data_3H9Z # _entry.id 3H9Z # _audit_conform.dict_name mmcif_pdbx.dic _audit_conform.dict_version 5.287 _audit_conform.dict_location http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic # loop_ _database_2.database_id _database_2.database_code PDB 3H9Z RCSB RCSB052878 WWPDB D_1000052878 # loop_ _pdbx_database_related.db_name _pdbx_database_related.db_id _pdbx_database_related.details _pdbx_database_related.content_type PDB 1FP5 ;The 'wild-type carbohydrate' form of the same protein (has wild-type N371 and N383). ; unspecified PDB 1F6A ;The 'wild-type carbohydrate' form of the same protein in complex with the alpha chain of the IgE-FcRI. ; unspecified PDB 1O0V 'The structure of the IgE-Fc domains 2-4.' unspecified PDB 3H9Y 'Crystal structure of the IgE-Fc3-4 domains, crystal form 1' unspecified PDB 3HA0 'Crystal structure of the IgE-Fc3-4 domains, crystal form 3' unspecified # _pdbx_database_status.entry_id 3H9Z _pdbx_database_status.status_code REL _pdbx_database_status.deposit_site RCSB _pdbx_database_status.process_site RCSB _pdbx_database_status.recvd_initial_deposition_date 2009-04-30 _pdbx_database_status.status_code_sf REL _pdbx_database_status.status_code_mr ? _pdbx_database_status.SG_entry ? _pdbx_database_status.pdb_format_compatible Y _pdbx_database_status.status_code_cs ? _pdbx_database_status.methods_development_category ? # _audit_author.name 'Wurzburg, B.A.' _audit_author.pdbx_ordinal 1 # _citation.id primary _citation.title 'Conformational flexibility in immunoglobulin E-Fc 3-4 revealed in multiple crystal forms.' _citation.journal_abbrev J.Mol.Biol. _citation.journal_volume 393 _citation.page_first 176 _citation.page_last 190 _citation.year 2009 _citation.journal_id_ASTM JMOBAK _citation.country UK _citation.journal_id_ISSN 0022-2836 _citation.journal_id_CSD 0070 _citation.book_publisher ? _citation.pdbx_database_id_PubMed 19682998 _citation.pdbx_database_id_DOI 10.1016/j.jmb.2009.08.012 # loop_ _citation_author.citation_id _citation_author.name _citation_author.ordinal primary 'Wurzburg, B.A.' 1 primary 'Jardetzky, T.S.' 2 # _cell.entry_id 3H9Z _cell.length_a 65.660 _cell.length_b 99.352 _cell.length_c 77.639 _cell.angle_alpha 90.00 _cell.angle_beta 97.40 _cell.angle_gamma 90.00 _cell.Z_PDB 8 _cell.pdbx_unique_axis ? _cell.length_a_esd ? _cell.length_b_esd ? _cell.length_c_esd ? _cell.angle_alpha_esd ? _cell.angle_beta_esd ? _cell.angle_gamma_esd ? # _symmetry.entry_id 3H9Z _symmetry.space_group_name_H-M 'P 1 21 1' _symmetry.pdbx_full_space_group_name_H-M ? _symmetry.cell_setting ? _symmetry.Int_Tables_number 4 _symmetry.space_group_name_Hall ? # loop_ _entity.id _entity.type _entity.src_method _entity.pdbx_description _entity.formula_weight _entity.pdbx_number_of_molecules _entity.pdbx_ec _entity.pdbx_mutation _entity.pdbx_fragment _entity.details 1 polymer man 'Ig epsilon chain C region' 24920.146 4 ? 'N252Q, N264Q' 'UNP residues 209-428' ? 2 non-polymer man N-ACETYL-D-GLUCOSAMINE 221.208 6 ? ? ? ? 3 non-polymer man BETA-D-MANNOSE 180.156 3 ? ? ? ? 4 non-polymer man ALPHA-D-MANNOSE 180.156 6 ? ? ? ? 5 non-polymer syn 'AMMONIUM ION' 18.038 1 ? ? ? ? 6 water nat water 18.015 146 ? ? ? ? # _entity_poly.entity_id 1 _entity_poly.type 'polypeptide(L)' _entity_poly.nstd_linkage no _entity_poly.nstd_monomer no _entity_poly.pdbx_seq_one_letter_code ;ADPCADSNPRGVSAYLSRPSPFDLFIRKSPTITCLVVDLAPSKGTVQLTWSRASGKPVQHSTRKEEKQRNGTLTVTSTLP VGTRDWIEGETYQCRVTHPHLPRALMRSTTKTSGPRAAPEVYAFATPEWPGSRDKRTLACLIQNFMPEDISVQWLHNEVQ LPDARHSTTQPRKTKGSGFFVFSRLEVTRAEWEQKDEFICRAVHEAASPSQTVQRAVSVNPGK ; _entity_poly.pdbx_seq_one_letter_code_can ;ADPCADSNPRGVSAYLSRPSPFDLFIRKSPTITCLVVDLAPSKGTVQLTWSRASGKPVQHSTRKEEKQRNGTLTVTSTLP VGTRDWIEGETYQCRVTHPHLPRALMRSTTKTSGPRAAPEVYAFATPEWPGSRDKRTLACLIQNFMPEDISVQWLHNEVQ LPDARHSTTQPRKTKGSGFFVFSRLEVTRAEWEQKDEFICRAVHEAASPSQTVQRAVSVNPGK ; _entity_poly.pdbx_strand_id A,B,C,D _entity_poly.pdbx_target_identifier ? # loop_ _entity_poly_seq.entity_id _entity_poly_seq.num _entity_poly_seq.mon_id _entity_poly_seq.hetero 1 1 ALA n 1 2 ASP n 1 3 PRO n 1 4 CYS n 1 5 ALA n 1 6 ASP n 1 7 SER n 1 8 ASN n 1 9 PRO n 1 10 ARG n 1 11 GLY n 1 12 VAL n 1 13 SER n 1 14 ALA n 1 15 TYR n 1 16 LEU n 1 17 SER n 1 18 ARG n 1 19 PRO n 1 20 SER n 1 21 PRO n 1 22 PHE n 1 23 ASP n 1 24 LEU n 1 25 PHE n 1 26 ILE n 1 27 ARG n 1 28 LYS n 1 29 SER n 1 30 PRO n 1 31 THR n 1 32 ILE n 1 33 THR n 1 34 CYS n 1 35 LEU n 1 36 VAL n 1 37 VAL n 1 38 ASP n 1 39 LEU n 1 40 ALA n 1 41 PRO n 1 42 SER n 1 43 LYS n 1 44 GLY n 1 45 THR n 1 46 VAL n 1 47 GLN n 1 48 LEU n 1 49 THR n 1 50 TRP n 1 51 SER n 1 52 ARG n 1 53 ALA n 1 54 SER n 1 55 GLY n 1 56 LYS n 1 57 PRO n 1 58 VAL n 1 59 GLN n 1 60 HIS n 1 61 SER n 1 62 THR n 1 63 ARG n 1 64 LYS n 1 65 GLU n 1 66 GLU n 1 67 LYS n 1 68 GLN n 1 69 ARG n 1 70 ASN n 1 71 GLY n 1 72 THR n 1 73 LEU n 1 74 THR n 1 75 VAL n 1 76 THR n 1 77 SER n 1 78 THR n 1 79 LEU n 1 80 PRO n 1 81 VAL n 1 82 GLY n 1 83 THR n 1 84 ARG n 1 85 ASP n 1 86 TRP n 1 87 ILE n 1 88 GLU n 1 89 GLY n 1 90 GLU n 1 91 THR n 1 92 TYR n 1 93 GLN n 1 94 CYS n 1 95 ARG n 1 96 VAL n 1 97 THR n 1 98 HIS n 1 99 PRO n 1 100 HIS n 1 101 LEU n 1 102 PRO n 1 103 ARG n 1 104 ALA n 1 105 LEU n 1 106 MET n 1 107 ARG n 1 108 SER n 1 109 THR n 1 110 THR n 1 111 LYS n 1 112 THR n 1 113 SER n 1 114 GLY n 1 115 PRO n 1 116 ARG n 1 117 ALA n 1 118 ALA n 1 119 PRO n 1 120 GLU n 1 121 VAL n 1 122 TYR n 1 123 ALA n 1 124 PHE n 1 125 ALA n 1 126 THR n 1 127 PRO n 1 128 GLU n 1 129 TRP n 1 130 PRO n 1 131 GLY n 1 132 SER n 1 133 ARG n 1 134 ASP n 1 135 LYS n 1 136 ARG n 1 137 THR n 1 138 LEU n 1 139 ALA n 1 140 CYS n 1 141 LEU n 1 142 ILE n 1 143 GLN n 1 144 ASN n 1 145 PHE n 1 146 MET n 1 147 PRO n 1 148 GLU n 1 149 ASP n 1 150 ILE n 1 151 SER n 1 152 VAL n 1 153 GLN n 1 154 TRP n 1 155 LEU n 1 156 HIS n 1 157 ASN n 1 158 GLU n 1 159 VAL n 1 160 GLN n 1 161 LEU n 1 162 PRO n 1 163 ASP n 1 164 ALA n 1 165 ARG n 1 166 HIS n 1 167 SER n 1 168 THR n 1 169 THR n 1 170 GLN n 1 171 PRO n 1 172 ARG n 1 173 LYS n 1 174 THR n 1 175 LYS n 1 176 GLY n 1 177 SER n 1 178 GLY n 1 179 PHE n 1 180 PHE n 1 181 VAL n 1 182 PHE n 1 183 SER n 1 184 ARG n 1 185 LEU n 1 186 GLU n 1 187 VAL n 1 188 THR n 1 189 ARG n 1 190 ALA n 1 191 GLU n 1 192 TRP n 1 193 GLU n 1 194 GLN n 1 195 LYS n 1 196 ASP n 1 197 GLU n 1 198 PHE n 1 199 ILE n 1 200 CYS n 1 201 ARG n 1 202 ALA n 1 203 VAL n 1 204 HIS n 1 205 GLU n 1 206 ALA n 1 207 ALA n 1 208 SER n 1 209 PRO n 1 210 SER n 1 211 GLN n 1 212 THR n 1 213 VAL n 1 214 GLN n 1 215 ARG n 1 216 ALA n 1 217 VAL n 1 218 SER n 1 219 VAL n 1 220 ASN n 1 221 PRO n 1 222 GLY n 1 223 LYS n # _entity_src_gen.entity_id 1 _entity_src_gen.pdbx_src_id 1 _entity_src_gen.pdbx_alt_source_flag sample _entity_src_gen.pdbx_seq_type ? _entity_src_gen.pdbx_beg_seq_num ? _entity_src_gen.pdbx_end_seq_num ? _entity_src_gen.gene_src_common_name human _entity_src_gen.gene_src_genus ? _entity_src_gen.pdbx_gene_src_gene IGHE _entity_src_gen.gene_src_species ? _entity_src_gen.gene_src_strain ? _entity_src_gen.gene_src_tissue ? _entity_src_gen.gene_src_tissue_fraction ? _entity_src_gen.gene_src_details ? _entity_src_gen.pdbx_gene_src_fragment ? _entity_src_gen.pdbx_gene_src_scientific_name 'Homo sapiens' _entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 9606 _entity_src_gen.pdbx_gene_src_variant ? _entity_src_gen.pdbx_gene_src_cell_line ? _entity_src_gen.pdbx_gene_src_atcc ? _entity_src_gen.pdbx_gene_src_organ ? _entity_src_gen.pdbx_gene_src_organelle ? _entity_src_gen.pdbx_gene_src_cell ? _entity_src_gen.pdbx_gene_src_cellular_location ? _entity_src_gen.host_org_common_name ? _entity_src_gen.pdbx_host_org_scientific_name 'Trichoplusia ni' _entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 7111 _entity_src_gen.host_org_genus ? _entity_src_gen.pdbx_host_org_gene ? _entity_src_gen.pdbx_host_org_organ ? _entity_src_gen.host_org_species ? _entity_src_gen.pdbx_host_org_tissue ? _entity_src_gen.pdbx_host_org_tissue_fraction ? _entity_src_gen.pdbx_host_org_strain Hi5 _entity_src_gen.pdbx_host_org_variant ? _entity_src_gen.pdbx_host_org_cell_line ? _entity_src_gen.pdbx_host_org_atcc ? _entity_src_gen.pdbx_host_org_culture_collection ? _entity_src_gen.pdbx_host_org_cell ? _entity_src_gen.pdbx_host_org_organelle ? _entity_src_gen.pdbx_host_org_cellular_location ? _entity_src_gen.pdbx_host_org_vector_type plasmid _entity_src_gen.pdbx_host_org_vector 'recombinant baculovirus' _entity_src_gen.host_org_details ? _entity_src_gen.expression_system_id ? _entity_src_gen.plasmid_name pAcGP67A _entity_src_gen.plasmid_details ? _entity_src_gen.pdbx_description ? # _struct_ref.id 1 _struct_ref.db_name UNP _struct_ref.db_code IGHE_HUMAN _struct_ref.pdbx_db_accession P01854 _struct_ref.entity_id 1 _struct_ref.pdbx_seq_one_letter_code ;CADSNPRGVSAYLSRPSPFDLFIRKSPTITCLVVDLAPSKGTVNLTWSRASGKPVNHSTRKEEKQRNGTLTVTSTLPVGT RDWIEGETYQCRVTHPHLPRALMRSTTKTSGPRAAPEVYAFATPEWPGSRDKRTLACLIQNFMPEDISVQWLHNEVQLPD ARHSTTQPRKTKGSGFFVFSRLEVTRAEWEQKDEFICRAVHEAASPSQTVQRAVSVNPGK ; _struct_ref.pdbx_align_begin 209 _struct_ref.pdbx_db_isoform ? # loop_ _struct_ref_seq.align_id _struct_ref_seq.ref_id _struct_ref_seq.pdbx_PDB_id_code _struct_ref_seq.pdbx_strand_id _struct_ref_seq.seq_align_beg _struct_ref_seq.pdbx_seq_align_beg_ins_code _struct_ref_seq.seq_align_end _struct_ref_seq.pdbx_seq_align_end_ins_code _struct_ref_seq.pdbx_db_accession _struct_ref_seq.db_align_beg _struct_ref_seq.pdbx_db_align_beg_ins_code _struct_ref_seq.db_align_end _struct_ref_seq.pdbx_db_align_end_ins_code _struct_ref_seq.pdbx_auth_seq_align_beg _struct_ref_seq.pdbx_auth_seq_align_end 1 1 3H9Z A 4 ? 223 ? P01854 209 ? 428 ? 328 547 2 1 3H9Z B 4 ? 223 ? P01854 209 ? 428 ? 328 547 3 1 3H9Z C 4 ? 223 ? P01854 209 ? 428 ? 328 547 4 1 3H9Z D 4 ? 223 ? P01854 209 ? 428 ? 328 547 # loop_ _struct_ref_seq_dif.align_id _struct_ref_seq_dif.pdbx_pdb_id_code _struct_ref_seq_dif.mon_id _struct_ref_seq_dif.pdbx_pdb_strand_id _struct_ref_seq_dif.seq_num _struct_ref_seq_dif.pdbx_pdb_ins_code _struct_ref_seq_dif.pdbx_seq_db_name _struct_ref_seq_dif.pdbx_seq_db_accession_code _struct_ref_seq_dif.db_mon_id _struct_ref_seq_dif.pdbx_seq_db_seq_num _struct_ref_seq_dif.details _struct_ref_seq_dif.pdbx_auth_seq_num _struct_ref_seq_dif.pdbx_ordinal 1 3H9Z ALA A 1 ? UNP P01854 ? ? 'EXPRESSION TAG' 325 1 1 3H9Z ASP A 2 ? UNP P01854 ? ? 'EXPRESSION TAG' 326 2 1 3H9Z PRO A 3 ? UNP P01854 ? ? 'EXPRESSION TAG' 327 3 1 3H9Z GLN A 47 ? UNP P01854 ASN 252 ENGINEERED 371 4 1 3H9Z GLN A 59 ? UNP P01854 ASN 264 ENGINEERED 383 5 2 3H9Z ALA B 1 ? UNP P01854 ? ? 'EXPRESSION TAG' 325 6 2 3H9Z ASP B 2 ? UNP P01854 ? ? 'EXPRESSION TAG' 326 7 2 3H9Z PRO B 3 ? UNP P01854 ? ? 'EXPRESSION TAG' 327 8 2 3H9Z GLN B 47 ? UNP P01854 ASN 252 ENGINEERED 371 9 2 3H9Z GLN B 59 ? UNP P01854 ASN 264 ENGINEERED 383 10 3 3H9Z ALA C 1 ? UNP P01854 ? ? 'EXPRESSION TAG' 325 11 3 3H9Z ASP C 2 ? UNP P01854 ? ? 'EXPRESSION TAG' 326 12 3 3H9Z PRO C 3 ? UNP P01854 ? ? 'EXPRESSION TAG' 327 13 3 3H9Z GLN C 47 ? UNP P01854 ASN 252 ENGINEERED 371 14 3 3H9Z GLN C 59 ? UNP P01854 ASN 264 ENGINEERED 383 15 4 3H9Z ALA D 1 ? UNP P01854 ? ? 'EXPRESSION TAG' 325 16 4 3H9Z ASP D 2 ? UNP P01854 ? ? 'EXPRESSION TAG' 326 17 4 3H9Z PRO D 3 ? UNP P01854 ? ? 'EXPRESSION TAG' 327 18 4 3H9Z GLN D 47 ? UNP P01854 ASN 252 ENGINEERED 371 19 4 3H9Z GLN D 59 ? UNP P01854 ASN 264 ENGINEERED 383 20 # loop_ _chem_comp.id _chem_comp.type _chem_comp.mon_nstd_flag _chem_comp.name _chem_comp.pdbx_synonyms _chem_comp.formula _chem_comp.formula_weight ALA 'L-peptide linking' y ALANINE ? 'C3 H7 N O2' 89.093 ARG 'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1' 175.209 ASN 'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3' 132.118 ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4' 133.103 BMA D-saccharide . BETA-D-MANNOSE ? 'C6 H12 O6' 180.156 CYS 'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S' 121.158 GLN 'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3' 146.144 GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4' 147.129 GLY 'peptide linking' y GLYCINE ? 'C2 H5 N O2' 75.067 HIS 'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1' 156.162 HOH non-polymer . WATER ? 'H2 O' 18.015 ILE 'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2' 131.173 LEU 'L-peptide linking' y LEUCINE ? 'C6 H13 N O2' 131.173 LYS 'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1' 147.195 MAN D-saccharide . ALPHA-D-MANNOSE ? 'C6 H12 O6' 180.156 MET 'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S' 149.211 NAG D-saccharide . N-ACETYL-D-GLUCOSAMINE ? 'C8 H15 N O6' 221.208 NH4 non-polymer . 'AMMONIUM ION' ? 'H4 N 1' 18.038 PHE 'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2' 165.189 PRO 'L-peptide linking' y PROLINE ? 'C5 H9 N O2' 115.130 SER 'L-peptide linking' y SERINE ? 'C3 H7 N O3' 105.093 THR 'L-peptide linking' y THREONINE ? 'C4 H9 N O3' 119.119 TRP 'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2' 204.225 TYR 'L-peptide linking' y TYROSINE ? 'C9 H11 N O3' 181.189 VAL 'L-peptide linking' y VALINE ? 'C5 H11 N O2' 117.146 # _exptl.entry_id 3H9Z _exptl.method 'X-RAY DIFFRACTION' _exptl.crystals_number 1 # _exptl_crystal.id 1 _exptl_crystal.density_meas ? _exptl_crystal.density_Matthews 2.52 _exptl_crystal.density_percent_sol 51.18 _exptl_crystal.description ? _exptl_crystal.F_000 ? _exptl_crystal.preparation ? # _exptl_crystal_grow.crystal_id 1 _exptl_crystal_grow.method 'VAPOR DIFFUSION, HANGING DROP' _exptl_crystal_grow.temp 293 _exptl_crystal_grow.temp_details ? _exptl_crystal_grow.pH 5.3 _exptl_crystal_grow.pdbx_pH_range ? _exptl_crystal_grow.pdbx_details ;1 microliter of protein at 10 mg/mL in 20 mM sodium chloride was added to 1 microliter of well solution (100 mM ammonium acetate, 100 mM sodium acetate pH 4.6, 30% (w/v) PEG 4000) and mixed by pipetting., VAPOR DIFFUSION, HANGING DROP, temperature 293K ; # _diffrn.id 1 _diffrn.ambient_temp 113.0 _diffrn.ambient_temp_details ? _diffrn.crystal_id 1 # _diffrn_detector.diffrn_id 1 _diffrn_detector.detector CCD _diffrn_detector.type 'MAR CCD 130 mm' _diffrn_detector.pdbx_collection_date 1999-08-07 _diffrn_detector.details ? # _diffrn_radiation.diffrn_id 1 _diffrn_radiation.wavelength_id 1 _diffrn_radiation.pdbx_monochromatic_or_laue_m_l M _diffrn_radiation.monochromator 'Si(111)' _diffrn_radiation.pdbx_diffrn_protocol 'SINGLE WAVELENGTH' _diffrn_radiation.pdbx_scattering_type x-ray # _diffrn_radiation_wavelength.id 1 _diffrn_radiation_wavelength.wavelength 1.0001 _diffrn_radiation_wavelength.wt 1.0 # _diffrn_source.diffrn_id 1 _diffrn_source.source SYNCHROTRON _diffrn_source.type 'APS BEAMLINE 5ID-B' _diffrn_source.pdbx_synchrotron_site APS _diffrn_source.pdbx_synchrotron_beamline 5ID-B _diffrn_source.pdbx_wavelength ? _diffrn_source.pdbx_wavelength_list 1.0001 # _reflns.entry_id 3H9Z _reflns.observed_criterion_sigma_I 0 _reflns.observed_criterion_sigma_F 0 _reflns.d_resolution_low 30.000 _reflns.d_resolution_high 2.450 _reflns.number_obs 36017 _reflns.number_all 36017 _reflns.percent_possible_obs 98.200 _reflns.pdbx_Rmerge_I_obs ? _reflns.pdbx_Rsym_value 0.059 _reflns.pdbx_netI_over_sigmaI 18.425 _reflns.B_iso_Wilson_estimate ? _reflns.pdbx_redundancy 3.63 _reflns.R_free_details ? _reflns.limit_h_max ? _reflns.limit_h_min ? _reflns.limit_k_max ? _reflns.limit_k_min ? _reflns.limit_l_max ? _reflns.limit_l_min ? _reflns.observed_criterion_F_max ? _reflns.observed_criterion_F_min ? _reflns.pdbx_chi_squared ? _reflns.pdbx_scaling_rejects ? _reflns.pdbx_ordinal 1 _reflns.pdbx_diffrn_id 1 # _reflns_shell.d_res_high 2.45 _reflns_shell.d_res_low 2.54 _reflns_shell.percent_possible_all 82.30 _reflns_shell.Rmerge_I_obs ? _reflns_shell.pdbx_Rsym_value 0.241 _reflns_shell.meanI_over_sigI_obs ? _reflns_shell.pdbx_redundancy 2.28 _reflns_shell.percent_possible_obs ? _reflns_shell.number_unique_all ? _reflns_shell.number_measured_all ? _reflns_shell.number_measured_obs ? _reflns_shell.number_unique_obs ? _reflns_shell.pdbx_chi_squared ? _reflns_shell.pdbx_ordinal 1 _reflns_shell.pdbx_diffrn_id 1 # _refine.pdbx_refine_id 'X-RAY DIFFRACTION' _refine.entry_id 3H9Z _refine.ls_number_reflns_obs 35946 _refine.ls_number_reflns_all 35946 _refine.pdbx_ls_sigma_I ? _refine.pdbx_ls_sigma_F 0.000 _refine.pdbx_data_cutoff_high_absF ? _refine.pdbx_data_cutoff_low_absF ? _refine.pdbx_data_cutoff_high_rms_absF ? _refine.ls_d_res_low 28.71 _refine.ls_d_res_high 2.45 _refine.ls_percent_reflns_obs 98.75 _refine.ls_R_factor_obs 0.23182 _refine.ls_R_factor_all ? _refine.ls_R_factor_R_work 0.22936 _refine.ls_R_factor_R_free 0.27748 _refine.ls_R_factor_R_free_error ? _refine.ls_R_factor_R_free_error_details ? _refine.ls_percent_reflns_R_free 5.1 _refine.ls_number_reflns_R_free 1824 _refine.ls_number_parameters ? _refine.ls_number_restraints ? _refine.occupancy_min 1.00 _refine.occupancy_max 1.00 _refine.correlation_coeff_Fo_to_Fc 0.925 _refine.correlation_coeff_Fo_to_Fc_free 0.890 _refine.B_iso_mean 31.781 _refine.aniso_B[1][1] 0.57 _refine.aniso_B[2][2] 0.55 _refine.aniso_B[3][3] -1.06 _refine.aniso_B[1][2] 0.00 _refine.aniso_B[1][3] 0.21 _refine.aniso_B[2][3] 0.00 _refine.solvent_model_details MASK _refine.solvent_model_param_ksol ? _refine.solvent_model_param_bsol ? _refine.pdbx_solvent_vdw_probe_radii 1.40 _refine.pdbx_solvent_ion_probe_radii 0.80 _refine.pdbx_solvent_shrinkage_radii 0.80 _refine.pdbx_ls_cross_valid_method THROUGHOUT _refine.details 'HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS' _refine.pdbx_starting_model 'PDB entry 1FP5' _refine.pdbx_method_to_determine_struct 'MOLECULAR REPLACEMENT' _refine.pdbx_isotropic_thermal_model ? _refine.pdbx_stereochemistry_target_values 'MAXIMUM LIKELIHOOD' _refine.pdbx_stereochem_target_val_spec_case ? _refine.pdbx_R_Free_selection_details RANDOM _refine.pdbx_overall_ESU_R 0.619 _refine.pdbx_overall_ESU_R_Free 0.315 _refine.overall_SU_ML 0.227 _refine.pdbx_overall_phase_error ? _refine.overall_SU_B 20.504 _refine.ls_redundancy_reflns_obs ? _refine.B_iso_min ? _refine.B_iso_max ? _refine.overall_SU_R_Cruickshank_DPI ? _refine.overall_SU_R_free ? _refine.ls_wR_factor_R_free ? _refine.ls_wR_factor_R_work ? _refine.overall_FOM_free_R_set ? _refine.overall_FOM_work_R_set ? _refine.pdbx_TLS_residual_ADP_flag 'LIKELY RESIDUAL' _refine.pdbx_diffrn_id 1 _refine.pdbx_overall_SU_R_free_Cruickshank_DPI ? _refine.pdbx_overall_SU_R_Blow_DPI ? _refine.pdbx_overall_SU_R_free_Blow_DPI ? # _refine_hist.pdbx_refine_id 'X-RAY DIFFRACTION' _refine_hist.cycle_id LAST _refine_hist.pdbx_number_atoms_protein 6624 _refine_hist.pdbx_number_atoms_nucleic_acid 0 _refine_hist.pdbx_number_atoms_ligand 184 _refine_hist.number_atoms_solvent 146 _refine_hist.number_atoms_total 6954 _refine_hist.d_res_high 2.45 _refine_hist.d_res_low 28.71 # loop_ _refine_ls_restr.type _refine_ls_restr.dev_ideal _refine_ls_restr.dev_ideal_target _refine_ls_restr.weight _refine_ls_restr.number _refine_ls_restr.pdbx_refine_id _refine_ls_restr.pdbx_restraint_function r_bond_refined_d 0.010 0.022 ? 7068 'X-RAY DIFFRACTION' ? r_bond_other_d 0.001 0.020 ? 4938 'X-RAY DIFFRACTION' ? r_angle_refined_deg 1.448 1.988 ? 9656 'X-RAY DIFFRACTION' ? r_angle_other_deg 0.746 3.003 ? 11882 'X-RAY DIFFRACTION' ? r_dihedral_angle_1_deg 6.204 5.000 ? 832 'X-RAY DIFFRACTION' ? r_dihedral_angle_2_deg 28.000 22.267 ? 300 'X-RAY DIFFRACTION' ? r_dihedral_angle_3_deg 14.975 15.000 ? 1132 'X-RAY DIFFRACTION' ? r_dihedral_angle_4_deg 15.758 15.000 ? 72 'X-RAY DIFFRACTION' ? r_chiral_restr 0.083 0.200 ? 1132 'X-RAY DIFFRACTION' ? r_gen_planes_refined 0.004 0.021 ? 7608 'X-RAY DIFFRACTION' ? r_gen_planes_other 0.000 0.020 ? 1412 'X-RAY DIFFRACTION' ? r_nbd_refined ? ? ? ? 'X-RAY DIFFRACTION' ? r_nbd_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_nbtor_refined ? ? ? ? 'X-RAY DIFFRACTION' ? r_nbtor_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_xyhbond_nbd_refined ? ? ? ? 'X-RAY DIFFRACTION' ? r_xyhbond_nbd_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_metal_ion_refined ? ? ? ? 'X-RAY DIFFRACTION' ? r_metal_ion_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_symmetry_vdw_refined ? ? ? ? 'X-RAY DIFFRACTION' ? r_symmetry_vdw_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_symmetry_hbond_refined ? ? ? ? 'X-RAY DIFFRACTION' ? r_symmetry_hbond_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_symmetry_metal_ion_refined ? ? ? ? 'X-RAY DIFFRACTION' ? r_symmetry_metal_ion_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_mcbond_it 1.522 2.000 ? 4208 'X-RAY DIFFRACTION' ? r_mcbond_other 0.277 2.000 ? 1640 'X-RAY DIFFRACTION' ? r_mcangle_it 2.569 3.000 ? 6888 'X-RAY DIFFRACTION' ? r_scbond_it 1.396 2.000 ? 2860 'X-RAY DIFFRACTION' ? r_scangle_it 2.179 3.000 ? 2768 'X-RAY DIFFRACTION' ? r_rigid_bond_restr ? ? ? ? 'X-RAY DIFFRACTION' ? r_sphericity_free ? ? ? ? 'X-RAY DIFFRACTION' ? r_sphericity_bonded ? ? ? ? 'X-RAY DIFFRACTION' ? # _refine_ls_shell.pdbx_refine_id 'X-RAY DIFFRACTION' _refine_ls_shell.pdbx_total_number_of_bins_used 10 _refine_ls_shell.d_res_high 2.450 _refine_ls_shell.d_res_low 2.582 _refine_ls_shell.number_reflns_R_work 4598 _refine_ls_shell.R_factor_R_work 0.326 _refine_ls_shell.percent_reflns_obs 91.61 _refine_ls_shell.R_factor_R_free 0.395 _refine_ls_shell.R_factor_R_free_error ? _refine_ls_shell.percent_reflns_R_free ? _refine_ls_shell.number_reflns_R_free 226 _refine_ls_shell.number_reflns_all ? _refine_ls_shell.R_factor_all ? _refine_ls_shell.redundancy_reflns_obs ? _refine_ls_shell.number_reflns_obs ? # _struct.entry_id 3H9Z _struct.title 'Crystal structure of the IgE-Fc3-4 domains' _struct.pdbx_descriptor 'Ig epsilon chain C region' _struct.pdbx_model_details ? _struct.pdbx_CASP_flag ? _struct.pdbx_model_type_details ? # _struct_keywords.entry_id 3H9Z _struct_keywords.text ;Immunoglobin, IgE, Fc, flexibility, hydrophobic pocket, Disulfide bond, Glycoprotein, Immunoglobulin C region, Immunoglobulin domain, IMMUNE SYSTEM ; _struct_keywords.pdbx_keywords 'IMMUNE SYSTEM' # loop_ _struct_asym.id _struct_asym.pdbx_blank_PDB_chainid_flag _struct_asym.pdbx_modified _struct_asym.entity_id _struct_asym.details A N N 1 ? B N N 1 ? C N N 1 ? D N N 1 ? E N N 2 ? F N N 2 ? G N N 3 ? H N N 4 ? I N N 4 ? J N N 2 ? K N N 2 ? L N N 3 ? M N N 4 ? N N N 4 ? O N N 5 ? P N N 2 ? Q N N 2 ? R N N 3 ? S N N 4 ? T N N 4 ? U N N 6 ? V N N 6 ? W N N 6 ? X N N 6 ? # _struct_biol.id 1 _struct_biol.details 'THE BIOLOGICAL UNIT IS A DIMER. THE ASYMMETRIC UNIT CONTAINS 2 DIMERS (CHAINS A:B AND CHAINS C:D).' # loop_ _struct_conf.conf_type_id _struct_conf.id _struct_conf.pdbx_PDB_helix_id _struct_conf.beg_label_comp_id _struct_conf.beg_label_asym_id _struct_conf.beg_label_seq_id _struct_conf.pdbx_beg_PDB_ins_code _struct_conf.end_label_comp_id _struct_conf.end_label_asym_id _struct_conf.end_label_seq_id _struct_conf.pdbx_end_PDB_ins_code _struct_conf.beg_auth_comp_id _struct_conf.beg_auth_asym_id _struct_conf.beg_auth_seq_id _struct_conf.end_auth_comp_id _struct_conf.end_auth_asym_id _struct_conf.end_auth_seq_id _struct_conf.pdbx_PDB_helix_class _struct_conf.details _struct_conf.pdbx_PDB_helix_length HELX_P HELX_P1 1 SER A 20 ? ILE A 26 ? SER A 344 ILE A 350 1 ? 7 HELX_P HELX_P2 2 GLY A 82 ? GLU A 88 ? GLY A 406 GLU A 412 1 ? 7 HELX_P HELX_P3 3 PRO A 162 ? ALA A 164 ? PRO A 486 ALA A 488 5 ? 3 HELX_P HELX_P4 4 ARG A 189 ? LYS A 195 ? ARG A 513 LYS A 519 1 ? 7 HELX_P HELX_P5 5 SER B 20 ? ILE B 26 ? SER B 344 ILE B 350 1 ? 7 HELX_P HELX_P6 6 GLY B 82 ? GLU B 88 ? GLY B 406 GLU B 412 1 ? 7 HELX_P HELX_P7 7 PRO B 162 ? ALA B 164 ? PRO B 486 ALA B 488 5 ? 3 HELX_P HELX_P8 8 ARG B 189 ? LYS B 195 ? ARG B 513 LYS B 519 1 ? 7 HELX_P HELX_P9 9 SER C 20 ? ILE C 26 ? SER C 344 ILE C 350 1 ? 7 HELX_P HELX_P10 10 GLY C 82 ? GLY C 89 ? GLY C 406 GLY C 413 1 ? 8 HELX_P HELX_P11 11 PRO C 162 ? ALA C 164 ? PRO C 486 ALA C 488 5 ? 3 HELX_P HELX_P12 12 ARG C 189 ? LYS C 195 ? ARG C 513 LYS C 519 1 ? 7 HELX_P HELX_P13 13 SER D 20 ? ILE D 26 ? SER D 344 ILE D 350 1 ? 7 HELX_P HELX_P14 14 GLY D 82 ? GLU D 88 ? GLY D 406 GLU D 412 1 ? 7 HELX_P HELX_P15 15 PRO D 162 ? ALA D 164 ? PRO D 486 ALA D 488 5 ? 3 HELX_P HELX_P16 16 ARG D 189 ? LYS D 195 ? ARG D 513 LYS D 519 1 ? 7 # _struct_conf_type.id HELX_P _struct_conf_type.criteria ? _struct_conf_type.reference ? # loop_ _struct_conn.id _struct_conn.conn_type_id _struct_conn.pdbx_leaving_atom_flag _struct_conn.pdbx_PDB_id _struct_conn.ptnr1_label_asym_id _struct_conn.ptnr1_label_comp_id _struct_conn.ptnr1_label_seq_id _struct_conn.ptnr1_label_atom_id _struct_conn.pdbx_ptnr1_label_alt_id _struct_conn.pdbx_ptnr1_PDB_ins_code _struct_conn.pdbx_ptnr1_standard_comp_id _struct_conn.ptnr1_symmetry _struct_conn.ptnr2_label_asym_id _struct_conn.ptnr2_label_comp_id _struct_conn.ptnr2_label_seq_id _struct_conn.ptnr2_label_atom_id _struct_conn.pdbx_ptnr2_label_alt_id _struct_conn.pdbx_ptnr2_PDB_ins_code _struct_conn.ptnr1_auth_asym_id _struct_conn.ptnr1_auth_comp_id _struct_conn.ptnr1_auth_seq_id _struct_conn.ptnr2_auth_asym_id _struct_conn.ptnr2_auth_comp_id _struct_conn.ptnr2_auth_seq_id _struct_conn.ptnr2_symmetry _struct_conn.pdbx_ptnr3_label_atom_id _struct_conn.pdbx_ptnr3_label_seq_id _struct_conn.pdbx_ptnr3_label_comp_id _struct_conn.pdbx_ptnr3_label_asym_id _struct_conn.pdbx_ptnr3_label_alt_id _struct_conn.pdbx_ptnr3_PDB_ins_code _struct_conn.details _struct_conn.pdbx_dist_value _struct_conn.pdbx_value_order disulf1 disulf ? ? A CYS 34 SG ? ? ? 1_555 A CYS 94 SG ? ? A CYS 358 A CYS 418 1_555 ? ? ? ? ? ? ? 2.044 ? disulf2 disulf ? ? A CYS 140 SG ? ? ? 1_555 A CYS 200 SG ? ? A CYS 464 A CYS 524 1_555 ? ? ? ? ? ? ? 2.056 ? disulf3 disulf ? ? B CYS 34 SG ? ? ? 1_555 B CYS 94 SG ? ? B CYS 358 B CYS 418 1_555 ? ? ? ? ? ? ? 2.039 ? disulf4 disulf ? ? B CYS 140 SG ? ? ? 1_555 B CYS 200 SG ? ? B CYS 464 B CYS 524 1_555 ? ? ? ? ? ? ? 2.059 ? disulf5 disulf ? ? C CYS 34 SG ? ? ? 1_555 C CYS 94 SG ? ? C CYS 358 C CYS 418 1_555 ? ? ? ? ? ? ? 2.054 ? disulf6 disulf ? ? C CYS 140 SG ? ? ? 1_555 C CYS 200 SG ? ? C CYS 464 C CYS 524 1_555 ? ? ? ? ? ? ? 2.045 ? disulf7 disulf ? ? D CYS 34 SG ? ? ? 1_555 D CYS 94 SG ? ? D CYS 358 D CYS 418 1_555 ? ? ? ? ? ? ? 2.043 ? disulf8 disulf ? ? D CYS 140 SG ? ? ? 1_555 D CYS 200 SG ? ? D CYS 464 D CYS 524 1_555 ? ? ? ? ? ? ? 2.067 ? covale1 covale ? ? B ASN 70 ND2 ? ? ? 1_555 E NAG . C1 ? ? B ASN 394 B NAG 1 1_555 ? ? ? ? ? ? ? 1.445 ? covale2 covale ? ? C ASN 70 ND2 ? ? ? 1_555 J NAG . C1 ? ? C ASN 394 C NAG 1 1_555 ? ? ? ? ? ? ? 1.449 ? covale3 covale ? ? D ASN 70 ND2 ? ? ? 1_555 P NAG . C1 ? ? D ASN 394 D NAG 1 1_555 ? ? ? ? ? ? ? 1.447 ? covale4 covale ? ? E NAG . O4 ? ? ? 1_555 F NAG . C1 ? ? B NAG 1 B NAG 2 1_555 ? ? ? ? ? ? ? 1.433 ? covale5 covale ? ? F NAG . O4 ? ? ? 1_555 G BMA . C1 ? ? B NAG 2 B BMA 3 1_555 ? ? ? ? ? ? ? 1.438 ? covale6 covale ? ? G BMA . O3 ? ? ? 1_555 I MAN . C1 ? ? B BMA 3 B MAN 5 1_555 ? ? ? ? ? ? ? 1.437 ? covale7 covale ? ? G BMA . O6 ? ? ? 1_555 H MAN . C1 ? ? B BMA 3 B MAN 4 1_555 ? ? ? ? ? ? ? 1.449 ? covale8 covale ? ? J NAG . O4 ? ? ? 1_555 K NAG . C1 ? ? C NAG 1 C NAG 2 1_555 ? ? ? ? ? ? ? 1.442 ? covale9 covale ? ? K NAG . O4 ? ? ? 1_555 L BMA . C1 ? ? C NAG 2 C BMA 3 1_555 ? ? ? ? ? ? ? 1.445 ? covale10 covale ? ? L BMA . O3 ? ? ? 1_555 N MAN . C1 ? ? C BMA 3 C MAN 5 1_555 ? ? ? ? ? ? ? 1.443 ? covale11 covale ? ? L BMA . O6 ? ? ? 1_555 M MAN . C1 ? ? C BMA 3 C MAN 4 1_555 ? ? ? ? ? ? ? 1.436 ? covale12 covale ? ? P NAG . O4 ? ? ? 1_555 Q NAG . C1 ? ? D NAG 1 D NAG 2 1_555 ? ? ? ? ? ? ? 1.442 ? covale13 covale ? ? Q NAG . O4 ? ? ? 1_555 R BMA . C1 ? ? D NAG 2 D BMA 3 1_555 ? ? ? ? ? ? ? 1.444 ? covale14 covale ? ? R BMA . O3 ? ? ? 1_555 T MAN . C1 ? ? D BMA 3 D MAN 5 1_555 ? ? ? ? ? ? ? 1.445 ? covale15 covale ? ? R BMA . O6 ? ? ? 1_555 S MAN . C1 ? ? D BMA 3 D MAN 4 1_555 ? ? ? ? ? ? ? 1.447 ? # loop_ _struct_conn_type.id _struct_conn_type.criteria _struct_conn_type.reference disulf ? ? covale ? ? # loop_ _struct_mon_prot_cis.pdbx_id _struct_mon_prot_cis.label_comp_id _struct_mon_prot_cis.label_seq_id _struct_mon_prot_cis.label_asym_id _struct_mon_prot_cis.label_alt_id _struct_mon_prot_cis.pdbx_PDB_ins_code _struct_mon_prot_cis.auth_comp_id _struct_mon_prot_cis.auth_seq_id _struct_mon_prot_cis.auth_asym_id _struct_mon_prot_cis.pdbx_label_comp_id_2 _struct_mon_prot_cis.pdbx_label_seq_id_2 _struct_mon_prot_cis.pdbx_label_asym_id_2 _struct_mon_prot_cis.pdbx_PDB_ins_code_2 _struct_mon_prot_cis.pdbx_auth_comp_id_2 _struct_mon_prot_cis.pdbx_auth_seq_id_2 _struct_mon_prot_cis.pdbx_auth_asym_id_2 _struct_mon_prot_cis.pdbx_PDB_model_num _struct_mon_prot_cis.pdbx_omega_angle 1 MET 146 A . ? MET 470 A PRO 147 A ? PRO 471 A 1 -5.58 2 SER 208 A . ? SER 532 A PRO 209 A ? PRO 533 A 1 6.13 3 MET 146 B . ? MET 470 B PRO 147 B ? PRO 471 B 1 -1.45 4 SER 208 B . ? SER 532 B PRO 209 B ? PRO 533 B 1 -11.34 5 MET 146 C . ? MET 470 C PRO 147 C ? PRO 471 C 1 -0.63 6 SER 208 C . ? SER 532 C PRO 209 C ? PRO 533 C 1 0.73 7 MET 146 D . ? MET 470 D PRO 147 D ? PRO 471 D 1 -2.50 8 SER 208 D . ? SER 532 D PRO 209 D ? PRO 533 D 1 -6.64 # loop_ _struct_sheet.id _struct_sheet.type _struct_sheet.number_strands _struct_sheet.details A ? 8 ? B ? 3 ? C ? 4 ? D ? 4 ? E ? 4 ? F ? 4 ? G ? 3 ? H ? 4 ? I ? 4 ? J ? 4 ? K ? 4 ? L ? 3 ? M ? 4 ? N ? 4 ? O ? 4 ? P ? 3 ? Q ? 4 ? R ? 4 ? S ? 4 ? # loop_ _struct_sheet_order.sheet_id _struct_sheet_order.range_id_1 _struct_sheet_order.range_id_2 _struct_sheet_order.offset _struct_sheet_order.sense A 1 2 ? anti-parallel A 2 3 ? anti-parallel A 3 4 ? anti-parallel A 4 5 ? anti-parallel A 5 6 ? anti-parallel A 6 7 ? anti-parallel A 7 8 ? anti-parallel B 1 2 ? anti-parallel B 2 3 ? anti-parallel C 1 2 ? anti-parallel C 2 3 ? anti-parallel C 3 4 ? anti-parallel D 1 2 ? anti-parallel D 2 3 ? anti-parallel D 3 4 ? anti-parallel E 1 2 ? anti-parallel E 2 3 ? anti-parallel E 3 4 ? anti-parallel F 1 2 ? anti-parallel F 2 3 ? anti-parallel F 3 4 ? anti-parallel G 1 2 ? anti-parallel G 2 3 ? anti-parallel H 1 2 ? anti-parallel H 2 3 ? anti-parallel H 3 4 ? anti-parallel I 1 2 ? anti-parallel I 2 3 ? anti-parallel I 3 4 ? anti-parallel J 1 2 ? anti-parallel J 2 3 ? anti-parallel J 3 4 ? anti-parallel K 1 2 ? anti-parallel K 2 3 ? anti-parallel K 3 4 ? anti-parallel L 1 2 ? anti-parallel L 2 3 ? anti-parallel M 1 2 ? anti-parallel M 2 3 ? anti-parallel M 3 4 ? anti-parallel N 1 2 ? anti-parallel N 2 3 ? anti-parallel N 3 4 ? anti-parallel O 1 2 ? anti-parallel O 2 3 ? anti-parallel O 3 4 ? anti-parallel P 1 2 ? anti-parallel P 2 3 ? anti-parallel Q 1 2 ? anti-parallel Q 2 3 ? anti-parallel Q 3 4 ? anti-parallel R 1 2 ? anti-parallel R 2 3 ? anti-parallel R 3 4 ? anti-parallel S 1 2 ? anti-parallel S 2 3 ? anti-parallel S 3 4 ? anti-parallel # loop_ _struct_sheet_range.sheet_id _struct_sheet_range.id _struct_sheet_range.beg_label_comp_id _struct_sheet_range.beg_label_asym_id _struct_sheet_range.beg_label_seq_id _struct_sheet_range.pdbx_beg_PDB_ins_code _struct_sheet_range.end_label_comp_id _struct_sheet_range.end_label_asym_id _struct_sheet_range.end_label_seq_id _struct_sheet_range.pdbx_end_PDB_ins_code _struct_sheet_range.beg_auth_comp_id _struct_sheet_range.beg_auth_asym_id _struct_sheet_range.beg_auth_seq_id _struct_sheet_range.end_auth_comp_id _struct_sheet_range.end_auth_asym_id _struct_sheet_range.end_auth_seq_id A 1 SER A 13 ? SER A 17 ? SER A 337 SER A 341 A 2 THR A 31 ? ASP A 38 ? THR A 355 ASP A 362 A 3 LEU A 73 ? PRO A 80 ? LEU A 397 PRO A 404 A 4 THR A 62 ? LYS A 67 ? THR A 386 LYS A 391 A 5 THR D 62 ? LYS D 67 ? THR D 386 LYS D 391 A 6 LEU D 73 ? PRO D 80 ? LEU D 397 PRO D 404 A 7 THR D 31 ? ASP D 38 ? THR D 355 ASP D 362 A 8 SER D 13 ? SER D 17 ? SER D 337 SER D 341 B 1 GLN A 47 ? ARG A 52 ? GLN A 371 ARG A 376 B 2 TYR A 92 ? THR A 97 ? TYR A 416 THR A 421 B 3 LEU A 105 ? THR A 109 ? LEU A 429 THR A 433 C 1 GLU A 120 ? ALA A 125 ? GLU A 444 ALA A 449 C 2 LYS A 135 ? PHE A 145 ? LYS A 459 PHE A 469 C 3 PHE A 179 ? THR A 188 ? PHE A 503 THR A 512 C 4 HIS A 166 ? THR A 168 ? HIS A 490 THR A 492 D 1 GLU A 120 ? ALA A 125 ? GLU A 444 ALA A 449 D 2 LYS A 135 ? PHE A 145 ? LYS A 459 PHE A 469 D 3 PHE A 179 ? THR A 188 ? PHE A 503 THR A 512 D 4 ARG A 172 ? LYS A 173 ? ARG A 496 LYS A 497 E 1 VAL A 159 ? GLN A 160 ? VAL A 483 GLN A 484 E 2 SER A 151 ? HIS A 156 ? SER A 475 HIS A 480 E 3 PHE A 198 ? VAL A 203 ? PHE A 522 VAL A 527 E 4 THR A 212 ? VAL A 217 ? THR A 536 VAL A 541 F 1 SER B 13 ? LEU B 16 ? SER B 337 LEU B 340 F 2 THR B 31 ? VAL B 37 ? THR B 355 VAL B 361 F 3 LEU B 73 ? PRO B 80 ? LEU B 397 PRO B 404 F 4 THR B 62 ? LYS B 67 ? THR B 386 LYS B 391 G 1 GLN B 47 ? ARG B 52 ? GLN B 371 ARG B 376 G 2 TYR B 92 ? THR B 97 ? TYR B 416 THR B 421 G 3 LEU B 105 ? THR B 109 ? LEU B 429 THR B 433 H 1 GLU B 120 ? ALA B 125 ? GLU B 444 ALA B 449 H 2 LYS B 135 ? PHE B 145 ? LYS B 459 PHE B 469 H 3 PHE B 179 ? THR B 188 ? PHE B 503 THR B 512 H 4 HIS B 166 ? THR B 168 ? HIS B 490 THR B 492 I 1 GLU B 120 ? ALA B 125 ? GLU B 444 ALA B 449 I 2 LYS B 135 ? PHE B 145 ? LYS B 459 PHE B 469 I 3 PHE B 179 ? THR B 188 ? PHE B 503 THR B 512 I 4 ARG B 172 ? LYS B 173 ? ARG B 496 LYS B 497 J 1 VAL B 159 ? GLN B 160 ? VAL B 483 GLN B 484 J 2 SER B 151 ? HIS B 156 ? SER B 475 HIS B 480 J 3 PHE B 198 ? VAL B 203 ? PHE B 522 VAL B 527 J 4 THR B 212 ? VAL B 217 ? THR B 536 VAL B 541 K 1 SER C 13 ? LEU C 16 ? SER C 337 LEU C 340 K 2 THR C 31 ? ASP C 38 ? THR C 355 ASP C 362 K 3 LEU C 73 ? PRO C 80 ? LEU C 397 PRO C 404 K 4 THR C 62 ? LYS C 67 ? THR C 386 LYS C 391 L 1 GLN C 47 ? ARG C 52 ? GLN C 371 ARG C 376 L 2 THR C 91 ? THR C 97 ? THR C 415 THR C 421 L 3 LEU C 105 ? THR C 110 ? LEU C 429 THR C 434 M 1 GLU C 120 ? ALA C 125 ? GLU C 444 ALA C 449 M 2 LYS C 135 ? PHE C 145 ? LYS C 459 PHE C 469 M 3 PHE C 179 ? THR C 188 ? PHE C 503 THR C 512 M 4 HIS C 166 ? THR C 168 ? HIS C 490 THR C 492 N 1 GLU C 120 ? ALA C 125 ? GLU C 444 ALA C 449 N 2 LYS C 135 ? PHE C 145 ? LYS C 459 PHE C 469 N 3 PHE C 179 ? THR C 188 ? PHE C 503 THR C 512 N 4 ARG C 172 ? LYS C 173 ? ARG C 496 LYS C 497 O 1 VAL C 159 ? GLN C 160 ? VAL C 483 GLN C 484 O 2 SER C 151 ? HIS C 156 ? SER C 475 HIS C 480 O 3 PHE C 198 ? VAL C 203 ? PHE C 522 VAL C 527 O 4 THR C 212 ? VAL C 217 ? THR C 536 VAL C 541 P 1 GLN D 47 ? ARG D 52 ? GLN D 371 ARG D 376 P 2 TYR D 92 ? THR D 97 ? TYR D 416 THR D 421 P 3 LEU D 105 ? THR D 109 ? LEU D 429 THR D 433 Q 1 GLU D 120 ? ALA D 125 ? GLU D 444 ALA D 449 Q 2 LYS D 135 ? PHE D 145 ? LYS D 459 PHE D 469 Q 3 PHE D 179 ? THR D 188 ? PHE D 503 THR D 512 Q 4 HIS D 166 ? THR D 168 ? HIS D 490 THR D 492 R 1 GLU D 120 ? ALA D 125 ? GLU D 444 ALA D 449 R 2 LYS D 135 ? PHE D 145 ? LYS D 459 PHE D 469 R 3 PHE D 179 ? THR D 188 ? PHE D 503 THR D 512 R 4 ARG D 172 ? LYS D 173 ? ARG D 496 LYS D 497 S 1 VAL D 159 ? GLN D 160 ? VAL D 483 GLN D 484 S 2 SER D 151 ? HIS D 156 ? SER D 475 HIS D 480 S 3 PHE D 198 ? VAL D 203 ? PHE D 522 VAL D 527 S 4 THR D 212 ? VAL D 217 ? THR D 536 VAL D 541 # loop_ _pdbx_struct_sheet_hbond.sheet_id _pdbx_struct_sheet_hbond.range_id_1 _pdbx_struct_sheet_hbond.range_id_2 _pdbx_struct_sheet_hbond.range_1_label_atom_id _pdbx_struct_sheet_hbond.range_1_label_comp_id _pdbx_struct_sheet_hbond.range_1_label_asym_id _pdbx_struct_sheet_hbond.range_1_label_seq_id _pdbx_struct_sheet_hbond.range_1_PDB_ins_code _pdbx_struct_sheet_hbond.range_1_auth_atom_id _pdbx_struct_sheet_hbond.range_1_auth_comp_id _pdbx_struct_sheet_hbond.range_1_auth_asym_id _pdbx_struct_sheet_hbond.range_1_auth_seq_id _pdbx_struct_sheet_hbond.range_2_label_atom_id _pdbx_struct_sheet_hbond.range_2_label_comp_id _pdbx_struct_sheet_hbond.range_2_label_asym_id _pdbx_struct_sheet_hbond.range_2_label_seq_id _pdbx_struct_sheet_hbond.range_2_PDB_ins_code _pdbx_struct_sheet_hbond.range_2_auth_atom_id _pdbx_struct_sheet_hbond.range_2_auth_comp_id _pdbx_struct_sheet_hbond.range_2_auth_asym_id _pdbx_struct_sheet_hbond.range_2_auth_seq_id A 1 2 N TYR A 15 ? N TYR A 339 O LEU A 35 ? O LEU A 359 A 2 3 N CYS A 34 ? N CYS A 358 O SER A 77 ? O SER A 401 A 3 4 O THR A 78 ? O THR A 402 N THR A 62 ? N THR A 386 A 4 5 N ARG A 63 ? N ARG A 387 O GLU D 65 ? O GLU D 389 A 5 6 N THR D 62 ? N THR D 386 O THR D 78 ? O THR D 402 A 6 7 O VAL D 75 ? O VAL D 399 N VAL D 36 ? N VAL D 360 A 7 8 O LEU D 35 ? O LEU D 359 N TYR D 15 ? N TYR D 339 B 1 2 N THR A 49 ? N THR A 373 O ARG A 95 ? O ARG A 419 B 2 3 N CYS A 94 ? N CYS A 418 O ARG A 107 ? O ARG A 431 C 1 2 N TYR A 122 ? N TYR A 446 O LEU A 141 ? O LEU A 465 C 2 3 N LEU A 138 ? N LEU A 462 O LEU A 185 ? O LEU A 509 C 3 4 O ARG A 184 ? O ARG A 508 N SER A 167 ? N SER A 491 D 1 2 N TYR A 122 ? N TYR A 446 O LEU A 141 ? O LEU A 465 D 2 3 N LEU A 138 ? N LEU A 462 O LEU A 185 ? O LEU A 509 D 3 4 O PHE A 180 ? O PHE A 504 N ARG A 172 ? N ARG A 496 E 1 2 O VAL A 159 ? O VAL A 483 N HIS A 156 ? N HIS A 480 E 2 3 N SER A 151 ? N SER A 475 O VAL A 203 ? O VAL A 527 E 3 4 N ALA A 202 ? N ALA A 526 O VAL A 213 ? O VAL A 537 F 1 2 N TYR B 15 ? N TYR B 339 O LEU B 35 ? O LEU B 359 F 2 3 N ILE B 32 ? N ILE B 356 O LEU B 79 ? O LEU B 403 F 3 4 O THR B 76 ? O THR B 400 N LYS B 64 ? N LYS B 388 G 1 2 N THR B 49 ? N THR B 373 O ARG B 95 ? O ARG B 419 G 2 3 N VAL B 96 ? N VAL B 420 O LEU B 105 ? O LEU B 429 H 1 2 N PHE B 124 ? N PHE B 448 O ALA B 139 ? O ALA B 463 H 2 3 N LEU B 138 ? N LEU B 462 O LEU B 185 ? O LEU B 509 H 3 4 O ARG B 184 ? O ARG B 508 N SER B 167 ? N SER B 491 I 1 2 N PHE B 124 ? N PHE B 448 O ALA B 139 ? O ALA B 463 I 2 3 N LEU B 138 ? N LEU B 462 O LEU B 185 ? O LEU B 509 I 3 4 O PHE B 180 ? O PHE B 504 N ARG B 172 ? N ARG B 496 J 1 2 O VAL B 159 ? O VAL B 483 N HIS B 156 ? N HIS B 480 J 2 3 N GLN B 153 ? N GLN B 477 O ARG B 201 ? O ARG B 525 J 3 4 N PHE B 198 ? N PHE B 522 O VAL B 217 ? O VAL B 541 K 1 2 N TYR C 15 ? N TYR C 339 O LEU C 35 ? O LEU C 359 K 2 3 N VAL C 36 ? N VAL C 360 O VAL C 75 ? O VAL C 399 K 3 4 O THR C 76 ? O THR C 400 N LYS C 64 ? N LYS C 388 L 1 2 N GLN C 47 ? N GLN C 371 O THR C 97 ? O THR C 421 L 2 3 N VAL C 96 ? N VAL C 420 O LEU C 105 ? O LEU C 429 M 1 2 N PHE C 124 ? N PHE C 448 O ALA C 139 ? O ALA C 463 M 2 3 N ILE C 142 ? N ILE C 466 O VAL C 181 ? O VAL C 505 M 3 4 O ARG C 184 ? O ARG C 508 N SER C 167 ? N SER C 491 N 1 2 N PHE C 124 ? N PHE C 448 O ALA C 139 ? O ALA C 463 N 2 3 N ILE C 142 ? N ILE C 466 O VAL C 181 ? O VAL C 505 N 3 4 O PHE C 180 ? O PHE C 504 N ARG C 172 ? N ARG C 496 O 1 2 O VAL C 159 ? O VAL C 483 N HIS C 156 ? N HIS C 480 O 2 3 N GLN C 153 ? N GLN C 477 O ARG C 201 ? O ARG C 525 O 3 4 N ALA C 202 ? N ALA C 526 O VAL C 213 ? O VAL C 537 P 1 2 N THR D 49 ? N THR D 373 O ARG D 95 ? O ARG D 419 P 2 3 N VAL D 96 ? N VAL D 420 O LEU D 105 ? O LEU D 429 Q 1 2 N PHE D 124 ? N PHE D 448 O ALA D 139 ? O ALA D 463 Q 2 3 N LEU D 138 ? N LEU D 462 O LEU D 185 ? O LEU D 509 Q 3 4 O ARG D 184 ? O ARG D 508 N SER D 167 ? N SER D 491 R 1 2 N PHE D 124 ? N PHE D 448 O ALA D 139 ? O ALA D 463 R 2 3 N LEU D 138 ? N LEU D 462 O LEU D 185 ? O LEU D 509 R 3 4 O PHE D 180 ? O PHE D 504 N ARG D 172 ? N ARG D 496 S 1 2 O VAL D 159 ? O VAL D 483 N HIS D 156 ? N HIS D 480 S 2 3 N GLN D 153 ? N GLN D 477 O ARG D 201 ? O ARG D 525 S 3 4 N ALA D 202 ? N ALA D 526 O VAL D 213 ? O VAL D 537 # loop_ _struct_site.id _struct_site.pdbx_evidence_code _struct_site.pdbx_auth_asym_id _struct_site.pdbx_auth_comp_id _struct_site.pdbx_auth_seq_id _struct_site.pdbx_auth_ins_code _struct_site.pdbx_num_residues _struct_site.details AC1 Software ? ? ? ? 5 'BINDING SITE FOR RESIDUE NAG B 1' AC2 Software ? ? ? ? 5 'BINDING SITE FOR RESIDUE NAG B 2' AC3 Software ? ? ? ? 3 'BINDING SITE FOR RESIDUE BMA B 3' AC4 Software ? ? ? ? 1 'BINDING SITE FOR RESIDUE MAN B 4' AC5 Software ? ? ? ? 1 'BINDING SITE FOR RESIDUE MAN B 5' AC6 Software ? ? ? ? 4 'BINDING SITE FOR RESIDUE NAG C 1' AC7 Software ? ? ? ? 6 'BINDING SITE FOR RESIDUE NAG C 2' AC8 Software ? ? ? ? 3 'BINDING SITE FOR RESIDUE BMA C 3' AC9 Software ? ? ? ? 2 'BINDING SITE FOR RESIDUE MAN C 4' BC1 Software ? ? ? ? 1 'BINDING SITE FOR RESIDUE MAN C 5' BC2 Software ? ? ? ? 4 'BINDING SITE FOR RESIDUE NAG D 1' BC3 Software ? ? ? ? 5 'BINDING SITE FOR RESIDUE NAG D 2' BC4 Software ? ? ? ? 4 'BINDING SITE FOR RESIDUE BMA D 3' BC5 Software ? ? ? ? 3 'BINDING SITE FOR RESIDUE MAN D 4' BC6 Software ? ? ? ? 1 'BINDING SITE FOR RESIDUE MAN D 5' BC7 Software ? ? ? ? 3 'BINDING SITE FOR RESIDUE NH4 C 548' # loop_ _struct_site_gen.id _struct_site_gen.site_id _struct_site_gen.pdbx_num_res _struct_site_gen.label_comp_id _struct_site_gen.label_asym_id _struct_site_gen.label_seq_id _struct_site_gen.pdbx_auth_ins_code _struct_site_gen.auth_comp_id _struct_site_gen.auth_asym_id _struct_site_gen.auth_seq_id _struct_site_gen.label_atom_id _struct_site_gen.label_alt_id _struct_site_gen.symmetry _struct_site_gen.details 1 AC1 5 NAG F . ? NAG B 2 . ? 1_555 ? 2 AC1 5 VAL B 37 ? VAL B 361 . ? 1_555 ? 3 AC1 5 ASP B 38 ? ASP B 362 . ? 1_555 ? 4 AC1 5 GLN B 68 ? GLN B 392 . ? 1_555 ? 5 AC1 5 ASN B 70 ? ASN B 394 . ? 1_555 ? 6 AC2 5 NAG E . ? NAG B 1 . ? 1_555 ? 7 AC2 5 BMA G . ? BMA B 3 . ? 1_555 ? 8 AC2 5 TYR B 15 ? TYR B 339 . ? 1_555 ? 9 AC2 5 LEU B 35 ? LEU B 359 . ? 1_555 ? 10 AC2 5 GLN B 68 ? GLN B 392 . ? 1_555 ? 11 AC3 3 NAG F . ? NAG B 2 . ? 1_555 ? 12 AC3 3 MAN H . ? MAN B 4 . ? 1_555 ? 13 AC3 3 MAN I . ? MAN B 5 . ? 1_555 ? 14 AC4 1 BMA G . ? BMA B 3 . ? 1_555 ? 15 AC5 1 BMA G . ? BMA B 3 . ? 1_555 ? 16 AC6 4 NAG K . ? NAG C 2 . ? 1_555 ? 17 AC6 4 LEU C 39 ? LEU C 363 . ? 1_555 ? 18 AC6 4 ASN C 70 ? ASN C 394 . ? 1_555 ? 19 AC6 4 THR C 72 ? THR C 396 . ? 1_555 ? 20 AC7 6 NAG J . ? NAG C 1 . ? 1_555 ? 21 AC7 6 BMA L . ? BMA C 3 . ? 1_555 ? 22 AC7 6 MAN M . ? MAN C 4 . ? 1_555 ? 23 AC7 6 TYR C 15 ? TYR C 339 . ? 1_555 ? 24 AC7 6 LEU C 35 ? LEU C 359 . ? 1_555 ? 25 AC7 6 THR C 74 ? THR C 398 . ? 1_555 ? 26 AC8 3 NAG K . ? NAG C 2 . ? 1_555 ? 27 AC8 3 MAN M . ? MAN C 4 . ? 1_555 ? 28 AC8 3 MAN N . ? MAN C 5 . ? 1_555 ? 29 AC9 2 NAG K . ? NAG C 2 . ? 1_555 ? 30 AC9 2 BMA L . ? BMA C 3 . ? 1_555 ? 31 BC1 1 BMA L . ? BMA C 3 . ? 1_555 ? 32 BC2 4 NAG Q . ? NAG D 2 . ? 1_555 ? 33 BC2 4 VAL D 37 ? VAL D 361 . ? 1_555 ? 34 BC2 4 ASN D 70 ? ASN D 394 . ? 1_555 ? 35 BC2 4 THR D 72 ? THR D 396 . ? 1_555 ? 36 BC3 5 NAG P . ? NAG D 1 . ? 1_555 ? 37 BC3 5 BMA R . ? BMA D 3 . ? 1_555 ? 38 BC3 5 SER D 13 ? SER D 337 . ? 1_555 ? 39 BC3 5 TYR D 15 ? TYR D 339 . ? 1_555 ? 40 BC3 5 LEU D 35 ? LEU D 359 . ? 1_555 ? 41 BC4 4 NAG Q . ? NAG D 2 . ? 1_555 ? 42 BC4 4 MAN S . ? MAN D 4 . ? 1_555 ? 43 BC4 4 MAN T . ? MAN D 5 . ? 1_555 ? 44 BC4 4 TYR D 15 ? TYR D 339 . ? 1_555 ? 45 BC5 3 BMA R . ? BMA D 3 . ? 1_555 ? 46 BC5 3 HOH X . ? HOH D 133 . ? 1_555 ? 47 BC5 3 GLN D 170 ? GLN D 494 . ? 1_555 ? 48 BC6 1 BMA R . ? BMA D 3 . ? 1_555 ? 49 BC7 3 HOH W . ? HOH C 210 . ? 1_555 ? 50 BC7 3 SER C 17 ? SER C 341 . ? 1_555 ? 51 BC7 3 ARG C 18 ? ARG C 342 . ? 1_555 ? # _atom_sites.entry_id 3H9Z _atom_sites.fract_transf_matrix[1][1] 0.015230 _atom_sites.fract_transf_matrix[1][2] 0.000000 _atom_sites.fract_transf_matrix[1][3] 0.001978 _atom_sites.fract_transf_matrix[2][1] 0.000000 _atom_sites.fract_transf_matrix[2][2] 0.010065 _atom_sites.fract_transf_matrix[2][3] 0.000000 _atom_sites.fract_transf_matrix[3][1] 0.000000 _atom_sites.fract_transf_matrix[3][2] 0.000000 _atom_sites.fract_transf_matrix[3][3] 0.012988 _atom_sites.fract_transf_vector[1] 0.00000 _atom_sites.fract_transf_vector[2] 0.00000 _atom_sites.fract_transf_vector[3] 0.00000 # loop_ _atom_type.symbol C N O S # loop_ _atom_site.group_PDB _atom_site.id _atom_site.type_symbol _atom_site.label_atom_id _atom_site.label_alt_id _atom_site.label_comp_id _atom_site.label_asym_id _atom_site.label_entity_id _atom_site.label_seq_id _atom_site.pdbx_PDB_ins_code _atom_site.Cartn_x _atom_site.Cartn_y _atom_site.Cartn_z _atom_site.occupancy _atom_site.B_iso_or_equiv _atom_site.pdbx_formal_charge _atom_site.auth_seq_id _atom_site.auth_comp_id _atom_site.auth_asym_id _atom_site.auth_atom_id _atom_site.pdbx_PDB_model_num ATOM 1 N N . VAL A 1 12 ? 103.328 -39.371 45.610 1.00 43.35 ? 336 VAL A N 1 ATOM 2 C CA . VAL A 1 12 ? 102.499 -38.489 44.729 1.00 43.11 ? 336 VAL A CA 1 ATOM 3 C C . VAL A 1 12 ? 102.458 -37.042 45.222 1.00 42.43 ? 336 VAL A C 1 ATOM 4 O O . VAL A 1 12 ? 102.048 -36.784 46.346 1.00 43.86 ? 336 VAL A O 1 ATOM 5 C CB . VAL A 1 12 ? 101.056 -39.036 44.580 1.00 42.92 ? 336 VAL A CB 1 ATOM 6 C CG1 . VAL A 1 12 ? 100.210 -38.077 43.758 1.00 41.74 ? 336 VAL A CG1 1 ATOM 7 C CG2 . VAL A 1 12 ? 101.070 -40.429 43.927 1.00 42.59 ? 336 VAL A CG2 1 ATOM 8 N N . SER A 1 13 ? 102.878 -36.095 44.386 1.00 41.48 ? 337 SER A N 1 ATOM 9 C CA . SER A 1 13 ? 102.888 -34.689 44.784 1.00 41.42 ? 337 SER A CA 1 ATOM 10 C C . SER A 1 13 ? 102.250 -33.800 43.722 1.00 40.35 ? 337 SER A C 1 ATOM 11 O O . SER A 1 13 ? 102.335 -34.083 42.530 1.00 41.09 ? 337 SER A O 1 ATOM 12 C CB . SER A 1 13 ? 104.312 -34.216 45.100 1.00 42.15 ? 337 SER A CB 1 ATOM 13 O OG . SER A 1 13 ? 104.971 -33.732 43.939 1.00 43.15 ? 337 SER A OG 1 ATOM 14 N N . ALA A 1 14 ? 101.592 -32.731 44.154 1.00 38.82 ? 338 ALA A N 1 ATOM 15 C CA . ALA A 1 14 ? 100.803 -31.910 43.237 1.00 38.44 ? 338 ALA A CA 1 ATOM 16 C C . ALA A 1 14 ? 101.210 -30.440 43.308 1.00 38.43 ? 338 ALA A C 1 ATOM 17 O O . ALA A 1 14 ? 101.587 -29.931 44.359 1.00 40.23 ? 338 ALA A O 1 ATOM 18 C CB . ALA A 1 14 ? 99.324 -32.065 43.530 1.00 37.83 ? 338 ALA A CB 1 ATOM 19 N N . TYR A 1 15 ? 101.159 -29.756 42.176 1.00 38.56 ? 339 TYR A N 1 ATOM 20 C CA . TYR A 1 15 ? 101.550 -28.359 42.121 1.00 37.01 ? 339 TYR A CA 1 ATOM 21 C C . TYR A 1 15 ? 100.602 -27.587 41.216 1.00 36.70 ? 339 TYR A C 1 ATOM 22 O O . TYR A 1 15 ? 100.179 -28.066 40.155 1.00 38.31 ? 339 TYR A O 1 ATOM 23 C CB . TYR A 1 15 ? 102.952 -28.220 41.558 1.00 36.23 ? 339 TYR A CB 1 ATOM 24 C CG . TYR A 1 15 ? 104.013 -29.039 42.236 1.00 36.68 ? 339 TYR A CG 1 ATOM 25 C CD1 . TYR A 1 15 ? 104.452 -30.221 41.670 1.00 37.42 ? 339 TYR A CD1 1 ATOM 26 C CD2 . TYR A 1 15 ? 104.616 -28.614 43.420 1.00 37.39 ? 339 TYR A CD2 1 ATOM 27 C CE1 . TYR A 1 15 ? 105.449 -30.984 42.273 1.00 38.47 ? 339 TYR A CE1 1 ATOM 28 C CE2 . TYR A 1 15 ? 105.619 -29.372 44.037 1.00 37.75 ? 339 TYR A CE2 1 ATOM 29 C CZ . TYR A 1 15 ? 106.032 -30.559 43.454 1.00 37.87 ? 339 TYR A CZ 1 ATOM 30 O OH . TYR A 1 15 ? 107.020 -31.331 44.018 1.00 36.97 ? 339 TYR A OH 1 ATOM 31 N N . LEU A 1 16 ? 100.273 -26.380 41.645 1.00 34.88 ? 340 LEU A N 1 ATOM 32 C CA . LEU A 1 16 ? 99.383 -25.529 40.904 1.00 33.25 ? 340 LEU A CA 1 ATOM 33 C C . LEU A 1 16 ? 100.162 -24.255 40.715 1.00 31.62 ? 340 LEU A C 1 ATOM 34 O O . LEU A 1 16 ? 100.527 -23.614 41.680 1.00 30.43 ? 340 LEU A O 1 ATOM 35 C CB . LEU A 1 16 ? 98.077 -25.284 41.679 1.00 33.02 ? 340 LEU A CB 1 ATOM 36 C CG . LEU A 1 16 ? 97.033 -24.431 40.935 1.00 32.91 ? 340 LEU A CG 1 ATOM 37 C CD1 . LEU A 1 16 ? 96.862 -24.896 39.508 1.00 30.01 ? 340 LEU A CD1 1 ATOM 38 C CD2 . LEU A 1 16 ? 95.675 -24.352 41.653 1.00 32.69 ? 340 LEU A CD2 1 ATOM 39 N N . SER A 1 17 ? 100.420 -23.898 39.465 1.00 34.58 ? 341 SER A N 1 ATOM 40 C CA . SER A 1 17 ? 101.204 -22.700 39.133 1.00 36.00 ? 341 SER A CA 1 ATOM 41 C C . SER A 1 17 ? 100.321 -21.534 38.750 1.00 37.13 ? 341 SER A C 1 ATOM 42 O O . SER A 1 17 ? 99.224 -21.698 38.220 1.00 40.70 ? 341 SER A O 1 ATOM 43 C CB . SER A 1 17 ? 102.063 -22.966 37.911 1.00 36.61 ? 341 SER A CB 1 ATOM 44 O OG . SER A 1 17 ? 101.188 -23.209 36.832 1.00 37.59 ? 341 SER A OG 1 ATOM 45 N N . ARG A 1 18 ? 100.836 -20.340 38.983 1.00 37.33 ? 342 ARG A N 1 ATOM 46 C CA . ARG A 1 18 ? 100.193 -19.126 38.530 1.00 35.10 ? 342 ARG A CA 1 ATOM 47 C C . ARG A 1 18 ? 100.522 -18.841 37.076 1.00 32.92 ? 342 ARG A C 1 ATOM 48 O O . ARG A 1 18 ? 101.532 -19.294 36.575 1.00 31.94 ? 342 ARG A O 1 ATOM 49 C CB . ARG A 1 18 ? 100.705 -17.975 39.387 1.00 36.50 ? 342 ARG A CB 1 ATOM 50 C CG . ARG A 1 18 ? 100.224 -17.994 40.818 1.00 37.30 ? 342 ARG A CG 1 ATOM 51 C CD . ARG A 1 18 ? 100.806 -16.815 41.587 1.00 39.46 ? 342 ARG A CD 1 ATOM 52 N NE . ARG A 1 18 ? 102.244 -16.994 41.775 1.00 40.96 ? 342 ARG A NE 1 ATOM 53 C CZ . ARG A 1 18 ? 102.788 -17.522 42.862 1.00 42.46 ? 342 ARG A CZ 1 ATOM 54 N NH1 . ARG A 1 18 ? 102.024 -17.910 43.879 1.00 43.04 ? 342 ARG A NH1 1 ATOM 55 N NH2 . ARG A 1 18 ? 104.101 -17.651 42.931 1.00 43.47 ? 342 ARG A NH2 1 ATOM 56 N N . PRO A 1 19 ? 99.690 -18.040 36.396 1.00 32.53 ? 343 PRO A N 1 ATOM 57 C CA . PRO A 1 19 ? 99.927 -17.688 34.998 1.00 31.54 ? 343 PRO A CA 1 ATOM 58 C C . PRO A 1 19 ? 101.234 -16.956 34.812 1.00 32.57 ? 343 PRO A C 1 ATOM 59 O O . PRO A 1 19 ? 101.649 -16.206 35.707 1.00 34.82 ? 343 PRO A O 1 ATOM 60 C CB . PRO A 1 19 ? 98.802 -16.718 34.672 1.00 31.58 ? 343 PRO A CB 1 ATOM 61 C CG . PRO A 1 19 ? 97.805 -16.885 35.780 1.00 31.81 ? 343 PRO A CG 1 ATOM 62 C CD . PRO A 1 19 ? 98.596 -17.253 36.981 1.00 31.47 ? 343 PRO A CD 1 ATOM 63 N N . SER A 1 20 ? 101.871 -17.149 33.660 1.00 31.07 ? 344 SER A N 1 ATOM 64 C CA . SER A 1 20 ? 103.076 -16.397 33.360 1.00 30.84 ? 344 SER A CA 1 ATOM 65 C C . SER A 1 20 ? 102.709 -14.946 33.059 1.00 30.21 ? 344 SER A C 1 ATOM 66 O O . SER A 1 20 ? 101.726 -14.677 32.374 1.00 30.87 ? 344 SER A O 1 ATOM 67 C CB . SER A 1 20 ? 103.817 -17.025 32.185 1.00 30.44 ? 344 SER A CB 1 ATOM 68 O OG . SER A 1 20 ? 103.205 -16.649 30.968 1.00 30.46 ? 344 SER A OG 1 ATOM 69 N N . PRO A 1 21 ? 103.491 -13.996 33.577 1.00 29.42 ? 345 PRO A N 1 ATOM 70 C CA . PRO A 1 21 ? 103.248 -12.591 33.242 1.00 29.77 ? 345 PRO A CA 1 ATOM 71 C C . PRO A 1 21 ? 103.147 -12.353 31.729 1.00 30.42 ? 345 PRO A C 1 ATOM 72 O O . PRO A 1 21 ? 102.254 -11.644 31.268 1.00 30.87 ? 345 PRO A O 1 ATOM 73 C CB . PRO A 1 21 ? 104.468 -11.881 33.819 1.00 29.40 ? 345 PRO A CB 1 ATOM 74 C CG . PRO A 1 21 ? 104.891 -12.733 34.934 1.00 29.56 ? 345 PRO A CG 1 ATOM 75 C CD . PRO A 1 21 ? 104.605 -14.152 34.520 1.00 29.10 ? 345 PRO A CD 1 ATOM 76 N N . PHE A 1 22 ? 104.044 -12.948 30.950 1.00 31.09 ? 346 PHE A N 1 ATOM 77 C CA . PHE A 1 22 ? 103.953 -12.827 29.507 1.00 30.38 ? 346 PHE A CA 1 ATOM 78 C C . PHE A 1 22 ? 102.526 -13.132 29.030 1.00 30.24 ? 346 PHE A C 1 ATOM 79 O O . PHE A 1 22 ? 101.867 -12.314 28.395 1.00 28.40 ? 346 PHE A O 1 ATOM 80 C CB . PHE A 1 22 ? 104.922 -13.804 28.843 1.00 29.80 ? 346 PHE A CB 1 ATOM 81 C CG . PHE A 1 22 ? 104.836 -13.808 27.340 1.00 28.54 ? 346 PHE A CG 1 ATOM 82 C CD1 . PHE A 1 22 ? 104.926 -12.623 26.622 1.00 28.07 ? 346 PHE A CD1 1 ATOM 83 C CD2 . PHE A 1 22 ? 104.665 -14.988 26.656 1.00 27.73 ? 346 PHE A CD2 1 ATOM 84 C CE1 . PHE A 1 22 ? 104.854 -12.618 25.239 1.00 29.34 ? 346 PHE A CE1 1 ATOM 85 C CE2 . PHE A 1 22 ? 104.591 -14.997 25.260 1.00 28.54 ? 346 PHE A CE2 1 ATOM 86 C CZ . PHE A 1 22 ? 104.683 -13.813 24.549 1.00 28.83 ? 346 PHE A CZ 1 ATOM 87 N N . ASP A 1 23 ? 102.065 -14.332 29.341 1.00 31.69 ? 347 ASP A N 1 ATOM 88 C CA . ASP A 1 23 ? 100.761 -14.777 28.894 1.00 33.26 ? 347 ASP A CA 1 ATOM 89 C C . ASP A 1 23 ? 99.684 -13.838 29.435 1.00 33.31 ? 347 ASP A C 1 ATOM 90 O O . ASP A 1 23 ? 98.761 -13.491 28.689 1.00 35.00 ? 347 ASP A O 1 ATOM 91 C CB . ASP A 1 23 ? 100.496 -16.223 29.339 1.00 33.65 ? 347 ASP A CB 1 ATOM 92 C CG . ASP A 1 23 ? 101.257 -17.247 28.499 1.00 34.21 ? 347 ASP A CG 1 ATOM 93 O OD1 . ASP A 1 23 ? 101.280 -18.441 28.890 1.00 34.81 ? 347 ASP A OD1 1 ATOM 94 O OD2 . ASP A 1 23 ? 101.837 -16.863 27.455 1.00 33.60 ? 347 ASP A OD2 1 ATOM 95 N N . LEU A 1 24 ? 99.819 -13.417 30.695 1.00 31.15 ? 348 LEU A N 1 ATOM 96 C CA . LEU A 1 24 ? 98.840 -12.537 31.365 1.00 30.43 ? 348 LEU A CA 1 ATOM 97 C C . LEU A 1 24 ? 98.800 -11.113 30.801 1.00 30.74 ? 348 LEU A C 1 ATOM 98 O O . LEU A 1 24 ? 97.735 -10.609 30.430 1.00 31.61 ? 348 LEU A O 1 ATOM 99 C CB . LEU A 1 24 ? 99.090 -12.494 32.884 1.00 29.36 ? 348 LEU A CB 1 ATOM 100 C CG . LEU A 1 24 ? 98.101 -11.729 33.773 1.00 28.28 ? 348 LEU A CG 1 ATOM 101 C CD1 . LEU A 1 24 ? 96.705 -12.277 33.637 1.00 27.70 ? 348 LEU A CD1 1 ATOM 102 C CD2 . LEU A 1 24 ? 98.510 -11.712 35.256 1.00 26.69 ? 348 LEU A CD2 1 ATOM 103 N N . PHE A 1 25 ? 99.946 -10.454 30.689 1.00 30.45 ? 349 PHE A N 1 ATOM 104 C CA . PHE A 1 25 ? 99.930 -9.029 30.337 1.00 29.82 ? 349 PHE A CA 1 ATOM 105 C C . PHE A 1 25 ? 100.162 -8.734 28.866 1.00 30.85 ? 349 PHE A C 1 ATOM 106 O O . PHE A 1 25 ? 99.632 -7.760 28.351 1.00 32.87 ? 349 PHE A O 1 ATOM 107 C CB . PHE A 1 25 ? 100.973 -8.263 31.144 1.00 29.79 ? 349 PHE A CB 1 ATOM 108 C CG . PHE A 1 25 ? 100.775 -8.350 32.622 1.00 28.15 ? 349 PHE A CG 1 ATOM 109 C CD1 . PHE A 1 25 ? 101.713 -8.981 33.420 1.00 27.97 ? 349 PHE A CD1 1 ATOM 110 C CD2 . PHE A 1 25 ? 99.651 -7.806 33.213 1.00 28.10 ? 349 PHE A CD2 1 ATOM 111 C CE1 . PHE A 1 25 ? 101.523 -9.080 34.795 1.00 28.11 ? 349 PHE A CE1 1 ATOM 112 C CE2 . PHE A 1 25 ? 99.461 -7.887 34.600 1.00 27.97 ? 349 PHE A CE2 1 ATOM 113 C CZ . PHE A 1 25 ? 100.391 -8.523 35.388 1.00 27.54 ? 349 PHE A CZ 1 ATOM 114 N N . ILE A 1 26 ? 100.958 -9.539 28.173 1.00 32.01 ? 350 ILE A N 1 ATOM 115 C CA . ILE A 1 26 ? 101.186 -9.276 26.761 1.00 32.04 ? 350 ILE A CA 1 ATOM 116 C C . ILE A 1 26 ? 100.193 -10.003 25.861 1.00 33.84 ? 350 ILE A C 1 ATOM 117 O O . ILE A 1 26 ? 99.477 -9.355 25.106 1.00 35.06 ? 350 ILE A O 1 ATOM 118 C CB . ILE A 1 26 ? 102.627 -9.599 26.331 1.00 30.86 ? 350 ILE A CB 1 ATOM 119 C CG1 . ILE A 1 26 ? 103.615 -8.934 27.285 1.00 30.01 ? 350 ILE A CG1 1 ATOM 120 C CG2 . ILE A 1 26 ? 102.866 -9.137 24.885 1.00 28.78 ? 350 ILE A CG2 1 ATOM 121 C CD1 . ILE A 1 26 ? 103.272 -7.492 27.583 1.00 28.95 ? 350 ILE A CD1 1 ATOM 122 N N . ARG A 1 27 ? 100.160 -11.332 25.921 1.00 35.45 ? 351 ARG A N 1 ATOM 123 C CA . ARG A 1 27 ? 99.262 -12.119 25.069 1.00 38.06 ? 351 ARG A CA 1 ATOM 124 C C . ARG A 1 27 ? 97.820 -12.060 25.569 1.00 39.05 ? 351 ARG A C 1 ATOM 125 O O . ARG A 1 27 ? 96.871 -12.361 24.841 1.00 38.12 ? 351 ARG A O 1 ATOM 126 C CB . ARG A 1 27 ? 99.692 -13.584 25.027 1.00 38.58 ? 351 ARG A CB 1 ATOM 127 C CG . ARG A 1 27 ? 101.064 -13.794 24.417 1.00 40.30 ? 351 ARG A CG 1 ATOM 128 C CD . ARG A 1 27 ? 101.365 -15.282 24.201 1.00 40.84 ? 351 ARG A CD 1 ATOM 129 N NE . ARG A 1 27 ? 100.316 -15.887 23.401 1.00 41.17 ? 351 ARG A NE 1 ATOM 130 C CZ . ARG A 1 27 ? 99.375 -16.682 23.878 1.00 41.11 ? 351 ARG A CZ 1 ATOM 131 N NH1 . ARG A 1 27 ? 99.367 -16.994 25.163 1.00 42.34 ? 351 ARG A NH1 1 ATOM 132 N NH2 . ARG A 1 27 ? 98.450 -17.165 23.061 1.00 41.11 ? 351 ARG A NH2 1 ATOM 133 N N . LYS A 1 28 ? 97.664 -11.686 26.828 1.00 40.10 ? 352 LYS A N 1 ATOM 134 C CA . LYS A 1 28 ? 96.349 -11.570 27.418 1.00 41.53 ? 352 LYS A CA 1 ATOM 135 C C . LYS A 1 28 ? 95.555 -12.858 27.256 1.00 39.96 ? 352 LYS A C 1 ATOM 136 O O . LYS A 1 28 ? 94.347 -12.824 27.038 1.00 39.71 ? 352 LYS A O 1 ATOM 137 C CB . LYS A 1 28 ? 95.608 -10.384 26.805 1.00 44.07 ? 352 LYS A CB 1 ATOM 138 C CG . LYS A 1 28 ? 96.084 -9.052 27.370 1.00 46.27 ? 352 LYS A CG 1 ATOM 139 C CD . LYS A 1 28 ? 95.296 -7.891 26.808 1.00 47.91 ? 352 LYS A CD 1 ATOM 140 C CE . LYS A 1 28 ? 95.742 -6.593 27.456 1.00 49.30 ? 352 LYS A CE 1 ATOM 141 N NZ . LYS A 1 28 ? 97.203 -6.407 27.210 1.00 51.16 ? 352 LYS A NZ 1 ATOM 142 N N . SER A 1 29 ? 96.246 -13.987 27.365 1.00 38.29 ? 353 SER A N 1 ATOM 143 C CA . SER A 1 29 ? 95.585 -15.279 27.462 1.00 38.28 ? 353 SER A CA 1 ATOM 144 C C . SER A 1 29 ? 96.307 -16.146 28.500 1.00 36.48 ? 353 SER A C 1 ATOM 145 O O . SER A 1 29 ? 97.030 -17.081 28.171 1.00 37.36 ? 353 SER A O 1 ATOM 146 C CB . SER A 1 29 ? 95.508 -15.950 26.087 1.00 39.53 ? 353 SER A CB 1 ATOM 147 O OG . SER A 1 29 ? 96.794 -16.336 25.639 1.00 41.60 ? 353 SER A OG 1 ATOM 148 N N . PRO A 1 30 ? 96.105 -15.832 29.783 1.00 34.29 ? 354 PRO A N 1 ATOM 149 C CA . PRO A 1 30 ? 96.748 -16.555 30.852 1.00 33.42 ? 354 PRO A CA 1 ATOM 150 C C . PRO A 1 30 ? 96.171 -17.941 31.079 1.00 31.44 ? 354 PRO A C 1 ATOM 151 O O . PRO A 1 30 ? 94.998 -18.154 30.841 1.00 31.26 ? 354 PRO A O 1 ATOM 152 C CB . PRO A 1 30 ? 96.458 -15.675 32.065 1.00 34.50 ? 354 PRO A CB 1 ATOM 153 C CG . PRO A 1 30 ? 95.133 -15.077 31.757 1.00 34.58 ? 354 PRO A CG 1 ATOM 154 C CD . PRO A 1 30 ? 95.218 -14.777 30.303 1.00 35.29 ? 354 PRO A CD 1 ATOM 155 N N . THR A 1 31 ? 97.005 -18.858 31.548 1.00 30.02 ? 355 THR A N 1 ATOM 156 C CA . THR A 1 31 ? 96.591 -20.200 31.903 1.00 30.30 ? 355 THR A CA 1 ATOM 157 C C . THR A 1 31 ? 97.257 -20.611 33.230 1.00 31.29 ? 355 THR A C 1 ATOM 158 O O . THR A 1 31 ? 98.309 -20.068 33.633 1.00 32.42 ? 355 THR A O 1 ATOM 159 C CB . THR A 1 31 ? 96.979 -21.245 30.805 1.00 30.45 ? 355 THR A CB 1 ATOM 160 O OG1 . THR A 1 31 ? 98.406 -21.370 30.752 1.00 31.13 ? 355 THR A OG1 1 ATOM 161 C CG2 . THR A 1 31 ? 96.432 -20.882 29.407 1.00 27.18 ? 355 THR A CG2 1 ATOM 162 N N . ILE A 1 32 ? 96.648 -21.575 33.910 1.00 28.97 ? 356 ILE A N 1 ATOM 163 C CA . ILE A 1 32 ? 97.253 -22.136 35.100 1.00 28.68 ? 356 ILE A CA 1 ATOM 164 C C . ILE A 1 32 ? 97.387 -23.641 34.913 1.00 29.53 ? 356 ILE A C 1 ATOM 165 O O . ILE A 1 32 ? 96.597 -24.288 34.221 1.00 27.60 ? 356 ILE A O 1 ATOM 166 C CB . ILE A 1 32 ? 96.475 -21.794 36.409 1.00 28.10 ? 356 ILE A CB 1 ATOM 167 C CG1 . ILE A 1 32 ? 95.047 -22.310 36.356 1.00 27.70 ? 356 ILE A CG1 1 ATOM 168 C CG2 . ILE A 1 32 ? 96.443 -20.310 36.657 1.00 26.37 ? 356 ILE A CG2 1 ATOM 169 C CD1 . ILE A 1 32 ? 94.218 -21.839 37.495 1.00 29.04 ? 356 ILE A CD1 1 ATOM 170 N N . THR A 1 33 ? 98.405 -24.197 35.545 1.00 30.63 ? 357 THR A N 1 ATOM 171 C CA . THR A 1 33 ? 98.730 -25.575 35.307 1.00 32.57 ? 357 THR A CA 1 ATOM 172 C C . THR A 1 33 ? 98.758 -26.360 36.622 1.00 34.15 ? 357 THR A C 1 ATOM 173 O O . THR A 1 33 ? 99.422 -25.984 37.609 1.00 33.13 ? 357 THR A O 1 ATOM 174 C CB . THR A 1 33 ? 100.058 -25.664 34.532 1.00 34.15 ? 357 THR A CB 1 ATOM 175 O OG1 . THR A 1 33 ? 99.922 -25.015 33.238 1.00 33.69 ? 357 THR A OG1 1 ATOM 176 C CG2 . THR A 1 33 ? 100.438 -27.110 34.378 1.00 33.03 ? 357 THR A CG2 1 ATOM 177 N N . CYS A 1 34 ? 97.992 -27.446 36.624 1.00 34.69 ? 358 CYS A N 1 ATOM 178 C CA . CYS A 1 34 ? 97.993 -28.384 37.729 1.00 35.47 ? 358 CYS A CA 1 ATOM 179 C C . CYS A 1 34 ? 98.942 -29.520 37.344 1.00 35.29 ? 358 CYS A C 1 ATOM 180 O O . CYS A 1 34 ? 98.694 -30.264 36.391 1.00 34.12 ? 358 CYS A O 1 ATOM 181 C CB . CYS A 1 34 ? 96.572 -28.898 38.015 1.00 35.90 ? 358 CYS A CB 1 ATOM 182 S SG . CYS A 1 34 ? 96.363 -29.655 39.660 1.00 37.19 ? 358 CYS A SG 1 ATOM 183 N N . LEU A 1 35 ? 100.039 -29.618 38.087 1.00 36.07 ? 359 LEU A N 1 ATOM 184 C CA . LEU A 1 35 ? 101.057 -30.629 37.854 1.00 35.94 ? 359 LEU A CA 1 ATOM 185 C C . LEU A 1 35 ? 100.988 -31.671 38.955 1.00 37.97 ? 359 LEU A C 1 ATOM 186 O O . LEU A 1 35 ? 101.170 -31.376 40.148 1.00 38.30 ? 359 LEU A O 1 ATOM 187 C CB . LEU A 1 35 ? 102.455 -30.010 37.824 1.00 35.69 ? 359 LEU A CB 1 ATOM 188 C CG . LEU A 1 35 ? 103.628 -30.965 37.542 1.00 36.23 ? 359 LEU A CG 1 ATOM 189 C CD1 . LEU A 1 35 ? 103.498 -31.679 36.180 1.00 34.48 ? 359 LEU A CD1 1 ATOM 190 C CD2 . LEU A 1 35 ? 104.957 -30.223 37.618 1.00 35.17 ? 359 LEU A CD2 1 ATOM 191 N N . VAL A 1 36 ? 100.698 -32.894 38.533 1.00 38.52 ? 360 VAL A N 1 ATOM 192 C CA . VAL A 1 36 ? 100.690 -34.033 39.424 1.00 40.35 ? 360 VAL A CA 1 ATOM 193 C C . VAL A 1 36 ? 101.787 -35.003 39.003 1.00 42.75 ? 360 VAL A C 1 ATOM 194 O O . VAL A 1 36 ? 101.804 -35.477 37.860 1.00 43.01 ? 360 VAL A O 1 ATOM 195 C CB . VAL A 1 36 ? 99.336 -34.741 39.392 1.00 39.51 ? 360 VAL A CB 1 ATOM 196 C CG1 . VAL A 1 36 ? 99.310 -35.865 40.426 1.00 39.16 ? 360 VAL A CG1 1 ATOM 197 C CG2 . VAL A 1 36 ? 98.232 -33.725 39.648 1.00 38.23 ? 360 VAL A CG2 1 ATOM 198 N N . VAL A 1 37 ? 102.696 -35.276 39.937 1.00 44.86 ? 361 VAL A N 1 ATOM 199 C CA . VAL A 1 37 ? 103.775 -36.236 39.750 1.00 46.62 ? 361 VAL A CA 1 ATOM 200 C C . VAL A 1 37 ? 103.516 -37.494 40.588 1.00 49.51 ? 361 VAL A C 1 ATOM 201 O O . VAL A 1 37 ? 103.514 -37.426 41.814 1.00 49.33 ? 361 VAL A O 1 ATOM 202 C CB . VAL A 1 37 ? 105.111 -35.619 40.190 1.00 46.11 ? 361 VAL A CB 1 ATOM 203 C CG1 . VAL A 1 37 ? 106.163 -36.705 40.366 1.00 45.11 ? 361 VAL A CG1 1 ATOM 204 C CG2 . VAL A 1 37 ? 105.552 -34.553 39.195 1.00 45.52 ? 361 VAL A CG2 1 ATOM 205 N N . ASP A 1 38 ? 103.294 -38.634 39.929 1.00 52.99 ? 362 ASP A N 1 ATOM 206 C CA . ASP A 1 38 ? 103.019 -39.909 40.608 1.00 54.63 ? 362 ASP A CA 1 ATOM 207 C C . ASP A 1 38 ? 104.191 -40.881 40.485 1.00 55.44 ? 362 ASP A C 1 ATOM 208 O O . ASP A 1 38 ? 104.418 -41.465 39.425 1.00 55.59 ? 362 ASP A O 1 ATOM 209 C CB . ASP A 1 38 ? 101.747 -40.563 40.048 1.00 55.50 ? 362 ASP A CB 1 ATOM 210 C CG . ASP A 1 38 ? 101.390 -41.854 40.767 1.00 56.88 ? 362 ASP A CG 1 ATOM 211 O OD1 . ASP A 1 38 ? 102.011 -42.150 41.814 1.00 57.51 ? 362 ASP A OD1 1 ATOM 212 O OD2 . ASP A 1 38 ? 100.491 -42.579 40.286 1.00 57.85 ? 362 ASP A OD2 1 ATOM 213 N N . LEU A 1 39 ? 104.926 -41.068 41.578 1.00 56.92 ? 363 LEU A N 1 ATOM 214 C CA . LEU A 1 39 ? 106.183 -41.827 41.534 1.00 58.20 ? 363 LEU A CA 1 ATOM 215 C C . LEU A 1 39 ? 106.014 -43.364 41.499 1.00 58.84 ? 363 LEU A C 1 ATOM 216 O O . LEU A 1 39 ? 106.974 -44.098 41.236 1.00 57.46 ? 363 LEU A O 1 ATOM 217 C CB . LEU A 1 39 ? 107.097 -41.409 42.696 1.00 58.52 ? 363 LEU A CB 1 ATOM 218 C CG . LEU A 1 39 ? 107.517 -39.935 42.847 1.00 58.87 ? 363 LEU A CG 1 ATOM 219 C CD1 . LEU A 1 39 ? 108.438 -39.782 44.070 1.00 59.07 ? 363 LEU A CD1 1 ATOM 220 C CD2 . LEU A 1 39 ? 108.191 -39.359 41.602 1.00 57.95 ? 363 LEU A CD2 1 ATOM 221 N N . ALA A 1 40 ? 104.802 -43.849 41.762 1.00 59.97 ? 364 ALA A N 1 ATOM 222 C CA . ALA A 1 40 ? 104.476 -45.260 41.574 1.00 60.48 ? 364 ALA A CA 1 ATOM 223 C C . ALA A 1 40 ? 103.198 -45.367 40.744 1.00 61.56 ? 364 ALA A C 1 ATOM 224 O O . ALA A 1 40 ? 102.101 -45.435 41.304 1.00 61.52 ? 364 ALA A O 1 ATOM 225 C CB . ALA A 1 40 ? 104.311 -45.965 42.919 1.00 60.46 ? 364 ALA A CB 1 ATOM 226 N N . PRO A 1 41 ? 103.344 -45.364 39.404 1.00 62.95 ? 365 PRO A N 1 ATOM 227 C CA . PRO A 1 41 ? 102.277 -45.521 38.407 1.00 63.58 ? 365 PRO A CA 1 ATOM 228 C C . PRO A 1 41 ? 101.459 -46.805 38.570 1.00 64.21 ? 365 PRO A C 1 ATOM 229 O O . PRO A 1 41 ? 101.850 -47.865 38.070 1.00 62.97 ? 365 PRO A O 1 ATOM 230 C CB . PRO A 1 41 ? 103.036 -45.559 37.073 1.00 63.33 ? 365 PRO A CB 1 ATOM 231 C CG . PRO A 1 41 ? 104.305 -44.851 37.336 1.00 63.20 ? 365 PRO A CG 1 ATOM 232 C CD . PRO A 1 41 ? 104.655 -45.157 38.763 1.00 63.12 ? 365 PRO A CD 1 ATOM 233 N N . SER A 1 42 ? 100.330 -46.685 39.268 1.00 65.12 ? 366 SER A N 1 ATOM 234 C CA . SER A 1 42 ? 99.384 -47.783 39.430 1.00 65.25 ? 366 SER A CA 1 ATOM 235 C C . SER A 1 42 ? 98.467 -47.818 38.216 1.00 65.51 ? 366 SER A C 1 ATOM 236 O O . SER A 1 42 ? 98.413 -46.866 37.435 1.00 65.42 ? 366 SER A O 1 ATOM 237 C CB . SER A 1 42 ? 98.537 -47.584 40.689 1.00 64.79 ? 366 SER A CB 1 ATOM 238 O OG . SER A 1 42 ? 99.291 -46.981 41.726 1.00 64.43 ? 366 SER A OG 1 ATOM 239 N N . LYS A 1 43 ? 97.745 -48.919 38.062 1.00 65.53 ? 367 LYS A N 1 ATOM 240 C CA . LYS A 1 43 ? 96.673 -48.977 37.080 1.00 65.29 ? 367 LYS A CA 1 ATOM 241 C C . LYS A 1 43 ? 95.573 -47.982 37.515 1.00 64.42 ? 367 LYS A C 1 ATOM 242 O O . LYS A 1 43 ? 95.324 -47.798 38.717 1.00 64.43 ? 367 LYS A O 1 ATOM 243 C CB . LYS A 1 43 ? 96.177 -50.431 36.959 1.00 65.51 ? 367 LYS A CB 1 ATOM 244 C CG . LYS A 1 43 ? 95.376 -50.760 35.705 1.00 65.67 ? 367 LYS A CG 1 ATOM 245 C CD . LYS A 1 43 ? 96.126 -50.413 34.424 1.00 65.74 ? 367 LYS A CD 1 ATOM 246 C CE . LYS A 1 43 ? 95.244 -50.618 33.207 1.00 65.74 ? 367 LYS A CE 1 ATOM 247 N NZ . LYS A 1 43 ? 95.757 -49.842 32.046 1.00 65.96 ? 367 LYS A NZ 1 ATOM 248 N N . GLY A 1 44 ? 94.948 -47.310 36.544 1.00 62.75 ? 368 GLY A N 1 ATOM 249 C CA . GLY A 1 44 ? 93.763 -46.492 36.805 1.00 61.54 ? 368 GLY A CA 1 ATOM 250 C C . GLY A 1 44 ? 93.786 -45.164 36.067 1.00 60.95 ? 368 GLY A C 1 ATOM 251 O O . GLY A 1 44 ? 94.589 -44.970 35.159 1.00 61.13 ? 368 GLY A O 1 ATOM 252 N N . THR A 1 45 ? 92.912 -44.238 36.449 1.00 59.80 ? 369 THR A N 1 ATOM 253 C CA . THR A 1 45 ? 92.909 -42.908 35.835 1.00 59.23 ? 369 THR A CA 1 ATOM 254 C C . THR A 1 45 ? 92.939 -41.804 36.898 1.00 58.09 ? 369 THR A C 1 ATOM 255 O O . THR A 1 45 ? 91.985 -41.638 37.664 1.00 57.97 ? 369 THR A O 1 ATOM 256 C CB . THR A 1 45 ? 91.675 -42.677 34.908 1.00 59.37 ? 369 THR A CB 1 ATOM 257 O OG1 . THR A 1 45 ? 91.216 -43.915 34.342 1.00 59.80 ? 369 THR A OG1 1 ATOM 258 C CG2 . THR A 1 45 ? 92.024 -41.707 33.785 1.00 59.02 ? 369 THR A CG2 1 ATOM 259 N N . VAL A 1 46 ? 94.034 -41.049 36.943 1.00 56.62 ? 370 VAL A N 1 ATOM 260 C CA . VAL A 1 46 ? 94.107 -39.859 37.793 1.00 54.97 ? 370 VAL A CA 1 ATOM 261 C C . VAL A 1 46 ? 93.140 -38.815 37.259 1.00 53.63 ? 370 VAL A C 1 ATOM 262 O O . VAL A 1 46 ? 93.123 -38.559 36.051 1.00 54.21 ? 370 VAL A O 1 ATOM 263 C CB . VAL A 1 46 ? 95.518 -39.251 37.800 1.00 54.99 ? 370 VAL A CB 1 ATOM 264 C CG1 . VAL A 1 46 ? 95.657 -38.231 38.909 1.00 54.22 ? 370 VAL A CG1 1 ATOM 265 C CG2 . VAL A 1 46 ? 96.559 -40.352 37.951 1.00 55.56 ? 370 VAL A CG2 1 ATOM 266 N N . GLN A 1 47 ? 92.342 -38.229 38.153 1.00 51.82 ? 371 GLN A N 1 ATOM 267 C CA . GLN A 1 47 ? 91.366 -37.195 37.795 1.00 49.67 ? 371 GLN A CA 1 ATOM 268 C C . GLN A 1 47 ? 91.808 -35.828 38.294 1.00 46.02 ? 371 GLN A C 1 ATOM 269 O O . GLN A 1 47 ? 91.997 -35.651 39.496 1.00 44.36 ? 371 GLN A O 1 ATOM 270 C CB . GLN A 1 47 ? 90.018 -37.508 38.440 1.00 51.87 ? 371 GLN A CB 1 ATOM 271 C CG . GLN A 1 47 ? 89.291 -38.719 37.875 1.00 53.38 ? 371 GLN A CG 1 ATOM 272 C CD . GLN A 1 47 ? 88.395 -38.362 36.699 1.00 54.50 ? 371 GLN A CD 1 ATOM 273 O OE1 . GLN A 1 47 ? 87.247 -38.815 36.619 1.00 55.36 ? 371 GLN A OE1 1 ATOM 274 N NE2 . GLN A 1 47 ? 88.911 -37.542 35.784 1.00 54.96 ? 371 GLN A NE2 1 ATOM 275 N N . LEU A 1 48 ? 91.974 -34.874 37.376 1.00 42.66 ? 372 LEU A N 1 ATOM 276 C CA . LEU A 1 48 ? 92.140 -33.463 37.736 1.00 39.60 ? 372 LEU A CA 1 ATOM 277 C C . LEU A 1 48 ? 90.904 -32.688 37.327 1.00 37.55 ? 372 LEU A C 1 ATOM 278 O O . LEU A 1 48 ? 90.592 -32.615 36.133 1.00 35.97 ? 372 LEU A O 1 ATOM 279 C CB . LEU A 1 48 ? 93.328 -32.809 37.038 1.00 38.69 ? 372 LEU A CB 1 ATOM 280 C CG . LEU A 1 48 ? 94.703 -33.430 37.183 1.00 38.53 ? 372 LEU A CG 1 ATOM 281 C CD1 . LEU A 1 48 ? 95.734 -32.365 36.913 1.00 38.53 ? 372 LEU A CD1 1 ATOM 282 C CD2 . LEU A 1 48 ? 94.864 -33.995 38.556 1.00 39.79 ? 372 LEU A CD2 1 ATOM 283 N N . THR A 1 49 ? 90.239 -32.109 38.324 1.00 34.70 ? 373 THR A N 1 ATOM 284 C CA . THR A 1 49 ? 88.978 -31.396 38.157 1.00 34.80 ? 373 THR A CA 1 ATOM 285 C C . THR A 1 49 ? 89.075 -29.972 38.708 1.00 33.76 ? 373 THR A C 1 ATOM 286 O O . THR A 1 49 ? 89.558 -29.756 39.826 1.00 32.14 ? 373 THR A O 1 ATOM 287 C CB . THR A 1 49 ? 87.871 -32.116 38.930 1.00 35.85 ? 373 THR A CB 1 ATOM 288 O OG1 . THR A 1 49 ? 87.590 -33.358 38.272 1.00 36.12 ? 373 THR A OG1 1 ATOM 289 C CG2 . THR A 1 49 ? 86.607 -31.258 39.003 1.00 36.50 ? 373 THR A CG2 1 ATOM 290 N N . TRP A 1 50 ? 88.605 -29.010 37.919 1.00 32.47 ? 374 TRP A N 1 ATOM 291 C CA . TRP A 1 50 ? 88.821 -27.593 38.195 1.00 29.92 ? 374 TRP A CA 1 ATOM 292 C C . TRP A 1 50 ? 87.564 -26.906 38.718 1.00 29.99 ? 374 TRP A C 1 ATOM 293 O O . TRP A 1 50 ? 86.439 -27.276 38.369 1.00 30.00 ? 374 TRP A O 1 ATOM 294 C CB . TRP A 1 50 ? 89.234 -26.877 36.913 1.00 29.22 ? 374 TRP A CB 1 ATOM 295 C CG . TRP A 1 50 ? 90.581 -27.214 36.360 1.00 28.71 ? 374 TRP A CG 1 ATOM 296 C CD1 . TRP A 1 50 ? 90.846 -28.057 35.330 1.00 30.03 ? 374 TRP A CD1 1 ATOM 297 C CD2 . TRP A 1 50 ? 91.839 -26.687 36.772 1.00 26.82 ? 374 TRP A CD2 1 ATOM 298 N NE1 . TRP A 1 50 ? 92.196 -28.104 35.086 1.00 28.60 ? 374 TRP A NE1 1 ATOM 299 C CE2 . TRP A 1 50 ? 92.826 -27.279 35.971 1.00 28.01 ? 374 TRP A CE2 1 ATOM 300 C CE3 . TRP A 1 50 ? 92.231 -25.795 37.758 1.00 26.75 ? 374 TRP A CE3 1 ATOM 301 C CZ2 . TRP A 1 50 ? 94.184 -26.982 36.106 1.00 29.14 ? 374 TRP A CZ2 1 ATOM 302 C CZ3 . TRP A 1 50 ? 93.586 -25.504 37.900 1.00 27.60 ? 374 TRP A CZ3 1 ATOM 303 C CH2 . TRP A 1 50 ? 94.541 -26.088 37.081 1.00 27.56 ? 374 TRP A CH2 1 ATOM 304 N N . SER A 1 51 ? 87.752 -25.886 39.550 1.00 27.97 ? 375 SER A N 1 ATOM 305 C CA . SER A 1 51 ? 86.621 -25.077 39.974 1.00 26.95 ? 375 SER A CA 1 ATOM 306 C C . SER A 1 51 ? 87.082 -23.686 40.333 1.00 26.41 ? 375 SER A C 1 ATOM 307 O O . SER A 1 51 ? 88.261 -23.426 40.346 1.00 25.89 ? 375 SER A O 1 ATOM 308 C CB . SER A 1 51 ? 85.879 -25.719 41.147 1.00 27.63 ? 375 SER A CB 1 ATOM 309 O OG . SER A 1 51 ? 86.670 -25.835 42.321 1.00 28.17 ? 375 SER A OG 1 ATOM 310 N N . ARG A 1 52 ? 86.143 -22.798 40.623 1.00 28.16 ? 376 ARG A N 1 ATOM 311 C CA . ARG A 1 52 ? 86.451 -21.453 41.080 1.00 29.34 ? 376 ARG A CA 1 ATOM 312 C C . ARG A 1 52 ? 85.827 -21.250 42.451 1.00 29.37 ? 376 ARG A C 1 ATOM 313 O O . ARG A 1 52 ? 84.718 -21.708 42.723 1.00 31.32 ? 376 ARG A O 1 ATOM 314 C CB . ARG A 1 52 ? 85.867 -20.394 40.139 1.00 30.80 ? 376 ARG A CB 1 ATOM 315 C CG . ARG A 1 52 ? 86.553 -20.220 38.814 1.00 32.24 ? 376 ARG A CG 1 ATOM 316 C CD . ARG A 1 52 ? 86.450 -18.759 38.360 1.00 33.33 ? 376 ARG A CD 1 ATOM 317 N NE . ARG A 1 52 ? 85.578 -18.633 37.212 1.00 34.00 ? 376 ARG A NE 1 ATOM 318 C CZ . ARG A 1 52 ? 85.064 -17.500 36.754 1.00 34.70 ? 376 ARG A CZ 1 ATOM 319 N NH1 . ARG A 1 52 ? 85.296 -16.331 37.342 1.00 33.08 ? 376 ARG A NH1 1 ATOM 320 N NH2 . ARG A 1 52 ? 84.288 -17.568 35.679 1.00 36.06 ? 376 ARG A NH2 1 ATOM 321 N N . ALA A 1 53 ? 86.502 -20.516 43.322 1.00 28.03 ? 377 ALA A N 1 ATOM 322 C CA . ALA A 1 53 ? 85.980 -20.355 44.659 1.00 25.47 ? 377 ALA A CA 1 ATOM 323 C C . ALA A 1 53 ? 84.631 -19.658 44.586 1.00 25.72 ? 377 ALA A C 1 ATOM 324 O O . ALA A 1 53 ? 83.740 -19.901 45.409 1.00 27.07 ? 377 ALA A O 1 ATOM 325 C CB . ALA A 1 53 ? 86.957 -19.563 45.481 1.00 24.88 ? 377 ALA A CB 1 ATOM 326 N N . SER A 1 54 ? 84.480 -18.771 43.607 1.00 25.22 ? 378 SER A N 1 ATOM 327 C CA . SER A 1 54 ? 83.211 -18.088 43.383 1.00 24.06 ? 378 SER A CA 1 ATOM 328 C C . SER A 1 54 ? 82.098 -19.035 42.928 1.00 24.33 ? 378 SER A C 1 ATOM 329 O O . SER A 1 54 ? 80.922 -18.712 43.037 1.00 23.92 ? 378 SER A O 1 ATOM 330 C CB . SER A 1 54 ? 83.400 -17.012 42.319 1.00 24.27 ? 378 SER A CB 1 ATOM 331 O OG . SER A 1 54 ? 83.819 -17.581 41.085 1.00 23.20 ? 378 SER A OG 1 ATOM 332 N N . GLY A 1 55 ? 82.449 -20.208 42.405 1.00 25.41 ? 379 GLY A N 1 ATOM 333 C CA . GLY A 1 55 ? 81.435 -21.112 41.840 1.00 25.40 ? 379 GLY A CA 1 ATOM 334 C C . GLY A 1 55 ? 81.063 -20.855 40.381 1.00 24.90 ? 379 GLY A C 1 ATOM 335 O O . GLY A 1 55 ? 80.208 -21.530 39.836 1.00 27.89 ? 379 GLY A O 1 ATOM 336 N N . LYS A 1 56 ? 81.697 -19.884 39.741 1.00 24.37 ? 380 LYS A N 1 ATOM 337 C CA . LYS A 1 56 ? 81.465 -19.619 38.336 1.00 26.50 ? 380 LYS A CA 1 ATOM 338 C C . LYS A 1 56 ? 82.164 -20.622 37.392 1.00 27.63 ? 380 LYS A C 1 ATOM 339 O O . LYS A 1 56 ? 83.081 -21.355 37.785 1.00 24.33 ? 380 LYS A O 1 ATOM 340 C CB . LYS A 1 56 ? 81.910 -18.196 38.013 1.00 27.08 ? 380 LYS A CB 1 ATOM 341 C CG . LYS A 1 56 ? 81.120 -17.155 38.757 1.00 27.72 ? 380 LYS A CG 1 ATOM 342 C CD . LYS A 1 56 ? 81.638 -15.758 38.460 1.00 29.33 ? 380 LYS A CD 1 ATOM 343 C CE . LYS A 1 56 ? 80.717 -14.709 39.079 1.00 30.64 ? 380 LYS A CE 1 ATOM 344 N NZ . LYS A 1 56 ? 81.305 -13.355 38.982 1.00 32.07 ? 380 LYS A NZ 1 ATOM 345 N N . PRO A 1 57 ? 81.703 -20.649 36.130 1.00 29.46 ? 381 PRO A N 1 ATOM 346 C CA . PRO A 1 57 ? 82.098 -21.629 35.141 1.00 29.08 ? 381 PRO A CA 1 ATOM 347 C C . PRO A 1 57 ? 83.566 -21.532 34.869 1.00 29.45 ? 381 PRO A C 1 ATOM 348 O O . PRO A 1 57 ? 84.127 -20.439 34.921 1.00 31.08 ? 381 PRO A O 1 ATOM 349 C CB . PRO A 1 57 ? 81.320 -21.209 33.898 1.00 29.61 ? 381 PRO A CB 1 ATOM 350 C CG . PRO A 1 57 ? 80.085 -20.560 34.441 1.00 30.37 ? 381 PRO A CG 1 ATOM 351 C CD . PRO A 1 57 ? 80.587 -19.810 35.646 1.00 30.52 ? 381 PRO A CD 1 ATOM 352 N N . VAL A 1 58 ? 84.164 -22.684 34.598 1.00 28.53 ? 382 VAL A N 1 ATOM 353 C CA . VAL A 1 58 ? 85.543 -22.764 34.189 1.00 29.18 ? 382 VAL A CA 1 ATOM 354 C C . VAL A 1 58 ? 85.588 -23.198 32.727 1.00 30.22 ? 382 VAL A C 1 ATOM 355 O O . VAL A 1 58 ? 84.683 -23.883 32.252 1.00 30.29 ? 382 VAL A O 1 ATOM 356 C CB . VAL A 1 58 ? 86.305 -23.788 35.034 1.00 29.09 ? 382 VAL A CB 1 ATOM 357 C CG1 . VAL A 1 58 ? 86.400 -23.294 36.480 1.00 27.52 ? 382 VAL A CG1 1 ATOM 358 C CG2 . VAL A 1 58 ? 85.636 -25.198 34.917 1.00 27.90 ? 382 VAL A CG2 1 ATOM 359 N N . GLN A 1 59 ? 86.625 -22.784 32.014 1.00 30.23 ? 383 GLN A N 1 ATOM 360 C CA . GLN A 1 59 ? 86.732 -23.121 30.607 1.00 33.67 ? 383 GLN A CA 1 ATOM 361 C C . GLN A 1 59 ? 87.204 -24.566 30.443 1.00 32.99 ? 383 GLN A C 1 ATOM 362 O O . GLN A 1 59 ? 87.537 -25.233 31.412 1.00 31.59 ? 383 GLN A O 1 ATOM 363 C CB . GLN A 1 59 ? 87.662 -22.132 29.897 1.00 36.10 ? 383 GLN A CB 1 ATOM 364 C CG . GLN A 1 59 ? 87.181 -20.689 29.983 1.00 37.42 ? 383 GLN A CG 1 ATOM 365 C CD . GLN A 1 59 ? 88.058 -19.713 29.195 1.00 40.66 ? 383 GLN A CD 1 ATOM 366 O OE1 . GLN A 1 59 ? 88.642 -20.073 28.162 1.00 43.44 ? 383 GLN A OE1 1 ATOM 367 N NE2 . GLN A 1 59 ? 88.145 -18.468 29.669 1.00 39.91 ? 383 GLN A NE2 1 ATOM 368 N N . HIS A 1 60 ? 87.201 -25.076 29.222 1.00 34.77 ? 384 HIS A N 1 ATOM 369 C CA . HIS A 1 60 ? 87.727 -26.433 28.978 1.00 34.94 ? 384 HIS A CA 1 ATOM 370 C C . HIS A 1 60 ? 89.242 -26.474 29.197 1.00 33.88 ? 384 HIS A C 1 ATOM 371 O O . HIS A 1 60 ? 89.957 -25.546 28.832 1.00 31.41 ? 384 HIS A O 1 ATOM 372 C CB . HIS A 1 60 ? 87.374 -26.895 27.560 1.00 34.60 ? 384 HIS A CB 1 ATOM 373 C CG . HIS A 1 60 ? 85.918 -27.175 27.375 1.00 35.25 ? 384 HIS A CG 1 ATOM 374 N ND1 . HIS A 1 60 ? 85.212 -28.022 28.208 1.00 35.77 ? 384 HIS A ND1 1 ATOM 375 C CD2 . HIS A 1 60 ? 85.029 -26.711 26.466 1.00 35.77 ? 384 HIS A CD2 1 ATOM 376 C CE1 . HIS A 1 60 ? 83.952 -28.073 27.812 1.00 35.70 ? 384 HIS A CE1 1 ATOM 377 N NE2 . HIS A 1 60 ? 83.814 -27.286 26.759 1.00 35.63 ? 384 HIS A NE2 1 ATOM 378 N N . SER A 1 61 ? 89.725 -27.542 29.819 1.00 35.19 ? 385 SER A N 1 ATOM 379 C CA . SER A 1 61 ? 91.166 -27.708 30.087 1.00 36.04 ? 385 SER A CA 1 ATOM 380 C C . SER A 1 61 ? 91.877 -28.747 29.186 1.00 36.15 ? 385 SER A C 1 ATOM 381 O O . SER A 1 61 ? 91.258 -29.628 28.624 1.00 35.77 ? 385 SER A O 1 ATOM 382 C CB . SER A 1 61 ? 91.347 -28.126 31.536 1.00 34.96 ? 385 SER A CB 1 ATOM 383 O OG . SER A 1 61 ? 90.700 -29.361 31.725 1.00 36.85 ? 385 SER A OG 1 ATOM 384 N N . THR A 1 62 ? 93.192 -28.645 29.073 1.00 37.17 ? 386 THR A N 1 ATOM 385 C CA . THR A 1 62 ? 93.979 -29.627 28.356 1.00 38.47 ? 386 THR A CA 1 ATOM 386 C C . THR A 1 62 ? 94.680 -30.558 29.321 1.00 38.44 ? 386 THR A C 1 ATOM 387 O O . THR A 1 62 ? 95.471 -30.095 30.123 1.00 36.03 ? 386 THR A O 1 ATOM 388 C CB . THR A 1 62 ? 95.065 -28.943 27.530 1.00 39.95 ? 386 THR A CB 1 ATOM 389 O OG1 . THR A 1 62 ? 94.439 -28.028 26.618 1.00 42.01 ? 386 THR A OG1 1 ATOM 390 C CG2 . THR A 1 62 ? 95.874 -29.989 26.756 1.00 40.27 ? 386 THR A CG2 1 ATOM 391 N N . ARG A 1 63 ? 94.391 -31.857 29.233 1.00 40.59 ? 387 ARG A N 1 ATOM 392 C CA . ARG A 1 63 ? 95.091 -32.882 30.017 1.00 41.65 ? 387 ARG A CA 1 ATOM 393 C C . ARG A 1 63 ? 96.219 -33.522 29.218 1.00 43.42 ? 387 ARG A C 1 ATOM 394 O O . ARG A 1 63 ? 96.136 -33.640 28.000 1.00 43.08 ? 387 ARG A O 1 ATOM 395 C CB . ARG A 1 63 ? 94.120 -33.966 30.461 1.00 42.44 ? 387 ARG A CB 1 ATOM 396 C CG . ARG A 1 63 ? 94.664 -34.925 31.518 1.00 43.14 ? 387 ARG A CG 1 ATOM 397 C CD . ARG A 1 63 ? 93.697 -36.089 31.676 1.00 43.99 ? 387 ARG A CD 1 ATOM 398 N NE . ARG A 1 63 ? 94.286 -37.323 32.188 1.00 44.97 ? 387 ARG A NE 1 ATOM 399 C CZ . ARG A 1 63 ? 94.617 -37.513 33.459 1.00 46.21 ? 387 ARG A CZ 1 ATOM 400 N NH1 . ARG A 1 63 ? 94.448 -36.542 34.336 1.00 47.30 ? 387 ARG A NH1 1 ATOM 401 N NH2 . ARG A 1 63 ? 95.127 -38.667 33.859 1.00 47.20 ? 387 ARG A NH2 1 ATOM 402 N N . LYS A 1 64 ? 97.281 -33.925 29.906 1.00 45.17 ? 388 LYS A N 1 ATOM 403 C CA . LYS A 1 64 ? 98.487 -34.395 29.239 1.00 46.90 ? 388 LYS A CA 1 ATOM 404 C C . LYS A 1 64 ? 99.239 -35.355 30.168 1.00 48.10 ? 388 LYS A C 1 ATOM 405 O O . LYS A 1 64 ? 99.441 -35.033 31.340 1.00 48.98 ? 388 LYS A O 1 ATOM 406 C CB . LYS A 1 64 ? 99.356 -33.195 28.854 1.00 47.76 ? 388 LYS A CB 1 ATOM 407 C CG . LYS A 1 64 ? 100.554 -33.536 27.993 1.00 49.25 ? 388 LYS A CG 1 ATOM 408 C CD . LYS A 1 64 ? 101.329 -32.288 27.586 1.00 50.96 ? 388 LYS A CD 1 ATOM 409 C CE . LYS A 1 64 ? 102.260 -32.583 26.407 1.00 51.86 ? 388 LYS A CE 1 ATOM 410 N NZ . LYS A 1 64 ? 102.963 -31.375 25.892 1.00 52.34 ? 388 LYS A NZ 1 ATOM 411 N N . GLU A 1 65 ? 99.625 -36.528 29.660 1.00 47.95 ? 389 GLU A N 1 ATOM 412 C CA . GLU A 1 65 ? 100.329 -37.536 30.459 1.00 49.41 ? 389 GLU A CA 1 ATOM 413 C C . GLU A 1 65 ? 101.571 -38.066 29.750 1.00 49.82 ? 389 GLU A C 1 ATOM 414 O O . GLU A 1 65 ? 101.570 -38.230 28.533 1.00 49.76 ? 389 GLU A O 1 ATOM 415 C CB . GLU A 1 65 ? 99.453 -38.762 30.713 1.00 49.97 ? 389 GLU A CB 1 ATOM 416 C CG . GLU A 1 65 ? 98.119 -38.512 31.358 1.00 51.48 ? 389 GLU A CG 1 ATOM 417 C CD . GLU A 1 65 ? 97.289 -39.781 31.410 1.00 51.85 ? 389 GLU A CD 1 ATOM 418 O OE1 . GLU A 1 65 ? 97.876 -40.857 31.673 1.00 50.86 ? 389 GLU A OE1 1 ATOM 419 O OE2 . GLU A 1 65 ? 96.062 -39.692 31.174 1.00 52.19 ? 389 GLU A OE2 1 ATOM 420 N N . GLU A 1 66 ? 102.612 -38.374 30.517 1.00 49.88 ? 390 GLU A N 1 ATOM 421 C CA . GLU A 1 66 ? 103.833 -38.955 29.959 1.00 50.62 ? 390 GLU A CA 1 ATOM 422 C C . GLU A 1 66 ? 104.569 -39.757 31.035 1.00 49.00 ? 390 GLU A C 1 ATOM 423 O O . GLU A 1 66 ? 104.982 -39.216 32.060 1.00 45.46 ? 390 GLU A O 1 ATOM 424 C CB . GLU A 1 66 ? 104.739 -37.845 29.408 1.00 52.46 ? 390 GLU A CB 1 ATOM 425 C CG . GLU A 1 66 ? 104.697 -36.605 30.305 1.00 54.10 ? 390 GLU A CG 1 ATOM 426 C CD . GLU A 1 66 ? 105.506 -35.419 29.820 1.00 54.97 ? 390 GLU A CD 1 ATOM 427 O OE1 . GLU A 1 66 ? 105.122 -34.286 30.225 1.00 56.14 ? 390 GLU A OE1 1 ATOM 428 O OE2 . GLU A 1 66 ? 106.494 -35.624 29.070 1.00 54.53 ? 390 GLU A OE2 1 ATOM 429 N N . LYS A 1 67 ? 104.730 -41.057 30.806 1.00 49.39 ? 391 LYS A N 1 ATOM 430 C CA . LYS A 1 67 ? 105.628 -41.844 31.638 1.00 48.96 ? 391 LYS A CA 1 ATOM 431 C C . LYS A 1 67 ? 107.028 -41.340 31.354 1.00 48.44 ? 391 LYS A C 1 ATOM 432 O O . LYS A 1 67 ? 107.430 -41.243 30.197 1.00 46.76 ? 391 LYS A O 1 ATOM 433 C CB . LYS A 1 67 ? 105.506 -43.336 31.346 1.00 49.77 ? 391 LYS A CB 1 ATOM 434 C CG . LYS A 1 67 ? 104.297 -43.969 32.010 1.00 50.68 ? 391 LYS A CG 1 ATOM 435 C CD . LYS A 1 67 ? 104.336 -45.487 31.955 1.00 51.56 ? 391 LYS A CD 1 ATOM 436 C CE . LYS A 1 67 ? 105.337 -46.074 32.954 1.00 52.07 ? 391 LYS A CE 1 ATOM 437 N NZ . LYS A 1 67 ? 106.707 -46.272 32.369 1.00 52.07 ? 391 LYS A NZ 1 ATOM 438 N N . GLN A 1 68 ? 107.743 -40.991 32.419 1.00 49.13 ? 392 GLN A N 1 ATOM 439 C CA . GLN A 1 68 ? 109.065 -40.403 32.304 1.00 50.02 ? 392 GLN A CA 1 ATOM 440 C C . GLN A 1 68 ? 110.096 -41.517 32.213 1.00 51.11 ? 392 GLN A C 1 ATOM 441 O O . GLN A 1 68 ? 109.774 -42.691 32.395 1.00 49.66 ? 392 GLN A O 1 ATOM 442 C CB . GLN A 1 68 ? 109.375 -39.527 33.522 1.00 50.56 ? 392 GLN A CB 1 ATOM 443 C CG . GLN A 1 68 ? 108.478 -38.292 33.699 1.00 50.95 ? 392 GLN A CG 1 ATOM 444 C CD . GLN A 1 68 ? 108.767 -37.184 32.695 1.00 50.80 ? 392 GLN A CD 1 ATOM 445 O OE1 . GLN A 1 68 ? 109.842 -37.120 32.100 1.00 50.60 ? 392 GLN A OE1 1 ATOM 446 N NE2 . GLN A 1 68 ? 107.798 -36.304 32.505 1.00 51.09 ? 392 GLN A NE2 1 ATOM 447 N N . ARG A 1 69 ? 111.338 -41.124 31.947 1.00 52.66 ? 393 ARG A N 1 ATOM 448 C CA . ARG A 1 69 ? 112.450 -42.054 31.795 1.00 53.83 ? 393 ARG A CA 1 ATOM 449 C C . ARG A 1 69 ? 112.784 -42.826 33.075 1.00 53.28 ? 393 ARG A C 1 ATOM 450 O O . ARG A 1 69 ? 113.267 -43.952 33.002 1.00 53.76 ? 393 ARG A O 1 ATOM 451 C CB . ARG A 1 69 ? 113.695 -41.295 31.312 1.00 55.16 ? 393 ARG A CB 1 ATOM 452 C CG . ARG A 1 69 ? 114.407 -41.943 30.127 1.00 56.15 ? 393 ARG A CG 1 ATOM 453 C CD . ARG A 1 69 ? 113.656 -41.745 28.805 1.00 56.98 ? 393 ARG A CD 1 ATOM 454 N NE . ARG A 1 69 ? 114.368 -42.350 27.676 1.00 57.75 ? 393 ARG A NE 1 ATOM 455 C CZ . ARG A 1 69 ? 113.933 -42.363 26.416 1.00 58.20 ? 393 ARG A CZ 1 ATOM 456 N NH1 . ARG A 1 69 ? 112.774 -41.803 26.094 1.00 58.50 ? 393 ARG A NH1 1 ATOM 457 N NH2 . ARG A 1 69 ? 114.663 -42.938 25.465 1.00 58.51 ? 393 ARG A NH2 1 ATOM 458 N N . ASN A 1 70 ? 112.537 -42.233 34.239 1.00 52.60 ? 394 ASN A N 1 ATOM 459 C CA . ASN A 1 70 ? 112.871 -42.878 35.507 1.00 52.15 ? 394 ASN A CA 1 ATOM 460 C C . ASN A 1 70 ? 111.676 -43.563 36.167 1.00 50.83 ? 394 ASN A C 1 ATOM 461 O O . ASN A 1 70 ? 111.627 -43.700 37.384 1.00 49.77 ? 394 ASN A O 1 ATOM 462 C CB . ASN A 1 70 ? 113.446 -41.846 36.473 1.00 53.36 ? 394 ASN A CB 1 ATOM 463 C CG . ASN A 1 70 ? 112.439 -40.777 36.829 1.00 54.04 ? 394 ASN A CG 1 ATOM 464 O OD1 . ASN A 1 70 ? 111.317 -40.803 36.329 1.00 53.92 ? 394 ASN A OD1 1 ATOM 465 N ND2 . ASN A 1 70 ? 112.833 -39.836 37.692 1.00 55.69 ? 394 ASN A ND2 1 ATOM 466 N N . GLY A 1 71 ? 110.705 -43.979 35.365 1.00 50.19 ? 395 GLY A N 1 ATOM 467 C CA . GLY A 1 71 ? 109.574 -44.748 35.866 1.00 49.47 ? 395 GLY A CA 1 ATOM 468 C C . GLY A 1 71 ? 108.393 -43.927 36.362 1.00 49.70 ? 395 GLY A C 1 ATOM 469 O O . GLY A 1 71 ? 107.322 -44.487 36.610 1.00 50.91 ? 395 GLY A O 1 ATOM 470 N N . THR A 1 72 ? 108.561 -42.610 36.505 1.00 48.55 ? 396 THR A N 1 ATOM 471 C CA . THR A 1 72 ? 107.510 -41.751 37.064 1.00 46.87 ? 396 THR A CA 1 ATOM 472 C C . THR A 1 72 ? 106.436 -41.396 36.035 1.00 45.78 ? 396 THR A C 1 ATOM 473 O O . THR A 1 72 ? 106.743 -41.134 34.873 1.00 45.88 ? 396 THR A O 1 ATOM 474 C CB . THR A 1 72 ? 108.097 -40.431 37.605 1.00 46.85 ? 396 THR A CB 1 ATOM 475 O OG1 . THR A 1 72 ? 109.060 -40.706 38.629 1.00 46.03 ? 396 THR A OG1 1 ATOM 476 C CG2 . THR A 1 72 ? 106.994 -39.535 38.171 1.00 47.11 ? 396 THR A CG2 1 ATOM 477 N N . LEU A 1 73 ? 105.177 -41.389 36.461 1.00 44.64 ? 397 LEU A N 1 ATOM 478 C CA . LEU A 1 73 ? 104.101 -40.802 35.662 1.00 43.64 ? 397 LEU A CA 1 ATOM 479 C C . LEU A 1 73 ? 103.980 -39.310 35.973 1.00 43.16 ? 397 LEU A C 1 ATOM 480 O O . LEU A 1 73 ? 104.136 -38.880 37.119 1.00 43.17 ? 397 LEU A O 1 ATOM 481 C CB . LEU A 1 73 ? 102.763 -41.485 35.949 1.00 43.59 ? 397 LEU A CB 1 ATOM 482 C CG . LEU A 1 73 ? 101.600 -41.102 35.026 1.00 43.55 ? 397 LEU A CG 1 ATOM 483 C CD1 . LEU A 1 73 ? 101.953 -41.451 33.594 1.00 43.50 ? 397 LEU A CD1 1 ATOM 484 C CD2 . LEU A 1 73 ? 100.277 -41.771 35.417 1.00 42.80 ? 