data_3K36 # _entry.id 3K36 # _audit_conform.dict_name mmcif_pdbx.dic _audit_conform.dict_version 5.279 _audit_conform.dict_location http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic # loop_ _database_2.database_id _database_2.database_code PDB 3K36 RCSB RCSB055487 WWPDB D_1000055487 # loop_ _pdbx_database_related.db_name _pdbx_database_related.db_id _pdbx_database_related.details _pdbx_database_related.content_type PDB 3K37 . unspecified PDB 3K38 . unspecified PDB 3K39 . unspecified PDB 3K3A . unspecified # _pdbx_database_status.status_code REL _pdbx_database_status.entry_id 3K36 _pdbx_database_status.recvd_initial_deposition_date 2009-10-02 _pdbx_database_status.deposit_site RCSB _pdbx_database_status.process_site PDBJ _pdbx_database_status.status_code_sf REL _pdbx_database_status.status_code_mr ? _pdbx_database_status.SG_entry ? _pdbx_database_status.pdb_format_compatible Y _pdbx_database_status.status_code_cs ? # loop_ _audit_author.name _audit_author.pdbx_ordinal 'Oakley, A.J.' 1 'McKimm-Breschkin, J.L.' 2 # _citation.id primary _citation.title 'Structural and Functional Basis of Resistance to Neuraminidase Inhibitors of Influenza B Viruses.' _citation.journal_abbrev J.Med.Chem. _citation.journal_volume ? _citation.page_first ? _citation.page_last ? _citation.year 2010 _citation.journal_id_ASTM JMCMAR _citation.country US _citation.journal_id_ISSN 0022-2623 _citation.journal_id_CSD 0151 _citation.book_publisher ? _citation.pdbx_database_id_PubMed 20695427 _citation.pdbx_database_id_DOI 10.1021/jm100621s # loop_ _citation_author.citation_id _citation_author.name _citation_author.ordinal primary 'Oakley, A.J.' 1 primary 'Barrett, S.' 2 primary 'Peat, T.S.' 3 primary 'Newman, J.' 4 primary 'Streltsov, V.A.' 5 primary 'Waddington, L.' 6 primary 'Saito, T.' 7 primary 'Tashiro, M.' 8 primary 'McKimm-Breschkin, J.L.' 9 # _cell.entry_id 3K36 _cell.length_a 87.640 _cell.length_b 87.640 _cell.length_c 197.190 _cell.angle_alpha 90.00 _cell.angle_beta 90.00 _cell.angle_gamma 90.00 _cell.Z_PDB 16 _cell.pdbx_unique_axis ? _cell.length_a_esd ? _cell.length_b_esd ? _cell.length_c_esd ? _cell.angle_alpha_esd ? _cell.angle_beta_esd ? _cell.angle_gamma_esd ? # _symmetry.entry_id 3K36 _symmetry.space_group_name_H-M 'I 4' _symmetry.pdbx_full_space_group_name_H-M ? _symmetry.cell_setting ? _symmetry.Int_Tables_number 79 _symmetry.space_group_name_Hall ? # loop_ _entity.id _entity.type _entity.src_method _entity.pdbx_description _entity.formula_weight _entity.pdbx_number_of_molecules _entity.pdbx_ec _entity.pdbx_mutation _entity.pdbx_fragment _entity.details 1 polymer man Neuraminidase 43824.836 2 3.2.1.18 ? 'UNP residues 70-466' ? 2 non-polymer man N-ACETYL-D-GLUCOSAMINE 221.208 4 ? ? ? ? 3 non-polymer man BETA-D-MANNOSE 180.156 2 ? ? ? ? 4 non-polymer man ALPHA-D-MANNOSE 180.156 6 ? ? ? ? 5 non-polymer syn 'SULFATE ION' 96.063 2 ? ? ? ? 6 non-polymer syn 1,2-ETHANEDIOL 62.068 2 ? ? ? ? 7 non-polymer syn GLYCEROL 92.094 4 ? ? ? ? 8 non-polymer syn 'CALCIUM ION' 40.078 2 ? ? ? ? 9 water nat water 18.015 316 ? ? ? ? # _entity_poly.entity_id 1 _entity_poly.type 'polypeptide(L)' _entity_poly.nstd_linkage no _entity_poly.nstd_monomer no _entity_poly.pdbx_seq_one_letter_code ;GVTLLLPEPEWTYPRLSCPGSTFQKALLISPHRFGETKGNSAPLIIREPFIACGPKECKHFALTHYAAQPGGYYNGTRGD RNKLRHLISVKLGKIPTVENSIFHMAAWSGSACHDGKEWTYIGVDGPDNNALLKIKYGEAYTDTYHSYANNILRTQESAC NCIGGNCYLMITDGSASGISECRFLKIREGRIIKEIFPTGRVKHTEECTCGFASNKTIECACRDNSYTAKRPFVKLNVET DTAEIRLMCTETYLDTPRPDDGSITGPCESNGDKGSGGIKGGFVHQRMASKIGRWYSRTMSKTKRMGMGLYVKYDGDPWT DSDALALSGVMVSMEEPGWYSFGFEIKDKKCDVPCIGIEMVHDGGKETWHSAATAIYCLMGSGQLLWDTVTGVDMAL ; _entity_poly.pdbx_seq_one_letter_code_can ;GVTLLLPEPEWTYPRLSCPGSTFQKALLISPHRFGETKGNSAPLIIREPFIACGPKECKHFALTHYAAQPGGYYNGTRGD RNKLRHLISVKLGKIPTVENSIFHMAAWSGSACHDGKEWTYIGVDGPDNNALLKIKYGEAYTDTYHSYANNILRTQESAC NCIGGNCYLMITDGSASGISECRFLKIREGRIIKEIFPTGRVKHTEECTCGFASNKTIECACRDNSYTAKRPFVKLNVET DTAEIRLMCTETYLDTPRPDDGSITGPCESNGDKGSGGIKGGFVHQRMASKIGRWYSRTMSKTKRMGMGLYVKYDGDPWT DSDALALSGVMVSMEEPGWYSFGFEIKDKKCDVPCIGIEMVHDGGKETWHSAATAIYCLMGSGQLLWDTVTGVDMAL ; _entity_poly.pdbx_strand_id A,B _entity_poly.pdbx_target_identifier ? # loop_ _entity_poly_seq.entity_id _entity_poly_seq.num _entity_poly_seq.mon_id _entity_poly_seq.hetero 1 1 GLY n 1 2 VAL n 1 3 THR n 1 4 LEU n 1 5 LEU n 1 6 LEU n 1 7 PRO n 1 8 GLU n 1 9 PRO n 1 10 GLU n 1 11 TRP n 1 12 THR n 1 13 TYR n 1 14 PRO n 1 15 ARG n 1 16 LEU n 1 17 SER n 1 18 CYS n 1 19 PRO n 1 20 GLY n 1 21 SER n 1 22 THR n 1 23 PHE n 1 24 GLN n 1 25 LYS n 1 26 ALA n 1 27 LEU n 1 28 LEU n 1 29 ILE n 1 30 SER n 1 31 PRO n 1 32 HIS n 1 33 ARG n 1 34 PHE n 1 35 GLY n 1 36 GLU n 1 37 THR n 1 38 LYS n 1 39 GLY n 1 40 ASN n 1 41 SER n 1 42 ALA n 1 43 PRO n 1 44 LEU n 1 45 ILE n 1 46 ILE n 1 47 ARG n 1 48 GLU n 1 49 PRO n 1 50 PHE n 1 51 ILE n 1 52 ALA n 1 53 CYS n 1 54 GLY n 1 55 PRO n 1 56 LYS n 1 57 GLU n 1 58 CYS n 1 59 LYS n 1 60 HIS n 1 61 PHE n 1 62 ALA n 1 63 LEU n 1 64 THR n 1 65 HIS n 1 66 TYR n 1 67 ALA n 1 68 ALA n 1 69 GLN n 1 70 PRO n 1 71 GLY n 1 72 GLY n 1 73 TYR n 1 74 TYR n 1 75 ASN n 1 76 GLY n 1 77 THR n 1 78 ARG n 1 79 GLY n 1 80 ASP n 1 81 ARG n 1 82 ASN n 1 83 LYS n 1 84 LEU n 1 85 ARG n 1 86 HIS n 1 87 LEU n 1 88 ILE n 1 89 SER n 1 90 VAL n 1 91 LYS n 1 92 LEU n 1 93 GLY n 1 94 LYS n 1 95 ILE n 1 96 PRO n 1 97 THR n 1 98 VAL n 1 99 GLU n 1 100 ASN n 1 101 SER n 1 102 ILE n 1 103 PHE n 1 104 HIS n 1 105 MET n 1 106 ALA n 1 107 ALA n 1 108 TRP n 1 109 SER n 1 110 GLY n 1 111 SER n 1 112 ALA n 1 113 CYS n 1 114 HIS n 1 115 ASP n 1 116 GLY n 1 117 LYS n 1 118 GLU n 1 119 TRP n 1 120 THR n 1 121 TYR n 1 122 ILE n 1 123 GLY n 1 124 VAL n 1 125 ASP n 1 126 GLY n 1 127 PRO n 1 128 ASP n 1 129 ASN n 1 130 ASN n 1 131 ALA n 1 132 LEU n 1 133 LEU n 1 134 LYS n 1 135 ILE n 1 136 LYS n 1 137 TYR n 1 138 GLY n 1 139 GLU n 1 140 ALA n 1 141 TYR n 1 142 THR n 1 143 ASP n 1 144 THR n 1 145 TYR n 1 146 HIS n 1 147 SER n 1 148 TYR n 1 149 ALA n 1 150 ASN n 1 151 ASN n 1 152 ILE n 1 153 LEU n 1 154 ARG n 1 155 THR n 1 156 GLN n 1 157 GLU n 1 158 SER n 1 159 ALA n 1 160 CYS n 1 161 ASN n 1 162 CYS n 1 163 ILE n 1 164 GLY n 1 165 GLY n 1 166 ASN n 1 167 CYS n 1 168 TYR n 1 169 LEU n 1 170 MET n 1 171 ILE n 1 172 THR n 1 173 ASP n 1 174 GLY n 1 175 SER n 1 176 ALA n 1 177 SER n 1 178 GLY n 1 179 ILE n 1 180 SER n 1 181 GLU n 1 182 CYS n 1 183 ARG n 1 184 PHE n 1 185 LEU n 1 186 LYS n 1 187 ILE n 1 188 ARG n 1 189 GLU n 1 190 GLY n 1 191 ARG n 1 192 ILE n 1 193 ILE n 1 194 LYS n 1 195 GLU n 1 196 ILE n 1 197 PHE n 1 198 PRO n 1 199 THR n 1 200 GLY n 1 201 ARG n 1 202 VAL n 1 203 LYS n 1 204 HIS n 1 205 THR n 1 206 GLU n 1 207 GLU n 1 208 CYS n 1 209 THR n 1 210 CYS n 1 211 GLY n 1 212 PHE n 1 213 ALA n 1 214 SER n 1 215 ASN n 1 216 LYS n 1 217 THR n 1 218 ILE n 1 219 GLU n 1 220 CYS n 1 221 ALA n 1 222 CYS n 1 223 ARG n 1 224 ASP n 1 225 ASN n 1 226 SER n 1 227 TYR n 1 228 THR n 1 229 ALA n 1 230 LYS n 1 231 ARG n 1 232 PRO n 1 233 PHE n 1 234 VAL n 1 235 LYS n 1 236 LEU n 1 237 ASN n 1 238 VAL n 1 239 GLU n 1 240 THR n 1 241 ASP n 1 242 THR n 1 243 ALA n 1 244 GLU n 1 245 ILE n 1 246 ARG n 1 247 LEU n 1 248 MET n 1 249 CYS n 1 250 THR n 1 251 GLU n 1 252 THR n 1 253 TYR n 1 254 LEU n 1 255 ASP n 1 256 THR n 1 257 PRO n 1 258 ARG n 1 259 PRO n 1 260 ASP n 1 261 ASP n 1 262 GLY n 1 263 SER n 1 264 ILE n 1 265 THR n 1 266 GLY n 1 267 PRO n 1 268 CYS n 1 269 GLU n 1 270 SER n 1 271 ASN n 1 272 GLY n 1 273 ASP n 1 274 LYS n 1 275 GLY n 1 276 SER n 1 277 GLY n 1 278 GLY n 1 279 ILE n 1 280 LYS n 1 281 GLY n 1 282 GLY n 1 283 PHE n 1 284 VAL n 1 285 HIS n 1 286 GLN n 1 287 ARG n 1 288 MET n 1 289 ALA n 1 290 SER n 1 291 LYS n 1 292 ILE n 1 293 GLY n 1 294 ARG n 1 295 TRP n 1 296 TYR n 1 297 SER n 1 298 ARG n 1 299 THR n 1 300 MET n 1 301 SER n 1 302 LYS n 1 303 THR n 1 304 LYS n 1 305 ARG n 1 306 MET n 1 307 GLY n 1 308 MET n 1 309 GLY n 1 310 LEU n 1 311 TYR n 1 312 VAL n 1 313 LYS n 1 314 TYR n 1 315 ASP n 1 316 GLY n 1 317 ASP n 1 318 PRO n 1 319 TRP n 1 320 THR n 1 321 ASP n 1 322 SER n 1 323 ASP n 1 324 ALA n 1 325 LEU n 1 326 ALA n 1 327 LEU n 1 328 SER n 1 329 GLY n 1 330 VAL n 1 331 MET n 1 332 VAL n 1 333 SER n 1 334 MET n 1 335 GLU n 1 336 GLU n 1 337 PRO n 1 338 GLY n 1 339 TRP n 1 340 TYR n 1 341 SER n 1 342 PHE n 1 343 GLY n 1 344 PHE n 1 345 GLU n 1 346 ILE n 1 347 LYS n 1 348 ASP n 1 349 LYS n 1 350 LYS n 1 351 CYS n 1 352 ASP n 1 353 VAL n 1 354 PRO n 1 355 CYS n 1 356 ILE n 1 357 GLY n 1 358 ILE n 1 359 GLU n 1 360 MET n 1 361 VAL n 1 362 HIS n 1 363 ASP n 1 364 GLY n 1 365 GLY n 1 366 LYS n 1 367 GLU n 1 368 THR n 1 369 TRP n 1 370 HIS n 1 371 SER n 1 372 ALA n 1 373 ALA n 1 374 THR n 1 375 ALA n 1 376 ILE n 1 377 TYR n 1 378 CYS n 1 379 LEU n 1 380 MET n 1 381 GLY n 1 382 SER n 1 383 GLY n 1 384 GLN n 1 385 LEU n 1 386 LEU n 1 387 TRP n 1 388 ASP n 1 389 THR n 1 390 VAL n 1 391 THR n 1 392 GLY n 1 393 VAL n 1 394 ASP n 1 395 MET n 1 396 ALA n 1 397 LEU n # _entity_src_gen.entity_id 1 _entity_src_gen.pdbx_src_id 1 _entity_src_gen.pdbx_alt_source_flag sample _entity_src_gen.pdbx_seq_type ? _entity_src_gen.pdbx_beg_seq_num ? _entity_src_gen.pdbx_end_seq_num ? _entity_src_gen.gene_src_common_name Viruses _entity_src_gen.gene_src_genus ? _entity_src_gen.pdbx_gene_src_gene ? _entity_src_gen.gene_src_species ? _entity_src_gen.gene_src_strain B/Perth/211/2001 _entity_src_gen.gene_src_tissue ? _entity_src_gen.gene_src_tissue_fraction ? _entity_src_gen.gene_src_details ? _entity_src_gen.pdbx_gene_src_fragment ? _entity_src_gen.pdbx_gene_src_scientific_name 'Influenza B virus' _entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 343983 _entity_src_gen.pdbx_gene_src_variant ? _entity_src_gen.pdbx_gene_src_cell_line ? _entity_src_gen.pdbx_gene_src_atcc ? _entity_src_gen.pdbx_gene_src_organ ? _entity_src_gen.pdbx_gene_src_organelle ? _entity_src_gen.pdbx_gene_src_cell ? _entity_src_gen.pdbx_gene_src_cellular_location ? _entity_src_gen.host_org_common_name 'Fall armyworm' _entity_src_gen.pdbx_host_org_scientific_name 'Spodoptera frugiperda' _entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 7108 _entity_src_gen.host_org_genus ? _entity_src_gen.pdbx_host_org_gene ? _entity_src_gen.pdbx_host_org_organ ? _entity_src_gen.host_org_species ? _entity_src_gen.pdbx_host_org_tissue ? _entity_src_gen.pdbx_host_org_tissue_fraction ? _entity_src_gen.pdbx_host_org_strain ? _entity_src_gen.pdbx_host_org_variant ? _entity_src_gen.pdbx_host_org_cell_line Sf21 _entity_src_gen.pdbx_host_org_atcc ? _entity_src_gen.pdbx_host_org_culture_collection ? _entity_src_gen.pdbx_host_org_cell ? _entity_src_gen.pdbx_host_org_organelle ? _entity_src_gen.pdbx_host_org_cellular_location ? _entity_src_gen.pdbx_host_org_vector_type Baculovirus _entity_src_gen.pdbx_host_org_vector pFastBac _entity_src_gen.host_org_details ? _entity_src_gen.expression_system_id ? _entity_src_gen.plasmid_name ? _entity_src_gen.plasmid_details ? _entity_src_gen.pdbx_description ? # _struct_ref.id 1 _struct_ref.db_name UNP _struct_ref.db_code Q3S340_9INFB _struct_ref.pdbx_db_accession Q3S340 _struct_ref.entity_id 1 _struct_ref.pdbx_seq_one_letter_code ;GVTLLLPEPEWTYPRLSCPGSTFQKALLISPHRFGETKGNSAPLIIREPFIACGPKECKHFALTHYAAQPGGYYNGTRGD RNKLRHLISVKLGKIPTVENSIFHMAAWSGSACHDGKEWTYIGVDGPDNNALLKIKYGEAYTDTYHSYANNILRTQESAC NCIGGNCYLMITDGSASGISECRFLKIREGRIIKEIFPTGRVKHTEECTCGFASNKTIECACRDNSYTAKRPFVKLNVET DTAEIRLMCTETYLDTPRPDDGSITGPCESNGDKGSGGIKGGFVHQRMASKIGRWYSRTMSKTKRMGMGLYVKYDGDPWT DSDALALSGVMVSMEEPGWYSFGFEIKDKKCDVPCIGIEMVHDGGKETWHSAATAIYCLMGSGQLLWDTVTGVDMAL ; _struct_ref.pdbx_align_begin 70 _struct_ref.pdbx_db_isoform ? # loop_ _struct_ref_seq.align_id _struct_ref_seq.ref_id _struct_ref_seq.pdbx_PDB_id_code _struct_ref_seq.pdbx_strand_id _struct_ref_seq.seq_align_beg _struct_ref_seq.pdbx_seq_align_beg_ins_code _struct_ref_seq.seq_align_end _struct_ref_seq.pdbx_seq_align_end_ins_code _struct_ref_seq.pdbx_db_accession _struct_ref_seq.db_align_beg _struct_ref_seq.pdbx_db_align_beg_ins_code _struct_ref_seq.db_align_end _struct_ref_seq.pdbx_db_align_end_ins_code _struct_ref_seq.pdbx_auth_seq_align_beg _struct_ref_seq.pdbx_auth_seq_align_end 1 1 3K36 A 1 ? 397 ? Q3S340 70 ? 466 ? 70 466 2 1 3K36 B 1 ? 397 ? Q3S340 70 ? 466 ? 70 466 # loop_ _chem_comp.id _chem_comp.type _chem_comp.mon_nstd_flag _chem_comp.name _chem_comp.pdbx_synonyms _chem_comp.formula _chem_comp.formula_weight ALA 'L-peptide linking' y ALANINE ? 'C3 H7 N O2' 89.093 ARG 'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1' 175.209 ASN 'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3' 132.118 ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4' 133.103 BMA D-saccharide . BETA-D-MANNOSE ? 'C6 H12 O6' 180.156 CA non-polymer . 'CALCIUM ION' ? 'Ca 2' 40.078 CYS 'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S' 121.158 EDO non-polymer . 1,2-ETHANEDIOL 'ETHYLENE GLYCOL' 'C2 H6 O2' 62.068 GLN 'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3' 146.144 GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4' 147.129 GLY 'peptide linking' y GLYCINE ? 'C2 H5 N O2' 75.067 GOL non-polymer . GLYCEROL 'GLYCERIN; PROPANE-1,2,3-TRIOL' 'C3 H8 O3' 92.094 HIS 'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1' 156.162 HOH non-polymer . WATER ? 'H2 O' 18.015 ILE 'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2' 131.173 LEU 'L-peptide linking' y LEUCINE ? 'C6 H13 N O2' 131.173 LYS 'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1' 147.195 MAN D-saccharide . ALPHA-D-MANNOSE ? 'C6 H12 O6' 180.156 MET 'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S' 149.211 NAG D-saccharide . N-ACETYL-D-GLUCOSAMINE ? 'C8 H15 N O6' 221.208 PHE 'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2' 165.189 PRO 'L-peptide linking' y PROLINE ? 'C5 H9 N O2' 115.130 SER 'L-peptide linking' y SERINE ? 'C3 H7 N O3' 105.093 SO4 non-polymer . 'SULFATE ION' ? 'O4 S -2' 96.063 THR 'L-peptide linking' y THREONINE ? 'C4 H9 N O3' 119.119 TRP 'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2' 204.225 TYR 'L-peptide linking' y TYROSINE ? 'C9 H11 N O3' 181.189 VAL 'L-peptide linking' y VALINE ? 'C5 H11 N O2' 117.146 # _exptl.entry_id 3K36 _exptl.method 'X-RAY DIFFRACTION' _exptl.crystals_number 1 # _exptl_crystal.id 1 _exptl_crystal.density_meas ? _exptl_crystal.density_Matthews 2.16 _exptl_crystal.density_percent_sol 43.05 _exptl_crystal.description ? _exptl_crystal.F_000 ? _exptl_crystal.preparation ? # _exptl_crystal_grow.crystal_id 1 _exptl_crystal_grow.method 'VAPOR DIFFUSION, SITTING DROP' _exptl_crystal_grow.temp 281.15 _exptl_crystal_grow.temp_details ? _exptl_crystal_grow.pH 6.5 _exptl_crystal_grow.pdbx_details '0.2M Na2SO4, 20% w/v PEG3350, 0.1M bis-Tris propane, pH6.5, VAPOR DIFFUSION, SITTING DROP, temperature 281.15K' _exptl_crystal_grow.pdbx_pH_range . # _diffrn.id 1 _diffrn.ambient_temp 100 _diffrn.ambient_temp_details ? _diffrn.crystal_id 1 # _diffrn_detector.diffrn_id 1 _diffrn_detector.detector CCD _diffrn_detector.type 'MAR CCD 165 mm' _diffrn_detector.pdbx_collection_date 2007-11-28 _diffrn_detector.details 'BEAMLINE OPTICS' # _diffrn_radiation.diffrn_id 1 _diffrn_radiation.wavelength_id 1 _diffrn_radiation.pdbx_monochromatic_or_laue_m_l M _diffrn_radiation.monochromator 'BEAMLINE OPTICS' _diffrn_radiation.pdbx_diffrn_protocol 'SINGLE WAVELENGTH' _diffrn_radiation.pdbx_scattering_type x-ray # _diffrn_radiation_wavelength.id 1 _diffrn_radiation_wavelength.wavelength 0.95361 _diffrn_radiation_wavelength.wt 1.0 # _diffrn_source.diffrn_id 1 _diffrn_source.source SYNCHROTRON _diffrn_source.type 'AUSTRALIAN SYNCHROTRON BEAMLINE MX1' _diffrn_source.pdbx_synchrotron_site 'Australian Synchrotron' _diffrn_source.pdbx_synchrotron_beamline MX1 _diffrn_source.pdbx_wavelength ? _diffrn_source.pdbx_wavelength_list 0.95361 # _reflns.entry_id 3K36 _reflns.observed_criterion_sigma_I -1 _reflns.observed_criterion_sigma_F -1 _reflns.d_resolution_low ? _reflns.d_resolution_high 2.2 _reflns.number_obs 34306 _reflns.number_all 34306 _reflns.percent_possible_obs 91.5 _reflns.pdbx_Rmerge_I_obs 0.122 _reflns.pdbx_Rsym_value ? _reflns.pdbx_netI_over_sigmaI 11.6 _reflns.B_iso_Wilson_estimate 20.979 _reflns.pdbx_redundancy 4.5 _reflns.R_free_details ? _reflns.limit_h_max ? _reflns.limit_h_min ? _reflns.limit_k_max ? _reflns.limit_k_min ? _reflns.limit_l_max ? _reflns.limit_l_min ? _reflns.observed_criterion_F_max ? _reflns.observed_criterion_F_min ? _reflns.pdbx_chi_squared ? _reflns.pdbx_scaling_rejects ? _reflns.pdbx_diffrn_id 1 _reflns.pdbx_ordinal 1 # _reflns_shell.d_res_high 2.20 _reflns_shell.d_res_low 2.32 _reflns_shell.percent_possible_all 77.6 _reflns_shell.Rmerge_I_obs 0.438 _reflns_shell.pdbx_Rsym_value ? _reflns_shell.meanI_over_sigI_obs 2.7 _reflns_shell.pdbx_redundancy 2.9 _reflns_shell.percent_possible_obs ? _reflns_shell.number_unique_all 12265 _reflns_shell.number_measured_all ? _reflns_shell.number_measured_obs ? _reflns_shell.number_unique_obs ? _reflns_shell.pdbx_chi_squared ? _reflns_shell.pdbx_diffrn_id ? _reflns_shell.pdbx_ordinal 1 # _refine.entry_id 3K36 _refine.ls_number_reflns_obs 32580 _refine.ls_number_reflns_all 32580 _refine.pdbx_ls_sigma_I ? _refine.pdbx_ls_sigma_F ? _refine.pdbx_data_cutoff_high_absF ? _refine.pdbx_data_cutoff_low_absF ? _refine.pdbx_data_cutoff_high_rms_absF ? _refine.ls_d_res_low 98.53 _refine.ls_d_res_high 2.20 _refine.ls_percent_reflns_obs 91.32 _refine.ls_R_factor_obs 0.18511 _refine.ls_R_factor_all ? _refine.ls_R_factor_R_work 0.18230 _refine.ls_R_factor_R_free 0.23929 _refine.ls_R_factor_R_free_error ? _refine.ls_R_factor_R_free_error_details ? _refine.ls_percent_reflns_R_free 5.0 _refine.ls_number_reflns_R_free 1726 _refine.ls_number_parameters ? _refine.ls_number_restraints ? _refine.occupancy_min ? _refine.occupancy_max ? _refine.correlation_coeff_Fo_to_Fc 0.939 _refine.correlation_coeff_Fo_to_Fc_free 0.892 _refine.B_iso_mean 17.369 _refine.aniso_B[1][1] -1.54 _refine.aniso_B[2][2] -1.54 _refine.aniso_B[3][3] 3.09 _refine.aniso_B[1][2] 0.00 _refine.aniso_B[1][3] 0.00 _refine.aniso_B[2][3] 0.00 _refine.solvent_model_details 'BABINET MODEL WITH MASK' _refine.solvent_model_param_ksol ? _refine.solvent_model_param_bsol ? _refine.pdbx_solvent_vdw_probe_radii 1.20 _refine.pdbx_solvent_ion_probe_radii 0.80 _refine.pdbx_solvent_shrinkage_radii 0.80 _refine.pdbx_ls_cross_valid_method THROUGHOUT _refine.details 'HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS' _refine.pdbx_starting_model 'PDB ENTRY 7NN9' _refine.pdbx_method_to_determine_struct 'MOLECULAR REPLACEMENT' _refine.pdbx_isotropic_thermal_model ? _refine.pdbx_stereochemistry_target_values 'MAXIMUM LIKELIHOOD' _refine.pdbx_stereochem_target_val_spec_case ? _refine.pdbx_R_Free_selection_details RANDOM _refine.pdbx_overall_ESU_R 0.431 _refine.pdbx_overall_ESU_R_Free 0.248 _refine.overall_SU_ML 0.157 _refine.overall_SU_B 6.133 _refine.ls_redundancy_reflns_obs ? _refine.B_iso_min ? _refine.B_iso_max ? _refine.overall_SU_R_Cruickshank_DPI ? _refine.overall_SU_R_free ? _refine.ls_wR_factor_R_free ? _refine.ls_wR_factor_R_work ? _refine.overall_FOM_free_R_set ? _refine.overall_FOM_work_R_set ? _refine.pdbx_refine_id 'X-RAY DIFFRACTION' _refine.pdbx_overall_phase_error ? _refine.pdbx_diffrn_id 1 _refine.pdbx_TLS_residual_ADP_flag ? _refine.pdbx_overall_SU_R_free_Cruickshank_DPI ? _refine.pdbx_overall_SU_R_Blow_DPI ? _refine.pdbx_overall_SU_R_free_Blow_DPI ? # _refine_hist.pdbx_refine_id 'X-RAY DIFFRACTION' _refine_hist.cycle_id LAST _refine_hist.pdbx_number_atoms_protein 6012 _refine_hist.pdbx_number_atoms_nucleic_acid 0 _refine_hist.pdbx_number_atoms_ligand 188 _refine_hist.number_atoms_solvent 316 _refine_hist.number_atoms_total 6516 _refine_hist.d_res_high 2.20 _refine_hist.d_res_low 98.53 # loop_ _refine_ls_restr.type _refine_ls_restr.dev_ideal _refine_ls_restr.dev_ideal_target _refine_ls_restr.weight _refine_ls_restr.number _refine_ls_restr.pdbx_refine_id _refine_ls_restr.pdbx_restraint_function r_bond_refined_d 0.014 0.021 ? 6439 'X-RAY DIFFRACTION' ? r_bond_other_d 0.002 0.020 ? 4441 'X-RAY DIFFRACTION' ? r_angle_refined_deg 1.560 1.982 ? 8740 'X-RAY DIFFRACTION' ? r_angle_other_deg 0.921 3.000 ? 10776 'X-RAY DIFFRACTION' ? r_dihedral_angle_1_deg 7.942 5.000 ? 802 'X-RAY DIFFRACTION' ? r_dihedral_angle_2_deg 33.073 23.509 ? 265 'X-RAY DIFFRACTION' ? r_dihedral_angle_3_deg 18.274 15.000 ? 1065 'X-RAY DIFFRACTION' ? r_dihedral_angle_4_deg 17.163 15.000 ? 38 'X-RAY DIFFRACTION' ? r_chiral_restr 0.091 0.200 ? 952 'X-RAY DIFFRACTION' ? r_gen_planes_refined 0.006 0.021 ? 7041 'X-RAY DIFFRACTION' ? r_gen_planes_other 0.001 0.020 ? 1292 'X-RAY DIFFRACTION' ? r_nbd_refined ? ? ? ? 'X-RAY DIFFRACTION' ? r_nbd_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_nbtor_refined ? ? ? ? 'X-RAY DIFFRACTION' ? r_nbtor_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_xyhbond_nbd_refined ? ? ? ? 'X-RAY DIFFRACTION' ? r_xyhbond_nbd_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_metal_ion_refined ? ? ? ? 'X-RAY DIFFRACTION' ? r_metal_ion_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_symmetry_vdw_refined ? ? ? ? 'X-RAY DIFFRACTION' ? r_symmetry_vdw_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_symmetry_hbond_refined ? ? ? ? 'X-RAY DIFFRACTION' ? r_symmetry_hbond_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_symmetry_metal_ion_refined ? ? ? ? 'X-RAY DIFFRACTION' ? r_symmetry_metal_ion_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_mcbond_it 0.584 1.500 ? 3881 'X-RAY DIFFRACTION' ? r_mcbond_other 0.137 1.500 ? 1621 'X-RAY DIFFRACTION' ? r_mcangle_it 1.053 2.000 ? 6245 'X-RAY DIFFRACTION' ? r_scbond_it 1.707 3.000 ? 2558 'X-RAY DIFFRACTION' ? r_scangle_it 2.581 4.500 ? 2482 'X-RAY DIFFRACTION' ? r_rigid_bond_restr ? ? ? ? 'X-RAY DIFFRACTION' ? r_sphericity_free ? ? ? ? 'X-RAY DIFFRACTION' ? r_sphericity_bonded ? ? ? ? 'X-RAY DIFFRACTION' ? # loop_ _refine_ls_restr_ncs.dom_id _refine_ls_restr_ncs.pdbx_auth_asym_id _refine_ls_restr_ncs.pdbx_number _refine_ls_restr_ncs.rms_dev_position _refine_ls_restr_ncs.weight_position _refine_ls_restr_ncs.pdbx_type _refine_ls_restr_ncs.pdbx_ens_id _refine_ls_restr_ncs.pdbx_ordinal _refine_ls_restr_ncs.pdbx_refine_id _refine_ls_restr_ncs.ncs_model_details _refine_ls_restr_ncs.rms_dev_B_iso _refine_ls_restr_ncs.weight_B_iso 1 A 2272 0.08 0.50 'medium positional' 1 1 'X-RAY DIFFRACTION' ? ? ? 1 A 2861 0.17 5.00 'loose positional' 1 2 'X-RAY DIFFRACTION' ? ? ? 1 A 2272 0.72 2.00 'medium thermal' 1 3 'X-RAY DIFFRACTION' ? ? ? 1 A 2861 1.18 10.00 'loose thermal' 1 4 'X-RAY DIFFRACTION' ? ? ? # _refine_ls_shell.pdbx_total_number_of_bins_used 20 _refine_ls_shell.d_res_high 2.200 _refine_ls_shell.d_res_low 2.257 _refine_ls_shell.number_reflns_R_work 2000 _refine_ls_shell.R_factor_R_work 0.227 _refine_ls_shell.percent_reflns_obs 76.19 _refine_ls_shell.R_factor_R_free 0.319 _refine_ls_shell.R_factor_R_free_error ? _refine_ls_shell.percent_reflns_R_free ? _refine_ls_shell.number_reflns_R_free 122 _refine_ls_shell.number_reflns_all ? _refine_ls_shell.R_factor_all ? _refine_ls_shell.number_reflns_obs ? _refine_ls_shell.redundancy_reflns_obs ? _refine_ls_shell.pdbx_refine_id 'X-RAY DIFFRACTION' # loop_ _struct_ncs_dom.id _struct_ncs_dom.details _struct_ncs_dom.pdbx_ens_id 1 A 1 2 B 1 # loop_ _struct_ncs_dom_lim.dom_id _struct_ncs_dom_lim.beg_auth_asym_id _struct_ncs_dom_lim.beg_auth_seq_id _struct_ncs_dom_lim.end_auth_asym_id _struct_ncs_dom_lim.end_auth_seq_id _struct_ncs_dom_lim.pdbx_component_id _struct_ncs_dom_lim.pdbx_refine_code _struct_ncs_dom_lim.beg_label_asym_id _struct_ncs_dom_lim.beg_label_comp_id _struct_ncs_dom_lim.beg_label_seq_id _struct_ncs_dom_lim.beg_label_alt_id _struct_ncs_dom_lim.end_label_asym_id _struct_ncs_dom_lim.end_label_comp_id _struct_ncs_dom_lim.end_label_seq_id _struct_ncs_dom_lim.end_label_alt_id _struct_ncs_dom_lim.pdbx_ens_id _struct_ncs_dom_lim.selection_details 1 A 78 A 466 1 5 ? ? ? ? ? ? ? ? 1 ? 2 B 78 B 466 2 5 ? ? ? ? ? ? ? ? 1 ? # _struct_ncs_ens.id 1 _struct_ncs_ens.details ? # _struct.entry_id 3K36 _struct.title 'Crystal Structure of B/Perth Neuraminidase' _struct.pdbx_descriptor 'Neuraminidase (E.C.3.2.1.18)' _struct.pdbx_model_details ? _struct.pdbx_CASP_flag ? _struct.pdbx_model_type_details ? # _struct_keywords.entry_id 3K36 _struct_keywords.pdbx_keywords HYDROLASE _struct_keywords.text 'INFLUENZA, NEURAMINIDASE, MUTATION, RESISTANCE, HYDROLASE, Cell membrane, Glycosidase, Membrane, Transmembrane, Virion' # loop_ _struct_asym.id _struct_asym.pdbx_blank_PDB_chainid_flag _struct_asym.pdbx_modified _struct_asym.entity_id _struct_asym.details A N N 1 ? B N N 1 ? C N N 2 ? D N N 2 ? E N N 3 ? F N N 4 ? G N N 4 ? H N N 4 ? I N N 5 ? J N N 6 ? K N N 7 ? L N N 8 ? M N N 2 ? N N N 2 ? O N N 3 ? P N N 4 ? Q N N 4 ? R N N 4 ? S N N 5 ? T N N 6 ? U N N 7 ? V N N 7 ? W N N 7 ? X N N 8 ? Y N N 9 ? Z N N 9 ? # _struct_biol.id 1 _struct_biol.details ? # loop_ _struct_conf.conf_type_id _struct_conf.id _struct_conf.pdbx_PDB_helix_id _struct_conf.beg_label_comp_id _struct_conf.beg_label_asym_id _struct_conf.beg_label_seq_id _struct_conf.pdbx_beg_PDB_ins_code _struct_conf.end_label_comp_id _struct_conf.end_label_asym_id _struct_conf.end_label_seq_id _struct_conf.pdbx_end_PDB_ins_code _struct_conf.beg_auth_comp_id _struct_conf.beg_auth_asym_id _struct_conf.beg_auth_seq_id _struct_conf.end_auth_comp_id _struct_conf.end_auth_asym_id _struct_conf.end_auth_seq_id _struct_conf.pdbx_PDB_helix_class _struct_conf.details _struct_conf.pdbx_PDB_helix_length HELX_P HELX_P1 1 SER A 30 ? GLY A 35 ? SER A 99 GLY A 104 5 ? 6 HELX_P HELX_P2 2 SER B 30 ? GLY B 35 ? SER B 99 GLY B 104 5 ? 6 HELX_P HELX_P3 3 PRO B 127 ? ASN B 130 ? PRO B 196 ASN B 199 5 ? 4 # _struct_conf_type.id HELX_P _struct_conf_type.criteria ? _struct_conf_type.reference ? # loop_ _struct_conn.id _struct_conn.conn_type_id _struct_conn.pdbx_leaving_atom_flag _struct_conn.pdbx_PDB_id _struct_conn.ptnr1_label_asym_id _struct_conn.ptnr1_label_comp_id _struct_conn.ptnr1_label_seq_id _struct_conn.ptnr1_label_atom_id _struct_conn.pdbx_ptnr1_label_alt_id _struct_conn.pdbx_ptnr1_PDB_ins_code _struct_conn.pdbx_ptnr1_standard_comp_id _struct_conn.ptnr1_symmetry _struct_conn.ptnr2_label_asym_id _struct_conn.ptnr2_label_comp_id _struct_conn.ptnr2_label_seq_id _struct_conn.ptnr2_label_atom_id _struct_conn.pdbx_ptnr2_label_alt_id _struct_conn.pdbx_ptnr2_PDB_ins_code _struct_conn.ptnr1_auth_asym_id _struct_conn.ptnr1_auth_comp_id _struct_conn.ptnr1_auth_seq_id _struct_conn.ptnr2_auth_asym_id _struct_conn.ptnr2_auth_comp_id _struct_conn.ptnr2_auth_seq_id _struct_conn.ptnr2_symmetry _struct_conn.pdbx_ptnr3_label_atom_id _struct_conn.pdbx_ptnr3_label_seq_id _struct_conn.pdbx_ptnr3_label_comp_id _struct_conn.pdbx_ptnr3_label_asym_id _struct_conn.pdbx_ptnr3_label_alt_id _struct_conn.pdbx_ptnr3_PDB_ins_code _struct_conn.details _struct_conn.pdbx_dist_value _struct_conn.pdbx_value_order disulf1 disulf ? ? A CYS 18 SG ? ? ? 1_555 A CYS 351 SG ? ? A CYS 87 A CYS 420 1_555 ? ? ? ? ? ? ? 2.072 ? disulf2 disulf ? ? A CYS 53 SG ? ? ? 1_555 A CYS 58 SG ? ? A CYS 122 A CYS 127 1_555 ? ? ? ? ? ? ? 2.060 ? disulf3 disulf ? ? A CYS 113 SG ? ? ? 1_555 A CYS 160 SG ? ? A CYS 182 A CYS 229 1_555 ? ? ? ? ? ? ? 2.061 ? disulf4 disulf ? ? A CYS 162 SG ? ? ? 1_555 A CYS 167 SG ? ? A CYS 231 A CYS 236 1_555 ? ? ? ? ? ? ? 2.030 ? disulf5 disulf ? ? A CYS 208 SG ? ? ? 1_555 A CYS 222 SG ? ? A CYS 277 A CYS 291 1_555 ? ? ? ? ? ? ? 2.095 ? disulf6 disulf ? ? A CYS 210 SG ? ? ? 1_555 A CYS 220 SG ? ? A CYS 279 A CYS 289 1_555 ? ? ? ? ? ? ? 2.059 ? disulf7 disulf ? ? A CYS 249 SG ? ? ? 1_555 A CYS 268 SG ? ? A CYS 318 A CYS 337 1_555 ? ? ? ? ? ? ? 2.064 ? disulf8 disulf ? ? A CYS 355 SG ? ? ? 1_555 A CYS 378 SG ? ? A CYS 424 A CYS 447 1_555 ? ? ? ? ? ? ? 2.053 ? disulf9 disulf ? ? B CYS 18 SG ? ? ? 1_555 B CYS 351 SG ? ? B CYS 87 B CYS 420 1_555 ? ? ? ? ? ? ? 2.093 ? disulf10 disulf ? ? B CYS 53 SG ? ? ? 1_555 B CYS 58 SG ? ? B CYS 122 B CYS 127 1_555 ? ? ? ? ? ? ? 2.068 ? disulf11 disulf ? ? B CYS 113 SG ? ? ? 1_555 B CYS 160 SG ? ? B CYS 182 B CYS 229 1_555 ? ? ? ? ? ? ? 2.063 ? disulf12 disulf ? ? B CYS 162 SG ? ? ? 1_555 B CYS 167 SG ? ? B CYS 231 B CYS 236 1_555 ? ? ? ? ? ? ? 2.022 ? disulf13 disulf ? ? B CYS 208 SG ? ? ? 1_555 B CYS 222 SG ? ? B CYS 277 B CYS 291 1_555 ? ? ? ? ? ? ? 2.086 ? disulf14 disulf ? ? B CYS 210 SG ? ? ? 1_555 B CYS 220 SG ? ? B CYS 279 B CYS 289 1_555 ? ? ? ? ? ? ? 2.074 ? disulf15 disulf ? ? B CYS 249 SG ? ? ? 1_555 B CYS 268 SG ? ? B CYS 318 B CYS 337 1_555 ? ? ? ? ? ? ? 2.051 ? disulf16 disulf ? ? B CYS 355 SG ? ? ? 1_555 B CYS 378 SG ? ? B CYS 424 B CYS 447 1_555 ? ? ? ? ? ? ? 2.091 ? covale1 covale ? ? O BMA . O6 ? ? ? 1_555 P MAN . C1 ? ? B BMA 3 B MAN 4 1_555 ? ? ? ? ? ? ? 1.435 ? covale2 covale ? ? P MAN . O3 ? ? ? 1_555 R MAN . C1 ? ? B MAN 4 B MAN 6 1_555 ? ? ? ? ? ? ? 1.437 ? covale3 covale ? ? C NAG . O4 ? ? ? 1_555 D NAG . C1 ? ? A NAG 1 A NAG 2 1_555 ? ? ? ? ? ? ? 1.438 ? covale4 covale ? ? M NAG . O4 ? ? ? 1_555 N NAG . C1 ? ? B NAG 1 B NAG 2 1_555 ? ? ? ? ? ? ? 1.441 ? covale5 covale ? ? N NAG . O4 ? ? ? 1_555 O BMA . C1 ? ? B NAG 2 B BMA 3 1_555 ? ? ? ? ? ? ? 1.441 ? covale6 covale ? ? A ASN 215 ND2 ? ? ? 1_555 C NAG . C1 ? ? A ASN 284 A NAG 1 1_555 ? ? ? ? ? ? ? 1.441 ? covale7 covale ? ? F MAN . O3 ? ? ? 1_555 H MAN . C1 ? ? A MAN 4 A MAN 6 1_555 ? ? ? ? ? ? ? 1.442 ? covale8 covale ? ? B ASN 215 ND2 ? ? ? 1_555 M NAG . C1 ? ? B ASN 284 B NAG 1 1_555 ? ? ? ? ? ? ? 1.442 ? covale9 covale ? ? D NAG . O4 ? ? ? 1_555 E BMA . C1 ? ? A NAG 2 A BMA 3 1_555 ? ? ? ? ? ? ? 1.443 ? covale10 covale ? ? E BMA . O6 ? ? ? 1_555 F MAN . C1 ? ? A BMA 3 A MAN 4 1_555 ? ? ? ? ? ? ? 1.444 ? covale11 covale ? ? P MAN . O6 ? ? ? 1_555 Q MAN . C1 ? ? B MAN 4 B MAN 5 1_555 ? ? ? ? ? ? ? 1.446 ? covale12 covale ? ? F MAN . O6 ? ? ? 1_555 G MAN . C1 ? ? A MAN 4 A MAN 5 1_555 ? ? ? ? ? ? ? 1.463 ? metalc1 metalc ? ? B ASP 224 O ? ? ? 1_555 X CA . CA ? ? B ASP 293 B CA 472 1_555 ? ? ? ? ? ? ? 2.226 ? metalc2 metalc ? ? A GLY 277 O ? ? ? 1_555 L CA . CA ? ? A GLY 346 A CA 470 1_555 ? ? ? ? ? ? ? 2.227 ? metalc3 metalc ? ? A ASP 224 O ? ? ? 1_555 L CA . CA ? ? A ASP 293 A CA 470 1_555 ? ? ? ? ? ? ? 2.338 ? metalc4 metalc ? ? B GLY 277 O ? ? ? 1_555 X CA . CA ? ? B GLY 346 B CA 472 1_555 ? ? ? ? ? ? ? 2.354 ? metalc5 metalc ? ? B GLY 275 O ? ? ? 1_555 X CA . CA ? ? B GLY 344 B CA 472 1_555 ? ? ? ? ? ? ? 2.492 ? metalc6 metalc ? ? A GLY 275 O ? ? ? 1_555 L CA . CA ? ? A GLY 344 A CA 470 1_555 ? ? ? ? ? ? ? 2.496 ? metalc7 metalc ? ? B ASP 255 OD2 ? ? ? 1_555 X CA . CA ? ? B ASP 324 B CA 472 1_555 ? ? ? ? ? ? ? 2.514 ? metalc8 metalc ? ? B THR 228 O ? ? ? 1_555 X CA . CA ? ? B THR 297 B CA 472 1_555 ? ? ? ? ? ? ? 2.583 ? metalc9 metalc ? ? A THR 228 O ? ? ? 1_555 L CA . CA ? ? A THR 297 A CA 470 1_555 ? ? ? ? ? ? ? 2.760 ? metalc10 metalc ? ? A ASP 255 OD2 ? ? ? 1_555 L CA . CA ? ? A ASP 324 A CA 470 1_555 ? ? ? ? ? ? ? 2.916 ? metalc11 metalc ? ? L CA . CA ? ? ? 1_555 Y HOH . O ? ? A CA 470 A HOH 529 1_555 ? ? ? ? ? ? ? 2.286 ? # loop_ _struct_conn_type.id _struct_conn_type.criteria _struct_conn_type.reference disulf ? ? covale ? ? metalc ? ? # loop_ _struct_mon_prot_cis.pdbx_id _struct_mon_prot_cis.label_comp_id _struct_mon_prot_cis.label_seq_id _struct_mon_prot_cis.label_asym_id _struct_mon_prot_cis.label_alt_id _struct_mon_prot_cis.pdbx_PDB_ins_code _struct_mon_prot_cis.auth_comp_id _struct_mon_prot_cis.auth_seq_id _struct_mon_prot_cis.auth_asym_id _struct_mon_prot_cis.pdbx_label_comp_id_2 _struct_mon_prot_cis.pdbx_label_seq_id_2 _struct_mon_prot_cis.pdbx_label_asym_id_2 _struct_mon_prot_cis.pdbx_PDB_ins_code_2 _struct_mon_prot_cis.pdbx_auth_comp_id_2 _struct_mon_prot_cis.pdbx_auth_seq_id_2 _struct_mon_prot_cis.pdbx_auth_asym_id_2 _struct_mon_prot_cis.pdbx_PDB_model_num _struct_mon_prot_cis.pdbx_omega_angle 1 GLN 69 A . ? GLN 138 A PRO 70 A ? PRO 139 A 1 -0.26 2 THR 256 A . ? THR 325 A PRO 257 A ? PRO 326 A 1 -0.51 3 GLN 69 B . ? GLN 138 B PRO 70 B ? PRO 139 B 1 4.55 4 THR 256 B . ? THR 325 B PRO 257 B ? PRO 326 B 1 -0.12 # loop_ _struct_sheet.id _struct_sheet.type _struct_sheet.number_strands _struct_sheet.details A ? 4 ? B ? 4 ? C ? 4 ? D ? 3 ? E ? 4 ? F ? 5 ? G ? 4 ? H ? 4 ? I ? 4 ? J ? 4 ? K ? 3 ? L ? 4 ? M ? 5 ? N ? 4 ? # loop_ _struct_sheet_order.sheet_id _struct_sheet_order.range_id_1 _struct_sheet_order.range_id_2 _struct_sheet_order.offset _struct_sheet_order.sense A 1 2 ? anti-parallel A 2 3 ? anti-parallel A 3 4 ? anti-parallel B 1 2 ? anti-parallel B 2 3 ? anti-parallel B 3 4 ? anti-parallel C 1 2 ? anti-parallel C 2 3 ? anti-parallel C 3 4 ? anti-parallel D 1 2 ? anti-parallel D 2 3 ? anti-parallel E 1 2 ? anti-parallel E 2 3 ? anti-parallel E 3 4 ? anti-parallel F 1 2 ? parallel F 2 3 ? anti-parallel F 3 4 ? anti-parallel F 4 5 ? anti-parallel G 1 2 ? anti-parallel G 2 3 ? anti-parallel G 3 4 ? anti-parallel H 1 2 ? anti-parallel H 2 3 ? anti-parallel H 3 4 ? anti-parallel I 1 2 ? anti-parallel I 2 3 ? anti-parallel I 3 4 ? anti-parallel J 1 2 ? anti-parallel J 2 3 ? anti-parallel J 3 4 ? anti-parallel K 1 2 ? anti-parallel K 2 3 ? anti-parallel L 1 2 ? anti-parallel L 2 3 ? anti-parallel L 3 4 ? anti-parallel M 1 2 ? parallel M 2 3 ? anti-parallel M 3 4 ? anti-parallel M 4 5 ? anti-parallel N 1 2 ? anti-parallel N 2 3 ? anti-parallel N 3 4 ? anti-parallel # loop_ _struct_sheet_range.sheet_id _struct_sheet_range.id _struct_sheet_range.beg_label_comp_id _struct_sheet_range.beg_label_asym_id _struct_sheet_range.beg_label_seq_id _struct_sheet_range.pdbx_beg_PDB_ins_code _struct_sheet_range.end_label_comp_id _struct_sheet_range.end_label_asym_id _struct_sheet_range.end_label_seq_id _struct_sheet_range.pdbx_end_PDB_ins_code _struct_sheet_range.beg_auth_comp_id _struct_sheet_range.beg_auth_asym_id _struct_sheet_range.beg_auth_seq_id _struct_sheet_range.end_auth_comp_id _struct_sheet_range.end_auth_asym_id _struct_sheet_range.end_auth_seq_id A 1 PHE A 23 ? ILE A 29 ? PHE A 92 ILE A 98 A 2 SER A 371 ? LEU A 379 ? SER A 440 LEU A 448 A 3 ASP A 352 ? HIS A 362 ? ASP A 421 HIS A 431 A 4 SER A 341 ? LYS A 347 ? SER A 410 LYS A 416 B 1 LEU A 44 ? CYS A 53 ? LEU A 113 CYS A 122 B 2 CYS A 58 ? ALA A 68 ? CYS A 127 ALA A 137 B 3 HIS A 86 ? LYS A 91 ? HIS A 155 LYS A 160 B 4 ILE A 102 ? ALA A 106 ? ILE A 171 ALA A 175 C 1 SER A 109 ? HIS A 114 ? SER A 178 HIS A 183 C 2 TRP A 119 ? ASP A 125 ? TRP A 188 ASP A 194 C 3 LEU A 132 ? TYR A 137 ? LEU A 201 TYR A 206 C 4 ALA A 140 ? HIS A 146 ? ALA A 209 HIS A 215 D 1 ARG A 154 ? THR A 155 ? ARG A 223 THR A 224 D 2 ASN A 166 ? THR A 172 ? ASN A 235 THR A 241 D 3 ASN A 161 ? ILE A 163 ? ASN A 230 ILE A 232 E 1 ARG A 154 ? THR A 155 ? ARG A 223 THR A 224 E 2 ASN A 166 ? THR A 172 ? ASN A 235 THR A 241 E 3 ARG A 183 ? ARG A 188 ? ARG A 252 ARG A 257 E 4 ARG A 191 ? ILE A 196 ? ARG A 260 ILE A 265 F 1 THR A 199 ? GLY A 200 ? THR A 268 GLY A 269 F 2 THR A 242 ? LEU A 247 ? THR A 311 LEU A 316 F 3 PRO A 232 ? ASN A 237 ? PRO A 301 ASN A 306 F 4 THR A 217 ? ARG A 223 ? THR A 286 ARG A 292 F 5 GLU A 206 ? PHE A 212 ? GLU A 275 PHE A 281 G 1 PHE A 283 ? MET A 288 ? PHE A 352 MET A 357 G 2 LYS A 291 ? ARG A 298 ? LYS A 360 ARG A 367 G 3 MET A 306 ? TYR A 314 ? MET A 375 TYR A 383 G 4 ALA A 326 ? PRO A 337 ? ALA A 395 PRO A 406 H 1 PHE B 23 ? ILE B 29 ? PHE B 92 ILE B 98 H 2 SER B 371 ? LEU B 379 ? SER B 440 LEU B 448 H 3 ASP B 352 ? HIS B 362 ? ASP B 421 HIS B 431 H 4 SER B 341 ? LYS B 347 ? SER B 410 LYS B 416 I 1 LEU B 44 ? CYS B 53 ? LEU B 113 CYS B 122 I 2 CYS B 58 ? ALA B 68 ? CYS B 127 ALA B 137 I 3 HIS B 86 ? LYS B 91 ? HIS B 155 LYS B 160 I 4 ILE B 102 ? ALA B 106 ? ILE B 171 ALA B 175 J 1 SER B 109 ? HIS B 114 ? SER B 178 HIS B 183 J 2 TRP B 119 ? ASP B 125 ? TRP B 188 ASP B 194 J 3 LEU B 132 ? TYR B 137 ? LEU B 201 TYR B 206 J 4 ALA B 140 ? HIS B 146 ? ALA B 209 HIS B 215 K 1 ARG B 154 ? THR B 155 ? ARG B 223 THR B 224 K 2 ASN B 166 ? THR B 172 ? ASN B 235 THR B 241 K 3 ASN B 161 ? ILE B 163 ? ASN B 230 ILE B 232 L 1 ARG B 154 ? THR B 155 ? ARG B 223 THR B 224 L 2 ASN B 166 ? THR B 172 ? ASN B 235 THR B 241 L 3 ARG B 183 ? ARG B 188 ? ARG B 252 ARG B 257 L 4 ARG B 191 ? ILE B 196 ? ARG B 260 ILE B 265 M 1 THR B 199 ? GLY B 200 ? THR B 268 GLY B 269 M 2 THR B 242 ? LEU B 247 ? THR B 311 LEU B 316 M 3 PRO B 232 ? ASN B 237 ? PRO B 301 ASN B 306 M 4 THR B 217 ? ARG B 223 ? THR B 286 ARG B 292 M 5 GLU B 206 ? PHE B 212 ? GLU B 275 PHE B 281 N 1 PHE B 283 ? ARG B 287 ? PHE B 352 ARG B 356 N 2 ILE B 292 ? ARG B 298 ? ILE B 361 ARG B 367 N 3 MET B 306 ? TYR B 314 ? MET B 375 TYR B 383 N 4 ALA B 326 ? PRO B 337 ? ALA B 395 PRO B 406 # loop_ _pdbx_struct_sheet_hbond.sheet_id _pdbx_struct_sheet_hbond.range_id_1 _pdbx_struct_sheet_hbond.range_id_2 _pdbx_struct_sheet_hbond.range_1_label_atom_id _pdbx_struct_sheet_hbond.range_1_label_comp_id _pdbx_struct_sheet_hbond.range_1_label_asym_id _pdbx_struct_sheet_hbond.range_1_label_seq_id _pdbx_struct_sheet_hbond.range_1_PDB_ins_code _pdbx_struct_sheet_hbond.range_1_auth_atom_id _pdbx_struct_sheet_hbond.range_1_auth_comp_id _pdbx_struct_sheet_hbond.range_1_auth_asym_id _pdbx_struct_sheet_hbond.range_1_auth_seq_id _pdbx_struct_sheet_hbond.range_2_label_atom_id _pdbx_struct_sheet_hbond.range_2_label_comp_id _pdbx_struct_sheet_hbond.range_2_label_asym_id _pdbx_struct_sheet_hbond.range_2_label_seq_id _pdbx_struct_sheet_hbond.range_2_PDB_ins_code _pdbx_struct_sheet_hbond.range_2_auth_atom_id _pdbx_struct_sheet_hbond.range_2_auth_comp_id _pdbx_struct_sheet_hbond.range_2_auth_asym_id _pdbx_struct_sheet_hbond.range_2_auth_seq_id A 1 2 N LEU A 27 ? N LEU A 96 O ILE A 376 ? O ILE A 445 A 2 3 O TYR A 377 ? O TYR A 446 N ILE A 356 ? N ILE A 425 A 3 4 O GLY A 357 ? O GLY A 426 N PHE A 342 ? N PHE A 411 B 1 2 N ALA A 52 ? N ALA A 121 O LYS A 59 ? O LYS A 128 B 2 3 N HIS A 60 ? N HIS A 129 O VAL A 90 ? O VAL A 159 B 3 4 N LEU A 87 ? N LEU A 156 O HIS A 104 ? O HIS A 173 C 1 2 N CYS A 113 ? N CYS A 182 O THR A 120 ? O THR A 189 C 2 3 N ASP A 125 ? N ASP A 194 O LEU A 132 ? O LEU A 201 C 3 4 N ILE A 135 ? N ILE A 204 O THR A 142 ? O THR A 211 D 1 2 N ARG A 154 ? N ARG A 223 O THR A 172 ? O THR A 241 D 2 3 O TYR A 168 ? O TYR A 237 N ASN A 161 ? N ASN A 230 E 1 2 N ARG A 154 ? N ARG A 223 O THR A 172 ? O THR A 241 E 2 3 N CYS A 167 ? N CYS A 236 O ILE A 187 ? O ILE A 256 E 3 4 N PHE A 184 ? N PHE A 253 O ILE A 196 ? O ILE A 265 F 1 2 N THR A 199 ? N THR A 268 O ILE A 245 ? O ILE A 314 F 2 3 O ARG A 246 ? O ARG A 315 N PHE A 233 ? N PHE A 302 F 3 4 O LEU A 236 ? O LEU A 305 N ILE A 218 ? N ILE A 287 F 4 5 O GLU A 219 ? O GLU A 288 N GLY A 211 ? N GLY A 280 G 1 2 N VAL A 284 ? N VAL A 353 O TRP A 295 ? O TRP A 364 G 2 3 N ARG A 298 ? N ARG A 367 O GLY A 309 ? O GLY A 378 G 3 4 N LEU A 310 ? N LEU A 379 O SER A 328 ? O SER A 397 H 1 2 N ILE B 29 ? N ILE B 98 O THR B 374 ? O THR B 443 H 2 3 O TYR B 377 ? O TYR B 446 N ILE B 356 ? N ILE B 425 H 3 4 O VAL B 353 ? O VAL B 422 N ILE B 346 ? N ILE B 415 I 1 2 N ALA B 52 ? N ALA B 121 O LYS B 59 ? O LYS B 128 I 2 3 N HIS B 60 ? N HIS B 129 O VAL B 90 ? O VAL B 159 I 3 4 N LEU B 87 ? N LEU B 156 O HIS B 104 ? O HIS B 173 J 1 2 N SER B 111 ? N SER B 180 O ILE B 122 ? O ILE B 191 J 2 3 N ASP B 125 ? N ASP B 194 O LEU B 132 ? O LEU B 201 J 3 4 N ILE B 135 ? N ILE B 204 O THR B 142 ? O THR B 211 K 1 2 N ARG B 154 ? N ARG B 223 O THR B 172 ? O THR B 241 K 2 3 O TYR B 168 ? O TYR B 237 N ASN B 161 ? N ASN B 230 L 1 2 N ARG B 154 ? N ARG B 223 O THR B 172 ? O THR B 241 L 2 3 N CYS B 167 ? N CYS B 236 O ILE B 187 ? O ILE B 256 L 3 4 N PHE B 184 ? N PHE B 253 O ILE B 196 ? O ILE B 265 M 1 2 N THR B 199 ? N THR B 268 O ILE B 245 ? O ILE B 314 M 2 3 O THR B 242 ? O THR B 311 N ASN B 237 ? N ASN B 306 M 3 4 O LEU B 236 ? O LEU B 305 N ILE B 218 ? N ILE B 287 M 4 5 O ARG B 223 ? O ARG B 292 N GLU B 206 ? N GLU B 275 N 1 2 N GLN B 286 ? N GLN B 355 O GLY B 293 ? O GLY B 362 N 2 3 N TYR B 296 ? N TYR B 365 O TYR B 311 ? O TYR B 380 N 3 4 N VAL B 312 ? N VAL B 381 O ALA B 326 ? O ALA B 395 # loop_ _struct_site.id _struct_site.pdbx_evidence_code _struct_site.pdbx_auth_asym_id _struct_site.pdbx_auth_comp_id _struct_site.pdbx_auth_seq_id _struct_site.pdbx_auth_ins_code _struct_site.pdbx_num_residues _struct_site.details AC1 Software ? ? ? ? 6 'BINDING SITE FOR RESIDUE NAG A 1' AC2 Software ? ? ? ? 7 'BINDING SITE FOR RESIDUE NAG A 2' AC3 Software ? ? ? ? 2 'BINDING SITE FOR RESIDUE BMA A 3' AC4 Software ? ? ? ? 8 'BINDING SITE FOR RESIDUE MAN A 4' AC5 Software ? ? ? ? 5 'BINDING SITE FOR RESIDUE MAN A 5' AC6 Software ? ? ? ? 3 'BINDING SITE FOR RESIDUE MAN A 6' AC7 Software ? ? ? ? 5 'BINDING SITE FOR RESIDUE SO4 A 467' AC8 Software ? ? ? ? 8 'BINDING SITE FOR RESIDUE EDO A 468' AC9 Software ? ? ? ? 7 'BINDING SITE FOR RESIDUE GOL A 469' BC1 Software ? ? ? ? 6 'BINDING SITE FOR RESIDUE CA A 470' BC2 Software ? ? ? ? 6 'BINDING SITE FOR RESIDUE NAG B 1' BC3 Software ? ? ? ? 6 'BINDING SITE FOR RESIDUE NAG B 2' BC4 Software ? ? ? ? 3 'BINDING SITE FOR RESIDUE BMA B 3' BC5 Software ? ? ? ? 9 'BINDING SITE FOR RESIDUE MAN B 4' BC6 Software ? ? ? ? 7 'BINDING SITE FOR RESIDUE MAN B 5' BC7 Software ? ? ? ? 2 'BINDING SITE FOR RESIDUE MAN B 6' BC8 Software ? ? ? ? 4 'BINDING SITE FOR RESIDUE SO4 B 467' BC9 Software ? ? ? ? 3 'BINDING SITE FOR RESIDUE EDO B 468' CC1 Software ? ? ? ? 4 'BINDING SITE FOR RESIDUE GOL B 469' CC2 Software ? ? ? ? 8 'BINDING SITE FOR RESIDUE GOL B 470' CC3 Software ? ? ? ? 8 'BINDING SITE FOR RESIDUE GOL B 471' CC4 Software ? ? ? ? 5 'BINDING SITE FOR RESIDUE CA B 472' # loop_ _struct_site_gen.id _struct_site_gen.site_id _struct_site_gen.pdbx_num_res _struct_site_gen.label_comp_id _struct_site_gen.label_asym_id _struct_site_gen.label_seq_id _struct_site_gen.pdbx_auth_ins_code _struct_site_gen.auth_comp_id _struct_site_gen.auth_asym_id _struct_site_gen.auth_seq_id _struct_site_gen.label_atom_id _struct_site_gen.label_alt_id _struct_site_gen.symmetry _struct_site_gen.details 1 AC1 6 NAG D . ? NAG A 2 . ? 1_555 ? 2 AC1 6 PRO A 14 ? PRO A 83 . ? 1_555 ? 3 AC1 6 ARG A 15 ? ARG A 84 . ? 1_555 ? 4 AC1 6 ASN A 215 ? ASN A 284 . ? 1_555 ? 5 AC1 6 ARG A 287 ? ARG A 356 . ? 1_555 ? 6 AC1 6 HOH Y . ? HOH A 489 . ? 1_555 ? 7 AC2 7 NAG C . ? NAG A 1 . ? 1_555 ? 8 AC2 7 BMA E . ? BMA A 3 . ? 1_555 ? 9 AC2 7 MAN F . ? MAN A 4 . ? 1_555 ? 10 AC2 7 MAN H . ? MAN A 6 . ? 1_555 ? 11 AC2 7 LEU A 16 ? LEU A 85 . ? 1_555 ? 12 AC2 7 HOH Y . ? HOH A 489 . ? 1_555 ? 13 AC2 7 TYR B 13 ? TYR B 82 . ? 6_544 ? 14 AC3 2 NAG D . ? NAG A 2 . ? 1_555 ? 15 AC3 2 MAN F . ? MAN A 4 . ? 1_555 ? 16 AC4 8 NAG D . ? NAG A 2 . ? 1_555 ? 17 AC4 8 BMA E . ? BMA A 3 . ? 1_555 ? 18 AC4 8 MAN G . ? MAN A 5 . ? 1_555 ? 19 AC4 8 MAN H . ? MAN A 6 . ? 1_555 ? 20 AC4 8 TRP B 11 ? TRP B 80 . ? 6_544 ? 21 AC4 8 TYR B 13 ? TYR B 82 . ? 6_544 ? 22 AC4 8 GLY B 164 ? GLY B 233 . ? 6_544 ? 23 AC4 8 ARG B 188 ? ARG B 257 . ? 6_544 ? 24 AC5 5 MAN F . ? MAN A 4 . ? 1_555 ? 25 AC5 5 ASN B 166 ? ASN B 235 . ? 6_544 ? 26 AC5 5 TYR B 168 ? TYR B 237 . ? 6_544 ? 27 AC5 5 LYS B 186 ? LYS B 255 . ? 6_544 ? 28 AC5 5 VAL B 238 ? VAL B 307 . ? 6_544 ? 29 AC6 3 NAG D . ? NAG A 2 . ? 1_555 ? 30 AC6 3 MAN F . ? MAN A 4 . ? 1_555 ? 31 AC6 3 GLU B 10 ? GLU B 79 . ? 6_544 ? 32 AC7 5 ARG A 47 ? ARG A 116 . ? 1_555 ? 33 AC7 5 ARG A 223 ? ARG A 292 . ? 1_555 ? 34 AC7 5 ARG A 305 ? ARG A 374 . ? 1_555 ? 35 AC7 5 TYR A 340 ? TYR A 409 . ? 1_555 ? 36 AC7 5 HOH Y . ? HOH A 565 . ? 1_555 ? 37 AC8 8 HOH Y . ? HOH A 62 . ? 1_555 ? 38 AC8 8 CYS A 53 ? CYS A 122 . ? 1_555 ? 39 AC8 8 GLY A 54 ? GLY A 123 . ? 1_555 ? 40 AC8 8 PRO A 55 ? PRO A 124 . ? 1_555 ? 41 AC8 8 LYS A 56 ? LYS A 125 . ? 1_555 ? 42 AC8 8 CYS A 58 ? CYS A 127 . ? 1_555 ? 43 AC8 8 GLU A 139 ? GLU A 208 . ? 3_545 ? 44 AC8 8 LYS A 347 ? LYS A 416 . ? 1_555 ? 45 AC9 7 SER A 301 ? SER A 370 . ? 1_555 ? 46 AC9 7 THR A 303 ? THR A 372 . ? 1_555 ? 47 AC9 7 LYS A 304 ? LYS A 373 . ? 1_555 ? 48 AC9 7 HOH Y . ? HOH A 547 . ? 1_555 ? 49 AC9 7 ASP B 394 ? ASP B 463 . ? 1_555 ? 50 AC9 7 MET B 395 ? MET B 464 . ? 1_555 ? 51 AC9 7 ALA B 396 ? ALA B 465 . ? 1_555 ? 52 BC1 6 ASP A 224 ? ASP A 293 . ? 1_555 ? 53 BC1 6 THR A 228 ? THR A 297 . ? 1_555 ? 54 BC1 6 ASP A 255 ? ASP A 324 . ? 1_555 ? 55 BC1 6 GLY A 275 ? GLY A 344 . ? 1_555 ? 56 BC1 6 GLY A 277 ? GLY A 346 . ? 1_555 ? 57 BC1 6 HOH Y . ? HOH A 529 . ? 1_555 ? 58 BC2 6 NAG N . ? NAG B 2 . ? 1_555 ? 59 BC2 6 PRO B 14 ? PRO B 83 . ? 1_555 ? 60 BC2 6 LEU B 16 ? LEU B 85 . ? 1_555 ? 61 BC2 6 ASN B 215 ? ASN B 284 . ? 1_555 ? 62 BC2 6 ARG B 287 ? ARG B 356 . ? 1_555 ? 63 BC2 6 HOH Z . ? HOH B 539 . ? 1_555 ? 64 BC3 6 TYR A 13 ? TYR A 82 . ? 6_545 ? 65 BC3 6 NAG M . ? NAG B 1 . ? 1_555 ? 66 BC3 6 BMA O . ? BMA B 3 . ? 1_555 ? 67 BC3 6 MAN P . ? MAN B 4 . ? 1_555 ? 68 BC3 6 LEU B 16 ? LEU B 85 . ? 1_555 ? 69 BC3 6 HOH Z . ? HOH B 539 . ? 1_555 ? 70 BC4 3 NAG N . ? NAG B 2 . ? 1_555 ? 71 BC4 3 MAN P . ? MAN B 4 . ? 1_555 ? 72 BC4 3 MAN Q . ? MAN B 5 . ? 1_555 ? 73 BC5 9 TRP A 11 ? TRP A 80 . ? 6_545 ? 74 BC5 9 TYR A 13 ? TYR A 82 . ? 6_545 ? 75 BC5 9 GLY A 164 ? GLY A 233 . ? 6_545 ? 76 BC5 9 ASN A 166 ? ASN A 235 . ? 6_545 ? 77 BC5 9 ARG A 188 ? ARG A 257 . ? 6_545 ? 78 BC5 9 NAG N . ? NAG B 2 . ? 1_555 ? 79 BC5 9 BMA O . ? BMA B 3 . ? 1_555 ? 80 BC5 9 MAN Q . ? MAN B 5 . ? 1_555 ? 81 BC5 9 MAN R . ? MAN B 6 . ? 1_555 ? 82 BC6 7 ILE A 163 ? ILE A 232 . ? 6_545 ? 83 BC6 7 ASN A 166 ? ASN A 235 . ? 6_545 ? 84 BC6 7 LYS A 186 ? LYS A 255 . ? 6_545 ? 85 BC6 7 VAL A 238 ? VAL A 307 . ? 6_545 ? 86 BC6 7 HOH Y . ? HOH A 520 . ? 6_545 ? 87 BC6 7 BMA O . ? BMA B 3 . ? 1_555 ? 88 BC6 7 MAN P . ? MAN B 4 . ? 1_555 ? 89 BC7 2 GLU A 10 ? GLU A 79 . ? 6_545 ? 90 BC7 2 MAN P . ? MAN B 4 . ? 1_555 ? 91 BC8 4 ARG B 47 ? ARG B 116 . ? 1_555 ? 92 BC8 4 ARG B 223 ? ARG B 292 . ? 1_555 ? 93 BC8 4 ARG B 305 ? ARG B 374 . ? 1_555 ? 94 BC8 4 TYR B 340 ? TYR B 409 . ? 1_555 ? 95 BC9 3 VAL B 330 ? VAL B 399 . ? 1_555 ? 96 BC9 3 LEU B 385 ? LEU B 454 . ? 1_555 ? 97 BC9 3 LEU B 386 ? LEU B 455 . ? 1_555 ? 98 CC1 4 TYR B 145 ? TYR B 214 . ? 1_555 ? 99 CC1 4 HIS B 146 ? HIS B 215 . ? 1_555 ? 100 CC1 4 SER B 147 ? SER B 216 . ? 1_555 ? 101 CC1 4 TYR B 148 ? TYR B 217 . ? 1_555 ? 102 CC2 8 CYS B 53 ? CYS B 122 . ? 1_555 ? 103 CC2 8 GLY B 54 ? GLY B 123 . ? 1_555 ? 104 CC2 8 PRO B 55 ? PRO B 124 . ? 1_555 ? 105 CC2 8 CYS B 58 ? CYS B 127 . ? 1_555 ? 106 CC2 8 GLU B 139 ? GLU B 208 . ? 4_555 ? 107 CC2 8 ILE B 346 ? ILE B 415 . ? 1_555 ? 108 CC2 8 LYS B 347 ? LYS B 416 . ? 1_555 ? 109 CC2 8 HOH Z . ? HOH B 563 . ? 4_555 ? 110 CC3 8 ASP A 394 ? ASP A 463 . ? 1_555 ? 111 CC3 8 MET A 395 ? MET A 464 . ? 1_555 ? 112 CC3 8 ALA A 396 ? ALA A 465 . ? 1_555 ? 113 CC3 8 SER B 301 ? SER B 370 . ? 1_555 ? 114 CC3 8 LYS B 302 ? LYS B 371 . ? 1_555 ? 115 CC3 8 THR B 303 ? THR B 372 . ? 1_555 ? 116 CC3 8 LYS B 304 ? LYS B 373 . ? 1_555 ? 117 CC3 8 HOH Z . ? HOH B 535 . ? 1_555 ? 118 CC4 5 ASP B 224 ? ASP B 293 . ? 1_555 ? 119 CC4 5 THR B 228 ? THR B 297 . ? 1_555 ? 120 CC4 5 ASP B 255 ? ASP B 324 . ? 1_555 ? 121 CC4 5 GLY B 275 ? GLY B 344 . ? 1_555 ? 122 CC4 5 GLY B 277 ? GLY B 346 . ? 1_555 ? # _database_PDB_matrix.entry_id 3K36 _database_PDB_matrix.origx[1][1] 1.000000 _database_PDB_matrix.origx[1][2] 0.000000 _database_PDB_matrix.origx[1][3] 0.000000 _database_PDB_matrix.origx[2][1] 0.000000 _database_PDB_matrix.origx[2][2] 1.000000 _database_PDB_matrix.origx[2][3] 0.000000 _database_PDB_matrix.origx[3][1] 0.000000 _database_PDB_matrix.origx[3][2] 0.000000 _database_PDB_matrix.origx[3][3] 1.000000 _database_PDB_matrix.origx_vector[1] 0.00000 _database_PDB_matrix.origx_vector[2] 0.00000 _database_PDB_matrix.origx_vector[3] 0.00000 # _atom_sites.entry_id 3K36 _atom_sites.fract_transf_matrix[1][1] 0.011410 _atom_sites.fract_transf_matrix[1][2] 0.000000 _atom_sites.fract_transf_matrix[1][3] 0.000000 _atom_sites.fract_transf_matrix[2][1] 0.000000 _atom_sites.fract_transf_matrix[2][2] 0.011410 _atom_sites.fract_transf_matrix[2][3] 0.000000 _atom_sites.fract_transf_matrix[3][1] 0.000000 _atom_sites.fract_transf_matrix[3][2] 0.000000 _atom_sites.fract_transf_matrix[3][3] 0.005071 _atom_sites.fract_transf_vector[1] 0.00000 _atom_sites.fract_transf_vector[2] 0.00000 _atom_sites.fract_transf_vector[3] 0.00000 # loop_ _atom_type.symbol C CA N O S # loop_ _atom_site.group_PDB _atom_site.id _atom_site.type_symbol _atom_site.label_atom_id _atom_site.label_alt_id _atom_site.label_comp_id _atom_site.label_asym_id _atom_site.label_entity_id _atom_site.label_seq_id _atom_site.pdbx_PDB_ins_code _atom_site.Cartn_x _atom_site.Cartn_y _atom_site.Cartn_z _atom_site.occupancy _atom_site.B_iso_or_equiv _atom_site.pdbx_formal_charge _atom_site.auth_seq_id _atom_site.auth_comp_id _atom_site.auth_asym_id _atom_site.auth_atom_id _atom_site.pdbx_PDB_model_num ATOM 1 N N . PRO A 1 9 ? 38.840 -32.994 -67.705 1.00 40.17 ? 78 PRO A N 1 ATOM 2 C CA . PRO A 1 9 ? 37.408 -32.883 -67.435 1.00 40.01 ? 78 PRO A CA 1 ATOM 3 C C . PRO A 1 9 ? 36.790 -31.650 -68.090 1.00 39.50 ? 78 PRO A C 1 ATOM 4 O O . PRO A 1 9 ? 37.445 -31.005 -68.915 1.00 40.45 ? 78 PRO A O 1 ATOM 5 C CB . PRO A 1 9 ? 37.359 -32.788 -65.905 1.00 40.13 ? 78 PRO A CB 1 ATOM 6 C CG . PRO A 1 9 ? 38.547 -33.640 -65.441 1.00 40.45 ? 78 PRO A CG 1 ATOM 7 C CD . PRO A 1 9 ? 39.562 -33.645 -66.591 1.00 40.10 ? 78 PRO A CD 1 ATOM 8 N N . GLU A 1 10 ? 35.536 -31.347 -67.758 1.00 38.44 ? 79 GLU A N 1 ATOM 9 C CA . GLU A 1 10 ? 34.848 -30.161 -68.295 1.00 37.53 ? 79 GLU A CA 1 ATOM 10 C C . GLU A 1 10 ? 34.189 -29.339 -67.182 1.00 35.93 ? 79 GLU A C 1 ATOM 11 O O . GLU A 1 10 ? 33.877 -29.872 -66.116 1.00 35.55 ? 79 GLU A O 1 ATOM 12 C CB . GLU A 1 10 ? 33.804 -30.578 -69.338 1.00 37.82 ? 79 GLU A CB 1 ATOM 13 C CG . GLU A 1 10 ? 33.000 -29.421 -69.994 1.00 39.81 ? 79 GLU A CG 1 ATOM 14 C CD . GLU A 1 10 ? 33.857 -28.312 -70.655 1.00 42.34 ? 79 GLU A CD 1 ATOM 15 O OE1 . GLU A 1 10 ? 33.245 -27.322 -71.107 1.00 44.84 ? 79 GLU A OE1 1 ATOM 16 O OE2 . GLU A 1 10 ? 35.114 -28.395 -70.717 1.00 44.20 ? 79 GLU A OE2 1 ATOM 17 N N . TRP A 1 11 ? 34.004 -28.043 -67.443 1.00 33.90 ? 80 TRP A N 1 ATOM 18 C CA . TRP A 1 11 ? 33.349 -27.112 -66.517 1.00 32.40 ? 80 TRP A CA 1 ATOM 19 C C . TRP A 1 11 ? 31.941 -27.574 -66.089 1.00 31.14 ? 80 TRP A C 1 ATOM 20 O O . TRP A 1 11 ? 31.162 -28.025 -66.914 1.00 31.62 ? 80 TRP A O 1 ATOM 21 C CB . TRP A 1 11 ? 33.182 -25.741 -67.187 1.00 32.26 ? 80 TRP A CB 1 ATOM 22 C CG . TRP A 1 11 ? 34.437 -25.009 -67.597 1.00 31.70 ? 80 TRP A CG 1 ATOM 23 C CD1 . TRP A 1 11 ? 34.672 -24.423 -68.805 1.00 31.67 ? 80 TRP A CD1 1 ATOM 24 C CD2 . TRP A 1 11 ? 35.592 -24.734 -66.788 1.00 30.66 ? 80 TRP A CD2 1 ATOM 25 N NE1 . TRP A 1 11 ? 35.907 -23.813 -68.811 1.00 31.52 ? 80 TRP A NE1 1 ATOM 26 C CE2 . TRP A 1 11 ? 36.495 -23.990 -67.588 1.00 30.46 ? 80 TRP A CE2 1 ATOM 27 C CE3 . TRP A 1 11 ? 35.956 -25.046 -65.470 1.00 29.49 ? 80 TRP A CE3 1 ATOM 28 C CZ2 . TRP A 1 11 ? 37.737 -23.563 -67.119 1.00 28.92 ? 80 TRP A CZ2 1 ATOM 29 C CZ3 . TRP A 1 11 ? 37.186 -24.618 -65.005 1.00 29.30 ? 80 TRP A CZ3 1 ATOM 30 C CH2 . TRP A 1 11 ? 38.064 -23.881 -65.829 1.00 29.05 ? 80 TRP A CH2 1 ATOM 31 N N . THR A 1 12 ? 31.591 -27.402 -64.820 1.00 29.64 ? 81 THR A N 1 ATOM 32 C CA A THR A 1 12 ? 30.266 -27.734 -64.314 0.50 29.12 ? 81 THR A CA 1 ATOM 33 C CA B THR A 1 12 ? 30.252 -27.762 -64.385 0.50 29.02 ? 81 THR A CA 1 ATOM 34 C C . THR A 1 12 ? 29.258 -26.627 -64.641 1.00 28.54 ? 81 THR A C 1 ATOM 35 O O . THR A 1 12 ? 29.625 -25.463 -64.733 1.00 28.44 ? 81 THR A O 1 ATOM 36 C CB A THR A 1 12 ? 30.299 -27.963 -62.778 0.50 29.14 ? 81 THR A CB 1 ATOM 37 C CB B THR A 1 12 ? 30.217 -28.236 -62.917 0.50 29.00 ? 81 THR A CB 1 ATOM 38 O OG1 A THR A 1 12 ? 29.188 -28.773 -62.383 0.50 29.14 ? 81 THR A OG1 1 ATOM 39 O OG1 B THR A 1 12 ? 31.092 -27.432 -62.119 0.50 29.16 ? 81 THR A OG1 1 ATOM 40 C CG2 A THR A 1 12 ? 30.254 -26.639 -62.019 0.50 29.24 ? 81 THR A CG2 1 ATOM 41 C CG2 B THR A 1 12 ? 30.655 -29.687 -62.839 0.50 28.31 ? 81 THR A CG2 1 ATOM 42 N N . TYR A 1 13 ? 27.995 -27.014 -64.808 1.00 27.69 ? 82 TYR A N 1 ATOM 43 C CA . TYR A 1 13 ? 26.878 -26.128 -65.089 1.00 27.16 ? 82 TYR A CA 1 ATOM 44 C C . TYR A 1 13 ? 25.775 -26.679 -64.213 1.00 25.88 ? 82 TYR A C 1 ATOM 45 O O . TYR A 1 13 ? 25.786 -27.865 -63.957 1.00 25.27 ? 82 TYR A O 1 ATOM 46 C CB . TYR A 1 13 ? 26.465 -26.239 -66.585 1.00 27.76 ? 82 TYR A CB 1 ATOM 47 C CG . TYR A 1 13 ? 27.476 -25.621 -67.522 1.00 29.98 ? 82 TYR A CG 1 ATOM 48 C CD1 . TYR A 1 13 ? 27.313 -24.312 -67.988 1.00 31.74 ? 82 TYR A CD1 1 ATOM 49 C CD2 . TYR A 1 13 ? 28.613 -26.327 -67.921 1.00 31.85 ? 82 TYR A CD2 1 ATOM 50 C CE1 . TYR A 1 13 ? 28.262 -23.715 -68.844 1.00 33.60 ? 82 TYR A CE1 1 ATOM 51 C CE2 . TYR A 1 13 ? 29.569 -25.745 -68.775 1.00 33.49 ? 82 TYR A CE2 1 ATOM 52 C CZ . TYR A 1 13 ? 29.390 -24.431 -69.229 1.00 33.70 ? 82 TYR A CZ 1 ATOM 53 O OH . TYR A 1 13 ? 30.326 -23.828 -70.058 1.00 33.91 ? 82 TYR A OH 1 ATOM 54 N N . PRO A 1 14 ? 24.813 -25.840 -63.758 1.00 25.09 ? 83 PRO A N 1 ATOM 55 C CA . PRO A 1 14 ? 23.623 -26.418 -63.116 1.00 24.62 ? 83 PRO A CA 1 ATOM 56 C C . PRO A 1 14 ? 22.752 -27.166 -64.130 1.00 24.12 ? 83 PRO A C 1 ATOM 57 O O . PRO A 1 14 ? 22.552 -26.676 -65.242 1.00 23.60 ? 83 PRO A O 1 ATOM 58 C CB . PRO A 1 14 ? 22.874 -25.183 -62.608 1.00 24.48 ? 83 PRO A CB 1 ATOM 59 C CG . PRO A 1 14 ? 23.273 -24.107 -63.536 1.00 24.43 ? 83 PRO A CG 1 ATOM 60 C CD . PRO A 1 14 ? 24.724 -24.370 -63.803 1.00 24.73 ? 83 PRO A CD 1 ATOM 61 N N . ARG A 1 15 ? 22.275 -28.348 -63.761 1.00 23.62 ? 84 ARG A N 1 ATOM 62 C CA . ARG A 1 15 ? 21.357 -29.112 -64.599 1.00 22.96 ? 84 ARG A CA 1 ATOM 63 C C . ARG A 1 15 ? 20.007 -29.008 -63.956 1.00 22.13 ? 84 ARG A C 1 ATOM 64 O O . ARG A 1 15 ? 19.860 -28.356 -62.929 1.00 21.90 ? 84 ARG A O 1 ATOM 65 C CB . ARG A 1 15 ? 21.720 -30.590 -64.655 1.00 23.04 ? 84 ARG A CB 1 ATOM 66 C CG . ARG A 1 15 ? 23.093 -30.939 -65.166 1.00 24.44 ? 84 ARG A CG 1 ATOM 67 C CD . ARG A 1 15 ? 23.712 -31.868 -64.177 1.00 27.10 ? 84 ARG A CD 1 ATOM 68 N NE . ARG A 1 15 ? 24.141 -33.135 -64.723 1.00 30.12 ? 84 ARG A NE 1 ATOM 69 C CZ . ARG A 1 15 ? 24.623 -34.124 -63.973 1.00 32.36 ? 84 ARG A CZ 1 ATOM 70 N NH1 . ARG A 1 15 ? 24.741 -33.999 -62.644 1.00 33.65 ? 84 ARG A NH1 1 ATOM 71 N NH2 . ARG A 1 15 ? 24.995 -35.243 -64.551 1.00 32.36 ? 84 ARG A NH2 1 ATOM 72 N N . LEU A 1 16 ? 19.029 -29.663 -64.568 1.00 21.36 ? 85 LEU A N 1 ATOM 73 C CA . LEU A 1 16 ? 17.696 -29.786 -64.008 1.00 21.08 ? 85 LEU A CA 1 ATOM 74 C C . LEU A 1 16 ? 17.783 -30.748 -62.828 1.00 21.24 ? 85 LEU A C 1 ATOM 75 O O . LEU A 1 16 ? 18.710 -31.571 -62.750 1.00 19.86 ? 85 LEU A O 1 ATOM 76 C CB . LEU A 1 16 ? 16.703 -30.277 -65.068 1.00 20.64 ? 85 LEU A CB 1 ATOM 77 C CG . LEU A 1 16 ? 15.635 -29.299 -65.576 1.00 20.18 ? 85 LEU A CG 1 ATOM 78 C CD1 . LEU A 1 16 ? 16.094 -27.852 -65.680 1.00 17.74 ? 85 LEU A CD1 1 ATOM 79 C CD2 . LEU A 1 16 ? 15.096 -29.816 -66.906 1.00 18.92 ? 85 LEU A CD2 1 ATOM 80 N N . SER A 1 17 ? 16.856 -30.621 -61.888 1.00 21.27 ? 86 SER A N 1 ATOM 81 C CA . SER A 1 17 ? 16.945 -31.447 -60.684 1.00 21.96 ? 86 SER A CA 1 ATOM 82 C C . SER A 1 17 ? 16.329 -32.824 -60.899 1.00 22.48 ? 86 SER A C 1 ATOM 83 O O . SER A 1 17 ? 15.417 -33.005 -61.712 1.00 22.96 ? 86 SER A O 1 ATOM 84 C CB . SER A 1 17 ? 16.350 -30.758 -59.455 1.00 21.66 ? 86 SER A CB 1 ATOM 85 O OG . SER A 1 17 ? 17.215 -29.734 -58.990 1.00 22.62 ? 86 SER A OG 1 ATOM 86 N N . CYS A 1 18 ? 16.861 -33.798 -60.163 1.00 22.99 ? 87 CYS A N 1 ATOM 87 C CA . CYS A 1 18 ? 16.373 -35.151 -60.193 1.00 23.22 ? 87 CYS A CA 1 ATOM 88 C C . CYS A 1 18 ? 14.913 -35.183 -59.727 1.00 23.87 ? 87 CYS A C 1 ATOM 89 O O . CYS A 1 18 ? 14.458 -34.269 -59.021 1.00 23.68 ? 87 CYS A O 1 ATOM 90 C CB . CYS A 1 18 ? 17.259 -36.050 -59.320 1.00 23.31 ? 87 CYS A CB 1 ATOM 91 S SG . CYS A 1 18 ? 19.031 -36.242 -59.821 1.00 24.23 ? 87 CYS A SG 1 ATOM 92 N N . PRO A 1 19 ? 14.156 -36.207 -60.164 1.00 24.46 ? 88 PRO A N 1 ATOM 93 C CA . PRO A 1 19 ? 12.755 -36.348 -59.782 1.00 24.33 ? 88 PRO A CA 1 ATOM 94 C C . PRO A 1 19 ? 12.560 -36.495 -58.268 1.00 23.84 ? 88 PRO A C 1 ATOM 95 O O . PRO A 1 19 ? 13.376 -37.133 -57.595 1.00 23.79 ? 88 PRO A O 1 ATOM 96 C CB . PRO A 1 19 ? 12.323 -37.648 -60.472 1.00 24.70 ? 88 PRO A CB 1 ATOM 97 C CG . PRO A 1 19 ? 13.346 -37.927 -61.515 1.00 25.60 ? 88 PRO A CG 1 ATOM 98 C CD . PRO A 1 19 ? 14.606 -37.290 -61.067 1.00 25.09 ? 88 PRO A CD 1 ATOM 99 N N . GLY A 1 20 ? 11.482 -35.910 -57.754 1.00 23.13 ? 89 GLY A N 1 ATOM 100 C CA . GLY A 1 20 ? 11.094 -36.102 -56.358 1.00 22.61 ? 89 GLY A CA 1 ATOM 101 C C . GLY A 1 20 ? 10.236 -34.960 -55.889 1.00 21.84 ? 89 GLY A C 1 ATOM 102 O O . GLY A 1 20 ? 10.133 -33.947 -56.552 1.00 21.62 ? 89 GLY A O 1 ATOM 103 N N . SER A 1 21 ? 9.610 -35.114 -54.735 1.00 21.44 ? 90 SER A N 1 ATOM 104 C CA . SER A 1 21 ? 8.780 -34.040 -54.226 1.00 20.96 ? 90 SER A CA 1 ATOM 105 C C . SER A 1 21 ? 8.727 -33.955 -52.705 1.00 20.83 ? 90 SER A C 1 ATOM 106 O O . SER A 1 21 ? 7.890 -33.241 -52.162 1.00 20.68 ? 90 SER A O 1 ATOM 107 C CB . SER A 1 21 ? 7.379 -34.155 -54.839 1.00 20.77 ? 90 SER A CB 1 ATOM 108 O OG . SER A 1 21 ? 6.916 -35.492 -54.744 1.00 21.26 ? 90 SER A OG 1 ATOM 109 N N . THR A 1 22 ? 9.619 -34.677 -52.020 1.00 20.70 ? 91 THR A N 1 ATOM 110 C CA . THR A 1 22 ? 9.858 -34.458 -50.605 1.00 20.22 ? 91 THR A CA 1 ATOM 111 C C . THR A 1 22 ? 11.314 -34.648 -50.255 1.00 19.79 ? 91 THR A C 1 ATOM 112 O O . THR A 1 22 ? 12.066 -35.273 -50.995 1.00 19.52 ? 91 THR A O 1 ATOM 113 C CB . THR A 1 22 ? 9.048 -35.405 -49.747 1.00 20.46 ? 91 THR A CB 1 ATOM 114 O OG1 . THR A 1 22 ? 9.038 -34.918 -48.391 1.00 21.88 ? 91 THR A OG1 1 ATOM 115 C CG2 . THR A 1 22 ? 9.625 -36.820 -49.811 1.00 19.82 ? 91 THR A CG2 1 ATOM 116 N N . PHE A 1 23 ? 11.713 -34.091 -49.119 1.00 19.69 ? 92 PHE A N 1 ATOM 117 C CA . PHE A 1 23 ? 13.040 -34.361 -48.539 1.00 19.19 ? 92 PHE A CA 1 ATOM 118 C C . PHE A 1 23 ? 12.868 -35.416 -47.480 1.00 19.01 ? 92 PHE A C 1 ATOM 119 O O . PHE A 1 23 ? 11.804 -35.472 -46.840 1.00 18.29 ? 92 PHE A O 1 ATOM 120 C CB . PHE A 1 23 ? 13.632 -33.119 -47.889 1.00 19.02 ? 92 PHE A CB 1 ATOM 121 C CG . PHE A 1 23 ? 14.260 -32.173 -48.843 1.00 18.57 ? 92 PHE A CG 1 ATOM 122 C CD1 . PHE A 1 23 ? 13.625 -31.819 -50.024 1.00 19.03 ? 92 PHE A CD1 1 ATOM 123 C CD2 . PHE A 1 23 ? 15.491 -31.621 -48.569 1.00 17.35 ? 92 PHE A CD2 1 ATOM 124 C CE1 . PHE A 1 23 ? 14.228 -30.926 -50.916 1.00 17.35 ? 92 PHE A CE1 1 ATOM 125 C CE2 . PHE A 1 23 ? 16.086 -30.734 -49.473 1.00 17.62 ? 92 PHE A CE2 1 ATOM 126 C CZ . PHE A 1 23 ? 15.445 -30.395 -50.638 1.00 15.08 ? 92 PHE A CZ 1 ATOM 127 N N . GLN A 1 24 ? 13.916 -36.237 -47.316 1.00 19.09 ? 93 GLN A N 1 ATOM 128 C CA . GLN A 1 24 ? 14.033 -37.224 -46.241 1.00 18.99 ? 93 GLN A CA 1 ATOM 129 C C . GLN A 1 24 ? 15.418 -37.147 -45.608 1.00 18.82 ? 93 GLN A C 1 ATOM 130 O O . GLN A 1 24 ? 16.379 -36.674 -46.233 1.00 18.19 ? 93 GLN A O 1 ATOM 131 C CB . GLN A 1 24 ? 13.806 -38.657 -46.744 1.00 19.26 ? 93 GLN A CB 1 ATOM 132 C CG . GLN A 1 24 ? 12.499 -38.877 -47.525 1.00 20.86 ? 93 GLN A CG 1 ATOM 133 C CD . GLN A 1 24 ? 11.275 -38.993 -46.641 1.00 22.96 ? 93 GLN A CD 1 ATOM 134 O OE1 . GLN A 1 24 ? 11.354 -38.806 -45.423 1.00 23.78 ? 93 GLN A OE1 1 ATOM 135 N NE2 . GLN A 1 24 ? 10.125 -39.322 -47.255 1.00 22.46 ? 93 GLN A NE2 1 ATOM 136 N N . LYS A 1 25 ? 15.476 -37.599 -44.350 1.00 18.48 ? 94 LYS A N 1 ATOM 137 C CA . LYS A 1 25 ? 16.708 -37.753 -43.575 1.00 17.86 ? 94 LYS A CA 1 ATOM 138 C C . LYS A 1 25 ? 17.663 -38.656 -44.315 1.00 16.99 ? 94 LYS A C 1 ATOM 139 O O . LYS A 1 25 ? 17.304 -39.770 -44.645 1.00 16.86 ? 94 LYS A O 1 ATOM 140 C CB . LYS A 1 25 ? 16.388 -38.353 -42.196 1.00 17.76 ? 94 LYS A CB 1 ATOM 141 C CG . LYS A 1 25 ? 17.605 -38.626 -41.266 1.00 18.20 ? 94 LYS A CG 1 ATOM 142 C CD . LYS A 1 25 ? 17.100 -39.174 -39.957 1.00 19.27 ? 94 LYS A CD 1 ATOM 143 C CE . LYS A 1 25 ? 18.202 -39.594 -39.003 1.00 21.46 ? 94 LYS A CE 1 ATOM 144 N NZ . LYS A 1 25 ? 17.656 -39.909 -37.613 1.00 19.19 ? 94 LYS A NZ 1 ATOM 145 N N . ALA A 1 26 ? 18.875 -38.165 -44.568 1.00 16.87 ? 95 ALA A N 1 ATOM 146 C CA . ALA A 1 26 ? 19.869 -38.872 -45.395 1.00 16.73 ? 95 ALA A CA 1 ATOM 147 C C . ALA A 1 26 ? 21.003 -39.468 -44.591 1.00 17.01 ? 95 ALA A C 1 ATOM 148 O O . ALA A 1 26 ? 21.379 -40.620 -44.815 1.00 17.35 ? 95 ALA A O 1 ATOM 149 C CB . ALA A 1 26 ? 20.435 -37.933 -46.466 1.00 16.55 ? 95 ALA A CB 1 ATOM 150 N N . LEU A 1 27 ? 21.528 -38.682 -43.635 1.00 17.20 ? 96 LEU A N 1 ATOM 151 C CA . LEU A 1 27 ? 22.865 -38.900 -43.086 1.00 16.69 ? 96 LEU A CA 1 ATOM 152 C C . LEU A 1 27 ? 23.163 -38.000 -41.861 1.00 15.41 ? 96 LEU A C 1 ATOM 153 O O . LEU A 1 27 ? 22.990 -36.785 -41.915 1.00 15.74 ? 96 LEU A O 1 ATOM 154 C CB . LEU A 1 27 ? 23.883 -38.645 -44.195 1.00 16.95 ? 96 LEU A CB 1 ATOM 155 C CG . LEU A 1 27 ? 25.289 -39.241 -44.065 1.00 19.09 ? 96 LEU A CG 1 ATOM 156 C CD1 . LEU A 1 27 ? 26.290 -38.211 -43.617 1.00 23.12 ? 96 LEU A CD1 1 ATOM 157 C CD2 . LEU A 1 27 ? 25.273 -40.428 -43.121 1.00 19.61 ? 96 LEU A CD2 1 ATOM 158 N N . LEU A 1 28 ? 23.576 -38.598 -40.753 1.00 14.37 ? 97 LEU A N 1 ATOM 159 C CA . LEU A 1 28 ? 24.079 -37.835 -39.599 1.00 14.14 ? 97 LEU A CA 1 ATOM 160 C C . LEU A 1 28 ? 25.602 -38.058 -39.443 1.00 14.72 ? 97 LEU A C 1 ATOM 161 O O . LEU A 1 28 ? 26.060 -39.190 -39.424 1.00 14.60 ? 97 LEU A O 1 ATOM 162 C CB . LEU A 1 28 ? 23.357 -38.273 -38.333 1.00 13.48 ? 97 LEU A CB 1 ATOM 163 C CG . LEU A 1 28 ? 23.868 -37.820 -36.952 1.00 12.10 ? 97 LEU A CG 1 ATOM 164 C CD1 . LEU A 1 28 ? 23.750 -36.313 -36.724 1.00 9.95 ? 97 LEU A CD1 1 ATOM 165 C CD2 . LEU A 1 28 ? 23.119 -38.544 -35.893 1.00 11.25 ? 97 LEU A CD2 1 ATOM 166 N N . ILE A 1 29 ? 26.376 -36.973 -39.343 1.00 15.25 ? 98 ILE A N 1 ATOM 167 C CA . ILE A 1 29 ? 27.794 -37.031 -38.949 1.00 14.93 ? 98 ILE A CA 1 ATOM 168 C C . ILE A 1 29 ? 27.918 -36.456 -37.519 1.00 14.70 ? 98 ILE A C 1 ATOM 169 O O . ILE A 1 29 ? 27.905 -35.253 -37.322 1.00 15.74 ? 98 ILE A O 1 ATOM 170 C CB . ILE A 1 29 ? 28.640 -36.243 -39.930 1.00 14.44 ? 98 ILE A CB 1 ATOM 171 C CG1 . ILE A 1 29 ? 28.315 -36.673 -41.362 1.00 15.04 ? 98 ILE A CG1 1 ATOM 172 C CG2 . ILE A 1 29 ? 30.128 -36.465 -39.664 1.00 14.81 ? 98 ILE A CG2 1 ATOM 173 C CD1 . ILE A 1 29 ? 28.897 -38.020 -41.732 1.00 14.93 ? 98 ILE A CD1 1 ATOM 174 N N . SER A 1 30 ? 27.957 -37.316 -36.518 1.00 14.42 ? 99 SER A N 1 ATOM 175 C CA . SER A 1 30 ? 28.013 -36.890 -35.112 1.00 13.92 ? 99 SER A CA 1 ATOM 176 C C . SER A 1 30 ? 29.337 -37.338 -34.501 1.00 13.11 ? 99 SER A C 1 ATOM 177 O O . SER A 1 30 ? 29.421 -38.388 -33.872 1.00 11.61 ? 99 SER A O 1 ATOM 178 C CB . SER A 1 30 ? 26.839 -37.465 -34.329 1.00 13.63 ? 99 SER A CB 1 ATOM 179 O OG . SER A 1 30 ? 26.820 -36.925 -33.021 1.00 14.33 ? 99 SER A OG 1 ATOM 180 N N . PRO A 1 31 ? 30.392 -36.531 -34.689 1.00 13.31 ? 100 PRO A N 1 ATOM 181 C CA . PRO A 1 31 ? 31.706 -37.018 -34.320 1.00 13.84 ? 100 PRO A CA 1 ATOM 182 C C . PRO A 1 31 ? 31.899 -37.167 -32.801 1.00 13.82 ? 100 PRO A C 1 ATOM 183 O O . PRO A 1 31 ? 32.756 -37.945 -32.366 1.00 13.75 ? 100 PRO A O 1 ATOM 184 C CB . PRO A 1 31 ? 32.648 -35.974 -34.926 1.00 14.09 ? 100 PRO A CB 1 ATOM 185 C CG . PRO A 1 31 ? 31.788 -35.161 -35.838 1.00 14.22 ? 100 PRO A CG 1 ATOM 186 C CD . PRO A 1 31 ? 30.469 -35.169 -35.217 1.00 13.32 ? 100 PRO A CD 1 ATOM 187 N N . HIS A 1 32 ? 31.089 -36.475 -32.008 1.00 13.43 ? 101 HIS A N 1 ATOM 188 C CA . HIS A 1 32 ? 31.271 -36.510 -30.558 1.00 13.74 ? 101 HIS A CA 1 ATOM 189 C C . HIS A 1 32 ? 30.587 -37.696 -29.881 1.00 13.65 ? 101 HIS A C 1 ATOM 190 O O . HIS A 1 32 ? 30.747 -37.921 -28.683 1.00 13.57 ? 101 HIS A O 1 ATOM 191 C CB . HIS A 1 32 ? 30.925 -35.134 -29.983 1.00 13.16 ? 101 HIS A CB 1 ATOM 192 C CG . HIS A 1 32 ? 31.775 -34.062 -30.583 1.00 14.01 ? 101 HIS A CG 1 ATOM 193 N ND1 . HIS A 1 32 ? 33.104 -33.915 -30.257 1.00 13.50 ? 101 HIS A ND1 1 ATOM 194 C CD2 . HIS A 1 32 ? 31.533 -33.188 -31.595 1.00 15.59 ? 101 HIS A CD2 1 ATOM 195 C CE1 . HIS A 1 32 ? 33.628 -32.955 -31.003 1.00 15.78 ? 101 HIS A CE1 1 ATOM 196 N NE2 . HIS A 1 32 ? 32.697 -32.499 -31.825 1.00 14.33 ? 101 HIS A NE2 1 ATOM 197 N N . ARG A 1 33 ? 29.899 -38.502 -30.676 1.00 13.83 ? 102 ARG A N 1 ATOM 198 C CA . ARG A 1 33 ? 29.559 -39.880 -30.265 1.00 14.81 ? 102 ARG A CA 1 ATOM 199 C C . ARG A 1 33 ? 30.763 -40.736 -29.790 1.00 14.84 ? 102 ARG A C 1 ATOM 200 O O . ARG A 1 33 ? 30.616 -41.713 -29.031 1.00 14.61 ? 102 ARG A O 1 ATOM 201 C CB . ARG A 1 33 ? 28.851 -40.593 -31.407 1.00 14.76 ? 102 ARG A CB 1 ATOM 202 C CG . ARG A 1 33 ? 27.450 -40.103 -31.610 1.00 16.32 ? 102 ARG A CG 1 ATOM 203 C CD . ARG A 1 33 ? 26.555 -40.523 -30.440 1.00 17.88 ? 102 ARG A CD 1 ATOM 204 N NE . ARG A 1 33 ? 26.235 -41.937 -30.529 1.00 17.05 ? 102 ARG A NE 1 ATOM 205 C CZ . ARG A 1 33 ? 25.429 -42.584 -29.700 1.00 17.48 ? 102 ARG A CZ 1 ATOM 206 N NH1 . ARG A 1 33 ? 24.835 -41.950 -28.682 1.00 18.68 ? 102 ARG A NH1 1 ATOM 207 N NH2 . ARG A 1 33 ? 25.216 -43.876 -29.900 1.00 17.37 ? 102 ARG A NH2 1 ATOM 208 N N . PHE A 1 34 ? 31.946 -40.348 -30.236 1.00 15.18 ? 103 PHE A N 1 ATOM 209 C CA . PHE A 1 34 ? 33.179 -41.038 -29.933 1.00 15.35 ? 103 PHE A CA 1 ATOM 210 C C . PHE A 1 34 ? 34.165 -40.146 -29.149 1.00 15.04 ? 103 PHE A C 1 ATOM 211 O O . PHE A 1 34 ? 35.333 -40.494 -29.000 1.00 14.74 ? 103 PHE A O 1 ATOM 212 C CB . PHE A 1 34 ? 33.809 -41.489 -31.252 1.00 15.69 ? 103 PHE A CB 1 ATOM 213 C CG . PHE A 1 34 ? 32.820 -42.065 -32.227 1.00 16.84 ? 103 PHE A CG 1 ATOM 214 C CD1 . PHE A 1 34 ? 32.175 -43.280 -31.949 1.00 19.49 ? 103 PHE A CD1 1 ATOM 215 C CD2 . PHE A 1 34 ? 32.523 -41.407 -33.408 1.00 16.78 ? 103 PHE A CD2 1 ATOM 216 C CE1 . PHE A 1 34 ? 31.248 -43.834 -32.853 1.00 18.72 ? 103 PHE A CE1 1 ATOM 217 C CE2 . PHE A 1 34 ? 31.595 -41.948 -34.315 1.00 18.22 ? 103 PHE A CE2 1 ATOM 218 C CZ . PHE A 1 34 ? 30.962 -43.173 -34.035 1.00 17.38 ? 103 PHE A CZ 1 ATOM 219 N N . GLY A 1 35 ? 33.702 -39.008 -28.644 1.00 15.21 ? 104 GLY A N 1 ATOM 220 C CA . GLY A 1 35 ? 34.552 -38.124 -27.866 1.00 15.54 ? 104 GLY A CA 1 ATOM 221 C C . GLY A 1 35 ? 34.644 -38.404 -26.350 1.00 16.11 ? 104 GLY A C 1 ATOM 222 O O . GLY A 1 35 ? 35.009 -37.501 -25.607 1.00 16.83 ? 104 GLY A O 1 ATOM 223 N N . GLU A 1 36 ? 34.347 -39.619 -25.883 1.00 16.03 ? 105 GLU A N 1 ATOM 224 C CA . GLU A 1 36 ? 34.307 -39.874 -24.429 1.00 16.92 ? 105 GLU A CA 1 ATOM 225 C C . GLU A 1 36 ? 35.702 -39.978 -23.846 1.00 17.30 ? 105 GLU A C 1 ATOM 226 O O . GLU A 1 36 ? 36.647 -40.413 -24.514 1.00 16.21 ? 105 GLU A O 1 ATOM 227 C CB . GLU A 1 36 ? 33.553 -41.157 -24.030 1.00 15.84 ? 105 GLU A CB 1 ATOM 228 C CG . GLU A 1 36 ? 32.196 -41.334 -24.646 1.00 17.29 ? 105 GLU A CG 1 ATOM 229 C CD . GLU A 1 36 ? 32.252 -42.161 -25.948 1.00 17.48 ? 105 GLU A CD 1 ATOM 230 O OE1 . GLU A 1 36 ? 31.640 -43.257 -25.968 1.00 17.54 ? 105 GLU A OE1 1 ATOM 231 O OE2 . GLU A 1 36 ? 32.956 -41.732 -26.900 1.00 13.00 ? 105 GLU A OE2 1 ATOM 232 N N . THR A 1 37 ? 35.783 -39.571 -22.583 1.00 17.63 ? 106 THR A N 1 ATOM 233 C CA . THR A 1 37 ? 36.942 -39.795 -21.712 1.00 18.03 ? 106 THR A CA 1 ATOM 234 C C . THR A 1 37 ? 37.259 -41.276 -21.638 1.00 17.97 ? 106 THR A C 1 ATOM 235 O O . THR A 1 37 ? 38.423 -41.674 -21.672 1.00 18.45 ? 106 THR A O 1 ATOM 236 C CB . THR A 1 37 ? 36.649 -39.187 -20.294 1.00 17.73 ? 106 THR A CB 1 ATOM 237 O OG1 . THR A 1 37 ? 36.709 -37.758 -20.390 1.00 18.71 ? 106 THR A OG1 1 ATOM 238 C CG2 . THR A 1 37 ? 37.658 -39.629 -19.271 1.00 19.44 ? 106 THR A CG2 1 ATOM 239 N N . LYS A 1 38 ? 36.208 -42.089 -21.560 1.00 18.99 ? 107 LYS A N 1 ATOM 240 C CA A LYS A 1 38 ? 36.447 -43.527 -21.544 0.50 19.27 ? 107 LYS A CA 1 ATOM 241 C CA B LYS A 1 38 ? 36.235 -43.556 -21.605 0.50 19.31 ? 107 LYS A CA 1 ATOM 242 C C . LYS A 1 38 ? 36.646 -44.131 -22.966 1.00 19.42 ? 107 LYS A C 1 ATOM 243 O O . LYS A 1 38 ? 36.927 -45.316 -23.094 1.00 20.25 ? 107 LYS A O 1 ATOM 244 C CB A LYS A 1 38 ? 35.381 -44.244 -20.704 0.50 19.58 ? 107 LYS A CB 1 ATOM 245 C CB B LYS A 1 38 ? 34.821 -44.100 -21.288 0.50 19.54 ? 107 LYS A CB 1 ATOM 246 C CG A LYS A 1 38 ? 35.378 -43.848 -19.187 0.50 19.50 ? 107 LYS A CG 1 ATOM 247 C CG B LYS A 1 38 ? 34.475 -44.208 -19.800 0.50 19.72 ? 107 LYS A CG 1 ATOM 248 C CD A LYS A 1 38 ? 36.758 -43.982 -18.488 0.50 18.85 ? 107 LYS A CD 1 ATOM 249 C CD B LYS A 1 38 ? 33.230 -45.051 -19.562 0.50 19.57 ? 107 LYS A CD 1 ATOM 250 C CE A LYS A 1 38 ? 37.209 -45.442 -18.365 0.50 18.89 ? 107 LYS A CE 1 ATOM 251 C CE B LYS A 1 38 ? 32.050 -44.222 -19.100 0.50 20.25 ? 107 LYS A CE 1 ATOM 252 N NZ A LYS A 1 38 ? 38.682 -45.638 -18.555 0.50 17.61 ? 107 LYS A NZ 1 ATOM 253 N NZ B LYS A 1 38 ? 31.235 -44.969 -18.082 0.50 20.40 ? 107 LYS A NZ 1 ATOM 254 N N . GLY A 1 39 ? 36.611 -43.317 -24.022 1.00 19.93 ? 108 GLY A N 1 ATOM 255 C CA . GLY A 1 39 ? 36.866 -43.807 -25.424 1.00 19.70 ? 108 GLY A CA 1 ATOM 256 C C . GLY A 1 39 ? 38.327 -43.685 -25.863 1.00 20.04 ? 108 GLY A C 1 ATOM 257 O O . GLY A 1 39 ? 39.182 -43.299 -25.077 1.00 19.41 ? 108 GLY A O 1 ATOM 258 N N . ASN A 1 40 ? 38.614 -44.009 -27.132 1.00 20.29 ? 109 ASN A N 1 ATOM 259 C CA . ASN A 1 40 ? 39.966 -43.878 -27.706 1.00 19.89 ? 109 ASN A CA 1 ATOM 260 C C . ASN A 1 40 ? 39.988 -43.083 -29.019 1.00 19.65 ? 109 ASN A C 1 ATOM 261 O O . ASN A 1 40 ? 40.801 -43.361 -29.893 1.00 19.72 ? 109 ASN A O 1 ATOM 262 C CB . ASN A 1 40 ? 40.570 -45.256 -28.022 1.00 20.33 ? 109 ASN A CB 1 ATOM 263 C CG . ASN A 1 40 ? 40.918 -46.056 -26.790 1.00 20.93 ? 109 ASN A CG 1 ATOM 264 O OD1 . ASN A 1 40 ? 41.618 -45.562 -25.900 1.00 22.88 ? 109 ASN A OD1 1 ATOM 265 N ND2 . ASN A 1 40 ? 40.463 -47.322 -26.741 1.00 20.34 ? 109 ASN A ND2 1 ATOM 266 N N . SER A 1 41 ? 39.111 -42.099 -29.174 1.00 18.49 ? 110 SER A N 1 ATOM 267 C CA . SER A 1 41 ? 39.030 -41.386 -30.436 1.00 16.89 ? 110 SER A CA 1 ATOM 268 C C . SER A 1 41 ? 39.405 -39.903 -30.293 1.00 16.32 ? 110 SER A C 1 ATOM 269 O O . SER A 1 41 ? 39.567 -39.393 -29.155 1.00 15.49 ? 110 SER A O 1 ATOM 270 C CB . SER A 1 41 ? 37.631 -41.573 -31.064 1.00 16.89 ? 110 SER A CB 1 ATOM 271 O OG . SER A 1 41 ? 37.368 -42.937 -31.431 1.00 13.90 ? 110 SER A OG 1 ATOM 272 N N . ALA A 1 42 ? 39.551 -39.226 -31.448 1.00 15.05 ? 111 ALA A N 1 ATOM 273 C CA . ALA A 1 42 ? 39.906 -37.794 -31.497 1.00 14.99 ? 111 ALA A CA 1 ATOM 274 C C . ALA A 1 42 ? 39.109 -36.942 -32.513 1.00 14.66 ? 111 ALA A C 1 ATOM 275 O O . ALA A 1 42 ? 39.659 -36.418 -33.459 1.00 13.84 ? 111 ALA A O 1 ATOM 276 C CB . ALA A 1 42 ? 41.425 -37.632 -31.718 1.00 14.82 ? 111 ALA A CB 1 ATOM 277 N N . PRO A 1 43 ? 37.804 -36.761 -32.271 1.00 14.75 ? 112 PRO A N 1 ATOM 278 C CA . PRO A 1 43 ? 37.020 -35.845 -33.055 1.00 14.35 ? 112 PRO A CA 1 ATOM 279 C C . PRO A 1 43 ? 37.444 -34.417 -32.861 1.00 14.37 ? 112 PRO A C 1 ATOM 280 O O . PRO A 1 43 ? 37.726 -33.941 -31.713 1.00 14.04 ? 112 PRO A O 1 ATOM 281 C CB . PRO A 1 43 ? 35.599 -36.043 -32.544 1.00 14.10 ? 112 PRO A CB 1 ATOM 282 C CG . PRO A 1 43 ? 35.731 -36.611 -31.237 1.00 14.58 ? 112 PRO A CG 1 ATOM 283 C CD . PRO A 1 43 ? 36.985 -37.427 -31.252 1.00 15.39 ? 112 PRO A CD 1 ATOM 284 N N . LEU A 1 44 ? 37.478 -33.743 -34.003 1.00 14.26 ? 113 LEU A N 1 ATOM 285 C CA . LEU A 1 44 ? 37.952 -32.377 -34.092 1.00 14.73 ? 113 LEU A CA 1 ATOM 286 C C . LEU A 1 44 ? 36.840 -31.488 -33.602 1.00 14.61 ? 113 LEU A C 1 ATOM 287 O O . LEU A 1 44 ? 35.670 -31.741 -33.894 1.00 14.52 ? 113 LEU A O 1 ATOM 288 C CB . LEU A 1 44 ? 38.335 -32.021 -35.535 1.00 14.65 ? 113 LEU A CB 1 ATOM 289 C CG . LEU A 1 44 ? 39.829 -31.882 -35.864 1.00 16.06 ? 113 LEU A CG 1 ATOM 290 C CD1 . LEU A 1 44 ? 40.661 -32.743 -34.965 1.00 16.08 ? 113 LEU A CD1 1 ATOM 291 C CD2 . LEU A 1 44 ? 40.117 -32.140 -37.357 1.00 13.66 ? 113 LEU A CD2 1 ATOM 292 N N . ILE A 1 45 ? 37.222 -30.457 -32.850 1.00 14.53 ? 114 ILE A N 1 ATOM 293 C CA . ILE A 1 45 ? 36.293 -29.473 -32.324 1.00 14.24 ? 114 ILE A CA 1 ATOM 294 C C . ILE A 1 45 ? 36.076 -28.450 -33.445 1.00 14.66 ? 114 ILE A C 1 ATOM 295 O O . ILE A 1 45 ? 36.999 -27.774 -33.849 1.00 15.63 ? 114 ILE A O 1 ATOM 296 C CB . ILE A 1 45 ? 36.813 -28.863 -30.959 1.00 13.43 ? 114 ILE A CB 1 ATOM 297 C CG1 . ILE A 1 45 ? 36.559 -29.857 -29.809 1.00 13.58 ? 114 ILE A CG1 1 ATOM 298 C CG2 . ILE A 1 45 ? 36.132 -27.583 -30.648 1.00 12.70 ? 114 ILE A CG2 1 ATOM 299 C CD1 . ILE A 1 45 ? 37.161 -29.460 -28.400 1.00 10.47 ? 114 ILE A CD1 1 ATOM 300 N N . ILE A 1 46 ? 34.848 -28.391 -33.965 1.00 15.59 ? 115 ILE A N 1 ATOM 301 C CA . ILE A 1 46 ? 34.477 -27.553 -35.113 1.00 15.39 ? 115 ILE A CA 1 ATOM 302 C C . ILE A 1 46 ? 33.233 -26.692 -34.832 1.00 15.69 ? 115 ILE A C 1 ATOM 303 O O . ILE A 1 46 ? 32.556 -26.822 -33.783 1.00 16.08 ? 115 ILE A O 1 ATOM 304 C CB . ILE A 1 46 ? 34.240 -28.404 -36.439 1.00 15.67 ? 115 ILE A CB 1 ATOM 305 C CG1 . ILE A 1 46 ? 33.285 -29.583 -36.211 1.00 16.55 ? 115 ILE A CG1 1 ATOM 306 C CG2 . ILE A 1 46 ? 35.563 -28.912 -37.017 1.00 15.33 ? 115 ILE A CG2 1 ATOM 307 C CD1 . ILE A 1 46 ? 31.837 -29.219 -36.252 1.00 19.21 ? 115 ILE A CD1 1 ATOM 308 N N . ARG A 1 47 ? 32.986 -25.770 -35.752 1.00 14.74 ? 116 ARG A N 1 ATOM 309 C CA . ARG A 1 47 ? 31.694 -25.137 -35.916 1.00 14.46 ? 116 ARG A CA 1 ATOM 310 C C . ARG A 1 47 ? 31.608 -24.663 -37.379 1.00 13.87 ? 116 ARG A C 1 ATOM 311 O O . ARG A 1 47 ? 32.521 -24.889 -38.157 1.00 13.91 ? 116 ARG A O 1 ATOM 312 C CB . ARG A 1 47 ? 31.482 -23.998 -34.889 1.00 14.27 ? 116 ARG A CB 1 ATOM 313 C CG . ARG A 1 47 ? 30.570 -24.388 -33.723 1.00 13.19 ? 116 ARG A CG 1 ATOM 314 C CD . ARG A 1 47 ? 29.731 -23.217 -33.238 1.00 14.75 ? 116 ARG A CD 1 ATOM 315 N NE . ARG A 1 47 ? 28.697 -22.836 -34.213 1.00 14.98 ? 116 ARG A NE 1 ATOM 316 C CZ . ARG A 1 47 ? 28.256 -21.589 -34.426 1.00 16.07 ? 116 ARG A CZ 1 ATOM 317 N NH1 . ARG A 1 47 ? 28.755 -20.553 -33.749 1.00 14.94 ? 116 ARG A NH1 1 ATOM 318 N NH2 . ARG A 1 47 ? 27.309 -21.362 -35.334 1.00 15.66 ? 116 ARG A NH2 1 ATOM 319 N N . GLU A 1 48 ? 30.498 -24.079 -37.756 1.00 13.51 ? 117 GLU A N 1 ATOM 320 C CA . GLU A 1 48 ? 30.248 -23.695 -39.169 1.00 14.28 ? 117 GLU A CA 1 ATOM 321 C C . GLU A 1 48 ? 30.639 -24.799 -40.193 1.00 13.73 ? 117 GLU A C 1 ATOM 322 O O . GLU A 1 48 ? 31.510 -24.588 -41.052 1.00 13.49 ? 117 GLU A O 1 ATOM 323 C CB . GLU A 1 48 ? 30.931 -22.358 -39.513 1.00 14.22 ? 117 GLU A CB 1 ATOM 324 C CG . GLU A 1 48 ? 30.578 -21.173 -38.588 1.00 17.03 ? 117 GLU A CG 1 ATOM 325 C CD . GLU A 1 48 ? 31.431 -21.145 -37.318 1.00 20.94 ? 117 GLU A CD 1 ATOM 326 O OE1 . GLU A 1 48 ? 32.629 -21.479 -37.383 1.00 24.75 ? 117 GLU A OE1 1 ATOM 327 O OE2 . GLU A 1 48 ? 30.904 -20.823 -36.238 1.00 23.56 ? 117 GLU A OE2 1 ATOM 328 N N . PRO A 1 49 ? 30.002 -25.989 -40.078 1.00 13.29 ? 118 PRO A N 1 ATOM 329 C CA . PRO A 1 49 ? 30.165 -27.036 -41.068 1.00 13.09 ? 118 PRO A CA 1 ATOM 330 C C . PRO A 1 49 ? 29.378 -26.728 -42.331 1.00 13.14 ? 118 PRO A C 1 ATOM 331 O O . PRO A 1 49 ? 28.419 -25.998 -42.277 1.00 12.07 ? 118 PRO A O 1 ATOM 332 C CB . PRO A 1 49 ? 29.568 -28.247 -40.390 1.00 13.00 ? 118 PRO A CB 1 ATOM 333 C CG . PRO A 1 49 ? 28.512 -27.657 -39.497 1.00 13.23 ? 118 PRO A CG 1 ATOM 334 C CD . PRO A 1 49 ? 29.084 -26.394 -39.004 1.00 12.72 ? 118 PRO A CD 1 ATOM 335 N N . PHE A 1 50 ? 29.805 -27.290 -43.454 1.00 13.29 ? 119 PHE A N 1 ATOM 336 C CA . PHE A 1 50 ? 29.076 -27.160 -44.701 1.00 13.87 ? 119 PHE A CA 1 ATOM 337 C C . PHE A 1 50 ? 29.555 -28.227 -45.669 1.00 14.18 ? 119 PHE A C 1 ATOM 338 O O . PHE A 1 50 ? 30.546 -28.908 -45.400 1.00 15.40 ? 119 PHE A O 1 ATOM 339 C CB . PHE A 1 50 ? 29.161 -25.734 -45.269 1.00 13.44 ? 119 PHE A CB 1 ATOM 340 C CG . PHE A 1 50 ? 30.498 -25.361 -45.902 1.00 13.70 ? 119 PHE A CG 1 ATOM 341 C CD1 . PHE A 1 50 ? 30.702 -25.537 -47.289 1.00 13.44 ? 119 PHE A CD1 1 ATOM 342 C CD2 . PHE A 1 50 ? 31.488 -24.730 -45.158 1.00 12.56 ? 119 PHE A CD2 1 ATOM 343 C CE1 . PHE A 1 50 ? 31.907 -25.171 -47.903 1.00 10.99 ? 119 PHE A CE1 1 ATOM 344 C CE2 . PHE A 1 50 ? 32.680 -24.337 -45.756 1.00 14.71 ? 119 PHE A CE2 1 ATOM 345 C CZ . PHE A 1 50 ? 32.897 -24.562 -47.145 1.00 13.44 ? 119 PHE A CZ 1 ATOM 346 N N . ILE A 1 51 ? 28.816 -28.436 -46.747 1.00 14.45 ? 120 ILE A N 1 ATOM 347 C CA . ILE A 1 51 ? 29.128 -29.503 -47.695 1.00 14.88 ? 120 ILE A CA 1 ATOM 348 C C . ILE A 1 51 ? 29.149 -28.922 -49.116 1.00 15.83 ? 120 ILE A C 1 ATOM 349 O O . ILE A 1 51 ? 28.430 -27.960 -49.431 1.00 15.14 ? 120 ILE A O 1 ATOM 350 C CB . ILE A 1 51 ? 28.145 -30.711 -47.559 1.00 14.60 ? 120 ILE A CB 1 ATOM 351 C CG1 . ILE A 1 51 ? 28.283 -31.350 -46.159 1.00 16.34 ? 120 ILE A CG1 1 ATOM 352 C CG2 . ILE A 1 51 ? 28.414 -31.780 -48.640 1.00 12.92 ? 120 ILE A CG2 1 ATOM 353 C CD1 . ILE A 1 51 ? 27.038 -31.982 -45.624 1.00 15.62 ? 120 ILE A CD1 1 ATOM 354 N N . ALA A 1 52 ? 30.016 -29.489 -49.951 1.00 16.58 ? 121 ALA A N 1 ATOM 355 C CA . ALA A 1 52 ? 30.137 -29.073 -51.341 1.00 17.37 ? 121 ALA A CA 1 ATOM 356 C C . ALA A 1 52 ? 30.537 -30.305 -52.113 1.00 18.05 ? 121 ALA A C 1 ATOM 357 O O . ALA A 1 52 ? 31.330 -31.140 -51.629 1.00 18.11 ? 121 ALA A O 1 ATOM 358 C CB . ALA A 1 52 ? 31.173 -27.976 -51.488 1.00 17.37 ? 121 ALA A CB 1 ATOM 359 N N . CYS A 1 53 ? 29.962 -30.434 -53.294 1.00 18.29 ? 122 CYS A N 1 ATOM 360 C CA . CYS A 1 53 ? 30.087 -31.636 -54.088 1.00 19.38 ? 122 CYS A CA 1 ATOM 361 C C . CYS A 1 53 ? 30.683 -31.319 -55.451 1.00 19.76 ? 122 CYS A C 1 ATOM 362 O O . CYS A 1 53 ? 30.382 -30.300 -56.042 1.00 17.86 ? 122 CYS A O 1 ATOM 363 C CB . CYS A 1 53 ? 28.712 -32.286 -54.246 1.00 19.44 ? 122 CYS A CB 1 ATOM 364 S SG . CYS A 1 53 ? 28.008 -32.894 -52.644 1.00 23.15 ? 122 CYS A SG 1 ATOM 365 N N . GLY A 1 54 ? 31.556 -32.204 -55.917 1.00 21.42 ? 123 GLY A N 1 ATOM 366 C CA . GLY A 1 54 ? 32.063 -32.154 -57.286 1.00 23.01 ? 123 GLY A CA 1 ATOM 367 C C . GLY A 1 54 ? 31.549 -33.315 -58.115 1.00 23.80 ? 123 GLY A C 1 ATOM 368 O O . GLY A 1 54 ? 30.783 -34.132 -57.620 1.00 23.86 ? 123 GLY A O 1 ATOM 369 N N . PRO A 1 55 ? 31.990 -33.412 -59.384 1.00 25.61 ? 124 PRO A N 1 ATOM 370 C CA . PRO A 1 55 ? 31.489 -34.469 -60.276 1.00 26.30 ? 124 PRO A CA 1 ATOM 371 C C . PRO A 1 55 ? 31.681 -35.902 -59.739 1.00 27.30 ? 124 PRO A C 1 ATOM 372 O O . PRO A 1 55 ? 30.855 -36.771 -60.029 1.00 27.57 ? 124 PRO A O 1 ATOM 373 C CB . PRO A 1 55 ? 32.261 -34.237 -61.583 1.00 26.87 ? 124 PRO A CB 1 ATOM 374 C CG . PRO A 1 55 ? 33.436 -33.356 -61.212 1.00 26.73 ? 124 PRO A CG 1 ATOM 375 C CD . PRO A 1 55 ? 32.976 -32.539 -60.044 1.00 25.80 ? 124 PRO A CD 1 ATOM 376 N N . LYS A 1 56 ? 32.708 -36.140 -58.921 1.00 28.13 ? 125 LYS A N 1 ATOM 377 C CA . LYS A 1 56 ? 32.950 -37.475 -58.379 1.00 28.75 ? 125 LYS A CA 1 ATOM 378 C C . LYS A 1 56 ? 32.762 -37.639 -56.845 1.00 28.69 ? 125 LYS A C 1 ATOM 379 O O . LYS A 1 56 ? 32.475 -38.741 -56.382 1.00 28.45 ? 125 LYS A O 1 ATOM 380 C CB . LYS A 1 56 ? 34.335 -37.978 -58.825 1.00 29.22 ? 125 LYS A CB 1 ATOM 381 C CG . LYS A 1 56 ? 35.533 -37.525 -57.985 1.00 31.34 ? 125 LYS A CG 1 ATOM 382 C CD . LYS A 1 56 ? 36.777 -38.447 -58.191 1.00 33.18 ? 125 LYS A CD 1 ATOM 383 C CE . LYS A 1 56 ? 36.938 -39.467 -57.056 1.00 33.55 ? 125 LYS A CE 1 ATOM 384 N NZ . LYS A 1 56 ? 37.899 -40.553 -57.400 1.00 34.91 ? 