data_2YDQ # _entry.id 2YDQ # _audit_conform.dict_name mmcif_pdbx.dic _audit_conform.dict_version 5.279 _audit_conform.dict_location http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic # loop_ _database_2.database_id _database_2.database_code PDB 2YDQ PDBE EBI-47794 WWPDB D_1290047794 # loop_ _pdbx_database_related.db_name _pdbx_database_related.db_id _pdbx_database_related.content_type _pdbx_database_related.details PDB 2CBI unspecified 'STRUCTURE OF THE CLOSTRIDIUM PERFRINGENS NAGJ FAMILY 84 GLYCOSIDE HYDROLASE, A HOMOLOGUE OF HUMAN O-GLCNACASE' PDB 2VUR unspecified 'CHEMICAL DISSECTION OF THE LINK BETWEEN STREPTOZOTOCIN, O-GLCNAC AND PANCREATIC CELL DEATH' PDB 2X0Y unspecified 'SCREENING-BASED DISCOVERY OF DRUG-LIKE O-GLCNACASE INHIBITOR SCAFFOLDS' PDB 2XPK unspecified 'CELL-PENETRANT, NANOMOLAR O-GLCNACASE INHIBITORS SELECTIVE AGAINST LYSOSOMAL HEXOSAMINIDASES' PDB 2J62 unspecified 'STRUCTURE OF A BACTERIAL O-GLCNACASE IN COMPLEX WITH GLCNACSTATIN' PDB 2JH2 unspecified 'X-RAY CRYSTAL STRUCTURE OF A COHESIN-LIKE MODULE FROM CLOSTRIDIUM PERFRINGENS' PDB 2WB5 unspecified 'GLCNACSTATINS ARE NANOMOLAR INHIBITORS OF HUMAN O- GLCNACASE INDUCING CELLULAR HYPER-O-GLCNACYLATION' PDB 2V5C unspecified 'FAMILY 84 GLYCOSIDE HYDROLASE FROM CLOSTRIDIUM PERFRINGENS , 2.1 ANGSTROM STRUCTURE' PDB 2CBJ unspecified ;STRUCTURE OF THE CLOSTRIDIUM PERFRINGENS NAGJ FAMILY 84 GLYCOSIDE HYDROLASE, A HOMOLOGUE OF HUMAN O-GLCNACASE IN COMPLEX WITH PUGNAC ; PDB 2V5D unspecified 'STRUCTURE OF A FAMILY 84 GLYCOSIDE HYDROLASE AND A FAMILY 32 CARBOHYDRATE-BINDING MODULE IN TANDEM FROM CLOSTRIDIUM PERFRINGENS.' PDB 2YDS unspecified 'CPOGA D298N IN COMPLEX WITH TAB1-DERIVED O-GLCNAC PEPTIDE' PDB 2YDR unspecified 'CPOGA D298N IN COMPLEX WITH P53-DERIVED O-GLCNAC PEPTIDE' # _pdbx_database_status.status_code REL _pdbx_database_status.entry_id 2YDQ _pdbx_database_status.deposit_site PDBE _pdbx_database_status.process_site PDBE _pdbx_database_status.SG_entry . _pdbx_database_status.recvd_initial_deposition_date 2011-03-24 _pdbx_database_status.pdb_format_compatible Y _pdbx_database_status.status_code_sf ? _pdbx_database_status.status_code_mr ? _pdbx_database_status.status_code_cs ? _pdbx_database_status.methods_development_category ? # loop_ _audit_author.name _audit_author.pdbx_ordinal 'Schimpl, M.' 1 'Borodkin, V.S.' 2 'Gray, L.J.' 3 'van Aalten, D.M.F.' 4 # _citation.id primary _citation.title 'Synergy of Peptide and Sugar in O-Glcnacase Substrate Recognition.' _citation.journal_abbrev Chem.Biol. _citation.journal_volume 19 _citation.page_first 173 _citation.page_last ? _citation.year 2012 _citation.journal_id_ASTM CBOLE2 _citation.country UK _citation.journal_id_ISSN 1074-5521 _citation.journal_id_CSD 2050 _citation.book_publisher ? _citation.pdbx_database_id_PubMed 22365600 _citation.pdbx_database_id_DOI 10.1016/J.CHEMBIOL.2012.01.011 # loop_ _citation_author.citation_id _citation_author.name _citation_author.ordinal primary 'Schimpl, M.' 1 primary 'Borodkin, V.S.' 2 primary 'Gray, L.J.' 3 primary 'Van Aalten, D.M.F.' 4 # _cell.entry_id 2YDQ _cell.length_a 118.210 _cell.length_b 118.210 _cell.length_c 148.210 _cell.angle_alpha 90.00 _cell.angle_beta 90.00 _cell.angle_gamma 120.00 _cell.Z_PDB 6 _cell.pdbx_unique_axis ? # _symmetry.entry_id 2YDQ _symmetry.space_group_name_H-M 'P 61' _symmetry.pdbx_full_space_group_name_H-M ? _symmetry.cell_setting ? _symmetry.Int_Tables_number 169 # loop_ _entity.id _entity.type _entity.src_method _entity.pdbx_description _entity.formula_weight _entity.pdbx_number_of_molecules _entity.pdbx_ec _entity.pdbx_mutation _entity.pdbx_fragment _entity.details 1 polymer man 'O-GLCNACASE NAGJ' 66130.008 1 3.2.1.52 YES 'RESIDUES 31-618' ? 2 polymer syn 'BIFUNCTIONAL PROTEIN NCOAT' 670.758 1 3.2.1.169 ? 'HOGA O-GLCNAC PEPTIDE, RESIDUES 402-408' 'O-GLCNAC GLYCOSYLATION ON S405' 3 non-polymer syn 'CADMIUM ION' 112.411 19 ? ? ? ? 4 non-polymer man N-ACETYL-D-GLUCOSAMINE 221.208 1 ? ? ? ? 5 water nat water 18.015 104 ? ? ? ? # loop_ _entity_name_com.entity_id _entity_name_com.name 1 'O-GLCNACASE, CPNAGJ, BETA-N-ACETYLHEXOSAMINIDASE, GH84, BETA-HEXOSAMINIDASE, HEXOSAMINIDASE B, N-ACETYL-BETA-GLUCOSAMINIDASE' 2 ;MENINGIOMA-EXPRESSED ANTIGEN 5, NUCLEAR CYTOPLASMIC O-GLCNACASE AND ACETYLTRANSFERASE, PROTEIN O-GLCNACASE, GLYCOSIDE HYDROLASE O-GLCNACASE, HEXOSAMINIDASE C, N-ACETYL-BETA-D-GLUCOSAMINIDASE, N-ACETYL-BETA-GLUCOSAMINIDASE, O-GLCNACASE, OGA ; # loop_ _entity_poly.entity_id _entity_poly.type _entity_poly.nstd_linkage _entity_poly.nstd_monomer _entity_poly.pdbx_seq_one_letter_code _entity_poly.pdbx_seq_one_letter_code_can _entity_poly.pdbx_strand_id _entity_poly.pdbx_target_identifier 1 'polypeptide(L)' no no ;GSVGPKTGEENQVLVPNLNPTPENLEVVGDGFKITSSINLVGEEEADENAVNALREFLTANNIEINSENDPNSTTLIIGE VDDDIPELDEALNGTTAENLKEEGYALVSNDGKIAIEGKDGDGTFYGVQTFKQLVKESNIPEVNITDYPTVSARGIVEGF YGTPWTHQDRLDQIKFYGENKLNTYIYAPKDDPYHREKWREPYPESEMQRMQELINASAENKVDFVFGISPGIDIRFDGD AGEEDFNHLITKAESLYDMGVRSFAIYWDNIQDKSAAKHAQVLNRFNEEFVKAKGDVKPLITVPTEYDTGAMVSNGQPRA YTRIFAETVDPSIEVMWTGPGVVTNEIPLSDAQLISGIYDRNMAVWWNYPVTDYFKGKLALGPMHGLDKGLNQYVDFFTV NPMEHAELSKISIHTAADYSWNMDNYDYDKAWNRAIDMLYGDLAEDMKVFANHSTRMDNKTWAKSGREDAPELRAKMDEL WNKLSSKEDASALIEELYGEFARMEEACNNLKANLPEVALEECSRQLDELITLAQGDKASLDMIVAQLNEDTEAYESAKE IAQNKLNTALSSFAVISEKVAQSFIQEALS ; ;GSVGPKTGEENQVLVPNLNPTPENLEVVGDGFKITSSINLVGEEEADENAVNALREFLTANNIEINSENDPNSTTLIIGE VDDDIPELDEALNGTTAENLKEEGYALVSNDGKIAIEGKDGDGTFYGVQTFKQLVKESNIPEVNITDYPTVSARGIVEGF YGTPWTHQDRLDQIKFYGENKLNTYIYAPKDDPYHREKWREPYPESEMQRMQELINASAENKVDFVFGISPGIDIRFDGD AGEEDFNHLITKAESLYDMGVRSFAIYWDNIQDKSAAKHAQVLNRFNEEFVKAKGDVKPLITVPTEYDTGAMVSNGQPRA YTRIFAETVDPSIEVMWTGPGVVTNEIPLSDAQLISGIYDRNMAVWWNYPVTDYFKGKLALGPMHGLDKGLNQYVDFFTV NPMEHAELSKISIHTAADYSWNMDNYDYDKAWNRAIDMLYGDLAEDMKVFANHSTRMDNKTWAKSGREDAPELRAKMDEL WNKLSSKEDASALIEELYGEFARMEEACNNLKANLPEVALEECSRQLDELITLAQGDKASLDMIVAQLNEDTEAYESAKE IAQNKLNTALSSFAVISEKVAQSFIQEALS ; A ? 2 'polypeptide(L)' no no VAHSGAK VAHSGAK T ? # loop_ _entity_poly_seq.entity_id _entity_poly_seq.num _entity_poly_seq.mon_id _entity_poly_seq.hetero 1 1 GLY n 1 2 SER n 1 3 VAL n 1 4 GLY n 1 5 PRO n 1 6 LYS n 1 7 THR n 1 8 GLY n 1 9 GLU n 1 10 GLU n 1 11 ASN n 1 12 GLN n 1 13 VAL n 1 14 LEU n 1 15 VAL n 1 16 PRO n 1 17 ASN n 1 18 LEU n 1 19 ASN n 1 20 PRO n 1 21 THR n 1 22 PRO n 1 23 GLU n 1 24 ASN n 1 25 LEU n 1 26 GLU n 1 27 VAL n 1 28 VAL n 1 29 GLY n 1 30 ASP n 1 31 GLY n 1 32 PHE n 1 33 LYS n 1 34 ILE n 1 35 THR n 1 36 SER n 1 37 SER n 1 38 ILE n 1 39 ASN n 1 40 LEU n 1 41 VAL n 1 42 GLY n 1 43 GLU n 1 44 GLU n 1 45 GLU n 1 46 ALA n 1 47 ASP n 1 48 GLU n 1 49 ASN n 1 50 ALA n 1 51 VAL n 1 52 ASN n 1 53 ALA n 1 54 LEU n 1 55 ARG n 1 56 GLU n 1 57 PHE n 1 58 LEU n 1 59 THR n 1 60 ALA n 1 61 ASN n 1 62 ASN n 1 63 ILE n 1 64 GLU n 1 65 ILE n 1 66 ASN n 1 67 SER n 1 68 GLU n 1 69 ASN n 1 70 ASP n 1 71 PRO n 1 72 ASN n 1 73 SER n 1 74 THR n 1 75 THR n 1 76 LEU n 1 77 ILE n 1 78 ILE n 1 79 GLY n 1 80 GLU n 1 81 VAL n 1 82 ASP n 1 83 ASP n 1 84 ASP n 1 85 ILE n 1 86 PRO n 1 87 GLU n 1 88 LEU n 1 89 ASP n 1 90 GLU n 1 91 ALA n 1 92 LEU n 1 93 ASN n 1 94 GLY n 1 95 THR n 1 96 THR n 1 97 ALA n 1 98 GLU n 1 99 ASN n 1 100 LEU n 1 101 LYS n 1 102 GLU n 1 103 GLU n 1 104 GLY n 1 105 TYR n 1 106 ALA n 1 107 LEU n 1 108 VAL n 1 109 SER n 1 110 ASN n 1 111 ASP n 1 112 GLY n 1 113 LYS n 1 114 ILE n 1 115 ALA n 1 116 ILE n 1 117 GLU n 1 118 GLY n 1 119 LYS n 1 120 ASP n 1 121 GLY n 1 122 ASP n 1 123 GLY n 1 124 THR n 1 125 PHE n 1 126 TYR n 1 127 GLY n 1 128 VAL n 1 129 GLN n 1 130 THR n 1 131 PHE n 1 132 LYS n 1 133 GLN n 1 134 LEU n 1 135 VAL n 1 136 LYS n 1 137 GLU n 1 138 SER n 1 139 ASN n 1 140 ILE n 1 141 PRO n 1 142 GLU n 1 143 VAL n 1 144 ASN n 1 145 ILE n 1 146 THR n 1 147 ASP n 1 148 TYR n 1 149 PRO n 1 150 THR n 1 151 VAL n 1 152 SER n 1 153 ALA n 1 154 ARG n 1 155 GLY n 1 156 ILE n 1 157 VAL n 1 158 GLU n 1 159 GLY n 1 160 PHE n 1 161 TYR n 1 162 GLY n 1 163 THR n 1 164 PRO n 1 165 TRP n 1 166 THR n 1 167 HIS n 1 168 GLN n 1 169 ASP n 1 170 ARG n 1 171 LEU n 1 172 ASP n 1 173 GLN n 1 174 ILE n 1 175 LYS n 1 176 PHE n 1 177 TYR n 1 178 GLY n 1 179 GLU n 1 180 ASN n 1 181 LYS n 1 182 LEU n 1 183 ASN n 1 184 THR n 1 185 TYR n 1 186 ILE n 1 187 TYR n 1 188 ALA n 1 189 PRO n 1 190 LYS n 1 191 ASP n 1 192 ASP n 1 193 PRO n 1 194 TYR n 1 195 HIS n 1 196 ARG n 1 197 GLU n 1 198 LYS n 1 199 TRP n 1 200 ARG n 1 201 GLU n 1 202 PRO n 1 203 TYR n 1 204 PRO n 1 205 GLU n 1 206 SER n 1 207 GLU n 1 208 MET n 1 209 GLN n 1 210 ARG n 1 211 MET n 1 212 GLN n 1 213 GLU n 1 214 LEU n 1 215 ILE n 1 216 ASN n 1 217 ALA n 1 218 SER n 1 219 ALA n 1 220 GLU n 1 221 ASN n 1 222 LYS n 1 223 VAL n 1 224 ASP n 1 225 PHE n 1 226 VAL n 1 227 PHE n 1 228 GLY n 1 229 ILE n 1 230 SER n 1 231 PRO n 1 232 GLY n 1 233 ILE n 1 234 ASP n 1 235 ILE n 1 236 ARG n 1 237 PHE n 1 238 ASP n 1 239 GLY n 1 240 ASP n 1 241 ALA n 1 242 GLY n 1 243 GLU n 1 244 GLU n 1 245 ASP n 1 246 PHE n 1 247 ASN n 1 248 HIS n 1 249 LEU n 1 250 ILE n 1 251 THR n 1 252 LYS n 1 253 ALA n 1 254 GLU n 1 255 SER n 1 256 LEU n 1 257 TYR n 1 258 ASP n 1 259 MET n 1 260 GLY n 1 261 VAL n 1 262 ARG n 1 263 SER n 1 264 PHE n 1 265 ALA n 1 266 ILE n 1 267 TYR n 1 268 TRP n 1 269 ASP n 1 270 ASN n 1 271 ILE n 1 272 GLN n 1 273 ASP n 1 274 LYS n 1 275 SER n 1 276 ALA n 1 277 ALA n 1 278 LYS n 1 279 HIS n 1 280 ALA n 1 281 GLN n 1 282 VAL n 1 283 LEU n 1 284 ASN n 1 285 ARG n 1 286 PHE n 1 287 ASN n 1 288 GLU n 1 289 GLU n 1 290 PHE n 1 291 VAL n 1 292 LYS n 1 293 ALA n 1 294 LYS n 1 295 GLY n 1 296 ASP n 1 297 VAL n 1 298 LYS n 1 299 PRO n 1 300 LEU n 1 301 ILE n 1 302 THR n 1 303 VAL n 1 304 PRO n 1 305 THR n 1 306 GLU n 1 307 TYR n 1 308 ASP n 1 309 THR n 1 310 GLY n 1 311 ALA n 1 312 MET n 1 313 VAL n 1 314 SER n 1 315 ASN n 1 316 GLY n 1 317 GLN n 1 318 PRO n 1 319 ARG n 1 320 ALA n 1 321 TYR n 1 322 THR n 1 323 ARG n 1 324 ILE n 1 325 PHE n 1 326 ALA n 1 327 GLU n 1 328 THR n 1 329 VAL n 1 330 ASP n 1 331 PRO n 1 332 SER n 1 333 ILE n 1 334 GLU n 1 335 VAL n 1 336 MET n 1 337 TRP n 1 338 THR n 1 339 GLY n 1 340 PRO n 1 341 GLY n 1 342 VAL n 1 343 VAL n 1 344 THR n 1 345 ASN n 1 346 GLU n 1 347 ILE n 1 348 PRO n 1 349 LEU n 1 350 SER n 1 351 ASP n 1 352 ALA n 1 353 GLN n 1 354 LEU n 1 355 ILE n 1 356 SER n 1 357 GLY n 1 358 ILE n 1 359 TYR n 1 360 ASP n 1 361 ARG n 1 362 ASN n 1 363 MET n 1 364 ALA n 1 365 VAL n 1 366 TRP n 1 367 TRP n 1 368 ASN n 1 369 TYR n 1 370 PRO n 1 371 VAL n 1 372 THR n 1 373 ASP n 1 374 TYR n 1 375 PHE n 1 376 LYS n 1 377 GLY n 1 378 LYS n 1 379 LEU n 1 380 ALA n 1 381 LEU n 1 382 GLY n 1 383 PRO n 1 384 MET n 1 385 HIS n 1 386 GLY n 1 387 LEU n 1 388 ASP n 1 389 LYS n 1 390 GLY n 1 391 LEU n 1 392 ASN n 1 393 GLN n 1 394 TYR n 1 395 VAL n 1 396 ASP n 1 397 PHE n 1 398 PHE n 1 399 THR n 1 400 VAL n 1 401 ASN n 1 402 PRO n 1 403 MET n 1 404 GLU n 1 405 HIS n 1 406 ALA n 1 407 GLU n 1 408 LEU n 1 409 SER n 1 410 LYS n 1 411 ILE n 1 412 SER n 1 413 ILE n 1 414 HIS n 1 415 THR n 1 416 ALA n 1 417 ALA n 1 418 ASP n 1 419 TYR n 1 420 SER n 1 421 TRP n 1 422 ASN n 1 423 MET n 1 424 ASP n 1 425 ASN n 1 426 TYR n 1 427 ASP n 1 428 TYR n 1 429 ASP n 1 430 LYS n 1 431 ALA n 1 432 TRP n 1 433 ASN n 1 434 ARG n 1 435 ALA n 1 436 ILE n 1 437 ASP n 1 438 MET n 1 439 LEU n 1 440 TYR n 1 441 GLY n 1 442 ASP n 1 443 LEU n 1 444 ALA n 1 445 GLU n 1 446 ASP n 1 447 MET n 1 448 LYS n 1 449 VAL n 1 450 PHE n 1 451 ALA n 1 452 ASN n 1 453 HIS n 1 454 SER n 1 455 THR n 1 456 ARG n 1 457 MET n 1 458 ASP n 1 459 ASN n 1 460 LYS n 1 461 THR n 1 462 TRP n 1 463 ALA n 1 464 LYS n 1 465 SER n 1 466 GLY n 1 467 ARG n 1 468 GLU n 1 469 ASP n 1 470 ALA n 1 471 PRO n 1 472 GLU n 1 473 LEU n 1 474 ARG n 1 475 ALA n 1 476 LYS n 1 477 MET n 1 478 ASP n 1 479 GLU n 1 480 LEU n 1 481 TRP n 1 482 ASN n 1 483 LYS n 1 484 LEU n 1 485 SER n 1 486 SER n 1 487 LYS n 1 488 GLU n 1 489 ASP n 1 490 ALA n 1 491 SER n 1 492 ALA n 1 493 LEU n 1 494 ILE n 1 495 GLU n 1 496 GLU n 1 497 LEU n 1 498 TYR n 1 499 GLY n 1 500 GLU n 1 501 PHE n 1 502 ALA n 1 503 ARG n 1 504 MET n 1 505 GLU n 1 506 GLU n 1 507 ALA n 1 508 CYS n 1 509 ASN n 1 510 ASN n 1 511 LEU n 1 512 LYS n 1 513 ALA n 1 514 ASN n 1 515 LEU n 1 516 PRO n 1 517 GLU n 1 518 VAL n 1 519 ALA n 1 520 LEU n 1 521 GLU n 1 522 GLU n 1 523 CYS n 1 524 SER n 1 525 ARG n 1 526 GLN n 1 527 LEU n 1 528 ASP n 1 529 GLU n 1 530 LEU n 1 531 ILE n 1 532 THR n 1 533 LEU n 1 534 ALA n 1 535 GLN n 1 536 GLY n 1 537 ASP n 1 538 LYS n 1 539 ALA n 1 540 SER n 1 541 LEU n 1 542 ASP n 1 543 MET n 1 544 ILE n 1 545 VAL n 1 546 ALA n 1 547 GLN n 1 548 LEU n 1 549 ASN n 1 550 GLU n 1 551 ASP n 1 552 THR n 1 553 GLU n 1 554 ALA n 1 555 TYR n 1 556 GLU n 1 557 SER n 1 558 ALA n 1 559 LYS n 1 560 GLU n 1 561 ILE n 1 562 ALA n 1 563 GLN n 1 564 ASN n 1 565 LYS n 1 566 LEU n 1 567 ASN n 1 568 THR n 1 569 ALA n 1 570 LEU n 1 571 SER n 1 572 SER n 1 573 PHE n 1 574 ALA n 1 575 VAL n 1 576 ILE n 1 577 SER n 1 578 GLU n 1 579 LYS n 1 580 VAL n 1 581 ALA n 1 582 GLN n 1 583 SER n 1 584 PHE n 1 585 ILE n 1 586 GLN n 1 587 GLU n 1 588 ALA n 1 589 LEU n 1 590 SER n 2 1 VAL n 2 2 ALA n 2 3 HIS n 2 4 SER n 2 5 GLY n 2 6 ALA n 2 7 LYS n # _entity_src_gen.entity_id 1 _entity_src_gen.pdbx_src_id 1 _entity_src_gen.pdbx_alt_source_flag sample _entity_src_gen.pdbx_seq_type ? _entity_src_gen.pdbx_beg_seq_num ? _entity_src_gen.pdbx_end_seq_num ? _entity_src_gen.gene_src_common_name ? _entity_src_gen.gene_src_genus ? _entity_src_gen.pdbx_gene_src_gene ? _entity_src_gen.gene_src_species ? _entity_src_gen.gene_src_strain ? _entity_src_gen.gene_src_tissue ? _entity_src_gen.gene_src_tissue_fraction ? _entity_src_gen.gene_src_details ? _entity_src_gen.pdbx_gene_src_fragment ? _entity_src_gen.pdbx_gene_src_scientific_name 'CLOSTRIDIUM PERFRINGENS' _entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 1502 _entity_src_gen.pdbx_gene_src_variant ? _entity_src_gen.pdbx_gene_src_cell_line ? _entity_src_gen.pdbx_gene_src_atcc ? _entity_src_gen.pdbx_gene_src_organ ? _entity_src_gen.pdbx_gene_src_organelle ? _entity_src_gen.pdbx_gene_src_cell ? _entity_src_gen.pdbx_gene_src_cellular_location ? _entity_src_gen.host_org_common_name ? _entity_src_gen.pdbx_host_org_scientific_name 'ESCHERICHIA COLI' _entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 469008 _entity_src_gen.host_org_genus ? _entity_src_gen.pdbx_host_org_gene ? _entity_src_gen.pdbx_host_org_organ ? _entity_src_gen.host_org_species ? _entity_src_gen.pdbx_host_org_tissue ? _entity_src_gen.pdbx_host_org_tissue_fraction ? _entity_src_gen.pdbx_host_org_strain 'BL21(DE3)' _entity_src_gen.pdbx_host_org_variant PLYSS _entity_src_gen.pdbx_host_org_cell_line ? _entity_src_gen.pdbx_host_org_atcc ? _entity_src_gen.pdbx_host_org_culture_collection ? _entity_src_gen.pdbx_host_org_cell ? _entity_src_gen.pdbx_host_org_organelle ? _entity_src_gen.pdbx_host_org_cellular_location ? _entity_src_gen.pdbx_host_org_vector_type PLASMID _entity_src_gen.pdbx_host_org_vector ? _entity_src_gen.host_org_details ? _entity_src_gen.expression_system_id ? _entity_src_gen.plasmid_name PGEX6P-1 _entity_src_gen.plasmid_details ? _entity_src_gen.pdbx_description ? # _pdbx_entity_src_syn.entity_id 2 _pdbx_entity_src_syn.pdbx_src_id 1 _pdbx_entity_src_syn.pdbx_alt_source_flag sample _pdbx_entity_src_syn.pdbx_beg_seq_num ? _pdbx_entity_src_syn.pdbx_end_seq_num ? _pdbx_entity_src_syn.organism_scientific 'HOMO SAPIENS' _pdbx_entity_src_syn.organism_common_name HUMAN _pdbx_entity_src_syn.ncbi_taxonomy_id 9606 _pdbx_entity_src_syn.details ? # loop_ _struct_ref.id _struct_ref.db_name _struct_ref.db_code _struct_ref.entity_id _struct_ref.pdbx_seq_one_letter_code _struct_ref.pdbx_align_begin _struct_ref.pdbx_db_accession _struct_ref.pdbx_db_isoform 1 UNP OGA_CLOP1 1 ? ? Q0TR53 ? 2 UNP NCOAT_HUMAN 2 ? ? O60502 ? # loop_ _struct_ref_seq.align_id _struct_ref_seq.ref_id _struct_ref_seq.pdbx_PDB_id_code _struct_ref_seq.pdbx_strand_id _struct_ref_seq.seq_align_beg _struct_ref_seq.pdbx_seq_align_beg_ins_code _struct_ref_seq.seq_align_end _struct_ref_seq.pdbx_seq_align_end_ins_code _struct_ref_seq.pdbx_db_accession _struct_ref_seq.db_align_beg _struct_ref_seq.pdbx_db_align_beg_ins_code _struct_ref_seq.db_align_end _struct_ref_seq.pdbx_db_align_end_ins_code _struct_ref_seq.pdbx_auth_seq_align_beg _struct_ref_seq.pdbx_auth_seq_align_end 1 1 2YDQ A 3 ? 590 ? Q0TR53 31 ? 618 ? 31 618 2 2 2YDQ T 1 ? 7 ? O60502 402 ? 408 ? 402 408 # loop_ _struct_ref_seq_dif.align_id _struct_ref_seq_dif.pdbx_pdb_id_code _struct_ref_seq_dif.mon_id _struct_ref_seq_dif.pdbx_pdb_strand_id _struct_ref_seq_dif.seq_num _struct_ref_seq_dif.pdbx_pdb_ins_code _struct_ref_seq_dif.pdbx_seq_db_name _struct_ref_seq_dif.pdbx_seq_db_accession_code _struct_ref_seq_dif.db_mon_id _struct_ref_seq_dif.pdbx_seq_db_seq_num _struct_ref_seq_dif.details _struct_ref_seq_dif.pdbx_auth_seq_num _struct_ref_seq_dif.pdbx_ordinal 1 2YDQ GLY A 1 ? UNP Q0TR53 ? ? 'expression tag' 29 1 1 2YDQ SER A 2 ? UNP Q0TR53 ? ? 'expression tag' 30 2 1 2YDQ ASN A 270 ? UNP Q0TR53 ASP 298 'engineered mutation' 298 3 1 2YDQ ASP A 360 ? UNP Q0TR53 ASN 388 'engineered mutation' 388 4 # loop_ _chem_comp.id _chem_comp.type _chem_comp.mon_nstd_flag _chem_comp.name _chem_comp.pdbx_synonyms _chem_comp.formula _chem_comp.formula_weight ALA 'L-peptide linking' y ALANINE ? 'C3 H7 N O2' 89.093 ARG 'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1' 175.209 ASN 'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3' 132.118 ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4' 133.103 CD non-polymer . 'CADMIUM ION' ? 'Cd 2' 112.411 CYS 'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S' 121.158 GLN 'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3' 146.144 GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4' 147.129 GLY 'peptide linking' y GLYCINE ? 'C2 H5 N O2' 75.067 HIS 'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1' 156.162 HOH non-polymer . WATER ? 'H2 O' 18.015 ILE 'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2' 131.173 LEU 'L-peptide linking' y LEUCINE ? 'C6 H13 N O2' 131.173 LYS 'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1' 147.195 MET 'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S' 149.211 NAG D-saccharide . N-ACETYL-D-GLUCOSAMINE ? 'C8 H15 N O6' 221.208 PHE 'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2' 165.189 PRO 'L-peptide linking' y PROLINE ? 'C5 H9 N O2' 115.130 SER 'L-peptide linking' y SERINE ? 'C3 H7 N O3' 105.093 THR 'L-peptide linking' y THREONINE ? 'C4 H9 N O3' 119.119 TRP 'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2' 204.225 TYR 'L-peptide linking' y TYROSINE ? 'C9 H11 N O3' 181.189 VAL 'L-peptide linking' y VALINE ? 'C5 H11 N O2' 117.146 # _exptl.entry_id 2YDQ _exptl.method 'X-RAY DIFFRACTION' _exptl.crystals_number 1 # _exptl_crystal.id 1 _exptl_crystal.density_meas ? _exptl_crystal.density_Matthews 4.5 _exptl_crystal.density_percent_sol 72 _exptl_crystal.description NONE # _exptl_crystal_grow.crystal_id 1 _exptl_crystal_grow.method ? _exptl_crystal_grow.temp ? _exptl_crystal_grow.temp_details ? _exptl_crystal_grow.pH 8.5 _exptl_crystal_grow.pdbx_pH_range ? _exptl_crystal_grow.pdbx_details '0.6M NAAC, 0.175M CDSO4, 0.1M HEPES PH 7.5' # _diffrn.id 1 _diffrn.ambient_temp 100 _diffrn.ambient_temp_details ? _diffrn.crystal_id 1 # _diffrn_detector.diffrn_id 1 _diffrn_detector.detector CCD _diffrn_detector.type 'ADSC QUANTUM 210' _diffrn_detector.pdbx_collection_date 2010-07-22 _diffrn_detector.details ? # _diffrn_radiation.diffrn_id 1 _diffrn_radiation.wavelength_id 1 _diffrn_radiation.pdbx_monochromatic_or_laue_m_l M _diffrn_radiation.monochromator ? _diffrn_radiation.pdbx_diffrn_protocol 'SINGLE WAVELENGTH' _diffrn_radiation.pdbx_scattering_type x-ray # _diffrn_radiation_wavelength.id 1 _diffrn_radiation_wavelength.wavelength 0.934 _diffrn_radiation_wavelength.wt 1.0 # _diffrn_source.diffrn_id 1 _diffrn_source.source SYNCHROTRON _diffrn_source.type 'ESRF BEAMLINE ID14-1' _diffrn_source.pdbx_synchrotron_site ESRF _diffrn_source.pdbx_synchrotron_beamline ID14-1 _diffrn_source.pdbx_wavelength 0.934 _diffrn_source.pdbx_wavelength_list ? # _reflns.pdbx_diffrn_id 1 _reflns.pdbx_ordinal 1 _reflns.entry_id 2YDQ _reflns.observed_criterion_sigma_I 2.0 _reflns.observed_criterion_sigma_F ? _reflns.d_resolution_low 25.00 _reflns.d_resolution_high 2.60 _reflns.number_obs 36085 _reflns.number_all ? _reflns.percent_possible_obs 100.0 _reflns.pdbx_Rmerge_I_obs 0.16 _reflns.pdbx_Rsym_value ? _reflns.pdbx_netI_over_sigmaI 36.90 _reflns.B_iso_Wilson_estimate ? _reflns.pdbx_redundancy 7.7 # _refine.pdbx_refine_id 'X-RAY DIFFRACTION' _refine.entry_id 2YDQ _refine.pdbx_diffrn_id 1 _refine.pdbx_TLS_residual_ADP_flag ? _refine.ls_number_reflns_obs 35251 _refine.ls_number_reflns_all ? _refine.pdbx_ls_sigma_I ? _refine.pdbx_ls_sigma_F . _refine.pdbx_data_cutoff_high_absF ? _refine.pdbx_data_cutoff_low_absF ? _refine.pdbx_data_cutoff_high_rms_absF ? _refine.ls_d_res_low 24.70 _refine.ls_d_res_high 2.60 _refine.ls_percent_reflns_obs 99.94 _refine.ls_R_factor_obs 0.19376 _refine.ls_R_factor_all ? _refine.ls_R_factor_R_work 0.19302 _refine.ls_R_factor_R_free 0.23053 _refine.ls_R_factor_R_free_error ? _refine.ls_R_factor_R_free_error_details ? _refine.ls_percent_reflns_R_free 2.0 _refine.ls_number_reflns_R_free 735 _refine.ls_number_parameters ? _refine.ls_number_restraints ? _refine.occupancy_min ? _refine.occupancy_max ? _refine.correlation_coeff_Fo_to_Fc 0.931 _refine.correlation_coeff_Fo_to_Fc_free 0.898 _refine.B_iso_mean 27.199 _refine.aniso_B[1][1] 0.15 _refine.aniso_B[2][2] 0.15 _refine.aniso_B[3][3] -0.23 _refine.aniso_B[1][2] 0.08 _refine.aniso_B[1][3] 0.00 _refine.aniso_B[2][3] 0.00 _refine.solvent_model_details MASK _refine.solvent_model_param_ksol ? _refine.solvent_model_param_bsol ? _refine.pdbx_solvent_vdw_probe_radii 1.40 _refine.pdbx_solvent_ion_probe_radii 0.80 _refine.pdbx_solvent_shrinkage_radii 0.80 _refine.pdbx_ls_cross_valid_method THROUGHOUT _refine.details 'HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS.' _refine.pdbx_starting_model NONE _refine.pdbx_method_to_determine_struct OTHER _refine.pdbx_isotropic_thermal_model ? _refine.pdbx_stereochemistry_target_values 'MAXIMUM LIKELIHOOD' _refine.pdbx_stereochem_target_val_spec_case ? _refine.pdbx_R_Free_selection_details RANDOM _refine.pdbx_overall_ESU_R 0.274 _refine.pdbx_overall_ESU_R_Free 0.222 _refine.overall_SU_ML 0.151 _refine.pdbx_overall_phase_error ? _refine.overall_SU_B 7.392 _refine.overall_SU_R_Cruickshank_DPI ? _refine.pdbx_overall_SU_R_free_Cruickshank_DPI ? _refine.pdbx_overall_SU_R_Blow_DPI ? _refine.pdbx_overall_SU_R_free_Blow_DPI ? # _refine_hist.pdbx_refine_id 'X-RAY DIFFRACTION' _refine_hist.cycle_id LAST _refine_hist.pdbx_number_atoms_protein 4616 _refine_hist.pdbx_number_atoms_nucleic_acid 0 _refine_hist.pdbx_number_atoms_ligand 33 _refine_hist.number_atoms_solvent 104 _refine_hist.number_atoms_total 4753 _refine_hist.d_res_high 2.60 _refine_hist.d_res_low 24.70 # loop_ _refine_ls_restr.type _refine_ls_restr.dev_ideal _refine_ls_restr.dev_ideal_target _refine_ls_restr.weight _refine_ls_restr.number _refine_ls_restr.pdbx_refine_id _refine_ls_restr.pdbx_restraint_function r_bond_refined_d 0.013 0.022 ? 4719 'X-RAY DIFFRACTION' ? r_bond_other_d ? ? ? ? 'X-RAY DIFFRACTION' ? r_angle_refined_deg 1.365 1.953 ? 6406 'X-RAY DIFFRACTION' ? r_angle_other_deg ? ? ? ? 'X-RAY DIFFRACTION' ? r_dihedral_angle_1_deg 5.895 5.000 ? 582 'X-RAY DIFFRACTION' ? r_dihedral_angle_2_deg 39.134 25.909 ? 242 'X-RAY DIFFRACTION' ? r_dihedral_angle_3_deg 15.318 15.000 ? 789 'X-RAY DIFFRACTION' ? r_dihedral_angle_4_deg 15.120 15.000 ? 18 'X-RAY DIFFRACTION' ? r_chiral_restr 0.092 0.200 ? 698 'X-RAY DIFFRACTION' ? r_gen_planes_refined 0.006 0.021 ? 3656 'X-RAY DIFFRACTION' ? r_gen_planes_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_nbd_refined ? ? ? ? 'X-RAY DIFFRACTION' ? r_nbd_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_nbtor_refined ? ? ? ? 'X-RAY DIFFRACTION' ? r_nbtor_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_xyhbond_nbd_refined ? ? ? ? 'X-RAY DIFFRACTION' ? r_xyhbond_nbd_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_metal_ion_refined ? ? ? ? 'X-RAY DIFFRACTION' ? r_metal_ion_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_symmetry_vdw_refined ? ? ? ? 'X-RAY DIFFRACTION' ? r_symmetry_vdw_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_symmetry_hbond_refined ? ? ? ? 'X-RAY DIFFRACTION' ? r_symmetry_hbond_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_symmetry_metal_ion_refined ? ? ? ? 'X-RAY DIFFRACTION' ? r_symmetry_metal_ion_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_mcbond_it 0.599 1.500 ? 2910 'X-RAY DIFFRACTION' ? r_mcbond_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_mcangle_it 1.252 2.000 ? 4684 'X-RAY DIFFRACTION' ? r_mcangle_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_scbond_it 2.074 3.000 ? 1809 'X-RAY DIFFRACTION' ? r_scbond_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_scangle_it 3.655 4.500 ? 1722 'X-RAY DIFFRACTION' ? r_scangle_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_long_range_B_refined ? ? ? ? 'X-RAY DIFFRACTION' ? r_long_range_B_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_rigid_bond_restr ? ? ? ? 'X-RAY DIFFRACTION' ? r_sphericity_free 15.674 3.000 ? 19 'X-RAY DIFFRACTION' ? r_sphericity_bonded ? ? ? ? 'X-RAY DIFFRACTION' ? # _refine_ls_shell.pdbx_refine_id 'X-RAY DIFFRACTION' _refine_ls_shell.pdbx_total_number_of_bins_used 20 _refine_ls_shell.d_res_high 2.601 _refine_ls_shell.d_res_low 2.668 _refine_ls_shell.number_reflns_R_work 2568 _refine_ls_shell.R_factor_R_work 0.268 _refine_ls_shell.percent_reflns_obs 99.47 _refine_ls_shell.R_factor_R_free 0.338 _refine_ls_shell.R_factor_R_free_error ? _refine_ls_shell.percent_reflns_R_free ? _refine_ls_shell.number_reflns_R_free 51 _refine_ls_shell.number_reflns_all ? _refine_ls_shell.R_factor_all ? # _struct.entry_id 2YDQ _struct.title 'CpOGA D298N in complex with hOGA-derived O-GlcNAc peptide' _struct.pdbx_descriptor 'O-GLCNACASE NAGJ (E.C.3.2.1.52), BIFUNCTIONAL PROTEIN NCOAT (E.C.3.2.1.169)' _struct.pdbx_model_details ? _struct.pdbx_CASP_flag ? _struct.pdbx_model_type_details ? # _struct_keywords.entry_id 2YDQ _struct_keywords.pdbx_keywords HYDROLASE/PEPTIDE _struct_keywords.text 'HYDROLASE-PEPTIDE COMPLEX' # loop_ _struct_asym.id _struct_asym.pdbx_blank_PDB_chainid_flag _struct_asym.pdbx_modified _struct_asym.entity_id _struct_asym.details A N N 1 ? B N N 2 ? C N N 3 ? D N N 3 ? E N N 3 ? F N N 3 ? G N N 3 ? H N N 3 ? I N N 3 ? J N N 3 ? K N N 3 ? L N N 3 ? M N N 3 ? N N N 3 ? O N N 3 ? P N N 3 ? Q N N 3 ? R N N 3 ? S N N 3 ? T N N 3 ? U N N 4 ? V N N 3 ? W N N 5 ? # _struct_biol.id 1 # loop_ _struct_conf.conf_type_id _struct_conf.id _struct_conf.pdbx_PDB_helix_id _struct_conf.beg_label_comp_id _struct_conf.beg_label_asym_id _struct_conf.beg_label_seq_id _struct_conf.pdbx_beg_PDB_ins_code _struct_conf.end_label_comp_id _struct_conf.end_label_asym_id _struct_conf.end_label_seq_id _struct_conf.pdbx_end_PDB_ins_code _struct_conf.beg_auth_comp_id _struct_conf.beg_auth_asym_id _struct_conf.beg_auth_seq_id _struct_conf.end_auth_comp_id _struct_conf.end_auth_asym_id _struct_conf.end_auth_seq_id _struct_conf.pdbx_PDB_helix_class _struct_conf.details _struct_conf.pdbx_PDB_helix_length HELX_P HELX_P1 1 ASP A 47 ? ASN A 61 ? ASP A 75 ASN A 89 1 ? 15 HELX_P HELX_P2 2 ILE A 85 ? ASN A 93 ? ILE A 113 ASN A 121 1 ? 9 HELX_P HELX_P3 3 ASP A 120 ? VAL A 135 ? ASP A 148 VAL A 163 1 ? 16 HELX_P HELX_P4 4 THR A 166 ? ASN A 180 ? THR A 194 ASN A 208 1 ? 15 HELX_P HELX_P5 5 PRO A 204 ? ASN A 221 ? PRO A 232 ASN A 249 1 ? 18 HELX_P HELX_P6 6 ASP A 238 ? ASP A 258 ? ASP A 266 ASP A 286 1 ? 21 HELX_P HELX_P7 7 SER A 275 ? PHE A 290 ? SER A 303 PHE A 318 1 ? 16 HELX_P HELX_P8 8 PHE A 290 ? GLY A 295 ? PHE A 318 GLY A 323 1 ? 6 HELX_P HELX_P9 9 ASP A 308 ? MET A 312 ? ASP A 336 MET A 340 1 ? 5 HELX_P HELX_P10 10 ARG A 319 ? VAL A 329 ? ARG A 347 VAL A 357 1 ? 11 HELX_P HELX_P11 11 PRO A 348 ? TYR A 359 ? PRO A 376 TYR A 387 1 ? 12 HELX_P HELX_P12 12 GLY A 390 ? GLN A 393 ? GLY A 418 GLN A 421 5 ? 4 HELX_P HELX_P13 13 HIS A 405 ? ASN A 422 ? HIS A 433 ASN A 450 1 ? 18 HELX_P HELX_P14 14 ASP A 427 ? GLY A 441 ? ASP A 455 GLY A 469 1 ? 15 HELX_P HELX_P15 15 LEU A 443 ? ASN A 452 ? LEU A 471 ASN A 480 1 ? 10 HELX_P HELX_P16 16 ALA A 470 ? SER A 486 ? ALA A 498 SER A 514 1 ? 17 HELX_P HELX_P17 17 ALA A 490 ? LEU A 515 ? ALA A 518 LEU A 543 1 ? 26 HELX_P HELX_P18 18 PRO A 516 ? ASN A 549 ? PRO A 544 ASN A 577 1 ? 34 HELX_P HELX_P19 19 ASP A 551 ? SER A 572 ? ASP A 579 SER A 600 1 ? 22 HELX_P HELX_P20 20 VAL A 580 ? LEU A 589 ? VAL A 608 LEU A 617 1 ? 10 # _struct_conf_type.id HELX_P _struct_conf_type.criteria ? _struct_conf_type.reference ? # loop_ _struct_conn.id _struct_conn.conn_type_id _struct_conn.pdbx_leaving_atom_flag _struct_conn.pdbx_PDB_id _struct_conn.ptnr1_label_asym_id _struct_conn.ptnr1_label_comp_id _struct_conn.ptnr1_label_seq_id _struct_conn.ptnr1_label_atom_id _struct_conn.pdbx_ptnr1_label_alt_id _struct_conn.pdbx_ptnr1_PDB_ins_code _struct_conn.pdbx_ptnr1_standard_comp_id _struct_conn.ptnr1_symmetry _struct_conn.ptnr2_label_asym_id _struct_conn.ptnr2_label_comp_id _struct_conn.ptnr2_label_seq_id _struct_conn.ptnr2_label_atom_id _struct_conn.pdbx_ptnr2_label_alt_id _struct_conn.pdbx_ptnr2_PDB_ins_code _struct_conn.ptnr1_auth_asym_id _struct_conn.ptnr1_auth_comp_id _struct_conn.ptnr1_auth_seq_id _struct_conn.ptnr2_auth_asym_id _struct_conn.ptnr2_auth_comp_id _struct_conn.ptnr2_auth_seq_id _struct_conn.ptnr2_symmetry _struct_conn.pdbx_ptnr3_label_atom_id _struct_conn.pdbx_ptnr3_label_seq_id _struct_conn.pdbx_ptnr3_label_comp_id _struct_conn.pdbx_ptnr3_label_asym_id _struct_conn.pdbx_ptnr3_label_alt_id _struct_conn.pdbx_ptnr3_PDB_ins_code _struct_conn.details _struct_conn.pdbx_dist_value _struct_conn.pdbx_value_order metalc1 metalc ? ? A GLU 23 OE2 ? ? ? 1_555 O CD . CD ? ? A GLU 51 A CD 1632 1_555 ? ? ? ? ? ? ? 1.716 ? metalc2 metalc ? ? C CD . CD ? ? ? 1_555 A GLU 517 OE1 ? ? A CD 1620 A GLU 545 2_545 ? ? ? ? ? ? ? 2.063 ? metalc3 metalc ? ? C CD . CD ? ? ? 1_555 W HOH . O ? ? A CD 1620 A HOH 2025 1_555 ? ? ? ? ? ? ? 2.271 ? metalc4 metalc ? ? C CD . CD ? ? ? 1_555 A ASP 89 OD1 ? ? A CD 1620 A ASP 117 1_555 ? ? ? ? ? ? ? 2.220 ? metalc5 metalc ? ? C CD . CD ? ? ? 1_555 A ASP 89 OD2 ? ? A CD 1620 A ASP 117 1_555 ? ? ? ? ? ? ? 2.988 ? metalc6 metalc ? ? C CD . CD ? ? ? 1_555 A GLU 117 OE2 ? ? A CD 1620 A GLU 145 1_555 ? ? ? ? ? ? ? 2.270 ? metalc7 metalc ? ? C CD . CD ? ? ? 1_555 A GLU 517 OE2 ? ? A CD 1620 A GLU 545 2_545 ? ? ? ? ? ? ? 2.589 ? metalc8 metalc ? ? C CD . CD ? ? ? 1_555 W HOH . O ? ? A CD 1620 A HOH 2022 1_555 ? ? ? ? ? ? ? 2.541 ? metalc9 metalc ? ? D CD . CD ? ? ? 1_555 W HOH . O ? ? A CD 1621 A HOH 2055 6_555 ? ? ? ? ? ? ? 2.036 ? metalc10 metalc ? ? D CD . CD ? ? ? 1_555 A ASP 111 OD2 ? ? A CD 1621 A ASP 139 1_555 ? ? ? ? ? ? ? 2.173 ? metalc11 metalc ? ? D CD . CD ? ? ? 1_555 A ASP 111 OD1 ? ? A CD 1621 A ASP 139 1_555 ? ? ? ? ? ? ? 2.612 ? metalc12 metalc ? ? D CD . CD ? ? ? 1_555 A ASP 240 OD2 ? ? A CD 1621 A ASP 268 6_555 ? ? ? ? ? ? ? 2.148 ? metalc13 metalc ? ? D CD . CD ? ? ? 1_555 W HOH . O ? ? A CD 1621 A HOH 2031 1_555 ? ? ? ? ? ? ? 2.155 ? metalc14 metalc ? ? E CD . CD ? ? ? 1_555 A GLU 254 OE2 ? ? A CD 1622 A GLU 282 1_555 ? ? ? ? ? ? ? 2.083 ? metalc15 metalc ? ? E CD . CD ? ? ? 1_555 A ASP 258 OD2 ? ? A CD 1622 A ASP 286 1_555 ? ? ? ? ? ? ? 2.277 ? metalc16 metalc ? ? E CD . CD ? ? ? 1_555 W HOH . O ? ? A CD 1622 A HOH 2059 1_555 ? ? ? ? ? ? ? 2.284 ? metalc17 metalc ? ? E CD . CD ? ? ? 1_555 A GLU 560 OE1 ? ? A CD 1622 A GLU 588 2_545 ? ? ? ? ? ? ? 2.720 ? metalc18 metalc ? ? E CD . CD ? ? ? 1_555 A GLU 560 OE2 ? ? A CD 1622 A GLU 588 2_545 ? ? ? ? ? ? ? 2.098 ? metalc19 metalc ? ? E CD . CD ? ? ? 1_555 W HOH . O ? ? A CD 1622 A HOH 2101 2_545 ? ? ? ? ? ? ? 2.248 ? metalc20 metalc ? ? E CD . CD ? ? ? 1_555 A ASP 258 OD1 ? ? A CD 1622 A ASP 286 1_555 ? ? ? ? ? ? ? 2.470 ? metalc21 metalc ? ? F CD . CD ? ? ? 1_555 A ASP 30 OD1 ? ? A CD 1623 A ASP 58 1_555 ? ? ? ? ? ? ? 2.851 ? metalc22 metalc ? ? F CD . CD ? ? ? 1_555 A ASP 30 OD2 ? ? A CD 1623 A ASP 58 1_555 ? ? ? ? ? ? ? 2.241 ? metalc23 metalc ? ? F CD . CD ? ? ? 1_555 A GLU 244 OE2 ? ? A CD 1623 A GLU 272 6_555 ? ? ? ? ? ? ? 2.740 ? metalc24 metalc ? ? F CD . CD ? ? ? 1_555 W HOH . O ? ? A CD 1623 A HOH 2007 1_555 ? ? ? ? ? ? ? 2.019 ? metalc25 metalc ? ? F CD . CD ? ? ? 1_555 W HOH . O ? ? A CD 1623 A HOH 2008 1_555 ? ? ? ? ? ? ? 2.040 ? metalc26 metalc ? ? F CD . CD ? ? ? 1_555 A GLU 244 OE1 ? ? A CD 1623 A GLU 272 6_555 ? ? ? ? ? ? ? 2.061 ? metalc27 metalc ? ? G CD . CD ? ? ? 1_555 A GLU 26 OE1 ? ? A CD 1624 A GLU 54 5_554 ? ? ? ? ? ? ? 3.061 ? metalc28 metalc ? ? G CD . CD ? ? ? 1_555 A GLU 26 OE2 ? ? A CD 1624 A GLU 54 5_554 ? ? ? ? ? ? ? 2.741 ? metalc29 metalc ? ? G CD . CD ? ? ? 1_555 A ASP 238 OD2 ? ? A CD 1624 A ASP 266 1_555 ? ? ? ? ? ? ? 2.276 ? metalc30 metalc ? ? H CD . CD ? ? ? 1_555 A GLU 522 OE2 ? ? A CD 1625 A GLU 550 2_545 ? ? ? ? ? ? ? 2.159 ? metalc31 metalc ? ? H CD . CD ? ? ? 1_555 A ASP 84 OD2 ? ? A CD 1625 A ASP 112 1_555 ? ? ? ? ? ? ? 2.254 ? metalc32 metalc ? ? H CD . CD ? ? ? 1_555 W HOH . O ? ? A CD 1625 A HOH 2020 1_555 ? ? ? ? ? ? ? 2.268 ? metalc33 metalc ? ? H CD . CD ? ? ? 1_555 W HOH . O ? ? A CD 1625 A HOH 2097 2_545 ? ? ? ? ? ? ? 2.190 ? metalc34 metalc ? ? H CD . CD ? ? ? 1_555 W HOH . O ? ? A CD 1625 A HOH 2098 2_545 ? ? ? ? ? ? ? 2.199 ? metalc35 metalc ? ? I CD . CD ? ? ? 1_555 A GLU 553 OE1 ? ? A CD 1626 A GLU 581 1_555 ? ? ? ? ? ? ? 2.460 ? metalc36 metalc ? ? I CD . CD ? ? ? 1_555 A GLU 243 OE1 ? ? A CD 1626 A GLU 271 3_654 ? ? ? ? ? ? ? 2.775 ? metalc37 metalc ? ? J CD . CD ? ? ? 1_555 A LEU 40 O ? ? A CD 1627 A LEU 68 1_555 ? ? ? ? ? ? ? 2.393 ? metalc38 metalc ? ? J CD . CD ? ? ? 1_555 A GLU 43 OE1 ? ? A CD 1627 A GLU 71 1_555 ? ? ? ? ? ? ? 2.636 ? metalc39 metalc ? ? J CD . CD ? ? ? 1_555 A GLU 43 OE2 ? ? A CD 1627 A GLU 71 1_555 ? ? ? ? ? ? ? 2.580 ? metalc40 metalc ? ? J CD . CD ? ? ? 1_555 W HOH . O ? ? A CD 1627 A HOH 2012 1_555 ? ? ? ? ? ? ? 2.160 ? metalc41 metalc ? ? J CD . CD ? ? ? 1_555 W HOH . O ? ? A CD 1627 A HOH 2014 1_555 ? ? ? ? ? ? ? 2.401 ? metalc42 metalc ? ? K CD . CD ? ? ? 1_555 A GLU 45 O ? ? A CD 1628 A GLU 73 1_555 ? ? ? ? ? ? ? 2.306 ? metalc43 metalc ? ? K CD . CD ? ? ? 1_555 W HOH . O ? ? A CD 1628 A HOH 2015 1_555 ? ? ? ? ? ? ? 2.399 ? metalc44 metalc ? ? K CD . CD ? ? ? 1_555 A GLU 80 OE1 ? ? A CD 1628 A GLU 108 1_555 ? ? ? ? ? ? ? 2.064 ? metalc45 metalc ? ? K CD . CD ? ? ? 1_555 A ASP 83 OD1 ? ? A CD 1628 A ASP 111 1_555 ? ? ? ? ? ? ? 2.308 ? metalc46 metalc ? ? K CD . CD ? ? ? 1_555 A ASP 83 OD2 ? ? A CD 1628 A ASP 111 1_555 ? ? ? ? ? ? ? 2.827 ? metalc47 metalc ? ? K CD . CD ? ? ? 1_555 W HOH . O ? ? A CD 1628 A HOH 2019 1_555 ? ? ? ? ? ? ? 2.278 ? metalc48 metalc ? ? L CD . CD ? ? ? 1_555 W HOH . O ? ? A CD 1629 A HOH 2032 1_555 ? ? ? ? ? ? ? 3.071 ? metalc49 metalc ? ? L CD . CD ? ? ? 1_555 W HOH . O ? ? A CD 1629 A HOH 2033 1_555 ? ? ? ? ? ? ? 2.806 ? metalc50 metalc ? ? L CD . CD ? ? ? 1_555 A ASP 224 OD1 ? ? A CD 1629 A ASP 252 1_555 ? ? ? ? ? ? ? 2.490 ? metalc51 metalc ? ? M CD . CD ? ? ? 1_555 W HOH . O ? ? A CD 1630 A HOH 2030 1_555 ? ? ? ? ? ? ? 2.251 ? metalc52 metalc ? ? M CD . CD ? ? ? 1_555 A GLU 142 OE2 ? ? A CD 1630 A GLU 170 1_555 ? ? ? ? ? ? ? 2.570 ? metalc53 metalc ? ? M CD . CD ? ? ? 1_555 W HOH . O ? ? A CD 1630 A HOH 2011 1_555 ? ? ? ? ? ? ? 2.135 ? metalc54 metalc ? ? M CD . CD ? ? ? 1_555 W HOH . O ? ? A CD 1630 A HOH 2010 1_555 ? ? ? ? ? ? ? 2.508 ? metalc55 metalc ? ? M CD . CD ? ? ? 1_555 A GLU 142 OE1 ? ? A CD 1630 A GLU 170 1_555 ? ? ? ? ? ? ? 2.370 ? metalc56 metalc ? ? N CD . CD ? ? ? 1_555 A GLU 334 OE1 ? ? A CD 1631 A GLU 362 1_555 ? ? ? ? ? ? ? 2.332 ? metalc57 metalc ? ? N CD . CD ? ? ? 1_555 A GLU 334 OE2 ? ? A CD 1631 A GLU 362 1_555 ? ? ? ? ? ? ? 2.304 ? metalc58 metalc ? ? N CD . CD ? ? ? 1_555 W HOH . O ? ? A CD 1631 A HOH 2081 1_555 ? ? ? ? ? ? ? 2.315 ? metalc59 metalc ? ? N CD . CD ? ? ? 1_555 A ASP 396 OD1 ? ? A CD 1631 A ASP 424 1_555 ? ? ? ? ? ? ? 2.607 ? metalc60 metalc ? ? N CD . CD ? ? ? 1_555 A ASP 396 OD2 ? ? A CD 1631 A ASP 424 1_555 ? ? ? ? ? ? ? 2.354 ? metalc61 metalc ? ? N CD . CD ? ? ? 1_555 W HOH . O ? ? A CD 1631 A HOH 2073 1_555 ? ? ? ? ? ? ? 2.580 ? metalc62 metalc ? ? O CD . CD ? ? ? 1_555 A ASP 424 OD1 ? ? A CD 1632 A ASP 452 1_555 ? ? ? ? ? ? ? 2.105 ? metalc63 metalc ? ? O CD . CD ? ? ? 1_555 W HOH . O ? ? A CD 1632 A HOH 2086 1_555 ? ? ? ? ? ? ? 2.419 ? metalc64 metalc ? ? O CD . CD ? ? ? 1_555 A GLU 23 OE1 ? ? A CD 1632 A GLU 51 1_555 ? ? ? ? ? ? ? 2.709 ? metalc65 metalc ? ? O CD . CD ? ? ? 1_555 A ASN 422 OD1 ? ? A CD 1632 A ASN 450 1_555 ? ? ? ? ? ? ? 2.487 ? metalc66 metalc ? ? P CD . CD ? ? ? 1_555 A GLU 506 OE1 ? ? A CD 1633 A GLU 534 1_555 ? ? ? ? ? ? ? 2.551 ? metalc67 metalc ? ? P CD . CD ? ? ? 1_555 A ASP 446 OD2 ? ? A CD 1633 A ASP 474 1_555 ? ? ? ? ? ? ? 2.380 ? metalc68 metalc ? ? P CD . CD ? ? ? 1_555 A GLU 506 OE2 ? ? A CD 1633 A GLU 534 1_555 ? ? ? ? ? ? ? 2.861 ? metalc69 metalc ? ? P CD . CD ? ? ? 1_555 A ASP 446 OD1 ? ? A CD 1633 A ASP 474 1_555 ? ? ? ? ? ? ? 2.575 ? metalc70 metalc ? ? Q CD . CD ? ? ? 1_555 A HIS 248 NE2 ? ? A CD 1634 A HIS 276 1_555 ? ? ? ? ? ? ? 2.507 ? metalc71 metalc ? ? Q CD . CD ? ? ? 1_555 A GLU 244 OE2 ? ? A CD 1634 A GLU 272 1_555 ? ? ? ? ? ? ? 2.112 ? metalc72 metalc ? ? R CD . CD ? ? ? 1_555 A HIS 385 NE2 ? ? A CD 1635 A HIS 413 1_555 ? ? ? ? ? ? ? 2.248 ? metalc73 metalc ? ? S CD . CD ? ? ? 1_555 A LYS 376 O ? ? A CD 1636 A LYS 404 1_555 ? ? ? ? ? ? ? 2.509 ? metalc74 metalc ? ? S CD . CD ? ? ? 1_555 W HOH . O ? ? A CD 1636 A HOH 2075 1_555 ? ? ? ? ? ? ? 2.737 ? metalc75 metalc ? ? S CD . CD ? ? ? 1_555 A HIS 405 NE2 ? ? A CD 1636 A HIS 433 1_555 ? ? ? ? ? ? ? 2.631 ? metalc76 metalc ? ? T CD . CD ? ? ? 1_555 A GLU 521 OE2 ? ? A CD 1637 A GLU 549 2_545 ? ? ? ? ? ? ? 2.503 ? metalc77 metalc ? ? T CD . CD ? ? ? 1_555 A ASP 89 OD2 ? ? A CD 1637 A ASP 117 1_555 ? ? ? ? ? ? ? 3.216 ? metalc78 metalc ? ? T CD . CD ? ? ? 1_555 A GLU 517 OE2 ? ? A CD 1637 A GLU 545 2_545 ? ? ? ? ? ? ? 2.897 ? metalc79 metalc ? ? T CD . CD ? ? ? 1_555 A GLU 521 OE1 ? ? A CD 1637 A GLU 549 2_545 ? ? ? ? ? ? ? 2.701 ? covale1 covale ? ? B SER 4 OG ? ? ? 1_555 U NAG . C1 ? ? T SER 405 T NAG 500 1_555 ? ? ? ? ? ? ? 1.438 ? metalc80 metalc ? ? V CD . CD ? ? ? 1_555 B HIS 3 NE2 ? ? T CD 1409 T HIS 404 1_555 ? ? ? ? ? ? ? 2.281 ? # loop_ _struct_conn_type.id _struct_conn_type.criteria _struct_conn_type.reference metalc ? ? covale ? ? # loop_ _struct_mon_prot_cis.pdbx_id _struct_mon_prot_cis.label_comp_id _struct_mon_prot_cis.label_seq_id _struct_mon_prot_cis.label_asym_id _struct_mon_prot_cis.label_alt_id _struct_mon_prot_cis.pdbx_PDB_ins_code _struct_mon_prot_cis.auth_comp_id _struct_mon_prot_cis.auth_seq_id _struct_mon_prot_cis.auth_asym_id _struct_mon_prot_cis.pdbx_label_comp_id_2 _struct_mon_prot_cis.pdbx_label_seq_id_2 _struct_mon_prot_cis.pdbx_label_asym_id_2 _struct_mon_prot_cis.pdbx_PDB_ins_code_2 _struct_mon_prot_cis.pdbx_auth_comp_id_2 _struct_mon_prot_cis.pdbx_auth_seq_id_2 _struct_mon_prot_cis.pdbx_auth_asym_id_2 _struct_mon_prot_cis.pdbx_PDB_model_num _struct_mon_prot_cis.pdbx_omega_angle 1 ASN 19 A . ? ASN 47 A PRO 20 A ? PRO 48 A 1 -2.86 2 TYR 369 A . ? TYR 397 A PRO 370 A ? PRO 398 A 1 8.43 # loop_ _struct_sheet.id _struct_sheet.type _struct_sheet.number_strands _struct_sheet.details AA ? 7 ? AB ? 2 ? AC ? 9 ? AD ? 2 ? AE ? 