397 LEU A CD2 1 ATOM 485 N N . THR A 1 74 ? 103.708 -38.527 34.935 1.00 41.92 ? 398 THR A N 1 ATOM 486 C CA . THR A 1 74 ? 103.515 -37.093 35.056 1.00 40.41 ? 398 THR A CA 1 ATOM 487 C C . THR A 1 74 ? 102.203 -36.751 34.355 1.00 40.09 ? 398 THR A C 1 ATOM 488 O O . THR A 1 74 ? 102.032 -37.004 33.160 1.00 39.46 ? 398 THR A O 1 ATOM 489 C CB . THR A 1 74 ? 104.671 -36.312 34.395 1.00 41.46 ? 398 THR A CB 1 ATOM 490 O OG1 . THR A 1 74 ? 105.852 -36.411 35.201 1.00 42.64 ? 398 THR A OG1 1 ATOM 491 C CG2 . THR A 1 74 ? 104.324 -34.841 34.230 1.00 42.54 ? 398 THR A CG2 1 ATOM 492 N N . VAL A 1 75 ? 101.273 -36.177 35.113 1.00 39.85 ? 399 VAL A N 1 ATOM 493 C CA . VAL A 1 75 ? 100.009 -35.692 34.574 1.00 38.51 ? 399 VAL A CA 1 ATOM 494 C C . VAL A 1 75 ? 99.918 -34.192 34.790 1.00 38.63 ? 399 VAL A C 1 ATOM 495 O O . VAL A 1 75 ? 100.176 -33.728 35.886 1.00 39.86 ? 399 VAL A O 1 ATOM 496 C CB . VAL A 1 75 ? 98.838 -36.315 35.314 1.00 37.08 ? 399 VAL A CB 1 ATOM 497 C CG1 . VAL A 1 75 ? 97.528 -35.714 34.812 1.00 37.09 ? 399 VAL A CG1 1 ATOM 498 C CG2 . VAL A 1 75 ? 98.874 -37.805 35.136 1.00 36.23 ? 399 VAL A CG2 1 ATOM 499 N N . THR A 1 76 ? 99.568 -33.423 33.767 1.00 37.99 ? 400 THR A N 1 ATOM 500 C CA . THR A 1 76 ? 99.301 -32.010 33.979 1.00 38.22 ? 400 THR A CA 1 ATOM 501 C C . THR A 1 76 ? 97.942 -31.693 33.381 1.00 38.84 ? 400 THR A C 1 ATOM 502 O O . THR A 1 76 ? 97.484 -32.369 32.464 1.00 38.97 ? 400 THR A O 1 ATOM 503 C CB . THR A 1 76 ? 100.266 -31.070 33.265 1.00 37.47 ? 400 THR A CB 1 ATOM 504 O OG1 . THR A 1 76 ? 99.949 -31.113 31.875 1.00 38.47 ? 400 THR A OG1 1 ATOM 505 C CG2 . THR A 1 76 ? 101.715 -31.442 33.504 1.00 37.80 ? 400 THR A CG2 1 ATOM 506 N N . SER A 1 77 ? 97.296 -30.657 33.905 1.00 38.30 ? 401 SER A N 1 ATOM 507 C CA . SER A 1 77 ? 96.097 -30.146 33.279 1.00 36.40 ? 401 SER A CA 1 ATOM 508 C C . SER A 1 77 ? 96.284 -28.652 33.233 1.00 34.93 ? 401 SER A C 1 ATOM 509 O O . SER A 1 77 ? 96.759 -28.061 34.205 1.00 34.89 ? 401 SER A O 1 ATOM 510 C CB . SER A 1 77 ? 94.855 -30.518 34.071 1.00 37.41 ? 401 SER A CB 1 ATOM 511 O OG . SER A 1 77 ? 93.707 -30.005 33.402 1.00 39.64 ? 401 SER A OG 1 ATOM 512 N N . THR A 1 78 ? 95.946 -28.053 32.096 1.00 32.61 ? 402 THR A N 1 ATOM 513 C CA . THR A 1 78 ? 96.136 -26.626 31.896 1.00 30.93 ? 402 THR A CA 1 ATOM 514 C C . THR A 1 78 ? 94.787 -26.029 31.604 1.00 30.20 ? 402 THR A C 1 ATOM 515 O O . THR A 1 78 ? 94.073 -26.503 30.721 1.00 28.38 ? 402 THR A O 1 ATOM 516 C CB . THR A 1 78 ? 97.047 -26.345 30.728 1.00 30.97 ? 402 THR A CB 1 ATOM 517 O OG1 . THR A 1 78 ? 98.300 -26.953 31.000 1.00 32.44 ? 402 THR A OG1 1 ATOM 518 C CG2 . THR A 1 78 ? 97.259 -24.856 30.533 1.00 32.13 ? 402 THR A CG2 1 ATOM 519 N N . LEU A 1 79 ? 94.460 -24.988 32.365 1.00 30.00 ? 403 LEU A N 1 ATOM 520 C CA . LEU A 1 79 ? 93.165 -24.339 32.322 1.00 28.11 ? 403 LEU A CA 1 ATOM 521 C C . LEU A 1 79 ? 93.334 -22.896 31.937 1.00 28.76 ? 403 LEU A C 1 ATOM 522 O O . LEU A 1 79 ? 93.987 -22.145 32.659 1.00 29.30 ? 403 LEU A O 1 ATOM 523 C CB . LEU A 1 79 ? 92.553 -24.331 33.707 1.00 27.49 ? 403 LEU A CB 1 ATOM 524 C CG . LEU A 1 79 ? 91.205 -23.609 33.810 1.00 27.90 ? 403 LEU A CG 1 ATOM 525 C CD1 . LEU A 1 79 ? 90.115 -24.383 33.016 1.00 23.32 ? 403 LEU A CD1 1 ATOM 526 C CD2 . LEU A 1 79 ? 90.833 -23.408 35.318 1.00 25.55 ? 403 LEU A CD2 1 ATOM 527 N N . PRO A 1 80 ? 92.719 -22.498 30.823 1.00 27.17 ? 404 PRO A N 1 ATOM 528 C CA . PRO A 1 80 ? 92.647 -21.085 30.469 1.00 27.20 ? 404 PRO A CA 1 ATOM 529 C C . PRO A 1 80 ? 91.792 -20.320 31.482 1.00 28.50 ? 404 PRO A C 1 ATOM 530 O O . PRO A 1 80 ? 90.791 -20.840 31.959 1.00 30.58 ? 404 PRO A O 1 ATOM 531 C CB . PRO A 1 80 ? 91.971 -21.100 29.078 1.00 26.99 ? 404 PRO A CB 1 ATOM 532 C CG . PRO A 1 80 ? 92.029 -22.534 28.604 1.00 26.07 ? 404 PRO A CG 1 ATOM 533 C CD . PRO A 1 80 ? 92.017 -23.360 29.860 1.00 26.16 ? 404 PRO A CD 1 ATOM 534 N N . VAL A 1 81 ? 92.183 -19.096 31.817 1.00 29.86 ? 405 VAL A N 1 ATOM 535 C CA . VAL A 1 81 ? 91.442 -18.282 32.773 1.00 30.36 ? 405 VAL A CA 1 ATOM 536 C C . VAL A 1 81 ? 91.270 -16.887 32.201 1.00 30.32 ? 405 VAL A C 1 ATOM 537 O O . VAL A 1 81 ? 92.027 -16.461 31.325 1.00 31.10 ? 405 VAL A O 1 ATOM 538 C CB . VAL A 1 81 ? 92.149 -18.208 34.163 1.00 31.77 ? 405 VAL A CB 1 ATOM 539 C CG1 . VAL A 1 81 ? 92.270 -19.613 34.766 1.00 30.17 ? 405 VAL A CG1 1 ATOM 540 C CG2 . VAL A 1 81 ? 93.529 -17.513 34.070 1.00 28.21 ? 405 VAL A CG2 1 ATOM 541 N N . GLY A 1 82 ? 90.245 -16.199 32.680 1.00 30.71 ? 406 GLY A N 1 ATOM 542 C CA . GLY A 1 82 ? 89.945 -14.848 32.241 1.00 31.12 ? 406 GLY A CA 1 ATOM 543 C C . GLY A 1 82 ? 91.018 -13.950 32.800 1.00 31.37 ? 406 GLY A C 1 ATOM 544 O O . GLY A 1 82 ? 91.607 -14.256 33.828 1.00 31.73 ? 406 GLY A O 1 ATOM 545 N N . THR A 1 83 ? 91.269 -12.847 32.115 1.00 33.23 ? 407 THR A N 1 ATOM 546 C CA . THR A 1 83 ? 92.296 -11.907 32.505 1.00 34.38 ? 407 THR A CA 1 ATOM 547 C C . THR A 1 83 ? 91.781 -11.054 33.659 1.00 35.95 ? 407 THR A C 1 ATOM 548 O O . THR A 1 83 ? 92.438 -10.929 34.699 1.00 36.23 ? 407 THR A O 1 ATOM 549 C CB . THR A 1 83 ? 92.688 -11.018 31.303 1.00 35.70 ? 407 THR A CB 1 ATOM 550 O OG1 . THR A 1 83 ? 93.300 -11.837 30.289 1.00 37.16 ? 407 THR A OG1 1 ATOM 551 C CG2 . THR A 1 83 ? 93.685 -9.920 31.725 1.00 36.59 ? 407 THR A CG2 1 ATOM 552 N N . ARG A 1 84 ? 90.594 -10.483 33.484 1.00 36.89 ? 408 ARG A N 1 ATOM 553 C CA . ARG A 1 84 ? 89.985 -9.688 34.535 1.00 37.81 ? 408 ARG A CA 1 ATOM 554 C C . ARG A 1 84 ? 89.780 -10.555 35.782 1.00 37.06 ? 408 ARG A C 1 ATOM 555 O O . ARG A 1 84 ? 90.204 -10.185 36.879 1.00 36.51 ? 408 ARG A O 1 ATOM 556 C CB . ARG A 1 84 ? 88.677 -9.077 34.043 1.00 40.35 ? 408 ARG A CB 1 ATOM 557 C CG . ARG A 1 84 ? 88.059 -8.017 34.973 1.00 44.04 ? 408 ARG A CG 1 ATOM 558 C CD . ARG A 1 84 ? 86.520 -7.982 34.859 1.00 46.50 ? 408 ARG A CD 1 ATOM 559 N NE . ARG A 1 84 ? 85.957 -9.224 35.405 1.00 49.87 ? 408 ARG A NE 1 ATOM 560 C CZ . ARG A 1 84 ? 84.663 -9.503 35.530 1.00 52.41 ? 408 ARG A CZ 1 ATOM 561 N NH1 . ARG A 1 84 ? 83.726 -8.642 35.148 1.00 53.11 ? 408 ARG A NH1 1 ATOM 562 N NH2 . ARG A 1 84 ? 84.302 -10.666 36.051 1.00 54.38 ? 408 ARG A NH2 1 ATOM 563 N N . ASP A 1 85 ? 89.154 -11.721 35.626 1.00 36.32 ? 409 ASP A N 1 ATOM 564 C CA . ASP A 1 85 ? 88.909 -12.614 36.769 1.00 35.08 ? 409 ASP A CA 1 ATOM 565 C C . ASP A 1 85 ? 90.189 -12.823 37.588 1.00 35.28 ? 409 ASP A C 1 ATOM 566 O O . ASP A 1 85 ? 90.202 -12.668 38.799 1.00 36.64 ? 409 ASP A O 1 ATOM 567 C CB . ASP A 1 85 ? 88.396 -13.980 36.310 1.00 35.13 ? 409 ASP A CB 1 ATOM 568 C CG . ASP A 1 85 ? 87.046 -13.918 35.589 1.00 35.56 ? 409 ASP A CG 1 ATOM 569 O OD1 . ASP A 1 85 ? 86.303 -12.926 35.733 1.00 34.95 ? 409 ASP A OD1 1 ATOM 570 O OD2 . ASP A 1 85 ? 86.731 -14.892 34.861 1.00 36.25 ? 409 ASP A OD2 1 ATOM 571 N N . TRP A 1 86 ? 91.279 -13.188 36.933 1.00 35.65 ? 410 TRP A N 1 ATOM 572 C CA . TRP A 1 86 ? 92.545 -13.346 37.635 1.00 35.40 ? 410 TRP A CA 1 ATOM 573 C C . TRP A 1 86 ? 93.053 -12.058 38.297 1.00 35.22 ? 410 TRP A C 1 ATOM 574 O O . TRP A 1 86 ? 93.381 -12.045 39.472 1.00 36.73 ? 410 TRP A O 1 ATOM 575 C CB . TRP A 1 86 ? 93.625 -13.889 36.707 1.00 33.37 ? 410 TRP A CB 1 ATOM 576 C CG . TRP A 1 86 ? 94.877 -14.096 37.463 1.00 33.31 ? 410 TRP A CG 1 ATOM 577 C CD1 . TRP A 1 86 ? 95.924 -13.217 37.600 1.00 33.43 ? 410 TRP A CD1 1 ATOM 578 C CD2 . TRP A 1 86 ? 95.225 -15.256 38.222 1.00 31.87 ? 410 TRP A CD2 1 ATOM 579 N NE1 . TRP A 1 86 ? 96.911 -13.779 38.395 1.00 32.69 ? 410 TRP A NE1 1 ATOM 580 C CE2 . TRP A 1 86 ? 96.494 -15.024 38.790 1.00 30.90 ? 410 TRP A CE2 1 ATOM 581 C CE3 . TRP A 1 86 ? 94.588 -16.464 38.473 1.00 31.45 ? 410 TRP A CE3 1 ATOM 582 C CZ2 . TRP A 1 86 ? 97.121 -15.948 39.587 1.00 30.21 ? 410 TRP A CZ2 1 ATOM 583 C CZ3 . TRP A 1 86 ? 95.219 -17.377 39.265 1.00 32.11 ? 410 TRP A CZ3 1 ATOM 584 C CH2 . TRP A 1 86 ? 96.475 -17.120 39.809 1.00 30.49 ? 410 TRP A CH2 1 ATOM 585 N N . ILE A 1 87 ? 93.126 -10.978 37.540 1.00 34.71 ? 411 ILE A N 1 ATOM 586 C CA . ILE A 1 87 ? 93.568 -9.705 38.078 1.00 35.15 ? 411 ILE A CA 1 ATOM 587 C C . ILE A 1 87 ? 92.735 -9.212 39.273 1.00 36.09 ? 411 ILE A C 1 ATOM 588 O O . ILE A 1 87 ? 93.258 -8.571 40.188 1.00 36.73 ? 411 ILE A O 1 ATOM 589 C CB . ILE A 1 87 ? 93.540 -8.660 36.955 1.00 35.64 ? 411 ILE A CB 1 ATOM 590 C CG1 . ILE A 1 87 ? 94.601 -9.015 35.909 1.00 35.90 ? 411 ILE A CG1 1 ATOM 591 C CG2 . ILE A 1 87 ? 93.759 -7.257 37.499 1.00 36.11 ? 411 ILE A CG2 1 ATOM 592 C CD1 . ILE A 1 87 ? 96.009 -8.848 36.399 1.00 35.95 ? 411 ILE A CD1 1 ATOM 593 N N . GLU A 1 88 ? 91.439 -9.508 39.272 1.00 35.87 ? 412 GLU A N 1 ATOM 594 C CA . GLU A 1 88 ? 90.550 -9.048 40.337 1.00 35.89 ? 412 GLU A CA 1 ATOM 595 C C . GLU A 1 88 ? 90.413 -10.039 41.510 1.00 34.05 ? 412 GLU A C 1 ATOM 596 O O . GLU A 1 88 ? 89.566 -9.854 42.406 1.00 31.80 ? 412 GLU A O 1 ATOM 597 C CB . GLU A 1 88 ? 89.186 -8.692 39.746 1.00 37.39 ? 412 GLU A CB 1 ATOM 598 C CG . GLU A 1 88 ? 89.238 -7.426 38.914 1.00 38.94 ? 412 GLU A CG 1 ATOM 599 C CD . GLU A 1 88 ? 87.882 -7.029 38.367 1.00 41.03 ? 412 GLU A CD 1 ATOM 600 O OE1 . GLU A 1 88 ? 86.893 -7.733 38.702 1.00 42.21 ? 412 GLU A OE1 1 ATOM 601 O OE2 . GLU A 1 88 ? 87.826 -6.029 37.604 1.00 40.39 ? 412 GLU A OE2 1 ATOM 602 N N . GLY A 1 89 ? 91.260 -11.074 41.496 1.00 31.69 ? 413 GLY A N 1 ATOM 603 C CA . GLY A 1 89 ? 91.567 -11.867 42.692 1.00 30.47 ? 413 GLY A CA 1 ATOM 604 C C . GLY A 1 89 ? 90.764 -13.144 42.846 1.00 29.73 ? 413 GLY A C 1 ATOM 605 O O . GLY A 1 89 ? 90.492 -13.597 43.959 1.00 29.61 ? 413 GLY A O 1 ATOM 606 N N . GLU A 1 90 ? 90.388 -13.740 41.721 1.00 30.13 ? 414 GLU A N 1 ATOM 607 C CA . GLU A 1 90 ? 89.650 -15.001 41.729 1.00 29.16 ? 414 GLU A CA 1 ATOM 608 C C . GLU A 1 90 ? 90.572 -16.159 42.129 1.00 27.62 ? 414 GLU A C 1 ATOM 609 O O . GLU A 1 90 ? 91.758 -16.139 41.868 1.00 27.38 ? 414 GLU A O 1 ATOM 610 C CB . GLU A 1 90 ? 89.020 -15.238 40.346 1.00 29.07 ? 414 GLU A CB 1 ATOM 611 C CG . GLU A 1 90 ? 88.412 -16.620 40.101 1.00 28.46 ? 414 GLU A CG 1 ATOM 612 C CD . GLU A 1 90 ? 87.203 -16.901 40.953 1.00 28.52 ? 414 GLU A CD 1 ATOM 613 O OE1 . GLU A 1 90 ? 87.402 -17.168 42.157 1.00 31.63 ? 414 GLU A OE1 1 ATOM 614 O OE2 . GLU A 1 90 ? 86.058 -16.865 40.442 1.00 26.49 ? 414 GLU A OE2 1 ATOM 615 N N . THR A 1 91 ? 90.024 -17.176 42.777 1.00 27.10 ? 415 THR A N 1 ATOM 616 C CA . THR A 1 91 ? 90.851 -18.264 43.271 1.00 26.40 ? 415 THR A CA 1 ATOM 617 C C . THR A 1 91 ? 90.439 -19.498 42.487 1.00 26.29 ? 415 THR A C 1 ATOM 618 O O . THR A 1 91 ? 89.247 -19.813 42.435 1.00 24.78 ? 415 THR A O 1 ATOM 619 C CB . THR A 1 91 ? 90.675 -18.502 44.790 1.00 25.87 ? 415 THR A CB 1 ATOM 620 O OG1 . THR A 1 91 ? 90.920 -17.289 45.503 1.00 25.93 ? 415 THR A OG1 1 ATOM 621 C CG2 . THR A 1 91 ? 91.648 -19.559 45.291 1.00 24.81 ? 415 THR A CG2 1 ATOM 622 N N . TYR A 1 92 ? 91.422 -20.165 41.868 1.00 26.58 ? 416 TYR A N 1 ATOM 623 C CA . TYR A 1 92 ? 91.182 -21.342 41.042 1.00 25.99 ? 416 TYR A CA 1 ATOM 624 C C . TYR A 1 92 ? 91.683 -22.574 41.790 1.00 27.72 ? 416 TYR A C 1 ATOM 625 O O . TYR A 1 92 ? 92.732 -22.547 42.421 1.00 28.34 ? 416 TYR A O 1 ATOM 626 C CB . TYR A 1 92 ? 91.850 -21.199 39.679 1.00 24.69 ? 416 TYR A CB 1 ATOM 627 C CG . TYR A 1 92 ? 91.304 -20.047 38.857 1.00 23.94 ? 416 TYR A CG 1 ATOM 628 C CD1 . TYR A 1 92 ? 91.711 -18.753 39.100 1.00 24.14 ? 416 TYR A CD1 1 ATOM 629 C CD2 . TYR A 1 92 ? 90.376 -20.249 37.854 1.00 25.07 ? 416 TYR A CD2 1 ATOM 630 C CE1 . TYR A 1 92 ? 91.220 -17.689 38.384 1.00 25.08 ? 416 TYR A CE1 1 ATOM 631 C CE2 . TYR A 1 92 ? 89.871 -19.190 37.125 1.00 25.84 ? 416 TYR A CE2 1 ATOM 632 C CZ . TYR A 1 92 ? 90.302 -17.901 37.396 1.00 26.12 ? 416 TYR A CZ 1 ATOM 633 O OH . TYR A 1 92 ? 89.838 -16.802 36.699 1.00 26.63 ? 416 TYR A OH 1 ATOM 634 N N . GLN A 1 93 ? 90.921 -23.655 41.720 1.00 29.03 ? 417 GLN A N 1 ATOM 635 C CA . GLN A 1 93 ? 91.169 -24.827 42.544 1.00 31.65 ? 417 GLN A CA 1 ATOM 636 C C . GLN A 1 93 ? 91.278 -26.081 41.687 1.00 33.04 ? 417 GLN A C 1 ATOM 637 O O . GLN A 1 93 ? 90.535 -26.267 40.714 1.00 34.96 ? 417 GLN A O 1 ATOM 638 C CB . GLN A 1 93 ? 90.014 -24.982 43.538 1.00 33.80 ? 417 GLN A CB 1 ATOM 639 C CG . GLN A 1 93 ? 89.718 -23.681 44.318 1.00 34.66 ? 417 GLN A CG 1 ATOM 640 C CD . GLN A 1 93 ? 88.328 -23.628 44.927 1.00 34.23 ? 417 GLN A CD 1 ATOM 641 O OE1 . GLN A 1 93 ? 87.351 -24.118 44.342 1.00 31.69 ? 417 GLN A OE1 1 ATOM 642 N NE2 . GLN A 1 93 ? 88.233 -23.008 46.113 1.00 35.19 ? 417 GLN A NE2 1 ATOM 643 N N . CYS A 1 94 ? 92.215 -26.946 42.045 1.00 34.18 ? 418 CYS A N 1 ATOM 644 C CA . CYS A 1 94 ? 92.465 -28.147 41.280 1.00 35.35 ? 418 CYS A CA 1 ATOM 645 C C . CYS A 1 94 ? 92.264 -29.302 42.241 1.00 36.59 ? 418 CYS A C 1 ATOM 646 O O . CYS A 1 94 ? 92.874 -29.326 43.310 1.00 34.54 ? 418 CYS A O 1 ATOM 647 C CB . CYS A 1 94 ? 93.886 -28.159 40.722 1.00 35.83 ? 418 CYS A CB 1 ATOM 648 S SG . CYS A 1 94 ? 94.349 -29.757 39.994 1.00 38.48 ? 418 CYS A SG 1 ATOM 649 N N . ARG A 1 95 ? 91.404 -30.244 41.863 1.00 38.82 ? 419 ARG A N 1 ATOM 650 C CA . ARG A 1 95 ? 91.147 -31.407 42.706 1.00 42.67 ? 419 ARG A CA 1 ATOM 651 C C . ARG A 1 95 ? 91.696 -32.687 42.071 1.00 42.91 ? 419 ARG A C 1 ATOM 652 O O . ARG A 1 95 ? 91.312 -33.042 40.955 1.00 43.18 ? 419 ARG A O 1 ATOM 653 C CB . ARG A 1 95 ? 89.652 -31.542 42.993 1.00 43.99 ? 419 ARG A CB 1 ATOM 654 C CG . ARG A 1 95 ? 89.361 -32.658 43.947 1.00 46.26 ? 419 ARG A CG 1 ATOM 655 C CD . ARG A 1 95 ? 87.900 -32.726 44.367 1.00 48.05 ? 419 ARG A CD 1 ATOM 656 N NE . ARG A 1 95 ? 87.737 -33.636 45.505 1.00 49.73 ? 419 ARG A NE 1 ATOM 657 C CZ . ARG A 1 95 ? 86.570 -33.998 46.030 1.00 51.68 ? 419 ARG A CZ 1 ATOM 658 N NH1 . ARG A 1 95 ? 85.428 -33.530 45.531 1.00 52.37 ? 419 ARG A NH1 1 ATOM 659 N NH2 . ARG A 1 95 ? 86.544 -34.836 47.060 1.00 52.27 ? 419 ARG A NH2 1 ATOM 660 N N . VAL A 1 96 ? 92.603 -33.356 42.784 1.00 43.48 ? 420 VAL A N 1 ATOM 661 C CA . VAL A 1 96 ? 93.249 -34.581 42.298 1.00 44.36 ? 420 VAL A CA 1 ATOM 662 C C . VAL A 1 96 ? 92.698 -35.853 42.945 1.00 46.25 ? 420 VAL A C 1 ATOM 663 O O . VAL A 1 96 ? 92.742 -36.016 44.163 1.00 45.69 ? 420 VAL A O 1 ATOM 664 C CB . VAL A 1 96 ? 94.772 -34.567 42.569 1.00 43.43 ? 420 VAL A CB 1 ATOM 665 C CG1 . VAL A 1 96 ? 95.420 -35.830 42.028 1.00 42.76 ? 420 VAL A CG1 1 ATOM 666 C CG2 . VAL A 1 96 ? 95.426 -33.351 41.954 1.00 42.06 ? 420 VAL A CG2 1 ATOM 667 N N . THR A 1 97 ? 92.209 -36.762 42.110 1.00 50.03 ? 421 THR A N 1 ATOM 668 C CA . THR A 1 97 ? 91.741 -38.079 42.545 1.00 52.32 ? 421 THR A CA 1 ATOM 669 C C . THR A 1 97 ? 92.589 -39.210 41.950 1.00 54.72 ? 421 THR A C 1 ATOM 670 O O . THR A 1 97 ? 92.543 -39.436 40.742 1.00 53.95 ? 421 THR A O 1 ATOM 671 C CB . THR A 1 97 ? 90.278 -38.272 42.105 1.00 52.26 ? 421 THR A CB 1 ATOM 672 O OG1 . THR A 1 97 ? 89.453 -37.328 42.796 1.00 52.36 ? 421 THR A OG1 1 ATOM 673 C CG2 . THR A 1 97 ? 89.795 -39.678 42.397 1.00 52.90 ? 421 THR A CG2 1 ATOM 674 N N . HIS A 1 98 ? 93.351 -39.911 42.793 1.00 58.61 ? 422 HIS A N 1 ATOM 675 C CA . HIS A 1 98 ? 94.124 -41.102 42.382 1.00 61.94 ? 422 HIS A CA 1 ATOM 676 C C . HIS A 1 98 ? 93.280 -42.360 42.589 1.00 62.59 ? 422 HIS A C 1 ATOM 677 O O . HIS A 1 98 ? 92.430 -42.401 43.473 1.00 62.10 ? 422 HIS A O 1 ATOM 678 C CB . HIS A 1 98 ? 95.445 -41.218 43.179 1.00 63.59 ? 422 HIS A CB 1 ATOM 679 C CG . HIS A 1 98 ? 96.476 -42.134 42.571 1.00 64.92 ? 422 HIS A CG 1 ATOM 680 N ND1 . HIS A 1 98 ? 96.637 -43.447 42.964 1.00 65.44 ? 422 HIS A ND1 1 ATOM 681 C CD2 . HIS A 1 98 ? 97.420 -41.916 41.621 1.00 65.75 ? 422 HIS A CD2 1 ATOM 682 C CE1 . HIS A 1 98 ? 97.618 -44.002 42.274 1.00 65.53 ? 422 HIS A CE1 1 ATOM 683 N NE2 . HIS A 1 98 ? 98.111 -43.094 41.452 1.00 65.74 ? 422 HIS A NE2 1 ATOM 684 N N . PRO A 1 99 ? 93.509 -43.393 41.764 1.00 64.26 ? 423 PRO A N 1 ATOM 685 C CA . PRO A 1 99 ? 92.810 -44.664 41.956 1.00 65.18 ? 423 PRO A CA 1 ATOM 686 C C . PRO A 1 99 ? 92.966 -45.197 43.385 1.00 66.48 ? 423 PRO A C 1 ATOM 687 O O . PRO A 1 99 ? 91.978 -45.466 44.078 1.00 65.85 ? 423 PRO A O 1 ATOM 688 C CB . PRO A 1 99 ? 93.512 -45.601 40.965 1.00 65.11 ? 423 PRO A CB 1 ATOM 689 C CG . PRO A 1 99 ? 94.098 -44.703 39.916 1.00 64.95 ? 423 PRO A CG 1 ATOM 690 C CD . PRO A 1 99 ? 94.421 -43.415 40.603 1.00 64.67 ? 423 PRO A CD 1 ATOM 691 N N . HIS A 1 100 ? 94.221 -45.343 43.798 1.00 67.79 ? 424 HIS A N 1 ATOM 692 C CA . HIS A 1 100 ? 94.579 -45.759 45.142 1.00 68.77 ? 424 HIS A CA 1 ATOM 693 C C . HIS A 1 100 ? 94.890 -44.525 45.987 1.00 68.57 ? 424 HIS A C 1 ATOM 694 O O . HIS A 1 100 ? 95.973 -44.416 46.561 1.00 67.88 ? 424 HIS A O 1 ATOM 695 C CB . HIS A 1 100 ? 95.815 -46.666 45.092 1.00 70.06 ? 424 HIS A CB 1 ATOM 696 C CG . HIS A 1 100 ? 95.634 -47.916 44.281 1.00 71.14 ? 424 HIS A CG 1 ATOM 697 N ND1 . HIS A 1 100 ? 95.016 -49.046 44.776 1.00 71.48 ? 424 HIS A ND1 1 ATOM 698 C CD2 . HIS A 1 100 ? 96.015 -48.222 43.017 1.00 71.74 ? 424 HIS A CD2 1 ATOM 699 C CE1 . HIS A 1 100 ? 95.014 -49.988 43.848 1.00 71.83 ? 424 HIS A CE1 1 ATOM 700 N NE2 . HIS A 1 100 ? 95.615 -49.514 42.771 1.00 71.95 ? 424 HIS A NE2 1 ATOM 701 N N . LEU A 1 101 ? 93.937 -43.598 46.047 1.00 69.08 ? 425 LEU A N 1 ATOM 702 C CA . LEU A 1 101 ? 94.043 -42.406 46.888 1.00 69.22 ? 425 LEU A CA 1 ATOM 703 C C . LEU A 1 101 ? 93.367 -42.636 48.237 1.00 69.09 ? 425 LEU A C 1 ATOM 704 O O . LEU A 1 101 ? 92.226 -43.100 48.287 1.00 69.38 ? 425 LEU A O 1 ATOM 705 C CB . LEU A 1 101 ? 93.355 -41.217 46.215 1.00 69.79 ? 425 LEU A CB 1 ATOM 706 C CG . LEU A 1 101 ? 91.823 -41.304 46.080 1.00 70.13 ? 425 LEU A CG 1 ATOM 707 C CD1 . LEU A 1 101 ? 91.106 -41.361 47.433 1.00 70.14 ? 425 LEU A CD1 1 ATOM 708 C CD2 . LEU A 1 101 ? 91.288 -40.140 45.253 1.00 69.96 ? 425 LEU A CD2 1 ATOM 709 N N . PRO A 1 102 ? 94.059 -42.304 49.338 1.00 68.59 ? 426 PRO A N 1 ATOM 710 C CA . PRO A 1 102 ? 93.333 -42.229 50.609 1.00 68.16 ? 426 PRO A CA 1 ATOM 711 C C . PRO A 1 102 ? 92.408 -41.007 50.624 1.00 67.00 ? 426 PRO A C 1 ATOM 712 O O . PRO A 1 102 ? 91.182 -41.161 50.659 1.00 67.22 ? 426 PRO A O 1 ATOM 713 C CB . PRO A 1 102 ? 94.448 -42.120 51.663 1.00 68.46 ? 426 PRO A CB 1 ATOM 714 C CG . PRO A 1 102 ? 95.763 -42.312 50.917 1.00 68.40 ? 426 PRO A CG 1 ATOM 715 C CD . PRO A 1 102 ? 95.492 -41.997 49.484 1.00 68.39 ? 426 PRO A CD 1 ATOM 716 N N . ARG A 1 103 ? 93.003 -39.814 50.577 1.00 65.11 ? 427 ARG A N 1 ATOM 717 C CA . ARG A 1 103 ? 92.259 -38.560 50.471 1.00 63.64 ? 427 ARG A CA 1 ATOM 718 C C . ARG A 1 103 ? 92.423 -37.967 49.079 1.00 61.37 ? 427 ARG A C 1 ATOM 719 O O . ARG A 1 103 ? 93.386 -38.264 48.366 1.00 60.81 ? 427 ARG A O 1 ATOM 720 C CB . ARG A 1 103 ? 92.759 -37.533 51.490 1.00 64.08 ? 427 ARG A CB 1 ATOM 721 C CG . ARG A 1 103 ? 93.068 -38.094 52.870 1.00 64.98 ? 427 ARG A CG 1 ATOM 722 C CD . ARG A 1 103 ? 91.864 -38.067 53.799 1.00 65.15 ? 427 ARG A CD 1 ATOM 723 N NE . ARG A 1 103 ? 92.295 -38.099 55.194 1.00 65.62 ? 427 ARG A NE 1 ATOM 724 C CZ . ARG A 1 103 ? 91.491 -37.951 56.246 1.00 65.80 ? 427 ARG A CZ 1 ATOM 725 N NH1 . ARG A 1 103 ? 90.187 -37.759 56.086 1.00 65.61 ? 427 ARG A NH1 1 ATOM 726 N NH2 . ARG A 1 103 ? 91.999 -38.000 57.473 1.00 65.90 ? 427 ARG A NH2 1 ATOM 727 N N . ALA A 1 104 ? 91.473 -37.121 48.704 1.00 58.77 ? 428 ALA A N 1 ATOM 728 C CA . ALA A 1 104 ? 91.594 -36.337 47.490 1.00 56.97 ? 428 ALA A CA 1 ATOM 729 C C . ALA A 1 104 ? 92.483 -35.129 47.780 1.00 55.32 ? 428 ALA A C 1 ATOM 730 O O . ALA A 1 104 ? 92.218 -34.387 48.727 1.00 56.49 ? 428 ALA A O 1 ATOM 731 C CB . ALA A 1 104 ? 90.222 -35.898 47.026 1.00 56.70 ? 428 ALA A CB 1 ATOM 732 N N . LEU A 1 105 ? 93.538 -34.947 46.983 1.00 52.48 ? 429 LEU A N 1 ATOM 733 C CA . LEU A 1 105 ? 94.430 -33.802 47.125 1.00 50.19 ? 429 LEU A CA 1 ATOM 734 C C . LEU A 1 105 ? 93.838 -32.543 46.487 1.00 48.60 ? 429 LEU A C 1 ATOM 735 O O . LEU A 1 105 ? 93.228 -32.594 45.418 1.00 48.26 ? 429 LEU A O 1 ATOM 736 C CB . LEU A 1 105 ? 95.767 -34.083 46.450 1.00 50.52 ? 429 LEU A CB 1 ATOM 737 C CG . LEU A 1 105 ? 96.723 -35.138 46.997 1.00 50.41 ? 429 LEU A CG 1 ATOM 738 C CD1 . LEU A 1 105 ? 97.971 -35.142 46.113 1.00 49.73 ? 429 LEU A CD1 1 ATOM 739 C CD2 . LEU A 1 105 ? 97.068 -34.863 48.455 1.00 50.88 ? 429 LEU A CD2 1 ATOM 740 N N . MET A 1 106 ? 94.036 -31.405 47.142 1.00 47.14 ? 430 MET A N 1 ATOM 741 C CA . MET A 1 106 ? 93.509 -30.136 46.647 1.00 46.02 ? 430 MET A CA 1 ATOM 742 C C . MET A 1 106 ? 94.613 -29.099 46.604 1.00 42.91 ? 430 MET A C 1 ATOM 743 O O . MET A 1 106 ? 95.481 -29.080 47.459 1.00 41.88 ? 430 MET A O 1 ATOM 744 C CB . MET A 1 106 ? 92.330 -29.673 47.501 1.00 47.45 ? 430 MET A CB 1 ATOM 745 C CG . MET A 1 106 ? 91.173 -30.662 47.394 1.00 49.84 ? 430 MET A CG 1 ATOM 746 S SD . MET A 1 106 ? 89.666 -30.289 48.304 1.00 53.19 ? 430 MET A SD 1 ATOM 747 C CE . MET A 1 106 ? 89.006 -31.944 48.597 1.00 52.55 ? 430 MET A CE 1 ATOM 748 N N . ARG A 1 107 ? 94.594 -28.265 45.574 1.00 40.40 ? 431 ARG A N 1 ATOM 749 C CA . ARG A 1 107 ? 95.573 -27.198 45.422 1.00 39.57 ? 431 ARG A CA 1 ATOM 750 C C . ARG A 1 107 ? 94.796 -26.025 44.879 1.00 37.48 ? 431 ARG A C 1 ATOM 751 O O . ARG A 1 107 ? 93.890 -26.204 44.073 1.00 36.33 ? 431 ARG A O 1 ATOM 752 C CB . ARG A 1 107 ? 96.665 -27.543 44.390 1.00 41.44 ? 431 ARG A CB 1 ATOM 753 C CG . ARG A 1 107 ? 97.410 -28.848 44.603 1.00 42.88 ? 431 ARG A CG 1 ATOM 754 C CD . ARG A 1 107 ? 98.336 -28.823 45.811 1.00 44.84 ? 431 ARG A CD 1 ATOM 755 N NE . ARG A 1 107 ? 98.477 -30.178 46.339 1.00 47.64 ? 431 ARG A NE 1 ATOM 756 C CZ . ARG A 1 107 ? 99.149 -30.510 47.436 1.00 49.24 ? 431 ARG A CZ 1 ATOM 757 N NH1 . ARG A 1 107 ? 99.772 -29.584 48.145 1.00 50.99 ? 431 ARG A NH1 1 ATOM 758 N NH2 . ARG A 1 107 ? 99.204 -31.778 47.819 1.00 49.65 ? 431 ARG A NH2 1 ATOM 759 N N . SER A 1 108 ? 95.146 -24.822 45.306 1.00 35.56 ? 432 SER A N 1 ATOM 760 C CA . SER A 1 108 ? 94.470 -23.640 44.790 1.00 33.41 ? 432 SER A CA 1 ATOM 761 C C . SER A 1 108 ? 95.522 -22.581 44.509 1.00 32.74 ? 432 SER A C 1 ATOM 762 O O . SER A 1 108 ? 96.656 -22.655 44.981 1.00 33.92 ? 432 SER A O 1 ATOM 763 C CB . SER A 1 108 ? 93.414 -23.132 45.779 1.00 31.92 ? 432 SER A CB 1 ATOM 764 O OG . SER A 1 108 ? 93.986 -22.817 47.031 1.00 31.10 ? 432 SER A OG 1 ATOM 765 N N . THR A 1 109 ? 95.159 -21.585 43.724 1.00 30.99 ? 433 THR A N 1 ATOM 766 C CA . THR A 1 109 ? 96.099 -20.529 43.424 1.00 30.56 ? 433 THR A CA 1 ATOM 767 C C . THR A 1 109 ? 95.346 -19.235 43.202 1.00 31.18 ? 433 THR A C 1 ATOM 768 O O . THR A 1 109 ? 94.180 -19.247 42.794 1.00 32.16 ? 433 THR A O 1 ATOM 769 C CB . THR A 1 109 ? 96.853 -20.816 42.134 1.00 30.83 ? 433 THR A CB 1 ATOM 770 O OG1 . THR A 1 109 ? 97.732 -19.728 41.884 1.00 29.95 ? 433 THR A OG1 1 ATOM 771 C CG2 . THR A 1 109 ? 95.882 -20.910 40.976 1.00 31.96 ? 433 THR A CG2 1 ATOM 772 N N . THR A 1 110 ? 96.008 -18.118 43.451 1.00 30.19 ? 434 THR A N 1 ATOM 773 C CA . THR A 1 110 ? 95.329 -16.845 43.363 1.00 32.23 ? 434 THR A CA 1 ATOM 774 C C . THR A 1 110 ? 96.412 -15.821 43.147 1.00 34.46 ? 434 THR A C 1 ATOM 775 O O . THR A 1 110 ? 97.580 -16.131 43.318 1.00 35.67 ? 434 THR A O 1 ATOM 776 C CB . THR A 1 110 ? 94.477 -16.543 44.639 1.00 32.03 ? 434 THR A CB 1 ATOM 777 O OG1 . THR A 1 110 ? 93.584 -15.457 44.368 1.00 32.32 ? 434 THR A OG1 1 ATOM 778 C CG2 . THR A 1 110 ? 95.346 -16.197 45.857 1.00 29.81 ? 434 THR A CG2 1 ATOM 779 N N . LYS A 1 111 ? 96.044 -14.619 42.743 1.00 38.13 ? 435 LYS A N 1 ATOM 780 C CA . LYS A 1 111 ? 97.031 -13.566 42.590 1.00 42.55 ? 435 LYS A CA 1 ATOM 781 C C . LYS A 1 111 ? 97.744 -13.341 43.935 1.00 46.08 ? 435 LYS A C 1 ATOM 782 O O . LYS A 1 111 ? 97.088 -13.274 44.985 1.00 47.22 ? 435 LYS A O 1 ATOM 783 C CB . LYS A 1 111 ? 96.330 -12.294 42.113 1.00 43.12 ? 435 LYS A CB 1 ATOM 784 C CG . LYS A 1 111 ? 97.233 -11.121 41.792 1.00 43.54 ? 435 LYS A CG 1 ATOM 785 C CD . LYS A 1 111 ? 96.369 -9.956 41.313 1.00 44.06 ? 435 LYS A CD 1 ATOM 786 C CE . LYS A 1 111 ? 97.109 -8.617 41.215 1.00 43.37 ? 435 LYS A CE 1 ATOM 787 N NZ . LYS A 1 111 ? 96.141 -7.529 40.879 1.00 41.96 ? 435 LYS A NZ 1 ATOM 788 N N . THR A 1 112 ? 99.077 -13.254 43.901 1.00 48.75 ? 436 THR A N 1 ATOM 789 C CA . THR A 1 112 ? 99.865 -12.887 45.082 1.00 50.85 ? 436 THR A CA 1 ATOM 790 C C . THR A 1 112 ? 99.847 -11.376 45.180 1.00 52.77 ? 436 THR A C 1 ATOM 791 O O . THR A 1 112 ? 100.267 -10.691 44.242 1.00 53.08 ? 436 THR A O 1 ATOM 792 C CB . THR A 1 112 ? 101.348 -13.307 44.995 1.00 50.50 ? 436 THR A CB 1 ATOM 793 O OG1 . THR A 1 112 ? 102.062 -12.392 44.146 1.00 51.35 ? 436 THR A OG1 1 ATOM 794 C CG2 . THR A 1 112 ? 101.485 -14.712 44.433 1.00 51.33 ? 436 THR A CG2 1 ATOM 795 N N . SER A 1 113 ? 99.373 -10.861 46.310 1.00 54.65 ? 437 SER A N 1 ATOM 796 C CA . SER A 1 113 ? 99.210 -9.420 46.457 1.00 56.91 ? 437 SER A CA 1 ATOM 797 C C . SER A 1 113 ? 99.970 -8.865 47.655 1.00 56.32 ? 437 SER A C 1 ATOM 798 O O . SER A 1 113 ? 99.384 -8.266 48.558 1.00 56.93 ? 437 SER A O 1 ATOM 799 C CB . SER A 1 113 ? 97.727 -9.029 46.529 1.00 58.66 ? 437 SER A CB 1 ATOM 800 O OG . SER A 1 113 ? 97.141 -9.039 45.230 1.00 60.05 ? 437 SER A OG 1 ATOM 801 N N . GLY A 1 114 ? 101.283 -9.063 47.653 1.00 54.54 ? 438 GLY A N 1 ATOM 802 C CA . GLY A 1 114 ? 102.146 -8.334 48.572 1.00 52.97 ? 438 GLY A CA 1 ATOM 803 C C . GLY A 1 114 ? 102.582 -7.018 47.951 1.00 51.14 ? 438 GLY A C 1 ATOM 804 O O . GLY A 1 114 ? 101.902 -6.485 47.079 1.00 51.46 ? 438 GLY A O 1 ATOM 805 N N . PRO A 1 115 ? 103.731 -6.487 48.388 1.00 49.23 ? 439 PRO A N 1 ATOM 806 C CA . PRO A 1 115 ? 104.247 -5.265 47.798 1.00 48.30 ? 439 PRO A CA 1 ATOM 807 C C . PRO A 1 115 ? 104.857 -5.520 46.421 1.00 47.02 ? 439 PRO A C 1 ATOM 808 O O . PRO A 1 115 ? 105.287 -6.640 46.132 1.00 47.78 ? 439 PRO A O 1 ATOM 809 C CB . PRO A 1 115 ? 105.312 -4.824 48.801 1.00 48.57 ? 439 PRO A CB 1 ATOM 810 C CG . PRO A 1 115 ? 105.788 -6.089 49.423 1.00 48.55 ? 439 PRO A CG 1 ATOM 811 C CD . PRO A 1 115 ? 104.614 -7.011 49.445 1.00 49.08 ? 439 PRO A CD 1 ATOM 812 N N . ARG A 1 116 ? 104.883 -4.474 45.598 1.00 45.14 ? 440 ARG A N 1 ATOM 813 C CA . ARG A 1 116 ? 105.409 -4.515 44.239 1.00 43.34 ? 440 ARG A CA 1 ATOM 814 C C . ARG A 1 116 ? 106.727 -3.752 44.092 1.00 39.38 ? 440 ARG A C 1 ATOM 815 O O . ARG A 1 116 ? 106.977 -2.779 44.777 1.00 39.99 ? 440 ARG A O 1 ATOM 816 C CB . ARG A 1 116 ? 104.391 -3.878 43.299 1.00 45.45 ? 440 ARG A CB 1 ATOM 817 C CG . ARG A 1 116 ? 103.142 -4.708 43.037 1.00 47.73 ? 440 ARG A CG 1 ATOM 818 C CD . ARG A 1 116 ? 102.420 -4.177 41.790 1.00 49.99 ? 440 ARG A CD 1 ATOM 819 N NE . ARG A 1 116 ? 101.152 -4.863 41.537 1.00 52.27 ? 440 ARG A NE 1 ATOM 820 C CZ . ARG A 1 116 ? 100.323 -4.585 40.528 1.00 53.85 ? 440 ARG A CZ 1 ATOM 821 N NH1 . ARG A 1 116 ? 100.603 -3.629 39.645 1.00 53.69 ? 440 ARG A NH1 1 ATOM 822 N NH2 . ARG A 1 116 ? 99.192 -5.272 40.397 1.00 54.83 ? 440 ARG A NH2 1 ATOM 823 N N . ALA A 1 117 ? 107.584 -4.177 43.180 1.00 36.24 ? 441 ALA A N 1 ATOM 824 C CA . ALA A 1 117 ? 108.769 -3.398 42.868 1.00 33.41 ? 441 ALA A CA 1 ATOM 825 C C . ALA A 1 117 ? 109.235 -3.848 41.513 1.00 32.72 ? 441 ALA A C 1 ATOM 826 O O . ALA A 1 117 ? 109.282 -5.043 41.249 1.00 33.90 ? 441 ALA A O 1 ATOM 827 C CB . ALA A 1 117 ? 109.848 -3.609 43.904 1.00 31.61 ? 441 ALA A CB 1 ATOM 828 N N . ALA A 1 118 ? 109.571 -2.890 40.659 1.00 32.75 ? 442 ALA A N 1 ATOM 829 C CA . ALA A 1 118 ? 109.977 -3.181 39.290 1.00 32.03 ? 442 ALA A CA 1 ATOM 830 C C . ALA A 1 118 ? 111.316 -3.912 39.267 1.00 30.96 ? 442 ALA A C 1 ATOM 831 O O . ALA A 1 118 ? 112.086 -3.844 40.216 1.00 29.26 ? 442 ALA A O 1 ATOM 832 C CB . ALA A 1 118 ? 110.069 -1.892 38.489 1.00 32.24 ? 442 ALA A CB 1 ATOM 833 N N . PRO A 1 119 ? 111.589 -4.632 38.174 1.00 30.16 ? 443 PRO A N 1 ATOM 834 C CA . PRO A 1 119 ? 112.875 -5.310 38.009 1.00 30.16 ? 443 PRO A CA 1 ATOM 835 C C . PRO A 1 119 ? 113.956 -4.454 37.357 1.00 29.12 ? 443 PRO A C 1 ATOM 836 O O . PRO A 1 119 ? 113.643 -3.639 36.499 1.00 28.27 ? 443 PRO A O 1 ATOM 837 C CB . PRO A 1 119 ? 112.525 -6.484 37.092 1.00 30.08 ? 443 PRO A CB 1 ATOM 838 C CG . PRO A 1 119 ? 111.401 -5.972 36.265 1.00 30.10 ? 443 PRO A CG 1 ATOM 839 C CD . PRO A 1 119 ? 110.621 -5.006 37.129 1.00 29.44 ? 443 PRO A CD 1 ATOM 840 N N . GLU A 1 120 ? 115.207 -4.666 37.760 1.00 28.16 ? 444 GLU A N 1 ATOM 841 C CA . GLU A 1 120 ? 116.364 -4.100 37.085 1.00 26.96 ? 444 GLU A CA 1 ATOM 842 C C . GLU A 1 120 ? 116.854 -5.166 36.115 1.00 25.94 ? 444 GLU A C 1 ATOM 843 O O . GLU A 1 120 ? 116.962 -6.345 36.465 1.00 24.40 ? 444 GLU A O 1 ATOM 844 C CB . GLU A 1 120 ? 117.467 -3.732 38.101 1.00 28.15 ? 444 GLU A CB 1 ATOM 845 C CG . GLU A 1 120 ? 117.026 -2.780 39.252 1.00 28.56 ? 444 GLU A CG 1 ATOM 846 C CD . GLU A 1 120 ? 117.982 -2.767 40.466 1.00 29.92 ? 444 GLU A CD 1 ATOM 847 O OE1 . GLU A 1 120 ? 119.154 -3.195 40.351 1.00 29.39 ? 444 GLU A OE1 1 ATOM 848 O OE2 . GLU A 1 120 ? 117.567 -2.317 41.562 1.00 31.34 ? 444 GLU A OE2 1 ATOM 849 N N . VAL A 1 121 ? 117.158 -4.744 34.894 1.00 26.05 ? 445 VAL A N 1 ATOM 850 C CA . VAL A 1 121 ? 117.619 -5.634 33.853 1.00 26.27 ? 445 VAL A CA 1 ATOM 851 C C . VAL A 1 121 ? 118.985 -5.166 33.391 1.00 27.90 ? 445 VAL A C 1 ATOM 852 O O . VAL A 1 121 ? 119.213 -3.967 33.225 1.00 31.15 ? 445 VAL A O 1 ATOM 853 C CB . VAL A 1 121 ? 116.691 -5.613 32.639 1.00 26.00 ? 445 VAL A CB 1 ATOM 854 C CG1 . VAL A 1 121 ? 117.149 -6.641 31.623 1.00 25.30 ? 445 VAL A CG1 1 ATOM 855 C CG2 . VAL A 1 121 ? 115.292 -5.906 33.064 1.00 26.82 ? 445 VAL A CG2 1 ATOM 856 N N . TYR A 1 122 ? 119.880 -6.119 33.167 1.00 26.78 ? 446 TYR A N 1 ATOM 857 C CA . TYR A 1 122 ? 121.260 -5.847 32.789 1.00 26.35 ? 446 TYR A CA 1 ATOM 858 C C . TYR A 1 122 ? 121.696 -7.011 31.943 1.00 24.46 ? 446 TYR A C 1 ATOM 859 O O . TYR A 1 122 ? 121.548 -8.153 32.368 1.00 25.80 ? 446 TYR A O 1 ATOM 860 C CB . TYR A 1 122 ? 122.194 -5.895 33.985 1.00 27.07 ? 446 TYR A CB 1 ATOM 861 C CG . TYR A 1 122 ? 121.865 -5.004 35.161 1.00 29.73 ? 446 TYR A CG 1 ATOM 862 C CD1 . TYR A 1 122 ? 121.204 -5.513 36.287 1.00 30.48 ? 446 TYR A CD1 1 ATOM 863 C CD2 . TYR A 1 122 ? 122.262 -3.669 35.182 1.00 29.02 ? 446 TYR A CD2 1 ATOM 864 C CE1 . TYR A 1 122 ? 120.924 -4.700 37.382 1.00 30.42 ? 446 TYR A CE1 1 ATOM 865 C CE2 . TYR A 1 122 ? 121.992 -2.867 36.277 1.00 29.67 ? 446 TYR A CE2 1 ATOM 866 C CZ . TYR A 1 122 ? 121.324 -3.385 37.372 1.00 29.57 ? 446 TYR A CZ 1 ATOM 867 O OH . TYR A 1 122 ? 121.049 -2.587 38.461 1.00 29.54 ? 446 TYR A OH 1 ATOM 868 N N . ALA A 1 123 ? 122.258 -6.711 30.782 1.00 22.54 ? 447 ALA A N 1 ATOM 869 C CA . ALA A 1 123 ? 122.590 -7.699 29.786 1.00 21.87 ? 447 ALA A CA 1 ATOM 870 C C . ALA A 1 123 ? 124.091 -7.621 29.506 1.00 20.55 ? 447 ALA A C 1 ATOM 871 O O . ALA A 1 123 ? 124.667 -6.559 29.570 1.00 18.96 ? 447 ALA A O 1 ATOM 872 C CB . ALA A 1 123 ? 121.780 -7.438 28.544 1.00 22.95 ? 447 ALA A CB 1 ATOM 873 N N . PHE A 1 124 ? 124.735 -8.749 29.227 1.00 20.56 ? 448 PHE A N 1 ATOM 874 C CA . PHE A 1 124 ? 126.184 -8.785 29.128 1.00 21.85 ? 448 PHE A CA 1 ATOM 875 C C . PHE A 1 124 ? 126.553 -9.807 28.074 1.00 22.96 ? 448 PHE A C 1 ATOM 876 O O . PHE A 1 124 ? 125.823 -10.780 27.840 1.00 20.77 ? 448 PHE A O 1 ATOM 877 C CB . PHE A 1 124 ? 126.850 -9.286 30.421 1.00 24.08 ? 448 PHE A CB 1 ATOM 878 C CG . PHE A 1 124 ? 126.557 -8.468 31.650 1.00 26.16 ? 448 PHE A CG 1 ATOM 879 C CD1 . PHE A 1 124 ? 125.795 -8.989 32.674 1.00 27.59 ? 448 PHE A CD1 1 ATOM 880 C CD2 . PHE A 1 124 ? 127.085 -7.196 31.804 1.00 28.94 ? 448 PHE A CD2 1 ATOM 881 C CE1 . PHE A 1 124 ? 125.527 -8.245 33.805 1.00 28.72 ? 448 PHE A CE1 1 ATOM 882 C CE2 . PHE A 1 124 ? 126.823 -6.446 32.939 1.00 29.24 ? 448 PHE A CE2 1 ATOM 883 C CZ . PHE A 1 124 ? 126.038 -6.979 33.942 1.00 28.81 ? 448 PHE A CZ 1 ATOM 884 N N . ALA A 1 125 ? 127.712 -9.616 27.460 1.00 22.87 ? 449 ALA A N 1 ATOM 885 C CA . ALA A 1 125 ? 128.197 -10.608 26.520 1.00 22.13 ? 449 ALA A CA 1 ATOM 886 C C . ALA A 1 125 ? 129.625 -10.975 26.867 1.00 21.84 ? 449 ALA A C 1 ATOM 887 O O . ALA A 1 125 ? 130.443 -10.116 27.118 1.00 21.53 ? 449 ALA A O 1 ATOM 888 C CB . ALA A 1 125 ? 128.123 -10.093 25.110 1.00 19.87 ? 449 ALA A CB 1 ATOM 889 N N . THR A 1 126 ? 129.926 -12.261 26.854 1.00 22.23 ? 450 THR A N 1 ATOM 890 C CA . THR A 1 126 ? 131.287 -12.702 27.117 1.00 24.02 ? 450 THR A CA 1 ATOM 891 C C . THR A 1 126 ? 132.249 -12.365 25.962 1.00 23.95 ? 450 THR A C 1 ATOM 892 O O . THR A 1 126 ? 131.842 -12.262 24.807 1.00 21.73 ? 450 THR A O 1 ATOM 893 C CB . THR A 1 126 ? 131.287 -14.219 27.364 1.00 24.20 ? 450 THR A CB 1 ATOM 894 O OG1 . THR A 1 126 ? 130.958 -14.874 26.140 1.00 23.12 ? 450 THR A OG1 1 ATOM 895 C CG2 . THR A 1 126 ? 130.255 -14.608 28.435 1.00 23.15 ? 450 THR A CG2 1 ATOM 896 N N . PRO A 1 127 ? 133.537 -12.178 26.269 1.00 25.82 ? 451 PRO A N 1 ATOM 897 C CA . PRO A 1 127 ? 134.547 -12.071 25.227 1.00 27.61 ? 451 PRO A CA 1 ATOM 898 C C . PRO A 1 127 ? 134.781 -13.428 24.582 1.00 29.68 ? 451 PRO A C 1 ATOM 899 O O . PRO A 1 127 ? 134.144 -14.407 24.971 1.00 30.81 ? 451 PRO A O 1 ATOM 900 C CB . PRO A 1 127 ? 135.817 -11.666 25.983 1.00 27.15 ? 451 PRO A CB 1 ATOM 901 C CG . PRO A 1 127 ? 135.432 -11.412 27.362 1.00 27.45 ? 451 PRO A CG 1 ATOM 902 C CD . PRO A 1 127 ? 134.144 -12.147 27.606 1.00 27.38 ? 451 PRO A CD 1 ATOM 903 N N . GLU A 1 128 ? 135.688 -13.484 23.618 1.00 32.48 ? 452 GLU A N 1 ATOM 904 C CA . GLU A 1 128 ? 135.928 -14.725 22.894 1.00 36.48 ? 452 GLU A CA 1 ATOM 905 C C . GLU A 1 128 ? 136.775 -15.649 23.751 1.00 37.20 ? 452 GLU A C 1 ATOM 906 O O . GLU A 1 128 ? 137.797 -15.231 24.286 1.00 37.28 ? 452 GLU A O 1 ATOM 907 C CB . GLU A 1 128 ? 136.635 -14.464 21.566 1.00 37.75 ? 452 GLU A CB 1 ATOM 908 C CG . GLU A 1 128 ? 136.954 -15.727 20.766 1.00 39.47 ? 452 GLU A CG 1 ATOM 909 C CD . GLU A 1 128 ? 137.710 -15.408 19.486 1.00 41.54 ? 452 GLU A CD 1 ATOM 910 O OE1 . GLU A 1 128 ? 137.212 -14.558 18.712 1.00 43.26 ? 452 GLU A OE1 1 ATOM 911 O OE2 . GLU A 1 128 ? 138.797 -15.994 19.257 1.00 42.65 ? 452 GLU A OE2 1 ATOM 912 N N . TRP A 1 129 ? 136.345 -16.900 23.881 1.00 38.57 ? 453 TRP A N 1 ATOM 913 C CA . TRP A 1 129 ? 137.157 -17.908 24.547 1.00 40.38 ? 453 TRP A CA 1 ATOM 914 C C . TRP A 1 129 ? 138.108 -18.482 23.522 1.00 42.69 ? 453 TRP A C 1 ATOM 915 O O . TRP A 1 129 ? 137.679 -18.840 22.416 1.00 42.83 ? 453 TRP A O 1 ATOM 916 C CB . TRP A 1 129 ? 136.311 -19.035 25.134 1.00 40.13 ? 453 TRP A CB 1 ATOM 917 C CG . TRP A 1 129 ? 137.077 -19.888 26.100 1.00 40.29 ? 453 TRP A CG 1 ATOM 918 C CD1 . TRP A 1 129 ? 137.599 -21.136 25.870 1.00 40.16 ? 453 TRP A CD1 1 ATOM 919 C CD2 . TRP A 1 129 ? 137.417 -19.555 27.453 1.00 40.25 ? 453 TRP A CD2 1 ATOM 920 N NE1 . TRP A 1 129 ? 138.239 -21.595 27.001 1.00 39.65 ? 453 TRP A NE1 1 ATOM 921 C CE2 . TRP A 1 129 ? 138.139 -20.646 27.984 1.00 40.33 ? 453 TRP A CE2 1 ATOM 922 C CE3 . TRP A 1 129 ? 137.177 -18.444 28.267 1.00 40.66 ? 453 TRP A CE3 1 ATOM 923 C CZ2 . TRP A 1 129 ? 138.624 -20.654 29.292 1.00 40.37 ? 453 TRP A CZ2 1 ATOM 924 C CZ3 . TRP A 1 129 ? 137.661 -18.455 29.564 1.00 41.11 ? 453 TRP A CZ3 1 ATOM 925 C CH2 . TRP A 1 129 ? 138.373 -19.555 30.065 1.00 40.53 ? 453 TRP A CH2 1 ATOM 926 N N . PRO A 1 130 ? 139.400 -18.565 23.890 1.00 45.16 ? 454 PRO A N 1 ATOM 927 C CA . PRO A 1 130 ? 140.417 -19.014 22.960 1.00 46.05 ? 454 PRO A CA 1 ATOM 928 C C . PRO A 1 130 ? 139.857 -20.168 22.142 1.00 47.01 ? 454 PRO A C 1 ATOM 929 O O . PRO A 1 130 ? 139.220 -21.067 22.692 1.00 46.34 ? 454 PRO A O 1 ATOM 930 C CB . PRO A 1 130 ? 141.539 -19.493 23.879 1.00 46.28 ? 454 PRO A CB 1 ATOM 931 C CG . PRO A 1 130 ? 141.396 -18.648 25.112 1.00 45.94 ? 454 PRO A CG 1 ATOM 932 C CD . PRO A 1 130 ? 139.950 -18.288 25.231 1.00 45.55 ? 454 PRO A CD 1 ATOM 933 N N . GLY A 1 131 ? 140.074 -20.121 20.835 1.00 48.41 ? 455 GLY A N 1 ATOM 934 C CA . GLY A 1 131 ? 139.704 -21.228 19.963 1.00 50.08 ? 455 GLY A CA 1 ATOM 935 C C . GLY A 1 131 ? 138.328 -21.047 19.341 1.00 51.71 ? 455 GLY A C 1 ATOM 936 O O . GLY A 1 131 ? 138.206 -20.657 18.166 1.00 53.31 ? 455 GLY A O 1 ATOM 937 N N . SER A 1 132 ? 137.289 -21.313 20.134 1.00 50.75 ? 456 SER A N 1 ATOM 938 C CA . SER A 1 132 ? 135.918 -21.358 19.625 1.00 49.92 ? 456 SER A CA 1 ATOM 939 C C . SER A 1 132 ? 135.270 -19.987 19.389 1.00 48.49 ? 456 SER A C 1 ATOM 940 O O . SER A 1 132 ? 134.563 -19.473 20.252 1.00 48.16 ? 456 SER A O 1 ATOM 941 C CB . SER A 1 132 ? 135.048 -22.143 20.602 1.00 50.00 ? 456 SER A CB 1 ATOM 942 O OG . SER A 1 132 ? 134.768 -21.347 21.735 1.00 48.84 ? 456 SER A OG 1 ATOM 943 N N . ARG A 1 133 ? 135.491 -19.403 18.214 1.00 46.59 ? 457 ARG A N 1 ATOM 944 C CA . ARG A 1 133 ? 135.070 -18.029 17.968 1.00 45.04 ? 457 ARG A CA 1 ATOM 945 C C . ARG A 1 133 ? 133.768 -17.974 17.198 1.00 42.21 ? 457 ARG A C 1 ATOM 946 O O . ARG A 1 133 ? 133.299 -16.902 16.822 1.00 38.41 ? 457 ARG A O 1 ATOM 947 C CB . ARG A 1 133 ? 136.140 -17.259 17.185 1.00 47.02 ? 457 ARG A CB 1 ATOM 948 C CG . ARG A 1 133 ? 136.267 -17.637 15.712 1.00 47.67 ? 457 ARG A CG 1 ATOM 949 C CD . ARG A 1 133 ? 136.604 -16.417 14.831 1.00 48.80 ? 457 ARG A CD 1 ATOM 950 N NE . ARG A 1 133 ? 136.528 -16.760 13.407 1.00 49.21 ? 457 ARG A NE 1 ATOM 951 C CZ . ARG A 1 133 ? 136.188 -15.925 12.426 1.00 47.64 ? 457 ARG A CZ 1 ATOM 952 N NH1 . ARG A 1 133 ? 135.882 -14.657 12.678 1.00 47.86 ? 457 ARG A NH1 1 ATOM 953 N NH2 . ARG A 1 133 ? 136.140 -16.380 11.183 1.00 45.97 ? 457 ARG A NH2 1 ATOM 954 N N . ASP A 1 134 ? 133.183 -19.137 16.953 1.00 40.92 ? 458 ASP A N 1 ATOM 955 C CA . ASP A 1 134 ? 131.912 -19.160 16.266 1.00 39.48 ? 458 ASP A CA 1 ATOM 956 C C . ASP A 1 134 ? 130.767 -19.094 17.253 1.00 37.52 ? 458 ASP A C 1 ATOM 957 O O . ASP A 1 134 ? 129.625 -19.337 16.889 1.00 36.62 ? 458 ASP A O 1 ATOM 958 C CB . ASP A 1 134 ? 131.820 -20.385 15.372 1.00 40.43 ? 458 ASP A CB 1 ATOM 959 C CG . ASP A 1 134 ? 132.558 -20.186 14.073 1.00 40.76 ? 458 ASP A CG 1 ATOM 960 O OD1 . ASP A 1 134 ? 133.346 -19.226 13.993 1.00 41.14 ? 458 ASP A OD1 1 ATOM 961 O OD2 . ASP A 1 134 ? 132.342 -20.976 13.135 1.00 42.63 ? 458 ASP A OD2 1 ATOM 962 N N . LYS A 1 135 ? 131.070 -18.745 18.498 1.00 36.13 ? 459 LYS A N 1 ATOM 963 C CA . LYS A 1 135 ? 130.030 -18.681 19.513 1.00 36.06 ? 459 LYS A CA 1 ATOM 964 C C . LYS A 1 135 ? 130.374 -17.708 20.622 1.00 32.04 ? 459 LYS A C 1 ATOM 965 O O . LYS A 1 135 ? 131.539 -17.460 20.897 1.00 32.29 ? 459 LYS A O 1 ATOM 966 C CB . LYS A 1 135 ? 129.746 -20.080 20.070 1.00 38.63 ? 459 LYS A CB 1 ATOM 967 C CG . LYS A 1 135 ? 130.913 -20.755 20.768 1.00 41.16 ? 459 LYS A CG 1 ATOM 968 C CD . LYS A 1 135 ? 130.515 -22.151 21.275 1.00 43.21 ? 459 LYS A CD 1 ATOM 969 C CE . LYS A 1 135 ? 131.601 -22.760 22.161 1.00 44.96 ? 459 LYS A CE 1 ATOM 970 N NZ . LYS A 1 135 ? 131.247 -24.115 22.695 1.00 46.72 ? 459 LYS A NZ 1 ATOM 971 N N . ARG A 1 136 ? 129.354 -17.111 21.223 1.00 27.89 ? 460 ARG A N 1 ATOM 972 C CA . ARG A 1 136 ? 129.529 -16.325 22.443 1.00 26.62 ? 460 ARG A CA 1 ATOM 973 C C . ARG A 1 136 ? 128.372 -16.634 23.357 1.00 24.61 ? 460 ARG A C 1 ATOM 974 O O . ARG A 1 136 ? 127.365 -17.171 22.930 1.00 23.04 ? 460 ARG A O 1 ATOM 975 C CB . ARG A 1 136 ? 129.521 -14.814 22.214 1.00 26.58 ? 460 ARG A CB 1 ATOM 976 C CG . ARG A 1 136 ? 130.608 -14.292 21.358 1.00 27.15 ? 460 ARG A CG 1 ATOM 977 C CD . ARG A 1 136 ? 131.983 -14.289 22.045 1.00 28.45 ? 460 ARG A CD 1 ATOM 978 N NE . ARG A 1 136 ? 132.960 -13.769 21.087 1.00 28.34 ? 460 ARG A NE 1 ATOM 979 C CZ . ARG A 1 136 ? 133.293 -12.484 20.999 1.00 30.48 ? 460 ARG A CZ 1 ATOM 980 N NH1 . ARG A 1 136 ? 132.781 -11.591 21.839 1.00 32.84 ? 460 ARG A NH1 1 ATOM 981 N NH2 . ARG A 1 136 ? 134.167 -12.079 20.091 1.00 31.09 ? 460 ARG A NH2 1 ATOM 982 N N . THR A 1 137 ? 128.521 -16.274 24.621 1.00 24.65 ? 461 THR A N 1 ATOM 983 C CA . THR A 1 137 ? 127.465 -16.488 25.569 1.00 23.55 ? 461 THR A CA 1 ATOM 984 C C . THR A 1 137 ? 127.000 -15.114 26.031 1.00 23.42 ? 461 THR A C 1 ATOM 985 O O . THR A 1 137 ? 127.809 -14.267 26.423 1.00 25.47 ? 461 THR A O 1 ATOM 986 C CB . THR A 1 137 ? 127.961 -17.313 26.759 1.00 25.33 ? 461 THR A CB 1 ATOM 987 O OG1 . THR A 1 137 ? 128.453 -18.585 26.322 1.00 26.00 ? 461 THR A OG1 1 ATOM 988 C CG2 . THR A 1 137 ? 126.851 -17.552 27.742 1.00 25.83 ? 461 THR A CG2 1 ATOM 989 N N . LEU A 1 138 ? 125.686 -14.917 25.976 1.00 22.29 ? 462 LEU A N 1 ATOM 990 C CA . LEU A 1 138 ? 125.019 -13.730 26.448 1.00 20.24 ? 462 LEU A CA 1 ATOM 991 C C . LEU A 1 138 ? 124.352 -14.028 27.774 1.00 21.89 ? 462 LEU A C 1 ATOM 992 O O . LEU A 1 138 ? 123.768 -15.080 27.970 1.00 25.30 ? 462 LEU A O 1 ATOM 993 C CB . LEU A 1 138 ? 123.947 -13.315 25.433 1.00 20.38 ? 462 LEU A CB 1 ATOM 994 C CG . LEU A 1 138 ? 124.406 -13.047 23.989 1.00 19.86 ? 462 LEU A CG 1 ATOM 995 C CD1 . LEU A 1 138 ? 123.275 -12.438 23.147 1.00 19.01 ? 462 LEU A CD1 1 ATOM 996 C CD2 . LEU A 1 138 ? 125.619 -12.167 23.976 1.00 16.94 ? 462 LEU A CD2 1 ATOM 997 N N . ALA A 1 139 ? 124.420 -13.085 28.696 1.00 24.14 ? 463 ALA A N 1 ATOM 998 C CA . ALA A 1 139 ? 123.806 -13.244 30.001 1.00 24.55 ? 463 ALA A CA 1 ATOM 999 C C . ALA A 1 139 ? 122.982 -12.021 30.374 1.00 24.83 ? 463 ALA A C 1 ATOM 1000 O O . ALA A 1 139 ? 123.222 -10.897 29.937 1.00 26.37 ? 463 ALA A O 1 ATOM 1001 C CB . ALA A 1 139 ? 124.879 -13.461 31.044 1.00 23.35 ? 463 ALA A CB 1 ATOM 1002 N N . CYS A 1 140 ? 122.015 -12.254 31.235 1.00 24.45 ? 464 CYS A N 1 ATOM 1003 C CA . CYS A 1 140 ? 121.096 -11.214 31.625 1.00 26.19 ? 464 CYS A CA 1 ATOM 1004 C C . CYS A 1 140 ? 120.829 -11.385 33.112 1.00 24.49 ? 464 CYS A C 1 ATOM 1005 O O . CYS A 1 140 ? 120.503 -12.489 33.570 1.00 24.46 ? 464 CYS A O 1 ATOM 1006 C CB . CYS A 1 140 ? 119.781 -11.381 30.863 1.00 27.65 ? 464 CYS A CB 1 ATOM 1007 S SG . CYS A 1 140 ? 118.733 -9.973 31.048 1.00 30.65 ? 464 CYS A SG 1 ATOM 1008 N N . LEU A 1 141 ? 120.962 -10.300 33.855 1.00 20.57 ? 465 LEU A N 1 ATOM 1009 C CA . LEU A 1 141 ? 120.613 -10.310 35.271 1.00 19.04 ? 465 LEU A CA 1 ATOM 1010 C C . LEU A 1 141 ? 119.393 -9.450 35.480 1.00 18.38 ? 465 LEU A C 1 ATOM 1011 O O . LEU A 1 141 ? 119.403 -8.276 35.117 1.00 17.21 ? 465 LEU A O 1 ATOM 1012 C CB . LEU A 1 141 ? 121.747 -9.728 36.083 1.00 17.31 ? 465 LEU A CB 1 ATOM 1013 C CG . LEU A 1 141 ? 121.566 -9.512 37.575 1.00 18.03 ? 465 LEU A CG 1 ATOM 1014 C CD1 . LEU A 1 141 ? 120.984 -10.722 38.250 1.00 18.29 ? 465 LEU A CD1 1 ATOM 1015 C CD2 . LEU A 1 141 ? 122.957 -9.145 38.156 1.00 16.76 ? 465 LEU A CD2 1 ATOM 1016 N N . ILE A 1 142 ? 118.367 -10.047 36.073 1.00 19.77 ? 466 ILE A N 1 ATOM 1017 C CA . ILE A 1 142 ? 117.119 -9.371 36.434 1.00 20.00 ? 466 ILE A CA 1 ATOM 1018 C C . ILE A 1 142 ? 116.964 -9.467 37.936 1.00 19.91 ? 466 ILE A C 1 ATOM 1019 O O . ILE A 1 142 ? 116.872 -10.578 38.476 1.00 20.60 ? 466 ILE A O 1 ATOM 1020 C CB . ILE A 1 142 ? 115.914 -10.104 35.813 1.00 20.16 ? 466 ILE A CB 1 ATOM 1021 C CG1 . ILE A 1 142 ? 116.157 -10.315 34.328 1.00 22.42 ? 466 ILE A CG1 1 ATOM 1022 C CG2 . ILE A 1 142 ? 114.621 -9.318 35.982 1.00 19.61 ? 466 ILE A CG2 1 ATOM 1023 C CD1 . ILE A 1 142 ? 116.365 -8.992 33.661 1.00 26.27 ? 466 ILE A CD1 1 ATOM 1024 N N . GLN A 1 143 ? 116.911 -8.327 38.610 1.00 20.50 ? 467 GLN A N 1 ATOM 1025 C CA . GLN A 1 143 ? 117.004 -8.333 40.069 1.00 22.96 ? 467 GLN A CA 1 ATOM 1026 C C . GLN A 1 143 ? 116.156 -7.293 40.767 1.00 23.93 ? 467 GLN A C 1 ATOM 1027 O O . GLN A 1 143 ? 115.617 -6.387 40.140 1.00 24.80 ? 467 GLN A O 1 ATOM 1028 C CB . GLN A 1 143 ? 118.456 -8.171 40.514 1.00 24.12 ? 467 GLN A CB 1 ATOM 1029 C CG . GLN A 1 143 ? 119.092 -6.851 40.118 1.00 25.22 ? 467 GLN A CG 1 ATOM 1030 C CD . GLN A 1 143 ? 120.483 -6.721 40.720 1.00 25.71 ? 467 GLN A CD 1 ATOM 1031 O OE1 . GLN A 1 143 ? 121.063 -7.721 41.122 1.00 27.03 ? 467 GLN A OE1 1 ATOM 1032 N NE2 . GLN A 1 143 ? 121.017 -5.504 40.788 1.00 23.90 ? 467 GLN A NE2 1 ATOM 1033 N N . ASN A 1 144 ? 116.045 -7.442 42.079 1.00 25.30 ? 468 ASN A N 1 ATOM 1034 C CA . ASN A 1 144 ? 115.314 -6.498 42.910 1.00 27.53 ? 468 ASN A CA 1 ATOM 1035 C C . ASN A 1 144 ? 113.849 -6.332 42.477 1.00 29.87 ? 468 ASN A C 1 ATOM 1036 O O . ASN A 1 144 ? 113.302 -5.222 42.488 1.00 32.01 ? 468 ASN A O 1 ATOM 1037 C CB . ASN A 1 144 ? 116.057 -5.161 42.953 1.00 27.37 ? 468 ASN A CB 1 ATOM 1038 C CG . ASN A 1 144 ? 117.367 -5.249 43.744 1.00 28.50 ? 468 ASN A CG 1 ATOM 1039 O OD1 . ASN A 1 144 ? 117.535 -6.136 44.579 1.00 29.07 ? 468 ASN A OD1 1 ATOM 1040 N ND2 . ASN A 1 144 ? 118.291 -4.330 43.486 1.00 27.71 ? 468 ASN A ND2 1 ATOM 1041 N N . PHE A 1 145 ? 113.195 -7.431 42.106 1.00 29.28 ? 469 PHE A N 1 ATOM 1042 C CA . PHE A 1 145 ? 111.771 -7.345 41.776 1.00 28.58 ? 469 PHE A CA 1 ATOM 1043 C C . PHE A 1 145 ? 110.919 -8.116 42.763 1.00 27.85 ? 469 PHE A C 1 ATOM 1044 O O . PHE A 1 145 ? 111.411 -9.034 43.413 1.00 27.45 ? 469 PHE A O 1 ATOM 1045 C CB . PHE A 1 145 ? 111.502 -7.816 40.354 1.00 27.99 ? 469 PHE A CB 1 ATOM 1046 C CG . PHE A 1 145 ? 111.972 -9.219 40.067 1.00 27.60 ? 469 PHE A CG 1 ATOM 1047 C CD1 . PHE A 1 145 ? 111.165 -10.293 40.346 1.00 25.98 ? 469 PHE A CD1 1 ATOM 1048 C CD2 . PHE A 1 145 ? 113.214 -9.449 39.495 1.00 27.88 ? 469 PHE A CD2 1 ATOM 1049 C CE1 . PHE A 1 145 ? 111.571 -11.567 40.079 1.00 26.23 ? 469 PHE A CE1 1 ATOM 1050 C CE2 . PHE A 1 145 ? 113.638 -10.719 39.228 1.00 27.22 ? 469 PHE A CE2 1 ATOM 1051 C CZ . PHE A 1 145 ? 112.812 -11.785 39.512 1.00 26.87 ? 469 PHE A CZ 1 ATOM 1052 N N . MET A 1 146 ? 109.659 -7.713 42.896 1.00 29.31 ? 470 MET A N 1 ATOM 1053 C CA . MET A 1 146 ? 108.673 -8.490 43.649 1.00 30.37 ? 470 MET A CA 1 ATOM 1054 C C . MET A 1 146 ? 107.241 -8.222 43.180 1.00 28.37 ? 470 MET A C 1 ATOM 1055 O O . MET A 1 146 ? 106.936 -7.144 42.680 1.00 28.72 ? 470 MET A O 1 ATOM 1056 C CB . MET A 1 146 ? 108.809 -8.246 45.153 1.00 32.89 ? 470 MET A CB 1 ATOM 1057 C CG . MET A 1 146 ? 108.828 -6.806 45.526 1.00 35.04 ? 470 MET A CG 1 ATOM 1058 S SD . MET A 1 146 ? 109.013 -6.553 47.307 1.00 38.90 ? 470 MET A SD 1 ATOM 1059 C CE . MET A 1 146 ? 110.565 -7.355 47.662 1.00 38.63 ? 470 MET A CE 1 ATOM 1060 N N . PRO A 1 147 ? 106.370 -9.228 43.295 1.00 26.57 ? 471 PRO A N 1 ATOM 1061 C CA . PRO A 1 147 ? 106.681 -10.593 43.719 1.00 27.33 ? 471 PRO A CA 1 ATOM 1062 C C . PRO A 1 147 ? 107.557 -11.367 42.712 1.00 25.96 ? 471 PRO A C 1 ATOM 1063 O O . PRO A 1 147 ? 108.009 -10.815 41.711 1.00 26.08 ? 471 PRO A O 1 ATOM 1064 C CB . PRO A 1 147 ? 105.308 -11.256 43.848 1.00 27.39 ? 471 PRO A CB 1 ATOM 1065 C CG . PRO A 1 147 ? 104.328 -10.290 43.310 1.00 27.46 ? 471 PRO A CG 1 ATOM 1066 C CD . PRO A 1 147 ? 105.026 -9.127 42.722 1.00 27.04 ? 471 PRO A CD 1 ATOM 1067 N N . GLU A 1 148 ? 107.792 -12.637 42.993 1.00 25.43 ? 472 GLU A N 1 ATOM 1068 C CA . GLU A 1 148 ? 108.753 -13.419 42.247 1.00 27.95 ? 472 GLU A CA 1 ATOM 1069 C C . GLU A 1 148 ? 108.354 -13.752 40.805 1.00 27.25 ? 472 GLU A C 1 ATOM 1070 O O . GLU A 1 148 ? 109.180 -14.226 40.023 1.00 25.72 ? 472 GLU A O 1 ATOM 1071 C CB . GLU A 1 148 ? 109.055 -14.700 43.002 1.00 29.58 ? 472 GLU A CB 1 ATOM 1072 C CG . GLU A 1 148 ? 107.847 -15.563 43.275 1.00 32.50 ? 472 GLU A CG 1 ATOM 1073 C CD . GLU A 1 148 ? 108.162 -16.648 44.296 1.00 35.19 ? 472 GLU A CD 1 ATOM 1074 O OE1 . GLU A 1 148 ? 107.355 -16.805 45.239 1.00 36.01 ? 472 GLU A OE1 1 ATOM 1075 O OE2 . GLU A 1 148 ? 109.215 -17.328 44.154 1.00 36.94 ? 472 GLU A OE2 1 ATOM 1076 N N . ASP A 1 149 ? 107.101 -13.504 40.452 1.00 27.45 ? 473 ASP A N 1 ATOM 1077 C CA . ASP A 1 149 ? 106.596 -13.952 39.173 1.00 28.50 ? 473 ASP A CA 1 ATOM 1078 C C . ASP A 1 149 ? 107.189 -13.094 38.066 1.00 29.43 ? 473 ASP A C 1 ATOM 1079 O O . ASP A 1 149 ? 107.056 -11.862 38.074 1.00 28.47 ? 473 ASP A O 1 ATOM 1080 C CB . ASP A 1 149 ? 105.073 -13.884 39.153 1.00 30.92 ? 473 ASP A CB 1 ATOM 1081 C CG . ASP A 1 149 ? 104.419 -15.136 39.740 1.00 33.09 ? 473 ASP A CG 1 ATOM 1082 O OD1 . ASP A 1 149 ? 105.133 -16.124 40.051 1.00 33.34 ? 473 ASP A OD1 1 ATOM 1083 O OD2 . ASP A 1 149 ? 103.174 -15.137 39.875 1.00 33.74 ? 473 ASP A OD2 1 ATOM 1084 N N . ILE A 1 150 ? 107.850 -13.751 37.113 1.00 28.04 ? 474 ILE A N 1 ATOM 1085 C CA . ILE A 1 150 ? 108.500 -13.026 36.034 1.00 27.07 ? 474 ILE A CA 1 ATOM 1086 C C . ILE A 1 150 ? 108.654 -13.880 34.773 1.00 26.18 ? 474 ILE A C 1 ATOM 1087 O O . ILE A 1 150 ? 108.909 -15.070 34.839 1.00 23.37 ? 474 ILE A O 1 ATOM 1088 C CB . ILE A 1 150 ? 109.878 -12.518 36.488 1.00 27.30 ? 474 ILE A CB 1 ATOM 1089 C CG1 . ILE A 1 150 ? 110.331 -11.388 35.573 1.00 27.52 ? 474 ILE A CG1 1 ATOM 1090 C CG2 . ILE A 1 150 ? 110.870 -13.659 36.495 1.00 26.52 ? 474 ILE A CG2 1 ATOM 1091 C CD1 . ILE A 1 150 ? 111.241 -10.410 36.229 1.00 27.59 ? 474 ILE A CD1 1 ATOM 1092 N N . SER A 1 151 ? 108.483 -13.254 33.617 1.00 25.33 ? 475 SER A N 1 ATOM 1093 C CA . SER A 1 151 ? 108.758 -13.902 32.352 1.00 23.74 ? 475 SER A CA 1 ATOM 1094 C C . SER A 1 151 ? 109.980 -13.274 31.748 1.00 23.43 ? 475 SER A C 1 ATOM 1095 O O . SER A 1 151 ? 110.057 -12.052 31.669 1.00 23.06 ? 475 SER A O 1 ATOM 1096 C CB . SER A 1 151 ? 107.584 -13.754 31.398 1.00 22.28 ? 475 SER A CB 1 ATOM 1097 O OG . SER A 1 151 ? 106.526 -14.560 31.843 1.00 23.42 ? 475 SER A OG 1 ATOM 1098 N N . VAL A 1 152 ? 110.923 -14.109 31.311 1.00 23.84 ? 476 VAL A N 1 ATOM 1099 C CA . VAL A 1 152 ? 112.136 -13.618 30.674 1.00 23.13 ? 476 VAL A CA 1 ATOM 1100 C C . VAL A 1 152 ? 112.224 -14.165 29.282 1.00 24.39 ? 476 VAL A C 1 ATOM 1101 O O . VAL A 1 152 ? 112.027 -15.353 29.095 1.00 25.19 ? 476 VAL A O 1 ATOM 1102 C CB . VAL A 1 152 ? 113.409 -14.047 31.413 1.00 22.98 ? 476 VAL A CB 1 ATOM 1103 C CG1 . VAL A 1 152 ? 114.642 -13.490 30.677 1.00 20.63 ? 476 VAL A CG1 1 ATOM 1104 C CG2 . VAL A 1 152 ? 113.372 -13.582 32.870 1.00 20.32 ? 476 VAL A CG2 1 ATOM 1105 N N . GLN A 1 153 ? 112.529 -13.317 28.298 1.00 26.69 ? 477 GLN A N 1 ATOM 1106 C CA . GLN A 1 153 ? 112.625 -13.798 26.916 1.00 28.14 ? 477 GLN A CA 1 ATOM 1107 C C . GLN A 1 153 ? 113.724 -13.119 26.151 1.00 27.34 ? 477 GLN A C 1 ATOM 1108 O O . GLN A 1 153 ? 114.151 -12.051 26.555 1.00 26.16 ? 477 GLN A O 1 ATOM 1109 C CB . GLN A 1 153 ? 111.302 -13.632 26.188 1.00 30.93 ? 477 GLN A CB 1 ATOM 1110 C CG . GLN A 1 153 ? 110.667 -12.340 26.484 1.00 34.68 ? 477 GLN A CG 1 ATOM 1111 C CD . GLN A 1 153 ? 109.273 -12.275 25.953 1.00 36.59 ? 477 GLN A CD 1 ATOM 1112 O OE1 . GLN A 1 153 ? 108.812 -11.217 25.512 1.00 38.53 ? 477 GLN A OE1 1 ATOM 1113 N NE2 . GLN A 1 153 ? 108.590 -13.407 25.977 1.00 37.79 ? 477 GLN A NE2 1 ATOM 1114 N N . TRP A 1 154 ? 114.226 -13.743 25.079 1.00 26.12 ? 478 TRP A N 1 ATOM 1115 C CA . TRP A 1 154 ? 115.299 -13.102 24.318 1.00 23.11 ? 478 TRP A CA 1 ATOM 1116 C C . TRP A 1 154 ? 114.841 -12.767 22.930 1.00 23.33 ? 478 TRP A C 1 ATOM 1117 O O . TRP A 1 154 ? 114.098 -13.508 22.316 1.00 24.15 ? 478 TRP A O 1 ATOM 1118 C CB . TRP A 1 154 ? 116.535 -13.989 24.206 1.00 22.69 ? 478 TRP A CB 1 ATOM 1119 C CG . TRP A 1 154 ? 117.290 -14.168 25.476 1.00 22.07 ? 478 TRP A CG 1 ATOM 1120 C CD1 . TRP A 1 154 ? 117.042 -15.091 26.440 1.00 22.30 ? 478 TRP A CD1 1 ATOM 1121 C CD2 . TRP A 1 154 ? 118.423 -13.415 25.921 1.00 22.42 ? 478 TRP A CD2 1 ATOM 1122 N NE1 . TRP A 1 154 ? 117.935 -14.942 27.475 1.00 22.86 ? 478 TRP A NE1 1 ATOM 1123 C CE2 . TRP A 1 154 ? 118.804 -13.932 27.171 1.00 22.72 ? 478 TRP A CE2 1 ATOM 1124 C CE3 . TRP A 1 154 ? 119.147 -12.345 25.385 1.00 23.71 ? 478 TRP A CE3 1 ATOM 1125 C CZ2 . TRP A 1 154 ? 119.887 -13.431 27.894 1.00 23.08 ? 478 TRP A CZ2 1 ATOM 1126 C CZ3 . TRP A 1 154 ? 120.208 -11.828 26.113 1.00 22.53 ? 478 TRP A CZ3 1 ATOM 1127 C CH2 . TRP A 1 154 ? 120.569 -12.374 27.346 1.00 23.22 ? 478 TRP A CH2 1 ATOM 1128 N N . LEU A 1 155 ? 115.329 -11.664 22.397 1.00 24.66 ? 479 LEU A N 1 ATOM 1129 C CA . LEU A 1 155 ? 114.900 -11.234 21.079 1.00 26.17 ? 479 LEU A CA 1 ATOM 1130 C C . LEU A 1 155 ? 116.048 -11.032 20.086 1.00 26.76 ? 479 LEU A C 1 ATOM 1131 O O . LEU A 1 155 ? 117.158 -10.627 20.432 1.00 27.10 ? 479 LEU A O 1 ATOM 1132 C CB . LEU A 1 155 ? 114.098 -9.939 21.210 1.00 26.94 ? 479 LEU A CB 1 ATOM 1133 C CG . LEU A 1 155 ? 112.674 -10.120 21.723 1.00 28.45 ? 479 LEU A CG 1 ATOM 1134 C CD1 . LEU A 1 155 ? 112.604 -10.100 23.206 1.00 27.47 ? 479 LEU A CD1 1 ATOM 1135 C CD2 . LEU A 1 155 ? 111.767 -9.031 21.138 1.00 30.16 ? 479 LEU A CD2 1 ATOM 1136 N N . HIS A 1 156 ? 115.772 -11.303 18.823 1.00 26.67 ? 480 HIS A N 1 ATOM 1137 C CA . HIS A 1 156 ? 116.739 -11.004 17.793 1.00 26.30 ? 480 HIS A CA 1 ATOM 1138 C C . HIS A 1 156 ? 115.945 -10.528 16.587 1.00 27.59 ? 480 HIS A C 1 ATOM 1139 O O . HIS A 1 156 ? 114.942 -11.142 16.227 1.00 25.24 ? 480 HIS A O 1 ATOM 1140 C CB . HIS A 1 156 ? 117.552 -12.256 17.498 1.00 26.12 ? 480 HIS A CB 1 ATOM 1141 C CG . HIS A 1 156 ? 118.778 -12.000 16.685 1.00 25.71 ? 480 HIS A CG 1 ATOM 1142 N ND1 . HIS A 1 156 ? 119.135 -12.802 15.627 1.00 26.56 ? 480 HIS A ND1 1 ATOM 1143 C CD2 . HIS A 1 156 ? 119.721 -11.033 16.764 1.00 24.50 ? 480 HIS A CD2 1 ATOM 1144 C CE1 . HIS A 1 156 ? 120.255 -12.345 15.095 1.00 25.19 ? 480 HIS A CE1 1 ATOM 1145 N NE2 . HIS A 1 156 ? 120.634 -11.276 15.771 1.00 23.91 ? 480 HIS A NE2 1 ATOM 1146 N N . ASN A 1 157 ? 116.384 -9.412 16.005 1.00 30.73 ? 481 ASN A N 1 ATOM 1147 C CA . ASN A 1 157 ? 115.680 -8.760 14.913 1.00 32.44 ? 481 ASN A CA 1 ATOM 1148 C C . ASN A 1 157 ? 114.253 -8.478 15.346 1.00 36.53 ? 481 ASN A C 1 ATOM 1149 O O . ASN A 1 157 ? 113.291 -8.780 14.630 1.00 37.89 ? 481 ASN A O 1 ATOM 1150 C CB . ASN A 1 157 ? 115.677 -9.646 13.667 1.00 32.15 ? 481 ASN A CB 1 ATOM 1151 C CG . ASN A 1 157 ? 117.061 -9.999 13.208 1.00 32.51 ? 481 ASN A CG 1 ATOM 1152 O OD1 . ASN A 1 157 ? 117.906 -9.124 13.042 1.00 33.76 ? 481 ASN A OD1 1 ATOM 1153 N ND2 . ASN A 1 157 ? 117.308 -11.285 12.996 1.00 32.02 ? 481 ASN A ND2 1 ATOM 1154 N N . GLU A 1 158 ? 114.123 -7.908 16.538 1.00 40.13 ? 482 GLU A N 1 ATOM 1155 C CA . GLU A 1 158 ? 112.821 -7.542 17.108 1.00 43.20 ? 482 GLU A CA 1 ATOM 1156 C C . GLU A 1 158 ? 111.902 -8.758 17.152 1.00 43.54 ? 482 GLU A C 1 ATOM 1157 O O . GLU A 1 158 ? 110.678 -8.607 17.263 1.00 44.82 ? 482 GLU A O 1 ATOM 1158 C CB . GLU A 1 158 ? 112.140 -6.405 16.325 1.00 45.46 ? 482 GLU A CB 1 ATOM 1159 C CG . GLU A 1 158 ? 113.069 -5.306 15.774 1.00 47.88 ? 482 GLU A CG 1 ATOM 1160 C CD . GLU A 1 158 ? 114.328 -5.097 16.615 1.00 50.06 ? 482 GLU A CD 1 ATOM 1161 O OE1 . GLU A 1 158 ? 114.214 -5.077 17.870 1.00 51.92 ? 482 GLU A OE1 1 ATOM 1162 O OE2 . GLU A 1 158 ? 115.430 -4.966 16.012 1.00 50.75 ? 482 GLU A OE2 1 ATOM 1163 N N . VAL A 1 159 ? 112.495 -9.949 17.060 1.00 42.06 ? 483 VAL A N 1 ATOM 1164 C CA . VAL A 1 159 ? 111.725 -11.186 17.038 1.00 40.98 ? 483 VAL A CA 1 ATOM 1165 C C . VAL A 1 159 ? 112.218 -12.130 18.117 1.00 39.57 ? 483 VAL A C 1 ATOM 1166 O O . VAL A 1 159 ? 113.418 -12.232 18.370 1.00 38.90 ? 483 VAL A O 1 ATOM 1167 C CB . VAL A 1 159 ? 111.822 -11.875 15.675 1.00 41.01 ? 483 VAL A CB 1 ATOM 1168 C CG1 . VAL A 1 159 ? 111.300 -13.307 15.751 1.00 40.43 ? 483 VAL A CG1 1 ATOM 1169 C CG2 . VAL A 1 159 ? 111.059 -11.055 14.665 1.00 41.17 ? 483 VAL A CG2 1 ATOM 1170 N N . GLN A 1 160 ? 111.266 -12.813 18.739 1.00 37.64 ? 484 GLN A N 1 ATOM 1171 C CA . GLN A 1 160 ? 111.511 -13.584 19.938 1.00 36.71 ? 484 GLN A CA 1 ATOM 1172 C C . GLN A 1 160 ? 112.071 -14.936 19.519 1.00 35.48 ? 484 GLN A C 1 ATOM 1173 O O . GLN A 1 160 ? 111.533 -15.572 18.607 1.00 33.37 ? 484 GLN A O 1 ATOM 1174 C CB . GLN A 1 160 ? 110.197 -13.724 20.724 1.00 37.76 ? 484 GLN A CB 1 ATOM 1175 C CG . GLN A 1 160 ? 110.290 -14.608 21.954 1.00 39.09 ? 484 GLN A CG 1 ATOM 1176 C CD . GLN A 1 160 ? 109.054 -14.548 22.848 1.00 40.67 ? 484 GLN A CD 1 ATOM 1177 O OE1 . GLN A 1 160 ? 108.785 -15.482 23.616 1.00 40.18 ? 484 GLN A OE1 1 ATOM 1178 N NE2 . GLN A 1 160 ? 108.303 -13.449 22.758 1.00 41.56 ? 484 GLN A NE2 1 ATOM 1179 N N . LEU A 1 161 ? 113.157 -15.367 20.165 1.00 34.63 ? 485 LEU A N 1 ATOM 1180 C CA . LEU A 1 161 ? 113.735 -16.690 19.903 1.00 32.90 ? 485 LEU A CA 1 ATOM 1181 C C . LEU A 1 161 ? 113.013 -17.787 20.680 1.00 33.01 ? 485 LEU A C 1 ATOM 1182 O O . LEU A 1 161 ? 112.338 -17.524 21.672 1.00 31.78 ? 485 LEU A O 1 ATOM 1183 C CB . LEU A 1 161 ? 115.217 -16.711 20.265 1.00 32.75 ? 485 LEU A CB 1 ATOM 1184 C CG . LEU A 1 161 ? 116.133 -15.728 19.523 1.00 32.81 ? 485 LEU A CG 1 ATOM 1185 C CD1 . LEU A 1 161 ? 117.345 -15.411 20.351 1.00 31.60 ? 485 LEU A CD1 1 ATOM 1186 C CD2 . LEU A 1 161 ? 116.543 -16.250 18.159 1.00 31.00 ? 485 LEU A CD2 1 ATOM 1187 N N . PRO A 1 162 ? 113.153 -19.035 20.225 1.00 33.67 ? 486 PRO A N 1 ATOM 1188 C CA . PRO A 1 162 ? 112.495 -20.145 20.894 1.00 34.39 ? 486 PRO A CA 1 ATOM 1189 C C . PRO A 1 162 ? 112.975 -20.301 22.337 1.00 36.21 ? 486 PRO A C 1 ATOM 1190 O O . PRO A 1 162 ? 114.183 -20.352 22.565 1.00 37.02 ? 486 PRO A O 1 ATOM 1191 C CB . PRO A 1 162 ? 112.930 -21.373 20.074 1.00 33.78 ? 486 PRO A CB 1 ATOM 1192 C CG . PRO A 1 162 ? 113.363 -20.846 18.741 1.00 33.41 ? 486 PRO A CG 1 ATOM 1193 C CD . PRO A 1 162 ? 113.882 -19.455 19.013 1.00 34.37 ? 486 PRO A CD 1 ATOM 1194 N N . ASP A 1 163 ? 112.037 -20.412 23.280 1.00 36.18 ? 487 ASP A N 1 ATOM 1195 C CA . ASP A 1 163 ? 112.343 -20.698 24.681 1.00 37.33 ? 487 ASP A CA 1 ATOM 1196 C C . ASP A 1 163 ? 113.534 -21.647 24.929 1.00 35.59 ? 487 ASP A C 1 ATOM 1197 O O . ASP A 1 163 ? 114.377 -21.375 25.779 1.00 35.76 ? 487 ASP A O 1 ATOM 1198 C CB . ASP A 1 163 ? 111.086 -21.236 25.399 1.00 39.90 ? 487 ASP A CB 1 ATOM 1199 C CG . ASP A 1 163 ? 110.049 -20.143 25.689 1.00 41.78 ? 487 ASP A CG 1 ATOM 1200 O OD1 . ASP A 1 163 ? 110.401 -18.942 25.747 1.00 43.80 ? 487 ASP A OD1 1 ATOM 1201 O OD2 . ASP A 1 163 ? 108.862 -20.484 25.866 1.00 44.24 ? 487 ASP A OD2 1 ATOM 1202 N N . ALA A 1 164 ? 113.626 -22.758 24.213 1.00 33.75 ? 488 ALA A N 1 ATOM 1203 C CA . ALA A 1 164 ? 114.636 -23.773 24.542 1.00 33.28 ? 488 ALA A CA 1 ATOM 1204 C C . ALA A 1 164 ? 116.065 -23.279 24.236 1.00 31.91 ? 488 ALA A C 1 ATOM 1205 O O . ALA A 1 164 ? 117.069 -23.904 24.600 1.00 30.13 ? 488 ALA A O 1 ATOM 1206 C CB . ALA A 1 164 ? 114.329 -25.095 23.805 1.00 31.35 ? 488 ALA A CB 1 ATOM 1207 N N . ARG A 1 165 ? 116.148 -22.146 23.550 1.00 31.48 ? 489 ARG A N 1 ATOM 1208 C CA . ARG A 1 165 ? 117.428 -21.551 23.238 1.00 31.45 ? 489 ARG A CA 1 ATOM 1209 C C . ARG A 1 165 ? 118.113 -20.952 24.467 1.00 31.05 ? 489 ARG A C 1 ATOM 1210 O O . ARG A 1 165 ? 119.344 -20.893 24.511 1.00 29.50 ? 489 ARG A O 1 ATOM 1211 C CB . ARG A 1 165 ? 117.236 -20.460 22.198 1.00 33.33 ? 489 ARG A CB 1 ATOM 1212 C CG . ARG A 1 165 ? 117.514 -20.958 20.798 1.00 33.86 ? 489 ARG A CG 1 ATOM 1213 C CD . ARG A 1 165 ? 119.005 -21.107 20.672 1.00 35.12 ? 489 ARG A CD 1 ATOM 1214 N NE . ARG A 1 165 ? 119.415 -20.855 19.310 1.00 36.86 ? 489 ARG A NE 1 ATOM 1215 C CZ . ARG A 1 165 ? 120.003 -19.750 18.868 1.00 37.66 ? 489 ARG A CZ 1 ATOM 1216 N NH1 . ARG A 1 165 ? 120.316 -18.771 19.679 1.00 35.74 ? 489 ARG A NH1 1 ATOM 1217 N NH2 . ARG A 1 165 ? 120.324 -19.657 17.583 1.00 41.05 ? 489 ARG A NH2 1 ATOM 1218 N N . HIS A 1 166 ? 117.325 -20.516 25.454 1.00 29.05 ? 490 HIS A N 1 ATOM 1219 C CA . HIS A 1 166 ? 117.893 -19.950 26.669 1.00 29.12 ? 490 HIS A CA 1 ATOM 1220 C C . HIS A 1 166 ? 117.640 -20.832 27.881 1.00 27.39 ? 490 HIS A C 1 ATOM 1221 O O . HIS A 1 166 ? 116.857 -21.752 27.833 1.00 26.31 ? 490 HIS A O 1 ATOM 1222 C CB . HIS A 1 166 ? 117.430 -18.495 26.905 1.00 29.02 ? 490 HIS A CB 1 ATOM 1223 C CG . HIS A 1 166 ? 115.971 -18.361 27.199 1.00 31.08 ? 490 HIS A CG 1 ATOM 1224 N ND1 . HIS A 1 166 ? 115.005 -18.303 26.214 1.00 31.90 ? 490 HIS A ND1 1 ATOM 1225 C CD2 . HIS A 1 166 ? 115.311 -18.272 28.378 1.00 32.68 ? 490 HIS A CD2 1 ATOM 1226 C CE1 . HIS A 1 166 ? 113.815 -18.188 26.775 1.00 31.40 ? 490 HIS A CE1 1 ATOM 1227 N NE2 . HIS A 1 166 ? 113.972 -18.160 28.087 1.00 32.16 ? 490 HIS A NE2 1 ATOM 1228 N N . SER A 1 167 ? 118.312 -20.529 28.979 1.00 28.65 ? 491 SER A N 1 ATOM 1229 C CA . SER A 1 167 ? 118.085 -21.210 30.247 1.00 28.07 ? 491 SER A CA 1 ATOM 1230 C C . SER A 1 167 ? 118.007 -20.144 31.313 1.00 28.38 ? 491 SER A C 1 ATOM 1231 O O . SER A 1 167 ? 118.948 -19.362 31.430 1.00 30.00 ? 491 SER A O 1 ATOM 1232 C CB . SER A 1 167 ? 119.287 -22.080 30.526 1.00 28.06 ? 491 SER A CB 1 ATOM 1233 O OG . SER A 1 167 ? 119.121 -22.703 31.759 1.00 30.51 ? 491 SER A OG 1 ATOM 1234 N N . THR A 1 168 ? 116.913 -20.091 32.068 1.00 27.10 ? 492 THR A N 1 ATOM 1235 C CA . THR A 1 168 ? 116.718 -19.032 33.055 1.00 26.45 ? 492 THR A CA 1 ATOM 1236 C C . THR A 1 168 ? 116.617 -19.640 34.447 1.00 26.08 ? 492 THR A C 1 ATOM 1237 O O . THR A 1 168 ? 115.901 -20.619 34.653 1.00 26.17 ? 492 THR A O 1 ATOM 1238 C CB . THR A 1 168 ? 115.433 -18.207 32.758 1.00 26.82 ? 492 THR A CB 1 ATOM 1239 O OG1 . THR A 1 168 ? 115.540 -17.599 31.464 1.00 27.79 ? 492 THR A OG1 1 ATOM 1240 C CG2 . THR A 1 168 ? 115.199 -17.098 33.796 1.00 23.92 ? 492 THR A CG2 1 ATOM 1241 N N . THR A 1 169 ? 117.328 -19.072 35.415 1.00 27.06 ? 493 THR A N 1 ATOM 1242 C CA . THR A 1 169 ? 117.349 -19.673 36.775 1.00 28.81 ? 493 THR A CA 1 ATOM 1243 C C . THR A 1 169 ? 116.057 -19.359 37.552 1.00 29.32 ? 493 THR A C 1 ATOM 1244 O O . THR A 1 169 ? 115.203 -18.599 37.110 1.00 26.41 ? 493 THR A O 1 ATOM 1245 C CB . THR A 1 169 ? 118.569 -19.225 37.638 1.00 27.15 ? 493 THR A CB 1 ATOM 1246 O OG1 . THR A 1 169 ? 118.545 -17.803 37.793 1.00 30.48 ? 493 THR A OG1 1 ATOM 1247 C CG2 . THR A 1 169 ? 119.883 -19.588 36.985 1.00 26.21 ? 493 THR A CG2 1 ATOM 1248 N N . GLN A 1 170 ? 115.913 -19.974 38.714 1.00 31.22 ? 494 GLN A N 1 ATOM 1249 C CA . GLN A 1 170 ? 114.705 -19.807 39.498 1.00 33.84 ? 494 GLN A CA 1 ATOM 1250 C C . GLN A 1 170 ? 114.887 -18.616 40.410 1.00 33.04 ? 494 GLN A C 1 ATOM 1251 O O . GLN A 1 170 ? 115.989 -18.400 40.915 1.00 32.68 ? 494 GLN A O 1 ATOM 1252 C CB . GLN A 1 170 ? 114.418 -21.055 40.330 1.00 36.40 ? 494 GLN A CB 1 ATOM 1253 C CG . GLN A 1 170 ? 115.549 -21.427 41.270 1.00 38.18 ? 494 GLN A CG 1 ATOM 1254 C CD . GLN A 1 170 ? 115.236 -22.696 42.052 1.00 40.85 ? 494 GLN A CD 1 ATOM 1255 O OE1 . GLN A 1 170 ? 114.138 -22.854 42.629 1.00 40.83 ? 494 GLN A OE1 1 ATOM 1256 N NE2 . GLN A 1 170 ? 116.209 -23.613 42.075 1.00 42.39 ? 494 GLN A NE2 1 ATOM 1257 N N . PRO A 1 171 ? 113.812 -17.837 40.617 1.00 32.66 ? 495 PRO A N 1 ATOM 1258 C CA . PRO A 1 171 ? 113.857 -16.671 41.494 1.00 33.94 ? 495 PRO A CA 1 ATOM 1259 C C . PRO A 1 171 ? 114.467 -16.969 42.860 1.00 35.65 ? 495 PRO A C 1 ATOM 1260 O O . PRO A 1 171 ? 113.933 -17.762 43.630 1.00 36.49 ? 495 PRO A O 1 ATOM 1261 C CB . PRO A 1 171 ? 112.390 -16.282 41.618 1.00 33.12 ? 495 PRO A CB 1 ATOM 1262 C CG . PRO A 1 171 ? 111.781 -16.730 40.388 1.00 32.62 ? 495 PRO A CG 1 ATOM 1263 C CD . PRO A 1 171 ? 112.472 -18.019 40.037 1.00 32.71 ? 495 PRO A CD 1 ATOM 1264 N N . ARG A 1 172 ? 115.616 -16.360 43.121 1.00 38.81 ? 496 ARG A N 1 ATOM 1265 C CA . ARG A 1 172 ? 116.301 -16.451 44.407 1.00 40.80 ? 496 ARG A CA 1 ATOM 1266 C C . ARG A 1 172 ? 116.190 -15.091 45.080 1.00 41.66 ? 496 ARG A C 1 ATOM 1267 O O . ARG A 1 172 ? 116.090 -14.065 44.398 1.00 40.52 ? 496 ARG A O 1 ATOM 1268 C CB . ARG A 1 172 ? 117.785 -16.723 44.207 1.00 42.01 ? 496 ARG A CB 1 ATOM 1269 C CG . ARG A 1 172 ? 118.186 -18.166 44.164 1.00 44.46 ? 496 ARG A CG 1 ATOM 1270 C CD . ARG A 1 172 ? 119.639 -18.281 43.688 1.00 46.80 ? 496 ARG A CD 1 ATOM 1271 N NE . ARG A 1 172 ? 120.229 -19.586 43.974 1.00 48.34 ? 496 ARG A NE 1 ATOM 1272 C CZ . ARG A 1 172 ? 120.826 -19.920 45.116 1.00 49.00 ? 496 ARG A CZ 1 ATOM 1273 N NH1 . ARG A 1 172 ? 120.931 -19.040 46.107 1.00 48.69 ? 496 ARG A NH1 1 ATOM 1274 N NH2 . ARG A 1 172 ? 121.330 -21.145 45.255 1.00 49.64 ? 496 ARG A NH2 1 ATOM 1275 N N . LYS A 1 173 ? 116.232 -15.092 46.410 1.00 43.31 ? 497 LYS A N 1 ATOM 1276 C CA . LYS A 1 173 ? 116.087 -13.871 47.188 1.00 44.60 ? 497 LYS A CA 1 ATOM 1277 C C . LYS A 1 173 ? 117.379 -13.073 47.200 1.00 46.05 ? 497 LYS A C 1 ATOM 1278 O O . LYS A 1 173 ? 118.457 -13.601 47.452 1.00 46.42 ? 497 LYS A O 1 ATOM 1279 C CB . LYS A 1 173 ? 115.690 -14.182 48.627 1.00 45.37 ? 497 LYS A CB 1 ATOM 1280 C CG . LYS A 1 173 ? 114.201 -14.421 48.852 1.00 46.30 ? 497 LYS A CG 1 ATOM 1281 C CD . LYS A 1 173 ? 113.983 -14.863 50.308 1.00 47.69 ? 497 LYS A CD 1 ATOM 1282 C CE . LYS A 1 173 ? 112.520 -15.170 50.680 1.00 48.31 ? 497 LYS A CE 1 ATOM 1283 N NZ . LYS A 1 173 ? 112.410 -15.674 52.093 1.00 47.70 ? 497 LYS A NZ 1 ATOM 1284 N N . THR A 1 174 ? 117.254 -11.781 46.926 1.00 47.80 ? 498 THR A N 1 ATOM 1285 C CA . THR A 1 174 ? 118.358 -10.844 47.081 1.00 48.07 ? 498 THR A CA 1 ATOM 1286 C C . THR A 1 174 ? 118.556 -10.546 48.568 1.00 49.45 ? 498 THR A C 1 ATOM 1287 O O . THR A 1 174 ? 117.784 -11.017 49.419 1.00 47.37 ? 498 THR A O 1 ATOM 1288 C CB . THR A 1 174 ? 118.071 -9.526 46.336 1.00 47.82 ? 498 THR A CB 1 ATOM 1289 O OG1 . THR A 1 174 ? 116.971 -8.848 46.965 1.00 48.23 ? 498 THR A OG1 1 ATOM 1290 C CG2 . THR A 1 174 ? 117.745 -9.792 44.860 1.00 46.85 ? 498 THR A CG2 1 ATOM 1291 N N . LYS A 1 175 ? 119.595 -9.762 48.862 1.00 51.36 ? 499 LYS A N 1 ATOM 1292 C CA . LYS A 1 175 ? 119.876 -9.316 50.227 1.00 53.15 ? 499 LYS A CA 1 ATOM 1293 C C . LYS A 1 175 ? 118.844 -8.272 50.657 1.00 52.84 ? 499 LYS A C 1 ATOM 1294 O O . LYS A 1 175 ? 118.472 -8.212 51.827 1.00 53.39 ? 499 LYS A O 1 ATOM 1295 C CB . LYS A 1 175 ? 121.297 -8.737 50.357 1.00 54.66 ? 499 LYS A CB 1 ATOM 1296 C CG . LYS A 1 175 ? 122.433 -9.592 49.774 1.00 55.67 ? 499 LYS A CG 1 ATOM 1297 C CD . LYS A 1 175 ? 122.471 -11.020 50.329 1.00 56.43 ? 499 LYS A CD 1 ATOM 1298 C CE . LYS A 1 175 ? 123.366 -11.931 49.471 1.00 56.54 ? 499 LYS A CE 1 ATOM 1299 N NZ . LYS A 1 175 ? 123.088 -13.389 49.636 1.00 56.28 ? 499 LYS A NZ 1 ATOM 1300 N N . GLY A 1 176 ? 118.387 -7.454 49.711 1.00 52.59 ? 500 GLY A N 1 ATOM 1301 C CA . GLY A 1 176 ? 117.256 -6.565 49.952 1.00 52.00 ? 500 GLY A CA 1 ATOM 1302 C C . GLY A 1 176 ? 116.018 -7.387 50.261 1.00 51.41 ? 500 GLY A C 1 ATOM 1303 O O . GLY A 1 176 ? 116.075 -8.359 51.025 1.00 51.62 ? 500 GLY A O 1 ATOM 1304 N N . SER A 1 177 ? 114.893 -7.002 49.667 1.00 49.27 ? 501 SER A N 1 ATOM 1305 C CA . SER A 1 177 ? 113.638 -7.711 49.896 1.00 46.69 ? 501 SER A CA 1 ATOM 1306 C C . SER A 1 177 ? 113.239 -8.464 48.617 1.00 43.69 ? 501 SER A C 1 ATOM 1307 O O . SER A 1 177 ? 112.415 -9.386 48.654 1.00 42.61 ? 501 SER A O 1 ATOM 1308 C CB . SER A 1 177 ? 112.563 -6.712 50.353 1.00 47.08 ? 501 SER A CB 1 ATOM 1309 O OG . SER A 1 177 ? 111.599 -7.304 51.219 1.00 47.40 ? 501 SER A OG 1 ATOM 1310 N N . GLY A 1 178 ? 113.851 -8.083 47.495 1.00 39.97 ? 502 GLY A N 1 ATOM 1311 C CA . GLY A 1 178 ? 113.404 -8.523 46.179 1.00 36.74 ? 502 GLY A CA 1 ATOM 1312 C C . GLY A 1 178 ? 114.009 -9.846 45.758 1.00 33.57 ? 502 GLY A C 1 ATOM 1313 O O . GLY A 1 178 ? 114.733 -10.467 46.526 1.00 32.07 ? 502 GLY A O 1 ATOM 1314 N N . PHE A 1 179 ? 113.699 -10.264 44.531 1.00 31.05 ? 503 PHE A N 1 ATOM 1315 C CA . PHE A 1 179 ? 114.200 -11.518 43.961 1.00 29.13 ? 503 PHE A CA 1 ATOM 1316 C C . PHE A 1 179 ? 115.140 -11.232 42.784 1.00 27.54 ? 503 PHE A C 1 ATOM 1317 O O . PHE A 1 179 ? 115.115 -10.144 42.184 1.00 25.73 ? 503 PHE A O 1 ATOM 1318 C CB . PHE A 1 179 ? 113.042 -12.404 43.480 1.00 28.97 ? 503 PHE A CB 1 ATOM 1319 C CG . PHE A 1 179 ? 112.079 -12.823 44.572 1.00 29.45 ? 503 PHE A CG 1 ATOM 1320 C CD1 . PHE A 1 179 ? 110.893 -12.122 44.776 1.00 29.54 ? 503 PHE A CD1 1 ATOM 1321 C CD2 . PHE A 1 179 ? 112.351 -13.914 45.395 1.00 29.29 ? 503 PHE A CD2 1 ATOM 1322 C CE1 . PHE A 1 179 ? 109.983 -12.502 45.790 1.00 28.76 ? 503 PHE A CE1 1 ATOM 1323 C CE2 . PHE A 1 179 ? 111.448 -14.301 46.411 1.00 30.03 ? 503 PHE A CE2 1 ATOM 1324 C CZ . PHE A 1 179 ? 110.256 -13.586 46.599 1.00 28.86 ? 503 PHE A CZ 1 ATOM 1325 N N . PHE A 1 180 ? 115.980 -12.208 42.458 1.00 23.84 ? 504 PHE A N 1 ATOM 1326 C CA . PHE A 1 180 ? 116.756 -12.111 41.242 1.00 21.71 ? 504 PHE A CA 1 ATOM 1327 C C . PHE A 1 180 ? 116.729 -13.388 40.429 1.00 22.23 ? 504 PHE A C 1 ATOM 1328 O O . PHE A 1 180 ? 116.418 -14.477 40.905 1.00 21.56 ? 504 PHE A O 1 ATOM 1329 C CB . PHE A 1 180 ? 118.199 -11.714 41.518 1.00 20.46 ? 504 PHE A CB 1 ATOM 1330 C CG . PHE A 1 180 ? 119.035 -12.820 42.072 1.00 19.46 ? 504 PHE A CG 1 ATOM 1331 C CD1 . PHE A 1 180 ? 119.651 -13.723 41.224 1.00 18.43 ? 504 PHE A CD1 1 ATOM 1332 C CD2 . PHE A 1 180 ? 119.216 -12.962 43.447 1.00 18.99 ? 504 PHE A CD2 1 ATOM 1333 C CE1 . PHE A 1 180 ? 120.436 -14.754 41.735 1.00 18.15 ? 504 PHE A CE1 1 ATOM 1334 C CE2 . PHE A 1 180 ? 120.004 -13.981 43.958 1.00 17.56 ? 504 PHE A CE2 1 ATOM 1335 C CZ . PHE A 1 180 ? 120.609 -14.877 43.101 1.00 18.04 ? 504 PHE A CZ 1 ATOM 1336 N N . VAL A 1 181 ? 117.061 -13.221 39.166 1.00 22.51 ? 505 VAL A N 1 ATOM 1337 C CA . VAL A 1 181 ? 117.113 -14.323 38.252 1.00 23.16 ? 505 VAL A CA 1 ATOM 1338 C C . VAL A 1 181 ? 118.175 -14.009 37.214 1.00 21.38 ? 505 VAL A C 1 ATOM 1339 O O . VAL A 1 181 ? 118.349 -12.839 36.832 1.00 18.40 ? 505 VAL A O 1 ATOM 1340 C CB . VAL A 1 181 ? 115.760 -14.503 37.544 1.00 24.57 ? 505 VAL A CB 1 ATOM 1341 C CG1 . VAL A 1 181 ? 115.464 -13.366 36.632 1.00 23.02 ? 505 VAL A CG1 1 ATOM 1342 C CG2 . VAL A 1 181 ? 115.833 -15.692 36.673 1.00 29.95 ? 505 VAL A CG2 1 ATOM 1343 N N . PHE A 1 182 ? 118.876 -15.053 36.768 1.00 21.92 ? 506 PHE A N 1 ATOM 1344 C CA . PHE A 1 182 ? 119.827 -14.950 35.654 1.00 21.61 ? 506 PHE A CA 1 ATOM 1345 C C . PHE A 1 182 ? 119.283 -15.757 34.477 1.00 22.76 ? 506 PHE A C 1 ATOM 1346 O O . PHE A 1 182 ? 118.556 -16.733 34.639 1.00 26.24 ? 506 PHE A O 1 ATOM 1347 C CB . PHE A 1 182 ? 121.189 -15.551 36.005 1.00 22.06 ? 506 PHE A CB 1 ATOM 1348 C CG . PHE A 1 182 ? 122.045 -14.716 36.911 1.00 23.85 ? 506 PHE A CG 1 ATOM 1349 C CD1 . PHE A 1 182 ? 121.986 -14.866 38.292 1.00 25.73 ? 506 PHE A CD1 1 ATOM 1350 C CD2 . PHE A 1 182 ? 122.971 -13.831 36.395 1.00 24.53 ? 506 PHE A CD2 1 ATOM 1351 C CE1 . PHE A 1 182 ? 122.816 -14.104 39.140 1.00 25.01 ? 506 PHE A CE1 1 ATOM 1352 C CE2 . PHE A 1 182 ? 123.788 -13.076 37.228 1.00 24.74 ? 506 PHE A CE2 1 ATOM 1353 C CZ . PHE A 1 182 ? 123.714 -13.225 38.604 1.00 24.31 ? 506 PHE A CZ 1 ATOM 1354 N N . SER A 1 183 ? 119.684 -15.363 33.282 1.00 24.03 ? 507 SER A N 1 ATOM 1355 C CA . SER A 1 183 ? 119.300 -16.014 32.049 1.00 21.24 ? 507 SER A CA 1 ATOM 1356 C C . SER A 1 183 ? 120.504 -16.047 31.118 1.00 20.78 ? 507 SER A C 1 ATOM 1357 O O . SER A 1 183 ? 121.126 -15.034 30.867 1.00 18.49 ? 507 SER A O 1 ATOM 1358 C CB . SER A 1 183 ? 118.186 -15.198 31.408 1.00 21.05 ? 507 SER A CB 1 ATOM 1359 O OG . SER A 1 183 ? 117.560 -15.893 30.336 1.00 24.09 ? 507 SER A OG 1 ATOM 1360 N N . ARG A 1 184 ? 120.819 -17.229 30.606 1.00 21.98 ? 508 ARG A N 1 ATOM 1361 C CA . ARG A 1 184 ? 121.914 -17.439 29.687 1.00 21.60 ? 508 ARG A CA 1 ATOM 1362 C C . ARG A 1 184 ? 121.415 -17.826 28.290 1.00 23.37 ? 508 ARG A C 1 ATOM 1363 O O . ARG A 1 184 ? 120.528 -18.678 28.146 1.00 23.45 ? 508 ARG A O 1 ATOM 1364 C CB . ARG A 1 184 ? 122.756 -18.563 30.252 1.00 22.68 ? 508 ARG A CB 1 ATOM 1365 C CG . ARG A 1 184 ? 124.088 -18.800 29.598 1.00 23.34 ? 508 ARG A CG 1 ATOM 1366 C CD . ARG A 1 184 ? 124.689 -20.045 30.194 1.00 24.00 ? 508 ARG A CD 1 ATOM 1367 N NE . ARG A 1 184 ? 125.854 -20.541 29.458 1.00 25.54 ? 508 ARG A NE 1 ATOM 1368 C CZ . ARG A 1 184 ? 125.795 -21.396 28.444 1.00 26.59 ? 508 ARG A CZ 1 ATOM 1369 N NH1 . ARG A 1 184 ? 124.634 -21.838 28.000 1.00 28.04 ? 508 ARG A NH1 1 ATOM 1370 N NH2 . ARG A 1 184 ? 126.900 -21.800 27.860 1.00 27.21 ? 508 ARG A NH2 1 ATOM 1371 N N . LEU A 1 185 ? 121.963 -17.171 27.262 1.00 24.35 ? 509 LEU A N 1 ATOM 1372 C CA . LEU A 1 185 ? 121.730 -17.546 25.859 1.00 24.36 ? 509 LEU A CA 1 ATOM 1373 C C . LEU A 1 185 ? 123.037 -17.610 25.054 1.00 25.58 ? 509 LEU A C 1 ATOM 1374 O O . LEU A 1 185 ? 123.730 -16.609 24.911 1.00 26.45 ? 509 LEU A O 1 ATOM 1375 C CB . LEU A 1 185 ? 120.816 -16.508 25.233 1.00 23.91 ? 509 LEU A CB 1 ATOM 1376 C CG . LEU A 1 185 ? 120.522 -16.617 23.737 1.00 24.02 ? 509 LEU A CG 1 ATOM 1377 C CD1 . LEU A 1 185 ? 119.749 -17.876 23.393 1.00 22.84 ? 509 LEU A CD1 1 ATOM 1378 C CD2 . LEU A 1 185 ? 119.781 -15.368 23.232 1.00 22.26 ? 509 LEU A CD2 1 ATOM 1379 N N . GLU A 1 186 ? 123.381 -18.779 24.533 1.00 24.87 ? 510 GLU A N 1 ATOM 1380 C CA . GLU A 1 186 ? 124.507 -18.917 23.631 1.00 26.31 ? 510 GLU A CA 1 ATOM 1381 C C . GLU A 1 186 ? 124.052 -18.479 22.238 1.00 25.64 ? 510 GLU A C 1 ATOM 1382 O O . GLU A 1 186 ? 123.000 -18.910 21.764 1.00 24.42 ? 510 GLU A O 1 ATOM 1383 C CB . GLU A 1 186 ? 124.946 -20.386 23.513 1.00 29.88 ? 510 GLU A CB 1 ATOM 1384 C CG . GLU A 1 186 ? 125.406 -21.079 24.796 1.00 34.24 ? 510 GLU A CG 1 ATOM 1385 C CD . GLU A 1 186 ? 125.821 -22.549 24.563 1.00 38.56 ? 510 GLU A CD 1 ATOM 1386 O OE1 . GLU A 1 186 ? 126.641 -22.778 23.629 1.00 40.90 ? 510 GLU A OE1 1 ATOM 1387 O OE2 . GLU A 1 186 ? 125.328 -23.459 25.301 1.00 38.05 ? 510 GLU A OE2 1 ATOM 1388 N N . VAL A 1 187 ? 124.856 -17.655 21.573 1.00 23.05 ? 511 VAL A N 1 ATOM 1389 C CA . VAL A 1 187 ? 124.545 -17.256 20.216 1.00 22.75 ? 511 VAL A CA 1 ATOM 1390 C C . VAL A 1 187 ? 125.658 -17.647 19.259 1.00 23.26 ? 511 VAL A C 1 ATOM 1391 O O . VAL A 1 187 ? 126.767 -17.946 19.682 1.00 22.39 ? 511 VAL A O 1 ATOM 1392 C CB . VAL A 1 187 ? 124.338 -15.731 20.121 1.00 21.93 ? 511 VAL A CB 1 ATOM 1393 C CG1 . VAL A 1 187 ? 123.188 -15.324 21.026 1.00 18.85 ? 511 VAL A CG1 1 ATOM 1394 C CG2 . VAL A 1 187 ? 125.657 -14.993 20.423 1.00 18.50 ? 511 VAL A CG2 1 ATOM 1395 N N . THR A 1 188 ? 125.368 -17.644 17.962 1.00 24.14 ? 512 THR A N 1 ATOM 1396 C CA . THR A 1 188 ? 126.394 -18.049 16.995 1.00 23.38 ? 512 THR A CA 1 ATOM 1397 C C . THR A 1 188 ? 126.943 -16.812 16.325 1.00 22.51 ? 512 THR A C 1 ATOM 1398 O O . THR A 1 188 ? 126.348 -15.737 16.374 1.00 25.24 ? 512 THR A O 1 ATOM 1399 C CB . THR A 1 188 ? 125.828 -18.970 15.905 1.00 21.69 ? 512 THR A CB 1 ATOM 1400 O OG1 . THR A 1 188 ? 124.861 -18.239 15.155 1.00 22.07 ? 512 THR A OG1 1 ATOM 1401 C CG2 . THR A 1 188 ? 125.187 -20.238 16.485 1.00 19.57 ? 512 THR A CG2 1 ATOM 1402 N N . ARG A 1 189 ? 128.070 -16.967 15.662 1.00 21.53 ? 513 ARG A N 1 ATOM 1403 C CA . ARG A 1 189 ? 128.637 -15.878 14.911 1.00 21.63 ? 513 ARG A CA 1 ATOM 1404 C C . ARG A 1 189 ? 127.754 -15.528 13.717 1.00 21.02 ? 513 ARG A C 1 ATOM 1405 O O . ARG A 1 189 ? 127.657 -14.375 13.313 1.00 21.52 ? 513 ARG A O 1 ATOM 1406 C CB . ARG A 1 189 ? 130.033 -16.270 14.454 1.00 22.78 ? 513 ARG A CB 1 ATOM 1407 C CG . ARG A 1 189 ? 130.729 -15.254 13.576 1.00 23.76 ? 513 ARG A CG 1 ATOM 1408 C CD . ARG A 1 189 ? 132.234 -15.549 13.452 1.00 24.59 ? 513 ARG A CD 1 ATOM 1409 N NE . ARG A 1 189 ? 132.560 -15.318 12.053 1.00 26.09 ? 513 ARG A NE 1 ATOM 1410 C CZ . ARG A 1 189 ? 132.744 -16.267 11.148 1.00 25.61 ? 513 ARG A CZ 1 ATOM 1411 N NH1 . ARG A 1 189 ? 132.719 -17.551 11.450 1.00 26.01 ? 513 ARG A NH1 1 ATOM 1412 N NH2 . ARG A 1 189 ? 132.981 -15.910 9.912 1.00 28.77 ? 513 ARG A NH2 1 ATOM 1413 N N . ALA A 1 190 ? 127.108 -16.519 13.131 1.00 20.97 ? 514 ALA A N 1 ATOM 1414 C CA . ALA A 1 190 ? 126.181 -16.227 12.052 1.00 22.43 ? 514 ALA A CA 1 ATOM 1415 C C . ALA A 1 190 ? 125.126 -15.222 12.532 1.00 22.43 ? 514 ALA A C 1 ATOM 1416 O O . ALA A 1 190 ? 124.711 -14.337 11.792 1.00 23.32 ? 514 ALA A O 1 ATOM 1417 C CB . ALA A 1 190 ? 125.511 -17.506 11.575 1.00 22.09 ? 514 ALA A CB 1 ATOM 1418 N N . GLU A 1 191 ? 124.690 -15.343 13.780 1.00 22.04 ? 515 GLU A N 1 ATOM 1419 C CA . GLU A 1 191 ? 123.613 -14.487 14.261 1.00 21.41 ? 515 GLU A CA 1 ATOM 1420 C C . GLU A 1 191 ? 124.032 -13.041 14.471 1.00 20.07 ? 515 GLU A C 1 ATOM 1421 O O . GLU A 1 191 ? 123.328 -12.134 14.032 1.00 22.09 ? 515 GLU A O 1 ATOM 1422 C CB . GLU A 1 191 ? 122.985 -15.056 15.543 1.00 21.89 ? 515 GLU A CB 1 ATOM 1423 C CG . GLU A 1 191 ? 122.128 -16.252 15.287 1.00 21.61 ? 515 GLU A CG 1 ATOM 1424 C CD . GLU A 1 191 ? 121.697 -16.954 16.560 1.00 23.47 ? 515 GLU A CD 1 ATOM 1425 O OE1 . GLU A 1 191 ? 120.523 -17.392 16.630 1.00 25.43 ? 515 GLU A OE1 1 ATOM 1426 O OE2 . GLU A 1 191 ? 122.530 -17.067 17.488 1.00 24.17 ? 515 GLU A OE2 1 ATOM 1427 N N . TRP A 1 192 ? 125.151 -12.809 15.147 1.00 20.22 ? 516 TRP A N 1 ATOM 1428 C CA . TRP A 1 192 ? 125.566 -11.436 15.424 1.00 21.35 ? 516 TRP A CA 1 ATOM 1429 C C . TRP A 1 192 ? 126.115 -10.736 14.190 1.00 23.54 ? 516 TRP A C 1 ATOM 1430 O O . TRP A 1 192 ? 126.136 -9.505 14.139 1.00 27.14 ? 516 TRP A O 1 ATOM 1431 C CB . TRP A 1 192 ? 126.526 -11.334 16.621 1.00 20.69 ? 516 TRP A CB 1 ATOM 1432 C CG . TRP A 1 192 ? 127.950 -11.688 16.356 1.00 21.40 ? 516 TRP A CG 1 ATOM 1433 C CD1 . TRP A 1 192 ? 128.831 -11.018 15.549 1.00 22.34 ? 516 TRP A CD1 1 ATOM 1434 C CD2 . TRP A 1 192 ? 128.669 -12.806 16.897 1.00 21.29 ? 516 TRP A CD2 1 ATOM 1435 N NE1 . TRP A 1 192 ? 130.061 -11.649 15.564 1.00 23.02 ? 516 TRP A NE1 1 ATOM 1436 C CE2 . TRP A 1 192 ? 129.983 -12.750 16.380 1.00 22.45 ? 516 TRP A CE2 1 ATOM 1437 C CE3 . TRP A 1 192 ? 128.333 -13.842 17.775 1.00 20.23 ? 516 TRP A CE3 1 ATOM 1438 C CZ2 . TRP A 1 192 ? 130.960 -13.688 16.722 1.00 22.14 ? 516 TRP A CZ2 1 ATOM 1439 C CZ3 . TRP A 1 192 ? 129.291 -14.767 18.112 1.00 21.06 ? 516 TRP A CZ3 1 ATOM 1440 C CH2 . TRP A 1 192 ? 130.591 -14.692 17.585 1.00 22.04 ? 516 TRP A CH2 1 ATOM 1441 N N . GLU A 1 193 ? 126.514 -11.495 13.176 1.00 24.93 ? 517 GLU A N 1 ATOM 1442 C CA . GLU A 1 193 ? 126.927 -10.883 11.903 1.00 25.82 ? 517 GLU A CA 1 ATOM 1443 C C . GLU A 1 193 ? 125.734 -10.473 11.054 1.00 26.09 ? 517 GLU A C 1 ATOM 1444 O O . GLU A 1 193 ? 125.811 -9.522 10.278 1.00 27.51 ? 517 GLU A O 1 ATOM 1445 C CB . GLU A 1 193 ? 127.864 -11.812 11.131 1.00 26.47 ? 517 GLU A CB 1 ATOM 1446 C CG . GLU A 1 193 ? 129.263 -11.889 11.798 1.00 26.90 ? 517 GLU A CG 1 ATOM 1447 C CD . GLU A 1 193 ? 130.200 -12.858 11.120 1.00 26.89 ? 517 GLU A CD 1 ATOM 1448 O OE1 . GLU A 1 193 ? 129.781 -13.485 10.122 1.00 28.08 ? 517 GLU A OE1 1 ATOM 1449 O OE2 . GLU A 1 193 ? 131.350 -12.986 11.588 1.00 26.50 ? 517 GLU A OE2 1 ATOM 1450 N N . GLN A 1 194 ? 124.626 -11.182 11.214 1.00 25.26 ? 518 GLN A N 1 ATOM 1451 C CA . GLN A 1 194 ? 123.367 -10.782 10.597 1.00 26.07 ? 518 GLN A CA 1 ATOM 1452 C C . GLN A 1 194 ? 122.847 -9.488 11.244 1.00 26.24 ? 518 GLN A C 1 ATOM 1453 O O . GLN A 1 194 ? 122.278 -8.625 10.573 1.00 24.10 ? 518 GLN A O 1 ATOM 1454 C CB . GLN A 1 194 ? 122.350 -11.921 10.750 1.00 27.33 ? 518 GLN A CB 1 ATOM 1455 C CG . GLN A 1 194 ? 121.002 -11.693 10.103 1.00 27.39 ? 518 GLN A CG 1 ATOM 1456 C CD . GLN A 1 194 ? 119.948 -11.307 11.112 1.00 28.89 ? 518 GLN A CD 1 ATOM 1457 O OE1 . GLN A 1 194 ? 119.646 -12.053 12.061 1.00 27.42 ? 518 GLN A OE1 1 ATOM 1458 N NE2 . GLN A 1 194 ? 119.378 -10.120 10.922 1.00 30.44 ? 518 GLN A NE2 1 ATOM 1459 N N . LYS A 1 195 ? 123.064 -9.355 12.556 1.00 27.19 ? 519 LYS A N 1 ATOM 1460 C CA . LYS A 1 195 ? 122.625 -8.179 13.327 1.00 25.67 ? 519 LYS A CA 1 ATOM 1461 C C . LYS A 1 195 ? 123.151 -8.332 14.750 1.00 24.22 ? 519 LYS A C 1 ATOM 1462 O O . LYS A 1 195 ? 122.748 -9.258 15.451 1.00 22.10 ? 519 LYS A O 1 ATOM 1463 C CB . LYS A 1 195 ? 121.093 -8.102 13.351 1.00 26.95 ? 519 LYS A CB 1 ATOM 1464 C CG . LYS A 1 195 ? 120.499 -6.871 14.049 1.00 27.48 ? 519 LYS A CG 1 ATOM 1465 C CD . LYS A 1 195 ? 120.819 -5.609 13.288 1.00 28.60 ? 519 LYS A CD 1 ATOM 1466 C CE . LYS A 1 195 ? 120.315 -4.375 14.015 1.00 29.81 ? 519 LYS A CE 1 ATOM 1467 N NZ . LYS A 1 195 ? 118.897 -4.505 14.454 1.00 30.00 ? 519 LYS A NZ 1 ATOM 1468 N N . ASP A 1 196 ? 124.031 -7.423 15.161 1.00 24.18 ? 520 ASP A N 1 ATOM 1469 C CA . ASP A 1 196 ? 124.769 -7.525 16.421 1.00 25.04 ? 520 ASP A CA 1 ATOM 1470 C C . ASP A 1 196 ? 124.059 -6.805 17.576 1.00 27.85 ? 520 ASP A C 1 ATOM 1471 O O . ASP A 1 196 ? 124.576 -5.831 18.136 1.00 27.22 ? 520 ASP A O 1 ATOM 1472 C CB . ASP A 1 196 ? 126.183 -6.957 16.273 1.00 24.24 ? 520 ASP A CB 1 ATOM 1473 C CG . ASP A 1 196 ? 127.089 -7.318 17.444 1.00 24.81 ? 520 ASP A CG 1 ATOM 1474 O OD1 . ASP A 1 196 ? 128.186 -6.736 17.584 1.00 24.37 ? 520 ASP A OD1 1 ATOM 1475 O OD2 . ASP A 1 196 ? 126.702 -8.195 18.246 1.00 25.33 ? 520 ASP A OD2 1 ATOM 1476 N N . GLU A 1 197 ? 122.884 -7.313 17.940 1.00 28.64 ? 521 GLU A N 1 ATOM 1477 C CA . GLU A 1 197 ? 122.028 -6.699 18.946 1.00 29.27 ? 521 GLU A CA 1 ATOM 1478 C C . GLU A 1 197 ? 121.078 -7.809 19.384 1.00 27.92 ? 521 GLU A C 1 ATOM 1479 O O . GLU A 1 197 ? 120.353 -8.384 18.568 1.00 25.39 ? 521 GLU A O 1 ATOM 1480 C CB . GLU A 1 197 ? 121.270 -5.486 18.372 1.00 31.27 ? 521 GLU A CB 1 ATOM 1481 C CG . GLU A 1 197 ? 120.538 -4.575 19.394 1.00 33.11 ? 521 GLU A CG 1 ATOM 1482 C CD . GLU A 1 197 ? 119.820 -3.341 18.764 1.00 36.50 ? 521 GLU A CD 1 ATOM 1483 O OE1 . GLU A 1 197 ? 119.132 -3.482 17.724 1.00 38.03 ? 521 GLU A OE1 1 ATOM 1484 O OE2 . GLU A 1 197 ? 119.911 -2.208 19.312 1.00 37.29 ? 521 GLU A OE2 1 ATOM 1485 N N . PHE A 1 198 ? 121.129 -8.129 20.674 1.00 27.54 ? 522 PHE A N 1 ATOM 1486 C CA . PHE A 1 198 ? 120.267 -9.143 21.269 1.00 26.86 ? 522 PHE A CA 1 ATOM 1487 C C . PHE A 1 198 ? 119.596 -8.504 22.477 1.00 28.81 ? 522 PHE A C 1 ATOM 1488 O O . PHE A 1 198 ? 120.250 -7.796 23.268 1.00 31.55 ? 522 PHE A O 1 ATOM 1489 C CB . PHE A 1 198 ? 121.076 -10.369 21.692 1.00 25.44 ? 522 PHE A CB 1 ATOM 1490 C CG . PHE A 1 198 ? 121.751 -11.073 20.549 1.00 25.58 ? 522 PHE A CG 1 ATOM 1491 C CD1 . PHE A 1 198 ? 122.945 -10.605 20.032 1.00 26.04 ? 522 PHE A CD1 1 ATOM 1492 C CD2 . PHE A 1 198 ? 121.192 -12.196 19.986 1.00 26.26 ? 522 PHE A CD2 1 ATOM 1493 C CE1 . PHE A 1 198 ? 123.556 -11.231 18.975 1.00 26.11 ? 522 PHE A CE1 1 ATOM 1494 C CE2 . PHE A 1 198 ? 121.807 -12.827 18.928 1.00 26.77 ? 522 PHE A CE2 1 ATOM 1495 C CZ . PHE A 1 198 ? 122.994 -12.339 18.418 1.00 26.41 ? 522 PHE A CZ 1 ATOM 1496 N N . ILE A 1 199 ? 118.298 -8.729 22.626 1.00 26.45 ? 523 ILE A N 1 ATOM 1497 C CA . ILE A 1 199 ? 117.586 -8.057 23.692 1.00 27.05 ? 523 ILE A CA 1 ATOM 1498 C C . ILE A 1 199 ? 117.066 -9.077 24.694 1.00 26.96 ? 523 ILE A C 1 ATOM 1499 O O . ILE A 1 199 ? 116.444 -10.072 24.315 1.00 24.81 ? 523 ILE A O 1 ATOM 1500 C CB . ILE A 1 199 ? 116.425 -7.229 23.153 1.00 28.18 ? 523 ILE A CB 1 ATOM 1501 C CG1 . ILE A 1 199 ? 