125 LYS A NZ 1 ATOM 385 N N . GLU A 1 57 ? 32.892 -36.566 -56.065 1.00 28.39 ? 126 GLU A N 1 ATOM 386 C CA . GLU A 1 57 ? 32.956 -36.696 -54.597 1.00 28.43 ? 126 GLU A CA 1 ATOM 387 C C . GLU A 1 57 ? 32.266 -35.527 -53.920 1.00 26.93 ? 126 GLU A C 1 ATOM 388 O O . GLU A 1 57 ? 32.142 -34.454 -54.503 1.00 26.61 ? 126 GLU A O 1 ATOM 389 C CB . GLU A 1 57 ? 34.436 -36.748 -54.150 1.00 29.18 ? 126 GLU A CB 1 ATOM 390 C CG . GLU A 1 57 ? 34.678 -36.756 -52.609 1.00 32.27 ? 126 GLU A CG 1 ATOM 391 C CD . GLU A 1 57 ? 36.150 -36.543 -52.192 1.00 34.30 ? 126 GLU A CD 1 ATOM 392 O OE1 . GLU A 1 57 ? 37.034 -36.528 -53.086 1.00 36.87 ? 126 GLU A OE1 1 ATOM 393 O OE2 . GLU A 1 57 ? 36.406 -36.364 -50.968 1.00 33.87 ? 126 GLU A OE2 1 ATOM 394 N N . CYS A 1 58 ? 31.806 -35.754 -52.692 1.00 25.32 ? 127 CYS A N 1 ATOM 395 C CA . CYS A 1 58 ? 31.344 -34.680 -51.834 1.00 24.04 ? 127 CYS A CA 1 ATOM 396 C C . CYS A 1 58 ? 32.316 -34.529 -50.673 1.00 22.50 ? 127 CYS A C 1 ATOM 397 O O . CYS A 1 58 ? 32.711 -35.521 -50.060 1.00 23.15 ? 127 CYS A O 1 ATOM 398 C CB . CYS A 1 58 ? 29.922 -34.940 -51.316 1.00 24.35 ? 127 CYS A CB 1 ATOM 399 S SG . CYS A 1 58 ? 28.615 -34.861 -52.574 1.00 25.23 ? 127 CYS A SG 1 ATOM 400 N N . LYS A 1 59 ? 32.709 -33.283 -50.400 1.00 21.00 ? 128 LYS A N 1 ATOM 401 C CA . LYS A 1 59 ? 33.510 -32.924 -49.225 1.00 19.81 ? 128 LYS A CA 1 ATOM 402 C C . LYS A 1 59 ? 32.686 -32.247 -48.119 1.00 18.58 ? 128 LYS A C 1 ATOM 403 O O . LYS A 1 59 ? 31.914 -31.344 -48.394 1.00 17.60 ? 128 LYS A O 1 ATOM 404 C CB . LYS A 1 59 ? 34.668 -32.017 -49.647 1.00 19.91 ? 128 LYS A CB 1 ATOM 405 C CG . LYS A 1 59 ? 35.862 -32.808 -50.156 1.00 20.61 ? 128 LYS A CG 1 ATOM 406 C CD . LYS A 1 59 ? 36.970 -31.948 -50.690 1.00 21.10 ? 128 LYS A CD 1 ATOM 407 C CE . LYS A 1 59 ? 37.957 -32.835 -51.376 1.00 22.68 ? 128 LYS A CE 1 ATOM 408 N NZ . LYS A 1 59 ? 39.291 -32.245 -51.348 1.00 26.93 ? 128 LYS A NZ 1 ATOM 409 N N . HIS A 1 60 ? 32.882 -32.700 -46.877 1.00 17.99 ? 129 HIS A N 1 ATOM 410 C CA . HIS A 1 60 ? 32.308 -32.107 -45.655 1.00 16.99 ? 129 HIS A CA 1 ATOM 411 C C . HIS A 1 60 ? 33.335 -31.186 -44.976 1.00 16.94 ? 129 HIS A C 1 ATOM 412 O O . HIS A 1 60 ? 34.325 -31.664 -44.405 1.00 17.25 ? 129 HIS A O 1 ATOM 413 C CB . HIS A 1 60 ? 31.886 -33.248 -44.719 1.00 17.56 ? 129 HIS A CB 1 ATOM 414 C CG . HIS A 1 60 ? 31.335 -32.819 -43.393 1.00 15.53 ? 129 HIS A CG 1 ATOM 415 N ND1 . HIS A 1 60 ? 31.244 -33.685 -42.326 1.00 16.58 ? 129 HIS A ND1 1 ATOM 416 C CD2 . HIS A 1 60 ? 30.820 -31.645 -42.965 1.00 15.82 ? 129 HIS A CD2 1 ATOM 417 C CE1 . HIS A 1 60 ? 30.716 -33.059 -41.291 1.00 16.69 ? 129 HIS A CE1 1 ATOM 418 N NE2 . HIS A 1 60 ? 30.444 -31.819 -41.652 1.00 17.64 ? 129 HIS A NE2 1 ATOM 419 N N . PHE A 1 61 ? 33.104 -29.868 -45.052 1.00 16.12 ? 130 PHE A N 1 ATOM 420 C CA . PHE A 1 61 ? 34.045 -28.853 -44.544 1.00 15.30 ? 130 PHE A CA 1 ATOM 421 C C . PHE A 1 61 ? 33.621 -28.322 -43.187 1.00 14.80 ? 130 PHE A C 1 ATOM 422 O O . PHE A 1 61 ? 32.456 -28.426 -42.808 1.00 14.79 ? 130 PHE A O 1 ATOM 423 C CB . PHE A 1 61 ? 34.097 -27.664 -45.489 1.00 15.19 ? 130 PHE A CB 1 ATOM 424 C CG . PHE A 1 61 ? 34.618 -27.972 -46.839 1.00 12.73 ? 130 PHE A CG 1 ATOM 425 C CD1 . PHE A 1 61 ? 35.950 -27.740 -47.141 1.00 12.31 ? 130 PHE A CD1 1 ATOM 426 C CD2 . PHE A 1 61 ? 33.775 -28.453 -47.831 1.00 13.78 ? 130 PHE A CD2 1 ATOM 427 C CE1 . PHE A 1 61 ? 36.441 -27.997 -48.400 1.00 13.84 ? 130 PHE A CE1 1 ATOM 428 C CE2 . PHE A 1 61 ? 34.243 -28.707 -49.116 1.00 12.04 ? 130 PHE A CE2 1 ATOM 429 C CZ . PHE A 1 61 ? 35.575 -28.485 -49.412 1.00 13.35 ? 130 PHE A CZ 1 ATOM 430 N N . ALA A 1 62 ? 34.554 -27.723 -42.468 1.00 14.50 ? 131 ALA A N 1 ATOM 431 C CA . ALA A 1 62 ? 34.251 -27.092 -41.169 1.00 14.48 ? 131 ALA A CA 1 ATOM 432 C C . ALA A 1 62 ? 35.390 -26.161 -40.739 1.00 14.83 ? 131 ALA A C 1 ATOM 433 O O . ALA A 1 62 ? 36.476 -26.145 -41.350 1.00 15.49 ? 131 ALA A O 1 ATOM 434 C CB . ALA A 1 62 ? 33.942 -28.172 -40.067 1.00 13.87 ? 131 ALA A CB 1 ATOM 435 N N . LEU A 1 63 ? 35.159 -25.348 -39.713 1.00 14.35 ? 132 LEU A N 1 ATOM 436 C CA . LEU A 1 63 ? 36.230 -24.539 -39.177 1.00 13.98 ? 132 LEU A CA 1 ATOM 437 C C . LEU A 1 63 ? 36.563 -25.145 -37.814 1.00 14.28 ? 132 LEU A C 1 ATOM 438 O O . LEU A 1 63 ? 35.737 -25.118 -36.904 1.00 13.83 ? 132 LEU A O 1 ATOM 439 C CB . LEU A 1 63 ? 35.820 -23.078 -39.046 1.00 14.00 ? 132 LEU A CB 1 ATOM 440 C CG . LEU A 1 63 ? 35.378 -22.341 -40.322 1.00 15.50 ? 132 LEU A CG 1 ATOM 441 C CD1 . LEU A 1 63 ? 34.803 -20.984 -39.947 1.00 15.26 ? 132 LEU A CD1 1 ATOM 442 C CD2 . LEU A 1 63 ? 36.543 -22.163 -41.296 1.00 13.42 ? 132 LEU A CD2 1 ATOM 443 N N . THR A 1 64 ? 37.776 -25.675 -37.688 1.00 14.21 ? 133 THR A N 1 ATOM 444 C CA . THR A 1 64 ? 38.219 -26.273 -36.456 1.00 14.80 ? 133 THR A CA 1 ATOM 445 C C . THR A 1 64 ? 38.901 -25.270 -35.554 1.00 15.31 ? 133 THR A C 1 ATOM 446 O O . THR A 1 64 ? 39.495 -24.306 -36.034 1.00 14.92 ? 133 THR A O 1 ATOM 447 C CB . THR A 1 64 ? 39.185 -27.460 -36.711 1.00 15.01 ? 133 THR A CB 1 ATOM 448 O OG1 . THR A 1 64 ? 39.364 -28.150 -35.476 1.00 14.76 ? 133 THR A OG1 1 ATOM 449 C CG2 . THR A 1 64 ? 40.522 -27.010 -37.246 1.00 11.69 ? 133 THR A CG2 1 ATOM 450 N N . HIS A 1 65 ? 38.807 -25.518 -34.249 1.00 16.10 ? 134 HIS A N 1 ATOM 451 C CA . HIS A 1 65 ? 39.617 -24.801 -33.259 1.00 16.40 ? 134 HIS A CA 1 ATOM 452 C C . HIS A 1 65 ? 41.015 -25.433 -33.030 1.00 16.40 ? 134 HIS A C 1 ATOM 453 O O . HIS A 1 65 ? 41.760 -24.980 -32.162 1.00 16.96 ? 134 HIS A O 1 ATOM 454 C CB . HIS A 1 65 ? 38.857 -24.639 -31.924 1.00 16.76 ? 134 HIS A CB 1 ATOM 455 C CG . HIS A 1 65 ? 37.944 -23.445 -31.888 1.00 17.72 ? 134 HIS A CG 1 ATOM 456 N ND1 . HIS A 1 65 ? 38.410 -22.149 -31.931 1.00 16.63 ? 134 HIS A ND1 1 ATOM 457 C CD2 . HIS A 1 65 ? 36.593 -23.356 -31.805 1.00 19.53 ? 134 HIS A CD2 1 ATOM 458 C CE1 . HIS A 1 65 ? 37.387 -21.316 -31.877 1.00 18.78 ? 134 HIS A CE1 1 ATOM 459 N NE2 . HIS A 1 65 ? 36.272 -22.024 -31.807 1.00 16.96 ? 134 HIS A NE2 1 ATOM 460 N N . TYR A 1 66 ? 41.391 -26.449 -33.811 1.00 16.23 ? 135 TYR A N 1 ATOM 461 C CA . TYR A 1 66 ? 42.706 -27.076 -33.661 1.00 16.48 ? 135 TYR A CA 1 ATOM 462 C C . TYR A 1 66 ? 42.836 -27.766 -32.277 1.00 16.83 ? 135 TYR A C 1 ATOM 463 O O . TYR A 1 66 ? 43.896 -27.725 -31.635 1.00 16.30 ? 135 TYR A O 1 ATOM 464 C CB . TYR A 1 66 ? 43.849 -26.036 -33.873 1.00 16.68 ? 135 TYR A CB 1 ATOM 465 C CG . TYR A 1 66 ? 44.889 -26.500 -34.853 1.00 15.73 ? 135 TYR A CG 1 ATOM 466 C CD1 . TYR A 1 66 ? 45.709 -27.574 -34.565 1.00 16.07 ? 135 TYR A CD1 1 ATOM 467 C CD2 . TYR A 1 66 ? 45.012 -25.896 -36.098 1.00 15.01 ? 135 TYR A CD2 1 ATOM 468 C CE1 . TYR A 1 66 ? 46.641 -28.017 -35.485 1.00 15.98 ? 135 TYR A CE1 1 ATOM 469 C CE2 . TYR A 1 66 ? 45.924 -26.329 -37.008 1.00 13.40 ? 135 TYR A CE2 1 ATOM 470 C CZ . TYR A 1 66 ? 46.733 -27.385 -36.708 1.00 15.39 ? 135 TYR A CZ 1 ATOM 471 O OH . TYR A 1 66 ? 47.633 -27.827 -37.645 1.00 16.01 ? 135 TYR A OH 1 ATOM 472 N N . ALA A 1 67 ? 41.747 -28.405 -31.863 1.00 16.76 ? 136 ALA A N 1 ATOM 473 C CA . ALA A 1 67 ? 41.639 -29.083 -30.597 1.00 17.13 ? 136 ALA A CA 1 ATOM 474 C C . ALA A 1 67 ? 40.714 -30.271 -30.787 1.00 17.13 ? 136 ALA A C 1 ATOM 475 O O . ALA A 1 67 ? 39.831 -30.234 -31.623 1.00 18.39 ? 136 ALA A O 1 ATOM 476 C CB . ALA A 1 67 ? 41.102 -28.138 -29.526 1.00 17.04 ? 136 ALA A CB 1 ATOM 477 N N . ALA A 1 68 ? 40.922 -31.320 -30.003 1.00 17.17 ? 137 ALA A N 1 ATOM 478 C CA . ALA A 1 68 ? 40.116 -32.524 -30.053 1.00 16.81 ? 137 ALA A CA 1 ATOM 479 C C . ALA A 1 68 ? 39.396 -32.698 -28.733 1.00 16.58 ? 137 ALA A C 1 ATOM 480 O O . ALA A 1 68 ? 39.813 -32.127 -27.726 1.00 17.22 ? 137 ALA A O 1 ATOM 481 C CB . ALA A 1 68 ? 41.013 -33.748 -30.290 1.00 16.91 ? 137 ALA A CB 1 ATOM 482 N N . GLN A 1 69 ? 38.329 -33.497 -28.766 1.00 16.72 ? 138 GLN A N 1 ATOM 483 C CA . GLN A 1 69 ? 37.710 -34.062 -27.588 1.00 17.20 ? 138 GLN A CA 1 ATOM 484 C C . GLN A 1 69 ? 37.900 -35.575 -27.579 1.00 17.28 ? 138 GLN A C 1 ATOM 485 O O . GLN A 1 69 ? 37.572 -36.232 -28.551 1.00 17.59 ? 138 GLN A O 1 ATOM 486 C CB . GLN A 1 69 ? 36.211 -33.760 -27.553 1.00 17.73 ? 138 GLN A CB 1 ATOM 487 C CG . GLN A 1 69 ? 35.541 -34.204 -26.243 1.00 17.48 ? 138 GLN A CG 1 ATOM 488 C CD . GLN A 1 69 ? 34.104 -34.603 -26.400 1.00 19.68 ? 138 GLN A CD 1 ATOM 489 O OE1 . GLN A 1 69 ? 33.627 -34.823 -27.520 1.00 18.24 ? 138 GLN A OE1 1 ATOM 490 N NE2 . GLN A 1 69 ? 33.383 -34.700 -25.260 1.00 18.18 ? 138 GLN A NE2 1 ATOM 491 N N . PRO A 1 70 ? 38.390 -36.142 -26.460 1.00 17.93 ? 139 PRO A N 1 ATOM 492 C CA . PRO A 1 70 ? 38.790 -35.490 -25.195 1.00 17.95 ? 139 PRO A CA 1 ATOM 493 C C . PRO A 1 70 ? 40.119 -34.716 -25.332 1.00 17.81 ? 139 PRO A C 1 ATOM 494 O O . PRO A 1 70 ? 40.858 -34.942 -26.296 1.00 18.43 ? 139 PRO A O 1 ATOM 495 C CB . PRO A 1 70 ? 38.911 -36.671 -24.240 1.00 17.99 ? 139 PRO A CB 1 ATOM 496 C CG . PRO A 1 70 ? 39.301 -37.820 -25.140 1.00 17.50 ? 139 PRO A CG 1 ATOM 497 C CD . PRO A 1 70 ? 38.479 -37.611 -26.358 1.00 17.82 ? 139 PRO A CD 1 ATOM 498 N N . GLY A 1 71 ? 40.383 -33.769 -24.433 1.00 17.63 ? 140 GLY A N 1 ATOM 499 C CA . GLY A 1 71 ? 41.599 -32.951 -24.505 1.00 17.57 ? 140 GLY A CA 1 ATOM 500 C C . GLY A 1 71 ? 41.652 -31.731 -23.593 1.00 18.20 ? 140 GLY A C 1 ATOM 501 O O . GLY A 1 71 ? 40.744 -31.483 -22.804 1.00 18.66 ? 140 GLY A O 1 ATOM 502 N N . GLY A 1 72 ? 42.718 -30.946 -23.726 1.00 18.52 ? 141 GLY A N 1 ATOM 503 C CA . GLY A 1 72 ? 43.014 -29.884 -22.781 1.00 18.48 ? 141 GLY A CA 1 ATOM 504 C C . GLY A 1 72 ? 42.905 -28.469 -23.298 1.00 18.95 ? 141 GLY A C 1 ATOM 505 O O . GLY A 1 72 ? 43.268 -27.537 -22.566 1.00 18.65 ? 141 GLY A O 1 ATOM 506 N N . TYR A 1 73 ? 42.397 -28.296 -24.530 1.00 18.52 ? 142 TYR A N 1 ATOM 507 C CA . TYR A 1 73 ? 42.317 -26.969 -25.148 1.00 18.78 ? 142 TYR A CA 1 ATOM 508 C C . TYR A 1 73 ? 40.875 -26.495 -25.332 1.00 18.17 ? 142 TYR A C 1 ATOM 509 O O . TYR A 1 73 ? 40.568 -25.817 -26.300 1.00 17.68 ? 142 TYR A O 1 ATOM 510 C CB . TYR A 1 73 ? 43.097 -26.908 -26.474 1.00 19.05 ? 142 TYR A CB 1 ATOM 511 C CG . TYR A 1 73 ? 44.574 -27.155 -26.268 1.00 20.10 ? 142 TYR A CG 1 ATOM 512 C CD1 . TYR A 1 73 ? 45.371 -26.227 -25.602 1.00 19.69 ? 142 TYR A CD1 1 ATOM 513 C CD2 . TYR A 1 73 ? 45.166 -28.332 -26.705 1.00 19.61 ? 142 TYR A CD2 1 ATOM 514 C CE1 . TYR A 1 73 ? 46.721 -26.469 -25.382 1.00 18.03 ? 142 TYR A CE1 1 ATOM 515 C CE2 . TYR A 1 73 ? 46.513 -28.574 -26.488 1.00 20.23 ? 142 TYR A CE2 1 ATOM 516 C CZ . TYR A 1 73 ? 47.280 -27.640 -25.830 1.00 17.49 ? 142 TYR A CZ 1 ATOM 517 O OH . TYR A 1 73 ? 48.608 -27.914 -25.617 1.00 18.07 ? 142 TYR A OH 1 ATOM 518 N N . TYR A 1 74 ? 40.015 -26.808 -24.355 1.00 17.68 ? 143 TYR A N 1 ATOM 519 C CA . TYR A 1 74 ? 38.592 -26.447 -24.442 1.00 17.46 ? 143 TYR A CA 1 ATOM 520 C C . TYR A 1 74 ? 38.387 -24.961 -24.333 1.00 17.21 ? 143 TYR A C 1 ATOM 521 O O . TYR A 1 74 ? 37.421 -24.437 -24.870 1.00 16.80 ? 143 TYR A O 1 ATOM 522 C CB . TYR A 1 74 ? 37.743 -27.143 -23.363 1.00 16.78 ? 143 TYR A CB 1 ATOM 523 C CG . TYR A 1 74 ? 37.638 -28.658 -23.498 1.00 17.14 ? 143 TYR A CG 1 ATOM 524 C CD1 . TYR A 1 74 ? 37.971 -29.333 -24.704 1.00 13.85 ? 143 TYR A CD1 1 ATOM 525 C CD2 . TYR A 1 74 ? 37.192 -29.424 -22.417 1.00 15.18 ? 143 TYR A CD2 1 ATOM 526 C CE1 . TYR A 1 74 ? 37.870 -30.723 -24.794 1.00 14.41 ? 143 TYR A CE1 1 ATOM 527 C CE2 . TYR A 1 74 ? 37.089 -30.796 -22.494 1.00 15.21 ? 143 TYR A CE2 1 ATOM 528 C CZ . TYR A 1 74 ? 37.420 -31.458 -23.675 1.00 16.26 ? 143 TYR A CZ 1 ATOM 529 O OH . TYR A 1 74 ? 37.290 -32.849 -23.715 1.00 15.43 ? 143 TYR A OH 1 ATOM 530 N N . ASN A 1 75 ? 39.289 -24.285 -23.627 1.00 17.34 ? 144 ASN A N 1 ATOM 531 C CA . ASN A 1 75 ? 39.134 -22.868 -23.395 1.00 17.42 ? 144 ASN A CA 1 ATOM 532 C C . ASN A 1 75 ? 39.325 -22.083 -24.704 1.00 17.61 ? 144 ASN A C 1 ATOM 533 O O . ASN A 1 75 ? 40.316 -22.330 -25.410 1.00 17.24 ? 144 ASN A O 1 ATOM 534 C CB . ASN A 1 75 ? 40.142 -22.402 -22.354 1.00 17.82 ? 144 ASN A CB 1 ATOM 535 C CG . ASN A 1 75 ? 39.860 -21.016 -21.889 1.00 18.90 ? 144 ASN A CG 1 ATOM 536 O OD1 . ASN A 1 75 ? 38.707 -20.616 -21.861 1.00 20.89 ? 144 ASN A OD1 1 ATOM 537 N ND2 . ASN A 1 75 ? 40.899 -20.258 -21.530 1.00 22.47 ? 144 ASN A ND2 1 ATOM 538 N N . GLY A 1 76 ? 38.383 -21.164 -24.998 1.00 17.42 ? 145 GLY A N 1 ATOM 539 C CA . GLY A 1 76 ? 38.400 -20.308 -26.199 1.00 17.89 ? 145 GLY A CA 1 ATOM 540 C C . GLY A 1 76 ? 37.701 -20.953 -27.391 1.00 18.28 ? 145 GLY A C 1 ATOM 541 O O . GLY A 1 76 ? 37.619 -20.408 -28.481 1.00 18.14 ? 145 GLY A O 1 ATOM 542 N N . THR A 1 77 ? 37.143 -22.118 -27.138 1.00 18.76 ? 146 THR A N 1 ATOM 543 C CA . THR A 1 77 ? 36.555 -22.958 -28.153 1.00 19.10 ? 146 THR A CA 1 ATOM 544 C C . THR A 1 77 ? 35.100 -22.525 -28.408 1.00 19.68 ? 146 THR A C 1 ATOM 545 O O . THR A 1 77 ? 34.420 -23.053 -29.286 1.00 19.02 ? 146 THR A O 1 ATOM 546 C CB . THR A 1 77 ? 36.688 -24.410 -27.660 1.00 19.32 ? 146 THR A CB 1 ATOM 547 O OG1 . THR A 1 77 ? 37.432 -25.196 -28.596 1.00 22.25 ? 146 THR A OG1 1 ATOM 548 C CG2 . THR A 1 77 ? 35.377 -25.009 -27.278 1.00 17.46 ? 146 THR A CG2 1 ATOM 549 N N . ARG A 1 78 ? 34.634 -21.546 -27.635 1.00 20.23 ? 147 ARG A N 1 ATOM 550 C CA . ARG A 1 78 ? 33.370 -20.872 -27.913 1.00 20.85 ? 147 ARG A CA 1 ATOM 551 C C . ARG A 1 78 ? 33.486 -19.543 -28.677 1.00 20.70 ? 147 ARG A C 1 ATOM 552 O O . ARG A 1 78 ? 32.478 -18.995 -29.072 1.00 21.29 ? 147 ARG A O 1 ATOM 553 C CB . ARG A 1 78 ? 32.584 -20.638 -26.620 1.00 20.82 ? 147 ARG A CB 1 ATOM 554 C CG . ARG A 1 78 ? 31.292 -21.403 -26.587 1.00 22.36 ? 147 ARG A CG 1 ATOM 555 C CD . ARG A 1 78 ? 30.269 -20.850 -25.624 1.00 24.59 ? 147 ARG A CD 1 ATOM 556 N NE . ARG A 1 78 ? 29.139 -20.332 -26.373 1.00 28.14 ? 147 ARG A NE 1 ATOM 557 C CZ . ARG A 1 78 ? 27.885 -20.314 -25.946 1.00 28.29 ? 147 ARG A CZ 1 ATOM 558 N NH1 . ARG A 1 78 ? 27.595 -20.766 -24.749 1.00 32.56 ? 147 ARG A NH1 1 ATOM 559 N NH2 . ARG A 1 78 ? 26.922 -19.844 -26.714 1.00 27.00 ? 147 ARG A NH2 1 ATOM 560 N N . GLY A 1 79 ? 34.683 -19.004 -28.854 1.00 21.21 ? 148 GLY A N 1 ATOM 561 C CA . GLY A 1 79 ? 34.876 -17.827 -29.709 1.00 21.78 ? 148 GLY A CA 1 ATOM 562 C C . GLY A 1 79 ? 34.893 -18.237 -31.176 1.00 22.33 ? 148 GLY A C 1 ATOM 563 O O . GLY A 1 79 ? 34.929 -19.413 -31.491 1.00 21.96 ? 148 GLY A O 1 ATOM 564 N N . ASP A 1 80 ? 34.832 -17.252 -32.063 1.00 23.48 ? 149 ASP A N 1 ATOM 565 C CA . ASP A 1 80 ? 34.782 -17.455 -33.509 1.00 23.97 ? 149 ASP A CA 1 ATOM 566 C C . ASP A 1 80 ? 36.172 -17.278 -34.125 1.00 23.84 ? 149 ASP A C 1 ATOM 567 O O . ASP A 1 80 ? 36.609 -18.069 -34.978 1.00 24.25 ? 149 ASP A O 1 ATOM 568 C CB . ASP A 1 80 ? 33.859 -16.400 -34.120 1.00 24.92 ? 149 ASP A CB 1 ATOM 569 C CG . ASP A 1 80 ? 32.387 -16.617 -33.789 1.00 27.54 ? 149 ASP A CG 1 ATOM 570 O OD1 . ASP A 1 80 ? 31.898 -17.776 -33.824 1.00 30.41 ? 149 ASP A OD1 1 ATOM 571 O OD2 . ASP A 1 80 ? 31.707 -15.602 -33.524 1.00 31.46 ? 149 ASP A OD2 1 ATOM 572 N N . ARG A 1 81 ? 36.873 -16.233 -33.664 1.00 23.03 ? 150 ARG A N 1 ATOM 573 C CA . ARG A 1 81 ? 38.089 -15.752 -34.308 1.00 21.81 ? 150 ARG A CA 1 ATOM 574 C C . ARG A 1 81 ? 39.298 -15.916 -33.402 1.00 20.90 ? 150 ARG A C 1 ATOM 575 O O . ARG A 1 81 ? 39.288 -15.523 -32.243 1.00 20.40 ? 150 ARG A O 1 ATOM 576 C CB . ARG A 1 81 ? 37.887 -14.302 -34.723 1.00 21.26 ? 150 ARG A CB 1 ATOM 577 C CG . ARG A 1 81 ? 36.755 -14.171 -35.734 1.00 21.60 ? 150 ARG A CG 1 ATOM 578 C CD . ARG A 1 81 ? 36.600 -12.772 -36.285 1.00 22.81 ? 150 ARG A CD 1 ATOM 579 N NE . ARG A 1 81 ? 36.477 -11.800 -35.194 1.00 24.39 ? 150 ARG A NE 1 ATOM 580 C CZ . ARG A 1 81 ? 35.386 -11.617 -34.462 1.00 25.35 ? 150 ARG A CZ 1 ATOM 581 N NH1 . ARG A 1 81 ? 34.297 -12.323 -34.691 1.00 25.44 ? 150 ARG A NH1 1 ATOM 582 N NH2 . ARG A 1 81 ? 35.381 -10.715 -33.488 1.00 27.81 ? 150 ARG A NH2 1 ATOM 583 N N . ASN A 1 82 ? 40.313 -16.564 -33.941 1.00 20.16 ? 151 ASN A N 1 ATOM 584 C CA . ASN A 1 82 ? 41.628 -16.673 -33.307 1.00 19.65 ? 151 ASN A CA 1 ATOM 585 C C . ASN A 1 82 ? 42.622 -17.159 -34.341 1.00 18.49 ? 151 ASN A C 1 ATOM 586 O O . ASN A 1 82 ? 42.229 -17.613 -35.424 1.00 18.38 ? 151 ASN A O 1 ATOM 587 C CB . ASN A 1 82 ? 41.645 -17.562 -32.027 1.00 19.51 ? 151 ASN A CB 1 ATOM 588 C CG . ASN A 1 82 ? 41.149 -18.992 -32.257 1.00 21.37 ? 151 ASN A CG 1 ATOM 589 O OD1 . ASN A 1 82 ? 41.622 -19.726 -33.160 1.00 20.56 ? 151 ASN A OD1 1 ATOM 590 N ND2 . ASN A 1 82 ? 40.230 -19.425 -31.387 1.00 19.16 ? 151 ASN A ND2 1 ATOM 591 N N . LYS A 1 83 ? 43.905 -17.079 -33.985 1.00 17.42 ? 152 LYS A N 1 ATOM 592 C CA . LYS A 1 83 ? 45.005 -17.393 -34.897 1.00 16.40 ? 152 LYS A CA 1 ATOM 593 C C . LYS A 1 83 ? 45.251 -18.894 -35.167 1.00 16.03 ? 152 LYS A C 1 ATOM 594 O O . LYS A 1 83 ? 46.165 -19.237 -35.926 1.00 15.66 ? 152 LYS A O 1 ATOM 595 C CB . LYS A 1 83 ? 46.274 -16.760 -34.354 1.00 16.26 ? 152 LYS A CB 1 ATOM 596 C CG . LYS A 1 83 ? 46.299 -15.230 -34.379 1.00 15.61 ? 152 LYS A CG 1 ATOM 597 C CD . LYS A 1 83 ? 47.505 -14.722 -33.581 1.00 12.86 ? 152 LYS A CD 1 ATOM 598 C CE . LYS A 1 83 ? 47.464 -13.236 -33.388 1.00 12.25 ? 152 LYS A CE 1 ATOM 599 N NZ . LYS A 1 83 ? 48.735 -12.817 -32.741 1.00 12.28 ? 152 LYS A NZ 1 ATOM 600 N N . LEU A 1 84 ? 44.463 -19.779 -34.545 1.00 15.57 ? 153 LEU A N 1 ATOM 601 C CA . LEU A 1 84 ? 44.571 -21.248 -34.738 1.00 15.06 ? 153 LEU A CA 1 ATOM 602 C C . LEU A 1 84 ? 43.475 -21.854 -35.573 1.00 15.46 ? 153 LEU A C 1 ATOM 603 O O . LEU A 1 84 ? 43.590 -23.000 -36.048 1.00 16.53 ? 153 LEU A O 1 ATOM 604 C CB . LEU A 1 84 ? 44.486 -21.943 -33.391 1.00 14.91 ? 153 LEU A CB 1 ATOM 605 C CG . LEU A 1 84 ? 45.709 -21.730 -32.544 1.00 14.64 ? 153 LEU A CG 1 ATOM 606 C CD1 . LEU A 1 84 ? 45.339 -22.080 -31.070 1.00 15.09 ? 153 LEU A CD1 1 ATOM 607 C CD2 . LEU A 1 84 ? 46.810 -22.613 -33.105 1.00 10.90 ? 153 LEU A CD2 1 ATOM 608 N N . ARG A 1 85 ? 42.381 -21.116 -35.692 1.00 15.29 ? 154 ARG A N 1 ATOM 609 C CA . ARG A 1 85 ? 41.232 -21.545 -36.450 1.00 15.48 ? 154 ARG A CA 1 ATOM 610 C C . ARG A 1 85 ? 41.635 -21.931 -37.891 1.00 16.07 ? 154 ARG A C 1 ATOM 611 O O . ARG A 1 85 ? 42.488 -21.275 -38.516 1.00 16.32 ? 154 ARG A O 1 ATOM 612 C CB . ARG A 1 85 ? 40.197 -20.418 -36.450 1.00 14.48 ? 154 ARG A CB 1 ATOM 613 C CG . ARG A 1 85 ? 38.814 -20.900 -36.561 1.00 15.79 ? 154 ARG A CG 1 ATOM 614 C CD . ARG A 1 85 ? 38.164 -21.096 -35.187 1.00 15.83 ? 154 ARG A CD 1 ATOM 615 N NE . ARG A 1 85 ? 37.036 -22.013 -35.285 1.00 13.30 ? 154 ARG A NE 1 ATOM 616 C CZ . ARG A 1 85 ? 35.781 -21.682 -35.562 1.00 13.33 ? 154 ARG A CZ 1 ATOM 617 N NH1 . ARG A 1 85 ? 35.411 -20.428 -35.751 1.00 16.34 ? 154 ARG A NH1 1 ATOM 618 N NH2 . ARG A 1 85 ? 34.872 -22.631 -35.646 1.00 12.21 ? 154 ARG A NH2 1 ATOM 619 N N . HIS A 1 86 ? 41.021 -22.995 -38.411 1.00 16.54 ? 155 HIS A N 1 ATOM 620 C CA . HIS A 1 86 ? 41.371 -23.512 -39.743 1.00 16.53 ? 155 HIS A CA 1 ATOM 621 C C . HIS A 1 86 ? 40.185 -24.106 -40.482 1.00 15.65 ? 155 HIS A C 1 ATOM 622 O O . HIS A 1 86 ? 39.322 -24.687 -39.857 1.00 14.52 ? 155 HIS A O 1 ATOM 623 C CB . HIS A 1 86 ? 42.426 -24.607 -39.624 1.00 16.67 ? 155 HIS A CB 1 ATOM 624 C CG . HIS A 1 86 ? 43.824 -24.106 -39.705 1.00 18.49 ? 155 HIS A CG 1 ATOM 625 N ND1 . HIS A 1 86 ? 44.406 -23.354 -38.703 1.00 20.17 ? 155 HIS A ND1 1 ATOM 626 C CD2 . HIS A 1 86 ? 44.768 -24.267 -40.660 1.00 19.56 ? 155 HIS A CD2 1 ATOM 627 C CE1 . HIS A 1 86 ? 45.649 -23.073 -39.042 1.00 19.84 ? 155 HIS A CE1 1 ATOM 628 N NE2 . HIS A 1 86 ? 45.893 -23.615 -40.227 1.00 20.52 ? 155 HIS A NE2 1 ATOM 629 N N . LEU A 1 87 ? 40.206 -23.979 -41.817 1.00 15.11 ? 156 LEU A N 1 ATOM 630 C CA . LEU A 1 87 ? 39.304 -24.710 -42.713 1.00 15.19 ? 156 LEU A CA 1 ATOM 631 C C . LEU A 1 87 ? 39.826 -26.135 -42.900 1.00 15.28 ? 156 LEU A C 1 ATOM 632 O O . LEU A 1 87 ? 40.959 -26.312 -43.330 1.00 16.23 ? 156 LEU A O 1 ATOM 633 C CB . LEU A 1 87 ? 39.236 -24.022 -44.075 1.00 15.61 ? 156 LEU A CB 1 ATOM 634 C CG . LEU A 1 87 ? 38.295 -24.598 -45.143 1.00 16.60 ? 156 LEU A CG 1 ATOM 635 C CD1 . LEU A 1 87 ? 36.802 -24.534 -44.799 1.00 15.03 ? 156 LEU A CD1 1 ATOM 636 C CD2 . LEU A 1 87 ? 38.582 -23.892 -46.475 1.00 16.43 ? 156 LEU A CD2 1 ATOM 637 N N . ILE A 1 88 ? 38.987 -27.134 -42.596 1.00 14.68 ? 157 ILE A N 1 ATOM 638 C CA . ILE A 1 88 ? 39.328 -28.542 -42.692 1.00 13.92 ? 157 ILE A CA 1 ATOM 639 C C . ILE A 1 88 ? 38.222 -29.303 -43.438 1.00 14.42 ? 157 ILE A C 1 ATOM 640 O O . ILE A 1 88 ? 37.083 -28.827 -43.544 1.00 14.74 ? 157 ILE A O 1 ATOM 641 C CB . ILE A 1 88 ? 39.513 -29.200 -41.270 1.00 13.56 ? 157 ILE A CB 1 ATOM 642 C CG1 . ILE A 1 88 ? 38.202 -29.265 -40.509 1.00 11.47 ? 157 ILE A CG1 1 ATOM 643 C CG2 . ILE A 1 88 ? 40.568 -28.471 -40.434 1.00 13.76 ? 157 ILE A CG2 1 ATOM 644 C CD1 . ILE A 1 88 ? 37.598 -30.576 -40.548 1.00 10.76 ? 157 ILE A CD1 1 ATOM 645 N N . SER A 1 89 ? 38.557 -30.484 -43.947 1.00 13.82 ? 158 SER A N 1 ATOM 646 C CA . SER A 1 89 ? 37.589 -31.269 -44.708 1.00 13.75 ? 158 SER A CA 1 ATOM 647 C C . SER A 1 89 ? 37.882 -32.743 -44.643 1.00 13.09 ? 158 SER A C 1 ATOM 648 O O . SER A 1 89 ? 39.015 -33.150 -44.448 1.00 13.58 ? 158 SER A O 1 ATOM 649 C CB . SER A 1 89 ? 37.474 -30.774 -46.179 1.00 14.26 ? 158 SER A CB 1 ATOM 650 O OG . SER A 1 89 ? 38.439 -31.326 -47.062 1.00 13.64 ? 158 SER A OG 1 ATOM 651 N N . VAL A 1 90 ? 36.831 -33.528 -44.726 1.00 13.29 ? 159 VAL A N 1 ATOM 652 C CA . VAL A 1 90 ? 36.932 -34.976 -44.908 1.00 14.34 ? 159 VAL A CA 1 ATOM 653 C C . VAL A 1 90 ? 36.008 -35.280 -46.101 1.00 15.29 ? 159 VAL A C 1 ATOM 654 O O . VAL A 1 90 ? 35.099 -34.507 -46.385 1.00 14.84 ? 159 VAL A O 1 ATOM 655 C CB . VAL A 1 90 ? 36.439 -35.758 -43.654 1.00 13.79 ? 159 VAL A CB 1 ATOM 656 C CG1 . VAL A 1 90 ? 37.474 -35.764 -42.546 1.00 15.38 ? 159 VAL A CG1 1 ATOM 657 C CG2 . VAL A 1 90 ? 35.173 -35.167 -43.117 1.00 12.56 ? 159 VAL A CG2 1 ATOM 658 N N . LYS A 1 91 ? 36.219 -36.395 -46.784 1.00 17.43 ? 160 LYS A N 1 ATOM 659 C CA . LYS A 1 91 ? 35.177 -36.955 -47.638 1.00 18.85 ? 160 LYS A CA 1 ATOM 660 C C . LYS A 1 91 ? 33.906 -37.122 -46.810 1.00 19.23 ? 160 LYS A C 1 ATOM 661 O O . LYS A 1 91 ? 33.946 -37.671 -45.706 1.00 20.23 ? 160 LYS A O 1 ATOM 662 C CB . LYS A 1 91 ? 35.610 -38.306 -48.190 1.00 19.65 ? 160 LYS A CB 1 ATOM 663 C CG . LYS A 1 91 ? 34.738 -38.882 -49.317 1.00 21.48 ? 160 LYS A CG 1 ATOM 664 C CD . LYS A 1 91 ? 35.127 -40.348 -49.574 1.00 25.14 ? 160 LYS A CD 1 ATOM 665 C CE . LYS A 1 91 ? 34.407 -40.973 -50.775 1.00 27.38 ? 160 LYS A CE 1 ATOM 666 N NZ . LYS A 1 91 ? 34.784 -40.257 -52.045 1.00 29.86 ? 160 LYS A NZ 1 ATOM 667 N N . LEU A 1 92 ? 32.787 -36.630 -47.340 1.00 19.65 ? 161 LEU A N 1 ATOM 668 C CA . LEU A 1 92 ? 31.499 -36.757 -46.682 1.00 19.23 ? 161 LEU A CA 1 ATOM 669 C C . LEU A 1 92 ? 31.179 -38.235 -46.450 1.00 19.43 ? 161 LEU A C 1 ATOM 670 O O . LEU A 1 92 ? 31.135 -39.038 -47.379 1.00 19.78 ? 161 LEU A O 1 ATOM 671 C CB . LEU A 1 92 ? 30.413 -36.093 -47.514 1.00 19.52 ? 161 LEU A CB 1 ATOM 672 C CG . LEU A 1 92 ? 28.942 -36.260 -47.145 1.00 19.59 ? 161 LEU A CG 1 ATOM 673 C CD1 . LEU A 1 92 ? 28.642 -35.708 -45.743 1.00 19.29 ? 161 LEU A CD1 1 ATOM 674 C CD2 . LEU A 1 92 ? 28.060 -35.608 -48.231 1.00 19.26 ? 161 LEU A CD2 1 ATOM 675 N N . GLY A 1 93 ? 30.932 -38.567 -45.191 1.00 19.38 ? 162 GLY A N 1 ATOM 676 C CA . GLY A 1 93 ? 30.715 -39.929 -44.784 1.00 19.26 ? 162 GLY A CA 1 ATOM 677 C C . GLY A 1 93 ? 31.785 -40.346 -43.807 1.00 18.89 ? 162 GLY A C 1 ATOM 678 O O . GLY A 1 93 ? 31.596 -41.315 -43.094 1.00 19.63 ? 162 GLY A O 1 ATOM 679 N N . LYS A 1 94 ? 32.903 -39.623 -43.767 1.00 18.77 ? 163 LYS A N 1 ATOM 680 C CA . LYS A 1 94 ? 33.968 -39.915 -42.818 1.00 18.42 ? 163 LYS A CA 1 ATOM 681 C C . LYS A 1 94 ? 33.809 -39.039 -41.615 1.00 17.89 ? 163 LYS A C 1 ATOM 682 O O . LYS A 1 94 ? 33.410 -37.887 -41.728 1.00 18.00 ? 163 LYS A O 1 ATOM 683 C CB . LYS A 1 94 ? 35.342 -39.665 -43.427 1.00 19.12 ? 163 LYS A CB 1 ATOM 684 C CG . LYS A 1 94 ? 35.629 -40.456 -44.705 1.00 20.51 ? 163 LYS A CG 1 ATOM 685 C CD . LYS A 1 94 ? 35.734 -41.968 -44.453 1.00 22.16 ? 163 LYS A CD 1 ATOM 686 C CE . LYS A 1 94 ? 37.145 -42.403 -44.110 1.00 22.24 ? 163 LYS A CE 1 ATOM 687 N NZ . LYS A 1 94 ? 37.249 -43.896 -43.958 1.00 23.19 ? 163 LYS A NZ 1 ATOM 688 N N . ILE A 1 95 ? 34.135 -39.582 -40.450 1.00 17.11 ? 164 ILE A N 1 ATOM 689 C CA . ILE A 1 95 ? 34.125 -38.795 -39.243 1.00 16.30 ? 164 ILE A CA 1 ATOM 690 C C . ILE A 1 95 ? 35.312 -37.819 -39.277 1.00 16.13 ? 164 ILE A C 1 ATOM 691 O O . ILE A 1 95 ? 36.446 -38.254 -39.469 1.00 15.67 ? 164 ILE A O 1 ATOM 692 C CB . ILE A 1 95 ? 34.239 -39.690 -37.990 1.00 15.80 ? 164 ILE A CB 1 ATOM 693 C CG1 . ILE A 1 95 ? 33.081 -40.703 -37.935 1.00 16.07 ? 164 ILE A CG1 1 ATOM 694 C CG2 . ILE A 1 95 ? 34.263 -38.847 -36.774 1.00 15.12 ? 164 ILE A CG2 1 ATOM 695 C CD1 . ILE A 1 95 ? 31.688 -40.112 -38.210 1.00 14.59 ? 164 ILE A CD1 1 ATOM 696 N N . PRO A 1 96 ? 35.069 -36.503 -39.048 1.00 16.47 ? 165 PRO A N 1 ATOM 697 C CA . PRO A 1 96 ? 36.187 -35.510 -39.010 1.00 16.53 ? 165 PRO A CA 1 ATOM 698 C C . PRO A 1 96 ? 37.068 -35.562 -37.753 1.00 17.04 ? 165 PRO A C 1 ATOM 699 O O . PRO A 1 96 ? 36.825 -34.842 -36.765 1.00 17.28 ? 165 PRO A O 1 ATOM 700 C CB . PRO A 1 96 ? 35.475 -34.146 -39.133 1.00 16.56 ? 165 PRO A CB 1 ATOM 701 C CG . PRO A 1 96 ? 34.035 -34.403 -38.948 1.00 15.90 ? 165 PRO A CG 1 ATOM 702 C CD . PRO A 1 96 ? 33.761 -35.873 -38.807 1.00 15.79 ? 165 PRO A CD 1 ATOM 703 N N . THR A 1 97 ? 38.091 -36.412 -37.796 1.00 17.24 ? 166 THR A N 1 ATOM 704 C CA . THR A 1 97 ? 39.005 -36.588 -36.670 1.00 17.55 ? 166 THR A CA 1 ATOM 705 C C . THR A 1 97 ? 40.342 -35.961 -36.984 1.00 17.82 ? 166 THR A C 1 ATOM 706 O O . THR A 1 97 ? 40.592 -35.532 -38.105 1.00 18.59 ? 166 THR A O 1 ATOM 707 C CB . THR A 1 97 ? 39.305 -38.052 -36.376 1.00 17.35 ? 166 THR A CB 1 ATOM 708 O OG1 . THR A 1 97 ? 39.910 -38.631 -37.530 1.00 16.75 ? 166 THR A OG1 1 ATOM 709 C CG2 . THR A 1 97 ? 38.052 -38.802 -36.002 1.00 17.70 ? 166 THR A CG2 1 ATOM 710 N N . VAL A 1 98 ? 41.198 -35.935 -35.971 1.00 17.58 ? 167 VAL A N 1 ATOM 711 C CA . VAL A 1 98 ? 42.560 -35.460 -36.092 1.00 17.57 ? 167 VAL A CA 1 ATOM 712 C C . VAL A 1 98 ? 43.254 -36.057 -37.305 1.00 18.04 ? 167 VAL A C 1 ATOM 713 O O . VAL A 1 98 ? 43.941 -35.344 -38.028 1.00 18.37 ? 167 VAL A O 1 ATOM 714 C CB . VAL A 1 98 ? 43.394 -35.793 -34.813 1.00 17.09 ? 167 VAL A CB 1 ATOM 715 C CG1 . VAL A 1 98 ? 44.844 -35.443 -35.026 1.00 15.26 ? 167 VAL A CG1 1 ATOM 716 C CG2 . VAL A 1 98 ? 42.832 -35.067 -33.602 1.00 16.50 ? 167 VAL A CG2 1 ATOM 717 N N . GLU A 1 99 ? 43.072 -37.361 -37.506 1.00 18.99 ? 168 GLU A N 1 ATOM 718 C CA . GLU A 1 99 ? 43.760 -38.107 -38.566 1.00 19.72 ? 168 GLU A CA 1 ATOM 719 C C . GLU A 1 99 ? 43.045 -38.160 -39.908 1.00 19.47 ? 168 GLU A C 1 ATOM 720 O O . GLU A 1 99 ? 43.693 -38.206 -40.969 1.00 18.75 ? 168 GLU A O 1 ATOM 721 C CB . GLU A 1 99 ? 44.045 -39.532 -38.116 1.00 19.81 ? 168 GLU A CB 1 ATOM 722 C CG . GLU A 1 99 ? 45.519 -39.744 -37.889 1.00 24.09 ? 168 GLU A CG 1 ATOM 723 C CD . GLU A 1 99 ? 45.804 -40.810 -36.887 1.00 25.62 ? 168 GLU A CD 1 ATOM 724 O OE1 . GLU A 1 99 ? 45.031 -41.802 -36.858 1.00 33.21 ? 168 GLU A OE1 1 ATOM 725 O OE2 . GLU A 1 99 ? 46.791 -40.659 -36.153 1.00 25.55 ? 168 GLU A OE2 1 ATOM 726 N N . ASN A 1 100 ? 41.718 -38.190 -39.870 1.00 19.10 ? 169 ASN A N 1 ATOM 727 C CA . ASN A 1 100 ? 40.961 -38.282 -41.106 1.00 18.85 ? 169 ASN A CA 1 ATOM 728 C C . ASN A 1 100 ? 40.991 -36.976 -41.907 1.00 19.16 ? 169 ASN A C 1 ATOM 729 O O . ASN A 1 100 ? 40.990 -36.999 -43.133 1.00 18.79 ? 169 ASN A O 1 ATOM 730 C CB . ASN A 1 100 ? 39.519 -38.709 -40.831 1.00 18.42 ? 169 ASN A CB 1 ATOM 731 C CG . ASN A 1 100 ? 39.328 -40.202 -40.920 1.00 17.69 ? 169 ASN A CG 1 ATOM 732 O OD1 . ASN A 1 100 ? 40.234 -40.943 -41.283 1.00 17.02 ? 169 ASN A OD1 1 ATOM 733 N ND2 . ASN A 1 100 ? 38.143 -40.657 -40.572 1.00 19.29 ? 169 ASN A ND2 1 ATOM 734 N N . SER A 1 101 ? 41.007 -35.857 -41.184 1.00 19.18 ? 170 SER A N 1 ATOM 735 C CA . SER A 1 101 ? 40.797 -34.519 -41.764 1.00 18.60 ? 170 SER A CA 1 ATOM 736 C C . SER A 1 101 ? 42.028 -34.036 -42.516 1.00 18.28 ? 170 SER A C 1 ATOM 737 O O . SER A 1 101 ? 43.127 -34.465 -42.220 1.00 18.24 ? 170 SER A O 1 ATOM 738 C CB . SER A 1 101 ? 40.463 -33.516 -40.635 1.00 18.66 ? 170 SER A CB 1 ATOM 739 O OG . SER A 1 101 ? 39.273 -33.873 -39.939 1.00 16.32 ? 170 SER A OG 1 ATOM 740 N N . ILE A 1 102 ? 41.840 -33.182 -43.519 1.00 18.54 ? 171 ILE A N 1 ATOM 741 C CA . ILE A 1 102 ? 42.966 -32.477 -44.127 1.00 18.56 ? 171 ILE A CA 1 ATOM 742 C C . ILE A 1 102 ? 42.773 -30.994 -43.840 1.00 17.95 ? 171 ILE A C 1 ATOM 743 O O . ILE A 1 102 ? 41.653 -30.510 -43.864 1.00 17.80 ? 171 ILE A O 1 ATOM 744 C CB . ILE A 1 102 ? 43.143 -32.811 -45.660 1.00 19.51 ? 171 ILE A CB 1 ATOM 745 C CG1 . ILE A 1 102 ? 44.569 -32.464 -46.120 1.00 19.75 ? 171 ILE A CG1 1 ATOM 746 C CG2 . ILE A 1 102 ? 42.098 -32.120 -46.534 1.00 18.32 ? 171 ILE A CG2 1 ATOM 747 C CD1 . ILE A 1 102 ? 44.719 -32.371 -47.625 1.00 22.04 ? 171 ILE A CD1 1 ATOM 748 N N . PHE A 1 103 ? 43.863 -30.297 -43.521 1.00 17.94 ? 172 PHE A N 1 ATOM 749 C CA . PHE A 1 103 ? 43.829 -28.881 -43.174 1.00 17.61 ? 172 PHE A CA 1 ATOM 750 C C . PHE A 1 103 ? 44.157 -28.078 -44.416 1.00 18.33 ? 172 PHE A C 1 ATOM 751 O O . PHE A 1 103 ? 45.217 -28.274 -45.039 1.00 18.43 ? 172 PHE A O 1 ATOM 752 C CB . PHE A 1 103 ? 44.828 -28.558 -42.042 1.00 17.26 ? 172 PHE A CB 1 ATOM 753 C CG . PHE A 1 103 ? 44.420 -29.087 -40.683 1.00 14.26 ? 172 PHE A CG 1 ATOM 754 C CD1 . PHE A 1 103 ? 44.175 -28.222 -39.629 1.00 13.41 ? 172 PHE A CD1 1 ATOM 755 C CD2 . PHE A 1 103 ? 44.256 -30.459 -40.462 1.00 14.25 ? 172 PHE A CD2 1 ATOM 756 C CE1 . PHE A 1 103 ? 43.788 -28.704 -38.355 1.00 11.43 ? 172 PHE A CE1 1 ATOM 757 C CE2 . PHE A 1 103 ? 43.875 -30.955 -39.204 1.00 11.17 ? 172 PHE A CE2 1 ATOM 758 C CZ . PHE A 1 103 ? 43.653 -30.058 -38.141 1.00 11.84 ? 172 PHE A CZ 1 ATOM 759 N N . HIS A 1 104 ? 43.262 -27.169 -44.786 1.00 19.36 ? 173 HIS A N 1 ATOM 760 C CA . HIS A 1 104 ? 43.389 -26.457 -46.088 1.00 20.39 ? 173 HIS A CA 1 ATOM 761 C C . HIS A 1 104 ? 44.077 -25.120 -45.903 1.00 20.50 ? 173 HIS A C 1 ATOM 762 O O . HIS A 1 104 ? 44.981 -24.765 -46.656 1.00 20.90 ? 173 HIS A O 1 ATOM 763 C CB . HIS A 1 104 ? 42.026 -26.236 -46.747 1.00 20.14 ? 173 HIS A CB 1 ATOM 764 C CG . HIS A 1 104 ? 41.381 -27.490 -47.227 1.00 22.30 ? 173 HIS A CG 1 ATOM 765 N ND1 . HIS A 1 104 ? 41.822 -28.175 -48.339 1.00 23.50 ? 173 HIS A ND1 1 ATOM 766 C CD2 . HIS A 1 104 ? 40.312 -28.179 -46.761 1.00 24.34 ? 173 HIS A CD2 1 ATOM 767 C CE1 . HIS A 1 104 ? 41.067 -29.243 -48.523 1.00 21.65 ? 173 HIS A CE1 1 ATOM 768 N NE2 . HIS A 1 104 ? 40.141 -29.267 -47.582 1.00 22.28 ? 173 HIS A NE2 1 ATOM 769 N N . MET A 1 105 ? 43.642 -24.373 -44.899 1.00 21.23 ? 174 MET A N 1 ATOM 770 C CA . MET A 1 105 ? 44.247 -23.081 -44.616 1.00 21.65 ? 174 MET A CA 1 ATOM 771 C C . MET A 1 105 ? 43.759 -22.500 -43.286 1.00 21.38 ? 174 MET A C 1 ATOM 772 O O . MET A 1 105 ? 42.713 -22.875 -42.761 1.00 21.42 ? 174 MET A O 1 ATOM 773 C CB . MET A 1 105 ? 43.984 -22.089 -45.769 1.00 21.63 ? 174 MET A CB 1 ATOM 774 C CG . MET A 1 105 ? 42.608 -21.503 -45.827 1.00 22.40 ? 174 MET A CG 1 ATOM 775 S SD . MET A 1 105 ? 42.568 -20.137 -47.023 1.00 27.26 ? 174 MET A SD 1 ATOM 776 C CE . MET A 1 105 ? 42.173 -21.094 -48.505 1.00 21.01 ? 174 MET A CE 1 ATOM 777 N N . ALA A 1 106 ? 44.530 -21.563 -42.764 1.00 21.14 ? 175 ALA A N 1 ATOM 778 C CA . ALA A 1 106 ? 44.136 -20.837 -41.571 1.00 21.13 ? 175 ALA A CA 1 ATOM 779 C C . ALA A 1 106 ? 42.922 -20.036 -42.002 1.00 20.71 ? 175 ALA A C 1 ATOM 780 O O . ALA A 1 106 ? 42.848 -19.578 -43.154 1.00 21.67 ? 175 ALA A O 1 ATOM 781 C CB . ALA A 1 106 ? 45.271 -19.938 -41.086 1.00 20.81 ? 175 ALA A CB 1 ATOM 782 N N . ALA A 1 107 ? 41.940 -19.952 -41.120 1.00 19.59 ? 176 ALA A N 1 ATOM 783 C CA . ALA A 1 107 ? 40.680 -19.296 -41.433 1.00 18.65 ? 176 ALA A CA 1 ATOM 784 C C . ALA A 1 107 ? 39.757 -19.325 -40.220 1.00 18.14 ? 176 ALA A C 1 ATOM 785 O O . ALA A 1 107 ? 39.698 -20.333 -39.513 1.00 17.27 ? 176 ALA A O 1 ATOM 786 C CB . ALA A 1 107 ? 39.982 -19.951 -42.630 1.00 18.21 ? 176 ALA A CB 1 ATOM 787 N N . TRP A 1 108 ? 39.044 -18.212 -39.998 1.00 17.35 ? 177 TRP A N 1 ATOM 788 C CA . TRP A 1 108 ? 37.892 -18.219 -39.102 1.00 16.54 ? 177 TRP A CA 1 ATOM 789 C C . TRP A 1 108 ? 36.582 -17.890 -39.840 1.00 16.47 ? 177 TRP A C 1 ATOM 790 O O . TRP A 1 108 ? 35.567 -17.675 -39.202 1.00 16.24 ? 177 TRP A O 1 ATOM 791 C CB . TRP A 1 108 ? 38.126 -17.342 -37.843 1.00 16.29 ? 177 TRP A CB 1 ATOM 792 C CG . TRP A 1 108 ? 38.866 -16.102 -38.040 1.00 13.59 ? 177 TRP A CG 1 ATOM 793 C CD1 . TRP A 1 108 ? 40.159 -15.850 -37.679 1.00 15.30 ? 177 TRP A CD1 1 ATOM 794 C CD2 . TRP A 1 108 ? 38.374 -14.904 -38.635 1.00 12.47 ? 177 TRP A CD2 1 ATOM 795 N NE1 . TRP A 1 108 ? 40.501 -14.571 -38.014 1.00 13.59 ? 177 TRP A NE1 1 ATOM 796 C CE2 . TRP A 1 108 ? 39.415 -13.966 -38.600 1.00 14.42 ? 177 TRP A CE2 1 ATOM 797 C CE3 . TRP A 1 108 ? 37.150 -14.536 -39.197 1.00 12.24 ? 177 TRP A CE3 1 ATOM 798 C CZ2 . TRP A 1 108 ? 39.263 -12.679 -39.091 1.00 13.86 ? 177 TRP A CZ2 1 ATOM 799 C CZ3 . TRP A 1 108 ? 36.998 -13.281 -39.681 1.00 13.49 ? 177 TRP A CZ3 1 ATOM 800 C CH2 . TRP A 1 108 ? 38.045 -12.361 -39.633 1.00 15.16 ? 177 TRP A CH2 1 ATOM 801 N N . SER A 1 109 ? 36.627 -17.897 -41.183 1.00 16.25 ? 178 SER A N 1 ATOM 802 C CA . SER A 1 109 ? 35.445 -17.835 -42.056 1.00 15.54 ? 178 SER A CA 1 ATOM 803 C C . SER A 1 109 ? 35.774 -18.453 -43.416 1.00 15.82 ? 178 SER A C 1 ATOM 804 O O . SER A 1 109 ? 36.860 -18.268 -43.948 1.00 15.39 ? 178 SER A O 1 ATOM 805 C CB . SER A 1 109 ? 34.920 -16.409 -42.248 1.00 15.63 ? 178 SER A CB 1 ATOM 806 O OG . SER A 1 109 ? 33.695 -16.378 -42.986 1.00 13.47 ? 178 SER A OG 1 ATOM 807 N N . GLY A 1 110 ? 34.811 -19.188 -43.968 1.00 16.11 ? 179 GLY A N 1 ATOM 808 C CA . GLY A 1 110 ? 35.085 -20.208 -44.994 1.00 15.90 ? 179 GLY A CA 1 ATOM 809 C C . GLY A 1 110 ? 34.036 -20.397 -46.084 1.00 16.28 ? 179 GLY A C 1 ATOM 810 O O . GLY A 1 110 ? 32.874 -20.095 -45.907 1.00 14.97 ? 179 GLY A O 1 ATOM 811 N N . SER A 1 111 ? 34.507 -20.874 -47.236 1.00 17.58 ? 180 SER A N 1 ATOM 812 C CA . SER A 1 111 ? 33.686 -21.329 -48.350 1.00 17.76 ? 180 SER A CA 1 ATOM 813 C C . SER A 1 111 ? 34.533 -22.288 -49.166 1.00 17.81 ? 180 SER A C 1 ATOM 814 O O . SER A 1 111 ? 35.755 -22.350 -48.985 1.00 17.46 ? 180 SER A O 1 ATOM 815 C CB . SER A 1 111 ? 33.212 -20.171 -49.237 1.00 17.89 ? 180 SER A CB 1 ATOM 816 O OG . SER A 1 111 ? 32.442 -20.673 -50.327 1.00 18.50 ? 180 SER A OG 1 ATOM 817 N N . ALA A 1 112 ? 33.887 -23.070 -50.032 1.00 18.18 ? 181 ALA A N 1 ATOM 818 C CA . ALA A 1 112 ? 34.617 -23.873 -51.018 1.00 18.25 ? 181 ALA A CA 1 ATOM 819 C C . ALA A 1 112 ? 33.677 -24.356 -52.114 1.00 18.72 ? 181 ALA A C 1 ATOM 820 O O . ALA A 1 112 ? 32.478 -24.527 -51.848 1.00 18.25 ? 181 ALA A O 1 ATOM 821 C CB . ALA A 1 112 ? 35.278 -25.044 -50.359 1.00 18.13 ? 181 ALA A CB 1 ATOM 822 N N . CYS A 1 113 ? 34.220 -24.569 -53.324 1.00 18.34 ? 182 CYS A N 1 ATOM 823 C CA . CYS A 1 113 ? 33.454 -25.156 -54.451 1.00 18.91 ? 182 CYS A CA 1 ATOM 824 C C . CYS A 1 113 ? 34.319 -25.841 -55.525 1.00 18.65 ? 182 CYS A C 1 ATOM 825 O O . CYS A 1 113 ? 35.510 -25.576 -55.629 1.00 19.18 ? 182 CYS A O 1 ATOM 826 C CB . CYS A 1 113 ? 32.568 -24.101 -55.128 1.00 18.34 ? 182 CYS A CB 1 ATOM 827 S SG . CYS A 1 113 ? 33.368 -22.561 -55.493 1.00 21.68 ? 182 CYS A SG 1 ATOM 828 N N . HIS A 1 114 ? 33.686 -26.675 -56.341 1.00 18.12 ? 183 HIS A N 1 ATOM 829 C CA . HIS A 1 114 ? 34.356 -27.382 -57.426 1.00 18.31 ? 183 HIS A CA 1 ATOM 830 C C . HIS A 1 114 ? 33.777 -26.938 -58.774 1.00 18.25 ? 183 HIS A C 1 ATOM 831 O O . HIS A 1 114 ? 32.569 -27.013 -58.982 1.00 18.05 ? 183 HIS A O 1 ATOM 832 C CB . HIS A 1 114 ? 34.185 -28.897 -57.237 1.00 18.23 ? 183 HIS A CB 1 ATOM 833 C CG . HIS A 1 114 ? 35.089 -29.728 -58.090 1.00 19.40 ? 183 HIS A CG 1 ATOM 834 N ND1 . HIS A 1 114 ? 36.033 -30.594 -57.567 1.00 20.01 ? 183 HIS A ND1 1 ATOM 835 C CD2 . HIS A 1 114 ? 35.188 -29.829 -59.439 1.00 18.53 ? 183 HIS A CD2 1 ATOM 836 C CE1 . HIS A 1 114 ? 36.681 -31.176 -58.567 1.00 21.61 ? 183 HIS A CE1 1 ATOM 837 N NE2 . HIS A 1 114 ? 36.179 -30.735 -59.713 1.00 18.70 ? 183 HIS A NE2 1 ATOM 838 N N . ASP A 1 115 ? 34.645 -26.501 -59.686 1.00 18.00 ? 184 ASP A N 1 ATOM 839 C CA . ASP A 1 115 ? 34.217 -25.952 -60.972 1.00 17.87 ? 184 ASP A CA 1 ATOM 840 C C . ASP A 1 115 ? 34.032 -26.978 -62.100 1.00 18.37 ? 184 ASP A C 1 ATOM 841 O O . ASP A 1 115 ? 33.686 -26.612 -63.221 1.00 18.53 ? 184 ASP A O 1 ATOM 842 C CB . ASP A 1 115 ? 35.146 -24.794 -61.435 1.00 17.80 ? 184 ASP A CB 1 ATOM 843 C CG . ASP A 1 115 ? 36.624 -25.198 -61.650 1.00 17.41 ? 184 ASP A CG 1 ATOM 844 O OD1 . ASP A 1 115 ? 36.957 -26.377 -61.841 1.00 18.76 ? 184 ASP A OD1 1 ATOM 845 O OD2 . ASP A 1 115 ? 37.482 -24.287 -61.691 1.00 16.70 ? 184 ASP A OD2 1 ATOM 846 N N . GLY A 1 116 ? 34.196 -28.254 -61.782 1.00 18.22 ? 185 GLY A N 1 ATOM 847 C CA . GLY A 1 116 ? 34.262 -29.323 -62.782 1.00 18.28 ? 185 GLY A CA 1 ATOM 848 C C . GLY A 1 116 ? 35.666 -29.850 -62.995 1.00 18.79 ? 185 GLY A C 1 ATOM 849 O O . GLY A 1 116 ? 35.841 -31.013 -63.363 1.00 18.07 ? 185 GLY A O 1 ATOM 850 N N . LYS A 1 117 ? 36.679 -28.999 -62.758 1.00 19.64 ? 186 LYS A N 1 ATOM 851 C CA . LYS A 1 117 ? 38.083 -29.406 -62.930 1.00 20.22 ? 186 LYS A CA 1 ATOM 852 C C . LYS A 1 117 ? 38.834 -29.518 -61.624 1.00 20.51 ? 186 LYS A C 1 ATOM 853 O O . LYS A 1 117 ? 39.653 -30.437 -61.461 1.00 20.50 ? 186 LYS A O 1 ATOM 854 C CB . LYS A 1 117 ? 38.835 -28.448 -63.851 1.00 20.06 ? 186 LYS A CB 1 ATOM 855 C CG . LYS A 1 117 ? 38.453 -28.627 -65.297 1.00 21.81 ? 186 LYS A CG 1 ATOM 856 C CD . LYS A 1 117 ? 39.250 -27.730 -66.216 1.00 23.45 ? 186 LYS A CD 1 ATOM 857 C CE . LYS A 1 117 ? 38.586 -27.659 -67.605 1.00 24.51 ? 186 LYS A CE 1 ATOM 858 N NZ . LYS A 1 117 ? 39.305 -26.691 -68.457 1.00 25.86 ? 186 LYS A NZ 1 ATOM 859 N N . GLU A 1 118 ? 38.571 -28.586 -60.710 1.00 20.52 ? 187 GLU A N 1 ATOM 860 C CA . GLU A 1 118 ? 39.358 -28.470 -59.512 1.00 20.69 ? 187 GLU A CA 1 ATOM 861 C C . GLU A 1 118 ? 38.580 -27.803 -58.369 1.00 20.15 ? 187 GLU A C 1 ATOM 862 O O . GLU A 1 118 ? 37.569 -27.127 -58.585 1.00 19.98 ? 187 GLU A O 1 ATOM 863 C CB . GLU A 1 118 ? 40.629 -27.693 -59.893 1.00 21.21 ? 187 GLU A CB 1 ATOM 864 C CG . GLU A 1 118 ? 41.689 -27.491 -58.815 1.00 22.93 ? 187 GLU A CG 1 ATOM 865 C CD . GLU A 1 118 ? 42.226 -28.796 -58.225 1.00 26.67 ? 187 GLU A CD 1 ATOM 866 O OE1 . GLU A 1 118 ? 43.340 -29.211 -58.618 1.00 30.73 ? 187 GLU A OE1 1 ATOM 867 O OE2 . GLU A 1 118 ? 41.535 -29.408 -57.376 1.00 27.30 ? 187 GLU A OE2 1 ATOM 868 N N . TRP A 1 119 ? 39.068 -27.999 -57.148 1.00 20.18 ? 188 TRP A N 1 ATOM 869 C CA . TRP A 1 119 ? 38.482 -27.373 -55.949 1.00 19.87 ? 188 TRP A CA 1 ATOM 870 C C . TRP A 1 119 ? 39.033 -25.976 -55.732 1.00 19.65 ? 188 TRP A C 1 ATOM 871 O O . TRP A 1 119 ? 40.229 -25.741 -55.944 1.00 20.14 ? 188 TRP A O 1 ATOM 872 C CB . TRP A 1 119 ? 38.782 -28.211 -54.714 1.00 19.79 ? 188 TRP A CB 1 ATOM 873 C CG . TRP A 1 119 ? 37.934 -29.389 -54.618 1.00 19.13 ? 188 TRP A CG 1 ATOM 874 C CD1 . TRP A 1 119 ? 38.228 -30.646 -55.014 1.00 19.70 ? 188 TRP A CD1 1 ATOM 875 C CD2 . TRP A 1 119 ? 36.620 -29.434 -54.069 1.00 19.55 ? 188 TRP A CD2 1 ATOM 876 N NE1 . TRP A 1 119 ? 37.173 -31.483 -54.758 1.00 18.00 ? 188 TRP A NE1 1 ATOM 877 C CE2 . TRP A 1 119 ? 36.170 -30.758 -54.180 1.00 19.42 ? 188 TRP A CE2 1 ATOM 878 C CE3 . TRP A 1 119 ? 35.770 -28.472 -53.517 1.00 19.30 ? 188 TRP A CE3 1 ATOM 879 C CZ2 . TRP A 1 119 ? 34.914 -31.156 -53.742 1.00 21.51 ? 188 TRP A CZ2 1 ATOM 880 C CZ3 . TRP A 1 119 ? 34.530 -28.864 -53.082 1.00 21.15 ? 188 TRP A CZ3 1 ATOM 881 C CH2 . TRP A 1 119 ? 34.108 -30.194 -53.200 1.00 21.66 ? 188 TRP A CH2 1 ATOM 882 N N . THR A 1 120 ? 38.156 -25.051 -55.342 1.00 19.25 ? 189 THR A N 1 ATOM 883 C CA . THR A 1 120 ? 38.555 -23.721 -54.899 1.00 18.85 ? 189 THR A CA 1 ATOM 884 C C . THR A 1 120 ? 38.250 -23.682 -53.395 1.00 19.20 ? 189 THR A C 1 ATOM 885 O O . THR A 1 120 ? 37.196 -24.108 -52.978 1.00 19.06 ? 189 THR A O 1 ATOM 886 C CB . THR A 1 120 ? 37.819 -22.613 -55.697 1.00 19.27 ? 189 THR A CB 1 ATOM 887 O OG1 . THR A 1 120 ? 38.144 -22.717 -57.105 1.00 16.48 ? 189 THR A OG1 1 ATOM 888 C CG2 . THR A 1 120 ? 38.195 -21.226 -55.183 1.00 16.82 ? 189 THR A CG2 1 ATOM 889 N N . TYR A 1 121 ? 39.206 -23.244 -52.583 1.00 19.60 ? 190 TYR A N 1 ATOM 890 C CA . TYR A 1 121 ? 39.031 -23.190 -51.119 1.00 19.69 ? 190 TYR A CA 1 ATOM 891 C C . TYR A 1 121 ? 39.237 -21.758 -50.688 1.00 20.27 ? 190 TYR A C 1 ATOM 892 O O . TYR A 1 121 ? 40.258 -21.156 -51.047 1.00 21.47 ? 190 TYR A O 1 ATOM 893 C CB . TYR A 1 121 ? 40.064 -24.041 -50.386 1.00 19.07 ? 190 TYR A CB 1 ATOM 894 C CG . TYR A 1 121 ? 40.175 -25.490 -50.826 1.00 18.31 ? 190 TYR A CG 1 ATOM 895 C CD1 . TYR A 1 121 ? 39.344 -26.453 -50.285 1.00 15.94 ? 190 TYR A CD1 1 ATOM 896 C CD2 . TYR A 1 121 ? 41.135 -25.894 -51.783 1.00 16.63 ? 190 TYR A CD2 1 ATOM 897 C CE1 . TYR A 1 121 ? 39.448 -27.777 -50.654 1.00 16.11 ? 190 TYR A CE1 1 ATOM 898 C CE2 . TYR A 1 121 ? 41.246 -27.224 -52.163 1.00 16.24 ? 190 TYR A CE2 1 ATOM 899 C CZ . TYR A 1 121 ? 40.395 -28.164 -51.584 1.00 16.83 ? 190 TYR A CZ 1 ATOM 900 O OH . TYR A 1 121 ? 40.461 -29.485 -51.911 1.00 14.69 ? 190 TYR A OH 1 ATOM 901 N N . ILE A 1 122 ? 38.296 -21.225 -49.909 1.00 20.07 ? 191 ILE A N 1 ATOM 902 C CA . ILE A 1 122 ? 38.343 -19.832 -49.487 1.00 19.97 ? 191 ILE A CA 1 ATOM 903 C C . ILE A 1 122 ? 38.386 -19.726 -47.959 1.00 19.56 ? 191 ILE A C 1 ATOM 904 O O . ILE A 1 122 ? 37.678 -20.439 -47.256 1.00 20.13 ? 191 ILE A O 1 ATOM 905 C CB . ILE A 1 122 ? 37.165 -19.043 -50.094 1.00 20.19 ? 191 ILE A CB 1 ATOM 906 C CG1 . ILE A 1 122 ? 37.472 -18.746 -51.581 1.00 21.78 ? 191 ILE A CG1 1 ATOM 907 C CG2 . ILE A 1 122 ? 36.937 -17.755 -49.316 1.00 18.57 ? 191 ILE A CG2 1 ATOM 908 C CD1 . ILE A 1 122 ? 36.438 -19.282 -52.564 1.00 24.07 ? 191 ILE A CD1 1 ATOM 909 N N . GLY A 1 123 ? 39.253 -18.863 -47.454 1.00 18.79 ? 192 GLY A N 1 ATOM 910 C CA . GLY A 1 123 ? 39.401 -18.694 -46.004 1.00 18.91 ? 192 GLY A CA 1 ATOM 911 C C . GLY A 1 123 ? 39.766 -17.279 -45.639 1.00 18.36 ? 192 GLY A C 1 ATOM 912 O O . GLY A 1 123 ? 40.676 -16.697 -46.236 1.00 18.18 ? 192 GLY A O 1 ATOM 913 N N . VAL A 1 124 ? 39.042 -16.718 -44.678 1.00 18.49 ? 193 VAL A N 1 ATOM 914 C CA . VAL A 1 124 ? 39.317 -15.376 -44.213 1.00 18.80 ? 193 VAL A CA 1 ATOM 915 C C . VAL A 1 124 ? 40.039 -15.453 -42.871 1.00 19.38 ? 193 VAL A C 1 ATOM 916 O O . VAL A 1 124 ? 39.619 -16.153 -41.920 1.00 18.57 ? 193 VAL A O 1 ATOM 917 C CB . VAL A 1 124 ? 38.048 -14.490 -44.104 1.00 19.00 ? 193 VAL A CB 1 ATOM 918 C CG1 . VAL A 1 124 ? 38.414 -13.093 -43.569 1.00 20.07 ? 193 VAL A CG1 1 ATOM 919 C CG2 . VAL A 1 124 ? 37.352 -14.373 -45.455 1.00 18.19 ? 193 VAL A CG2 1 ATOM 920 N N . ASP A 1 125 ? 41.103 -14.662 -42.812 1.00 19.84 ? 194 ASP A N 1 ATOM 921 C CA . ASP A 1 125 ? 42.052 -14.682 -41.736 1.00 20.62 ? 194 ASP A CA 1 ATOM 922 C C . ASP A 1 125 ? 42.358 -13.251 -41.344 1.00 20.51 ? 194 ASP A C 1 ATOM 923 O O . ASP A 1 125 ? 41.967 -12.312 -42.036 1.00 19.32 ? 194 ASP A O 1 ATOM 924 C CB . ASP A 1 125 ? 43.349 -15.336 -42.248 1.00 21.09 ? 194 ASP A CB 1 ATOM 925 C CG . ASP A 1 125 ? 44.123 -15.974 -41.178 1.00 23.25 ? 194 ASP A CG 1 ATOM 926 O OD1 . ASP A 1 125 ? 43.520 -16.169 -40.106 1.00 28.73 ? 194 ASP A OD1 1 ATOM 927 O OD2 . ASP A 1 125 ? 45.314 -16.297 -41.386 1.00 23.27 ? 194 ASP A OD2 1 ATOM 928 N N . GLY A 1 126 ? 43.093 -13.115 -40.241 1.00 20.68 ? 195 GLY A N 1 ATOM 929 C CA . GLY A 1 126 ? 43.697 -11.851 -39.873 1.00 20.81 ? 195 GLY A CA 1 ATOM 930 C C . GLY A 1 126 ? 42.980 -11.146 -38.735 1.00 20.87 ? 195 GLY A C 1 ATOM 931 O O . GLY A 1 126 ? 42.009 -11.678 -38.185 1.00 21.02 ? 195 GLY A O 1 ATOM 932 N N . PRO A 1 127 ? 43.451 -9.931 -38.402 1.00 20.87 ? 196 PRO A N 1 ATOM 933 C CA . PRO A 1 127 ? 42.899 -9.066 -37.380 1.00 21.09 ? 196 PRO A CA 1 ATOM 934 C C . PRO A 1 127 ? 41.545 -8.515 -37.767 1.00 21.18 ? 196 PRO A C 1 ATOM 935 O O . PRO A 1 127 ? 41.233 -8.368 -38.969 1.00 21.19 ? 196 PRO A O 1 ATOM 936 C CB . PRO A 1 127 ? 43.921 -7.921 -37.305 1.00 21.07 ? 196 PRO A CB 1 ATOM 937 C CG . PRO A 1 127 ? 44.456 -7.835 -38.674 1.00 21.15 ? 196 PRO A CG 1 ATOM 938 C CD . PRO A 1 127 ? 44.560 -9.264 -39.118 1.00 20.97 ? 196 PRO A CD 1 ATOM 939 N N . ASP A 1 128 ? 40.760 -8.197 -36.745 1.00 20.63 ? 197 ASP A N 1 ATOM 940 C CA . ASP A 1 128 ? 39.388 -7.743 -36.927 1.00 21.24 ? 197 ASP A CA 1 ATOM 941 C C . ASP A 1 128 ? 39.273 -6.517 -37.810 1.00 21.45 ? 197 ASP A C 1 ATOM 942 O O . ASP A 1 128 ? 38.348 -6.423 -38.589 1.00 20.42 ? 197 ASP A O 1 ATOM 943 C CB . ASP A 1 128 ? 38.729 -7.452 -35.569 1.00 21.27 ? 197 ASP A CB 1 ATOM 944 C CG . ASP A 1 128 ? 38.282 -8.707 -34.861 1.00 21.64 ? 197 ASP A CG 1 ATOM 945 O OD1 . ASP A 1 128 ? 38.607 -9.843 -35.308 1.00 20.06 ? 197 ASP A OD1 1 ATOM 946 O OD2 . ASP A 1 128 ? 37.584 -8.559 -33.844 1.00 25.67 ? 197 ASP A OD2 1 ATOM 947 N N . ASN A 1 129 ? 40.206 -5.577 -37.667 1.00 22.66 ? 198 ASN A N 1 ATOM 948 C CA . ASN A 1 129 ? 40.173 -4.327 -38.435 1.00 23.36 ? 198 ASN A CA 1 ATOM 949 C C . ASN A 1 129 ? 40.828 -4.357 -39.817 1.00 23.38 ? 198 ASN A C 1 ATOM 950 O O . ASN A 1 129 ? 40.721 -3.387 -40.587 1.00 23.39 ? 198 ASN A O 1 ATOM 951 C CB . ASN A 1 129 ? 40.762 -3.179 -37.620 1.00 23.42 ? 198 ASN A CB 1 ATOM 952 C CG . ASN A 1 129 ? 42.225 -3.372 -37.268 1.00 26.96 ? 198 ASN A CG 1 ATOM 953 O OD1 . ASN A 1 129 ? 42.912 -2.386 -36.998 1.00 32.96 ? 198 ASN A OD1 1 ATOM 954 N ND2 . ASN A 1 129 ? 42.712 -4.623 -37.233 1.00 28.14 ? 198 ASN A ND2 1 ATOM 955 N N . ASN A 1 130 ? 41.524 -5.443 -40.118 1.00 23.63 ? 199 ASN A N 1 ATOM 956 C CA . ASN A 1 130 ? 42.229 -5.585 -41.396 1.00 23.30 ? 199 ASN A CA 1 ATOM 957 C C . ASN A 1 130 ? 42.409 -7.073 -41.741 1.00 22.38 ? 199 ASN A C 1 ATOM 958 O O . ASN A 1 130 ? 43.523 -7.586 -41.856 1.00 22.28 ? 199 ASN A O 1 ATOM 959 C CB . ASN A 1 130 ? 43.557 -4.836 -41.327 1.00 23.77 ? 199 ASN A CB 1 ATOM 960 C CG . ASN A 1 130 ? 43.976 -4.243 -42.662 1.00 25.27 ? 199 ASN A CG 1 ATOM 961 O OD1 . ASN A 1 130 ? 43.271 -4.357 -43.667 1.00 29.70 ? 199 ASN A OD1 1 ATOM 962 N ND2 . ASN A 1 130 ? 45.148 -3.613 -42.679 1.00 27.91 ? 199 ASN A ND2 1 ATOM 963 N N . ALA A 1 131 ? 41.273 -7.744 -41.891 1.00 20.98 ? 200 ALA A N 1 ATOM 964 C CA . ALA A 1 131 ? 41.230 -9.145 -42.198 1.00 20.68 ? 200 ALA A CA 1 ATOM 965 C C . ALA A 1 131 ? 41.311 -9.366 -43.717 1.00 20.36 ? 200 ALA A C 1 ATOM 966 O O . ALA A 1 131 ? 41.224 -8.419 -44.526 1.00 20.98 ? 200 ALA A O 1 ATOM 967 C CB . ALA A 1 131 ? 39.965 -9.773 -41.601 1.00 20.76 ? 200 ALA A CB 1 ATOM 968 N N . LEU A 1 132 ? 41.493 -10.628 -44.092 1.00 19.86 ? 201 LEU A N 1 ATOM 969 C CA . LEU A 1 132 ? 41.997 -10.999 -45.416 1.00 19.33 ? 201 LEU A CA 1 ATOM 970 C C . LEU A 1 132 ? 41.387 -12.276 -45.946 1.00 18.98 ? 201 LEU A C 1 ATOM 971 O O . LEU A 1 132 ? 41.546 -13.336 -45.342 1.00 18.12 ? 201 LEU A O 1 ATOM 972 C CB . LEU A 1 132 ? 43.511 -11.224 -45.358 1.00 19.35 ? 201 LEU A CB 1 ATOM 973 C CG . LEU A 1 132 ? 44.144 -11.401 -46.752 1.00 18.52 ? 201 LEU A CG 1 ATOM 974 C CD1 . LEU A 1 132 ? 44.280 -10.095 -47.420 1.00 17.72 ? 201 LEU A CD1 1 ATOM 975 C CD2 . LEU A 1 132 ? 45.490 -12.102 -46.699 1.00 18.06 ? 201 LEU A CD2 1 ATOM 976 N N . LEU A 1 133 ? 40.738 -12.166 -47.106 1.00 18.75 ? 202 LEU A N 1 ATOM 977 C CA . LEU A 1 133 ? 40.182 -13.324 -47.813 1.00 18.57 ? 202 LEU A CA 1 ATOM 978 C C . LEU A 1 133 ? 41.266 -13.931 -48.689 1.00 18.06 ? 202 LEU A C 1 ATOM 979 O O . LEU A 1 133 ? 41.926 -13.218 -49.428 1.00 18.24 ? 202 LEU A O 1 ATOM 980 C CB . LEU A 1 133 ? 38.960 -12.934 -48.665 1.00 18.63 ? 202 LEU A CB 1 ATOM 981 C CG . LEU A 1 133 ? 38.188 -14.082 -49.326 1.00 17.23 ? 202 LEU A CG 1 ATOM 982 C CD1 . LEU A 1 133 ? 36.719 -13.769 -49.473 1.00 17.96 ? 202 LEU A CD1 1 ATOM 983 C CD2 . LEU A 1 133 ? 38.777 -14.414 -50.672 1.00 18.48 ? 202 LEU A CD2 1 ATOM 984 N N . LYS A 1 134 ? 41.427 -15.252 -48.583 1.00 18.19 ? 203 LYS A N 1 ATOM 985 C CA . LYS A 1 134 ? 42.525 -15.994 -49.198 1.00 18.05 ? 203 LYS A CA 1 ATOM 986 C C . LYS A 1 134 ? 41.896 -17.085 -50.032 1.00 18.51 ? 203 LYS A C 1 ATOM 987 O O . LYS A 1 134 ? 40.921 -17.686 -49.594 1.00 18.37 ? 203 LYS A O 1 ATOM 988 C CB . LYS A 1 134 ? 43.432 -16.594 -48.122 1.00 17.81 ? 203 LYS A CB 1 ATOM 989 C CG . LYS A 1 134 ? 44.128 -15.554 -47.243 1.00 17.83 ? 203 LYS A CG 1 ATOM 990 C CD . LYS A 1 134 ? 45.256 -16.150 -46.372 1.00 17.42 ? 203 LYS A CD 1 ATOM 991 C CE . LYS A 1 134 ? 44.752 -17.147 -45.320 1.00 19.14 ? 203 LYS A CE 1 ATOM 992 N NZ . LYS A 1 134 ? 43.546 -16.694 -44.597 1.00 17.68 ? 203 LYS A NZ 1 ATOM 993 N N . ILE A 1 135 ? 42.436 -17.298 -51.242 1.00 19.31 ? 204 ILE A N 1 ATOM 994 C CA . ILE A 1 135 ? 41.921 -18.278 -52.208 1.00 19.06 ? 204 ILE A CA 1 ATOM 995 C C . ILE A 1 135 ? 43.016 -19.301 -52.551 1.00 19.30 ? 204 ILE A C 1 ATOM 996 O O . ILE A 1 135 ? 44.121 -18.931 -52.932 1.00 19.27 ? 204 ILE A O 1 ATOM 997 C CB . ILE A 1 135 ? 41.431 -17.595 -53.515 1.00 19.66 ? 204 ILE A CB 1 ATOM 998 C CG1 . ILE A 1 135 ? 40.329 -16.588 -53.201 1.00 20.39 ? 204 ILE A CG1 1 ATOM 999 C CG2 . ILE A 1 135 ? 40.895 -18.636 -54.531 1.00 18.23 ? 204 ILE A CG2 1 ATOM 1000 C CD1 . ILE A 1 135 ? 40.004 -15.689 -54.356 1.00 21.39 ? 204 ILE A CD1 1 ATOM 1001 N N . LYS A 1 136 ? 42.680 -20.586 -52.404 1.00 19.79 ? 205 LYS A N 1 ATOM 1002 C CA . LYS A 1 136 ? 43.518 -21.719 -52.793 1.00 19.94 ? 205 LYS A CA 1 ATOM 1003 C C . LYS A 1 136 ? 42.802 -22.422 -53.965 1.00 19.86 ? 205 LYS A C 1 ATOM 1004 O O . LYS A 1 136 ? 41.641 -22.782 -53.819 1.00 20.61 ? 205 LYS A O 1 ATOM 1005 C CB . LYS A 1 136 ? 43.663 -22.636 -51.558 1.00 20.01 ? 205 LYS A CB 1 ATOM 1006 C CG . LYS A 1 136 ? 44.565 -23.882 -51.652 1.00 21.54 ? 205 LYS A CG 1 ATOM 1007 C CD . LYS A 1 136 ? 44.950 -24.406 -50.243 1.00 22.62 ? 205 LYS A CD 1 ATOM 1008 C CE . LYS A 1 136 ? 45.374 -25.869 -50.206 1.00 24.32 ? 205 LYS A CE 1 ATOM 1009 N NZ . LYS A 1 136 ? 44.228 -26.896 -50.155 1.00 26.21 ? 205 LYS A NZ 1 ATOM 1010 N N . TYR A 1 137 ? 43.448 -22.555 -55.132 1.00 19.44 ? 206 TYR A N 1 ATOM 1011 C CA . TYR A 1 137 ? 42.934 -23.391 -56.245 1.00 19.31 ? 206 TYR A CA 1 ATOM 1012 C C . TYR A 1 137 ? 43.769 -24.669 -56.324 1.00 20.09 ? 206 TYR A C 1 ATOM 1013 O O . TYR A 1 137 ? 44.946 -24.623 -56.694 1.00 19.32 ? 206 TYR A O 1 ATOM 1014 C CB . TYR A 1 137 ? 42.999 -22.640 -57.567 1.00 19.10 ? 206 TYR A CB 1 ATOM 1015 C CG . TYR A 1 137 ? 42.269 -23.281 -58.732 1.00 18.81 ? 206 TYR A CG 1 ATOM 1016 C CD1 . TYR A 1 137 ? 40.891 -23.435 -58.724 1.00 20.04 ? 206 TYR A CD1 1 ATOM 1017 C CD2 . TYR A 1 137 ? 42.949 -23.676 -59.875 1.00 17.31 ? 206 TYR A CD2 1 ATOM 1018 C CE1 . TYR A 1 137 ? 40.210 -24.002 -59.823 1.00 18.16 ? 206 TYR A CE1 1 ATOM 1019 C CE2 . TYR A 1 137 ? 42.280 -24.223 -60.955 1.00 16.20 ? 206 TYR A CE2 1 ATOM 1020 C CZ . TYR A 1 137 ? 40.919 -24.394 -60.931 1.00 17.45 ? 206 TYR A CZ 1 ATOM 1021 O OH . TYR A 1 137 ? 40.268 -24.937 -62.048 1.00 17.22 ? 206 TYR A OH 1 ATOM 1022 N N . GLY A 1 138 ? 43.173 -25.801 -55.925 1.00 21.03 ? 207 GLY A N 1 ATOM 1023 C CA . GLY A 1 138 ? 43.917 -27.058 -55.716 1.00 21.68 ? 207 GLY A CA 1 ATOM 1024 C C . GLY A 1 138 ? 44.929 -26.963 -54.574 1.00 22.26 ? 207 GLY A C 1 ATOM 1025 O O . GLY A 1 138 ? 44.561 -26.630 -53.452 1.00 23.37 ? 207 GLY A O 1 ATOM 1026 N N . GLU A 1 139 ? 46.204 -27.253 -54.858 1.00 22.61 ? 208 GLU A N 1 ATOM 1027 C CA . GLU A 1 139 ? 47.284 -27.010 -53.903 1.00 23.32 ? 208 GLU A CA 1 ATOM 1028 C C . GLU A 1 139 ? 47.747 -25.541 -53.834 1.00 23.03 ? 208 GLU A C 1 ATOM 1029 O O . GLU A 1 139 ? 48.282 -25.130 -52.794 1.00 22.38 ? 208 GLU A O 1 ATOM 1030 C CB . GLU A 1 139 ? 48.514 -27.859 -54.205 1.00 23.71 ? 208 GLU A CB 1 ATOM 1031 C CG . GLU A 1 139 ? 48.281 -29.342 -54.290 1.00 27.08 ? 208 GLU A CG 1 ATOM 1032 C CD . GLU A 1 139 ? 47.796 -29.950 -52.989 1.00 30.69 ? 208 GLU A CD 1 ATOM 1033 O OE1 . GLU A 1 139 ? 48.556 -29.893 -51.984 1.00 35.10 ? 208 GLU A OE1 1 ATOM 1034 O OE2 . GLU A 1 139 ? 46.660 -30.498 -52.988 1.00 32.23 ? 208 GLU A OE2 1 ATOM 1035 N N . ALA A 1 140 ? 47.557 -24.762 -54.916 1.00 22.21 ? 209 ALA A N 1 ATOM 1036 C CA . ALA A 1 140 ? 48.183 -23.427 -55.024 1.00 22.01 ? 209 ALA A CA 1 ATOM 1037 C C . ALA A 1 140 ? 47.372 -22.308 -54.373 1.00 21.95 ? 209 ALA A C 1 ATOM 1038 O O . ALA A 1 140 ? 46.199 -22.164 -54.648 1.00 22.47 ? 209 ALA A O 1 ATOM 1039 C CB . ALA A 1 140 ? 48.473 -23.080 -56.510 1.00 21.87 ? 209 ALA A CB 1 ATOM 1040 N N . TYR A 1 141 ? 47.990 -21.517 -53.504 1.00 21.78 ? 210 TYR A N 1 ATOM 1041 C CA . TYR A 1 141 ? 47.364 -20.282 -53.033 1.00 21.69 ? 210 TYR A CA 1 ATOM 1042 C C . TYR A 1 141 ? 47.516 -19.313 -54.209 1.00 21.38 ? 210 TYR A C 1 ATOM 1043 O O . TYR A 1 141 ? 48.604 -19.173 -54.773 1.00 20.78 ? 210 TYR A O 1 ATOM 1044 C CB . TYR A 1 141 ? 48.022 -19.776 -51.746 1.00 22.31 ? 210 TYR A CB 1 ATOM 1045 C CG . TYR A 1 141 ? 47.921 -20.759 -50.584 1.00 23.35 ? 210 TYR A CG 1 ATOM 1046 C CD1 . TYR A 1 141 ? 46.817 -20.775 -49.751 1.00 24.85 ? 210 TYR A CD1 1 ATOM 1047 C CD2 . TYR A 1 141 ? 48.929 -21.678 -50.339 1.00 25.44 ? 210 TYR A CD2 1 ATOM 1048 C CE1 . TYR A 1 141 ? 46.719 -21.675 -48.690 1.00 25.61 ? 210 TYR A CE1 1 ATOM 1049 C CE2 . TYR A 1 141 ? 48.836 -22.592 -49.291 1.00 26.59 ? 210 TYR A CE2 1 ATOM 1050 C CZ . TYR A 1 141 ? 47.725 -22.583 -48.461 1.00 26.78 ? 210 TYR A CZ 1 ATOM 1051 O OH . TYR A 1 141 ? 47.624 -23.495 -47.409 1.00 26.74 ? 210 TYR A OH 1 ATOM 1052 N N . THR A 1 142 ? 46.427 -18.670 -54.610 1.00 20.87 ? 211 THR A N 1 ATOM 1053 C CA A THR A 1 142 ? 46.408 -18.007 -55.900 0.50 20.59 ? 211 THR A CA 1 ATOM 1054 C CA B THR A 1 142 ? 46.372 -17.998 -55.921 0.50 20.40 ? 211 THR A CA 1 ATOM 1055 C C . THR A 1 142 ? 45.952 -16.543 -55.889 1.00 20.27 ? 211 THR A C 1 ATOM 1056 O O . THR A 1 142 ? 46.231 -15.805 -56.859 1.00 21.20 ? 211 THR A O 1 ATOM 1057 C CB A THR A 1 142 ? 45.557 -18.840 -56.846 0.50 20.57 ? 211 THR A CB 1 ATOM 1058 C CB B THR A 1 142 ? 45.401 -18.704 -56.881 0.50 20.32 ? 211 THR A CB 1 ATOM 1059 O OG1 A THR A 1 142 ? 45.668 -18.326 -58.168 0.50 21.22 ? 211 THR A OG1 1 ATOM 1060 O OG1 B THR A 1 142 ? 44.128 -18.853 -56.241 0.50 20.08 ? 211 THR A OG1 1 ATOM 1061 C CG2 A THR A 1 142 ? 44.118 -18.836 -56.396 0.50 20.56 ? 211 THR A CG2 1 ATOM 1062 C CG2 B THR A 1 142 ? 45.940 -20.063 -57.301 0.50 20.02 ? 211 THR A CG2 1 ATOM 1063 N N . ASP A 1 143 ? 45.256 -16.121 -54.827 1.00 19.48 ? 212 ASP A N 1 ATOM 1064 C CA . ASP A 1 143 ? 44.819 -14.727 -54.684 1.00 18.89 ? 212 ASP A CA 1 ATOM 1065 C C . ASP A 1 143 ? 44.321 -14.329 -53.265 1.00 18.41 ? 212 ASP A C 1 ATOM 1066 O O . ASP A 1 143 ? 44.175 -15.173 -52.381 1.00 18.40 ? 212 ASP A O 1 ATOM 1067 C CB . ASP A 1 143 ? 43.720 -14.444 -55.703 1.00 19.05 ? 212 ASP A CB 1 ATOM 1068 C CG . ASP A 1 143 ? 43.714 -13.008 -56.178 1.00 18.85 ? 212 ASP A CG 1 ATOM 1069 O OD1 . ASP A 1 143 ? 44.569 -12.217 -55.748 1.00 20.61 ? 212 ASP A OD1 1 ATOM 1070 O OD2 . ASP A 1 143 ? 42.848 -12.664 -56.996 1.00 19.97 ? 212 ASP A OD2 1 ATOM 1071 N N . THR A 1 144 ? 44.089 -13.034 -53.064 1.00 18.51 ? 213 THR A N 1 ATOM 1072 C CA . THR A 1 144 ? 43.418 -12.528 -51.873 1.00 19.46 ? 213 THR A CA 1 ATOM 1073 C C . THR A 1 144 ? 42.554 -11.312 -52.148 1.00 19.84 ? 213 THR A C 1 ATOM 1074 O O . THR A 1 144 ? 42.563 -10.738 -53.271 1.00 19.49 ? 213 THR A O 1 ATOM 1075 C CB . THR A 1 144 ? 44.398 -12.066 -50.789 1.00 19.71 ? 213 THR A CB 1 ATOM 1076 O OG1 . THR A 1 144 ? 45.121 -10.935 -51.296 1.00 20.24 ? 213 THR A OG1 1 ATOM 1077 C CG2 . THR A 1 144 ? 45.335 -13.183 -50.372 1.00 18.57 ? 213 THR A CG2 1 ATOM 1078 N N . TYR A 1 145 ? 41.844 -10.906 -51.090 1.00 19.75 ? 214 TYR A N 1 ATOM 1079 C CA . TYR A 1 145 ? 40.967 -9.744 -51.140 1.00 20.14 ? 214 TYR A CA 1 ATOM 1080 C C . TYR A 1 145 ? 40.934 -9.046 -49.788 1.00 20.47 ? 214 TYR A C 1 ATOM 1081 O O . TYR A 1 145 ? 40.766 -9.679 -48.745 1.00 20.31 ? 214 TYR A O 1 ATOM 1082 C CB . TYR A 1 145 ? 39.553 -10.150 -51.574 1.00 20.22 ? 214 TYR A CB 1 ATOM 1083 C CG . TYR A 1 145 ? 38.721 -8.986 -52.024 1.00 19.97 ? 214 TYR A CG 1 ATOM 1084 C CD1 . TYR A 1 145 ? 38.862 -8.465 -53.306 1.00 21.41 ? 214 TYR A CD1 1 ATOM 1085 C CD2 . TYR A 1 145 ? 37.801 -8.388 -51.170 1.00 20.03 ? 214 TYR A CD2 1 ATOM 1086 C CE1 . TYR A 1 145 ? 38.089 -7.373 -53.739 1.00 20.58 ? 214 TYR A CE1 1 ATOM 1087 C CE2 . TYR A 1 145 ? 37.024 -7.307 -51.589 1.00 19.82 ? 214 TYR A CE2 1 ATOM 1088 C CZ . TYR A 1 145 ? 37.180 -6.798 -52.877 1.00 19.76 ? 214 TYR A CZ 1 ATOM 1089 O OH . TYR A 1 145 ? 36.427 -5.727 -53.304 1.00 18.02 ? 214 TYR A OH 1 ATOM 1090 N N . HIS A 1 146 ? 41.101 -7.725 -49.824 1.00 21.01 ? 215 HIS A N 1 ATOM 1091 C CA . HIS A 1 146 ? 41.282 -6.937 -48.610 1.00 20.53 ? 215 HIS A CA 1 ATOM 1092 C C . HIS A 1 146 ? 39.968 -6.404 -48.056 1.00 20.27 ? 215 HIS A C 1 ATOM 1093 O O . HIS A 1 146 ? 39.025 -6.128 -48.803 1.00 19.79 ? 215 HIS A O 1 ATOM 1094 C CB . HIS A 1 146 ? 42.277 -5.804 -48.878 1.00 20.75 ? 215 HIS A CB 1 ATOM 1095 C CG . HIS A 1 146 ? 43.702 -6.262 -48.871 1.00 22.17 ? 215 HIS A CG 1 ATOM 1096 N ND1 . HIS A 1 146 ? 44.391 -6.515 -47.701 1.00 21.60 ? 215 HIS A ND1 1 ATOM 1097 C CD2 . HIS A 1 146 ? 44.560 -6.539 -49.886 1.00 22.44 ? 215 HIS A CD2 1 ATOM 1098 C CE1 . HIS A 1 146 ? 45.615 -6.925 -47.996 1.00 22.84 ? 215 HIS A CE1 1 ATOM 1099 N NE2 . HIS A 1 146 ? 45.740 -6.952 -49.313 1.00 24.06 ? 215 HIS A NE2 1 ATOM 1100 N N . SER A 1 147 ? 39.939 -6.304 -46.724 1.00 20.19 ? 216 SER A N 1 ATOM 1101 C CA . SER A 1 147 ? 38.858 -5.742 -45.936 1.00 19.56 ? 216 SER A CA 1 ATOM 1102 C C . SER A 1 147 ? 38.597 -4.332 -46.414 1.00 19.68 ? 216 SER A C 1 ATOM 1103 O O . SER A 1 147 ? 39.529 -3.552 -46.532 1.00 20.86 ? 216 SER A O 1 ATOM 1104 C CB . SER A 1 147 ? 39.279 -5.762 -44.445 1.00 19.82 ? 216 SER A CB 1 ATOM 1105 O OG . SER A 1 147 ? 38.415 -5.025 -43.597 1.00 19.35 ? 216 SER A OG 1 ATOM 1106 N N . TYR A 1 148 ? 37.337 -4.015 -46.713 1.00 18.97 ? 217 TYR A N 1 ATOM 1107 C CA . TYR A 1 148 ? 36.953 -2.713 -47.304 1.00 18.19 ? 217 TYR A CA 1 ATOM 1108 C C . TYR A 1 148 ? 36.136 -1.846 -46.357 1.00 18.57 ? 217 TYR A C 1 ATOM 1109 O O . TYR A 1 148 ? 35.810 -0.701 -46.695 1.00 18.67 ? 217 TYR A O 1 ATOM 1110 C CB . TYR A 1 148 ? 36.143 -2.894 -48.599 1.00 17.45 ? 217 TYR A CB 1 ATOM 1111 C CG . TYR A 1 148 ? 34.902 -3.760 -48.469 1.00 14.18 ? 217 TYR A CG 1 ATOM 1112 C CD1 . TYR A 1 148 ? 33.636 -3.207 -48.395 1.00 11.57 ? 217 TYR A CD1 1 ATOM 1113 C CD2 . TYR A 1 148 ? 35.003 -5.141 -48.493 1.00 13.24 ? 217 TYR A CD2 1 ATOM 1114 C CE1 . TYR A 1 148 ? 32.487 -4.029 -48.316 1.00 10.46 ? 217 TYR A CE1 1 ATOM 1115 C CE2 . TYR A 1 148 ? 33.885 -5.961 -48.408 1.00 10.99 ? 217 TYR A CE2 1 ATOM 1116 C CZ . TYR A 1 148 ? 32.632 -5.416 -48.314 1.00 10.95 ? 217 TYR A CZ 1 ATOM 1117 O OH . TYR A 1 148 ? 31.550 -6.272 -48.212 1.00 7.13 ? 217 TYR A OH 1 ATOM 1118 N N . ALA A 1 149 ? 35.793 -2.393 -45.193 1.00 18.48 ? 218 ALA A N 1 ATOM 1119 C CA . ALA A 1 149 ? 35.093 -1.647 -44.162 1.00 18.29 ? 218 ALA A CA 1 ATOM 1120 C C . ALA A 1 149 ? 35.783 -1.843 -42.836 1.00 18.66 ? 218 ALA A C 1 ATOM 1121 O O . ALA A 1 149 ? 35.304 -1.359 -41.805 1.00 19.42 ? 218 ALA A O 1 ATOM 1122 C CB . ALA A 1 149 ? 33.646 -2.098 -44.072 1.00 18.19 ? 218 ALA A CB 1 ATOM 1123 N N . ASN A 1 150 ? 36.894 -2.568 -42.839 1.00 18.39 ? 219 ASN A N 1 ATOM 1124 C CA . ASN A 1 150 ? 37.715 -2.660 -41.642 1.00 18.39 ? 219 ASN A CA 1 ATOM 1125 C C . ASN A 1 150 ? 36.935 -3.090 -40.393 1.00 17.81 ? 219 ASN A C 1 ATOM 1126 O O . ASN A 1 150 ? 37.179 -2.588 -39.303 1.00 17.63 ? 219 ASN A O 1 ATOM 1127 C CB . ASN A 1 150 ? 38.408 -1.317 -41.391 1.00 18.84 ? 219 ASN A CB 1 ATOM 1128 C CG . ASN A 1 150 ? 39.316 -0.897 -42.530 1.00 18.44 ? 219 ASN A CG 1 ATOM 1129 O OD1 . ASN A 1 150 ? 39.135 0.164 -43.078 1.00 21.08 ? 219 ASN A OD1 1 ATOM 1130 N ND2 . ASN A 1 150 ? 40.323 -1.720 -42.859 1.00 19.49 ? 219 ASN A ND2 1 ATOM 1131 N N . ASN A 1 151 ? 35.988 -4.014 -40.567 1.00 17.73 ? 220 ASN A N 1 ATOM 1132 C CA . ASN A 1 151 ? 35.227 -4.564 -39.450 1.00 17.05 ? 220 ASN A CA 1 ATOM 1133 C C . ASN A 1 151 ? 34.746 -5.984 -39.716 1.00 16.32 ? 220 ASN A C 1 ATOM 1134 O O . ASN A 1 151 ? 33.570 -6.232 -39.920 1.00 15.88 ? 220 ASN A O 1 ATOM 1135 C CB . ASN A 1 151 ? 34.074 -3.632 -39.075 1.00 18.14 ? 220 ASN A CB 1 ATOM 1136 C CG . ASN A 1 151 ? 33.567 -3.841 -37.622 1.00 19.33 ? 220 ASN A CG 1 ATOM 1137 O OD1 . ASN A 1 151 ? 33.815 -4.864 -36.988 1.00 22.32 ? 220 ASN A OD1 1 ATOM 1138 N ND2 . ASN A 1 151 ? 32.827 -2.867 -37.125 1.00 21.51 ? 220 ASN A ND2 1 ATOM 1139 N N . ILE A 1 152 ? 35.709 -6.907 -39.689 1.00 16.04 ? 221 ILE A N 1 ATOM 1140 C CA . ILE A 1 152 ? 35.499 -8.355 -39.652 1.00 15.37 ? 221 ILE A CA 1 ATOM 1141 C C . ILE A 1 152 ? 35.024 -8.793 -41.032 1.00 15.57 ? 221 ILE A C 1 ATOM 1142 O O . ILE A 1 152 ? 33.902 -9.253 -41.213 1.00 16.14 ? 221 ILE A O 1 ATOM 1143 C CB . ILE A 1 152 ? 34.564 -8.825 -38.449 1.00 14.88 ? 221 ILE A CB 1 ATOM 1144 C CG1 . ILE A 1 152 ? 35.035 -8.216 -37.113 1.00 15.72 ? 221 ILE A CG1 1 ATOM 1145 C CG2 . ILE A 1 152 ? 34.607 -10.309 -38.280 1.00 13.47 ? 221 ILE A CG2 1 ATOM 1146 C CD1 . ILE A 1 152 ? 34.219 -8.672 -35.846 1.00 12.85 ? 221 ILE A CD1 1 ATOM 1147 N N . LEU A 1 153 ? 35.875 -8.594 -42.029 1.00 15.74 ? 222 LEU A N 1 ATOM 1148 C CA . LEU A 1 153 ? 35.590 -9.110 -43.360 1.00 15.64 ? 222 LEU A CA 1 ATOM 1149 C C . LEU A 1 153 ? 35.276 -10.608 -43.236 1.00 16.23 ? 222 LEU A C 1 ATOM 1150 O O . LEU A 1 153 ? 35.913 -11.345 -42.467 1.00 17.40 ? 222 LEU A O 1 ATOM 1151 C CB . LEU A 1 153 ? 36.769 -8.878 -44.284 1.00 15.23 ? 222 LEU A CB 1 ATOM 1152 C CG . LEU A 1 153 ? 36.717 -9.443 -45.699 1.00 13.67 ? 222 LEU A CG 1 ATOM 1153 C CD1 . LEU A 1 153 ? 35.796 -8.639 -46.582 1.00 12.25 ? 222 LEU A CD1 1 ATOM 1154 C CD2 . LEU A 1 153 ? 38.113 -9.446 -46.204 1.00 12.83 ? 222 LEU A CD2 1 ATOM 1155 N N . ARG A 1 154 ? 34.305 -11.043 -44.009 1.00 16.48 ? 223 ARG A N 1 ATOM 1156 C CA . ARG A 1 154 ? 33.599 -12.289 -43.759 1.00 17.40 ? 223 ARG A CA 1 ATOM 1157 C C . ARG A 1 154 ? 33.083 -12.907 -45.054 1.00 17.35 ? 223 ARG A C 1 ATOM 1158 O O . ARG A 1 154 ? 32.866 -12.192 -46.020 1.00 17.93 ? 223 ARG A O 1 ATOM 1159 C CB . ARG A 1 154 ? 32.386 -11.963 -42.895 1.00 17.27 ? 223 ARG A CB 1 ATOM 1160 C CG . ARG A 1 154 ? 32.508 -12.391 -41.509 1.00 17.81 ? 223 ARG A CG 1 ATOM 1161 C CD . ARG A 1 154 ? 32.022 -11.317 -40.548 1.00 17.36 ? 223 ARG A CD 1 ATOM 1162 N NE . ARG A 1 154 ? 30.661 -10.816 -40.728 1.00 15.97 ? 223 ARG A NE 1 ATOM 1163 C CZ . ARG A 1 154 ? 30.322 -9.525 -40.854 1.00 15.71 ? 223 ARG A CZ 1 ATOM 1164 N NH1 . ARG A 1 154 ? 31.245 -8.553 -40.923 1.00 16.76 ? 223 ARG A NH1 1 ATOM 1165 N NH2 . ARG A 1 154 ? 29.045 -9.195 -40.940 1.00 14.40 ? 223 ARG A NH2 1 ATOM 1166 N N . THR A 1 155 ? 32.828 -14.213 -45.044 1.00 17.82 ? 224 THR A N 1 ATOM 1167 C CA . THR A 1 155 ? 32.206 -14.882 -46.201 1.00 18.05 ? 224 THR A CA 1 ATOM 1168 C C . THR A 1 155 ? 31.116 -15.822 -45.718 1.00 18.62 ? 224 THR A C 1 ATOM 1169 O O . THR A 1 155 ? 30.664 -15.714 -44.568 1.00 19.45 ? 224 THR A O 1 ATOM 1170 C CB . THR A 1 155 ? 33.261 -15.587 -47.143 1.00 17.83 ? 224 THR A CB 1 ATOM 1171 O OG1 . THR A 1 155 ? 32.623 -16.047 -48.347 1.00 18.57 ? 224 THR A OG1 1 ATOM 1172 C CG2 . THR A 1 155 ? 33.992 -16.724 -46.442 1.00 14.82 ? 224 THR A CG2 1 ATOM 1173 N N . GLN A 1 156 ? 30.722 -16.745 -46.592 1.00 18.61 ? 225 GLN A N 1 ATOM 1174 C CA . GLN A 1 156 ? 29.430 -17.404 -46.522 1.00 18.31 ? 225 GLN A CA 1 ATOM 1175 C C . GLN A 1 156 ? 29.291 -18.513 -45.500 1.00 17.72 ? 225 GLN A C 1 ATOM 1176 O O . GLN A 1 156 ? 28.182 -18.725 -45.039 1.00 17.60 ? 225 GLN A O 1 ATOM 1177 C CB . GLN A 1 156 ? 29.062 -18.049 -47.878 1.00 18.02 ? 225 GLN A CB 1 ATOM 1178 C CG . GLN A 1 156 ? 28.972 -17.130 -49.060 1.00 19.80 ? 225 GLN A CG 1 ATOM 1179 C CD . GLN A 1 156 ? 28.665 -17.877 -50.368 1.00 20.65 ? 225 GLN A CD 1 ATOM 1180 O OE1 . GLN A 1 156 ? 28.213 -19.010 -50.353 1.00 25.49 ? 225 GLN A OE1 1 ATOM 1181 N NE2 . GLN A 1 156 ? 28.928 -17.251 -51.480 1.00 20.64 ? 225 GLN A NE2 1 ATOM 1182 N N . GLU A 1 157 ? 30.373 -19.251 -45.201 1.00 17.47 ? 226 GLU A N 1 ATOM 1183 C CA A GLU A 1 157 ? 30.316 -20.548 -44.465 0.60 17.49 ? 226 GLU A CA 1 ATOM 1184 C CA B GLU A 1 157 ? 30.272 -20.496 -44.419 0.40 16.75 ? 226 GLU A CA 1 ATOM 1185 C C . GLU A 1 157 ? 29.403 -21.563 -45.132 1.00 16.90 ? 226 GLU A C 1 ATOM 1186 O O . GLU A 1 157 ? 28.759 -22.401 -44.469 1.00 16.39 ? 226 GLU A O 1 ATOM 1187 C CB A GLU A 1 157 ? 29.967 -20.409 -42.982 0.60 17.95 ? 226 GLU A CB 1 ATOM 1188 C CB B GLU A 1 157 ? 29.750 -20.221 -42.998 0.40 16.59 ? 226 GLU A CB 1 ATOM 1189 C CG A GLU A 1 157 ? 31.082 -19.756 -42.156 0.60 19.14 ? 226 GLU A CG 1 ATOM 1190 C CG B GLU A 1 157 ? 30.246 -18.913 -42.337 0.40 14.91 ? 226 GLU A CG 1 ATOM 1191 C CD A GLU A 1 157 ? 30.906 -18.273 -42.056 0.60 20.37 ? 226 GLU A CD 1 ATOM 1192 C CD B GLU A 1 157 ? 31.762 -18.864 -42.050 0.40 12.58 ? 226 GLU A CD 1 ATOM 1193 O OE1 A GLU A 1 157 ? 29.831 -17.805 -42.495 0.60 21.09 ? 226 GLU A OE1 1 ATOM 1194 O OE1 B GLU A 1 157 ? 32.518 -19.786 -42.439 0.40 9.18 ? 226 GLU A OE1 1 ATOM 1195 O OE2 A GLU A 1 157 ? 31.826 -17.585 -41.542 0.60 19.63 ? 226 GLU A OE2 1 ATOM 1196 O OE2 B GLU A 1 157 ? 32.196 -17.869 -41.423 0.40 10.97 ? 226 GLU A OE2 1 ATOM 1197 N N . SER A 1 158 ? 29.392 -21.514 -46.473 1.00 16.24 ? 227 SER A N 1 ATOM 1198 C CA . SER A 1 158 ? 28.772 -22.524 -47.296 1.00 15.48 ? 227 SER A CA 1 ATOM 1199 C C . SER A 1 158 ? 29.344 -22.470 -48.731 1.00 15.64 ? 227 SER A C 1 ATOM 1200 O O . SER A 1 158 ? 30.162 -21.627 -49.059 1.00 16.60 ? 227 SER A O 1 ATOM 1201 C CB . SER A 1 158 ? 27.245 -22.417 -47.265 1.00 15.85 ? 227 SER A CB 1 ATOM 1202 O OG . SER A 1 158 ? 26.735 -21.163 -47.688 1.00 15.53 ? 227 SER A OG 1 ATOM 1203 N N . ALA A 1 159 ? 28.947 -23.418 -49.560 1.00 15.86 ? 228 ALA A N 1 ATOM 1204 C CA . ALA A 1 159 ? 29.555 -23.642 -50.870 1.00 15.79 ? 228 ALA A CA 1 ATOM 1205 C C . ALA A 1 159 ? 29.435 -22.418 -51.755 1.00 15.58 ? 228 ALA A C 1 ATOM 1206 O O . ALA A 1 159 ? 28.417 -21.734 -51.717 1.00 16.82 ? 228 ALA A O 1 ATOM 1207 C CB . ALA A 1 159 ? 28.894 -24.863 -51.557 1.00 15.05 ? 228 ALA A CB 1 ATOM 1208 N N . CYS A 1 160 ? 30.473 -22.134 -52.527 1.00 15.50 ? 229 CYS A N 1 ATOM 1209 C CA . CYS A 1 160 ? 30.381 -21.171 -53.608 1.00 16.60 ? 229 CYS A CA 1 ATOM 1210 C C . CYS A 1 160 ? 29.797 -21.913 -54.817 1.00 16.96 ? 229 CYS A C 1 ATOM 1211 O O . CYS A 1 160 ? 29.560 -23.129 -54.745 1.00 16.97 ? 229 CYS A O 1 ATOM 1212 C CB . CYS A 1 160 ? 31.738 -20.485 -53.932 1.00 16.60 ? 229 CYS A CB 1 ATOM 1213 S SG . CYS A 1 160 ? 33.206 -21.464 -53.756 1.00 19.87 ? 229 CYS A SG 1 ATOM 1214 N N . ASN A 1 161 ? 29.545 -21.189 -55.905 1.00 16.62 ? 230 ASN A N 1 ATOM 1215 C CA . ASN A 1 161 ? 28.828 -21.759 -57.048 1.00 17.48 ? 230 ASN A CA 1 ATOM 1216 C C . ASN A 1 161 ? 29.507 -21.428 -58.378 1.00 17.37 ? 230 ASN A C 1 ATOM 1217 O O . ASN A 1 161 ? 29.678 -20.270 -58.727 1.00 17.39 ? 230 ASN A O 1 ATOM 1218 C CB . ASN A 1 161 ? 27.402 -21.214 -57.070 1.00 17.30 ? 230 ASN A CB 1 ATOM 1219 C CG . ASN A 1 161 ? 26.571 -21.699 -55.908 1.00 18.57 ? 230 ASN A CG 1 ATOM 1220 O OD1 . ASN A 1 161 ? 25.817 -22.670 -56.043 1.00 19.77 ? 230 ASN A OD1 1 ATOM 1221 N ND2 . ASN A 1 161 ? 26.693 -21.024 -54.748 1.00 18.39 ? 230 ASN A ND2 1 ATOM 1222 N N . CYS A 1 162 ? 29.877 -22.446 -59.125 1.00 17.57 ? 231 CYS A N 1 ATOM 1223 C CA . CYS A 1 162 ? 30.642 -22.245 -60.346 1.00 18.28 ? 231 CYS A CA 1 ATOM 1224 C C . CYS A 1 162 ? 29.825 -22.576 -61.563 1.00 17.88 ? 231 CYS A C 1 ATOM 1225 O O . CYS A 1 162 ? 29.010 -23.480 -61.527 1.00 18.24 ? 231 CYS A O 1 ATOM 1226 C CB . CYS A 1 162 ? 31.879 -23.147 -60.321 1.00 18.45 ? 231 CYS A CB 1 ATOM 1227 S SG . CYS A 1 162 ? 32.794 -23.024 -58.773 1.00 19.94 ? 231 CYS A SG 1 ATOM 1228 N N . ILE A 1 163 ? 30.088 -21.876 -62.654 1.00 18.44 ? 232 ILE A N 1 ATOM 1229 C CA . ILE A 1 163 ? 29.460 -22.180 -63.941 1.00 18.71 ? 232 ILE A CA 1 ATOM 1230 C C . ILE A 1 163 ? 30.371 -21.787 -65.087 1.00 18.42 ? 232 ILE A C 1 ATOM 1231 O O . ILE A 1 163 ? 30.931 -20.697 -65.091 1.00 17.66 ? 232 ILE A O 1 ATOM 1232 C CB . ILE A 1 163 ? 28.092 -21.452 -64.106 1.00 19.38 ? 232 ILE A CB 1 ATOM 1233 C CG1 . ILE A 1 163 ? 27.411 -21.876 -65.434 1.00 19.94 ? 232 ILE A CG1 1 ATOM 1234 C CG2 . ILE A 1 163 ? 28.271 -19.921 -63.971 1.00 18.45 ? 232 ILE A CG2 1 ATOM 1235 C CD1 . ILE A 1 163 ? 25.976 -21.379 -65.588 1.00 19.34 ? 232 ILE A CD1 1 ATOM 1236 N N . GLY A 1 164 ? 30.497 -22.669 -66.070 1.00 18.68 ? 233 GLY A N 1 ATOM 1237 C CA . GLY A 1 164 ? 31.448 -22.477 -67.156 1.00 19.23 ? 233 GLY A CA 1 ATOM 1238 C C . GLY A 1 164 ? 32.836 -22.045 -66.702 1.00 19.93 ? 233 GLY A C 1 ATOM 1239 O O . GLY A 1 164 ? 33.587 -21.473 -67.497 1.00 19.94 ? 233 GLY A O 1 ATOM 1240 N N . GLY A 1 165 ? 33.156 -22.297 -65.420 1.00 20.34 ? 234 GLY A N 1 ATOM 1241 C CA . GLY A 1 165 ? 34.437 -21.932 -64.820 1.00 20.52 ? 234 GLY A CA 1 ATOM 1242 C C . GLY A 1 165 ? 34.484 -20.683 -63.948 1.00 20.86 ? 234 GLY A C 1 ATOM 1243 O O . GLY A 1 165 ? 35.525 -20.366 -63.384 1.00 21.26 ? 234 GLY A O 1 ATOM 1244 N N . ASN A 1 166 ? 33.398 -19.935 -63.857 1.00 20.91 ? 235 ASN A N 1 ATOM 1245 C CA . ASN A 1 166 ? 33.385 -18.750 -63.010 1.00 21.03 ? 235 ASN A CA 1 ATOM 1246 C C . ASN A 1 166 ? 32.688 -19.122 -61.713 1.00 21.60 ? 235 ASN A C 1 ATOM 1247 O O . ASN A 1 166 ? 31.548 -19.589 -61.755 1.00 21.54 ? 235 ASN A O 1 ATOM 1248 C CB . ASN A 1 166 ? 32.666 -17.623 -63.724 1.00 21.06 ? 235 ASN A CB 1 ATOM 1249 C CG . ASN A 1 166 ? 33.203 -17.413 -65.150 1.00 21.24 ? 235 ASN A CG 1 ATOM 1250 O OD1 . ASN A 1 166 ? 34.398 -17.198 -65.351 1.00 15.32 ? 235 ASN A OD1 1 ATOM 1251 N ND2 . ASN A 1 166 ? 32.316 -17.484 -66.133 1.00 21.83 ? 235 ASN A ND2 1 ATOM 1252 N N . CYS A 1 167 ? 33.382 -18.977 -60.580 1.00 21.66 ? 236 CYS A N 1 ATOM 1253 C CA . CYS A 1 167 ? 32.791 -19.303 -59.267 1.00 22.23 ? 236 CYS A CA 1 ATOM 1254 C C . CYS A 1 167 ? 32.401 -18.055 -58.501 1.00 22.19 ? 236 CYS A C 1 ATOM 1255 O O . CYS A 1 167 ? 33.196 -17.120 -58.363 1.00 22.83 ? 236 CYS A O 1 ATOM 1256 C CB . CYS A 1 167 ? 33.748 -20.143 -58.425 1.00 22.18 ? 236 CYS A CB 1 ATOM 1257 S SG . CYS A 1 167 ? 34.241 -21.676 -59.230 1.00 23.04 ? 236 CYS A SG 1 ATOM 1258 N N . TYR A 1 168 ? 31.171 -18.032 -58.000 1.00 21.98 ? 237 TYR A N 1 ATOM 1259 C CA . TYR A 1 168 ? 30.633 -16.814 -57.416 1.00 21.28 ? 237 TYR A CA 1 ATOM 1260 C C . TYR A 1 168 ? 30.520 -16.902 -55.904 1.00 20.77 ? 237 TYR A C 1 ATOM 1261 O O . TYR A 1 168 ? 30.128 -17.926 -55.347 1.00 20.09 ? 237 TYR A O 1 ATOM 1262 C CB . TYR A 1 168 ? 29.283 -16.503 -58.032 1.00 21.65 ? 237 TYR A CB 1 ATOM 1263 C CG . TYR A 1 168 ? 29.352 -16.037 -59.464 1.00 21.33 ? 237 TYR A CG 1 ATOM 1264 C CD1 . TYR A 1 168 ? 29.337 -14.675 -59.762 1.00 21.20 ? 237 TYR A CD1 1 ATOM 1265 C CD2 . TYR A 1 168 ? 29.419 -16.956 -60.530 1.00 21.74 ? 237 TYR A CD2 1 ATOM 1266 C CE1 . TYR A 1 168 ? 29.369 -14.220 -61.081 1.00 20.28 ? 237 TYR A CE1 1 ATOM 1267 C CE2 . TYR A 1 168 ? 29.453 -16.519 -61.869 1.00 20.75 ? 237 TYR A CE2 1 ATOM 1268 C CZ . TYR A 1 168 ? 29.432 -15.141 -62.136 1.00 21.48 ? 237 TYR A CZ 1 ATOM 1269 O OH . TYR A 1 168 ? 29.474 -14.666 -63.432 1.00 18.22 ? 237 TYR A OH 1 ATOM 1270 N N . LEU A 1 169 ? 30.865 -15.807 -55.241 1.00 20.16 ? 238 LEU A N 1 ATOM 1271 C CA . LEU A 1 169 ? 31.031 -15.818 -53.801 1.00 19.57 ? 238 LEU A CA 1 ATOM 1272 C C . LEU A 1 169 ? 30.615 -14.492 -53.187 1.00 18.96 ? 238 LEU A C 1 ATOM 1273 O O . LEU A 1 169 ? 31.084 -13.456 -53.608 1.00 17.83 ? 238 LEU A O 1 ATOM 1274 C CB . LEU A 1 169 ? 32.499 -16.107 -53.474 1.00 19.83 ? 238 LEU A CB 1 ATOM 1275 C CG . LEU A 1 169 ? 32.907 -16.128 -52.003 1.00 19.90 ? 238 LEU A CG 1 ATOM 1276 C CD1 . LEU A 1 169 ? 32.183 -17.240 -51.318 1.00 21.32 ? 238 LEU A CD1 1 ATOM 1277 C CD2 . LEU A 1 169 ? 34.419 -16.282 -51.846 1.00 20.03 ? 238 LEU A CD2 1 ATOM 1278 N N . MET A 1 170 ? 29.742 -14.552 -52.180 1.00 18.85 ? 239 MET A N 1 ATOM 1279 C CA . MET A 1 170 ? 29.433 -13.404 -51.314 1.00 18.93 ? 239 MET A CA 1 ATOM 1280 C C . MET A 1 170 ? 30.527 -13.216 -50.265 1.00 17.62 ? 239 MET A C 1 ATOM 1281 O O . MET A 1 170 ? 31.053 -14.174 -49.694 1.00 16.98 ? 239 MET A O 1 ATOM 1282 C CB . MET A 1 170 ? 28.068 -13.569 -50.596 1.00 18.75 ? 239 MET A CB 1 ATOM 1283 C CG . MET A 1 170 ? 27.655 -12.371 -49.686 1.00 20.81 ? 239 MET A CG 1 ATOM 1284 S SD . MET A 1 170 ? 27.475 -12.646 -47.851 1.00 22.88 ? 239 MET A SD 1 ATOM 1285 C CE . MET A 1 170 ? 29.024 -13.447 -47.435 1.00 21.16 ? 239 MET A CE 1 ATOM 1286 N N . ILE A 1 171 ? 30.840 -11.951 -50.038 1.00 17.38 ? 240 ILE A N 1 ATOM 1287 C CA . ILE A 1 171 ? 31.590 -11.506 -48.876 1.00 16.55 ? 240 ILE A CA 1 ATOM 1288 C C . ILE A 1 171 ? 30.867 -10.315 -48.269 1.00 16.46 ? 240 ILE A C 1 ATOM 1289 O O . ILE A 1 171 ? 30.018 -9.659 -48.914 1.00 14.68 ? 240 ILE A O 1 ATOM 1290 C CB . ILE A 1 171 ? 33.058 -11.086 -49.230 1.00 16.65 ? 240 ILE A CB 1 ATOM 1291 C CG1 . ILE A 1 171 ? 33.077 -9.928 -50.257 1.00 16.89 ? 240 ILE A CG1 1 ATOM 1292 C CG2 . ILE A 1 171 ? 33.839 -12.290 -49.665 1.00 16.00 ? 240 ILE A CG2 1 ATOM 1293 C CD1 . ILE A 1 171 ? 34.484 -9.523 -50.835 1.00 17.39 ? 240 ILE A CD1 1 ATOM 1294 N N . THR A 1 172 ? 31.229 -10.028 -47.021 1.00 16.44 ? 241 THR A N 1 ATOM 1295 C CA . THR A 1 172 ? 30.681 -8.880 -46.327 1.00 16.40 ? 241 THR A CA 1 ATOM 1296 C C . THR A 1 172 ? 31.657 -8.328 -45.280 1.00 17.09 ? 241 THR A C 1 ATOM 1297 O O . THR A 1 172 ? 32.578 -9.010 -44.835 1.00 16.73 ? 241 THR A O 1 ATOM 1298 C CB . THR A 1 172 ? 29.323 -9.165 -45.725 1.00 15.95 ? 241 THR A CB 1 ATOM 1299 O OG1 . THR A 1 172 ? 28.611 -7.925 -45.625 1.00 15.52 ? 241 THR A OG1 1 ATOM 1300 C CG2 . THR A 1 172 ? 29.439 -9.820 -44.326 1.00 16.21 ? 241 THR A CG2 1 ATOM 1301 N N . ASP A 1 173 ? 31.477 -7.059 -44.954 1.00 17.62 ? 242 ASP A N 1 ATOM 1302 C CA . ASP A 1 173 ? 32.400 -6.375 -44.101 1.00 18.38 ? 242 ASP A CA 1 ATOM 1303 C C . ASP A 1 173 ? 31.595 -5.308 -43.379 1.00 18.94 ? 242 ASP A C 1 ATOM 1304 O O . ASP A 1 173 ? 30.773 -4.651 -43.982 1.00 18.71 ? 242 ASP A O 1 ATOM 1305 C CB . ASP A 1 173 ? 33.553 -5.813 -44.951 1.00 18.35 ? 242 ASP A CB 1 ATOM 1306 C CG . ASP A 1 173 ? 34.764 -5.479 -44.128 1.00 19.30 ? 242 ASP A CG 1 ATOM 1307 O OD1 . ASP A 1 173 ? 34.677 -5.480 -42.864 1.00 22.57 ? 242 ASP A OD1 1 ATOM 1308 O OD2 . ASP A 1 173 ? 35.804 -5.189 -44.730 1.00 18.85 ? 242 ASP A OD2 1 ATOM 1309 N N . GLY A 1 174 ? 31.755 -5.205 -42.065 1.00 20.53 ? 243 GLY A N 1 ATOM 1310 C CA . GLY A 1 174 ? 30.991 -4.222 -41.290 1.00 21.27 ? 243 GLY A CA 1 ATOM 1311 C C . GLY A 1 174 ? 30.603 -4.719 -39.925 1.00 22.47 ? 243 GLY A C 1 ATOM 1312 O O . GLY A 1 174 ? 30.849 -5.863 -39.584 1.00 22.53 ? 243 GLY A O 1 ATOM 1313 N N . SER A 1 175 ? 29.980 -3.847 -39.142 1.00 24.19 ? 244 SER A N 1 ATOM 1314 C CA . SER A 1 175 ? 29.580 -4.182 -37.777 1.00 24.73 ? 244 SER A CA 1 ATOM 1315 C C . SER A 1 175 ? 28.493 -5.222 -37.780 1.00 24.98 ? 244 SER A C 1 ATOM 1316 O O . SER A 1 175 ? 27.495 -5.111 -38.518 1.00 25.06 ? 244 SER A O 1 ATOM 1317 C CB . SER A 1 175 ? 29.042 -2.965 -37.028 1.00 25.02 ? 244 SER A CB 1 ATOM 1318 O OG . SER A 1 175 ? 28.567 -3.353 -35.736 1.00 26.17 ? 244 SER A OG 1 ATOM 1319 N N . ALA A 1 176 ? 28.680 -6.223 -36.927 1.00 25.34 ? 245 ALA A N 1 ATOM 1320 C CA . ALA A 1 176 ? 27.663 -7.235 -36.713 1.00 26.09 ? 245 ALA A CA 1 ATOM 1321 C C . ALA A 1 176 ? 26.355 -6.599 -36.207 1.00 26.75 ? 245 ALA A C 1 ATOM 1322 O O . ALA A 1 176 ? 25.287 -7.192 -36.380 1.00 26.62 ? 245 ALA A O 1 ATOM 1323 C CB . ALA A 1 176 ? 28.163 -8.294 -35.742 1.00 25.99 ? 245 ALA A CB 1 ATOM 1324 N N . SER A 1 177 ? 26.449 -5.390 -35.632 1.00 26.93 ? 246 SER A N 1 ATOM 1325 C CA . SER A 1 177 ? 25.297 -4.679 -35.058 1.00 27.75 ? 246 SER A CA 1 ATOM 1326 C C . SER A 1 177 ? 24.814 -3.488 -35.858 1.00 27.48 ? 246 SER A C 1 ATOM 1327 O O . SER A 1 177 ? 23.924 -2.787 -35.402 1.00 28.27 ? 246 SER A O 1 ATOM 1328 C CB . SER A 1 177 ? 25.632 -4.167 -33.652 1.00 27.66 ? 246 SER A CB 1 ATOM 1329 O OG . SER A 1 177 ? 26.166 -5.214 -32.864 1.00 29.35 ? 246 SER A OG 1 ATOM 1330 N N . GLY A 1 178 ? 25.392 -3.252 -37.029 1.00 26.92 ? 247 GLY A N 1 ATOM 1331 C CA . GLY A 1 178 ? 25.061 -2.092 -37.832 1.00 26.36 ? 247 GLY A CA 1 ATOM 1332 C C . GLY A 1 178 ? 25.136 -2.454 -39.299 1.00 25.95 ? 247 GLY A C 1 ATOM 1333 O O . GLY A 1 178 ? 24.656 -3.508 -39.686 1.00 26.22 ? 247 GLY A O 1 ATOM 1334 N N . ILE A 1 179 ? 25.770 -1.597 -40.096 1.00 25.48 ? 248 ILE A N 1 ATOM 1335 C CA . ILE A 1 179 ? 25.857 -1.777 -41.558 1.00 25.88 ? 248 ILE A CA 1 ATOM 1336 C C . ILE A 1 179 ? 26.903 -2.837 -41.925 1.00 25.96 ? 248 ILE A C 1 ATOM 1337 O O . ILE A 1 179 ? 28.045 -2.771 -41.460 1.00 26.99 ? 248 ILE A O 1 ATOM 1338 C CB . ILE A 1 179 ? 26.291 -0.477 -42.286 1.00 25.65 ? 248 ILE A CB 1 ATOM 1339 C CG1 . ILE A 1 179 ? 25.535 0.765 -41.762 1.00 26.78 ? 248 ILE A CG1 1 ATOM 1340 C CG2 . ILE A 1 179 ? 26.109 -0.624 -43.803 1.00 26.21 ? 248 ILE A CG2 1 ATOM 1341 C CD1 . ILE A 1 179 ? 24.052 0.754 -42.034 1.00 26.53 ? 248 ILE A CD1 1 ATOM 1342 N N . SER A 1 180 ? 26.514 -3.816 -42.743 1.00 25.50 ? 249 SER A N 1 ATOM 1343 C CA . SER A 1 180 ? 27.452 -4.754 -43.344 1.00 24.39 ? 249 SER A CA 1 ATOM 1344 C C . SER A 1 180 ? 27.077 -4.993 -44.820 1.00 23.82 ? 249 SER A C 1 ATOM 1345 O O . SER A 1 180 ? 26.407 -5.968 -45.163 1.00 23.42 ? 249 SER A O 1 ATOM 1346 C CB . SER A 1 180 ? 27.486 -6.055 -42.547 1.00 24.10 ? 249 SER A CB 1 ATOM 1347 O OG . SER A 1 180 ? 28.055 -5.854 -41.266 1.00 23.84 ? 249 SER A OG 1 ATOM 1348 N N . GLU A 1 181 ? 27.522 -4.085 -45.682 1.00 23.52 ? 250 GLU A N 1 ATOM 1349 C CA . GLU A 1 181 ? 27.186 -4.109 -47.112 1.00 23.34 ? 250 GLU A CA 1 ATOM 1350 C C . GLU A 1 181 ? 28.055 -5.127 -47.807 1.00 22.92 ? 250 GLU A C 1 ATOM 1351 O O . GLU A 1 181 ? 29.278 -4.960 -47.883 1.00 22.91 ? 250 GLU A O 1 ATOM 1352 C CB . GLU A 1 181 ? 27.341 -2.713 -47.728 1.00 23.82 ? 250 GLU A CB 1 ATOM 1353 C CG . GLU A 1 181 ? 26.244 -1.755 -47.228 1.00 26.32 ? 250 GLU A CG 1 ATOM 1354 C CD . GLU A 1 181 ? 26.429 -0.303 -47.608 1.00 30.98 ? 250 GLU A CD 1 ATOM 1355 O OE1 . GLU A 1 181 ? 27.134 -0.048 -48.616 1.00 32.82 ? 250 GLU A OE1 1 ATOM 1356 O OE2 . GLU A 1 181 ? 25.839 0.582 -46.908 1.00 31.57 ? 250 GLU A OE2 1 ATOM 1357 N N . CYS A 1 182 ? 27.432 -6.217 -48.245 1.00 21.86 ? 251 CYS A N 1 ATOM 1358 C CA . CYS A 1 182 ? 28.153 -7.295 -48.903 1.00 22.21 ? 251 CYS A CA 1 ATOM 1359 C C . CYS A 1 182 ? 28.488 -6.942 -50.371 1.00 22.04 ? 251 CYS A C 1 ATOM 1360 O O . CYS A 1 182 ? 27.895 -6.032 -50.951 1.00 22.22 ? 251 CYS A O 1 ATOM 1361 C CB . CYS A 1 182 ? 27.322 -8.590 -48.863 1.00 22.42 ? 251 CYS A CB 1 ATOM 1362 S SG . CYS A 1 182 ? 25.988 -8.686 -50.130 1.00 22.51 ? 