2 ? # loop_ _struct_sheet_order.sheet_id _struct_sheet_order.range_id_1 _struct_sheet_order.range_id_2 _struct_sheet_order.offset _struct_sheet_order.sense AA 1 2 ? anti-parallel AA 2 3 ? anti-parallel AA 3 4 ? anti-parallel AA 4 5 ? parallel AA 5 6 ? parallel AA 6 7 ? parallel AB 1 2 ? anti-parallel AC 1 2 ? parallel AC 2 3 ? parallel AC 3 4 ? parallel AC 4 5 ? parallel AC 5 6 ? parallel AC 6 7 ? parallel AC 7 8 ? parallel AC 8 9 ? parallel AD 1 2 ? anti-parallel AE 1 2 ? anti-parallel # loop_ _struct_sheet_range.sheet_id _struct_sheet_range.id _struct_sheet_range.beg_label_comp_id _struct_sheet_range.beg_label_asym_id _struct_sheet_range.beg_label_seq_id _struct_sheet_range.pdbx_beg_PDB_ins_code _struct_sheet_range.end_label_comp_id _struct_sheet_range.end_label_asym_id _struct_sheet_range.end_label_seq_id _struct_sheet_range.pdbx_end_PDB_ins_code _struct_sheet_range.beg_auth_comp_id _struct_sheet_range.beg_auth_asym_id _struct_sheet_range.beg_auth_seq_id _struct_sheet_range.end_auth_comp_id _struct_sheet_range.end_auth_asym_id _struct_sheet_range.end_auth_seq_id AA 1 ASN A 24 ? VAL A 27 ? ASN A 52 VAL A 55 AA 2 VAL A 143 ? ASP A 147 ? VAL A 171 ASP A 175 AA 3 TYR A 105 ? ASN A 110 ? TYR A 133 ASN A 138 AA 4 LYS A 113 ? GLY A 118 ? LYS A 141 GLY A 146 AA 5 THR A 75 ? GLU A 80 ? THR A 103 GLU A 108 AA 6 SER A 37 ? VAL A 41 ? SER A 65 VAL A 69 AA 7 GLU A 64 ? ILE A 65 ? GLU A 92 ILE A 93 AB 1 PHE A 32 ? LYS A 33 ? PHE A 60 LYS A 61 AB 2 ASN A 139 ? ILE A 140 ? ASN A 167 ILE A 168 AC 1 ALA A 153 ? GLU A 158 ? ALA A 181 GLU A 186 AC 2 VAL A 395 ? VAL A 400 ? VAL A 423 VAL A 428 AC 3 MET A 363 ? TRP A 367 ? MET A 391 TRP A 395 AC 4 GLU A 334 ? TRP A 337 ? GLU A 362 TRP A 365 AC 5 ILE A 301 ? VAL A 303 ? ILE A 329 VAL A 331 AC 6 SER A 263 ? TYR A 267 ? SER A 291 TYR A 295 AC 7 ASP A 224 ? ILE A 229 ? ASP A 252 ILE A 257 AC 8 THR A 184 ? TYR A 187 ? THR A 212 TYR A 215 AC 9 ALA A 153 ? GLU A 158 ? ALA A 181 GLU A 186 AD 1 VAL A 313 ? SER A 314 ? VAL A 341 SER A 342 AD 2 GLN A 317 ? PRO A 318 ? GLN A 345 PRO A 346 AE 1 MET A 457 ? ASP A 458 ? MET A 485 ASP A 486 AE 2 LYS A 464 ? SER A 465 ? LYS A 492 SER A 493 # loop_ _pdbx_struct_sheet_hbond.sheet_id _pdbx_struct_sheet_hbond.range_id_1 _pdbx_struct_sheet_hbond.range_id_2 _pdbx_struct_sheet_hbond.range_1_label_atom_id _pdbx_struct_sheet_hbond.range_1_label_comp_id _pdbx_struct_sheet_hbond.range_1_label_asym_id _pdbx_struct_sheet_hbond.range_1_label_seq_id _pdbx_struct_sheet_hbond.range_1_PDB_ins_code _pdbx_struct_sheet_hbond.range_1_auth_atom_id _pdbx_struct_sheet_hbond.range_1_auth_comp_id _pdbx_struct_sheet_hbond.range_1_auth_asym_id _pdbx_struct_sheet_hbond.range_1_auth_seq_id _pdbx_struct_sheet_hbond.range_2_label_atom_id _pdbx_struct_sheet_hbond.range_2_label_comp_id _pdbx_struct_sheet_hbond.range_2_label_asym_id _pdbx_struct_sheet_hbond.range_2_label_seq_id _pdbx_struct_sheet_hbond.range_2_PDB_ins_code _pdbx_struct_sheet_hbond.range_2_auth_atom_id _pdbx_struct_sheet_hbond.range_2_auth_comp_id _pdbx_struct_sheet_hbond.range_2_auth_asym_id _pdbx_struct_sheet_hbond.range_2_auth_seq_id AA 1 2 N GLU A 26 ? N GLU A 54 O ASN A 144 ? O ASN A 172 AA 2 3 N ASP A 147 ? N ASP A 175 O TYR A 105 ? O TYR A 133 AA 3 4 N ASN A 110 ? N ASN A 138 O LYS A 113 ? O LYS A 141 AA 4 5 N ILE A 114 ? N ILE A 142 O THR A 75 ? O THR A 103 AA 5 6 N LEU A 76 ? N LEU A 104 O ASN A 39 ? O ASN A 67 AA 6 7 N ILE A 38 ? N ILE A 66 O GLU A 64 ? O GLU A 92 AB 1 2 N PHE A 32 ? N PHE A 60 O ILE A 140 ? O ILE A 168 AC 1 2 N ALA A 153 ? N ALA A 181 O ASP A 396 ? O ASP A 424 AC 2 3 N ASP A 396 ? N ASP A 424 O MET A 363 ? O MET A 391 AC 3 4 N ALA A 364 ? N ALA A 392 O VAL A 335 ? O VAL A 363 AC 4 5 N MET A 336 ? N MET A 364 O THR A 302 ? O THR A 330 AC 5 6 N ILE A 301 ? N ILE A 329 O PHE A 264 ? O PHE A 292 AC 6 7 N SER A 263 ? N SER A 291 O PHE A 225 ? O PHE A 253 AC 7 8 N VAL A 226 ? N VAL A 254 O TYR A 185 ? O TYR A 213 AC 8 9 N THR A 184 ? N THR A 212 O ARG A 154 ? O ARG A 182 AD 1 2 N SER A 314 ? N SER A 342 O GLN A 317 ? O GLN A 345 AE 1 2 N MET A 457 ? N MET A 485 O SER A 465 ? O SER A 493 # loop_ _struct_site.id _struct_site.pdbx_evidence_code _struct_site.pdbx_auth_asym_id _struct_site.pdbx_auth_comp_id _struct_site.pdbx_auth_seq_id _struct_site.pdbx_auth_ins_code _struct_site.pdbx_num_residues _struct_site.details AC1 Software ? ? ? ? 5 'BINDING SITE FOR RESIDUE CD A 1620' AC2 Software ? ? ? ? 4 'BINDING SITE FOR RESIDUE CD A 1621' AC3 Software ? ? ? ? 5 'BINDING SITE FOR RESIDUE CD A 1622' AC4 Software ? ? ? ? 4 'BINDING SITE FOR RESIDUE CD A 1623' AC5 Software ? ? ? ? 3 'BINDING SITE FOR RESIDUE CD A 1624' AC6 Software ? ? ? ? 5 'BINDING SITE FOR RESIDUE CD A 1625' AC7 Software ? ? ? ? 3 'BINDING SITE FOR RESIDUE CD A 1626' AC8 Software ? ? ? ? 4 'BINDING SITE FOR RESIDUE CD A 1627' AC9 Software ? ? ? ? 5 'BINDING SITE FOR RESIDUE CD A 1628' BC1 Software ? ? ? ? 4 'BINDING SITE FOR RESIDUE CD A 1629' BC2 Software ? ? ? ? 4 'BINDING SITE FOR RESIDUE CD A 1630' BC3 Software ? ? ? ? 4 'BINDING SITE FOR RESIDUE CD A 1631' BC4 Software ? ? ? ? 4 'BINDING SITE FOR RESIDUE CD A 1632' BC5 Software ? ? ? ? 3 'BINDING SITE FOR RESIDUE CD A 1633' BC6 Software ? ? ? ? 2 'BINDING SITE FOR RESIDUE CD A 1634' BC7 Software ? ? ? ? 1 'BINDING SITE FOR RESIDUE CD A 1635' BC8 Software ? ? ? ? 3 'BINDING SITE FOR RESIDUE CD A 1636' BC9 Software ? ? ? ? 3 'BINDING SITE FOR RESIDUE CD A 1637' CC1 Software ? ? ? ? 1 'BINDING SITE FOR RESIDUE CD T 1409' CC2 Software ? ? ? ? 14 'BINDING SITE FOR MONO-SACCHARIDE NAG T 500 BOUND TO SER T 405' # loop_ _struct_site_gen.id _struct_site_gen.site_id _struct_site_gen.pdbx_num_res _struct_site_gen.label_comp_id _struct_site_gen.label_asym_id _struct_site_gen.label_seq_id _struct_site_gen.pdbx_auth_ins_code _struct_site_gen.auth_comp_id _struct_site_gen.auth_asym_id _struct_site_gen.auth_seq_id _struct_site_gen.label_atom_id _struct_site_gen.label_alt_id _struct_site_gen.symmetry _struct_site_gen.details 1 AC1 5 ASP A 89 ? ASP A 117 . ? 1_555 ? 2 AC1 5 GLU A 117 ? GLU A 145 . ? 1_555 ? 3 AC1 5 GLU A 517 ? GLU A 545 . ? 2_545 ? 4 AC1 5 HOH W . ? HOH A 2022 . ? 1_555 ? 5 AC1 5 HOH W . ? HOH A 2025 . ? 1_555 ? 6 AC2 4 ASP A 111 ? ASP A 139 . ? 1_555 ? 7 AC2 4 ASP A 240 ? ASP A 268 . ? 6_555 ? 8 AC2 4 HOH W . ? HOH A 2031 . ? 1_555 ? 9 AC2 4 HOH W . ? HOH A 2055 . ? 6_555 ? 10 AC3 5 GLU A 254 ? GLU A 282 . ? 1_555 ? 11 AC3 5 ASP A 258 ? ASP A 286 . ? 1_555 ? 12 AC3 5 GLU A 560 ? GLU A 588 . ? 2_545 ? 13 AC3 5 HOH W . ? HOH A 2059 . ? 1_555 ? 14 AC3 5 HOH W . ? HOH A 2101 . ? 2_545 ? 15 AC4 4 ASP A 30 ? ASP A 58 . ? 1_555 ? 16 AC4 4 GLU A 244 ? GLU A 272 . ? 6_555 ? 17 AC4 4 HOH W . ? HOH A 2007 . ? 1_555 ? 18 AC4 4 HOH W . ? HOH A 2008 . ? 1_555 ? 19 AC5 3 GLU A 26 ? GLU A 54 . ? 5_554 ? 20 AC5 3 ASP A 238 ? ASP A 266 . ? 1_555 ? 21 AC5 3 LYS A 278 ? LYS A 306 . ? 1_555 ? 22 AC6 5 ASP A 84 ? ASP A 112 . ? 1_555 ? 23 AC6 5 GLU A 522 ? GLU A 550 . ? 2_545 ? 24 AC6 5 HOH W . ? HOH A 2020 . ? 1_555 ? 25 AC6 5 HOH W . ? HOH A 2097 . ? 2_545 ? 26 AC6 5 HOH W . ? HOH A 2098 . ? 2_545 ? 27 AC7 3 GLU A 243 ? GLU A 271 . ? 3_654 ? 28 AC7 3 ARG A 285 ? ARG A 313 . ? 3_654 ? 29 AC7 3 GLU A 553 ? GLU A 581 . ? 1_555 ? 30 AC8 4 LEU A 40 ? LEU A 68 . ? 1_555 ? 31 AC8 4 GLU A 43 ? GLU A 71 . ? 1_555 ? 32 AC8 4 HOH W . ? HOH A 2012 . ? 1_555 ? 33 AC8 4 HOH W . ? HOH A 2014 . ? 1_555 ? 34 AC9 5 GLU A 45 ? GLU A 73 . ? 1_555 ? 35 AC9 5 GLU A 80 ? GLU A 108 . ? 1_555 ? 36 AC9 5 ASP A 83 ? ASP A 111 . ? 1_555 ? 37 AC9 5 HOH W . ? HOH A 2015 . ? 1_555 ? 38 AC9 5 HOH W . ? HOH A 2019 . ? 1_555 ? 39 BC1 4 ASP A 122 ? ASP A 150 . ? 1_555 ? 40 BC1 4 ASP A 224 ? ASP A 252 . ? 1_555 ? 41 BC1 4 HOH W . ? HOH A 2032 . ? 1_555 ? 42 BC1 4 HOH W . ? HOH A 2033 . ? 1_555 ? 43 BC2 4 GLU A 142 ? GLU A 170 . ? 1_555 ? 44 BC2 4 HOH W . ? HOH A 2010 . ? 1_555 ? 45 BC2 4 HOH W . ? HOH A 2011 . ? 1_555 ? 46 BC2 4 HOH W . ? HOH A 2030 . ? 1_555 ? 47 BC3 4 GLU A 334 ? GLU A 362 . ? 1_555 ? 48 BC3 4 ASP A 396 ? ASP A 424 . ? 1_555 ? 49 BC3 4 HOH W . ? HOH A 2073 . ? 1_555 ? 50 BC3 4 HOH W . ? HOH A 2081 . ? 1_555 ? 51 BC4 4 GLU A 23 ? GLU A 51 . ? 1_555 ? 52 BC4 4 ASN A 422 ? ASN A 450 . ? 1_555 ? 53 BC4 4 ASP A 424 ? ASP A 452 . ? 1_555 ? 54 BC4 4 HOH W . ? HOH A 2086 . ? 1_555 ? 55 BC5 3 ASP A 446 ? ASP A 474 . ? 1_555 ? 56 BC5 3 ARG A 503 ? ARG A 531 . ? 1_555 ? 57 BC5 3 GLU A 506 ? GLU A 534 . ? 1_555 ? 58 BC6 2 GLU A 244 ? GLU A 272 . ? 1_555 ? 59 BC6 2 HIS A 248 ? HIS A 276 . ? 1_555 ? 60 BC7 1 HIS A 385 ? HIS A 413 . ? 1_555 ? 61 BC8 3 LYS A 376 ? LYS A 404 . ? 1_555 ? 62 BC8 3 HIS A 405 ? HIS A 433 . ? 1_555 ? 63 BC8 3 HOH W . ? HOH A 2075 . ? 1_555 ? 64 BC9 3 ASP A 89 ? ASP A 117 . ? 1_555 ? 65 BC9 3 GLU A 517 ? GLU A 545 . ? 2_545 ? 66 BC9 3 GLU A 521 ? GLU A 549 . ? 2_545 ? 67 CC1 1 HIS B 3 ? HIS T 404 . ? 1_555 ? 68 CC2 14 GLY A 159 ? GLY A 187 . ? 1_555 ? 69 CC2 14 PHE A 160 ? PHE A 188 . ? 1_555 ? 70 CC2 14 TYR A 161 ? TYR A 189 . ? 1_555 ? 71 CC2 14 LYS A 190 ? LYS A 218 . ? 1_555 ? 72 CC2 14 ASP A 269 ? ASP A 297 . ? 1_555 ? 73 CC2 14 ASN A 270 ? ASN A 298 . ? 1_555 ? 74 CC2 14 TYR A 307 ? TYR A 335 . ? 1_555 ? 75 CC2 14 THR A 338 ? THR A 366 . ? 1_555 ? 76 CC2 14 VAL A 342 ? VAL A 370 . ? 1_555 ? 77 CC2 14 TRP A 366 ? TRP A 394 . ? 1_555 ? 78 CC2 14 ASN A 368 ? ASN A 396 . ? 1_555 ? 79 CC2 14 ASP A 373 ? ASP A 401 . ? 1_555 ? 80 CC2 14 ASN A 401 ? ASN A 429 . ? 1_555 ? 81 CC2 14 SER B 4 ? SER T 405 . ? 1_555 ? # _database_PDB_matrix.entry_id 2YDQ _database_PDB_matrix.origx[1][1] 1.000000 _database_PDB_matrix.origx[1][2] 0.000000 _database_PDB_matrix.origx[1][3] 0.000000 _database_PDB_matrix.origx[2][1] 0.000000 _database_PDB_matrix.origx[2][2] 1.000000 _database_PDB_matrix.origx[2][3] 0.000000 _database_PDB_matrix.origx[3][1] 0.000000 _database_PDB_matrix.origx[3][2] 0.000000 _database_PDB_matrix.origx[3][3] 1.000000 _database_PDB_matrix.origx_vector[1] 0.00000 _database_PDB_matrix.origx_vector[2] 0.00000 _database_PDB_matrix.origx_vector[3] 0.00000 # _atom_sites.entry_id 2YDQ _atom_sites.fract_transf_matrix[1][1] 0.008460 _atom_sites.fract_transf_matrix[1][2] 0.004884 _atom_sites.fract_transf_matrix[1][3] 0.000000 _atom_sites.fract_transf_matrix[2][1] 0.000000 _atom_sites.fract_transf_matrix[2][2] 0.009768 _atom_sites.fract_transf_matrix[2][3] 0.000000 _atom_sites.fract_transf_matrix[3][1] 0.000000 _atom_sites.fract_transf_matrix[3][2] 0.000000 _atom_sites.fract_transf_matrix[3][3] 0.006747 _atom_sites.fract_transf_vector[1] 0.00000 _atom_sites.fract_transf_vector[2] 0.00000 _atom_sites.fract_transf_vector[3] 0.00000 # loop_ _atom_type.symbol C CD N O S # loop_ _atom_site.group_PDB _atom_site.id _atom_site.type_symbol _atom_site.label_atom_id _atom_site.label_alt_id _atom_site.label_comp_id _atom_site.label_asym_id _atom_site.label_entity_id _atom_site.label_seq_id _atom_site.pdbx_PDB_ins_code _atom_site.Cartn_x _atom_site.Cartn_y _atom_site.Cartn_z _atom_site.occupancy _atom_site.B_iso_or_equiv _atom_site.pdbx_formal_charge _atom_site.auth_seq_id _atom_site.auth_comp_id _atom_site.auth_asym_id _atom_site.auth_atom_id _atom_site.pdbx_PDB_model_num ATOM 1 N N . GLN A 1 12 ? 71.927 -10.692 13.349 1.00 30.38 ? 40 GLN A N 1 ATOM 2 C CA . GLN A 1 12 ? 70.482 -10.875 13.705 1.00 31.56 ? 40 GLN A CA 1 ATOM 3 C C . GLN A 1 12 ? 69.609 -11.570 12.610 1.00 31.17 ? 40 GLN A C 1 ATOM 4 O O . GLN A 1 12 ? 69.498 -11.077 11.484 1.00 31.27 ? 40 GLN A O 1 ATOM 5 C CB . GLN A 1 12 ? 69.873 -9.526 14.090 1.00 32.01 ? 40 GLN A CB 1 ATOM 6 C CG . GLN A 1 12 ? 68.506 -9.604 14.791 1.00 34.55 ? 40 GLN A CG 1 ATOM 7 C CD . GLN A 1 12 ? 68.104 -8.247 15.383 1.00 39.19 ? 40 GLN A CD 1 ATOM 8 O OE1 . GLN A 1 12 ? 67.743 -7.319 14.642 1.00 41.44 ? 40 GLN A OE1 1 ATOM 9 N NE2 . GLN A 1 12 ? 68.186 -8.119 16.718 1.00 38.34 ? 40 GLN A NE2 1 ATOM 10 N N . VAL A 1 13 ? 68.978 -12.701 12.949 1.00 30.37 ? 41 VAL A N 1 ATOM 11 C CA . VAL A 1 13 ? 68.332 -13.539 11.929 1.00 29.69 ? 41 VAL A CA 1 ATOM 12 C C . VAL A 1 13 ? 66.812 -13.556 12.050 1.00 29.32 ? 41 VAL A C 1 ATOM 13 O O . VAL A 1 13 ? 66.258 -13.740 13.139 1.00 28.99 ? 41 VAL A O 1 ATOM 14 C CB . VAL A 1 13 ? 68.914 -15.011 11.839 1.00 29.56 ? 41 VAL A CB 1 ATOM 15 C CG1 . VAL A 1 13 ? 70.285 -15.127 12.489 1.00 29.79 ? 41 VAL A CG1 1 ATOM 16 C CG2 . VAL A 1 13 ? 68.020 -15.970 12.462 1.00 29.83 ? 41 VAL A CG2 1 ATOM 17 N N . LEU A 1 14 ? 66.149 -13.386 10.912 1.00 28.55 ? 42 LEU A N 1 ATOM 18 C CA . LEU A 1 14 ? 64.697 -13.283 10.893 1.00 28.09 ? 42 LEU A CA 1 ATOM 19 C C . LEU A 1 14 ? 63.988 -14.633 10.821 1.00 27.07 ? 42 LEU A C 1 ATOM 20 O O . LEU A 1 14 ? 64.509 -15.597 10.281 1.00 26.96 ? 42 LEU A O 1 ATOM 21 C CB . LEU A 1 14 ? 64.246 -12.379 9.743 1.00 28.57 ? 42 LEU A CB 1 ATOM 22 C CG . LEU A 1 14 ? 64.832 -10.963 9.856 1.00 29.79 ? 42 LEU A CG 1 ATOM 23 C CD1 . LEU A 1 14 ? 64.750 -10.249 8.524 1.00 30.53 ? 42 LEU A CD1 1 ATOM 24 C CD2 . LEU A 1 14 ? 64.146 -10.157 10.969 1.00 31.21 ? 42 LEU A CD2 1 ATOM 25 N N . VAL A 1 15 ? 62.789 -14.682 11.384 1.00 26.05 ? 43 VAL A N 1 ATOM 26 C CA . VAL A 1 15 ? 61.951 -15.855 11.274 1.00 25.24 ? 43 VAL A CA 1 ATOM 27 C C . VAL A 1 15 ? 61.508 -15.965 9.806 1.00 24.63 ? 43 VAL A C 1 ATOM 28 O O . VAL A 1 15 ? 60.841 -15.065 9.288 1.00 24.08 ? 43 VAL A O 1 ATOM 29 C CB . VAL A 1 15 ? 60.715 -15.757 12.201 1.00 25.20 ? 43 VAL A CB 1 ATOM 30 C CG1 . VAL A 1 15 ? 59.893 -17.023 12.117 1.00 25.95 ? 43 VAL A CG1 1 ATOM 31 C CG2 . VAL A 1 15 ? 61.124 -15.502 13.632 1.00 24.07 ? 43 VAL A CG2 1 ATOM 32 N N . PRO A 1 16 ? 61.889 -17.060 9.123 1.00 24.16 ? 44 PRO A N 1 ATOM 33 C CA . PRO A 1 16 ? 61.522 -17.202 7.709 1.00 23.78 ? 44 PRO A CA 1 ATOM 34 C C . PRO A 1 16 ? 60.036 -17.502 7.542 1.00 23.50 ? 44 PRO A C 1 ATOM 35 O O . PRO A 1 16 ? 59.317 -17.680 8.548 1.00 23.51 ? 44 PRO A O 1 ATOM 36 C CB . PRO A 1 16 ? 62.352 -18.410 7.237 1.00 23.34 ? 44 PRO A CB 1 ATOM 37 C CG . PRO A 1 16 ? 63.322 -18.680 8.309 1.00 24.20 ? 44 PRO A CG 1 ATOM 38 C CD . PRO A 1 16 ? 62.699 -18.195 9.588 1.00 24.11 ? 44 PRO A CD 1 ATOM 39 N N . ASN A 1 17 ? 59.565 -17.545 6.293 1.00 22.85 ? 45 ASN A N 1 ATOM 40 C CA . ASN A 1 17 ? 58.217 -18.070 6.015 1.00 22.25 ? 45 ASN A CA 1 ATOM 41 C C . ASN A 1 17 ? 58.041 -19.455 6.663 1.00 21.03 ? 45 ASN A C 1 ATOM 42 O O . ASN A 1 17 ? 58.858 -20.352 6.453 1.00 20.65 ? 45 ASN A O 1 ATOM 43 C CB . ASN A 1 17 ? 57.953 -18.164 4.498 1.00 22.68 ? 45 ASN A CB 1 ATOM 44 C CG . ASN A 1 17 ? 57.552 -16.831 3.870 1.00 23.87 ? 45 ASN A CG 1 ATOM 45 O OD1 . ASN A 1 17 ? 56.914 -15.982 4.507 1.00 25.14 ? 45 ASN A OD1 1 ATOM 46 N ND2 . ASN A 1 17 ? 57.913 -16.654 2.600 1.00 24.88 ? 45 ASN A ND2 1 ATOM 47 N N . LEU A 1 18 ? 56.999 -19.604 7.472 1.00 19.92 ? 46 LEU A N 1 ATOM 48 C CA . LEU A 1 18 ? 56.648 -20.876 8.081 1.00 18.80 ? 46 LEU A CA 1 ATOM 49 C C . LEU A 1 18 ? 55.301 -21.368 7.589 1.00 18.63 ? 46 LEU A C 1 ATOM 50 O O . LEU A 1 18 ? 54.371 -20.577 7.357 1.00 18.60 ? 46 LEU A O 1 ATOM 51 C CB . LEU A 1 18 ? 56.586 -20.731 9.603 1.00 18.67 ? 46 LEU A CB 1 ATOM 52 C CG . LEU A 1 18 ? 57.900 -20.404 10.317 1.00 18.46 ? 46 LEU A CG 1 ATOM 53 C CD1 . LEU A 1 18 ? 57.625 -20.051 11.754 1.00 18.66 ? 46 LEU A CD1 1 ATOM 54 C CD2 . LEU A 1 18 ? 58.913 -21.529 10.232 1.00 16.32 ? 46 LEU A CD2 1 ATOM 55 N N . ASN A 1 19 ? 55.165 -22.682 7.457 1.00 18.44 ? 47 ASN A N 1 ATOM 56 C CA . ASN A 1 19 ? 53.860 -23.256 7.132 1.00 18.06 ? 47 ASN A CA 1 ATOM 57 C C . ASN A 1 19 ? 53.695 -24.648 7.681 1.00 18.23 ? 47 ASN A C 1 ATOM 58 O O . ASN A 1 19 ? 54.512 -25.511 7.389 1.00 18.24 ? 47 ASN A O 1 ATOM 59 C CB . ASN A 1 19 ? 53.610 -23.288 5.628 1.00 17.87 ? 47 ASN A CB 1 ATOM 60 C CG . ASN A 1 19 ? 52.165 -23.550 5.302 1.00 17.56 ? 47 ASN A CG 1 ATOM 61 O OD1 . ASN A 1 19 ? 51.282 -22.899 5.840 1.00 18.77 ? 47 ASN A OD1 1 ATOM 62 N ND2 . ASN A 1 19 ? 51.910 -24.505 4.423 1.00 17.13 ? 47 ASN A ND2 1 ATOM 63 N N . PRO A 1 20 ? 52.623 -24.881 8.462 1.00 18.47 ? 48 PRO A N 1 ATOM 64 C CA . PRO A 1 20 ? 51.606 -23.913 8.899 1.00 18.33 ? 48 PRO A CA 1 ATOM 65 C C . PRO A 1 20 ? 52.154 -22.883 9.880 1.00 18.47 ? 48 PRO A C 1 ATOM 66 O O . PRO A 1 20 ? 53.297 -23.025 10.353 1.00 18.35 ? 48 PRO A O 1 ATOM 67 C CB . PRO A 1 20 ? 50.584 -24.785 9.615 1.00 18.25 ? 48 PRO A CB 1 ATOM 68 C CG . PRO A 1 20 ? 50.815 -26.146 9.092 1.00 18.57 ? 48 PRO A CG 1 ATOM 69 C CD . PRO A 1 20 ? 52.270 -26.250 8.859 1.00 18.13 ? 48 PRO A CD 1 ATOM 70 N N . THR A 1 21 ? 51.351 -21.852 10.166 1.00 18.11 ? 49 THR A N 1 ATOM 71 C CA . THR A 1 21 ? 51.709 -20.827 11.142 1.00 17.87 ? 49 THR A CA 1 ATOM 72 C C . THR A 1 21 ? 51.663 -21.453 12.527 1.00 18.09 ? 49 THR A C 1 ATOM 73 O O . THR A 1 21 ? 50.610 -21.887 12.960 1.00 17.94 ? 49 THR A O 1 ATOM 74 C CB . THR A 1 21 ? 50.708 -19.628 11.115 1.00 18.36 ? 49 THR A CB 1 ATOM 75 O OG1 . THR A 1 21 ? 50.442 -19.221 9.765 1.00 16.75 ? 49 THR A OG1 1 ATOM 76 C CG2 . THR A 1 21 ? 51.241 -18.431 11.931 1.00 16.69 ? 49 THR A CG2 1 ATOM 77 N N . PRO A 1 22 ? 52.796 -21.494 13.240 1.00 18.88 ? 50 PRO A N 1 ATOM 78 C CA . PRO A 1 22 ? 52.752 -22.084 14.584 1.00 19.73 ? 50 PRO A CA 1 ATOM 79 C C . PRO A 1 22 ? 51.883 -21.238 15.500 1.00 20.43 ? 50 PRO A C 1 ATOM 80 O O . PRO A 1 22 ? 51.865 -20.015 15.347 1.00 20.79 ? 50 PRO A O 1 ATOM 81 C CB . PRO A 1 22 ? 54.205 -22.024 15.039 1.00 19.04 ? 50 PRO A CB 1 ATOM 82 C CG . PRO A 1 22 ? 54.986 -21.851 13.790 1.00 19.74 ? 50 PRO A CG 1 ATOM 83 C CD . PRO A 1 22 ? 54.136 -20.991 12.928 1.00 18.85 ? 50 PRO A CD 1 ATOM 84 N N . GLU A 1 23 ? 51.168 -21.862 16.428 1.00 21.35 ? 51 GLU A N 1 ATOM 85 C CA . GLU A 1 23 ? 50.270 -21.101 17.297 1.00 23.37 ? 51 GLU A CA 1 ATOM 86 C C . GLU A 1 23 ? 50.997 -20.021 18.122 1.00 23.58 ? 51 GLU A C 1 ATOM 87 O O . GLU A 1 23 ? 50.628 -18.846 18.062 1.00 23.84 ? 51 GLU A O 1 ATOM 88 C CB . GLU A 1 23 ? 49.452 -22.013 18.202 1.00 23.65 ? 51 GLU A CB 1 ATOM 89 C CG . GLU A 1 23 ? 48.099 -21.412 18.571 1.00 27.85 ? 51 GLU A CG 1 ATOM 90 C CD . GLU A 1 23 ? 47.196 -21.277 17.366 1.00 30.67 ? 51 GLU A CD 1 ATOM 91 O OE1 . GLU A 1 23 ? 46.871 -22.307 16.726 1.00 32.56 ? 51 GLU A OE1 1 ATOM 92 O OE2 . GLU A 1 23 ? 46.825 -20.130 17.041 1.00 33.68 ? 51 GLU A OE2 1 ATOM 93 N N . ASN A 1 24 ? 52.035 -20.411 18.856 1.00 23.79 ? 52 ASN A N 1 ATOM 94 C CA . ASN A 1 24 ? 52.766 -19.485 19.722 1.00 24.31 ? 52 ASN A CA 1 ATOM 95 C C . ASN A 1 24 ? 54.228 -19.436 19.355 1.00 24.84 ? 52 ASN A C 1 ATOM 96 O O . ASN A 1 24 ? 54.934 -20.444 19.466 1.00 25.42 ? 52 ASN A O 1 ATOM 97 C CB . ASN A 1 24 ? 52.633 -19.886 21.205 1.00 23.87 ? 52 ASN A CB 1 ATOM 98 C CG . ASN A 1 24 ? 51.188 -20.155 21.616 1.00 25.00 ? 52 ASN A CG 1 ATOM 99 O OD1 . ASN A 1 24 ? 50.316 -19.287 21.493 1.00 26.45 ? 52 ASN A OD1 1 ATOM 100 N ND2 . ASN A 1 24 ? 50.921 -21.370 22.087 1.00 23.89 ? 52 ASN A ND2 1 ATOM 101 N N . LEU A 1 25 ? 54.687 -18.264 18.930 1.00 25.25 ? 53 LEU A N 1 ATOM 102 C CA . LEU A 1 25 ? 56.089 -18.066 18.640 1.00 25.88 ? 53 LEU A CA 1 ATOM 103 C C . LEU A 1 25 ? 56.573 -16.727 19.179 1.00 26.68 ? 53 LEU A C 1 ATOM 104 O O . LEU A 1 25 ? 55.976 -15.677 18.892 1.00 26.93 ? 53 LEU A O 1 ATOM 105 C CB . LEU A 1 25 ? 56.312 -18.129 17.127 1.00 25.63 ? 53 LEU A CB 1 ATOM 106 C CG . LEU A 1 25 ? 57.762 -18.055 16.627 1.00 26.01 ? 53 LEU A CG 1 ATOM 107 C CD1 . LEU A 1 25 ? 57.919 -18.701 15.249 1.00 24.35 ? 53 LEU A CD1 1 ATOM 108 C CD2 . LEU A 1 25 ? 58.267 -16.605 16.626 1.00 25.58 ? 53 LEU A CD2 1 ATOM 109 N N . GLU A 1 26 ? 57.658 -16.756 19.941 1.00 27.02 ? 54 GLU A N 1 ATOM 110 C CA . GLU A 1 26 ? 58.342 -15.522 20.306 1.00 28.35 ? 54 GLU A CA 1 ATOM 111 C C . GLU A 1 26 ? 59.806 -15.572 19.959 1.00 27.37 ? 54 GLU A C 1 ATOM 112 O O . GLU A 1 26 ? 60.448 -16.590 20.138 1.00 27.69 ? 54 GLU A O 1 ATOM 113 C CB . GLU A 1 26 ? 58.238 -15.253 21.793 1.00 29.24 ? 54 GLU A CB 1 ATOM 114 C CG . GLU A 1 26 ? 56.899 -14.769 22.260 1.00 35.38 ? 54 GLU A CG 1 ATOM 115 C CD . GLU A 1 26 ? 56.746 -14.990 23.752 1.00 45.12 ? 54 GLU A CD 1 ATOM 116 O OE1 . GLU A 1 26 ? 57.777 -15.302 24.424 1.00 46.31 ? 54 GLU A OE1 1 ATOM 117 O OE2 . GLU A 1 26 ? 55.590 -14.859 24.242 1.00 50.05 ? 54 GLU A OE2 1 ATOM 118 N N . VAL A 1 27 ? 60.340 -14.459 19.478 1.00 26.72 ? 55 VAL A N 1 ATOM 119 C CA . VAL A 1 27 ? 61.772 -14.316 19.290 1.00 25.52 ? 55 VAL A CA 1 ATOM 120 C C . VAL A 1 27 ? 62.367 -13.958 20.648 1.00 25.32 ? 55 VAL A C 1 ATOM 121 O O . VAL A 1 27 ? 61.917 -13.025 21.314 1.00 25.70 ? 55 VAL A O 1 ATOM 122 C CB . VAL A 1 27 ? 62.080 -13.238 18.228 1.00 25.61 ? 55 VAL A CB 1 ATOM 123 C CG1 . VAL A 1 27 ? 63.578 -13.152 17.938 1.00 24.75 ? 55 VAL A CG1 1 ATOM 124 C CG2 . VAL A 1 27 ? 61.298 -13.527 16.951 1.00 24.42 ? 55 VAL A CG2 1 ATOM 125 N N . VAL A 1 28 ? 63.346 -14.734 21.080 1.00 24.67 ? 56 VAL A N 1 ATOM 126 C CA . VAL A 1 28 ? 63.948 -14.545 22.392 1.00 24.40 ? 56 VAL A CA 1 ATOM 127 C C . VAL A 1 28 ? 65.426 -14.160 22.306 1.00 24.80 ? 56 VAL A C 1 ATOM 128 O O . VAL A 1 28 ? 66.056 -13.955 23.332 1.00 25.12 ? 56 VAL A O 1 ATOM 129 C CB . VAL A 1 28 ? 63.772 -15.800 23.325 1.00 24.36 ? 56 VAL A CB 1 ATOM 130 C CG1 . VAL A 1 28 ? 62.311 -16.166 23.474 1.00 23.34 ? 56 VAL A CG1 1 ATOM 131 C CG2 . VAL A 1 28 ? 64.562 -16.997 22.799 1.00 23.37 ? 56 VAL A CG2 1 ATOM 132 N N . GLY A 1 29 ? 65.965 -14.053 21.090 1.00 25.29 ? 57 GLY A N 1 ATOM 133 C CA . GLY A 1 29 ? 67.363 -13.701 20.889 1.00 25.87 ? 57 GLY A CA 1 ATOM 134 C C . GLY A 1 29 ? 67.663 -13.287 19.458 1.00 26.66 ? 57 GLY A C 1 ATOM 135 O O . GLY A 1 29 ? 66.774 -13.259 18.619 1.00 27.68 ? 57 GLY A O 1 ATOM 136 N N . ASP A 1 30 ? 68.926 -12.970 19.186 1.00 27.21 ? 58 ASP A N 1 ATOM 137 C CA . ASP A 1 30 ? 69.382 -12.553 17.865 1.00 28.03 ? 58 ASP A CA 1 ATOM 138 C C . ASP A 1 30 ? 69.409 -13.652 16.816 1.00 28.17 ? 58 ASP A C 1 ATOM 139 O O . ASP A 1 30 ? 69.499 -13.342 15.620 1.00 28.67 ? 58 ASP A O 1 ATOM 140 C CB . ASP A 1 30 ? 70.814 -11.981 17.933 1.00 28.59 ? 58 ASP A CB 1 ATOM 141 C CG . ASP A 1 30 ? 70.874 -10.587 18.554 1.00 30.36 ? 58 ASP A CG 1 ATOM 142 O OD1 . ASP A 1 30 ? 69.850 -9.861 18.563 1.00 32.10 ? 58 ASP A OD1 1 ATOM 143 O OD2 . ASP A 1 30 ? 71.960 -10.214 19.047 1.00 31.58 ? 58 ASP A OD2 1 ATOM 144 N N . GLY A 1 31 ? 69.397 -14.916 17.245 1.00 27.63 ? 59 GLY A N 1 ATOM 145 C CA . GLY A 1 31 ? 69.724 -16.019 16.351 1.00 27.31 ? 59 GLY A CA 1 ATOM 146 C C . GLY A 1 31 ? 71.175 -16.437 16.503 1.00 27.69 ? 59 GLY A C 1 ATOM 147 O O . GLY A 1 31 ? 71.961 -15.728 17.138 1.00 27.57 ? 59 GLY A O 1 ATOM 148 N N . PHE A 1 32 ? 71.524 -17.605 15.961 1.00 27.81 ? 60 PHE A N 1 ATOM 149 C CA . PHE A 1 32 ? 72.914 -18.042 15.898 1.00 28.62 ? 60 PHE A CA 1 ATOM 150 C C . PHE A 1 32 ? 73.125 -18.932 14.684 1.00 29.57 ? 60 PHE A C 1 ATOM 151 O O . PHE A 1 32 ? 72.160 -19.390 14.078 1.00 29.74 ? 60 PHE A O 1 ATOM 152 C CB . PHE A 1 32 ? 73.350 -18.768 17.180 1.00 28.20 ? 60 PHE A CB 1 ATOM 153 C CG . PHE A 1 32 ? 72.513 -19.971 17.525 1.00 27.69 ? 60 PHE A CG 1 ATOM 154 C CD1 . PHE A 1 32 ? 72.836 -21.220 17.040 1.00 26.45 ? 60 PHE A CD1 1 ATOM 155 C CD2 . PHE A 1 32 ? 71.408 -19.856 18.361 1.00 27.40 ? 60 PHE A CD2 1 ATOM 156 C CE1 . PHE A 1 32 ? 72.071 -22.324 17.364 1.00 25.03 ? 60 PHE A CE1 1 ATOM 157 C CE2 . PHE A 1 32 ? 70.653 -20.964 18.684 1.00 24.96 ? 60 PHE A CE2 1 ATOM 158 C CZ . PHE A 1 32 ? 70.992 -22.197 18.180 1.00 24.26 ? 60 PHE A CZ 1 ATOM 159 N N . LYS A 1 33 ? 74.386 -19.150 14.324 1.00 30.48 ? 61 LYS A N 1 ATOM 160 C CA . LYS A 1 33 ? 74.727 -20.104 13.284 1.00 31.73 ? 61 LYS A CA 1 ATOM 161 C C . LYS A 1 33 ? 74.983 -21.464 13.926 1.00 31.77 ? 61 LYS A C 1 ATOM 162 O O . LYS A 1 33 ? 75.714 -21.576 14.924 1.00 31.74 ? 61 LYS A O 1 ATOM 163 C CB . LYS A 1 33 ? 75.947 -19.638 12.471 1.00 32.30 ? 61 LYS A CB 1 ATOM 164 C CG . LYS A 1 33 ? 76.545 -20.719 11.577 1.00 34.72 ? 61 LYS A CG 1 ATOM 165 C CD . LYS A 1 33 ? 77.549 -20.149 10.585 1.00 39.41 ? 61 LYS A CD 1 ATOM 166 C CE . LYS A 1 33 ? 76.851 -19.625 9.332 1.00 42.68 ? 61 LYS A CE 1 ATOM 167 N NZ . LYS A 1 33 ? 77.726 -18.714 8.524 1.00 45.25 ? 61 LYS A NZ 1 ATOM 168 N N . ILE A 1 34 ? 74.343 -22.482 13.358 1.00 31.77 ? 62 ILE A N 1 ATOM 169 C CA . ILE A 1 34 ? 74.560 -23.860 13.750 1.00 31.59 ? 62 ILE A CA 1 ATOM 170 C C . ILE A 1 34 ? 75.924 -24.289 13.223 1.00 32.04 ? 62 ILE A C 1 ATOM 171 O O . ILE A 1 34 ? 76.224 -24.128 12.034 1.00 32.03 ? 62 ILE A O 1 ATOM 172 C CB . ILE A 1 34 ? 73.466 -24.773 13.177 1.00 31.06 ? 62 ILE A CB 1 ATOM 173 C CG1 . ILE A 1 34 ? 72.108 -24.393 13.750 1.00 30.32 ? 62 ILE A CG1 1 ATOM 174 C CG2 . ILE A 1 34 ? 73.733 -26.182 13.540 1.00 31.11 ? 62 ILE A CG2 1 ATOM 175 C CD1 . ILE A 1 34 ? 70.936 -25.097 13.114 1.00 28.71 ? 62 ILE A CD1 1 ATOM 176 N N . THR A 1 35 ? 76.753 -24.829 14.110 1.00 32.81 ? 63 THR A N 1 ATOM 177 C CA . THR A 1 35 ? 78.102 -25.268 13.729 1.00 33.44 ? 63 THR A CA 1 ATOM 178 C C . THR A 1 35 ? 78.063 -26.355 12.661 1.00 34.08 ? 63 THR A C 1 ATOM 179 O O . THR A 1 35 ? 76.998 -26.870 12.333 1.00 34.51 ? 63 THR A O 1 ATOM 180 C CB . THR A 1 35 ? 78.901 -25.739 14.941 1.00 33.69 ? 63 THR A CB 1 ATOM 181 O OG1 . THR A 1 35 ? 78.090 -26.625 15.728 1.00 32.23 ? 63 THR A OG1 1 ATOM 182 C CG2 . THR A 1 35 ? 79.340 -24.514 15.778 1.00 33.53 ? 63 THR A CG2 1 ATOM 183 N N . SER A 1 36 ? 79.214 -26.695 12.091 1.00 34.76 ? 64 SER A N 1 ATOM 184 C CA . SER A 1 36 ? 79.213 -27.628 10.964 1.00 35.29 ? 64 SER A CA 1 ATOM 185 C C . SER A 1 36 ? 79.051 -29.080 11.431 1.00 35.25 ? 64 SER A C 1 ATOM 186 O O . SER A 1 36 ? 78.906 -30.002 10.613 1.00 35.49 ? 64 SER A O 1 ATOM 187 C CB . SER A 1 36 ? 80.451 -27.435 10.085 1.00 35.41 ? 64 SER A CB 1 ATOM 188 O OG . SER A 1 36 ? 81.629 -27.673 10.834 1.00 36.77 ? 64 SER A OG 1 ATOM 189 N N . SER A 1 37 ? 79.025 -29.257 12.748 1.00 34.84 ? 65 SER A N 1 ATOM 190 C CA . SER A 1 37 ? 78.895 -30.559 13.356 1.00 34.98 ? 65 SER A CA 1 ATOM 191 C C . SER A 1 37 ? 78.089 -30.356 14.642 1.00 34.48 ? 65 SER A C 1 ATOM 192 O O . SER A 1 37 ? 78.336 -29.392 15.357 1.00 35.34 ? 65 SER A O 1 ATOM 193 C CB . SER A 1 37 ? 80.297 -31.104 13.641 1.00 35.39 ? 65 SER A CB 1 ATOM 194 O OG . SER A 1 37 ? 80.266 -32.499 13.861 1.00 37.79 ? 65 SER A OG 1 ATOM 195 N N . ILE A 1 38 ? 77.111 -31.217 14.932 1.00 33.43 ? 66 ILE A N 1 ATOM 196 C CA . ILE A 1 38 ? 76.238 -30.979 16.090 1.00 32.17 ? 66 ILE A CA 1 ATOM 197 C C . ILE A 1 38 ? 76.228 -32.129 17.103 1.00 31.93 ? 66 ILE A C 1 ATOM 198 O O . ILE A 1 38 ? 76.522 -33.279 16.757 1.00 32.32 ? 66 ILE A O 1 ATOM 199 C CB . ILE A 1 38 ? 74.792 -30.591 15.646 1.00 32.44 ? 66 ILE A CB 1 ATOM 200 C CG1 . ILE A 1 38 ? 74.171 -31.647 14.736 1.00 31.29 ? 66 ILE A CG1 1 ATOM 201 C CG2 . ILE A 1 38 ? 74.791 -29.282 14.895 1.00 31.42 ? 66 ILE A CG2 1 ATOM 202 C CD1 . ILE A 1 38 ? 73.097 -32.427 15.386 1.00 30.35 ? 66 ILE A CD1 1 ATOM 203 N N . ASN A 1 39 ? 75.930 -31.836 18.360 1.00 30.93 ? 67 ASN A N 1 ATOM 204 C CA . ASN A 1 39 ? 75.707 -32.912 19.302 1.00 30.89 ? 67 ASN A CA 1 ATOM 205 C C . ASN A 1 39 ? 74.248 -33.289 19.196 1.00 30.58 ? 67 ASN A C 1 ATOM 206 O O . ASN A 1 39 ? 73.369 -32.431 19.320 1.00 31.25 ? 67 ASN A O 1 ATOM 207 C CB . ASN A 1 39 ? 76.025 -32.494 20.744 1.00 31.36 ? 67 ASN A CB 1 ATOM 208 C CG . ASN A 1 39 ? 77.388 -31.848 20.883 1.00 33.09 ? 67 ASN A CG 1 ATOM 209 O OD1 . ASN A 1 39 ? 78.392 -32.360 20.372 1.00 34.41 ? 67 ASN A OD1 1 ATOM 210 N ND2 . ASN A 1 39 ? 77.431 -30.702 21.568 1.00 33.33 ? 67 ASN A ND2 1 ATOM 211 N N . LEU A 1 40 ? 73.971 -34.561 18.948 1.00 29.57 ? 68 LEU A N 1 ATOM 212 C CA . LEU A 1 40 ? 72.600 -35.005 18.863 1.00 28.45 ? 68 LEU A CA 1 ATOM 213 C C . LEU A 1 40 ? 72.275 -35.768 20.122 1.00 28.38 ? 68 LEU A C 1 ATOM 214 O O . LEU A 1 40 ? 72.996 -36.706 20.474 1.00 29.09 ? 68 LEU A O 1 ATOM 215 C CB . LEU A 1 40 ? 72.392 -35.892 17.644 1.00 28.24 ? 68 LEU A CB 1 ATOM 216 C CG . LEU A 1 40 ? 70.947 -36.320 17.423 1.00 27.27 ? 68 LEU A CG 1 ATOM 217 C CD1 . LEU A 1 40 ? 70.082 -35.073 17.313 1.00 24.60 ? 68 LEU A CD1 1 ATOM 218 C CD2 . LEU A 1 40 ? 70.860 -37.171 16.179 1.00 26.46 ? 68 LEU A CD2 1 ATOM 219 N N . VAL A 1 41 ? 71.188 -35.390 20.793 1.00 27.41 ? 69 VAL A N 1 ATOM 220 C CA . VAL A 1 41 ? 70.864 -35.981 22.096 1.00 26.67 ? 69 VAL A CA 1 ATOM 221 C C . VAL A 1 41 ? 69.422 -36.449 22.183 1.00 26.81 ? 69 VAL A C 1 ATOM 222 O O . VAL A 1 41 ? 68.501 -35.735 21.806 1.00 26.49 ? 69 VAL A O 1 ATOM 223 C CB . VAL A 1 41 ? 71.207 -35.029 23.286 1.00 26.38 ? 69 VAL A CB 1 ATOM 224 C CG1 . VAL A 1 41 ? 70.694 -35.602 24.613 1.00 25.21 ? 69 VAL A CG1 1 ATOM 225 C CG2 . VAL A 1 41 ? 72.723 -34.778 23.357 1.00 25.37 ? 69 VAL A CG2 1 ATOM 226 N N . GLY A 1 42 ? 69.250 -37.673 22.665 1.00 27.35 ? 70 GLY A N 1 ATOM 227 C CA . GLY A 1 42 ? 67.937 -38.247 22.888 1.00 28.23 ? 70 GLY A CA 1 ATOM 228 C C . GLY A 1 42 ? 67.368 -39.060 21.749 1.00 29.33 ? 70 GLY A C 1 ATOM 229 O O . GLY A 1 42 ? 66.235 -39.525 21.856 1.00 29.21 ? 70 GLY A O 1 ATOM 230 N N . GLU A 1 43 ? 68.146 -39.253 20.677 1.00 30.55 ? 71 GLU A N 1 ATOM 231 C CA . GLU A 1 43 ? 67.676 -39.950 19.466 1.00 32.32 ? 71 GLU A CA 1 ATOM 232 C C . GLU A 1 43 ? 67.463 -41.472 19.573 1.00 32.99 ? 71 GLU A C 1 ATOM 233 O O . GLU A 1 43 ? 66.852 -42.063 18.692 1.00 33.44 ? 71 GLU A O 1 ATOM 234 C CB . GLU A 1 43 ? 68.592 -39.654 18.280 1.00 32.37 ? 71 GLU A CB 1 ATOM 235 C CG . GLU A 1 43 ? 69.857 -40.473 18.262 1.00 35.32 ? 71 GLU A CG 1 ATOM 236 C CD . GLU A 1 43 ? 70.970 -39.897 19.138 1.00 39.04 ? 71 GLU A CD 1 ATOM 237 O OE1 . GLU A 1 43 ? 70.681 -39.054 20.021 1.00 38.69 ? 71 GLU A OE1 1 ATOM 238 O OE2 . GLU A 1 43 ? 72.147 -40.296 18.937 1.00 40.54 ? 71 GLU A OE2 1 ATOM 239 N N . GLU A 1 44 ? 67.971 -42.105 20.622 1.00 34.04 ? 72 GLU A N 1 ATOM 240 C CA . GLU A 1 44 ? 67.728 -43.532 20.820 1.00 35.35 ? 72 GLU A CA 1 ATOM 241 C C . GLU A 1 44 ? 66.286 -43.742 21.275 1.00 34.73 ? 72 GLU A C 1 ATOM 242 O O . GLU A 1 44 ? 65.669 -44.742 20.924 1.00 34.99 ? 72 GLU A O 1 ATOM 243 C CB . GLU A 1 44 ? 68.734 -44.176 21.810 1.00 36.30 ? 72 GLU A CB 1 ATOM 244 C CG . GLU A 1 44 ? 70.253 -44.065 21.432 1.00 40.46 ? 72 GLU A CG 1 ATOM 245 C CD . GLU A 1 44 ? 70.960 -42.785 21.981 1.00 46.60 ? 72 GLU A CD 1 ATOM 246 O OE1 . GLU A 1 44 ? 70.305 -41.961 22.682 1.00 47.58 ? 72 GLU A OE1 1 ATOM 247 O OE2 . GLU A 1 44 ? 72.179 -42.598 21.700 1.00 49.04 ? 72 GLU A OE2 1 ATOM 248 N N . GLU A 1 45 ? 65.741 -42.770 22.011 1.00 34.24 ? 73 GLU A N 1 ATOM 249 C CA . GLU A 1 45 ? 64.382 -42.867 22.573 1.00 33.62 ? 73 GLU A CA 1 ATOM 250 C C . GLU A 1 45 ? 63.335 -42.072 21.790 1.00 31.51 ? 73 GLU A C 1 ATOM 251 O O . GLU A 1 45 ? 62.134 -42.299 21.943 1.00 30.65 ? 73 GLU A O 1 ATOM 252 C CB . GLU A 1 45 ? 64.362 -42.436 24.068 1.00 34.89 ? 73 GLU A CB 1 ATOM 253 C CG . GLU A 1 45 ? 65.440 -43.082 25.000 1.00 40.00 ? 73 GLU A CG 1 ATOM 254 C CD . GLU A 1 45 ? 65.457 -44.648 24.992 1.00 47.72 ? 73 GLU A CD 1 ATOM 255 O OE1 . GLU A 1 45 ? 64.711 -45.308 24.206 1.00 50.19 ? 73 GLU A OE1 1 ATOM 256 O OE2 . GLU A 1 45 ? 66.245 -45.224 25.786 1.00 50.19 ? 73 GLU A OE2 1 ATOM 257 N N . ALA A 1 46 ? 63.797 -41.123 20.978 1.00 30.00 ? 74 ALA A N 1 ATOM 258 C CA . ALA A 1 46 ? 62.904 -40.226 20.253 1.00 28.87 ? 74 ALA A CA 1 ATOM 259 C C . ALA A 1 46 ? 62.275 -40.967 19.086 1.00 28.70 ? 74 ALA A C 1 ATOM 260 O O . ALA A 1 46 ? 62.818 -41.983 18.622 1.00 28.08 ? 74 ALA A O 1 ATOM 261 C CB . ALA A 1 46 ? 63.642 -39.016 19.772 1.00 28.27 ? 74 ALA A CB 1 ATOM 262 N N . ASP A 1 47 ? 61.131 -40.459 18.626 1.00 28.40 ? 75 ASP A N 1 ATOM 263 C CA . ASP A 1 47 ? 60.398 -41.045 17.505 1.00 28.31 ? 75 ASP A CA 1 ATOM 264 C C . ASP A 1 47 ? 61.293 -41.312 16.291 1.00 28.14 ? 75 ASP A C 1 ATOM 265 O O . ASP A 1 47 ? 61.924 -40.383 15.778 1.00 27.85 ? 75 ASP A O 1 ATOM 266 C CB . ASP A 1 47 ? 59.263 -40.120 17.101 1.00 28.38 ? 75 ASP A CB 1 ATOM 267 C CG . ASP A 1 47 ? 58.335 -40.757 16.099 1.00 28.65 ? 75 ASP A CG 1 ATOM 268 O OD1 . ASP A 1 47 ? 57.454 -41.526 16.542 1.00 28.12 ? 75 ASP A OD1 1 ATOM 269 O OD2 . ASP A 1 47 ? 58.513 -40.502 14.885 1.00 27.73 ? 75 ASP A OD2 1 ATOM 270 N N . GLU A 1 48 ? 61.343 -42.583 15.871 1.00 28.18 ? 76 GLU A N 1 ATOM 271 C CA . GLU A 1 48 ? 62.156 -43.090 14.738 1.00 28.75 ? 76 GLU A CA 1 ATOM 272 C C . GLU A 1 48 ? 61.958 -42.261 13.432 1.00 27.26 ? 76 GLU A C 1 ATOM 273 O O . GLU A 1 48 ? 62.917 -41.982 12.722 1.00 27.30 ? 76 GLU A O 1 ATOM 274 C CB . GLU A 1 48 ? 61.862 -44.613 14.513 1.00 29.88 ? 76 GLU A CB 1 ATOM 275 C CG . GLU A 1 48 ? 62.950 -45.459 13.726 1.00 35.68 ? 76 GLU A CG 1 ATOM 276 C CD . GLU A 1 48 ? 62.493 -46.908 13.312 1.00 43.48 ? 76 GLU A CD 1 ATOM 277 O OE1 . GLU A 1 48 ? 62.514 -47.862 14.147 1.00 45.78 ? 76 GLU A OE1 1 ATOM 278 O OE2 . GLU A 1 48 ? 62.142 -47.105 12.119 1.00 46.62 ? 76 GLU A OE2 1 ATOM 279 N N . ASN A 1 49 ? 60.726 -41.839 13.142 1.00 25.54 ? 77 ASN A N 1 ATOM 280 C CA . ASN A 1 49 ? 60.424 -41.040 11.931 1.00 24.23 ? 77 ASN A CA 1 ATOM 281 C C . ASN A 1 49 ? 60.866 -39.571 12.006 1.00 23.33 ? 77 ASN A C 1 ATOM 282 O O . ASN A 1 49 ? 61.338 -38.998 11.019 1.00 23.04 ? 77 ASN A O 1 ATOM 283 C CB . ASN A 1 49 ? 58.925 -41.144 11.544 1.00 24.02 ? 77 ASN A CB 1 ATOM 284 C CG . ASN A 1 49 ? 58.445 -42.605 11.406 1.00 24.11 ? 77 ASN A CG 1 ATOM 285 O OD1 . ASN A 1 49 ? 57.538 -43.042 12.114 1.00 24.54 ? 77 ASN A OD1 1 ATOM 286 N ND2 . ASN A 1 49 ? 59.073 -43.357 10.513 1.00 23.94 ? 77 ASN A ND2 1 ATOM 287 N N . ALA A 1 50 ? 60.686 -38.969 13.176 1.00 22.22 ? 78 ALA A N 1 ATOM 288 C CA . ALA A 1 50 ? 61.230 -37.657 13.469 1.00 21.32 ? 78 ALA A CA 1 ATOM 289 C C . ALA A 1 50 ? 62.739 -37.626 13.286 1.00 21.08 ? 78 ALA A C 1 ATOM 290 O O . ALA A 1 50 ? 63.262 -36.739 12.588 1.00 21.23 ? 78 ALA A O 1 ATOM 291 C CB . ALA A 1 50 ? 60.868 -37.240 14.873 1.00 21.31 ? 78 ALA A CB 1 ATOM 292 N N . VAL A 1 51 ? 63.433 -38.596 13.886 1.00 20.63 ? 79 VAL A N 1 ATOM 293 C CA . VAL A 1 51 ? 64.892 -38.648 13.824 1.00 20.66 ? 79 VAL A CA 1 ATOM 294 C C . VAL A 1 51 ? 65.390 -38.830 12.392 1.00 21.32 ? 79 VAL A C 1 ATOM 295 O O . VAL A 1 51 ? 66.336 -38.141 11.988 1.00 20.34 ? 79 VAL A O 1 ATOM 296 C CB . VAL A 1 51 ? 65.506 -39.719 14.779 1.00 20.79 ? 79 VAL A CB 1 ATOM 297 C CG1 . VAL A 1 51 ? 66.988 -39.901 14.504 1.00 18.58 ? 79 VAL A CG1 1 ATOM 298 C CG2 . VAL A 1 51 ? 65.290 -39.319 16.242 1.00 20.43 ? 79 VAL A CG2 1 ATOM 299 N N . ASN A 1 52 ? 64.743 -39.733 11.634 1.00 22.50 ? 80 ASN A N 1 ATOM 300 C CA . ASN A 1 52 ? 65.049 -39.917 10.202 1.00 23.97 ? 80 ASN A CA 1 ATOM 301 C C . ASN A 1 52 ? 64.865 -38.639 9.388 1.00 23.80 ? 80 ASN A C 1 ATOM 302 O O . ASN A 1 52 ? 65.746 -38.283 8.589 1.00 24.03 ? 80 ASN A O 1 ATOM 303 C CB . ASN A 1 52 ? 64.263 -41.067 9.568 1.00 24.75 ? 80 ASN A CB 1 ATOM 304 C CG . ASN A 1 52 ? 64.784 -42.454 10.002 1.00 29.05 ? 80 ASN A CG 1 ATOM 305 O OD1 . ASN A 1 52 ? 65.845 -42.587 10.643 1.00 32.74 ? 80 ASN A OD1 1 ATOM 306 N ND2 . ASN A 1 52 ? 64.022 -43.491 9.664 1.00 30.70 ? 80 ASN A ND2 1 ATOM 307 N N . ALA A 1 53 ? 63.753 -37.933 9.612 1.00 23.16 ? 81 ALA A N 1 ATOM 308 C CA . ALA A 1 53 ? 63.535 -36.637 8.969 1.00 22.98 ? 81 ALA A CA 1 ATOM 309 C C . ALA A 1 53 ? 64.683 -35.678 9.313 1.00 23.22 ? 81 ALA A C 1 ATOM 310 O O . ALA A 1 53 ? 65.235 -35.013 8.434 1.00 23.64 ? 81 ALA A O 1 ATOM 311 C CB . ALA A 1 53 ? 62.199 -36.048 9.380 1.00 22.47 ? 81 ALA A CB 1 ATOM 312 N N . LEU A 1 54 ? 65.050 -35.634 10.590 1.00 23.23 ? 82 LEU A N 1 ATOM 313 C CA . LEU A 1 54 ? 66.140 -34.786 11.054 1.00 23.35 ? 82 LEU A CA 1 ATOM 314 C C . LEU A 1 54 ? 67.477 -35.177 10.426 1.00 23.62 ? 82 LEU A C 1 ATOM 315 O O . LEU A 1 54 ? 68.229 -34.308 9.998 1.00 23.05 ? 82 LEU A O 1 ATOM 316 C CB . LEU A 1 54 ? 66.214 -34.807 12.585 1.00 22.82 ? 82 LEU A CB 1 ATOM 317 C CG . LEU A 1 54 ? 67.329 -34.010 13.267 1.00 22.41 ? 82 LEU A CG 1 ATOM 318 C CD1 . LEU A 1 54 ? 67.313 -32.541 12.863 1.00 20.78 ? 82 LEU A CD1 1 ATOM 319 C CD2 . LEU A 1 54 ? 67.233 -34.183 14.782 1.00 21.49 ? 82 LEU A CD2 1 ATOM 320 N N . ARG A 1 55 ? 67.752 -36.482 10.359 1.00 24.88 ? 83 ARG A N 1 ATOM 321 C CA . ARG A 1 55 ? 68.981 -37.000 9.725 1.00 25.97 ? 83 ARG A CA 1 ATOM 322 C C . ARG A 1 55 ? 69.098 -36.606 8.260 1.00 27.09 ? 83 ARG A C 1 ATOM 323 O O . ARG A 1 55 ? 70.146 -36.098 7.859 1.00 27.84 ? 83 ARG A O 1 ATOM 324 C CB . ARG A 1 55 ? 69.123 -38.514 9.878 1.00 25.42 ? 83 ARG A CB 1 ATOM 325 C CG . ARG A 1 55 ? 69.407 -38.981 11.300 1.00 25.48 ? 83 ARG A CG 1 ATOM 326 C CD . ARG A 1 55 ? 69.748 -40.494 11.331 1.00 26.15 ? 83 ARG A CD 1 ATOM 327 N NE . ARG A 1 55 ? 69.690 -41.059 12.683 1.00 26.79 ? 83 ARG A NE 1 ATOM 328 C CZ . ARG A 1 55 ? 70.688 -41.027 13.572 1.00 28.35 ? 83 ARG A CZ 1 ATOM 329 N NH1 . ARG A 1 55 ? 71.855 -40.462 13.254 1.00 29.08 ? 83 ARG A NH1 1 ATOM 330 N NH2 . ARG A 1 55 ? 70.520 -41.553 14.786 1.00 26.06 ? 83 ARG A NH2 1 ATOM 331 N N . GLU A 1 56 ? 68.036 -36.822 7.471 1.00 28.50 ? 84 GLU A N 1 ATOM 332 C CA . GLU A 1 56 ? 68.023 -36.430 6.040 1.00 30.12 ? 84 GLU A CA 1 ATOM 333 C C . GLU A 1 56 ? 68.322 -34.948 5.850 1.00 29.39 ? 84 GLU A C 1 ATOM 334 O O . GLU A 1 56 ? 69.141 -34.581 5.003 1.00 29.74 ? 84 GLU A O 1 ATOM 335 C CB . GLU A 1 56 ? 66.704 -36.781 5.330 1.00 30.63 ? 84 GLU A CB 1 ATOM 336 C CG . GLU A 1 56 ? 66.369 -38.306 5.263 1.00 37.37 ? 84 GLU A CG 1 ATOM 337 C CD . GLU A 1 56 ? 64.902 -38.607 4.791 1.00 45.34 ? 84 GLU A CD 1 ATOM 338 O OE1 . GLU A 1 56 ? 64.200 -37.656 4.297 1.00 47.45 ? 84 GLU A OE1 1 ATOM 339 O OE2 . GLU A 1 56 ? 64.465 -39.795 4.918 1.00 46.62 ? 84 GLU A OE2 1 ATOM 340 N N . PHE A 1 57 ? 67.673 -34.106 6.650 1.00 28.68 ? 85 PHE A N 1 ATOM 341 C CA . PHE A 1 57 ? 67.892 -32.669 6.581 1.00 28.09 ? 85 PHE A CA 1 ATOM 342 C C . PHE A 1 57 ? 69.342 -32.294 6.877 1.00 27.87 ? 85 PHE A C 1 ATOM 343 O O . PHE A 1 57 ? 69.941 -31.494 6.156 1.00 27.23 ? 85 PHE A O 1 ATOM 344 C CB . PHE A 1 57 ? 66.952 -31.940 7.533 1.00 27.84 ? 85 PHE A CB 1 ATOM 345 C CG . PHE A 1 57 ? 67.117 -30.455 7.512 1.00 27.02 ? 85 PHE A CG 1 ATOM 346 C CD1 . PHE A 1 57 ? 66.559 -29.695 6.475 1.00 27.00 ? 85 PHE A CD1 1 ATOM 347 C CD2 . PHE A 1 57 ? 67.835 -29.815 8.521 1.00 24.60 ? 85 PHE A CD2 1 ATOM 348 C CE1 . PHE A 1 57 ? 66.712 -28.311 6.441 1.00 25.76 ? 85 PHE A CE1 1 ATOM 349 C CE2 . PHE A 1 57 ? 67.998 -28.452 8.502 1.00 25.59 ? 85 PHE A CE2 1 ATOM 350 C CZ . PHE A 1 57 ? 67.444 -27.689 7.457 1.00 25.73 ? 85 PHE A CZ 1 ATOM 351 N N . LEU A 1 58 ? 69.893 -32.881 7.935 1.00 27.70 ? 86 LEU A N 1 ATOM 352 C CA . LEU A 1 58 ? 71.263 -32.606 8.323 1.00 28.23 ? 86 LEU A CA 1 ATOM 353 C C . LEU A 1 58 ? 72.237 -33.019 7.223 1.00 29.24 ? 86 LEU A C 1 ATOM 354 O O . LEU A 1 58 ? 73.093 -32.218 6.816 1.00 29.42 ? 86 LEU A O 1 ATOM 355 C CB . LEU A 1 58 ? 71.600 -33.272 9.662 1.00 27.74 ? 86 LEU A CB 1 ATOM 356 C CG . LEU A 1 58 ? 70.803 -32.774 10.879 1.00 26.96 ? 86 LEU A CG 1 ATOM 357 C CD1 . LEU A 1 58 ? 71.230 -33.513 12.127 1.00 26.86 ? 86 LEU A CD1 1 ATOM 358 C CD2 . LEU A 1 58 ? 70.907 -31.268 11.090 1.00 24.94 ? 86 LEU A CD2 1 ATOM 359 N N . THR A 1 59 ? 72.090 -34.251 6.725 1.00 29.92 ? 87 THR A N 1 ATOM 360 C CA . THR A 1 59 ? 72.918 -34.727 5.627 1.00 30.57 ? 87 THR A CA 1 ATOM 361 C C . THR A 1 59 ? 72.841 -33.774 4.428 1.00 31.21 ? 87 THR A C 1 ATOM 362 O O . THR A 1 59 ? 73.868 -33.447 3.860 1.00 31.99 ? 87 THR A O 1 ATOM 363 C CB . THR A 1 59 ? 72.569 -36.184 5.210 1.00 30.55 ? 87 THR A CB 1 ATOM 364 O OG1 . THR A 1 59 ? 72.738 -37.051 6.331 1.00 30.80 ? 87 THR A OG1 1 ATOM 365 C CG2 . THR A 1 59 ? 73.472 -36.678 4.075 1.00 29.94 ? 87 THR A CG2 1 ATOM 366 N N . ALA A 1 60 ? 71.637 -33.331 4.067 1.00 31.70 ? 88 ALA A N 1 ATOM 367 C CA . ALA A 1 60 ? 71.414 -32.481 2.895 1.00 32.44 ? 88 ALA A CA 1 ATOM 368 C C . ALA A 1 60 ? 72.033 -31.093 3.039 1.00 33.11 ? 88 ALA A C 1 ATOM 369 O O . ALA A 1 60 ? 72.455 -30.488 2.057 1.00 33.76 ? 88 ALA A O 1 ATOM 370 C CB . ALA A 1 60 ? 69.901 -32.364 2.590 1.00 32.01 ? 88 ALA A CB 1 ATOM 371 N N . ASN A 1 61 ? 72.081 -30.590 4.262 1.00 33.98 ? 89 ASN A N 1 ATOM 372 C CA . ASN A 1 61 ? 72.668 -29.283 4.521 1.00 35.05 ? 89 ASN A CA 1 ATOM 373 C C . ASN A 1 61 ? 74.117 -29.339 5.072 1.00 35.50 ? 89 ASN A C 1 ATOM 374 O O . ASN A 1 61 ? 74.624 -28.360 5.609 1.00 35.10 ? 89 ASN A O 1 ATOM 375 C CB . ASN A 1 61 ? 71.699 -28.448 5.376 1.00 35.01 ? 89 ASN A CB 1 ATOM 376 C CG . ASN A 1 61 ? 70.413 -28.106 4.613 1.00 36.86 ? 89 ASN A CG 1 ATOM 377 O OD1 . ASN A 1 61 ? 70.406 -27.237 3.736 1.00 39.27 ? 89 ASN A OD1 1 ATOM 378 N ND2 . ASN A 1 61 ? 69.335 -28.813 4.916 1.00 37.49 ? 89 ASN A ND2 1 ATOM 379 N N . ASN A 1 62 ? 74.765 -30.498 4.900 1.00 36.40 ? 90 ASN A N 1 ATOM 380 C CA . ASN A 1 62 ? 76.187 -30.728 5.237 1.00 37.54 ? 90 ASN A CA 1 ATOM 381 C C . ASN A 1 62 ? 76.509 -30.474 6.691 1.00 37.66 ? 90 ASN A C 1 ATOM 382 O O . ASN A 1 62 ? 77.453 -29.752 7.003 1.00 37.95 ? 90 ASN A O 1 ATOM 383 C CB . ASN A 1 62 ? 77.130 -29.906 4.335 1.00 37.81 ? 90 ASN A CB 1 ATOM 384 C CG . ASN A 1 62 ? 76.888 -30.163 2.854 1.00 39.66 ? 90 ASN A CG 1 ATOM 385 O OD1 . ASN A 1 62 ? 77.099 -31.276 2.358 1.00 41.77 ? 90 ASN A OD1 1 ATOM 386 N ND2 . ASN A 1 62 ? 76.422 -29.137 2.142 1.00 40.69 ? 90 ASN A ND2 1 ATOM 387 N N . ILE A 1 63 ? 75.698 -31.046 7.575 1.00 38.04 ? 91 ILE A N 1 ATOM 388 C CA . ILE A 1 63 ? 75.921 -30.943 9.017 1.00 38.38 ? 91 ILE A CA 1 ATOM 389 C C . ILE A 1 63 ? 76.176 -32.343 9.566 1.00 39.19 ? 91 ILE A C 1 ATOM 390 O O . ILE A 1 63 ? 75.282 -33.173 9.595 1.00 39.44 ? 91 ILE A O 1 ATOM 391 C CB . ILE A 1 63 ? 74.753 -30.226 9.758 1.00 37.76 ? 91 ILE A CB 1 ATOM 392 C CG1 . ILE A 1 63 ? 74.619 -28.778 9.269 1.00 37.08 ? 91 ILE A CG1 1 ATOM 393 C CG2 . ILE A 1 63 ? 74.996 -30.224 11.256 1.00 37.37 ? 