116.961 -6.085 22.278 1.00 29.32 ? 523 ILE A CG1 1 ATOM 1502 C CG2 . ILE A 1 199 ? 115.607 -6.709 24.320 1.00 29.35 ? 523 ILE A CG2 1 ATOM 1503 C CD1 . ILE A 1 199 ? 115.931 -5.459 21.395 1.00 29.30 ? 523 ILE A CD1 1 ATOM 1504 N N . CYS A 1 200 ? 117.345 -8.814 25.966 1.00 25.06 ? 524 CYS A N 1 ATOM 1505 C CA . CYS A 1 200 ? 116.793 -9.591 27.045 1.00 26.28 ? 524 CYS A CA 1 ATOM 1506 C C . CYS A 1 200 ? 115.596 -8.834 27.535 1.00 26.63 ? 524 CYS A C 1 ATOM 1507 O O . CYS A 1 200 ? 115.724 -7.680 27.954 1.00 27.76 ? 524 CYS A O 1 ATOM 1508 C CB . CYS A 1 200 ? 117.830 -9.724 28.167 1.00 29.10 ? 524 CYS A CB 1 ATOM 1509 S SG . CYS A 1 200 ? 117.170 -10.282 29.748 1.00 29.06 ? 524 CYS A SG 1 ATOM 1510 N N . ARG A 1 201 ? 114.422 -9.446 27.471 1.00 27.44 ? 525 ARG A N 1 ATOM 1511 C CA . ARG A 1 201 ? 113.207 -8.736 27.901 1.00 29.56 ? 525 ARG A CA 1 ATOM 1512 C C . ARG A 1 201 ? 112.531 -9.408 29.091 1.00 28.20 ? 525 ARG A C 1 ATOM 1513 O O . ARG A 1 201 ? 112.275 -10.612 29.062 1.00 29.40 ? 525 ARG A O 1 ATOM 1514 C CB . ARG A 1 201 ? 112.206 -8.604 26.750 1.00 31.52 ? 525 ARG A CB 1 ATOM 1515 C CG . ARG A 1 201 ? 110.813 -8.199 27.197 1.00 32.93 ? 525 ARG A CG 1 ATOM 1516 C CD . ARG A 1 201 ? 110.119 -7.369 26.153 1.00 34.10 ? 525 ARG A CD 1 ATOM 1517 N NE . ARG A 1 201 ? 109.715 -8.156 25.009 1.00 36.31 ? 525 ARG A NE 1 ATOM 1518 C CZ . ARG A 1 201 ? 109.543 -7.656 23.786 1.00 37.89 ? 525 ARG A CZ 1 ATOM 1519 N NH1 . ARG A 1 201 ? 109.772 -6.368 23.539 1.00 37.41 ? 525 ARG A NH1 1 ATOM 1520 N NH2 . ARG A 1 201 ? 109.162 -8.463 22.799 1.00 38.56 ? 525 ARG A NH2 1 ATOM 1521 N N . ALA A 1 202 ? 112.248 -8.614 30.114 1.00 25.26 ? 526 ALA A N 1 ATOM 1522 C CA . ALA A 1 202 ? 111.612 -9.080 31.332 1.00 25.61 ? 526 ALA A CA 1 ATOM 1523 C C . ALA A 1 202 ? 110.172 -8.613 31.366 1.00 25.87 ? 526 ALA A C 1 ATOM 1524 O O . ALA A 1 202 ? 109.923 -7.427 31.325 1.00 27.89 ? 526 ALA A O 1 ATOM 1525 C CB . ALA A 1 202 ? 112.338 -8.523 32.546 1.00 24.43 ? 526 ALA A CB 1 ATOM 1526 N N . VAL A 1 203 ? 109.211 -9.525 31.443 1.00 26.71 ? 527 VAL A N 1 ATOM 1527 C CA . VAL A 1 203 ? 107.844 -9.118 31.693 1.00 25.69 ? 527 VAL A CA 1 ATOM 1528 C C . VAL A 1 203 ? 107.450 -9.339 33.150 1.00 25.95 ? 527 VAL A C 1 ATOM 1529 O O . VAL A 1 203 ? 107.621 -10.413 33.717 1.00 26.48 ? 527 VAL A O 1 ATOM 1530 C CB . VAL A 1 203 ? 106.857 -9.777 30.739 1.00 25.66 ? 527 VAL A CB 1 ATOM 1531 C CG1 . VAL A 1 203 ? 105.421 -9.344 31.089 1.00 22.93 ? 527 VAL A CG1 1 ATOM 1532 C CG2 . VAL A 1 203 ? 107.210 -9.363 29.290 1.00 24.33 ? 527 VAL A CG2 1 ATOM 1533 N N . HIS A 1 204 ? 106.944 -8.282 33.771 1.00 25.22 ? 528 HIS A N 1 ATOM 1534 C CA . HIS A 1 204 ? 106.687 -8.310 35.191 1.00 24.22 ? 528 HIS A CA 1 ATOM 1535 C C . HIS A 1 204 ? 105.576 -7.350 35.564 1.00 24.25 ? 528 HIS A C 1 ATOM 1536 O O . HIS A 1 204 ? 105.479 -6.266 35.021 1.00 23.26 ? 528 HIS A O 1 ATOM 1537 C CB . HIS A 1 204 ? 107.916 -7.883 35.978 1.00 24.27 ? 528 HIS A CB 1 ATOM 1538 C CG . HIS A 1 204 ? 107.776 -8.117 37.450 1.00 23.47 ? 528 HIS A CG 1 ATOM 1539 N ND1 . HIS A 1 204 ? 107.144 -7.232 38.289 1.00 22.97 ? 528 HIS A ND1 1 ATOM 1540 C CD2 . HIS A 1 204 ? 108.171 -9.154 38.222 1.00 23.06 ? 528 HIS A CD2 1 ATOM 1541 C CE1 . HIS A 1 204 ? 107.172 -7.706 39.521 1.00 24.93 ? 528 HIS A CE1 1 ATOM 1542 N NE2 . HIS A 1 204 ? 107.794 -8.870 39.508 1.00 23.71 ? 528 HIS A NE2 1 ATOM 1543 N N . GLU A 1 205 ? 104.780 -7.777 36.528 1.00 25.37 ? 529 GLU A N 1 ATOM 1544 C CA . GLU A 1 205 ? 103.591 -7.086 36.983 1.00 28.75 ? 529 GLU A CA 1 ATOM 1545 C C . GLU A 1 205 ? 103.830 -5.604 37.276 1.00 29.88 ? 529 GLU A C 1 ATOM 1546 O O . GLU A 1 205 ? 102.949 -4.772 37.064 1.00 28.30 ? 529 GLU A O 1 ATOM 1547 C CB . GLU A 1 205 ? 103.150 -7.802 38.252 1.00 30.05 ? 529 GLU A CB 1 ATOM 1548 C CG . GLU A 1 205 ? 101.799 -7.429 38.786 1.00 32.94 ? 529 GLU A CG 1 ATOM 1549 C CD . GLU A 1 205 ? 101.443 -8.295 39.990 1.00 34.38 ? 529 GLU A CD 1 ATOM 1550 O OE1 . GLU A 1 205 ? 102.147 -9.318 40.196 1.00 34.92 ? 529 GLU A OE1 1 ATOM 1551 O OE2 . GLU A 1 205 ? 100.490 -7.940 40.714 1.00 33.28 ? 529 GLU A OE2 1 ATOM 1552 N N . ALA A 1 206 ? 105.033 -5.294 37.754 1.00 31.15 ? 530 ALA A N 1 ATOM 1553 C CA . ALA A 1 206 ? 105.333 -3.997 38.339 1.00 32.38 ? 530 ALA A CA 1 ATOM 1554 C C . ALA A 1 206 ? 106.278 -3.189 37.469 1.00 34.10 ? 530 ALA A C 1 ATOM 1555 O O . ALA A 1 206 ? 106.780 -2.147 37.888 1.00 33.36 ? 530 ALA A O 1 ATOM 1556 C CB . ALA A 1 206 ? 105.934 -4.167 39.734 1.00 32.11 ? 530 ALA A CB 1 ATOM 1557 N N . ALA A 1 207 ? 106.515 -3.662 36.253 1.00 35.79 ? 531 ALA A N 1 ATOM 1558 C CA . ALA A 1 207 ? 107.367 -2.933 35.333 1.00 37.18 ? 531 ALA A CA 1 ATOM 1559 C C . ALA A 1 207 ? 106.539 -1.959 34.505 1.00 39.27 ? 531 ALA A C 1 ATOM 1560 O O . ALA A 1 207 ? 106.116 -2.257 33.399 1.00 40.00 ? 531 ALA A O 1 ATOM 1561 C CB . ALA A 1 207 ? 108.092 -3.899 34.430 1.00 36.56 ? 531 ALA A CB 1 ATOM 1562 N N . SER A 1 208 ? 106.301 -0.780 35.044 1.00 42.57 ? 532 SER A N 1 ATOM 1563 C CA . SER A 1 208 ? 105.643 0.255 34.266 1.00 45.49 ? 532 SER A CA 1 ATOM 1564 C C . SER A 1 208 ? 106.540 0.712 33.108 1.00 46.56 ? 532 SER A C 1 ATOM 1565 O O . SER A 1 208 ? 107.765 0.559 33.165 1.00 47.16 ? 532 SER A O 1 ATOM 1566 C CB . SER A 1 208 ? 105.254 1.405 35.193 1.00 46.61 ? 532 SER A CB 1 ATOM 1567 O OG . SER A 1 208 ? 104.317 0.946 36.165 1.00 47.57 ? 532 SER A OG 1 ATOM 1568 N N . PRO A 1 209 ? 105.936 1.258 32.036 1.00 46.74 ? 533 PRO A N 1 ATOM 1569 C CA . PRO A 1 209 ? 104.517 1.580 31.901 1.00 46.47 ? 533 PRO A CA 1 ATOM 1570 C C . PRO A 1 209 ? 103.666 0.477 31.271 1.00 45.18 ? 533 PRO A C 1 ATOM 1571 O O . PRO A 1 209 ? 102.440 0.633 31.170 1.00 45.36 ? 533 PRO A O 1 ATOM 1572 C CB . PRO A 1 209 ? 104.542 2.800 30.971 1.00 47.12 ? 533 PRO A CB 1 ATOM 1573 C CG . PRO A 1 209 ? 105.745 2.554 30.062 1.00 47.08 ? 533 PRO A CG 1 ATOM 1574 C CD . PRO A 1 209 ? 106.702 1.655 30.835 1.00 47.08 ? 533 PRO A CD 1 ATOM 1575 N N . SER A 1 210 ? 104.313 -0.610 30.856 1.00 42.57 ? 534 SER A N 1 ATOM 1576 C CA . SER A 1 210 ? 103.705 -1.607 29.980 1.00 40.56 ? 534 SER A CA 1 ATOM 1577 C C . SER A 1 210 ? 103.978 -3.040 30.463 1.00 38.52 ? 534 SER A C 1 ATOM 1578 O O . SER A 1 210 ? 103.914 -3.997 29.689 1.00 35.35 ? 534 SER A O 1 ATOM 1579 C CB . SER A 1 210 ? 104.326 -1.426 28.602 1.00 41.43 ? 534 SER A CB 1 ATOM 1580 O OG . SER A 1 210 ? 105.747 -1.409 28.746 1.00 41.82 ? 534 SER A OG 1 ATOM 1581 N N . GLN A 1 211 ? 104.295 -3.178 31.747 1.00 37.53 ? 535 GLN A N 1 ATOM 1582 C CA . GLN A 1 211 ? 104.641 -4.469 32.352 1.00 37.62 ? 535 GLN A CA 1 ATOM 1583 C C . GLN A 1 211 ? 105.977 -5.059 31.813 1.00 35.99 ? 535 GLN A C 1 ATOM 1584 O O . GLN A 1 211 ? 106.303 -6.227 32.042 1.00 34.97 ? 535 GLN A O 1 ATOM 1585 C CB . GLN A 1 211 ? 103.470 -5.464 32.199 1.00 39.53 ? 535 GLN A CB 1 ATOM 1586 C CG . GLN A 1 211 ? 102.037 -4.852 32.117 1.00 41.56 ? 535 GLN A CG 1 ATOM 1587 C CD . GLN A 1 211 ? 101.718 -3.894 33.250 1.00 43.54 ? 535 GLN A CD 1 ATOM 1588 O OE1 . GLN A 1 211 ? 101.988 -4.163 34.424 1.00 46.96 ? 535 GLN A OE1 1 ATOM 1589 N NE2 . GLN A 1 211 ? 101.142 -2.760 32.900 1.00 44.45 ? 535 GLN A NE2 1 ATOM 1590 N N . THR A 1 212 ? 106.760 -4.240 31.109 1.00 34.15 ? 536 THR A N 1 ATOM 1591 C CA . THR A 1 212 ? 107.896 -4.704 30.285 1.00 31.84 ? 536 THR A CA 1 ATOM 1592 C C . THR A 1 212 ? 109.148 -3.838 30.492 1.00 30.46 ? 536 THR A C 1 ATOM 1593 O O . THR A 1 212 ? 109.089 -2.619 30.418 1.00 29.88 ? 536 THR A O 1 ATOM 1594 C CB . THR A 1 212 ? 107.537 -4.658 28.756 1.00 30.95 ? 536 THR A CB 1 ATOM 1595 O OG1 . THR A 1 212 ? 106.618 -5.705 28.431 1.00 30.51 ? 536 THR A OG1 1 ATOM 1596 C CG2 . THR A 1 212 ? 108.751 -4.827 27.879 1.00 28.98 ? 536 THR A CG2 1 ATOM 1597 N N . VAL A 1 213 ? 110.292 -4.461 30.739 1.00 29.58 ? 537 VAL A N 1 ATOM 1598 C CA . VAL A 1 213 ? 111.549 -3.745 30.666 1.00 30.21 ? 537 VAL A CA 1 ATOM 1599 C C . VAL A 1 213 ? 112.584 -4.648 30.034 1.00 30.18 ? 537 VAL A C 1 ATOM 1600 O O . VAL A 1 213 ? 112.634 -5.833 30.346 1.00 29.74 ? 537 VAL A O 1 ATOM 1601 C CB . VAL A 1 213 ? 112.082 -3.286 32.053 1.00 31.54 ? 537 VAL A CB 1 ATOM 1602 C CG1 . VAL A 1 213 ? 111.494 -1.924 32.428 1.00 34.73 ? 537 VAL A CG1 1 ATOM 1603 C CG2 . VAL A 1 213 ? 111.792 -4.316 33.131 1.00 32.30 ? 537 VAL A CG2 1 ATOM 1604 N N . GLN A 1 214 ? 113.435 -4.057 29.199 1.00 28.79 ? 538 GLN A N 1 ATOM 1605 C CA . GLN A 1 214 ? 114.358 -4.800 28.371 1.00 29.47 ? 538 GLN A CA 1 ATOM 1606 C C . GLN A 1 214 ? 115.689 -4.081 28.224 1.00 29.04 ? 538 GLN A C 1 ATOM 1607 O O . GLN A 1 214 ? 115.779 -2.871 28.401 1.00 30.62 ? 538 GLN A O 1 ATOM 1608 C CB . GLN A 1 214 ? 113.757 -5.067 26.993 1.00 29.29 ? 538 GLN A CB 1 ATOM 1609 C CG . GLN A 1 214 ? 113.472 -3.806 26.214 1.00 30.23 ? 538 GLN A CG 1 ATOM 1610 C CD . GLN A 1 214 ? 112.777 -4.100 24.914 1.00 30.39 ? 538 GLN A CD 1 ATOM 1611 O OE1 . GLN A 1 214 ? 111.770 -4.813 24.886 1.00 33.30 ? 538 GLN A OE1 1 ATOM 1612 N NE2 . GLN A 1 214 ? 113.305 -3.562 23.829 1.00 29.29 ? 538 GLN A NE2 1 ATOM 1613 N N . ARG A 1 215 ? 116.740 -4.835 27.930 1.00 28.36 ? 539 ARG A N 1 ATOM 1614 C CA . ARG A 1 215 ? 118.050 -4.224 27.758 1.00 30.27 ? 539 ARG A CA 1 ATOM 1615 C C . ARG A 1 215 ? 118.772 -5.011 26.681 1.00 28.06 ? 539 ARG A C 1 ATOM 1616 O O . ARG A 1 215 ? 118.691 -6.221 26.648 1.00 28.18 ? 539 ARG A O 1 ATOM 1617 C CB . ARG A 1 215 ? 118.812 -4.138 29.086 1.00 31.50 ? 539 ARG A CB 1 ATOM 1618 C CG . ARG A 1 215 ? 119.702 -2.903 29.217 1.00 34.55 ? 539 ARG A CG 1 ATOM 1619 C CD . ARG A 1 215 ? 119.498 -2.071 30.498 1.00 36.68 ? 539 ARG A CD 1 ATOM 1620 N NE . ARG A 1 215 ? 118.416 -1.077 30.408 1.00 39.08 ? 539 ARG A NE 1 ATOM 1621 C CZ . ARG A 1 215 ? 117.286 -1.109 31.124 1.00 40.91 ? 539 ARG A CZ 1 ATOM 1622 N NH1 . ARG A 1 215 ? 117.056 -2.069 31.997 1.00 44.24 ? 539 ARG A NH1 1 ATOM 1623 N NH2 . ARG A 1 215 ? 116.353 -0.199 30.979 1.00 40.64 ? 539 ARG A NH2 1 ATOM 1624 N N . ALA A 1 216 ? 119.399 -4.309 25.749 1.00 27.61 ? 540 ALA A N 1 ATOM 1625 C CA . ALA A 1 216 ? 120.124 -4.932 24.646 1.00 26.64 ? 540 ALA A CA 1 ATOM 1626 C C . ALA A 1 216 ? 121.583 -5.158 25.015 1.00 26.90 ? 540 ALA A C 1 ATOM 1627 O O . ALA A 1 216 ? 122.072 -4.623 25.997 1.00 26.65 ? 540 ALA A O 1 ATOM 1628 C CB . ALA A 1 216 ? 120.081 -4.039 23.469 1.00 25.55 ? 540 ALA A CB 1 ATOM 1629 N N . VAL A 1 217 ? 122.276 -5.951 24.206 1.00 26.84 ? 541 VAL A N 1 ATOM 1630 C CA . VAL A 1 217 ? 123.713 -6.130 24.354 1.00 25.60 ? 541 VAL A CA 1 ATOM 1631 C C . VAL A 1 217 ? 124.287 -6.560 23.025 1.00 25.17 ? 541 VAL A C 1 ATOM 1632 O O . VAL A 1 217 ? 123.647 -7.257 22.250 1.00 25.48 ? 541 VAL A O 1 ATOM 1633 C CB . VAL A 1 217 ? 124.077 -7.234 25.361 1.00 26.92 ? 541 VAL A CB 1 ATOM 1634 C CG1 . VAL A 1 217 ? 123.387 -8.519 25.025 1.00 21.70 ? 541 VAL A CG1 1 ATOM 1635 C CG2 . VAL A 1 217 ? 125.606 -7.421 25.398 1.00 28.26 ? 541 VAL A CG2 1 ATOM 1636 N N . SER A 1 218 ? 125.512 -6.149 22.760 1.00 26.47 ? 542 SER A N 1 ATOM 1637 C CA . SER A 1 218 ? 126.136 -6.494 21.503 1.00 25.54 ? 542 SER A CA 1 ATOM 1638 C C . SER A 1 218 ? 127.370 -7.307 21.759 1.00 24.81 ? 542 SER A C 1 ATOM 1639 O O . SER A 1 218 ? 128.056 -7.115 22.760 1.00 23.26 ? 542 SER A O 1 ATOM 1640 C CB . SER A 1 218 ? 126.462 -5.240 20.717 1.00 25.96 ? 542 SER A CB 1 ATOM 1641 O OG . SER A 1 218 ? 125.243 -4.588 20.426 1.00 27.32 ? 542 SER A OG 1 ATOM 1642 N N . VAL A 1 219 ? 127.631 -8.239 20.848 1.00 26.13 ? 543 VAL A N 1 ATOM 1643 C CA . VAL A 1 219 ? 128.816 -9.052 20.968 1.00 26.41 ? 543 VAL A CA 1 ATOM 1644 C C . VAL A 1 219 ? 130.011 -8.172 20.696 1.00 28.81 ? 543 VAL A C 1 ATOM 1645 O O . VAL A 1 219 ? 131.010 -8.263 21.422 1.00 29.45 ? 543 VAL A O 1 ATOM 1646 C CB . VAL A 1 219 ? 128.859 -10.261 20.016 1.00 26.14 ? 543 VAL A CB 1 ATOM 1647 C CG1 . VAL A 1 219 ? 130.285 -10.861 20.058 1.00 25.27 ? 543 VAL A CG1 1 ATOM 1648 C CG2 . VAL A 1 219 ? 127.774 -11.337 20.393 1.00 21.31 ? 543 VAL A CG2 1 ATOM 1649 N N . ASN A 1 220 ? 129.896 -7.324 19.669 1.00 29.65 ? 544 ASN A N 1 ATOM 1650 C CA . ASN A 1 220 ? 131.003 -6.476 19.233 1.00 30.68 ? 544 ASN A CA 1 ATOM 1651 C C . ASN A 1 220 ? 132.196 -7.278 18.674 1.00 31.78 ? 544 ASN A C 1 ATOM 1652 O O . ASN A 1 220 ? 132.130 -7.935 17.625 1.00 32.89 ? 544 ASN A O 1 ATOM 1653 C CB . ASN A 1 220 ? 131.471 -5.593 20.399 1.00 30.51 ? 544 ASN A CB 1 ATOM 1654 C CG . ASN A 1 220 ? 130.534 -4.411 20.667 1.00 30.57 ? 544 ASN A CG 1 ATOM 1655 O OD1 . ASN A 1 220 ? 129.949 -3.828 19.752 1.00 29.27 ? 544 ASN A OD1 1 ATOM 1656 N ND2 . ASN A 1 220 ? 130.401 -4.049 21.937 1.00 30.65 ? 544 ASN A ND2 1 ATOM 1657 N N . VAL B 1 12 ? 109.288 -39.931 55.278 1.00 32.35 ? 336 VAL B N 1 ATOM 1658 C CA . VAL B 1 12 ? 110.709 -39.739 55.712 1.00 33.36 ? 336 VAL B CA 1 ATOM 1659 C C . VAL B 1 12 ? 111.666 -39.866 54.537 1.00 32.33 ? 336 VAL B C 1 ATOM 1660 O O . VAL B 1 12 ? 111.614 -40.839 53.782 1.00 31.06 ? 336 VAL B O 1 ATOM 1661 C CB . VAL B 1 12 ? 111.137 -40.769 56.779 1.00 33.69 ? 336 VAL B CB 1 ATOM 1662 C CG1 . VAL B 1 12 ? 112.573 -40.523 57.196 1.00 32.98 ? 336 VAL B CG1 1 ATOM 1663 C CG2 . VAL B 1 12 ? 110.195 -40.710 57.983 1.00 34.12 ? 336 VAL B CG2 1 ATOM 1664 N N . SER B 1 13 ? 112.544 -38.881 54.395 1.00 31.84 ? 337 SER B N 1 ATOM 1665 C CA . SER B 1 13 ? 113.460 -38.842 53.262 1.00 32.88 ? 337 SER B CA 1 ATOM 1666 C C . SER B 1 13 ? 114.868 -38.504 53.729 1.00 31.52 ? 337 SER B C 1 ATOM 1667 O O . SER B 1 13 ? 115.053 -37.890 54.764 1.00 32.43 ? 337 SER B O 1 ATOM 1668 C CB . SER B 1 13 ? 112.977 -37.827 52.219 1.00 33.79 ? 337 SER B CB 1 ATOM 1669 O OG . SER B 1 13 ? 113.038 -36.515 52.748 1.00 35.14 ? 337 SER B OG 1 ATOM 1670 N N . ALA B 1 14 ? 115.861 -38.908 52.954 1.00 31.52 ? 338 ALA B N 1 ATOM 1671 C CA . ALA B 1 14 ? 117.242 -38.869 53.379 1.00 30.36 ? 338 ALA B CA 1 ATOM 1672 C C . ALA B 1 14 ? 118.081 -38.352 52.234 1.00 30.60 ? 338 ALA B C 1 ATOM 1673 O O . ALA B 1 14 ? 117.833 -38.694 51.089 1.00 28.61 ? 338 ALA B O 1 ATOM 1674 C CB . ALA B 1 14 ? 117.690 -40.253 53.747 1.00 31.20 ? 338 ALA B CB 1 ATOM 1675 N N . TYR B 1 15 ? 119.079 -37.528 52.535 1.00 32.54 ? 339 TYR B N 1 ATOM 1676 C CA . TYR B 1 15 ? 119.906 -36.922 51.485 1.00 34.00 ? 339 TYR B CA 1 ATOM 1677 C C . TYR B 1 15 ? 121.370 -36.983 51.897 1.00 33.16 ? 339 TYR B C 1 ATOM 1678 O O . TYR B 1 15 ? 121.705 -36.827 53.071 1.00 29.29 ? 339 TYR B O 1 ATOM 1679 C CB . TYR B 1 15 ? 119.477 -35.479 51.189 1.00 35.93 ? 339 TYR B CB 1 ATOM 1680 C CG . TYR B 1 15 ? 118.024 -35.350 50.765 1.00 39.22 ? 339 TYR B CG 1 ATOM 1681 C CD1 . TYR B 1 15 ? 117.044 -34.989 51.677 1.00 39.96 ? 339 TYR B CD1 1 ATOM 1682 C CD2 . TYR B 1 15 ? 117.634 -35.605 49.449 1.00 41.02 ? 339 TYR B CD2 1 ATOM 1683 C CE1 . TYR B 1 15 ? 115.724 -34.875 51.297 1.00 41.51 ? 339 TYR B CE1 1 ATOM 1684 C CE2 . TYR B 1 15 ? 116.314 -35.496 49.061 1.00 41.90 ? 339 TYR B CE2 1 ATOM 1685 C CZ . TYR B 1 15 ? 115.362 -35.133 49.991 1.00 42.28 ? 339 TYR B CZ 1 ATOM 1686 O OH . TYR B 1 15 ? 114.044 -35.027 49.613 1.00 42.70 ? 339 TYR B OH 1 ATOM 1687 N N . LEU B 1 16 ? 122.233 -37.247 50.922 1.00 33.20 ? 340 LEU B N 1 ATOM 1688 C CA . LEU B 1 16 ? 123.661 -37.382 51.188 1.00 33.96 ? 340 LEU B CA 1 ATOM 1689 C C . LEU B 1 16 ? 124.424 -36.587 50.144 1.00 35.12 ? 340 LEU B C 1 ATOM 1690 O O . LEU B 1 16 ? 124.259 -36.750 48.922 1.00 34.19 ? 340 LEU B O 1 ATOM 1691 C CB . LEU B 1 16 ? 124.105 -38.846 51.232 1.00 32.34 ? 340 LEU B CB 1 ATOM 1692 C CG . LEU B 1 16 ? 125.535 -39.182 51.694 1.00 32.29 ? 340 LEU B CG 1 ATOM 1693 C CD1 . LEU B 1 16 ? 125.930 -38.607 53.053 1.00 30.23 ? 340 LEU B CD1 1 ATOM 1694 C CD2 . LEU B 1 16 ? 125.727 -40.705 51.691 1.00 30.28 ? 340 LEU B CD2 1 ATOM 1695 N N . SER B 1 17 ? 125.249 -35.680 50.643 1.00 35.06 ? 341 SER B N 1 ATOM 1696 C CA . SER B 1 17 ? 125.905 -34.744 49.754 1.00 35.37 ? 341 SER B CA 1 ATOM 1697 C C . SER B 1 17 ? 127.334 -35.177 49.537 1.00 33.45 ? 341 SER B C 1 ATOM 1698 O O . SER B 1 17 ? 127.846 -36.026 50.241 1.00 34.12 ? 341 SER B O 1 ATOM 1699 C CB . SER B 1 17 ? 125.868 -33.347 50.360 1.00 36.09 ? 341 SER B CB 1 ATOM 1700 O OG . SER B 1 17 ? 126.498 -33.405 51.625 1.00 39.05 ? 341 SER B OG 1 ATOM 1701 N N . ARG B 1 18 ? 127.974 -34.584 48.546 1.00 32.64 ? 342 ARG B N 1 ATOM 1702 C CA . ARG B 1 18 ? 129.389 -34.770 48.345 1.00 29.75 ? 342 ARG B CA 1 ATOM 1703 C C . ARG B 1 18 ? 130.078 -33.590 48.982 1.00 27.70 ? 342 ARG B C 1 ATOM 1704 O O . ARG B 1 18 ? 129.443 -32.615 49.334 1.00 28.57 ? 342 ARG B O 1 ATOM 1705 C CB . ARG B 1 18 ? 129.684 -34.829 46.853 1.00 29.81 ? 342 ARG B CB 1 ATOM 1706 C CG . ARG B 1 18 ? 129.094 -36.046 46.153 1.00 30.62 ? 342 ARG B CG 1 ATOM 1707 C CD . ARG B 1 18 ? 129.428 -36.064 44.673 1.00 31.71 ? 342 ARG B CD 1 ATOM 1708 N NE . ARG B 1 18 ? 128.731 -34.971 43.997 1.00 33.70 ? 342 ARG B NE 1 ATOM 1709 C CZ . ARG B 1 18 ? 127.527 -35.081 43.442 1.00 34.02 ? 342 ARG B CZ 1 ATOM 1710 N NH1 . ARG B 1 18 ? 126.876 -36.239 43.466 1.00 34.97 ? 342 ARG B NH1 1 ATOM 1711 N NH2 . ARG B 1 18 ? 126.977 -34.029 42.860 1.00 34.14 ? 342 ARG B NH2 1 ATOM 1712 N N . PRO B 1 19 ? 131.401 -33.655 49.114 1.00 28.42 ? 343 PRO B N 1 ATOM 1713 C CA . PRO B 1 19 ? 132.127 -32.537 49.689 1.00 26.70 ? 343 PRO B CA 1 ATOM 1714 C C . PRO B 1 19 ? 132.184 -31.369 48.722 1.00 25.76 ? 343 PRO B C 1 ATOM 1715 O O . PRO B 1 19 ? 132.124 -31.565 47.524 1.00 26.91 ? 343 PRO B O 1 ATOM 1716 C CB . PRO B 1 19 ? 133.525 -33.109 49.912 1.00 27.37 ? 343 PRO B CB 1 ATOM 1717 C CG . PRO B 1 19 ? 133.408 -34.609 49.691 1.00 26.79 ? 343 PRO B CG 1 ATOM 1718 C CD . PRO B 1 19 ? 132.308 -34.744 48.711 1.00 27.21 ? 343 PRO B CD 1 ATOM 1719 N N . SER B 1 20 ? 132.286 -30.152 49.231 1.00 24.98 ? 344 SER B N 1 ATOM 1720 C CA . SER B 1 20 ? 132.449 -29.013 48.369 1.00 24.70 ? 344 SER B CA 1 ATOM 1721 C C . SER B 1 20 ? 133.878 -28.968 47.822 1.00 23.44 ? 344 SER B C 1 ATOM 1722 O O . SER B 1 20 ? 134.848 -29.234 48.532 1.00 21.43 ? 344 SER B O 1 ATOM 1723 C CB . SER B 1 20 ? 132.146 -27.729 49.151 1.00 25.13 ? 344 SER B CB 1 ATOM 1724 O OG . SER B 1 20 ? 133.221 -27.416 50.020 1.00 26.65 ? 344 SER B OG 1 ATOM 1725 N N . PRO B 1 21 ? 134.012 -28.601 46.546 1.00 22.65 ? 345 PRO B N 1 ATOM 1726 C CA . PRO B 1 21 ? 135.350 -28.464 45.990 1.00 22.12 ? 345 PRO B CA 1 ATOM 1727 C C . PRO B 1 21 ? 136.222 -27.556 46.830 1.00 23.34 ? 345 PRO B C 1 ATOM 1728 O O . PRO B 1 21 ? 137.416 -27.823 46.984 1.00 22.35 ? 345 PRO B O 1 ATOM 1729 C CB . PRO B 1 21 ? 135.097 -27.932 44.588 1.00 21.65 ? 345 PRO B CB 1 ATOM 1730 C CG . PRO B 1 21 ? 133.718 -28.531 44.207 1.00 20.67 ? 345 PRO B CG 1 ATOM 1731 C CD . PRO B 1 21 ? 132.956 -28.607 45.516 1.00 21.52 ? 345 PRO B CD 1 ATOM 1732 N N . PHE B 1 22 ? 135.628 -26.506 47.388 1.00 24.86 ? 346 PHE B N 1 ATOM 1733 C CA . PHE B 1 22 ? 136.358 -25.596 48.255 1.00 24.08 ? 346 PHE B CA 1 ATOM 1734 C C . PHE B 1 22 ? 136.973 -26.376 49.416 1.00 24.31 ? 346 PHE B C 1 ATOM 1735 O O . PHE B 1 22 ? 138.183 -26.339 49.627 1.00 23.75 ? 346 PHE B O 1 ATOM 1736 C CB . PHE B 1 22 ? 135.419 -24.522 48.774 1.00 24.44 ? 346 PHE B CB 1 ATOM 1737 C CG . PHE B 1 22 ? 136.055 -23.560 49.739 1.00 25.24 ? 346 PHE B CG 1 ATOM 1738 C CD1 . PHE B 1 22 ? 137.067 -22.705 49.333 1.00 25.66 ? 346 PHE B CD1 1 ATOM 1739 C CD2 . PHE B 1 22 ? 135.613 -23.493 51.050 1.00 25.50 ? 346 PHE B CD2 1 ATOM 1740 C CE1 . PHE B 1 22 ? 137.637 -21.800 50.230 1.00 26.00 ? 346 PHE B CE1 1 ATOM 1741 C CE2 . PHE B 1 22 ? 136.174 -22.597 51.940 1.00 25.84 ? 346 PHE B CE2 1 ATOM 1742 C CZ . PHE B 1 22 ? 137.185 -21.753 51.534 1.00 25.78 ? 346 PHE B CZ 1 ATOM 1743 N N . ASP B 1 23 ? 136.149 -27.096 50.166 1.00 24.58 ? 347 ASP B N 1 ATOM 1744 C CA . ASP B 1 23 ? 136.672 -27.831 51.315 1.00 24.64 ? 347 ASP B CA 1 ATOM 1745 C C . ASP B 1 23 ? 137.634 -28.923 50.874 1.00 23.90 ? 347 ASP B C 1 ATOM 1746 O O . ASP B 1 23 ? 138.603 -29.242 51.557 1.00 25.08 ? 347 ASP B O 1 ATOM 1747 C CB . ASP B 1 23 ? 135.546 -28.490 52.096 1.00 24.90 ? 347 ASP B CB 1 ATOM 1748 C CG . ASP B 1 23 ? 134.778 -27.517 52.936 1.00 26.00 ? 347 ASP B CG 1 ATOM 1749 O OD1 . ASP B 1 23 ? 133.750 -27.943 53.497 1.00 26.70 ? 347 ASP B OD1 1 ATOM 1750 O OD2 . ASP B 1 23 ? 135.186 -26.338 53.018 1.00 27.41 ? 347 ASP B OD2 1 ATOM 1751 N N . LEU B 1 24 ? 137.364 -29.514 49.727 1.00 22.63 ? 348 LEU B N 1 ATOM 1752 C CA . LEU B 1 24 ? 138.156 -30.632 49.298 1.00 24.07 ? 348 LEU B CA 1 ATOM 1753 C C . LEU B 1 24 ? 139.523 -30.182 48.785 1.00 25.68 ? 348 LEU B C 1 ATOM 1754 O O . LEU B 1 24 ? 140.520 -30.851 49.033 1.00 26.77 ? 348 LEU B O 1 ATOM 1755 C CB . LEU B 1 24 ? 137.375 -31.389 48.244 1.00 24.97 ? 348 LEU B CB 1 ATOM 1756 C CG . LEU B 1 24 ? 137.909 -32.661 47.610 1.00 26.25 ? 348 LEU B CG 1 ATOM 1757 C CD1 . LEU B 1 24 ? 138.225 -33.784 48.611 1.00 24.23 ? 348 LEU B CD1 1 ATOM 1758 C CD2 . LEU B 1 24 ? 136.849 -33.049 46.561 1.00 25.05 ? 348 LEU B CD2 1 ATOM 1759 N N . PHE B 1 25 ? 139.590 -29.048 48.091 1.00 26.14 ? 349 PHE B N 1 ATOM 1760 C CA . PHE B 1 25 ? 140.823 -28.669 47.407 1.00 25.75 ? 349 PHE B CA 1 ATOM 1761 C C . PHE B 1 25 ? 141.525 -27.454 48.031 1.00 28.11 ? 349 PHE B C 1 ATOM 1762 O O . PHE B 1 25 ? 142.740 -27.328 47.913 1.00 27.29 ? 349 PHE B O 1 ATOM 1763 C CB . PHE B 1 25 ? 140.573 -28.373 45.927 1.00 23.49 ? 349 PHE B CB 1 ATOM 1764 C CG . PHE B 1 25 ? 140.046 -29.539 45.135 1.00 21.59 ? 349 PHE B CG 1 ATOM 1765 C CD1 . PHE B 1 25 ? 138.813 -29.454 44.497 1.00 20.25 ? 349 PHE B CD1 1 ATOM 1766 C CD2 . PHE B 1 25 ? 140.776 -30.700 45.005 1.00 20.51 ? 349 PHE B CD2 1 ATOM 1767 C CE1 . PHE B 1 25 ? 138.312 -30.513 43.769 1.00 20.20 ? 349 PHE B CE1 1 ATOM 1768 C CE2 . PHE B 1 25 ? 140.278 -31.770 44.265 1.00 19.82 ? 349 PHE B CE2 1 ATOM 1769 C CZ . PHE B 1 25 ? 139.046 -31.672 43.651 1.00 19.74 ? 349 PHE B CZ 1 ATOM 1770 N N . ILE B 1 26 ? 140.775 -26.550 48.655 1.00 28.81 ? 350 ILE B N 1 ATOM 1771 C CA . ILE B 1 26 ? 141.380 -25.336 49.169 1.00 29.92 ? 350 ILE B CA 1 ATOM 1772 C C . ILE B 1 26 ? 141.684 -25.534 50.655 1.00 30.89 ? 350 ILE B C 1 ATOM 1773 O O . ILE B 1 26 ? 142.841 -25.446 51.079 1.00 31.22 ? 350 ILE B O 1 ATOM 1774 C CB . ILE B 1 26 ? 140.472 -24.100 48.947 1.00 31.08 ? 350 ILE B CB 1 ATOM 1775 C CG1 . ILE B 1 26 ? 140.223 -23.875 47.442 1.00 31.62 ? 350 ILE B CG1 1 ATOM 1776 C CG2 . ILE B 1 26 ? 141.102 -22.840 49.574 1.00 29.37 ? 350 ILE B CG2 1 ATOM 1777 C CD1 . ILE B 1 26 ? 141.464 -23.563 46.622 1.00 30.71 ? 350 ILE B CD1 1 ATOM 1778 N N . ARG B 1 27 ? 140.646 -25.822 51.437 1.00 30.02 ? 351 ARG B N 1 ATOM 1779 C CA . ARG B 1 27 ? 140.814 -26.092 52.842 1.00 30.35 ? 351 ARG B CA 1 ATOM 1780 C C . ARG B 1 27 ? 141.363 -27.465 53.122 1.00 30.91 ? 351 ARG B C 1 ATOM 1781 O O . ARG B 1 27 ? 141.937 -27.674 54.178 1.00 32.01 ? 351 ARG B O 1 ATOM 1782 C CB . ARG B 1 27 ? 139.502 -25.941 53.568 1.00 30.16 ? 351 ARG B CB 1 ATOM 1783 C CG . ARG B 1 27 ? 139.089 -24.532 53.589 1.00 31.51 ? 351 ARG B CG 1 ATOM 1784 C CD . ARG B 1 27 ? 137.785 -24.390 54.299 1.00 32.99 ? 351 ARG B CD 1 ATOM 1785 N NE . ARG B 1 27 ? 137.941 -24.553 55.727 1.00 33.41 ? 351 ARG B NE 1 ATOM 1786 C CZ . ARG B 1 27 ? 137.329 -25.494 56.416 1.00 35.66 ? 351 ARG B CZ 1 ATOM 1787 N NH1 . ARG B 1 27 ? 136.542 -26.340 55.782 1.00 36.35 ? 351 ARG B NH1 1 ATOM 1788 N NH2 . ARG B 1 27 ? 137.501 -25.588 57.729 1.00 38.09 ? 351 ARG B NH2 1 ATOM 1789 N N . LYS B 1 28 ? 141.174 -28.390 52.191 1.00 30.82 ? 352 LYS B N 1 ATOM 1790 C CA . LYS B 1 28 ? 141.622 -29.764 52.355 1.00 32.02 ? 352 LYS B CA 1 ATOM 1791 C C . LYS B 1 28 ? 141.134 -30.374 53.657 1.00 31.86 ? 352 LYS B C 1 ATOM 1792 O O . LYS B 1 28 ? 141.842 -31.139 54.290 1.00 33.70 ? 352 LYS B O 1 ATOM 1793 C CB . LYS B 1 28 ? 143.146 -29.850 52.260 1.00 33.73 ? 352 LYS B CB 1 ATOM 1794 C CG . LYS B 1 28 ? 143.668 -29.473 50.873 1.00 35.77 ? 352 LYS B CG 1 ATOM 1795 C CD . LYS B 1 28 ? 145.186 -29.604 50.716 1.00 37.01 ? 352 LYS B CD 1 ATOM 1796 C CE . LYS B 1 28 ? 145.647 -29.226 49.306 1.00 37.67 ? 352 LYS B CE 1 ATOM 1797 N NZ . LYS B 1 28 ? 147.121 -29.420 49.147 1.00 39.75 ? 352 LYS B NZ 1 ATOM 1798 N N . SER B 1 29 ? 139.925 -30.028 54.076 1.00 30.93 ? 353 SER B N 1 ATOM 1799 C CA . SER B 1 29 ? 139.255 -30.810 55.087 1.00 30.60 ? 353 SER B CA 1 ATOM 1800 C C . SER B 1 29 ? 137.832 -31.047 54.602 1.00 27.62 ? 353 SER B C 1 ATOM 1801 O O . SER B 1 29 ? 136.905 -30.335 54.967 1.00 26.01 ? 353 SER B O 1 ATOM 1802 C CB . SER B 1 29 ? 139.280 -30.140 56.450 1.00 30.48 ? 353 SER B CB 1 ATOM 1803 O OG . SER B 1 29 ? 138.403 -29.046 56.395 1.00 36.14 ? 353 SER B OG 1 ATOM 1804 N N . PRO B 1 30 ? 137.669 -32.070 53.763 1.00 25.60 ? 354 PRO B N 1 ATOM 1805 C CA . PRO B 1 30 ? 136.382 -32.357 53.176 1.00 25.20 ? 354 PRO B CA 1 ATOM 1806 C C . PRO B 1 30 ? 135.494 -33.075 54.168 1.00 24.66 ? 354 PRO B C 1 ATOM 1807 O O . PRO B 1 30 ? 136.008 -33.774 55.024 1.00 25.41 ? 354 PRO B O 1 ATOM 1808 C CB . PRO B 1 30 ? 136.739 -33.255 51.982 1.00 25.71 ? 354 PRO B CB 1 ATOM 1809 C CG . PRO B 1 30 ? 138.023 -33.861 52.312 1.00 25.39 ? 354 PRO B CG 1 ATOM 1810 C CD . PRO B 1 30 ? 138.746 -32.900 53.202 1.00 25.71 ? 354 PRO B CD 1 ATOM 1811 N N . THR B 1 31 ? 134.181 -32.896 54.037 1.00 23.77 ? 355 THR B N 1 ATOM 1812 C CA . THR B 1 31 ? 133.190 -33.508 54.894 1.00 22.82 ? 355 THR B CA 1 ATOM 1813 C C . THR B 1 31 ? 131.971 -33.836 54.050 1.00 23.69 ? 355 THR B C 1 ATOM 1814 O O . THR B 1 31 ? 131.775 -33.243 52.979 1.00 25.64 ? 355 THR B O 1 ATOM 1815 C CB . THR B 1 31 ? 132.697 -32.525 55.958 1.00 24.80 ? 355 THR B CB 1 ATOM 1816 O OG1 . THR B 1 31 ? 131.978 -31.489 55.288 1.00 27.36 ? 355 THR B OG1 1 ATOM 1817 C CG2 . THR B 1 31 ? 133.834 -31.940 56.788 1.00 20.53 ? 355 THR B CG2 1 ATOM 1818 N N . ILE B 1 32 ? 131.145 -34.777 54.505 1.00 23.53 ? 356 ILE B N 1 ATOM 1819 C CA . ILE B 1 32 ? 129.863 -35.027 53.835 1.00 23.03 ? 356 ILE B CA 1 ATOM 1820 C C . ILE B 1 32 ? 128.750 -34.951 54.850 1.00 25.17 ? 356 ILE B C 1 ATOM 1821 O O . ILE B 1 32 ? 128.988 -35.096 56.056 1.00 27.82 ? 356 ILE B O 1 ATOM 1822 C CB . ILE B 1 32 ? 129.811 -36.398 53.158 1.00 21.43 ? 356 ILE B CB 1 ATOM 1823 C CG1 . ILE B 1 32 ? 130.146 -37.508 54.165 1.00 18.89 ? 356 ILE B CG1 1 ATOM 1824 C CG2 . ILE B 1 32 ? 130.770 -36.441 51.959 1.00 21.59 ? 356 ILE B CG2 1 ATOM 1825 C CD1 . ILE B 1 32 ? 130.262 -38.916 53.554 1.00 16.68 ? 356 ILE B CD1 1 ATOM 1826 N N . THR B 1 33 ? 127.528 -34.742 54.374 1.00 26.20 ? 357 THR B N 1 ATOM 1827 C CA . THR B 1 33 ? 126.440 -34.489 55.294 1.00 26.43 ? 357 THR B CA 1 ATOM 1828 C C . THR B 1 33 ? 125.262 -35.357 54.917 1.00 27.86 ? 357 THR B C 1 ATOM 1829 O O . THR B 1 33 ? 124.855 -35.427 53.754 1.00 28.66 ? 357 THR B O 1 ATOM 1830 C CB . THR B 1 33 ? 126.083 -32.991 55.341 1.00 26.90 ? 357 THR B CB 1 ATOM 1831 O OG1 . THR B 1 33 ? 127.160 -32.259 55.962 1.00 25.64 ? 357 THR B OG1 1 ATOM 1832 C CG2 . THR B 1 33 ? 124.817 -32.772 56.142 1.00 25.79 ? 357 THR B CG2 1 ATOM 1833 N N . CYS B 1 34 ? 124.751 -36.052 55.923 1.00 29.13 ? 358 CYS B N 1 ATOM 1834 C CA . CYS B 1 34 ? 123.604 -36.930 55.766 1.00 29.94 ? 358 CYS B CA 1 ATOM 1835 C C . CYS B 1 34 ? 122.461 -36.188 56.424 1.00 28.68 ? 358 CYS B C 1 ATOM 1836 O O . CYS B 1 34 ? 122.577 -35.836 57.591 1.00 28.52 ? 358 CYS B O 1 ATOM 1837 C CB . CYS B 1 34 ? 123.836 -38.280 56.448 1.00 31.01 ? 358 CYS B CB 1 ATOM 1838 S SG . CYS B 1 34 ? 122.495 -39.417 56.130 1.00 32.88 ? 358 CYS B SG 1 ATOM 1839 N N . LEU B 1 35 ? 121.409 -35.931 55.651 1.00 28.09 ? 359 LEU B N 1 ATOM 1840 C CA . LEU B 1 35 ? 120.266 -35.139 56.044 1.00 29.26 ? 359 LEU B CA 1 ATOM 1841 C C . LEU B 1 35 ? 118.983 -35.963 55.947 1.00 30.22 ? 359 LEU B C 1 ATOM 1842 O O . LEU B 1 35 ? 118.556 -36.347 54.861 1.00 27.45 ? 359 LEU B O 1 ATOM 1843 C CB . LEU B 1 35 ? 120.190 -33.936 55.113 1.00 30.16 ? 359 LEU B CB 1 ATOM 1844 C CG . LEU B 1 35 ? 119.009 -32.982 55.245 1.00 31.39 ? 359 LEU B CG 1 ATOM 1845 C CD1 . LEU B 1 35 ? 118.846 -32.460 56.665 1.00 31.00 ? 359 LEU B CD1 1 ATOM 1846 C CD2 . LEU B 1 35 ? 119.211 -31.854 54.253 1.00 31.16 ? 359 LEU B CD2 1 ATOM 1847 N N . VAL B 1 36 ? 118.358 -36.255 57.082 1.00 33.60 ? 360 VAL B N 1 ATOM 1848 C CA . VAL B 1 36 ? 117.077 -36.974 57.043 1.00 35.18 ? 360 VAL B CA 1 ATOM 1849 C C . VAL B 1 36 ? 115.955 -36.041 57.447 1.00 35.93 ? 360 VAL B C 1 ATOM 1850 O O . VAL B 1 36 ? 115.989 -35.488 58.537 1.00 36.51 ? 360 VAL B O 1 ATOM 1851 C CB . VAL B 1 36 ? 117.044 -38.282 57.877 1.00 34.77 ? 360 VAL B CB 1 ATOM 1852 C CG1 . VAL B 1 36 ? 118.312 -38.468 58.691 1.00 35.43 ? 360 VAL B CG1 1 ATOM 1853 C CG2 . VAL B 1 36 ? 115.775 -38.332 58.759 1.00 34.97 ? 360 VAL B CG2 1 ATOM 1854 N N . VAL B 1 37 ? 114.987 -35.863 56.552 1.00 37.04 ? 361 VAL B N 1 ATOM 1855 C CA . VAL B 1 37 ? 113.962 -34.836 56.700 1.00 39.71 ? 361 VAL B CA 1 ATOM 1856 C C . VAL B 1 37 ? 112.594 -35.470 56.944 1.00 42.49 ? 361 VAL B C 1 ATOM 1857 O O . VAL B 1 37 ? 112.374 -36.655 56.692 1.00 40.53 ? 361 VAL B O 1 ATOM 1858 C CB . VAL B 1 37 ? 113.851 -33.932 55.419 1.00 40.09 ? 361 VAL B CB 1 ATOM 1859 C CG1 . VAL B 1 37 ? 112.747 -32.889 55.568 1.00 39.90 ? 361 VAL B CG1 1 ATOM 1860 C CG2 . VAL B 1 37 ? 115.154 -33.224 55.101 1.00 38.90 ? 361 VAL B CG2 1 ATOM 1861 N N . ASP B 1 38 ? 111.674 -34.655 57.448 1.00 47.74 ? 362 ASP B N 1 ATOM 1862 C CA . ASP B 1 38 ? 110.241 -34.948 57.393 1.00 51.62 ? 362 ASP B CA 1 ATOM 1863 C C . ASP B 1 38 ? 109.854 -36.036 58.382 1.00 54.28 ? 362 ASP B C 1 ATOM 1864 O O . ASP B 1 38 ? 109.089 -36.946 58.073 1.00 54.44 ? 362 ASP B O 1 ATOM 1865 C CB . ASP B 1 38 ? 109.826 -35.350 55.975 1.00 52.53 ? 362 ASP B CB 1 ATOM 1866 C CG . ASP B 1 38 ? 108.390 -35.004 55.677 1.00 53.51 ? 362 ASP B CG 1 ATOM 1867 O OD1 . ASP B 1 38 ? 108.006 -33.845 55.954 1.00 54.21 ? 362 ASP B OD1 1 ATOM 1868 O OD2 . ASP B 1 38 ? 107.654 -35.885 55.170 1.00 54.96 ? 362 ASP B OD2 1 ATOM 1869 N N . LEU B 1 39 ? 110.388 -35.928 59.588 1.00 58.00 ? 363 LEU B N 1 ATOM 1870 C CA . LEU B 1 39 ? 110.164 -36.940 60.602 1.00 60.83 ? 363 LEU B CA 1 ATOM 1871 C C . LEU B 1 39 ? 109.146 -36.457 61.642 1.00 63.27 ? 363 LEU B C 1 ATOM 1872 O O . LEU B 1 39 ? 109.488 -36.227 62.804 1.00 63.55 ? 363 LEU B O 1 ATOM 1873 C CB . LEU B 1 39 ? 111.504 -37.266 61.253 1.00 61.57 ? 363 LEU B CB 1 ATOM 1874 C CG . LEU B 1 39 ? 111.539 -38.633 61.924 1.00 62.45 ? 363 LEU B CG 1 ATOM 1875 C CD1 . LEU B 1 39 ? 110.457 -39.534 61.282 1.00 63.42 ? 363 LEU B CD1 1 ATOM 1876 C CD2 . LEU B 1 39 ? 112.953 -39.262 61.789 1.00 62.95 ? 363 LEU B CD2 1 ATOM 1877 N N . ALA B 1 40 ? 107.892 -36.309 61.218 1.00 65.53 ? 364 ALA B N 1 ATOM 1878 C CA . ALA B 1 40 ? 106.887 -35.638 62.035 1.00 66.80 ? 364 ALA B CA 1 ATOM 1879 C C . ALA B 1 40 ? 106.904 -36.154 63.478 1.00 68.30 ? 364 ALA B C 1 ATOM 1880 O O . ALA B 1 40 ? 107.268 -35.414 64.397 1.00 68.70 ? 364 ALA B O 1 ATOM 1881 C CB . ALA B 1 40 ? 105.506 -35.789 61.408 1.00 66.46 ? 364 ALA B CB 1 ATOM 1882 N N . PRO B 1 41 ? 106.531 -37.431 63.681 1.00 69.47 ? 365 PRO B N 1 ATOM 1883 C CA . PRO B 1 41 ? 106.331 -37.968 65.033 1.00 69.71 ? 365 PRO B CA 1 ATOM 1884 C C . PRO B 1 41 ? 107.626 -38.197 65.805 1.00 69.66 ? 365 PRO B C 1 ATOM 1885 O O . PRO B 1 41 ? 108.687 -38.392 65.205 1.00 68.69 ? 365 PRO B O 1 ATOM 1886 C CB . PRO B 1 41 ? 105.631 -39.307 64.783 1.00 69.79 ? 365 PRO B CB 1 ATOM 1887 C CG . PRO B 1 41 ? 106.103 -39.722 63.430 1.00 69.74 ? 365 PRO B CG 1 ATOM 1888 C CD . PRO B 1 41 ? 106.303 -38.452 62.641 1.00 69.58 ? 365 PRO B CD 1 ATOM 1889 N N . SER B 1 42 ? 107.517 -38.181 67.132 1.00 69.77 ? 366 SER B N 1 ATOM 1890 C CA . SER B 1 42 ? 108.682 -38.259 68.008 1.00 69.59 ? 366 SER B CA 1 ATOM 1891 C C . SER B 1 42 ? 108.783 -39.603 68.733 1.00 69.10 ? 366 SER B C 1 ATOM 1892 O O . SER B 1 42 ? 107.811 -40.122 69.287 1.00 68.39 ? 366 SER B O 1 ATOM 1893 C CB . SER B 1 42 ? 108.683 -37.103 69.019 1.00 69.73 ? 366 SER B CB 1 ATOM 1894 O OG . SER B 1 42 ? 109.151 -35.900 68.424 1.00 69.81 ? 366 SER B OG 1 ATOM 1895 N N . LYS B 1 43 ? 109.990 -40.155 68.707 1.00 68.73 ? 367 LYS B N 1 ATOM 1896 C CA . LYS B 1 43 ? 110.323 -41.364 69.447 1.00 68.41 ? 367 LYS B CA 1 ATOM 1897 C C . LYS B 1 43 ? 111.853 -41.420 69.578 1.00 68.61 ? 367 LYS B C 1 ATOM 1898 O O . LYS B 1 43 ? 112.514 -42.320 69.047 1.00 69.11 ? 367 LYS B O 1 ATOM 1899 C CB . LYS B 1 43 ? 109.754 -42.591 68.731 1.00 67.73 ? 367 LYS B CB 1 ATOM 1900 C CG . LYS B 1 43 ? 109.947 -43.894 69.480 1.00 67.27 ? 367 LYS B CG 1 ATOM 1901 C CD . LYS B 1 43 ? 108.946 -44.949 69.026 1.00 66.87 ? 367 LYS B CD 1 ATOM 1902 C CE . LYS B 1 43 ? 109.255 -46.309 69.647 1.00 66.50 ? 367 LYS B CE 1 ATOM 1903 N NZ . LYS B 1 43 ? 108.155 -47.297 69.461 1.00 65.73 ? 367 LYS B NZ 1 ATOM 1904 N N . GLY B 1 44 ? 112.389 -40.426 70.290 1.00 67.93 ? 368 GLY B N 1 ATOM 1905 C CA . GLY B 1 44 ? 113.828 -40.187 70.449 1.00 66.74 ? 368 GLY B CA 1 ATOM 1906 C C . GLY B 1 44 ? 114.784 -41.325 70.142 1.00 65.46 ? 368 GLY B C 1 ATOM 1907 O O . GLY B 1 44 ? 115.357 -41.921 71.057 1.00 65.78 ? 368 GLY B O 1 ATOM 1908 N N . THR B 1 45 ? 114.971 -41.619 68.857 1.00 63.44 ? 369 THR B N 1 ATOM 1909 C CA . THR B 1 45 ? 115.920 -42.651 68.432 1.00 61.34 ? 369 THR B CA 1 ATOM 1910 C C . THR B 1 45 ? 116.018 -42.759 66.914 1.00 58.38 ? 369 THR B C 1 ATOM 1911 O O . THR B 1 45 ? 115.864 -43.853 66.374 1.00 57.59 ? 369 THR B O 1 ATOM 1912 C CB . THR B 1 45 ? 115.500 -44.060 68.931 1.00 61.95 ? 369 THR B CB 1 ATOM 1913 O OG1 . THR B 1 45 ? 115.503 -44.117 70.366 1.00 62.07 ? 369 THR B OG1 1 ATOM 1914 C CG2 . THR B 1 45 ? 116.440 -45.133 68.362 1.00 62.20 ? 369 THR B CG2 1 ATOM 1915 N N . VAL B 1 46 ? 116.266 -41.651 66.218 1.00 55.90 ? 370 VAL B N 1 ATOM 1916 C CA . VAL B 1 46 ? 116.546 -41.729 64.777 1.00 53.61 ? 370 VAL B CA 1 ATOM 1917 C C . VAL B 1 46 ? 118.004 -42.034 64.507 1.00 51.37 ? 370 VAL B C 1 ATOM 1918 O O . VAL B 1 46 ? 118.773 -41.125 64.229 1.00 52.52 ? 370 VAL B O 1 ATOM 1919 C CB . VAL B 1 46 ? 116.251 -40.427 64.033 1.00 53.06 ? 370 VAL B CB 1 ATOM 1920 C CG1 . VAL B 1 46 ? 116.473 -40.642 62.539 1.00 51.83 ? 370 VAL B CG1 1 ATOM 1921 C CG2 . VAL B 1 46 ? 114.836 -39.962 64.338 1.00 53.25 ? 370 VAL B CG2 1 ATOM 1922 N N . GLN B 1 47 ? 118.375 -43.309 64.576 1.00 49.10 ? 371 GLN B N 1 ATOM 1923 C CA . GLN B 1 47 ? 119.773 -43.727 64.434 1.00 47.19 ? 371 GLN B CA 1 ATOM 1924 C C . GLN B 1 47 ? 120.396 -43.428 63.048 1.00 42.75 ? 371 GLN B C 1 ATOM 1925 O O . GLN B 1 47 ? 119.790 -43.640 61.997 1.00 39.64 ? 371 GLN B O 1 ATOM 1926 C CB . GLN B 1 47 ? 119.878 -45.210 64.801 1.00 49.22 ? 371 GLN B CB 1 ATOM 1927 C CG . GLN B 1 47 ? 121.269 -45.701 65.219 1.00 51.12 ? 371 GLN B CG 1 ATOM 1928 C CD . GLN B 1 47 ? 121.277 -47.187 65.597 1.00 52.15 ? 371 GLN B CD 1 ATOM 1929 O OE1 . GLN B 1 47 ? 120.216 -47.802 65.778 1.00 52.95 ? 371 GLN B OE1 1 ATOM 1930 N NE2 . GLN B 1 47 ? 122.476 -47.768 65.709 1.00 52.06 ? 371 GLN B NE2 1 ATOM 1931 N N . LEU B 1 48 ? 121.619 -42.904 63.065 1.00 39.41 ? 372 LEU B N 1 ATOM 1932 C CA . LEU B 1 48 ? 122.323 -42.500 61.849 1.00 36.88 ? 372 LEU B CA 1 ATOM 1933 C C . LEU B 1 48 ? 123.719 -43.097 61.838 1.00 33.67 ? 372 LEU B C 1 ATOM 1934 O O . LEU B 1 48 ? 124.572 -42.673 62.598 1.00 32.39 ? 372 LEU B O 1 ATOM 1935 C CB . LEU B 1 48 ? 122.443 -40.985 61.809 1.00 37.61 ? 372 LEU B CB 1 ATOM 1936 C CG . LEU B 1 48 ? 122.235 -40.332 60.456 1.00 38.29 ? 372 LEU B CG 1 ATOM 1937 C CD1 . LEU B 1 48 ? 120.921 -40.816 59.912 1.00 40.32 ? 372 LEU B CD1 1 ATOM 1938 C CD2 . LEU B 1 48 ? 122.203 -38.818 60.570 1.00 38.34 ? 372 LEU B CD2 1 ATOM 1939 N N . THR B 1 49 ? 123.947 -44.082 60.979 1.00 31.36 ? 373 THR B N 1 ATOM 1940 C CA . THR B 1 49 ? 125.172 -44.845 61.025 1.00 30.75 ? 373 THR B CA 1 ATOM 1941 C C . THR B 1 49 ? 125.985 -44.682 59.746 1.00 31.01 ? 373 THR B C 1 ATOM 1942 O O . THR B 1 49 ? 125.491 -44.863 58.620 1.00 29.64 ? 373 THR B O 1 ATOM 1943 C CB . THR B 1 49 ? 124.886 -46.334 61.235 1.00 31.42 ? 373 THR B CB 1 ATOM 1944 O OG1 . THR B 1 49 ? 124.019 -46.490 62.367 1.00 32.90 ? 373 THR B OG1 1 ATOM 1945 C CG2 . THR B 1 49 ? 126.185 -47.109 61.471 1.00 30.97 ? 373 THR B CG2 1 ATOM 1946 N N . TRP B 1 50 ? 127.254 -44.349 59.945 1.00 29.94 ? 374 TRP B N 1 ATOM 1947 C CA . TRP B 1 50 ? 128.139 -44.104 58.835 1.00 29.62 ? 374 TRP B CA 1 ATOM 1948 C C . TRP B 1 50 ? 128.993 -45.326 58.565 1.00 29.32 ? 374 TRP B C 1 ATOM 1949 O O . TRP B 1 50 ? 129.329 -46.081 59.477 1.00 31.59 ? 374 TRP B O 1 ATOM 1950 C CB . TRP B 1 50 ? 129.045 -42.920 59.141 1.00 30.33 ? 374 TRP B CB 1 ATOM 1951 C CG . TRP B 1 50 ? 128.388 -41.585 59.114 1.00 29.55 ? 374 TRP B CG 1 ATOM 1952 C CD1 . TRP B 1 50 ? 128.001 -40.839 60.194 1.00 30.47 ? 374 TRP B CD1 1 ATOM 1953 C CD2 . TRP B 1 50 ? 128.062 -40.809 57.954 1.00 29.16 ? 374 TRP B CD2 1 ATOM 1954 N NE1 . TRP B 1 50 ? 127.456 -39.638 59.765 1.00 29.95 ? 374 TRP B NE1 1 ATOM 1955 C CE2 . TRP B 1 50 ? 127.484 -39.603 58.398 1.00 28.03 ? 374 TRP B CE2 1 ATOM 1956 C CE3 . TRP B 1 50 ? 128.199 -41.019 56.584 1.00 30.90 ? 374 TRP B CE3 1 ATOM 1957 C CZ2 . TRP B 1 50 ? 127.034 -38.626 57.527 1.00 28.93 ? 374 TRP B CZ2 1 ATOM 1958 C CZ3 . TRP B 1 50 ? 127.763 -40.036 55.711 1.00 30.30 ? 374 TRP B CZ3 1 ATOM 1959 C CH2 . TRP B 1 50 ? 127.188 -38.852 56.189 1.00 29.72 ? 374 TRP B CH2 1 ATOM 1960 N N . SER B 1 51 ? 129.342 -45.528 57.300 1.00 27.29 ? 375 SER B N 1 ATOM 1961 C CA . SER B 1 51 ? 130.382 -46.495 56.977 1.00 27.18 ? 375 SER B CA 1 ATOM 1962 C C . SER B 1 51 ? 131.029 -46.258 55.608 1.00 25.69 ? 375 SER B C 1 ATOM 1963 O O . SER B 1 51 ? 130.580 -45.434 54.816 1.00 21.71 ? 375 SER B O 1 ATOM 1964 C CB . SER B 1 51 ? 129.821 -47.918 57.024 1.00 26.43 ? 375 SER B CB 1 ATOM 1965 O OG . SER B 1 51 ? 128.720 -48.042 56.140 1.00 26.58 ? 375 SER B OG 1 ATOM 1966 N N . ARG B 1 52 ? 132.065 -47.040 55.323 1.00 24.02 ? 376 ARG B N 1 ATOM 1967 C CA . ARG B 1 52 ? 132.696 -46.974 54.025 1.00 23.21 ? 376 ARG B CA 1 ATOM 1968 C C . ARG B 1 52 ? 132.437 -48.220 53.199 1.00 20.71 ? 376 ARG B C 1 ATOM 1969 O O . ARG B 1 52 ? 132.369 -49.306 53.744 1.00 20.21 ? 376 ARG B O 1 ATOM 1970 C CB . ARG B 1 52 ? 134.197 -46.770 54.210 1.00 22.77 ? 376 ARG B CB 1 ATOM 1971 C CG . ARG B 1 52 ? 134.538 -45.355 54.572 1.00 23.29 ? 376 ARG B CG 1 ATOM 1972 C CD . ARG B 1 52 ? 135.927 -45.048 54.005 1.00 24.29 ? 376 ARG B CD 1 ATOM 1973 N NE . ARG B 1 52 ? 136.894 -45.015 55.067 1.00 24.46 ? 376 ARG B NE 1 ATOM 1974 C CZ . ARG B 1 52 ? 138.199 -45.057 54.889 1.00 23.91 ? 376 ARG B CZ 1 ATOM 1975 N NH1 . ARG B 1 52 ? 138.725 -45.161 53.673 1.00 22.22 ? 376 ARG B NH1 1 ATOM 1976 N NH2 . ARG B 1 52 ? 138.956 -45.008 55.973 1.00 23.71 ? 376 ARG B NH2 1 ATOM 1977 N N . ALA B 1 53 ? 132.343 -48.066 51.882 1.00 18.57 ? 377 ALA B N 1 ATOM 1978 C CA . ALA B 1 53 ? 132.112 -49.225 51.016 1.00 20.80 ? 377 ALA B CA 1 ATOM 1979 C C . ALA B 1 53 ? 133.297 -50.168 51.013 1.00 20.77 ? 377 ALA B C 1 ATOM 1980 O O . ALA B 1 53 ? 133.150 -51.346 50.712 1.00 21.61 ? 377 ALA B O 1 ATOM 1981 C CB . ALA B 1 53 ? 131.797 -48.795 49.575 1.00 18.39 ? 377 ALA B CB 1 ATOM 1982 N N . SER B 1 54 ? 134.478 -49.640 51.305 1.00 21.24 ? 378 SER B N 1 ATOM 1983 C CA . SER B 1 54 ? 135.664 -50.484 51.388 1.00 21.40 ? 378 SER B CA 1 ATOM 1984 C C . SER B 1 54 ? 135.718 -51.273 52.688 1.00 20.68 ? 378 SER B C 1 ATOM 1985 O O . SER B 1 54 ? 136.430 -52.253 52.759 1.00 20.55 ? 378 SER B O 1 ATOM 1986 C CB . SER B 1 54 ? 136.923 -49.635 51.272 1.00 21.02 ? 378 SER B CB 1 ATOM 1987 O OG . SER B 1 54 ? 136.997 -48.738 52.357 1.00 21.05 ? 378 SER B OG 1 ATOM 1988 N N . GLY B 1 55 ? 134.975 -50.860 53.712 1.00 20.76 ? 379 GLY B N 1 ATOM 1989 C CA . GLY B 1 55 ? 135.048 -51.537 55.013 1.00 22.01 ? 379 GLY B CA 1 ATOM 1990 C C . GLY B 1 55 ? 136.037 -50.905 55.993 1.00 23.12 ? 379 GLY B C 1 ATOM 1991 O O . GLY B 1 55 ? 136.089 -51.248 57.168 1.00 22.41 ? 379 GLY B O 1 ATOM 1992 N N . LYS B 1 56 ? 136.833 -49.969 55.505 1.00 24.37 ? 380 LYS B N 1 ATOM 1993 C CA . LYS B 1 56 ? 137.760 -49.253 56.343 1.00 26.35 ? 380 LYS B CA 1 ATOM 1994 C C . LYS B 1 56 ? 137.027 -48.307 57.286 1.00 25.69 ? 380 LYS B C 1 ATOM 1995 O O . LYS B 1 56 ? 135.883 -47.962 57.039 1.00 24.92 ? 380 LYS B O 1 ATOM 1996 C CB . LYS B 1 56 ? 138.745 -48.484 55.459 1.00 27.75 ? 380 LYS B CB 1 ATOM 1997 C CG . LYS B 1 56 ? 139.646 -49.422 54.693 1.00 27.56 ? 380 LYS B CG 1 ATOM 1998 C CD . LYS B 1 56 ? 140.512 -48.672 53.716 1.00 28.06 ? 380 LYS B CD 1 ATOM 1999 C CE . LYS B 1 56 ? 141.292 -49.652 52.841 1.00 28.74 ? 380 LYS B CE 1 ATOM 2000 N NZ . LYS B 1 56 ? 142.191 -48.893 51.952 1.00 29.18 ? 380 LYS B NZ 1 ATOM 2001 N N . PRO B 1 57 ? 137.696 -47.884 58.367 1.00 26.52 ? 381 PRO B N 1 ATOM 2002 C CA . PRO B 1 57 ? 137.034 -47.199 59.473 1.00 27.50 ? 381 PRO B CA 1 ATOM 2003 C C . PRO B 1 57 ? 136.641 -45.786 59.127 1.00 26.51 ? 381 PRO B C 1 ATOM 2004 O O . PRO B 1 57 ? 137.324 -45.140 58.357 1.00 24.21 ? 381 PRO B O 1 ATOM 2005 C CB . PRO B 1 57 ? 138.099 -47.177 60.584 1.00 29.34 ? 381 PRO B CB 1 ATOM 2006 C CG . PRO B 1 57 ? 139.300 -47.939 60.044 1.00 29.70 ? 381 PRO B CG 1 ATOM 2007 C CD . PRO B 1 57 ? 139.155 -47.955 58.559 1.00 28.33 ? 381 PRO B CD 1 ATOM 2008 N N . VAL B 1 58 ? 135.532 -45.327 59.698 1.00 29.92 ? 382 VAL B N 1 ATOM 2009 C CA . VAL B 1 58 ? 135.061 -43.947 59.566 1.00 30.28 ? 382 VAL B CA 1 ATOM 2010 C C . VAL B 1 58 ? 135.412 -43.177 60.819 1.00 31.13 ? 382 VAL B C 1 ATOM 2011 O O . VAL B 1 58 ? 135.490 -43.756 61.905 1.00 29.51 ? 382 VAL B O 1 ATOM 2012 C CB . VAL B 1 58 ? 133.531 -43.892 59.435 1.00 31.59 ? 382 VAL B CB 1 ATOM 2013 C CG1 . VAL B 1 58 ? 133.081 -44.642 58.172 1.00 31.37 ? 382 VAL B CG1 1 ATOM 2014 C CG2 . VAL B 1 58 ? 132.861 -44.489 60.708 1.00 29.31 ? 382 VAL B CG2 1 ATOM 2015 N N . GLN B 1 59 ? 135.580 -41.865 60.665 1.00 33.15 ? 383 GLN B N 1 ATOM 2016 C CA . GLN B 1 59 ? 135.846 -40.972 61.796 1.00 34.10 ? 383 GLN B CA 1 ATOM 2017 C C . GLN B 1 59 ? 134.601 -40.671 62.621 1.00 33.55 ? 383 GLN B C 1 ATOM 2018 O O . GLN B 1 59 ? 133.489 -41.073 62.279 1.00 29.30 ? 383 GLN B O 1 ATOM 2019 C CB . GLN B 1 59 ? 136.466 -39.671 61.285 1.00 36.58 ? 383 GLN B CB 1 ATOM 2020 C CG . GLN B 1 59 ? 137.759 -39.925 60.508 1.00 39.75 ? 383 GLN B CG 1 ATOM 2021 C CD . GLN B 1 59 ? 138.447 -38.667 60.004 1.00 42.50 ? 383 GLN B CD 1 ATOM 2022 O OE1 . GLN B 1 59 ? 138.331 -37.583 60.588 1.00 43.64 ? 383 GLN B OE1 1 ATOM 2023 N NE2 . GLN B 1 59 ? 139.184 -38.813 58.907 1.00 44.52 ? 383 GLN B NE2 1 ATOM 2024 N N . HIS B 1 60 ? 134.801 -39.953 63.723 1.00 35.46 ? 384 HIS B N 1 ATOM 2025 C CA . HIS B 1 60 ? 133.692 -39.500 64.560 1.00 35.24 ? 384 HIS B CA 1 ATOM 2026 C C . HIS B 1 60 ? 132.890 -38.490 63.775 1.00 34.64 ? 384 HIS B C 1 ATOM 2027 O O . HIS B 1 60 ? 133.464 -37.660 63.066 1.00 35.60 ? 384 HIS B O 1 ATOM 2028 C CB . HIS B 1 60 ? 134.191 -38.874 65.866 1.00 37.11 ? 384 HIS B CB 1 ATOM 2029 C CG . HIS B 1 60 ? 134.857 -39.854 66.792 1.00 38.56 ? 384 HIS B CG 1 ATOM 2030 N ND1 . HIS B 1 60 ? 134.261 -41.039 67.173 1.00 39.09 ? 384 HIS B ND1 1 ATOM 2031 C CD2 . HIS B 1 60 ? 136.063 -39.825 67.412 1.00 38.93 ? 384 HIS B CD2 1 ATOM 2032 C CE1 . HIS B 1 60 ? 135.070 -41.701 67.979 1.00 39.39 ? 384 HIS B CE1 1 ATOM 2033 N NE2 . HIS B 1 60 ? 136.171 -40.986 68.141 1.00 39.65 ? 384 HIS B NE2 1 ATOM 2034 N N . SER B 1 61 ? 131.568 -38.570 63.891 1.00 33.58 ? 385 SER B N 1 ATOM 2035 C CA . SER B 1 61 ? 130.686 -37.607 63.241 1.00 34.98 ? 385 SER B CA 1 ATOM 2036 C C . SER B 1 61 ? 129.914 -36.722 64.223 1.00 36.34 ? 385 SER B C 1 ATOM 2037 O O . SER B 1 61 ? 129.683 -37.110 65.368 1.00 37.24 ? 385 SER B O 1 ATOM 2038 C CB . SER B 1 61 ? 129.691 -38.336 62.351 1.00 34.59 ? 385 SER B CB 1 ATOM 2039 O OG . SER B 1 61 ? 129.014 -39.327 63.090 1.00 34.32 ? 385 SER B OG 1 ATOM 2040 N N . THR B 1 62 ? 129.508 -35.541 63.775 1.00 35.39 ? 386 THR B N 1 ATOM 2041 C CA . THR B 1 62 ? 128.709 -34.660 64.608 1.00 37.74 ? 386 THR B CA 1 ATOM 2042 C C . THR B 1 62 ? 127.226 -34.864 64.325 1.00 39.89 ? 386 THR B C 1 ATOM 2043 O O . THR B 1 62 ? 126.858 -35.220 63.210 1.00 41.45 ? 386 THR B O 1 ATOM 2044 C CB . THR B 1 62 ? 129.019 -33.193 64.311 1.00 38.28 ? 386 THR B CB 1 ATOM 2045 O OG1 . THR B 1 62 ? 128.780 -32.951 62.930 1.00 39.43 ? 386 THR B OG1 1 ATOM 2046 C CG2 . THR B 1 62 ? 130.469 -32.869 64.604 1.00 40.27 ? 386 THR B CG2 1 ATOM 2047 N N . ARG B 1 63 ? 126.377 -34.627 65.325 1.00 40.42 ? 387 ARG B N 1 ATOM 2048 C CA . ARG B 1 63 ? 124.937 -34.807 65.176 1.00 40.58 ? 387 ARG B CA 1 ATOM 2049 C C . ARG B 1 63 ? 124.131 -33.578 65.563 1.00 41.61 ? 387 ARG B C 1 ATOM 2050 O O . ARG B 1 63 ? 124.400 -32.940 66.568 1.00 39.87 ? 387 ARG B O 1 ATOM 2051 C CB . ARG B 1 63 ? 124.457 -35.965 66.049 1.00 40.06 ? 387 ARG B CB 1 ATOM 2052 C CG . ARG B 1 63 ? 123.043 -36.408 65.735 1.00 39.58 ? 387 ARG B CG 1 ATOM 2053 C CD . ARG B 1 63 ? 122.620 -37.492 66.677 1.00 40.30 ? 387 ARG B CD 1 ATOM 2054 N NE . ARG B 1 63 ? 121.175 -37.666 66.687 1.00 41.43 ? 387 ARG B NE 1 ATOM 2055 C CZ . ARG B 1 63 ? 120.535 -38.649 66.062 1.00 42.43 ? 387 ARG B CZ 1 ATOM 2056 N NH1 . ARG B 1 63 ? 121.222 -39.543 65.363 1.00 43.16 ? 387 ARG B NH1 1 ATOM 2057 N NH2 . ARG B 1 63 ? 119.211 -38.739 66.131 1.00 42.31 ? 387 ARG B NH2 1 ATOM 2058 N N . LYS B 1 64 ? 123.102 -33.276 64.784 1.00 43.63 ? 388 LYS B N 1 ATOM 2059 C CA . LYS B 1 64 ? 122.362 -32.035 64.983 1.00 45.79 ? 388 LYS B CA 1 ATOM 2060 C C . LYS B 1 64 ? 120.873 -32.228 64.650 1.00 46.06 ? 388 LYS B C 1 ATOM 2061 O O . LYS B 1 64 ? 120.480 -32.290 63.485 1.00 45.48 ? 388 LYS B O 1 ATOM 2062 C CB . LYS B 1 64 ? 123.029 -30.941 64.131 1.00 47.31 ? 388 LYS B CB 1 ATOM 2063 C CG . LYS B 1 64 ? 122.263 -29.644 63.933 1.00 48.62 ? 388 LYS B CG 1 ATOM 2064 C CD . LYS B 1 64 ? 122.325 -28.758 65.160 1.00 50.15 ? 388 LYS B CD 1 ATOM 2065 C CE . LYS B 1 64 ? 121.848 -27.332 64.862 1.00 50.57 ? 388 LYS B CE 1 ATOM 2066 N NZ . LYS B 1 64 ? 120.470 -27.277 64.302 1.00 50.28 ? 388 LYS B NZ 1 ATOM 2067 N N . GLU B 1 65 ? 120.037 -32.335 65.675 1.00 46.92 ? 389 GLU B N 1 ATOM 2068 C CA . GLU B 1 65 ? 118.613 -32.514 65.427 1.00 48.43 ? 389 GLU B CA 1 ATOM 2069 C C . GLU B 1 65 ? 117.825 -31.268 65.808 1.00 48.82 ? 389 GLU B C 1 ATOM 2070 O O . GLU B 1 65 ? 117.925 -30.782 66.930 1.00 48.74 ? 389 GLU B O 1 ATOM 2071 C CB . GLU B 1 65 ? 118.063 -33.785 66.093 1.00 48.99 ? 389 GLU B CB 1 ATOM 2072 C CG . GLU B 1 65 ? 118.371 -33.992 67.563 1.00 49.47 ? 389 GLU B CG 1 ATOM 2073 C CD . GLU B 1 65 ? 118.078 -35.423 68.021 1.00 49.65 ? 389 GLU B CD 1 ATOM 2074 O OE1 . GLU B 1 65 ? 118.421 -36.367 67.279 1.00 48.74 ? 389 GLU B OE1 1 ATOM 2075 O OE2 . GLU B 1 65 ? 117.515 -35.610 69.126 1.00 50.15 ? 389 GLU B OE2 1 ATOM 2076 N N . GLU B 1 66 ? 117.052 -30.754 64.856 1.00 49.73 ? 390 GLU B N 1 ATOM 2077 C CA . GLU B 1 66 ? 116.390 -29.476 65.018 1.00 51.78 ? 390 GLU B CA 1 ATOM 2078 C C . GLU B 1 66 ? 114.926 -29.564 64.616 1.00 53.41 ? 390 GLU B C 1 ATOM 2079 O O . GLU B 1 66 ? 114.608 -29.915 63.479 1.00 52.52 ? 390 GLU B O 1 ATOM 2080 C CB . GLU B 1 66 ? 117.098 -28.410 64.184 1.00 52.74 ? 390 GLU B CB 1 ATOM 2081 C CG . GLU B 1 66 ? 116.399 -27.055 64.141 1.00 53.59 ? 390 GLU B CG 1 ATOM 2082 C CD . GLU B 1 66 ? 117.283 -25.951 63.561 1.00 54.85 ? 390 GLU B CD 1 ATOM 2083 O OE1 . GLU B 1 66 ? 118.371 -26.274 63.034 1.00 54.91 ? 390 GLU B OE1 1 ATOM 2084 O OE2 . GLU B 1 66 ? 116.900 -24.756 63.630 1.00 55.80 ? 390 GLU B OE2 1 ATOM 2085 N N . LYS B 1 67 ? 114.044 -29.247 65.564 1.00 55.60 ? 391 LYS B N 1 ATOM 2086 C CA . LYS B 1 67 ? 112.618 -29.108 65.283 1.00 57.14 ? 391 LYS B CA 1 ATOM 2087 C C . LYS B 1 67 ? 112.467 -27.845 64.464 1.00 58.04 ? 391 LYS B C 1 ATOM 2088 O O . LYS B 1 67 ? 112.899 -26.776 64.890 1.00 58.13 ? 391 LYS B O 1 ATOM 2089 C CB . LYS B 1 67 ? 111.798 -28.973 66.573 1.00 57.64 ? 391 LYS B CB 1 ATOM 2090 C CG . LYS B 1 67 ? 111.303 -30.280 67.201 1.00 58.04 ? 391 LYS B CG 1 ATOM 2091 C CD . LYS B 1 67 ? 110.423 -29.999 68.431 1.00 59.14 ? 391 LYS B CD 1 ATOM 2092 C CE . LYS B 1 67 ? 109.578 -31.197 68.877 1.00 59.36 ? 391 LYS B CE 1 ATOM 2093 N NZ . LYS B 1 67 ? 110.378 -32.332 69.418 1.00 59.67 ? 391 LYS B NZ 1 ATOM 2094 N N . GLN B 1 68 ? 111.875 -27.967 63.283 1.00 59.68 ? 392 GLN B N 1 ATOM 2095 C CA . GLN B 1 68 ? 111.613 -26.797 62.457 1.00 61.74 ? 392 GLN B CA 1 ATOM 2096 C C . GLN B 1 68 ? 110.113 -26.503 62.526 1.00 62.96 ? 392 GLN B C 1 ATOM 2097 O O . GLN B 1 68 ? 109.304 -27.418 62.695 1.00 63.44 ? 392 GLN B O 1 ATOM 2098 C CB . GLN B 1 68 ? 112.101 -27.014 61.020 1.00 62.75 ? 392 GLN B CB 1 ATOM 2099 C CG . GLN B 1 68 ? 113.582 -27.415 60.917 1.00 63.71 ? 392 GLN B CG 1 ATOM 2100 C CD . GLN B 1 68 ? 114.297 -26.779 59.733 1.00 64.91 ? 392 GLN B CD 1 ATOM 2101 O OE1 . GLN B 1 68 ? 113.704 -26.008 58.981 1.00 65.99 ? 392 GLN B OE1 1 ATOM 2102 N NE2 . GLN B 1 68 ? 115.580 -27.095 59.565 1.00 65.92 ? 392 GLN B NE2 1 ATOM 2103 N N . ARG B 1 69 ? 109.736 -25.231 62.421 1.00 63.44 ? 393 ARG B N 1 ATOM 2104 C CA . ARG B 1 69 ? 108.377 -24.822 62.780 1.00 63.83 ? 393 ARG B CA 1 ATOM 2105 C C . ARG B 1 69 ? 107.344 -25.149 61.696 1.00 63.07 ? 393 ARG B C 1 ATOM 2106 O O . ARG B 1 69 ? 106.338 -24.450 61.570 1.00 62.19 ? 393 ARG B O 1 ATOM 2107 C CB . ARG B 1 69 ? 108.325 -23.332 63.155 1.00 64.71 ? 393 ARG B CB 1 ATOM 2108 C CG . ARG B 1 69 ? 108.689 -22.369 62.027 1.00 65.45 ? 393 ARG B CG 1 ATOM 2109 C CD . ARG B 1 69 ? 108.075 -20.982 62.220 1.00 65.92 ? 393 ARG B CD 1 ATOM 2110 N NE . ARG B 1 69 ? 108.236 -20.169 61.015 1.00 66.53 ? 393 ARG B NE 1 ATOM 2111 C CZ . ARG B 1 69 ? 107.679 -18.976 60.820 1.00 67.36 ? 393 ARG B CZ 1 ATOM 2112 N NH1 . ARG B 1 69 ? 106.910 -18.430 61.756 1.00 67.69 ? 393 ARG B NH1 1 ATOM 2113 N NH2 . ARG B 1 69 ? 107.892 -18.325 59.680 1.00 67.30 ? 393 ARG B NH2 1 ATOM 2114 N N . ASN B 1 70 ? 107.588 -26.207 60.922 1.00 62.21 ? 394 ASN B N 1 ATOM 2115 C CA . ASN B 1 70 ? 106.572 -26.740 60.009 1.00 61.27 ? 394 ASN B CA 1 ATOM 2116 C C . ASN B 1 70 ? 105.959 -28.055 60.511 1.00 59.50 ? 394 ASN B C 1 ATOM 2117 O O . ASN B 1 70 ? 105.230 -28.722 59.776 1.00 58.29 ? 394 ASN B O 1 ATOM 2118 C CB . ASN B 1 70 ? 107.134 -26.901 58.588 1.00 62.02 ? 394 ASN B CB 1 ATOM 2119 C CG . ASN B 1 70 ? 107.837 -28.234 58.372 1.00 62.60 ? 394 ASN B CG 1 ATOM 2120 O OD1 . ASN B 1 70 ? 108.595 -28.696 59.224 1.00 63.48 ? 394 ASN B OD1 1 ATOM 2121 N ND2 . ASN B 1 70 ? 107.595 -28.852 57.220 1.00 62.62 ? 394 ASN B ND2 1 ATOM 2122 N N . GLY B 1 71 ? 106.251 -28.410 61.764 1.00 58.19 ? 395 GLY B N 1 ATOM 2123 C CA . GLY B 1 71 ? 105.677 -29.594 62.422 1.00 56.69 ? 395 GLY B CA 1 ATOM 2124 C C . GLY B 1 71 ? 106.548 -30.843 62.377 1.00 55.35 ? 395 GLY B C 1 ATOM 2125 O O . GLY B 1 71 ? 106.182 -31.888 62.915 1.00 54.78 ? 395 GLY B O 1 ATOM 2126 N N . THR B 1 72 ? 107.710 -30.728 61.737 1.00 53.71 ? 396 THR B N 1 ATOM 2127 C CA . THR B 1 72 ? 108.551 -31.876 61.430 1.00 51.97 ? 396 THR B CA 1 ATOM 2128 C C . THR B 1 72 ? 109.943 -31.751 62.045 1.00 50.07 ? 396 THR B C 1 ATOM 2129 O O . THR B 1 72 ? 110.404 -30.660 62.397 1.00 49.90 ? 396 THR B O 1 ATOM 2130 C CB . THR B 1 72 ? 108.722 -32.050 59.907 1.00 52.20 ? 396 THR B CB 1 ATOM 2131 O OG1 . THR B 1 72 ? 108.276 -33.356 59.514 1.00 52.99 ? 396 THR B OG1 1 ATOM 2132 C CG2 . THR B 1 72 ? 110.179 -31.844 59.495 1.00 51.09 ? 396 THR B CG2 1 ATOM 2133 N N . LEU B 1 73 ? 110.607 -32.894 62.164 1.00 47.36 ? 397 LEU B N 1 ATOM 2134 C CA . LEU B 1 73 ? 111.956 -32.928 62.695 1.00 45.81 ? 397 LEU B CA 1 ATOM 2135 C C . LEU B 1 73 ? 113.003 -33.202 61.620 1.00 42.71 ? 397 LEU B C 1 ATOM 2136 O O . LEU B 1 73 ? 112.788 -33.967 60.684 1.00 40.63 ? 397 LEU B O 1 ATOM 2137 C CB . LEU B 1 73 ? 112.094 -33.974 63.799 1.00 46.45 ? 397 LEU B CB 1 ATOM 2138 C CG . LEU B 1 73 ? 113.438 -33.837 64.523 1.00 46.93 ? 397 LEU B CG 1 ATOM 2139 C CD1 . LEU B 1 73 ? 113.524 -32.454 65.176 1.00 46.82 ? 397 LEU B CD1 1 ATOM 2140 C CD2 . LEU B 1 73 ? 113.639 -34.950 65.550 1.00 46.99 ? 397 LEU B CD2 1 ATOM 2141 N N . THR B 1 74 ? 114.146 -32.557 61.802 1.00 39.83 ? 398 THR B N 1 ATOM 2142 C CA . THR B 1 74 ? 115.259 -32.653 60.890 1.00 38.43 ? 398 THR B CA 1 ATOM 2143 C C . THR B 1 74 ? 116.469 -33.157 61.678 1.00 38.08 ? 398 THR B C 1 ATOM 2144 O O . THR B 1 74 ? 116.715 -32.757 62.818 1.00 37.65 ? 398 THR B O 1 ATOM 2145 C CB . THR B 1 74 ? 115.524 -31.287 60.237 1.00 37.68 ? 398 THR B CB 1 ATOM 2146 O OG1 . THR B 1 74 ? 114.982 -31.287 58.908 1.00 37.51 ? 398 THR B OG1 1 ATOM 2147 C CG2 . THR B 1 74 ? 116.994 -30.975 60.183 1.00 38.95 ? 398 THR B CG2 1 ATOM 2148 N N . VAL B 1 75 ? 117.216 -34.075 61.085 1.00 36.79 ? 399 VAL B N 1 ATOM 2149 C CA . VAL B 1 75 ? 118.429 -34.539 61.727 1.00 36.04 ? 399 VAL B CA 1 ATOM 2150 C C . VAL B 1 75 ? 119.535 -34.604 60.690 1.00 35.49 ? 399 VAL B C 1 ATOM 2151 O O . VAL B 1 75 ? 119.347 -35.154 59.598 1.00 33.84 ? 399 VAL B O 1 ATOM 2152 C CB . VAL B 1 75 ? 118.220 -35.855 62.497 1.00 36.49 ? 399 VAL B CB 1 ATOM 2153 C CG1 . VAL B 1 75 ? 117.189 -36.705 61.804 1.00 38.28 ? 399 VAL B CG1 1 ATOM 2154 C CG2 . VAL B 1 75 ? 119.542 -36.598 62.715 1.00 36.05 ? 399 VAL B CG2 1 ATOM 2155 N N . THR B 1 76 ? 120.663 -33.981 61.037 1.00 34.97 ? 400 THR B N 1 ATOM 2156 C CA . THR B 1 76 ? 121.806 -33.846 60.142 1.00 36.47 ? 400 THR B CA 1 ATOM 2157 C C . THR B 1 76 ? 123.025 -34.343 60.883 1.00 36.89 ? 400 THR B C 1 ATOM 2158 O O . THR B 1 76 ? 123.189 -34.078 62.071 1.00 39.89 ? 400 THR B O 1 ATOM 2159 C CB . THR B 1 76 ? 122.058 -32.381 59.652 1.00 36.07 ? 400 THR B CB 1 ATOM 2160 O OG1 . THR B 1 76 ? 122.282 -31.522 60.775 1.00 37.53 ? 400 THR B OG1 1 ATOM 2161 C CG2 . THR B 1 76 ? 120.871 -31.846 58.882 1.00 35.84 ? 400 THR B CG2 1 ATOM 2162 N N . SER B 1 77 ? 123.873 -35.074 60.172 1.00 36.78 ? 401 SER B N 1 ATOM 2163 C CA . SER B 1 77 ? 125.113 -35.591 60.727 1.00 35.49 ? 401 SER B CA 1 ATOM 2164 C C . SER B 1 77 ? 126.191 -35.323 59.695 1.00 35.09 ? 401 SER B C 1 ATOM 2165 O O . SER B 1 77 ? 125.968 -35.549 58.510 1.00 35.76 ? 401 SER B O 1 ATOM 2166 C CB . SER B 1 77 ? 124.985 -37.095 60.972 1.00 35.34 ? 401 SER B CB 1 ATOM 2167 O OG . SER B 1 77 ? 126.217 -37.654 61.369 1.00 34.77 ? 401 SER B OG 1 ATOM 2168 N N . THR B 1 78 ? 127.342 -34.821 60.127 1.00 35.42 ? 402 THR B N 1 ATOM 2169 C CA . THR B 1 78 ? 128.410 -34.493 59.192 1.00 33.80 ? 402 THR B CA 1 ATOM 2170 C C . THR B 1 78 ? 129.610 -35.330 59.550 1.00 30.81 ? 402 THR B C 1 ATOM 2171 O O . THR B 1 78 ? 129.946 -35.452 60.727 1.00 30.64 ? 402 THR B O 1 ATOM 2172 C CB . THR B 1 78 ? 128.757 -32.997 59.175 1.00 34.15 ? 402 THR B CB 1 ATOM 2173 O OG1 . THR B 1 78 ? 127.635 -32.303 58.650 1.00 35.06 ? 402 THR B OG1 1 ATOM 2174 C CG2 . THR B 1 78 ? 129.904 -32.680 58.221 1.00 33.83 ? 402 THR B CG2 1 ATOM 2175 N N . LEU B 1 79 ? 130.214 -35.912 58.516 1.00 27.23 ? 403 LEU B N 1 ATOM 2176 C CA . LEU B 1 79 ? 131.330 -36.834 58.664 1.00 25.27 ? 403 LEU B CA 1 ATOM 2177 C C . LEU B 1 79 ? 132.488 -36.245 57.893 1.00 26.66 ? 403 LEU B C 1 ATOM 2178 O O . LEU B 1 79 ? 132.330 -35.891 56.727 1.00 27.86 ? 403 LEU B O 1 ATOM 2179 C CB . LEU B 1 79 ? 130.990 -38.203 58.081 1.00 24.06 ? 403 LEU B CB 1 ATOM 2180 C CG . LEU B 1 79 ? 132.066 -39.291 58.211 1.00 22.77 ? 403 LEU B CG 1 ATOM 2181 C CD1 . LEU B 1 79 ? 132.266 -39.689 59.687 1.00 20.48 ? 403 LEU B CD1 1 ATOM 2182 C CD2 . LEU B 1 79 ? 131.663 -40.482 57.356 1.00 20.46 ? 403 LEU B CD2 1 ATOM 2183 N N . PRO B 1 80 ? 133.644 -36.102 58.545 1.00 27.07 ? 404 PRO B N 1 ATOM 2184 C CA . PRO B 1 80 ? 134.839 -35.716 57.821 1.00 27.32 ? 404 PRO B CA 1 ATOM 2185 C C . PRO B 1 80 ? 135.371 -36.933 57.108 1.00 28.89 ? 404 PRO B C 1 ATOM 2186 O O . PRO B 1 80 ? 135.300 -38.053 57.640 1.00 30.00 ? 404 PRO B O 1 ATOM 2187 C CB . PRO B 1 80 ? 135.820 -35.282 58.905 1.00 26.57 ? 404 PRO B CB 1 ATOM 2188 C CG . PRO B 1 80 ? 135.275 -35.796 60.192 1.00 28.08 ? 404 PRO B CG 1 ATOM 2189 C CD . PRO B 1 80 ? 133.854 -36.219 59.996 1.00 28.54 ? 404 PRO B CD 1 ATOM 2190 N N . VAL B 1 81 ? 135.874 -36.709 55.902 1.00 27.11 ? 405 VAL B N 1 ATOM 2191 C CA . VAL B 1 81 ? 136.384 -37.803 55.100 1.00 26.92 ? 405 VAL B CA 1 ATOM 2192 C C . VAL B 1 81 ? 137.828 -37.498 54.724 1.00 25.53 ? 405 VAL B C 1 ATOM 2193 O O . VAL B 1 81 ? 138.277 -36.362 54.826 1.00 21.67 ? 405 VAL B O 1 ATOM 2194 C CB . VAL B 1 81 ? 135.510 -38.013 53.825 1.00 26.92 ? 405 VAL B CB 1 ATOM 2195 C CG1 . VAL B 1 81 ? 134.112 -38.508 54.212 1.00 24.82 ? 405 VAL B CG1 1 ATOM 2196 C CG2 . VAL B 1 81 ? 135.431 -36.750 53.034 1.00 23.31 ? 405 VAL B CG2 1 ATOM 2197 N N . GLY B 1 82 ? 138.561 -38.527 54.310 1.00 26.43 ? 406 GLY B N 1 ATOM 2198 C CA . GLY B 1 82 ? 139.957 -38.345 53.924 1.00 25.84 ? 406 GLY B CA 1 ATOM 2199 C C . GLY B 1 82 ? 140.041 -37.724 52.543 1.00 25.92 ? 406 GLY B C 1 ATOM 2200 O O . GLY B 1 82 ? 139.269 -38.051 51.647 1.00 25.45 ? 406 GLY B O 1 ATOM 2201 N N . THR B 1 83 ? 140.992 -36.827 52.367 1.00 26.23 ? 407 THR B N 1 ATOM 2202 C CA . THR B 1 83 ? 141.105 -36.089 51.150 1.00 26.45 ? 407 THR B CA 1 ATOM 2203 C C . THR B 1 83 ? 141.538 -37.048 50.069 1.00 27.51 ? 407 THR B C 1 ATOM 2204 O O . THR B 1 83 ? 140.924 -37.126 49.015 1.00 29.33 ? 407 THR B O 1 ATOM 2205 C CB . THR B 1 83 ? 142.113 -34.946 51.299 1.00 26.85 ? 407 THR B CB 1 ATOM 2206 O OG1 . THR B 1 83 ? 141.594 -34.000 52.241 1.00 27.79 ? 407 THR B OG1 1 ATOM 2207 C CG2 . THR B 1 83 ? 142.324 -34.245 49.971 1.00 26.92 ? 407 THR B CG2 1 ATOM 2208 N N . ARG B 1 84 ? 142.598 -37.791 50.320 1.00 30.08 ? 408 ARG B N 1 ATOM 2209 C CA . ARG B 1 84 ? 143.042 -38.793 49.365 1.00 31.90 ? 408 ARG B CA 1 ATOM 2210 C C . ARG B 1 84 ? 141.969 -39.871 49.160 1.00 30.77 ? 408 ARG B C 1 ATOM 2211 O O . ARG B 1 84 ? 141.718 -40.308 48.033 1.00 31.02 ? 408 ARG B O 1 ATOM 2212 C CB . ARG B 1 84 ? 144.357 -39.397 49.847 1.00 35.17 ? 408 ARG B CB 1 ATOM 2213 C CG . ARG B 1 84 ? 145.293 -39.803 48.732 1.00 39.02 ? 408 ARG B CG 1 ATOM 2214 C CD . ARG B 1 84 ? 145.590 -38.611 47.785 1.00 41.15 ? 408 ARG B CD 1 ATOM 2215 N NE . ARG B 1 84 ? 145.518 -39.078 46.401 1.00 42.99 ? 408 ARG B NE 1 ATOM 2216 C CZ . ARG B 1 84 ? 145.335 -38.310 45.337 1.00 43.30 ? 408 ARG B CZ 1 ATOM 2217 N NH1 . ARG B 1 84 ? 145.212 -36.994 45.457 1.00 42.93 ? 408 ARG B NH1 1 ATOM 2218 N NH2 . ARG B 1 84 ? 145.274 -38.888 44.144 1.00 44.64 ? 408 ARG B NH2 1 ATOM 2219 N N . ASP B 1 85 ? 141.320 -40.276 50.251 1.00 30.64 ? 409 ASP B N 1 ATOM 2220 C CA . ASP B 1 85 ? 140.338 -41.366 50.228 1.00 28.58 ? 409 ASP B CA 1 ATOM 2221 C C . ASP B 1 85 ? 139.222 -41.068 49.225 1.00 27.91 ? 409 ASP B C 1 ATOM 2222 O O . ASP B 1 85 ? 138.836 -41.917 48.418 1.00 26.69 ? 409 ASP B O 1 ATOM 2223 C CB . ASP B 1 85 ? 139.717 -41.549 51.612 1.00 29.04 ? 409 ASP B CB 1 ATOM 2224 C CG . ASP B 1 85 ? 140.627 -42.276 52.580 1.00 29.26 ? 409 ASP B CG 1 ATOM 2225 O OD1 . ASP B 1 85 ? 141.491 -43.030 52.105 1.00 29.10 ? 409 ASP B OD1 1 ATOM 2226 O OD2 . ASP B 1 85 ? 140.465 -42.101 53.816 1.00 30.88 ? 409 ASP B OD2 1 ATOM 2227 N N . TRP B 1 86 ? 138.724 -39.838 49.290 1.00 26.73 ? 410 TRP B N 1 ATOM 2228 C CA . TRP B 1 86 ? 137.648 -39.360 48.420 1.00 25.54 ? 410 TRP B CA 1 ATOM 2229 C C . TRP B 1 86 ? 138.077 -39.175 46.963 1.00 26.41 ? 410 TRP B C 1 ATOM 2230 O O . TRP B 1 86 ? 137.335 -39.469 46.042 1.00 25.14 ? 410 TRP B O 1 ATOM 2231 C CB . TRP B 1 86 ? 137.113 -38.018 48.945 1.00 22.95 ? 410 TRP B CB 1 ATOM 2232 C CG . TRP B 1 86 ? 136.010 -37.553 48.092 1.00 21.96 ? 410 TRP B CG 1 ATOM 2233 C CD1 . TRP B 1 86 ? 136.116 -36.764 46.997 1.00 20.39 ? 410 TRP B CD1 1 ATOM 2234 C CD2 . TRP B 1 86 ? 134.616 -37.881 48.225 1.00 20.70 ? 410 TRP B CD2 1 ATOM 2235 N NE1 . TRP B 1 86 ? 134.871 -36.567 46.439 1.00 21.45 ? 410 TRP B NE1 1 ATOM 2236 C CE2 . TRP B 1 86 ? 133.935 -37.242 47.176 1.00 20.13 ? 410 TRP B CE2 1 ATOM 2237 C CE3 . TRP B 1 86 ? 133.882 -38.629 49.141 1.00 19.94 ? 410 TRP B CE3 1 ATOM 2238 C CZ2 . TRP B 1 86 ? 132.572 -37.355 46.997 1.00 20.83 ? 410 TRP B CZ2 1 ATOM 2239 C CZ3 . TRP B 1 86 ? 132.526 -38.725 48.974 1.00 20.36 ? 410 TRP B CZ3 1 ATOM 2240 C CH2 . TRP B 1 86 ? 131.882 -38.098 47.915 1.00 21.05 ? 410 TRP B CH2 1 ATOM 2241 N N . ILE B 1 87 ? 139.281 -38.665 46.749 1.00 29.72 ? 411 ILE B N 1 ATOM 2242 C CA . ILE B 1 87 ? 139.769 -38.421 45.397 1.00 29.76 ? 411 ILE B CA 1 ATOM 2243 C C . ILE B 1 87 ? 140.025 -39.734 44.668 1.00 29.07 ? 411 ILE B C 1 ATOM 2244 O O . ILE B 1 87 ? 139.739 -39.852 43.483 1.00 28.80 ? 411 ILE B O 1 ATOM 2245 C CB . ILE B 1 87 ? 141.062 -37.582 45.431 1.00 31.78 ? 411 ILE B CB 1 ATOM 2246 C CG1 . ILE B 1 87 ? 140.732 -36.183 45.917 1.00 31.61 ? 411 ILE B CG1 1 ATOM 2247 C CG2 . ILE B 1 87 ? 141.708 -37.448 44.026 1.00 31.13 ? 411 ILE B CG2 1 ATOM 2248 C CD1 . ILE B 1 87 ? 139.841 -35.527 44.937 1.00 35.11 ? 411 ILE B CD1 1 ATOM 2249 N N . GLU B 1 88 ? 140.556 -40.719 45.375 1.00 29.24 ? 412 GLU B N 1 ATOM 2250 C CA . GLU B 1 88 ? 140.774 -42.039 44.792 1.00 30.16 ? 412 GLU B CA 1 ATOM 2251 C C . GLU B 1 88 ? 139.501 -42.871 44.625 1.00 30.03 ? 412 GLU B C 1 ATOM 2252 O O . GLU B 1 88 ? 139.532 -43.938 44.002 1.00 31.62 ? 412 GLU B O 1 ATOM 2253 C CB . GLU B 1 88 ? 141.728 -42.824 45.668 1.00 31.95 ? 412 GLU B CB 1 ATOM 2254 C CG . GLU B 1 88 ? 143.193 -42.425 45.524 1.00 33.54 ? 412 GLU B CG 1 ATOM 2255 C CD . GLU B 1 88 ? 144.056 -43.204 46.493 1.00 35.37 ? 412 GLU B CD 1 ATOM 2256 O OE1 . GLU B 1 88 ? 143.507 -43.915 47.388 1.00 35.20 ? 412 GLU B OE1 1 ATOM 2257 O OE2 . GLU B 1 88 ? 145.285 -43.096 46.349 1.00 36.66 ? 412 GLU B OE2 1 ATOM 2258 N N . GLY B 1 89 ? 138.387 -42.407 45.184 1.00 27.26 ? 413 GLY B N 1 ATOM 2259 C CA . GLY B 1 89 ? 137.078 -42.925 44.788 1.00 26.86 ? 413 GLY B CA 1 ATOM 2260 C C . GLY B 1 89 ? 136.320 -43.741 45.826 1.00 24.92 ? 413 GLY B C 1 ATOM 2261 O O . GLY B 1 89 ? 135.517 -44.608 45.507 1.00 22.95 ? 413 GLY B O 1 ATOM 2262 N N . GLU B 1 90 ? 136.559 -43.467 47.094 1.00 24.60 ? 414 GLU B N 1 ATOM 2263 C CA . GLU B 1 90 ? 135.880 -44.207 48.151 1.00 22.28 ? 414 GLU B CA 1 ATOM 2264 C C . GLU B 1 90 ? 134.391 -43.887 48.100 1.00 20.27 ? 414 GLU B C 1 ATOM 2265 O O . GLU B 1 90 ? 133.995 -42.824 47.650 1.00 20.15 ? 414 GLU B O 1 ATOM 2266 C CB . GLU B 1 90 ? 136.483 -43.804 49.504 1.00 23.19 ? 414 GLU B CB 1 ATOM 2267 C CG . GLU B 1 90 ? 135.759 -44.386 50.752 1.00 23.92 ? 414 GLU B CG 1 ATOM 2268 C CD . GLU B 1 90 ? 135.848 -45.908 50.825 1.00 23.22 ? 414 GLU B CD 1 ATOM 2269 O OE1 . GLU B 1 90 ? 135.070 -46.589 50.109 1.00 24.61 ? 414 GLU B OE1 1 ATOM 2270 O OE2 . GLU B 1 90 ? 136.717 -46.404 51.576 1.00 22.26 ? 414 GLU B OE2 1 ATOM 2271 N N . THR B 1 91 ? 133.534 -44.790 48.546 1.00 19.71 ? 415 THR B N 1 ATOM 2272 C CA . THR B 1 91 ? 132.122 -44.420 48.578 1.00 21.65 ? 415 THR B CA 1 ATOM 2273 C C . THR B 1 91 ? 131.659 -44.492 50.030 1.00 21.66 ? 415 THR B C 1 ATOM 2274 O O . THR B 1 91 ? 131.928 -45.451 50.733 1.00 22.63 ? 415 THR B O 1 ATOM 2275 C CB . THR B 1 91 ? 131.234 -45.259 47.636 1.00 22.39 ? 415 THR B CB 1 ATOM 2276 O OG1 . THR B 1 91 ? 130.795 -46.407 48.333 1.00 28.16 ? 415 THR B OG1 1 ATOM 2277 C CG2 . THR B 1 91 ? 131.978 -45.744 46.417 1.00 22.53 ? 415 THR B CG2 1 ATOM 2278 N N . TYR B 1 92 ? 131.015 -43.432 50.496 1.00 22.35 ? 416 TYR B N 1 ATOM 2279 C CA . TYR B 1 92 ? 130.570 -43.345 51.884 1.00 21.35 ? 416 TYR B CA 1 ATOM 2280 C C . TYR B 1 92 ? 129.069 -43.568 51.965 1.00 23.71 ? 416 TYR B C 1 ATOM 2281 O O . TYR B 1 92 ? 128.303 -43.306 51.004 1.00 20.18 ? 416 TYR B O 1 ATOM 2282 C CB . TYR B 1 92 ? 130.950 -41.989 52.477 1.00 20.37 ? 416 TYR B CB 1 ATOM 2283 C CG . TYR B 1 92 ? 132.438 -41.802 52.566 1.00 18.32 ? 416 TYR B CG 1 ATOM 2284 C CD1 . TYR B 1 92 ? 133.171 -41.494 51.429 1.00 18.95 ? 416 TYR B CD1 1 ATOM 2285 C CD2 . TYR B 1 92 ? 133.118 -41.967 53.762 1.00 17.00 ? 416 TYR B CD2 1 ATOM 2286 C CE1 . TYR B 1 92 ? 134.540 -41.344 51.482 1.00 19.47 ? 416 TYR B CE1 1 ATOM 2287 C CE2 . TYR B 1 92 ? 134.501 -41.809 53.821 1.00 18.50 ? 416 TYR B CE2 1 ATOM 2288 C CZ . TYR B 1 92 ? 135.206 -41.504 52.664 1.00 19.10 ? 416 TYR B CZ 1 ATOM 2289 O OH . TYR B 1 92 ? 136.578 -41.330 52.630 1.00 20.67 ? 416 TYR B OH 1 ATOM 2290 N N . GLN B 1 93 ? 128.650 -44.103 53.103 1.00 26.78 ? 417 GLN B N 1 ATOM 2291 C CA . GLN B 1 93 ? 127.250 -44.488 53.250 1.00 30.61 ? 417 GLN B CA 1 ATOM 2292 C C . GLN B 1 93 ? 126.625 -44.193 54.622 1.00 31.64 ? 417 GLN B C 1 ATOM 2293 O O . GLN B 1 93 ? 127.254 -44.273 55.671 1.00 30.20 ? 417 GLN B O 1 ATOM 2294 C CB . GLN B 1 93 ? 127.030 -45.933 52.817 1.00 32.66 ? 417 GLN B CB 1 ATOM 2295 C CG . GLN B 1 93 ? 127.869 -46.975 53.519 1.00 35.58 ? 417 GLN B CG 1 ATOM 2296 C CD . GLN B 1 93 ? 128.205 -48.215 52.633 1.00 36.81 ? 417 GLN B CD 1 ATOM 2297 O OE1 . GLN B 1 93 ? 127.915 -48.251 51.430 1.00 37.81 ? 417 GLN B OE1 1 ATOM 2298 N NE2 . GLN B 1 93 ? 128.835 -49.217 53.242 1.00 36.07 ? 417 GLN B NE2 1 ATOM 2299 N N . CYS B 1 94 ? 125.363 -43.797 54.575 1.00 32.68 ? 418 CYS B N 1 ATOM 2300 C CA . CYS B 1 94 ? 124.657 -43.314 55.724 1.00 33.00 ? 418 CYS B CA 1 ATOM 2301 C C . CYS B 1 94 ? 123.435 -44.205 55.756 1.00 34.04 ? 418 CYS B C 1 ATOM 2302 O O . CYS B 1 94 ? 122.631 -44.180 54.832 1.00 30.41 ? 418 CYS B O 1 ATOM 2303 C CB . CYS B 1 94 ? 124.269 -41.854 55.513 1.00 34.74 ? 418 CYS B CB 1 ATOM 2304 S SG . CYS B 1 94 ? 123.140 -41.243 56.768 1.00 37.99 ? 418 CYS B SG 1 ATOM 2305 N N . ARG B 1 95 ? 123.327 -45.017 56.800 1.00 35.87 ? 419 ARG B N 1 ATOM 2306 C CA . ARG B 1 95 ? 122.146 -45.840 57.008 1.00 37.93 ? 419 ARG B CA 1 ATOM 2307 C C . ARG B 1 95 ? 121.286 -45.226 58.109 1.00 38.05 ? 419 ARG B C 1 ATOM 2308 O O . ARG B 1 95 ? 121.773 -44.957 59.205 1.00 36.10 ? 419 ARG B O 1 ATOM 2309 C CB . ARG B 1 95 ? 122.537 -47.269 57.415 1.00 39.06 ? 419 ARG B CB 1 ATOM 2310 C CG . ARG B 1 95 ? 121.699 -48.361 56.748 1.00 40.05 ? 419 ARG B CG 1 ATOM 2311 C CD . ARG B 1 95 ? 121.653 -49.678 57.547 1.00 41.29 ? 419 ARG B CD 1 ATOM 2312 N NE . ARG B 1 95 ? 120.660 -50.604 57.006 1.00 40.87 ? 419 ARG B NE 1 ATOM 2313 C CZ . ARG B 1 95 ? 120.133 -51.610 57.691 1.00 42.10 ? 419 ARG B CZ 1 ATOM 2314 N NH1 . ARG B 1 95 ? 120.505 -51.823 58.944 1.00 42.83 ? 419 ARG B NH1 1 ATOM 2315 N NH2 . ARG B 1 95 ? 119.234 -52.407 57.128 1.00 42.68 ? 419 ARG B NH2 1 ATOM 2316 N N . VAL B 1 96 ? 120.008 -45.028 57.808 1.00 40.75 ? 420 VAL B N 1 ATOM 2317 C CA . VAL B 1 96 ? 119.059 -44.447 58.754 1.00 42.92 ? 420 VAL B CA 1 ATOM 2318 C C . VAL B 1 96 ? 118.028 -45.443 59.267 1.00 45.06 ? 420 VAL B C 1 ATOM 2319 O O . VAL B 1 96 ? 117.209 -45.952 58.507 1.00 45.19 ? 420 VAL B O 1 ATOM 2320 C CB . VAL B 1 96 ? 118.265 -43.300 58.127 1.00 42.52 ? 420 VAL B CB 1 ATOM 2321 C CG1 . VAL B 1 96 ? 117.505 -42.552 59.219 1.00 42.33 ? 420 VAL B CG1 1 ATOM 2322 C CG2 . VAL B 1 96 ? 119.184 -42.384 57.358 1.00 40.48 ? 420 VAL B CG2 1 ATOM 2323 N N . THR B 1 97 ? 118.076 -45.689 60.572 1.00 48.46 ? 421 THR B N 1 ATOM 2324 C CA . THR B 1 97 ? 117.117 -46.527 61.270 1.00 50.82 ? 421 THR B CA 1 ATOM 2325 C C . THR B 1 97 ? 116.215 -45.610 62.094 1.00 55.24 ? 421 THR B C 1 ATOM 2326 O O . THR B 1 97 ? 116.713 -44.906 62.976 1.00 55.09 ? 421 THR B O 1 ATOM 2327 C CB . THR B 1 97 ? 117.865 -47.483 62.217 1.00 50.10 ? 421 THR B CB 1 ATOM 2328 O OG1 . THR B 1 97 ? 118.374 -48.587 61.466 1.00 48.93 ? 421 THR B OG1 1 ATOM 2329 C CG2 . THR B 1 97 ? 116.959 -47.996 63.332 1.00 50.36 ? 421 THR B CG2 1 ATOM 2330 N N . HIS B 1 98 ? 114.912 -45.609 61.791 1.00 60.51 ? 422 HIS B N 1 ATOM 2331 C CA . HIS B 1 98 ? 113.884 -44.890 62.577 1.00 64.40 ? 422 HIS B CA 1 ATOM 2332 C C . HIS B 1 98 ? 113.185 -45.878 63.534 1.00 66.32 ? 422 HIS B C 1 ATOM 2333 O O . HIS B 1 98 ? 113.180 -47.092 63.301 1.00 65.99 ? 422 HIS B O 1 ATOM 2334 C CB . HIS B 1 98 ? 112.880 -44.167 61.633 1.00 66.04 ? 422 HIS B CB 1 ATOM 2335 C CG . HIS B 1 98 ? 111.852 -43.298 62.320 1.00 67.62 ? 422 HIS B CG 1 ATOM 2336 N ND1 . HIS B 1 98 ? 112.144 -42.069 62.880 1.00 68.93 ? 422 HIS B ND1 1 ATOM 2337 C CD2 . HIS B 1 98 ? 110.517 -43.471 62.497 1.00 67.88 ? 422 HIS B CD2 1 ATOM 2338 C CE1 . HIS B 1 98 ? 111.045 -41.539 63.395 1.00 68.68 ? 422 HIS B CE1 1 ATOM 2339 N NE2 . HIS B 1 98 ? 110.043 -42.370 63.173 1.00 68.21 ? 422 HIS B NE2 1 ATOM 2340 N N . PRO B 1 99 ? 112.605 -45.362 64.635 1.00 68.42 ? 423 PRO B N 1 ATOM 2341 C CA . PRO B 1 99 ? 111.892 -46.239 65.562 1.00 68.91 ? 423 PRO B CA 1 ATOM 2342 C C . PRO B 1 99 ? 110.763 -47.019 64.894 1.00 70.02 ? 423 PRO B C 1 ATOM 2343 O O . PRO B 1 99 ? 110.740 -48.249 64.968 1.00 69.87 ? 423 PRO B O 1 ATOM 2344 C CB . PRO B 1 99 ? 111.330 -45.267 66.604 1.00 69.04 ? 423 PRO B CB 1 ATOM 2345 C CG . PRO B 1 99 ? 112.220 -44.069 66.543 1.00 69.01 ? 423 PRO B CG 1 ATOM 2346 C CD . PRO B 1 99 ? 112.656 -43.967 65.118 1.00 68.74 ? 423 PRO B CD 1 ATOM 2347 N N . HIS B 1 100 ? 109.837 -46.311 64.250 1.00 71.34 ? 424 HIS B N 1 ATOM 2348 C CA . HIS B 1 100 ? 108.729 -46.951 63.541 1.00 72.12 ? 424 HIS B CA 1 ATOM 2349 C C . HIS B 1 100 ? 109.085 -47.197 62.077 1.00 72.05 ? 424 HIS B C 1 ATOM 2350 O O . HIS B 1 100 ? 108.243 -47.068 61.193 1.00 71.34 ? 424 HIS B O 1 ATOM 2351 C CB . HIS B 1 100 ? 107.421 -46.145 63.674 1.00 73.29 ? 424 HIS B CB 1 ATOM 2352 C CG . HIS B 1 100 ? 107.364 -44.896 62.842 1.00 74.49 ? 424 HIS B CG 1 ATOM 2353 N ND1 . HIS B 1 100 ? 106.750 -43.741 63.281 1.00 75.29 ? 424 HIS B ND1 1 ATOM 2354 C CD2 . HIS B 1 100 ? 107.828 -44.622 61.598 1.00 75.14 ? 424 HIS B CD2 1 ATOM 2355 C CE1 . HIS B 1 100 ? 106.846 -42.809 62.349 1.00 75.68 ? 424 HIS B CE1 1 ATOM 2356 N NE2 . HIS B 1 100 ? 107.499 -43.317 61.318 1.00 75.63 ? 424 HIS B NE2 1 ATOM 2357 N N . LEU B 1 101 ? 110.341 -47.553 61.821 1.00 72.96 ? 425 LEU B N 1 ATOM 2358 C CA . LEU B 1 101 ? 110.777 -47.860 60.464 1.00 73.21 ? 425 LEU B CA 1 ATOM 2359 C C . LEU B 1 101 ? 110.252 -49.230 60.035 1.00 72.80 ? 425 LEU B C 1 ATOM 2360 O O . LEU B 1 101 ? 110.192 -50.161 60.845 1.00 72.88 ? 425 LEU B O 1 ATOM 2361 C CB . LEU B 1 101 ? 112.306 -47.846 60.364 1.00 73.73 ? 425 LEU B CB 1 ATOM 2362 C CG . LEU B 1 101 ? 113.066 -48.981 61.074 1.00 73.97 ? 425 LEU B CG 1 ATOM 2363 C CD1 . LEU B 1 101 ? 112.595 -50.389 60.679 1.00 73.71 ? 425 LEU B CD1 1 ATOM 2364 C CD2 . LEU B 1 101 ? 114.567 -48.844 60.831 1.00 73.44 ? 425 LEU B CD2 1 ATOM 2365 N N . PRO B 1 102 ? 109.860 -49.353 58.755 1.00 72.10 ? 426 PRO B N 1 ATOM 2366 C CA . PRO B 1 102 ? 109.684 -50.688 58.178 1.00 71.12 ? 426 PRO B CA 1 ATOM 2367 C C . PRO B 1 102 ? 111.049 -51.285 57.829 1.00 69.57 ? 426 PRO B C 1 ATOM 2368 O O . PRO B 1 102 ? 111.479 -52.271 58.431 1.00 69.80 ? 426 PRO B O 1 ATOM 2369 C CB . PRO B 1 102 ? 108.846 -50.434 56.914 1.00 71.43 ? 426 PRO B CB 1 ATOM 2370 C CG . PRO B 1 102 ? 108.574 -48.932 56.863 1.00 71.62 ? 426 PRO B CG 1 ATOM 2371 C CD . PRO B 1 102 ? 109.548 -48.280 57.792 1.00 71.75 ? 426 PRO B CD 1 ATOM 2372 N N . ARG B 1 103 ? 111.727 -50.665 56.870 1.00 67.51 ? 427 ARG B N 1 ATOM 2373 C CA . ARG B 1 103 ? 113.093 -51.034 56.522 1.00 66.06 ? 427 ARG B CA 1 ATOM 2374 C C . ARG B 1 103 ? 114.025 -49.869 56.843 1.00 63.89 ? 427 ARG B C 1 ATOM 2375 O O . ARG B 1 103 ? 113.629 -48.710 56.719 1.00 63.06 ? 427 ARG B O 1 ATOM 2376 C CB . ARG B 1 103 ? 113.179 -51.330 55.027 1.00 66.41 ? 427 ARG B CB 1 ATOM 2377 C CG . ARG B 1 103 ? 112.297 -52.466 54.549 1.00 66.55 ? 427 ARG B CG 1 ATOM 2378 C CD . ARG B 1 103 ? 112.845 -53.015 53.244 1.00 66.57 ? 427 ARG B CD 1 ATOM 2379 N NE . ARG B 1 103 ? 112.065 -54.144 52.757 1.00 66.65 ? 427 ARG B NE 1 ATOM 2380 C CZ . ARG B 1 103 ? 112.393 -54.889 51.705 1.00 66.33 ? 427 ARG B CZ 1 ATOM 2381 N NH1 . ARG B 1 103 ? 113.496 -54.629 51.018 1.00 66.11 ? 427 ARG B NH1 1 ATOM 2382 N NH2 . ARG B 1 103 ? 111.612 -55.898 51.341 1.00 66.07 ? 427 ARG B NH2 1 ATOM 2383 N N . ALA B 1 104 ? 115.257 -50.164 57.244 1.00 61.38 ? 428 ALA B N 1 ATOM 2384 C CA . ALA B 1 104 ? 116.258 -49.110 57.381 1.00 59.20 ? 428 ALA B CA 1 ATOM 2385 C C . ALA B 1 104 ? 116.579 -48.508 56.006 1.00 57.02 ? 428 ALA B C 1 ATOM 2386 O O . ALA B 1 104 ? 116.650 -49.220 55.008 1.00 57.05 ? 428 ALA B O 1 ATOM 2387 C CB . ALA B 1 104 ? 117.514 -49.654 58.053 1.00 59.33 ? 428 ALA B CB 1 ATOM 2388 N N . LEU B 1 105 ? 116.763 -47.191 55.950 1.00 55.14 ? 429 LEU B N 1 ATOM 2389 C CA . LEU B 1 105 ? 117.040 -46.504 54.687 1.00 53.99 ? 429 LEU B CA 1 ATOM 2390 C C . LEU B 1 105 ? 118.540 -46.202 54.436 1.00 51.48 ? 429 LEU B C 1 ATOM 2391 O O . LEU B 1 105 ? 119.238 -45.690 55.307 1.00 48.41 ? 429 LEU B O 1 ATOM 2392 C CB . LEU B 1 105 ? 116.214 -45.218 54.652 1.00 54.83 ? 429 LEU B CB 1 ATOM 2393 C CG . LEU B 1 105 ? 115.702 -44.677 53.304 1.00 55.93 ? 429 LEU B CG 1 ATOM 2394 C CD1 . LEU B 1 105 ? 114.868 -45.696 52.496 1.00 55.61 ? 429 LEU B CD1 1 ATOM 2395 C CD2 . LEU B 1 105 ? 114.861 -43.436 53.593 1.00 55.81 ? 429 LEU B CD2 1 ATOM 2396 N N . MET B 1 106 ? 119.030 -46.542 53.245 1.00 49.50 ? 430 MET B N 1 ATOM 2397 C CA . MET B 1 106 ? 120.453 -46.443 52.916 1.00 48.44 ? 430 MET B CA 1 ATOM 2398 C C . MET B 1 106 ? 120.666 -45.340 51.887 1.00 44.53 ? 430 MET B C 1 ATOM 2399 O O . MET B 1 106 ? 119.973 -45.282 50.879 1.00 43.71 ? 430 MET B O 1 ATOM 2400 C CB . MET B 1 106 ? 120.988 -47.767 52.338 1.00 51.20 ? 430 MET B CB 1 ATOM 2401 C CG . MET B 1 106 ? 121.819 -48.653 53.296 1.00 53.33 ? 430 MET B CG 1 ATOM 2402 S SD . MET B 1 106 ? 123.582 -48.190 53.540 1.00 56.38 ? 430 MET B SD 1 ATOM 2403 C CE . MET B 1 106 ? 124.148 -47.868 51.857 1.00 54.98 ? 430 MET B CE 1 ATOM 2404 N N . ARG B 1 107 ? 121.629 -44.464 52.133 1.00 40.39 ? 431 ARG B N 1 ATOM 2405 C CA . ARG B 1 107 ? 122.056 -43.530 51.113 1.00 39.60 ? 431 ARG B CA 1 ATOM 2406 C C . ARG B 1 107 ? 123.578 -43.609 50.948 1.00 36.29 ? 431 ARG B C 1 ATOM 2407 O O . ARG B 1 107 ? 124.290 -43.835 51.924 1.00 34.82 ? 431 ARG B O 1 ATOM 2408 C CB . ARG B 1 107 ? 121.593 -42.113 51.464 1.00 41.58 ? 431 ARG B CB 1 ATOM 2409 C CG . ARG B 1 107 ? 120.171 -41.782 50.999 1.00 43.98 ? 431 ARG B CG 1 ATOM 2410 C CD . ARG B 1 107 ? 119.981 -42.229 49.551 1.00 47.84 ? 431 ARG B CD 1 ATOM 2411 N NE . ARG B 1 107 ? 118.793 -41.709 48.863 1.00 50.14 ? 431 ARG B NE 1 ATOM 2412 C CZ . ARG B 1 107 ? 118.286 -42.237 47.744 1.00 51.05 ? 431 ARG B CZ 1 ATOM 2413 N NH1 . ARG B 1 107 ? 118.838 -43.301 47.175 1.00 51.01 ? 431 ARG B NH1 1 ATOM 2414 N NH2 . ARG B 1 107 ? 117.211 -41.702 47.182 1.00 52.37 ? 431 ARG B NH2 1 ATOM 2415 N N . SER B 1 108 ? 124.078 -43.452 49.722 1.00 31.04 ? 432 SER B N 1 ATOM 2416 C CA . SER B 1 108 ? 125.523 -43.434 49.523 1.00 28.77 ? 432 SER B CA 1 ATOM 2417 C C . SER B 1 108 ? 126.026 -42.309 48.636 1.00 26.64 ? 432 SER B C 1 ATOM 2418 O O . SER B 1 108 ? 125.275 -41.649 47.937 1.00 24.21 ? 432 SER B O 1 ATOM 2419 C CB . SER B 1 108 ? 126.031 -44.783 49.021 1.00 30.33 ? 432 SER B CB 1 ATOM 2420 O OG . SER B 1 108 ? 125.645 -45.040 47.687 1.00 31.20 ? 432 SER B OG 1 ATOM 2421 N N . THR B 1 109 ? 127.326 -42.057 48.689 1.00 26.40 ? 433 THR B N 1 ATOM 2422 C CA . THR B 1 109 ? 127.896 -40.954 47.936 1.00 23.10 ? 433 THR B CA 1 ATOM 2423 C C . THR B 1 109 ? 129.317 -41.265 47.556 1.00 22.02 ? 433 THR B C 1 ATOM 2424 O O . THR B 1 109 ? 130.023 -41.951 48.275 1.00 20.42 ? 433 THR B O 1 ATOM 2425 C CB . THR B 1 109 ? 127.856 -39.615 48.688 1.00 24.21 ? 433 THR B CB 1 ATOM 2426 O OG1 . THR B 1 109 ? 128.468 -38.612 47.866 1.00 24.00 ? 433 THR B OG1 1 ATOM 2427 C CG2 . THR B 1 109 ? 128.586 -39.683 50.027 1.00 24.71 ? 433 THR B CG2 1 ATOM 2428 N N . THR B 1 110 ? 129.725 -40.778 46.393 1.00 22.91 ? 434 THR B N 1 ATOM 2429 C CA . THR B 1 110 ? 131.086 -40.973 45.913 1.00 25.48 ? 434 THR B CA 1 ATOM 2430 C C . THR B 1 110 ? 131.421 -39.865 44.903 1.00 27.01 ? 434 THR B C 1 ATOM 2431 O O . THR B 1 110 ? 130.534 -39.123 44.494 1.00 27.21 ? 434 THR B O 1 ATOM 2432 C CB . THR B 1 110 ? 131.302 -42.396 45.299 1.00 24.92 ? 434 THR B CB 1 ATOM 2433 O OG1 . THR B 1 110 ? 132.686 -42.547 44.977 1.00 25.53 ? 434 THR B OG1 1 ATOM 2434 C CG2 . THR B 1 110 ? 130.477 -42.636 44.027 1.00 22.34 ? 434 THR B CG2 1 ATOM 2435 N N . LYS B 1 111 ? 132.677 -39.717 44.511 1.00 28.34 ? 435 LYS B N 1 ATOM 2436 C CA . LYS B 1 111 ? 132.984 -38.677 43.533 1.00 32.02 ? 435 LYS B CA 1 ATOM 2437 C C . LYS B 1 111 ? 132.230 -38.949 42.213 1.00 34.38 ? 435 LYS B C 1 ATOM 2438 O O . LYS B 1 111 ? 132.094 -40.097 41.799 1.00 33.82 ? 435 LYS B O 1 ATOM 2439 C CB . LYS B 1 111 ? 134.494 -38.580 43.310 1.00 31.91 ? 435 LYS B CB 1 ATOM 2440 C CG . LYS B 1 111 ? 135.114 -39.828 42.681 1.00 32.52 ? 435 LYS B CG 1 ATOM 2441 C CD . LYS B 1 111 ? 136.581 -39.644 42.262 1.00 33.28 ? 435 LYS B CD 1 ATOM 2442 C CE . LYS B 1 111 ? 136.734 -38.584 41.136 1.00 34.65 ? 435 LYS B CE 1 ATOM 2443 N NZ . LYS B 1 111 ? 138.157 -38.284 40.766 1.00 35.90 ? 435 LYS B NZ 1 ATOM 2444 N N . THR B 1 112 ? 131.721 -37.914 41.551 1.00 38.13 ? 436 THR B N 1 ATOM 2445 C CA . THR B 1 112 ? 130.983 -38.133 40.299 1.00 41.70 ? 436 THR B CA 1 ATOM 2446 C C . THR B 1 112 ? 131.885 -38.558 39.145 1.00 43.36 ? 436 THR B C 1 ATOM 2447 O O . THR B 1 112 ? 132.987 -38.047 38.982 1.00 43.37 ? 436 THR B O 1 ATOM 2448 C CB . THR B 1 112 ? 130.194 -36.897 39.852 1.00 43.54 ? 436 THR B CB 1 ATOM 2449 O OG1 . THR B 1 112 ? 129.345 -36.452 40.923 1.00 44.94 ? 436 THR B OG1 1 ATOM 2450 C CG2 . THR B 1 112 ? 129.339 -37.230 38.620 1.00 43.50 ? 436 THR B CG2 1 ATOM 2451 N N . SER B 1 113 ? 131.427 -39.517 38.347 1.00 45.74 ? 437 SER B N 1 ATOM 2452 C CA . SER B 1 113 ? 132.259 -40.006 37.260 1.00 47.47 ? 437 SER B CA 1 ATOM 2453 C C . SER B 1 113 ? 132.005 -39.175 36.001 1.00 46.82 ? 437 SER B C 1 ATOM 2454 O O . SER B 1 113 ? 131.334 -38.139 36.050 1.00 47.47 ? 437 SER B O 1 ATOM 2455 C CB . SER B 1 113 ? 132.008 -41.496 37.016 1.00 49.36 ? 437 SER B CB 1 ATOM 2456 O OG . SER B 1 113 ? 130.680 -41.732 36.567 1.00 51.74 ? 437 SER B OG 1 ATOM 2457 N N . GLY B 1 114 ? 132.549 -39.625 34.874 1.00 45.29 ? 438 GLY B N 1 ATOM 2458 C CA . GLY B 1 114 ? 132.340 -38.941 33.605 1.00 43.25 ? 438 GLY B CA 1 ATOM 2459 C C . GLY B 1 114 ? 133.535 -38.110 33.189 1.00 42.26 ? 438 GLY B C 1 ATOM 2460 O O . GLY B 1 114 ? 134.506 -37.961 33.936 1.00 43.16 ? 438 GLY B O 1 ATOM 2461 N N . PRO B 1 115 ? 133.471 -37.549 31.986 1.00 40.74 ? 439 PRO B N 1 ATOM 2462 C CA . PRO B 1 115 ? 134.554 -36.704 31.501 1.00 40.77 ? 439 PRO B CA 1 ATOM 2463 C C . PRO B 1 115 ? 134.740 -35.472 32.377 1.00 39.40 ? 439 PRO B C 1 ATOM 2464 O O . PRO B 1 115 ? 133.810 -35.061 33.060 1.00 38.54 ? 439 PRO B O 1 ATOM 2465 C CB . PRO B 1 115 ? 134.078 -36.274 30.112 1.00 41.45 ? 439 PRO B CB 1 ATOM 2466 C CG . PRO B 1 115 ? 132.843 -37.101 29.811 1.00 41.81 ? 439 PRO B CG 1 ATOM 2467 C CD . PRO B 1 115 ? 132.287 -37.528 31.114 1.00 41.20 ? 439 PRO B CD 1 ATOM 2468 N N . ARG B 1 116 ? 135.934 -34.897 32.349 1.00 38.30 ? 440 ARG B N 1 ATOM 2469 C CA . ARG B 1 116 ? 136.224 -33.693 33.098 1.00 38.75 ? 440 ARG B CA 1 ATOM 2470 C C . ARG B 1 116 ? 136.277 -32.528 32.116 1.00 35.51 ? 440 ARG B C 1 ATOM 2471 O O . ARG B 1 116 ? 136.549 -32.720 30.936 1.00 36.74 ? 440 ARG B O 1 ATOM 2472 C CB . ARG B 1 116 ? 137.591 -33.768 33.786 1.00 41.60 ? 440 ARG B CB 1 ATOM 2473 C CG . ARG B 1 116 ? 137.942 -35.052 34.530 1.00 44.29 ? 440 ARG B CG 1 ATOM 2474 C CD . ARG B 1 116 ? 137.339 -35.120 35.922 1.00 45.72 ? 440 ARG B CD 1 ATOM 2475 N NE . ARG B 1 116 ? 136.209 -36.042 35.929 1.00 48.14 ? 440 ARG B NE 1 ATOM 2476 C CZ . ARG B 1 116 ? 135.642 -36.547 37.027 1.00 49.39 ? 440 ARG B CZ 1 ATOM 2477 N NH1 . ARG B 1 116 ? 136.094 -36.214 38.229 1.00 49.25 ? 440 ARG B NH1 1 ATOM 2478 N NH2 . ARG B 1 116 ? 134.612 -37.385 36.920 1.00 49.57 ? 440 ARG B NH2 1 ATOM 2479 N N . ALA B 1 117 ? 136.040 -31.315 32.592 1.00 30.91 ? 441 ALA B N 1 ATOM 2480 C CA . ALA B 1 117 ? 136.259 -30.139 31.750 1.00 28.91 ? 441 ALA B CA 1 ATOM 2481 C C . ALA B 1 117 ? 136.275 -28.882 32.621 1.00 26.53 ? 441 ALA B C 1 ATOM 2482 O O . ALA B 1 117 ? 135.398 -28.693 33.462 1.00 24.12 ? 441 ALA B O 1 ATOM 2483 C CB . ALA B 1 117 ? 135.196 -30.037 30.641 1.00 26.71 ? 441 ALA B CB 1 ATOM 2484 N N . ALA B 1 118 ? 137.295 -28.057 32.402 1.00 24.92 ? 442 ALA B N 1 ATOM 2485 C CA . ALA B 1 118 ? 137.562 -26.889 33.215 1.00 26.07 ? 442 ALA B CA 1 ATOM 2486 C C . ALA B 1 118 ? 136.483 -25.854 32.949 1.00 26.54 ? 442 ALA B C 1 ATOM 2487 O O . ALA B 1 118 ? 135.980 -25.765 31.840 1.00 28.06 ? 442 ALA B O 1 ATOM 2488 C CB . ALA B 1 118 ? 138.921 -26.316 32.866 1.00 25.74 ? 442 ALA B CB 1 ATOM 2489 N N . PRO B 1 119 ? 136.121 -25.072 33.970 1.00 25.80 ? 443 PRO B N 1 ATOM 2490 C CA . PRO B 1 119 ? 135.163 -23.999 33.793 1.00 24.72 ? 443 PRO B CA 1 ATOM 2491 C C . PRO B 1 119 ? 135.818 -22.808 33.092 1.00 24.41 ? 443 PRO B C 1 ATOM 2492 O O . PRO B 1 119 ? 136.989 -22.507 33.371 1.00 23.27 ? 443 PRO B O 1 ATOM 2493 C CB . PRO B 1 119 ? 134.791 -23.653 35.242 1.00 23.87 ? 443 PRO B CB 1 ATOM 2494 C CG . PRO B 1 119 ? 136.027 -23.903 35.992 1.00 23.52 ? 443 PRO B CG 1 ATOM 2495 C CD . PRO B 1 119 ? 136.614 -25.130 35.355 1.00 24.30 ? 443 PRO B CD 1 ATOM 2496 N N . GLU B 1 120 ? 135.067 -22.176 32.186 1.00 23.66 ? 444 GLU B N 1 ATOM 2497 C CA . GLU B 1 120 ? 135.322 -20.806 31.709 1.00 22.64 ? 444 GLU B CA 1 ATOM 2498 C C . GLU B 1 120 ? 134.752 -19.861 32.758 1.00 23.45 ? 444 GLU B C 1 ATOM 2499 O O . GLU B 1 120 ? 133.656 -20.094 33.283 1.00 25.39 ? 444 GLU B O 1 ATOM 2500 C CB . GLU B 1 120 ? 134.601 -20.543 30.368 1.00 23.57 ? 444 GLU B CB 1 ATOM 2501 C CG . GLU B 1 120 ? 134.804 -21.655 29.300 1.00 24.56 ? 444 GLU B CG 1 ATOM 2502 C CD . GLU B 1 120 ? 133.992 -21.473 28.014 1.00 25.30 ? 444 GLU B CD 1 ATOM 2503 O OE1 . GLU B 1 120 ? 133.397 -20.383 27.811 1.00 22.10 ? 444 GLU B OE1 1 ATOM 2504 O OE2 . GLU B 1 120 ? 133.979 -22.428 27.186 1.00 26.18 ? 444 GLU B OE2 1 ATOM 2505 N N . VAL B 1 121 ? 135.480 -18.797 33.078 1.00 22.28 ? 445 VAL B N 1 ATOM 2506 C CA . VAL B 1 121 ? 135.021 -17.838 34.060 1.00 20.97 ? 445 VAL B CA 1 ATOM 2507 C C . VAL B 1 121 ? 135.018 -16.450 33.444 1.00 22.35 ? 445 VAL B C 1 ATOM 2508 O O . VAL B 1 121 ? 135.980 -16.033 32.807 1.00 22.02 ? 445 VAL B O 1 ATOM 2509 C CB . VAL B 1 121 ? 135.916 -17.824 35.332 1.00 19.50 ? 445 VAL B CB 1 ATOM 2510 C CG1 . VAL B 1 121 ? 135.404 -16.813 36.377 1.00 15.53 ? 445 VAL B CG1 1 ATOM 2511 C CG2 . VAL B 1 121 ? 135.973 -19.182 35.905 1.00 18.84 ? 445 VAL B CG2 1 ATOM 2512 N N . TYR B 1 122 ? 133.921 -15.737 33.673 1.00 22.57 ? 446 TYR B N 1 ATOM 2513 C CA . TYR B 1 122 ? 133.763 -14.385 33.192 1.00 20.53 ? 