251 CYS A SG 1 ATOM 1363 N N . ARG A 1 183 ? 29.465 -7.658 -50.930 1.00 21.48 ? 252 ARG A N 1 ATOM 1364 C CA . ARG A 1 183 ? 29.724 -7.691 -52.368 1.00 20.82 ? 252 ARG A CA 1 ATOM 1365 C C . ARG A 1 183 ? 29.844 -9.138 -52.779 1.00 20.40 ? 252 ARG A C 1 ATOM 1366 O O . ARG A 1 183 ? 29.862 -10.035 -51.933 1.00 19.66 ? 252 ARG A O 1 ATOM 1367 C CB . ARG A 1 183 ? 31.047 -7.012 -52.734 1.00 21.20 ? 252 ARG A CB 1 ATOM 1368 C CG . ARG A 1 183 ? 31.639 -6.116 -51.641 1.00 22.00 ? 252 ARG A CG 1 ATOM 1369 C CD . ARG A 1 183 ? 32.871 -5.383 -52.148 1.00 20.91 ? 252 ARG A CD 1 ATOM 1370 N NE . ARG A 1 183 ? 32.870 -4.011 -51.671 1.00 19.91 ? 252 ARG A NE 1 ATOM 1371 C CZ . ARG A 1 183 ? 33.918 -3.202 -51.662 1.00 19.33 ? 252 ARG A CZ 1 ATOM 1372 N NH1 . ARG A 1 183 ? 35.118 -3.587 -52.104 1.00 19.23 ? 252 ARG A NH1 1 ATOM 1373 N NH2 . ARG A 1 183 ? 33.760 -1.986 -51.187 1.00 20.48 ? 252 ARG A NH2 1 ATOM 1374 N N . PHE A 1 184 ? 29.941 -9.335 -54.091 1.00 19.91 ? 253 PHE A N 1 ATOM 1375 C CA . PHE A 1 184 ? 30.172 -10.632 -54.695 1.00 19.86 ? 253 PHE A CA 1 ATOM 1376 C C . PHE A 1 184 ? 31.423 -10.561 -55.538 1.00 19.22 ? 253 PHE A C 1 ATOM 1377 O O . PHE A 1 184 ? 31.713 -9.534 -56.152 1.00 18.74 ? 253 PHE A O 1 ATOM 1378 C CB . PHE A 1 184 ? 28.992 -11.045 -55.582 1.00 20.24 ? 253 PHE A CB 1 ATOM 1379 C CG . PHE A 1 184 ? 27.857 -11.639 -54.827 1.00 21.52 ? 253 PHE A CG 1 ATOM 1380 C CD1 . PHE A 1 184 ? 27.726 -13.018 -54.717 1.00 21.40 ? 253 PHE A CD1 1 ATOM 1381 C CD2 . PHE A 1 184 ? 26.943 -10.824 -54.181 1.00 21.75 ? 253 PHE A CD2 1 ATOM 1382 C CE1 . PHE A 1 184 ? 26.701 -13.557 -54.005 1.00 20.84 ? 253 PHE A CE1 1 ATOM 1383 C CE2 . PHE A 1 184 ? 25.918 -11.364 -53.470 1.00 22.08 ? 253 PHE A CE2 1 ATOM 1384 C CZ . PHE A 1 184 ? 25.793 -12.742 -53.384 1.00 22.52 ? 253 PHE A CZ 1 ATOM 1385 N N . LEU A 1 185 ? 32.164 -11.658 -55.532 1.00 18.71 ? 254 LEU A N 1 ATOM 1386 C CA . LEU A 1 185 ? 33.393 -11.789 -56.273 1.00 17.94 ? 254 LEU A CA 1 ATOM 1387 C C . LEU A 1 185 ? 33.142 -12.881 -57.301 1.00 17.73 ? 254 LEU A C 1 ATOM 1388 O O . LEU A 1 185 ? 32.351 -13.795 -57.071 1.00 17.16 ? 254 LEU A O 1 ATOM 1389 C CB . LEU A 1 185 ? 34.541 -12.173 -55.332 1.00 17.78 ? 254 LEU A CB 1 ATOM 1390 C CG . LEU A 1 185 ? 34.940 -11.192 -54.215 1.00 17.03 ? 254 LEU A CG 1 ATOM 1391 C CD1 . LEU A 1 185 ? 36.169 -11.706 -53.450 1.00 14.98 ? 254 LEU A CD1 1 ATOM 1392 C CD2 . LEU A 1 185 ? 35.199 -9.802 -54.707 1.00 14.23 ? 254 LEU A CD2 1 ATOM 1393 N N . LYS A 1 186 ? 33.787 -12.742 -58.449 1.00 17.61 ? 255 LYS A N 1 ATOM 1394 C CA . LYS A 1 186 ? 33.745 -13.738 -59.504 1.00 17.36 ? 255 LYS A CA 1 ATOM 1395 C C . LYS A 1 186 ? 35.191 -14.268 -59.671 1.00 17.38 ? 255 LYS A C 1 ATOM 1396 O O . LYS A 1 186 ? 36.119 -13.512 -59.996 1.00 17.93 ? 255 LYS A O 1 ATOM 1397 C CB . LYS A 1 186 ? 33.178 -13.104 -60.778 1.00 17.31 ? 255 LYS A CB 1 ATOM 1398 C CG . LYS A 1 186 ? 33.452 -13.838 -62.083 1.00 17.33 ? 255 LYS A CG 1 ATOM 1399 C CD . LYS A 1 186 ? 32.593 -13.247 -63.210 1.00 16.91 ? 255 LYS A CD 1 ATOM 1400 C CE . LYS A 1 186 ? 32.845 -13.889 -64.586 1.00 18.58 ? 255 LYS A CE 1 ATOM 1401 N NZ . LYS A 1 186 ? 32.051 -13.216 -65.681 1.00 15.80 ? 255 LYS A NZ 1 ATOM 1402 N N . ILE A 1 187 ? 35.362 -15.566 -59.414 1.00 17.10 ? 256 ILE A N 1 ATOM 1403 C CA . ILE A 1 187 ? 36.674 -16.197 -59.235 1.00 16.98 ? 256 ILE A CA 1 ATOM 1404 C C . ILE A 1 187 ? 36.819 -17.262 -60.310 1.00 17.11 ? 256 ILE A C 1 ATOM 1405 O O . ILE A 1 187 ? 35.884 -18.034 -60.569 1.00 17.13 ? 256 ILE A O 1 ATOM 1406 C CB . ILE A 1 187 ? 36.789 -16.848 -57.809 1.00 16.49 ? 256 ILE A CB 1 ATOM 1407 C CG1 . ILE A 1 187 ? 36.443 -15.822 -56.708 1.00 16.27 ? 256 ILE A CG1 1 ATOM 1408 C CG2 . ILE A 1 187 ? 38.165 -17.413 -57.586 1.00 15.91 ? 256 ILE A CG2 1 ATOM 1409 C CD1 . ILE A 1 187 ? 36.244 -16.414 -55.277 1.00 14.44 ? 256 ILE A CD1 1 ATOM 1410 N N . ARG A 1 188 ? 37.966 -17.296 -60.960 1.00 17.56 ? 257 ARG A N 1 ATOM 1411 C CA . ARG A 1 188 ? 38.162 -18.195 -62.100 1.00 18.23 ? 257 ARG A CA 1 ATOM 1412 C C . ARG A 1 188 ? 39.574 -18.750 -62.051 1.00 18.44 ? 257 ARG A C 1 ATOM 1413 O O . ARG A 1 188 ? 40.556 -18.011 -61.991 1.00 18.63 ? 257 ARG A O 1 ATOM 1414 C CB . ARG A 1 188 ? 37.881 -17.479 -63.433 1.00 17.89 ? 257 ARG A CB 1 ATOM 1415 C CG . ARG A 1 188 ? 38.049 -18.391 -64.658 1.00 19.49 ? 257 ARG A CG 1 ATOM 1416 C CD . ARG A 1 188 ? 37.803 -17.656 -66.000 1.00 21.53 ? 257 ARG A CD 1 ATOM 1417 N NE . ARG A 1 188 ? 37.901 -18.616 -67.093 1.00 21.27 ? 257 ARG A NE 1 ATOM 1418 C CZ . ARG A 1 188 ? 36.936 -19.447 -67.475 1.00 22.43 ? 257 ARG A CZ 1 ATOM 1419 N NH1 . ARG A 1 188 ? 35.742 -19.459 -66.879 1.00 22.55 ? 257 ARG A NH1 1 ATOM 1420 N NH2 . ARG A 1 188 ? 37.171 -20.299 -68.459 1.00 22.99 ? 257 ARG A NH2 1 ATOM 1421 N N . GLU A 1 189 ? 39.659 -20.074 -62.033 1.00 19.30 ? 258 GLU A N 1 ATOM 1422 C CA . GLU A 1 189 ? 40.907 -20.780 -61.717 1.00 19.75 ? 258 GLU A CA 1 ATOM 1423 C C . GLU A 1 189 ? 41.650 -20.153 -60.519 1.00 19.36 ? 258 GLU A C 1 ATOM 1424 O O . GLU A 1 189 ? 42.893 -20.114 -60.468 1.00 19.06 ? 258 GLU A O 1 ATOM 1425 C CB . GLU A 1 189 ? 41.752 -20.936 -62.995 1.00 19.86 ? 258 GLU A CB 1 ATOM 1426 C CG . GLU A 1 189 ? 41.069 -21.924 -63.957 1.00 21.70 ? 258 GLU A CG 1 ATOM 1427 C CD . GLU A 1 189 ? 41.720 -22.003 -65.329 1.00 23.43 ? 258 GLU A CD 1 ATOM 1428 O OE1 . GLU A 1 189 ? 41.759 -20.974 -66.018 1.00 25.48 ? 258 GLU A OE1 1 ATOM 1429 O OE2 . GLU A 1 189 ? 42.178 -23.100 -65.715 1.00 23.05 ? 258 GLU A OE2 1 ATOM 1430 N N . GLY A 1 190 ? 40.855 -19.677 -59.554 1.00 19.56 ? 259 GLY A N 1 ATOM 1431 C CA . GLY A 1 190 ? 41.363 -19.221 -58.232 1.00 19.56 ? 259 GLY A CA 1 ATOM 1432 C C . GLY A 1 190 ? 41.732 -17.751 -58.141 1.00 19.46 ? 259 GLY A C 1 ATOM 1433 O O . GLY A 1 190 ? 42.077 -17.278 -57.056 1.00 19.25 ? 259 GLY A O 1 ATOM 1434 N N . ARG A 1 191 ? 41.670 -17.020 -59.264 1.00 19.08 ? 260 ARG A N 1 ATOM 1435 C CA . ARG A 1 191 ? 41.907 -15.565 -59.242 1.00 19.00 ? 260 ARG A CA 1 ATOM 1436 C C . ARG A 1 191 ? 40.624 -14.749 -59.435 1.00 18.63 ? 260 ARG A C 1 ATOM 1437 O O . ARG A 1 191 ? 39.772 -15.097 -60.231 1.00 17.93 ? 260 ARG A O 1 ATOM 1438 C CB . ARG A 1 191 ? 42.978 -15.167 -60.257 1.00 18.99 ? 260 ARG A CB 1 ATOM 1439 C CG . ARG A 1 191 ? 44.201 -16.064 -60.143 1.00 19.78 ? 260 ARG A CG 1 ATOM 1440 C CD . ARG A 1 191 ? 45.442 -15.531 -60.814 1.00 20.83 ? 260 ARG A CD 1 ATOM 1441 N NE . ARG A 1 191 ? 46.634 -16.177 -60.270 1.00 22.85 ? 260 ARG A NE 1 ATOM 1442 C CZ . ARG A 1 191 ? 46.896 -17.484 -60.324 1.00 24.32 ? 260 ARG A CZ 1 ATOM 1443 N NH1 . ARG A 1 191 ? 46.066 -18.342 -60.897 1.00 26.65 ? 260 ARG A NH1 1 ATOM 1444 N NH2 . ARG A 1 191 ? 47.995 -17.951 -59.760 1.00 26.69 ? 260 ARG A NH2 1 ATOM 1445 N N . ILE A 1 192 ? 40.500 -13.667 -58.671 1.00 18.74 ? 261 ILE A N 1 ATOM 1446 C CA . ILE A 1 192 ? 39.352 -12.770 -58.732 1.00 18.49 ? 261 ILE A CA 1 ATOM 1447 C C . ILE A 1 192 ? 39.402 -11.976 -60.056 1.00 19.14 ? 261 ILE A C 1 ATOM 1448 O O . ILE A 1 192 ? 40.260 -11.131 -60.224 1.00 18.57 ? 261 ILE A O 1 ATOM 1449 C CB . ILE A 1 192 ? 39.384 -11.799 -57.540 1.00 17.95 ? 261 ILE A CB 1 ATOM 1450 C CG1 . ILE A 1 192 ? 39.242 -12.584 -56.218 1.00 18.52 ? 261 ILE A CG1 1 ATOM 1451 C CG2 . ILE A 1 192 ? 38.302 -10.741 -57.684 1.00 17.64 ? 261 ILE A CG2 1 ATOM 1452 C CD1 . ILE A 1 192 ? 39.776 -11.871 -55.017 1.00 15.82 ? 261 ILE A CD1 1 ATOM 1453 N N . ILE A 1 193 ? 38.501 -12.271 -60.992 1.00 20.18 ? 262 ILE A N 1 ATOM 1454 C CA . ILE A 1 193 ? 38.449 -11.547 -62.283 1.00 20.72 ? 262 ILE A CA 1 ATOM 1455 C C . ILE A 1 193 ? 37.348 -10.475 -62.317 1.00 21.19 ? 262 ILE A C 1 ATOM 1456 O O . ILE A 1 193 ? 37.336 -9.654 -63.223 1.00 21.28 ? 262 ILE A O 1 ATOM 1457 C CB . ILE A 1 193 ? 38.301 -12.499 -63.518 1.00 20.82 ? 262 ILE A CB 1 ATOM 1458 C CG1 . ILE A 1 193 ? 36.972 -13.260 -63.494 1.00 20.81 ? 262 ILE A CG1 1 ATOM 1459 C CG2 . ILE A 1 193 ? 39.477 -13.490 -63.578 1.00 20.39 ? 262 ILE A CG2 1 ATOM 1460 C CD1 . ILE A 1 193 ? 36.706 -14.054 -64.737 1.00 18.62 ? 262 ILE A CD1 1 ATOM 1461 N N . LYS A 1 194 ? 36.427 -10.474 -61.346 1.00 21.57 ? 263 LYS A N 1 ATOM 1462 C CA . LYS A 1 194 ? 35.447 -9.396 -61.252 1.00 21.96 ? 263 LYS A CA 1 ATOM 1463 C C . LYS A 1 194 ? 34.877 -9.183 -59.831 1.00 22.47 ? 263 LYS A C 1 ATOM 1464 O O . LYS A 1 194 ? 34.787 -10.111 -59.005 1.00 22.78 ? 263 LYS A O 1 ATOM 1465 C CB . LYS A 1 194 ? 34.329 -9.594 -62.294 1.00 22.31 ? 263 LYS A CB 1 ATOM 1466 C CG . LYS A 1 194 ? 33.608 -8.315 -62.696 1.00 23.03 ? 263 LYS A CG 1 ATOM 1467 C CD . LYS A 1 194 ? 32.458 -8.567 -63.647 1.00 25.54 ? 263 LYS A CD 1 ATOM 1468 C CE . LYS A 1 194 ? 32.885 -8.406 -65.137 1.00 27.46 ? 263 LYS A CE 1 ATOM 1469 N NZ . LYS A 1 194 ? 31.802 -8.817 -66.102 1.00 27.48 ? 263 LYS A NZ 1 ATOM 1470 N N . GLU A 1 195 ? 34.535 -7.929 -59.562 1.00 22.95 ? 264 GLU A N 1 ATOM 1471 C CA . GLU A 1 195 ? 33.856 -7.513 -58.343 1.00 23.35 ? 264 GLU A CA 1 ATOM 1472 C C . GLU A 1 195 ? 32.450 -7.065 -58.711 1.00 23.16 ? 264 GLU A C 1 ATOM 1473 O O . GLU A 1 195 ? 32.278 -6.280 -59.651 1.00 23.32 ? 264 GLU A O 1 ATOM 1474 C CB . GLU A 1 195 ? 34.574 -6.326 -57.728 1.00 23.64 ? 264 GLU A CB 1 ATOM 1475 C CG . GLU A 1 195 ? 35.955 -6.629 -57.207 1.00 26.45 ? 264 GLU A CG 1 ATOM 1476 C CD . GLU A 1 195 ? 36.789 -5.390 -57.061 1.00 28.37 ? 264 GLU A CD 1 ATOM 1477 O OE1 . GLU A 1 195 ? 36.873 -4.859 -55.942 1.00 27.47 ? 264 GLU A OE1 1 ATOM 1478 O OE2 . GLU A 1 195 ? 37.340 -4.939 -58.086 1.00 33.74 ? 264 GLU A OE2 1 ATOM 1479 N N . ILE A 1 196 ? 31.457 -7.538 -57.960 1.00 22.75 ? 265 ILE A N 1 ATOM 1480 C CA . ILE A 1 196 ? 30.057 -7.171 -58.172 1.00 22.37 ? 265 ILE A CA 1 ATOM 1481 C C . ILE A 1 196 ? 29.525 -6.422 -56.923 1.00 22.44 ? 265 ILE A C 1 ATOM 1482 O O . ILE A 1 196 ? 29.645 -6.902 -55.761 1.00 21.33 ? 265 ILE A O 1 ATOM 1483 C CB . ILE A 1 196 ? 29.191 -8.412 -58.496 1.00 22.36 ? 265 ILE A CB 1 ATOM 1484 C CG1 . ILE A 1 196 ? 29.669 -9.078 -59.800 1.00 22.53 ? 265 ILE A CG1 1 ATOM 1485 C CG2 . ILE A 1 196 ? 27.750 -8.029 -58.681 1.00 21.62 ? 265 ILE A CG2 1 ATOM 1486 C CD1 . ILE A 1 196 ? 29.639 -10.574 -59.760 1.00 21.95 ? 265 ILE A CD1 1 ATOM 1487 N N . PHE A 1 197 ? 28.956 -5.242 -57.189 1.00 21.31 ? 266 PHE A N 1 ATOM 1488 C CA . PHE A 1 197 ? 28.388 -4.394 -56.177 1.00 20.82 ? 266 PHE A CA 1 ATOM 1489 C C . PHE A 1 197 ? 26.850 -4.424 -56.311 1.00 20.88 ? 266 PHE A C 1 ATOM 1490 O O . PHE A 1 197 ? 26.266 -3.881 -57.285 1.00 20.27 ? 266 PHE A O 1 ATOM 1491 C CB . PHE A 1 197 ? 28.956 -2.995 -56.346 1.00 21.09 ? 266 PHE A CB 1 ATOM 1492 C CG . PHE A 1 197 ? 30.459 -2.962 -56.359 1.00 20.65 ? 266 PHE A CG 1 ATOM 1493 C CD1 . PHE A 1 197 ? 31.177 -3.006 -55.165 1.00 18.81 ? 266 PHE A CD1 1 ATOM 1494 C CD2 . PHE A 1 197 ? 31.160 -2.909 -57.560 1.00 19.54 ? 266 PHE A CD2 1 ATOM 1495 C CE1 . PHE A 1 197 ? 32.571 -2.991 -55.164 1.00 20.16 ? 266 PHE A CE1 1 ATOM 1496 C CE2 . PHE A 1 197 ? 32.576 -2.907 -57.571 1.00 19.83 ? 266 PHE A CE2 1 ATOM 1497 C CZ . PHE A 1 197 ? 33.277 -2.934 -56.366 1.00 19.48 ? 266 PHE A CZ 1 ATOM 1498 N N . PRO A 1 198 ? 26.181 -5.117 -55.368 1.00 20.46 ? 267 PRO A N 1 ATOM 1499 C CA . PRO A 1 198 ? 24.729 -5.208 -55.466 1.00 20.12 ? 267 PRO A CA 1 ATOM 1500 C C . PRO A 1 198 ? 24.073 -3.866 -55.307 1.00 19.88 ? 267 PRO A C 1 ATOM 1501 O O . PRO A 1 198 ? 24.706 -2.939 -54.841 1.00 20.08 ? 267 PRO A O 1 ATOM 1502 C CB . PRO A 1 198 ? 24.372 -6.145 -54.325 1.00 20.49 ? 267 PRO A CB 1 ATOM 1503 C CG . PRO A 1 198 ? 25.583 -7.058 -54.253 1.00 20.14 ? 267 PRO A CG 1 ATOM 1504 C CD . PRO A 1 198 ? 26.724 -6.126 -54.442 1.00 20.03 ? 267 PRO A CD 1 ATOM 1505 N N . THR A 1 199 ? 22.837 -3.756 -55.764 1.00 19.57 ? 268 THR A N 1 ATOM 1506 C CA . THR A 1 199 ? 22.045 -2.552 -55.608 1.00 19.69 ? 268 THR A CA 1 ATOM 1507 C C . THR A 1 199 ? 20.810 -2.951 -54.842 1.00 19.01 ? 268 THR A C 1 ATOM 1508 O O . THR A 1 199 ? 20.562 -4.134 -54.651 1.00 20.04 ? 268 THR A O 1 ATOM 1509 C CB . THR A 1 199 ? 21.555 -2.006 -56.988 1.00 19.42 ? 268 THR A CB 1 ATOM 1510 O OG1 . THR A 1 199 ? 20.732 -2.991 -57.591 1.00 20.10 ? 268 THR A OG1 1 ATOM 1511 C CG2 . THR A 1 199 ? 22.689 -1.701 -57.905 1.00 19.88 ? 268 THR A CG2 1 ATOM 1512 N N . GLY A 1 200 ? 19.993 -1.986 -54.463 1.00 18.61 ? 269 GLY A N 1 ATOM 1513 C CA . GLY A 1 200 ? 18.746 -2.295 -53.764 1.00 18.79 ? 269 GLY A CA 1 ATOM 1514 C C . GLY A 1 200 ? 18.899 -2.296 -52.243 1.00 18.74 ? 269 GLY A C 1 ATOM 1515 O O . GLY A 1 200 ? 19.523 -1.400 -51.683 1.00 18.68 ? 269 GLY A O 1 ATOM 1516 N N . ARG A 1 201 ? 18.318 -3.289 -51.575 1.00 18.46 ? 270 ARG A N 1 ATOM 1517 C CA . ARG A 1 201 ? 18.277 -3.300 -50.103 1.00 18.49 ? 270 ARG A CA 1 ATOM 1518 C C . ARG A 1 201 ? 19.608 -3.840 -49.577 1.00 18.70 ? 270 ARG A C 1 ATOM 1519 O O . ARG A 1 201 ? 19.751 -5.053 -49.400 1.00 19.76 ? 270 ARG A O 1 ATOM 1520 C CB . ARG A 1 201 ? 17.089 -4.153 -49.624 1.00 18.36 ? 270 ARG A CB 1 ATOM 1521 C CG . ARG A 1 201 ? 16.598 -3.881 -48.177 1.00 17.89 ? 270 ARG A CG 1 ATOM 1522 C CD . ARG A 1 201 ? 17.533 -4.470 -47.149 1.00 16.90 ? 270 ARG A CD 1 ATOM 1523 N NE . ARG A 1 201 ? 17.064 -4.323 -45.766 1.00 16.64 ? 270 ARG A NE 1 ATOM 1524 C CZ . ARG A 1 201 ? 17.665 -4.892 -44.720 1.00 15.79 ? 270 ARG A CZ 1 ATOM 1525 N NH1 . ARG A 1 201 ? 18.762 -5.626 -44.917 1.00 14.91 ? 270 ARG A NH1 1 ATOM 1526 N NH2 . ARG A 1 201 ? 17.183 -4.733 -43.475 1.00 16.57 ? 270 ARG A NH2 1 ATOM 1527 N N . VAL A 1 202 ? 20.571 -2.954 -49.313 1.00 18.35 ? 271 VAL A N 1 ATOM 1528 C CA . VAL A 1 202 ? 21.953 -3.374 -49.031 1.00 18.24 ? 271 VAL A CA 1 ATOM 1529 C C . VAL A 1 202 ? 22.479 -3.157 -47.573 1.00 18.38 ? 271 VAL A C 1 ATOM 1530 O O . VAL A 1 202 ? 23.604 -3.562 -47.254 1.00 18.18 ? 271 VAL A O 1 ATOM 1531 C CB . VAL A 1 202 ? 22.911 -2.722 -50.045 1.00 18.19 ? 271 VAL A CB 1 ATOM 1532 C CG1 . VAL A 1 202 ? 24.315 -3.160 -49.778 1.00 19.04 ? 271 VAL A CG1 1 ATOM 1533 C CG2 . VAL A 1 202 ? 22.517 -3.092 -51.491 1.00 18.39 ? 271 VAL A CG2 1 ATOM 1534 N N . LYS A 1 203 ? 21.663 -2.575 -46.698 1.00 19.04 ? 272 LYS A N 1 ATOM 1535 C CA . LYS A 1 203 ? 22.050 -2.222 -45.292 1.00 20.19 ? 272 LYS A CA 1 ATOM 1536 C C . LYS A 1 203 ? 22.907 -3.287 -44.555 1.00 19.71 ? 272 LYS A C 1 ATOM 1537 O O . LYS A 1 203 ? 23.993 -2.992 -44.039 1.00 18.95 ? 272 LYS A O 1 ATOM 1538 C CB . LYS A 1 203 ? 20.783 -1.994 -44.468 1.00 21.12 ? 272 LYS A CB 1 ATOM 1539 C CG . LYS A 1 203 ? 20.806 -0.823 -43.538 1.00 23.39 ? 272 LYS A CG 1 ATOM 1540 C CD . LYS A 1 203 ? 19.446 -0.691 -42.871 1.00 25.11 ? 272 LYS A CD 1 ATOM 1541 C CE . LYS A 1 203 ? 19.471 0.252 -41.637 1.00 26.13 ? 272 LYS A CE 1 ATOM 1542 N NZ . LYS A 1 203 ? 18.140 0.243 -40.973 1.00 25.79 ? 272 LYS A NZ 1 ATOM 1543 N N . HIS A 1 204 ? 22.409 -4.520 -44.540 1.00 19.58 ? 273 HIS A N 1 ATOM 1544 C CA . HIS A 1 204 ? 23.051 -5.619 -43.814 1.00 19.90 ? 273 HIS A CA 1 ATOM 1545 C C . HIS A 1 204 ? 22.800 -6.976 -44.462 1.00 19.73 ? 273 HIS A C 1 ATOM 1546 O O . HIS A 1 204 ? 21.696 -7.482 -44.446 1.00 20.06 ? 273 HIS A O 1 ATOM 1547 C CB . HIS A 1 204 ? 22.558 -5.668 -42.361 1.00 19.97 ? 273 HIS A CB 1 ATOM 1548 C CG . HIS A 1 204 ? 23.420 -6.508 -41.469 1.00 19.82 ? 273 HIS A CG 1 ATOM 1549 N ND1 . HIS A 1 204 ? 24.079 -5.995 -40.376 1.00 19.70 ? 273 HIS A ND1 1 ATOM 1550 C CD2 . HIS A 1 204 ? 23.753 -7.818 -41.531 1.00 21.32 ? 273 HIS A CD2 1 ATOM 1551 C CE1 . HIS A 1 204 ? 24.780 -6.955 -39.798 1.00 22.27 ? 273 HIS A CE1 1 ATOM 1552 N NE2 . HIS A 1 204 ? 24.592 -8.074 -40.476 1.00 21.54 ? 273 HIS A NE2 1 ATOM 1553 N N . THR A 1 205 ? 23.844 -7.567 -45.012 1.00 20.05 ? 274 THR A N 1 ATOM 1554 C CA . THR A 1 205 ? 23.760 -8.875 -45.625 1.00 20.01 ? 274 THR A CA 1 ATOM 1555 C C . THR A 1 205 ? 25.021 -9.646 -45.258 1.00 20.06 ? 274 THR A C 1 ATOM 1556 O O . THR A 1 205 ? 26.142 -9.159 -45.481 1.00 21.06 ? 274 THR A O 1 ATOM 1557 C CB . THR A 1 205 ? 23.663 -8.770 -47.174 1.00 20.52 ? 274 THR A CB 1 ATOM 1558 O OG1 . THR A 1 205 ? 22.649 -7.820 -47.552 1.00 20.12 ? 274 THR A OG1 1 ATOM 1559 C CG2 . THR A 1 205 ? 23.350 -10.130 -47.790 1.00 20.08 ? 274 THR A CG2 1 ATOM 1560 N N . GLU A 1 206 ? 24.849 -10.839 -44.699 1.00 19.03 ? 275 GLU A N 1 ATOM 1561 C CA . GLU A 1 206 ? 25.973 -11.700 -44.371 1.00 18.87 ? 275 GLU A CA 1 ATOM 1562 C C . GLU A 1 206 ? 25.509 -13.145 -44.392 1.00 18.19 ? 275 GLU A C 1 ATOM 1563 O O . GLU A 1 206 ? 24.305 -13.409 -44.391 1.00 18.18 ? 275 GLU A O 1 ATOM 1564 C CB . GLU A 1 206 ? 26.550 -11.343 -42.987 1.00 18.34 ? 275 GLU A CB 1 ATOM 1565 C CG . GLU A 1 206 ? 25.791 -11.900 -41.793 1.00 20.44 ? 275 GLU A CG 1 ATOM 1566 C CD . GLU A 1 206 ? 26.433 -11.511 -40.441 1.00 22.70 ? 275 GLU A CD 1 ATOM 1567 O OE1 . GLU A 1 206 ? 26.369 -10.322 -40.058 1.00 24.35 ? 275 GLU A OE1 1 ATOM 1568 O OE2 . GLU A 1 206 ? 27.020 -12.388 -39.779 1.00 21.28 ? 275 GLU A OE2 1 ATOM 1569 N N . GLU A 1 207 ? 26.469 -14.070 -44.363 1.00 17.26 ? 276 GLU A N 1 ATOM 1570 C CA . GLU A 1 207 ? 26.197 -15.521 -44.357 1.00 16.52 ? 276 GLU A CA 1 ATOM 1571 C C . GLU A 1 207 ? 25.200 -16.002 -45.425 1.00 16.74 ? 276 GLU A C 1 ATOM 1572 O O . GLU A 1 207 ? 24.368 -16.876 -45.165 1.00 16.70 ? 276 GLU A O 1 ATOM 1573 C CB . GLU A 1 207 ? 25.786 -15.962 -42.950 1.00 16.28 ? 276 GLU A CB 1 ATOM 1574 C CG . GLU A 1 207 ? 26.982 -15.930 -41.972 1.00 16.19 ? 276 GLU A CG 1 ATOM 1575 C CD . GLU A 1 207 ? 26.591 -16.274 -40.543 1.00 17.23 ? 276 GLU A CD 1 ATOM 1576 O OE1 . GLU A 1 207 ? 27.471 -16.477 -39.656 1.00 18.09 ? 276 GLU A OE1 1 ATOM 1577 O OE2 . GLU A 1 207 ? 25.387 -16.357 -40.311 1.00 16.10 ? 276 GLU A OE2 1 ATOM 1578 N N . CYS A 1 208 ? 25.295 -15.442 -46.634 1.00 16.57 ? 277 CYS A N 1 ATOM 1579 C CA . CYS A 1 208 ? 24.416 -15.848 -47.722 1.00 16.78 ? 277 CYS A CA 1 ATOM 1580 C C . CYS A 1 208 ? 24.549 -17.298 -48.069 1.00 16.22 ? 277 CYS A C 1 ATOM 1581 O O . CYS A 1 208 ? 25.637 -17.780 -48.292 1.00 16.52 ? 277 CYS A O 1 ATOM 1582 C CB . CYS A 1 208 ? 24.684 -15.036 -49.004 1.00 17.22 ? 277 CYS A CB 1 ATOM 1583 S SG . CYS A 1 208 ? 24.218 -13.319 -48.861 1.00 18.94 ? 277 CYS A SG 1 ATOM 1584 N N . THR A 1 209 ? 23.421 -17.986 -48.123 1.00 16.72 ? 278 THR A N 1 ATOM 1585 C CA . THR A 1 209 ? 23.360 -19.332 -48.639 1.00 17.51 ? 278 THR A CA 1 ATOM 1586 C C . THR A 1 209 ? 22.830 -19.215 -50.072 1.00 18.11 ? 278 THR A C 1 ATOM 1587 O O . THR A 1 209 ? 21.719 -18.727 -50.284 1.00 18.71 ? 278 THR A O 1 ATOM 1588 C CB . THR A 1 209 ? 22.475 -20.157 -47.751 1.00 17.49 ? 278 THR A CB 1 ATOM 1589 O OG1 . THR A 1 209 ? 22.989 -20.074 -46.407 1.00 18.16 ? 278 THR A OG1 1 ATOM 1590 C CG2 . THR A 1 209 ? 22.420 -21.611 -48.206 1.00 17.73 ? 278 THR A CG2 1 ATOM 1591 N N . CYS A 1 210 ? 23.635 -19.622 -51.049 1.00 18.69 ? 279 CYS A N 1 ATOM 1592 C CA . CYS A 1 210 ? 23.345 -19.373 -52.462 1.00 19.44 ? 279 CYS A CA 1 ATOM 1593 C C . CYS A 1 210 ? 23.245 -20.655 -53.276 1.00 19.52 ? 279 CYS A C 1 ATOM 1594 O O . CYS A 1 210 ? 23.799 -21.675 -52.894 1.00 19.58 ? 279 CYS A O 1 ATOM 1595 C CB . CYS A 1 210 ? 24.465 -18.532 -53.086 1.00 19.79 ? 279 CYS A CB 1 ATOM 1596 S SG . CYS A 1 210 ? 24.869 -16.976 -52.316 1.00 21.80 ? 279 CYS A SG 1 ATOM 1597 N N . GLY A 1 211 ? 22.576 -20.582 -54.420 1.00 19.54 ? 280 GLY A N 1 ATOM 1598 C CA . GLY A 1 211 ? 22.585 -21.663 -55.412 1.00 19.94 ? 280 GLY A CA 1 ATOM 1599 C C . GLY A 1 211 ? 22.074 -21.139 -56.753 1.00 20.51 ? 280 GLY A C 1 ATOM 1600 O O . GLY A 1 211 ? 21.630 -19.993 -56.837 1.00 20.10 ? 280 GLY A O 1 ATOM 1601 N N . PHE A 1 212 ? 22.092 -21.969 -57.789 1.00 20.97 ? 281 PHE A N 1 ATOM 1602 C CA . PHE A 1 212 ? 21.581 -21.542 -59.111 1.00 22.10 ? 281 PHE A CA 1 ATOM 1603 C C . PHE A 1 212 ? 20.077 -21.756 -59.264 1.00 22.50 ? 281 PHE A C 1 ATOM 1604 O O . PHE A 1 212 ? 19.608 -22.877 -59.148 1.00 23.50 ? 281 PHE A O 1 ATOM 1605 C CB . PHE A 1 212 ? 22.263 -22.304 -60.232 1.00 21.57 ? 281 PHE A CB 1 ATOM 1606 C CG . PHE A 1 212 ? 23.663 -21.895 -60.486 1.00 22.36 ? 281 PHE A CG 1 ATOM 1607 C CD1 . PHE A 1 212 ? 23.949 -20.789 -61.263 1.00 22.39 ? 281 PHE A CD1 1 ATOM 1608 C CD2 . PHE A 1 212 ? 24.724 -22.650 -60.000 1.00 23.19 ? 281 PHE A CD2 1 ATOM 1609 C CE1 . PHE A 1 212 ? 25.277 -20.429 -61.523 1.00 20.64 ? 281 PHE A CE1 1 ATOM 1610 C CE2 . PHE A 1 212 ? 26.036 -22.286 -60.268 1.00 20.84 ? 281 PHE A CE2 1 ATOM 1611 C CZ . PHE A 1 212 ? 26.304 -21.184 -61.031 1.00 19.29 ? 281 PHE A CZ 1 ATOM 1612 N N . ALA A 1 213 ? 19.332 -20.694 -59.539 1.00 23.14 ? 282 ALA A N 1 ATOM 1613 C CA . ALA A 1 213 ? 17.956 -20.827 -60.046 1.00 23.52 ? 282 ALA A CA 1 ATOM 1614 C C . ALA A 1 213 ? 17.978 -21.286 -61.502 1.00 23.31 ? 282 ALA A C 1 ATOM 1615 O O . ALA A 1 213 ? 17.061 -21.963 -61.966 1.00 24.02 ? 282 ALA A O 1 ATOM 1616 C CB . ALA A 1 213 ? 17.199 -19.505 -59.935 1.00 22.94 ? 282 ALA A CB 1 ATOM 1617 N N . SER A 1 214 ? 19.020 -20.925 -62.231 1.00 23.21 ? 283 SER A N 1 ATOM 1618 C CA . SER A 1 214 ? 19.095 -21.251 -63.669 1.00 22.83 ? 283 SER A CA 1 ATOM 1619 C C . SER A 1 214 ? 20.515 -21.029 -64.160 1.00 22.89 ? 283 SER A C 1 ATOM 1620 O O . SER A 1 214 ? 21.407 -20.745 -63.360 1.00 22.05 ? 283 SER A O 1 ATOM 1621 C CB . SER A 1 214 ? 18.158 -20.336 -64.457 1.00 22.42 ? 283 SER A CB 1 ATOM 1622 O OG . SER A 1 214 ? 18.690 -19.003 -64.471 1.00 21.97 ? 283 SER A OG 1 ATOM 1623 N N . ASN A 1 215 ? 20.706 -21.143 -65.479 1.00 23.81 ? 284 ASN A N 1 ATOM 1624 C CA . ASN A 1 215 ? 21.981 -20.808 -66.129 1.00 24.30 ? 284 ASN A CA 1 ATOM 1625 C C . ASN A 1 215 ? 22.250 -19.293 -66.204 1.00 24.41 ? 284 ASN A C 1 ATOM 1626 O O . ASN A 1 215 ? 23.380 -18.862 -66.450 1.00 25.01 ? 284 ASN A O 1 ATOM 1627 C CB . ASN A 1 215 ? 22.037 -21.390 -67.544 1.00 24.62 ? 284 ASN A CB 1 ATOM 1628 C CG . ASN A 1 215 ? 22.369 -22.881 -67.581 1.00 26.95 ? 284 ASN A CG 1 ATOM 1629 O OD1 . ASN A 1 215 ? 23.388 -23.345 -67.037 1.00 25.53 ? 284 ASN A OD1 1 ATOM 1630 N ND2 . ASN A 1 215 ? 21.516 -23.641 -68.263 1.00 32.65 ? 284 ASN A ND2 1 ATOM 1631 N N . LYS A 1 216 ? 21.209 -18.490 -66.030 1.00 24.88 ? 285 LYS A N 1 ATOM 1632 C CA . LYS A 1 216 ? 21.349 -17.048 -65.922 1.00 25.29 ? 285 LYS A CA 1 ATOM 1633 C C . LYS A 1 216 ? 21.474 -16.511 -64.503 1.00 24.48 ? 285 LYS A C 1 ATOM 1634 O O . LYS A 1 216 ? 22.118 -15.502 -64.299 1.00 25.34 ? 285 LYS A O 1 ATOM 1635 C CB . LYS A 1 216 ? 20.111 -16.367 -66.454 1.00 26.41 ? 285 LYS A CB 1 ATOM 1636 C CG . LYS A 1 216 ? 19.962 -16.311 -67.939 1.00 28.45 ? 285 LYS A CG 1 ATOM 1637 C CD . LYS A 1 216 ? 18.841 -15.331 -68.287 1.00 31.98 ? 285 LYS A CD 1 ATOM 1638 C CE . LYS A 1 216 ? 18.896 -13.993 -67.485 1.00 33.00 ? 285 LYS A CE 1 ATOM 1639 N NZ . LYS A 1 216 ? 17.548 -13.349 -67.379 1.00 34.87 ? 285 LYS A NZ 1 ATOM 1640 N N . THR A 1 217 ? 20.821 -17.136 -63.538 1.00 23.20 ? 286 THR A N 1 ATOM 1641 C CA . THR A 1 217 ? 20.618 -16.509 -62.235 1.00 22.55 ? 286 THR A CA 1 ATOM 1642 C C . THR A 1 217 ? 21.088 -17.340 -61.050 1.00 21.44 ? 286 THR A C 1 ATOM 1643 O O . THR A 1 217 ? 20.855 -18.537 -61.001 1.00 21.65 ? 286 THR A O 1 ATOM 1644 C CB . THR A 1 217 ? 19.135 -16.208 -62.034 1.00 22.98 ? 286 THR A CB 1 ATOM 1645 O OG1 . THR A 1 217 ? 18.706 -15.351 -63.100 1.00 26.04 ? 286 THR A OG1 1 ATOM 1646 C CG2 . THR A 1 217 ? 18.863 -15.516 -60.666 1.00 22.43 ? 286 THR A CG2 1 ATOM 1647 N N . ILE A 1 218 ? 21.753 -16.681 -60.110 1.00 19.98 ? 287 ILE A N 1 ATOM 1648 C CA . ILE A 1 218 ? 22.081 -17.244 -58.801 1.00 19.78 ? 287 ILE A CA 1 ATOM 1649 C C . ILE A 1 218 ? 21.208 -16.512 -57.804 1.00 19.00 ? 287 ILE A C 1 ATOM 1650 O O . ILE A 1 218 ? 21.046 -15.304 -57.903 1.00 19.45 ? 287 ILE A O 1 ATOM 1651 C CB . ILE A 1 218 ? 23.589 -17.013 -58.394 1.00 19.39 ? 287 ILE A CB 1 ATOM 1652 C CG1 . ILE A 1 218 ? 24.514 -17.951 -59.161 1.00 19.04 ? 287 ILE A CG1 1 ATOM 1653 C CG2 . ILE A 1 218 ? 23.822 -17.236 -56.886 1.00 19.77 ? 287 ILE A CG2 1 ATOM 1654 C CD1 . ILE A 1 218 ? 25.992 -17.542 -59.177 1.00 15.74 ? 287 ILE A CD1 1 ATOM 1655 N N . GLU A 1 219 ? 20.667 -17.233 -56.838 1.00 18.62 ? 288 GLU A N 1 ATOM 1656 C CA . GLU A 1 219 ? 19.953 -16.598 -55.724 1.00 18.37 ? 288 GLU A CA 1 ATOM 1657 C C . GLU A 1 219 ? 20.564 -16.983 -54.387 1.00 18.29 ? 288 GLU A C 1 ATOM 1658 O O . GLU A 1 219 ? 21.226 -18.011 -54.277 1.00 18.02 ? 288 GLU A O 1 ATOM 1659 C CB . GLU A 1 219 ? 18.478 -16.999 -55.728 1.00 18.36 ? 288 GLU A CB 1 ATOM 1660 C CG . GLU A 1 219 ? 17.775 -16.803 -57.066 1.00 18.33 ? 288 GLU A CG 1 ATOM 1661 C CD . GLU A 1 219 ? 16.333 -17.234 -57.030 1.00 16.82 ? 288 GLU A CD 1 ATOM 1662 O OE1 . GLU A 1 219 ? 16.055 -18.393 -56.644 1.00 18.01 ? 288 GLU A OE1 1 ATOM 1663 O OE2 . GLU A 1 219 ? 15.469 -16.408 -57.381 1.00 16.45 ? 288 GLU A OE2 1 ATOM 1664 N N . CYS A 1 220 ? 20.301 -16.171 -53.369 1.00 18.56 ? 289 CYS A N 1 ATOM 1665 C CA . CYS A 1 220 ? 20.792 -16.429 -52.016 1.00 18.92 ? 289 CYS A CA 1 ATOM 1666 C C . CYS A 1 220 ? 19.807 -15.939 -50.945 1.00 17.90 ? 289 CYS A C 1 ATOM 1667 O O . CYS A 1 220 ? 19.146 -14.917 -51.129 1.00 18.16 ? 289 CYS A O 1 ATOM 1668 C CB . CYS A 1 220 ? 22.138 -15.722 -51.767 1.00 19.41 ? 289 CYS A CB 1 ATOM 1669 S SG . CYS A 1 220 ? 23.435 -15.700 -53.061 1.00 22.89 ? 289 CYS A SG 1 ATOM 1670 N N . ALA A 1 221 ? 19.731 -16.667 -49.840 1.00 16.89 ? 290 ALA A N 1 ATOM 1671 C CA . ALA A 1 221 ? 18.941 -16.278 -48.666 1.00 16.95 ? 290 ALA A CA 1 ATOM 1672 C C . ALA A 1 221 ? 19.964 -16.002 -47.591 1.00 16.68 ? 290 ALA A C 1 ATOM 1673 O O . ALA A 1 221 ? 20.776 -16.887 -47.264 1.00 15.89 ? 290 ALA A O 1 ATOM 1674 C CB . ALA A 1 221 ? 18.003 -17.410 -48.231 1.00 16.57 ? 290 ALA A CB 1 ATOM 1675 N N . CYS A 1 222 ? 19.975 -14.769 -47.091 1.00 16.67 ? 291 CYS A N 1 ATOM 1676 C CA . CYS A 1 222 ? 21.102 -14.286 -46.269 1.00 16.53 ? 291 CYS A CA 1 ATOM 1677 C C . CYS A 1 222 ? 20.625 -13.989 -44.859 1.00 16.39 ? 291 CYS A C 1 ATOM 1678 O O . CYS A 1 222 ? 19.494 -14.351 -44.508 1.00 15.37 ? 291 CYS A O 1 ATOM 1679 C CB . CYS A 1 222 ? 21.779 -13.080 -46.922 1.00 16.31 ? 291 CYS A CB 1 ATOM 1680 S SG . CYS A 1 222 ? 22.128 -13.302 -48.716 1.00 17.05 ? 291 CYS A SG 1 ATOM 1681 N N . ARG A 1 223 ? 21.477 -13.362 -44.051 1.00 16.48 ? 292 ARG A N 1 ATOM 1682 C CA . ARG A 1 223 ? 21.121 -13.022 -42.652 1.00 17.20 ? 292 ARG A CA 1 ATOM 1683 C C . ARG A 1 223 ? 21.298 -11.532 -42.419 1.00 18.24 ? 292 ARG A C 1 ATOM 1684 O O . ARG A 1 223 ? 22.321 -10.976 -42.820 1.00 18.60 ? 292 ARG A O 1 ATOM 1685 C CB . ARG A 1 223 ? 21.996 -13.812 -41.706 1.00 17.29 ? 292 ARG A CB 1 ATOM 1686 C CG . ARG A 1 223 ? 22.092 -13.362 -40.276 1.00 16.14 ? 292 ARG A CG 1 ATOM 1687 C CD . ARG A 1 223 ? 23.243 -14.119 -39.644 1.00 15.60 ? 292 ARG A CD 1 ATOM 1688 N NE . ARG A 1 223 ? 23.433 -13.787 -38.233 1.00 15.95 ? 292 ARG A NE 1 ATOM 1689 C CZ . ARG A 1 223 ? 24.164 -14.492 -37.379 1.00 15.25 ? 292 ARG A CZ 1 ATOM 1690 N NH1 . ARG A 1 223 ? 24.782 -15.617 -37.755 1.00 14.47 ? 292 ARG A NH1 1 ATOM 1691 N NH2 . ARG A 1 223 ? 24.259 -14.079 -36.117 1.00 15.47 ? 292 ARG A NH2 1 ATOM 1692 N N . ASP A 1 224 ? 20.286 -10.879 -41.830 1.00 19.24 ? 293 ASP A N 1 ATOM 1693 C CA . ASP A 1 224 ? 20.435 -9.521 -41.309 1.00 20.09 ? 293 ASP A CA 1 ATOM 1694 C C . ASP A 1 224 ? 20.593 -9.668 -39.801 1.00 20.76 ? 293 ASP A C 1 ATOM 1695 O O . ASP A 1 224 ? 19.680 -10.135 -39.118 1.00 20.72 ? 293 ASP A O 1 ATOM 1696 C CB . ASP A 1 224 ? 19.218 -8.649 -41.649 1.00 20.55 ? 293 ASP A CB 1 ATOM 1697 C CG . ASP A 1 224 ? 19.443 -7.153 -41.341 1.00 21.32 ? 293 ASP A CG 1 ATOM 1698 O OD1 . ASP A 1 224 ? 20.033 -6.841 -40.267 1.00 23.29 ? 293 ASP A OD1 1 ATOM 1699 O OD2 . ASP A 1 224 ? 19.008 -6.291 -42.155 1.00 18.82 ? 293 ASP A OD2 1 ATOM 1700 N N . ASN A 1 225 ? 21.762 -9.300 -39.290 1.00 21.39 ? 294 ASN A N 1 ATOM 1701 C CA . ASN A 1 225 ? 22.050 -9.509 -37.878 1.00 21.90 ? 294 ASN A CA 1 ATOM 1702 C C . ASN A 1 225 ? 21.585 -8.388 -36.959 1.00 21.71 ? 294 ASN A C 1 ATOM 1703 O O . ASN A 1 225 ? 21.648 -8.523 -35.740 1.00 20.91 ? 294 ASN A O 1 ATOM 1704 C CB . ASN A 1 225 ? 23.537 -9.770 -37.638 1.00 21.50 ? 294 ASN A CB 1 ATOM 1705 C CG . ASN A 1 225 ? 23.768 -10.508 -36.323 1.00 21.59 ? 294 ASN A CG 1 ATOM 1706 O OD1 . ASN A 1 225 ? 23.260 -11.608 -36.143 1.00 20.24 ? 294 ASN A OD1 1 ATOM 1707 N ND2 . ASN A 1 225 ? 24.491 -9.895 -35.403 1.00 19.39 ? 294 ASN A ND2 1 ATOM 1708 N N . SER A 1 226 ? 21.102 -7.301 -37.560 1.00 22.25 ? 295 SER A N 1 ATOM 1709 C CA . SER A 1 226 ? 20.783 -6.082 -36.833 1.00 22.28 ? 295 SER A CA 1 ATOM 1710 C C . SER A 1 226 ? 19.336 -5.624 -36.933 1.00 21.99 ? 295 SER A C 1 ATOM 1711 O O . SER A 1 226 ? 18.743 -5.253 -35.923 1.00 21.78 ? 295 SER A O 1 ATOM 1712 C CB . SER A 1 226 ? 21.704 -4.972 -37.345 1.00 22.88 ? 295 SER A CB 1 ATOM 1713 O OG . SER A 1 226 ? 23.054 -5.437 -37.353 1.00 25.24 ? 295 SER A OG 1 ATOM 1714 N N . TYR A 1 227 ? 18.765 -5.666 -38.142 1.00 21.54 ? 296 TYR A N 1 ATOM 1715 C CA . TYR A 1 227 ? 17.595 -4.845 -38.462 1.00 21.21 ? 296 TYR A CA 1 ATOM 1716 C C . TYR A 1 227 ? 16.270 -5.575 -38.631 1.00 20.51 ? 296 TYR A C 1 ATOM 1717 O O . TYR A 1 227 ? 15.219 -4.959 -38.459 1.00 21.55 ? 296 TYR A O 1 ATOM 1718 C CB . TYR A 1 227 ? 17.882 -4.008 -39.734 1.00 21.57 ? 296 TYR A CB 1 ATOM 1719 C CG . TYR A 1 227 ? 19.079 -3.111 -39.557 1.00 22.64 ? 296 TYR A CG 1 ATOM 1720 C CD1 . TYR A 1 227 ? 19.116 -2.178 -38.508 1.00 23.98 ? 296 TYR A CD1 1 ATOM 1721 C CD2 . TYR A 1 227 ? 20.182 -3.201 -40.402 1.00 23.42 ? 296 TYR A CD2 1 ATOM 1722 C CE1 . TYR A 1 227 ? 20.213 -1.371 -38.303 1.00 24.74 ? 296 TYR A CE1 1 ATOM 1723 C CE2 . TYR A 1 227 ? 21.290 -2.385 -40.214 1.00 24.39 ? 296 TYR A CE2 1 ATOM 1724 C CZ . TYR A 1 227 ? 21.302 -1.482 -39.149 1.00 25.17 ? 296 TYR A CZ 1 ATOM 1725 O OH . TYR A 1 227 ? 22.388 -0.663 -38.944 1.00 26.62 ? 296 TYR A OH 1 ATOM 1726 N N . THR A 1 228 ? 16.299 -6.866 -38.949 1.00 19.30 ? 297 THR A N 1 ATOM 1727 C CA . THR A 1 228 ? 15.087 -7.541 -39.404 1.00 18.14 ? 297 THR A CA 1 ATOM 1728 C C . THR A 1 228 ? 15.226 -9.035 -39.320 1.00 17.28 ? 297 THR A C 1 ATOM 1729 O O . THR A 1 228 ? 16.322 -9.551 -39.343 1.00 16.54 ? 297 THR A O 1 ATOM 1730 C CB . THR A 1 228 ? 14.751 -7.182 -40.888 1.00 18.15 ? 297 THR A CB 1 ATOM 1731 O OG1 . THR A 1 228 ? 13.468 -7.721 -41.229 1.00 18.78 ? 297 THR A OG1 1 ATOM 1732 C CG2 . THR A 1 228 ? 15.803 -7.731 -41.860 1.00 15.78 ? 297 THR A CG2 1 ATOM 1733 N N . ALA A 1 229 ? 14.084 -9.709 -39.260 1.00 17.42 ? 298 ALA A N 1 ATOM 1734 C CA . ALA A 1 229 ? 14.010 -11.155 -39.188 1.00 16.95 ? 298 ALA A CA 1 ATOM 1735 C C . ALA A 1 229 ? 13.672 -11.743 -40.568 1.00 16.66 ? 298 ALA A C 1 ATOM 1736 O O . ALA A 1 229 ? 13.636 -12.959 -40.733 1.00 16.10 ? 298 ALA A O 1 ATOM 1737 C CB . ALA A 1 229 ? 12.985 -11.569 -38.149 1.00 16.65 ? 298 ALA A CB 1 ATOM 1738 N N . LYS A 1 230 ? 13.410 -10.878 -41.545 1.00 16.30 ? 299 LYS A N 1 ATOM 1739 C CA . LYS A 1 230 ? 13.231 -11.316 -42.932 1.00 16.28 ? 299 LYS A CA 1 ATOM 1740 C C . LYS A 1 230 ? 14.590 -11.554 -43.494 1.00 16.21 ? 299 LYS A C 1 ATOM 1741 O O . LYS A 1 230 ? 15.464 -10.739 -43.321 1.00 16.89 ? 299 LYS A O 1 ATOM 1742 C CB . LYS A 1 230 ? 12.537 -10.238 -43.755 1.00 16.04 ? 299 LYS A CB 1 ATOM 1743 C CG . LYS A 1 230 ? 11.033 -10.101 -43.456 1.00 16.13 ? 299 LYS A CG 1 ATOM 1744 C CD . LYS A 1 230 ? 10.551 -8.744 -43.870 1.00 14.91 ? 299 LYS A CD 1 ATOM 1745 C CE . LYS A 1 230 ? 9.046 -8.657 -43.955 1.00 14.98 ? 299 LYS A CE 1 ATOM 1746 N NZ . LYS A 1 230 ? 8.669 -7.309 -44.514 1.00 13.88 ? 299 LYS A NZ 1 ATOM 1747 N N . ARG A 1 231 ? 14.793 -12.672 -44.165 1.00 17.34 ? 300 ARG A N 1 ATOM 1748 C CA . ARG A 1 231 ? 16.083 -12.912 -44.820 1.00 17.64 ? 300 ARG A CA 1 ATOM 1749 C C . ARG A 1 231 ? 16.226 -12.007 -46.036 1.00 17.73 ? 300 ARG A C 1 ATOM 1750 O O . ARG A 1 231 ? 15.298 -11.900 -46.818 1.00 17.85 ? 300 ARG A O 1 ATOM 1751 C CB . ARG A 1 231 ? 16.224 -14.362 -45.269 1.00 18.01 ? 300 ARG A CB 1 ATOM 1752 C CG . ARG A 1 231 ? 16.319 -15.350 -44.098 1.00 17.95 ? 300 ARG A CG 1 ATOM 1753 C CD . ARG A 1 231 ? 17.233 -16.525 -44.421 1.00 17.20 ? 300 ARG A CD 1 ATOM 1754 N NE . ARG A 1 231 ? 17.379 -17.350 -43.235 1.00 15.86 ? 300 ARG A NE 1 ATOM 1755 C CZ . ARG A 1 231 ? 18.136 -17.028 -42.195 1.00 18.48 ? 300 ARG A CZ 1 ATOM 1756 N NH1 . ARG A 1 231 ? 18.847 -15.905 -42.205 1.00 18.30 ? 300 ARG A NH1 1 ATOM 1757 N NH2 . ARG A 1 231 ? 18.189 -17.835 -41.133 1.00 20.07 ? 300 ARG A NH2 1 ATOM 1758 N N . PRO A 1 232 ? 17.371 -11.321 -46.161 1.00 17.71 ? 301 PRO A N 1 ATOM 1759 C CA . PRO A 1 232 ? 17.721 -10.616 -47.398 1.00 17.95 ? 301 PRO A CA 1 ATOM 1760 C C . PRO A 1 232 ? 17.918 -11.619 -48.514 1.00 17.46 ? 301 PRO A C 1 ATOM 1761 O O . PRO A 1 232 ? 18.417 -12.714 -48.260 1.00 17.63 ? 301 PRO A O 1 ATOM 1762 C CB . PRO A 1 232 ? 19.037 -9.918 -47.048 1.00 17.92 ? 301 PRO A CB 1 ATOM 1763 C CG . PRO A 1 232 ? 19.035 -9.821 -45.564 1.00 17.99 ? 301 PRO A CG 1 ATOM 1764 C CD . PRO A 1 232 ? 18.344 -11.062 -45.089 1.00 17.98 ? 301 PRO A CD 1 ATOM 1765 N N . PHE A 1 233 ? 17.515 -11.270 -49.728 1.00 17.71 ? 302 PHE A N 1 ATOM 1766 C CA . PHE A 1 233 ? 17.435 -12.266 -50.795 1.00 17.80 ? 302 PHE A CA 1 ATOM 1767 C C . PHE A 1 233 ? 18.094 -11.757 -52.050 1.00 17.89 ? 302 PHE A C 1 ATOM 1768 O O . PHE A 1 233 ? 17.588 -10.830 -52.680 1.00 18.55 ? 302 PHE A O 1 ATOM 1769 C CB . PHE A 1 233 ? 15.962 -12.653 -51.056 1.00 17.75 ? 302 PHE A CB 1 ATOM 1770 C CG . PHE A 1 233 ? 15.783 -13.805 -52.021 1.00 17.94 ? 302 PHE A CG 1 ATOM 1771 C CD1 . PHE A 1 233 ? 15.565 -15.095 -51.553 1.00 17.91 ? 302 PHE A CD1 1 ATOM 1772 C CD2 . PHE A 1 233 ? 15.814 -13.594 -53.407 1.00 17.85 ? 302 PHE A CD2 1 ATOM 1773 C CE1 . PHE A 1 233 ? 15.406 -16.152 -52.442 1.00 17.22 ? 302 PHE A CE1 1 ATOM 1774 C CE2 . PHE A 1 233 ? 15.644 -14.636 -54.304 1.00 16.17 ? 302 PHE A CE2 1 ATOM 1775 C CZ . PHE A 1 233 ? 15.442 -15.920 -53.831 1.00 17.68 ? 302 PHE A CZ 1 ATOM 1776 N N . VAL A 1 234 ? 19.196 -12.389 -52.434 1.00 18.07 ? 303 VAL A N 1 ATOM 1777 C CA . VAL A 1 234 ? 20.004 -11.926 -53.569 1.00 18.51 ? 303 VAL A CA 1 ATOM 1778 C C . VAL A 1 234 ? 19.603 -12.556 -54.896 1.00 18.74 ? 303 VAL A C 1 ATOM 1779 O O . VAL A 1 234 ? 19.454 -13.754 -54.979 1.00 18.57 ? 303 VAL A O 1 ATOM 1780 C CB . VAL A 1 234 ? 21.479 -12.304 -53.356 1.00 18.84 ? 303 VAL A CB 1 ATOM 1781 C CG1 . VAL A 1 234 ? 22.314 -11.782 -54.493 1.00 19.99 ? 303 VAL A CG1 1 ATOM 1782 C CG2 . VAL A 1 234 ? 21.997 -11.817 -51.973 1.00 18.10 ? 303 VAL A CG2 1 ATOM 1783 N N . LYS A 1 235 ? 19.458 -11.753 -55.946 1.00 19.27 ? 304 LYS A N 1 ATOM 1784 C CA . LYS A 1 235 ? 19.368 -12.282 -57.298 1.00 19.22 ? 304 LYS A CA 1 ATOM 1785 C C . LYS A 1 235 ? 20.564 -11.762 -58.044 1.00 19.77 ? 304 LYS A C 1 ATOM 1786 O O . LYS A 1 235 ? 20.718 -10.562 -58.171 1.00 19.82 ? 304 LYS A O 1 ATOM 1787 C CB . LYS A 1 235 ? 18.081 -11.831 -57.968 1.00 19.34 ? 304 LYS A CB 1 ATOM 1788 C CG . LYS A 1 235 ? 16.823 -12.534 -57.444 1.00 18.99 ? 304 LYS A CG 1 ATOM 1789 C CD . LYS A 1 235 ? 15.558 -11.883 -57.971 1.00 19.20 ? 304 LYS A CD 1 ATOM 1790 C CE . LYS A 1 235 ? 14.351 -12.280 -57.175 1.00 20.05 ? 304 LYS A CE 1 ATOM 1791 N NZ . LYS A 1 235 ? 13.115 -11.619 -57.688 1.00 21.34 ? 304 LYS A NZ 1 ATOM 1792 N N . LEU A 1 236 ? 21.433 -12.658 -58.508 1.00 20.40 ? 305 LEU A N 1 ATOM 1793 C CA . LEU A 1 236 ? 22.636 -12.268 -59.231 1.00 20.90 ? 305 LEU A CA 1 ATOM 1794 C C . LEU A 1 236 ? 22.589 -12.841 -60.667 1.00 21.38 ? 305 LEU A C 1 ATOM 1795 O O . LEU A 1 236 ? 22.569 -14.053 -60.865 1.00 21.79 ? 305 LEU A O 1 ATOM 1796 C CB . LEU A 1 236 ? 23.866 -12.779 -58.475 1.00 21.01 ? 305 LEU A CB 1 ATOM 1797 C CG . LEU A 1 236 ? 25.279 -12.262 -58.767 1.00 21.43 ? 305 LEU A CG 1 ATOM 1798 C CD1 . LEU A 1 236 ? 26.243 -12.829 -57.697 1.00 21.40 ? 305 LEU A CD1 1 ATOM 1799 C CD2 . LEU A 1 236 ? 25.744 -12.645 -60.157 1.00 22.36 ? 305 LEU A CD2 1 ATOM 1800 N N . ASN A 1 237 ? 22.552 -11.969 -61.658 1.00 21.53 ? 306 ASN A N 1 ATOM 1801 C CA . ASN A 1 237 ? 22.608 -12.398 -63.056 1.00 22.49 ? 306 ASN A CA 1 ATOM 1802 C C . ASN A 1 237 ? 24.051 -12.647 -63.464 1.00 22.51 ? 306 ASN A C 1 ATOM 1803 O O . ASN A 1 237 ? 24.882 -11.747 -63.414 1.00 22.51 ? 306 ASN A O 1 ATOM 1804 C CB . ASN A 1 237 ? 21.969 -11.330 -63.953 1.00 22.53 ? 306 ASN A CB 1 ATOM 1805 C CG . ASN A 1 237 ? 21.977 -11.709 -65.432 1.00 24.03 ? 306 ASN A CG 1 ATOM 1806 O OD1 . ASN A 1 237 ? 22.978 -12.185 -65.965 1.00 25.81 ? 306 ASN A OD1 1 ATOM 1807 N ND2 . ASN A 1 237 ? 20.856 -11.486 -66.098 1.00 24.93 ? 306 ASN A ND2 1 ATOM 1808 N N . VAL A 1 238 ? 24.351 -13.874 -63.862 1.00 23.42 ? 307 VAL A N 1 ATOM 1809 C CA . VAL A 1 238 ? 25.714 -14.251 -64.236 1.00 24.23 ? 307 VAL A CA 1 ATOM 1810 C C . VAL A 1 238 ? 26.076 -13.944 -65.716 1.00 25.37 ? 307 VAL A C 1 ATOM 1811 O O . VAL A 1 238 ? 27.220 -14.144 -66.122 1.00 24.79 ? 307 VAL A O 1 ATOM 1812 C CB . VAL A 1 238 ? 26.011 -15.764 -63.910 1.00 24.40 ? 307 VAL A CB 1 ATOM 1813 C CG1 . VAL A 1 238 ? 25.847 -16.049 -62.399 1.00 23.37 ? 307 VAL A CG1 1 ATOM 1814 C CG2 . VAL A 1 238 ? 25.132 -16.704 -64.735 1.00 23.86 ? 307 VAL A CG2 1 ATOM 1815 N N . GLU A 1 239 ? 25.121 -13.460 -66.517 1.00 26.68 ? 308 GLU A N 1 ATOM 1816 C CA . GLU A 1 239 ? 25.408 -13.090 -67.923 1.00 27.57 ? 308 GLU A CA 1 ATOM 1817 C C . GLU A 1 239 ? 25.911 -11.656 -68.060 1.00 28.04 ? 308 GLU A C 1 ATOM 1818 O O . GLU A 1 239 ? 26.699 -11.344 -68.964 1.00 28.94 ? 308 GLU A O 1 ATOM 1819 C CB . GLU A 1 239 ? 24.163 -13.257 -68.799 1.00 27.82 ? 308 GLU A CB 1 ATOM 1820 C CG . GLU A 1 239 ? 23.923 -14.677 -69.274 1.00 29.29 ? 308 GLU A CG 1 ATOM 1821 C CD . GLU A 1 239 ? 22.547 -14.872 -69.916 1.00 31.03 ? 308 GLU A CD 1 ATOM 1822 O OE1 . GLU A 1 239 ? 21.870 -13.870 -70.253 1.00 32.63 ? 308 GLU A OE1 1 ATOM 1823 O OE2 . GLU A 1 239 ? 22.131 -16.041 -70.077 1.00 33.01 ? 308 GLU A OE2 1 ATOM 1824 N N . THR A 1 240 ? 25.416 -10.789 -67.180 1.00 28.56 ? 309 THR A N 1 ATOM 1825 C CA . THR A 1 240 ? 25.785 -9.375 -67.129 1.00 28.17 ? 309 THR A CA 1 ATOM 1826 C C . THR A 1 240 ? 26.608 -9.032 -65.887 1.00 28.17 ? 309 THR A C 1 ATOM 1827 O O . THR A 1 240 ? 27.131 -7.911 -65.772 1.00 28.62 ? 309 THR A O 1 ATOM 1828 C CB . THR A 1 240 ? 24.506 -8.517 -67.111 1.00 28.73 ? 309 THR A CB 1 ATOM 1829 O OG1 . THR A 1 240 ? 23.760 -8.783 -65.904 1.00 27.03 ? 309 THR A OG1 1 ATOM 1830 C CG2 . THR A 1 240 ? 23.645 -8.841 -68.349 1.00 27.54 ? 309 THR A CG2 1 ATOM 1831 N N . ASP A 1 241 ? 26.714 -9.992 -64.962 1.00 27.31 ? 310 ASP A N 1 ATOM 1832 C CA . ASP A 1 241 ? 27.479 -9.834 -63.708 1.00 26.73 ? 310 ASP A CA 1 ATOM 1833 C C . ASP A 1 241 ? 26.989 -8.683 -62.820 1.00 25.24 ? 310 ASP A C 1 ATOM 1834 O O . ASP A 1 241 ? 27.769 -7.878 -62.309 1.00 25.32 ? 310 ASP A O 1 ATOM 1835 C CB . ASP A 1 241 ? 28.990 -9.728 -64.001 1.00 26.98 ? 310 ASP A CB 1 ATOM 1836 C CG . ASP A 1 241 ? 29.614 -11.074 -64.335 1.00 27.29 ? 310 ASP A CG 1 ATOM 1837 O OD1 . ASP A 1 241 ? 29.230 -12.079 -63.695 1.00 27.42 ? 310 ASP A OD1 1 ATOM 1838 O OD2 . ASP A 1 241 ? 30.494 -11.129 -65.229 1.00 27.32 ? 310 ASP A OD2 1 ATOM 1839 N N . THR A 1 242 ? 25.682 -8.640 -62.622 1.00 24.09 ? 311 THR A N 1 ATOM 1840 C CA . THR A 1 242 ? 25.010 -7.563 -61.886 1.00 23.09 ? 311 THR A CA 1 ATOM 1841 C C . THR A 1 242 ? 24.209 -8.231 -60.785 1.00 22.26 ? 311 THR A C 1 ATOM 1842 O O . THR A 1 242 ? 23.769 -9.360 -60.954 1.00 22.20 ? 311 THR A O 1 ATOM 1843 C CB . THR A 1 242 ? 24.031 -6.818 -62.815 1.00 22.90 ? 311 THR A CB 1 ATOM 1844 O OG1 . THR A 1 242 ? 23.432 -7.781 -63.683 1.00 24.16 ? 311 THR A OG1 1 ATOM 1845 C CG2 . THR A 1 242 ? 24.744 -5.787 -63.663 1.00 21.51 ? 311 THR A CG2 1 ATOM 1846 N N . ALA A 1 243 ? 23.999 -7.550 -59.672 1.00 21.42 ? 312 ALA A N 1 ATOM 1847 C CA . ALA A 1 243 ? 23.249 -8.147 -58.568 1.00 21.47 ? 312 ALA A CA 1 ATOM 1848 C C . ALA A 1 243 ? 22.309 -7.130 -57.914 1.00 21.55 ? 312 ALA A C 1 ATOM 1849 O O . ALA A 1 243 ? 22.645 -5.930 -57.866 1.00 21.65 ? 312 ALA A O 1 ATOM 1850 C CB . ALA A 1 243 ? 24.201 -8.737 -57.549 1.00 20.83 ? 312 ALA A CB 1 ATOM 1851 N N . GLU A 1 244 ? 21.128 -7.611 -57.473 1.00 21.06 ? 313 GLU A N 1 ATOM 1852 C CA . GLU A 1 244 ? 20.168 -6.820 -56.701 1.00 20.97 ? 313 GLU A CA 1 ATOM 1853 C C . GLU A 1 244 ? 19.678 -7.585 -55.470 1.00 20.33 ? 313 GLU A C 1 ATOM 1854 O O . GLU A 1 244 ? 19.312 -8.744 -55.584 1.00 19.68 ? 313 GLU A O 1 ATOM 1855 C CB . GLU A 1 244 ? 18.947 -6.423 -57.545 1.00 21.09 ? 313 GLU A CB 1 ATOM 1856 C CG . GLU A 1 244 ? 17.922 -5.579 -56.725 1.00 22.83 ? 313 GLU A CG 1 ATOM 1857 C CD . GLU A 1 244 ? 16.739 -5.030 -57.521 1.00 24.87 ? 313 GLU A CD 1 ATOM 1858 O OE1 . GLU A 1 244 ? 16.689 -5.209 -58.752 1.00 25.10 ? 313 GLU A OE1 1 ATOM 1859 O OE2 . GLU A 1 244 ? 15.837 -4.413 -56.892 1.00 26.02 ? 313 GLU A OE2 1 ATOM 1860 N N . ILE A 1 245 ? 19.650 -6.915 -54.314 1.00 20.20 ? 314 ILE A N 1 ATOM 1861 C CA . ILE A 1 245 ? 19.107 -7.482 -53.058 1.00 19.76 ? 314 ILE A CA 1 ATOM 1862 C C . ILE A 1 245 ? 17.790 -6.813 -52.608 1.00 20.10 ? 314 ILE A C 1 ATOM 1863 O O . ILE A 1 245 ? 17.707 -5.588 -52.589 1.00 19.69 ? 314 ILE A O 1 ATOM 1864 C CB . ILE A 1 245 ? 20.103 -7.298 -51.911 1.00 19.17 ? 314 ILE A CB 1 ATOM 1865 C CG1 . ILE A 1 245 ? 21.497 -7.754 -52.343 1.00 18.43 ? 314 ILE A CG1 1 ATOM 1866 C CG2 . ILE A 1 245 ? 19.640 -8.093 -50.669 1.00 18.75 ? 314 ILE A CG2 1 ATOM 1867 C CD1 . ILE A 1 245 ? 22.565 -7.682 -51.253 1.00 15.54 ? 314 ILE A CD1 1 ATOM 1868 N N . ARG A 1 246 ? 16.779 -7.626 -52.251 1.00 21.10 ? 315 ARG A N 1 ATOM 1869 C CA . ARG A 1 246 ? 15.583 -7.190 -51.466 1.00 21.04 ? 315 ARG A CA 1 ATOM 1870 C C . ARG A 1 246 ? 15.265 -8.233 -50.404 1.00 20.89 ? 315 ARG A C 1 ATOM 1871 O O . ARG A 1 246 ? 15.671 -9.388 -50.548 1.00 21.40 ? 315 ARG A O 1 ATOM 1872 C CB . ARG A 1 246 ? 14.315 -7.040 -52.316 1.00 21.23 ? 315 ARG A CB 1 ATOM 1873 C CG . ARG A 1 246 ? 14.419 -6.169 -53.566 1.00 24.49 ? 315 ARG A CG 1 ATOM 1874 C CD . ARG A 1 246 ? 14.354 -4.694 -53.254 1.00 27.20 ? 315 ARG A CD 1 ATOM 1875 N NE . ARG A 1 246 ? 14.856 -3.908 -54.383 1.00 29.76 ? 315 ARG A NE 1 ATOM 1876 C CZ . ARG A 1 246 ? 15.296 -2.651 -54.311 1.00 30.17 ? 315 ARG A CZ 1 ATOM 1877 N NH1 . ARG A 1 246 ? 15.314 -1.986 -53.151 1.00 30.53 ? 315 ARG A NH1 1 ATOM 1878 N NH2 . ARG A 1 246 ? 15.728 -2.056 -55.414 1.00 29.97 ? 315 ARG A NH2 1 ATOM 1879 N N . LEU A 1 247 ? 14.513 -7.835 -49.370 1.00 19.76 ? 316 LEU A N 1 ATOM 1880 C CA . LEU A 1 247 ? 14.066 -8.757 -48.321 1.00 20.07 ? 316 LEU A CA 1 ATOM 1881 C C . LEU A 1 247 ? 13.011 -9.754 -48.814 1.00 19.76 ? 316 LEU A C 1 ATOM 1882 O O . LEU A 1 247 ? 12.212 -9.437 -49.680 1.00 20.69 ? 316 LEU A O 1 ATOM 1883 C CB . LEU A 1 247 ? 13.474 -7.990 -47.108 1.00 19.12 ? 316 LEU A CB 1 ATOM 1884 C CG . LEU A 1 247 ? 14.432 -7.160 -46.270 1.00 18.96 ? 316 LEU A CG 1 ATOM 1885 C CD1 . LEU A 1 247 ? 13.703 -6.464 -45.079 1.00 17.50 ? 316 LEU A CD1 1 ATOM 1886 C CD2 . LEU A 1 247 ? 15.595 -8.022 -45.789 1.00 17.98 ? 316 LEU A CD2 1 ATOM 1887 N N . MET A 1 248 ? 13.002 -10.954 -48.246 1.00 19.89 ? 317 MET A N 1 ATOM 1888 C CA . MET A 1 248 ? 11.956 -11.934 -48.552 1.00 19.92 ? 317 MET A CA 1 ATOM 1889 C C . MET A 1 248 ? 10.640 -11.451 -47.980 1.00 20.01 ? 317 MET A C 1 ATOM 1890 O O . MET A 1 248 ? 10.580 -10.932 -46.854 1.00 19.64 ? 317 MET A O 1 ATOM 1891 C CB . MET A 1 248 ? 12.258 -13.304 -47.969 1.00 20.36 ? 317 MET A CB 1 ATOM 1892 C CG . MET A 1 248 ? 13.512 -13.975 -48.467 1.00 19.89 ? 317 MET A CG 1 ATOM 1893 S SD . MET A 1 248 ? 13.538 -15.648 -47.842 1.00 20.17 ? 317 MET A SD 1 ATOM 1894 C CE . MET A 1 248 ? 12.355 -16.463 -48.910 1.00 22.43 ? 317 MET A CE 1 ATOM 1895 N N . CYS A 1 249 ? 9.583 -11.587 -48.766 1.00 20.11 ? 318 CYS A N 1 ATOM 1896 C CA . CYS A 1 249 ? 8.319 -10.944 -48.407 1.00 20.46 ? 318 CYS A CA 1 ATOM 1897 C C . CYS A 1 249 ? 7.442 -11.864 -47.580 1.00 19.19 ? 318 CYS A C 1 ATOM 1898 O O . CYS A 1 249 ? 6.501 -11.394 -46.960 1.00 19.29 ? 318 CYS A O 1 ATOM 1899 C CB . CYS A 1 249 ? 7.531 -10.471 -49.641 1.00 20.44 ? 318 CYS A CB 1 ATOM 1900 S SG . CYS A 1 249 ? 6.108 -9.453 -49.132 1.00 23.80 ? 318 CYS A SG 1 ATOM 1901 N N . THR A 1 250 ? 7.742 -13.160 -47.595 1.00 18.33 ? 319 THR A N 1 ATOM 1902 C CA . THR A 1 250 ? 6.907 -14.145 -46.909 1.00 18.17 ? 319 THR A CA 1 ATOM 1903 C C . THR A 1 250 ? 6.697 -13.819 -45.422 1.00 18.73 ? 319 THR A C 1 ATOM 1904 O O . THR A 1 250 ? 7.565 -13.227 -44.755 1.00 17.98 ? 319 THR A O 1 ATOM 1905 C CB . THR A 1 250 ? 7.450 -15.600 -47.102 1.00 18.15 ? 319 THR A CB 1 ATOM 1906 O OG1 . THR A 1 250 ? 6.584 -16.535 -46.454 1.00 16.70 ? 319 THR A OG1 1 ATOM 1907 C CG2 . THR A 1 250 ? 8.899 -15.762 -46.593 1.00 17.75 ? 319 THR A CG2 1 ATOM 1908 N N . GLU A 1 251 ? 5.509 -14.176 -44.939 1.00 19.55 ? 320 GLU A N 1 ATOM 1909 C CA . GLU A 1 251 ? 5.147 -14.064 -43.521 1.00 20.41 ? 320 GLU A CA 1 ATOM 1910 C C . GLU A 1 251 ? 5.899 -15.088 -42.666 1.00 20.60 ? 320 GLU A C 1 ATOM 1911 O O . GLU A 1 251 ? 5.982 -14.954 -41.425 1.00 21.00 ? 320 GLU A O 1 ATOM 1912 C CB . GLU A 1 251 ? 3.625 -14.228 -43.326 1.00 20.66 ? 320 GLU A CB 1 ATOM 1913 C CG . GLU A 1 251 ? 3.040 -15.550 -43.862 1.00 23.34 ? 320 GLU A CG 1 ATOM 1914 C CD . GLU A 1 251 ? 1.757 -15.993 -43.159 1.00 28.75 ? 320 GLU A CD 1 ATOM 1915 O OE1 . GLU A 1 251 ? 0.693 -16.010 -43.821 1.00 33.42 ? 320 GLU A OE1 1 ATOM 1916 O OE2 . GLU A 1 251 ? 1.803 -16.333 -41.953 1.00 30.70 ? 320 GLU A OE2 1 ATOM 1917 N N . THR A 1 252 ? 6.431 -16.117 -43.332 1.00 20.64 ? 321 THR A N 1 ATOM 1918 C CA . THR A 1 252 ? 7.217 -17.160 -42.691 1.00 20.84 ? 321 THR A CA 1 ATOM 1919 C C . THR A 1 252 ? 8.672 -16.686 -42.441 1.00 20.94 ? 321 THR A C 1 ATOM 1920 O O . THR A 1 252 ? 9.607 -17.127 -43.117 1.00 20.90 ? 321 THR A O 1 ATOM 1921 C CB . THR A 1 252 ? 7.169 -18.451 -43.564 1.00 21.02 ? 321 THR A CB 1 ATOM 1922 O OG1 . THR A 1 252 ? 5.812 -18.676 -43.976 1.00 21.43 ? 321 THR A OG1 1 ATOM 1923 C CG2 . THR A 1 252 ? 7.681 -19.681 -42.794 1.00 21.30 ? 321 THR A CG2 1 ATOM 1924 N N . TYR A 1 253 ? 8.858 -15.801 -41.449 1.00 20.82 ? 322 TYR A N 1 ATOM 1925 C CA . TYR A 1 253 ? 10.183 -15.213 -41.166 1.00 20.59 ? 322 TYR A CA 1 ATOM 1926 C C . TYR A 1 253 ? 11.146 -16.355 -40.818 1.00 20.15 ? 322 TYR A C 1 ATOM 1927 O O . TYR A 1 253 ? 10.786 -17.216 -40.021 1.00 19.93 ? 322 TYR A O 1 ATOM 1928 C CB . TYR A 1 253 ? 10.107 -14.162 -40.034 1.00 20.88 ? 322 TYR A CB 1 ATOM 1929 C CG . TYR A 1 253 ? 8.908 -13.242 -40.175 1.00 21.38 ? 322 TYR A CG 1 ATOM 1930 C CD1 . TYR A 1 253 ? 8.596 -12.689 -41.415 1.00 21.86 ? 322 TYR A CD1 1 ATOM 1931 C CD2 . TYR A 1 253 ? 8.064 -12.967 -39.103 1.00 20.28 ? 322 TYR A CD2 1 ATOM 1932 C CE1 . TYR A 1 253 ? 7.518 -11.894 -41.593 1.00 20.65 ? 322 TYR A CE1 1 ATOM 1933 C CE2 . TYR A 1 253 ? 6.954 -12.154 -39.279 1.00 20.66 ? 322 TYR A CE2 1 ATOM 1934 C CZ . TYR A 1 253 ? 6.684 -11.615 -40.547 1.00 21.28 ? 322 TYR A CZ 1 ATOM 1935 O OH . TYR A 1 253 ? 5.587 -10.787 -40.801 1.00 18.24 ? 322 TYR A OH 1 ATOM 1936 N N . LEU A 1 254 ? 12.327 -16.379 -41.455 1.00 19.99 ? 323 LEU A N 1 ATOM 1937 C CA . LEU A 1 254 ? 13.255 -17.542 -41.434 1.00 19.40 ? 323 LEU A CA 1 ATOM 1938 C C . LEU A 1 254 ? 14.466 -17.357 -40.533 1.00 19.45 ? 323 LEU A C 1 ATOM 1939 O O . LEU A 1 254 ? 15.224 -18.297 -40.297 1.00 19.42 ? 323 LEU A O 1 ATOM 1940 C CB . LEU A 1 254 ? 13.754 -17.853 -42.850 1.00 19.34 ? 323 LEU A CB 1 ATOM 1941 C CG . LEU A 1 254 ? 12.821 -18.548 -43.869 1.00 18.70 ? 323 LEU A CG 1 ATOM 1942 C CD1 . LEU A 1 254 ? 13.509 -18.617 -45.245 1.00 17.49 ? 323 LEU A CD1 1 ATOM 1943 C CD2 . LEU A 1 254 ? 12.418 -19.950 -43.413 1.00 16.66 ? 323 LEU A CD2 1 ATOM 1944 N N . ASP A 1 255 ? 14.666 -16.142 -40.048 1.00 19.18 ? 324 ASP A N 1 ATOM 1945 C CA . ASP A 1 255 ? 15.730 -15.863 -39.114 1.00 19.46 ? 324 ASP A CA 1 ATOM 1946 C C . ASP A 1 255 ? 15.301 -16.199 -37.674 1.00 19.40 ? 324 ASP A C 1 ATOM 1947 O O . ASP A 1 255 ? 14.116 -16.393 -37.371 1.00 19.31 ? 324 ASP A O 1 ATOM 1948 C CB . ASP A 1 255 ? 16.144 -14.389 -39.230 1.00 19.53 ? 324 ASP A CB 1 ATOM 1949 C CG . ASP A 1 255 ? 17.642 -14.186 -39.134 1.00 19.62 ? 324 ASP A CG 1 ATOM 1950 O OD1 . ASP A 1 255 ? 18.364 -15.198 -38.984 1.00 18.81 ? 324 ASP A OD1 1 ATOM 1951 O OD2 . ASP A 1 255 ? 18.083 -13.013 -39.222 1.00 19.01 ? 324 ASP A OD2 1 ATOM 1952 N N . THR A 1 256 ? 16.293 -16.274 -36.799 1.00 20.30 ? 325 THR A N 1 ATOM 1953 C CA . THR A 1 256 ? 16.091 -16.456 -35.348 1.00 20.25 ? 325 THR A CA 1 ATOM 1954 C C . THR A 1 256 ? 17.106 -15.570 -34.657 1.00 20.93 ? 325 THR A C 1 ATOM 1955 O O . THR A 1 256 ? 18.292 -15.610 -35.023 1.00 21.60 ? 325 THR A O 1 ATOM 1956 C CB . THR A 1 256 ? 16.334 -17.885 -34.888 1.00 20.21 ? 325 THR A CB 1 ATOM 1957 O OG1 . THR A 1 256 ? 15.569 -18.788 -35.699 1.00 19.69 ? 325 THR A OG1 1 ATOM 1958 C CG2 . THR A 1 256 ? 15.960 -18.046 -33.364 1.00 19.38 ? 325 THR A CG2 1 ATOM 1959 N N . PRO A 1 257 ? 16.663 -14.755 -33.686 1.00 21.10 ? 326 PRO A N 1 ATOM 1960 C CA . PRO A 1 257 ? 15.272 -14.669 -33.272 1.00 21.76 ? 326 PRO A CA 1 ATOM 1961 C C . PRO A 1 257 ? 14.363 -14.038 -34.313 1.00 21.63 ? 326 PRO A C 1 ATOM 1962 O O . PRO A 1 257 ? 14.831 -13.447 -35.277 1.00 21.39 ? 326 PRO A O 1 ATOM 1963 C CB . PRO A 1 257 ? 15.309 -13.796 -32.005 1.00 21.57 ? 326 PRO A CB 1 ATOM 1964 C CG . PRO A 1 257 ? 16.729 -13.712 -31.615 1.00 22.03 ? 326 PRO A CG 1 ATOM 1965 C CD . PRO A 1 257 ? 17.511 -13.862 -32.891 1.00 21.61 ? 326 PRO A CD 1 ATOM 1966 N N . ARG A 1 258 ? 13.064 -14.208 -34.090 1.00 22.13 ? 327 ARG A N 1 ATOM 1967 C CA . ARG A 1 258 ? 12.021 -13.616 -34.907 1.00 22.33 ? 327 ARG A CA 1 ATOM 1968 C C . ARG A 1 258 ? 10.766 -13.421 -34.059 1.00 22.74 ? 327 ARG A C 1 ATOM 1969 O O . ARG A 1 258 ? 10.659 -14.004 -32.971 1.00 22.63 ? 327 ARG A O 1 ATOM 1970 C CB . ARG A 1 258 ? 11.716 -14.509 -36.117 1.00 22.13 ? 327 ARG A CB 1 ATOM 1971 C CG . ARG A 1 258 ? 11.325 -15.945 -35.756 1.00 21.33 ? 327 ARG A CG 1 ATOM 1972 C CD . ARG A 1 258 ? 10.786 -16.711 -36.966 1.00 18.33 ? 327 ARG A CD 1 ATOM 1973 N NE . ARG A 1 258 ? 10.280 -18.036 -36.615 1.00 16.96 ? 327 ARG A NE 1 ATOM 1974 C CZ . ARG A 1 258 ? 11.052 -19.082 -36.299 1.00 19.16 ? 327 ARG A CZ 1 ATOM 1975 N NH1 . ARG A 1 258 ? 12.379 -18.972 -36.290 1.00 20.99 ? 327 ARG A NH1 1 ATOM 1976 N NH2 . ARG A 1 258 ? 10.504 -20.256 -36.007 1.00 17.99 ? 327 ARG A NH2 1 ATOM 1977 N N . PRO A 1 259 ? 9.824 -12.588 -34.548 1.00 23.54 ? 328 PRO A N 1 ATOM 1978 C CA . PRO A 1 259 ? 8.457 -12.495 -34.015 1.00 24.11 ? 328 PRO A CA 1 ATOM 1979 C C . PRO A 1 259 ? 7.545 -13.517 -34.698 1.00 24.27 ? 328 PRO A C 1 ATOM 1980 O O . PRO A 1 259 ? 8.004 -14.204 -35.604 1.00 25.02 ? 328 PRO A O 1 ATOM 1981 C CB . PRO A 1 259 ? 8.054 -11.069 -34.375 1.00 23.77 ? 328 PRO A CB 1 ATOM 1982 C CG . PRO A 1 259 ? 8.763 -10.807 -35.637 1.00 23.76 ? 328 PRO A CG 1 ATOM 1983 C CD . PRO A 1 259 ? 10.027 -11.627 -35.647 1.00 23.58 ? 328 PRO A CD 1 ATOM 1984 N N . ASP A 1 260 ? 6.291 -13.630 -34.252 1.00 24.54 ? 329 ASP A N 1 ATOM 1985 C CA . ASP A 1 260 ? 5.329 -14.583 -34.813 1.00 24.76 ? 329 ASP A CA 1 ATOM 1986 C C . ASP A 1 260 ? 5.107 -14.299 -36.290 1.00 24.87 ? 329 ASP A C 1 ATOM 1987 O O . ASP A 1 260 ? 5.163 -13.153 -36.724 1.00 24.41 ? 329 ASP A O 1 ATOM 1988 C CB . ASP A 1 260 ? 3.988 -14.511 -34.060 1.00 25.39 ? 329 ASP A CB 1 ATOM 1989 C CG . ASP A 1 260 ? 4.114 -14.879 -32.573 1.00 26.82 ? 329 ASP A CG 1 ATOM 1990 O OD1 . ASP A 1 260 ? 5.200 -15.322 -32.166 1.00 29.14 ? 329 ASP A OD1 1 ATOM 1991 O OD2 . ASP A 1 260 ? 3.132 -14.716 -31.799 1.00 30.26 ? 329 ASP A OD2 1 ATOM 1992 N N . ASP A 1 261 ? 4.892 -15.348 -37.070 1.00 25.06 ? 330 ASP A N 1 ATOM 1993 C CA . ASP A 1 261 ? 4.726 -15.197 -38.506 1.00 25.32 ? 330 ASP A CA 1 ATOM 1994 C C . ASP A 1 261 ? 3.681 -14.149 -38.837 1.00 25.74 ? 330 ASP A C 1 ATOM 1995 O O . ASP A 1 261 ? 2.630 -14.092 -38.212 1.00 25.78 ? 330 ASP A O 1 ATOM 1996 C CB . ASP A 1 261 ? 4.243 -16.498 -39.128 1.00 25.12 ? 330 ASP A CB 1 ATOM 1997 C CG . ASP A 1 261 ? 5.284 -17.553 -39.147 1.00 24.65 ? 330 ASP A CG 1 ATOM 1998 O OD1 . ASP A 1 261 ? 6.485 -17.286 -38.882 1.00 24.34 ? 330 ASP A OD1 1 ATOM 1999 O OD2 . ASP A 1 261 ? 4.883 -18.676 -39.452 1.00 23.44 ? 330 ASP A OD2 1 ATOM 2000 N N . GLY A 1 262 ? 3.958 -13.351 -39.853 1.00 26.41 ? 331 GLY A N 1 ATOM 2001 C CA . GLY A 1 262 ? 2.977 -12.401 -40.371 1.00 26.68 ? 331 GLY A CA 1 ATOM 2002 C C . GLY A 1 262 ? 2.742 -11.160 -39.541 1.00 27.06 ? 331 GLY A C 1 ATOM 2003 O O . GLY A 1 262 ? 1.902 -10.337 -39.915 1.00 27.40 ? 331 GLY A O 1 ATOM 2004 N N . SER A 1 263 ? 3.471 -11.014 -38.427 1.00 27.08 ? 332 SER A N 1 ATOM 2005 C CA . SER A 1 263 ? 3.247 -9.913 -37.480 1.00 26.79 ? 332 SER A CA 1 ATOM 2006 C C . SER A 1 263 ? 4.089 -8.666 -37.809 1.00 27.14 ? 332 SER A C 1 ATOM 2007 O O . SER A 1 263 ? 3.879 -7.605 -37.230 1.00 26.15 ? 332 SER A O 1 ATOM 2008 C CB . SER A 1 263 ? 3.525 -10.368 -36.045 1.00 26.09 ? 332 SER A CB 1 ATOM 2009 O OG . SER A 1 263 ? 4.912 -10.526 -35.830 1.00 25.18 ? 332 SER A OG 1 ATOM 2010 N N . ILE A 1 264 ? 5.052 -8.784 -38.718 1.00 28.05 ? 333 ILE A N 1 ATOM 2011 C CA . ILE A 1 264 ? 5.729 -7.580 -39.203 1.00 28.84 ? 333 ILE A CA 1 ATOM 2012 C C . ILE A 1 264 ? 4.746 -6.843 -40.129 1.00 29.35 ? 333 ILE A C 1 ATOM 2013 O O . ILE A 1 264 ? 4.355 -7.370 -41.185 1.00 28.93 ? 333 ILE A O 1 ATOM 2014 C CB . ILE A 1 264 ? 7.031 -7.860 -39.947 1.00 28.89 ? 333 ILE A CB 1 ATOM 2015 C CG1 . ILE A 1 264 ? 8.030 -8.616 -39.067 1.00 29.20 ? 333 ILE A CG1 1 ATOM 2016 C CG2 . ILE A 1 264 ? 7.643 -6.552 -40.410 1.00 29.07 ? 333 ILE A CG2 1 ATOM 2017 C CD1 . ILE A 1 264 ? 9.272 -9.053 -39.817 1.00 28.29 ? 333 ILE A CD1 1 ATOM 2018 N N . THR A 1 265 ? 4.333 -5.655 -39.685 1.00 29.93 ? 334 THR A N 1 ATOM 2019 C CA . THR A 1 265 ? 3.340 -4.831 -40.377 1.00 31.00 ? 334 THR A CA 1 ATOM 2020 C C . THR A 1 265 ? 4.015 -3.971 -41.448 1.00 30.82 ? 334 THR A C 1 ATOM 2021 O O . THR A 1 265 ? 5.072 -3.406 -41.190 1.00 31.55 ? 334 THR A O 1 ATOM 2022 C CB . THR A 1 265 ? 2.620 -3.886 -39.363 1.00 31.10 ? 334 THR A CB 1 ATOM 2023 O OG1 . THR A 1 265 ? 3.574 -2.997 -38.757 1.00 32.53 ? 334 THR A OG1 1 ATOM 2024 C CG2 . THR A 1 265 ? 1.927 -4.689 -38.260 1.00 31.09 ? 334 THR A CG2 1 ATOM 2025 N N . GLY A 1 266 ? 3.414 -3.871 -42.631 1.00 30.53 ? 335 GLY A N 1 ATOM 2026 C CA . GLY A 1 266 ? 3.941 -2.999 -43.707 1.00 30.42 ? 335 GLY A CA 1 ATOM 2027 C C . GLY A 1 266 ? 4.017 -3.677 -45.073 1.00 29.99 ? 335 GLY A C 1 ATOM 2028 O O . GLY A 1 266 ? 3.556 -4.796 -45.232 1.00 28.84 ? 335 GLY A O 1 ATOM 2029 N N . PRO A 1 267 ? 4.589 -2.993 -46.076 1.00 30.32 ? 336 PRO A N 1 ATOM 2030 C CA . PRO A 1 267 ? 4.766 -3.633 -47.382 1.00 30.32 ? 336 PRO A CA 1 ATOM 2031 C C . PRO A 1 267 ? 5.945 -4.607 -47.322 1.00 30.15 ? 336 PRO A C 1 ATOM 2032 O O . PRO A 1 267 ? 6.446 -4.890 -46.235 1.00 30.56 ? 336 PRO A O 1 ATOM 2033 C CB . PRO A 1 267 ? 5.047 -2.455 -48.308 1.00 30.25 ? 336 PRO A CB 1 ATOM 2034 C CG . PRO A 1 267 ? 5.787 -1.511 -47.447 1.00 30.92 ? 336 PRO A CG 1 ATOM 2035 C CD . PRO A 1 267 ? 5.083 -1.604 -46.094 1.00 30.82 ? 336 PRO A CD 1 ATOM 2036 N N . CYS A 1 268 ? 6.391 -5.113 -48.464 1.00 29.74 ? 337 CYS A N 1 ATOM 2037 C CA . CYS A 1 268 ? 7.361 -6.209 -48.466 1.00 29.49 ? 337 CYS A CA 1 ATOM 2038 C C . CYS A 1 268 ? 8.705 -5.867 -47.832 1.00 29.16 ? 337 CYS A C 1 ATOM 2039 O O . CYS A 1 268 ? 9.386 -6.749 -47.289 1.00 28.89 ? 337 CYS A O 1 ATOM 2040 C CB . CYS A 1 268 ? 7.566 -6.759 -49.883 1.00 28.95 ? 337 CYS A CB 1 ATOM 2041 S SG . CYS A 1 268 ? 6.196 -7.835 -50.411 1.00 28.21 ? 337 CYS A SG 1 ATOM 2042 N N . GLU A 1 269 ? 9.059 -4.594 -47.863 1.00 28.82 ? 338 GLU A N 1 ATOM 2043 C CA . GLU A 1 269 ? 10.343 -4.175 -47.407 1.00 29.37 ? 338 GLU A CA 1 ATOM 2044 C C . GLU A 1 269 ? 10.430 -3.759 -45.905 1.00 29.29 ? 338 GLU A C 1 ATOM 2045 O O . GLU A 1 269 ? 11.525 -3.512 -45.435 1.00 29.51 ? 338 GLU A O 1 ATOM 2046 C CB . GLU A 1 269 ? 10.870 -3.080 -48.354 1.00 29.99 ? 338 GLU A CB 1 ATOM 2047 C CG . GLU A 1 269 ? 10.186 -1.704 -48.281 1.00 31.94 ? 338 GLU A CG 1 ATOM 2048 C CD . GLU A 1 269 ? 8.965 -1.529 -49.174 1.00 34.79 ? 338 GLU A CD 1 ATOM 2049 O OE1 . GLU A 1 269 ? 8.446 -2.510 -49.762 1.00 38.00 ? 338 GLU A OE1 1 ATOM 2050 O OE2 . GLU A 1 269 ? 8.506 -0.373 -49.270 1.00 37.39 ? 338 GLU A OE2 1 ATOM 2051 N N . SER A 1 270 ? 9.327 -3.703 -45.155 1.00 28.95 ? 339 SER A N 1 ATOM 2052 C CA . SER A 1 270 ? 9.393 -3.315 -43.718 1.00 29.54 ? 339 SER A CA 1 ATOM 2053 C C . SER A 1 270 ? 10.246 -4.259 -42.890 1.00 29.82 ? 339 SER A C 1 ATOM 2054 O O . SER A 1 270 ? 10.276 -5.448 -43.155 1.00 29.80 ? 339 SER A O 1 ATOM 2055 C CB . SER A 1 270 ? 8.008 -3.295 -43.068 1.00 29.28 ? 339 SER A CB 1 ATOM 2056 O OG . SER A 1 270 ? 7.154 -2.347 -43.680 1.00 31.02 ? 339 SER A OG 1 ATOM 2057 N N . ASN A 1 271 ? 10.866 -3.731 -41.838 1.00 30.71 ? 340 ASN A N 1 ATOM 2058 C CA . ASN A 1 271 ? 11.814 -4.493 -41.029 1.00 31.02 ? 340 ASN A CA 1 ATOM 2059 C C . ASN A 1 271 ? 11.195 -5.501 -40.012 1.00 31.33 ? 340 ASN A C 1 ATOM 2060 O O . ASN A 1 271 ? 11.590 -6.668 -40.029 1.00 31.39 ? 340 ASN A O 1 ATOM 2061 C CB . ASN A 1 271 ? 12.880 -3.567 -40.423 1.00 31.11 ? 340 ASN A CB 1 ATOM 2062 C CG . ASN A 1 271 ? 13.966 -3.155 -41.437 1.00 31.98 ? 340 ASN A CG 1 ATOM 2063 O OD1 . ASN A 1 271 ? 13.962 -3.577 -42.595 1.00 33.06 ? 340 ASN A OD1 1 ATOM 2064 N ND2 . ASN A 1 271 ? 14.901 -2.325 -40.990 1.00 33.19 ? 340 ASN A ND2 1 ATOM 2065 N N . GLY A 1 272 ? 10.322 -5.134 -39.079 1.00 31.58 ? 341 GLY A N 1 ATOM 2066 C CA . GLY A 1 272 ? 10.358 -3.941 -38.308 1.00 31.95 ? 341 GLY A CA 1 ATOM 2067 C C . GLY A 1 272 ? 11.043 -4.416 -37.038 1.00 32.09 ? 341 GLY A C 1 ATOM 2068 O O . GLY A 1 272 ? 12.235 -4.182 -36.871 1.00 32.55 ? 341 GLY A O 1 ATOM 2069 N N . ASP A 1 273 ? 10.327 -5.166 -36.199 1.00 32.24 ? 342 ASP A N 1 ATOM 2070 C CA . ASP A 1 273 ? 10.805 -5.516 -34.844 1.00 32.54 ? 342 ASP A CA 1 ATOM 2071 C C . ASP A 1 273 ? 11.310 -6.939 -34.551 1.00 32.36 ? 342 ASP A C 1 ATOM 2072 O O . ASP A 1 273 ? 11.223 -7.829 -35.390 1.00 32.41 ? 342 ASP A O 1 ATOM 2073 C CB . ASP A 1 273 ? 9.739 -5.147 -33.811 1.00 32.91 ? 342 ASP A CB 1 ATOM 2074 C CG . ASP A 1 273 ? 10.120 -3.942 -33.029 1.00 33.98 ? 342 ASP A CG 1 ATOM 2075 O OD1 . ASP A 1 273 ? 11.244 -3.958 -32.482 1.00 36.89 ? 342 ASP A OD1 1 ATOM 2076 O OD2 . ASP A 1 273 ? 9.325 -2.980 -32.983 1.00 34.95 ? 342 ASP A OD2 1 ATOM 2077 N N . LYS A 1 274 ? 11.814 -7.114 -33.319 1.00 32.06 ? 343 LYS A N 1 ATOM 2078 C CA . LYS A 1 274 ? 12.619 -8.276 -32.869 1.00 31.85 ? 343 LYS A CA 1 ATOM 2079 C C . LYS A 1 274 ? 13.396 -8.955 -34.003 1.00 31.28 ? 343 LYS A C 1 ATOM 2080 O O . LYS A 1 274 ? 13.190 -10.139 -34.324 1.00 31.34 ? 343 LYS A O 1 ATOM 2081 C CB . LYS A 1 274 ? 11.795 -9.270 -32.031 1.00 31.94 ? 343 LYS A CB 1 ATOM 2082 C CG . LYS A 1 274 ? 12.596 -10.523 -31.550 1.00 33.36 ? 343 LYS A CG 1 ATOM 2083 C CD . LYS A 1 274 ? 12.410 -10.894 -30.039 1.00 34.17 ? 343 LYS A CD 1 ATOM 2084 C CE . LYS A 1 274 ? 12.788 -12.352 -29.726 1.00 33.34 ? 343 LYS A CE 1 ATOM 2085 N NZ . LYS A 1 274 ? 11.823 -13.413 -30.267 1.00 31.93 ? 343 LYS A NZ 1 ATOM 2086 N N . GLY A 1 275 ? 14.296 -8.161 -34.589 1.00 30.18 ? 344 GLY A N 1 ATOM 2087 C CA . GLY A 1 275 ? 15.120 -8.558 -35.721 1.00 28.74 ? 344 GLY A CA 1 ATOM 2088 C C . GLY A 1 275 ? 16.608 -8.393 -35.468 1.00 27.41 ? 344 GLY A C 1 ATOM 2089 O O . GLY A 1 275 ? 17.391 -8.521 -36.400 1.00 26.38 ? 344 GLY A O 1 ATOM 2090 N N . SER A 1 276 ? 17.019 -8.138 -34.221 1.00 26.04 ? 345 SER A N 1 ATOM 2091 C CA . SER A 1 276 ? 18.455 -8.143 -33.889 1.00 25.18 ? 345 SER A CA 1 ATOM 2092 C C . SER A 1 276 ? 18.936 -9.581 -33.752 1.00 23.61 ? 345 SER A C 1 ATOM 2093 O O . SER A 1 276 ? 18.154 -10.497 -33.555 1.00 23.32 ? 345 SER A O 1 ATOM 2094 C CB . SER A 1 276 ? 18.772 -7.324 -32.616 1.00 25.46 ? 345 SER A CB 1 ATOM 2095 O OG . SER A 1 276 ? 17.797 -7.523 -31.603 1.00 26.95 ? 345 SER A OG 1 ATOM 2096 N N . GLY A 1 277 ? 20.238 -9.780 -33.892 1.00 22.67 ? 346 GLY A N 1 ATOM 2097 C CA . GLY A 1 277 ? 20.789 -11.121 -33.965 1.00 21.55 ? 346 GLY A CA 1 ATOM 2098 C C . GLY A 1 277 ? 20.305 -11.845 -35.219 1.00 20.71 ? 346 GLY A C 1 ATOM 2099 O O . GLY A 1 277 ? 19.689 -11.247 -36.105 1.00 20.38 ? 346 GLY A O 1 ATOM 2100 N N . GLY A 1 278 ? 20.578 -13.137 -35.304 1.00 19.28 ? 347 GLY A N 1 ATOM 2101 C CA . GLY A 1 278 ? 20.250 -13.866 -36.518 1.00 18.81 ? 347 GLY A CA 1 ATOM 2102 C C . GLY A 1 278 ? 20.927 -15.214 -36.552 1.00 18.24 ? 347 GLY A C 1 ATOM 2103 O O . GLY A 1 278 ? 21.545 -15.658 -35.557 1.00 17.98 ? 347 GLY A O 1 ATOM 2104 N N . ILE A 1 279 ? 20.804 -15.858 -37.705 1.00 16.94 ? 348 ILE A N 1 ATOM 2105 C CA . ILE A 1 279 ? 21.359 -17.163 -37.927 1.00 15.97 ? 348 ILE A CA 1 ATOM 2106 C C . ILE A 1 279 ? 21.449 -17.436 -39.453 1.00 15.89 ? 348 ILE A C 1 ATOM 2107 O O . ILE A 1 279 ? 20.610 -16.968 -40.213 1.00 14.80 ? 348 ILE A O 1 ATOM 2108 C CB . ILE A 1 279 ? 20.520 -18.222 -37.160 1.00 15.79 ? 348 ILE A CB 1 ATOM 2109 C CG1 . ILE A 1 279 ? 21.308 -19.525 -36.977 1.00 15.96 ? 348 ILE A CG1 1 ATOM 2110 C CG2 . ILE A 1 279 ? 19.116 -18.465 -37.820 1.00 14.46 ? 348 ILE A CG2 1 ATOM 2111 C CD1 . ILE A 1 279 ? 20.694 -20.414 -35.834 1.00 13.86 ? 348 ILE A CD1 1 ATOM 2112 N N . LYS A 1 280 ? 22.500 -18.150 -39.870 1.00 15.50 ? 349 LYS A N 1 ATOM 2113 C CA . LYS A 1 280 ? 22.623 -18.639 -41.229 1.00 15.80 ? 349 LYS A CA 1 ATOM 2114 C C . LYS A 1 280 ? 21.550 -19.682 -41.507 1.00 16.16 ? 349 LYS A C 1 ATOM 2115 O O . LYS A 1 280 ? 21.285 -20.544 -40.663 1.00 16.09 ? 349 LYS A O 1 ATOM 2116 C CB . LYS A 1 280 ? 23.997 -19.279 -41.456 1.00 15.73 ? 349 LYS A CB 1 ATOM 2117 C CG . LYS A 1 280 ? 24.261 -19.701 -42.935 1.00 14.32 ? 349 LYS A CG 1 ATOM 2118 C CD . LYS A 1 280 ? 25.662 -20.301 -43.108 1.00 12.84 ? 349 LYS A CD 1 ATOM 2119 C CE . LYS A 1 280 ? 25.822 -20.961 -44.456 1.00 13.67 ? 349 LYS A CE 1 ATOM 2120 N NZ . LYS A 1 280 ? 25.734 -20.003 -45.591 1.00 11.43 ? 349 LYS A NZ 1 ATOM 2121 N N . GLY A 1 281 ? 20.956 -19.614 -42.700 1.00 16.27 ? 350 GLY A N 1 ATOM 2122 C CA . GLY A 1 281 ? 19.805 -20.449 -43.026 1.00 16.24 ? 350 GLY A CA 1 ATOM 2123 C C . GLY A 1 281 ? 19.996 -21.261 -44.280 1.00 16.37 ? 350 GLY A C 1 ATOM 2124 O O . GLY A 1 281 ? 20.632 -20.793 -45.238 1.00 16.78 ? 350 GLY A O 1 ATOM 2125 N N . GLY A 1 282 ? 19.461 -22.489 -44.244 1.00 15.87 ? 351 GLY A N 1 ATOM 2126 C CA . GLY A 1 282 ? 19.453 -23.389 -45.361 1.00 15.15 ? 351 GLY A CA 1 ATOM 2127 C C . GLY A 1 282 ? 18.592 -22.878 -46.500 1.00 15.16 ? 351 GLY A C 1 ATOM 2128 O O . GLY A 1 282 ? 17.575 -22.234 -46.273 1.00 13.78 ? 351 GLY A O 1 ATOM 2129 N N . PHE A 1 283 ? 19.024 -23.157 -47.730 1.00 15.28 ? 352 PHE A N 1 ATOM 2130 C CA . PHE A 1 283 ? 18.309 -22.712 -48.919 1.00 16.30 ? 352 PHE A CA 1 ATOM 2131 C C . PHE A 1 283 ? 18.825 -23.473 -50.133 1.00 16.51 ? 352 PHE A C 1 ATOM 2132 O O . PHE A 1 283 ? 20.014 -23.551 -50.366 1.00 16.23 ? 352 PHE A O 1 ATOM 2133 C CB . PHE A 1 283 ? 18.464 -21.205 -49.130 1.00 16.15 ? 352 PHE A CB 1 ATOM 2134 C CG . PHE A 1 283 ? 17.936 -20.716 -50.457 1.00 19.20 ? 352 PHE A CG 1 ATOM 2135 C CD1 . PHE A 1 283 ? 16.643 -21.020 -50.865 1.00 20.32 ? 352 PHE A CD1 1 ATOM 2136 C CD2 . PHE A 1 283 ? 18.719 -19.928 -51.293 1.00 19.81 ? 352 PHE A CD2 1 ATOM 2137 C CE1 . PHE A 1 283 ? 16.148 -20.567 -52.079 1.00 19.85 ? 352 PHE A CE1 1 ATOM 2138 C CE2 . PHE A 1 283 ? 18.213 -19.473 -52.519 1.00 21.27 ? 352 PHE A CE2 1 ATOM 2139 C CZ . PHE A 1 283 ? 16.929 -19.788 -52.897 1.00 20.74 ? 352 PHE A CZ 1 ATOM 2140 N N . VAL A 1 284 ? 17.922 -24.046 -50.902 1.00 17.02 ? 353 VAL A N 1 ATOM 2141 C CA . VAL A 1 284 ? 18.323 -24.847 -52.027 1.00 16.81 ? 353 VAL A CA 1 ATOM 2142 C C . VAL A 1 284 ? 17.224 -24.901 -53.063 1.00 16.39 ? 353 VAL A C 1 ATOM 2143 O O . VAL A 1 284 ? 16.047 -24.805 -52.747 1.00 15.66 ? 353 VAL A O 1 ATOM 2144 C CB . VAL A 1 284 ? 18.810 -26.269 -51.579 1.00 17.06 ? 353 VAL A CB 1 ATOM 2145 C CG1 . VAL A 1 284 ? 17.640 -27.227 -51.309 1.00 16.82 ? 353 VAL A CG1 1 ATOM 2146 C CG2 . VAL A 1 284 ? 19.768 -26.851 -52.627 1.00 17.56 ? 353 VAL A CG2 1 ATOM 2147 N N . HIS A 1 285 ? 17.649 -25.066 -54.314 1.00 17.39 ? 354 HIS A N 1 ATOM 2148 C CA . HIS A 1 285 ? 16.791 -24.977 -55.486 1.00 17.20 ? 354 HIS A CA 1 ATOM 2149 C C . HIS A 1 285 ? 16.433 -26.353 -56.030 1.00 17.91 ? 354 HIS A C 1 ATOM 2150 O O . HIS A 1 285 ? 17.290 -27.235 -56.100 1.00 18.69 ? 354 HIS A O 1 ATOM 2151 C CB . HIS A 1 285 ? 17.514 -24.194 -56.575 1.00 17.44 ? 354 HIS A CB 1 ATOM 2152 C CG . HIS A 1 285 ? 17.621 -22.728 -56.295 1.00 17.34 ? 354 HIS A CG 1 ATOM 2153 N ND1 . HIS A 1 285 ? 18.777 -22.141 -55.832 1.00 17.67 ? 354 HIS A ND1 1 ATOM 2154 C CD2 . HIS A 1 285 ? 16.717 -21.728 -56.432 1.00 17.00 ? 354 HIS A CD2 1 ATOM 2155 C CE1 . HIS A 1 285 ? 18.574 -20.843 -55.673 1.00 18.72 ? 354 HIS A CE1 1 ATOM 2156 N NE2 . HIS A 1 285 ? 17.331 -20.569 -56.029 1.00 17.98 ? 354 HIS A NE2 1 ATOM 2157 N N . GLN A 1 286 ? 15.173 -26.518 -56.429 1.00 18.30 ? 355 GLN A N 1 ATOM 2158 C CA . GLN A 1 286 ? 14.704 -27.674 -57.167 1.00 18.62 ? 355 GLN A CA 1 ATOM 2159 C C . GLN A 1 286 ? 14.323 -27.206 -58.580 1.00 18.90 ? 355 GLN A C 1 ATOM 2160 O O . GLN A 1 286 ? 13.253 -26.677 -58.785 1.00 18.73 ? 355 GLN A O 1 ATOM 2161 C CB . GLN A 1 286 ? 13.488 -28.235 -56.456 1.00 19.01 ? 355 GLN A CB 1 ATOM 2162 C CG . GLN A 1 286 ? 13.121 -29.649 -56.902 1.00 20.39 ? 355 GLN A CG 1 ATOM 2163 C CD . GLN A 1 286 ? 11.779 -30.086 -56.386 1.00 19.69 ? 355 GLN A CD 1 ATOM 2164 O OE1 . GLN A 1 286 ? 11.224 -29.472 -55.472 1.00 21.50 ? 355 GLN A OE1 1 ATOM 2165 N NE2 . GLN A 1 286 ? 11.256 -31.173 -56.948 1.00 20.65 ? 355 GLN A NE2 1 ATOM 2166 N N . ARG A 1 287 ? 15.210 -27.370 -59.552 1.00 19.75 ? 356 ARG A N 1 ATOM 2167 C CA . ARG A 1 287 ? 14.987 -26.809 -60.897 1.00 20.13 ? 356 ARG A CA 1 ATOM 2168 C C . ARG A 1 287 ? 14.276 -27.798 -61.803 1.00 21.49 ? 356 ARG A C 1 ATOM 2169 O O . ARG A 1 287 ? 14.822 -28.858 -62.080 1.00 21.51 ? 356 ARG A O 1 ATOM 2170 C CB . ARG A 1 287 ? 16.329 -26.421 -61.521 1.00 20.26 ? 356 ARG A CB 1 ATOM 2171 C CG . ARG A 1 287 ? 17.042 -25.257 -60.792 1.00 17.27 ? 356 ARG A CG 1 ATOM 2172 C CD . ARG A 1 287 ? 18.428 -25.008 -61.247 1.00 13.29 ? 356 ARG A CD 1 ATOM 2173 N NE . ARG A 1 287 ? 19.253 -26.206 -61.258 1.00 12.36 ? 356 ARG A NE 1 ATOM 2174 C CZ . ARG A 1 287 ? 20.059 -26.608 -60.273 1.00 16.03 ? 356 ARG A CZ 1 ATOM 2175 N NH1 . ARG A 1 287 ? 20.174 -25.904 -59.138 1.00 15.01 ? 356 ARG A NH1 1 ATOM 2176 N NH2 . ARG A 1 287 ? 20.748 -27.741 -60.421 1.00 16.53 ? 356 ARG A NH2 1 ATOM 2177 N N . MET A 1 288 ? 13.056 -27.470 -62.239 1.00 23.26 ? 357 MET A N 1 ATOM 2178 C CA . MET A 1 288 ? 12.276 -28.332 -63.160 1.00 24.88 ? 357 MET A CA 1 ATOM 2179 C C . MET A 1 288 ? 12.112 -27.680 -64.535 1.00 26.40 ? 357 MET A C 1 ATOM 2180 O O . MET A 1 288 ? 12.441 -26.504 -64.717 1.00 25.96 ? 357 MET A O 1 ATOM 2181 C CB . MET A 1 288 ? 10.897 -28.668 -62.578 1.00 25.10 ? 357 MET A CB 1 ATOM 2182 C CG . MET A 1 288 ? 10.951 -29.578 -61.317 1.00 27.06 ? 357 MET A CG 1 ATOM 2183 S SD . MET A 1 288 ? 9.583 -29.291 -60.168 1.00 30.86 ? 357 MET A SD 1 ATOM 2184 C CE . MET A 1 288 ? 10.023 -27.632 -59.615 1.00 30.09 ? 357 MET A CE 1 ATOM 2185 N N . ALA A 1 289 ? 11.594 -28.448 -65.497 1.00 28.10 ? 358 ALA A N 1 ATOM 2186 C CA . ALA A 1 289 ? 11.492 -27.986 -66.902 1.00 29.60 ? 358 ALA A CA 1 ATOM 2187 C C . ALA A 1 289 ? 10.685 -26.694 -67.052 1.00 30.57 ? 358 ALA A C 1 ATOM 2188 O O . ALA A 1 289 ? 11.091 -25.796 -67.783 1.00 32.10 ? 358 ALA A O 1 ATOM 2189 C CB . ALA A 1 289 ? 10.909 -29.101 -67.808 1.00 29.46 ? 358 ALA A CB 1 ATOM 2190 N N . SER A 1 290 ? 9.563 -26.580 -66.349 1.00 31.47 ? 359 SER A N 1 ATOM 2191 C CA . SER A 1 290 ? 8.758 -25.346 -66.409 1.00 31.45 ? 359 SER A CA 1 ATOM 2192 C C . SER A 1 290 ? 8.304 -24.824 -65.035 1.00 30.62 ? 359 SER A C 1 ATOM 2193 O O . SER A 1 290 ? 7.220 -24.270 -64.913 1.00 30.45 ? 359 SER A O 1 ATOM 2194 C CB . SER A 1 290 ? 7.546 -25.569 -67.333 1.00 31.82 ? 359 SER A CB 1 ATOM 2195 O OG . SER A 1 290 ? 7.794 -25.019 -68.616 1.00 33.17 ? 359 SER A OG 1 ATOM 2196 N N . LYS A 1 291 ? 9.156 -24.970 -64.020 1.00 29.79 ? 360 LYS A N 1 ATOM 2197 C CA . LYS A 1 291 ? 8.796 -24.652 -62.630 1.00 28.74 ? 360 LYS A CA 1 ATOM 2198 C C . LYS A 1 291 ? 10.028 -24.695 -61.715 1.00 27.41 ? 360 LYS A C 1 ATOM 2199 O O . LYS A 1 291 ? 10.945 -25.476 -61.941 1.00 27.36 ? 360 LYS A O 1 ATOM 2200 C CB . LYS A 1 291 ? 7.770 -25.669 -62.145 1.00 28.93 ? 360 LYS A CB 1 ATOM 2201 C CG . LYS A 1 291 ? 7.238 -25.432 -60.748 1.00 30.04 ? 360 LYS A CG 1 ATOM 2202 C CD . LYS A 1 291 ? 6.296 -26.541 -60.335 1.00 32.03 ? 360 LYS A CD 1 ATOM 2203 C CE . LYS A 1 291 ? 4.915 -26.405 -60.973 1.00 32.70 ? 360 LYS A CE 1 ATOM 2204 N NZ . LYS A 1 291 ? 4.132 -27.649 -60.772 1.00 33.99 ? 360 LYS A NZ 1 ATOM 2205 N N . ILE A 1 292 ? 10.045 -23.877 -60.673 1.00 25.57 ? 361 ILE A N 1 ATOM 2206 C CA . ILE A 1 292 ? 11.172 -23.882 -59.740 1.00 24.62 ? 361 ILE A CA 1 ATOM 2207 C C . ILE A 1 292 ? 10.729 -23.980 -58.257 1.00 23.20 ? 361 ILE A C 1 ATOM 2208 O O . ILE A 1 292 ? 9.867 -23.253 -57.793 1.00 22.65 ? 361 ILE A O 1 ATOM 2209 C CB . ILE A 1 292 ? 12.113 -22.667 -60.009 1.00 24.66 ? 361 ILE A CB 1 ATOM 2210 C CG1 . ILE A 1 292 ? 13.531 -22.974 -59.506 1.00 25.19 ? 361 ILE A CG1 1 ATOM 2211 C CG2 . ILE A 1 292 ? 11.532 -21.370 -59.447 1.00 23.88 ? 361 ILE A CG2 1 ATOM 2212 C CD1 . ILE A 1 292 ? 14.399 -21.770 -59.356 1.00 26.33 ? 361 ILE A CD1 1 ATOM 2213 N N . GLY A 1 293 ? 11.301 -24.933 -57.540 1.00 21.88 ? 362 GLY A N 1 ATOM 2214 C CA . GLY A 1 293 ? 11.031 -25.099 -56.100 1.00 21.21 ? 362 GLY A CA 1 ATOM 2215 C C . GLY A 1 293 ? 12.140 -24.409 -55.309 1.00 20.42 ? 362 GLY A C 1 ATOM 2216 O O . GLY A 1 293 ? 13.319 -24.539 -55.637 1.00 20.17 ? 362 GLY A O 1 ATOM 2217 N N . ARG A 1 294 ? 11.761 -23.627 -54.315 1.00 19.74 ? 363 ARG A N 1 ATOM 2218 C CA . ARG A 1 294 ? 12.731 -23.049 -53.371 1.00 19.19 ? 363 ARG A CA 1 ATOM 2219 C C . ARG A 1 294 ? 12.543 -23.681 -52.002 1.00 18.14 ? 363 ARG A C 1 ATOM 2220 O O . ARG A 1 294 ? 11.465 -23.613 -51.448 1.00 18.02 ? 363 ARG A O 1 ATOM 2221 C CB . ARG A 1 294 ? 12.551 -21.535 -53.279 1.00 19.54 ? 363 ARG A CB 1 ATOM 2222 C CG . ARG A 1 294 ? 12.768 -20.852 -54.625 1.00 20.10 ? 363 ARG A CG 1 ATOM 2223 C CD . ARG A 1 294 ? 13.027 -19.372 -54.522 1.00 22.11 ? 363 ARG A CD 1 ATOM 2224 N NE . ARG A 1 294 ? 13.362 -18.871 -55.856 1.00 23.43 ? 363 ARG A NE 1 ATOM 2225 C CZ . ARG A 1 294 ? 12.466 -18.606 -56.810 1.00 26.65 ? 363 ARG A CZ 1 ATOM 2226 N NH1 . ARG A 1 294 ? 11.158 -18.755 -56.577 1.00 27.60 ? 363 ARG A NH1 1 ATOM 2227 N NH2 . ARG A 1 294 ? 12.879 -18.184 -58.009 1.00 26.51 ? 363 ARG A NH2 1 ATOM 2228 N N . TRP A 1 295 ? 13.599 -24.291 -51.472 1.00 17.16 ? 364 TRP A N 1 ATOM 2229 C CA . TRP A 1 295 ? 13.539 -25.014 -50.203 1.00 15.87 ? 364 TRP A CA 1 ATOM 2230 C C . TRP A 1 295 ? 14.329 -24.233 -49.125 1.00 15.58 ? 364 TRP A C 1 ATOM 2231 O O . TRP A 1 295 ? 15.430 -23.750 -49.382 1.00 15.08 ? 364 TRP A O 1 ATOM 2232 C CB . TRP A 1 295 ? 14.091 -26.438 -50.356 1.00 14.92 ? 364 TRP A CB 1 ATOM 2233 C CG . TRP A 1 295 ? 13.235 -27.375 -51.179 1.00 14.85 ? 364 TRP A CG 1 ATOM 2234 C CD1 . TRP A 1 295 ? 13.233 -27.492 -52.557 1.00 14.23 ? 364 TRP A CD1 1 ATOM 2235 C CD2 . TRP A 1 295 ? 12.262 -28.317 -50.704 1.00 13.44 ? 364 TRP A CD2 1 ATOM 2236 N NE1 . TRP A 1 295 ? 12.332 -28.434 -52.950 1.00 13.39 ? 364 TRP A NE1 1 ATOM 2237 C CE2 . TRP A 1 295 ? 11.722 -28.965 -51.846 1.00 11.26 ? 364 TRP A CE2 1 ATOM 2238 C CE3 . TRP A 1 295 ? 11.808 -28.690 -49.427 1.00 12.34 ? 364 TRP A CE3 1 ATOM 2239 C CZ2 . TRP A 1 295 ? 10.755 -29.951 -51.759 1.00 12.16 ? 364 TRP A CZ2 1 ATOM 2240 C CZ3 . TRP A 1 295 ? 10.838 -29.667 -49.328 1.00 13.61 ? 364 TRP A CZ3 1 ATOM 2241 C CH2 . TRP A 1 295 ? 10.324 -30.311 -50.495 1.00 15.63 ? 364 TRP A CH2 1 ATOM 2242 N N . TYR A 1 296 ? 13.756 -24.130 -47.936 1.00 14.86 ? 365 TYR A N 1 ATOM 2243 C CA . TYR A 1 296 ? 14.298 -23.301 -46.871 1.00 15.50 ? 365 TYR A CA 1 ATOM 2244 C C . TYR A 1 296 ? 14.202 -24.065 -45.567 1.00 15.37 ? 365 TYR A C 1 ATOM 2245 O O . TYR A 1 296 ? 13.381 -24.961 -45.449 1.00 14.18 ? 365 TYR A O 1 ATOM 2246 C CB . TYR A 1 296 ? 13.481 -21.990 -46.692 1.00 15.89 ? 365 TYR A CB 1 ATOM 2247 C CG . TYR A 1 296 ? 13.348 -21.130 -47.943 1.00 15.36 ? 365 TYR A CG 1 ATOM 2248 C CD1 . TYR A 1 296 ? 14.263 -20.134 -48.241 1.00 14.01 ? 365 TYR A CD1 1 ATOM 2249 C CD2 . TYR A 1 296 ? 12.282 -21.318 -48.812 1.00 15.50 ? 365 TYR A CD2 1 ATOM 2250 C CE1 . TYR A 1 296 ? 14.128 -19.370 -49.416 1.00 15.97 ? 365 TYR A CE1 1 ATOM 2251 C CE2 . TYR A 1 296 ? 12.133 -20.559 -49.955 1.00 15.46 ? 365 TYR A CE2 1 ATOM 2252 C CZ . TYR A 1 296 ? 13.046 -19.602 -50.257 1.00 15.20 ? 365 TYR A CZ 1 ATOM 2253 O OH . TYR A 1 296 ? 12.844 -18.886 -51.406 1.00 17.18 ? 365 TYR A OH 1 ATOM 2254 N N . SER A 1 297 ? 15.004 -23.669 -44.586 1.00 15.94 ? 366 SER A N 1 ATOM 2255 C CA A SER A 1 297 ? 14.913 -24.237 -43.244 0.50 16.37 ? 366 SER A CA 1 ATOM 2256 C CA B SER A 1 297 ? 14.903 -24.233 -43.244 0.50 16.22 ? 366 SER A CA 1 ATOM 2257 C C . SER A 1 297 ? 14.938 -23.150 -42.187 1.00 16.37 ? 366 SER A C 1 ATOM 2258 O O . SER A 1 297 ? 15.445 -22.065 -42.414 1.00 17.58 ? 366 SER A O 1 ATOM 2259 C CB A SER A 1 297 ? 16.048 -25.248 -42.997 0.50 16.68 ? 366 SER A CB 1 ATOM 2260 C CB B SER A 1 297 ? 16.009 -25.278 -42.981 0.50 16.52 ? 366 SER A CB 1 ATOM 2261 O OG A SER A 1 297 ? 17.274 -24.629 -42.639 0.50 17.76 ? 366 SER A OG 1 ATOM 2262 O OG B SER A 1 297 ? 17.317 -24.801 -43.258 0.50 16.66 ? 366 SER A OG 1 ATOM 2263 N N . ARG A 1 298 ? 14.380 -23.443 -41.032 1.00 15.86 ? 367 ARG A N 1 ATOM 2264 C CA . ARG A 1 298 ? 14.436 -22.509 -39.952 1.00 15.96 ? 367 ARG A CA 1 ATOM 2265 C C . ARG A 1 298 ? 14.184 -23.253 -38.687 1.00 16.38 ? 367 ARG A C 1 ATOM 2266 O O . ARG A 1 298 ? 13.657 -24.359 -38.687 1.00 15.48 ? 367 ARG A O 1 ATOM 2267 C CB . ARG A 1 298 ? 13.412 -21.359 -40.098 1.00 15.96 ? 367 ARG A CB 1 ATOM 2268 C CG . ARG A 1 298 ? 11.950 -21.754 -39.835 1.00 15.21 ? 367 ARG A CG 1 ATOM 2269 C CD . ARG A 1 298 ? 11.020 -20.537 -39.890 1.00 15.76 ? 367 ARG A CD 1 ATOM 2270 N NE . ARG A 1 298 ? 9.637 -20.889 -39.570 1.00 15.31 ? 367 ARG A NE 1 ATOM 2271 C CZ . ARG A 1 298 ? 8.650 -20.003 -39.417 1.00 17.91 ? 367 ARG A CZ 1 ATOM 2272 N NH1 . ARG A 1 298 ? 8.858 -18.699 -39.568 1.00 18.78 ? 367 ARG A NH1 1 ATOM 2273 N NH2 . ARG A 1 298 ? 7.438 -20.424 -39.120 1.00 19.72 ? 367 ARG A NH2 1 ATOM 2274 N N . THR A 1 299 ? 14.520 -22.569 -37.612 1.00 17.14 ? 368 THR A N 1 ATOM 2275 C CA . THR A 1 299 ? 14.587 -23.123 -36.273 1.00 18.07 ? 368 THR A CA 1 ATOM 2276 C C . THR A 1 299 ? 13.147 -23.357 -35.738 1.00 18.67 ? 368 THR A C 1 ATOM 2277 O O . THR A 1 299 ? 12.235 -22.620 -36.099 1.00 18.32 ? 368 THR A O 1 ATOM 2278 C CB . THR A 1 299 ? 15.430 -22.105 -35.466 1.00 18.33 ? 368 THR A CB 1 ATOM 2279 O OG1 . THR A 1 299 ? 16.547 -22.737 -34.830 1.00 21.41 ? 368 THR A OG1 1 ATOM 2280 C CG2 . THR A 1 299 ? 14.604 -21.276 -34.549 1.00 16.70 ? 368 THR A CG2 1 ATOM 2281 N N . MET A 1 300 ? 12.916 -24.390 -34.922 1.00 19.10 ? 369 MET A N 1 ATOM 2282 C CA . MET A 1 300 ? 11.556 -24.621 -34.391 1.00 19.59 ? 369 MET A CA 1 ATOM 2283 C C . MET A 1 300 ? 11.211 -23.523 -33.391 1.00 19.54 ? 369 MET A C 1 ATOM 2284 O O . MET A 1 300 ? 10.122 -22.972 -33.456 1.00 20.02 ? 369 MET A O 1 ATOM 2285 C CB . MET A 1 300 ? 11.354 -26.005 -33.752 1.00 19.35 ? 369 MET A CB 1 ATOM 2286 C CG . MET A 1 300 ? 11.356 -27.172 -34.737 1.00 22.28 ? 369 MET A CG 1 ATOM 2287 S SD . MET A 1 300 ? 10.344 -26.912 -36.221 1.00 26.30 ? 369 MET A SD 1 ATOM 2288 C CE . MET A 1 300 ? 8.705 -27.113 -35.502 1.00 22.95 ? 369 MET A CE 1 ATOM 2289 N N . SER A 1 301 ? 12.130 -23.191 -32.487 1.00 19.07 ? 370 SER A N 1 ATOM 2290 C CA . SER A 1 301 ? 11.871 -22.100 -31.554 1.00 18.82 ? 370 SER A CA 1 ATOM 2291 C C . SER A 1 301 ? 11.964 -20.767 -32.293 1.00 18.62 ? 370 SER A C 1 ATOM 2292 O O . SER A 1 301 ? 12.800 -20.595 -33.169 1.00 18.29 ? 370 SER A O 1 ATOM 2293 C CB . SER A 1 301 ? 12.835 -22.139 -30.359 1.00 18.53 ? 370 SER A CB 1 ATOM 2294 O OG . SER A 1 301 ? 12.745 -20.948 -29.601 1.00 17.17 ? 370 SER A OG 1 ATOM 2295 N N . LYS A 1 302 ? 11.098 -19.820 -31.936 1.00 18.40 ? 371 LYS A N 1 ATOM 2296 C CA . LYS A 1 302 ? 11.170 -18.470 -32.505 1.00 18.22 ? 371 LYS A CA 1 ATOM 2297 C C . LYS A 1 302 ? 12.362 -17.634 -31.992 1.00 17.76 ? 371 LYS A C 1 ATOM 2298 O O . LYS A 1 302 ? 12.761 -16.675 -32.637 1.00 16.95 ? 371 LYS A O 1 ATOM 2299 C CB . LYS A 1 302 ? 9.856 -17.742 -32.235 1.00 19.04 ? 371 LYS A CB 1 ATOM 2300 C CG . LYS A 1 302 ? 8.661 -18.314 -33.040 1.00 20.39 ? 371 LYS A CG 1 ATOM 2301 C CD . LYS A 1 302 ? 7.288 -17.739 -32.620 1.00 20.47 ? 371 LYS A CD 1 ATOM 2302 C CE . LYS A 1 302 ? 6.781 -18.370 -31.326 1.00 20.62 ? 371 LYS A CE 1 ATOM 2303 N NZ . LYS A 1 302 ? 5.339 -18.083 -30.976 1.00 17.96 ? 371 LYS A NZ 1 ATOM 2304 N N . THR A 1 303 ? 12.929 -18.017 -30.841 1.00 17.44 ? 372 THR A N 1 ATOM 2305 C CA . THR A 1 303 ? 13.943 -17.232 -30.137 1.00 17.21 ? 372 THR A CA 1 ATOM 2306 C C . THR A 1 303 ? 15.287 -17.943 -29.934 1.00 17.32 ? 372 THR A C 1 ATOM 2307 O O . THR A 1 303 ? 16.345 -17.301 -30.034 1.00 17.31 ? 372 THR A O 1 ATOM 2308 C CB . THR A 1 303 ? 13.457 -16.830 -28.744 1.00 17.29 ? 372 THR A CB 1 ATOM 2309 O OG1 . THR A 1 303 ? 12.147 -16.243 -28.831 1.00 17.18 ? 372 THR A OG1 1 ATOM 2310 C CG2 . THR A 1 303 ? 14.429 -15.823 -28.121 1.00 17.19 ? 372 THR A CG2 1 ATOM 2311 N N . LYS A 1 304 ? 15.233 -19.238 -29.604 1.00 17.18 ? 373 LYS A N 1 ATOM 2312 C CA . LYS A 1 304 ? 16.414 -20.053 -29.328 1.00 16.78 ? 373 LYS A CA 1 ATOM 2313 C C . LYS A 1 304 ? 16.771 -20.917 -30.533 1.00 16.58 ? 373 LYS A C 1 ATOM 2314 O O . LYS A 1 304 ? 15.954 -21.112 -31.453 1.00 15.03 ? 373 LYS A O 1 ATOM 2315 C CB . LYS A 1 304 ? 16.154 -20.948 -28.102 1.00 17.32 ? 373 LYS A CB 1 ATOM 2316 C CG . LYS A 1 304 ? 15.749 -20.185 -26.823 1.00 19.10 ? 373 LYS A CG 1 ATOM 2317 C CD . LYS A 1 304 ? 15.767 -21.087 -25.585 1.00 23.14 ? 373 LYS A CD 1 ATOM 2318 C CE . LYS A 1 304 ? 14.707 -20.703 -24.562 1.00 25.88 ? 373 LYS A CE 1 ATOM 2319 N NZ . LYS A 1 304 ? 13.324 -20.606 -25.197 1.00 28.27 ? 373 LYS A NZ 1 ATOM 2320 N N . ARG A 1 305 ? 18.000 -21.436 -30.509 1.00 17.08 ? 374 ARG A N 1 ATOM 2321 C CA . ARG A 1 305 ? 18.557 -22.260 -31.589 1.00 16.71 ? 374 ARG A CA 1 ATOM 2322 C C . ARG A 1 305 ? 18.279 -23.732 -31.272 1.00 17.22 ? 374 ARG A C 1 ATOM 2323 O O . ARG A 1 305 ? 19.186 -24.532 -30.992 1.00 16.85 ? 374 ARG A O 1 ATOM 2324 C CB . ARG A 1 305 ? 20.051 -21.979 -31.756 1.00 17.13 ? 374 ARG A CB 1 ATOM 2325 C CG . ARG A 1 305 ? 20.344 -20.530 -32.213 1.00 15.66 ? 374 ARG A CG 1 ATOM 2326 C CD . ARG A 1 305 ? 21.786 -20.199 -32.304 1.00 13.66 ? 374 ARG A CD 1 ATOM 2327 N NE . ARG A 1 305 ? 21.992 -18.966 -33.063 1.00 16.36 ? 374 ARG A NE 1 ATOM 2328 C CZ . ARG A 1 305 ? 23.174 -18.531 -33.510 1.00 15.36 ? 374 ARG A CZ 1 ATOM 2329 N NH1 . ARG A 1 305 ? 24.289 -19.203 -33.266 1.00 15.15 ? 374 ARG A NH1 1 ATOM 2330 N NH2 . ARG A 1 305 ? 23.249 -17.425 -34.229 1.00 15.49 ? 374 ARG A NH2 1 ATOM 2331 N N . MET A 1 306 ? 16.983 -24.052 -31.314 1.00 17.34 ? 375 MET A N 1 ATOM 2332 C CA . MET A 1 306 ? 16.445 -25.343 -30.939 1.00 17.48 ? 375 MET A CA 1 ATOM 2333 C C . MET A 1 306 ? 