91 ILE A CG2 1 ATOM 394 C CD1 . ILE A 1 63 ? 73.300 -28.092 9.588 1.00 34.10 ? 91 ILE A CD1 1 ATOM 395 N N . GLU A 1 64 ? 77.415 -32.612 9.955 1.00 40.27 ? 92 GLU A N 1 ATOM 396 C CA . GLU A 1 64 ? 77.765 -33.920 10.470 1.00 41.76 ? 92 GLU A CA 1 ATOM 397 C C . GLU A 1 64 ? 77.256 -33.972 11.925 1.00 41.49 ? 92 GLU A C 1 ATOM 398 O O . GLU A 1 64 ? 77.015 -32.922 12.537 1.00 41.28 ? 92 GLU A O 1 ATOM 399 C CB . GLU A 1 64 ? 79.291 -34.170 10.339 1.00 42.54 ? 92 GLU A CB 1 ATOM 400 C CG . GLU A 1 64 ? 79.849 -34.215 8.860 1.00 47.53 ? 92 GLU A CG 1 ATOM 401 C CD . GLU A 1 64 ? 81.397 -34.528 8.738 1.00 54.82 ? 92 GLU A CD 1 ATOM 402 O OE1 . GLU A 1 64 ? 82.180 -34.283 9.699 1.00 56.55 ? 92 GLU A OE1 1 ATOM 403 O OE2 . GLU A 1 64 ? 81.841 -35.029 7.664 1.00 57.14 ? 92 GLU A OE2 1 ATOM 404 N N . ILE A 1 65 ? 77.037 -35.182 12.443 1.00 41.43 ? 93 ILE A N 1 ATOM 405 C CA . ILE A 1 65 ? 76.706 -35.412 13.852 1.00 41.40 ? 93 ILE A CA 1 ATOM 406 C C . ILE A 1 65 ? 77.954 -35.912 14.573 1.00 42.49 ? 93 ILE A C 1 ATOM 407 O O . ILE A 1 65 ? 78.607 -36.846 14.109 1.00 42.33 ? 93 ILE A O 1 ATOM 408 C CB . ILE A 1 65 ? 75.632 -36.496 14.002 1.00 41.08 ? 93 ILE A CB 1 ATOM 409 C CG1 . ILE A 1 65 ? 74.377 -36.104 13.225 1.00 40.63 ? 93 ILE A CG1 1 ATOM 410 C CG2 . ILE A 1 65 ? 75.342 -36.805 15.488 1.00 39.95 ? 93 ILE A CG2 1 ATOM 411 C CD1 . ILE A 1 65 ? 73.443 -37.256 12.949 1.00 39.31 ? 93 ILE A CD1 1 ATOM 412 N N . ASN A 1 66 ? 78.278 -35.297 15.710 1.00 43.66 ? 94 ASN A N 1 ATOM 413 C CA . ASN A 1 66 ? 79.429 -35.714 16.514 1.00 44.64 ? 94 ASN A CA 1 ATOM 414 C C . ASN A 1 66 ? 79.272 -37.144 17.033 1.00 45.60 ? 94 ASN A C 1 ATOM 415 O O . ASN A 1 66 ? 78.157 -37.598 17.308 1.00 45.26 ? 94 ASN A O 1 ATOM 416 C CB . ASN A 1 66 ? 79.637 -34.764 17.700 1.00 44.40 ? 94 ASN A CB 1 ATOM 417 C CG . ASN A 1 66 ? 80.131 -33.385 17.280 1.00 44.39 ? 94 ASN A CG 1 ATOM 418 O OD1 . ASN A 1 66 ? 80.814 -33.232 16.268 1.00 44.26 ? 94 ASN A OD1 1 ATOM 419 N ND2 . ASN A 1 66 ? 79.796 -32.375 18.075 1.00 43.23 ? 94 ASN A ND2 1 ATOM 420 N N . SER A 1 67 ? 80.396 -37.846 17.162 1.00 47.19 ? 95 SER A N 1 ATOM 421 C CA . SER A 1 67 ? 80.397 -39.174 17.775 1.00 48.57 ? 95 SER A CA 1 ATOM 422 C C . SER A 1 67 ? 80.564 -39.084 19.297 1.00 49.22 ? 95 SER A C 1 ATOM 423 O O . SER A 1 67 ? 80.099 -39.960 20.021 1.00 49.33 ? 95 SER A O 1 ATOM 424 C CB . SER A 1 67 ? 81.426 -40.123 17.113 1.00 48.73 ? 95 SER A CB 1 ATOM 425 O OG . SER A 1 67 ? 82.647 -39.473 16.766 1.00 50.16 ? 95 SER A OG 1 ATOM 426 N N . GLU A 1 68 ? 81.187 -38.002 19.771 1.00 50.08 ? 96 GLU A N 1 ATOM 427 C CA . GLU A 1 68 ? 81.434 -37.807 21.196 1.00 51.62 ? 96 GLU A CA 1 ATOM 428 C C . GLU A 1 68 ? 81.169 -36.350 21.429 0.0000 24.67 ? 96 GLU A C 1 ATOM 429 O O . GLU A 1 68 ? 81.625 -35.493 20.672 0.0000 24.56 ? 96 GLU A O 1 ATOM 430 C CB . GLU A 1 68 ? 82.779 -38.415 21.606 1.00 52.36 ? 96 GLU A CB 1 ATOM 431 C CG . GLU A 1 68 ? 83.995 -37.869 20.808 1.00 56.08 ? 96 GLU A CG 1 ATOM 432 C CD . GLU A 1 68 ? 85.065 -38.942 20.523 1.00 60.17 ? 96 GLU A CD 1 ATOM 433 O OE1 . GLU A 1 68 ? 84.775 -39.869 19.720 1.00 61.54 ? 96 GLU A OE1 1 ATOM 434 O OE2 . GLU A 1 68 ? 86.183 -38.858 21.114 1.00 60.43 ? 96 GLU A OE2 1 ATOM 435 N N . ASN A 1 69 ? 80.404 -35.986 22.242 1.00 47.02 ? 97 ASN A N 1 ATOM 436 C CA . ASN A 1 69 ? 80.067 -34.676 22.753 1.00 47.36 ? 97 ASN A CA 1 ATOM 437 C C . ASN A 1 69 ? 81.222 -33.723 22.548 1.00 47.30 ? 97 ASN A C 1 ATOM 438 O O . ASN A 1 69 ? 82.378 -34.076 22.755 1.00 47.73 ? 97 ASN A O 1 ATOM 439 C CB . ASN A 1 69 ? 79.677 -34.700 24.235 1.00 47.41 ? 97 ASN A CB 1 ATOM 440 C CG . ASN A 1 69 ? 79.217 -33.318 24.728 1.00 49.02 ? 97 ASN A CG 1 ATOM 441 O OD1 . ASN A 1 69 ? 80.006 -32.543 25.289 1.00 51.36 ? 97 ASN A OD1 1 ATOM 442 N ND2 . ASN A 1 69 ? 77.955 -32.981 24.451 1.00 48.56 ? 97 ASN A ND2 1 ATOM 443 N N . ASP A 1 70 ? 80.893 -32.511 22.128 1.00 47.11 ? 98 ASP A N 1 ATOM 444 C CA . ASP A 1 70 ? 81.874 -31.467 21.889 1.00 46.96 ? 98 ASP A CA 1 ATOM 445 C C . ASP A 1 70 ? 81.225 -30.146 22.293 1.00 46.69 ? 98 ASP A C 1 ATOM 446 O O . ASP A 1 70 ? 80.258 -29.727 21.647 1.00 46.78 ? 98 ASP A O 1 ATOM 447 C CB . ASP A 1 70 ? 82.274 -31.471 20.404 1.00 46.94 ? 98 ASP A CB 1 ATOM 448 C CG . ASP A 1 70 ? 83.086 -30.233 19.981 1.00 47.04 ? 98 ASP A CG 1 ATOM 449 O OD1 . ASP A 1 70 ? 83.517 -29.427 20.843 1.00 46.29 ? 98 ASP A OD1 1 ATOM 450 O OD2 . ASP A 1 70 ? 83.297 -30.072 18.753 1.00 46.70 ? 98 ASP A OD2 1 ATOM 451 N N . PRO A 1 71 ? 81.743 -29.488 23.358 1.00 46.29 ? 99 PRO A N 1 ATOM 452 C CA . PRO A 1 71 ? 81.060 -28.269 23.816 1.00 45.94 ? 99 PRO A CA 1 ATOM 453 C C . PRO A 1 71 ? 81.148 -27.040 22.888 1.00 45.60 ? 99 PRO A C 1 ATOM 454 O O . PRO A 1 71 ? 80.402 -26.087 23.113 1.00 45.65 ? 99 PRO A O 1 ATOM 455 C CB . PRO A 1 71 ? 81.704 -27.981 25.190 1.00 46.05 ? 99 PRO A CB 1 ATOM 456 C CG . PRO A 1 71 ? 82.501 -29.237 25.538 1.00 46.39 ? 99 PRO A CG 1 ATOM 457 C CD . PRO A 1 71 ? 82.894 -29.829 24.220 1.00 46.20 ? 99 PRO A CD 1 ATOM 458 N N . ASN A 1 72 ? 82.013 -27.059 21.866 1.00 45.11 ? 100 ASN A N 1 ATOM 459 C CA . ASN A 1 72 ? 82.093 -25.953 20.884 1.00 44.59 ? 100 ASN A CA 1 ATOM 460 C C . ASN A 1 72 ? 81.164 -26.069 19.690 1.00 43.48 ? 100 ASN A C 1 ATOM 461 O O . ASN A 1 72 ? 81.311 -25.344 18.699 1.00 43.67 ? 100 ASN A O 1 ATOM 462 C CB . ASN A 1 72 ? 83.523 -25.777 20.375 1.00 45.24 ? 100 ASN A CB 1 ATOM 463 C CG . ASN A 1 72 ? 84.403 -25.131 21.393 1.00 46.98 ? 100 ASN A CG 1 ATOM 464 O OD1 . ASN A 1 72 ? 85.615 -25.339 21.389 1.00 49.82 ? 100 ASN A OD1 1 ATOM 465 N ND2 . ASN A 1 72 ? 83.797 -24.347 22.300 1.00 47.35 ? 100 ASN A ND2 1 ATOM 466 N N . SER A 1 73 ? 80.223 -26.996 19.770 1.00 41.97 ? 101 SER A N 1 ATOM 467 C CA . SER A 1 73 ? 79.300 -27.191 18.668 1.00 40.75 ? 101 SER A CA 1 ATOM 468 C C . SER A 1 73 ? 77.871 -27.202 19.180 1.00 38.92 ? 101 SER A C 1 ATOM 469 O O . SER A 1 73 ? 77.626 -27.554 20.332 1.00 39.06 ? 101 SER A O 1 ATOM 470 C CB . SER A 1 73 ? 79.654 -28.459 17.881 1.00 40.97 ? 101 SER A CB 1 ATOM 471 O OG . SER A 1 73 ? 79.598 -29.586 18.718 1.00 42.61 ? 101 SER A OG 1 ATOM 472 N N . THR A 1 74 ? 76.948 -26.777 18.321 1.00 36.65 ? 102 THR A N 1 ATOM 473 C CA . THR A 1 74 ? 75.531 -26.694 18.635 1.00 34.51 ? 102 THR A CA 1 ATOM 474 C C . THR A 1 74 ? 75.044 -28.048 19.140 1.00 33.42 ? 102 THR A C 1 ATOM 475 O O . THR A 1 74 ? 75.538 -29.085 18.726 1.00 33.25 ? 102 THR A O 1 ATOM 476 C CB . THR A 1 74 ? 74.736 -26.300 17.366 1.00 34.66 ? 102 THR A CB 1 ATOM 477 O OG1 . THR A 1 74 ? 75.338 -25.147 16.752 1.00 34.63 ? 102 THR A OG1 1 ATOM 478 C CG2 . THR A 1 74 ? 73.275 -26.021 17.676 1.00 34.07 ? 102 THR A CG2 1 ATOM 479 N N . THR A 1 75 ? 74.077 -28.032 20.039 1.00 32.17 ? 103 THR A N 1 ATOM 480 C CA . THR A 1 75 ? 73.511 -29.251 20.579 1.00 31.26 ? 103 THR A CA 1 ATOM 481 C C . THR A 1 75 ? 72.031 -29.274 20.246 1.00 30.77 ? 103 THR A C 1 ATOM 482 O O . THR A 1 75 ? 71.334 -28.281 20.432 1.00 31.35 ? 103 THR A O 1 ATOM 483 C CB . THR A 1 75 ? 73.760 -29.349 22.122 1.00 31.27 ? 103 THR A CB 1 ATOM 484 O OG1 . THR A 1 75 ? 75.171 -29.392 22.359 1.00 32.73 ? 103 THR A OG1 1 ATOM 485 C CG2 . THR A 1 75 ? 73.153 -30.603 22.725 1.00 30.20 ? 103 THR A CG2 1 ATOM 486 N N . LEU A 1 76 ? 71.558 -30.408 19.738 1.00 30.09 ? 104 LEU A N 1 ATOM 487 C CA . LEU A 1 76 ? 70.145 -30.607 19.421 1.00 29.10 ? 104 LEU A CA 1 ATOM 488 C C . LEU A 1 76 ? 69.590 -31.706 20.310 1.00 28.44 ? 104 LEU A C 1 ATOM 489 O O . LEU A 1 76 ? 70.081 -32.830 20.287 1.00 28.95 ? 104 LEU A O 1 ATOM 490 C CB . LEU A 1 76 ? 70.009 -31.017 17.961 1.00 29.09 ? 104 LEU A CB 1 ATOM 491 C CG . LEU A 1 76 ? 68.795 -30.538 17.153 1.00 30.76 ? 104 LEU A CG 1 ATOM 492 C CD1 . LEU A 1 76 ? 69.115 -30.529 15.647 1.00 31.35 ? 104 LEU A CD1 1 ATOM 493 C CD2 . LEU A 1 76 ? 67.503 -31.334 17.446 1.00 30.67 ? 104 LEU A CD2 1 ATOM 494 N N . ILE A 1 77 ? 68.583 -31.391 21.111 1.00 27.33 ? 105 ILE A N 1 ATOM 495 C CA . ILE A 1 77 ? 67.954 -32.395 21.949 1.00 26.42 ? 105 ILE A CA 1 ATOM 496 C C . ILE A 1 77 ? 66.532 -32.594 21.454 1.00 25.82 ? 105 ILE A C 1 ATOM 497 O O . ILE A 1 77 ? 65.809 -31.621 21.211 1.00 25.99 ? 105 ILE A O 1 ATOM 498 C CB . ILE A 1 77 ? 67.908 -31.979 23.432 1.00 26.71 ? 105 ILE A CB 1 ATOM 499 C CG1 . ILE A 1 77 ? 69.289 -31.611 23.953 1.00 28.30 ? 105 ILE A CG1 1 ATOM 500 C CG2 . ILE A 1 77 ? 67.362 -33.098 24.297 1.00 26.52 ? 105 ILE A CG2 1 ATOM 501 C CD1 . ILE A 1 77 ? 69.467 -30.154 24.184 1.00 29.45 ? 105 ILE A CD1 1 ATOM 502 N N . ILE A 1 78 ? 66.137 -33.857 21.325 1.00 24.67 ? 106 ILE A N 1 ATOM 503 C CA . ILE A 1 78 ? 64.863 -34.237 20.735 1.00 23.43 ? 106 ILE A CA 1 ATOM 504 C C . ILE A 1 78 ? 64.264 -35.388 21.541 1.00 23.05 ? 106 ILE A C 1 ATOM 505 O O . ILE A 1 78 ? 65.010 -36.179 22.104 1.00 22.65 ? 106 ILE A O 1 ATOM 506 C CB . ILE A 1 78 ? 65.039 -34.613 19.232 1.00 22.94 ? 106 ILE A CB 1 ATOM 507 C CG1 . ILE A 1 78 ? 63.703 -35.000 18.595 1.00 21.83 ? 106 ILE A CG1 1 ATOM 508 C CG2 . ILE A 1 78 ? 66.057 -35.731 19.050 1.00 22.92 ? 106 ILE A CG2 1 ATOM 509 C CD1 . ILE A 1 78 ? 63.720 -34.916 17.092 1.00 19.42 ? 106 ILE A CD1 1 ATOM 510 N N . GLY A 1 79 ? 62.930 -35.455 21.615 1.00 22.70 ? 107 GLY A N 1 ATOM 511 C CA . GLY A 1 79 ? 62.230 -36.504 22.370 1.00 22.42 ? 107 GLY A CA 1 ATOM 512 C C . GLY A 1 79 ? 60.756 -36.219 22.594 1.00 22.54 ? 107 GLY A C 1 ATOM 513 O O . GLY A 1 79 ? 60.295 -35.123 22.290 1.00 22.96 ? 107 GLY A O 1 ATOM 514 N N . GLU A 1 80 ? 60.018 -37.209 23.103 1.00 22.54 ? 108 GLU A N 1 ATOM 515 C CA . GLU A 1 80 ? 58.617 -37.037 23.520 1.00 22.97 ? 108 GLU A CA 1 ATOM 516 C C . GLU A 1 80 ? 58.526 -36.753 25.024 1.00 23.50 ? 108 GLU A C 1 ATOM 517 O O . GLU A 1 80 ? 59.436 -37.062 25.803 1.00 23.90 ? 108 GLU A O 1 ATOM 518 C CB . GLU A 1 80 ? 57.786 -38.297 23.225 1.00 22.94 ? 108 GLU A CB 1 ATOM 519 C CG . GLU A 1 80 ? 57.552 -38.637 21.751 1.00 24.81 ? 108 GLU A CG 1 ATOM 520 C CD . GLU A 1 80 ? 58.769 -39.272 21.061 1.00 28.17 ? 108 GLU A CD 1 ATOM 521 O OE1 . GLU A 1 80 ? 59.231 -40.373 21.483 1.00 32.69 ? 108 GLU A OE1 1 ATOM 522 O OE2 . GLU A 1 80 ? 59.268 -38.670 20.082 1.00 27.08 ? 108 GLU A OE2 1 ATOM 523 N N . VAL A 1 81 ? 57.419 -36.160 25.435 1.00 24.12 ? 109 VAL A N 1 ATOM 524 C CA . VAL A 1 81 ? 57.136 -35.935 26.834 1.00 24.91 ? 109 VAL A CA 1 ATOM 525 C C . VAL A 1 81 ? 57.450 -37.242 27.601 1.00 26.20 ? 109 VAL A C 1 ATOM 526 O O . VAL A 1 81 ? 58.233 -37.240 28.608 1.00 26.92 ? 109 VAL A O 1 ATOM 527 C CB . VAL A 1 81 ? 55.656 -35.493 26.985 1.00 24.54 ? 109 VAL A CB 1 ATOM 528 C CG1 . VAL A 1 81 ? 55.226 -35.501 28.415 1.00 24.37 ? 109 VAL A CG1 1 ATOM 529 C CG2 . VAL A 1 81 ? 55.452 -34.111 26.395 1.00 24.46 ? 109 VAL A CG2 1 ATOM 530 N N . ASP A 1 82 ? 56.910 -38.342 27.063 1.00 26.69 ? 110 ASP A N 1 ATOM 531 C CA . ASP A 1 82 ? 56.959 -39.660 27.681 1.00 27.89 ? 110 ASP A CA 1 ATOM 532 C C . ASP A 1 82 ? 58.256 -40.427 27.523 1.00 28.34 ? 110 ASP A C 1 ATOM 533 O O . ASP A 1 82 ? 58.312 -41.602 27.854 1.00 28.46 ? 110 ASP A O 1 ATOM 534 C CB . ASP A 1 82 ? 55.739 -40.531 27.311 1.00 27.90 ? 110 ASP A CB 1 ATOM 535 C CG . ASP A 1 82 ? 55.841 -41.181 25.916 1.00 29.21 ? 110 ASP A CG 1 ATOM 536 O OD1 . ASP A 1 82 ? 56.814 -40.922 25.176 1.00 29.78 ? 110 ASP A OD1 1 ATOM 537 O OD2 . ASP A 1 82 ? 54.911 -41.953 25.557 1.00 29.80 ? 110 ASP A OD2 1 ATOM 538 N N . ASP A 1 83 ? 59.296 -39.764 27.041 1.00 29.92 ? 111 ASP A N 1 ATOM 539 C CA . ASP A 1 83 ? 60.655 -40.259 27.227 1.00 31.76 ? 111 ASP A CA 1 ATOM 540 C C . ASP A 1 83 ? 61.206 -39.597 28.481 1.00 33.23 ? 111 ASP A C 1 ATOM 541 O O . ASP A 1 83 ? 60.993 -38.378 28.713 1.00 33.43 ? 111 ASP A O 1 ATOM 542 C CB . ASP A 1 83 ? 61.547 -39.908 26.046 1.00 31.91 ? 111 ASP A CB 1 ATOM 543 C CG . ASP A 1 83 ? 61.028 -40.473 24.720 1.00 33.58 ? 111 ASP A CG 1 ATOM 544 O OD1 . ASP A 1 83 ? 60.200 -41.418 24.712 1.00 33.48 ? 111 ASP A OD1 1 ATOM 545 O OD2 . ASP A 1 83 ? 61.445 -39.958 23.667 1.00 33.88 ? 111 ASP A OD2 1 ATOM 546 N N . ASP A 1 84 ? 61.865 -40.405 29.317 1.00 34.49 ? 112 ASP A N 1 ATOM 547 C CA . ASP A 1 84 ? 62.569 -39.879 30.475 1.00 35.62 ? 112 ASP A CA 1 ATOM 548 C C . ASP A 1 84 ? 63.946 -39.431 30.021 1.00 35.38 ? 112 ASP A C 1 ATOM 549 O O . ASP A 1 84 ? 64.903 -40.195 30.081 1.00 35.32 ? 112 ASP A O 1 ATOM 550 C CB . ASP A 1 84 ? 62.664 -40.919 31.616 1.00 36.52 ? 112 ASP A CB 1 ATOM 551 C CG . ASP A 1 84 ? 63.028 -40.290 32.990 1.00 38.45 ? 112 ASP A CG 1 ATOM 552 O OD1 . ASP A 1 84 ? 63.584 -39.158 33.031 1.00 40.55 ? 112 ASP A OD1 1 ATOM 553 O OD2 . ASP A 1 84 ? 62.754 -40.948 34.030 1.00 40.26 ? 112 ASP A OD2 1 ATOM 554 N N . ILE A 1 85 ? 64.015 -38.184 29.563 1.00 35.49 ? 113 ILE A N 1 ATOM 555 C CA . ILE A 1 85 ? 65.271 -37.548 29.194 1.00 35.32 ? 113 ILE A CA 1 ATOM 556 C C . ILE A 1 85 ? 65.304 -36.130 29.808 1.00 35.88 ? 113 ILE A C 1 ATOM 557 O O . ILE A 1 85 ? 64.684 -35.185 29.304 1.00 36.15 ? 113 ILE A O 1 ATOM 558 C CB . ILE A 1 85 ? 65.495 -37.582 27.665 1.00 35.21 ? 113 ILE A CB 1 ATOM 559 C CG1 . ILE A 1 85 ? 66.738 -36.787 27.292 1.00 35.06 ? 113 ILE A CG1 1 ATOM 560 C CG2 . ILE A 1 85 ? 64.232 -37.148 26.900 1.00 35.04 ? 113 ILE A CG2 1 ATOM 561 C CD1 . ILE A 1 85 ? 66.873 -36.532 25.827 1.00 36.21 ? 113 ILE A CD1 1 ATOM 562 N N . PRO A 1 86 ? 65.992 -35.999 30.950 1.00 36.16 ? 114 PRO A N 1 ATOM 563 C CA . PRO A 1 86 ? 66.078 -34.710 31.662 1.00 35.95 ? 114 PRO A CA 1 ATOM 564 C C . PRO A 1 86 ? 66.875 -33.607 30.947 1.00 35.65 ? 114 PRO A C 1 ATOM 565 O O . PRO A 1 86 ? 66.538 -32.417 31.120 1.00 35.61 ? 114 PRO A O 1 ATOM 566 C CB . PRO A 1 86 ? 66.760 -35.085 32.995 1.00 36.35 ? 114 PRO A CB 1 ATOM 567 C CG . PRO A 1 86 ? 66.526 -36.616 33.145 1.00 35.85 ? 114 PRO A CG 1 ATOM 568 C CD . PRO A 1 86 ? 66.568 -37.122 31.734 1.00 36.24 ? 114 PRO A CD 1 ATOM 569 N N . GLU A 1 87 ? 67.907 -33.981 30.171 1.00 35.00 ? 115 GLU A N 1 ATOM 570 C CA . GLU A 1 87 ? 68.729 -32.997 29.449 1.00 34.40 ? 115 GLU A CA 1 ATOM 571 C C . GLU A 1 87 ? 67.850 -32.189 28.479 1.00 34.43 ? 115 GLU A C 1 ATOM 572 O O . GLU A 1 87 ? 68.199 -31.059 28.105 1.00 35.07 ? 115 GLU A O 1 ATOM 573 C CB . GLU A 1 87 ? 69.937 -33.648 28.759 1.00 34.02 ? 115 GLU A CB 1 ATOM 574 C CG . GLU A 1 87 ? 70.838 -34.098 29.774 0.0000 20.00 ? 115 GLU A CG 1 ATOM 575 C CD . GLU A 1 87 ? 71.990 -34.812 29.099 0.0000 20.00 ? 115 GLU A CD 1 ATOM 576 O OE1 . GLU A 1 87 ? 71.899 -35.045 27.890 0.0000 20.00 ? 115 GLU A OE1 1 ATOM 577 O OE2 . GLU A 1 87 ? 73.001 -35.139 29.767 0.0000 20.00 ? 115 GLU A OE2 1 ATOM 578 N N . LEU A 1 88 ? 66.683 -32.751 28.134 1.00 33.99 ? 116 LEU A N 1 ATOM 579 C CA . LEU A 1 88 ? 65.677 -32.087 27.289 1.00 33.24 ? 116 LEU A CA 1 ATOM 580 C C . LEU A 1 88 ? 64.872 -31.054 28.047 1.00 33.40 ? 116 LEU A C 1 ATOM 581 O O . LEU A 1 88 ? 64.708 -29.935 27.571 1.00 33.80 ? 116 LEU A O 1 ATOM 582 C CB . LEU A 1 88 ? 64.721 -33.096 26.615 1.00 33.04 ? 116 LEU A CB 1 ATOM 583 C CG . LEU A 1 88 ? 63.552 -32.524 25.782 1.00 31.88 ? 116 LEU A CG 1 ATOM 584 C CD1 . LEU A 1 88 ? 64.017 -31.656 24.590 1.00 29.63 ? 116 LEU A CD1 1 ATOM 585 C CD2 . LEU A 1 88 ? 62.645 -33.618 25.313 1.00 30.09 ? 116 LEU A CD2 1 ATOM 586 N N . ASP A 1 89 ? 64.347 -31.435 29.205 1.00 33.64 ? 117 ASP A N 1 ATOM 587 C CA . ASP A 1 89 ? 63.631 -30.506 30.075 1.00 33.94 ? 117 ASP A CA 1 ATOM 588 C C . ASP A 1 89 ? 64.481 -29.308 30.496 1.00 34.21 ? 117 ASP A C 1 ATOM 589 O O . ASP A 1 89 ? 63.988 -28.198 30.551 1.00 34.08 ? 117 ASP A O 1 ATOM 590 C CB . ASP A 1 89 ? 63.064 -31.237 31.296 1.00 33.91 ? 117 ASP A CB 1 ATOM 591 C CG . ASP A 1 89 ? 61.732 -31.917 31.003 1.00 34.19 ? 117 ASP A CG 1 ATOM 592 O OD1 . ASP A 1 89 ? 61.320 -31.965 29.816 1.00 31.38 ? 117 ASP A OD1 1 ATOM 593 O OD2 . ASP A 1 89 ? 61.093 -32.401 31.967 1.00 35.22 ? 117 ASP A OD2 1 ATOM 594 N N . GLU A 1 90 ? 65.758 -29.542 30.775 1.00 35.11 ? 118 GLU A N 1 ATOM 595 C CA . GLU A 1 90 ? 66.723 -28.473 31.053 1.00 36.16 ? 118 GLU A CA 1 ATOM 596 C C . GLU A 1 90 ? 66.739 -27.414 29.915 1.00 35.42 ? 118 GLU A C 1 ATOM 597 O O . GLU A 1 90 ? 66.607 -26.216 30.187 1.00 35.56 ? 118 GLU A O 1 ATOM 598 C CB . GLU A 1 90 ? 68.132 -29.077 31.286 1.00 37.20 ? 118 GLU A CB 1 ATOM 599 C CG . GLU A 1 90 ? 69.071 -28.317 32.258 1.00 41.94 ? 118 GLU A CG 1 ATOM 600 C CD . GLU A 1 90 ? 70.589 -28.553 31.958 1.00 49.67 ? 118 GLU A CD 1 ATOM 601 O OE1 . GLU A 1 90 ? 71.131 -29.680 32.224 1.00 50.81 ? 118 GLU A OE1 1 ATOM 602 O OE2 . GLU A 1 90 ? 71.243 -27.582 31.468 1.00 51.85 ? 118 GLU A OE2 1 ATOM 603 N N . ALA A 1 91 ? 66.866 -27.853 28.656 1.00 34.47 ? 119 ALA A N 1 ATOM 604 C CA . ALA A 1 91 ? 66.985 -26.924 27.505 1.00 33.23 ? 119 ALA A CA 1 ATOM 605 C C . ALA A 1 91 ? 65.681 -26.257 27.057 1.00 32.62 ? 119 ALA A C 1 ATOM 606 O O . ALA A 1 91 ? 65.705 -25.275 26.326 1.00 32.36 ? 119 ALA A O 1 ATOM 607 C CB . ALA A 1 91 ? 67.659 -27.601 26.329 1.00 32.95 ? 119 ALA A CB 1 ATOM 608 N N . LEU A 1 92 ? 64.549 -26.793 27.489 1.00 32.28 ? 120 LEU A N 1 ATOM 609 C CA . LEU A 1 92 ? 63.260 -26.196 27.173 1.00 32.46 ? 120 LEU A CA 1 ATOM 610 C C . LEU A 1 92 ? 62.990 -24.966 28.024 1.00 33.65 ? 120 LEU A C 1 ATOM 611 O O . LEU A 1 92 ? 62.220 -24.076 27.628 1.00 33.86 ? 120 LEU A O 1 ATOM 612 C CB . LEU A 1 92 ? 62.136 -27.203 27.371 1.00 31.94 ? 120 LEU A CB 1 ATOM 613 C CG . LEU A 1 92 ? 61.893 -28.271 26.319 1.00 29.92 ? 120 LEU A CG 1 ATOM 614 C CD1 . LEU A 1 92 ? 60.837 -29.218 26.838 1.00 28.24 ? 120 LEU A CD1 1 ATOM 615 C CD2 . LEU A 1 92 ? 61.458 -27.636 25.022 1.00 27.82 ? 120 LEU A CD2 1 ATOM 616 N N . ASN A 1 93 ? 63.591 -24.939 29.217 1.00 35.01 ? 121 ASN A N 1 ATOM 617 C CA . ASN A 1 93 ? 63.639 -23.732 30.029 1.00 35.69 ? 121 ASN A CA 1 ATOM 618 C C . ASN A 1 93 ? 62.226 -23.285 30.440 1.00 35.15 ? 121 ASN A C 1 ATOM 619 O O . ASN A 1 93 ? 61.826 -22.134 30.231 1.00 35.28 ? 121 ASN A O 1 ATOM 620 C CB . ASN A 1 93 ? 64.374 -22.649 29.220 1.00 36.47 ? 121 ASN A CB 1 ATOM 621 C CG . ASN A 1 93 ? 64.835 -21.469 30.074 1.00 39.88 ? 121 ASN A CG 1 ATOM 622 O OD1 . ASN A 1 93 ? 64.639 -20.304 29.685 1.00 41.76 ? 121 ASN A OD1 1 ATOM 623 N ND2 . ASN A 1 93 ? 65.463 -21.758 31.230 1.00 41.03 ? 121 ASN A ND2 1 ATOM 624 N N . GLY A 1 94 ? 61.466 -24.224 30.995 1.00 34.41 ? 122 GLY A N 1 ATOM 625 C CA . GLY A 1 94 ? 60.150 -23.934 31.550 1.00 33.89 ? 122 GLY A CA 1 ATOM 626 C C . GLY A 1 94 ? 59.038 -24.065 30.535 1.00 33.61 ? 122 GLY A C 1 ATOM 627 O O . GLY A 1 94 ? 57.850 -24.070 30.890 1.00 33.30 ? 122 GLY A O 1 ATOM 628 N N . THR A 1 95 ? 59.428 -24.143 29.264 1.00 33.10 ? 123 THR A N 1 ATOM 629 C CA . THR A 1 95 ? 58.497 -24.436 28.167 1.00 32.78 ? 123 THR A CA 1 ATOM 630 C C . THR A 1 95 ? 58.241 -25.939 28.135 1.00 32.46 ? 123 THR A C 1 ATOM 631 O O . THR A 1 95 ? 59.176 -26.721 28.250 1.00 32.51 ? 123 THR A O 1 ATOM 632 C CB . THR A 1 95 ? 59.082 -23.983 26.816 1.00 32.61 ? 123 THR A CB 1 ATOM 633 O OG1 . THR A 1 95 ? 59.291 -22.576 26.864 1.00 33.79 ? 123 THR A OG1 1 ATOM 634 C CG2 . THR A 1 95 ? 58.154 -24.273 25.666 1.00 31.52 ? 123 THR A CG2 1 ATOM 635 N N . THR A 1 96 ? 56.981 -26.332 27.981 1.00 31.75 ? 124 THR A N 1 ATOM 636 C CA . THR A 1 96 ? 56.624 -27.743 28.000 1.00 31.21 ? 124 THR A CA 1 ATOM 637 C C . THR A 1 96 ? 55.630 -28.101 26.894 1.00 30.93 ? 124 THR A C 1 ATOM 638 O O . THR A 1 96 ? 54.854 -27.259 26.451 1.00 30.64 ? 124 THR A O 1 ATOM 639 C CB . THR A 1 96 ? 56.072 -28.180 29.409 1.00 31.16 ? 124 THR A CB 1 ATOM 640 O OG1 . THR A 1 96 ? 55.858 -29.597 29.436 1.00 30.71 ? 124 THR A OG1 1 ATOM 641 C CG2 . THR A 1 96 ? 54.754 -27.500 29.730 1.00 30.60 ? 124 THR A CG2 1 ATOM 642 N N . ALA A 1 97 ? 55.660 -29.358 26.468 1.00 30.66 ? 125 ALA A N 1 ATOM 643 C CA . ALA A 1 97 ? 54.646 -29.900 25.573 1.00 30.62 ? 125 ALA A CA 1 ATOM 644 C C . ALA A 1 97 ? 53.659 -30.781 26.331 1.00 30.76 ? 125 ALA A C 1 ATOM 645 O O . ALA A 1 97 ? 52.716 -31.302 25.750 1.00 31.10 ? 125 ALA A O 1 ATOM 646 C CB . ALA A 1 97 ? 55.299 -30.674 24.431 1.00 30.27 ? 125 ALA A CB 1 ATOM 647 N N . GLU A 1 98 ? 53.859 -30.928 27.635 1.00 31.14 ? 126 GLU A N 1 ATOM 648 C CA . GLU A 1 98 ? 53.022 -31.815 28.439 1.00 31.75 ? 126 GLU A CA 1 ATOM 649 C C . GLU A 1 98 ? 51.529 -31.500 28.341 1.00 31.25 ? 126 GLU A C 1 ATOM 650 O O . GLU A 1 98 ? 50.691 -32.399 28.266 1.00 31.19 ? 126 GLU A O 1 ATOM 651 C CB . GLU A 1 98 ? 53.470 -31.800 29.905 1.00 32.53 ? 126 GLU A CB 1 ATOM 652 C CG . GLU A 1 98 ? 52.615 -32.679 30.823 1.00 35.95 ? 126 GLU A CG 1 ATOM 653 C CD . GLU A 1 98 ? 53.227 -32.883 32.202 1.00 41.91 ? 126 GLU A CD 1 ATOM 654 O OE1 . GLU A 1 98 ? 54.113 -32.095 32.613 1.00 44.55 ? 126 GLU A OE1 1 ATOM 655 O OE2 . GLU A 1 98 ? 52.817 -33.842 32.886 1.00 43.44 ? 126 GLU A OE2 1 ATOM 656 N N . ASN A 1 99 ? 51.190 -30.226 28.354 1.00 30.99 ? 127 ASN A N 1 ATOM 657 C CA . ASN A 1 99 ? 49.785 -29.851 28.455 1.00 31.41 ? 127 ASN A CA 1 ATOM 658 C C . ASN A 1 99 ? 49.126 -29.597 27.090 1.00 30.74 ? 127 ASN A C 1 ATOM 659 O O . ASN A 1 99 ? 48.005 -29.107 27.037 1.00 30.30 ? 127 ASN A O 1 ATOM 660 C CB . ASN A 1 99 ? 49.630 -28.624 29.374 1.00 32.02 ? 127 ASN A CB 1 ATOM 661 C CG . ASN A 1 99 ? 50.533 -27.428 28.943 1.00 35.05 ? 127 ASN A CG 1 ATOM 662 O OD1 . ASN A 1 99 ? 51.343 -27.525 27.988 1.00 35.81 ? 127 ASN A OD1 1 ATOM 663 N ND2 . ASN A 1 99 ? 50.394 -26.302 29.659 1.00 35.04 ? 127 ASN A ND2 1 ATOM 664 N N . LEU A 1 100 ? 49.821 -29.930 25.994 1.00 29.70 ? 128 LEU A N 1 ATOM 665 C CA . LEU A 1 100 ? 49.321 -29.625 24.656 1.00 28.25 ? 128 LEU A CA 1 ATOM 666 C C . LEU A 1 100 ? 48.479 -30.767 24.124 1.00 28.51 ? 128 LEU A C 1 ATOM 667 O O . LEU A 1 100 ? 48.569 -31.902 24.614 1.00 28.72 ? 128 LEU A O 1 ATOM 668 C CB . LEU A 1 100 ? 50.462 -29.312 23.693 1.00 27.33 ? 128 LEU A CB 1 ATOM 669 C CG . LEU A 1 100 ? 51.461 -28.233 24.103 1.00 26.47 ? 128 LEU A CG 1 ATOM 670 C CD1 . LEU A 1 100 ? 52.587 -28.142 23.075 1.00 23.81 ? 128 LEU A CD1 1 ATOM 671 C CD2 . LEU A 1 100 ? 50.804 -26.854 24.352 1.00 22.92 ? 128 LEU A CD2 1 ATOM 672 N N . LYS A 1 101 ? 47.642 -30.474 23.128 1.00 28.54 ? 129 LYS A N 1 ATOM 673 C CA . LYS A 1 101 ? 46.821 -31.529 22.534 1.00 28.10 ? 129 LYS A CA 1 ATOM 674 C C . LYS A 1 101 ? 47.675 -32.505 21.713 1.00 27.18 ? 129 LYS A C 1 ATOM 675 O O . LYS A 1 101 ? 48.825 -32.201 21.380 1.00 26.95 ? 129 LYS A O 1 ATOM 676 C CB . LYS A 1 101 ? 45.596 -30.972 21.787 1.00 28.33 ? 129 LYS A CB 1 ATOM 677 C CG . LYS A 1 101 ? 45.842 -30.265 20.473 1.00 30.10 ? 129 LYS A CG 1 ATOM 678 C CD . LYS A 1 101 ? 44.608 -30.392 19.551 1.00 32.25 ? 129 LYS A CD 1 ATOM 679 C CE . LYS A 1 101 ? 43.551 -29.318 19.810 1.00 33.85 ? 129 LYS A CE 1 ATOM 680 N NZ . LYS A 1 101 ? 42.521 -29.309 18.712 1.00 35.39 ? 129 LYS A NZ 1 ATOM 681 N N . GLU A 1 102 ? 47.149 -33.701 21.454 1.00 26.50 ? 130 GLU A N 1 ATOM 682 C CA . GLU A 1 102 ? 47.887 -34.687 20.659 1.00 25.65 ? 130 GLU A CA 1 ATOM 683 C C . GLU A 1 102 ? 48.397 -34.057 19.336 1.00 24.61 ? 130 GLU A C 1 ATOM 684 O O . GLU A 1 102 ? 47.733 -33.201 18.745 1.00 24.24 ? 130 GLU A O 1 ATOM 685 C CB . GLU A 1 102 ? 47.058 -35.982 20.464 1.00 26.15 ? 130 GLU A CB 1 ATOM 686 C CG . GLU A 1 102 ? 45.811 -35.874 19.559 1.00 27.79 ? 130 GLU A CG 1 ATOM 687 C CD . GLU A 1 102 ? 44.739 -36.880 19.901 0.010 27.34 ? 130 GLU A CD 1 ATOM 688 O OE1 . GLU A 1 102 ? 45.000 -37.799 20.707 0.010 27.40 ? 130 GLU A OE1 1 ATOM 689 O OE2 . GLU A 1 102 ? 43.622 -36.754 19.357 0.010 27.40 ? 130 GLU A OE2 1 ATOM 690 N N . GLU A 1 103 ? 49.592 -34.460 18.912 1.00 23.46 ? 131 GLU A N 1 ATOM 691 C CA . GLU A 1 103 ? 50.262 -33.895 17.725 1.00 22.35 ? 131 GLU A CA 1 ATOM 692 C C . GLU A 1 103 ? 50.971 -32.582 17.994 1.00 22.11 ? 131 GLU A C 1 ATOM 693 O O . GLU A 1 103 ? 51.617 -32.064 17.092 1.00 22.09 ? 131 GLU A O 1 ATOM 694 C CB . GLU A 1 103 ? 49.319 -33.712 16.535 1.00 21.65 ? 131 GLU A CB 1 ATOM 695 C CG . GLU A 1 103 ? 48.902 -34.961 15.863 1.00 20.31 ? 131 GLU A CG 1 ATOM 696 C CD . GLU A 1 103 ? 48.000 -34.692 14.689 1.00 24.03 ? 131 GLU A CD 1 ATOM 697 O OE1 . GLU A 1 103 ? 46.988 -33.972 14.848 1.00 26.40 ? 131 GLU A OE1 1 ATOM 698 O OE2 . GLU A 1 103 ? 48.286 -35.212 13.594 1.00 26.78 ? 131 GLU A OE2 1 ATOM 699 N N . GLY A 1 104 ? 50.845 -32.039 19.210 1.00 21.30 ? 132 GLY A N 1 ATOM 700 C CA . GLY A 1 104 ? 51.519 -30.785 19.565 1.00 20.39 ? 132 GLY A CA 1 ATOM 701 C C . GLY A 1 104 ? 52.994 -30.932 19.920 1.00 20.17 ? 132 GLY A C 1 ATOM 702 O O . GLY A 1 104 ? 53.482 -32.041 20.153 1.00 20.33 ? 132 GLY A O 1 ATOM 703 N N . TYR A 1 105 ? 53.721 -29.824 19.967 1.00 19.53 ? 133 TYR A N 1 ATOM 704 C CA . TYR A 1 105 ? 55.124 -29.887 20.341 1.00 19.98 ? 133 TYR A CA 1 ATOM 705 C C . TYR A 1 105 ? 55.584 -28.553 20.910 1.00 20.48 ? 133 TYR A C 1 ATOM 706 O O . TYR A 1 105 ? 54.887 -27.546 20.810 1.00 20.82 ? 133 TYR A O 1 ATOM 707 C CB . TYR A 1 105 ? 56.015 -30.272 19.135 1.00 19.95 ? 133 TYR A CB 1 ATOM 708 C CG . TYR A 1 105 ? 56.013 -29.205 18.065 1.00 20.72 ? 133 TYR A CG 1 ATOM 709 C CD1 . TYR A 1 105 ? 56.919 -28.133 18.113 1.00 20.86 ? 133 TYR A CD1 1 ATOM 710 C CD2 . TYR A 1 105 ? 55.076 -29.234 17.029 1.00 19.22 ? 133 TYR A CD2 1 ATOM 711 C CE1 . TYR A 1 105 ? 56.886 -27.125 17.145 1.00 20.65 ? 133 TYR A CE1 1 ATOM 712 C CE2 . TYR A 1 105 ? 55.042 -28.229 16.062 1.00 19.18 ? 133 TYR A CE2 1 ATOM 713 C CZ . TYR A 1 105 ? 55.943 -27.183 16.124 1.00 19.27 ? 133 TYR A CZ 1 ATOM 714 O OH . TYR A 1 105 ? 55.894 -26.195 15.169 1.00 17.63 ? 133 TYR A OH 1 ATOM 715 N N . ALA A 1 106 ? 56.781 -28.561 21.484 1.00 20.77 ? 134 ALA A N 1 ATOM 716 C CA . ALA A 1 106 ? 57.448 -27.364 21.926 1.00 20.40 ? 134 ALA A CA 1 ATOM 717 C C . ALA A 1 106 ? 58.792 -27.354 21.256 1.00 20.47 ? 134 ALA A C 1 ATOM 718 O O . ALA A 1 106 ? 59.416 -28.402 21.123 1.00 20.16 ? 134 ALA A O 1 ATOM 719 C CB . ALA A 1 106 ? 57.623 -27.392 23.412 1.00 20.56 ? 134 ALA A CB 1 ATOM 720 N N . LEU A 1 107 ? 59.238 -26.169 20.845 1.00 20.53 ? 135 LEU A N 1 ATOM 721 C CA . LEU A 1 107 ? 60.537 -26.002 20.227 1.00 20.59 ? 135 LEU A CA 1 ATOM 722 C C . LEU A 1 107 ? 61.201 -24.761 20.827 1.00 21.35 ? 135 LEU A C 1 ATOM 723 O O . LEU A 1 107 ? 60.563 -23.714 20.961 1.00 21.59 ? 135 LEU A O 1 ATOM 724 C CB . LEU A 1 107 ? 60.392 -25.895 18.703 1.00 20.25 ? 135 LEU A CB 1 ATOM 725 C CG . LEU A 1 107 ? 61.679 -25.910 17.873 1.00 19.40 ? 135 LEU A CG 1 ATOM 726 C CD1 . LEU A 1 107 ? 61.469 -26.466 16.480 1.00 17.90 ? 135 LEU A CD1 1 ATOM 727 C CD2 . LEU A 1 107 ? 62.240 -24.536 17.779 1.00 19.24 ? 135 LEU A CD2 1 ATOM 728 N N . VAL A 1 108 ? 62.470 -24.887 21.209 1.00 21.56 ? 136 VAL A N 1 ATOM 729 C CA . VAL A 1 108 ? 63.207 -23.786 21.805 1.00 21.74 ? 136 VAL A CA 1 ATOM 730 C C . VAL A 1 108 ? 64.602 -23.745 21.194 1.00 23.03 ? 136 VAL A C 1 ATOM 731 O O . VAL A 1 108 ? 65.313 -24.739 21.239 1.00 24.12 ? 136 VAL A O 1 ATOM 732 C CB . VAL A 1 108 ? 63.305 -23.921 23.362 1.00 21.79 ? 136 VAL A CB 1 ATOM 733 C CG1 . VAL A 1 108 ? 64.242 -22.860 23.943 1.00 20.96 ? 136 VAL A CG1 1 ATOM 734 C CG2 . VAL A 1 108 ? 61.930 -23.834 24.024 1.00 19.40 ? 136 VAL A CG2 1 ATOM 735 N N . SER A 1 109 ? 64.983 -22.627 20.579 1.00 23.72 ? 137 SER A N 1 ATOM 736 C CA . SER A 1 109 ? 66.371 -22.414 20.183 1.00 24.70 ? 137 SER A CA 1 ATOM 737 C C . SER A 1 109 ? 66.939 -21.143 20.861 1.00 25.63 ? 137 SER A C 1 ATOM 738 O O . SER A 1 109 ? 66.407 -20.041 20.666 1.00 25.72 ? 137 SER A O 1 ATOM 739 C CB . SER A 1 109 ? 66.494 -22.355 18.670 1.00 24.25 ? 137 SER A CB 1 ATOM 740 O OG . SER A 1 109 ? 65.601 -21.404 18.138 1.00 25.91 ? 137 SER A OG 1 ATOM 741 N N . ASN A 1 110 ? 67.971 -21.312 21.696 1.00 25.87 ? 138 ASN A N 1 ATOM 742 C CA . ASN A 1 110 ? 68.599 -20.200 22.439 1.00 26.80 ? 138 ASN A CA 1 ATOM 743 C C . ASN A 1 110 ? 69.977 -20.633 22.898 1.00 27.41 ? 138 ASN A C 1 ATOM 744 O O . ASN A 1 110 ? 70.161 -21.783 23.333 1.00 27.68 ? 138 ASN A O 1 ATOM 745 C CB . ASN A 1 110 ? 67.763 -19.756 23.664 1.00 26.52 ? 138 ASN A CB 1 ATOM 746 C CG . ASN A 1 110 ? 68.414 -18.655 24.450 0.010 26.61 ? 138 ASN A CG 1 ATOM 747 O OD1 . ASN A 1 110 ? 68.578 -17.541 23.959 0.010 26.49 ? 138 ASN A OD1 1 ATOM 748 N ND2 . ASN A 1 110 ? 68.781 -18.953 25.690 0.010 26.46 ? 138 ASN A ND2 1 ATOM 749 N N . ASP A 1 111 ? 70.941 -19.722 22.794 1.00 27.84 ? 139 ASP A N 1 ATOM 750 C CA . ASP A 1 111 ? 72.277 -19.930 23.381 1.00 28.76 ? 139 ASP A CA 1 ATOM 751 C C . ASP A 1 111 ? 72.924 -21.236 22.857 1.00 29.00 ? 139 ASP A C 1 ATOM 752 O O . ASP A 1 111 ? 73.369 -22.078 23.631 1.00 29.69 ? 139 ASP A O 1 ATOM 753 C CB . ASP A 1 111 ? 72.209 -19.858 24.936 1.00 27.94 ? 139 ASP A CB 1 ATOM 754 C CG . ASP A 1 111 ? 72.089 -18.445 25.454 0.010 28.35 ? 139 ASP A CG 1 ATOM 755 O OD1 . ASP A 1 111 ? 71.568 -17.570 24.729 0.010 28.13 ? 139 ASP A OD1 1 ATOM 756 O OD2 . ASP A 1 111 ? 72.511 -18.205 26.604 0.010 28.16 ? 139 ASP A OD2 1 ATOM 757 N N . GLY A 1 112 ? 72.927 -21.402 21.534 1.00 29.28 ? 140 GLY A N 1 ATOM 758 C CA . GLY A 1 112 ? 73.566 -22.547 20.874 1.00 28.98 ? 140 GLY A CA 1 ATOM 759 C C . GLY A 1 112 ? 72.909 -23.914 21.064 1.00 28.78 ? 140 GLY A C 1 ATOM 760 O O . GLY A 1 112 ? 73.552 -24.944 20.840 1.00 28.53 ? 140 GLY A O 1 ATOM 761 N N . LYS A 1 113 ? 71.639 -23.932 21.474 1.00 28.37 ? 141 LYS A N 1 ATOM 762 C CA . LYS A 1 113 ? 70.902 -25.188 21.685 1.00 28.12 ? 141 LYS A CA 1 ATOM 763 C C . LYS A 1 113 ? 69.506 -25.186 21.070 1.00 27.58 ? 141 LYS A C 1 ATOM 764 O O . LYS A 1 113 ? 68.774 -24.182 21.159 1.00 28.04 ? 141 LYS A O 1 ATOM 765 C CB . LYS A 1 113 ? 70.772 -25.493 23.169 1.00 28.57 ? 141 LYS A CB 1 ATOM 766 C CG . LYS A 1 113 ? 72.076 -25.907 23.794 1.00 31.92 ? 141 LYS A CG 1 ATOM 767 C CD . LYS A 1 113 ? 71.956 -26.238 25.268 1.00 36.55 ? 141 LYS A CD 1 ATOM 768 C CE . LYS A 1 113 ? 73.376 -26.368 25.848 1.00 39.50 ? 141 LYS A CE 1 ATOM 769 N NZ . LYS A 1 113 ? 73.420 -27.262 27.038 1.00 41.34 ? 141 LYS A NZ 1 ATOM 770 N N . ILE A 1 114 ? 69.134 -26.309 20.455 1.00 26.07 ? 142 ILE A N 1 ATOM 771 C CA . ILE A 1 114 ? 67.792 -26.487 19.917 1.00 24.35 ? 142 ILE A CA 1 ATOM 772 C C . ILE A 1 114 ? 67.136 -27.683 20.596 1.00 24.08 ? 142 ILE A C 1 ATOM 773 O O . ILE A 1 114 ? 67.666 -28.785 20.553 1.00 24.55 ? 142 ILE A O 1 ATOM 774 C CB . ILE A 1 114 ? 67.828 -26.724 18.393 1.00 24.07 ? 142 ILE A CB 1 ATOM 775 C CG1 . ILE A 1 114 ? 68.504 -25.547 17.688 1.00 22.73 ? 142 ILE A CG1 1 ATOM 776 C CG2 . ILE A 1 114 ? 66.408 -26.962 17.849 1.00 22.50 ? 142 ILE A CG2 1 ATOM 777 C CD1 . ILE A 1 114 ? 69.536 -25.965 16.658 1.00 21.79 ? 142 ILE A CD1 1 ATOM 778 N N . ALA A 1 115 ? 65.966 -27.480 21.183 1.00 23.46 ? 143 ALA A N 1 ATOM 779 C CA . ALA A 1 115 ? 65.258 -28.554 21.872 1.00 23.17 ? 143 ALA A CA 1 ATOM 780 C C . ALA A 1 115 ? 63.894 -28.790 21.260 1.00 22.86 ? 143 ALA A C 1 ATOM 781 O O . ALA A 1 115 ? 63.127 -27.854 21.092 1.00 23.62 ? 143 ALA A O 1 ATOM 782 C CB . ALA A 1 115 ? 65.108 -28.218 23.339 1.00 23.28 ? 143 ALA A CB 1 ATOM 783 N N . ILE A 1 116 ? 63.582 -30.033 20.928 1.00 22.26 ? 144 ILE A N 1 ATOM 784 C CA . ILE A 1 116 ? 62.251 -30.362 20.430 1.00 21.52 ? 144 ILE A CA 1 ATOM 785 C C . ILE A 1 116 ? 61.593 -31.396 21.334 1.00 21.36 ? 144 ILE A C 1 ATOM 786 O O . ILE A 1 116 ? 62.141 -32.485 21.554 1.00 21.68 ? 144 ILE A O 1 ATOM 787 C CB . ILE A 1 116 ? 62.289 -30.875 18.965 1.00 21.46 ? 144 ILE A CB 1 ATOM 788 C CG1 . ILE A 1 116 ? 62.844 -29.802 18.028 1.00 21.10 ? 144 ILE A CG1 1 ATOM 789 C CG2 . ILE A 1 116 ? 60.883 -31.267 18.496 1.00 21.05 ? 144 ILE A CG2 1 ATOM 790 C CD1 . ILE A 1 116 ? 63.376 -30.349 16.709 1.00 19.47 ? 144 ILE A CD1 1 ATOM 791 N N . GLU A 1 117 ? 60.426 -31.058 21.866 1.00 20.97 ? 145 GLU A N 1 ATOM 792 C CA . GLU A 1 117 ? 59.656 -31.996 22.671 1.00 20.77 ? 145 GLU A CA 1 ATOM 793 C C . GLU A 1 117 ? 58.266 -32.151 22.097 1.00 20.43 ? 145 GLU A C 1 ATOM 794 O O . GLU A 1 117 ? 57.490 -31.193 22.076 1.00 19.96 ? 145 GLU A O 1 ATOM 795 C CB . GLU A 1 117 ? 59.564 -31.555 24.136 1.00 20.76 ? 145 GLU A CB 1 ATOM 796 C CG . GLU A 1 117 ? 58.998 -32.648 25.050 1.00 22.85 ? 145 GLU A CG 1 ATOM 797 C CD . GLU A 1 117 ? 58.711 -32.190 26.488 1.00 26.53 ? 145 GLU A CD 1 ATOM 798 O OE1 . GLU A 1 117 ? 58.005 -31.182 26.676 1.00 28.46 ? 145 GLU A OE1 1 ATOM 799 O OE2 . GLU A 1 117 ? 59.169 -32.861 27.440 1.00 29.18 ? 145 GLU A OE2 1 ATOM 800 N N . GLY A 1 118 ? 57.956 -33.352 21.619 1.00 20.41 ? 146 GLY A N 1 ATOM 801 C CA . GLY A 1 118 ? 56.614 -33.634 21.123 1.00 20.88 ? 146 GLY A CA 1 ATOM 802 C C . GLY A 1 118 ? 55.688 -34.120 22.226 1.00 21.22 ? 146 GLY A C 1 ATOM 803 O O . GLY A 1 118 ? 56.108 -34.881 23.096 1.00 21.23 ? 146 GLY A O 1 ATOM 804 N N . LYS A 1 119 ? 54.430 -33.687 22.188 1.00 21.27 ? 147 LYS A N 1 ATOM 805 C CA . LYS A 1 119 ? 53.386 -34.292 23.006 1.00 21.92 ? 147 LYS A CA 1 ATOM 806 C C . LYS A 1 119 ? 53.323 -35.793 22.758 1.00 22.00 ? 147 LYS A C 1 ATOM 807 O O . LYS A 1 119 ? 53.129 -36.564 23.680 1.00 22.59 ? 147 LYS A O 1 ATOM 808 C CB . LYS A 1 119 ? 52.013 -33.685 22.697 1.00 22.64 ? 147 LYS A CB 1 ATOM 809 C CG . LYS A 1 119 ? 50.839 -34.400 23.380 1.00 22.90 ? 147 LYS A CG 1 ATOM 810 C CD . LYS A 1 119 ? 51.025 -34.364 24.907 1.00 23.77 ? 147 LYS A CD 1 ATOM 811 C CE . LYS A 1 119 ? 49.838 -34.934 25.630 1.00 25.01 ? 147 LYS A CE 1 ATOM 812 N NZ . LYS A 1 119 ? 49.989 -34.681 27.105 1.00 28.88 ? 147 LYS A NZ 1 ATOM 813 N N . ASP A 1 120 ? 53.484 -36.191 21.503 1.00 21.72 ? 148 ASP A N 1 ATOM 814 C CA . ASP A 1 120 ? 53.650 -37.585 21.125 1.00 21.36 ? 148 ASP A CA 1 ATOM 815 C C . ASP A 1 120 ? 54.660 -37.584 19.994 1.00 20.99 ? 148 ASP A C 1 ATOM 816 O O . ASP A 1 120 ? 55.222 -36.535 19.684 1.00 20.88 ? 148 ASP A O 1 ATOM 817 C CB . ASP A 1 120 ? 52.314 -38.195 20.677 1.00 21.05 ? 148 ASP A CB 1 ATOM 818 C CG . ASP A 1 120 ? 51.510 -37.259 19.778 1.00 22.96 ? 148 ASP A CG 1 ATOM 819 O OD1 . ASP A 1 120 ? 52.113 -36.635 18.864 1.00 23.39 ? 148 ASP A OD1 1 ATOM 820 O OD2 . ASP A 1 120 ? 50.272 -37.128 19.992 1.00 23.99 ? 148 ASP A OD2 1 ATOM 821 N N . GLY A 1 121 ? 54.877 -38.744 19.379 1.00 20.59 ? 149 GLY A N 1 ATOM 822 C CA . GLY A 1 121 ? 55.738 -38.869 18.210 1.00 20.34 ? 149 GLY A CA 1 ATOM 823 C C . GLY A 1 121 ? 55.321 -38.073 16.975 1.00 20.48 ? 149 GLY A C 1 ATOM 824 O O . GLY A 1 121 ? 56.164 -37.419 16.344 1.00 21.03 ? 149 GLY A O 1 ATOM 825 N N . ASP A 1 122 ? 54.042 -38.134 16.612 1.00 20.30 ? 150 ASP A N 1 ATOM 826 C CA . ASP A 1 122 ? 53.502 -37.279 15.552 1.00 20.97 ? 150 ASP A CA 1 ATOM 827 C C . ASP A 1 122 ? 54.019 -35.832 15.832 1.00 20.26 ? 150 ASP A C 1 ATOM 828 O O . ASP A 1 122 ? 54.619 -35.159 14.970 1.00 19.74 ? 150 ASP A O 1 ATOM 829 C CB . ASP A 1 122 ? 51.947 -37.328 15.503 1.00 21.38 ? 150 ASP A CB 1 ATOM 830 C CG . ASP A 1 122 ? 51.360 -38.738 15.129 1.00 25.23 ? 150 ASP A CG 1 ATOM 831 O OD1 . ASP A 1 122 ? 52.085 -39.658 14.661 1.00 30.12 ? 150 ASP A OD1 1 ATOM 832 O OD2 . ASP A 1 122 ? 50.124 -38.924 15.285 1.00 29.57 ? 150 ASP A OD2 1 ATOM 833 N N . GLY A 1 123 ? 53.843 -35.397 17.077 1.00 19.74 ? 151 GLY A N 1 ATOM 834 C CA . GLY A 1 123 ? 54.309 -34.088 17.532 1.00 18.95 ? 151 GLY A CA 1 ATOM 835 C C . GLY A 1 123 ? 55.800 -33.852 17.378 1.00 18.91 ? 151 GLY A C 1 ATOM 836 O O . GLY A 1 123 ? 56.209 -32.760 16.944 1.00 19.36 ? 151 GLY A O 1 ATOM 837 N N . THR A 1 124 ? 56.620 -34.850 17.721 1.00 17.70 ? 152 THR A N 1 ATOM 838 C CA . THR A 1 124 ? 58.064 -34.714 17.552 1.00 17.31 ? 152 THR A CA 1 ATOM 839 C C . THR A 1 124 ? 58.446 -34.546 16.072 1.00 17.18 ? 152 THR A C 1 ATOM 840 O O . THR A 1 124 ? 59.298 -33.711 15.723 1.00 17.05 ? 152 THR A O 1 ATOM 841 C CB . THR A 1 124 ? 58.845 -35.910 18.136 1.00 17.61 ? 152 THR A CB 1 ATOM 842 O OG1 . THR A 1 124 ? 58.299 -36.293 19.403 1.00 18.54 ? 152 THR A OG1 1 ATOM 843 C CG2 . THR A 1 124 ? 60.286 -35.546 18.330 1.00 16.27 ? 152 THR A CG2 1 ATOM 844 N N . PHE A 1 125 ? 57.822 -35.350 15.210 1.00 16.53 ? 153 PHE A N 1 ATOM 845 C CA . PHE A 1 125 ? 58.033 -35.251 13.764 1.00 16.15 ? 153 PHE A CA 1 ATOM 846 C C . PHE A 1 125 ? 57.690 -33.826 13.278 1.00 16.20 ? 153 PHE A C 1 ATOM 847 O O . PHE A 1 125 ? 58.472 -33.205 12.535 1.00 17.16 ? 153 PHE A O 1 ATOM 848 C CB . PHE A 1 125 ? 57.204 -36.324 13.044 1.00 15.25 ? 153 PHE A CB 1 ATOM 849 C CG . PHE A 1 125 ? 57.285 -36.270 11.547 1.00 14.19 ? 153 PHE A CG 1 ATOM 850 C CD1 . PHE A 1 125 ? 58.277 -36.981 10.861 1.00 12.44 ? 153 PHE A CD1 1 ATOM 851 C CD2 . PHE A 1 125 ? 56.341 -35.549 10.808 1.00 13.89 ? 153 PHE A CD2 1 ATOM 852 C CE1 . PHE A 1 125 ? 58.343 -36.963 9.466 1.00 10.32 ? 153 PHE A CE1 1 ATOM 853 C CE2 . PHE A 1 125 ? 56.405 -35.510 9.399 1.00 11.90 ? 153 PHE A CE2 1 ATOM 854 C CZ . PHE A 1 125 ? 57.408 -36.224 8.732 1.00 11.39 ? 153 PHE A CZ 1 ATOM 855 N N . TYR A 1 126 ? 56.547 -33.306 13.724 1.00 15.53 ? 154 TYR A N 1 ATOM 856 C CA . TYR A 1 126 ? 56.108 -31.970 13.322 1.00 15.41 ? 154 TYR A CA 1 ATOM 857 C C . TYR A 1 126 ? 57.056 -30.896 13.854 1.00 15.13 ? 154 TYR A C 1 ATOM 858 O O . TYR A 1 126 ? 57.376 -29.973 13.127 1.00 14.83 ? 154 TYR A O 1 ATOM 859 C CB . TYR A 1 126 ? 54.615 -31.700 13.696 1.00 15.60 ? 154 TYR A CB 1 ATOM 860 C CG . TYR A 1 126 ? 53.635 -32.628 12.989 1.00 14.62 ? 154 TYR A CG 1 ATOM 861 C CD1 . TYR A 1 126 ? 53.912 -33.123 11.708 1.00 13.31 ? 154 TYR A CD1 1 ATOM 862 C CD2 . TYR A 1 126 ? 52.454 -33.046 13.616 1.00 15.06 ? 154 TYR A CD2 1 ATOM 863 C CE1 . TYR A 1 126 ? 53.051 -33.998 11.071 1.00 13.04 ? 154 TYR A CE1 1 ATOM 864 C CE2 . TYR A 1 126 ? 51.557 -33.924 12.968 1.00 13.36 ? 154 TYR A CE2 1 ATOM 865 C CZ . TYR A 1 126 ? 51.874 -34.384 11.693 1.00 14.38 ? 154 TYR A CZ 1 ATOM 866 O OH . TYR A 1 126 ? 51.027 -35.256 11.041 1.00 16.71 ? 154 TYR A OH 1 ATOM 867 N N . GLY A 1 127 ? 57.539 -31.054 15.093 1.00 15.31 ? 155 GLY A N 1 ATOM 868 C CA . GLY A 1 127 ? 58.603 -30.210 15.649 1.00 15.21 ? 155 GLY A CA 1 ATOM 869 C C . GLY A 1 127 ? 59.832 -30.132 14.748 1.00 15.83 ? 155 GLY A C 1 ATOM 870 O O . GLY A 1 127 ? 60.374 -29.032 14.507 1.00 16.06 ? 155 GLY A O 1 ATOM 871 N N . VAL A 1 128 ? 60.262 -31.283 14.221 1.00 15.55 ? 156 VAL A N 1 ATOM 872 C CA . VAL A 1 128 ? 61.360 -31.312 13.254 1.00 15.34 ? 156 VAL A CA 1 ATOM 873 C C . VAL A 1 128 ? 61.003 -30.583 11.952 1.00 15.76 ? 156 VAL A C 1 ATOM 874 O O . VAL A 1 128 ? 61.852 -29.919 11.348 1.00 15.66 ? 156 VAL A O 1 ATOM 875 C CB . VAL A 1 128 ? 61.810 -32.743 12.932 1.00 15.45 ? 156 VAL A CB 1 ATOM 876 C CG1 . VAL A 1 128 ? 62.787 -32.764 11.768 1.00 13.52 ? 156 VAL A CG1 1 ATOM 877 C CG2 . VAL A 1 128 ? 62.425 -33.376 14.149 1.00 14.46 ? 156 VAL A CG2 1 ATOM 878 N N . GLN A 1 129 ? 59.755 -30.696 11.514 1.00 15.87 ? 157 GLN A N 1 ATOM 879 C CA . GLN A 1 129 ? 59.365 -30.008 10.285 1.00 16.16 ? 157 GLN A CA 1 ATOM 880 C C . GLN A 1 129 ? 59.503 -28.517 10.450 1.00 16.62 ? 157 GLN A C 1 ATOM 881 O O . GLN A 1 129 ? 59.958 -27.849 9.524 1.00 17.96 ? 157 GLN A O 1 ATOM 882 C CB . GLN A 1 129 ? 57.950 -30.353 9.820 1.00 15.65 ? 157 GLN A CB 1 ATOM 883 C CG . GLN A 1 129 ? 57.716 -31.811 9.590 1.00 15.44 ? 157 GLN A CG 1 ATOM 884 C CD . GLN A 1 129 ? 58.726 -32.431 8.641 1.00 17.28 ? 157 GLN A CD 1 ATOM 885 O OE1 . GLN A 1 129 ? 59.092 -31.856 7.597 1.00 17.25 ? 157 GLN A OE1 1 ATOM 886 N NE2 . GLN A 1 129 ? 59.177 -33.624 8.993 1.00 15.76 ? 157 GLN A NE2 1 ATOM 887 N N . THR A 1 130 ? 59.118 -27.987 11.608 1.00 16.52 ? 158 THR A N 1 ATOM 888 C CA . THR A 1 130 ? 59.243 -26.549 11.863 1.00 16.14 ? 158 THR A CA 1 ATOM 889 C C . THR A 1 130 ? 60.710 -26.162 11.957 1.00 17.37 ? 158 THR A C 1 ATOM 890 O O . THR A 1 130 ? 61.112 -25.146 11.412 1.00 18.27 ? 158 THR A O 1 ATOM 891 C CB . THR A 1 130 ? 58.507 -26.128 13.143 1.00 15.74 ? 158 THR A CB 1 ATOM 892 O OG1 . THR A 1 130 ? 57.142 -26.520 13.040 1.00 12.37 ? 158 THR A OG1 1 ATOM 893 C CG2 . THR A 1 130 ? 58.574 -24.627 13.336 1.00 14.27 ? 158 THR A CG2 1 ATOM 894 N N . PHE A 1 131 ? 61.506 -26.971 12.650 1.00 18.37 ? 159 PHE A N 1 ATOM 895 C CA . PHE A 1 131 ? 62.960 -26.809 12.644 1.00 19.21 ? 159 PHE A CA 1 ATOM 896 C C . PHE A 1 131 ? 63.522 -26.724 11.222 1.00 19.81 ? 159 PHE A C 1 ATOM 897 O O . PHE A 1 131 ? 64.324 -25.839 10.929 1.00 20.57 ? 159 PHE A O 1 ATOM 898 C CB . PHE A 1 131 ? 63.623 -27.957 13.387 1.00 19.17 ? 159 PHE A CB 1 ATOM 899 C CG . PHE A 1 131 ? 65.113 -27.980 13.266 1.00 19.46 ? 159 PHE A CG 1 ATOM 900 C CD1 . PHE A 1 131 ? 65.905 -27.144 14.065 1.00 19.43 ? 159 PHE A CD1 1 ATOM 901 C CD2 . PHE A 1 131 ? 65.730 -28.855 12.375 1.00 19.04 ? 159 PHE A CD2 1 ATOM 902 C CE1 . PHE A 1 131 ? 67.292 -27.174 13.968 1.00 19.90 ? 159 PHE A CE1 1 ATOM 903 C CE2 . PHE A 1 131 ? 67.109 -28.892 12.253 1.00 18.96 ? 159 PHE A CE2 1 ATOM 904 C CZ . PHE A 1 131 ? 67.902 -28.059 13.055 1.00 20.33 ? 159 PHE A CZ 1 ATOM 905 N N . LYS A 1 132 ? 63.105 -27.634 10.343 1.00 20.28 ? 