446 TYR B CA 1 ATOM 2514 C C . TYR B 1 122 ? 133.094 -13.518 34.264 1.00 21.71 ? 446 TYR B C 1 ATOM 2515 O O . TYR B 1 122 ? 132.134 -13.936 34.924 1.00 22.23 ? 446 TYR B O 1 ATOM 2516 C CB . TYR B 1 122 ? 132.874 -14.423 31.982 1.00 20.44 ? 446 TYR B CB 1 ATOM 2517 C CG . TYR B 1 122 ? 133.248 -15.386 30.879 1.00 19.53 ? 446 TYR B CG 1 ATOM 2518 C CD1 . TYR B 1 122 ? 132.581 -16.586 30.737 1.00 19.94 ? 446 TYR B CD1 1 ATOM 2519 C CD2 . TYR B 1 122 ? 134.219 -15.065 29.939 1.00 18.12 ? 446 TYR B CD2 1 ATOM 2520 C CE1 . TYR B 1 122 ? 132.891 -17.455 29.696 1.00 20.55 ? 446 TYR B CE1 1 ATOM 2521 C CE2 . TYR B 1 122 ? 134.533 -15.920 28.897 1.00 18.31 ? 446 TYR B CE2 1 ATOM 2522 C CZ . TYR B 1 122 ? 133.872 -17.120 28.771 1.00 20.01 ? 446 TYR B CZ 1 ATOM 2523 O OH . TYR B 1 122 ? 134.183 -18.009 27.740 1.00 20.49 ? 446 TYR B OH 1 ATOM 2524 N N . ALA B 1 123 ? 133.616 -12.313 34.444 1.00 22.08 ? 447 ALA B N 1 ATOM 2525 C CA . ALA B 1 123 ? 133.243 -11.481 35.580 1.00 24.00 ? 447 ALA B CA 1 ATOM 2526 C C . ALA B 1 123 ? 132.800 -10.110 35.074 1.00 23.58 ? 447 ALA B C 1 ATOM 2527 O O . ALA B 1 123 ? 133.476 -9.528 34.219 1.00 23.22 ? 447 ALA B O 1 ATOM 2528 C CB . ALA B 1 123 ? 134.424 -11.363 36.565 1.00 21.73 ? 447 ALA B CB 1 ATOM 2529 N N . PHE B 1 124 ? 131.671 -9.613 35.591 1.00 23.44 ? 448 PHE B N 1 ATOM 2530 C CA . PHE B 1 124 ? 131.016 -8.416 35.045 1.00 23.80 ? 448 PHE B CA 1 ATOM 2531 C C . PHE B 1 124 ? 130.575 -7.472 36.151 1.00 23.97 ? 448 PHE B C 1 ATOM 2532 O O . PHE B 1 124 ? 130.143 -7.901 37.216 1.00 22.99 ? 448 PHE B O 1 ATOM 2533 C CB . PHE B 1 124 ? 129.727 -8.755 34.274 1.00 24.64 ? 448 PHE B CB 1 ATOM 2534 C CG . PHE B 1 124 ? 129.902 -9.681 33.101 1.00 24.90 ? 448 PHE B CG 1 ATOM 2535 C CD1 . PHE B 1 124 ? 129.504 -11.011 33.191 1.00 25.43 ? 448 PHE B CD1 1 ATOM 2536 C CD2 . PHE B 1 124 ? 130.398 -9.222 31.900 1.00 24.83 ? 448 PHE B CD2 1 ATOM 2537 C CE1 . PHE B 1 124 ? 129.643 -11.876 32.107 1.00 25.46 ? 448 PHE B CE1 1 ATOM 2538 C CE2 . PHE B 1 124 ? 130.530 -10.086 30.814 1.00 25.77 ? 448 PHE B CE2 1 ATOM 2539 C CZ . PHE B 1 124 ? 130.155 -11.417 30.928 1.00 24.91 ? 448 PHE B CZ 1 ATOM 2540 N N . ALA B 1 125 ? 130.621 -6.174 35.896 1.00 25.32 ? 449 ALA B N 1 ATOM 2541 C CA . ALA B 1 125 ? 130.053 -5.251 36.885 1.00 25.72 ? 449 ALA B CA 1 ATOM 2542 C C . ALA B 1 125 ? 128.838 -4.592 36.282 1.00 24.51 ? 449 ALA B C 1 ATOM 2543 O O . ALA B 1 125 ? 128.846 -4.257 35.122 1.00 26.77 ? 449 ALA B O 1 ATOM 2544 C CB . ALA B 1 125 ? 131.070 -4.206 37.300 1.00 26.30 ? 449 ALA B CB 1 ATOM 2545 N N . THR B 1 126 ? 127.778 -4.418 37.047 1.00 24.03 ? 450 THR B N 1 ATOM 2546 C CA . THR B 1 126 ? 126.611 -3.766 36.485 1.00 25.39 ? 450 THR B CA 1 ATOM 2547 C C . THR B 1 126 ? 126.847 -2.271 36.492 1.00 25.65 ? 450 THR B C 1 ATOM 2548 O O . THR B 1 126 ? 127.689 -1.789 37.243 1.00 26.72 ? 450 THR B O 1 ATOM 2549 C CB . THR B 1 126 ? 125.351 -4.059 37.301 1.00 24.99 ? 450 THR B CB 1 ATOM 2550 O OG1 . THR B 1 126 ? 125.592 -3.750 38.678 1.00 24.46 ? 450 THR B OG1 1 ATOM 2551 C CG2 . THR B 1 126 ? 125.002 -5.517 37.171 1.00 25.85 ? 450 THR B CG2 1 ATOM 2552 N N . PRO B 1 127 ? 126.098 -1.529 35.661 1.00 26.85 ? 451 PRO B N 1 ATOM 2553 C CA . PRO B 1 127 ? 126.168 -0.076 35.719 1.00 27.02 ? 451 PRO B CA 1 ATOM 2554 C C . PRO B 1 127 ? 125.352 0.413 36.887 1.00 28.28 ? 451 PRO B C 1 ATOM 2555 O O . PRO B 1 127 ? 124.703 -0.385 37.558 1.00 26.78 ? 451 PRO B O 1 ATOM 2556 C CB . PRO B 1 127 ? 125.504 0.387 34.415 1.00 26.78 ? 451 PRO B CB 1 ATOM 2557 C CG . PRO B 1 127 ? 125.179 -0.861 33.636 1.00 26.87 ? 451 PRO B CG 1 ATOM 2558 C CD . PRO B 1 127 ? 125.184 -1.996 34.605 1.00 27.12 ? 451 PRO B CD 1 ATOM 2559 N N . GLU B 1 128 ? 125.381 1.723 37.099 1.00 30.54 ? 452 GLU B N 1 ATOM 2560 C CA . GLU B 1 128 ? 124.632 2.333 38.169 1.00 32.31 ? 452 GLU B CA 1 ATOM 2561 C C . GLU B 1 128 ? 123.170 2.231 37.806 1.00 32.13 ? 452 GLU B C 1 ATOM 2562 O O . GLU B 1 128 ? 122.803 2.424 36.656 1.00 30.53 ? 452 GLU B O 1 ATOM 2563 C CB . GLU B 1 128 ? 125.027 3.805 38.336 1.00 34.60 ? 452 GLU B CB 1 ATOM 2564 C CG . GLU B 1 128 ? 124.572 4.405 39.661 1.00 35.93 ? 452 GLU B CG 1 ATOM 2565 C CD . GLU B 1 128 ? 124.804 5.894 39.764 1.00 37.83 ? 452 GLU B CD 1 ATOM 2566 O OE1 . GLU B 1 128 ? 124.274 6.651 38.927 1.00 39.38 ? 452 GLU B OE1 1 ATOM 2567 O OE2 . GLU B 1 128 ? 125.497 6.321 40.709 1.00 40.69 ? 452 GLU B OE2 1 ATOM 2568 N N . TRP B 1 129 ? 122.350 1.917 38.799 1.00 34.50 ? 453 TRP B N 1 ATOM 2569 C CA . TRP B 1 129 ? 120.897 2.000 38.673 1.00 36.72 ? 453 TRP B CA 1 ATOM 2570 C C . TRP B 1 129 ? 120.407 3.172 39.522 1.00 36.63 ? 453 TRP B C 1 ATOM 2571 O O . TRP B 1 129 ? 120.999 3.483 40.549 1.00 36.00 ? 453 TRP B O 1 ATOM 2572 C CB . TRP B 1 129 ? 120.251 0.689 39.149 1.00 37.80 ? 453 TRP B CB 1 ATOM 2573 C CG . TRP B 1 129 ? 118.821 0.511 38.694 1.00 38.47 ? 453 TRP B CG 1 ATOM 2574 C CD1 . TRP B 1 129 ? 117.689 0.893 39.370 1.00 38.61 ? 453 TRP B CD1 1 ATOM 2575 C CD2 . TRP B 1 129 ? 118.369 -0.084 37.462 1.00 38.50 ? 453 TRP B CD2 1 ATOM 2576 N NE1 . TRP B 1 129 ? 116.566 0.578 38.632 1.00 38.24 ? 453 TRP B NE1 1 ATOM 2577 C CE2 . TRP B 1 129 ? 116.956 -0.022 37.462 1.00 38.41 ? 453 TRP B CE2 1 ATOM 2578 C CE3 . TRP B 1 129 ? 119.019 -0.659 36.363 1.00 38.05 ? 453 TRP B CE3 1 ATOM 2579 C CZ2 . TRP B 1 129 ? 116.188 -0.516 36.407 1.00 38.59 ? 453 TRP B CZ2 1 ATOM 2580 C CZ3 . TRP B 1 129 ? 118.248 -1.143 35.315 1.00 38.37 ? 453 TRP B CZ3 1 ATOM 2581 C CH2 . TRP B 1 129 ? 116.851 -1.072 35.346 1.00 37.95 ? 453 TRP B CH2 1 ATOM 2582 N N . PRO B 1 130 ? 119.337 3.842 39.085 1.00 38.25 ? 454 PRO B N 1 ATOM 2583 C CA . PRO B 1 130 ? 118.699 4.878 39.882 1.00 40.28 ? 454 PRO B CA 1 ATOM 2584 C C . PRO B 1 130 ? 118.376 4.423 41.305 1.00 42.05 ? 454 PRO B C 1 ATOM 2585 O O . PRO B 1 130 ? 117.717 3.402 41.490 1.00 42.79 ? 454 PRO B O 1 ATOM 2586 C CB . PRO B 1 130 ? 117.405 5.151 39.110 1.00 39.60 ? 454 PRO B CB 1 ATOM 2587 C CG . PRO B 1 130 ? 117.726 4.855 37.712 1.00 38.59 ? 454 PRO B CG 1 ATOM 2588 C CD . PRO B 1 130 ? 118.744 3.750 37.742 1.00 38.94 ? 454 PRO B CD 1 ATOM 2589 N N . GLY B 1 131 ? 118.840 5.170 42.302 1.00 44.40 ? 455 GLY B N 1 ATOM 2590 C CA . GLY B 1 131 ? 118.504 4.879 43.692 1.00 46.67 ? 455 GLY B CA 1 ATOM 2591 C C . GLY B 1 131 ? 119.467 3.897 44.334 1.00 49.09 ? 455 GLY B C 1 ATOM 2592 O O . GLY B 1 131 ? 119.130 3.217 45.313 1.00 50.68 ? 455 GLY B O 1 ATOM 2593 N N . SER B 1 132 ? 120.674 3.833 43.779 1.00 50.17 ? 456 SER B N 1 ATOM 2594 C CA . SER B 1 132 ? 121.713 2.926 44.253 1.00 50.46 ? 456 SER B CA 1 ATOM 2595 C C . SER B 1 132 ? 123.086 3.446 43.830 1.00 50.20 ? 456 SER B C 1 ATOM 2596 O O . SER B 1 132 ? 123.890 2.739 43.218 1.00 50.25 ? 456 SER B O 1 ATOM 2597 C CB . SER B 1 132 ? 121.473 1.521 43.697 1.00 50.84 ? 456 SER B CB 1 ATOM 2598 O OG . SER B 1 132 ? 120.164 1.091 44.025 1.00 51.40 ? 456 SER B OG 1 ATOM 2599 N N . ARG B 1 133 ? 123.340 4.701 44.170 1.00 49.67 ? 457 ARG B N 1 ATOM 2600 C CA . ARG B 1 133 ? 124.594 5.358 43.841 1.00 49.84 ? 457 ARG B CA 1 ATOM 2601 C C . ARG B 1 133 ? 125.800 4.707 44.500 1.00 48.45 ? 457 ARG B C 1 ATOM 2602 O O . ARG B 1 133 ? 126.899 4.743 43.957 1.00 46.99 ? 457 ARG B O 1 ATOM 2603 C CB . ARG B 1 133 ? 124.543 6.811 44.317 1.00 51.20 ? 457 ARG B CB 1 ATOM 2604 C CG . ARG B 1 133 ? 123.713 7.734 43.445 1.00 51.95 ? 457 ARG B CG 1 ATOM 2605 C CD . ARG B 1 133 ? 123.918 9.171 43.873 1.00 52.50 ? 457 ARG B CD 1 ATOM 2606 N NE . ARG B 1 133 ? 123.829 10.110 42.755 1.00 53.15 ? 457 ARG B NE 1 ATOM 2607 C CZ . ARG B 1 133 ? 124.027 11.423 42.864 1.00 53.09 ? 457 ARG B CZ 1 ATOM 2608 N NH1 . ARG B 1 133 ? 124.326 11.965 44.043 1.00 52.44 ? 457 ARG B NH1 1 ATOM 2609 N NH2 . ARG B 1 133 ? 123.923 12.196 41.790 1.00 52.93 ? 457 ARG B NH2 1 ATOM 2610 N N . ASP B 1 134 ? 125.593 4.133 45.681 1.00 47.86 ? 458 ASP B N 1 ATOM 2611 C CA . ASP B 1 134 ? 126.701 3.755 46.554 1.00 47.04 ? 458 ASP B CA 1 ATOM 2612 C C . ASP B 1 134 ? 126.953 2.262 46.540 1.00 45.85 ? 458 ASP B C 1 ATOM 2613 O O . ASP B 1 134 ? 127.764 1.744 47.311 1.00 46.11 ? 458 ASP B O 1 ATOM 2614 C CB . ASP B 1 134 ? 126.436 4.247 47.983 1.00 47.28 ? 458 ASP B CB 1 ATOM 2615 C CG . ASP B 1 134 ? 126.614 5.749 48.111 1.00 47.37 ? 458 ASP B CG 1 ATOM 2616 O OD1 . ASP B 1 134 ? 127.693 6.250 47.724 1.00 46.93 ? 458 ASP B OD1 1 ATOM 2617 O OD2 . ASP B 1 134 ? 125.680 6.426 48.587 1.00 47.46 ? 458 ASP B OD2 1 ATOM 2618 N N . LYS B 1 135 ? 126.254 1.573 45.649 1.00 45.41 ? 459 LYS B N 1 ATOM 2619 C CA . LYS B 1 135 ? 126.413 0.130 45.512 1.00 45.11 ? 459 LYS B CA 1 ATOM 2620 C C . LYS B 1 135 ? 126.290 -0.337 44.052 1.00 43.29 ? 459 LYS B C 1 ATOM 2621 O O . LYS B 1 135 ? 125.593 0.262 43.237 1.00 43.05 ? 459 LYS B O 1 ATOM 2622 C CB . LYS B 1 135 ? 125.420 -0.594 46.430 1.00 45.62 ? 459 LYS B CB 1 ATOM 2623 C CG . LYS B 1 135 ? 123.966 -0.291 46.132 1.00 46.69 ? 459 LYS B CG 1 ATOM 2624 C CD . LYS B 1 135 ? 123.047 -0.827 47.223 1.00 47.62 ? 459 LYS B CD 1 ATOM 2625 C CE . LYS B 1 135 ? 121.594 -0.506 46.888 1.00 48.73 ? 459 LYS B CE 1 ATOM 2626 N NZ . LYS B 1 135 ? 120.620 -1.293 47.691 1.00 49.57 ? 459 LYS B NZ 1 ATOM 2627 N N . ARG B 1 136 ? 127.009 -1.405 43.730 1.00 41.83 ? 460 ARG B N 1 ATOM 2628 C CA . ARG B 1 136 ? 126.939 -2.026 42.423 1.00 40.11 ? 460 ARG B CA 1 ATOM 2629 C C . ARG B 1 136 ? 126.670 -3.505 42.631 1.00 38.38 ? 460 ARG B C 1 ATOM 2630 O O . ARG B 1 136 ? 126.811 -4.012 43.745 1.00 37.86 ? 460 ARG B O 1 ATOM 2631 C CB . ARG B 1 136 ? 128.249 -1.845 41.658 1.00 40.60 ? 460 ARG B CB 1 ATOM 2632 C CG . ARG B 1 136 ? 128.519 -0.418 41.229 1.00 41.59 ? 460 ARG B CG 1 ATOM 2633 C CD . ARG B 1 136 ? 127.765 -0.058 39.957 1.00 43.05 ? 460 ARG B CD 1 ATOM 2634 N NE . ARG B 1 136 ? 128.216 1.219 39.414 1.00 43.99 ? 460 ARG B NE 1 ATOM 2635 C CZ . ARG B 1 136 ? 127.909 2.398 39.940 1.00 46.39 ? 460 ARG B CZ 1 ATOM 2636 N NH1 . ARG B 1 136 ? 127.139 2.504 41.026 1.00 47.16 ? 460 ARG B NH1 1 ATOM 2637 N NH2 . ARG B 1 136 ? 128.384 3.489 39.371 1.00 48.18 ? 460 ARG B NH2 1 ATOM 2638 N N . THR B 1 137 ? 126.273 -4.191 41.563 1.00 35.15 ? 461 THR B N 1 ATOM 2639 C CA . THR B 1 137 ? 126.145 -5.628 41.624 1.00 32.73 ? 461 THR B CA 1 ATOM 2640 C C . THR B 1 137 ? 127.213 -6.190 40.707 1.00 31.45 ? 461 THR B C 1 ATOM 2641 O O . THR B 1 137 ? 127.348 -5.752 39.566 1.00 32.15 ? 461 THR B O 1 ATOM 2642 C CB . THR B 1 137 ? 124.734 -6.081 41.204 1.00 32.76 ? 461 THR B CB 1 ATOM 2643 O OG1 . THR B 1 137 ? 123.787 -5.550 42.130 1.00 33.29 ? 461 THR B OG1 1 ATOM 2644 C CG2 . THR B 1 137 ? 124.601 -7.579 41.232 1.00 31.21 ? 461 THR B CG2 1 ATOM 2645 N N . LEU B 1 138 ? 127.985 -7.143 41.214 1.00 29.36 ? 462 LEU B N 1 ATOM 2646 C CA . LEU B 1 138 ? 128.915 -7.891 40.375 1.00 28.09 ? 462 LEU B CA 1 ATOM 2647 C C . LEU B 1 138 ? 128.341 -9.268 40.081 1.00 28.01 ? 462 LEU B C 1 ATOM 2648 O O . LEU B 1 138 ? 127.808 -9.949 40.965 1.00 29.59 ? 462 LEU B O 1 ATOM 2649 C CB . LEU B 1 138 ? 130.261 -8.058 41.082 1.00 26.80 ? 462 LEU B CB 1 ATOM 2650 C CG . LEU B 1 138 ? 130.918 -6.765 41.578 1.00 27.25 ? 462 LEU B CG 1 ATOM 2651 C CD1 . LEU B 1 138 ? 132.339 -7.058 42.090 1.00 25.63 ? 462 LEU B CD1 1 ATOM 2652 C CD2 . LEU B 1 138 ? 130.913 -5.727 40.470 1.00 26.72 ? 462 LEU B CD2 1 ATOM 2653 N N . ALA B 1 139 ? 128.470 -9.716 38.848 1.00 27.24 ? 463 ALA B N 1 ATOM 2654 C CA . ALA B 1 139 ? 127.985 -11.049 38.517 1.00 26.48 ? 463 ALA B CA 1 ATOM 2655 C C . ALA B 1 139 ? 129.127 -11.820 37.901 1.00 26.57 ? 463 ALA B C 1 ATOM 2656 O O . ALA B 1 139 ? 129.988 -11.245 37.235 1.00 30.23 ? 463 ALA B O 1 ATOM 2657 C CB . ALA B 1 139 ? 126.829 -10.978 37.527 1.00 25.22 ? 463 ALA B CB 1 ATOM 2658 N N . CYS B 1 140 ? 129.102 -13.127 38.098 1.00 24.71 ? 464 CYS B N 1 ATOM 2659 C CA . CYS B 1 140 ? 130.105 -14.010 37.549 1.00 25.39 ? 464 CYS B CA 1 ATOM 2660 C C . CYS B 1 140 ? 129.429 -15.149 36.817 1.00 23.61 ? 464 CYS B C 1 ATOM 2661 O O . CYS B 1 140 ? 128.555 -15.775 37.374 1.00 23.30 ? 464 CYS B O 1 ATOM 2662 C CB . CYS B 1 140 ? 130.933 -14.632 38.670 1.00 25.67 ? 464 CYS B CB 1 ATOM 2663 S SG . CYS B 1 140 ? 132.455 -15.331 38.086 1.00 29.41 ? 464 CYS B SG 1 ATOM 2664 N N . LEU B 1 141 ? 129.866 -15.423 35.595 1.00 22.76 ? 465 LEU B N 1 ATOM 2665 C CA . LEU B 1 141 ? 129.373 -16.555 34.817 1.00 22.18 ? 465 LEU B CA 1 ATOM 2666 C C . LEU B 1 141 ? 130.480 -17.584 34.745 1.00 20.13 ? 465 LEU B C 1 ATOM 2667 O O . LEU B 1 141 ? 131.578 -17.280 34.290 1.00 21.66 ? 465 LEU B O 1 ATOM 2668 C CB . LEU B 1 141 ? 128.987 -16.113 33.400 1.00 21.28 ? 465 LEU B CB 1 ATOM 2669 C CG . LEU B 1 141 ? 128.620 -17.180 32.374 1.00 22.01 ? 465 LEU B CG 1 ATOM 2670 C CD1 . LEU B 1 141 ? 127.512 -18.118 32.910 1.00 21.92 ? 465 LEU B CD1 1 ATOM 2671 C CD2 . LEU B 1 141 ? 128.185 -16.546 31.040 1.00 21.11 ? 465 LEU B CD2 1 ATOM 2672 N N . ILE B 1 142 ? 130.184 -18.791 35.204 1.00 19.68 ? 466 ILE B N 1 ATOM 2673 C CA . ILE B 1 142 ? 131.123 -19.906 35.191 1.00 20.18 ? 466 ILE B CA 1 ATOM 2674 C C . ILE B 1 142 ? 130.411 -21.040 34.458 1.00 20.71 ? 466 ILE B C 1 ATOM 2675 O O . ILE B 1 142 ? 129.344 -21.480 34.911 1.00 17.59 ? 466 ILE B O 1 ATOM 2676 C CB . ILE B 1 142 ? 131.463 -20.342 36.629 1.00 21.71 ? 466 ILE B CB 1 ATOM 2677 C CG1 . ILE B 1 142 ? 131.861 -19.131 37.476 1.00 22.27 ? 466 ILE B CG1 1 ATOM 2678 C CG2 . ILE B 1 142 ? 132.519 -21.420 36.662 1.00 18.81 ? 466 ILE B CG2 1 ATOM 2679 C CD1 . ILE B 1 142 ? 131.944 -19.423 38.967 1.00 22.76 ? 466 ILE B CD1 1 ATOM 2680 N N . GLN B 1 143 ? 130.977 -21.468 33.320 1.00 21.54 ? 467 GLN B N 1 ATOM 2681 C CA . GLN B 1 143 ? 130.281 -22.326 32.352 1.00 20.87 ? 467 GLN B CA 1 ATOM 2682 C C . GLN B 1 143 ? 131.154 -23.398 31.709 1.00 22.76 ? 467 GLN B C 1 ATOM 2683 O O . GLN B 1 143 ? 132.381 -23.324 31.755 1.00 23.12 ? 467 GLN B O 1 ATOM 2684 C CB . GLN B 1 143 ? 129.666 -21.477 31.258 1.00 21.15 ? 467 GLN B CB 1 ATOM 2685 C CG . GLN B 1 143 ? 130.663 -20.755 30.354 1.00 21.26 ? 467 GLN B CG 1 ATOM 2686 C CD . GLN B 1 143 ? 129.944 -19.973 29.283 1.00 20.39 ? 467 GLN B CD 1 ATOM 2687 O OE1 . GLN B 1 143 ? 128.785 -19.635 29.473 1.00 23.25 ? 467 GLN B OE1 1 ATOM 2688 N NE2 . GLN B 1 143 ? 130.596 -19.699 28.162 1.00 17.98 ? 467 GLN B NE2 1 ATOM 2689 N N . ASN B 1 144 ? 130.501 -24.402 31.124 1.00 23.87 ? 468 ASN B N 1 ATOM 2690 C CA . ASN B 1 144 ? 131.153 -25.490 30.395 1.00 23.92 ? 468 ASN B CA 1 ATOM 2691 C C . ASN B 1 144 ? 132.054 -26.386 31.241 1.00 24.61 ? 468 ASN B C 1 ATOM 2692 O O . ASN B 1 144 ? 132.993 -27.013 30.712 1.00 23.41 ? 468 ASN B O 1 ATOM 2693 C CB . ASN B 1 144 ? 131.928 -24.950 29.194 1.00 24.94 ? 468 ASN B CB 1 ATOM 2694 C CG . ASN B 1 144 ? 131.022 -24.292 28.167 1.00 26.45 ? 468 ASN B CG 1 ATOM 2695 O OD1 . ASN B 1 144 ? 129.805 -24.448 28.200 1.00 28.59 ? 468 ASN B OD1 1 ATOM 2696 N ND2 . ASN B 1 144 ? 131.613 -23.560 27.239 1.00 27.45 ? 468 ASN B ND2 1 ATOM 2697 N N . PHE B 1 145 ? 131.762 -26.472 32.542 1.00 23.45 ? 469 PHE B N 1 ATOM 2698 C CA . PHE B 1 145 ? 132.501 -27.386 33.398 1.00 22.51 ? 469 PHE B CA 1 ATOM 2699 C C . PHE B 1 145 ? 131.779 -28.714 33.552 1.00 24.85 ? 469 PHE B C 1 ATOM 2700 O O . PHE B 1 145 ? 130.549 -28.747 33.521 1.00 25.46 ? 469 PHE B O 1 ATOM 2701 C CB . PHE B 1 145 ? 132.814 -26.775 34.756 1.00 21.05 ? 469 PHE B CB 1 ATOM 2702 C CG . PHE B 1 145 ? 131.620 -26.315 35.516 1.00 18.77 ? 469 PHE B CG 1 ATOM 2703 C CD1 . PHE B 1 145 ? 130.974 -27.163 36.393 1.00 20.09 ? 469 PHE B CD1 1 ATOM 2704 C CD2 . PHE B 1 145 ? 131.156 -25.036 35.386 1.00 17.82 ? 469 PHE B CD2 1 ATOM 2705 C CE1 . PHE B 1 145 ? 129.865 -26.744 37.106 1.00 18.43 ? 469 PHE B CE1 1 ATOM 2706 C CE2 . PHE B 1 145 ? 130.049 -24.612 36.090 1.00 18.47 ? 469 PHE B CE2 1 ATOM 2707 C CZ . PHE B 1 145 ? 129.406 -25.465 36.954 1.00 18.51 ? 469 PHE B CZ 1 ATOM 2708 N N . MET B 1 146 ? 132.547 -29.805 33.657 1.00 24.76 ? 470 MET B N 1 ATOM 2709 C CA . MET B 1 146 ? 132.018 -31.073 34.171 1.00 25.59 ? 470 MET B CA 1 ATOM 2710 C C . MET B 1 146 ? 133.015 -31.807 35.097 1.00 23.92 ? 470 MET B C 1 ATOM 2711 O O . MET B 1 146 ? 134.219 -31.740 34.901 1.00 23.08 ? 470 MET B O 1 ATOM 2712 C CB . MET B 1 146 ? 131.454 -31.983 33.062 1.00 27.61 ? 470 MET B CB 1 ATOM 2713 C CG . MET B 1 146 ? 132.255 -32.067 31.778 1.00 31.65 ? 470 MET B CG 1 ATOM 2714 S SD . MET B 1 146 ? 131.365 -32.739 30.323 1.00 33.73 ? 470 MET B SD 1 ATOM 2715 C CE . MET B 1 146 ? 131.274 -34.475 30.766 1.00 34.01 ? 470 MET B CE 1 ATOM 2716 N N . PRO B 1 147 ? 132.513 -32.496 36.129 1.00 22.52 ? 471 PRO B N 1 ATOM 2717 C CA . PRO B 1 147 ? 131.114 -32.631 36.529 1.00 22.49 ? 471 PRO B CA 1 ATOM 2718 C C . PRO B 1 147 ? 130.566 -31.377 37.194 1.00 22.09 ? 471 PRO B C 1 ATOM 2719 O O . PRO B 1 147 ? 131.197 -30.323 37.184 1.00 19.39 ? 471 PRO B O 1 ATOM 2720 C CB . PRO B 1 147 ? 131.107 -33.813 37.504 1.00 23.27 ? 471 PRO B CB 1 ATOM 2721 C CG . PRO B 1 147 ? 132.497 -34.347 37.512 1.00 24.48 ? 471 PRO B CG 1 ATOM 2722 C CD . PRO B 1 147 ? 133.408 -33.291 36.977 1.00 23.60 ? 471 PRO B CD 1 ATOM 2723 N N . GLU B 1 148 ? 129.375 -31.502 37.749 1.00 23.83 ? 472 GLU B N 1 ATOM 2724 C CA . GLU B 1 148 ? 128.609 -30.337 38.150 1.00 27.67 ? 472 GLU B CA 1 ATOM 2725 C C . GLU B 1 148 ? 129.096 -29.727 39.479 1.00 27.36 ? 472 GLU B C 1 ATOM 2726 O O . GLU B 1 148 ? 128.687 -28.626 39.816 1.00 28.81 ? 472 GLU B O 1 ATOM 2727 C CB . GLU B 1 148 ? 127.124 -30.715 38.251 1.00 30.99 ? 472 GLU B CB 1 ATOM 2728 C CG . GLU B 1 148 ? 126.843 -31.644 39.417 1.00 34.74 ? 472 GLU B CG 1 ATOM 2729 C CD . GLU B 1 148 ? 125.468 -32.267 39.369 1.00 38.97 ? 472 GLU B CD 1 ATOM 2730 O OE1 . GLU B 1 148 ? 125.220 -33.072 38.431 1.00 41.71 ? 472 GLU B OE1 1 ATOM 2731 O OE2 . GLU B 1 148 ? 124.649 -31.966 40.283 1.00 42.10 ? 472 GLU B OE2 1 ATOM 2732 N N . ASP B 1 149 ? 129.947 -30.414 40.232 1.00 25.70 ? 473 ASP B N 1 ATOM 2733 C CA . ASP B 1 149 ? 130.398 -29.903 41.531 1.00 26.52 ? 473 ASP B CA 1 ATOM 2734 C C . ASP B 1 149 ? 131.294 -28.680 41.350 1.00 24.50 ? 473 ASP B C 1 ATOM 2735 O O . ASP B 1 149 ? 132.296 -28.731 40.630 1.00 24.99 ? 473 ASP B O 1 ATOM 2736 C CB . ASP B 1 149 ? 131.173 -30.969 42.324 1.00 27.70 ? 473 ASP B CB 1 ATOM 2737 C CG . ASP B 1 149 ? 130.267 -32.032 42.931 1.00 29.37 ? 473 ASP B CG 1 ATOM 2738 O OD1 . ASP B 1 149 ? 129.101 -32.133 42.513 1.00 30.73 ? 473 ASP B OD1 1 ATOM 2739 O OD2 . ASP B 1 149 ? 130.713 -32.769 43.833 1.00 31.11 ? 473 ASP B OD2 1 ATOM 2740 N N . ILE B 1 150 ? 130.942 -27.590 42.019 1.00 20.36 ? 474 ILE B N 1 ATOM 2741 C CA . ILE B 1 150 ? 131.716 -26.360 41.903 1.00 19.21 ? 474 ILE B CA 1 ATOM 2742 C C . ILE B 1 150 ? 131.548 -25.456 43.100 1.00 18.92 ? 474 ILE B C 1 ATOM 2743 O O . ILE B 1 150 ? 130.463 -25.317 43.636 1.00 18.98 ? 474 ILE B O 1 ATOM 2744 C CB . ILE B 1 150 ? 131.320 -25.556 40.663 1.00 19.57 ? 474 ILE B CB 1 ATOM 2745 C CG1 . ILE B 1 150 ? 132.398 -24.510 40.307 1.00 19.58 ? 474 ILE B CG1 1 ATOM 2746 C CG2 . ILE B 1 150 ? 129.938 -25.000 40.830 1.00 16.99 ? 474 ILE B CG2 1 ATOM 2747 C CD1 . ILE B 1 150 ? 132.834 -24.518 38.835 1.00 16.61 ? 474 ILE B CD1 1 ATOM 2748 N N . SER B 1 151 ? 132.629 -24.823 43.524 1.00 20.16 ? 475 SER B N 1 ATOM 2749 C CA . SER B 1 151 ? 132.513 -23.799 44.551 1.00 20.96 ? 475 SER B CA 1 ATOM 2750 C C . SER B 1 151 ? 132.869 -22.473 43.955 1.00 20.19 ? 475 SER B C 1 ATOM 2751 O O . SER B 1 151 ? 133.627 -22.412 43.014 1.00 19.97 ? 475 SER B O 1 ATOM 2752 C CB . SER B 1 151 ? 133.409 -24.095 45.755 1.00 19.13 ? 475 SER B CB 1 ATOM 2753 O OG . SER B 1 151 ? 132.967 -25.266 46.390 1.00 17.41 ? 475 SER B OG 1 ATOM 2754 N N . VAL B 1 152 ? 132.329 -21.404 44.508 1.00 22.49 ? 476 VAL B N 1 ATOM 2755 C CA . VAL B 1 152 ? 132.732 -20.084 44.062 1.00 24.53 ? 476 VAL B CA 1 ATOM 2756 C C . VAL B 1 152 ? 133.161 -19.241 45.237 1.00 27.78 ? 476 VAL B C 1 ATOM 2757 O O . VAL B 1 152 ? 132.468 -19.184 46.241 1.00 31.06 ? 476 VAL B O 1 ATOM 2758 C CB . VAL B 1 152 ? 131.573 -19.326 43.408 1.00 24.24 ? 476 VAL B CB 1 ATOM 2759 C CG1 . VAL B 1 152 ? 132.077 -17.970 42.946 1.00 23.74 ? 476 VAL B CG1 1 ATOM 2760 C CG2 . VAL B 1 152 ? 130.960 -20.126 42.251 1.00 21.42 ? 476 VAL B CG2 1 ATOM 2761 N N . GLN B 1 153 ? 134.295 -18.569 45.123 1.00 30.45 ? 477 GLN B N 1 ATOM 2762 C CA . GLN B 1 153 ? 134.689 -17.634 46.166 1.00 32.67 ? 477 GLN B CA 1 ATOM 2763 C C . GLN B 1 153 ? 135.005 -16.269 45.562 1.00 31.43 ? 477 GLN B C 1 ATOM 2764 O O . GLN B 1 153 ? 135.554 -16.188 44.467 1.00 33.12 ? 477 GLN B O 1 ATOM 2765 C CB . GLN B 1 153 ? 135.837 -18.205 47.023 1.00 34.50 ? 477 GLN B CB 1 ATOM 2766 C CG . GLN B 1 153 ? 137.099 -18.584 46.278 1.00 38.42 ? 477 GLN B CG 1 ATOM 2767 C CD . GLN B 1 153 ? 138.139 -19.277 47.183 1.00 40.78 ? 477 GLN B CD 1 ATOM 2768 O OE1 . GLN B 1 153 ? 139.360 -19.107 47.044 1.00 38.68 ? 477 GLN B OE1 1 ATOM 2769 N NE2 . GLN B 1 153 ? 137.635 -20.063 48.127 1.00 43.64 ? 477 GLN B NE2 1 ATOM 2770 N N . TRP B 1 154 ? 134.635 -15.197 46.254 1.00 29.56 ? 478 TRP B N 1 ATOM 2771 C CA . TRP B 1 154 ? 134.991 -13.865 45.805 1.00 28.85 ? 478 TRP B CA 1 ATOM 2772 C C . TRP B 1 154 ? 136.077 -13.290 46.669 1.00 26.89 ? 478 TRP B C 1 ATOM 2773 O O . TRP B 1 154 ? 135.996 -13.405 47.879 1.00 28.35 ? 478 TRP B O 1 ATOM 2774 C CB . TRP B 1 154 ? 133.800 -12.923 45.874 1.00 27.66 ? 478 TRP B CB 1 ATOM 2775 C CG . TRP B 1 154 ? 132.759 -13.212 44.876 1.00 26.47 ? 478 TRP B CG 1 ATOM 2776 C CD1 . TRP B 1 154 ? 131.795 -14.144 44.984 1.00 26.71 ? 478 TRP B CD1 1 ATOM 2777 C CD2 . TRP B 1 154 ? 132.556 -12.558 43.612 1.00 26.39 ? 478 TRP B CD2 1 ATOM 2778 N NE1 . TRP B 1 154 ? 131.004 -14.137 43.858 1.00 26.94 ? 478 TRP B NE1 1 ATOM 2779 C CE2 . TRP B 1 154 ? 131.453 -13.172 43.001 1.00 26.17 ? 478 TRP B CE2 1 ATOM 2780 C CE3 . TRP B 1 154 ? 133.202 -11.517 42.939 1.00 25.76 ? 478 TRP B CE3 1 ATOM 2781 C CZ2 . TRP B 1 154 ? 130.965 -12.774 41.758 1.00 27.25 ? 478 TRP B CZ2 1 ATOM 2782 C CZ3 . TRP B 1 154 ? 132.737 -11.137 41.704 1.00 26.58 ? 478 TRP B CZ3 1 ATOM 2783 C CH2 . TRP B 1 154 ? 131.621 -11.752 41.121 1.00 26.15 ? 478 TRP B CH2 1 ATOM 2784 N N . LEU B 1 155 ? 137.058 -12.637 46.053 1.00 25.67 ? 479 LEU B N 1 ATOM 2785 C CA . LEU B 1 155 ? 138.140 -12.009 46.794 1.00 26.78 ? 479 LEU B CA 1 ATOM 2786 C C . LEU B 1 155 ? 138.228 -10.480 46.630 1.00 27.08 ? 479 LEU B C 1 ATOM 2787 O O . LEU B 1 155 ? 138.067 -9.920 45.540 1.00 27.33 ? 479 LEU B O 1 ATOM 2788 C CB . LEU B 1 155 ? 139.462 -12.672 46.402 1.00 27.51 ? 479 LEU B CB 1 ATOM 2789 C CG . LEU B 1 155 ? 139.473 -14.178 46.707 1.00 29.03 ? 479 LEU B CG 1 ATOM 2790 C CD1 . LEU B 1 155 ? 138.948 -14.953 45.528 1.00 30.16 ? 479 LEU B CD1 1 ATOM 2791 C CD2 . LEU B 1 155 ? 140.860 -14.680 47.084 1.00 30.05 ? 479 LEU B CD2 1 ATOM 2792 N N . HIS B 1 156 ? 138.487 -9.812 47.744 1.00 27.33 ? 480 HIS B N 1 ATOM 2793 C CA . HIS B 1 156 ? 138.790 -8.392 47.747 1.00 28.13 ? 480 HIS B CA 1 ATOM 2794 C C . HIS B 1 156 ? 139.966 -8.188 48.684 1.00 27.63 ? 480 HIS B C 1 ATOM 2795 O O . HIS B 1 156 ? 139.987 -8.768 49.755 1.00 26.45 ? 480 HIS B O 1 ATOM 2796 C CB . HIS B 1 156 ? 137.564 -7.594 48.208 1.00 27.68 ? 480 HIS B CB 1 ATOM 2797 C CG . HIS B 1 156 ? 137.692 -6.120 47.998 1.00 28.52 ? 480 HIS B CG 1 ATOM 2798 N ND1 . HIS B 1 156 ? 137.412 -5.201 48.985 1.00 29.17 ? 480 HIS B ND1 1 ATOM 2799 C CD2 . HIS B 1 156 ? 138.089 -5.405 46.918 1.00 29.40 ? 480 HIS B CD2 1 ATOM 2800 C CE1 . HIS B 1 156 ? 137.627 -3.983 48.519 1.00 29.35 ? 480 HIS B CE1 1 ATOM 2801 N NE2 . HIS B 1 156 ? 138.030 -4.077 47.265 1.00 28.69 ? 480 HIS B NE2 1 ATOM 2802 N N . ASN B 1 157 ? 140.941 -7.384 48.272 1.00 30.46 ? 481 ASN B N 1 ATOM 2803 C CA . ASN B 1 157 ? 142.183 -7.191 49.030 1.00 33.17 ? 481 ASN B CA 1 ATOM 2804 C C . ASN B 1 157 ? 142.861 -8.517 49.312 1.00 33.40 ? 481 ASN B C 1 ATOM 2805 O O . ASN B 1 157 ? 143.349 -8.760 50.415 1.00 31.51 ? 481 ASN B O 1 ATOM 2806 C CB . ASN B 1 157 ? 141.937 -6.447 50.345 1.00 34.33 ? 481 ASN B CB 1 ATOM 2807 C CG . ASN B 1 157 ? 141.280 -5.105 50.129 1.00 36.02 ? 481 ASN B CG 1 ATOM 2808 O OD1 . ASN B 1 157 ? 141.565 -4.440 49.136 1.00 37.64 ? 481 ASN B OD1 1 ATOM 2809 N ND2 . ASN B 1 157 ? 140.395 -4.700 51.044 1.00 35.98 ? 481 ASN B ND2 1 ATOM 2810 N N . GLU B 1 158 ? 142.875 -9.365 48.293 1.00 35.29 ? 482 GLU B N 1 ATOM 2811 C CA . GLU B 1 158 ? 143.581 -10.631 48.368 1.00 37.20 ? 482 GLU B CA 1 ATOM 2812 C C . GLU B 1 158 ? 143.143 -11.427 49.599 1.00 35.45 ? 482 GLU B C 1 ATOM 2813 O O . GLU B 1 158 ? 143.938 -12.158 50.194 1.00 35.27 ? 482 GLU B O 1 ATOM 2814 C CB . GLU B 1 158 ? 145.092 -10.368 48.407 1.00 40.05 ? 482 GLU B CB 1 ATOM 2815 C CG . GLU B 1 158 ? 145.688 -9.843 47.090 1.00 42.68 ? 482 GLU B CG 1 ATOM 2816 C CD . GLU B 1 158 ? 145.656 -8.330 46.966 1.00 45.07 ? 482 GLU B CD 1 ATOM 2817 O OE1 . GLU B 1 158 ? 145.735 -7.633 47.999 1.00 47.00 ? 482 GLU B OE1 1 ATOM 2818 O OE2 . GLU B 1 158 ? 145.558 -7.826 45.826 1.00 47.79 ? 482 GLU B OE2 1 ATOM 2819 N N . VAL B 1 159 ? 141.881 -11.262 49.990 1.00 32.32 ? 483 VAL B N 1 ATOM 2820 C CA . VAL B 1 159 ? 141.284 -12.111 51.009 1.00 29.36 ? 483 VAL B CA 1 ATOM 2821 C C . VAL B 1 159 ? 139.887 -12.452 50.556 1.00 26.96 ? 483 VAL B C 1 ATOM 2822 O O . VAL B 1 159 ? 139.236 -11.699 49.852 1.00 24.05 ? 483 VAL B O 1 ATOM 2823 C CB . VAL B 1 159 ? 141.223 -11.447 52.413 1.00 29.77 ? 483 VAL B CB 1 ATOM 2824 C CG1 . VAL B 1 159 ? 142.629 -11.272 53.025 1.00 27.79 ? 483 VAL B CG1 1 ATOM 2825 C CG2 . VAL B 1 159 ? 140.490 -10.117 52.334 1.00 30.33 ? 483 VAL B CG2 1 ATOM 2826 N N . GLN B 1 160 ? 139.440 -13.623 50.970 1.00 27.01 ? 484 GLN B N 1 ATOM 2827 C CA . GLN B 1 160 ? 138.114 -14.101 50.661 1.00 26.94 ? 484 GLN B CA 1 ATOM 2828 C C . GLN B 1 160 ? 137.096 -13.315 51.469 1.00 25.24 ? 484 GLN B C 1 ATOM 2829 O O . GLN B 1 160 ? 137.271 -13.095 52.659 1.00 23.10 ? 484 GLN B O 1 ATOM 2830 C CB . GLN B 1 160 ? 138.052 -15.580 51.022 1.00 28.51 ? 484 GLN B CB 1 ATOM 2831 C CG . GLN B 1 160 ? 136.751 -16.237 50.731 1.00 30.59 ? 484 GLN B CG 1 ATOM 2832 C CD . GLN B 1 160 ? 136.844 -17.732 50.855 1.00 32.57 ? 484 GLN B CD 1 ATOM 2833 O OE1 . GLN B 1 160 ? 137.690 -18.363 50.199 1.00 37.52 ? 484 GLN B OE1 1 ATOM 2834 N NE2 . GLN B 1 160 ? 135.979 -18.312 51.672 1.00 31.31 ? 484 GLN B NE2 1 ATOM 2835 N N . LEU B 1 161 ? 136.034 -12.883 50.801 1.00 25.69 ? 485 LEU B N 1 ATOM 2836 C CA . LEU B 1 161 ? 134.898 -12.274 51.466 1.00 24.89 ? 485 LEU B CA 1 ATOM 2837 C C . LEU B 1 161 ? 134.048 -13.370 52.062 1.00 25.17 ? 485 LEU B C 1 ATOM 2838 O O . LEU B 1 161 ? 134.064 -14.493 51.585 1.00 25.58 ? 485 LEU B O 1 ATOM 2839 C CB . LEU B 1 161 ? 134.088 -11.459 50.463 1.00 26.05 ? 485 LEU B CB 1 ATOM 2840 C CG . LEU B 1 161 ? 134.733 -10.177 49.925 1.00 25.87 ? 485 LEU B CG 1 ATOM 2841 C CD1 . LEU B 1 161 ? 134.088 -9.763 48.615 1.00 25.25 ? 485 LEU B CD1 1 ATOM 2842 C CD2 . LEU B 1 161 ? 134.589 -9.079 50.985 1.00 24.15 ? 485 LEU B CD2 1 ATOM 2843 N N . PRO B 1 162 ? 133.304 -13.060 53.124 1.00 26.59 ? 486 PRO B N 1 ATOM 2844 C CA . PRO B 1 162 ? 132.435 -14.081 53.700 1.00 28.11 ? 486 PRO B CA 1 ATOM 2845 C C . PRO B 1 162 ? 131.498 -14.642 52.641 1.00 29.45 ? 486 PRO B C 1 ATOM 2846 O O . PRO B 1 162 ? 131.127 -13.926 51.717 1.00 30.32 ? 486 PRO B O 1 ATOM 2847 C CB . PRO B 1 162 ? 131.652 -13.324 54.783 1.00 28.54 ? 486 PRO B CB 1 ATOM 2848 C CG . PRO B 1 162 ? 132.519 -12.140 55.138 1.00 27.88 ? 486 PRO B CG 1 ATOM 2849 C CD . PRO B 1 162 ? 133.203 -11.770 53.819 1.00 27.36 ? 486 PRO B CD 1 ATOM 2850 N N . ASP B 1 163 ? 131.135 -15.912 52.765 1.00 32.08 ? 487 ASP B N 1 ATOM 2851 C CA . ASP B 1 163 ? 130.320 -16.587 51.763 1.00 34.29 ? 487 ASP B CA 1 ATOM 2852 C C . ASP B 1 163 ? 128.893 -16.059 51.744 1.00 31.36 ? 487 ASP B C 1 ATOM 2853 O O . ASP B 1 163 ? 128.276 -16.002 50.686 1.00 32.73 ? 487 ASP B O 1 ATOM 2854 C CB . ASP B 1 163 ? 130.311 -18.095 52.015 1.00 38.93 ? 487 ASP B CB 1 ATOM 2855 C CG . ASP B 1 163 ? 129.400 -18.470 53.141 1.00 43.83 ? 487 ASP B CG 1 ATOM 2856 O OD1 . ASP B 1 163 ? 129.364 -17.743 54.170 1.00 49.41 ? 487 ASP B OD1 1 ATOM 2857 O OD2 . ASP B 1 163 ? 128.704 -19.496 52.995 1.00 48.54 ? 487 ASP B OD2 1 ATOM 2858 N N . ALA B 1 164 ? 128.365 -15.674 52.899 1.00 28.86 ? 488 ALA B N 1 ATOM 2859 C CA . ALA B 1 164 ? 126.999 -15.154 52.988 1.00 29.28 ? 488 ALA B CA 1 ATOM 2860 C C . ALA B 1 164 ? 126.768 -13.948 52.072 1.00 29.92 ? 488 ALA B C 1 ATOM 2861 O O . ALA B 1 164 ? 125.628 -13.618 51.771 1.00 30.11 ? 488 ALA B O 1 ATOM 2862 C CB . ALA B 1 164 ? 126.678 -14.756 54.412 1.00 27.74 ? 488 ALA B CB 1 ATOM 2863 N N . ARG B 1 165 ? 127.849 -13.299 51.642 1.00 29.01 ? 489 ARG B N 1 ATOM 2864 C CA . ARG B 1 165 ? 127.779 -12.102 50.812 1.00 29.49 ? 489 ARG B CA 1 ATOM 2865 C C . ARG B 1 165 ? 127.522 -12.318 49.308 1.00 29.41 ? 489 ARG B C 1 ATOM 2866 O O . ARG B 1 165 ? 127.154 -11.395 48.577 1.00 28.47 ? 489 ARG B O 1 ATOM 2867 C CB . ARG B 1 165 ? 129.075 -11.334 50.999 1.00 30.47 ? 489 ARG B CB 1 ATOM 2868 C CG . ARG B 1 165 ? 128.977 -10.396 52.179 1.00 31.58 ? 489 ARG B CG 1 ATOM 2869 C CD . ARG B 1 165 ? 128.809 -8.994 51.660 1.00 32.36 ? 489 ARG B CD 1 ATOM 2870 N NE . ARG B 1 165 ? 130.090 -8.331 51.781 1.00 33.87 ? 489 ARG B NE 1 ATOM 2871 C CZ . ARG B 1 165 ? 130.542 -7.360 51.011 1.00 34.71 ? 489 ARG B CZ 1 ATOM 2872 N NH1 . ARG B 1 165 ? 129.833 -6.901 49.998 1.00 35.91 ? 489 ARG B NH1 1 ATOM 2873 N NH2 . ARG B 1 165 ? 131.735 -6.855 51.279 1.00 36.08 ? 489 ARG B NH2 1 ATOM 2874 N N . HIS B 1 166 ? 127.712 -13.537 48.829 1.00 28.92 ? 490 HIS B N 1 ATOM 2875 C CA . HIS B 1 166 ? 127.381 -13.818 47.455 1.00 28.91 ? 490 HIS B CA 1 ATOM 2876 C C . HIS B 1 166 ? 126.336 -14.941 47.414 1.00 29.40 ? 490 HIS B C 1 ATOM 2877 O O . HIS B 1 166 ? 126.172 -15.691 48.386 1.00 30.90 ? 490 HIS B O 1 ATOM 2878 C CB . HIS B 1 166 ? 128.661 -14.184 46.707 1.00 28.08 ? 490 HIS B CB 1 ATOM 2879 C CG . HIS B 1 166 ? 129.113 -15.584 46.964 1.00 28.73 ? 490 HIS B CG 1 ATOM 2880 N ND1 . HIS B 1 166 ? 130.146 -15.883 47.825 1.00 27.40 ? 490 HIS B ND1 1 ATOM 2881 C CD2 . HIS B 1 166 ? 128.644 -16.769 46.508 1.00 28.21 ? 490 HIS B CD2 1 ATOM 2882 C CE1 . HIS B 1 166 ? 130.302 -17.191 47.880 1.00 27.07 ? 490 HIS B CE1 1 ATOM 2883 N NE2 . HIS B 1 166 ? 129.405 -17.753 47.090 1.00 27.83 ? 490 HIS B NE2 1 ATOM 2884 N N . SER B 1 167 ? 125.608 -15.057 46.311 1.00 29.24 ? 491 SER B N 1 ATOM 2885 C CA . SER B 1 167 ? 124.817 -16.271 46.093 1.00 29.48 ? 491 SER B CA 1 ATOM 2886 C C . SER B 1 167 ? 125.172 -16.886 44.758 1.00 28.01 ? 491 SER B C 1 ATOM 2887 O O . SER B 1 167 ? 125.400 -16.189 43.770 1.00 28.95 ? 491 SER B O 1 ATOM 2888 C CB . SER B 1 167 ? 123.320 -15.998 46.127 1.00 28.96 ? 491 SER B CB 1 ATOM 2889 O OG . SER B 1 167 ? 123.077 -15.055 45.128 1.00 30.46 ? 491 SER B OG 1 ATOM 2890 N N . THR B 1 168 ? 125.209 -18.206 44.751 1.00 25.52 ? 492 THR B N 1 ATOM 2891 C CA . THR B 1 168 ? 125.458 -18.928 43.539 1.00 26.77 ? 492 THR B CA 1 ATOM 2892 C C . THR B 1 168 ? 124.238 -19.726 43.117 1.00 24.69 ? 492 THR B C 1 ATOM 2893 O O . THR B 1 168 ? 123.592 -20.342 43.951 1.00 24.51 ? 492 THR B O 1 ATOM 2894 C CB . THR B 1 168 ? 126.691 -19.810 43.698 1.00 26.36 ? 492 THR B CB 1 ATOM 2895 O OG1 . THR B 1 168 ? 127.799 -18.941 43.941 1.00 26.54 ? 492 THR B OG1 1 ATOM 2896 C CG2 . THR B 1 168 ? 126.947 -20.601 42.428 1.00 25.67 ? 492 THR B CG2 1 ATOM 2897 N N . THR B 1 169 ? 123.920 -19.713 41.824 1.00 25.34 ? 493 THR B N 1 ATOM 2898 C CA . THR B 1 169 ? 122.780 -20.514 41.323 1.00 26.17 ? 493 THR B CA 1 ATOM 2899 C C . THR B 1 169 ? 123.108 -22.017 41.330 1.00 27.60 ? 493 THR B C 1 ATOM 2900 O O . THR B 1 169 ? 124.269 -22.404 41.518 1.00 29.25 ? 493 THR B O 1 ATOM 2901 C CB . THR B 1 169 ? 122.326 -20.077 39.913 1.00 23.76 ? 493 THR B CB 1 ATOM 2902 O OG1 . THR B 1 169 ? 123.349 -20.378 38.966 1.00 24.39 ? 493 THR B OG1 1 ATOM 2903 C CG2 . THR B 1 169 ? 122.037 -18.617 39.876 1.00 20.72 ? 493 THR B CG2 1 ATOM 2904 N N . GLN B 1 170 ? 122.108 -22.874 41.151 1.00 28.95 ? 494 GLN B N 1 ATOM 2905 C CA . GLN B 1 170 ? 122.396 -24.311 41.135 1.00 31.58 ? 494 GLN B CA 1 ATOM 2906 C C . GLN B 1 170 ? 122.874 -24.729 39.733 1.00 29.33 ? 494 GLN B C 1 ATOM 2907 O O . GLN B 1 170 ? 122.445 -24.178 38.715 1.00 26.38 ? 494 GLN B O 1 ATOM 2908 C CB . GLN B 1 170 ? 121.205 -25.154 41.627 1.00 34.42 ? 494 GLN B CB 1 ATOM 2909 C CG . GLN B 1 170 ? 120.841 -24.963 43.139 1.00 38.71 ? 494 GLN B CG 1 ATOM 2910 C CD . GLN B 1 170 ? 121.728 -25.733 44.160 1.00 41.79 ? 494 GLN B CD 1 ATOM 2911 O OE1 . GLN B 1 170 ? 122.134 -26.878 43.927 1.00 44.05 ? 494 GLN B OE1 1 ATOM 2912 N NE2 . GLN B 1 170 ? 122.002 -25.101 45.310 1.00 44.97 ? 494 GLN B NE2 1 ATOM 2913 N N . PRO B 1 171 ? 123.791 -25.696 39.671 1.00 29.28 ? 495 PRO B N 1 ATOM 2914 C CA . PRO B 1 171 ? 124.290 -26.056 38.343 1.00 29.44 ? 495 PRO B CA 1 ATOM 2915 C C . PRO B 1 171 ? 123.178 -26.461 37.383 1.00 29.07 ? 495 PRO B C 1 ATOM 2916 O O . PRO B 1 171 ? 122.280 -27.220 37.748 1.00 28.54 ? 495 PRO B O 1 ATOM 2917 C CB . PRO B 1 171 ? 125.228 -27.241 38.626 1.00 28.70 ? 495 PRO B CB 1 ATOM 2918 C CG . PRO B 1 171 ? 125.664 -27.047 40.047 1.00 28.67 ? 495 PRO B CG 1 ATOM 2919 C CD . PRO B 1 171 ? 124.498 -26.415 40.753 1.00 28.80 ? 495 PRO B CD 1 ATOM 2920 N N . ARG B 1 172 ? 123.269 -25.952 36.160 1.00 29.51 ? 496 ARG B N 1 ATOM 2921 C CA . ARG B 1 172 ? 122.351 -26.300 35.082 1.00 31.16 ? 496 ARG B CA 1 ATOM 2922 C C . ARG B 1 172 ? 123.115 -26.783 33.850 1.00 32.11 ? 496 ARG B C 1 ATOM 2923 O O . ARG B 1 172 ? 124.244 -26.380 33.587 1.00 30.55 ? 496 ARG B O 1 ATOM 2924 C CB . ARG B 1 172 ? 121.520 -25.088 34.692 1.00 32.12 ? 496 ARG B CB 1 ATOM 2925 C CG . ARG B 1 172 ? 120.446 -24.726 35.697 1.00 34.03 ? 496 ARG B CG 1 ATOM 2926 C CD . ARG B 1 172 ? 119.861 -23.342 35.425 1.00 36.20 ? 496 ARG B CD 1 ATOM 2927 N NE . ARG B 1 172 ? 118.468 -23.290 35.868 1.00 39.95 ? 496 ARG B NE 1 ATOM 2928 C CZ . ARG B 1 172 ? 117.399 -23.659 35.154 1.00 40.89 ? 496 ARG B CZ 1 ATOM 2929 N NH1 . ARG B 1 172 ? 117.493 -24.113 33.913 1.00 40.45 ? 496 ARG B NH1 1 ATOM 2930 N NH2 . ARG B 1 172 ? 116.196 -23.561 35.699 1.00 43.41 ? 496 ARG B NH2 1 ATOM 2931 N N . LYS B 1 173 ? 122.509 -27.672 33.082 1.00 33.96 ? 497 LYS B N 1 ATOM 2932 C CA . LYS B 1 173 ? 123.174 -28.129 31.886 1.00 36.12 ? 497 LYS B CA 1 ATOM 2933 C C . LYS B 1 173 ? 123.195 -26.972 30.909 1.00 36.66 ? 497 LYS B C 1 ATOM 2934 O O . LYS B 1 173 ? 122.225 -26.238 30.808 1.00 36.28 ? 497 LYS B O 1 ATOM 2935 C CB . LYS B 1 173 ? 122.484 -29.367 31.313 1.00 37.91 ? 497 LYS B CB 1 ATOM 2936 C CG . LYS B 1 173 ? 122.860 -30.618 32.104 1.00 40.65 ? 497 LYS B CG 1 ATOM 2937 C CD . LYS B 1 173 ? 122.792 -31.885 31.260 1.00 42.47 ? 497 LYS B CD 1 ATOM 2938 C CE . LYS B 1 173 ? 123.693 -32.999 31.798 1.00 43.23 ? 497 LYS B CE 1 ATOM 2939 N NZ . LYS B 1 173 ? 123.141 -34.352 31.436 1.00 43.60 ? 497 LYS B NZ 1 ATOM 2940 N N . THR B 1 174 ? 124.329 -26.794 30.240 1.00 38.11 ? 498 THR B N 1 ATOM 2941 C CA . THR B 1 174 ? 124.445 -25.999 29.013 1.00 38.92 ? 498 THR B CA 1 ATOM 2942 C C . THR B 1 174 ? 123.864 -26.796 27.849 1.00 40.16 ? 498 THR B C 1 ATOM 2943 O O . THR B 1 174 ? 123.525 -27.973 27.993 1.00 38.78 ? 498 THR B O 1 ATOM 2944 C CB . THR B 1 174 ? 125.927 -25.728 28.657 1.00 39.30 ? 498 THR B CB 1 ATOM 2945 O OG1 . THR B 1 174 ? 126.541 -26.954 28.236 1.00 39.47 ? 498 THR B OG1 1 ATOM 2946 C CG2 . THR B 1 174 ? 126.724 -25.161 29.851 1.00 38.69 ? 498 THR B CG2 1 ATOM 2947 N N . LYS B 1 175 ? 123.760 -26.161 26.685 1.00 43.33 ? 499 LYS B N 1 ATOM 2948 C CA . LYS B 1 175 ? 123.233 -26.843 25.492 1.00 44.73 ? 499 LYS B CA 1 ATOM 2949 C C . LYS B 1 175 ? 124.187 -27.960 25.074 1.00 44.56 ? 499 LYS B C 1 ATOM 2950 O O . LYS B 1 175 ? 123.766 -28.922 24.431 1.00 44.51 ? 499 LYS B O 1 ATOM 2951 C CB . LYS B 1 175 ? 123.030 -25.884 24.313 1.00 46.56 ? 499 LYS B CB 1 ATOM 2952 C CG . LYS B 1 175 ? 122.130 -24.670 24.591 1.00 48.67 ? 499 LYS B CG 1 ATOM 2953 C CD . LYS B 1 175 ? 120.669 -24.888 24.238 1.00 49.74 ? 499 LYS B CD 1 ATOM 2954 C CE . LYS B 1 175 ? 120.490 -25.058 22.731 1.00 51.77 ? 499 LYS B CE 1 ATOM 2955 N NZ . LYS B 1 175 ? 121.258 -24.066 21.896 1.00 53.28 ? 499 LYS B NZ 1 ATOM 2956 N N . GLY B 1 176 ? 125.464 -27.820 25.434 1.00 44.33 ? 500 GLY B N 1 ATOM 2957 C CA . GLY B 1 176 ? 126.432 -28.913 25.318 1.00 44.19 ? 500 GLY B CA 1 ATOM 2958 C C . GLY B 1 176 ? 126.230 -29.970 26.396 1.00 43.89 ? 500 GLY B C 1 ATOM 2959 O O . GLY B 1 176 ? 125.097 -30.294 26.779 1.00 45.37 ? 500 GLY B O 1 ATOM 2960 N N . SER B 1 177 ? 127.331 -30.517 26.894 1.00 41.41 ? 501 SER B N 1 ATOM 2961 C CA . SER B 1 177 ? 127.262 -31.535 27.937 1.00 39.64 ? 501 SER B CA 1 ATOM 2962 C C . SER B 1 177 ? 127.733 -30.981 29.273 1.00 37.19 ? 501 SER B C 1 ATOM 2963 O O . SER B 1 177 ? 127.646 -31.677 30.276 1.00 40.07 ? 501 SER B O 1 ATOM 2964 C CB . SER B 1 177 ? 128.105 -32.757 27.569 1.00 39.95 ? 501 SER B CB 1 ATOM 2965 O OG . SER B 1 177 ? 127.572 -33.400 26.423 1.00 39.99 ? 501 SER B OG 1 ATOM 2966 N N . GLY B 1 178 ? 128.220 -29.741 29.277 1.00 32.49 ? 502 GLY B N 1 ATOM 2967 C CA . GLY B 1 178 ? 128.738 -29.110 30.479 1.00 29.93 ? 502 GLY B CA 1 ATOM 2968 C C . GLY B 1 178 ? 127.689 -28.345 31.251 1.00 26.43 ? 502 GLY B C 1 ATOM 2969 O O . GLY B 1 178 ? 126.550 -28.288 30.824 1.00 26.27 ? 502 GLY B O 1 ATOM 2970 N N . PHE B 1 179 ? 128.091 -27.776 32.385 1.00 23.50 ? 503 PHE B N 1 ATOM 2971 C CA . PHE B 1 179 ? 127.196 -27.085 33.304 1.00 21.68 ? 503 PHE B CA 1 ATOM 2972 C C . PHE B 1 179 ? 127.571 -25.607 33.432 1.00 22.14 ? 503 PHE B C 1 ATOM 2973 O O . PHE B 1 179 ? 128.693 -25.177 33.085 1.00 21.18 ? 503 PHE B O 1 ATOM 2974 C CB . PHE B 1 179 ? 127.234 -27.742 34.682 1.00 21.26 ? 503 PHE B CB 1 ATOM 2975 C CG . PHE B 1 179 ? 126.776 -29.170 34.691 1.00 20.23 ? 503 PHE B CG 1 ATOM 2976 C CD1 . PHE B 1 179 ? 127.668 -30.200 34.451 1.00 21.05 ? 503 PHE B CD1 1 ATOM 2977 C CD2 . PHE B 1 179 ? 125.467 -29.487 34.938 1.00 21.31 ? 503 PHE B CD2 1 ATOM 2978 C CE1 . PHE B 1 179 ? 127.250 -31.524 34.443 1.00 20.87 ? 503 PHE B CE1 1 ATOM 2979 C CE2 . PHE B 1 179 ? 125.044 -30.830 34.930 1.00 22.31 ? 503 PHE B CE2 1 ATOM 2980 C CZ . PHE B 1 179 ? 125.947 -31.836 34.686 1.00 20.43 ? 503 PHE B CZ 1 ATOM 2981 N N . PHE B 1 180 ? 126.629 -24.812 33.927 1.00 21.01 ? 504 PHE B N 1 ATOM 2982 C CA . PHE B 1 180 ? 126.954 -23.435 34.305 1.00 20.41 ? 504 PHE B CA 1 ATOM 2983 C C . PHE B 1 180 ? 126.241 -23.049 35.597 1.00 19.91 ? 504 PHE B C 1 ATOM 2984 O O . PHE B 1 180 ? 125.174 -23.591 35.905 1.00 20.31 ? 504 PHE B O 1 ATOM 2985 C CB . PHE B 1 180 ? 126.551 -22.464 33.197 1.00 19.58 ? 504 PHE B CB 1 ATOM 2986 C CG . PHE B 1 180 ? 125.062 -22.288 33.069 1.00 18.63 ? 504 PHE B CG 1 ATOM 2987 C CD1 . PHE B 1 180 ? 124.404 -21.305 33.799 1.00 16.84 ? 504 PHE B CD1 1 ATOM 2988 C CD2 . PHE B 1 180 ? 124.316 -23.096 32.225 1.00 17.73 ? 504 PHE B CD2 1 ATOM 2989 C CE1 . PHE B 1 180 ? 123.018 -21.132 33.694 1.00 15.52 ? 504 PHE B CE1 1 ATOM 2990 C CE2 . PHE B 1 180 ? 122.911 -22.915 32.103 1.00 16.61 ? 504 PHE B CE2 1 ATOM 2991 C CZ . PHE B 1 180 ? 122.278 -21.940 32.859 1.00 14.85 ? 504 PHE B CZ 1 ATOM 2992 N N . VAL B 1 181 ? 126.860 -22.126 36.334 1.00 19.37 ? 505 VAL B N 1 ATOM 2993 C CA . VAL B 1 181 ? 126.253 -21.401 37.435 1.00 18.19 ? 505 VAL B CA 1 ATOM 2994 C C . VAL B 1 181 ? 126.513 -19.926 37.259 1.00 19.40 ? 505 VAL B C 1 ATOM 2995 O O . VAL B 1 181 ? 127.467 -19.545 36.587 1.00 19.56 ? 505 VAL B O 1 ATOM 2996 C CB . VAL B 1 181 ? 126.802 -21.835 38.798 1.00 19.58 ? 505 VAL B CB 1 ATOM 2997 C CG1 . VAL B 1 181 ? 126.428 -23.294 39.059 1.00 21.44 ? 505 VAL B CG1 1 ATOM 2998 C CG2 . VAL B 1 181 ? 128.315 -21.605 38.906 1.00 17.41 ? 505 VAL B CG2 1 ATOM 2999 N N . PHE B 1 182 ? 125.652 -19.084 37.827 1.00 21.24 ? 506 PHE B N 1 ATOM 3000 C CA . PHE B 1 182 ? 125.978 -17.670 37.972 1.00 21.98 ? 506 PHE B CA 1 ATOM 3001 C C . PHE B 1 182 ? 126.166 -17.369 39.452 1.00 22.69 ? 506 PHE B C 1 ATOM 3002 O O . PHE B 1 182 ? 125.476 -17.938 40.306 1.00 26.64 ? 506 PHE B O 1 ATOM 3003 C CB . PHE B 1 182 ? 124.848 -16.774 37.495 1.00 22.67 ? 506 PHE B CB 1 ATOM 3004 C CG . PHE B 1 182 ? 124.655 -16.718 36.008 1.00 23.43 ? 506 PHE B CG 1 ATOM 3005 C CD1 . PHE B 1 182 ? 123.743 -17.561 35.364 1.00 23.90 ? 506 PHE B CD1 1 ATOM 3006 C CD2 . PHE B 1 182 ? 125.309 -15.764 35.261 1.00 22.91 ? 506 PHE B CD2 1 ATOM 3007 C CE1 . PHE B 1 182 ? 123.553 -17.493 33.985 1.00 22.10 ? 506 PHE B CE1 1 ATOM 3008 C CE2 . PHE B 1 182 ? 125.110 -15.666 33.882 1.00 22.20 ? 506 PHE B CE2 1 ATOM 3009 C CZ . PHE B 1 182 ? 124.233 -16.529 33.250 1.00 22.66 ? 506 PHE B CZ 1 ATOM 3010 N N . SER B 1 183 ? 127.079 -16.456 39.747 1.00 21.31 ? 507 SER B N 1 ATOM 3011 C CA . SER B 1 183 ? 127.248 -15.923 41.077 1.00 22.41 ? 507 SER B CA 1 ATOM 3012 C C . SER B 1 183 ? 127.074 -14.405 41.089 1.00 23.50 ? 507 SER B C 1 ATOM 3013 O O . SER B 1 183 ? 127.582 -13.681 40.230 1.00 22.02 ? 507 SER B O 1 ATOM 3014 C CB . SER B 1 183 ? 128.656 -16.244 41.553 1.00 23.78 ? 507 SER B CB 1 ATOM 3015 O OG . SER B 1 183 ? 128.809 -15.988 42.927 1.00 24.14 ? 507 SER B OG 1 ATOM 3016 N N . ARG B 1 184 ? 126.361 -13.948 42.105 1.00 24.59 ? 508 ARG B N 1 ATOM 3017 C CA . ARG B 1 184 ? 125.982 -12.571 42.293 1.00 23.96 ? 508 ARG B CA 1 ATOM 3018 C C . ARG B 1 184 ? 126.563 -12.044 43.604 1.00 24.62 ? 508 ARG B C 1 ATOM 3019 O O . ARG B 1 184 ? 126.509 -12.697 44.640 1.00 22.69 ? 508 ARG B O 1 ATOM 3020 C CB . ARG B 1 184 ? 124.478 -12.546 42.390 1.00 25.99 ? 508 ARG B CB 1 ATOM 3021 C CG . ARG B 1 184 ? 123.860 -11.185 42.580 1.00 28.43 ? 508 ARG B CG 1 ATOM 3022 C CD . ARG B 1 184 ? 122.341 -11.334 42.580 1.00 30.71 ? 508 ARG B CD 1 ATOM 3023 N NE . ARG B 1 184 ? 121.724 -10.048 42.832 1.00 33.53 ? 508 ARG B NE 1 ATOM 3024 C CZ . ARG B 1 184 ? 121.552 -9.534 44.040 1.00 35.58 ? 508 ARG B CZ 1 ATOM 3025 N NH1 . ARG B 1 184 ? 121.927 -10.232 45.104 1.00 36.56 ? 508 ARG B NH1 1 ATOM 3026 N NH2 . ARG B 1 184 ? 121.001 -8.330 44.175 1.00 36.62 ? 508 ARG B NH2 1 ATOM 3027 N N . LEU B 1 185 ? 127.136 -10.852 43.559 1.00 26.77 ? 509 LEU B N 1 ATOM 3028 C CA . LEU B 1 185 ? 127.711 -10.234 44.750 1.00 27.75 ? 509 LEU B CA 1 ATOM 3029 C C . LEU B 1 185 ? 127.500 -8.735 44.683 1.00 28.63 ? 509 LEU B C 1 ATOM 3030 O O . LEU B 1 185 ? 128.023 -8.095 43.766 1.00 30.55 ? 509 LEU B O 1 ATOM 3031 C CB . LEU B 1 185 ? 129.200 -10.503 44.813 1.00 27.07 ? 509 LEU B CB 1 ATOM 3032 C CG . LEU B 1 185 ? 130.040 -9.771 45.868 1.00 28.89 ? 509 LEU B CG 1 ATOM 3033 C CD1 . LEU B 1 185 ? 129.713 -10.163 47.335 1.00 26.33 ? 509 LEU B CD1 1 ATOM 3034 C CD2 . LEU B 1 185 ? 131.547 -9.989 45.561 1.00 27.30 ? 509 LEU B CD2 1 ATOM 3035 N N . GLU B 1 186 ? 126.745 -8.198 45.638 1.00 29.12 ? 510 GLU B N 1 ATOM 3036 C CA . GLU B 1 186 ? 126.603 -6.750 45.834 1.00 31.92 ? 510 GLU B CA 1 ATOM 3037 C C . GLU B 1 186 ? 127.820 -6.144 46.562 1.00 32.11 ? 510 GLU B C 1 ATOM 3038 O O . GLU B 1 186 ? 128.228 -6.630 47.612 1.00 30.49 ? 510 GLU B O 1 ATOM 3039 C CB . GLU B 1 186 ? 125.342 -6.460 46.662 1.00 34.78 ? 510 GLU B CB 1 ATOM 3040 C CG . GLU B 1 186 ? 124.034 -7.041 46.085 1.00 38.23 ? 510 GLU B CG 1 ATOM 3041 C CD . GLU B 1 186 ? 122.789 -6.658 46.901 1.00 41.70 ? 510 GLU B CD 1 ATOM 3042 O OE1 . GLU B 1 186 ? 121.980 -7.575 47.244 1.00 41.42 ? 510 GLU B OE1 1 ATOM 3043 O OE2 . GLU B 1 186 ? 122.646 -5.436 47.188 1.00 42.54 ? 510 GLU B OE2 1 ATOM 3044 N N . VAL B 1 187 ? 128.389 -5.075 46.010 1.00 32.39 ? 511 VAL B N 1 ATOM 3045 C CA . VAL B 1 187 ? 129.489 -4.387 46.657 1.00 32.37 ? 511 VAL B CA 1 ATOM 3046 C C . VAL B 1 187 ? 129.167 -2.933 46.971 1.00 33.69 ? 511 VAL B C 1 ATOM 3047 O O . VAL B 1 187 ? 128.174 -2.388 46.467 1.00 34.56 ? 511 VAL B O 1 ATOM 3048 C CB . VAL B 1 187 ? 130.761 -4.452 45.794 1.00 32.26 ? 511 VAL B CB 1 ATOM 3049 C CG1 . VAL B 1 187 ? 131.150 -5.902 45.566 1.00 31.72 ? 511 VAL B CG1 1 ATOM 3050 C CG2 . VAL B 1 187 ? 130.578 -3.686 44.473 1.00 31.58 ? 511 VAL B CG2 1 ATOM 3051 N N . THR B 1 188 ? 130.029 -2.312 47.782 1.00 33.59 ? 512 THR B N 1 ATOM 3052 C CA . THR B 1 188 ? 129.811 -0.946 48.304 1.00 33.02 ? 512 THR B CA 1 ATOM 3053 C C . THR B 1 188 ? 130.881 -0.005 47.772 1.00 33.66 ? 512 THR B C 1 ATOM 3054 O O . THR B 1 188 ? 131.994 -0.446 47.486 1.00 33.94 ? 512 THR B O 1 ATOM 3055 C CB . THR B 1 188 ? 129.884 -0.899 49.859 1.00 32.05 ? 512 THR B CB 1 ATOM 3056 O OG1 . THR B 1 188 ? 131.225 -1.170 50.297 1.00 31.59 ? 512 THR B OG1 1 ATOM 3057 C CG2 . THR B 1 188 ? 128.941 -1.914 50.489 1.00 31.67 ? 512 THR B CG2 1 ATOM 3058 N N . ARG B 1 189 ? 130.559 1.283 47.653 1.00 34.92 ? 513 ARG B N 1 ATOM 3059 C CA . ARG B 1 189 ? 131.540 2.265 47.194 1.00 35.50 ? 513 ARG B CA 1 ATOM 3060 C C . ARG B 1 189 ? 132.797 2.171 48.062 1.00 34.98 ? 513 ARG B C 1 ATOM 3061 O O . ARG B 1 189 ? 133.913 2.078 47.534 1.00 33.35 ? 513 ARG B O 1 ATOM 3062 C CB . ARG B 1 189 ? 130.961 3.689 47.187 1.00 37.40 ? 513 ARG B CB 1 ATOM 3063 C CG . ARG B 1 189 ? 132.007 4.822 47.059 1.00 39.32 ? 513 ARG B CG 1 ATOM 3064 C CD . ARG B 1 189 ? 131.426 6.205 46.658 1.00 40.69 ? 513 ARG B CD 1 ATOM 3065 N NE . ARG B 1 189 ? 131.141 6.288 45.221 1.00 41.19 ? 513 ARG B NE 1 ATOM 3066 C CZ . ARG B 1 189 ? 129.928 6.469 44.713 1.00 41.89 ? 513 ARG B CZ 1 ATOM 3067 N NH1 . ARG B 1 189 ? 128.891 6.614 45.528 1.00 42.26 ? 513 ARG B NH1 1 ATOM 3068 N NH2 . ARG B 1 189 ? 129.751 6.507 43.395 1.00 42.05 ? 513 ARG B NH2 1 ATOM 3069 N N . ALA B 1 190 ? 132.623 2.176 49.385 1.00 33.82 ? 514 ALA B N 1 ATOM 3070 C CA . ALA B 1 190 ? 133.772 2.094 50.286 1.00 33.72 ? 514 ALA B CA 1 ATOM 3071 C C . ALA B 1 190 ? 134.759 1.031 49.807 1.00 34.19 ? 514 ALA B C 1 ATOM 3072 O O . ALA B 1 190 ? 135.972 1.181 49.963 1.00 33.24 ? 514 ALA B O 1 ATOM 3073 C CB . ALA B 1 190 ? 133.327 1.798 51.702 1.00 32.41 ? 514 ALA B CB 1 ATOM 3074 N N . GLU B 1 191 ? 134.245 -0.044 49.215 1.00 35.21 ? 515 GLU B N 1 ATOM 3075 C CA . GLU B 1 191 ? 135.112 -1.156 48.841 1.00 36.02 ? 515 GLU B CA 1 ATOM 3076 C C . GLU B 1 191 ? 135.865 -0.931 47.543 1.00 35.56 ? 515 GLU B C 1 ATOM 3077 O O . GLU B 1 191 ? 137.091 -1.104 47.475 1.00 34.39 ? 515 GLU B O 1 ATOM 3078 C CB . GLU B 1 191 ? 134.307 -2.444 48.779 1.00 37.03 ? 515 GLU B CB 1 ATOM 3079 C CG . GLU B 1 191 ? 133.809 -2.846 50.149 1.00 38.01 ? 515 GLU B CG 1 ATOM 3080 C CD . GLU B 1 191 ? 132.892 -4.057 50.146 1.00 38.95 ? 515 GLU B CD 1 ATOM 3081 O OE1 . GLU B 1 191 ? 133.163 -4.970 50.954 1.00 38.55 ? 515 GLU B OE1 1 ATOM 3082 O OE2 . GLU B 1 191 ? 131.911 -4.097 49.364 1.00 38.69 ? 515 GLU B OE2 1 ATOM 3083 N N . TRP B 1 192 ? 135.133 -0.540 46.511 1.00 35.10 ? 516 TRP B N 1 ATOM 3084 C CA . TRP B 1 192 ? 135.769 -0.365 45.230 1.00 36.26 ? 516 TRP B CA 1 ATOM 3085 C C . TRP B 1 192 ? 136.680 0.862 45.235 1.00 37.99 ? 516 TRP B C 1 ATOM 3086 O O . TRP B 1 192 ? 137.614 0.948 44.444 1.00 38.18 ? 516 TRP B O 1 ATOM 3087 C CB . TRP B 1 192 ? 134.730 -0.360 44.103 1.00 36.10 ? 516 TRP B CB 1 ATOM 3088 C CG . TRP B 1 192 ? 133.866 0.889 43.910 1.00 36.48 ? 516 TRP B CG 1 ATOM 3089 C CD1 . TRP B 1 192 ? 134.279 2.106 43.449 1.00 37.16 ? 516 TRP B CD1 1 ATOM 3090 C CD2 . TRP B 1 192 ? 132.447 1.006 44.113 1.00 35.12 ? 516 TRP B CD2 1 ATOM 3091 N NE1 . TRP B 1 192 ? 133.217 2.976 43.375 1.00 36.74 ? 516 TRP B NE1 1 ATOM 3092 C CE2 . TRP B 1 192 ? 132.081 2.321 43.775 1.00 36.27 ? 516 TRP B CE2 1 ATOM 3093 C CE3 . TRP B 1 192 ? 131.455 0.132 44.563 1.00 35.12 ? 516 TRP B CE3 1 ATOM 3094 C CZ2 . TRP B 1 192 ? 130.758 2.783 43.875 1.00 36.67 ? 516 TRP B CZ2 1 ATOM 3095 C CZ3 . TRP B 1 192 ? 130.144 0.585 44.653 1.00 35.05 ? 516 TRP B CZ3 1 ATOM 3096 C CH2 . TRP B 1 192 ? 129.808 1.898 44.312 1.00 35.51 ? 516 TRP B CH2 1 ATOM 3097 N N . GLU B 1 193 ? 136.422 1.808 46.131 1.00 40.56 ? 517 GLU B N 1 ATOM 3098 C CA . GLU B 1 193 ? 137.233 3.032 46.195 1.00 42.41 ? 517 GLU B CA 1 ATOM 3099 C C . GLU B 1 193 ? 138.526 2.742 46.943 1.00 42.12 ? 517 GLU B C 1 ATOM 3100 O O . GLU B 1 193 ? 139.588 3.276 46.623 1.00 42.01 ? 517 GLU B O 1 ATOM 3101 C CB . GLU B 1 193 ? 136.490 4.158 46.924 1.00 43.83 ? 517 GLU B CB 1 ATOM 3102 C CG . GLU B 1 193 ? 135.209 4.639 46.254 1.00 45.24 ? 517 GLU B CG 1 ATOM 3103 C CD . GLU B 1 193 ? 135.233 6.101 45.787 1.00 46.18 ? 517 GLU B CD 1 ATOM 3104 O OE1 . GLU B 1 193 ? 136.237 6.575 45.201 1.00 48.00 ? 517 GLU B OE1 1 ATOM 3105 O OE2 . GLU B 1 193 ? 134.206 6.778 45.996 1.00 45.66 ? 517 GLU B OE2 1 ATOM 3106 N N . GLN B 1 194 ? 138.416 1.899 47.962 1.00 41.23 ? 518 GLN B N 1 ATOM 3107 C CA . GLN B 1 194 ? 139.579 1.446 48.695 1.00 40.80 ? 518 GLN B CA 1 ATOM 3108 C C . GLN B 1 194 ? 140.445 0.566 47.801 1.00 39.56 ? 518 GLN B C 1 ATOM 3109 O O . GLN B 1 194 ? 141.680 0.634 47.852 1.00 37.66 ? 518 GLN B O 1 ATOM 3110 C CB . GLN B 1 194 ? 139.134 0.678 49.935 1.00 42.56 ? 518 GLN B CB 1 ATOM 3111 C CG . GLN B 1 194 ? 140.271 0.314 50.893 1.00 44.69 ? 518 GLN B CG 1 ATOM 3112 C CD . GLN B 1 194 ? 140.741 -1.134 50.757 1.00 45.98 ? 518 GLN B CD 1 ATOM 3113 O OE1 . GLN B 1 194 ? 139.946 -2.041 50.488 1.00 47.23 ? 518 GLN B OE1 1 ATOM 3114 N NE2 . GLN B 1 194 ? 142.042 -1.355 50.963 1.00 46.85 ? 518 GLN B NE2 1 ATOM 3115 N N . LYS B 1 195 ? 139.787 -0.254 46.980 1.00 39.17 ? 519 LYS B N 1 ATOM 3116 C CA . LYS B 1 195 ? 140.484 -1.073 45.987 1.00 38.15 ? 519 LYS B CA 1 ATOM 3117 C C . LYS B 1 195 ? 139.520 -1.569 44.915 1.00 36.78 ? 519 LYS B C 1 ATOM 3118 O O . LYS B 1 195 ? 138.675 -2.402 45.202 1.00 34.54 ? 519 LYS B O 1 ATOM 3119 C CB . LYS B 1 195 ? 141.159 -2.258 46.671 1.00 37.42 ? 519 LYS B CB 1 ATOM 3120 C CG . LYS B 1 195 ? 142.632 -2.399 46.363 1.00 37.99 ? 519 LYS B CG 1 ATOM 3121 C CD . LYS B 1 195 ? 142.889 -3.274 45.160 1.00 39.04 ? 519 LYS B CD 1 ATOM 3122 C CE . LYS B 1 195 ? 144.331 -3.784 45.156 1.00 39.94 ? 519 LYS B CE 1 ATOM 3123 N NZ . LYS B 1 195 ? 144.487 -4.921 44.210 1.00 39.58 ? 519 LYS B NZ 1 ATOM 3124 N N . ASP B 1 196 ? 139.658 -1.065 43.689 1.00 35.99 ? 520 ASP B N 1 ATOM 3125 C CA . ASP B 1 196 ? 138.712 -1.375 42.631 1.00 35.55 ? 520 ASP B CA 1 ATOM 3126 C C . ASP B 1 196 ? 139.119 -2.603 41.829 1.00 34.63 ? 520 ASP B C 1 ATOM 3127 O O . ASP B 1 196 ? 139.429 -2.541 40.634 1.00 33.95 ? 520 ASP B O 1 ATOM 3128 C CB . ASP B 1 196 ? 138.552 -0.202 41.676 1.00 36.11 ? 520 ASP B CB 1 ATOM 3129 C CG . ASP B 1 196 ? 137.408 -0.415 40.688 1.00 37.33 ? 520 ASP B CG 1 ATOM 3130 O OD1 . ASP B 1 196 ? 136.531 -1.273 40.942 1.00 36.92 ? 520 ASP B OD1 1 ATOM 3131 O OD2 . ASP B 1 196 ? 137.388 0.275 39.646 1.00 39.03 ? 520 ASP B OD2 1 ATOM 3132 N N . GLU B 1 197 ? 139.111 -3.738 42.500 1.00 33.55 ? 521 GLU B N 1 ATOM 3133 C CA . GLU B 1 197 ? 139.393 -4.988 41.831 1.00 32.80 ? 521 GLU B CA 1 ATOM 3134 C C . GLU B 1 197 ? 138.772 -6.086 42.658 1.00 31.15 ? 521 GLU B C 1 ATOM 3135 O O . GLU B 1 197 ? 139.168 -6.292 43.806 1.00 31.87 ? 521 GLU B O 1 ATOM 3136 C CB . GLU B 1 197 ? 140.901 -5.214 41.720 1.00 33.29 ? 521 GLU B CB 1 ATOM 3137 C CG . GLU B 1 197 ? 141.279 -6.390 40.851 1.00 33.95 ? 521 GLU B CG 1 ATOM 3138 C CD . GLU B 1 197 ? 142.753 -6.658 40.875 1.00 35.66 ? 521 GLU B CD 1 ATOM 3139 O OE1 . GLU B 1 197 ? 143.391 -6.331 41.899 1.00 36.91 ? 521 GLU B OE1 1 ATOM 3140 O OE2 . GLU B 1 197 ? 143.275 -7.186 39.868 1.00 37.69 ? 521 GLU B OE2 1 ATOM 3141 N N . PHE B 1 198 ? 137.804 -6.777 42.063 1.00 29.17 ? 522 PHE B N 1 ATOM 3142 C CA . PHE B 1 198 ? 137.197 -7.943 42.695 1.00 27.08 ? 522 PHE B CA 1 ATOM 3143 C C . PHE B 1 198 ? 137.420 -9.200 41.845 1.00 25.31 ? 522 PHE B C 1 ATOM 3144 O O . PHE B 1 198 ? 137.319 -9.145 40.636 1.00 21.34 ? 522 PHE B O 1 ATOM 3145 C CB . PHE B 1 198 ? 135.708 -7.690 42.925 1.00 26.27 ? 522 PHE B CB 1 ATOM 3146 C CG . PHE B 1 198 ? 135.419 -6.455 43.725 1.00 24.24 ? 522 PHE B CG 1 ATOM 3147 C CD1 . PHE B 1 198 ? 135.582 -5.197 43.170 1.00 24.00 ? 522 PHE B CD1 1 ATOM 3148 C CD2 . PHE B 1 198 ? 134.966 -6.558 45.017 1.00 22.90 ? 522 PHE B CD2 1 ATOM 3149 C CE1 . PHE B 1 198 ? 135.300 -4.059 43.898 1.00 24.32 ? 522 PHE B CE1 1 ATOM 3150 C CE2 . PHE B 1 198 ? 134.683 -5.428 45.766 1.00 24.59 ? 522 PHE B CE2 1 ATOM 3151 C CZ . PHE B 1 198 ? 134.859 -4.166 45.209 1.00 24.64 ? 522 PHE B CZ 1 ATOM 3152 N N . ILE B 1 199 ? 137.727 -10.320 42.498 1.00 25.98 ? 523 ILE B N 1 ATOM 3153 C CA . ILE B 1 199 ? 138.100 -11.544 41.806 1.00 26.30 ? 523 ILE B CA 1 ATOM 3154 C C . ILE B 1 199 ? 137.072 -12.628 42.062 1.00 26.12 ? 523 ILE B C 1 ATOM 3155 O O . ILE B 1 199 ? 136.801 -12.998 43.188 1.00 26.13 ? 523 ILE B O 1 ATOM 3156 C CB . ILE B 1 199 ? 139.499 -12.037 42.225 1.00 27.25 ? 523 ILE B CB 1 ATOM 3157 C CG1 . ILE B 1 199 ? 140.525 -10.947 41.888 1.00 27.14 ? 523 ILE B CG1 1 ATOM 3158 C CG2 . ILE B 1 199 ? 139.866 -13.341 41.479 1.00 27.23 ? 523 ILE B CG2 1 ATOM 3159 C CD1 . ILE B 1 199 ? 141.919 -11.259 42.255 1.00 27.39 ? 523 ILE B CD1 1 ATOM 3160 N N . CYS B 1 200 ? 136.472 -13.108 40.987 1.00 26.69 ? 524 CYS B N 1 ATOM 3161 C CA . CYS B 1 200 ? 135.614 -14.266 41.054 1.00 26.91 ? 524 CYS B CA 1 ATOM 3162 C C . CYS B 1 200 ? 136.484 -15.483 40.759 1.00 26.19 ? 524 CYS B C 1 ATOM 3163 O O . CYS B 1 200 ? 137.154 -15.545 39.730 1.00 24.06 ? 524 CYS B O 1 ATOM 3164 C CB . CYS B 1 200 ? 134.495 -14.137 40.015 1.00 28.29 ? 524 CYS B CB 1 ATOM 3165 S SG . CYS B 1 200 ? 133.565 -15.651 39.791 1.00 28.58 ? 524 CYS B SG 1 ATOM 3166 N N . ARG B 1 201 ? 136.460 -16.441 41.675 1.00 26.40 ? 525 ARG B N 1 ATOM 3167 C CA . ARG B 1 201 ? 137.293 -17.622 41.595 1.00 27.06 ? 525 ARG B CA 1 ATOM 3168 C C . ARG B 1 201 ? 136.433 -18.842 41.715 1.00 25.57 ? 525 ARG B C 1 ATOM 3169 O O . ARG B 1 201 ? 135.737 -18.986 42.719 1.00 24.18 ? 525 ARG B O 1 ATOM 3170 C CB . ARG B 1 201 ? 138.272 -17.639 42.757 1.00 28.87 ? 525 ARG B CB 1 ATOM 3171 C CG . ARG B 1 201 ? 139.057 -18.913 42.876 1.00 30.29 ? 525 ARG B CG 1 ATOM 3172 C CD . ARG B 1 201 ? 140.517 -18.598 43.178 1.00 32.34 ? 525 ARG B CD 1 ATOM 3173 N NE . ARG B 1 201 ? 140.762 -18.357 44.586 1.00 33.71 ? 525 ARG B NE 1 ATOM 3174 C CZ . ARG B 1 201 ? 141.890 -17.840 45.076 1.00 35.58 ? 525 ARG B CZ 1 ATOM 3175 N NH1 . ARG B 1 201 ? 142.887 -17.471 44.277 1.00 36.52 ? 525 ARG B NH1 1 ATOM 3176 N NH2 . ARG B 1 201 ? 142.014 -17.664 46.386 1.00 36.01 ? 525 ARG B NH2 1 ATOM 3177 N N . ALA B 1 202 ? 136.511 -19.695 40.692 1.00 25.25 ? 526 ALA B N 1 ATOM 3178 C CA . ALA B 1 202 ? 135.830 -20.999 40.630 1.00 23.74 ? 526 ALA B CA 1 ATOM 3179 C C . ALA B 1 202 ? 136.755 -22.059 41.145 1.00 23.53 ? 526 ALA B C 1 ATOM 3180 O O . ALA B 1 202 ? 137.912 -22.046 40.739 1.00 25.36 ? 526 ALA B O 1 ATOM 3181 C CB . ALA B 1 202 ? 135.513 -21.351 39.203 1.00 21.69 ? 526 ALA B CB 1 ATOM 3182 N N . VAL B 1 203 ? 136.267 -22.958 41.996 1.00 21.60 ? 527 VAL B N 1 ATOM 3183 C CA . VAL B 1 203 ? 137.038 -24.101 42.419 1.00 23.23 ? 527 VAL B CA 1 ATOM 3184 C C . VAL B 1 203 ? 136.417 -25.363 41.861 1.00 25.30 ? 527 VAL B C 1 ATOM 3185 O O . VAL B 1 203 ? 135.285 -25.700 42.220 1.00 27.13 ? 527 VAL B O 1 ATOM 3186 C CB . VAL B 1 203 ? 137.085 -24.273 43.958 1.00 24.07 ? 527 VAL B CB 1 ATOM 3187 C CG1 . VAL B 1 203 ? 137.932 -25.499 44.325 1.00 23.97 ? 527 VAL B CG1 1 ATOM 3188 C CG2 . VAL B 1 203 ? 137.632 -23.035 44.672 1.00 22.56 ? 527 VAL B CG2 1 ATOM 3189 N N . HIS B 1 204 ? 137.173 -26.087 41.035 1.00 25.46 ? 528 HIS B N 1 ATOM 3190 C CA . HIS B 1 204 ? 136.658 -27.259 40.318 1.00 25.56 ? 528 HIS B CA 1 ATOM 3191 C C . HIS B 1 204 ? 137.826 -28.164 39.966 1.00 26.94 ? 528 HIS B C 1 ATOM 3192 O O . HIS B 1 204 ? 138.897 -27.696 39.602 1.00 29.52 ? 528 HIS B O 1 ATOM 3193 C CB . HIS B 1 204 ? 135.976 -26.788 39.033 1.00 26.26 ? 528 HIS B CB 1 ATOM 3194 C CG . HIS B 1 204 ? 135.297 -27.866 38.251 1.00 25.48 ? 528 HIS B CG 1 ATOM 3195 N ND1 . HIS B 1 204 ? 135.968 -28.705 37.389 1.00 25.65 ? 528 HIS B ND1 1 ATOM 3196 C CD2 . HIS B 1 204 ? 133.989 -28.213 38.177 1.00 26.27 ? 528 HIS B CD2 1 ATOM 3197 C CE1 . HIS B 1 204 ? 135.097 -29.526 36.824 1.00 26.85 ? 528 HIS B CE1 1 ATOM 3198 N NE2 . HIS B 1 204 ? 133.888 -29.248 37.284 1.00 24.67 ? 528 HIS B NE2 1 ATOM 3199 N N . GLU B 1 205 ? 137.603 -29.464 40.062 1.00 28.69 ? 529 GLU B N 1 ATOM 3200 C CA . GLU B 1 205 ? 138.653 -30.472 39.980 1.00 29.48 ? 529 GLU B CA 1 ATOM 3201 C C . GLU B 1 205 ? 139.377 -30.531 38.648 1.00 28.29 ? 529 GLU B C 1 ATOM 3202 O O . GLU B 1 205 ? 140.566 -30.847 38.611 1.00 27.83 ? 529 GLU B O 1 ATOM 3203 C CB . GLU B 1 205 ? 138.084 -31.854 40.307 1.00 31.11 ? 529 GLU B CB 1 ATOM 3204 C CG . GLU B 1 205 ? 136.898 -32.283 39.457 1.00 33.94 ? 529 GLU B CG 1 ATOM 3205 C CD . GLU B 1 205 ? 136.441 -33.706 39.799 1.00 37.80 ? 529 GLU B CD 1 ATOM 3206 O OE1 . GLU B 1 205 ? 135.252 -33.912 40.168 1.00 38.76 ? 529 GLU B OE1 1 ATOM 3207 O OE2 . GLU B 1 205 ? 137.295 -34.635 39.701 1.00 40.99 ? 529 GLU B OE2 1 ATOM 3208 N N . ALA B 1 206 ? 138.673 -30.227 37.564 1.00 27.70 ? 530 ALA B N 1 ATOM 3209 C CA . ALA B 1 206 ? 139.283 -30.207 36.237 1.00 26.96 ? 530 ALA B CA 1 ATOM 3210 C C . ALA B 1 206 ? 140.124 -28.964 35.936 1.00 27.15 ? 530 ALA B C 1 ATOM 3211 O O . ALA B 1 206 ? 140.832 -28.941 34.951 1.00 29.44 ? 530 ALA B O 1 ATOM 3212 C CB . ALA B 1 206 ? 138.208 -30.349 35.187 1.00 28.81 ? 530 ALA B CB 1 ATOM 3213 N N . ALA B 1 207 ? 140.039 -27.923 36.753 1.00 28.61 ? 531 ALA B N 1 ATOM 3214 C CA . ALA B 1 207 ? 140.879 -26.734 36.605 1.00 29.11 ? 531 ALA B CA 1 ATOM 3215 C C . ALA B 1 207 ? 142.302 -27.079 36.992 1.00 30.93 ? 531 ALA B C 1 ATOM 3216 O O . ALA B 1 207 ? 142.554 -27.584 38.083 1.00 35.26 ? 531 ALA B O 1 ATOM 3217 C CB . ALA B 1 207 ? 140.360 -25.618 37.487 1.00 28.12 ? 531 ALA B CB 1 ATOM 3218 N N . SER B 1 208 ? 143.237 -26.822 36.093 1.00 32.18 ? 532 SER B N 1 ATOM 3219 C CA . SER B 1 208 ? 144.589 -27.352 36.216 1.00 32.14 ? 532 SER B CA 1 ATOM 3220 C C . SER B 1 208 ? 145.574 -26.198 36.214 1.00 30.91 ? 532 SER B C 1 ATOM 3221 O O . SER B 1 208 ? 145.429 -25.285 35.410 1.00 32.32 ? 532 SER B O 1 ATOM 3222 C CB . SER B 1 208 ? 144.891 -28.275 35.033 1.00 33.23 ? 532 SER B CB 1 ATOM 3223 O OG . SER B 1 208 ? 146.244 -28.709 35.040 1.00 33.92 ? 532 SER B OG 1 ATOM 3224 N N . PRO B 1 209 ? 146.561 -26.224 37.121 1.00 30.12 ? 533 PRO B N 1 ATOM 3225 C CA . PRO B 1 209 ? 146.596 -27.158 38.242 1.00 31.35 ? 533 PRO B CA 1 ATOM 3226 C C . PRO B 1 209 ? 145.929 -26.397 39.380 1.00 31.36 ? 533 PRO B C 1 ATOM 3227 O O . PRO B 1 209 ? 145.284 -25.368 39.134 1.00 38.29 ? 533 PRO B O 1 ATOM 3228 C CB . PRO B 1 209 ? 148.102 -27.365 38.479 1.00 30.87 ? 533 PRO B CB 1 ATOM 3229 C CG . PRO B 1 209 ? 148.777 -26.110 37.880 1.00 29.84 ? 533 PRO B CG 1 ATOM 3230 C CD . PRO B 1 209 ? 147.698 -25.293 37.182 1.00 29.75 ? 533 PRO B CD 1 ATOM 3231 N N . SER B 1 210 ? 146.056 -26.856 40.608 1.00 29.02 ? 534 SER B N 1 ATOM 3232 C CA . SER B 1 210 ? 145.586 -26.038 41.717 1.00 27.53 ? 534 SER B CA 1 ATOM 3233 C C . SER B 1 210 ? 144.058 -25.860 41.752 1.00 26.20 ? 534 SER B C 1 ATOM 3234 O O . SER B 1 210 ? 143.548 -25.149 42.614 1.00 26.29 ? 534 SER B O 1 ATOM 3235 C CB . SER B 1 210 ? 146.259 -24.654 41.657 1.00 27.78 ? 534 SER B CB 1 ATOM 3236 O OG . SER B 1 210 ? 147.662 -24.744 41.460 1.00 27.11 ? 534 SER B OG 1 ATOM 3237 N N . GLN B 1 211 ? 143.338 -26.475 40.816 1.00 24.32 ? 535 GLN B N 1 ATOM 3238 C CA . GLN B 1 211 ? 141.876 -26.524 40.868 1.00 25.29 ? 535 GLN B CA 1 ATOM 3239 C C . GLN B 1 211 ? 141.148 -25.175 40.959 1.00 27.62 ? 535 GLN B C 1 ATOM 3240 O O . GLN B 1 211 ? 139.995 -25.068 41.430 1.00 30.06 ? 535 GLN B O 1 ATOM 3241 C CB . GLN B 1 211 ? 141.441 -27.435 42.017 1.00 25.39 ? 535 GLN B CB 1 ATOM 3242 C CG . GLN B 1 211 ? 141.721 -28.910 41.759 1.00 25.14 ? 535 GLN B CG 1 ATOM 3243 C CD . GLN B 1 211 ? 143.181 -29.269 41.957 1.00 23.75 ? 535 GLN B CD 1 ATOM 3244 O OE1 . GLN B 1 211 ? 143.779 -28.938 42.983 1.00 22.72 ? 535 GLN B OE1 1 ATOM 3245 N NE2 . GLN B 1 211 ? 143.752 -29.955 40.979 1.00 21.45 ? 535 GLN B NE2 1 ATOM 3246 N N . THR B 1 212 ? 141.797 -24.122 40.484 1.00 28.65 ? 536 THR B N 1 ATOM 3247 C CA . THR B 1 212 ? 141.168 -22.805 40.500 1.00 27.80 ? 536 THR B CA 1 ATOM 3248 C C . THR B 1 212 ? 141.263 -22.182 39.121 1.00 27.24 ? 536 THR B C 1 ATOM 3249 O O . THR B 1 212 ? 142.254 -22.332 38.437 1.00 27.43 ? 536 THR B O 1 ATOM 3250 C CB . THR B 1 212 ? 141.817 -21.876 41.544 1.00 27.52 ? 536 THR B CB 1 ATOM 3251 O OG1 . THR B 1 212 ? 143.242 -21.927 41.428 1.00 30.44 ? 536 THR B OG1 1 ATOM 3252 C CG2 . THR B 1 212 ? 141.455 -22.318 42.906 1.00 26.75 ? 536 THR B CG2 1 ATOM 3253 N N . VAL B 1 213 ? 140.198 -21.515 38.701 1.00 27.17 ? 537 VAL B N 1 ATOM 3254 C CA . VAL B 1 213 ? 140.262 -20.601 37.585 1.00 26.00 ? 537 VAL B CA 1 ATOM 3255 C C . VAL B 1 213 ? 139.621 -19.326 38.067 1.00 26.46 ? 537 VAL B C 1 ATOM 3256 O O . VAL B 1 213 ? 138.595 -19.356 38.732 1.00 27.90 ? 537 VAL B O 1 ATOM 3257 C CB . VAL B 1 213 ? 139.507 -21.123 36.357 1.00 25.75 ? 537 VAL B CB 1 ATOM 3258 C CG1 . VAL B 1 213 ? 139.680 -20.155 35.193 1.00 23.53 ? 537 VAL B CG1 1 ATOM 3259 C CG2 . VAL B 1 213 ? 139.989 -22.521 35.955 1.00 25.45 ? 537 VAL B CG2 1 ATOM 3260 N N . GLN B 1 214 ? 140.208 -18.188 37.748 1.00 27.83 ? 538 GLN B N 1 ATOM 3261 C CA . GLN B 1 214 ? 139.684 -16.950 38.300 1.00 27.93 ? 538 GLN B CA 1 ATOM 3262 C C . GLN B 1 214 ? 139.749 -15.795 37.319 1.00 28.35 ? 538 GLN B C 1 ATOM 3263 O O . GLN B 1 214 ? 140.493 -15.831 36.328 1.00 22.73 ? 538 GLN B O 1 ATOM 3264 C CB . GLN B 1 214 ? 140.469 -16.548 39.544 1.00 28.57 ? 538 GLN B CB 1 ATOM 3265 C CG . GLN B 1 214 ? 141.834 -15.956 39.265 1.00 28.73 ? 538 GLN B CG 1 ATOM 3266 C CD . GLN B 1 214 ? 142.474 -15.450 40.554 1.00 31.84 ? 538 GLN B CD 1 ATOM 3267 O OE1 . GLN B 1 214 ? 142.578 -16.189 41.553 1.00 33.03 ? 538 GLN B OE1 1 ATOM 3268 N NE2 . GLN B 1 214 ? 142.884 -14.182 40.552 1.00 32.48 ? 538 GLN B NE2 1 ATOM 3269 N N . ARG B 1 215 ? 138.979 -14.763 37.656 1.00 29.03 ? 539 ARG B N 1 ATOM 3270 C CA . ARG B 1 215 ? 138.800 -13.612 36.803 1.00 32.31 ? 539 ARG B CA 1 ATOM 3271 C C . ARG B 1 215 ? 138.583 -12.326 37.608 1.00 31.90 ? 539 ARG B C 1 ATOM 3272 O O . ARG B 1 215 ? 137.734 -12.267 38.505 1.00 31.91 ? 539 ARG B O 1 ATOM 3273 C CB . ARG B 1 215 ? 137.603 -13.848 35.892 1.00 35.29 ? 539 ARG B CB 1 ATOM 3274 C CG . ARG B 1 215 ? 137.653 -13.028 34.624 1.00 40.06 ? 539 ARG B CG 1 ATOM 3275 C CD . ARG B 1 215 ? 138.519 -13.681 33.554 1.00 42.32 ? 539 ARG B CD 1 ATOM 3276 N NE . ARG B 1 215 ? 138.573 -12.789 32.402 1.00 46.32 ? 539 ARG B NE 1 ATOM 3277 C CZ . ARG B 1 215 ? 139.101 -13.113 31.226 1.00 49.27 ? 539 ARG B CZ 1 ATOM 3278 N NH1 . ARG B 1 215 ? 139.610 -14.332 31.031 1.00 49.71 ? 539 ARG B NH1 1 ATOM 3279 N NH2 . ARG B 1 215 ? 139.112 -12.213 30.247 1.00 49.56 ? 539 ARG B NH2 1 ATOM 3280 N N . ALA B 1 216 ? 139.359 -11.300 37.271 1.00 30.22 ? 540 ALA B N 1 ATOM 3281 C CA . ALA B 1 216 ? 139.196 -9.969 37.848 1.00 29.24 ? 540 ALA B CA 1 ATOM 3282 C C . ALA B 1 216 ? 138.143 -9.166 37.096 1.00 28.81 ? 540 ALA B C 1 ATOM 3283 O O . ALA B 1 216 ? 138.044 -9.253 35.871 1.00 27.96 ? 540 ALA B O 1 ATOM 3284 C CB . ALA B 1 216 ? 140.513 -9.213 37.835 1.00 26.90 ? 540 ALA B CB 1 ATOM 3285 N N . VAL B 1 217 ? 137.363 -8.400 37.855 1.00 28.36 ? 541 VAL B N 1 ATOM 3286 C CA . VAL B 1 217 ? 136.534 -7.330 37.321 1.00 28.81 ? 541 VAL B CA 1 ATOM 3287 C C . VAL B 1 217 ? 136.640 -6.093 38.221 1.00 30.37 ? 541 VAL B C 1 ATOM 3288 O O . VAL B 1 217 ? 136.849 -6.185 39.436 1.00 30.38 ? 541 VAL B O 1 ATOM 3289 C CB . VAL B 1 217 ? 135.046 -7.724 37.250 1.00 28.45 ? 541 VAL B CB 1 ATOM 3290 C CG1 . VAL B 1 217 ? 134.465 -7.859 38.654 1.00 25.34 ? 541 VAL B CG1 1 ATOM 3291 C CG2 . VAL B 1 217 ? 134.241 -6.689 36.438 1.00 26.99 ? 541 VAL B CG2 1 ATOM 3292 N N . SER B 1 218 ? 136.493 -4.922 37.613 1.00 32.47 ? 542 SER B N 1 ATOM 3293 C CA . SER B 1 218 ? 136.464 -3.675 38.371 1.00 33.16 ? 542 SER B CA 1 ATOM 3294 C C . SER B 1 218 ? 135.189 -2.876 38.078 1.00 33.27 ? 542 SER B C 1 ATOM 3295 O O . SER B 1 218 ? 134.556 -3.044 37.040 1.00 31.40 ? 542 SER B O 1 ATOM 3296 C CB . SER B 1 218 ? 137.722 -2.860 38.081 1.00 32.66 ? 542 SER B CB 1 ATOM 3297 O OG . SER B 1 218 ? 137.822 -2.595 36.698 1.00 34.07 ? 542 SER B OG 1 ATOM 3298 N N . VAL B 1 219 ? 134.815 -2.007 39.014 1.00 35.87 ? 543 VAL B N 1 ATOM 3299 C CA . VAL B 1 219 ? 133.611 -1.200 38.888 1.00 36.66 ? 543 VAL B CA 1 ATOM 3300 C C . VAL B 1 219 ? 133.708 -0.089 37.821 1.00 38.96 ? 543 VAL B C 1 ATOM 3301 O O . VAL B 1 219 ? 132.707 0.262 37.191 1.00 36.57 ? 543 VAL B O 1 ATOM 3302 C CB . VAL B 1 219 ? 133.212 -0.636 40.262 1.00 36.50 ? 543 VAL B CB 1 ATOM 3303 C CG1 . VAL B 1 219 ? 131.940 0.208 40.161 1.00 35.93 ? 543 VAL B CG1 1 ATOM 3304 C CG2 . VAL B 1 219 ? 132.994 -1.778 41.233 1.00 34.81 ? 543 VAL B CG2 1 ATOM 3305 N N . ASN B 1 220 ? 134.907 0.443 37.590 1.00 42.64 ? 544 ASN B N 1 ATOM 3306 C CA . ASN B 1 220 ? 135.068 1.562 36.655 1.00 45.60 ? 544 ASN B CA 1 ATOM 3307 C C . ASN B 1 220 ? 136.163 1.398 35.585 1.00 47.06 ? 544 ASN B C 1 ATOM 3308 O O . ASN B 1 220 ? 136.326 2.263 34.717 1.00 47.43 ? 544 ASN B O 1 ATOM 3309 C CB . ASN B 1 220 ? 135.307 2.850 37.454 1.00 46.61 ? 544 ASN B CB 1 ATOM 3310 C CG . ASN B 1 220 ? 134.056 3.327 38.183 1.00 47.07 ? 544 ASN B CG 1 ATOM 3311 O OD1 . ASN B 1 220 ? 134.103 3.786 39.332 1.00 46.16 ? 544 ASN B OD1 1 ATOM 3312 N ND2 . ASN B 1 220 ? 132.925 3.219 37.502 1.00 47.93 ? 544 ASN B ND2 1 ATOM 3313 N N . VAL C 1 12 ? 75.463 -43.935 9.830 1.00 49.76 ? 336 VAL C N 1 ATOM 3314 C CA . VAL C 1 12 ? 74.861 -42.961 8.871 1.00 50.35 ? 336 VAL C CA 1 ATOM 3315 C C . VAL C 1 12 ? 74.895 -41.525 9.372 1.00 50.06 ? 336 VAL C C 1 ATOM 3316 O O . VAL C 1 12 ? 74.601 -41.260 10.539 1.00 50.56 ? 336 VAL C O 1 ATOM 3317 C CB . VAL C 1 12 ? 73.387 -43.284 8.589 1.00 50.64 ? 336 VAL C CB 1 ATOM 3318 C CG1 . VAL C 1 12 ? 72.825 -42.296 7.570 1.00 50.19 ? 336 VAL C CG1 1 ATOM 3319 C CG2 . VAL C 1 12 ? 73.248 -44.734 8.130 1.00 50.89 ? 336 VAL C CG2 1 ATOM 3320 N N . SER C 1 13 ? 75.236 -40.603 8.474 1.00 49.34 ? 337 SER C N 1 ATOM 3321 C CA . SER C 1 13 ? 75.261 -39.176 8.801 1.00 48.74 ? 337 SER C CA 1 ATOM 3322 C C . SER C 1 13 ? 74.532 -38.301 7.763 1.00 47.74 ? 337 SER C C 1 ATOM 3323 O O . SER C 1 13 ? 74.278 -38.719 6.626 1.00 47.00 ? 337 SER C O 1 ATOM 3324 C CB . SER C 1 13 ? 76.709 -38.705 9.016 1.00 49.07 ? 337 SER C CB 1 ATOM 3325 O OG . SER C 1 13 ? 77.552 -39.031 7.926 1.00 48.98 ? 337 SER C OG 1 ATOM 3326 N N . ALA C 1 14 ? 74.175 -37.084 8.164 1.00 46.80 ? 338 ALA C N 1 ATOM 3327 C CA . ALA C 1 14 ? 73.506 -36.158 7.253 1.00 45.84 ? 338 ALA C CA 1 ATOM 3328 C C . ALA C 1 14 ? 74.105 -34.767 7.305 1.00 44.93 ? 338 ALA C C 1 ATOM 3329 O O . ALA C 1 14 ? 74.669 -34.343 8.305 1.00 44.29 ? 338 ALA C O 1 ATOM 3330 C CB . ALA C 1 14 ? 72.016 -36.094 7.539 1.00 46.21 ? 338 ALA C CB 1 ATOM 3331 N N . TYR C 1 15 ? 73.956 -34.068 6.188 1.00 45.40 ? 339 TYR C N 1 ATOM 3332 C CA . TYR C 1 15 ? 74.502 -32.735 5.994 1.00 45.47 ? 339 TYR C CA 1 ATOM 3333 C C . TYR C 1 15 ? 73.493 -31.880 5.227 1.00 44.19 ? 339 TYR C C 1 ATOM 3334 O O . TYR C 1 15 ? 72.650 -32.403 4.492 1.00 44.66 ? 339 TYR C O 1 ATOM 3335 C CB . TYR C 1 15 ? 75.787 -32.823 5.174 1.00 46.74 ? 339 TYR C CB 1 ATOM 3336 C CG . TYR C 1 15 ? 76.817 -33.786 5.725 1.00 47.85 ? 339 TYR C CG 1 ATOM 3337 C CD1 . TYR C 1 15 ? 76.964 -35.066 5.184 1.00 47.36 ? 339 TYR C CD1 1 ATOM 3338 C CD2 . TYR C 1 15 ? 77.647 -33.408 6.786 1.00 47.66 ? 339 TYR C CD2 1 ATOM 3339 C CE1 . TYR C 1 15 ? 77.917 -35.947 5.689 1.00 48.04 ? 339 TYR C CE1 1 ATOM 3340 C CE2 . TYR C 1 15 ? 78.595 -34.273 7.298 1.00 48.03 ? 339 TYR C CE2 1 ATOM 3341 C CZ . TYR C 1 15 ? 78.731 -35.544 6.749 1.00 48.64 ? 339 TYR C CZ 1 ATOM 3342 O OH . TYR C 1 15 ? 79.683 -36.400 7.264 1.00 48.03 ? 339 TYR C OH 1 ATOM 3343 N N . LEU C 1 16 ? 73.584 -30.565 5.396 1.00 42.05 ? 340 LEU C N 1 ATOM 3344 C CA . LEU C 1 16 ? 72.638 -29.650 4.782 1.00 40.82 ? 340 LEU C CA 1 ATOM 3345 C C . LEU C 1 16 ? 73.401 -28.412 4.383 1.00 40.24 ? 340 LEU C C 1 ATOM 3346 O O . LEU C 1 16 ? 73.892 -27.683 5.239 1.00 40.86 ? 340 LEU C O 1 ATOM 3347 C CB . LEU C 1 16 ? 71.516 -29.265 5.748 1.00 40.06 ? 340 LEU C CB 1 ATOM 3348 C CG . LEU C 1 16 ? 70.386 -28.415 5.167 1.00 39.70 ? 340 LEU C CG 1 ATOM 3349 C CD1 . LEU C 1 16 ? 69.765 -29.112 3.940 1.00 38.58 ? 340 LEU C CD1 1 ATOM 3350 C CD2 . LEU C 1 16 ? 69.329 -28.111 6.236 1.00 38.02 ? 340 LEU C CD2 1 ATOM 3351 N N . SER C 1 17 ? 73.507 -28.191 3.079 1.00 38.66 ? 341 SER C N 1 ATOM 3352 C CA . SER C 1 17 ? 74.362 -27.145 2.572 1.00 37.50 ? 341 SER C CA 1 ATOM 3353 C C . SER C 1 17 ? 73.538 -25.910 2.268 1.00 36.65 ? 341 SER C C 1 ATOM 3354 O O . SER C 1 17 ? 72.314 -25.954 2.175 1.00 35.82 ? 341 SER C O 1 ATOM 3355 C CB . SER C 1 17 ? 75.054 -27.602 1.293 1.00 38.23 ? 341 SER C CB 1 ATOM 3356 O OG . SER C 1 17 ? 74.080 -27.763 0.282 1.00 39.55 ? 341 SER C OG 1 ATOM 3357 N N . ARG C 1 18 ? 74.248 -24.803 2.101 1.00 35.04 ? 342 ARG C N 1 ATOM 3358 C CA . ARG C 1 18 ? 73.647 -23.550 1.728 1.00 32.36 ? 342 ARG C CA 1 ATOM 3359 C C . ARG C 1 18 ? 73.767 -23.417 0.210 1.00 32.36 ? 342 ARG C C 1 ATOM 3360 O O . ARG C 1 18 ? 74.498 -24.180 -0.417 1.00 35.63 ? 342 ARG C O 1 ATOM 3361 C CB . ARG C 1 18 ? 74.327 -22.405 2.490 1.00 31.47 ? 342 ARG C CB 1 ATOM 3362 C CG . ARG C 1 18 ? 74.156 -22.486 4.013 1.00 30.45 ? 342 ARG C CG 1 ATOM 3363 C CD . ARG C 1 18 ? 74.814 -21.352 4.778 1.00 29.75 ? 342 ARG C CD 1 ATOM 3364 N NE . ARG C 1 18 ? 76.265 -21.431 4.733 1.00 30.67 ? 342 ARG C NE 1 ATOM 3365 C CZ . ARG C 1 18 ? 77.018 -22.074 5.626 1.00 30.99 ? 342 ARG C CZ 1 ATOM 3366 N NH1 . ARG C 1 18 ? 76.460 -22.707 6.636 1.00 30.46 ? 342 ARG C NH1 1 ATOM 3367 N NH2 . ARG C 1 18 ? 78.339 -22.101 5.502 1.00 30.82 ? 342 ARG C NH2 1 ATOM 3368 N N . PRO C 1 19 ? 73.029 -22.474 -0.397 1.00 31.86 ? 343 PRO C N 1 ATOM 3369 C CA . PRO C 1 19 ? 73.170 -22.214 -1.818 1.00 32.04 ? 343 PRO C CA 1 ATOM 3370 C C . PRO C 1 19 ? 74.537 -21.664 -2.091 1.00 30.78 ? 343 PRO C C 1 ATOM 3371 O O . PRO C 1 19 ? 75.119 -21.031 -1.218 1.00 30.94 ? 343 PRO C O 1 ATOM 3372 C CB . PRO C 1 19 ? 72.160 -21.100 -2.076 1.00 31.84 ? 343 PRO C CB 1 ATOM 3373 C CG . PRO C 1 19 ? 71.197 -21.229 -1.003 1.00 31.98 ? 343 PRO C CG 1 ATOM 3374 C CD . PRO C 1 19 ? 71.989 -21.620 0.188 1.00 32.23 ? 343 PRO C CD 1 ATOM 3375 N N . SER C 1 20 ? 75.021 -21.896 -3.301 1.00 28.88 ? 344 SER C N 1 ATOM 3376 C CA . SER C 1 20 ? 76.211 -21.227 -3.756 1.00 26.92 ? 344 SER C CA 1 ATOM 3377 C C . SER C 1 20 ? 75.853 -19.813 -4.156 1.00 25.81 ? 344 SER C C 1 ATOM 3378 O O . SER C 1 20 ? 74.795 -19.577 -4.753 1.00 23.00 ? 344 SER C O 1 ATOM 3379 C CB . SER C 1 20 ? 76.816 -21.981 -4.932 1.00 27.80 ? 344 SER C CB 1 ATOM 3380 O OG . SER C 1 20 ? 76.126 -21.692 -6.135 1.00 30.37 ? 344 SER C OG 1 ATOM 3381 N N . PRO C 1 21 ? 76.743 -18.864 -3.829 1.00 26.49 ? 345 PRO C N 1 ATOM 3382 C CA . PRO C 1 21 ? 76.555 -17.491 -4.257 1.00 26.34 ? 345 PRO C CA 1 ATOM 3383 C C . PRO C 1 21 ? 76.324 -17.382 -5.757 1.00 27.58 ? 345 PRO C C 1 ATOM 3384 O O . PRO C 1 21 ? 75.494 -16.590 -6.189 1.00 28.53 ? 345 PRO C O 1 ATOM 3385 C CB . PRO C 1 21 ? 77.852 -16.807 -3.825 1.00 25.47 ? 345 PRO C CB 1 ATOM 3386 C CG . PRO C 1 21 ? 78.303 -17.587 -2.653 1.00 26.09 ? 345 PRO C CG 1 ATOM 3387 C CD . PRO C 1 21 ? 77.899 -19.003 -2.923 1.00 26.27 ? 345 PRO C CD 1 ATOM 3388 N N . PHE C 1 22 ? 77.021 -18.179 -6.557 1.00 28.77 ? 346 PHE C N 1 ATOM 3389 C CA . PHE C 1 22 ? 76.753 -18.157 -7.987 1.00 29.66 ? 346 PHE C CA 1 ATOM 3390 C C . PHE C 1 22 ? 75.279 -18.396 -8.282 1.00 29.32 ? 346 PHE C C 1 ATOM 3391 O O . PHE C 1 22 ? 74.611 -17.590 -8.909 1.00 29.98 ? 346 PHE C O 1 ATOM 3392 C CB . PHE C 1 22 ? 77.564 -19.240 -8.675 1.00 30.92 ? 346 PHE C CB 1 ATOM 3393 C CG . PHE C 1 22 ? 77.359 -19.309 -10.159 1.00 30.29 ? 346 PHE C CG 1 ATOM 3394 C CD1 . PHE C 1 22 ? 77.481 -18.175 -10.951 1.00 31.57 ? 346 PHE C CD1 1 ATOM 3395 C CD2 . PHE C 1 22 ? 77.067 -20.513 -10.757 1.00 29.86 ? 346 PHE C CD2 1 ATOM 3396 C CE1 . PHE C 1 22 ? 77.310 -18.236 -12.331 1.00 31.52 ? 346 PHE C CE1 1 ATOM 3397 C CE2 . PHE C 1 22 ? 76.895 -20.596 -12.124 1.00 31.18 ? 346 PHE C CE2 1 ATOM 3398 C CZ . PHE C 1 22 ? 77.017 -19.451 -12.921 1.00 31.35 ? 346 PHE C CZ 1 ATOM 3399 N N . ASP C 1 23 ? 74.781 -19.532 -7.843 1.00 29.14 ? 347 ASP C N 1 ATOM 3400 C CA . ASP C 1 23 ? 73.376 -19.841 -8.030 1.00 32.33 ? 347 ASP C CA 1 ATOM 3401 C C . ASP C 1 23 ? 72.474 -18.737 -7.469 1.00 32.72 ? 347 ASP C C 1 ATOM 3402 O O . ASP C 1 23 ? 71.438 -18.402 -8.031 1.00 32.67 ? 347 ASP C O 1 ATOM 3403 C CB . ASP C 1 23 ? 73.066 -21.181 -7.358 1.00 32.04 ? 347 ASP C CB 1 ATOM 3404 C CG . ASP C 1 23 ? 73.669 -22.345 -8.106 1.00 32.47 ? 347 ASP C CG 1 ATOM 3405 O OD1 . ASP C 1 23 ? 73.533 -23.493 -7.649 1.00 32.01 ? 347 ASP C OD1 1 ATOM 3406 O OD2 . ASP C 1 23 ? 74.297 -22.112 -9.158 1.00 35.25 ? 347 ASP C OD2 1 ATOM 3407 N N . LEU C 1 24 ? 72.877 -18.171 -6.345 1.00 33.55 ? 348 LEU C N 1 ATOM 3408 C CA . LEU C 1 24 ? 72.000 -17.276 -5.617 1.00 33.20 ? 348 LEU C CA 1 ATOM 3409 C C . LEU C 1 24 ? 71.975 -15.896 -6.287 1.00 32.42 ? 348 LEU C C 1 ATOM 3410 O O . LEU C 1 24 ? 70.927 -15.255 -6.370 1.00 32.48 ? 348 LEU C O 1 ATOM 3411 C CB . LEU C 1 24 ? 72.458 -17.188 -4.161 1.00 32.63 ? 348 LEU C CB 1 ATOM 3412 C CG . LEU C 1 24 ? 71.609 -16.285 -3.273 1.00 34.02 ? 348 LEU C CG 1 ATOM 3413 C CD1 . LEU C 1 24 ? 70.162 -16.756 -3.276 1.00 32.65 ? 348 LEU C CD1 1 ATOM 3414 C CD2 . LEU C 1 24 ? 72.197 -16.204 -1.844 1.00 33.34 ? 348 LEU C CD2 1 ATOM 3415 N N . PHE C 1 25 ? 73.125 -15.445 -6.772 1.00 30.83 ? 349 PHE C N 1 ATOM 3416 C CA . PHE C 1 25 ? 73.284 -14.039 -7.123 1.00 30.29 ? 349 PHE C CA 1 ATOM 3417 C C . PHE C 1 25 ? 73.388 -13.806 -8.614 1.00 31.15 ? 349 PHE C C 1 ATOM 3418 O O . PHE C 1 25 ? 72.974 -12.755 -9.085 1.00 31.20 ? 349 PHE C O 1 ATOM 3419 C CB . PHE C 1 25 ? 74.516 -13.431 -6.436 1.00 28.92 ? 349 PHE C CB 1 ATOM 3420 C CG . PHE C 1 25 ? 74.384 -13.317 -4.943 1.00 27.55 ? 349 PHE C CG 1 ATOM 3421 C CD1 . PHE C 1 25 ? 75.343 -13.862 -4.114 1.00 26.16 ? 349 PHE C CD1 1 ATOM 3422 C CD2 . PHE C 1 25 ? 73.289 -12.683 -4.365 1.00 27.12 ? 349 PHE C CD2 1 ATOM 3423 C CE1 . PHE C 1 25 ? 75.220 -13.779 -2.736 1.00 26.47 ? 349 PHE C CE1 1 ATOM 3424 C CE2 . PHE C 1 25 ? 73.171 -12.587 -2.984 1.00 26.36 ? 349 PHE C CE2 1 ATOM 3425 C CZ . PHE C 1 25 ? 74.136 -13.144 -2.169 1.00 25.96 ? 349 PHE C CZ 1 ATOM 3426 N N . ILE C 1 26 ? 73.940 -14.772 -9.342 1.00 32.15 ? 350 ILE C N 1 ATOM 3427 C CA . ILE C 1 26 ? 74.065 -14.672 -10.790 1.00 33.52 ? 350 ILE C CA 1 ATOM 3428 C C . ILE C 1 26 ? 72.926 -15.406 -11.512 1.00 35.56 ? 350 ILE C C 1 ATOM 3429 O O . ILE C 1 26 ? 72.121 -14.777 -12.204 1.00 34.48 ? 350 ILE C O 1 ATOM 3430 C CB . ILE C 1 26 ? 75.434 -15.199 -11.243 1.00 33.46 ? 350 ILE C CB 1 ATOM 3431 C CG1 . ILE C 1 26 ? 76.535 -14.552 -10.403 1.00 33.00 ? 350 ILE C CG1 1 ATOM 3432 C CG2 . ILE C 1 26 ? 75.669 -14.901 -12.712 1.00 33.44 ? 350 ILE C CG2 1 ATOM 3433 C CD1 . ILE C 1 26 ? 76.465 -13.033 -10.387 1.00 32.28 ? 350 ILE C CD1 1 ATOM 3434 N N . ARG C 1 27 ? 72.836 -16.723 -11.338 1.00 37.57 ? 351 ARG C N 1 ATOM 3435 C CA . ARG C 1 27 ? 71.768 -17.505 -11.970 1.00 39.96 ? 351 ARG C CA 1 ATOM 3436 C C . ARG C 1 27 ? 70.392 -17.226 -11.376 1.00 40.30 ? 351 ARG C C 1 ATOM 3437 O O . ARG C 1 27 ? 69.386 -17.597 -11.950 1.00 40.11 ? 351 ARG C O 1 ATOM 3438 C CB . ARG C 1 27 ? 72.037 -18.999 -11.826 1.00 40.99 ? 351 ARG C CB 1 ATOM 3439 C CG . ARG C 1 27 ? 73.286 -19.444 -12.509 1.00 42.95 ? 351 ARG C CG 1 ATOM 3440 C CD . ARG C 1 27 ? 73.445 -20.950 -12.428 1.00 44.72 ? 351 ARG C CD 1 ATOM 3441 N NE . ARG C 1 27 ? 72.397 -21.659 -13.150 1.00 45.61 ? 351 ARG C NE 1 ATOM 3442 C CZ . ARG C 1 27 ? 71.500 -22.437 -12.560 1.00 48.47 ? 351 ARG C CZ 1 ATOM 3443 N NH1 . ARG C 1 27 ? 71.542 -22.587 -11.241 1.00 50.57 ? 351 ARG C NH1 1 ATOM 3444 N NH2 . ARG C 1 27 ? 70.564 -23.060 -13.272 1.00 48.68 ? 351 ARG C NH2 1 ATOM 3445 N N . LYS C 1 28 ? 70.351 -16.601 -10.207 1.00 42.08 ? 352 LYS C N 1 ATOM 3446 C CA . LYS C 1 28 ? 69.093 -16.275 -9.560 1.00 42.22 ? 352 LYS C CA 1 ATOM 3447 C C . LYS C 1 28 ? 68.207 -17.485 -9.318 1.00 40.72 ? 352 LYS C C 1 ATOM 3448 O O . LYS C 1 28 ? 67.002 -17.343 -9.161 1.00 41.02 ? 352 LYS C O 1 ATOM 3449 C CB . LYS C 1 28 ? 68.337 -15.261 -10.407 1.00 43.99 ? 352 LYS C CB 1 ATOM 3450 C CG . LYS C 1 28 ? 68.965 -13.891 -10.379 1.00 46.11 ? 352 LYS C CG 1 ATOM 3451 C CD . LYS C 1 28 ? 68.443 -13.079 -9.204 1.00 47.68 ? 352 LYS C CD 1 ATOM 3452 C CE . LYS C 1 28 ? 69.116 -11.716 -9.187 1.00 48.68 ? 352 LYS C CE 1 ATOM 3453 N NZ . LYS C 1 28 ? 70.597 -11.899 -9.262 1.00 49.25 ? 352 LYS C NZ 1 ATOM 3454 N N . SER C 1 29 ? 68.787 -18.676 -9.269 1.00 38.95 ? 353 SER C N 1 ATOM 3455 C CA . SER C 1 29 ? 68.015 -19.845 -8.856 1.00 37.01 ? 353 SER C CA 1 ATOM 3456 C C . SER C 1 29 ? 68.782 -20.642 -7.841 1.00 34.02 ? 353 SER C C 1 ATOM 3457 O O . SER C 1 29 ? 69.435 -21.604 -8.193 1.00 34.96 ? 353 SER C O 1 ATOM 3458 C CB . SER C 1 29 ? 67.732 -20.733 -10.054 1.00 37.43 ? 353 SER C CB 1 ATOM 3459 O OG . SER C 1 29 ? 68.783 -20.549 -10.967 1.00 40.69 ? 353 SER C OG 1 ATOM 3460 N N . PRO C 1 30 ? 68.701 -20.252 -6.573 1.00 31.50 ? 354 PRO C N 1 ATOM 3461 C CA . PRO C 1 30 ? 69.419 -20.943 -5.515 1.00 31.84 ? 354 PRO C CA 1 ATOM 3462 C C . PRO C 1 30 ? 68.759 -22.250 -5.104 1.00 31.13 ? 354 PRO C C 1 ATOM 3463 O O . PRO C 1 30 ? 67.545 -22.371 -5.183 1.00 30.68 ? 354 PRO C O 1 ATOM 3464 C CB . PRO C 1 30 ? 69.367 -19.950 -4.365 1.00 32.43 ? 354 PRO C CB 1 ATOM 3465 C CG . PRO C 1 30 ? 68.078 -19.230 -4.590 1.00 33.10 ? 354 PRO C CG 1 ATOM 3466 C CD . PRO C 1 30 ? 67.922 -19.116 -6.067 1.00 32.17 ? 354 PRO C CD 1 ATOM 3467 N N . THR C 1 31 ? 69.559 -23.224 -4.676 1.00 29.61 ? 355 THR C N 1 ATOM 3468 C CA . THR C 1 31 ? 69.040 -24.508 -4.204 1.00 28.04 ? 355 THR C CA 1 ATOM 3469 C C . THR C 1 31 ? 69.830 -24.872 -2.938 1.00 29.01 ? 355 THR C C 1 ATOM 3470 O O . THR C 1 31 ? 70.961 -24.432 -2.786 1.00 30.24 ? 355 THR C O 1 ATOM 3471 C CB . THR C 1 31 ? 69.250 -25.666 -5.213 1.00 25.87 ? 355 THR C CB 1 ATOM 3472 O OG1 . THR C 1 31 ? 70.653 -25.846 -5.393 1.00 26.97 ? 355 THR C OG1 1 ATOM 3473 C CG2 . THR C 1 31 ? 68.586 -25.439 -6.581 1.00 22.06 ? 355 THR C CG2 1 ATOM 3474 N N . ILE C 1 32 ? 69.235 -25.654 -2.036 1.00 28.00 ? 356 ILE C N 1 ATOM 3475 C CA . ILE C 1 32 ? 69.971 -26.271 -0.931 1.00 27.71 ? 356 ILE C CA 1 ATOM 3476 C C . ILE C 1 32 ? 69.872 -27.774 -1.067 1.00 28.42 ? 356 ILE C C 1 ATOM 3477 O O . ILE C 1 32 ? 68.936 -28.286 -1.687 1.00 27.78 ? 356 ILE C O 1 ATOM 3478 C CB . ILE C 1 32 ? 69.468 -25.841 0.459 1.00 27.38 ? 356 ILE C CB 1 ATOM 3479 C CG1 . ILE C 1 32 ? 67.994 -26.195 0.653 1.00 27.76 ? 356 ILE C CG1 1 ATOM 3480 C CG2 . ILE C 1 32 ? 69.667 -24.329 0.635 1.00 27.31 ? 356 ILE C CG2 1 ATOM 3481 C CD1 . ILE C 1 32 ? 67.433 -25.702 2.005 1.00 28.72 ? 356 ILE C CD1 1 ATOM 3482 N N . THR C 1 33 ? 70.855 -28.475 -0.515 1.00 29.56 ? 357 THR C N 1 ATOM 3483 C CA . THR C 1 33 ? 70.926 -29.919 -0.680 1.00 32.84 ? 357 THR C CA 1 ATOM 3484 C C . THR C 1 33 ? 71.044 -30.637 0.656 1.00 35.33 ? 357 THR C C 1 ATOM 3485 O O . THR C 1 33 ? 71.896 -30.298 1.479 1.00 37.74 ? 357 THR C O 1 ATOM 3486 C CB . THR C 1 33 ? 72.143 -30.309 -1.542 1.00 31.66 ? 357 THR C CB 1 ATOM 3487 O OG1 . THR C 1 33 ? 72.078 -29.580 -2.775 1.00 30.62 ? 357 THR C OG1 1 ATOM 3488 C CG2 . THR C 1 33 ? 72.153 -31.809 -1.791 1.00 28.77 ? 357 THR C CG2 1 ATOM 3489 N N . CYS C 1 34 ? 70.190 -31.632 0.859 1.00 36.95 ? 358 CYS C N 1 ATOM 3490 C CA . CYS C 1 34 ? 70.265 -32.489 2.029 1.00 37.37 ? 358 CYS C CA 1 ATOM 3491 C C . CYS C 1 34 ? 70.994 -33.777 1.624 1.00 38.16 ? 358 CYS C C 1 ATOM 3492 O O . CYS C 1 34 ? 70.473 -34.581 0.858 1.00 34.01 ? 358 CYS C O 1 ATOM 3493 C CB . CYS C 1 34 ? 68.847 -32.818 2.493 1.00 38.57 ? 358 CYS C CB 1 ATOM 3494 S SG . CYS C 1 34 ? 68.776 -33.588 4.110 1.00 40.41 ? 358 CYS C SG 1 ATOM 3495 N N . LEU C 1 35 ? 72.197 -33.976 2.148 1.00 39.79 ? 359 LEU C N 1 ATOM 3496 C CA . LEU C 1 35 ? 73.003 -35.132 1.782 1.00 41.45 ? 359 LEU C CA 1 ATOM 3497 C C . LEU C 1 35 ? 73.000 -36.183 2.886 1.00 43.08 ? 359 LEU C C 1 ATOM 3498 O O . LEU C 1 35 ? 73.444 -35.913 3.994 1.00 45.04 ? 359 LEU C O 1 ATOM 3499 C CB . LEU C 1 35 ? 74.432 -34.669 1.524 1.00 41.39 ? 359 LEU C CB 1 ATOM 3500 C CG . LEU C 1 35 ? 75.494 -35.733 1.296 1.00 40.87 ? 359 LEU C CG 1 ATOM 3501 C CD1 . LEU C 1 35 ? 75.213 -36.460 -0.011 1.00 39.86 ? 359 LEU C CD1 1 ATOM 3502 C CD2 . LEU C 1 35 ? 76.867 -35.071 1.321 1.00 40.35 ? 359 LEU C CD2 1 ATOM 3503 N N . VAL C 1 36 ? 72.502 -37.378 2.584 1.00 44.95 ? 360 VAL C N 1 ATOM 3504 C CA . VAL C 1 36 ? 72.557 -38.488 3.528 1.00 46.50 ? 360 VAL C CA 1 ATOM 3505 C C . VAL C 1 36 ? 73.577 -39.528 3.066 1.00 48.30 ? 360 VAL C C 1 ATOM 3506 O O . VAL C 1 36 ? 73.400 -40.157 2.031 1.00 47.93 ? 360 VAL C O 1 ATOM 3507 C CB . VAL C 1 36 ? 71.187 -39.162 3.695 1.00 46.59 ? 360 VAL C CB 1 ATOM 3508 C CG1 . VAL C 1 36 ? 71.303 -40.346 4.642 1.00 46.66 ? 360 VAL C CG1 1 ATOM 3509 C CG2 . VAL C 1 36 ? 70.151 -38.166 4.193 1.00 45.48 ? 360 VAL C CG2 1 ATOM 3510 N N . VAL C 1 37 ? 74.650 -39.685 3.839 1.00 51.25 ? 361 VAL C N 1 ATOM 3511 C CA . VAL C 1 37 ? 75.668 -40.707 3.613 1.00 52.40 ? 361 VAL C CA 1 ATOM 3512 C C . VAL C 1 37 ? 75.373 -41.940 4.475 1.00 55.47 ? 361 VAL C C 1 ATOM 3513 O O . VAL C 1 37 ? 75.510 -41.897 5.703 1.00 55.35 ? 361 VAL C O 1 ATOM 3514 C CB . VAL C 1 37 ? 77.069 -40.166 3.963 1.00 51.92 ? 361 VAL C CB 1 ATOM 3515 C CG1 . VAL C 1 37 ? 78.143 -41.232 3.728 1.00 51.27 ? 361 VAL C CG1 1 ATOM 3516 C CG2 . VAL C 1 37 ? 77.364 -38.914 3.157 1.00 51.32 ? 361 VAL C CG2 1 ATOM 3517 N N . ASP C 1 38 ? 74.960 -43.032 3.830 1.00 58.60 ? 362 ASP C N 1 ATOM 3518 C CA . ASP C 1 38 ? 74.718 -44.297 4.524 1.00 60.82 ? 362 ASP C CA 1 ATOM 3519 C C . ASP C 1 38 ? 75.798 -45.317 4.180 1.00 62.31 ? 362 ASP C C 1 ATOM 3520 O O . ASP C 1 38 ? 75.811 -45.863 3.075 1.00 62.61 ? 362 ASP C O 1 ATOM 3521 C CB . ASP C 1 38 ? 73.339 -44.862 4.170 1.00 61.30 ? 362 ASP C CB 1 ATOM 3522 C CG . ASP C 1 38 ? 73.101 -46.245 4.769 1.00 61.70 ? 362 ASP C CG 1 ATOM 3523 O OD1 . ASP C 1 38 ? 73.329 -46.429 5.990 1.00 61.74 ? 362 ASP C OD1 1 ATOM 3524 O OD2 . ASP C 1 38 ? 72.681 -47.154 4.013 1.00 61.47 ? 362 ASP C OD2 1 ATOM 3525 N N . LEU C 1 39 ? 76.684 -45.569 5.142 1.00 64.44 ? 363 LEU C N 1 ATOM 3526 C CA . LEU C 1 39 ? 