15.511 -25.772 -32.052 1.00 17.23 ? 375 MET A C 1 ATOM 2334 O O . MET A 1 306 ? 14.680 -24.989 -32.509 1.00 18.13 ? 375 MET A O 1 ATOM 2335 C CB . MET A 1 306 ? 15.651 -25.234 -29.631 1.00 17.98 ? 375 MET A CB 1 ATOM 2336 C CG . MET A 1 306 ? 16.446 -24.749 -28.402 1.00 19.91 ? 375 MET A CG 1 ATOM 2337 S SD . MET A 1 306 ? 17.946 -25.696 -28.037 1.00 26.13 ? 375 MET A SD 1 ATOM 2338 C CE . MET A 1 306 ? 17.249 -27.324 -27.691 1.00 25.49 ? 375 MET A CE 1 ATOM 2339 N N . GLY A 1 307 ? 15.644 -27.009 -32.490 1.00 16.23 ? 376 GLY A N 1 ATOM 2340 C CA . GLY A 1 307 ? 14.854 -27.517 -33.593 1.00 16.07 ? 376 GLY A CA 1 ATOM 2341 C C . GLY A 1 307 ? 15.235 -26.957 -34.966 1.00 15.02 ? 376 GLY A C 1 ATOM 2342 O O . GLY A 1 307 ? 16.010 -26.019 -35.066 1.00 14.15 ? 376 GLY A O 1 ATOM 2343 N N . MET A 1 308 ? 14.667 -27.553 -36.007 1.00 14.73 ? 377 MET A N 1 ATOM 2344 C CA . MET A 1 308 ? 14.817 -27.068 -37.401 1.00 15.41 ? 377 MET A CA 1 ATOM 2345 C C . MET A 1 308 ? 13.715 -27.620 -38.315 1.00 15.09 ? 377 MET A C 1 ATOM 2346 O O . MET A 1 308 ? 13.657 -28.815 -38.539 1.00 16.36 ? 377 MET A O 1 ATOM 2347 C CB . MET A 1 308 ? 16.173 -27.460 -37.945 1.00 15.35 ? 377 MET A CB 1 ATOM 2348 C CG . MET A 1 308 ? 16.565 -26.786 -39.239 1.00 16.85 ? 377 MET A CG 1 ATOM 2349 S SD . MET A 1 308 ? 16.939 -25.051 -39.045 1.00 17.46 ? 377 MET A SD 1 ATOM 2350 C CE . MET A 1 308 ? 18.387 -25.058 -37.969 1.00 17.78 ? 377 MET A CE 1 ATOM 2351 N N . GLY A 1 309 ? 12.829 -26.770 -38.825 1.00 15.15 ? 378 GLY A N 1 ATOM 2352 C CA . GLY A 1 309 ? 11.789 -27.212 -39.786 1.00 15.90 ? 378 GLY A CA 1 ATOM 2353 C C . GLY A 1 309 ? 12.207 -26.978 -41.242 1.00 16.18 ? 378 GLY A C 1 ATOM 2354 O O . GLY A 1 309 ? 13.033 -26.111 -41.511 1.00 16.24 ? 378 GLY A O 1 ATOM 2355 N N . LEU A 1 310 ? 11.656 -27.759 -42.174 1.00 16.65 ? 379 LEU A N 1 ATOM 2356 C CA . LEU A 1 310 ? 11.890 -27.557 -43.622 1.00 17.23 ? 379 LEU A CA 1 ATOM 2357 C C . LEU A 1 310 ? 10.646 -27.013 -44.294 1.00 17.96 ? 379 LEU A C 1 ATOM 2358 O O . LEU A 1 310 ? 9.555 -27.557 -44.106 1.00 17.82 ? 379 LEU A O 1 ATOM 2359 C CB . LEU A 1 310 ? 12.238 -28.879 -44.315 1.00 17.17 ? 379 LEU A CB 1 ATOM 2360 C CG . LEU A 1 310 ? 12.612 -28.821 -45.804 1.00 15.79 ? 379 LEU A CG 1 ATOM 2361 C CD1 . LEU A 1 310 ? 13.970 -28.200 -45.964 1.00 12.95 ? 379 LEU A CD1 1 ATOM 2362 C CD2 . LEU A 1 310 ? 12.617 -30.200 -46.413 1.00 14.70 ? 379 LEU A CD2 1 ATOM 2363 N N . TYR A 1 311 ? 10.807 -25.967 -45.100 1.00 18.77 ? 380 TYR A N 1 ATOM 2364 C CA . TYR A 1 311 ? 9.681 -25.369 -45.820 1.00 19.43 ? 380 TYR A CA 1 ATOM 2365 C C . TYR A 1 311 ? 9.977 -25.314 -47.324 1.00 19.94 ? 380 TYR A C 1 ATOM 2366 O O . TYR A 1 311 ? 11.138 -25.416 -47.740 1.00 20.33 ? 380 TYR A O 1 ATOM 2367 C CB . TYR A 1 311 ? 9.375 -23.975 -45.253 1.00 19.48 ? 380 TYR A CB 1 ATOM 2368 C CG . TYR A 1 311 ? 9.033 -23.952 -43.770 1.00 19.96 ? 380 TYR A CG 1 ATOM 2369 C CD1 . TYR A 1 311 ? 7.763 -23.608 -43.333 1.00 19.96 ? 380 TYR A CD1 1 ATOM 2370 C CD2 . TYR A 1 311 ? 10.002 -24.242 -42.791 1.00 20.54 ? 380 TYR A CD2 1 ATOM 2371 C CE1 . TYR A 1 311 ? 7.458 -23.555 -41.949 1.00 20.76 ? 380 TYR A CE1 1 ATOM 2372 C CE2 . TYR A 1 311 ? 9.705 -24.199 -41.421 1.00 19.77 ? 380 TYR A CE2 1 ATOM 2373 C CZ . TYR A 1 311 ? 8.430 -23.863 -41.009 1.00 20.97 ? 380 TYR A CZ 1 ATOM 2374 O OH . TYR A 1 311 ? 8.124 -23.836 -39.662 1.00 21.79 ? 380 TYR A OH 1 ATOM 2375 N N . VAL A 1 312 ? 8.931 -25.173 -48.138 1.00 20.94 ? 381 VAL A N 1 ATOM 2376 C CA . VAL A 1 312 ? 9.077 -25.042 -49.609 1.00 20.58 ? 381 VAL A CA 1 ATOM 2377 C C . VAL A 1 312 ? 8.010 -24.135 -50.222 1.00 21.07 ? 381 VAL A C 1 ATOM 2378 O O . VAL A 1 312 ? 6.903 -24.074 -49.730 1.00 20.53 ? 381 VAL A O 1 ATOM 2379 C CB . VAL A 1 312 ? 9.027 -26.417 -50.339 1.00 20.72 ? 381 VAL A CB 1 ATOM 2380 C CG1 . VAL A 1 312 ? 7.631 -27.052 -50.277 1.00 19.71 ? 381 VAL A CG1 1 ATOM 2381 C CG2 . VAL A 1 312 ? 9.472 -26.273 -51.807 1.00 20.92 ? 381 VAL A CG2 1 ATOM 2382 N N . LYS A 1 313 ? 8.374 -23.419 -51.292 1.00 21.73 ? 382 LYS A N 1 ATOM 2383 C CA . LYS A 1 313 ? 7.409 -22.803 -52.186 1.00 21.82 ? 382 LYS A CA 1 ATOM 2384 C C . LYS A 1 313 ? 7.879 -22.943 -53.624 1.00 22.48 ? 382 LYS A C 1 ATOM 2385 O O . LYS A 1 313 ? 9.080 -22.855 -53.927 1.00 22.64 ? 382 LYS A O 1 ATOM 2386 C CB . LYS A 1 313 ? 7.203 -21.333 -51.859 1.00 22.09 ? 382 LYS A CB 1 ATOM 2387 C CG . LYS A 1 313 ? 5.921 -20.764 -52.457 0.50 21.72 ? 382 LYS A CG 1 ATOM 2388 C CD . LYS A 1 313 ? 5.201 -19.851 -51.479 0.50 21.69 ? 382 LYS A CD 1 ATOM 2389 C CE . LYS A 1 313 ? 3.771 -19.590 -51.910 0.50 20.39 ? 382 LYS A CE 1 ATOM 2390 N NZ . LYS A 1 313 ? 3.735 -18.886 -53.213 0.50 19.98 ? 382 LYS A NZ 1 ATOM 2391 N N . TYR A 1 314 ? 6.927 -23.163 -54.516 1.00 22.92 ? 383 TYR A N 1 ATOM 2392 C CA . TYR A 1 314 ? 7.225 -23.314 -55.936 1.00 23.54 ? 383 TYR A CA 1 ATOM 2393 C C . TYR A 1 314 ? 6.860 -22.035 -56.700 1.00 23.31 ? 383 TYR A C 1 ATOM 2394 O O . TYR A 1 314 ? 5.778 -21.488 -56.522 1.00 23.24 ? 383 TYR A O 1 ATOM 2395 C CB . TYR A 1 314 ? 6.479 -24.531 -56.485 1.00 23.91 ? 383 TYR A CB 1 ATOM 2396 C CG . TYR A 1 314 ? 7.007 -25.850 -55.960 1.00 25.03 ? 383 TYR A CG 1 ATOM 2397 C CD1 . TYR A 1 314 ? 7.961 -26.554 -56.675 1.00 26.02 ? 383 TYR A CD1 1 ATOM 2398 C CD2 . TYR A 1 314 ? 6.551 -26.391 -54.747 1.00 26.67 ? 383 TYR A CD2 1 ATOM 2399 C CE1 . TYR A 1 314 ? 8.458 -27.753 -56.228 1.00 27.19 ? 383 TYR A CE1 1 ATOM 2400 C CE2 . TYR A 1 314 ? 7.048 -27.612 -54.274 1.00 26.79 ? 383 TYR A CE2 1 ATOM 2401 C CZ . TYR A 1 314 ? 8.001 -28.290 -55.030 1.00 28.02 ? 383 TYR A CZ 1 ATOM 2402 O OH . TYR A 1 314 ? 8.525 -29.499 -54.622 1.00 27.55 ? 383 TYR A OH 1 ATOM 2403 N N . ASP A 1 315 ? 7.785 -21.537 -57.510 1.00 23.73 ? 384 ASP A N 1 ATOM 2404 C CA . ASP A 1 315 ? 7.593 -20.299 -58.286 1.00 24.01 ? 384 ASP A CA 1 ATOM 2405 C C . ASP A 1 315 ? 7.238 -19.028 -57.485 1.00 24.28 ? 384 ASP A C 1 ATOM 2406 O O . ASP A 1 315 ? 7.432 -18.973 -56.264 1.00 25.14 ? 384 ASP A O 1 ATOM 2407 C CB . ASP A 1 315 ? 6.543 -20.547 -59.370 1.00 24.79 ? 384 ASP A CB 1 ATOM 2408 C CG . ASP A 1 315 ? 6.911 -21.682 -60.268 1.00 24.84 ? 384 ASP A CG 1 ATOM 2409 O OD1 . ASP A 1 315 ? 6.039 -22.526 -60.484 1.00 30.05 ? 384 ASP A OD1 1 ATOM 2410 O OD2 . ASP A 1 315 ? 8.059 -21.737 -60.745 1.00 25.99 ? 384 ASP A OD2 1 ATOM 2411 N N . GLY A 1 316 ? 6.737 -18.003 -58.186 1.00 23.89 ? 385 GLY A N 1 ATOM 2412 C CA . GLY A 1 316 ? 6.498 -16.684 -57.614 1.00 23.68 ? 385 GLY A CA 1 ATOM 2413 C C . GLY A 1 316 ? 7.781 -15.876 -57.510 1.00 23.54 ? 385 GLY A C 1 ATOM 2414 O O . GLY A 1 316 ? 8.864 -16.361 -57.843 1.00 24.59 ? 385 GLY A O 1 ATOM 2415 N N . ASP A 1 317 ? 7.667 -14.641 -57.041 1.00 23.24 ? 386 ASP A N 1 ATOM 2416 C CA . ASP A 1 317 ? 8.829 -13.808 -56.730 1.00 22.79 ? 386 ASP A CA 1 ATOM 2417 C C . ASP A 1 317 ? 8.965 -13.625 -55.191 1.00 22.51 ? 386 ASP A C 1 ATOM 2418 O O . ASP A 1 317 ? 8.117 -12.982 -54.575 1.00 21.84 ? 386 ASP A O 1 ATOM 2419 C CB . ASP A 1 317 ? 8.665 -12.466 -57.441 1.00 23.03 ? 386 ASP A CB 1 ATOM 2420 C CG . ASP A 1 317 ? 9.820 -11.532 -57.199 1.00 23.88 ? 386 ASP A CG 1 ATOM 2421 O OD1 . ASP A 1 317 ? 10.759 -11.913 -56.471 1.00 22.27 ? 386 ASP A OD1 1 ATOM 2422 O OD2 . ASP A 1 317 ? 9.768 -10.398 -57.718 1.00 26.04 ? 386 ASP A OD2 1 ATOM 2423 N N . PRO A 1 318 ? 10.037 -14.187 -54.567 1.00 22.35 ? 387 PRO A N 1 ATOM 2424 C CA . PRO A 1 318 ? 10.184 -14.089 -53.085 1.00 21.88 ? 387 PRO A CA 1 ATOM 2425 C C . PRO A 1 318 ? 10.241 -12.652 -52.554 1.00 21.74 ? 387 PRO A C 1 ATOM 2426 O O . PRO A 1 318 ? 10.000 -12.420 -51.357 1.00 20.54 ? 387 PRO A O 1 ATOM 2427 C CB . PRO A 1 318 ? 11.515 -14.811 -52.803 1.00 21.41 ? 387 PRO A CB 1 ATOM 2428 C CG . PRO A 1 318 ? 11.709 -15.726 -53.966 1.00 22.29 ? 387 PRO A CG 1 ATOM 2429 C CD . PRO A 1 318 ? 11.120 -14.998 -55.162 1.00 21.96 ? 387 PRO A CD 1 ATOM 2430 N N . TRP A 1 319 ? 10.573 -11.710 -53.440 1.00 21.75 ? 388 TRP A N 1 ATOM 2431 C CA . TRP A 1 319 ? 10.657 -10.291 -53.082 1.00 22.13 ? 388 TRP A CA 1 ATOM 2432 C C . TRP A 1 319 ? 9.293 -9.655 -52.806 1.00 22.41 ? 388 TRP A C 1 ATOM 2433 O O . TRP A 1 319 ? 9.205 -8.679 -52.092 1.00 22.62 ? 388 TRP A O 1 ATOM 2434 C CB . TRP A 1 319 ? 11.343 -9.490 -54.204 1.00 22.14 ? 388 TRP A CB 1 ATOM 2435 C CG . TRP A 1 319 ? 12.836 -9.652 -54.298 1.00 22.48 ? 388 TRP A CG 1 ATOM 2436 C CD1 . TRP A 1 319 ? 13.648 -10.268 -53.398 1.00 23.20 ? 388 TRP A CD1 1 ATOM 2437 C CD2 . TRP A 1 319 ? 13.693 -9.127 -55.320 1.00 21.87 ? 388 TRP A CD2 1 ATOM 2438 N NE1 . TRP A 1 319 ? 14.962 -10.179 -53.801 1.00 23.88 ? 388 TRP A NE1 1 ATOM 2439 C CE2 . TRP A 1 319 ? 15.019 -9.478 -54.975 1.00 22.70 ? 388 TRP A CE2 1 ATOM 2440 C CE3 . TRP A 1 319 ? 13.472 -8.404 -56.501 1.00 22.81 ? 388 TRP A CE3 1 ATOM 2441 C CZ2 . TRP A 1 319 ? 16.122 -9.142 -55.774 1.00 21.62 ? 388 TRP A CZ2 1 ATOM 2442 C CZ3 . TRP A 1 319 ? 14.566 -8.062 -57.296 1.00 21.96 ? 388 TRP A CZ3 1 ATOM 2443 C CH2 . TRP A 1 319 ? 15.877 -8.433 -56.926 1.00 22.65 ? 388 TRP A CH2 1 ATOM 2444 N N . THR A 1 320 ? 8.249 -10.180 -53.433 1.00 23.43 ? 389 THR A N 1 ATOM 2445 C CA . THR A 1 320 ? 6.946 -9.553 -53.448 1.00 23.49 ? 389 THR A CA 1 ATOM 2446 C C . THR A 1 320 ? 5.833 -10.507 -53.012 1.00 24.07 ? 389 THR A C 1 ATOM 2447 O O . THR A 1 320 ? 4.720 -10.063 -52.817 1.00 25.76 ? 389 THR A O 1 ATOM 2448 C CB . THR A 1 320 ? 6.608 -9.041 -54.895 1.00 23.88 ? 389 THR A CB 1 ATOM 2449 O OG1 . THR A 1 320 ? 6.494 -10.158 -55.783 1.00 24.18 ? 389 THR A OG1 1 ATOM 2450 C CG2 . THR A 1 320 ? 7.674 -8.071 -55.420 1.00 23.01 ? 389 THR A CG2 1 ATOM 2451 N N . ASP A 1 321 ? 6.101 -11.806 -52.888 1.00 24.07 ? 390 ASP A N 1 ATOM 2452 C CA A ASP A 1 321 ? 5.059 -12.792 -52.544 0.70 24.38 ? 390 ASP A CA 1 ATOM 2453 C CA B ASP A 1 321 ? 5.056 -12.778 -52.542 0.30 24.24 ? 390 ASP A CA 1 ATOM 2454 C C . ASP A 1 321 ? 5.007 -12.991 -51.030 1.00 24.26 ? 390 ASP A C 1 ATOM 2455 O O . ASP A 1 321 ? 5.902 -13.588 -50.443 1.00 24.38 ? 390 ASP A O 1 ATOM 2456 C CB A ASP A 1 321 ? 5.334 -14.118 -53.287 0.70 24.26 ? 390 ASP A CB 1 ATOM 2457 C CB B ASP A 1 321 ? 5.277 -14.107 -53.279 0.30 24.12 ? 390 ASP A CB 1 ATOM 2458 C CG A ASP A 1 321 ? 4.408 -15.261 -52.863 0.70 24.73 ? 390 ASP A CG 1 ATOM 2459 C CG B ASP A 1 321 ? 4.835 -14.051 -54.739 0.30 24.12 ? 390 ASP A CG 1 ATOM 2460 O OD1 A ASP A 1 321 ? 3.442 -15.052 -52.107 0.70 23.75 ? 390 ASP A OD1 1 ATOM 2461 O OD1 B ASP A 1 321 ? 4.783 -12.940 -55.321 0.30 23.08 ? 390 ASP A OD1 1 ATOM 2462 O OD2 A ASP A 1 321 ? 4.667 -16.402 -53.304 0.70 26.40 ? 390 ASP A OD2 1 ATOM 2463 O OD2 B ASP A 1 321 ? 4.533 -15.125 -55.308 0.30 24.33 ? 390 ASP A OD2 1 ATOM 2464 N N . SER A 1 322 ? 3.952 -12.486 -50.397 1.00 24.69 ? 391 SER A N 1 ATOM 2465 C CA . SER A 1 322 ? 3.846 -12.502 -48.920 1.00 24.45 ? 391 SER A CA 1 ATOM 2466 C C . SER A 1 322 ? 3.302 -13.814 -48.349 1.00 24.29 ? 391 SER A C 1 ATOM 2467 O O . SER A 1 322 ? 3.226 -13.976 -47.128 1.00 23.76 ? 391 SER A O 1 ATOM 2468 C CB . SER A 1 322 ? 3.009 -11.308 -48.433 1.00 24.43 ? 391 SER A CB 1 ATOM 2469 O OG . SER A 1 322 ? 1.613 -11.458 -48.650 1.00 24.88 ? 391 SER A OG 1 ATOM 2470 N N . ASP A 1 323 ? 2.941 -14.748 -49.222 1.00 23.67 ? 392 ASP A N 1 ATOM 2471 C CA . ASP A 1 323 ? 2.308 -15.988 -48.771 1.00 24.49 ? 392 ASP A CA 1 ATOM 2472 C C . ASP A 1 323 ? 3.256 -16.882 -47.975 1.00 24.22 ? 392 ASP A C 1 ATOM 2473 O O . ASP A 1 323 ? 4.470 -16.896 -48.213 1.00 24.13 ? 392 ASP A O 1 ATOM 2474 C CB . ASP A 1 323 ? 1.735 -16.792 -49.952 1.00 24.70 ? 392 ASP A CB 1 ATOM 2475 C CG . ASP A 1 323 ? 0.406 -16.232 -50.450 1.00 26.81 ? 392 ASP A CG 1 ATOM 2476 O OD1 . ASP A 1 323 ? -0.494 -15.971 -49.623 1.00 30.72 ? 392 ASP A OD1 1 ATOM 2477 O OD2 . ASP A 1 323 ? 0.255 -16.063 -51.672 1.00 29.47 ? 392 ASP A OD2 1 ATOM 2478 N N . ALA A 1 324 ? 2.676 -17.662 -47.070 1.00 23.69 ? 393 ALA A N 1 ATOM 2479 C CA . ALA A 1 324 ? 3.434 -18.600 -46.252 1.00 23.74 ? 393 ALA A CA 1 ATOM 2480 C C . ALA A 1 324 ? 4.187 -19.576 -47.125 1.00 23.73 ? 393 ALA A C 1 ATOM 2481 O O . ALA A 1 324 ? 3.726 -19.953 -48.211 1.00 24.31 ? 393 ALA A O 1 ATOM 2482 C CB . ALA A 1 324 ? 2.516 -19.371 -45.270 1.00 23.24 ? 393 ALA A CB 1 ATOM 2483 N N . LEU A 1 325 ? 5.371 -19.948 -46.651 1.00 23.50 ? 394 LEU A N 1 ATOM 2484 C CA . LEU A 1 325 ? 6.046 -21.151 -47.105 1.00 23.69 ? 394 LEU A CA 1 ATOM 2485 C C . LEU A 1 325 ? 5.298 -22.363 -46.556 1.00 23.66 ? 394 LEU A C 1 ATOM 2486 O O . LEU A 1 325 ? 4.650 -22.288 -45.522 1.00 23.33 ? 394 LEU A O 1 ATOM 2487 C CB . LEU A 1 325 ? 7.498 -21.151 -46.644 1.00 23.82 ? 394 LEU A CB 1 ATOM 2488 C CG . LEU A 1 325 ? 8.580 -20.374 -47.411 1.00 24.20 ? 394 LEU A CG 1 ATOM 2489 C CD1 . LEU A 1 325 ? 8.079 -19.380 -48.435 1.00 25.22 ? 394 LEU A CD1 1 ATOM 2490 C CD2 . LEU A 1 325 ? 9.461 -19.679 -46.433 1.00 25.14 ? 394 LEU A CD2 1 ATOM 2491 N N . ALA A 1 326 ? 5.367 -23.468 -47.280 1.00 23.87 ? 395 ALA A N 1 ATOM 2492 C CA . ALA A 1 326 ? 4.638 -24.695 -46.924 1.00 23.80 ? 395 ALA A CA 1 ATOM 2493 C C . ALA A 1 326 ? 5.502 -25.574 -46.014 1.00 23.74 ? 395 ALA A C 1 ATOM 2494 O O . ALA A 1 326 ? 6.547 -26.058 -46.456 1.00 23.88 ? 395 ALA A O 1 ATOM 2495 C CB . ALA A 1 326 ? 4.256 -25.474 -48.218 1.00 22.73 ? 395 ALA A CB 1 ATOM 2496 N N . LEU A 1 327 ? 5.081 -25.772 -44.758 1.00 23.64 ? 396 LEU A N 1 ATOM 2497 C CA . LEU A 1 327 ? 5.791 -26.691 -43.849 1.00 23.57 ? 396 LEU A CA 1 ATOM 2498 C C . LEU A 1 327 ? 5.838 -28.071 -44.482 1.00 23.53 ? 396 LEU A C 1 ATOM 2499 O O . LEU A 1 327 ? 4.803 -28.633 -44.845 1.00 24.35 ? 396 LEU A O 1 ATOM 2500 C CB . LEU A 1 327 ? 5.120 -26.781 -42.459 1.00 23.92 ? 396 LEU A CB 1 ATOM 2501 C CG . LEU A 1 327 ? 5.851 -27.570 -41.353 1.00 22.93 ? 396 LEU A CG 1 ATOM 2502 C CD1 . LEU A 1 327 ? 7.199 -26.939 -41.059 1.00 22.93 ? 396 LEU A CD1 1 ATOM 2503 C CD2 . LEU A 1 327 ? 5.034 -27.710 -40.058 1.00 22.19 ? 396 LEU A CD2 1 ATOM 2504 N N . SER A 1 328 ? 7.042 -28.603 -44.643 1.00 23.07 ? 397 SER A N 1 ATOM 2505 C CA . SER A 1 328 ? 7.235 -29.963 -45.167 1.00 22.24 ? 397 SER A CA 1 ATOM 2506 C C . SER A 1 328 ? 7.489 -30.989 -44.047 1.00 21.36 ? 397 SER A C 1 ATOM 2507 O O . SER A 1 328 ? 7.014 -32.141 -44.143 1.00 21.31 ? 397 SER A O 1 ATOM 2508 C CB . SER A 1 328 ? 8.377 -29.985 -46.185 1.00 22.38 ? 397 SER A CB 1 ATOM 2509 O OG . SER A 1 328 ? 8.973 -31.264 -46.206 1.00 23.85 ? 397 SER A OG 1 ATOM 2510 N N . GLY A 1 329 ? 8.198 -30.579 -42.983 1.00 19.61 ? 398 GLY A N 1 ATOM 2511 C CA . GLY A 1 329 ? 8.538 -31.498 -41.902 1.00 18.25 ? 398 GLY A CA 1 ATOM 2512 C C . GLY A 1 329 ? 9.513 -30.981 -40.857 1.00 17.47 ? 398 GLY A C 1 ATOM 2513 O O . GLY A 1 329 ? 10.247 -30.038 -41.095 1.00 17.72 ? 398 GLY A O 1 ATOM 2514 N N . VAL A 1 330 ? 9.485 -31.594 -39.683 1.00 16.50 ? 399 VAL A N 1 ATOM 2515 C CA . VAL A 1 330 ? 10.409 -31.302 -38.581 1.00 16.07 ? 399 VAL A CA 1 ATOM 2516 C C . VAL A 1 330 ? 11.659 -32.154 -38.777 1.00 16.59 ? 399 VAL A C 1 ATOM 2517 O O . VAL A 1 330 ? 11.583 -33.369 -38.765 1.00 16.99 ? 399 VAL A O 1 ATOM 2518 C CB . VAL A 1 330 ? 9.716 -31.576 -37.205 1.00 16.03 ? 399 VAL A CB 1 ATOM 2519 C CG1 . VAL A 1 330 ? 10.683 -31.443 -36.016 1.00 13.37 ? 399 VAL A CG1 1 ATOM 2520 C CG2 . VAL A 1 330 ? 8.525 -30.654 -37.063 1.00 14.62 ? 399 VAL A CG2 1 ATOM 2521 N N . MET A 1 331 ? 12.797 -31.500 -39.023 1.00 17.87 ? 400 MET A N 1 ATOM 2522 C CA . MET A 1 331 ? 14.068 -32.168 -39.294 1.00 18.10 ? 400 MET A CA 1 ATOM 2523 C C . MET A 1 331 ? 14.818 -32.382 -37.988 1.00 18.89 ? 400 MET A C 1 ATOM 2524 O O . MET A 1 331 ? 15.529 -33.386 -37.815 1.00 18.84 ? 400 MET A O 1 ATOM 2525 C CB . MET A 1 331 ? 14.924 -31.332 -40.246 1.00 17.69 ? 400 MET A CB 1 ATOM 2526 C CG . MET A 1 331 ? 14.436 -31.330 -41.671 1.00 18.45 ? 400 MET A CG 1 ATOM 2527 S SD . MET A 1 331 ? 15.610 -30.540 -42.809 1.00 19.11 ? 400 MET A SD 1 ATOM 2528 C CE . MET A 1 331 ? 15.597 -28.820 -42.310 1.00 17.88 ? 400 MET A CE 1 ATOM 2529 N N . VAL A 1 332 ? 14.672 -31.418 -37.081 1.00 19.31 ? 401 VAL A N 1 ATOM 2530 C CA . VAL A 1 332 ? 15.208 -31.547 -35.736 1.00 19.88 ? 401 VAL A CA 1 ATOM 2531 C C . VAL A 1 332 ? 14.145 -31.079 -34.746 1.00 20.24 ? 401 VAL A C 1 ATOM 2532 O O . VAL A 1 332 ? 13.566 -29.998 -34.907 1.00 19.66 ? 401 VAL A O 1 ATOM 2533 C CB . VAL A 1 332 ? 16.516 -30.710 -35.571 1.00 19.92 ? 401 VAL A CB 1 ATOM 2534 C CG1 . VAL A 1 332 ? 17.068 -30.825 -34.154 1.00 20.91 ? 401 VAL A CG1 1 ATOM 2535 C CG2 . VAL A 1 332 ? 17.558 -31.131 -36.589 1.00 20.20 ? 401 VAL A CG2 1 ATOM 2536 N N . SER A 1 333 ? 13.892 -31.901 -33.734 1.00 20.96 ? 402 SER A N 1 ATOM 2537 C CA . SER A 1 333 ? 12.902 -31.593 -32.712 1.00 21.72 ? 402 SER A CA 1 ATOM 2538 C C . SER A 1 333 ? 13.310 -30.385 -31.876 1.00 22.19 ? 402 SER A C 1 ATOM 2539 O O . SER A 1 333 ? 14.485 -30.069 -31.751 1.00 22.19 ? 402 SER A O 1 ATOM 2540 C CB . SER A 1 333 ? 12.736 -32.762 -31.742 1.00 22.27 ? 402 SER A CB 1 ATOM 2541 O OG . SER A 1 333 ? 13.456 -32.501 -30.550 1.00 21.68 ? 402 SER A OG 1 ATOM 2542 N N . MET A 1 334 ? 12.324 -29.757 -31.261 1.00 22.81 ? 403 MET A N 1 ATOM 2543 C CA . MET A 1 334 ? 12.553 -28.608 -30.388 1.00 23.92 ? 403 MET A CA 1 ATOM 2544 C C . MET A 1 334 ? 13.507 -28.914 -29.241 1.00 23.30 ? 403 MET A C 1 ATOM 2545 O O . MET A 1 334 ? 14.236 -28.033 -28.797 1.00 23.74 ? 403 MET A O 1 ATOM 2546 C CB . MET A 1 334 ? 11.233 -28.124 -29.786 1.00 24.67 ? 403 MET A CB 1 ATOM 2547 C CG . MET A 1 334 ? 11.359 -26.822 -29.025 1.00 27.36 ? 403 MET A CG 1 ATOM 2548 S SD . MET A 1 334 ? 11.006 -25.430 -30.058 1.00 32.93 ? 403 MET A SD 1 ATOM 2549 C CE . MET A 1 334 ? 9.381 -25.043 -29.423 1.00 29.87 ? 403 MET A CE 1 ATOM 2550 N N . GLU A 1 335 ? 13.489 -30.150 -28.765 1.00 22.53 ? 404 GLU A N 1 ATOM 2551 C CA . GLU A 1 335 ? 14.356 -30.559 -27.665 1.00 22.69 ? 404 GLU A CA 1 ATOM 2552 C C . GLU A 1 335 ? 15.830 -30.700 -28.062 1.00 20.74 ? 404 GLU A C 1 ATOM 2553 O O . GLU A 1 335 ? 16.681 -30.791 -27.182 1.00 20.51 ? 404 GLU A O 1 ATOM 2554 C CB . GLU A 1 335 ? 13.852 -31.878 -27.069 1.00 23.03 ? 404 GLU A CB 1 ATOM 2555 C CG . GLU A 1 335 ? 12.557 -31.729 -26.303 1.00 27.07 ? 404 GLU A CG 1 ATOM 2556 C CD . GLU A 1 335 ? 11.320 -32.183 -27.089 1.00 33.58 ? 404 GLU A CD 1 ATOM 2557 O OE1 . GLU A 1 335 ? 11.251 -31.963 -28.332 1.00 33.69 ? 404 GLU A OE1 1 ATOM 2558 O OE2 . GLU A 1 335 ? 10.406 -32.760 -26.431 1.00 37.21 ? 404 GLU A OE2 1 ATOM 2559 N N . GLU A 1 336 ? 16.116 -30.733 -29.378 1.00 18.70 ? 405 GLU A N 1 ATOM 2560 C CA . GLU A 1 336 ? 17.487 -30.833 -29.895 1.00 16.26 ? 405 GLU A CA 1 ATOM 2561 C C . GLU A 1 336 ? 18.016 -29.489 -30.444 1.00 15.16 ? 405 GLU A C 1 ATOM 2562 O O . GLU A 1 336 ? 17.243 -28.666 -30.955 1.00 13.92 ? 405 GLU A O 1 ATOM 2563 C CB . GLU A 1 336 ? 17.545 -31.890 -30.975 1.00 16.43 ? 405 GLU A CB 1 ATOM 2564 C CG . GLU A 1 336 ? 17.436 -33.341 -30.477 1.00 16.36 ? 405 GLU A CG 1 ATOM 2565 C CD . GLU A 1 336 ? 18.746 -33.919 -29.973 1.00 16.24 ? 405 GLU A CD 1 ATOM 2566 O OE1 . GLU A 1 336 ? 19.818 -33.488 -30.454 1.00 18.83 ? 405 GLU A OE1 1 ATOM 2567 O OE2 . GLU A 1 336 ? 18.702 -34.822 -29.102 1.00 15.20 ? 405 GLU A OE2 1 ATOM 2568 N N . PRO A 1 337 ? 19.332 -29.245 -30.317 1.00 13.21 ? 406 PRO A N 1 ATOM 2569 C CA . PRO A 1 337 ? 19.926 -28.018 -30.843 1.00 12.69 ? 406 PRO A CA 1 ATOM 2570 C C . PRO A 1 337 ? 19.832 -27.885 -32.394 1.00 11.80 ? 406 PRO A C 1 ATOM 2571 O O . PRO A 1 337 ? 19.961 -28.861 -33.094 1.00 10.39 ? 406 PRO A O 1 ATOM 2572 C CB . PRO A 1 337 ? 21.385 -28.162 -30.437 1.00 12.54 ? 406 PRO A CB 1 ATOM 2573 C CG . PRO A 1 337 ? 21.611 -29.597 -30.354 1.00 12.53 ? 406 PRO A CG 1 ATOM 2574 C CD . PRO A 1 337 ? 20.364 -30.160 -29.813 1.00 12.93 ? 406 PRO A CD 1 ATOM 2575 N N . GLY A 1 338 ? 19.598 -26.672 -32.884 1.00 11.80 ? 407 GLY A N 1 ATOM 2576 C CA . GLY A 1 338 ? 19.588 -26.369 -34.324 1.00 11.98 ? 407 GLY A CA 1 ATOM 2577 C C . GLY A 1 338 ? 20.191 -25.004 -34.578 1.00 12.00 ? 407 GLY A C 1 ATOM 2578 O O . GLY A 1 338 ? 19.511 -24.006 -34.375 1.00 12.53 ? 407 GLY A O 1 ATOM 2579 N N . TRP A 1 339 ? 21.469 -24.980 -35.001 1.00 12.38 ? 408 TRP A N 1 ATOM 2580 C CA . TRP A 1 339 ? 22.227 -23.753 -35.237 1.00 12.67 ? 408 TRP A CA 1 ATOM 2581 C C . TRP A 1 339 ? 22.280 -23.551 -36.774 1.00 13.86 ? 408 TRP A C 1 ATOM 2582 O O . TRP A 1 339 ? 21.249 -23.621 -37.416 1.00 14.82 ? 408 TRP A O 1 ATOM 2583 C CB . TRP A 1 339 ? 23.596 -23.815 -34.552 1.00 12.53 ? 408 TRP A CB 1 ATOM 2584 C CG . TRP A 1 339 ? 23.482 -23.825 -33.039 1.00 12.46 ? 408 TRP A CG 1 ATOM 2585 C CD1 . TRP A 1 339 ? 22.605 -24.574 -32.297 1.00 12.59 ? 408 TRP A CD1 1 ATOM 2586 C CD2 . TRP A 1 339 ? 24.234 -23.050 -32.087 1.00 13.44 ? 408 TRP A CD2 1 ATOM 2587 N NE1 . TRP A 1 339 ? 22.757 -24.312 -30.966 1.00 13.62 ? 408 TRP A NE1 1 ATOM 2588 C CE2 . TRP A 1 339 ? 23.746 -23.384 -30.798 1.00 13.59 ? 408 TRP A CE2 1 ATOM 2589 C CE3 . TRP A 1 339 ? 25.254 -22.102 -32.194 1.00 14.31 ? 408 TRP A CE3 1 ATOM 2590 C CZ2 . TRP A 1 339 ? 24.246 -22.813 -29.621 1.00 13.72 ? 408 TRP A CZ2 1 ATOM 2591 C CZ3 . TRP A 1 339 ? 25.751 -21.514 -31.020 1.00 14.29 ? 408 TRP A CZ3 1 ATOM 2592 C CH2 . TRP A 1 339 ? 25.240 -21.876 -29.746 1.00 15.09 ? 408 TRP A CH2 1 ATOM 2593 N N . TYR A 1 340 ? 23.431 -23.350 -37.381 1.00 14.71 ? 409 TYR A N 1 ATOM 2594 C CA . TYR A 1 340 ? 23.456 -22.951 -38.804 1.00 15.70 ? 409 TYR A CA 1 ATOM 2595 C C . TYR A 1 340 ? 22.825 -23.968 -39.761 1.00 15.69 ? 409 TYR A C 1 ATOM 2596 O O . TYR A 1 340 ? 22.819 -25.150 -39.485 1.00 17.06 ? 409 TYR A O 1 ATOM 2597 C CB . TYR A 1 340 ? 24.906 -22.677 -39.234 1.00 15.67 ? 409 TYR A CB 1 ATOM 2598 C CG . TYR A 1 340 ? 25.456 -21.330 -38.823 1.00 15.99 ? 409 TYR A CG 1 ATOM 2599 C CD1 . TYR A 1 340 ? 24.718 -20.458 -38.012 1.00 16.50 ? 409 TYR A CD1 1 ATOM 2600 C CD2 . TYR A 1 340 ? 26.727 -20.938 -39.206 1.00 15.13 ? 409 TYR A CD2 1 ATOM 2601 C CE1 . TYR A 1 340 ? 25.228 -19.217 -37.624 1.00 16.82 ? 409 TYR A CE1 1 ATOM 2602 C CE2 . TYR A 1 340 ? 27.240 -19.696 -38.820 1.00 17.46 ? 409 TYR A CE2 1 ATOM 2603 C CZ . TYR A 1 340 ? 26.484 -18.841 -38.017 1.00 17.44 ? 409 TYR A CZ 1 ATOM 2604 O OH . TYR A 1 340 ? 26.964 -17.597 -37.622 1.00 17.65 ? 409 TYR A OH 1 ATOM 2605 N N . SER A 1 341 ? 22.287 -23.515 -40.878 1.00 15.67 ? 410 SER A N 1 ATOM 2606 C CA . SER A 1 341 ? 21.909 -24.454 -41.950 1.00 15.76 ? 410 SER A CA 1 ATOM 2607 C C . SER A 1 341 ? 22.418 -23.986 -43.298 1.00 15.70 ? 410 SER A C 1 ATOM 2608 O O . SER A 1 341 ? 22.710 -22.816 -43.468 1.00 16.43 ? 410 SER A O 1 ATOM 2609 C CB . SER A 1 341 ? 20.395 -24.763 -41.967 1.00 15.89 ? 410 SER A CB 1 ATOM 2610 O OG . SER A 1 341 ? 19.561 -23.615 -41.855 1.00 16.54 ? 410 SER A OG 1 ATOM 2611 N N . PHE A 1 342 ? 22.558 -24.903 -44.242 1.00 16.20 ? 411 PHE A N 1 ATOM 2612 C CA . PHE A 1 342 ? 23.055 -24.575 -45.603 1.00 16.50 ? 411 PHE A CA 1 ATOM 2613 C C . PHE A 1 342 ? 22.434 -25.490 -46.619 1.00 16.39 ? 411 PHE A C 1 ATOM 2614 O O . PHE A 1 342 ? 21.960 -26.572 -46.283 1.00 16.22 ? 411 PHE A O 1 ATOM 2615 C CB . PHE A 1 342 ? 24.576 -24.782 -45.670 1.00 16.97 ? 411 PHE A CB 1 ATOM 2616 C CG . PHE A 1 342 ? 25.021 -26.132 -45.116 1.00 18.59 ? 411 PHE A CG 1 ATOM 2617 C CD1 . PHE A 1 342 ? 25.179 -26.314 -43.729 1.00 18.10 ? 411 PHE A CD1 1 ATOM 2618 C CD2 . PHE A 1 342 ? 25.235 -27.211 -45.966 1.00 18.11 ? 411 PHE A CD2 1 ATOM 2619 C CE1 . PHE A 1 342 ? 25.559 -27.548 -43.208 1.00 17.84 ? 411 PHE A CE1 1 ATOM 2620 C CE2 . PHE A 1 342 ? 25.617 -28.440 -45.470 1.00 18.92 ? 411 PHE A CE2 1 ATOM 2621 C CZ . PHE A 1 342 ? 25.784 -28.615 -44.055 1.00 17.61 ? 411 PHE A CZ 1 ATOM 2622 N N . GLY A 1 343 ? 22.479 -25.061 -47.881 1.00 17.26 ? 412 GLY A N 1 ATOM 2623 C CA . GLY A 1 343 ? 22.110 -25.884 -49.027 1.00 16.64 ? 412 GLY A CA 1 ATOM 2624 C C . GLY A 1 343 ? 23.312 -26.345 -49.827 1.00 17.25 ? 412 GLY A C 1 ATOM 2625 O O . GLY A 1 343 ? 24.399 -25.761 -49.734 1.00 17.80 ? 412 GLY A O 1 ATOM 2626 N N . PHE A 1 344 ? 23.114 -27.434 -50.569 1.00 17.05 ? 413 PHE A N 1 ATOM 2627 C CA . PHE A 1 344 ? 24.106 -27.986 -51.480 1.00 17.16 ? 413 PHE A CA 1 ATOM 2628 C C . PHE A 1 344 ? 23.485 -28.960 -52.453 1.00 17.03 ? 413 PHE A C 1 ATOM 2629 O O . PHE A 1 344 ? 22.340 -29.361 -52.299 1.00 16.87 ? 413 PHE A O 1 ATOM 2630 C CB . PHE A 1 344 ? 25.262 -28.663 -50.757 1.00 17.12 ? 413 PHE A CB 1 ATOM 2631 C CG . PHE A 1 344 ? 24.894 -29.890 -49.982 1.00 16.51 ? 413 PHE A CG 1 ATOM 2632 C CD1 . PHE A 1 344 ? 25.085 -31.164 -50.523 1.00 16.78 ? 413 PHE A CD1 1 ATOM 2633 C CD2 . PHE A 1 344 ? 24.439 -29.779 -48.666 1.00 16.95 ? 413 PHE A CD2 1 ATOM 2634 C CE1 . PHE A 1 344 ? 24.783 -32.322 -49.777 1.00 16.29 ? 413 PHE A CE1 1 ATOM 2635 C CE2 . PHE A 1 344 ? 24.138 -30.927 -47.899 1.00 14.69 ? 413 PHE A CE2 1 ATOM 2636 C CZ . PHE A 1 344 ? 24.313 -32.184 -48.433 1.00 15.51 ? 413 PHE A CZ 1 ATOM 2637 N N . GLU A 1 345 ? 24.244 -29.331 -53.471 1.00 17.54 ? 414 GLU A N 1 ATOM 2638 C CA . GLU A 1 345 ? 23.722 -30.226 -54.501 1.00 17.82 ? 414 GLU A CA 1 ATOM 2639 C C . GLU A 1 345 ? 24.657 -31.347 -54.900 1.00 17.12 ? 414 GLU A C 1 ATOM 2640 O O . GLU A 1 345 ? 25.791 -31.116 -55.222 1.00 16.93 ? 414 GLU A O 1 ATOM 2641 C CB . GLU A 1 345 ? 23.317 -29.422 -55.719 1.00 17.90 ? 414 GLU A CB 1 ATOM 2642 C CG . GLU A 1 345 ? 22.070 -28.623 -55.480 1.00 18.80 ? 414 GLU A CG 1 ATOM 2643 C CD . GLU A 1 345 ? 21.645 -27.831 -56.709 1.00 22.56 ? 414 GLU A CD 1 ATOM 2644 O OE1 . GLU A 1 345 ? 21.159 -26.684 -56.506 1.00 22.50 ? 414 GLU A OE1 1 ATOM 2645 O OE2 . GLU A 1 345 ? 21.806 -28.358 -57.851 1.00 19.10 ? 414 GLU A OE2 1 ATOM 2646 N N . ILE A 1 346 ? 24.135 -32.567 -54.920 1.00 17.43 ? 415 ILE A N 1 ATOM 2647 C CA . ILE A 1 346 ? 24.911 -33.745 -55.254 1.00 17.71 ? 415 ILE A CA 1 ATOM 2648 C C . ILE A 1 346 ? 24.664 -34.025 -56.730 1.00 18.55 ? 415 ILE A C 1 ATOM 2649 O O . ILE A 1 346 ? 23.552 -33.878 -57.200 1.00 18.88 ? 415 ILE A O 1 ATOM 2650 C CB . ILE A 1 346 ? 24.487 -34.940 -54.404 1.00 17.62 ? 415 ILE A CB 1 ATOM 2651 C CG1 . ILE A 1 346 ? 24.355 -34.529 -52.925 1.00 16.70 ? 415 ILE A CG1 1 ATOM 2652 C CG2 . ILE A 1 346 ? 25.480 -36.073 -54.544 1.00 18.27 ? 415 ILE A CG2 1 ATOM 2653 C CD1 . ILE A 1 346 ? 23.652 -35.590 -52.066 1.00 14.53 ? 415 ILE A CD1 1 ATOM 2654 N N . LYS A 1 347 ? 25.712 -34.374 -57.464 1.00 18.95 ? 416 LYS A N 1 ATOM 2655 C CA . LYS A 1 347 ? 25.577 -34.704 -58.874 1.00 19.87 ? 416 LYS A CA 1 ATOM 2656 C C . LYS A 1 347 ? 25.298 -36.198 -59.054 1.00 19.55 ? 416 LYS A C 1 ATOM 2657 O O . LYS A 1 347 ? 26.154 -37.033 -58.836 1.00 19.58 ? 416 LYS A O 1 ATOM 2658 C CB . LYS A 1 347 ? 26.843 -34.294 -59.645 1.00 20.53 ? 416 LYS A CB 1 ATOM 2659 C CG . LYS A 1 347 ? 27.169 -32.785 -59.561 1.00 22.81 ? 416 LYS A CG 1 ATOM 2660 C CD . LYS A 1 347 ? 28.219 -32.366 -60.592 1.00 26.81 ? 416 LYS A CD 1 ATOM 2661 C CE . LYS A 1 347 ? 27.612 -31.962 -61.963 1.00 28.64 ? 416 LYS A CE 1 ATOM 2662 N NZ . LYS A 1 347 ? 28.439 -32.446 -63.151 1.00 27.47 ? 416 LYS A NZ 1 ATOM 2663 N N . ASP A 1 348 ? 24.074 -36.522 -59.422 1.00 19.93 ? 417 ASP A N 1 ATOM 2664 C CA . ASP A 1 348 ? 23.738 -37.838 -59.933 1.00 20.57 ? 417 ASP A CA 1 ATOM 2665 C C . ASP A 1 348 ? 24.190 -37.853 -61.416 1.00 21.21 ? 417 ASP A C 1 ATOM 2666 O O . ASP A 1 348 ? 24.767 -36.883 -61.920 1.00 19.98 ? 417 ASP A O 1 ATOM 2667 C CB . ASP A 1 348 ? 22.226 -38.069 -59.762 1.00 20.40 ? 417 ASP A CB 1 ATOM 2668 C CG . ASP A 1 348 ? 21.783 -39.489 -60.071 1.00 20.67 ? 417 ASP A CG 1 ATOM 2669 O OD1 . ASP A 1 348 ? 22.617 -40.406 -60.050 1.00 20.06 ? 417 ASP A OD1 1 ATOM 2670 O OD2 . ASP A 1 348 ? 20.581 -39.679 -60.364 1.00 21.33 ? 417 ASP A OD2 1 ATOM 2671 N N . LYS A 1 349 ? 23.939 -38.956 -62.107 1.00 22.74 ? 418 LYS A N 1 ATOM 2672 C CA . LYS A 1 349 ? 24.532 -39.163 -63.434 1.00 23.88 ? 418 LYS A CA 1 ATOM 2673 C C . LYS A 1 349 ? 24.060 -38.145 -64.444 1.00 23.52 ? 418 LYS A C 1 ATOM 2674 O O . LYS A 1 349 ? 24.866 -37.681 -65.224 1.00 23.19 ? 418 LYS A O 1 ATOM 2675 C CB . LYS A 1 349 ? 24.284 -40.580 -63.958 1.00 24.47 ? 418 LYS A CB 1 ATOM 2676 C CG . LYS A 1 349 ? 25.057 -41.668 -63.202 1.00 27.52 ? 418 LYS A CG 1 ATOM 2677 C CD . LYS A 1 349 ? 24.778 -43.073 -63.793 1.00 32.34 ? 418 LYS A CD 1 ATOM 2678 C CE . LYS A 1 349 ? 25.702 -43.454 -64.981 1.00 33.68 ? 418 LYS A CE 1 ATOM 2679 N NZ . LYS A 1 349 ? 26.920 -44.213 -64.504 1.00 35.11 ? 418 LYS A NZ 1 ATOM 2680 N N . LYS A 1 350 ? 22.773 -37.795 -64.434 1.00 23.78 ? 419 LYS A N 1 ATOM 2681 C CA . LYS A 1 350 ? 22.228 -36.834 -65.415 1.00 23.93 ? 419 LYS A CA 1 ATOM 2682 C C . LYS A 1 350 ? 21.414 -35.672 -64.803 1.00 23.52 ? 419 LYS A C 1 ATOM 2683 O O . LYS A 1 350 ? 20.870 -34.850 -65.545 1.00 22.14 ? 419 LYS A O 1 ATOM 2684 C CB . LYS A 1 350 ? 21.371 -37.586 -66.450 1.00 24.98 ? 419 LYS A CB 1 ATOM 2685 C CG . LYS A 1 350 ? 22.148 -38.551 -67.376 1.00 26.02 ? 419 LYS A CG 1 ATOM 2686 C CD . LYS A 1 350 ? 21.205 -39.260 -68.355 1.00 29.10 ? 419 LYS A CD 1 ATOM 2687 C CE . LYS A 1 350 ? 20.456 -40.402 -67.668 1.00 31.42 ? 419 LYS A CE 1 ATOM 2688 N NZ . LYS A 1 350 ? 19.436 -41.075 -68.534 1.00 32.16 ? 419 LYS A NZ 1 ATOM 2689 N N . CYS A 1 351 ? 21.357 -35.590 -63.463 1.00 22.62 ? 420 CYS A N 1 ATOM 2690 C CA . CYS A 1 351 ? 20.588 -34.548 -62.771 1.00 22.30 ? 420 CYS A CA 1 ATOM 2691 C C . CYS A 1 351 ? 21.136 -34.211 -61.388 1.00 21.84 ? 420 CYS A C 1 ATOM 2692 O O . CYS A 1 351 ? 21.868 -34.994 -60.802 1.00 22.03 ? 420 CYS A O 1 ATOM 2693 C CB . CYS A 1 351 ? 19.133 -34.979 -62.627 1.00 22.18 ? 420 CYS A CB 1 ATOM 2694 S SG . CYS A 1 351 ? 18.926 -36.571 -61.864 1.00 23.55 ? 420 CYS A SG 1 ATOM 2695 N N . ASP A 1 352 ? 20.741 -33.057 -60.856 1.00 21.59 ? 421 ASP A N 1 ATOM 2696 C CA . ASP A 1 352 ? 21.225 -32.594 -59.544 1.00 21.60 ? 421 ASP A CA 1 ATOM 2697 C C . ASP A 1 352 ? 20.240 -32.861 -58.389 1.00 20.68 ? 421 ASP A C 1 ATOM 2698 O O . ASP A 1 352 ? 19.035 -32.600 -58.504 1.00 19.65 ? 421 ASP A O 1 ATOM 2699 C CB . ASP A 1 352 ? 21.565 -31.103 -59.604 1.00 21.62 ? 421 ASP A CB 1 ATOM 2700 C CG . ASP A 1 352 ? 22.563 -30.770 -60.698 1.00 23.43 ? 421 ASP A CG 1 ATOM 2701 O OD1 . ASP A 1 352 ? 23.210 -31.690 -61.244 1.00 25.41 ? 421 ASP A OD1 1 ATOM 2702 O OD2 . ASP A 1 352 ? 22.692 -29.567 -61.013 1.00 26.56 ? 421 ASP A OD2 1 ATOM 2703 N N . VAL A 1 353 ? 20.770 -33.351 -57.269 1.00 20.19 ? 422 VAL A N 1 ATOM 2704 C CA . VAL A 1 353 ? 19.945 -33.669 -56.101 1.00 19.99 ? 422 VAL A CA 1 ATOM 2705 C C . VAL A 1 353 ? 20.079 -32.610 -55.002 1.00 20.67 ? 422 VAL A C 1 ATOM 2706 O O . VAL A 1 353 ? 21.108 -32.549 -54.343 1.00 21.41 ? 422 VAL A O 1 ATOM 2707 C CB . VAL A 1 353 ? 20.321 -35.042 -55.526 1.00 20.39 ? 422 VAL A CB 1 ATOM 2708 C CG1 . VAL A 1 353 ? 19.654 -35.274 -54.159 1.00 19.07 ? 422 VAL A CG1 1 ATOM 2709 C CG2 . VAL A 1 353 ? 19.967 -36.182 -56.534 1.00 18.32 ? 422 VAL A CG2 1 ATOM 2710 N N . PRO A 1 354 ? 19.027 -31.805 -54.768 1.00 20.32 ? 423 PRO A N 1 ATOM 2711 C CA . PRO A 1 354 ? 19.105 -30.775 -53.736 1.00 20.35 ? 423 PRO A CA 1 ATOM 2712 C C . PRO A 1 354 ? 19.097 -31.306 -52.290 1.00 20.46 ? 423 PRO A C 1 ATOM 2713 O O . PRO A 1 354 ? 18.404 -32.276 -51.984 1.00 20.66 ? 423 PRO A O 1 ATOM 2714 C CB . PRO A 1 354 ? 17.865 -29.889 -53.996 1.00 20.34 ? 423 PRO A CB 1 ATOM 2715 C CG . PRO A 1 354 ? 17.026 -30.586 -54.990 1.00 20.31 ? 423 PRO A CG 1 ATOM 2716 C CD . PRO A 1 354 ? 17.696 -31.866 -55.402 1.00 20.66 ? 423 PRO A CD 1 ATOM 2717 N N . CYS A 1 355 ? 19.868 -30.655 -51.423 1.00 20.17 ? 424 CYS A N 1 ATOM 2718 C CA . CYS A 1 355 ? 20.019 -31.073 -50.038 1.00 20.29 ? 424 CYS A CA 1 ATOM 2719 C C . CYS A 1 355 ? 20.176 -29.911 -49.083 1.00 19.59 ? 424 CYS A C 1 ATOM 2720 O O . CYS A 1 355 ? 20.594 -28.846 -49.484 1.00 18.88 ? 424 CYS A O 1 ATOM 2721 C CB . CYS A 1 355 ? 21.257 -31.931 -49.866 1.00 20.92 ? 424 CYS A CB 1 ATOM 2722 S SG . CYS A 1 355 ? 21.295 -33.409 -50.773 1.00 22.11 ? 424 CYS A SG 1 ATOM 2723 N N . ILE A 1 356 ? 19.870 -30.156 -47.808 1.00 19.56 ? 425 ILE A N 1 ATOM 2724 C CA . ILE A 1 356 ? 20.025 -29.149 -46.741 1.00 19.18 ? 425 ILE A CA 1 ATOM 2725 C C . ILE A 1 356 ? 20.784 -29.754 -45.567 1.00 18.42 ? 425 ILE A C 1 ATOM 2726 O O . ILE A 1 356 ? 20.466 -30.845 -45.089 1.00 18.60 ? 425 ILE A O 1 ATOM 2727 C CB . ILE A 1 356 ? 18.656 -28.606 -46.250 1.00 19.30 ? 425 ILE A CB 1 ATOM 2728 C CG1 . ILE A 1 356 ? 17.983 -27.759 -47.340 1.00 20.50 ? 425 ILE A CG1 1 ATOM 2729 C CG2 . ILE A 1 356 ? 18.805 -27.784 -44.953 1.00 19.41 ? 425 ILE A CG2 1 ATOM 2730 C CD1 . ILE A 1 356 ? 18.139 -26.254 -47.202 1.00 22.20 ? 425 ILE A CD1 1 ATOM 2731 N N . GLY A 1 357 ? 21.807 -29.050 -45.112 1.00 17.49 ? 426 GLY A N 1 ATOM 2732 C CA . GLY A 1 357 ? 22.577 -29.499 -43.964 1.00 16.97 ? 426 GLY A CA 1 ATOM 2733 C C . GLY A 1 357 ? 22.171 -28.696 -42.761 1.00 16.69 ? 426 GLY A C 1 ATOM 2734 O O . GLY A 1 357 ? 21.680 -27.588 -42.905 1.00 16.24 ? 426 GLY A O 1 ATOM 2735 N N . ILE A 1 358 ? 22.395 -29.264 -41.576 1.00 16.79 ? 427 ILE A N 1 ATOM 2736 C CA . ILE A 1 358 ? 22.040 -28.639 -40.311 1.00 16.29 ? 427 ILE A CA 1 ATOM 2737 C C . ILE A 1 358 ? 23.159 -28.829 -39.300 1.00 16.39 ? 427 ILE A C 1 ATOM 2738 O O . ILE A 1 358 ? 23.480 -29.967 -38.938 1.00 16.23 ? 427 ILE A O 1 ATOM 2739 C CB . ILE A 1 358 ? 20.806 -29.291 -39.704 1.00 16.36 ? 427 ILE A CB 1 ATOM 2740 C CG1 . ILE A 1 358 ? 19.619 -29.244 -40.654 1.00 15.93 ? 427 ILE A CG1 1 ATOM 2741 C CG2 . ILE A 1 358 ? 20.445 -28.609 -38.356 1.00 17.94 ? 427 ILE A CG2 1 ATOM 2742 C CD1 . ILE A 1 358 ? 18.606 -30.308 -40.366 1.00 14.49 ? 427 ILE A CD1 1 ATOM 2743 N N . GLU A 1 359 ? 23.724 -27.715 -38.833 1.00 15.82 ? 428 GLU A N 1 ATOM 2744 C CA . GLU A 1 359 ? 24.690 -27.704 -37.724 1.00 15.94 ? 428 GLU A CA 1 ATOM 2745 C C . GLU A 1 359 ? 23.977 -27.839 -36.392 1.00 15.27 ? 428 GLU A C 1 ATOM 2746 O O . GLU A 1 359 ? 23.139 -27.003 -36.046 1.00 16.42 ? 428 GLU A O 1 ATOM 2747 C CB . GLU A 1 359 ? 25.480 -26.387 -37.745 1.00 15.42 ? 428 GLU A CB 1 ATOM 2748 C CG . GLU A 1 359 ? 26.625 -26.307 -36.764 1.00 15.39 ? 428 GLU A CG 1 ATOM 2749 C CD . GLU A 1 359 ? 27.094 -24.888 -36.491 1.00 13.91 ? 428 GLU A CD 1 ATOM 2750 O OE1 . GLU A 1 359 ? 26.264 -23.945 -36.486 1.00 14.95 ? 428 GLU A OE1 1 ATOM 2751 O OE2 . GLU A 1 359 ? 28.300 -24.713 -36.256 1.00 16.65 ? 428 GLU A OE2 1 ATOM 2752 N N . MET A 1 360 ? 24.295 -28.881 -35.640 1.00 15.07 ? 429 MET A N 1 ATOM 2753 C CA . MET A 1 360 ? 23.648 -29.134 -34.343 1.00 14.05 ? 429 MET A CA 1 ATOM 2754 C C . MET A 1 360 ? 24.659 -28.956 -33.205 1.00 13.49 ? 429 MET A C 1 ATOM 2755 O O . MET A 1 360 ? 25.391 -29.889 -32.835 1.00 12.89 ? 429 MET A O 1 ATOM 2756 C CB . MET A 1 360 ? 23.035 -30.541 -34.329 1.00 14.43 ? 429 MET A CB 1 ATOM 2757 C CG . MET A 1 360 ? 22.028 -30.773 -35.473 1.00 15.61 ? 429 MET A CG 1 ATOM 2758 S SD . MET A 1 360 ? 21.312 -32.426 -35.659 1.00 18.93 ? 429 MET A SD 1 ATOM 2759 C CE . MET A 1 360 ? 20.569 -32.633 -34.027 1.00 15.54 ? 429 MET A CE 1 ATOM 2760 N N . VAL A 1 361 ? 24.738 -27.757 -32.656 1.00 12.83 ? 430 VAL A N 1 ATOM 2761 C CA . VAL A 1 361 ? 25.860 -27.472 -31.750 1.00 13.06 ? 430 VAL A CA 1 ATOM 2762 C C . VAL A 1 361 ? 25.638 -28.059 -30.333 1.00 14.26 ? 430 VAL A C 1 ATOM 2763 O O . VAL A 1 361 ? 24.532 -27.985 -29.773 1.00 13.73 ? 430 VAL A O 1 ATOM 2764 C CB . VAL A 1 361 ? 26.161 -25.961 -31.678 1.00 12.90 ? 430 VAL A CB 1 ATOM 2765 C CG1 . VAL A 1 361 ? 27.039 -25.641 -30.473 1.00 12.11 ? 430 VAL A CG1 1 ATOM 2766 C CG2 . VAL A 1 361 ? 26.799 -25.479 -32.976 1.00 10.04 ? 430 VAL A CG2 1 ATOM 2767 N N . HIS A 1 362 ? 26.699 -28.657 -29.792 1.00 15.57 ? 431 HIS A N 1 ATOM 2768 C CA . HIS A 1 362 ? 26.759 -29.091 -28.384 1.00 16.73 ? 431 HIS A CA 1 ATOM 2769 C C . HIS A 1 362 ? 27.220 -27.892 -27.544 1.00 17.88 ? 431 HIS A C 1 ATOM 2770 O O . HIS A 1 362 ? 28.399 -27.547 -27.509 1.00 18.17 ? 431 HIS A O 1 ATOM 2771 C CB . HIS A 1 362 ? 27.690 -30.320 -28.232 1.00 16.81 ? 431 HIS A CB 1 ATOM 2772 C CG . HIS A 1 362 ? 27.440 -31.393 -29.262 1.00 15.76 ? 431 HIS A CG 1 ATOM 2773 N ND1 . HIS A 1 362 ? 28.131 -31.461 -30.455 1.00 17.56 ? 431 HIS A ND1 1 ATOM 2774 C CD2 . HIS A 1 362 ? 26.529 -32.394 -29.304 1.00 13.62 ? 431 HIS A CD2 1 ATOM 2775 C CE1 . HIS A 1 362 ? 27.686 -32.485 -31.168 1.00 15.81 ? 431 HIS A CE1 1 ATOM 2776 N NE2 . HIS A 1 362 ? 26.714 -33.069 -30.493 1.00 15.58 ? 431 HIS A NE2 1 ATOM 2777 N N . ASP A 1 363 ? 26.279 -27.239 -26.883 1.00 18.84 ? 432 ASP A N 1 ATOM 2778 C CA . ASP A 1 363 ? 26.589 -26.035 -26.144 1.00 19.55 ? 432 ASP A CA 1 ATOM 2779 C C . ASP A 1 363 ? 26.346 -26.169 -24.629 1.00 20.38 ? 432 ASP A C 1 ATOM 2780 O O . ASP A 1 363 ? 25.197 -26.253 -24.183 1.00 20.32 ? 432 ASP A O 1 ATOM 2781 C CB . ASP A 1 363 ? 25.734 -24.900 -26.675 1.00 19.47 ? 432 ASP A CB 1 ATOM 2782 C CG . ASP A 1 363 ? 26.118 -23.566 -26.079 1.00 20.14 ? 432 ASP A CG 1 ATOM 2783 O OD1 . ASP A 1 363 ? 27.273 -23.451 -25.600 1.00 24.37 ? 432 ASP A OD1 1 ATOM 2784 O OD2 . ASP A 1 363 ? 25.280 -22.639 -26.095 1.00 17.51 ? 432 ASP A OD2 1 ATOM 2785 N N . GLY A 1 364 ? 27.426 -26.159 -23.849 1.00 20.64 ? 433 GLY A N 1 ATOM 2786 C CA . GLY A 1 364 ? 27.329 -26.107 -22.380 1.00 20.91 ? 433 GLY A CA 1 ATOM 2787 C C . GLY A 1 364 ? 27.888 -24.806 -21.817 1.00 21.15 ? 433 GLY A C 1 ATOM 2788 O O . GLY A 1 364 ? 28.142 -24.685 -20.618 1.00 21.47 ? 433 GLY A O 1 ATOM 2789 N N . GLY A 1 365 ? 28.075 -23.812 -22.674 1.00 21.66 ? 434 GLY A N 1 ATOM 2790 C CA . GLY A 1 365 ? 28.703 -22.565 -22.240 1.00 21.97 ? 434 GLY A CA 1 ATOM 2791 C C . GLY A 1 365 ? 30.201 -22.601 -22.429 1.00 22.52 ? 434 GLY A C 1 ATOM 2792 O O . GLY A 1 365 ? 30.765 -23.623 -22.790 1.00 21.98 ? 434 GLY A O 1 ATOM 2793 N N . LYS A 1 366 ? 30.852 -21.489 -22.123 1.00 24.12 ? 435 LYS A N 1 ATOM 2794 C CA . LYS A 1 366 ? 32.288 -21.320 -22.384 1.00 25.23 ? 435 LYS A CA 1 ATOM 2795 C C . LYS A 1 366 ? 33.251 -22.043 -21.431 1.00 24.81 ? 435 LYS A C 1 ATOM 2796 O O . LYS A 1 366 ? 34.464 -21.939 -21.613 1.00 25.00 ? 435 LYS A O 1 ATOM 2797 C CB . LYS A 1 366 ? 32.642 -19.822 -22.396 1.00 25.62 ? 435 LYS A CB 1 ATOM 2798 C CG . LYS A 1 366 ? 32.646 -19.171 -21.016 1.00 27.99 ? 435 LYS A CG 1 ATOM 2799 C CD . LYS A 1 366 ? 32.837 -17.662 -21.097 1.00 30.35 ? 435 LYS A CD 1 ATOM 2800 C CE . LYS A 1 366 ? 33.041 -17.054 -19.688 1.00 32.72 ? 435 LYS A CE 1 ATOM 2801 N NZ . LYS A 1 366 ? 31.761 -16.840 -18.898 1.00 33.21 ? 435 LYS A NZ 1 ATOM 2802 N N . GLU A 1 367 ? 32.740 -22.752 -20.425 1.00 24.45 ? 436 GLU A N 1 ATOM 2803 C CA . GLU A 1 367 ? 33.603 -23.469 -19.463 1.00 23.73 ? 436 GLU A CA 1 ATOM 2804 C C . GLU A 1 367 ? 33.641 -24.965 -19.737 1.00 22.88 ? 436 GLU A C 1 ATOM 2805 O O . GLU A 1 367 ? 33.984 -25.743 -18.829 1.00 23.26 ? 436 GLU A O 1 ATOM 2806 C CB . GLU A 1 367 ? 33.120 -23.232 -18.017 1.00 24.39 ? 436 GLU A CB 1 ATOM 2807 C CG . GLU A 1 367 ? 32.800 -21.773 -17.684 1.00 25.25 ? 436 GLU A CG 1 ATOM 2808 C CD . GLU A 1 367 ? 34.031 -20.914 -17.489 1.00 27.56 ? 436 GLU A CD 1 ATOM 2809 O OE1 . GLU A 1 367 ? 35.133 -21.473 -17.373 1.00 30.82 ? 436 GLU A OE1 1 ATOM 2810 O OE2 . GLU A 1 367 ? 33.896 -19.671 -17.442 1.00 29.40 ? 436 GLU A OE2 1 ATOM 2811 N N . THR A 1 368 ? 33.195 -25.363 -20.940 1.00 21.48 ? 437 THR A N 1 ATOM 2812 C CA . THR A 1 368 ? 33.507 -26.661 -21.551 1.00 20.81 ? 437 THR A CA 1 ATOM 2813 C C . THR A 1 368 ? 33.687 -26.566 -23.061 1.00 19.29 ? 437 THR A C 1 ATOM 2814 O O . THR A 1 368 ? 33.652 -25.484 -23.655 1.00 17.61 ? 437 THR A O 1 ATOM 2815 C CB . THR A 1 368 ? 32.430 -27.784 -21.405 1.00 20.81 ? 437 THR A CB 1 ATOM 2816 O OG1 . THR A 1 368 ? 31.147 -27.253 -21.065 1.00 23.60 ? 437 THR A OG1 1 ATOM 2817 C CG2 . THR A 1 368 ? 32.884 -28.800 -20.438 1.00 22.11 ? 437 THR A CG2 1 ATOM 2818 N N . TRP A 1 369 ? 33.869 -27.751 -23.637 1.00 17.20 ? 438 TRP A N 1 ATOM 2819 C CA . TRP A 1 369 ? 34.042 -27.925 -25.052 1.00 17.08 ? 438 TRP A CA 1 ATOM 2820 C C . TRP A 1 369 ? 32.845 -27.431 -25.874 1.00 16.26 ? 438 TRP A C 1 ATOM 2821 O O . TRP A 1 369 ? 31.715 -27.539 -25.440 1.00 15.78 ? 438 TRP A O 1 ATOM 2822 C CB . TRP A 1 369 ? 34.423 -29.392 -25.345 1.00 17.33 ? 438 TRP A CB 1 ATOM 2823 C CG . TRP A 1 369 ? 33.375 -30.418 -25.141 1.00 16.69 ? 438 TRP A CG 1 ATOM 2824 C CD1 . TRP A 1 369 ? 33.073 -31.089 -23.982 1.00 20.40 ? 438 TRP A CD1 1 ATOM 2825 C CD2 . TRP A 1 369 ? 32.523 -30.945 -26.143 1.00 18.45 ? 438 TRP A CD2 1 ATOM 2826 N NE1 . TRP A 1 369 ? 32.055 -31.985 -24.209 1.00 20.64 ? 438 TRP A NE1 1 ATOM 2827 C CE2 . TRP A 1 369 ? 31.695 -31.907 -25.528 1.00 19.67 ? 438 TRP A CE2 1 ATOM 2828 C CE3 . TRP A 1 369 ? 32.365 -30.685 -27.514 1.00 16.17 ? 438 TRP A CE3 1 ATOM 2829 C CZ2 . TRP A 1 369 ? 30.728 -32.608 -26.236 1.00 20.30 ? 438 TRP A CZ2 1 ATOM 2830 C CZ3 . TRP A 1 369 ? 31.418 -31.366 -28.199 1.00 16.92 ? 438 TRP A CZ3 1 ATOM 2831 C CH2 . TRP A 1 369 ? 30.613 -32.333 -27.571 1.00 18.73 ? 438 TRP A CH2 1 ATOM 2832 N N . HIS A 1 370 ? 33.123 -26.888 -27.058 1.00 15.70 ? 439 HIS A N 1 ATOM 2833 C CA . HIS A 1 370 ? 32.089 -26.351 -27.948 1.00 15.83 ? 439 HIS A CA 1 ATOM 2834 C C . HIS A 1 370 ? 32.326 -26.846 -29.364 1.00 15.79 ? 439 HIS A C 1 ATOM 2835 O O . HIS A 1 370 ? 33.267 -26.454 -30.014 1.00 14.49 ? 439 HIS A O 1 ATOM 2836 C CB . HIS A 1 370 ? 32.086 -24.812 -27.928 1.00 15.94 ? 439 HIS A CB 1 ATOM 2837 C CG . HIS A 1 370 ? 30.774 -24.198 -28.293 1.00 16.21 ? 439 HIS A CG 1 ATOM 2838 N ND1 . HIS A 1 370 ? 30.558 -23.530 -29.482 1.00 19.40 ? 439 HIS A ND1 1 ATOM 2839 C CD2 . HIS A 1 370 ? 29.603 -24.143 -27.618 1.00 17.16 ? 439 HIS A CD2 1 ATOM 2840 C CE1 . HIS A 1 370 ? 29.314 -23.087 -29.520 1.00 17.61 ? 439 HIS A CE1 1 ATOM 2841 N NE2 . HIS A 1 370 ? 28.711 -23.455 -28.404 1.00 18.09 ? 439 HIS A NE2 1 ATOM 2842 N N . SER A 1 371 ? 31.469 -27.739 -29.824 1.00 16.86 ? 440 SER A N 1 ATOM 2843 C CA . SER A 1 371 ? 31.570 -28.271 -31.179 1.00 16.32 ? 440 SER A CA 1 ATOM 2844 C C . SER A 1 371 ? 30.171 -28.543 -31.760 1.00 16.26 ? 440 SER A C 1 ATOM 2845 O O . SER A 1 371 ? 29.184 -27.989 -31.283 1.00 16.58 ? 440 SER A O 1 ATOM 2846 C CB . SER A 1 371 ? 32.461 -29.522 -31.193 1.00 16.99 ? 440 SER A CB 1 ATOM 2847 O OG . SER A 1 371 ? 32.920 -29.809 -32.534 1.00 15.82 ? 440 SER A OG 1 ATOM 2848 N N . ALA A 1 372 ? 30.081 -29.342 -32.820 1.00 15.95 ? 441 ALA A N 1 ATOM 2849 C CA . ALA A 1 372 ? 28.806 -29.503 -33.520 1.00 15.28 ? 441 ALA A CA 1 ATOM 2850 C C . ALA A 1 372 ? 28.724 -30.864 -34.139 1.00 14.28 ? 441 ALA A C 1 ATOM 2851 O O . ALA A 1 372 ? 29.755 -31.435 -34.422 1.00 15.70 ? 441 ALA A O 1 ATOM 2852 C CB . ALA A 1 372 ? 28.651 -28.394 -34.607 1.00 15.43 ? 441 ALA A CB 1 ATOM 2853 N N . ALA A 1 373 ? 27.511 -31.393 -34.305 1.00 13.27 ? 442 ALA A N 1 ATOM 2854 C CA . ALA A 1 373 ? 27.226 -32.422 -35.297 1.00 13.00 ? 442 ALA A CA 1 ATOM 2855 C C . ALA A 1 373 ? 26.783 -31.802 -36.672 1.00 13.30 ? 442 ALA A C 1 ATOM 2856 O O . ALA A 1 373 ? 26.599 -30.601 -36.761 1.00 12.69 ? 442 ALA A O 1 ATOM 2857 C CB . ALA A 1 373 ? 26.164 -33.299 -34.792 1.00 12.89 ? 442 ALA A CB 1 ATOM 2858 N N . THR A 1 374 ? 26.595 -32.636 -37.709 1.00 13.33 ? 443 THR A N 1 ATOM 2859 C CA . THR A 1 374 ? 25.944 -32.219 -38.965 1.00 14.27 ? 443 THR A CA 1 ATOM 2860 C C . THR A 1 374 ? 24.871 -33.213 -39.467 1.00 14.36 ? 443 THR A C 1 ATOM 2861 O O . THR A 1 374 ? 25.175 -34.373 -39.720 1.00 15.46 ? 443 THR A O 1 ATOM 2862 C CB . THR A 1 374 ? 26.957 -32.042 -40.087 1.00 14.19 ? 443 THR A CB 1 ATOM 2863 O OG1 . THR A 1 374 ? 28.070 -31.312 -39.597 1.00 16.07 ? 443 THR A OG1 1 ATOM 2864 C CG2 . THR A 1 374 ? 26.363 -31.273 -41.278 1.00 14.42 ? 443 THR A CG2 1 ATOM 2865 N N . ALA A 1 375 ? 23.635 -32.739 -39.644 1.00 14.57 ? 444 ALA A N 1 ATOM 2866 C CA . ALA A 1 375 ? 22.510 -33.556 -40.144 1.00 14.29 ? 444 ALA A CA 1 ATOM 2867 C C . ALA A 1 375 ? 22.233 -33.177 -41.596 1.00 14.69 ? 444 ALA A C 1 ATOM 2868 O O . ALA A 1 375 ? 22.170 -31.994 -41.918 1.00 14.06 ? 444 ALA A O 1 ATOM 2869 C CB . ALA A 1 375 ? 21.270 -33.309 -39.295 1.00 13.23 ? 444 ALA A CB 1 ATOM 2870 N N . ILE A 1 376 ? 22.093 -34.174 -42.469 1.00 15.96 ? 445 ILE A N 1 ATOM 2871 C CA . ILE A 1 376 ? 21.779 -33.938 -43.876 1.00 16.59 ? 445 ILE A CA 1 ATOM 2872 C C . ILE A 1 376 ? 20.399 -34.505 -44.230 1.00 17.63 ? 445 ILE A C 1 ATOM 2873 O O . ILE A 1 376 ? 20.009 -35.581 -43.755 1.00 17.04 ? 445 ILE A O 1 ATOM 2874 C CB . ILE A 1 376 ? 22.803 -34.566 -44.803 1.00 16.85 ? 445 ILE A CB 1 ATOM 2875 C CG1 . ILE A 1 376 ? 24.206 -33.985 -44.551 1.00 18.57 ? 445 ILE A CG1 1 ATOM 2876 C CG2 . ILE A 1 376 ? 22.381 -34.356 -46.260 1.00 16.20 ? 445 ILE A CG2 1 ATOM 2877 C CD1 . ILE A 1 376 ? 24.950 -34.539 -43.313 1.00 15.59 ? 445 ILE A CD1 1 ATOM 2878 N N . TYR A 1 377 ? 19.672 -33.727 -45.039 1.00 19.07 ? 446 TYR A N 1 ATOM 2879 C CA . TYR A 1 377 ? 18.400 -34.089 -45.654 1.00 19.51 ? 446 TYR A CA 1 ATOM 2880 C C . TYR A 1 377 ? 18.415 -33.712 -47.158 1.00 19.88 ? 446 TYR A C 1 ATOM 2881 O O . TYR A 1 377 ? 18.966 -32.678 -47.582 1.00 20.03 ? 446 TYR A O 1 ATOM 2882 C CB . TYR A 1 377 ? 17.276 -33.342 -44.951 1.00 19.79 ? 446 TYR A CB 1 ATOM 2883 C CG . TYR A 1 377 ? 16.885 -33.903 -43.591 1.00 19.04 ? 446 TYR A CG 1 ATOM 2884 C CD1 . TYR A 1 377 ? 15.670 -34.549 -43.412 1.00 19.35 ? 446 TYR A CD1 1 ATOM 2885 C CD2 . TYR A 1 377 ? 17.724 -33.776 -42.476 1.00 19.46 ? 446 TYR A CD2 1 ATOM 2886 C CE1 . TYR A 1 377 ? 15.292 -35.066 -42.154 1.00 18.39 ? 446 TYR A CE1 1 ATOM 2887 C CE2 . TYR A 1 377 ? 17.352 -34.307 -41.211 1.00 18.13 ? 446 TYR A CE2 1 ATOM 2888 C CZ . TYR A 1 377 ? 16.138 -34.950 -41.065 1.00 17.78 ? 446 TYR A CZ 1 ATOM 2889 O OH . TYR A 1 377 ? 15.754 -35.480 -39.829 1.00 17.13 ? 446 TYR A OH 1 ATOM 2890 N N . CYS A 1 378 ? 17.810 -34.550 -47.970 1.00 20.38 ? 447 CYS A N 1 ATOM 2891 C CA . CYS A 1 378 ? 17.853 -34.368 -49.418 1.00 20.74 ? 447 CYS A CA 1 ATOM 2892 C C . CYS A 1 378 ? 16.525 -34.783 -50.048 1.00 20.14 ? 447 CYS A C 1 ATOM 2893 O O . CYS A 1 378 ? 15.831 -35.645 -49.518 1.00 18.48 ? 447 CYS A O 1 ATOM 2894 C CB . CYS A 1 378 ? 18.978 -35.218 -50.024 1.00 21.13 ? 447 CYS A CB 1 ATOM 2895 S SG . CYS A 1 378 ? 20.643 -34.833 -49.445 1.00 25.53 ? 447 CYS A SG 1 ATOM 2896 N N . LEU A 1 379 ? 16.205 -34.154 -51.188 1.00 20.51 ? 448 LEU A N 1 ATOM 2897 C CA . LEU A 1 379 ? 15.081 -34.561 -52.053 1.00 20.53 ? 448 LEU A CA 1 ATOM 2898 C C . LEU A 1 379 ? 15.263 -36.033 -52.326 1.00 19.89 ? 448 LEU A C 1 ATOM 2899 O O . LEU A 1 379 ? 16.336 -36.429 -52.743 1.00 20.73 ? 448 LEU A O 1 ATOM 2900 C CB . LEU A 1 379 ? 15.076 -33.797 -53.403 1.00 20.17 ? 448 LEU A CB 1 ATOM 2901 C CG . LEU A 1 379 ? 13.796 -33.821 -54.264 1.00 19.83 ? 448 LEU A CG 1 ATOM 2902 C CD1 . LEU A 1 379 ? 12.730 -32.877 -53.733 1.00 18.14 ? 448 LEU A CD1 1 ATOM 2903 C CD2 . LEU A 1 379 ? 14.048 -33.525 -55.769 1.00 18.23 ? 448 LEU A CD2 1 ATOM 2904 N N . MET A 1 380 ? 14.252 -36.837 -52.022 1.00 19.52 ? 449 MET A N 1 ATOM 2905 C CA . MET A 1 380 ? 14.241 -38.250 -52.407 1.00 19.69 ? 449 MET A CA 1 ATOM 2906 C C . MET A 1 380 ? 12.822 -38.828 -52.346 1.00 18.75 ? 449 MET A C 1 ATOM 2907 O O . MET A 1 380 ? 12.099 -38.664 -51.355 1.00 18.74 ? 449 MET A O 1 ATOM 2908 C CB . MET A 1 380 ? 15.263 -39.083 -51.605 1.00 20.21 ? 449 MET A CB 1 ATOM 2909 C CG . MET A 1 380 ? 15.086 -39.118 -50.090 1.00 23.03 ? 449 MET A CG 1 ATOM 2910 S SD . MET A 1 380 ? 16.507 -39.929 -49.305 1.00 26.76 ? 449 MET A SD 1 ATOM 2911 C CE . MET A 1 380 ? 16.349 -41.545 -50.024 1.00 25.52 ? 449 MET A CE 1 ATOM 2912 N N . GLY A 1 381 ? 12.410 -39.462 -53.444 1.00 17.89 ? 450 GLY A N 1 ATOM 2913 C CA . GLY A 1 381 ? 11.040 -39.937 -53.604 1.00 17.53 ? 450 GLY A CA 1 ATOM 2914 C C . GLY A 1 381 ? 9.916 -38.921 -53.385 1.00 17.52 ? 450 GLY A C 1 ATOM 2915 O O . GLY A 1 381 ? 10.091 -37.688 -53.467 1.00 17.41 ? 450 GLY A O 1 ATOM 2916 N N . SER A 1 382 ? 8.746 -39.453 -53.073 1.00 17.52 ? 451 SER A N 1 ATOM 2917 C CA A SER A 1 382 ? 7.541 -38.664 -52.927 0.70 17.97 ? 451 SER A CA 1 ATOM 2918 C CA B SER A 1 382 ? 7.552 -38.629 -52.909 0.30 17.63 ? 451 SER A CA 1 ATOM 2919 C C . SER A 1 382 ? 6.935 -38.803 -51.511 1.00 17.98 ? 451 SER A C 1 ATOM 2920 O O . SER A 1 382 ? 7.475 -39.525 -50.667 1.00 18.18 ? 451 SER A O 1 ATOM 2921 C CB A SER A 1 382 ? 6.540 -39.099 -53.981 0.70 17.68 ? 451 SER A CB 1 ATOM 2922 C CB B SER A 1 382 ? 6.552 -38.977 -54.006 0.30 17.47 ? 451 SER A CB 1 ATOM 2923 O OG A SER A 1 382 ? 5.696 -38.011 -54.284 0.70 18.28 ? 451 SER A OG 1 ATOM 2924 O OG B SER A 1 382 ? 6.342 -40.376 -54.049 0.30 16.28 ? 451 SER A OG 1 ATOM 2925 N N . GLY A 1 383 ? 5.831 -38.106 -51.255 1.00 17.70 ? 452 GLY A N 1 ATOM 2926 C CA . GLY A 1 383 ? 5.161 -38.158 -49.942 1.00 18.56 ? 452 GLY A CA 1 ATOM 2927 C C . GLY A 1 383 ? 5.588 -37.096 -48.932 1.00 18.58 ? 452 GLY A C 1 ATOM 2928 O O . GLY A 1 383 ? 5.905 -35.992 -49.325 1.00 17.77 ? 452 GLY A O 1 ATOM 2929 N N . GLN A 1 384 ? 5.574 -37.427 -47.631 1.00 19.27 ? 453 GLN A N 1 ATOM 2930 C CA A GLN A 1 384 ? 6.051 -36.474 -46.628 0.50 19.61 ? 453 GLN A CA 1 ATOM 2931 C CA B GLN A 1 384 ? 6.016 -36.522 -46.542 0.50 19.53 ? 453 GLN A CA 1 ATOM 2932 C C . GLN A 1 384 ? 7.367 -36.883 -45.986 1.00 19.67 ? 453 GLN A C 1 ATOM 2933 O O . GLN A 1 384 ? 7.713 -38.063 -45.943 1.00 20.52 ? 453 GLN A O 1 ATOM 2934 C CB A GLN A 1 384 ? 4.979 -36.148 -45.568 0.50 20.01 ? 453 GLN A CB 1 ATOM 2935 C CB B GLN A 1 384 ? 5.085 -36.589 -45.331 0.50 19.74 ? 453 GLN A CB 1 ATOM 2936 C CG A GLN A 1 384 ? 4.641 -37.227 -44.540 0.50 20.57 ? 453 GLN A CG 1 ATOM 2937 C CG B GLN A 1 384 ? 3.833 -35.779 -45.455 0.50 20.49 ? 453 GLN A CG 1 ATOM 2938 C CD A GLN A 1 384 ? 3.490 -36.802 -43.603 0.50 21.58 ? 453 GLN A CD 1 ATOM 2939 C CD B GLN A 1 384 ? 2.748 -36.565 -46.098 0.50 19.22 ? 453 GLN A CD 1 ATOM 2940 O OE1 A GLN A 1 384 ? 3.475 -37.161 -42.420 0.50 22.82 ? 453 GLN A OE1 1 ATOM 2941 O OE1 B GLN A 1 384 ? 2.195 -37.486 -45.497 0.50 19.99 ? 453 GLN A OE1 1 ATOM 2942 N NE2 A GLN A 1 384 ? 2.528 -36.038 -44.135 0.50 19.91 ? 453 GLN A NE2 1 ATOM 2943 N NE2 B GLN A 1 384 ? 2.430 -36.219 -47.329 0.50 20.97 ? 453 GLN A NE2 1 ATOM 2944 N N . LEU A 1 385 ? 8.100 -35.866 -45.515 1.00 19.85 ? 454 LEU A N 1 ATOM 2945 C CA . LEU A 1 385 ? 9.285 -36.054 -44.700 1.00 20.07 ? 454 LEU A CA 1 ATOM 2946 C C . LEU A 1 385 ? 8.886 -36.824 -43.438 1.00 20.33 ? 454 LEU A C 1 ATOM 2947 O O . LEU A 1 385 ? 7.877 -36.513 -42.791 1.00 21.54 ? 454 LEU A O 1 ATOM 2948 C CB . LEU A 1 385 ? 9.911 -34.715 -44.335 1.00 19.68 ? 454 LEU A CB 1 ATOM 2949 C CG . LEU A 1 385 ? 11.231 -34.693 -43.557 1.00 19.58 ? 454 LEU A CG 1 ATOM 2950 C CD1 . LEU A 1 385 ? 11.958 -33.471 -43.995 1.00 19.13 ? 454 LEU A CD1 1 ATOM 2951 C CD2 . LEU A 1 385 ? 11.048 -34.675 -41.971 1.00 18.08 ? 454 LEU A CD2 1 ATOM 2952 N N . LEU A 1 386 ? 9.685 -37.827 -43.098 1.00 19.58 ? 455 LEU A N 1 ATOM 2953 C CA . LEU A 1 386 ? 9.256 -38.825 -42.144 1.00 19.60 ? 455 LEU A CA 1 ATOM 2954 C C . LEU A 1 386 ? 9.962 -38.852 -40.771 1.00 18.27 ? 455 LEU A C 1 ATOM 2955 O O . LEU A 1 386 ? 9.313 -39.115 -39.794 1.00 18.74 ? 455 LEU A O 1 ATOM 2956 C CB . LEU A 1 386 ? 9.353 -40.211 -42.792 1.00 19.23 ? 455 LEU A CB 1 ATOM 2957 C CG . LEU A 1 386 ? 8.112 -41.013 -43.184 1.00 20.53 ? 455 LEU A CG 1 ATOM 2958 C CD1 . LEU A 1 386 ? 6.775 -40.339 -42.810 1.00 21.28 ? 455 LEU A CD1 1 ATOM 2959 C CD2 . LEU A 1 386 ? 8.136 -41.447 -44.677 1.00 20.57 ? 455 LEU A CD2 1 ATOM 2960 N N . TRP A 1 387 ? 11.270 -38.648 -40.687 1.00 17.89 ? 456 TRP A N 1 ATOM 2961 C CA . TRP A 1 387 ? 11.952 -38.732 -39.356 1.00 17.55 ? 456 TRP A CA 1 ATOM 2962 C C . TRP A 1 387 ? 12.864 -37.553 -39.046 1.00 16.77 ? 456 TRP A C 1 ATOM 2963 O O . TRP A 1 387 ? 13.431 -36.887 -39.951 1.00 17.17 ? 456 TRP A O 1 ATOM 2964 C CB . TRP A 1 387 ? 12.724 -40.054 -39.207 1.00 17.34 ? 456 TRP A CB 1 ATOM 2965 C CG . TRP A 1 387 ? 12.381 -40.881 -37.983 1.00 18.57 ? 456 TRP A CG 1 ATOM 2966 C CD1 . TRP A 1 387 ? 11.285 -40.750 -37.164 1.00 19.13 ? 456 TRP A CD1 1 ATOM 2967 C CD2 . TRP A 1 387 ? 13.123 -42.004 -37.466 1.00 19.24 ? 456 TRP A CD2 1 ATOM 2968 N NE1 . TRP A 1 387 ? 11.299 -41.720 -36.181 1.00 18.88 ? 456 TRP A NE1 1 ATOM 2969 C CE2 . TRP A 1 387 ? 12.413 -42.501 -36.342 1.00 19.00 ? 456 TRP A CE2 1 ATOM 2970 C CE3 . TRP A 1 387 ? 14.314 -42.629 -37.836 1.00 19.17 ? 456 TRP A CE3 1 ATOM 2971 C CZ2 . TRP A 1 387 ? 12.860 -43.593 -35.593 1.00 20.38 ? 456 TRP A CZ2 1 ATOM 2972 C CZ3 . TRP A 1 387 ? 14.751 -43.719 -37.098 1.00 20.09 ? 456 TRP A CZ3 1 ATOM 2973 C CH2 . TRP A 1 387 ? 14.027 -44.186 -35.982 1.00 20.34 ? 456 TRP A CH2 1 ATOM 2974 N N . ASP A 1 388 ? 12.982 -37.302 -37.750 1.00 15.99 ? 457 ASP A N 1 ATOM 2975 C CA . ASP A 1 388 ? 13.807 -36.237 -37.225 1.00 15.73 ? 457 ASP A CA 1 ATOM 2976 C C . ASP A 1 388 ? 15.188 -36.764 -36.787 1.00 15.40 ? 457 ASP A C 1 ATOM 2977 O O . ASP A 1 388 ? 15.437 -37.999 -36.794 1.00 14.98 ? 457 ASP A O 1 ATOM 2978 C CB . ASP A 1 388 ? 13.084 -35.585 -36.061 1.00 16.39 ? 457 ASP A CB 1 ATOM 2979 C CG . ASP A 1 388 ? 12.950 -36.514 -34.867 1.00 18.30 ? 457 ASP A CG 1 ATOM 2980 O OD1 . ASP A 1 388 ? 12.327 -37.584 -35.009 1.00 20.75 ? 457 ASP A OD1 1 ATOM 2981 O OD2 . ASP A 1 388 ? 13.482 -36.179 -33.800 1.00 20.23 ? 457 ASP A OD2 1 ATOM 2982 N N . THR A 1 389 ? 16.074 -35.836 -36.409 1.00 14.54 ? 458 THR A N 1 ATOM 2983 C CA . THR A 1 389 ? 17.461 -36.161 -36.057 1.00 14.59 ? 458 THR A CA 1 ATOM 2984 C C . THR A 1 389 ? 17.896 -35.733 -34.646 1.00 14.59 ? 458 THR A C 1 ATOM 2985 O O . THR A 1 389 ? 17.650 -34.590 -34.210 1.00 14.77 ? 458 THR A O 1 ATOM 2986 C CB . THR A 1 389 ? 18.425 -35.532 -37.102 1.00 14.53 ? 458 THR A CB 1 ATOM 2987 O OG1 . THR A 1 389 ? 18.095 -36.033 -38.407 1.00 17.20 ? 458 THR A OG1 1 ATOM 2988 C CG2 . THR A 1 389 ? 19.812 -35.912 -36.829 1.00 14.86 ? 458 THR A CG2 1 ATOM 2989 N N . VAL A 1 390 ? 18.556 -36.649 -33.933 1.00 14.28 ? 459 VAL A N 1 ATOM 2990 C CA . VAL A 1 390 ? 19.158 -36.333 -32.636 1.00 13.53 ? 459 VAL A CA 1 ATOM 2991 C C . VAL A 1 390 ? 20.681 -36.522 -32.719 1.00 13.12 ? 459 VAL A C 1 ATOM 2992 O O . VAL A 1 390 ? 21.185 -37.385 -33.440 1.00 13.84 ? 459 VAL A O 1 ATOM 2993 C CB . VAL A 1 390 ? 18.532 -37.185 -31.448 1.00 13.08 ? 459 VAL A CB 1 ATOM 2994 C CG1 . VAL A 1 390 ? 17.044 -37.039 -31.425 1.00 13.45 ? 459 VAL A CG1 1 ATOM 2995 C CG2 . VAL A 1 390 ? 18.944 -38.657 -31.490 1.00 11.31 ? 459 VAL A CG2 1 ATOM 2996 N N . THR A 1 391 ? 21.429 -35.734 -31.977 1.00 12.52 ? 460 THR A N 1 ATOM 2997 C CA . THR A 1 391 ? 22.897 -35.902 -31.972 1.00 12.75 ? 460 THR A CA 1 ATOM 2998 C C . THR A 1 391 ? 23.323 -37.151 -31.207 1.00 12.55 ? 460 THR A C 1 ATOM 2999 O O . THR A 1 391 ? 24.325 -37.779 -31.532 1.00 13.27 ? 460 THR A O 1 ATOM 3000 C CB . THR A 1 391 ? 23.610 -34.700 -31.365 1.00 12.67 ? 460 THR A CB 1 ATOM 3001 O OG1 . THR A 1 391 ? 23.625 -34.815 -29.931 1.00 14.01 ? 460 THR A OG1 1 ATOM 3002 C CG2 . THR A 1 391 ? 22.930 -33.389 -31.786 1.00 12.41 ? 460 THR A CG2 1 ATOM 3003 N N . GLY A 1 392 ? 22.542 -37.508 -30.185 1.00 13.13 ? 461 GLY A N 1 ATOM 3004 C CA . GLY A 1 392 ? 22.884 -38.601 -29.274 1.00 12.72 ? 461 GLY A CA 1 ATOM 3005 C C . GLY A 1 392 ? 24.065 -38.378 -28.342 1.00 12.43 ? 461 GLY A C 1 ATOM 3006 O O . GLY A 1 392 ? 24.556 -39.346 -27.740 1.00 12.21 ? 461 GLY A O 1 ATOM 3007 N N . VAL A 1 393 ? 24.555 -37.149 -28.209 1.00 12.22 ? 462 VAL A N 1 ATOM 3008 C CA . VAL A 1 393 ? 25.734 -36.911 -27.351 1.00 13.00 ? 462 VAL A CA 1 ATOM 3009 C C . VAL A 1 393 ? 25.344 -36.523 -25.906 1.00 13.32 ? 462 VAL A C 1 ATOM 3010 O O . VAL A 1 393 ? 24.396 -35.780 -25.712 1.00 13.56 ? 462 VAL A O 1 ATOM 3011 C CB . VAL A 1 393 ? 26.627 -35.806 -27.931 1.00 13.00 ? 462 VAL A CB 1 ATOM 3012 C CG1 . VAL A 1 393 ? 27.808 -35.516 -26.987 1.00 12.46 ? 462 VAL A CG1 1 ATOM 3013 C CG2 . VAL A 1 393 ? 27.079 -36.180 -29.355 1.00 12.66 ? 462 VAL A CG2 1 ATOM 3014 N N . ASP A 1 394 ? 26.061 -37.044 -24.913 1.00 13.66 ? 463 ASP A N 1 ATOM 3015 C CA . ASP A 1 394 ? 25.979 -36.558 -23.510 1.00 13.81 ? 463 ASP A CA 1 ATOM 3016 C C . ASP A 1 394 ? 27.288 -35.792 -23.290 1.00 14.90 ? 463 ASP A C 1 ATOM 3017 O O . ASP A 1 394 ? 28.359 -36.402 -23.225 1.00 14.96 ? 463 ASP A O 1 ATOM 3018 C CB . ASP A 1 394 ? 25.832 -37.756 -22.548 1.00 13.45 ? 463 ASP A CB 1 ATOM 3019 C CG . ASP A 1 394 ? 25.874 -37.370 -21.035 1.00 15.08 ? 463 ASP A CG 1 ATOM 3020 O OD1 . ASP A 1 394 ? 25.574 -38.236 -20.187 1.00 16.24 ? 463 ASP A OD1 1 ATOM 3021 O OD2 . ASP A 1 394 ? 26.213 -36.240 -20.664 1.00 16.62 ? 463 ASP A OD2 1 ATOM 3022 N N . MET A 1 395 ? 27.221 -34.462 -23.190 1.00 15.82 ? 464 MET A N 1 ATOM 3023 C CA . MET A 1 395 ? 28.433 -33.625 -23.124 1.00 16.59 ? 464 MET A CA 1 ATOM 3024 C C . MET A 1 395 ? 29.354 -33.880 -21.911 1.00 17.45 ? 464 MET A C 1 ATOM 3025 O O . MET A 1 395 ? 30.466 -33.394 -21.883 1.00 17.43 ? 464 MET A O 1 ATOM 3026 C CB . MET A 1 395 ? 28.042 -32.125 -23.157 1.00 16.66 ? 464 MET A CB 1 ATOM 3027 C CG . MET A 1 395 ? 27.426 -31.665 -24.488 1.00 16.10 ? 464 MET A CG 1 ATOM 3028 S SD . MET A 1 395 ? 27.226 -29.902 -24.596 1.00 14.83 ? 464 MET A SD 1 ATOM 3029 C CE . MET A 1 395 ? 28.903 -29.333 -24.517 1.00 12.83 ? 464 MET A CE 1 ATOM 3030 N N . ALA A 1 396 ? 28.881 -34.597 -20.897 1.00 18.99 ? 465 ALA A N 1 ATOM 3031 C CA . ALA A 1 396 ? 29.682 -34.850 -19.687 1.00 19.85 ? 465 ALA A CA 1 ATOM 3032 C C . ALA A 1 396 ? 30.541 -36.114 -19.779 1.00 20.73 ? 465 ALA A C 1 ATOM 3033 O O . ALA A 1 396 ? 31.235 -36.465 -18.820 1.00 20.89 ? 465 ALA A O 1 ATOM 3034 C CB . ALA A 1 396 ? 28.773 -34.923 -18.466 1.00 19.52 ? 465 ALA A CB 1 ATOM 3035 N N . LEU A 1 397 ? 30.475 -36.809 -20.915 1.00 21.56 ? 466 LEU A N 1 ATOM 3036 C CA . LEU A 1 397 ? 31.193 -38.049 -21.071 1.00 22.74 ? 466 LEU A CA 1 ATOM 3037 C C . LEU A 1 397 ? 32.581 -37.735 -21.605 1.00 23.38 ? 466 LEU A C 1 ATOM 3038 O O . LEU A 1 397 ? 32.747 -36.760 -22.336 1.00 24.08 ? 466 LEU A O 1 ATOM 3039 C CB . LEU A 1 397 ? 30.427 -39.033 -21.968 1.00 22.55 ? 466 LEU A CB 1 ATOM 3040 C CG . LEU A 1 397 ? 29.134 -39.622 -21.385 1.00 23.26 ? 466 LEU A CG 1 ATOM 3041 C CD1 . LEU A 1 397 ? 28.604 -40.765 -22.253 1.00 23.43 ? 466 LEU A CD1 1 ATOM 3042 C CD2 . LEU A 1 397 ? 29.270 -40.092 -19.899 1.00 23.66 ? 466 LEU A CD2 1 ATOM 3043 O OXT . LEU A 1 397 ? 33.567 -38.409 -21.276 1.00 24.61 ? 466 LEU A OXT 1 ATOM 3044 N N . PRO B 1 9 ? 11.229 -5.197 19.112 1.00 36.53 ? 78 PRO B N 1 ATOM 3045 C CA . PRO B 1 9 ? 11.121 -6.647 19.248 1.00 36.26 ? 78 PRO B CA 1 ATOM 3046 C C . PRO B 1 9 ? 12.426 -7.248 19.728 1.00 35.47 ? 78 PRO B C 1 ATOM 3047 O O . PRO B 1 9 ? 13.291 -6.518 20.201 1.00 36.33 ? 78 PRO B O 1 ATOM 3048 C CB . PRO B 1 9 ? 10.785 -7.123 17.817 1.00 36.56 ? 78 PRO B CB 1 ATOM 3049 C CG . PRO B 1 9 ? 10.648 -5.867 16.966 1.00 37.06 ? 78 PRO B CG 1 ATOM 3050 C CD . PRO B 1 9 ? 10.519 -4.713 17.921 1.00 36.73 ? 78 PRO B CD 1 ATOM 3051 N N . GLU B 1 10 ? 12.563 -8.566 19.623 1.00 34.42 ? 79 GLU B N 1 ATOM 3052 C CA . GLU B 1 10 ? 13.799 -9.242 19.996 1.00 33.22 ? 79 GLU B CA 1 ATOM 3053 C C . GLU B 1 10 ? 14.582 -9.728 18.768 1.00 32.23 ? 79 GLU B C 1 ATOM 3054 O O . GLU B 1 10 ? 14.021 -9.921 17.681 1.00 31.89 ? 79 GLU B O 1 ATOM 3055 C CB . GLU B 1 10 ? 13.480 -10.402 20.940 1.00 33.38 ? 79 GLU B CB 1 ATOM 3056 C CG . GLU B 1 10 ? 14.692 -11.189 21.497 0.50 34.07 ? 79 GLU B CG 1 ATOM 3057 C CD . GLU B 1 10 ? 15.818 -10.325 22.060 0.50 34.54 ? 79 GLU B CD 1 ATOM 3058 O OE1 . GLU B 1 10 ? 16.928 -10.868 22.228 0.50 35.58 ? 79 GLU B OE1 1 ATOM 3059 O OE2 . GLU B 1 10 ? 15.617 -9.121 22.330 0.50 35.11 ? 79 GLU B OE2 1 ATOM 3060 N N . TRP B 1 11 ? 15.890 -9.888 18.956 1.00 30.84 ? 80 TRP B N 1 ATOM 3061 C CA . TRP B 1 11 ? 16.776 -10.466 17.958 1.00 29.54 ? 80 TRP B CA 1 ATOM 3062 C C . TRP B 1 11 ? 16.310 -11.862 17.541 1.00 28.82 ? 80 TRP B C 1 ATOM 3063 O O . TRP B 1 11 ? 15.898 -12.649 18.382 1.00 29.16 ? 80 TRP B O 1 ATOM 3064 C CB . TRP B 1 11 ? 18.181 -10.603 18.534 1.00 28.92 ? 80 TRP B CB 1 ATOM 3065 C CG . TRP B 1 11 ? 18.818 -9.341 18.993 1.00 28.64 ? 80 TRP B CG 1 ATOM 3066 C CD1 . TRP B 1 11 ? 19.337 -9.092 20.232 1.00 28.76 ? 80 TRP B CD1 1 ATOM 3067 C CD2 . TRP B 1 11 ? 19.063 -8.164 18.215 1.00 28.06 ? 80 TRP B CD2 1 ATOM 3068 N NE1 . TRP B 1 11 ? 19.869 -7.829 20.280 1.00 28.12 ? 80 TRP B NE1 1 ATOM 3069 C CE2 . TRP B 1 11 ? 19.721 -7.238 19.056 1.00 27.43 ? 80 TRP B CE2 1 ATOM 3070 C CE3 . TRP B 1 11 ? 18.794 -7.800 16.889 1.00 26.82 ? 80 TRP B CE3 1 ATOM 3071 C CZ2 . TRP B 1 11 ? 20.108 -5.980 18.617 1.00 26.60 ? 80 TRP B CZ2 1 ATOM 3072 C CZ3 . TRP B 1 11 ? 19.178 -6.553 16.461 1.00 26.84 ? 80 TRP B CZ3 1 ATOM 3073 C CH2 . TRP B 1 11 ? 19.820 -5.654 17.320 1.00 26.23 ? 80 TRP B CH2 1 ATOM 3074 N N . THR B 1 12 ? 16.392 -12.184 16.254 1.00 28.11 ? 81 THR B N 1 ATOM 3075 C CA A THR B 1 12 ? 16.067 -13.514 15.743 0.50 27.50 ? 81 THR B CA 1 ATOM 3076 C CA B THR B 1 12 ? 16.023 -13.520 15.847 0.50 27.75 ? 81 THR B CA 1 ATOM 3077 C C . THR B 1 12 ? 17.177 -14.484 16.126 1.00 27.31 ? 81 THR B C 1 ATOM 3078 O O . THR B 1 12 ? 18.326 -14.075 16.278 1.00 26.70 ? 81 THR B O 1 ATOM 3079 C CB A THR B 1 12 ? 15.907 -13.525 14.183 0.50 27.54 ? 81 THR B CB 1 ATOM 3080 C CB B THR B 1 12 ? 15.516 -13.571 14.394 0.50 27.81 ? 81 THR B CB 1 ATOM 3081 O OG1 A THR B 1 12 ? 15.075 -14.620 13.779 0.50 26.52 ? 81 THR B OG1 1 ATOM 3082 O OG1 B THR B 1 12 ? 16.472 -12.976 13.513 0.50 28.62 ? 81 THR B OG1 1 ATOM 3083 C CG2 A THR B 1 12 ? 17.267 -13.652 13.478 0.50 27.28 ? 81 THR B CG2 1 ATOM 3084 C CG2 B THR B 1 12 ? 14.209 -12.819 14.298 0.50 27.64 ? 81 THR B CG2 1 ATOM 3085 N N . TYR B 1 13 ? 16.815 -15.758 16.265 1.00 27.22 ? 82 TYR B N 1 ATOM 3086 C CA . TYR B 1 13 ? 17.720 -16.868 16.541 1.00 27.18 ? 82 TYR B CA 1 ATOM 3087 C C . TYR B 1 13 ? 17.182 -18.052 15.729 1.00 26.04 ? 82 TYR B C 1 ATOM 3088 O O . TYR B 1 13 ? 15.984 -18.190 15.588 1.00 25.01 ? 82 TYR B O 1 ATOM 3089 C CB . TYR B 1 13 ? 17.700 -17.223 18.050 1.00 27.90 ? 82 TYR B CB 1 ATOM 3090 C CG . TYR B 1 13 ? 18.205 -16.118 18.984 1.00 30.93 ? 82 TYR B CG 1 ATOM 3091 C CD1 . TYR B 1 13 ? 19.532 -16.097 19.416 1.00 33.73 ? 82 TYR B CD1 1 ATOM 3092 C CD2 . TYR B 1 13 ? 17.355 -15.106 19.438 1.00 33.81 ? 82 TYR B CD2 1 ATOM 3093 C CE1 . TYR B 1 13 ? 20.019 -15.084 20.272 1.00 35.36 ? 82 TYR B CE1 1 ATOM 3094 C CE2 . TYR B 1 13 ? 17.826 -14.078 20.289 1.00 35.63 ? 82 TYR B CE2 1 ATOM 3095 C CZ . TYR B 1 13 ? 19.168 -14.077 20.704 1.00 36.93 ? 82 TYR B CZ 1 ATOM 3096 O OH . TYR B 1 13 ? 19.659 -13.080 21.550 1.00 37.68 ? 82 TYR B OH 1 ATOM 3097 N N . PRO B 1 14 ? 18.055 -18.945 15.230 1.00 25.81 ? 83 PRO B N 1 ATOM 3098 C CA . PRO B 1 14 ? 17.503 -20.120 14.549 1.00 25.40 ? 83 PRO B CA 1 ATOM 3099 C C . PRO B 1 14 ? 16.756 -21.052 15.518 1.00 24.97 ? 83 PRO B C 1 ATOM 3100 O O . PRO B 1 14 ? 17.208 -21.244 16.655 1.00 25.08 ? 83 PRO B O 1 ATOM 3101 C CB . PRO B 1 14 ? 18.755 -20.812 14.009 1.00 25.27 ? 83 PRO B CB 1 ATOM 3102 C CG . PRO B 1 14 ? 19.817 -20.468 15.009 1.00 25.77 ? 83 PRO B CG 1 ATOM 3103 C CD . PRO B 1 14 ? 19.520 -19.045 15.391 1.00 25.67 ? 83 PRO B CD 1 ATOM 3104 N N . ARG B 1 15 ? 15.627 -21.606 15.086 1.00 24.20 ? 84 ARG B N 1 ATOM 3105 C CA . ARG B 1 15 ? 14.853 -22.558 15.898 1.00 23.74 ? 84 ARG B CA 1 ATOM 3106 C C . ARG B 1 15 ? 14.874 -23.924 15.282 1.00 22.76 ? 84 ARG B C 1 ATOM 3107 O O . ARG B 1 15 ? 15.294 -24.092 14.139 1.00 23.51 ? 84 ARG B O 1 ATOM 3108 C CB . ARG B 1 15 ? 13.370 -22.183 15.963 1.00 23.54 ? 84 ARG B CB 1 ATOM 3109 C CG . ARG B 1 15 ? 13.035 -20.855 16.549 1.00 24.43 ? 84 ARG B CG 1 ATOM 3110 C CD . ARG B 1 15 ? 12.080 -20.173 15.613 1.00 24.40 ? 84 ARG B CD 1 ATOM 3111 N NE . ARG B 1 15 ? 10.905 -19.682 16.272 1.00 26.14 ? 84 ARG B NE 1 ATOM 3112 C CZ . ARG B 1 15 ? 9.802 -19.287 15.646 1.00 26.37 ? 84 ARG B CZ 1 ATOM 3113 N NH1 . ARG B 1 15 ? 9.700 -19.293 14.303 1.00 27.36 ? 84 ARG B NH1 1 ATOM 3114 N NH2 . ARG B 1 15 ? 8.800 -18.861 16.381 1.00 25.79 ? 84 ARG B NH2 1 ATOM 3115 N N . LEU B 1 16 ? 14.339 -24.893 16.017 1.00 21.77 ? 85 LEU B N 1 ATOM 3116 C CA . LEU B 1 16 ? 14.066 -26.216 15.455 1.00 21.52 ? 85 LEU B CA 1 ATOM 3117 C C . LEU B 1 16 ? 13.102 -26.076 14.267 1.00 21.51 ? 85 LEU B C 1 ATOM 3118 O O . LEU B 1 16 ? 12.323 -25.110 14.189 1.00 21.71 ? 85 LEU B O 1 ATOM 3119 C CB . LEU B 1 16 ? 13.482 -27.147 16.524 1.00 20.81 ? 85 LEU B CB 1 ATOM 3120 C CG . LEU B 1 16 ? 14.454 -28.197 17.088 1.00 20.42 ? 85 LEU B CG 1 ATOM 3121 C CD1 . LEU B 1 16 ? 15.847 -27.651 17.428 1.00 17.61 ? 85 LEU B CD1 1 ATOM 3122 C CD2 . LEU B 1 16 ? 13.828 -28.934 18.286 1.00 18.84 ? 85 LEU B CD2 1 ATOM 3123 N N . SER B 1 17 ? 13.158 -27.014 13.339 1.00 21.39 ? 86 SER B N 1 ATOM 3124 C CA . SER B 1 17 ? 12.326 -26.902 12.147 1.00 21.87 ? 86 SER B CA 1 ATOM 3125 C C . SER B 1 17 ? 10.960 -27.501 12.370 1.00 22.30 ? 86 SER B C 1 ATOM 3126 O O . SER B 1 17 ? 10.782 -28.426 13.171 1.00 22.74 ? 86 SER B O 1 ATOM 3127 C CB . SER B 1 17 ? 12.988 -27.539 10.926 1.00 21.82 ? 86 SER B CB 1 ATOM 3128 O OG . SER B 1 17 ? 14.181 -26.863 10.634 1.00 22.11 ? 86 SER B OG 1 ATOM 3129 N N . CYS B 1 18 ? 9.989 -26.956 11.648 1.00 22.76 ? 87 CYS B N 1 ATOM 3130 C CA . CYS B 1 18 ? 8.645 -27.490 11.643 1.00 23.32 ? 87 CYS B CA 1 ATOM 3131 C C . CYS B 1 18 ? 8.685 -28.948 11.219 1.00 23.36 ? 87 CYS B C 1 ATOM 3132 O O . CYS B 1 18 ? 9.605 -29.358 10.499 1.00 23.96 ? 87 CYS B O 1 ATOM 3133 C CB . CYS B 1 18 ? 7.754 -26.655 10.712 1.00 23.16 ? 87 CYS B CB 1 ATOM 3134 S SG . CYS B 1 18 ? 7.743 -24.901 11.170 1.00 24.82 ? 87 CYS B SG 1 ATOM 3135 N N . PRO B 1 19 ? 7.707 -29.745 11.682 1.00 23.48 ? 88 PRO B N 1 ATOM 3136 C CA . PRO B 1 19 ? 7.741 -31.157 11.347 1.00 23.23 ? 88 PRO B CA 1 ATOM 3137 C C . PRO B 1 19 ? 7.375 -31.397 9.877 1.00 23.06 ? 88 PRO B C 1 ATOM 3138 O O . PRO B 1 19 ? 6.565 -30.665 9.296 1.00 22.98 ? 88 PRO B O 1 ATOM 3139 C CB . PRO B 1 19 ? 6.726 -31.782 12.310 1.00 23.30 ? 88 PRO B CB 1 ATOM 3140 C CG . PRO B 1 19 ? 5.885 -30.659 12.832 1.00 23.43 ? 88 PRO B CG 1 ATOM 3141 C CD . PRO B 1 19 ? 6.454 -29.357 12.359 1.00 23.81 ? 88 PRO B CD 1 ATOM 3142 N N . GLY B 1 20 ? 8.016 -32.394 9.274 1.00 22.73 ? 89 GLY B N 1 ATOM 3143 C CA . GLY B 1 20 ? 7.799 -32.698 7.865 1.00 22.13 ? 89 GLY B CA 1 ATOM 3144 C C . GLY B 1 20 ? 8.889 -33.614 7.401 1.00 21.24 ? 89 GLY B C 1 ATOM 3145 O O . GLY B 1 20 ? 9.866 -33.766 8.081 1.00 20.85 ? 89 GLY B O 1 ATOM 3146 N N . SER B 1 21 ? 8.727 -34.223 6.235 1.00 21.47 ? 90 SER B N 1 ATOM 3147 C CA . SER B 1 21 ? 9.787 -35.080 5.697 1.00 21.30 ? 90 SER B CA 1 ATOM 3148 C C . SER B 1 21 ? 9.932 -35.090 4.179 1.00 20.98 ? 90 SER B C 1 ATOM 3149 O O . SER B 1 21 ? 10.751 -35.847 3.669 1.00 21.03 ? 90 SER B O 1 ATOM 3150 C CB . SER B 1 21 ? 9.607 -36.513 6.198 1.00 21.10 ? 90 SER B CB 1 ATOM 3151 O OG . SER B 1 21 ? 8.285 -36.943 5.940 1.00 21.35 ? 90 SER B OG 1 ATOM 3152 N N . THR B 1 22 ? 9.151 -34.285 3.460 1.00 21.13 ? 91 THR B N 1 ATOM 3153 C CA . THR B 1 22 ? 9.437 -33.995 2.046 1.00 21.02 ? 91 THR B CA 1 ATOM 3154 C C . THR B 1 22 ? 9.154 -32.545 1.700 1.00 20.38 ? 91 THR B C 1 ATOM 3155 O O . THR B 1 22 ? 8.472 -31.846 2.442 1.00 20.01 ? 91 THR B O 1 ATOM 3156 C CB . THR B 1 22 ? 8.634 -34.871 1.080 1.00 21.31 ? 91 THR B CB 1 ATOM 3157 O OG1 . THR B 1 22 ? 9.236 -34.809 -0.221 1.00 23.29 ? 91 THR B OG1 1 ATOM 3158 C CG2 . THR B 1 22 ? 7.182 -34.415 0.978 1.00 21.12 ? 91 THR B CG2 1 ATOM 3159 N N . PHE B 1 23 ? 9.697 -32.118 0.559 1.00 19.85 ? 92 PHE B N 1 ATOM 3160 C CA . PHE B 1 23 ? 9.410 -30.804 -0.040 1.00 18.98 ? 92 PHE B CA 1 ATOM 3161 C C . PHE B 1 23 ? 8.351 -31.006 -1.101 1.00 18.29 ? 92 PHE B C 1 ATOM 3162 O O . PHE B 1 23 ? 8.253 -32.097 -1.677 1.00 17.89 ? 92 PHE B O 1 ATOM 3163 C CB . PHE B 1 23 ? 10.646 -30.208 -0.715 1.00 18.99 ? 92 PHE B CB 1 ATOM 3164 C CG . PHE B 1 23 ? 11.604 -29.534 0.222 1.00 18.86 ? 92 PHE B CG 1 ATOM 3165 C CD1 . PHE B 1 23 ? 11.932 -30.094 1.448 1.00 19.30 ? 92 PHE B CD1 1 ATOM 3166 C CD2 . PHE B 1 23 ? 12.215 -28.345 -0.140 1.00 17.94 ? 92 PHE B CD2 1 ATOM 3167 C CE1 . PHE B 1 23 ? 12.823 -29.457 2.301 1.00 18.01 ? 92 PHE B CE1 1 ATOM 3168 C CE2 . PHE B 1 23 ? 13.114 -27.719 0.725 1.00 18.44 ? 92 PHE B CE2 1 ATOM 3169 C CZ . PHE B 1 23 ? 13.406 -28.275 1.934 1.00 17.42 ? 92 PHE B CZ 1 ATOM 3170 N N . GLN B 1 24 ? 7.563 -29.947 -1.325 1.00 18.13 ? 93 GLN B N 1 ATOM 3171 C CA . GLN B 1 24 ? 6.548 -29.859 -2.370 1.00 17.44 ? 93 GLN B CA 1 ATOM 3172 C C . GLN B 1 24 ? 6.634 -28.478 -3.034 1.00 17.63 ? 93 GLN B C 1 ATOM 3173 O O . GLN B 1 24 ? 7.152 -27.523 -2.431 1.00 17.38 ? 93 GLN B O 1 ATOM 3174 C CB . GLN B 1 24 ? 5.152 -30.055 -1.781 1.00 17.47 ? 93 GLN B CB 1 ATOM 3175 C CG . GLN B 1 24 ? 4.956 -31.320 -0.931 1.00 17.77 ? 93 GLN B CG 1 ATOM 3176 C CD . GLN B 1 24 ? 4.884 -32.584 -1.779 1.00 20.70 ? 93 GLN B CD 1 ATOM 3177 O OE1 . GLN B 1 24 ? 4.967 -32.509 -3.022 1.00 19.26 ? 93 GLN B OE1 1 ATOM 3178 N NE2 . GLN B 1 24 ? 4.700 -33.758 -1.116 1.00 15.94 ? 93 GLN B NE2 1 ATOM 3179 N N . LYS B 1 25 ? 6.158 -28.401 -4.286 1.00 16.92 ? 94 LYS B N 1 ATOM 3180 C CA . LYS B 1 25 ? 6.009 -27.142 -5.015 1.00 16.41 ? 94 LYS B CA 1 ATOM 3181 C C . LYS B 1 25 ? 5.080 -26.218 -4.258 1.00 15.63 ? 94 LYS B C 1 ATOM 3182 O O . LYS B 1 25 ? 3.997 -26.620 -3.859 1.00 15.49 ? 94 LYS B O 1 ATOM 3183 C CB . LYS B 1 25 ? 5.460 -27.396 -6.434 1.00 16.83 ? 94 LYS B CB 1 ATOM 3184 C CG . LYS B 1 25 ? 5.299 -26.145 -7.352 1.00 16.33 ? 94 LYS B CG 1 ATOM 3185 C CD . LYS B 1 25 ? 4.604 -26.572 -8.624 1.00 15.92 ? 94 LYS B CD 1 ATOM 3186 C CE . LYS B 1 25 ? 4.594 -25.524 -9.720 1.00 18.09 ? 94 LYS B CE 1 ATOM 3187 N NZ . LYS B 1 25 ? 3.994 -26.084 -10.986 1.00 15.61 ? 94 LYS B NZ 1 ATOM 3188 N N . ALA B 1 26 ? 5.512 -24.974 -4.067 1.00 15.38 ? 95 ALA B N 1 ATOM 3189 C CA . ALA B 1 26 ? 4.814 -24.033 -3.187 1.00 15.17 ? 95 ALA B CA 1 ATOM 3190 C C . ALA B 1 26 ? 4.239 -22.861 -3.971 1.00 15.19 ? 95 ALA B C 1 ATOM 3191 O O . ALA B 1 26 ? 3.036 -22.575 -3.881 1.00 15.34 ? 95 ALA B O 1 ATOM 3192 C CB . ALA B 1 26 ? 5.762 -23.532 -2.098 1.00 15.13 ? 95 ALA B CB 1 ATOM 3193 N N . LEU B 1 27 ? 5.106 -22.220 -4.762 1.00 14.86 ? 96 LEU B N 1 ATOM 3194 C CA . LEU B 1 27 ? 4.845 -20.933 -5.401 1.00 13.95 ? 96 LEU B CA 1 ATOM 3195 C C . LEU B 1 27 ? 5.751 -20.733 -6.656 1.00 13.37 ? 96 LEU B C 1 ATOM 3196 O O . LEU B 1 27 ? 6.953 -21.034 -6.624 1.00 12.16 ? 96 LEU B O 1 ATOM 3197 C CB . LEU B 1 27 ? 5.146 -19.852 -4.393 1.00 13.75 ? 96 LEU B CB 1 ATOM 3198 C CG . LEU B 1 27 ? 5.085 -18.376 -4.749 1.00 15.07 ? 96 LEU B CG 1 ATOM 3199 C CD1 . LEU B 1 27 ? 3.806 -18.070 -5.534 1.00 15.02 ? 96 LEU B CD1 1 ATOM 3200 C CD2 . LEU B 1 27 ? 5.151 -17.552 -3.456 1.00 13.04 ? 96 LEU B CD2 1 ATOM 3201 N N . LEU B 1 28 ? 5.169 -20.233 -7.736 1.00 12.24 ? 97 LEU B N 1 ATOM 3202 C CA . LEU B 1 28 ? 5.951 -19.723 -8.861 1.00 13.19 ? 97 LEU B CA 1 ATOM 3203 C C . LEU B 1 28 ? 5.734 -18.206 -9.061 1.00 13.36 ? 97 LEU B C 1 ATOM 3204 O O . LEU B 1 28 ? 4.605 -17.712 -8.996 1.00 14.45 ? 97 LEU B O 1 ATOM 3205 C CB . LEU B 1 28 ? 5.600 -20.456 -10.141 1.00 12.39 ? 97 LEU B CB 1 ATOM 3206 C CG . LEU B 1 28 ? 6.163 -19.839 -11.447 1.00 13.36 ? 97 LEU B CG 1 ATOM 3207 C CD1 . LEU B 1 28 ? 7.694 -20.037 -11.587 1.00 10.27 ? 97 LEU B CD1 1 ATOM 3208 C CD2 . LEU B 1 28 ? 5.431 -20.354 -12.637 1.00 8.59 ? 97 LEU B CD2 1 ATOM 3209 N N . ILE B 1 29 ? 6.830 -17.484 -9.277 1.00 12.94 ? 98 ILE B N 1 ATOM 3210 C CA . ILE B 1 29 ? 6.819 -16.064 -9.626 1.00 12.48 ? 98 ILE B CA 1 ATOM 3211 C C . ILE B 1 29 ? 7.438 -15.989 -11.043 1.00 12.96 ? 98 ILE B C 1 ATOM 3212 O O . ILE B 1 29 ? 8.654 -16.066 -11.190 1.00 13.12 ? 98 ILE B O 1 ATOM 3213 C CB . ILE B 1 29 ? 7.637 -15.277 -8.607 1.00 12.14 ? 98 ILE B CB 1 ATOM 3214 C CG1 . ILE B 1 29 ? 7.151 -15.590 -7.176 1.00 11.01 ? 98 ILE B CG1 1 ATOM 3215 C CG2 . ILE B 1 29 ? 7.589 -13.778 -8.896 1.00 12.07 ? 98 ILE B CG2 1 ATOM 3216 C CD1 . ILE B 1 29 ? 5.929 -14.812 -6.780 1.00 10.78 ? 98 ILE B CD1 1 ATOM 3217 N N . SER B 1 30 ? 6.597 -15.939 -12.076 1.00 13.03 ? 99 SER B N 1 ATOM 3218 C CA . SER B 1 30 ? 7.045 -15.811 -13.468 1.00 13.39 ? 99 SER B CA 1 ATOM 3219 C C . SER B 1 30 ? 6.522 -14.478 -14.048 1.00 13.64 ? 99 SER B C 1 ATOM 3220 O O . SER B 1 30 ? 5.449 -14.421 -14.705 1.00 12.06 ? 99 SER B O 1 ATOM 3221 C CB . SER B 1 30 ? 6.548 -16.981 -14.302 1.00 13.82 ? 99 SER B CB 1 ATOM 3222 O OG . SER B 1 30 ? 7.053 -16.925 -15.628 1.00 14.68 ? 99 SER B OG 1 ATOM 3223 N N . PRO B 1 31 ? 7.270 -13.388 -13.783 1.00 13.35 ? 100 PRO B N 1 ATOM 3224 C CA . PRO B 1 31 ? 6.798 -12.063 -14.149 1.00 13.79 ? 100 PRO B CA 1 ATOM 3225 C C . PRO B 1 31 ? 6.630 -11.869 -15.655 1.00 13.26 ? 100 PRO B C 1 ATOM 3226 O O . PRO B 1 31 ? 5.863 -11.004 -16.078 1.00 13.33 ? 100 PRO B O 1 ATOM 3227 C CB . PRO B 1 31 ? 7.843 -11.119 -13.553 1.00 13.48 ? 100 PRO B CB 1 ATOM 3228 C CG . PRO B 1 31 ? 9.004 -11.929 -13.232 1.00 13.49 ? 100 PRO B CG 1 ATOM 3229 C CD . PRO B 1 31 ? 8.598 -13.354 -13.154 1.00 13.67 ? 100 PRO B CD 1 ATOM 3230 N N . HIS B 1 32 ? 7.270 -12.713 -16.449 1.00 13.32 ? 101 HIS B N 1 ATOM 3231 C CA . HIS B 1 32 ? 7.298 -12.509 -17.889 1.00 13.13 ? 101 HIS B CA 1 ATOM 3232 C C . HIS B 1 32 ? 6.180 -13.193 -18.612 1.00 13.22 ? 101 HIS B C 1 ATOM 3233 O O . HIS B 1 32 ? 6.011 -13.018 -19.851 1.00 11.83 ? 101 HIS B O 1 ATOM 3234 C CB . HIS B 1 32 ? 8.667 -12.881 -18.429 1.00 12.94 ? 101 HIS B CB 1 ATOM 3235 C CG . HIS B 1 32 ? 9.746 -12.003 -17.890 1.00 14.16 ? 101 HIS B CG 1 ATOM 3236 N ND1 . HIS B 1 32 ? 9.992 -10.745 -18.387 1.00 15.41 ? 101 HIS B ND1 1 ATOM 3237 C CD2 . HIS B 1 32 ? 10.610 -12.179 -16.861 1.00 17.89 ? 101 HIS B CD2 1 ATOM 3238 C CE1 . HIS B 1 32 ? 10.993 -10.201 -17.714 1.00 17.62 ? 101 HIS B CE1 1 ATOM 3239 N NE2 . HIS B 1 32 ? 11.377 -11.046 -16.772 1.00 16.06 ? 101 HIS B NE2 1 ATOM 3240 N N . ARG B 1 33 ? 5.403 -13.961 -17.849 1.00 12.49 ? 102 ARG B N 1 ATOM 3241 C CA . ARG B 1 33 ? 4.053 -14.311 -18.286 1.00 13.84 ? 102 ARG B CA 1 ATOM 3242 C C . ARG B 1 33 ? 3.206 -13.090 -18.702 1.00 14.01 ? 102 ARG B C 1 ATOM 3243 O O . ARG B 1 33 ? 2.208 -13.210 -19.443 1.00 13.93 ? 102 ARG B O 1 ATOM 3244 C CB . ARG B 1 33 ? 3.326 -15.097 -17.214 1.00 13.90 ? 102 ARG B CB 1 ATOM 3245 C CG . ARG B 1 33 ? 3.837 -16.519 -17.089 1.00 15.42 ? 102 ARG B CG 1 ATOM 3246 C CD . ARG B 1 33 ? 3.334 -17.362 -18.233 1.00 16.92 ? 102 ARG B CD 1 ATOM 3247 N NE . ARG B 1 33 ? 1.910 -17.660 -18.088 1.00 16.68 ? 102 ARG B NE 1 ATOM 3248 C CZ . ARG B 1 33 ? 1.213 -18.416 -18.923 1.00 17.56 ? 102 ARG B CZ 1 ATOM 3249 N NH1 . ARG B 1 33 ? 1.804 -18.949 -19.996 1.00 16.95 ? 102 ARG B NH1 1 ATOM 3250 N NH2 . ARG B 1 33 ? -0.081 -18.632 -18.691 1.00 18.39 ? 102 ARG B NH2 1 ATOM 3251 N N . PHE B 1 34 ? 3.605 -11.915 -18.235 1.00 14.02 ? 103 PHE B N 1 ATOM 3252 C CA . PHE B 1 34 ? 2.886 -10.685 -18.542 1.00 14.23 ? 103 PHE B CA 1 ATOM 3253 C C . PHE B 1 34 ? 3.666 -9.678 -19.414 1.00 14.11 ? 103 PHE B C 1 ATOM 3254 O O . PHE B 1 34 ? 3.164 -8.606 -19.713 1.00 13.40 ? 103 PHE B O 1 ATOM 3255 C CB . PHE B 1 34 ? 2.475 -10.062 -17.205 1.00 14.38 ? 103 PHE B CB 1 ATOM 3256 C CG . PHE B 1 34 ? 1.849 -11.045 -16.258 1.00 13.72 ? 103 PHE B CG 1 ATOM 3257 C CD1 . PHE B 1 34 ? 0.659 -11.689 -16.605 1.00 12.62 ? 103 PHE B CD1 1 ATOM 3258 C CD2 . PHE B 1 34 ? 2.438 -11.317 -15.005 1.00 14.38 ? 103 PHE B CD2 1 ATOM 3259 C CE1 . PHE B 1 34 ? 0.043 -12.598 -15.734 1.00 12.41 ? 103 PHE B CE1 1 ATOM 3260 C CE2 . PHE B 1 34 ? 1.845 -12.235 -14.113 1.00 13.74 ? 103 PHE B CE2 1 ATOM 3261 C CZ . PHE B 1 34 ? 0.629 -12.877 -14.477 1.00 13.13 ? 103 PHE B CZ 1 ATOM 3262 N N . GLY B 1 35 ? 4.854 -10.041 -19.892 1.00 15.27 ? 104 GLY B N 1 ATOM 3263 C CA . GLY B 1 35 ? 5.649 -9.134 -20.733 1.00 16.10 ? 104 GLY B CA 1 ATOM 3264 C C . GLY B 1 35 ? 5.380 -9.146 -22.241 1.00 17.39 ? 104 GLY B C 1 ATOM 3265 O O . GLY B 1 35 ? 6.302 -8.817 -23.019 1.00 18.62 ? 104 GLY B O 1 ATOM 3266 N N . GLU B 1 36 ? 4.176 -9.530 -22.699 1.00 17.47 ? 105 GLU B N 1 ATOM 3267 C CA . GLU B 1 36 ? 3.975 -9.636 -24.162 1.00 17.93 ? 105 GLU B CA 1 ATOM 3268 C C . GLU B 1 36 ? 3.882 -8.233 -24.737 1.00 18.44 ? 105 GLU B C 1 ATOM 3269 O O . GLU B 1 36 ? 3.510 -7.276 -24.043 1.00 17.24 ? 105 GLU B O 1 ATOM 3270 C CB . GLU B 1 36 ? 2.711 -10.415 -24.621 1.00 17.05 ? 105 GLU B CB 1 ATOM 3271 C CG . GLU B 1 36 ? 2.424 -11.746 -23.937 1.00 18.19 ? 105 GLU B CG 1 ATOM 3272 C CD . GLU B 1 36 ? 1.677 -11.552 -22.594 1.00 19.05 ? 105 GLU B CD 1 ATOM 3273 O OE1 . GLU B 1 36 ? 0.690 -12.275 -22.318 1.00 15.68 ? 105 GLU B OE1 1 ATOM 3274 O OE2 . GLU B 1 36 ? 2.078 -10.620 -21.857 1.00 16.87 ? 105 GLU B OE2 1 ATOM 3275 N N . THR B 1 37 ? 4.178 -8.163 -26.030 1.00 19.26 ? 106 THR B N 1 ATOM 3276 C CA . THR B 1 37 ? 4.003 -6.956 -26.840 1.00 20.01 ? 106 THR B CA 1 ATOM 3277 C C . THR B 1 37 ? 2.516 -6.593 -26.896 1.00 19.94 ? 106 THR B C 1 ATOM 3278 O O . THR B 1 37 ? 2.163 -5.418 -26.911 1.00 20.23 ? 106 THR B O 1 ATOM 3279 C CB . THR B 1 37 ? 4.640 -7.190 -28.243 1.00 19.97 ? 106 THR B CB 1 ATOM 3280 O OG1 . THR B 1 37 ? 6.044 -7.299 -28.065 1.00 19.88 ? 106 THR B OG1 1 ATOM 3281 C CG2 . THR B 1 37 ? 4.381 -6.046 -29.244 1.00 22.07 ? 106 THR B CG2 1 ATOM 3282 N N . LYS B 1 38 ? 1.666 -7.624 -26.880 1.00 20.34 ? 107 LYS B N 1 ATOM 3283 C CA A LYS B 1 38 ? 0.235 -7.385 -26.942 0.50 20.18 ? 107 LYS B CA 1 ATOM 3284 C CA B LYS B 1 38 ? 0.204 -7.533 -26.907 0.50 20.24 ? 107 LYS B CA 1 ATOM 3285 C C . LYS B 1 38 ? -0.381 -7.154 -25.547 1.00 20.14 ? 107 LYS B C 1 ATOM 3286 O O . LYS B 1 38 ? -1.553 -6.814 -25.444 1.00 20.21 ? 107 LYS B O 1 ATOM 3287 C CB A LYS B 1 38 ? -0.450 -8.504 -27.723 0.50 20.28 ? 107 LYS B CB 1 ATOM 3288 C CB B LYS B 1 38 ? -0.396 -8.896 -27.298 0.50 20.31 ? 107 LYS B CB 1 ATOM 3289 C CG A LYS B 1 38 ? 0.043 -8.606 -29.208 0.50 21.15 ? 107 LYS B CG 1 ATOM 3290 C CG B LYS B 1 38 ? -0.294 -9.253 -28.778 0.50 21.72 ? 107 LYS B CG 1 ATOM 3291 C CD A LYS B 1 38 ? 0.006 -7.258 -29.951 0.50 20.58 ? 107 LYS B CD 1 ATOM 3292 C CD B LYS B 1 38 ? -0.983 -10.571 -29.101 0.50 21.91 ? 107 LYS B CD 1 ATOM 3293 C CE A LYS B 1 38 ? -1.404 -6.942 -30.460 0.50 21.07 ? 107 LYS B CE 1 ATOM 3294 C CE B LYS B 1 38 ? -0.001 -11.647 -29.506 0.50 22.43 ? 107 LYS B CE 1 ATOM 3295 N NZ A LYS B 1 38 ? -1.786 -5.493 -30.362 0.50 20.61 ? 107 LYS B NZ 1 ATOM 3296 N NZ B LYS B 1 38 ? -0.673 -12.689 -30.357 0.50 24.04 ? 107 LYS B NZ 1 ATOM 3297 N N . GLY B 1 39 ? 0.418 -7.286 -24.489 1.00 20.09 ? 108 GLY B N 1 ATOM 3298 C CA . GLY B 1 39 ? -0.021 -7.003 -23.105 1.00 20.09 ? 108 GLY B CA 1 ATOM 3299 C C . GLY B 1 39 ? 0.148 -5.547 -22.677 1.00 20.18 ? 108 GLY B C 1 ATOM 3300 O O . GLY B 1 39 ? 0.484 -4.675 -23.489 1.00 19.44 ? 108 GLY B O 1 ATOM 3301 N N . ASN B 1 40 ? -0.088 -5.291 -21.382 1.00 19.77 ? 109 ASN B N 1 ATOM 3302 C CA . ASN B 1 40 ? -0.026 -3.951 -20.813 1.00 18.77 ? 109 ASN B CA 1 ATOM 3303 C C . ASN B 1 40 ? 0.717 -3.950 -19.452 1.00 19.43 ? 109 ASN B C 1 ATOM 3304 O O . ASN B 1 40 ? 0.395 -3.158 -18.585 1.00 18.73 ? 109 ASN B O 1 ATOM 3305 C CB . ASN B 1 40 ? -1.453 -3.417 -20.582 1.00 18.93 ? 109 ASN B CB 1 ATOM 3306 C CG . ASN B 1 40 ? -2.140 -2.910 -21.852 1.00 17.98 ? 109 ASN B CG 1 ATOM 3307 O OD1 . ASN B 1 40 ? -1.603 -2.074 -22.566 1.00 17.94 ? 109 ASN B OD1 1 ATOM 3308 N ND2 . ASN B 1 40 ? -3.373 -3.359 -22.085 1.00 17.07 ? 109 ASN B ND2 1 ATOM 3309 N N . SER B 1 41 ? 1.683 -4.845 -19.243 1.00 19.76 ? 110 SER B N 1 ATOM 3310 C CA . SER B 1 41 ? 