160 LYS A N 1 ATOM 906 C CA . LYS A 1 132 ? 63.573 -27.636 8.949 1.00 20.64 ? 160 LYS A CA 1 ATOM 907 C C . LYS A 1 132 ? 63.239 -26.326 8.225 1.00 20.72 ? 160 LYS A C 1 ATOM 908 O O . LYS A 1 132 ? 64.008 -25.858 7.409 1.00 21.09 ? 160 LYS A O 1 ATOM 909 C CB . LYS A 1 132 ? 63.010 -28.832 8.181 1.00 20.33 ? 160 LYS A CB 1 ATOM 910 C CG . LYS A 1 132 ? 63.684 -30.199 8.524 1.00 21.01 ? 160 LYS A CG 1 ATOM 911 C CD . LYS A 1 132 ? 62.934 -31.377 7.904 1.00 20.62 ? 160 LYS A CD 1 ATOM 912 C CE . LYS A 1 132 ? 62.592 -31.119 6.441 1.00 21.22 ? 160 LYS A CE 1 ATOM 913 N NZ . LYS A 1 132 ? 61.563 -32.055 5.894 1.00 21.55 ? 160 LYS A NZ 1 ATOM 914 N N . GLN A 1 133 ? 62.106 -25.726 8.552 1.00 20.64 ? 161 GLN A N 1 ATOM 915 C CA . GLN A 1 133 ? 61.677 -24.506 7.905 1.00 20.86 ? 161 GLN A CA 1 ATOM 916 C C . GLN A 1 133 ? 62.409 -23.270 8.443 1.00 21.80 ? 161 GLN A C 1 ATOM 917 O O . GLN A 1 133 ? 62.647 -22.314 7.695 1.00 21.71 ? 161 GLN A O 1 ATOM 918 C CB . GLN A 1 133 ? 60.173 -24.344 8.076 1.00 20.79 ? 161 GLN A CB 1 ATOM 919 C CG . GLN A 1 133 ? 59.346 -25.385 7.319 1.00 20.10 ? 161 GLN A CG 1 ATOM 920 C CD . GLN A 1 133 ? 57.870 -25.033 7.253 1.00 19.34 ? 161 GLN A CD 1 ATOM 921 O OE1 . GLN A 1 133 ? 57.391 -24.158 7.974 1.00 21.52 ? 161 GLN A OE1 1 ATOM 922 N NE2 . GLN A 1 133 ? 57.144 -25.712 6.389 1.00 17.93 ? 161 GLN A NE2 1 ATOM 923 N N . LEU A 1 134 ? 62.760 -23.296 9.735 1.00 22.51 ? 162 LEU A N 1 ATOM 924 C CA . LEU A 1 134 ? 63.493 -22.203 10.400 1.00 23.11 ? 162 LEU A CA 1 ATOM 925 C C . LEU A 1 134 ? 64.954 -22.043 9.990 1.00 23.77 ? 162 LEU A C 1 ATOM 926 O O . LEU A 1 134 ? 65.483 -20.960 10.096 1.00 24.08 ? 162 LEU A O 1 ATOM 927 C CB . LEU A 1 134 ? 63.467 -22.375 11.915 1.00 22.93 ? 162 LEU A CB 1 ATOM 928 C CG . LEU A 1 134 ? 62.163 -22.207 12.689 1.00 22.30 ? 162 LEU A CG 1 ATOM 929 C CD1 . LEU A 1 134 ? 62.334 -22.787 14.101 1.00 20.56 ? 162 LEU A CD1 1 ATOM 930 C CD2 . LEU A 1 134 ? 61.761 -20.753 12.747 1.00 19.99 ? 162 LEU A CD2 1 ATOM 931 N N . VAL A 1 135 ? 65.618 -23.105 9.548 1.00 24.75 ? 163 VAL A N 1 ATOM 932 C CA . VAL A 1 135 ? 67.035 -22.993 9.201 1.00 25.60 ? 163 VAL A CA 1 ATOM 933 C C . VAL A 1 135 ? 67.263 -22.547 7.758 1.00 27.33 ? 163 VAL A C 1 ATOM 934 O O . VAL A 1 135 ? 66.750 -23.161 6.820 1.00 27.59 ? 163 VAL A O 1 ATOM 935 C CB . VAL A 1 135 ? 67.800 -24.274 9.508 1.00 25.15 ? 163 VAL A CB 1 ATOM 936 C CG1 . VAL A 1 135 ? 69.269 -24.116 9.155 1.00 24.48 ? 163 VAL A CG1 1 ATOM 937 C CG2 . VAL A 1 135 ? 67.652 -24.606 10.977 1.00 24.43 ? 163 VAL A CG2 1 ATOM 938 N N . LYS A 1 136 ? 68.002 -21.444 7.608 1.00 29.40 ? 164 LYS A N 1 ATOM 939 C CA . LYS A 1 136 ? 68.454 -20.941 6.309 1.00 31.59 ? 164 LYS A CA 1 ATOM 940 C C . LYS A 1 136 ? 69.963 -20.781 6.329 1.00 32.19 ? 164 LYS A C 1 ATOM 941 O O . LYS A 1 136 ? 70.488 -20.032 7.144 1.00 32.85 ? 164 LYS A O 1 ATOM 942 C CB . LYS A 1 136 ? 67.806 -19.599 5.964 1.00 31.81 ? 164 LYS A CB 1 ATOM 943 C CG . LYS A 1 136 ? 66.309 -19.679 5.624 1.00 35.72 ? 164 LYS A CG 1 ATOM 944 C CD . LYS A 1 136 ? 66.041 -20.154 4.180 1.00 41.00 ? 164 LYS A CD 1 ATOM 945 C CE . LYS A 1 136 ? 64.536 -20.113 3.852 1.00 43.13 ? 164 LYS A CE 1 ATOM 946 N NZ . LYS A 1 136 ? 63.757 -21.153 4.630 1.00 42.08 ? 164 LYS A NZ 1 ATOM 947 N N . GLU A 1 137 ? 70.651 -21.491 5.435 1.00 33.12 ? 165 GLU A N 1 ATOM 948 C CA . GLU A 1 137 ? 72.103 -21.409 5.310 1.00 34.20 ? 165 GLU A CA 1 ATOM 949 C C . GLU A 1 137 ? 72.774 -21.542 6.682 1.00 33.41 ? 165 GLU A C 1 ATOM 950 O O . GLU A 1 137 ? 73.685 -20.784 7.025 1.00 33.95 ? 165 GLU A O 1 ATOM 951 C CB . GLU A 1 137 ? 72.507 -20.111 4.593 1.00 35.13 ? 165 GLU A CB 1 ATOM 952 C CG . GLU A 1 137 ? 72.119 -20.063 3.081 1.00 40.71 ? 165 GLU A CG 1 ATOM 953 C CD . GLU A 1 137 ? 72.330 -18.668 2.429 1.00 48.39 ? 165 GLU A CD 1 ATOM 954 O OE1 . GLU A 1 137 ? 72.668 -17.694 3.153 1.00 51.60 ? 165 GLU A OE1 1 ATOM 955 O OE2 . GLU A 1 137 ? 72.158 -18.539 1.185 1.00 50.02 ? 165 GLU A OE2 1 ATOM 956 N N . SER A 1 138 ? 72.276 -22.498 7.465 1.00 32.18 ? 166 SER A N 1 ATOM 957 C CA . SER A 1 138 ? 72.779 -22.808 8.794 1.00 30.78 ? 166 SER A CA 1 ATOM 958 C C . SER A 1 138 ? 72.397 -21.862 9.917 1.00 29.68 ? 166 SER A C 1 ATOM 959 O O . SER A 1 138 ? 72.669 -22.142 11.089 1.00 29.44 ? 166 SER A O 1 ATOM 960 C CB . SER A 1 138 ? 74.277 -22.998 8.760 1.00 31.23 ? 166 SER A CB 1 ATOM 961 O OG . SER A 1 138 ? 74.557 -24.355 8.503 1.00 33.87 ? 166 SER A OG 1 ATOM 962 N N . ASN A 1 139 ? 71.771 -20.748 9.563 1.00 28.24 ? 167 ASN A N 1 ATOM 963 C CA . ASN A 1 139 ? 71.338 -19.765 10.539 1.00 27.31 ? 167 ASN A CA 1 ATOM 964 C C . ASN A 1 139 ? 69.945 -20.087 11.055 1.00 26.51 ? 167 ASN A C 1 ATOM 965 O O . ASN A 1 139 ? 69.066 -20.461 10.264 1.00 26.13 ? 167 ASN A O 1 ATOM 966 C CB . ASN A 1 139 ? 71.373 -18.359 9.927 1.00 27.76 ? 167 ASN A CB 1 ATOM 967 C CG . ASN A 1 139 ? 72.795 -17.860 9.699 1.00 29.23 ? 167 ASN A CG 1 ATOM 968 O OD1 . ASN A 1 139 ? 73.572 -17.718 10.643 1.00 33.20 ? 167 ASN A OD1 1 ATOM 969 N ND2 . ASN A 1 139 ? 73.146 -17.613 8.447 1.00 29.11 ? 167 ASN A ND2 1 ATOM 970 N N . ILE A 1 140 ? 69.747 -19.939 12.369 1.00 24.84 ? 168 ILE A N 1 ATOM 971 C CA . ILE A 1 140 ? 68.455 -20.214 12.980 1.00 23.50 ? 168 ILE A CA 1 ATOM 972 C C . ILE A 1 140 ? 68.017 -19.066 13.911 1.00 23.38 ? 168 ILE A C 1 ATOM 973 O O . ILE A 1 140 ? 68.822 -18.556 14.681 1.00 23.69 ? 168 ILE A O 1 ATOM 974 C CB . ILE A 1 140 ? 68.448 -21.614 13.697 1.00 23.15 ? 168 ILE A CB 1 ATOM 975 C CG1 . ILE A 1 140 ? 67.024 -22.123 13.865 1.00 22.30 ? 168 ILE A CG1 1 ATOM 976 C CG2 . ILE A 1 140 ? 69.207 -21.604 15.031 1.00 21.65 ? 168 ILE A CG2 1 ATOM 977 C CD1 . ILE A 1 140 ? 66.923 -23.398 14.658 1.00 21.92 ? 168 ILE A CD1 1 ATOM 978 N N . PRO A 1 141 ? 66.747 -18.633 13.833 1.00 22.97 ? 169 PRO A N 1 ATOM 979 C CA . PRO A 1 141 ? 66.374 -17.639 14.826 1.00 22.81 ? 169 PRO A CA 1 ATOM 980 C C . PRO A 1 141 ? 66.299 -18.274 16.198 1.00 23.38 ? 169 PRO A C 1 ATOM 981 O O . PRO A 1 141 ? 66.170 -19.505 16.307 1.00 24.34 ? 169 PRO A O 1 ATOM 982 C CB . PRO A 1 141 ? 64.978 -17.187 14.384 1.00 22.82 ? 169 PRO A CB 1 ATOM 983 C CG . PRO A 1 141 ? 64.529 -18.158 13.382 1.00 22.91 ? 169 PRO A CG 1 ATOM 984 C CD . PRO A 1 141 ? 65.740 -18.760 12.767 1.00 22.73 ? 169 PRO A CD 1 ATOM 985 N N . GLU A 1 142 ? 66.388 -17.456 17.241 1.00 22.82 ? 170 GLU A N 1 ATOM 986 C CA . GLU A 1 142 ? 66.222 -17.950 18.589 1.00 22.24 ? 170 GLU A CA 1 ATOM 987 C C . GLU A 1 142 ? 64.791 -17.691 19.008 1.00 21.64 ? 170 GLU A C 1 ATOM 988 O O . GLU A 1 142 ? 64.387 -16.537 19.146 1.00 21.75 ? 170 GLU A O 1 ATOM 989 C CB . GLU A 1 142 ? 67.218 -17.272 19.533 1.00 22.63 ? 170 GLU A CB 1 ATOM 990 C CG . GLU A 1 142 ? 68.625 -17.834 19.402 1.00 24.19 ? 170 GLU A CG 1 ATOM 991 C CD . GLU A 1 142 ? 69.672 -17.035 20.152 1.00 25.73 ? 170 GLU A CD 1 ATOM 992 O OE1 . GLU A 1 142 ? 69.760 -15.811 19.972 1.00 25.72 ? 170 GLU A OE1 1 ATOM 993 O OE2 . GLU A 1 142 ? 70.427 -17.632 20.935 1.00 27.83 ? 170 GLU A OE2 1 ATOM 994 N N . VAL A 1 143 ? 64.023 -18.768 19.185 1.00 20.48 ? 171 VAL A N 1 ATOM 995 C CA . VAL A 1 143 ? 62.588 -18.670 19.396 1.00 19.36 ? 171 VAL A CA 1 ATOM 996 C C . VAL A 1 143 ? 62.073 -19.634 20.495 1.00 19.67 ? 171 VAL A C 1 ATOM 997 O O . VAL A 1 143 ? 62.722 -20.618 20.806 1.00 19.56 ? 171 VAL A O 1 ATOM 998 C CB . VAL A 1 143 ? 61.827 -18.900 18.066 1.00 19.27 ? 171 VAL A CB 1 ATOM 999 C CG1 . VAL A 1 143 ? 62.277 -17.905 17.003 1.00 19.03 ? 171 VAL A CG1 1 ATOM 1000 C CG2 . VAL A 1 143 ? 62.024 -20.304 17.564 1.00 18.35 ? 171 VAL A CG2 1 ATOM 1001 N N . ASN A 1 144 ? 60.933 -19.320 21.110 1.00 19.63 ? 172 ASN A N 1 ATOM 1002 C CA . ASN A 1 144 ? 60.257 -20.235 22.012 1.00 20.16 ? 172 ASN A CA 1 ATOM 1003 C C . ASN A 1 144 ? 58.920 -20.511 21.355 1.00 20.16 ? 172 ASN A C 1 ATOM 1004 O O . ASN A 1 144 ? 58.146 -19.601 21.144 1.00 21.24 ? 172 ASN A O 1 ATOM 1005 C CB . ASN A 1 144 ? 60.098 -19.672 23.454 1.00 19.77 ? 172 ASN A CB 1 ATOM 1006 C CG . ASN A 1 144 ? 59.539 -20.689 24.421 0.010 19.90 ? 172 ASN A CG 1 ATOM 1007 O OD1 . ASN A 1 144 ? 58.373 -21.080 24.338 0.010 19.76 ? 172 ASN A OD1 1 ATOM 1008 N ND2 . ASN A 1 144 ? 60.369 -21.111 25.362 0.010 19.79 ? 172 ASN A ND2 1 ATOM 1009 N N . ILE A 1 145 ? 58.664 -21.767 21.006 1.00 20.13 ? 173 ILE A N 1 ATOM 1010 C CA . ILE A 1 145 ? 57.444 -22.155 20.309 1.00 19.83 ? 173 ILE A CA 1 ATOM 1011 C C . ILE A 1 145 ? 56.735 -23.249 21.078 1.00 19.71 ? 173 ILE A C 1 ATOM 1012 O O . ILE A 1 145 ? 57.366 -24.201 21.553 1.00 20.30 ? 173 ILE A O 1 ATOM 1013 C CB . ILE A 1 145 ? 57.761 -22.726 18.902 1.00 20.04 ? 173 ILE A CB 1 ATOM 1014 C CG1 . ILE A 1 145 ? 58.205 -21.621 17.955 1.00 20.01 ? 173 ILE A CG1 1 ATOM 1015 C CG2 . ILE A 1 145 ? 56.563 -23.472 18.307 1.00 20.22 ? 173 ILE A CG2 1 ATOM 1016 C CD1 . ILE A 1 145 ? 58.793 -22.149 16.680 1.00 19.47 ? 173 ILE A CD1 1 ATOM 1017 N N . THR A 1 146 ? 55.426 -23.098 21.215 1.00 19.26 ? 174 THR A N 1 ATOM 1018 C CA . THR A 1 146 ? 54.555 -24.217 21.513 1.00 19.11 ? 174 THR A CA 1 ATOM 1019 C C . THR A 1 146 ? 53.526 -24.205 20.407 1.00 18.98 ? 174 THR A C 1 ATOM 1020 O O . THR A 1 146 ? 53.020 -23.151 20.026 1.00 19.11 ? 174 THR A O 1 ATOM 1021 C CB . THR A 1 146 ? 53.884 -24.165 22.943 1.00 19.18 ? 174 THR A CB 1 ATOM 1022 O OG1 . THR A 1 146 ? 53.200 -22.926 23.132 1.00 20.04 ? 174 THR A OG1 1 ATOM 1023 C CG2 . THR A 1 146 ? 54.915 -24.345 24.042 1.00 17.45 ? 174 THR A CG2 1 ATOM 1024 N N . ASP A 1 147 ? 53.235 -25.377 19.873 1.00 18.84 ? 175 ASP A N 1 ATOM 1025 C CA . ASP A 1 147 ? 52.434 -25.469 18.655 1.00 18.82 ? 175 ASP A CA 1 ATOM 1026 C C . ASP A 1 147 ? 51.598 -26.779 18.632 1.00 18.95 ? 175 ASP A C 1 ATOM 1027 O O . ASP A 1 147 ? 51.991 -27.786 19.235 1.00 19.06 ? 175 ASP A O 1 ATOM 1028 C CB . ASP A 1 147 ? 53.370 -25.324 17.450 1.00 18.18 ? 175 ASP A CB 1 ATOM 1029 C CG . ASP A 1 147 ? 52.642 -25.140 16.156 1.00 18.19 ? 175 ASP A CG 1 ATOM 1030 O OD1 . ASP A 1 147 ? 51.454 -24.750 16.177 1.00 14.13 ? 175 ASP A OD1 1 ATOM 1031 O OD2 . ASP A 1 147 ? 53.278 -25.395 15.103 1.00 18.60 ? 175 ASP A OD2 1 ATOM 1032 N N . TYR A 1 148 ? 50.431 -26.725 17.988 1.00 18.76 ? 176 TYR A N 1 ATOM 1033 C CA . TYR A 1 148 ? 49.461 -27.815 17.964 1.00 19.12 ? 176 TYR A CA 1 ATOM 1034 C C . TYR A 1 148 ? 48.364 -27.458 16.953 1.00 19.48 ? 176 TYR A C 1 ATOM 1035 O O . TYR A 1 148 ? 48.153 -26.271 16.675 1.00 19.33 ? 176 TYR A O 1 ATOM 1036 C CB . TYR A 1 148 ? 48.860 -28.055 19.361 1.00 19.36 ? 176 TYR A CB 1 ATOM 1037 C CG . TYR A 1 148 ? 48.339 -26.789 20.006 1.00 21.23 ? 176 TYR A CG 1 ATOM 1038 C CD1 . TYR A 1 148 ? 47.050 -26.318 19.722 1.00 20.40 ? 176 TYR A CD1 1 ATOM 1039 C CD2 . TYR A 1 148 ? 49.159 -26.032 20.870 1.00 22.26 ? 176 TYR A CD2 1 ATOM 1040 C CE1 . TYR A 1 148 ? 46.586 -25.132 20.277 1.00 23.97 ? 176 TYR A CE1 1 ATOM 1041 C CE2 . TYR A 1 148 ? 48.702 -24.841 21.439 1.00 23.82 ? 176 TYR A CE2 1 ATOM 1042 C CZ . TYR A 1 148 ? 47.415 -24.399 21.135 1.00 25.82 ? 176 TYR A CZ 1 ATOM 1043 O OH . TYR A 1 148 ? 46.940 -23.236 21.699 1.00 28.94 ? 176 TYR A OH 1 ATOM 1044 N N . PRO A 1 149 ? 47.667 -28.476 16.390 1.00 19.75 ? 177 PRO A N 1 ATOM 1045 C CA . PRO A 1 149 ? 46.653 -28.235 15.361 1.00 19.93 ? 177 PRO A CA 1 ATOM 1046 C C . PRO A 1 149 ? 45.287 -27.896 15.907 1.00 20.25 ? 177 PRO A C 1 ATOM 1047 O O . PRO A 1 149 ? 44.896 -28.404 16.933 1.00 21.40 ? 177 PRO A O 1 ATOM 1048 C CB . PRO A 1 149 ? 46.567 -29.578 14.651 1.00 19.62 ? 177 PRO A CB 1 ATOM 1049 C CG . PRO A 1 149 ? 46.869 -30.566 15.702 1.00 19.84 ? 177 PRO A CG 1 ATOM 1050 C CD . PRO A 1 149 ? 47.903 -29.919 16.581 1.00 19.72 ? 177 PRO A CD 1 ATOM 1051 N N . THR A 1 150 ? 44.555 -27.059 15.198 1.00 20.65 ? 178 THR A N 1 ATOM 1052 C CA . THR A 1 150 ? 43.147 -26.797 15.489 1.00 20.26 ? 178 THR A CA 1 ATOM 1053 C C . THR A 1 150 ? 42.296 -28.022 15.139 1.00 20.46 ? 178 THR A C 1 ATOM 1054 O O . THR A 1 150 ? 41.494 -28.453 15.939 1.00 20.51 ? 178 THR A O 1 ATOM 1055 C CB . THR A 1 150 ? 42.645 -25.624 14.642 1.00 19.49 ? 178 THR A CB 1 ATOM 1056 O OG1 . THR A 1 150 ? 43.546 -24.534 14.778 1.00 19.16 ? 178 THR A OG1 1 ATOM 1057 C CG2 . THR A 1 150 ? 41.294 -25.193 15.072 1.00 18.96 ? 178 THR A CG2 1 ATOM 1058 N N . VAL A 1 151 ? 42.470 -28.563 13.937 1.00 21.09 ? 179 VAL A N 1 ATOM 1059 C CA . VAL A 1 151 ? 41.681 -29.718 13.459 1.00 22.02 ? 179 VAL A CA 1 ATOM 1060 C C . VAL A 1 151 ? 42.490 -31.006 13.581 1.00 22.27 ? 179 VAL A C 1 ATOM 1061 O O . VAL A 1 151 ? 43.640 -31.069 13.146 1.00 22.31 ? 179 VAL A O 1 ATOM 1062 C CB . VAL A 1 151 ? 41.185 -29.506 11.991 1.00 21.89 ? 179 VAL A CB 1 ATOM 1063 C CG1 . VAL A 1 151 ? 40.340 -30.645 11.556 1.00 21.72 ? 179 VAL A CG1 1 ATOM 1064 C CG2 . VAL A 1 151 ? 40.362 -28.235 11.894 1.00 22.10 ? 179 VAL A CG2 1 ATOM 1065 N N . SER A 1 152 ? 41.913 -32.037 14.178 1.00 23.08 ? 180 SER A N 1 ATOM 1066 C CA . SER A 1 152 ? 42.726 -33.230 14.437 1.00 24.07 ? 180 SER A CA 1 ATOM 1067 C C . SER A 1 152 ? 43.019 -34.081 13.202 1.00 23.20 ? 180 SER A C 1 ATOM 1068 O O . SER A 1 152 ? 44.040 -34.757 13.170 1.00 24.16 ? 180 SER A O 1 ATOM 1069 C CB . SER A 1 152 ? 42.182 -34.065 15.592 1.00 24.44 ? 180 SER A CB 1 ATOM 1070 O OG . SER A 1 152 ? 40.784 -34.245 15.415 1.00 30.38 ? 180 SER A OG 1 ATOM 1071 N N . ALA A 1 153 ? 42.170 -34.043 12.180 1.00 22.17 ? 181 ALA A N 1 ATOM 1072 C CA . ALA A 1 153 ? 42.487 -34.748 10.932 1.00 21.38 ? 181 ALA A CA 1 ATOM 1073 C C . ALA A 1 153 ? 42.539 -33.747 9.777 1.00 20.98 ? 181 ALA A C 1 ATOM 1074 O O . ALA A 1 153 ? 41.583 -33.009 9.555 1.00 20.71 ? 181 ALA A O 1 ATOM 1075 C CB . ALA A 1 153 ? 41.482 -35.828 10.657 1.00 20.98 ? 181 ALA A CB 1 ATOM 1076 N N . ARG A 1 154 ? 43.659 -33.733 9.057 1.00 20.29 ? 182 ARG A N 1 ATOM 1077 C CA . ARG A 1 154 ? 43.953 -32.710 8.050 1.00 20.02 ? 182 ARG A CA 1 ATOM 1078 C C . ARG A 1 154 ? 44.614 -33.382 6.865 1.00 20.06 ? 182 ARG A C 1 ATOM 1079 O O . ARG A 1 154 ? 45.627 -34.085 7.028 1.00 21.03 ? 182 ARG A O 1 ATOM 1080 C CB . ARG A 1 154 ? 44.935 -31.645 8.583 1.00 19.07 ? 182 ARG A CB 1 ATOM 1081 C CG . ARG A 1 154 ? 44.620 -31.046 9.928 1.00 17.59 ? 182 ARG A CG 1 ATOM 1082 C CD . ARG A 1 154 ? 45.803 -30.240 10.501 1.00 13.82 ? 182 ARG A CD 1 ATOM 1083 N NE . ARG A 1 154 ? 46.995 -31.073 10.673 1.00 13.52 ? 182 ARG A NE 1 ATOM 1084 C CZ . ARG A 1 154 ? 47.152 -31.972 11.646 1.00 14.38 ? 182 ARG A CZ 1 ATOM 1085 N NH1 . ARG A 1 154 ? 46.195 -32.177 12.548 1.00 12.75 ? 182 ARG A NH1 1 ATOM 1086 N NH2 . ARG A 1 154 ? 48.259 -32.695 11.708 1.00 13.67 ? 182 ARG A NH2 1 ATOM 1087 N N . GLY A 1 155 ? 44.096 -33.153 5.671 1.00 19.53 ? 183 GLY A N 1 ATOM 1088 C CA . GLY A 1 155 ? 44.741 -33.752 4.524 1.00 19.26 ? 183 GLY A CA 1 ATOM 1089 C C . GLY A 1 155 ? 43.946 -33.735 3.256 1.00 18.50 ? 183 GLY A C 1 ATOM 1090 O O . GLY A 1 155 ? 43.184 -32.827 3.045 1.00 18.75 ? 183 GLY A O 1 ATOM 1091 N N . ILE A 1 156 ? 44.132 -34.770 2.441 1.00 18.48 ? 184 ILE A N 1 ATOM 1092 C CA . ILE A 1 156 ? 43.698 -34.837 1.055 1.00 18.54 ? 184 ILE A CA 1 ATOM 1093 C C . ILE A 1 156 ? 42.872 -36.089 0.831 1.00 18.93 ? 184 ILE A C 1 ATOM 1094 O O . ILE A 1 156 ? 43.248 -37.162 1.283 1.00 19.48 ? 184 ILE A O 1 ATOM 1095 C CB . ILE A 1 156 ? 44.941 -34.956 0.125 1.00 18.74 ? 184 ILE A CB 1 ATOM 1096 C CG1 . ILE A 1 156 ? 45.502 -33.584 -0.212 1.00 18.98 ? 184 ILE A CG1 1 ATOM 1097 C CG2 . ILE A 1 156 ? 44.620 -35.696 -1.174 1.00 18.05 ? 184 ILE A CG2 1 ATOM 1098 C CD1 . ILE A 1 156 ? 46.268 -32.930 0.943 1.00 19.39 ? 184 ILE A CD1 1 ATOM 1099 N N . VAL A 1 157 ? 41.755 -35.966 0.122 1.00 18.95 ? 185 VAL A N 1 ATOM 1100 C CA . VAL A 1 157 ? 41.078 -37.149 -0.394 1.00 18.68 ? 185 VAL A CA 1 ATOM 1101 C C . VAL A 1 157 ? 41.272 -37.182 -1.898 1.00 19.32 ? 185 VAL A C 1 ATOM 1102 O O . VAL A 1 157 ? 40.792 -36.281 -2.595 1.00 20.21 ? 185 VAL A O 1 ATOM 1103 C CB . VAL A 1 157 ? 39.561 -37.173 -0.059 1.00 18.87 ? 185 VAL A CB 1 ATOM 1104 C CG1 . VAL A 1 157 ? 38.876 -35.855 -0.457 1.00 16.92 ? 185 VAL A CG1 1 ATOM 1105 C CG2 . VAL A 1 157 ? 38.871 -38.407 -0.708 1.00 18.10 ? 185 VAL A CG2 1 ATOM 1106 N N . GLU A 1 158 ? 42.000 -38.186 -2.398 1.00 18.96 ? 186 GLU A N 1 ATOM 1107 C CA . GLU A 1 158 ? 42.135 -38.386 -3.834 1.00 18.08 ? 186 GLU A CA 1 ATOM 1108 C C . GLU A 1 158 ? 40.867 -39.097 -4.259 1.00 18.26 ? 186 GLU A C 1 ATOM 1109 O O . GLU A 1 158 ? 40.805 -40.331 -4.265 1.00 18.14 ? 186 GLU A O 1 ATOM 1110 C CB . GLU A 1 158 ? 43.368 -39.229 -4.181 1.00 18.02 ? 186 GLU A CB 1 ATOM 1111 C CG . GLU A 1 158 ? 43.653 -39.228 -5.693 1.00 19.67 ? 186 GLU A CG 1 ATOM 1112 C CD . GLU A 1 158 ? 44.716 -40.218 -6.164 1.00 22.18 ? 186 GLU A CD 1 ATOM 1113 O OE1 . GLU A 1 158 ? 45.663 -40.571 -5.418 1.00 22.12 ? 186 GLU A OE1 1 ATOM 1114 O OE2 . GLU A 1 158 ? 44.595 -40.637 -7.330 1.00 23.34 ? 186 GLU A OE2 1 ATOM 1115 N N . GLY A 1 159 ? 39.843 -38.309 -4.581 1.00 18.52 ? 187 GLY A N 1 ATOM 1116 C CA . GLY A 1 159 ? 38.497 -38.825 -4.903 1.00 18.81 ? 187 GLY A CA 1 ATOM 1117 C C . GLY A 1 159 ? 37.849 -38.206 -6.137 1.00 19.21 ? 187 GLY A C 1 ATOM 1118 O O . GLY A 1 159 ? 36.618 -38.240 -6.288 1.00 19.25 ? 187 GLY A O 1 ATOM 1119 N N . PHE A 1 160 ? 38.669 -37.634 -7.016 1.00 19.15 ? 188 PHE A N 1 ATOM 1120 C CA . PHE A 1 160 ? 38.173 -36.974 -8.214 1.00 19.33 ? 188 PHE A CA 1 ATOM 1121 C C . PHE A 1 160 ? 37.950 -37.988 -9.333 1.00 19.82 ? 188 PHE A C 1 ATOM 1122 O O . PHE A 1 160 ? 38.396 -39.149 -9.241 1.00 20.17 ? 188 PHE A O 1 ATOM 1123 C CB . PHE A 1 160 ? 39.165 -35.901 -8.665 1.00 19.26 ? 188 PHE A CB 1 ATOM 1124 C CG . PHE A 1 160 ? 40.547 -36.410 -8.838 1.00 19.13 ? 188 PHE A CG 1 ATOM 1125 C CD1 . PHE A 1 160 ? 40.904 -37.093 -10.001 1.00 18.57 ? 188 PHE A CD1 1 ATOM 1126 C CD2 . PHE A 1 160 ? 41.497 -36.239 -7.826 1.00 19.10 ? 188 PHE A CD2 1 ATOM 1127 C CE1 . PHE A 1 160 ? 42.197 -37.592 -10.166 1.00 18.67 ? 188 PHE A CE1 1 ATOM 1128 C CE2 . PHE A 1 160 ? 42.790 -36.725 -7.972 1.00 19.78 ? 188 PHE A CE2 1 ATOM 1129 C CZ . PHE A 1 160 ? 43.146 -37.413 -9.161 1.00 19.21 ? 188 PHE A CZ 1 ATOM 1130 N N . TYR A 1 161 ? 37.264 -37.550 -10.388 1.00 20.04 ? 189 TYR A N 1 ATOM 1131 C CA . TYR A 1 161 ? 37.070 -38.347 -11.601 1.00 20.09 ? 189 TYR A CA 1 ATOM 1132 C C . TYR A 1 161 ? 38.144 -38.026 -12.607 1.00 20.87 ? 189 TYR A C 1 ATOM 1133 O O . TYR A 1 161 ? 38.645 -36.906 -12.632 1.00 22.11 ? 189 TYR A O 1 ATOM 1134 C CB . TYR A 1 161 ? 35.742 -38.017 -12.239 1.00 19.42 ? 189 TYR A CB 1 ATOM 1135 C CG . TYR A 1 161 ? 34.538 -38.595 -11.542 1.00 19.18 ? 189 TYR A CG 1 ATOM 1136 C CD1 . TYR A 1 161 ? 33.904 -37.899 -10.501 1.00 17.04 ? 189 TYR A CD1 1 ATOM 1137 C CD2 . TYR A 1 161 ? 34.008 -39.818 -11.939 1.00 17.84 ? 189 TYR A CD2 1 ATOM 1138 C CE1 . TYR A 1 161 ? 32.780 -38.413 -9.871 1.00 17.80 ? 189 TYR A CE1 1 ATOM 1139 C CE2 . TYR A 1 161 ? 32.876 -40.350 -11.304 1.00 19.52 ? 189 TYR A CE2 1 ATOM 1140 C CZ . TYR A 1 161 ? 32.267 -39.635 -10.275 1.00 18.98 ? 189 TYR A CZ 1 ATOM 1141 O OH . TYR A 1 161 ? 31.152 -40.153 -9.659 1.00 20.08 ? 189 TYR A OH 1 ATOM 1142 N N . GLY A 1 162 ? 38.481 -38.986 -13.462 1.00 21.16 ? 190 GLY A N 1 ATOM 1143 C CA . GLY A 1 162 ? 39.542 -38.790 -14.445 1.00 21.70 ? 190 GLY A CA 1 ATOM 1144 C C . GLY A 1 162 ? 40.829 -39.496 -14.041 1.00 22.53 ? 190 GLY A C 1 ATOM 1145 O O . GLY A 1 162 ? 40.851 -40.285 -13.069 1.00 22.52 ? 190 GLY A O 1 ATOM 1146 N N . THR A 1 163 ? 41.906 -39.206 -14.773 1.00 22.48 ? 191 THR A N 1 ATOM 1147 C CA . THR A 1 163 ? 43.178 -39.913 -14.591 1.00 23.10 ? 191 THR A CA 1 ATOM 1148 C C . THR A 1 163 ? 43.760 -39.836 -13.159 1.00 22.64 ? 191 THR A C 1 ATOM 1149 O O . THR A 1 163 ? 44.249 -38.786 -12.726 1.00 22.54 ? 191 THR A O 1 ATOM 1150 C CB . THR A 1 163 ? 44.226 -39.471 -15.634 1.00 23.82 ? 191 THR A CB 1 ATOM 1151 O OG1 . THR A 1 163 ? 43.670 -39.613 -16.952 1.00 26.11 ? 191 THR A OG1 1 ATOM 1152 C CG2 . THR A 1 163 ? 45.484 -40.333 -15.536 1.00 23.76 ? 191 THR A CG2 1 ATOM 1153 N N . PRO A 1 164 ? 43.712 -40.965 -12.432 1.00 22.19 ? 192 PRO A N 1 ATOM 1154 C CA . PRO A 1 164 ? 44.251 -41.066 -11.093 1.00 21.94 ? 192 PRO A CA 1 ATOM 1155 C C . PRO A 1 164 ? 45.709 -40.621 -11.057 1.00 21.81 ? 192 PRO A C 1 ATOM 1156 O O . PRO A 1 164 ? 46.441 -40.806 -12.044 1.00 21.80 ? 192 PRO A O 1 ATOM 1157 C CB . PRO A 1 164 ? 44.189 -42.579 -10.818 1.00 21.88 ? 192 PRO A CB 1 ATOM 1158 C CG . PRO A 1 164 ? 43.146 -43.070 -11.692 1.00 21.63 ? 192 PRO A CG 1 ATOM 1159 C CD . PRO A 1 164 ? 43.293 -42.281 -12.935 1.00 21.85 ? 192 PRO A CD 1 ATOM 1160 N N . TRP A 1 165 ? 46.127 -40.060 -9.922 1.00 21.45 ? 193 TRP A N 1 ATOM 1161 C CA . TRP A 1 165 ? 47.539 -39.779 -9.667 1.00 21.06 ? 193 TRP A CA 1 ATOM 1162 C C . TRP A 1 165 ? 48.390 -41.033 -9.908 1.00 21.25 ? 193 TRP A C 1 ATOM 1163 O O . TRP A 1 165 ? 47.926 -42.161 -9.711 1.00 20.75 ? 193 TRP A O 1 ATOM 1164 C CB . TRP A 1 165 ? 47.751 -39.261 -8.233 1.00 20.66 ? 193 TRP A CB 1 ATOM 1165 C CG . TRP A 1 165 ? 47.320 -37.839 -8.026 1.00 17.96 ? 193 TRP A CG 1 ATOM 1166 C CD1 . TRP A 1 165 ? 46.935 -36.964 -8.985 1.00 16.20 ? 193 TRP A CD1 1 ATOM 1167 C CD2 . TRP A 1 165 ? 47.246 -37.129 -6.780 1.00 14.63 ? 193 TRP A CD2 1 ATOM 1168 N NE1 . TRP A 1 165 ? 46.617 -35.758 -8.420 1.00 15.23 ? 193 TRP A NE1 1 ATOM 1169 C CE2 . TRP A 1 165 ? 46.805 -35.835 -7.066 1.00 14.86 ? 193 TRP A CE2 1 ATOM 1170 C CE3 . TRP A 1 165 ? 47.511 -37.468 -5.455 1.00 15.65 ? 193 TRP A CE3 1 ATOM 1171 C CZ2 . TRP A 1 165 ? 46.625 -34.865 -6.074 1.00 16.10 ? 193 TRP A CZ2 1 ATOM 1172 C CZ3 . TRP A 1 165 ? 47.319 -36.514 -4.466 1.00 15.61 ? 193 TRP A CZ3 1 ATOM 1173 C CH2 . TRP A 1 165 ? 46.875 -35.229 -4.782 1.00 16.69 ? 193 TRP A CH2 1 ATOM 1174 N N . THR A 1 166 ? 49.623 -40.827 -10.346 1.00 21.54 ? 194 THR A N 1 ATOM 1175 C CA . THR A 1 166 ? 50.535 -41.938 -10.567 1.00 22.46 ? 194 THR A CA 1 ATOM 1176 C C . THR A 1 166 ? 51.199 -42.315 -9.249 1.00 23.43 ? 194 THR A C 1 ATOM 1177 O O . THR A 1 166 ? 51.154 -41.543 -8.282 1.00 23.81 ? 194 THR A O 1 ATOM 1178 C CB . THR A 1 166 ? 51.669 -41.568 -11.553 1.00 22.61 ? 194 THR A CB 1 ATOM 1179 O OG1 . THR A 1 166 ? 52.517 -40.562 -10.959 1.00 22.33 ? 194 THR A OG1 1 ATOM 1180 C CG2 . THR A 1 166 ? 51.117 -41.097 -12.908 1.00 20.83 ? 194 THR A CG2 1 ATOM 1181 N N . HIS A 1 167 ? 51.858 -43.472 -9.222 1.00 24.26 ? 195 HIS A N 1 ATOM 1182 C CA . HIS A 1 167 ? 52.705 -43.846 -8.083 1.00 25.05 ? 195 HIS A CA 1 ATOM 1183 C C . HIS A 1 167 ? 53.722 -42.757 -7.650 1.00 25.30 ? 195 HIS A C 1 ATOM 1184 O O . HIS A 1 167 ? 53.785 -42.416 -6.464 1.00 25.06 ? 195 HIS A O 1 ATOM 1185 C CB . HIS A 1 167 ? 53.383 -45.189 -8.345 1.00 25.15 ? 195 HIS A CB 1 ATOM 1186 C CG . HIS A 1 167 ? 54.002 -45.806 -7.128 1.00 26.76 ? 195 HIS A CG 1 ATOM 1187 N ND1 . HIS A 1 167 ? 53.265 -46.195 -6.027 1.00 28.46 ? 195 HIS A ND1 1 ATOM 1188 C CD2 . HIS A 1 167 ? 55.289 -46.127 -6.849 1.00 28.12 ? 195 HIS A CD2 1 ATOM 1189 C CE1 . HIS A 1 167 ? 54.073 -46.719 -5.121 1.00 28.04 ? 195 HIS A CE1 1 ATOM 1190 N NE2 . HIS A 1 167 ? 55.306 -46.694 -5.597 1.00 28.74 ? 195 HIS A NE2 1 ATOM 1191 N N . GLN A 1 168 ? 54.482 -42.185 -8.592 1.00 25.86 ? 196 GLN A N 1 ATOM 1192 C CA . GLN A 1 168 ? 55.433 -41.109 -8.246 1.00 26.66 ? 196 GLN A CA 1 ATOM 1193 C C . GLN A 1 168 ? 54.733 -39.836 -7.777 1.00 25.79 ? 196 GLN A C 1 ATOM 1194 O O . GLN A 1 168 ? 55.263 -39.119 -6.921 1.00 26.17 ? 196 GLN A O 1 ATOM 1195 C CB . GLN A 1 168 ? 56.443 -40.794 -9.371 1.00 27.14 ? 196 GLN A CB 1 ATOM 1196 C CG . GLN A 1 168 ? 57.479 -41.932 -9.674 1.00 32.91 ? 196 GLN A CG 1 ATOM 1197 C CD . GLN A 1 168 ? 58.288 -42.452 -8.423 1.00 38.00 ? 196 GLN A CD 1 ATOM 1198 O OE1 . GLN A 1 168 ? 58.703 -41.666 -7.539 1.00 39.04 ? 196 GLN A OE1 1 ATOM 1199 N NE2 . GLN A 1 168 ? 58.493 -43.785 -8.360 1.00 37.02 ? 196 GLN A NE2 1 ATOM 1200 N N . ASP A 1 169 ? 53.545 -39.558 -8.313 1.00 25.04 ? 197 ASP A N 1 ATOM 1201 C CA . ASP A 1 169 ? 52.756 -38.400 -7.868 1.00 23.83 ? 197 ASP A CA 1 ATOM 1202 C C . ASP A 1 169 ? 52.446 -38.525 -6.367 1.00 23.17 ? 197 ASP A C 1 ATOM 1203 O O . ASP A 1 169 ? 52.685 -37.603 -5.578 1.00 23.15 ? 197 ASP A O 1 ATOM 1204 C CB . ASP A 1 169 ? 51.468 -38.290 -8.683 1.00 23.86 ? 197 ASP A CB 1 ATOM 1205 C CG . ASP A 1 169 ? 51.701 -37.778 -10.115 1.00 25.52 ? 197 ASP A CG 1 ATOM 1206 O OD1 . ASP A 1 169 ? 52.745 -37.114 -10.375 1.00 24.70 ? 197 ASP A OD1 1 ATOM 1207 O OD2 . ASP A 1 169 ? 50.808 -38.034 -10.977 1.00 25.89 ? 197 ASP A OD2 1 ATOM 1208 N N . ARG A 1 170 ? 51.963 -39.701 -5.979 1.00 22.30 ? 198 ARG A N 1 ATOM 1209 C CA . ARG A 1 170 ? 51.530 -39.965 -4.613 1.00 21.14 ? 198 ARG A CA 1 ATOM 1210 C C . ARG A 1 170 ? 52.674 -39.996 -3.614 1.00 20.73 ? 198 ARG A C 1 ATOM 1211 O O . ARG A 1 170 ? 52.531 -39.462 -2.514 1.00 20.60 ? 198 ARG A O 1 ATOM 1212 C CB . ARG A 1 170 ? 50.715 -41.261 -4.550 1.00 21.12 ? 198 ARG A CB 1 ATOM 1213 C CG . ARG A 1 170 ? 49.344 -41.178 -5.196 1.00 19.63 ? 198 ARG A CG 1 ATOM 1214 C CD . ARG A 1 170 ? 48.863 -42.564 -5.560 1.00 17.43 ? 198 ARG A CD 1 ATOM 1215 N NE . ARG A 1 170 ? 47.599 -42.520 -6.283 1.00 17.68 ? 198 ARG A NE 1 ATOM 1216 C CZ . ARG A 1 170 ? 47.107 -43.521 -7.015 1.00 18.64 ? 198 ARG A CZ 1 ATOM 1217 N NH1 . ARG A 1 170 ? 47.774 -44.672 -7.133 1.00 15.37 ? 198 ARG A NH1 1 ATOM 1218 N NH2 . ARG A 1 170 ? 45.932 -43.374 -7.628 1.00 18.68 ? 198 ARG A NH2 1 ATOM 1219 N N . LEU A 1 171 ? 53.799 -40.614 -3.982 1.00 20.47 ? 199 LEU A N 1 ATOM 1220 C CA . LEU A 1 171 ? 54.987 -40.604 -3.116 1.00 20.31 ? 199 LEU A CA 1 ATOM 1221 C C . LEU A 1 171 ? 55.468 -39.161 -2.863 1.00 20.70 ? 199 LEU A C 1 ATOM 1222 O O . LEU A 1 171 ? 55.771 -38.803 -1.708 1.00 21.20 ? 199 LEU A O 1 ATOM 1223 C CB . LEU A 1 171 ? 56.130 -41.469 -3.680 1.00 20.01 ? 199 LEU A CB 1 ATOM 1224 C CG . LEU A 1 171 ? 55.958 -42.992 -3.657 1.00 19.44 ? 199 LEU A CG 1 ATOM 1225 C CD1 . LEU A 1 171 ? 56.912 -43.645 -4.613 1.00 16.60 ? 199 LEU A CD1 1 ATOM 1226 C CD2 . LEU A 1 171 ? 56.147 -43.575 -2.279 1.00 19.78 ? 199 LEU A CD2 1 ATOM 1227 N N . ASP A 1 172 ? 55.521 -38.344 -3.923 1.00 20.10 ? 200 ASP A N 1 ATOM 1228 C CA . ASP A 1 172 ? 55.895 -36.928 -3.801 1.00 20.29 ? 200 ASP A CA 1 ATOM 1229 C C . ASP A 1 172 ? 54.870 -36.170 -2.940 1.00 19.95 ? 200 ASP A C 1 ATOM 1230 O O . ASP A 1 172 ? 55.252 -35.390 -2.060 1.00 20.03 ? 200 ASP A O 1 ATOM 1231 C CB . ASP A 1 172 ? 56.067 -36.282 -5.188 1.00 20.25 ? 200 ASP A CB 1 ATOM 1232 C CG . ASP A 1 172 ? 56.432 -34.799 -5.120 1.00 22.72 ? 200 ASP A CG 1 ATOM 1233 O OD1 . ASP A 1 172 ? 57.606 -34.461 -4.855 1.00 25.65 ? 200 ASP A OD1 1 ATOM 1234 O OD2 . ASP A 1 172 ? 55.548 -33.949 -5.366 1.00 23.19 ? 200 ASP A OD2 1 ATOM 1235 N N . GLN A 1 173 ? 53.580 -36.427 -3.159 1.00 19.21 ? 201 GLN A N 1 ATOM 1236 C CA . GLN A 1 173 ? 52.539 -35.778 -2.361 1.00 18.93 ? 201 GLN A CA 1 ATOM 1237 C C . GLN A 1 173 ? 52.689 -36.091 -0.881 1.00 19.12 ? 201 GLN A C 1 ATOM 1238 O O . GLN A 1 173 ? 52.560 -35.205 -0.047 1.00 19.15 ? 201 GLN A O 1 ATOM 1239 C CB . GLN A 1 173 ? 51.160 -36.208 -2.811 1.00 18.87 ? 201 GLN A CB 1 ATOM 1240 C CG . GLN A 1 173 ? 50.729 -35.641 -4.139 1.00 19.81 ? 201 GLN A CG 1 ATOM 1241 C CD . GLN A 1 173 ? 50.382 -34.190 -4.055 1.00 20.42 ? 201 GLN A CD 1 ATOM 1242 O OE1 . GLN A 1 173 ? 49.578 -33.769 -3.213 1.00 20.99 ? 201 GLN A OE1 1 ATOM 1243 N NE2 . GLN A 1 173 ? 50.979 -33.403 -4.932 1.00 21.99 ? 201 GLN A NE2 1 ATOM 1244 N N . ILE A 1 174 ? 52.968 -37.353 -0.562 1.00 19.29 ? 202 ILE A N 1 ATOM 1245 C CA . ILE A 1 174 ? 53.076 -37.803 0.828 1.00 19.33 ? 202 ILE A CA 1 ATOM 1246 C C . ILE A 1 174 ? 54.217 -37.146 1.594 1.00 19.88 ? 202 ILE A C 1 ATOM 1247 O O . ILE A 1 174 ? 54.061 -36.818 2.752 1.00 19.96 ? 202 ILE A O 1 ATOM 1248 C CB . ILE A 1 174 ? 53.157 -39.345 0.911 1.00 19.29 ? 202 ILE A CB 1 ATOM 1249 C CG1 . ILE A 1 174 ? 51.757 -39.910 0.733 1.00 18.77 ? 202 ILE A CG1 1 ATOM 1250 C CG2 . ILE A 1 174 ? 53.749 -39.819 2.238 1.00 16.85 ? 202 ILE A CG2 1 ATOM 1251 C CD1 . ILE A 1 174 ? 51.742 -41.353 0.472 1.00 20.21 ? 202 ILE A CD1 1 ATOM 1252 N N . LYS A 1 175 ? 55.352 -36.956 0.934 1.00 20.63 ? 203 LYS A N 1 ATOM 1253 C CA . LYS A 1 175 ? 56.489 -36.237 1.489 1.00 21.44 ? 203 LYS A CA 1 ATOM 1254 C C . LYS A 1 175 ? 56.053 -34.790 1.698 1.00 20.36 ? 203 LYS A C 1 ATOM 1255 O O . LYS A 1 175 ? 56.387 -34.177 2.713 1.00 21.22 ? 203 LYS A O 1 ATOM 1256 C CB . LYS A 1 175 ? 57.696 -36.337 0.518 1.00 22.42 ? 203 LYS A CB 1 ATOM 1257 C CG . LYS A 1 175 ? 59.025 -35.767 1.031 1.00 27.49 ? 203 LYS A CG 1 ATOM 1258 C CD . LYS A 1 175 ? 59.815 -36.763 1.974 1.00 33.71 ? 203 LYS A CD 1 ATOM 1259 C CE . LYS A 1 175 ? 60.781 -36.035 2.984 1.00 34.65 ? 203 LYS A CE 1 ATOM 1260 N NZ . LYS A 1 175 ? 61.823 -35.139 2.349 1.00 34.93 ? 203 LYS A NZ 1 ATOM 1261 N N . PHE A 1 176 ? 55.261 -34.264 0.761 1.00 18.99 ? 204 PHE A N 1 ATOM 1262 C CA . PHE A 1 176 ? 54.782 -32.886 0.852 1.00 17.43 ? 204 PHE A CA 1 ATOM 1263 C C . PHE A 1 176 ? 53.804 -32.671 2.043 1.00 17.43 ? 204 PHE A C 1 ATOM 1264 O O . PHE A 1 176 ? 53.886 -31.656 2.746 1.00 17.34 ? 204 PHE A O 1 ATOM 1265 C CB . PHE A 1 176 ? 54.196 -32.460 -0.501 1.00 16.91 ? 204 PHE A CB 1 ATOM 1266 C CG . PHE A 1 176 ? 53.553 -31.097 -0.497 1.00 15.41 ? 204 PHE A CG 1 ATOM 1267 C CD1 . PHE A 1 176 ? 54.335 -29.934 -0.453 1.00 13.59 ? 204 PHE A CD1 1 ATOM 1268 C CD2 . PHE A 1 176 ? 52.158 -30.977 -0.536 1.00 12.33 ? 204 PHE A CD2 1 ATOM 1269 C CE1 . PHE A 1 176 ? 53.736 -28.662 -0.437 1.00 14.65 ? 204 PHE A CE1 1 ATOM 1270 C CE2 . PHE A 1 176 ? 51.536 -29.717 -0.533 1.00 12.12 ? 204 PHE A CE2 1 ATOM 1271 C CZ . PHE A 1 176 ? 52.309 -28.554 -0.483 1.00 12.95 ? 204 PHE A CZ 1 ATOM 1272 N N . TYR A 1 177 ? 52.916 -33.636 2.288 1.00 16.64 ? 205 TYR A N 1 ATOM 1273 C CA . TYR A 1 177 ? 51.978 -33.550 3.399 1.00 16.42 ? 205 TYR A CA 1 ATOM 1274 C C . TYR A 1 177 ? 52.721 -33.478 4.716 1.00 17.32 ? 205 TYR A C 1 ATOM 1275 O O . TYR A 1 177 ? 52.499 -32.554 5.506 1.00 17.89 ? 205 TYR A O 1 ATOM 1276 C CB . TYR A 1 177 ? 50.943 -34.702 3.385 1.00 16.16 ? 205 TYR A CB 1 ATOM 1277 C CG . TYR A 1 177 ? 50.177 -34.817 2.077 1.00 13.24 ? 205 TYR A CG 1 ATOM 1278 C CD1 . TYR A 1 177 ? 50.021 -33.721 1.234 1.00 11.08 ? 205 TYR A CD1 1 ATOM 1279 C CD2 . TYR A 1 177 ? 49.635 -36.022 1.675 1.00 13.68 ? 205 TYR A CD2 1 ATOM 1280 C CE1 . TYR A 1 177 ? 49.368 -33.831 0.016 1.00 11.25 ? 205 TYR A CE1 1 ATOM 1281 C CE2 . TYR A 1 177 ? 48.940 -36.144 0.449 1.00 12.86 ? 205 TYR A CE2 1 ATOM 1282 C CZ . TYR A 1 177 ? 48.816 -35.041 -0.362 1.00 12.63 ? 205 TYR A CZ 1 ATOM 1283 O OH . TYR A 1 177 ? 48.146 -35.154 -1.554 1.00 14.33 ? 205 TYR A OH 1 ATOM 1284 N N . GLY A 1 178 ? 53.647 -34.418 4.922 1.00 17.94 ? 206 GLY A N 1 ATOM 1285 C CA . GLY A 1 178 ? 54.424 -34.504 6.150 1.00 17.80 ? 206 GLY A CA 1 ATOM 1286 C C . GLY A 1 178 ? 55.121 -33.189 6.433 1.00 18.72 ? 206 GLY A C 1 ATOM 1287 O O . GLY A 1 178 ? 55.133 -32.710 7.574 1.00 18.66 ? 206 GLY A O 1 ATOM 1288 N N . GLU A 1 179 ? 55.683 -32.583 5.387 1.00 18.85 ? 207 GLU A N 1 ATOM 1289 C CA . GLU A 1 179 ? 56.429 -31.351 5.559 1.00 19.04 ? 207 GLU A CA 1 ATOM 1290 C C . GLU A 1 179 ? 55.532 -30.177 5.951 1.00 18.37 ? 207 GLU A C 1 ATOM 1291 O O . GLU A 1 179 ? 56.023 -29.163 6.472 1.00 17.82 ? 207 GLU A O 1 ATOM 1292 C CB . GLU A 1 179 ? 57.219 -31.016 4.307 1.00 19.53 ? 207 GLU A CB 1 ATOM 1293 C CG . GLU A 1 179 ? 58.509 -31.784 4.143 1.00 23.34 ? 207 GLU A CG 1 ATOM 1294 C CD . GLU A 1 179 ? 59.225 -31.443 2.818 1.00 30.14 ? 207 GLU A CD 1 ATOM 1295 O OE1 . GLU A 1 179 ? 58.520 -31.022 1.852 1.00 29.23 ? 207 GLU A OE1 1 ATOM 1296 O OE2 . GLU A 1 179 ? 60.487 -31.600 2.757 1.00 33.77 ? 207 GLU A OE2 1 ATOM 1297 N N . ASN A 1 180 ? 54.226 -30.315 5.710 1.00 17.76 ? 208 ASN A N 1 ATOM 1298 C CA . ASN A 1 180 ? 53.267 -29.231 5.982 1.00 17.01 ? 208 ASN A CA 1 ATOM 1299 C C . ASN A 1 180 ? 52.234 -29.660 7.042 1.00 16.86 ? 208 ASN A C 1 ATOM 1300 O O . ASN A 1 180 ? 51.174 -29.039 7.206 1.00 16.52 ? 208 ASN A O 1 ATOM 1301 C CB . ASN A 1 180 ? 52.604 -28.764 4.678 1.00 16.45 ? 208 ASN A CB 1 ATOM 1302 C CG . ASN A 1 180 ? 53.575 -28.032 3.752 1.00 16.66 ? 208 ASN A CG 1 ATOM 1303 O OD1 . ASN A 1 180 ? 53.789 -26.824 3.886 1.00 18.11 ? 208 ASN A OD1 1 ATOM 1304 N ND2 . ASN A 1 180 ? 54.164 -28.760 2.802 1.00 14.24 ? 208 ASN A ND2 1 ATOM 1305 N N . LYS A 1 181 ? 52.574 -30.736 7.756 1.00 16.55 ? 209 LYS A N 1 ATOM 1306 C CA . LYS A 1 181 ? 51.835 -31.243 8.916 1.00 16.18 ? 209 LYS A CA 1 ATOM 1307 C C . LYS A 1 181 ? 50.410 -31.689 8.594 1.00 16.24 ? 209 LYS A C 1 ATOM 1308 O O . LYS A 1 181 ? 49.503 -31.628 9.455 1.00 16.44 ? 209 LYS A O 1 ATOM 1309 C CB . LYS A 1 181 ? 51.830 -30.209 10.059 1.00 16.28 ? 209 LYS A CB 1 ATOM 1310 C CG . LYS A 1 181 ? 53.190 -29.705 10.486 1.00 15.15 ? 209 LYS A CG 1 ATOM 1311 C CD . LYS A 1 181 ? 53.043 -28.622 11.528 1.00 13.84 ? 209 LYS A CD 1 ATOM 1312 C CE . LYS A 1 181 ? 54.375 -28.289 12.167 1.00 12.87 ? 209 LYS A CE 1 ATOM 1313 N NZ . LYS A 1 181 ? 55.106 -27.191 11.466 1.00 13.17 ? 209 LYS A NZ 1 ATOM 1314 N N . LEU A 1 182 ? 50.200 -32.103 7.350 1.00 15.92 ? 210 LEU A N 1 ATOM 1315 C CA . LEU A 1 182 ? 48.941 -32.734 6.953 1.00 15.86 ? 210 LEU A CA 1 ATOM 1316 C C . LEU A 1 182 ? 49.086 -34.207 7.288 1.00 15.69 ? 210 LEU A C 1 ATOM 1317 O O . LEU A 1 182 ? 50.090 -34.823 6.937 1.00 15.31 ? 210 LEU A O 1 ATOM 1318 C CB . LEU A 1 182 ? 48.674 -32.528 5.460 1.00 15.32 ? 210 LEU A CB 1 ATOM 1319 C CG . LEU A 1 182 ? 48.406 -31.076 5.037 1.00 15.99 ? 210 LEU A CG 1 ATOM 1320 C CD1 . LEU A 1 182 ? 48.646 -30.890 3.551 1.00 15.55 ? 210 LEU A CD1 1 ATOM 1321 C CD2 . LEU A 1 182 ? 47.012 -30.593 5.405 1.00 16.49 ? 210 LEU A CD2 1 ATOM 1322 N N . ASN A 1 183 ? 48.101 -34.776 7.975 1.00 16.07 ? 211 ASN A N 1 ATOM 1323 C CA . ASN A 1 183 ? 48.271 -36.133 8.543 1.00 16.55 ? 211 ASN A CA 1 ATOM 1324 C C . ASN A 1 183 ? 47.358 -37.184 7.960 1.00 16.59 ? 211 ASN A C 1 ATOM 1325 O O . ASN A 1 183 ? 47.277 -38.283 8.494 1.00 17.27 ? 211 ASN A O 1 ATOM 1326 C CB . ASN A 1 183 ? 48.118 -36.127 10.071 1.00 15.88 ? 211 ASN A CB 1 ATOM 1327 C CG . ASN A 1 183 ? 46.700 -35.762 10.525 1.00 16.85 ? 211 ASN A CG 1 ATOM 1328 O OD1 . ASN A 1 183 ? 45.774 -35.641 9.708 1.00 14.34 ? 211 ASN A OD1 1 ATOM 1329 N ND2 . ASN A 1 183 ? 46.532 -35.567 11.843 1.00 16.09 ? 211 ASN A ND2 1 ATOM 1330 N N . THR A 1 184 ? 46.671 -36.847 6.873 1.00 16.58 ? 212 THR A N 1 ATOM 1331 C CA . THR A 1 184 ? 45.653 -37.720 6.300 1.00 16.10 ? 212 THR A CA 1 ATOM 1332 C C . THR A 1 184 ? 45.702 -37.735 4.775 1.00 16.20 ? 212 THR A C 1 ATOM 1333 O O . THR A 1 184 ? 45.819 -36.688 4.143 1.00 15.95 ? 212 THR A O 1 ATOM 1334 C CB . THR A 1 184 ? 44.262 -37.266 6.768 1.00 15.69 ? 212 THR A CB 1 ATOM 1335 O OG1 . THR A 1 184 ? 44.222 -37.331 8.190 1.00 17.18 ? 212 THR A OG1 1 ATOM 1336 C CG2 . THR A 1 184 ? 43.150 -38.143 6.203 1.00 14.57 ? 212 THR A CG2 1 ATOM 1337 N N . TYR A 1 185 ? 45.603 -38.928 4.191 1.00 16.15 ? 213 TYR A N 1 ATOM 1338 C CA . TYR A 1 185 ? 45.525 -39.079 2.735 1.00 16.21 ? 213 TYR A CA 1 ATOM 1339 C C . TYR A 1 185 ? 44.575 -40.211 2.452 1.00 16.27 ? 213 TYR A C 1 ATOM 1340 O O . TYR A 1 185 ? 44.805 -41.351 2.895 1.00 16.93 ? 213 TYR A O 1 ATOM 1341 C CB . TYR A 1 185 ? 46.891 -39.365 2.109 1.00 15.97 ? 213 TYR A CB 1 ATOM 1342 C CG . TYR A 1 185 ? 46.764 -39.910 0.730 1.00 16.86 ? 213 TYR A CG 1 ATOM 1343 C CD1 . TYR A 1 185 ? 46.408 -39.086 -0.337 1.00 16.94 ? 213 TYR A CD1 1 ATOM 1344 C CD2 . TYR A 1 185 ? 46.977 -41.256 0.485 1.00 18.21 ? 213 TYR A CD2 1 ATOM 1345 C CE1 . TYR A 1 185 ? 46.257 -39.598 -1.613 1.00 18.94 ? 213 TYR A CE1 1 ATOM 1346 C CE2 . TYR A 1 185 ? 46.830 -41.785 -0.794 1.00 19.83 ? 213 TYR A CE2 1 ATOM 1347 C CZ . TYR A 1 185 ? 46.470 -40.953 -1.838 1.00 20.23 ? 213 TYR A CZ 1 ATOM 1348 O OH . TYR A 1 185 ? 46.338 -41.482 -3.104 1.00 20.99 ? 213 TYR A OH 1 ATOM 1349 N N . ILE A 1 186 ? 43.481 -39.899 1.764 1.00 15.77 ? 214 ILE A N 1 ATOM 1350 C CA . ILE A 1 186 ? 42.462 -40.895 1.522 1.00 15.62 ? 214 ILE A CA 1 ATOM 1351 C C . ILE A 1 186 ? 42.577 -41.360 0.097 1.00 16.38 ? 214 ILE A C 1 ATOM 1352 O O . ILE A 1 186 ? 42.468 -40.556 -0.831 1.00 16.49 ? 214 ILE A O 1 ATOM 1353 C CB . ILE A 1 186 ? 41.038 -40.357 1.788 1.00 15.72 ? 214 ILE A CB 1 ATOM 1354 C CG1 . ILE A 1 186 ? 40.944 -39.834 3.222 1.00 13.93 ? 214 ILE A CG1 1 ATOM 1355 C CG2 . ILE A 1 186 ? 39.987 -41.459 1.505 1.00 13.78 ? 214 ILE A CG2 1 ATOM 1356 C CD1 . ILE A 1 186 ? 39.663 -39.187 3.533 1.00 14.55 ? 214 ILE A CD1 1 ATOM 1357 N N . TYR A 1 187 ? 42.805 -42.653 -0.068 1.00 16.58 ? 215 TYR A N 1 ATOM 1358 C CA . TYR A 1 187 ? 42.887 -43.233 -1.379 1.00 17.80 ? 215 TYR A CA 1 ATOM 1359 C C . TYR A 1 187 ? 41.494 -43.622 -1.845 1.00 18.27 ? 215 TYR A C 1 ATOM 1360 O O . TYR A 1 187 ? 40.919 -44.569 -1.320 1.00 18.52 ? 215 TYR A O 1 ATOM 1361 C CB . TYR A 1 187 ? 43.787 -44.468 -1.351 1.00 18.24 ? 215 TYR A CB 1 ATOM 1362 C CG . TYR A 1 187 ? 43.864 -45.152 -2.686 1.00 19.32 ? 215 TYR A CG 1 ATOM 1363 C CD1 . TYR A 1 187 ? 44.824 -44.776 -3.608 1.00 18.84 ? 215 TYR A CD1 1 ATOM 1364 C CD2 . TYR A 1 187 ? 42.956 -46.166 -3.041 1.00 20.63 ? 215 TYR A CD2 1 ATOM 1365 C CE1 . TYR A 1 187 ? 44.903 -45.379 -4.845 1.00 20.17 ? 215 TYR A CE1 1 ATOM 1366 C CE2 . TYR A 1 187 ? 43.025 -46.776 -4.299 1.00 21.94 ? 215 TYR A CE2 1 ATOM 1367 C CZ . TYR A 1 187 ? 44.004 -46.368 -5.188 1.00 21.65 ? 215 TYR A CZ 1 ATOM 1368 O OH . TYR A 1 187 ? 44.108 -46.945 -6.429 1.00 25.42 ? 215 TYR A OH 1 ATOM 1369 N N . ALA A 1 188 ? 40.950 -42.897 -2.824 1.00 18.72 ? 216 ALA A N 1 ATOM 1370 C CA . ALA A 1 188 ? 39.602 -43.192 -3.348 1.00 18.99 ? 216 ALA A CA 1 ATOM 1371 C C . ALA A 1 188 ? 39.387 -42.683 -4.798 1.00 19.37 ? 216 ALA A C 1 ATOM 1372 O O . ALA A 1 188 ? 38.412 -41.988 -5.077 1.00 19.76 ? 216 ALA A O 1 ATOM 1373 C CB . ALA A 1 188 ? 38.518 -42.622 -2.389 1.00 17.78 ? 216 ALA A CB 1 ATOM 1374 N N . PRO A 1 189 ? 40.306 -42.996 -5.723 1.00 19.79 ? 217 PRO A N 1 ATOM 1375 C CA . PRO A 1 189 ? 40.079 -42.399 -7.048 1.00 20.35 ? 217 PRO A CA 1 ATOM 1376 C C . PRO A 1 189 ? 38.932 -43.056 -7.792 1.00 20.90 ? 217 PRO A C 1 ATOM 1377 O O . PRO A 1 189 ? 38.895 -44.272 -7.920 1.00 21.83 ? 217 PRO A O 1 ATOM 1378 C CB . PRO A 1 189 ? 41.394 -42.627 -7.787 1.00 20.12 ? 217 PRO A CB 1 ATOM 1379 C CG . PRO A 1 189 ? 42.154 -43.632 -6.972 1.00 20.29 ? 217 PRO A CG 1 ATOM 1380 C CD . PRO A 1 189 ? 41.641 -43.609 -5.586 1.00 19.61 ? 217 PRO A CD 1 ATOM 1381 N N . LYS A 1 190 ? 38.016 -42.243 -8.291 1.00 21.24 ? 218 LYS A N 1 ATOM 1382 C CA . LYS A 1 190 ? 36.775 -42.736 -8.866 1.00 21.46 ? 218 LYS A CA 1 ATOM 1383 C C . LYS A 1 190 ? 37.029 -43.691 -10.000 1.00 22.80 ? 218 LYS A C 1 ATOM 1384 O O . LYS A 1 190 ? 36.269 -44.659 -10.195 1.00 23.07 ? 218 LYS A O 1 ATOM 1385 C CB . LYS A 1 190 ? 35.906 -41.576 -9.360 1.00 20.97 ? 218 LYS A CB 1 ATOM 1386 C CG . LYS A 1 190 ? 35.200 -40.777 -8.269 1.00 19.21 ? 218 LYS A CG 1 ATOM 1387 C CD . LYS A 1 190 ? 33.924 -41.452 -7.797 1.00 17.07 ? 218 LYS A CD 1 ATOM 1388 C CE . LYS A 1 190 ? 33.202 -40.623 -6.785 1.00 15.81 ? 218 LYS A CE 1 ATOM 1389 N NZ . LYS A 1 190 ? 34.054 -40.561 -5.558 1.00 16.25 ? 218 LYS A NZ 1 ATOM 1390 N N . ASP A 1 191 ? 38.100 -43.435 -10.740 1.00 24.03 ? 219 ASP A N 1 ATOM 1391 C CA . ASP A 1 191 ? 38.332 -44.180 -11.955 1.00 26.14 ? 219 ASP A CA 1 ATOM 1392 C C . ASP A 1 191 ? 39.325 -45.304 -11.775 1.00 27.30 ? 219 ASP A C 1 ATOM 1393 O O . ASP A 1 191 ? 39.677 -45.961 -12.760 1.00 28.25 ? 219 ASP A O 1 ATOM 1394 C CB . ASP A 1 191 ? 38.701 -43.270 -13.139 1.00 26.14 ? 219 ASP A CB 1 ATOM 1395 C CG . ASP A 1 191 ? 37.507 -42.424 -13.628 1.00 28.39 ? 219 ASP A CG 1 ATOM 1396 O OD1 . ASP A 1 191 ? 36.361 -42.934 -13.634 1.00 28.24 ? 219 ASP A OD1 1 ATOM 1397 O OD2 . ASP A 1 191 ? 37.708 -41.241 -14.006 1.00 31.19 ? 219 ASP A OD2 1 ATOM 1398 N N . ASP A 1 192 ? 39.778 -45.541 -10.538 1.00 27.94 ? 220 ASP A N 1 ATOM 1399 C CA . ASP A 1 192 ? 40.518 -46.780 -10.258 1.00 28.52 ? 220 ASP A CA 1 ATOM 1400 C C . ASP A 1 192 ? 39.507 -47.927 -10.300 1.00 28.68 ? 220 ASP A C 1 ATOM 1401 O O . ASP A 1 192 ? 38.578 -47.965 -9.494 1.00 28.76 ? 220 ASP A O 1 ATOM 1402 C CB . ASP A 1 192 ? 41.234 -46.756 -8.902 1.00 28.95 ? 220 ASP A CB 1 ATOM 1403 C CG . ASP A 1 192 ? 41.818 -48.131 -8.516 1.00 29.50 ? 220 ASP A CG 1 ATOM 1404 O OD1 . ASP A 1 192 ? 41.955 -48.990 -9.406 1.00 32.50 ? 220 ASP A OD1 1 ATOM 1405 O OD2 . ASP A 1 192 ? 42.149 -48.359 -7.330 1.00 28.91 ? 220 ASP A OD2 1 ATOM 1406 N N . PRO A 1 193 ? 39.662 -48.852 -11.260 1.00 28.72 ? 221 PRO A N 1 ATOM 1407 C CA . PRO A 1 193 ? 38.612 -49.880 -11.384 1.00 28.34 ? 221 PRO A CA 1 ATOM 1408 C C . PRO A 1 193 ? 38.382 -50.690 -10.102 1.00 27.79 ? 