77.832 -46.469 4.963 1.00 66.78 ? 363 LEU C CA 1 ATOM 3527 C C . LEU C 1 39 ? 77.473 -47.950 4.721 1.00 67.79 ? 363 LEU C C 1 ATOM 3528 O O . LEU C 1 39 ? 78.228 -48.664 4.053 1.00 67.70 ? 363 LEU C O 1 ATOM 3529 C CB . LEU C 1 39 ? 78.784 -46.361 6.166 1.00 67.40 ? 363 LEU C CB 1 ATOM 3530 C CG . LEU C 1 39 ? 79.758 -45.172 6.266 1.00 68.01 ? 363 LEU C CG 1 ATOM 3531 C CD1 . LEU C 1 39 ? 79.060 -43.830 6.547 1.00 67.50 ? 363 LEU C CD1 1 ATOM 3532 C CD2 . LEU C 1 39 ? 80.820 -45.461 7.337 1.00 68.03 ? 363 LEU C CD2 1 ATOM 3533 N N . ALA C 1 40 ? 76.340 -48.406 5.262 1.00 68.91 ? 364 ALA C N 1 ATOM 3534 C CA . ALA C 1 40 ? 75.846 -49.775 5.040 1.00 69.76 ? 364 ALA C CA 1 ATOM 3535 C C . ALA C 1 40 ? 74.382 -49.806 4.551 1.00 70.21 ? 364 ALA C C 1 ATOM 3536 O O . ALA C 1 40 ? 73.455 -49.734 5.363 1.00 70.74 ? 364 ALA C O 1 ATOM 3537 C CB . ALA C 1 40 ? 76.003 -50.608 6.323 1.00 69.58 ? 364 ALA C CB 1 ATOM 3538 N N . PRO C 1 41 ? 74.169 -49.910 3.222 1.00 70.17 ? 365 PRO C N 1 ATOM 3539 C CA . PRO C 1 41 ? 72.836 -49.948 2.599 1.00 69.89 ? 365 PRO C CA 1 ATOM 3540 C C . PRO C 1 41 ? 71.940 -51.122 3.018 1.00 69.42 ? 365 PRO C C 1 ATOM 3541 O O . PRO C 1 41 ? 72.215 -52.278 2.678 1.00 69.03 ? 365 PRO C O 1 ATOM 3542 C CB . PRO C 1 41 ? 73.144 -50.026 1.096 1.00 69.95 ? 365 PRO C CB 1 ATOM 3543 C CG . PRO C 1 41 ? 74.509 -49.464 0.959 1.00 70.11 ? 365 PRO C CG 1 ATOM 3544 C CD . PRO C 1 41 ? 75.234 -49.887 2.204 1.00 70.28 ? 365 PRO C CD 1 ATOM 3545 N N . SER C 1 42 ? 70.867 -50.800 3.738 1.00 68.70 ? 366 SER C N 1 ATOM 3546 C CA . SER C 1 42 ? 69.902 -51.787 4.217 1.00 67.94 ? 366 SER C CA 1 ATOM 3547 C C . SER C 1 42 ? 68.650 -51.787 3.350 1.00 67.20 ? 366 SER C C 1 ATOM 3548 O O . SER C 1 42 ? 68.259 -50.751 2.807 1.00 67.08 ? 366 SER C O 1 ATOM 3549 C CB . SER C 1 42 ? 69.483 -51.463 5.653 1.00 67.82 ? 366 SER C CB 1 ATOM 3550 O OG . SER C 1 42 ? 70.555 -50.899 6.388 1.00 67.91 ? 366 SER C OG 1 ATOM 3551 N N . LYS C 1 43 ? 68.016 -52.951 3.234 1.00 66.11 ? 367 LYS C N 1 ATOM 3552 C CA . LYS C 1 43 ? 66.688 -53.040 2.637 1.00 64.98 ? 367 LYS C CA 1 ATOM 3553 C C . LYS C 1 43 ? 65.769 -51.987 3.267 1.00 64.37 ? 367 LYS C C 1 ATOM 3554 O O . LYS C 1 43 ? 65.053 -52.274 4.231 1.00 64.99 ? 367 LYS C O 1 ATOM 3555 C CB . LYS C 1 43 ? 66.111 -54.447 2.843 1.00 64.52 ? 367 LYS C CB 1 ATOM 3556 C CG . LYS C 1 43 ? 64.803 -54.716 2.107 1.00 64.11 ? 367 LYS C CG 1 ATOM 3557 C CD . LYS C 1 43 ? 64.362 -56.172 2.252 1.00 63.44 ? 367 LYS C CD 1 ATOM 3558 C CE . LYS C 1 43 ? 63.059 -56.432 1.516 1.00 62.93 ? 367 LYS C CE 1 ATOM 3559 N NZ . LYS C 1 43 ? 62.699 -57.868 1.528 1.00 62.34 ? 367 LYS C NZ 1 ATOM 3560 N N . GLY C 1 44 ? 65.798 -50.767 2.731 1.00 62.50 ? 368 GLY C N 1 ATOM 3561 C CA . GLY C 1 44 ? 64.901 -49.711 3.196 1.00 61.25 ? 368 GLY C CA 1 ATOM 3562 C C . GLY C 1 44 ? 65.178 -48.349 2.585 1.00 59.97 ? 368 GLY C C 1 ATOM 3563 O O . GLY C 1 44 ? 66.334 -47.953 2.448 1.00 59.52 ? 368 GLY C O 1 ATOM 3564 N N . THR C 1 45 ? 64.116 -47.630 2.225 1.00 58.75 ? 369 THR C N 1 ATOM 3565 C CA . THR C 1 45 ? 64.239 -46.318 1.578 1.00 57.83 ? 369 THR C CA 1 ATOM 3566 C C . THR C 1 45 ? 64.295 -45.141 2.553 1.00 56.68 ? 369 THR C C 1 ATOM 3567 O O . THR C 1 45 ? 63.328 -44.862 3.273 1.00 54.97 ? 369 THR C O 1 ATOM 3568 C CB . THR C 1 45 ? 63.065 -46.021 0.619 1.00 57.86 ? 369 THR C CB 1 ATOM 3569 O OG1 . THR C 1 45 ? 63.315 -44.774 -0.046 1.00 57.32 ? 369 THR C OG1 1 ATOM 3570 C CG2 . THR C 1 45 ? 61.734 -45.928 1.379 1.00 57.40 ? 369 THR C CG2 1 ATOM 3571 N N . VAL C 1 46 ? 65.430 -44.447 2.544 1.00 55.75 ? 370 VAL C N 1 ATOM 3572 C CA . VAL C 1 46 ? 65.583 -43.210 3.301 1.00 55.13 ? 370 VAL C CA 1 ATOM 3573 C C . VAL C 1 46 ? 64.630 -42.161 2.760 1.00 54.58 ? 370 VAL C C 1 ATOM 3574 O O . VAL C 1 46 ? 64.417 -42.055 1.559 1.00 54.49 ? 370 VAL C O 1 ATOM 3575 C CB . VAL C 1 46 ? 67.009 -42.631 3.209 1.00 55.38 ? 370 VAL C CB 1 ATOM 3576 C CG1 . VAL C 1 46 ? 67.148 -41.427 4.131 1.00 55.41 ? 370 VAL C CG1 1 ATOM 3577 C CG2 . VAL C 1 46 ? 68.051 -43.688 3.550 1.00 55.47 ? 370 VAL C CG2 1 ATOM 3578 N N . GLN C 1 47 ? 64.057 -41.377 3.658 1.00 54.50 ? 371 GLN C N 1 ATOM 3579 C CA . GLN C 1 47 ? 63.094 -40.370 3.254 1.00 54.40 ? 371 GLN C CA 1 ATOM 3580 C C . GLN C 1 47 ? 63.547 -38.990 3.718 1.00 52.88 ? 371 GLN C C 1 ATOM 3581 O O . GLN C 1 47 ? 63.884 -38.796 4.887 1.00 51.53 ? 371 GLN C O 1 ATOM 3582 C CB . GLN C 1 47 ? 61.722 -40.704 3.830 1.00 55.42 ? 371 GLN C CB 1 ATOM 3583 C CG . GLN C 1 47 ? 60.594 -39.954 3.160 1.00 56.61 ? 371 GLN C CG 1 ATOM 3584 C CD . GLN C 1 47 ? 59.252 -40.288 3.766 1.00 57.76 ? 371 GLN C CD 1 ATOM 3585 O OE1 . GLN C 1 47 ? 59.159 -41.067 4.719 1.00 58.04 ? 371 GLN C OE1 1 ATOM 3586 N NE2 . GLN C 1 47 ? 58.199 -39.694 3.217 1.00 58.88 ? 371 GLN C NE2 1 ATOM 3587 N N . LEU C 1 48 ? 63.564 -38.043 2.783 1.00 51.80 ? 372 LEU C N 1 ATOM 3588 C CA . LEU C 1 48 ? 63.927 -36.659 3.072 1.00 49.88 ? 372 LEU C CA 1 ATOM 3589 C C . LEU C 1 48 ? 62.716 -35.759 2.899 1.00 47.28 ? 372 LEU C C 1 ATOM 3590 O O . LEU C 1 48 ? 62.148 -35.676 1.816 1.00 46.44 ? 372 LEU C O 1 ATOM 3591 C CB . LEU C 1 48 ? 65.059 -36.206 2.149 1.00 50.92 ? 372 LEU C CB 1 ATOM 3592 C CG . LEU C 1 48 ? 66.332 -37.053 2.255 1.00 52.24 ? 372 LEU C CG 1 ATOM 3593 C CD1 . LEU C 1 48 ? 67.565 -36.302 1.758 1.00 52.29 ? 372 LEU C CD1 1 ATOM 3594 C CD2 . LEU C 1 48 ? 66.531 -37.476 3.706 1.00 54.04 ? 372 LEU C CD2 1 ATOM 3595 N N . THR C 1 49 ? 62.322 -35.088 3.974 1.00 45.48 ? 373 THR C N 1 ATOM 3596 C CA . THR C 1 49 ? 61.178 -34.180 3.934 1.00 44.61 ? 373 THR C CA 1 ATOM 3597 C C . THR C 1 49 ? 61.603 -32.752 4.289 1.00 43.08 ? 373 THR C C 1 ATOM 3598 O O . THR C 1 49 ? 62.453 -32.537 5.160 1.00 43.54 ? 373 THR C O 1 ATOM 3599 C CB . THR C 1 49 ? 60.075 -34.656 4.904 1.00 44.74 ? 373 THR C CB 1 ATOM 3600 O OG1 . THR C 1 49 ? 59.727 -36.010 4.592 1.00 44.81 ? 373 THR C OG1 1 ATOM 3601 C CG2 . THR C 1 49 ? 58.822 -33.785 4.803 1.00 44.70 ? 373 THR C CG2 1 ATOM 3602 N N . TRP C 1 50 ? 61.000 -31.776 3.621 1.00 40.41 ? 374 TRP C N 1 ATOM 3603 C CA . TRP C 1 50 ? 61.375 -30.377 3.815 1.00 38.69 ? 374 TRP C CA 1 ATOM 3604 C C . TRP C 1 50 ? 60.290 -29.573 4.530 1.00 37.31 ? 374 TRP C C 1 ATOM 3605 O O . TRP C 1 50 ? 59.107 -29.907 4.463 1.00 38.28 ? 374 TRP C O 1 ATOM 3606 C CB . TRP C 1 50 ? 61.652 -29.726 2.459 1.00 37.84 ? 374 TRP C CB 1 ATOM 3607 C CG . TRP C 1 50 ? 62.862 -30.243 1.751 1.00 36.58 ? 374 TRP C CG 1 ATOM 3608 C CD1 . TRP C 1 50 ? 62.898 -31.142 0.718 1.00 36.48 ? 374 TRP C CD1 1 ATOM 3609 C CD2 . TRP C 1 50 ? 64.218 -29.882 2.012 1.00 36.15 ? 374 TRP C CD2 1 ATOM 3610 N NE1 . TRP C 1 50 ? 64.198 -31.351 0.323 1.00 36.40 ? 374 TRP C NE1 1 ATOM 3611 C CE2 . TRP C 1 50 ? 65.026 -30.589 1.104 1.00 35.13 ? 374 TRP C CE2 1 ATOM 3612 C CE3 . TRP C 1 50 ? 64.830 -29.029 2.926 1.00 35.86 ? 374 TRP C CE3 1 ATOM 3613 C CZ2 . TRP C 1 50 ? 66.403 -30.475 1.094 1.00 34.36 ? 374 TRP C CZ2 1 ATOM 3614 C CZ3 . TRP C 1 50 ? 66.204 -28.912 2.900 1.00 35.47 ? 374 TRP C CZ3 1 ATOM 3615 C CH2 . TRP C 1 50 ? 66.971 -29.632 1.996 1.00 34.04 ? 374 TRP C CH2 1 ATOM 3616 N N . SER C 1 51 ? 60.695 -28.507 5.212 1.00 36.46 ? 375 SER C N 1 ATOM 3617 C CA . SER C 1 51 ? 59.746 -27.489 5.696 1.00 36.02 ? 375 SER C CA 1 ATOM 3618 C C . SER C 1 51 ? 60.452 -26.155 5.959 1.00 34.78 ? 375 SER C C 1 ATOM 3619 O O . SER C 1 51 ? 61.682 -26.079 5.934 1.00 33.86 ? 375 SER C O 1 ATOM 3620 C CB . SER C 1 51 ? 59.052 -27.962 6.973 1.00 35.28 ? 375 SER C CB 1 ATOM 3621 O OG . SER C 1 51 ? 60.007 -28.158 8.003 1.00 35.43 ? 375 SER C OG 1 ATOM 3622 N N . ARG C 1 52 ? 59.671 -25.113 6.228 1.00 34.48 ? 376 ARG C N 1 ATOM 3623 C CA . ARG C 1 52 ? 60.209 -23.789 6.543 1.00 33.63 ? 376 ARG C CA 1 ATOM 3624 C C . ARG C 1 52 ? 59.888 -23.382 7.971 1.00 33.10 ? 376 ARG C C 1 ATOM 3625 O O . ARG C 1 52 ? 58.811 -23.709 8.463 1.00 34.29 ? 376 ARG C O 1 ATOM 3626 C CB . ARG C 1 52 ? 59.584 -22.740 5.637 1.00 33.94 ? 376 ARG C CB 1 ATOM 3627 C CG . ARG C 1 52 ? 59.963 -22.830 4.161 1.00 34.43 ? 376 ARG C CG 1 ATOM 3628 C CD . ARG C 1 52 ? 60.040 -21.416 3.584 1.00 34.64 ? 376 ARG C CD 1 ATOM 3629 N NE . ARG C 1 52 ? 59.368 -21.315 2.307 1.00 35.54 ? 376 ARG C NE 1 ATOM 3630 C CZ . ARG C 1 52 ? 59.060 -20.166 1.720 1.00 37.41 ? 376 ARG C CZ 1 ATOM 3631 N NH1 . ARG C 1 52 ? 59.369 -19.010 2.291 1.00 37.82 ? 376 ARG C NH1 1 ATOM 3632 N NH2 . ARG C 1 52 ? 58.440 -20.173 0.552 1.00 38.77 ? 376 ARG C NH2 1 ATOM 3633 N N . ALA C 1 53 ? 60.779 -22.647 8.634 1.00 31.50 ? 377 ALA C N 1 ATOM 3634 C CA . ALA C 1 53 ? 60.470 -22.196 9.998 1.00 31.20 ? 377 ALA C CA 1 ATOM 3635 C C . ALA C 1 53 ? 59.241 -21.299 10.005 1.00 31.27 ? 377 ALA C C 1 ATOM 3636 O O . ALA C 1 53 ? 58.460 -21.303 10.960 1.00 32.35 ? 377 ALA C O 1 ATOM 3637 C CB . ALA C 1 53 ? 61.653 -21.477 10.660 1.00 29.87 ? 377 ALA C CB 1 ATOM 3638 N N . SER C 1 54 ? 59.060 -20.543 8.934 1.00 31.26 ? 378 SER C N 1 ATOM 3639 C CA . SER C 1 54 ? 57.939 -19.625 8.859 1.00 31.99 ? 378 SER C CA 1 ATOM 3640 C C . SER C 1 54 ? 56.616 -20.369 8.649 1.00 33.26 ? 378 SER C C 1 ATOM 3641 O O . SER C 1 54 ? 55.545 -19.791 8.793 1.00 32.21 ? 378 SER C O 1 ATOM 3642 C CB . SER C 1 54 ? 58.186 -18.597 7.754 1.00 31.93 ? 378 SER C CB 1 ATOM 3643 O OG . SER C 1 54 ? 58.466 -19.220 6.519 1.00 31.11 ? 378 SER C OG 1 ATOM 3644 N N . GLY C 1 55 ? 56.695 -21.657 8.320 1.00 35.46 ? 379 GLY C N 1 ATOM 3645 C CA . GLY C 1 55 ? 55.504 -22.489 8.111 1.00 35.37 ? 379 GLY C CA 1 ATOM 3646 C C . GLY C 1 55 ? 55.018 -22.516 6.675 1.00 35.59 ? 379 GLY C C 1 ATOM 3647 O O . GLY C 1 55 ? 54.188 -23.344 6.315 1.00 35.04 ? 379 GLY C O 1 ATOM 3648 N N . LYS C 1 56 ? 55.547 -21.611 5.856 1.00 37.83 ? 380 LYS C N 1 ATOM 3649 C CA . LYS C 1 56 ? 55.211 -21.530 4.434 1.00 39.19 ? 380 LYS C CA 1 ATOM 3650 C C . LYS C 1 56 ? 55.657 -22.778 3.688 1.00 38.64 ? 380 LYS C C 1 ATOM 3651 O O . LYS C 1 56 ? 56.527 -23.513 4.158 1.00 39.58 ? 380 LYS C O 1 ATOM 3652 C CB . LYS C 1 56 ? 55.896 -20.315 3.800 1.00 40.58 ? 380 LYS C CB 1 ATOM 3653 C CG . LYS C 1 56 ? 55.538 -18.969 4.410 1.00 41.42 ? 380 LYS C CG 1 ATOM 3654 C CD . LYS C 1 56 ? 56.144 -17.868 3.543 1.00 43.04 ? 380 LYS C CD 1 ATOM 3655 C CE . LYS C 1 56 ? 56.370 -16.553 4.282 1.00 43.50 ? 380 LYS C CE 1 ATOM 3656 N NZ . LYS C 1 56 ? 57.087 -15.592 3.385 1.00 44.01 ? 380 LYS C NZ 1 ATOM 3657 N N . PRO C 1 57 ? 55.080 -23.005 2.504 1.00 39.42 ? 381 PRO C N 1 ATOM 3658 C CA . PRO C 1 57 ? 55.333 -24.229 1.754 1.00 38.97 ? 381 PRO C CA 1 ATOM 3659 C C . PRO C 1 57 ? 56.671 -24.219 1.069 1.00 39.71 ? 381 PRO C C 1 ATOM 3660 O O . PRO C 1 57 ? 57.194 -23.167 0.683 1.00 38.76 ? 381 PRO C O 1 ATOM 3661 C CB . PRO C 1 57 ? 54.249 -24.250 0.673 1.00 38.96 ? 381 PRO C CB 1 ATOM 3662 C CG . PRO C 1 57 ? 53.496 -22.971 0.803 1.00 39.87 ? 381 PRO C CG 1 ATOM 3663 C CD . PRO C 1 57 ? 54.222 -22.070 1.758 1.00 39.91 ? 381 PRO C CD 1 ATOM 3664 N N . VAL C 1 58 ? 57.201 -25.422 0.910 1.00 40.10 ? 382 VAL C N 1 ATOM 3665 C CA . VAL C 1 58 ? 58.427 -25.628 0.188 1.00 39.85 ? 382 VAL C CA 1 ATOM 3666 C C . VAL C 1 58 ? 58.030 -26.080 -1.208 1.00 41.55 ? 382 VAL C C 1 ATOM 3667 O O . VAL C 1 58 ? 56.969 -26.674 -1.383 1.00 42.01 ? 382 VAL C O 1 ATOM 3668 C CB . VAL C 1 58 ? 59.280 -26.695 0.894 1.00 40.11 ? 382 VAL C CB 1 ATOM 3669 C CG1 . VAL C 1 58 ? 59.523 -26.291 2.358 1.00 39.87 ? 382 VAL C CG1 1 ATOM 3670 C CG2 . VAL C 1 58 ? 58.600 -28.071 0.834 1.00 39.40 ? 382 VAL C CG2 1 ATOM 3671 N N . GLN C 1 59 ? 58.867 -25.779 -2.197 1.00 42.97 ? 383 GLN C N 1 ATOM 3672 C CA . GLN C 1 59 ? 58.692 -26.303 -3.553 1.00 44.66 ? 383 GLN C CA 1 ATOM 3673 C C . GLN C 1 59 ? 58.962 -27.809 -3.673 1.00 42.05 ? 383 GLN C C 1 ATOM 3674 O O . GLN C 1 59 ? 59.271 -28.475 -2.680 1.00 40.51 ? 383 GLN C O 1 ATOM 3675 C CB . GLN C 1 59 ? 59.558 -25.510 -4.528 1.00 46.99 ? 383 GLN C CB 1 ATOM 3676 C CG . GLN C 1 59 ? 59.087 -24.066 -4.661 1.00 50.32 ? 383 GLN C CG 1 ATOM 3677 C CD . GLN C 1 59 ? 60.017 -23.253 -5.523 1.00 53.55 ? 383 GLN C CD 1 ATOM 3678 O OE1 . GLN C 1 59 ? 60.378 -23.680 -6.620 1.00 57.30 ? 383 GLN C OE1 1 ATOM 3679 N NE2 . GLN C 1 59 ? 60.423 -22.081 -5.039 1.00 56.02 ? 383 GLN C NE2 1 ATOM 3680 N N . HIS C 1 60 ? 58.795 -28.337 -4.886 1.00 40.06 ? 384 HIS C N 1 ATOM 3681 C CA . HIS C 1 60 ? 59.175 -29.716 -5.215 1.00 38.40 ? 384 HIS C CA 1 ATOM 3682 C C . HIS C 1 60 ? 60.690 -29.908 -5.255 1.00 37.93 ? 384 HIS C C 1 ATOM 3683 O O . HIS C 1 60 ? 61.399 -29.145 -5.903 1.00 36.15 ? 384 HIS C O 1 ATOM 3684 C CB . HIS C 1 60 ? 58.632 -30.112 -6.587 1.00 37.64 ? 384 HIS C CB 1 ATOM 3685 C CG . HIS C 1 60 ? 58.973 -31.516 -6.980 1.00 38.01 ? 384 HIS C CG 1 ATOM 3686 N ND1 . HIS C 1 60 ? 58.157 -32.589 -6.684 1.00 37.68 ? 384 HIS C ND1 1 ATOM 3687 C CD2 . HIS C 1 60 ? 60.039 -32.026 -7.647 1.00 37.72 ? 384 HIS C CD2 1 ATOM 3688 C CE1 . HIS C 1 60 ? 58.704 -33.698 -7.154 1.00 37.21 ? 384 HIS C CE1 1 ATOM 3689 N NE2 . HIS C 1 60 ? 59.846 -33.385 -7.741 1.00 36.89 ? 384 HIS C NE2 1 ATOM 3690 N N . SER C 1 61 ? 61.160 -30.957 -4.593 1.00 38.17 ? 385 SER C N 1 ATOM 3691 C CA . SER C 1 61 ? 62.580 -31.239 -4.464 1.00 39.57 ? 385 SER C CA 1 ATOM 3692 C C . SER C 1 61 ? 63.007 -32.479 -5.273 1.00 38.84 ? 385 SER C C 1 ATOM 3693 O O . SER C 1 61 ? 62.175 -33.317 -5.612 1.00 39.47 ? 385 SER C O 1 ATOM 3694 C CB . SER C 1 61 ? 62.915 -31.428 -2.977 1.00 39.31 ? 385 SER C CB 1 ATOM 3695 O OG . SER C 1 61 ? 62.308 -32.595 -2.463 1.00 38.57 ? 385 SER C OG 1 ATOM 3696 N N . THR C 1 62 ? 64.300 -32.595 -5.573 1.00 36.95 ? 386 THR C N 1 ATOM 3697 C CA . THR C 1 62 ? 64.800 -33.659 -6.451 1.00 36.29 ? 386 THR C CA 1 ATOM 3698 C C . THR C 1 62 ? 65.642 -34.666 -5.687 1.00 38.00 ? 386 THR C C 1 ATOM 3699 O O . THR C 1 62 ? 66.621 -34.319 -5.043 1.00 38.20 ? 386 THR C O 1 ATOM 3700 C CB . THR C 1 62 ? 65.705 -33.116 -7.570 1.00 34.86 ? 386 THR C CB 1 ATOM 3701 O OG1 . THR C 1 62 ? 64.970 -32.173 -8.350 1.00 35.02 ? 386 THR C OG1 1 ATOM 3702 C CG2 . THR C 1 62 ? 66.165 -34.254 -8.482 1.00 34.14 ? 386 THR C CG2 1 ATOM 3703 N N . ARG C 1 63 ? 65.265 -35.929 -5.780 1.00 40.42 ? 387 ARG C N 1 ATOM 3704 C CA . ARG C 1 63 ? 65.906 -36.969 -5.004 1.00 42.96 ? 387 ARG C CA 1 ATOM 3705 C C . ARG C 1 63 ? 66.883 -37.700 -5.916 1.00 44.49 ? 387 ARG C C 1 ATOM 3706 O O . ARG C 1 63 ? 66.595 -37.929 -7.091 1.00 44.59 ? 387 ARG C O 1 ATOM 3707 C CB . ARG C 1 63 ? 64.835 -37.923 -4.462 1.00 44.25 ? 387 ARG C CB 1 ATOM 3708 C CG . ARG C 1 63 ? 65.348 -39.080 -3.611 1.00 44.80 ? 387 ARG C CG 1 ATOM 3709 C CD . ARG C 1 63 ? 64.446 -40.302 -3.740 1.00 45.70 ? 387 ARG C CD 1 ATOM 3710 N NE . ARG C 1 63 ? 64.989 -41.439 -2.998 1.00 46.93 ? 387 ARG C NE 1 ATOM 3711 C CZ . ARG C 1 63 ? 64.941 -41.556 -1.673 1.00 46.86 ? 387 ARG C CZ 1 ATOM 3712 N NH1 . ARG C 1 63 ? 64.365 -40.608 -0.953 1.00 46.59 ? 387 ARG C NH1 1 ATOM 3713 N NH2 . ARG C 1 63 ? 65.462 -42.616 -1.068 1.00 46.57 ? 387 ARG C NH2 1 ATOM 3714 N N . LYS C 1 64 ? 68.036 -38.071 -5.376 1.00 46.06 ? 388 LYS C N 1 ATOM 3715 C CA . LYS C 1 64 ? 69.095 -38.644 -6.195 1.00 48.41 ? 388 LYS C CA 1 ATOM 3716 C C . LYS C 1 64 ? 69.854 -39.715 -5.421 1.00 49.86 ? 388 LYS C C 1 ATOM 3717 O O . LYS C 1 64 ? 70.406 -39.446 -4.352 1.00 50.43 ? 388 LYS C O 1 ATOM 3718 C CB . LYS C 1 64 ? 70.047 -37.533 -6.649 1.00 49.22 ? 388 LYS C CB 1 ATOM 3719 C CG . LYS C 1 64 ? 71.340 -38.003 -7.282 1.00 49.84 ? 388 LYS C CG 1 ATOM 3720 C CD . LYS C 1 64 ? 71.097 -38.652 -8.633 1.00 49.89 ? 388 LYS C CD 1 ATOM 3721 C CE . LYS C 1 64 ? 72.410 -39.010 -9.309 1.00 49.64 ? 388 LYS C CE 1 ATOM 3722 N NZ . LYS C 1 64 ? 72.155 -39.680 -10.609 1.00 49.72 ? 388 LYS C NZ 1 ATOM 3723 N N . GLU C 1 65 ? 69.872 -40.930 -5.962 1.00 50.95 ? 389 GLU C N 1 ATOM 3724 C CA . GLU C 1 65 ? 70.538 -42.056 -5.317 1.00 51.79 ? 389 GLU C CA 1 ATOM 3725 C C . GLU C 1 65 ? 71.747 -42.488 -6.150 1.00 53.19 ? 389 GLU C C 1 ATOM 3726 O O . GLU C 1 65 ? 71.632 -42.682 -7.361 1.00 53.43 ? 389 GLU C O 1 ATOM 3727 C CB . GLU C 1 65 ? 69.582 -43.240 -5.195 1.00 51.99 ? 389 GLU C CB 1 ATOM 3728 C CG . GLU C 1 65 ? 68.428 -43.064 -4.230 1.00 52.56 ? 389 GLU C CG 1 ATOM 3729 C CD . GLU C 1 65 ? 67.715 -44.384 -3.929 1.00 53.22 ? 389 GLU C CD 1 ATOM 3730 O OE1 . GLU C 1 65 ? 68.373 -45.449 -3.966 1.00 53.76 ? 389 GLU C OE1 1 ATOM 3731 O OE2 . GLU C 1 65 ? 66.497 -44.367 -3.651 1.00 52.88 ? 389 GLU C OE2 1 ATOM 3732 N N . GLU C 1 66 ? 72.903 -42.634 -5.509 1.00 53.95 ? 390 GLU C N 1 ATOM 3733 C CA . GLU C 1 66 ? 74.084 -43.150 -6.180 1.00 54.97 ? 390 GLU C CA 1 ATOM 3734 C C . GLU C 1 66 ? 74.964 -43.988 -5.251 1.00 54.51 ? 390 GLU C C 1 ATOM 3735 O O . GLU C 1 66 ? 75.441 -43.520 -4.210 1.00 52.83 ? 390 GLU C O 1 ATOM 3736 C CB . GLU C 1 66 ? 74.876 -42.028 -6.864 1.00 56.86 ? 390 GLU C CB 1 ATOM 3737 C CG . GLU C 1 66 ? 75.436 -40.939 -5.957 1.00 58.83 ? 390 GLU C CG 1 ATOM 3738 C CD . GLU C 1 66 ? 76.431 -40.009 -6.680 1.00 60.75 ? 390 GLU C CD 1 ATOM 3739 O OE1 . GLU C 1 66 ? 76.346 -39.881 -7.932 1.00 61.04 ? 390 GLU C OE1 1 ATOM 3740 O OE2 . GLU C 1 66 ? 77.303 -39.411 -5.994 1.00 61.55 ? 390 GLU C OE2 1 ATOM 3741 N N . LYS C 1 67 ? 75.158 -45.244 -5.650 1.00 54.26 ? 391 LYS C N 1 ATOM 3742 C CA . LYS C 1 67 ? 76.064 -46.140 -4.953 1.00 54.54 ? 391 LYS C CA 1 ATOM 3743 C C . LYS C 1 67 ? 77.488 -45.705 -5.245 1.00 54.72 ? 391 LYS C C 1 ATOM 3744 O O . LYS C 1 67 ? 77.799 -45.264 -6.351 1.00 54.76 ? 391 LYS C O 1 ATOM 3745 C CB . LYS C 1 67 ? 75.858 -47.585 -5.401 1.00 54.74 ? 391 LYS C CB 1 ATOM 3746 C CG . LYS C 1 67 ? 76.860 -48.573 -4.808 1.00 54.91 ? 391 LYS C CG 1 ATOM 3747 C CD . LYS C 1 67 ? 76.491 -49.998 -5.191 1.00 54.84 ? 391 LYS C CD 1 ATOM 3748 C CE . LYS C 1 67 ? 77.636 -50.974 -4.982 1.00 54.84 ? 391 LYS C CE 1 ATOM 3749 N NZ . LYS C 1 67 ? 77.334 -52.289 -5.620 1.00 54.32 ? 391 LYS C NZ 1 ATOM 3750 N N . GLN C 1 68 ? 78.348 -45.820 -4.242 1.00 55.23 ? 392 GLN C N 1 ATOM 3751 C CA . GLN C 1 68 ? 79.726 -45.392 -4.379 1.00 55.84 ? 392 GLN C CA 1 ATOM 3752 C C . GLN C 1 68 ? 80.591 -46.630 -4.514 1.00 57.04 ? 392 GLN C C 1 ATOM 3753 O O . GLN C 1 68 ? 80.089 -47.759 -4.479 1.00 57.87 ? 392 GLN C O 1 ATOM 3754 C CB . GLN C 1 68 ? 80.160 -44.555 -3.171 1.00 55.65 ? 392 GLN C CB 1 ATOM 3755 C CG . GLN C 1 68 ? 79.262 -43.354 -2.875 1.00 54.76 ? 392 GLN C CG 1 ATOM 3756 C CD . GLN C 1 68 ? 79.266 -42.306 -3.977 1.00 54.39 ? 392 GLN C CD 1 ATOM 3757 O OE1 . GLN C 1 68 ? 80.307 -41.998 -4.560 1.00 52.93 ? 392 GLN C OE1 1 ATOM 3758 N NE2 . GLN C 1 68 ? 78.094 -41.737 -4.253 1.00 54.65 ? 392 GLN C NE2 1 ATOM 3759 N N . ARG C 1 69 ? 81.891 -46.413 -4.677 1.00 58.06 ? 393 ARG C N 1 ATOM 3760 C CA . ARG C 1 69 ? 82.824 -47.510 -4.909 1.00 58.93 ? 393 ARG C CA 1 ATOM 3761 C C . ARG C 1 69 ? 83.042 -48.341 -3.650 1.00 58.18 ? 393 ARG C C 1 ATOM 3762 O O . ARG C 1 69 ? 83.150 -49.566 -3.723 1.00 57.54 ? 393 ARG C O 1 ATOM 3763 C CB . ARG C 1 69 ? 84.159 -46.962 -5.417 1.00 60.23 ? 393 ARG C CB 1 ATOM 3764 C CG . ARG C 1 69 ? 84.041 -46.250 -6.754 1.00 61.43 ? 393 ARG C CG 1 ATOM 3765 C CD . ARG C 1 69 ? 85.398 -45.963 -7.364 1.00 62.44 ? 393 ARG C CD 1 ATOM 3766 N NE . ARG C 1 69 ? 85.265 -45.429 -8.717 1.00 63.69 ? 393 ARG C NE 1 ATOM 3767 C CZ . ARG C 1 69 ? 86.272 -45.312 -9.580 1.00 64.78 ? 393 ARG C CZ 1 ATOM 3768 N NH1 . ARG C 1 69 ? 87.501 -45.689 -9.243 1.00 65.04 ? 393 ARG C NH1 1 ATOM 3769 N NH2 . ARG C 1 69 ? 86.049 -44.813 -10.788 1.00 65.15 ? 393 ARG C NH2 1 ATOM 3770 N N . ASN C 1 70 ? 83.094 -47.662 -2.504 1.00 57.55 ? 394 ASN C N 1 ATOM 3771 C CA . ASN C 1 70 ? 83.371 -48.303 -1.220 1.00 56.65 ? 394 ASN C CA 1 ATOM 3772 C C . ASN C 1 70 ? 82.167 -49.041 -0.633 1.00 55.58 ? 394 ASN C C 1 ATOM 3773 O O . ASN C 1 70 ? 82.227 -49.535 0.495 1.00 54.91 ? 394 ASN C O 1 ATOM 3774 C CB . ASN C 1 70 ? 83.925 -47.280 -0.218 1.00 57.11 ? 394 ASN C CB 1 ATOM 3775 C CG . ASN C 1 70 ? 83.035 -46.051 -0.061 1.00 57.50 ? 394 ASN C CG 1 ATOM 3776 O OD1 . ASN C 1 70 ? 82.012 -45.919 -0.732 1.00 56.95 ? 394 ASN C OD1 1 ATOM 3777 N ND2 . ASN C 1 70 ? 83.435 -45.145 0.839 1.00 58.48 ? 394 ASN C ND2 1 ATOM 3778 N N . GLY C 1 71 ? 81.085 -49.121 -1.405 1.00 54.66 ? 395 GLY C N 1 ATOM 3779 C CA . GLY C 1 71 ? 79.918 -49.909 -1.024 1.00 54.45 ? 395 GLY C CA 1 ATOM 3780 C C . GLY C 1 71 ? 78.871 -49.135 -0.243 1.00 54.16 ? 395 GLY C C 1 ATOM 3781 O O . GLY C 1 71 ? 77.889 -49.714 0.221 1.00 53.97 ? 395 GLY C O 1 ATOM 3782 N N . THR C 1 72 ? 79.074 -47.828 -0.095 1.00 53.73 ? 396 THR C N 1 ATOM 3783 C CA . THR C 1 72 ? 78.104 -46.987 0.600 1.00 53.74 ? 396 THR C CA 1 ATOM 3784 C C . THR C 1 72 ? 77.013 -46.542 -0.372 1.00 53.66 ? 396 THR C C 1 ATOM 3785 O O . THR C 1 72 ? 77.157 -46.710 -1.587 1.00 53.17 ? 396 THR C O 1 ATOM 3786 C CB . THR C 1 72 ? 78.779 -45.760 1.258 1.00 53.62 ? 396 THR C CB 1 ATOM 3787 O OG1 . THR C 1 72 ? 79.192 -44.827 0.256 1.00 53.67 ? 396 THR C OG1 1 ATOM 3788 C CG2 . THR C 1 72 ? 79.994 -46.182 2.075 1.00 54.07 ? 396 THR C CG2 1 ATOM 3789 N N . LEU C 1 73 ? 75.923 -45.997 0.171 1.00 53.72 ? 397 LEU C N 1 ATOM 3790 C CA . LEU C 1 73 ? 74.840 -45.424 -0.639 1.00 53.72 ? 397 LEU C CA 1 ATOM 3791 C C . LEU C 1 73 ? 74.612 -43.959 -0.277 1.00 52.85 ? 397 LEU C C 1 ATOM 3792 O O . LEU C 1 73 ? 74.213 -43.650 0.848 1.00 54.24 ? 397 LEU C O 1 ATOM 3793 C CB . LEU C 1 73 ? 73.527 -46.202 -0.443 1.00 54.21 ? 397 LEU C CB 1 ATOM 3794 C CG . LEU C 1 73 ? 72.253 -45.690 -1.143 1.00 54.14 ? 397 LEU C CG 1 ATOM 3795 C CD1 . LEU C 1 73 ? 72.420 -45.650 -2.658 1.00 54.33 ? 397 LEU C CD1 1 ATOM 3796 C CD2 . LEU C 1 73 ? 71.037 -46.538 -0.786 1.00 53.78 ? 397 LEU C CD2 1 ATOM 3797 N N . THR C 1 74 ? 74.856 -43.059 -1.229 1.00 51.41 ? 398 THR C N 1 ATOM 3798 C CA . THR C 1 74 ? 74.537 -41.637 -1.046 1.00 49.24 ? 398 THR C CA 1 ATOM 3799 C C . THR C 1 74 ? 73.124 -41.287 -1.532 1.00 47.04 ? 398 THR C C 1 ATOM 3800 O O . THR C 1 74 ? 72.740 -41.616 -2.649 1.00 45.28 ? 398 THR C O 1 ATOM 3801 C CB . THR C 1 74 ? 75.531 -40.735 -1.793 1.00 49.52 ? 398 THR C CB 1 ATOM 3802 O OG1 . THR C 1 74 ? 76.780 -40.699 -1.091 1.00 49.86 ? 398 THR C OG1 1 ATOM 3803 C CG2 . THR C 1 74 ? 74.987 -39.327 -1.886 1.00 50.34 ? 398 THR C CG2 1 ATOM 3804 N N . VAL C 1 75 ? 72.349 -40.612 -0.689 1.00 45.10 ? 399 VAL C N 1 ATOM 3805 C CA . VAL C 1 75 ? 71.046 -40.095 -1.093 1.00 42.76 ? 399 VAL C CA 1 ATOM 3806 C C . VAL C 1 75 ? 70.964 -38.602 -0.810 1.00 41.52 ? 399 VAL C C 1 ATOM 3807 O O . VAL C 1 75 ? 71.189 -38.165 0.321 1.00 43.06 ? 399 VAL C O 1 ATOM 3808 C CB . VAL C 1 75 ? 69.925 -40.800 -0.343 1.00 42.38 ? 399 VAL C CB 1 ATOM 3809 C CG1 . VAL C 1 75 ? 68.574 -40.427 -0.929 1.00 42.35 ? 399 VAL C CG1 1 ATOM 3810 C CG2 . VAL C 1 75 ? 70.137 -42.295 -0.418 1.00 43.10 ? 399 VAL C CG2 1 ATOM 3811 N N . THR C 1 76 ? 70.638 -37.824 -1.837 1.00 38.26 ? 400 THR C N 1 ATOM 3812 C CA . THR C 1 76 ? 70.549 -36.383 -1.707 1.00 35.10 ? 400 THR C CA 1 ATOM 3813 C C . THR C 1 76 ? 69.145 -35.935 -2.080 1.00 34.41 ? 400 THR C C 1 ATOM 3814 O O . THR C 1 76 ? 68.468 -36.647 -2.815 1.00 35.16 ? 400 THR C O 1 ATOM 3815 C CB . THR C 1 76 ? 71.490 -35.662 -2.670 1.00 34.05 ? 400 THR C CB 1 ATOM 3816 O OG1 . THR C 1 76 ? 71.046 -35.905 -4.008 1.00 34.59 ? 400 THR C OG1 1 ATOM 3817 C CG2 . THR C 1 76 ? 72.925 -36.113 -2.512 1.00 33.34 ? 400 THR C CG2 1 ATOM 3818 N N . SER C 1 77 ? 68.721 -34.766 -1.583 1.00 31.93 ? 401 SER C N 1 ATOM 3819 C CA . SER C 1 77 ? 67.479 -34.134 -2.022 1.00 31.68 ? 401 SER C CA 1 ATOM 3820 C C . SER C 1 77 ? 67.748 -32.666 -2.261 1.00 32.70 ? 401 SER C C 1 ATOM 3821 O O . SER C 1 77 ? 68.377 -32.008 -1.439 1.00 34.98 ? 401 SER C O 1 ATOM 3822 C CB . SER C 1 77 ? 66.374 -34.266 -0.976 1.00 32.00 ? 401 SER C CB 1 ATOM 3823 O OG . SER C 1 77 ? 65.209 -33.534 -1.346 1.00 29.31 ? 401 SER C OG 1 ATOM 3824 N N . THR C 1 78 ? 67.301 -32.141 -3.391 1.00 33.24 ? 402 THR C N 1 ATOM 3825 C CA . THR C 1 78 ? 67.682 -30.784 -3.738 1.00 35.48 ? 402 THR C CA 1 ATOM 3826 C C . THR C 1 78 ? 66.441 -29.926 -3.854 1.00 35.94 ? 402 THR C C 1 ATOM 3827 O O . THR C 1 78 ? 65.564 -30.186 -4.679 1.00 39.38 ? 402 THR C O 1 ATOM 3828 C CB . THR C 1 78 ? 68.541 -30.723 -5.006 1.00 35.99 ? 402 THR C CB 1 ATOM 3829 O OG1 . THR C 1 78 ? 69.809 -31.311 -4.709 1.00 36.99 ? 402 THR C OG1 1 ATOM 3830 C CG2 . THR C 1 78 ? 68.794 -29.283 -5.436 1.00 36.92 ? 402 THR C CG2 1 ATOM 3831 N N . LEU C 1 79 ? 66.371 -28.922 -2.989 1.00 34.99 ? 403 LEU C N 1 ATOM 3832 C CA . LEU C 1 79 ? 65.190 -28.078 -2.857 1.00 34.35 ? 403 LEU C CA 1 ATOM 3833 C C . LEU C 1 79 ? 65.472 -26.725 -3.465 1.00 34.76 ? 403 LEU C C 1 ATOM 3834 O O . LEU C 1 79 ? 66.378 -26.041 -3.011 1.00 34.96 ? 403 LEU C O 1 ATOM 3835 C CB . LEU C 1 79 ? 64.876 -27.840 -1.378 1.00 33.21 ? 403 LEU C CB 1 ATOM 3836 C CG . LEU C 1 79 ? 63.640 -26.974 -1.103 1.00 31.57 ? 403 LEU C CG 1 ATOM 3837 C CD1 . LEU C 1 79 ? 62.422 -27.693 -1.670 1.00 28.35 ? 403 LEU C CD1 1 ATOM 3838 C CD2 . LEU C 1 79 ? 63.493 -26.679 0.403 1.00 28.00 ? 403 LEU C CD2 1 ATOM 3839 N N . PRO C 1 80 ? 64.711 -26.333 -4.496 1.00 35.69 ? 404 PRO C N 1 ATOM 3840 C CA . PRO C 1 80 ? 64.814 -24.948 -4.972 1.00 35.34 ? 404 PRO C CA 1 ATOM 3841 C C . PRO C 1 80 ? 64.291 -23.988 -3.910 1.00 34.37 ? 404 PRO C C 1 ATOM 3842 O O . PRO C 1 80 ? 63.302 -24.314 -3.271 1.00 34.84 ? 404 PRO C O 1 ATOM 3843 C CB . PRO C 1 80 ? 63.918 -24.927 -6.217 1.00 34.49 ? 404 PRO C CB 1 ATOM 3844 C CG . PRO C 1 80 ? 63.857 -26.367 -6.628 1.00 35.49 ? 404 PRO C CG 1 ATOM 3845 C CD . PRO C 1 80 ? 63.873 -27.160 -5.372 1.00 34.38 ? 404 PRO C CD 1 ATOM 3846 N N . VAL C 1 81 ? 64.938 -22.831 -3.722 1.00 33.75 ? 405 VAL C N 1 ATOM 3847 C CA . VAL C 1 81 ? 64.468 -21.832 -2.746 1.00 32.30 ? 405 VAL C CA 1 ATOM 3848 C C . VAL C 1 81 ? 64.393 -20.445 -3.359 1.00 31.42 ? 405 VAL C C 1 ATOM 3849 O O . VAL C 1 81 ? 64.949 -20.194 -4.428 1.00 30.00 ? 405 VAL C O 1 ATOM 3850 C CB . VAL C 1 81 ? 65.326 -21.801 -1.439 1.00 32.85 ? 405 VAL C CB 1 ATOM 3851 C CG1 . VAL C 1 81 ? 65.285 -23.141 -0.740 1.00 32.47 ? 405 VAL C CG1 1 ATOM 3852 C CG2 . VAL C 1 81 ? 66.770 -21.388 -1.669 1.00 31.93 ? 405 VAL C CG2 1 ATOM 3853 N N . GLY C 1 82 ? 63.660 -19.557 -2.692 1.00 32.91 ? 406 GLY C N 1 ATOM 3854 C CA . GLY C 1 82 ? 63.416 -18.215 -3.185 1.00 32.68 ? 406 GLY C CA 1 ATOM 3855 C C . GLY C 1 82 ? 64.619 -17.347 -2.879 1.00 34.48 ? 406 GLY C C 1 ATOM 3856 O O . GLY C 1 82 ? 65.226 -17.449 -1.809 1.00 34.95 ? 406 GLY C O 1 ATOM 3857 N N . THR C 1 83 ? 64.968 -16.486 -3.824 1.00 35.88 ? 407 THR C N 1 ATOM 3858 C CA . THR C 1 83 ? 66.068 -15.552 -3.639 1.00 37.50 ? 407 THR C CA 1 ATOM 3859 C C . THR C 1 83 ? 65.816 -14.619 -2.451 1.00 37.69 ? 407 THR C C 1 ATOM 3860 O O . THR C 1 83 ? 66.660 -14.492 -1.566 1.00 36.55 ? 407 THR C O 1 ATOM 3861 C CB . THR C 1 83 ? 66.265 -14.726 -4.910 1.00 38.72 ? 407 THR C CB 1 ATOM 3862 O OG1 . THR C 1 83 ? 66.599 -15.617 -5.980 1.00 40.96 ? 407 THR C OG1 1 ATOM 3863 C CG2 . THR C 1 83 ? 67.389 -13.716 -4.734 1.00 40.92 ? 407 THR C CG2 1 ATOM 3864 N N . ARG C 1 84 ? 64.656 -13.978 -2.430 1.00 38.26 ? 408 ARG C N 1 ATOM 3865 C CA . ARG C 1 84 ? 64.330 -13.055 -1.363 1.00 40.39 ? 408 ARG C CA 1 ATOM 3866 C C . ARG C 1 84 ? 64.204 -13.804 -0.039 1.00 38.07 ? 408 ARG C C 1 ATOM 3867 O O . ARG C 1 84 ? 64.750 -13.367 0.977 1.00 36.07 ? 408 ARG C O 1 ATOM 3868 C CB . ARG C 1 84 ? 63.036 -12.295 -1.678 1.00 43.89 ? 408 ARG C CB 1 ATOM 3869 C CG . ARG C 1 84 ? 62.621 -11.325 -0.570 1.00 47.84 ? 408 ARG C CG 1 ATOM 3870 C CD . ARG C 1 84 ? 61.368 -10.518 -0.914 1.00 50.42 ? 408 ARG C CD 1 ATOM 3871 N NE . ARG C 1 84 ? 61.561 -9.791 -2.166 1.00 53.72 ? 408 ARG C NE 1 ATOM 3872 C CZ . ARG C 1 84 ? 62.194 -8.624 -2.285 1.00 55.66 ? 408 ARG C CZ 1 ATOM 3873 N NH1 . ARG C 1 84 ? 62.707 -8.011 -1.220 1.00 55.94 ? 408 ARG C NH1 1 ATOM 3874 N NH2 . ARG C 1 84 ? 62.309 -8.062 -3.485 1.00 56.09 ? 408 ARG C NH2 1 ATOM 3875 N N . ASP C 1 85 ? 63.489 -14.926 -0.054 1.00 36.77 ? 409 ASP C N 1 ATOM 3876 C CA . ASP C 1 85 ? 63.258 -15.703 1.161 1.00 35.60 ? 409 ASP C CA 1 ATOM 3877 C C . ASP C 1 85 ? 64.580 -16.015 1.830 1.00 33.77 ? 409 ASP C C 1 ATOM 3878 O O . ASP C 1 85 ? 64.738 -15.821 3.029 1.00 31.12 ? 409 ASP C O 1 ATOM 3879 C CB . ASP C 1 85 ? 62.570 -17.027 0.845 1.00 37.46 ? 409 ASP C CB 1 ATOM 3880 C CG . ASP C 1 85 ? 61.157 -16.847 0.341 1.00 38.30 ? 409 ASP C CG 1 ATOM 3881 O OD1 . ASP C 1 85 ? 60.537 -15.825 0.697 1.00 39.72 ? 409 ASP C OD1 1 ATOM 3882 O OD2 . ASP C 1 85 ? 60.671 -17.731 -0.402 1.00 39.23 ? 409 ASP C OD2 1 ATOM 3883 N N . TRP C 1 86 ? 65.528 -16.501 1.037 1.00 32.89 ? 410 TRP C N 1 ATOM 3884 C CA . TRP C 1 86 ? 66.802 -16.957 1.571 1.00 32.37 ? 410 TRP C CA 1 ATOM 3885 C C . TRP C 1 86 ? 67.633 -15.799 2.103 1.00 34.56 ? 410 TRP C C 1 ATOM 3886 O O . TRP C 1 86 ? 68.212 -15.882 3.202 1.00 35.44 ? 410 TRP C O 1 ATOM 3887 C CB . TRP C 1 86 ? 67.628 -17.696 0.519 1.00 32.07 ? 410 TRP C CB 1 ATOM 3888 C CG . TRP C 1 86 ? 68.969 -17.972 1.087 1.00 32.28 ? 410 TRP C CG 1 ATOM 3889 C CD1 . TRP C 1 86 ? 70.073 -17.173 1.002 1.00 31.30 ? 410 TRP C CD1 1 ATOM 3890 C CD2 . TRP C 1 86 ? 69.345 -19.101 1.885 1.00 32.78 ? 410 TRP C CD2 1 ATOM 3891 N NE1 . TRP C 1 86 ? 71.110 -17.739 1.696 1.00 32.48 ? 410 TRP C NE1 1 ATOM 3892 C CE2 . TRP C 1 86 ? 70.690 -18.919 2.252 1.00 31.62 ? 410 TRP C CE2 1 ATOM 3893 C CE3 . TRP C 1 86 ? 68.669 -20.244 2.334 1.00 34.44 ? 410 TRP C CE3 1 ATOM 3894 C CZ2 . TRP C 1 86 ? 71.380 -19.836 3.034 1.00 32.52 ? 410 TRP C CZ2 1 ATOM 3895 C CZ3 . TRP C 1 86 ? 69.355 -21.160 3.111 1.00 34.03 ? 410 TRP C CZ3 1 ATOM 3896 C CH2 . TRP C 1 86 ? 70.702 -20.951 3.451 1.00 33.73 ? 410 TRP C CH2 1 ATOM 3897 N N . ILE C 1 87 ? 67.710 -14.737 1.301 1.00 33.62 ? 411 ILE C N 1 ATOM 3898 C CA . ILE C 1 87 ? 68.398 -13.522 1.684 1.00 33.60 ? 411 ILE C CA 1 ATOM 3899 C C . ILE C 1 87 ? 67.808 -12.890 2.942 1.00 32.38 ? 411 ILE C C 1 ATOM 3900 O O . ILE C 1 87 ? 68.541 -12.360 3.771 1.00 32.35 ? 411 ILE C O 1 ATOM 3901 C CB . ILE C 1 87 ? 68.431 -12.488 0.520 1.00 34.83 ? 411 ILE C CB 1 ATOM 3902 C CG1 . ILE C 1 87 ? 69.305 -12.997 -0.634 1.00 36.27 ? 411 ILE C CG1 1 ATOM 3903 C CG2 . ILE C 1 87 ? 69.064 -11.186 0.962 1.00 33.60 ? 411 ILE C CG2 1 ATOM 3904 C CD1 . ILE C 1 87 ? 70.805 -12.856 -0.352 1.00 36.28 ? 411 ILE C CD1 1 ATOM 3905 N N . GLU C 1 88 ? 66.496 -12.934 3.102 1.00 32.78 ? 412 GLU C N 1 ATOM 3906 C CA . GLU C 1 88 ? 65.876 -12.227 4.223 1.00 33.26 ? 412 GLU C CA 1 ATOM 3907 C C . GLU C 1 88 ? 65.979 -13.043 5.501 1.00 32.82 ? 412 GLU C C 1 ATOM 3908 O O . GLU C 1 88 ? 65.614 -12.547 6.562 1.00 33.17 ? 412 GLU C O 1 ATOM 3909 C CB . GLU C 1 88 ? 64.401 -11.917 3.944 1.00 33.87 ? 412 GLU C CB 1 ATOM 3910 C CG . GLU C 1 88 ? 64.187 -10.747 2.991 1.00 35.34 ? 412 GLU C CG 1 ATOM 3911 C CD . GLU C 1 88 ? 62.717 -10.502 2.693 1.00 36.88 ? 412 GLU C CD 1 ATOM 3912 O OE1 . GLU C 1 88 ? 61.905 -11.413 2.984 1.00 38.59 ? 412 GLU C OE1 1 ATOM 3913 O OE2 . GLU C 1 88 ? 62.380 -9.410 2.167 1.00 36.05 ? 412 GLU C OE2 1 ATOM 3914 N N . GLY C 1 89 ? 66.442 -14.290 5.396 1.00 32.10 ? 413 GLY C N 1 ATOM 3915 C CA . GLY C 1 89 ? 66.824 -15.081 6.572 1.00 31.36 ? 413 GLY C CA 1 ATOM 3916 C C . GLY C 1 89 ? 65.954 -16.267 6.965 1.00 30.74 ? 413 GLY C C 1 ATOM 3917 O O . GLY C 1 89 ? 65.980 -16.720 8.109 1.00 29.11 ? 413 GLY C O 1 ATOM 3918 N N . GLU C 1 90 ? 65.199 -16.797 6.012 1.00 30.63 ? 414 GLU C N 1 ATOM 3919 C CA . GLU C 1 90 ? 64.394 -17.985 6.255 1.00 30.03 ? 414 GLU C CA 1 ATOM 3920 C C . GLU C 1 90 ? 65.281 -19.146 6.728 1.00 29.57 ? 414 GLU C C 1 ATOM 3921 O O . GLU C 1 90 ? 66.456 -19.189 6.426 1.00 27.77 ? 414 GLU C O 1 ATOM 3922 C CB . GLU C 1 90 ? 63.649 -18.386 4.974 1.00 30.89 ? 414 GLU C CB 1 ATOM 3923 C CG . GLU C 1 90 ? 62.770 -19.633 5.089 1.00 30.39 ? 414 GLU C CG 1 ATOM 3924 C CD . GLU C 1 90 ? 61.573 -19.447 6.016 1.00 30.47 ? 414 GLU C CD 1 ATOM 3925 O OE1 . GLU C 1 90 ? 61.713 -19.516 7.260 1.00 31.06 ? 414 GLU C OE1 1 ATOM 3926 O OE2 . GLU C 1 90 ? 60.472 -19.227 5.485 1.00 29.40 ? 414 GLU C OE2 1 ATOM 3927 N N . THR C 1 91 ? 64.697 -20.053 7.506 1.00 28.31 ? 415 THR C N 1 ATOM 3928 C CA . THR C 1 91 ? 65.343 -21.275 7.927 1.00 27.58 ? 415 THR C CA 1 ATOM 3929 C C . THR C 1 91 ? 64.559 -22.434 7.314 1.00 28.41 ? 415 THR C C 1 ATOM 3930 O O . THR C 1 91 ? 63.336 -22.542 7.461 1.00 28.36 ? 415 THR C O 1 ATOM 3931 C CB . THR C 1 91 ? 65.287 -21.468 9.454 1.00 26.18 ? 415 THR C CB 1 ATOM 3932 O OG1 . THR C 1 91 ? 65.988 -20.422 10.135 1.00 26.07 ? 415 THR C OG1 1 ATOM 3933 C CG2 . THR C 1 91 ? 65.906 -22.786 9.832 1.00 26.88 ? 415 THR C CG2 1 ATOM 3934 N N . TYR C 1 92 ? 65.296 -23.296 6.634 1.00 29.16 ? 416 TYR C N 1 ATOM 3935 C CA . TYR C 1 92 ? 64.783 -24.480 5.974 1.00 30.48 ? 416 TYR C CA 1 ATOM 3936 C C . TYR C 1 92 ? 65.227 -25.713 6.729 1.00 32.20 ? 416 TYR C C 1 ATOM 3937 O O . TYR C 1 92 ? 66.326 -25.744 7.275 1.00 31.46 ? 416 TYR C O 1 ATOM 3938 C CB . TYR C 1 92 ? 65.335 -24.540 4.556 1.00 30.34 ? 416 TYR C CB 1 ATOM 3939 C CG . TYR C 1 92 ? 64.899 -23.367 3.712 1.00 31.57 ? 416 TYR C CG 1 ATOM 3940 C CD1 . TYR C 1 92 ? 65.528 -22.141 3.816 1.00 32.89 ? 416 TYR C CD1 1 ATOM 3941 C CD2 . TYR C 1 92 ? 63.840 -23.473 2.831 1.00 31.95 ? 416 TYR C CD2 1 ATOM 3942 C CE1 . TYR C 1 92 ? 65.127 -21.056 3.054 1.00 33.68 ? 416 TYR C CE1 1 ATOM 3943 C CE2 . TYR C 1 92 ? 63.438 -22.392 2.065 1.00 33.02 ? 416 TYR C CE2 1 ATOM 3944 C CZ . TYR C 1 92 ? 64.085 -21.187 2.181 1.00 33.17 ? 416 TYR C CZ 1 ATOM 3945 O OH . TYR C 1 92 ? 63.701 -20.104 1.423 1.00 35.48 ? 416 TYR C OH 1 ATOM 3946 N N . GLN C 1 93 ? 64.370 -26.726 6.766 1.00 36.34 ? 417 GLN C N 1 ATOM 3947 C CA . GLN C 1 93 ? 64.666 -27.943 7.528 1.00 38.57 ? 417 GLN C CA 1 ATOM 3948 C C . GLN C 1 93 ? 64.514 -29.196 6.694 1.00 37.36 ? 417 GLN C C 1 ATOM 3949 O O . GLN C 1 93 ? 63.576 -29.333 5.919 1.00 34.22 ? 417 GLN C O 1 ATOM 3950 C CB . GLN C 1 93 ? 63.786 -28.044 8.780 1.00 41.24 ? 417 GLN C CB 1 ATOM 3951 C CG . GLN C 1 93 ? 63.681 -26.721 9.523 1.00 44.62 ? 417 GLN C CG 1 ATOM 3952 C CD . GLN C 1 93 ? 63.479 -26.872 11.020 1.00 46.70 ? 417 GLN C CD 1 ATOM 3953 O OE1 . GLN C 1 93 ? 63.774 -25.947 11.790 1.00 48.47 ? 417 GLN C OE1 1 ATOM 3954 N NE2 . GLN C 1 93 ? 62.978 -28.033 11.444 1.00 48.09 ? 417 GLN C NE2 1 ATOM 3955 N N . CYS C 1 94 ? 65.473 -30.097 6.868 1.00 38.94 ? 418 CYS C N 1 ATOM 3956 C CA . CYS C 1 94 ? 65.470 -31.389 6.207 1.00 39.61 ? 418 CYS C CA 1 ATOM 3957 C C . CYS C 1 94 ? 65.380 -32.445 7.303 1.00 41.23 ? 418 CYS C C 1 ATOM 3958 O O . CYS C 1 94 ? 66.244 -32.502 8.180 1.00 40.88 ? 418 CYS C O 1 ATOM 3959 C CB . CYS C 1 94 ? 66.760 -31.592 5.415 1.00 39.94 ? 418 CYS C CB 1 ATOM 3960 S SG . CYS C 1 94 ? 66.868 -33.269 4.799 1.00 41.15 ? 418 CYS C SG 1 ATOM 3961 N N . ARG C 1 95 ? 64.334 -33.264 7.263 1.00 43.25 ? 419 ARG C N 1 ATOM 3962 C CA . ARG C 1 95 ? 64.154 -34.338 8.243 1.00 44.85 ? 419 ARG C CA 1 ATOM 3963 C C . ARG C 1 95 ? 64.406 -35.701 7.609 1.00 44.17 ? 419 ARG C C 1 ATOM 3964 O O . ARG C 1 95 ? 63.716 -36.071 6.661 1.00 42.52 ? 419 ARG C O 1 ATOM 3965 C CB . ARG C 1 95 ? 62.742 -34.295 8.841 1.00 46.60 ? 419 ARG C CB 1 ATOM 3966 C CG . ARG C 1 95 ? 62.442 -35.458 9.786 1.00 48.40 ? 419 ARG C CG 1 ATOM 3967 C CD . ARG C 1 95 ? 61.173 -35.246 10.609 1.00 50.03 ? 419 ARG C CD 1 ATOM 3968 N NE . ARG C 1 95 ? 60.978 -36.337 11.557 1.00 51.18 ? 419 ARG C NE 1 ATOM 3969 C CZ . ARG C 1 95 ? 59.974 -36.409 12.418 1.00 53.18 ? 419 ARG C CZ 1 ATOM 3970 N NH1 . ARG C 1 95 ? 59.054 -35.454 12.451 1.00 54.76 ? 419 ARG C NH1 1 ATOM 3971 N NH2 . ARG C 1 95 ? 59.887 -37.434 13.251 1.00 53.71 ? 419 ARG C NH2 1 ATOM 3972 N N . VAL C 1 96 ? 65.378 -36.437 8.149 1.00 44.98 ? 420 VAL C N 1 ATOM 3973 C CA . VAL C 1 96 ? 65.807 -37.720 7.583 1.00 46.72 ? 420 VAL C CA 1 ATOM 3974 C C . VAL C 1 96 ? 65.196 -38.936 8.290 1.00 49.29 ? 420 VAL C C 1 ATOM 3975 O O . VAL C 1 96 ? 65.424 -39.146 9.481 1.00 49.57 ? 420 VAL C O 1 ATOM 3976 C CB . VAL C 1 96 ? 67.347 -37.844 7.607 1.00 45.67 ? 420 VAL C CB 1 ATOM 3977 C CG1 . VAL C 1 96 ? 67.791 -39.192 7.085 1.00 43.69 ? 420 VAL C CG1 1 ATOM 3978 C CG2 . VAL C 1 96 ? 67.972 -36.725 6.771 1.00 46.16 ? 420 VAL C CG2 1 ATOM 3979 N N . THR C 1 97 ? 64.433 -39.737 7.547 1.00 52.54 ? 421 THR C N 1 ATOM 3980 C CA . THR C 1 97 ? 63.795 -40.935 8.091 1.00 55.38 ? 421 THR C CA 1 ATOM 3981 C C . THR C 1 97 ? 64.256 -42.225 7.411 1.00 58.51 ? 421 THR C C 1 ATOM 3982 O O . THR C 1 97 ? 63.769 -42.568 6.333 1.00 58.95 ? 421 THR C O 1 ATOM 3983 C CB . THR C 1 97 ? 62.258 -40.872 7.960 1.00 54.99 ? 421 THR C CB 1 ATOM 3984 O OG1 . THR C 1 97 ? 61.734 -39.915 8.888 1.00 54.47 ? 421 THR C OG1 1 ATOM 3985 C CG2 . THR C 1 97 ? 61.640 -42.237 8.250 1.00 55.42 ? 421 THR C CG2 1 ATOM 3986 N N . HIS C 1 98 ? 65.182 -42.936 8.058 1.00 62.54 ? 422 HIS C N 1 ATOM 3987 C CA . HIS C 1 98 ? 65.565 -44.312 7.686 1.00 65.20 ? 422 HIS C CA 1 ATOM 3988 C C . HIS C 1 98 ? 64.600 -45.304 8.362 1.00 65.99 ? 422 HIS C C 1 ATOM 3989 O O . HIS C 1 98 ? 64.218 -45.125 9.522 1.00 66.10 ? 422 HIS C O 1 ATOM 3990 C CB . HIS C 1 98 ? 67.025 -44.591 8.114 1.00 66.40 ? 422 HIS C CB 1 ATOM 3991 C CG . HIS C 1 98 ? 67.723 -45.679 7.340 1.00 67.59 ? 422 HIS C CG 1 ATOM 3992 N ND1 . HIS C 1 98 ? 67.656 -47.012 7.692 1.00 68.00 ? 422 HIS C ND1 1 ATOM 3993 C CD2 . HIS C 1 98 ? 68.536 -45.624 6.255 1.00 68.10 ? 422 HIS C CD2 1 ATOM 3994 C CE1 . HIS C 1 98 ? 68.376 -47.731 6.848 1.00 67.97 ? 422 HIS C CE1 1 ATOM 3995 N NE2 . HIS C 1 98 ? 68.921 -46.912 5.966 1.00 68.10 ? 422 HIS C NE2 1 ATOM 3996 N N . PRO C 1 99 ? 64.191 -46.351 7.632 1.00 67.04 ? 423 PRO C N 1 ATOM 3997 C CA . PRO C 1 99 ? 63.425 -47.429 8.257 1.00 67.81 ? 423 PRO C CA 1 ATOM 3998 C C . PRO C 1 99 ? 64.093 -47.950 9.532 1.00 68.46 ? 423 PRO C C 1 ATOM 3999 O O . PRO C 1 99 ? 63.407 -48.183 10.527 1.00 67.62 ? 423 PRO C O 1 ATOM 4000 C CB . PRO C 1 99 ? 63.401 -48.512 7.177 1.00 67.65 ? 423 PRO C CB 1 ATOM 4001 C CG . PRO C 1 99 ? 63.552 -47.755 5.885 1.00 67.51 ? 423 PRO C CG 1 ATOM 4002 C CD . PRO C 1 99 ? 64.425 -46.581 6.195 1.00 67.27 ? 423 PRO C CD 1 ATOM 4003 N N . HIS C 1 100 ? 65.416 -48.108 9.488 1.00 69.84 ? 424 HIS C N 1 ATOM 4004 C CA . HIS C 1 100 ? 66.202 -48.621 10.613 1.00 71.22 ? 424 HIS C CA 1 ATOM 4005 C C . HIS C 1 100 ? 66.947 -47.505 11.362 1.00 71.88 ? 424 HIS C C 1 ATOM 4006 O O . HIS C 1 100 ? 68.137 -47.277 11.129 1.00 72.38 ? 424 HIS C O 1 ATOM 4007 C CB . HIS C 1 100 ? 67.219 -49.670 10.125 1.00 71.66 ? 424 HIS C CB 1 ATOM 4008 C CG . HIS C 1 100 ? 66.618 -50.780 9.314 1.00 71.86 ? 424 HIS C CG 1 ATOM 4009 N ND1 . HIS C 1 100 ? 67.048 -51.089 8.041 1.00 72.00 ? 424 HIS C ND1 1 ATOM 4010 C CD2 . HIS C 1 100 ? 65.621 -51.652 9.596 1.00 71.92 ? 424 HIS C CD2 1 ATOM 4011 C CE1 . HIS C 1 100 ? 66.342 -52.103 7.573 1.00 72.03 ? 424 HIS C CE1 1 ATOM 4012 N NE2 . HIS C 1 100 ? 65.468 -52.462 8.497 1.00 72.14 ? 424 HIS C NE2 1 ATOM 4013 N N . LEU C 1 101 ? 66.245 -46.812 12.257 1.00 72.29 ? 425 LEU C N 1 ATOM 4014 C CA . LEU C 1 101 ? 66.876 -45.870 13.186 1.00 72.14 ? 425 LEU C CA 1 ATOM 4015 C C . LEU C 1 101 ? 65.883 -45.401 14.248 1.00 71.77 ? 425 LEU C C 1 ATOM 4016 O O . LEU C 1 101 ? 64.707 -45.192 13.946 1.00 71.54 ? 425 LEU C O 1 ATOM 4017 C CB . LEU C 1 101 ? 67.440 -44.655 12.445 1.00 72.46 ? 425 LEU C CB 1 ATOM 4018 C CG . LEU C 1 101 ? 66.467 -43.818 11.605 1.00 72.60 ? 425 LEU C CG 1 ATOM 4019 C CD1 . LEU C 1 101 ? 65.282 -43.279 12.404 1.00 72.82 ? 425 LEU C CD1 1 ATOM 4020 C CD2 . LEU C 1 101 ? 67.228 -42.679 10.961 1.00 72.37 ? 425 LEU C CD2 1 ATOM 4021 N N . PRO C 1 102 ? 66.357 -45.216 15.494 1.00 71.67 ? 426 PRO C N 1 ATOM 4022 C CA . PRO C 1 102 ? 65.440 -44.902 16.594 1.00 70.89 ? 426 PRO C CA 1 ATOM 4023 C C . PRO C 1 102 ? 64.848 -43.500 16.472 1.00 69.53 ? 426 PRO C C 1 ATOM 4024 O O . PRO C 1 102 ? 63.627 -43.346 16.499 1.00 69.33 ? 426 PRO C O 1 ATOM 4025 C CB . PRO C 1 102 ? 66.317 -45.008 17.855 1.00 71.26 ? 426 PRO C CB 1 ATOM 4026 C CG . PRO C 1 102 ? 67.676 -45.470 17.400 1.00 71.63 ? 426 PRO C CG 1 ATOM 4027 C CD . PRO C 1 102 ? 67.765 -45.181 15.926 1.00 71.85 ? 426 PRO C CD 1 ATOM 4028 N N . ARG C 1 103 ? 65.708 -42.493 16.336 1.00 67.75 ? 427 ARG C N 1 ATOM 4029 C CA . ARG C 1 103 ? 65.257 -41.109 16.234 1.00 66.19 ? 427 ARG C CA 1 ATOM 4030 C C . ARG C 1 103 ? 65.554 -40.570 14.843 1.00 64.04 ? 427 ARG C C 1 ATOM 4031 O O . ARG C 1 103 ? 66.640 -40.781 14.307 1.00 64.33 ? 427 ARG C O 1 ATOM 4032 C CB . ARG C 1 103 ? 65.921 -40.235 17.307 1.00 66.97 ? 427 ARG C CB 1 ATOM 4033 C CG . ARG C 1 103 ? 65.349 -40.426 18.724 1.00 67.66 ? 427 ARG C CG 1 ATOM 4034 C CD . ARG C 1 103 ? 66.208 -39.772 19.819 1.00 67.91 ? 427 ARG C CD 1 ATOM 4035 N NE . ARG C 1 103 ? 67.237 -40.669 20.356 1.00 68.02 ? 427 ARG C NE 1 ATOM 4036 C CZ . ARG C 1 103 ? 68.508 -40.707 19.955 1.00 67.99 ? 427 ARG C CZ 1 ATOM 4037 N NH1 . ARG C 1 103 ? 68.948 -39.897 18.998 1.00 67.94 ? 427 ARG C NH1 1 ATOM 4038 N NH2 . ARG C 1 103 ? 69.352 -41.567 20.512 1.00 67.75 ? 427 ARG C NH2 1 ATOM 4039 N N . ALA C 1 104 ? 64.574 -39.885 14.262 1.00 61.13 ? 428 ALA C N 1 ATOM 4040 C CA . ALA C 1 104 ? 64.728 -39.256 12.955 1.00 58.46 ? 428 ALA C CA 1 ATOM 4041 C C . ALA C 1 104 ? 65.760 -38.138 13.040 1.00 56.14 ? 428 ALA C C 1 ATOM 4042 O O . ALA C 1 104 ? 65.790 -37.414 14.031 1.00 55.97 ? 428 ALA C O 1 ATOM 4043 C CB . ALA C 1 104 ? 63.393 -38.696 12.493 1.00 57.99 ? 428 ALA C CB 1 ATOM 4044 N N . LEU C 1 105 ? 66.595 -38.003 12.008 1.00 53.83 ? 429 LEU C N 1 ATOM 4045 C CA . LEU C 1 105 ? 67.653 -36.983 11.967 1.00 51.98 ? 429 LEU C CA 1 ATOM 4046 C C . LEU C 1 105 ? 67.144 -35.663 11.384 1.00 50.63 ? 429 LEU C C 1 ATOM 4047 O O . LEU C 1 105 ? 66.594 -35.633 10.284 1.00 49.35 ? 429 LEU C O 1 ATOM 4048 C CB . LEU C 1 105 ? 68.855 -37.466 11.140 1.00 51.43 ? 429 LEU C CB 1 ATOM 4049 C CG . LEU C 1 105 ? 69.829 -38.483 11.751 1.00 50.75 ? 429 LEU C CG 1 ATOM 4050 C CD1 . LEU C 1 105 ? 70.742 -39.028 10.658 1.00 49.90 ? 429 LEU C CD1 1 ATOM 4051 C CD2 . LEU C 1 105 ? 70.641 -37.872 12.901 1.00 50.00 ? 429 LEU C CD2 1 ATOM 4052 N N . MET C 1 106 ? 67.336 -34.576 12.122 1.00 49.81 ? 430 MET C N 1 ATOM 4053 C CA . MET C 1 106 ? 66.852 -33.269 11.693 1.00 49.58 ? 430 MET C CA 1 ATOM 4054 C C . MET C 1 106 ? 68.032 -32.347 11.369 1.00 46.81 ? 430 MET C C 1 ATOM 4055 O O . MET C 1 106 ? 69.004 -32.296 12.113 1.00 44.75 ? 430 MET C O 1 ATOM 4056 C CB . MET C 1 106 ? 65.921 -32.676 12.759 1.00 52.09 ? 430 MET C CB 1 ATOM 4057 C CG . MET C 1 106 ? 66.569 -32.299 14.110 1.00 54.59 ? 430 MET C CG 1 ATOM 4058 S SD . MET C 1 106 ? 67.030 -33.630 15.275 1.00 58.38 ? 430 MET C SD 1 ATOM 4059 C CE . MET C 1 106 ? 66.830 -32.829 16.882 1.00 56.40 ? 430 MET C CE 1 ATOM 4060 N N . ARG C 1 107 ? 67.964 -31.650 10.234 1.00 44.68 ? 431 ARG C N 1 ATOM 4061 C CA . ARG C 1 107 ? 69.015 -30.709 9.830 1.00 42.41 ? 431 ARG C CA 1 ATOM 4062 C C . ARG C 1 107 ? 68.389 -29.416 9.359 1.00 38.86 ? 431 ARG C C 1 ATOM 4063 O O . ARG C 1 107 ? 67.332 -29.410 8.718 1.00 35.81 ? 431 ARG C O 1 ATOM 4064 C CB . ARG C 1 107 ? 69.875 -31.243 8.677 1.00 44.65 ? 431 ARG C CB 1 ATOM 4065 C CG . ARG C 1 107 ? 70.614 -32.539 8.957 1.00 47.06 ? 431 ARG C CG 1 ATOM 4066 C CD . ARG C 1 107 ? 71.840 -32.348 9.827 1.00 49.10 ? 431 ARG C CD 1 ATOM 4067 N NE . ARG C 1 107 ? 72.242 -33.635 10.384 1.00 52.31 ? 431 ARG C NE 1 ATOM 4068 C CZ . ARG C 1 107 ? 73.049 -33.788 11.428 1.00 54.35 ? 431 ARG C CZ 1 ATOM 4069 N NH1 . ARG C 1 107 ? 73.559 -32.717 12.026 1.00 56.09 ? 431 ARG C NH1 1 ATOM 4070 N NH2 . ARG C 1 107 ? 73.349 -35.009 11.866 1.00 54.42 ? 431 ARG C NH2 1 ATOM 4071 N N . SER C 1 108 ? 69.054 -28.312 9.666 1.00 35.70 ? 432 SER C N 1 ATOM 4072 C CA . SER C 1 108 ? 68.539 -27.032 9.240 1.00 34.45 ? 432 SER C CA 1 ATOM 4073 C C . SER C 1 108 ? 69.640 -26.106 8.746 1.00 32.74 ? 432 SER C C 1 ATOM 4074 O O . SER C 1 108 ? 70.780 -26.146 9.202 1.00 32.11 ? 432 SER C O 1 ATOM 4075 C CB . SER C 1 108 ? 67.782 -26.368 10.376 1.00 34.32 ? 432 SER C CB 1 ATOM 4076 O OG . SER C 1 108 ? 68.714 -25.988 11.356 1.00 37.10 ? 432 SER C OG 1 ATOM 4077 N N . THR C 1 109 ? 69.271 -25.265 7.792 1.00 30.94 ? 433 THR C N 1 ATOM 4078 C CA . THR C 1 109 ? 70.184 -24.262 7.282 1.00 28.94 ? 433 THR C CA 1 ATOM 4079 C C . THR C 1 109 ? 69.510 -22.899 7.169 1.00 28.96 ? 433 THR C C 1 ATOM 4080 O O . THR C 1 109 ? 68.274 -22.788 7.099 1.00 28.08 ? 433 THR C O 1 ATOM 4081 C CB . THR C 1 109 ? 70.724 -24.669 5.928 1.00 28.57 ? 433 THR C CB 1 ATOM 4082 O OG1 . THR C 1 109 ? 71.762 -23.765 5.556 1.00 28.23 ? 433 THR C OG1 1 ATOM 4083 C CG2 . THR C 1 109 ? 69.625 -24.689 4.874 1.00 29.26 ? 433 THR C CG2 1 ATOM 4084 N N . THR C 1 110 ? 70.345 -21.862 7.190 1.00 26.50 ? 434 THR C N 1 ATOM 4085 C CA . THR C 1 110 ? 69.900 -20.479 7.116 1.00 24.74 ? 434 THR C CA 1 ATOM 4086 C C . THR C 1 110 ? 71.085 -19.646 6.683 1.00 26.71 ? 434 THR C C 1 ATOM 4087 O O . THR C 1 110 ? 72.220 -20.065 6.837 1.00 26.62 ? 434 THR C O 1 ATOM 4088 C CB . THR C 1 110 ? 69.400 -19.951 8.471 1.00 23.11 ? 434 THR C CB 1 ATOM 4089 O OG1 . THR C 1 110 ? 68.707 -18.713 8.272 1.00 22.51 ? 434 THR C OG1 1 ATOM 4090 C CG2 . THR C 1 110 ? 70.552 -19.756 9.483 1.00 20.00 ? 434 THR C CG2 1 ATOM 4091 N N . LYS C 1 111 ? 70.816 -18.471 6.138 1.00 29.55 ? 435 LYS C N 1 ATOM 4092 C CA . LYS C 1 111 ? 71.852 -17.533 5.765 1.00 32.25 ? 435 LYS C CA 1 ATOM 4093 C C . LYS C 1 111 ? 72.706 -17.168 6.985 1.00 33.82 ? 435 LYS C C 1 ATOM 4094 O O . LYS C 1 111 ? 72.169 -16.798 8.028 1.00 33.26 ? 435 LYS C O 1 ATOM 4095 C CB . LYS C 1 111 ? 71.156 -16.309 5.189 1.00 33.79 ? 435 LYS C CB 1 ATOM 4096 C CG . LYS C 1 111 ? 72.058 -15.190 4.735 1.00 35.90 ? 435 LYS C CG 1 ATOM 4097 C CD . LYS C 1 111 ? 71.210 -13.975 4.352 1.00 36.91 ? 435 LYS C CD 1 ATOM 4098 C CE . LYS C 1 111 ? 71.934 -12.654 4.669 1.00 38.34 ? 435 LYS C CE 1 ATOM 4099 N NZ . LYS C 1 111 ? 71.068 -11.438 4.613 1.00 37.75 ? 435 LYS C NZ 1 ATOM 4100 N N . THR C 1 112 ? 74.031 -17.272 6.870 1.00 34.54 ? 436 THR C N 1 ATOM 4101 C CA . THR C 1 112 ? 74.905 -16.867 7.965 1.00 35.53 ? 436 THR C CA 1 ATOM 4102 C C . THR C 1 112 ? 74.733 -15.381 8.223 1.00 36.72 ? 436 THR C C 1 ATOM 4103 O O . THR C 1 112 ? 74.763 -14.569 7.300 1.00 34.61 ? 436 THR C O 1 ATOM 4104 C CB . THR C 1 112 ? 76.390 -17.161 7.691 1.00 36.29 ? 436 THR C CB 1 ATOM 4105 O OG1 . THR C 1 112 ? 76.524 -18.485 7.187 1.00 36.91 ? 436 THR C OG1 1 ATOM 4106 C CG2 . THR C 1 112 ? 77.216 -17.076 8.972 1.00 36.52 ? 436 THR C CG2 1 ATOM 4107 N N . SER C 1 113 ? 74.553 -15.014 9.484 1.00 39.68 ? 437 SER C N 1 ATOM 4108 C CA . SER C 1 113 ? 74.173 -13.641 9.787 1.00 42.55 ? 437 SER C CA 1 ATOM 4109 C C . SER C 1 113 ? 75.070 -13.060 10.839 1.00 41.06 ? 437 SER C C 1 ATOM 4110 O O . SER C 1 113 ? 74.761 -13.191 12.030 1.00 43.66 ? 437 SER C O 1 ATOM 4111 C CB . SER C 1 113 ? 72.726 -13.535 10.304 1.00 45.08 ? 437 SER C CB 1 ATOM 4112 O OG . SER C 1 113 ? 71.836 -13.102 9.271 1.00 47.72 ? 437 SER C OG 1 ATOM 4113 N N . GLY C 1 114 ? 76.151 -12.433 10.390 1.00 37.26 ? 438 GLY C N 1 ATOM 4114 C CA . GLY C 1 114 ? 76.925 -11.497 11.198 1.00 35.37 ? 438 GLY C CA 1 ATOM 4115 C C . GLY C 1 114 ? 77.376 -10.377 10.278 1.00 34.40 ? 438 GLY C C 1 ATOM 4116 O O . GLY C 1 114 ? 76.633 -9.982 9.386 1.00 33.69 ? 438 GLY C O 1 ATOM 4117 N N . PRO C 1 115 ? 78.610 -9.889 10.455 1.00 33.06 ? 439 PRO C N 1 ATOM 4118 C CA . PRO C 1 115 ? 79.151 -8.832 9.609 1.00 33.36 ? 439 PRO C CA 1 ATOM 4119 C C . PRO C 1 115 ? 79.508 -9.299 8.194 1.00 32.86 ? 439 PRO C C 1 ATOM 4120 O O . PRO C 1 115 ? 79.877 -10.461 8.002 1.00 32.14 ? 439 PRO C O 1 ATOM 4121 C CB . PRO C 1 115 ? 80.437 -8.414 10.343 1.00 33.32 ? 439 PRO C CB 1 ATOM 4122 C CG . PRO C 1 115 ? 80.387 -9.059 11.678 1.00 33.77 ? 439 PRO C CG 1 ATOM 4123 C CD . PRO C 1 115 ? 79.548 -10.274 11.520 1.00 33.66 ? 439 PRO C CD 1 ATOM 4124 N N . ARG C 1 116 ? 79.406 -8.384 7.232 1.00 32.12 ? 440 ARG C N 1 ATOM 4125 C CA . ARG C 1 116 ? 79.803 -8.627 5.837 1.00 31.69 ? 440 ARG C CA 1 ATOM 4126 C C . ARG C 1 116 ? 81.111 -7.918 5.434 1.00 28.37 ? 440 ARG C C 1 ATOM 4127 O O . ARG C 1 116 ? 81.426 -6.827 5.913 1.00 27.33 ? 440 ARG C O 1 ATOM 4128 C CB . ARG C 1 116 ? 78.717 -8.140 4.871 1.00 32.19 ? 440 ARG C CB 1 ATOM 4129 C CG . ARG C 1 116 ? 77.290 -8.373 5.335 1.00 34.78 ? 440 ARG C CG 1 ATOM 4130 C CD . ARG C 1 116 ? 76.705 -9.706 4.939 1.00 34.64 ? 440 ARG C CD 1 ATOM 4131 N NE . ARG C 1 116 ? 76.898 -10.649 6.029 1.00 36.08 ? 440 ARG C NE 1 ATOM 4132 C CZ . ARG C 1 116 ? 76.178 -11.754 6.204 1.00 36.05 ? 440 ARG C CZ 1 ATOM 4133 N NH1 . ARG C 1 116 ? 75.220 -12.060 5.354 1.00 35.21 ? 440 ARG C NH1 1 ATOM 4134 N NH2 . ARG C 1 116 ? 76.419 -12.549 7.234 1.00 35.39 ? 440 ARG C NH2 1 ATOM 4135 N N . ALA C 1 117 ? 81.874 -8.526 4.535 1.00 24.81 ? 441 ALA C N 1 ATOM 4136 C CA . ALA C 1 117 ? 82.999 -7.808 3.943 1.00 24.72 ? 441 ALA C CA 1 ATOM 4137 C C . ALA C 1 117 ? 83.368 -8.373 2.579 1.00 23.36 ? 441 ALA C C 1 ATOM 4138 O O . ALA C 1 117 ? 83.258 -9.561 2.325 1.00 23.02 ? 441 ALA C O 1 ATOM 4139 C CB . ALA C 1 117 ? 84.217 -7.816 4.892 1.00 23.25 ? 441 ALA C CB 1 ATOM 4140 N N . ALA C 1 118 ? 83.816 -7.507 1.686 1.00 25.59 ? 442 ALA C N 1 ATOM 4141 C CA . ALA C 1 118 ? 84.055 -7.917 0.301 1.00 25.96 ? 442 ALA C CA 1 ATOM 4142 C C . ALA C 1 118 ? 85.379 -8.662 0.197 1.00 24.87 ? 442 ALA C C 1 ATOM 4143 O O . ALA C 1 118 ? 86.285 -8.376 0.974 1.00 26.92 ? 442 ALA C O 1 ATOM 4144 C CB . ALA C 1 118 ? 84.041 -6.709 -0.619 1.00 25.75 ? 442 ALA C CB 1 ATOM 4145 N N . PRO C 1 119 ? 85.490 -9.603 -0.759 1.00 22.71 ? 443 PRO C N 1 ATOM 4146 C CA . PRO C 1 119 ? 86.710 -10.355 -0.997 1.00 24.18 ? 443 PRO C CA 1 ATOM 4147 C C . PRO C 1 119 ? 87.778 -9.590 -1.755 1.00 23.81 ? 443 PRO C C 1 ATOM 4148 O O . PRO C 1 119 ? 87.455 -8.868 -2.685 1.00 25.61 ? 443 PRO C O 1 ATOM 4149 C CB . PRO C 1 119 ? 86.233 -11.533 -1.842 1.00 23.95 ? 443 PRO C CB 1 ATOM 4150 C CG . PRO C 1 119 ? 85.011 -11.062 -2.519 1.00 23.29 ? 443 PRO C CG 1 ATOM 4151 C CD . PRO C 1 119 ? 84.471 -9.890 -1.779 1.00 23.27 ? 443 PRO C CD 1 ATOM 4152 N N . GLU C 1 120 ? 89.045 -9.751 -1.377 1.00 24.47 ? 444 GLU C N 1 ATOM 4153 C CA . GLU C 1 120 ? 90.154 -9.270 -2.222 1.00 22.74 ? 444 GLU C CA 1 ATOM 4154 C C . GLU C 1 120 ? 90.567 -10.459 -3.079 1.00 22.52 ? 444 GLU C C 1 ATOM 4155 O O . GLU C 1 120 ? 90.653 -11.583 -2.578 1.00 24.47 ? 444 GLU C O 1 ATOM 4156 C CB . GLU C 1 120 ? 91.307 -8.777 -1.346 1.00 24.17 ? 444 GLU C CB 1 ATOM 4157 C CG . GLU C 1 120 ? 90.817 -7.887 -0.167 1.00 24.00 ? 444 GLU C CG 1 ATOM 4158 C CD . GLU C 1 120 ? 91.848 -7.649 0.925 1.00 24.26 ? 444 GLU C CD 1 ATOM 4159 O OE1 . GLU C 1 120 ? 92.984 -8.175 0.828 1.00 24.04 ? 444 GLU C OE1 1 ATOM 4160 O OE2 . GLU C 1 120 ? 91.500 -6.919 1.891 1.00 27.30 ? 444 GLU C OE2 1 ATOM 4161 N N . VAL C 1 121 ? 90.781 -10.217 -4.371 1.00 20.99 ? 445 VAL C N 1 ATOM 4162 C CA . VAL C 1 121 ? 91.200 -11.235 -5.313 1.00 19.51 ? 445 VAL C CA 1 ATOM 4163 C C . VAL C 1 121 ? 92.563 -10.927 -5.921 1.00 20.77 ? 445 VAL C C 1 ATOM 4164 O O . VAL C 1 121 ? 92.813 -9.811 -6.397 1.00 20.66 ? 445 VAL C O 1 ATOM 4165 C CB . VAL C 1 121 ? 90.200 -11.330 -6.467 1.00 19.45 ? 445 VAL C CB 1 ATOM 4166 C CG1 . VAL C 1 121 ? 90.652 -12.399 -7.443 1.00 13.91 ? 445 VAL C CG1 1 ATOM 4167 C CG2 . VAL C 1 121 ? 88.784 -11.585 -5.936 1.00 17.29 ? 445 VAL C CG2 1 ATOM 4168 N N . TYR C 1 122 ? 93.455 -11.910 -5.929 1.00 20.32 ? 446 TYR C N 1 ATOM 4169 C CA . TYR C 1 122 ? 94.740 -11.721 -6.595 1.00 21.61 ? 446 TYR C CA 1 ATOM 4170 C C . TYR C 1 122 ? 95.074 -12.949 -7.404 1.00 22.83 ? 446 TYR C C 1 ATOM 4171 O O . TYR C 1 122 ? 94.973 -14.060 -6.857 1.00 26.97 ? 446 TYR C O 1 ATOM 4172 C CB . TYR C 1 122 ? 95.852 -11.564 -5.578 1.00 22.92 ? 446 TYR C CB 1 ATOM 4173 C CG . TYR C 1 122 ? 95.552 -10.579 -4.470 1.00 25.20 ? 446 TYR C CG 1 ATOM 4174 C CD1 . TYR C 1 122 ? 95.019 -11.003 -3.248 1.00 25.26 ? 446 TYR C CD1 1 ATOM 4175 C CD2 . TYR C 1 122 ? 95.802 -9.226 -4.645 1.00 24.37 ? 446 TYR C CD2 1 ATOM 4176 C CE1 . TYR C 1 122 ? 94.759 -10.094 -2.236 1.00 25.69 ? 446 TYR C CE1 1 ATOM 4177 C CE2 . TYR C 1 122 ? 95.538 -8.332 -3.642 1.00 25.02 ? 446 TYR C CE2 1 ATOM 4178 C CZ . TYR C 1 122 ? 95.022 -8.772 -2.446 1.00 24.56 ? 446 TYR C CZ 1 ATOM 4179 O OH . TYR C 1 122 ? 94.759 -7.858 -1.468 1.00 27.37 ? 446 TYR C OH 1 ATOM 4180 N N . ALA C 1 123 ? 95.483 -12.766 -8.659 1.00 18.42 ? 447 ALA C N 1 ATOM 4181 C CA . ALA C 1 123 ? 95.773 -13.893 -9.524 1.00 19.42 ? 447 ALA C CA 1 ATOM 4182 C C . ALA C 1 123 ? 97.243 -13.909 -9.893 1.00 19.49 ? 447 ALA C C 1 ATOM 4183 O O . ALA C 1 123 ? 97.847 -12.865 -10.162 1.00 21.30 ? 447 ALA C O 1 ATOM 4184 C CB . ALA C 1 123 ? 94.909 -13.833 -10.791 1.00 18.39 ? 447 ALA C CB 1 ATOM 4185 N N . PHE C 1 124 ? 97.822 -15.098 -9.929 1.00 18.38 ? 448 PHE C N 1 ATOM 4186 C CA . PHE C 1 124 ? 99.260 -15.226 -10.162 1.00 20.00 ? 448 PHE C CA 1 ATOM 4187 C C . PHE C 1 124 ? 99.487 -16.329 -11.147 1.00 18.74 ? 448 PHE C C 1 ATOM 4188 O O . PHE C 1 124 ? 98.670 -17.242 -11.240 1.00 18.35 ? 448 PHE C O 1 ATOM 4189 C CB . PHE C 1 124 ? 100.018 -15.583 -8.883 1.00 24.21 ? 448 PHE C CB 1 ATOM 4190 C CG . PHE C 1 124 ? 99.847 -14.578 -7.770 1.00 26.26 ? 448 PHE C CG 1 ATOM 4191 C CD1 . PHE C 1 124 ? 98.975 -14.825 -6.731 1.00 26.93 ? 448 PHE C CD1 1 ATOM 4192 C CD2 . PHE C 1 124 ? 100.550 -13.385 -7.777 1.00 26.20 ? 448 PHE C CD2 1 ATOM 4193 C CE1 . PHE C 1 124 ? 98.801 -13.894 -5.710 1.00 27.29 ? 448 PHE C CE1 1 ATOM 4194 C CE2 . PHE C 1 124 ? 100.373 -12.462 -6.761 1.00 26.59 ? 448 PHE C CE2 1 ATOM 4195 C CZ . PHE C 1 124 ? 99.501 -12.719 -5.728 1.00 26.15 ? 448 PHE C CZ 1 ATOM 4196 N N . ALA C 1 125 ? 100.601 -16.230 -11.859 1.00 17.84 ? 449 ALA C N 1 ATOM 4197 C CA . ALA C 1 125 ? 101.014 -17.207 -12.850 1.00 17.83 ? 449 ALA C CA 1 ATOM 4198 C C . ALA C 1 125 ? 102.415 -17.672 -12.476 1.00 18.53 ? 449 ALA C C 1 ATOM 4199 O O . ALA C 1 125 ? 103.298 -16.859 -12.271 1.00 17.66 ? 449 ALA C O 1 ATOM 4200 C CB . ALA C 1 125 ? 101.048 -16.580 -14.225 1.00 14.55 ? 449 ALA C CB 1 ATOM 4201 N N . THR C 1 126 ? 102.628 -18.980 -12.426 1.00 20.11 ? 450 THR C N 1 ATOM 4202 C CA . THR C 1 126 ? 103.938 -19.510 -12.134 1.00 21.99 ? 450 THR C CA 1 ATOM 4203 C C . THR C 1 126 ? 104.849 -19.278 -13.332 1.00 23.84 ? 450 THR C C 1 ATOM 4204 O O . THR C 1 126 ? 104.385 -19.257 -14.465 1.00 21.57 ? 450 THR C O 1 ATOM 4205 C CB . THR C 1 126 ? 103.858 -20.989 -11.766 1.00 21.82 ? 450 THR C CB 1 ATOM 4206 O OG1 . THR C 1 126 ? 103.408 -21.744 -12.900 1.00 23.01 ? 450 THR C OG1 1 ATOM 4207 C CG2 . THR C 1 126 ? 102.890 -21.153 -10.614 1.00 20.39 ? 450 THR C CG2 1 ATOM 4208 N N . PRO C 1 127 ? 106.149 -19.059 -13.079 1.00 29.10 ? 451 PRO C N 1 ATOM 4209 C CA . PRO C 1 127 ? 107.147 -19.008 -14.158 1.00 31.69 ? 451 PRO C CA 1 ATOM 4210 C C . PRO C 1 127 ? 107.350 -20.386 -14.772 1.00 34.78 ? 451 PRO C C 1 ATOM 4211 O O . PRO C 1 127 ? 106.903 -21.395 -14.222 1.00 34.42 ? 451 PRO C O 1 ATOM 4212 C CB . PRO C 1 127 ? 108.432 -18.552 -13.463 1.00 31.44 ? 451 PRO C CB 1 ATOM 4213 C CG . PRO C 1 127 ? 108.038 -18.077 -12.111 1.00 31.74 ? 451 PRO C CG 1 ATOM 4214 C CD . PRO C 1 127 ? 106.723 -18.727 -11.767 1.00 30.33 ? 451 PRO C CD 1 ATOM 4215 N N . GLU C 1 128 ? 108.002 -20.424 -15.921 1.00 40.24 ? 452 GLU C N 1 ATOM 4216 C CA . GLU C 1 128 ? 108.183 -21.683 -16.627 1.00 45.18 ? 452 GLU C CA 1 ATOM 4217 C C . GLU C 1 128 ? 109.103 -22.524 -15.768 1.00 48.18 ? 452 GLU C C 1 ATOM 4218 O O . GLU C 1 128 ? 110.229 -22.118 -15.480 1.00 49.85 ? 452 GLU C O 1 ATOM 4219 C CB . GLU C 1 128 ? 108.803 -21.425 -17.996 1.00 46.43 ? 452 GLU C CB 1 ATOM 4220 C CG . GLU C 1 128 ? 109.064 -22.657 -18.841 1.00 47.97 ? 452 GLU C CG 1 ATOM 4221 C CD . GLU C 1 128 ? 109.676 -22.298 -20.195 1.00 49.58 ? 452 GLU C CD 1 ATOM 4222 O OE1 . GLU C 1 128 ? 109.274 -21.281 -20.809 1.00 49.64 ? 452 GLU C OE1 1 ATOM 4223 O OE2 . GLU C 1 128 ? 110.575 -23.038 -20.647 1.00 52.06 ? 452 GLU C OE2 1 ATOM 4224 N N . TRP C 1 129 ? 108.625 -23.682 -15.331 1.00 50.69 ? 453 TRP C N 1 ATOM 4225 C CA . TRP C 1 129 ? 109.468 -24.556 -14.537 1.00 51.93 ? 453 TRP C CA 1 ATOM 4226 C C . TRP C 1 129 ? 110.298 -25.409 -15.482 1.00 52.83 ? 453 TRP C C 1 ATOM 4227 O O . TRP C 1 129 ? 109.827 -25.811 -16.552 1.00 52.62 ? 453 TRP C O 1 ATOM 4228 C CB . TRP C 1 129 ? 108.639 -25.426 -13.591 1.00 53.15 ? 453 TRP C CB 1 ATOM 4229 C CG . TRP C 1 129 ? 109.469 -26.210 -12.597 1.00 54.16 ? 453 TRP C CG 1 ATOM 4230 C CD1 . TRP C 1 129 ? 109.813 -27.531 -12.682 1.00 54.30 ? 453 TRP C CD1 1 ATOM 4231 C CD2 . TRP C 1 129 ? 110.057 -25.721 -11.376 1.00 54.84 ? 453 TRP C CD2 1 ATOM 4232 N NE1 . TRP C 1 129 ? 110.576 -27.893 -11.596 1.00 54.70 ? 453 TRP C NE1 1 ATOM 4233 C CE2 . TRP C 1 129 ? 110.743 -26.803 -10.780 1.00 54.79 ? 453 TRP C CE2 1 ATOM 4234 C CE3 . TRP C 1 129 ? 110.077 -24.474 -10.734 1.00 54.87 ? 453 TRP C CE3 1 ATOM 4235 C CZ2 . TRP C 1 129 ? 111.438 -26.678 -9.569 1.00 54.54 ? 453 TRP C CZ2 1 ATOM 4236 C CZ3 . TRP C 1 129 ? 110.772 -24.354 -9.528 1.00 54.79 ? 453 TRP C CZ3 1 ATOM 4237 C CH2 . TRP C 1 129 ? 111.438 -25.450 -8.959 1.00 54.62 ? 453 TRP C CH2 1 ATOM 4238 N N . PRO C 1 130 ? 111.555 -25.655 -15.093 1.00 54.31 ? 454 PRO C N 1 ATOM 4239 C CA . PRO C 1 130 ? 112.390 -26.676 -15.698 1.00 55.01 ? 454 PRO C CA 1 ATOM 4240 C C . PRO C 1 130 ? 111.632 -27.993 -15.744 1.00 55.50 ? 454 PRO C C 1 ATOM 4241 O O . PRO C 1 130 ? 111.361 -28.602 -14.706 1.00 55.58 ? 454 PRO C O 1 ATOM 4242 C CB . PRO C 1 130 ? 113.577 -26.775 -14.736 1.00 55.48 ? 454 PRO C CB 1 ATOM 4243 C CG . PRO C 1 130 ? 113.658 -25.442 -14.085 1.00 55.49 ? 454 PRO C CG 1 ATOM 4244 C CD . PRO C 1 130 ? 112.254 -24.921 -14.023 1.00 55.33 ? 454 PRO C CD 1 ATOM 4245 N N . GLY C 1 131 ? 111.274 -28.421 -16.945 1.00 55.61 ? 455 GLY C N 1 ATOM 4246 C CA . GLY C 1 131 ? 110.578 -29.682 -17.096 1.00 56.26 ? 455 GLY C CA 1 ATOM 4247 C C . GLY C 1 131 ? 109.525 -29.562 -18.168 1.00 56.70 ? 455 GLY C C 1 ATOM 4248 O O . GLY C 1 131 ? 109.687 -30.101 -19.266 1.00 56.66 ? 455 GLY C O 1 ATOM 4249 N N . SER C 1 132 ? 108.455 -28.838 -17.844 1.00 57.37 ? 456 SER C N 1 ATOM 4250 C CA . SER C 1 132 ? 107.265 -28.777 -18.691 1.00 57.35 ? 456 SER C CA 1 ATOM 4251 C C . SER C 1 132 ? 106.992 -27.361 -19.200 1.00 56.53 ? 456 SER C C 1 ATOM 4252 O O . SER C 1 132 ? 106.460 -26.508 -18.478 1.00 56.32 ? 456 SER C O 1 ATOM 4253 C CB . SER C 1 132 ? 106.057 -29.298 -17.916 1.00 57.89 ? 456 SER C CB 1 ATOM 4254 O OG . SER C 1 132 ? 105.983 -28.649 -16.660 1.00 58.42 ? 456 SER C OG 1 ATOM 4255 N N . ARG C 1 133 ? 107.355 -27.129 -20.459 1.00 54.97 ? 457 ARG C N 1 ATOM 4256 C CA . ARG C 1 133 ? 107.192 -25.815 -21.073 1.00 53.53 ? 457 ARG C CA 1 ATOM 4257 C C . ARG C 1 133 ? 105.824 -25.624 -21.692 1.00 48.41 ? 457 ARG C C 1 ATOM 4258 O O . ARG C 1 133 ? 105.496 -24.512 -22.056 1.00 47.36 ? 457 ARG C O 1 ATOM 4259 C CB . ARG C 1 133 ? 108.236 -25.561 -22.166 1.00 55.63 ? 457 ARG C CB 1 ATOM 4260 C CG . ARG C 1 133 ? 109.654 -25.823 -21.745 1.00 57.77 ? 457 ARG C CG 1 ATOM 4261 C CD . ARG C 1 133 ? 110.075 -27.205 -22.200 1.00 59.68 ? 457 ARG C CD 1 ATOM 4262 N NE . ARG C 1 133 ? 111.298 -27.633 -21.539 1.00 61.69 ? 457 ARG C NE 1 ATOM 4263 C CZ . ARG C 1 133 ? 112.025 -28.678 -21.923 1.00 64.09 ? 457 ARG C CZ 1 ATOM 4264 N NH1 . ARG C 1 133 ? 111.653 -29.405 -22.971 1.00 65.30 ? 457 ARG C NH1 1 ATOM 4265 N NH2 . ARG C 1 133 ? 113.129 -29.000 -21.261 1.00 64.37 ? 457 ARG C NH2 1 ATOM 4266 N N . ASP C 1 134 ? 105.037 -26.687 -21.818 1.00 44.96 ? 458 ASP C N 1 ATOM 4267 C CA . ASP C 1 134 ? 103.736 -26.598 -22.479 1.00 43.36 ? 458 ASP C CA 1 ATOM 4268 C C . ASP C 1 134 ? 102.549 -26.550 -21.520 1.00 42.39 ? 458 ASP C C 1 ATOM 4269 O O . ASP C 1 134 ? 101.410 -26.794 -21.931 1.00 42.82 ? 458 ASP C O 1 ATOM 4270 C CB . ASP C 1 134 ? 103.542 -27.764 -23.447 1.00 43.38 ? 458 ASP C CB 1 ATOM 4271 C CG . ASP C 1 134 ? 104.515 -27.720 -24.627 1.00 43.65 ? 458 ASP C CG 1 ATOM 4272 O OD1 . ASP C 1 134 ? 105.181 -26.673 -24.836 1.00 41.75 ? 458 ASP C OD1 1 ATOM 4273 O OD2 . ASP C 1 134 ? 104.605 -28.752 -25.335 1.00 43.45 ? 458 ASP C OD2 1 ATOM 4274 N N . LYS C 1 135 ? 102.823 -26.243 -20.255 1.00 39.99 ? 459 LYS C N 1 ATOM 4275 C CA . LYS C 1 135 ? 101.808 -26.157 -19.221 1.00 38.74 ? 459 LYS C CA 1 ATOM 4276 C C . LYS C 1 135 ? 102.265 -25.144 -18.199 1.00 35.19 ? 459 LYS C C 1 ATOM 4277 O O . LYS C 1 135 ? 103.451 -25.010 -17.928 1.00 35.44 ? 459 LYS C O 1 ATOM 4278 C CB . LYS C 1 135 ? 101.578 -27.507 -18.555 1.00 41.72 ? 459 LYS C CB 1 ATOM 4279 C CG . LYS C 1 135 ? 100.737 -28.439 -19.419 1.00 44.88 ? 459 LYS C CG 1 ATOM 4280 C CD . LYS C 1 135 ? 100.699 -29.879 -18.892 1.00 47.42 ? 459 LYS C CD 1 ATOM 4281 C CE . LYS C 1 135 ? 100.054 -30.842 -19.904 1.00 48.30 ? 459 LYS C CE 1 ATOM 4282 N NZ . LYS C 1 135 ? 100.442 -32.266 -19.614 1.00 49.23 ? 459 LYS C NZ 1 ATOM 4283 N N . ARG C 1 136 ? 101.314 -24.401 -17.656 1.00 31.93 ? 460 ARG C N 1 ATOM 4284 C CA . ARG C 1 136 ? 101.605 -23.415 -16.627 1.00 29.20 ? 460 ARG C CA 1 ATOM 4285 C C . ARG C 1 136 ? 100.558 -23.510 -15.533 1.00 25.72 ? 460 ARG C C 1 ATOM 4286 O O . ARG C 1 136 ? 99.438 -23.947 -15.772 1.00 24.19 ? 460 ARG C O 1 ATOM 4287 C CB . ARG C 1 136 ? 101.548 -22.013 -17.215 1.00 30.52 ? 460 ARG C CB 1 ATOM 4288 C CG . ARG C 1 136 ? 102.685 -21.643 -18.124 1.00 32.67 ? 460 ARG C CG 1 ATOM 4289 C CD . ARG C 1 136 ? 103.980 -21.426 -17.373 1.00 34.07 ? 460 ARG C CD 1 ATOM 4290 N NE . ARG C 1 136 ? 104.942 -20.800 -18.268 1.00 35.09 ? 460 ARG C NE 1 ATOM 4291 C CZ . ARG C 1 136 ? 105.328 -19.535 -18.164 1.00 37.22 ? 460 ARG C CZ 1 ATOM 4292 N NH1 . ARG C 1 136 ? 104.859 -18.754 -17.192 1.00 37.21 ? 460 ARG C NH1 1 ATOM 4293 N NH2 . ARG C 1 136 ? 106.211 -19.055 -19.028 1.00 38.69 ? 460 ARG C NH2 1 ATOM 4294 N N . THR C 1 137 ? 100.892 -23.074 -14.327 1.00 24.03 ? 461 THR C N 1 ATOM 4295 C CA . THR C 1 137 ? 99.894 -23.120 -13.285 1.00 21.92 ? 461 THR C CA 1 ATOM 4296 C C . THR C 1 137 ? 99.472 -21.717 -12.952 1.00 22.22 ? 461 THR C C 1 ATOM 4297 O O . THR C 1 137 ? 100.320 -20.859 -12.686 1.00 26.01 ? 461 THR C O 1 ATOM 4298 C CB . THR C 1 137 ? 100.375 -23.857 -12.026 1.00 19.25 ? 461 THR C CB 1 ATOM 4299 O OG1 . THR C 1 137 ? 100.771 -25.176 -12.387 1.00 20.59 ? 461 THR C OG1 1 ATOM 4300 C CG2 . THR C 1 137 ? 99.232 -24.000 -11.028 1.00 17.86 ? 461 THR C CG2 1 ATOM 4301 N N . LEU C 1 138 ? 98.165 -21.484 -12.932 1.00 19.16 ? 462 LEU C N 1 ATOM 4302 C CA . LEU C 1 138 ? 97.662 -20.230 -12.403 1.00 16.98 ? 462 LEU C CA 1 ATOM 4303 C C . LEU C 1 138 ? 97.065 -20.390 -11.019 1.00 18.69 ? 462 LEU C C 1 ATOM 4304 O O . LEU C 1 138 ? 96.464 -21.425 -10.699 1.00 20.80 ? 462 LEU C O 1 ATOM 4305 C CB . LEU C 1 138 ? 96.587 -19.639 -13.301 1.00 15.49 ? 462 LEU C CB 1 ATOM 4306 C CG . LEU C 1 138 ? 96.917 -19.568 -14.769 1.00 15.11 ? 462 LEU C CG 1 ATOM 4307 C CD1 . LEU C 1 138 ? 95.726 -18.930 -15.460 1.00 13.92 ? 462 LEU C CD1 1 ATOM 4308 C CD2 . LEU C 1 138 ? 98.189 -18.789 -14.929 1.00 13.59 ? 462 LEU C CD2 1 ATOM 4309 N N . ALA C 1 139 ? 97.203 -19.345 -10.206 1.00 18.94 ? 463 ALA C N 1 ATOM 4310 C CA . ALA C 1 139 ? 96.798 -19.434 -8.807 1.00 19.58 ? 463 ALA C CA 1 ATOM 4311 C C . ALA C 1 139 ? 96.081 -18.161 -8.421 1.00 21.19 ? 463 ALA C C 1 ATOM 4312 O O . ALA C 1 139 ? 96.419 -17.071 -8.867 1.00 23.36 ? 463 ALA C O 1 ATOM 4313 C CB . ALA C 1 139 ? 97.989 -19.627 -7.923 1.00 17.01 ? 463 ALA C CB 1 ATOM 4314 N N . CYS C 1 140 ? 95.066 -18.296 -7.591 1.00 21.68 ? 464 CYS C N 1 ATOM 4315 C CA . CYS C 1 140 ? 94.279 -17.143 -7.241 1.00 21.88 ? 464 CYS C CA 1 ATOM 4316 C C . CYS C 1 140 ? 94.041 -17.221 -5.759 1.00 22.03 ? 464 CYS C C 1 ATOM 4317 O O . CYS C 1 140 ? 93.780 -18.294 -5.198 1.00 22.62 ? 464 CYS C O 1 ATOM 4318 C CB . CYS C 1 140 ? 92.973 -17.189 -8.003 1.00 22.98 ? 464 CYS C CB 1 ATOM 4319 S SG . CYS C 1 140 ? 91.926 -15.765 -7.807 1.00 23.86 ? 464 CYS C SG 1 ATOM 4320 N N . LEU C 1 141 ? 94.170 -16.075 -5.118 1.00 21.91 ? 465 LEU C N 1 ATOM 4321 C CA . LEU C 1 141 ? 94.032 -16.004 -3.678 1.00 21.28 ? 465 LEU C CA 1 ATOM 4322 C C . LEU C 1 141 ? 92.891 -15.066 -3.403 1.00 21.72 ? 465 LEU C C 1 ATOM 4323 O O . LEU C 1 141 ? 92.970 -13.910 -3.813 1.00 23.86 ? 465 LEU C O 1 ATOM 4324 C CB . LEU C 1 141 ? 95.271 -15.375 -3.060 1.00 20.13 ? 465 LEU C CB 1 ATOM 4325 C CG . LEU C 1 141 ? 95.146 -15.009 -1.592 1.00 20.64 ? 465 LEU C CG 1 ATOM 4326 C CD1 . LEU C 1 141 ? 94.680 -16.273 -0.880 1.00 19.96 ? 465 LEU C CD1 1 ATOM 4327 C CD2 . LEU C 1 141 ? 96.489 -14.477 -1.009 1.00 21.03 ? 465 LEU C CD2 1 ATOM 4328 N N . ILE C 1 142 ? 91.862 -15.547 -2.709 1.00 19.90 ? 466 ILE C N 1 ATOM 4329 C CA . ILE C 1 142 ? 90.704 -14.725 -2.414 1.00 20.95 ? 466 ILE C CA 1 ATOM 4330 C C . ILE C 1 142 ? 90.570 -14.716 -0.920 1.00 21.06 ? 466 ILE C C 1 ATOM 4331 O O . ILE C 1 142 ? 90.553 -15.784 -0.312 1.00 23.44 ? 466 ILE C O 1 ATOM 4332 C CB . ILE C 1 142 ? 89.430 -15.302 -3.067 1.00 21.54 ? 466 ILE C CB 1 ATOM 4333 C CG1 . ILE C 1 142 ? 89.673 -15.489 -4.561 1.00 21.45 ? 466 ILE C CG1 1 ATOM 4334 C CG2 . ILE C 1 142 ? 88.186 -14.435 -2.808 1.00 19.06 ? 466 ILE C CG2 1 ATOM 4335 C CD1 . ILE C 1 142 ? 88.791 -16.547 -5.164 1.00 23.93 ? 466 ILE C CD1 1 ATOM 4336 N N . GLN C 1 143 ? 90.480 -13.531 -0.333 1.00 19.97 ? 467 GLN C N 1 ATOM 4337 C CA . GLN C 1 143 ? 90.737 -13.399 1.094 1.00 22.07 ? 467 GLN C CA 1 ATOM 4338 C C . GLN C 1 143 ? 90.025 -12.200 1.717 1.00 22.35 ? 467 GLN C C 1 ATOM 4339 O O . GLN C 1 143 ? 89.613 -11.283 1.019 1.00 23.80 ? 467 GLN C O 1 ATOM 4340 C CB . GLN C 1 143 ? 92.251 -13.293 1.335 1.00 22.33 ? 467 GLN C CB 1 ATOM 4341 C CG . GLN C 1 143 ? 92.902 -12.003 0.832 1.00 22.78 ? 467 GLN C CG 1 ATOM 4342 C CD . GLN C 1 143 ? 94.335 -11.805 1.335 1.00 23.17 ? 467 GLN C CD 1 ATOM 4343 O OE1 . GLN C 1 143 ? 95.060 -12.770 1.590 1.00 24.81 ? 467 GLN C OE1 1 ATOM 4344 N NE2 . GLN C 1 143 ? 94.746 -10.547 1.468 1.00 19.29 ? 467 GLN C NE2 1 ATOM 4345 N N . ASN C 1 144 ? 89.901 -12.229 3.036 1.00 24.29 ? 468 ASN C N 1 ATOM 4346 C CA . ASN C 1 144 ? 89.330 -11.137 3.853 1.00 26.90 ? 468 ASN C CA 1 ATOM 4347 C C . ASN C 1 144 ? 87.831 -10.922 3.600 1.00 26.30 ? 468 ASN C C 1 ATOM 4348 O O . ASN C 1 144 ? 87.295 -9.864 3.911 1.00 26.49 ? 468 ASN C O 1 ATOM 4349 C CB . ASN C 1 144 ? 90.095 -9.805 3.697 1.00 27.44 ? 468 ASN C CB 1 ATOM 4350 C CG . ASN C 1 144 ? 91.545 -9.882 4.172 1.00 29.00 ? 468 ASN C CG 1 ATOM 4351 O OD1 . ASN C 1 144 ? 91.900 -10.767 4.944 1.00 30.03 ? 468 ASN C OD1 1 ATOM 4352 N ND2 . ASN C 1 144 ? 92.389 -8.954 3.701 1.00 27.68 ? 468 ASN C ND2 1 ATOM 4353 N N . PHE C 1 145 ? 87.155 -11.919 3.036 1.00 25.19 ? 469 PHE C N 1 ATOM 4354 C CA . PHE C 1 145 ? 85.693 -11.849 2.897 1.00 24.53 ? 469 PHE C CA 1 ATOM 4355 C C . PHE C 1 145 ? 84.948 -12.465 4.099 1.00 23.72 ? 469 PHE C C 1 ATOM 4356 O O . PHE C 1 145 ? 85.420 -13.412 4.733 1.00 22.79 ? 469 PHE C O 1 ATOM 4357 C CB . PHE C 1 145 ? 85.229 -12.530 1.610 1.00 22.75 ? 469 PHE C CB 1 ATOM 4358 C CG . PHE C 1 145 ? 85.727 -13.937 1.450 1.00 22.59 ? 469 PHE C CG 1 ATOM 4359 C CD1 . PHE C 1 145 ? 84.962 -14.999 1.861 1.00 22.84 ? 469 PHE C CD1 1 ATOM 4360 C CD2 . PHE C 1 145 ? 86.955 -14.203 0.874 1.00 23.21 ? 469 PHE C CD2 1 ATOM 4361 C CE1 . PHE C 1 145 ? 85.399 -16.304 1.715 1.00 21.92 ? 469 PHE C CE1 1 ATOM 4362 C CE2 . PHE C 1 145 ? 87.387 -15.490 0.736 1.00 23.08 ? 469 PHE C CE2 1 ATOM 4363 C CZ . PHE C 1 145 ? 86.608 -16.548 1.168 1.00 21.65 ? 469 PHE C CZ 1 ATOM 4364 N N . MET C 1 146 ? 83.783 -11.925 4.405 1.00 21.94 ? 470 MET C N 1 ATOM 4365 C CA . MET C 1 146 ? 82.867 -12.597 5.321 1.00 24.58 ? 470 MET C CA 1 ATOM 4366 C C . MET C 1 146 ? 81.431 -12.325 4.890 1.00 23.18 ? 470 MET C C 1 ATOM 4367 O O . MET C 1 146 ? 81.121 -11.246 4.380 1.00 23.71 ? 470 MET C O 1 ATOM 4368 C CB . MET C 1 146 ? 83.111 -12.220 6.802 1.00 25.37 ? 470 MET C CB 1 ATOM 4369 C CG . MET C 1 146 ? 83.453 -10.773 7.110 1.00 26.66 ? 470 MET C CG 1 ATOM 4370 S SD . MET C 1 146 ? 84.131 -10.491 8.790 1.00 28.36 ? 470 MET C SD 1 ATOM 4371 C CE . MET C 1 146 ? 82.780 -11.094 9.806 1.00 28.11 ? 470 MET C CE 1 ATOM 4372 N N . PRO C 1 147 ? 80.545 -13.301 5.072 1.00 22.45 ? 471 PRO C N 1 ATOM 4373 C CA . PRO C 1 147 ? 80.771 -14.618 5.625 1.00 22.85 ? 471 PRO C CA 1 ATOM 4374 C C . PRO C 1 147 ? 81.548 -15.487 4.641 1.00 24.06 ? 471 PRO C C 1 ATOM 4375 O O . PRO C 1 147 ? 82.088 -14.950 3.664 1.00 23.42 ? 471 PRO C O 1 ATOM 4376 C CB . PRO C 1 147 ? 79.363 -15.136 5.901 1.00 23.33 ? 471 PRO C CB 1 ATOM 4377 C CG . PRO C 1 147 ? 78.463 -14.328 4.998 1.00 24.79 ? 471 PRO C CG 1 ATOM 4378 C CD . PRO C 1 147 ? 79.125 -13.016 4.804 1.00 24.58 ? 471 PRO C CD 1 ATOM 4379 N N . GLU C 1 148 ? 81.629 -16.795 4.892 1.00 23.81 ? 472 GLU C N 1 ATOM 4380 C CA . GLU C 1 148 ? 82.588 -17.631 4.184 1.00 25.42 ? 472 GLU C CA 1 ATOM 4381 C C . GLU C 1 148 ? 82.111 -18.170 2.847 1.00 24.10 ? 472 GLU C C 1 ATOM 4382 O O . GLU C 1 148 ? 82.915 -18.646 2.034 1.00 20.72 ? 472 GLU C O 1 ATOM 4383 C CB . GLU C 1 148 ? 83.026 -18.814 5.045 1.00 28.21 ? 472 GLU C CB 1 ATOM 4384 C CG . GLU C 1 148 ? 82.031 -19.930 5.062 1.00 30.58 ? 472 GLU C CG 1 ATOM 4385 C CD . GLU C 1 148 ? 82.436 -21.035 5.981 1.00 33.10 ? 472 GLU C CD 1 ATOM 4386 O OE1 . GLU C 1 148 ? 82.709 -20.740 7.169 1.00 36.43 ? 472 GLU C OE1 1 ATOM 4387 O OE2 . GLU C 1 148 ? 82.465 -22.194 5.502 1.00 35.87 ? 472 GLU C OE2 1 ATOM 4388 N N . ASP C 1 149 ? 80.808 -18.120 2.619 1.00 22.71 ? 473 ASP C N 1 ATOM 4389 C CA . ASP C 1 149 ? 80.278 -18.678 1.390 1.00 21.97 ? 473 ASP C CA 1 ATOM 4390 C C . ASP C 1 149 ? 80.789 -17.873 0.196 1.00 21.58 ? 473 ASP C C 1 ATOM 4391 O O . ASP C 1 149 ? 80.525 -16.677 0.052 1.00 20.27 ? 473 ASP C O 1 ATOM 4392 C CB . ASP C 1 149 ? 78.762 -18.638 1.429 1.00 23.73 ? 473 ASP C CB 1 ATOM 4393 C CG . ASP C 1 149 ? 78.179 -19.503 2.528 1.00 24.84 ? 473 ASP C CG 1 ATOM 4394 O OD1 . ASP C 1 149 ? 78.699 -20.602 2.828 1.00 26.10 ? 473 ASP C OD1 1 ATOM 4395 O OD2 . ASP C 1 149 ? 77.179 -19.062 3.098 1.00 24.68 ? 473 ASP C OD2 1 ATOM 4396 N N . ILE C 1 150 ? 81.531 -18.543 -0.674 1.00 20.90 ? 474 ILE C N 1 ATOM 4397 C CA . ILE C 1 150 ? 82.015 -17.911 -1.882 1.00 19.75 ? 474 ILE C CA 1 ATOM 4398 C C . ILE C 1 150 ? 82.038 -18.894 -3.047 1.00 19.78 ? 474 ILE C C 1 ATOM 4399 O O . ILE C 1 150 ? 82.321 -20.048 -2.854 1.00 19.54 ? 474 ILE C O 1 ATOM 4400 C CB . ILE C 1 150 ? 83.412 -17.356 -1.623 1.00 18.17 ? 474 ILE C CB 1 ATOM 4401 C CG1 . ILE C 1 150 ? 83.729 -16.229 -2.599 1.00 17.52 ? 474 ILE C CG1 1 ATOM 4402 C CG2 . ILE C 1 150 ? 84.417 -18.457 -1.617 1.00 16.45 ? 474 ILE C CG2 1 ATOM 4403 C CD1 . ILE C 1 150 ? 84.984 -15.514 -2.198 1.00 18.57 ? 474 ILE C CD1 1 ATOM 4404 N N . SER C 1 151 ? 81.732 -18.432 -4.256 1.00 20.23 ? 475 SER C N 1 ATOM 4405 C CA . SER C 1 151 ? 81.914 -19.243 -5.450 1.00 18.06 ? 475 SER C CA 1 ATOM 4406 C C . SER C 1 151 ? 83.104 -18.731 -6.215 1.00 18.65 ? 475 SER C C 1 ATOM 4407 O O . SER C 1 151 ? 83.277 -17.516 -6.376 1.00 17.18 ? 475 SER C O 1 ATOM 4408 C CB . SER C 1 151 ? 80.696 -19.151 -6.359 1.00 17.96 ? 475 SER C CB 1 ATOM 4409 O OG . SER C 1 151 ? 79.624 -19.831 -5.750 1.00 22.98 ? 475 SER C OG 1 ATOM 4410 N N . VAL C 1 152 ? 83.921 -19.657 -6.707 1.00 18.65 ? 476 VAL C N 1 ATOM 4411 C CA . VAL C 1 152 ? 85.085 -19.279 -7.489 1.00 16.87 ? 476 VAL C CA 1 ATOM 4412 C C . VAL C 1 152 ? 85.022 -19.924 -8.845 1.00 18.21 ? 476 VAL C C 1 ATOM 4413 O O . VAL C 1 152 ? 84.758 -21.139 -8.963 1.00 16.63 ? 476 VAL C O 1 ATOM 4414 C CB . VAL C 1 152 ? 86.361 -19.791 -6.878 1.00 17.45 ? 476 VAL C CB 1 ATOM 4415 C CG1 . VAL C 1 152 ? 87.544 -19.294 -7.740 1.00 17.20 ? 476 VAL C CG1 1 ATOM 4416 C CG2 . VAL C 1 152 ? 86.479 -19.328 -5.436 1.00 16.92 ? 476 VAL C CG2 1 ATOM 4417 N N . GLN C 1 153 ? 85.285 -19.130 -9.878 1.00 20.05 ? 477 GLN C N 1 ATOM 4418 C CA . GLN C 1 153 ? 85.290 -19.710 -11.210 1.00 22.55 ? 477 GLN C CA 1 ATOM 4419 C C . GLN C 1 153 ? 86.393 -19.132 -12.080 1.00 22.13 ? 477 GLN C C 1 ATOM 4420 O O . GLN C 1 153 ? 86.876 -18.045 -11.800 1.00 21.57 ? 477 GLN C O 1 ATOM 4421 C CB . GLN C 1 153 ? 83.917 -19.612 -11.836 1.00 25.66 ? 477 GLN C CB 1 ATOM 4422 C CG . GLN C 1 153 ? 83.373 -18.235 -11.846 1.00 29.83 ? 477 GLN C CG 1 ATOM 4423 C CD . GLN C 1 153 ? 81.878 -18.247 -12.013 1.00 31.50 ? 477 GLN C CD 1 ATOM 4424 O OE1 . GLN C 1 153 ? 81.291 -17.358 -12.640 1.00 33.20 ? 477 GLN C OE1 1 ATOM 4425 N NE2 . GLN C 1 153 ? 81.253 -19.270 -11.458 1.00 33.33 ? 477 GLN C NE2 1 ATOM 4426 N N . TRP C 1 154 ? 86.846 -19.884 -13.084 1.00 20.59 ? 478 TRP C N 1 ATOM 4427 C CA . TRP C 1 154 ? 87.877 -19.371 -13.969 1.00 20.17 ? 478 TRP C CA 1 ATOM 4428 C C . TRP C 1 154 ? 87.297 -19.204 -15.345 1.00 18.33 ? 478 TRP C C 1 ATOM 4429 O O . TRP C 1 154 ? 86.484 -20.008 -15.773 1.00 18.99 ? 478 TRP C O 1 ATOM 4430 C CB . TRP C 1 154 ? 89.083 -20.302 -14.057 1.00 20.00 ? 478 TRP C CB 1 ATOM 4431 C CG . TRP C 1 154 ? 89.922 -20.345 -12.837 1.00 20.79 ? 478 TRP C CG 1 ATOM 4432 C CD1 . TRP C 1 154 ? 89.702 -21.112 -11.731 1.00 21.38 ? 478 TRP C CD1 1 ATOM 4433 C CD2 . TRP C 1 154 ? 91.136 -19.612 -12.583 1.00 20.39 ? 478 TRP C CD2 1 ATOM 4434 N NE1 . TRP C 1 154 ? 90.690 -20.887 -10.798 1.00 21.54 ? 478 TRP C NE1 1 ATOM 4435 C CE2 . TRP C 1 154 ? 91.585 -19.982 -11.306 1.00 20.50 ? 478 TRP C CE2 1 ATOM 4436 C CE3 . TRP C 1 154 ? 91.878 -18.675 -13.307 1.00 20.07 ? 478 TRP C CE3 1 ATOM 4437 C CZ2 . TRP C 1 154 ? 92.739 -19.459 -10.752 1.00 19.45 ? 478 TRP C CZ2 1 ATOM 4438 C CZ3 . TRP C 1 154 ? 93.003 -18.148 -12.747 1.00 18.53 ? 478 TRP C CZ3 1 ATOM 4439 C CH2 . TRP C 1 154 ? 93.431 -18.547 -11.492 1.00 19.29 ? 478 TRP C CH2 1 ATOM 4440 N N . LEU C 1 155 ? 87.737 -18.178 -16.057 1.00 17.58 ? 479 LEU C N 1 ATOM 4441 C CA . LEU C 1 155 ? 87.214 -17.964 -17.412 1.00 18.95 ? 479 LEU C CA 1 ATOM 4442 C C . LEU C 1 155 ? 88.343 -17.710 -18.382 1.00 16.59 ? 479 LEU C C 1 ATOM 4443 O O . LEU C 1 155 ? 89.439 -17.323 -17.960 1.00 17.32 ? 479 LEU C O 1 ATOM 4444 C CB . LEU C 1 155 ? 86.226 -16.789 -17.467 1.00 18.69 ? 479 LEU C CB 1 ATOM 4445 C CG . LEU C 1 155 ? 84.983 -16.870 -16.565 1.00 18.50 ? 479 LEU C CG 1 ATOM 4446 C CD1 . LEU C 1 155 ? 85.324 -16.220 -15.260 1.00 16.22 ? 479 LEU C CD1 1 ATOM 4447 C CD2 . LEU C 1 155 ? 83.722 -16.158 -17.161 1.00 18.58 ? 479 LEU C CD2 1 ATOM 4448 N N . HIS C 1 156 ? 88.069 -17.914 -19.667 1.00 14.69 ? 480 HIS C N 1 ATOM 4449 C CA . HIS C 1 156 ? 89.044 -17.720 -20.743 1.00 17.11 ? 480 HIS C CA 1 ATOM 4450 C C . HIS C 1 156 ? 88.229 -17.333 -21.973 1.00 19.00 ? 480 HIS C C 1 ATOM 4451 O O . HIS C 1 156 ? 87.314 -18.061 -22.346 1.00 18.75 ? 480 HIS C O 1 ATOM 4452 C CB . HIS C 1 156 ? 89.844 -19.007 -20.969 1.00 17.33 ? 480 HIS C CB 1 ATOM 4453 C CG . HIS C 1 156 ? 91.000 -18.867 -21.916 1.00 19.10 ? 480 HIS C CG 1 ATOM 4454 N ND1 . HIS C 1 156 ? 91.195 -19.729 -22.978 1.00 19.08 ? 480 HIS C ND1 1 ATOM 4455 C CD2 . HIS C 1 156 ? 92.034 -17.992 -21.954 1.00 18.55 ? 480 HIS C CD2 1 ATOM 4456 C CE1 . HIS C 1 156 ? 92.285 -19.376 -23.637 1.00 17.12 ? 480 HIS C CE1 1 ATOM 4457 N NE2 . HIS C 1 156 ? 92.819 -18.331 -23.034 1.00 16.03 ? 480 HIS C NE2 1 ATOM 4458 N N . ASN C 1 157 ? 88.520 -16.165 -22.560 1.00 19.46 ? 481 ASN C N 1 ATOM 4459 C CA . ASN C 1 157 ? 87.716 -15.623 -23.650 1.00 19.47 ? 481 ASN C CA 1 ATOM 4460 C C . ASN C 1 157 ? 86.283 -15.419 -23.174 1.00 19.12 ? 481 ASN C C 1 ATOM 4461 O O . ASN C 1 157 ? 85.319 -15.467 -23.927 1.00 18.34 ? 481 ASN C O 1 ATOM 4462 C CB . ASN C 1 157 ? 87.716 -16.517 -24.891 1.00 19.26 ? 481 ASN C CB 1 ATOM 4463 C CG . ASN C 1 157 ? 89.101 -16.842 -25.374 1.00 20.49 ? 481 ASN C CG 1 ATOM 4464 O OD1 . ASN C 1 157 ? 89.899 -15.959 -25.693 1.00 19.51 ? 481 ASN C OD1 1 ATOM 4465 N ND2 . ASN C 1 157 ? 89.395 -18.130 -25.444 1.00 21.73 ? 481 ASN C ND2 1 ATOM 4466 N N . GLU C 1 158 ? 86.154 -15.170 -21.892 1.00 21.00 ? 482 GLU C N 1 ATOM 4467 C CA . GLU C 1 158 ? 84.852 -14.919 -21.312 1.00 24.14 ? 482 GLU C CA 1 ATOM 4468 C C . GLU C 1 158 ? 83.959 -16.145 -21.391 1.00 24.64 ? 482 GLU C C 1 ATOM 4469 O O . GLU C 1 158 ? 82.757 -16.022 -21.246 1.00 23.84 ? 482 GLU C O 1 ATOM 4470 C CB . GLU C 1 158 ? 84.213 -13.712 -21.982 1.00 26.60 ? 482 GLU C CB 1 ATOM 4471 C CG . GLU C 1 158 ? 83.293 -12.935 -21.098 1.00 30.03 ? 482 GLU C CG 1 ATOM 4472 C CD . GLU C 1 158 ? 83.937 -12.457 -19.798 1.00 32.42 ? 482 GLU C CD 1 ATOM 4473 O OE1 . GLU C 1 158 ? 85.189 -12.336 -19.744 1.00 34.01 ? 482 GLU C OE1 1 ATOM 4474 O OE2 . GLU C 1 158 ? 83.171 -12.214 -18.832 1.00 33.02 ? 482 GLU C OE2 1 ATOM 4475 N N . VAL C 1 159 ? 84.548 -17.326 -21.595 1.00 24.38 ? 483 VAL C N 1 ATOM 4476 C CA . VAL C 1 159 ? 83.802 -18.568 -21.459 1.00 24.62 ? 483 VAL C CA 1 ATOM 4477 C C . VAL C 1 159 ? 84.224 -19.273 -20.165 1.00 23.08 ? 483 VAL C C 1 ATOM 4478 O O . VAL C 1 159 ? 85.406 -19.360 -19.844 1.00 23.37 ? 483 VAL C O 1 ATOM 4479 C CB . VAL C 1 159 ? 84.028 -19.511 -22.676 1.00 26.55 ? 483 VAL C CB 1 ATOM 4480 C CG1 . VAL C 1 159 ? 85.439 -19.396 -23.192 1.00 27.19 ? 483 VAL C CG1 1 ATOM 4481 C CG2 . VAL C 1 159 ? 83.744 -20.977 -22.294 1.00 25.64 ? 483 VAL C CG2 1 ATOM 4482 N N . GLN C 1 160 ? 83.250 -19.762 -19.412 1.00 21.53 ? 484 GLN C N 1 ATOM 4483 C CA . GLN C 1 160 ? 83.509 -20.342 -18.119 1.00 21.18 ? 484 GLN C CA 1 ATOM 4484 C C . GLN C 1 160 ? 84.131 -21.702 -18.313 1.00 18.42 ? 484 GLN C C 1 ATOM 4485 O O . GLN C 1 160 ? 83.592 -22.524 -19.039 1.00 19.33 ? 484 GLN C O 1 ATOM 4486 C CB . GLN C 1 160 ? 82.213 -20.418 -17.313 1.00 25.45 ? 484 GLN C CB 1 ATOM 4487 C CG . GLN C 1 160 ? 82.444 -20.941 -15.902 1.00 30.69 ? 484 GLN C CG 1 ATOM 4488 C CD . GLN C 1 160 ? 81.307 -20.677 -14.936 1.00 33.68 ? 484 GLN C CD 1 ATOM 4489 O OE1 . GLN C 1 160 ? 80.717 -21.619 -14.391 1.00 37.10 ? 484 GLN C OE1 1 ATOM 4490 N NE2 . GLN C 1 160 ? 81.013 -19.400 -14.696 1.00 35.82 ? 484 GLN C NE2 1 ATOM 4491 N N . LEU C 1 161 ? 85.278 -21.951 -17.685 1.00 17.93 ? 485 LEU C N 1 ATOM 4492 C CA . LEU C 1 161 ? 85.942 -23.244 -17.815 1.00 16.60 ? 485 LEU C CA 1 ATOM 4493 C C . LEU C 1 161 ? 85.232 -24.302 -16.957 1.00 15.78 ? 485 LEU C C 1 ATOM 4494 O O . LEU C 1 161 ? 84.583 -23.968 -15.977 1.00 14.48 ? 485 LEU C O 1 ATOM 4495 C CB . LEU C 1 161 ? 87.414 -23.174 -17.432 1.00 16.63 ? 485 LEU C CB 1 ATOM 4496 C CG . LEU C 1 161 ? 88.326 -22.468 -18.443 1.00 17.46 ? 485 LEU C CG 1 ATOM 4497 C CD1 . LEU C 1 161 ? 89.732 -22.230 -17.861 1.00 14.01 ? 485 LEU C CD1 1 ATOM 4498 C CD2 . LEU C 1 161 ? 88.385 -23.191 -19.784 1.00 15.12 ? 485 LEU C CD2 1 ATOM 4499 N N . PRO C 1 162 ? 85.312 -25.578 -17.363 1.00 17.13 ? 486 PRO C N 1 ATOM 4500 C CA . PRO C 1 162 ? 84.698 -26.661 -16.632 1.00 18.59 ? 486 PRO C CA 1 ATOM 4501 C C . PRO C 1 162 ? 85.207 -26.729 -15.212 1.00 21.50 ? 486 PRO C C 1 ATOM 4502 O O . PRO C 1 162 ? 86.409 -26.627 -14.981 1.00 19.29 ? 486 PRO C O 1 ATOM 4503 C CB . PRO C 1 162 ? 85.147 -27.891 -17.408 1.00 18.80 ? 486 PRO C CB 1 ATOM 4504 C CG . PRO C 1 162 ? 85.317 -27.408 -18.784 1.00 17.99 ? 486 PRO C CG 1 ATOM 4505 C CD . PRO C 1 162 ? 85.841 -26.032 -18.659 1.00 17.54 ? 486 PRO C CD 1 ATOM 4506 N N . ASP C 1 163 ? 84.275 -26.921 -14.283 1.00 25.67 ? 487 ASP C N 1 ATOM 4507 C CA . ASP C 1 163 ? 84.589 -27.081 -12.863 1.00 27.16 ? 487 ASP C CA 1 ATOM 4508 C C . ASP C 1 163 ? 85.775 -28.021 -12.627 1.00 26.65 ? 487 ASP C C 1 ATOM 4509 O O . ASP C 1 163 ? 86.684 -27.685 -11.884 1.00 26.48 ? 487 ASP C O 1 ATOM 4510 C CB . ASP C 1 163 ? 83.328 -27.534 -12.109 1.00 29.41 ? 487 ASP C CB 1 ATOM 4511 C CG . ASP C 1 163 ? 82.299 -26.395 -11.939 1.00 31.54 ? 487 ASP C CG 1 ATOM 4512 O OD1 . ASP C 1 163 ? 82.678 -25.212 -12.067 1.00 34.69 ? 487 ASP C OD1 1 ATOM 4513 O OD2 . ASP C 1 163 ? 81.110 -26.657 -11.669 1.00 33.72 ? 487 ASP C OD2 1 ATOM 4514 N N . ALA C 1 164 ? 85.793 -29.176 -13.278 1.00 26.38 ? 488 ALA C N 1 ATOM 4515 C CA . ALA C 1 164 ? 86.874 -30.141 -13.078 1.00 27.88 ? 488 ALA C CA 1 ATOM 4516 C C . ALA C 1 164 ? 88.271 -29.594 -13.395 1.00 27.91 ? 488 ALA C C 1 ATOM 4517 O O . ALA C 1 164 ? 89.270 -30.217 -13.068 1.00 28.40 ? 488 ALA C O 1 ATOM 4518 C CB . ALA C 1 164 ? 86.628 -31.399 -13.917 1.00 26.66 ? 488 ALA C CB 1 ATOM 4519 N N . ARG C 1 165 ? 88.356 -28.453 -14.063 1.00 27.88 ? 489 ARG C N 1 ATOM 4520 C CA . ARG C 1 165 ? 89.649 -27.942 -14.489 1.00 27.34 ? 489 ARG C CA 1 ATOM 4521 C C . ARG C 1 165 ? 90.444 -27.344 -13.340 1.00 25.21 ? 489 ARG C C 1 ATOM 4522 O O . ARG C 1 165 ? 91.674 -27.325 -13.368 1.00 23.74 ? 489 ARG C O 1 ATOM 4523 C CB . ARG C 1 165 ? 89.442 -26.875 -15.553 1.00 29.49 ? 489 ARG C CB 1 ATOM 4524 C CG . ARG C 1 165 ? 89.325 -27.486 -16.903 1.00 30.44 ? 489 ARG C CG 1 ATOM 4525 C CD . ARG C 1 165 ? 90.684 -27.993 -17.379 1.00 31.39 ? 489 ARG C CD 1 ATOM 4526 N NE . ARG C 1 165 ? 90.806 -27.429 -18.708 1.00 33.70 ? 489 ARG C NE 1 ATOM 4527 C CZ . ARG C 1 165 ? 91.624 -26.451 -19.066 1.00 34.07 ? 489 ARG C CZ 1 ATOM 4528 N NH1 . ARG C 1 165 ? 92.508 -25.945 -18.230 1.00 33.71 ? 489 ARG C NH1 1 ATOM 4529 N NH2 . ARG C 1 165 ? 91.576 -26.012 -20.311 1.00 35.47 ? 489 ARG C NH2 1 ATOM 4530 N N . HIS C 1 166 ? 89.719 -26.875 -12.333 1.00 23.85 ? 490 HIS C N 1 ATOM 4531 C CA . HIS C 1 166 ? 90.320 -26.230 -11.176 1.00 24.16 ? 490 HIS C CA 1 ATOM 4532 C C . HIS C 1 166 ? 89.926 -26.878 -9.853 1.00 24.06 ? 490 HIS C C 1 ATOM 4533 O O . HIS C 1 166 ? 88.995 -27.670 -9.740 1.00 20.86 ? 490 HIS C O 1 ATOM 4534 C CB . HIS C 1 166 ? 89.972 -24.728 -11.143 1.00 23.18 ? 490 HIS C CB 1 ATOM 4535 C CG . HIS C 1 166 ? 88.551 -24.453 -10.780 1.00 24.66 ? 490 HIS C CG 1 ATOM 4536 N ND1 . HIS C 1 166 ? 87.555 -24.312 -11.723 1.00 25.65 ? 490 HIS C ND1 1 ATOM 4537 C CD2 . HIS C 1 166 ? 87.956 -24.294 -9.573 1.00 25.89 ? 490 HIS C CD2 1 ATOM 4538 C CE1 . HIS C 1 166 ? 86.408 -24.081 -11.110 1.00 25.32 ? 490 HIS C CE1 1 ATOM 4539 N NE2 . HIS C 1 166 ? 86.622 -24.071 -9.807 1.00 25.46 ? 490 HIS C NE2 1 ATOM 4540 N N . SER C 1 167 ? 90.668 -26.476 -8.838 1.00 26.25 ? 491 SER C N 1 ATOM 4541 C CA . SER C 1 167 ? 90.551 -27.005 -7.505 1.00 26.38 ? 491 SER C CA 1 ATOM 4542 C C . SER C 1 167 ? 90.541 -25.791 -6.601 1.00 26.95 ? 491 SER C C 1 ATOM 4543 O O . SER C 1 167 ? 91.445 -24.965 -6.668 1.00 27.49 ? 491 SER C O 1 ATOM 4544 C CB . SER C 1 167 ? 91.798 -27.804 -7.231 1.00 27.54 ? 491 SER C CB 1 ATOM 4545 O OG . SER C 1 167 ? 91.674 -28.385 -5.974 1.00 34.12 ? 491 SER C OG 1 ATOM 4546 N N . THR C 1 168 ? 89.509 -25.656 -5.775 1.00 27.65 ? 492 THR C N 1 ATOM 4547 C CA . THR C 1 168 ? 89.437 -24.543 -4.845 1.00 26.22 ? 