2.433 -4.867 -17.986 1.00 19.61 ? 110 SER B CA 1 ATOM 3311 C C . SER B 1 41 ? 3.900 -4.521 -18.198 1.00 18.93 ? 110 SER B C 1 ATOM 3312 O O . SER B 1 41 ? 4.361 -4.428 -19.373 1.00 19.32 ? 110 SER B O 1 ATOM 3313 C CB . SER B 1 41 ? 2.271 -6.232 -17.255 1.00 20.09 ? 110 SER B CB 1 ATOM 3314 O OG . SER B 1 41 ? 0.929 -6.428 -16.747 1.00 20.24 ? 110 SER B OG 1 ATOM 3315 N N . ALA B 1 42 ? 4.621 -4.351 -17.072 1.00 17.48 ? 111 ALA B N 1 ATOM 3316 C CA . ALA B 1 42 ? 6.040 -3.955 -17.055 1.00 17.29 ? 111 ALA B CA 1 ATOM 3317 C C . ALA B 1 42 ? 6.918 -4.736 -16.066 1.00 16.86 ? 111 ALA B C 1 ATOM 3318 O O . ALA B 1 42 ? 7.522 -4.162 -15.176 1.00 16.86 ? 111 ALA B O 1 ATOM 3319 C CB . ALA B 1 42 ? 6.175 -2.450 -16.791 1.00 16.88 ? 111 ALA B CB 1 ATOM 3320 N N . PRO B 1 43 ? 7.025 -6.048 -16.254 1.00 16.46 ? 112 PRO B N 1 ATOM 3321 C CA . PRO B 1 43 ? 7.938 -6.822 -15.448 1.00 16.05 ? 112 PRO B CA 1 ATOM 3322 C C . PRO B 1 43 ? 9.363 -6.373 -15.640 1.00 16.06 ? 112 PRO B C 1 ATOM 3323 O O . PRO B 1 43 ? 9.817 -6.109 -16.806 1.00 14.58 ? 112 PRO B O 1 ATOM 3324 C CB . PRO B 1 43 ? 7.778 -8.247 -15.990 1.00 15.96 ? 112 PRO B CB 1 ATOM 3325 C CG . PRO B 1 43 ? 7.198 -8.095 -17.348 1.00 16.17 ? 112 PRO B CG 1 ATOM 3326 C CD . PRO B 1 43 ? 6.317 -6.889 -17.235 1.00 16.81 ? 112 PRO B CD 1 ATOM 3327 N N . LEU B 1 44 ? 10.069 -6.292 -14.508 1.00 14.87 ? 113 LEU B N 1 ATOM 3328 C CA . LEU B 1 44 ? 11.462 -5.867 -14.536 1.00 14.69 ? 113 LEU B CA 1 ATOM 3329 C C . LEU B 1 44 ? 12.348 -6.985 -15.055 1.00 14.46 ? 113 LEU B C 1 ATOM 3330 O O . LEU B 1 44 ? 12.021 -8.176 -14.904 1.00 14.08 ? 113 LEU B O 1 ATOM 3331 C CB . LEU B 1 44 ? 11.933 -5.422 -13.148 1.00 14.84 ? 113 LEU B CB 1 ATOM 3332 C CG . LEU B 1 44 ? 11.400 -4.079 -12.677 1.00 14.64 ? 113 LEU B CG 1 ATOM 3333 C CD1 . LEU B 1 44 ? 11.942 -3.771 -11.250 1.00 13.78 ? 113 LEU B CD1 1 ATOM 3334 C CD2 . LEU B 1 44 ? 11.738 -2.989 -13.683 1.00 14.29 ? 113 LEU B CD2 1 ATOM 3335 N N . ILE B 1 45 ? 13.461 -6.596 -15.681 1.00 14.18 ? 114 ILE B N 1 ATOM 3336 C CA . ILE B 1 45 ? 14.410 -7.536 -16.236 1.00 14.20 ? 114 ILE B CA 1 ATOM 3337 C C . ILE B 1 45 ? 15.430 -7.832 -15.147 1.00 14.66 ? 114 ILE B C 1 ATOM 3338 O O . ILE B 1 45 ? 16.204 -6.962 -14.780 1.00 14.94 ? 114 ILE B O 1 ATOM 3339 C CB . ILE B 1 45 ? 15.053 -7.010 -17.581 1.00 13.81 ? 114 ILE B CB 1 ATOM 3340 C CG1 . ILE B 1 45 ? 14.043 -7.132 -18.727 1.00 13.27 ? 114 ILE B CG1 1 ATOM 3341 C CG2 . ILE B 1 45 ? 16.289 -7.799 -17.962 1.00 11.66 ? 114 ILE B CG2 1 ATOM 3342 C CD1 . ILE B 1 45 ? 14.525 -6.530 -20.099 1.00 8.43 ? 114 ILE B CD1 1 ATOM 3343 N N . ILE B 1 46 ? 15.398 -9.060 -14.613 1.00 15.64 ? 115 ILE B N 1 ATOM 3344 C CA . ILE B 1 46 ? 16.201 -9.438 -13.456 1.00 15.73 ? 115 ILE B CA 1 ATOM 3345 C C . ILE B 1 46 ? 17.076 -10.693 -13.679 1.00 16.00 ? 115 ILE B C 1 ATOM 3346 O O . ILE B 1 46 ? 17.046 -11.351 -14.771 1.00 15.42 ? 115 ILE B O 1 ATOM 3347 C CB . ILE B 1 46 ? 15.341 -9.598 -12.143 1.00 16.58 ? 115 ILE B CB 1 ATOM 3348 C CG1 . ILE B 1 46 ? 14.311 -10.726 -12.258 1.00 18.62 ? 115 ILE B CG1 1 ATOM 3349 C CG2 . ILE B 1 46 ? 14.634 -8.288 -11.787 1.00 16.62 ? 115 ILE B CG2 1 ATOM 3350 C CD1 . ILE B 1 46 ? 14.900 -12.155 -12.196 1.00 21.68 ? 115 ILE B CD1 1 ATOM 3351 N N . ARG B 1 47 ? 17.893 -10.950 -12.651 1.00 14.48 ? 116 ARG B N 1 ATOM 3352 C CA . ARG B 1 47 ? 18.611 -12.186 -12.456 1.00 14.86 ? 116 ARG B CA 1 ATOM 3353 C C . ARG B 1 47 ? 19.149 -12.276 -11.007 1.00 14.83 ? 116 ARG B C 1 ATOM 3354 O O . ARG B 1 47 ? 18.989 -11.353 -10.191 1.00 14.31 ? 116 ARG B O 1 ATOM 3355 C CB . ARG B 1 47 ? 19.737 -12.340 -13.478 1.00 15.35 ? 116 ARG B CB 1 ATOM 3356 C CG . ARG B 1 47 ? 19.395 -13.262 -14.650 1.00 15.22 ? 116 ARG B CG 1 ATOM 3357 C CD . ARG B 1 47 ? 20.646 -14.028 -15.109 1.00 18.67 ? 116 ARG B CD 1 ATOM 3358 N NE . ARG B 1 47 ? 21.024 -15.082 -14.166 1.00 18.06 ? 116 ARG B NE 1 ATOM 3359 C CZ . ARG B 1 47 ? 22.253 -15.591 -14.017 1.00 19.20 ? 116 ARG B CZ 1 ATOM 3360 N NH1 . ARG B 1 47 ? 23.274 -15.134 -14.720 1.00 17.48 ? 116 ARG B NH1 1 ATOM 3361 N NH2 . ARG B 1 47 ? 22.472 -16.576 -13.139 1.00 19.47 ? 116 ARG B NH2 1 ATOM 3362 N N . GLU B 1 48 ? 19.744 -13.400 -10.674 1.00 14.79 ? 117 GLU B N 1 ATOM 3363 C CA . GLU B 1 48 ? 20.135 -13.648 -9.281 1.00 15.34 ? 117 GLU B CA 1 ATOM 3364 C C . GLU B 1 48 ? 19.019 -13.279 -8.279 1.00 14.52 ? 117 GLU B C 1 ATOM 3365 O O . GLU B 1 48 ? 19.226 -12.426 -7.432 1.00 13.34 ? 117 GLU B O 1 ATOM 3366 C CB . GLU B 1 48 ? 21.414 -12.862 -8.938 1.00 15.72 ? 117 GLU B CB 1 ATOM 3367 C CG . GLU B 1 48 ? 22.621 -13.233 -9.796 1.00 17.00 ? 117 GLU B CG 1 ATOM 3368 C CD . GLU B 1 48 ? 22.687 -12.442 -11.119 1.00 19.23 ? 117 GLU B CD 1 ATOM 3369 O OE1 . GLU B 1 48 ? 22.258 -11.268 -11.160 1.00 19.84 ? 117 GLU B OE1 1 ATOM 3370 O OE2 . GLU B 1 48 ? 23.184 -13.004 -12.111 1.00 17.49 ? 117 GLU B OE2 1 ATOM 3371 N N . PRO B 1 49 ? 17.824 -13.909 -8.397 1.00 14.81 ? 118 PRO B N 1 ATOM 3372 C CA . PRO B 1 49 ? 16.813 -13.689 -7.372 1.00 14.87 ? 118 PRO B CA 1 ATOM 3373 C C . PRO B 1 49 ? 17.158 -14.451 -6.112 1.00 15.38 ? 118 PRO B C 1 ATOM 3374 O O . PRO B 1 49 ? 17.936 -15.376 -6.149 1.00 14.85 ? 118 PRO B O 1 ATOM 3375 C CB . PRO B 1 49 ? 15.544 -14.249 -7.997 1.00 15.17 ? 118 PRO B CB 1 ATOM 3376 C CG . PRO B 1 49 ? 16.005 -15.252 -8.983 1.00 14.39 ? 118 PRO B CG 1 ATOM 3377 C CD . PRO B 1 49 ? 17.344 -14.816 -9.454 1.00 14.70 ? 118 PRO B CD 1 ATOM 3378 N N . PHE B 1 50 ? 16.621 -14.005 -4.992 1.00 16.32 ? 119 PHE B N 1 ATOM 3379 C CA . PHE B 1 50 ? 16.704 -14.752 -3.743 1.00 16.47 ? 119 PHE B CA 1 ATOM 3380 C C . PHE B 1 50 ? 15.605 -14.279 -2.826 1.00 16.11 ? 119 PHE B C 1 ATOM 3381 O O . PHE B 1 50 ? 14.948 -13.292 -3.118 1.00 16.32 ? 119 PHE B O 1 ATOM 3382 C CB . PHE B 1 50 ? 18.094 -14.668 -3.107 1.00 16.37 ? 119 PHE B CB 1 ATOM 3383 C CG . PHE B 1 50 ? 18.479 -13.312 -2.565 1.00 17.44 ? 119 PHE B CG 1 ATOM 3384 C CD1 . PHE B 1 50 ? 18.240 -12.989 -1.233 1.00 18.76 ? 119 PHE B CD1 1 ATOM 3385 C CD2 . PHE B 1 50 ? 19.172 -12.402 -3.348 1.00 17.75 ? 119 PHE B CD2 1 ATOM 3386 C CE1 . PHE B 1 50 ? 18.639 -11.762 -0.708 1.00 18.07 ? 119 PHE B CE1 1 ATOM 3387 C CE2 . PHE B 1 50 ? 19.564 -11.180 -2.835 1.00 17.74 ? 119 PHE B CE2 1 ATOM 3388 C CZ . PHE B 1 50 ? 19.303 -10.858 -1.520 1.00 18.11 ? 119 PHE B CZ 1 ATOM 3389 N N . ILE B 1 51 ? 15.374 -15.005 -1.745 1.00 15.98 ? 120 ILE B N 1 ATOM 3390 C CA . ILE B 1 51 ? 14.326 -14.653 -0.805 1.00 15.44 ? 120 ILE B CA 1 ATOM 3391 C C . ILE B 1 51 ? 14.935 -14.647 0.593 1.00 16.93 ? 120 ILE B C 1 ATOM 3392 O O . ILE B 1 51 ? 15.822 -15.451 0.915 1.00 16.58 ? 120 ILE B O 1 ATOM 3393 C CB . ILE B 1 51 ? 13.101 -15.639 -0.909 1.00 15.25 ? 120 ILE B CB 1 ATOM 3394 C CG1 . ILE B 1 51 ? 12.441 -15.514 -2.295 1.00 14.20 ? 120 ILE B CG1 1 ATOM 3395 C CG2 . ILE B 1 51 ? 12.045 -15.408 0.224 1.00 12.29 ? 120 ILE B CG2 1 ATOM 3396 C CD1 . ILE B 1 51 ? 11.805 -16.773 -2.747 1.00 10.39 ? 120 ILE B CD1 1 ATOM 3397 N N . ALA B 1 52 ? 14.465 -13.717 1.416 1.00 17.88 ? 121 ALA B N 1 ATOM 3398 C CA . ALA B 1 52 ? 14.831 -13.666 2.831 1.00 17.79 ? 121 ALA B CA 1 ATOM 3399 C C . ALA B 1 52 ? 13.582 -13.270 3.596 1.00 18.57 ? 121 ALA B C 1 ATOM 3400 O O . ALA B 1 52 ? 12.768 -12.489 3.102 1.00 17.95 ? 121 ALA B O 1 ATOM 3401 C CB . ALA B 1 52 ? 15.908 -12.651 3.045 1.00 18.22 ? 121 ALA B CB 1 ATOM 3402 N N . CYS B 1 53 ? 13.442 -13.798 4.803 1.00 19.59 ? 122 CYS B N 1 ATOM 3403 C CA . CYS B 1 53 ? 12.242 -13.606 5.598 1.00 20.85 ? 122 CYS B CA 1 ATOM 3404 C C . CYS B 1 53 ? 12.566 -12.984 6.961 1.00 21.95 ? 122 CYS B C 1 ATOM 3405 O O . CYS B 1 53 ? 13.575 -13.303 7.563 1.00 21.06 ? 122 CYS B O 1 ATOM 3406 C CB . CYS B 1 53 ? 11.530 -14.955 5.812 1.00 20.65 ? 122 CYS B CB 1 ATOM 3407 S SG . CYS B 1 53 ? 10.912 -15.785 4.282 1.00 20.05 ? 122 CYS B SG 1 ATOM 3408 N N . GLY B 1 54 ? 11.693 -12.083 7.416 1.00 23.42 ? 123 GLY B N 1 ATOM 3409 C CA . GLY B 1 54 ? 11.683 -11.611 8.815 1.00 24.47 ? 123 GLY B CA 1 ATOM 3410 C C . GLY B 1 54 ? 10.524 -12.195 9.620 1.00 25.22 ? 123 GLY B C 1 ATOM 3411 O O . GLY B 1 54 ? 9.817 -13.084 9.141 1.00 24.76 ? 123 GLY B O 1 ATOM 3412 N N . PRO B 1 55 ? 10.337 -11.724 10.866 1.00 26.47 ? 124 PRO B N 1 ATOM 3413 C CA . PRO B 1 55 ? 9.286 -12.287 11.710 1.00 27.17 ? 124 PRO B CA 1 ATOM 3414 C C . PRO B 1 55 ? 7.867 -11.997 11.217 1.00 27.87 ? 124 PRO B C 1 ATOM 3415 O O . PRO B 1 55 ? 6.934 -12.671 11.659 1.00 27.95 ? 124 PRO B O 1 ATOM 3416 C CB . PRO B 1 55 ? 9.521 -11.611 13.068 1.00 27.30 ? 124 PRO B CB 1 ATOM 3417 C CG . PRO B 1 55 ? 10.288 -10.400 12.763 1.00 26.69 ? 124 PRO B CG 1 ATOM 3418 C CD . PRO B 1 55 ? 11.175 -10.784 11.626 1.00 26.78 ? 124 PRO B CD 1 ATOM 3419 N N . LYS B 1 56 ? 7.690 -11.026 10.316 1.00 28.55 ? 125 LYS B N 1 ATOM 3420 C CA . LYS B 1 56 ? 6.356 -10.740 9.798 1.00 28.83 ? 125 LYS B CA 1 ATOM 3421 C C . LYS B 1 56 ? 6.191 -11.050 8.306 1.00 28.59 ? 125 LYS B C 1 ATOM 3422 O O . LYS B 1 56 ? 5.070 -11.297 7.864 1.00 28.76 ? 125 LYS B O 1 ATOM 3423 C CB . LYS B 1 56 ? 5.937 -9.293 10.115 1.00 29.29 ? 125 LYS B CB 1 ATOM 3424 C CG . LYS B 1 56 ? 6.236 -8.237 9.011 1.00 31.74 ? 125 LYS B CG 1 ATOM 3425 C CD . LYS B 1 56 ? 5.400 -6.933 9.159 1.00 33.98 ? 125 LYS B CD 1 ATOM 3426 C CE . LYS B 1 56 ? 4.234 -6.868 8.147 1.00 35.25 ? 125 LYS B CE 1 ATOM 3427 N NZ . LYS B 1 56 ? 3.206 -5.830 8.486 1.00 36.23 ? 125 LYS B NZ 1 ATOM 3428 N N . GLU B 1 57 ? 7.281 -11.061 7.537 1.00 27.97 ? 126 GLU B N 1 ATOM 3429 C CA . GLU B 1 57 ? 7.176 -10.952 6.077 1.00 28.10 ? 126 GLU B CA 1 ATOM 3430 C C . GLU B 1 57 ? 8.369 -11.566 5.378 1.00 26.47 ? 126 GLU B C 1 ATOM 3431 O O . GLU B 1 57 ? 9.481 -11.566 5.903 1.00 26.50 ? 126 GLU B O 1 ATOM 3432 C CB . GLU B 1 57 ? 7.106 -9.463 5.683 1.00 29.03 ? 126 GLU B CB 1 ATOM 3433 C CG . GLU B 1 57 ? 6.797 -9.190 4.198 1.00 32.74 ? 126 GLU B CG 1 ATOM 3434 C CD . GLU B 1 57 ? 7.358 -7.853 3.693 1.00 36.10 ? 126 GLU B CD 1 ATOM 3435 O OE1 . GLU B 1 57 ? 7.676 -6.968 4.541 1.00 37.27 ? 126 GLU B OE1 1 ATOM 3436 O OE2 . GLU B 1 57 ? 7.482 -7.705 2.443 1.00 35.95 ? 126 GLU B OE2 1 ATOM 3437 N N . CYS B 1 58 ? 8.128 -12.101 4.194 1.00 24.58 ? 127 CYS B N 1 ATOM 3438 C CA . CYS B 1 58 ? 9.204 -12.539 3.328 1.00 23.34 ? 127 CYS B CA 1 ATOM 3439 C C . CYS B 1 58 ? 9.337 -11.551 2.187 1.00 21.40 ? 127 CYS B C 1 ATOM 3440 O O . CYS B 1 58 ? 8.341 -11.124 1.610 1.00 21.15 ? 127 CYS B O 1 ATOM 3441 C CB . CYS B 1 58 ? 8.956 -13.957 2.801 1.00 23.26 ? 127 CYS B CB 1 ATOM 3442 S SG . CYS B 1 58 ? 8.932 -15.219 4.094 1.00 26.09 ? 127 CYS B SG 1 ATOM 3443 N N . LYS B 1 59 ? 10.580 -11.188 1.881 1.00 19.74 ? 128 LYS B N 1 ATOM 3444 C CA . LYS B 1 59 ? 10.899 -10.336 0.728 1.00 18.48 ? 128 LYS B CA 1 ATOM 3445 C C . LYS B 1 59 ? 11.562 -11.120 -0.413 1.00 17.47 ? 128 LYS B C 1 ATOM 3446 O O . LYS B 1 59 ? 12.429 -11.957 -0.184 1.00 16.44 ? 128 LYS B O 1 ATOM 3447 C CB . LYS B 1 59 ? 11.792 -9.167 1.179 1.00 18.29 ? 128 LYS B CB 1 ATOM 3448 C CG . LYS B 1 59 ? 10.994 -8.019 1.781 1.00 17.47 ? 128 LYS B CG 1 ATOM 3449 C CD . LYS B 1 59 ? 11.888 -6.894 2.250 1.00 16.27 ? 128 LYS B CD 1 ATOM 3450 C CE . LYS B 1 59 ? 11.062 -5.791 2.826 1.00 16.35 ? 128 LYS B CE 1 ATOM 3451 N NZ . LYS B 1 59 ? 11.952 -4.648 3.244 1.00 20.40 ? 128 LYS B NZ 1 ATOM 3452 N N . HIS B 1 60 ? 11.142 -10.826 -1.644 1.00 17.30 ? 129 HIS B N 1 ATOM 3453 C CA . HIS B 1 60 ? 11.686 -11.445 -2.865 1.00 16.26 ? 129 HIS B CA 1 ATOM 3454 C C . HIS B 1 60 ? 12.610 -10.421 -3.513 1.00 15.96 ? 129 HIS B C 1 ATOM 3455 O O . HIS B 1 60 ? 12.164 -9.371 -3.987 1.00 15.91 ? 129 HIS B O 1 ATOM 3456 C CB . HIS B 1 60 ? 10.520 -11.840 -3.762 1.00 17.00 ? 129 HIS B CB 1 ATOM 3457 C CG . HIS B 1 60 ? 10.907 -12.467 -5.066 1.00 16.31 ? 129 HIS B CG 1 ATOM 3458 N ND1 . HIS B 1 60 ? 10.034 -12.554 -6.127 1.00 15.38 ? 129 HIS B ND1 1 ATOM 3459 C CD2 . HIS B 1 60 ? 12.049 -13.067 -5.470 1.00 17.36 ? 129 HIS B CD2 1 ATOM 3460 C CE1 . HIS B 1 60 ? 10.632 -13.158 -7.137 1.00 16.12 ? 129 HIS B CE1 1 ATOM 3461 N NE2 . HIS B 1 60 ? 11.855 -13.480 -6.765 1.00 15.40 ? 129 HIS B NE2 1 ATOM 3462 N N . PHE B 1 61 ? 13.913 -10.692 -3.453 1.00 15.19 ? 130 PHE B N 1 ATOM 3463 C CA . PHE B 1 61 ? 14.929 -9.776 -3.937 1.00 14.25 ? 130 PHE B CA 1 ATOM 3464 C C . PHE B 1 61 ? 15.433 -10.218 -5.299 1.00 14.11 ? 130 PHE B C 1 ATOM 3465 O O . PHE B 1 61 ? 15.335 -11.391 -5.632 1.00 14.42 ? 130 PHE B O 1 ATOM 3466 C CB . PHE B 1 61 ? 16.117 -9.764 -3.011 1.00 13.67 ? 130 PHE B CB 1 ATOM 3467 C CG . PHE B 1 61 ? 15.845 -9.184 -1.678 1.00 11.83 ? 130 PHE B CG 1 ATOM 3468 C CD1 . PHE B 1 61 ? 16.108 -7.849 -1.425 1.00 11.61 ? 130 PHE B CD1 1 ATOM 3469 C CD2 . PHE B 1 61 ? 15.394 -9.985 -0.639 1.00 9.93 ? 130 PHE B CD2 1 ATOM 3470 C CE1 . PHE B 1 61 ? 15.887 -7.317 -0.128 1.00 12.28 ? 130 PHE B CE1 1 ATOM 3471 C CE2 . PHE B 1 61 ? 15.173 -9.470 0.633 1.00 8.24 ? 130 PHE B CE2 1 ATOM 3472 C CZ . PHE B 1 61 ? 15.418 -8.142 0.887 1.00 8.51 ? 130 PHE B CZ 1 ATOM 3473 N N . ALA B 1 62 ? 15.974 -9.282 -6.069 1.00 13.50 ? 131 ALA B N 1 ATOM 3474 C CA . ALA B 1 62 ? 16.694 -9.613 -7.307 1.00 14.13 ? 131 ALA B CA 1 ATOM 3475 C C . ALA B 1 62 ? 17.598 -8.446 -7.743 1.00 14.48 ? 131 ALA B C 1 ATOM 3476 O O . ALA B 1 62 ? 17.549 -7.354 -7.189 1.00 14.33 ? 131 ALA B O 1 ATOM 3477 C CB . ALA B 1 62 ? 15.706 -10.024 -8.442 1.00 13.44 ? 131 ALA B CB 1 ATOM 3478 N N . LEU B 1 63 ? 18.478 -8.697 -8.700 1.00 15.73 ? 132 LEU B N 1 ATOM 3479 C CA . LEU B 1 63 ? 19.255 -7.633 -9.308 1.00 15.42 ? 132 LEU B CA 1 ATOM 3480 C C . LEU B 1 63 ? 18.645 -7.367 -10.676 1.00 15.74 ? 132 LEU B C 1 ATOM 3481 O O . LEU B 1 63 ? 18.595 -8.247 -11.531 1.00 15.48 ? 132 LEU B O 1 ATOM 3482 C CB . LEU B 1 63 ? 20.724 -8.015 -9.432 1.00 15.43 ? 132 LEU B CB 1 ATOM 3483 C CG . LEU B 1 63 ? 21.537 -8.270 -8.157 1.00 15.93 ? 132 LEU B CG 1 ATOM 3484 C CD1 . LEU B 1 63 ? 22.867 -8.961 -8.467 1.00 12.78 ? 132 LEU B CD1 1 ATOM 3485 C CD2 . LEU B 1 63 ? 21.812 -6.973 -7.401 1.00 16.74 ? 132 LEU B CD2 1 ATOM 3486 N N . THR B 1 64 ? 18.186 -6.141 -10.874 1.00 16.20 ? 133 THR B N 1 ATOM 3487 C CA . THR B 1 64 ? 17.561 -5.731 -12.116 1.00 16.27 ? 133 THR B CA 1 ATOM 3488 C C . THR B 1 64 ? 18.554 -4.962 -12.963 1.00 16.57 ? 133 THR B C 1 ATOM 3489 O O . THR B 1 64 ? 19.449 -4.318 -12.405 1.00 16.38 ? 133 THR B O 1 ATOM 3490 C CB . THR B 1 64 ? 16.326 -4.832 -11.839 1.00 16.60 ? 133 THR B CB 1 ATOM 3491 O OG1 . THR B 1 64 ? 15.664 -4.534 -13.076 1.00 16.82 ? 133 THR B OG1 1 ATOM 3492 C CG2 . THR B 1 64 ? 16.726 -3.557 -11.131 1.00 16.00 ? 133 THR B CG2 1 ATOM 3493 N N . HIS B 1 65 ? 18.388 -5.055 -14.298 1.00 16.10 ? 134 HIS B N 1 ATOM 3494 C CA . HIS B 1 65 ? 19.074 -4.192 -15.276 1.00 15.85 ? 134 HIS B CA 1 ATOM 3495 C C . HIS B 1 65 ? 18.458 -2.773 -15.511 1.00 16.19 ? 134 HIS B C 1 ATOM 3496 O O . HIS B 1 65 ? 18.933 -2.025 -16.393 1.00 15.54 ? 134 HIS B O 1 ATOM 3497 C CB . HIS B 1 65 ? 19.183 -4.915 -16.640 1.00 15.88 ? 134 HIS B CB 1 ATOM 3498 C CG . HIS B 1 65 ? 20.316 -5.899 -16.720 1.00 15.15 ? 134 HIS B CG 1 ATOM 3499 N ND1 . HIS B 1 65 ? 21.635 -5.504 -16.773 1.00 13.15 ? 134 HIS B ND1 1 ATOM 3500 C CD2 . HIS B 1 65 ? 20.327 -7.258 -16.753 1.00 13.97 ? 134 HIS B CD2 1 ATOM 3501 C CE1 . HIS B 1 65 ? 22.407 -6.574 -16.855 1.00 13.79 ? 134 HIS B CE1 1 ATOM 3502 N NE2 . HIS B 1 65 ? 21.641 -7.653 -16.823 1.00 10.96 ? 134 HIS B NE2 1 ATOM 3503 N N . TYR B 1 66 ? 17.443 -2.394 -14.724 1.00 16.22 ? 135 TYR B N 1 ATOM 3504 C CA . TYR B 1 66 ? 16.794 -1.079 -14.817 1.00 16.48 ? 135 TYR B CA 1 ATOM 3505 C C . TYR B 1 66 ? 16.053 -0.951 -16.184 1.00 17.07 ? 135 TYR B C 1 ATOM 3506 O O . TYR B 1 66 ? 16.104 0.090 -16.861 1.00 16.58 ? 135 TYR B O 1 ATOM 3507 C CB . TYR B 1 66 ? 17.804 0.081 -14.566 1.00 16.85 ? 135 TYR B CB 1 ATOM 3508 C CG . TYR B 1 66 ? 17.341 1.110 -13.529 1.00 16.39 ? 135 TYR B CG 1 ATOM 3509 C CD1 . TYR B 1 66 ? 16.252 1.922 -13.776 1.00 17.59 ? 135 TYR B CD1 1 ATOM 3510 C CD2 . TYR B 1 66 ? 17.987 1.241 -12.307 1.00 15.76 ? 135 TYR B CD2 1 ATOM 3511 C CE1 . TYR B 1 66 ? 15.801 2.826 -12.841 1.00 17.08 ? 135 TYR B CE1 1 ATOM 3512 C CE2 . TYR B 1 66 ? 17.558 2.153 -11.359 1.00 16.26 ? 135 TYR B CE2 1 ATOM 3513 C CZ . TYR B 1 66 ? 16.460 2.939 -11.627 1.00 18.01 ? 135 TYR B CZ 1 ATOM 3514 O OH . TYR B 1 66 ? 16.010 3.855 -10.709 1.00 15.74 ? 135 TYR B OH 1 ATOM 3515 N N . ALA B 1 67 ? 15.345 -2.025 -16.531 1.00 16.46 ? 136 ALA B N 1 ATOM 3516 C CA . ALA B 1 67 ? 14.699 -2.205 -17.829 1.00 16.76 ? 136 ALA B CA 1 ATOM 3517 C C . ALA B 1 67 ? 13.497 -3.112 -17.634 1.00 16.89 ? 136 ALA B C 1 ATOM 3518 O O . ALA B 1 67 ? 13.473 -3.943 -16.721 1.00 18.37 ? 136 ALA B O 1 ATOM 3519 C CB . ALA B 1 67 ? 15.656 -2.826 -18.801 1.00 16.71 ? 136 ALA B CB 1 ATOM 3520 N N . ALA B 1 68 ? 12.493 -2.939 -18.473 1.00 17.04 ? 137 ALA B N 1 ATOM 3521 C CA . ALA B 1 68 ? 11.282 -3.736 -18.429 1.00 16.54 ? 137 ALA B CA 1 ATOM 3522 C C . ALA B 1 68 ? 11.069 -4.442 -19.777 1.00 16.79 ? 137 ALA B C 1 ATOM 3523 O O . ALA B 1 68 ? 11.681 -4.068 -20.791 1.00 16.21 ? 137 ALA B O 1 ATOM 3524 C CB . ALA B 1 68 ? 10.091 -2.830 -18.110 1.00 16.37 ? 137 ALA B CB 1 ATOM 3525 N N . GLN B 1 69 ? 10.223 -5.476 -19.751 1.00 16.84 ? 138 GLN B N 1 ATOM 3526 C CA . GLN B 1 69 ? 9.711 -6.125 -20.942 1.00 17.03 ? 138 GLN B CA 1 ATOM 3527 C C . GLN B 1 69 ? 8.202 -5.939 -20.995 1.00 16.91 ? 138 GLN B C 1 ATOM 3528 O O . GLN B 1 69 ? 7.529 -6.273 -20.030 1.00 17.77 ? 138 GLN B O 1 ATOM 3529 C CB . GLN B 1 69 ? 10.011 -7.624 -20.941 1.00 17.57 ? 138 GLN B CB 1 ATOM 3530 C CG . GLN B 1 69 ? 9.534 -8.319 -22.231 1.00 16.47 ? 138 GLN B CG 1 ATOM 3531 C CD . GLN B 1 69 ? 9.114 -9.732 -22.053 1.00 17.53 ? 138 GLN B CD 1 ATOM 3532 O OE1 . GLN B 1 69 ? 8.967 -10.239 -20.914 1.00 15.01 ? 138 GLN B OE1 1 ATOM 3533 N NE2 . GLN B 1 69 ? 8.907 -10.416 -23.192 1.00 16.23 ? 138 GLN B NE2 1 ATOM 3534 N N . PRO B 1 70 ? 7.663 -5.415 -22.118 1.00 17.12 ? 139 PRO B N 1 ATOM 3535 C CA . PRO B 1 70 ? 8.402 -5.084 -23.361 1.00 17.48 ? 139 PRO B CA 1 ATOM 3536 C C . PRO B 1 70 ? 9.160 -3.752 -23.245 1.00 17.71 ? 139 PRO B C 1 ATOM 3537 O O . PRO B 1 70 ? 8.753 -2.868 -22.499 1.00 18.14 ? 139 PRO B O 1 ATOM 3538 C CB . PRO B 1 70 ? 7.294 -5.003 -24.415 1.00 17.17 ? 139 PRO B CB 1 ATOM 3539 C CG . PRO B 1 70 ? 6.119 -4.515 -23.668 1.00 17.65 ? 139 PRO B CG 1 ATOM 3540 C CD . PRO B 1 70 ? 6.218 -5.162 -22.272 1.00 16.84 ? 139 PRO B CD 1 ATOM 3541 N N . GLY B 1 71 ? 10.259 -3.611 -23.967 1.00 17.86 ? 140 GLY B N 1 ATOM 3542 C CA . GLY B 1 71 ? 11.067 -2.391 -23.855 1.00 17.90 ? 140 GLY B CA 1 ATOM 3543 C C . GLY B 1 71 ? 12.116 -2.210 -24.937 1.00 17.66 ? 140 GLY B C 1 ATOM 3544 O O . GLY B 1 71 ? 12.155 -2.946 -25.925 1.00 16.27 ? 140 GLY B O 1 ATOM 3545 N N . GLY B 1 72 ? 12.964 -1.212 -24.737 1.00 18.15 ? 141 GLY B N 1 ATOM 3546 C CA . GLY B 1 72 ? 14.005 -0.883 -25.701 1.00 18.81 ? 141 GLY B CA 1 ATOM 3547 C C . GLY B 1 72 ? 15.435 -1.013 -25.193 1.00 18.89 ? 141 GLY B C 1 ATOM 3548 O O . GLY B 1 72 ? 16.356 -0.690 -25.942 1.00 19.59 ? 141 GLY B O 1 ATOM 3549 N N . TYR B 1 73 ? 15.637 -1.467 -23.947 1.00 18.10 ? 142 TYR B N 1 ATOM 3550 C CA . TYR B 1 73 ? 16.996 -1.546 -23.377 1.00 17.86 ? 142 TYR B CA 1 ATOM 3551 C C . TYR B 1 73 ? 17.476 -2.973 -23.122 1.00 17.49 ? 142 TYR B C 1 ATOM 3552 O O . TYR B 1 73 ? 18.219 -3.218 -22.170 1.00 18.10 ? 142 TYR B O 1 ATOM 3553 C CB . TYR B 1 73 ? 17.100 -0.735 -22.084 1.00 17.70 ? 142 TYR B CB 1 ATOM 3554 C CG . TYR B 1 73 ? 16.802 0.714 -22.275 1.00 16.01 ? 142 TYR B CG 1 ATOM 3555 C CD1 . TYR B 1 73 ? 17.707 1.548 -22.918 1.00 15.46 ? 142 TYR B CD1 1 ATOM 3556 C CD2 . TYR B 1 73 ? 15.610 1.258 -21.806 1.00 13.60 ? 142 TYR B CD2 1 ATOM 3557 C CE1 . TYR B 1 73 ? 17.414 2.906 -23.112 1.00 15.25 ? 142 TYR B CE1 1 ATOM 3558 C CE2 . TYR B 1 73 ? 15.308 2.578 -22.003 1.00 15.29 ? 142 TYR B CE2 1 ATOM 3559 C CZ . TYR B 1 73 ? 16.206 3.404 -22.655 1.00 14.99 ? 142 TYR B CZ 1 ATOM 3560 O OH . TYR B 1 73 ? 15.867 4.720 -22.818 1.00 14.66 ? 142 TYR B OH 1 ATOM 3561 N N . TYR B 1 74 ? 17.077 -3.888 -23.999 1.00 17.28 ? 143 TYR B N 1 ATOM 3562 C CA . TYR B 1 74 ? 17.447 -5.316 -23.916 1.00 17.19 ? 143 TYR B CA 1 ATOM 3563 C C . TYR B 1 74 ? 18.918 -5.534 -24.109 1.00 16.74 ? 143 TYR B C 1 ATOM 3564 O O . TYR B 1 74 ? 19.492 -6.502 -23.569 1.00 16.92 ? 143 TYR B O 1 ATOM 3565 C CB . TYR B 1 74 ? 16.738 -6.124 -25.009 1.00 16.67 ? 143 TYR B CB 1 ATOM 3566 C CG . TYR B 1 74 ? 15.227 -6.178 -24.899 1.00 17.39 ? 143 TYR B CG 1 ATOM 3567 C CD1 . TYR B 1 74 ? 14.547 -5.843 -23.699 1.00 14.59 ? 143 TYR B CD1 1 ATOM 3568 C CD2 . TYR B 1 74 ? 14.478 -6.630 -25.971 1.00 14.84 ? 143 TYR B CD2 1 ATOM 3569 C CE1 . TYR B 1 74 ? 13.162 -5.902 -23.635 1.00 15.28 ? 143 TYR B CE1 1 ATOM 3570 C CE2 . TYR B 1 74 ? 13.122 -6.701 -25.909 1.00 16.10 ? 143 TYR B CE2 1 ATOM 3571 C CZ . TYR B 1 74 ? 12.453 -6.349 -24.740 1.00 17.08 ? 143 TYR B CZ 1 ATOM 3572 O OH . TYR B 1 74 ? 11.074 -6.464 -24.717 1.00 18.33 ? 143 TYR B OH 1 ATOM 3573 N N . ASN B 1 75 ? 19.523 -4.671 -24.924 1.00 16.32 ? 144 ASN B N 1 ATOM 3574 C CA . ASN B 1 75 ? 20.935 -4.762 -25.155 1.00 16.11 ? 144 ASN B CA 1 ATOM 3575 C C . ASN B 1 75 ? 21.685 -4.512 -23.863 1.00 16.58 ? 144 ASN B C 1 ATOM 3576 O O . ASN B 1 75 ? 21.481 -3.473 -23.222 1.00 15.82 ? 144 ASN B O 1 ATOM 3577 C CB . ASN B 1 75 ? 21.427 -3.767 -26.191 1.00 16.10 ? 144 ASN B CB 1 ATOM 3578 C CG . ASN B 1 75 ? 22.841 -4.057 -26.583 1.00 17.50 ? 144 ASN B CG 1 ATOM 3579 O OD1 . ASN B 1 75 ? 23.157 -5.213 -26.847 1.00 19.51 ? 144 ASN B OD1 1 ATOM 3580 N ND2 . ASN B 1 75 ? 23.721 -3.056 -26.547 1.00 19.18 ? 144 ASN B ND2 1 ATOM 3581 N N . GLY B 1 76 ? 22.582 -5.445 -23.530 1.00 16.98 ? 145 GLY B N 1 ATOM 3582 C CA . GLY B 1 76 ? 23.330 -5.430 -22.267 1.00 17.21 ? 145 GLY B CA 1 ATOM 3583 C C . GLY B 1 76 ? 22.725 -6.267 -21.152 1.00 17.20 ? 145 GLY B C 1 ATOM 3584 O O . GLY B 1 76 ? 23.350 -6.483 -20.125 1.00 17.54 ? 145 GLY B O 1 ATOM 3585 N N . THR B 1 77 ? 21.501 -6.742 -21.318 1.00 17.66 ? 146 THR B N 1 ATOM 3586 C CA . THR B 1 77 ? 20.830 -7.422 -20.200 1.00 17.68 ? 146 THR B CA 1 ATOM 3587 C C . THR B 1 77 ? 21.283 -8.865 -20.042 1.00 18.90 ? 146 THR B C 1 ATOM 3588 O O . THR B 1 77 ? 20.841 -9.554 -19.128 1.00 19.31 ? 146 THR B O 1 ATOM 3589 C CB . THR B 1 77 ? 19.311 -7.373 -20.333 1.00 17.49 ? 146 THR B CB 1 ATOM 3590 O OG1 . THR B 1 77 ? 18.895 -8.084 -21.517 1.00 16.89 ? 146 THR B OG1 1 ATOM 3591 C CG2 . THR B 1 77 ? 18.828 -5.920 -20.362 1.00 15.65 ? 146 THR B CG2 1 ATOM 3592 N N . ARG B 1 78 ? 22.158 -9.324 -20.934 1.00 20.30 ? 147 ARG B N 1 ATOM 3593 C CA . ARG B 1 78 ? 22.835 -10.599 -20.760 1.00 21.72 ? 147 ARG B CA 1 ATOM 3594 C C . ARG B 1 78 ? 24.176 -10.515 -19.986 1.00 22.47 ? 147 ARG B C 1 ATOM 3595 O O . ARG B 1 78 ? 24.772 -11.553 -19.726 1.00 22.68 ? 147 ARG B O 1 ATOM 3596 C CB . ARG B 1 78 ? 23.050 -11.329 -22.110 1.00 21.91 ? 147 ARG B CB 1 ATOM 3597 C CG . ARG B 1 78 ? 22.689 -12.780 -21.966 1.00 22.93 ? 147 ARG B CG 1 ATOM 3598 C CD . ARG B 1 78 ? 23.168 -13.753 -23.008 1.00 24.92 ? 147 ARG B CD 1 ATOM 3599 N NE . ARG B 1 78 ? 23.385 -15.004 -22.306 1.00 28.69 ? 147 ARG B NE 1 ATOM 3600 C CZ . ARG B 1 78 ? 23.890 -16.115 -22.804 1.00 29.21 ? 147 ARG B CZ 1 ATOM 3601 N NH1 . ARG B 1 78 ? 24.194 -16.205 -24.090 1.00 33.97 ? 147 ARG B NH1 1 ATOM 3602 N NH2 . ARG B 1 78 ? 24.042 -17.160 -22.002 1.00 25.58 ? 147 ARG B NH2 1 ATOM 3603 N N . GLY B 1 79 ? 24.647 -9.307 -19.646 1.00 22.91 ? 148 GLY B N 1 ATOM 3604 C CA . GLY B 1 79 ? 25.835 -9.125 -18.789 1.00 22.92 ? 148 GLY B CA 1 ATOM 3605 C C . GLY B 1 79 ? 25.503 -9.012 -17.304 1.00 23.27 ? 148 GLY B C 1 ATOM 3606 O O . GLY B 1 79 ? 24.335 -8.961 -16.917 1.00 23.48 ? 148 GLY B O 1 ATOM 3607 N N . ASP B 1 80 ? 26.533 -8.991 -16.464 1.00 23.77 ? 149 ASP B N 1 ATOM 3608 C CA . ASP B 1 80 ? 26.360 -8.981 -15.002 1.00 23.91 ? 149 ASP B CA 1 ATOM 3609 C C . ASP B 1 80 ? 26.561 -7.584 -14.395 1.00 23.37 ? 149 ASP B C 1 ATOM 3610 O O . ASP B 1 80 ? 25.826 -7.162 -13.478 1.00 23.74 ? 149 ASP B O 1 ATOM 3611 C CB . ASP B 1 80 ? 27.360 -9.940 -14.347 1.00 24.74 ? 149 ASP B CB 1 ATOM 3612 C CG . ASP B 1 80 ? 27.185 -11.391 -14.801 1.00 27.17 ? 149 ASP B CG 1 ATOM 3613 O OD1 . ASP B 1 80 ? 26.060 -11.941 -14.695 1.00 29.62 ? 149 ASP B OD1 1 ATOM 3614 O OD2 . ASP B 1 80 ? 28.192 -11.984 -15.242 1.00 30.53 ? 149 ASP B OD2 1 ATOM 3615 N N . ARG B 1 81 ? 27.569 -6.884 -14.912 1.00 21.97 ? 150 ARG B N 1 ATOM 3616 C CA . ARG B 1 81 ? 28.099 -5.687 -14.287 1.00 21.24 ? 150 ARG B CA 1 ATOM 3617 C C . ARG B 1 81 ? 27.947 -4.484 -15.193 1.00 19.99 ? 150 ARG B C 1 ATOM 3618 O O . ARG B 1 81 ? 28.379 -4.481 -16.342 1.00 19.42 ? 150 ARG B O 1 ATOM 3619 C CB . ARG B 1 81 ? 29.562 -5.918 -13.902 1.00 20.83 ? 150 ARG B CB 1 ATOM 3620 C CG . ARG B 1 81 ? 29.686 -7.034 -12.864 1.00 21.98 ? 150 ARG B CG 1 ATOM 3621 C CD . ARG B 1 81 ? 31.093 -7.148 -12.289 1.00 23.56 ? 150 ARG B CD 1 ATOM 3622 N NE . ARG B 1 81 ? 32.096 -7.269 -13.363 1.00 22.59 ? 150 ARG B NE 1 ATOM 3623 C CZ . ARG B 1 81 ? 32.274 -8.346 -14.123 1.00 23.18 ? 150 ARG B CZ 1 ATOM 3624 N NH1 . ARG B 1 81 ? 31.532 -9.427 -13.957 1.00 22.67 ? 150 ARG B NH1 1 ATOM 3625 N NH2 . ARG B 1 81 ? 33.214 -8.346 -15.064 1.00 24.67 ? 150 ARG B NH2 1 ATOM 3626 N N . ASN B 1 82 ? 27.257 -3.491 -14.663 1.00 19.33 ? 151 ASN B N 1 ATOM 3627 C CA . ASN B 1 82 ? 27.081 -2.201 -15.311 1.00 18.68 ? 151 ASN B CA 1 ATOM 3628 C C . ASN B 1 82 ? 26.635 -1.203 -14.268 1.00 17.87 ? 151 ASN B C 1 ATOM 3629 O O . ASN B 1 82 ? 26.319 -1.572 -13.148 1.00 18.07 ? 151 ASN B O 1 ATOM 3630 C CB . ASN B 1 82 ? 26.119 -2.245 -16.531 1.00 18.54 ? 151 ASN B CB 1 ATOM 3631 C CG . ASN B 1 82 ? 24.679 -2.674 -16.180 1.00 19.77 ? 151 ASN B CG 1 ATOM 3632 O OD1 . ASN B 1 82 ? 24.020 -2.083 -15.313 1.00 19.82 ? 151 ASN B OD1 1 ATOM 3633 N ND2 . ASN B 1 82 ? 24.175 -3.677 -16.895 1.00 18.81 ? 151 ASN B ND2 1 ATOM 3634 N N . LYS B 1 83 ? 26.631 0.067 -14.660 1.00 17.69 ? 152 LYS B N 1 ATOM 3635 C CA . LYS B 1 83 ? 26.370 1.174 -13.772 1.00 16.39 ? 152 LYS B CA 1 ATOM 3636 C C . LYS B 1 83 ? 24.890 1.407 -13.537 1.00 16.32 ? 152 LYS B C 1 ATOM 3637 O O . LYS B 1 83 ? 24.525 2.363 -12.846 1.00 16.16 ? 152 LYS B O 1 ATOM 3638 C CB . LYS B 1 83 ? 26.980 2.435 -14.374 1.00 16.50 ? 152 LYS B CB 1 ATOM 3639 C CG . LYS B 1 83 ? 28.503 2.441 -14.405 1.00 16.45 ? 152 LYS B CG 1 ATOM 3640 C CD . LYS B 1 83 ? 29.013 3.704 -15.119 1.00 14.21 ? 152 LYS B CD 1 ATOM 3641 C CE . LYS B 1 83 ? 30.504 3.671 -15.312 1.00 12.95 ? 152 LYS B CE 1 ATOM 3642 N NZ . LYS B 1 83 ? 30.927 5.021 -15.783 1.00 13.40 ? 152 LYS B NZ 1 ATOM 3643 N N . LEU B 1 84 ? 24.021 0.567 -14.118 1.00 16.07 ? 153 LEU B N 1 ATOM 3644 C CA . LEU B 1 84 ? 22.561 0.708 -13.905 1.00 15.63 ? 153 LEU B CA 1 ATOM 3645 C C . LEU B 1 84 ? 22.004 -0.347 -12.956 1.00 15.82 ? 153 LEU B C 1 ATOM 3646 O O . LEU B 1 84 ? 20.920 -0.177 -12.402 1.00 16.53 ? 153 LEU B O 1 ATOM 3647 C CB . LEU B 1 84 ? 21.836 0.655 -15.234 1.00 15.18 ? 153 LEU B CB 1 ATOM 3648 C CG . LEU B 1 84 ? 22.097 1.901 -16.068 1.00 14.76 ? 153 LEU B CG 1 ATOM 3649 C CD1 . LEU B 1 84 ? 21.703 1.635 -17.496 1.00 14.29 ? 153 LEU B CD1 1 ATOM 3650 C CD2 . LEU B 1 84 ? 21.350 3.086 -15.508 1.00 15.10 ? 153 LEU B CD2 1 ATOM 3651 N N . ARG B 1 85 ? 22.780 -1.397 -12.730 1.00 15.72 ? 154 ARG B N 1 ATOM 3652 C CA . ARG B 1 85 ? 22.317 -2.575 -12.023 1.00 16.01 ? 154 ARG B CA 1 ATOM 3653 C C . ARG B 1 85 ? 21.991 -2.229 -10.546 1.00 16.16 ? 154 ARG B C 1 ATOM 3654 O O . ARG B 1 85 ? 22.758 -1.508 -9.855 1.00 15.09 ? 154 ARG B O 1 ATOM 3655 C CB . ARG B 1 85 ? 23.374 -3.675 -12.136 1.00 15.47 ? 154 ARG B CB 1 ATOM 3656 C CG . ARG B 1 85 ? 22.821 -5.067 -12.017 1.00 18.44 ? 154 ARG B CG 1 ATOM 3657 C CD . ARG B 1 85 ? 22.624 -5.793 -13.354 1.00 18.70 ? 154 ARG B CD 1 ATOM 3658 N NE . ARG B 1 85 ? 21.749 -6.946 -13.143 1.00 19.58 ? 154 ARG B NE 1 ATOM 3659 C CZ . ARG B 1 85 ? 22.135 -8.211 -12.989 1.00 22.41 ? 154 ARG B CZ 1 ATOM 3660 N NH1 . ARG B 1 85 ? 23.415 -8.578 -13.062 1.00 23.92 ? 154 ARG B NH1 1 ATOM 3661 N NH2 . ARG B 1 85 ? 21.217 -9.139 -12.780 1.00 22.86 ? 154 ARG B NH2 1 ATOM 3662 N N . HIS B 1 86 ? 20.838 -2.734 -10.094 1.00 16.31 ? 155 HIS B N 1 ATOM 3663 C CA . HIS B 1 86 ? 20.312 -2.446 -8.761 1.00 16.39 ? 155 HIS B CA 1 ATOM 3664 C C . HIS B 1 86 ? 19.705 -3.639 -8.085 1.00 15.74 ? 155 HIS B C 1 ATOM 3665 O O . HIS B 1 86 ? 19.105 -4.463 -8.746 1.00 14.54 ? 155 HIS B O 1 ATOM 3666 C CB . HIS B 1 86 ? 19.201 -1.421 -8.852 1.00 17.07 ? 155 HIS B CB 1 ATOM 3667 C CG . HIS B 1 86 ? 19.666 -0.011 -8.733 1.00 18.93 ? 155 HIS B CG 1 ATOM 3668 N ND1 . HIS B 1 86 ? 20.493 0.576 -9.659 1.00 19.20 ? 155 HIS B ND1 1 ATOM 3669 C CD2 . HIS B 1 86 ? 19.385 0.941 -7.815 1.00 21.05 ? 155 HIS B CD2 1 ATOM 3670 C CE1 . HIS B 1 86 ? 20.697 1.834 -9.326 1.00 18.51 ? 155 HIS B CE1 1 ATOM 3671 N NE2 . HIS B 1 86 ? 20.045 2.078 -8.203 1.00 20.81 ? 155 HIS B NE2 1 ATOM 3672 N N . LEU B 1 87 ? 19.831 -3.654 -6.751 1.00 15.32 ? 156 LEU B N 1 ATOM 3673 C CA . LEU B 1 87 ? 19.120 -4.557 -5.867 1.00 14.66 ? 156 LEU B CA 1 ATOM 3674 C C . LEU B 1 87 ? 17.711 -4.017 -5.645 1.00 14.56 ? 156 LEU B C 1 ATOM 3675 O O . LEU B 1 87 ? 17.543 -2.873 -5.210 1.00 14.53 ? 156 LEU B O 1 ATOM 3676 C CB . LEU B 1 87 ? 19.842 -4.661 -4.528 1.00 14.76 ? 156 LEU B CB 1 ATOM 3677 C CG . LEU B 1 87 ? 19.261 -5.638 -3.504 1.00 15.16 ? 156 LEU B CG 1 ATOM 3678 C CD1 . LEU B 1 87 ? 19.362 -7.096 -4.010 1.00 13.62 ? 156 LEU B CD1 1 ATOM 3679 C CD2 . LEU B 1 87 ? 19.948 -5.458 -2.113 1.00 13.33 ? 156 LEU B CD2 1 ATOM 3680 N N . ILE B 1 88 ? 16.716 -4.860 -5.935 1.00 13.82 ? 157 ILE B N 1 ATOM 3681 C CA . ILE B 1 88 ? 15.307 -4.521 -5.861 1.00 13.82 ? 157 ILE B CA 1 ATOM 3682 C C . ILE B 1 88 ? 14.590 -5.612 -5.074 1.00 14.81 ? 157 ILE B C 1 ATOM 3683 O O . ILE B 1 88 ? 15.113 -6.729 -4.924 1.00 14.72 ? 157 ILE B O 1 ATOM 3684 C CB . ILE B 1 88 ? 14.631 -4.371 -7.301 1.00 14.09 ? 157 ILE B CB 1 ATOM 3685 C CG1 . ILE B 1 88 ? 14.630 -5.682 -8.093 1.00 11.51 ? 157 ILE B CG1 1 ATOM 3686 C CG2 . ILE B 1 88 ? 15.299 -3.282 -8.131 1.00 12.32 ? 157 ILE B CG2 1 ATOM 3687 C CD1 . ILE B 1 88 ? 13.356 -6.413 -8.013 1.00 11.87 ? 157 ILE B CD1 1 ATOM 3688 N N . SER B 1 89 ? 13.417 -5.281 -4.537 1.00 14.96 ? 158 SER B N 1 ATOM 3689 C CA . SER B 1 89 ? 12.623 -6.269 -3.817 1.00 15.44 ? 158 SER B CA 1 ATOM 3690 C C . SER B 1 89 ? 11.143 -6.005 -3.980 1.00 15.90 ? 158 SER B C 1 ATOM 3691 O O . SER B 1 89 ? 10.744 -4.928 -4.402 1.00 16.12 ? 158 SER B O 1 ATOM 3692 C CB . SER B 1 89 ? 13.016 -6.375 -2.312 1.00 15.06 ? 158 SER B CB 1 ATOM 3693 O OG . SER B 1 89 ? 12.538 -5.303 -1.521 1.00 13.25 ? 158 SER B OG 1 ATOM 3694 N N . VAL B 1 90 ? 10.363 -7.053 -3.730 1.00 16.36 ? 159 VAL B N 1 ATOM 3695 C CA . VAL B 1 90 ? 8.910 -6.991 -3.631 1.00 17.04 ? 159 VAL B CA 1 ATOM 3696 C C . VAL B 1 90 ? 8.595 -7.864 -2.412 1.00 17.80 ? 159 VAL B C 1 ATOM 3697 O O . VAL B 1 90 ? 9.374 -8.737 -2.057 1.00 17.91 ? 159 VAL B O 1 ATOM 3698 C CB . VAL B 1 90 ? 8.177 -7.551 -4.906 1.00 16.93 ? 159 VAL B CB 1 ATOM 3699 C CG1 . VAL B 1 90 ? 8.202 -6.551 -6.055 1.00 17.91 ? 159 VAL B CG1 1 ATOM 3700 C CG2 . VAL B 1 90 ? 8.764 -8.860 -5.368 1.00 16.48 ? 159 VAL B CG2 1 ATOM 3701 N N . LYS B 1 91 ? 7.479 -7.635 -1.747 1.00 18.68 ? 160 LYS B N 1 ATOM 3702 C CA . LYS B 1 91 ? 6.990 -8.643 -0.829 1.00 19.47 ? 160 LYS B CA 1 ATOM 3703 C C . LYS B 1 91 ? 6.752 -9.921 -1.646 1.00 19.27 ? 160 LYS B C 1 ATOM 3704 O O . LYS B 1 91 ? 6.144 -9.874 -2.724 1.00 19.27 ? 160 LYS B O 1 ATOM 3705 C CB . LYS B 1 91 ? 5.706 -8.175 -0.165 1.00 19.60 ? 160 LYS B CB 1 ATOM 3706 C CG . LYS B 1 91 ? 5.018 -9.195 0.713 1.00 21.76 ? 160 LYS B CG 1 ATOM 3707 C CD . LYS B 1 91 ? 3.483 -8.933 0.678 1.00 25.90 ? 160 LYS B CD 1 ATOM 3708 C CE . LYS B 1 91 ? 2.727 -9.637 1.792 1.00 27.40 ? 160 LYS B CE 1 ATOM 3709 N NZ . LYS B 1 91 ? 3.363 -9.361 3.115 1.00 29.25 ? 160 LYS B NZ 1 ATOM 3710 N N . LEU B 1 92 ? 7.241 -11.052 -1.130 1.00 18.86 ? 161 LEU B N 1 ATOM 3711 C CA . LEU B 1 92 ? 7.026 -12.347 -1.761 1.00 18.23 ? 161 LEU B CA 1 ATOM 3712 C C . LEU B 1 92 ? 5.545 -12.616 -2.008 1.00 18.40 ? 161 LEU B C 1 ATOM 3713 O O . LEU B 1 92 ? 4.710 -12.550 -1.089 1.00 17.43 ? 161 LEU B O 1 ATOM 3714 C CB . LEU B 1 92 ? 7.628 -13.462 -0.915 1.00 18.91 ? 161 LEU B CB 1 ATOM 3715 C CG . LEU B 1 92 ? 7.589 -14.901 -1.435 1.00 18.27 ? 161 LEU B CG 1 ATOM 3716 C CD1 . LEU B 1 92 ? 8.268 -15.007 -2.803 1.00 16.04 ? 161 LEU B CD1 1 ATOM 3717 C CD2 . LEU B 1 92 ? 8.237 -15.828 -0.376 1.00 13.90 ? 161 LEU B CD2 1 ATOM 3718 N N . GLY B 1 93 ? 5.243 -12.920 -3.276 1.00 18.13 ? 162 GLY B N 1 ATOM 3719 C CA . GLY B 1 93 ? 3.898 -13.114 -3.746 1.00 17.50 ? 162 GLY B CA 1 ATOM 3720 C C . GLY B 1 93 ? 3.482 -12.028 -4.704 1.00 17.35 ? 162 GLY B C 1 ATOM 3721 O O . GLY B 1 93 ? 2.455 -12.140 -5.343 1.00 17.25 ? 162 GLY B O 1 ATOM 3722 N N . LYS B 1 94 ? 4.256 -10.955 -4.792 1.00 17.64 ? 163 LYS B N 1 ATOM 3723 C CA . LYS B 1 94 ? 3.935 -9.884 -5.710 1.00 17.70 ? 163 LYS B CA 1 ATOM 3724 C C . LYS B 1 94 ? 4.847 -9.997 -6.900 1.00 17.20 ? 163 LYS B C 1 ATOM 3725 O O . LYS B 1 94 ? 5.996 -10.384 -6.757 1.00 17.20 ? 163 LYS B O 1 ATOM 3726 C CB . LYS B 1 94 ? 4.095 -8.528 -5.040 1.00 18.42 ? 163 LYS B CB 1 ATOM 3727 C CG . LYS B 1 94 ? 3.165 -8.296 -3.852 1.00 19.35 ? 163 LYS B CG 1 ATOM 3728 C CD . LYS B 1 94 ? 1.686 -8.147 -4.242 1.00 19.18 ? 163 LYS B CD 1 ATOM 3729 C CE . LYS B 1 94 ? 1.372 -6.768 -4.802 1.00 20.55 ? 163 LYS B CE 1 ATOM 3730 N NZ . LYS B 1 94 ? -0.114 -6.468 -4.932 1.00 17.97 ? 163 LYS B NZ 1 ATOM 3731 N N . ILE B 1 95 ? 4.316 -9.666 -8.072 1.00 16.74 ? 164 ILE B N 1 ATOM 3732 C CA . ILE B 1 95 ? 5.090 -9.630 -9.310 1.00 16.49 ? 164 ILE B CA 1 ATOM 3733 C C . ILE B 1 95 ? 6.036 -8.412 -9.290 1.00 16.05 ? 164 ILE B C 1 ATOM 3734 O O . ILE B 1 95 ? 5.586 -7.284 -9.107 1.00 16.11 ? 164 ILE B O 1 ATOM 3735 C CB . ILE B 1 95 ? 4.161 -9.538 -10.538 1.00 16.30 ? 164 ILE B CB 1 ATOM 3736 C CG1 . ILE B 1 95 ? 3.094 -10.656 -10.526 1.00 16.48 ? 164 ILE B CG1 1 ATOM 3737 C CG2 . ILE B 1 95 ? 4.963 -9.535 -11.835 1.00 15.89 ? 164 ILE B CG2 1 ATOM 3738 C CD1 . ILE B 1 95 ? 3.608 -12.067 -10.494 1.00 14.47 ? 164 ILE B CD1 1 ATOM 3739 N N . PRO B 1 96 ? 7.351 -8.631 -9.460 1.00 16.29 ? 165 PRO B N 1 ATOM 3740 C CA . PRO B 1 96 ? 8.298 -7.493 -9.478 1.00 16.38 ? 165 PRO B CA 1 ATOM 3741 C C . PRO B 1 96 ? 8.274 -6.680 -10.784 1.00 16.58 ? 165 PRO B C 1 ATOM 3742 O O . PRO B 1 96 ? 8.909 -7.040 -11.773 1.00 16.14 ? 165 PRO B O 1 ATOM 3743 C CB . PRO B 1 96 ? 9.663 -8.153 -9.247 1.00 16.54 ? 165 PRO B CB 1 ATOM 3744 C CG . PRO B 1 96 ? 9.472 -9.611 -9.584 1.00 16.70 ? 165 PRO B CG 1 ATOM 3745 C CD . PRO B 1 96 ? 8.017 -9.925 -9.687 1.00 16.03 ? 165 PRO B CD 1 ATOM 3746 N N . THR B 1 97 ? 7.513 -5.591 -10.757 1.00 16.92 ? 166 THR B N 1 ATOM 3747 C CA . THR B 1 97 ? 7.288 -4.733 -11.914 1.00 17.14 ? 166 THR B CA 1 ATOM 3748 C C . THR B 1 97 ? 7.884 -3.376 -11.581 1.00 17.35 ? 166 THR B C 1 ATOM 3749 O O . THR B 1 97 ? 8.187 -3.078 -10.417 1.00 18.10 ? 166 THR B O 1 ATOM 3750 C CB . THR B 1 97 ? 5.789 -4.447 -12.180 1.00 16.90 ? 166 THR B CB 1 ATOM 3751 O OG1 . THR B 1 97 ? 5.150 -4.103 -10.946 1.00 16.07 ? 166 THR B OG1 1 ATOM 3752 C CG2 . THR B 1 97 ? 5.077 -5.622 -12.808 1.00 17.92 ? 166 THR B CG2 1 ATOM 3753 N N . VAL B 1 98 ? 7.983 -2.549 -12.606 1.00 17.17 ? 167 VAL B N 1 ATOM 3754 C CA . VAL B 1 98 ? 8.407 -1.160 -12.472 1.00 17.32 ? 167 VAL B CA 1 ATOM 3755 C C . VAL B 1 98 ? 7.780 -0.540 -11.222 1.00 17.81 ? 167 VAL B C 1 ATOM 3756 O O . VAL B 1 98 ? 8.467 0.061 -10.390 1.00 17.32 ? 167 VAL B O 1 ATOM 3757 C CB . VAL B 1 98 ? 8.017 -0.358 -13.748 1.00 16.87 ? 167 VAL B CB 1 ATOM 3758 C CG1 . VAL B 1 98 ? 8.263 1.103 -13.570 1.00 16.90 ? 167 VAL B CG1 1 ATOM 3759 C CG2 . VAL B 1 98 ? 8.782 -0.895 -14.977 1.00 16.24 ? 167 VAL B CG2 1 ATOM 3760 N N . GLU B 1 99 ? 6.473 -0.730 -11.083 1.00 17.94 ? 168 GLU B N 1 ATOM 3761 C CA . GLU B 1 99 ? 5.740 -0.082 -10.011 1.00 18.48 ? 168 GLU B CA 1 ATOM 3762 C C . GLU B 1 99 ? 5.665 -0.821 -8.671 1.00 17.34 ? 168 GLU B C 1 ATOM 3763 O O . GLU B 1 99 ? 5.681 -0.197 -7.635 1.00 16.98 ? 168 GLU B O 1 ATOM 3764 C CB . GLU B 1 99 ? 4.348 0.301 -10.486 1.00 18.97 ? 168 GLU B CB 1 ATOM 3765 C CG . GLU B 1 99 ? 4.335 1.741 -10.887 1.00 22.07 ? 168 GLU B CG 1 ATOM 3766 C CD . GLU B 1 99 ? 3.105 2.106 -11.588 1.00 25.31 ? 168 GLU B CD 1 ATOM 3767 O OE1 . GLU B 1 99 ? 2.041 1.640 -11.136 1.00 31.73 ? 168 GLU B OE1 1 ATOM 3768 O OE2 . GLU B 1 99 ? 3.195 2.850 -12.577 1.00 27.70 ? 168 GLU B OE2 1 ATOM 3769 N N . ASN B 1 100 ? 5.605 -2.145 -8.696 1.00 16.93 ? 169 ASN B N 1 ATOM 3770 C CA . ASN B 1 100 ? 5.513 -2.907 -7.446 1.00 16.52 ? 169 ASN B CA 1 ATOM 3771 C C . ASN B 1 100 ? 6.804 -2.876 -6.631 1.00 16.41 ? 169 ASN B C 1 ATOM 3772 O O . ASN B 1 100 ? 6.779 -2.920 -5.397 1.00 15.92 ? 169 ASN B O 1 ATOM 3773 C CB . ASN B 1 100 ? 5.128 -4.352 -7.736 1.00 15.58 ? 169 ASN B CB 1 ATOM 3774 C CG . ASN B 1 100 ? 3.665 -4.572 -7.680 1.00 16.26 ? 169 ASN B CG 1 ATOM 3775 O OD1 . ASN B 1 100 ? 2.898 -3.698 -7.256 1.00 16.97 ? 169 ASN B OD1 1 ATOM 3776 N ND2 . ASN B 1 100 ? 3.234 -5.754 -8.125 1.00 18.43 ? 169 ASN B ND2 1 ATOM 3777 N N . SER B 1 101 ? 7.913 -2.794 -7.352 1.00 16.29 ? 170 SER B N 1 ATOM 3778 C CA . SER B 1 101 ? 9.235 -2.947 -6.793 1.00 16.90 ? 170 SER B CA 1 ATOM 3779 C C . SER B 1 101 ? 9.701 -1.689 -6.103 1.00 16.84 ? 170 SER B C 1 ATOM 3780 O O . SER B 1 101 ? 9.184 -0.598 -6.357 1.00 16.84 ? 170 SER B O 1 ATOM 3781 C CB . SER B 1 101 ? 10.248 -3.293 -7.905 1.00 17.48 ? 170 SER B CB 1 ATOM 3782 O OG . SER B 1 101 ? 10.015 -4.581 -8.426 1.00 18.32 ? 170 SER B OG 1 ATOM 3783 N N . ILE B 1 102 ? 10.684 -1.857 -5.225 1.00 16.61 ? 171 ILE B N 1 ATOM 3784 C CA . ILE B 1 102 ? 11.337 -0.721 -4.594 1.00 16.77 ? 171 ILE B CA 1 ATOM 3785 C C . ILE B 1 102 ? 12.807 -0.955 -4.862 1.00 16.22 ? 171 ILE B C 1 ATOM 3786 O O . ILE B 1 102 ? 13.265 -2.104 -4.849 1.00 17.01 ? 171 ILE B O 1 ATOM 3787 C CB . ILE B 1 102 ? 10.954 -0.580 -3.049 1.00 16.99 ? 171 ILE B CB 1 ATOM 3788 C CG1 . ILE B 1 102 ? 11.345 0.804 -2.508 1.00 17.08 ? 171 ILE B CG1 1 ATOM 3789 C CG2 . ILE B 1 102 ? 11.504 -1.729 -2.204 1.00 16.14 ? 171 ILE B CG2 1 ATOM 3790 C CD1 . ILE B 1 102 ? 11.395 0.897 -0.957 1.00 17.43 ? 171 ILE B CD1 1 ATOM 3791 N N . PHE B 1 103 ? 13.529 0.114 -5.161 1.00 15.38 ? 172 PHE B N 1 ATOM 3792 C CA . PHE B 1 103 ? 14.934 0.019 -5.492 1.00 15.02 ? 172 PHE B CA 1 ATOM 3793 C C . PHE B 1 103 ? 15.704 0.357 -4.218 1.00 15.16 ? 172 PHE B C 1 ATOM 3794 O O . PHE B 1 103 ? 15.541 1.444 -3.676 1.00 13.59 ? 172 PHE B O 1 ATOM 3795 C CB . PHE B 1 103 ? 15.289 0.963 -6.632 1.00 13.99 ? 172 PHE B CB 1 ATOM 3796 C CG . PHE B 1 103 ? 14.653 0.591 -7.956 1.00 13.64 ? 172 PHE B CG 1 ATOM 3797 C CD1 . PHE B 1 103 ? 15.434 0.375 -9.080 1.00 12.64 ? 172 PHE B CD1 1 ATOM 3798 C CD2 . PHE B 1 103 ? 13.278 0.416 -8.077 1.00 12.26 ? 172 PHE B CD2 1 ATOM 3799 C CE1 . PHE B 1 103 ? 14.866 0.037 -10.302 1.00 13.33 ? 172 PHE B CE1 1 ATOM 3800 C CE2 . PHE B 1 103 ? 12.723 0.063 -9.302 1.00 13.34 ? 172 PHE B CE2 1 ATOM 3801 C CZ . PHE B 1 103 ? 13.522 -0.099 -10.413 1.00 12.75 ? 172 PHE B CZ 1 ATOM 3802 N N . HIS B 1 104 ? 16.554 -0.572 -3.768 1.00 16.22 ? 173 HIS B N 1 ATOM 3803 C CA . HIS B 1 104 ? 17.322 -0.406 -2.500 1.00 16.92 ? 173 HIS B CA 1 ATOM 3804 C C . HIS B 1 104 ? 18.655 0.297 -2.666 1.00 18.01 ? 173 HIS B C 1 ATOM 3805 O O . HIS B 1 104 ? 19.013 1.185 -1.862 1.00 17.72 ? 173 HIS B O 1 ATOM 3806 C CB . HIS B 1 104 ? 17.573 -1.763 -1.848 1.00 16.72 ? 173 HIS B CB 1 ATOM 3807 C CG . HIS B 1 104 ? 16.324 -2.426 -1.380 1.00 17.01 ? 173 HIS B CG 1 ATOM 3808 N ND1 . HIS B 1 104 ? 15.473 -1.828 -0.488 1.00 19.73 ? 173 HIS B ND1 1 ATOM 3809 C CD2 . HIS B 1 104 ? 15.755 -3.609 -1.706 1.00 19.84 ? 173 HIS B CD2 1 ATOM 3810 C CE1 . HIS B 1 104 ? 14.440 -2.621 -0.263 1.00 20.72 ? 173 HIS B CE1 1 ATOM 3811 N NE2 . HIS B 1 104 ? 14.574 -3.700 -1.010 1.00 19.33 ? 173 HIS B NE2 1 ATOM 3812 N N . MET B 1 105 ? 19.413 -0.126 -3.679 1.00 18.39 ? 174 MET B N 1 ATOM 3813 C CA . MET B 1 105 ? 20.714 0.457 -3.908 1.00 19.42 ? 174 MET B CA 1 ATOM 3814 C C . MET B 1 105 ? 21.339 -0.050 -5.202 1.00 19.38 ? 174 MET B C 1 ATOM 3815 O O . MET B 1 105 ? 20.963 -1.101 -5.732 1.00 19.99 ? 174 MET B O 1 ATOM 3816 C CB . MET B 1 105 ? 21.659 0.183 -2.711 1.00 19.90 ? 174 MET B CB 1 ATOM 3817 C CG . MET B 1 105 ? 22.130 -1.251 -2.567 1.00 21.48 ? 174 MET B CG 1 ATOM 3818 S SD . MET B 1 105 ? 23.527 -1.363 -1.435 1.00 26.51 ? 174 MET B SD 1 ATOM 3819 C CE . MET B 1 105 ? 22.646 -1.785 0.081 1.00 21.24 ? 174 MET B CE 1 ATOM 3820 N N . ALA B 1 106 ? 22.307 0.702 -5.702 1.00 19.35 ? 175 ALA B N 1 ATOM 3821 C CA . ALA B 1 106 ? 23.045 0.300 -6.900 1.00 18.98 ? 175 ALA B CA 1 ATOM 3822 C C . ALA B 1 106 ? 23.875 -0.905 -6.512 1.00 18.48 ? 175 ALA B C 1 ATOM 3823 O O . ALA B 1 106 ? 24.623 -0.857 -5.534 1.00 19.36 ? 175 ALA B O 1 ATOM 3824 C CB . ALA B 1 106 ? 23.933 1.442 -7.401 1.00 18.47 ? 175 ALA B CB 1 ATOM 3825 N N . ALA B 1 107 ? 23.677 -2.008 -7.215 1.00 17.63 ? 176 ALA B N 1 ATOM 3826 C CA . ALA B 1 107 ? 24.458 -3.216 -6.973 1.00 17.00 ? 176 ALA B CA 1 ATOM 3827 C C . ALA B 1 107 ? 24.437 -4.117 -8.218 1.00 16.84 ? 176 ALA B C 1 ATOM 3828 O O . ALA B 1 107 ? 23.424 -4.203 -8.908 1.00 16.41 ? 176 ALA B O 1 ATOM 3829 C CB . ALA B 1 107 ? 23.927 -3.967 -5.766 1.00 16.08 ? 176 ALA B CB 1 ATOM 3830 N N . TRP B 1 108 ? 25.567 -4.759 -8.501 1.00 16.54 ? 177 TRP B N 1 ATOM 3831 C CA . TRP B 1 108 ? 25.565 -5.900 -9.423 1.00 16.79 ? 177 TRP B CA 1 ATOM 3832 C C . TRP B 1 108 ? 25.867 -7.198 -8.674 1.00 16.83 ? 177 TRP B C 1 ATOM 3833 O O . TRP B 1 108 ? 26.078 -8.226 -9.298 1.00 16.44 ? 177 TRP B O 1 ATOM 3834 C CB . TRP B 1 108 ? 26.498 -5.670 -10.641 1.00 16.32 ? 177 TRP B CB 1 ATOM 3835 C CG . TRP B 1 108 ? 27.784 -4.954 -10.383 1.00 15.11 ? 177 TRP B CG 1 ATOM 3836 C CD1 . TRP B 1 108 ? 28.094 -3.685 -10.751 1.00 16.82 ? 177 TRP B CD1 1 ATOM 3837 C CD2 . TRP B 1 108 ? 28.945 -5.473 -9.717 1.00 13.72 ? 177 TRP B CD2 1 ATOM 3838 N NE1 . TRP B 1 108 ? 29.361 -3.373 -10.338 1.00 15.91 ? 177 TRP B NE1 1 ATOM 3839 C CE2 . TRP B 1 108 ? 29.908 -4.463 -9.717 1.00 14.11 ? 177 TRP B CE2 1 ATOM 3840 C CE3 . TRP B 1 108 ? 29.256 -6.699 -9.122 1.00 13.85 ? 177 TRP B CE3 1 ATOM 3841 C CZ2 . TRP B 1 108 ? 31.172 -4.642 -9.167 1.00 15.05 ? 177 TRP B CZ2 1 ATOM 3842 C CZ3 . TRP B 1 108 ? 30.501 -6.876 -8.563 1.00 12.82 ? 177 TRP B CZ3 1 ATOM 3843 C CH2 . TRP B 1 108 ? 31.444 -5.855 -8.591 1.00 14.27 ? 177 TRP B CH2 1 ATOM 3844 N N . SER B 1 109 ? 25.864 -7.131 -7.327 1.00 17.27 ? 178 SER B N 1 ATOM 3845 C CA . SER B 1 109 ? 25.997 -8.309 -6.468 1.00 16.65 ? 178 SER B CA 1 ATOM 3846 C C . SER B 1 109 ? 25.308 -8.062 -5.136 1.00 16.60 ? 178 SER B C 1 ATOM 3847 O O . SER B 1 109 ? 25.473 -6.999 -4.493 1.00 17.08 ? 178 SER B O 1 ATOM 3848 C CB . SER B 1 109 ? 27.466 -8.699 -6.258 1.00 17.12 ? 178 SER B CB 1 ATOM 3849 O OG . SER B 1 109 ? 27.597 -9.939 -5.545 1.00 16.82 ? 178 SER B OG 1 ATOM 3850 N N . GLY B 1 110 ? 24.523 -9.046 -4.721 1.00 16.00 ? 179 GLY B N 1 ATOM 3851 C CA . GLY B 1 110 ? 23.516 -8.836 -3.677 1.00 16.15 ? 179 GLY B CA 1 ATOM 3852 C C . GLY B 1 110 ? 23.453 -9.782 -2.482 1.00 15.67 ? 179 GLY B C 1 ATOM 3853 O O . GLY B 1 110 ? 23.853 -10.939 -2.544 1.00 14.53 ? 179 GLY B O 1 ATOM 3854 N N . SER B 1 111 ? 22.949 -9.243 -1.375 1.00 16.48 ? 180 SER B N 1 ATOM 3855 C CA . SER B 1 111 ? 22.484 -10.036 -0.223 1.00 16.15 ? 180 SER B CA 1 ATOM 3856 C C . SER B 1 111 ? 21.567 -9.176 0.637 1.00 16.71 ? 180 SER B C 1 ATOM 3857 O O . SER B 1 111 ? 21.595 -7.931 0.562 1.00 16.52 ? 180 SER B O 1 ATOM 3858 C CB . SER B 1 111 ? 23.638 -10.587 0.619 1.00 16.05 ? 180 SER B CB 1 ATOM 3859 O OG . SER B 1 111 ? 23.152 -11.509 1.588 1.00 14.63 ? 180 SER B OG 1 ATOM 3860 N N . ALA B 1 112 ? 20.723 -9.834 1.436 1.00 17.29 ? 181 ALA B N 1 ATOM 3861 C CA . ALA B 1 112 ? 19.854 -9.118 2.366 1.00 17.20 ? 181 ALA B CA 1 ATOM 3862 C C . ALA B 1 112 ? 19.430 -10.063 3.479 1.00 17.83 ? 181 ALA B C 1 ATOM 3863 O O . ALA B 1 112 ? 19.418 -11.279 3.256 1.00 16.54 ? 181 ALA B O 1 ATOM 3864 C CB . ALA B 1 112 ? 18.650 -8.582 1.654 1.00 16.89 ? 181 ALA B CB 1 ATOM 3865 N N . CYS B 1 113 ? 19.112 -9.501 4.659 1.00 17.49 ? 182 CYS B N 1 ATOM 3866 C CA . CYS B 1 113 ? 18.634 -10.297 5.816 1.00 18.20 ? 182 CYS B CA 1 ATOM 3867 C C . CYS B 1 113 ? 18.100 -9.467 7.026 1.00 17.66 ? 182 CYS B C 1 ATOM 3868 O O . CYS B 1 113 ? 18.547 -8.344 7.270 1.00 16.79 ? 182 CYS B O 1 ATOM 3869 C CB . CYS B 1 113 ? 19.726 -11.251 6.312 1.00 18.06 ? 182 CYS B CB 1 ATOM 3870 S SG . CYS B 1 113 ? 21.283 -10.452 6.777 1.00 21.19 ? 182 CYS B SG 1 ATOM 3871 N N . HIS B 1 114 ? 17.145 -10.057 7.748 1.00 17.11 ? 183 HIS B N 1 ATOM 3872 C CA . HIS B 1 114 ? 16.470 -9.436 8.887 1.00 17.48 ? 183 HIS B CA 1 ATOM 3873 C C . HIS B 1 114 ? 16.961 -10.083 10.169 1.00 17.23 ? 183 HIS B C 1 ATOM 3874 O O . HIS B 1 114 ? 17.041 -11.307 10.245 1.00 17.59 ? 183 HIS B O 1 ATOM 3875 C CB . HIS B 1 114 ? 14.950 -9.663 8.770 1.00 17.56 ? 183 HIS B CB 1 ATOM 3876 C CG . HIS B 1 114 ? 14.126 -8.794 9.663 1.00 16.97 ? 183 HIS B CG 1 ATOM 3877 N ND1 . HIS B 1 114 ? 13.360 -7.747 9.186 1.00 17.39 ? 183 HIS B ND1 1 ATOM 3878 C CD2 . HIS B 1 114 ? 13.937 -8.823 11.007 1.00 16.28 ? 183 HIS B CD2 1 ATOM 3879 C CE1 . HIS B 1 114 ? 12.753 -7.161 10.212 1.00 19.57 ? 183 HIS B CE1 1 ATOM 3880 N NE2 . HIS B 1 114 ? 13.087 -7.794 11.327 1.00 14.03 ? 183 HIS B NE2 1 ATOM 3881 N N . ASP B 1 115 ? 17.236 -9.266 11.179 1.00 17.17 ? 184 ASP B N 1 ATOM 3882 C CA . ASP B 1 115 ? 17.792 -9.731 12.458 1.00 17.14 ? 184 ASP B CA 1 ATOM 3883 C C . ASP B 1 115 ? 16.786 -9.856 13.621 1.00 17.47 ? 184 ASP B C 1 ATOM 3884 O O . ASP B 1 115 ? 17.146 -10.226 14.748 1.00 17.42 ? 184 ASP B O 1 ATOM 3885 C CB . ASP B 1 115 ? 18.961 -8.824 12.863 1.00 16.84 ? 184 ASP B CB 1 ATOM 3886 C CG . ASP B 1 115 ? 18.571 -7.339 12.991 1.00 17.33 ? 184 ASP B CG 1 ATOM 3887 O OD1 . ASP B 1 115 ? 17.382 -7.025 13.118 1.00 17.50 ? 184 ASP B OD1 1 ATOM 3888 O OD2 . ASP B 1 115 ? 19.477 -6.475 12.999 1.00 18.23 ? 184 ASP B OD2 1 ATOM 3889 N N . GLY B 1 116 ? 15.533 -9.528 13.352 1.00 17.67 ? 185 GLY B N 1 ATOM 3890 C CA . GLY B 1 116 ? 14.485 -9.466 14.388 1.00 17.46 ? 185 GLY B CA 1 ATOM 3891 C C . GLY B 1 116 ? 13.944 -8.068 14.521 1.00 17.63 ? 185 GLY B C 1 ATOM 3892 O O . GLY B 1 116 ? 12.780 -7.893 14.844 1.00 17.71 ? 185 GLY B O 1 ATOM 3893 N N . LYS B 1 117 ? 14.786 -7.067 14.251 1.00 18.15 ? 186 LYS B N 1 ATOM 3894 C CA . LYS B 1 117 ? 14.389 -5.648 14.323 1.00 18.61 ? 186 LYS B CA 1 ATOM 3895 C C . LYS B 1 117 ? 14.298 -4.950 12.962 1.00 18.82 ? 186 LYS B C 1 ATOM 3896 O O . LYS B 1 117 ? 13.376 -4.162 12.721 1.00 18.22 ? 186 LYS B O 1 ATOM 3897 C CB . LYS B 1 117 ? 15.372 -4.862 15.178 1.00 18.73 ? 186 LYS B CB 1 ATOM 3898 C CG . LYS B 1 117 ? 15.690 -5.563 16.463 1.00 19.20 ? 186 LYS B CG 1 ATOM 3899 C CD . LYS B 1 117 ? 16.086 -4.635 17.571 1.00 20.40 ? 186 LYS B CD 1 ATOM 3900 C CE . LYS B 1 117 ? 15.770 -5.300 18.927 1.00 20.56 ? 186 LYS B CE 1 ATOM 3901 N NZ . LYS B 1 117 ? 16.618 -4.785 19.985 1.00 21.97 ? 186 LYS B NZ 1 ATOM 3902 N N . GLU B 1 118 ? 15.247 -5.236 12.077 1.00 18.66 ? 187 GLU B N 1 ATOM 3903 C CA . GLU B 1 118 ? 15.387 -4.450 10.896 1.00 18.29 ? 187 GLU B CA 1 ATOM 3904 C C . GLU B 1 118 ? 16.068 -5.241 9.770 1.00 18.13 ? 187 GLU B C 1 ATOM 3905 O O . GLU B 1 118 ? 16.766 -6.240 9.993 1.00 18.15 ? 187 GLU B O 1 ATOM 3906 C CB . GLU B 1 118 ? 16.165 -3.182 11.305 1.00 18.81 ? 187 GLU B CB 1 ATOM 3907 C CG . GLU B 1 118 ? 16.282 -2.065 10.287 1.00 19.40 ? 187 GLU B CG 1 ATOM 3908 C CD . GLU B 1 118 ? 14.952 -1.561 9.798 1.00 21.61 ? 187 GLU B CD 1 ATOM 3909 O OE1 . GLU B 1 118 ? 14.607 -0.381 10.110 1.00 23.46 ? 187 GLU B OE1 1 ATOM 3910 O OE2 . GLU B 1 118 ? 14.244 -2.350 9.124 1.00 20.52 ? 187 GLU B OE2 1 ATOM 3911 N N . TRP B 1 119 ? 15.828 -4.810 8.543 1.00 17.92 ? 188 TRP B N 1 ATOM 3912 C CA . TRP B 1 119 ? 16.501 -5.399 7.390 1.00 17.48 ? 188 TRP B CA 1 ATOM 3913 C C . TRP B 1 119 ? 17.907 -4.831 7.310 1.00 17.68 ? 188 TRP B C 1 ATOM 3914 O O . TRP B 1 119 ? 18.107 -3.641 7.570 1.00 18.28 ? 188 TRP B O 1 ATOM 3915 C CB . TRP B 1 119 ? 15.745 -5.082 6.108 1.00 16.69 ? 188 TRP B CB 1 ATOM 3916 C CG . TRP B 1 119 ? 14.511 -5.892 5.965 1.00 17.15 ? 188 TRP B CG 1 ATOM 3917 C CD1 . TRP B 1 119 ? 13.229 -5.526 6.282 1.00 16.82 ? 188 TRP B CD1 1 ATOM 3918 C CD2 . TRP B 1 119 ? 14.432 -7.229 5.462 1.00 16.67 ? 188 TRP B CD2 1 ATOM 3919 N NE1 . TRP B 1 119 ? 12.368 -6.557 6.011 1.00 16.80 ? 188 TRP B NE1 1 ATOM 3920 C CE2 . TRP B 1 119 ? 13.081 -7.613 5.511 1.00 15.90 ? 188 TRP B CE2 1 ATOM 3921 C CE3 . TRP B 1 119 ? 15.382 -8.136 4.965 1.00 17.02 ? 188 TRP B CE3 1 ATOM 3922 C CZ2 . TRP B 1 119 ? 12.643 -8.860 5.063 1.00 17.53 ? 188 TRP B CZ2 1 ATOM 3923 C CZ3 . TRP B 1 119 ? 14.953 -9.371 4.533 1.00 17.15 ? 188 TRP B CZ3 1 ATOM 3924 C CH2 . TRP B 1 119 ? 13.589 -9.728 4.595 1.00 16.60 ? 188 TRP B CH2 1 ATOM 3925 N N . THR B 1 120 ? 18.872 -5.694 7.007 1.00 17.17 ? 189 THR B N 1 ATOM 3926 C CA . THR B 1 120 ? 20.140 -5.278 6.451 1.00 17.18 ? 189 THR B CA 1 ATOM 3927 C C . THR B 1 120 ? 20.138 -5.609 4.928 1.00 17.12 ? 189 THR B C 1 ATOM 3928 O O . THR B 1 120 ? 19.783 -6.700 4.537 1.00 16.60 ? 189 THR B O 1 ATOM 3929 C CB . THR B 1 120 ? 21.273 -6.033 7.131 1.00 17.87 ? 189 THR B CB 1 ATOM 3930 O OG1 . THR B 1 120 ? 21.273 -5.746 8.551 1.00 16.74 ? 189 THR B OG1 1 ATOM 3931 C CG2 . THR B 1 120 ? 22.620 -5.684 6.473 1.00 16.14 ? 189 THR B CG2 1 ATOM 3932 N N . TYR B 1 121 ? 20.520 -4.648 4.096 1.00 17.59 ? 190 TYR B N 1 ATOM 3933 C CA . TYR B 1 121 ? 20.590 -4.807 2.637 1.00 17.50 ? 190 TYR B CA 1 ATOM 3934 C C . TYR B 1 121 ? 22.018 -4.610 2.175 1.00 17.96 ? 190 TYR B C 1 ATOM 3935 O O . TYR B 1 121 ? 22.685 -3.646 2.615 1.00 19.20 ? 190 TYR B O 1 ATOM 3936 C CB . TYR B 1 121 ? 19.755 -3.735 1.962 1.00 17.42 ? 190 TYR B CB 1 ATOM 3937 C CG . TYR B 1 121 ? 18.305 -3.655 2.401 1.00 16.36 ? 190 TYR B CG 1 ATOM 3938 C CD1 . TYR B 1 121 ? 17.365 -4.519 1.887 1.00 15.10 ? 190 TYR B CD1 1 ATOM 3939 C CD2 . TYR B 1 121 ? 17.879 -2.687 3.308 1.00 15.21 ? 190 TYR B CD2 1 ATOM 3940 C CE1 . TYR B 1 121 ? 16.050 -4.437 2.256 1.00 15.67 ? 190 TYR B CE1 1 ATOM 3941 C CE2 . TYR B 1 121 ? 16.541 -2.585 3.672 1.00 14.72 ? 190 TYR B CE2 1 ATOM 3942 C CZ . TYR B 1 121 ? 15.639 -3.472 3.152 1.00 14.65 ? 190 TYR B CZ 1 ATOM 3943 O OH . TYR B 1 121 ? 14.320 -3.426 3.510 1.00 13.55 ? 190 TYR B OH 1 ATOM 3944 N N . ILE B 1 122 ? 22.504 -5.496 1.301 1.00 17.54 ? 191 ILE B N 1 ATOM 3945 C CA . ILE B 1 122 ? 23.913 -5.461 0.886 1.00 17.40 ? 191 ILE B CA 1 ATOM 3946 C C . ILE B 1 122 ? 24.074 -5.495 -0.651 1.00 17.57 ? 191 ILE B C 1 ATOM 3947 O O . ILE B 1 122 ? 23.407 -6.260 -1.342 1.00 17.39 ? 191 ILE B O 1 ATOM 3948 C CB . ILE B 1 122 ? 24.719 -6.571 1.583 1.00 17.54 ? 191 ILE B CB 1 ATOM 3949 C CG1 . ILE B 1 122 ? 24.705 -6.349 3.122 1.00 19.33 ? 191 ILE B CG1 1 ATOM 3950 C CG2 . ILE B 1 122 ? 26.143 -6.571 1.095 1.00 16.89 ? 191 ILE B CG2 1 ATOM 3951 C CD1 . ILE B 1 122 ? 24.788 -7.594 3.919 1.00 20.09 ? 191 ILE B CD1 1 ATOM 3952 N N . GLY B 1 123 ? 24.945 -4.631 -1.165 1.00 17.42 ? 192 GLY B N 1 ATOM 3953 C CA . GLY B 1 123 ? 25.117 -4.466 -2.616 1.00 17.67 ? 192 GLY B CA 1 ATOM 3954 C C . GLY B 1 123 ? 26.536 -4.059 -2.955 1.00 17.39 ? 192 GLY B C 1 ATOM 3955 O O . GLY B 1 123 ? 27.062 -3.098 -2.388 1.00 17.56 ? 192 GLY B O 1 ATOM 3956 N N . VAL B 1 124 ? 27.170 -4.819 -3.843 1.00 17.83 ? 193 VAL B N 1 ATOM 3957 C CA . VAL B 1 124 ? 28.502 -4.492 -4.353 1.00 18.16 ? 193 VAL B CA 1 ATOM 3958 C C . VAL B 1 124 ? 28.322 -3.782 -5.676 1.00 18.54 ? 193 VAL B C 1 ATOM 3959 O O . VAL B 1 124 ? 27.614 -4.257 -6.558 1.00 18.65 ? 193 VAL B O 1 ATOM 3960 C CB . VAL B 1 124 ? 29.399 -5.776 -4.526 1.00 18.62 ? 193 VAL B CB 1 ATOM 3961 C CG1 . VAL B 1 124 ? 30.755 -5.468 -5.206 1.00 18.74 ? 193 VAL B CG1 1 ATOM 3962 C CG2 . VAL B 1 124 ? 29.623 -6.460 -3.177 1.00 17.16 ? 193 VAL B CG2 1 ATOM 3963 N N . ASP B 1 125 ? 28.957 -2.626 -5.822 1.00 19.53 ? 194 ASP B N 1 ATOM 3964 C CA . ASP B 1 125 ? 29.113 -2.044 -7.158 1.00 19.66 ? 194 ASP B CA 1 ATOM 3965 C C . ASP B 1 125 ? 30.538 -1.515 -7.340 1.00 20.37 ? 194 ASP B C 1 ATOM 3966 O O . ASP B 1 125 ? 31.436 -1.869 -6.554 1.00 20.77 ? 194 ASP B O 1 ATOM 3967 C CB . ASP B 1 125 ? 27.960 -1.056 -7.505 1.00 19.57 ? 194 ASP B CB 1 ATOM 3968 C CG . ASP B 1 125 ? 28.084 0.298 -6.859 1.00 19.42 ? 194 ASP B CG 1 ATOM 3969 O OD1 . ASP B 1 125 ? 28.890 0.482 -5.942 1.00 22.27 ? 194 ASP B OD1 1 ATOM 3970 O OD2 . ASP B 1 125 ? 27.340 1.202 -7.266 1.00 21.93 ? 194 ASP B OD2 1 ATOM 3971 N N . GLY B 1 126 ? 30.754 -0.713 -8.381 1.00 20.59 ? 195 GLY B N 1 ATOM 3972 C CA . GLY B 1 126 ? 32.082 -0.183 -8.682 1.00 21.45 ? 195 GLY B CA 1 ATOM 3973 C C . GLY B 1 126 ? 32.753 -0.861 -9.885 1.00 21.78 ? 195 GLY B C 1 ATOM 3974 O O . GLY B 1 126 ? 32.173 -1.775 -10.497 1.00 21.55 ? 195 GLY B O 1 ATOM 3975 N N . PRO B 1 127 ? 33.982 -0.409 -10.227 1.00 22.10 ? 196 PRO B N 1 ATOM 3976 C CA . PRO B 1 127 ? 34.750 -1.012 -11.313 1.00 22.30 ? 196 PRO B CA 1 ATOM 3977 C C . PRO B 1 127 ? 35.297 -2.344 -10.885 1.00 22.17 ? 196 PRO B C 1 ATOM 3978 O O . PRO B 1 127 ? 35.489 -2.579 -9.679 1.00 21.34 ? 196 PRO B O 1 ATOM 3979 C CB . PRO B 1 127 ? 35.897 -0.024 -11.545 1.00 22.60 ? 196 PRO B CB 1 ATOM 3980 C CG . PRO B 1 127 ? 36.043 0.714 -10.261 1.00 22.29 ? 196 PRO B CG 1 ATOM 3981 C CD . PRO B 1 127 ? 34.727 0.674 -9.554 1.00 22.11 ? 196 PRO B CD 1 ATOM 3982 N N . ASP B 1 128 ? 35.533 -3.201 -11.875 1.00 21.76 ? 197 ASP B N 1 ATOM 3983 C CA . ASP B 1 128 ? 35.986 -4.571 -11.638 1.00 22.49 ? 197 ASP B CA 1 ATOM 3984 C C . ASP B 1 128 ? 37.202 -4.629 -10.695 1.00 22.55 ? 197 ASP B C 1 ATOM 3985 O O . ASP B 1 128 ? 37.252 -5.444 -9.804 1.00 21.83 ? 197 ASP B O 1 ATOM 3986 C CB . ASP B 1 128 ? 36.319 -5.236 -12.976 1.00 22.33 ? 197 ASP B CB 1 ATOM 3987 C CG . ASP B 1 128 ? 35.073 -5.519 -13.818 1.00 23.29 ? 197 ASP B CG 1 ATOM 3988 O OD1 . ASP B 1 128 ? 33.905 -5.249 -13.374 1.00 21.09 ? 197 ASP B OD1 1 ATOM 3989 O OD2 . ASP B 1 128 ? 35.263 -6.041 -14.930 1.00 24.92 ? 197 ASP B OD2 1 ATOM 3990 N N . ASN B 1 129 ? 38.134 -3.710 -10.895 1.00 23.19 ? 198 ASN B N 1 ATOM 3991 C CA . ASN B 1 129 ? 39.406 -3.696 -10.202 1.00 24.34 ? 198 ASN B CA 1 ATOM 3992 C C . ASN B 1 129 ? 39.411 -3.000 -8.825 1.00 24.55 ? 198 ASN B C 1 ATOM 3993 O O . ASN B 1 129 ? 40.360 -3.164 -8.059 1.00 25.00 ? 198 ASN B O 1 ATOM 3994 C CB . ASN B 1 129 ? 40.466 -3.083 -11.123 1.00 24.47 ? 198 ASN B CB 1 ATOM 3995 C CG . ASN B 1 129 ? 40.227 -1.620 -11.396 1.00 26.19 ? 198 ASN B CG 1 ATOM 3996 O OD1 . ASN B 1 129 ? 41.151 -0.823 -11.308 1.00 30.59 ? 198 ASN B OD1 1 ATOM 3997 N ND2 . ASN B 1 129 ? 38.983 -1.246 -11.710 1.00 27.33 ? 198 ASN B ND2 1 ATOM 3998 N N . ASN B 1 130 ? 38.359 -2.245 -8.505 1.00 24.97 ? 199 ASN B N 1 ATOM 3999 C CA . ASN B 1 130 ? 38.240 -1.604 -7.185 1.00 24.98 ? 199 ASN B CA 1 ATOM 4000 C C . ASN B 1 130 ? 36.764 -1.474 -6.732 1.00 24.21 ? 199 ASN B C 1 ATOM 4001 O O . ASN B 1 130 ? 36.254 -0.372 -6.473 1.00 24.12 ? 199 ASN B O 1 ATOM 4002 C CB . ASN B 1 130 ? 38.949 -0.247 -7.211 1.00 25.51 ? 199 ASN B CB 1 ATOM 4003 C CG . ASN B 1 130 ? 39.564 0.131 -5.871 1.00 28.18 ? 199 ASN B CG 1 ATOM 4004 O OD1 . ASN B 1 130 ? 39.642 -0.682 -4.944 1.00 33.62 ? 199 ASN B OD1 1 ATOM 4005 N ND2 . ASN B 1 130 ? 40.022 1.378 -5.769 1.00 31.13 ? 199 ASN B ND2 1 ATOM 4006 N N . ALA B 1 131 ? 36.100 -2.620 -6.627 1.00 22.45 ? 200 ALA B N 1 ATOM 4007 C CA . ALA B 1 131 ? 34.700 -2.667 -6.308 1.00 21.81 ? 200 ALA B CA 1 ATOM 4008 C C . ALA B 1 131 ? 34.437 -2.459 -4.806 1.00 21.32 ? 200 ALA B C 1 ATOM 4009 O O . ALA B 1 131 ? 35.325 -2.615 -3.968 1.00 20.50 ? 200 ALA B O 1 ATOM 4010 C CB . ALA B 1 131 ? 34.127 -3.978 -6.757 1.00 22.18 ? 200 ALA B CB 1 ATOM 4011 N N . LEU B 1 132 ? 33.187 -2.130 -4.490 1.00 20.92 ? 201 LEU B N 1 ATOM 4012 C CA . LEU B 1 132 ? 32.801 -1.675 -3.155 1.00 20.51 ? 201 LEU B CA 1 ATOM 4013 C C . LEU B 1 132 ? 31.550 -2.351 -2.620 1.00 19.69 ? 201 LEU B C 1 ATOM 4014 O O . LEU B 1 132 ? 30.467 -2.179 -3.171 1.00 19.31 ? 201 LEU B O 1 ATOM 4015 C CB . LEU B 1 132 ? 32.529 -0.164 -3.203 1.00 20.75 ? 201 LEU B CB 1 ATOM 4016 C CG . LEU B 1 132 ? 32.298 0.437 -1.820 1.00 20.13 ? 201 LEU B CG 1 ATOM 4017 C CD1 . LEU B 1 132 ? 33.593 0.447 -1.030 1.00 21.94 ? 201 LEU B CD1 1 ATOM 4018 C CD2 . LEU B 1 132 ? 31.740 1.794 -1.953 1.00 21.68 ? 201 LEU B CD2 1 ATOM 4019 N N . LEU B 1 133 ? 31.689 -3.067 -1.511 1.00 19.16 ? 202 LEU B N 1 ATOM 4020 C CA . LEU B 1 133 ? 30.529 -3.656 -0.832 1.00 19.11 ? 202 LEU B CA 1 ATOM 4021 C C . LEU B 1 133 ? 29.926 -2.611 0.107 1.00 18.41 ? 202 LEU B C 1 ATOM 4022 O O . LEU B 1 133 ? 30.664 -1.916 0.808 1.00 18.83 ? 202 LEU B O 1 ATOM 4023 C CB . LEU B 1 133 ? 30.913 -4.933 -0.079 1.00 19.46 ? 202 LEU B CB 1 ATOM 4024 C CG . LEU B 1 133 ? 29.824 -5.592 0.768 1.00 19.28 ? 202 LEU B CG 1 ATOM 4025 C CD1 . LEU B 1 133 ? 29.967 -7.081 0.729 1.00 20.30 ? 202 LEU B CD1 1 ATOM 4026 C CD2 . LEU B 1 133 ? 29.866 -5.083 2.208 1.00 19.49 ? 202 LEU B CD2 1 ATOM 4027 N N . LYS B 1 134 ? 28.598 -2.490 0.076 1.00 17.60 ? 203 LYS B N 1 ATOM 4028 C CA . LYS B 1 134 ? 27.866 -1.368 0.697 1.00 17.80 ? 203 LYS B CA 1 ATOM 4029 C C . LYS B 1 134 ? 26.768 -1.943 1.564 1.00 17.33 ? 203 LYS B C 1 ATOM 4030 O O . LYS B 1 134 ? 26.174 -2.933 1.166 1.00 17.42 ? 203 LYS B O 1 ATOM 4031 C CB . LYS B 1 134 ? 27.229 -0.462 -0.360 1.00 17.29 ? 203 LYS B CB 1 ATOM 4032 C CG . LYS B 1 134 ? 28.205 0.254 -1.266 1.00 17.12 ? 203 LYS B CG 1 ATOM 4033 C CD . LYS B 1 134 ? 27.517 1.373 -2.045 1.00 16.97 ? 203 LYS B CD 1 ATOM 4034 C CE . LYS B 1 134 ? 26.675 0.840 -3.211 1.00 18.00 ? 203 LYS B CE 1 ATOM 4035 N NZ . LYS B 1 134 ? 27.469 -0.020 -4.098 1.00 16.91 ? 203 LYS B NZ 1 ATOM 4036 N N . ILE B 1 135 ? 26.524 -1.324 2.728 1.00 17.65 ? 204 ILE B N 1 ATOM 4037 C CA . ILE B 1 135 ? 25.527 -1.799 3.721 1.00 17.85 ? 204 ILE B CA 1 ATOM 4038 C C . ILE B 1 135 ? 24.465 -0.733 4.075 1.00 18.04 ? 204 ILE B C 1 ATOM 4039 O O . ILE B 1 135 ? 24.785 0.399 4.455 1.00 17.72 ? 204 ILE B O 1 ATOM 4040 C CB . ILE B 1 135 ? 26.205 -2.288 5.023 1.00 17.98 ? 204 ILE B CB 1 ATOM 4041 C CG1 . ILE B 1 135 ? 27.256 -3.341 4.711 1.00 17.66 ? 204 ILE B CG1 1 ATOM 4042 C CG2 . ILE B 1 135 ? 25.174 -2.905 6.013 1.00 18.76 ? 204 ILE B CG2 1 ATOM 4043 C CD1 . ILE B 1 135 ? 28.049 -3.743 5.924 1.00 19.53 ? 204 ILE B CD1 1 ATOM 4044 N N . LYS B 1 136 ? 23.201 -1.126 3.924 1.00 18.99 ? 205 LYS B N 1 ATOM 4045 C CA . LYS B 1 136 ? 22.048 -0.342 4.312 1.00 19.67 ? 205 LYS B CA 1 ATOM 4046 C C . LYS B 1 136 ? 21.405 -1.056 5.503 1.00 19.50 ? 205 LYS B C 1 ATOM 4047 O O . LYS B 1 136 ? 21.121 -2.242 5.435 1.00 20.63 ? 205 LYS B O 1 ATOM 4048 C CB . LYS B 1 136 ? 21.079 -0.242 3.123 1.00 20.11 ? 205 LYS B CB 1 ATOM 4049 C CG . LYS B 1 136 ? 20.002 0.894 3.166 1.00 21.95 ? 205 LYS B CG 1 ATOM 4050 C CD . LYS B 1 136 ? 19.480 1.240 1.747 1.00 22.06 ? 205 LYS B CD 1 ATOM 4051 C CE . LYS B 1 136 ? 17.983 1.596 1.694 1.00 23.65 ? 205 LYS B CE 1 ATOM 4052 N NZ . LYS B 1 136 ? 17.026 0.390 1.546 1.00 24.39 ? 205 LYS B NZ 1 ATOM 4053 N N . TYR B 1 137 ? 21.218 -0.352 6.605 1.00 18.86 ? 206 TYR B N 1 ATOM 4054 C CA . TYR B 1 137 ? 20.403 -0.838 7.708 1.00 18.56 ? 206 TYR B CA 1 ATOM 4055 C C . TYR B 1 137 ? 19.137 0.025 7.756 1.00 18.70 ? 206 TYR B C 1 ATOM 4056 O O . TYR B 1 137 ? 19.214 1.256 7.869 1.00 18.32 ? 206 TYR B O 1 ATOM 4057 C CB . TYR B 1 137 ? 21.202 -0.762 9.003 1.00 18.45 ? 206 TYR B CB 1 ATOM 4058 C CG . TYR B 1 137 ? 20.610 -1.564 10.124 1.00 18.91 ? 206 TYR B CG 1 ATOM 4059 C CD1 . TYR B 1 137 ? 20.441 -2.945 10.014 1.00 20.34 ? 206 TYR B CD1 1 ATOM 4060 C CD2 . TYR B 1 137 ? 20.247 -0.953 11.313 1.00 16.84 ? 206 TYR B CD2 1 ATOM 4061 C CE1 . TYR B 1 137 ? 19.909 -3.687 11.074 1.00 19.62 ? 206 TYR B CE1 1 ATOM 4062 C CE2 . TYR B 1 137 ? 19.733 -1.660 12.346 1.00 16.01 ? 206 TYR B CE2 1 ATOM 4063 C CZ . TYR B 1 137 ? 19.557 -3.027 12.240 1.00 18.54 ? 206 TYR B CZ 1 ATOM 4064 O OH . TYR B 1 137 ? 19.023 -3.720 13.314 1.00 17.04 ? 206 TYR B OH 1 ATOM 4065 N N . GLY B 1 138 ? 17.973 -0.613 7.616 1.00 19.20 ? 207 GLY B N 1 ATOM 4066 C CA . GLY B 1 138 ? 16.729 0.084 7.255 1.00 19.99 ? 207 GLY B CA 1 ATOM 4067 C C . GLY B 1 138 ? 16.906 1.006 6.043 1.00 20.69 ? 207 GLY B C 1 ATOM 4068 O O . GLY B 1 138 ? 17.239 0.553 4.941 1.00 21.05 ? 207 GLY B O 1 ATOM 4069 N N . GLU B 1 139 ? 16.703 2.308 6.254 1.00 21.53 ? 208 GLU B N 1 ATOM 4070 C CA . GLU B 1 139 ? 16.944 3.317 5.221 1.00 22.35 ? 208 GLU B CA 1 ATOM 4071 C C . GLU B 1 139 ? 18.374 3.837 5.210 1.00 21.96 ? 208 GLU B C 1 ATOM 4072 O O . GLU B 1 139 ? 18.833 4.326 4.174 1.00 21.80 ? 208 GLU B O 1 ATOM 4073 C CB . GLU B 1 139 ? 16.023 4.517 5.404 1.00 23.32 ? 208 GLU B CB 1 ATOM 4074 C CG . GLU B 1 139 ? 14.537 4.186 5.473 1.00 27.34 ? 208 GLU B CG 1 ATOM 4075 C CD . GLU B 1 139 ? 13.880 4.010 4.114 1.00 33.03 ? 208 GLU B CD 1 ATOM 4076 O OE1 . GLU B 1 139 ? 14.233 4.750 3.152 1.00 36.38 ? 208 GLU B OE1 1 ATOM 4077 O OE2 . GLU B 1 139 ? 12.971 3.147 4.030 1.00 37.69 ? 208 GLU B OE2 1 ATOM 4078 N N . ALA B 1 140 ? 19.081 3.753 6.349 1.00 21.77 ? 209 ALA B N 1 ATOM 4079 C CA . ALA B 1 140 ? 20.416 4.371 6.461 1.00 21.38 ? 209 ALA B CA 1 ATOM 4080 C C . ALA B 1 140 ? 21.493 3.512 5.797 1.00 21.40 ? 209 ALA B C 1 ATOM 4081 O O . ALA B 1 140 ? 21.558 2.311 6.019 1.00 21.43 ? 209 ALA B O 1 ATOM 4082 C CB . ALA B 1 140 ? 20.784 4.656 7.955 1.00 21.76 ? 209 ALA B CB 1 ATOM 4083 N N . TYR B 1 141 ? 22.301 4.128 4.943 1.00 21.08 ? 210 TYR B N 1 ATOM 4084 C CA . TYR B 1 141 ? 23.545 3.541 4.469 1.00 20.58 ? 210 TYR B CA 1 ATOM 4085 C C . TYR B 1 141 ? 24.486 3.709 5.660 1.00 20.69 ? 210 TYR B C 1 ATOM 4086 O O . TYR B 1 141 ? 24.542 4.780 6.254 1.00 19.76 ? 210 TYR B O 1 ATOM 4087 C CB . TYR B 1 141 ? 24.044 4.282 3.212 1.00 20.70 ? 210 TYR B CB 1 ATOM 4088 C CG . TYR B 1 141 ? 23.027 4.196 2.066 1.00 21.53 ? 210 TYR B CG 1 ATOM 4089 C CD1 . TYR B 1 141 ? 22.989 3.095 1.233 1.00 21.79 ? 210 TYR B CD1 1 ATOM 4090 C CD2 . TYR B 1 141 ? 22.060 5.179 1.888 1.00 22.03 ? 210 TYR B CD2 1 ATOM 4091 C CE1 . TYR B 1 141 ? 22.043 2.988 0.215 1.00 23.84 ? 210 TYR B CE1 1 ATOM 4092 C CE2 . TYR B 1 141 ? 21.108 5.082 0.885 1.00 22.99 ? 210 TYR B CE2 1 ATOM 4093 C CZ . TYR B 1 141 ? 21.103 3.978 0.047 1.00 23.82 ? 210 TYR B CZ 1 ATOM 4094 O OH . TYR B 1 141 ? 20.160 3.852 -0.950 1.00 25.56 ? 210 TYR B OH 1 ATOM 4095 N N . THR B 1 142 ? 25.191 2.642 6.029 1.00 20.62 ? 211 THR B N 1 ATOM 4096 C CA . THR B 1 142 ? 25.841 2.556 7.341 1.00 19.72 ? 211 THR B CA 1 ATOM 4097 C C . THR B 1 142 ? 27.311 2.178 7.300 1.00 19.85 ? 211 THR B C 1 ATOM 4098 O O . THR B 1 142 ? 28.045 2.553 8.219 1.00 20.72 ? 211 THR B O 1 ATOM 4099 C CB . THR B 1 142 ? 25.106 1.540 8.254 1.00 19.66 ? 211 THR B CB 1 ATOM 4100 O OG1 . THR B 1 142 ? 24.844 0.329 7.524 1.00 19.16 ? 211 THR B OG1 1 ATOM 4101 C CG2 . THR B 1 142 ? 23.784 2.113 8.754 1.00 18.74 ? 211 THR B CG2 1 ATOM 4102 N N . ASP B 1 143 ? 27.740 1.407 6.295 1.00 19.11 ? 212 ASP B N 1 ATOM 4103 C CA . ASP B 1 143 ? 29.140 0.998 6.169 1.00 18.50 ? 212 ASP B CA 1 ATOM 4104 C C . ASP B 1 143 ? 29.526 0.519 4.742 1.00 18.25 ? 212 ASP B C 1 ATOM 4105 O O . ASP B 1 143 ? 28.663 0.380 3.891 1.00 18.27 ? 212 ASP B O 1 ATOM 4106 C CB . ASP B 1 143 ? 29.394 -0.114 7.156 1.00 18.59 ? 212 ASP B CB 1 ATOM 4107 C CG . ASP B 1 143 ? 30.796 -0.102 7.705 1.00 18.99 ? 212 ASP B CG 1 ATOM 4108 O OD1 . ASP B 1 143 ? 31.670 0.591 7.126 1.00 16.97 ? 212 ASP B OD1 1 ATOM 4109 O OD2 . ASP B 1 143 ? 31.005 -0.810 8.726 1.00 17.77 ? 212 ASP B OD2 1 ATOM 4110 N N . THR B 1 144 ? 30.825 0.329 4.497 1.00 18.35 ? 213 THR B N 1 ATOM 4111 C CA . THR B 1 144 ? 31.332 -0.314 3.281 1.00 19.14 ? 213 THR B CA 1 ATOM 4112 C C . THR B 1 144 ? 32.557 -1.164 3.543 1.00 18.94 ? 213 THR B C 1 ATOM 4113 O O . THR B 1 144 ? 33.174 -1.088 4.607 1.00 19.66 ? 213 THR B O 1 ATOM 4114 C CB . THR B 1 144 ? 31.709 0.664 2.113 1.00 19.23 ? 213 THR B CB 1 ATOM 4115 O OG1 . THR B 1 144 ? 32.816 1.485 2.501 1.00 19.49 ? 213 THR B OG1 1 ATOM 4116 C CG2 . THR B 1 144 ? 30.535 1.510 1.697 1.00 18.57 ? 213 THR B CG2 1 ATOM 4117 N N . TYR B 1 145 ? 32.902 -1.960 2.533 1.00 18.97 ? 214 TYR B N 1 ATOM 4118 C CA . TYR B 1 145 ? 34.073 -2.831 2.566 1.00 18.67 ? 214 TYR B CA 1 ATOM 4119 C C . TYR B 1 145 ? 34.731 -2.827 1.185 1.00 18.96 ? 214 TYR B C 1 ATOM 4120 O O . TYR B 1 145 ? 34.058 -2.904 0.170 1.00 18.85 ? 214 TYR B O 1 ATOM 4121 C CB . TYR B 1 145 ? 33.673 -4.248 3.019 1.00 18.32 ? 214 TYR B CB 1 ATOM 4122 C CG . TYR B 1 145 ? 34.833 -5.084 3.519 1.00 18.12 ? 214 TYR B CG 1 ATOM 4123 C CD1 . TYR B 1 145 ? 35.258 -5.016 4.856 1.00 17.50 ? 214 TYR B CD1 1 ATOM 4124 C CD2 . TYR B 1 145 ? 35.517 -5.927 2.667 1.00 17.66 ? 214 TYR B CD2 1 ATOM 4125 C CE1 . TYR B 1 145 ? 36.342 -5.777 5.317 1.00 15.38 ? 214 TYR B CE1 1 ATOM 4126 C CE2 . TYR B 1 145 ? 36.578 -6.708 3.120 1.00 17.37 ? 214 TYR B CE2 1 ATOM 4127 C CZ . TYR B 1 145 ? 36.990 -6.627 4.448 1.00 16.55 ? 214 TYR B CZ 1 ATOM 4128 O OH . TYR B 1 145 ? 38.063 -7.386 4.862 1.00 13.44 ? 214 TYR B OH 1 ATOM 4129 N N . HIS B 1 146 ? 36.059 -2.703 1.165 1.00 19.80 ? 215 HIS B N 1 ATOM 4130 C CA . HIS B 1 146 ? 36.820 -2.522 -0.069 1.00 19.91 ? 215 HIS B CA 1 ATOM 4131 C C . HIS B 1 146 ? 37.347 -3.834 -0.613 1.00 19.97 ? 215 HIS B C 1 ATOM 4132 O O . HIS B 1 146 ? 37.488 -4.818 0.104 1.00 20.32 ? 215 HIS B O 1 ATOM 4133 C CB . HIS B 1 146 ? 37.979 -1.541 0.129 1.00 19.68 ? 215 HIS B CB 1 ATOM 4134 C CG . HIS B 1 146 ? 37.536 -0.123 0.275 1.00 21.94 ? 215 HIS B CG 1 ATOM 4135 N ND1 . HIS B 1 146 ? 37.167 0.652 -0.807 1.00 24.25 ? 215 HIS B ND1 1 ATOM 4136 C CD2 . HIS B 1 146 ? 37.393 0.662 1.369 1.00 22.49 ? 215 HIS B CD2 1 ATOM 4137 C CE1 . HIS B 1 146 ? 36.816 1.854 -0.382 1.00 23.42 ? 215 HIS B CE1 1 ATOM 4138 N NE2 . HIS B 1 146 ? 36.943 1.883 0.933 1.00 22.92 ? 215 HIS B NE2 1 ATOM 4139 N N . SER B 1 147 ? 37.618 -3.821 -1.911 1.00 19.81 ? 216 SER B N 1 ATOM 4140 C CA . SER B 1 147 ? 38.132 -4.966 -2.614 1.00 19.26 ? 216 SER B CA 1 ATOM 4141 C C . SER B 1 147 ? 39.506 -5.242 -2.005 1.00 19.03 ? 216 SER B C 1 ATOM 4142 O O . SER B 1 147 ? 40.261 -4.325 -1.746 1.00 18.78 ? 216 SER B O 1 ATOM 4143 C CB . SER B 1 147 ? 38.170 -4.631 -4.123 1.00 19.25 ? 216 SER B CB 1 ATOM 4144 O OG . SER B 1 147 ? 38.925 -5.558 -4.869 1.00 19.14 ? 216 SER B OG 1 ATOM 4145 N N . TYR B 1 148 ? 39.789 -6.496 -1.695 1.00 19.29 ? 217 TYR B N 1 ATOM 4146 C CA . TYR B 1 148 ? 41.091 -6.892 -1.157 1.00 19.61 ? 217 TYR B CA 1 ATOM 4147 C C . TYR B 1 148 ? 41.938 -7.619 -2.194 1.00 20.44 ? 217 TYR B C 1 ATOM 4148 O O . TYR B 1 148 ? 43.127 -7.766 -1.977 1.00 22.07 ? 217 TYR B O 1 ATOM 4149 C CB . TYR B 1 148 ? 40.970 -7.763 0.102 1.00 19.83 ? 217 TYR B CB 1 ATOM 4150 C CG . TYR B 1 148 ? 40.055 -8.959 -0.016 1.00 18.90 ? 217 TYR B CG 1 ATOM 4151 C CD1 . TYR B 1 148 ? 40.564 -10.242 -0.142 1.00 19.56 ? 217 TYR B CD1 1 ATOM 4152 C CD2 . TYR B 1 148 ? 38.660 -8.805 0.029 1.00 18.88 ? 217 TYR B CD2 1 ATOM 4153 C CE1 . TYR B 1 148 ? 39.692 -11.367 -0.248 1.00 19.59 ? 217 TYR B CE1 1 ATOM 4154 C CE2 . TYR B 1 148 ? 37.790 -9.906 -0.076 1.00 18.50 ? 217 TYR B CE2 1 ATOM 4155 C CZ . TYR B 1 148 ? 38.303 -11.183 -0.218 1.00 18.87 ? 217 TYR B CZ 1 ATOM 4156 O OH . TYR B 1 148 ? 37.431 -12.263 -0.306 1.00 16.74 ? 217 TYR B OH 1 ATOM 4157 N N . ALA B 1 149 ? 41.357 -8.066 -3.308 1.00 20.53 ? 218 ALA B N 1 ATOM 4158 C CA . ALA B 1 149 ? 42.138 -8.726 -4.358 1.00 20.55 ? 218 ALA B CA 1 ATOM 4159 C C . ALA B 1 149 ? 42.000 -8.025 -5.704 1.00 20.85 ? 218 ALA B C 1 ATOM 4160 O O . ALA B 1 149 ? 42.533 -8.500 -6.698 1.00 21.27 ? 218 ALA B O 1 ATOM 4161 C CB . ALA B 1 149 ? 41.741 -10.177 -4.490 1.00 20.43 ? 218 ALA B CB 1 ATOM 4162 N N . ASN B 1 150 ? 41.288 -6.907 -5.737 1.00 20.73 ? 219 ASN B N 1 ATOM 4163 C CA . ASN B 1 150 ? 41.206 -6.084 -6.929 1.00 20.88 ? 219 ASN B CA 1 ATOM 4164 C C . ASN B 1 150 ? 40.752 -6.855 -8.181 1.00 20.63 ? 219 ASN B C 1 ATOM 4165 O O . ASN B 1 150 ? 41.193 -6.586 -9.296 1.00 20.18 ? 219 ASN B O 1 ATOM 4166 C CB . ASN B 1 150 ? 42.538 -5.365 -7.161 1.00 21.00 ? 219 ASN B CB 1 ATOM 4167 C CG . ASN B 1 150 ? 42.916 -4.447 -5.999 1.00 21.21 ? 219 ASN B CG 1 ATOM 4168 O OD1 . ASN B 1 150 ? 43.835 -4.746 -5.260 1.00 18.25 ? 219 ASN B OD1 1 ATOM 4169 N ND2 . ASN B 1 150 ? 42.197 -3.323 -5.842 1.00 21.93 ? 219 ASN B ND2 1 ATOM 4170 N N . ASN B 1 151 ? 39.854 -7.811 -7.981 1.00 20.67 ? 220 ASN B N 1 ATOM 4171 C CA . ASN B 1 151 ? 39.307 -8.572 -9.097 1.00 20.43 ? 220 ASN B CA 1 ATOM 4172 C C . ASN B 1 151 ? 37.879 -9.039 -8.820 1.00 19.47 ? 220 ASN B C 1 ATOM 4173 O O . ASN B 1 151 ? 37.639 -10.167 -8.436 1.00 18.60 ? 220 ASN B O 1 ATOM 4174 C CB . ASN B 1 151 ? 40.225 -9.737 -9.458 1.00 20.98 ? 220 ASN B CB 1 ATOM 4175 C CG . ASN B 1 151 ? 39.973 -10.271 -10.887 1.00 22.78 ? 220 ASN B CG 1 ATOM 4176 O OD1 . ASN B 1 151 ? 39.002 -9.904 -11.543 1.00 24.19 ? 220 ASN B OD1 1 ATOM 4177 N ND2 . ASN B 1 151 ? 40.853 -11.141 -11.352 1.00 24.22 ? 220 ASN B ND2 1 ATOM 4178 N N . ILE B 1 152 ? 36.946 -8.125 -9.076 1.00 19.03 ? 221 ILE B N 1 ATOM 4179 C CA . ILE B 1 152 ? 35.509 -8.291 -8.865 1.00 18.11 ? 221 ILE B CA 1 ATOM 4180 C C . ILE B 1 152 ? 35.174 -8.834 -7.475 1.00 17.71 ? 221 ILE B C 1 ATOM 4181 O O . ILE B 1 152 ? 34.819 -10.001 -7.323 1.00 17.09 ? 221 ILE B O 1 ATOM 4182 C CB . ILE B 1 152 ? 34.826 -9.148 -9.959 1.00 18.09 ? 221 ILE B CB 1 ATOM 4183 C CG1 . ILE B 1 152 ? 35.400 -8.839 -11.346 1.00 18.19 ? 221 ILE B CG1 1 ATOM 4184 C CG2 . ILE B 1 152 ? 33.303 -8.868 -9.933 1.00 17.66 ? 221 ILE B CG2 1 ATOM 4185 C CD1 . ILE B 1 152 ? 34.972 -9.849 -12.430 1.00 17.18 ? 221 ILE B CD1 1 ATOM 4186 N N . LEU B 1 153 ? 35.285 -7.974 -6.469 1.00 17.61 ? 222 LEU B N 1 ATOM 4187 C CA . LEU B 1 153 ? 34.719 -8.275 -5.165 1.00 17.70 ? 222 LEU B CA 1 ATOM 4188 C C . LEU B 1 153 ? 33.230 -8.558 -5.367 1.00 18.07 ? 222 LEU B C 1 ATOM 4189 O O . LEU B 1 153 ? 32.560 -7.874 -6.138 1.00 17.87 ? 222 LEU B O 1 ATOM 4190 C CB . LEU B 1 153 ? 34.912 -7.103 -4.214 1.00 17.60 ? 222 LEU B CB 1 ATOM 4191 C CG . LEU B 1 153 ? 34.291 -7.113 -2.815 1.00 16.59 ? 222 LEU B CG 1 ATOM 4192 C CD1 . LEU B 1 153 ? 35.102 -7.949 -1.837 1.00 16.33 ? 222 LEU B CD1 1 ATOM 4193 C CD2 . LEU B 1 153 ? 34.196 -5.670 -2.331 1.00 15.12 ? 222 LEU B CD2 1 ATOM 4194 N N . ARG B 1 154 ? 32.738 -9.547 -4.633 1.00 18.61 ? 223 ARG B N 1 ATOM 4195 C CA . ARG B 1 154 ? 31.453 -10.213 -4.882 1.00 19.28 ? 223 ARG B CA 1 ATOM 4196 C C . ARG B 1 154 ? 30.901 -10.716 -3.559 1.00 19.29 ? 223 ARG B C 1 ATOM 4197 O O . ARG B 1 154 ? 31.683 -10.971 -2.637 1.00 18.74 ? 223 ARG B O 1 ATOM 4198 C CB . ARG B 1 154 ? 31.699 -11.476 -5.711 1.00 19.41 ? 223 ARG B CB 1 ATOM 4199 C CG . ARG B 1 154 ? 31.422 -11.383 -7.116 1.00 19.89 ? 223 ARG B CG 1 ATOM 4200 C CD . ARG B 1 154 ? 32.627 -11.816 -7.883 1.00 21.00 ? 223 ARG B CD 1 ATOM 4201 N NE . ARG B 1 154 ? 33.096 -13.190 -7.672 1.00 19.13 ? 223 ARG B NE 1 ATOM 4202 C CZ . ARG B 1 154 ? 34.388 -13.537 -7.635 1.00 18.08 ? 223 ARG B CZ 1 ATOM 4203 N NH1 . ARG B 1 154 ? 35.350 -12.608 -7.704 1.00 17.73 ? 223 ARG B NH1 1 ATOM 4204 N NH2 . ARG B 1 154 ? 34.733 -14.811 -7.492 1.00 17.57 ? 223 ARG B NH2 1 ATOM 4205 N N . THR B 1 155 ? 29.584 -10.951 -3.503 1.00 19.74 ? 224 THR B N 1 ATOM 4206 C CA . THR B 1 155 ? 28.950 -11.585 -2.316 1.00 19.55 ? 224 THR B CA 1 ATOM 4207 C C . THR B 1 155 ? 27.998 -12.728 -2.748 1.00 19.87 ? 224 THR B C 1 ATOM 4208 O O . THR B 1 155 ? 28.102 -13.241 -3.867 1.00 20.57 ? 224 THR B O 1 ATOM 4209 C CB . THR B 1 155 ? 28.269 -10.516 -1.378 1.00 19.56 ? 224 THR B CB 1 ATOM 4210 O OG1 . THR B 1 155 ? 27.801 -11.132 -0.156 1.00 17.79 ? 224 THR B OG1 1 ATOM 4211 C CG2 . THR B 1 155 ? 27.123 -9.786 -2.109 1.00 17.69 ? 224 THR B CG2 1 ATOM 4212 N N . GLN B 1 156 ? 27.086 -13.126 -1.861 1.00 19.92 ? 225 GLN B N 1 ATOM 4213 C CA . GLN B 1 156 ? 26.412 -14.410 -1.968 1.00 19.29 ? 225 GLN B CA 1 ATOM 4214 C C . GLN B 1 156 ? 25.346 -14.552 -3.054 1.00 18.89 ? 225 GLN B C 1 ATOM 4215 O O . GLN B 1 156 ? 25.167 -15.656 -3.565 1.00 19.13 ? 225 GLN B O 1 ATOM 4216 C CB . GLN B 1 156 ? 25.723 -14.752 -0.650 1.00 19.51 ? 225 GLN B CB 1 ATOM 4217 C CG . GLN B 1 156 ? 26.620 -14.898 0.549 1.00 20.47 ? 225 GLN B CG 1 ATOM 4218 C CD . GLN B 1 156 ? 25.830 -15.174 1.817 1.00 21.08 ? 225 GLN B CD 1 ATOM 4219 O OE1 . GLN B 1 156 ? 24.658 -15.509 1.752 1.00 26.99 ? 225 GLN B OE1 1 ATOM 4220 N NE2 . GLN B 1 156 ? 26.461 -15.047 2.966 1.00 21.43 ? 225 GLN B NE2 1 ATOM 4221 N N . GLU B 1 157 ? 24.624 -13.466 -3.364 1.00 18.16 ? 226 GLU B N 1 ATOM 4222 C CA A GLU B 1 157 ? 23.355 -13.508 -4.130 0.60 18.09 ? 226 GLU B CA 1 ATOM 4223 C CA B GLU B 1 157 ? 23.399 -13.550 -4.173 0.40 17.35 ? 226 GLU B CA 1 ATOM 4224 C C . GLU B 1 157 ? 22.328 -14.394 -3.450 1.00 17.41 ? 226 GLU B C 1 ATOM 4225 O O . GLU B 1 157 ? 21.497 -15.062 -4.108 1.00 17.12 ? 226 GLU B O 1 ATOM 4226 C CB A GLU B 1 157 ? 23.552 -13.902 -5.595 0.60 18.53 ? 226 GLU B CB 1 ATOM 4227 C CB B GLU B 1 157 ? 23.689 -14.116 -5.578 0.40 17.16 ? 226 GLU B CB 1 ATOM 4228 C CG A GLU B 1 157 ? 24.189 -12.785 -6.427 0.60 20.56 ? 226 GLU B CG 1 ATOM 4229 C CG B GLU B 1 157 ? 25.005 -13.653 -6.232 0.40 15.88 ? 226 GLU B CG 1 ATOM 4230 C CD A GLU B 1 157 ? 25.659 -12.993 -6.656 0.60 22.53 ? 226 GLU B CD 1 ATOM 4231 C CD B GLU B 1 157 ? 25.088 -12.136 -6.478 0.40 14.53 ? 226 GLU B CD 1 ATOM 4232 O OE1 A GLU B 1 157 ? 26.082 -14.165 -6.650 0.60 24.06 ? 226 GLU B OE1 1 ATOM 4233 O OE1 B GLU B 1 157 ? 24.216 -11.381 -6.001 0.40 12.00 ? 226 GLU B OE1 1 ATOM 4234 O OE2 A GLU B 1 157 ? 26.386 -11.991 -6.858 0.60 23.69 ? 226 GLU B OE2 1 ATOM 4235 O OE2 B GLU B 1 157 ? 26.044 -11.701 -7.160 0.40 14.72 ? 226 GLU B OE2 1 ATOM 4236 N N . SER B 1 158 ? 22.376 -14.375 -2.109 1.00 16.49 ? 227 SER B N 1 ATOM 4237 C CA . SER B 1 158 ? 21.363 -14.983 -1.255 1.00 15.81 ? 227 SER B CA 1 ATOM 4238 C C . SER B 1 158 ? 21.413 -14.449 0.188 1.00 15.88 ? 227 SER B C 1 ATOM 4239 O O . SER B 1 158 ? 22.353 -13.784 0.614 1.00 16.02 ? 227 SER B O 1 ATOM 4240 C CB . SER B 1 158 ? 21.466 -16.512 -1.236 1.00 16.14 ? 227 SER B CB 1 ATOM 4241 O OG . SER B 1 158 ? 22.703 -16.999 -0.733 1.00 15.38 ? 227 SER B OG 1 ATOM 4242 N N . ALA B 1 159 ? 20.363 -14.769 0.928 1.00 16.11 ? 228 ALA B N 1 ATOM 4243 C CA . ALA B 1 159 ? 20.185 -14.365 2.310 1.00 16.02 ? 228 ALA B CA 1 ATOM 4244 C C . ALA B 1 159 ? 21.444 -14.479 3.159 1.00 15.72 ? 228 ALA B C 1 ATOM 4245 O O . ALA B 1 159 ? 22.081 -15.511 3.174 1.00 16.71 ? 228 ALA B O 1 ATOM 4246 C CB . ALA B 1 159 ? 19.064 -15.194 2.917 1.00 16.12 ? 228 ALA B CB 1 ATOM 4247 N N . CYS B 1 160 ? 21.819 -13.403 3.834 1.00 15.67 ? 229 CYS B N 1 ATOM 4248 C CA . CYS B 1 160 ? 22.702 -13.502 4.990 1.00 16.77 ? 229 CYS B CA 1 ATOM 4249 C C . CYS B 1 160 ? 21.909 -14.116 6.162 1.00 16.71 ? 229 CYS B C 1 ATOM 4250 O O . CYS B 1 160 ? 20.741 -14.452 5.994 1.00 16.38 ? 229 CYS B O 1 ATOM 4251 C CB . CYS B 1 160 ? 23.343 -12.147 5.357 1.00 16.44 ? 229 CYS B CB 1 ATOM 4252 S SG . CYS B 1 160 ? 22.400 -10.686 5.059 1.00 19.39 ? 229 CYS B SG 1 ATOM 4253 N N . ASN B 1 161 ? 22.540 -14.257 7.325 1.00 17.14 ? 230 ASN B N 1 ATOM 4254 C CA . ASN B 1 161 ? 21.963 -14.951 8.478 1.00 17.15 ? 230 ASN B CA 1 ATOM 4255 C C . ASN B 1 161 ? 22.315 -14.274 9.780 1.00 17.67 ? 230 ASN B C 1 ATOM 4256 O O . ASN B 1 161 ? 23.484 -14.082 10.077 1.00 18.49 ? 230 ASN B O 1 ATOM 4257 C CB . ASN B 1 161 ? 22.511 -16.370 8.558 1.00 17.48 ? 230 ASN B CB 1 ATOM 4258 C CG . ASN B 1 161 ? 22.043 -17.235 7.417 1.00 18.77 ? 230 ASN B CG 1 ATOM 4259 O OD1 . ASN B 1 161 ? 21.088 -17.982 7.564 1.00 21.04 ? 230 ASN B OD1 1 ATOM 4260 N ND2 . ASN B 1 161 ? 22.705 -17.117 6.253 1.00 20.39 ? 230 ASN B ND2 1 ATOM 4261 N N . CYS B 1 162 ? 21.311 -13.989 10.597 1.00 17.59 ? 231 CYS B N 1 ATOM 4262 C CA . CYS B 1 162 ? 21.502 -13.179 11.793 1.00 18.04 ? 231 CYS B CA 1 ATOM 4263 C C . CYS B 1 162 ? 21.180 -13.970 13.061 1.00 17.02 ? 231 CYS B C 1 ATOM 4264 O O . CYS B 1 162 ? 20.274 -14.784 13.066 1.00 16.10 ? 231 CYS B O 1 ATOM 4265 C CB . CYS B 1 162 ? 20.613 -11.933 11.674 1.00 17.80 ? 231 CYS B CB 1 ATOM 4266 S SG . CYS B 1 162 ? 20.905 -11.021 10.124 1.00 20.93 ? 231 CYS B SG 1 ATOM 4267 N N . ILE B 1 163 ? 21.929 -13.723 14.128 1.00 17.61 ? 232 ILE B N 1 ATOM 4268 C CA . ILE B 1 163 ? 21.702 -14.387 15.427 1.00 18.04 ? 232 ILE B CA 1 ATOM 4269 C C . ILE B 1 163 ? 22.059 -13.428 16.555 1.00 18.11 ? 232 ILE B C 1 ATOM 4270 O O . ILE B 1 163 ? 23.159 -12.884 16.567 1.00 17.97 ? 232 ILE B O 1 ATOM 4271 C CB . ILE B 1 163 ? 22.551 -15.720 15.531 1.00 18.28 ? 232 ILE B CB 1 ATOM 4272 C CG1 . ILE B 1 163 ? 22.208 -16.541 16.781 1.00 18.09 ? 232 ILE B CG1 1 ATOM 4273 C CG2 . ILE B 1 163 ? 24.077 -15.445 15.483 1.00 18.12 ? 232 ILE B CG2 1 ATOM 4274 C CD1 . ILE B 1 163 ? 22.677 -17.989 16.647 1.00 15.72 ? 232 ILE B CD1 1 ATOM 4275 N N . GLY B 1 164 ? 21.159 -13.231 17.514 1.00 19.03 ? 233 GLY B N 1 ATOM 4276 C CA . GLY B 1 164 ? 21.401 -12.265 18.602 1.00 19.43 ? 233 GLY B CA 1 ATOM 4277 C C . GLY B 1 164 ? 21.873 -10.904 18.091 1.00 20.18 ? 233 GLY B C 1 ATOM 4278 O O . GLY B 1 164 ? 22.696 -10.214 18.723 1.00 20.95 ? 233 GLY B O 1 ATOM 4279 N N . GLY B 1 165 ? 21.360 -10.537 16.926 1.00 20.76 ? 234 GLY B N 1 ATOM 4280 C CA . GLY B 1 165 ? 21.728 -9.308 16.231 1.00 21.70 ? 234 GLY B CA 1 ATOM 4281 C C . GLY B 1 165 ? 23.041 -9.262 15.463 1.00 21.78 ? 234 GLY B C 1 ATOM 4282 O O . GLY B 1 165 ? 23.408 -8.209 14.995 1.00 22.37 ? 234 GLY B O 1 ATOM 4283 N N . ASN B 1 166 ? 23.768 -10.371 15.368 1.00 22.47 ? 235 ASN B N 1 ATOM 4284 C CA . ASN B 1 166 ? 25.003 -10.438 14.565 1.00 22.62 ? 235 ASN B CA 1 ATOM 4285 C C . ASN B 1 166 ? 24.720 -11.176 13.275 1.00 23.01 ? 235 ASN B C 1 ATOM 4286 O O . ASN B 1 166 ? 24.396 -12.372 13.307 1.00 23.66 ? 235 ASN B O 1 ATOM 4287 C CB . ASN B 1 166 ? 26.096 -11.174 15.328 1.00 22.51 ? 235 ASN B CB 1 ATOM 4288 C CG . ASN B 1 166 ? 26.347 -10.570 16.689 1.00 22.77 ? 235 ASN B CG 1 ATOM 4289 O OD1 . ASN B 1 166 ? 26.451 -9.364 16.817 1.00 21.91 ? 235 ASN B OD1 1 ATOM 4290 N ND2 . ASN B 1 166 ? 26.439 -11.411 17.717 1.00 24.64 ? 235 ASN B ND2 1 ATOM 4291 N N . CYS B 1 167 ? 24.814 -10.451 12.160 1.00 22.92 ? 236 CYS B N 1 ATOM 4292 C CA . CYS B 1 167 ? 24.515 -10.972 10.826 1.00 22.73 ? 236 CYS B CA 1 ATOM 4293 C C . CYS B 1 167 ? 25.784 -11.356 10.088 1.00 22.14 ? 236 CYS B C 1 ATOM 4294 O O . CYS B 1 167 ? 26.707 -10.563 10.007 1.00 22.83 ? 236 CYS B O 1 ATOM 4295 C CB . CYS B 1 167 ? 23.754 -9.929 10.019 1.00 22.68 ? 236 CYS B CB 1 ATOM 4296 S SG . CYS B 1 167 ? 22.122 -9.521 10.722 1.00 24.47 ? 236 CYS B SG 1 ATOM 4297 N N . TYR B 1 168 ? 25.829 -12.573 9.553 1.00 21.25 ? 237 TYR B N 1 ATOM 4298 C CA . TYR B 1 168 ? 27.049 -13.093 8.928 1.00 20.62 ? 237 TYR B CA 1 ATOM 4299 C C . TYR B 1 168 ? 26.939 -13.179 7.407 1.00 19.72 ? 237 TYR B C 1 ATOM 4300 O O . TYR B 1 168 ? 25.889 -13.508 6.865 1.00 19.65 ? 237 TYR B O 1 ATOM 4301 C CB . TYR B 1 168 ? 27.383 -14.462 9.507 1.00 20.30 ? 237 TYR B CB 1 ATOM 4302 C CG . TYR B 1 168 ? 27.839 -14.421 10.959 1.00 20.68 ? 237 TYR B CG 1 ATOM 4303 C CD1 . TYR B 1 168 ? 29.199 -14.447 11.284 1.00 20.39 ? 237 TYR B CD1 1 ATOM 4304 C CD2 . TYR B 1 168 ? 26.914 -14.386 12.010 1.00 19.64 ? 