221 PRO A C 1 ATOM 1409 O O . PRO A 1 193 ? 37.243 -51.041 -9.810 1.00 28.23 ? 221 PRO A O 1 ATOM 1410 C CB . PRO A 1 193 ? 39.103 -50.772 -12.543 1.00 28.25 ? 221 PRO A CB 1 ATOM 1411 C CG . PRO A 1 193 ? 40.578 -50.458 -12.675 1.00 29.07 ? 221 PRO A CG 1 ATOM 1412 C CD . PRO A 1 193 ? 40.714 -48.999 -12.282 1.00 28.32 ? 221 PRO A CD 1 ATOM 1413 N N . TYR A 1 194 ? 39.436 -50.952 -9.332 1.00 27.31 ? 222 TYR A N 1 ATOM 1414 C CA . TYR A 1 194 ? 39.327 -51.759 -8.106 1.00 26.77 ? 222 TYR A CA 1 ATOM 1415 C C . TYR A 1 194 ? 38.807 -51.004 -6.903 1.00 26.37 ? 222 TYR A C 1 ATOM 1416 O O . TYR A 1 194 ? 38.501 -51.608 -5.873 1.00 26.62 ? 222 TYR A O 1 ATOM 1417 C CB . TYR A 1 194 ? 40.674 -52.373 -7.747 1.00 26.95 ? 222 TYR A CB 1 ATOM 1418 C CG . TYR A 1 194 ? 41.284 -53.113 -8.886 1.00 28.50 ? 222 TYR A CG 1 ATOM 1419 C CD1 . TYR A 1 194 ? 40.762 -54.332 -9.305 1.00 30.32 ? 222 TYR A CD1 1 ATOM 1420 C CD2 . TYR A 1 194 ? 42.368 -52.581 -9.575 1.00 29.73 ? 222 TYR A CD2 1 ATOM 1421 C CE1 . TYR A 1 194 ? 41.312 -55.010 -10.390 1.00 32.57 ? 222 TYR A CE1 1 ATOM 1422 C CE2 . TYR A 1 194 ? 42.931 -53.247 -10.648 1.00 31.54 ? 222 TYR A CE2 1 ATOM 1423 C CZ . TYR A 1 194 ? 42.399 -54.458 -11.055 1.00 33.71 ? 222 TYR A CZ 1 ATOM 1424 O OH . TYR A 1 194 ? 42.971 -55.123 -12.124 1.00 36.92 ? 222 TYR A OH 1 ATOM 1425 N N . HIS A 1 195 ? 38.733 -49.687 -7.011 1.00 25.95 ? 223 HIS A N 1 ATOM 1426 C CA . HIS A 1 195 ? 38.144 -48.895 -5.963 1.00 26.17 ? 223 HIS A CA 1 ATOM 1427 C C . HIS A 1 195 ? 36.617 -48.905 -6.034 1.00 26.68 ? 223 HIS A C 1 ATOM 1428 O O . HIS A 1 195 ? 35.962 -48.795 -4.991 1.00 26.81 ? 223 HIS A O 1 ATOM 1429 C CB . HIS A 1 195 ? 38.638 -47.444 -6.003 1.00 25.96 ? 223 HIS A CB 1 ATOM 1430 C CG . HIS A 1 195 ? 37.891 -46.544 -5.074 1.00 25.88 ? 223 HIS A CG 1 ATOM 1431 N ND1 . HIS A 1 195 ? 37.973 -46.659 -3.703 1.00 26.20 ? 223 HIS A ND1 1 ATOM 1432 C CD2 . HIS A 1 195 ? 37.010 -45.546 -5.316 1.00 27.75 ? 223 HIS A CD2 1 ATOM 1433 C CE1 . HIS A 1 195 ? 37.180 -45.763 -3.140 1.00 27.59 ? 223 HIS A CE1 1 ATOM 1434 N NE2 . HIS A 1 195 ? 36.586 -45.071 -4.096 1.00 28.52 ? 223 HIS A NE2 1 ATOM 1435 N N . ARG A 1 196 ? 36.055 -49.018 -7.244 1.00 26.76 ? 224 ARG A N 1 ATOM 1436 C CA . ARG A 1 196 ? 34.630 -48.724 -7.458 1.00 27.37 ? 224 ARG A CA 1 ATOM 1437 C C . ARG A 1 196 ? 33.945 -49.644 -8.477 1.00 28.20 ? 224 ARG A C 1 ATOM 1438 O O . ARG A 1 196 ? 33.173 -50.532 -8.115 1.00 27.54 ? 224 ARG A O 1 ATOM 1439 C CB . ARG A 1 196 ? 34.481 -47.258 -7.877 1.00 27.29 ? 224 ARG A CB 1 ATOM 1440 C CG . ARG A 1 196 ? 33.086 -46.702 -7.854 1.00 27.27 ? 224 ARG A CG 1 ATOM 1441 C CD . ARG A 1 196 ? 33.134 -45.193 -7.887 1.00 28.26 ? 224 ARG A CD 1 ATOM 1442 N NE . ARG A 1 196 ? 31.840 -44.614 -7.517 1.00 33.12 ? 224 ARG A NE 1 ATOM 1443 C CZ . ARG A 1 196 ? 30.936 -44.133 -8.381 1.00 34.03 ? 224 ARG A CZ 1 ATOM 1444 N NH1 . ARG A 1 196 ? 31.187 -44.144 -9.691 1.00 33.46 ? 224 ARG A NH1 1 ATOM 1445 N NH2 . ARG A 1 196 ? 29.780 -43.635 -7.938 1.00 31.77 ? 224 ARG A NH2 1 ATOM 1446 N N . GLU A 1 197 ? 34.245 -49.414 -9.753 1.00 29.89 ? 225 GLU A N 1 ATOM 1447 C CA . GLU A 1 197 ? 33.654 -50.153 -10.875 1.00 31.38 ? 225 GLU A CA 1 ATOM 1448 C C . GLU A 1 197 ? 33.704 -51.662 -10.606 1.00 30.81 ? 225 GLU A C 1 ATOM 1449 O O . GLU A 1 197 ? 32.756 -52.388 -10.888 1.00 30.66 ? 225 GLU A O 1 ATOM 1450 C CB . GLU A 1 197 ? 34.395 -49.792 -12.189 1.00 32.12 ? 225 GLU A CB 1 ATOM 1451 C CG . GLU A 1 197 ? 33.637 -50.111 -13.504 1.00 37.23 ? 225 GLU A CG 1 ATOM 1452 C CD . GLU A 1 197 ? 34.547 -50.551 -14.691 1.00 43.92 ? 225 GLU A CD 1 ATOM 1453 O OE1 . GLU A 1 197 ? 35.748 -50.158 -14.764 1.00 46.36 ? 225 GLU A OE1 1 ATOM 1454 O OE2 . GLU A 1 197 ? 34.045 -51.294 -15.572 1.00 45.97 ? 225 GLU A OE2 1 ATOM 1455 N N . LYS A 1 198 ? 34.818 -52.112 -10.037 1.00 30.77 ? 226 LYS A N 1 ATOM 1456 C CA . LYS A 1 198 ? 35.075 -53.534 -9.791 1.00 30.71 ? 226 LYS A CA 1 ATOM 1457 C C . LYS A 1 198 ? 35.562 -53.781 -8.346 1.00 29.91 ? 226 LYS A C 1 ATOM 1458 O O . LYS A 1 198 ? 36.493 -54.552 -8.108 1.00 29.67 ? 226 LYS A O 1 ATOM 1459 C CB . LYS A 1 198 ? 36.105 -54.034 -10.806 1.00 31.16 ? 226 LYS A CB 1 ATOM 1460 C CG . LYS A 1 198 ? 35.523 -54.320 -12.171 1.00 33.62 ? 226 LYS A CG 1 ATOM 1461 C CD . LYS A 1 198 ? 36.624 -54.627 -13.193 1.00 39.06 ? 226 LYS A CD 1 ATOM 1462 C CE . LYS A 1 198 ? 35.998 -54.904 -14.587 1.00 42.99 ? 226 LYS A CE 1 ATOM 1463 N NZ . LYS A 1 198 ? 37.038 -55.112 -15.647 1.00 43.58 ? 226 LYS A NZ 1 ATOM 1464 N N . TRP A 1 199 ? 34.911 -53.126 -7.388 1.00 29.01 ? 227 TRP A N 1 ATOM 1465 C CA . TRP A 1 199 ? 35.341 -53.136 -5.993 1.00 28.50 ? 227 TRP A CA 1 ATOM 1466 C C . TRP A 1 199 ? 35.564 -54.513 -5.340 1.00 28.00 ? 227 TRP A C 1 ATOM 1467 O O . TRP A 1 199 ? 36.291 -54.620 -4.346 1.00 27.65 ? 227 TRP A O 1 ATOM 1468 C CB . TRP A 1 199 ? 34.380 -52.299 -5.154 1.00 28.53 ? 227 TRP A CB 1 ATOM 1469 C CG . TRP A 1 199 ? 33.013 -52.866 -5.083 1.00 28.90 ? 227 TRP A CG 1 ATOM 1470 C CD1 . TRP A 1 199 ? 32.001 -52.663 -5.975 1.00 28.59 ? 227 TRP A CD1 1 ATOM 1471 C CD2 . TRP A 1 199 ? 32.493 -53.733 -4.065 1.00 28.51 ? 227 TRP A CD2 1 ATOM 1472 N NE1 . TRP A 1 199 ? 30.880 -53.350 -5.574 1.00 29.84 ? 227 TRP A NE1 1 ATOM 1473 C CE2 . TRP A 1 199 ? 31.155 -54.021 -4.412 1.00 28.91 ? 227 TRP A CE2 1 ATOM 1474 C CE3 . TRP A 1 199 ? 33.033 -54.309 -2.904 1.00 28.11 ? 227 TRP A CE3 1 ATOM 1475 C CZ2 . TRP A 1 199 ? 30.346 -54.856 -3.642 1.00 28.51 ? 227 TRP A CZ2 1 ATOM 1476 C CZ3 . TRP A 1 199 ? 32.234 -55.139 -2.135 1.00 26.87 ? 227 TRP A CZ3 1 ATOM 1477 C CH2 . TRP A 1 199 ? 30.904 -55.407 -2.508 1.00 29.41 ? 227 TRP A CH2 1 ATOM 1478 N N . ARG A 1 200 ? 34.953 -55.560 -5.891 1.00 27.70 ? 228 ARG A N 1 ATOM 1479 C CA . ARG A 1 200 ? 35.081 -56.911 -5.312 1.00 27.41 ? 228 ARG A CA 1 ATOM 1480 C C . ARG A 1 200 ? 36.402 -57.578 -5.650 1.00 27.75 ? 228 ARG A C 1 ATOM 1481 O O . ARG A 1 200 ? 36.877 -58.424 -4.899 1.00 27.53 ? 228 ARG A O 1 ATOM 1482 C CB . ARG A 1 200 ? 33.960 -57.824 -5.778 1.00 27.13 ? 228 ARG A CB 1 ATOM 1483 C CG . ARG A 1 200 ? 32.574 -57.451 -5.290 1.00 25.69 ? 228 ARG A CG 1 ATOM 1484 C CD . ARG A 1 200 ? 31.588 -58.412 -5.899 1.00 23.34 ? 228 ARG A CD 1 ATOM 1485 N NE . ARG A 1 200 ? 30.214 -58.059 -5.603 1.00 23.43 ? 228 ARG A NE 1 ATOM 1486 C CZ . ARG A 1 200 ? 29.536 -57.114 -6.248 1.00 24.95 ? 228 ARG A CZ 1 ATOM 1487 N NH1 . ARG A 1 200 ? 30.139 -56.416 -7.211 1.00 24.57 ? 228 ARG A NH1 1 ATOM 1488 N NH2 . ARG A 1 200 ? 28.270 -56.845 -5.909 1.00 21.75 ? 228 ARG A NH2 1 ATOM 1489 N N . GLU A 1 201 ? 36.985 -57.187 -6.781 1.00 28.27 ? 229 GLU A N 1 ATOM 1490 C CA . GLU A 1 201 ? 38.173 -57.846 -7.312 1.00 29.36 ? 229 GLU A CA 1 ATOM 1491 C C . GLU A 1 201 ? 39.445 -57.464 -6.557 1.00 28.86 ? 229 GLU A C 1 ATOM 1492 O O . GLU A 1 201 ? 39.608 -56.314 -6.176 1.00 28.81 ? 229 GLU A O 1 ATOM 1493 C CB . GLU A 1 201 ? 38.305 -57.587 -8.819 1.00 29.97 ? 229 GLU A CB 1 ATOM 1494 C CG . GLU A 1 201 ? 37.407 -58.506 -9.675 1.00 34.25 ? 229 GLU A CG 1 ATOM 1495 C CD . GLU A 1 201 ? 37.338 -58.090 -11.162 1.00 40.70 ? 229 GLU A CD 1 ATOM 1496 O OE1 . GLU A 1 201 ? 38.406 -57.960 -11.822 1.00 43.13 ? 229 GLU A OE1 1 ATOM 1497 O OE2 . GLU A 1 201 ? 36.206 -57.904 -11.682 1.00 42.37 ? 229 GLU A OE2 1 ATOM 1498 N N . PRO A 1 202 ? 40.348 -58.439 -6.325 1.00 28.84 ? 230 PRO A N 1 ATOM 1499 C CA . PRO A 1 202 ? 41.593 -58.133 -5.607 1.00 28.21 ? 230 PRO A CA 1 ATOM 1500 C C . PRO A 1 202 ? 42.546 -57.365 -6.506 1.00 27.91 ? 230 PRO A C 1 ATOM 1501 O O . PRO A 1 202 ? 42.543 -57.584 -7.728 1.00 28.06 ? 230 PRO A O 1 ATOM 1502 C CB . PRO A 1 202 ? 42.189 -59.519 -5.299 1.00 28.29 ? 230 PRO A CB 1 ATOM 1503 C CG . PRO A 1 202 ? 41.188 -60.548 -5.832 1.00 28.97 ? 230 PRO A CG 1 ATOM 1504 C CD . PRO A 1 202 ? 40.321 -59.833 -6.816 1.00 28.76 ? 230 PRO A CD 1 ATOM 1505 N N . TYR A 1 203 ? 43.319 -56.449 -5.923 1.00 27.49 ? 231 TYR A N 1 ATOM 1506 C CA . TYR A 1 203 ? 44.422 -55.813 -6.629 1.00 27.82 ? 231 TYR A CA 1 ATOM 1507 C C . TYR A 1 203 ? 45.413 -56.898 -7.081 1.00 28.69 ? 231 TYR A C 1 ATOM 1508 O O . TYR A 1 203 ? 45.704 -57.810 -6.318 1.00 28.60 ? 231 TYR A O 1 ATOM 1509 C CB . TYR A 1 203 ? 45.125 -54.765 -5.747 1.00 26.88 ? 231 TYR A CB 1 ATOM 1510 C CG . TYR A 1 203 ? 44.339 -53.476 -5.541 1.00 26.31 ? 231 TYR A CG 1 ATOM 1511 C CD1 . TYR A 1 203 ? 43.450 -53.340 -4.483 1.00 25.47 ? 231 TYR A CD1 1 ATOM 1512 C CD2 . TYR A 1 203 ? 44.488 -52.394 -6.406 1.00 24.76 ? 231 TYR A CD2 1 ATOM 1513 C CE1 . TYR A 1 203 ? 42.719 -52.165 -4.294 1.00 24.82 ? 231 TYR A CE1 1 ATOM 1514 C CE2 . TYR A 1 203 ? 43.758 -51.219 -6.221 1.00 24.17 ? 231 TYR A CE2 1 ATOM 1515 C CZ . TYR A 1 203 ? 42.880 -51.113 -5.158 1.00 24.44 ? 231 TYR A CZ 1 ATOM 1516 O OH . TYR A 1 203 ? 42.165 -49.948 -4.950 1.00 23.97 ? 231 TYR A OH 1 ATOM 1517 N N . PRO A 1 204 ? 45.910 -56.814 -8.331 1.00 29.77 ? 232 PRO A N 1 ATOM 1518 C CA . PRO A 1 204 ? 46.977 -57.723 -8.784 1.00 30.91 ? 232 PRO A CA 1 ATOM 1519 C C . PRO A 1 204 ? 48.256 -57.518 -7.950 1.00 31.88 ? 232 PRO A C 1 ATOM 1520 O O . PRO A 1 204 ? 48.402 -56.473 -7.298 1.00 31.61 ? 232 PRO A O 1 ATOM 1521 C CB . PRO A 1 204 ? 47.222 -57.294 -10.243 1.00 31.00 ? 232 PRO A CB 1 ATOM 1522 C CG . PRO A 1 204 ? 46.082 -56.369 -10.602 1.00 30.97 ? 232 PRO A CG 1 ATOM 1523 C CD . PRO A 1 204 ? 45.598 -55.771 -9.325 1.00 29.90 ? 232 PRO A CD 1 ATOM 1524 N N . GLU A 1 205 ? 49.174 -58.486 -7.991 1.00 33.21 ? 233 GLU A N 1 ATOM 1525 C CA . GLU A 1 205 ? 50.359 -58.484 -7.120 1.00 34.56 ? 233 GLU A CA 1 ATOM 1526 C C . GLU A 1 205 ? 51.213 -57.217 -7.237 1.00 34.15 ? 233 GLU A C 1 ATOM 1527 O O . GLU A 1 205 ? 51.657 -56.666 -6.216 1.00 34.37 ? 233 GLU A O 1 ATOM 1528 C CB . GLU A 1 205 ? 51.190 -59.767 -7.308 1.00 35.35 ? 233 GLU A CB 1 ATOM 1529 C CG . GLU A 1 205 ? 52.474 -59.907 -6.424 1.00 41.46 ? 233 GLU A CG 1 ATOM 1530 C CD . GLU A 1 205 ? 52.263 -59.719 -4.878 1.00 49.71 ? 233 GLU A CD 1 ATOM 1531 O OE1 . GLU A 1 205 ? 51.175 -60.055 -4.309 1.00 52.82 ? 233 GLU A OE1 1 ATOM 1532 O OE2 . GLU A 1 205 ? 53.215 -59.223 -4.213 1.00 51.04 ? 233 GLU A OE2 1 ATOM 1533 N N . SER A 1 206 ? 51.397 -56.725 -8.458 1.00 33.47 ? 234 SER A N 1 ATOM 1534 C CA . SER A 1 206 ? 52.270 -55.583 -8.673 1.00 33.43 ? 234 SER A CA 1 ATOM 1535 C C . SER A 1 206 ? 51.671 -54.279 -8.149 1.00 32.97 ? 234 SER A C 1 ATOM 1536 O O . SER A 1 206 ? 52.389 -53.404 -7.675 1.00 32.71 ? 234 SER A O 1 ATOM 1537 C CB . SER A 1 206 ? 52.655 -55.447 -10.149 1.00 33.68 ? 234 SER A CB 1 ATOM 1538 O OG . SER A 1 206 ? 51.538 -55.052 -10.907 1.00 34.85 ? 234 SER A OG 1 ATOM 1539 N N . GLU A 1 207 ? 50.357 -54.149 -8.250 1.00 32.94 ? 235 GLU A N 1 ATOM 1540 C CA . GLU A 1 207 ? 49.648 -53.032 -7.647 1.00 32.93 ? 235 GLU A CA 1 ATOM 1541 C C . GLU A 1 207 ? 49.707 -53.075 -6.130 1.00 32.09 ? 235 GLU A C 1 ATOM 1542 O O . GLU A 1 207 ? 49.815 -52.028 -5.494 1.00 32.02 ? 235 GLU A O 1 ATOM 1543 C CB . GLU A 1 207 ? 48.194 -52.994 -8.103 1.00 33.77 ? 235 GLU A CB 1 ATOM 1544 C CG . GLU A 1 207 ? 47.963 -52.227 -9.414 1.00 38.15 ? 235 GLU A CG 1 ATOM 1545 C CD . GLU A 1 207 ? 48.414 -50.762 -9.330 1.00 43.27 ? 235 GLU A CD 1 ATOM 1546 O OE1 . GLU A 1 207 ? 48.009 -50.041 -8.369 1.00 43.63 ? 235 GLU A OE1 1 ATOM 1547 O OE2 . GLU A 1 207 ? 49.182 -50.343 -10.236 1.00 45.14 ? 235 GLU A OE2 1 ATOM 1548 N N . MET A 1 208 ? 49.623 -54.278 -5.555 1.00 31.03 ? 236 MET A N 1 ATOM 1549 C CA . MET A 1 208 ? 49.817 -54.460 -4.118 1.00 30.31 ? 236 MET A CA 1 ATOM 1550 C C . MET A 1 208 ? 51.231 -54.032 -3.673 1.00 30.26 ? 236 MET A C 1 ATOM 1551 O O . MET A 1 208 ? 51.396 -53.490 -2.580 1.00 30.06 ? 236 MET A O 1 ATOM 1552 C CB . MET A 1 208 ? 49.500 -55.895 -3.683 1.00 30.05 ? 236 MET A CB 1 ATOM 1553 C CG . MET A 1 208 ? 48.011 -56.267 -3.747 1.00 29.43 ? 236 MET A CG 1 ATOM 1554 S SD . MET A 1 208 ? 46.919 -55.424 -2.552 1.00 28.74 ? 236 MET A SD 1 ATOM 1555 C CE . MET A 1 208 ? 47.071 -56.470 -1.108 1.00 27.38 ? 236 MET A CE 1 ATOM 1556 N N . GLN A 1 209 ? 52.238 -54.236 -4.523 1.00 29.95 ? 237 GLN A N 1 ATOM 1557 C CA . GLN A 1 209 ? 53.574 -53.739 -4.218 1.00 30.18 ? 237 GLN A CA 1 ATOM 1558 C C . GLN A 1 209 ? 53.631 -52.207 -4.237 1.00 29.05 ? 237 GLN A C 1 ATOM 1559 O O . GLN A 1 209 ? 54.288 -51.596 -3.389 1.00 29.29 ? 237 GLN A O 1 ATOM 1560 C CB . GLN A 1 209 ? 54.637 -54.354 -5.130 1.00 30.80 ? 237 GLN A CB 1 ATOM 1561 C CG . GLN A 1 209 ? 55.092 -55.759 -4.697 1.00 36.04 ? 237 GLN A CG 1 ATOM 1562 C CD . GLN A 1 209 ? 55.728 -56.592 -5.855 1.00 43.19 ? 237 GLN A CD 1 ATOM 1563 O OE1 . GLN A 1 209 ? 55.577 -56.275 -7.055 1.00 45.33 ? 237 GLN A OE1 1 ATOM 1564 N NE2 . GLN A 1 209 ? 56.426 -57.668 -5.485 1.00 44.65 ? 237 GLN A NE2 1 ATOM 1565 N N . ARG A 1 210 ? 52.930 -51.578 -5.170 1.00 27.62 ? 238 ARG A N 1 ATOM 1566 C CA . ARG A 1 210 ? 52.863 -50.126 -5.148 1.00 26.83 ? 238 ARG A CA 1 ATOM 1567 C C . ARG A 1 210 ? 52.126 -49.653 -3.874 1.00 25.56 ? 238 ARG A C 1 ATOM 1568 O O . ARG A 1 210 ? 52.544 -48.673 -3.257 1.00 25.35 ? 238 ARG A O 1 ATOM 1569 C CB . ARG A 1 210 ? 52.303 -49.514 -6.458 1.00 27.15 ? 238 ARG A CB 1 ATOM 1570 C CG . ARG A 1 210 ? 52.923 -50.074 -7.777 1.00 30.38 ? 238 ARG A CG 1 ATOM 1571 C CD . ARG A 1 210 ? 53.103 -49.048 -8.938 1.00 36.36 ? 238 ARG A CD 1 ATOM 1572 N NE . ARG A 1 210 ? 51.968 -48.703 -9.851 1.00 40.31 ? 238 ARG A NE 1 ATOM 1573 C CZ . ARG A 1 210 ? 51.494 -49.449 -10.881 1.00 39.73 ? 238 ARG A CZ 1 ATOM 1574 N NH1 . ARG A 1 210 ? 51.953 -50.686 -11.113 1.00 39.00 ? 238 ARG A NH1 1 ATOM 1575 N NH2 . ARG A 1 210 ? 50.507 -48.977 -11.660 1.00 31.74 ? 238 ARG A NH2 1 ATOM 1576 N N . MET A 1 211 ? 51.074 -50.364 -3.454 1.00 24.09 ? 239 MET A N 1 ATOM 1577 C CA . MET A 1 211 ? 50.375 -50.021 -2.206 1.00 23.47 ? 239 MET A CA 1 ATOM 1578 C C . MET A 1 211 ? 51.319 -50.033 -0.993 1.00 22.80 ? 239 MET A C 1 ATOM 1579 O O . MET A 1 211 ? 51.388 -49.053 -0.249 1.00 22.43 ? 239 MET A O 1 ATOM 1580 C CB . MET A 1 211 ? 49.171 -50.932 -1.933 1.00 22.76 ? 239 MET A CB 1 ATOM 1581 C CG . MET A 1 211 ? 47.984 -50.686 -2.793 1.00 23.62 ? 239 MET A CG 1 ATOM 1582 S SD . MET A 1 211 ? 47.125 -49.126 -2.513 1.00 25.72 ? 239 MET A SD 1 ATOM 1583 C CE . MET A 1 211 ? 45.963 -49.218 -3.873 1.00 25.44 ? 239 MET A CE 1 ATOM 1584 N N . GLN A 1 212 ? 52.029 -51.148 -0.817 1.00 22.28 ? 240 GLN A N 1 ATOM 1585 C CA . GLN A 1 212 ? 52.999 -51.311 0.251 1.00 22.19 ? 240 GLN A CA 1 ATOM 1586 C C . GLN A 1 212 ? 53.955 -50.137 0.293 1.00 22.30 ? 240 GLN A C 1 ATOM 1587 O O . GLN A 1 212 ? 54.220 -49.611 1.384 1.00 22.79 ? 240 GLN A O 1 ATOM 1588 C CB . GLN A 1 212 ? 53.779 -52.634 0.105 1.00 22.48 ? 240 GLN A CB 1 ATOM 1589 C CG . GLN A 1 212 ? 54.716 -52.955 1.272 1.00 22.39 ? 240 GLN A CG 1 ATOM 1590 C CD . GLN A 1 212 ? 53.965 -53.185 2.586 1.00 23.88 ? 240 GLN A CD 1 ATOM 1591 O OE1 . GLN A 1 212 ? 53.494 -54.283 2.855 1.00 23.27 ? 240 GLN A OE1 1 ATOM 1592 N NE2 . GLN A 1 212 ? 53.851 -52.139 3.403 1.00 22.74 ? 240 GLN A NE2 1 ATOM 1593 N N . GLU A 1 213 ? 54.456 -49.713 -0.872 1.00 21.72 ? 241 GLU A N 1 ATOM 1594 C CA . GLU A 1 213 ? 55.348 -48.562 -0.932 1.00 22.17 ? 241 GLU A CA 1 ATOM 1595 C C . GLU A 1 213 ? 54.698 -47.302 -0.344 1.00 21.29 ? 241 GLU A C 1 ATOM 1596 O O . GLU A 1 213 ? 55.338 -46.593 0.453 1.00 21.51 ? 241 GLU A O 1 ATOM 1597 C CB . GLU A 1 213 ? 55.889 -48.318 -2.353 1.00 22.97 ? 241 GLU A CB 1 ATOM 1598 C CG . GLU A 1 213 ? 57.283 -48.927 -2.630 1.00 27.28 ? 241 GLU A CG 1 ATOM 1599 C CD . GLU A 1 213 ? 57.631 -49.120 -4.147 1.00 34.55 ? 241 GLU A CD 1 ATOM 1600 O OE1 . GLU A 1 213 ? 57.807 -48.121 -4.922 1.00 36.24 ? 241 GLU A OE1 1 ATOM 1601 O OE2 . GLU A 1 213 ? 57.772 -50.306 -4.551 1.00 36.76 ? 241 GLU A OE2 1 ATOM 1602 N N . LEU A 1 214 ? 53.437 -47.048 -0.708 1.00 20.10 ? 242 LEU A N 1 ATOM 1603 C CA . LEU A 1 214 ? 52.703 -45.856 -0.252 1.00 19.51 ? 242 LEU A CA 1 ATOM 1604 C C . LEU A 1 214 ? 52.403 -45.885 1.230 1.00 19.44 ? 242 LEU A C 1 ATOM 1605 O O . LEU A 1 214 ? 52.438 -44.840 1.896 1.00 18.83 ? 242 LEU A O 1 ATOM 1606 C CB . LEU A 1 214 ? 51.372 -45.670 -0.973 1.00 19.27 ? 242 LEU A CB 1 ATOM 1607 C CG . LEU A 1 214 ? 51.253 -45.495 -2.473 1.00 19.76 ? 242 LEU A CG 1 ATOM 1608 C CD1 . LEU A 1 214 ? 49.820 -45.187 -2.809 1.00 20.33 ? 242 LEU A CD1 1 ATOM 1609 C CD2 . LEU A 1 214 ? 52.159 -44.391 -2.967 1.00 22.86 ? 242 LEU A CD2 1 ATOM 1610 N N . ILE A 1 215 ? 52.063 -47.078 1.727 1.00 19.04 ? 243 ILE A N 1 ATOM 1611 C CA . ILE A 1 215 ? 51.860 -47.287 3.155 1.00 18.65 ? 243 ILE A CA 1 ATOM 1612 C C . ILE A 1 215 ? 53.137 -46.964 3.956 1.00 18.63 ? 243 ILE A C 1 ATOM 1613 O O . ILE A 1 215 ? 53.106 -46.203 4.929 1.00 18.07 ? 243 ILE A O 1 ATOM 1614 C CB . ILE A 1 215 ? 51.358 -48.696 3.412 1.00 18.15 ? 243 ILE A CB 1 ATOM 1615 C CG1 . ILE A 1 215 ? 49.954 -48.840 2.828 1.00 18.75 ? 243 ILE A CG1 1 ATOM 1616 C CG2 . ILE A 1 215 ? 51.334 -48.990 4.886 1.00 17.07 ? 243 ILE A CG2 1 ATOM 1617 C CD1 . ILE A 1 215 ? 49.552 -50.281 2.431 1.00 20.12 ? 243 ILE A CD1 1 ATOM 1618 N N . ASN A 1 216 ? 54.255 -47.517 3.503 1.00 19.25 ? 244 ASN A N 1 ATOM 1619 C CA . ASN A 1 216 ? 55.542 -47.308 4.142 1.00 19.89 ? 244 ASN A CA 1 ATOM 1620 C C . ASN A 1 216 ? 55.923 -45.827 4.177 1.00 20.00 ? 244 ASN A C 1 ATOM 1621 O O . ASN A 1 216 ? 56.336 -45.316 5.224 1.00 20.55 ? 244 ASN A O 1 ATOM 1622 C CB . ASN A 1 216 ? 56.627 -48.145 3.458 1.00 19.88 ? 244 ASN A CB 1 ATOM 1623 C CG . ASN A 1 216 ? 56.461 -49.660 3.708 1.00 21.75 ? 244 ASN A CG 1 ATOM 1624 O OD1 . ASN A 1 216 ? 55.698 -50.089 4.583 1.00 20.97 ? 244 ASN A OD1 1 ATOM 1625 N ND2 . ASN A 1 216 ? 57.189 -50.471 2.932 1.00 22.28 ? 244 ASN A ND2 1 ATOM 1626 N N . ALA A 1 217 ? 55.751 -45.145 3.042 1.00 19.93 ? 245 ALA A N 1 ATOM 1627 C CA . ALA A 1 217 ? 56.054 -43.731 2.921 1.00 19.37 ? 245 ALA A CA 1 ATOM 1628 C C . ALA A 1 217 ? 55.127 -42.917 3.806 1.00 19.55 ? 245 ALA A C 1 ATOM 1629 O O . ALA A 1 217 ? 55.545 -41.921 4.392 1.00 19.99 ? 245 ALA A O 1 ATOM 1630 C CB . ALA A 1 217 ? 55.957 -43.281 1.467 1.00 18.83 ? 245 ALA A CB 1 ATOM 1631 N N . SER A 1 218 ? 53.879 -43.350 3.928 1.00 19.88 ? 246 SER A N 1 ATOM 1632 C CA . SER A 1 218 ? 52.914 -42.670 4.784 1.00 20.84 ? 246 SER A CA 1 ATOM 1633 C C . SER A 1 218 ? 53.333 -42.709 6.242 1.00 21.82 ? 246 SER A C 1 ATOM 1634 O O . SER A 1 218 ? 53.339 -41.669 6.926 1.00 22.57 ? 246 SER A O 1 ATOM 1635 C CB . SER A 1 218 ? 51.528 -43.270 4.636 1.00 20.61 ? 246 SER A CB 1 ATOM 1636 O OG . SER A 1 218 ? 51.048 -43.024 3.334 1.00 21.86 ? 246 SER A OG 1 ATOM 1637 N N . ALA A 1 219 ? 53.677 -43.906 6.715 1.00 22.28 ? 247 ALA A N 1 ATOM 1638 C CA . ALA A 1 219 ? 54.189 -44.095 8.065 1.00 22.44 ? 247 ALA A CA 1 ATOM 1639 C C . ALA A 1 219 ? 55.433 -43.230 8.273 1.00 22.78 ? 247 ALA A C 1 ATOM 1640 O O . ALA A 1 219 ? 55.571 -42.584 9.304 1.00 23.19 ? 247 ALA A O 1 ATOM 1641 C CB . ALA A 1 219 ? 54.505 -45.562 8.301 1.00 22.06 ? 247 ALA A CB 1 ATOM 1642 N N . GLU A 1 220 ? 56.313 -43.211 7.275 1.00 23.18 ? 248 GLU A N 1 ATOM 1643 C CA . GLU A 1 220 ? 57.536 -42.409 7.309 1.00 24.16 ? 248 GLU A CA 1 ATOM 1644 C C . GLU A 1 220 ? 57.273 -40.910 7.526 1.00 22.32 ? 248 GLU A C 1 ATOM 1645 O O . GLU A 1 220 ? 58.111 -40.222 8.083 1.00 21.63 ? 248 GLU A O 1 ATOM 1646 C CB . GLU A 1 220 ? 58.391 -42.635 6.037 1.00 25.40 ? 248 GLU A CB 1 ATOM 1647 C CG . GLU A 1 220 ? 59.573 -43.630 6.230 1.00 32.59 ? 248 GLU A CG 1 ATOM 1648 C CD . GLU A 1 220 ? 60.351 -43.986 4.922 1.00 42.74 ? 248 GLU A CD 1 ATOM 1649 O OE1 . GLU A 1 220 ? 59.992 -43.483 3.805 1.00 44.28 ? 248 GLU A OE1 1 ATOM 1650 O OE2 . GLU A 1 220 ? 61.336 -44.787 5.026 1.00 46.10 ? 248 GLU A OE2 1 ATOM 1651 N N . ASN A 1 221 ? 56.106 -40.434 7.092 1.00 20.85 ? 249 ASN A N 1 ATOM 1652 C CA . ASN A 1 221 ? 55.775 -39.017 7.106 1.00 19.11 ? 249 ASN A CA 1 ATOM 1653 C C . ASN A 1 221 ? 54.595 -38.687 7.995 1.00 19.04 ? 249 ASN A C 1 ATOM 1654 O O . ASN A 1 221 ? 54.088 -37.559 7.969 1.00 18.21 ? 249 ASN A O 1 ATOM 1655 C CB . ASN A 1 221 ? 55.541 -38.520 5.695 1.00 18.92 ? 249 ASN A CB 1 ATOM 1656 C CG . ASN A 1 221 ? 56.804 -38.533 4.874 1.00 18.17 ? 249 ASN A CG 1 ATOM 1657 O OD1 . ASN A 1 221 ? 57.633 -37.636 4.968 1.00 20.24 ? 249 ASN A OD1 1 ATOM 1658 N ND2 . ASN A 1 221 ? 56.961 -39.557 4.069 1.00 16.87 ? 249 ASN A ND2 1 ATOM 1659 N N . LYS A 1 222 ? 54.190 -39.675 8.809 1.00 18.77 ? 250 LYS A N 1 ATOM 1660 C CA . LYS A 1 222 ? 53.152 -39.515 9.827 1.00 18.04 ? 250 LYS A CA 1 ATOM 1661 C C . LYS A 1 222 ? 51.797 -39.282 9.224 1.00 17.53 ? 250 LYS A C 1 ATOM 1662 O O . LYS A 1 222 ? 50.932 -38.694 9.849 1.00 17.55 ? 250 LYS A O 1 ATOM 1663 C CB . LYS A 1 222 ? 53.485 -38.363 10.760 1.00 18.37 ? 250 LYS A CB 1 ATOM 1664 C CG . LYS A 1 222 ? 54.694 -38.612 11.611 1.00 20.12 ? 250 LYS A CG 1 ATOM 1665 C CD . LYS A 1 222 ? 54.474 -39.845 12.483 1.00 21.36 ? 250 LYS A CD 1 ATOM 1666 C CE . LYS A 1 222 ? 55.654 -40.100 13.365 1.00 21.47 ? 250 LYS A CE 1 ATOM 1667 N NZ . LYS A 1 222 ? 55.563 -41.463 13.915 1.00 23.16 ? 250 LYS A NZ 1 ATOM 1668 N N . VAL A 1 223 ? 51.618 -39.762 8.003 1.00 17.10 ? 251 VAL A N 1 ATOM 1669 C CA . VAL A 1 223 ? 50.370 -39.615 7.295 1.00 16.34 ? 251 VAL A CA 1 ATOM 1670 C C . VAL A 1 223 ? 49.558 -40.886 7.504 1.00 16.73 ? 251 VAL A C 1 ATOM 1671 O O . VAL A 1 223 ? 50.083 -42.001 7.366 1.00 16.51 ? 251 VAL A O 1 ATOM 1672 C CB . VAL A 1 223 ? 50.651 -39.332 5.798 1.00 16.12 ? 251 VAL A CB 1 ATOM 1673 C CG1 . VAL A 1 223 ? 49.391 -39.396 4.967 1.00 14.81 ? 251 VAL A CG1 1 ATOM 1674 C CG2 . VAL A 1 223 ? 51.326 -37.956 5.641 1.00 15.99 ? 251 VAL A CG2 1 ATOM 1675 N N . ASP A 1 224 ? 48.286 -40.717 7.858 1.00 17.21 ? 252 ASP A N 1 ATOM 1676 C CA . ASP A 1 224 ? 47.355 -41.827 7.969 1.00 18.38 ? 252 ASP A CA 1 ATOM 1677 C C . ASP A 1 224 ? 46.828 -42.176 6.591 1.00 18.74 ? 252 ASP A C 1 ATOM 1678 O O . ASP A 1 224 ? 46.083 -41.402 5.988 1.00 19.70 ? 252 ASP A O 1 ATOM 1679 C CB . ASP A 1 224 ? 46.187 -41.448 8.862 1.00 18.78 ? 252 ASP A CB 1 ATOM 1680 C CG . ASP A 1 224 ? 46.605 -41.209 10.294 1.00 21.01 ? 252 ASP A CG 1 ATOM 1681 O OD1 . ASP A 1 224 ? 47.712 -41.666 10.673 1.00 22.90 ? 252 ASP A OD1 1 ATOM 1682 O OD2 . ASP A 1 224 ? 45.823 -40.569 11.048 1.00 23.70 ? 252 ASP A OD2 1 ATOM 1683 N N . PHE A 1 225 ? 47.242 -43.319 6.069 1.00 18.71 ? 253 PHE A N 1 ATOM 1684 C CA . PHE A 1 225 ? 46.789 -43.742 4.766 1.00 18.73 ? 253 PHE A CA 1 ATOM 1685 C C . PHE A 1 225 ? 45.424 -44.328 4.987 1.00 18.73 ? 253 PHE A C 1 ATOM 1686 O O . PHE A 1 225 ? 45.282 -45.306 5.724 1.00 19.27 ? 253 PHE A O 1 ATOM 1687 C CB . PHE A 1 225 ? 47.738 -44.808 4.205 1.00 18.95 ? 253 PHE A CB 1 ATOM 1688 C CG . PHE A 1 225 ? 47.343 -45.326 2.852 1.00 18.29 ? 253 PHE A CG 1 ATOM 1689 C CD1 . PHE A 1 225 ? 46.280 -46.223 2.708 1.00 17.94 ? 253 PHE A CD1 1 ATOM 1690 C CD2 . PHE A 1 225 ? 48.034 -44.926 1.723 1.00 16.67 ? 253 PHE A CD2 1 ATOM 1691 C CE1 . PHE A 1 225 ? 45.907 -46.697 1.442 1.00 16.81 ? 253 PHE A CE1 1 ATOM 1692 C CE2 . PHE A 1 225 ? 47.674 -45.406 0.465 1.00 17.02 ? 253 PHE A CE2 1 ATOM 1693 C CZ . PHE A 1 225 ? 46.603 -46.281 0.331 1.00 16.83 ? 253 PHE A CZ 1 ATOM 1694 N N . VAL A 1 226 ? 44.417 -43.718 4.379 1.00 18.89 ? 254 VAL A N 1 ATOM 1695 C CA . VAL A 1 226 ? 43.057 -44.226 4.487 1.00 18.60 ? 254 VAL A CA 1 ATOM 1696 C C . VAL A 1 226 ? 42.753 -44.954 3.202 1.00 19.18 ? 254 VAL A C 1 ATOM 1697 O O . VAL A 1 226 ? 42.818 -44.374 2.123 1.00 19.54 ? 254 VAL A O 1 ATOM 1698 C CB . VAL A 1 226 ? 42.014 -43.098 4.664 1.00 19.13 ? 254 VAL A CB 1 ATOM 1699 C CG1 . VAL A 1 226 ? 40.609 -43.706 4.928 1.00 16.89 ? 254 VAL A CG1 1 ATOM 1700 C CG2 . VAL A 1 226 ? 42.442 -42.083 5.758 1.00 16.81 ? 254 VAL A CG2 1 ATOM 1701 N N . PHE A 1 227 ? 42.424 -46.227 3.307 1.00 19.94 ? 255 PHE A N 1 ATOM 1702 C CA . PHE A 1 227 ? 42.003 -47.000 2.139 1.00 20.48 ? 255 PHE A CA 1 ATOM 1703 C C . PHE A 1 227 ? 40.497 -46.935 1.967 1.00 20.82 ? 255 PHE A C 1 ATOM 1704 O O . PHE A 1 227 ? 39.743 -47.458 2.790 1.00 20.67 ? 255 PHE A O 1 ATOM 1705 C CB . PHE A 1 227 ? 42.424 -48.453 2.294 1.00 20.39 ? 255 PHE A CB 1 ATOM 1706 C CG . PHE A 1 227 ? 42.004 -49.313 1.164 1.00 21.42 ? 255 PHE A CG 1 ATOM 1707 C CD1 . PHE A 1 227 ? 42.597 -49.175 -0.080 1.00 20.73 ? 255 PHE A CD1 1 ATOM 1708 C CD2 . PHE A 1 227 ? 41.006 -50.268 1.335 1.00 22.74 ? 255 PHE A CD2 1 ATOM 1709 C CE1 . PHE A 1 227 ? 42.224 -49.976 -1.135 1.00 21.65 ? 255 PHE A CE1 1 ATOM 1710 C CE2 . PHE A 1 227 ? 40.615 -51.075 0.274 1.00 21.68 ? 255 PHE A CE2 1 ATOM 1711 C CZ . PHE A 1 227 ? 41.230 -50.920 -0.967 1.00 22.70 ? 255 PHE A CZ 1 ATOM 1712 N N . GLY A 1 228 ? 40.067 -46.287 0.892 1.00 21.51 ? 256 GLY A N 1 ATOM 1713 C CA . GLY A 1 228 ? 38.647 -46.148 0.588 1.00 22.20 ? 256 GLY A CA 1 ATOM 1714 C C . GLY A 1 228 ? 38.170 -47.235 -0.358 1.00 22.78 ? 256 GLY A C 1 ATOM 1715 O O . GLY A 1 228 ? 38.950 -47.774 -1.140 1.00 22.80 ? 256 GLY A O 1 ATOM 1716 N N . ILE A 1 229 ? 36.883 -47.549 -0.278 1.00 23.04 ? 257 ILE A N 1 ATOM 1717 C CA . ILE A 1 229 ? 36.255 -48.490 -1.179 1.00 24.01 ? 257 ILE A CA 1 ATOM 1718 C C . ILE A 1 229 ? 34.861 -47.923 -1.459 1.00 24.53 ? 257 ILE A C 1 ATOM 1719 O O . ILE A 1 229 ? 34.258 -47.322 -0.560 1.00 24.84 ? 257 ILE A O 1 ATOM 1720 C CB . ILE A 1 229 ? 36.218 -49.923 -0.578 1.00 24.03 ? 257 ILE A CB 1 ATOM 1721 C CG1 . ILE A 1 229 ? 35.725 -50.947 -1.596 1.00 24.50 ? 257 ILE A CG1 1 ATOM 1722 C CG2 . ILE A 1 229 ? 35.315 -49.999 0.608 1.00 25.04 ? 257 ILE A CG2 1 ATOM 1723 C CD1 . ILE A 1 229 ? 36.854 -51.567 -2.396 1.00 27.27 ? 257 ILE A CD1 1 ATOM 1724 N N . SER A 1 230 ? 34.381 -48.059 -2.702 1.00 24.70 ? 258 SER A N 1 ATOM 1725 C CA . SER A 1 230 ? 33.073 -47.513 -3.128 1.00 25.24 ? 258 SER A CA 1 ATOM 1726 C C . SER A 1 230 ? 32.209 -48.587 -3.783 1.00 25.79 ? 258 SER A C 1 ATOM 1727 O O . SER A 1 230 ? 32.185 -48.713 -5.018 1.00 25.45 ? 258 SER A O 1 ATOM 1728 C CB . SER A 1 230 ? 33.236 -46.355 -4.104 1.00 24.84 ? 258 SER A CB 1 ATOM 1729 O OG . SER A 1 230 ? 33.595 -45.172 -3.433 1.00 26.11 ? 258 SER A OG 1 ATOM 1730 N N . PRO A 1 231 ? 31.488 -49.360 -2.953 1.00 26.33 ? 259 PRO A N 1 ATOM 1731 C CA . PRO A 1 231 ? 30.756 -50.516 -3.416 1.00 26.95 ? 259 PRO A CA 1 ATOM 1732 C C . PRO A 1 231 ? 29.287 -50.233 -3.792 1.00 27.58 ? 259 PRO A C 1 ATOM 1733 O O . PRO A 1 231 ? 28.568 -51.173 -4.148 1.00 27.98 ? 259 PRO A O 1 ATOM 1734 C CB . PRO A 1 231 ? 30.824 -51.445 -2.212 1.00 26.83 ? 259 PRO A CB 1 ATOM 1735 C CG . PRO A 1 231 ? 30.764 -50.527 -1.049 1.00 26.81 ? 259 PRO A CG 1 ATOM 1736 C CD . PRO A 1 231 ? 31.339 -49.187 -1.497 1.00 26.36 ? 259 PRO A CD 1 ATOM 1737 N N . GLY A 1 232 ? 28.856 -48.973 -3.746 1.00 28.09 ? 260 GLY A N 1 ATOM 1738 C CA . GLY A 1 232 ? 27.430 -48.651 -3.846 1.00 29.26 ? 260 GLY A CA 1 ATOM 1739 C C . GLY A 1 232 ? 26.732 -48.855 -5.192 1.00 30.46 ? 260 GLY A C 1 ATOM 1740 O O . GLY A 1 232 ? 25.490 -48.810 -5.274 1.00 31.27 ? 260 GLY A O 1 ATOM 1741 N N . ILE A 1 233 ? 27.513 -49.059 -6.250 1.00 30.59 ? 261 ILE A N 1 ATOM 1742 C CA . ILE A 1 233 ? 26.962 -49.292 -7.563 1.00 30.87 ? 261 ILE A CA 1 ATOM 1743 C C . ILE A 1 233 ? 26.136 -50.571 -7.596 1.00 31.02 ? 261 ILE A C 1 ATOM 1744 O O . ILE A 1 233 ? 25.019 -50.573 -8.100 1.00 31.05 ? 261 ILE A O 1 ATOM 1745 C CB . ILE A 1 233 ? 28.078 -49.279 -8.649 1.00 31.53 ? 261 ILE A CB 1 ATOM 1746 C CG1 . ILE A 1 233 ? 28.545 -47.831 -8.888 1.00 31.96 ? 261 ILE A CG1 1 ATOM 1747 C CG2 . ILE A 1 233 ? 27.616 -49.941 -9.979 1.00 31.52 ? 261 ILE A CG2 1 ATOM 1748 C CD1 . ILE A 1 233 ? 29.670 -47.694 -9.914 1.00 33.49 ? 261 ILE A CD1 1 ATOM 1749 N N . ASP A 1 234 ? 26.662 -51.660 -7.048 1.00 31.16 ? 262 ASP A N 1 ATOM 1750 C CA . ASP A 1 234 ? 26.024 -52.957 -7.258 1.00 31.21 ? 262 ASP A CA 1 ATOM 1751 C C . ASP A 1 234 ? 26.111 -53.933 -6.069 1.00 31.01 ? 262 ASP A C 1 ATOM 1752 O O . ASP A 1 234 ? 25.853 -55.125 -6.224 1.00 31.11 ? 262 ASP A O 1 ATOM 1753 C CB . ASP A 1 234 ? 26.602 -53.599 -8.524 1.00 31.16 ? 262 ASP A CB 1 ATOM 1754 C CG . ASP A 1 234 ? 28.102 -53.900 -8.402 1.00 33.30 ? 262 ASP A CG 1 ATOM 1755 O OD1 . ASP A 1 234 ? 28.619 -54.074 -7.267 1.00 35.43 ? 262 ASP A OD1 1 ATOM 1756 O OD2 . ASP A 1 234 ? 28.772 -53.986 -9.449 1.00 34.43 ? 262 ASP A OD2 1 ATOM 1757 N N . ILE A 1 235 ? 26.496 -53.435 -4.898 1.00 30.79 ? 263 ILE A N 1 ATOM 1758 C CA . ILE A 1 235 ? 26.512 -54.251 -3.694 1.00 30.26 ? 263 ILE A CA 1 ATOM 1759 C C . ILE A 1 235 ? 25.089 -54.691 -3.369 1.00 31.12 ? 263 ILE A C 1 ATOM 1760 O O . ILE A 1 235 ? 24.140 -53.894 -3.503 1.00 30.78 ? 263 ILE A O 1 ATOM 1761 C CB . ILE A 1 235 ? 27.127 -53.488 -2.483 1.00 30.02 ? 263 ILE A CB 1 ATOM 1762 C CG1 . ILE A 1 235 ? 27.311 -54.426 -1.290 1.00 29.42 ? 263 ILE A CG1 1 ATOM 1763 C CG2 . ILE A 1 235 ? 26.288 -52.258 -2.083 1.00 28.61 ? 263 ILE A CG2 1 ATOM 1764 C CD1 . ILE A 1 235 ? 27.910 -53.773 -0.048 1.00 25.98 ? 263 ILE A CD1 1 ATOM 1765 N N . ARG A 1 236 ? 24.955 -55.960 -2.962 1.00 32.00 ? 264 ARG A N 1 ATOM 1766 C CA . ARG A 1 236 ? 23.701 -56.539 -2.447 1.00 32.96 ? 264 ARG A CA 1 ATOM 1767 C C . ARG A 1 236 ? 23.686 -56.540 -0.913 1.00 33.61 ? 264 ARG A C 1 ATOM 1768 O O . ARG A 1 236 ? 24.710 -56.819 -0.268 1.00 34.40 ? 264 ARG A O 1 ATOM 1769 C CB . ARG A 1 236 ? 23.511 -57.976 -2.950 1.00 32.98 ? 264 ARG A CB 1 ATOM 1770 C CG . ARG A 1 236 ? 22.903 -58.117 -4.353 1.00 34.75 ? 264 ARG A CG 1 ATOM 1771 C CD . ARG A 1 236 ? 23.949 -58.344 -5.441 1.00 37.49 ? 264 ARG A CD 1 ATOM 1772 N NE . ARG A 1 236 ? 25.088 -59.144 -4.971 1.00 40.94 ? 264 ARG A NE 1 ATOM 1773 C CZ . ARG A 1 236 ? 25.362 -60.400 -5.339 1.00 43.19 ? 264 ARG A CZ 1 ATOM 1774 N NH1 . ARG A 1 236 ? 24.568 -61.046 -6.202 1.00 44.84 ? 264 ARG A NH1 1 ATOM 1775 N NH2 . ARG A 1 236 ? 26.435 -61.019 -4.834 1.00 41.78 ? 264 ARG A NH2 1 ATOM 1776 N N . PHE A 1 237 ? 22.521 -56.269 -0.330 1.00 33.99 ? 265 PHE A N 1 ATOM 1777 C CA . PHE A 1 237 ? 22.393 -56.158 1.119 1.00 34.10 ? 265 PHE A CA 1 ATOM 1778 C C . PHE A 1 237 ? 21.779 -57.341 1.843 1.00 34.52 ? 265 PHE A C 1 ATOM 1779 O O . PHE A 1 237 ? 22.081 -57.533 3.016 1.00 34.82 ? 265 PHE A O 1 ATOM 1780 C CB . PHE A 1 237 ? 21.598 -54.901 1.488 1.00 34.29 ? 265 PHE A CB 1 ATOM 1781 C CG . PHE A 1 237 ? 22.159 -53.642 0.903 1.00 34.87 ? 265 PHE A CG 1 ATOM 1782 C CD1 . PHE A 1 237 ? 23.344 -53.093 1.398 1.00 33.73 ? 265 PHE A CD1 1 ATOM 1783 C CD2 . PHE A 1 237 ? 21.517 -53.005 -0.160 1.00 34.98 ? 265 PHE A CD2 1 ATOM 1784 C CE1 . PHE A 1 237 ? 23.880 -51.924 0.848 1.00 32.91 ? 265 PHE A CE1 1 ATOM 1785 C CE2 . PHE A 1 237 ? 22.061 -51.829 -0.725 1.00 34.21 ? 265 PHE A CE2 1 ATOM 1786 C CZ . PHE A 1 237 ? 23.241 -51.295 -0.212 1.00 32.65 ? 265 PHE A CZ 1 ATOM 1787 N N . ASP A 1 238 ? 20.913 -58.122 1.186 1.00 34.96 ? 266 ASP A N 1 ATOM 1788 C CA . ASP A 1 238 ? 20.126 -59.163 1.906 1.00 35.04 ? 266 ASP A CA 1 ATOM 1789 C C . ASP A 1 238 ? 20.575 -60.600 1.650 1.00 33.77 ? 266 ASP A C 1 ATOM 1790 O O . ASP A 1 238 ? 21.189 -60.887 0.631 1.00 33.90 ? 266 ASP A O 1 ATOM 1791 C CB . ASP A 1 238 ? 18.618 -59.010 1.638 1.00 35.83 ? 266 ASP A CB 1 ATOM 1792 C CG . ASP A 1 238 ? 18.041 -57.740 2.249 1.00 39.37 ? 266 ASP A CG 1 ATOM 1793 O OD1 . ASP A 1 238 ? 18.769 -57.024 2.980 1.00 42.20 ? 266 ASP A OD1 1 ATOM 1794 O OD2 . ASP A 1 238 ? 16.847 -57.462 2.003 1.00 43.99 ? 266 ASP A OD2 1 ATOM 1795 N N . GLY A 1 239 ? 20.283 -61.488 2.600 1.00 32.64 ? 267 GLY A N 1 ATOM 1796 C CA . GLY A 1 239 ? 20.553 -62.919 2.462 1.00 31.36 ? 267 GLY A CA 1 ATOM 1797 C C . GLY A 1 239 ? 21.986 -63.302 2.148 1.00 30.86 ? 267 GLY A C 1 ATOM 1798 O O . GLY A 1 239 ? 22.921 -62.629 2.567 1.00 30.24 ? 267 GLY A O 1 ATOM 1799 N N . ASP A 1 240 ? 22.145 -64.395 1.404 1.00 30.62 ? 268 ASP A N 1 ATOM 1800 C CA . ASP A 1 240 ? 23.459 -64.947 1.095 1.00 30.60 ? 268 ASP A CA 1 ATOM 1801 C C . ASP A 1 240 ? 24.293 -64.031 0.192 1.00 30.12 ? 268 ASP A C 1 ATOM 1802 O O . ASP A 1 240 ? 25.523 -64.022 0.266 1.00 29.92 ? 268 ASP A O 1 ATOM 1803 C CB . ASP A 1 240 ? 23.340 -66.363 0.499 1.00 30.84 ? 268 ASP A CB 1 ATOM 1804 C CG . ASP A 1 240 ? 23.061 -67.453 1.569 1.00 33.79 ? 268 ASP A CG 1 ATOM 1805 O OD1 . ASP A 1 240 ? 23.483 -67.287 2.753 1.00 36.19 ? 268 ASP A OD1 1 ATOM 1806 O OD2 . ASP A 1 240 ? 22.415 -68.486 1.230 1.00 34.67 ? 268 ASP A OD2 1 ATOM 1807 N N . ALA A 1 241 ? 23.619 -63.257 -0.649 1.00 29.72 ? 269 ALA A N 1 ATOM 1808 C CA . ALA A 1 241 ? 24.305 -62.352 -1.544 1.00 29.41 ? 269 ALA A CA 1 ATOM 1809 C C . ALA A 1 241 ? 24.918 -61.228 -0.709 1.00 29.39 ? 269 ALA A C 1 ATOM 1810 O O . ALA A 1 241 ? 26.055 -60.818 -0.953 1.00 28.98 ? 269 ALA A O 1 ATOM 1811 C CB . ALA A 1 241 ? 23.354 -61.804 -2.589 1.00 29.02 ? 269 ALA A CB 1 ATOM 1812 N N . GLY A 1 242 ? 24.150 -60.763 0.282 1.00 29.16 ? 270 GLY A N 1 ATOM 1813 C CA . GLY A 1 242 ? 24.560 -59.705 1.196 1.00 28.88 ? 270 GLY A CA 1 ATOM 1814 C C . GLY A 1 242 ? 25.719 -60.123 2.069 1.00 28.96 ? 270 GLY A C 1 ATOM 1815 O O . GLY A 1 242 ? 26.631 -59.331 2.282 1.00 29.40 ? 270 GLY A O 1 ATOM 1816 N N . GLU A 1 243 ? 25.674 -61.355 2.575 1.00 28.91 ? 271 GLU A N 1 ATOM 1817 C CA . GLU A 1 243 ? 26.809 -61.990 3.236 1.00 29.91 ? 271 GLU A CA 1 ATOM 1818 C C . GLU A 1 243 ? 28.076 -61.934 2.396 1.00 29.49 ? 271 GLU A C 1 ATOM 1819 O O . GLU A 1 243 ? 29.127 -61.470 2.850 1.00 28.92 ? 271 GLU A O 1 ATOM 1820 C CB . GLU A 1 243 ? 26.532 -63.475 3.502 1.00 30.43 ? 271 GLU A CB 1 ATOM 1821 C CG . GLU A 1 243 ? 26.036 -63.803 4.890 1.00 35.70 ? 271 GLU A CG 1 ATOM 1822 C CD . GLU A 1 243 ? 26.781 -63.035 5.993 1.00 40.78 ? 271 GLU A CD 1 ATOM 1823 O OE1 . GLU A 1 243 ? 27.986 -63.349 6.248 1.00 40.97 ? 271 GLU A OE1 1 ATOM 1824 O OE2 . GLU A 1 243 ? 26.133 -62.116 6.576 1.00 41.66 ? 271 GLU A OE2 1 ATOM 1825 N N . GLU A 1 244 ? 27.952 -62.468 1.183 1.00 29.26 ? 272 GLU A N 1 ATOM 1826 C CA . GLU A 1 244 ? 29.057 -62.637 0.278 1.00 29.64 ? 272 GLU A CA 1 ATOM 1827 C C . GLU A 1 244 ? 29.624 -61.259 -0.069 1.00 29.41 ? 272 GLU A C 1 ATOM 1828 O O . GLU A 1 244 ? 30.846 -61.076 -0.075 1.00 29.87 ? 272 GLU A O 1 ATOM 1829 C CB . GLU A 1 244 ? 28.615 -63.415 -0.983 1.00 30.10 ? 272 GLU A CB 1 ATOM 1830 C CG . GLU A 1 244 ? 29.750 -63.975 -1.842 1.00 31.41 ? 272 GLU A CG 1 ATOM 1831 C CD . GLU A 1 244 ? 29.310 -64.343 -3.254 1.00 34.28 ? 272 GLU A CD 1 ATOM 1832 O OE1 . GLU A 1 244 ? 28.422 -65.205 -3.401 1.00 34.63 ? 272 GLU A OE1 1 ATOM 1833 O OE2 . GLU A 1 244 ? 29.860 -63.782 -4.234 1.00 35.59 ? 272 GLU A OE2 1 ATOM 1834 N N . ASP A 1 245 ? 28.746 -60.287 -0.307 1.00 28.36 ? 273 ASP A N 1 ATOM 1835 C CA . ASP A 1 245 ? 29.195 -58.966 -0.683 1.00 27.50 ? 273 ASP A CA 1 ATOM 1836 C C . ASP A 1 245 ? 29.855 -58.295 0.478 1.00 27.44 ? 273 ASP A C 1 ATOM 1837 O O . ASP A 1 245 ? 30.925 -57.703 0.323 1.00 27.57 ? 273 ASP A O 1 ATOM 1838 C CB . ASP A 1 245 ? 28.080 -58.119 -1.316 1.00 27.01 ? 273 ASP A CB 1 ATOM 1839 C CG . ASP A 1 245 ? 27.999 -58.337 -2.840 1.00 26.72 ? 273 ASP A CG 1 ATOM 1840 O OD1 . ASP A 1 245 ? 28.703 -59.250 -3.337 1.00 22.86 ? 273 ASP A OD1 1 ATOM 1841 O OD2 . ASP A 1 245 ? 27.248 -57.609 -3.537 1.00 26.27 ? 273 ASP A OD2 1 ATOM 1842 N N . PHE A 1 246 ? 29.249 -58.425 1.653 1.00 27.42 ? 274 PHE A N 1 ATOM 1843 C CA . PHE A 1 246 ? 29.903 -57.955 2.862 1.00 26.97 ? 274 PHE A CA 1 ATOM 1844 C C . PHE A 1 246 ? 31.311 -58.567 3.084 1.00 26.97 ? 274 PHE A C 1 ATOM 1845 O O . PHE A 1 246 ? 32.263 -57.841 3.385 1.00 27.33 ? 274 PHE A O 1 ATOM 1846 C CB . PHE A 1 246 ? 29.019 -58.140 4.092 1.00 26.49 ? 274 PHE A CB 1 ATOM 1847 C CG . PHE A 1 246 ? 29.605 -57.532 5.318 1.00 26.45 ? 274 PHE A CG 1 ATOM 1848 C CD1 . PHE A 1 246 ? 29.525 -56.159 5.523 1.00 24.98 ? 274 PHE A CD1 1 ATOM 1849 C CD2 . PHE A 1 246 ? 30.313 -58.324 6.242 1.00 26.15 ? 274 PHE A CD2 1 ATOM 1850 C CE1 . PHE A 1 246 ? 30.111 -55.586 6.653 1.00 26.14 ? 274 PHE A CE1 1 ATOM 1851 C CE2 . PHE A 1 246 ? 30.896 -57.756 7.373 1.00 24.58 ? 274 PHE A CE2 1 ATOM 1852 C CZ . PHE A 1 246 ? 30.798 -56.391 7.579 1.00 24.40 ? 274 PHE A CZ 1 ATOM 1853 N N . ASN A 1 247 ? 31.446 -59.883 2.930 1.00 26.87 ? 275 ASN A N 1 ATOM 1854 C CA . ASN A 1 247 ? 32.746 -60.542 3.079 1.00 27.22 ? 275 ASN A CA 1 ATOM 1855 C C . ASN A 1 247 ? 33.776 -60.087 2.029 1.00 27.28 ? 275 ASN A C 1 ATOM 1856 O O . ASN A 1 247 ? 34.972 -60.282 2.212 1.00 27.63 ? 275 ASN A O 1 ATOM 1857 C CB . ASN A 1 247 ? 32.599 -62.063 3.032 1.00 27.22 ? 275 ASN A CB 1 ATOM 1858 C CG . ASN A 1 247 ? 31.983 -62.651 4.301 1.00 29.27 ? 275 ASN A CG 1 ATOM 1859 O OD1 . ASN A 1 247 ? 31.902 -62.004 5.353 1.00 33.56 ? 275 ASN A OD1 1 ATOM 1860 N ND2 . ASN A 1 247 ? 31.570 -63.899 4.213 1.00 29.74 ? 275 ASN A ND2 1 ATOM 1861 N N . HIS A 1 248 ? 33.307 -59.511 0.920 1.00 27.10 ? 276 HIS A N 1 ATOM 1862 C CA . HIS A 1 248 ? 34.194 -58.968 -0.107 1.00 26.57 ? 276 HIS A CA 1 ATOM 1863 C C . HIS A 1 248 ? 34.841 -57.685 0.405 1.00 25.87 ? 276 HIS A C 1 ATOM 1864 O O . HIS A 1 248 ? 36.050 -57.492 0.218 1.00 26.00 ? 276 HIS A O 1 ATOM 1865 C CB . HIS A 1 248 ? 33.475 -58.733 -1.444 1.00 26.59 ? 276 HIS A CB 1 ATOM 1866 C CG . HIS A 1 248 ? 33.425 -59.942 -2.329 1.00 27.60 ? 276 HIS A CG 1 ATOM 1867 N ND1 . HIS A 1 248 ? 34.557 -60.633 -2.719 1.00 30.41 ? 276 HIS A ND1 1 ATOM 1868 C CD2 . HIS A 1 248 ? 32.378 -60.576 -2.916 1.00 28.07 ? 276 HIS A CD2 1 ATOM 1869 C CE1 . HIS A 1 248 ? 34.206 -61.653 -3.489 1.00 31.14 ? 276 HIS A CE1 1 ATOM 1870 N NE2 . HIS A 1 248 ? 32.889 -61.637 -3.629 1.00 30.07 ? 276 HIS A NE2 1 ATOM 1871 N N . LEU A 1 249 ? 34.051 -56.842 1.073 1.00 24.77 ? 277 LEU A N 1 ATOM 1872 C CA . LEU A 1 249 ? 34.591 -55.688 1.802 1.00 24.04 ? 277 LEU A CA 1 ATOM 1873 C C . LEU A 1 249 ? 35.629 -56.140 2.813 1.00 24.09 ? 277 LEU A C 1 ATOM 1874 O O . LEU A 1 249 ? 36.722 -55.596 2.815 1.00 24.22 ? 277 LEU A O 1 ATOM 1875 C CB . LEU A 1 249 ? 33.504 -54.888 2.512 1.00 23.73 ? 277 LEU A CB 1 ATOM 1876 C CG . LEU A 1 249 ? 32.459 -54.171 1.665 1.00 23.38 ? 277 LEU A CG 1 ATOM 1877 C CD1 . LEU A 1 249 ? 31.370 -53.542 2.548 1.00 23.74 ? 277 LEU A CD1 1 ATOM 1878 C CD2 . LEU A 1 249 ? 33.113 -53.108 0.835 1.00 23.38 ? 277 LEU A CD2 1 ATOM 1879 N N . ILE A 1 250 ? 35.311 -57.150 3.639 1.00 23.94 ? 278 ILE A N 1 ATOM 1880 C CA . ILE A 1 250 ? 36.264 -57.646 4.642 1.00 23.58 ? 278 ILE A CA 1 ATOM 1881 C C . ILE A 1 250 ? 37.555 -58.120 3.989 1.00 23.94 ? 278 ILE A C 1 ATOM 1882 O O . ILE A 1 250 ? 38.644 -57.736 4.401 1.00 24.22 ? 278 ILE A O 1 ATOM 1883 C CB . ILE A 1 250 ? 35.680 -58.767 5.583 1.00 23.48 ? 278 ILE A CB 1 ATOM 1884 C CG1 . ILE A 1 250 ? 34.431 -58.295 6.363 1.00 23.31 ? 278 ILE A CG1 1 ATOM 1885 C CG2 . ILE A 1 250 ? 36.741 -59.271 6.560 1.00 22.57 ? 278 ILE A CG2 1 ATOM 1886 C CD1 . ILE A 1 250 ? 34.587 -57.000 7.160 1.00 20.83 ? 278 ILE A CD1 1 ATOM 1887 N N . THR A 1 251 ? 37.435 -58.942 2.959 1.00 24.49 ? 279 THR A N 1 ATOM 1888 C CA . THR A 1 251 ? 38.611 -59.508 2.307 1.00 24.95 ? 279 THR A CA 1 ATOM 1889 C C . THR A 1 251 ? 39.495 -58.385 1.765 1.00 25.51 ? 279 THR A C 1 ATOM 1890 O O . THR A 1 251 ? 40.713 -58.400 1.922 1.00 25.65 ? 279 THR A O 1 ATOM 1891 C CB . THR A 1 251 ? 38.192 -60.480 1.183 1.00 24.93 ? 279 THR A CB 1 ATOM 1892 O OG1 . THR A 1 251 ? 37.515 -61.599 1.771 1.00 24.69 ? 279 THR A OG1 1 ATOM 1893 C CG2 . THR A 1 251 ? 39.404 -60.963 0.349 1.00 23.39 ? 279 THR A CG2 1 ATOM 1894 N N . LYS A 1 252 ? 38.862 -57.397 1.153 1.00 25.60 ? 280 LYS A N 1 ATOM 1895 C CA . LYS A 1 252 ? 39.599 -56.332 0.512 1.00 25.81 ? 280 LYS A CA 1 ATOM 1896 C C . LYS A 1 252 ? 40.292 -55.464 1.565 1.00 25.72 ? 280 LYS A C 1 ATOM 1897 O O . LYS A 1 252 ? 41.489 -55.234 1.472 1.00 26.41 ? 280 LYS A O 1 ATOM 1898 C CB . LYS A 1 252 ? 38.667 -55.527 -0.381 1.00 25.57 ? 280 LYS A CB 1 ATOM 1899 C CG . LYS A 1 252 ? 39.366 -54.761 -1.451 1.00 26.51 ? 280 LYS A CG 1 ATOM 1900 C CD . LYS A 1 252 ? 39.674 -55.610 -2.669 1.00 25.54 ? 280 LYS A CD 1 ATOM 1901 C CE . LYS A 1 252 ? 40.086 -54.705 -3.811 1.00 21.80 ? 280 LYS A CE 1 ATOM 1902 N NZ . LYS A 1 252 ? 38.900 -54.037 -4.428 1.00 23.06 ? 280 LYS A NZ 1 ATOM 1903 N N . ALA A 1 253 ? 39.550 -55.007 2.570 1.00 25.55 ? 281 ALA A N 1 ATOM 1904 C CA . ALA A 1 253 ? 40.130 -54.246 3.676 1.00 25.50 ? 281 ALA A CA 1 ATOM 1905 C C . ALA A 1 253 ? 41.202 -55.041 4.431 1.00 25.77 ? 281 ALA A C 1 ATOM 1906 O O . ALA A 1 253 ? 42.210 -54.469 4.846 1.00 26.43 ? 281 ALA A O 1 ATOM 1907 C CB . ALA A 1 253 ? 39.058 -53.760 4.617 1.00 25.02 ? 281 ALA A CB 1 ATOM 1908 N N . GLU A 1 254 ? 41.012 -56.354 4.574 1.00 25.43 ? 282 GLU A N 1 ATOM 1909 C CA . GLU A 1 254 ? 41.989 -57.199 5.261 1.00 25.09 ? 282 GLU A CA 1 ATOM 1910 C C . GLU A 1 254 ? 43.347 -57.194 4.565 1.00 24.81 ? 282 GLU A C 1 ATOM 1911 O O . GLU A 1 254 ? 