492 THR C CA 1 ATOM 4548 C C . THR C 1 168 ? 89.431 -25.066 -3.411 1.00 25.42 ? 492 THR C C 1 ATOM 4549 O O . THR C 1 168 ? 88.670 -25.959 -3.069 1.00 23.85 ? 492 THR C O 1 ATOM 4550 C CB . THR C 1 168 ? 88.201 -23.685 -5.120 1.00 27.14 ? 492 THR C CB 1 ATOM 4551 O OG1 . THR C 1 168 ? 88.363 -23.018 -6.380 1.00 26.04 ? 492 THR C OG1 1 ATOM 4552 C CG2 . THR C 1 168 ? 88.004 -22.653 -4.004 1.00 26.52 ? 492 THR C CG2 1 ATOM 4553 N N . THR C 1 169 ? 90.305 -24.522 -2.575 1.00 24.87 ? 493 THR C N 1 ATOM 4554 C CA . THR C 1 169 ? 90.368 -24.934 -1.164 1.00 26.41 ? 493 THR C CA 1 ATOM 4555 C C . THR C 1 169 ? 89.150 -24.471 -0.379 1.00 26.46 ? 493 THR C C 1 ATOM 4556 O O . THR C 1 169 ? 88.403 -23.607 -0.815 1.00 27.60 ? 493 THR C O 1 ATOM 4557 C CB . THR C 1 169 ? 91.592 -24.364 -0.435 1.00 25.32 ? 493 THR C CB 1 ATOM 4558 O OG1 . THR C 1 169 ? 91.477 -22.937 -0.368 1.00 26.28 ? 493 THR C OG1 1 ATOM 4559 C CG2 . THR C 1 169 ? 92.866 -24.735 -1.170 1.00 25.76 ? 493 THR C CG2 1 ATOM 4560 N N . GLN C 1 170 ? 88.949 -25.057 0.785 1.00 27.95 ? 494 GLN C N 1 ATOM 4561 C CA . GLN C 1 170 ? 87.772 -24.727 1.577 1.00 31.88 ? 494 GLN C CA 1 ATOM 4562 C C . GLN C 1 170 ? 88.068 -23.442 2.377 1.00 28.05 ? 494 GLN C C 1 ATOM 4563 O O . GLN C 1 170 ? 89.202 -23.195 2.794 1.00 25.23 ? 494 GLN C O 1 ATOM 4564 C CB . GLN C 1 170 ? 87.375 -25.901 2.508 1.00 35.62 ? 494 GLN C CB 1 ATOM 4565 C CG . GLN C 1 170 ? 86.748 -27.150 1.818 1.00 38.91 ? 494 GLN C CG 1 ATOM 4566 C CD . GLN C 1 170 ? 85.383 -26.910 1.150 1.00 41.42 ? 494 GLN C CD 1 ATOM 4567 O OE1 . GLN C 1 170 ? 84.382 -26.676 1.834 1.00 45.30 ? 494 GLN C OE1 1 ATOM 4568 N NE2 . GLN C 1 170 ? 85.339 -26.984 -0.186 1.00 42.59 ? 494 GLN C NE2 1 ATOM 4569 N N . PRO C 1 171 ? 87.049 -22.609 2.585 1.00 26.81 ? 495 PRO C N 1 ATOM 4570 C CA . PRO C 1 171 ? 87.322 -21.388 3.328 1.00 27.87 ? 495 PRO C CA 1 ATOM 4571 C C . PRO C 1 171 ? 87.983 -21.657 4.670 1.00 30.71 ? 495 PRO C C 1 ATOM 4572 O O . PRO C 1 171 ? 87.593 -22.573 5.386 1.00 31.37 ? 495 PRO C O 1 ATOM 4573 C CB . PRO C 1 171 ? 85.946 -20.777 3.501 1.00 26.88 ? 495 PRO C CB 1 ATOM 4574 C CG . PRO C 1 171 ? 85.128 -21.349 2.381 1.00 26.04 ? 495 PRO C CG 1 ATOM 4575 C CD . PRO C 1 171 ? 85.639 -22.714 2.172 1.00 26.05 ? 495 PRO C CD 1 ATOM 4576 N N . ARG C 1 172 ? 88.999 -20.863 4.987 1.00 34.34 ? 496 ARG C N 1 ATOM 4577 C CA . ARG C 1 172 ? 89.783 -21.018 6.205 1.00 36.35 ? 496 ARG C CA 1 ATOM 4578 C C . ARG C 1 172 ? 89.889 -19.632 6.824 1.00 36.34 ? 496 ARG C C 1 ATOM 4579 O O . ARG C 1 172 ? 89.828 -18.628 6.120 1.00 35.04 ? 496 ARG C O 1 ATOM 4580 C CB . ARG C 1 172 ? 91.196 -21.527 5.888 1.00 38.83 ? 496 ARG C CB 1 ATOM 4581 C CG . ARG C 1 172 ? 91.382 -23.051 5.778 1.00 42.40 ? 496 ARG C CG 1 ATOM 4582 C CD . ARG C 1 172 ? 92.791 -23.409 5.200 1.00 45.24 ? 496 ARG C CD 1 ATOM 4583 N NE . ARG C 1 172 ? 93.212 -24.798 5.444 1.00 48.18 ? 496 ARG C NE 1 ATOM 4584 C CZ . ARG C 1 172 ? 93.902 -25.221 6.510 1.00 49.66 ? 496 ARG C CZ 1 ATOM 4585 N NH1 . ARG C 1 172 ? 94.282 -24.374 7.465 1.00 50.20 ? 496 ARG C NH1 1 ATOM 4586 N NH2 . ARG C 1 172 ? 94.220 -26.508 6.626 1.00 49.87 ? 496 ARG C NH2 1 ATOM 4587 N N . LYS C 1 173 ? 90.071 -19.577 8.137 1.00 38.02 ? 497 LYS C N 1 ATOM 4588 C CA . LYS C 1 173 ? 90.157 -18.303 8.848 1.00 39.18 ? 497 LYS C CA 1 ATOM 4589 C C . LYS C 1 173 ? 91.451 -17.570 8.528 1.00 38.81 ? 497 LYS C C 1 ATOM 4590 O O . LYS C 1 173 ? 92.527 -18.174 8.516 1.00 39.60 ? 497 LYS C O 1 ATOM 4591 C CB . LYS C 1 173 ? 90.082 -18.537 10.356 1.00 41.03 ? 497 LYS C CB 1 ATOM 4592 C CG . LYS C 1 173 ? 88.675 -18.786 10.893 1.00 43.05 ? 497 LYS C CG 1 ATOM 4593 C CD . LYS C 1 173 ? 87.843 -17.509 10.924 1.00 44.40 ? 497 LYS C CD 1 ATOM 4594 C CE . LYS C 1 173 ? 86.583 -17.670 11.783 1.00 45.26 ? 497 LYS C CE 1 ATOM 4595 N NZ . LYS C 1 173 ? 85.745 -16.423 11.800 1.00 46.13 ? 497 LYS C NZ 1 ATOM 4596 N N . THR C 1 174 ? 91.340 -16.269 8.266 1.00 38.45 ? 498 THR C N 1 ATOM 4597 C CA . THR C 1 174 ? 92.502 -15.387 8.254 1.00 38.15 ? 498 THR C CA 1 ATOM 4598 C C . THR C 1 174 ? 92.827 -14.971 9.681 1.00 37.92 ? 498 THR C C 1 ATOM 4599 O O . THR C 1 174 ? 92.161 -15.364 10.635 1.00 36.44 ? 498 THR C O 1 ATOM 4600 C CB . THR C 1 174 ? 92.280 -14.095 7.455 1.00 37.83 ? 498 THR C CB 1 ATOM 4601 O OG1 . THR C 1 174 ? 91.384 -13.246 8.173 1.00 37.55 ? 498 THR C OG1 1 ATOM 4602 C CG2 . THR C 1 174 ? 91.719 -14.379 6.079 1.00 39.57 ? 498 THR C CG2 1 ATOM 4603 N N . LYS C 1 175 ? 93.864 -14.164 9.818 1.00 38.25 ? 499 LYS C N 1 ATOM 4604 C CA . LYS C 1 175 ? 94.283 -13.720 11.135 1.00 39.40 ? 499 LYS C CA 1 ATOM 4605 C C . LYS C 1 175 ? 93.207 -12.816 11.749 1.00 38.23 ? 499 LYS C C 1 ATOM 4606 O O . LYS C 1 175 ? 92.979 -12.824 12.948 1.00 35.64 ? 499 LYS C O 1 ATOM 4607 C CB . LYS C 1 175 ? 95.643 -13.033 11.022 1.00 40.18 ? 499 LYS C CB 1 ATOM 4608 C CG . LYS C 1 175 ? 96.743 -13.969 10.511 1.00 40.96 ? 499 LYS C CG 1 ATOM 4609 C CD . LYS C 1 175 ? 97.412 -14.732 11.636 1.00 41.91 ? 499 LYS C CD 1 ATOM 4610 C CE . LYS C 1 175 ? 98.361 -13.821 12.450 1.00 43.29 ? 499 LYS C CE 1 ATOM 4611 N NZ . LYS C 1 175 ? 99.484 -13.228 11.646 1.00 43.52 ? 499 LYS C NZ 1 ATOM 4612 N N . GLY C 1 176 ? 92.519 -12.053 10.910 1.00 38.96 ? 500 GLY C N 1 ATOM 4613 C CA . GLY C 1 176 ? 91.416 -11.220 11.388 1.00 38.79 ? 500 GLY C CA 1 ATOM 4614 C C . GLY C 1 176 ? 90.121 -12.004 11.508 1.00 38.12 ? 500 GLY C C 1 ATOM 4615 O O . GLY C 1 176 ? 90.071 -13.101 12.063 1.00 38.06 ? 500 GLY C O 1 ATOM 4616 N N . SER C 1 177 ? 89.050 -11.436 10.982 1.00 36.89 ? 501 SER C N 1 ATOM 4617 C CA . SER C 1 177 ? 87.749 -12.083 11.097 1.00 36.25 ? 501 SER C CA 1 ATOM 4618 C C . SER C 1 177 ? 87.354 -12.801 9.806 1.00 35.37 ? 501 SER C C 1 ATOM 4619 O O . SER C 1 177 ? 86.525 -13.724 9.829 1.00 37.24 ? 501 SER C O 1 ATOM 4620 C CB . SER C 1 177 ? 86.691 -11.041 11.452 1.00 36.50 ? 501 SER C CB 1 ATOM 4621 O OG . SER C 1 177 ? 86.656 -10.829 12.853 1.00 35.83 ? 501 SER C OG 1 ATOM 4622 N N . GLY C 1 178 ? 87.970 -12.377 8.701 1.00 31.32 ? 502 GLY C N 1 ATOM 4623 C CA . GLY C 1 178 ? 87.603 -12.828 7.380 1.00 29.32 ? 502 GLY C CA 1 ATOM 4624 C C . GLY C 1 178 ? 88.069 -14.231 7.081 1.00 28.30 ? 502 GLY C C 1 ATOM 4625 O O . GLY C 1 178 ? 88.679 -14.896 7.915 1.00 29.92 ? 502 GLY C O 1 ATOM 4626 N N . PHE C 1 179 ? 87.768 -14.681 5.873 1.00 27.13 ? 503 PHE C N 1 ATOM 4627 C CA . PHE C 1 179 ? 88.179 -16.001 5.414 1.00 25.45 ? 503 PHE C CA 1 ATOM 4628 C C . PHE C 1 179 ? 88.975 -15.851 4.121 1.00 24.59 ? 503 PHE C C 1 ATOM 4629 O O . PHE C 1 179 ? 88.958 -14.801 3.444 1.00 23.05 ? 503 PHE C O 1 ATOM 4630 C CB . PHE C 1 179 ? 86.968 -16.910 5.155 1.00 24.16 ? 503 PHE C CB 1 ATOM 4631 C CG . PHE C 1 179 ? 86.103 -17.173 6.369 1.00 24.65 ? 503 PHE C CG 1 ATOM 4632 C CD1 . PHE C 1 179 ? 85.076 -16.301 6.719 1.00 24.69 ? 503 PHE C CD1 1 ATOM 4633 C CD2 . PHE C 1 179 ? 86.281 -18.311 7.136 1.00 24.89 ? 503 PHE C CD2 1 ATOM 4634 C CE1 . PHE C 1 179 ? 84.271 -16.547 7.806 1.00 23.61 ? 503 PHE C CE1 1 ATOM 4635 C CE2 . PHE C 1 179 ? 85.470 -18.560 8.236 1.00 24.32 ? 503 PHE C CE2 1 ATOM 4636 C CZ . PHE C 1 179 ? 84.468 -17.669 8.564 1.00 23.52 ? 503 PHE C CZ 1 ATOM 4637 N N . PHE C 1 180 ? 89.675 -16.925 3.781 1.00 23.75 ? 504 PHE C N 1 ATOM 4638 C CA . PHE C 1 180 ? 90.438 -16.968 2.546 1.00 22.27 ? 504 PHE C CA 1 ATOM 4639 C C . PHE C 1 180 ? 90.346 -18.334 1.931 1.00 23.77 ? 504 PHE C C 1 ATOM 4640 O O . PHE C 1 180 ? 90.178 -19.330 2.636 1.00 24.92 ? 504 PHE C O 1 ATOM 4641 C CB . PHE C 1 180 ? 91.905 -16.654 2.778 1.00 19.73 ? 504 PHE C CB 1 ATOM 4642 C CG . PHE C 1 180 ? 92.684 -17.793 3.352 1.00 18.83 ? 504 PHE C CG 1 ATOM 4643 C CD1 . PHE C 1 180 ? 93.331 -18.693 2.528 1.00 19.82 ? 504 PHE C CD1 1 ATOM 4644 C CD2 . PHE C 1 180 ? 92.829 -17.934 4.720 1.00 20.26 ? 504 PHE C CD2 1 ATOM 4645 C CE1 . PHE C 1 180 ? 94.093 -19.742 3.051 1.00 19.31 ? 504 PHE C CE1 1 ATOM 4646 C CE2 . PHE C 1 180 ? 93.582 -18.967 5.264 1.00 19.48 ? 504 PHE C CE2 1 ATOM 4647 C CZ . PHE C 1 180 ? 94.220 -19.871 4.427 1.00 19.88 ? 504 PHE C CZ 1 ATOM 4648 N N . VAL C 1 181 ? 90.482 -18.338 0.607 1.00 24.15 ? 505 VAL C N 1 ATOM 4649 C CA . VAL C 1 181 ? 90.469 -19.530 -0.189 1.00 23.73 ? 505 VAL C CA 1 ATOM 4650 C C . VAL C 1 181 ? 91.501 -19.381 -1.301 1.00 22.84 ? 505 VAL C C 1 ATOM 4651 O O . VAL C 1 181 ? 91.844 -18.273 -1.715 1.00 21.82 ? 505 VAL C O 1 ATOM 4652 C CB . VAL C 1 181 ? 89.067 -19.752 -0.791 1.00 26.28 ? 505 VAL C CB 1 ATOM 4653 C CG1 . VAL C 1 181 ? 88.763 -18.723 -1.889 1.00 23.90 ? 505 VAL C CG1 1 ATOM 4654 C CG2 . VAL C 1 181 ? 89.000 -21.131 -1.351 1.00 29.59 ? 505 VAL C CG2 1 ATOM 4655 N N . PHE C 1 182 ? 92.020 -20.513 -1.757 1.00 23.68 ? 506 PHE C N 1 ATOM 4656 C CA . PHE C 1 182 ? 92.991 -20.552 -2.833 1.00 23.83 ? 506 PHE C CA 1 ATOM 4657 C C . PHE C 1 182 ? 92.385 -21.395 -3.933 1.00 23.35 ? 506 PHE C C 1 ATOM 4658 O O . PHE C 1 182 ? 91.736 -22.411 -3.652 1.00 23.28 ? 506 PHE C O 1 ATOM 4659 C CB . PHE C 1 182 ? 94.249 -21.298 -2.399 1.00 25.03 ? 506 PHE C CB 1 ATOM 4660 C CG . PHE C 1 182 ? 95.281 -20.454 -1.687 1.00 24.97 ? 506 PHE C CG 1 ATOM 4661 C CD1 . PHE C 1 182 ? 95.521 -20.640 -0.333 1.00 24.59 ? 506 PHE C CD1 1 ATOM 4662 C CD2 . PHE C 1 182 ? 96.039 -19.529 -2.377 1.00 24.97 ? 506 PHE C CD2 1 ATOM 4663 C CE1 . PHE C 1 182 ? 96.474 -19.910 0.321 1.00 23.81 ? 506 PHE C CE1 1 ATOM 4664 C CE2 . PHE C 1 182 ? 97.004 -18.790 -1.730 1.00 25.53 ? 506 PHE C CE2 1 ATOM 4665 C CZ . PHE C 1 182 ? 97.217 -18.988 -0.373 1.00 25.56 ? 506 PHE C CZ 1 ATOM 4666 N N . SER C 1 183 ? 92.616 -20.981 -5.172 1.00 21.50 ? 507 SER C N 1 ATOM 4667 C CA . SER C 1 183 ? 92.159 -21.728 -6.323 1.00 19.69 ? 507 SER C CA 1 ATOM 4668 C C . SER C 1 183 ? 93.303 -21.902 -7.297 1.00 19.12 ? 507 SER C C 1 ATOM 4669 O O . SER C 1 183 ? 94.015 -20.937 -7.580 1.00 20.68 ? 507 SER C O 1 ATOM 4670 C CB . SER C 1 183 ? 91.039 -20.975 -7.020 1.00 21.47 ? 507 SER C CB 1 ATOM 4671 O OG . SER C 1 183 ? 90.313 -21.843 -7.875 1.00 24.19 ? 507 SER C OG 1 ATOM 4672 N N . ARG C 1 184 ? 93.445 -23.123 -7.816 1.00 17.61 ? 508 ARG C N 1 ATOM 4673 C CA . ARG C 1 184 ? 94.507 -23.508 -8.717 1.00 17.19 ? 508 ARG C CA 1 ATOM 4674 C C . ARG C 1 184 ? 93.974 -23.977 -10.086 1.00 18.25 ? 508 ARG C C 1 ATOM 4675 O O . ARG C 1 184 ? 93.000 -24.725 -10.183 1.00 17.96 ? 508 ARG C O 1 ATOM 4676 C CB . ARG C 1 184 ? 95.264 -24.635 -8.042 1.00 18.27 ? 508 ARG C CB 1 ATOM 4677 C CG . ARG C 1 184 ? 96.432 -25.196 -8.814 1.00 19.43 ? 508 ARG C CG 1 ATOM 4678 C CD . ARG C 1 184 ? 97.082 -26.301 -8.008 1.00 21.27 ? 508 ARG C CD 1 ATOM 4679 N NE . ARG C 1 184 ? 98.230 -26.860 -8.706 1.00 23.26 ? 508 ARG C NE 1 ATOM 4680 C CZ . ARG C 1 184 ? 98.169 -27.710 -9.723 1.00 23.61 ? 508 ARG C CZ 1 ATOM 4681 N NH1 . ARG C 1 184 ? 97.005 -28.148 -10.170 1.00 25.13 ? 508 ARG C NH1 1 ATOM 4682 N NH2 . ARG C 1 184 ? 99.289 -28.127 -10.291 1.00 23.70 ? 508 ARG C NH2 1 ATOM 4683 N N . LEU C 1 185 ? 94.605 -23.533 -11.164 1.00 18.63 ? 509 LEU C N 1 ATOM 4684 C CA . LEU C 1 185 ? 94.143 -23.903 -12.506 1.00 19.23 ? 509 LEU C CA 1 ATOM 4685 C C . LEU C 1 185 ? 95.330 -24.098 -13.412 1.00 18.12 ? 509 LEU C C 1 ATOM 4686 O O . LEU C 1 185 ? 95.997 -23.106 -13.722 1.00 19.94 ? 509 LEU C O 1 ATOM 4687 C CB . LEU C 1 185 ? 93.305 -22.787 -13.105 1.00 18.53 ? 509 LEU C CB 1 ATOM 4688 C CG . LEU C 1 185 ? 92.996 -23.012 -14.586 1.00 20.13 ? 509 LEU C CG 1 ATOM 4689 C CD1 . LEU C 1 185 ? 92.104 -24.251 -14.822 1.00 20.33 ? 509 LEU C CD1 1 ATOM 4690 C CD2 . LEU C 1 185 ? 92.405 -21.728 -15.217 1.00 17.14 ? 509 LEU C CD2 1 ATOM 4691 N N . GLU C 1 186 ? 95.605 -25.339 -13.794 1.00 14.27 ? 510 GLU C N 1 ATOM 4692 C CA . GLU C 1 186 ? 96.599 -25.625 -14.821 1.00 16.74 ? 510 GLU C CA 1 ATOM 4693 C C . GLU C 1 186 ? 96.078 -25.271 -16.203 1.00 17.44 ? 510 GLU C C 1 ATOM 4694 O O . GLU C 1 186 ? 94.992 -25.681 -16.567 1.00 15.90 ? 510 GLU C O 1 ATOM 4695 C CB . GLU C 1 186 ? 96.930 -27.107 -14.872 1.00 18.29 ? 510 GLU C CB 1 ATOM 4696 C CG . GLU C 1 186 ? 97.617 -27.616 -13.636 1.00 22.22 ? 510 GLU C CG 1 ATOM 4697 C CD . GLU C 1 186 ? 98.077 -29.053 -13.758 1.00 26.37 ? 510 GLU C CD 1 ATOM 4698 O OE1 . GLU C 1 186 ? 98.558 -29.459 -14.859 1.00 28.94 ? 510 GLU C OE1 1 ATOM 4699 O OE2 . GLU C 1 186 ? 97.939 -29.757 -12.725 1.00 29.48 ? 510 GLU C OE2 1 ATOM 4700 N N . VAL C 1 187 ? 96.872 -24.530 -16.965 1.00 18.71 ? 511 VAL C N 1 ATOM 4701 C CA . VAL C 1 187 ? 96.527 -24.176 -18.325 1.00 20.20 ? 511 VAL C CA 1 ATOM 4702 C C . VAL C 1 187 ? 97.543 -24.758 -19.297 1.00 19.67 ? 511 VAL C C 1 ATOM 4703 O O . VAL C 1 187 ? 98.691 -25.002 -18.938 1.00 21.15 ? 511 VAL C O 1 ATOM 4704 C CB . VAL C 1 187 ? 96.454 -22.626 -18.494 1.00 20.80 ? 511 VAL C CB 1 ATOM 4705 C CG1 . VAL C 1 187 ? 95.367 -22.035 -17.593 1.00 20.74 ? 511 VAL C CG1 1 ATOM 4706 C CG2 . VAL C 1 187 ? 97.792 -21.987 -18.195 1.00 19.14 ? 511 VAL C CG2 1 ATOM 4707 N N . THR C 1 188 ? 97.108 -24.979 -20.529 1.00 21.43 ? 512 THR C N 1 ATOM 4708 C CA . THR C 1 188 ? 97.983 -25.414 -21.620 1.00 22.35 ? 512 THR C CA 1 ATOM 4709 C C . THR C 1 188 ? 98.456 -24.299 -22.543 1.00 23.96 ? 512 THR C C 1 ATOM 4710 O O . THR C 1 188 ? 97.923 -23.182 -22.603 1.00 22.29 ? 512 THR C O 1 ATOM 4711 C CB . THR C 1 188 ? 97.255 -26.350 -22.555 1.00 22.97 ? 512 THR C CB 1 ATOM 4712 O OG1 . THR C 1 188 ? 96.276 -25.581 -23.259 1.00 20.56 ? 512 THR C OG1 1 ATOM 4713 C CG2 . THR C 1 188 ? 96.601 -27.543 -21.774 1.00 22.41 ? 512 THR C CG2 1 ATOM 4714 N N . ARG C 1 189 ? 99.486 -24.647 -23.287 1.00 26.73 ? 513 ARG C N 1 ATOM 4715 C CA . ARG C 1 189 ? 100.143 -23.716 -24.167 1.00 28.16 ? 513 ARG C CA 1 ATOM 4716 C C . ARG C 1 189 ? 99.164 -23.276 -25.245 1.00 27.46 ? 513 ARG C C 1 ATOM 4717 O O . ARG C 1 189 ? 99.210 -22.144 -25.720 1.00 28.75 ? 513 ARG C O 1 ATOM 4718 C CB . ARG C 1 189 ? 101.342 -24.409 -24.811 1.00 30.28 ? 513 ARG C CB 1 ATOM 4719 C CG . ARG C 1 189 ? 102.127 -23.505 -25.760 1.00 32.53 ? 513 ARG C CG 1 ATOM 4720 C CD . ARG C 1 189 ? 103.585 -23.948 -25.930 1.00 33.69 ? 513 ARG C CD 1 ATOM 4721 N NE . ARG C 1 189 ? 104.472 -22.786 -25.901 1.00 34.95 ? 513 ARG C NE 1 ATOM 4722 C CZ . ARG C 1 189 ? 105.421 -22.577 -24.997 1.00 36.03 ? 513 ARG C CZ 1 ATOM 4723 N NH1 . ARG C 1 189 ? 105.637 -23.451 -24.038 1.00 36.29 ? 513 ARG C NH1 1 ATOM 4724 N NH2 . ARG C 1 189 ? 106.172 -21.488 -25.057 1.00 37.77 ? 513 ARG C NH2 1 ATOM 4725 N N . ALA C 1 190 ? 98.279 -24.181 -25.638 1.00 26.43 ? 514 ALA C N 1 ATOM 4726 C CA . ALA C 1 190 ? 97.362 -23.909 -26.716 1.00 25.38 ? 514 ALA C CA 1 ATOM 4727 C C . ALA C 1 190 ? 96.447 -22.791 -26.273 1.00 24.22 ? 514 ALA C C 1 ATOM 4728 O O . ALA C 1 190 ? 96.130 -21.903 -27.042 1.00 27.00 ? 514 ALA C O 1 ATOM 4729 C CB . ALA C 1 190 ? 96.576 -25.154 -27.089 1.00 25.25 ? 514 ALA C CB 1 ATOM 4730 N N . GLU C 1 191 ? 96.034 -22.829 -25.019 1.00 24.48 ? 515 GLU C N 1 ATOM 4731 C CA . GLU C 1 191 ? 95.174 -21.800 -24.452 1.00 23.91 ? 515 GLU C CA 1 ATOM 4732 C C . GLU C 1 191 ? 95.834 -20.426 -24.337 1.00 23.42 ? 515 GLU C C 1 ATOM 4733 O O . GLU C 1 191 ? 95.227 -19.408 -24.677 1.00 23.10 ? 515 GLU C O 1 ATOM 4734 C CB . GLU C 1 191 ? 94.699 -22.261 -23.077 1.00 26.09 ? 515 GLU C CB 1 ATOM 4735 C CG . GLU C 1 191 ? 93.866 -23.530 -23.152 1.00 27.53 ? 515 GLU C CG 1 ATOM 4736 C CD . GLU C 1 191 ? 93.448 -24.078 -21.807 1.00 29.22 ? 515 GLU C CD 1 ATOM 4737 O OE1 . GLU C 1 191 ? 92.264 -24.433 -21.715 1.00 29.81 ? 515 GLU C OE1 1 ATOM 4738 O OE2 . GLU C 1 191 ? 94.260 -24.167 -20.855 1.00 32.17 ? 515 GLU C OE2 1 ATOM 4739 N N . TRP C 1 192 ? 97.066 -20.354 -23.850 1.00 22.49 ? 516 TRP C N 1 ATOM 4740 C CA . TRP C 1 192 ? 97.624 -19.029 -23.654 1.00 23.62 ? 516 TRP C CA 1 ATOM 4741 C C . TRP C 1 192 ? 98.201 -18.461 -24.941 1.00 22.41 ? 516 TRP C C 1 ATOM 4742 O O . TRP C 1 192 ? 98.430 -17.267 -25.057 1.00 22.07 ? 516 TRP C O 1 ATOM 4743 C CB . TRP C 1 192 ? 98.612 -18.972 -22.484 1.00 24.48 ? 516 TRP C CB 1 ATOM 4744 C CG . TRP C 1 192 ? 99.982 -19.475 -22.776 1.00 25.64 ? 516 TRP C CG 1 ATOM 4745 C CD1 . TRP C 1 192 ? 100.929 -18.895 -23.581 1.00 25.31 ? 516 TRP C CD1 1 ATOM 4746 C CD2 . TRP C 1 192 ? 100.590 -20.643 -22.213 1.00 26.23 ? 516 TRP C CD2 1 ATOM 4747 N NE1 . TRP C 1 192 ? 102.073 -19.650 -23.567 1.00 26.23 ? 516 TRP C NE1 1 ATOM 4748 C CE2 . TRP C 1 192 ? 101.890 -20.729 -22.739 1.00 26.58 ? 516 TRP C CE2 1 ATOM 4749 C CE3 . TRP C 1 192 ? 100.148 -21.632 -21.330 1.00 26.28 ? 516 TRP C CE3 1 ATOM 4750 C CZ2 . TRP C 1 192 ? 102.753 -21.769 -22.415 1.00 28.41 ? 516 TRP C CZ2 1 ATOM 4751 C CZ3 . TRP C 1 192 ? 101.001 -22.656 -21.003 1.00 28.41 ? 516 TRP C CZ3 1 ATOM 4752 C CH2 . TRP C 1 192 ? 102.296 -22.724 -21.544 1.00 28.90 ? 516 TRP C CH2 1 ATOM 4753 N N . GLU C 1 193 ? 98.409 -19.315 -25.930 1.00 23.70 ? 517 GLU C N 1 ATOM 4754 C CA . GLU C 1 193 ? 98.820 -18.837 -27.250 1.00 24.04 ? 517 GLU C CA 1 ATOM 4755 C C . GLU C 1 193 ? 97.656 -18.255 -28.054 1.00 22.61 ? 517 GLU C C 1 ATOM 4756 O O . GLU C 1 193 ? 97.819 -17.247 -28.750 1.00 20.64 ? 517 GLU C O 1 ATOM 4757 C CB . GLU C 1 193 ? 99.475 -19.968 -28.026 1.00 24.56 ? 517 GLU C CB 1 ATOM 4758 C CG . GLU C 1 193 ? 100.886 -20.261 -27.542 1.00 25.30 ? 517 GLU C CG 1 ATOM 4759 C CD . GLU C 1 193 ? 101.560 -21.353 -28.341 1.00 24.52 ? 517 GLU C CD 1 ATOM 4760 O OE1 . GLU C 1 193 ? 100.850 -22.126 -29.029 1.00 25.73 ? 517 GLU C OE1 1 ATOM 4761 O OE2 . GLU C 1 193 ? 102.800 -21.432 -28.263 1.00 23.70 ? 517 GLU C OE2 1 ATOM 4762 N N . GLN C 1 194 ? 96.500 -18.902 -27.940 1.00 21.90 ? 518 GLN C N 1 ATOM 4763 C CA . GLN C 1 194 ? 95.229 -18.343 -28.410 1.00 24.07 ? 518 GLN C CA 1 ATOM 4764 C C . GLN C 1 194 ? 94.859 -17.028 -27.729 1.00 22.45 ? 518 GLN C C 1 ATOM 4765 O O . GLN C 1 194 ? 94.602 -16.051 -28.393 1.00 20.70 ? 518 GLN C O 1 ATOM 4766 C CB . GLN C 1 194 ? 94.093 -19.360 -28.234 1.00 25.36 ? 518 GLN C CB 1 ATOM 4767 C CG . GLN C 1 194 ? 92.746 -18.909 -28.793 1.00 26.66 ? 518 GLN C CG 1 ATOM 4768 C CD . GLN C 1 194 ? 91.881 -18.217 -27.750 1.00 29.44 ? 518 GLN C CD 1 ATOM 4769 O OE1 . GLN C 1 194 ? 91.886 -18.585 -26.570 1.00 31.78 ? 518 GLN C OE1 1 ATOM 4770 N NE2 . GLN C 1 194 ? 91.140 -17.206 -28.173 1.00 30.22 ? 518 GLN C NE2 1 ATOM 4771 N N . LYS C 1 195 ? 94.824 -17.002 -26.406 1.00 24.78 ? 519 LYS C N 1 ATOM 4772 C CA . LYS C 1 195 ? 94.683 -15.739 -25.671 1.00 27.12 ? 519 LYS C CA 1 ATOM 4773 C C . LYS C 1 195 ? 95.331 -15.820 -24.295 1.00 26.39 ? 519 LYS C C 1 ATOM 4774 O O . LYS C 1 195 ? 94.920 -16.599 -23.453 1.00 26.20 ? 519 LYS C O 1 ATOM 4775 C CB . LYS C 1 195 ? 93.218 -15.391 -25.485 1.00 29.01 ? 519 LYS C CB 1 ATOM 4776 C CG . LYS C 1 195 ? 92.984 -14.044 -24.799 1.00 31.52 ? 519 LYS C CG 1 ATOM 4777 C CD . LYS C 1 195 ? 93.108 -12.892 -25.782 1.00 34.42 ? 519 LYS C CD 1 ATOM 4778 C CE . LYS C 1 195 ? 92.580 -11.549 -25.231 1.00 36.38 ? 519 LYS C CE 1 ATOM 4779 N NZ . LYS C 1 195 ? 91.095 -11.494 -25.054 1.00 36.85 ? 519 LYS C NZ 1 ATOM 4780 N N . ASP C 1 196 ? 96.348 -15.006 -24.075 1.00 26.09 ? 520 ASP C N 1 ATOM 4781 C CA . ASP C 1 196 ? 97.110 -15.058 -22.850 1.00 25.23 ? 520 ASP C CA 1 ATOM 4782 C C . ASP C 1 196 ? 96.498 -14.168 -21.773 1.00 25.22 ? 520 ASP C C 1 ATOM 4783 O O . ASP C 1 196 ? 97.105 -13.196 -21.289 1.00 23.80 ? 520 ASP C O 1 ATOM 4784 C CB . ASP C 1 196 ? 98.549 -14.636 -23.104 1.00 25.17 ? 520 ASP C CB 1 ATOM 4785 C CG . ASP C 1 196 ? 99.407 -14.891 -21.915 1.00 26.18 ? 520 ASP C CG 1 ATOM 4786 O OD1 . ASP C 1 196 ? 100.531 -14.369 -21.812 1.00 29.65 ? 520 ASP C OD1 1 ATOM 4787 O OD2 . ASP C 1 196 ? 98.920 -15.622 -21.048 1.00 28.40 ? 520 ASP C OD2 1 ATOM 4788 N N . GLU C 1 197 ? 95.278 -14.519 -21.393 1.00 25.35 ? 521 GLU C N 1 ATOM 4789 C CA . GLU C 1 197 ? 94.563 -13.770 -20.369 1.00 26.40 ? 521 GLU C CA 1 ATOM 4790 C C . GLU C 1 197 ? 93.554 -14.675 -19.726 1.00 22.42 ? 521 GLU C C 1 ATOM 4791 O O . GLU C 1 197 ? 92.661 -15.166 -20.393 1.00 19.95 ? 521 GLU C O 1 ATOM 4792 C CB . GLU C 1 197 ? 93.850 -12.555 -20.956 1.00 28.79 ? 521 GLU C CB 1 ATOM 4793 C CG . GLU C 1 197 ? 93.353 -11.658 -19.869 1.00 32.54 ? 521 GLU C CG 1 ATOM 4794 C CD . GLU C 1 197 ? 92.913 -10.329 -20.383 1.00 36.91 ? 521 GLU C CD 1 ATOM 4795 O OE1 . GLU C 1 197 ? 92.431 -10.268 -21.531 1.00 41.68 ? 521 GLU C OE1 1 ATOM 4796 O OE2 . GLU C 1 197 ? 93.051 -9.338 -19.638 1.00 41.25 ? 521 GLU C OE2 1 ATOM 4797 N N . PHE C 1 198 ? 93.720 -14.911 -18.430 1.00 20.76 ? 522 PHE C N 1 ATOM 4798 C CA . PHE C 1 198 ? 92.794 -15.755 -17.719 1.00 17.81 ? 522 PHE C CA 1 ATOM 4799 C C . PHE C 1 198 ? 92.171 -14.994 -16.549 1.00 17.73 ? 522 PHE C C 1 ATOM 4800 O O . PHE C 1 198 ? 92.848 -14.293 -15.815 1.00 19.58 ? 522 PHE C O 1 ATOM 4801 C CB . PHE C 1 198 ? 93.486 -17.017 -17.246 1.00 16.50 ? 522 PHE C CB 1 ATOM 4802 C CG . PHE C 1 198 ? 94.079 -17.822 -18.335 1.00 17.60 ? 522 PHE C CG 1 ATOM 4803 C CD1 . PHE C 1 198 ? 95.278 -17.464 -18.910 1.00 17.76 ? 522 PHE C CD1 1 ATOM 4804 C CD2 . PHE C 1 198 ? 93.452 -18.962 -18.779 1.00 19.52 ? 522 PHE C CD2 1 ATOM 4805 C CE1 . PHE C 1 198 ? 95.805 -18.205 -19.929 1.00 18.26 ? 522 PHE C CE1 1 ATOM 4806 C CE2 . PHE C 1 198 ? 93.991 -19.705 -19.811 1.00 18.10 ? 522 PHE C CE2 1 ATOM 4807 C CZ . PHE C 1 198 ? 95.163 -19.320 -20.381 1.00 18.43 ? 522 PHE C CZ 1 ATOM 4808 N N . ILE C 1 199 ? 90.874 -15.163 -16.372 1.00 17.77 ? 523 ILE C N 1 ATOM 4809 C CA . ILE C 1 199 ? 90.168 -14.494 -15.310 1.00 20.11 ? 523 ILE C CA 1 ATOM 4810 C C . ILE C 1 199 ? 89.832 -15.414 -14.142 1.00 20.69 ? 523 ILE C C 1 ATOM 4811 O O . ILE C 1 199 ? 89.269 -16.486 -14.325 1.00 22.83 ? 523 ILE C O 1 ATOM 4812 C CB . ILE C 1 199 ? 88.860 -13.885 -15.844 1.00 19.94 ? 523 ILE C CB 1 ATOM 4813 C CG1 . ILE C 1 199 ? 89.120 -13.060 -17.107 1.00 20.65 ? 523 ILE C CG1 1 ATOM 4814 C CG2 . ILE C 1 199 ? 88.241 -13.009 -14.775 1.00 21.80 ? 523 ILE C CG2 1 ATOM 4815 C CD1 . ILE C 1 199 ? 89.928 -11.821 -16.931 1.00 19.65 ? 523 ILE C CD1 1 ATOM 4816 N N . CYS C 1 200 ? 90.185 -14.988 -12.935 1.00 22.35 ? 524 CYS C N 1 ATOM 4817 C CA . CYS C 1 200 ? 89.720 -15.615 -11.702 1.00 20.70 ? 524 CYS C CA 1 ATOM 4818 C C . CYS C 1 200 ? 88.575 -14.764 -11.173 1.00 20.81 ? 524 CYS C C 1 ATOM 4819 O O . CYS C 1 200 ? 88.736 -13.562 -10.936 1.00 20.99 ? 524 CYS C O 1 ATOM 4820 C CB . CYS C 1 200 ? 90.850 -15.632 -10.671 1.00 21.91 ? 524 CYS C CB 1 ATOM 4821 S SG . CYS C 1 200 ? 90.357 -16.239 -9.030 1.00 24.55 ? 524 CYS C SG 1 ATOM 4822 N N . ARG C 1 201 ? 87.416 -15.384 -10.987 1.00 20.89 ? 525 ARG C N 1 ATOM 4823 C CA . ARG C 1 201 ? 86.208 -14.678 -10.587 1.00 20.63 ? 525 ARG C CA 1 ATOM 4824 C C . ARG C 1 201 ? 85.640 -15.245 -9.286 1.00 21.63 ? 525 ARG C C 1 ATOM 4825 O O . ARG C 1 201 ? 85.419 -16.439 -9.151 1.00 23.03 ? 525 ARG C O 1 ATOM 4826 C CB . ARG C 1 201 ? 85.153 -14.777 -11.683 1.00 20.80 ? 525 ARG C CB 1 ATOM 4827 C CG . ARG C 1 201 ? 83.857 -14.032 -11.409 1.00 23.04 ? 525 ARG C CG 1 ATOM 4828 C CD . ARG C 1 201 ? 83.453 -13.236 -12.620 1.00 25.73 ? 525 ARG C CD 1 ATOM 4829 N NE . ARG C 1 201 ? 82.599 -13.983 -13.522 1.00 28.55 ? 525 ARG C NE 1 ATOM 4830 C CZ . ARG C 1 201 ? 82.405 -13.677 -14.806 1.00 28.25 ? 525 ARG C CZ 1 ATOM 4831 N NH1 . ARG C 1 201 ? 83.007 -12.654 -15.384 1.00 26.61 ? 525 ARG C NH1 1 ATOM 4832 N NH2 . ARG C 1 201 ? 81.600 -14.429 -15.529 1.00 30.13 ? 525 ARG C NH2 1 ATOM 4833 N N . ALA C 1 202 ? 85.375 -14.344 -8.352 1.00 22.54 ? 526 ALA C N 1 ATOM 4834 C CA . ALA C 1 202 ? 84.816 -14.652 -7.059 1.00 22.33 ? 526 ALA C CA 1 ATOM 4835 C C . ALA C 1 202 ? 83.408 -14.057 -7.033 1.00 22.09 ? 526 ALA C C 1 ATOM 4836 O O . ALA C 1 202 ? 83.235 -12.847 -7.278 1.00 21.91 ? 526 ALA C O 1 ATOM 4837 C CB . ALA C 1 202 ? 85.688 -14.021 -5.965 1.00 21.70 ? 526 ALA C CB 1 ATOM 4838 N N . VAL C 1 203 ? 82.411 -14.898 -6.757 1.00 20.58 ? 527 VAL C N 1 ATOM 4839 C CA . VAL C 1 203 ? 81.055 -14.408 -6.485 1.00 19.39 ? 527 VAL C CA 1 ATOM 4840 C C . VAL C 1 203 ? 80.775 -14.437 -5.005 1.00 19.31 ? 527 VAL C C 1 ATOM 4841 O O . VAL C 1 203 ? 80.929 -15.467 -4.354 1.00 23.72 ? 527 VAL C O 1 ATOM 4842 C CB . VAL C 1 203 ? 79.958 -15.202 -7.191 1.00 17.82 ? 527 VAL C CB 1 ATOM 4843 C CG1 . VAL C 1 203 ? 78.628 -14.572 -6.899 1.00 17.03 ? 527 VAL C CG1 1 ATOM 4844 C CG2 . VAL C 1 203 ? 80.180 -15.230 -8.708 1.00 17.02 ? 527 VAL C CG2 1 ATOM 4845 N N . HIS C 1 204 ? 80.373 -13.297 -4.471 1.00 20.24 ? 528 HIS C N 1 ATOM 4846 C CA . HIS C 1 204 ? 80.210 -13.142 -3.027 1.00 21.09 ? 528 HIS C CA 1 ATOM 4847 C C . HIS C 1 204 ? 79.211 -12.033 -2.712 1.00 22.50 ? 528 HIS C C 1 ATOM 4848 O O . HIS C 1 204 ? 79.256 -10.961 -3.318 1.00 22.38 ? 528 HIS C O 1 ATOM 4849 C CB . HIS C 1 204 ? 81.537 -12.761 -2.365 1.00 20.16 ? 528 HIS C CB 1 ATOM 4850 C CG . HIS C 1 204 ? 81.484 -12.804 -0.878 1.00 19.55 ? 528 HIS C CG 1 ATOM 4851 N ND1 . HIS C 1 204 ? 80.981 -11.770 -0.122 1.00 20.94 ? 528 HIS C ND1 1 ATOM 4852 C CD2 . HIS C 1 204 ? 81.850 -13.770 -0.003 1.00 20.57 ? 528 HIS C CD2 1 ATOM 4853 C CE1 . HIS C 1 204 ? 81.046 -12.094 1.158 1.00 20.49 ? 528 HIS C CE1 1 ATOM 4854 N NE2 . HIS C 1 204 ? 81.566 -13.304 1.258 1.00 19.95 ? 528 HIS C NE2 1 ATOM 4855 N N . GLU C 1 205 ? 78.357 -12.298 -1.730 1.00 22.61 ? 529 GLU C N 1 ATOM 4856 C CA . GLU C 1 205 ? 77.334 -11.368 -1.295 1.00 24.31 ? 529 GLU C CA 1 ATOM 4857 C C . GLU C 1 205 ? 77.738 -9.897 -1.142 1.00 23.84 ? 529 GLU C C 1 ATOM 4858 O O . GLU C 1 205 ? 76.986 -9.012 -1.546 1.00 23.52 ? 529 GLU C O 1 ATOM 4859 C CB . GLU C 1 205 ? 76.756 -11.857 0.036 1.00 26.05 ? 529 GLU C CB 1 ATOM 4860 C CG . GLU C 1 205 ? 75.786 -10.861 0.648 1.00 27.81 ? 529 GLU C CG 1 ATOM 4861 C CD . GLU C 1 205 ? 75.256 -11.278 2.007 1.00 28.18 ? 529 GLU C CD 1 ATOM 4862 O OE1 . GLU C 1 205 ? 75.664 -12.348 2.507 1.00 28.83 ? 529 GLU C OE1 1 ATOM 4863 O OE2 . GLU C 1 205 ? 74.434 -10.517 2.557 1.00 28.26 ? 529 GLU C OE2 1 ATOM 4864 N N . ALA C 1 206 ? 78.895 -9.623 -0.551 1.00 24.40 ? 530 ALA C N 1 ATOM 4865 C CA . ALA C 1 206 ? 79.273 -8.246 -0.210 1.00 25.20 ? 530 ALA C CA 1 ATOM 4866 C C . ALA C 1 206 ? 80.211 -7.643 -1.274 1.00 27.24 ? 530 ALA C C 1 ATOM 4867 O O . ALA C 1 206 ? 80.717 -6.536 -1.126 1.00 27.35 ? 530 ALA C O 1 ATOM 4868 C CB . ALA C 1 206 ? 79.944 -8.226 1.160 1.00 25.04 ? 530 ALA C CB 1 ATOM 4869 N N . ALA C 1 207 ? 80.453 -8.387 -2.347 1.00 29.52 ? 531 ALA C N 1 ATOM 4870 C CA . ALA C 1 207 ? 81.128 -7.849 -3.520 1.00 31.88 ? 531 ALA C CA 1 ATOM 4871 C C . ALA C 1 207 ? 80.158 -6.949 -4.278 1.00 35.50 ? 531 ALA C C 1 ATOM 4872 O O . ALA C 1 207 ? 79.216 -7.424 -4.913 1.00 37.16 ? 531 ALA C O 1 ATOM 4873 C CB . ALA C 1 207 ? 81.601 -8.984 -4.429 1.00 29.71 ? 531 ALA C CB 1 ATOM 4874 N N . SER C 1 208 ? 80.364 -5.642 -4.210 1.00 38.81 ? 532 SER C N 1 ATOM 4875 C CA . SER C 1 208 ? 79.419 -4.745 -4.842 1.00 41.37 ? 532 SER C CA 1 ATOM 4876 C C . SER C 1 208 ? 79.970 -4.374 -6.203 1.00 41.43 ? 532 SER C C 1 ATOM 4877 O O . SER C 1 208 ? 81.170 -4.423 -6.403 1.00 39.96 ? 532 SER C O 1 ATOM 4878 C CB . SER C 1 208 ? 79.157 -3.504 -3.982 1.00 42.44 ? 532 SER C CB 1 ATOM 4879 O OG . SER C 1 208 ? 80.292 -2.670 -3.963 1.00 43.38 ? 532 SER C OG 1 ATOM 4880 N N . PRO C 1 209 ? 79.088 -4.025 -7.152 1.00 43.09 ? 533 PRO C N 1 ATOM 4881 C CA . PRO C 1 209 ? 77.627 -3.937 -7.047 1.00 43.99 ? 533 PRO C CA 1 ATOM 4882 C C . PRO C 1 209 ? 76.910 -5.181 -7.562 1.00 44.62 ? 533 PRO C C 1 ATOM 4883 O O . PRO C 1 209 ? 75.713 -5.338 -7.359 1.00 46.92 ? 533 PRO C O 1 ATOM 4884 C CB . PRO C 1 209 ? 77.310 -2.797 -8.007 1.00 43.92 ? 533 PRO C CB 1 ATOM 4885 C CG . PRO C 1 209 ? 78.326 -3.044 -9.149 1.00 43.28 ? 533 PRO C CG 1 ATOM 4886 C CD . PRO C 1 209 ? 79.559 -3.628 -8.494 1.00 43.46 ? 533 PRO C CD 1 ATOM 4887 N N . SER C 1 210 ? 77.649 -6.039 -8.245 1.00 44.24 ? 534 SER C N 1 ATOM 4888 C CA . SER C 1 210 ? 77.086 -7.107 -9.043 1.00 43.60 ? 534 SER C CA 1 ATOM 4889 C C . SER C 1 210 ? 77.358 -8.443 -8.341 1.00 40.44 ? 534 SER C C 1 ATOM 4890 O O . SER C 1 210 ? 77.199 -9.507 -8.936 1.00 39.11 ? 534 SER C O 1 ATOM 4891 C CB . SER C 1 210 ? 77.741 -7.072 -10.443 1.00 45.79 ? 534 SER C CB 1 ATOM 4892 O OG . SER C 1 210 ? 79.165 -6.861 -10.382 1.00 45.99 ? 534 SER C OG 1 ATOM 4893 N N . GLN C 1 211 ? 77.766 -8.373 -7.074 1.00 37.18 ? 535 GLN C N 1 ATOM 4894 C CA . GLN C 1 211 ? 78.161 -9.547 -6.287 1.00 34.98 ? 535 GLN C CA 1 ATOM 4895 C C . GLN C 1 211 ? 79.385 -10.271 -6.860 1.00 31.99 ? 535 GLN C C 1 ATOM 4896 O O . GLN C 1 211 ? 79.588 -11.455 -6.590 1.00 30.88 ? 535 GLN C O 1 ATOM 4897 C CB . GLN C 1 211 ? 77.014 -10.564 -6.153 1.00 35.96 ? 535 GLN C CB 1 ATOM 4898 C CG . GLN C 1 211 ? 75.601 -10.006 -6.271 1.00 37.57 ? 535 GLN C CG 1 ATOM 4899 C CD . GLN C 1 211 ? 75.324 -9.055 -5.183 1.00 37.27 ? 535 GLN C CD 1 ATOM 4900 O OE1 . GLN C 1 211 ? 74.783 -7.987 -5.408 1.00 36.93 ? 535 GLN C OE1 1 ATOM 4901 N NE2 . GLN C 1 211 ? 75.722 -9.426 -3.978 1.00 40.36 ? 535 GLN C NE2 1 ATOM 4902 N N . THR C 1 212 ? 80.204 -9.568 -7.636 1.00 30.71 ? 536 THR C N 1 ATOM 4903 C CA . THR C 1 212 ? 81.311 -10.180 -8.382 1.00 29.36 ? 536 THR C CA 1 ATOM 4904 C C . THR C 1 212 ? 82.569 -9.338 -8.274 1.00 27.88 ? 536 THR C C 1 ATOM 4905 O O . THR C 1 212 ? 82.518 -8.124 -8.324 1.00 28.33 ? 536 THR C O 1 ATOM 4906 C CB . THR C 1 212 ? 80.944 -10.324 -9.877 1.00 30.52 ? 536 THR C CB 1 ATOM 4907 O OG1 . THR C 1 212 ? 79.763 -11.121 -9.997 1.00 33.59 ? 536 THR C OG1 1 ATOM 4908 C CG2 . THR C 1 212 ? 82.031 -11.007 -10.671 1.00 30.92 ? 536 THR C CG2 1 ATOM 4909 N N . VAL C 1 213 ? 83.716 -9.975 -8.110 1.00 27.48 ? 537 VAL C N 1 ATOM 4910 C CA . VAL C 1 213 ? 84.987 -9.292 -8.315 1.00 25.45 ? 537 VAL C CA 1 ATOM 4911 C C . VAL C 1 213 ? 85.925 -10.263 -9.002 1.00 24.13 ? 537 VAL C C 1 ATOM 4912 O O . VAL C 1 213 ? 85.910 -11.482 -8.728 1.00 24.65 ? 537 VAL C O 1 ATOM 4913 C CB . VAL C 1 213 ? 85.618 -8.849 -6.981 1.00 27.55 ? 537 VAL C CB 1 ATOM 4914 C CG1 . VAL C 1 213 ? 86.921 -8.057 -7.209 1.00 27.27 ? 537 VAL C CG1 1 ATOM 4915 C CG2 . VAL C 1 213 ? 84.645 -7.984 -6.201 1.00 29.33 ? 537 VAL C CG2 1 ATOM 4916 N N . GLN C 1 214 ? 86.753 -9.746 -9.897 1.00 21.75 ? 538 GLN C N 1 ATOM 4917 C CA . GLN C 1 214 ? 87.612 -10.626 -10.672 1.00 21.04 ? 538 GLN C CA 1 ATOM 4918 C C . GLN C 1 214 ? 88.968 -10.015 -10.936 1.00 20.49 ? 538 GLN C C 1 ATOM 4919 O O . GLN C 1 214 ? 89.122 -8.796 -10.890 1.00 20.77 ? 538 GLN C O 1 ATOM 4920 C CB . GLN C 1 214 ? 86.940 -10.982 -11.997 1.00 21.08 ? 538 GLN C CB 1 ATOM 4921 C CG . GLN C 1 214 ? 86.798 -9.834 -12.954 1.00 20.52 ? 538 GLN C CG 1 ATOM 4922 C CD . GLN C 1 214 ? 85.990 -10.226 -14.180 1.00 21.60 ? 538 GLN C CD 1 ATOM 4923 O OE1 . GLN C 1 214 ? 84.841 -10.633 -14.060 1.00 22.48 ? 538 GLN C OE1 1 ATOM 4924 N NE2 . GLN C 1 214 ? 86.578 -10.105 -15.361 1.00 22.57 ? 538 GLN C NE2 1 ATOM 4925 N N . ARG C 1 215 ? 89.943 -10.875 -11.210 1.00 19.01 ? 539 ARG C N 1 ATOM 4926 C CA . ARG C 1 215 ? 91.266 -10.439 -11.634 1.00 19.80 ? 539 ARG C CA 1 ATOM 4927 C C . ARG C 1 215 ? 91.764 -11.219 -12.841 1.00 19.20 ? 539 ARG C C 1 ATOM 4928 O O . ARG C 1 215 ? 91.557 -12.426 -12.936 1.00 15.31 ? 539 ARG C O 1 ATOM 4929 C CB . ARG C 1 215 ? 92.281 -10.608 -10.512 1.00 21.79 ? 539 ARG C CB 1 ATOM 4930 C CG . ARG C 1 215 ? 92.201 -9.494 -9.494 1.00 25.49 ? 539 ARG C CG 1 ATOM 4931 C CD . ARG C 1 215 ? 92.981 -8.274 -9.963 1.00 27.88 ? 539 ARG C CD 1 ATOM 4932 N NE . ARG C 1 215 ? 93.004 -7.177 -8.989 1.00 29.30 ? 539 ARG C NE 1 ATOM 4933 C CZ . ARG C 1 215 ? 91.959 -6.409 -8.676 1.00 32.08 ? 539 ARG C CZ 1 ATOM 4934 N NH1 . ARG C 1 215 ? 90.755 -6.592 -9.229 1.00 31.56 ? 539 ARG C NH1 1 ATOM 4935 N NH2 . ARG C 1 215 ? 92.123 -5.426 -7.791 1.00 34.30 ? 539 ARG C NH2 1 ATOM 4936 N N . ALA C 1 216 ? 92.388 -10.489 -13.760 1.00 17.88 ? 540 ALA C N 1 ATOM 4937 C CA . ALA C 1 216 ? 93.037 -11.058 -14.922 1.00 19.38 ? 540 ALA C CA 1 ATOM 4938 C C . ALA C 1 216 ? 94.469 -11.399 -14.594 1.00 19.46 ? 540 ALA C C 1 ATOM 4939 O O . ALA C 1 216 ? 95.099 -10.729 -13.768 1.00 20.67 ? 540 ALA C O 1 ATOM 4940 C CB . ALA C 1 216 ? 93.028 -10.047 -16.062 1.00 17.13 ? 540 ALA C CB 1 ATOM 4941 N N . VAL C 1 217 ? 94.985 -12.423 -15.266 1.00 18.46 ? 541 VAL C N 1 ATOM 4942 C CA . VAL C 1 217 ? 96.390 -12.782 -15.144 1.00 18.41 ? 541 VAL C CA 1 ATOM 4943 C C . VAL C 1 217 ? 96.899 -13.344 -16.470 1.00 21.23 ? 541 VAL C C 1 ATOM 4944 O O . VAL C 1 217 ? 96.188 -14.097 -17.160 1.00 19.29 ? 541 VAL C O 1 ATOM 4945 C CB . VAL C 1 217 ? 96.609 -13.858 -14.064 1.00 18.69 ? 541 VAL C CB 1 ATOM 4946 C CG1 . VAL C 1 217 ? 95.835 -15.068 -14.365 1.00 17.57 ? 541 VAL C CG1 1 ATOM 4947 C CG2 . VAL C 1 217 ? 98.104 -14.223 -13.929 1.00 19.53 ? 541 VAL C CG2 1 ATOM 4948 N N . SER C 1 218 ? 98.127 -12.964 -16.813 1.00 23.05 ? 542 SER C N 1 ATOM 4949 C CA . SER C 1 218 ? 98.793 -13.481 -17.993 1.00 25.00 ? 542 SER C CA 1 ATOM 4950 C C . SER C 1 218 ? 99.948 -14.414 -17.642 1.00 27.58 ? 542 SER C C 1 ATOM 4951 O O . SER C 1 218 ? 100.662 -14.214 -16.650 1.00 26.40 ? 542 SER C O 1 ATOM 4952 C CB . SER C 1 218 ? 99.352 -12.322 -18.787 1.00 24.92 ? 542 SER C CB 1 ATOM 4953 O OG . SER C 1 218 ? 98.310 -11.573 -19.353 1.00 27.82 ? 542 SER C OG 1 ATOM 4954 N N . VAL C 1 219 ? 100.129 -15.428 -18.478 1.00 30.21 ? 543 VAL C N 1 ATOM 4955 C CA . VAL C 1 219 ? 101.253 -16.340 -18.340 1.00 32.59 ? 543 VAL C CA 1 ATOM 4956 C C . VAL C 1 219 ? 102.549 -15.600 -18.633 1.00 34.68 ? 543 VAL C C 1 ATOM 4957 O O . VAL C 1 219 ? 103.488 -15.706 -17.847 1.00 34.67 ? 543 VAL C O 1 ATOM 4958 C CB . VAL C 1 219 ? 101.082 -17.561 -19.250 1.00 32.92 ? 543 VAL C CB 1 ATOM 4959 C CG1 . VAL C 1 219 ? 102.376 -18.305 -19.384 1.00 34.85 ? 543 VAL C CG1 1 ATOM 4960 C CG2 . VAL C 1 219 ? 100.026 -18.463 -18.686 1.00 31.66 ? 543 VAL C CG2 1 ATOM 4961 N N . ASN C 1 220 ? 102.588 -14.831 -19.723 1.00 37.33 ? 544 ASN C N 1 ATOM 4962 C CA . ASN C 1 220 ? 103.733 -13.957 -20.034 1.00 40.44 ? 544 ASN C CA 1 ATOM 4963 C C . ASN C 1 220 ? 103.502 -12.457 -19.831 1.00 42.34 ? 544 ASN C C 1 ATOM 4964 O O . ASN C 1 220 ? 103.908 -11.821 -18.856 1.00 44.20 ? 544 ASN C O 1 ATOM 4965 C CB . ASN C 1 220 ? 104.158 -14.164 -21.487 1.00 42.08 ? 544 ASN C CB 1 ATOM 4966 C CG . ASN C 1 220 ? 104.590 -15.588 -21.770 1.00 43.90 ? 544 ASN C CG 1 ATOM 4967 O OD1 . ASN C 1 220 ? 105.059 -16.304 -20.877 1.00 44.86 ? 544 ASN C OD1 1 ATOM 4968 N ND2 . ASN C 1 220 ? 104.443 -16.006 -23.022 1.00 45.29 ? 544 ASN C ND2 1 ATOM 4969 N N . VAL D 1 12 ? 82.543 -41.706 16.190 1.00 46.32 ? 336 VAL D N 1 ATOM 4970 C CA . VAL D 1 12 ? 83.979 -41.814 16.595 1.00 47.23 ? 336 VAL D CA 1 ATOM 4971 C C . VAL D 1 12 ? 84.888 -42.180 15.418 1.00 47.90 ? 336 VAL D C 1 ATOM 4972 O O . VAL D 1 12 ? 84.797 -43.276 14.863 1.00 48.60 ? 336 VAL D O 1 ATOM 4973 C CB . VAL D 1 12 ? 84.182 -42.878 17.689 1.00 46.56 ? 336 VAL D CB 1 ATOM 4974 C CG1 . VAL D 1 12 ? 85.634 -42.916 18.116 1.00 45.61 ? 336 VAL D CG1 1 ATOM 4975 C CG2 . VAL D 1 12 ? 83.280 -42.599 18.873 1.00 46.79 ? 336 VAL D CG2 1 ATOM 4976 N N . SER D 1 13 ? 85.766 -41.261 15.030 1.00 47.91 ? 337 SER D N 1 ATOM 4977 C CA . SER D 1 13 ? 86.757 -41.558 13.993 1.00 48.14 ? 337 SER D CA 1 ATOM 4978 C C . SER D 1 13 ? 88.203 -41.549 14.534 1.00 47.39 ? 337 SER D C 1 ATOM 4979 O O . SER D 1 13 ? 88.483 -41.041 15.618 1.00 47.32 ? 337 SER D O 1 ATOM 4980 C CB . SER D 1 13 ? 86.575 -40.648 12.758 1.00 48.41 ? 337 SER D CB 1 ATOM 4981 O OG . SER D 1 13 ? 86.680 -39.259 13.033 1.00 48.13 ? 337 SER D OG 1 ATOM 4982 N N . ALA D 1 14 ? 89.119 -42.147 13.785 1.00 47.27 ? 338 ALA D N 1 ATOM 4983 C CA . ALA D 1 14 ? 90.508 -42.237 14.212 1.00 46.60 ? 338 ALA D CA 1 ATOM 4984 C C . ALA D 1 14 ? 91.431 -41.925 13.037 1.00 46.06 ? 338 ALA D C 1 ATOM 4985 O O . ALA D 1 14 ? 91.116 -42.232 11.889 1.00 44.82 ? 338 ALA D O 1 ATOM 4986 C CB . ALA D 1 14 ? 90.794 -43.613 14.763 1.00 46.22 ? 338 ALA D CB 1 ATOM 4987 N N . TYR D 1 15 ? 92.572 -41.305 13.330 1.00 45.68 ? 339 TYR D N 1 ATOM 4988 C CA . TYR D 1 15 ? 93.553 -40.971 12.305 1.00 43.87 ? 339 TYR D CA 1 ATOM 4989 C C . TYR D 1 15 ? 94.935 -41.270 12.869 1.00 42.65 ? 339 TYR D C 1 ATOM 4990 O O . TYR D 1 15 ? 95.227 -40.940 14.019 1.00 43.07 ? 339 TYR D O 1 ATOM 4991 C CB . TYR D 1 15 ? 93.435 -39.492 11.919 1.00 45.33 ? 339 TYR D CB 1 ATOM 4992 C CG . TYR D 1 15 ? 92.059 -39.060 11.430 1.00 46.60 ? 339 TYR D CG 1 ATOM 4993 C CD1 . TYR D 1 15 ? 91.126 -38.517 12.294 1.00 47.22 ? 339 TYR D CD1 1 ATOM 4994 C CD2 . TYR D 1 15 ? 91.701 -39.202 10.096 1.00 47.98 ? 339 TYR D CD2 1 ATOM 4995 C CE1 . TYR D 1 15 ? 89.877 -38.124 11.839 1.00 48.75 ? 339 TYR D CE1 1 ATOM 4996 C CE2 . TYR D 1 15 ? 90.464 -38.820 9.634 1.00 48.48 ? 339 TYR D CE2 1 ATOM 4997 C CZ . TYR D 1 15 ? 89.553 -38.281 10.505 1.00 49.45 ? 339 TYR D CZ 1 ATOM 4998 O OH . TYR D 1 15 ? 88.312 -37.909 10.028 1.00 50.93 ? 339 TYR D OH 1 ATOM 4999 N N . LEU D 1 16 ? 95.779 -41.904 12.066 1.00 40.29 ? 340 LEU D N 1 ATOM 5000 C CA . LEU D 1 16 ? 97.168 -42.121 12.423 1.00 38.42 ? 340 LEU D CA 1 ATOM 5001 C C . LEU D 1 16 ? 98.045 -41.506 11.333 1.00 38.28 ? 340 LEU D C 1 ATOM 5002 O O . LEU D 1 16 ? 97.965 -41.906 10.170 1.00 38.26 ? 340 LEU D O 1 ATOM 5003 C CB . LEU D 1 16 ? 97.430 -43.618 12.549 1.00 37.69 ? 340 LEU D CB 1 ATOM 5004 C CG . LEU D 1 16 ? 98.856 -44.060 12.851 1.00 37.51 ? 340 LEU D CG 1 ATOM 5005 C CD1 . LEU D 1 16 ? 99.353 -43.439 14.125 1.00 36.65 ? 340 LEU D CD1 1 ATOM 5006 C CD2 . LEU D 1 16 ? 98.923 -45.570 12.955 1.00 38.29 ? 340 LEU D CD2 1 ATOM 5007 N N . SER D 1 17 ? 98.871 -40.534 11.707 1.00 36.87 ? 341 SER D N 1 ATOM 5008 C CA . SER D 1 17 ? 99.631 -39.741 10.750 1.00 37.25 ? 341 SER D CA 1 ATOM 5009 C C . SER D 1 17 ? 101.102 -40.142 10.688 1.00 37.29 ? 341 SER D C 1 ATOM 5010 O O . SER D 1 17 ? 101.651 -40.701 11.639 1.00 38.37 ? 341 SER D O 1 ATOM 5011 C CB . SER D 1 17 ? 99.559 -38.269 11.145 1.00 38.68 ? 341 SER D CB 1 ATOM 5012 O OG . SER D 1 17 ? 100.314 -38.054 12.327 1.00 40.63 ? 341 SER D OG 1 ATOM 5013 N N . ARG D 1 18 ? 101.749 -39.856 9.565 1.00 34.70 ? 342 ARG D N 1 ATOM 5014 C CA . ARG D 1 18 ? 103.139 -40.226 9.410 1.00 33.51 ? 342 ARG D CA 1 ATOM 5015 C C . ARG D 1 18 ? 103.984 -39.125 10.027 1.00 31.42 ? 342 ARG D C 1 ATOM 5016 O O . ARG D 1 18 ? 103.501 -38.058 10.351 1.00 33.83 ? 342 ARG D O 1 ATOM 5017 C CB . ARG D 1 18 ? 103.502 -40.433 7.934 1.00 33.78 ? 342 ARG D CB 1 ATOM 5018 C CG . ARG D 1 18 ? 102.896 -41.678 7.300 1.00 35.79 ? 342 ARG D CG 1 ATOM 5019 C CD . ARG D 1 18 ? 103.193 -41.752 5.813 1.00 37.25 ? 342 ARG D CD 1 ATOM 5020 N NE . ARG D 1 18 ? 102.478 -40.686 5.112 1.00 39.43 ? 342 ARG D NE 1 ATOM 5021 C CZ . ARG D 1 18 ? 101.230 -40.788 4.657 1.00 40.39 ? 342 ARG D CZ 1 ATOM 5022 N NH1 . ARG D 1 18 ? 100.549 -41.915 4.797 1.00 40.11 ? 342 ARG D NH1 1 ATOM 5023 N NH2 . ARG D 1 18 ? 100.654 -39.753 4.052 1.00 40.99 ? 342 ARG D NH2 1 ATOM 5024 N N . PRO D 1 19 ? 105.272 -39.369 10.183 1.00 29.15 ? 343 PRO D N 1 ATOM 5025 C CA . PRO D 1 19 ? 106.123 -38.309 10.676 1.00 28.67 ? 343 PRO D CA 1 ATOM 5026 C C . PRO D 1 19 ? 106.178 -37.089 9.772 1.00 27.79 ? 343 PRO D C 1 ATOM 5027 O O . PRO D 1 19 ? 106.141 -37.182 8.574 1.00 29.95 ? 343 PRO D O 1 ATOM 5028 C CB . PRO D 1 19 ? 107.494 -38.975 10.735 1.00 28.76 ? 343 PRO D CB 1 ATOM 5029 C CG . PRO D 1 19 ? 107.191 -40.455 10.814 1.00 29.73 ? 343 PRO D CG 1 ATOM 5030 C CD . PRO D 1 19 ? 106.031 -40.589 9.882 1.00 30.02 ? 343 PRO D CD 1 ATOM 5031 N N . SER D 1 20 ? 106.292 -35.913 10.331 1.00 27.01 ? 344 SER D N 1 ATOM 5032 C CA . SER D 1 20 ? 106.481 -34.784 9.465 1.00 27.27 ? 344 SER D CA 1 ATOM 5033 C C . SER D 1 20 ? 107.897 -34.819 8.849 1.00 25.94 ? 344 SER D C 1 ATOM 5034 O O . SER D 1 20 ? 108.880 -35.129 9.523 1.00 26.43 ? 344 SER D O 1 ATOM 5035 C CB . SER D 1 20 ? 106.259 -33.510 10.287 1.00 26.86 ? 344 SER D CB 1 ATOM 5036 O OG . SER D 1 20 ? 107.467 -33.108 10.884 1.00 25.82 ? 344 SER D OG 1 ATOM 5037 N N . PRO D 1 21 ? 108.005 -34.505 7.557 1.00 23.77 ? 345 PRO D N 1 ATOM 5038 C CA . PRO D 1 21 ? 109.305 -34.547 6.920 1.00 23.64 ? 345 PRO D CA 1 ATOM 5039 C C . PRO D 1 21 ? 110.313 -33.754 7.699 1.00 23.79 ? 345 PRO D C 1 ATOM 5040 O O . PRO D 1 21 ? 111.449 -34.167 7.855 1.00 23.52 ? 345 PRO D O 1 ATOM 5041 C CB . PRO D 1 21 ? 109.038 -33.918 5.563 1.00 22.60 ? 345 PRO D CB 1 ATOM 5042 C CG . PRO D 1 21 ? 107.633 -34.344 5.241 1.00 22.16 ? 345 PRO D CG 1 ATOM 5043 C CD . PRO D 1 21 ? 106.920 -34.390 6.571 1.00 23.53 ? 345 PRO D CD 1 ATOM 5044 N N . PHE D 1 22 ? 109.872 -32.620 8.209 1.00 26.00 ? 346 PHE D N 1 ATOM 5045 C CA . PHE D 1 22 ? 110.744 -31.778 8.987 1.00 26.56 ? 346 PHE D CA 1 ATOM 5046 C C . PHE D 1 22 ? 111.303 -32.572 10.165 1.00 26.39 ? 346 PHE D C 1 ATOM 5047 O O . PHE D 1 22 ? 112.512 -32.616 10.346 1.00 27.25 ? 346 PHE D O 1 ATOM 5048 C CB . PHE D 1 22 ? 109.994 -30.525 9.446 1.00 26.77 ? 346 PHE D CB 1 ATOM 5049 C CG . PHE D 1 22 ? 110.782 -29.665 10.367 1.00 27.55 ? 346 PHE D CG 1 ATOM 5050 C CD1 . PHE D 1 22 ? 112.003 -29.144 9.971 1.00 29.40 ? 346 PHE D CD1 1 ATOM 5051 C CD2 . PHE D 1 22 ? 110.310 -29.369 11.629 1.00 28.18 ? 346 PHE D CD2 1 ATOM 5052 C CE1 . PHE D 1 22 ? 112.741 -28.353 10.819 1.00 29.09 ? 346 PHE D CE1 1 ATOM 5053 C CE2 . PHE D 1 22 ? 111.035 -28.566 12.491 1.00 27.93 ? 346 PHE D CE2 1 ATOM 5054 C CZ . PHE D 1 22 ? 112.251 -28.065 12.085 1.00 29.60 ? 346 PHE D CZ 1 ATOM 5055 N N . ASP D 1 23 ? 110.440 -33.189 10.969 1.00 27.84 ? 347 ASP D N 1 ATOM 5056 C CA . ASP D 1 23 ? 110.906 -33.922 12.151 1.00 27.97 ? 347 ASP D CA 1 ATOM 5057 C C . ASP D 1 23 ? 111.753 -35.118 11.726 1.00 28.25 ? 347 ASP D C 1 ATOM 5058 O O . ASP D 1 23 ? 112.718 -35.478 12.400 1.00 26.87 ? 347 ASP D O 1 ATOM 5059 C CB . ASP D 1 23 ? 109.755 -34.434 13.004 1.00 27.94 ? 347 ASP D CB 1 ATOM 5060 C CG . ASP D 1 23 ? 108.992 -33.332 13.694 1.00 29.03 ? 347 ASP D CG 1 ATOM 5061 O OD1 . ASP D 1 23 ? 107.800 -33.578 14.007 1.00 28.33 ? 347 ASP D OD1 1 ATOM 5062 O OD2 . ASP D 1 23 ? 109.561 -32.238 13.939 1.00 29.79 ? 347 ASP D OD2 1 ATOM 5063 N N . LEU D 1 24 ? 111.394 -35.730 10.601 1.00 28.06 ? 348 LEU D N 1 ATOM 5064 C CA . LEU D 1 24 ? 112.143 -36.879 10.112 1.00 28.74 ? 348 LEU D CA 1 ATOM 5065 C C . LEU D 1 24 ? 113.564 -36.571 9.602 1.00 30.15 ? 348 LEU D C 1 ATOM 5066 O O . LEU D 1 24 ? 114.529 -37.167 10.095 1.00 30.50 ? 348 LEU D O 1 ATOM 5067 C CB . LEU D 1 24 ? 111.337 -37.562 9.038 1.00 28.85 ? 348 LEU D CB 1 ATOM 5068 C CG . LEU D 1 24 ? 111.837 -38.912 8.539 1.00 29.54 ? 348 LEU D CG 1 ATOM 5069 C CD1 . LEU D 1 24 ? 112.128 -39.898 9.670 1.00 28.07 ? 348 LEU D CD1 1 ATOM 5070 C CD2 . LEU D 1 24 ? 110.766 -39.433 7.574 1.00 27.91 ? 348 LEU D CD2 1 ATOM 5071 N N . PHE D 1 25 ? 113.699 -35.635 8.654 1.00 29.40 ? 349 PHE D N 1 ATOM 5072 C CA . PHE D 1 25 ? 114.963 -35.410 7.943 1.00 28.67 ? 349 PHE D CA 1 ATOM 5073 C C . PHE D 1 25 ? 115.848 -34.321 8.546 1.00 29.95 ? 349 PHE D C 1 ATOM 5074 O O . PHE D 1 25 ? 117.071 -34.409 8.476 1.00 29.96 ? 349 PHE D O 1 ATOM 5075 C CB . PHE D 1 25 ? 114.706 -35.067 6.469 1.00 27.68 ? 349 PHE D CB 1 ATOM 5076 C CG . PHE D 1 25 ? 113.903 -36.101 5.754 1.00 27.65 ? 349 PHE D CG 1 ATOM 5077 C CD1 . PHE D 1 25 ? 112.615 -35.828 5.332 1.00 26.86 ? 349 PHE D CD1 1 ATOM 5078 C CD2 . PHE D 1 25 ? 114.422 -37.369 5.536 1.00 27.67 ? 349 PHE D CD2 1 ATOM 5079 C CE1 . PHE D 1 25 ? 111.857 -36.790 4.684 1.00 26.13 ? 349 PHE D CE1 1 ATOM 5080 C CE2 . PHE D 1 25 ? 113.675 -38.346 4.890 1.00 27.42 ? 349 PHE D CE2 1 ATOM 5081 C CZ . PHE D 1 25 ? 112.382 -38.053 4.460 1.00 27.19 ? 349 PHE D CZ 1 ATOM 5082 N N . ILE D 1 26 ? 115.257 -33.281 9.115 1.00 30.22 ? 350 ILE D N 1 ATOM 5083 C CA . ILE D 1 26 ? 116.066 -32.230 9.703 1.00 32.46 ? 350 ILE D CA 1 ATOM 5084 C C . ILE D 1 26 ? 116.300 -32.429 11.210 1.00 34.66 ? 350 ILE D C 1 ATOM 5085 O O . ILE D 1 26 ? 117.434 -32.490 11.692 1.00 34.94 ? 350 ILE D O 1 ATOM 5086 C CB . ILE D 1 26 ? 115.434 -30.847 9.475 1.00 32.06 ? 350 ILE D CB 1 ATOM 5087 C CG1 . ILE D 1 26 ? 115.092 -30.652 7.992 1.00 32.00 ? 350 ILE D CG1 1 ATOM 5088 C CG2 . ILE D 1 26 ? 116.394 -29.753 9.974 1.00 31.05 ? 350 ILE D CG2 1 ATOM 5089 C CD1 . ILE D 1 26 ? 116.226 -31.010 7.040 1.00 31.89 ? 350 ILE D CD1 1 ATOM 5090 N N . ARG D 1 27 ? 115.209 -32.522 11.952 1.00 36.29 ? 351 ARG D N 1 ATOM 5091 C CA . ARG D 1 27 ? 115.261 -32.554 13.395 1.00 38.00 ? 351 ARG D CA 1 ATOM 5092 C C . ARG D 1 27 ? 115.737 -33.941 13.855 1.00 37.98 ? 351 ARG D C 1 ATOM 5093 O O . ARG D 1 27 ? 116.258 -34.088 14.957 1.00 38.41 ? 351 ARG D O 1 ATOM 5094 C CB . ARG D 1 27 ? 113.859 -32.234 13.908 1.00 40.15 ? 351 ARG D CB 1 ATOM 5095 C CG . ARG D 1 27 ? 113.775 -31.544 15.241 1.00 42.91 ? 351 ARG D CG 1 ATOM 5096 C CD . ARG D 1 27 ? 112.334 -31.149 15.565 1.00 44.56 ? 351 ARG D CD 1 ATOM 5097 N NE . ARG D 1 27 ? 112.175 -30.942 16.996 1.00 46.64 ? 351 ARG D NE 1 ATOM 5098 C CZ . ARG D 1 27 ? 111.817 -31.873 17.882 1.00 49.28 ? 351 ARG D CZ 1 ATOM 5099 N NH1 . ARG D 1 27 ? 111.542 -33.116 17.506 1.00 49.91 ? 351 ARG D NH1 1 ATOM 5100 N NH2 . ARG D 1 27 ? 111.714 -31.554 19.173 1.00 50.63 ? 351 ARG D NH2 1 ATOM 5101 N N . LYS D 1 28 ? 115.563 -34.952 13.009 1.00 38.46 ? 352 LYS D N 1 ATOM 5102 C CA . LYS D 1 28 ? 116.020 -36.307 13.301 1.00 39.13 ? 352 LYS D CA 1 ATOM 5103 C C . LYS D 1 28 ? 115.326 -36.864 14.537 1.00 39.22 ? 352 LYS D C 1 ATOM 5104 O O . LYS D 1 28 ? 115.927 -37.637 15.297 1.00 40.30 ? 352 LYS D O 1 ATOM 5105 C CB . LYS D 1 28 ? 117.536 -36.337 13.532 1.00 41.10 ? 352 LYS D CB 1 ATOM 5106 C CG . LYS D 1 28 ? 118.398 -35.875 12.358 1.00 42.13 ? 352 LYS D CG 1 ATOM 5107 C CD . LYS D 1 28 ? 118.487 -36.956 11.299 1.00 43.41 ? 352 LYS D CD 1 ATOM 5108 C CE . LYS D 1 28 ? 119.460 -36.565 10.186 1.00 44.74 ? 352 LYS D CE 1 ATOM 5109 N NZ . LYS D 1 28 ? 119.391 -37.549 9.064 1.00 45.60 ? 352 LYS D NZ 1 ATOM 5110 N N . SER D 1 29 ? 114.068 -36.479 14.750 1.00 36.77 ? 353 SER D N 1 ATOM 5111 C CA . SER D 1 29 ? 113.254 -37.130 15.776 1.00 34.89 ? 353 SER D CA 1 ATOM 5112 C C . SER D 1 29 ? 111.815 -37.211 15.345 1.00 32.22 ? 353 SER D C 1 ATOM 5113 O O . SER D 1 29 ? 110.988 -36.394 15.728 1.00 29.68 ? 353 SER D O 1 ATOM 5114 C CB . SER D 1 29 ? 113.352 -36.438 17.133 1.00 34.58 ? 353 SER D CB 1 ATOM 5115 O OG . SER D 1 29 ? 113.598 -35.069 16.938 1.00 38.11 ? 353 SER D OG 1 ATOM 5116 N N . PRO D 1 30 ? 111.509 -38.231 14.545 1.00 31.73 ? 354 PRO D N 1 ATOM 5117 C CA . PRO D 1 30 ? 110.163 -38.478 14.012 1.00 30.61 ? 354 PRO D CA 1 ATOM 5118 C C . PRO D 1 30 ? 109.211 -38.937 15.102 1.00 28.68 ? 354 PRO D C 1 ATOM 5119 O O . PRO D 1 30 ? 109.636 -39.606 16.030 1.00 28.04 ? 354 PRO D O 1 ATOM 5120 C CB . PRO D 1 30 ? 110.362 -39.622 13.018 1.00 30.37 ? 354 PRO D CB 1 ATOM 5121 C CG . PRO D 1 30 ? 111.797 -39.960 13.024 1.00 31.84 ? 354 PRO D CG 1 ATOM 5122 C CD . PRO D 1 30 ? 112.472 -39.273 14.173 1.00 32.23 ? 354 PRO D CD 1 ATOM 5123 N N . THR D 1 31 ? 107.937 -38.601 14.969 1.00 27.19 ? 355 THR D N 1 ATOM 5124 C CA . THR D 1 31 ? 106.895 -39.102 15.859 1.00 26.56 ? 355 THR D CA 1 ATOM 5125 C C . THR D 1 31 ? 105.675 -39.370 14.998 1.00 26.58 ? 355 THR D C 1 ATOM 5126 O O . THR D 1 31 ? 105.534 -38.758 13.929 1.00 24.95 ? 355 THR D O 1 ATOM 5127 C CB . THR D 1 31 ? 106.482 -38.050 16.873 1.00 26.56 ? 355 THR D CB 1 ATOM 5128 O OG1 . THR D 1 31 ? 106.026 -36.898 16.161 1.00 29.21 ? 355 THR D OG1 1 ATOM 5129 C CG2 . THR D 1 31 ? 107.661 -37.660 17.768 1.00 24.33 ? 355 THR D CG2 1 ATOM 5130 N N . ILE D 1 32 ? 104.804 -40.277 15.435 1.00 24.80 ? 356 ILE D N 1 ATOM 5131 C CA . ILE D 1 32 ? 103.548 -40.467 14.733 1.00 24.26 ? 356 ILE D CA 1 ATOM 5132 C C . ILE D 1 32 ? 102.482 -40.192 15.746 1.00 25.36 ? 356 ILE D C 1 ATOM 5133 O O . ILE D 1 32 ? 102.742 -40.316 16.939 1.00 26.49 ? 356 ILE D O 1 ATOM 5134 C CB . ILE D 1 32 ? 103.368 -41.887 14.192 1.00 24.84 ? 356 ILE D CB 1 ATOM 5135 C CG1 . ILE D 1 32 ? 103.493 -42.940 15.300 1.00 24.42 ? 356 ILE D CG1 1 ATOM 5136 C CG2 . ILE D 1 32 ? 104.339 -42.147 13.056 1.00 24.62 ? 356 ILE D CG2 1 ATOM 5137 C CD1 . ILE D 1 32 ? 103.715 -44.371 14.751 1.00 24.12 ? 356 ILE D CD1 1 ATOM 5138 N N . THR D 1 33 ? 101.306 -39.795 15.281 1.00 27.12 ? 357 THR D N 1 ATOM 5139 C CA . THR D 1 33 ? 100.253 -39.366 16.179 1.00 30.84 ? 357 THR D CA 1 ATOM 5140 C C . THR D 1 33 ? 98.947 -40.059 15.867 1.00 32.09 ? 357 THR D C 1 ATOM 5141 O O . THR D 1 33 ? 98.492 -40.072 14.735 1.00 31.33 ? 357 THR D O 1 ATOM 5142 C CB . THR D 1 33 ? 100.044 -37.837 16.118 1.00 33.03 ? 357 THR D CB 1 ATOM 5143 O OG1 . THR D 1 33 ? 101.258 -37.182 16.527 1.00 34.46 ? 357 THR D OG1 1 ATOM 5144 C CG2 . THR D 1 33 ? 98.923 -37.430 17.046 1.00 32.16 ? 357 THR D CG2 1 ATOM 5145 N N . CYS D 1 34 ? 98.361 -40.652 16.893 1.00 34.36 ? 358 CYS D N 1 ATOM 5146 C CA . CYS D 1 34 ? 97.081 -41.309 16.773 1.00 35.98 ? 358 CYS D CA 1 ATOM 5147 C C . CYS D 1 34 ? 96.075 -40.323 17.329 1.00 36.95 ? 358 CYS D C 1 ATOM 5148 O O . CYS D 1 34 ? 96.113 -39.987 18.512 1.00 33.36 ? 358 CYS D O 1 ATOM 5149 C CB . CYS D 1 34 ? 97.082 -42.598 17.592 1.00 38.31 ? 358 CYS D CB 1 ATOM 5150 S SG . CYS D 1 34 ? 95.738 -43.723 17.232 1.00 39.73 ? 358 CYS D SG 1 ATOM 5151 N N . LEU D 1 35 ? 95.199 -39.849 16.449 1.00 38.39 ? 359 LEU D N 1 ATOM 5152 C CA . LEU D 1 35 ? 94.185 -38.887 16.817 1.00 40.00 ? 359 LEU D CA 1 ATOM 5153 C C . LEU D 1 35 ? 92.820 -39.567 16.852 1.00 40.98 ? 359 LEU D C 1 ATOM 5154 O O . LEU D 1 35 ? 92.358 -40.154 15.869 1.00 41.97 ? 359 LEU D O 1 ATOM 5155 C CB . LEU D 1 35 ? 94.202 -37.724 15.822 1.00 40.60 ? 359 LEU D CB 1 ATOM 5156 C CG . LEU D 1 35 ? 93.001 -36.778 15.818 1.00 41.47 ? 359 LEU D CG 1 ATOM 5157 C CD1 . LEU D 1 35 ? 92.783 -36.128 17.190 1.00 40.63 ? 359 LEU D CD1 1 ATOM 5158 C CD2 . LEU D 1 35 ? 93.192 -35.704 14.739 1.00 41.57 ? 359 LEU D CD2 1 ATOM 5159 N N . VAL D 1 36 ? 92.176 -39.489 18.007 1.00 42.32 ? 360 VAL D N 1 ATOM 5160 C CA . VAL D 1 36 ? 90.832 -40.028 18.177 1.00 42.58 ? 360 VAL D CA 1 ATOM 5161 C C . VAL D 1 36 ? 89.841 -38.904 18.477 1.00 43.52 ? 360 VAL D C 1 ATOM 5162 O O . VAL D 1 36 ? 90.030 -38.140 19.418 1.00 40.65 ? 360 VAL D O 1 ATOM 5163 C CB . VAL D 1 36 ? 90.801 -41.064 19.306 1.00 42.05 ? 360 VAL D CB 1 ATOM 5164 C CG1 . VAL D 1 36 ? 89.403 -41.623 19.483 1.00 41.14 ? 360 VAL D CG1 1 ATOM 5165 C CG2 . VAL D 1 36 ? 91.809 -42.169 19.026 1.00 41.14 ? 360 VAL D CG2 1 ATOM 5166 N N . VAL D 1 37 ? 88.802 -38.820 17.648 1.00 46.49 ? 361 VAL D N 1 ATOM 5167 C CA . VAL D 1 37 ? 87.736 -37.829 17.781 1.00 49.79 ? 361 VAL D CA 1 ATOM 5168 C C . VAL D 1 37 ? 86.423 -38.530 18.145 1.00 52.07 ? 361 VAL D C 1 ATOM 5169 O O . VAL D 1 37 ? 85.918 -39.353 17.387 1.00 51.57 ? 361 VAL D O 1 ATOM 5170 C CB . VAL D 1 37 ? 87.533 -37.034 16.459 1.00 50.28 ? 361 VAL D CB 1 ATOM 5171 C CG1 . VAL D 1 37 ? 86.419 -35.989 16.601 1.00 50.61 ? 361 VAL D CG1 1 ATOM 5172 C CG2 . VAL D 1 37 ? 88.831 -36.371 16.022 1.00 50.16 ? 361 VAL D CG2 1 ATOM 5173 N N . ASP D 1 38 ? 85.884 -38.200 19.314 1.00 55.66 ? 362 ASP D N 1 ATOM 5174 C CA . ASP D 1 38 ? 84.666 -38.820 19.829 1.00 57.92 ? 362 ASP D CA 1 ATOM 5175 C C . ASP D 1 38 ? 83.541 -37.788 19.816 1.00 59.26 ? 362 ASP D C 1 ATOM 5176 O O . ASP D 1 38 ? 83.541 -36.860 20.624 1.00 60.06 ? 362 ASP D O 1 ATOM 5177 C CB . ASP D 1 38 ? 84.911 -39.335 21.253 1.00 58.28 ? 362 ASP D CB 1 ATOM 5178 C CG . ASP D 1 38 ? 83.689 -40.002 21.853 1.00 58.86 ? 362 ASP D CG 1 ATOM 5179 O OD1 . ASP D 1 38 ? 82.688 -40.156 21.126 1.00 59.20 ? 362 ASP D OD1 1 ATOM 5180 O OD2 . ASP D 1 38 ? 83.726 -40.371 23.047 1.00 59.28 ? 362 ASP D OD2 1 ATOM 5181 N N . LEU D 1 39 ? 82.584 -37.942 18.904 1.00 61.06 ? 363 LEU D N 1 ATOM 5182 C CA . LEU D 1 39 ? 81.518 -36.941 18.751 1.00 62.95 ? 363 LEU D CA 1 ATOM 5183 C C . LEU D 1 39 ? 80.576 -36.817 19.966 1.00 64.02 ? 363 LEU D C 1 ATOM 5184 O O . LEU D 1 39 ? 79.997 -35.754 20.197 1.00 64.71 ? 363 LEU D O 1 ATOM 5185 C CB . LEU D 1 39 ? 80.706 -37.189 17.471 1.00 62.83 ? 363 LEU D CB 1 ATOM 5186 C CG . LEU D 1 39 ? 81.420 -37.109 16.114 1.00 62.75 ? 363 LEU D CG 1 ATOM 5187 C CD1 . LEU D 1 39 ? 80.377 -36.971 14.999 1.00 62.31 ? 363 LEU D CD1 1 ATOM 5188 C CD2 . LEU D 1 39 ? 82.425 -35.963 16.049 1.00 62.09 ? 363 LEU D CD2 1 ATOM 5189 N N . ALA D 1 40 ? 80.419 -37.886 20.742 1.00 65.20 ? 364 ALA D N 1 ATOM 5190 C CA . ALA D 1 40 ? 79.644 -37.827 21.982 1.00 66.05 ? 364 ALA D CA 1 ATOM 5191 C C . ALA D 1 40 ? 80.443 -38.433 23.141 1.00 67.36 ? 364 ALA D C 1 ATOM 5192 O O . ALA D 1 40 ? 80.521 -39.653 23.281 1.00 67.61 ? 364 ALA D O 1 ATOM 5193 C CB . ALA D 1 40 ? 78.312 -38.547 21.807 1.00 66.22 ? 364 ALA D CB 1 ATOM 5194 N N . PRO D 1 41 ? 81.041 -37.575 23.983 1.00 69.00 ? 365 PRO D N 1 ATOM 5195 C CA . PRO D 1 41 ? 81.918 -38.019 25.065 1.00 69.38 ? 365 PRO D CA 1 ATOM 5196 C C . PRO D 1 41 ? 81.158 -38.771 26.149 1.00 69.89 ? 365 PRO D C 1 ATOM 5197 O O . PRO D 1 41 ? 80.081 -38.334 26.561 1.00 69.78 ? 365 PRO D O 1 ATOM 5198 C CB . PRO D 1 41 ? 82.463 -36.710 25.656 1.00 69.56 ? 365 PRO D CB 1 ATOM 5199 C CG . PRO D 1 41 ? 81.913 -35.589 24.831 1.00 69.53 ? 365 PRO D CG 1 ATOM 5200 C CD . PRO D 1 41 ? 80.764 -36.130 24.050 1.00 69.59 ? 365 PRO D CD 1 ATOM 5201 N N . SER D 1 42 ? 81.723 -39.881 26.614 1.00 70.39 ? 366 SER D N 1 ATOM 5202 C CA . SER D 1 42 ? 81.174 -40.599 27.762 1.00 70.85 ? 366 SER D CA 1 ATOM 5203 C C . SER D 1 42 ? 82.098 -40.462 28.974 1.00 71.16 ? 366 SER D C 1 ATOM 5204 O O . SER D 1 42 ? 83.153 -39.827 28.892 1.00 70.57 ? 366 SER D O 1 ATOM 5205 C CB . SER D 1 42 ? 80.963 -42.074 27.411 1.00 71.15 ? 366 SER D CB 1 ATOM 5206 O OG . SER D 1 42 ? 82.153 -42.654 26.900 1.00 71.62 ? 366 SER D OG 1 ATOM 5207 N N . LYS D 1 43 ? 81.696 -41.044 30.102 1.00 71.61 ? 367 LYS D N 1 ATOM 5208 C CA . LYS D 1 43 ? 82.550 -41.079 31.288 1.00 71.80 ? 367 LYS D CA 1 ATOM 5209 C C . LYS D 1 43 ? 83.348 -42.384 31.331 1.00 70.70 ? 367 LYS D C 1 ATOM 5210 O O . LYS D 1 43 ? 82.912 -43.385 31.900 1.00 70.24 ? 367 LYS D O 1 ATOM 5211 C CB . LYS D 1 43 ? 81.718 -40.894 32.564 1.00 72.59 ? 367 LYS D CB 1 ATOM 5212 C CG . LYS D 1 43 ? 81.116 -39.495 32.726 1.00 73.24 ? 367 LYS D CG 1 ATOM 5213 C CD . LYS D 1 43 ? 82.204 -38.420 32.736 1.00 73.61 ? 367 LYS D CD 1 ATOM 5214 C CE . LYS D 1 43 ? 81.634 -37.009 32.707 1.00 73.69 ? 367 LYS D CE 1 ATOM 5215 N NZ . LYS D 1 43 ? 82.600 -36.088 32.031 1.00 73.45 ? 367 LYS D NZ 1 ATOM 5216 N N . GLY D 1 44 ? 84.522 -42.358 30.709 1.00 69.49 ? 368 GLY D N 1 ATOM 5217 C CA . GLY D 1 44 ? 85.408 -43.518 30.659 1.00 68.56 ? 368 GLY D CA 1 ATOM 5218 C C . GLY D 1 44 ? 86.589 -43.226 29.755 1.00 67.54 ? 368 GLY D C 1 ATOM 5219 O O . GLY D 1 44 ? 86.423 -42.595 28.713 1.00 67.59 ? 368 GLY D O 1 ATOM 5220 N N . THR D 1 45 ? 87.780 -43.675 30.148 1.00 66.42 ? 369 THR D N 1 ATOM 5221 C CA . THR D 1 45 ? 89.011 -43.340 29.421 1.00 65.65 ? 369 THR D CA 1 ATOM 5222 C C . THR D 1 45 ? 89.272 -44.242 28.209 1.00 63.76 ? 369 THR D C 1 ATOM 5223 O O . THR D 1 45 ? 89.426 -45.460 28.330 1.00 63.35 ? 369 THR D O 1 ATOM 5224 C CB . THR D 1 45 ? 90.254 -43.361 30.348 1.00 66.45 ? 369 THR D CB 1 ATOM 5225 O OG1 . THR D 1 45 ? 90.402 -44.661 30.933 1.00 67.29 ? 369 THR D OG1 1 ATOM 5226 C CG2 . THR D 1 45 ? 90.119 -42.317 31.463 1.00 67.00 ? 369 THR D CG2 1 ATOM 5227 N N . VAL D 1 46 ? 89.324 -43.616 27.038 1.00 61.65 ? 370 VAL D N 1 ATOM 5228 C CA . VAL D 1 46 ? 89.642 -44.294 25.788 1.00 59.98 ? 370 VAL D CA 1 ATOM 5229 C C . VAL D 1 46 ? 91.117 -44.673 25.778 1.00 58.29 ? 370 VAL D C 1 ATOM 5230 O O . VAL D 1 46 ? 91.962 -43.781 25.790 1.00 59.64 ? 370 VAL D O 1 ATOM 5231 C CB . VAL D 1 46 ? 89.423 -43.335 24.593 1.00 60.05 ? 370 VAL D CB 1 ATOM 5232 C CG1 . VAL D 1 46 ? 89.732 -44.042 23.282 1.00 60.05 ? 370 VAL D CG1 1 ATOM 5233 C CG2 . VAL D 1 46 ? 88.004 -42.750 24.597 1.00 59.91 ? 370 VAL D CG2 1 ATOM 5234 N N . GLN D 1 47 ? 91.456 -45.963 25.758 1.00 55.60 ? 371 GLN D N 1 ATOM 5235 C CA . GLN D 1 47 ? 92.877 -46.342 25.804 1.00 53.50 ? 371 GLN D CA 1 ATOM 5236 C C . GLN D 1 47 ? 93.497 -46.409 24.396 1.00 50.36 ? 371 GLN D C 1 ATOM 5237 O O . GLN D 1 47 ? 92.870 -46.905 23.460 1.00 48.62 ? 371 GLN D O 1 ATOM 5238 C CB . GLN D 1 47 ? 93.082 -47.642 26.595 1.00 54.34 ? 371 GLN D CB 1 ATOM 5239 C CG . GLN D 1 47 ? 92.779 -47.525 28.107 1.00 55.52 ? 371 GLN D CG 1 ATOM 5240 C CD . GLN D 1 47 ? 93.931 -46.943 28.943 1.00 56.42 ? 371 GLN D CD 1 ATOM 5241 O OE1 . GLN D 1 47 ? 93.890 -46.957 30.179 1.00 56.29 ? 371 GLN D OE1 1 ATOM 5242 N NE2 . GLN D 1 47 ? 94.963 -46.438 28.269 1.00 57.20 ? 371 GLN D NE2 1 ATOM 5243 N N . LEU D 1 48 ? 94.706 -45.869 24.239 1.00 47.35 ? 372 LEU D N 1 ATOM 5244 C CA . LEU D 1 48 ? 95.413 -45.913 22.958 1.00 45.25 ? 372 LEU D CA 1 ATOM 5245 C C . LEU D 1 48 ? 96.703 -46.662 23.173 1.00 43.29 ? 372 LEU D C 1 ATOM 5246 O O . LEU D 1 48 ? 97.554 -46.225 23.937 1.00 42.99 ? 372 LEU D O 1 ATOM 5247 C CB . LEU D 1 48 ? 95.751 -44.523 22.412 1.00 45.04 ? 372 LEU D CB 1 ATOM 5248 C CG . LEU D 1 48 ? 94.610 -43.569 22.038 1.00 45.33 ? 372 LEU D CG 1 ATOM 5249 C CD1 . LEU D 1 48 ? 95.062 -42.406 21.160 1.00 44.22 ? 372 LEU D CD1 1 ATOM 5250 C CD2 . LEU D 1 48 ? 93.526 -44.319 21.323 1.00 46.98 ? 372 LEU D CD2 1 ATOM 5251 N N . THR D 1 49 ? 96.833 -47.795 22.494 1.00 41.76 ? 373 THR D N 1 ATOM 5252 C CA . THR D 1 49 ? 97.944 -48.707 22.708 1.00 39.43 ? 373 THR D CA 1 ATOM 5253 C C . THR D 1 49 ? 98.770 -48.763 21.454 1.00 36.76 ? 373 THR D C 1 ATOM 5254 O O . THR D 1 49 ? 98.249 -48.846 20.343 1.00 37.87 ? 373 THR D O 1 ATOM 5255 C CB . THR D 1 49 ? 97.446 -50.119 23.022 1.00 40.28 ? 373 THR D CB 1 ATOM 5256 O OG1 . THR D 1 49 ? 96.799 -50.087 24.294 1.00 41.93 ? 373 THR D OG1 1 ATOM 5257 C CG2 . THR D 1 49 ? 98.595 -51.144 23.052 1.00 41.26 ? 373 THR D CG2 1 ATOM 5258 N N . TRP D 1 50 ? 100.077 -48.717 21.629 1.00 33.67 ? 374 TRP D N 1 ATOM 5259 C CA . TRP D 1 50 ? 100.954 -48.766 20.487 1.00 31.55 ? 374 TRP D CA 1 ATOM 5260 C C . TRP D 1 50 ? 101.661 -50.107 20.398 1.00 28.54 ? 374 TRP D C 1 ATOM 5261 O O . TRP D 1 50 ? 101.997 -50.696 21.412 1.00 27.73 ? 374 TRP D O 1 ATOM 5262 C CB . TRP D 1 50 ? 102.010 -47.692 20.613 1.00 30.81 ? 374 TRP D CB 1 ATOM 5263 C CG . TRP D 1 50 ? 101.526 -46.342 20.499 1.00 31.35 ? 374 TRP D CG 1 ATOM 5264 C CD1 . TRP D 1 50 ? 101.280 -45.479 21.510 1.00 31.99 ? 374 TRP D CD1 1 ATOM 5265 C CD2 . TRP D 1 50 ? 101.269 -45.638 19.288 1.00 33.26 ? 374 TRP D CD2 1 ATOM 5266 N NE1 . TRP D 1 50 ? 100.879 -44.265 21.007 1.00 32.84 ? 374 TRP D NE1 1 ATOM 5267 C CE2 . TRP D 1 50 ? 100.861 -44.337 19.642 1.00 32.05 ? 374 TRP D CE2 1 ATOM 5268 C CE3 . TRP D 1 50 ? 101.341 -45.984 17.933 1.00 33.17 ? 374 TRP D CE3 1 ATOM 5269 C CZ2 . TRP D 1 50 ? 100.515 -43.385 18.700 1.00 32.34 ? 374 TRP D CZ2 1 ATOM 5270 C CZ3 . TRP D 1 50 ? 101.007 -45.045 17.003 1.00 32.79 ? 374 TRP D CZ3 1 ATOM 5271 C CH2 . TRP D 1 50 ? 100.591 -43.756 17.387 1.00 33.33 ? 374 TRP D CH2 1 ATOM 5272 N N . SER D 1 51 ? 101.893 -50.558 19.169 1.00 26.75 ? 375 SER D N 1 ATOM 5273 C CA . SER D 1 51 ? 102.791 -51.686 18.910 1.00 26.79 ? 375 SER D CA 1 ATOM 5274 C C . SER D 1 51 ? 103.397 -51.615 17.522 1.00 25.23 ? 375 SER D C 1 ATOM 5275 O O . SER D 1 51 ? 102.947 -50.855 16.676 1.00 23.75 ? 375 SER D O 1 ATOM 5276 C CB . SER D 1 51 ? 102.011 -52.979 18.991 1.00 26.08 ? 375 SER D CB 1 ATOM 5277 O OG . SER D 1 51 ? 100.918 -52.837 18.115 1.00 26.50 ? 375 SER D OG 1 ATOM 5278 N N . ARG D 1 52 ? 104.407 -52.440 17.284 1.00 25.15 ? 376 ARG D N 1 ATOM 5279 C CA . ARG D 1 52 ? 104.931 -52.623 15.939 1.00 23.66 ? 376 ARG D CA 1 ATOM 5280 C C . ARG D 1 52 ? 104.473 -53.938 15.323 1.00 23.37 ? 376 ARG D C 1 ATOM 5281 O O . ARG D 1 52 ? 104.324 -54.952 16.015 1.00 22.84 ? 376 ARG D O 1 ATOM 5282 C CB . ARG D 1 52 ? 106.443 -52.654 16.002 1.00 24.78 ? 376 ARG D CB 1 ATOM 5283 C CG . ARG D 1 52 ? 107.086 -51.460 16.704 1.00 24.50 ? 376 ARG D CG 1 ATOM 5284 C CD . ARG D 1 52 ? 108.418 -51.279 16.038 1.00 24.34 ? 376 ARG D CD 1 ATOM 5285 N NE . ARG D 1 52 ? 109.479 -51.069 16.981 1.00 25.14 ? 376 ARG D NE 1 ATOM 5286 C CZ . ARG D 1 52 ? 110.760 -51.179 16.663 1.00 25.78 ? 376 ARG D CZ 1 ATOM 5287 N NH1 . ARG D 1 52 ? 111.124 -51.476 15.422 1.00 26.94 ? 376 ARG D NH1 1 ATOM 5288 N NH2 . ARG D 1 52 ? 111.674 -50.963 17.587 1.00 25.97 ? 376 ARG D NH2 1 ATOM 5289 N N . ALA D 1 53 ? 104.267 -53.939 14.012 1.00 22.23 ? 377 ALA D N 1 ATOM 5290 C CA . ALA D 1 53 ? 103.877 -55.170 13.347 1.00 19.65 ? 377 ALA D CA 1 ATOM 5291 C C . ALA D 1 53 ? 104.960 -56.220 13.475 1.00 20.22 ? 377 ALA D C 1 ATOM 5292 O O . ALA D 1 53 ? 104.650 -57.421 13.429 1.00 20.91 ? 377 ALA D O 1 ATOM 5293 C CB . ALA D 1 53 ? 103.533 -54.918 11.889 1.00 17.63 ? 377 ALA D CB 1 ATOM 5294 N N . SER D 1 54 ? 106.218 -55.779 13.609 1.00 20.09 ? 378 SER D N 1 ATOM 5295 C CA . SER D 1 54 ? 107.364 -56.689 13.828 1.00 19.06 ? 378 SER D CA 1 ATOM 5296 C C . SER D 1 54 ? 107.382 -57.320 15.223 1.00 18.10 ? 378 SER D C 1 ATOM 5297 O O . SER D 1 54 ? 108.054 -58.312 15.456 1.00 14.08 ? 378 SER D O 1 ATOM 5298 C CB . SER D 1 54 ? 108.671 -55.935 13.653 1.00 18.76 ? 378 SER D CB 1 ATOM 5299 O OG . SER D 1 54 ? 108.821 -55.033 14.736 1.00 20.30 ? 378 SER D OG 1 ATOM 5300 N N . GLY D 1 55 ? 106.645 -56.738 16.161 1.00 20.13 ? 379 GLY D N 1 ATOM 5301 C CA . GLY D 1 55 ? 106.621 -57.259 17.523 1.00 22.02 ? 379 GLY D CA 1 ATOM 5302 C C . GLY D 1 55 ? 107.702 -56.636 18.400 1.00 23.78 ? 379 GLY D C 1 ATOM 5303 O O . GLY D 1 55 ? 107.819 -56.961 19.579 1.00 24.10 ? 379 GLY D O 1 ATOM 5304 N N . LYS D 1 56 ? 108.504 -55.736 17.841 1.00 25.01 ? 380 LYS D N 1 ATOM 5305 C CA . LYS D 1 56 ? 109.605 -55.160 18.601 1.00 26.27 ? 380 LYS D CA 1 ATOM 5306 C C . LYS D 1 56 ? 109.094 -54.028 19.503 1.00 25.82 ? 380 LYS D C 1 ATOM 5307 O O . LYS D 1 56 ? 107.989 -53.534 19.313 1.00 26.41 ? 380 LYS D O 1 ATOM 5308 C CB . LYS D 1 56 ? 110.702 -54.682 17.656 1.00 27.63 ? 380 LYS D CB 1 ATOM 5309 C CG . LYS D 1 56 ? 111.366 -55.756 16.825 1.00 28.17 ? 380 LYS D CG 1 ATOM 5310 C CD . LYS D 1 56 ? 112.255 -55.130 15.729 1.00 29.73 ? 380 LYS D CD 1 ATOM 5311 C CE . LYS D 1 56 ? 113.085 -56.193 15.010 1.00 31.48 ? 380 LYS D CE 1 ATOM 5312 N NZ . LYS D 1 56 ? 113.973 -55.644 13.933 1.00 32.37 ? 380 LYS D NZ 1 ATOM 5313 N N . PRO D 1 57 ? 109.887 -53.619 20.503 1.00 26.63 ? 381 PRO D N 1 ATOM 5314 C CA . PRO D 1 57 ? 109.324 -52.734 21.504 1.00 27.59 ? 381 PRO D CA 1 ATOM 5315 C C . PRO D 1 57 ? 109.125 -51.315 20.963 1.00 30.02 ? 381 PRO D C 1 ATOM 5316 O O . PRO D 1 57 ? 109.813 -50.891 20.025 1.00 31.40 ? 381 PRO D O 1 ATOM 5317 C CB . PRO D 1 57 ? 110.384 -52.739 22.625 1.00 27.52 ? 381 PRO D CB 1 ATOM 5318 C CG . PRO D 1 57 ? 111.357 -53.862 22.294 1.00 26.42 ? 381 PRO D CG 1 ATOM 5319 C CD . PRO D 1 57 ? 111.288 -53.970 20.807 1.00 26.99 ? 381 PRO D CD 1 ATOM 5320 N N . VAL D 1 58 ? 108.199 -50.592 21.580 1.00 29.54 ? 382 VAL D N 1 ATOM 5321 C CA . VAL D 1 58 ? 107.982 -49.195 21.298 1.00 29.36 ? 382 VAL D CA 1 ATOM 5322 C C . VAL D 1 58 ? 108.333 -48.354 22.522 1.00 30.83 ? 382 VAL D C 1 ATOM 5323 O O . VAL D 1 58 ? 108.252 -48.810 23.652 1.00 30.41 ? 382 VAL D O 1 ATOM 5324 C CB . VAL D 1 58 ? 106.489 -48.917 21.031 1.00 30.39 ? 382 VAL D CB 1 ATOM 5325 C CG1 . VAL D 1 58 ? 105.994 -49.601 19.734 1.00 28.97 ? 382 VAL D CG1 1 ATOM 5326 C CG2 . VAL D 1 58 ? 105.667 -49.339 22.264 1.00 28.76 ? 382 VAL D CG2 1 ATOM 5327 N N . GLN D 1 59 ? 108.690 -47.103 22.266 1.00 32.41 ? 383 GLN D N 1 ATOM 5328 C CA . GLN D 1 59 ? 109.059 -46.147 23.276 1.00 33.70 ? 383 GLN D CA 1 ATOM 5329 C C . GLN D 1 59 ? 107.815 -45.609 23.971 1.00 32.74 ? 383 GLN D C 1 ATOM 5330 O O . GLN D 1 59 ? 106.684 -45.904 23.588 1.00 30.92 ? 383 GLN D O 1 ATOM 5331 C CB . GLN D 1 59 ? 109.796 -44.990 22.590 1.00 36.46 ? 383 GLN D CB 1 ATOM 5332 C CG . GLN D 1 59 ? 111.109 -45.359 21.901 1.00 37.93 ? 383 GLN D CG 1 ATOM 5333 C CD . GLN D 1 59 ? 111.836 -44.119 21.375 1.00 41.05 ? 383 GLN D CD 1 ATOM 5334 O OE1 . GLN D 1 59 ? 111.801 -43.057 21.993 1.00 43.38 ? 383 GLN D OE1 1 ATOM 5335 N NE2 . GLN D 1 59 ? 112.500 -44.252 20.233 1.00 42.41 ? 383 GLN D NE2 1 ATOM 5336 N N . HIS D 1 60 ? 108.034 -44.794 24.991 1.00 32.88 ? 384 HIS D N 1 ATOM 5337 C CA . HIS D 1 60 ? 106.937 -44.198 25.743 1.00 34.57 ? 384 HIS D CA 1 ATOM 5338 C C . HIS D 1 60 ? 106.204 -43.141 24.929 1.00 34.27 ? 384 HIS D C 1 ATOM 5339 O O . HIS D 1 60 ? 106.832 -42.324 24.244 1.00 35.31 ? 384 HIS D O 1 ATOM 5340 C CB . HIS D 1 60 ? 107.455 -43.582 27.046 1.00 36.64 ? 384 HIS D CB 1 ATOM 5341 C CG . HIS D 1 60 ? 107.962 -44.587 28.036 1.00 38.18 ? 384 HIS D CG 1 ATOM 5342 N ND1 . HIS D 1 60 ? 107.160 -45.572 28.570 1.00 39.30 ? 384 HIS D ND1 1 ATOM 5343 C CD2 . HIS D 1 60 ? 109.187 -44.752 28.594 1.00 39.35 ? 384 HIS D CD2 1 ATOM 5344 C CE1 . HIS D 1 60 ? 107.869 -46.305 29.410 1.00 40.31 ? 384 HIS D CE1 1 ATOM 5345 N NE2 . HIS D 1 60 ? 109.105 -45.833 29.437 1.00 39.92 ? 384 HIS D NE2 1 ATOM 5346 N N . SER D 1 61 ? 104.876 -43.161 24.992 1.00 33.55 ? 385 SER D N 1 ATOM 5347 C CA . SER D 1 61 ? 104.099 -42.184 24.255 1.00 34.61 ? 385 SER D CA 1 ATOM 5348 C C . SER D 1 61 ? 103.593 -41.067 25.159 1.00 35.53 ? 385 SER D C 1 ATOM 5349 O O . SER D 1 61 ? 103.480 -41.246 26.365 1.00 35.45 ? 385 SER D O 1 ATOM 5350 C CB . SER D 1 61 ? 102.939 -42.857 23.527 1.00 34.68 ? 385 SER D CB 1 ATOM 5351 O OG . SER D 1 61 ? 102.102 -43.582 24.409 1.00 35.52 ? 385 SER D OG 1 ATOM 5352 N N . THR D 1 62 ? 103.297 -39.921 24.553 1.00 38.66 ? 386 THR D N 1 ATOM 5353 C CA . THR D 1 62 ? 102.702 -38.765 25.232 1.00 39.69 ? 386 THR D CA 1 ATOM 5354 C C . THR D 1 62 ? 101.214 -38.708 24.899 1.00 40.97 ? 386 THR D C 1 ATOM 5355 O O . THR D 1 62 ? 100.847 -38.827 23.731 1.00 41.57 ? 386 THR D O 1 ATOM 5356 C CB . THR D 1 62 ? 103.315 -37.446 24.742 1.00 40.19 ? 386 THR D CB 1 ATOM 5357 O OG1 . THR D 1 62 ? 104.680 -37.353 25.163 1.00 39.93 ? 386 THR D OG1 1 ATOM 5358 C CG2 . THR D 1 62 ? 102.529 -36.245 25.316 1.00 42.22 ? 386 THR D CG2 1 ATOM 5359 N N . ARG D 1 63 ? 100.365 -38.523 25.908 1.00 40.89 ? 387 ARG D N 1 ATOM 5360 C CA . ARG D 1 63 ? 98.916 -38.534 25.716 1.00 42.21 ? 387 ARG D CA 1 ATOM 5361 C C . ARG D 1 63 ? 98.290 -37.176 26.038 1.00 43.04 ? 387 ARG D C 1 ATOM 5362 O O . ARG D 1 63 ? 98.734 -36.482 26.940 1.00 42.48 ? 387 ARG D O 1 ATOM 5363 C CB . ARG D 1 63 ? 98.289 -39.591 26.619 1.00 43.03 ? 387 ARG D CB 1 ATOM 5364 C CG . ARG D 1 63 ? 96.791 -39.775 26.414 1.00 44.52 ? 387 ARG D CG 1 ATOM 5365 C CD . ARG D 1 63 ? 96.162 -40.488 27.591 1.00 45.95 ? 387 ARG D CD 1 ATOM 5366 N NE . ARG D 1 63 ? 94.704 -40.469 27.541 1.00 47.41 ? 387 ARG D NE 1 ATOM 5367 C CZ . ARG D 1 63 ? 93.950 -41.501 27.169 1.00 48.48 ? 387 ARG D CZ 1 ATOM 5368 N NH1 . ARG D 1 63 ? 94.499 -42.655 26.807 1.00 49.20 ? 387 ARG D NH1 1 ATOM 5369 N NH2 . ARG D 1 63 ? 92.633 -41.380 27.167 1.00 48.63 ? 387 ARG D NH2 1 ATOM 5370 N N . LYS D 1 64 ? 97.243 -36.797 25.317 1.00 44.19 ? 388 LYS D N 1 ATOM 5371 C CA . LYS D 1 64 ? 96.717 -35.453 25.419 1.00 45.47 ? 388 LYS D CA 1 ATOM 5372 C C . LYS D 1 64 ? 95.214 -35.416 25.135 1.00 46.69 ? 388 LYS D C 1 ATOM 5373 O O . LYS D 1 64 ? 94.773 -35.755 24.037 1.00 47.26 ? 388 LYS D O 1 ATOM 5374 C CB . LYS D 1 64 ? 97.481 -34.562 24.445 1.00 46.86 ? 388 LYS D CB 1 ATOM 5375 C CG . LYS D 1 64 ? 97.348 -33.097 24.718 1.00 49.25 ? 388 LYS D CG 1 ATOM 5376 C CD . LYS D 1 64 ? 98.076 -32.272 23.670 1.00 51.45 ? 388 LYS D CD 1 ATOM 5377 C CE . LYS D 1 64 ? 97.867 -30.782 23.932 1.00 52.76 ? 388 LYS D CE 1 ATOM 5378 N NZ . LYS D 1 64 ? 98.397 -29.911 22.827 1.00 53.84 ? 388 LYS D NZ 1 ATOM 5379 N N . GLU D 1 65 ? 94.434 -35.007 26.134 1.00 47.50 ? 389 GLU D N 1 ATOM 5380 C CA . GLU D 1 65 ? 92.977 -34.940 26.039 1.00 47.81 ? 389 GLU D CA 1 ATOM 5381 C C . GLU D 1 65 ? 92.498 -33.513 26.184 1.00 48.31 ? 389 GLU D C 1 ATOM 5382 O O . GLU D 1 65 ? 93.077 -32.735 26.946 1.00 48.40 ? 389 GLU D O 1 ATOM 5383 C CB . GLU D 1 65 ? 92.322 -35.718 27.178 1.00 48.65 ? 389 GLU D CB 1 ATOM 5384 C CG . GLU D 1 65 ? 92.696 -37.186 27.272 1.00 50.05 ? 389 GLU D CG 1 ATOM 5385 C CD . GLU D 1 65 ? 91.844 -37.893 28.294 1.00 50.41 ? 389 GLU D CD 1 ATOM 5386 O OE1 . GLU D 1 65 ? 90.614 -37.712 28.206 1.00 51.71 ? 389 GLU D OE1 1 ATOM 5387 O OE2 . GLU D 1 65 ? 92.381 -38.602 29.174 1.00 49.95 ? 389 GLU D OE2 1 ATOM 5388 N N . GLU D 1 66 ? 91.416 -33.188 25.481 1.00 48.57 ? 390 GLU D N 1 ATOM 5389 C CA . GLU D 1 66 ? 90.750 -31.900 25.632 1.00 48.76 ? 390 GLU D CA 1 ATOM 5390 C C . GLU D 1 66 ? 89.296 -31.992 25.188 1.00 48.46 ? 390 GLU D C 1 ATOM 5391 O O . GLU D 1 66 ? 89.019 -32.562 24.138 1.00 46.80 ? 390 GLU D O 1 ATOM 5392 C CB . GLU D 1 66 ? 91.459 -30.845 24.786 1.00 49.66 ? 390 GLU D CB 1 ATOM 5393 C CG . GLU D 1 66 ? 90.713 -29.526 24.690 1.00 50.46 ? 390 GLU D CG 1 ATOM 5394 C CD . GLU D 1 66 ? 91.587 -28.390 24.193 1.00 51.30 ? 390 GLU D CD 1 ATOM 5395 O OE1 . GLU D 1 66 ? 92.676 -28.680 23.655 1.00 52.41 ? 390 GLU D OE1 1 ATOM 5396 O OE2 . GLU D 1 66 ? 91.187 -27.210 24.347 1.00 51.80 ? 390 GLU D OE2 1 ATOM 5397 N N . LYS D 1 67 ? 88.379 -31.435 25.980 1.00 48.45 ? 391 LYS D N 1 ATOM 5398 C CA . LYS D 1 67 ? 86.995 -31.256 25.543 1.00 49.09 ? 391 LYS D CA 1 ATOM 5399 C C . LYS D 1 67 ? 86.885 -30.022 24.658 1.00 48.78 ? 391 LYS D C 1 ATOM 5400 O O . LYS D 1 67 ? 87.394 -28.958 24.999 1.00 48.32 ? 391 LYS D O 1 ATOM 5401 C CB . LYS D 1 67 ? 86.042 -31.138 26.738 1.00 50.65 ? 391 LYS D CB 1 ATOM 5402 C CG . LYS D 1 67 ? 85.905 -32.430 27.528 1.00 52.07 ? 391 LYS D CG 1 ATOM 5403 C CD . LYS D 1 67 ? 84.840 -32.386 28.619 1.00 52.63 ? 391 LYS D CD 1 ATOM 5404 C CE . LYS D 1 67 ? 84.766 -33.753 29.315 1.00 53.43 ? 391 LYS D CE 1 ATOM 5405 N NZ . LYS D 1 67 ? 83.570 -33.956 30.198 1.00 53.68 ? 391 LYS D NZ 1 ATOM 5406 N N . GLN D 1 68 ? 86.226 -30.175 23.515 1.00 49.84 ? 392 GLN D N 1 ATOM 5407 C CA . GLN D 1 68 ? 86.072 -29.092 22.549 1.00 51.28 ? 392 GLN D CA 1 ATOM 5408 C C . GLN D 1 68 ? 84.722 -28.407 22.762 1.00 53.14 ? 392 GLN D C 1 ATOM 5409 O O . GLN D 1 68 ? 83.850 -28.932 23.462 1.00 53.30 ? 392 GLN D O 1 ATOM 5410 C CB . GLN D 1 68 ? 86.136 -29.633 21.119 1.00 51.27 ? 392 GLN D CB 1 ATOM 5411 C CG . GLN D 1 68 ? 87.319 -30.552 20.813 1.00 51.65 ? 392 GLN D CG 1 ATOM 5412 C CD . GLN D 1 68 ? 88.670 -29.867 20.939 1.00 51.39 ? 392 GLN D CD 1 ATOM 5413 O OE1 . GLN D 1 68 ? 88.815 -28.678 20.654 1.00 52.28 ? 392 GLN D OE1 1 ATOM 5414 N NE2 . GLN D 1 68 ? 89.669 -30.624 21.366 1.00 51.64 ? 392 GLN D NE2 1 ATOM 5415 N N . ARG D 1 69 ? 84.548 -27.240 22.149 1.00 54.51 ? 393 ARG D N 1 ATOM 5416 C CA . ARG D 1 69 ? 83.355 -26.433 22.376 1.00 55.67 ? 393 ARG D CA 1 ATOM 5417 C C . ARG D 1 69 ? 82.075 -27.068 21.843 1.00 55.16 ? 393 ARG D C 1 ATOM 5418 O O . ARG D 1 69 ? 81.002 -26.829 22.392 1.00 54.18 ? 393 ARG D O 1 ATOM 5419 C CB . ARG D 1 69 ? 83.544 -25.042 21.782 1.00 57.32 ? 393 ARG D CB 1 ATOM 5420 C CG . ARG D 1 69 ? 84.582 -24.238 22.539 1.00 59.06 ? 393 ARG D CG 1 ATOM 5421 C CD . ARG D 1 69 ? 84.417 -22.740 22.322 1.00 60.20 ? 393 ARG D CD 1 ATOM 5422 N NE . ARG D 1 69 ? 85.583 -22.026 22.838 1.00 61.22 ? 393 ARG D NE 1 ATOM 5423 C CZ . ARG D 1 69 ? 85.896 -20.769 22.537 1.00 61.68 ? 393 ARG D CZ 1 ATOM 5424 N NH1 . ARG D 1 69 ? 85.125 -20.064 21.717 1.00 61.80 ? 393 ARG D NH1 1 ATOM 5425 N NH2 . ARG D 1 69 ? 86.987 -20.221 23.062 1.00 62.06 ? 393 ARG D NH2 1 ATOM 5426 N N . ASN D 1 70 ? 82.187 -27.885 20.796 1.00 54.88 ? 394 ASN D N 1 ATOM 5427 C CA . ASN D 1 70 ? 81.022 -28.571 20.222 1.00 54.12 ? 394 ASN D CA 1 ATOM 5428 C C . ASN D 1 70 ? 80.599 -29.840 20.972 1.00 52.99 ? 394 ASN D C 1 ATOM 5429 O O . ASN D 1 70 ? 79.828 -30.647 20.459 1.00 50.95 ? 394 ASN D O 1 ATOM 5430 C CB . ASN D 1 70 ? 81.234 -28.852 18.726 1.00 54.79 ? 394 ASN D CB 1 ATOM 5431 C CG . ASN D 1 70 ? 82.430 -29.750 18.440 1.00 55.88 ? 394 ASN D CG 1 ATOM 5432 O OD1 . ASN D 1 70 ? 82.947 -30.428 19.327 1.00 54.71 ? 394 ASN D OD1 1 ATOM 5433 N ND2 . ASN D 1 70 ? 82.864 -29.760 17.174 1.00 57.49 ? 394 ASN D ND2 1 ATOM 5434 N N . GLY D 1 71 ? 81.102 -29.994 22.195 1.00 53.30 ? 395 GLY D N 1 ATOM 5435 C CA . GLY D 1 71 ? 80.788 -31.136 23.049 1.00 53.39 ? 395 GLY D CA 1 ATOM 5436 C C . GLY D 1 71 ? 81.534 -32.405 22.677 1.00 53.73 ? 395 GLY D C 1 ATOM 5437 O O . GLY D 1 71 ? 81.067 -33.508 22.979 1.00 54.84 ? 395 GLY D O 1 ATOM 5438 N N . THR D 1 72 ? 82.694 -32.261 22.031 1.00 53.10 ? 396 THR D N 1 ATOM 5439 C CA . THR D 1 72 ? 83.409 -33.411 21.459 1.00 52.60 ? 396 THR D CA 1 ATOM 5440 C C . THR D 1 72 ? 84.697 -33.678 22.213 1.00 50.54 ? 396 THR D C 1 ATOM 5441 O O . THR D 1 72 ? 85.465 -32.751 22.446 1.00 50.62 ? 396 THR D O 1 ATOM 5442 C CB . THR D 1 72 ? 83.838 -33.141 20.004 1.00 53.10 ? 396 THR D CB 1 ATOM 5443 O OG1 . THR D 1 72 ? 82.686 -33.091 19.151 1.00 53.65 ? 396 THR D OG1 1 ATOM 5444 C CG2 . THR D 1 72 ? 84.788 -34.217 19.523 1.00 53.45 ? 396 THR D CG2 1 ATOM 5445 N N . LEU D 1 73 ? 84.935 -34.932 22.583 1.00 48.33 ? 397 LEU D N 1 ATOM 5446 C CA . LEU D 1 73 ? 86.212 -35.318 23.178 1.00 46.93 ? 397 LEU D CA 1 ATOM 5447 C C . LEU D 1 73 ? 87.248 -35.656 22.094 1.00 45.62 ? 397 LEU D C 1 ATOM 5448 O O . LEU D 1 73 ? 87.000 -36.437 21.175 1.00 45.74 ? 397 LEU D O 1 ATOM 5449 C CB . LEU D 1 73 ? 86.028 -36.496 24.135 1.00 46.83 ? 397 LEU D CB 1 ATOM 5450 C CG . LEU D 1 73 ? 87.302 -36.932 24.854 1.00 46.99 ? 397 LEU D CG 1 ATOM 5451 C CD1 . LEU D 1 73 ? 87.715 -35.877 25.860 1.00 47.09 ? 397 LEU D CD1 1 ATOM 5452 C CD2 . LEU D 1 73 ? 87.103 -38.279 25.532 1.00 47.63 ? 397 LEU D CD2 1 ATOM 5453 N N . THR D 1 74 ? 88.419 -35.048 22.209 1.00 43.12 ? 398 THR D N 1 ATOM 5454 C CA . THR D 1 74 ? 89.509 -35.292 21.293 1.00 40.31 ? 398 THR D CA 1 ATOM 5455 C C . THR D 1 74 ? 90.658 -35.858 22.112 1.00 38.92 ? 398 THR D C 1 ATOM 5456 O O . THR D 1 74 ? 91.047 -35.271 23.105 1.00 38.90 ? 398 THR D O 1 ATOM 5457 C CB . THR D 1 74 ? 89.885 -33.986 20.592 1.00 40.01 ? 398 THR D CB 1 ATOM 5458 O OG1 . THR D 1 74 ? 88.961 -33.764 19.520 1.00 40.87 ? 398 THR D OG1 1 ATOM 5459 C CG2 . THR D 1 74 ? 91.289 -34.020 20.039 1.00 39.56 ? 398 THR D CG2 1 ATOM 5460 N N . VAL D 1 75 ? 91.173 -37.018 21.714 1.00 38.16 ? 399 VAL D N 1 ATOM 5461 C CA . VAL D 1 75 ? 92.330 -37.617 22.365 1.00 37.89 ? 399 VAL D CA 1 ATOM 5462 C C . VAL D 1 75 ? 93.425 -37.944 21.348 1.00 38.33 ? 399 VAL D C 1 ATOM 5463 O O . VAL D 1 75 ? 93.157 -38.462 20.267 1.00 38.06 ? 399 VAL D O 1 ATOM 5464 C CB . VAL D 1 75 ? 91.970 -38.918 23.086 1.00 37.42 ? 399 VAL D CB 1 ATOM 5465 C CG1 . VAL D 1 75 ? 93.201 -39.488 23.758 1.00 36.72 ? 399 VAL D CG1 1 ATOM 5466 C CG2 . VAL D 1 75 ? 90.852 -38.684 24.080 1.00 37.30 ? 399 VAL D CG2 1 ATOM 5467 N N . THR D 1 76 ? 94.669 -37.644 21.696 1.00 37.96 ? 400 THR D N 1 ATOM 5468 C CA . THR D 1 76 ? 95.761 -37.832 20.765 1.00 37.73 ? 400 THR D CA 1 ATOM 5469 C C . THR D 1 76 ? 96.958 -38.390 21.506 1.00 37.04 ? 400 THR D C 1 ATOM 5470 O O . THR D 1 76 ? 97.192 -38.098 22.675 1.00 39.50 ? 400 THR D O 1 ATOM 5471 C CB . THR D 1 76 ? 96.165 -36.527 20.051 1.00 38.29 ? 400 THR D CB 1 ATOM 5472 O OG1 . THR D 1 76 ? 96.796 -35.639 20.976 1.00 38.79 ? 400 THR D OG1 1 ATOM 5473 C CG2 . THR D 1 76 ? 94.942 -35.846 19.471 1.00 40.82 ? 400 THR D CG2 1 ATOM 5474 N N . SER D 1 77 ? 97.729 -39.199 20.805 1.00 35.16 ? 401 SER D N 1 ATOM 5475 C CA . SER D 1 77 ? 98.844 -39.857 21.413 1.00 33.98 ? 401 SER D CA 1 ATOM 5476 C C . SER D 1 77 ? 99.978 -39.815 20.417 1.00 34.26 ? 401 SER D C 1 ATOM 5477 O O . SER D 1 77 ? 99.804 -40.191 19.260 1.00 34.88 ? 401 SER D O 1 ATOM 5478 C CB . SER D 1 77 ? 98.480 -41.288 21.746 1.00 33.83 ? 401 SER D CB 1 ATOM 5479 O OG . SER D 1 77 ? 99.387 -41.766 22.700 1.00 35.07 ? 401 SER D OG 1 ATOM 5480 N N . THR D 1 78 ? 101.125 -39.322 20.867 1.00 33.58 ? 402 THR D N 1 ATOM 5481 C CA . THR D 1 78 ? 102.286 -39.145 20.014 1.00 31.99 ? 402 THR D CA 1 ATOM 5482 C C . THR D 1 78 ? 103.359 -40.114 20.469 1.00 29.95 ? 402 THR D C 1 ATOM 5483 O O . THR D 1 78 ? 103.715 -40.177 21.650 1.00 27.75 ? 402 THR D O 1 ATOM 5484 C CB . THR D 1 78 ? 102.796 -37.695 20.104 1.00 32.68 ? 402 THR D CB 1 ATOM 5485 O OG1 . THR D 1 78 ? 101.750 -36.822 19.674 1.00 32.52 ? 402 THR D OG1 1 ATOM 5486 C CG2 . THR D 1 78 ? 104.049 -37.481 19.238 1.00 33.09 ? 402 THR D CG2 1 ATOM 5487 N N . LEU D 1 79 ? 103.852 -40.894 19.521 1.00 29.65 ? 403 LEU D N 1 ATOM 5488 C CA . LEU D 1 79 ? 104.847 -41.918 19.810 1.00 27.36 ? 403 LEU D CA 1 ATOM 5489 C C . LEU D 1 79 ? 106.073 -41.528 19.046 1.00 28.60 ? 403 LEU D C 1 ATOM 5490 O O . LEU D 1 79 ? 106.015 -41.348 17.833 1.00 29.40 ? 403 LEU D O 1 ATOM 5491 C CB . LEU D 1 79 ? 104.384 -43.271 19.312 1.00 27.20 ? 403 LEU D CB 1 ATOM 5492 C CG . LEU D 1 79 ? 105.355 -44.448 19.437 1.00 27.64 ? 403 LEU D CG 1 ATOM 5493 C CD1 . LEU D 1 79 ? 105.616 -44.760 20.921 1.00 26.42 ? 403 LEU D CD1 1 ATOM 5494 C CD2 . LEU D 1 79 ? 104.783 -45.650 18.688 1.00 24.86 ? 403 LEU D CD2 1 ATOM 5495 N N . PRO D 1 80 ? 107.198 -41.384 19.746 1.00 28.13 ? 404 PRO D N 1 ATOM 5496 C CA . PRO D 1 80 ? 108.480 -41.272 19.061 1.00 28.62 ? 404 PRO D CA 1 ATOM 5497 C C . PRO D 1 80 ? 108.850 -42.599 18.391 1.00 28.46 ? 404 PRO D C 1 ATOM 5498 O O . PRO D 1 80 ? 108.593 -43.651 18.953 1.00 31.14 ? 404 PRO D O 1 ATOM 5499 C CB . PRO D 1 80 ? 109.464 -40.964 20.199 1.00 29.52 ? 404 PRO D CB 1 ATOM 5500 C CG . PRO D 1 80 ? 108.638 -40.630 21.374 1.00 29.07 ? 404 PRO D CG 1 ATOM 5501 C CD . PRO D 1 80 ? 107.339 -41.358 21.202 1.00 28.08 ? 404 PRO D CD 1 ATOM 5502 N N . VAL D 1 81 ? 109.432 -42.556 17.199 1.00 26.92 ? 405 VAL D N 1 ATOM 5503 C CA . VAL D 1 81 ? 109.890 -43.751 16.525 1.00 26.11 ? 405 VAL D CA 1 ATOM 5504 C C . VAL D 1 81 ? 111.346 -43.575 16.095 1.00 27.47 ? 405 VAL D C 1 ATOM 5505 O O . VAL D 1 81 ? 111.862 -42.463 16.008 1.00 27.46 ? 405 VAL D O 1 ATOM 5506 C CB . VAL D 1 81 ? 109.057 -44.032 15.258 1.00 27.79 ? 405 VAL D CB 1 ATOM 5507 C CG1 . VAL D 1 81 ? 107.619 -44.403 15.628 1.00 26.89 ? 405 VAL D CG1 1 ATOM 5508 C CG2 . VAL D 1 81 ? 109.070 -42.820 14.309 1.00 26.12 ? 405 VAL D CG2 1 ATOM 5509 N N . GLY D 1 82 ? 112.018 -44.688 15.834 1.00 28.34 ? 406 GLY D N 1 ATOM 5510 C CA . GLY D 1 82 ? 113.413 -44.666 15.450 1.00 27.93 ? 406 GLY D CA 1 ATOM 5511 C C . GLY D 1 82 ? 113.501 -44.104 14.050 1.00 28.78 ? 406 GLY D C 1 ATOM 5512 O O . GLY D 1 82 ? 112.656 -44.399 13.203 1.00 31.53 ? 406 GLY D O 1 ATOM 5513 N N . THR D 1 83 ? 114.507 -43.286 13.790 1.00 28.36 ? 407 THR D N 1 ATOM 5514 C CA . THR D 1 83 ? 114.636 -42.710 12.473 1.00 29.78 ? 407 THR D CA 1 ATOM 5515 C C . THR D 1 83 ? 114.941 -43.809 11.465 1.00 31.07 ? 407 THR D C 1 ATOM 5516 O O . THR D 1 83 ? 114.276 -43.908 10.429 1.00 30.35 ? 407 THR D O 1 ATOM 5517 C CB . THR D 1 83 ? 115.718 -41.652 12.448 1.00 30.36 ? 407 THR D CB 1 ATOM 5518 O OG1 . THR D 1 83 ? 115.371 -40.623 13.374 1.00 32.06 ? 407 THR D OG1 1 ATOM 5519 C CG2 . THR D 1 83 ? 115.853 -41.064 11.070 1.00 30.53 ? 407 THR D CG2 1 ATOM 5520 N N . ARG D 1 84 ? 115.938 -44.637 11.752 1.00 32.04 ? 408 ARG D N 1 ATOM 5521 C CA . ARG D 1 84 ? 116.224 -45.750 10.850 1.00 34.95 ? 408 ARG D CA 1 ATOM 5522 C C . ARG D 1 84 ? 115.084 -46.782 10.797 1.00 34.69 ? 408 ARG D C 1 ATOM 5523 O O . ARG D 1 84 ? 114.695 -47.209 9.714 1.00 37.53 ? 408 ARG D O 1 ATOM 5524 C CB . ARG D 1 84 ? 117.556 -46.426 11.171 1.00 37.06 ? 408 ARG D CB 1 ATOM 5525 C CG . ARG D 1 84 ? 118.028 -47.327 10.033 1.00 41.16 ? 408 ARG D CG 1 ATOM 5526 C CD . ARG D 1 84 ? 119.487 -47.800 10.151 1.00 43.53 ? 408 ARG D CD 1 ATOM 5527 N NE . ARG D 1 84 ? 120.012 -48.380 8.907 1.00 45.51 ? 408 ARG D NE 1 ATOM 5528 C CZ . ARG D 1 84 ? 121.203 -48.978 8.795 1.00 47.75 ? 408 ARG D CZ 1 ATOM 5529 N NH1 . ARG D 1 84 ? 122.012 -49.091 9.846 1.00 48.29 ? 408 ARG D NH1 1 ATOM 5530 N NH2 . ARG D 1 84 ? 121.604 -49.474 7.627 1.00 48.25 ? 408 ARG D NH2 1 ATOM 5531 N N . ASP D 1 85 ? 114.532 -47.184 11.939 1.00 32.66 ? 409 ASP D N 1 ATOM 5532 C CA . ASP D 1 85 ? 113.370 -48.074 11.945 1.00 30.85 ? 409 ASP D CA 1 ATOM 5533 C C . ASP D 1 85 ? 112.281 -47.560 11.001 1.00 30.38 ? 409 ASP D C 1 ATOM 5534 O O . ASP D 1 85 ? 111.617 -48.343 10.309 1.00 28.61 ? 409 ASP D O 1 ATOM 5535 C CB . ASP D 1 85 ? 112.743 -48.185 13.339 1.00 30.41 ? 409 ASP D CB 1 ATOM 5536 C CG . ASP D 1 85 ? 113.570 -49.004 14.327 1.00 30.59 ? 409 ASP D CG 1 ATOM 5537 O OD1 . ASP D 1 85 ? 114.527 -49.707 13.919 1.00 28.24 ? 409 ASP D OD1 1 ATOM 5538 O OD2 . ASP D 1 85 ? 113.225 -48.935 15.545 1.00 31.15 ? 409 ASP D OD2 1 ATOM 5539 N N . TRP D 1 86 ? 112.072 -46.247 10.995 1.00 29.45 ? 410 TRP D N 1 ATOM 5540 C CA . TRP D 1 86 ? 111.007 -45.684 10.176 1.00 30.31 ? 410 TRP D CA 1 ATOM 5541 C C . TRP D 1 86 ? 111.355 -45.641 8.686 1.00 31.75 ? 410 TRP D C 1 ATOM 5542 O O . TRP D 1 86 ? 110.505 -45.962 7.852 1.00 31.64 ? 410 TRP D O 1 ATOM 5543 C CB . TRP D 1 86 ? 110.576 -44.275 10.618 1.00 29.15 ? 410 TRP D CB 1 ATOM 5544 C CG . TRP D 1 86 ? 109.581 -43.739 9.624 1.00 26.80 ? 410 TRP D CG 1 ATOM 5545 C CD1 . TRP D 1 86 ? 109.856 -43.030 8.521 1.00 25.95 ? 410 TRP D CD1 1 ATOM 5546 C CD2 . TRP D 1 86 ? 108.161 -43.926 9.647 1.00 26.33 ? 410 TRP D CD2 1 ATOM 5547 N NE1 . TRP D 1 86 ? 108.701 -42.752 7.841 1.00 27.50 ? 410 TRP D NE1 1 ATOM 5548 C CE2 . TRP D 1 86 ? 107.641 -43.296 8.511 1.00 26.61 ? 410 TRP D CE2 1 ATOM 5549 C CE3 . TRP D 1 86 ? 107.285 -44.562 10.520 1.00 26.48 ? 410 TRP D CE3 1 ATOM 5550 C CZ2 . TRP D 1 86 ? 106.281 -43.280 8.219 1.00 26.04 ? 410 TRP D CZ2 1 ATOM 5551 C CZ3 . TRP D 1 86 ? 105.952 -44.550 10.235 1.00 26.79 ? 410 TRP D CZ3 1 ATOM 5552 C CH2 . TRP D 1 86 ? 105.453 -43.911 9.098 1.00 25.93 ? 410 TRP D CH2 1 ATOM 5553 N N . ILE D 1 87 ? 112.586 -45.244 8.367 1.00 33.64 ? 411 ILE D N 1 ATOM 5554 C CA . ILE D 1 87 ? 113.050 -45.155 6.976 1.00 35.81 ? 411 ILE D CA 1 ATOM 5555 C C . ILE D 1 87 ? 113.149 -46.544 6.335 1.00 37.67 ? 411 ILE D C 1 ATOM 5556 O O . ILE D 1 87 ? 112.959 -46.714 5.124 1.00 40.23 ? 411 ILE D O 1 ATOM 5557 C CB . ILE D 1 87 ? 114.402 -44.387 6.885 1.00 35.91 ? 411 ILE D CB 1 ATOM 5558 C CG1 . ILE D 1 87 ? 114.163 -42.897 7.175 1.00 35.49 ? 411 ILE D CG1 1 ATOM 5559 C CG2 . ILE D 1 87 ? 115.079 -44.551 5.509 1.00 34.11 ? 411 ILE D CG2 1 ATOM 5560 C CD1 . ILE D 1 87 ? 115.406 -42.034 6.998 1.00 35.20 ? 411 ILE D CD1 1 ATOM 5561 N N . GLU D 1 88 ? 113.401 -47.556 7.154 1.00 38.57 ? 412 GLU D N 1 ATOM 5562 C CA . GLU D 1 88 ? 113.467 -48.918 6.651 1.00 37.78 ? 412 GLU D CA 1 ATOM 5563 C C . GLU D 1 88 ? 112.122 -49.606 6.549 1.00 35.54 ? 412 GLU D C 1 ATOM 5564 O O . GLU D 1 88 ? 112.052 -50.771 6.184 1.00 34.28 ? 