237 TYR B CD2 1 ATOM 4305 C CE1 . TYR B 1 168 ? 29.630 -14.432 12.631 1.00 18.93 ? 237 TYR B CE1 1 ATOM 4306 C CE2 . TYR B 1 168 ? 27.330 -14.377 13.355 1.00 19.81 ? 237 TYR B CE2 1 ATOM 4307 C CZ . TYR B 1 168 ? 28.689 -14.388 13.661 1.00 20.80 ? 237 TYR B CZ 1 ATOM 4308 O OH . TYR B 1 168 ? 29.104 -14.387 14.993 1.00 21.10 ? 237 TYR B OH 1 ATOM 4309 N N . LEU B 1 169 ? 28.037 -12.901 6.720 1.00 18.81 ? 238 LEU B N 1 ATOM 4310 C CA . LEU B 1 169 ? 27.989 -12.750 5.266 1.00 18.24 ? 238 LEU B CA 1 ATOM 4311 C C . LEU B 1 169 ? 29.286 -13.147 4.586 1.00 17.60 ? 238 LEU B C 1 ATOM 4312 O O . LEU B 1 169 ? 30.336 -12.672 4.933 1.00 17.53 ? 238 LEU B O 1 ATOM 4313 C CB . LEU B 1 169 ? 27.638 -11.302 4.912 1.00 17.90 ? 238 LEU B CB 1 ATOM 4314 C CG . LEU B 1 169 ? 27.725 -10.906 3.432 1.00 16.66 ? 238 LEU B CG 1 ATOM 4315 C CD1 . LEU B 1 169 ? 26.422 -11.246 2.721 1.00 18.69 ? 238 LEU B CD1 1 ATOM 4316 C CD2 . LEU B 1 169 ? 28.056 -9.428 3.293 1.00 15.08 ? 238 LEU B CD2 1 ATOM 4317 N N . MET B 1 170 ? 29.182 -14.024 3.600 1.00 17.74 ? 239 MET B N 1 ATOM 4318 C CA . MET B 1 170 ? 30.307 -14.383 2.727 1.00 17.47 ? 239 MET B CA 1 ATOM 4319 C C . MET B 1 170 ? 30.514 -13.298 1.667 1.00 15.96 ? 239 MET B C 1 ATOM 4320 O O . MET B 1 170 ? 29.562 -12.733 1.146 1.00 14.13 ? 239 MET B O 1 ATOM 4321 C CB . MET B 1 170 ? 30.057 -15.741 2.034 1.00 17.54 ? 239 MET B CB 1 ATOM 4322 C CG . MET B 1 170 ? 31.251 -16.275 1.226 1.00 19.30 ? 239 MET B CG 1 ATOM 4323 S SD . MET B 1 170 ? 31.040 -16.371 -0.580 1.00 23.59 ? 239 MET B SD 1 ATOM 4324 C CE . MET B 1 170 ? 30.343 -14.773 -1.047 1.00 16.36 ? 239 MET B CE 1 ATOM 4325 N N . ILE B 1 171 ? 31.785 -12.989 1.440 1.00 15.80 ? 240 ILE B N 1 ATOM 4326 C CA . ILE B 1 171 ? 32.247 -12.181 0.338 1.00 15.26 ? 240 ILE B CA 1 ATOM 4327 C C . ILE B 1 171 ? 33.478 -12.861 -0.238 1.00 15.92 ? 240 ILE B C 1 ATOM 4328 O O . ILE B 1 171 ? 34.225 -13.557 0.459 1.00 15.11 ? 240 ILE B O 1 ATOM 4329 C CB . ILE B 1 171 ? 32.607 -10.739 0.760 1.00 15.50 ? 240 ILE B CB 1 ATOM 4330 C CG1 . ILE B 1 171 ? 33.786 -10.684 1.750 1.00 14.74 ? 240 ILE B CG1 1 ATOM 4331 C CG2 . ILE B 1 171 ? 31.392 -10.007 1.336 1.00 14.86 ? 240 ILE B CG2 1 ATOM 4332 C CD1 . ILE B 1 171 ? 34.203 -9.238 2.100 1.00 13.42 ? 240 ILE B CD1 1 ATOM 4333 N N . THR B 1 172 ? 33.694 -12.668 -1.527 1.00 16.83 ? 241 THR B N 1 ATOM 4334 C CA . THR B 1 172 ? 34.863 -13.237 -2.157 1.00 17.05 ? 241 THR B CA 1 ATOM 4335 C C . THR B 1 172 ? 35.448 -12.215 -3.112 1.00 17.88 ? 241 THR B C 1 ATOM 4336 O O . THR B 1 172 ? 34.771 -11.259 -3.493 1.00 18.55 ? 241 THR B O 1 ATOM 4337 C CB . THR B 1 172 ? 34.518 -14.562 -2.835 1.00 16.91 ? 241 THR B CB 1 ATOM 4338 O OG1 . THR B 1 172 ? 35.670 -15.408 -2.819 1.00 17.39 ? 241 THR B OG1 1 ATOM 4339 C CG2 . THR B 1 172 ? 34.021 -14.357 -4.280 1.00 17.11 ? 241 THR B CG2 1 ATOM 4340 N N . ASP B 1 173 ? 36.710 -12.409 -3.470 1.00 18.60 ? 242 ASP B N 1 ATOM 4341 C CA . ASP B 1 173 ? 37.404 -11.512 -4.375 1.00 19.12 ? 242 ASP B CA 1 ATOM 4342 C C . ASP B 1 173 ? 38.492 -12.314 -5.087 1.00 19.74 ? 242 ASP B C 1 ATOM 4343 O O . ASP B 1 173 ? 39.191 -13.097 -4.463 1.00 19.76 ? 242 ASP B O 1 ATOM 4344 C CB . ASP B 1 173 ? 37.990 -10.343 -3.575 1.00 19.21 ? 242 ASP B CB 1 ATOM 4345 C CG . ASP B 1 173 ? 38.262 -9.119 -4.422 1.00 18.80 ? 242 ASP B CG 1 ATOM 4346 O OD1 . ASP B 1 173 ? 38.137 -9.181 -5.660 1.00 19.91 ? 242 ASP B OD1 1 ATOM 4347 O OD2 . ASP B 1 173 ? 38.638 -8.083 -3.842 1.00 16.47 ? 242 ASP B OD2 1 ATOM 4348 N N . GLY B 1 174 ? 38.600 -12.141 -6.399 1.00 20.34 ? 243 GLY B N 1 ATOM 4349 C CA . GLY B 1 174 ? 39.614 -12.828 -7.195 1.00 20.77 ? 243 GLY B CA 1 ATOM 4350 C C . GLY B 1 174 ? 39.106 -13.200 -8.565 1.00 21.51 ? 243 GLY B C 1 ATOM 4351 O O . GLY B 1 174 ? 37.966 -12.911 -8.921 1.00 20.36 ? 243 GLY B O 1 ATOM 4352 N N . SER B 1 175 ? 39.967 -13.844 -9.340 1.00 23.41 ? 244 SER B N 1 ATOM 4353 C CA . SER B 1 175 ? 39.639 -14.231 -10.718 1.00 24.20 ? 244 SER B CA 1 ATOM 4354 C C . SER B 1 175 ? 38.535 -15.284 -10.763 1.00 24.88 ? 244 SER B C 1 ATOM 4355 O O . SER B 1 175 ? 38.519 -16.235 -9.964 1.00 24.64 ? 244 SER B O 1 ATOM 4356 C CB . SER B 1 175 ? 40.877 -14.799 -11.426 1.00 24.61 ? 244 SER B CB 1 ATOM 4357 O OG . SER B 1 175 ? 40.575 -15.194 -12.751 1.00 23.13 ? 244 SER B OG 1 ATOM 4358 N N . ALA B 1 176 ? 37.624 -15.114 -11.720 1.00 25.69 ? 245 ALA B N 1 ATOM 4359 C CA . ALA B 1 176 ? 36.553 -16.081 -11.930 1.00 26.32 ? 245 ALA B CA 1 ATOM 4360 C C . ALA B 1 176 ? 37.134 -17.406 -12.430 1.00 26.90 ? 245 ALA B C 1 ATOM 4361 O O . ALA B 1 176 ? 36.487 -18.447 -12.314 1.00 26.46 ? 245 ALA B O 1 ATOM 4362 C CB . ALA B 1 176 ? 35.536 -15.550 -12.899 1.00 26.74 ? 245 ALA B CB 1 ATOM 4363 N N . SER B 1 177 ? 38.377 -17.358 -12.919 1.00 27.34 ? 246 SER B N 1 ATOM 4364 C CA . SER B 1 177 ? 39.057 -18.514 -13.515 1.00 27.82 ? 246 SER B CA 1 ATOM 4365 C C . SER B 1 177 ? 40.291 -18.962 -12.749 1.00 27.45 ? 246 SER B C 1 ATOM 4366 O O . SER B 1 177 ? 41.044 -19.781 -13.245 1.00 27.94 ? 246 SER B O 1 ATOM 4367 C CB . SER B 1 177 ? 39.470 -18.170 -14.946 1.00 27.74 ? 246 SER B CB 1 ATOM 4368 O OG . SER B 1 177 ? 38.322 -18.179 -15.766 1.00 29.96 ? 246 SER B OG 1 ATOM 4369 N N . GLY B 1 178 ? 40.498 -18.423 -11.552 1.00 27.26 ? 247 GLY B N 1 ATOM 4370 C CA . GLY B 1 178 ? 41.659 -18.762 -10.737 1.00 26.49 ? 247 GLY B CA 1 ATOM 4371 C C . GLY B 1 178 ? 41.283 -18.709 -9.274 1.00 26.13 ? 247 GLY B C 1 ATOM 4372 O O . GLY B 1 178 ? 40.213 -19.165 -8.907 1.00 26.07 ? 247 GLY B O 1 ATOM 4373 N N . ILE B 1 179 ? 42.163 -18.127 -8.460 1.00 25.78 ? 248 ILE B N 1 ATOM 4374 C CA . ILE B 1 179 ? 41.991 -18.036 -7.020 1.00 25.53 ? 248 ILE B CA 1 ATOM 4375 C C . ILE B 1 179 ? 40.900 -17.014 -6.692 1.00 25.49 ? 248 ILE B C 1 ATOM 4376 O O . ILE B 1 179 ? 40.845 -15.932 -7.295 1.00 25.98 ? 248 ILE B O 1 ATOM 4377 C CB . ILE B 1 179 ? 43.278 -17.545 -6.295 1.00 25.76 ? 248 ILE B CB 1 ATOM 4378 C CG1 . ILE B 1 179 ? 44.555 -18.276 -6.761 1.00 26.34 ? 248 ILE B CG1 1 ATOM 4379 C CG2 . ILE B 1 179 ? 43.117 -17.674 -4.757 1.00 26.01 ? 248 ILE B CG2 1 ATOM 4380 C CD1 . ILE B 1 179 ? 44.784 -19.633 -6.130 1.00 26.18 ? 248 ILE B CD1 1 ATOM 4381 N N . SER B 1 180 ? 40.034 -17.367 -5.741 1.00 24.80 ? 249 SER B N 1 ATOM 4382 C CA . SER B 1 180 ? 39.094 -16.429 -5.127 1.00 23.87 ? 249 SER B CA 1 ATOM 4383 C C . SER B 1 180 ? 38.880 -16.799 -3.654 1.00 23.12 ? 249 SER B C 1 ATOM 4384 O O . SER B 1 180 ? 37.929 -17.483 -3.301 1.00 23.04 ? 249 SER B O 1 ATOM 4385 C CB . SER B 1 180 ? 37.779 -16.418 -5.886 1.00 23.64 ? 249 SER B CB 1 ATOM 4386 O OG . SER B 1 180 ? 37.945 -15.888 -7.188 1.00 23.48 ? 249 SER B OG 1 ATOM 4387 N N . GLU B 1 181 ? 39.787 -16.330 -2.809 1.00 22.96 ? 250 GLU B N 1 ATOM 4388 C CA A GLU B 1 181 ? 39.796 -16.654 -1.373 0.50 22.25 ? 250 GLU B CA 1 ATOM 4389 C CA B GLU B 1 181 ? 39.779 -16.669 -1.384 0.50 22.59 ? 250 GLU B CA 1 ATOM 4390 C C . GLU B 1 181 ? 38.762 -15.806 -0.662 1.00 22.20 ? 250 GLU B C 1 ATOM 4391 O O . GLU B 1 181 ? 38.945 -14.604 -0.514 1.00 22.48 ? 250 GLU B O 1 ATOM 4392 C CB A GLU B 1 181 ? 41.197 -16.402 -0.782 0.50 22.20 ? 250 GLU B CB 1 ATOM 4393 C CB B GLU B 1 181 ? 41.177 -16.497 -0.780 0.50 22.85 ? 250 GLU B CB 1 ATOM 4394 C CG A GLU B 1 181 ? 41.365 -16.716 0.727 0.50 20.88 ? 250 GLU B CG 1 ATOM 4395 C CG B GLU B 1 181 ? 42.290 -16.906 -1.732 0.50 22.82 ? 250 GLU B CG 1 ATOM 4396 C CD A GLU B 1 181 ? 42.824 -17.001 1.111 0.50 18.88 ? 250 GLU B CD 1 ATOM 4397 C CD B GLU B 1 181 ? 43.477 -17.542 -1.058 0.50 24.31 ? 250 GLU B CD 1 ATOM 4398 O OE1 A GLU B 1 181 ? 43.727 -16.518 0.413 0.50 17.33 ? 250 GLU B OE1 1 ATOM 4399 O OE1 B GLU B 1 181 ? 43.536 -17.561 0.200 0.50 23.20 ? 250 GLU B OE1 1 ATOM 4400 O OE2 A GLU B 1 181 ? 43.084 -17.706 2.107 0.50 19.43 ? 250 GLU B OE2 1 ATOM 4401 O OE2 B GLU B 1 181 ? 44.357 -18.026 -1.817 0.50 26.04 ? 250 GLU B OE2 1 ATOM 4402 N N . CYS B 1 182 ? 37.679 -16.429 -0.224 1.00 22.08 ? 251 CYS B N 1 ATOM 4403 C CA . CYS B 1 182 ? 36.590 -15.701 0.413 1.00 22.43 ? 251 CYS B CA 1 ATOM 4404 C C . CYS B 1 182 ? 36.967 -15.269 1.851 1.00 22.14 ? 251 CYS B C 1 ATOM 4405 O O . CYS B 1 182 ? 38.015 -15.656 2.384 1.00 20.91 ? 251 CYS B O 1 ATOM 4406 C CB . CYS B 1 182 ? 35.294 -16.535 0.415 1.00 22.29 ? 251 CYS B CB 1 ATOM 4407 S SG . CYS B 1 182 ? 35.147 -17.747 1.800 1.00 25.09 ? 251 CYS B SG 1 ATOM 4408 N N . ARG B 1 183 ? 36.140 -14.379 2.394 1.00 21.62 ? 252 ARG B N 1 ATOM 4409 C CA . ARG B 1 183 ? 36.097 -14.082 3.827 1.00 21.38 ? 252 ARG B CA 1 ATOM 4410 C C . ARG B 1 183 ? 34.650 -13.923 4.187 1.00 21.01 ? 252 ARG B C 1 ATOM 4411 O O . ARG B 1 183 ? 33.778 -13.833 3.304 1.00 21.09 ? 252 ARG B O 1 ATOM 4412 C CB . ARG B 1 183 ? 36.794 -12.774 4.195 1.00 21.38 ? 252 ARG B CB 1 ATOM 4413 C CG . ARG B 1 183 ? 37.717 -12.200 3.160 1.00 21.05 ? 252 ARG B CG 1 ATOM 4414 C CD . ARG B 1 183 ? 38.424 -10.966 3.715 1.00 18.83 ? 252 ARG B CD 1 ATOM 4415 N NE . ARG B 1 183 ? 39.844 -11.012 3.418 1.00 15.96 ? 252 ARG B NE 1 ATOM 4416 C CZ . ARG B 1 183 ? 40.642 -9.961 3.366 1.00 14.67 ? 252 ARG B CZ 1 ATOM 4417 N NH1 . ARG B 1 183 ? 40.193 -8.733 3.606 1.00 15.10 ? 252 ARG B NH1 1 ATOM 4418 N NH2 . ARG B 1 183 ? 41.912 -10.149 3.078 1.00 15.34 ? 252 ARG B NH2 1 ATOM 4419 N N . PHE B 1 184 ? 34.424 -13.844 5.484 1.00 21.02 ? 253 PHE B N 1 ATOM 4420 C CA . PHE B 1 184 ? 33.111 -13.646 6.067 1.00 21.31 ? 253 PHE B CA 1 ATOM 4421 C C . PHE B 1 184 ? 33.154 -12.386 6.888 1.00 20.78 ? 253 PHE B C 1 ATOM 4422 O O . PHE B 1 184 ? 34.140 -12.140 7.577 1.00 20.88 ? 253 PHE B O 1 ATOM 4423 C CB . PHE B 1 184 ? 32.747 -14.837 6.963 1.00 21.78 ? 253 PHE B CB 1 ATOM 4424 C CG . PHE B 1 184 ? 32.205 -15.981 6.203 1.00 23.40 ? 253 PHE B CG 1 ATOM 4425 C CD1 . PHE B 1 184 ? 30.838 -16.173 6.104 1.00 25.21 ? 253 PHE B CD1 1 ATOM 4426 C CD2 . PHE B 1 184 ? 33.056 -16.829 5.518 1.00 25.41 ? 253 PHE B CD2 1 ATOM 4427 C CE1 . PHE B 1 184 ? 30.337 -17.211 5.368 1.00 26.72 ? 253 PHE B CE1 1 ATOM 4428 C CE2 . PHE B 1 184 ? 32.558 -17.873 4.761 1.00 26.05 ? 253 PHE B CE2 1 ATOM 4429 C CZ . PHE B 1 184 ? 31.205 -18.060 4.677 1.00 27.45 ? 253 PHE B CZ 1 ATOM 4430 N N . LEU B 1 185 ? 32.105 -11.574 6.800 1.00 19.99 ? 254 LEU B N 1 ATOM 4431 C CA . LEU B 1 185 ? 31.993 -10.415 7.664 1.00 19.16 ? 254 LEU B CA 1 ATOM 4432 C C . LEU B 1 185 ? 30.916 -10.690 8.702 1.00 18.32 ? 254 LEU B C 1 ATOM 4433 O O . LEU B 1 185 ? 29.989 -11.475 8.458 1.00 18.16 ? 254 LEU B O 1 ATOM 4434 C CB . LEU B 1 185 ? 31.675 -9.159 6.864 1.00 18.92 ? 254 LEU B CB 1 ATOM 4435 C CG . LEU B 1 185 ? 32.693 -8.819 5.759 1.00 19.69 ? 254 LEU B CG 1 ATOM 4436 C CD1 . LEU B 1 185 ? 32.143 -7.723 4.854 1.00 17.03 ? 254 LEU B CD1 1 ATOM 4437 C CD2 . LEU B 1 185 ? 34.071 -8.424 6.320 1.00 19.76 ? 254 LEU B CD2 1 ATOM 4438 N N . LYS B 1 186 ? 31.083 -10.063 9.866 1.00 17.19 ? 255 LYS B N 1 ATOM 4439 C CA . LYS B 1 186 ? 30.120 -10.091 10.959 1.00 16.41 ? 255 LYS B CA 1 ATOM 4440 C C . LYS B 1 186 ? 29.581 -8.654 11.123 1.00 16.20 ? 255 LYS B C 1 ATOM 4441 O O . LYS B 1 186 ? 30.318 -7.750 11.511 1.00 16.12 ? 255 LYS B O 1 ATOM 4442 C CB . LYS B 1 186 ? 30.816 -10.535 12.250 1.00 15.99 ? 255 LYS B CB 1 ATOM 4443 C CG . LYS B 1 186 ? 29.936 -10.533 13.494 1.00 15.99 ? 255 LYS B CG 1 ATOM 4444 C CD . LYS B 1 186 ? 30.735 -10.968 14.742 1.00 17.02 ? 255 LYS B CD 1 ATOM 4445 C CE . LYS B 1 186 ? 29.854 -11.109 15.992 1.00 17.85 ? 255 LYS B CE 1 ATOM 4446 N NZ . LYS B 1 186 ? 30.589 -11.667 17.200 1.00 17.94 ? 255 LYS B NZ 1 ATOM 4447 N N . ILE B 1 187 ? 28.289 -8.468 10.861 1.00 15.79 ? 256 ILE B N 1 ATOM 4448 C CA . ILE B 1 187 ? 27.676 -7.143 10.728 1.00 15.36 ? 256 ILE B CA 1 ATOM 4449 C C . ILE B 1 187 ? 26.649 -7.001 11.829 1.00 15.39 ? 256 ILE B C 1 ATOM 4450 O O . ILE B 1 187 ? 25.906 -7.945 12.115 1.00 14.98 ? 256 ILE B O 1 ATOM 4451 C CB . ILE B 1 187 ? 27.006 -6.994 9.296 1.00 15.31 ? 256 ILE B CB 1 ATOM 4452 C CG1 . ILE B 1 187 ? 28.055 -7.195 8.199 1.00 14.56 ? 256 ILE B CG1 1 ATOM 4453 C CG2 . ILE B 1 187 ? 26.325 -5.625 9.110 1.00 15.04 ? 256 ILE B CG2 1 ATOM 4454 C CD1 . ILE B 1 187 ? 27.472 -7.426 6.787 1.00 15.17 ? 256 ILE B CD1 1 ATOM 4455 N N . ARG B 1 188 ? 26.614 -5.858 12.490 1.00 15.73 ? 257 ARG B N 1 ATOM 4456 C CA . ARG B 1 188 ? 25.667 -5.686 13.603 1.00 16.52 ? 257 ARG B CA 1 ATOM 4457 C C . ARG B 1 188 ? 25.098 -4.301 13.448 1.00 16.71 ? 257 ARG B C 1 ATOM 4458 O O . ARG B 1 188 ? 25.835 -3.333 13.315 1.00 17.29 ? 257 ARG B O 1 ATOM 4459 C CB . ARG B 1 188 ? 26.355 -5.909 14.967 1.00 16.60 ? 257 ARG B CB 1 ATOM 4460 C CG . ARG B 1 188 ? 25.485 -5.616 16.204 1.00 18.06 ? 257 ARG B CG 1 ATOM 4461 C CD . ARG B 1 188 ? 26.212 -5.941 17.527 1.00 20.33 ? 257 ARG B CD 1 ATOM 4462 N NE . ARG B 1 188 ? 25.268 -5.926 18.643 1.00 22.42 ? 257 ARG B NE 1 ATOM 4463 C CZ . ARG B 1 188 ? 24.472 -6.938 19.002 1.00 24.16 ? 257 ARG B CZ 1 ATOM 4464 N NH1 . ARG B 1 188 ? 24.482 -8.107 18.355 1.00 25.51 ? 257 ARG B NH1 1 ATOM 4465 N NH2 . ARG B 1 188 ? 23.632 -6.779 20.013 1.00 24.34 ? 257 ARG B NH2 1 ATOM 4466 N N . GLU B 1 189 ? 23.774 -4.221 13.378 1.00 17.77 ? 258 GLU B N 1 ATOM 4467 C CA . GLU B 1 189 ? 23.066 -2.969 13.071 1.00 18.15 ? 258 GLU B CA 1 ATOM 4468 C C . GLU B 1 189 ? 23.665 -2.202 11.886 1.00 17.60 ? 258 GLU B C 1 ATOM 4469 O O . GLU B 1 189 ? 23.639 -0.971 11.846 1.00 17.03 ? 258 GLU B O 1 ATOM 4470 C CB . GLU B 1 189 ? 22.936 -2.110 14.348 1.00 18.13 ? 258 GLU B CB 1 ATOM 4471 C CG . GLU B 1 189 ? 21.806 -2.654 15.233 1.00 20.69 ? 258 GLU B CG 1 ATOM 4472 C CD . GLU B 1 189 ? 21.780 -2.054 16.629 1.00 21.61 ? 258 GLU B CD 1 ATOM 4473 O OE1 . GLU B 1 189 ? 22.841 -1.902 17.237 1.00 22.65 ? 258 GLU B OE1 1 ATOM 4474 O OE2 . GLU B 1 189 ? 20.684 -1.726 17.107 1.00 23.32 ? 258 GLU B OE2 1 ATOM 4475 N N . GLY B 1 190 ? 24.182 -2.954 10.912 1.00 18.01 ? 259 GLY B N 1 ATOM 4476 C CA . GLY B 1 190 ? 24.663 -2.394 9.643 1.00 17.62 ? 259 GLY B CA 1 ATOM 4477 C C . GLY B 1 190 ? 26.129 -2.029 9.598 1.00 18.06 ? 259 GLY B C 1 ATOM 4478 O O . GLY B 1 190 ? 26.619 -1.570 8.561 1.00 18.13 ? 259 GLY B O 1 ATOM 4479 N N . ARG B 1 191 ? 26.851 -2.229 10.701 1.00 18.22 ? 260 ARG B N 1 ATOM 4480 C CA . ARG B 1 191 ? 28.293 -1.971 10.709 1.00 18.51 ? 260 ARG B CA 1 ATOM 4481 C C . ARG B 1 191 ? 29.122 -3.238 10.911 1.00 18.61 ? 260 ARG B C 1 ATOM 4482 O O . ARG B 1 191 ? 28.756 -4.092 11.707 1.00 19.39 ? 260 ARG B O 1 ATOM 4483 C CB . ARG B 1 191 ? 28.632 -0.912 11.749 1.00 18.53 ? 260 ARG B CB 1 ATOM 4484 C CG . ARG B 1 191 ? 27.697 0.286 11.675 1.00 18.72 ? 260 ARG B CG 1 ATOM 4485 C CD . ARG B 1 191 ? 28.247 1.565 12.297 1.00 20.16 ? 260 ARG B CD 1 ATOM 4486 N NE . ARG B 1 191 ? 27.686 2.700 11.583 1.00 21.23 ? 260 ARG B NE 1 ATOM 4487 C CZ . ARG B 1 191 ? 26.423 3.114 11.669 1.00 23.65 ? 260 ARG B CZ 1 ATOM 4488 N NH1 . ARG B 1 191 ? 25.558 2.541 12.498 1.00 23.80 ? 260 ARG B NH1 1 ATOM 4489 N NH2 . ARG B 1 191 ? 26.020 4.131 10.917 1.00 26.39 ? 260 ARG B NH2 1 ATOM 4490 N N . ILE B 1 192 ? 30.236 -3.343 10.185 1.00 18.51 ? 261 ILE B N 1 ATOM 4491 C CA . ILE B 1 192 ? 31.125 -4.516 10.215 1.00 18.44 ? 261 ILE B CA 1 ATOM 4492 C C . ILE B 1 192 ? 31.917 -4.476 11.534 1.00 19.10 ? 261 ILE B C 1 ATOM 4493 O O . ILE B 1 192 ? 32.672 -3.539 11.764 1.00 18.26 ? 261 ILE B O 1 ATOM 4494 C CB . ILE B 1 192 ? 32.064 -4.501 8.972 1.00 18.08 ? 261 ILE B CB 1 ATOM 4495 C CG1 . ILE B 1 192 ? 31.241 -4.555 7.672 1.00 17.46 ? 261 ILE B CG1 1 ATOM 4496 C CG2 . ILE B 1 192 ? 33.047 -5.653 8.955 1.00 17.57 ? 261 ILE B CG2 1 ATOM 4497 C CD1 . ILE B 1 192 ? 32.047 -4.147 6.447 1.00 15.42 ? 261 ILE B CD1 1 ATOM 4498 N N . ILE B 1 193 ? 31.673 -5.441 12.425 1.00 20.44 ? 262 ILE B N 1 ATOM 4499 C CA . ILE B 1 193 ? 32.357 -5.489 13.749 1.00 21.45 ? 262 ILE B CA 1 ATOM 4500 C C . ILE B 1 193 ? 33.417 -6.597 13.797 1.00 21.74 ? 262 ILE B C 1 ATOM 4501 O O . ILE B 1 193 ? 34.163 -6.690 14.757 1.00 22.51 ? 262 ILE B O 1 ATOM 4502 C CB . ILE B 1 193 ? 31.369 -5.635 14.983 1.00 21.70 ? 262 ILE B CB 1 ATOM 4503 C CG1 . ILE B 1 193 ? 30.465 -6.868 14.857 1.00 21.70 ? 262 ILE B CG1 1 ATOM 4504 C CG2 . ILE B 1 193 ? 30.491 -4.394 15.137 1.00 22.62 ? 262 ILE B CG2 1 ATOM 4505 C CD1 . ILE B 1 193 ? 29.794 -7.241 16.124 1.00 21.92 ? 262 ILE B CD1 1 ATOM 4506 N N . LYS B 1 194 ? 33.491 -7.438 12.772 1.00 22.40 ? 263 LYS B N 1 ATOM 4507 C CA . LYS B 1 194 ? 34.586 -8.402 12.679 1.00 22.73 ? 263 LYS B CA 1 ATOM 4508 C C . LYS B 1 194 ? 34.734 -9.001 11.274 1.00 23.41 ? 263 LYS B C 1 ATOM 4509 O O . LYS B 1 194 ? 33.754 -9.148 10.506 1.00 23.04 ? 263 LYS B O 1 ATOM 4510 C CB . LYS B 1 194 ? 34.407 -9.518 13.718 1.00 23.09 ? 263 LYS B CB 1 ATOM 4511 C CG . LYS B 1 194 ? 35.662 -10.353 13.971 1.00 24.80 ? 263 LYS B CG 1 ATOM 4512 C CD . LYS B 1 194 ? 35.374 -11.483 14.954 1.00 26.81 ? 263 LYS B CD 1 ATOM 4513 C CE . LYS B 1 194 ? 35.242 -10.960 16.407 1.00 28.09 ? 263 LYS B CE 1 ATOM 4514 N NZ . LYS B 1 194 ? 35.034 -12.086 17.390 1.00 28.98 ? 263 LYS B NZ 1 ATOM 4515 N N . GLU B 1 195 ? 35.977 -9.334 10.943 1.00 23.80 ? 264 GLU B N 1 ATOM 4516 C CA . GLU B 1 195 ? 36.300 -10.030 9.703 1.00 24.14 ? 264 GLU B CA 1 ATOM 4517 C C . GLU B 1 195 ? 36.793 -11.406 10.093 1.00 23.72 ? 264 GLU B C 1 ATOM 4518 O O . GLU B 1 195 ? 37.661 -11.537 10.949 1.00 23.11 ? 264 GLU B O 1 ATOM 4519 C CB . GLU B 1 195 ? 37.399 -9.313 8.922 1.00 24.25 ? 264 GLU B CB 1 ATOM 4520 C CG . GLU B 1 195 ? 37.160 -7.832 8.685 1.00 26.12 ? 264 GLU B CG 1 ATOM 4521 C CD . GLU B 1 195 ? 38.425 -7.109 8.277 1.00 27.25 ? 264 GLU B CD 1 ATOM 4522 O OE1 . GLU B 1 195 ? 38.783 -7.135 7.080 1.00 27.35 ? 264 GLU B OE1 1 ATOM 4523 O OE2 . GLU B 1 195 ? 39.066 -6.512 9.159 1.00 30.42 ? 264 GLU B OE2 1 ATOM 4524 N N . ILE B 1 196 ? 36.234 -12.427 9.456 1.00 23.43 ? 265 ILE B N 1 ATOM 4525 C CA . ILE B 1 196 ? 36.577 -13.809 9.754 1.00 23.04 ? 265 ILE B CA 1 ATOM 4526 C C . ILE B 1 196 ? 37.298 -14.330 8.507 1.00 22.94 ? 265 ILE B C 1 ATOM 4527 O O . ILE B 1 196 ? 36.797 -14.175 7.359 1.00 23.12 ? 265 ILE B O 1 ATOM 4528 C CB . ILE B 1 196 ? 35.321 -14.637 10.078 1.00 23.02 ? 265 ILE B CB 1 ATOM 4529 C CG1 . ILE B 1 196 ? 34.557 -14.000 11.233 1.00 23.49 ? 265 ILE B CG1 1 ATOM 4530 C CG2 . ILE B 1 196 ? 35.694 -16.070 10.444 1.00 22.21 ? 265 ILE B CG2 1 ATOM 4531 C CD1 . ILE B 1 196 ? 33.159 -14.575 11.419 1.00 25.58 ? 265 ILE B CD1 1 ATOM 4532 N N . PHE B 1 197 ? 38.490 -14.878 8.749 1.00 21.86 ? 266 PHE B N 1 ATOM 4533 C CA . PHE B 1 197 ? 39.401 -15.366 7.731 1.00 21.22 ? 266 PHE B CA 1 ATOM 4534 C C . PHE B 1 197 ? 39.443 -16.908 7.840 1.00 20.78 ? 266 PHE B C 1 ATOM 4535 O O . PHE B 1 197 ? 40.042 -17.464 8.778 1.00 20.76 ? 266 PHE B O 1 ATOM 4536 C CB . PHE B 1 197 ? 40.795 -14.764 7.951 1.00 21.31 ? 266 PHE B CB 1 ATOM 4537 C CG . PHE B 1 197 ? 40.842 -13.247 7.852 1.00 21.68 ? 266 PHE B CG 1 ATOM 4538 C CD1 . PHE B 1 197 ? 40.803 -12.604 6.600 1.00 21.24 ? 266 PHE B CD1 1 ATOM 4539 C CD2 . PHE B 1 197 ? 40.938 -12.463 8.998 1.00 20.63 ? 266 PHE B CD2 1 ATOM 4540 C CE1 . PHE B 1 197 ? 40.845 -11.207 6.506 1.00 21.02 ? 266 PHE B CE1 1 ATOM 4541 C CE2 . PHE B 1 197 ? 40.977 -11.067 8.914 1.00 21.15 ? 266 PHE B CE2 1 ATOM 4542 C CZ . PHE B 1 197 ? 40.929 -10.434 7.654 1.00 21.68 ? 266 PHE B CZ 1 ATOM 4543 N N . PRO B 1 198 ? 38.772 -17.608 6.905 1.00 19.96 ? 267 PRO B N 1 ATOM 4544 C CA . PRO B 1 198 ? 38.699 -19.062 6.938 1.00 19.34 ? 267 PRO B CA 1 ATOM 4545 C C . PRO B 1 198 ? 40.027 -19.771 6.743 1.00 19.29 ? 267 PRO B C 1 ATOM 4546 O O . PRO B 1 198 ? 40.937 -19.210 6.156 1.00 19.16 ? 267 PRO B O 1 ATOM 4547 C CB . PRO B 1 198 ? 37.748 -19.380 5.774 1.00 18.96 ? 267 PRO B CB 1 ATOM 4548 C CG . PRO B 1 198 ? 36.848 -18.230 5.738 1.00 19.26 ? 267 PRO B CG 1 ATOM 4549 C CD . PRO B 1 198 ? 37.760 -17.057 5.982 1.00 19.82 ? 267 PRO B CD 1 ATOM 4550 N N . THR B 1 199 ? 40.115 -21.000 7.250 1.00 19.35 ? 268 THR B N 1 ATOM 4551 C CA . THR B 1 199 ? 41.291 -21.852 7.102 1.00 19.24 ? 268 THR B CA 1 ATOM 4552 C C . THR B 1 199 ? 40.813 -23.060 6.337 1.00 18.66 ? 268 THR B C 1 ATOM 4553 O O . THR B 1 199 ? 39.613 -23.176 6.085 1.00 18.98 ? 268 THR B O 1 ATOM 4554 C CB . THR B 1 199 ? 41.879 -22.283 8.489 1.00 19.49 ? 268 THR B CB 1 ATOM 4555 O OG1 . THR B 1 199 ? 40.946 -23.117 9.190 1.00 20.08 ? 268 THR B OG1 1 ATOM 4556 C CG2 . THR B 1 199 ? 42.193 -21.061 9.344 1.00 18.89 ? 268 THR B CG2 1 ATOM 4557 N N . GLY B 1 200 ? 41.735 -23.946 5.966 1.00 17.94 ? 269 GLY B N 1 ATOM 4558 C CA . GLY B 1 200 ? 41.400 -25.159 5.207 1.00 17.98 ? 269 GLY B CA 1 ATOM 4559 C C . GLY B 1 200 ? 41.472 -24.964 3.693 1.00 18.17 ? 269 GLY B C 1 ATOM 4560 O O . GLY B 1 200 ? 42.341 -24.247 3.191 1.00 16.97 ? 269 GLY B O 1 ATOM 4561 N N . ARG B 1 201 ? 40.538 -25.594 2.975 1.00 18.53 ? 270 ARG B N 1 ATOM 4562 C CA . ARG B 1 201 ? 40.526 -25.590 1.512 1.00 18.52 ? 270 ARG B CA 1 ATOM 4563 C C . ARG B 1 201 ? 40.001 -24.254 1.009 1.00 18.93 ? 270 ARG B C 1 ATOM 4564 O O . ARG B 1 201 ? 38.787 -24.052 0.950 1.00 19.29 ? 270 ARG B O 1 ATOM 4565 C CB . ARG B 1 201 ? 39.637 -26.729 0.994 1.00 19.02 ? 270 ARG B CB 1 ATOM 4566 C CG . ARG B 1 201 ? 39.927 -27.142 -0.476 1.00 17.68 ? 270 ARG B CG 1 ATOM 4567 C CD . ARG B 1 201 ? 39.363 -26.163 -1.446 1.00 18.00 ? 270 ARG B CD 1 ATOM 4568 N NE . ARG B 1 201 ? 39.486 -26.626 -2.826 1.00 18.56 ? 270 ARG B NE 1 ATOM 4569 C CZ . ARG B 1 201 ? 38.869 -26.075 -3.860 1.00 18.49 ? 270 ARG B CZ 1 ATOM 4570 N NH1 . ARG B 1 201 ? 38.053 -25.038 -3.665 1.00 18.73 ? 270 ARG B NH1 1 ATOM 4571 N NH2 . ARG B 1 201 ? 39.064 -26.562 -5.102 1.00 19.07 ? 270 ARG B NH2 1 ATOM 4572 N N . VAL B 1 202 ? 40.895 -23.337 0.648 1.00 18.86 ? 271 VAL B N 1 ATOM 4573 C CA . VAL B 1 202 ? 40.480 -21.944 0.463 1.00 19.05 ? 271 VAL B CA 1 ATOM 4574 C C . VAL B 1 202 ? 40.681 -21.384 -0.967 1.00 19.24 ? 271 VAL B C 1 ATOM 4575 O O . VAL B 1 202 ? 40.354 -20.233 -1.235 1.00 19.39 ? 271 VAL B O 1 ATOM 4576 C CB . VAL B 1 202 ? 41.171 -21.090 1.533 1.00 19.26 ? 271 VAL B CB 1 ATOM 4577 C CG1 . VAL B 1 202 ? 40.709 -19.701 1.470 1.00 20.75 ? 271 VAL B CG1 1 ATOM 4578 C CG2 . VAL B 1 202 ? 40.861 -21.668 2.950 1.00 19.12 ? 271 VAL B CG2 1 ATOM 4579 N N . LYS B 1 203 ? 41.178 -22.222 -1.874 1.00 19.40 ? 272 LYS B N 1 ATOM 4580 C CA . LYS B 1 203 ? 41.528 -21.851 -3.266 1.00 20.08 ? 272 LYS B CA 1 ATOM 4581 C C . LYS B 1 203 ? 40.492 -20.960 -3.986 1.00 19.02 ? 272 LYS B C 1 ATOM 4582 O O . LYS B 1 203 ? 40.825 -19.905 -4.541 1.00 17.98 ? 272 LYS B O 1 ATOM 4583 C CB . LYS B 1 203 ? 41.670 -23.137 -4.092 1.00 20.80 ? 272 LYS B CB 1 ATOM 4584 C CG . LYS B 1 203 ? 42.968 -23.308 -4.808 1.00 23.08 ? 272 LYS B CG 1 ATOM 4585 C CD . LYS B 1 203 ? 42.906 -24.555 -5.685 1.00 26.51 ? 272 LYS B CD 1 ATOM 4586 C CE . LYS B 1 203 ? 43.874 -24.471 -6.882 1.00 28.90 ? 272 LYS B CE 1 ATOM 4587 N NZ . LYS B 1 203 ? 43.875 -25.754 -7.671 1.00 29.84 ? 272 LYS B NZ 1 ATOM 4588 N N . HIS B 1 204 ? 39.242 -21.419 -3.972 1.00 18.81 ? 273 HIS B N 1 ATOM 4589 C CA . HIS B 1 204 ? 38.142 -20.749 -4.680 1.00 18.82 ? 273 HIS B CA 1 ATOM 4590 C C . HIS B 1 204 ? 36.764 -21.028 -4.086 1.00 18.27 ? 273 HIS B C 1 ATOM 4591 O O . HIS B 1 204 ? 36.242 -22.131 -4.167 1.00 18.09 ? 273 HIS B O 1 ATOM 4592 C CB . HIS B 1 204 ? 38.130 -21.153 -6.158 1.00 18.82 ? 273 HIS B CB 1 ATOM 4593 C CG . HIS B 1 204 ? 37.217 -20.314 -6.994 1.00 19.41 ? 273 HIS B CG 1 ATOM 4594 N ND1 . HIS B 1 204 ? 37.664 -19.597 -8.081 1.00 19.23 ? 273 HIS B ND1 1 ATOM 4595 C CD2 . HIS B 1 204 ? 35.892 -20.055 -6.887 1.00 20.47 ? 273 HIS B CD2 1 ATOM 4596 C CE1 . HIS B 1 204 ? 36.650 -18.943 -8.620 1.00 22.24 ? 273 HIS B CE1 1 ATOM 4597 N NE2 . HIS B 1 204 ? 35.563 -19.203 -7.914 1.00 22.19 ? 273 HIS B NE2 1 ATOM 4598 N N . THR B 1 205 ? 36.169 -19.994 -3.531 1.00 18.10 ? 274 THR B N 1 ATOM 4599 C CA . THR B 1 205 ? 34.884 -20.090 -2.903 1.00 18.50 ? 274 THR B CA 1 ATOM 4600 C C . THR B 1 205 ? 34.132 -18.821 -3.241 1.00 18.59 ? 274 THR B C 1 ATOM 4601 O O . THR B 1 205 ? 34.605 -17.703 -2.943 1.00 18.89 ? 274 THR B O 1 ATOM 4602 C CB . THR B 1 205 ? 35.025 -20.229 -1.342 1.00 18.67 ? 274 THR B CB 1 ATOM 4603 O OG1 . THR B 1 205 ? 35.900 -21.316 -1.033 1.00 18.94 ? 274 THR B OG1 1 ATOM 4604 C CG2 . THR B 1 205 ? 33.683 -20.472 -0.691 1.00 19.50 ? 274 THR B CG2 1 ATOM 4605 N N . GLU B 1 206 ? 32.972 -18.998 -3.869 1.00 18.74 ? 275 GLU B N 1 ATOM 4606 C CA . GLU B 1 206 ? 32.075 -17.903 -4.169 1.00 18.55 ? 275 GLU B CA 1 ATOM 4607 C C . GLU B 1 206 ? 30.632 -18.345 -4.112 1.00 18.21 ? 275 GLU B C 1 ATOM 4608 O O . GLU B 1 206 ? 30.337 -19.547 -4.034 1.00 17.79 ? 275 GLU B O 1 ATOM 4609 C CB . GLU B 1 206 ? 32.397 -17.310 -5.530 1.00 18.81 ? 275 GLU B CB 1 ATOM 4610 C CG . GLU B 1 206 ? 32.046 -18.161 -6.747 1.00 20.78 ? 275 GLU B CG 1 ATOM 4611 C CD . GLU B 1 206 ? 32.258 -17.380 -8.050 1.00 22.66 ? 275 GLU B CD 1 ATOM 4612 O OE1 . GLU B 1 206 ? 33.159 -17.741 -8.817 1.00 26.53 ? 275 GLU B OE1 1 ATOM 4613 O OE2 . GLU B 1 206 ? 31.557 -16.375 -8.280 1.00 24.32 ? 275 GLU B OE2 1 ATOM 4614 N N . GLU B 1 207 ? 29.740 -17.353 -4.140 1.00 17.73 ? 276 GLU B N 1 ATOM 4615 C CA . GLU B 1 207 ? 28.296 -17.569 -4.124 1.00 17.46 ? 276 GLU B CA 1 ATOM 4616 C C . GLU B 1 207 ? 27.827 -18.591 -3.090 1.00 17.22 ? 276 GLU B C 1 ATOM 4617 O O . GLU B 1 207 ? 26.999 -19.459 -3.390 1.00 16.63 ? 276 GLU B O 1 ATOM 4618 C CB . GLU B 1 207 ? 27.827 -17.955 -5.506 1.00 17.48 ? 276 GLU B CB 1 ATOM 4619 C CG . GLU B 1 207 ? 27.957 -16.808 -6.474 1.00 18.39 ? 276 GLU B CG 1 ATOM 4620 C CD . GLU B 1 207 ? 27.573 -17.197 -7.881 1.00 17.89 ? 276 GLU B CD 1 ATOM 4621 O OE1 . GLU B 1 207 ? 27.345 -16.310 -8.730 1.00 17.15 ? 276 GLU B OE1 1 ATOM 4622 O OE2 . GLU B 1 207 ? 27.479 -18.410 -8.112 1.00 18.41 ? 276 GLU B OE2 1 ATOM 4623 N N . CYS B 1 208 ? 28.344 -18.461 -1.870 1.00 17.14 ? 277 CYS B N 1 ATOM 4624 C CA . CYS B 1 208 ? 27.978 -19.372 -0.782 1.00 17.46 ? 277 CYS B CA 1 ATOM 4625 C C . CYS B 1 208 ? 26.536 -19.218 -0.424 1.00 16.92 ? 277 CYS B C 1 ATOM 4626 O O . CYS B 1 208 ? 26.043 -18.108 -0.278 1.00 17.38 ? 277 CYS B O 1 ATOM 4627 C CB . CYS B 1 208 ? 28.810 -19.110 0.467 1.00 17.65 ? 277 CYS B CB 1 ATOM 4628 S SG . CYS B 1 208 ? 30.518 -19.604 0.287 1.00 19.73 ? 277 CYS B SG 1 ATOM 4629 N N . THR B 1 209 ? 25.863 -20.351 -0.305 1.00 17.13 ? 278 THR B N 1 ATOM 4630 C CA . THR B 1 209 ? 24.491 -20.427 0.129 1.00 17.02 ? 278 THR B CA 1 ATOM 4631 C C . THR B 1 209 ? 24.559 -20.988 1.554 1.00 17.78 ? 278 THR B C 1 ATOM 4632 O O . THR B 1 209 ? 25.000 -22.115 1.745 1.00 17.65 ? 278 THR B O 1 ATOM 4633 C CB . THR B 1 209 ? 23.701 -21.340 -0.819 1.00 16.50 ? 278 THR B CB 1 ATOM 4634 O OG1 . THR B 1 209 ? 23.901 -20.903 -2.179 1.00 17.46 ? 278 THR B OG1 1 ATOM 4635 C CG2 . THR B 1 209 ? 22.220 -21.298 -0.493 1.00 16.62 ? 278 THR B CG2 1 ATOM 4636 N N . CYS B 1 210 ? 24.160 -20.191 2.540 1.00 18.53 ? 279 CYS B N 1 ATOM 4637 C CA . CYS B 1 210 ? 24.413 -20.482 3.961 1.00 19.45 ? 279 CYS B CA 1 ATOM 4638 C C . CYS B 1 210 ? 23.161 -20.535 4.815 1.00 19.55 ? 279 CYS B C 1 ATOM 4639 O O . CYS B 1 210 ? 22.195 -19.836 4.541 1.00 19.58 ? 279 CYS B O 1 ATOM 4640 C CB . CYS B 1 210 ? 25.252 -19.377 4.584 1.00 19.82 ? 279 CYS B CB 1 ATOM 4641 S SG . CYS B 1 210 ? 26.760 -18.952 3.771 1.00 22.67 ? 279 CYS B SG 1 ATOM 4642 N N . GLY B 1 211 ? 23.212 -21.311 5.893 1.00 19.80 ? 280 GLY B N 1 ATOM 4643 C CA . GLY B 1 211 ? 22.173 -21.266 6.923 1.00 20.14 ? 280 GLY B CA 1 ATOM 4644 C C . GLY B 1 211 ? 22.671 -21.786 8.264 1.00 20.49 ? 280 GLY B C 1 ATOM 4645 O O . GLY B 1 211 ? 23.794 -22.252 8.378 1.00 20.26 ? 280 GLY B O 1 ATOM 4646 N N . PHE B 1 212 ? 21.832 -21.710 9.285 1.00 21.08 ? 281 PHE B N 1 ATOM 4647 C CA . PHE B 1 212 ? 22.204 -22.190 10.616 1.00 21.78 ? 281 PHE B CA 1 ATOM 4648 C C . PHE B 1 212 ? 22.043 -23.712 10.714 1.00 22.37 ? 281 PHE B C 1 ATOM 4649 O O . PHE B 1 212 ? 20.984 -24.251 10.416 1.00 22.70 ? 281 PHE B O 1 ATOM 4650 C CB . PHE B 1 212 ? 21.361 -21.498 11.688 1.00 21.65 ? 281 PHE B CB 1 ATOM 4651 C CG . PHE B 1 212 ? 21.777 -20.079 11.955 1.00 23.00 ? 281 PHE B CG 1 ATOM 4652 C CD1 . PHE B 1 212 ? 22.898 -19.800 12.732 1.00 23.92 ? 281 PHE B CD1 1 ATOM 4653 C CD2 . PHE B 1 212 ? 21.056 -19.014 11.437 1.00 22.81 ? 281 PHE B CD2 1 ATOM 4654 C CE1 . PHE B 1 212 ? 23.290 -18.477 12.973 1.00 22.25 ? 281 PHE B CE1 1 ATOM 4655 C CE2 . PHE B 1 212 ? 21.447 -17.710 11.682 1.00 20.99 ? 281 PHE B CE2 1 ATOM 4656 C CZ . PHE B 1 212 ? 22.551 -17.443 12.450 1.00 21.19 ? 281 PHE B CZ 1 ATOM 4657 N N . ALA B 1 213 ? 23.094 -24.411 11.112 1.00 22.60 ? 282 ALA B N 1 ATOM 4658 C CA . ALA B 1 213 ? 22.949 -25.814 11.500 1.00 22.96 ? 282 ALA B CA 1 ATOM 4659 C C . ALA B 1 213 ? 22.607 -25.897 12.998 1.00 22.52 ? 282 ALA B C 1 ATOM 4660 O O . ALA B 1 213 ? 22.100 -26.917 13.460 1.00 23.20 ? 282 ALA B O 1 ATOM 4661 C CB . ALA B 1 213 ? 24.227 -26.602 11.196 1.00 22.92 ? 282 ALA B CB 1 ATOM 4662 N N . SER B 1 214 ? 22.881 -24.827 13.741 1.00 21.72 ? 283 SER B N 1 ATOM 4663 C CA . SER B 1 214 ? 22.581 -24.765 15.179 1.00 21.45 ? 283 SER B CA 1 ATOM 4664 C C . SER B 1 214 ? 22.743 -23.335 15.693 1.00 21.26 ? 283 SER B C 1 ATOM 4665 O O . SER B 1 214 ? 23.024 -22.424 14.920 1.00 20.26 ? 283 SER B O 1 ATOM 4666 C CB . SER B 1 214 ? 23.537 -25.665 15.959 1.00 20.98 ? 283 SER B CB 1 ATOM 4667 O OG . SER B 1 214 ? 24.829 -25.076 15.990 1.00 20.66 ? 283 SER B OG 1 ATOM 4668 N N . ASN B 1 215 ? 22.592 -23.150 17.008 1.00 21.95 ? 284 ASN B N 1 ATOM 4669 C CA . ASN B 1 215 ? 22.974 -21.877 17.645 1.00 22.28 ? 284 ASN B CA 1 ATOM 4670 C C . ASN B 1 215 ? 24.485 -21.581 17.663 1.00 22.42 ? 284 ASN B C 1 ATOM 4671 O O . ASN B 1 215 ? 24.892 -20.439 17.888 1.00 22.86 ? 284 ASN B O 1 ATOM 4672 C CB . ASN B 1 215 ? 22.430 -21.783 19.067 1.00 22.72 ? 284 ASN B CB 1 ATOM 4673 C CG . ASN B 1 215 ? 20.959 -21.490 19.113 1.00 23.68 ? 284 ASN B CG 1 ATOM 4674 O OD1 . ASN B 1 215 ? 20.476 -20.520 18.530 1.00 22.27 ? 284 ASN B OD1 1 ATOM 4675 N ND2 . ASN B 1 215 ? 20.223 -22.336 19.838 1.00 29.58 ? 284 ASN B ND2 1 ATOM 4676 N N . LYS B 1 216 ? 25.311 -22.595 17.425 1.00 23.11 ? 285 LYS B N 1 ATOM 4677 C CA . LYS B 1 216 ? 26.769 -22.423 17.336 1.00 23.35 ? 285 LYS B CA 1 ATOM 4678 C C . LYS B 1 216 ? 27.298 -22.271 15.917 1.00 22.99 ? 285 LYS B C 1 ATOM 4679 O O . LYS B 1 216 ? 28.299 -21.609 15.708 1.00 23.58 ? 285 LYS B O 1 ATOM 4680 C CB . LYS B 1 216 ? 27.482 -23.649 17.895 1.00 23.84 ? 285 LYS B CB 1 ATOM 4681 C CG . LYS B 1 216 ? 27.496 -23.770 19.394 0.50 24.82 ? 285 LYS B CG 1 ATOM 4682 C CD . LYS B 1 216 ? 28.533 -24.801 19.878 0.50 25.30 ? 285 LYS B CD 1 ATOM 4683 C CE . LYS B 1 216 ? 29.887 -24.732 19.139 0.50 25.79 ? 285 LYS B CE 1 ATOM 4684 N NZ . LYS B 1 216 ? 30.801 -25.842 19.565 0.50 26.31 ? 285 LYS B NZ 1 ATOM 4685 N N . THR B 1 217 ? 26.661 -22.919 14.951 1.00 22.44 ? 286 THR B N 1 ATOM 4686 C CA . THR B 1 217 ? 27.285 -23.130 13.655 1.00 22.09 ? 286 THR B CA 1 ATOM 4687 C C . THR B 1 217 ? 26.431 -22.733 12.458 1.00 21.60 ? 286 THR B C 1 ATOM 4688 O O . THR B 1 217 ? 25.232 -23.001 12.425 1.00 21.76 ? 286 THR B O 1 ATOM 4689 C CB . THR B 1 217 ? 27.652 -24.605 13.511 1.00 22.60 ? 286 THR B CB 1 ATOM 4690 O OG1 . THR B 1 217 ? 28.453 -24.973 14.642 1.00 24.50 ? 286 THR B OG1 1 ATOM 4691 C CG2 . THR B 1 217 ? 28.429 -24.884 12.197 1.00 20.57 ? 286 THR B CG2 1 ATOM 4692 N N . ILE B 1 218 ? 27.085 -22.096 11.489 1.00 20.61 ? 287 ILE B N 1 ATOM 4693 C CA . ILE B 1 218 ? 26.519 -21.757 10.194 1.00 20.12 ? 287 ILE B CA 1 ATOM 4694 C C . ILE B 1 218 ? 27.256 -22.616 9.208 1.00 19.65 ? 287 ILE B C 1 ATOM 4695 O O . ILE B 1 218 ? 28.471 -22.746 9.316 1.00 20.42 ? 287 ILE B O 1 ATOM 4696 C CB . ILE B 1 218 ? 26.761 -20.252 9.795 1.00 19.53 ? 287 ILE B CB 1 ATOM 4697 C CG1 . ILE B 1 218 ? 25.817 -19.326 10.544 1.00 19.21 ? 287 ILE B CG1 1 ATOM 4698 C CG2 . ILE B 1 218 ? 26.540 -20.011 8.285 1.00 21.18 ? 287 ILE B CG2 1 ATOM 4699 C CD1 . ILE B 1 218 ? 26.294 -17.877 10.621 1.00 16.37 ? 287 ILE B CD1 1 ATOM 4700 N N . GLU B 1 219 ? 26.543 -23.208 8.261 1.00 19.07 ? 288 GLU B N 1 ATOM 4701 C CA . GLU B 1 219 ? 27.195 -23.949 7.160 1.00 19.37 ? 288 GLU B CA 1 ATOM 4702 C C . GLU B 1 219 ? 26.810 -23.347 5.826 1.00 18.49 ? 288 GLU B C 1 ATOM 4703 O O . GLU B 1 219 ? 25.758 -22.728 5.712 1.00 17.52 ? 288 GLU B O 1 ATOM 4704 C CB . GLU B 1 219 ? 26.798 -25.446 7.193 1.00 19.61 ? 288 GLU B CB 1 ATOM 4705 C CG . GLU B 1 219 ? 26.924 -26.087 8.579 1.00 20.74 ? 288 GLU B CG 1 ATOM 4706 C CD . GLU B 1 219 ? 26.616 -27.581 8.601 1.00 21.04 ? 288 GLU B CD 1 ATOM 4707 O OE1 . GLU B 1 219 ? 25.593 -28.005 8.035 1.00 21.39 ? 288 GLU B OE1 1 ATOM 4708 O OE2 . GLU B 1 219 ? 27.405 -28.338 9.197 1.00 21.08 ? 288 GLU B OE2 1 ATOM 4709 N N . CYS B 1 220 ? 27.642 -23.556 4.809 1.00 19.36 ? 289 CYS B N 1 ATOM 4710 C CA . CYS B 1 220 ? 27.372 -23.037 3.452 1.00 19.58 ? 289 CYS B CA 1 ATOM 4711 C C . CYS B 1 220 ? 27.830 -23.992 2.350 1.00 19.27 ? 289 CYS B C 1 ATOM 4712 O O . CYS B 1 220 ? 28.848 -24.667 2.501 1.00 19.94 ? 289 CYS B O 1 ATOM 4713 C CB . CYS B 1 220 ? 28.091 -21.687 3.218 1.00 20.09 ? 289 CYS B CB 1 ATOM 4714 S SG . CYS B 1 220 ? 28.064 -20.375 4.529 1.00 23.08 ? 289 CYS B SG 1 ATOM 4715 N N . ALA B 1 221 ? 27.121 -24.008 1.224 1.00 18.67 ? 290 ALA B N 1 ATOM 4716 C CA . ALA B 1 221 ? 27.501 -24.826 0.072 1.00 18.61 ? 290 ALA B CA 1 ATOM 4717 C C . ALA B 1 221 ? 27.822 -23.851 -1.037 1.00 18.70 ? 290 ALA B C 1 ATOM 4718 O O . ALA B 1 221 ? 26.953 -23.103 -1.484 1.00 18.87 ? 290 ALA B O 1 ATOM 4719 C CB . ALA B 1 221 ? 26.373 -25.763 -0.334 1.00 18.45 ? 290 ALA B CB 1 ATOM 4720 N N . CYS B 1 222 ? 29.085 -23.807 -1.440 1.00 19.09 ? 291 CYS B N 1 ATOM 4721 C CA . CYS B 1 222 ? 29.576 -22.690 -2.267 1.00 18.80 ? 291 CYS B CA 1 ATOM 4722 C C . CYS B 1 222 ? 29.877 -23.177 -3.665 1.00 18.97 ? 291 CYS B C 1 ATOM 4723 O O . CYS B 1 222 ? 29.565 -24.323 -3.990 1.00 19.36 ? 291 CYS B O 1 ATOM 4724 C CB . CYS B 1 222 ? 30.778 -22.061 -1.598 1.00 18.79 ? 291 CYS B CB 1 ATOM 4725 S SG . CYS B 1 222 ? 30.466 -21.685 0.157 1.00 19.10 ? 291 CYS B SG 1 ATOM 4726 N N . ARG B 1 223 ? 30.443 -22.316 -4.498 1.00 19.18 ? 292 ARG B N 1 ATOM 4727 C CA . ARG B 1 223 ? 30.750 -22.662 -5.889 1.00 19.52 ? 292 ARG B CA 1 ATOM 4728 C C . ARG B 1 223 ? 32.241 -22.437 -6.155 1.00 20.34 ? 292 ARG B C 1 ATOM 4729 O O . ARG B 1 223 ? 32.744 -21.331 -5.939 1.00 21.39 ? 292 ARG B O 1 ATOM 4730 C CB . ARG B 1 223 ? 29.904 -21.804 -6.824 1.00 19.69 ? 292 ARG B CB 1 ATOM 4731 C CG . ARG B 1 223 ? 30.470 -21.565 -8.225 1.00 18.14 ? 292 ARG B CG 1 ATOM 4732 C CD . ARG B 1 223 ? 29.625 -20.540 -8.935 1.00 16.62 ? 292 ARG B CD 1 ATOM 4733 N NE . ARG B 1 223 ? 30.005 -20.339 -10.331 1.00 15.71 ? 292 ARG B NE 1 ATOM 4734 C CZ . ARG B 1 223 ? 29.324 -19.599 -11.195 1.00 14.51 ? 292 ARG B CZ 1 ATOM 4735 N NH1 . ARG B 1 223 ? 28.186 -19.004 -10.838 1.00 14.99 ? 292 ARG B NH1 1 ATOM 4736 N NH2 . ARG B 1 223 ? 29.761 -19.482 -12.442 1.00 16.38 ? 292 ARG B NH2 1 ATOM 4737 N N . ASP B 1 224 ? 32.958 -23.484 -6.564 1.00 20.42 ? 293 ASP B N 1 ATOM 4738 C CA . ASP B 1 224 ? 34.295 -23.307 -7.094 1.00 21.04 ? 293 ASP B CA 1 ATOM 4739 C C . ASP B 1 224 ? 34.166 -23.164 -8.653 1.00 20.59 ? 293 ASP B C 1 ATOM 4740 O O . ASP B 1 224 ? 33.691 -24.059 -9.317 1.00 20.29 ? 293 ASP B O 1 ATOM 4741 C CB . ASP B 1 224 ? 35.206 -24.474 -6.637 1.00 21.06 ? 293 ASP B CB 1 ATOM 4742 C CG . ASP B 1 224 ? 36.653 -24.354 -7.166 1.00 22.51 ? 293 ASP B CG 1 ATOM 4743 O OD1 . ASP B 1 224 ? 36.823 -23.919 -8.337 1.00 24.48 ? 293 ASP B OD1 1 ATOM 4744 O OD2 . ASP B 1 224 ? 37.612 -24.713 -6.431 1.00 20.89 ? 293 ASP B OD2 1 ATOM 4745 N N . ASN B 1 225 ? 34.544 -22.019 -9.209 1.00 20.55 ? 294 ASN B N 1 ATOM 4746 C CA . ASN B 1 225 ? 34.270 -21.736 -10.627 1.00 20.71 ? 294 ASN B CA 1 ATOM 4747 C C . ASN B 1 225 ? 35.385 -22.192 -11.597 1.00 20.33 ? 294 ASN B C 1 ATOM 4748 O O . ASN B 1 225 ? 35.230 -22.079 -12.812 1.00 19.37 ? 294 ASN B O 1 ATOM 4749 C CB . ASN B 1 225 ? 33.966 -20.243 -10.866 1.00 20.53 ? 294 ASN B CB 1 ATOM 4750 C CG . ASN B 1 225 ? 33.289 -19.997 -12.226 1.00 22.13 ? 294 ASN B CG 1 ATOM 4751 O OD1 . ASN B 1 225 ? 32.300 -20.662 -12.563 1.00 20.08 ? 294 ASN B OD1 1 ATOM 4752 N ND2 . ASN B 1 225 ? 33.817 -19.055 -13.003 1.00 22.99 ? 294 ASN B ND2 1 ATOM 4753 N N . SER B 1 226 ? 36.484 -22.714 -11.051 1.00 20.20 ? 295 SER B N 1 ATOM 4754 C CA . SER B 1 226 ? 37.650 -23.038 -11.843 1.00 20.33 ? 295 SER B CA 1 ATOM 4755 C C . SER B 1 226 ? 38.215 -24.449 -11.681 1.00 20.30 ? 295 SER B C 1 ATOM 4756 O O . SER B 1 226 ? 38.711 -24.985 -12.678 1.00 19.90 ? 295 SER B O 1 ATOM 4757 C CB . SER B 1 226 ? 38.757 -22.007 -11.566 1.00 20.97 ? 295 SER B CB 1 ATOM 4758 O OG . SER B 1 226 ? 38.219 -20.694 -11.529 0.50 20.24 ? 295 SER B OG 1 ATOM 4759 N N . TYR B 1 227 ? 38.147 -25.040 -10.471 1.00 19.55 ? 296 TYR B N 1 ATOM 4760 C CA . TYR B 1 227 ? 38.940 -26.254 -10.131 1.00 19.49 ? 296 TYR B CA 1 ATOM 4761 C C . TYR B 1 227 ? 38.210 -27.584 -9.838 1.00 19.01 ? 296 TYR B C 1 ATOM 4762 O O . TYR B 1 227 ? 38.825 -28.642 -9.906 1.00 18.65 ? 296 TYR B O 1 ATOM 4763 C CB . TYR B 1 227 ? 39.823 -25.987 -8.908 1.00 19.64 ? 296 TYR B CB 1 ATOM 4764 C CG . TYR B 1 227 ? 40.752 -24.843 -9.096 1.00 19.69 ? 296 TYR B CG 1 ATOM 4765 C CD1 . TYR B 1 227 ? 41.855 -24.940 -9.944 1.00 19.18 ? 296 TYR B CD1 1 ATOM 4766 C CD2 . TYR B 1 227 ? 40.532 -23.643 -8.423 1.00 20.65 ? 296 TYR B CD2 1 ATOM 4767 C CE1 . TYR B 1 227 ? 42.706 -23.847 -10.120 1.00 21.34 ? 296 TYR B CE1 1 ATOM 4768 C CE2 . TYR B 1 227 ? 41.355 -22.560 -8.596 1.00 19.56 ? 296 TYR B CE2 1 ATOM 4769 C CZ . TYR B 1 227 ? 42.433 -22.657 -9.429 1.00 20.01 ? 296 TYR B CZ 1 ATOM 4770 O OH . TYR B 1 227 ? 43.236 -21.560 -9.537 1.00 21.39 ? 296 TYR B OH 1 ATOM 4771 N N . THR B 1 228 ? 36.936 -27.543 -9.492 1.00 18.75 ? 297 THR B N 1 ATOM 4772 C CA . THR B 1 228 ? 36.241 -28.756 -9.131 1.00 18.80 ? 297 THR B CA 1 ATOM 4773 C C . THR B 1 228 ? 34.743 -28.614 -9.257 1.00 18.62 ? 297 THR B C 1 ATOM 4774 O O . THR B 1 228 ? 34.197 -27.553 -9.078 1.00 19.00 ? 297 THR B O 1 ATOM 4775 C CB . THR B 1 228 ? 36.572 -29.199 -7.671 1.00 18.82 ? 297 THR B CB 1 ATOM 4776 O OG1 . THR B 1 228 ? 35.880 -30.417 -7.384 1.00 18.79 ? 297 THR B OG1 1 ATOM 4777 C CG2 . THR B 1 228 ? 36.165 -28.137 -6.653 1.00 18.80 ? 297 THR B CG2 1 ATOM 4778 N N . ALA B 1 229 ? 34.094 -29.726 -9.562 1.00 18.66 ? 298 ALA B N 1 ATOM 4779 C CA . ALA B 1 229 ? 32.661 -29.797 -9.611 1.00 17.49 ? 298 ALA B CA 1 ATOM 4780 C C . ALA B 1 229 ? 32.084 -30.136 -8.213 1.00 17.11 ? 298 ALA B C 1 ATOM 4781 O O . ALA B 1 229 ? 30.855 -30.174 -8.051 1.00 16.34 ? 298 ALA B O 1 ATOM 4782 C CB . ALA B 1 229 ? 32.249 -30.825 -10.666 1.00 17.02 ? 298 ALA B CB 1 ATOM 4783 N N . LYS B 1 230 ? 32.957 -30.363 -7.218 1.00 16.18 ? 299 LYS B N 1 ATOM 4784 C CA . LYS B 1 230 ? 32.528 -30.529 -5.805 1.00 16.07 ? 299 LYS B CA 1 ATOM 4785 C C . LYS B 1 230 ? 32.361 -29.175 -5.160 1.00 16.42 ? 299 LYS B C 1 ATOM 4786 O O . LYS B 1 230 ? 33.158 -28.264 -5.401 1.00 17.41 ? 299 LYS B O 1 ATOM 4787 C CB . LYS B 1 230 ? 33.576 -31.288 -4.972 1.00 15.95 ? 299 LYS B CB 1 ATOM 4788 C CG . LYS B 1 230 ? 33.524 -32.803 -5.068 1.00 14.78 ? 299 LYS B CG 1 ATOM 4789 C CD . LYS B 1 230 ? 34.920 -33.382 -4.952 1.00 15.35 ? 299 LYS B CD 1 ATOM 4790 C CE . LYS B 1 230 ? 34.939 -34.782 -4.363 1.00 14.41 ? 299 LYS B CE 1 ATOM 4791 N NZ . LYS B 1 230 ? 36.360 -35.343 -4.309 1.00 13.54 ? 299 LYS B NZ 1 ATOM 4792 N N . ARG B 1 231 ? 31.357 -29.046 -4.304 1.00 16.51 ? 300 ARG B N 1 ATOM 4793 C CA . ARG B 1 231 ? 31.067 -27.766 -3.679 1.00 16.48 ? 300 ARG B CA 1 ATOM 4794 C C . ARG B 1 231 ? 31.931 -27.569 -2.443 1.00 16.42 ? 300 ARG B C 1 ATOM 4795 O O . ARG B 1 231 ? 31.953 -28.437 -1.560 1.00 16.18 ? 300 ARG B O 1 ATOM 4796 C CB . ARG B 1 231 ? 29.598 -27.663 -3.262 1.00 16.64 ? 300 ARG B CB 1 ATOM 4797 C CG . ARG B 1 231 ? 28.635 -27.523 -4.451 1.00 16.83 ? 300 ARG B CG 1 ATOM 4798 C CD . ARG B 1 231 ? 27.396 -26.707 -4.112 1.00 16.39 ? 300 ARG B CD 1 ATOM 4799 N NE . ARG B 1 231 ? 26.566 -26.516 -5.302 1.00 16.81 ? 300 ARG B NE 1 ATOM 4800 C CZ . ARG B 1 231 ? 26.868 -25.708 -6.312 1.00 16.70 ? 300 ARG B CZ 1 ATOM 4801 N NH1 . ARG B 1 231 ? 27.989 -25.000 -6.294 1.00 14.08 ? 300 ARG B NH1 1 ATOM 4802 N NH2 . ARG B 1 231 ? 26.040 -25.614 -7.364 1.00 19.94 ? 300 ARG B NH2 1 ATOM 4803 N N . PRO B 1 232 ? 32.628 -26.424 -2.371 1.00 15.72 ? 301 PRO B N 1 ATOM 4804 C CA . PRO B 1 232 ? 33.286 -26.063 -1.110 1.00 15.77 ? 301 PRO B CA 1 ATOM 4805 C C . PRO B 1 232 ? 32.252 -25.932 -0.009 1.00 15.51 ? 301 PRO B C 1 ATOM 4806 O O . PRO B 1 232 ? 31.135 -25.483 -0.292 1.00 15.97 ? 301 PRO B O 1 ATOM 4807 C CB . PRO B 1 232 ? 33.943 -24.723 -1.429 1.00 15.59 ? 301 PRO B CB 1 ATOM 4808 C CG . PRO B 1 232 ? 34.069 -24.713 -2.968 1.00 15.16 ? 301 PRO B CG 1 ATOM 4809 C CD . PRO B 1 232 ? 32.862 -25.429 -3.435 1.00 15.69 ? 301 PRO B CD 1 ATOM 4810 N N . PHE B 1 233 ? 32.606 -26.313 1.215 1.00 15.55 ? 302 PHE B N 1 ATOM 4811 C CA . PHE B 1 233 ? 31.614 -26.414 2.295 1.00 16.33 ? 302 PHE B CA 1 ATOM 4812 C C . PHE B 1 233 ? 32.125 -25.728 3.532 1.00 16.66 ? 302 PHE B C 1 ATOM 4813 O O . PHE B 1 233 ? 33.069 -26.192 4.165 1.00 17.39 ? 302 PHE B O 1 ATOM 4814 C CB . PHE B 1 233 ? 31.244 -27.889 2.581 1.00 16.04 ? 302 PHE B CB 1 ATOM 4815 C CG . PHE B 1 233 ? 30.093 -28.060 3.556 1.00 16.78 ? 302 PHE B CG 1 ATOM 4816 C CD1 . PHE B 1 233 ? 28.813 -28.349 3.107 1.00 16.34 ? 302 PHE B CD1 1 ATOM 4817 C CD2 . PHE B 1 233 ? 30.298 -27.936 4.949 1.00 18.63 ? 302 PHE B CD2 1 ATOM 4818 C CE1 . PHE B 1 233 ? 27.750 -28.502 4.022 1.00 17.20 ? 302 PHE B CE1 1 ATOM 4819 C CE2 . PHE B 1 233 ? 29.252 -28.098 5.856 1.00 15.09 ? 302 PHE B CE2 1 ATOM 4820 C CZ . PHE B 1 233 ? 27.974 -28.368 5.395 1.00 15.23 ? 302 PHE B CZ 1 ATOM 4821 N N . VAL B 1 234 ? 31.503 -24.619 3.882 1.00 17.30 ? 303 VAL B N 1 ATOM 4822 C CA . VAL B 1 234 ? 31.983 -23.795 4.972 1.00 18.12 ? 303 VAL B CA 1 ATOM 4823 C C . VAL B 1 234 ? 31.337 -24.192 6.307 1.00 18.82 ? 303 VAL B C 1 ATOM 4824 O O . VAL B 1 234 ? 30.135 -24.326 6.367 1.00 18.99 ? 303 VAL B O 1 ATOM 4825 C CB . VAL B 1 234 ? 31.646 -22.312 4.697 1.00 18.45 ? 303 VAL B CB 1 ATOM 4826 C CG1 . VAL B 1 234 ? 32.188 -21.425 5.818 1.00 18.22 ? 303 VAL B CG1 1 ATOM 4827 C CG2 . VAL B 1 234 ? 32.169 -21.878 3.311 1.00 15.47 ? 303 VAL B CG2 1 ATOM 4828 N N . LYS B 1 235 ? 32.125 -24.355 7.369 1.00 19.56 ? 304 LYS B N 1 ATOM 4829 C CA . LYS B 1 235 ? 31.570 -24.522 8.729 1.00 20.03 ? 304 LYS B CA 1 ATOM 4830 C C . LYS B 1 235 ? 32.076 -23.373 9.555 1.00 20.58 ? 304 LYS B C 1 ATOM 4831 O O . LYS B 1 235 ? 33.273 -23.258 9.762 1.00 20.81 ? 304 LYS B O 1 ATOM 4832 C CB . LYS B 1 235 ? 32.009 -25.833 9.370 1.00 20.23 ? 304 LYS B CB 1 ATOM 4833 C CG . LYS B 1 235 ? 31.356 -27.095 8.791 1.00 20.89 ? 304 LYS B CG 1 ATOM 4834 C CD . LYS B 1 235 ? 31.687 -28.311 9.643 1.00 21.52 ? 304 LYS B CD 1 ATOM 4835 C CE . LYS B 1 235 ? 31.721 -29.611 8.868 1.00 21.91 ? 304 LYS B CE 1 ATOM 4836 N NZ . LYS B 1 235 ? 32.007 -30.790 9.782 1.00 22.25 ? 304 LYS B NZ 1 ATOM 4837 N N . LEU B 1 236 ? 31.176 -22.502 9.997 1.00 21.48 ? 305 LEU B N 1 ATOM 4838 C CA . LEU B 1 236 ? 31.562 -21.268 10.673 1.00 21.93 ? 305 LEU B CA 1 ATOM 4839 C C . LEU B 1 236 ? 30.983 -21.256 12.091 1.00 22.51 ? 305 LEU B C 1 ATOM 4840 O O . LEU B 1 236 ? 29.766 -21.292 12.281 1.00 23.36 ? 305 LEU B O 1 ATOM 4841 C CB . LEU B 1 236 ? 31.051 -20.076 9.861 1.00 21.87 ? 305 LEU B CB 1 ATOM 4842 C CG . LEU B 1 236 ? 31.480 -18.644 10.193 1.00 21.85 ? 305 LEU B CG 1 ATOM 4843 C CD1 . LEU B 1 236 ? 30.832 -17.720 9.165 1.00 20.10 ? 305 LEU B CD1 1 ATOM 4844 C CD2 . LEU B 1 236 ? 31.120 -18.256 11.625 1.00 19.79 ? 305 LEU B CD2 1 ATOM 4845 N N . ASN B 1 237 ? 31.854 -21.222 13.084 1.00 22.94 ? 306 ASN B N 1 ATOM 4846 C CA . ASN B 1 237 ? 31.436 -21.171 14.487 1.00 23.00 ? 306 ASN B CA 1 ATOM 4847 C C . ASN B 1 237 ? 31.125 -19.736 14.900 1.00 23.51 ? 306 ASN B C 1 ATOM 4848 O O . ASN B 1 237 ? 31.996 -18.872 14.874 1.00 23.50 ? 306 ASN B O 1 ATOM 4849 C CB . ASN B 1 237 ? 32.539 -21.761 15.368 1.00 22.81 ? 306 ASN B CB 1 ATOM 4850 C CG . ASN B 1 237 ? 32.179 -21.766 16.865 1.00 23.09 ? 306 ASN B CG 1 ATOM 4851 O OD1 . ASN B 1 237 ? 31.668 -20.789 17.401 1.00 22.50 ? 306 ASN B OD1 1 ATOM 4852 N ND2 . ASN B 1 237 ? 32.472 -22.867 17.533 1.00 21.78 ? 306 ASN B ND2 1 ATOM 4853 N N . VAL B 1 238 ? 29.891 -19.481 15.312 1.00 24.38 ? 307 VAL B N 1 ATOM 4854 C CA . VAL B 1 238 ? 29.476 -18.118 15.631 1.00 25.59 ? 307 VAL B CA 1 ATOM 4855 C C . VAL B 1 238 ? 29.729 -17.701 17.095 1.00 26.21 ? 307 VAL B C 1 ATOM 4856 O O . VAL B 1 238 ? 29.387 -16.580 17.485 1.00 26.20 ? 307 VAL B O 1 ATOM 4857 C CB . VAL B 1 238 ? 27.970 -17.857 15.257 1.00 25.59 ? 307 VAL B CB 1 ATOM 4858 C CG1 . VAL B 1 238 ? 27.734 -18.085 13.763 1.00 25.49 ? 307 VAL B CG1 1 ATOM 4859 C CG2 . VAL B 1 238 ? 27.038 -18.707 16.099 1.00 26.09 ? 307 VAL B CG2 1 ATOM 4860 N N . GLU B 1 239 ? 30.306 -18.607 17.893 1.00 27.24 ? 308 GLU B N 1 ATOM 4861 C CA . GLU B 1 239 ? 30.647 -18.351 19.309 1.00 27.33 ? 308 GLU B CA 1 ATOM 4862 C C . GLU B 1 239 ? 32.101 -17.882 19.436 1.00 26.66 ? 308 GLU B C 1 ATOM 4863 O O . GLU B 1 239 ? 32.407 -16.993 20.219 1.00 26.57 ? 308 GLU B O 1 ATOM 4864 C CB . GLU B 1 239 ? 30.476 -19.624 20.149 1.00 28.41 ? 308 GLU B CB 1 ATOM 4865 C CG . GLU B 1 239 ? 29.071 -19.883 20.698 1.00 30.64 ? 308 GLU B CG 1 ATOM 4866 C CD . GLU B 1 239 ? 28.947 -21.268 21.349 1.00 34.38 ? 308 GLU B CD 1 ATOM 4867 O OE1 . GLU B 1 239 ? 29.988 -21.926 21.631 1.00 35.54 ? 308 GLU B OE1 1 ATOM 4868 O OE2 . GLU B 1 239 ? 27.796 -21.710 21.576 1.00 36.84 ? 308 GLU B OE2 1 ATOM 4869 N N . THR B 1 240 ? 32.991 -18.511 18.666 1.00 25.64 ? 309 THR B N 1 ATOM 4870 C CA . THR B 1 240 ? 34.405 -18.146 18.614 1.00 24.24 ? 309 THR B CA 1 ATOM 4871 C C . THR B 1 240 ? 34.772 -17.321 17.368 1.00 24.09 ? 309 THR B C 1 ATOM 4872 O O . THR B 1 240 ? 35.915 -16.872 17.241 1.00 23.53 ? 309 THR B O 1 ATOM 4873 C CB . THR B 1 240 ? 35.265 -19.419 18.606 1.00 24.32 ? 309 THR B CB 1 ATOM 4874 O OG1 . THR B 1 240 ? 35.005 -20.155 17.410 1.00 23.21 ? 309 THR B OG1 1 ATOM 4875 C CG2 . THR B 1 240 ? 34.955 -20.315 19.836 1.00 22.56 ? 309 THR B CG2 1 ATOM 4876 N N . ASP B 1 241 ? 33.813 -17.143 16.448 1.00 23.49 ? 310 ASP B N 1 ATOM 4877 C CA . ASP B 1 241 ? 34.012 -16.394 15.188 1.00 23.40 ? 310 ASP B CA 1 ATOM 4878 C C . ASP B 1 241 ? 35.184 -16.881 14.337 1.00 22.89 ? 310 ASP B C 1 ATOM 4879 O O . ASP B 1 241 ? 36.072 -16.111 13.994 1.00 22.65 ? 310 ASP B O 1 ATOM 4880 C CB . ASP B 1 241 ? 34.124 -14.883 15.449 1.00 23.00 ? 310 ASP B CB 1 ATOM 4881 C CG . ASP B 1 241 ? 32.794 -14.262 15.757 1.00 23.67 ? 310 ASP B CG 1 ATOM 4882 O OD1 . ASP B 1 241 ? 31.768 -14.802 15.265 1.00 19.43 ? 310 ASP B OD1 1 ATOM 4883 O OD2 . ASP B 1 241 ? 32.765 -13.246 16.513 1.00 27.17 ? 310 ASP B OD2 1 ATOM 4884 N N . THR B 1 242 ? 35.134 -18.160 13.975 1.00 22.90 ? 311 THR B N 1 ATOM 4885 C CA . THR B 1 242 ? 36.208 -18.859 13.278 1.00 22.66 ? 311 THR B CA 1 ATOM 4886 C C . THR B 1 242 ? 35.566 -19.723 12.225 1.00 22.35 ? 311 THR B C 1 ATOM 4887 O O . THR B 1 242 ? 34.474 -20.233 12.459 1.00 22.80 ? 311 THR B O 1 ATOM 4888 C CB . THR B 1 242 ? 36.941 -19.813 14.240 1.00 22.76 ? 311 THR B CB 1 ATOM 4889 O OG1 . THR B 1 242 ? 35.961 -20.433 15.088 1.00 24.57 ? 311 THR B OG1 1 ATOM 4890 C CG2 . THR B 1 242 ? 37.950 -19.059 15.088 1.00 21.77 ? 311 THR B CG2 1 ATOM 4891 N N . ALA B 1 243 ? 36.249 -19.930 11.102 1.00 21.34 ? 312 ALA B N 1 ATOM 4892 C CA . ALA B 1 243 ? 35.653 -20.607 9.954 1.00 21.13 ? 312 ALA B CA 1 ATOM 4893 C C . ALA B 1 243 ? 36.646 -21.547 9.246 1.00 20.50 ? 312 ALA B C 1 ATOM 4894 O O . ALA B 1 243 ? 37.805 -21.193 9.055 1.00 20.19 ? 312 ALA B O 1 ATOM 4895 C CB . ALA B 1 243 ? 35.124 -19.579 8.977 1.00 20.96 ? 312 ALA B CB 1 ATOM 4896 N N . GLU B 1 244 ? 36.187 -22.741 8.873 1.00 19.92 ? 313 GLU B N 1 ATOM 4897 C CA . GLU B 1 244 ? 37.008 -23.682 8.125 1.00 19.73 ? 313 GLU B CA 1 ATOM 4898 C C . GLU B 1 244 ? 36.264 -24.138 6.866 1.00 18.88 ? 313 GLU B C 1 ATOM 4899 O O . GLU B 1 244 ? 35.063 -24.356 6.921 1.00 17.41 ? 313 GLU B O 1 ATOM 4900 C CB . GLU B 1 244 ? 37.380 -24.891 8.990 1.00 19.92 ? 313 GLU B CB 1 ATOM 4901 C CG . GLU B 1 244 ? 38.449 -25.798 8.330 1.00 22.94 ? 313 GLU B CG 1 ATOM 4902 C CD . GLU B 1 244 ? 38.745 -27.090 9.098 1.00 25.17 ? 313 GLU B CD 1 ATOM 4903 O OE1 . GLU B 1 244 ? 38.269 -27.239 10.235 1.00 27.35 ? 313 GLU B OE1 1 ATOM 4904 O OE2 . GLU B 1 244 ? 39.446 -27.973 8.547 1.00 27.32 ? 313 GLU B OE2 1 ATOM 4905 N N . ILE B 1 245 ? 36.980 -24.255 5.738 1.00 18.64 ? 314 ILE B N 1 ATOM 4906 C CA . ILE B 1 245 ? 36.402 -24.773 4.481 1.00 18.14 ? 314 ILE B CA 1 ATOM 4907 C C . ILE B 1 245 ? 37.056 -26.096 4.046 1.00 18.57 ? 314 ILE B C 1 ATOM 4908 O O . ILE B 1 245 ? 38.274 -26.200 4.007 1.00 19.18 ? 314 ILE B O 1 ATOM 4909 C CB . ILE B 1 245 ? 36.570 -23.783 3.322 1.00 17.62 ? 314 ILE B CB 1 ATOM 4910 C CG1 . ILE B 1 245 ? 36.092 -22.394 3.732 1.00 17.05 ? 314 ILE B CG1 1 ATOM 4911 C CG2 . ILE B 1 245 ? 35.800 -24.268 2.087 1.00 17.24 ? 314 ILE B CG2 1 ATOM 4912 C CD1 . ILE B 1 245 ? 36.049 -21.366 2.609 1.00 14.12 ? 314 ILE B CD1 1 ATOM 4913 N N . ARG B 1 246 ? 36.240 -27.101 3.738 1.00 19.63 ? 315 ARG B N 1 ATOM 4914 C CA . ARG B 1 246 ? 36.670 -28.304 2.977 1.00 20.24 ? 315 ARG B CA 1 ATOM 4915 C C . ARG B 1 246 ? 35.626 -28.596 1.921 1.00 20.11 ? 315 ARG B C 1 ATOM 4916 O O . ARG B 1 246 ? 34.463 -28.216 2.099 1.00 19.74 ? 315 ARG B O 1 ATOM 4917 C CB . ARG B 1 246 ? 36.788 -29.554 3.873 1.00 21.17 ? 315 ARG B CB 1 ATOM 4918 C CG . ARG B 1 246 ? 37.613 -29.412 5.148 1.00 22.87 ? 315 ARG B CG 1 ATOM 4919 C CD . ARG B 1 246 ? 39.093 -29.413 4.820 1.00 26.73 ? 315 ARG B CD 1 ATOM 4920 N NE . ARG B 1 246 ? 39.912 -28.952 5.939 1.00 29.49 ? 315 ARG B NE 1 ATOM 4921 C CZ . ARG B 1 246 ? 41.185 -28.569 5.857 1.00 29.74 ? 315 ARG B CZ 1 ATOM 4922 N NH1 . ARG B 1 246 ? 41.831 -28.562 4.693 1.00 30.69 ? 315 ARG B NH1 1 ATOM 4923 N NH2 . ARG B 1 246 ? 41.810 -28.162 6.957 1.00 29.85 ? 315 ARG B NH2 1 ATOM 4924 N N . LEU B 1 247 ? 36.019 -29.278 0.844 1.00 20.29 ? 316 LEU B N 1 ATOM 4925 C CA . LEU B 1 247 ? 35.065 -29.685 -0.198 1.00 21.41 ? 316 LEU B CA 1 ATOM 4926 C C . LEU B 1 247 ? 34.083 -30.756 0.314 1.00 21.73 ? 316 LEU B C 1 ATOM 4927 O O . LEU B 1 247 ? 34.444 -31.565 1.164 1.00 21.97 ? 316 LEU B O 1 ATOM 4928 C CB . LEU B 1 247 ? 35.788 -30.268 -1.432 1.00 21.12 ? 316 LEU B CB 1 ATOM 4929 C CG . LEU B 1 247 ? 36.688 -29.398 -2.303 1.00 21.60 ? 316 LEU B CG 1 ATOM 4930 C CD1 . LEU B 1 247 ? 37.284 -30.289 -3.400 1.00 20.50 ? 316 LEU B CD1 1 ATOM 4931 C CD2 . LEU B 1 247 ? 35.933 -28.222 -2.905 1.00 19.65 ? 316 LEU B CD2 1 ATOM 4932 N N . MET B 1 248 ? 32.858 -30.766 -0.223 1.00 22.28 ? 317 MET B N 1 ATOM 4933 C CA . MET B 1 248 ? 31.888 -31.847 0.044 1.00 22.24 ? 317 MET B CA 1 ATOM 4934 C C . MET B 1 248 ? 32.392 -33.179 -0.499 1.00 22.60 ? 317 MET B C 1 ATOM 4935 O O . MET B 1 248 ? 32.875 -33.254 -1.638 1.00 22.39 ? 317 MET B O 1 ATOM 4936 C CB . MET B 1 248 ? 30.525 -31.558 -0.607 1.00 22.72 ? 317 MET B CB 1 ATOM 4937 C CG . MET B 1 248 ? 29.761 -30.323 -0.091 1.00 22.00 ? 317 MET B CG 1 ATOM 4938 S SD . MET B 1 248 ? 28.081 -30.267 -0.762 1.00 19.10 ? 317 MET B SD 1 ATOM 4939 C CE . MET B 1 248 ? 27.388 -31.750 -0.036 1.00 20.98 ? 317 MET B CE 1 ATOM 4940 N N . CYS B 1 249 ? 32.263 -34.238 0.294 1.00 22.86 ? 318 CYS B N 1 ATOM 4941 C CA . CYS B 1 249 ? 32.847 -35.537 -0.103 1.00 23.14 ? 318 CYS B CA 1 ATOM 4942 C C . CYS B 1 249 ? 31.921 -36.387 -0.995 1.00 21.88 ? 318 CYS B C 1 ATOM 4943 O O . CYS B 1 249 ? 32.404 -37.227 -1.740 1.00 21.75 ? 318 CYS B O 1 ATOM 4944 C CB . CYS B 1 249 ? 33.293 -36.352 1.124 1.00 23.26 ? 318 CYS B CB 1 ATOM 4945 S SG . CYS B 1 249 ? 34.429 -37.692 0.668 1.00 26.32 ? 318 CYS B SG 1 ATOM 4946 N N . THR B 1 250 ? 30.612 -36.155 -0.903 1.00 20.49 ? 319 THR B N 1 ATOM 4947 C CA . THR B 1 250 ? 29.600 -36.919 -1.644 1.00 19.67 ? 319 THR B CA 1 ATOM 4948 C C . THR B 1 250 ? 29.936 -37.158 -3.137 1.00 20.08 ? 319 THR B C 1 ATOM 4949 O O . THR B 1 250 ? 30.504 -36.294 -3.819 1.00 19.00 ? 319 THR B O 1 ATOM 4950 C CB . THR B 1 250 ? 28.179 -36.261 -1.468 1.00 19.69 ? 319 THR B CB 1 ATOM 4951 O OG1 . THR B 1 250 ? 27.163 -37.107 -1.990 1.00 16.52 ? 319 THR B OG1 1 ATOM 4952 C CG2 . THR B 1 250 ? 28.083 -34.848 -2.091 1.00 18.51 ? 319 THR B CG2 1 ATOM 4953 N N . GLU B 1 251 ? 29.614 -38.362 -3.618 1.00 20.29 ? 320 GLU B N 1 ATOM 4954 C CA . GLU B 1 251 ? 29.738 -38.683 -5.040 1.00 20.79 ? 320 GLU B CA 1 ATOM 4955 C C . GLU B 1 251 ? 28.678 -37.917 -5.838 1.00 20.99 ? 320 GLU B C 1 ATOM 4956 O O . GLU B 1 251 ? 28.738 -37.878 -7.075 1.00 19.95 ? 320 GLU B O 1 ATOM 4957 C CB . GLU B 1 251 ? 29.614 -40.194 -5.297 1.00 21.10 ? 320 GLU B CB 1 ATOM 4958 C CG . GLU B 1 251 ? 28.334 -40.832 -4.722 1.00 22.42 ? 320 GLU B CG 1 ATOM 4959 C CD . GLU B 1 251 ? 27.887 -42.063 -5.472 1.00 25.21 ? 320 GLU B CD 1 ATOM 4960 O OE1 . GLU B 1 251 ? 28.240 -43.181 -5.049 1.00 26.82 ? 320 GLU B OE1 1 ATOM 4961 O OE2 . GLU B 1 251 ? 27.164 -41.920 -6.482 1.00 30.95 ? 320 GLU B OE2 1 ATOM 4962 N N . THR B 1 252 ? 27.698 -37.334 -5.125 1.00 20.61 ? 321 THR B N 1 ATOM 4963 C CA . THR B 1 252 ? 26.667 -36.521 -5.760 1.00 20.73 ? 321 THR B CA 1 ATOM 4964 C C . THR B 1 252 ? 27.184 -35.085 -5.941 1.00 20.71 ? 321 THR B C 1 ATOM 4965 O O . THR B 1 252 ? 26.839 -34.159 -5.166 1.00 20.87 ? 321 THR B O 1 ATOM 4966 C CB . THR B 1 252 ? 25.357 -36.542 -4.944 1.00 20.36 ? 321 THR B CB 1 ATOM 4967 O OG1 . THR B 1 252 ? 25.020 -37.892 -4.625 1.00 19.83 ? 321 THR B OG1 1 ATOM 4968 C CG2 . THR B 1 252 ? 24.205 -35.921 -5.749 1.00 22.54 ? 321 THR B CG2 1 ATOM 4969 N N . TYR B 1 253 ? 28.015 -34.903 -6.969 1.00 20.08 ? 322 TYR B N 1 ATOM 4970 C CA . TYR B 1 253 ? 28.596 -33.578 -7.260 1.00 19.48 ? 322 TYR B CA 1 ATOM 4971 C C . TYR B 1 253 ? 27.444 -32.628 -7.607 1.00 18.73 ? 322 TYR B C 1 ATOM 4972 O O . TYR B 1 253 ? 26.563 -32.991 -8.398 1.00 17.63 ? 322 TYR B O 1 ATOM 4973 C CB . TYR B 1 253 ? 29.636 -33.655 -8.382 1.00 19.09 ? 322 TYR B CB 1 ATOM 4974 C CG . TYR B 1 253 ? 30.534 -34.863 -8.256 1.00 19.55 ? 322 TYR B CG 1 ATOM 4975 C CD1 . TYR B 1 253 ? 31.079 -35.226 -7.007 1.00 18.60 ? 322 TYR B CD1 1 ATOM 4976 C CD2 . TYR B 1 253 ? 30.834 -35.655 -9.356 1.00 16.36 ? 322 TYR B CD2 1 ATOM 4977 C CE1 . TYR B 1 253 ? 31.881 -36.332 -6.870 1.00 17.35 ? 322 TYR B CE1 1 ATOM 4978 C CE2 . TYR B 1 253 ? 31.630 -36.759 -9.223 1.00 17.98 ? 322 TYR B CE2 1 ATOM 4979 C CZ . TYR B 1 253 ? 32.172 -37.102 -7.972 1.00 17.77 ? 322 TYR B CZ 1 ATOM 4980 O OH . TYR B 1 253 ? 32.984 -38.232 -7.840 1.00 15.35 ? 322 TYR B OH 1 ATOM 4981 N N . LEU B 1 254 ? 27.444 -31.452 -6.970 1.00 18.39 ? 323 LEU B N 1 ATOM 4982 C CA . LEU B 1 254 ? 26.306 -30.519 -6.996 1.00 17.94 ? 323 LEU B CA 1 ATOM 4983 C C . LEU B 1 254 ? 26.467 -29.360 -7.968 1.00 17.61 ? 323 LEU B C 1 ATOM 4984 O O . LEU B 1 254 ? 25.509 -28.635 -8.217 1.00 17.36 ? 323 LEU B O 1 ATOM 4985 C CB . LEU B 1 254 ? 26.042 -29.949 -5.585 1.00 18.11 ? 323 LEU B CB 1 ATOM 4986 C CG . LEU B 1 254 ? 25.498 -30.868 -4.473 1.00 17.80 ? 323 LEU B CG 1 ATOM 4987 C CD1 . LEU B 1 254 ? 25.600 -30.167 -3.113 1.00 17.86 ? 323 LEU B CD1 1 ATOM 4988 C CD2 . LEU B 1 254 ? 24.067 -31.300 -4.717 1.00 17.34 ? 323 LEU B CD2 1 ATOM 4989 N N . ASP B 1 255 ? 27.665 -29.172 -8.499 1.00 17.73 ? 324 ASP B N 1 ATOM 4990 C CA . ASP B 1 255 ? 27.932 -28.108 -9.475 1.00 18.75 ? 324 ASP B CA 1 ATOM 4991 C C . ASP B 1 255 ? 27.594 -28.539 -10.910 1.00 18.92 ? 324 ASP B C 1 ATOM 4992 O O . ASP B 1 255 ? 27.356 -29.720 -11.206 1.00 18.16 ? 324 ASP B O 1 ATOM 4993 C CB . ASP B 1 255 ? 29.414 -27.699 -9.411 1.00 19.11 ? 324 ASP B CB 1 ATOM 4994 C CG . ASP B 1 255 ? 29.630 -26.205 -9.517 1.00 18.85 ? 324 ASP B CG 1 ATOM 4995 O OD1 . ASP B 1 255 ? 28.641 -25.450 -9.623 1.00 16.35 ? 324 ASP B OD1 1 ATOM 4996 O OD2 . ASP B 1 255 ? 30.815 -25.805 -9.471 1.00 17.52 ? 324 ASP B OD2 1 ATOM 4997 N N . THR B 1 256 ? 27.564 -27.538 -11.777 1.00 19.84 ? 325 THR B N 1 ATOM 4998 C CA . THR B 1 256 ? 27.341 -27.692 -13.216 1.00 20.11 ? 325 THR B CA 1 ATOM 4999 C C . THR B 1 256 ? 28.249 -26.674 -13.884 1.00 20.92 ? 325 THR B C 1 ATOM 5000 O O . THR B 1 256 ? 28.184 -25.493 -13.532 1.00 20.87 ? 325 THR B O 1 ATOM 5001 C CB . THR B 1 256 ? 25.913 -27.336 -13.640 1.00 19.88 ? 325 THR B CB 1 ATOM 5002 O OG1 . THR B 1 256 ? 24.982 -28.089 -12.873 1.00 19.71 ? 325 THR B OG1 1 ATOM 5003 C CG2 . THR B 1 256 ? 25.694 -27.624 -15.157 1.00 18.98 ? 325 THR B CG2 1 ATOM 5004 N N . PRO B 1 257 ? 29.083 -27.116 -14.846 1.00 21.76 ? 326 PRO B N 1 ATOM 5005 C CA . PRO B 1 257 ? 29.182 -28.510 -15.296 1.00 22.29 ? 326 PRO B CA 1 ATOM 5006 C C . PRO B 1 257 ? 29.788 -29.429 -14.245 1.00 21.71 ? 326 PRO B C 1 ATOM 5007 O O . PRO B 1 257 ? 30.303 -28.955 -13.253 1.00 21.46 ? 326 PRO B O 1 ATOM 5008 C CB . PRO B 1 257 ? 30.115 -28.436 -16.509 1.00 21.66 ? 326 PRO B CB 1 ATOM 5009 C CG . PRO B 1 257 ? 30.194 -26.984 -16.850 1.00 22.98 ? 326 PRO B CG 1 ATOM 5010 C CD . PRO B 1 257 ? 30.034 -26.266 -15.571 1.00 22.12 ? 326 PRO B CD 1 ATOM 5011 N N . ARG B 1 258 ? 29.695 -30.732 -14.491 1.00 21.86 ? 327 ARG B N 1 ATOM 5012 C CA . ARG B 1 258 ? 30.248 -31.761 -13.611 1.00 21.97 ? 327 ARG B CA 1 ATOM 5013 C C . ARG B 1 258 ? 30.384 -33.051 -14.429 1.00 22.35 ? 327 ARG B C 1 ATOM 5014 O O . ARG B 1 258 ? 29.761 -33.170 -15.472 1.00 22.07 ? 327 ARG B O 1 ATOM 5015 C CB . ARG B 1 258 ? 29.361 -31.988 -12.377 1.00 21.17 ? 327 ARG B CB 1 ATOM 5016 C CG . ARG B 1 258 ? 27.951 -32.520 -12.697 1.00 20.91 ? 327 ARG B CG 1 ATOM 5017 C CD . ARG B 1 258 ? 27.149 -32.921 -11.455 1.00 18.19 ? 327 ARG B CD 1 ATOM 5018 N NE . ARG B 1 258 ? 25.807 -33.411 -11.802 1.00 18.05 ? 327 ARG B NE 1 ATOM 5019 C CZ . ARG B 1 258 ? 24.777 -32.641 -12.181 1.00 18.08 ? 327 ARG B CZ 1 ATOM 5020 N NH1 . ARG B 1 258 ? 24.896 -31.320 -12.270 1.00 17.36 ? 327 ARG B NH1 1 ATOM 5021 N NH2 . ARG B 1 258 ? 23.601 -33.190 -12.449 1.00 18.52 ? 327 ARG B NH2 1 ATOM 5022 N N . PRO B 1 259 ? 31.217 -34.002 -13.960 1.00 23.19 ? 328 PRO B N 1 ATOM 5023 C CA . PRO B 1 259 ? 31.337 -35.320 -14.562 1.00 23.45 ? 328 PRO B CA 1 ATOM 5024 C C . PRO B 1 259 ? 30.316 -36.262 -13.903 1.00 23.80 ? 328 PRO B C 1 ATOM 5025 O O . PRO B 1 259 ? 29.565 -35.811 -13.025 1.00 24.16 ? 328 PRO B O 1 ATOM 5026 C CB . PRO B 1 259 ? 32.765 -35.700 -14.214 1.00 23.29 ? 328 PRO B CB 1 ATOM 5027 C CG . PRO B 1 259 ? 32.941 -35.119 -12.822 1.00 23.64 ? 328 PRO B CG 1 ATOM 5028 C CD . PRO B 1 259 ? 32.114 -33.867 -12.791 1.00 23.23 ? 328 PRO B CD 1 ATOM 5029 N N . ASP B 1 260 ? 30.275 -37.530 -14.318 1.00 23.49 ? 329 ASP B N 1 ATOM 5030 C CA . ASP B 1 260 ? 29.313 -38.494 -13.781 1.00 23.60 ? 329 ASP B CA 1 ATOM 5031 C C . ASP B 1 260 ? 29.560 -38.712 -12.289 1.00 23.94 ? 329 ASP B C 1 ATOM 5032 O O . ASP B 1 260 ? 30.700 -38.750 -11.842 1.00 24.47 ? 329 ASP B O 1 ATOM 5033 C CB . ASP B 1 260 ? 29.384 -39.841 -14.538 1.00 23.61 ? 329 ASP B CB 1 ATOM 5034 C CG . ASP B 1 260 ? 28.966 -39.724 -16.017 1.00 24.11 ? 329 ASP B CG 1 ATOM 5035 O OD1 . ASP B 1 260 ? 28.514 -38.649 -16.436 1.00 24.24 ? 329 ASP B OD1 1 ATOM 5036 O OD2 . ASP B 1 260 ? 29.103 -40.702 -16.783 1.00 28.43 ? 329 ASP B OD2 1 ATOM 5037 N N . ASP B 1 261 ? 28.489 -38.833 -11.521 1.00 23.97 ? 330 ASP B N 1 ATOM 5038 C CA . ASP B 1 261 ? 28.598 -39.024 -10.076 1.00 24.25 ? 330 ASP B CA 1 ATOM 5039 C C . ASP B 1 261 ? 29.608 -40.117 -9.763 1.00 24.27 ? 330 ASP B C 1 ATOM 5040 O O . ASP B 1 261 ? 29.578 -41.169 -10.371 1.00 24.93 ? 330 ASP B O 1 ATOM 5041 C CB . ASP B 1 261 ? 27.252 -39.469 -9.503 1.00 23.95 ? 330 ASP B CB 1 ATOM 5042 C CG . ASP B 1 261 ? 26.227 -38.391 -9.527 1.00 24.19 ? 330 ASP B CG 1 ATOM 5043 O OD1 . ASP B 1 261 ? 26.567 -37.191 -9.702 1.00 24.44 ? 330 ASP B OD1 1 ATOM 5044 O OD2 . ASP B 1 261 ? 25.061 -38.752 -9.347 1.00 23.02 ? 330 ASP B OD2 1 ATOM 5045 N N . GLY B 1 262 ? 30.493 -39.867 -8.823 1.00 24.52 ? 331 GLY B N 1 ATOM 5046 C CA . GLY B 1 262 ? 31.439 -40.881 -8.367 1.00 25.16 ? 331 GLY B CA 1 ATOM 5047 C C . GLY B 1 262 ? 32.655 -41.142 -9.236 1.00 25.65 ? 331 GLY B C 1 ATOM 5048 O O . GLY B 1 262 ? 33.396 -42.087 -8.959 1.00 26.37 ? 331 GLY B O 1 ATOM 5049 N N . SER B 1 263 ? 32.873 -40.327 -10.273 1.00 25.38 ? 332 SER B N 1 ATOM 5050 C CA . SER B 1 263 ? 34.005 -40.516 -11.184 1.00 25.10 ? 332 SER B CA 1 ATOM 5051 C C . SER B 1 263 ? 35.211 -39.651 -10.772 1.00 25.68 ? 332 SER B C 1 ATOM 5052 O O . SER B 1 263 ? 36.239 -39.645 -11.456 1.00 23.83 ? 332 SER B O 1 ATOM 5053 C CB . SER B 1 263 ? 33.607 -40.207 -12.621 1.00 24.41 ? 332 SER B CB 1 ATOM 5054 O OG . SER B 1 263 ? 33.371 -38.827 -12.794 1.00 23.04 ? 332 SER B OG 1 ATOM 5055 N N . ILE B 1 264 ? 35.093 -38.919 -9.657 1.00 26.31 ? 333 ILE B N 1 ATOM 5056 C CA . ILE B 1 264 ? 36.270 -38.210 -9.141 1.00 26.92 ? 333 ILE B CA 1 ATOM 5057 C C . ILE B 1 264 ? 36.983 -39.177 -8.215 1.00 27.73 ? 333 ILE B C 1 ATOM 5058 O O . ILE B 1 264 ? 36.465 -39.531 -7.146 1.00 28.41 ? 333 ILE B O 1 ATOM 5059 C CB . ILE B 1 264 ? 35.941 -36.865 -8.447 1.00 26.92 ? 333 ILE B CB 1 ATOM 5060 C CG1 . ILE B 1 264 ? 35.494 -35.839 -9.492 1.00 25.43 ? 333 ILE B CG1 1 ATOM 5061 C CG2 . ILE B 1 264 ? 37.152 -36.335 -7.681 1.00 25.48 ? 333 ILE B CG2 1 ATOM 5062 C CD1 . ILE B 1 264 ? 34.753 -34.644 -8.912 1.00 22.77 ? 333 ILE B CD1 1 ATOM 5063 N N . THR B 1 265 ? 38.156 -39.612 -8.670 1.00 28.67 ? 334 THR B N 1 ATOM 5064 C CA . THR B 1 265 ? 38.997 -40.578 -7.969 1.00 29.50 ? 334 THR B CA 1 ATOM 5065 C C . THR B 1 265 ? 39.913 -39.822 -7.011 1.00 29.50 ? 334 THR B C 1 ATOM 5066 O O . THR B 1 265 ? 40.320 -38.703 -7.306 1.00 29.94 ? 334 THR B O 1 ATOM 5067 C CB . THR B 1 265 ? 39.874 -41.383 -8.981 1.00 29.80 ? 334 THR B CB 1 ATOM 5068 O OG1 . THR B 1 265 ? 40.969 -40.572 -9.428 1.00 31.09 ? 334 THR B OG1 1 ATOM 5069 C CG2 . THR B 1 265 ? 39.051 -41.835 -10.197 1.00 29.20 ? 334 THR B CG2 1 ATOM 5070 N N . GLY B 1 266 ? 40.249 -40.440 -5.883 1.00 29.51 ? 335 GLY B N 1 ATOM 5071 C CA . GLY B 1 266 ? 41.069 -39.798 -4.851 1.00 29.36 ? 335 GLY B CA 1 ATOM 5072 C C . GLY B 1 266 ? 40.240 -39.620 -3.593 1.00 29.52 ? 335 GLY B C 1 ATOM 5073 O O . GLY B 1 266 ? 39.039 -39.848 -3.627 1.00 29.45 ? 335 GLY B O 1 ATOM 5074 N N . PRO B 1 267 ? 40.870 -39.210 -2.474 1.00 29.87 ? 336 PRO B N 1 ATOM 5075 C CA . PRO B 1 267 ? 40.140 -39.037 -1.221 1.00 30.08 ? 336 PRO B CA 1 ATOM 5076 C C . PRO B 1 267 ? 39.296 -37.763 -1.283 1.00 30.36 ? 336 PRO B C 1 ATOM 5077 O O . PRO B 1 267 ? 39.348 -37.042 -2.281 1.00 30.76 ? 336 PRO B O 1 ATOM 5078 C CB . PRO B 1 267 ? 41.262 -38.877 -0.200 1.00 30.15 ? 336 PRO B CB 1 ATOM 5079 C CG . PRO B 1 267 ? 42.273 -38.090 -0.938 1.00 30.07 ? 336 PRO B CG 1 ATOM 5080 C CD . PRO B 1 267 ? 42.235 -38.661 -2.367 1.00 30.05 ? 336 PRO B CD 1 ATOM 5081 N N . CYS B 1 268 ? 38.550 -37.475 -0.224 1.00 30.39 ? 337 CYS B N 1 ATOM 5082 C CA . CYS B 1 268 ? 37.544 -36.395 -0.234 1.00 30.49 ? 337 CYS B CA 1 ATOM 5083 C C . CYS B 1 268 ? 37.976 -35.062 -0.872 1.00 30.03 ? 337 CYS B C 1 ATOM 5084 O O . CYS B 1 268 ? 37.162 -34.371 -1.498 1.00 29.51 ? 337 CYS B O 1 ATOM 5085 C CB . CYS B 1 268 ? 37.043 -36.125 1.192 1.00 29.93 ? 337 CYS B CB 1 ATOM 5086 S SG . CYS B 1 268 ? 36.068 -37.485 1.884 1.00 32.09 ? 337 CYS B SG 1 ATOM 5087 N N . GLU B 1 269 ? 39.239 -34.703 -0.711 1.00 29.60 ? 338 GLU B N 1 ATOM 5088 C CA . GLU B 1 269 ? 39.694 -33.411 -1.160 1.00 30.00 ? 338 GLU B CA 1 ATOM 5089 C C . GLU B 1 269 ? 40.134 -33.319 -2.638 1.00 29.56 ? 338 GLU B C 1 ATOM 5090 O O . GLU B 1 269 ? 40.536 -32.255 -3.072 1.00 29.95 ? 338 GLU B O 1 ATOM 5091 C CB . GLU B 1 269 ? 40.788 -32.900 -0.211 1.00 30.59 ? 338 GLU B CB 1 ATOM 5092 C CG . GLU B 1 269 ? 42.162 -33.562 -0.338 1.00 32.50 ? 338 GLU B CG 1 ATOM 5093 C CD . GLU B 1 269 ? 42.376 -34.753 0.581 1.00 34.82 ? 338 GLU B CD 1 ATOM 5094 O OE1 . GLU B 1 269 ? 41.398 -35.376 1.054 1.00 36.08 ? 338 GLU B OE1 1 ATOM 5095 O OE2 . GLU B 1 269 ? 43.561 -35.077 0.806 1.00 38.73 ? 338 GLU B OE2 1 ATOM 5096 N N . SER B 1 270 ? 40.045 -34.394 -3.412 1.00 29.11 ? 339 SER B N 1 ATOM 5097 C CA . SER B 1 270 ? 40.496 -34.364 -4.814 1.00 29.14 ? 339 SER B CA 1 ATOM 5098 C C . SER B 1 270 ? 39.598 -33.517 -5.713 1.00 28.76 ? 339 SER B C 1 ATOM 5099 O O . SER B 1 270 ? 38.399 -33.548 -5.564 1.00 29.18 ? 339 SER B O 1 ATOM 5100 C CB . SER B 1 270 ? 40.538 -35.782 -5.378 1.00 29.18 ? 339 SER B CB 1 ATOM 5101 O OG . SER B 1 270 ? 41.452 -36.581 -4.670 1.00 30.44 ? 339 SER B OG 1 ATOM 5102 N N . ASN B 1 271 ? 40.184 -32.796 -6.666 1.00 28.79 ? 340 ASN B N 1 ATOM 5103 C CA . ASN B 1 271 ? 39.439 -31.867 -7.530 1.00 28.70 ? 340 ASN B CA 1 ATOM 5104 C C . ASN B 1 271 ? 38.441 -32.555 -8.529 1.00 28.52 ? 340 ASN B C 1 ATOM 5105 O O . ASN B 1 271 ? 37.291 -32.132 -8.602 1.00 27.99 ? 340 ASN B O 1 ATOM 5106 C CB . ASN B 1 271 ? 40.390 -30.875 -8.222 1.00 28.86 ? 340 ASN B CB 1 ATOM 5107 C CG . ASN B 1 271 ? 40.896 -29.734 -7.296 1.00 29.66 ? 340 ASN B CG 1 ATOM 5108 O OD1 . ASN B 1 271 ? 40.500 -29.592 -6.136 1.00 30.65 ? 340 ASN B OD1 1 ATOM 5109 N ND2 . ASN B 1 271 ? 41.820 -28.936 -7.831 1.00 31.79 ? 340 ASN B ND2 1 ATOM 5110 N N . GLY B 1 272 ? 38.824 -33.493 -9.390 1.00 28.69 ? 341 GLY B N 1 ATOM 5111 C CA . GLY B 1 272 ? 39.919 -33.382 -10.301 1.00 29.42 ? 341 GLY B CA 1 ATOM 5112 C C . GLY B 1 272 ? 39.335 -32.742 -11.559 1.00 29.80 ? 341 GLY B C 1 ATOM 5113 O O . GLY B 1 272 ? 39.489 -31.537 -11.761 1.00 30.41 ? 341 GLY B O 1 ATOM 5114 N N . ASP B 1 273 ? 38.600 -33.508 -12.363 1.00 30.57 ? 342 ASP B N 1 ATOM 5115 C CA . ASP B 1 273 ? 38.198 -33.061 -13.737 1.00 31.59 ? 342 ASP B CA 1 ATOM 5116 C C . ASP B 1 273 ? 36.769 -32.551 -14.030 1.00 31.46 ? 342 ASP B C 1 ATOM 5117 O O . ASP B 1 273 ? 35.875 -32.651 -13.196 1.00 31.37 ? 342 ASP B O 1 ATOM 5118 C CB . ASP B 1 273 ? 38.535 -34.152 -14.751 1.00 32.10 ? 342 ASP B CB 1 ATOM 5119 C CG . ASP B 1 273 ? 39.715 -33.790 -15.575 1.00 34.17 ? 342 ASP B CG 1 ATOM 5120 O OD1 . ASP B 1 273 ? 39.603 -32.778 -16.307 1.00 37.92 ? 342 ASP B OD1 1 ATOM 5121 O OD2 . ASP B 1 273 ? 40.753 -34.482 -15.464 1.00 37.05 ? 342 ASP B OD2 1 ATOM 5122 N N . LYS B 1 274 ? 36.584 -32.055 -15.267 1.00 31.79 ? 343 LYS B N 1 ATOM 5123 C CA . LYS B 1 274 ? 35.421 -31.246 -15.687 1.00 31.53 ? 343 LYS B CA 1 ATOM 5124 C C . LYS B 1 274 ? 34.772 -30.503 -14.517 1.00 31.00 ? 343 LYS B C 1 ATOM 5125 O O . LYS B 1 274 ? 33.584 -30.696 -14.205 1.00 31.05 ? 343 LYS B O 1 ATOM 5126 C CB . LYS B 1 274 ? 34.386 -32.067 -16.477 1.00 32.18 ? 343 LYS B CB 1 ATOM 5127 C CG . LYS B 1 274 ? 33.192 -31.187 -17.042 1.00 33.70 ? 343 LYS B CG 1 ATOM 5128 C CD . LYS B 1 274 ? 32.830 -31.488 -18.528 1.00 34.82 ? 343 LYS B CD 1 ATOM 5129 C CE . LYS B 1 274 ? 31.365 -31.140 -18.889 1.00 34.68 ? 343 LYS B CE 1 ATOM 5130 N NZ . LYS B 1 274 ? 30.299 -31.950 -18.145 1.00 31.75 ? 343 LYS B NZ 1 ATOM 5131 N N . GLY B 1 275 ? 35.585 -29.658 -13.879 1.00 29.82 ? 344 GLY B N 1 ATOM 5132 C CA . GLY B 1 275 ? 35.165 -28.829 -12.763 1.00 28.68 ? 344 GLY B CA 1 ATOM 5133 C C . GLY B 1 275 ? 35.257 -27.328 -12.977 1.00 27.58 ? 344 GLY B C 1 ATOM 5134 O O . GLY B 1 275 ? 34.885 -26.580 -12.093 1.00 28.13 ? 344 GLY B O 1 ATOM 5135 N N . SER B 1 276 ? 35.747 -26.866 -14.123 1.00 26.58 ? 345 SER B N 1 ATOM 5136 C CA . SER B 1 276 ? 35.692 -25.432 -14.431 1.00 25.76 ? 345 SER B CA 1 ATOM 5137 C C . SER B 1 276 ? 34.243 -24.981 -14.721 1.00 24.27 ? 345 SER B C 1 ATOM 5138 O O . SER B 1 276 ? 33.371 -25.767 -15.086 1.00 24.41 ? 345 SER B O 1 ATOM 5139 C CB . SER B 1 276 ? 36.653 -25.052 -15.580 1.00 26.21 ? 345 SER B CB 1 ATOM 5140 O OG . SER B 1 276 ? 36.440 -25.852 -16.726 1.00 26.90 ? 345 SER B OG 1 ATOM 5141 N N . GLY B 1 277 ? 33.993 -23.701 -14.531 1.00 22.61 ? 346 GLY B N 1 ATOM 5142 C CA . GLY B 1 277 ? 32.644 -23.216 -14.459 1.00 21.45 ? 346 GLY B CA 1 ATOM 5143 C C . GLY B 1 277 ? 32.007 -23.618 -13.134 1.00 21.03 ? 346 GLY B C 1 ATOM 5144 O O . GLY B 1 277 ? 32.675 -24.116 -12.199 1.00 20.17 ? 346 GLY B O 1 ATOM 5145 N N . GLY B 1 278 ? 30.701 -23.400 -13.064 1.00 19.78 ? 347 GLY B N 1 ATOM 5146 C CA . GLY B 1 278 ? 29.959 -23.660 -11.863 1.00 18.63 ? 347 GLY B CA 1 ATOM 5147 C C . GLY B 1 278 ? 28.597 -22.996 -11.926 1.00 18.03 ? 347 GLY B C 1 ATOM 5148 O O . GLY B 1 278 ? 28.182 -22.436 -12.982 1.00 17.32 ? 347 GLY B O 1 ATOM 5149 N N . ILE B 1 279 ? 27.904 -23.076 -10.787 1.00 16.18 ? 348 ILE B N 1 ATOM 5150 C CA . ILE B 1 279 ? 26.617 -22.451 -10.602 1.00 14.78 ? 348 ILE B CA 1 ATOM 5151 C C . ILE B 1 279 ? 26.317 -22.314 -9.072 1.00 14.79 ? 348 ILE B C 1 ATOM 5152 O O . ILE B 1 279 ? 26.817 -23.107 -8.236 1.00 13.02 ? 348 ILE B O 1 ATOM 5153 C CB . ILE B 1 279 ? 25.551 -23.285 -11.342 1.00 14.22 ? 348 ILE B CB 1 ATOM 5154 C CG1 . ILE B 1 279 ? 24.220 -22.530 -11.506 1.00 13.27 ? 348 ILE B CG1 1 ATOM 5155 C CG2 . ILE B 1 279 ? 25.361 -24.635 -10.668 1.00 12.50 ? 348 ILE B CG2 1 ATOM 5156 C CD1 . ILE B 1 279 ? 23.241 -23.209 -12.563 1.00 9.64 ? 348 ILE B CD1 1 ATOM 5157 N N . LYS B 1 280 ? 25.529 -21.298 -8.716 1.00 14.35 ? 349 LYS B N 1 ATOM 5158 C CA . LYS B 1 280 ? 25.061 -21.172 -7.338 1.00 15.36 ? 349 LYS B CA 1 ATOM 5159 C C . LYS B 1 280 ? 24.057 -22.295 -7.090 1.00 15.69 ? 349 LYS B C 1 ATOM 5160 O O . LYS B 1 280 ? 23.296 -22.666 -7.998 1.00 15.11 ? 349 LYS B O 1 ATOM 5161 C CB . LYS B 1 280 ? 24.421 -19.819 -7.076 1.00 15.42 ? 349 LYS B CB 1 ATOM 5162 C CG . LYS B 1 280 ? 24.117 -19.572 -5.596 1.00 14.72 ? 349 LYS B CG 1 ATOM 5163 C CD . LYS B 1 280 ? 23.476 -18.230 -5.400 1.00 14.93 ? 349 LYS B CD 1 ATOM 5164 C CE . LYS B 1 280 ? 22.968 -18.061 -3.975 1.00 16.20 ? 349 LYS B CE 1 ATOM 5165 N NZ . LYS B 1 280 ? 24.024 -18.291 -2.972 1.00 16.79 ? 349 LYS B NZ 1 ATOM 5166 N N . GLY B 1 281 ? 24.093 -22.843 -5.875 1.00 15.78 ? 350 GLY B N 1 ATOM 5167 C CA . GLY B 1 281 ? 23.316 -24.027 -5.530 1.00 16.15 ? 350 GLY B CA 1 ATOM 5168 C C . GLY B 1 281 ? 22.536 -23.857 -4.239 1.00 16.56 ? 350 GLY B C 1 ATOM 5169 O O . GLY B 1 281 ? 23.033 -23.242 -3.276 1.00 15.99 ? 350 GLY B O 1 ATOM 5170 N N . GLY B 1 282 ? 21.304 -24.376 -4.245 1.00 15.86 ? 351 GLY B N 1 ATOM 5171 C CA . GLY B 1 282 ? 20.435 -24.283 -3.118 1.00 15.30 ? 351 GLY B CA 1 ATOM 5172 C C . GLY B 1 282 ? 20.954 -25.156 -2.003 1.00 15.44 ? 351 GLY B C 1 ATOM 5173 O O . GLY B 1 282 ? 21.540 -26.210 -2.268 1.00 13.82 ? 351 GLY B O 1 ATOM 5174 N N . PHE B 1 283 ? 20.791 -24.688 -0.760 1.00 15.76 ? 352 PHE B N 1 ATOM 5175 C CA . PHE B 1 283 ? 21.171 -25.479 0.423 1.00 16.67 ? 352 PHE B CA 1 ATOM 5176 C C . PHE B 1 283 ? 20.387 -24.947 1.591 1.00 16.49 ? 352 PHE B C 1 ATOM 5177 O O . PHE B 1 283 ? 20.277 -23.735 1.732 1.00 16.81 ? 352 PHE B O 1 ATOM 5178 C CB . PHE B 1 283 ? 22.681 -25.393 0.706 1.00 17.16 ? 352 PHE B CB 1 ATOM 5179 C CG . PHE B 1 283 ? 23.110 -25.961 2.070 1.00 19.21 ? 352 PHE B CG 1 ATOM 5180 C CD1 . PHE B 1 283 ? 22.760 -27.244 2.459 1.00 19.88 ? 352 PHE B CD1 1 ATOM 5181 C CD2 . PHE B 1 283 ? 23.900 -25.203 2.950 1.00 21.11 ? 352 PHE B CD2 1 ATOM 5182 C CE1 . PHE B 1 283 ? 23.169 -27.761 3.703 1.00 20.84 ? 352 PHE B CE1 1 ATOM 5183 C CE2 . PHE B 1 283 ? 24.313 -25.719 4.189 1.00 20.50 ? 352 PHE B CE2 1 ATOM 5184 C CZ . PHE B 1 283 ? 23.948 -26.993 4.560 1.00 20.52 ? 352 PHE B CZ 1 ATOM 5185 N N . VAL B 1 284 ? 19.829 -25.848 2.405 1.00 16.33 ? 353 VAL B N 1 ATOM 5186 C CA . VAL B 1 284 ? 19.056 -25.468 3.566 1.00 15.30 ? 353 VAL B CA 1 ATOM 5187 C C . VAL B 1 284 ? 18.937 -26.559 4.635 1.00 15.62 ? 353 VAL B C 1 ATOM 5188 O O . VAL B 1 284 ? 18.915 -27.757 4.345 1.00 15.24 ? 353 VAL B O 1 ATOM 5189 C CB . VAL B 1 284 ? 17.645 -24.949 3.148 1.00 15.69 ? 353 VAL B CB 1 ATOM 5190 C CG1 . VAL B 1 284 ? 16.669 -26.104 2.855 1.00 13.02 ? 353 VAL B CG1 1 ATOM 5191 C CG2 . VAL B 1 284 ? 17.091 -24.006 4.241 1.00 14.02 ? 353 VAL B CG2 1 ATOM 5192 N N . HIS B 1 285 ? 18.828 -26.123 5.888 1.00 16.52 ? 354 HIS B N 1 ATOM 5193 C CA . HIS B 1 285 ? 18.795 -27.042 7.036 1.00 16.47 ? 354 HIS B CA 1 ATOM 5194 C C . HIS B 1 285 ? 17.389 -27.350 7.510 1.00 17.52 ? 354 HIS B C 1 ATOM 5195 O O . HIS B 1 285 ? 16.541 -26.443 7.624 1.00 18.04 ? 354 HIS B O 1 ATOM 5196 C CB . HIS B 1 285 ? 19.597 -26.447 8.176 1.00 16.57 ? 354 HIS B CB 1 ATOM 5197 C CG . HIS B 1 285 ? 21.041 -26.273 7.848 1.00 14.59 ? 354 HIS B CG 1 ATOM 5198 N ND1 . HIS B 1 285 ? 21.547 -25.103 7.325 1.00 16.22 ? 354 HIS B ND1 1 ATOM 5199 C CD2 . HIS B 1 285 ? 22.085 -27.126 7.946 1.00 12.89 ? 354 HIS B CD2 1 ATOM 5200 C CE1 . HIS B 1 285 ? 22.848 -25.238 7.130 1.00 14.68 ? 354 HIS B CE1 1 ATOM 5201 N NE2 . HIS B 1 285 ? 23.198 -26.457 7.497 1.00 12.83 ? 354 HIS B NE2 1 ATOM 5202 N N . GLN B 1 286 ? 17.140 -28.635 7.750 1.00 18.33 ? 355 GLN B N 1 ATOM 5203 C CA . GLN B 1 286 ? 15.997 -29.094 8.529 1.00 19.10 ? 355 GLN B CA 1 ATOM 5204 C C . GLN B 1 286 ? 16.524 -29.480 9.900 1.00 19.56 ? 355 GLN B C 1 ATOM 5205 O O . GLN B 1 286 ? 17.078 -30.540 10.054 1.00 19.52 ? 355 GLN B O 1 ATOM 5206 C CB . GLN B 1 286 ? 15.383 -30.306 7.842 1.00 19.37 ? 355 GLN B CB 1 ATOM 5207 C CG . GLN B 1 286 ? 14.149 -30.854 8.568 1.00 21.01 ? 355 GLN B CG 1 ATOM 5208 C CD . GLN B 1 286 ? 13.599 -32.093 7.925 1.00 20.62 ? 355 GLN B CD 1 ATOM 5209 O OE1 . GLN B 1 286 ? 14.263 -32.729 7.115 1.00 22.29 ? 355 GLN B OE1 1 ATOM 5210 N NE2 . GLN B 1 286 ? 12.358 -32.423 8.251 1.00 20.43 ? 355 GLN B NE2 1 ATOM 5211 N N . ARG B 1 287 ? 16.399 -28.601 10.883 1.00 21.39 ? 356 ARG B N 1 ATOM 5212 C CA . ARG B 1 287 ? 17.014 -28.816 12.207 1.00 22.08 ? 356 ARG B CA 1 ATOM 5213 C C . ARG B 1 287 ? 16.033 -29.469 13.139 1.00 23.64 ? 356 ARG B C 1 ATOM 5214 O O . ARG B 1 287 ? 14.994 -28.894 13.451 1.00 24.11 ? 356 ARG B O 1 ATOM 5215 C CB . ARG B 1 287 ? 17.469 -27.497 12.829 1.00 21.88 ? 356 ARG B CB 1 ATOM 5216 C CG . ARG B 1 287 ? 18.543 -26.760 12.032 1.00 19.88 ? 356 ARG B CG 1 ATOM 5217 C CD . ARG B 1 287 ? 18.939 -25.450 12.663 1.00 16.13 ? 356 ARG B CD 1 ATOM 5218 N NE . ARG B 1 287 ? 17.826 -24.512 12.774 1.00 15.57 ? 356 ARG B NE 1 ATOM 5219 C CZ . ARG B 1 287 ? 17.355 -23.747 11.780 1.00 17.62 ? 356 ARG B CZ 1 ATOM 5220 N NH1 . ARG B 1 287 ? 17.878 -23.793 10.547 1.00 18.18 ? 356 ARG B NH1 1 ATOM 5221 N NH2 . ARG B 1 287 ? 16.328 -22.939 12.019 1.00 16.73 ? 356 ARG B NH2 1 ATOM 5222 N N . MET B 1 288 ? 16.365 -30.669 13.592 1.00 25.74 ? 357 MET B N 1 ATOM 5223 C CA . MET B 1 288 ? 15.488 -31.432 14.481 1.00 27.08 ? 357 MET B CA 1 ATOM 5224 C C . MET B 1 288 ? 16.160 -31.657 15.812 1.00 28.10 ? 357 MET B C 1 ATOM 5225 O O . MET B 1 288 ? 17.306 -31.268 15.985 1.00 28.04 ? 357 MET B O 1 ATOM 5226 C CB . MET B 1 288 ? 15.137 -32.749 13.817 1.00 27.49 ? 357 MET B CB 1 ATOM 5227 C CG . MET B 1 288 ? 14.414 -32.544 12.478 1.00 28.55 ? 357 MET B CG 1 ATOM 5228 S SD . MET B 1 288 ? 14.444 -34.052 11.504 1.00 33.14 ? 357 MET B SD 1 ATOM 5229 C CE . MET B 1 288 ? 16.138 -34.023 10.909 1.00 32.38 ? 357 MET B CE 1 ATOM 5230 N N . ALA B 1 289 ? 15.451 -32.292 16.748 1.00 29.72 ? 358 ALA B N 1 ATOM 5231 C CA . ALA B 1 289 ? 15.917 -32.386 18.147 1.00 30.74 ? 358 ALA B CA 1 ATOM 5232 C C . ALA B 1 289 ? 17.217 -33.183 18.307 1.00 31.61 ? 358 ALA B C 1 ATOM 5233 O O . ALA B 1 289 ? 18.139 -32.705 18.966 1.00 32.75 ? 358 ALA B O 1 ATOM 5234 C CB . ALA B 1 289 ? 14.815 -32.939 19.059 1.00 30.75 ? 358 ALA B CB 1 ATOM 5235 N N . SER B 1 290 ? 17.311 -34.375 17.717 1.00 32.27 ? 359 SER B N 1 ATOM 5236 C CA . SER B 1 290 ? 18.597 -35.100 17.692 1.00 32.63 ? 359 SER B CA 1 ATOM 5237 C C . SER B 1 290 ? 18.973 -35.612 16.298 1.00 32.25 ? 359 SER B C 1 ATOM 5238 O O . SER B 1 290 ? 19.491 -36.716 16.151 1.00 32.66 ? 359 SER B O 1 ATOM 5239 C CB . SER B 1 290 ? 18.603 -36.258 18.709 1.00 33.29 ? 359 SER B CB 1 ATOM 5240 O OG . SER B 1 290 ? 18.329 -35.795 20.028 1.00 34.37 ? 359 SER B OG 1 ATOM 5241 N N . LYS B 1 291 ? 18.724 -34.794 15.282 1.00 31.57 ? 360 LYS B N 1 ATOM 5242 C CA . LYS B 1 291 ? 19.080 -35.112 13.897 1.00 30.78 ? 360 LYS B CA 1 ATOM 5243 C C . LYS B 1 291 ? 19.175 -33.826 13.095 1.00 29.31 ? 360 LYS B C 1 ATOM 5244 O O . LYS B 1 291 ? 18.544 -32.852 13.429 1.00 29.74 ? 360 LYS B O 1 ATOM 5245 C CB . LYS B 1 291 ? 17.999 -35.993 13.302 1.00 31.13 ? 360 LYS B CB 1 ATOM 5246 C CG . LYS B 1 291 ? 18.385 -36.669 12.027 1.00 32.27 ? 360 LYS B CG 1 ATOM 5247 C CD . LYS B 1 291 ? 17.328 -37.674 11.597 1.00 35.29 ? 360 LYS B CD 1 ATOM 5248 C CE . LYS B 1 291 ? 17.429 -38.981 12.368 1.00 36.66 ? 360 LYS B CE 1 ATOM 5249 N NZ . LYS B 1 291 ? 16.289 -39.878 12.044 1.00 38.61 ? 360 LYS B NZ 1 ATOM 5250 N N . ILE B 1 292 ? 19.960 -33.804 12.038 1.00 28.19 ? 361 ILE B N 1 ATOM 5251 C CA . ILE B 1 292 ? 19.918 -32.664 11.119 1.00 27.30 ? 361 ILE B CA 1 ATOM 5252 C C . ILE B 1 292 ? 19.829 -33.132 9.669 1.00 25.61 ? 361 ILE B C 1 ATOM 5253 O O . ILE B 1 292 ? 20.550 -34.024 9.252 1.00 25.82 ? 361 ILE B O 1 ATOM 5254 C CB . ILE B 1 292 ? 21.126 -31.742 11.323 1.00 27.56 ? 361 ILE B CB 1 ATOM 5255 C CG1 . ILE B 1 292 ? 20.864 -30.376 10.694 1.00 29.55 ? 361 ILE B CG1 1 ATOM 5256 C CG2 . ILE B 1 292 ? 22.403 -32.355 10.764 1.00 27.35 ? 361 ILE B CG2 1 ATOM 5257 C CD1 . ILE B 1 292 ? 21.980 -29.393 10.925 1.00 31.56 ? 361 ILE B CD1 1 ATOM 5258 N N . GLY B 1 293 ? 18.931 -32.531 8.906 1.00 23.75 ? 362 GLY B N 1 ATOM 5259 C CA . GLY B 1 293 ? 18.815 -32.831 7.482 1.00 22.33 ? 362 GLY B CA 1 ATOM 5260 C C . GLY B 1 293 ? 19.483 -31.760 6.638 1.00 21.30 ? 362 GLY B C 1 ATOM 5261 O O . GLY B 1 293 ? 19.355 -30.559 6.890 1.00 20.71 ? 362 GLY B O 1 ATOM 5262 N N . ARG B 1 294 ? 20.210 -32.185 5.630 1.00 20.34 ? 363 ARG B N 1 ATOM 5263 C CA . ARG B 1 294 ? 20.806 -31.232 4.714 1.00 19.64 ? 363 ARG B CA 1 ATOM 5264 C C . ARG B 1 294 ? 20.130 -31.403 3.376 1.00 18.00 ? 363 ARG B C 1 ATOM 5265 O O . ARG B 1 294 ? 20.166 -32.472 2.795 1.00 16.77 ? 363 ARG B O 1 ATOM 5266 C CB . ARG B 1 294 ? 22.325 -31.420 4.626 1.00 19.87 ? 363 ARG B CB 1 ATOM 5267 C CG . ARG B 1 294 ? 23.001 -31.021 5.946 1.00 21.80 ? 363 ARG B CG 1 ATOM 5268 C CD . ARG B 1 294 ? 24.506 -30.918 5.865 1.00 22.73 ? 363 ARG B CD 1 ATOM 5269 N NE . ARG B 1 294 ? 25.038 -30.558 7.184 1.00 25.38 ? 363 ARG B NE 1 ATOM 5270 C CZ . ARG B 1 294 ? 25.230 -31.409 8.198 1.00 27.71 ? 363 ARG B CZ 1 ATOM 5271 N NH1 . ARG B 1 294 ? 24.946 -32.715 8.087 1.00 29.00 ? 363 ARG B NH1 1 ATOM 5272 N NH2 . ARG B 1 294 ? 25.712 -30.952 9.342 1.00 27.69 ? 363 ARG B NH2 1 ATOM 5273 N N . TRP B 1 295 ? 19.496 -30.331 2.920 1.00 16.98 ? 364 TRP B N 1 ATOM 5274 C CA . TRP B 1 295 ? 18.807 -30.316 1.637 1.00 16.47 ? 364 TRP B CA 1 ATOM 5275 C C . TRP B 1 295 ? 19.614 -29.557 0.575 1.00 15.66 ? 364 TRP B C 1 ATOM 5276 O O . TRP B 1 295 ? 20.149 -28.499 0.839 1.00 16.74 ? 364 TRP B O 1 ATOM 5277 C CB . TRP B 1 295 ? 17.399 -29.717 1.807 1.00 16.00 ? 364 TRP B CB 1 ATOM 5278 C CG . TRP B 1 295 ? 16.487 -30.566 2.641 1.00 16.33 ? 364 TRP B CG 1 ATOM 5279 C CD1 . TRP B 1 295 ? 16.395 -30.578 4.021 1.00 18.34 ? 364 TRP B CD1 1 ATOM 5280 C CD2 . TRP B 1 295 ? 15.551 -31.539 2.175 1.00 17.38 ? 364 TRP B CD2 1 ATOM 5281 N NE1 . TRP B 1 295 ? 15.451 -31.489 4.422 1.00 18.48 ? 364 TRP B NE1 1 ATOM 5282 C CE2 . TRP B 1 295 ? 14.915 -32.090 3.317 1.00 14.95 ? 364 TRP B CE2 1 ATOM 5283 C CE3 . TRP B 1 295 ? 15.160 -31.982 0.893 1.00 16.37 ? 364 TRP B CE3 1 ATOM 5284 C CZ2 . TRP B 1 295 ? 13.949 -33.072 3.231 1.00 14.77 ? 