44.387 -57.155 5.221 1.00 25.04 ? 282 GLU A O 1 ATOM 1912 C CB . GLU A 1 254 ? 41.468 -58.641 5.412 1.00 25.26 ? 282 GLU A CB 1 ATOM 1913 C CG . GLU A 1 254 ? 42.402 -59.608 6.171 1.00 25.96 ? 282 GLU A CG 1 ATOM 1914 C CD . GLU A 1 254 ? 42.513 -59.303 7.667 1.00 29.70 ? 282 GLU A CD 1 ATOM 1915 O OE1 . GLU A 1 254 ? 41.563 -58.684 8.210 1.00 31.42 ? 282 GLU A OE1 1 ATOM 1916 O OE2 . GLU A 1 254 ? 43.543 -59.675 8.299 1.00 29.82 ? 282 GLU A OE2 1 ATOM 1917 N N . SER A 1 255 ? 43.330 -57.246 3.240 1.00 24.48 ? 283 SER A N 1 ATOM 1918 C CA . SER A 1 255 ? 44.546 -57.396 2.459 1.00 24.10 ? 283 SER A CA 1 ATOM 1919 C C . SER A 1 255 ? 45.369 -56.114 2.544 1.00 23.79 ? 283 SER A C 1 ATOM 1920 O O . SER A 1 255 ? 46.593 -56.144 2.379 1.00 23.74 ? 283 SER A O 1 ATOM 1921 C CB . SER A 1 255 ? 44.225 -57.750 0.992 1.00 24.18 ? 283 SER A CB 1 ATOM 1922 O OG . SER A 1 255 ? 43.553 -56.675 0.346 1.00 24.34 ? 283 SER A OG 1 ATOM 1923 N N . LEU A 1 256 ? 44.684 -54.998 2.798 1.00 22.99 ? 284 LEU A N 1 ATOM 1924 C CA . LEU A 1 256 ? 45.365 -53.736 3.059 1.00 22.40 ? 284 LEU A CA 1 ATOM 1925 C C . LEU A 1 256 ? 45.783 -53.579 4.520 1.00 22.50 ? 284 LEU A C 1 ATOM 1926 O O . LEU A 1 256 ? 46.863 -53.044 4.807 1.00 23.26 ? 284 LEU A O 1 ATOM 1927 C CB . LEU A 1 256 ? 44.581 -52.539 2.522 1.00 21.61 ? 284 LEU A CB 1 ATOM 1928 C CG . LEU A 1 256 ? 45.012 -52.484 1.051 1.00 21.30 ? 284 LEU A CG 1 ATOM 1929 C CD1 . LEU A 1 256 ? 43.946 -53.032 0.076 1.00 22.21 ? 284 LEU A CD1 1 ATOM 1930 C CD2 . LEU A 1 256 ? 45.484 -51.137 0.643 1.00 18.72 ? 284 LEU A CD2 1 ATOM 1931 N N . TYR A 1 257 ? 44.960 -54.076 5.441 1.00 21.78 ? 285 TYR A N 1 ATOM 1932 C CA . TYR A 1 257 ? 45.358 -54.144 6.828 1.00 21.10 ? 285 TYR A CA 1 ATOM 1933 C C . TYR A 1 257 ? 46.680 -54.912 6.955 1.00 21.36 ? 285 TYR A C 1 ATOM 1934 O O . TYR A 1 257 ? 47.603 -54.493 7.656 1.00 21.41 ? 285 TYR A O 1 ATOM 1935 C CB . TYR A 1 257 ? 44.278 -54.811 7.664 1.00 20.46 ? 285 TYR A CB 1 ATOM 1936 C CG . TYR A 1 257 ? 44.597 -54.777 9.131 1.00 19.64 ? 285 TYR A CG 1 ATOM 1937 C CD1 . TYR A 1 257 ? 44.305 -53.645 9.905 1.00 18.66 ? 285 TYR A CD1 1 ATOM 1938 C CD2 . TYR A 1 257 ? 45.218 -55.861 9.748 1.00 19.81 ? 285 TYR A CD2 1 ATOM 1939 C CE1 . TYR A 1 257 ? 44.622 -53.606 11.245 1.00 19.79 ? 285 TYR A CE1 1 ATOM 1940 C CE2 . TYR A 1 257 ? 45.544 -55.838 11.111 1.00 19.84 ? 285 TYR A CE2 1 ATOM 1941 C CZ . TYR A 1 257 ? 45.245 -54.711 11.851 1.00 20.38 ? 285 TYR A CZ 1 ATOM 1942 O OH . TYR A 1 257 ? 45.556 -54.686 13.193 1.00 21.23 ? 285 TYR A OH 1 ATOM 1943 N N . ASP A 1 258 ? 46.769 -56.024 6.240 1.00 21.87 ? 286 ASP A N 1 ATOM 1944 C CA . ASP A 1 258 ? 47.910 -56.915 6.342 1.00 22.10 ? 286 ASP A CA 1 ATOM 1945 C C . ASP A 1 258 ? 49.198 -56.285 5.775 1.00 22.37 ? 286 ASP A C 1 ATOM 1946 O O . ASP A 1 258 ? 50.286 -56.776 6.013 1.00 22.55 ? 286 ASP A O 1 ATOM 1947 C CB . ASP A 1 258 ? 47.587 -58.268 5.707 1.00 21.79 ? 286 ASP A CB 1 ATOM 1948 C CG . ASP A 1 258 ? 46.664 -59.120 6.580 1.00 22.49 ? 286 ASP A CG 1 ATOM 1949 O OD1 . ASP A 1 258 ? 46.618 -58.924 7.806 1.00 21.33 ? 286 ASP A OD1 1 ATOM 1950 O OD2 . ASP A 1 258 ? 45.969 -60.008 6.043 1.00 24.07 ? 286 ASP A OD2 1 ATOM 1951 N N . MET A 1 259 ? 49.067 -55.172 5.061 1.00 22.54 ? 287 MET A N 1 ATOM 1952 C CA . MET A 1 259 ? 50.236 -54.424 4.613 1.00 22.37 ? 287 MET A CA 1 ATOM 1953 C C . MET A 1 259 ? 50.589 -53.233 5.513 1.00 21.72 ? 287 MET A C 1 ATOM 1954 O O . MET A 1 259 ? 51.642 -52.600 5.303 1.00 21.60 ? 287 MET A O 1 ATOM 1955 C CB . MET A 1 259 ? 50.038 -53.947 3.189 1.00 22.18 ? 287 MET A CB 1 ATOM 1956 C CG . MET A 1 259 ? 50.179 -55.043 2.182 1.00 24.07 ? 287 MET A CG 1 ATOM 1957 S SD . MET A 1 259 ? 49.755 -54.461 0.525 1.00 28.39 ? 287 MET A SD 1 ATOM 1958 C CE . MET A 1 259 ? 50.974 -55.478 -0.326 1.00 29.89 ? 287 MET A CE 1 ATOM 1959 N N . GLY A 1 260 ? 49.709 -52.929 6.480 1.00 20.57 ? 288 GLY A N 1 ATOM 1960 C CA . GLY A 1 260 ? 49.939 -51.853 7.456 1.00 19.46 ? 288 GLY A CA 1 ATOM 1961 C C . GLY A 1 260 ? 48.906 -50.723 7.519 1.00 18.91 ? 288 GLY A C 1 ATOM 1962 O O . GLY A 1 260 ? 49.101 -49.758 8.246 1.00 18.90 ? 288 GLY A O 1 ATOM 1963 N N . VAL A 1 261 ? 47.804 -50.831 6.776 1.00 18.07 ? 289 VAL A N 1 ATOM 1964 C CA . VAL A 1 261 ? 46.798 -49.766 6.760 1.00 16.71 ? 289 VAL A CA 1 ATOM 1965 C C . VAL A 1 261 ? 45.978 -49.824 8.031 1.00 17.08 ? 289 VAL A C 1 ATOM 1966 O O . VAL A 1 261 ? 45.587 -50.908 8.473 1.00 17.95 ? 289 VAL A O 1 ATOM 1967 C CB . VAL A 1 261 ? 45.877 -49.879 5.548 1.00 16.44 ? 289 VAL A CB 1 ATOM 1968 C CG1 . VAL A 1 261 ? 44.689 -48.941 5.675 1.00 14.61 ? 289 VAL A CG1 1 ATOM 1969 C CG2 . VAL A 1 261 ? 46.657 -49.600 4.277 1.00 14.99 ? 289 VAL A CG2 1 ATOM 1970 N N . ARG A 1 262 ? 45.726 -48.668 8.631 1.00 16.49 ? 290 ARG A N 1 ATOM 1971 C CA . ARG A 1 262 ? 44.966 -48.630 9.862 1.00 16.65 ? 290 ARG A CA 1 ATOM 1972 C C . ARG A 1 262 ? 43.813 -47.634 9.802 1.00 16.79 ? 290 ARG A C 1 ATOM 1973 O O . ARG A 1 262 ? 43.242 -47.281 10.850 1.00 16.49 ? 290 ARG A O 1 ATOM 1974 C CB . ARG A 1 262 ? 45.874 -48.362 11.079 1.00 17.04 ? 290 ARG A CB 1 ATOM 1975 C CG . ARG A 1 262 ? 46.947 -49.460 11.361 1.00 17.29 ? 290 ARG A CG 1 ATOM 1976 C CD . ARG A 1 262 ? 46.300 -50.763 11.779 1.00 17.39 ? 290 ARG A CD 1 ATOM 1977 N NE . ARG A 1 262 ? 47.270 -51.820 12.081 1.00 18.64 ? 290 ARG A NE 1 ATOM 1978 C CZ . ARG A 1 262 ? 47.779 -52.685 11.196 1.00 17.11 ? 290 ARG A CZ 1 ATOM 1979 N NH1 . ARG A 1 262 ? 47.458 -52.645 9.894 1.00 15.60 ? 290 ARG A NH1 1 ATOM 1980 N NH2 . ARG A 1 262 ? 48.633 -53.585 11.617 1.00 14.02 ? 290 ARG A NH2 1 ATOM 1981 N N . SER A 1 263 ? 43.464 -47.191 8.586 1.00 16.39 ? 291 SER A N 1 ATOM 1982 C CA . SER A 1 263 ? 42.285 -46.341 8.387 1.00 16.15 ? 291 SER A CA 1 ATOM 1983 C C . SER A 1 263 ? 41.521 -46.786 7.178 1.00 16.06 ? 291 SER A C 1 ATOM 1984 O O . SER A 1 263 ? 42.125 -47.140 6.157 1.00 16.55 ? 291 SER A O 1 ATOM 1985 C CB . SER A 1 263 ? 42.640 -44.865 8.245 1.00 15.83 ? 291 SER A CB 1 ATOM 1986 O OG . SER A 1 263 ? 43.102 -44.330 9.461 1.00 16.87 ? 291 SER A OG 1 ATOM 1987 N N . PHE A 1 264 ? 40.194 -46.777 7.281 1.00 15.53 ? 292 PHE A N 1 ATOM 1988 C CA . PHE A 1 264 ? 39.376 -47.218 6.166 1.00 15.69 ? 292 PHE A CA 1 ATOM 1989 C C . PHE A 1 264 ? 38.213 -46.287 5.912 1.00 16.40 ? 292 PHE A C 1 ATOM 1990 O O . PHE A 1 264 ? 37.710 -45.626 6.830 1.00 16.79 ? 292 PHE A O 1 ATOM 1991 C CB . PHE A 1 264 ? 38.935 -48.678 6.334 1.00 14.96 ? 292 PHE A CB 1 ATOM 1992 C CG . PHE A 1 264 ? 40.072 -49.604 6.535 1.00 13.99 ? 292 PHE A CG 1 ATOM 1993 C CD1 . PHE A 1 264 ? 40.644 -49.756 7.799 1.00 14.15 ? 292 PHE A CD1 1 ATOM 1994 C CD2 . PHE A 1 264 ? 40.613 -50.293 5.474 1.00 13.85 ? 292 PHE A CD2 1 ATOM 1995 C CE1 . PHE A 1 264 ? 41.728 -50.577 7.989 1.00 11.62 ? 292 PHE A CE1 1 ATOM 1996 C CE2 . PHE A 1 264 ? 41.696 -51.136 5.659 1.00 11.75 ? 292 PHE A CE2 1 ATOM 1997 C CZ . PHE A 1 264 ? 42.248 -51.269 6.923 1.00 12.93 ? 292 PHE A CZ 1 ATOM 1998 N N . ALA A 1 265 ? 37.802 -46.223 4.650 1.00 16.75 ? 293 ALA A N 1 ATOM 1999 C CA . ALA A 1 265 ? 36.640 -45.428 4.275 1.00 17.36 ? 293 ALA A CA 1 ATOM 2000 C C . ALA A 1 265 ? 35.740 -46.242 3.355 1.00 17.45 ? 293 ALA A C 1 ATOM 2001 O O . ALA A 1 265 ? 36.230 -46.903 2.445 1.00 17.93 ? 293 ALA A O 1 ATOM 2002 C CB . ALA A 1 265 ? 37.080 -44.135 3.593 1.00 16.74 ? 293 ALA A CB 1 ATOM 2003 N N . ILE A 1 266 ? 34.434 -46.183 3.590 1.00 17.63 ? 294 ILE A N 1 ATOM 2004 C CA . ILE A 1 266 ? 33.454 -46.803 2.696 1.00 18.09 ? 294 ILE A CA 1 ATOM 2005 C C . ILE A 1 266 ? 32.463 -45.734 2.226 1.00 18.80 ? 294 ILE A C 1 ATOM 2006 O O . ILE A 1 266 ? 31.742 -45.136 3.033 1.00 18.79 ? 294 ILE A O 1 ATOM 2007 C CB . ILE A 1 266 ? 32.725 -47.999 3.359 1.00 17.91 ? 294 ILE A CB 1 ATOM 2008 C CG1 . ILE A 1 266 ? 33.737 -49.072 3.771 1.00 18.24 ? 294 ILE A CG1 1 ATOM 2009 C CG2 . ILE A 1 266 ? 31.681 -48.604 2.411 1.00 17.05 ? 294 ILE A CG2 1 ATOM 2010 C CD1 . ILE A 1 266 ? 33.154 -50.223 4.614 1.00 18.16 ? 294 ILE A CD1 1 ATOM 2011 N N . TYR A 1 267 ? 32.449 -45.498 0.916 1.00 19.65 ? 295 TYR A N 1 ATOM 2012 C CA . TYR A 1 267 ? 31.737 -44.373 0.333 1.00 20.74 ? 295 TYR A CA 1 ATOM 2013 C C . TYR A 1 267 ? 30.497 -44.754 -0.458 1.00 21.68 ? 295 TYR A C 1 ATOM 2014 O O . TYR A 1 267 ? 30.491 -45.731 -1.215 1.00 22.03 ? 295 TYR A O 1 ATOM 2015 C CB . TYR A 1 267 ? 32.673 -43.609 -0.588 1.00 21.17 ? 295 TYR A CB 1 ATOM 2016 C CG . TYR A 1 267 ? 33.774 -42.824 0.112 1.00 21.26 ? 295 TYR A CG 1 ATOM 2017 C CD1 . TYR A 1 267 ? 33.570 -42.262 1.367 1.00 20.99 ? 295 TYR A CD1 1 ATOM 2018 C CD2 . TYR A 1 267 ? 35.008 -42.623 -0.504 1.00 21.40 ? 295 TYR A CD2 1 ATOM 2019 C CE1 . TYR A 1 267 ? 34.556 -41.514 1.990 1.00 21.62 ? 295 TYR A CE1 1 ATOM 2020 C CE2 . TYR A 1 267 ? 36.006 -41.875 0.113 1.00 21.46 ? 295 TYR A CE2 1 ATOM 2021 C CZ . TYR A 1 267 ? 35.772 -41.328 1.358 1.00 22.34 ? 295 TYR A CZ 1 ATOM 2022 O OH . TYR A 1 267 ? 36.744 -40.598 1.992 1.00 23.03 ? 295 TYR A OH 1 ATOM 2023 N N . TRP A 1 268 ? 29.458 -43.932 -0.298 1.00 22.67 ? 296 TRP A N 1 ATOM 2024 C CA . TRP A 1 268 ? 28.177 -44.129 -0.972 1.00 22.74 ? 296 TRP A CA 1 ATOM 2025 C C . TRP A 1 268 ? 27.800 -43.015 -1.957 1.00 23.23 ? 296 TRP A C 1 ATOM 2026 O O . TRP A 1 268 ? 26.669 -43.004 -2.425 1.00 24.18 ? 296 TRP A O 1 ATOM 2027 C CB . TRP A 1 268 ? 27.070 -44.270 0.072 1.00 22.10 ? 296 TRP A CB 1 ATOM 2028 C CG . TRP A 1 268 ? 27.360 -45.309 1.102 1.00 22.22 ? 296 TRP A CG 1 ATOM 2029 C CD1 . TRP A 1 268 ? 27.800 -45.095 2.382 1.00 21.54 ? 296 TRP A CD1 1 ATOM 2030 C CD2 . TRP A 1 268 ? 27.246 -46.735 0.951 1.00 21.50 ? 296 TRP A CD2 1 ATOM 2031 N NE1 . TRP A 1 268 ? 27.958 -46.295 3.030 1.00 21.39 ? 296 TRP A NE1 1 ATOM 2032 C CE2 . TRP A 1 268 ? 27.628 -47.315 2.177 1.00 20.69 ? 296 TRP A CE2 1 ATOM 2033 C CE3 . TRP A 1 268 ? 26.867 -47.576 -0.106 1.00 20.86 ? 296 TRP A CE3 1 ATOM 2034 C CZ2 . TRP A 1 268 ? 27.638 -48.700 2.381 1.00 21.18 ? 296 TRP A CZ2 1 ATOM 2035 C CZ3 . TRP A 1 268 ? 26.878 -48.953 0.100 1.00 20.24 ? 296 TRP A CZ3 1 ATOM 2036 C CH2 . TRP A 1 268 ? 27.262 -49.500 1.334 1.00 19.71 ? 296 TRP A CH2 1 ATOM 2037 N N . ASP A 1 269 ? 28.708 -42.082 -2.265 1.00 23.40 ? 297 ASP A N 1 ATOM 2038 C CA . ASP A 1 269 ? 28.368 -40.908 -3.116 1.00 23.45 ? 297 ASP A CA 1 ATOM 2039 C C . ASP A 1 269 ? 28.162 -41.241 -4.616 1.00 23.59 ? 297 ASP A C 1 ATOM 2040 O O . ASP A 1 269 ? 28.800 -42.154 -5.150 1.00 23.59 ? 297 ASP A O 1 ATOM 2041 C CB . ASP A 1 269 ? 29.417 -39.800 -2.962 1.00 23.15 ? 297 ASP A CB 1 ATOM 2042 C CG . ASP A 1 269 ? 30.802 -40.259 -3.356 1.00 24.56 ? 297 ASP A CG 1 ATOM 2043 O OD1 . ASP A 1 269 ? 31.208 -41.319 -2.850 1.00 25.74 ? 297 ASP A OD1 1 ATOM 2044 O OD2 . ASP A 1 269 ? 31.475 -39.583 -4.180 1.00 26.34 ? 297 ASP A OD2 1 ATOM 2045 N N . ASN A 1 270 ? 27.261 -40.509 -5.278 1.00 23.98 ? 298 ASN A N 1 ATOM 2046 C CA . ASN A 1 270 ? 27.033 -40.639 -6.731 1.00 24.96 ? 298 ASN A CA 1 ATOM 2047 C C . ASN A 1 270 ? 26.526 -42.000 -7.222 1.00 26.09 ? 298 ASN A C 1 ATOM 2048 O O . ASN A 1 270 ? 27.027 -42.537 -8.221 1.00 25.99 ? 298 ASN A O 1 ATOM 2049 C CB . ASN A 1 270 ? 28.299 -40.265 -7.511 1.00 24.46 ? 298 ASN A CB 1 ATOM 2050 C CG . ASN A 1 270 ? 28.644 -38.808 -7.384 1.00 23.48 ? 298 ASN A CG 1 ATOM 2051 O OD1 . ASN A 1 270 ? 27.906 -38.030 -6.774 1.00 22.31 ? 298 ASN A OD1 1 ATOM 2052 N ND2 . ASN A 1 270 ? 29.784 -38.427 -7.939 1.00 21.98 ? 298 ASN A ND2 1 ATOM 2053 N N . ILE A 1 271 ? 25.553 -42.568 -6.511 1.00 27.50 ? 299 ILE A N 1 ATOM 2054 C CA . ILE A 1 271 ? 25.017 -43.882 -6.861 1.00 28.53 ? 299 ILE A CA 1 ATOM 2055 C C . ILE A 1 271 ? 23.512 -43.785 -6.953 1.00 30.33 ? 299 ILE A C 1 ATOM 2056 O O . ILE A 1 271 ? 22.925 -42.838 -6.433 1.00 30.19 ? 299 ILE A O 1 ATOM 2057 C CB . ILE A 1 271 ? 25.400 -44.984 -5.850 1.00 27.93 ? 299 ILE A CB 1 ATOM 2058 C CG1 . ILE A 1 271 ? 24.899 -44.634 -4.445 1.00 26.49 ? 299 ILE A CG1 1 ATOM 2059 C CG2 . ILE A 1 271 ? 26.901 -45.271 -5.903 1.00 26.55 ? 299 ILE A CG2 1 ATOM 2060 C CD1 . ILE A 1 271 ? 25.086 -45.752 -3.428 1.00 22.85 ? 299 ILE A CD1 1 ATOM 2061 N N . GLN A 1 272 ? 22.898 -44.763 -7.617 1.00 32.32 ? 300 GLN A N 1 ATOM 2062 C CA . GLN A 1 272 ? 21.458 -44.756 -7.849 1.00 34.36 ? 300 GLN A CA 1 ATOM 2063 C C . GLN A 1 272 ? 20.696 -45.225 -6.605 1.00 34.39 ? 300 GLN A C 1 ATOM 2064 O O . GLN A 1 272 ? 19.658 -44.661 -6.251 1.00 34.52 ? 300 GLN A O 1 ATOM 2065 C CB . GLN A 1 272 ? 21.129 -45.651 -9.041 1.00 34.84 ? 300 GLN A CB 1 ATOM 2066 C CG . GLN A 1 272 ? 19.950 -45.168 -9.874 1.00 40.24 ? 300 GLN A CG 1 ATOM 2067 C CD . GLN A 1 272 ? 19.417 -46.263 -10.837 1.00 46.36 ? 300 GLN A CD 1 ATOM 2068 O OE1 . GLN A 1 272 ? 18.938 -47.321 -10.403 1.00 46.73 ? 300 GLN A OE1 1 ATOM 2069 N NE2 . GLN A 1 272 ? 19.511 -46.002 -12.150 1.00 47.78 ? 300 GLN A NE2 1 ATOM 2070 N N . ASP A 1 273 ? 21.237 -46.249 -5.941 1.00 34.76 ? 301 ASP A N 1 ATOM 2071 C CA . ASP A 1 273 ? 20.596 -46.877 -4.790 1.00 34.63 ? 301 ASP A CA 1 ATOM 2072 C C . ASP A 1 273 ? 20.587 -45.947 -3.593 1.00 34.40 ? 301 ASP A C 1 ATOM 2073 O O . ASP A 1 273 ? 21.635 -45.482 -3.149 1.00 34.40 ? 301 ASP A O 1 ATOM 2074 C CB . ASP A 1 273 ? 21.314 -48.188 -4.448 1.00 35.17 ? 301 ASP A CB 1 ATOM 2075 C CG . ASP A 1 273 ? 20.740 -48.878 -3.209 1.00 36.44 ? 301 ASP A CG 1 ATOM 2076 O OD1 . ASP A 1 273 ? 21.014 -48.416 -2.072 1.00 36.19 ? 301 ASP A OD1 1 ATOM 2077 O OD2 . ASP A 1 273 ? 20.029 -49.897 -3.385 1.00 37.77 ? 301 ASP A OD2 1 ATOM 2078 N N . LYS A 1 274 ? 19.397 -45.686 -3.065 1.00 34.03 ? 302 LYS A N 1 ATOM 2079 C CA . LYS A 1 274 ? 19.271 -44.802 -1.924 1.00 33.65 ? 302 LYS A CA 1 ATOM 2080 C C . LYS A 1 274 ? 18.700 -45.466 -0.651 1.00 33.57 ? 302 LYS A C 1 ATOM 2081 O O . LYS A 1 274 ? 18.016 -44.822 0.153 1.00 33.51 ? 302 LYS A O 1 ATOM 2082 C CB . LYS A 1 274 ? 18.525 -43.534 -2.327 1.00 33.56 ? 302 LYS A CB 1 ATOM 2083 C CG . LYS A 1 274 ? 19.368 -42.638 -3.230 1.00 34.73 ? 302 LYS A CG 1 ATOM 2084 C CD . LYS A 1 274 ? 18.806 -41.218 -3.437 1.00 35.11 ? 302 LYS A CD 1 ATOM 2085 C CE . LYS A 1 274 ? 18.626 -40.432 -2.134 1.00 34.34 ? 302 LYS A CE 1 ATOM 2086 N NZ . LYS A 1 274 ? 18.449 -38.950 -2.352 1.00 33.95 ? 302 LYS A NZ 1 ATOM 2087 N N . SER A 1 275 ? 19.030 -46.747 -0.460 1.00 33.26 ? 303 SER A N 1 ATOM 2088 C CA . SER A 1 275 ? 18.692 -47.502 0.761 1.00 33.08 ? 303 SER A CA 1 ATOM 2089 C C . SER A 1 275 ? 19.495 -47.044 2.000 1.00 32.96 ? 303 SER A C 1 ATOM 2090 O O . SER A 1 275 ? 20.447 -47.720 2.428 1.00 32.61 ? 303 SER A O 1 ATOM 2091 C CB . SER A 1 275 ? 18.927 -49.008 0.543 1.00 33.30 ? 303 SER A CB 1 ATOM 2092 O OG . SER A 1 275 ? 18.502 -49.426 -0.749 1.00 33.98 ? 303 SER A OG 1 ATOM 2093 N N . ALA A 1 276 ? 19.088 -45.914 2.582 1.00 32.74 ? 304 ALA A N 1 ATOM 2094 C CA . ALA A 1 276 ? 19.790 -45.299 3.713 1.00 32.81 ? 304 ALA A CA 1 ATOM 2095 C C . ALA A 1 276 ? 20.085 -46.253 4.851 1.00 32.98 ? 304 ALA A C 1 ATOM 2096 O O . ALA A 1 276 ? 21.185 -46.236 5.404 1.00 33.32 ? 304 ALA A O 1 ATOM 2097 C CB . ALA A 1 276 ? 19.025 -44.068 4.245 1.00 32.42 ? 304 ALA A CB 1 ATOM 2098 N N . ALA A 1 277 ? 19.102 -47.071 5.211 1.00 33.25 ? 305 ALA A N 1 ATOM 2099 C CA . ALA A 1 277 ? 19.249 -47.974 6.353 1.00 33.34 ? 305 ALA A CA 1 ATOM 2100 C C . ALA A 1 277 ? 20.278 -49.048 6.041 1.00 33.29 ? 305 ALA A C 1 ATOM 2101 O O . ALA A 1 277 ? 21.095 -49.405 6.904 1.00 33.50 ? 305 ALA A O 1 ATOM 2102 C CB . ALA A 1 277 ? 17.891 -48.607 6.767 1.00 33.36 ? 305 ALA A CB 1 ATOM 2103 N N . LYS A 1 278 ? 20.247 -49.556 4.808 1.00 32.73 ? 306 LYS A N 1 ATOM 2104 C CA . LYS A 1 278 ? 21.148 -50.636 4.430 1.00 32.22 ? 306 LYS A CA 1 ATOM 2105 C C . LYS A 1 278 ? 22.602 -50.172 4.321 1.00 31.22 ? 306 LYS A C 1 ATOM 2106 O O . LYS A 1 278 ? 23.521 -50.902 4.711 1.00 30.86 ? 306 LYS A O 1 ATOM 2107 C CB . LYS A 1 278 ? 20.644 -51.336 3.178 1.00 32.51 ? 306 LYS A CB 1 ATOM 2108 C CG . LYS A 1 278 ? 19.541 -52.347 3.521 1.00 34.51 ? 306 LYS A CG 1 ATOM 2109 C CD . LYS A 1 278 ? 18.561 -52.502 2.384 1.00 39.07 ? 306 LYS A CD 1 ATOM 2110 C CE . LYS A 1 278 ? 17.463 -53.477 2.739 1.00 41.42 ? 306 LYS A CE 1 ATOM 2111 N NZ . LYS A 1 278 ? 16.307 -53.305 1.804 1.00 44.62 ? 306 LYS A NZ 1 ATOM 2112 N N . HIS A 1 279 ? 22.780 -48.947 3.825 1.00 29.90 ? 307 HIS A N 1 ATOM 2113 C CA . HIS A 1 279 ? 24.076 -48.292 3.763 1.00 28.60 ? 307 HIS A CA 1 ATOM 2114 C C . HIS A 1 279 ? 24.639 -48.190 5.168 1.00 28.53 ? 307 HIS A C 1 ATOM 2115 O O . HIS A 1 279 ? 25.763 -48.622 5.433 1.00 29.09 ? 307 HIS A O 1 ATOM 2116 C CB . HIS A 1 279 ? 23.960 -46.890 3.142 1.00 28.31 ? 307 HIS A CB 1 ATOM 2117 C CG . HIS A 1 279 ? 23.568 -46.883 1.687 1.00 27.64 ? 307 HIS A CG 1 ATOM 2118 N ND1 . HIS A 1 279 ? 23.307 -45.716 0.993 1.00 26.43 ? 307 HIS A ND1 1 ATOM 2119 C CD2 . HIS A 1 279 ? 23.395 -47.893 0.800 1.00 24.69 ? 307 HIS A CD2 1 ATOM 2120 C CE1 . HIS A 1 279 ? 22.998 -46.010 -0.257 1.00 26.27 ? 307 HIS A CE1 1 ATOM 2121 N NE2 . HIS A 1 279 ? 23.045 -47.323 -0.398 1.00 27.01 ? 307 HIS A NE2 1 ATOM 2122 N N . ALA A 1 280 ? 23.851 -47.646 6.088 1.00 27.99 ? 308 ALA A N 1 ATOM 2123 C CA . ALA A 1 280 ? 24.321 -47.451 7.457 1.00 27.18 ? 308 ALA A CA 1 ATOM 2124 C C . ALA A 1 280 ? 24.560 -48.768 8.167 1.00 27.07 ? 308 ALA A C 1 ATOM 2125 O O . ALA A 1 280 ? 25.432 -48.849 9.028 1.00 27.73 ? 308 ALA A O 1 ATOM 2126 C CB . ALA A 1 280 ? 23.363 -46.594 8.237 1.00 26.86 ? 308 ALA A CB 1 ATOM 2127 N N . GLN A 1 281 ? 23.814 -49.806 7.795 1.00 26.66 ? 309 GLN A N 1 ATOM 2128 C CA . GLN A 1 281 ? 23.939 -51.090 8.464 1.00 26.30 ? 309 GLN A CA 1 ATOM 2129 C C . GLN A 1 281 ? 25.280 -51.714 8.084 1.00 26.35 ? 309 GLN A C 1 ATOM 2130 O O . GLN A 1 281 ? 25.986 -52.272 8.940 1.00 27.13 ? 309 GLN A O 1 ATOM 2131 C CB . GLN A 1 281 ? 22.729 -52.012 8.189 1.00 26.12 ? 309 GLN A CB 1 ATOM 2132 C CG . GLN A 1 281 ? 21.452 -51.703 9.041 1.00 25.46 ? 309 GLN A CG 1 ATOM 2133 C CD . GLN A 1 281 ? 20.267 -52.585 8.676 0.010 25.59 ? 309 GLN A CD 1 ATOM 2134 O OE1 . GLN A 1 281 ? 19.169 -52.091 8.423 0.010 25.49 ? 309 GLN A OE1 1 ATOM 2135 N NE2 . GLN A 1 281 ? 20.487 -53.896 8.647 0.010 25.55 ? 309 GLN A NE2 1 ATOM 2136 N N . VAL A 1 282 ? 25.658 -51.563 6.815 1.00 25.63 ? 310 VAL A N 1 ATOM 2137 C CA . VAL A 1 282 ? 26.934 -52.066 6.320 1.00 24.70 ? 310 VAL A CA 1 ATOM 2138 C C . VAL A 1 282 ? 28.076 -51.423 7.106 1.00 24.38 ? 310 VAL A C 1 ATOM 2139 O O . VAL A 1 282 ? 28.998 -52.115 7.563 1.00 24.94 ? 310 VAL A O 1 ATOM 2140 C CB . VAL A 1 282 ? 27.100 -51.813 4.795 1.00 24.60 ? 310 VAL A CB 1 ATOM 2141 C CG1 . VAL A 1 282 ? 28.547 -51.942 4.375 1.00 23.57 ? 310 VAL A CG1 1 ATOM 2142 C CG2 . VAL A 1 282 ? 26.252 -52.780 4.010 1.00 24.00 ? 310 VAL A CG2 1 ATOM 2143 N N . LEU A 1 283 ? 27.987 -50.111 7.276 1.00 23.57 ? 311 LEU A N 1 ATOM 2144 C CA . LEU A 1 283 ? 28.971 -49.348 8.026 1.00 23.74 ? 311 LEU A CA 1 ATOM 2145 C C . LEU A 1 283 ? 29.153 -49.864 9.453 1.00 24.19 ? 311 LEU A C 1 ATOM 2146 O O . LEU A 1 283 ? 30.289 -50.174 9.863 1.00 23.42 ? 311 LEU A O 1 ATOM 2147 C CB . LEU A 1 283 ? 28.633 -47.846 8.022 1.00 23.25 ? 311 LEU A CB 1 ATOM 2148 C CG . LEU A 1 283 ? 28.797 -47.242 6.625 1.00 22.44 ? 311 LEU A CG 1 ATOM 2149 C CD1 . LEU A 1 283 ? 28.328 -45.799 6.578 1.00 21.13 ? 311 LEU A CD1 1 ATOM 2150 C CD2 . LEU A 1 283 ? 30.233 -47.401 6.139 1.00 21.31 ? 311 LEU A CD2 1 ATOM 2151 N N . ASN A 1 284 ? 28.031 -49.978 10.176 1.00 24.67 ? 312 ASN A N 1 ATOM 2152 C CA . ASN A 1 284 ? 28.034 -50.435 11.562 1.00 25.32 ? 312 ASN A CA 1 ATOM 2153 C C . ASN A 1 284 ? 28.584 -51.839 11.700 1.00 25.97 ? 312 ASN A C 1 ATOM 2154 O O . ASN A 1 284 ? 29.250 -52.166 12.689 1.00 26.72 ? 312 ASN A O 1 ATOM 2155 C CB . ASN A 1 284 ? 26.629 -50.396 12.149 1.00 25.08 ? 312 ASN A CB 1 ATOM 2156 C CG . ASN A 1 284 ? 26.037 -48.996 12.171 1.00 25.62 ? 312 ASN A CG 1 ATOM 2157 O OD1 . ASN A 1 284 ? 26.748 -47.988 12.092 1.00 25.28 ? 312 ASN A OD1 1 ATOM 2158 N ND2 . ASN A 1 284 ? 24.715 -48.928 12.280 1.00 25.04 ? 312 ASN A ND2 1 ATOM 2159 N N . ARG A 1 285 ? 28.313 -52.671 10.708 1.00 26.43 ? 313 ARG A N 1 ATOM 2160 C CA . ARG A 1 285 ? 28.714 -54.055 10.774 1.00 27.28 ? 313 ARG A CA 1 ATOM 2161 C C . ARG A 1 285 ? 30.219 -54.151 10.590 1.00 27.26 ? 313 ARG A C 1 ATOM 2162 O O . ARG A 1 285 ? 30.908 -54.887 11.303 1.00 27.76 ? 313 ARG A O 1 ATOM 2163 C CB . ARG A 1 285 ? 27.993 -54.818 9.690 1.00 27.73 ? 313 ARG A CB 1 ATOM 2164 C CG . ARG A 1 285 ? 27.631 -56.194 10.100 1.00 30.75 ? 313 ARG A CG 1 ATOM 2165 C CD . ARG A 1 285 ? 27.148 -57.000 8.907 1.00 34.56 ? 313 ARG A CD 1 ATOM 2166 N NE . ARG A 1 285 ? 27.823 -58.286 8.946 1.00 36.89 ? 313 ARG A NE 1 ATOM 2167 C CZ . ARG A 1 285 ? 27.563 -59.328 8.162 1.00 37.48 ? 313 ARG A CZ 1 ATOM 2168 N NH1 . ARG A 1 285 ? 26.611 -59.270 7.237 1.00 36.53 ? 313 ARG A NH1 1 ATOM 2169 N NH2 . ARG A 1 285 ? 28.275 -60.443 8.319 1.00 39.02 ? 313 ARG A NH2 1 ATOM 2170 N N . PHE A 1 286 ? 30.726 -53.368 9.645 1.00 27.11 ? 314 PHE A N 1 ATOM 2171 C CA . PHE A 1 286 ? 32.152 -53.262 9.385 1.00 26.58 ? 314 PHE A CA 1 ATOM 2172 C C . PHE A 1 286 ? 32.863 -52.621 10.576 1.00 26.58 ? 314 PHE A C 1 ATOM 2173 O O . PHE A 1 286 ? 33.961 -53.029 10.953 1.00 26.65 ? 314 PHE A O 1 ATOM 2174 C CB . PHE A 1 286 ? 32.344 -52.420 8.128 1.00 26.45 ? 314 PHE A CB 1 ATOM 2175 C CG . PHE A 1 286 ? 33.752 -52.394 7.612 1.00 25.46 ? 314 PHE A CG 1 ATOM 2176 C CD1 . PHE A 1 286 ? 34.195 -53.367 6.711 1.00 23.95 ? 314 PHE A CD1 1 ATOM 2177 C CD2 . PHE A 1 286 ? 34.621 -51.376 7.990 1.00 24.04 ? 314 PHE A CD2 1 ATOM 2178 C CE1 . PHE A 1 286 ? 35.483 -53.331 6.213 1.00 22.38 ? 314 PHE A CE1 1 ATOM 2179 C CE2 . PHE A 1 286 ? 35.909 -51.339 7.486 1.00 24.17 ? 314 PHE A CE2 1 ATOM 2180 C CZ . PHE A 1 286 ? 36.340 -52.321 6.600 1.00 22.08 ? 314 PHE A CZ 1 ATOM 2181 N N . ASN A 1 287 ? 32.227 -51.607 11.155 1.00 26.71 ? 315 ASN A N 1 ATOM 2182 C CA . ASN A 1 287 ? 32.705 -50.994 12.366 1.00 27.18 ? 315 ASN A CA 1 ATOM 2183 C C . ASN A 1 287 ? 32.883 -52.020 13.496 1.00 28.34 ? 315 ASN A C 1 ATOM 2184 O O . ASN A 1 287 ? 33.894 -52.001 14.185 1.00 28.63 ? 315 ASN A O 1 ATOM 2185 C CB . ASN A 1 287 ? 31.752 -49.899 12.785 1.00 26.78 ? 315 ASN A CB 1 ATOM 2186 C CG . ASN A 1 287 ? 32.420 -48.849 13.636 1.00 27.00 ? 315 ASN A CG 1 ATOM 2187 O OD1 . ASN A 1 287 ? 33.599 -48.534 13.439 1.00 26.92 ? 315 ASN A OD1 1 ATOM 2188 N ND2 . ASN A 1 287 ? 31.679 -48.301 14.598 1.00 24.75 ? 315 ASN A ND2 1 ATOM 2189 N N . GLU A 1 288 ? 31.931 -52.937 13.656 1.00 29.62 ? 316 GLU A N 1 ATOM 2190 C CA . GLU A 1 288 ? 32.010 -53.966 14.699 1.00 31.04 ? 316 GLU A CA 1 ATOM 2191 C C . GLU A 1 288 ? 32.881 -55.168 14.336 1.00 30.57 ? 316 GLU A C 1 ATOM 2192 O O . GLU A 1 288 ? 33.676 -55.608 15.148 1.00 30.99 ? 316 GLU A O 1 ATOM 2193 C CB . GLU A 1 288 ? 30.611 -54.415 15.148 1.00 31.83 ? 316 GLU A CB 1 ATOM 2194 C CG . GLU A 1 288 ? 30.082 -53.681 16.413 1.00 37.83 ? 316 GLU A CG 1 ATOM 2195 C CD . GLU A 1 288 ? 30.156 -54.552 17.710 1.00 45.28 ? 316 GLU A CD 1 ATOM 2196 O OE1 . GLU A 1 288 ? 29.431 -55.586 17.792 1.00 46.81 ? 316 GLU A OE1 1 ATOM 2197 O OE2 . GLU A 1 288 ? 30.917 -54.192 18.656 1.00 46.75 ? 316 GLU A OE2 1 ATOM 2198 N N . GLU A 1 289 ? 32.745 -55.716 13.137 1.00 30.23 ? 317 GLU A N 1 ATOM 2199 C CA . GLU A 1 289 ? 33.498 -56.931 12.801 1.00 29.76 ? 317 GLU A CA 1 ATOM 2200 C C . GLU A 1 289 ? 34.918 -56.652 12.343 1.00 28.76 ? 317 GLU A C 1 ATOM 2201 O O . GLU A 1 289 ? 35.733 -57.570 12.286 1.00 28.66 ? 317 GLU A O 1 ATOM 2202 C CB . GLU A 1 289 ? 32.777 -57.757 11.741 1.00 30.06 ? 317 GLU A CB 1 ATOM 2203 C CG . GLU A 1 289 ? 31.497 -58.421 12.245 1.00 33.40 ? 317 GLU A CG 1 ATOM 2204 C CD . GLU A 1 289 ? 30.832 -59.302 11.197 1.00 36.24 ? 317 GLU A CD 1 ATOM 2205 O OE1 . GLU A 1 289 ? 31.559 -60.019 10.455 1.00 37.21 ? 317 GLU A OE1 1 ATOM 2206 O OE2 . GLU A 1 289 ? 29.580 -59.270 11.126 1.00 36.47 ? 317 GLU A OE2 1 ATOM 2207 N N . PHE A 1 290 ? 35.215 -55.392 12.020 1.00 27.33 ? 318 PHE A N 1 ATOM 2208 C CA . PHE A 1 290 ? 36.543 -55.043 11.536 1.00 25.92 ? 318 PHE A CA 1 ATOM 2209 C C . PHE A 1 290 ? 37.258 -53.977 12.382 1.00 25.93 ? 318 PHE A C 1 ATOM 2210 O O . PHE A 1 290 ? 38.254 -54.268 13.038 1.00 26.17 ? 318 PHE A O 1 ATOM 2211 C CB . PHE A 1 290 ? 36.487 -54.630 10.066 1.00 25.41 ? 318 PHE A CB 1 ATOM 2212 C CG . PHE A 1 290 ? 37.831 -54.501 9.435 1.00 22.72 ? 318 PHE A CG 1 ATOM 2213 C CD1 . PHE A 1 290 ? 38.444 -55.600 8.856 1.00 19.54 ? 318 PHE A CD1 1 ATOM 2214 C CD2 . PHE A 1 290 ? 38.497 -53.276 9.429 1.00 20.41 ? 318 PHE A CD2 1 ATOM 2215 C CE1 . PHE A 1 290 ? 39.711 -55.481 8.269 1.00 20.57 ? 318 PHE A CE1 1 ATOM 2216 C CE2 . PHE A 1 290 ? 39.764 -53.146 8.851 1.00 19.34 ? 318 PHE A CE2 1 ATOM 2217 C CZ . PHE A 1 290 ? 40.377 -54.243 8.269 1.00 18.88 ? 318 PHE A CZ 1 ATOM 2218 N N . VAL A 1 291 ? 36.761 -52.746 12.362 1.00 25.73 ? 319 VAL A N 1 ATOM 2219 C CA . VAL A 1 291 ? 37.427 -51.651 13.047 1.00 25.35 ? 319 VAL A CA 1 ATOM 2220 C C . VAL A 1 291 ? 37.612 -51.921 14.543 1.00 25.85 ? 319 VAL A C 1 ATOM 2221 O O . VAL A 1 291 ? 38.725 -51.837 15.060 1.00 25.64 ? 319 VAL A O 1 ATOM 2222 C CB . VAL A 1 291 ? 36.683 -50.330 12.815 1.00 25.39 ? 319 VAL A CB 1 ATOM 2223 C CG1 . VAL A 1 291 ? 37.318 -49.205 13.595 1.00 24.71 ? 319 VAL A CG1 1 ATOM 2224 C CG2 . VAL A 1 291 ? 36.669 -49.983 11.331 1.00 25.53 ? 319 VAL A CG2 1 ATOM 2225 N N . LYS A 1 292 ? 36.538 -52.270 15.239 1.00 26.33 ? 320 LYS A N 1 ATOM 2226 C CA . LYS A 1 292 ? 36.655 -52.521 16.670 1.00 27.26 ? 320 LYS A CA 1 ATOM 2227 C C . LYS A 1 292 ? 37.392 -53.810 16.984 1.00 26.75 ? 320 LYS A C 1 ATOM 2228 O O . LYS A 1 292 ? 38.222 -53.831 17.890 1.00 26.79 ? 320 LYS A O 1 ATOM 2229 C CB . LYS A 1 292 ? 35.299 -52.441 17.380 1.00 28.17 ? 320 LYS A CB 1 ATOM 2230 C CG . LYS A 1 292 ? 34.770 -50.997 17.375 1.00 32.22 ? 320 LYS A CG 1 ATOM 2231 C CD . LYS A 1 292 ? 33.363 -50.803 18.010 1.00 38.45 ? 320 LYS A CD 1 ATOM 2232 C CE . LYS A 1 292 ? 32.879 -49.345 17.753 1.00 40.97 ? 320 LYS A CE 1 ATOM 2233 N NZ . LYS A 1 292 ? 31.672 -48.939 18.541 1.00 43.50 ? 320 LYS A NZ 1 ATOM 2234 N N . ALA A 1 293 ? 37.130 -54.871 16.213 1.00 26.11 ? 321 ALA A N 1 ATOM 2235 C CA . ALA A 1 293 ? 37.799 -56.173 16.431 1.00 24.70 ? 321 ALA A CA 1 ATOM 2236 C C . ALA A 1 293 ? 39.315 -56.047 16.367 1.00 23.91 ? 321 ALA A C 1 ATOM 2237 O O . ALA A 1 293 ? 40.028 -56.614 17.211 1.00 23.95 ? 321 ALA A O 1 ATOM 2238 C CB . ALA A 1 293 ? 37.307 -57.220 15.453 1.00 24.28 ? 321 ALA A CB 1 ATOM 2239 N N . LYS A 1 294 ? 39.793 -55.291 15.380 1.00 22.57 ? 322 LYS A N 1 ATOM 2240 C CA . LYS A 1 294 ? 41.223 -55.103 15.181 1.00 21.89 ? 322 LYS A CA 1 ATOM 2241 C C . LYS A 1 294 ? 41.866 -54.288 16.311 1.00 21.55 ? 322 LYS A C 1 ATOM 2242 O O . LYS A 1 294 ? 43.008 -54.537 16.687 1.00 20.73 ? 322 LYS A O 1 ATOM 2243 C CB . LYS A 1 294 ? 41.500 -54.471 13.813 1.00 21.62 ? 322 LYS A CB 1 ATOM 2244 C CG . LYS A 1 294 ? 41.197 -55.384 12.615 1.00 21.90 ? 322 LYS A CG 1 ATOM 2245 C CD . LYS A 1 294 ? 42.167 -56.541 12.511 1.00 20.25 ? 322 LYS A CD 1 ATOM 2246 C CE . LYS A 1 294 ? 42.024 -57.244 11.182 1.00 21.05 ? 322 LYS A CE 1 ATOM 2247 N NZ . LYS A 1 294 ? 42.887 -58.491 11.093 1.00 22.28 ? 322 LYS A NZ 1 ATOM 2248 N N . GLY A 1 295 ? 41.131 -53.308 16.827 1.00 21.59 ? 323 GLY A N 1 ATOM 2249 C CA . GLY A 1 295 ? 41.536 -52.574 18.027 1.00 22.19 ? 323 GLY A CA 1 ATOM 2250 C C . GLY A 1 295 ? 42.633 -51.528 17.893 1.00 22.37 ? 323 GLY A C 1 ATOM 2251 O O . GLY A 1 295 ? 42.887 -50.779 18.841 1.00 22.65 ? 323 GLY A O 1 ATOM 2252 N N . ASP A 1 296 ? 43.290 -51.493 16.730 1.00 22.17 ? 324 ASP A N 1 ATOM 2253 C CA . ASP A 1 296 ? 44.344 -50.514 16.422 1.00 22.03 ? 324 ASP A CA 1 ATOM 2254 C C . ASP A 1 296 ? 44.019 -49.781 15.106 1.00 21.40 ? 324 ASP A C 1 ATOM 2255 O O . ASP A 1 296 ? 44.875 -49.200 14.453 1.00 20.81 ? 324 ASP A O 1 ATOM 2256 C CB . ASP A 1 296 ? 45.749 -51.171 16.403 1.00 22.04 ? 324 ASP A CB 1 ATOM 2257 C CG . ASP A 1 296 ? 45.958 -52.139 15.220 1.00 23.34 ? 324 ASP A CG 1 ATOM 2258 O OD1 . ASP A 1 296 ? 44.968 -52.678 14.670 1.00 21.40 ? 324 ASP A OD1 1 ATOM 2259 O OD2 . ASP A 1 296 ? 47.136 -52.378 14.850 1.00 25.07 ? 324 ASP A OD2 1 ATOM 2260 N N . VAL A 1 297 ? 42.745 -49.836 14.751 1.00 21.48 ? 325 VAL A N 1 ATOM 2261 C CA . VAL A 1 297 ? 42.215 -49.217 13.556 1.00 21.46 ? 325 VAL A CA 1 ATOM 2262 C C . VAL A 1 297 ? 41.482 -47.954 13.957 1.00 21.27 ? 325 VAL A C 1 ATOM 2263 O O . VAL A 1 297 ? 40.749 -47.940 14.944 1.00 21.72 ? 325 VAL A O 1 ATOM 2264 C CB . VAL A 1 297 ? 41.288 -50.188 12.803 1.00 20.84 ? 325 VAL A CB 1 ATOM 2265 C CG1 . VAL A 1 297 ? 40.547 -49.485 11.696 1.00 21.47 ? 325 VAL A CG1 1 ATOM 2266 C CG2 . VAL A 1 297 ? 42.113 -51.314 12.223 1.00 21.58 ? 325 VAL A CG2 1 ATOM 2267 N N . LYS A 1 298 ? 41.687 -46.899 13.179 1.00 21.45 ? 326 LYS A N 1 ATOM 2268 C CA . LYS A 1 298 ? 41.104 -45.586 13.453 1.00 21.82 ? 326 LYS A CA 1 ATOM 2269 C C . LYS A 1 298 ? 39.627 -45.609 13.094 1.00 21.58 ? 326 LYS A C 1 ATOM 2270 O O . LYS A 1 298 ? 39.143 -46.589 12.500 1.00 21.13 ? 326 LYS A O 1 ATOM 2271 C CB . LYS A 1 298 ? 41.842 -44.515 12.652 1.00 22.17 ? 326 LYS A CB 1 ATOM 2272 C CG . LYS A 1 298 ? 43.312 -44.288 13.068 1.00 24.15 ? 326 LYS A CG 1 ATOM 2273 C CD . LYS A 1 298 ? 43.504 -42.956 13.785 1.00 31.09 ? 326 LYS A CD 1 ATOM 2274 C CE . LYS A 1 298 ? 43.266 -41.781 12.818 1.00 34.57 ? 326 LYS A CE 1 ATOM 2275 N NZ . LYS A 1 298 ? 43.170 -40.446 13.503 1.00 35.73 ? 326 LYS A NZ 1 ATOM 2276 N N . PRO A 1 299 ? 38.887 -44.554 13.480 1.00 21.55 ? 327 PRO A N 1 ATOM 2277 C CA . PRO A 1 299 ? 37.444 -44.535 13.179 1.00 21.20 ? 327 PRO A CA 1 ATOM 2278 C C . PRO A 1 299 ? 37.125 -44.619 11.672 1.00 21.56 ? 327 PRO A C 1 ATOM 2279 O O . PRO A 1 299 ? 37.770 -43.946 10.856 1.00 21.77 ? 327 PRO A O 1 ATOM 2280 C CB . PRO A 1 299 ? 36.987 -43.200 13.774 1.00 20.72 ? 327 PRO A CB 1 ATOM 2281 C CG . PRO A 1 299 ? 37.928 -42.955 14.886 1.00 20.45 ? 327 PRO A CG 1 ATOM 2282 C CD . PRO A 1 299 ? 39.262 -43.510 14.456 1.00 21.17 ? 327 PRO A CD 1 ATOM 2283 N N . LEU A 1 300 ? 36.144 -45.459 11.325 1.00 21.73 ? 328 LEU A N 1 ATOM 2284 C CA . LEU A 1 300 ? 35.663 -45.631 9.951 1.00 21.24 ? 328 LEU A CA 1 ATOM 2285 C C . LEU A 1 300 ? 35.147 -44.309 9.378 1.00 21.61 ? 328 LEU A C 1 ATOM 2286 O O . LEU A 1 300 ? 34.456 -43.542 10.060 1.00 22.33 ? 328 LEU A O 1 ATOM 2287 C CB . LEU A 1 300 ? 34.551 -46.666 9.934 1.00 20.57 ? 328 LEU A CB 1 ATOM 2288 C CG . LEU A 1 300 ? 33.911 -47.030 8.604 1.00 19.52 ? 328 LEU A CG 1 ATOM 2289 C CD1 . LEU A 1 300 ? 34.914 -47.714 7.686 1.00 18.87 ? 328 LEU A CD1 1 ATOM 2290 C CD2 . LEU A 1 300 ? 32.751 -47.938 8.862 1.00 17.62 ? 328 LEU A CD2 1 ATOM 2291 N N . ILE A 1 301 ? 35.508 -44.034 8.136 1.00 21.50 ? 329 ILE A N 1 ATOM 2292 C CA . ILE A 1 301 ? 35.085 -42.814 7.468 1.00 21.06 ? 329 ILE A CA 1 ATOM 2293 C C . ILE A 1 301 ? 34.061 -43.201 6.404 1.00 21.37 ? 329 ILE A C 1 ATOM 2294 O O . ILE A 1 301 ? 34.141 -44.298 5.799 1.00 20.63 ? 329 ILE A O 1 ATOM 2295 C CB . ILE A 1 301 ? 36.277 -42.075 6.821 1.00 20.66 ? 329 ILE A CB 1 ATOM 2296 C CG1 . ILE A 1 301 ? 37.239 -41.568 7.885 1.00 20.43 ? 329 ILE A CG1 1 ATOM 2297 C CG2 . ILE A 1 301 ? 35.794 -40.897 6.059 1.00 20.89 ? 329 ILE A CG2 1 ATOM 2298 C CD1 . ILE A 1 301 ? 38.686 -41.917 7.625 1.00 18.43 ? 329 ILE A CD1 1 ATOM 2299 N N . THR A 1 302 ? 33.096 -42.305 6.186 1.00 21.39 ? 330 THR A N 1 ATOM 2300 C CA . THR A 1 302 ? 32.098 -42.488 5.135 1.00 22.02 ? 330 THR A CA 1 ATOM 2301 C C . THR A 1 302 ? 31.612 -41.166 4.517 1.00 22.53 ? 330 THR A C 1 ATOM 2302 O O . THR A 1 302 ? 31.816 -40.083 5.093 1.00 22.72 ? 330 THR A O 1 ATOM 2303 C CB . THR A 1 302 ? 30.887 -43.292 5.658 1.00 22.22 ? 330 THR A CB 1 ATOM 2304 O OG1 . THR A 1 302 ? 30.103 -43.736 4.546 1.00 22.56 ? 330 THR A OG1 1 ATOM 2305 C CG2 . THR A 1 302 ? 30.013 -42.449 6.617 1.00 21.28 ? 330 THR A CG2 1 ATOM 2306 N N . VAL A 1 303 ? 30.996 -41.273 3.337 1.00 22.63 ? 331 VAL A N 1 ATOM 2307 C CA . VAL A 1 303 ? 30.161 -40.211 2.730 1.00 23.50 ? 331 VAL A CA 1 ATOM 2308 C C . VAL A 1 303 ? 28.815 -40.817 2.326 1.00 23.41 ? 331 VAL A C 1 ATOM 2309 O O . VAL A 1 303 ? 28.762 -41.844 1.614 1.00 23.14 ? 331 VAL A O 1 ATOM 2310 C CB . VAL A 1 303 ? 30.755 -39.528 1.457 1.00 23.12 ? 331 VAL A CB 1 ATOM 2311 C CG1 . VAL A 1 303 ? 31.921 -38.698 1.811 1.00 26.89 ? 331 VAL A CG1 1 ATOM 2312 C CG2 . VAL A 1 303 ? 31.122 -40.539 0.391 1.00 24.54 ? 331 VAL A CG2 1 ATOM 2313 N N . PRO A 1 304 ? 27.716 -40.187 2.766 1.00 23.53 ? 332 PRO A N 1 ATOM 2314 C CA . PRO A 1 304 ? 26.381 -40.687 2.412 1.00 23.81 ? 332 PRO A CA 1 ATOM 2315 C C . PRO A 1 304 ? 26.030 -40.338 0.977 1.00 24.17 ? 332 PRO A C 1 ATOM 2316 O O . PRO A 1 304 ? 26.631 -39.427 0.397 1.00 24.04 ? 332 PRO A O 1 ATOM 2317 C CB . PRO A 1 304 ? 25.446 -39.929 3.371 1.00 23.85 ? 332 PRO A CB 1 ATOM 2318 C CG . PRO A 1 304 ? 26.364 -39.147 4.320 1.00 23.91 ? 332 PRO A CG 1 ATOM 2319 C CD . PRO A 1 304 ? 27.650 -38.958 3.574 1.00 23.32 ? 332 PRO A CD 1 ATOM 2320 N N . THR A 1 305 ? 25.064 -41.058 0.409 1.00 24.75 ? 333 THR A N 1 ATOM 2321 C CA . THR A 1 305 ? 24.588 -40.763 -0.941 1.00 24.91 ? 333 THR A CA 1 ATOM 2322 C C . THR A 1 305 ? 24.029 -39.343 -1.062 1.00 25.33 ? 333 THR A C 1 ATOM 2323 O O . THR A 1 305 ? 24.078 -38.760 -2.145 1.00 26.17 ? 333 THR A O 1 ATOM 2324 C CB . THR A 1 305 ? 23.544 -41.756 -1.420 1.00 24.78 ? 333 THR A CB 1 ATOM 2325 O OG1 . THR A 1 305 ? 24.022 -43.080 -1.188 1.00 25.07 ? 333 THR A OG1 1 ATOM 2326 C CG2 . THR A 1 305 ? 23.299 -41.591 -2.910 1.00 23.92 ? 333 THR A CG2 1 ATOM 2327 N N . GLU A 1 306 ? 23.506 -38.787 0.028 1.00 25.14 ? 334 GLU A N 1 ATOM 2328 C CA . GLU A 1 306 ? 23.211 -37.346 0.086 1.00 25.22 ? 334 GLU A CA 1 ATOM 2329 C C . GLU A 1 306 ? 24.297 -36.656 0.920 1.00 24.85 ? 334 GLU A C 1 ATOM 2330 O O . GLU A 1 306 ? 24.428 -36.936 2.124 1.00 24.76 ? 334 GLU A O 1 ATOM 2331 C CB . GLU A 1 306 ? 21.825 -37.083 0.687 1.00 25.26 ? 334 GLU A CB 1 ATOM 2332 C CG . GLU A 1 306 ? 20.664 -37.686 -0.097 1.00 27.73 ? 334 GLU A CG 1 ATOM 2333 C CD . GLU A 1 306 ? 19.292 -37.483 0.584 1.00 32.01 ? 334 GLU A CD 1 ATOM 2334 O OE1 . GLU A 1 306 ? 19.274 -37.135 1.802 1.00 30.58 ? 334 GLU A OE1 1 ATOM 2335 O OE2 . GLU A 1 306 ? 18.244 -37.670 -0.113 1.00 31.30 ? 334 GLU A OE2 1 ATOM 2336 N N . TYR A 1 307 ? 25.070 -35.767 0.288 1.00 24.25 ? 335 TYR A N 1 ATOM 2337 C CA . TYR A 1 307 ? 26.330 -35.301 0.883 1.00 23.68 ? 335 TYR A CA 1 ATOM 2338 C C . TYR A 1 307 ? 26.599 -33.802 0.792 1.00 24.62 ? 335 TYR A C 1 ATOM 2339 O O . TYR A 1 307 ? 27.664 -33.330 1.190 1.00 24.45 ? 335 TYR A O 1 ATOM 2340 C CB . TYR A 1 307 ? 27.519 -36.109 0.340 1.00 22.77 ? 335 TYR A CB 1 ATOM 2341 C CG . TYR A 1 307 ? 27.702 -36.020 -1.158 1.00 20.75 ? 335 TYR A CG 1 ATOM 2342 C CD1 . TYR A 1 307 ? 28.294 -34.897 -1.745 1.00 16.72 ? 335 TYR A CD1 1 ATOM 2343 C CD2 . TYR A 1 307 ? 27.276 -37.053 -1.992 1.00 19.33 ? 335 TYR A CD2 1 ATOM 2344 C CE1 . TYR A 1 307 ? 28.445 -34.792 -3.106 1.00 14.13 ? 335 TYR A CE1 1 ATOM 2345 C CE2 . TYR A 1 307 ? 27.431 -36.961 -3.368 1.00 18.38 ? 335 TYR A CE2 1 ATOM 2346 C CZ . TYR A 1 307 ? 28.025 -35.819 -3.909 1.00 16.49 ? 335 TYR A CZ 1 ATOM 2347 O OH . TYR A 1 307 ? 28.190 -35.732 -5.262 1.00 15.49 ? 335 TYR A OH 1 ATOM 2348 N N . ASP A 1 308 ? 25.632 -33.046 0.286 1.00 25.73 ? 336 ASP A N 1 ATOM 2349 C CA . ASP A 1 308 ? 25.689 -31.596 0.395 1.00 26.98 ? 336 ASP A CA 1 ATOM 2350 C C . ASP A 1 308 ? 24.379 -31.093 0.963 1.00 27.52 ? 336 ASP A C 1 ATOM 2351 O O . ASP A 1 308 ? 23.345 -31.700 0.740 1.00 27.62 ? 336 ASP A O 1 ATOM 2352 C CB . ASP A 1 308 ? 25.998 -30.938 -0.959 1.00 27.53 ? 336 ASP A CB 1 ATOM 2353 C CG . ASP A 1 308 ? 24.843 -31.054 -1.969 1.00 29.30 ? 336 ASP A CG 1 ATOM 2354 O OD1 . ASP A 1 308 ? 24.744 -32.108 -2.644 1.00 30.54 ? 336 ASP A OD1 1 ATOM 2355 O OD2 . ASP A 1 308 ? 24.035 -30.093 -2.076 1.00 30.40 ? 336 ASP A OD2 1 ATOM 2356 N N . THR A 1 309 ? 24.415 -29.976 1.682 1.00 28.61 ? 337 THR A N 1 ATOM 2357 C CA . THR A 1 309 ? 23.233 -29.486 2.392 1.00 29.53 ? 337 THR A CA 1 ATOM 2358 C C . THR A 1 309 ? 21.988 -29.450 1.519 1.00 30.20 ? 337 THR A C 1 ATOM 2359 O O . THR A 1 309 ? 20.919 -29.864 1.953 1.00 30.83 ? 337 THR A O 1 ATOM 2360 C CB . THR A 1 309 ? 23.476 -28.104 2.981 1.00 29.86 ? 337 THR A CB 1 ATOM 2361 O OG1 . THR A 1 309 ? 24.626 -28.166 3.830 1.00 30.37 ? 337 THR A OG1 1 ATOM 2362 C CG2 . THR A 1 309 ? 22.259 -27.637 3.788 1.00 28.86 ? 337 THR A CG2 1 ATOM 2363 N N . GLY A 1 310 ? 22.142 -28.965 0.286 1.00 30.82 ? 338 GLY A N 1 ATOM 2364 C CA . GLY A 1 310 ? 21.067 -28.931 -0.702 1.00 30.61 ? 338 GLY A CA 1 ATOM 2365 C C . GLY A 1 310 ? 20.385 -30.268 -0.891 1.00 30.74 ? 338 GLY A C 1 ATOM 2366 O O . GLY A 1 310 ? 19.164 -30.326 -0.925 1.00 31.53 ? 338 GLY A O 1 ATOM 2367 N N . ALA A 1 311 ? 21.162 -31.338 -1.014 1.00 30.64 ? 339 ALA A N 1 ATOM 2368 C CA . ALA A 1 311 ? 20.618 -32.684 -1.206 1.00 30.84 ? 339 ALA A CA 1 ATOM 2369 C C . ALA A 1 311 ? 20.215 -33.377 0.118 1.00 31.24 ? 339 ALA A C 1 ATOM 2370 O O . ALA A 1 311 ? 19.546 -34.430 0.117 1.00 30.75 ? 339 ALA A O 1 ATOM 2371 C CB . ALA A 1 311 ? 21.619 -33.543 -1.976 1.00 30.78 ? 339 ALA A CB 1 ATOM 2372 N N . MET A 1 312 ? 20.612 -32.778 1.240 1.00 31.52 ? 340 MET A N 1 ATOM 2373 C CA . MET A 1 312 ? 20.451 -33.414 2.551 1.00 32.32 ? 340 MET A CA 1 ATOM 2374 C C . MET A 1 312 ? 19.278 -32.812 3.305 1.00 32.93 ? 340 MET A C 1 ATOM 2375 O O . MET A 1 312 ? 18.660 -33.463 4.139 1.00 32.43 ? 340 MET A O 1 ATOM 2376 C CB . MET A 1 312 ? 21.728 -33.266 3.407 1.00 31.81 ? 340 MET A CB 1 ATOM 2377 C CG . MET A 1 312 ? 22.945 -34.045 2.937 1.00 31.44 ? 340 MET A CG 1 ATOM 2378 S SD . MET A 1 312 ? 24.510 -33.417 3.625 1.00 31.64 ? 340 MET A SD 1 ATOM 2379 C CE . MET A 1 312 ? 24.482 -34.142 5.267 1.00 29.56 ? 340 MET A CE 1 ATOM 2380 N N . VAL A 1 313 ? 18.993 -31.553 3.012 1.00 34.16 ? 341 VAL A N 1 ATOM 2381 C CA . VAL A 1 313 ? 18.084 -30.775 3.826 1.00 35.72 ? 341 VAL A CA 1 ATOM 2382 C C . VAL A 1 313 ? 17.084 -30.017 2.971 1.00 37.05 ? 341 VAL A C 1 ATOM 2383 O O . VAL A 1 313 ? 17.425 -29.497 1.903 1.00 37.64 ? 341 VAL A O 1 ATOM 2384 C CB . VAL A 1 313 ? 18.879 -29.837 4.755 1.00 35.71 ? 341 VAL A CB 1 ATOM 2385 C CG1 . VAL A 1 313 ? 18.022 -28.658 5.270 1.00 36.25 ? 341 VAL A CG1 1 ATOM 2386 C CG2 . VAL A 1 313 ? 19.466 -30.638 5.893 1.00 34.77 ? 341 VAL A CG2 1 ATOM 2387 N N . SER A 1 314 ? 15.845 -29.982 3.457 1.00 38.90 ? 342 SER A N 1 ATOM 2388 C CA . SER A 1 314 ? 14.697 -29.365 2.771 1.00 40.51 ? 342 SER A CA 1 ATOM 2389 C C . SER A 1 314 ? 13.885 -28.579 3.804 1.00 41.24 ? 342 SER A C 1 ATOM 2390 O O . SER A 1 314 ? 13.362 -29.168 4.773 1.00 41.88 ? 342 SER A O 1 ATOM 2391 C CB . SER A 1 314 ? 13.833 -30.460 2.133 1.00 40.66 ? 342 SER A CB 1 ATOM 2392 O OG . SER A 1 314 ? 12.715 -29.927 1.453 1.00 42.21 ? 342 SER A OG 1 ATOM 2393 N N . ASN A 1 315 ? 13.804 -27.258 3.615 1.00 41.74 ? 343 ASN A N 1 ATOM 2394 C CA . ASN A 1 315 ? 13.124 -26.359 4.568 1.00 42.05 ? 343 ASN A CA 1 ATOM 2395 C C . ASN A 1 315 ? 13.559 -26.573 6.040 1.00 42.13 ? 343 ASN A C 1 ATOM 2396 O O . ASN A 1 315 ? 12.705 -26.672 6.931 1.00 42.45 ? 343 ASN A O 1 ATOM 2397 C CB . ASN A 1 315 ? 11.579 -26.436 4.416 1.00 42.05 ? 343 ASN A CB 1 ATOM 2398 C CG . ASN A 1 315 ? 11.097 -25.987 3.048 0.010 41.87 ? 343 ASN A CG 1 ATOM 2399 O OD1 . ASN A 1 315 ? 11.548 -24.972 2.516 0.010 41.77 ? 343 ASN A OD1 1 ATOM 2400 N ND2 . ASN A 1 315 ? 10.164 -26.739 2.477 0.010 41.77 ? 343 ASN A ND2 1 ATOM 2401 N N . GLY A 1 316 ? 14.877 -26.657 6.275 1.00 42.06 ? 344 GLY A N 1 ATOM 2402 C CA . GLY A 1 316 ? 15.466 -26.694 7.638 1.00 41.14 ? 344 GLY A CA 1 ATOM 2403 C C . GLY A 1 316 ? 15.502 -28.072 8.299 1.00 40.86 ? 344 GLY A C 1 ATOM 2404 O O . GLY A 1 316 ? 16.151 -28.260 9.340 1.00 40.64 ? 344 GLY A O 1 ATOM 2405 N N . GLN A 1 317 ? 14.812 -29.031 7.676 1.00 40.24 ? 345 GLN A N 1 ATOM 2406 C CA . GLN A 1 317 ? 14.629 -30.385 8.197 1.00 39.78 ? 345 GLN A CA 1 ATOM 2407 C C . GLN A 1 317 ? 15.238 -31.414 7.235 1.00 39.10 ? 345 GLN A C 1 ATOM 2408 O O . GLN A 1 317 ? 15.115 -31.263 6.014 1.00 39.27 ? 345 GLN A O 1 ATOM 2409 C CB . GLN A 1 317 ? 13.121 -30.674 8.374 1.00 40.34 ? 345 GLN A CB 1 ATOM 2410 C CG . GLN A 1 317 ? 12.471 -30.007 9.598 1.00 41.39 ? 345 GLN A CG 1 ATOM 2411 C CD . GLN A 1 317 ? 13.119 -30.453 10.909 1.00 44.87 ? 345 GLN A CD 1 ATOM 2412 O OE1 . GLN A 1 317 ? 13.778 -29.663 11.591 1.00 46.50 ? 345 GLN A OE1 1 ATOM 2413 N NE2 . GLN A 1 317 ? 12.957 -31.733 11.249 1.00 45.65 ? 345 GLN A NE2 1 ATOM 2414 N N . PRO A 1 318 ? 15.882 -32.474 7.770 1.00 38.32 ? 346 PRO A N 1 ATOM 2415 C CA . PRO A 1 318 ? 16.561 -33.427 6.878 1.00 37.51 ? 