412 GLU D O 1 ATOM 5565 C CB . GLU D 1 88 ? 114.427 -49.712 7.507 1.00 40.20 ? 412 GLU D CB 1 ATOM 5566 C CG . GLU D 1 88 ? 115.846 -49.300 7.190 1.00 44.06 ? 412 GLU D CG 1 ATOM 5567 C CD . GLU D 1 88 ? 116.847 -49.732 8.243 1.00 47.83 ? 412 GLU D CD 1 ATOM 5568 O OE1 . GLU D 1 88 ? 116.431 -50.199 9.342 1.00 48.96 ? 412 GLU D OE1 1 ATOM 5569 O OE2 . GLU D 1 88 ? 118.061 -49.584 7.951 1.00 50.17 ? 412 GLU D OE2 1 ATOM 5570 N N . GLY D 1 89 ? 111.049 -48.886 6.858 1.00 35.21 ? 413 GLY D N 1 ATOM 5571 C CA . GLY D 1 89 ? 109.700 -49.361 6.535 1.00 34.28 ? 413 GLY D CA 1 ATOM 5572 C C . GLY D 1 89 ? 109.079 -50.247 7.592 1.00 32.29 ? 413 GLY D C 1 ATOM 5573 O O . GLY D 1 89 ? 108.385 -51.195 7.271 1.00 32.13 ? 413 GLY D O 1 ATOM 5574 N N . GLU D 1 90 ? 109.319 -49.943 8.860 1.00 31.15 ? 414 GLU D N 1 ATOM 5575 C CA . GLU D 1 90 ? 108.591 -50.615 9.935 1.00 30.53 ? 414 GLU D CA 1 ATOM 5576 C C . GLU D 1 90 ? 107.138 -50.132 9.927 1.00 29.00 ? 414 GLU D C 1 ATOM 5577 O O . GLU D 1 90 ? 106.877 -48.997 9.560 1.00 29.44 ? 414 GLU D O 1 ATOM 5578 C CB . GLU D 1 90 ? 109.284 -50.337 11.276 1.00 30.33 ? 414 GLU D CB 1 ATOM 5579 C CG . GLU D 1 90 ? 108.529 -50.742 12.545 1.00 30.46 ? 414 GLU D CG 1 ATOM 5580 C CD . GLU D 1 90 ? 108.345 -52.246 12.744 1.00 30.34 ? 414 GLU D CD 1 ATOM 5581 O OE1 . GLU D 1 90 ? 107.442 -52.816 12.098 1.00 31.12 ? 414 GLU D OE1 1 ATOM 5582 O OE2 . GLU D 1 90 ? 109.071 -52.856 13.562 1.00 28.03 ? 414 GLU D OE2 1 ATOM 5583 N N . THR D 1 91 ? 106.199 -50.991 10.319 1.00 26.74 ? 415 THR D N 1 ATOM 5584 C CA . THR D 1 91 ? 104.798 -50.603 10.432 1.00 25.05 ? 415 THR D CA 1 ATOM 5585 C C . THR D 1 91 ? 104.408 -50.458 11.909 1.00 27.64 ? 415 THR D C 1 ATOM 5586 O O . THR D 1 91 ? 104.671 -51.361 12.726 1.00 28.10 ? 415 THR D O 1 ATOM 5587 C CB . THR D 1 91 ? 103.895 -51.623 9.753 1.00 24.67 ? 415 THR D CB 1 ATOM 5588 O OG1 . THR D 1 91 ? 104.232 -51.713 8.361 1.00 25.24 ? 415 THR D OG1 1 ATOM 5589 C CG2 . THR D 1 91 ? 102.443 -51.250 9.883 1.00 23.74 ? 415 THR D CG2 1 ATOM 5590 N N . TYR D 1 92 ? 103.805 -49.311 12.230 1.00 27.19 ? 416 TYR D N 1 ATOM 5591 C CA . TYR D 1 92 ? 103.313 -48.985 13.567 1.00 27.82 ? 416 TYR D CA 1 ATOM 5592 C C . TYR D 1 92 ? 101.792 -48.970 13.649 1.00 29.34 ? 416 TYR D C 1 ATOM 5593 O O . TYR D 1 92 ? 101.125 -48.517 12.727 1.00 30.52 ? 416 TYR D O 1 ATOM 5594 C CB . TYR D 1 92 ? 103.827 -47.609 13.979 1.00 26.53 ? 416 TYR D CB 1 ATOM 5595 C CG . TYR D 1 92 ? 105.327 -47.566 14.080 1.00 24.87 ? 416 TYR D CG 1 ATOM 5596 C CD1 . TYR D 1 92 ? 106.088 -47.488 12.940 1.00 24.59 ? 416 TYR D CD1 1 ATOM 5597 C CD2 . TYR D 1 92 ? 105.980 -47.632 15.293 1.00 23.93 ? 416 TYR D CD2 1 ATOM 5598 C CE1 . TYR D 1 92 ? 107.449 -47.452 12.990 1.00 24.71 ? 416 TYR D CE1 1 ATOM 5599 C CE2 . TYR D 1 92 ? 107.366 -47.593 15.333 1.00 24.99 ? 416 TYR D CE2 1 ATOM 5600 C CZ . TYR D 1 92 ? 108.086 -47.514 14.168 1.00 23.62 ? 416 TYR D CZ 1 ATOM 5601 O OH . TYR D 1 92 ? 109.458 -47.471 14.117 1.00 26.19 ? 416 TYR D OH 1 ATOM 5602 N N . GLN D 1 93 ? 101.247 -49.457 14.755 1.00 31.74 ? 417 GLN D N 1 ATOM 5603 C CA . GLN D 1 93 ? 99.802 -49.615 14.878 1.00 35.68 ? 417 GLN D CA 1 ATOM 5604 C C . GLN D 1 93 ? 99.308 -49.056 16.190 1.00 37.30 ? 417 GLN D C 1 ATOM 5605 O O . GLN D 1 93 ? 99.988 -49.108 17.211 1.00 36.51 ? 417 GLN D O 1 ATOM 5606 C CB . GLN D 1 93 ? 99.366 -51.075 14.727 1.00 38.07 ? 417 GLN D CB 1 ATOM 5607 C CG . GLN D 1 93 ? 100.398 -52.074 15.240 1.00 41.08 ? 417 GLN D CG 1 ATOM 5608 C CD . GLN D 1 93 ? 100.112 -53.532 14.868 1.00 41.78 ? 417 GLN D CD 1 ATOM 5609 O OE1 . GLN D 1 93 ? 99.184 -53.827 14.125 1.00 45.32 ? 417 GLN D OE1 1 ATOM 5610 N NE2 . GLN D 1 93 ? 100.911 -54.445 15.400 1.00 40.39 ? 417 GLN D NE2 1 ATOM 5611 N N . CYS D 1 94 ? 98.106 -48.498 16.131 1.00 40.68 ? 418 CYS D N 1 ATOM 5612 C CA . CYS D 1 94 ? 97.481 -47.844 17.260 1.00 41.67 ? 418 CYS D CA 1 ATOM 5613 C C . CYS D 1 94 ? 96.142 -48.520 17.528 1.00 41.52 ? 418 CYS D C 1 ATOM 5614 O O . CYS D 1 94 ? 95.263 -48.491 16.687 1.00 40.27 ? 418 CYS D O 1 ATOM 5615 C CB . CYS D 1 94 ? 97.267 -46.370 16.927 1.00 42.31 ? 418 CYS D CB 1 ATOM 5616 S SG . CYS D 1 94 ? 96.257 -45.476 18.144 1.00 43.66 ? 418 CYS D SG 1 ATOM 5617 N N . ARG D 1 95 ? 95.998 -49.125 18.699 1.00 43.20 ? 419 ARG D N 1 ATOM 5618 C CA . ARG D 1 95 ? 94.799 -49.863 19.061 1.00 44.10 ? 419 ARG D CA 1 ATOM 5619 C C . ARG D 1 95 ? 93.968 -48.996 19.992 1.00 44.99 ? 419 ARG D C 1 ATOM 5620 O O . ARG D 1 95 ? 94.415 -48.664 21.093 1.00 44.83 ? 419 ARG D O 1 ATOM 5621 C CB . ARG D 1 95 ? 95.186 -51.149 19.792 1.00 45.67 ? 419 ARG D CB 1 ATOM 5622 C CG . ARG D 1 95 ? 94.029 -52.059 20.151 1.00 47.33 ? 419 ARG D CG 1 ATOM 5623 C CD . ARG D 1 95 ? 93.938 -53.186 19.150 1.00 49.21 ? 419 ARG D CD 1 ATOM 5624 N NE . ARG D 1 95 ? 92.745 -54.009 19.330 1.00 50.74 ? 419 ARG D NE 1 ATOM 5625 C CZ . ARG D 1 95 ? 92.522 -55.128 18.648 1.00 52.58 ? 419 ARG D CZ 1 ATOM 5626 N NH1 . ARG D 1 95 ? 93.420 -55.549 17.761 1.00 53.09 ? 419 ARG D NH1 1 ATOM 5627 N NH2 . ARG D 1 95 ? 91.411 -55.831 18.848 1.00 53.13 ? 419 ARG D NH2 1 ATOM 5628 N N . VAL D 1 96 ? 92.763 -48.648 19.553 1.00 45.19 ? 420 VAL D N 1 ATOM 5629 C CA . VAL D 1 96 ? 91.913 -47.723 20.291 1.00 46.75 ? 420 VAL D CA 1 ATOM 5630 C C . VAL D 1 96 ? 90.807 -48.462 21.028 1.00 49.41 ? 420 VAL D C 1 ATOM 5631 O O . VAL D 1 96 ? 89.831 -48.869 20.409 1.00 48.25 ? 420 VAL D O 1 ATOM 5632 C CB . VAL D 1 96 ? 91.284 -46.683 19.342 1.00 46.15 ? 420 VAL D CB 1 ATOM 5633 C CG1 . VAL D 1 96 ? 90.176 -45.930 20.033 1.00 45.26 ? 420 VAL D CG1 1 ATOM 5634 C CG2 . VAL D 1 96 ? 92.346 -45.718 18.817 1.00 44.53 ? 420 VAL D CG2 1 ATOM 5635 N N . THR D 1 97 ? 90.981 -48.644 22.339 1.00 53.96 ? 421 THR D N 1 ATOM 5636 C CA . THR D 1 97 ? 89.970 -49.265 23.201 1.00 58.00 ? 421 THR D CA 1 ATOM 5637 C C . THR D 1 97 ? 89.074 -48.223 23.877 1.00 61.95 ? 421 THR D C 1 ATOM 5638 O O . THR D 1 97 ? 89.564 -47.288 24.521 1.00 62.42 ? 421 THR D O 1 ATOM 5639 C CB . THR D 1 97 ? 90.613 -50.111 24.318 1.00 58.38 ? 421 THR D CB 1 ATOM 5640 O OG1 . THR D 1 97 ? 90.883 -51.423 23.821 1.00 59.39 ? 421 THR D OG1 1 ATOM 5641 C CG2 . THR D 1 97 ? 89.686 -50.248 25.523 1.00 59.04 ? 421 THR D CG2 1 ATOM 5642 N N . HIS D 1 98 ? 87.761 -48.404 23.741 1.00 65.65 ? 422 HIS D N 1 ATOM 5643 C CA . HIS D 1 98 ? 86.771 -47.502 24.336 1.00 68.66 ? 422 HIS D CA 1 ATOM 5644 C C . HIS D 1 98 ? 85.756 -48.319 25.154 1.00 70.23 ? 422 HIS D C 1 ATOM 5645 O O . HIS D 1 98 ? 85.392 -49.436 24.765 1.00 69.77 ? 422 HIS D O 1 ATOM 5646 C CB . HIS D 1 98 ? 86.093 -46.670 23.224 1.00 69.79 ? 422 HIS D CB 1 ATOM 5647 C CG . HIS D 1 98 ? 84.990 -45.761 23.693 1.00 70.67 ? 422 HIS D CG 1 ATOM 5648 N ND1 . HIS D 1 98 ? 85.202 -44.449 24.065 1.00 71.31 ? 422 HIS D ND1 1 ATOM 5649 C CD2 . HIS D 1 98 ? 83.658 -45.970 23.825 1.00 70.78 ? 422 HIS D CD2 1 ATOM 5650 C CE1 . HIS D 1 98 ? 84.054 -43.895 24.416 1.00 70.76 ? 422 HIS D CE1 1 ATOM 5651 N NE2 . HIS D 1 98 ? 83.102 -44.799 24.281 1.00 70.52 ? 422 HIS D NE2 1 ATOM 5652 N N . PRO D 1 99 ? 85.307 -47.769 26.300 1.00 72.09 ? 423 PRO D N 1 ATOM 5653 C CA . PRO D 1 99 ? 84.351 -48.449 27.188 1.00 72.70 ? 423 PRO D CA 1 ATOM 5654 C C . PRO D 1 99 ? 83.020 -48.829 26.521 1.00 73.25 ? 423 PRO D C 1 ATOM 5655 O O . PRO D 1 99 ? 82.649 -50.005 26.508 1.00 72.10 ? 423 PRO D O 1 ATOM 5656 C CB . PRO D 1 99 ? 84.123 -47.428 28.313 1.00 72.70 ? 423 PRO D CB 1 ATOM 5657 C CG . PRO D 1 99 ? 84.625 -46.113 27.779 1.00 72.54 ? 423 PRO D CG 1 ATOM 5658 C CD . PRO D 1 99 ? 85.729 -46.463 26.841 1.00 72.27 ? 423 PRO D CD 1 ATOM 5659 N N . HIS D 1 100 ? 82.313 -47.842 25.975 1.00 74.37 ? 424 HIS D N 1 ATOM 5660 C CA . HIS D 1 100 ? 81.068 -48.084 25.251 1.00 75.41 ? 424 HIS D CA 1 ATOM 5661 C C . HIS D 1 100 ? 81.343 -48.570 23.833 1.00 75.66 ? 424 HIS D C 1 ATOM 5662 O O . HIS D 1 100 ? 80.543 -48.337 22.929 1.00 75.57 ? 424 HIS D O 1 ATOM 5663 C CB . HIS D 1 100 ? 80.237 -46.801 25.159 1.00 76.09 ? 424 HIS D CB 1 ATOM 5664 C CG . HIS D 1 100 ? 79.563 -46.410 26.439 1.00 77.00 ? 424 HIS D CG 1 ATOM 5665 N ND1 . HIS D 1 100 ? 79.913 -45.278 27.145 1.00 77.35 ? 424 HIS D ND1 1 ATOM 5666 C CD2 . HIS D 1 100 ? 78.550 -46.986 27.129 1.00 77.46 ? 424 HIS D CD2 1 ATOM 5667 C CE1 . HIS D 1 100 ? 79.149 -45.177 28.218 1.00 77.62 ? 424 HIS D CE1 1 ATOM 5668 N NE2 . HIS D 1 100 ? 78.313 -46.200 28.232 1.00 77.69 ? 424 HIS D NE2 1 ATOM 5669 N N . LEU D 1 101 ? 82.473 -49.238 23.631 1.00 76.28 ? 425 LEU D N 1 ATOM 5670 C CA . LEU D 1 101 ? 82.863 -49.649 22.289 1.00 76.70 ? 425 LEU D CA 1 ATOM 5671 C C . LEU D 1 101 ? 82.789 -51.160 22.131 1.00 76.50 ? 425 LEU D C 1 ATOM 5672 O O . LEU D 1 101 ? 83.322 -51.909 22.953 1.00 76.27 ? 425 LEU D O 1 ATOM 5673 C CB . LEU D 1 101 ? 84.275 -49.164 21.967 1.00 77.24 ? 425 LEU D CB 1 ATOM 5674 C CG . LEU D 1 101 ? 84.657 -49.228 20.486 1.00 77.77 ? 425 LEU D CG 1 ATOM 5675 C CD1 . LEU D 1 101 ? 83.735 -48.339 19.654 1.00 77.90 ? 425 LEU D CD1 1 ATOM 5676 C CD2 . LEU D 1 101 ? 86.118 -48.837 20.291 1.00 77.81 ? 425 LEU D CD2 1 ATOM 5677 N N . PRO D 1 102 ? 82.125 -51.611 21.059 1.00 76.38 ? 426 PRO D N 1 ATOM 5678 C CA . PRO D 1 102 ? 82.027 -53.051 20.884 1.00 75.87 ? 426 PRO D CA 1 ATOM 5679 C C . PRO D 1 102 ? 83.395 -53.621 20.515 1.00 74.51 ? 426 PRO D C 1 ATOM 5680 O O . PRO D 1 102 ? 83.956 -54.406 21.280 1.00 74.21 ? 426 PRO D O 1 ATOM 5681 C CB . PRO D 1 102 ? 80.991 -53.211 19.762 1.00 76.22 ? 426 PRO D CB 1 ATOM 5682 C CG . PRO D 1 102 ? 80.973 -51.900 19.029 1.00 76.44 ? 426 PRO D CG 1 ATOM 5683 C CD . PRO D 1 102 ? 81.513 -50.847 19.955 1.00 76.42 ? 426 PRO D CD 1 ATOM 5684 N N . ARG D 1 103 ? 83.928 -53.203 19.369 1.00 73.15 ? 427 ARG D N 1 ATOM 5685 C CA . ARG D 1 103 ? 85.215 -53.698 18.874 1.00 71.79 ? 427 ARG D CA 1 ATOM 5686 C C . ARG D 1 103 ? 86.193 -52.530 18.686 1.00 69.01 ? 427 ARG D C 1 ATOM 5687 O O . ARG D 1 103 ? 85.795 -51.428 18.302 1.00 68.91 ? 427 ARG D O 1 ATOM 5688 C CB . ARG D 1 103 ? 85.018 -54.488 17.567 1.00 72.64 ? 427 ARG D CB 1 ATOM 5689 C CG . ARG D 1 103 ? 86.218 -55.340 17.139 1.00 73.25 ? 427 ARG D CG 1 ATOM 5690 C CD . ARG D 1 103 ? 86.019 -56.003 15.771 1.00 73.49 ? 427 ARG D CD 1 ATOM 5691 N NE . ARG D 1 103 ? 87.268 -56.574 15.264 1.00 73.63 ? 427 ARG D NE 1 ATOM 5692 C CZ . ARG D 1 103 ? 87.412 -57.158 14.077 1.00 73.37 ? 427 ARG D CZ 1 ATOM 5693 N NH1 . ARG D 1 103 ? 86.378 -57.257 13.253 1.00 73.25 ? 427 ARG D NH1 1 ATOM 5694 N NH2 . ARG D 1 103 ? 88.595 -57.643 13.715 1.00 73.21 ? 427 ARG D NH2 1 ATOM 5695 N N . ALA D 1 104 ? 87.469 -52.782 18.968 1.00 65.51 ? 428 ALA D N 1 ATOM 5696 C CA . ALA D 1 104 ? 88.493 -51.741 18.979 1.00 62.67 ? 428 ALA D CA 1 ATOM 5697 C C . ALA D 1 104 ? 88.752 -51.206 17.572 1.00 59.61 ? 428 ALA D C 1 ATOM 5698 O O . ALA D 1 104 ? 88.433 -51.878 16.593 1.00 59.33 ? 428 ALA D O 1 ATOM 5699 C CB . ALA D 1 104 ? 89.771 -52.305 19.570 1.00 62.91 ? 428 ALA D CB 1 ATOM 5700 N N . LEU D 1 105 ? 89.321 -50.008 17.463 1.00 55.83 ? 429 LEU D N 1 ATOM 5701 C CA . LEU D 1 105 ? 89.762 -49.502 16.166 1.00 53.91 ? 429 LEU D CA 1 ATOM 5702 C C . LEU D 1 105 ? 91.267 -49.673 16.006 1.00 52.47 ? 429 LEU D C 1 ATOM 5703 O O . LEU D 1 105 ? 92.035 -49.287 16.894 1.00 51.44 ? 429 LEU D O 1 ATOM 5704 C CB . LEU D 1 105 ? 89.398 -48.029 15.985 1.00 54.11 ? 429 LEU D CB 1 ATOM 5705 C CG . LEU D 1 105 ? 87.933 -47.714 15.652 1.00 54.68 ? 429 LEU D CG 1 ATOM 5706 C CD1 . LEU D 1 105 ? 87.533 -46.336 16.206 1.00 53.81 ? 429 LEU D CD1 1 ATOM 5707 C CD2 . LEU D 1 105 ? 87.652 -47.836 14.141 1.00 54.18 ? 429 LEU D CD2 1 ATOM 5708 N N . MET D 1 106 ? 91.679 -50.262 14.883 1.00 50.38 ? 430 MET D N 1 ATOM 5709 C CA . MET D 1 106 ? 93.088 -50.339 14.532 1.00 49.80 ? 430 MET D CA 1 ATOM 5710 C C . MET D 1 106 ? 93.404 -49.393 13.390 1.00 47.92 ? 430 MET D C 1 ATOM 5711 O O . MET D 1 106 ? 92.640 -49.235 12.437 1.00 47.89 ? 430 MET D O 1 ATOM 5712 C CB . MET D 1 106 ? 93.499 -51.755 14.152 1.00 51.83 ? 430 MET D CB 1 ATOM 5713 C CG . MET D 1 106 ? 93.449 -52.729 15.318 1.00 53.92 ? 430 MET D CG 1 ATOM 5714 S SD . MET D 1 106 ? 91.780 -53.387 15.531 1.00 56.71 ? 430 MET D SD 1 ATOM 5715 C CE . MET D 1 106 ? 91.842 -54.778 14.379 1.00 55.38 ? 430 MET D CE 1 ATOM 5716 N N . ARG D 1 107 ? 94.547 -48.743 13.510 1.00 45.15 ? 431 ARG D N 1 ATOM 5717 C CA . ARG D 1 107 ? 95.046 -47.892 12.464 1.00 43.85 ? 431 ARG D CA 1 ATOM 5718 C C . ARG D 1 107 ? 96.517 -48.223 12.400 1.00 42.42 ? 431 ARG D C 1 ATOM 5719 O O . ARG D 1 107 ? 97.161 -48.442 13.429 1.00 43.20 ? 431 ARG D O 1 ATOM 5720 C CB . ARG D 1 107 ? 94.855 -46.420 12.830 1.00 44.62 ? 431 ARG D CB 1 ATOM 5721 C CG . ARG D 1 107 ? 93.410 -45.960 12.819 1.00 46.39 ? 431 ARG D CG 1 ATOM 5722 C CD . ARG D 1 107 ? 92.774 -46.050 11.411 1.00 47.21 ? 431 ARG D CD 1 ATOM 5723 N NE . ARG D 1 107 ? 91.467 -45.393 11.350 1.00 48.03 ? 431 ARG D NE 1 ATOM 5724 C CZ . ARG D 1 107 ? 90.308 -45.983 11.634 1.00 49.02 ? 431 ARG D CZ 1 ATOM 5725 N NH1 . ARG D 1 107 ? 90.270 -47.261 11.999 1.00 49.44 ? 431 ARG D NH1 1 ATOM 5726 N NH2 . ARG D 1 107 ? 89.178 -45.292 11.550 1.00 49.61 ? 431 ARG D NH2 1 ATOM 5727 N N . SER D 1 108 ? 97.058 -48.269 11.195 1.00 39.18 ? 432 SER D N 1 ATOM 5728 C CA . SER D 1 108 ? 98.471 -48.509 11.054 1.00 37.80 ? 432 SER D CA 1 ATOM 5729 C C . SER D 1 108 ? 99.084 -47.468 10.116 1.00 36.16 ? 432 SER D C 1 ATOM 5730 O O . SER D 1 108 ? 98.374 -46.775 9.388 1.00 36.34 ? 432 SER D O 1 ATOM 5731 C CB . SER D 1 108 ? 98.695 -49.932 10.556 1.00 38.36 ? 432 SER D CB 1 ATOM 5732 O OG . SER D 1 108 ? 98.076 -50.113 9.308 1.00 39.64 ? 432 SER D OG 1 ATOM 5733 N N . THR D 1 109 ? 100.405 -47.343 10.151 1.00 32.15 ? 433 THR D N 1 ATOM 5734 C CA . THR D 1 109 ? 101.094 -46.426 9.269 1.00 30.26 ? 433 THR D CA 1 ATOM 5735 C C . THR D 1 109 ? 102.519 -46.877 9.045 1.00 27.55 ? 433 THR D C 1 ATOM 5736 O O . THR D 1 109 ? 103.136 -47.438 9.948 1.00 27.07 ? 433 THR D O 1 ATOM 5737 C CB . THR D 1 109 ? 101.150 -44.986 9.851 1.00 32.10 ? 433 THR D CB 1 ATOM 5738 O OG1 . THR D 1 109 ? 101.770 -44.108 8.903 1.00 33.79 ? 433 THR D OG1 1 ATOM 5739 C CG2 . THR D 1 109 ? 101.964 -44.942 11.120 1.00 32.38 ? 433 THR D CG2 1 ATOM 5740 N N . THR D 1 110 ? 103.041 -46.603 7.854 1.00 24.84 ? 434 THR D N 1 ATOM 5741 C CA . THR D 1 110 ? 104.389 -46.988 7.492 1.00 26.09 ? 434 THR D CA 1 ATOM 5742 C C . THR D 1 110 ? 104.848 -45.969 6.459 1.00 29.27 ? 434 THR D C 1 ATOM 5743 O O . THR D 1 110 ? 104.077 -45.113 6.055 1.00 29.59 ? 434 THR D O 1 ATOM 5744 C CB . THR D 1 110 ? 104.435 -48.447 6.926 1.00 24.68 ? 434 THR D CB 1 ATOM 5745 O OG1 . THR D 1 110 ? 105.787 -48.921 6.854 1.00 23.95 ? 434 THR D OG1 1 ATOM 5746 C CG2 . THR D 1 110 ? 103.817 -48.530 5.550 1.00 23.29 ? 434 THR D CG2 1 ATOM 5747 N N . LYS D 1 111 ? 106.093 -46.036 6.020 1.00 33.41 ? 435 LYS D N 1 ATOM 5748 C CA . LYS D 1 111 ? 106.557 -44.999 5.131 1.00 38.54 ? 435 LYS D CA 1 ATOM 5749 C C . LYS D 1 111 ? 106.023 -45.307 3.742 1.00 41.61 ? 435 LYS D C 1 ATOM 5750 O O . LYS D 1 111 ? 106.081 -46.461 3.306 1.00 41.46 ? 435 LYS D O 1 ATOM 5751 C CB . LYS D 1 111 ? 108.084 -44.872 5.179 1.00 40.06 ? 435 LYS D CB 1 ATOM 5752 C CG . LYS D 1 111 ? 108.858 -45.661 4.146 1.00 42.15 ? 435 LYS D CG 1 ATOM 5753 C CD . LYS D 1 111 ? 110.178 -44.950 3.832 1.00 43.05 ? 435 LYS D CD 1 ATOM 5754 C CE . LYS D 1 111 ? 110.782 -45.467 2.537 1.00 43.39 ? 435 LYS D CE 1 ATOM 5755 N NZ . LYS D 1 111 ? 111.986 -44.676 2.163 1.00 44.50 ? 435 LYS D NZ 1 ATOM 5756 N N . THR D 1 112 ? 105.492 -44.280 3.073 1.00 45.44 ? 436 THR D N 1 ATOM 5757 C CA . THR D 1 112 ? 104.877 -44.426 1.749 1.00 47.81 ? 436 THR D CA 1 ATOM 5758 C C . THR D 1 112 ? 105.958 -44.682 0.734 1.00 48.22 ? 436 THR D C 1 ATOM 5759 O O . THR D 1 112 ? 107.006 -44.068 0.800 1.00 50.72 ? 436 THR D O 1 ATOM 5760 C CB . THR D 1 112 ? 104.121 -43.168 1.281 1.00 49.22 ? 436 THR D CB 1 ATOM 5761 O OG1 . THR D 1 112 ? 103.156 -42.781 2.269 1.00 50.74 ? 436 THR D OG1 1 ATOM 5762 C CG2 . THR D 1 112 ? 103.400 -43.422 -0.061 1.00 49.74 ? 436 THR D CG2 1 ATOM 5763 N N . SER D 1 113 ? 105.691 -45.606 -0.183 1.00 49.06 ? 437 SER D N 1 ATOM 5764 C CA . SER D 1 113 ? 106.583 -45.907 -1.291 1.00 49.17 ? 437 SER D CA 1 ATOM 5765 C C . SER D 1 113 ? 106.026 -45.332 -2.599 1.00 48.53 ? 437 SER D C 1 ATOM 5766 O O . SER D 1 113 ? 105.117 -44.485 -2.602 1.00 48.50 ? 437 SER D O 1 ATOM 5767 C CB . SER D 1 113 ? 106.761 -47.424 -1.420 1.00 50.26 ? 437 SER D CB 1 ATOM 5768 O OG . SER D 1 113 ? 107.777 -47.754 -2.355 1.00 50.88 ? 437 SER D OG 1 ATOM 5769 N N . GLY D 1 114 ? 106.580 -45.793 -3.716 1.00 46.28 ? 438 GLY D N 1 ATOM 5770 C CA . GLY D 1 114 ? 106.167 -45.280 -5.009 1.00 44.18 ? 438 GLY D CA 1 ATOM 5771 C C . GLY D 1 114 ? 107.191 -44.321 -5.571 1.00 42.24 ? 438 GLY D C 1 ATOM 5772 O O . GLY D 1 114 ? 108.282 -44.166 -5.024 1.00 41.97 ? 438 GLY D O 1 ATOM 5773 N N . PRO D 1 115 ? 106.837 -43.669 -6.677 1.00 40.43 ? 439 PRO D N 1 ATOM 5774 C CA . PRO D 1 115 ? 107.698 -42.710 -7.351 1.00 39.46 ? 439 PRO D CA 1 ATOM 5775 C C . PRO D 1 115 ? 107.978 -41.459 -6.502 1.00 37.37 ? 439 PRO D C 1 ATOM 5776 O O . PRO D 1 115 ? 107.108 -40.996 -5.773 1.00 36.72 ? 439 PRO D O 1 ATOM 5777 C CB . PRO D 1 115 ? 106.905 -42.364 -8.621 1.00 40.20 ? 439 PRO D CB 1 ATOM 5778 C CG . PRO D 1 115 ? 105.796 -43.397 -8.719 1.00 40.28 ? 439 PRO D CG 1 ATOM 5779 C CD . PRO D 1 115 ? 105.517 -43.791 -7.319 1.00 40.54 ? 439 PRO D CD 1 ATOM 5780 N N . ARG D 1 116 ? 109.201 -40.949 -6.597 1.00 37.17 ? 440 ARG D N 1 ATOM 5781 C CA . ARG D 1 116 ? 109.640 -39.736 -5.913 1.00 37.17 ? 440 ARG D CA 1 ATOM 5782 C C . ARG D 1 116 ? 109.818 -38.599 -6.915 1.00 33.97 ? 440 ARG D C 1 ATOM 5783 O O . ARG D 1 116 ? 110.457 -38.778 -7.949 1.00 31.57 ? 440 ARG D O 1 ATOM 5784 C CB . ARG D 1 116 ? 110.999 -39.928 -5.227 1.00 40.36 ? 440 ARG D CB 1 ATOM 5785 C CG . ARG D 1 116 ? 111.161 -41.163 -4.355 1.00 44.11 ? 440 ARG D CG 1 ATOM 5786 C CD . ARG D 1 116 ? 110.176 -41.249 -3.205 1.00 46.30 ? 440 ARG D CD 1 ATOM 5787 N NE . ARG D 1 116 ? 110.230 -42.561 -2.558 1.00 49.52 ? 440 ARG D NE 1 ATOM 5788 C CZ . ARG D 1 116 ? 109.653 -42.865 -1.392 1.00 52.04 ? 440 ARG D CZ 1 ATOM 5789 N NH1 . ARG D 1 116 ? 108.971 -41.949 -0.708 1.00 52.25 ? 440 ARG D NH1 1 ATOM 5790 N NH2 . ARG D 1 116 ? 109.773 -44.097 -0.897 1.00 53.16 ? 440 ARG D NH2 1 ATOM 5791 N N . ALA D 1 117 ? 109.262 -37.434 -6.590 1.00 31.42 ? 441 ALA D N 1 ATOM 5792 C CA . ALA D 1 117 ? 109.356 -36.243 -7.435 1.00 30.28 ? 441 ALA D CA 1 ATOM 5793 C C . ALA D 1 117 ? 109.460 -35.032 -6.539 1.00 29.22 ? 441 ALA D C 1 ATOM 5794 O O . ALA D 1 117 ? 108.642 -34.841 -5.666 1.00 30.40 ? 441 ALA D O 1 ATOM 5795 C CB . ALA D 1 117 ? 108.160 -36.110 -8.343 1.00 26.78 ? 441 ALA D CB 1 ATOM 5796 N N . ALA D 1 118 ? 110.486 -34.226 -6.763 1.00 30.03 ? 442 ALA D N 1 ATOM 5797 C CA . ALA D 1 118 ? 110.798 -33.093 -5.917 1.00 29.40 ? 442 ALA D CA 1 ATOM 5798 C C . ALA D 1 118 ? 109.714 -32.042 -6.078 1.00 29.40 ? 442 ALA D C 1 ATOM 5799 O O . ALA D 1 118 ? 109.109 -31.954 -7.138 1.00 30.10 ? 442 ALA D O 1 ATOM 5800 C CB . ALA D 1 118 ? 112.144 -32.507 -6.324 1.00 29.20 ? 442 ALA D CB 1 ATOM 5801 N N . PRO D 1 119 ? 109.474 -31.238 -5.029 1.00 29.29 ? 443 PRO D N 1 ATOM 5802 C CA . PRO D 1 119 ? 108.500 -30.173 -5.144 1.00 29.04 ? 443 PRO D CA 1 ATOM 5803 C C . PRO D 1 119 ? 109.048 -29.006 -5.943 1.00 29.26 ? 443 PRO D C 1 ATOM 5804 O O . PRO D 1 119 ? 110.251 -28.728 -5.913 1.00 28.33 ? 443 PRO D O 1 ATOM 5805 C CB . PRO D 1 119 ? 108.272 -29.728 -3.687 1.00 27.50 ? 443 PRO D CB 1 ATOM 5806 C CG . PRO D 1 119 ? 109.098 -30.570 -2.847 1.00 27.58 ? 443 PRO D CG 1 ATOM 5807 C CD . PRO D 1 119 ? 110.133 -31.199 -3.712 1.00 28.84 ? 443 PRO D CD 1 ATOM 5808 N N . GLU D 1 120 ? 108.148 -28.331 -6.641 1.00 29.25 ? 444 GLU D N 1 ATOM 5809 C CA . GLU D 1 120 ? 108.458 -27.029 -7.180 1.00 30.48 ? 444 GLU D CA 1 ATOM 5810 C C . GLU D 1 120 ? 107.795 -25.962 -6.320 1.00 28.85 ? 444 GLU D C 1 ATOM 5811 O O . GLU D 1 120 ? 106.594 -25.990 -6.084 1.00 30.06 ? 444 GLU D O 1 ATOM 5812 C CB . GLU D 1 120 ? 108.025 -26.944 -8.656 1.00 34.08 ? 444 GLU D CB 1 ATOM 5813 C CG . GLU D 1 120 ? 107.036 -28.025 -9.083 1.00 35.86 ? 444 GLU D CG 1 ATOM 5814 C CD . GLU D 1 120 ? 106.668 -27.995 -10.562 1.00 36.76 ? 444 GLU D CD 1 ATOM 5815 O OE1 . GLU D 1 120 ? 106.328 -26.916 -11.120 1.00 35.94 ? 444 GLU D OE1 1 ATOM 5816 O OE2 . GLU D 1 120 ? 106.684 -29.094 -11.148 1.00 37.13 ? 444 GLU D OE2 1 ATOM 5817 N N . VAL D 1 121 ? 108.603 -25.028 -5.842 1.00 27.50 ? 445 VAL D N 1 ATOM 5818 C CA . VAL D 1 121 ? 108.148 -23.954 -4.985 1.00 26.89 ? 445 VAL D CA 1 ATOM 5819 C C . VAL D 1 121 ? 108.083 -22.602 -5.732 1.00 27.84 ? 445 VAL D C 1 ATOM 5820 O O . VAL D 1 121 ? 109.008 -22.193 -6.446 1.00 28.42 ? 445 VAL D O 1 ATOM 5821 C CB . VAL D 1 121 ? 109.086 -23.847 -3.750 1.00 26.26 ? 445 VAL D CB 1 ATOM 5822 C CG1 . VAL D 1 121 ? 108.537 -22.919 -2.700 1.00 22.62 ? 445 VAL D CG1 1 ATOM 5823 C CG2 . VAL D 1 121 ? 109.288 -25.229 -3.130 1.00 26.92 ? 445 VAL D CG2 1 ATOM 5824 N N . TYR D 1 122 ? 106.965 -21.911 -5.551 1.00 26.72 ? 446 TYR D N 1 ATOM 5825 C CA . TYR D 1 122 ? 106.754 -20.617 -6.125 1.00 24.96 ? 446 TYR D CA 1 ATOM 5826 C C . TYR D 1 122 ? 106.164 -19.734 -5.042 1.00 24.92 ? 446 TYR D C 1 ATOM 5827 O O . TYR D 1 122 ? 105.242 -20.152 -4.329 1.00 26.79 ? 446 TYR D O 1 ATOM 5828 C CB . TYR D 1 122 ? 105.743 -20.718 -7.236 1.00 24.82 ? 446 TYR D CB 1 ATOM 5829 C CG . TYR D 1 122 ? 106.025 -21.748 -8.281 1.00 27.72 ? 446 TYR D CG 1 ATOM 5830 C CD1 . TYR D 1 122 ? 105.459 -23.013 -8.198 1.00 28.91 ? 446 TYR D CD1 1 ATOM 5831 C CD2 . TYR D 1 122 ? 106.839 -21.468 -9.366 1.00 27.69 ? 446 TYR D CD2 1 ATOM 5832 C CE1 . TYR D 1 122 ? 105.687 -23.966 -9.162 1.00 28.96 ? 446 TYR D CE1 1 ATOM 5833 C CE2 . TYR D 1 122 ? 107.075 -22.422 -10.343 1.00 28.64 ? 446 TYR D CE2 1 ATOM 5834 C CZ . TYR D 1 122 ? 106.485 -23.672 -10.233 1.00 29.90 ? 446 TYR D CZ 1 ATOM 5835 O OH . TYR D 1 122 ? 106.689 -24.664 -11.176 1.00 31.38 ? 446 TYR D OH 1 ATOM 5836 N N . ALA D 1 123 ? 106.678 -18.521 -4.911 1.00 22.54 ? 447 ALA D N 1 ATOM 5837 C CA . ALA D 1 123 ? 106.228 -17.662 -3.844 1.00 24.98 ? 447 ALA D CA 1 ATOM 5838 C C . ALA D 1 123 ? 105.819 -16.386 -4.488 1.00 26.22 ? 447 ALA D C 1 ATOM 5839 O O . ALA D 1 123 ? 106.396 -15.998 -5.508 1.00 27.03 ? 447 ALA D O 1 ATOM 5840 C CB . ALA D 1 123 ? 107.330 -17.412 -2.818 1.00 26.02 ? 447 ALA D CB 1 ATOM 5841 N N . PHE D 1 124 ? 104.813 -15.741 -3.909 1.00 25.70 ? 448 PHE D N 1 ATOM 5842 C CA . PHE D 1 124 ? 104.315 -14.502 -4.483 1.00 24.87 ? 448 PHE D CA 1 ATOM 5843 C C . PHE D 1 124 ? 103.927 -13.544 -3.374 1.00 24.19 ? 448 PHE D C 1 ATOM 5844 O O . PHE D 1 124 ? 103.629 -13.972 -2.253 1.00 23.32 ? 448 PHE D O 1 ATOM 5845 C CB . PHE D 1 124 ? 103.065 -14.738 -5.320 1.00 26.46 ? 448 PHE D CB 1 ATOM 5846 C CG . PHE D 1 124 ? 103.151 -15.889 -6.280 1.00 29.09 ? 448 PHE D CG 1 ATOM 5847 C CD1 . PHE D 1 124 ? 102.650 -17.129 -5.918 1.00 30.02 ? 448 PHE D CD1 1 ATOM 5848 C CD2 . PHE D 1 124 ? 103.662 -15.719 -7.577 1.00 30.78 ? 448 PHE D CD2 1 ATOM 5849 C CE1 . PHE D 1 124 ? 102.712 -18.195 -6.814 1.00 31.27 ? 448 PHE D CE1 1 ATOM 5850 C CE2 . PHE D 1 124 ? 103.717 -16.773 -8.481 1.00 30.22 ? 448 PHE D CE2 1 ATOM 5851 C CZ . PHE D 1 124 ? 103.249 -18.014 -8.093 1.00 30.60 ? 448 PHE D CZ 1 ATOM 5852 N N . ALA D 1 125 ? 103.917 -12.263 -3.731 1.00 23.37 ? 449 ALA D N 1 ATOM 5853 C CA . ALA D 1 125 ? 103.516 -11.169 -2.867 1.00 24.19 ? 449 ALA D CA 1 ATOM 5854 C C . ALA D 1 125 ? 102.295 -10.487 -3.471 1.00 24.46 ? 449 ALA D C 1 ATOM 5855 O O . ALA D 1 125 ? 102.292 -10.138 -4.632 1.00 26.99 ? 449 ALA D O 1 ATOM 5856 C CB . ALA D 1 125 ? 104.647 -10.173 -2.724 1.00 22.98 ? 449 ALA D CB 1 ATOM 5857 N N . THR D 1 126 ? 101.241 -10.312 -2.690 1.00 24.10 ? 450 THR D N 1 ATOM 5858 C CA . THR D 1 126 ? 100.136 -9.491 -3.113 1.00 24.52 ? 450 THR D CA 1 ATOM 5859 C C . THR D 1 126 ? 100.564 -8.022 -3.125 1.00 25.36 ? 450 THR D C 1 ATOM 5860 O O . THR D 1 126 ? 101.354 -7.615 -2.274 1.00 24.03 ? 450 THR D O 1 ATOM 5861 C CB . THR D 1 126 ? 98.997 -9.621 -2.122 1.00 23.61 ? 450 THR D CB 1 ATOM 5862 O OG1 . THR D 1 126 ? 99.472 -9.163 -0.857 1.00 21.96 ? 450 THR D OG1 1 ATOM 5863 C CG2 . THR D 1 126 ? 98.526 -11.083 -2.029 1.00 22.43 ? 450 THR D CG2 1 ATOM 5864 N N . PRO D 1 127 ? 100.039 -7.226 -4.075 1.00 27.05 ? 451 PRO D N 1 ATOM 5865 C CA . PRO D 1 127 ? 100.266 -5.785 -4.087 1.00 30.02 ? 451 PRO D CA 1 ATOM 5866 C C . PRO D 1 127 ? 99.423 -5.110 -3.006 1.00 34.11 ? 451 PRO D C 1 ATOM 5867 O O . PRO D 1 127 ? 98.576 -5.755 -2.379 1.00 35.54 ? 451 PRO D O 1 ATOM 5868 C CB . PRO D 1 127 ? 99.834 -5.372 -5.493 1.00 28.66 ? 451 PRO D CB 1 ATOM 5869 C CG . PRO D 1 127 ? 98.779 -6.338 -5.855 1.00 28.42 ? 451 PRO D CG 1 ATOM 5870 C CD . PRO D 1 127 ? 99.145 -7.642 -5.169 1.00 28.14 ? 451 PRO D CD 1 ATOM 5871 N N . GLU D 1 128 ? 99.665 -3.833 -2.758 1.00 40.08 ? 452 GLU D N 1 ATOM 5872 C CA . GLU D 1 128 ? 98.880 -3.106 -1.752 1.00 44.72 ? 452 GLU D CA 1 ATOM 5873 C C . GLU D 1 128 ? 97.394 -3.109 -2.119 1.00 47.45 ? 452 GLU D C 1 ATOM 5874 O O . GLU D 1 128 ? 97.030 -2.610 -3.188 1.00 49.31 ? 452 GLU D O 1 ATOM 5875 C CB . GLU D 1 128 ? 99.374 -1.662 -1.613 1.00 44.90 ? 452 GLU D CB 1 ATOM 5876 C CG . GLU D 1 128 ? 98.560 -0.835 -0.612 1.00 46.15 ? 452 GLU D CG 1 ATOM 5877 C CD . GLU D 1 128 ? 99.152 0.544 -0.338 1.00 46.97 ? 452 GLU D CD 1 ATOM 5878 O OE1 . GLU D 1 128 ? 100.388 0.638 -0.115 1.00 47.80 ? 452 GLU D OE1 1 ATOM 5879 O OE2 . GLU D 1 128 ? 98.371 1.528 -0.340 1.00 47.01 ? 452 GLU D OE2 1 ATOM 5880 N N . TRP D 1 129 ? 96.546 -3.659 -1.249 1.00 49.67 ? 453 TRP D N 1 ATOM 5881 C CA . TRP D 1 129 ? 95.103 -3.614 -1.473 1.00 51.89 ? 453 TRP D CA 1 ATOM 5882 C C . TRP D 1 129 ? 94.525 -2.359 -0.845 1.00 54.15 ? 453 TRP D C 1 ATOM 5883 O O . TRP D 1 129 ? 94.932 -1.984 0.258 1.00 54.84 ? 453 TRP D O 1 ATOM 5884 C CB . TRP D 1 129 ? 94.400 -4.853 -0.907 1.00 51.97 ? 453 TRP D CB 1 ATOM 5885 C CG . TRP D 1 129 ? 92.936 -4.963 -1.316 1.00 52.02 ? 453 TRP D CG 1 ATOM 5886 C CD1 . TRP D 1 129 ? 91.853 -4.490 -0.619 1.00 51.81 ? 453 TRP D CD1 1 ATOM 5887 C CD2 . TRP D 1 129 ? 92.405 -5.570 -2.511 1.00 51.38 ? 453 TRP D CD2 1 ATOM 5888 N NE1 . TRP D 1 129 ? 90.689 -4.765 -1.303 1.00 51.49 ? 453 TRP D NE1 1 ATOM 5889 C CE2 . TRP D 1 129 ? 90.997 -5.425 -2.466 1.00 51.41 ? 453 TRP D CE2 1 ATOM 5890 C CE3 . TRP D 1 129 ? 92.978 -6.218 -3.615 1.00 51.10 ? 453 TRP D CE3 1 ATOM 5891 C CZ2 . TRP D 1 129 ? 90.157 -5.914 -3.479 1.00 50.97 ? 453 TRP D CZ2 1 ATOM 5892 C CZ3 . TRP D 1 129 ? 92.131 -6.702 -4.631 1.00 50.47 ? 453 TRP D CZ3 1 ATOM 5893 C CH2 . TRP D 1 129 ? 90.741 -6.550 -4.546 1.00 50.28 ? 453 TRP D CH2 1 ATOM 5894 N N . PRO D 1 130 ? 93.585 -1.702 -1.548 1.00 57.38 ? 454 PRO D N 1 ATOM 5895 C CA . PRO D 1 130 ? 92.948 -0.536 -0.947 1.00 58.71 ? 454 PRO D CA 1 ATOM 5896 C C . PRO D 1 130 ? 92.354 -0.990 0.370 1.00 59.87 ? 454 PRO D C 1 ATOM 5897 O O . PRO D 1 130 ? 91.554 -1.924 0.416 1.00 59.97 ? 454 PRO D O 1 ATOM 5898 C CB . PRO D 1 130 ? 91.848 -0.148 -1.946 1.00 58.88 ? 454 PRO D CB 1 ATOM 5899 C CG . PRO D 1 130 ? 91.674 -1.326 -2.851 1.00 58.79 ? 454 PRO D CG 1 ATOM 5900 C CD . PRO D 1 130 ? 93.016 -2.024 -2.869 1.00 58.41 ? 454 PRO D CD 1 ATOM 5901 N N . GLY D 1 131 ? 92.773 -0.355 1.450 1.00 60.96 ? 455 GLY D N 1 ATOM 5902 C CA . GLY D 1 131 ? 92.343 -0.811 2.755 1.00 62.06 ? 455 GLY D CA 1 ATOM 5903 C C . GLY D 1 131 ? 93.474 -0.512 3.699 1.00 62.75 ? 455 GLY D C 1 ATOM 5904 O O . GLY D 1 131 ? 93.756 0.652 3.985 1.00 64.39 ? 455 GLY D O 1 ATOM 5905 N N . SER D 1 132 ? 94.143 -1.549 4.181 1.00 62.50 ? 456 SER D N 1 ATOM 5906 C CA . SER D 1 132 ? 95.277 -1.299 5.055 1.00 62.71 ? 456 SER D CA 1 ATOM 5907 C C . SER D 1 132 ? 96.578 -1.514 4.281 1.00 60.77 ? 456 SER D C 1 ATOM 5908 O O . SER D 1 132 ? 96.759 -2.523 3.604 1.00 60.03 ? 456 SER D O 1 ATOM 5909 C CB . SER D 1 132 ? 95.187 -2.112 6.359 1.00 63.40 ? 456 SER D CB 1 ATOM 5910 O OG . SER D 1 132 ? 94.594 -3.391 6.153 1.00 64.73 ? 456 SER D OG 1 ATOM 5911 N N . ARG D 1 133 ? 97.469 -0.532 4.377 1.00 58.81 ? 457 ARG D N 1 ATOM 5912 C CA . ARG D 1 133 ? 98.704 -0.534 3.612 1.00 57.12 ? 457 ARG D CA 1 ATOM 5913 C C . ARG D 1 133 ? 99.901 -0.803 4.507 1.00 54.03 ? 457 ARG D C 1 ATOM 5914 O O . ARG D 1 133 ? 101.046 -0.629 4.093 1.00 51.95 ? 457 ARG D O 1 ATOM 5915 C CB . ARG D 1 133 ? 98.894 0.813 2.927 1.00 58.95 ? 457 ARG D CB 1 ATOM 5916 C CG . ARG D 1 133 ? 99.097 1.980 3.888 1.00 60.38 ? 457 ARG D CG 1 ATOM 5917 C CD . ARG D 1 133 ? 99.992 3.035 3.247 1.00 61.71 ? 457 ARG D CD 1 ATOM 5918 N NE . ARG D 1 133 ? 100.573 3.956 4.223 1.00 62.75 ? 457 ARG D NE 1 ATOM 5919 C CZ . ARG D 1 133 ? 101.730 4.596 4.059 1.00 63.53 ? 457 ARG D CZ 1 ATOM 5920 N NH1 . ARG D 1 133 ? 102.453 4.425 2.955 1.00 63.37 ? 457 ARG D NH1 1 ATOM 5921 N NH2 . ARG D 1 133 ? 102.173 5.412 5.008 1.00 64.27 ? 457 ARG D NH2 1 ATOM 5922 N N . ASP D 1 134 ? 99.634 -1.229 5.735 1.00 51.48 ? 458 ASP D N 1 ATOM 5923 C CA . ASP D 1 134 ? 100.702 -1.696 6.609 1.00 50.47 ? 458 ASP D CA 1 ATOM 5924 C C . ASP D 1 134 ? 100.732 -3.237 6.680 1.00 49.61 ? 458 ASP D C 1 ATOM 5925 O O . ASP D 1 134 ? 101.407 -3.837 7.524 1.00 48.01 ? 458 ASP D O 1 ATOM 5926 C CB . ASP D 1 134 ? 100.561 -1.044 7.988 1.00 50.07 ? 458 ASP D CB 1 ATOM 5927 C CG . ASP D 1 134 ? 100.856 0.455 7.959 1.00 49.78 ? 458 ASP D CG 1 ATOM 5928 O OD1 . ASP D 1 134 ? 101.579 0.903 7.044 1.00 49.17 ? 458 ASP D OD1 1 ATOM 5929 O OD2 . ASP D 1 134 ? 100.369 1.191 8.845 1.00 49.89 ? 458 ASP D OD2 1 ATOM 5930 N N . LYS D 1 135 ? 100.000 -3.873 5.772 1.00 47.75 ? 459 LYS D N 1 ATOM 5931 C CA . LYS D 1 135 ? 99.951 -5.321 5.706 1.00 47.25 ? 459 LYS D CA 1 ATOM 5932 C C . LYS D 1 135 ? 100.112 -5.802 4.273 1.00 44.31 ? 459 LYS D C 1 ATOM 5933 O O . LYS D 1 135 ? 99.714 -5.156 3.309 1.00 43.72 ? 459 LYS D O 1 ATOM 5934 C CB . LYS D 1 135 ? 98.644 -5.851 6.298 1.00 49.06 ? 459 LYS D CB 1 ATOM 5935 C CG . LYS D 1 135 ? 98.572 -5.632 7.804 1.00 51.74 ? 459 LYS D CG 1 ATOM 5936 C CD . LYS D 1 135 ? 97.294 -6.182 8.434 1.00 53.99 ? 459 LYS D CD 1 ATOM 5937 C CE . LYS D 1 135 ? 97.379 -6.146 9.971 1.00 55.84 ? 459 LYS D CE 1 ATOM 5938 N NZ . LYS D 1 135 ? 96.563 -7.217 10.639 1.00 56.47 ? 459 LYS D NZ 1 ATOM 5939 N N . ARG D 1 136 ? 100.721 -6.962 4.138 1.00 40.62 ? 460 ARG D N 1 ATOM 5940 C CA . ARG D 1 136 ? 100.784 -7.590 2.849 1.00 37.56 ? 460 ARG D CA 1 ATOM 5941 C C . ARG D 1 136 ? 100.594 -9.087 3.035 1.00 33.73 ? 460 ARG D C 1 ATOM 5942 O O . ARG D 1 136 ? 100.801 -9.617 4.112 1.00 32.64 ? 460 ARG D O 1 ATOM 5943 C CB . ARG D 1 136 ? 102.128 -7.269 2.222 1.00 38.80 ? 460 ARG D CB 1 ATOM 5944 C CG . ARG D 1 136 ? 102.009 -6.823 0.801 1.00 41.04 ? 460 ARG D CG 1 ATOM 5945 C CD . ARG D 1 136 ? 101.493 -5.401 0.686 1.00 41.81 ? 460 ARG D CD 1 ATOM 5946 N NE . ARG D 1 136 ? 102.107 -4.784 -0.481 1.00 43.26 ? 460 ARG D NE 1 ATOM 5947 C CZ . ARG D 1 136 ? 102.522 -3.521 -0.550 1.00 45.35 ? 460 ARG D CZ 1 ATOM 5948 N NH1 . ARG D 1 136 ? 102.376 -2.691 0.481 1.00 45.24 ? 460 ARG D NH1 1 ATOM 5949 N NH2 . ARG D 1 136 ? 103.079 -3.084 -1.676 1.00 46.87 ? 460 ARG D NH2 1 ATOM 5950 N N . THR D 1 137 ? 100.193 -9.785 1.990 1.00 31.64 ? 461 THR D N 1 ATOM 5951 C CA . THR D 1 137 ? 100.009 -11.223 2.095 1.00 28.70 ? 461 THR D CA 1 ATOM 5952 C C . THR D 1 137 ? 100.940 -11.923 1.109 1.00 28.60 ? 461 THR D C 1 ATOM 5953 O O . THR D 1 137 ? 100.946 -11.622 -0.086 1.00 28.66 ? 461 THR D O 1 ATOM 5954 C CB . THR D 1 137 ? 98.553 -11.610 1.789 1.00 27.88 ? 461 THR D CB 1 ATOM 5955 O OG1 . THR D 1 137 ? 97.674 -10.977 2.723 1.00 27.12 ? 461 THR D OG1 1 ATOM 5956 C CG2 . THR D 1 137 ? 98.361 -13.108 1.862 1.00 26.55 ? 461 THR D CG2 1 ATOM 5957 N N . LEU D 1 138 ? 101.725 -12.868 1.602 1.00 26.30 ? 462 LEU D N 1 ATOM 5958 C CA . LEU D 1 138 ? 102.538 -13.665 0.714 1.00 25.13 ? 462 LEU D CA 1 ATOM 5959 C C . LEU D 1 138 ? 101.879 -15.023 0.530 1.00 25.65 ? 462 LEU D C 1 ATOM 5960 O O . LEU D 1 138 ? 101.227 -15.546 1.431 1.00 25.36 ? 462 LEU D O 1 ATOM 5961 C CB . LEU D 1 138 ? 103.938 -13.884 1.298 1.00 24.49 ? 462 LEU D CB 1 ATOM 5962 C CG . LEU D 1 138 ? 104.671 -12.617 1.729 1.00 24.18 ? 462 LEU D CG 1 ATOM 5963 C CD1 . LEU D 1 138 ? 106.080 -12.935 2.265 1.00 23.61 ? 462 LEU D CD1 1 ATOM 5964 C CD2 . LEU D 1 138 ? 104.682 -11.621 0.603 1.00 20.29 ? 462 LEU D CD2 1 ATOM 5965 N N . ALA D 1 139 ? 102.099 -15.598 -0.647 1.00 25.68 ? 463 ALA D N 1 ATOM 5966 C CA . ALA D 1 139 ? 101.490 -16.853 -1.026 1.00 24.07 ? 463 ALA D CA 1 ATOM 5967 C C . ALA D 1 139 ? 102.568 -17.711 -1.633 1.00 24.02 ? 463 ALA D C 1 ATOM 5968 O O . ALA D 1 139 ? 103.403 -17.242 -2.417 1.00 24.81 ? 463 ALA D O 1 ATOM 5969 C CB . ALA D 1 139 ? 100.400 -16.630 -2.034 1.00 22.36 ? 463 ALA D CB 1 ATOM 5970 N N . CYS D 1 140 ? 102.506 -18.982 -1.268 1.00 24.63 ? 464 CYS D N 1 ATOM 5971 C CA . CYS D 1 140 ? 103.431 -19.979 -1.747 1.00 26.31 ? 464 CYS D CA 1 ATOM 5972 C C . CYS D 1 140 ? 102.637 -21.132 -2.324 1.00 26.14 ? 464 CYS D C 1 ATOM 5973 O O . CYS D 1 140 ? 101.637 -21.562 -1.750 1.00 27.93 ? 464 CYS D O 1 ATOM 5974 C CB . CYS D 1 140 ? 104.289 -20.505 -0.593 1.00 27.69 ? 464 CYS D CB 1 ATOM 5975 S SG . CYS D 1 140 ? 105.722 -21.359 -1.221 1.00 29.83 ? 464 CYS D SG 1 ATOM 5976 N N . LEU D 1 141 ? 103.080 -21.633 -3.464 1.00 23.66 ? 465 LEU D N 1 ATOM 5977 C CA . LEU D 1 141 ? 102.405 -22.750 -4.100 1.00 21.52 ? 465 LEU D CA 1 ATOM 5978 C C . LEU D 1 141 ? 103.472 -23.762 -4.308 1.00 20.58 ? 465 LEU D C 1 ATOM 5979 O O . LEU D 1 141 ? 104.448 -23.453 -4.975 1.00 20.20 ? 465 LEU D O 1 ATOM 5980 C CB . LEU D 1 141 ? 101.849 -22.334 -5.460 1.00 21.35 ? 465 LEU D CB 1 ATOM 5981 C CG . LEU D 1 141 ? 101.402 -23.398 -6.465 1.00 22.43 ? 465 LEU D CG 1 ATOM 5982 C CD1 . LEU D 1 141 ? 100.407 -24.416 -5.882 1.00 24.21 ? 465 LEU D CD1 1 ATOM 5983 C CD2 . LEU D 1 141 ? 100.766 -22.675 -7.641 1.00 22.33 ? 465 LEU D CD2 1 ATOM 5984 N N . ILE D 1 142 ? 103.279 -24.946 -3.736 1.00 19.75 ? 466 ILE D N 1 ATOM 5985 C CA . ILE D 1 142 ? 104.220 -26.025 -3.848 1.00 21.20 ? 466 ILE D CA 1 ATOM 5986 C C . ILE D 1 142 ? 103.493 -27.197 -4.502 1.00 21.68 ? 466 ILE D C 1 ATOM 5987 O O . ILE D 1 142 ? 102.453 -27.635 -3.996 1.00 19.24 ? 466 ILE D O 1 ATOM 5988 C CB . ILE D 1 142 ? 104.685 -26.454 -2.456 1.00 23.40 ? 466 ILE D CB 1 ATOM 5989 C CG1 . ILE D 1 142 ? 105.035 -25.232 -1.611 1.00 24.28 ? 466 ILE D CG1 1 ATOM 5990 C CG2 . ILE D 1 142 ? 105.841 -27.440 -2.536 1.00 20.99 ? 466 ILE D CG2 1 ATOM 5991 C CD1 . ILE D 1 142 ? 105.371 -25.617 -0.201 1.00 26.11 ? 466 ILE D CD1 1 ATOM 5992 N N . GLN D 1 143 ? 104.025 -27.695 -5.621 1.00 21.32 ? 467 GLN D N 1 ATOM 5993 C CA . GLN D 1 143 ? 103.250 -28.629 -6.434 1.00 21.79 ? 467 GLN D CA 1 ATOM 5994 C C . GLN D 1 143 ? 104.121 -29.697 -7.089 1.00 23.25 ? 467 GLN D C 1 ATOM 5995 O O . GLN D 1 143 ? 105.343 -29.553 -7.137 1.00 22.89 ? 467 GLN D O 1 ATOM 5996 C CB . GLN D 1 143 ? 102.433 -27.894 -7.485 1.00 21.29 ? 467 GLN D CB 1 ATOM 5997 C CG . GLN D 1 143 ? 103.276 -27.047 -8.409 1.00 22.42 ? 467 GLN D CG 1 ATOM 5998 C CD . GLN D 1 143 ? 102.449 -26.466 -9.529 1.00 22.71 ? 467 GLN D CD 1 ATOM 5999 O OE1 . GLN D 1 143 ? 101.291 -26.157 -9.318 1.00 26.02 ? 467 GLN D OE1 1 ATOM 6000 N NE2 . GLN D 1 143 ? 103.020 -26.337 -10.724 1.00 21.98 ? 467 GLN D NE2 1 ATOM 6001 N N . ASN D 1 144 ? 103.468 -30.771 -7.534 1.00 24.65 ? 468 ASN D N 1 ATOM 6002 C CA . ASN D 1 144 ? 104.092 -31.811 -8.331 1.00 27.28 ? 468 ASN D CA 1 ATOM 6003 C C . ASN D 1 144 ? 105.130 -32.626 -7.556 1.00 27.07 ? 468 ASN D C 1 ATOM 6004 O O . ASN D 1 144 ? 106.064 -33.156 -8.154 1.00 26.20 ? 468 ASN D O 1 ATOM 6005 C CB . ASN D 1 144 ? 104.723 -31.198 -9.584 1.00 28.42 ? 468 ASN D CB 1 ATOM 6006 C CG . ASN D 1 144 ? 103.686 -30.609 -10.503 1.00 30.94 ? 468 ASN D CG 1 ATOM 6007 O OD1 . ASN D 1 144 ? 102.510 -30.968 -10.414 1.00 32.00 ? 468 ASN D OD1 1 ATOM 6008 N ND2 . ASN D 1 144 ? 104.104 -29.699 -11.387 1.00 31.20 ? 468 ASN D ND2 1 ATOM 6009 N N . PHE D 1 145 ? 104.962 -32.718 -6.233 1.00 26.99 ? 469 PHE D N 1 ATOM 6010 C CA . PHE D 1 145 ? 105.863 -33.511 -5.378 1.00 24.09 ? 469 PHE D CA 1 ATOM 6011 C C . PHE D 1 145 ? 105.180 -34.832 -5.132 1.00 23.00 ? 469 PHE D C 1 ATOM 6012 O O . PHE D 1 145 ? 103.972 -34.906 -5.222 1.00 20.16 ? 469 PHE D O 1 ATOM 6013 C CB . PHE D 1 145 ? 106.174 -32.815 -4.039 1.00 22.80 ? 469 PHE D CB 1 ATOM 6014 C CG . PHE D 1 145 ? 104.954 -32.337 -3.284 1.00 21.54 ? 469 PHE D CG 1 ATOM 6015 C CD1 . PHE D 1 145 ? 104.334 -33.132 -2.351 1.00 22.16 ? 469 PHE D CD1 1 ATOM 6016 C CD2 . PHE D 1 145 ? 104.427 -31.093 -3.501 1.00 22.88 ? 469 PHE D CD2 1 ATOM 6017 C CE1 . PHE D 1 145 ? 103.201 -32.713 -1.651 1.00 21.88 ? 469 PHE D CE1 1 ATOM 6018 C CE2 . PHE D 1 145 ? 103.289 -30.661 -2.795 1.00 23.32 ? 469 PHE D CE2 1 ATOM 6019 C CZ . PHE D 1 145 ? 102.682 -31.472 -1.872 1.00 21.23 ? 469 PHE D CZ 1 ATOM 6020 N N . MET D 1 146 ? 105.963 -35.872 -4.870 1.00 25.09 ? 470 MET D N 1 ATOM 6021 C CA . MET D 1 146 ? 105.424 -37.166 -4.458 1.00 28.11 ? 470 MET D CA 1 ATOM 6022 C C . MET D 1 146 ? 106.456 -37.925 -3.644 1.00 26.11 ? 470 MET D C 1 ATOM 6023 O O . MET D 1 146 ? 107.650 -37.824 -3.902 1.00 23.47 ? 470 MET D O 1 ATOM 6024 C CB . MET D 1 146 ? 104.877 -38.017 -5.617 1.00 31.43 ? 470 MET D CB 1 ATOM 6025 C CG . MET D 1 146 ? 105.696 -38.109 -6.884 1.00 34.44 ? 470 MET D CG 1 ATOM 6026 S SD . MET D 1 146 ? 104.794 -39.000 -8.224 1.00 38.57 ? 470 MET D SD 1 ATOM 6027 C CE . MET D 1 146 ? 103.518 -37.834 -8.598 1.00 38.56 ? 470 MET D CE 1 ATOM 6028 N N . PRO D 1 147 ? 106.000 -38.637 -2.612 1.00 25.82 ? 471 PRO D N 1 ATOM 6029 C CA . PRO D 1 147 ? 104.629 -38.739 -2.134 1.00 25.60 ? 471 PRO D CA 1 ATOM 6030 C C . PRO D 1 147 ? 104.167 -37.437 -1.490 1.00 24.82 ? 471 PRO D C 1 ATOM 6031 O O . PRO D 1 147 ? 104.846 -36.405 -1.615 1.00 22.87 ? 471 PRO D O 1 ATOM 6032 C CB . PRO D 1 147 ? 104.691 -39.862 -1.086 1.00 26.82 ? 471 PRO D CB 1 ATOM 6033 C CG . PRO D 1 147 ? 106.093 -40.360 -1.061 1.00 27.31 ? 471 PRO D CG 1 ATOM 6034 C CD . PRO D 1 147 ? 106.936 -39.288 -1.684 1.00 28.07 ? 471 PRO D CD 1 ATOM 6035 N N . GLU D 1 148 ? 103.029 -37.492 -0.808 1.00 24.99 ? 472 GLU D N 1 ATOM 6036 C CA . GLU D 1 148 ? 102.304 -36.278 -0.409 1.00 28.07 ? 472 GLU D CA 1 ATOM 6037 C C . GLU D 1 148 ? 102.844 -35.564 0.835 1.00 27.16 ? 472 GLU D C 1 ATOM 6038 O O . GLU D 1 148 ? 102.522 -34.403 1.089 1.00 27.95 ? 472 GLU D O 1 ATOM 6039 C CB . GLU D 1 148 ? 100.814 -36.592 -0.216 1.00 30.50 ? 472 GLU D CB 1 ATOM 6040 C CG . GLU D 1 148 ? 100.520 -37.536 0.917 1.00 33.49 ? 472 GLU D CG 1 ATOM 6041 C CD . GLU D 1 148 ? 99.124 -38.099 0.817 1.00 38.12 ? 472 GLU D CD 1 ATOM 6042 O OE1 . GLU D 1 148 ? 98.161 -37.294 0.724 1.00 41.77 ? 472 GLU D OE1 1 ATOM 6043 O OE2 . GLU D 1 148 ? 98.990 -39.349 0.833 1.00 40.99 ? 472 GLU D OE2 1 ATOM 6044 N N . ASP D 1 149 ? 103.663 -36.256 1.608 1.00 27.09 ? 473 ASP D N 1 ATOM 6045 C CA . ASP D 1 149 ? 104.101 -35.766 2.902 1.00 27.78 ? 473 ASP D CA 1 ATOM 6046 C C . ASP D 1 149 ? 105.082 -34.656 2.674 1.00 27.05 ? 473 ASP D C 1 ATOM 6047 O O . ASP D 1 149 ? 106.057 -34.839 1.945 1.00 26.50 ? 473 ASP D O 1 ATOM 6048 C CB . ASP D 1 149 ? 104.804 -36.861 3.700 1.00 30.51 ? 473 ASP D CB 1 ATOM 6049 C CG . ASP D 1 149 ? 103.830 -37.805 4.368 1.00 33.14 ? 473 ASP D CG 1 ATOM 6050 O OD1 . ASP D 1 149 ? 102.603 -37.576 4.247 1.00 35.47 ? 473 ASP D OD1 1 ATOM 6051 O OD2 . ASP D 1 149 ? 104.295 -38.769 5.016 1.00 35.60 ? 473 ASP D OD2 1 ATOM 6052 N N . ILE D 1 150 ? 104.811 -33.526 3.327 1.00 26.25 ? 474 ILE D N 1 ATOM 6053 C CA . ILE D 1 150 ? 105.536 -32.300 3.110 1.00 24.39 ? 474 ILE D CA 1 ATOM 6054 C C . ILE D 1 150 ? 105.338 -31.363 4.276 1.00 25.18 ? 474 ILE D C 1 ATOM 6055 O O . ILE D 1 150 ? 104.248 -31.264 4.824 1.00 25.74 ? 474 ILE D O 1 ATOM 6056 C CB . ILE D 1 150 ? 105.087 -31.604 1.838 1.00 24.11 ? 474 ILE D CB 1 ATOM 6057 C CG1 . ILE D 1 150 ? 106.123 -30.557 1.421 1.00 23.81 ? 474 ILE D CG1 1 ATOM 6058 C CG2 . ILE D 1 150 ? 103.710 -31.022 2.047 1.00 24.50 ? 474 ILE D CG2 1 ATOM 6059 C CD1 . ILE D 1 150 ? 106.218 -30.332 -0.060 1.00 22.21 ? 474 ILE D CD1 1 ATOM 6060 N N . SER D 1 151 ? 106.426 -30.704 4.657 1.00 24.24 ? 475 SER D N 1 ATOM 6061 C CA . SER D 1 151 ? 106.421 -29.700 5.671 1.00 24.58 ? 475 SER D CA 1 ATOM 6062 C C . SER D 1 151 ? 106.749 -28.367 5.012 1.00 26.65 ? 475 SER D C 1 ATOM 6063 O O . SER D 1 151 ? 107.708 -28.251 4.242 1.00 29.63 ? 475 SER D O 1 ATOM 6064 C CB . SER D 1 151 ? 107.482 -30.036 6.707 1.00 25.86 ? 475 SER D CB 1 ATOM 6065 O OG . SER D 1 151 ? 107.132 -31.167 7.478 1.00 26.79 ? 475 SER D OG 1 ATOM 6066 N N . VAL D 1 152 ? 105.950 -27.346 5.302 1.00 27.33 ? 476 VAL D N 1 ATOM 6067 C CA . VAL D 1 152 ? 106.180 -26.033 4.736 1.00 26.43 ? 476 VAL D CA 1 ATOM 6068 C C . VAL D 1 152 ? 106.548 -25.070 5.858 1.00 27.80 ? 476 VAL D C 1 ATOM 6069 O O . VAL D 1 152 ? 105.980 -25.119 6.938 1.00 26.07 ? 476 VAL D O 1 ATOM 6070 C CB . VAL D 1 152 ? 104.924 -25.531 4.043 1.00 26.36 ? 476 VAL D CB 1 ATOM 6071 C CG1 . VAL D 1 152 ? 105.090 -24.054 3.616 1.00 24.81 ? 476 VAL D CG1 1 ATOM 6072 C CG2 . VAL D 1 152 ? 104.604 -26.462 2.884 1.00 25.95 ? 476 VAL D CG2 1 ATOM 6073 N N . GLN D 1 153 ? 107.505 -24.189 5.615 1.00 28.96 ? 477 GLN D N 1 ATOM 6074 C CA . GLN D 1 153 ? 107.861 -23.240 6.640 1.00 29.66 ? 477 GLN D CA 1 ATOM 6075 C C . GLN D 1 153 ? 108.253 -21.929 5.998 1.00 29.86 ? 477 GLN D C 1 ATOM 6076 O O . GLN D 1 153 ? 108.665 -21.889 4.839 1.00 31.60 ? 477 GLN D O 1 ATOM 6077 C CB . GLN D 1 153 ? 108.945 -23.805 7.568 1.00 31.38 ? 477 GLN D CB 1 ATOM 6078 C CG . GLN D 1 153 ? 110.026 -24.554 6.862 1.00 34.33 ? 477 GLN D CG 1 ATOM 6079 C CD . GLN D 1 153 ? 110.963 -25.354 7.787 1.00 35.96 ? 477 GLN D CD 1 ATOM 6080 O OE1 . GLN D 1 153 ? 112.159 -25.486 7.504 1.00 36.47 ? 477 GLN D OE1 1 ATOM 6081 N NE2 . GLN D 1 153 ? 110.431 -25.891 8.874 1.00 37.13 ? 477 GLN D NE2 1 ATOM 6082 N N . TRP D 1 154 ? 108.083 -20.838 6.739 1.00 28.98 ? 478 TRP D N 1 ATOM 6083 C CA . TRP D 1 154 ? 108.490 -19.531 6.253 1.00 26.35 ? 478 TRP D CA 1 ATOM 6084 C C . TRP D 1 154 ? 109.650 -18.995 7.073 1.00 27.44 ? 478 TRP D C 1 ATOM 6085 O O . TRP D 1 154 ? 109.777 -19.282 8.273 1.00 26.88 ? 478 TRP D O 1 ATOM 6086 C CB . TRP D 1 154 ? 107.351 -18.541 6.334 1.00 25.63 ? 478 TRP D CB 1 ATOM 6087 C CG . TRP D 1 154 ? 106.264 -18.813 5.372 1.00 25.64 ? 478 TRP D CG 1 ATOM 6088 C CD1 . TRP D 1 154 ? 105.219 -19.678 5.536 1.00 25.92 ? 478 TRP D CD1 1 ATOM 6089 C CD2 . TRP D 1 154 ? 106.079 -18.201 4.095 1.00 25.66 ? 478 TRP D CD2 1 ATOM 6090 N NE1 . TRP D 1 154 ? 104.404 -19.655 4.424 1.00 25.91 ? 478 TRP D NE1 1 ATOM 6091 C CE2 . TRP D 1 154 ? 104.913 -18.744 3.535 1.00 26.08 ? 478 TRP D CE2 1 ATOM 6092 C CE3 . TRP D 1 154 ? 106.771 -17.227 3.383 1.00 27.13 ? 478 TRP D CE3 1 ATOM 6093 C CZ2 . TRP D 1 154 ? 104.448 -18.360 2.293 1.00 26.39 ? 478 TRP D CZ2 1 ATOM 6094 C CZ3 . TRP D 1 154 ? 106.314 -16.862 2.147 1.00 27.23 ? 478 TRP D CZ3 1 ATOM 6095 C CH2 . TRP D 1 154 ? 105.164 -17.419 1.613 1.00 26.69 ? 478 TRP D CH2 1 ATOM 6096 N N . LEU D 1 155 ? 110.503 -18.214 6.415 1.00 27.31 ? 479 LEU D N 1 ATOM 6097 C CA . LEU D 1 155 ? 111.657 -17.673 7.094 1.00 27.75 ? 479 LEU D CA 1 ATOM 6098 C C . LEU D 1 155 ? 111.764 -16.184 6.847 1.00 26.95 ? 479 LEU D C 1 ATOM 6099 O O . LEU D 1 155 ? 111.334 -15.665 5.815 1.00 26.80 ? 479 LEU D O 1 ATOM 6100 C CB . LEU D 1 155 ? 112.926 -18.361 6.623 1.00 29.07 ? 479 LEU D CB 1 ATOM 6101 C CG . LEU D 1 155 ? 112.829 -19.860 6.349 1.00 30.36 ? 479 LEU D CG 1 ATOM 6102 C CD1 . LEU D 1 155 ? 114.111 -20.304 5.680 1.00 30.61 ? 479 LEU D CD1 1 ATOM 6103 C CD2 . LEU D 1 155 ? 112.601 -20.602 7.632 1.00 31.27 ? 479 LEU D CD2 1 ATOM 6104 N N . HIS D 1 156 ? 112.374 -15.511 7.808 1.00 25.17 ? 480 HIS D N 1 ATOM 6105 C CA . HIS D 1 156 ? 112.689 -14.111 7.682 1.00 24.68 ? 480 HIS D CA 1 ATOM 6106 C C . HIS D 1 156 ? 113.964 -13.829 8.477 1.00 27.50 ? 480 HIS D C 1 ATOM 6107 O O . HIS D 1 156 ? 114.149 -14.319 9.610 1.00 24.60 ? 480 HIS D O 1 ATOM 6108 C CB . HIS D 1 156 ? 111.537 -13.291 8.201 1.00 23.09 ? 480 HIS D CB 1 ATOM 6109 C CG . HIS D 1 156 ? 111.652 -11.824 7.933 1.00 23.17 ? 480 HIS D CG 1 ATOM 6110 N ND1 . HIS D 1 156 ? 111.550 -10.882 8.933 1.00 21.60 ? 480 HIS D ND1 1 ATOM 6111 C CD2 . HIS D 1 156 ? 111.810 -11.132 6.780 1.00 24.16 ? 480 HIS D CD2 1 ATOM 6112 C CE1 . HIS D 1 156 ? 111.655 -9.673 8.412 1.00 21.84 ? 480 HIS D CE1 1 ATOM 6113 N NE2 . HIS D 1 156 ? 111.807 -9.793 7.107 1.00 23.05 ? 480 HIS D NE2 1 ATOM 6114 N N . ASN D 1 157 ? 114.825 -13.018 7.852 1.00 31.04 ? 481 ASN D N 1 ATOM 6115 C CA . ASN D 1 157 ? 116.219 -12.858 8.250 1.00 31.65 ? 481 ASN D CA 1 ATOM 6116 C C . ASN D 1 157 ? 116.798 -14.214 8.466 1.00 32.92 ? 481 ASN D C 1 ATOM 6117 O O . ASN D 1 157 ? 117.476 -14.419 9.456 1.00 35.48 ? 481 ASN D O 1 ATOM 6118 C CB . ASN D 1 157 ? 116.346 -12.108 9.558 1.00 31.61 ? 481 ASN D CB 1 ATOM 6119 C CG . ASN D 1 157 ? 115.475 -10.924 9.602 1.00 31.96 ? 481 ASN D CG 1 ATOM 6120 O OD1 . ASN D 1 157 ? 114.461 -10.913 10.306 1.00 32.23 ? 481 ASN D OD1 1 ATOM 6121 N ND2 . ASN D 1 157 ? 115.848 -9.900 8.843 1.00 34.09 ? 481 ASN D ND2 1 ATOM 6122 N N . GLU D 1 158 ? 116.500 -15.140 7.568 1.00 35.03 ? 482 GLU D N 1 ATOM 6123 C CA . GLU D 1 158 ? 117.088 -16.475 7.607 1.00 37.74 ? 482 GLU D CA 1 ATOM 6124 C C . GLU D 1 158 ? 116.712 -17.257 8.863 1.00 38.28 ? 482 GLU D C 1 ATOM 6125 O O . GLU D 1 158 ? 117.380 -18.237 9.211 1.00 38.91 ? 482 GLU D O 1 ATOM 6126 C CB . GLU D 1 158 ? 118.623 -16.403 7.471 1.00 40.15 ? 482 GLU D CB 1 ATOM 6127 C CG . GLU D 1 158 ? 119.144 -15.428 6.402 1.00 41.77 ? 482 GLU D CG 1 ATOM 6128 C CD . GLU D 1 158 ? 118.487 -15.648 5.042 1.00 44.23 ? 482 GLU D CD 1 ATOM 6129 O OE1 . GLU D 1 158 ? 118.248 -16.826 4.667 1.00 46.55 ? 482 GLU D OE1 1 ATOM 6130 O OE2 . GLU D 1 158 ? 118.193 -14.648 4.349 1.00 45.18 ? 482 GLU D OE2 1 ATOM 6131 N N . VAL D 1 159 ? 115.644 -16.842 9.543 1.00 39.19 ? 483 VAL D N 1 ATOM 6132 C CA . VAL D 1 159 ? 115.153 -17.602 10.696 1.00 38.74 ? 483 VAL D CA 1 ATOM 6133 C C . VAL D 1 159 ? 113.673 -17.870 10.597 1.00 37.30 ? 483 VAL D C 1 ATOM 6134 O O . VAL D 1 159 ? 112.900 -17.051 10.122 1.00 37.64 ? 483 VAL D O 1 ATOM 6135 C CB . VAL D 1 159 ? 115.402 -16.926 12.061 1.00 40.19 ? 483 VAL D CB 1 ATOM 6136 C CG1 . VAL D 1 159 ? 114.407 -15.806 12.306 1.00 41.34 ? 483 VAL D CG1 1 ATOM 6137 C CG2 . VAL D 1 159 ? 115.257 -17.953 13.161 1.00 39.34 ? 483 VAL D CG2 1 ATOM 6138 N N . GLN D 1 160 ? 113.299 -19.048 11.064 1.00 35.70 ? 484 GLN D N 1 ATOM 6139 C CA . GLN D 1 160 ? 111.960 -19.553 10.916 1.00 33.51 ? 484 GLN D CA 1 ATOM 6140 C C . GLN D 1 160 ? 111.014 -18.781 11.819 1.00 31.22 ? 484 GLN D C 1 ATOM 6141 O O . GLN D 1 160 ? 111.330 -18.498 12.975 1.00 28.16 ? 484 GLN D O 1 ATOM 6142 C CB . GLN D 1 160 ? 111.971 -21.030 11.297 1.00 34.40 ? 484 GLN D CB 1 ATOM 6143 C CG . GLN D 1 160 ? 110.775 -21.787 10.858 1.00 35.40 ? 484 GLN D CG 1 ATOM 6144 C CD . GLN D 1 160 ? 110.907 -23.272 11.152 1.00 38.72 ? 484 GLN D CD 1 ATOM 6145 O OE1 . GLN D 1 160 ? 109.912 -23.947 11.426 1.00 39.46 ? 484 GLN D OE1 1 ATOM 6146 N NE2 . GLN D 1 160 ? 112.137 -23.794 11.096 1.00 39.13 ? 484 GLN D NE2 1 ATOM 6147 N N . LEU D 1 161 ? 109.853 -18.439 11.271 1.00 30.47 ? 485 LEU D N 1 ATOM 6148 C CA . LEU D 1 161 ? 108.810 -17.754 12.017 1.00 30.46 ? 485 LEU D CA 1 ATOM 6149 C C . LEU D 1 161 ? 107.930 -18.780 12.718 1.00 31.64 ? 485 LEU D C 1 ATOM 6150 O O . LEU D 1 161 ? 107.922 -19.959 12.380 1.00 33.38 ? 485 LEU D O 1 ATOM 6151 C CB . LEU D 1 161 ? 107.963 -16.886 11.087 1.00 30.85 ? 485 LEU D CB 1 ATOM 6152 C CG . LEU D 1 161 ? 108.646 -15.804 10.247 1.00 30.76 ? 485 LEU D CG 1 ATOM 6153 C CD1 . LEU D 1 161 ? 107.616 -15.069 9.404 1.00 29.84 ? 485 LEU D CD1 1 ATOM 6154 C CD2 . LEU D 1 161 ? 109.393 -14.802 11.105 1.00 31.85 ? 485 LEU D CD2 1 ATOM 6155 N N . PRO D 1 162 ? 107.194 -18.346 13.738 1.00 33.19 ? 486 PRO D N 1 ATOM 6156 C CA . PRO D 1 162 ? 106.407 -19.356 14.457 1.00 32.86 ? 486 PRO D CA 1 ATOM 6157 C C . PRO D 1 162 ? 105.453 -20.045 13.503 1.00 33.46 ? 486 PRO D C 1 ATOM 6158 O O . PRO D 1 162 ? 105.093 -19.470 12.504 1.00 33.83 ? 486 PRO D O 1 ATOM 6159 C CB . PRO D 1 162 ? 105.652 -18.542 15.523 1.00 32.50 ? 486 PRO D CB 1 ATOM 6160 C CG . PRO D 1 162 ? 106.528 -17.292 15.734 1.00 32.54 ? 486 PRO D CG 1 ATOM 6161 C CD . PRO D 1 162 ? 107.196 -17.021 14.393 1.00 32.59 ? 486 PRO D CD 1 ATOM 6162 N N . ASP D 1 163 ? 105.051 -21.271 13.806 1.00 36.67 ? 487 ASP D N 1 ATOM 6163 C CA . ASP D 1 163 ? 104.107 -21.996 12.964 1.00 38.66 ? 487 ASP D CA 1 ATOM 6164 C C . ASP D 1 163 ? 102.773 -21.269 12.849 1.00 37.77 ? 487 ASP D C 1 ATOM 6165 O O . ASP D 1 163 ? 102.182 -21.256 11.776 1.00 37.98 ? 487 ASP D O 1 ATOM 6166 C CB . ASP D 1 163 ? 103.882 -23.427 13.479 1.00 40.54 ? 487 ASP D CB 1 ATOM 6167 C CG . ASP D 1 163 ? 105.164 -24.252 13.475 1.00 43.49 ? 487 ASP D CG 1 ATOM 6168 O OD1 . ASP D 1 163 ? 105.889 -24.227 12.447 1.00 44.65 ? 487 ASP D OD1 1 ATOM 6169 O OD2 . ASP D 1 163 ? 105.450 -24.917 14.501 1.00 45.49 ? 487 ASP D OD2 1 ATOM 6170 N N . ALA D 1 164 ? 102.298 -20.673 13.939 1.00 36.16 ? 488 ALA D N 1 ATOM 6171 C CA . ALA D 1 164 ? 100.947 -20.136 13.978 1.00 34.60 ? 488 ALA D CA 1 ATOM 6172 C C . ALA D 1 164 ? 100.757 -18.945 13.034 1.00 33.15 ? 488 ALA D C 1 ATOM 6173 O O . ALA D 1 164 ? 99.640 -18.528 12.767 1.00 32.54 ? 488 ALA D O 1 ATOM 6174 C CB . ALA D 1 164 ? 100.594 -19.740 15.419 1.00 34.56 ? 488 ALA D CB 1 ATOM 6175 N N . ARG D 1 165 ? 101.842 -18.366 12.539 1.00 33.20 ? 489 ARG D N 1 ATOM 6176 C CA . ARG D 1 165 ? 101.740 -17.202 11.647 1.00 34.17 ? 489 ARG D CA 1 ATOM 6177 C C . ARG D 1 165 ? 101.304 -17.528 10.217 1.00 33.92 ? 489 ARG D C 1 ATOM 6178 O O . ARG D 1 165 ? 100.826 -16.663 9.479 1.00 33.72 ? 489 ARG D O 1 ATOM 6179 C CB . ARG D 1 165 ? 103.097 -16.494 11.581 1.00 35.81 ? 489 ARG D CB 1 ATOM 6180 C CG . ARG D 1 165 ? 103.378 -15.730 12.853 1.00 36.94 ? 489 ARG D CG 1 ATOM 6181 C CD . ARG D 1 165 ? 102.991 -14.285 12.715 1.00 36.99 ? 489 ARG D CD 1 ATOM 6182 N NE . ARG D 1 165 ? 104.243 -13.580 12.532 1.00 38.29 ? 489 ARG D NE 1 ATOM 6183 C CZ . ARG D 1 165 ? 104.584 -12.886 11.464 1.00 37.19 ? 489 ARG D CZ 1 ATOM 6184 N NH1 . ARG D 1 165 ? 103.751 -12.744 10.456 1.00 36.52 ? 489 ARG D NH1 1 ATOM 6185 N NH2 . ARG D 1 165 ? 105.773 -12.310 11.441 1.00 38.02 ? 489 ARG D NH2 1 ATOM 6186 N N . HIS D 1 166 ? 101.496 -18.776 9.812 1.00 32.69 ? 490 HIS D N 1 ATOM 6187 C CA . HIS D 1 166 ? 101.189 -19.154 8.459 1.00 33.07 ? 490 HIS D CA 1 ATOM 6188 C C . HIS D 1 166 ? 100.114 -20.207 8.478 1.00 33.35 ? 490 HIS D C 1 ATOM 6189 O O . HIS D 1 166 ? 99.935 -20.925 9.445 1.00 34.24 ? 490 HIS D O 1 ATOM 6190 C CB . HIS D 1 166 ? 102.439 -19.618 7.709 1.00 33.47 ? 490 HIS D CB 1 ATOM 6191 C CG . HIS D 1 166 ? 102.951 -20.975 8.097 1.00 34.25 ? 490 HIS D CG 1 ATOM 6192 N ND1 . HIS D 1 166 ? 104.023 -21.155 8.948 1.00 34.88 ? 490 HIS D ND1 1 ATOM 6193 C CD2 . HIS D 1 166 ? 102.563 -22.217 7.720 1.00 34.60 ? 490 HIS D CD2 1 ATOM 6194 C CE1 . HIS D 1 166 ? 104.264 -22.449 9.084 1.00 34.69 ? 490 HIS D CE1 1 ATOM 6195 N NE2 . HIS D 1 166 ? 103.399 -23.115 8.340 1.00 34.06 ? 490 HIS D NE2 1 ATOM 6196 N N . SER D 1 167 ? 99.378 -20.274 7.387 1.00 34.41 ? 491 SER D N 1 ATOM 6197 C CA . SER D 1 167 ? 98.392 -21.325 7.183 1.00 32.97 ? 491 SER D CA 1 ATOM 6198 C C . SER D 1 167 ? 98.885 -22.195 6.030 1.00 32.21 ? 491 SER D C 1 ATOM 6199 O O . SER D 1 167 ? 99.510 -21.690 5.105 1.00 29.66 ? 491 SER D O 1 ATOM 6200 C CB . SER D 1 167 ? 97.092 -20.641 6.836 1.00 32.79 ? 491 SER D CB 1 ATOM 6201 O OG . SER D 1 167 ? 96.064 -21.551 7.047 1.00 36.50 ? 491 SER D OG 1 ATOM 6202 N N . THR D 1 168 ? 98.649 -23.501 6.077 1.00 32.91 ? 492 THR D N 1 ATOM 6203 C CA . THR D 1 168 ? 99.021 -24.352 4.940 1.00 31.78 ? 492 THR D CA 1 ATOM 6204 C C . THR D 1 168 ? 97.969 -25.410 4.664 1.00 30.24 ? 492 THR D C 1 ATOM 6205 O O . THR D 1 168 ? 97.567 -26.096 5.572 1.00 28.81 ? 492 THR D O 1 ATOM 6206 C CB . THR D 1 168 ? 100.375 -25.030 5.174 1.00 32.67 ? 492 THR D CB 1 ATOM 6207 O OG1 . THR D 1 168 ? 101.376 -24.014 5.245 1.00 33.70 ? 492 THR D OG1 1 ATOM 6208 C CG2 . THR D 1 168 ? 100.739 -25.966 4.024 1.00 32.13 ? 492 THR D CG2 1 ATOM 6209 N N . THR D 1 169 ? 97.530 -25.542 3.412 1.00 30.12 ? 493 THR D N 1 ATOM 6210 C CA . THR D 1 169 ? 96.408 -26.423 3.080 1.00 30.86 ? 493 THR D CA 1 ATOM 6211 C C . THR D 1 169 ? 96.843 -27.902 3.113 1.00 32.57 ? 493 THR D C 1 ATOM 6212 O O . THR D 1 169 ? 98.038 -28.199 3.160 1.00 31.36 ? 493 THR D O 1 ATOM 6213 C CB . THR D 1 169 ? 95.864 -26.121 1.677 1.00 29.46 ? 493 THR D CB 1 ATOM 6214 O OG1 . THR D 1 169 ? 96.920 -26.293 0.727 1.00 30.61 ? 493 THR D OG1 1 ATOM 6215 C CG2 . THR D 1 169 ? 95.358 -24.723 1.567 1.00 28.28 ? 493 THR D CG2 1 ATOM 6216 N N . GLN D 1 170 ? 95.881 -28.826 3.084 1.00 34.69 ? 494 GLN D N 1 ATOM 6217 C CA . GLN D 1 170 ? 96.213 -30.259 3.110 1.00 36.48 ? 494 GLN D CA 1 ATOM 6218 C C . GLN D 1 170 ? 96.528 -30.661 1.677 1.00 33.61 ? 494 GLN D C 1 ATOM 6219 O O . GLN D 1 170 ? 95.893 -30.175 0.737 1.00 32.22 ? 494 GLN D O 1 ATOM 6220 C CB . GLN D 1 170 ? 95.053 -31.149 3.614 1.00 40.42 ? 494 GLN D CB 1 ATOM 6221 C CG . GLN D 1 170 ? 94.499 -30.892 5.040 1.00 43.56 ? 494 GLN D CG 1 ATOM 6222 C CD . GLN D 1 170 ? 95.343 -31.489 6.158 1.00 45.56 ? 494 GLN D CD 1 ATOM 6223 O OE1 . GLN D 1 170 ? 95.335 -32.708 6.389 1.00 47.16 ? 494 GLN D OE1 1 ATOM 6224 N NE2 . GLN D 1 170 ? 96.057 -30.620 6.879 1.00 47.59 ? 494 GLN D NE2 1 ATOM 6225 N N . PRO D 1 171 ? 97.514 -31.547 1.507 1.00 31.52 ? 495 PRO D N 1 ATOM 6226 C CA . PRO D 1 171 ? 97.948 -31.967 0.186 1.00 32.88 ? 495 PRO D CA 1 ATOM 6227 C C . PRO D 1 171 ? 96.789 -32.543 -0.619 1.00 35.12 ? 495 PRO D C 1 ATOM 6228 O O . PRO D 1 171 ? 96.045 -33.355 -0.096 1.00 37.10 ? 495 PRO D O 1 ATOM 6229 C CB . PRO D 1 171 ? 98.994 -33.024 0.488 1.00 32.57 ? 495 PRO D CB 1 ATOM 6230 C CG . PRO D 1 171 ? 99.497 -32.722 1.867 1.00 31.56 ? 495 PRO D CG 1 ATOM 6231 C CD . PRO D 1 171 ? 98.420 -31.994 2.577 1.00 31.23 ? 495 PRO D CD 1 ATOM 6232 N N . ARG D 1 172 ? 96.617 -32.089 -1.854 1.00 36.80 ? 496 ARG D N 1 ATOM 6233 C CA . ARG D 1 172 ? 95.614 -32.617 -2.765 1.00 39.34 ? 496 ARG D CA 1 ATOM 6234 C C . ARG D 1 172 ? 96.300 -32.936 -4.082 1.00 38.78 ? 496 ARG D C 1 ATOM 6235 O O . ARG D 1 172 ? 97.327 -32.346 -4.415 1.00 35.00 ? 496 ARG D O 1 ATOM 6236 C CB . ARG D 1 172 ? 94.538 -31.585 -3.060 1.00 43.46 ? 496 ARG D CB 1 ATOM 6237 C CG . ARG D 1 172 ? 93.645 -31.157 -1.898 1.00 47.00 ? 496 ARG D CG 1 ATOM 6238 C CD . ARG D 1 172 ? 92.551 -30.225 -2.454 1.00 49.42 ? 496 ARG D CD 1 ATOM 6239 N NE . ARG D 1 172 ? 91.761 -29.548 -1.422 1.00 52.05 ? 496 ARG D NE 1 ATOM 6240 C CZ . ARG D 1 172 ? 90.542 -29.040 -1.615 1.00 53.09 ? 496 ARG D CZ 1 ATOM 6241 N NH1 . ARG D 1 172 ? 89.957 -29.127 -2.811 1.00 52.90 ? 496 ARG D NH1 1 ATOM 6242 N NH2 . ARG D 1 172 ? 89.907 -28.441 -0.605 1.00 53.40 ? 496 ARG D NH2 1 ATOM 6243 N N . LYS D 1 173 ? 95.731 -33.878 -4.825 1.00 40.46 ? 497 LYS D N 1 ATOM 6244 C CA . LYS D 1 173 ? 96.355 -34.348 -6.053 1.00 41.71 ? 497 LYS D CA 1 ATOM 6245 C C . LYS D 1 173 ? 96.230 -33.316 -7.151 1.00 42.33 ? 497 LYS D C 1 ATOM 6246 O O . LYS D 1 173 ? 95.226 -32.613 -7.241 1.00 41.33 ? 497 LYS D O 1 ATOM 6247 C CB . LYS D 1 173 ? 95.743 -35.663 -6.510 1.00 43.19 ? 497 LYS D CB 1 ATOM 6248 C CG . LYS D 1 173 ? 95.967 -36.782 -5.511 1.00 45.28 ? 497 LYS D CG 1 ATOM 6249 C CD . LYS D 1 173 ? 95.911 -38.161 -6.151 1.00 46.80 ? 497 LYS D CD 1 ATOM 6250 C CE . LYS D 1 173 ? 97.202 -38.514 -6.881 1.00 47.90 ? 497 LYS D CE 1 ATOM 6251 N NZ . LYS D 1 173 ? 97.254 -39.986 -7.216 1.00 48.63 ? 497 LYS D NZ 1 ATOM 6252 N N . THR D 1 174 ? 97.272 -33.235 -7.973 1.00 43.84 ? 498 THR D N 1 ATOM 6253 C CA . THR D 1 174 ? 97.275 -32.400 -9.164 1.00 44.66 ? 498 THR D CA 1 ATOM 6254 C C . THR D 1 174 ? 96.538 -33.161 -10.239 1.00 46.14 ? 498 THR D C 1 ATOM 6255 O O . THR D 1 174 ? 95.860 -34.149 -9.953 1.00 42.90 ? 498 THR D O 1 ATOM 6256 C CB . THR D 1 174 ? 98.698 -32.161 -9.681 1.00 44.96 ? 498 THR D CB 1 ATOM 6257 O OG1 . THR D 1 174 ? 99.250 -33.403 -10.131 1.00 43.84 ? 498 THR D OG1 1 ATOM 6258 C CG2 . THR D 1 174 ? 99.590 -31.557 -8.583 1.00 44.91 ? 498 THR D CG2 1 ATOM 6259 N N . LYS D 1 175 ? 96.671 -32.688 -11.474 1.00 49.71 ? 499 LYS D N 1 ATOM 6260 C CA . LYS D 1 175 ? 96.086 -33.379 -12.618 1.00 51.98 ? 499 LYS D CA 1 ATOM 6261 C C . LYS D 1 175 ? 96.999 -34.508 -13.033 1.00 51.60 ? 499 LYS D C 1 ATOM 6262 O O . LYS D 1 175 ? 96.513 -35.567 -13.397 1.00 50.48 ? 499 LYS D O 1 ATOM 6263 C CB . LYS D 1 175 ? 95.848 -32.428 -13.802 1.00 54.38 ? 499 LYS D CB 1 ATOM 6264 C CG . LYS D 1 175 ? 94.897 -31.259 -13.511 1.00 55.93 ? 499 LYS D CG 1 ATOM 6265 C CD . LYS D 1 175 ? 93.586 -31.709 -12.857 1.00 56.80 ? 499 LYS D CD 1 ATOM 6266 C CE . LYS D 1 175 ? 92.927 -30.549 -12.103 1.00 57.68 ? 499 LYS D CE 1 ATOM 6267 N NZ . LYS D 1 175 ? 91.959 -30.974 -11.039 1.00 57.47 ? 499 LYS D NZ 1 ATOM 6268 N N . GLY D 1 176 ? 98.310 -34.269 -12.967 1.00 53.19 ? 500 GLY D N 1 ATOM 6269 C CA . GLY D 1 176 ? 99.326 -35.288 -13.243 1.00 52.84 ? 500 GLY D CA 1 ATOM 6270 C C . GLY D 1 176 ? 99.256 -36.421 -12.239 1.00 52.63 ? 500 GLY D C 1 ATOM 6271 O O . GLY D 1 176 ? 98.176 -36.940 -11.958 1.00 52.85 ? 500 GLY D O 1 ATOM 6272 N N . SER D 1 177 ? 100.407 -36.812 -11.696 1.00 52.36 ? 501 SER D N 1 ATOM 6273 C CA . SER D 1 177 ? 100.458 -37.860 -10.674 1.00 51.09 ? 501 SER D CA 1 ATOM 6274 C C . SER D 1 177 ? 100.819 -37.279 -9.298 1.00 48.56 ? 501 SER D C 1 ATOM 6275 O O . SER D 1 177 ? 100.784 -37.999 -8.281 1.00 49.45 ? 501 SER D O 1 ATOM 6276 C CB . SER D 1 177 ? 101.456 -38.956 -11.083 1.00 52.04 ? 501 SER D CB 1 ATOM 6277 O OG . SER D 1 177 ? 101.331 -40.116 -10.269 1.00 52.65 ? 501 SER D OG 1 ATOM 6278 N N . GLY D 1 178 ? 101.152 -35.984 -9.277 1.00 43.49 ? 502 GLY D N 1 ATOM 6279 C CA . GLY D 1 178 ? 101.721 -35.353 -8.088 1.00 40.92 ? 502 GLY D CA 1 ATOM 6280 C C . GLY D 1 178 ? 100.713 -34.627 -7.226 1.00 37.34 ? 502 GLY D C 1 ATOM 6281 O O . GLY D 1 178 ? 99.511 -34.673 -7.505 1.00 37.65 ? 502 GLY D O 1 ATOM 6282 N N . PHE D 1 179 ? 101.198 -33.962 -6.176 1.00 32.81 ? 503 PHE D N 1 ATOM 6283 C CA . PHE D 1 179 ? 100.317 -33.246 -5.236 1.00 28.61 ? 503 PHE D CA 1 ATOM 6284 C C . PHE D 1 179 ? 100.662 -31.775 -5.167 1.00 25.39 ? 503 PHE D C 1 ATOM 6285 O O . PHE D 1 179 ? 101.739 -31.368 -5.597 1.00 25.15 ? 503 PHE D O 1 ATOM 6286 C CB . PHE D 1 179 ? 100.432 -33.817 -3.819 1.00 26.83 ? 503 PHE D CB 1 ATOM 6287 C CG . PHE D 1 179 ? 100.044 -35.257 -3.701 1.00 25.64 ? 503 PHE D CG 1 ATOM 6288 C CD1 . PHE D 1 179 ? 100.920 -36.252 -4.099 1.00 25.00 ? 503 PHE D CD1 1 ATOM 6289 C CD2 . PHE D 1 179 ? 98.821 -35.622 -3.169 1.00 24.95 ? 503 PHE D CD2 1 ATOM 6290 C CE1 . PHE D 1 179 ? 100.588 -37.585 -3.989 1.00 24.85 ? 503 PHE D CE1 1 ATOM 6291 C CE2 . PHE D 1 179 ? 98.486 -36.970 -3.052 1.00 25.85 ? 503 PHE D CE2 1 ATOM 6292 C CZ . PHE D 1 179 ? 99.372 -37.949 -3.469 1.00 24.99 ? 503 PHE D CZ 1 ATOM 6293 N N . PHE D 1 180 ? 99.754 -30.991 -4.598 1.00 23.13 ? 504 PHE D N 1 ATOM 6294 C CA . PHE D 1 180 ? 100.051 -29.615 -4.286 1.00 22.47 ? 504 PHE D CA 1 ATOM 6295 C C . PHE D 1 180 ? 99.524 -29.114 -2.951 1.00 24.59 ? 504 PHE D C 1 ATOM 6296 O O . PHE D 1 180 ? 98.563 -29.630 -2.373 1.00 21.80 ? 504 PHE D O 1 ATOM 6297 C CB . PHE D 1 180 ? 99.530 -28.692 -5.374 1.00 21.53 ? 504 PHE D CB 1 ATOM 6298 C CG . PHE D 1 180 ? 98.038 -28.487 -5.345 1.00 22.69 ? 504 PHE D CG 1 ATOM 6299 C CD1 . PHE D 1 180 ? 97.495 -27.347 -4.760 1.00 23.20 ? 504 PHE D CD1 1 ATOM 6300 C CD2 . PHE D 1 180 ? 97.171 -29.401 -5.929 1.00 23.12 ? 504 PHE D CD2 1 ATOM 6301 C CE1 . PHE D 1 180 ? 96.115 -27.122 -4.742 1.00 23.14 ? 504 PHE D CE1 1 ATOM 6302 C CE2 . PHE D 1 180 ? 95.787 -29.184 -5.916 1.00 23.92 ? 504 PHE D CE2 1 ATOM 6303 C CZ . PHE D 1 180 ? 95.262 -28.031 -5.319 1.00 23.60 ? 504 PHE D CZ 1 ATOM 6304 N N . VAL D 1 181 ? 100.169 -28.050 -2.472 1.00 27.37 ? 505 VAL D N 1 ATOM 6305 C CA . VAL D 1 181 ? 99.747 -27.393 -1.234 1.00 27.91 ? 505 VAL D CA 1 ATOM 6306 C C . VAL D 1 181 ? 99.887 -25.896 -1.414 1.00 24.59 ? 505 VAL D C 1 ATOM 6307 O O . VAL D 1 181 ? 100.723 -25.434 -2.159 1.00 24.70 ? 505 VAL D O 1 ATOM 6308 C CB . VAL D 1 181 ? 100.586 -27.895 -0.028 1.00 28.99 ? 505 VAL D CB 1 ATOM 6309 C CG1 . VAL D 1 181 ? 101.911 -27.173 0.046 1.00 27.82 ? 505 VAL D CG1 1 ATOM 6310 C CG2 . VAL D 1 181 ? 99.806 -27.706 1.267 1.00 33.12 ? 505 VAL D CG2 1 ATOM 6311 N N . PHE D 1 182 ? 99.031 -25.135 -0.768 1.00 26.20 ? 506 PHE D N 1 ATOM 6312 C CA . PHE D 1 182 ? 99.196 -23.684 -0.725 1.00 27.33 ? 506 PHE D CA 1 ATOM 6313 C C . PHE D 1 182 ? 99.576 -23.261 0.680 1.00 27.04 ? 506 PHE D C 1 ATOM 6314 O O . PHE D 1 182 ? 99.167 -23.865 1.674 1.00 32.39 ? 506 PHE D O 1 ATOM 6315 C CB . PHE D 1 182 ? 97.894 -22.962 -1.080 1.00 27.39 ? 506 PHE D CB 1 ATOM 6316 C CG . PHE D 1 182 ? 97.607 -22.861 -2.560 1.00 26.66 ? 506 PHE D CG 1 ATOM 6317 C CD1 . PHE D 1 182 ? 96.681 -23.692 -3.153 1.00 25.57 ? 506 PHE D CD1 1 ATOM 6318 C CD2 . PHE D 1 182 ? 98.247 -21.905 -3.349 1.00 26.77 ? 506 PHE D CD2 1 ATOM 6319 C CE1 . PHE D 1 182 ? 96.392 -23.580 -4.500 1.00 24.49 ? 506 PHE D CE1 1 ATOM 6320 C CE2 . PHE D 1 182 ? 97.973 -21.793 -4.697 1.00 24.63 ? 506 PHE D CE2 1 ATOM 6321 C CZ . PHE D 1 182 ? 97.039 -22.638 -5.268 1.00 25.34 ? 506 PHE D CZ 1 ATOM 6322 N N . SER D 1 183 ? 100.341 -22.193 0.778 1.00 26.62 ? 507 SER D N 1 ATOM 6323 C CA . SER D 1 183 ? 100.616 -21.623 2.069 1.00 25.77 ? 507 SER D CA 1 ATOM 6324 C C . SER D 1 183 ? 100.483 -20.114 2.071 1.00 25.44 ? 507 SER D C 1 ATOM 6325 O O . SER D 1 183 ? 100.873 -19.434 1.114 1.00 26.46 ? 507 SER D O 1 ATOM 6326 C CB . SER D 1 183 ? 102.010 -22.024 2.510 1.00 26.00 ? 507 SER D CB 1 ATOM 6327 O OG . SER D 1 183 ? 102.186 -21.634 3.860 1.00 27.70 ? 507 SER D OG 1 ATOM 6328 N N . ARG D 1 184 ? 99.945 -19.598 3.168 1.00 24.80 ? 508 ARG D N 1 ATOM 6329 C CA . ARG D 1 184 ? 99.633 -18.174 3.299 1.00 23.77 ? 508 ARG D CA 1 ATOM 6330 C C . ARG D 1 184 ? 100.275 -17.566 4.553 1.00 22.85 ? 508 ARG D C 1 ATOM 6331 O O . ARG D 1 184 ? 100.210 -18.156 5.629 1.00 22.77 ? 508 ARG D O 1 ATOM 6332 C CB . ARG D 1 184 ? 98.117 -17.990 3.353 1.00 23.18 ? 508 ARG D CB 1 ATOM 6333 C CG . ARG D 1 184 ? 97.646 -16.533 3.307 1.00 23.50 ? 508 ARG D CG 1 ATOM 6334 C CD . ARG D 1 184 ? 96.131 -16.442 3.424 1.00 24.66 ? 508 ARG D CD 1 ATOM 6335 N NE . ARG D 1 184 ? 95.680 -15.048 3.525 1.00 26.85 ? 508 ARG D NE 1 ATOM 6336 C CZ . ARG D 1 184 ? 95.518 -14.404 4.672 1.00 27.26 ? 508 ARG D CZ 1 ATOM 6337 N NH1 . ARG D 1 184 ? 95.782 -15.030 5.807 1.00 30.30 ? 508 ARG D NH1 1 ATOM 6338 N NH2 . ARG D 1 184 ? 95.102 -13.152 4.694 1.00 26.29 ? 508 ARG D NH2 1 ATOM 6339 N N . LEU D 1 185 ? 100.865 -16.384 4.388 1.00 22.11 ? 509 LEU D N 1 ATOM 6340 C CA . LEU D 1 185 ? 101.533 -15.632 5.448 1.00 21.66 ? 509 LEU D CA 1 ATOM 6341 C C . LEU D 1 185 ? 101.324 -14.141 5.291 1.00 22.26 ? 509 LEU D C 1 ATOM 6342 O O . LEU D 1 185 ? 101.851 -13.533 4.349 1.00 24.09 ? 509 LEU D O 1 ATOM 6343 C CB . LEU D 1 185 ? 103.046 -15.843 5.344 1.00 21.98 ? 509 LEU D CB 1 ATOM 6344 C CG . LEU D 1 185 ? 103.918 -15.310 6.489 1.00 21.12 ? 509 LEU D CG 1 ATOM 6345 C CD1 . LEU D 1 185 ? 103.580 -16.014 7.812 1.00 21.36 ? 509 LEU D CD1 1 ATOM 6346 C CD2 . LEU D 1 185 ? 105.352 -15.499 6.173 1.00 18.03 ? 509 LEU D CD2 1 ATOM 6347 N N . GLU D 1 186 ? 100.571 -13.557 6.214 1.00 23.41 ? 510 GLU D N 1 ATOM 6348 C CA . GLU D 1 186 ? 100.435 -12.111 6.356 1.00 22.83 ? 510 GLU D CA 1 ATOM 6349 C C . GLU D 1 186 ? 101.671 -11.522 6.995 1.00 23.37 ? 510 GLU D C 1 ATOM 6350 O O . GLU D 1 186 ? 102.026 -11.914 8.089 1.00 21.27 ? 510 GLU D O 1 ATOM 6351 C CB . GLU D 1 186 ? 99.277 -11.783 7.297 1.00 25.84 ? 510 GLU D CB 1 ATOM 6352 C CG . GLU D 1 186 ? 97.913 -12.276 6.797 1.00 31.64 ? 510 GLU D CG 1 ATOM 6353 C CD . GLU D 1 186 ? 96.717 -11.920 7.707 1.00 33.85 ? 510 GLU D CD 1 ATOM 6354 O OE1 . GLU D 1 186 ? 95.835 -12.805 7.799 1.00 35.20 ? 510 GLU D OE1 1 ATOM 6355 O OE2 . GLU D 1 186 ? 96.667 -10.804 8.301 1.00 33.77 ? 510 GLU D OE2 1 ATOM 6356 N N . VAL D 1 187 ? 102.293 -10.549 6.341 1.00 24.84 ? 511 VAL D N 1 ATOM 6357 C CA . VAL D 1 187 ? 103.469 -9.906 6.872 1.00 26.97 ? 511 VAL D CA 1 ATOM 6358 C C . VAL D 1 187 ? 103.182 -8.435 7.131 1.00 29.74 ? 511 VAL D C 1 ATOM 6359 O O . VAL D 1 187 ? 102.265 -7.872 6.519 1.00 31.19 ? 511 VAL D O 1 ATOM 6360 C CB . VAL D 1 187 ? 104.655 -10.026 5.888 1.00 27.63 ? 511 VAL D CB 1 ATOM 6361 C CG1 . VAL D 1 187 ? 105.156 -11.469 5.843 1.00 26.14 ? 511 VAL D CG1 1 ATOM 6362 C CG2 . VAL D 1 187 ? 104.278 -9.501 4.495 1.00 24.69 ? 511 VAL D CG2 1 ATOM 6363 N N . THR D 1 188 ? 103.955 -7.817 8.030 1.00 30.50 ? 512 THR D N 1 ATOM 6364 C CA . THR D 1 188 ? 103.768 -6.401 8.347 1.00 30.15 ? 512 THR D CA 1 ATOM 6365 C C . THR D 1 188 ? 104.831 -5.526 7.675 1.00 30.31 ? 512 THR D C 1 ATOM 6366 O O . THR D 1 188 ? 105.904 -6.003 7.286 1.00 30.01 ? 512 THR D O 1 ATOM 6367 C CB . THR D 1 188 ? 103.865 -6.139 9.851 1.00 29.88 ? 512 THR D CB 1 ATOM 6368 O OG1 . THR D 1 188 ? 105.239 -6.236 10.234 1.00 31.52 ? 512 THR D OG1 1 ATOM 6369 C CG2 . THR D 1 188 ? 103.035 -7.125 10.652 1.00 29.84 ? 512 THR D CG2 1 ATOM 6370 N N . ARG D 1 189 ? 104.526 -4.234 7.554 1.00 30.66 ? 513 ARG D N 1 ATOM 6371 C CA . ARG D 1 189 ? 105.457 -3.244 7.004 1.00 30.00 ? 513 ARG D CA 1 ATOM 6372 C C . ARG D 1 189 ? 106.758 -3.250 7.796 1.00 30.71 ? 513 ARG D C 1 ATOM 6373 O O . ARG D 1 189 ? 107.838 -3.150 7.211 1.00 32.23 ? 513 ARG D O 1 ATOM 6374 C CB . ARG D 1 189 ? 104.850 -1.835 7.044 1.00 30.56 ? 513 ARG D CB 1 ATOM 6375 C CG . ARG D 1 189 ? 105.838 -0.690 6.702 1.00 31.11 ? 513 ARG D CG 1 ATOM 6376 C CD . ARG D 1 189 ? 105.123 0.656 6.442 1.00 31.79 ? 513 ARG D CD 1 ATOM 6377 N NE . ARG D 1 189 ? 104.358 0.705 5.187 1.00 31.27 ? 513 ARG D NE 1 ATOM 6378 C CZ . ARG D 1 189 ? 104.920 0.816 3.986 1.00 31.51 ? 513 ARG D CZ 1 ATOM 6379 N NH1 . ARG D 1 189 ? 106.239 0.887 3.874 1.00 32.72 ? 513 ARG D NH1 1 ATOM 6380 N NH2 . ARG D 1 189 ? 104.181 0.849 2.892 1.00 30.51 ? 513 ARG D NH2 1 ATOM 6381 N N . ALA D 1 190 ? 106.669 -3.378 9.120 1.00 29.43 ? 514 ALA D N 1 ATOM 6382 C CA . ALA D 1 190 ? 107.872 -3.372 9.957 1.00 29.17 ? 514 ALA D CA 1 ATOM 6383 C C . ALA D 1 190 ? 108.828 -4.490 9.541 1.00 28.19 ? 514 ALA D C 1 ATOM 6384 O O . ALA D 1 190 ? 110.036 -4.312 9.546 1.00 31.11 ? 514 ALA D O 1 ATOM 6385 C CB . ALA D 1 190 ? 107.508 -3.481 11.454 1.00 27.23 ? 514 ALA D CB 1 ATOM 6386 N N . GLU D 1 191 ? 108.297 -5.647 9.168 1.00 27.56 ? 515 GLU D N 1 ATOM 6387 C CA . GLU D 1 191 ? 109.147 -6.789 8.847 1.00 26.00 ? 515 GLU D CA 1 ATOM 6388 C C . GLU D 1 191 ? 109.837 -6.657 7.509 1.00 26.03 ? 515 GLU D C 1 ATOM 6389 O O . GLU D 1 191 ? 111.035 -6.893 7.393 1.00 24.65 ? 515 GLU D O 1 ATOM 6390 C CB . GLU D 1 191 ? 108.345 -8.082 8.861 1.00 25.57 ? 515 GLU D CB 1 ATOM 6391 C CG . GLU D 1 191 ? 107.862 -8.435 10.242 1.00 25.68 ? 515 GLU D CG 1 ATOM 6392 C CD . GLU D 1 191 ? 106.863 -9.572 10.250 1.00 26.91 ? 515 GLU D CD 1 ATOM 6393 O OE1 . GLU D 1 191 ? 106.901 -10.376 11.186 1.00 29.01 ? 515 GLU D OE1 1 ATOM 6394 O OE2 . GLU D 1 191 ? 106.031 -9.688 9.333 1.00 28.85 ? 515 GLU D OE2 1 ATOM 6395 N N . TRP D 1 192 ? 109.091 -6.277 6.482 1.00 27.93 ? 516 TRP D N 1 ATOM 6396 C CA . TRP D 1 192 ? 109.713 -6.187 5.176 1.00 29.42 ? 516 TRP D CA 1 ATOM 6397 C C . TRP D 1 192 ? 110.583 -4.960 5.097 1.00 31.69 ? 516 TRP D C 1 ATOM 6398 O O . TRP D 1 192 ? 111.496 -4.890 4.280 1.00 34.91 ? 516 TRP D O 1 ATOM 6399 C CB . TRP D 1 192 ? 108.678 -6.246 4.043 1.00 29.41 ? 516 TRP D CB 1 ATOM 6400 C CG . TRP D 1 192 ? 107.911 -4.992 3.697 1.00 27.75 ? 516 TRP D CG 1 ATOM 6401 C CD1 . TRP D 1 192 ? 108.411 -3.855 3.135 1.00 28.10 ? 516 TRP D CD1 1 ATOM 6402 C CD2 . TRP D 1 192 ? 106.498 -4.773 3.848 1.00 25.82 ? 516 TRP D CD2 1 ATOM 6403 N NE1 . TRP D 1 192 ? 107.403 -2.934 2.942 1.00 27.30 ? 516 TRP D NE1 1 ATOM 6404 C CE2 . TRP D 1 192 ? 106.219 -3.472 3.367 1.00 26.20 ? 516 TRP D CE2 1 ATOM 6405 C CE3 . TRP D 1 192 ? 105.452 -5.540 4.342 1.00 24.14 ? 516 TRP D CE3 1 ATOM 6406 C CZ2 . TRP D 1 192 ? 104.931 -2.925 3.361 1.00 25.48 ? 516 TRP D CZ2 1 ATOM 6407 C CZ3 . TRP D 1 192 ? 104.165 -4.990 4.349 1.00 26.22 ? 516 TRP D CZ3 1 ATOM 6408 C CH2 . TRP D 1 192 ? 103.919 -3.692 3.858 1.00 25.34 ? 516 TRP D CH2 1 ATOM 6409 N N . GLU D 1 193 ? 110.307 -3.991 5.957 1.00 33.90 ? 517 GLU D N 1 ATOM 6410 C CA . GLU D 1 193 ? 111.054 -2.742 5.940 1.00 35.96 ? 517 GLU D CA 1 ATOM 6411 C C . GLU D 1 193 ? 112.386 -2.962 6.618 1.00 36.77 ? 517 GLU D C 1 ATOM 6412 O O . GLU D 1 193 ? 113.381 -2.340 6.270 1.00 37.29 ? 517 GLU D O 1 ATOM 6413 C CB . GLU D 1 193 ? 110.281 -1.670 6.692 1.00 37.41 ? 517 GLU D CB 1 ATOM 6414 C CG . GLU D 1 193 ? 110.330 -0.309 6.059 1.00 38.37 ? 517 GLU D CG 1 ATOM 6415 C CD . GLU D 1 193 ? 109.141 0.530 6.447 1.00 39.12 ? 517 GLU D CD 1 ATOM 6416 O OE1 . GLU D 1 193 ? 109.005 0.843 7.660 1.00 39.96 ? 517 GLU D OE1 1 ATOM 6417 O OE2 . GLU D 1 193 ? 108.361 0.876 5.529 1.00 39.34 ? 517 GLU D OE2 1 ATOM 6418 N N . GLN D 1 194 ? 112.388 -3.856 7.599 1.00 37.18 ? 518 GLN D N 1 ATOM 6419 C CA . GLN D 1 194 ? 113.620 -4.375 8.166 1.00 37.46 ? 518 GLN D CA 1 ATOM 6420 C C . GLN D 1 194 ? 114.406 -5.242 7.178 1.00 36.72 ? 518 GLN D C 1 ATOM 6421 O O . GLN D 1 194 ? 115.612 -5.086 7.029 1.00 37.67 ? 518 GLN D O 1 ATOM 6422 C CB . GLN D 1 194 ? 113.282 -5.192 9.406 1.00 38.40 ? 518 GLN D CB 1 ATOM 6423 C CG . GLN D 1 194 ? 114.463 -5.927 9.991 1.00 38.87 ? 518 GLN D CG 1 ATOM 6424 C CD . GLN D 1 194 ? 114.019 -6.906 11.041 1.00 40.09 ? 518 GLN D CD 1 ATOM 6425 O OE1 . GLN D 1 194 ? 113.202 -7.806 10.774 1.00 38.92 ? 518 GLN D OE1 1 ATOM 6426 N NE2 . GLN D 1 194 ? 114.537 -6.726 12.261 1.00 39.90 ? 518 GLN D NE2 1 ATOM 6427 N N . LYS D 1 195 ? 113.739 -6.164 6.504 1.00 36.43 ? 519 LYS D N 1 ATOM 6428 C CA . LYS D 1 195 ? 114.416 -6.964 5.478 1.00 37.38 ? 519 LYS D CA 1 ATOM 6429 C C . LYS D 1 195 ? 113.384 -7.531 4.499 1.00 36.75 ? 519 LYS D C 1 ATOM 6430 O O . LYS D 1 195 ? 112.644 -8.463 4.826 1.00 35.19 ? 519 LYS D O 1 ATOM 6431 C CB . LYS D 1 195 ? 115.239 -8.068 6.149 1.00 37.47 ? 519 LYS D CB 1 ATOM 6432 C CG . LYS D 1 195 ? 115.889 -9.059 5.231 1.00 37.92 ? 519 LYS D CG 1 ATOM 6433 C CD . LYS D 1 195 ? 117.079 -8.489 4.522 1.00 38.16 ? 519 LYS D CD 1 ATOM 6434 C CE . LYS D 1 195 ? 117.752 -9.565 3.680 1.00 37.56 ? 519 LYS D CE 1 ATOM 6435 N NZ . LYS D 1 195 ? 118.812 -8.938 2.876 1.00 38.27 ? 519 LYS D NZ 1 ATOM 6436 N N . ASP D 1 196 ? 113.339 -6.945 3.303 1.00 37.73 ? 520 ASP D N 1 ATOM 6437 C CA . ASP D 1 196 ? 112.331 -7.285 2.304 1.00 37.44 ? 520 ASP D CA 1 ATOM 6438 C C . ASP D 1 196 ? 112.672 -8.557 1.520 1.00 37.11 ? 520 ASP D C 1 ATOM 6439 O O . ASP D 1 196 ? 112.843 -8.517 0.300 1.00 36.72 ? 520 ASP D O 1 ATOM 6440 C CB . ASP D 1 196 ? 112.121 -6.136 1.322 1.00 37.46 ? 520 ASP D CB 1 ATOM 6441 C CG . ASP D 1 196 ? 110.990 -6.425 0.353 1.00 37.98 ? 520 ASP D CG 1 ATOM 6442 O OD1 . ASP D 1 196 ? 110.221 -7.364 0.646 1.00 38.55 ? 520 ASP D OD1 1 ATOM 6443 O OD2 . ASP D 1 196 ? 110.864 -5.748 -0.685 1.00 37.74 ? 520 ASP D OD2 1 ATOM 6444 N N . GLU D 1 197 ? 112.760 -9.684 2.223 1.00 35.62 ? 521 GLU D N 1 ATOM 6445 C CA . GLU D 1 197 ? 112.977 -10.973 1.582 1.00 35.82 ? 521 GLU D CA 1 ATOM 6446 C C . GLU D 1 197 ? 112.467 -12.055 2.516 1.00 34.43 ? 521 GLU D C 1 ATOM 6447 O O . GLU D 1 197 ? 113.013 -12.264 3.596 1.00 35.77 ? 521 GLU D O 1 ATOM 6448 C CB . GLU D 1 197 ? 114.452 -11.227 1.244 1.00 36.32 ? 521 GLU D CB 1 ATOM 6449 C CG . GLU D 1 197 ? 114.672 -12.594 0.610 1.00 37.69 ? 521 GLU D CG 1 ATOM 6450 C CD . GLU D 1 197 ? 115.935 -12.733 -0.256 1.00 39.49 ? 521 GLU D CD 1 ATOM 6451 O OE1 . GLU D 1 197 ? 116.156 -11.948 -1.211 1.00 40.69 ? 521 GLU D OE1 1 ATOM 6452 O OE2 . GLU D 1 197 ? 116.715 -13.671 0.006 1.00 40.29 ? 521 GLU D OE2 1 ATOM 6453 N N . PHE D 1 198 ? 111.410 -12.729 2.078 1.00 32.68 ? 522 PHE D N 1 ATOM 6454 C CA . PHE D 1 198 ? 110.803 -13.817 2.820 1.00 30.05 ? 522 PHE D CA 1 ATOM 6455 C C . PHE D 1 198 ? 110.962 -15.135 2.075 1.00 28.72 ? 522 PHE D C 1 ATOM 6456 O O . PHE D 1 198 ? 110.895 -15.197 0.850 1.00 30.75 ? 522 PHE D O 1 ATOM 6457 C CB . PHE D 1 198 ? 109.345 -13.473 3.061 1.00 29.52 ? 522 PHE D CB 1 ATOM 6458 C CG . PHE D 1 198 ? 109.158 -12.168 3.755 1.00 27.82 ? 522 PHE D CG 1 ATOM 6459 C CD1 . PHE D 1 198 ? 109.328 -10.970 3.072 1.00 28.18 ? 522 PHE D CD1 1 ATOM 6460 C CD2 . PHE D 1 198 ? 108.820 -12.141 5.094 1.00 28.06 ? 522 PHE D CD2 1 ATOM 6461 C CE1 . PHE D 1 198 ? 109.141 -9.751 3.710 1.00 28.47 ? 522 PHE D CE1 1 ATOM 6462 C CE2 . PHE D 1 198 ? 108.635 -10.938 5.751 1.00 27.70 ? 522 PHE D CE2 1 ATOM 6463 C CZ . PHE D 1 198 ? 108.800 -9.736 5.062 1.00 28.27 ? 522 PHE D CZ 1 ATOM 6464 N N . ILE D 1 199 ? 111.230 -16.196 2.815 1.00 28.64 ? 523 ILE D N 1 ATOM 6465 C CA . ILE D 1 199 ? 111.518 -17.481 2.195 1.00 25.59 ? 523 ILE D CA 1 ATOM 6466 C C . ILE D 1 199 ? 110.437 -18.507 2.513 1.00 25.69 ? 523 ILE D C 1 ATOM 6467 O O . ILE D 1 199 ? 110.055 -18.731 3.655 1.00 23.32 ? 523 ILE D O 1 ATOM 6468 C CB . ILE D 1 199 ? 112.910 -17.950 2.567 1.00 25.05 ? 523 ILE D CB 1 ATOM 6469 C CG1 . ILE D 1 199 ? 113.918 -16.879 2.116 1.00 25.08 ? 523 ILE D CG1 1 ATOM 6470 C CG2 . ILE D 1 199 ? 113.223 -19.275 1.883 1.00 25.52 ? 523 ILE D CG2 1 ATOM 6471 C CD1 . ILE D 1 199 ? 115.229 -17.410 1.562 1.00 25.33 ? 523 ILE D CD1 1 ATOM 6472 N N . CYS D 1 200 ? 109.899 -19.090 1.454 1.00 27.31 ? 524 CYS D N 1 ATOM 6473 C CA . CYS D 1 200 ? 108.996 -20.218 1.570 1.00 27.56 ? 524 CYS D CA 1 ATOM 6474 C C . CYS D 1 200 ? 109.850 -21.448 1.413 1.00 26.53 ? 524 CYS D C 1 ATOM 6475 O O . CYS D 1 200 ? 110.473 -21.631 0.383 1.00 25.09 ? 524 CYS D O 1 ATOM 6476 C CB . CYS D 1 200 ? 107.975 -20.198 0.439 1.00 28.32 ? 524 CYS D CB 1 ATOM 6477 S SG . CYS D 1 200 ? 106.935 -21.660 0.425 1.00 29.10 ? 524 CYS D SG 1 ATOM 6478 N N . ARG D 1 201 ? 109.901 -22.285 2.437 1.00 28.89 ? 525 ARG D N 1 ATOM 6479 C CA . ARG D 1 201 ? 110.722 -23.493 2.372 1.00 29.82 ? 525 ARG D CA 1 ATOM 6480 C C . ARG D 1 201 ? 109.945 -24.781 2.642 1.00 29.03 ? 525 ARG D C 1 ATOM 6481 O O . ARG D 1 201 ? 109.129 -24.873 3.572 1.00 27.18 ? 525 ARG D O 1 ATOM 6482 C CB . ARG D 1 201 ? 111.868 -23.392 3.354 1.00 31.12 ? 525 ARG D CB 1 ATOM 6483 C CG . ARG D 1 201 ? 112.671 -24.655 3.438 1.00 33.04 ? 525 ARG D CG 1 ATOM 6484 C CD . ARG D 1 201 ? 114.053 -24.308 3.863 1.00 33.98 ? 525 ARG D CD 1 ATOM 6485 N NE . ARG D 1 201 ? 114.142 -24.400 5.300 1.00 35.97 ? 525 ARG D NE 1 ATOM 6486 C CZ . ARG D 1 201 ? 115.083 -23.820 6.044 1.00 37.02 ? 525 ARG D CZ 1 ATOM 6487 N NH1 . ARG D 1 201 ? 116.023 -23.053 5.484 1.00 36.34 ? 525 ARG D NH1 1 ATOM 6488 N NH2 . ARG D 1 201 ? 115.051 -24.009 7.363 1.00 35.94 ? 525 ARG D NH2 1 ATOM 6489 N N . ALA D 1 202 ? 110.224 -25.776 1.809 1.00 29.78 ? 526 ALA D N 1 ATOM 6490 C CA . ALA D 1 202 ? 109.532 -27.058 1.870 1.00 30.19 ? 526 ALA D CA 1 ATOM 6491 C C . ALA D 1 202 ? 110.542 -28.136 2.185 1.00 29.23 ? 526 ALA D C 1 ATOM 6492 O O . ALA D 1 202 ? 111.544 -28.262 1.479 1.00 30.00 ? 526 ALA D O 1 ATOM 6493 C CB . ALA D 1 202 ? 108.881 -27.368 0.540 1.00 29.21 ? 526 ALA D CB 1 ATOM 6494 N N . VAL D 1 203 ? 110.264 -28.911 3.225 1.00 26.00 ? 527 VAL D N 1 ATOM 6495 C CA . VAL D 1 203 ? 111.027 -30.107 3.502 1.00 23.06 ? 527 VAL D CA 1 ATOM 6496 C C . VAL D 1 203 ? 110.311 -31.293 2.865 1.00 24.26 ? 527 VAL D C 1 ATOM 6497 O O . VAL D 1 203 ? 109.116 -31.508 3.099 1.00 22.26 ? 527 VAL D O 1 ATOM 6498 C CB . VAL D 1 203 ? 111.220 -30.326 5.022 1.00 21.70 ? 527 VAL D CB 1 ATOM 6499 C CG1 . VAL D 1 203 ? 112.150 -31.496 5.285 1.00 18.34 ? 527 VAL D CG1 1 ATOM 6500 C CG2 . VAL D 1 203 ? 111.811 -29.087 5.686 1.00 19.01 ? 527 VAL D CG2 1 ATOM 6501 N N . HIS D 1 204 ? 111.040 -32.049 2.035 1.00 25.37 ? 528 HIS D N 1 ATOM 6502 C CA . HIS D 1 204 ? 110.462 -33.174 1.309 1.00 25.13 ? 528 HIS D CA 1 ATOM 6503 C C . HIS D 1 204 ? 111.540 -34.155 0.946 1.00 27.15 ? 528 HIS D C 1 ATOM 6504 O O . HIS D 1 204 ? 112.612 -33.761 0.482 1.00 27.78 ? 528 HIS D O 1 ATOM 6505 C CB . HIS D 1 204 ? 109.794 -32.736 0.007 1.00 24.63 ? 528 HIS D CB 1 ATOM 6506 C CG . HIS D 1 204 ? 108.935 -33.789 -0.628 1.00 23.57 ? 528 HIS D CG 1 ATOM 6507 N ND1 . HIS D 1 204 ? 109.442 -34.754 -1.470 1.00 24.68 ? 528 HIS D ND1 1 ATOM 6508 C CD2 . HIS D 1 204 ? 107.600 -34.008 -0.570 1.00 23.77 ? 528 HIS D CD2 1 ATOM 6509 C CE1 . HIS D 1 204 ? 108.455 -35.521 -1.902 1.00 24.47 ? 528 HIS D CE1 1 ATOM 6510 N NE2 . HIS D 1 204 ? 107.325 -35.096 -1.365 1.00 23.32 ? 528 HIS D NE2 1 ATOM 6511 N N . GLU D 1 205 ? 111.203 -35.426 1.136 1.00 27.77 ? 529 GLU D N 1 ATOM 6512 C CA . GLU D 1 205 ? 112.066 -36.565 0.852 1.00 29.81 ? 529 GLU D CA 1 ATOM 6513 C C . GLU D 1 205 ? 112.777 -36.552 -0.512 1.00 28.68 ? 529 GLU D C 1 ATOM 6514 O O . GLU D 1 205 ? 113.929 -36.929 -0.614 1.00 27.19 ? 529 GLU D O 1 ATOM 6515 C CB . GLU D 1 205 ? 111.229 -37.832 0.969 1.00 31.18 ? 529 GLU D CB 1 ATOM 6516 C CG . GLU D 1 205 ? 112.015 -39.099 0.709 1.00 35.20 ? 529 GLU D CG 1 ATOM 6517 C CD . GLU D 1 205 ? 111.120 -40.342 0.615 1.00 37.06 ? 529 GLU D CD 1 ATOM 6518 O OE1 . GLU D 1 205 ? 111.663 -41.424 0.296 1.00 37.25 ? 529 GLU D OE1 1 ATOM 6519 O OE2 . GLU D 1 205 ? 109.888 -40.217 0.855 1.00 38.50 ? 529 GLU D OE2 1 ATOM 6520 N N . ALA D 1 206 ? 112.102 -36.129 -1.566 1.00 28.25 ? 530 ALA D N 1 ATOM 6521 C CA . ALA D 1 206 ? 112.714 -36.188 -2.875 1.00 27.86 ? 530 ALA D CA 1 ATOM 6522 C C . ALA D 1 206 ? 113.554 -34.944 -3.143 1.00 28.23 ? 530 ALA D C 1 ATOM 6523 O O . ALA D 1 206 ? 114.346 -34.928 -4.068 1.00 26.65 ? 530 ALA D O 1 ATOM 6524 C CB . ALA D 1 206 ? 111.658 -36.356 -3.951 1.00 26.69 ? 530 ALA D CB 1 ATOM 6525 N N . ALA D 1 207 ? 113.404 -33.892 -2.349 1.00 29.66 ? 531 ALA D N 1 ATOM 6526 C CA . ALA D 1 207 ? 114.138 -32.669 -2.670 1.00 31.40 ? 531 ALA D CA 1 ATOM 6527 C C . ALA D 1 207 ? 115.617 -32.850 -2.409 1.00 33.05 ? 531 ALA D C 1 ATOM 6528 O O . ALA D 1 207 ? 116.021 -33.509 -1.454 1.00 36.27 ? 531 ALA D O 1 ATOM 6529 C CB . ALA D 1 207 ? 113.607 -31.447 -1.922 1.00 29.90 ? 531 ALA D CB 1 ATOM 6530 N N . SER D 1 208 ? 116.425 -32.260 -3.277 1.00 33.82 ? 532 SER D N 1 ATOM 6531 C CA . SER D 1 208 ? 117.850 -32.513 -3.259 1.00 33.34 ? 532 SER D CA 1 ATOM 6532 C C . SER D 1 208 ? 118.616 -31.227 -3.542 1.00 32.72 ? 532 SER D C 1 ATOM 6533 O O . SER D 1 208 ? 118.200 -30.401 -4.365 1.00 31.67 ? 532 SER D O 1 ATOM 6534 C CB . SER D 1 208 ? 118.194 -33.566 -4.296 1.00 33.95 ? 532 SER D CB 1 ATOM 6535 O OG . SER D 1 208 ? 119.588 -33.638 -4.453 1.00 35.31 ? 532 SER D OG 1 ATOM 6536 N N . PRO D 1 209 ? 119.730 -31.033 -2.823 1.00 31.92 ? 533 PRO D N 1 ATOM 6537 C CA . PRO D 1 209 ? 120.170 -31.874 -1.724 1.00 31.59 ? 533 PRO D CA 1 ATOM 6538 C C . PRO D 1 209 ? 119.489 -31.467 -0.417 1.00 31.28 ? 533 PRO D C 1 ATOM 6539 O O . PRO D 1 209 ? 118.696 -30.518 -0.381 1.00 30.21 ? 533 PRO D O 1 ATOM 6540 C CB . PRO D 1 209 ? 121.666 -31.569 -1.660 1.00 32.05 ? 533 PRO D CB 1 ATOM 6541 C CG . PRO D 1 209 ? 121.753 -30.135 -2.063 1.00 31.65 ? 533 PRO D CG 1 ATOM 6542 C CD . PRO D 1 209 ? 120.622 -29.876 -3.014 1.00 32.04 ? 533 PRO D CD 1 ATOM 6543 N N . SER D 1 210 ? 119.784 -32.185 0.657 1.00 31.73 ? 534 SER D N 1 ATOM 6544 C CA . SER D 1 210 ? 119.373 -31.729 1.982 1.00 32.56 ? 534 SER D CA 1 ATOM 6545 C C . SER D 1 210 ? 117.848 -31.818 2.180 1.00 31.72 ? 534 SER D C 1 ATOM 6546 O O . SER D 1 210 ? 117.304 -31.229 3.108 1.00 31.84 ? 534 SER D O 1 ATOM 6547 C CB . SER D 1 210 ? 119.830 -30.273 2.191 1.00 32.60 ? 534 SER D CB 1 ATOM 6548 O OG . SER D 1 210 ? 121.136 -30.021 1.696 1.00 32.21 ? 534 SER D OG 1 ATOM 6549 N N . GLN D 1 211 ? 117.177 -32.555 1.302 1.00 31.90 ? 535 GLN D N 1 ATOM 6550 C CA . GLN D 1 211 ? 115.713 -32.641 1.246 1.00 31.78 ? 535 GLN D CA 1 ATOM 6551 C C . GLN D 1 211 ? 114.969 -31.347 1.594 1.00 33.06 ? 535 GLN D C 1 ATOM 6552 O O . GLN D 1 211 ? 114.004 -31.321 2.373 1.00 31.02 ? 535 GLN D O 1 ATOM 6553 C CB . GLN D 1 211 ? 115.193 -33.844 2.043 1.00 31.15 ? 535 GLN D CB 1 ATOM 6554 C CG . GLN D 1 211 ? 115.999 -34.240 3.224 1.00 31.01 ? 535 GLN D CG 1 ATOM 6555 C CD . GLN D 1 211 ? 117.202 -35.101 2.913 1.00 30.22 ? 535 GLN D CD 1 ATOM 6556 O OE1 . GLN D 1 211 ? 118.025 -35.334 3.795 1.00 29.95 ? 535 GLN D OE1 1 ATOM 6557 N NE2 . GLN D 1 211 ? 117.319 -35.570 1.681 1.00 29.68 ? 535 GLN D NE2 1 ATOM 6558 N N . THR D 1 212 ? 115.426 -30.280 0.947 1.00 33.68 ? 536 THR D N 1 ATOM 6559 C CA . THR D 1 212 ? 114.896 -28.951 1.149 1.00 33.64 ? 536 THR D CA 1 ATOM 6560 C C . THR D 1 212 ? 114.823 -28.188 -0.163 1.00 32.87 ? 536 THR D C 1 ATOM 6561 O O . THR D 1 212 ? 115.769 -28.209 -0.950 1.00 31.87 ? 536 THR D O 1 ATOM 6562 C CB . THR D 1 212 ? 115.817 -28.192 2.077 1.00 35.46 ? 536 THR D CB 1 ATOM 6563 O OG1 . THR D 1 212 ? 115.360 -28.392 3.418 1.00 36.34 ? 536 THR D OG1 1 ATOM 6564 C CG2 . THR D 1 212 ? 115.830 -26.718 1.717 1.00 36.78 ? 536 THR D CG2 1 ATOM 6565 N N . VAL D 1 213 ? 113.692 -27.537 -0.412 1.00 31.28 ? 537 VAL D N 1 ATOM 6566 C CA . VAL D 1 213 ? 113.600 -26.615 -1.525 1.00 30.54 ? 537 VAL D CA 1 ATOM 6567 C C . VAL D 1 213 ? 112.922 -25.329 -1.051 1.00 30.12 ? 537 VAL D C 1 ATOM 6568 O O . VAL D 1 213 ? 111.998 -25.333 -0.233 1.00 30.96 ? 537 VAL D O 1 ATOM 6569 C CB . VAL D 1 213 ? 112.880 -27.221 -2.763 1.00 30.64 ? 537 VAL D CB 1 ATOM 6570 C CG1 . VAL D 1 213 ? 112.870 -26.216 -3.951 1.00 29.94 ? 537 VAL D CG1 1 ATOM 6571 C CG2 . VAL D 1 213 ? 113.608 -28.433 -3.237 1.00 32.01 ? 537 VAL D CG2 1 ATOM 6572 N N . GLN D 1 214 ? 113.392 -24.212 -1.581 1.00 29.67 ? 538 GLN D N 1 ATOM 6573 C CA . GLN D 1 214 ? 112.929 -22.931 -1.112 1.00 29.52 ? 538 GLN D CA 1 ATOM 6574 C C . GLN D 1 214 ? 112.882 -21.894 -2.226 1.00 30.97 ? 538 GLN D C 1 ATOM 6575 O O . GLN D 1 214 ? 113.548 -22.023 -3.250 1.00 29.17 ? 538 GLN D O 1 ATOM 6576 C CB . GLN D 1 214 ? 113.798 -22.456 0.037 1.00 28.37 ? 538 GLN D CB 1 ATOM 6577 C CG . GLN D 1 214 ? 115.166 -21.914 -0.328 1.00 28.60 ? 538 GLN D CG 1 ATOM 6578 C CD . GLN D 1 214 ? 115.927 -21.459 0.924 1.00 29.32 ? 