364 TRP B CZ2 1 ATOM 5285 C CZ3 . TRP B 1 295 ? 14.193 -32.966 0.809 1.00 16.26 ? 364 TRP B CZ3 1 ATOM 5286 C CH2 . TRP B 1 295 ? 13.580 -33.487 1.978 1.00 17.31 ? 364 TRP B CH2 1 ATOM 5287 N N . TYR B 1 296 ? 19.646 -30.080 -0.639 1.00 14.93 ? 365 TYR B N 1 ATOM 5288 C CA . TYR B 1 296 ? 20.457 -29.530 -1.724 1.00 14.19 ? 365 TYR B CA 1 ATOM 5289 C C . TYR B 1 296 ? 19.746 -29.686 -3.052 1.00 13.25 ? 365 TYR B C 1 ATOM 5290 O O . TYR B 1 296 ? 18.955 -30.602 -3.225 1.00 12.98 ? 365 TYR B O 1 ATOM 5291 C CB . TYR B 1 296 ? 21.777 -30.312 -1.894 1.00 14.28 ? 365 TYR B CB 1 ATOM 5292 C CG . TYR B 1 296 ? 22.665 -30.452 -0.666 1.00 14.97 ? 365 TYR B CG 1 ATOM 5293 C CD1 . TYR B 1 296 ? 23.616 -29.489 -0.334 1.00 15.20 ? 365 TYR B CD1 1 ATOM 5294 C CD2 . TYR B 1 296 ? 22.582 -31.582 0.135 1.00 14.77 ? 365 TYR B CD2 1 ATOM 5295 C CE1 . TYR B 1 296 ? 24.437 -29.652 0.810 1.00 15.47 ? 365 TYR B CE1 1 ATOM 5296 C CE2 . TYR B 1 296 ? 23.384 -31.749 1.240 1.00 14.68 ? 365 TYR B CE2 1 ATOM 5297 C CZ . TYR B 1 296 ? 24.296 -30.791 1.582 1.00 14.35 ? 365 TYR B CZ 1 ATOM 5298 O OH . TYR B 1 296 ? 25.061 -31.021 2.696 1.00 15.74 ? 365 TYR B OH 1 ATOM 5299 N N . SER B 1 297 ? 20.101 -28.839 -4.003 1.00 12.98 ? 366 SER B N 1 ATOM 5300 C CA A SER B 1 297 ? 19.585 -28.926 -5.370 0.50 13.27 ? 366 SER B CA 1 ATOM 5301 C CA B SER B 1 297 ? 19.588 -28.944 -5.368 0.50 13.10 ? 366 SER B CA 1 ATOM 5302 C C . SER B 1 297 ? 20.713 -28.891 -6.388 1.00 12.83 ? 366 SER B C 1 ATOM 5303 O O . SER B 1 297 ? 21.799 -28.413 -6.090 1.00 13.03 ? 366 SER B O 1 ATOM 5304 C CB A SER B 1 297 ? 18.632 -27.760 -5.647 0.50 13.22 ? 366 SER B CB 1 ATOM 5305 C CB B SER B 1 297 ? 18.562 -27.833 -5.643 0.50 13.04 ? 366 SER B CB 1 ATOM 5306 O OG A SER B 1 297 ? 19.343 -26.621 -6.094 0.50 14.01 ? 366 SER B OG 1 ATOM 5307 O OG B SER B 1 297 ? 18.975 -26.592 -5.103 0.50 12.73 ? 366 SER B OG 1 ATOM 5308 N N . ARG B 1 298 ? 20.445 -29.391 -7.596 1.00 12.82 ? 367 ARG B N 1 ATOM 5309 C CA . ARG B 1 298 ? 21.415 -29.318 -8.685 1.00 12.29 ? 367 ARG B CA 1 ATOM 5310 C C . ARG B 1 298 ? 20.725 -29.536 -10.015 1.00 13.12 ? 367 ARG B C 1 ATOM 5311 O O . ARG B 1 298 ? 19.684 -30.173 -10.050 1.00 12.78 ? 367 ARG B O 1 ATOM 5312 C CB . ARG B 1 298 ? 22.505 -30.381 -8.519 1.00 12.49 ? 367 ARG B CB 1 ATOM 5313 C CG . ARG B 1 298 ? 22.059 -31.835 -8.733 1.00 9.74 ? 367 ARG B CG 1 ATOM 5314 C CD . ARG B 1 298 ? 23.293 -32.758 -8.846 1.00 10.11 ? 367 ARG B CD 1 ATOM 5315 N NE . ARG B 1 298 ? 22.932 -34.152 -9.099 1.00 10.63 ? 367 ARG B NE 1 ATOM 5316 C CZ . ARG B 1 298 ? 23.797 -35.160 -9.157 1.00 10.92 ? 367 ARG B CZ 1 ATOM 5317 N NH1 . ARG B 1 298 ? 25.097 -34.958 -8.991 1.00 11.42 ? 367 ARG B NH1 1 ATOM 5318 N NH2 . ARG B 1 298 ? 23.356 -36.379 -9.406 1.00 12.67 ? 367 ARG B NH2 1 ATOM 5319 N N . THR B 1 299 ? 21.323 -29.060 -11.110 1.00 13.07 ? 368 THR B N 1 ATOM 5320 C CA . THR B 1 299 ? 20.698 -29.241 -12.424 1.00 13.66 ? 368 THR B CA 1 ATOM 5321 C C . THR B 1 299 ? 20.477 -30.732 -12.731 1.00 14.33 ? 368 THR B C 1 ATOM 5322 O O . THR B 1 299 ? 21.190 -31.603 -12.228 1.00 13.75 ? 368 THR B O 1 ATOM 5323 C CB . THR B 1 299 ? 21.505 -28.597 -13.568 1.00 13.41 ? 368 THR B CB 1 ATOM 5324 O OG1 . THR B 1 299 ? 22.805 -29.198 -13.653 1.00 12.14 ? 368 THR B OG1 1 ATOM 5325 C CG2 . THR B 1 299 ? 21.641 -27.069 -13.346 1.00 13.56 ? 368 THR B CG2 1 ATOM 5326 N N . MET B 1 300 ? 19.444 -31.010 -13.508 1.00 15.34 ? 369 MET B N 1 ATOM 5327 C CA . MET B 1 300 ? 19.204 -32.360 -14.039 1.00 16.92 ? 369 MET B CA 1 ATOM 5328 C C . MET B 1 300 ? 20.284 -32.697 -15.081 1.00 17.38 ? 369 MET B C 1 ATOM 5329 O O . MET B 1 300 ? 20.742 -33.833 -15.121 1.00 18.21 ? 369 MET B O 1 ATOM 5330 C CB . MET B 1 300 ? 17.839 -32.443 -14.724 1.00 17.49 ? 369 MET B CB 1 ATOM 5331 C CG . MET B 1 300 ? 16.729 -33.161 -14.008 1.00 20.54 ? 369 MET B CG 1 ATOM 5332 S SD . MET B 1 300 ? 16.962 -33.584 -12.288 1.00 25.76 ? 369 MET B SD 1 ATOM 5333 C CE . MET B 1 300 ? 16.806 -35.348 -12.549 1.00 23.35 ? 369 MET B CE 1 ATOM 5334 N N . SER B 1 301 ? 20.659 -31.733 -15.930 1.00 16.75 ? 370 SER B N 1 ATOM 5335 C CA . SER B 1 301 ? 21.713 -31.968 -16.928 1.00 17.12 ? 370 SER B CA 1 ATOM 5336 C C . SER B 1 301 ? 23.084 -31.804 -16.264 1.00 17.34 ? 370 SER B C 1 ATOM 5337 O O . SER B 1 301 ? 23.277 -30.922 -15.431 1.00 17.11 ? 370 SER B O 1 ATOM 5338 C CB . SER B 1 301 ? 21.537 -31.026 -18.136 1.00 16.95 ? 370 SER B CB 1 ATOM 5339 O OG . SER B 1 301 ? 22.737 -30.879 -18.861 1.00 16.55 ? 370 SER B OG 1 ATOM 5340 N N . LYS B 1 302 ? 24.034 -32.665 -16.611 1.00 17.32 ? 371 LYS B N 1 ATOM 5341 C CA . LYS B 1 302 ? 25.364 -32.586 -16.009 1.00 16.90 ? 371 LYS B CA 1 ATOM 5342 C C . LYS B 1 302 ? 26.177 -31.385 -16.504 1.00 17.25 ? 371 LYS B C 1 ATOM 5343 O O . LYS B 1 302 ? 27.075 -30.910 -15.814 1.00 17.79 ? 371 LYS B O 1 ATOM 5344 C CB . LYS B 1 302 ? 26.132 -33.875 -16.266 1.00 16.88 ? 371 LYS B CB 1 ATOM 5345 C CG . LYS B 1 302 ? 25.586 -35.070 -15.475 1.00 17.22 ? 371 LYS B CG 1 ATOM 5346 C CD . LYS B 1 302 ? 26.192 -36.414 -15.870 1.00 17.00 ? 371 LYS B CD 1 ATOM 5347 C CE . LYS B 1 302 ? 25.841 -36.825 -17.327 1.00 16.60 ? 371 LYS B CE 1 ATOM 5348 N NZ . LYS B 1 302 ? 25.724 -38.304 -17.494 1.00 15.50 ? 371 LYS B NZ 1 ATOM 5349 N N . THR B 1 303 ? 25.835 -30.891 -17.694 1.00 17.22 ? 372 THR B N 1 ATOM 5350 C CA . THR B 1 303 ? 26.585 -29.852 -18.390 1.00 16.13 ? 372 THR B CA 1 ATOM 5351 C C . THR B 1 303 ? 25.822 -28.536 -18.451 1.00 16.46 ? 372 THR B C 1 ATOM 5352 O O . THR B 1 303 ? 26.402 -27.462 -18.225 1.00 16.62 ? 372 THR B O 1 ATOM 5353 C CB . THR B 1 303 ? 26.877 -30.307 -19.833 1.00 15.92 ? 372 THR B CB 1 ATOM 5354 O OG1 . THR B 1 303 ? 27.514 -31.586 -19.815 1.00 13.28 ? 372 THR B OG1 1 ATOM 5355 C CG2 . THR B 1 303 ? 27.775 -29.323 -20.581 1.00 15.42 ? 372 THR B CG2 1 ATOM 5356 N N . LYS B 1 304 ? 24.534 -28.621 -18.793 1.00 16.24 ? 373 LYS B N 1 ATOM 5357 C CA . LYS B 1 304 ? 23.724 -27.455 -19.077 1.00 15.91 ? 373 LYS B CA 1 ATOM 5358 C C . LYS B 1 304 ? 22.854 -27.053 -17.899 1.00 15.64 ? 373 LYS B C 1 ATOM 5359 O O . LYS B 1 304 ? 22.561 -27.858 -17.007 1.00 14.83 ? 373 LYS B O 1 ATOM 5360 C CB . LYS B 1 304 ? 22.820 -27.725 -20.284 1.00 16.25 ? 373 LYS B CB 1 ATOM 5361 C CG . LYS B 1 304 ? 23.545 -28.224 -21.530 1.00 18.58 ? 373 LYS B CG 1 ATOM 5362 C CD . LYS B 1 304 ? 22.675 -28.013 -22.771 1.00 21.58 ? 373 LYS B CD 1 ATOM 5363 C CE . LYS B 1 304 ? 23.121 -28.826 -23.962 1.00 22.68 ? 373 LYS B CE 1 ATOM 5364 N NZ . LYS B 1 304 ? 22.858 -30.294 -23.800 1.00 23.81 ? 373 LYS B NZ 1 ATOM 5365 N N . ARG B 1 305 ? 22.428 -25.794 -17.943 1.00 15.64 ? 374 ARG B N 1 ATOM 5366 C CA . ARG B 1 305 ? 21.589 -25.183 -16.918 1.00 15.21 ? 374 ARG B CA 1 ATOM 5367 C C . ARG B 1 305 ? 20.139 -25.473 -17.231 1.00 15.35 ? 374 ARG B C 1 ATOM 5368 O O . ARG B 1 305 ? 19.347 -24.578 -17.493 1.00 14.29 ? 374 ARG B O 1 ATOM 5369 C CB . ARG B 1 305 ? 21.877 -23.686 -16.831 1.00 15.51 ? 374 ARG B CB 1 ATOM 5370 C CG . ARG B 1 305 ? 23.281 -23.420 -16.277 1.00 14.13 ? 374 ARG B CG 1 ATOM 5371 C CD . ARG B 1 305 ? 23.614 -21.981 -16.172 1.00 13.95 ? 374 ARG B CD 1 ATOM 5372 N NE . ARG B 1 305 ? 24.854 -21.788 -15.413 1.00 16.23 ? 374 ARG B NE 1 ATOM 5373 C CZ . ARG B 1 305 ? 25.320 -20.612 -14.985 1.00 16.26 ? 374 ARG B CZ 1 ATOM 5374 N NH1 . ARG B 1 305 ? 24.672 -19.486 -15.233 1.00 19.33 ? 374 ARG B NH1 1 ATOM 5375 N NH2 . ARG B 1 305 ? 26.442 -20.551 -14.290 1.00 16.48 ? 374 ARG B NH2 1 ATOM 5376 N N . MET B 1 306 ? 19.835 -26.773 -17.188 1.00 16.08 ? 375 MET B N 1 ATOM 5377 C CA . MET B 1 306 ? 18.542 -27.334 -17.531 1.00 16.46 ? 375 MET B CA 1 ATOM 5378 C C . MET B 1 306 ? 18.144 -28.267 -16.405 1.00 16.35 ? 375 MET B C 1 ATOM 5379 O O . MET B 1 306 ? 18.959 -29.090 -15.941 1.00 16.82 ? 375 MET B O 1 ATOM 5380 C CB . MET B 1 306 ? 18.632 -28.141 -18.838 1.00 16.83 ? 375 MET B CB 1 ATOM 5381 C CG . MET B 1 306 ? 19.026 -27.328 -20.070 1.00 18.09 ? 375 MET B CG 1 ATOM 5382 S SD . MET B 1 306 ? 17.902 -25.946 -20.347 1.00 25.30 ? 375 MET B SD 1 ATOM 5383 C CE . MET B 1 306 ? 16.540 -26.743 -21.223 1.00 22.30 ? 375 MET B CE 1 ATOM 5384 N N . GLY B 1 307 ? 16.902 -28.134 -15.974 1.00 15.34 ? 376 GLY B N 1 ATOM 5385 C CA . GLY B 1 307 ? 16.362 -28.948 -14.909 1.00 15.46 ? 376 GLY B CA 1 ATOM 5386 C C . GLY B 1 307 ? 16.873 -28.563 -13.526 1.00 14.48 ? 376 GLY B C 1 ATOM 5387 O O . GLY B 1 307 ? 17.796 -27.782 -13.382 1.00 14.10 ? 376 GLY B O 1 ATOM 5388 N N . MET B 1 308 ? 16.269 -29.147 -12.510 1.00 14.84 ? 377 MET B N 1 ATOM 5389 C CA . MET B 1 308 ? 16.748 -28.998 -11.130 1.00 15.33 ? 377 MET B CA 1 ATOM 5390 C C . MET B 1 308 ? 16.141 -30.093 -10.271 1.00 15.47 ? 377 MET B C 1 ATOM 5391 O O . MET B 1 308 ? 14.926 -30.124 -10.084 1.00 15.23 ? 377 MET B O 1 ATOM 5392 C CB . MET B 1 308 ? 16.393 -27.627 -10.573 1.00 14.94 ? 377 MET B CB 1 ATOM 5393 C CG . MET B 1 308 ? 17.119 -27.266 -9.297 1.00 17.31 ? 377 MET B CG 1 ATOM 5394 S SD . MET B 1 308 ? 18.869 -26.916 -9.500 1.00 18.60 ? 377 MET B SD 1 ATOM 5395 C CE . MET B 1 308 ? 18.842 -25.480 -10.561 1.00 17.93 ? 377 MET B CE 1 ATOM 5396 N N . GLY B 1 309 ? 16.984 -31.014 -9.796 1.00 15.80 ? 378 GLY B N 1 ATOM 5397 C CA . GLY B 1 309 ? 16.566 -32.047 -8.839 1.00 16.42 ? 378 GLY B CA 1 ATOM 5398 C C . GLY B 1 309 ? 16.854 -31.596 -7.411 1.00 16.54 ? 378 GLY B C 1 ATOM 5399 O O . GLY B 1 309 ? 17.718 -30.745 -7.193 1.00 17.79 ? 378 GLY B O 1 ATOM 5400 N N . LEU B 1 310 ? 16.105 -32.133 -6.455 1.00 16.78 ? 379 LEU B N 1 ATOM 5401 C CA . LEU B 1 310 ? 16.298 -31.875 -5.003 1.00 16.77 ? 379 LEU B CA 1 ATOM 5402 C C . LEU B 1 310 ? 16.831 -33.119 -4.344 1.00 17.35 ? 379 LEU B C 1 ATOM 5403 O O . LEU B 1 310 ? 16.311 -34.203 -4.607 1.00 16.63 ? 379 LEU B O 1 ATOM 5404 C CB . LEU B 1 310 ? 14.963 -31.559 -4.305 1.00 16.65 ? 379 LEU B CB 1 ATOM 5405 C CG . LEU B 1 310 ? 14.997 -31.385 -2.765 1.00 14.89 ? 379 LEU B CG 1 ATOM 5406 C CD1 . LEU B 1 310 ? 15.701 -30.110 -2.385 1.00 14.21 ? 379 LEU B CD1 1 ATOM 5407 C CD2 . LEU B 1 310 ? 13.626 -31.375 -2.198 1.00 12.38 ? 379 LEU B CD2 1 ATOM 5408 N N . TYR B 1 311 ? 17.809 -32.938 -3.439 1.00 18.21 ? 380 TYR B N 1 ATOM 5409 C CA . TYR B 1 311 ? 18.478 -34.032 -2.733 1.00 18.24 ? 380 TYR B CA 1 ATOM 5410 C C . TYR B 1 311 ? 18.594 -33.793 -1.190 1.00 18.96 ? 380 TYR B C 1 ATOM 5411 O O . TYR B 1 311 ? 18.613 -32.645 -0.718 1.00 18.89 ? 380 TYR B O 1 ATOM 5412 C CB . TYR B 1 311 ? 19.865 -34.207 -3.329 1.00 18.37 ? 380 TYR B CB 1 ATOM 5413 C CG . TYR B 1 311 ? 19.930 -34.630 -4.793 1.00 17.47 ? 380 TYR B CG 1 ATOM 5414 C CD1 . TYR B 1 311 ? 20.313 -35.912 -5.125 1.00 16.31 ? 380 TYR B CD1 1 ATOM 5415 C CD2 . TYR B 1 311 ? 19.655 -33.735 -5.840 1.00 18.17 ? 380 TYR B CD2 1 ATOM 5416 C CE1 . TYR B 1 311 ? 20.411 -36.323 -6.445 1.00 19.38 ? 380 TYR B CE1 1 ATOM 5417 C CE2 . TYR B 1 311 ? 19.758 -34.145 -7.217 1.00 18.00 ? 380 TYR B CE2 1 ATOM 5418 C CZ . TYR B 1 311 ? 20.125 -35.443 -7.489 1.00 18.22 ? 380 TYR B CZ 1 ATOM 5419 O OH . TYR B 1 311 ? 20.252 -35.922 -8.766 1.00 19.93 ? 380 TYR B OH 1 ATOM 5420 N N . VAL B 1 312 ? 18.698 -34.878 -0.420 1.00 19.15 ? 381 VAL B N 1 ATOM 5421 C CA . VAL B 1 312 ? 18.764 -34.797 1.042 1.00 19.50 ? 381 VAL B CA 1 ATOM 5422 C C . VAL B 1 312 ? 19.662 -35.875 1.663 1.00 20.01 ? 381 VAL B C 1 ATOM 5423 O O . VAL B 1 312 ? 19.763 -36.971 1.125 1.00 19.07 ? 381 VAL B O 1 ATOM 5424 C CB . VAL B 1 312 ? 17.337 -34.902 1.687 1.00 19.69 ? 381 VAL B CB 1 ATOM 5425 C CG1 . VAL B 1 312 ? 16.742 -36.307 1.526 1.00 16.99 ? 381 VAL B CG1 1 ATOM 5426 C CG2 . VAL B 1 312 ? 17.389 -34.513 3.148 1.00 19.22 ? 381 VAL B CG2 1 ATOM 5427 N N . LYS B 1 313 ? 20.307 -35.524 2.787 1.00 20.55 ? 382 LYS B N 1 ATOM 5428 C CA . LYS B 1 313 ? 20.985 -36.460 3.676 1.00 21.43 ? 382 LYS B CA 1 ATOM 5429 C C . LYS B 1 313 ? 20.871 -36.017 5.146 1.00 22.14 ? 382 LYS B C 1 ATOM 5430 O O . LYS B 1 313 ? 20.910 -34.824 5.480 1.00 21.42 ? 382 LYS B O 1 ATOM 5431 C CB . LYS B 1 313 ? 22.458 -36.572 3.317 1.00 22.38 ? 382 LYS B CB 1 ATOM 5432 C CG . LYS B 1 313 ? 23.143 -37.828 3.873 1.00 23.74 ? 382 LYS B CG 1 ATOM 5433 C CD . LYS B 1 313 ? 23.907 -38.587 2.774 1.00 27.49 ? 382 LYS B CD 1 ATOM 5434 C CE . LYS B 1 313 ? 24.119 -40.073 3.134 1.00 28.34 ? 382 LYS B CE 1 ATOM 5435 N NZ . LYS B 1 313 ? 24.942 -40.231 4.379 1.00 27.96 ? 382 LYS B NZ 1 ATOM 5436 N N . TYR B 1 314 ? 20.742 -36.984 6.035 1.00 22.99 ? 383 TYR B N 1 ATOM 5437 C CA . TYR B 1 314 ? 20.586 -36.667 7.446 1.00 24.22 ? 383 TYR B CA 1 ATOM 5438 C C . TYR B 1 314 ? 21.865 -36.983 8.230 1.00 23.82 ? 383 TYR B C 1 ATOM 5439 O O . TYR B 1 314 ? 22.426 -38.051 8.112 1.00 24.63 ? 383 TYR B O 1 ATOM 5440 C CB . TYR B 1 314 ? 19.365 -37.390 7.989 1.00 24.68 ? 383 TYR B CB 1 ATOM 5441 C CG . TYR B 1 314 ? 18.049 -36.851 7.439 1.00 26.12 ? 383 TYR B CG 1 ATOM 5442 C CD1 . TYR B 1 314 ? 17.351 -35.847 8.114 1.00 27.39 ? 383 TYR B CD1 1 ATOM 5443 C CD2 . TYR B 1 314 ? 17.494 -37.354 6.258 1.00 26.75 ? 383 TYR B CD2 1 ATOM 5444 C CE1 . TYR B 1 314 ? 16.129 -35.349 7.627 1.00 27.22 ? 383 TYR B CE1 1 ATOM 5445 C CE2 . TYR B 1 314 ? 16.269 -36.864 5.766 1.00 27.40 ? 383 TYR B CE2 1 ATOM 5446 C CZ . TYR B 1 314 ? 15.594 -35.867 6.468 1.00 28.32 ? 383 TYR B CZ 1 ATOM 5447 O OH . TYR B 1 314 ? 14.387 -35.365 6.006 1.00 30.98 ? 383 TYR B OH 1 ATOM 5448 N N . ASP B 1 315 ? 22.369 -36.013 8.964 1.00 24.02 ? 384 ASP B N 1 ATOM 5449 C CA . ASP B 1 315 ? 23.640 -36.171 9.696 1.00 24.59 ? 384 ASP B CA 1 ATOM 5450 C C . ASP B 1 315 ? 24.843 -36.617 8.854 1.00 24.64 ? 384 ASP B C 1 ATOM 5451 O O . ASP B 1 315 ? 24.857 -36.433 7.641 1.00 25.11 ? 384 ASP B O 1 ATOM 5452 C CB . ASP B 1 315 ? 23.439 -37.110 10.885 1.00 24.96 ? 384 ASP B CB 1 ATOM 5453 C CG . ASP B 1 315 ? 22.240 -36.738 11.692 1.00 24.69 ? 384 ASP B CG 1 ATOM 5454 O OD1 . ASP B 1 315 ? 21.445 -37.622 11.983 1.00 28.07 ? 384 ASP B OD1 1 ATOM 5455 O OD2 . ASP B 1 315 ? 22.081 -35.552 12.006 1.00 24.69 ? 384 ASP B OD2 1 ATOM 5456 N N . GLY B 1 316 ? 25.850 -37.203 9.506 1.00 24.75 ? 385 GLY B N 1 ATOM 5457 C CA . GLY B 1 316 ? 27.179 -37.356 8.930 1.00 24.61 ? 385 GLY B CA 1 ATOM 5458 C C . GLY B 1 316 ? 27.935 -36.034 8.978 1.00 24.70 ? 385 GLY B C 1 ATOM 5459 O O . GLY B 1 316 ? 27.389 -35.009 9.398 1.00 25.73 ? 385 GLY B O 1 ATOM 5460 N N . ASP B 1 317 ? 29.198 -36.057 8.565 1.00 24.48 ? 386 ASP B N 1 ATOM 5461 C CA . ASP B 1 317 ? 29.977 -34.837 8.311 1.00 23.90 ? 386 ASP B CA 1 ATOM 5462 C C . ASP B 1 317 ? 30.189 -34.716 6.781 1.00 23.37 ? 386 ASP B C 1 ATOM 5463 O O . ASP B 1 317 ? 30.810 -35.582 6.188 1.00 22.34 ? 386 ASP B O 1 ATOM 5464 C CB . ASP B 1 317 ? 31.312 -34.922 9.049 1.00 23.97 ? 386 ASP B CB 1 ATOM 5465 C CG . ASP B 1 317 ? 32.351 -33.954 8.507 1.00 24.55 ? 386 ASP B CG 1 ATOM 5466 O OD1 . ASP B 1 317 ? 31.977 -32.895 7.964 1.00 21.82 ? 386 ASP B OD1 1 ATOM 5467 O OD2 . ASP B 1 317 ? 33.556 -34.273 8.605 1.00 26.60 ? 386 ASP B OD2 1 ATOM 5468 N N . PRO B 1 318 ? 29.663 -33.643 6.137 1.00 23.09 ? 387 PRO B N 1 ATOM 5469 C CA . PRO B 1 318 ? 29.747 -33.595 4.654 1.00 22.74 ? 387 PRO B CA 1 ATOM 5470 C C . PRO B 1 318 ? 31.186 -33.507 4.104 1.00 22.49 ? 387 PRO B C 1 ATOM 5471 O O . PRO B 1 318 ? 31.426 -33.785 2.924 1.00 20.89 ? 387 PRO B O 1 ATOM 5472 C CB . PRO B 1 318 ? 28.920 -32.348 4.286 1.00 22.33 ? 387 PRO B CB 1 ATOM 5473 C CG . PRO B 1 318 ? 28.030 -32.101 5.475 1.00 22.73 ? 387 PRO B CG 1 ATOM 5474 C CD . PRO B 1 318 ? 28.831 -32.544 6.673 1.00 22.90 ? 387 PRO B CD 1 ATOM 5475 N N . TRP B 1 319 ? 32.118 -33.116 4.977 1.00 22.53 ? 388 TRP B N 1 ATOM 5476 C CA . TRP B 1 319 ? 33.537 -33.070 4.644 1.00 22.59 ? 388 TRP B CA 1 ATOM 5477 C C . TRP B 1 319 ? 34.121 -34.448 4.401 1.00 23.34 ? 388 TRP B C 1 ATOM 5478 O O . TRP B 1 319 ? 35.070 -34.605 3.618 1.00 23.36 ? 388 TRP B O 1 ATOM 5479 C CB . TRP B 1 319 ? 34.334 -32.389 5.758 1.00 22.46 ? 388 TRP B CB 1 ATOM 5480 C CG . TRP B 1 319 ? 34.238 -30.909 5.761 1.00 22.28 ? 388 TRP B CG 1 ATOM 5481 C CD1 . TRP B 1 319 ? 33.695 -30.121 4.798 1.00 21.67 ? 388 TRP B CD1 1 ATOM 5482 C CD2 . TRP B 1 319 ? 34.747 -30.024 6.757 1.00 21.88 ? 388 TRP B CD2 1 ATOM 5483 N NE1 . TRP B 1 319 ? 33.831 -28.803 5.131 1.00 20.44 ? 388 TRP B NE1 1 ATOM 5484 C CE2 . TRP B 1 319 ? 34.490 -28.712 6.320 1.00 21.01 ? 388 TRP B CE2 1 ATOM 5485 C CE3 . TRP B 1 319 ? 35.423 -30.211 7.959 1.00 21.42 ? 388 TRP B CE3 1 ATOM 5486 C CZ2 . TRP B 1 319 ? 34.853 -27.595 7.059 1.00 21.24 ? 388 TRP B CZ2 1 ATOM 5487 C CZ3 . TRP B 1 319 ? 35.780 -29.116 8.688 1.00 22.09 ? 388 TRP B CZ3 1 ATOM 5488 C CH2 . TRP B 1 319 ? 35.495 -27.822 8.242 1.00 23.07 ? 388 TRP B CH2 1 ATOM 5489 N N . THR B 1 320 ? 33.573 -35.455 5.064 1.00 24.00 ? 389 THR B N 1 ATOM 5490 C CA . THR B 1 320 ? 34.177 -36.778 4.999 1.00 24.06 ? 389 THR B CA 1 ATOM 5491 C C . THR B 1 320 ? 33.266 -37.896 4.501 1.00 24.29 ? 389 THR B C 1 ATOM 5492 O O . THR B 1 320 ? 33.762 -38.961 4.218 1.00 24.97 ? 389 THR B O 1 ATOM 5493 C CB . THR B 1 320 ? 34.752 -37.165 6.378 1.00 24.04 ? 389 THR B CB 1 ATOM 5494 O OG1 . THR B 1 320 ? 33.683 -37.368 7.300 1.00 23.48 ? 389 THR B OG1 1 ATOM 5495 C CG2 . THR B 1 320 ? 35.681 -36.086 6.892 1.00 23.45 ? 389 THR B CG2 1 ATOM 5496 N N . ASP B 1 321 ? 31.953 -37.691 4.407 1.00 24.62 ? 390 ASP B N 1 ATOM 5497 C CA . ASP B 1 321 ? 31.052 -38.782 3.999 1.00 25.01 ? 390 ASP B CA 1 ATOM 5498 C C . ASP B 1 321 ? 30.852 -38.839 2.482 1.00 24.15 ? 390 ASP B C 1 ATOM 5499 O O . ASP B 1 321 ? 30.211 -37.971 1.909 1.00 24.13 ? 390 ASP B O 1 ATOM 5500 C CB . ASP B 1 321 ? 29.687 -38.669 4.687 1.00 25.43 ? 390 ASP B CB 1 ATOM 5501 C CG . ASP B 1 321 ? 28.643 -39.575 4.037 1.00 28.07 ? 390 ASP B CG 1 ATOM 5502 O OD1 . ASP B 1 321 ? 29.055 -40.499 3.296 1.00 30.57 ? 390 ASP B OD1 1 ATOM 5503 O OD2 . ASP B 1 321 ? 27.421 -39.369 4.230 1.00 31.71 ? 390 ASP B OD2 1 ATOM 5504 N N . SER B 1 322 ? 31.360 -39.880 1.836 1.00 24.02 ? 391 SER B N 1 ATOM 5505 C CA . SER B 1 322 ? 31.291 -39.982 0.353 1.00 23.70 ? 391 SER B CA 1 ATOM 5506 C C . SER B 1 322 ? 29.966 -40.499 -0.204 1.00 23.60 ? 391 SER B C 1 ATOM 5507 O O . SER B 1 322 ? 29.769 -40.499 -1.413 1.00 24.44 ? 391 SER B O 1 ATOM 5508 C CB . SER B 1 322 ? 32.436 -40.862 -0.182 1.00 23.41 ? 391 SER B CB 1 ATOM 5509 O OG . SER B 1 322 ? 32.489 -42.119 0.473 1.00 21.27 ? 391 SER B OG 1 ATOM 5510 N N . ASP B 1 323 ? 29.073 -40.958 0.658 1.00 23.92 ? 392 ASP B N 1 ATOM 5511 C CA . ASP B 1 323 ? 27.807 -41.562 0.206 1.00 24.64 ? 392 ASP B CA 1 ATOM 5512 C C . ASP B 1 323 ? 26.942 -40.567 -0.550 1.00 24.03 ? 392 ASP B C 1 ATOM 5513 O O . ASP B 1 323 ? 26.916 -39.387 -0.215 1.00 23.66 ? 392 ASP B O 1 ATOM 5514 C CB . ASP B 1 323 ? 26.991 -42.136 1.379 1.00 24.75 ? 392 ASP B CB 1 ATOM 5515 C CG . ASP B 1 323 ? 27.597 -43.402 1.946 1.00 27.21 ? 392 ASP B CG 1 ATOM 5516 O OD1 . ASP B 1 323 ? 27.894 -44.328 1.157 1.00 28.20 ? 392 ASP B OD1 1 ATOM 5517 O OD2 . ASP B 1 323 ? 27.794 -43.470 3.190 1.00 30.06 ? 392 ASP B OD2 1 ATOM 5518 N N . ALA B 1 324 ? 26.244 -41.080 -1.561 1.00 23.55 ? 393 ALA B N 1 ATOM 5519 C CA . ALA B 1 324 ? 25.270 -40.331 -2.334 1.00 23.32 ? 393 ALA B CA 1 ATOM 5520 C C . ALA B 1 324 ? 24.263 -39.627 -1.440 1.00 22.95 ? 393 ALA B C 1 ATOM 5521 O O . ALA B 1 324 ? 23.847 -40.146 -0.402 1.00 22.48 ? 393 ALA B O 1 ATOM 5522 C CB . ALA B 1 324 ? 24.520 -41.260 -3.320 1.00 22.63 ? 393 ALA B CB 1 ATOM 5523 N N . LEU B 1 325 ? 23.892 -38.424 -1.858 1.00 23.20 ? 394 LEU B N 1 ATOM 5524 C CA . LEU B 1 325 ? 22.678 -37.767 -1.387 1.00 23.40 ? 394 LEU B CA 1 ATOM 5525 C C . LEU B 1 325 ? 21.475 -38.541 -1.929 1.00 23.16 ? 394 LEU B C 1 ATOM 5526 O O . LEU B 1 325 ? 21.570 -39.194 -2.950 1.00 24.14 ? 394 LEU B O 1 ATOM 5527 C CB . LEU B 1 325 ? 22.651 -36.317 -1.876 1.00 23.65 ? 394 LEU B CB 1 ATOM 5528 C CG . LEU B 1 325 ? 23.408 -35.179 -1.167 1.00 24.16 ? 394 LEU B CG 1 ATOM 5529 C CD1 . LEU B 1 325 ? 24.296 -35.597 0.032 1.00 22.65 ? 394 LEU B CD1 1 ATOM 5530 C CD2 . LEU B 1 325 ? 24.214 -34.374 -2.203 1.00 22.19 ? 394 LEU B CD2 1 ATOM 5531 N N . ALA B 1 326 ? 20.350 -38.481 -1.235 1.00 22.98 ? 395 ALA B N 1 ATOM 5532 C CA . ALA B 1 326 ? 19.111 -39.118 -1.680 1.00 22.90 ? 395 ALA B CA 1 ATOM 5533 C C . ALA B 1 326 ? 18.283 -38.170 -2.571 1.00 22.86 ? 395 ALA B C 1 ATOM 5534 O O . ALA B 1 326 ? 17.882 -37.095 -2.114 1.00 23.14 ? 395 ALA B O 1 ATOM 5535 C CB . ALA B 1 326 ? 18.264 -39.559 -0.462 1.00 22.36 ? 395 ALA B CB 1 ATOM 5536 N N . LEU B 1 327 ? 18.017 -38.578 -3.817 1.00 22.38 ? 396 LEU B N 1 ATOM 5537 C CA . LEU B 1 327 ? 17.092 -37.850 -4.701 1.00 22.38 ? 396 LEU B CA 1 ATOM 5538 C C . LEU B 1 327 ? 15.707 -37.858 -4.048 1.00 22.21 ? 396 LEU B C 1 ATOM 5539 O O . LEU B 1 327 ? 15.132 -38.901 -3.823 1.00 21.85 ? 396 LEU B O 1 ATOM 5540 C CB . LEU B 1 327 ? 17.036 -38.501 -6.104 1.00 22.62 ? 396 LEU B CB 1 ATOM 5541 C CG . LEU B 1 327 ? 16.225 -37.864 -7.253 1.00 23.02 ? 396 LEU B CG 1 ATOM 5542 C CD1 . LEU B 1 327 ? 16.783 -36.488 -7.641 1.00 23.74 ? 396 LEU B CD1 1 ATOM 5543 C CD2 . LEU B 1 327 ? 16.192 -38.761 -8.491 1.00 22.96 ? 396 LEU B CD2 1 ATOM 5544 N N . SER B 1 328 ? 15.196 -36.679 -3.718 1.00 22.22 ? 397 SER B N 1 ATOM 5545 C CA . SER B 1 328 ? 13.825 -36.515 -3.256 1.00 21.95 ? 397 SER B CA 1 ATOM 5546 C C . SER B 1 328 ? 12.863 -36.385 -4.450 1.00 21.09 ? 397 SER B C 1 ATOM 5547 O O . SER B 1 328 ? 11.820 -37.064 -4.518 1.00 21.08 ? 397 SER B O 1 ATOM 5548 C CB . SER B 1 328 ? 13.722 -35.292 -2.350 1.00 22.49 ? 397 SER B CB 1 ATOM 5549 O OG . SER B 1 328 ? 12.381 -35.046 -1.976 1.00 24.52 ? 397 SER B OG 1 ATOM 5550 N N . GLY B 1 329 ? 13.219 -35.537 -5.403 1.00 19.61 ? 398 GLY B N 1 ATOM 5551 C CA . GLY B 1 329 ? 12.441 -35.438 -6.616 1.00 18.69 ? 398 GLY B CA 1 ATOM 5552 C C . GLY B 1 329 ? 12.886 -34.344 -7.534 1.00 18.04 ? 398 GLY B C 1 ATOM 5553 O O . GLY B 1 329 ? 13.757 -33.554 -7.195 1.00 17.79 ? 398 GLY B O 1 ATOM 5554 N N . VAL B 1 330 ? 12.252 -34.302 -8.698 1.00 17.36 ? 399 VAL B N 1 ATOM 5555 C CA . VAL B 1 330 ? 12.608 -33.396 -9.770 1.00 16.87 ? 399 VAL B CA 1 ATOM 5556 C C . VAL B 1 330 ? 11.730 -32.156 -9.651 1.00 17.33 ? 399 VAL B C 1 ATOM 5557 O O . VAL B 1 330 ? 10.505 -32.234 -9.780 1.00 17.52 ? 399 VAL B O 1 ATOM 5558 C CB . VAL B 1 330 ? 12.420 -34.098 -11.134 1.00 17.17 ? 399 VAL B CB 1 ATOM 5559 C CG1 . VAL B 1 330 ? 12.583 -33.108 -12.334 1.00 15.24 ? 399 VAL B CG1 1 ATOM 5560 C CG2 . VAL B 1 330 ? 13.368 -35.325 -11.215 1.00 16.11 ? 399 VAL B CG2 1 ATOM 5561 N N . MET B 1 331 ? 12.365 -31.014 -9.388 1.00 17.36 ? 400 MET B N 1 ATOM 5562 C CA . MET B 1 331 ? 11.657 -29.771 -9.170 1.00 16.94 ? 400 MET B CA 1 ATOM 5563 C C . MET B 1 331 ? 11.420 -29.077 -10.500 1.00 17.06 ? 400 MET B C 1 ATOM 5564 O O . MET B 1 331 ? 10.373 -28.455 -10.704 1.00 17.03 ? 400 MET B O 1 ATOM 5565 C CB . MET B 1 331 ? 12.434 -28.856 -8.232 1.00 16.56 ? 400 MET B CB 1 ATOM 5566 C CG . MET B 1 331 ? 12.422 -29.307 -6.786 1.00 16.87 ? 400 MET B CG 1 ATOM 5567 S SD . MET B 1 331 ? 13.312 -28.168 -5.679 1.00 18.07 ? 400 MET B SD 1 ATOM 5568 C CE . MET B 1 331 ? 15.008 -28.294 -6.235 1.00 16.78 ? 400 MET B CE 1 ATOM 5569 N N . VAL B 1 332 ? 12.403 -29.160 -11.382 1.00 17.26 ? 401 VAL B N 1 ATOM 5570 C CA . VAL B 1 332 ? 12.296 -28.599 -12.724 1.00 17.64 ? 401 VAL B CA 1 ATOM 5571 C C . VAL B 1 332 ? 12.751 -29.640 -13.731 1.00 18.04 ? 401 VAL B C 1 ATOM 5572 O O . VAL B 1 332 ? 13.852 -30.181 -13.622 1.00 17.93 ? 401 VAL B O 1 ATOM 5573 C CB . VAL B 1 332 ? 13.152 -27.294 -12.873 1.00 17.86 ? 401 VAL B CB 1 ATOM 5574 C CG1 . VAL B 1 332 ? 12.932 -26.644 -14.255 1.00 16.86 ? 401 VAL B CG1 1 ATOM 5575 C CG2 . VAL B 1 332 ? 12.838 -26.292 -11.719 1.00 18.18 ? 401 VAL B CG2 1 ATOM 5576 N N . SER B 1 333 ? 11.892 -29.926 -14.698 1.00 18.84 ? 402 SER B N 1 ATOM 5577 C CA . SER B 1 333 ? 12.199 -30.884 -15.763 1.00 19.90 ? 402 SER B CA 1 ATOM 5578 C C . SER B 1 333 ? 13.335 -30.437 -16.674 1.00 20.05 ? 402 SER B C 1 ATOM 5579 O O . SER B 1 333 ? 13.565 -29.266 -16.866 1.00 19.68 ? 402 SER B O 1 ATOM 5580 C CB . SER B 1 333 ? 10.982 -31.149 -16.651 1.00 20.18 ? 402 SER B CB 1 ATOM 5581 O OG . SER B 1 333 ? 11.149 -30.509 -17.912 1.00 21.57 ? 402 SER B OG 1 ATOM 5582 N N . MET B 1 334 ? 14.006 -31.417 -17.250 1.00 21.21 ? 403 MET B N 1 ATOM 5583 C CA . MET B 1 334 ? 15.152 -31.223 -18.138 1.00 22.65 ? 403 MET B CA 1 ATOM 5584 C C . MET B 1 334 ? 14.856 -30.356 -19.363 1.00 22.48 ? 403 MET B C 1 ATOM 5585 O O . MET B 1 334 ? 15.775 -29.753 -19.927 1.00 22.33 ? 403 MET B O 1 ATOM 5586 C CB . MET B 1 334 ? 15.650 -32.599 -18.601 1.00 23.64 ? 403 MET B CB 1 ATOM 5587 C CG . MET B 1 334 ? 16.831 -32.604 -19.543 1.00 25.85 ? 403 MET B CG 1 ATOM 5588 S SD . MET B 1 334 ? 18.386 -32.879 -18.716 1.00 30.52 ? 403 MET B SD 1 ATOM 5589 C CE . MET B 1 334 ? 18.270 -34.649 -18.508 1.00 27.52 ? 403 MET B CE 1 ATOM 5590 N N . GLU B 1 335 ? 13.593 -30.283 -19.769 1.00 22.24 ? 404 GLU B N 1 ATOM 5591 C CA . GLU B 1 335 ? 13.218 -29.448 -20.911 1.00 22.88 ? 404 GLU B CA 1 ATOM 5592 C C . GLU B 1 335 ? 13.129 -27.982 -20.527 1.00 21.45 ? 404 GLU B C 1 ATOM 5593 O O . GLU B 1 335 ? 12.955 -27.137 -21.406 1.00 21.76 ? 404 GLU B O 1 ATOM 5594 C CB . GLU B 1 335 ? 11.868 -29.885 -21.513 1.00 23.86 ? 404 GLU B CB 1 ATOM 5595 C CG . GLU B 1 335 ? 11.916 -31.221 -22.247 1.00 27.17 ? 404 GLU B CG 1 ATOM 5596 C CD . GLU B 1 335 ? 11.719 -32.418 -21.328 1.00 33.61 ? 404 GLU B CD 1 ATOM 5597 O OE1 . GLU B 1 335 ? 11.984 -32.307 -20.102 1.00 37.12 ? 404 GLU B OE1 1 ATOM 5598 O OE2 . GLU B 1 335 ? 11.291 -33.485 -21.837 1.00 38.44 ? 404 GLU B OE2 1 ATOM 5599 N N . GLU B 1 336 ? 13.245 -27.687 -19.226 1.00 19.73 ? 405 GLU B N 1 ATOM 5600 C CA . GLU B 1 336 ? 13.081 -26.333 -18.707 1.00 18.45 ? 405 GLU B CA 1 ATOM 5601 C C . GLU B 1 336 ? 14.380 -25.761 -18.121 1.00 17.51 ? 405 GLU B C 1 ATOM 5602 O O . GLU B 1 336 ? 15.276 -26.508 -17.763 1.00 17.39 ? 405 GLU B O 1 ATOM 5603 C CB . GLU B 1 336 ? 11.977 -26.309 -17.676 1.00 17.96 ? 405 GLU B CB 1 ATOM 5604 C CG . GLU B 1 336 ? 10.594 -26.415 -18.302 1.00 17.43 ? 405 GLU B CG 1 ATOM 5605 C CD . GLU B 1 336 ? 9.972 -25.087 -18.690 1.00 15.64 ? 405 GLU B CD 1 ATOM 5606 O OE1 . GLU B 1 336 ? 10.466 -24.025 -18.289 1.00 19.29 ? 405 GLU B OE1 1 ATOM 5607 O OE2 . GLU B 1 336 ? 8.953 -25.103 -19.397 1.00 18.46 ? 405 GLU B OE2 1 ATOM 5608 N N . PRO B 1 337 ? 14.516 -24.431 -18.113 1.00 16.24 ? 406 PRO B N 1 ATOM 5609 C CA . PRO B 1 337 ? 15.757 -23.842 -17.621 1.00 15.83 ? 406 PRO B CA 1 ATOM 5610 C C . PRO B 1 337 ? 15.915 -23.938 -16.093 1.00 14.91 ? 406 PRO B C 1 ATOM 5611 O O . PRO B 1 337 ? 14.964 -23.726 -15.342 1.00 13.11 ? 406 PRO B O 1 ATOM 5612 C CB . PRO B 1 337 ? 15.681 -22.383 -18.083 1.00 15.85 ? 406 PRO B CB 1 ATOM 5613 C CG . PRO B 1 337 ? 14.277 -22.141 -18.447 1.00 17.00 ? 406 PRO B CG 1 ATOM 5614 C CD . PRO B 1 337 ? 13.673 -23.454 -18.817 1.00 16.55 ? 406 PRO B CD 1 ATOM 5615 N N . GLY B 1 338 ? 17.125 -24.275 -15.675 1.00 14.16 ? 407 GLY B N 1 ATOM 5616 C CA . GLY B 1 338 ? 17.494 -24.337 -14.276 1.00 13.62 ? 407 GLY B CA 1 ATOM 5617 C C . GLY B 1 338 ? 18.815 -23.661 -14.053 1.00 13.45 ? 407 GLY B C 1 ATOM 5618 O O . GLY B 1 338 ? 19.835 -24.214 -14.401 1.00 13.01 ? 407 GLY B O 1 ATOM 5619 N N . TRP B 1 339 ? 18.789 -22.458 -13.470 1.00 13.63 ? 408 TRP B N 1 ATOM 5620 C CA . TRP B 1 339 ? 20.008 -21.690 -13.254 1.00 13.73 ? 408 TRP B CA 1 ATOM 5621 C C . TRP B 1 339 ? 20.287 -21.641 -11.742 1.00 14.08 ? 408 TRP B C 1 ATOM 5622 O O . TRP B 1 339 ? 20.282 -22.673 -11.087 1.00 14.78 ? 408 TRP B O 1 ATOM 5623 C CB . TRP B 1 339 ? 19.902 -20.313 -13.909 1.00 13.26 ? 408 TRP B CB 1 ATOM 5624 C CG . TRP B 1 339 ? 19.937 -20.392 -15.393 1.00 11.90 ? 408 TRP B CG 1 ATOM 5625 C CD1 . TRP B 1 339 ? 19.246 -21.275 -16.192 1.00 12.57 ? 408 TRP B CD1 1 ATOM 5626 C CD2 . TRP B 1 339 ? 20.711 -19.577 -16.280 1.00 10.75 ? 408 TRP B CD2 1 ATOM 5627 N NE1 . TRP B 1 339 ? 19.558 -21.068 -17.522 1.00 12.19 ? 408 TRP B NE1 1 ATOM 5628 C CE2 . TRP B 1 339 ? 20.448 -20.026 -17.606 1.00 13.04 ? 408 TRP B CE2 1 ATOM 5629 C CE3 . TRP B 1 339 ? 21.599 -18.521 -16.094 1.00 10.75 ? 408 TRP B CE3 1 ATOM 5630 C CZ2 . TRP B 1 339 ? 21.057 -19.452 -18.729 1.00 12.04 ? 408 TRP B CZ2 1 ATOM 5631 C CZ3 . TRP B 1 339 ? 22.218 -17.953 -17.222 1.00 12.84 ? 408 TRP B CZ3 1 ATOM 5632 C CH2 . TRP B 1 339 ? 21.934 -18.418 -18.519 1.00 12.05 ? 408 TRP B CH2 1 ATOM 5633 N N . TYR B 1 340 ? 20.521 -20.470 -11.187 1.00 14.49 ? 409 TYR B N 1 ATOM 5634 C CA . TYR B 1 340 ? 20.938 -20.380 -9.797 1.00 14.77 ? 409 TYR B CA 1 ATOM 5635 C C . TYR B 1 340 ? 19.881 -20.951 -8.896 1.00 14.25 ? 409 TYR B C 1 ATOM 5636 O O . TYR B 1 340 ? 18.716 -20.943 -9.253 1.00 14.25 ? 409 TYR B O 1 ATOM 5637 C CB . TYR B 1 340 ? 21.185 -18.918 -9.415 1.00 15.02 ? 409 TYR B CB 1 ATOM 5638 C CG . TYR B 1 340 ? 22.529 -18.368 -9.818 1.00 15.01 ? 409 TYR B CG 1 ATOM 5639 C CD1 . TYR B 1 340 ? 23.313 -18.997 -10.804 1.00 15.96 ? 409 TYR B CD1 1 ATOM 5640 C CD2 . TYR B 1 340 ? 23.008 -17.207 -9.235 1.00 14.27 ? 409 TYR B CD2 1 ATOM 5641 C CE1 . TYR B 1 340 ? 24.550 -18.484 -11.176 1.00 16.95 ? 409 TYR B CE1 1 ATOM 5642 C CE2 . TYR B 1 340 ? 24.248 -16.686 -9.591 1.00 16.95 ? 409 TYR B CE2 1 ATOM 5643 C CZ . TYR B 1 340 ? 25.015 -17.316 -10.573 1.00 16.37 ? 409 TYR B CZ 1 ATOM 5644 O OH . TYR B 1 340 ? 26.241 -16.801 -10.920 1.00 14.92 ? 409 TYR B OH 1 ATOM 5645 N N . SER B 1 341 ? 20.287 -21.434 -7.730 1.00 13.79 ? 410 SER B N 1 ATOM 5646 C CA . SER B 1 341 ? 19.336 -21.818 -6.690 1.00 13.84 ? 410 SER B CA 1 ATOM 5647 C C . SER B 1 341 ? 19.842 -21.414 -5.319 1.00 13.62 ? 410 SER B C 1 ATOM 5648 O O . SER B 1 341 ? 21.025 -21.124 -5.143 1.00 12.94 ? 410 SER B O 1 ATOM 5649 C CB . SER B 1 341 ? 19.015 -23.329 -6.743 1.00 14.51 ? 410 SER B CB 1 ATOM 5650 O OG . SER B 1 341 ? 20.177 -24.154 -6.694 1.00 15.25 ? 410 SER B OG 1 ATOM 5651 N N . PHE B 1 342 ? 18.939 -21.370 -4.351 1.00 13.84 ? 411 PHE B N 1 ATOM 5652 C CA . PHE B 1 342 ? 19.265 -20.830 -3.040 1.00 14.74 ? 411 PHE B CA 1 ATOM 5653 C C . PHE B 1 342 ? 18.355 -21.380 -1.966 1.00 15.48 ? 411 PHE B C 1 ATOM 5654 O O . PHE B 1 342 ? 17.264 -21.872 -2.257 1.00 15.42 ? 411 PHE B O 1 ATOM 5655 C CB . PHE B 1 342 ? 19.126 -19.297 -3.081 1.00 15.30 ? 411 PHE B CB 1 ATOM 5656 C CG . PHE B 1 342 ? 17.756 -18.832 -3.526 1.00 14.18 ? 411 PHE B CG 1 ATOM 5657 C CD1 . PHE B 1 342 ? 17.487 -18.611 -4.892 1.00 11.69 ? 411 PHE B CD1 1 ATOM 5658 C CD2 . PHE B 1 342 ? 16.748 -18.627 -2.591 1.00 10.71 ? 411 PHE B CD2 1 ATOM 5659 C CE1 . PHE B 1 342 ? 16.231 -18.215 -5.316 1.00 10.16 ? 411 PHE B CE1 1 ATOM 5660 C CE2 . PHE B 1 342 ? 15.477 -18.216 -2.996 1.00 11.93 ? 411 PHE B CE2 1 ATOM 5661 C CZ . PHE B 1 342 ? 15.213 -18.026 -4.400 1.00 12.92 ? 411 PHE B CZ 1 ATOM 5662 N N . GLY B 1 343 ? 18.788 -21.246 -0.713 1.00 16.65 ? 412 GLY B N 1 ATOM 5663 C CA . GLY B 1 343 ? 17.978 -21.628 0.436 1.00 16.71 ? 412 GLY B CA 1 ATOM 5664 C C . GLY B 1 343 ? 17.437 -20.431 1.181 1.00 17.69 ? 412 GLY B C 1 ATOM 5665 O O . GLY B 1 343 ? 17.971 -19.324 1.080 1.00 18.35 ? 412 GLY B O 1 ATOM 5666 N N . PHE B 1 344 ? 16.334 -20.649 1.891 1.00 18.08 ? 413 PHE B N 1 ATOM 5667 C CA . PHE B 1 344 ? 15.843 -19.707 2.871 1.00 18.31 ? 413 PHE B CA 1 ATOM 5668 C C . PHE B 1 344 ? 14.884 -20.390 3.803 1.00 18.70 ? 413 PHE B C 1 ATOM 5669 O O . PHE B 1 344 ? 14.488 -21.529 3.569 1.00 18.93 ? 413 PHE B O 1 ATOM 5670 C CB . PHE B 1 344 ? 15.171 -18.503 2.234 1.00 18.48 ? 413 PHE B CB 1 ATOM 5671 C CG . PHE B 1 344 ? 13.932 -18.820 1.495 1.00 17.72 ? 413 PHE B CG 1 ATOM 5672 C CD1 . PHE B 1 344 ? 12.700 -18.550 2.057 1.00 17.17 ? 413 PHE B CD1 1 ATOM 5673 C CD2 . PHE B 1 344 ? 14.000 -19.368 0.195 1.00 17.96 ? 413 PHE B CD2 1 ATOM 5674 C CE1 . PHE B 1 344 ? 11.532 -18.842 1.356 1.00 18.59 ? 413 PHE B CE1 1 ATOM 5675 C CE2 . PHE B 1 344 ? 12.855 -19.669 -0.510 1.00 17.11 ? 413 PHE B CE2 1 ATOM 5676 C CZ . PHE B 1 344 ? 11.613 -19.399 0.056 1.00 18.88 ? 413 PHE B CZ 1 ATOM 5677 N N . GLU B 1 345 ? 14.545 -19.695 4.884 1.00 19.03 ? 414 GLU B N 1 ATOM 5678 C CA . GLU B 1 345 ? 13.648 -20.224 5.902 1.00 18.83 ? 414 GLU B CA 1 ATOM 5679 C C . GLU B 1 345 ? 12.526 -19.258 6.226 1.00 18.20 ? 414 GLU B C 1 ATOM 5680 O O . GLU B 1 345 ? 12.778 -18.104 6.445 1.00 17.00 ? 414 GLU B O 1 ATOM 5681 C CB . GLU B 1 345 ? 14.446 -20.532 7.175 1.00 18.93 ? 414 GLU B CB 1 ATOM 5682 C CG . GLU B 1 345 ? 15.385 -21.677 6.979 1.00 19.52 ? 414 GLU B CG 1 ATOM 5683 C CD . GLU B 1 345 ? 16.117 -22.063 8.256 1.00 22.01 ? 414 GLU B CD 1 ATOM 5684 O OE1 . GLU B 1 345 ? 17.350 -22.245 8.172 1.00 22.90 ? 414 GLU B OE1 1 ATOM 5685 O OE2 . GLU B 1 345 ? 15.468 -22.188 9.331 1.00 18.93 ? 414 GLU B OE2 1 ATOM 5686 N N . ILE B 1 346 ? 11.290 -19.749 6.272 1.00 18.90 ? 415 ILE B N 1 ATOM 5687 C CA . ILE B 1 346 ? 10.148 -18.950 6.738 1.00 19.07 ? 415 ILE B CA 1 ATOM 5688 C C . ILE B 1 346 ? 9.906 -19.194 8.240 1.00 19.95 ? 415 ILE B C 1 ATOM 5689 O O . ILE B 1 346 ? 10.050 -20.313 8.721 1.00 20.12 ? 415 ILE B O 1 ATOM 5690 C CB . ILE B 1 346 ? 8.889 -19.308 5.995 1.00 19.26 ? 415 ILE B CB 1 ATOM 5691 C CG1 . ILE B 1 346 ? 9.141 -19.294 4.463 1.00 18.73 ? 415 ILE B CG1 1 ATOM 5692 C CG2 . ILE B 1 346 ? 7.752 -18.347 6.392 1.00 18.69 ? 415 ILE B CG2 1 ATOM 5693 C CD1 . ILE B 1 346 ? 8.167 -20.110 3.697 1.00 16.38 ? 415 ILE B CD1 1 ATOM 5694 N N . LYS B 1 347 ? 9.540 -18.138 8.964 1.00 20.16 ? 416 LYS B N 1 ATOM 5695 C CA . LYS B 1 347 ? 9.219 -18.240 10.379 1.00 20.78 ? 416 LYS B CA 1 ATOM 5696 C C . LYS B 1 347 ? 7.708 -18.453 10.594 1.00 20.67 ? 416 LYS B C 1 ATOM 5697 O O . LYS B 1 347 ? 6.886 -17.611 10.258 1.00 21.25 ? 416 LYS B O 1 ATOM 5698 C CB . LYS B 1 347 ? 9.760 -17.011 11.139 1.00 20.91 ? 416 LYS B CB 1 ATOM 5699 C CG . LYS B 1 347 ? 11.290 -17.024 11.257 0.50 21.28 ? 416 LYS B CG 1 ATOM 5700 C CD . LYS B 1 347 ? 11.861 -15.775 11.916 0.50 22.71 ? 416 LYS B CD 1 ATOM 5701 C CE . LYS B 1 347 ? 11.993 -15.915 13.439 0.50 23.07 ? 416 LYS B CE 1 ATOM 5702 N NZ . LYS B 1 347 ? 10.763 -15.470 14.172 0.50 22.39 ? 416 LYS B NZ 1 ATOM 5703 N N . ASP B 1 348 ? 7.354 -19.628 11.100 1.00 20.49 ? 417 ASP B N 1 ATOM 5704 C CA . ASP B 1 348 ? 6.010 -19.919 11.563 1.00 20.10 ? 417 ASP B CA 1 ATOM 5705 C C . ASP B 1 348 ? 5.997 -19.557 13.071 1.00 20.87 ? 417 ASP B C 1 ATOM 5706 O O . ASP B 1 348 ? 6.964 -19.009 13.615 1.00 20.29 ? 417 ASP B O 1 ATOM 5707 C CB . ASP B 1 348 ? 5.698 -21.405 11.284 1.00 19.99 ? 417 ASP B CB 1 ATOM 5708 C CG . ASP B 1 348 ? 4.256 -21.832 11.640 1.00 18.38 ? 417 ASP B CG 1 ATOM 5709 O OD1 . ASP B 1 348 ? 3.357 -20.982 11.810 1.00 16.55 ? 417 ASP B OD1 1 ATOM 5710 O OD2 . ASP B 1 348 ? 4.041 -23.051 11.768 1.00 15.37 ? 417 ASP B OD2 1 ATOM 5711 N N . LYS B 1 349 ? 4.896 -19.852 13.740 1.00 22.17 ? 418 LYS B N 1 ATOM 5712 C CA . LYS B 1 349 ? 4.644 -19.330 15.084 1.00 22.95 ? 418 LYS B CA 1 ATOM 5713 C C . LYS B 1 349 ? 5.680 -19.826 16.080 1.00 22.11 ? 418 LYS B C 1 ATOM 5714 O O . LYS B 1 349 ? 6.224 -19.043 16.843 1.00 20.80 ? 418 LYS B O 1 ATOM 5715 C CB . LYS B 1 349 ? 3.230 -19.705 15.542 1.00 23.45 ? 418 LYS B CB 1 ATOM 5716 C CG . LYS B 1 349 ? 2.127 -18.812 14.969 1.00 26.07 ? 418 LYS B CG 1 ATOM 5717 C CD . LYS B 1 349 ? 0.753 -19.056 15.674 1.00 30.34 ? 418 LYS B CD 1 ATOM 5718 C CE . LYS B 1 349 ? 0.686 -18.474 17.095 1.00 30.59 ? 418 LYS B CE 1 ATOM 5719 N NZ . LYS B 1 349 ? 0.140 -17.082 17.082 1.00 31.42 ? 418 LYS B NZ 1 ATOM 5720 N N . LYS B 1 350 ? 5.968 -21.124 16.037 1.00 22.20 ? 419 LYS B N 1 ATOM 5721 C CA . LYS B 1 350 ? 6.920 -21.745 16.967 1.00 22.05 ? 419 LYS B CA 1 ATOM 5722 C C . LYS B 1 350 ? 8.102 -22.507 16.310 1.00 21.89 ? 419 LYS B C 1 ATOM 5723 O O . LYS B 1 350 ? 8.952 -23.044 17.018 1.00 21.56 ? 419 LYS B O 1 ATOM 5724 C CB . LYS B 1 350 ? 6.151 -22.663 17.920 1.00 22.29 ? 419 LYS B CB 1 ATOM 5725 C CG . LYS B 1 350 ? 5.312 -21.901 18.965 1.00 22.69 ? 419 LYS B CG 1 ATOM 5726 C CD . LYS B 1 350 ? 4.628 -22.858 19.956 0.50 22.56 ? 419 LYS B CD 1 ATOM 5727 C CE . LYS B 1 350 ? 3.243 -23.269 19.497 0.50 22.10 ? 419 LYS B CE 1 ATOM 5728 N NZ . LYS B 1 350 ? 2.894 -24.644 19.945 0.50 21.20 ? 419 LYS B NZ 1 ATOM 5729 N N . CYS B 1 351 ? 8.166 -22.541 14.977 1.00 21.24 ? 420 CYS B N 1 ATOM 5730 C CA . CYS B 1 351 ? 9.208 -23.288 14.266 1.00 21.04 ? 420 CYS B CA 1 ATOM 5731 C C . CYS B 1 351 ? 9.525 -22.659 12.902 1.00 20.96 ? 420 CYS B C 1 ATOM 5732 O O . CYS B 1 351 ? 8.705 -21.907 12.379 1.00 21.03 ? 420 CYS B O 1 ATOM 5733 C CB . CYS B 1 351 ? 8.771 -24.743 14.093 1.00 20.99 ? 420 CYS B CB 1 ATOM 5734 S SG . CYS B 1 351 ? 7.228 -24.940 13.198 1.00 21.25 ? 420 CYS B SG 1 ATOM 5735 N N . ASP B 1 352 ? 10.699 -22.986 12.340 1.00 20.72 ? 421 ASP B N 1 ATOM 5736 C CA . ASP B 1 352 ? 11.176 -22.440 11.045 1.00 20.17 ? 421 ASP B CA 1 ATOM 5737 C C . ASP B 1 352 ? 10.914 -23.420 9.886 1.00 19.32 ? 421 ASP B C 1 ATOM 5738 O O . ASP B 1 352 ? 11.181 -24.610 10.030 1.00 19.46 ? 421 ASP B O 1 ATOM 5739 C CB . ASP B 1 352 ? 12.686 -22.130 11.112 1.00 20.44 ? 421 ASP B CB 1 ATOM 5740 C CG . ASP B 1 352 ? 13.072 -21.227 12.305 1.00 21.19 ? 421 ASP B CG 1 ATOM 5741 O OD1 . ASP B 1 352 ? 12.214 -20.495 12.819 1.00 20.24 ? 421 ASP B OD1 1 ATOM 5742 O OD2 . ASP B 1 352 ? 14.249 -21.253 12.725 1.00 22.38 ? 421 ASP B OD2 1 ATOM 5743 N N . VAL B 1 353 ? 10.419 -22.929 8.744 1.00 18.31 ? 422 VAL B N 1 ATOM 5744 C CA . VAL B 1 353 ? 10.156 -23.794 7.578 1.00 18.19 ? 422 VAL B CA 1 ATOM 5745 C C . VAL B 1 353 ? 11.202 -23.675 6.473 1.00 18.30 ? 422 VAL B C 1 ATOM 5746 O O . VAL B 1 353 ? 11.242 -22.676 5.774 1.00 17.98 ? 422 VAL B O 1 ATOM 5747 C CB . VAL B 1 353 ? 8.773 -23.519 6.931 1.00 18.75 ? 422 VAL B CB 1 ATOM 5748 C CG1 . VAL B 1 353 ? 8.603 -24.352 5.676 1.00 17.60 ? 422 VAL B CG1 1 ATOM 5749 C CG2 . VAL B 1 353 ? 7.635 -23.802 7.938 1.00 17.85 ? 422 VAL B CG2 1 ATOM 5750 N N . PRO B 1 354 ? 12.018 -24.727 6.275 1.00 18.32 ? 423 PRO B N 1 ATOM 5751 C CA . PRO B 1 354 ? 13.065 -24.694 5.262 1.00 18.00 ? 423 PRO B CA 1 ATOM 5752 C C . PRO B 1 354 ? 12.536 -24.746 3.818 1.00 17.67 ? 423 PRO B C 1 ATOM 5753 O O . PRO B 1 354 ? 11.582 -25.475 3.537 1.00 16.87 ? 423 PRO B O 1 ATOM 5754 C CB . PRO B 1 354 ? 13.929 -25.933 5.571 1.00 18.20 ? 423 PRO B CB 1 ATOM 5755 C CG . PRO B 1 354 ? 13.186 -26.757 6.548 1.00 18.60 ? 423 PRO B CG 1 ATOM 5756 C CD . PRO B 1 354 ? 12.003 -25.979 7.052 1.00 18.66 ? 423 PRO B CD 1 ATOM 5757 N N . CYS B 1 355 ? 13.178 -23.979 2.925 1.00 17.02 ? 424 CYS B N 1 ATOM 5758 C CA . CYS B 1 355 ? 12.755 -23.856 1.538 1.00 16.83 ? 424 CYS B CA 1 ATOM 5759 C C . CYS B 1 355 ? 13.924 -23.679 0.564 1.00 16.39 ? 424 CYS B C 1 ATOM 5760 O O . CYS B 1 355 ? 14.971 -23.174 0.934 1.00 16.21 ? 424 CYS B O 1 ATOM 5761 C CB . CYS B 1 355 ? 11.876 -22.624 1.384 1.00 17.84 ? 424 CYS B CB 1 ATOM 5762 S SG . CYS B 1 355 ? 10.339 -22.579 2.305 1.00 19.60 ? 424 CYS B SG 1 ATOM 5763 N N . ILE B 1 356 ? 13.706 -24.030 -0.700 1.00 15.91 ? 425 ILE B N 1 ATOM 5764 C CA . ILE B 1 356 ? 14.712 -23.850 -1.766 1.00 15.64 ? 425 ILE B CA 1 ATOM 5765 C C . ILE B 1 356 ? 14.081 -23.101 -2.914 1.00 14.88 ? 425 ILE B C 1 ATOM 5766 O O . ILE B 1 356 ? 12.997 -23.465 -3.345 1.00 15.16 ? 425 ILE B O 1 ATOM 5767 C CB . ILE B 1 356 ? 15.241 -25.210 -2.289 1.00 16.14 ? 425 ILE B CB 1 ATOM 5768 C CG1 . ILE B 1 356 ? 16.138 -25.868 -1.224 1.00 17.25 ? 425 ILE B CG1 1 ATOM 5769 C CG2 . ILE B 1 356 ? 15.981 -25.062 -3.639 1.00 14.49 ? 425 ILE B CG2 1 ATOM 5770 C CD1 . ILE B 1 356 ? 17.584 -25.566 -1.341 1.00 18.76 ? 425 ILE B CD1 1 ATOM 5771 N N . GLY B 1 357 ? 14.745 -22.046 -3.387 1.00 13.71 ? 426 GLY B N 1 ATOM 5772 C CA . GLY B 1 357 ? 14.250 -21.270 -4.534 1.00 13.38 ? 426 GLY B CA 1 ATOM 5773 C C . GLY B 1 357 ? 15.065 -21.578 -5.778 1.00 13.02 ? 426 GLY B C 1 ATOM 5774 O O . GLY B 1 357 ? 16.210 -21.996 -5.654 1.00 12.52 ? 426 GLY B O 1 ATOM 5775 N N . ILE B 1 358 ? 14.488 -21.359 -6.969 1.00 12.73 ? 427 ILE B N 1 ATOM 5776 C CA . ILE B 1 358 ? 15.148 -21.730 -8.229 1.00 12.73 ? 427 ILE B CA 1 ATOM 5777 C C . ILE B 1 358 ? 14.991 -20.672 -9.332 1.00 12.19 ? 427 ILE B C 1 ATOM 5778 O O . ILE B 1 358 ? 13.886 -20.369 -9.781 1.00 11.15 ? 427 ILE B O 1 ATOM 5779 C CB . ILE B 1 358 ? 14.582 -23.017 -8.802 1.00 13.04 ? 427 ILE B CB 1 ATOM 5780 C CG1 . ILE B 1 358 ? 14.629 -24.161 -7.809 1.00 14.18 ? 427 ILE B CG1 1 ATOM 5781 C CG2 . ILE B 1 358 ? 15.355 -23.414 -10.052 1.00 13.73 ? 427 ILE B CG2 1 ATOM 5782 C CD1 . ILE B 1 358 ? 13.586 -25.245 -8.123 1.00 13.90 ? 427 ILE B CD1 1 ATOM 5783 N N . GLU B 1 359 ? 16.117 -20.149 -9.793 1.00 12.39 ? 428 GLU B N 1 ATOM 5784 C CA . GLU B 1 359 ? 16.131 -19.159 -10.859 1.00 12.49 ? 428 GLU B CA 1 ATOM 5785 C C . GLU B 1 359 ? 15.947 -19.914 -12.162 1.00 12.47 ? 428 GLU B C 1 ATOM 5786 O O . GLU B 1 359 ? 16.726 -20.807 -12.455 1.00 12.77 ? 428 GLU B O 1 ATOM 5787 C CB . GLU B 1 359 ? 17.459 -18.413 -10.865 1.00 11.73 ? 428 GLU B CB 1 ATOM 5788 C CG . GLU B 1 359 ? 17.553 -17.264 -11.831 1.00 13.73 ? 428 GLU B CG 1 ATOM 5789 C CD . GLU B 1 359 ? 18.966 -16.711 -12.017 1.00 12.09 ? 428 GLU B CD 1 ATOM 5790 O OE1 . GLU B 1 359 ? 19.932 -17.493 -12.013 1.00 10.07 ? 428 GLU B OE1 1 ATOM 5791 O OE2 . GLU B 1 359 ? 19.103 -15.487 -12.211 1.00 14.85 ? 428 GLU B OE2 1 ATOM 5792 N N . MET B 1 360 ? 14.933 -19.542 -12.931 1.00 12.53 ? 429 MET B N 1 ATOM 5793 C CA . MET B 1 360 ? 14.667 -20.133 -14.261 1.00 12.75 ? 429 MET B CA 1 ATOM 5794 C C . MET B 1 360 ? 14.864 -19.060 -15.372 1.00 12.77 ? 429 MET B C 1 ATOM 5795 O O . MET B 1 360 ? 13.978 -18.245 -15.654 1.00 12.16 ? 429 MET B O 1 ATOM 5796 C CB . MET B 1 360 ? 13.250 -20.712 -14.285 1.00 12.61 ? 429 MET B CB 1 ATOM 5797 C CG . MET B 1 360 ? 13.037 -21.859 -13.280 1.00 15.58 ? 429 MET B CG 1 ATOM 5798 S SD . MET B 1 360 ? 11.349 -22.493 -13.053 1.00 20.85 ? 429 MET B SD 1 ATOM 5799 C CE . MET B 1 360 ? 11.169 -23.418 -14.559 1.00 15.42 ? 429 MET B CE 1 ATOM 5800 N N . VAL B 1 361 ? 16.033 -19.034 -15.983 1.00 12.74 ? 430 VAL B N 1 ATOM 5801 C CA . VAL B 1 361 ? 16.369 -17.911 -16.845 1.00 13.20 ? 430 VAL B CA 1 ATOM 5802 C C . VAL B 1 361 ? 15.776 -18.136 -18.254 1.00 14.16 ? 430 VAL B C 1 ATOM 5803 O O . VAL B 1 361 ? 15.867 -19.242 -18.790 1.00 13.95 ? 430 VAL B O 1 ATOM 5804 C CB . VAL B 1 361 ? 17.910 -17.684 -16.919 1.00 12.86 ? 430 VAL B CB 1 ATOM 5805 C CG1 . VAL B 1 361 ? 18.264 -16.822 -18.099 1.00 14.14 ? 430 VAL B CG1 1 ATOM 5806 C CG2 . VAL B 1 361 ? 18.457 -17.081 -15.649 1.00 11.06 ? 430 VAL B CG2 1 ATOM 5807 N N . HIS B 1 362 ? 15.139 -17.095 -18.800 1.00 14.81 ? 431 HIS B N 1 ATOM 5808 C CA . HIS B 1 362 ? 14.724 -17.051 -20.232 1.00 16.18 ? 431 HIS B CA 1 ATOM 5809 C C . HIS B 1 362 ? 15.933 -16.581 -21.041 1.00 16.98 ? 431 HIS B C 1 ATOM 5810 O O . HIS B 1 362 ? 16.246 -15.382 -21.108 1.00 17.41 ? 431 HIS B O 1 ATOM 5811 C CB . HIS B 1 362 ? 13.500 -16.133 -20.429 1.00 15.66 ? 431 HIS B CB 1 ATOM 5812 C CG . HIS B 1 362 ? 12.465 -16.294 -19.353 1.00 15.08 ? 431 HIS B CG 1 ATOM 5813 N ND1 . HIS B 1 362 ? 11.537 -17.314 -19.364 1.00 15.58 ? 431 HIS B ND1 1 ATOM 5814 C CD2 . HIS B 1 362 ? 12.267 -15.620 -18.194 1.00 15.84 ? 431 HIS B CD2 1 ATOM 5815 C CE1 . HIS B 1 362 ? 10.785 -17.234 -18.274 1.00 16.63 ? 431 HIS B CE1 1 ATOM 5816 N NE2 . HIS B 1 362 ? 11.209 -16.219 -17.545 1.00 14.87 ? 431 HIS B NE2 1 ATOM 5817 N N . ASP B 1 363 ? 16.658 -17.535 -21.601 1.00 17.54 ? 432 ASP B N 1 ATOM 5818 C CA . ASP B 1 363 ? 17.851 -17.201 -22.361 1.00 18.55 ? 432 ASP B CA 1 ATOM 5819 C C . ASP B 1 363 ? 17.646 -17.404 -23.868 1.00 19.78 ? 432 ASP B C 1 ATOM 5820 O O . ASP B 1 363 ? 17.400 -18.532 -24.320 1.00 19.81 ? 432 ASP B O 1 ATOM 5821 C CB . ASP B 1 363 ? 18.993 -18.088 -21.904 1.00 18.50 ? 432 ASP B CB 1 ATOM 5822 C CG . ASP B 1 363 ? 20.330 -17.656 -22.464 1.00 18.25 ? 432 ASP B CG 1 ATOM 5823 O OD1 . ASP B 1 363 ? 20.423 -16.529 -23.001 1.00 18.56 ? 432 ASP B OD1 1 ATOM 5824 O OD2 . ASP B 1 363 ? 21.296 -18.440 -22.337 1.00 18.04 ? 432 ASP B OD2 1 ATOM 5825 N N . GLY B 1 364 ? 17.765 -16.329 -24.643 1.00 20.62 ? 433 GLY B N 1 ATOM 5826 C CA . GLY B 1 364 ? 17.765 -16.447 -26.104 1.00 21.71 ? 433 GLY B CA 1 ATOM 5827 C C . GLY B 1 364 ? 19.073 -15.944 -26.691 1.00 22.55 ? 433 GLY B C 1 ATOM 5828 O O . GLY B 1 364 ? 19.156 -15.666 -27.891 1.00 22.52 ? 433 GLY B O 1 ATOM 5829 N N . GLY B 1 365 ? 20.104 -15.838 -25.850 1.00 23.21 ? 434 GLY B N 1 ATOM 5830 C CA . GLY B 1 365 ? 21.365 -15.211 -26.259 1.00 24.00 ? 434 GLY B CA 1 ATOM 5831 C C . GLY B 1 365 ? 21.341 -13.717 -26.009 1.00 24.73 ? 434 GLY B C 1 ATOM 5832 O O . GLY B 1 365 ? 20.342 -13.175 -25.549 1.00 25.57 ? 434 GLY B O 1 ATOM 5833 N N . LYS B 1 366 ? 22.448 -13.049 -26.296 1.00 25.70 ? 435 LYS B N 1 ATOM 5834 C CA . LYS B 1 366 ? 22.590 -11.599 -26.021 1.00 26.22 ? 435 LYS B CA 1 ATOM 5835 C C . LYS B 1 366 ? 21.820 -10.646 -26.944 1.00 26.00 ? 435 LYS B C 1 ATOM 5836 O O . LYS B 1 366 ? 21.814 -9.442 -26.704 1.00 26.07 ? 435 LYS B O 1 ATOM 5837 C CB . LYS B 1 366 ? 24.065 -11.206 -26.083 1.00 26.41 ? 435 LYS B CB 1 ATOM 5838 C CG . LYS B 1 366 ? 24.705 -11.348 -27.460 1.00 28.18 ? 435 LYS B CG 1 ATOM 5839 C CD . LYS B 1 366 ? 26.219 -11.104 -27.403 1.00 30.49 ? 435 LYS B CD 1 ATOM 5840 C CE . LYS B 1 366 ? 26.735 -10.489 -28.731 1.00 32.43 ? 435 LYS B CE 1 ATOM 5841 N NZ . LYS B 1 366 ? 26.353 -11.285 -29.967 1.00 32.26 ? 435 LYS B NZ 1 ATOM 5842 N N . GLU B 1 367 ? 21.198 -11.165 -27.998 1.00 25.94 ? 436 GLU B N 1 ATOM 5843 C CA . GLU B 1 367 ? 20.508 -10.317 -29.006 1.00 25.47 ? 436 GLU B CA 1 ATOM 5844 C C . GLU B 1 367 ? 19.002 -10.144 -28.766 1.00 24.42 ? 436 GLU B C 1 ATOM 5845 O O . GLU B 1 367 ? 18.309 -9.633 -29.635 1.00 25.36 ? 436 GLU B O 1 ATOM 5846 C CB . GLU B 1 367 ? 20.725 -10.895 -30.405 1.00 25.65 ? 436 GLU B CB 1 ATOM 5847 C CG . GLU B 1 367 ? 22.180 -11.042 -30.805 1.00 26.27 ? 436 GLU B CG 1 ATOM 5848 C CD . GLU B 1 367 ? 22.834 -9.719 -31.166 1.00 28.21 ? 436 GLU B CD 1 ATOM 5849 O OE1 . GLU B 1 367 ? 22.116 -8.695 -31.233 1.00 28.97 ? 436 GLU B OE1 1 ATOM 5850 O OE2 . GLU B 1 367 ? 24.069 -9.712 -31.399 1.00 29.74 ? 436 GLU B OE2 1 ATOM 5851 N N . THR B 1 368 ? 18.491 -10.655 -27.643 1.00 23.04 ? 437 THR B N 1 ATOM 5852 C CA . THR B 1 368 ? 17.204 -10.206 -27.074 1.00 22.39 ? 437 THR B CA 1 ATOM 5853 C C . THR B 1 368 ? 17.279 -10.136 -25.543 1.00 20.38 ? 437 THR B C 1 ATOM 5854 O O . THR B 1 368 ? 18.363 -10.152 -24.951 1.00 18.83 ? 437 THR B O 1 ATOM 5855 C CB . THR B 1 368 ? 15.987 -11.089 -27.451 1.00 22.42 ? 437 THR B CB 1 ATOM 5856 O OG1 . THR B 1 368 ? 16.164 -12.418 -26.927 1.00 23.13 ? 437 THR B OG1 1 ATOM 5857 C CG2 . THR B 1 368 ? 15.806 -11.108 -28.951 1.00 25.40 ? 437 THR B CG2 1 ATOM 5858 N N . TRP B 1 369 ? 16.100 -10.045 -24.937 1.00 18.88 ? 438 TRP B N 1 ATOM 5859 C CA . TRP B 1 369 ? 15.976 -9.857 -23.517 1.00 18.16 ? 438 TRP B CA 1 ATOM 5860 C C . TRP B 1 369 ? 16.410 -11.100 -22.770 1.00 17.22 ? 438 TRP B C 1 ATOM 5861 O O . TRP B 1 369 ? 16.317 -12.206 -23.306 1.00 16.56 ? 438 TRP B O 1 ATOM 5862 C CB . TRP B 1 369 ? 14.542 -9.429 -23.169 1.00 18.30 ? 438 TRP B CB 1 ATOM 5863 C CG . TRP B 1 369 ? 13.456 -10.439 -23.426 1.00 17.43 ? 438 TRP B CG 1 ATOM 5864 C CD1 . TRP B 1 369 ? 12.772 -10.673 -24.611 1.00 18.54 ? 438 TRP B CD1 1 ATOM 5865 C CD2 . TRP B 1 369 ? 12.893 -11.309 -22.463 1.00 16.70 ? 438 TRP B CD2 1 ATOM 5866 N NE1 . TRP B 1 369 ? 11.834 -11.658 -24.421 1.00 17.77 ? 438 TRP B NE1 1 ATOM 5867 C CE2 . TRP B 1 369 ? 11.892 -12.068 -23.112 1.00 17.18 ? 438 TRP B CE2 1 ATOM 5868 C CE3 . TRP B 1 369 ? 13.133 -11.524 -21.097 1.00 15.71 ? 438 TRP B CE3 1 ATOM 5869 C CZ2 . TRP B 1 369 ? 11.143 -13.020 -22.440 1.00 17.42 ? 438 TRP B CZ2 1 ATOM 5870 C CZ3 . TRP B 1 369 ? 12.406 -12.458 -20.449 1.00 15.64 ? 438 TRP B CZ3 1 ATOM 5871 C CH2 . TRP B 1 369 ? 11.414 -13.196 -21.104 1.00 16.13 ? 438 TRP B CH2 1 ATOM 5872 N N . HIS B 1 370 ? 16.893 -10.880 -21.552 1.00 16.71 ? 439 HIS B N 1 ATOM 5873 C CA . HIS B 1 370 ? 17.424 -11.910 -20.648 1.00 16.79 ? 439 HIS B CA 1 ATOM 5874 C C . HIS B 1 370 ? 16.888 -11.587 -19.247 1.00 16.98 ? 439 HIS B C 1 ATOM 5875 O O . HIS B 1 370 ? 17.199 -10.563 -18.678 1.00 16.26 ? 439 HIS B O 1 ATOM 5876 C CB . HIS B 1 370 ? 18.959 -11.842 -20.659 1.00 16.99 ? 439 HIS B CB 1 ATOM 5877 C CG . HIS B 1 370 ? 19.650 -13.087 -20.202 1.00 16.67 ? 439 HIS B CG 1 ATOM 5878 N ND1 . HIS B 1 370 ? 20.219 -13.216 -18.949 1.00 17.21 ? 439 HIS B ND1 1 ATOM 5879 C CD2 . HIS B 1 370 ? 19.905 -14.245 -20.850 1.00 16.16 ? 439 HIS B CD2 1 ATOM 5880 C CE1 . HIS B 1 370 ? 20.767 -14.413 -18.837 1.00 15.92 ? 439 HIS B CE1 1 ATOM 5881 N NE2 . HIS B 1 370 ? 20.582 -15.059 -19.975 1.00 17.86 ? 439 HIS B NE2 1 ATOM 5882 N N . SER B 1 371 ? 16.037 -12.450 -18.717 1.00 17.34 ? 440 SER B N 1 ATOM 5883 C CA . SER B 1 371 ? 15.544 -12.294 -17.359 1.00 17.11 ? 440 SER B CA 1 ATOM 5884 C C . SER B 1 371 ? 15.209 -13.685 -16.784 1.00 16.79 ? 440 SER B C 1 ATOM 5885 O O . SER B 1 371 ? 15.610 -14.685 -17.361 1.00 16.94 ? 440 SER B O 1 ATOM 5886 C CB . SER B 1 371 ? 14.336 -11.371 -17.355 1.00 17.01 ? 440 SER B CB 1 ATOM 5887 O OG . SER B 1 371 ? 14.102 -10.851 -16.062 1.00 16.85 ? 440 SER B OG 1 ATOM 5888 N N . ALA B 1 372 ? 14.500 -13.744 -15.661 1.00 16.46 ? 441 ALA B N 1 ATOM 5889 C CA . ALA B 1 372 ? 14.243 -15.027 -14.991 1.00 16.55 ? 441 ALA B CA 1 ATOM 5890 C C . ALA B 1 372 ? 12.908 -15.107 -14.259 1.00 15.63 ? 441 ALA B C 1 ATOM 5891 O O . ALA B 1 372 ? 12.407 -14.103 -13.754 1.00 15.80 ? 441 ALA B O 1 ATOM 5892 C CB . ALA B 1 372 ? 15.400 -15.347 -14.018 1.00 16.62 ? 441 ALA B CB 1 ATOM 5893 N N . ALA B 1 373 ? 12.327 -16.301 -14.253 1.00 15.03 ? 442 ALA B N 1 ATOM 5894 C CA . ALA B 1 373 ? 11.335 -16.688 -13.281 1.00 14.97 ? 442 ALA B CA 1 ATOM 5895 C C . ALA B 1 373 ? 11.993 -17.147 -11.941 1.00 14.92 ? 442 ALA B C 1 ATOM 5896 O O . ALA B 1 373 ? 13.146 -17.525 -11.929 1.00 14.08 ? 442 ALA B O 1 ATOM 5897 C CB . ALA B 1 373 ? 10.531 -17.807 -13.843 1.00 15.30 ? 442 ALA B CB 1 ATOM 5898 N N . THR B 1 374 ? 11.230 -17.147 -10.845 1.00 15.04 ? 443 THR B N 1 ATOM 5899 C CA . THR B 1 374 ? 11.612 -17.837 -9.606 1.00 15.55 ? 443 THR B CA 1 ATOM 5900 C C . THR B 1 374 ? 10.579 -18.939 -9.211 1.00 15.94 ? 443 THR B C 1 ATOM 5901 O O . THR B 1 374 ? 9.376 -18.675 -9.182 1.00 16.47 ? 443 THR B O 1 ATOM 5902 C CB . THR B 1 374 ? 11.760 -16.845 -8.427 1.00 15.29 ? 443 THR B CB 1 ATOM 5903 O OG1 . THR B 1 374 ? 12.532 -15.719 -8.834 1.00 16.53 ? 443 THR B OG1 1 ATOM 5904 C CG2 . THR B 1 374 ? 12.444 -17.489 -7.250 1.00 14.67 ? 443 THR B CG2 1 ATOM 5905 N N . ALA B 1 375 ? 11.053 -20.157 -8.915 1.00 15.80 ? 444 ALA B N 1 ATOM 5906 C CA . ALA B 1 375 ? 10.212 -21.246 -8.353 1.00 15.93 ? 444 ALA B CA 1 ATOM 5907 C C . ALA B 1 375 ? 10.579 -21.515 -6.887 1.00 16.31 ? 444 ALA B C 1 ATOM 5908 O O . ALA B 1 375 ? 11.755 -21.556 -6.556 1.00 16.39 ? 444 ALA B O 1 ATOM 5909 C CB . ALA B 1 375 ? 10.417 -22.512 -9.153 1.00 15.26 ? 444 ALA B CB 1 ATOM 5910 N N . ILE B 1 376 ? 9.595 -21.711 -6.010 1.00 17.29 ? 445 ILE B N 1 ATOM 5911 C CA . ILE B 1 376 ? 9.892 -22.102 -4.618 1.00 17.49 ? 445 ILE B CA 1 ATOM 5912 C C . ILE B 1 376 ? 9.368 -23.499 -4.307 1.00 18.03 ? 445 ILE B C 1 ATOM 5913 O O . ILE B 1 376 ? 8.302 -23.889 -4.784 1.00 17.66 ? 445 ILE B O 1 ATOM 5914 C CB . ILE B 1 376 ? 9.332 -21.113 -3.608 1.00 17.62 ? 445 ILE B CB 1 ATOM 5915 C CG1 . ILE B 1 376 ? 9.900 -19.708 -3.866 1.00 18.84 ? 445 ILE B CG1 1 ATOM 5916 C CG2 . ILE B 1 376 ? 9.641 -21.570 -2.175 1.00 16.78 ? 445 ILE B CG2 1 ATOM 5917 C CD1 . ILE B 1 376 ? 9.150 -18.895 -4.907 1.00 18.09 ? 445 ILE B CD1 1 ATOM 5918 N N . TYR B 1 377 ? 10.172 -24.258 -3.550 1.00 18.70 ? 446 TYR B N 1 ATOM 5919 C CA . TYR B 1 377 ? 9.757 -25.511 -2.892 1.00 18.61 ? 446 TYR B CA 1 ATOM 5920 C C . TYR B 1 377 ? 10.080 -25.399 -1.387 1.00 19.29 ? 446 TYR B C 1 ATOM 5921 O O . TYR B 1 377 ? 11.034 -24.713 -0.987 1.00 19.50 ? 446 TYR B O 1 ATOM 5922 C CB . TYR B 1 377 ? 10.483 -26.697 -3.527 1.00 18.34 ? 446 TYR B CB 1 ATOM 5923 C CG . TYR B 1 377 ? 9.954 -27.050 -4.924 1.00 17.43 ? 446 TYR B CG 1 ATOM 5924 C CD1 . TYR B 1 377 ? 9.191 -28.192 -5.122 1.00 15.60 ? 446 TYR B CD1 1 ATOM 5925 C CD2 . TYR B 1 377 ? 10.187 -26.221 -6.029 1.00 14.94 ? 446 TYR B CD2 1 ATOM 5926 C CE1 . TYR B 1 377 ? 8.673 -28.516 -6.381 1.00 16.65 ? 446 TYR B CE1 1 ATOM 5927 C CE2 . TYR B 1 377 ? 9.661 -26.544 -7.313 1.00 16.79 ? 446 TYR B CE2 1 ATOM 5928 C CZ . TYR B 1 377 ? 8.911 -27.697 -7.489 1.00 17.07 ? 446 TYR B CZ 1 ATOM 5929 O OH . TYR B 1 377 ? 8.366 -28.041 -8.749 1.00 14.73 ? 446 TYR B OH 1 ATOM 5930 N N . CYS B 1 378 ? 9.295 -26.072 -0.556 1.00 19.44 ? 447 CYS B N 1 ATOM 5931 C CA . CYS B 1 378 ? 9.444 -25.982 0.892 1.00 19.62 ? 447 CYS B CA 1 ATOM 5932 C C . CYS B 1 378 ? 9.067 -27.295 1.550 1.00 18.79 ? 447 CYS B C 1 ATOM 5933 O O . CYS B 1 378 ? 8.211 -28.028 1.032 1.00 17.96 ? 447 CYS B O 1 ATOM 5934 C CB . CYS B 1 378 ? 8.526 -24.901 1.473 1.00 20.08 ? 447 CYS B CB 1 ATOM 5935 S SG . CYS B 1 378 ? 8.903 -23.254 0.943 1.00 22.99 ? 447 CYS B SG 1 ATOM 5936 N N . LEU B 1 379 ? 9.692 -27.563 2.705 1.00 18.21 ? 448 LEU B N 1 ATOM 5937 C CA . LEU B 1 379 ? 9.347 -28.727 3.516 1.00 18.14 ? 448 LEU B CA 1 ATOM 5938 C C . LEU B 1 379 ? 7.864 -28.565 3.799 1.00 17.56 ? 448 LEU B C 1 ATOM 5939 O O . LEU B 1 379 ? 7.438 -27.488 4.181 1.00 17.41 ? 448 LEU B O 1 ATOM 5940 C CB . LEU B 1 379 ? 10.160 -28.777 4.830 1.00 18.44 ? 448 LEU B CB 1 ATOM 5941 C CG . LEU B 1 379 ? 10.025 -30.002 5.773 1.00 18.12 ? 448 LEU B CG 1 ATOM 5942 C CD1 . LEU B 1 379 ? 10.812 -31.198 5.261 1.00 15.55 ? 448 LEU B CD1 1 ATOM 5943 C CD2 . LEU B 1 379 ? 10.470 -29.688 7.234 1.00 17.27 ? 448 LEU B CD2 1 ATOM 5944 N N . MET B 1 380 ? 7.080 -29.597 3.523 1.00 17.28 ? 449 MET B N 1 ATOM 5945 C CA . MET B 1 380 ? 5.680 -29.614 3.909 1.00 17.35 ? 449 MET B CA 1 ATOM 5946 C C . MET B 1 380 ? 5.061 -31.003 3.799 1.00 17.09 ? 449 MET B C 1 ATOM 5947 O O . MET B 1 380 ? 5.015 -31.623 2.718 1.00 16.15 ? 449 MET B O 1 ATOM 5948 C CB . MET B 1 380 ? 4.841 -28.574 3.167 1.00 17.74 ? 449 MET B CB 1 ATOM 5949 C CG . MET B 1 380 ? 4.800 -28.677 1.640 1.00 19.07 ? 449 MET B CG 1 ATOM 5950 S SD . MET B 1 380 ? 3.969 -27.210 0.994 1.00 22.52 ? 449 MET B SD 1 ATOM 5951 C CE . MET B 1 380 ? 2.307 -27.454 1.556 1.00 20.91 ? 449 MET B CE 1 ATOM 5952 N N . GLY B 1 381 ? 4.575 -31.468 4.950 1.00 16.57 ? 450 GLY B N 1 ATOM 5953 C CA . GLY B 1 381 ? 4.001 -32.780 5.082 1.00 17.02 ? 450 GLY B CA 1 ATOM 5954 C C . GLY B 1 381 ? 4.953 -33.936 4.872 1.00 17.34 ? 450 GLY B C 1 ATOM 5955 O O . GLY B 1 381 ? 6.200 -33.815 4.985 1.00 17.47 ? 450 GLY B O 1 ATOM 5956 N N . SER B 1 382 ? 4.343 -35.070 4.561 1.00 17.78 ? 451 SER B N 1 ATOM 5957 C CA . SER B 1 382 ? 5.046 -36.309 4.393 1.00 18.93 ? 451 SER B CA 1 ATOM 5958 C C . SER B 1 382 ? 4.943 -36.837 2.956 1.00 19.04 ? 451 SER B C 1 ATOM 5959 O O . SER B 1 382 ? 4.274 -36.248 2.118 1.00 18.28 ? 451 SER B O 1 ATOM 5960 C CB . SER B 1 382 ? 4.482 -37.339 5.349 1.00 19.06 ? 451 SER B CB 1 ATOM 5961 O OG . SER B 1 382 ? 5.533 -38.220 5.688 1.00 22.71 ? 451 SER B OG 1 ATOM 5962 N N . GLY B 1 383 ? 5.653 -37.928 2.683 1.00 19.12 ? 452 GLY B N 1 ATOM 5963 C CA . GLY B 1 383 ? 5.592 -38.565 1.375 1.00 19.65 ? 452 GLY B CA 1 ATOM 5964 C C . GLY B 1 383 ? 6.687 -38.211 0.389 1.00 19.38 ? 452 GLY B C 1 ATOM 5965 O O . GLY B 1 383 ? 7.804 -37.922 0.766 1.00 19.71 ? 452 GLY B O 1 ATOM 5966 N N . GLN B 1 384 ? 6.332 -38.269 -0.889 1.00 19.91 ? 453 GLN B N 1 ATOM 5967 C CA . GLN B 1 384 ? 7.202 -37.969 -2.043 1.00 20.09 ? 453 GLN B CA 1 ATOM 5968 C C . GLN B 1 384 ? 6.916 -36.559 -2.539 1.00 20.20 ? 453 GLN B C 1 ATOM 5969 O O . GLN B 1 384 ? 5.785 -36.107 -2.441 1.00 20.76 ? 453 GLN B O 1 ATOM 5970 C CB . GLN B 1 384 ? 6.856 -38.941 -3.206 1.00 19.91 ? 453 GLN B CB 1 ATOM 5971 C CG . GLN B 1 384 ? 8.035 -39.528 -3.997 0.50 20.09 ? 453 GLN B CG 1 ATOM 5972 C CD . GLN B 1 384 ? 8.160 -41.061 -3.894 0.50 19.56 ? 453 GLN B CD 1 ATOM 5973 O OE1 . GLN B 1 384 ? 7.166 -41.795 -3.933 0.50 18.73 ? 453 GLN B OE1 1 ATOM 5974 N NE2 . GLN B 1 384 ? 9.393 -41.540 -3.789 0.50 19.22 ? 453 GLN B NE2 1 ATOM 5975 N N . LEU B 1 385 ? 7.930 -35.881 -3.084 1.00 20.64 ? 454 LEU B N 1 ATOM 5976 C CA . LEU B 1 385 ? 7.753 -34.671 -3.904 1.00 20.44 ? 454 LEU B CA 1 ATOM 5977 C C . LEU B 1 385 ? 6.961 -35.014 -5.166 1.00 20.37 ? 454 LEU B C 1 ATOM 5978 O O . LEU B 1 385 ? 7.236 -36.029 -5.836 1.00 20.04 ? 454 LEU B O 1 ATOM 5979 C CB . LEU B 1 385 ? 9.114 -34.063 -4.273 1.00 20.37 ? 454 LEU B CB 1 ATOM 5980 C CG . LEU B 1 385 ? 9.188 -32.665 -4.921 1.00 20.86 ? 454 LEU B CG 1 ATOM 5981 C CD1 . LEU B 1 385 ? 10.465 -31.986 -4.454 1.00 21.02 ? 454 LEU B CD1 1 ATOM 5982 C CD2 . LEU B 1 385 ? 9.138 -32.679 -6.488 1.00 19.83 ? 454 LEU B CD2 1 ATOM 5983 N N . LEU B 1 386 ? 5.964 -34.182 -5.482 1.00 19.82 ? 455 LEU B N 1 ATOM 5984 C CA . LEU B 1 386 ? 4.952 -34.573 -6.447 1.00 19.42 ? 455 LEU B CA 1 ATOM 5985 C C . LEU B 1 386 ? 4.952 -33.863 -7.814 1.00 18.63 ? 455 LEU B C 1 ATOM 5986 O O . LEU B 1 386 ? 4.702 -34.515 -8.817 1.00 17.77 ? 455 LEU B O 1 ATOM 5987 C CB . LEU B 1 386 ? 3.559 -34.465 -5.816 1.00 19.42 ? 455 LEU B CB 1 ATOM 5988 C CG . LEU B 1 386 ? 2.815 -35.736 -5.361 1.00 20.96 ? 455 LEU B CG 1 ATOM 5989 C CD1 . LEU B 1 386 ? 3.587 -37.083 -5.607 1.00 22.28 ? 455 LEU B CD1 1 ATOM 5990 C CD2 . LEU B 1 386 ? 2.325 -35.609 -3.911 1.00 20.72 ? 455 LEU B CD2 1 ATOM 5991 N N . TRP B 1 387 ? 5.182 -32.551 -7.871 1.00 17.98 ? 456 TRP B N 1 ATOM 5992 C CA . TRP B 1 387 ? 5.125 -31.869 -9.180 1.00 17.66 ? 456 TRP B CA 1 ATOM 5993 C C . TRP B 1 387 ? 6.318 -30.979 -9.488 1.00 16.69 ? 456 TRP B C 1 ATOM 5994 O O . TRP B 1 387 ? 7.019 -30.462 -8.568 1.00 16.55 ? 456 TRP B O 1 ATOM 5995 C CB . TRP B 1 387 ? 3.812 -31.080 -9.340 1.00 17.86 ? 456 TRP B CB 1 ATOM 5996 C CG . TRP B 1 387 ? 2.977 -31.461 -10.574 1.00 18.11 ? 456 TRP B CG 1 ATOM 5997 C CD1 . TRP B 1 387 ? 3.111 -32.579 -11.345 1.00 18.60 ? 456 TRP B CD1 1 ATOM 5998 C CD2 . TRP B 1 387 ? 1.841 -30.753 -11.104 1.00 17.63 ? 456 TRP B CD2 1 ATOM 5999 N NE1 . TRP B 1 387 ? 2.148 -32.602 -12.330 1.00 17.22 ? 456 TRP B NE1 1 ATOM 6000 C CE2 . TRP B 1 387 ? 1.359 -31.495 -12.209 1.00 17.23 ? 456 TRP B CE2 1 ATOM 6001 C CE3 . TRP B 1 387 ? 1.199 -29.558 -10.767 1.00 17.09 ? 456 TRP B CE3 1 ATOM 6002 C CZ2 . TRP B 1 387 ? 0.262 -31.080 -12.978 1.00 17.65 ? 456 TRP B CZ2 1 ATOM 6003 C CZ3 . TRP B 1 387 ? 0.095 -29.151 -11.528 1.00 17.44 ? 456 TRP B CZ3 1 ATOM 6004 C CH2 . TRP B 1 387 ? -0.362 -29.915 -12.608 1.00 19.02 ? 456 TRP B CH2 1 ATOM 6005 N N . ASP B 1 388 ? 6.511 -30.808 -10.801 1.00 15.37 ? 457 ASP B N 1 ATOM 6006 C CA . ASP B 1 388 ? 7.579 -30.006 -11.369 1.00 14.86 ? 457 ASP B CA 1 ATOM 6007 C C . ASP B 1 388 ? 7.103 -28.588 -11.802 1.00 14.46 ? 457 ASP B C 1 ATOM 6008 O O . ASP B 1 388 ? 5.887 -28.353 -11.898 1.00 14.08 ? 457 ASP B O 1 ATOM 6009 C CB . ASP B 1 388 ? 8.191 -30.776 -12.535 1.00 15.67 ? 457 ASP B CB 1 ATOM 6010 C CG . ASP B 1 388 ? 7.237 -30.935 -13.712 1.00 15.47 ? 457 ASP B CG 1 ATOM 6011 O OD1 . ASP B 1 388 ? 6.169 -31.556 -13.584 1.00 17.59 ? 457 ASP B OD1 1 ATOM 6012 O OD2 . ASP B 1 388 ? 7.566 -30.425 -14.775 1.00 16.70 ? 457 ASP B OD2 1 ATOM 6013 N N . THR B 1 389 ? 8.036 -27.641 -12.017 1.00 13.31 ? 458 THR B N 1 ATOM 6014 C CA . THR B 1 389 ? 7.656 -26.268 -12.437 1.00 13.34 ? 458 THR B CA 1 ATOM 6015 C C . THR B 1 389 ? 8.093 -25.888 -13.874 1.00 12.74 ? 458 THR B C 1 ATOM 6016 O O . THR B 1 389 ? 9.221 -26.154 -14.278 1.00 13.12 ? 458 THR B O 1 ATOM 6017 C CB . THR B 1 389 ? 8.183 -25.206 -11.472 1.00 13.17 ? 458 THR B CB 1 ATOM 6018 O OG1 . THR B 1 389 ? 7.776 -25.528 -10.138 1.00 14.37 ? 458 THR B OG1 1 ATOM 6019 C CG2 . THR B 1 389 ? 7.628 -23.825 -11.851 1.00 12.84 ? 458 THR B CG2 1 ATOM 6020 N N . VAL B 1 390 ? 7.201 -25.274 -14.636 1.00 12.51 ? 459 VAL B N 1 ATOM 6021 C CA . VAL B 1 390 ? 7.563 -24.717 -15.956 1.00 12.43 ? 459 VAL B CA 1 ATOM 6022 C C . VAL B 1 390 ? 7.417 -23.195 -15.847 1.00 12.69 ? 459 VAL B C 1 ATOM 6023 O O . VAL B 1 390 ? 6.721 -22.724 -14.957 1.00 13.38 ? 459 VAL B O 1 ATOM 6024 C CB . VAL B 1 390 ? 6.670 -25.313 -17.132 1.00 11.81 ? 459 VAL B CB 1 ATOM 6025 C CG1 . VAL B 1 390 ? 6.901 -26.780 -17.299 1.00 10.69 ? 459 VAL B CG1 1 ATOM 6026 C CG2 . VAL B 1 390 ? 5.204 -25.038 -16.915 1.00 10.73 ? 459 VAL B CG2 1 ATOM 6027 N N . THR B 1 391 ? 8.034 -22.406 -16.729 1.00 12.90 ? 460 THR B N 1 ATOM 6028 C CA . THR B 1 391 ? 7.898 -20.931 -16.604 1.00 12.69 ? 460 THR B CA 1 ATOM 6029 C C . THR B 1 391 ? 6.672 -20.396 -17.315 1.00 12.86 ? 460 THR B C 1 ATOM 6030 O O . THR B 1 391 ? 6.223 -19.298 -17.047 1.00 13.58 ? 460 THR B O 1 ATOM 6031 C CB . THR B 1 391 ? 9.125 -20.165 -17.084 1.00 13.20 ? 460 THR B CB 1 ATOM 6032 O OG1 . THR B 1 391 ? 9.119 -20.042 -18.528 1.00 12.79 ? 460 THR B OG1 1 ATOM 6033 C CG2 . THR B 1 391 ? 10.442 -20.822 -16.554 1.00 12.53 ? 460 THR B CG2 1 ATOM 6034 N N . GLY B 1 392 ? 6.142 -21.197 -18.229 1.00 13.58 ? 461 GLY B N 1 ATOM 6035 C CA . GLY B 1 392 ? 5.052 -20.800 -19.088 1.00 13.28 ? 461 GLY B CA 1 ATOM 6036 C C . GLY B 1 392 ? 5.356 -19.737 -20.148 1.00 12.97 ? 461 GLY B C 1 ATOM 6037 O O . GLY B 1 392 ? 4.436 -19.313 -20.826 1.00 12.37 ? 461 GLY B O 1 ATOM 6038 N N . VAL B 1 393 ? 6.598 -19.295 -20.296 1.00 12.57 ? 462 VAL B N 1 ATOM 6039 C CA . VAL B 1 393 ? 6.889 -18.112 -21.132 1.00 13.39 ? 462 VAL B CA 1 ATOM 6040 C C . VAL B 1 393 ? 7.381 -18.464 -22.555 1.00 13.93 ? 462 VAL B C 1 ATOM 6041 O O . VAL B 1 393 ? 8.233 -19.306 -22.709 1.00 14.60 ? 462 VAL B O 1 ATOM 6042 C CB . VAL B 1 393 ? 7.929 -17.228 -20.456 1.00 13.14 ? 462 VAL B CB 1 ATOM 6043 C CG1 . VAL B 1 393 ? 8.288 -16.034 -21.343 1.00 11.80 ? 462 VAL B CG1 1 ATOM 6044 C CG2 . VAL B 1 393 ? 7.438 -16.810 -19.044 1.00 13.51 ? 462 VAL B CG2 1 ATOM 6045 N N . ASP B 1 394 ? 6.816 -17.824 -23.576 1.00 14.35 ? 463 ASP B N 1 ATOM 6046 C CA . ASP B 1 394 ? 7.296 -17.904 -24.977 1.00 14.17 ? 463 ASP B CA 1 ATOM 6047 C C . ASP B 1 394 ? 8.006 -16.576 -25.231 1.00 14.51 ? 463 ASP B C 1 ATOM 6048 O O . ASP B 1 394 ? 7.359 -15.546 -25.238 1.00 14.43 ? 463 ASP B O 1 ATOM 6049 C CB . ASP B 1 394 ? 6.088 -18.068 -25.895 1.00 14.25 ? 463 ASP B CB 1 ATOM 6050 C CG . ASP B 1 394 ? 6.407 -17.932 -27.414 1.00 14.92 ? 463 ASP B CG 1 ATOM 6051 O OD1 . ASP B 1 394 ? 5.477 -18.216 -28.177 1.00 15.65 ? 463 ASP B OD1 1 ATOM 6052 O OD2 . ASP B 1 394 ? 7.508 -17.542 -27.867 1.00 16.97 ? 463 ASP B OD2 1 ATOM 6053 N N . MET B 1 395 ? 9.325 -16.596 -25.430 1.00 14.95 ? 464 MET B N 1 ATOM 6054 C CA . MET B 1 395 ? 10.137 -15.365 -25.411 1.00 15.21 ? 464 MET B CA 1 ATOM 6055 C C . MET B 1 395 ? 9.937 -14.434 -26.633 1.00 15.94 ? 464 MET B C 1 ATOM 6056 O O . MET B 1 395 ? 10.518 -13.359 -26.683 1.00 15.90 ? 464 MET B O 1 ATOM 6057 C CB . MET B 1 395 ? 11.636 -15.724 -25.297 1.00 15.29 ? 464 MET B CB 1 ATOM 6058 C CG . MET B 1 395 ? 12.113 -16.320 -23.948 1.00 14.21 ? 464 MET B CG 1 ATOM 6059 S SD . MET B 1 395 ? 13.889 -16.544 -24.007 1.00 14.43 ? 464 MET B SD 1 ATOM 6060 C CE . MET B 1 395 ? 14.484 -14.901 -23.667 1.00 10.17 ? 464 MET B CE 1 ATOM 6061 N N . ALA B 1 396 ? 9.152 -14.858 -27.625 1.00 16.83 ? 465 ALA B N 1 ATOM 6062 C CA . ALA B 1 396 ? 8.909 -14.047 -28.846 1.00 17.52 ? 465 ALA B CA 1 ATOM 6063 C C . ALA B 1 396 ? 7.677 -13.149 -28.716 1.00 17.95 ? 465 ALA B C 1 ATOM 6064 O O . ALA B 1 396 ? 7.435 -12.300 -29.570 1.00 18.50 ? 465 ALA B O 1 ATOM 6065 C CB . ALA B 1 396 ? 8.769 -14.946 -30.074 1.00 16.48 ? 465 ALA B CB 1 ATOM 6066 N N . LEU B 1 397 ? 6.889 -13.331 -27.660 1.00 18.23 ? 466 LEU B N 1 ATOM 6067 C CA . LEU B 1 397 ? 5.666 -12.553 -27.525 1.00 18.53 ? 466 LEU B CA 1 ATOM 6068 C C . LEU B 1 397 ? 6.007 -11.181 -26.941 1.00 19.05 ? 466 LEU B C 1 ATOM 6069 O O . LEU B 1 397 ? 6.988 -11.064 -26.186 1.00 18.35 ? 466 LEU B O 1 ATOM 6070 C CB . LEU B 1 397 ? 4.660 -13.295 -26.656 1.00 18.65 ? 466 LEU B CB 1 ATOM 6071 C CG . LEU B 1 397 ? 4.211 -14.675 -27.135 1.00 17.88 ? 466 LEU B CG 1 ATOM 6072 C CD1 . LEU B 1 397 ? 3.186 -15.236 -26.156 1.00 15.72 ? 466 LEU B CD1 1 ATOM 6073 C CD2 . LEU B 1 397 ? 3.637 -14.630 -28.585 1.00 18.67 ? 466 LEU B CD2 1 ATOM 6074 O OXT . LEU B 1 397 ? 5.337 -10.164 -27.242 1.00 19.47 ? 466 LEU B OXT 1 HETATM 6075 C C1 . NAG C 2 . ? 21.674 -25.061 -68.454 1.00 38.04 ? 1 NAG A C1 1 HETATM 6076 C C2 . NAG C 2 . ? 20.455 -25.875 -68.012 1.00 39.94 ? 1 NAG A C2 1 HETATM 6077 C C3 . NAG C 2 . ? 20.556 -27.313 -68.516 1.00 42.15 ? 1 NAG A C3 1 HETATM 6078 C C4 . NAG C 2 . ? 20.766 -27.340 -70.029 1.00 42.43 ? 1 NAG A C4 1 HETATM 6079 C C5 . NAG C 2 . ? 22.005 -26.503 -70.346 1.00 41.13 ? 1 NAG A C5 1 HETATM 6080 C C6 . NAG C 2 . ? 22.363 -26.460 -71.837 1.00 40.66 ? 1 NAG A C6 1 HETATM 6081 C C7 . NAG C 2 . ? 19.307 -25.258 -65.935 1.00 38.75 ? 1 NAG A C7 1 HETATM 6082 C C8 . NAG C 2 . ? 19.266 -25.393 -64.436 1.00 36.56 ? 1 NAG A C8 1 HETATM 6083 N N2 . NAG C 2 . ? 20.294 -25.896 -66.570 1.00 39.14 ? 1 NAG A N2 1 HETATM 6084 O O3 . NAG C 2 . ? 19.416 -28.060 -68.144 1.00 43.31 ? 1 NAG A O3 1 HETATM 6085 O O4 . NAG C 2 . ? 21.041 -28.661 -70.424 1.00 46.76 ? 1 NAG A O4 1 HETATM 6086 O O5 . NAG C 2 . ? 21.841 -25.188 -69.854 1.00 38.47 ? 1 NAG A O5 1 HETATM 6087 O O6 . NAG C 2 . ? 21.396 -25.703 -72.530 1.00 40.61 ? 1 NAG A O6 1 HETATM 6088 O O7 . NAG C 2 . ? 18.459 -24.580 -66.511 1.00 37.75 ? 1 NAG A O7 1 HETATM 6089 C C1 . NAG D 2 . ? 19.958 -29.350 -71.073 1.00 49.87 ? 2 NAG A C1 1 HETATM 6090 C C2 . NAG D 2 . ? 20.566 -30.552 -71.778 1.00 50.94 ? 2 NAG A C2 1 HETATM 6091 C C3 . NAG D 2 . ? 19.518 -31.481 -72.389 1.00 53.20 ? 2 NAG A C3 1 HETATM 6092 C C4 . NAG D 2 . ? 18.234 -31.620 -71.566 1.00 54.30 ? 2 NAG A C4 1 HETATM 6093 C C5 . NAG D 2 . ? 17.870 -30.396 -70.719 1.00 53.02 ? 2 NAG A C5 1 HETATM 6094 C C6 . NAG D 2 . ? 16.908 -30.756 -69.582 1.00 52.72 ? 2 NAG A C6 1 HETATM 6095 C C7 . NAG D 2 . ? 22.777 -30.253 -72.818 1.00 52.22 ? 2 NAG A C7 1 HETATM 6096 C C8 . NAG D 2 . ? 23.509 -29.670 -74.000 1.00 51.99 ? 2 NAG A C8 1 HETATM 6097 N N2 . NAG D 2 . ? 21.454 -30.072 -72.818 1.00 51.54 ? 2 NAG A N2 1 HETATM 6098 O O3 . NAG D 2 . ? 20.087 -32.768 -72.556 1.00 52.97 ? 2 NAG A O3 1 HETATM 6099 O O4 . NAG D 2 . ? 17.161 -31.863 -72.460 1.00 58.40 ? 2 NAG A O4 1 HETATM 6100 O O5 . NAG D 2 . ? 19.007 -29.799 -70.143 1.00 51.32 ? 2 NAG A O5 1 HETATM 6101 O O6 . NAG D 2 . ? 15.614 -30.305 -69.904 1.00 52.20 ? 2 NAG A O6 1 HETATM 6102 O O7 . NAG D 2 . ? 23.393 -30.851 -71.933 1.00 51.48 ? 2 NAG A O7 1 HETATM 6103 C C1 . BMA E 3 . ? 16.632 -33.200 -72.344 1.00 61.22 ? 3 BMA A C1 1 HETATM 6104 C C2 . BMA E 3 . ? 15.108 -33.165 -72.403 1.00 62.13 ? 3 BMA A C2 1 HETATM 6105 C C3 . BMA E 3 . ? 14.545 -34.584 -72.275 1.00 63.03 ? 3 BMA A C3 1 HETATM 6106 C C4 . BMA E 3 . ? 15.254 -35.575 -73.201 1.00 63.65 ? 3 BMA A C4 1 HETATM 6107 C C5 . BMA E 3 . ? 16.770 -35.402 -73.106 1.00 64.00 ? 3 BMA A C5 1 HETATM 6108 C C6 . BMA E 3 . ? 17.535 -36.297 -74.075 1.00 64.35 ? 3 BMA A C6 1 HETATM 6109 O O2 . BMA E 3 . ? 14.700 -32.545 -73.605 1.00 62.39 ? 3 BMA A O2 1 HETATM 6110 O O3 . BMA E 3 . ? 13.152 -34.594 -72.509 1.00 63.38 ? 3 BMA A O3 1 HETATM 6111 O O4 . BMA E 3 . ? 14.922 -36.890 -72.813 1.00 64.51 ? 3 BMA A O4 1 HETATM 6112 O O5 . BMA E 3 . ? 17.102 -34.050 -73.369 1.00 62.55 ? 3 BMA A O5 1 HETATM 6113 O O6 . BMA E 3 . ? 18.865 -35.824 -74.105 1.00 64.53 ? 3 BMA A O6 1 HETATM 6114 C C1 . MAN F 4 . ? 19.403 -35.795 -75.445 1.00 65.14 ? 4 MAN A C1 1 HETATM 6115 C C2 . MAN F 4 . ? 20.924 -35.836 -75.261 1.00 65.09 ? 4 MAN A C2 1 HETATM 6116 C C3 . MAN F 4 . ? 21.544 -34.444 -75.231 1.00 65.86 ? 4 MAN A C3 1 HETATM 6117 C C4 . MAN F 4 . ? 20.998 -33.591 -76.368 1.00 65.50 ? 4 MAN A C4 1 HETATM 6118 C C5 . MAN F 4 . ? 19.498 -33.423 -76.124 1.00 65.81 ? 4 MAN A C5 1 HETATM 6119 C C6 . MAN F 4 . ? 18.901 -32.332 -77.037 1.00 65.95 ? 4 MAN A C6 1 HETATM 6120 O O2 . MAN F 4 . ? 21.540 -36.632 -76.246 1.00 64.86 ? 4 MAN A O2 1 HETATM 6121 O O3 . MAN F 4 . ? 22.956 -34.506 -75.245 1.00 67.34 ? 4 MAN A O3 1 HETATM 6122 O O4 . MAN F 4 . ? 21.671 -32.352 -76.430 1.00 64.68 ? 4 MAN A O4 1 HETATM 6123 O O5 . MAN F 4 . ? 18.897 -34.712 -76.247 1.00 65.96 ? 4 MAN A O5 1 HETATM 6124 O O6 . MAN F 4 . ? 17.483 -32.347 -77.168 1.00 66.77 ? 4 MAN A O6 1 HETATM 6125 C C1 . MAN G 4 . ? 16.844 -31.034 -77.071 1.00 67.42 ? 5 MAN A C1 1 HETATM 6126 C C2 . MAN G 4 . ? 15.452 -31.034 -77.737 1.00 67.71 ? 5 MAN A C2 1 HETATM 6127 C C3 . MAN G 4 . ? 15.339 -30.507 -79.190 1.00 67.95 ? 5 MAN A C3 1 HETATM 6128 C C4 . MAN G 4 . ? 16.442 -29.543 -79.626 1.00 68.05 ? 5 MAN A C4 1 HETATM 6129 C C5 . MAN G 4 . ? 17.779 -29.803 -78.930 1.00 68.04 ? 5 MAN A C5 1 HETATM 6130 C C6 . MAN G 4 . ? 18.760 -28.657 -79.179 1.00 68.32 ? 5 MAN A C6 1 HETATM 6131 O O2 . MAN G 4 . ? 14.561 -30.328 -76.897 1.00 67.53 ? 5 MAN A O2 1 HETATM 6132 O O3 . MAN G 4 . ? 14.106 -29.845 -79.417 1.00 67.39 ? 5 MAN A O3 1 HETATM 6133 O O4 . MAN G 4 . ? 16.572 -29.618 -81.033 1.00 67.57 ? 5 MAN A O4 1 HETATM 6134 O O5 . MAN G 4 . ? 17.594 -29.923 -77.536 1.00 67.59 ? 5 MAN A O5 1 HETATM 6135 O O6 . MAN G 4 . ? 19.965 -28.860 -78.462 1.00 68.30 ? 5 MAN A O6 1 HETATM 6136 C C1 . MAN H 4 . ? 23.443 -34.252 -73.912 1.00 69.11 ? 6 MAN A C1 1 HETATM 6137 C C2 . MAN H 4 . ? 24.946 -34.009 -73.954 1.00 69.65 ? 6 MAN A C2 1 HETATM 6138 C C3 . MAN H 4 . ? 25.712 -35.303 -74.206 1.00 69.95 ? 6 MAN A C3 1 HETATM 6139 C C4 . MAN H 4 . ? 25.236 -36.406 -73.263 1.00 69.93 ? 6 MAN A C4 1 HETATM 6140 C C5 . MAN H 4 . ? 23.717 -36.544 -73.336 1.00 70.02 ? 6 MAN A C5 1 HETATM 6141 C C6 . MAN H 4 . ? 23.171 -37.612 -72.388 1.00 70.03 ? 6 MAN A C6 1 HETATM 6142 O O2 . MAN H 4 . ? 25.338 -33.460 -72.716 1.00 70.17 ? 6 MAN A O2 1 HETATM 6143 O O3 . MAN H 4 . ? 27.096 -35.075 -74.047 1.00 69.37 ? 6 MAN A O3 1 HETATM 6144 O O4 . MAN H 4 . ? 25.832 -37.621 -73.644 1.00 70.16 ? 6 MAN A O4 1 HETATM 6145 O O5 . MAN H 4 . ? 23.130 -35.298 -73.011 1.00 69.83 ? 6 MAN A O5 1 HETATM 6146 O O6 . MAN H 4 . ? 22.691 -37.024 -71.199 1.00 69.54 ? 6 MAN A O6 1 HETATM 6147 S S . SO4 I 5 . ? 26.793 -16.893 -34.225 1.00 41.29 ? 467 SO4 A S 1 HETATM 6148 O O1 . SO4 I 5 . ? 28.038 -16.385 -34.804 1.00 39.76 ? 467 SO4 A O1 1 HETATM 6149 O O2 . SO4 I 5 . ? 25.623 -16.250 -34.865 1.00 38.90 ? 467 SO4 A O2 1 HETATM 6150 O O3 . SO4 I 5 . ? 26.713 -18.337 -34.420 1.00 37.17 ? 467 SO4 A O3 1 HETATM 6151 O O4 . SO4 I 5 . ? 26.778 -16.580 -32.793 1.00 40.91 ? 467 SO4 A O4 1 HETATM 6152 C C1 . EDO J 6 . ? 28.906 -36.086 -56.045 1.00 18.65 ? 468 EDO A C1 1 HETATM 6153 O O1 . EDO J 6 . ? 28.455 -34.864 -56.645 1.00 13.96 ? 468 EDO A O1 1 HETATM 6154 C C2 . EDO J 6 . ? 29.261 -37.129 -57.090 1.00 19.34 ? 468 EDO A C2 1 HETATM 6155 O O2 . EDO J 6 . ? 28.174 -38.035 -57.336 1.00 22.06 ? 468 EDO A O2 1 HETATM 6156 C C1 . GOL K 7 . ? 10.472 -21.410 -26.813 1.00 32.74 ? 469 GOL A C1 1 HETATM 6157 O O1 . GOL K 7 . ? 11.582 -22.241 -27.121 1.00 33.42 ? 469 GOL A O1 1 HETATM 6158 C C2 . GOL K 7 . ? 10.874 -19.954 -27.064 1.00 31.81 ? 469 GOL A C2 1 HETATM 6159 O O2 . GOL K 7 . ? 10.709 -19.125 -25.929 1.00 29.42 ? 469 GOL A O2 1 HETATM 6160 C C3 . GOL K 7 . ? 10.074 -19.409 -28.238 1.00 30.58 ? 469 GOL A C3 1 HETATM 6161 O O3 . GOL K 7 . ? 10.283 -18.036 -28.427 1.00 27.24 ? 469 GOL A O3 1 HETATM 6162 CA CA . CA L 8 . ? 18.065 -10.653 -37.509 1.00 40.46 ? 470 CA A CA 1 HETATM 6163 C C1 . NAG M 2 . ? 18.795 -22.218 19.998 1.00 35.68 ? 1 NAG B C1 1 HETATM 6164 C C2 . NAG M 2 . ? 17.959 -23.387 19.459 1.00 38.13 ? 1 NAG B C2 1 HETATM 6165 C C3 . NAG M 2 . ? 16.483 -23.286 19.851 1.00 41.03 ? 1 NAG B C3 1 HETATM 6166 C C4 . NAG M 2 . ? 16.391 -23.108 21.365 1.00 42.11 ? 1 NAG B C4 1 HETATM 6167 C C5 . NAG M 2 . ? 17.153 -21.826 21.735 1.00 41.02 ? 1 NAG B C5 1 HETATM 6168 C C6 . NAG M 2 . ? 17.136 -21.505 23.229 1.00 40.95 ? 1 NAG B C6 1 HETATM 6169 C C7 . NAG M 2 . ? 18.643 -24.488 17.371 1.00 37.49 ? 1 NAG B C7 1 HETATM 6170 C C8 . NAG M 2 . ? 18.575 -24.433 15.881 1.00 36.85 ? 1 NAG B C8 1 HETATM 6171 N N2 . NAG M 2 . ? 18.030 -23.493 18.009 1.00 37.73 ? 1 NAG B N2 1 HETATM 6172 O O3 . NAG M 2 . ? 15.741 -24.415 19.389 1.00 39.81 ? 1 NAG B O3 1 HETATM 6173 O O4 . NAG M 2 . ? 15.033 -22.956 21.714 1.00 46.98 ? 1 NAG B O4 1 HETATM 6174 O O5 . NAG M 2 . ? 18.507 -21.905 21.344 1.00 37.51 ? 1 NAG B O5 1 HETATM 6175 O O6 . NAG M 2 . ? 17.796 -22.523 23.949 1.00 41.75 ? 1 NAG B O6 1 HETATM 6176 O O7 . NAG M 2 . ? 19.245 -25.407 17.926 1.00 37.45 ? 1 NAG B O7 1 HETATM 6177 C C1 . NAG N 2 . ? 14.474 -24.055 22.459 1.00 51.53 ? 2 NAG B C1 1 HETATM 6178 C C2 . NAG N 2 . ? 13.282 -23.518 23.248 1.00 53.44 ? 2 NAG B C2 1 HETATM 6179 C C3 . NAG N 2 . ? 12.402 -24.605 23.877 1.00 55.75 ? 2 NAG B C3 1 HETATM 6180 C C4 . NAG N 2 . ? 12.396 -25.948 23.128 1.00 57.73 ? 2 NAG B C4 1 HETATM 6181 C C5 . NAG N 2 . ? 13.653 -26.253 22.308 1.00 56.23 ? 2 NAG B C5 1 HETATM 6182 C C6 . NAG N 2 . ? 13.416 -27.388 21.309 1.00 56.10 ? 2 NAG B C6 1 HETATM 6183 C C7 . NAG N 2 . ? 13.629 -21.313 24.286 1.00 54.29 ? 2 NAG B C7 1 HETATM 6184 C C8 . NAG N 2 . ? 14.214 -20.593 25.472 1.00 54.80 ? 2 NAG B C8 1 HETATM 6185 N N2 . NAG N 2 . ? 13.771 -22.638 24.300 1.00 53.83 ? 2 NAG B N2 1 HETATM 6186 O O3 . NAG N 2 . ? 11.077 -24.112 23.973 1.00 54.74 ? 2 NAG B O3 1 HETATM 6187 O O4 . NAG N 2 . ? 12.177 -27.007 24.051 1.00 61.27 ? 2 NAG B O4 1 HETATM 6188 O O5 . NAG N 2 . ? 14.057 -25.097 21.610 1.00 53.68 ? 2 NAG B O5 1 HETATM 6189 O O6 . NAG N 2 . ? 12.910 -26.903 20.080 1.00 55.72 ? 2 NAG B O6 1 HETATM 6190 O O7 . NAG N 2 . ? 13.067 -20.686 23.387 1.00 52.66 ? 2 NAG B O7 1 HETATM 6191 C C1 . BMA O 3 . ? 10.826 -27.492 23.923 1.00 64.79 ? 3 BMA B C1 1 HETATM 6192 C C2 . BMA O 3 . ? 10.783 -29.000 24.089 1.00 65.69 ? 3 BMA B C2 1 HETATM 6193 C C3 . BMA O 3 . ? 9.370 -29.467 23.747 1.00 66.42 ? 3 BMA B C3 1 HETATM 6194 C C4 . BMA O 3 . ? 8.303 -28.676 24.509 1.00 67.13 ? 3 BMA B C4 1 HETATM 6195 C C5 . BMA O 3 . ? 8.594 -27.177 24.526 1.00 67.87 ? 3 BMA B C5 1 HETATM 6196 C C6 . BMA O 3 . ? 7.705 -26.444 25.520 1.00 69.15 ? 3 BMA B C6 1 HETATM 6197 O O2 . BMA O 3 . ? 11.124 -29.325 25.420 1.00 65.95 ? 3 BMA B O2 1 HETATM 6198 O O3 . BMA O 3 . ? 9.246 -30.844 24.020 1.00 67.04 ? 3 BMA B O3 1 HETATM 6199 O O4 . BMA O 3 . ? 7.054 -28.856 23.882 1.00 67.28 ? 3 BMA B O4 1 HETATM 6200 O O5 . BMA O 3 . ? 9.945 -26.930 24.868 1.00 66.31 ? 3 BMA B O5 1 HETATM 6201 O O6 . BMA O 3 . ? 8.133 -25.100 25.535 1.00 70.38 ? 3 BMA B O6 1 HETATM 6202 C C1 . MAN P 4 . ? 7.811 -24.474 26.785 1.00 71.35 ? 4 MAN B C1 1 HETATM 6203 C C2 . MAN P 4 . ? 7.755 -22.977 26.502 1.00 71.74 ? 4 MAN B C2 1 HETATM 6204 C C3 . MAN P 4 . ? 9.128 -22.315 26.528 1.00 72.15 ? 4 MAN B C3 1 HETATM 6205 C C4 . MAN P 4 . ? 9.905 -22.742 27.765 1.00 71.99 ? 4 MAN B C4 1 HETATM 6206 C C5 . MAN P 4 . ? 10.022 -24.265 27.753 1.00 72.56 ? 4 MAN B C5 1 HETATM 6207 C C6 . MAN P 4 . ? 10.874 -24.772 28.920 1.00 73.24 ? 4 MAN B C6 1 HETATM 6208 O O2 . MAN P 4 . ? 6.903 -22.349 27.429 1.00 71.80 ? 4 MAN B O2 1 HETATM 6209 O O3 . MAN P 4 . ? 8.962 -20.916 26.537 1.00 73.06 ? 4 MAN B O3 1 HETATM 6210 O O4 . MAN P 4 . ? 11.166 -22.101 27.806 1.00 70.71 ? 4 MAN B O4 1 HETATM 6211 O O5 . MAN P 4 . ? 8.713 -24.813 27.830 1.00 72.17 ? 4 MAN B O5 1 HETATM 6212 O O6 . MAN P 4 . ? 11.180 -26.156 28.832 1.00 74.30 ? 4 MAN B O6 1 HETATM 6213 C C1 . MAN Q 4 . ? 12.500 -26.385 28.288 1.00 74.75 ? 5 MAN B C1 1 HETATM 6214 C C2 . MAN Q 4 . ? 12.722 -27.879 28.077 1.00 74.96 ? 5 MAN B C2 1 HETATM 6215 C C3 . MAN Q 4 . ? 12.876 -28.598 29.410 1.00 75.41 ? 5 MAN B C3 1 HETATM 6216 C C4 . MAN Q 4 . ? 14.038 -28.014 30.199 1.00 75.27 ? 5 MAN B C4 1 HETATM 6217 C C5 . MAN Q 4 . ? 13.933 -26.487 30.286 1.00 75.33 ? 5 MAN B C5 1 HETATM 6218 C C6 . MAN Q 4 . ? 15.264 -25.881 30.727 1.00 75.55 ? 5 MAN B C6 1 HETATM 6219 O O2 . MAN Q 4 . ? 13.887 -28.067 27.305 1.00 74.72 ? 5 MAN B O2 1 HETATM 6220 O O3 . MAN Q 4 . ? 13.077 -29.979 29.206 1.00 75.55 ? 5 MAN B O3 1 HETATM 6221 O O4 . MAN Q 4 . ? 14.025 -28.590 31.488 1.00 74.41 ? 5 MAN B O4 1 HETATM 6222 O O5 . MAN Q 4 . ? 13.561 -25.851 29.069 1.00 74.82 ? 5 MAN B O5 1 HETATM 6223 O O6 . MAN Q 4 . ? 15.072 -24.524 31.081 1.00 76.03 ? 5 MAN B O6 1 HETATM 6224 C C1 . MAN R 4 . ? 9.414 -20.309 25.315 1.00 73.66 ? 6 MAN B C1 1 HETATM 6225 C C2 . MAN R 4 . ? 9.407 -18.805 25.551 1.00 73.84 ? 6 MAN B C2 1 HETATM 6226 C C3 . MAN R 4 . ? 7.977 -18.294 25.695 1.00 73.77 ? 6 MAN B C3 1 HETATM 6227 C C4 . MAN R 4 . ? 7.106 -18.773 24.540 1.00 74.06 ? 6 MAN B C4 1 HETATM 6228 C C5 . MAN R 4 . ? 7.243 -20.283 24.332 1.00 74.51 ? 6 MAN B C5 1 HETATM 6229 C C6 . MAN R 4 . ? 6.461 -20.792 23.114 1.00 74.03 ? 6 MAN B C6 1 HETATM 6230 O O2 . MAN R 4 . ? 10.057 -18.133 24.494 1.00 73.57 ? 6 MAN B O2 1 HETATM 6231 O O3 . MAN R 4 . ? 7.990 -16.885 25.742 1.00 73.76 ? 6 MAN B O3 1 HETATM 6232 O O4 . MAN R 4 . ? 5.763 -18.492 24.849 1.00 74.02 ? 6 MAN B O4 1 HETATM 6233 O O5 . MAN R 4 . ? 8.612 -20.637 24.195 1.00 74.62 ? 6 MAN B O5 1 HETATM 6234 O O6 . MAN R 4 . ? 6.691 -19.995 21.971 1.00 73.83 ? 6 MAN B O6 1 HETATM 6235 S S . SO4 S 5 . ? 26.815 -17.006 -14.289 1.00 30.97 ? 467 SO4 B S 1 HETATM 6236 O O1 . SO4 S 5 . ? 27.267 -17.607 -15.561 1.00 28.04 ? 467 SO4 B O1 1 HETATM 6237 O O2 . SO4 S 5 . ? 25.361 -16.955 -14.209 1.00 23.81 ? 467 SO4 B O2 1 HETATM 6238 O O3 . SO4 S 5 . ? 27.294 -17.858 -13.187 1.00 29.05 ? 467 SO4 B O3 1 HETATM 6239 O O4 . SO4 S 5 . ? 27.413 -15.670 -14.157 1.00 27.77 ? 467 SO4 B O4 1 HETATM 6240 C C1 . EDO T 6 . ? 7.778 -34.726 -9.887 1.00 30.77 ? 468 EDO B C1 1 HETATM 6241 O O1 . EDO T 6 . ? 8.854 -33.916 -10.370 1.00 29.03 ? 468 EDO B O1 1 HETATM 6242 C C2 . EDO T 6 . ? 8.256 -35.685 -8.792 1.00 30.50 ? 468 EDO B C2 1 HETATM 6243 O O2 . EDO T 6 . ? 9.374 -36.465 -9.251 1.00 31.27 ? 468 EDO B O2 1 HETATM 6244 C C1 . GOL U 7 . ? 38.925 -4.135 2.359 1.00 39.23 ? 469 GOL B C1 1 HETATM 6245 O O1 . GOL U 7 . ? 40.057 -4.742 1.799 1.00 38.10 ? 469 GOL B O1 1 HETATM 6246 C C2 . GOL U 7 . ? 39.240 -3.389 3.640 1.00 39.77 ? 469 GOL B C2 1 HETATM 6247 O O2 . GOL U 7 . ? 39.881 -4.296 4.513 1.00 40.53 ? 469 GOL B O2 1 HETATM 6248 C C3 . GOL U 7 . ? 37.944 -2.850 4.262 1.00 39.19 ? 469 GOL B C3 1 HETATM 6249 O O3 . GOL U 7 . ? 37.435 -1.717 3.600 1.00 37.78 ? 469 GOL B O3 1 HETATM 6250 C C1 . GOL V 7 . ? 7.052 -14.730 9.816 1.00 34.87 ? 470 GOL B C1 1 HETATM 6251 O O1 . GOL V 7 . ? 5.957 -14.820 10.713 1.00 38.99 ? 470 GOL B O1 1 HETATM 6252 C C2 . GOL V 7 . ? 6.552 -14.750 8.399 1.00 31.34 ? 470 GOL B C2 1 HETATM 6253 O O2 . GOL V 7 . ? 5.646 -15.833 8.350 1.00 32.85 ? 470 GOL B O2 1 HETATM 6254 C C3 . GOL V 7 . ? 7.714 -14.848 7.401 1.00 28.72 ? 470 GOL B C3 1 HETATM 6255 O O3 . GOL V 7 . ? 8.914 -15.371 7.950 1.00 23.68 ? 470 GOL B O3 1 HETATM 6256 C C1 . GOL W 7 . ? 24.417 -33.266 -20.220 1.00 28.36 ? 471 GOL B C1 1 HETATM 6257 O O1 . GOL W 7 . ? 25.776 -33.628 -20.068 1.00 26.15 ? 471 GOL B O1 1 HETATM 6258 C C2 . GOL W 7 . ? 23.870 -33.692 -21.593 1.00 29.55 ? 471 GOL B C2 1 HETATM 6259 O O2 . GOL W 7 . ? 24.400 -32.840 -22.602 1.00 26.36 ? 471 GOL B O2 1 HETATM 6260 C C3 . GOL W 7 . ? 22.341 -33.640 -21.618 1.00 29.91 ? 471 GOL B C3 1 HETATM 6261 O O3 . GOL W 7 . ? 21.878 -32.364 -21.205 1.00 31.28 ? 471 GOL B O3 1 HETATM 6262 CA CA . CA X 8 . ? 33.070 -25.782 -10.583 1.00 36.43 ? 472 CA B CA 1 HETATM 6263 O O . HOH Y 9 . ? 37.122 -40.734 -27.229 1.00 3.23 ? 