346 PRO A CA 1 ATOM 2416 C C . PRO A 1 318 ? 15.600 -34.173 5.978 1.00 36.81 ? 346 PRO A C 1 ATOM 2417 O O . PRO A 1 318 ? 14.472 -34.414 6.375 1.00 37.13 ? 346 PRO A O 1 ATOM 2418 C CB . PRO A 1 318 ? 17.242 -34.405 7.848 1.00 37.49 ? 346 PRO A CB 1 ATOM 2419 C CG . PRO A 1 318 ? 16.516 -34.242 9.147 1.00 37.73 ? 346 PRO A CG 1 ATOM 2420 C CD . PRO A 1 318 ? 16.075 -32.816 9.194 1.00 38.33 ? 346 PRO A CD 1 ATOM 2421 N N . ARG A 1 319 ? 16.051 -34.524 4.776 1.00 36.30 ? 347 ARG A N 1 ATOM 2422 C CA . ARG A 1 319 ? 15.287 -35.385 3.874 1.00 35.92 ? 347 ARG A CA 1 ATOM 2423 C C . ARG A 1 319 ? 15.278 -36.812 4.390 1.00 35.37 ? 347 ARG A C 1 ATOM 2424 O O . ARG A 1 319 ? 16.006 -37.150 5.329 1.00 35.23 ? 347 ARG A O 1 ATOM 2425 C CB . ARG A 1 319 ? 15.857 -35.373 2.452 1.00 36.22 ? 347 ARG A CB 1 ATOM 2426 C CG . ARG A 1 319 ? 15.725 -34.059 1.712 1.00 37.90 ? 347 ARG A CG 1 ATOM 2427 C CD . ARG A 1 319 ? 15.846 -34.289 0.208 1.00 42.50 ? 347 ARG A CD 1 ATOM 2428 N NE . ARG A 1 319 ? 16.432 -33.134 -0.480 1.00 46.00 ? 347 ARG A NE 1 ATOM 2429 C CZ . ARG A 1 319 ? 15.745 -32.089 -0.946 1.00 47.46 ? 347 ARG A CZ 1 ATOM 2430 N NH1 . ARG A 1 319 ? 14.424 -32.019 -0.804 1.00 47.28 ? 347 ARG A NH1 1 ATOM 2431 N NH2 . ARG A 1 319 ? 16.387 -31.099 -1.547 1.00 48.49 ? 347 ARG A NH2 1 ATOM 2432 N N . ALA A 1 320 ? 14.460 -37.646 3.750 1.00 34.85 ? 348 ALA A N 1 ATOM 2433 C CA . ALA A 1 320 ? 14.240 -39.023 4.178 1.00 33.86 ? 348 ALA A CA 1 ATOM 2434 C C . ALA A 1 320 ? 15.556 -39.780 4.331 1.00 33.31 ? 348 ALA A C 1 ATOM 2435 O O . ALA A 1 320 ? 15.845 -40.323 5.409 1.00 33.43 ? 348 ALA A O 1 ATOM 2436 C CB . ALA A 1 320 ? 13.307 -39.745 3.193 1.00 33.85 ? 348 ALA A CB 1 ATOM 2437 N N . TYR A 1 321 ? 16.348 -39.807 3.258 1.00 32.21 ? 349 TYR A N 1 ATOM 2438 C CA . TYR A 1 321 ? 17.604 -40.550 3.256 1.00 31.16 ? 349 TYR A CA 1 ATOM 2439 C C . TYR A 1 321 ? 18.520 -40.077 4.399 1.00 30.93 ? 349 TYR A C 1 ATOM 2440 O O . TYR A 1 321 ? 18.949 -40.866 5.233 1.00 31.07 ? 349 TYR A O 1 ATOM 2441 C CB . TYR A 1 321 ? 18.305 -40.448 1.896 1.00 30.56 ? 349 TYR A CB 1 ATOM 2442 C CG . TYR A 1 321 ? 19.655 -41.123 1.871 1.00 29.80 ? 349 TYR A CG 1 ATOM 2443 C CD1 . TYR A 1 321 ? 20.791 -40.484 2.386 1.00 27.38 ? 349 TYR A CD1 1 ATOM 2444 C CD2 . TYR A 1 321 ? 19.804 -42.412 1.343 1.00 28.78 ? 349 TYR A CD2 1 ATOM 2445 C CE1 . TYR A 1 321 ? 22.027 -41.113 2.384 1.00 27.93 ? 349 TYR A CE1 1 ATOM 2446 C CE2 . TYR A 1 321 ? 21.052 -43.049 1.331 1.00 27.39 ? 349 TYR A CE2 1 ATOM 2447 C CZ . TYR A 1 321 ? 22.154 -42.394 1.855 1.00 27.42 ? 349 TYR A CZ 1 ATOM 2448 O OH . TYR A 1 321 ? 23.386 -43.004 1.844 1.00 26.72 ? 349 TYR A OH 1 ATOM 2449 N N . THR A 1 322 ? 18.808 -38.788 4.433 1.00 30.69 ? 350 THR A N 1 ATOM 2450 C CA . THR A 1 322 ? 19.645 -38.227 5.473 1.00 31.07 ? 350 THR A CA 1 ATOM 2451 C C . THR A 1 322 ? 19.113 -38.532 6.876 1.00 31.79 ? 350 THR A C 1 ATOM 2452 O O . THR A 1 322 ? 19.878 -38.989 7.723 1.00 32.48 ? 350 THR A O 1 ATOM 2453 C CB . THR A 1 322 ? 19.815 -36.725 5.281 1.00 30.73 ? 350 THR A CB 1 ATOM 2454 O OG1 . THR A 1 322 ? 20.455 -36.496 4.024 1.00 31.20 ? 350 THR A OG1 1 ATOM 2455 C CG2 . THR A 1 322 ? 20.646 -36.119 6.385 1.00 30.03 ? 350 THR A CG2 1 ATOM 2456 N N . ARG A 1 323 ? 17.819 -38.299 7.132 1.00 32.24 ? 351 ARG A N 1 ATOM 2457 C CA . ARG A 1 323 ? 17.261 -38.538 8.477 1.00 31.80 ? 351 ARG A CA 1 ATOM 2458 C C . ARG A 1 323 ? 17.450 -39.995 8.890 1.00 30.96 ? 351 ARG A C 1 ATOM 2459 O O . ARG A 1 323 ? 17.872 -40.266 10.025 1.00 30.96 ? 351 ARG A O 1 ATOM 2460 C CB . ARG A 1 323 ? 15.786 -38.125 8.575 1.00 32.20 ? 351 ARG A CB 1 ATOM 2461 C CG . ARG A 1 323 ? 15.109 -38.388 9.961 1.00 34.34 ? 351 ARG A CG 1 ATOM 2462 C CD . ARG A 1 323 ? 13.612 -38.021 9.982 1.00 37.26 ? 351 ARG A CD 1 ATOM 2463 N NE . ARG A 1 323 ? 12.932 -38.493 8.763 1.00 40.67 ? 351 ARG A NE 1 ATOM 2464 C CZ . ARG A 1 323 ? 12.540 -39.752 8.529 1.00 41.72 ? 351 ARG A CZ 1 ATOM 2465 N NH1 . ARG A 1 323 ? 12.737 -40.722 9.435 1.00 41.48 ? 351 ARG A NH1 1 ATOM 2466 N NH2 . ARG A 1 323 ? 11.952 -40.043 7.372 1.00 40.49 ? 351 ARG A NH2 1 ATOM 2467 N N . ILE A 1 324 ? 17.162 -40.923 7.979 1.00 29.62 ? 352 ILE A N 1 ATOM 2468 C CA . ILE A 1 324 ? 17.300 -42.333 8.314 1.00 29.20 ? 352 ILE A CA 1 ATOM 2469 C C . ILE A 1 324 ? 18.769 -42.670 8.529 1.00 29.33 ? 352 ILE A C 1 ATOM 2470 O O . ILE A 1 324 ? 19.127 -43.285 9.542 1.00 29.18 ? 352 ILE A O 1 ATOM 2471 C CB . ILE A 1 324 ? 16.660 -43.282 7.270 1.00 28.88 ? 352 ILE A CB 1 ATOM 2472 C CG1 . ILE A 1 324 ? 15.129 -43.097 7.243 1.00 29.53 ? 352 ILE A CG1 1 ATOM 2473 C CG2 . ILE A 1 324 ? 17.016 -44.740 7.581 1.00 28.33 ? 352 ILE A CG2 1 ATOM 2474 C CD1 . ILE A 1 324 ? 14.370 -43.949 6.172 1.00 28.48 ? 352 ILE A CD1 1 ATOM 2475 N N . PHE A 1 325 ? 19.622 -42.254 7.586 1.00 29.56 ? 353 PHE A N 1 ATOM 2476 C CA . PHE A 1 325 ? 21.072 -42.498 7.684 1.00 29.50 ? 353 PHE A CA 1 ATOM 2477 C C . PHE A 1 325 ? 21.683 -41.953 9.000 1.00 29.89 ? 353 PHE A C 1 ATOM 2478 O O . PHE A 1 325 ? 22.437 -42.658 9.656 1.00 29.63 ? 353 PHE A O 1 ATOM 2479 C CB . PHE A 1 325 ? 21.800 -41.940 6.454 1.00 29.43 ? 353 PHE A CB 1 ATOM 2480 C CG . PHE A 1 325 ? 23.232 -42.405 6.312 1.00 27.93 ? 353 PHE A CG 1 ATOM 2481 C CD1 . PHE A 1 325 ? 24.269 -41.741 6.970 1.00 26.81 ? 353 PHE A CD1 1 ATOM 2482 C CD2 . PHE A 1 325 ? 23.546 -43.486 5.497 1.00 26.69 ? 353 PHE A CD2 1 ATOM 2483 C CE1 . PHE A 1 325 ? 25.575 -42.163 6.836 1.00 25.72 ? 353 PHE A CE1 1 ATOM 2484 C CE2 . PHE A 1 325 ? 24.865 -43.912 5.357 1.00 24.99 ? 353 PHE A CE2 1 ATOM 2485 C CZ . PHE A 1 325 ? 25.869 -43.244 6.015 1.00 26.21 ? 353 PHE A CZ 1 ATOM 2486 N N . ALA A 1 326 ? 21.351 -40.720 9.379 1.00 30.46 ? 354 ALA A N 1 ATOM 2487 C CA . ALA A 1 326 ? 21.823 -40.149 10.644 1.00 31.95 ? 354 ALA A CA 1 ATOM 2488 C C . ALA A 1 326 ? 21.336 -40.940 11.874 1.00 33.11 ? 354 ALA A C 1 ATOM 2489 O O . ALA A 1 326 ? 22.080 -41.131 12.838 1.00 33.22 ? 354 ALA A O 1 ATOM 2490 C CB . ALA A 1 326 ? 21.409 -38.688 10.756 1.00 31.64 ? 354 ALA A CB 1 ATOM 2491 N N . GLU A 1 327 ? 20.084 -41.385 11.822 1.00 34.15 ? 355 GLU A N 1 ATOM 2492 C CA . GLU A 1 327 ? 19.444 -42.147 12.887 1.00 35.28 ? 355 GLU A CA 1 ATOM 2493 C C . GLU A 1 327 ? 20.200 -43.481 13.103 1.00 34.52 ? 355 GLU A C 1 ATOM 2494 O O . GLU A 1 327 ? 20.397 -43.921 14.246 1.00 34.39 ? 355 GLU A O 1 ATOM 2495 C CB . GLU A 1 327 ? 18.001 -42.415 12.440 1.00 36.32 ? 355 GLU A CB 1 ATOM 2496 C CG . GLU A 1 327 ? 16.893 -42.637 13.475 1.00 41.54 ? 355 GLU A CG 1 ATOM 2497 C CD . GLU A 1 327 ? 15.475 -42.601 12.797 1.00 48.44 ? 355 GLU A CD 1 ATOM 2498 O OE1 . GLU A 1 327 ? 15.258 -43.323 11.775 1.00 49.32 ? 355 GLU A OE1 1 ATOM 2499 O OE2 . GLU A 1 327 ? 14.590 -41.832 13.272 1.00 49.73 ? 355 GLU A OE2 1 ATOM 2500 N N . THR A 1 328 ? 20.642 -44.100 12.006 1.00 33.25 ? 356 THR A N 1 ATOM 2501 C CA . THR A 1 328 ? 21.220 -45.446 12.072 1.00 32.67 ? 356 THR A CA 1 ATOM 2502 C C . THR A 1 328 ? 22.739 -45.455 12.239 1.00 32.16 ? 356 THR A C 1 ATOM 2503 O O . THR A 1 328 ? 23.263 -46.247 13.016 1.00 31.97 ? 356 THR A O 1 ATOM 2504 C CB . THR A 1 328 ? 20.863 -46.303 10.822 1.00 32.56 ? 356 THR A CB 1 ATOM 2505 O OG1 . THR A 1 328 ? 19.543 -45.982 10.378 1.00 33.30 ? 356 THR A OG1 1 ATOM 2506 C CG2 . THR A 1 328 ? 20.950 -47.788 11.123 1.00 31.29 ? 356 THR A CG2 1 ATOM 2507 N N . VAL A 1 329 ? 23.438 -44.596 11.501 1.00 31.70 ? 357 VAL A N 1 ATOM 2508 C CA . VAL A 1 329 ? 24.897 -44.646 11.471 1.00 31.59 ? 357 VAL A CA 1 ATOM 2509 C C . VAL A 1 329 ? 25.503 -44.476 12.866 1.00 31.42 ? 357 VAL A C 1 ATOM 2510 O O . VAL A 1 329 ? 25.190 -43.544 13.589 1.00 31.15 ? 357 VAL A O 1 ATOM 2511 C CB . VAL A 1 329 ? 25.519 -43.662 10.441 1.00 31.37 ? 357 VAL A CB 1 ATOM 2512 C CG1 . VAL A 1 329 ? 25.544 -42.231 10.980 1.00 31.76 ? 357 VAL A CG1 1 ATOM 2513 C CG2 . VAL A 1 329 ? 26.914 -44.118 10.059 1.00 30.83 ? 357 VAL A CG2 1 ATOM 2514 N N . ASP A 1 330 ? 26.352 -45.421 13.224 1.00 31.83 ? 358 ASP A N 1 ATOM 2515 C CA . ASP A 1 330 ? 27.090 -45.377 14.472 1.00 32.76 ? 358 ASP A CA 1 ATOM 2516 C C . ASP A 1 330 ? 27.816 -44.056 14.719 1.00 31.49 ? 358 ASP A C 1 ATOM 2517 O O . ASP A 1 330 ? 28.442 -43.508 13.826 1.00 31.13 ? 358 ASP A O 1 ATOM 2518 C CB . ASP A 1 330 ? 28.084 -46.540 14.559 1.00 33.84 ? 358 ASP A CB 1 ATOM 2519 C CG . ASP A 1 330 ? 28.632 -46.717 15.958 1.00 38.95 ? 358 ASP A CG 1 ATOM 2520 O OD1 . ASP A 1 330 ? 29.517 -45.919 16.414 1.00 43.58 ? 358 ASP A OD1 1 ATOM 2521 O OD2 . ASP A 1 330 ? 28.130 -47.656 16.622 1.00 43.84 ? 358 ASP A OD2 1 ATOM 2522 N N . PRO A 1 331 ? 27.709 -43.546 15.959 1.00 31.19 ? 359 PRO A N 1 ATOM 2523 C CA . PRO A 1 331 ? 28.314 -42.289 16.413 1.00 30.44 ? 359 PRO A CA 1 ATOM 2524 C C . PRO A 1 331 ? 29.828 -42.199 16.254 1.00 29.78 ? 359 PRO A C 1 ATOM 2525 O O . PRO A 1 331 ? 30.350 -41.098 16.126 1.00 29.71 ? 359 PRO A O 1 ATOM 2526 C CB . PRO A 1 331 ? 27.923 -42.222 17.906 1.00 30.46 ? 359 PRO A CB 1 ATOM 2527 C CG . PRO A 1 331 ? 26.632 -42.979 17.993 1.00 30.64 ? 359 PRO A CG 1 ATOM 2528 C CD . PRO A 1 331 ? 26.774 -44.102 16.971 1.00 31.27 ? 359 PRO A CD 1 ATOM 2529 N N . SER A 1 332 ? 30.528 -43.324 16.270 1.00 29.10 ? 360 SER A N 1 ATOM 2530 C CA . SER A 1 332 ? 31.986 -43.277 16.204 1.00 28.73 ? 360 SER A CA 1 ATOM 2531 C C . SER A 1 332 ? 32.500 -43.087 14.764 1.00 27.95 ? 360 SER A C 1 ATOM 2532 O O . SER A 1 332 ? 33.671 -42.730 14.550 1.00 28.14 ? 360 SER A O 1 ATOM 2533 C CB . SER A 1 332 ? 32.592 -44.528 16.839 1.00 28.90 ? 360 SER A CB 1 ATOM 2534 O OG . SER A 1 332 ? 32.224 -45.683 16.108 1.00 30.23 ? 360 SER A OG 1 ATOM 2535 N N . ILE A 1 333 ? 31.615 -43.309 13.798 1.00 26.33 ? 361 ILE A N 1 ATOM 2536 C CA . ILE A 1 333 ? 31.945 -43.209 12.374 1.00 25.72 ? 361 ILE A CA 1 ATOM 2537 C C . ILE A 1 333 ? 32.032 -41.759 11.888 1.00 25.52 ? 361 ILE A C 1 ATOM 2538 O O . ILE A 1 333 ? 31.111 -40.971 12.099 1.00 25.43 ? 361 ILE A O 1 ATOM 2539 C CB . ILE A 1 333 ? 30.930 -43.998 11.501 1.00 25.38 ? 361 ILE A CB 1 ATOM 2540 C CG1 . ILE A 1 333 ? 30.896 -45.469 11.918 1.00 25.21 ? 361 ILE A CG1 1 ATOM 2541 C CG2 . ILE A 1 333 ? 31.272 -43.893 10.040 1.00 24.50 ? 361 ILE A CG2 1 ATOM 2542 C CD1 . ILE A 1 333 ? 29.748 -46.252 11.311 1.00 26.31 ? 361 ILE A CD1 1 ATOM 2543 N N . GLU A 1 334 ? 33.138 -41.408 11.237 1.00 24.97 ? 362 GLU A N 1 ATOM 2544 C CA . GLU A 1 334 ? 33.235 -40.090 10.641 1.00 24.99 ? 362 GLU A CA 1 ATOM 2545 C C . GLU A 1 334 ? 32.318 -40.004 9.414 1.00 24.76 ? 362 GLU A C 1 ATOM 2546 O O . GLU A 1 334 ? 32.311 -40.917 8.578 1.00 24.76 ? 362 GLU A O 1 ATOM 2547 C CB . GLU A 1 334 ? 34.663 -39.762 10.247 1.00 25.20 ? 362 GLU A CB 1 ATOM 2548 C CG . GLU A 1 334 ? 35.687 -39.919 11.365 1.00 26.29 ? 362 GLU A CG 1 ATOM 2549 C CD . GLU A 1 334 ? 35.575 -38.864 12.465 1.00 27.19 ? 362 GLU A CD 1 ATOM 2550 O OE1 . GLU A 1 334 ? 35.055 -37.749 12.218 1.00 26.22 ? 362 GLU A OE1 1 ATOM 2551 O OE2 . GLU A 1 334 ? 36.027 -39.154 13.596 1.00 27.91 ? 362 GLU A OE2 1 ATOM 2552 N N . VAL A 1 335 ? 31.532 -38.925 9.332 1.00 23.63 ? 363 VAL A N 1 ATOM 2553 C CA . VAL A 1 335 ? 30.659 -38.693 8.203 1.00 23.14 ? 363 VAL A CA 1 ATOM 2554 C C . VAL A 1 335 ? 31.113 -37.408 7.542 1.00 23.25 ? 363 VAL A C 1 ATOM 2555 O O . VAL A 1 335 ? 31.331 -36.400 8.221 1.00 22.75 ? 363 VAL A O 1 ATOM 2556 C CB . VAL A 1 335 ? 29.184 -38.582 8.618 1.00 23.16 ? 363 VAL A CB 1 ATOM 2557 C CG1 . VAL A 1 335 ? 28.308 -38.445 7.410 1.00 23.16 ? 363 VAL A CG1 1 ATOM 2558 C CG2 . VAL A 1 335 ? 28.755 -39.819 9.401 1.00 23.58 ? 363 VAL A CG2 1 ATOM 2559 N N . MET A 1 336 ? 31.297 -37.467 6.221 1.00 22.97 ? 364 MET A N 1 ATOM 2560 C CA . MET A 1 336 ? 31.777 -36.321 5.453 1.00 22.75 ? 364 MET A CA 1 ATOM 2561 C C . MET A 1 336 ? 30.617 -35.668 4.708 1.00 22.65 ? 364 MET A C 1 ATOM 2562 O O . MET A 1 336 ? 29.621 -36.339 4.367 1.00 22.23 ? 364 MET A O 1 ATOM 2563 C CB . MET A 1 336 ? 32.845 -36.728 4.429 1.00 22.77 ? 364 MET A CB 1 ATOM 2564 C CG . MET A 1 336 ? 33.898 -37.704 4.930 1.00 23.48 ? 364 MET A CG 1 ATOM 2565 S SD . MET A 1 336 ? 35.162 -38.071 3.699 1.00 23.98 ? 364 MET A SD 1 ATOM 2566 C CE . MET A 1 336 ? 36.154 -36.581 3.739 1.00 21.18 ? 364 MET A CE 1 ATOM 2567 N N . TRP A 1 337 ? 30.768 -34.358 4.466 1.00 22.15 ? 365 TRP A N 1 ATOM 2568 C CA . TRP A 1 337 ? 29.853 -33.584 3.627 1.00 22.02 ? 365 TRP A CA 1 ATOM 2569 C C . TRP A 1 337 ? 30.618 -32.456 2.926 1.00 21.83 ? 365 TRP A C 1 ATOM 2570 O O . TRP A 1 337 ? 31.672 -32.040 3.408 1.00 22.26 ? 365 TRP A O 1 ATOM 2571 C CB . TRP A 1 337 ? 28.606 -33.130 4.420 1.00 21.66 ? 365 TRP A CB 1 ATOM 2572 C CG . TRP A 1 337 ? 28.469 -31.691 4.784 1.00 21.68 ? 365 TRP A CG 1 ATOM 2573 C CD1 . TRP A 1 337 ? 27.526 -30.817 4.305 1.00 21.62 ? 365 TRP A CD1 1 ATOM 2574 C CD2 . TRP A 1 337 ? 29.239 -30.956 5.740 1.00 20.59 ? 365 TRP A CD2 1 ATOM 2575 N NE1 . TRP A 1 337 ? 27.681 -29.581 4.884 1.00 19.54 ? 365 TRP A NE1 1 ATOM 2576 C CE2 . TRP A 1 337 ? 28.725 -29.640 5.768 1.00 20.62 ? 365 TRP A CE2 1 ATOM 2577 C CE3 . TRP A 1 337 ? 30.323 -31.274 6.563 1.00 23.31 ? 365 TRP A CE3 1 ATOM 2578 C CZ2 . TRP A 1 337 ? 29.262 -28.638 6.587 1.00 22.09 ? 365 TRP A CZ2 1 ATOM 2579 C CZ3 . TRP A 1 337 ? 30.867 -30.261 7.389 1.00 23.74 ? 365 TRP A CZ3 1 ATOM 2580 C CH2 . TRP A 1 337 ? 30.331 -28.964 7.384 1.00 22.48 ? 365 TRP A CH2 1 ATOM 2581 N N . THR A 1 338 ? 30.110 -31.995 1.786 1.00 21.17 ? 366 THR A N 1 ATOM 2582 C CA . THR A 1 338 ? 30.837 -31.042 0.966 1.00 21.46 ? 366 THR A CA 1 ATOM 2583 C C . THR A 1 338 ? 30.544 -29.579 1.289 1.00 21.28 ? 366 THR A C 1 ATOM 2584 O O . THR A 1 338 ? 31.147 -28.688 0.701 1.00 21.16 ? 366 THR A O 1 ATOM 2585 C CB . THR A 1 338 ? 30.614 -31.286 -0.543 1.00 21.56 ? 366 THR A CB 1 ATOM 2586 O OG1 . THR A 1 338 ? 29.255 -31.020 -0.875 1.00 22.78 ? 366 THR A OG1 1 ATOM 2587 C CG2 . THR A 1 338 ? 30.921 -32.722 -0.918 1.00 22.45 ? 366 THR A CG2 1 ATOM 2588 N N . GLY A 1 339 ? 29.657 -29.337 2.253 1.00 21.58 ? 367 GLY A N 1 ATOM 2589 C CA . GLY A 1 339 ? 29.157 -27.988 2.541 1.00 21.98 ? 367 GLY A CA 1 ATOM 2590 C C . GLY A 1 339 ? 27.785 -27.791 1.903 1.00 22.12 ? 367 GLY A C 1 ATOM 2591 O O . GLY A 1 339 ? 27.109 -28.784 1.600 1.00 22.11 ? 367 GLY A O 1 ATOM 2592 N N . PRO A 1 340 ? 27.373 -26.523 1.693 1.00 22.10 ? 368 PRO A N 1 ATOM 2593 C CA . PRO A 1 340 ? 26.042 -26.138 1.186 1.00 22.82 ? 368 PRO A CA 1 ATOM 2594 C C . PRO A 1 340 ? 25.706 -26.639 -0.218 1.00 23.26 ? 368 PRO A C 1 ATOM 2595 O O . PRO A 1 340 ? 24.520 -26.748 -0.567 1.00 24.22 ? 368 PRO A O 1 ATOM 2596 C CB . PRO A 1 340 ? 26.089 -24.601 1.180 1.00 22.73 ? 368 PRO A CB 1 ATOM 2597 C CG . PRO A 1 340 ? 27.097 -24.251 2.187 1.00 22.57 ? 368 PRO A CG 1 ATOM 2598 C CD . PRO A 1 340 ? 28.144 -25.342 2.124 1.00 22.18 ? 368 PRO A CD 1 ATOM 2599 N N . GLY A 1 341 ? 26.734 -26.909 -1.019 1.00 23.09 ? 369 GLY A N 1 ATOM 2600 C CA . GLY A 1 341 ? 26.573 -27.501 -2.342 1.00 22.39 ? 369 GLY A CA 1 ATOM 2601 C C . GLY A 1 341 ? 27.745 -28.433 -2.575 1.00 22.52 ? 369 GLY A C 1 ATOM 2602 O O . GLY A 1 341 ? 28.635 -28.543 -1.712 1.00 22.60 ? 369 GLY A O 1 ATOM 2603 N N . VAL A 1 342 ? 27.750 -29.098 -3.730 1.00 22.06 ? 370 VAL A N 1 ATOM 2604 C CA . VAL A 1 342 ? 28.817 -30.010 -4.103 1.00 21.72 ? 370 VAL A CA 1 ATOM 2605 C C . VAL A 1 342 ? 30.148 -29.275 -4.252 1.00 22.57 ? 370 VAL A C 1 ATOM 2606 O O . VAL A 1 342 ? 31.168 -29.713 -3.702 1.00 23.08 ? 370 VAL A O 1 ATOM 2607 C CB . VAL A 1 342 ? 28.475 -30.762 -5.409 1.00 21.95 ? 370 VAL A CB 1 ATOM 2608 C CG1 . VAL A 1 342 ? 29.667 -31.605 -5.883 1.00 20.58 ? 370 VAL A CG1 1 ATOM 2609 C CG2 . VAL A 1 342 ? 27.222 -31.642 -5.223 1.00 20.71 ? 370 VAL A CG2 1 ATOM 2610 N N . VAL A 1 343 ? 30.120 -28.182 -5.016 1.00 23.20 ? 371 VAL A N 1 ATOM 2611 C CA . VAL A 1 343 ? 31.211 -27.226 -5.180 1.00 23.87 ? 371 VAL A CA 1 ATOM 2612 C C . VAL A 1 343 ? 30.544 -25.878 -4.911 1.00 25.00 ? 371 VAL A C 1 ATOM 2613 O O . VAL A 1 343 ? 29.610 -25.515 -5.605 1.00 25.81 ? 371 VAL A O 1 ATOM 2614 C CB . VAL A 1 343 ? 31.771 -27.258 -6.626 1.00 23.56 ? 371 VAL A CB 1 ATOM 2615 C CG1 . VAL A 1 343 ? 32.756 -26.109 -6.870 1.00 23.86 ? 371 VAL A CG1 1 ATOM 2616 C CG2 . VAL A 1 343 ? 32.434 -28.591 -6.924 1.00 23.02 ? 371 VAL A CG2 1 ATOM 2617 N N . THR A 1 344 ? 31.013 -25.128 -3.926 1.00 26.11 ? 372 THR A N 1 ATOM 2618 C CA . THR A 1 344 ? 30.216 -24.057 -3.364 1.00 27.23 ? 372 THR A CA 1 ATOM 2619 C C . THR A 1 344 ? 31.155 -22.977 -2.836 1.00 27.94 ? 372 THR A C 1 ATOM 2620 O O . THR A 1 344 ? 32.296 -23.286 -2.513 1.00 28.70 ? 372 THR A O 1 ATOM 2621 C CB . THR A 1 344 ? 29.267 -24.641 -2.267 1.00 27.59 ? 372 THR A CB 1 ATOM 2622 O OG1 . THR A 1 344 ? 28.269 -23.684 -1.891 1.00 29.12 ? 372 THR A OG1 1 ATOM 2623 C CG2 . THR A 1 344 ? 30.039 -25.110 -1.019 1.00 26.98 ? 372 THR A CG2 1 ATOM 2624 N N . ASN A 1 345 ? 30.700 -21.720 -2.787 1.00 28.44 ? 373 ASN A N 1 ATOM 2625 C CA . ASN A 1 345 ? 31.540 -20.573 -2.344 1.00 29.11 ? 373 ASN A CA 1 ATOM 2626 C C . ASN A 1 345 ? 31.996 -20.625 -0.900 1.00 29.18 ? 373 ASN A C 1 ATOM 2627 O O . ASN A 1 345 ? 33.074 -20.124 -0.564 1.00 29.49 ? 373 ASN A O 1 ATOM 2628 C CB . ASN A 1 345 ? 30.789 -19.233 -2.458 1.00 29.31 ? 373 ASN A CB 1 ATOM 2629 C CG . ASN A 1 345 ? 30.441 -18.857 -3.882 1.00 32.04 ? 373 ASN A CG 1 ATOM 2630 O OD1 . ASN A 1 345 ? 31.274 -18.960 -4.799 1.00 35.01 ? 373 ASN A OD1 1 ATOM 2631 N ND2 . ASN A 1 345 ? 29.203 -18.393 -4.083 1.00 32.58 ? 373 ASN A ND2 1 ATOM 2632 N N . GLU A 1 346 ? 31.136 -21.157 -0.032 1.00 29.20 ? 374 GLU A N 1 ATOM 2633 C CA . GLU A 1 346 ? 31.270 -20.914 1.396 1.00 29.01 ? 374 GLU A CA 1 ATOM 2634 C C . GLU A 1 346 ? 30.919 -22.151 2.175 1.00 28.27 ? 374 GLU A C 1 ATOM 2635 O O . GLU A 1 346 ? 30.156 -22.987 1.706 1.00 28.17 ? 374 GLU A O 1 ATOM 2636 C CB . GLU A 1 346 ? 30.345 -19.765 1.832 1.00 29.42 ? 374 GLU A CB 1 ATOM 2637 C CG . GLU A 1 346 ? 30.958 -18.358 1.745 1.00 32.13 ? 374 GLU A CG 1 ATOM 2638 C CD . GLU A 1 346 ? 30.129 -17.304 2.485 1.00 36.34 ? 374 GLU A CD 1 ATOM 2639 O OE1 . GLU A 1 346 ? 30.256 -17.152 3.733 1.00 35.96 ? 374 GLU A OE1 1 ATOM 2640 O OE2 . GLU A 1 346 ? 29.328 -16.634 1.804 1.00 38.94 ? 374 GLU A OE2 1 ATOM 2641 N N . ILE A 1 347 ? 31.510 -22.289 3.353 1.00 27.52 ? 375 ILE A N 1 ATOM 2642 C CA . ILE A 1 347 ? 30.852 -23.043 4.409 1.00 26.68 ? 375 ILE A CA 1 ATOM 2643 C C . ILE A 1 347 ? 30.762 -22.093 5.576 1.00 26.67 ? 375 ILE A C 1 ATOM 2644 O O . ILE A 1 347 ? 31.727 -21.929 6.337 1.00 26.95 ? 375 ILE A O 1 ATOM 2645 C CB . ILE A 1 347 ? 31.560 -24.333 4.820 1.00 26.50 ? 375 ILE A CB 1 ATOM 2646 C CG1 . ILE A 1 347 ? 31.658 -25.299 3.631 1.00 25.70 ? 375 ILE A CG1 1 ATOM 2647 C CG2 . ILE A 1 347 ? 30.800 -24.971 5.970 1.00 25.64 ? 375 ILE A CG2 1 ATOM 2648 C CD1 . ILE A 1 347 ? 32.278 -26.642 3.955 1.00 22.44 ? 375 ILE A CD1 1 ATOM 2649 N N . PRO A 1 348 ? 29.617 -21.418 5.698 1.00 26.34 ? 376 PRO A N 1 ATOM 2650 C CA . PRO A 1 348 ? 29.430 -20.586 6.883 1.00 26.12 ? 376 PRO A CA 1 ATOM 2651 C C . PRO A 1 348 ? 29.215 -21.480 8.110 1.00 25.71 ? 376 PRO A C 1 ATOM 2652 O O . PRO A 1 348 ? 28.746 -22.630 7.974 1.00 24.08 ? 376 PRO A O 1 ATOM 2653 C CB . PRO A 1 348 ? 28.158 -19.765 6.564 1.00 26.29 ? 376 PRO A CB 1 ATOM 2654 C CG . PRO A 1 348 ? 27.693 -20.208 5.169 1.00 26.68 ? 376 PRO A CG 1 ATOM 2655 C CD . PRO A 1 348 ? 28.414 -21.490 4.852 1.00 26.26 ? 376 PRO A CD 1 ATOM 2656 N N . LEU A 1 349 ? 29.558 -20.942 9.288 1.00 25.81 ? 377 LEU A N 1 ATOM 2657 C CA . LEU A 1 349 ? 29.350 -21.640 10.558 1.00 26.08 ? 377 LEU A CA 1 ATOM 2658 C C . LEU A 1 349 ? 27.960 -22.251 10.655 1.00 27.29 ? 377 LEU A C 1 ATOM 2659 O O . LEU A 1 349 ? 27.822 -23.412 11.065 1.00 28.12 ? 377 LEU A O 1 ATOM 2660 C CB . LEU A 1 349 ? 29.586 -20.716 11.734 1.00 25.87 ? 377 LEU A CB 1 ATOM 2661 C CG . LEU A 1 349 ? 29.739 -21.357 13.109 1.00 25.58 ? 377 LEU A CG 1 ATOM 2662 C CD1 . LEU A 1 349 ? 31.010 -22.189 13.125 1.00 26.31 ? 377 LEU A CD1 1 ATOM 2663 C CD2 . LEU A 1 349 ? 29.809 -20.259 14.182 1.00 24.48 ? 377 LEU A CD2 1 ATOM 2664 N N . SER A 1 350 ? 26.939 -21.494 10.245 1.00 27.90 ? 378 SER A N 1 ATOM 2665 C CA . SER A 1 350 ? 25.561 -21.944 10.331 1.00 28.85 ? 378 SER A CA 1 ATOM 2666 C C . SER A 1 350 ? 25.259 -23.201 9.506 1.00 29.34 ? 378 SER A C 1 ATOM 2667 O O . SER A 1 350 ? 24.347 -23.948 9.855 1.00 30.03 ? 378 SER A O 1 ATOM 2668 C CB . SER A 1 350 ? 24.601 -20.817 9.951 1.00 29.20 ? 378 SER A CB 1 ATOM 2669 O OG . SER A 1 350 ? 24.544 -20.651 8.536 1.00 30.08 ? 378 SER A OG 1 ATOM 2670 N N . ASP A 1 351 ? 26.005 -23.443 8.427 1.00 29.95 ? 379 ASP A N 1 ATOM 2671 C CA . ASP A 1 351 ? 25.859 -24.703 7.672 1.00 30.27 ? 379 ASP A CA 1 ATOM 2672 C C . ASP A 1 351 ? 26.412 -25.925 8.430 1.00 30.04 ? 379 ASP A C 1 ATOM 2673 O O . ASP A 1 351 ? 25.763 -26.975 8.490 1.00 30.17 ? 379 ASP A O 1 ATOM 2674 C CB . ASP A 1 351 ? 26.503 -24.633 6.284 1.00 30.57 ? 379 ASP A CB 1 ATOM 2675 C CG . ASP A 1 351 ? 26.137 -25.836 5.419 1.00 32.70 ? 379 ASP A CG 1 ATOM 2676 O OD1 . ASP A 1 351 ? 24.940 -25.931 5.069 1.00 36.30 ? 379 ASP A OD1 1 ATOM 2677 O OD2 . ASP A 1 351 ? 27.012 -26.693 5.104 1.00 33.44 ? 379 ASP A OD2 1 ATOM 2678 N N . ALA A 1 352 ? 27.612 -25.798 8.987 1.00 29.71 ? 380 ALA A N 1 ATOM 2679 C CA . ALA A 1 352 ? 28.161 -26.861 9.838 1.00 29.68 ? 380 ALA A CA 1 ATOM 2680 C C . ALA A 1 352 ? 27.317 -27.090 11.092 1.00 29.29 ? 380 ALA A C 1 ATOM 2681 O O . ALA A 1 352 ? 27.229 -28.199 11.569 1.00 29.48 ? 380 ALA A O 1 ATOM 2682 C CB . ALA A 1 352 ? 29.603 -26.561 10.217 1.00 29.69 ? 380 ALA A CB 1 ATOM 2683 N N . GLN A 1 353 ? 26.699 -26.043 11.620 1.00 29.33 ? 381 GLN A N 1 ATOM 2684 C CA . GLN A 1 353 ? 25.827 -26.191 12.781 1.00 29.70 ? 381 GLN A CA 1 ATOM 2685 C C . GLN A 1 353 ? 24.587 -27.038 12.459 1.00 29.12 ? 381 GLN A C 1 ATOM 2686 O O . GLN A 1 353 ? 24.211 -27.932 13.213 1.00 28.59 ? 381 GLN A O 1 ATOM 2687 C CB . GLN A 1 353 ? 25.419 -24.824 13.340 1.00 30.04 ? 381 GLN A CB 1 ATOM 2688 C CG . GLN A 1 353 ? 24.646 -24.961 14.661 1.00 32.89 ? 381 GLN A CG 1 ATOM 2689 C CD . GLN A 1 353 ? 23.709 -23.804 14.957 1.00 35.41 ? 381 GLN A CD 1 ATOM 2690 O OE1 . GLN A 1 353 ? 23.370 -23.004 14.080 1.00 38.29 ? 381 GLN A OE1 1 ATOM 2691 N NE2 . GLN A 1 353 ? 23.274 -23.721 16.204 1.00 36.09 ? 381 GLN A NE2 1 ATOM 2692 N N . LEU A 1 354 ? 23.971 -26.750 11.322 1.00 28.93 ? 382 LEU A N 1 ATOM 2693 C CA . LEU A 1 354 ? 22.811 -27.480 10.858 1.00 28.82 ? 382 LEU A CA 1 ATOM 2694 C C . LEU A 1 354 ? 23.101 -28.975 10.698 1.00 28.93 ? 382 LEU A C 1 ATOM 2695 O O . LEU A 1 354 ? 22.362 -29.821 11.222 1.00 30.01 ? 382 LEU A O 1 ATOM 2696 C CB . LEU A 1 354 ? 22.353 -26.884 9.534 1.00 28.82 ? 382 LEU A CB 1 ATOM 2697 C CG . LEU A 1 354 ? 21.193 -27.546 8.803 1.00 29.20 ? 382 LEU A CG 1 ATOM 2698 C CD1 . LEU A 1 354 ? 19.872 -27.315 9.550 1.00 26.67 ? 382 LEU A CD1 1 ATOM 2699 C CD2 . LEU A 1 354 ? 21.161 -26.977 7.386 1.00 28.24 ? 382 LEU A CD2 1 ATOM 2700 N N . ILE A 1 355 ? 24.183 -29.291 9.984 1.00 28.36 ? 383 ILE A N 1 ATOM 2701 C CA . ILE A 1 355 ? 24.549 -30.669 9.643 1.00 27.13 ? 383 ILE A CA 1 ATOM 2702 C C . ILE A 1 355 ? 25.100 -31.422 10.858 1.00 27.11 ? 383 ILE A C 1 ATOM 2703 O O . ILE A 1 355 ? 24.734 -32.567 11.113 1.00 26.88 ? 383 ILE A O 1 ATOM 2704 C CB . ILE A 1 355 ? 25.543 -30.663 8.453 1.00 27.03 ? 383 ILE A CB 1 ATOM 2705 C CG1 . ILE A 1 355 ? 24.914 -29.927 7.257 1.00 26.22 ? 383 ILE A CG1 1 ATOM 2706 C CG2 . ILE A 1 355 ? 26.007 -32.075 8.078 1.00 25.76 ? 383 ILE A CG2 1 ATOM 2707 C CD1 . ILE A 1 355 ? 23.717 -30.627 6.645 1.00 23.78 ? 383 ILE A CD1 1 ATOM 2708 N N . SER A 1 356 ? 25.958 -30.769 11.626 1.00 26.75 ? 384 SER A N 1 ATOM 2709 C CA . SER A 1 356 ? 26.433 -31.365 12.856 1.00 27.06 ? 384 SER A CA 1 ATOM 2710 C C . SER A 1 356 ? 25.278 -31.713 13.789 1.00 27.46 ? 384 SER A C 1 ATOM 2711 O O . SER A 1 356 ? 25.377 -32.656 14.585 1.00 27.65 ? 384 SER A O 1 ATOM 2712 C CB . SER A 1 356 ? 27.381 -30.417 13.565 1.00 26.88 ? 384 SER A CB 1 ATOM 2713 O OG . SER A 1 356 ? 27.764 -30.952 14.812 1.00 27.38 ? 384 SER A OG 1 ATOM 2714 N N . GLY A 1 357 ? 24.201 -30.929 13.704 1.00 27.70 ? 385 GLY A N 1 ATOM 2715 C CA . GLY A 1 357 ? 23.009 -31.136 14.519 1.00 28.09 ? 385 GLY A CA 1 ATOM 2716 C C . GLY A 1 357 ? 22.215 -32.357 14.083 1.00 28.44 ? 385 GLY A C 1 ATOM 2717 O O . GLY A 1 357 ? 21.760 -33.145 14.912 1.00 29.00 ? 385 GLY A O 1 ATOM 2718 N N . ILE A 1 358 ? 22.044 -32.514 12.777 1.00 28.32 ? 386 ILE A N 1 ATOM 2719 C CA . ILE A 1 358 ? 21.370 -33.676 12.217 1.00 27.92 ? 386 ILE A CA 1 ATOM 2720 C C . ILE A 1 358 ? 22.105 -34.975 12.562 1.00 28.17 ? 386 ILE A C 1 ATOM 2721 O O . ILE A 1 358 ? 21.474 -35.990 12.871 1.00 28.51 ? 386 ILE A O 1 ATOM 2722 C CB . ILE A 1 358 ? 21.197 -33.479 10.712 1.00 27.92 ? 386 ILE A CB 1 ATOM 2723 C CG1 . ILE A 1 358 ? 20.108 -32.432 10.495 1.00 27.65 ? 386 ILE A CG1 1 ATOM 2724 C CG2 . ILE A 1 358 ? 20.849 -34.782 10.003 1.00 27.40 ? 386 ILE A CG2 1 ATOM 2725 C CD1 . ILE A 1 358 ? 20.143 -31.791 9.145 1.00 28.25 ? 386 ILE A CD1 1 ATOM 2726 N N . TYR A 1 359 ? 23.437 -34.922 12.569 1.00 28.27 ? 387 TYR A N 1 ATOM 2727 C CA . TYR A 1 359 ? 24.267 -36.086 12.911 1.00 28.12 ? 387 TYR A CA 1 ATOM 2728 C C . TYR A 1 359 ? 24.700 -36.254 14.377 1.00 29.01 ? 387 TYR A C 1 ATOM 2729 O O . TYR A 1 359 ? 25.396 -37.224 14.690 1.00 29.21 ? 387 TYR A O 1 ATOM 2730 C CB . TYR A 1 359 ? 25.487 -36.153 11.983 1.00 27.67 ? 387 TYR A CB 1 ATOM 2731 C CG . TYR A 1 359 ? 25.121 -36.686 10.622 1.00 25.19 ? 387 TYR A CG 1 ATOM 2732 C CD1 . TYR A 1 359 ? 25.054 -38.058 10.396 1.00 24.25 ? 387 TYR A CD1 1 ATOM 2733 C CD2 . TYR A 1 359 ? 24.814 -35.826 9.566 1.00 23.06 ? 387 TYR A CD2 1 ATOM 2734 C CE1 . TYR A 1 359 ? 24.701 -38.574 9.143 1.00 24.22 ? 387 TYR A CE1 1 ATOM 2735 C CE2 . TYR A 1 359 ? 24.462 -36.334 8.296 1.00 22.90 ? 387 TYR A CE2 1 ATOM 2736 C CZ . TYR A 1 359 ? 24.398 -37.708 8.104 1.00 23.11 ? 387 TYR A CZ 1 ATOM 2737 O OH . TYR A 1 359 ? 24.045 -38.236 6.891 1.00 22.55 ? 387 TYR A OH 1 ATOM 2738 N N . ASP A 1 360 ? 24.293 -35.341 15.267 1.00 29.71 ? 388 ASP A N 1 ATOM 2739 C CA . ASP A 1 360 ? 24.720 -35.389 16.676 1.00 30.72 ? 388 ASP A CA 1 ATOM 2740 C C . ASP A 1 360 ? 26.225 -35.757 16.784 1.00 29.40 ? 388 ASP A C 1 ATOM 2741 O O . ASP A 1 360 ? 26.585 -36.673 17.535 1.00 29.18 ? 388 ASP A O 1 ATOM 2742 C CB . ASP A 1 360 ? 23.840 -36.365 17.526 1.00 31.65 ? 388 ASP A CB 1 ATOM 2743 C CG . ASP A 1 360 ? 23.602 -35.846 18.983 1.00 36.88 ? 388 ASP A CG 1 ATOM 2744 O OD1 . ASP A 1 360 ? 23.017 -34.745 19.098 1.00 41.37 ? 388 ASP A OD1 1 ATOM 2745 O OD2 . ASP A 1 360 ? 23.984 -36.490 20.021 1.00 40.97 ? 388 ASP A OD2 1 ATOM 2746 N N . ARG A 1 361 ? 27.078 -35.065 16.013 1.00 27.66 ? 389 ARG A N 1 ATOM 2747 C CA . ARG A 1 361 ? 28.537 -35.291 16.046 1.00 26.36 ? 389 ARG A CA 1 ATOM 2748 C C . ARG A 1 361 ? 29.354 -34.182 15.364 1.00 25.83 ? 389 ARG A C 1 ATOM 2749 O O . ARG A 1 361 ? 28.830 -33.384 14.581 1.00 25.60 ? 389 ARG A O 1 ATOM 2750 C CB . ARG A 1 361 ? 28.903 -36.625 15.390 1.00 25.73 ? 389 ARG A CB 1 ATOM 2751 C CG . ARG A 1 361 ? 28.932 -36.539 13.879 1.00 25.23 ? 389 ARG A CG 1 ATOM 2752 C CD . ARG A 1 361 ? 28.853 -37.897 13.215 1.00 24.95 ? 389 ARG A CD 1 ATOM 2753 N NE . ARG A 1 361 ? 27.594 -38.569 13.522 1.00 24.36 ? 389 ARG A NE 1 ATOM 2754 C CZ . ARG A 1 361 ? 27.427 -39.888 13.506 1.00 25.08 ? 389 ARG A CZ 1 ATOM 2755 N NH1 . ARG A 1 361 ? 28.439 -40.694 13.192 1.00 25.85 ? 389 ARG A NH1 1 ATOM 2756 N NH2 . ARG A 1 361 ? 26.244 -40.420 13.788 1.00 22.97 ? 389 ARG A NH2 1 ATOM 2757 N N . ASN A 1 362 ? 30.654 -34.165 15.648 1.00 24.94 ? 390 ASN A N 1 ATOM 2758 C CA . ASN A 1 362 ? 31.602 -33.409 14.840 1.00 24.16 ? 390 ASN A CA 1 ATOM 2759 C C . ASN A 1 362 ? 31.724 -33.986 13.432 1.00 23.21 ? 390 ASN A C 1 ATOM 2760 O O . ASN A 1 362 ? 31.861 -35.203 13.263 1.00 22.75 ? 390 ASN A O 1 ATOM 2761 C CB . ASN A 1 362 ? 32.951 -33.375 15.537 1.00 24.15 ? 390 ASN A CB 1 ATOM 2762 C CG . ASN A 1 362 ? 32.880 -32.626 16.848 1.00 25.55 ? 390 ASN A CG 1 ATOM 2763 O OD1 . ASN A 1 362 ? 33.289 -33.135 17.899 1.00 27.15 ? 390 ASN A OD1 1 ATOM 2764 N ND2 . ASN A 1 362 ? 32.321 -31.419 16.804 1.00 26.05 ? 390 ASN A ND2 1 ATOM 2765 N N . MET A 1 363 ? 31.657 -33.106 12.437 1.00 22.22 ? 391 MET A N 1 ATOM 2766 C CA . MET A 1 363 ? 31.596 -33.507 11.033 1.00 21.67 ? 391 MET A CA 1 ATOM 2767 C C . MET A 1 363 ? 32.978 -33.561 10.383 1.00 21.39 ? 391 MET A C 1 ATOM 2768 O O . MET A 1 363 ? 33.967 -33.063 10.947 1.00 22.02 ? 391 MET A O 1 ATOM 2769 C CB . MET A 1 363 ? 30.696 -32.552 10.243 1.00 21.58 ? 391 MET A CB 1 ATOM 2770 C CG . MET A 1 363 ? 29.228 -32.615 10.604 1.00 22.56 ? 391 MET A CG 1 ATOM 2771 S SD . MET A 1 363 ? 28.520 -34.279 10.504 1.00 25.76 ? 391 MET A SD 1 ATOM 2772 C CE . MET A 1 363 ? 28.514 -34.585 8.746 1.00 21.85 ? 391 MET A CE 1 ATOM 2773 N N . ALA A 1 364 ? 33.036 -34.184 9.210 1.00 20.22 ? 392 ALA A N 1 ATOM 2774 C CA . ALA A 1 364 ? 34.205 -34.161 8.361 1.00 19.58 ? 392 ALA A CA 1 ATOM 2775 C C . ALA A 1 364 ? 33.841 -33.474 7.043 1.00 19.61 ? 392 ALA A C 1 ATOM 2776 O O . ALA A 1 364 ? 32.737 -33.665 6.512 1.00 19.93 ? 392 ALA A O 1 ATOM 2777 C CB . ALA A 1 364 ? 34.699 -35.577 8.116 1.00 19.08 ? 392 ALA A CB 1 ATOM 2778 N N . VAL A 1 365 ? 34.766 -32.680 6.516 1.00 19.21 ? 393 VAL A N 1 ATOM 2779 C CA . VAL A 1 365 ? 34.538 -31.965 5.274 1.00 19.64 ? 393 VAL A CA 1 ATOM 2780 C C . VAL A 1 365 ? 35.255 -32.647 4.137 1.00 19.46 ? 393 VAL A C 1 ATOM 2781 O O . VAL A 1 365 ? 36.425 -33.015 4.262 1.00 19.90 ? 393 VAL A O 1 ATOM 2782 C CB . VAL A 1 365 ? 35.063 -30.522 5.347 1.00 20.08 ? 393 VAL A CB 1 ATOM 2783 C CG1 . VAL A 1 365 ? 34.891 -29.811 4.003 1.00 20.50 ? 393 VAL A CG1 1 ATOM 2784 C CG2 . VAL A 1 365 ? 34.346 -29.744 6.458 1.00 20.83 ? 393 VAL A CG2 1 ATOM 2785 N N . TRP A 1 366 ? 34.555 -32.813 3.023 1.00 18.97 ? 394 TRP A N 1 ATOM 2786 C CA . TRP A 1 366 ? 35.178 -33.201 1.773 1.00 17.89 ? 394 TRP A CA 1 ATOM 2787 C C . TRP A 1 366 ? 34.999 -31.933 0.970 1.00 18.39 ? 394 TRP A C 1 ATOM 2788 O O . TRP A 1 366 ? 33.895 -31.628 0.491 1.00 18.70 ? 394 TRP A O 1 ATOM 2789 C CB . TRP A 1 366 ? 34.413 -34.371 1.182 1.00 17.25 ? 394 TRP A CB 1 ATOM 2790 C CG . TRP A 1 366 ? 34.764 -34.786 -0.216 1.00 16.33 ? 394 TRP A CG 1 ATOM 2791 C CD1 . TRP A 1 366 ? 35.021 -33.972 -1.292 1.00 15.24 ? 394 TRP A CD1 1 ATOM 2792 C CD2 . TRP A 1 366 ? 34.809 -36.134 -0.719 1.00 15.35 ? 394 TRP A CD2 1 ATOM 2793 N NE1 . TRP A 1 366 ? 35.252 -34.733 -2.415 1.00 14.55 ? 394 TRP A NE1 1 ATOM 2794 C CE2 . TRP A 1 366 ? 35.125 -36.059 -2.095 1.00 13.27 ? 394 TRP A CE2 1 ATOM 2795 C CE3 . TRP A 1 366 ? 34.623 -37.396 -0.134 1.00 15.38 ? 394 TRP A CE3 1 ATOM 2796 C CZ2 . TRP A 1 366 ? 35.280 -37.190 -2.892 1.00 13.01 ? 394 TRP A CZ2 1 ATOM 2797 C CZ3 . TRP A 1 366 ? 34.775 -38.534 -0.939 1.00 16.18 ? 394 TRP A CZ3 1 ATOM 2798 C CH2 . TRP A 1 366 ? 35.100 -38.416 -2.306 1.00 14.29 ? 394 TRP A CH2 1 ATOM 2799 N N . TRP A 1 367 ? 36.078 -31.171 0.862 1.00 18.31 ? 395 TRP A N 1 ATOM 2800 C CA . TRP A 1 367 ? 36.059 -29.875 0.206 1.00 18.40 ? 395 TRP A CA 1 ATOM 2801 C C . TRP A 1 367 ? 36.519 -29.996 -1.242 1.00 18.78 ? 395 TRP A C 1 ATOM 2802 O O . TRP A 1 367 ? 37.700 -30.260 -1.515 1.00 18.64 ? 395 TRP A O 1 ATOM 2803 C CB . TRP A 1 367 ? 36.928 -28.880 0.972 1.00 18.25 ? 395 TRP A CB 1 ATOM 2804 C CG . TRP A 1 367 ? 36.845 -27.450 0.491 1.00 19.00 ? 395 TRP A CG 1 ATOM 2805 C CD1 . TRP A 1 367 ? 37.882 -26.673 0.023 1.00 19.76 ? 395 TRP A CD1 1 ATOM 2806 C CD2 . TRP A 1 367 ? 35.675 -26.617 0.452 1.00 19.21 ? 395 TRP A CD2 1 ATOM 2807 N NE1 . TRP A 1 367 ? 37.421 -25.409 -0.302 1.00 20.36 ? 395 TRP A NE1 1 ATOM 2808 C CE2 . TRP A 1 367 ? 36.073 -25.355 -0.054 1.00 19.26 ? 395 TRP A CE2 1 ATOM 2809 C CE3 . TRP A 1 367 ? 34.332 -26.814 0.790 1.00 18.51 ? 395 TRP A CE3 1 ATOM 2810 C CZ2 . TRP A 1 367 ? 35.178 -24.307 -0.225 1.00 19.87 ? 395 TRP A CZ2 1 ATOM 2811 C CZ3 . TRP A 1 367 ? 33.447 -25.766 0.625 1.00 19.35 ? 395 TRP A CZ3 1 ATOM 2812 C CH2 . TRP A 1 367 ? 33.872 -24.527 0.126 1.00 18.68 ? 395 TRP A CH2 1 ATOM 2813 N N . ASN A 1 368 ? 35.571 -29.799 -2.161 1.00 18.83 ? 396 ASN A N 1 ATOM 2814 C CA . ASN A 1 368 ? 35.814 -29.890 -3.592 1.00 18.81 ? 396 ASN A CA 1 ATOM 2815 C C . ASN A 1 368 ? 36.442 -28.638 -4.214 1.00 19.03 ? 396 ASN A C 1 ATOM 2816 O O . ASN A 1 368 ? 35.858 -27.957 -5.067 1.00 18.59 ? 396 ASN A O 1 ATOM 2817 C CB . ASN A 1 368 ? 34.541 -30.302 -4.298 1.00 18.36 ? 396 ASN A CB 1 ATOM 2818 C CG . ASN A 1 368 ? 34.281 -31.767 -4.163 1.00 19.94 ? 396 ASN A CG 1 ATOM 2819 O OD1 . ASN A 1 368 ? 35.199 -32.579 -4.284 1.00 23.69 ? 396 ASN A OD1 1 ATOM 2820 N ND2 . ASN A 1 368 ? 33.028 -32.136 -3.927 1.00 19.61 ? 396 ASN A ND2 1 ATOM 2821 N N . TYR A 1 369 ? 37.655 -28.364 -3.750 1.00 19.01 ? 397 TYR A N 1 ATOM 2822 C CA . TYR A 1 369 ? 38.556 -27.376 -4.307 1.00 18.67 ? 397 TYR A CA 1 ATOM 2823 C C . TYR A 1 369 ? 39.927 -27.836 -3.809 1.00 18.95 ? 397 TYR A C 1 ATOM 2824 O O . TYR A 1 369 ? 40.080 -28.120 -2.613 1.00 18.92 ? 397 TYR A O 1 ATOM 2825 C CB . TYR A 1 369 ? 38.208 -25.989 -3.781 1.00 17.95 ? 397 TYR A CB 1 ATOM 2826 C CG . TYR A 1 369 ? 38.963 -24.851 -4.438 1.00 19.19 ? 397 TYR A CG 1 ATOM 2827 C CD1 . TYR A 1 369 ? 40.259 -24.516 -4.029 1.00 19.77 ? 397 TYR A CD1 1 ATOM 2828 C CD2 . TYR A 1 369 ? 38.386 -24.092 -5.465 1.00 19.33 ? 397 TYR A CD2 1 ATOM 2829 C CE1 . TYR A 1 369 ? 40.965 -23.460 -4.631 1.00 19.63 ? 397 TYR A CE1 1 ATOM 2830 C CE2 . TYR A 1 369 ? 39.088 -23.029 -6.066 1.00 18.56 ? 397 TYR A CE2 1 ATOM 2831 C CZ . TYR A 1 369 ? 40.377 -22.732 -5.640 1.00 19.58 ? 397 TYR A CZ 1 ATOM 2832 O OH . TYR A 1 369 ? 41.096 -21.703 -6.196 1.00 20.55 ? 397 TYR A OH 1 ATOM 2833 N N . PRO A 1 370 ? 40.942 -27.902 -4.696 1.00 19.05 ? 398 PRO A N 1 ATOM 2834 C CA . PRO A 1 370 ? 40.990 -27.439 -6.073 1.00 18.76 ? 398 PRO A CA 1 ATOM 2835 C C . PRO A 1 370 ? 40.536 -28.402 -7.170 1.00 18.60 ? 398 PRO A C 1 ATOM 2836 O O . PRO A 1 370 ? 40.841 -28.139 -8.316 1.00 19.00 ? 398 PRO A O 1 ATOM 2837 C CB . PRO A 1 370 ? 42.477 -27.158 -6.271 1.00 19.37 ? 398 PRO A CB 1 ATOM 2838 C CG . PRO A 1 370 ? 43.152 -28.189 -5.423 1.00 19.35 ? 398 PRO A CG 1 ATOM 2839 C CD . PRO A 1 370 ? 42.277 -28.330 -4.220 1.00 18.91 ? 398 PRO A CD 1 ATOM 2840 N N . VAL A 1 371 ? 39.842 -29.494 -6.856 1.00 18.15 ? 399 VAL A N 1 ATOM 2841 C CA . VAL A 1 371 ? 39.396 -30.427 -7.895 1.00 17.52 ? 399 VAL A CA 1 ATOM 2842 C C . VAL A 1 371 ? 38.819 -29.657 -9.091 1.00 17.90 ? 399 VAL A C 1 ATOM 2843 O O . VAL A 1 371 ? 38.148 -28.631 -8.912 1.00 18.12 ? 399 VAL A O 1 ATOM 2844 C CB . VAL A 1 371 ? 38.381 -31.487 -7.357 1.00 17.52 ? 399 VAL A CB 1 ATOM 2845 C CG1 . VAL A 1 371 ? 37.224 -30.838 -6.631 1.00 17.36 ? 399 VAL A CG1 1 ATOM 2846 C CG2 . VAL A 1 371 ? 37.865 -32.391 -8.487 1.00 16.96 ? 399 VAL A CG2 1 ATOM 2847 N N . THR A 1 372 ? 39.111 -30.130 -10.300 1.00 17.79 ? 400 THR A N 1 ATOM 2848 C CA . THR A 1 372 ? 38.624 -29.496 -11.522 1.00 17.69 ? 400 THR A CA 1 ATOM 2849 C C . THR A 1 372 ? 38.060 -30.511 -12.515 1.00 18.14 ? 400 THR A C 1 ATOM 2850 O O . THR A 1 372 ? 38.053 -30.249 -13.718 1.00 18.61 ? 400 THR A O 1 ATOM 2851 C CB . THR A 1 372 ? 39.739 -28.762 -12.258 1.00 17.20 ? 400 THR A CB 1 ATOM 2852 O OG1 . THR A 1 372 ? 40.802 -29.679 -12.494 1.00 18.31 ? 400 THR A OG1 1 ATOM 2853 C CG2 . THR A 1 372 ? 40.274 -27.614 -11.472 1.00 16.98 ? 400 THR A CG2 1 ATOM 2854 N N . ASP A 1 373 ? 37.577 -31.654 -12.043 1.00 18.15 ? 401 ASP A N 1 ATOM 2855 C CA . ASP A 1 373 ? 37.097 -32.693 -12.969 1.00 19.23 ? 401 ASP A CA 1 ATOM 2856 C C . ASP A 1 373 ? 35.833 -32.277 -13.731 1.00 19.57 ? 401 ASP A C 1 ATOM 2857 O O . ASP A 1 373 ? 35.513 -32.868 -14.762 1.00 19.25 ? 401 ASP A O 1 ATOM 2858 C CB . ASP A 1 373 ? 36.921 -34.074 -12.295 1.00 18.97 ? 401 ASP A CB 1 ATOM 2859 C CG . ASP A 1 373 ? 35.969 -34.043 -11.104 1.00 19.49 ? 401 ASP A CG 1 ATOM 2860 O OD1 . ASP A 1 373 ? 35.378 -32.982 -10.793 1.00 21.41 ? 401 ASP A OD1 1 ATOM 2861 O OD2 . ASP A 1 373 ? 35.810 -35.091 -10.461 1.00 19.75 ? 401 ASP A OD2 1 ATOM 2862 N N . TYR A 1 374 ? 35.160 -31.243 -13.224 1.00 20.48 ? 402 TYR A N 1 ATOM 2863 C CA . TYR A 1 374 ? 33.882 -30.758 -13.766 1.00 21.12 ? 402 TYR A CA 1 ATOM 2864 C C . TYR A 1 374 ? 34.078 -29.624 -14.765 1.00 21.88 ? 402 TYR A C 1 ATOM 2865 O O . TYR A 1 374 ? 33.110 -29.189 -15.393 1.00 22.34 ? 402 TYR A O 1 ATOM 2866 C CB . TYR A 1 374 ? 32.942 -30.306 -12.638 1.00 20.42 ? 402 TYR A CB 1 ATOM 2867 C CG . TYR A 1 374 ? 33.501 -29.186 -11.812 1.00 20.05 ? 402 TYR A CG 1 ATOM 2868 C CD1 . TYR A 1 374 ? 33.368 -27.858 -12.217 1.00 21.14 ? 402 TYR A CD1 1 ATOM 2869 C CD2 . TYR A 1 374 ? 34.175 -29.444 -10.631 1.00 19.33 ? 402 TYR A CD2 1 ATOM 2870 C CE1 . TYR A 1 374 ? 33.913 -26.820 -11.469 1.00 19.51 ? 402 TYR A CE1 1 ATOM 2871 C CE2 . TYR A 1 374 ? 34.712 -28.427 -9.876 1.00 18.17 ? 402 TYR A CE2 1 ATOM 2872 C CZ . TYR A 1 374 ? 34.583 -27.113 -10.296 1.00 19.80 ? 402 TYR A CZ 1 ATOM 2873 O OH . TYR A 1 374 ? 35.121 -26.087 -9.529 1.00 19.74 ? 402 TYR A OH 1 ATOM 2874 N N . PHE A 1 375 ? 35.327 -29.160 -14.904 1.00 22.26 ? 403 PHE A N 1 ATOM 2875 C CA . PHE A 1 375 ? 35.683 -27.993 -15.725 1.00 22.21 ? 403 PHE A CA 1 ATOM 2876 C C . PHE A 1 375 ? 37.204 -28.016 -15.947 1.00 21.74 ? 403 PHE A C 1 ATOM 2877 O O . PHE A 1 375 ? 37.954 -27.196 -15.421 1.00 21.11 ? 403 PHE A O 1 ATOM 2878 C CB . PHE A 1 375 ? 35.253 -26.715 -15.001 1.00 23.02 ? 403 PHE A CB 1 ATOM 2879 C CG . PHE A 1 375 ? 35.148 -25.511 -15.887 1.00 25.60 ? 403 PHE A CG 1 ATOM 2880 C CD1 . PHE A 1 375 ? 34.210 -25.472 -16.923 1.00 28.31 ? 403 PHE A CD1 1 ATOM 2881 C CD2 . PHE A 1 375 ? 35.946 -24.392 -15.654 1.00 27.31 ? 403 PHE A CD2 1 ATOM 2882 C CE1 . PHE A 1 375 ? 34.089 -24.348 -17.743 1.00 30.03 ? 403 PHE A CE1 1 ATOM 2883 C CE2 . PHE A 1 375 ? 35.843 -23.252 -16.461 1.00 29.41 ? 403 PHE A CE2 1 ATOM 2884 C CZ . PHE A 1 375 ? 34.914 -23.227 -17.517 1.00 30.17 ? 403 PHE A CZ 1 ATOM 2885 N N . LYS A 1 376 ? 37.639 -28.979 -16.749 1.00 21.57 ? 404 LYS A N 1 ATOM 2886 C CA . LYS A 1 376 ? 39.039 -29.372 -16.836 1.00 21.51 ? 404 LYS A CA 1 ATOM 2887 C C . LYS A 1 376 ? 39.933 -28.349 -17.533 1.00 21.52 ? 404 LYS A C 1 ATOM 2888 O O . LYS A 1 376 ? 41.134 -28.495 -17.523 1.00 21.93 ? 404 LYS A O 1 ATOM 2889 C CB . LYS A 1 376 ? 39.170 -30.728 -17.541 1.00 21.26 ? 404 LYS A CB 1 ATOM 2890 C CG . LYS A 1 376 ? 38.607 -31.937 -16.781 1.00 23.18 ? 404 LYS A CG 1 ATOM 2891 C CD . LYS A 1 376 ? 38.867 -33.234 -17.577 1.00 26.32 ? 404 LYS A CD 1 ATOM 2892 C CE . LYS A 1 376 ? 38.632 -34.488 -16.729 1.00 28.65 ? 404 LYS A CE 1 ATOM 2893 N NZ . LYS A 1 376 ? 39.540 -35.623 -17.119 1.00 29.88 ? 404 LYS A NZ 1 ATOM 2894 N N . GLY A 1 377 ? 39.366 -27.316 -18.139 1.00 21.15 ? 405 GLY A N 1 ATOM 2895 C CA . GLY A 1 377 ? 40.184 -26.370 -18.865 1.00 20.00 ? 405 GLY A CA 1 ATOM 2896 C C . GLY A 1 377 ? 40.881 -25.387 -17.952 1.00 19.80 ? 405 GLY A C 1 ATOM 2897 O O . GLY A 1 377 ? 41.827 -24.728 -18.366 1.00 19.70 ? 405 GLY A O 1 ATOM 2898 N N . LYS A 1 378 ? 40.409 -25.278 -16.710 1.00 19.28 ? 406 LYS A N 1 ATOM 2899 C CA . LYS A 1 378 ? 40.962 -24.303 -15.800 1.00 18.87 ? 406 LYS A CA 1 ATOM 2900 C C . LYS A 1 378 ? 41.761 -24.978 -14.701 1.00 19.40 ? 406 LYS A C 1 ATOM 2901 O O . LYS A 1 378 ? 41.415 -26.070 -14.254 1.00 19.47 ? 406 LYS A O 1 ATOM 2902 C CB . LYS A 1 378 ? 39.862 -23.441 -15.193 1.00 18.74 ? 406 LYS A CB 1 ATOM 2903 C CG . LYS A 1 378 ? 40.366 -22.063 -14.793 1.00 19.27 ? 406 LYS A CG 1 ATOM 2904 C CD . LYS A 1 378 ? 39.347 -21.200 -14.080 1.00 18.28 ? 406 LYS A CD 1 ATOM 2905 C CE . LYS A 1 378 ? 40.011 -19.911 -13.596 1.00 18.24 ? 406 LYS A CE 1 ATOM 2906 N NZ . LYS A 1 378 ? 39.011 -18.810 -13.380 1.00 17.70 ? 406 LYS A NZ 1 ATOM 2907 N N . LEU A 1 379 ? 42.849 -24.328 -14.293 1.00 19.31 ? 407 LEU A N 1 ATOM 2908 C CA . LEU A 1 379 ? 43.555 -24.676 -13.082 1.00 18.89 ? 407 LEU A CA 1 ATOM 2909 C C . LEU A 1 379 ? 42.945 -23.921 -11.893 1.00 19.49 ? 407 LEU A C 1 ATOM 2910 O O . LEU A 1 379 ? 42.584 -22.717 -12.008 1.00 19.26 ? 407 LEU A O 1 ATOM 2911 C CB . LEU A 1 379 ? 45.025 -24.319 -13.227 1.00 18.38 ? 407 LEU A CB 1 ATOM 2912 C CG . LEU A 1 379 ? 45.613 -25.024 -14.438 1.00 18.43 ? 407 LEU A CG 1 ATOM 2913 C CD1 . LEU A 1 379 ? 46.999 -24.542 -14.678 1.00 16.93 ? 407 LEU A CD1 1 ATOM 2914 C CD2 . LEU A 1 379 ? 45.563 -26.559 -14.255 1.00 16.99 ? 407 LEU A CD2 1 ATOM 2915 N N . ALA A 1 380 ? 42.820 -24.624 -10.760 1.00 18.99 ? 408 ALA A N 1 ATOM 2916 C CA . ALA A 1 380 ? 42.385 -23.996 -9.523 1.00 18.77 ? 408 ALA A CA 1 ATOM 2917 C C . ALA A 1 380 ? 43.625 -23.736 -8.668 1.00 18.85 ? 408 ALA A C 1 ATOM 2918 O O . ALA A 1 380 ? 