538 GLN D CD 1 ATOM 6579 O OE1 . GLN D 1 214 ? 115.928 -22.159 1.940 1.00 31.31 ? 538 GLN D OE1 1 ATOM 6580 N NE2 . GLN D 1 214 ? 116.537 -20.273 0.871 1.00 28.40 ? 538 GLN D NE2 1 ATOM 6581 N N . ARG D 1 215 ? 112.075 -20.863 -2.013 1.00 31.69 ? 539 ARG D N 1 ATOM 6582 C CA . ARG D 1 215 ? 112.002 -19.784 -2.951 1.00 33.52 ? 539 ARG D CA 1 ATOM 6583 C C . ARG D 1 215 ? 111.849 -18.509 -2.150 1.00 33.27 ? 539 ARG D C 1 ATOM 6584 O O . ARG D 1 215 ? 111.089 -18.460 -1.183 1.00 34.79 ? 539 ARG D O 1 ATOM 6585 C CB . ARG D 1 215 ? 110.828 -20.004 -3.895 1.00 37.10 ? 539 ARG D CB 1 ATOM 6586 C CG . ARG D 1 215 ? 110.690 -18.955 -4.974 1.00 41.23 ? 539 ARG D CG 1 ATOM 6587 C CD . ARG D 1 215 ? 111.684 -19.166 -6.089 1.00 44.92 ? 539 ARG D CD 1 ATOM 6588 N NE . ARG D 1 215 ? 111.573 -18.128 -7.119 1.00 48.39 ? 539 ARG D NE 1 ATOM 6589 C CZ . ARG D 1 215 ? 112.320 -18.071 -8.225 1.00 51.54 ? 539 ARG D CZ 1 ATOM 6590 N NH1 . ARG D 1 215 ? 113.252 -18.993 -8.476 1.00 52.17 ? 539 ARG D NH1 1 ATOM 6591 N NH2 . ARG D 1 215 ? 112.134 -17.084 -9.098 1.00 52.86 ? 539 ARG D NH2 1 ATOM 6592 N N . ALA D 1 216 ? 112.601 -17.491 -2.554 1.00 31.36 ? 540 ALA D N 1 ATOM 6593 C CA . ALA D 1 216 ? 112.543 -16.171 -1.948 1.00 30.78 ? 540 ALA D CA 1 ATOM 6594 C C . ALA D 1 216 ? 111.476 -15.326 -2.632 1.00 30.04 ? 540 ALA D C 1 ATOM 6595 O O . ALA D 1 216 ? 111.183 -15.505 -3.811 1.00 29.97 ? 540 ALA D O 1 ATOM 6596 C CB . ALA D 1 216 ? 113.900 -15.485 -2.077 1.00 28.18 ? 540 ALA D CB 1 ATOM 6597 N N . VAL D 1 217 ? 110.904 -14.386 -1.890 1.00 29.15 ? 541 VAL D N 1 ATOM 6598 C CA . VAL D 1 217 ? 110.009 -13.403 -2.492 1.00 27.81 ? 541 VAL D CA 1 ATOM 6599 C C . VAL D 1 217 ? 110.131 -12.082 -1.738 1.00 28.30 ? 541 VAL D C 1 ATOM 6600 O O . VAL D 1 217 ? 110.286 -12.090 -0.516 1.00 26.92 ? 541 VAL D O 1 ATOM 6601 C CB . VAL D 1 217 ? 108.551 -13.887 -2.468 1.00 27.22 ? 541 VAL D CB 1 ATOM 6602 C CG1 . VAL D 1 217 ? 108.088 -14.115 -1.019 1.00 26.41 ? 541 VAL D CG1 1 ATOM 6603 C CG2 . VAL D 1 217 ? 107.664 -12.911 -3.205 1.00 26.61 ? 541 VAL D CG2 1 ATOM 6604 N N . SER D 1 218 ? 110.092 -10.967 -2.472 1.00 29.43 ? 542 SER D N 1 ATOM 6605 C CA . SER D 1 218 ? 110.152 -9.629 -1.889 1.00 30.07 ? 542 SER D CA 1 ATOM 6606 C C . SER D 1 218 ? 108.851 -8.886 -2.139 1.00 32.48 ? 542 SER D C 1 ATOM 6607 O O . SER D 1 218 ? 108.247 -8.990 -3.209 1.00 34.00 ? 542 SER D O 1 ATOM 6608 C CB . SER D 1 218 ? 111.306 -8.814 -2.488 1.00 29.75 ? 542 SER D CB 1 ATOM 6609 O OG . SER D 1 218 ? 112.581 -9.387 -2.231 1.00 29.21 ? 542 SER D OG 1 ATOM 6610 N N . VAL D 1 219 ? 108.418 -8.126 -1.145 1.00 34.74 ? 543 VAL D N 1 ATOM 6611 C CA . VAL D 1 219 ? 107.200 -7.362 -1.278 1.00 38.17 ? 543 VAL D CA 1 ATOM 6612 C C . VAL D 1 219 ? 107.291 -6.298 -2.369 1.00 41.03 ? 543 VAL D C 1 ATOM 6613 O O . VAL D 1 219 ? 106.277 -5.985 -3.006 1.00 42.01 ? 543 VAL D O 1 ATOM 6614 C CB . VAL D 1 219 ? 106.812 -6.706 0.052 1.00 38.92 ? 543 VAL D CB 1 ATOM 6615 C CG1 . VAL D 1 219 ? 105.767 -5.599 -0.197 1.00 37.79 ? 543 VAL D CG1 1 ATOM 6616 C CG2 . VAL D 1 219 ? 106.323 -7.779 1.044 1.00 36.06 ? 543 VAL D CG2 1 ATOM 6617 N N . ASN D 1 220 ? 108.490 -5.758 -2.594 1.00 43.07 ? 544 ASN D N 1 ATOM 6618 C CA . ASN D 1 220 ? 108.701 -4.806 -3.677 1.00 44.94 ? 544 ASN D CA 1 ATOM 6619 C C . ASN D 1 220 ? 109.924 -5.176 -4.504 1.00 45.91 ? 544 ASN D C 1 ATOM 6620 O O . ASN D 1 220 ? 109.940 -6.216 -5.158 1.00 46.74 ? 544 ASN D O 1 ATOM 6621 C CB . ASN D 1 220 ? 108.848 -3.396 -3.102 1.00 46.91 ? 544 ASN D CB 1 ATOM 6622 C CG . ASN D 1 220 ? 107.546 -2.861 -2.512 1.00 48.04 ? 544 ASN D CG 1 ATOM 6623 O OD1 . ASN D 1 220 ? 106.503 -2.845 -3.178 1.00 48.65 ? 544 ASN D OD1 1 ATOM 6624 N ND2 . ASN D 1 220 ? 107.608 -2.416 -1.256 1.00 47.10 ? 544 ASN D ND2 1 HETATM 6625 C C1 . NAG E 2 . ? 108.861 -29.162 56.597 1.00 63.57 ? 1 NAG B C1 1 HETATM 6626 C C2 . NAG E 2 . ? 108.881 -29.482 55.109 1.00 64.11 ? 1 NAG B C2 1 HETATM 6627 C C3 . NAG E 2 . ? 110.244 -30.013 54.711 1.00 64.43 ? 1 NAG B C3 1 HETATM 6628 C C4 . NAG E 2 . ? 111.319 -28.986 55.068 1.00 64.42 ? 1 NAG B C4 1 HETATM 6629 C C5 . NAG E 2 . ? 111.141 -28.605 56.532 1.00 64.12 ? 1 NAG B C5 1 HETATM 6630 C C6 . NAG E 2 . ? 112.218 -27.631 56.983 1.00 63.74 ? 1 NAG B C6 1 HETATM 6631 C C7 . NAG E 2 . ? 106.820 -30.189 54.040 1.00 64.04 ? 1 NAG B C7 1 HETATM 6632 C C8 . NAG E 2 . ? 105.880 -31.328 53.786 1.00 64.06 ? 1 NAG B C8 1 HETATM 6633 N N2 . NAG E 2 . ? 107.888 -30.484 54.781 1.00 64.08 ? 1 NAG B N2 1 HETATM 6634 O O3 . NAG E 2 . ? 110.171 -30.267 53.325 1.00 64.84 ? 1 NAG B O3 1 HETATM 6635 O O4 . NAG E 2 . ? 112.614 -29.544 54.986 1.00 64.17 ? 1 NAG B O4 1 HETATM 6636 O O5 . NAG E 2 . ? 109.833 -28.164 56.832 1.00 63.54 ? 1 NAG B O5 1 HETATM 6637 O O6 . NAG E 2 . ? 111.731 -26.993 58.142 1.00 63.56 ? 1 NAG B O6 1 HETATM 6638 O O7 . NAG E 2 . ? 106.579 -29.070 53.581 1.00 63.60 ? 1 NAG B O7 1 HETATM 6639 C C1 . NAG F 2 . ? 113.281 -29.207 53.763 1.00 64.51 ? 2 NAG B C1 1 HETATM 6640 C C2 . NAG F 2 . ? 114.786 -29.215 54.038 1.00 65.20 ? 2 NAG B C2 1 HETATM 6641 C C3 . NAG F 2 . ? 115.574 -29.133 52.733 1.00 65.26 ? 2 NAG B C3 1 HETATM 6642 C C4 . NAG F 2 . ? 115.097 -30.182 51.724 1.00 65.16 ? 2 NAG B C4 1 HETATM 6643 C C5 . NAG F 2 . ? 113.584 -30.054 51.545 1.00 64.14 ? 2 NAG B C5 1 HETATM 6644 C C6 . NAG F 2 . ? 112.992 -31.032 50.538 1.00 63.39 ? 2 NAG B C6 1 HETATM 6645 C C7 . NAG F 2 . ? 116.008 -27.981 55.821 1.00 66.82 ? 2 NAG B C7 1 HETATM 6646 C C8 . NAG F 2 . ? 116.151 -26.667 56.534 1.00 66.55 ? 2 NAG B C8 1 HETATM 6647 N N2 . NAG F 2 . ? 115.088 -28.040 54.849 1.00 66.16 ? 2 NAG B N2 1 HETATM 6648 O O3 . NAG F 2 . ? 116.935 -29.383 53.009 1.00 64.67 ? 2 NAG B O3 1 HETATM 6649 O O4 . NAG F 2 . ? 115.695 -29.917 50.471 1.00 66.08 ? 2 NAG B O4 1 HETATM 6650 O O5 . NAG F 2 . ? 112.880 -30.121 52.767 1.00 64.09 ? 2 NAG B O5 1 HETATM 6651 O O6 . NAG F 2 . ? 112.818 -32.273 51.176 1.00 62.85 ? 2 NAG B O6 1 HETATM 6652 O O7 . NAG F 2 . ? 116.730 -28.915 56.166 1.00 67.76 ? 2 NAG B O7 1 HETATM 6653 C C1 . BMA G 3 . ? 116.731 -30.822 50.052 1.00 66.58 ? 3 BMA B C1 1 HETATM 6654 C C2 . BMA G 3 . ? 116.504 -31.026 48.565 1.00 66.68 ? 3 BMA B C2 1 HETATM 6655 C C3 . BMA G 3 . ? 117.560 -31.955 48.002 1.00 67.55 ? 3 BMA B C3 1 HETATM 6656 C C4 . BMA G 3 . ? 118.938 -31.430 48.352 1.00 67.55 ? 3 BMA B C4 1 HETATM 6657 C C5 . BMA G 3 . ? 119.086 -31.124 49.828 1.00 67.74 ? 3 BMA B C5 1 HETATM 6658 C C6 . BMA G 3 . ? 120.512 -30.596 50.009 1.00 68.26 ? 3 BMA B C6 1 HETATM 6659 O O2 . BMA G 3 . ? 116.619 -29.785 47.918 1.00 66.41 ? 3 BMA B O2 1 HETATM 6660 O O3 . BMA G 3 . ? 117.523 -31.851 46.605 1.00 68.46 ? 3 BMA B O3 1 HETATM 6661 O O4 . BMA G 3 . ? 119.893 -32.407 48.018 1.00 67.07 ? 3 BMA B O4 1 HETATM 6662 O O5 . BMA G 3 . ? 118.026 -30.294 50.266 1.00 67.39 ? 3 BMA B O5 1 HETATM 6663 O O6 . BMA G 3 . ? 120.652 -29.606 51.009 1.00 69.75 ? 3 BMA B O6 1 HETATM 6664 C C1 . MAN H 4 . ? 120.337 -28.250 50.607 1.00 69.87 ? 4 MAN B C1 1 HETATM 6665 C C2 . MAN H 4 . ? 120.889 -27.836 49.247 1.00 69.82 ? 4 MAN B C2 1 HETATM 6666 C C3 . MAN H 4 . ? 122.401 -28.006 49.202 1.00 69.80 ? 4 MAN B C3 1 HETATM 6667 C C4 . MAN H 4 . ? 123.035 -27.306 50.399 1.00 70.01 ? 4 MAN B C4 1 HETATM 6668 C C5 . MAN H 4 . ? 122.270 -27.433 51.725 1.00 69.94 ? 4 MAN B C5 1 HETATM 6669 C C6 . MAN H 4 . ? 122.686 -26.320 52.694 1.00 69.82 ? 4 MAN B C6 1 HETATM 6670 O O2 . MAN H 4 . ? 120.639 -26.458 49.082 1.00 69.15 ? 4 MAN B O2 1 HETATM 6671 O O3 . MAN H 4 . ? 122.936 -27.505 47.989 1.00 68.71 ? 4 MAN B O3 1 HETATM 6672 O O4 . MAN H 4 . ? 124.292 -27.924 50.544 1.00 70.18 ? 4 MAN B O4 1 HETATM 6673 O O5 . MAN H 4 . ? 120.871 -27.329 51.533 1.00 70.32 ? 4 MAN B O5 1 HETATM 6674 O O6 . MAN H 4 . ? 123.330 -26.819 53.844 1.00 68.38 ? 4 MAN B O6 1 HETATM 6675 C C1 . MAN I 4 . ? 117.257 -33.102 45.950 1.00 69.59 ? 5 MAN B C1 1 HETATM 6676 C C2 . MAN I 4 . ? 117.949 -33.046 44.600 1.00 69.84 ? 5 MAN B C2 1 HETATM 6677 C C3 . MAN I 4 . ? 117.431 -31.811 43.882 1.00 69.89 ? 5 MAN B C3 1 HETATM 6678 C C4 . MAN I 4 . ? 115.945 -32.032 43.641 1.00 70.00 ? 5 MAN B C4 1 HETATM 6679 C C5 . MAN I 4 . ? 115.329 -32.183 45.030 1.00 69.98 ? 5 MAN B C5 1 HETATM 6680 C C6 . MAN I 4 . ? 113.816 -32.340 45.031 1.00 70.06 ? 5 MAN B C6 1 HETATM 6681 O O2 . MAN I 4 . ? 117.545 -34.191 43.877 1.00 69.75 ? 5 MAN B O2 1 HETATM 6682 O O3 . MAN I 4 . ? 118.174 -31.570 42.713 1.00 70.18 ? 5 MAN B O3 1 HETATM 6683 O O4 . MAN I 4 . ? 115.384 -30.949 42.934 1.00 70.26 ? 5 MAN B O4 1 HETATM 6684 O O5 . MAN I 4 . ? 115.889 -33.313 45.670 1.00 69.84 ? 5 MAN B O5 1 HETATM 6685 O O6 . MAN I 4 . ? 113.382 -31.901 46.298 1.00 69.60 ? 5 MAN B O6 1 HETATM 6686 C C1 . NAG J 2 . ? 82.574 -43.989 0.983 1.00 59.85 ? 1 NAG C C1 1 HETATM 6687 C C2 . NAG J 2 . ? 82.799 -43.266 2.312 1.00 60.66 ? 1 NAG C C2 1 HETATM 6688 C C3 . NAG J 2 . ? 81.823 -42.096 2.432 1.00 60.96 ? 1 NAG C C3 1 HETATM 6689 C C4 . NAG J 2 . ? 81.981 -41.136 1.255 1.00 60.57 ? 1 NAG C C4 1 HETATM 6690 C C5 . NAG J 2 . ? 81.809 -41.960 -0.022 1.00 59.64 ? 1 NAG C C5 1 HETATM 6691 C C6 . NAG J 2 . ? 81.880 -41.150 -1.314 1.00 58.73 ? 1 NAG C C6 1 HETATM 6692 C C7 . NAG J 2 . ? 83.588 -44.521 4.274 1.00 61.44 ? 1 NAG C C7 1 HETATM 6693 C C8 . NAG J 2 . ? 83.274 -45.540 5.331 1.00 61.43 ? 1 NAG C C8 1 HETATM 6694 N N2 . NAG J 2 . ? 82.631 -44.229 3.391 1.00 61.45 ? 1 NAG C N2 1 HETATM 6695 O O3 . NAG J 2 . ? 82.011 -41.387 3.635 1.00 61.48 ? 1 NAG C O3 1 HETATM 6696 O O4 . NAG J 2 . ? 80.993 -40.125 1.331 1.00 61.14 ? 1 NAG C O4 1 HETATM 6697 O O5 . NAG J 2 . ? 82.715 -43.049 -0.063 1.00 59.73 ? 1 NAG C O5 1 HETATM 6698 O O6 . NAG J 2 . ? 83.083 -40.428 -1.405 1.00 57.42 ? 1 NAG C O6 1 HETATM 6699 O O7 . NAG J 2 . ? 84.692 -43.989 4.258 1.00 61.68 ? 1 NAG C O7 1 HETATM 6700 C C1 . NAG K 2 . ? 81.552 -38.847 1.698 1.00 61.89 ? 2 NAG C C1 1 HETATM 6701 C C2 . NAG K 2 . ? 80.840 -37.731 0.936 1.00 61.79 ? 2 NAG C C2 1 HETATM 6702 C C3 . NAG K 2 . ? 81.312 -36.359 1.427 1.00 62.52 ? 2 NAG C C3 1 HETATM 6703 C C4 . NAG K 2 . ? 81.220 -36.216 2.944 1.00 62.84 ? 2 NAG C C4 1 HETATM 6704 C C5 . NAG K 2 . ? 81.896 -37.409 3.610 1.00 62.75 ? 2 NAG C C5 1 HETATM 6705 C C6 . NAG K 2 . ? 81.718 -37.368 5.125 1.00 62.33 ? 2 NAG C C6 1 HETATM 6706 C C7 . NAG K 2 . ? 80.173 -37.833 -1.432 1.00 59.88 ? 2 NAG C C7 1 HETATM 6707 C C8 . NAG K 2 . ? 80.638 -37.903 -2.852 1.00 59.18 ? 2 NAG C C8 1 HETATM 6708 N N2 . NAG K 2 . ? 81.124 -37.815 -0.493 1.00 60.82 ? 2 NAG C N2 1 HETATM 6709 O O3 . NAG K 2 . ? 80.520 -35.332 0.859 1.00 62.14 ? 2 NAG C O3 1 HETATM 6710 O O4 . NAG K 2 . ? 81.897 -35.044 3.365 1.00 63.63 ? 2 NAG C O4 1 HETATM 6711 O O5 . NAG K 2 . ? 81.441 -38.649 3.094 1.00 62.74 ? 2 NAG C O5 1 HETATM 6712 O O6 . NAG K 2 . ? 81.089 -38.566 5.525 1.00 61.44 ? 2 NAG C O6 1 HETATM 6713 O O7 . NAG K 2 . ? 78.964 -37.798 -1.207 1.00 59.74 ? 2 NAG C O7 1 HETATM 6714 C C1 . BMA L 3 . ? 81.018 -33.963 3.747 1.00 64.73 ? 3 BMA C C1 1 HETATM 6715 C C2 . BMA L 3 . ? 81.734 -33.119 4.807 1.00 65.37 ? 3 BMA C C2 1 HETATM 6716 C C3 . BMA L 3 . ? 80.847 -31.977 5.284 1.00 66.61 ? 3 BMA C C3 1 HETATM 6717 C C4 . BMA L 3 . ? 80.340 -31.230 4.058 1.00 65.75 ? 3 BMA C C4 1 HETATM 6718 C C5 . BMA L 3 . ? 79.711 -32.122 2.992 1.00 64.87 ? 3 BMA C C5 1 HETATM 6719 C C6 . BMA L 3 . ? 79.217 -31.233 1.845 1.00 63.90 ? 3 BMA C C6 1 HETATM 6720 O O2 . BMA L 3 . ? 82.947 -32.600 4.318 1.00 64.82 ? 3 BMA C O2 1 HETATM 6721 O O3 . BMA L 3 . ? 81.579 -30.982 5.978 1.00 69.36 ? 3 BMA C O3 1 HETATM 6722 O O4 . BMA L 3 . ? 79.440 -30.213 4.441 1.00 65.13 ? 3 BMA C O4 1 HETATM 6723 O O5 . BMA L 3 . ? 80.590 -33.181 2.647 1.00 64.31 ? 3 BMA C O5 1 HETATM 6724 O O6 . BMA L 3 . ? 79.049 -31.904 0.618 1.00 63.07 ? 3 BMA C O6 1 HETATM 6725 C C1 . MAN M 4 . ? 80.244 -31.895 -0.179 1.00 62.35 ? 4 MAN C C1 1 HETATM 6726 C C2 . MAN M 4 . ? 81.172 -30.713 0.146 1.00 62.13 ? 4 MAN C C2 1 HETATM 6727 C C3 . MAN M 4 . ? 80.601 -29.395 -0.369 1.00 61.81 ? 4 MAN C C3 1 HETATM 6728 C C4 . MAN M 4 . ? 80.221 -29.600 -1.820 1.00 61.41 ? 4 MAN C C4 1 HETATM 6729 C C5 . MAN M 4 . ? 79.280 -30.783 -2.046 1.00 61.61 ? 4 MAN C C5 1 HETATM 6730 C C6 . MAN M 4 . ? 79.002 -30.953 -3.547 1.00 62.40 ? 4 MAN C C6 1 HETATM 6731 O O2 . MAN M 4 . ? 82.455 -30.928 -0.407 1.00 61.28 ? 4 MAN C O2 1 HETATM 6732 O O3 . MAN M 4 . ? 81.531 -28.324 -0.298 1.00 60.81 ? 4 MAN C O3 1 HETATM 6733 O O4 . MAN M 4 . ? 79.644 -28.389 -2.232 1.00 61.59 ? 4 MAN C O4 1 HETATM 6734 O O5 . MAN M 4 . ? 79.856 -31.960 -1.533 1.00 61.45 ? 4 MAN C O5 1 HETATM 6735 O O6 . MAN M 4 . ? 78.754 -32.278 -3.968 1.00 61.77 ? 4 MAN C O6 1 HETATM 6736 C C1 . MAN N 4 . ? 82.513 -31.466 6.966 1.00 72.50 ? 5 MAN C C1 1 HETATM 6737 C C2 . MAN N 4 . ? 81.803 -31.794 8.273 1.00 73.48 ? 5 MAN C C2 1 HETATM 6738 C C3 . MAN N 4 . ? 81.104 -30.548 8.816 1.00 74.80 ? 5 MAN C C3 1 HETATM 6739 C C4 . MAN N 4 . ? 82.168 -29.481 9.039 1.00 74.98 ? 5 MAN C C4 1 HETATM 6740 C C5 . MAN N 4 . ? 82.919 -29.291 7.724 1.00 74.91 ? 5 MAN C C5 1 HETATM 6741 C C6 . MAN N 4 . ? 83.985 -28.215 7.849 1.00 75.22 ? 5 MAN C C6 1 HETATM 6742 O O2 . MAN N 4 . ? 82.796 -32.207 9.184 1.00 72.53 ? 5 MAN C O2 1 HETATM 6743 O O3 . MAN N 4 . ? 80.452 -30.822 10.040 1.00 75.30 ? 5 MAN C O3 1 HETATM 6744 O O4 . MAN N 4 . ? 81.587 -28.273 9.499 1.00 74.95 ? 5 MAN C O4 1 HETATM 6745 O O5 . MAN N 4 . ? 83.497 -30.502 7.278 1.00 73.62 ? 5 MAN C O5 1 HETATM 6746 O O6 . MAN N 4 . ? 83.358 -26.993 7.523 1.00 75.15 ? 5 MAN C O6 1 HETATM 6747 N N . NH4 O 5 . ? 74.308 -25.917 -1.922 1.00 26.67 ? 548 NH4 C N 1 HETATM 6748 C C1 . NAG P 2 . ? 83.949 -30.681 16.914 1.00 59.74 ? 1 NAG D C1 1 HETATM 6749 C C2 . NAG P 2 . ? 83.691 -31.535 15.676 1.00 60.48 ? 1 NAG D C2 1 HETATM 6750 C C3 . NAG P 2 . ? 84.804 -32.560 15.505 1.00 61.48 ? 1 NAG D C3 1 HETATM 6751 C C4 . NAG P 2 . ? 86.141 -31.829 15.427 1.00 61.82 ? 1 NAG D C4 1 HETATM 6752 C C5 . NAG P 2 . ? 86.295 -30.858 16.590 1.00 60.74 ? 1 NAG D C5 1 HETATM 6753 C C6 . NAG P 2 . ? 87.547 -30.029 16.345 1.00 60.53 ? 1 NAG D C6 1 HETATM 6754 C C7 . NAG P 2 . ? 81.425 -31.848 14.845 1.00 59.58 ? 1 NAG D C7 1 HETATM 6755 C C8 . NAG P 2 . ? 80.124 -32.586 14.984 1.00 59.06 ? 1 NAG D C8 1 HETATM 6756 N N2 . NAG P 2 . ? 82.389 -32.174 15.711 1.00 60.31 ? 1 NAG D N2 1 HETATM 6757 O O3 . NAG P 2 . ? 84.591 -33.315 14.332 1.00 61.31 ? 1 NAG D O3 1 HETATM 6758 O O4 . NAG P 2 . ? 87.217 -32.745 15.454 1.00 63.52 ? 1 NAG D O4 1 HETATM 6759 O O5 . NAG P 2 . ? 85.172 -30.011 16.683 1.00 60.29 ? 1 NAG D O5 1 HETATM 6760 O O6 . NAG P 2 . ? 87.336 -28.665 16.615 1.00 60.57 ? 1 NAG D O6 1 HETATM 6761 O O7 . NAG P 2 . ? 81.563 -30.997 13.966 1.00 58.43 ? 1 NAG D O7 1 HETATM 6762 C C1 . NAG Q 2 . ? 87.864 -32.785 14.166 1.00 65.09 ? 2 NAG D C1 1 HETATM 6763 C C2 . NAG Q 2 . ? 89.373 -32.851 14.344 1.00 65.29 ? 2 NAG D C2 1 HETATM 6764 C C3 . NAG Q 2 . ? 90.043 -32.815 12.982 1.00 65.40 ? 2 NAG D C3 1 HETATM 6765 C C4 . NAG Q 2 . ? 89.484 -33.900 12.065 1.00 66.18 ? 2 NAG D C4 1 HETATM 6766 C C5 . NAG Q 2 . ? 87.952 -33.916 12.082 1.00 66.14 ? 2 NAG D C5 1 HETATM 6767 C C6 . NAG Q 2 . ? 87.345 -35.133 11.382 1.00 66.25 ? 2 NAG D C6 1 HETATM 6768 C C7 . NAG Q 2 . ? 90.697 -31.720 16.025 1.00 66.50 ? 2 NAG D C7 1 HETATM 6769 C C8 . NAG Q 2 . ? 91.068 -30.414 16.663 1.00 65.94 ? 2 NAG D C8 1 HETATM 6770 N N2 . NAG Q 2 . ? 89.811 -31.663 15.043 1.00 65.93 ? 2 NAG D N2 1 HETATM 6771 O O3 . NAG Q 2 . ? 91.432 -32.964 13.183 1.00 64.56 ? 2 NAG D O3 1 HETATM 6772 O O4 . NAG Q 2 . ? 89.948 -33.664 10.751 1.00 66.88 ? 2 NAG D O4 1 HETATM 6773 O O5 . NAG Q 2 . ? 87.443 -33.891 13.400 1.00 65.89 ? 2 NAG D O5 1 HETATM 6774 O O6 . NAG Q 2 . ? 86.879 -36.055 12.348 1.00 66.12 ? 2 NAG D O6 1 HETATM 6775 O O7 . NAG Q 2 . ? 91.198 -32.777 16.396 1.00 67.51 ? 2 NAG D O7 1 HETATM 6776 C C1 . BMA R 3 . ? 90.860 -34.692 10.307 1.00 67.76 ? 3 BMA D C1 1 HETATM 6777 C C2 . BMA R 3 . ? 90.929 -34.665 8.781 1.00 68.54 ? 3 BMA D C2 1 HETATM 6778 C C3 . BMA R 3 . ? 91.787 -35.808 8.255 1.00 69.69 ? 3 BMA D C3 1 HETATM 6779 C C4 . BMA R 3 . ? 93.141 -35.686 8.925 1.00 69.58 ? 3 BMA D C4 1 HETATM 6780 C C5 . BMA R 3 . ? 93.010 -35.600 10.438 1.00 69.43 ? 3 BMA D C5 1 HETATM 6781 C C6 . BMA R 3 . ? 94.401 -35.505 11.048 1.00 70.21 ? 3 BMA D C6 1 HETATM 6782 O O2 . BMA R 3 . ? 91.481 -33.445 8.338 1.00 67.62 ? 3 BMA D O2 1 HETATM 6783 O O3 . BMA R 3 . ? 92.025 -35.638 6.874 1.00 71.52 ? 3 BMA D O3 1 HETATM 6784 O O4 . BMA R 3 . ? 93.917 -36.810 8.584 1.00 69.60 ? 3 BMA D O4 1 HETATM 6785 O O5 . BMA R 3 . ? 92.162 -34.546 10.837 1.00 67.71 ? 3 BMA D O5 1 HETATM 6786 O O6 . BMA R 3 . ? 94.661 -34.199 11.509 1.00 72.61 ? 3 BMA D O6 1 HETATM 6787 C C1 . MAN S 4 . ? 95.071 -33.222 10.524 1.00 74.45 ? 4 MAN D C1 1 HETATM 6788 C C2 . MAN S 4 . ? 96.180 -33.729 9.613 1.00 75.26 ? 4 MAN D C2 1 HETATM 6789 C C3 . MAN S 4 . ? 97.295 -34.228 10.518 1.00 76.04 ? 4 MAN D C3 1 HETATM 6790 C C4 . MAN S 4 . ? 97.736 -33.106 11.465 1.00 76.18 ? 4 MAN D C4 1 HETATM 6791 C C5 . MAN S 4 . ? 96.557 -32.386 12.117 1.00 75.50 ? 4 MAN D C5 1 HETATM 6792 C C6 . MAN S 4 . ? 96.979 -31.130 12.882 1.00 75.91 ? 4 MAN D C6 1 HETATM 6793 O O2 . MAN S 4 . ? 96.669 -32.696 8.776 1.00 74.81 ? 4 MAN D O2 1 HETATM 6794 O O3 . MAN S 4 . ? 98.338 -34.740 9.708 1.00 76.28 ? 4 MAN D O3 1 HETATM 6795 O O4 . MAN S 4 . ? 98.516 -33.680 12.494 1.00 77.15 ? 4 MAN D O4 1 HETATM 6796 O O5 . MAN S 4 . ? 95.589 -32.062 11.142 1.00 74.74 ? 4 MAN D O5 1 HETATM 6797 O O6 . MAN S 4 . ? 97.033 -31.344 14.283 1.00 75.16 ? 4 MAN D O6 1 HETATM 6798 C C1 . MAN T 4 . ? 91.787 -36.828 6.090 1.00 72.86 ? 5 MAN D C1 1 HETATM 6799 C C2 . MAN T 4 . ? 92.502 -36.619 4.761 1.00 73.19 ? 5 MAN D C2 1 HETATM 6800 C C3 . MAN T 4 . ? 91.876 -35.383 4.110 1.00 73.81 ? 5 MAN D C3 1 HETATM 6801 C C4 . MAN T 4 . ? 90.375 -35.594 3.929 1.00 73.96 ? 5 MAN D C4 1 HETATM 6802 C C5 . MAN T 4 . ? 89.765 -35.951 5.283 1.00 73.71 ? 5 MAN D C5 1 HETATM 6803 C C6 . MAN T 4 . ? 88.251 -36.142 5.239 1.00 73.77 ? 5 MAN D C6 1 HETATM 6804 O O2 . MAN T 4 . ? 92.366 -37.791 3.992 1.00 72.80 ? 5 MAN D O2 1 HETATM 6805 O O3 . MAN T 4 . ? 92.517 -34.989 2.913 1.00 73.88 ? 5 MAN D O3 1 HETATM 6806 O O4 . MAN T 4 . ? 89.796 -34.398 3.460 1.00 74.12 ? 5 MAN D O4 1 HETATM 6807 O O5 . MAN T 4 . ? 90.416 -37.081 5.830 1.00 73.19 ? 5 MAN D O5 1 HETATM 6808 O O6 . MAN T 4 . ? 87.710 -35.617 6.432 1.00 73.87 ? 5 MAN D O6 1 HETATM 6809 O O . HOH U 6 . ? 112.611 -17.939 36.283 1.00 24.03 ? 5 HOH A O 1 HETATM 6810 O O . HOH U 6 . ? 88.386 -28.313 42.398 1.00 27.16 ? 6 HOH A O 1 HETATM 6811 O O . HOH U 6 . ? 99.903 -22.448 32.666 1.00 20.29 ? 8 HOH A O 1 HETATM 6812 O O . HOH U 6 . ? 88.128 -17.161 34.721 1.00 20.01 ? 9 HOH A O 1 HETATM 6813 O O . HOH U 6 . ? 121.837 -22.302 28.585 1.00 41.53 ? 32 HOH A O 1 HETATM 6814 O O . HOH U 6 . ? 128.970 -7.066 27.594 1.00 20.90 ? 37 HOH A O 1 HETATM 6815 O O . HOH U 6 . ? 121.929 -21.147 25.728 1.00 23.19 ? 50 HOH A O 1 HETATM 6816 O O . HOH U 6 . ? 101.453 -8.445 43.706 1.00 39.26 ? 53 HOH A O 1 HETATM 6817 O O . HOH U 6 . ? 101.613 -14.398 37.640 1.00 28.55 ? 55 HOH A O 1 HETATM 6818 O O . HOH U 6 . ? 123.971 -4.029 31.365 1.00 47.66 ? 59 HOH A O 1 HETATM 6819 O O . HOH U 6 . ? 110.302 -16.685 31.540 1.00 30.03 ? 60 HOH A O 1 HETATM 6820 O O . HOH U 6 . ? 128.477 -21.917 17.119 1.00 37.01 ? 68 HOH A O 1 HETATM 6821 O O . HOH U 6 . ? 119.185 -25.273 31.457 1.00 38.02 ? 80 HOH A O 1 HETATM 6822 O O . HOH U 6 . ? 102.588 -1.747 35.902 1.00 38.70 ? 89 HOH A O 1 HETATM 6823 O O . HOH U 6 . ? 86.583 -15.477 44.347 1.00 23.57 ? 90 HOH A O 1 HETATM 6824 O O . HOH U 6 . ? 83.559 -23.167 39.661 1.00 26.84 ? 95 HOH A O 1 HETATM 6825 O O . HOH U 6 . ? 83.533 -13.795 35.893 1.00 37.19 ? 96 HOH A O 1 HETATM 6826 O O . HOH U 6 . ? 105.413 -40.701 46.891 1.00 34.81 ? 98 HOH A O 1 HETATM 6827 O O . HOH U 6 . ? 117.787 -14.775 14.559 1.00 34.89 ? 99 HOH A O 1 HETATM 6828 O O . HOH U 6 . ? 112.062 -3.472 21.226 1.00 30.23 ? 126 HOH A O 1 HETATM 6829 O O . HOH U 6 . ? 112.825 -1.011 35.946 1.00 27.40 ? 137 HOH A O 1 HETATM 6830 O O . HOH U 6 . ? 129.886 -22.653 24.809 1.00 32.25 ? 139 HOH A O 1 HETATM 6831 O O . HOH U 6 . ? 112.999 -1.135 29.049 1.00 24.96 ? 144 HOH A O 1 HETATM 6832 O O . HOH U 6 . ? 87.962 -12.232 33.395 1.00 27.18 ? 168 HOH A O 1 HETATM 6833 O O . HOH U 6 . ? 118.244 -16.691 40.353 1.00 26.80 ? 176 HOH A O 1 HETATM 6834 O O . HOH U 6 . ? 115.371 -7.438 19.089 1.00 43.86 ? 181 HOH A O 1 HETATM 6835 O O . HOH U 6 . ? 108.459 -17.026 37.529 1.00 41.66 ? 188 HOH A O 1 HETATM 6836 O O . HOH U 6 . ? 132.749 -16.787 25.108 1.00 32.88 ? 195 HOH A O 1 HETATM 6837 O O . HOH U 6 . ? 112.671 -15.968 24.081 1.00 27.81 ? 209 HOH A O 1 HETATM 6838 O O . HOH U 6 . ? 114.745 -21.834 31.246 1.00 30.33 ? 214 HOH A O 1 HETATM 6839 O O . HOH U 6 . ? 104.849 -10.527 37.416 1.00 35.03 ? 229 HOH A O 1 HETATM 6840 O O . HOH V 6 . ? 129.215 -31.644 54.504 1.00 18.69 ? 10 HOH B O 1 HETATM 6841 O O . HOH V 6 . ? 130.132 -21.936 46.247 1.00 24.20 ? 14 HOH B O 1 HETATM 6842 O O . HOH V 6 . ? 123.743 0.706 41.490 1.00 36.86 ? 19 HOH B O 1 HETATM 6843 O O . HOH V 6 . ? 128.631 -43.786 62.331 1.00 31.85 ? 20 HOH B O 1 HETATM 6844 O O . HOH V 6 . ? 141.491 -11.490 35.302 1.00 35.11 ? 22 HOH B O 1 HETATM 6845 O O . HOH V 6 . ? 143.442 -19.939 39.026 1.00 34.03 ? 29 HOH B O 1 HETATM 6846 O O . HOH V 6 . ? 125.255 -19.401 47.507 1.00 38.70 ? 30 HOH B O 1 HETATM 6847 O O . HOH V 6 . ? 137.965 -41.470 54.695 1.00 32.99 ? 36 HOH B O 1 HETATM 6848 O O . HOH V 6 . ? 132.855 -30.259 52.326 1.00 21.88 ? 39 HOH B O 1 HETATM 6849 O O . HOH V 6 . ? 137.609 -32.988 57.114 1.00 25.49 ? 41 HOH B O 1 HETATM 6850 O O . HOH V 6 . ? 141.771 -19.018 49.479 1.00 29.05 ? 51 HOH B O 1 HETATM 6851 O O . HOH V 6 . ? 141.686 2.123 45.789 1.00 58.39 ? 54 HOH B O 1 HETATM 6852 O O . HOH V 6 . ? 133.839 -35.335 44.048 1.00 26.61 ? 57 HOH B O 1 HETATM 6853 O O . HOH V 6 . ? 134.550 -29.970 41.415 1.00 18.96 ? 66 HOH B O 1 HETATM 6854 O O . HOH V 6 . ? 135.831 -24.669 27.556 1.00 30.33 ? 72 HOH B O 1 HETATM 6855 O O . HOH V 6 . ? 123.601 3.442 47.259 1.00 45.66 ? 76 HOH B O 1 HETATM 6856 O O . HOH V 6 . ? 133.601 6.226 42.929 1.00 43.65 ? 83 HOH B O 1 HETATM 6857 O O . HOH V 6 . ? 144.081 -26.609 56.118 1.00 35.92 ? 85 HOH B O 1 HETATM 6858 O O . HOH V 6 . ? 130.631 -24.357 47.582 1.00 26.52 ? 100 HOH B O 1 HETATM 6859 O O . HOH V 6 . ? 133.256 -7.483 32.396 1.00 27.66 ? 104 HOH B O 1 HETATM 6860 O O . HOH V 6 . ? 138.351 -42.967 62.683 1.00 51.07 ? 106 HOH B O 1 HETATM 6861 O O . HOH V 6 . ? 133.335 -48.759 57.215 1.00 29.67 ? 111 HOH B O 1 HETATM 6862 O O . HOH V 6 . ? 135.399 -40.726 58.041 1.00 17.01 ? 116 HOH B O 1 HETATM 6863 O O . HOH V 6 . ? 126.335 -47.308 57.281 1.00 36.22 ? 117 HOH B O 1 HETATM 6864 O O . HOH V 6 . ? 125.007 -35.756 46.726 1.00 40.77 ? 127 HOH B O 1 HETATM 6865 O O . HOH V 6 . ? 134.821 -40.647 46.133 1.00 35.70 ? 143 HOH B O 1 HETATM 6866 O O . HOH V 6 . ? 138.121 -36.471 30.791 1.00 36.58 ? 146 HOH B O 1 HETATM 6867 O O . HOH V 6 . ? 141.596 -9.736 45.890 1.00 45.05 ? 147 HOH B O 1 HETATM 6868 O O . HOH V 6 . ? 141.069 -6.313 45.701 1.00 42.88 ? 149 HOH B O 1 HETATM 6869 O O . HOH V 6 . ? 142.314 -5.921 36.971 1.00 47.71 ? 152 HOH B O 1 HETATM 6870 O O . HOH V 6 . ? 128.684 -39.544 42.688 1.00 45.36 ? 159 HOH B O 1 HETATM 6871 O O . HOH V 6 . ? 143.427 -43.245 49.879 1.00 55.89 ? 173 HOH B O 1 HETATM 6872 O O . HOH V 6 . ? 126.965 -18.048 49.306 1.00 31.01 ? 184 HOH B O 1 HETATM 6873 O O . HOH V 6 . ? 129.699 -0.169 36.979 1.00 48.29 ? 191 HOH B O 1 HETATM 6874 O O . HOH V 6 . ? 123.778 -1.754 39.636 1.00 40.73 ? 197 HOH B O 1 HETATM 6875 O O . HOH V 6 . ? 131.714 -5.621 33.360 1.00 34.14 ? 200 HOH B O 1 HETATM 6876 O O . HOH V 6 . ? 136.877 -10.514 53.846 1.00 39.40 ? 220 HOH B O 1 HETATM 6877 O O . HOH V 6 . ? 129.447 -27.619 27.367 1.00 43.83 ? 548 HOH B O 1 HETATM 6878 O O . HOH W 6 . ? 91.663 -21.325 -26.148 1.00 23.41 ? 11 HOH C O 1 HETATM 6879 O O . HOH W 6 . ? 100.102 -11.468 -11.041 1.00 25.07 ? 12 HOH C O 1 HETATM 6880 O O . HOH W 6 . ? 87.790 -14.232 -20.027 1.00 27.37 ? 13 HOH C O 1 HETATM 6881 O O . HOH W 6 . ? 81.798 -24.308 -15.567 1.00 32.58 ? 17 HOH C O 1 HETATM 6882 O O . HOH W 6 . ? 72.509 -23.298 -4.983 1.00 19.45 ? 21 HOH C O 1 HETATM 6883 O O . HOH W 6 . ? 93.361 -27.622 -15.475 1.00 27.77 ? 25 HOH C O 1 HETATM 6884 O O . HOH W 6 . ? 92.978 -25.654 -4.599 1.00 36.89 ? 26 HOH C O 1 HETATM 6885 O O . HOH W 6 . ? 68.480 -17.789 5.164 1.00 21.06 ? 27 HOH C O 1 HETATM 6886 O O . HOH W 6 . ? 74.115 -16.997 1.978 1.00 30.66 ? 28 HOH C O 1 HETATM 6887 O O . HOH W 6 . ? 72.269 -25.454 -8.699 1.00 36.03 ? 31 HOH C O 1 HETATM 6888 O O . HOH W 6 . ? 78.348 -14.916 -0.489 1.00 33.05 ? 35 HOH C O 1 HETATM 6889 O O . HOH W 6 . ? 59.670 -32.214 1.039 1.00 22.50 ? 43 HOH C O 1 HETATM 6890 O O . HOH W 6 . ? 97.166 -13.187 -26.157 1.00 21.60 ? 44 HOH C O 1 HETATM 6891 O O . HOH W 6 . ? 80.984 -14.058 -18.421 1.00 45.51 ? 47 HOH C O 1 HETATM 6892 O O . HOH W 6 . ? 90.282 -14.466 -21.373 1.00 22.35 ? 49 HOH C O 1 HETATM 6893 O O . HOH W 6 . ? 71.795 -28.719 11.205 1.00 44.90 ? 52 HOH C O 1 HETATM 6894 O O . HOH W 6 . ? 77.240 -24.710 -0.617 1.00 29.46 ? 58 HOH C O 1 HETATM 6895 O O . HOH W 6 . ? 85.162 -22.092 -13.658 1.00 22.87 ? 63 HOH C O 1 HETATM 6896 O O . HOH W 6 . ? 75.257 -17.347 4.431 1.00 29.13 ? 67 HOH C O 1 HETATM 6897 O O . HOH W 6 . ? 94.159 -27.262 -12.146 1.00 24.71 ? 73 HOH C O 1 HETATM 6898 O O . HOH W 6 . ? 81.556 -27.613 -15.395 1.00 29.39 ? 74 HOH C O 1 HETATM 6899 O O . HOH W 6 . ? 69.437 -33.925 -6.049 1.00 58.17 ? 75 HOH C O 1 HETATM 6900 O O . HOH W 6 . ? 74.072 -8.868 -1.932 1.00 36.84 ? 77 HOH C O 1 HETATM 6901 O O . HOH W 6 . ? 62.948 -35.150 -3.009 1.00 47.14 ? 78 HOH C O 1 HETATM 6902 O O . HOH W 6 . ? 73.393 -38.859 -4.522 1.00 37.89 ? 79 HOH C O 1 HETATM 6903 O O . HOH W 6 . ? 79.874 -15.574 -13.366 1.00 36.14 ? 82 HOH C O 1 HETATM 6904 O O . HOH W 6 . ? 61.387 -16.491 7.686 1.00 37.63 ? 84 HOH C O 1 HETATM 6905 O O . HOH W 6 . ? 64.016 -18.376 11.001 1.00 32.81 ? 94 HOH C O 1 HETATM 6906 O O . HOH W 6 . ? 97.128 -10.126 -12.067 1.00 26.67 ? 107 HOH C O 1 HETATM 6907 O O . HOH W 6 . ? 93.991 -27.836 -9.490 1.00 27.21 ? 108 HOH C O 1 HETATM 6908 O O . HOH W 6 . ? 94.328 -16.239 -31.169 1.00 27.89 ? 109 HOH C O 1 HETATM 6909 O O . HOH W 6 . ? 69.243 -13.342 8.505 1.00 44.48 ? 113 HOH C O 1 HETATM 6910 O O . HOH W 6 . ? 87.170 -28.179 -1.685 1.00 37.71 ? 120 HOH C O 1 HETATM 6911 O O . HOH W 6 . ? 74.692 -29.656 -4.534 1.00 48.26 ? 125 HOH C O 1 HETATM 6912 O O . HOH W 6 . ? 80.322 -21.580 -9.939 1.00 39.21 ? 134 HOH C O 1 HETATM 6913 O O . HOH W 6 . ? 78.312 -23.494 2.011 1.00 34.12 ? 145 HOH C O 1 HETATM 6914 O O . HOH W 6 . ? 99.375 -10.673 -15.879 1.00 26.24 ? 148 HOH C O 1 HETATM 6915 O O . HOH W 6 . ? 98.877 -15.858 -31.068 1.00 32.19 ? 155 HOH C O 1 HETATM 6916 O O . HOH W 6 . ? 101.864 -26.533 -14.521 1.00 32.90 ? 171 HOH C O 1 HETATM 6917 O O . HOH W 6 . ? 93.064 -27.670 -22.018 1.00 46.47 ? 192 HOH C O 1 HETATM 6918 O O . HOH W 6 . ? 100.681 -25.517 -29.236 1.00 40.06 ? 203 HOH C O 1 HETATM 6919 O O . HOH W 6 . ? 72.474 -27.098 -3.427 1.00 41.11 ? 210 HOH C O 1 HETATM 6920 O O . HOH W 6 . ? 84.716 -10.196 -17.681 1.00 38.36 ? 211 HOH C O 1 HETATM 6921 O O . HOH W 6 . ? 104.930 -19.935 -29.180 1.00 44.04 ? 218 HOH C O 1 HETATM 6922 O O . HOH W 6 . ? 69.130 -18.844 -14.591 1.00 38.39 ? 232 HOH C O 1 HETATM 6923 O O . HOH W 6 . ? 82.946 -44.180 -5.049 1.00 46.79 ? 235 HOH C O 1 HETATM 6924 O O . HOH W 6 . ? 82.285 -21.598 0.258 1.00 26.16 ? 549 HOH C O 1 HETATM 6925 O O . HOH X 6 . ? 105.363 -23.825 -13.476 1.00 29.55 ? 7 HOH D O 1 HETATM 6926 O O . HOH X 6 . ? 106.873 -36.140 13.369 1.00 22.67 ? 16 HOH D O 1 HETATM 6927 O O . HOH X 6 . ? 104.383 -39.161 2.501 1.00 30.90 ? 18 HOH D O 1 HETATM 6928 O O . HOH X 6 . ? 106.970 -9.793 -5.470 1.00 30.23 ? 45 HOH D O 1 HETATM 6929 O O . HOH X 6 . ? 115.674 -38.966 1.223 1.00 38.35 ? 46 HOH D O 1 HETATM 6930 O O . HOH X 6 . ? 110.528 -44.083 25.675 1.00 40.80 ? 48 HOH D O 1 HETATM 6931 O O . HOH X 6 . ? 98.737 -51.580 19.135 1.00 34.86 ? 69 HOH D O 1 HETATM 6932 O O . HOH X 6 . ? 105.178 -53.919 19.448 1.00 31.32 ? 81 HOH D O 1 HETATM 6933 O O . HOH X 6 . ? 111.283 -30.899 -9.503 1.00 36.52 ? 87 HOH D O 1 HETATM 6934 O O . HOH X 6 . ? 108.522 -36.059 1.922 1.00 22.74 ? 91 HOH D O 1 HETATM 6935 O O . HOH X 6 . ? 102.710 -37.040 12.665 1.00 31.28 ? 93 HOH D O 1 HETATM 6936 O O . HOH X 6 . ? 104.152 -27.957 7.462 1.00 18.74 ? 97 HOH D O 1 HETATM 6937 O O . HOH X 6 . ? 99.227 -15.731 7.637 1.00 34.79 ? 103 HOH D O 1 HETATM 6938 O O . HOH X 6 . ? 103.432 -35.765 8.057 1.00 44.16 ? 110 HOH D O 1 HETATM 6939 O O . HOH X 6 . ? 105.767 -31.920 13.172 1.00 35.96 ? 114 HOH D O 1 HETATM 6940 O O . HOH X 6 . ? 115.102 -18.194 -4.333 1.00 33.86 ? 118 HOH D O 1 HETATM 6941 O O . HOH X 6 . ? 120.738 -27.476 1.153 1.00 29.18 ? 124 HOH D O 1 HETATM 6942 O O . HOH X 6 . ? 102.400 -28.424 -13.509 1.00 39.24 ? 131 HOH D O 1 HETATM 6943 O O . HOH X 6 . ? 100.272 -35.115 12.342 1.00 44.40 ? 133 HOH D O 1 HETATM 6944 O O . HOH X 6 . ? 101.405 -39.789 -0.783 1.00 26.82 ? 151 HOH D O 1 HETATM 6945 O O . HOH X 6 . ? 117.908 -18.870 3.008 1.00 39.11 ? 157 HOH D O 1 HETATM 6946 O O . HOH X 6 . ? 110.508 -20.162 -8.751 1.00 40.46 ? 162 HOH D O 1 HETATM 6947 O O . HOH X 6 . ? 99.875 -2.681 1.434 1.00 53.86 ? 174 HOH D O 1 HETATM 6948 O O . HOH X 6 . ? 96.058 -28.480 -1.147 1.00 34.70 ? 178 HOH D O 1 HETATM 6949 O O . HOH X 6 . ? 116.557 -28.460 -3.678 1.00 31.25 ? 179 HOH D O 1 HETATM 6950 O O . HOH X 6 . ? 104.553 -8.682 12.641 1.00 59.12 ? 182 HOH D O 1 HETATM 6951 O O . HOH X 6 . ? 102.530 -32.742 6.909 1.00 40.11 ? 202 HOH D O 1 HETATM 6952 O O . HOH X 6 . ? 99.863 -36.449 21.879 1.00 44.78 ? 212 HOH D O 1 HETATM 6953 O O . HOH X 6 . ? 104.437 -3.451 -4.764 1.00 48.47 ? 231 HOH D O 1 HETATM 6954 O O . HOH X 6 . ? 115.056 -15.241 5.653 1.00 32.01 ? 548 HOH D O 1 # loop_ _pdbx_poly_seq_scheme.asym_id _pdbx_poly_seq_scheme.entity_id _pdbx_poly_seq_scheme.seq_id _pdbx_poly_seq_scheme.mon_id _pdbx_poly_seq_scheme.ndb_seq_num _pdbx_poly_seq_scheme.pdb_seq_num _pdbx_poly_seq_scheme.auth_seq_num _pdbx_poly_seq_scheme.pdb_mon_id _pdbx_poly_seq_scheme.auth_mon_id _pdbx_poly_seq_scheme.pdb_strand_id _pdbx_poly_seq_scheme.pdb_ins_code _pdbx_poly_seq_scheme.hetero A 1 1 ALA 1 325 ? ? ? A . n A 1 2 ASP 2 326 ? ? ? A . n A 1 3 PRO 3 327 ? ? ? A . n A 1 4 CYS 4 328 ? ? ? A . n A 1 5 ALA 5 329 ? ? ? A . n A 1 6 ASP 6 330 ? ? ? A . n A 1 7 SER 7 331 ? ? ? A . n A 1 8 ASN 8 332 ? ? ? A . n A 1 9 PRO 9 333 ? ? ? A . n A 1 10 ARG 10 334 ? ? ? A . n A 1 11 GLY 11 335 ? ? ? A . n A 1 12 VAL 12 336 336 VAL VAL A . n A 1 13 SER 13 337 337 SER SER A . n A 1 14 ALA 14 338 338 ALA ALA A . n A 1 15 TYR 15 339 339 TYR TYR A . n A 1 16 LEU 16 340 340 LEU LEU A . n A 1 17 SER 17 341 341 SER SER A . n A 1 18 ARG 18 342 342 ARG ARG A . n A 1 19 PRO 19 343 343 PRO PRO A . n A 1 20 SER 20 344 344 SER SER A . n A 1 21 PRO 21 345 345 PRO PRO A . n A 1 22 PHE 22 346 346 PHE PHE A . n A 1 23 ASP 23 347 347 ASP ASP A . n A 1 24 LEU 24 348 348 LEU LEU A . n A 1 25 PHE 25 349 349 PHE PHE A . n A 1 26 ILE 26 350 350 ILE ILE A . n A 1 27 ARG 27 351 351 ARG ARG A . n A 1 28 LYS 28 352 352 LYS LYS A . n A 1 29 SER 29 353 353 SER SER A . n A 1 30 PRO 30 354 354 PRO PRO A . n A 1 31 THR 31 355 355 THR THR A . n A 1 32 ILE 32 356 356 ILE ILE A . n A 1 33 THR 33 357 357 THR THR A . n A 1 34 CYS 34 358 358 CYS CYS A . n A 1 35 LEU 35 359 359 LEU LEU A . n A 1 36 VAL 36 360 360 VAL VAL A . n A 1 37 VAL 37 361 361 VAL VAL A . n A 1 38 ASP 38 362 362 ASP ASP A . n A 1 39 LEU 39 363 363 LEU LEU A . n A 1 40 ALA 40 364 364 ALA ALA A . n A 1 41 PRO 41 365 365 PRO PRO A . n A 1 42 SER 42 366 366 SER SER A . n A 1 43 LYS 43 367 367 LYS LYS A . n A 1 44 GLY 44 368 368 GLY GLY A . n A 1 45 THR 45 369 369 THR THR A . n A 1 46 VAL 46 370 370 VAL VAL A . n A 1 47 GLN 47 371 371 GLN GLN A . n A 1 48 LEU 48 372 372 LEU LEU A . n A 1 49 THR 49 373 373 THR THR A . n A 1 50 TRP 50 374 374 TRP TRP A . n A 1 51 SER 51 375 375 SER SER A . n A 1 52 ARG 52 376 376 ARG ARG A . n A 1 53 ALA 53 377 377 ALA ALA A . n A 1 54 SER 54 378 378 SER SER A . n A 1 55 GLY 55 379 379 GLY GLY A . n A 1 56 LYS 56 380 380 LYS LYS A . n A 1 57 PRO 57 381 381 PRO PRO A . n A 1 58 VAL 58 382 382 VAL VAL A . n A 1 59 GLN 59 383 383 GLN GLN A . n A 1 60 HIS 60 384 384 HIS HIS A . n A 1 61 SER 61 385 385 SER SER A . n A 1 62 THR 62 386 386 THR THR A . n A 1 63 ARG 63 387 387 ARG ARG A . n A 1 64 LYS 64 388 388 LYS LYS A . n A 1 65 GLU 65 389 389 GLU GLU A . n A 1 66 GLU 66 390 390 GLU GLU A . n A 1 67 LYS 67 391 391 LYS LYS A . n A 1 68 GLN 68 392 392 GLN GLN A . n A 1 69 ARG 69 393 393 ARG ARG A . n A 1 70 ASN 70 394 394 ASN ASN A . n A 1 71 GLY 71 395 395 GLY GLY A . n A 1 72 THR 72 396 396 THR THR A . n A 1 73 LEU 73 397 397 LEU LEU A . n A 1 74 THR 74 398 398 THR THR A . n A 1 75 VAL 75 399 399 VAL VAL A . n A 1 76 THR 76 400 400 THR THR A . n A 1 77 SER 77 401 401 SER SER A . n A 1 78 THR 78 402 402 THR THR A . n A 1 79 LEU 79 403 403 LEU LEU A . n A 1 80 PRO 80 404 404 PRO PRO A . n A 1 81 VAL 81 405 405 VAL VAL A . n A 1 82 GLY 82 406 406 GLY GLY A . n A 1 83 THR 83 407 407 THR THR A . n A 1 84 ARG 84 408 408 ARG ARG A . n A 1 85 ASP 85 409 409 ASP ASP A . n A 1 86 TRP 86 410 410 TRP TRP A . n A 1 87 ILE 87 411 411 ILE ILE A . n A 1 88 GLU 88 412 412 GLU GLU A . n A 1 89 GLY 89 413 413 GLY GLY A . n A 1 90 GLU 90 414 414 GLU GLU A . n A 1 91 THR 91 415 415 THR THR A . n A 1 92 TYR 92 416 416 TYR TYR A . n A 1 93 GLN 93 417 417 GLN GLN A . n A 1 94 CYS 94 418 418 CYS CYS A . n A 1 95 ARG 95 419 419 ARG ARG A . n A 1 96 VAL 96 420 420 VAL VAL A . n A 1 97 THR 97 421 421 THR THR A . n A 1 98 HIS 98 422 422 HIS HIS A . n A 1 99 PRO 99 423 423 PRO PRO A . n A 1 100 HIS 100 424 424 HIS HIS A . n A 1 101 LEU 101 425 425 LEU LEU A . n A 1 102 PRO 102 426 426 PRO PRO A . n A 1 103 ARG 103 427 427 ARG ARG A . n A 1 104 ALA 104 428 428 ALA ALA A . n A 1 105 LEU 105 429 429 LEU LEU A . n A 1 106 MET 106 430 430 MET MET A . n A 1 107 ARG 107 431 431 ARG ARG A . n A 1 108 SER 108 432 432 SER SER A . n A 1 109 THR 109 433 433 THR THR A . n A 1 110 THR 110 434 434 THR THR A . n A 1 111 LYS 111 435 435 LYS LYS A . n A 1 112 THR 112 436 436 THR THR A . n A 1 113 SER 113 437 437 SER SER A . n A 1 114 GLY 114 438 438 GLY GLY A . n A 1 115 PRO 115 439 439 PRO PRO A . n A 1 116 ARG 116 440 440 ARG ARG A . n A 1 117 ALA 117 441 441 ALA ALA A . n A 1 118 ALA 118 442 442 ALA ALA A . n A 1 119 PRO 119 443 443 PRO PRO A . n A 1 120 GLU 120 444 444 GLU GLU A . n A 1 121 VAL 121 445 445 VAL VAL A . n A 1 122 TYR 122 446 446 TYR TYR A . n A 1 123 ALA 123 447 447 ALA ALA A . n A 1 124 PHE 124 448 448 PHE PHE A . n A 1 125 ALA 125 449 449 ALA ALA A . n A 1 126 THR 126 450 450 THR THR A . n A 1 127 PRO 127 451 451 PRO PRO A . n A 1 128 GLU 128 452 452 GLU GLU A . n A 1 129 TRP 129 453 453 TRP TRP A . n A 1 130 PRO 130 454 454 PRO PRO A . n A 1 131 GLY 131 455 455 GLY GLY A . n A 1 132 SER 132 456 456 SER SER A . n A 1 133 ARG 133 457 457 ARG ARG A . n A 1 134 ASP 134 458 458 ASP ASP A . n A 1 135 LYS 135 459 459 LYS LYS A . n A 1 136 ARG 136 460 460 ARG ARG A . n A 1 137 THR 137 461 461 THR THR A . n A 1 138 LEU 138 462 462 LEU LEU A . n A 1 139 ALA 139 463 463 ALA ALA A . n A 1 140 CYS 140 464 464 CYS CYS A . n A 1 141 LEU 141 465 465 LEU LEU A . n A 1 142 ILE 142 466 466 ILE ILE A . n A 1 143 GLN 143 467 467 GLN GLN A . n A 1 144 ASN 144 468 468 ASN ASN A . n A 1 145 PHE 145 469 469 PHE PHE A . n A 1 146 MET 146 470 470 MET MET A . n A 1 147 PRO 147 471 471 PRO PRO A . n A 1 148 GLU 148 472 472 GLU GLU A . n A 1 149 ASP 149 473 473 ASP ASP A . n A 1 150 ILE 150 474 474 ILE ILE A . n A 1 151 SER 151 475 475 SER SER A . n A 1 152 VAL 152 476 476 VAL VAL A . n A 1 153 GLN 153 477 477 GLN GLN A . n A 1 154 TRP 154 478 478 TRP TRP A . n A 1 155 LEU 155 479 479 LEU LEU A . n A 1 156 HIS 156 480 480 HIS HIS A . n A 1 157 ASN 157 481 481 ASN ASN A . n A 1 158 GLU 158 482 482 GLU GLU A . n A 1 159 VAL 159 483 483 VAL VAL A . n A 1 160 GLN 160 484 484 GLN GLN A . n A 1 161 LEU 161 485 485 LEU LEU A . n A 1 162 PRO 162 486 486 PRO PRO A . n A 1 163 ASP 163 487 487 ASP ASP A . n A 1 164 ALA 164 488 488 ALA ALA A . n A 1 165 ARG 165 489 489 ARG ARG A . n A 1 166 HIS 166 490 490 HIS HIS A . n A 1 167 SER 167 491 491 SER SER A . n A 1 168 THR 168 492 492 THR THR A . n A 1 169 THR 169 493 493 THR THR A . n A 1 170 GLN 170 494 494 GLN GLN A . n A 1 171 PRO 171 495 495 PRO PRO A . n A 1 172 ARG 172 496 496 ARG ARG A . n A 1 173 LYS 173 497 497 LYS LYS A . n A 1 174 THR 174 498 498 THR THR A . n A 1 175 LYS 175 499 499 LYS LYS A . n A 1 176 GLY 176 500 500 GLY GLY A . n A 1 177 SER 177 501 501 SER SER A . n A 1 178 GLY 178 502 502 GLY GLY A . n A 1 179 PHE 179 503 503 PHE PHE A . n A 1 180 PHE 180 504 504 PHE PHE A . n A 1 181 VAL 181 505 505 VAL VAL A . n A 1 182 PHE 182 506 506 PHE PHE A . n A 1 183 SER 183 507 507 SER SER A . n A 1 184 ARG 184 508 508 ARG ARG A . n A 1 185 LEU 185 509 509 LEU LEU A . n A 1 186 GLU 186 510 510 GLU GLU A . n A 1 187 VAL 187 511 511 VAL VAL A . n A 1 188 THR 188 512 512 THR THR A . n A 1 189 ARG 189 513 513 ARG ARG A . n A 1 190 ALA 190 514 514 ALA ALA A . n A 1 191 GLU 191 515 515 GLU GLU A . n A 1 192 TRP 192 516 516 TRP TRP A . n A 1 193 GLU 193 517 517 GLU GLU A . n A 1 194 GLN 194 518 518 GLN GLN A . n A 1 195 LYS 195 519 519 LYS LYS A . n A 1 196 ASP 196 520 520 ASP ASP A . n A 1 197 GLU 197 521 521 GLU GLU A . n A 1 198 PHE 198 522 522 PHE PHE A . n A 1 199 ILE 199 523 523 ILE ILE A . n A 1 200 CYS 200 524 524 CYS CYS A . n A 1 201 ARG 201 525 525 ARG ARG A . n A 1 202 ALA 202 526 526 ALA ALA A . n A 1 203 VAL 203 527 527 VAL VAL A . n A 1 204 HIS 204 528 528 HIS HIS A . n A 1 205 GLU 205 529 529 GLU GLU A . n A 1 206 ALA 206 530 530 ALA ALA A . n A 1 207 ALA 207 531 531 ALA ALA A . n A 1 208 SER 208 532 532 SER SER A . n A 1 209 PRO 209 533 533 PRO PRO A . n A 1 210 SER 210 534 534 SER SER A . n A 1 211 GLN 211 535 535 GLN GLN A . n A 1 212 THR 212 536 536 THR THR A . n A 1 213 VAL 213 537 537 VAL VAL A . n A 1 214 GLN 214 538 538 GLN GLN A . n A 1 215 ARG 215 539 539 ARG ARG A . n A 1 216 ALA 216 540 540 ALA ALA A . n A 1 217 VAL 217 541 541 VAL VAL A . n A 1 218 SER 218 542 542 SER SER A . n A 1 219 VAL 219 543 543 VAL VAL A . n A 1 220 ASN 220 544 544 ASN ASN A . n A 1 221 PRO 221 545 ? ? ? A . n A 1 222 GLY 222 546 ? ? ? A . n A 1 223 LYS 223 547 ? ? ? A . n B 1 1 ALA 1 325 ? ? ? B . n B 1 2 ASP 2 326 ? ? ? B . n B 1 3 PRO 3 327 ? ? ? B . n B 1 4 CYS 4 328 ? ? ? B . n B 1 5 ALA 5 329 ? ? ? B . n B 1 6 ASP 6 330 ? ? ? B . n B 1 7 SER 7 331 ? ? ? B . n B 1 8 ASN 8 332 ? ? ? B . n B 1 9 PRO 9 333 ? ? ? B . n B 1 10 ARG 10 334 ? ? ? B . n B 1 11 GLY 11 335 ? ? ? B . n B 1 12 VAL 12 336 336 VAL VAL B . n B 1 13 SER 13 337 337 SER SER B . n B 1 14 ALA 14 338 338 ALA ALA B . n B 1 15 TYR 15 339 339 TYR TYR B . n B 1 16 LEU 16 340 340 LEU LEU B . n B 1 17 SER 17 341 341 SER SER B . n B 1 18 ARG 18 342 342 ARG ARG B . n B 1 19 PRO 19 343 343 PRO PRO B . n B 1 20 SER 20 344 344 SER SER B . n B 1 21 PRO 21 345 345 PRO PRO B . n B 1 22 PHE 22 346 346 PHE PHE B . n B 1 23 ASP 23 347 347 ASP ASP B . n B 1 24 LEU 24 348 348 LEU LEU B . n B 1 25 PHE 25 349 349 PHE PHE B . n B 1 26 ILE 26 350 350 ILE ILE B . n B 1 27 ARG 27 351 351 ARG ARG B . n B 1 28 LYS 28 352 352 LYS LYS B . n B 1 29 SER 29 353 353 SER SER B . n B 1 30 PRO 30 354 354 PRO PRO B . n B 1 31 THR 31 355 355 THR THR B . n B 1 32 ILE 32 356 356 ILE ILE B . n B 1 33 THR 33 357 357 THR THR B . n B 1 34 CYS 34 358 358 CYS CYS B . n B 1 35 LEU 35 359 359 LEU LEU B . n B 1 36 VAL 36 360 360 VAL VAL B . n B 1 37 VAL 37 361 361 VAL VAL B . n B 1 38 ASP 38 362 362 ASP ASP B . n B 1 39 LEU 39 363 363 LEU LEU B . n B 1 40 ALA 40 364 364 ALA ALA B . n B 1 41 PRO 41 365 365 PRO PRO B . n B 1 42 SER 42 366 366 SER SER B . n B 1 43 LYS 43 367 367 LYS LYS B . n B 1 44 GLY 44 368 368 GLY GLY B . n B 1 45 THR 45 369 369 THR THR B . n B 1 46 VAL 46 370 370 VAL VAL B . n B 1 47 GLN 47 371 371 GLN GLN B . n B 1 48 LEU 48 372 372 LEU LEU B . n B 1 49 THR 49 373 373 THR THR B . n B 1 50 TRP 50 374 374 TRP TRP B . n B 1 51 SER 51 375 375 SER SER B . n B 1 52 ARG 52 376 376 ARG ARG B . n B 1 53 ALA 53 377 377 ALA ALA B . n B 1 54 SER 54 378 378 SER SER B . n B 1 55 GLY 55 379 379 GLY GLY B . n B 1 56 LYS 56 380 380 LYS LYS B . n B 1 57 PRO 57 381 381 PRO PRO B . n B 1 58 VAL 58 382 382 VAL VAL B . n B 1 59 GLN 59 383 383 GLN GLN B . n B 1 60 HIS 60 384 384 HIS HIS B . n B 1 61 SER 61 385 385 SER SER B . n B 1 62 THR 62 386 386 THR THR B . n B 1 63 ARG 63 387 387 ARG ARG B . n B 1 64 LYS 64 388 388 LYS LYS B . n B 1 65 GLU 65 389 389 GLU GLU B . n B 1 66 GLU 66 390 390 GLU GLU B . n B 1 67 LYS 67 391 391 LYS LYS B . n B 1 68 GLN 68 392 392 GLN GLN B . n B 1 69 ARG 69 393 393 ARG ARG B . n B 1 70 ASN 70 394 394 ASN ASN B . n B 1 71 GLY 71 395 395 GLY GLY B . n B 1 72 THR 72 396 396 THR THR B . n B 1 73 LEU 73 397 397 LEU LEU B . n B 1 74 THR 74 398 398 THR THR B . n B 1 75 VAL 75 399 399 VAL VAL B . n B 1 76 THR 76 400 400 THR THR B . n B 1 77 SER 77 401 401 SER SER B . n B 1 78 THR 78 402 402 THR THR B . n B 1 79 LEU 79 403 403 LEU LEU B . n B 1 80 PRO 80 404 404 PRO PRO B . n B 1 81 VAL 81 405 405 VAL VAL B . n B 1 82 GLY 82 406 406 GLY GLY B . n B 1 83 THR 83 407 407 THR THR B . n B 1 84 ARG 84 408 408 ARG ARG B . n B 1 85 ASP 85 409 409 ASP ASP B . n B 1 86 TRP 86 410 410 TRP TRP B . n B 1 87 ILE 87 411 411 ILE ILE B . n B 1 88 GLU 88 412 412 GLU GLU B . n B 1 89 GLY 89 413 413 GLY GLY B . n B 1 90 GLU 90 414 414 GLU GLU B . n B 1 91 THR 91 415 415 THR THR B . n B 1 92 TYR 92 416 416 TYR TYR B . n B 1 93 GLN 93 417 417 GLN GLN B . n B 1 94 CYS 94 418 418 CYS CYS B . n B 1 95 ARG 95 419 419 ARG ARG B . n B 1 96 VAL 96 420 420 VAL VAL B . n B 1 97 THR 97 421 421 THR THR B . n B 1 98 HIS 98 422 422 HIS HIS B . n B 1 99 PRO 99 423 423 PRO PRO B . n B 1 100 HIS 100 424 424 HIS HIS B . n B 1 101 LEU 101 425 425 LEU LEU B . n B 1 102 PRO 102 426 426 PRO PRO B . n B 1 103 ARG 103 427 427 ARG ARG B . n B 1 104 ALA 104 428 428 ALA ALA B . n B 1 105 LEU 105 429 429 LEU LEU B . n B 1 106 MET 106 430 430 MET MET B . n B 1 107 ARG 107 431 431 ARG ARG B . n B 1 108 SER 108 432 432 SER SER B . n B 1 109 THR 109 433 433 THR THR B . n B 1 110 THR 110 434 434 THR THR B . n B 1 111 LYS 111 435 435 LYS LYS B . n B 1 112 THR 112 436 436 THR THR B . n B 1 113 SER 113 437 437 SER SER B . n B 1 114 GLY 114 438 438 GLY GLY B . n B 1 115 PRO 115 439 439 PRO PRO B . n B 1 116 ARG 116 440 440 ARG ARG B . n B 1 117 ALA 117 441 441 ALA ALA B . n B 1 118 ALA 118 442 442 ALA ALA B . n B 1 119 PRO 119 443 443 PRO PRO B . n B 1 120 GLU 120 444 444 GLU GLU B . n B 1 121 VAL 121 445 445 VAL VAL B . n B 1 122 TYR 122 446 446 TYR TYR B . n B 1 123 ALA 123 447 447 ALA ALA B . n B 1 124 PHE 124 448 448 PHE PHE B . n B 1 125 ALA 125 449 449 ALA ALA B . n B 1 126 THR 126 450 450 THR THR B . n B 1 127 PRO 127 451 451 PRO PRO B . n B 1 128 GLU 128 452 452 GLU GLU B . n B 1 129 TRP 129 453 453 TRP TRP B . n B 1 130 PRO 130 454 454 PRO PRO B . n B 1 131 GLY 131 455 455 GLY GLY B . n B 1 132 SER 132 456 456 SER SER B . n B 1 133 ARG 133 457 457 ARG ARG B . n B 1 134 ASP 134 458 458 ASP ASP B . n B 1 135 LYS 135 459 459 LYS LYS B . n B 1 136 ARG 136 460 460 ARG ARG B . n B 1 137 THR 137 461 461 THR THR B . n B 1 138 LEU 138 462 462 LEU LEU B . n B 1 139 ALA 139 463 463 ALA ALA B . n B 1 140 CYS 140 464 464 CYS CYS B . n B 1 141 LEU 141 465 465 LEU LEU B . n B 1 142 ILE 142 466 466 ILE ILE B . n B 1 143 GLN 143 467 467 GLN GLN B . n B 1 144 ASN 144 468 468 ASN ASN B . n B 1 145 PHE 145 469 469 PHE PHE B . n B 1 146 MET 146 470 470 MET MET B . n B 1 147 PRO 147 471 471 PRO PRO B . n B 1 148 GLU 148 472 472 GLU GLU B . n B 1 149 ASP 149 473 473 ASP ASP B . n B 1 150 ILE 150 474 474 ILE ILE B . n B 1 151 SER 151 475 475 SER SER B . n B 1 152 VAL 152 476 476 VAL VAL B . n B 1 153 GLN 153 477 477 GLN GLN B . n B 1 154 TRP 154 478 478 TRP TRP B . n B 1 155 LEU 155 479 479 LEU LEU B . n B 1 156 HIS 156 480 480 HIS HIS B . n B 1 157 ASN 157 481 481 ASN ASN B . n B 1 158 GLU 158 482 482 GLU GLU B . n B 1 159 VAL 159 483 483 VAL VAL B . n B 1 160 GLN 160 484 484 GLN GLN B . n B 1 161 LEU 161 485 485 LEU LEU B . n B 1 162 PRO 162 486 486 PRO PRO B . n B 1 163 ASP 163 487 487 ASP ASP B . n B 1 164 ALA 164 488 488 ALA ALA B . n B 1 165 ARG 165 489 489 ARG ARG B . n B 1 166 HIS 166 490 490 HIS HIS B . n B 1 167 SER 167 491 491 SER SER B . n B 1 168 THR 168 492 492 THR THR B . n B 1 169 THR 169 493 493 THR THR B . n B 1 170 GLN 170 494 494 GLN GLN B . n B 1 171 PRO 171 495 495 PRO PRO B . n B 1 172 ARG 172 496 496 ARG ARG B . n B 1 173 LYS 173 497 497 LYS LYS B . n B 1 174 THR 174 498 498 THR THR B . n B 1 175 LYS 175 499 499 LYS LYS B . n B 1 176 GLY 176 500 500 GLY GLY B . n B 1 177 SER 177 501 501 SER SER B . n B 1 178 GLY 178 502 502 GLY GLY B . n B 1 179 PHE 179 503 503 PHE PHE B . n B 1 180 PHE 180 504 504 PHE PHE B . n B 1 181 VAL 181 505 505 VAL VAL B . n B 1 182 PHE 182 506 506 PHE PHE B . n B 1 183 SER 183 507 507 SER SER B . n B 1 184 ARG 184 508 508 ARG ARG B . n B 1 185 LEU 185 509 509 LEU LEU B . n B 1 186 GLU 186 510 510 GLU GLU B . n B 1 187 VAL 187 511 511 VAL VAL B . n B 1 188 THR 188 512 512 THR THR B . n B 1 189 ARG 189 513 513 ARG ARG B . n B 1 190 ALA 190 514 514 ALA ALA B . n B 1 191 GLU 191 515 515 GLU GLU B . n B 1 192 TRP 192 516 516 TRP TRP B . n B 1 193 GLU 193 517 517 GLU GLU B . n B 1 194 GLN 194 518 518 GLN GLN B . n B 1 195 LYS 195 519 519 LYS LYS B . n B 1 196 ASP 196 520 520 ASP ASP B . n B 1 197 GLU 197 521 521 GLU GLU B . n B 1 198 PHE 198 522 522 PHE PHE B . n B 1 199 ILE 199 523 523 ILE ILE B . n B 1 200 CYS 200 524 524 CYS CYS B . n B 1 201 ARG 201 525 525 ARG ARG B . n B 1 202 ALA 202 526 526 ALA ALA B . n B 1 203 VAL 203 527 527 VAL VAL B . n B 1 204 HIS 204 528 528 HIS HIS B . n B 1 205 GLU 205 529 529 GLU GLU B . n B 1 206 ALA 206 530 530 ALA ALA B . n B 1 207 ALA 207 531 531 ALA ALA B . n B 1 208 SER 208 532 532 SER SER B . n B 1 209 PRO 209 533 533 PRO PRO B . n B 1 210 SER 210 534 534 SER SER B . n B 1 211 GLN 211 535 535 GLN GLN B . n B 1 212 THR 212 536 536 THR THR B . n B 1 213 VAL 213 537 537 VAL VAL B . n B 1 214 GLN 214 538 538 GLN GLN B . n B 1 215 ARG 215 539 539 ARG ARG B . n B 1 216 ALA 216 540 540 ALA ALA B . n B 1 217 VAL 217 541 541 VAL VAL B . n B 1 218 SER 218 542 542 SER SER B . n B 1 219 VAL 219 543 543 VAL VAL B . n B 1 220 ASN 220 544 544 ASN ASN B . n B 1 221 PRO 221 545 ? ? ? B . n B 1 222 GLY 222 546 ? ? ? B . n B 1 223 LYS 223 547 ? ? ? B . n C 1 1 ALA 1 325 ? ? ? C . n C 1 2 ASP 2 326 ? ? ? C . n C 1 3 PRO 3 327 ? ? ? C . n C 1 4 CYS 4 328 ? ? ? C . n C 1 5 ALA 5 329 ? ? ? C . n C 1 6 ASP 6 330 ? ? ? C . n C 1 7 SER 7 331 ? ? ? C . n C 1 8 ASN 8 332 ? ? ? C . n C 1 9 PRO 9 333 ? ? ? C . n C 1 10 ARG 10 334 ? ? ? C . n C 1 11 GLY 11 335 ? ? ? C . n C 1 12 VAL 12 336 336 VAL VAL C . n C 1 13 SER 13 337 337 SER SER C . n C 1 14 ALA 14 338 338 ALA ALA C . n C 1 15 TYR 15 339 339 TYR TYR C . n C 1 16 LEU 16 340 340 LEU LEU C . n C 1 17 SER 17 341 341 SER SER C . n C 1 18 ARG 18 342 342 ARG ARG C . n C 1 19 PRO 19 343 343 PRO PRO C . n C 1 20 SER 20 344 344 SER SER C . n C 1 21 PRO 21 345 345 PRO PRO C . n C 1 22 PHE 22 346 346 PHE PHE C . n C 1 23 ASP 23 347 347 ASP ASP C . n C 1 24 LEU 24 348 348 LEU LEU C . n C 1 25 PHE 25 349 349 PHE PHE C . n C 1 26 ILE 26 350 350 ILE ILE C . n C 1 27 ARG 27 351 351 ARG ARG C . n C 1 28 LYS 28 352 352 LYS LYS C . n C 1 29 SER 29 353 353 SER SER C . n C 1 30 PRO 30 354 354 PRO PRO C . n C 1 31 THR 31 355 355 THR THR C . n C 1 32 ILE 32 356 356 ILE ILE C . n C 1 33 THR 33 357 357 THR THR C . n C 1 34 CYS 34 358 358 CYS CYS C . n C 1 35 LEU 35 359 359 LEU LEU C . n C 1 36 VAL 36 360 360 VAL VAL C . n C 1 37 VAL 37 361 361 VAL VAL C . n C 1 38 ASP 38 362 362 ASP ASP C . n C 1 39 LEU 39 363 363 LEU LEU C . n C 1 40 ALA 40 364 364 ALA ALA C . n C 1 41 PRO 41 365 365 PRO PRO C . n C 1 42 SER 42 366 366 SER SER C . n C 1 43 LYS 43 367 367 LYS LYS C . n C 1 44 GLY 44 368 368 GLY GLY C . n C 1 45 THR 45 369 369 THR THR C . n C 1 46 VAL 46 370 370 VAL VAL C . n C 1 47 GLN 47 371 371 GLN GLN C . n C 1 48 LEU 48 372 372 LEU LEU C . n C 1 49 THR 49 373 373 THR THR C . n C 1 50 TRP 50 374 374 TRP TRP C . n C 1 51 SER 51 375 375 SER SER C . n C 1 52 ARG 52 376 376 ARG ARG C . n C 1 53 ALA 53 377 377 ALA ALA C . n C 1 54 SER 54 378 378 SER SER C . n C 1 55 GLY 55 379 379 GLY GLY C . n C 1 56 LYS 56 380 380 LYS LYS C . n C 1 57 PRO 57 381 381 PRO PRO C . n C 1 58 VAL 58 382 382 VAL VAL C . n C 1 59 GLN 59 383 383 GLN GLN C . n C 1 60 HIS 60 384 384 HIS HIS C . n C 1 61 SER 61 385 385 SER SER C . n C 1 62 THR 62 386 386 THR THR C . n C 1 63 ARG 63 387 387 ARG ARG C . n C 1 64 LYS 64 388 388 LYS LYS C . n C 1 65 GLU 65 389 389 GLU GLU C . n C 1 66 GLU 66 390 390 GLU GLU C . n C 1 67 LYS 67 391 391 LYS LYS C . n C 1 68 GLN 68 392 392 GLN GLN C . n C 1 69 ARG 69 393 393 ARG ARG C . n C 1 70 ASN 70 394 394 ASN ASN C . n C 1 71 GLY 71 395 395 GLY GLY C . n C 1 72 THR 72 396 396 THR THR C . n C 1 73 LEU 73 397 397 LEU LEU C . n C 1 74 THR 74 398 398 THR THR C . n C 1 75 VAL 75 399 399 VAL VAL C . n C 1 76 THR 76 400 400 THR THR C . n C 1 77 SER 77 401 401 SER SER C . n C 1 78 THR 78 402 402 THR THR C . n C 1 79 LEU 79 403 403 LEU LEU C . n C 1 80 PRO 80 404 404 PRO PRO C . n C 1 81 VAL 81 405 405 VAL VAL C . n C 1 82 GLY 82 406 406 GLY GLY C . n C 1 83 THR 83 407 407 THR THR C . n C 1 84 ARG 84 408 408 ARG ARG C . n C 1 85 ASP 85 409 409 ASP ASP C . n C 1 86 TRP 86 410 410 TRP TRP C . n C 1 87 ILE 87 411 411 ILE ILE C . n C 1 88 GLU 88 412 412 GLU GLU C . n C 1 89 GLY 89 413 413 GLY GLY C . n C 1 90 GLU 90 414 414 GLU GLU C . n C 1 91 THR 91 415 415 THR THR C . n C 1 92 TYR 92 416 416 TYR TYR C . n C 1 93 GLN 93 417 417 GLN GLN C . n C 1 94 CYS 94 418 418 CYS CYS C . n C 1 95 ARG 95 419 419 ARG ARG C . n C 1 96 VAL 96 420 420 VAL VAL C . n C 1 97 THR 97 421 421 THR THR C . n C 1 98 HIS 98 422 422 HIS HIS C . n C 1 99 PRO 99 423 423 PRO PRO C . n C 1 100 HIS 100 424 424 HIS HIS C . n C 1 101 LEU 101 425 425 LEU LEU C . n C 1 102 PRO 102 426 426 PRO PRO C . n C 1 103 ARG 103 427 427 ARG ARG C . n C 1 104 ALA 104 428 428 ALA ALA C . n C 1 105 LEU 105 429 429 LEU LEU C . n C 1 106 MET 106 430 430 MET MET C . n C 1 107 ARG 107 431 431 ARG ARG C . n C 1 108 SER 108 432 432 SER SER C . n C 1 109 THR 109 433 433 THR THR C . n C 1 110 THR 110 434 434 THR THR C . n C 1 111 LYS 111 435 435 LYS LYS C . n C 1 112 THR 112 436 436 THR THR C . n C 1 113 SER 113 437 437 SER SER C . n C 1 114 GLY 114 438 438 GLY GLY C . n C 1 115 PRO 115 439 439 PRO PRO C . n C 1 116 ARG 116 440 440 ARG ARG C . n C 1 117 ALA 117 441 441 ALA ALA C . n C 1 118 ALA 118 442 442 ALA ALA C . n C 1 119 PRO 119 443 443 PRO PRO C . n C 1 120 GLU 120 444 444 GLU GLU C . n C 1 121 VAL 121 445 445 VAL VAL C . n C 1 122 TYR 122 446 446 TYR TYR C . n C 1 123 ALA 123 447 447 ALA ALA C . n C 1 124 PHE 124 448 448 PHE PHE C . n C 1 125 ALA 125 449 449 ALA ALA C . n C 1 126 THR 126 450 450 THR THR C . n C 1 127 PRO 127 451 451 PRO PRO C . n C 1 128 GLU 128 452 452 GLU GLU C . n C 1 129 TRP 129 453 453 TRP TRP C . n C 1 130 PRO 130 454 454 PRO PRO C . n C 1 131 GLY 131 455 455 GLY GLY C . n C 1 132 SER 132 456 456 SER SER C . n C 1 133 ARG 133 457 457 ARG ARG C . n C 1 134 ASP 134 458 458 ASP ASP C . n C 1 135 LYS 135 459 459 LYS LYS C . n C 1 136 ARG 136 460 460 ARG ARG C . n C 1 137 THR 137 461 461 THR THR C . n C 1 138 LEU 138 462 462 LEU LEU C . n C 1 139 ALA 139 463 463 ALA ALA C . n C 1 140 CYS 140 464 464 CYS CYS C . n C 1 141 LEU 141 465 465 LEU LEU C . n C 1 142 ILE 142 466 466 ILE ILE C . n C 1 143 GLN 143 467 467 GLN GLN C . n C 1 144 ASN 144 468 468 ASN ASN C . n C 1 145 PHE 145 469 469 PHE PHE C . n C 1 146 MET 146 470 470 MET MET C . n C 1 147 PRO 147 471 471 PRO PRO C . n C 1 148 GLU 148 472 472 GLU GLU C . n C 1 149 ASP 149 473 473 ASP ASP C . n C 1 150 ILE 150 474 474 ILE ILE C . n C 1 151 SER 151 475 475 SER SER C . n C 1 152 VAL 152 476 476 VAL VAL C . n C 1 153 GLN 153 477 477 GLN GLN C . n C 1 154 TRP 154 478 478 TRP TRP C . n C 1 155 LEU 155 479 479 LEU LEU C . n C 1 156 HIS 156 480 480 HIS HIS C . n C 1 157 ASN 157 481 481 ASN ASN C . n C 1 158 GLU 158 482 482 GLU GLU C . n C 1 159 VAL 159 483 483 VAL VAL C . n C 1 160 GLN 160 484 484 GLN GLN C . n C 1 161 LEU 161 485 485 LEU LEU C . n C 1 162 PRO 162 486 486 PRO PRO C . n C 1 163 ASP 163 487 487 ASP ASP C . n C 1 164 ALA 164 488 488 ALA ALA C . n C 1 165 ARG 165 489 489 ARG ARG C . n C 1 166 HIS 166 490 490 HIS HIS C . n C 1 167 SER 167 491 491 SER SER C . n C 1 168 THR 168 492 492 THR THR C . n C 1 169 THR 169 493 493 THR THR C . n C 1 170 GLN 170 494 494 GLN GLN C . n C 1 171 PRO 171 495 495 PRO PRO C . n C 1 172 ARG 172 496 496 ARG ARG C . n C 1 173 LYS 173 497 497 LYS LYS C . n C 1 174 THR 174 498 498 THR THR C . n C 1 175 LYS 175 499 499 LYS LYS C . n C 1 176 GLY 176 500 500 GLY GLY C . n C 1 177 SER 177 501 501 SER SER C . n C 1 178 GLY 178 502 502 GLY GLY C . n C 1 179 PHE 179 503 503 PHE PHE C . n C 1 180 PHE 180 504 504 PHE PHE C . n C 1 181 VAL 181 505 505 VAL VAL C . n C 1 182 PHE 182 506 506 PHE PHE C . n C 1 183 SER 183 507 507 SER SER C . n C 1 184 ARG 184 508 508 ARG ARG C . n C 1 185 LEU 185 509 509 LEU LEU C . n C 1 186 GLU 186 510 510 GLU GLU C . n C 1 187 VAL 187 511 511 VAL VAL C . n C 1 188 THR 188 512 512 THR THR C . n C 1 189 ARG 189 513 513 ARG ARG C . n C 1 190 ALA 190 514 514 ALA ALA C . n C 1 191 GLU 191 515 515 GLU GLU C . n C 1 192 TRP 192 516 516 TRP TRP C . n C 1 193 GLU 193 517 517 GLU GLU C . n C 1 194 GLN 194 518 518 GLN GLN C . n C 1 195 LYS 195 519 519 LYS LYS C . n C 1 196 ASP 196 520 520 ASP ASP C . n C 1 197 GLU 197 521 521 GLU GLU C . n C 1 198 PHE 198 522 522 PHE PHE C . n C 1 199 ILE 199 523 523 ILE ILE C . n C 1 200 CYS 200 524 524 CYS CYS C . n C 1 201 ARG 201 525 525 ARG ARG C . n C 1 202 ALA 202 526 526 ALA ALA C . n C 1 203 VAL 203 527 527 VAL VAL C . n C 1 204 HIS 204 528 528 HIS HIS C . n C 1 205 GLU 205 529 529 GLU GLU C . n C 1 206 ALA 206 530 530 ALA ALA C . n C 1 207 ALA 207 531 531 ALA ALA C . n C 1 208 SER 208 532 532 SER SER C . n C 1 209 PRO 209 533 533 PRO PRO C . n C 1 210 SER 210 534 534 SER SER C . n C 1 211 GLN 211 535 535 GLN GLN C . n C 1 212 THR 212 536 536 THR THR C . n C 1 213 VAL 213 537 537 VAL VAL C . n C 1 214 GLN 214 538 538 GLN GLN C . n C 1 215 ARG 215 539 539 ARG ARG C . n C 1 216 ALA 216 540 540 ALA ALA C . n C 1 217 VAL 217 541 541 VAL VAL C . n C 1 218 SER 218 542 542 SER SER C . n C 1 219 VAL 219 543 543 VAL VAL C . n C 1 220 ASN 220 544 544 ASN ASN C . n C 1 221 PRO 221 545 ? ? ? C . n C 1 222 GLY 222 546 ? ? ? C . n C 1 223 LYS 223 547 ? ? ? C . n D 1 1 ALA 1 325 ? ? ? D . n D 1 2 ASP 2 326 ? ? ? D . n D 1 3 PRO 3 327 ? ? ? D . n D 1 4 CYS 4 328 ? ? ? D . n D 1 5 ALA 5 329 ? ? ? D . n D 1 6 ASP 6 330 ? ? ? D . n D 1 7 SER 7 331 ? ? ? D . n D 1 8 ASN 8 332 ? ? ? D . n D 1 9 PRO 9 333 ? ? ? D . n D 1 10 ARG 10 334 ? ? ? D . n D 1 11 GLY 11 335 ? ? ? D . n D 1 12 VAL 12 336 336 VAL VAL D . n D 1 13 SER 13 337 337 SER SER D . n D 1 14 ALA 14 338 338 ALA ALA D . n D 1 15 TYR 15 339 339 TYR TYR D . n D 1 16 LEU 16 340 340 LEU LEU D . n D 1 17 SER 17 341 341 SER SER D . n D 1 18 ARG 18 342 342 ARG ARG D . n D 1 19 PRO 19 343 343 PRO PRO D . n D 1 20 SER 20 344 344 SER SER D . n D 1 21 PRO 21 345 345 PRO PRO D . n D 1 22 PHE 22 346 346 PHE PHE D . n D 1 23 ASP 23 347 347 ASP ASP D . n D 1 24 LEU 24 348 348 LEU LEU D . n D 1 25 PHE 25 349 349 PHE PHE D . n D 1 26 ILE 26 350 350 ILE ILE D . n D 1 27 ARG 27 351 351 ARG ARG D . n D 1 28 LYS 28 352 352 LYS LYS D . n D 1 29 SER 29 353 353 SER SER D . n D 1 30 PRO 30 354 354 PRO PRO D . n D 1 31 THR 31 355 355 THR THR D . n D 1 32 ILE 32 356 356 ILE ILE D . n D 1 33 THR 33 357 357 THR THR D . n D 1 34 CYS 34 358 358 CYS CYS D . n D 1 35 LEU 35 359 359 LEU LEU D . n D 1 36 VAL 36 360 360 VAL VAL D . n D 1 37 VAL 37 361 361 VAL VAL D . n D 1 38 ASP 38 362 362 ASP ASP D . n D 1 39 LEU 39 363 363 LEU LEU D . n D 1 40 ALA 40 364 364 ALA ALA D . n D 1 41 PRO 41 365 365 PRO PRO D . n D 1 42 SER 42 366 366 SER SER D . n D 1 43 LYS 43 367 367 LYS LYS D . n D 1 44 GLY 44 368 368 GLY GLY D . n D 1 45 THR 45 369 369 THR THR D . n D 1 46 VAL 46 370 370 VAL VAL D . n D 1 47 GLN 47 371 371 GLN GLN D . n D 1 48 LEU 48 372 372 LEU LEU D . n D 1 49 THR 49 373 373 THR THR D . n D 1 50 TRP 50 374 374 TRP TRP D . n D 1 51 SER 51 375 375 SER SER D . n D 1 52 ARG 52 376 376 ARG ARG D . n D 1 53 ALA 53 377 377 ALA ALA D . n D 1 54 SER 54 378 378 SER SER D . n D 1 55 GLY 55 379 379 GLY GLY D . n D 1 56 LYS 56 380 380 LYS LYS D . n D 1 57 PRO 57 381 381 PRO PRO D . n D 1 58 VAL 58 382 382 VAL VAL D . n D 1 59 GLN 59 383 383 GLN GLN D . n D 1 60 HIS 60 384 384 HIS HIS D . n D 1 61 SER 61 385 385 SER SER D . n D 1 62 THR 62 386 386 THR THR D . n D 1 63 ARG 63 387 387 ARG ARG D . n D 1 64 LYS 64 388 388 LYS LYS D . n D 1 65 GLU 65 389 389 GLU GLU D . n D 1 66 GLU 66 390 390 GLU GLU D . n D 1 67 LYS 67 391 391 LYS LYS D . n D 1 68 GLN 68 392 392 GLN GLN D . n D 1 69 ARG 69 393 393 ARG ARG D . n D 1 70 ASN 70 394 394 ASN ASN D . n D 1 71 GLY 71 395 395 GLY GLY D . n D 1 72 THR 72 396 396 THR THR D . n D 1 73 LEU 73 397 397 LEU LEU D . n D 1 74 THR 74 398 398 THR THR D . n D 1 75 VAL 75 399 399 VAL VAL D . n D 1 76 THR 76 400 400 THR THR D . n D 1 77 SER 77 401 401 SER SER D . n D 1 78 THR 78 402 402 THR THR D . n D 1 79 LEU 79 403 403 LEU LEU D . n D 1 80 PRO 80 404 404 PRO PRO D . n D 1 81 VAL 81 405 405 VAL VAL D . n D 1 82 GLY 82 406 406 GLY GLY D . n D 1 83 THR 83 407 407 THR THR D . n D 1 84 ARG 84 408 408 ARG ARG D . n D 1 85 ASP 85 409 409 ASP ASP D . n D 1 86 TRP 86 410 410 TRP TRP D . n D 1 87 ILE 87 411 411 ILE ILE D . n D 1 88 GLU 88 412 412 GLU GLU D . n D 1 89 GLY 89 413 413 GLY GLY D . n D 1 90 GLU 90 414 414 GLU GLU D . n D 1 91 THR 91 415 415 THR THR D . n D 1 92 TYR 92 416 416 TYR TYR D . n D 1 93 GLN 93 417 417 GLN GLN D . n D 1 94 CYS 94 418 418 CYS CYS D . n D 1 95 ARG 95 419 419 ARG ARG D . n D 1 96 VAL 96 420 420 VAL VAL D . n D 1 97 THR 97 421 421 THR THR D . n D 1 98 HIS 98 422 422 HIS HIS D . n D 1 99 PRO 99 423 423 PRO PRO D . n D 1 100 HIS 100 424 424 HIS HIS D . n D 1 101 LEU 101 425 425 LEU LEU D . n D 1 102 PRO 102 426 426 PRO PRO D . n D 1 103 ARG 103 427 427 ARG ARG D . n D 1 104 ALA 104 428 428 ALA ALA D . n D 1 105 LEU 105 429 429 LEU LEU D . n D 1 106 MET 106 430 430 MET MET D . n D 1 107 ARG 107 431 431 ARG ARG D . n D 1 108 SER 108 432 432 SER SER D . n D 1 109 THR 109 433 433 THR THR D . n D 1 110 THR 110 434 434 THR THR D . n D 1 111 LYS 111 435 435 LYS LYS D . n D 1 112 THR 112 436 436 THR THR D . n D 1 113 SER 113 437 437 SER SER D . n D 1 114 GLY 114 438 438 GLY GLY D . n D 1 115 PRO 115 439 439 PRO PRO D . n D 1 116 ARG 116 440 440 ARG ARG D . n D 1 117 ALA 117 441 441 ALA ALA D . n D 1 118 ALA 118 442 442 ALA ALA D . n D 1 119 PRO 119 443 443 PRO PRO D . n D 1 120 GLU 120 444 444 GLU GLU D . n D 1 121 VAL 121 445 445 VAL VAL D . n D 1 122 TYR 122 446 446 TYR TYR D . n D 1 123 ALA 123 447 447 ALA ALA D . n D 1 124 PHE 124 448 448 PHE PHE D . n D 1 125 ALA 125 449 449 ALA ALA D . n D 1 126 THR 126 450 450 THR THR D . n D 1 127 PRO 127 451 451 PRO PRO D . n D 1 128 GLU 128 452 452 GLU GLU D . n D 1 129 TRP 129 453 453 TRP TRP D . n D 1 130 PRO 130 454 454 PRO PRO D . n D 1 131 GLY 131 455 455 GLY GLY D . n D 1 132 SER 132 456 456 SER SER D . n D 1 133 ARG 133 457 457 ARG ARG D . n D 1 134 ASP 134 458 458 ASP ASP D . n D 1 135 LYS 135 459 459 LYS LYS D . n D 1 136 ARG 136 460 460 ARG ARG D . n D 1 137 THR 137 461 461 THR THR D . n D 1 138 LEU 138 462 462 LEU LEU D . n D 1 139 ALA 139 463 463 ALA ALA D . n D 1 140 CYS 140 464 464 CYS CYS D . n D 1 141 LEU 141 465 465 LEU LEU D . n D 1 142 ILE 142 466 466 ILE ILE D . n D 1 143 GLN 143 467 467 GLN GLN D . n D 1 144 ASN 144 468 468 ASN ASN D . n D 1 145 PHE 145 469 469 PHE PHE D . n D 1 146 MET 146 470 470 MET MET D . n D 1 147 PRO 147 471 471 PRO PRO D . n D 1 148 GLU 148 472 472 GLU GLU D . n D 1 149 ASP 149 473 473 ASP ASP D . n D 1 150 ILE 150 474 474 ILE ILE D . n D 1 151 SER 151 475 475 SER SER D . n D 1 152 VAL 152 476 476 VAL VAL D . n D 1 153 GLN 153 477 477 GLN GLN D . n D 1 154 TRP 154 478 478 TRP TRP D . n D 1 155 LEU 155 479 479 LEU LEU D . n D 1 156 HIS 156 480 480 HIS HIS D . n D 1 157 ASN 157 481 481 ASN ASN D . n D 1 158 GLU 158 482 482 GLU GLU D . n D 1 159 VAL 159 483 483 VAL VAL D . n D 1 160 GLN 160 484 484 GLN GLN D . n D 1 161 LEU 161 485 485 LEU LEU D . n D 1 162 PRO 162 486 486 PRO PRO D . n D 1 163 ASP 163 487 487 ASP ASP D . n D 1 164 ALA 164 488 488 ALA ALA D . n D 1 165 ARG 165 489 489 ARG ARG D . n D 1 166 HIS 166 490 490 HIS HIS D . n D 1 167 SER 167 491 491 SER SER D . n D 1 168 THR 168 492 492 THR THR D . n D 1 169 THR 169 493 493 THR THR D . n D 1 170 GLN 170 494 494 GLN GLN D . n D 1 171 PRO 171 495 495 PRO PRO D . n D 1 172 ARG 172 496 496 ARG ARG D . n D 1 173 LYS 173 497 497 LYS LYS D . n D 1 174 THR 174 498 498 THR THR D . n D 1 175 LYS 175 499 499 LYS LYS D . n D 1 176 GLY 176 500 500 GLY GLY D . n D 1 177 SER 177 501 501 SER SER D . n D 1 178 GLY 178 502 502 GLY GLY D . n D 1 179 PHE 179 503 503 PHE PHE D . n D 1 180 PHE 180 504 504 PHE PHE D . n D 1 181 VAL 181 505 505 VAL VAL D . n D 1 182 PHE 182 506 506 PHE PHE D . n D 1 183 SER 183 507 507 SER SER D . n D 1 184 ARG 184 508 508 ARG ARG D . n D 1 185 LEU 185 509 509 LEU LEU D . n D 1 186 GLU 186 510 510 GLU GLU D . n D 1 187 VAL 187 511 511 VAL VAL D . n D 1 188 THR 188 512 512 THR THR D . n D 1 189 ARG 189 513 513 ARG ARG D . n D 1 190 ALA 190 514 514 ALA ALA D . n D 1 191 GLU 191 515 515 GLU GLU D . n D 1 192 TRP 192 516 516 TRP TRP D . n D 1 193 GLU 193 517 517 GLU GLU D . n D 1 194 GLN 194 518 518 GLN GLN D . n D 1 195 LYS 195 519 519 LYS LYS D . n D 1 196 ASP 196 520 520 ASP ASP D . n D 1 197 GLU 197 521 521 GLU GLU D . n D 1 198 PHE 198 522 522 PHE PHE D . n D 1 199 ILE 199 523 523 ILE ILE D . n D 1 200 CYS 200 524 524 CYS CYS D . n D 1 201 ARG 201 525 525 ARG ARG D . n D 1 202 ALA 202 526 526 ALA ALA D . n D 1 203 VAL 203 527 527 VAL VAL D . n D 1 204 HIS 204 528 528 HIS HIS D . n D 1 205 GLU 205 529 529 GLU GLU D . n D 1 206 ALA 206 530 530 ALA ALA D . n D 1 207 ALA 207 531 531 ALA ALA D . n D 1 208 SER 208 532 532 SER SER D . n D 1 209 PRO 209 533 533 PRO PRO D . n D 1 210 SER 210 534 534 SER SER D . n D 1 211 GLN 211 535 535 GLN GLN D . n D 1 212 THR 212 536 536 THR THR D . n D 1 213 VAL 213 537 537 VAL VAL D . n D 1 214 GLN 214 538 538 GLN GLN D . n D 1 215 ARG 215 539 539 ARG ARG D . n D 1 216 ALA 216 540 540 ALA ALA D . n D 1 217 VAL 217 541 541 VAL VAL D . n D 1 218 SER 218 542 542 SER SER D . n D 1 219 VAL 219 543 543 VAL VAL D . n D 1 220 ASN 220 544 544 ASN ASN D . n D 1 221 PRO 221 545 ? ? ? D . n D 1 222 GLY 222 546 ? ? ? D . n D 1 223 LYS 223 547 ? ? ? D . n # loop_ _pdbx_nonpoly_scheme.asym_id _pdbx_nonpoly_scheme.entity_id _pdbx_nonpoly_scheme.mon_id _pdbx_nonpoly_scheme.ndb_seq_num _pdbx_nonpoly_scheme.pdb_seq_num _pdbx_nonpoly_scheme.auth_seq_num _pdbx_nonpoly_scheme.pdb_mon_id _pdbx_nonpoly_scheme.auth_mon_id _pdbx_nonpoly_scheme.pdb_strand_id _pdbx_nonpoly_scheme.pdb_ins_code E 2 NAG 1 1 1 NAG NAG B . F 2 NAG 2 2 2 NAG NAG B . G 3 BMA 3 3 3 BMA BMA B . H 4 MAN 4 4 4 MAN MAN B . I 4 MAN 5 5 5 MAN MAN B . J 2 NAG 1 1 1 NAG NAG C . K 2 NAG 2 2 2 NAG NAG C . L 3 BMA 3 3 3 BMA BMA C . M 4 MAN 4 4 4 MAN MAN C . N 4 MAN 5 5 5 MAN MAN C . O 5 NH4 1 548 1 NH4 NH4 C . P 2 NAG 1 1 1 NAG NAG D . Q 2 NAG 2 2 2 NAG NAG D . R 3 BMA 3 3 3 BMA BMA D . S 4 MAN 4 4 4 MAN MAN D . T 4 MAN 5 5 5 MAN MAN D . U 6 HOH 1 5 5 HOH HOH A . U 6 HOH 2 6 6 HOH HOH A . U 6 HOH 3 8 8 HOH HOH A . U 6 HOH 4 9 9 HOH HOH A . U 6 HOH 5 32 32 HOH HOH A . U 6 HOH 6 37 37 HOH HOH A . U 6 HOH 7 50 50 HOH HOH A . U 6 HOH 8 53 53 HOH HOH A . U 6 HOH 9 55 55 HOH HOH A . U 6 HOH 10 59 59 HOH HOH A . U 6 HOH 11 60 60 HOH HOH A . U 6 HOH 12 68 68 HOH HOH A . U 6 HOH 13 80 80 HOH HOH A . U 6 HOH 14 89 89 HOH HOH A . U 6 HOH 15 90 90 HOH HOH A . U 6 HOH 16 95 95 HOH HOH A . U 6 HOH 17 96 96 HOH HOH A . U 6 HOH 18 98 98 HOH HOH A . U 6 HOH 19 99 99 HOH HOH A . U 6 HOH 20 126 126 HOH HOH A . U 6 HOH 21 137 137 HOH HOH A . U 6 HOH 22 139 139 HOH HOH A . U 6 HOH 23 144 144 HOH HOH A . U 6 HOH 24 168 168 HOH HOH A . U 6 HOH 25 176 176 HOH HOH A . U 6 HOH 26 181 181 HOH HOH A . U 6 HOH 27 188 188 HOH HOH A . U 6 HOH 28 195 195 HOH HOH A . U 6 HOH 29 209 209 HOH HOH A . U 6 HOH 30 214 214 HOH HOH A . U 6 HOH 31 229 229 HOH HOH A . V 6 HOH 1 10 10 HOH HOH B . V 6 HOH 2 14 14 HOH HOH B . V 6 HOH 3 19 19 HOH HOH B . V 6 HOH 4 20 20 HOH HOH B . V 6 HOH 5 22 22 HOH HOH B . V 6 HOH 6 29 29 HOH HOH B . V 6 HOH 7 30 30 HOH HOH B . V 6 HOH 8 36 36 HOH HOH B . V 6 HOH 9 39 39 HOH HOH B . V 6 HOH 10 41 41 HOH HOH B . V 6 HOH 11 51 51 HOH HOH B . V 6 HOH 12 54 54 HOH HOH B . V 6 HOH 13 57 57 HOH HOH B . V 6 HOH 14 66 66 HOH HOH B . V 6 HOH 15 72 72 HOH HOH B . V 6 HOH 16 76 76 HOH HOH B . V 6 HOH 17 83 83 HOH HOH B . V 6 HOH 18 85 85 HOH HOH B . V 6 HOH 19 100 100 HOH HOH B . V 6 HOH 20 104 104 HOH HOH B . V 6 HOH 21 106 106 HOH HOH B . V 6 HOH 22 111 111 HOH HOH B . V 6 HOH 23 116 116 HOH HOH B . V 6 HOH 24 117 117 HOH HOH B . V 6 HOH 25 127 127 HOH HOH B . V 6 HOH 26 143 143 HOH HOH B . V 6 HOH 27 146 146 HOH HOH B . V 6 HOH 28 147 147 HOH HOH B . V 6 HOH 29 149 149 HOH HOH B . V 6 HOH 30 152 152 HOH HOH B . V 6 HOH 31 159 159 HOH HOH B . V 6 HOH 32 173 173 HOH HOH B . V 6 HOH 33 184 184 HOH HOH B . V 6 HOH 34 191 191 HOH HOH B . V 6 HOH 35 197 197 HOH HOH B . V 6 HOH 36 200 200 HOH HOH B . V 6 HOH 37 220 220 HOH HOH B . V 6 HOH 38 548 4 HOH HOH B . W 6 HOH 1 11 11 HOH HOH C . W 6 HOH 2 12 12 HOH HOH C . W 6 HOH 3 13 13 HOH HOH C . W 6 HOH 4 17 17 HOH HOH C . W 6 HOH 5 21 21 HOH HOH C . W 6 HOH 6 25 25 HOH HOH C . W 6 HOH 7 26 26 HOH HOH C . W 6 HOH 8 27 27 HOH HOH C . W 6 HOH 9 28 28 HOH HOH C . W 6 HOH 10 31 31 HOH HOH C . W 6 HOH 11 35 35 HOH HOH C . W 6 HOH 12 43 43 HOH HOH C . W 6 HOH 13 44 44 HOH HOH C . W 6 HOH 14 47 47 HOH HOH C . W 6 HOH 15 49 49 HOH HOH C . W 6 HOH 16 52 52 HOH HOH C . W 6 HOH 17 58 58 HOH HOH C . W 6 HOH 18 63 63 HOH HOH C . W 6 HOH 19 67 67 HOH HOH C . W 6 HOH 20 73 73 HOH HOH C . W 6 HOH 21 74 74 HOH HOH C . W 6 HOH 22 75 75 HOH HOH C . W 6 HOH 23 77 77 HOH HOH C . W 6 HOH 24 78 78 HOH HOH C . W 6 HOH 25 79 79 HOH HOH C . W 6 HOH 26 82 82 HOH HOH C . W 6 HOH 27 84 84 HOH HOH C . W 6 HOH 28 94 94 HOH HOH C . W 6 HOH 29 107 107 HOH HOH C . W 6 HOH 30 108 108 HOH HOH C . W 6 HOH 31 109 109 HOH HOH C . W 6 HOH 32 113 113 HOH HOH C . W 6 HOH 33 120 120 HOH HOH C . W 6 HOH 34 125 125 HOH HOH C . W 6 HOH 35 134 134 HOH HOH C . W 6 HOH 36 145 145 HOH HOH C . W 6 HOH 37 148 148 HOH HOH C . W 6 HOH 38 155 155 HOH HOH C . W 6 HOH 39 171 171 HOH HOH C . W 6 HOH 40 192 192 HOH HOH C . W 6 HOH 41 203 203 HOH HOH C . W 6 HOH 42 210 210 HOH HOH C . W 6 HOH 43 211 211 HOH HOH C . W 6 HOH 44 218 218 HOH HOH C . W 6 HOH 45 232 232 HOH HOH C . W 6 HOH 46 235 235 HOH HOH C . W 6 HOH 47 549 2 HOH HOH C . X 6 HOH 1 7 7 HOH HOH D . X 6 HOH 2 16 16 HOH HOH D . X 6 HOH 3 18 18 HOH HOH D . X 6 HOH 4 45 45 HOH HOH D . X 6 HOH 5 46 46 HOH HOH D . X 6 HOH 6 48 48 HOH HOH D . X 6 HOH 7 69 69 HOH HOH D . X 6 HOH 8 81 81 HOH HOH D . X 6 HOH 9 87 87 HOH HOH D . X 6 HOH 10 91 91 HOH HOH D . X 6 HOH 11 93 93 HOH HOH D . X 6 HOH 12 97 97 HOH HOH D . X 6 HOH 13 103 103 HOH HOH D . X 6 HOH 14 110 110 HOH HOH D . X 6 HOH 15 114 114 HOH HOH D . X 6 HOH 16 118 118 HOH HOH D . X 6 HOH 17 124 124 HOH HOH D . X 6 HOH 18 131 131 HOH HOH D . X 6 HOH 19 133 133 HOH HOH D . X 6 HOH 20 151 151 HOH HOH D . X 6 HOH 21 157 157 HOH HOH D . X 6 HOH 22 162 162 HOH HOH D . X 6 HOH 23 174 174 HOH HOH D . X 6 HOH 24 178 178 HOH HOH D . X 6 HOH 25 179 179 HOH HOH D . X 6 HOH 26 182 182 HOH HOH D . X 6 HOH 27 202 202 HOH HOH D . X 6 HOH 28 212 212 HOH HOH D . X 6 HOH 29 231 231 HOH HOH D . X 6 HOH 30 548 3 HOH HOH D . # loop_ _pdbx_struct_mod_residue.id _pdbx_struct_mod_residue.label_asym_id _pdbx_struct_mod_residue.label_comp_id _pdbx_struct_mod_residue.label_seq_id _pdbx_struct_mod_residue.auth_asym_id _pdbx_struct_mod_residue.auth_comp_id _pdbx_struct_mod_residue.auth_seq_id _pdbx_struct_mod_residue.PDB_ins_code _pdbx_struct_mod_residue.parent_comp_id _pdbx_struct_mod_residue.details 1 B ASN 70 B ASN 394 ? ASN 'GLYCOSYLATION SITE' 2 C ASN 70 C ASN 394 ? ASN 'GLYCOSYLATION SITE' 3 D ASN 70 D ASN 394 ? ASN 'GLYCOSYLATION SITE' # loop_ _pdbx_struct_assembly.id _pdbx_struct_assembly.details _pdbx_struct_assembly.method_details _pdbx_struct_assembly.oligomeric_details _pdbx_struct_assembly.oligomeric_count 1 author_and_software_defined_assembly PISA dimeric 2 2 author_and_software_defined_assembly PISA dimeric 2 # loop_ _pdbx_struct_assembly_gen.assembly_id _pdbx_struct_assembly_gen.oper_expression _pdbx_struct_assembly_gen.asym_id_list 1 1 A,B,E,F,G,H,I,U,V 2 1 C,D,J,K,L,M,N,O,P,Q,R,S,T,W,X # loop_ _pdbx_struct_assembly_prop.biol_id _pdbx_struct_assembly_prop.type _pdbx_struct_assembly_prop.value _pdbx_struct_assembly_prop.details 1 'ABSA (A^2)' 2590 ? 1 MORE -13.1 ? 1 'SSA (A^2)' 22160 ? 2 'ABSA (A^2)' 2520 ? 2 MORE -12.9 ? 2 'SSA (A^2)' 22180 ? # _pdbx_struct_oper_list.id 1 _pdbx_struct_oper_list.type 'identity operation' _pdbx_struct_oper_list.name 1_555 _pdbx_struct_oper_list.symmetry_operation x,y,z _pdbx_struct_oper_list.matrix[1][1] 1.0000000000 _pdbx_struct_oper_list.matrix[1][2] 0.0000000000 _pdbx_struct_oper_list.matrix[1][3] 0.0000000000 _pdbx_struct_oper_list.vector[1] 0.0000000000 _pdbx_struct_oper_list.matrix[2][1] 0.0000000000 _pdbx_struct_oper_list.matrix[2][2] 1.0000000000 _pdbx_struct_oper_list.matrix[2][3] 0.0000000000 _pdbx_struct_oper_list.vector[2] 0.0000000000 _pdbx_struct_oper_list.matrix[3][1] 0.0000000000 _pdbx_struct_oper_list.matrix[3][2] 0.0000000000 _pdbx_struct_oper_list.matrix[3][3] 1.0000000000 _pdbx_struct_oper_list.vector[3] 0.0000000000 # loop_ _pdbx_audit_revision_history.ordinal _pdbx_audit_revision_history.data_content_type _pdbx_audit_revision_history.major_revision _pdbx_audit_revision_history.minor_revision _pdbx_audit_revision_history.revision_date 1 'Structure model' 1 0 2009-09-08 2 'Structure model' 1 1 2011-07-13 3 'Structure model' 1 2 2017-11-01 # _pdbx_audit_revision_details.ordinal 1 _pdbx_audit_revision_details.revision_ordinal 1 _pdbx_audit_revision_details.data_content_type 'Structure model' _pdbx_audit_revision_details.provider repository _pdbx_audit_revision_details.type 'Initial release' _pdbx_audit_revision_details.description ? # loop_ _pdbx_audit_revision_group.ordinal _pdbx_audit_revision_group.revision_ordinal _pdbx_audit_revision_group.data_content_type _pdbx_audit_revision_group.group 1 2 'Structure model' Advisory 2 2 'Structure model' 'Refinement description' 3 2 'Structure model' 'Version format compliance' 4 3 'Structure model' 'Refinement description' # _pdbx_audit_revision_category.ordinal 1 _pdbx_audit_revision_category.revision_ordinal 3 _pdbx_audit_revision_category.data_content_type 'Structure model' _pdbx_audit_revision_category.category software # loop_ _pdbx_refine_tls.pdbx_refine_id _pdbx_refine_tls.id _pdbx_refine_tls.details _pdbx_refine_tls.method _pdbx_refine_tls.origin_x _pdbx_refine_tls.origin_y _pdbx_refine_tls.origin_z _pdbx_refine_tls.T[1][1] _pdbx_refine_tls.T[2][2] _pdbx_refine_tls.T[3][3] _pdbx_refine_tls.T[1][2] _pdbx_refine_tls.T[1][3] _pdbx_refine_tls.T[2][3] _pdbx_refine_tls.L[1][1] _pdbx_refine_tls.L[2][2] _pdbx_refine_tls.L[3][3] _pdbx_refine_tls.L[1][2] _pdbx_refine_tls.L[1][3] _pdbx_refine_tls.L[2][3] _pdbx_refine_tls.S[1][1] _pdbx_refine_tls.S[2][2] _pdbx_refine_tls.S[3][3] _pdbx_refine_tls.S[1][2] _pdbx_refine_tls.S[1][3] _pdbx_refine_tls.S[2][3] _pdbx_refine_tls.S[2][1] _pdbx_refine_tls.S[3][1] _pdbx_refine_tls.S[3][2] 'X-RAY DIFFRACTION' 1 ? refined 96.9456 -27.8232 37.2487 -0.0405 0.0159 -0.1348 0.0374 0.0935 -0.0404 3.0575 2.8460 2.6998 -0.7251 -0.2046 0.6904 -0.1752 0.1741 0.0011 -0.0624 -0.2688 0.1054 0.1915 0.4011 0.1980 'X-RAY DIFFRACTION' 2 ? refined 100.3596 -9.0196 44.5183 0.0387 0.1000 0.0461 0.0123 0.0094 -0.0405 5.4757 13.9244 1.1723 8.7319 2.5336 4.0403 -0.1935 0.3065 -0.1129 0.0542 0.3992 0.4637 0.0927 0.1902 0.0720 'X-RAY DIFFRACTION' 3 ? refined 119.1932 -11.9530 28.9467 -0.0811 -0.1157 -0.0342 0.0084 -0.0146 0.0156 4.4341 1.9615 3.7722 -0.5680 -1.8602 0.5778 -0.0133 -0.0019 0.0151 0.0719 0.1589 0.0467 0.0967 -0.0552 -0.0272 'X-RAY DIFFRACTION' 4 ? refined 124.6938 -37.5912 56.0347 -0.0438 -0.0717 -0.0199 -0.0211 0.0147 -0.0428 2.6196 3.5508 2.9987 -0.7004 0.1044 0.0418 -0.0875 -0.0976 0.1851 -0.0439 -0.1615 0.4252 0.2282 0.0040 -0.3718 'X-RAY DIFFRACTION' 5 ? refined 133.8125 -37.9592 37.7339 0.0442 0.0062 -0.0075 0.0028 -0.0088 -0.0096 1.7615 2.3016 15.0623 1.4751 -4.8330 -5.4334 0.0246 -0.1971 0.1725 -0.0439 0.0291 -0.1612 -0.1267 0.0442 -0.0526 'X-RAY DIFFRACTION' 6 ? refined 131.6502 -13.8489 40.4927 -0.0446 -0.0095 -0.0563 0.0193 -0.0231 0.0073 1.4176 2.9904 1.9439 -0.8035 0.3924 0.2762 -0.0217 0.0251 -0.0034 -0.0715 0.1227 -0.1378 -0.0434 -0.1572 -0.0301 'X-RAY DIFFRACTION' 7 ? refined 69.4723 -31.7178 1.5571 -0.0352 -0.0406 -0.0788 0.0375 0.1293 -0.0013 3.5066 2.7701 4.1099 0.2401 0.8086 1.4518 -0.0879 0.0767 0.0112 -0.0498 -0.3249 0.0386 0.5032 0.5953 0.0764 'X-RAY DIFFRACTION' 8 ? refined 75.2368 -13.2074 7.6054 -0.0273 0.0071 0.0078 0.0274 0.0083 -0.0068 8.5971 12.4546 1.1112 10.2035 0.1833 0.8353 -0.1806 0.0682 0.1124 -0.2979 0.4920 0.3529 0.1406 -0.0949 -0.1113 'X-RAY DIFFRACTION' 9 ? refined 92.0721 -18.0068 -9.6999 -0.0479 -0.0701 -0.0438 0.0079 -0.0055 -0.0193 2.2042 1.4926 3.3348 -0.6383 -0.6023 0.5143 0.0490 -0.0087 -0.0403 -0.0327 -0.0044 -0.0037 0.0331 0.1422 0.0699 'X-RAY DIFFRACTION' 10 ? refined 98.1810 -41.7957 17.2143 -0.0125 -0.0910 -0.0398 0.0357 -0.0414 -0.1012 2.2319 3.8634 2.6445 -0.0621 -0.0466 0.4082 -0.0668 -0.2324 0.2991 -0.1820 -0.0275 0.5213 -0.0377 -0.0325 -0.2659 'X-RAY DIFFRACTION' 11 ? refined 107.4463 -44.1270 -0.8667 0.1310 0.0181 0.0389 0.0210 0.0125 0.0153 5.5035 1.0005 13.8168 2.3465 -8.7201 -3.7180 -0.0058 -0.0430 0.0488 -0.1523 0.3085 0.0112 -0.1001 0.1096 -0.2788 'X-RAY DIFFRACTION' 12 ? refined 105.2765 -19.6607 1.1523 -0.0653 -0.0631 -0.1255 0.0207 0.0049 0.0110 1.7380 4.0932 2.3782 -0.6611 0.5395 0.7328 -0.0197 -0.0514 0.0711 -0.0220 0.0718 0.0687 -0.0855 -0.0542 0.1134 # loop_ _pdbx_refine_tls_group.pdbx_refine_id _pdbx_refine_tls_group.id _pdbx_refine_tls_group.refine_tls_id _pdbx_refine_tls_group.beg_auth_asym_id _pdbx_refine_tls_group.beg_auth_seq_id _pdbx_refine_tls_group.end_auth_asym_id _pdbx_refine_tls_group.end_auth_seq_id _pdbx_refine_tls_group.selection_details _pdbx_refine_tls_group.beg_label_asym_id _pdbx_refine_tls_group.beg_label_seq_id _pdbx_refine_tls_group.end_label_asym_id _pdbx_refine_tls_group.end_label_seq_id _pdbx_refine_tls_group.selection 'X-RAY DIFFRACTION' 1 1 A 336 A 433 ? . . . . ? 'X-RAY DIFFRACTION' 2 2 A 434 A 440 ? . . . . ? 'X-RAY DIFFRACTION' 3 3 A 441 A 544 ? . . . . ? 'X-RAY DIFFRACTION' 4 4 B 1 B 5 ? . . . . ? 'X-RAY DIFFRACTION' 5 4 B 336 B 433 ? . . . . ? 'X-RAY DIFFRACTION' 6 5 B 434 B 440 ? . . . . ? 'X-RAY DIFFRACTION' 7 6 B 441 B 544 ? . . . . ? 'X-RAY DIFFRACTION' 8 7 C 1 C 5 ? . . . . ? 'X-RAY DIFFRACTION' 9 7 C 336 C 433 ? . . . . ? 'X-RAY DIFFRACTION' 10 8 C 434 C 440 ? . . . . ? 'X-RAY DIFFRACTION' 11 9 C 441 C 544 ? . . . . ? 'X-RAY DIFFRACTION' 12 10 D 1 D 5 ? . . . . ? 'X-RAY DIFFRACTION' 13 10 D 336 D 433 ? . . . . ? 'X-RAY DIFFRACTION' 14 11 D 434 D 440 ? . . . . ? 'X-RAY DIFFRACTION' 15 12 D 441 D 544 ? . . . . ? # _pdbx_phasing_MR.entry_id 3H9Z _pdbx_phasing_MR.method_rotation ? _pdbx_phasing_MR.method_translation general _pdbx_phasing_MR.model_details ? _pdbx_phasing_MR.R_factor ? _pdbx_phasing_MR.R_rigid_body ? _pdbx_phasing_MR.correlation_coeff_Fo_to_Fc 0.324 _pdbx_phasing_MR.correlation_coeff_Io_to_Ic ? _pdbx_phasing_MR.d_res_high_rotation ? _pdbx_phasing_MR.d_res_low_rotation ? _pdbx_phasing_MR.d_res_high_translation 4.000 _pdbx_phasing_MR.d_res_low_translation 30.000 _pdbx_phasing_MR.packing 0.554 _pdbx_phasing_MR.reflns_percent_rotation ? _pdbx_phasing_MR.reflns_percent_translation 99.900 _pdbx_phasing_MR.sigma_F_rotation ? _pdbx_phasing_MR.sigma_F_translation 0.000 _pdbx_phasing_MR.sigma_I_rotation ? _pdbx_phasing_MR.sigma_I_translation ? # _phasing.method MR # loop_ _software.pdbx_ordinal _software.name _software.version _software.date _software.type _software.contact_author _software.contact_author_email _software.classification _software.location _software.language _software.citation_id 1 DENZO . ? program 'Zbyszek Otwinowski' hkl@hkl-xray.com 'data reduction' http://www.hkl-xray.com/ ? ? 2 SCALEPACK . ? package 'Zbyszek Otwinowski' hkl@hkl-xray.com 'data scaling' http://www.hkl-xray.com/ ? ? 3 CNS . ? package 'Axel T. Brunger' axel.brunger@yale.edu refinement http://cns-online.org/ Fortran_77 ? 4 REFMAC . ? program 'Garib N. Murshudov' garib@ysbl.york.ac.uk refinement http://www.ccp4.ac.uk/dist/html/refmac5.html Fortran_77 ? 5 PDB_EXTRACT 3.005 'June 11, 2008' package PDB help@deposit.rcsb.org 'data extraction' http://sw-tools.pdb.org/apps/PDB_EXTRACT/ C++ ? 6 MAR345 CCD ? ? ? ? 'data collection' ? ? ? 7 CNS . ? ? ? ? phasing ? ? ? # _pdbx_validate_rmsd_angle.id 1 _pdbx_validate_rmsd_angle.PDB_model_num 1 _pdbx_validate_rmsd_angle.auth_atom_id_1 NE _pdbx_validate_rmsd_angle.auth_asym_id_1 B _pdbx_validate_rmsd_angle.auth_comp_id_1 ARG _pdbx_validate_rmsd_angle.auth_seq_id_1 376 _pdbx_validate_rmsd_angle.PDB_ins_code_1 ? _pdbx_validate_rmsd_angle.label_alt_id_1 ? _pdbx_validate_rmsd_angle.auth_atom_id_2 CZ _pdbx_validate_rmsd_angle.auth_asym_id_2 B _pdbx_validate_rmsd_angle.auth_comp_id_2 ARG _pdbx_validate_rmsd_angle.auth_seq_id_2 376 _pdbx_validate_rmsd_angle.PDB_ins_code_2 ? _pdbx_validate_rmsd_angle.label_alt_id_2 ? _pdbx_validate_rmsd_angle.auth_atom_id_3 NH2 _pdbx_validate_rmsd_angle.auth_asym_id_3 B _pdbx_validate_rmsd_angle.auth_comp_id_3 ARG _pdbx_validate_rmsd_angle.auth_seq_id_3 376 _pdbx_validate_rmsd_angle.PDB_ins_code_3 ? _pdbx_validate_rmsd_angle.label_alt_id_3 ? _pdbx_validate_rmsd_angle.angle_value 117.05 _pdbx_validate_rmsd_angle.angle_target_value 120.30 _pdbx_validate_rmsd_angle.angle_deviation -3.25 _pdbx_validate_rmsd_angle.angle_standard_deviation 0.50 _pdbx_validate_rmsd_angle.linker_flag N # loop_ _pdbx_validate_torsion.id _pdbx_validate_torsion.PDB_model_num _pdbx_validate_torsion.auth_comp_id _pdbx_validate_torsion.auth_asym_id _pdbx_validate_torsion.auth_seq_id _pdbx_validate_torsion.PDB_ins_code _pdbx_validate_torsion.label_alt_id _pdbx_validate_torsion.phi _pdbx_validate_torsion.psi 1 1 ILE A 350 ? ? -91.27 -60.07 2 1 PRO A 365 ? ? -56.31 95.21 3 1 HIS A 424 ? ? -96.77 55.41 4 1 PRO A 471 ? ? -67.45 -175.30 5 1 GLU A 482 ? ? 55.54 18.57 6 1 LYS A 519 ? ? -175.27 116.00 7 1 GLU A 521 ? ? -161.10 119.92 8 1 ASP B 362 ? ? 74.04 43.88 9 1 LEU B 363 ? ? -103.83 68.02 10 1 LYS B 367 ? ? -160.60 63.88 11 1 THR B 369 ? ? -176.93 52.69 12 1 ARG B 393 ? ? -78.50 29.36 13 1 HIS B 424 ? ? -91.91 37.14 14 1 SER B 456 ? ? -157.56 53.03 15 1 LYS B 519 ? ? -162.28 111.02 16 1 ILE C 350 ? ? -97.31 -62.94 17 1 LYS C 367 ? ? -49.02 85.76 18 1 LEU C 425 ? ? -170.27 142.98 19 1 PRO C 471 ? ? -72.13 -168.12 20 1 HIS D 424 ? ? -79.58 28.38 21 1 SER D 437 ? ? -105.51 -165.24 22 1 PRO D 471 ? ? -70.22 -168.21 23 1 GLN D 535 ? ? 35.06 49.16 # loop_ _pdbx_unobs_or_zero_occ_residues.id _pdbx_unobs_or_zero_occ_residues.PDB_model_num _pdbx_unobs_or_zero_occ_residues.polymer_flag _pdbx_unobs_or_zero_occ_residues.occupancy_flag _pdbx_unobs_or_zero_occ_residues.auth_asym_id _pdbx_unobs_or_zero_occ_residues.auth_comp_id _pdbx_unobs_or_zero_occ_residues.auth_seq_id _pdbx_unobs_or_zero_occ_residues.PDB_ins_code _pdbx_unobs_or_zero_occ_residues.label_asym_id _pdbx_unobs_or_zero_occ_residues.label_comp_id _pdbx_unobs_or_zero_occ_residues.label_seq_id 1 1 Y 1 A ALA 325 ? A ALA 1 2 1 Y 1 A ASP 326 ? A ASP 2 3 1 Y 1 A PRO 327 ? A PRO 3 4 1 Y 1 A CYS 328 ? A CYS 4 5 1 Y 1 A ALA 329 ? A ALA 5 6 1 Y 1 A ASP 330 ? A ASP 6 7 1 Y 1 A SER 331 ? A SER 7 8 1 Y 1 A ASN 332 ? A ASN 8 9 1 Y 1 A PRO 333 ? A PRO 9 10 1 Y 1 A ARG 334 ? A ARG 10 11 1 Y 1 A GLY 335 ? A GLY 11 12 1 Y 1 A PRO 545 ? A PRO 221 13 1 Y 1 A GLY 546 ? A GLY 222 14 1 Y 1 A LYS 547 ? A LYS 223 15 1 Y 1 B ALA 325 ? B ALA 1 16 1 Y 1 B ASP 326 ? B ASP 2 17 1 Y 1 B PRO 327 ? B PRO 3 18 1 Y 1 B CYS 328 ? B CYS 4 19 1 Y 1 B ALA 329 ? B ALA 5 20 1 Y 1 B ASP 330 ? B ASP 6 21 1 Y 1 B SER 331 ? B SER 7 22 1 Y 1 B ASN 332 ? B ASN 8 23 1 Y 1 B PRO 333 ? B PRO 9 24 1 Y 1 B ARG 334 ? B ARG 10 25 1 Y 1 B GLY 335 ? B GLY 11 26 1 Y 1 B PRO 545 ? B PRO 221 27 1 Y 1 B GLY 546 ? B GLY 222 28 1 Y 1 B LYS 547 ? B LYS 223 29 1 Y 1 C ALA 325 ? C ALA 1 30 1 Y 1 C ASP 326 ? C ASP 2 31 1 Y 1 C PRO 327 ? C PRO 3 32 1 Y 1 C CYS 328 ? C CYS 4 33 1 Y 1 C ALA 329 ? C ALA 5 34 1 Y 1 C ASP 330 ? C ASP 6 35 1 Y 1 C SER 331 ? C SER 7 36 1 Y 1 C ASN 332 ? C ASN 8 37 1 Y 1 C PRO 333 ? C PRO 9 38 1 Y 1 C ARG 334 ? C ARG 10 39 1 Y 1 C GLY 335 ? C GLY 11 40 1 Y 1 C PRO 545 ? C PRO 221 41 1 Y 1 C GLY 546 ? C GLY 222 42 1 Y 1 C LYS 547 ? C LYS 223 43 1 Y 1 D ALA 325 ? D ALA 1 44 1 Y 1 D ASP 326 ? D ASP 2 45 1 Y 1 D PRO 327 ? D PRO 3 46 1 Y 1 D CYS 328 ? D CYS 4 47 1 Y 1 D ALA 329 ? D ALA 5 48 1 Y 1 D ASP 330 ? D ASP 6 49 1 Y 1 D SER 331 ? D SER 7 50 1 Y 1 D ASN 332 ? D ASN 8 51 1 Y 1 D PRO 333 ? D PRO 9 52 1 Y 1 D ARG 334 ? D ARG 10 53 1 Y 1 D GLY 335 ? D GLY 11 54 1 Y 1 D PRO 545 ? D PRO 221 55 1 Y 1 D GLY 546 ? D GLY 222 56 1 Y 1 D LYS 547 ? D LYS 223 # loop_ _pdbx_entity_nonpoly.entity_id _pdbx_entity_nonpoly.name _pdbx_entity_nonpoly.comp_id 2 N-ACETYL-D-GLUCOSAMINE NAG 3 BETA-D-MANNOSE BMA 4 ALPHA-D-MANNOSE MAN 5 'AMMONIUM ION' NH4 6 water HOH #