7 HOH A O 1 HETATM 6264 O O . HOH Y 9 . ? 18.815 -17.136 -30.650 1.00 9.49 ? 11 HOH A O 1 HETATM 6265 O O . HOH Y 9 . ? 20.495 -36.526 -28.831 1.00 10.43 ? 12 HOH A O 1 HETATM 6266 O O . HOH Y 9 . ? 48.718 -19.880 -35.484 1.00 15.83 ? 15 HOH A O 1 HETATM 6267 O O . HOH Y 9 . ? 38.346 -6.594 -41.351 1.00 9.97 ? 16 HOH A O 1 HETATM 6268 O O . HOH Y 9 . ? 21.056 -24.898 -28.789 1.00 25.57 ? 19 HOH A O 1 HETATM 6269 O O . HOH Y 9 . ? 29.303 -20.370 -31.009 1.00 11.42 ? 24 HOH A O 1 HETATM 6270 O O . HOH Y 9 . ? 45.151 -17.336 -38.926 1.00 15.49 ? 25 HOH A O 1 HETATM 6271 O O . HOH Y 9 . ? 31.420 -36.509 -43.291 1.00 12.06 ? 27 HOH A O 1 HETATM 6272 O O . HOH Y 9 . ? 12.820 -38.912 -43.277 1.00 21.74 ? 29 HOH A O 1 HETATM 6273 O O . HOH Y 9 . ? 10.240 -12.982 -44.876 1.00 19.39 ? 30 HOH A O 1 HETATM 6274 O O . HOH Y 9 . ? 9.921 -35.343 -38.272 1.00 19.43 ? 38 HOH A O 1 HETATM 6275 O O . HOH Y 9 . ? 41.686 -25.565 -22.082 1.00 23.64 ? 42 HOH A O 1 HETATM 6276 O O . HOH Y 9 . ? 39.607 -4.263 -50.806 1.00 22.45 ? 43 HOH A O 1 HETATM 6277 O O . HOH Y 9 . ? 16.543 -20.063 -44.004 1.00 22.74 ? 44 HOH A O 1 HETATM 6278 O O . HOH Y 9 . ? 27.706 -18.731 -54.071 1.00 13.63 ? 47 HOH A O 1 HETATM 6279 O O . HOH Y 9 . ? 9.313 -20.160 -54.886 1.00 19.56 ? 50 HOH A O 1 HETATM 6280 O O . HOH Y 9 . ? 32.196 -18.045 -38.404 1.00 21.17 ? 51 HOH A O 1 HETATM 6281 O O . HOH Y 9 . ? 33.522 -41.070 -20.706 1.00 21.39 ? 55 HOH A O 1 HETATM 6282 O O . HOH Y 9 . ? 28.577 -18.834 -22.037 1.00 33.44 ? 57 HOH A O 1 HETATM 6283 O O . HOH Y 9 . ? 21.619 -17.226 -44.266 1.00 15.25 ? 61 HOH A O 1 HETATM 6284 O O . HOH Y 9 . ? 27.391 -40.479 -57.456 1.00 20.18 ? 62 HOH A O 1 HETATM 6285 O O . HOH Y 9 . ? 9.264 -42.184 -33.557 1.00 28.29 ? 63 HOH A O 1 HETATM 6286 O O . HOH Y 9 . ? 25.006 -41.403 -59.072 1.00 12.39 ? 64 HOH A O 1 HETATM 6287 O O . HOH Y 9 . ? 34.378 -23.283 -25.109 1.00 22.47 ? 65 HOH A O 1 HETATM 6288 O O . HOH Y 9 . ? 26.776 -25.564 -48.860 1.00 18.12 ? 68 HOH A O 1 HETATM 6289 O O . HOH Y 9 . ? 36.685 -24.696 -58.138 1.00 19.51 ? 69 HOH A O 1 HETATM 6290 O O . HOH Y 9 . ? 17.804 -11.875 -41.621 1.00 10.21 ? 471 HOH A O 1 HETATM 6291 O O . HOH Y 9 . ? 28.756 -34.976 -32.586 1.00 18.18 ? 472 HOH A O 1 HETATM 6292 O O . HOH Y 9 . ? 49.382 -30.451 -25.798 1.00 9.05 ? 473 HOH A O 1 HETATM 6293 O O . HOH Y 9 . ? 15.873 -19.990 -38.219 1.00 11.56 ? 474 HOH A O 1 HETATM 6294 O O . HOH Y 9 . ? 41.255 -29.845 -26.841 1.00 13.45 ? 475 HOH A O 1 HETATM 6295 O O . HOH Y 9 . ? 26.103 -26.863 -54.440 1.00 18.47 ? 476 HOH A O 1 HETATM 6296 O O . HOH Y 9 . ? 30.885 -36.317 -24.265 1.00 20.06 ? 477 HOH A O 1 HETATM 6297 O O . HOH Y 9 . ? 29.405 -13.499 -43.509 1.00 12.75 ? 478 HOH A O 1 HETATM 6298 O O . HOH Y 9 . ? 19.168 -1.002 -47.412 1.00 18.37 ? 479 HOH A O 1 HETATM 6299 O O . HOH Y 9 . ? 5.781 -9.608 -45.856 1.00 20.00 ? 480 HOH A O 1 HETATM 6300 O O . HOH Y 9 . ? 10.232 -40.017 -50.052 1.00 16.91 ? 481 HOH A O 1 HETATM 6301 O O . HOH Y 9 . ? 33.525 -25.112 -32.236 1.00 17.66 ? 482 HOH A O 1 HETATM 6302 O O . HOH Y 9 . ? 15.656 -23.453 -64.034 1.00 28.40 ? 483 HOH A O 1 HETATM 6303 O O . HOH Y 9 . ? 12.144 -8.129 -37.566 1.00 24.04 ? 484 HOH A O 1 HETATM 6304 O O . HOH Y 9 . ? 6.104 -16.255 -50.281 1.00 24.28 ? 485 HOH A O 1 HETATM 6305 O O . HOH Y 9 . ? 38.215 -20.961 -58.969 1.00 16.04 ? 486 HOH A O 1 HETATM 6306 O O . HOH Y 9 . ? 26.243 -21.579 -50.491 1.00 9.75 ? 487 HOH A O 1 HETATM 6307 O O . HOH Y 9 . ? 41.240 -37.087 -27.982 1.00 18.52 ? 488 HOH A O 1 HETATM 6308 O O . HOH Y 9 . ? 19.264 -30.587 -67.262 1.00 19.24 ? 489 HOH A O 1 HETATM 6309 O O . HOH Y 9 . ? 18.924 -29.255 -57.234 1.00 27.33 ? 490 HOH A O 1 HETATM 6310 O O . HOH Y 9 . ? 32.619 -22.466 -42.442 1.00 25.93 ? 491 HOH A O 1 HETATM 6311 O O . HOH Y 9 . ? 27.611 -12.319 -36.757 1.00 22.29 ? 492 HOH A O 1 HETATM 6312 O O . HOH Y 9 . ? 32.190 -24.279 -63.686 1.00 19.56 ? 493 HOH A O 1 HETATM 6313 O O . HOH Y 9 . ? 20.378 -24.352 -55.244 1.00 21.71 ? 494 HOH A O 1 HETATM 6314 O O . HOH Y 9 . ? 24.454 -27.537 -59.676 1.00 27.20 ? 495 HOH A O 1 HETATM 6315 O O . HOH Y 9 . ? 22.258 -33.273 -28.763 1.00 19.57 ? 496 HOH A O 1 HETATM 6316 O O . HOH Y 9 . ? 29.781 -22.818 -19.171 1.00 13.20 ? 497 HOH A O 1 HETATM 6317 O O . HOH Y 9 . ? 45.275 -35.206 -40.414 1.00 15.87 ? 498 HOH A O 1 HETATM 6318 O O . HOH Y 9 . ? 42.074 -6.596 -52.760 1.00 28.75 ? 499 HOH A O 1 HETATM 6319 O O . HOH Y 9 . ? 28.648 -40.917 -47.878 1.00 27.41 ? 500 HOH A O 1 HETATM 6320 O O . HOH Y 9 . ? 27.952 -23.168 -41.656 1.00 9.52 ? 501 HOH A O 1 HETATM 6321 O O . HOH Y 9 . ? 41.796 -8.431 -33.975 1.00 24.18 ? 502 HOH A O 1 HETATM 6322 O O . HOH Y 9 . ? 8.321 -16.849 -51.808 1.00 15.80 ? 503 HOH A O 1 HETATM 6323 O O . HOH Y 9 . ? 7.694 -16.982 -36.516 1.00 13.20 ? 504 HOH A O 1 HETATM 6324 O O . HOH Y 9 . ? 4.751 -17.938 -36.040 1.00 16.94 ? 505 HOH A O 1 HETATM 6325 O O . HOH Y 9 . ? 23.150 -24.337 -57.140 1.00 11.44 ? 506 HOH A O 1 HETATM 6326 O O . HOH Y 9 . ? 32.440 -20.295 -34.187 1.00 22.81 ? 507 HOH A O 1 HETATM 6327 O O . HOH Y 9 . ? 41.246 -23.607 -28.123 1.00 16.59 ? 508 HOH A O 1 HETATM 6328 O O . HOH Y 9 . ? 25.135 -5.102 -59.470 1.00 21.57 ? 509 HOH A O 1 HETATM 6329 O O . HOH Y 9 . ? 35.450 -36.643 -23.244 1.00 19.82 ? 510 HOH A O 1 HETATM 6330 O O . HOH Y 9 . ? 9.913 -34.313 -59.221 1.00 24.37 ? 511 HOH A O 1 HETATM 6331 O O . HOH Y 9 . ? 40.787 -11.886 -35.822 1.00 19.91 ? 512 HOH A O 1 HETATM 6332 O O . HOH Y 9 . ? 7.626 -16.754 -54.544 1.00 21.82 ? 513 HOH A O 1 HETATM 6333 O O . HOH Y 9 . ? 15.348 -4.622 -34.933 1.00 38.43 ? 514 HOH A O 1 HETATM 6334 O O . HOH Y 9 . ? 12.723 -14.956 -44.835 1.00 22.19 ? 515 HOH A O 1 HETATM 6335 O O . HOH Y 9 . ? 37.185 -2.965 -36.405 1.00 33.37 ? 516 HOH A O 1 HETATM 6336 O O . HOH Y 9 . ? 42.612 -18.498 -37.945 1.00 14.95 ? 517 HOH A O 1 HETATM 6337 O O . HOH Y 9 . ? 8.051 -35.088 -39.317 1.00 32.84 ? 518 HOH A O 1 HETATM 6338 O O . HOH Y 9 . ? 18.750 -21.354 -68.009 1.00 24.68 ? 519 HOH A O 1 HETATM 6339 O O . HOH Y 9 . ? 29.550 -16.464 -65.188 1.00 43.97 ? 520 HOH A O 1 HETATM 6340 O O . HOH Y 9 . ? 7.732 -20.049 -35.745 1.00 20.65 ? 521 HOH A O 1 HETATM 6341 O O . HOH Y 9 . ? 36.433 -44.124 -28.933 1.00 14.94 ? 522 HOH A O 1 HETATM 6342 O O . HOH Y 9 . ? 38.865 -33.500 -47.474 1.00 16.71 ? 523 HOH A O 1 HETATM 6343 O O . HOH Y 9 . ? 16.488 -16.806 -65.211 1.00 24.63 ? 524 HOH A O 1 HETATM 6344 O O . HOH Y 9 . ? 42.849 -23.374 -25.008 1.00 14.05 ? 525 HOH A O 1 HETATM 6345 O O . HOH Y 9 . ? 23.767 -28.249 -27.051 1.00 25.68 ? 526 HOH A O 1 HETATM 6346 O O . HOH Y 9 . ? 19.964 -16.954 -33.269 1.00 23.57 ? 527 HOH A O 1 HETATM 6347 O O . HOH Y 9 . ? 15.126 -2.456 -37.443 1.00 25.29 ? 528 HOH A O 1 HETATM 6348 O O . HOH Y 9 . ? 16.674 -11.874 -36.167 1.00 21.66 ? 529 HOH A O 1 HETATM 6349 O O . HOH Y 9 . ? 42.943 -6.379 -45.273 1.00 21.83 ? 530 HOH A O 1 HETATM 6350 O O . HOH Y 9 . ? 20.492 -6.109 -47.078 1.00 33.50 ? 531 HOH A O 1 HETATM 6351 O O . HOH Y 9 . ? 32.620 -12.197 -52.472 1.00 94.67 ? 532 HOH A O 1 HETATM 6352 O O . HOH Y 9 . ? 45.201 -21.394 -61.335 1.00 15.42 ? 533 HOH A O 1 HETATM 6353 O O . HOH Y 9 . ? 43.819 -43.819 -38.239 0.25 25.37 ? 534 HOH A O 1 HETATM 6354 O O . HOH Y 9 . ? 37.443 -21.708 -61.743 1.00 15.67 ? 535 HOH A O 1 HETATM 6355 O O . HOH Y 9 . ? 10.327 -18.779 -52.310 1.00 20.70 ? 536 HOH A O 1 HETATM 6356 O O . HOH Y 9 . ? 22.120 -4.143 -60.301 1.00 39.45 ? 537 HOH A O 1 HETATM 6357 O O . HOH Y 9 . ? 35.623 -5.608 -61.036 1.00 18.55 ? 538 HOH A O 1 HETATM 6358 O O . HOH Y 9 . ? 25.349 -5.209 -51.240 1.00 30.25 ? 539 HOH A O 1 HETATM 6359 O O . HOH Y 9 . ? 24.465 -6.009 -48.509 1.00 31.45 ? 540 HOH A O 1 HETATM 6360 O O . HOH Y 9 . ? 13.440 -4.992 -49.485 1.00 18.83 ? 541 HOH A O 1 HETATM 6361 O O . HOH Y 9 . ? 37.375 -46.992 -21.062 1.00 17.66 ? 542 HOH A O 1 HETATM 6362 O O . HOH Y 9 . ? 5.849 -4.668 -37.067 1.00 24.90 ? 543 HOH A O 1 HETATM 6363 O O . HOH Y 9 . ? 15.803 -34.885 -64.205 1.00 34.87 ? 544 HOH A O 1 HETATM 6364 O O . HOH Y 9 . ? 35.492 -21.344 -24.388 1.00 24.85 ? 545 HOH A O 1 HETATM 6365 O O . HOH Y 9 . ? 30.344 -32.398 -37.853 1.00 24.69 ? 546 HOH A O 1 HETATM 6366 O O . HOH Y 9 . ? 8.726 -20.746 -29.884 1.00 19.06 ? 547 HOH A O 1 HETATM 6367 O O . HOH Y 9 . ? 28.817 -4.261 -60.204 1.00 19.21 ? 548 HOH A O 1 HETATM 6368 O O . HOH Y 9 . ? 25.926 -2.992 -52.356 1.00 15.71 ? 549 HOH A O 1 HETATM 6369 O O . HOH Y 9 . ? 15.332 -34.462 -33.387 1.00 15.17 ? 550 HOH A O 1 HETATM 6370 O O . HOH Y 9 . ? 40.894 -46.531 -22.767 1.00 32.70 ? 551 HOH A O 1 HETATM 6371 O O . HOH Y 9 . ? 44.718 -16.570 -30.967 1.00 15.00 ? 552 HOH A O 1 HETATM 6372 O O . HOH Y 9 . ? 20.724 -39.192 -63.474 1.00 25.08 ? 553 HOH A O 1 HETATM 6373 O O . HOH Y 9 . ? 31.182 -44.028 -28.503 1.00 11.30 ? 554 HOH A O 1 HETATM 6374 O O . HOH Y 9 . ? 8.047 0.324 -45.136 1.00 38.02 ? 555 HOH A O 1 HETATM 6375 O O . HOH Y 9 . ? 9.352 -14.479 -49.984 1.00 19.66 ? 556 HOH A O 1 HETATM 6376 O O . HOH Y 9 . ? 33.227 -27.966 -17.639 1.00 39.30 ? 557 HOH A O 1 HETATM 6377 O O . HOH Y 9 . ? 26.516 -0.862 -50.534 1.00 30.00 ? 558 HOH A O 1 HETATM 6378 O O . HOH Y 9 . ? 11.891 -31.793 -64.523 1.00 36.34 ? 559 HOH A O 1 HETATM 6379 O O . HOH Y 9 . ? 38.645 -37.900 -46.173 1.00 12.74 ? 560 HOH A O 1 HETATM 6380 O O . HOH Y 9 . ? 25.546 -29.766 -62.023 1.00 34.96 ? 561 HOH A O 1 HETATM 6381 O O . HOH Y 9 . ? 19.650 -22.124 -39.738 1.00 13.77 ? 562 HOH A O 1 HETATM 6382 O O . HOH Y 9 . ? 16.008 -30.597 -24.361 1.00 30.64 ? 563 HOH A O 1 HETATM 6383 O O . HOH Y 9 . ? 48.739 -15.600 -58.142 1.00 28.38 ? 564 HOH A O 1 HETATM 6384 O O . HOH Y 9 . ? 28.075 -18.026 -30.861 1.00 25.93 ? 565 HOH A O 1 HETATM 6385 O O . HOH Y 9 . ? 8.631 -42.206 -52.374 1.00 21.16 ? 566 HOH A O 1 HETATM 6386 O O . HOH Y 9 . ? 24.592 -23.228 -50.955 1.00 16.19 ? 567 HOH A O 1 HETATM 6387 O O . HOH Y 9 . ? -0.063 -17.054 -46.508 1.00 20.09 ? 568 HOH A O 1 HETATM 6388 O O . HOH Y 9 . ? 15.739 -10.386 -31.971 1.00 40.78 ? 569 HOH A O 1 HETATM 6389 O O . HOH Y 9 . ? 23.474 1.303 -46.859 1.00 18.82 ? 570 HOH A O 1 HETATM 6390 O O . HOH Y 9 . ? 41.140 -43.330 -24.389 1.00 18.98 ? 571 HOH A O 1 HETATM 6391 O O . HOH Y 9 . ? 26.921 -30.630 -64.417 1.00 38.52 ? 572 HOH A O 1 HETATM 6392 O O . HOH Y 9 . ? 29.311 -13.585 -40.877 1.00 23.97 ? 573 HOH A O 1 HETATM 6393 O O . HOH Y 9 . ? 39.469 -43.464 -32.998 1.00 27.98 ? 574 HOH A O 1 HETATM 6394 O O . HOH Y 9 . ? 15.405 -6.098 -32.126 1.00 47.16 ? 575 HOH A O 1 HETATM 6395 O O . HOH Y 9 . ? 46.627 -40.027 -33.644 1.00 20.11 ? 576 HOH A O 1 HETATM 6396 O O . HOH Y 9 . ? 30.453 -15.660 -40.662 1.00 28.41 ? 577 HOH A O 1 HETATM 6397 O O . HOH Y 9 . ? 31.112 -29.260 -59.687 1.00 30.17 ? 578 HOH A O 1 HETATM 6398 O O . HOH Y 9 . ? 4.141 -19.071 -41.995 1.00 15.58 ? 579 HOH A O 1 HETATM 6399 O O . HOH Y 9 . ? 44.275 -18.455 -62.963 1.00 22.84 ? 580 HOH A O 1 HETATM 6400 O O . HOH Y 9 . ? 11.223 -0.605 -41.838 1.00 22.88 ? 581 HOH A O 1 HETATM 6401 O O . HOH Y 9 . ? 18.164 -4.439 -33.311 1.00 38.84 ? 582 HOH A O 1 HETATM 6402 O O . HOH Y 9 . ? 34.092 -44.181 -27.847 1.00 33.60 ? 583 HOH A O 1 HETATM 6403 O O . HOH Y 9 . ? 43.813 -43.814 -26.886 0.25 14.71 ? 584 HOH A O 1 HETATM 6404 O O . HOH Y 9 . ? 28.783 -3.551 -52.761 1.00 14.83 ? 585 HOH A O 1 HETATM 6405 O O . HOH Y 9 . ? 38.811 -36.745 -50.049 1.00 34.75 ? 586 HOH A O 1 HETATM 6406 O O . HOH Y 9 . ? 7.046 -39.371 -38.474 1.00 23.76 ? 587 HOH A O 1 HETATM 6407 O O . HOH Y 9 . ? 41.037 -12.492 -33.040 1.00 27.38 ? 588 HOH A O 1 HETATM 6408 O O . HOH Y 9 . ? 16.358 -35.270 -56.802 1.00 26.86 ? 589 HOH A O 1 HETATM 6409 O O . HOH Y 9 . ? 29.935 -25.123 -24.828 1.00 21.71 ? 590 HOH A O 1 HETATM 6410 O O . HOH Y 9 . ? 7.344 -6.693 -36.131 1.00 31.86 ? 591 HOH A O 1 HETATM 6411 O O . HOH Y 9 . ? 40.322 -28.414 -21.465 1.00 23.66 ? 592 HOH A O 1 HETATM 6412 O O . HOH Y 9 . ? 24.011 -31.672 -27.634 1.00 30.10 ? 593 HOH A O 1 HETATM 6413 O O . HOH Y 9 . ? 26.343 -27.116 -60.623 1.00 29.34 ? 594 HOH A O 1 HETATM 6414 O O . HOH Y 9 . ? 13.878 -2.810 -50.666 1.00 30.98 ? 595 HOH A O 1 HETATM 6415 O O . HOH Y 9 . ? 6.358 -17.541 -61.161 1.00 23.36 ? 596 HOH A O 1 HETATM 6416 O O . HOH Y 9 . ? 19.869 -28.560 -35.769 1.00 42.69 ? 597 HOH A O 1 HETATM 6417 O O . HOH Y 9 . ? 43.803 -43.804 -30.421 0.25 28.34 ? 598 HOH A O 1 HETATM 6418 O O . HOH Y 9 . ? 33.557 -33.355 -20.622 1.00 33.23 ? 599 HOH A O 1 HETATM 6419 O O . HOH Y 9 . ? 43.818 -43.818 -34.997 0.25 15.30 ? 600 HOH A O 1 HETATM 6420 O O . HOH Y 9 . ? 5.473 -9.958 -43.491 1.00 20.61 ? 601 HOH A O 1 HETATM 6421 O O . HOH Y 9 . ? 40.390 -43.366 -42.684 1.00 36.57 ? 602 HOH A O 1 HETATM 6422 O O . HOH Y 9 . ? 12.781 -32.478 -59.414 1.00 31.99 ? 603 HOH A O 1 HETATM 6423 O O . HOH Y 9 . ? 21.328 -14.278 -32.266 1.00 21.25 ? 604 HOH A O 1 HETATM 6424 O O . HOH Y 9 . ? 28.655 -25.810 -55.134 1.00 21.62 ? 605 HOH A O 1 HETATM 6425 O O . HOH Y 9 . ? 31.107 -6.016 -34.912 1.00 27.54 ? 606 HOH A O 1 HETATM 6426 O O . HOH Y 9 . ? 41.227 -17.934 -21.846 1.00 26.67 ? 607 HOH A O 1 HETATM 6427 O O . HOH Y 9 . ? 6.331 -7.272 -33.902 1.00 25.04 ? 608 HOH A O 1 HETATM 6428 O O . HOH Y 9 . ? 9.665 -30.436 -32.008 1.00 23.92 ? 609 HOH A O 1 HETATM 6429 O O . HOH Z 9 . ? 13.998 -2.473 -21.733 1.00 14.99 ? 8 HOH B O 1 HETATM 6430 O O . HOH Z 9 . ? 26.700 -22.398 -4.293 1.00 17.78 ? 9 HOH B O 1 HETATM 6431 O O . HOH Z 9 . ? 26.852 -25.010 -18.263 1.00 20.97 ? 10 HOH B O 1 HETATM 6432 O O . HOH Z 9 . ? 9.015 -15.273 -15.940 1.00 16.95 ? 13 HOH B O 1 HETATM 6433 O O . HOH Z 9 . ? 18.996 -22.820 -19.864 1.00 18.49 ? 14 HOH B O 1 HETATM 6434 O O . HOH Z 9 . ? 25.414 -1.135 -10.724 1.00 14.92 ? 17 HOH B O 1 HETATM 6435 O O . HOH Z 9 . ? 19.584 -11.791 15.152 1.00 20.19 ? 18 HOH B O 1 HETATM 6436 O O . HOH Z 9 . ? 6.788 -2.787 -20.259 1.00 16.12 ? 20 HOH B O 1 HETATM 6437 O O . HOH Z 9 . ? 7.181 -12.551 -5.161 1.00 13.02 ? 21 HOH B O 1 HETATM 6438 O O . HOH Z 9 . ? 2.956 -6.768 -21.272 1.00 8.60 ? 22 HOH B O 1 HETATM 6439 O O . HOH Z 9 . ? 31.961 -26.121 -7.021 1.00 18.18 ? 23 HOH B O 1 HETATM 6440 O O . HOH Z 9 . ? 40.292 -15.219 4.005 1.00 17.04 ? 26 HOH B O 1 HETATM 6441 O O . HOH Z 9 . ? 5.599 -13.296 -22.629 1.00 7.76 ? 28 HOH B O 1 HETATM 6442 O O . HOH Z 9 . ? 23.968 -27.923 -10.299 1.00 11.42 ? 31 HOH B O 1 HETATM 6443 O O . HOH Z 9 . ? 18.372 -2.057 -26.299 1.00 16.97 ? 32 HOH B O 1 HETATM 6444 O O . HOH Z 9 . ? 20.710 -15.914 -6.888 1.00 10.17 ? 33 HOH B O 1 HETATM 6445 O O . HOH Z 9 . ? 20.950 -9.505 -23.665 1.00 25.91 ? 34 HOH B O 1 HETATM 6446 O O . HOH Z 9 . ? 19.387 -20.476 8.591 1.00 13.40 ? 35 HOH B O 1 HETATM 6447 O O . HOH Z 9 . ? 1.790 -33.905 -14.694 1.00 32.34 ? 36 HOH B O 1 HETATM 6448 O O . HOH Z 9 . ? 24.209 4.783 -13.130 1.00 13.51 ? 37 HOH B O 1 HETATM 6449 O O . HOH Z 9 . ? 4.898 -30.983 -5.291 1.00 9.42 ? 39 HOH B O 1 HETATM 6450 O O . HOH Z 9 . ? 41.199 -29.149 -3.197 1.00 14.18 ? 40 HOH B O 1 HETATM 6451 O O . HOH Z 9 . ? 2.830 -10.292 -28.075 1.00 15.72 ? 41 HOH B O 1 HETATM 6452 O O . HOH Z 9 . ? 28.222 -28.471 11.803 1.00 32.56 ? 45 HOH B O 1 HETATM 6453 O O . HOH Z 9 . ? 14.902 -16.251 5.931 1.00 17.16 ? 46 HOH B O 1 HETATM 6454 O O . HOH Z 9 . ? 30.825 -33.605 -3.693 1.00 18.43 ? 48 HOH B O 1 HETATM 6455 O O . HOH Z 9 . ? 7.908 -3.577 -2.713 1.00 23.98 ? 49 HOH B O 1 HETATM 6456 O O . HOH Z 9 . ? 28.863 -31.101 -3.807 1.00 22.28 ? 52 HOH B O 1 HETATM 6457 O O . HOH Z 9 . ? 27.094 -23.734 -15.509 1.00 14.81 ? 53 HOH B O 1 HETATM 6458 O O . HOH Z 9 . ? 21.437 -11.178 -6.016 1.00 18.85 ? 54 HOH B O 1 HETATM 6459 O O . HOH Z 9 . ? 15.489 2.576 -0.842 1.00 26.70 ? 56 HOH B O 1 HETATM 6460 O O . HOH Z 9 . ? 27.715 -37.446 1.682 1.00 27.59 ? 58 HOH B O 1 HETATM 6461 O O . HOH Z 9 . ? 1.575 -0.220 -9.326 1.00 75.46 ? 59 HOH B O 1 HETATM 6462 O O . HOH Z 9 . ? 15.323 -3.433 -27.229 1.00 28.62 ? 60 HOH B O 1 HETATM 6463 O O . HOH Z 9 . ? 8.498 1.436 -7.881 1.00 15.06 ? 66 HOH B O 1 HETATM 6464 O O . HOH Z 9 . ? 23.358 -11.475 -14.159 1.00 26.03 ? 67 HOH B O 1 HETATM 6465 O O . HOH Z 9 . ? 37.074 -5.420 -7.023 1.00 10.18 ? 473 HOH B O 1 HETATM 6466 O O . HOH Z 9 . ? 18.528 -13.923 -23.699 1.00 24.05 ? 474 HOH B O 1 HETATM 6467 O O . HOH Z 9 . ? 25.573 -11.562 -9.997 1.00 31.84 ? 475 HOH B O 1 HETATM 6468 O O . HOH Z 9 . ? 7.343 -23.264 -19.839 1.00 18.89 ? 476 HOH B O 1 HETATM 6469 O O . HOH Z 9 . ? 16.793 -17.622 6.101 1.00 18.62 ? 477 HOH B O 1 HETATM 6470 O O . HOH Z 9 . ? 30.493 -14.586 -4.304 1.00 20.12 ? 478 HOH B O 1 HETATM 6471 O O . HOH Z 9 . ? 18.230 -16.987 0.275 1.00 13.26 ? 479 HOH B O 1 HETATM 6472 O O . HOH Z 9 . ? 30.992 -15.489 -11.796 1.00 35.22 ? 480 HOH B O 1 HETATM 6473 O O . HOH Z 9 . ? 37.554 -28.311 -16.936 1.00 34.37 ? 481 HOH B O 1 HETATM 6474 O O . HOH Z 9 . ? 38.782 -30.060 0.826 1.00 18.10 ? 482 HOH B O 1 HETATM 6475 O O . HOH Z 9 . ? 41.050 -17.567 3.849 1.00 15.78 ? 483 HOH B O 1 HETATM 6476 O O . HOH Z 9 . ? 7.583 -13.020 -24.405 1.00 12.57 ? 484 HOH B O 1 HETATM 6477 O O . HOH Z 9 . ? 26.446 1.135 -9.629 1.00 17.90 ? 485 HOH B O 1 HETATM 6478 O O . HOH Z 9 . ? 20.420 -27.915 15.366 1.00 34.12 ? 486 HOH B O 1 HETATM 6479 O O . HOH Z 9 . ? 7.308 -8.413 -25.740 1.00 19.32 ? 487 HOH B O 1 HETATM 6480 O O . HOH Z 9 . ? 38.929 -29.199 -13.325 1.00 33.33 ? 488 HOH B O 1 HETATM 6481 O O . HOH Z 9 . ? 20.199 -2.469 -20.316 1.00 19.25 ? 489 HOH B O 1 HETATM 6482 O O . HOH Z 9 . ? 35.207 -1.904 -14.646 1.00 24.02 ? 490 HOH B O 1 HETATM 6483 O O . HOH Z 9 . ? 10.414 -21.891 -19.619 1.00 22.57 ? 491 HOH B O 1 HETATM 6484 O O . HOH Z 9 . ? -0.155 -12.789 -19.773 1.00 11.80 ? 492 HOH B O 1 HETATM 6485 O O . HOH Z 9 . ? 37.592 -23.350 -1.378 1.00 19.39 ? 493 HOH B O 1 HETATM 6486 O O . HOH Z 9 . ? 23.688 -34.594 6.242 1.00 15.88 ? 494 HOH B O 1 HETATM 6487 O O . HOH Z 9 . ? 29.453 -10.761 -11.192 1.00 21.19 ? 495 HOH B O 1 HETATM 6488 O O . HOH Z 9 . ? 13.265 -34.285 -16.550 1.00 34.13 ? 496 HOH B O 1 HETATM 6489 O O . HOH Z 9 . ? 22.981 -5.737 10.761 1.00 19.12 ? 497 HOH B O 1 HETATM 6490 O O . HOH Z 9 . ? 35.626 -31.496 -10.922 1.00 15.06 ? 498 HOH B O 1 HETATM 6491 O O . HOH Z 9 . ? 29.264 -34.467 1.438 1.00 33.21 ? 499 HOH B O 1 HETATM 6492 O O . HOH Z 9 . ? 30.975 -10.417 4.086 1.00 48.63 ? 500 HOH B O 1 HETATM 6493 O O . HOH Z 9 . ? 11.262 -13.433 -10.966 1.00 20.16 ? 501 HOH B O 1 HETATM 6494 O O . HOH Z 9 . ? 18.610 2.390 10.350 1.00 19.23 ? 502 HOH B O 1 HETATM 6495 O O . HOH Z 9 . ? 5.839 -5.119 -2.437 1.00 19.71 ? 503 HOH B O 1 HETATM 6496 O O . HOH Z 9 . ? 14.483 -25.004 8.989 1.00 25.46 ? 504 HOH B O 1 HETATM 6497 O O . HOH Z 9 . ? 28.293 -13.461 -7.861 1.00 21.60 ? 505 HOH B O 1 HETATM 6498 O O . HOH Z 9 . ? 1.446 -34.951 4.602 1.00 16.26 ? 506 HOH B O 1 HETATM 6499 O O . HOH Z 9 . ? 25.720 -39.077 -12.726 1.00 14.74 ? 507 HOH B O 1 HETATM 6500 O O . HOH Z 9 . ? 24.887 -15.613 -26.506 1.00 23.08 ? 508 HOH B O 1 HETATM 6501 O O . HOH Z 9 . ? 26.990 -35.246 3.049 1.00 26.01 ? 509 HOH B O 1 HETATM 6502 O O . HOH Z 9 . ? 25.164 -8.481 -22.781 1.00 33.49 ? 510 HOH B O 1 HETATM 6503 O O . HOH Z 9 . ? 9.582 -9.137 8.748 1.00 31.10 ? 511 HOH B O 1 HETATM 6504 O O . HOH Z 9 . ? 29.644 -19.805 -15.806 1.00 20.58 ? 512 HOH B O 1 HETATM 6505 O O . HOH Z 9 . ? 19.832 -22.191 3.901 1.00 30.10 ? 513 HOH B O 1 HETATM 6506 O O . HOH Z 9 . ? 3.251 -2.672 -25.346 1.00 21.54 ? 514 HOH B O 1 HETATM 6507 O O . HOH Z 9 . ? 21.653 -24.117 -8.882 1.00 9.43 ? 515 HOH B O 1 HETATM 6508 O O . HOH Z 9 . ? 9.442 -28.576 -15.590 1.00 11.28 ? 516 HOH B O 1 HETATM 6509 O O . HOH Z 9 . ? 34.306 -37.939 -3.045 1.00 18.50 ? 517 HOH B O 1 HETATM 6510 O O . HOH Z 9 . ? 30.350 -14.710 -6.985 1.00 22.27 ? 518 HOH B O 1 HETATM 6511 O O . HOH Z 9 . ? 11.793 -19.808 -21.207 1.00 16.49 ? 519 HOH B O 1 HETATM 6512 O O . HOH Z 9 . ? 43.002 -24.536 -1.488 1.00 22.64 ? 520 HOH B O 1 HETATM 6513 O O . HOH Z 9 . ? 22.453 -17.624 1.925 1.00 11.27 ? 521 HOH B O 1 HETATM 6514 O O . HOH Z 9 . ? 20.946 -13.994 -29.359 1.00 16.25 ? 522 HOH B O 1 HETATM 6515 O O . HOH Z 9 . ? 25.093 -15.916 5.673 1.00 24.85 ? 523 HOH B O 1 HETATM 6516 O O . HOH Z 9 . ? 27.179 1.088 -17.663 1.00 27.61 ? 524 HOH B O 1 HETATM 6517 O O . HOH Z 9 . ? 23.340 -14.297 -17.496 1.00 12.64 ? 525 HOH B O 1 HETATM 6518 O O . HOH Z 9 . ? 41.774 -14.148 -3.750 1.00 22.24 ? 526 HOH B O 1 HETATM 6519 O O . HOH Z 9 . ? 22.135 -6.402 13.267 1.00 20.47 ? 527 HOH B O 1 HETATM 6520 O O . HOH Z 9 . ? 26.801 -36.052 -11.968 1.00 16.55 ? 528 HOH B O 1 HETATM 6521 O O . HOH Z 9 . ? 32.762 -41.944 3.190 1.00 16.25 ? 529 HOH B O 1 HETATM 6522 O O . HOH Z 9 . ? 20.653 -1.111 -23.541 1.00 15.30 ? 530 HOH B O 1 HETATM 6523 O O . HOH Z 9 . ? 10.059 -4.804 -1.161 1.00 29.14 ? 531 HOH B O 1 HETATM 6524 O O . HOH Z 9 . ? 38.384 -18.446 2.441 1.00 16.42 ? 532 HOH B O 1 HETATM 6525 O O . HOH Z 9 . ? 37.818 -19.220 0.081 1.00 25.11 ? 533 HOH B O 1 HETATM 6526 O O . HOH Z 9 . ? 37.296 -37.864 -4.805 1.00 29.84 ? 534 HOH B O 1 HETATM 6527 O O . HOH Z 9 . ? 22.944 -35.053 -18.744 1.00 21.57 ? 535 HOH B O 1 HETATM 6528 O O . HOH Z 9 . ? 19.173 -7.218 9.826 1.00 21.36 ? 536 HOH B O 1 HETATM 6529 O O . HOH Z 9 . ? 33.361 -38.786 -5.240 1.00 29.04 ? 537 HOH B O 1 HETATM 6530 O O . HOH Z 9 . ? 12.624 4.154 1.401 1.00 29.38 ? 538 HOH B O 1 HETATM 6531 O O . HOH Z 9 . ? 13.244 -24.412 18.740 1.00 24.06 ? 539 HOH B O 1 HETATM 6532 O O . HOH Z 9 . ? 24.954 -39.533 -6.870 1.00 17.41 ? 540 HOH B O 1 HETATM 6533 O O . HOH Z 9 . ? 24.787 -33.826 3.400 1.00 17.71 ? 541 HOH B O 1 HETATM 6534 O O . HOH Z 9 . ? 23.822 -27.081 -4.059 1.00 20.02 ? 542 HOH B O 1 HETATM 6535 O O . HOH Z 9 . ? 19.549 -23.397 6.721 1.00 19.34 ? 543 HOH B O 1 HETATM 6536 O O . HOH Z 9 . ? 14.846 -12.628 10.966 1.00 41.99 ? 544 HOH B O 1 HETATM 6537 O O . HOH Z 9 . ? 16.423 -12.564 7.088 1.00 23.01 ? 545 HOH B O 1 HETATM 6538 O O . HOH Z 9 . ? -0.003 -0.000 -21.071 0.25 52.18 ? 546 HOH B O 1 HETATM 6539 O O . HOH Z 9 . ? 0.310 -4.226 -15.786 1.00 11.85 ? 547 HOH B O 1 HETATM 6540 O O . HOH Z 9 . ? 11.388 -31.091 10.772 1.00 15.42 ? 548 HOH B O 1 HETATM 6541 O O . HOH Z 9 . ? 0.532 -2.851 -6.408 1.00 30.37 ? 549 HOH B O 1 HETATM 6542 O O . HOH Z 9 . ? 38.812 -18.583 10.820 1.00 19.70 ? 550 HOH B O 1 HETATM 6543 O O . HOH Z 9 . ? 10.278 -10.453 -27.448 1.00 27.73 ? 551 HOH B O 1 HETATM 6544 O O . HOH Z 9 . ? 43.140 -13.825 -6.081 1.00 22.30 ? 552 HOH B O 1 HETATM 6545 O O . HOH Z 9 . ? 30.657 -0.486 -16.246 1.00 20.42 ? 553 HOH B O 1 HETATM 6546 O O . HOH Z 9 . ? 9.397 -9.470 -30.328 1.00 30.02 ? 554 HOH B O 1 HETATM 6547 O O . HOH Z 9 . ? 15.453 -23.818 -12.565 1.00 36.27 ? 555 HOH B O 1 HETATM 6548 O O . HOH Z 9 . ? -0.223 -7.633 -18.972 1.00 15.49 ? 556 HOH B O 1 HETATM 6549 O O . HOH Z 9 . ? 16.040 -36.568 17.192 1.00 52.35 ? 557 HOH B O 1 HETATM 6550 O O . HOH Z 9 . ? 23.616 -39.880 6.508 1.00 29.77 ? 558 HOH B O 1 HETATM 6551 O O . HOH Z 9 . ? 26.521 -42.373 4.682 1.00 25.07 ? 559 HOH B O 1 HETATM 6552 O O . HOH Z 9 . ? 31.575 -2.782 -15.577 1.00 23.04 ? 560 HOH B O 1 HETATM 6553 O O . HOH Z 9 . ? 18.381 -2.614 16.290 1.00 45.91 ? 561 HOH B O 1 HETATM 6554 O O . HOH Z 9 . ? 29.866 -8.290 -16.879 1.00 27.62 ? 562 HOH B O 1 HETATM 6555 O O . HOH Z 9 . ? 16.506 2.983 9.142 1.00 28.89 ? 563 HOH B O 1 HETATM 6556 O O . HOH Z 9 . ? 11.226 -10.387 16.310 1.00 33.67 ? 564 HOH B O 1 HETATM 6557 O O . HOH Z 9 . ? 37.683 -12.538 -13.307 1.00 35.74 ? 565 HOH B O 1 HETATM 6558 O O . HOH Z 9 . ? 29.546 -22.259 -16.373 1.00 28.59 ? 566 HOH B O 1 HETATM 6559 O O . HOH Z 9 . ? 21.640 -10.442 -16.498 1.00 25.60 ? 567 HOH B O 1 HETATM 6560 O O . HOH Z 9 . ? 4.605 -37.100 -9.406 1.00 25.25 ? 568 HOH B O 1 HETATM 6561 O O . HOH Z 9 . ? 4.092 -33.607 1.760 1.00 9.32 ? 569 HOH B O 1 HETATM 6562 O O . HOH Z 9 . ? 18.987 -10.387 -16.127 1.00 21.25 ? 570 HOH B O 1 HETATM 6563 O O . HOH Z 9 . ? 3.729 2.778 -14.946 1.00 16.78 ? 571 HOH B O 1 HETATM 6564 O O . HOH Z 9 . ? 36.711 -36.319 -12.918 1.00 24.35 ? 572 HOH B O 1 HETATM 6565 O O . HOH Z 9 . ? 4.406 -23.140 14.838 1.00 12.70 ? 573 HOH B O 1 HETATM 6566 O O . HOH Z 9 . ? 9.022 -27.603 8.129 1.00 48.40 ? 574 HOH B O 1 HETATM 6567 O O . HOH Z 9 . ? 4.765 -1.156 -13.540 1.00 38.08 ? 575 HOH B O 1 HETATM 6568 O O . HOH Z 9 . ? 4.600 -34.181 8.417 1.00 15.00 ? 576 HOH B O 1 HETATM 6569 O O . HOH Z 9 . ? 41.034 -29.832 2.597 1.00 23.36 ? 577 HOH B O 1 HETATM 6570 O O . HOH Z 9 . ? 7.326 -30.823 -17.208 1.00 27.07 ? 578 HOH B O 1 HETATM 6571 O O . HOH Z 9 . ? 23.456 -24.972 19.252 1.00 27.38 ? 579 HOH B O 1 HETATM 6572 O O . HOH Z 9 . ? 15.665 -20.464 -21.191 1.00 27.61 ? 580 HOH B O 1 HETATM 6573 O O . HOH Z 9 . ? 9.343 -18.896 19.258 1.00 24.07 ? 581 HOH B O 1 HETATM 6574 O O . HOH Z 9 . ? 4.836 -4.499 -4.687 1.00 17.35 ? 582 HOH B O 1 HETATM 6575 O O . HOH Z 9 . ? 13.362 -28.118 -23.945 1.00 23.43 ? 583 HOH B O 1 HETATM 6576 O O . HOH Z 9 . ? 32.027 -3.197 -12.967 1.00 16.26 ? 584 HOH B O 1 HETATM 6577 O O . HOH Z 9 . ? 25.685 0.450 14.336 1.00 23.21 ? 585 HOH B O 1 HETATM 6578 O O . HOH Z 9 . ? 19.801 -34.195 -10.598 1.00 23.76 ? 586 HOH B O 1 # loop_ _pdbx_poly_seq_scheme.asym_id _pdbx_poly_seq_scheme.entity_id _pdbx_poly_seq_scheme.seq_id _pdbx_poly_seq_scheme.mon_id _pdbx_poly_seq_scheme.ndb_seq_num _pdbx_poly_seq_scheme.pdb_seq_num _pdbx_poly_seq_scheme.auth_seq_num _pdbx_poly_seq_scheme.pdb_mon_id _pdbx_poly_seq_scheme.auth_mon_id _pdbx_poly_seq_scheme.pdb_strand_id _pdbx_poly_seq_scheme.pdb_ins_code _pdbx_poly_seq_scheme.hetero A 1 1 GLY 1 70 ? ? ? A . n A 1 2 VAL 2 71 ? ? ? A . n A 1 3 THR 3 72 ? ? ? A . n A 1 4 LEU 4 73 ? ? ? A . n A 1 5 LEU 5 74 ? ? ? A . n A 1 6 LEU 6 75 ? ? ? A . n A 1 7 PRO 7 76 ? ? ? A . n A 1 8 GLU 8 77 ? ? ? A . n A 1 9 PRO 9 78 78 PRO PRO A . n A 1 10 GLU 10 79 79 GLU GLU A . n A 1 11 TRP 11 80 80 TRP TRP A . n A 1 12 THR 12 81 81 THR THR A . n A 1 13 TYR 13 82 82 TYR TYR A . n A 1 14 PRO 14 83 83 PRO PRO A . n A 1 15 ARG 15 84 84 ARG ARG A . n A 1 16 LEU 16 85 85 LEU LEU A . n A 1 17 SER 17 86 86 SER SER A . n A 1 18 CYS 18 87 87 CYS CYS A . n A 1 19 PRO 19 88 88 PRO PRO A . n A 1 20 GLY 20 89 89 GLY GLY A . n A 1 21 SER 21 90 90 SER SER A . n A 1 22 THR 22 91 91 THR THR A . n A 1 23 PHE 23 92 92 PHE PHE A . n A 1 24 GLN 24 93 93 GLN GLN A . n A 1 25 LYS 25 94 94 LYS LYS A . n A 1 26 ALA 26 95 95 ALA ALA A . n A 1 27 LEU 27 96 96 LEU LEU A . n A 1 28 LEU 28 97 97 LEU LEU A . n A 1 29 ILE 29 98 98 ILE ILE A . n A 1 30 SER 30 99 99 SER SER A . n A 1 31 PRO 31 100 100 PRO PRO A . n A 1 32 HIS 32 101 101 HIS HIS A . n A 1 33 ARG 33 102 102 ARG ARG A . n A 1 34 PHE 34 103 103 PHE PHE A . n A 1 35 GLY 35 104 104 GLY GLY A . n A 1 36 GLU 36 105 105 GLU GLU A . n A 1 37 THR 37 106 106 THR THR A . n A 1 38 LYS 38 107 107 LYS LYS A . n A 1 39 GLY 39 108 108 GLY GLY A . n A 1 40 ASN 40 109 109 ASN ASN A . n A 1 41 SER 41 110 110 SER SER A . n A 1 42 ALA 42 111 111 ALA ALA A . n A 1 43 PRO 43 112 112 PRO PRO A . n A 1 44 LEU 44 113 113 LEU LEU A . n A 1 45 ILE 45 114 114 ILE ILE A . n A 1 46 ILE 46 115 115 ILE ILE A . n A 1 47 ARG 47 116 116 ARG ARG A . n A 1 48 GLU 48 117 117 GLU GLU A . n A 1 49 PRO 49 118 118 PRO PRO A . n A 1 50 PHE 50 119 119 PHE PHE A . n A 1 51 ILE 51 120 120 ILE ILE A . n A 1 52 ALA 52 121 121 ALA ALA A . n A 1 53 CYS 53 122 122 CYS CYS A . n A 1 54 GLY 54 123 123 GLY GLY A . n A 1 55 PRO 55 124 124 PRO PRO A . n A 1 56 LYS 56 125 125 LYS LYS A . n A 1 57 GLU 57 126 126 GLU GLU A . n A 1 58 CYS 58 127 127 CYS CYS A . n A 1 59 LYS 59 128 128 LYS LYS A . n A 1 60 HIS 60 129 129 HIS HIS A . n A 1 61 PHE 61 130 130 PHE PHE A . n A 1 62 ALA 62 131 131 ALA ALA A . n A 1 63 LEU 63 132 132 LEU LEU A . n A 1 64 THR 64 133 133 THR THR A . n A 1 65 HIS 65 134 134 HIS HIS A . n A 1 66 TYR 66 135 135 TYR TYR A . n A 1 67 ALA 67 136 136 ALA ALA A . n A 1 68 ALA 68 137 137 ALA ALA A . n A 1 69 GLN 69 138 138 GLN GLN A . n A 1 70 PRO 70 139 139 PRO PRO A . n A 1 71 GLY 71 140 140 GLY GLY A . n A 1 72 GLY 72 141 141 GLY GLY A . n A 1 73 TYR 73 142 142 TYR TYR A . n A 1 74 TYR 74 143 143 TYR TYR A . n A 1 75 ASN 75 144 144 ASN ASN A . n A 1 76 GLY 76 145 145 GLY GLY A . n A 1 77 THR 77 146 146 THR THR A . n A 1 78 ARG 78 147 147 ARG ARG A . n A 1 79 GLY 79 148 148 GLY GLY A . n A 1 80 ASP 80 149 149 ASP ASP A . n A 1 81 ARG 81 150 150 ARG ARG A . n A 1 82 ASN 82 151 151 ASN ASN A . n A 1 83 LYS 83 152 152 LYS LYS A . n A 1 84 LEU 84 153 153 LEU LEU A . n A 1 85 ARG 85 154 154 ARG ARG A . n A 1 86 HIS 86 155 155 HIS HIS A . n A 1 87 LEU 87 156 156 LEU LEU A . n A 1 88 ILE 88 157 157 ILE ILE A . n A 1 89 SER 89 158 158 SER SER A . n A 1 90 VAL 90 159 159 VAL VAL A . n A 1 91 LYS 91 160 160 LYS LYS A . n A 1 92 LEU 92 161 161 LEU LEU A . n A 1 93 GLY 93 162 162 GLY GLY A . n A 1 94 LYS 94 163 163 LYS LYS A . n A 1 95 ILE 95 164 164 ILE ILE A . n A 1 96 PRO 96 165 165 PRO PRO A . n A 1 97 THR 97 166 166 THR THR A . n A 1 98 VAL 98 167 167 VAL VAL A . n A 1 99 GLU 99 168 168 GLU GLU A . n A 1 100 ASN 100 169 169 ASN ASN A . n A 1 101 SER 101 170 170 SER SER A . n A 1 102 ILE 102 171 171 ILE ILE A . n A 1 103 PHE 103 172 172 PHE PHE A . n A 1 104 HIS 104 173 173 HIS HIS A . n A 1 105 MET 105 174 174 MET MET A . n A 1 106 ALA 106 175 175 ALA ALA A . n A 1 107 ALA 107 176 176 ALA ALA A . n A 1 108 TRP 108 177 177 TRP TRP A . n A 1 109 SER 109 178 178 SER SER A . n A 1 110 GLY 110 179 179 GLY GLY A . n A 1 111 SER 111 180 180 SER SER A . n A 1 112 ALA 112 181 181 ALA ALA A . n A 1 113 CYS 113 182 182 CYS CYS A . n A 1 114 HIS 114 183 183 HIS HIS A . n A 1 115 ASP 115 184 184 ASP ASP A . n A 1 116 GLY 116 185 185 GLY GLY A . n A 1 117 LYS 117 186 186 LYS LYS A . n A 1 118 GLU 118 187 187 GLU GLU A . n A 1 119 TRP 119 188 188 TRP TRP A . n A 1 120 THR 120 189 189 THR THR A . n A 1 121 TYR 121 190 190 TYR TYR A . n A 1 122 ILE 122 191 191 ILE ILE A . n A 1 123 GLY 123 192 192 GLY GLY A . n A 1 124 VAL 124 193 193 VAL VAL A . n A 1 125 ASP 125 194 194 ASP ASP A . n A 1 126 GLY 126 195 195 GLY GLY A . n A 1 127 PRO 127 196 196 PRO PRO A . n A 1 128 ASP 128 197 197 ASP ASP A . n A 1 129 ASN 129 198 198 ASN ASN A . n A 1 130 ASN 130 199 199 ASN ASN A . n A 1 131 ALA 131 200 200 ALA ALA A . n A 1 132 LEU 132 201 201 LEU LEU A . n A 1 133 LEU 133 202 202 LEU LEU A . n A 1 134 LYS 134 203 203 LYS LYS A . n A 1 135 ILE 135 204 204 ILE ILE A . n A 1 136 LYS 136 205 205 LYS LYS A . n A 1 137 TYR 137 206 206 TYR TYR A . n A 1 138 GLY 138 207 207 GLY GLY A . n A 1 139 GLU 139 208 208 GLU GLU A . n A 1 140 ALA 140 209 209 ALA ALA A . n A 1 141 TYR 141 210 210 TYR TYR A . n A 1 142 THR 142 211 211 THR THR A . n A 1 143 ASP 143 212 212 ASP ASP A . n A 1 144 THR 144 213 213 THR THR A . n A 1 145 TYR 145 214 214 TYR TYR A . n A 1 146 HIS 146 215 215 HIS HIS A . n A 1 147 SER 147 216 216 SER SER A . n A 1 148 TYR 148 217 217 TYR TYR A . n A 1 149 ALA 149 218 218 ALA ALA A . n A 1 150 ASN 150 219 219 ASN ASN A . n A 1 151 ASN 151 220 220 ASN ASN A . n A 1 152 ILE 152 221 221 ILE ILE A . n A 1 153 LEU 153 222 222 LEU LEU A . n A 1 154 ARG 154 223 223 ARG ARG A . n A 1 155 THR 155 224 224 THR THR A . n A 1 156 GLN 156 225 225 GLN GLN A . n A 1 157 GLU 157 226 226 GLU GLU A . n A 1 158 SER 158 227 227 SER SER A . n A 1 159 ALA 159 228 228 ALA ALA A . n A 1 160 CYS 160 229 229 CYS CYS A . n A 1 161 ASN 161 230 230 ASN ASN A . n A 1 162 CYS 162 231 231 CYS CYS A . n A 1 163 ILE 163 232 232 ILE ILE A . n A 1 164 GLY 164 233 233 GLY GLY A . n A 1 165 GLY 165 234 234 GLY GLY A . n A 1 166 ASN 166 235 235 ASN ASN A . n A 1 167 CYS 167 236 236 CYS CYS A . n A 1 168 TYR 168 237 237 TYR TYR A . n A 1 169 LEU 169 238 238 LEU LEU A . n A 1 170 MET 170 239 239 MET MET A . n A 1 171 ILE 171 240 240 ILE ILE A . n A 1 172 THR 172 241 241 THR THR A . n A 1 173 ASP 173 242 242 ASP ASP A . n A 1 174 GLY 174 243 243 GLY GLY A . n A 1 175 SER 175 244 244 SER SER A . n A 1 176 ALA 176 245 245 ALA ALA A . n A 1 177 SER 177 246 246 SER SER A . n A 1 178 GLY 178 247 247 GLY GLY A . n A 1 179 ILE 179 248 248 ILE ILE A . n A 1 180 SER 180 249 249 SER SER A . n A 1 181 GLU 181 250 250 GLU GLU A . n A 1 182 CYS 182 251 251 CYS CYS A . n A 1 183 ARG 183 252 252 ARG ARG A . n A 1 184 PHE 184 253 253 PHE PHE A . n A 1 185 LEU 185 254 254 LEU LEU A . n A 1 186 LYS 186 255 255 LYS LYS A . n A 1 187 ILE 187 256 256 ILE ILE A . n A 1 188 ARG 188 257 257 ARG ARG A . n A 1 189 GLU 189 258 258 GLU GLU A . n A 1 190 GLY 190 259 259 GLY GLY A . n A 1 191 ARG 191 260 260 ARG ARG A . n A 1 192 ILE 192 261 261 ILE ILE A . n A 1 193 ILE 193 262 262 ILE ILE A . n A 1 194 LYS 194 263 263 LYS LYS A . n A 1 195 GLU 195 264 264 GLU GLU A . n A 1 196 ILE 196 265 265 ILE ILE A . n A 1 197 PHE 197 266 266 PHE PHE A . n A 1 198 PRO 198 267 267 PRO PRO A . n A 1 199 THR 199 268 268 THR THR A . n A 1 200 GLY 200 269 269 GLY GLY A . n A 1 201 ARG 201 270 270 ARG ARG A . n A 1 202 VAL 202 271 271 VAL VAL A . n A 1 203 LYS 203 272 272 LYS LYS A . n A 1 204 HIS 204 273 273 HIS HIS A . n A 1 205 THR 205 274 274 THR THR A . n A 1 206 GLU 206 275 275 GLU GLU A . n A 1 207 GLU 207 276 276 GLU GLU A . n A 1 208 CYS 208 277 277 CYS CYS A . n A 1 209 THR 209 278 278 THR THR A . n A 1 210 CYS 210 279 279 CYS CYS A . n A 1 211 GLY 211 280 280 GLY GLY A . n A 1 212 PHE 212 281 281 PHE PHE A . n A 1 213 ALA 213 282 282 ALA ALA A . n A 1 214 SER 214 283 283 SER SER A . n A 1 215 ASN 215 284 284 ASN ASN A . n A 1 216 LYS 216 285 285 LYS LYS A . n A 1 217 THR 217 286 286 THR THR A . n A 1 218 ILE 218 287 287 ILE ILE A . n A 1 219 GLU 219 288 288 GLU GLU A . n A 1 220 CYS 220 289 289 CYS CYS A . n A 1 221 ALA 221 290 290 ALA ALA A . n A 1 222 CYS 222 291 291 CYS CYS A . n A 1 223 ARG 223 292 292 ARG ARG A . n A 1 224 ASP 224 293 293 ASP ASP A . n A 1 225 ASN 225 294 294 ASN ASN A . n A 1 226 SER 226 295 295 SER SER A . n A 1 227 TYR 227 296 296 TYR TYR A . n A 1 228 THR 228 297 297 THR THR A . n A 1 229 ALA 229 298 298 ALA ALA A . n A 1 230 LYS 230 299 299 LYS LYS A . n A 1 231 ARG 231 300 300 ARG ARG A . n A 1 232 PRO 232 301 301 PRO PRO A . n A 1 233 PHE 233 302 302 PHE PHE A . n A 1 234 VAL 234 303 303 VAL VAL A . n A 1 235 LYS 235 304 304 LYS LYS A . n A 1 236 LEU 236 305 305 LEU LEU A . n A 1 237 ASN 237 306 306 ASN ASN A . n A 1 238 VAL 238 307 307 VAL VAL A . n A 1 239 GLU 239 308 308 GLU GLU A . n A 1 240 THR 240 309 309 THR THR A . n A 1 241 ASP 241 310 310 ASP ASP A . n A 1 242 THR 242 311 311 THR THR A . n A 1 243 ALA 243 312 312 ALA ALA A . n A 1 244 GLU 244 313 313 GLU GLU A . n A 1 245 ILE 245 314 314 ILE ILE A . n A 1 246 ARG 246 315 315 ARG ARG A . n A 1 247 LEU 247 316 316 LEU LEU A . n A 1 248 MET 248 317 317 MET MET A . n A 1 249 CYS 249 318 318 CYS CYS A . n A 1 250 THR 250 319 319 THR THR A . n A 1 251 GLU 251 320 320 GLU GLU A . n A 1 252 THR 252 321 321 THR THR A . n A 1 253 TYR 253 322 322 TYR TYR A . n A 1 254 LEU 254 323 323 LEU LEU A . n A 1 255 ASP 255 324 324 ASP ASP A . n A 1 256 THR 256 325 325 THR THR A . n A 1 257 PRO 257 326 326 PRO PRO A . n A 1 258 ARG 258 327 327 ARG ARG A . n A 1 259 PRO 259 328 328 PRO PRO A . n A 1 260 ASP 260 329 329 ASP ASP A . n A 1 261 ASP 261 330 330 ASP ASP A . n A 1 262 GLY 262 331 331 GLY GLY A . n A 1 263 SER 263 332 332 SER SER A . n A 1 264 ILE 264 333 333 ILE ILE A . n A 1 265 THR 265 334 334 THR THR A . n A 1 266 GLY 266 335 335 GLY GLY A . n A 1 267 PRO 267 336 336 PRO PRO A . n A 1 268 CYS 268 337 337 CYS CYS A . n A 1 269 GLU 269 338 338 GLU GLU A . n A 1 270 SER 270 339 339 SER SER A . n A 1 271 ASN 271 340 340 ASN ASN A . n A 1 272 GLY 272 341 341 GLY GLY A . n A 1 273 ASP 273 342 342 ASP ASP A . n A 1 274 LYS 274 343 343 LYS LYS A . n A 1 275 GLY 275 344 344 GLY GLY A . n A 1 276 SER 276 345 345 SER SER A . n A 1 277 GLY 277 346 346 GLY GLY A . n A 1 278 GLY 278 347 347 GLY GLY A . n A 1 279 ILE 279 348 348 ILE ILE A . n A 1 280 LYS 280 349 349 LYS LYS A . n A 1 281 GLY 281 350 350 GLY GLY A . n A 1 282 GLY 282 351 351 GLY GLY A . n A 1 283 PHE 283 352 352 PHE PHE A . n A 1 284 VAL 284 353 353 VAL VAL A . n A 1 285 HIS 285 354 354 HIS HIS A . n A 1 286 GLN 286 355 355 GLN GLN A . n A 1 287 ARG 287 356 356 ARG ARG A . n A 1 288 MET 288 357 357 MET MET A . n A 1 289 ALA 289 358 358 ALA ALA A . n A 1 290 SER 290 359 359 SER SER A . n A 1 291 LYS 291 360 360 LYS LYS A . n A 1 292 ILE 292 361 361 ILE ILE A . n A 1 293 GLY 293 362 362 GLY GLY A . n A 1 294 ARG 294 363 363 ARG ARG A . n A 1 295 TRP 295 364 364 TRP TRP A . n A 1 296 TYR 296 365 365 TYR TYR A . n A 1 297 SER 297 366 366 SER SER A . n A 1 298 ARG 298 367 367 ARG ARG A . n A 1 299 THR 299 368 368 THR THR A . n A 1 300 MET 300 369 369 MET MET A . n A 1 301 SER 301 370 370 SER SER A . n A 1 302 LYS 302 371 371 LYS LYS A . n A 1 303 THR 303 372 372 THR THR A . n A 1 304 LYS 304 373 373 LYS LYS A . n A 1 305 ARG 305 374 374 ARG ARG A . n A 1 306 MET 306 375 375 MET MET A . n A 1 307 GLY 307 376 376 GLY GLY A . n A 1 308 MET 308 377 377 MET MET A . n A 1 309 GLY 309 378 378 GLY GLY A . n A 1 310 LEU 310 379 379 LEU LEU A . n A 1 311 TYR 311 380 380 TYR TYR A . n A 1 312 VAL 312 381 381 VAL VAL A . n A 1 313 LYS 313 382 382 LYS LYS A . n A 1 314 TYR 314 383 383 TYR TYR A . n A 1 315 ASP 315 384 384 ASP ASP A . n A 1 316 GLY 316 385 385 GLY GLY A . n A 1 317 ASP 317 386 386 ASP ASP A . n A 1 318 PRO 318 387 387 PRO PRO A . n A 1 319 TRP 319 388 388 TRP TRP A . n A 1 320 THR 320 389 389 THR THR A . n A 1 321 ASP 321 390 390 ASP ASP A . n A 1 322 SER 322 391 391 SER SER A . n A 1 323 ASP 323 392 392 ASP ASP A . n A 1 324 ALA 324 393 393 ALA ALA A . n A 1 325 LEU 325 394 394 LEU LEU A . n A 1 326 ALA 326 395 395 ALA ALA A . n A 1 327 LEU 327 396 396 LEU LEU A . n A 1 328 SER 328 397 397 SER SER A . n A 1 329 GLY 329 398 398 GLY GLY A . n A 1 330 VAL 330 399 399 VAL VAL A . n A 1 331 MET 331 400 400 MET MET A . n A 1 332 VAL 332 401 401 VAL VAL A . n A 1 333 SER 333 402 402 SER SER A . n A 1 334 MET 334 403 403 MET MET A . n A 1 335 GLU 335 404 404 GLU GLU A . n A 1 336 GLU 336 405 405 GLU GLU A . n A 1 337 PRO 337 406 406 PRO PRO A . n A 1 338 GLY 338 407 407 GLY GLY A . n A 1 339 TRP 339 408 408 TRP TRP A . n A 1 340 TYR 340 409 409 TYR TYR A . n A 1 341 SER 341 410 410 SER SER A . n A 1 342 PHE 342 411 411 PHE PHE A . n A 1 343 GLY 343 412 412 GLY GLY A . n A 1 344 PHE 344 413 413 PHE PHE A . n A 1 345 GLU 345 414 414 GLU GLU A . n A 1 346 ILE 346 415 415 ILE ILE A . n A 1 347 LYS 347 416 416 LYS LYS A . n A 1 348 ASP 348 417 417 ASP ASP A . n A 1 349 LYS 349 418 418 LYS LYS A . n A 1 350 LYS 350 419 419 LYS LYS A . n A 1 351 CYS 351 420 420 CYS CYS A . n A 1 352 ASP 352 421 421 ASP ASP A . n A 1 353 VAL 353 422 422 VAL VAL A . n A 1 354 PRO 354 423 423 PRO PRO A . n A 1 355 CYS 355 424 424 CYS CYS A . n A 1 356 ILE 356 425 425 ILE ILE A . n A 1 357 GLY 357 426 426 GLY GLY A . n A 1 358 ILE 358 427 427 ILE ILE A . n A 1 359 GLU 359 428 428 GLU GLU A . n A 1 360 MET 360 429 429 MET MET A . n A 1 361 VAL 361 430 430 VAL VAL A . n A 1 362 HIS 362 431 431 HIS HIS A . n A 1 363 ASP 363 432 432 ASP ASP A . n A 1 364 GLY 364 433 433 GLY GLY A . n A 1 365 GLY 365 434 434 GLY GLY A . n A 1 366 LYS 366 435 435 LYS LYS A . n A 1 367 GLU 367 436 436 GLU GLU A . n A 1 368 THR 368 437 437 THR THR A . n A 1 369 TRP 369 438 438 TRP TRP A . n A 1 370 HIS 370 439 439 HIS HIS A . n A 1 371 SER 371 440 440 SER SER A . n A 1 372 ALA 372 441 441 ALA ALA A . n A 1 373 ALA 373 442 442 ALA ALA A . n A 1 374 THR 374 443 443 THR THR A . n A 1 375 ALA 375 444 444 ALA ALA A . n A 1 376 ILE 376 445 445 ILE ILE A . n A 1 377 TYR 377 446 446 TYR TYR A . n A 1 378 CYS 378 447 447 CYS CYS A . n A 1 379 LEU 379 448 448 LEU LEU A . n A 1 380 MET 380 449 449 MET MET A . n A 1 381 GLY 381 450 450 GLY GLY A . n A 1 382 SER 382 451 451 SER SER A . n A 1 383 GLY 383 452 452 GLY GLY A . n A 1 384 GLN 384 453 453 GLN GLN A . n A 1 385 LEU 385 454 454 LEU LEU A . n A 1 386 LEU 386 455 455 LEU LEU A . n A 1 387 TRP 387 456 456 TRP TRP A . n A 1 388 ASP 388 457 457 ASP ASP A . n A 1 389 THR 389 458 458 THR THR A . n A 1 390 VAL 390 459 459 VAL VAL A . n A 1 391 THR 391 460 460 THR THR A . n A 1 392 GLY 392 461 461 GLY GLY A . n A 1 393 VAL 393 462 462 VAL VAL A . n A 1 394 ASP 394 463 463 ASP ASP A . n A 1 395 MET 395 464 464 MET MET A . n A 1 396 ALA 396 465 465 ALA ALA A . n A 1 397 LEU 397 466 466 LEU LEU A . n B 1 1 GLY 1 70 ? ? ? B . n B 1 2 VAL 2 71 ? ? ? B . n B 1 3 THR 3 72 ? ? ? B . n B 1 4 LEU 4 73 ? ? ? B . n B 1 5 LEU 5 74 ? ? ? B . n B 1 6 LEU 6 75 ? ? ? B . n B 1 7 PRO 7 76 ? ? ? B . n B 1 8 GLU 8 77 ? ? ? B . n B 1 9 PRO 9 78 78 PRO PRO B . n B 1 10 GLU 10 79 79 GLU GLU B . n B 1 11 TRP 11 80 80 TRP TRP B . n B 1 12 THR 12 81 81 THR THR B . n B 1 13 TYR 13 82 82 TYR TYR B . n B 1 14 PRO 14 83 83 PRO PRO B . n B 1 15 ARG 15 84 84 ARG ARG B . n B 1 16 LEU 16 85 85 LEU LEU B . n B 1 17 SER 17 86 86 SER SER B . n B 1 18 CYS 18 87 87 CYS CYS B . n B 1 19 PRO 19 88 88 PRO PRO B . n B 1 20 GLY 20 89 89 GLY GLY B . n B 1 21 SER 21 90 90 SER SER B . n B 1 22 THR 22 91 91 THR THR B . n B 1 23 PHE 23 92 92 PHE PHE B . n B 1 24 GLN 24 93 93 GLN GLN B . n B 1 25 LYS 25 94 94 LYS LYS B . n B 1 26 ALA 26 95 95 ALA ALA B . n B 1 27 LEU 27 96 96 LEU LEU B . n B 1 28 LEU 28 97 97 LEU LEU B . n B 1 29 ILE 29 98 98 ILE ILE B . n B 1 30 SER 30 99 99 SER SER B . n B 1 31 PRO 31 100 100 PRO PRO B . n B 1 32 HIS 32 101 101 HIS HIS B . n B 1 33 ARG 33 102 102 ARG ARG B . n B 1 34 PHE 34 103 103 PHE PHE B . n B 1 35 GLY 35 104 104 GLY GLY B . n B 1 36 GLU 36 105 105 GLU GLU B . n B 1 37 THR 37 106 106 THR THR B . n B 1 38 LYS 38 107 107 LYS LYS B . n B 1 39 GLY 39 108 108 GLY GLY B . n B 1 40 ASN 40 109 109 ASN ASN B . n B 1 41 SER 41 110 110 SER SER B . n B 1 42 ALA 42 111 111 ALA ALA B . n B 1 43 PRO 43 112 112 PRO PRO B . n B 1 44 LEU 44 113 113 LEU LEU B . n B 1 45 ILE 45 114 114 ILE ILE B . n B 1 46 ILE 46 115 115 ILE ILE B . n B 1 47 ARG 47 116 116 ARG ARG B . n B 1 48 GLU 48 117 117 GLU GLU B . n B 1 49 PRO 49 118 118 PRO PRO B . n B 1 50 PHE 50 119 119 PHE PHE B . n B 1 51 ILE 51 120 120 ILE ILE B . n B 1 52 ALA 52 121 121 ALA ALA B . n B 1 53 CYS 53 122 122 CYS CYS B . n B 1 54 GLY 54 123 123 GLY GLY B . n B 1 55 PRO 55 124 124 PRO PRO B . n B 1 56 LYS 56 125 125 LYS LYS B . n B 1 57 GLU 57 126 126 GLU GLU B . n B 1 58 CYS 58 127 127 CYS CYS B . n B 1 59 LYS 59 128 128 LYS LYS B . n B 1 60 HIS 60 129 129 HIS HIS B . n B 1 61 PHE 61 130 130 PHE PHE B . n B 1 62 ALA 62 131 131 ALA ALA B . n B 1 63 LEU 63 132 132 LEU LEU B . n B 1 64 THR 64 133 133 THR THR B . n B 1 65 HIS 65 134 134 HIS HIS B . n B 1 66 TYR 66 135 135 TYR TYR B . n B 1 67 ALA 67 136 136 ALA ALA B . n B 1 68 ALA 68 137 137 ALA ALA B . n B 1 69 GLN 69 138 138 GLN GLN B . n B 1 70 PRO 70 139 139 PRO PRO B . n B 1 71 GLY 71 140 140 GLY GLY B . n B 1 72 GLY 72 141 141 GLY GLY B . n B 1 73 TYR 73 142 142 TYR TYR B . n B 1 74 TYR 74 143 143 TYR TYR B . n B 1 75 ASN 75 144 144 ASN ASN B . n B 1 76 GLY 76 145 145 GLY GLY B . n B 1 77 THR 77 146 146 THR THR B . n B 1 78 ARG 78 147 147 ARG ARG B . n B 1 79 GLY 79 148 148 GLY GLY B . n B 1 80 ASP 80 149 149 ASP ASP B . n B 1 81 ARG 81 150 150 ARG ARG B . n B 1 82 ASN 82 151 151 ASN ASN B . n B 1 83 LYS 83 152 152 LYS LYS B . n B 1 84 LEU 84 153 153 LEU LEU B . n B 1 85 ARG 85 154 154 ARG ARG B . n B 1 86 HIS 86 155 155 HIS HIS B . n B 1 87 LEU 87 156 156 LEU LEU B . n B 1 88 ILE 88 157 157 ILE ILE B . n B 1 89 SER 89 158 158 SER SER B . n B 1 90 VAL 90 159 159 VAL VAL B . n B 1 91 LYS 91 160 160 LYS LYS B . n B 1 92 LEU 92 161 161 LEU LEU B . n B 1 93 GLY 93 162 162 GLY GLY B . n B 1 94 LYS 94 163 163 LYS LYS B . n B 1 95 ILE 95 164 164 ILE ILE B . n B 1 96 PRO 96 165 165 PRO PRO B . n B 1 97 THR 97 166 166 THR THR B . n B 1 98 VAL 98 167 167 VAL VAL B . n B 1 99 GLU 99 168 168 GLU GLU B . n B 1 100 ASN 100 169 169 ASN ASN B . n B 1 101 SER 101 170 170 SER SER B . n B 1 102 ILE 102 171 171 ILE ILE B . n B 1 103 PHE 103 172 172 PHE PHE B . n B 1 104 HIS 104 173 173 HIS HIS B . n B 1 105 MET 105 174 174 MET MET B . n B 1 106 ALA 106 175 175 ALA ALA B . n B 1 107 ALA 107 176 176 ALA ALA B . n B 1 108 TRP 108 177 177 TRP TRP B . n B 1 109 SER 109 178 178 SER SER B . n B 1 110 GLY 110 179 179 GLY GLY B . n B 1 111 SER 111 180 180 SER SER B . n B 1 112 ALA 112 181 181 ALA ALA B . n B 1 113 CYS 113 182 182 CYS CYS B . n B 1 114 HIS 114 183 183 HIS HIS B . n B 1 115 ASP 115 184 184 ASP ASP B . n B 1 116 GLY 116 185 185 GLY GLY B . n B 1 117 LYS 117 186 186 LYS LYS B . n B 1 118 GLU 118 187 187 GLU GLU B . n B 1 119 TRP 119 188 188 TRP TRP B . n B 1 120 THR 120 189 189 THR THR B . n B 1 121 TYR 121 190 190 TYR TYR B . n B 1 122 ILE 122 191 191 ILE ILE B . n B 1 123 GLY 123 192 192 GLY GLY B . n B 1 124 VAL 124 193 193 VAL VAL B . n B 1 125 ASP 125 194 194 ASP ASP B . n B 1 126 GLY 126 195 195 GLY GLY B . n B 1 127 PRO 127 196 196 PRO PRO B . n B 1 128 ASP 128 197 197 ASP ASP B . n B 1 129 ASN 129 198 198 ASN ASN B . n B 1 130 ASN 130 199 199 ASN ASN B . n B 1 131 ALA 131 200 200 ALA ALA B . n B 1 132 LEU 132 201 201 LEU LEU B . n B 1 133 LEU 133 202 202 LEU LEU B . n B 1 134 LYS 134 203 203 LYS LYS B . n B 1 135 ILE 135 204 204 ILE ILE B . n B 1 136 LYS 136 205 205 LYS LYS B . n B 1 137 TYR 137 206 206 TYR TYR B . n B 1 138 GLY 138 207 207 GLY GLY B . n B 1 139 GLU 139 208 208 GLU GLU B . n B 1 140 ALA 140 209 209 ALA ALA B . n B 1 141 TYR 141 210 210 TYR TYR B . n B 1 142 THR 142 211 211 THR THR B . n B 1 143 ASP 143 212 212 ASP ASP B . n B 1 144 THR 144 213 213 THR THR B . n B 1 145 TYR 145 214 214 TYR TYR B . n B 1 146 HIS 146 215 215 HIS HIS B . n B 1 147 SER 147 216 216 SER SER B . n B 1 148 TYR 148 217 217 TYR TYR B . n B 1 149 ALA 149 218 218 ALA ALA B . n B 1 150 ASN 150 219 219 ASN ASN B . n B 1 151 ASN 151 220 220 ASN ASN B . n B 1 152 ILE 152 221 221 ILE ILE B . n B 1 153 LEU 153 222 222 LEU LEU B . n B 1 154 ARG 154 223 223 ARG ARG B . n B 1 155 THR 155 224 224 THR THR B . n B 1 156 GLN 156 225 225 GLN GLN B . n B 1 157 GLU 157 226 226 GLU GLU B . n B 1 158 SER 158 227 227 SER SER B . n B 1 159 ALA 159 228 228 ALA ALA B . n B 1 160 CYS 160 229 229 CYS CYS B . n B 1 161 ASN 161 230 230 ASN ASN B . n B 1 162 CYS 162 231 231 CYS CYS B . n B 1 163 ILE 163 232 232 ILE ILE B . n B 1 164 GLY 164 233 233 GLY GLY B . n B 1 165 GLY 165 234 234 GLY GLY B . n B 1 166 ASN 166 235 235 ASN ASN B . n B 1 167 CYS 167 236 236 CYS CYS B . n B 1 168 TYR 168 237 237 TYR TYR B . n B 1 169 LEU 169 238 238 LEU LEU B . n B 1 170 MET 170 239 239 MET MET B . n B 1 171 ILE 171 240 240 ILE ILE B . n B 1 172 THR 172 241 241 THR THR B . n B 1 173 ASP 173 242 242 ASP ASP B . n B 1 174 GLY 174 243 243 GLY GLY B . n B 1 175 SER 175 244 244 SER SER B . n B 1 176 ALA 176 245 245 ALA ALA B . n B 1 177 SER 177 246 246 SER SER B . n B 1 178 GLY 178 247 247 GLY GLY B . n B 1 179 ILE 179 248 248 ILE ILE B . n B 1 180 SER 180 249 249 SER SER B . n B 1 181 GLU 181 250 250 GLU GLU B . n B 1 182 CYS 182 251 251 CYS CYS B . n B 1 183 ARG 183 252 252 ARG ARG B . n B 1 184 PHE 184 253 253 PHE PHE B . n B 1 185 LEU 185 254 254 LEU LEU B . n B 1 186 LYS 186 255 255 LYS LYS B . n B 1 187 ILE 187 256 256 ILE ILE B . n B 1 188 ARG 188 257 257 ARG ARG B . n B 1 189 GLU 189 258 258 GLU GLU B . n B 1 190 GLY 190 259 259 GLY GLY B . n B 1 191 ARG 191 260 260 ARG ARG B . n B 1 192 ILE 192 261 261 ILE ILE B . n B 1 193 ILE 193 262 262 ILE ILE B . n B 1 194 LYS 194 263 263 LYS LYS B . n B 1 195 GLU 195 264 264 GLU GLU B . n B 1 196 ILE 196 265 265 ILE ILE B . n B 1 197 PHE 197 266 266 PHE PHE B . n B 1 198 PRO 198 267 267 PRO PRO B . n B 1 199 THR 199 268 268 THR THR B . n B 1 200 GLY 200 269 269 GLY GLY B . n B 1 201 ARG 201 270 270 ARG ARG B . n B 1 202 VAL 202 271 271 VAL VAL B . n B 1 203 LYS 203 272 272 LYS LYS B . n B 1 204 HIS 204 273 273 HIS HIS B . n B 1 205 THR 205 274 274 THR THR B . n B 1 206 GLU 206 275 275 GLU GLU B . n B 1 207 GLU 207 276 276 GLU GLU B . n B 1 208 CYS 208 277 277 CYS CYS B . n B 1 209 THR 209 278 278 THR THR B . n B 1 210 CYS 210 279 279 CYS CYS B . n B 1 211 GLY 211 280 280 GLY GLY B . n B 1 212 PHE 212 281 281 PHE PHE B . n B 1 213 ALA 213 282 282 ALA ALA B . n B 1 214 SER 214 283 283 SER SER B . n B 1 215 ASN 215 284 284 ASN ASN B . n B 1 216 LYS 216 285 285 LYS LYS B . n B 1 217 THR 217 286 286 THR THR B . n B 1 218 ILE 218 287 287 ILE ILE B . n B 1 219 GLU 219 288 288 GLU GLU B . n B 1 220 CYS 220 289 289 CYS CYS B . n B 1 221 ALA 221 290 290 ALA ALA B . n B 1 222 CYS 222 291 291 CYS CYS B . n B 1 223 ARG 223 292 292 ARG ARG B . n B 1 224 ASP 224 293 293 ASP ASP B . n B 1 225 ASN 225 294 294 ASN ASN B . n B 1 226 SER 226 295 295 SER SER B . n B 1 227 TYR 227 296 296 TYR TYR B . n B 1 228 THR 228 297 297 THR THR B . n B 1 229 ALA 229 298 298 ALA ALA B . n B 1 230 LYS 230 299 299 LYS LYS B . n B 1 231 ARG 231 300 300 ARG ARG B . n B 1 232 PRO 232 301 301 PRO PRO B . n B 1 233 PHE 233 302 302 PHE PHE B . n B 1 234 VAL 234 303 303 VAL VAL B . n B 1 235 LYS 235 304 304 LYS LYS B . n B 1 236 LEU 236 305 305 LEU LEU B . n B 1 237 ASN 237 306 306 ASN ASN B . n B 1 238 VAL 238 307 307 VAL VAL B . n B 1 239 GLU 239 308 308 GLU GLU B . n B 1 240 THR 240 309 309 THR THR B . n B 1 241 ASP 241 310 310 ASP ASP B . n B 1 242 THR 242 311 311 THR THR B . n B 1 243 ALA 243 312 312 ALA ALA B . n B 1 244 GLU 244 313 313 GLU GLU B . n B 1 245 ILE 245 314 314 ILE ILE B . n B 1 246 ARG 246 315 315 ARG ARG B . n B 1 247 LEU 247 316 316 LEU LEU B . n B 1 248 MET 248 317 317 MET MET B . n B 1 249 CYS 249 318 318 CYS CYS B . n B 1 250 THR 250 319 319 THR THR B . n B 1 251 GLU 251 320 320 GLU GLU B . n B 1 252 THR 252 321 321 THR THR B . n B 1 253 TYR 253 322 322 TYR TYR B . n B 1 254 LEU 254 323 323 LEU LEU B . n B 1 255 ASP 255 324 324 ASP ASP B . n B 1 256 THR 256 325 325 THR THR B . n B 1 257 PRO 257 326 326 PRO PRO B . n B 1 258 ARG 258 327 327 ARG ARG B . n B 1 259 PRO 259 328 328 PRO PRO B . n B 1 260 ASP 260 329 329 ASP ASP B . n B 1 261 ASP 261 330 330 ASP ASP B . n B 1 262 GLY 262 331 331 GLY GLY B . n B 1 263 SER 263 332 332 SER SER B . n B 1 264 ILE 264 333 333 ILE ILE B . n B 1 265 THR 265 334 334 THR THR B . n B 1 266 GLY 266 335 335 GLY GLY B . n B 1 267 PRO 267 336 336 PRO PRO B . n B 1 268 CYS 268 337 337 CYS CYS B . n B 1 269 GLU 269 338 338 GLU GLU B . n B 1 270 SER 270 339 339 SER SER B . n B 1 271 ASN 271 340 340 ASN ASN B . n B 1 272 GLY 272 341 341 GLY GLY B . n B 1 273 ASP 273 342 342 ASP ASP B . n B 1 274 LYS 274 343 343 LYS LYS B . n B 1 275 GLY 275 344 344 GLY GLY B . n B 1 276 SER 276 345 345 SER SER B . n B 1 277 GLY 277 346 346 GLY GLY B . n B 1 278 GLY 278 347 347 GLY GLY B . n B 1 279 ILE 279 348 348 ILE ILE B . n B 1 280 LYS 280 349 349 LYS LYS B . n B 1 281 GLY 281 350 350 GLY GLY B . n B 1 282 GLY 282 351 351 GLY GLY B . n B 1 283 PHE 283 352 352 PHE PHE B . n B 1 284 VAL 284 353 353 VAL VAL B . n B 1 285 HIS 285 354 354 HIS HIS B . n B 1 286 GLN 286 355 355 GLN GLN B . n B 1 287 ARG 287 356 356 ARG ARG B . n B 1 288 MET 288 357 357 MET MET B . n B 1 289 ALA 289 358 358 ALA ALA B . n B 1 290 SER 290 359 359 SER SER B . n B 1 291 LYS 291 360 360 LYS LYS B . n B 1 292 ILE 292 361 361 ILE ILE B . n B 1 293 GLY 293 362 362 GLY GLY B . n B 1 294 ARG 294 363 363 ARG ARG B . n B 1 295 TRP 295 364 364 TRP TRP B . n B 1 296 TYR 296 365 365 TYR TYR B . n B 1 297 SER 297 366 366 SER SER B . n B 1 298 ARG 298 367 367 ARG ARG B . n B 1 299 THR 299 368 368 THR THR B . n B 1 300 MET 300 369 369 MET MET B . n B 1 301 SER 301 370 370 SER SER B . n B 1 302 LYS 302 371 371 LYS LYS B . n B 1 303 THR 303 372 372 THR THR B . n B 1 304 LYS 304 373 373 LYS LYS B . n B 1 305 ARG 305 374 374 ARG ARG B . n B 1 306 MET 306 375 375 MET MET B . n B 1 307 GLY 307 376 376 GLY GLY B . n B 1 308 MET 308 377 377 MET MET B . n B 1 309 GLY 309 378 378 GLY GLY B . n B 1 310 LEU 310 379 379 LEU LEU B . n B 1 311 TYR 311 380 380 TYR TYR B . n B 1 312 VAL 312 381 381 VAL VAL B . n B 1 313 LYS 313 382 382 LYS LYS B . n B 1 314 TYR 314 383 383 TYR TYR B . n B 1 315 ASP 315 384 384 ASP ASP B . n B 1 316 GLY 316 385 385 GLY GLY B . n B 1 317 ASP 317 386 386 ASP ASP B . n B 1 318 PRO 318 387 387 PRO PRO B . n B 1 319 TRP 319 388 388 TRP TRP B . n B 1 320 THR 320 389 389 THR THR B . n B 1 321 ASP 321 390 390 ASP ASP B . n B 1 322 SER 322 391 391 SER SER B . n B 1 323 ASP 323 392 392 ASP ASP B . n B 1 324 ALA 324 393 393 ALA ALA B . n B 1 325 LEU 325 394 394 LEU LEU B . n B 1 326 ALA 326 395 395 ALA ALA B . n B 1 327 LEU 327 396 396 LEU LEU B . n B 1 328 SER 328 397 397 SER SER B . n B 1 329 GLY 329 398 398 GLY GLY B . n B 1 330 VAL 330 399 399 VAL VAL B . n B 1 331 MET 331 400 400 MET MET B . n B 1 332 VAL 332 401 401 VAL VAL B . n B 1 333 SER 333 402 402 SER SER B . n B 1 334 MET 334 403 403 MET MET B . n B 1 335 GLU 335 404 404 GLU GLU B . n B 1 336 GLU 336 405 405 GLU GLU B . n B 1 337 PRO 337 406 406 PRO PRO B . n B 1 338 GLY 338 407 407 GLY GLY B . n B 1 339 TRP 339 408 408 TRP TRP B . n B 1 340 TYR 340 409 409 TYR TYR B . n B 1 341 SER 341 410 410 SER SER B . n B 1 342 PHE 342 411 411 PHE PHE B . n B 1 343 GLY 343 412 412 GLY GLY B . n B 1 344 PHE 344 413 413 PHE PHE B . n B 1 345 GLU 345 414 414 GLU GLU B . n B 1 346 ILE 346 415 415 ILE ILE B . n B 1 347 LYS 347 416 416 LYS LYS B . n B 1 348 ASP 348 417 417 ASP ASP B . n B 1 349 LYS 349 418 418 LYS LYS B . n B 1 350 LYS 350 419 419 LYS LYS B . n B 1 351 CYS 351 420 420 CYS CYS B . n B 1 352 ASP 352 421 421 ASP ASP B . n B 1 353 VAL 353 422 422 VAL VAL B . n B 1 354 PRO 354 423 423 PRO PRO B . n B 1 355 CYS 355 424 424 CYS CYS B . n B 1 356 ILE 356 425 425 ILE ILE B . n B 1 357 GLY 357 426 426 GLY GLY B . n B 1 358 ILE 358 427 427 ILE ILE B . n B 1 359 GLU 359 428 428 GLU GLU B . n B 1 360 MET 360 429 429 MET MET B . n B 1 361 VAL 361 430 430 VAL VAL B . n B 1 362 HIS 362 431 431 HIS HIS B . n B 1 363 ASP 363 432 432 ASP ASP B . n B 1 364 GLY 364 433 433 GLY GLY B . n B 1 365 GLY 365 434 434 GLY GLY B . n B 1 366 LYS 366 435 435 LYS LYS B . n B 1 367 GLU 367 436 436 GLU GLU B . n B 1 368 THR 368 437 437 THR THR B . n B 1 369 TRP 369 438 438 TRP TRP B . n B 1 370 HIS 370 439 439 HIS HIS B . n B 1 371 SER 371 440 440 SER SER B . n B 1 372 ALA 372 441 441 ALA ALA B . n B 1 373 ALA 373 442 442 ALA ALA B . n B 1 374 THR 374 443 443 THR THR B . n B 1 375 ALA 375 444 444 ALA ALA B . n B 1 376 ILE 376 445 445 ILE ILE B . n B 1 377 TYR 377 446 446 TYR TYR B . n B 1 378 CYS 378 447 447 CYS CYS B . n B 1 379 LEU 379 448 448 LEU LEU B . n B 1 380 MET 380 449 449 MET MET B . n B 1 381 GLY 381 450 450 GLY GLY B . n B 1 382 SER 382 451 451 SER SER B . n B 1 383 GLY 383 452 452 GLY GLY B . n B 1 384 GLN 384 453 453 GLN GLN B . n B 1 385 LEU 385 454 454 LEU LEU B . n B 1 386 LEU 386 455 455 LEU LEU B . n B 1 387 TRP 387 456 456 TRP TRP B . n B 1 388 ASP 388 457 457 ASP ASP B . n B 1 389 THR 389 458 458 THR THR B . n B 1 390 VAL 390 459 459 VAL VAL B . n B 1 391 THR 391 460 460 THR THR B . n B 1 392 GLY 392 461 461 GLY GLY B . n B 1 393 VAL 393 462 462 VAL VAL B . n B 1 394 ASP 394 463 463 ASP ASP B . n B 1 395 MET 395 464 464 MET MET B . n B 1 396 ALA 396 465 465 ALA ALA B . n B 1 397 LEU 397 466 466 LEU LEU B . n # loop_ _pdbx_nonpoly_scheme.asym_id _pdbx_nonpoly_scheme.entity_id _pdbx_nonpoly_scheme.mon_id _pdbx_nonpoly_scheme.ndb_seq_num _pdbx_nonpoly_scheme.pdb_seq_num _pdbx_nonpoly_scheme.auth_seq_num _pdbx_nonpoly_scheme.pdb_mon_id _pdbx_nonpoly_scheme.auth_mon_id _pdbx_nonpoly_scheme.pdb_strand_id _pdbx_nonpoly_scheme.pdb_ins_code C 2 NAG 1 1 1 NAG NAG A . D 2 NAG 2 2 2 NAG NAG A . E 3 BMA 3 3 3 BMA BMA A . F 4 MAN 4 4 4 MAN MAN A . G 4 MAN 5 5 5 MAN MAN A . H 4 MAN 6 6 6 MAN MAN A . I 5 SO4 1 467 1 SO4 SO4 A . J 6 EDO 1 468 2 EDO EDO A . K 7 GOL 1 469 3 GOL GOL A . L 8 CA 1 470 2 CA CA A . M 2 NAG 1 1 1 NAG NAG B . N 2 NAG 2 2 2 NAG NAG B . O 3 BMA 3 3 3 BMA BMA B . P 4 MAN 4 4 4 MAN MAN B . Q 4 MAN 5 5 5 MAN MAN B . R 4 MAN 6 6 6 MAN MAN B . S 5 SO4 1 467 2 SO4 SO4 B . T 6 EDO 1 468 1 EDO EDO B . U 7 GOL 1 469 1 GOL GOL B . V 7 GOL 1 470 2 GOL GOL B . W 7 GOL 1 471 5 GOL GOL B . X 8 CA 1 472 1 CA CA B . Y 9 HOH 1 7 7 HOH HOH A . Y 9 HOH 2 11 11 HOH HOH A . Y 9 HOH 3 12 12 HOH HOH A . Y 9 HOH 4 15 15 HOH HOH A . Y 9 HOH 5 16 16 HOH HOH A . Y 9 HOH 6 19 19 HOH HOH A . Y 9 HOH 7 24 24 HOH HOH A . Y 9 HOH 8 25 25 HOH HOH A . Y 9 HOH 9 27 27 HOH HOH A . Y 9 HOH 10 29 29 HOH HOH A . Y 9 HOH 11 30 30 HOH HOH A . Y 9 HOH 12 38 38 HOH HOH A . Y 9 HOH 13 42 42 HOH HOH A . Y 9 HOH 14 43 43 HOH HOH A . Y 9 HOH 15 44 44 HOH HOH A . Y 9 HOH 16 47 47 HOH HOH A . Y 9 HOH 17 50 50 HOH HOH A . Y 9 HOH 18 51 51 HOH HOH A . Y 9 HOH 19 55 55 HOH HOH A . Y 9 HOH 20 57 57 HOH HOH A . Y 9 HOH 21 61 61 HOH HOH A . Y 9 HOH 22 62 62 HOH HOH A . Y 9 HOH 23 63 63 HOH HOH A . Y 9 HOH 24 64 64 HOH HOH A . Y 9 HOH 25 65 65 HOH HOH A . Y 9 HOH 26 68 68 HOH HOH A . Y 9 HOH 27 69 69 HOH HOH A . Y 9 HOH 28 471 1 HOH HOH A . Y 9 HOH 29 472 3 HOH HOH A . Y 9 HOH 30 473 4 HOH HOH A . Y 9 HOH 31 474 5 HOH HOH A . Y 9 HOH 32 475 6 HOH HOH A . Y 9 HOH 33 476 70 HOH HOH A . Y 9 HOH 34 477 72 HOH HOH A . Y 9 HOH 35 478 76 HOH HOH A . Y 9 HOH 36 479 77 HOH HOH A . Y 9 HOH 37 480 78 HOH HOH A . Y 9 HOH 38 481 87 HOH HOH A . Y 9 HOH 39 482 88 HOH HOH A . Y 9 HOH 40 483 89 HOH HOH A . Y 9 HOH 41 484 92 HOH HOH A . Y 9 HOH 42 485 93 HOH HOH A . Y 9 HOH 43 486 95 HOH HOH A . Y 9 HOH 44 487 98 HOH HOH A . Y 9 HOH 45 488 101 HOH HOH A . Y 9 HOH 46 489 102 HOH HOH A . Y 9 HOH 47 490 103 HOH HOH A . Y 9 HOH 48 491 104 HOH HOH A . Y 9 HOH 49 492 109 HOH HOH A . Y 9 HOH 50 493 110 HOH HOH A . Y 9 HOH 51 494 112 HOH HOH A . Y 9 HOH 52 495 114 HOH HOH A . Y 9 HOH 53 496 115 HOH HOH A . Y 9 HOH 54 497 118 HOH HOH A . Y 9 HOH 55 498 119 HOH HOH A . Y 9 HOH 56 499 120 HOH HOH A . Y 9 HOH 57 500 122 HOH HOH A . Y 9 HOH 58 501 125 HOH HOH A . Y 9 HOH 59 502 126 HOH HOH A . Y 9 HOH 60 503 127 HOH HOH A . Y 9 HOH 61 504 129 HOH HOH A . Y 9 HOH 62 505 131 HOH HOH A . Y 9 HOH 63 506 132 HOH HOH A . Y 9 HOH 64 507 135 HOH HOH A . Y 9 HOH 65 508 137 HOH HOH A . Y 9 HOH 66 509 138 HOH HOH A . Y 9 HOH 67 510 139 HOH HOH A . Y 9 HOH 68 511 141 HOH HOH A . Y 9 HOH 69 512 143 HOH HOH A . Y 9 HOH 70 513 148 HOH HOH A . Y 9 HOH 71 514 151 HOH HOH A . Y 9 HOH 72 515 155 HOH HOH A . Y 9 HOH 73 516 156 HOH HOH A . Y 9 HOH 74 517 157 HOH HOH A . Y 9 HOH 75 518 158 HOH HOH A . Y 9 HOH 76 519 161 HOH HOH A . Y 9 HOH 77 520 164 HOH HOH A . Y 9 HOH 78 521 165 HOH HOH A . Y 9 HOH 79 522 167 HOH HOH A . Y 9 HOH 80 523 170 HOH HOH A . Y 9 HOH 81 524 172 HOH HOH A . Y 9 HOH 82 525 173 HOH HOH A . Y 9 HOH 83 526 174 HOH HOH A . Y 9 HOH 84 527 175 HOH HOH A . Y 9 HOH 85 528 176 HOH HOH A . Y 9 HOH 86 529 177 HOH HOH A . Y 9 HOH 87 530 180 HOH HOH A . Y 9 HOH 88 531 182 HOH HOH A . Y 9 HOH 89 532 184 HOH HOH A . Y 9 HOH 90 533 185 HOH HOH A . Y 9 HOH 91 534 187 HOH HOH A . Y 9 HOH 92 535 188 HOH HOH A . Y 9 HOH 93 536 189 HOH HOH A . Y 9 HOH 94 537 190 HOH HOH A . Y 9 HOH 95 538 191 HOH HOH A . Y 9 HOH 96 539 193 HOH HOH A . Y 9 HOH 97 540 195 HOH HOH A . Y 9 HOH 98 541 199 HOH HOH A . Y 9 HOH 99 542 200 HOH HOH A . Y 9 HOH 100 543 205 HOH HOH A . Y 9 HOH 101 544 206 HOH HOH A . Y 9 HOH 102 545 207 HOH HOH A . Y 9 HOH 103 546 208 HOH HOH A . Y 9 HOH 104 547 209 HOH HOH A . Y 9 HOH 105 548 210 HOH HOH A . Y 9 HOH 106 549 211 HOH HOH A . Y 9 HOH 107 550 215 HOH HOH A . Y 9 HOH 108 551 216 HOH HOH A . Y 9 HOH 109 552 218 HOH HOH A . Y 9 HOH 110 553 219 HOH HOH A . Y 9 HOH 111 554 220 HOH HOH A . Y 9 HOH 112 555 222 HOH HOH A . Y 9 HOH 113 556 224 HOH HOH A . Y 9 HOH 114 557 226 HOH HOH A . Y 9 HOH 115 558 228 HOH HOH A . Y 9 HOH 116 559 230 HOH HOH A . Y 9 HOH 117 560 233 HOH HOH A . Y 9 HOH 118 561 234 HOH HOH A . Y 9 HOH 119 562 235 HOH HOH A . Y 9 HOH 120 563 236 HOH HOH A . Y 9 HOH 121 564 238 HOH HOH A . Y 9 HOH 122 565 240 HOH HOH A . Y 9 HOH 123 566 244 HOH HOH A . Y 9 HOH 124 567 245 HOH HOH A . Y 9 HOH 125 568 246 HOH HOH A . Y 9 HOH 126 569 248 HOH HOH A . Y 9 HOH 127 570 249 HOH HOH A . Y 9 HOH 128 571 250 HOH HOH A . Y 9 HOH 129 572 252 HOH HOH A . Y 9 HOH 130 573 254 HOH HOH A . Y 9 HOH 131 574 255 HOH HOH A . Y 9 HOH 132 575 256 HOH HOH A . Y 9 HOH 133 576 261 HOH HOH A . Y 9 HOH 134 577 262 HOH HOH A . Y 9 HOH 135 578 264 HOH HOH A . Y 9 HOH 136 579 268 HOH HOH A . Y 9 HOH 137 580 269 HOH HOH A . Y 9 HOH 138 581 274 HOH HOH A . Y 9 HOH 139 582 275 HOH HOH A . Y 9 HOH 140 583 276 HOH HOH A . Y 9 HOH 141 584 277 HOH HOH A . Y 9 HOH 142 585 278 HOH HOH A . Y 9 HOH 143 586 279 HOH HOH A . Y 9 HOH 144 587 280 HOH HOH A . Y 9 HOH 145 588 284 HOH HOH A . Y 9 HOH 146 589 286 HOH HOH A . Y 9 HOH 147 590 288 HOH HOH A . Y 9 HOH 148 591 289 HOH HOH A . Y 9 HOH 149 592 291 HOH HOH A . Y 9 HOH 150 593 292 HOH HOH A . Y 9 HOH 151 594 295 HOH HOH A . Y 9 HOH 152 595 296 HOH HOH A . Y 9 HOH 153 596 297 HOH HOH A . Y 9 HOH 154 597 301 HOH HOH A . Y 9 HOH 155 598 302 HOH HOH A . Y 9 HOH 156 599 303 HOH HOH A . Y 9 HOH 157 600 305 HOH HOH A . Y 9 HOH 158 601 308 HOH HOH A . Y 9 HOH 159 602 311 HOH HOH A . Y 9 HOH 160 603 312 HOH HOH A . Y 9 HOH 161 604 313 HOH HOH A . Y 9 HOH 162 605 315 HOH HOH A . Y 9 HOH 163 606 317 HOH HOH A . Y 9 HOH 164 607 319 HOH HOH A . Y 9 HOH 165 608 323 HOH HOH A . Y 9 HOH 166 609 324 HOH HOH A . Z 9 HOH 1 8 8 HOH HOH B . Z 9 HOH 2 9 9 HOH HOH B . Z 9 HOH 3 10 10 HOH HOH B . Z 9 HOH 4 13 13 HOH HOH B . Z 9 HOH 5 14 14 HOH HOH B . Z 9 HOH 6 17 17 HOH HOH B . Z 9 HOH 7 18 18 HOH HOH B . Z 9 HOH 8 20 20 HOH HOH B . Z 9 HOH 9 21 21 HOH HOH B . Z 9 HOH 10 22 22 HOH HOH B . Z 9 HOH 11 23 23 HOH HOH B . Z 9 HOH 12 26 26 HOH HOH B . Z 9 HOH 13 28 28 HOH HOH B . Z 9 HOH 14 31 31 HOH HOH B . Z 9 HOH 15 32 32 HOH HOH B . Z 9 HOH 16 33 33 HOH HOH B . Z 9 HOH 17 34 34 HOH HOH B . Z 9 HOH 18 35 35 HOH HOH B . Z 9 HOH 19 36 36 HOH HOH B . Z 9 HOH 20 37 37 HOH HOH B . Z 9 HOH 21 39 39 HOH HOH B . Z 9 HOH 22 40 40 HOH HOH B . Z 9 HOH 23 41 41 HOH HOH B . Z 9 HOH 24 45 45 HOH HOH B . Z 9 HOH 25 46 46 HOH HOH B . Z 9 HOH 26 48 48 HOH HOH B . Z 9 HOH 27 49 49 HOH HOH B . Z 9 HOH 28 52 52 HOH HOH B . Z 9 HOH 29 53 53 HOH HOH B . Z 9 HOH 30 54 54 HOH HOH B . Z 9 HOH 31 56 56 HOH HOH B . Z 9 HOH 32 58 58 HOH HOH B . Z 9 HOH 33 59 59 HOH HOH B . Z 9 HOH 34 60 60 HOH HOH B . Z 9 HOH 35 66 66 HOH HOH B . Z 9 HOH 36 67 67 HOH HOH B . Z 9 HOH 37 473 2 HOH HOH B . Z 9 HOH 38 474 71 HOH HOH B . Z 9 HOH 39 475 73 HOH HOH B . Z 9 HOH 40 476 74 HOH HOH B . Z 9 HOH 41 477 75 HOH HOH B . Z 9 HOH 42 478 79 HOH HOH B . Z 9 HOH 43 479 80 HOH HOH B . Z 9 HOH 44 480 81 HOH HOH B . Z 9 HOH 45 481 82 HOH HOH B . Z 9 HOH 46 482 83 HOH HOH B . Z 9 HOH 47 483 84 HOH HOH B . Z 9 HOH 48 484 85 HOH HOH B . Z 9 HOH 49 485 86 HOH HOH B . Z 9 HOH 50 486 90 HOH HOH B . Z 9 HOH 51 487 91 HOH HOH B . Z 9 HOH 52 488 94 HOH HOH B . Z 9 HOH 53 489 96 HOH HOH B . Z 9 HOH 54 490 97 HOH HOH B . Z 9 HOH 55 491 99 HOH HOH B . Z 9 HOH 56 492 100 HOH HOH B . Z 9 HOH 57 493 105 HOH HOH B . Z 9 HOH 58 494 106 HOH HOH B . Z 9 HOH 59 495 107 HOH HOH B . Z 9 HOH 60 496 108 HOH HOH B . Z 9 HOH 61 497 111 HOH HOH B . Z 9 HOH 62 498 113 HOH HOH B . Z 9 HOH 63 499 116 HOH HOH B . Z 9 HOH 64 500 117 HOH HOH B . Z 9 HOH 65 501 123 HOH HOH B . Z 9 HOH 66 502 124 HOH HOH B . Z 9 HOH 67 503 128 HOH HOH B . Z 9 HOH 68 504 130 HOH HOH B . Z 9 HOH 69 505 133 HOH HOH B . Z 9 HOH 70 506 134 HOH HOH B . Z 9 HOH 71 507 136 HOH HOH B . Z 9 HOH 72 508 140 HOH HOH B . Z 9 HOH 73 509 142 HOH HOH B . Z 9 HOH 74 510 144 HOH HOH B . Z 9 HOH 75 511 145 HOH HOH B . Z 9 HOH 76 512 146 HOH HOH B . Z 9 HOH 77 513 147 HOH HOH B . Z 9 HOH 78 514 149 HOH HOH B . Z 9 HOH 79 515 152 HOH HOH B . Z 9 HOH 80 516 153 HOH HOH B . Z 9 HOH 81 517 154 HOH HOH B . Z 9 HOH 82 518 159 HOH HOH B . Z 9 HOH 83 519 160 HOH HOH B . Z 9 HOH 84 520 162 HOH HOH B . Z 9 HOH 85 521 163 HOH HOH B . Z 9 HOH 86 522 166 HOH HOH B . Z 9 HOH 87 523 168 HOH HOH B . Z 9 HOH 88 524 169 HOH HOH B . Z 9 HOH 89 525 171 HOH HOH B . Z 9 HOH 90 526 178 HOH HOH B . Z 9 HOH 91 527 179 HOH HOH B . Z 9 HOH 92 528 181 HOH HOH B . Z 9 HOH 93 529 183 HOH HOH B . Z 9 HOH 94 530 186 HOH HOH B . Z 9 HOH 95 531 192 HOH HOH B . Z 9 HOH 96 532 194 HOH HOH B . Z 9 HOH 97 533 196 HOH HOH B . Z 9 HOH 98 534 197 HOH HOH B . Z 9 HOH 99 535 198 HOH HOH B . Z 9 HOH 100 536 201 HOH HOH B . Z 9 HOH 101 537 202 HOH HOH B . Z 9 HOH 102 538 203 HOH HOH B . Z 9 HOH 103 539 212 HOH HOH B . Z 9 HOH 104 540 213 HOH HOH B . Z 9 HOH 105 541 214 HOH HOH B . Z 9 HOH 106 542 217 HOH HOH B . Z 9 HOH 107 543 223 HOH HOH B . Z 9 HOH 108 544 225 HOH HOH B . Z 9 HOH 109 545 227 HOH HOH B . Z 9 HOH 110 546 229 HOH HOH B . Z 9 HOH 111 547 231 HOH HOH B . Z 9 HOH 112 548 237 HOH HOH B . Z 9 HOH 113 549 239 HOH HOH B . Z 9 HOH 114 550 241 HOH HOH B . Z 9 HOH 115 551 242 HOH HOH B . Z 9 HOH 116 552 243 HOH HOH B . Z 9 HOH 117 553 247 HOH HOH B . Z 9 HOH 118 554 251 HOH HOH B . Z 9 HOH 119 555 253 HOH HOH B . Z 9 HOH 120 556 257 HOH HOH B . Z 9 HOH 121 557 258 HOH HOH B . Z 9 HOH 122 558 259 HOH HOH B . Z 9 HOH 123 559 260 HOH HOH B . Z 9 HOH 124 560 263 HOH HOH B . Z 9 HOH 125 561 265 HOH HOH B . Z 9 HOH 126 562 266 HOH HOH B . Z 9 HOH 127 563 267 HOH HOH B . Z 9 HOH 128 564 270 HOH HOH B . Z 9 HOH 129 565 271 HOH HOH B . Z 9 HOH 130 566 272 HOH HOH B . Z 9 HOH 131 567 273 HOH HOH B . Z 9 HOH 132 568 281 HOH HOH B . Z 9 HOH 133 569 282 HOH HOH B . Z 9 HOH 134 570 283 HOH HOH B . Z 9 HOH 135 571 285 HOH HOH B . Z 9 HOH 136 572 287 HOH HOH B . Z 9 HOH 137 573 290 HOH HOH B . Z 9 HOH 138 574 293 HOH HOH B . Z 9 HOH 139 575 294 HOH HOH B . Z 9 HOH 140 576 298 HOH HOH B . Z 9 HOH 141 577 299 HOH HOH B . Z 9 HOH 142 578 300 HOH HOH B . Z 9 HOH 143 579 304 HOH HOH B . Z 9 HOH 144 580 309 HOH HOH B . Z 9 HOH 145 581 310 HOH HOH B . Z 9 HOH 146 582 314 HOH HOH B . Z 9 HOH 147 583 318 HOH HOH B . Z 9 HOH 148 584 320 HOH HOH B . Z 9 HOH 149 585 321 HOH HOH B . Z 9 HOH 150 586 322 HOH HOH B . # loop_ _pdbx_struct_mod_residue.id _pdbx_struct_mod_residue.label_asym_id _pdbx_struct_mod_residue.label_comp_id _pdbx_struct_mod_residue.label_seq_id _pdbx_struct_mod_residue.auth_asym_id _pdbx_struct_mod_residue.auth_comp_id _pdbx_struct_mod_residue.auth_seq_id _pdbx_struct_mod_residue.PDB_ins_code _pdbx_struct_mod_residue.parent_comp_id _pdbx_struct_mod_residue.details 1 A ASN 215 A ASN 284 ? ASN 'GLYCOSYLATION SITE' 2 B ASN 215 B ASN 284 ? ASN 'GLYCOSYLATION SITE' # loop_ _pdbx_struct_assembly.id _pdbx_struct_assembly.details _pdbx_struct_assembly.method_details _pdbx_struct_assembly.oligomeric_details _pdbx_struct_assembly.oligomeric_count 1 author_and_software_defined_assembly PISA tetrameric 4 2 author_and_software_defined_assembly PISA tetrameric 4 # loop_ _pdbx_struct_assembly_gen.assembly_id _pdbx_struct_assembly_gen.oper_expression _pdbx_struct_assembly_gen.asym_id_list 1 1,2,3,4 A,C,D,E,F,G,H,I,J,K,L,Y 2 1,5,6,7 B,M,N,O,P,Q,R,S,T,U,V,W,X,Z # loop_ _pdbx_struct_assembly_prop.biol_id _pdbx_struct_assembly_prop.type _pdbx_struct_assembly_prop.value _pdbx_struct_assembly_prop.details 1 'ABSA (A^2)' 15430 ? 1 MORE -77 ? 1 'SSA (A^2)' 45800 ? 2 'ABSA (A^2)' 15300 ? 2 MORE -77 ? 2 'SSA (A^2)' 45690 ? # loop_ _pdbx_struct_oper_list.id _pdbx_struct_oper_list.type _pdbx_struct_oper_list.name _pdbx_struct_oper_list.symmetry_operation _pdbx_struct_oper_list.matrix[1][1] _pdbx_struct_oper_list.matrix[1][2] _pdbx_struct_oper_list.matrix[1][3] _pdbx_struct_oper_list.vector[1] _pdbx_struct_oper_list.matrix[2][1] _pdbx_struct_oper_list.matrix[2][2] _pdbx_struct_oper_list.matrix[2][3] _pdbx_struct_oper_list.vector[2] _pdbx_struct_oper_list.matrix[3][1] _pdbx_struct_oper_list.matrix[3][2] _pdbx_struct_oper_list.matrix[3][3] _pdbx_struct_oper_list.vector[3] 1 'identity operation' 1_555 x,y,z 1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 2 'crystal symmetry operation' 2_645 -x+1,-y-1,z -1.0000000000 0.0000000000 0.0000000000 87.6400000000 0.0000000000 -1.0000000000 0.0000000000 -87.6400000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 3 'crystal symmetry operation' 3_545 -y,x-1,z 0.0000000000 -1.0000000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 0.0000000000 -87.6400000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 4 'crystal symmetry operation' 4_655 y+1,-x,z 0.0000000000 1.0000000000 0.0000000000 87.6400000000 -1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 5 'crystal symmetry operation' 2_555 -x,-y,z -1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 6 'crystal symmetry operation' 3_555 -y,x,z 0.0000000000 -1.0000000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 7 'crystal symmetry operation' 4_555 y,-x,z 0.0000000000 1.0000000000 0.0000000000 0.0000000000 -1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 # loop_ _pdbx_struct_special_symmetry.id _pdbx_struct_special_symmetry.PDB_model_num _pdbx_struct_special_symmetry.auth_asym_id _pdbx_struct_special_symmetry.auth_comp_id _pdbx_struct_special_symmetry.auth_seq_id _pdbx_struct_special_symmetry.PDB_ins_code _pdbx_struct_special_symmetry.label_asym_id _pdbx_struct_special_symmetry.label_comp_id _pdbx_struct_special_symmetry.label_seq_id 1 1 A HOH 534 ? Y HOH . 2 1 A HOH 584 ? Y HOH . 3 1 A HOH 598 ? Y HOH . 4 1 A HOH 600 ? Y HOH . 5 1 B HOH 546 ? Z HOH . # loop_ _pdbx_struct_conn_angle.id _pdbx_struct_conn_angle.ptnr1_label_atom_id _pdbx_struct_conn_angle.ptnr1_label_alt_id _pdbx_struct_conn_angle.ptnr1_label_asym_id _pdbx_struct_conn_angle.ptnr1_label_comp_id _pdbx_struct_conn_angle.ptnr1_label_seq_id _pdbx_struct_conn_angle.ptnr1_auth_atom_id _pdbx_struct_conn_angle.ptnr1_auth_asym_id _pdbx_struct_conn_angle.ptnr1_auth_comp_id _pdbx_struct_conn_angle.ptnr1_auth_seq_id _pdbx_struct_conn_angle.ptnr1_PDB_ins_code _pdbx_struct_conn_angle.ptnr1_symmetry _pdbx_struct_conn_angle.ptnr2_label_atom_id _pdbx_struct_conn_angle.ptnr2_label_alt_id _pdbx_struct_conn_angle.ptnr2_label_asym_id _pdbx_struct_conn_angle.ptnr2_label_comp_id _pdbx_struct_conn_angle.ptnr2_label_seq_id _pdbx_struct_conn_angle.ptnr2_auth_atom_id _pdbx_struct_conn_angle.ptnr2_auth_asym_id _pdbx_struct_conn_angle.ptnr2_auth_comp_id _pdbx_struct_conn_angle.ptnr2_auth_seq_id _pdbx_struct_conn_angle.ptnr2_PDB_ins_code _pdbx_struct_conn_angle.ptnr2_symmetry _pdbx_struct_conn_angle.ptnr3_label_atom_id _pdbx_struct_conn_angle.ptnr3_label_alt_id _pdbx_struct_conn_angle.ptnr3_label_asym_id _pdbx_struct_conn_angle.ptnr3_label_comp_id _pdbx_struct_conn_angle.ptnr3_label_seq_id _pdbx_struct_conn_angle.ptnr3_auth_atom_id _pdbx_struct_conn_angle.ptnr3_auth_asym_id _pdbx_struct_conn_angle.ptnr3_auth_comp_id _pdbx_struct_conn_angle.ptnr3_auth_seq_id _pdbx_struct_conn_angle.ptnr3_PDB_ins_code _pdbx_struct_conn_angle.ptnr3_symmetry _pdbx_struct_conn_angle.value _pdbx_struct_conn_angle.value_esd 1 O ? B ASP 224 ? B ASP 293 ? 1_555 CA ? X CA . ? B CA 472 ? 1_555 O ? B GLY 277 ? B GLY 346 ? 1_555 83.7 ? 2 O ? B ASP 224 ? B ASP 293 ? 1_555 CA ? X CA . ? B CA 472 ? 1_555 O ? B GLY 275 ? B GLY 344 ? 1_555 112.9 ? 3 O ? B GLY 277 ? B GLY 346 ? 1_555 CA ? X CA . ? B CA 472 ? 1_555 O ? B GLY 275 ? B GLY 344 ? 1_555 86.2 ? 4 O ? B ASP 224 ? B ASP 293 ? 1_555 CA ? X CA . ? B CA 472 ? 1_555 OD2 ? B ASP 255 ? B ASP 324 ? 1_555 90.3 ? 5 O ? B GLY 277 ? B GLY 346 ? 1_555 CA ? X CA . ? B CA 472 ? 1_555 OD2 ? B ASP 255 ? B ASP 324 ? 1_555 99.2 ? 6 O ? B GLY 275 ? B GLY 344 ? 1_555 CA ? X CA . ? B CA 472 ? 1_555 OD2 ? B ASP 255 ? B ASP 324 ? 1_555 156.7 ? 7 O ? B ASP 224 ? B ASP 293 ? 1_555 CA ? X CA . ? B CA 472 ? 1_555 O ? B THR 228 ? B THR 297 ? 1_555 94.5 ? 8 O ? B GLY 277 ? B GLY 346 ? 1_555 CA ? X CA . ? B CA 472 ? 1_555 O ? B THR 228 ? B THR 297 ? 1_555 163.4 ? 9 O ? B GLY 275 ? B GLY 344 ? 1_555 CA ? X CA . ? B CA 472 ? 1_555 O ? B THR 228 ? B THR 297 ? 1_555 79.4 ? 10 OD2 ? B ASP 255 ? B ASP 324 ? 1_555 CA ? X CA . ? B CA 472 ? 1_555 O ? B THR 228 ? B THR 297 ? 1_555 97.3 ? 11 O ? A GLY 277 ? A GLY 346 ? 1_555 CA ? L CA . ? A CA 470 ? 1_555 O ? A ASP 224 ? A ASP 293 ? 1_555 89.4 ? 12 O ? A GLY 277 ? A GLY 346 ? 1_555 CA ? L CA . ? A CA 470 ? 1_555 O ? A GLY 275 ? A GLY 344 ? 1_555 98.3 ? 13 O ? A ASP 224 ? A ASP 293 ? 1_555 CA ? L CA . ? A CA 470 ? 1_555 O ? A GLY 275 ? A GLY 344 ? 1_555 107.6 ? 14 O ? A GLY 277 ? A GLY 346 ? 1_555 CA ? L CA . ? A CA 470 ? 1_555 O ? A THR 228 ? A THR 297 ? 1_555 170.4 ? 15 O ? A ASP 224 ? A ASP 293 ? 1_555 CA ? L CA . ? A CA 470 ? 1_555 O ? A THR 228 ? A THR 297 ? 1_555 83.7 ? 16 O ? A GLY 275 ? A GLY 344 ? 1_555 CA ? L CA . ? A CA 470 ? 1_555 O ? A THR 228 ? A THR 297 ? 1_555 77.5 ? 17 O ? A GLY 277 ? A GLY 346 ? 1_555 CA ? L CA . ? A CA 470 ? 1_555 OD2 ? A ASP 255 ? A ASP 324 ? 1_555 98.6 ? 18 O ? A ASP 224 ? A ASP 293 ? 1_555 CA ? L CA . ? A CA 470 ? 1_555 OD2 ? A ASP 255 ? A ASP 324 ? 1_555 76.7 ? 19 O ? A GLY 275 ? A GLY 344 ? 1_555 CA ? L CA . ? A CA 470 ? 1_555 OD2 ? A ASP 255 ? A ASP 324 ? 1_555 162.5 ? 20 O ? A THR 228 ? A THR 297 ? 1_555 CA ? L CA . ? A CA 470 ? 1_555 OD2 ? A ASP 255 ? A ASP 324 ? 1_555 86.4 ? 21 O ? A GLY 277 ? A GLY 346 ? 1_555 CA ? L CA . ? A CA 470 ? 1_555 O ? Y HOH . ? A HOH 529 ? 1_555 86.1 ? 22 O ? A ASP 224 ? A ASP 293 ? 1_555 CA ? L CA . ? A CA 470 ? 1_555 O ? Y HOH . ? A HOH 529 ? 1_555 160.5 ? 23 O ? A GLY 275 ? A GLY 344 ? 1_555 CA ? L CA . ? A CA 470 ? 1_555 O ? Y HOH . ? A HOH 529 ? 1_555 91.8 ? 24 O ? A THR 228 ? A THR 297 ? 1_555 CA ? L CA . ? A CA 470 ? 1_555 O ? Y HOH . ? A HOH 529 ? 1_555 102.7 ? 25 OD2 ? A ASP 255 ? A ASP 324 ? 1_555 CA ? L CA . ? A CA 470 ? 1_555 O ? Y HOH . ? A HOH 529 ? 1_555 85.2 ? # loop_ _pdbx_audit_revision_history.ordinal _pdbx_audit_revision_history.data_content_type _pdbx_audit_revision_history.major_revision _pdbx_audit_revision_history.minor_revision _pdbx_audit_revision_history.revision_date 1 'Structure model' 1 0 2010-09-01 2 'Structure model' 1 1 2011-07-13 # _pdbx_audit_revision_details.ordinal 1 _pdbx_audit_revision_details.revision_ordinal 1 _pdbx_audit_revision_details.data_content_type 'Structure model' _pdbx_audit_revision_details.provider repository _pdbx_audit_revision_details.type 'Initial release' _pdbx_audit_revision_details.description ? # _pdbx_audit_revision_group.ordinal 1 _pdbx_audit_revision_group.revision_ordinal 2 _pdbx_audit_revision_group.data_content_type 'Structure model' _pdbx_audit_revision_group.group 'Version format compliance' # loop_ _software.name _software.classification _software.version _software.citation_id _software.pdbx_ordinal Blu-Ice 'data collection' . ? 1 PHENIX 'model building' . ? 2 REFMAC refinement 5.5.0109 ? 3 MOSFLM 'data reduction' . ? 4 SCALA 'data scaling' . ? 5 PHENIX phasing . ? 6 # loop_ _pdbx_validate_close_contact.id _pdbx_validate_close_contact.PDB_model_num _pdbx_validate_close_contact.auth_atom_id_1 _pdbx_validate_close_contact.auth_asym_id_1 _pdbx_validate_close_contact.auth_comp_id_1 _pdbx_validate_close_contact.auth_seq_id_1 _pdbx_validate_close_contact.PDB_ins_code_1 _pdbx_validate_close_contact.label_alt_id_1 _pdbx_validate_close_contact.auth_atom_id_2 _pdbx_validate_close_contact.auth_asym_id_2 _pdbx_validate_close_contact.auth_comp_id_2 _pdbx_validate_close_contact.auth_seq_id_2 _pdbx_validate_close_contact.PDB_ins_code_2 _pdbx_validate_close_contact.label_alt_id_2 _pdbx_validate_close_contact.dist 1 1 O A GLY 108 ? ? O A HOH 571 ? ? 2.08 2 1 O A HOH 495 ? ? O A HOH 594 ? ? 2.15 3 1 O A HOH 38 ? ? O A HOH 518 ? ? 2.16 4 1 OE1 A GLU 250 ? ? O A HOH 558 ? ? 2.17 # _pdbx_validate_rmsd_angle.id 1 _pdbx_validate_rmsd_angle.PDB_model_num 1 _pdbx_validate_rmsd_angle.auth_atom_id_1 CB _pdbx_validate_rmsd_angle.auth_asym_id_1 B _pdbx_validate_rmsd_angle.auth_comp_id_1 ASP _pdbx_validate_rmsd_angle.auth_seq_id_1 463 _pdbx_validate_rmsd_angle.PDB_ins_code_1 ? _pdbx_validate_rmsd_angle.label_alt_id_1 ? _pdbx_validate_rmsd_angle.auth_atom_id_2 CG _pdbx_validate_rmsd_angle.auth_asym_id_2 B _pdbx_validate_rmsd_angle.auth_comp_id_2 ASP _pdbx_validate_rmsd_angle.auth_seq_id_2 463 _pdbx_validate_rmsd_angle.PDB_ins_code_2 ? _pdbx_validate_rmsd_angle.label_alt_id_2 ? _pdbx_validate_rmsd_angle.auth_atom_id_3 OD2 _pdbx_validate_rmsd_angle.auth_asym_id_3 B _pdbx_validate_rmsd_angle.auth_comp_id_3 ASP _pdbx_validate_rmsd_angle.auth_seq_id_3 463 _pdbx_validate_rmsd_angle.PDB_ins_code_3 ? _pdbx_validate_rmsd_angle.label_alt_id_3 ? _pdbx_validate_rmsd_angle.angle_value 124.03 _pdbx_validate_rmsd_angle.angle_target_value 118.30 _pdbx_validate_rmsd_angle.angle_deviation 5.73 _pdbx_validate_rmsd_angle.angle_standard_deviation 0.90 _pdbx_validate_rmsd_angle.linker_flag N # loop_ _pdbx_validate_torsion.id _pdbx_validate_torsion.PDB_model_num _pdbx_validate_torsion.auth_comp_id _pdbx_validate_torsion.auth_asym_id _pdbx_validate_torsion.auth_seq_id _pdbx_validate_torsion.PDB_ins_code _pdbx_validate_torsion.label_alt_id _pdbx_validate_torsion.phi _pdbx_validate_torsion.psi 1 1 SER A 90 ? ? -148.79 12.49 2 1 LEU A 96 ? ? -171.60 126.65 3 1 ALA A 176 ? ? -178.69 140.24 4 1 ASN A 199 ? ? -155.24 61.55 5 1 ASN A 220 ? ? -151.73 72.11 6 1 ILE A 221 ? ? 73.31 62.62 7 1 PRO A 336 ? ? -76.45 -169.18 8 1 LYS A 343 ? ? 27.10 62.09 9 1 LYS A 360 ? ? -170.72 148.74 10 1 MET A 377 ? ? -160.65 113.51 11 1 ASP A 384 ? ? 56.53 -163.62 12 1 TRP A 408 ? ? -103.52 -128.19 13 1 CYS B 182 ? ? -170.79 149.85 14 1 ASN B 199 ? ? -148.39 59.56 15 1 ILE B 221 ? ? 49.07 74.83 16 1 LYS B 343 ? ? 25.59 59.48 17 1 MET B 377 ? ? -162.67 112.51 18 1 ASP B 384 ? ? 54.08 -157.60 19 1 TRP B 408 ? ? -110.95 -129.44 # loop_ _pdbx_validate_peptide_omega.id _pdbx_validate_peptide_omega.PDB_model_num _pdbx_validate_peptide_omega.auth_comp_id_1 _pdbx_validate_peptide_omega.auth_asym_id_1 _pdbx_validate_peptide_omega.auth_seq_id_1 _pdbx_validate_peptide_omega.PDB_ins_code_1 _pdbx_validate_peptide_omega.label_alt_id_1 _pdbx_validate_peptide_omega.auth_comp_id_2 _pdbx_validate_peptide_omega.auth_asym_id_2 _pdbx_validate_peptide_omega.auth_seq_id_2 _pdbx_validate_peptide_omega.PDB_ins_code_2 _pdbx_validate_peptide_omega.label_alt_id_2 _pdbx_validate_peptide_omega.omega 1 1 ASN A 340 ? ? GLY A 341 ? ? -39.65 2 1 ASN B 340 ? ? GLY B 341 ? ? -51.63 # loop_ _pdbx_unobs_or_zero_occ_residues.id _pdbx_unobs_or_zero_occ_residues.PDB_model_num _pdbx_unobs_or_zero_occ_residues.polymer_flag _pdbx_unobs_or_zero_occ_residues.occupancy_flag _pdbx_unobs_or_zero_occ_residues.auth_asym_id _pdbx_unobs_or_zero_occ_residues.auth_comp_id _pdbx_unobs_or_zero_occ_residues.auth_seq_id _pdbx_unobs_or_zero_occ_residues.PDB_ins_code _pdbx_unobs_or_zero_occ_residues.label_asym_id _pdbx_unobs_or_zero_occ_residues.label_comp_id _pdbx_unobs_or_zero_occ_residues.label_seq_id 1 1 Y 1 A GLY 70 ? A GLY 1 2 1 Y 1 A VAL 71 ? A VAL 2 3 1 Y 1 A THR 72 ? A THR 3 4 1 Y 1 A LEU 73 ? A LEU 4 5 1 Y 1 A LEU 74 ? A LEU 5 6 1 Y 1 A LEU 75 ? A LEU 6 7 1 Y 1 A PRO 76 ? A PRO 7 8 1 Y 1 A GLU 77 ? A GLU 8 9 1 Y 1 B GLY 70 ? B GLY 1 10 1 Y 1 B VAL 71 ? B VAL 2 11 1 Y 1 B THR 72 ? B THR 3 12 1 Y 1 B LEU 73 ? B LEU 4 13 1 Y 1 B LEU 74 ? B LEU 5 14 1 Y 1 B LEU 75 ? B LEU 6 15 1 Y 1 B PRO 76 ? B PRO 7 16 1 Y 1 B GLU 77 ? B GLU 8 # loop_ _pdbx_entity_nonpoly.entity_id _pdbx_entity_nonpoly.name _pdbx_entity_nonpoly.comp_id 2 N-ACETYL-D-GLUCOSAMINE NAG 3 BETA-D-MANNOSE BMA 4 ALPHA-D-MANNOSE MAN 5 'SULFATE ION' SO4 6 1,2-ETHANEDIOL EDO 7 GLYCEROL GOL 8 'CALCIUM ION' CA 9 water HOH #