44.178 -24.657 -8.077 1.00 19.61 ? 408 ALA A O 1 ATOM 2919 C CB . ALA A 1 380 ? 41.348 -24.875 -8.811 1.00 18.16 ? 408 ALA A CB 1 ATOM 2920 N N . LEU A 1 381 ? 44.079 -22.481 -8.635 1.00 18.77 ? 409 LEU A N 1 ATOM 2921 C CA . LEU A 1 381 ? 45.374 -22.132 -8.057 1.00 18.07 ? 409 LEU A CA 1 ATOM 2922 C C . LEU A 1 381 ? 45.285 -21.109 -6.926 1.00 18.71 ? 409 LEU A C 1 ATOM 2923 O O . LEU A 1 381 ? 46.295 -20.429 -6.603 1.00 18.96 ? 409 LEU A O 1 ATOM 2924 C CB . LEU A 1 381 ? 46.316 -21.598 -9.135 1.00 17.90 ? 409 LEU A CB 1 ATOM 2925 C CG . LEU A 1 381 ? 46.631 -22.467 -10.354 1.00 17.68 ? 409 LEU A CG 1 ATOM 2926 C CD1 . LEU A 1 381 ? 47.655 -21.800 -11.256 1.00 16.71 ? 409 LEU A CD1 1 ATOM 2927 C CD2 . LEU A 1 381 ? 47.124 -23.810 -9.932 1.00 15.85 ? 409 LEU A CD2 1 ATOM 2928 N N . GLY A 1 382 ? 44.102 -20.997 -6.318 1.00 18.26 ? 410 GLY A N 1 ATOM 2929 C CA . GLY A 1 382 ? 43.899 -20.085 -5.202 1.00 18.23 ? 410 GLY A CA 1 ATOM 2930 C C . GLY A 1 382 ? 43.910 -20.778 -3.851 1.00 18.64 ? 410 GLY A C 1 ATOM 2931 O O . GLY A 1 382 ? 44.007 -22.012 -3.774 1.00 18.56 ? 410 GLY A O 1 ATOM 2932 N N . PRO A 1 383 ? 43.749 -19.993 -2.779 1.00 18.62 ? 411 PRO A N 1 ATOM 2933 C CA . PRO A 1 383 ? 43.806 -20.487 -1.414 1.00 18.97 ? 411 PRO A CA 1 ATOM 2934 C C . PRO A 1 383 ? 42.461 -21.055 -0.966 1.00 19.65 ? 411 PRO A C 1 ATOM 2935 O O . PRO A 1 383 ? 41.471 -20.895 -1.671 1.00 19.46 ? 411 PRO A O 1 ATOM 2936 C CB . PRO A 1 383 ? 44.114 -19.222 -0.611 1.00 18.42 ? 411 PRO A CB 1 ATOM 2937 C CG . PRO A 1 383 ? 43.379 -18.161 -1.354 1.00 19.14 ? 411 PRO A CG 1 ATOM 2938 C CD . PRO A 1 383 ? 43.364 -18.570 -2.826 1.00 18.51 ? 411 PRO A CD 1 ATOM 2939 N N . MET A 1 384 ? 42.440 -21.724 0.188 1.00 20.37 ? 412 MET A N 1 ATOM 2940 C CA . MET A 1 384 ? 41.194 -22.007 0.874 1.00 21.09 ? 412 MET A CA 1 ATOM 2941 C C . MET A 1 384 ? 40.465 -20.685 1.042 1.00 21.74 ? 412 MET A C 1 ATOM 2942 O O . MET A 1 384 ? 41.059 -19.700 1.523 1.00 22.48 ? 412 MET A O 1 ATOM 2943 C CB . MET A 1 384 ? 41.465 -22.615 2.247 1.00 20.55 ? 412 MET A CB 1 ATOM 2944 C CG . MET A 1 384 ? 42.058 -23.992 2.207 1.00 20.84 ? 412 MET A CG 1 ATOM 2945 S SD . MET A 1 384 ? 41.066 -25.143 1.260 1.00 19.81 ? 412 MET A SD 1 ATOM 2946 C CE . MET A 1 384 ? 41.954 -25.268 -0.291 1.00 22.04 ? 412 MET A CE 1 ATOM 2947 N N . HIS A 1 385 ? 39.191 -20.660 0.653 1.00 21.96 ? 413 HIS A N 1 ATOM 2948 C CA . HIS A 1 385 ? 38.420 -19.416 0.603 1.00 22.46 ? 413 HIS A CA 1 ATOM 2949 C C . HIS A 1 385 ? 36.950 -19.720 0.860 1.00 22.73 ? 413 HIS A C 1 ATOM 2950 O O . HIS A 1 385 ? 36.408 -20.679 0.322 1.00 21.50 ? 413 HIS A O 1 ATOM 2951 C CB . HIS A 1 385 ? 38.619 -18.724 -0.754 1.00 21.92 ? 413 HIS A CB 1 ATOM 2952 C CG . HIS A 1 385 ? 37.859 -17.445 -0.911 1.00 23.72 ? 413 HIS A CG 1 ATOM 2953 N ND1 . HIS A 1 385 ? 38.320 -16.237 -0.433 1.00 26.00 ? 413 HIS A ND1 1 ATOM 2954 C CD2 . HIS A 1 385 ? 36.682 -17.177 -1.525 1.00 24.83 ? 413 HIS A CD2 1 ATOM 2955 C CE1 . HIS A 1 385 ? 37.454 -15.283 -0.732 1.00 26.27 ? 413 HIS A CE1 1 ATOM 2956 N NE2 . HIS A 1 385 ? 36.448 -15.830 -1.391 1.00 25.30 ? 413 HIS A NE2 1 ATOM 2957 N N . GLY A 1 386 ? 36.321 -18.901 1.706 1.00 23.67 ? 414 GLY A N 1 ATOM 2958 C CA . GLY A 1 386 ? 34.904 -19.077 2.051 1.00 24.28 ? 414 GLY A CA 1 ATOM 2959 C C . GLY A 1 386 ? 34.613 -20.074 3.169 1.00 24.69 ? 414 GLY A C 1 ATOM 2960 O O . GLY A 1 386 ? 33.454 -20.357 3.453 1.00 25.37 ? 414 GLY A O 1 ATOM 2961 N N . LEU A 1 387 ? 35.649 -20.623 3.797 1.00 24.69 ? 415 LEU A N 1 ATOM 2962 C CA . LEU A 1 387 ? 35.460 -21.583 4.870 1.00 24.50 ? 415 LEU A CA 1 ATOM 2963 C C . LEU A 1 387 ? 35.584 -20.828 6.168 1.00 25.12 ? 415 LEU A C 1 ATOM 2964 O O . LEU A 1 387 ? 36.595 -20.146 6.412 1.00 25.08 ? 415 LEU A O 1 ATOM 2965 C CB . LEU A 1 387 ? 36.503 -22.679 4.796 1.00 24.31 ? 415 LEU A CB 1 ATOM 2966 C CG . LEU A 1 387 ? 36.447 -23.590 3.567 1.00 24.30 ? 415 LEU A CG 1 ATOM 2967 C CD1 . LEU A 1 387 ? 37.795 -24.223 3.318 1.00 22.61 ? 415 LEU A CD1 1 ATOM 2968 C CD2 . LEU A 1 387 ? 35.364 -24.658 3.703 1.00 22.84 ? 415 LEU A CD2 1 ATOM 2969 N N . ASP A 1 388 ? 34.546 -20.936 6.993 1.00 25.46 ? 416 ASP A N 1 ATOM 2970 C CA . ASP A 1 388 ? 34.412 -20.109 8.183 1.00 25.94 ? 416 ASP A CA 1 ATOM 2971 C C . ASP A 1 388 ? 35.544 -20.430 9.160 1.00 26.28 ? 416 ASP A C 1 ATOM 2972 O O . ASP A 1 388 ? 35.934 -21.595 9.318 1.00 26.59 ? 416 ASP A O 1 ATOM 2973 C CB . ASP A 1 388 ? 33.043 -20.338 8.831 1.00 26.20 ? 416 ASP A CB 1 ATOM 2974 C CG . ASP A 1 388 ? 32.701 -19.290 9.875 1.00 27.93 ? 416 ASP A CG 1 ATOM 2975 O OD1 . ASP A 1 388 ? 32.102 -18.242 9.501 1.00 30.70 ? 416 ASP A OD1 1 ATOM 2976 O OD2 . ASP A 1 388 ? 33.033 -19.507 11.067 1.00 28.19 ? 416 ASP A OD2 1 ATOM 2977 N N . LYS A 1 389 ? 36.058 -19.402 9.825 1.00 26.04 ? 417 LYS A N 1 ATOM 2978 C CA . LYS A 1 389 ? 37.246 -19.560 10.644 1.00 25.89 ? 417 LYS A CA 1 ATOM 2979 C C . LYS A 1 389 ? 36.933 -20.058 12.044 1.00 25.88 ? 417 LYS A C 1 ATOM 2980 O O . LYS A 1 389 ? 37.837 -20.227 12.867 1.00 25.72 ? 417 LYS A O 1 ATOM 2981 C CB . LYS A 1 389 ? 38.070 -18.273 10.644 1.00 25.85 ? 417 LYS A CB 1 ATOM 2982 C CG . LYS A 1 389 ? 38.602 -17.976 9.240 1.00 26.19 ? 417 LYS A CG 1 ATOM 2983 C CD . LYS A 1 389 ? 39.293 -16.648 9.138 1.00 27.58 ? 417 LYS A CD 1 ATOM 2984 C CE . LYS A 1 389 ? 40.501 -16.579 10.051 1.00 26.92 ? 417 LYS A CE 1 ATOM 2985 N NZ . LYS A 1 389 ? 40.720 -15.173 10.359 1.00 24.70 ? 417 LYS A NZ 1 ATOM 2986 N N . GLY A 1 390 ? 35.655 -20.316 12.293 1.00 25.69 ? 418 GLY A N 1 ATOM 2987 C CA . GLY A 1 390 ? 35.226 -20.929 13.536 1.00 25.82 ? 418 GLY A CA 1 ATOM 2988 C C . GLY A 1 390 ? 34.738 -22.346 13.279 1.00 26.55 ? 418 GLY A C 1 ATOM 2989 O O . GLY A 1 390 ? 34.108 -22.964 14.149 1.00 26.54 ? 418 GLY A O 1 ATOM 2990 N N . LEU A 1 391 ? 35.046 -22.872 12.092 1.00 26.68 ? 419 LEU A N 1 ATOM 2991 C CA . LEU A 1 391 ? 34.480 -24.141 11.654 1.00 27.17 ? 419 LEU A CA 1 ATOM 2992 C C . LEU A 1 391 ? 34.813 -25.320 12.543 1.00 27.37 ? 419 LEU A C 1 ATOM 2993 O O . LEU A 1 391 ? 34.068 -26.288 12.570 1.00 27.67 ? 419 LEU A O 1 ATOM 2994 C CB . LEU A 1 391 ? 34.920 -24.455 10.239 1.00 27.48 ? 419 LEU A CB 1 ATOM 2995 C CG . LEU A 1 391 ? 33.817 -25.059 9.392 1.00 28.37 ? 419 LEU A CG 1 ATOM 2996 C CD1 . LEU A 1 391 ? 32.614 -24.090 9.307 1.00 27.87 ? 419 LEU A CD1 1 ATOM 2997 C CD2 . LEU A 1 391 ? 34.425 -25.273 8.046 1.00 29.80 ? 419 LEU A CD2 1 ATOM 2998 N N . ASN A 1 392 ? 35.928 -25.236 13.258 1.00 27.68 ? 420 ASN A N 1 ATOM 2999 C CA . ASN A 1 392 ? 36.379 -26.303 14.144 1.00 28.22 ? 420 ASN A CA 1 ATOM 3000 C C . ASN A 1 392 ? 35.420 -26.627 15.297 1.00 28.95 ? 420 ASN A C 1 ATOM 3001 O O . ASN A 1 392 ? 35.531 -27.673 15.936 1.00 29.19 ? 420 ASN A O 1 ATOM 3002 C CB . ASN A 1 392 ? 37.762 -25.962 14.696 1.00 27.99 ? 420 ASN A CB 1 ATOM 3003 C CG . ASN A 1 392 ? 37.746 -24.753 15.589 1.00 27.50 ? 420 ASN A CG 1 ATOM 3004 O OD1 . ASN A 1 392 ? 38.210 -24.811 16.730 1.00 25.23 ? 420 ASN A OD1 1 ATOM 3005 N ND2 . ASN A 1 392 ? 37.211 -23.642 15.082 1.00 26.97 ? 420 ASN A ND2 1 ATOM 3006 N N . GLN A 1 393 ? 34.479 -25.720 15.551 1.00 29.57 ? 421 GLN A N 1 ATOM 3007 C CA . GLN A 1 393 ? 33.433 -25.926 16.540 1.00 29.37 ? 421 GLN A CA 1 ATOM 3008 C C . GLN A 1 393 ? 32.514 -27.092 16.169 1.00 28.80 ? 421 GLN A C 1 ATOM 3009 O O . GLN A 1 393 ? 31.960 -27.760 17.051 1.00 28.64 ? 421 GLN A O 1 ATOM 3010 C CB . GLN A 1 393 ? 32.618 -24.649 16.710 1.00 29.52 ? 421 GLN A CB 1 ATOM 3011 C CG . GLN A 1 393 ? 31.614 -24.710 17.868 1.00 31.63 ? 421 GLN A CG 1 ATOM 3012 C CD . GLN A 1 393 ? 30.735 -23.453 17.981 1.00 32.41 ? 421 GLN A CD 1 ATOM 3013 O OE1 . GLN A 1 393 ? 31.047 -22.409 17.406 1.00 32.32 ? 421 GLN A OE1 1 ATOM 3014 N NE2 . GLN A 1 393 ? 29.629 -23.567 18.717 1.00 31.09 ? 421 GLN A NE2 1 ATOM 3015 N N . TYR A 1 394 ? 32.360 -27.350 14.876 1.00 27.91 ? 422 TYR A N 1 ATOM 3016 C CA . TYR A 1 394 ? 31.480 -28.444 14.444 1.00 27.84 ? 422 TYR A CA 1 ATOM 3017 C C . TYR A 1 394 ? 32.150 -29.480 13.546 1.00 27.31 ? 422 TYR A C 1 ATOM 3018 O O . TYR A 1 394 ? 31.525 -30.470 13.160 1.00 26.77 ? 422 TYR A O 1 ATOM 3019 C CB . TYR A 1 394 ? 30.236 -27.889 13.735 1.00 28.20 ? 422 TYR A CB 1 ATOM 3020 C CG . TYR A 1 394 ? 29.422 -26.924 14.567 1.00 28.95 ? 422 TYR A CG 1 ATOM 3021 C CD1 . TYR A 1 394 ? 28.587 -27.380 15.603 1.00 29.88 ? 422 TYR A CD1 1 ATOM 3022 C CD2 . TYR A 1 394 ? 29.475 -25.554 14.314 1.00 30.08 ? 422 TYR A CD2 1 ATOM 3023 C CE1 . TYR A 1 394 ? 27.825 -26.486 16.366 1.00 29.81 ? 422 TYR A CE1 1 ATOM 3024 C CE2 . TYR A 1 394 ? 28.722 -24.655 15.065 1.00 31.78 ? 422 TYR A CE2 1 ATOM 3025 C CZ . TYR A 1 394 ? 27.899 -25.130 16.088 1.00 31.32 ? 422 TYR A CZ 1 ATOM 3026 O OH . TYR A 1 394 ? 27.167 -24.230 16.825 1.00 32.19 ? 422 TYR A OH 1 ATOM 3027 N N . VAL A 1 395 ? 33.419 -29.239 13.224 1.00 27.04 ? 423 VAL A N 1 ATOM 3028 C CA . VAL A 1 395 ? 34.182 -30.047 12.282 1.00 26.80 ? 423 VAL A CA 1 ATOM 3029 C C . VAL A 1 395 ? 35.491 -30.429 12.957 1.00 27.03 ? 423 VAL A C 1 ATOM 3030 O O . VAL A 1 395 ? 36.132 -29.597 13.590 1.00 27.61 ? 423 VAL A O 1 ATOM 3031 C CB . VAL A 1 395 ? 34.460 -29.251 10.960 1.00 26.90 ? 423 VAL A CB 1 ATOM 3032 C CG1 . VAL A 1 395 ? 35.458 -29.977 10.047 1.00 26.69 ? 423 VAL A CG1 1 ATOM 3033 C CG2 . VAL A 1 395 ? 33.155 -28.965 10.205 1.00 26.34 ? 423 VAL A CG2 1 ATOM 3034 N N . ASP A 1 396 ? 35.888 -31.689 12.839 1.00 27.09 ? 424 ASP A N 1 ATOM 3035 C CA . ASP A 1 396 ? 37.163 -32.125 13.400 1.00 27.31 ? 424 ASP A CA 1 ATOM 3036 C C . ASP A 1 396 ? 37.998 -32.946 12.409 1.00 26.76 ? 424 ASP A C 1 ATOM 3037 O O . ASP A 1 396 ? 38.980 -33.563 12.778 1.00 26.69 ? 424 ASP A O 1 ATOM 3038 C CB . ASP A 1 396 ? 36.948 -32.872 14.729 1.00 27.50 ? 424 ASP A CB 1 ATOM 3039 C CG . ASP A 1 396 ? 36.319 -34.262 14.543 1.00 29.98 ? 424 ASP A CG 1 ATOM 3040 O OD1 . ASP A 1 396 ? 35.747 -34.551 13.458 1.00 31.32 ? 424 ASP A OD1 1 ATOM 3041 O OD2 . ASP A 1 396 ? 36.397 -35.084 15.493 1.00 32.24 ? 424 ASP A OD2 1 ATOM 3042 N N . PHE A 1 397 ? 37.605 -32.912 11.145 1.00 26.61 ? 425 PHE A N 1 ATOM 3043 C CA . PHE A 1 397 ? 38.222 -33.710 10.098 1.00 26.45 ? 425 PHE A CA 1 ATOM 3044 C C . PHE A 1 397 ? 38.113 -32.846 8.824 1.00 26.36 ? 425 PHE A C 1 ATOM 3045 O O . PHE A 1 397 ? 37.005 -32.523 8.388 1.00 26.55 ? 425 PHE A O 1 ATOM 3046 C CB . PHE A 1 397 ? 37.442 -35.020 9.961 1.00 26.06 ? 425 PHE A CB 1 ATOM 3047 C CG . PHE A 1 397 ? 38.152 -36.122 9.204 1.00 26.78 ? 425 PHE A CG 1 ATOM 3048 C CD1 . PHE A 1 397 ? 38.393 -36.026 7.832 1.00 25.80 ? 425 PHE A CD1 1 ATOM 3049 C CD2 . PHE A 1 397 ? 38.523 -37.300 9.862 1.00 28.54 ? 425 PHE A CD2 1 ATOM 3050 C CE1 . PHE A 1 397 ? 39.023 -37.064 7.126 1.00 26.25 ? 425 PHE A CE1 1 ATOM 3051 C CE2 . PHE A 1 397 ? 39.160 -38.351 9.167 1.00 28.42 ? 425 PHE A CE2 1 ATOM 3052 C CZ . PHE A 1 397 ? 39.401 -38.225 7.780 1.00 27.22 ? 425 PHE A CZ 1 ATOM 3053 N N . PHE A 1 398 ? 39.250 -32.438 8.250 1.00 25.20 ? 426 PHE A N 1 ATOM 3054 C CA . PHE A 1 398 ? 39.211 -31.592 7.077 1.00 23.94 ? 426 PHE A CA 1 ATOM 3055 C C . PHE A 1 398 ? 40.083 -32.141 5.950 1.00 23.86 ? 426 PHE A C 1 ATOM 3056 O O . PHE A 1 398 ? 41.263 -32.426 6.171 1.00 24.29 ? 426 PHE A O 1 ATOM 3057 C CB . PHE A 1 398 ? 39.643 -30.179 7.449 1.00 23.52 ? 426 PHE A CB 1 ATOM 3058 C CG . PHE A 1 398 ? 39.537 -29.215 6.314 1.00 22.19 ? 426 PHE A CG 1 ATOM 3059 C CD1 . PHE A 1 398 ? 38.292 -28.723 5.924 1.00 19.14 ? 426 PHE A CD1 1 ATOM 3060 C CD2 . PHE A 1 398 ? 40.672 -28.825 5.608 1.00 19.96 ? 426 PHE A CD2 1 ATOM 3061 C CE1 . PHE A 1 398 ? 38.187 -27.848 4.875 1.00 17.74 ? 426 PHE A CE1 1 ATOM 3062 C CE2 . PHE A 1 398 ? 40.569 -27.948 4.547 1.00 18.09 ? 426 PHE A CE2 1 ATOM 3063 C CZ . PHE A 1 398 ? 39.327 -27.463 4.179 1.00 17.04 ? 426 PHE A CZ 1 ATOM 3064 N N . THR A 1 399 ? 39.509 -32.298 4.756 1.00 22.84 ? 427 THR A N 1 ATOM 3065 C CA . THR A 1 399 ? 40.275 -32.759 3.589 1.00 22.37 ? 427 THR A CA 1 ATOM 3066 C C . THR A 1 399 ? 39.858 -32.055 2.310 1.00 22.25 ? 427 THR A C 1 ATOM 3067 O O . THR A 1 399 ? 38.676 -31.773 2.118 1.00 22.47 ? 427 THR A O 1 ATOM 3068 C CB . THR A 1 399 ? 40.070 -34.243 3.299 1.00 22.36 ? 427 THR A CB 1 ATOM 3069 O OG1 . THR A 1 399 ? 38.701 -34.466 2.988 1.00 21.17 ? 427 THR A OG1 1 ATOM 3070 C CG2 . THR A 1 399 ? 40.477 -35.122 4.476 1.00 23.29 ? 427 THR A CG2 1 ATOM 3071 N N . VAL A 1 400 ? 40.817 -31.773 1.434 1.00 21.48 ? 428 VAL A N 1 ATOM 3072 C CA . VAL A 1 400 ? 40.482 -31.201 0.147 1.00 20.85 ? 428 VAL A CA 1 ATOM 3073 C C . VAL A 1 400 ? 40.596 -32.258 -0.930 1.00 20.80 ? 428 VAL A C 1 ATOM 3074 O O . VAL A 1 400 ? 41.419 -33.174 -0.846 1.00 21.46 ? 428 VAL A O 1 ATOM 3075 C CB . VAL A 1 400 ? 41.327 -29.958 -0.195 1.00 21.12 ? 428 VAL A CB 1 ATOM 3076 C CG1 . VAL A 1 400 ? 41.149 -28.870 0.859 1.00 20.67 ? 428 VAL A CG1 1 ATOM 3077 C CG2 . VAL A 1 400 ? 42.797 -30.282 -0.343 1.00 21.49 ? 428 VAL A CG2 1 ATOM 3078 N N . ASN A 1 401 ? 39.709 -32.165 -1.906 1.00 20.38 ? 429 ASN A N 1 ATOM 3079 C CA . ASN A 1 401 ? 39.798 -32.940 -3.134 1.00 20.04 ? 429 ASN A CA 1 ATOM 3080 C C . ASN A 1 401 ? 40.637 -32.135 -4.156 1.00 19.83 ? 429 ASN A C 1 ATOM 3081 O O . ASN A 1 401 ? 40.240 -31.025 -4.554 1.00 19.20 ? 429 ASN A O 1 ATOM 3082 C CB . ASN A 1 401 ? 38.381 -33.216 -3.657 1.00 19.71 ? 429 ASN A CB 1 ATOM 3083 C CG . ASN A 1 401 ? 38.328 -34.339 -4.691 1.00 21.91 ? 429 ASN A CG 1 ATOM 3084 O OD1 . ASN A 1 401 ? 39.245 -35.166 -4.778 1.00 21.73 ? 429 ASN A OD1 1 ATOM 3085 N ND2 . ASN A 1 401 ? 37.233 -34.380 -5.481 1.00 21.80 ? 429 ASN A ND2 1 ATOM 3086 N N . PRO A 1 402 ? 41.809 -32.677 -4.572 1.00 19.50 ? 430 PRO A N 1 ATOM 3087 C CA . PRO A 1 402 ? 42.757 -31.960 -5.402 1.00 19.07 ? 430 PRO A CA 1 ATOM 3088 C C . PRO A 1 402 ? 42.440 -32.144 -6.891 1.00 19.02 ? 430 PRO A C 1 ATOM 3089 O O . PRO A 1 402 ? 41.481 -32.842 -7.221 1.00 19.29 ? 430 PRO A O 1 ATOM 3090 C CB . PRO A 1 402 ? 44.060 -32.655 -5.056 1.00 18.83 ? 430 PRO A CB 1 ATOM 3091 C CG . PRO A 1 402 ? 43.682 -34.037 -4.935 1.00 18.61 ? 430 PRO A CG 1 ATOM 3092 C CD . PRO A 1 402 ? 42.274 -34.055 -4.355 1.00 19.74 ? 430 PRO A CD 1 ATOM 3093 N N . MET A 1 403 ? 43.237 -31.535 -7.770 1.00 18.75 ? 431 MET A N 1 ATOM 3094 C CA . MET A 1 403 ? 43.101 -31.722 -9.214 1.00 19.19 ? 431 MET A CA 1 ATOM 3095 C C . MET A 1 403 ? 43.787 -33.003 -9.642 1.00 20.16 ? 431 MET A C 1 ATOM 3096 O O . MET A 1 403 ? 44.576 -33.547 -8.888 1.00 20.35 ? 431 MET A O 1 ATOM 3097 C CB . MET A 1 403 ? 43.763 -30.575 -9.959 1.00 18.74 ? 431 MET A CB 1 ATOM 3098 C CG . MET A 1 403 ? 43.226 -29.236 -9.635 1.00 17.67 ? 431 MET A CG 1 ATOM 3099 S SD . MET A 1 403 ? 44.023 -28.004 -10.657 1.00 17.84 ? 431 MET A SD 1 ATOM 3100 C CE . MET A 1 403 ? 45.423 -27.567 -9.643 1.00 15.43 ? 431 MET A CE 1 ATOM 3101 N N . GLU A 1 404 ? 43.531 -33.466 -10.867 1.00 21.48 ? 432 GLU A N 1 ATOM 3102 C CA . GLU A 1 404 ? 44.288 -34.584 -11.411 1.00 22.54 ? 432 GLU A CA 1 ATOM 3103 C C . GLU A 1 404 ? 45.759 -34.193 -11.655 1.00 23.01 ? 432 GLU A C 1 ATOM 3104 O O . GLU A 1 404 ? 46.594 -35.080 -11.891 1.00 24.23 ? 432 GLU A O 1 ATOM 3105 C CB . GLU A 1 404 ? 43.643 -35.155 -12.669 1.00 22.96 ? 432 GLU A CB 1 ATOM 3106 C CG . GLU A 1 404 ? 43.487 -34.176 -13.846 1.00 26.55 ? 432 GLU A CG 1 ATOM 3107 C CD . GLU A 1 404 ? 43.092 -34.888 -15.147 1.00 31.63 ? 432 GLU A CD 1 ATOM 3108 O OE1 . GLU A 1 404 ? 43.991 -35.439 -15.825 1.00 34.66 ? 432 GLU A OE1 1 ATOM 3109 O OE2 . GLU A 1 404 ? 41.880 -34.921 -15.487 1.00 33.94 ? 432 GLU A OE2 1 ATOM 3110 N N . HIS A 1 405 ? 46.054 -32.881 -11.578 1.00 22.57 ? 433 HIS A N 1 ATOM 3111 C CA . HIS A 1 405 ? 47.404 -32.281 -11.637 1.00 21.35 ? 433 HIS A CA 1 ATOM 3112 C C . HIS A 1 405 ? 48.014 -32.153 -10.244 1.00 21.34 ? 433 HIS A C 1 ATOM 3113 O O . HIS A 1 405 ? 47.715 -31.197 -9.501 1.00 21.28 ? 433 HIS A O 1 ATOM 3114 C CB . HIS A 1 405 ? 47.324 -30.891 -12.251 1.00 21.18 ? 433 HIS A CB 1 ATOM 3115 C CG . HIS A 1 405 ? 46.539 -30.846 -13.522 1.00 21.53 ? 433 HIS A CG 1 ATOM 3116 N ND1 . HIS A 1 405 ? 46.923 -31.529 -14.658 1.00 22.45 ? 433 HIS A ND1 1 ATOM 3117 C CD2 . HIS A 1 405 ? 45.385 -30.217 -13.833 1.00 19.73 ? 433 HIS A CD2 1 ATOM 3118 C CE1 . HIS A 1 405 ? 46.038 -31.318 -15.615 1.00 21.09 ? 433 HIS A CE1 1 ATOM 3119 N NE2 . HIS A 1 405 ? 45.098 -30.523 -15.139 1.00 19.04 ? 433 HIS A NE2 1 ATOM 3120 N N . ALA A 1 406 ? 48.885 -33.102 -9.895 1.00 20.38 ? 434 ALA A N 1 ATOM 3121 C CA . ALA A 1 406 ? 49.369 -33.201 -8.539 1.00 19.28 ? 434 ALA A CA 1 ATOM 3122 C C . ALA A 1 406 ? 50.241 -32.016 -8.200 1.00 19.33 ? 434 ALA A C 1 ATOM 3123 O O . ALA A 1 406 ? 50.117 -31.429 -7.105 1.00 19.44 ? 434 ALA A O 1 ATOM 3124 C CB . ALA A 1 406 ? 50.103 -34.492 -8.326 1.00 18.99 ? 434 ALA A CB 1 ATOM 3125 N N . GLU A 1 407 ? 51.085 -31.618 -9.147 1.00 19.30 ? 435 GLU A N 1 ATOM 3126 C CA . GLU A 1 407 ? 52.065 -30.578 -8.845 1.00 19.34 ? 435 GLU A CA 1 ATOM 3127 C C . GLU A 1 407 ? 51.419 -29.224 -8.467 1.00 19.42 ? 435 GLU A C 1 ATOM 3128 O O . GLU A 1 407 ? 51.731 -28.644 -7.423 1.00 18.98 ? 435 GLU A O 1 ATOM 3129 C CB . GLU A 1 407 ? 53.126 -30.449 -9.934 1.00 18.80 ? 435 GLU A CB 1 ATOM 3130 C CG . GLU A 1 407 ? 54.327 -29.552 -9.531 1.00 19.86 ? 435 GLU A CG 1 ATOM 3131 C CD . GLU A 1 407 ? 55.157 -30.086 -8.354 1.00 24.51 ? 435 GLU A CD 1 ATOM 3132 O OE1 . GLU A 1 407 ? 55.053 -31.288 -8.006 1.00 26.37 ? 435 GLU A OE1 1 ATOM 3133 O OE2 . GLU A 1 407 ? 55.936 -29.295 -7.769 1.00 27.05 ? 435 GLU A OE2 1 ATOM 3134 N N . LEU A 1 408 ? 50.500 -28.749 -9.299 1.00 19.52 ? 436 LEU A N 1 ATOM 3135 C CA . LEU A 1 408 ? 49.919 -27.445 -9.089 1.00 18.99 ? 436 LEU A CA 1 ATOM 3136 C C . LEU A 1 408 ? 48.853 -27.478 -8.004 1.00 18.87 ? 436 LEU A C 1 ATOM 3137 O O . LEU A 1 408 ? 48.421 -26.431 -7.540 1.00 18.87 ? 436 LEU A O 1 ATOM 3138 C CB . LEU A 1 408 ? 49.362 -26.890 -10.403 1.00 18.72 ? 436 LEU A CB 1 ATOM 3139 C CG . LEU A 1 408 ? 50.401 -26.460 -11.445 1.00 20.11 ? 436 LEU A CG 1 ATOM 3140 C CD1 . LEU A 1 408 ? 49.753 -25.758 -12.585 1.00 20.23 ? 436 LEU A CD1 1 ATOM 3141 C CD2 . LEU A 1 408 ? 51.459 -25.563 -10.906 1.00 20.75 ? 436 LEU A CD2 1 ATOM 3142 N N . SER A 1 409 ? 48.410 -28.674 -7.617 1.00 18.51 ? 437 SER A N 1 ATOM 3143 C CA . SER A 1 409 ? 47.502 -28.800 -6.496 1.00 17.94 ? 437 SER A CA 1 ATOM 3144 C C . SER A 1 409 ? 48.235 -28.351 -5.231 1.00 18.28 ? 437 SER A C 1 ATOM 3145 O O . SER A 1 409 ? 47.628 -27.919 -4.256 1.00 18.75 ? 437 SER A O 1 ATOM 3146 C CB . SER A 1 409 ? 47.016 -30.247 -6.336 1.00 17.98 ? 437 SER A CB 1 ATOM 3147 O OG . SER A 1 409 ? 45.982 -30.568 -7.243 1.00 16.55 ? 437 SER A OG 1 ATOM 3148 N N . LYS A 1 410 ? 49.555 -28.448 -5.245 1.00 18.41 ? 438 LYS A N 1 ATOM 3149 C CA . LYS A 1 410 ? 50.332 -28.082 -4.071 1.00 18.11 ? 438 LYS A CA 1 ATOM 3150 C C . LYS A 1 410 ? 50.039 -26.659 -3.587 1.00 18.76 ? 438 LYS A C 1 ATOM 3151 O O . LYS A 1 410 ? 50.122 -26.387 -2.375 1.00 19.10 ? 438 LYS A O 1 ATOM 3152 C CB . LYS A 1 410 ? 51.830 -28.292 -4.306 1.00 17.22 ? 438 LYS A CB 1 ATOM 3153 C CG . LYS A 1 410 ? 52.226 -29.728 -4.427 1.00 15.94 ? 438 LYS A CG 1 ATOM 3154 C CD . LYS A 1 410 ? 53.733 -29.868 -4.533 1.00 15.58 ? 438 LYS A CD 1 ATOM 3155 C CE . LYS A 1 410 ? 54.154 -31.320 -4.711 1.00 17.05 ? 438 LYS A CE 1 ATOM 3156 N NZ . LYS A 1 410 ? 55.552 -31.480 -5.284 1.00 18.13 ? 438 LYS A NZ 1 ATOM 3157 N N . ILE A 1 411 ? 49.696 -25.744 -4.502 1.00 18.82 ? 439 ILE A N 1 ATOM 3158 C CA . ILE A 1 411 ? 49.490 -24.355 -4.079 1.00 19.06 ? 439 ILE A CA 1 ATOM 3159 C C . ILE A 1 411 ? 48.291 -24.297 -3.138 1.00 19.52 ? 439 ILE A C 1 ATOM 3160 O O . ILE A 1 411 ? 48.369 -23.747 -2.052 1.00 19.25 ? 439 ILE A O 1 ATOM 3161 C CB . ILE A 1 411 ? 49.314 -23.391 -5.251 1.00 18.75 ? 439 ILE A CB 1 ATOM 3162 C CG1 . ILE A 1 411 ? 50.626 -23.265 -6.027 1.00 19.37 ? 439 ILE A CG1 1 ATOM 3163 C CG2 . ILE A 1 411 ? 48.900 -22.006 -4.745 1.00 18.77 ? 439 ILE A CG2 1 ATOM 3164 C CD1 . ILE A 1 411 ? 50.523 -22.483 -7.334 1.00 17.87 ? 439 ILE A CD1 1 ATOM 3165 N N . SER A 1 412 ? 47.203 -24.931 -3.542 1.00 19.89 ? 440 SER A N 1 ATOM 3166 C CA . SER A 1 412 ? 45.986 -24.878 -2.774 1.00 20.48 ? 440 SER A CA 1 ATOM 3167 C C . SER A 1 412 ? 46.080 -25.663 -1.467 1.00 20.25 ? 440 SER A C 1 ATOM 3168 O O . SER A 1 412 ? 45.562 -25.224 -0.431 1.00 20.48 ? 440 SER A O 1 ATOM 3169 C CB . SER A 1 412 ? 44.835 -25.397 -3.615 1.00 20.83 ? 440 SER A CB 1 ATOM 3170 O OG . SER A 1 412 ? 43.671 -24.742 -3.205 1.00 23.22 ? 440 SER A OG 1 ATOM 3171 N N . ILE A 1 413 ? 46.747 -26.817 -1.529 1.00 19.64 ? 441 ILE A N 1 ATOM 3172 C CA . ILE A 1 413 ? 46.942 -27.696 -0.380 1.00 18.96 ? 441 ILE A CA 1 ATOM 3173 C C . ILE A 1 413 ? 47.785 -26.994 0.681 1.00 19.07 ? 441 ILE A C 1 ATOM 3174 O O . ILE A 1 413 ? 47.475 -27.072 1.875 1.00 19.37 ? 441 ILE A O 1 ATOM 3175 C CB . ILE A 1 413 ? 47.578 -29.051 -0.811 1.00 19.30 ? 441 ILE A CB 1 ATOM 3176 C CG1 . ILE A 1 413 ? 46.563 -29.900 -1.593 1.00 17.97 ? 441 ILE A CG1 1 ATOM 3177 C CG2 . ILE A 1 413 ? 48.066 -29.843 0.391 1.00 19.55 ? 441 ILE A CG2 1 ATOM 3178 C CD1 . ILE A 1 413 ? 47.181 -30.941 -2.467 1.00 15.92 ? 441 ILE A CD1 1 ATOM 3179 N N . HIS A 1 414 ? 48.837 -26.299 0.240 1.00 18.47 ? 442 HIS A N 1 ATOM 3180 C CA . HIS A 1 414 ? 49.674 -25.488 1.128 1.00 18.05 ? 442 HIS A CA 1 ATOM 3181 C C . HIS A 1 414 ? 48.786 -24.641 2.040 1.00 18.25 ? 442 HIS A C 1 ATOM 3182 O O . HIS A 1 414 ? 48.962 -24.644 3.274 1.00 18.29 ? 442 HIS A O 1 ATOM 3183 C CB . HIS A 1 414 ? 50.609 -24.594 0.320 1.00 17.48 ? 442 HIS A CB 1 ATOM 3184 C CG . HIS A 1 414 ? 51.783 -24.065 1.086 1.00 17.54 ? 442 HIS A CG 1 ATOM 3185 N ND1 . HIS A 1 414 ? 51.723 -22.922 1.859 1.00 17.67 ? 442 HIS A ND1 1 ATOM 3186 C CD2 . HIS A 1 414 ? 53.064 -24.499 1.159 1.00 17.57 ? 442 HIS A CD2 1 ATOM 3187 C CE1 . HIS A 1 414 ? 52.912 -22.687 2.388 1.00 17.69 ? 442 HIS A CE1 1 ATOM 3188 N NE2 . HIS A 1 414 ? 53.742 -23.636 1.990 1.00 17.63 ? 442 HIS A NE2 1 ATOM 3189 N N . THR A 1 415 ? 47.821 -23.945 1.439 1.00 17.85 ? 443 THR A N 1 ATOM 3190 C CA . THR A 1 415 ? 46.933 -23.081 2.217 1.00 17.90 ? 443 THR A CA 1 ATOM 3191 C C . THR A 1 415 ? 45.954 -23.902 3.095 1.00 18.25 ? 443 THR A C 1 ATOM 3192 O O . THR A 1 415 ? 45.540 -23.428 4.150 1.00 18.05 ? 443 THR A O 1 ATOM 3193 C CB . THR A 1 415 ? 46.153 -22.057 1.328 1.00 17.76 ? 443 THR A CB 1 ATOM 3194 O OG1 . THR A 1 415 ? 45.043 -22.702 0.676 1.00 17.38 ? 443 THR A OG1 1 ATOM 3195 C CG2 . THR A 1 415 ? 47.071 -21.401 0.298 1.00 15.88 ? 443 THR A CG2 1 ATOM 3196 N N . ALA A 1 416 ? 45.589 -25.111 2.646 1.00 18.18 ? 444 ALA A N 1 ATOM 3197 C CA . ALA A 1 416 ? 44.748 -25.999 3.438 1.00 18.35 ? 444 ALA A CA 1 ATOM 3198 C C . ALA A 1 416 ? 45.483 -26.480 4.676 1.00 18.52 ? 444 ALA A C 1 ATOM 3199 O O . ALA A 1 416 ? 44.855 -26.688 5.710 1.00 19.01 ? 444 ALA A O 1 ATOM 3200 C CB . ALA A 1 416 ? 44.276 -27.180 2.635 1.00 17.95 ? 444 ALA A CB 1 ATOM 3201 N N . ALA A 1 417 ? 46.801 -26.658 4.576 1.00 18.57 ? 445 ALA A N 1 ATOM 3202 C CA . ALA A 1 417 ? 47.614 -27.018 5.744 1.00 18.28 ? 445 ALA A CA 1 ATOM 3203 C C . ALA A 1 417 ? 47.532 -25.927 6.792 1.00 18.68 ? 445 ALA A C 1 ATOM 3204 O O . ALA A 1 417 ? 47.399 -26.225 7.983 1.00 18.76 ? 445 ALA A O 1 ATOM 3205 C CB . ALA A 1 417 ? 49.026 -27.243 5.360 1.00 17.81 ? 445 ALA A CB 1 ATOM 3206 N N . ASP A 1 418 ? 47.581 -24.666 6.349 1.00 18.94 ? 446 ASP A N 1 ATOM 3207 C CA . ASP A 1 418 ? 47.614 -23.543 7.273 1.00 19.08 ? 446 ASP A CA 1 ATOM 3208 C C . ASP A 1 418 ? 46.265 -23.374 7.933 1.00 19.09 ? 446 ASP A C 1 ATOM 3209 O O . ASP A 1 418 ? 46.194 -23.115 9.138 1.00 19.33 ? 446 ASP A O 1 ATOM 3210 C CB . ASP A 1 418 ? 48.026 -22.246 6.567 1.00 19.67 ? 446 ASP A CB 1 ATOM 3211 C CG . ASP A 1 418 ? 48.284 -21.088 7.546 1.00 20.76 ? 446 ASP A CG 1 ATOM 3212 O OD1 . ASP A 1 418 ? 48.924 -21.298 8.585 1.00 23.73 ? 446 ASP A OD1 1 ATOM 3213 O OD2 . ASP A 1 418 ? 47.863 -19.955 7.274 1.00 22.42 ? 446 ASP A OD2 1 ATOM 3214 N N . TYR A 1 419 ? 45.207 -23.538 7.143 1.00 18.70 ? 447 TYR A N 1 ATOM 3215 C CA . TYR A 1 419 ? 43.855 -23.240 7.590 1.00 18.83 ? 447 TYR A CA 1 ATOM 3216 C C . TYR A 1 419 ? 43.386 -24.274 8.598 1.00 19.29 ? 447 TYR A C 1 ATOM 3217 O O . TYR A 1 419 ? 42.676 -23.944 9.528 1.00 19.55 ? 447 TYR A O 1 ATOM 3218 C CB . TYR A 1 419 ? 42.873 -23.163 6.411 1.00 18.54 ? 447 TYR A CB 1 ATOM 3219 C CG . TYR A 1 419 ? 41.408 -23.280 6.807 1.00 18.82 ? 447 TYR A CG 1 ATOM 3220 C CD1 . TYR A 1 419 ? 40.677 -22.156 7.236 1.00 19.27 ? 447 TYR A CD1 1 ATOM 3221 C CD2 . TYR A 1 419 ? 40.750 -24.514 6.770 1.00 17.79 ? 447 TYR A CD2 1 ATOM 3222 C CE1 . TYR A 1 419 ? 39.317 -22.269 7.622 1.00 18.21 ? 447 TYR A CE1 1 ATOM 3223 C CE2 . TYR A 1 419 ? 39.396 -24.642 7.157 1.00 17.49 ? 447 TYR A CE2 1 ATOM 3224 C CZ . TYR A 1 419 ? 38.693 -23.515 7.580 1.00 17.51 ? 447 TYR A CZ 1 ATOM 3225 O OH . TYR A 1 419 ? 37.377 -23.641 7.932 1.00 16.21 ? 447 TYR A OH 1 ATOM 3226 N N . SER A 1 420 ? 43.780 -25.524 8.418 1.00 19.52 ? 448 SER A N 1 ATOM 3227 C CA . SER A 1 420 ? 43.302 -26.563 9.303 1.00 19.59 ? 448 SER A CA 1 ATOM 3228 C C . SER A 1 420 ? 44.209 -26.714 10.527 1.00 20.18 ? 448 SER A C 1 ATOM 3229 O O . SER A 1 420 ? 43.779 -27.228 11.563 1.00 20.85 ? 448 SER A O 1 ATOM 3230 C CB . SER A 1 420 ? 43.168 -27.878 8.553 1.00 19.05 ? 448 SER A CB 1 ATOM 3231 O OG . SER A 1 420 ? 44.402 -28.191 7.959 1.00 18.67 ? 448 SER A OG 1 ATOM 3232 N N . TRP A 1 421 ? 45.446 -26.251 10.430 1.00 20.26 ? 449 TRP A N 1 ATOM 3233 C CA . TRP A 1 421 ? 46.333 -26.308 11.584 1.00 20.73 ? 449 TRP A CA 1 ATOM 3234 C C . TRP A 1 421 ? 46.095 -25.129 12.548 1.00 21.46 ? 449 TRP A C 1 ATOM 3235 O O . TRP A 1 421 ? 45.946 -25.330 13.760 1.00 22.00 ? 449 TRP A O 1 ATOM 3236 C CB . TRP A 1 421 ? 47.794 -26.403 11.147 1.00 20.33 ? 449 TRP A CB 1 ATOM 3237 C CG . TRP A 1 421 ? 48.758 -26.485 12.271 1.00 19.73 ? 449 TRP A CG 1 ATOM 3238 C CD1 . TRP A 1 421 ? 49.270 -25.442 12.983 1.00 19.72 ? 449 TRP A CD1 1 ATOM 3239 C CD2 . TRP A 1 421 ? 49.356 -27.673 12.805 1.00 18.89 ? 449 TRP A CD2 1 ATOM 3240 N NE1 . TRP A 1 421 ? 50.145 -25.910 13.940 1.00 20.56 ? 449 TRP A NE1 1 ATOM 3241 C CE2 . TRP A 1 421 ? 50.217 -27.273 13.852 1.00 18.45 ? 449 TRP A CE2 1 ATOM 3242 C CE3 . TRP A 1 421 ? 49.233 -29.044 12.512 1.00 19.61 ? 449 TRP A CE3 1 ATOM 3243 C CZ2 . TRP A 1 421 ? 50.963 -28.187 14.605 1.00 18.99 ? 449 TRP A CZ2 1 ATOM 3244 C CZ3 . TRP A 1 421 ? 49.977 -29.962 13.266 1.00 18.67 ? 449 TRP A CZ3 1 ATOM 3245 C CH2 . TRP A 1 421 ? 50.825 -29.525 14.302 1.00 19.63 ? 449 TRP A CH2 1 ATOM 3246 N N . ASN A 1 422 ? 46.051 -23.910 12.012 1.00 21.43 ? 450 ASN A N 1 ATOM 3247 C CA . ASN A 1 422 ? 45.895 -22.724 12.827 1.00 21.55 ? 450 ASN A CA 1 ATOM 3248 C C . ASN A 1 422 ? 44.773 -21.887 12.224 1.00 22.32 ? 450 ASN A C 1 ATOM 3249 O O . ASN A 1 422 ? 45.012 -20.904 11.494 1.00 21.83 ? 450 ASN A O 1 ATOM 3250 C CB . ASN A 1 422 ? 47.226 -21.960 12.879 1.00 21.98 ? 450 ASN A CB 1 ATOM 3251 C CG . ASN A 1 422 ? 47.200 -20.803 13.855 1.00 21.47 ? 450 ASN A CG 1 ATOM 3252 O OD1 . ASN A 1 422 ? 46.132 -20.321 14.206 1.00 22.71 ? 450 ASN A OD1 1 ATOM 3253 N ND2 . ASN A 1 422 ? 48.376 -20.340 14.288 1.00 20.04 ? 450 ASN A ND2 1 ATOM 3254 N N . MET A 1 423 ? 43.545 -22.300 12.537 1.00 22.94 ? 451 MET A N 1 ATOM 3255 C CA . MET A 1 423 ? 42.352 -21.823 11.844 1.00 24.01 ? 451 MET A CA 1 ATOM 3256 C C . MET A 1 423 ? 41.988 -20.371 12.115 1.00 24.55 ? 451 MET A C 1 ATOM 3257 O O . MET A 1 423 ? 41.640 -19.639 11.184 1.00 24.92 ? 451 MET A O 1 ATOM 3258 C CB . MET A 1 423 ? 41.147 -22.715 12.141 1.00 23.92 ? 451 MET A CB 1 ATOM 3259 C CG . MET A 1 423 ? 40.054 -22.570 11.115 1.00 24.83 ? 451 MET A CG 1 ATOM 3260 S SD . MET A 1 423 ? 38.539 -23.451 11.522 1.00 28.22 ? 451 MET A SD 1 ATOM 3261 C CE . MET A 1 423 ? 38.921 -25.096 10.919 1.00 27.00 ? 451 MET A CE 1 ATOM 3262 N N . ASP A 1 424 ? 42.061 -19.946 13.373 1.00 24.93 ? 452 ASP A N 1 ATOM 3263 C CA . ASP A 1 424 ? 41.597 -18.599 13.713 1.00 25.28 ? 452 ASP A CA 1 ATOM 3264 C C . ASP A 1 424 ? 42.528 -17.513 13.176 1.00 24.64 ? 452 ASP A C 1 ATOM 3265 O O . ASP A 1 424 ? 42.093 -16.393 12.968 1.00 25.39 ? 452 ASP A O 1 ATOM 3266 C CB . ASP A 1 424 ? 41.310 -18.449 15.221 1.00 25.77 ? 452 ASP A CB 1 ATOM 3267 C CG . ASP A 1 424 ? 42.486 -18.844 16.095 1.00 29.16 ? 452 ASP A CG 1 ATOM 3268 O OD1 . ASP A 1 424 ? 43.539 -19.286 15.573 1.00 32.81 ? 452 ASP A OD1 1 ATOM 3269 O OD2 . ASP A 1 424 ? 42.347 -18.701 17.326 1.00 34.27 ? 452 ASP A OD2 1 ATOM 3270 N N . ASN A 1 425 ? 43.793 -17.851 12.928 1.00 23.96 ? 453 ASN A N 1 ATOM 3271 C CA . ASN A 1 425 ? 44.803 -16.900 12.432 1.00 23.13 ? 453 ASN A CA 1 ATOM 3272 C C . ASN A 1 425 ? 44.873 -16.826 10.900 1.00 22.86 ? 453 ASN A C 1 ATOM 3273 O O . ASN A 1 425 ? 45.639 -16.040 10.341 1.00 23.39 ? 453 ASN A O 1 ATOM 3274 C CB . ASN A 1 425 ? 46.175 -17.286 13.008 1.00 23.02 ? 453 ASN A CB 1 ATOM 3275 C CG . ASN A 1 425 ? 47.319 -16.433 12.468 1.00 24.10 ? 453 ASN A CG 1 ATOM 3276 O OD1 . ASN A 1 425 ? 47.557 -15.320 12.937 1.00 24.90 ? 453 ASN A OD1 1 ATOM 3277 N ND2 . ASN A 1 425 ? 48.047 -16.969 11.483 1.00 26.01 ? 453 ASN A ND2 1 ATOM 3278 N N . TYR A 1 426 ? 44.079 -17.640 10.221 1.00 22.52 ? 454 TYR A N 1 ATOM 3279 C CA . TYR A 1 426 ? 44.209 -17.832 8.781 1.00 22.71 ? 454 TYR A CA 1 ATOM 3280 C C . TYR A 1 426 ? 43.794 -16.604 7.943 1.00 23.38 ? 454 TYR A C 1 ATOM 3281 O O . TYR A 1 426 ? 42.665 -16.114 8.030 1.00 22.98 ? 454 TYR A O 1 ATOM 3282 C CB . TYR A 1 426 ? 43.428 -19.084 8.357 1.00 21.93 ? 454 TYR A CB 1 ATOM 3283 C CG . TYR A 1 426 ? 43.414 -19.345 6.869 1.00 21.27 ? 454 TYR A CG 1 ATOM 3284 C CD1 . TYR A 1 426 ? 44.527 -19.892 6.218 1.00 19.97 ? 454 TYR A CD1 1 ATOM 3285 C CD2 . TYR A 1 426 ? 42.285 -19.052 6.098 1.00 19.15 ? 454 TYR A CD2 1 ATOM 3286 C CE1 . TYR A 1 426 ? 44.505 -20.149 4.833 1.00 17.54 ? 454 TYR A CE1 1 ATOM 3287 C CE2 . TYR A 1 426 ? 42.258 -19.311 4.726 1.00 17.26 ? 454 TYR A CE2 1 ATOM 3288 C CZ . TYR A 1 426 ? 43.367 -19.847 4.099 1.00 17.45 ? 454 TYR A CZ 1 ATOM 3289 O OH . TYR A 1 426 ? 43.332 -20.076 2.732 1.00 17.09 ? 454 TYR A OH 1 ATOM 3290 N N . ASP A 1 427 ? 44.731 -16.135 7.127 1.00 24.37 ? 455 ASP A N 1 ATOM 3291 C CA . ASP A 1 427 ? 44.530 -15.002 6.223 1.00 25.36 ? 455 ASP A CA 1 ATOM 3292 C C . ASP A 1 427 ? 44.782 -15.502 4.789 1.00 25.25 ? 455 ASP A C 1 ATOM 3293 O O . ASP A 1 427 ? 45.939 -15.677 4.379 1.00 24.53 ? 455 ASP A O 1 ATOM 3294 C CB . ASP A 1 427 ? 45.511 -13.889 6.610 1.00 25.85 ? 455 ASP A CB 1 ATOM 3295 C CG . ASP A 1 427 ? 45.413 -12.640 5.716 1.00 29.15 ? 455 ASP A CG 1 ATOM 3296 O OD1 . ASP A 1 427 ? 45.021 -12.704 4.514 1.00 31.84 ? 455 ASP A OD1 1 ATOM 3297 O OD2 . ASP A 1 427 ? 45.774 -11.561 6.240 1.00 33.22 ? 455 ASP A OD2 1 ATOM 3298 N N . TYR A 1 428 ? 43.705 -15.734 4.041 1.00 25.58 ? 456 TYR A N 1 ATOM 3299 C CA . TYR A 1 428 ? 43.817 -16.359 2.714 1.00 26.48 ? 456 TYR A CA 1 ATOM 3300 C C . TYR A 1 428 ? 44.785 -15.682 1.734 1.00 26.85 ? 456 TYR A C 1 ATOM 3301 O O . TYR A 1 428 ? 45.479 -16.392 1.013 1.00 26.79 ? 456 TYR A O 1 ATOM 3302 C CB . TYR A 1 428 ? 42.448 -16.597 2.060 1.00 26.55 ? 456 TYR A CB 1 ATOM 3303 C CG . TYR A 1 428 ? 41.784 -15.359 1.512 1.00 27.08 ? 456 TYR A CG 1 ATOM 3304 C CD1 . TYR A 1 428 ? 42.180 -14.823 0.287 1.00 27.65 ? 456 TYR A CD1 1 ATOM 3305 C CD2 . TYR A 1 428 ? 40.753 -14.721 2.218 1.00 27.83 ? 456 TYR A CD2 1 ATOM 3306 C CE1 . TYR A 1 428 ? 41.584 -13.662 -0.230 1.00 29.66 ? 456 TYR A CE1 1 ATOM 3307 C CE2 . TYR A 1 428 ? 40.131 -13.560 1.713 1.00 28.87 ? 456 TYR A CE2 1 ATOM 3308 C CZ . TYR A 1 428 ? 40.550 -13.037 0.479 1.00 30.19 ? 456 TYR A CZ 1 ATOM 3309 O OH . TYR A 1 428 ? 39.958 -11.907 -0.050 1.00 29.20 ? 456 TYR A OH 1 ATOM 3310 N N . ASP A 1 429 ? 44.848 -14.341 1.708 1.00 27.38 ? 457 ASP A N 1 ATOM 3311 C CA . ASP A 1 429 ? 45.830 -13.651 0.842 1.00 28.36 ? 457 ASP A CA 1 ATOM 3312 C C . ASP A 1 429 ? 47.268 -13.875 1.328 1.00 28.37 ? 457 ASP A C 1 ATOM 3313 O O . ASP A 1 429 ? 48.166 -14.083 0.512 1.00 28.45 ? 457 ASP A O 1 ATOM 3314 C CB . ASP A 1 429 ? 45.560 -12.133 0.669 1.00 28.84 ? 457 ASP A CB 1 ATOM 3315 C CG . ASP A 1 429 ? 46.132 -11.563 -0.664 1.00 32.66 ? 457 ASP A CG 1 ATOM 3316 O OD1 . ASP A 1 429 ? 45.813 -12.151 -1.735 1.00 35.88 ? 457 ASP A OD1 1 ATOM 3317 O OD2 . ASP A 1 429 ? 46.876 -10.527 -0.663 1.00 36.23 ? 457 ASP A OD2 1 ATOM 3318 N N . LYS A 1 430 ? 47.496 -13.806 2.641 1.00 28.30 ? 458 LYS A N 1 ATOM 3319 C CA . LYS A 1 430 ? 48.840 -14.018 3.166 1.00 28.56 ? 458 LYS A CA 1 ATOM 3320 C C . LYS A 1 430 ? 49.293 -15.455 2.939 1.00 27.41 ? 458 LYS A C 1 ATOM 3321 O O . LYS A 1 430 ? 50.445 -15.686 2.579 1.00 27.35 ? 458 LYS A O 1 ATOM 3322 C CB . LYS A 1 430 ? 48.934 -13.645 4.651 1.00 29.55 ? 458 LYS A CB 1 ATOM 3323 C CG . LYS A 1 430 ? 49.270 -12.175 4.872 1.00 34.03 ? 458 LYS A CG 1 ATOM 3324 C CD . LYS A 1 430 ? 49.169 -11.749 6.341 1.00 40.19 ? 458 LYS A CD 1 ATOM 3325 C CE . LYS A 1 430 ? 48.871 -10.236 6.442 1.00 43.65 ? 458 LYS A CE 1 ATOM 3326 N NZ . LYS A 1 430 ? 48.937 -9.789 7.868 1.00 45.88 ? 458 LYS A NZ 1 ATOM 3327 N N . ALA A 1 431 ? 48.368 -16.398 3.129 1.00 26.09 ? 459 ALA A N 1 ATOM 3328 C CA . ALA A 1 431 ? 48.620 -17.830 2.972 1.00 24.88 ? 459 ALA A CA 1 ATOM 3329 C C . ALA A 1 431 ? 48.865 -18.191 1.513 1.00 24.14 ? 459 ALA A C 1 ATOM 3330 O O . ALA A 1 431 ? 49.719 -19.025 1.202 1.00 24.17 ? 459 ALA A O 1 ATOM 3331 C CB . ALA A 1 431 ? 47.462 -18.637 3.533 1.00 24.07 ? 459 ALA A CB 1 ATOM 3332 N N . TRP A 1 432 ? 48.119 -17.550 0.625 1.00 23.24 ? 460 TRP A N 1 ATOM 3333 C CA . TRP A 1 432 ? 48.288 -17.743 -0.821 1.00 22.85 ? 460 TRP A CA 1 ATOM 3334 C C . TRP A 1 432 ? 49.665 -17.264 -1.285 1.00 22.43 ? 460 TRP A C 1 ATOM 3335 O O . TRP A 1 432 ? 50.368 -17.964 -2.022 1.00 22.15 ? 460 TRP A O 1 ATOM 3336 C CB . TRP A 1 432 ? 47.169 -17.028 -1.593 1.00 22.43 ? 460 TRP A CB 1 ATOM 3337 C CG . TRP A 1 432 ? 47.206 -17.268 -3.060 1.00 22.54 ? 460 TRP A CG 1 ATOM 3338 C CD1 . TRP A 1 432 ? 46.843 -18.410 -3.710 1.00 21.20 ? 460 TRP A CD1 1 ATOM 3339 C CD2 . TRP A 1 432 ? 47.617 -16.342 -4.075 1.00 21.75 ? 460 TRP A CD2 1 ATOM 3340 N NE1 . TRP A 1 432 ? 47.022 -18.262 -5.064 1.00 21.52 ? 460 TRP A NE1 1 ATOM 3341 C CE2 . TRP A 1 432 ? 47.486 -17.001 -5.319 1.00 21.34 ? 460 TRP A CE2 1 ATOM 3342 C CE3 . TRP A 1 432 ? 48.083 -15.024 -4.053 1.00 21.49 ? 460 TRP A CE3 1 ATOM 3343 C CZ2 . TRP A 1 432 ? 47.803 -16.387 -6.539 1.00 21.82 ? 460 TRP A CZ2 1 ATOM 3344 C CZ3 . TRP A 1 432 ? 48.413 -14.411 -5.262 1.00 21.89 ? 460 TRP A CZ3 1 ATOM 3345 C CH2 . TRP A 1 432 ? 48.272 -15.097 -6.491 1.00 22.82 ? 460 TRP A CH2 1 ATOM 3346 N N . ASN A 1 433 ? 50.041 -16.075 -0.834 1.00 22.14 ? 461 ASN A N 1 ATOM 3347 C CA . ASN A 1 433 ? 51.340 -15.499 -1.134 1.00 22.12 ? 461 ASN A CA 1 ATOM 3348 C C . ASN A 1 433 ? 52.482 -16.339 -0.593 1.00 22.46 ? 461 ASN A C 1 ATOM 3349 O O . ASN A 1 433 ? 53.493 -16.537 -1.266 1.00 22.98 ? 461 ASN A O 1 ATOM 3350 C CB . ASN A 1 433 ? 51.413 -14.055 -0.602 1.00 21.88 ? 461 ASN A CB 1 ATOM 3351 C CG . ASN A 1 433 ? 50.875 -13.053 -1.602 1.00 20.82 ? 461 ASN A CG 1 ATOM 3352 O OD1 . ASN A 1 433 ? 51.607 -12.606 -2.496 1.00 20.40 ? 461 ASN A OD1 1 ATOM 3353 N ND2 . ASN A 1 433 ? 49.579 -12.736 -1.495 1.00 16.93 ? 461 ASN A ND2 1 ATOM 3354 N N . ARG A 1 434 ? 52.303 -16.847 0.616 1.00 22.60 ? 462 ARG A N 1 ATOM 3355 C CA . ARG A 1 434 ? 53.310 -17.654 1.262 1.00 23.12 ? 462 ARG A CA 1 ATOM 3356 C C . ARG A 1 434 ? 53.488 -18.982 0.536 1.00 22.71 ? 462 ARG A C 1 ATOM 3357 O O . ARG A 1 434 ? 54.610 -19.434 0.317 1.00 22.91 ? 462 ARG A O 1 ATOM 3358 C CB . ARG A 1 434 ? 52.932 -17.893 2.715 1.00 23.28 ? 462 ARG A CB 1 ATOM 3359 C CG . ARG A 1 434 ? 54.116 -18.158 3.611 1.00 26.28 ? 462 ARG A CG 1 ATOM 3360 C CD . ARG A 1 434 ? 53.782 -18.049 5.099 1.00 29.41 ? 462 ARG A CD 1 ATOM 3361 N NE . ARG A 1 434 ? 52.510 -18.689 5.414 1.00 32.02 ? 462 ARG A NE 1 ATOM 3362 C CZ . ARG A 1 434 ? 51.478 -18.035 5.928 1.00 32.25 ? 462 ARG A CZ 1 ATOM 3363 N NH1 . ARG A 1 434 ? 51.604 -16.738 6.203 1.00 29.82 ? 462 ARG A NH1 1 ATOM 3364 N NH2 . ARG A 1 434 ? 50.335 -18.683 6.166 1.00 33.59 ? 462 ARG A NH2 1 ATOM 3365 N N . ALA A 1 435 ? 52.376 -19.597 0.160 1.00 22.06 ? 463 ALA A N 1 ATOM 3366 C CA . ALA A 1 435 ? 52.412 -20.830 -0.602 1.00 21.45 ? 463 ALA A CA 1 ATOM 3367 C C . ALA A 1 435 ? 53.279 -20.648 -1.835 1.00 21.51 ? 463 ALA A C 1 ATOM 3368 O O . ALA A 1 435 ? 54.216 -21.427 -2.060 1.00 22.40 ? 463 ALA A O 1 ATOM 3369 C CB . ALA A 1 435 ? 51.005 -21.252 -0.995 1.00 21.26 ? 463 ALA A CB 1 ATOM 3370 N N . ILE A 1 436 ? 53.006 -19.613 -2.629 1.00 20.91 ? 464 ILE A N 1 ATOM 3371 C CA . ILE A 1 436 ? 53.754 -19.439 -3.875 1.00 20.15 ? 464 ILE A CA 1 ATOM 3372 C C . ILE A 1 436 ? 55.220 -19.112 -3.589 1.00 20.45 ? 464 ILE A C 1 ATOM 3373 O O . ILE A 1 436 ? 56.111 -19.634 -4.270 1.00 20.51 ? 464 ILE A O 1 ATOM 3374 C CB . ILE A 1 436 ? 53.035 -18.495 -4.897 1.00 19.82 ? 464 ILE A CB 1 ATOM 3375 C CG1 . ILE A 1 436 ? 51.848 -19.230 -5.518 1.00 17.86 ? 464 ILE A CG1 1 ATOM 3376 C CG2 . ILE A 1 436 ? 53.950 -18.120 -6.034 1.00 19.30 ? 464 ILE A CG2 1 ATOM 3377 C CD1 . ILE A 1 436 ? 50.660 -18.408 -5.748 1.00 14.86 ? 464 ILE A CD1 1 ATOM 3378 N N . ASP A 1 437 ? 55.462 -18.298 -2.558 1.00 20.39 ? 465 ASP A N 1 ATOM 3379 C CA . ASP A 1 437 ? 56.822 -17.927 -2.172 1.00 20.75 ? 465 ASP A CA 1 ATOM 3380 C C . ASP A 1 437 ? 57.653 -19.146 -1.804 1.00 20.64 ? 465 ASP A C 1 ATOM 3381 O O . ASP A 1 437 ? 58.816 -19.261 -2.203 1.00 20.97 ? 465 ASP A O 1 ATOM 3382 C CB . ASP A 1 437 ? 56.815 -16.947 -0.995 1.00 21.15 ? 465 ASP A CB 1 ATOM 3383 C CG . ASP A 1 437 ? 56.589 -15.482 -1.420 1.00 23.88 ? 465 ASP A CG 1 ATOM 3384 O OD1 . ASP A 1 437 ? 56.839 -15.099 -2.595 1.00 27.41 ? 465 ASP A OD1 1 ATOM 3385 O OD2 . ASP A 1 437 ? 56.174 -14.692 -0.544 1.00 26.05 ? 465 ASP A OD2 1 ATOM 3386 N N . MET A 1 438 ? 57.050 -20.050 -1.035 1.00 20.74 ? 466 MET A N 1 ATOM 3387 C CA . MET A 1 438 ? 57.741 -21.221 -0.509 1.00 20.63 ? 466 MET A CA 1 ATOM 3388 C C . MET A 1 438 ? 57.929 -22.261 -1.608 1.00 20.92 ? 466 MET A C 1 ATOM 3389 O O . MET A 1 438 ? 58.981 -22.879 -1.717 1.00 21.07 ? 466 MET A O 1 ATOM 3390 C CB . MET A 1 438 ? 56.997 -21.790 0.708 1.00 20.20 ? 466 MET A CB 1 ATOM 3391 C CG . MET A 1 438 ? 57.129 -20.907 1.934 1.00 20.33 ? 466 MET A CG 1 ATOM 3392 S SD . MET A 1 438 ? 56.228 -21.471 3.399 1.00 23.95 ? 466 MET A SD 1 ATOM 3393 C CE . MET A 1 438 ? 57.356 -22.702 4.110 1.00 20.55 ? 466 MET A CE 1 ATOM 3394 N N . LEU A 1 439 ? 56.920 -22.413 -2.455 1.00 21.34 ? 467 LEU A N 1 ATOM 3395 C CA . LEU A 1 439 ? 56.966 -23.394 -3.524 1.00 21.37 ? 467 LEU A CA 1 ATOM 3396 C C . LEU A 1 439 ? 57.781 -22.997 -4.744 1.00 21.73 ? 467 LEU A C 1 ATOM 3397 O O . LEU A 1 439 ? 58.287 -23.882 -5.436 1.00 21.43 ? 467 LEU A O 1 ATOM 3398 C CB . LEU A 1 439 ? 55.546 -23.783 -3.948 1.00 20.94 ? 467 LEU A CB 1 ATOM 3399 C CG . LEU A 1 439 ? 54.836 -24.787 -3.031 1.00 21.13 ? 467 LEU A CG 1 ATOM 3400 C CD1 . LEU A 1 439 ? 53.347 -24.866 -3.342 1.00 19.77 ? 467 LEU A CD1 1 ATOM 3401 C CD2 . LEU A 1 439 ? 55.469 -26.167 -3.114 1.00 19.52 ? 467 LEU A CD2 1 ATOM 3402 N N . TYR A 1 440 ? 57.906 -21.697 -5.029 1.00 22.38 ? 468 TYR A N 1 ATOM 3403 C CA . TYR A 1 440 ? 58.425 -21.285 -6.363 1.00 23.73 ? 468 TYR A CA 1 ATOM 3404 C C . TYR A 1 440 ? 59.767 -20.590 -6.407 1.00 25.08 ? 468 TYR A C 1 ATOM 3405 O O . TYR A 1 440 ? 60.371 -20.526 -7.470 1.00 25.76 ? 468 TYR A O 1 ATOM 3406 C CB . TYR A 1 440 ? 57.380 -20.528 -7.202 1.00 22.93 ? 468 TYR A CB 1 ATOM 3407 C CG . TYR A 1 440 ? 56.372 -21.485 -7.719 1.00 22.09 ? 468 TYR A CG 1 ATOM 3408 C CD1 . TYR A 1 440 ? 55.277 -21.848 -6.942 1.00 21.58 ? 468 TYR A CD1 1 ATOM 3409 C CD2 . TYR A 1 440 ? 56.542 -22.096 -8.950 1.00 22.24 ? 468 TYR A CD2 1 ATOM 3410 C CE1 . TYR A 1 440 ? 54.363 -22.777 -7.386 1.00 20.81 ? 468 TYR A CE1 1 ATOM 3411 C CE2 . TYR A 1 440 ? 55.637 -23.026 -9.403 1.00 22.25 ? 468 TYR A CE2 1 ATOM 3412 C CZ . TYR A 1 440 ? 54.548 -23.368 -8.616 1.00 21.75 ? 468 TYR A CZ 1 ATOM 3413 O OH . TYR A 1 440 ? 53.648 -24.315 -9.055 1.00 20.89 ? 468 TYR A OH 1 ATOM 3414 N N . GLY A 1 441 ? 60.223 -20.065 -5.271 1.00 26.24 ? 469 GLY A N 1 ATOM 3415 C CA . GLY A 1 441 ? 61.568 -19.502 -5.171 1.00 27.87 ? 469 GLY A CA 1 ATOM 3416 C C . GLY A 1 441 ? 61.808 -18.301 -6.079 1.00 28.94 ? 469 GLY A C 1 ATOM 3417 O O . GLY A 1 441 ? 61.061 -17.322 -6.040 1.00 29.18 ? 469 GLY A O 1 ATOM 3418 N N . ASP A 1 442 ? 62.853 -18.371 -6.896 1.00 29.25 ? 470 ASP A N 1 ATOM 3419 C CA . ASP A 1 442 ? 63.192 -17.277 -7.770 1.00 30.05 ? 470 ASP A CA 1 ATOM 3420 C C . ASP A 1 442 ? 61.981 -16.829 -8.614 1.00 29.17 ? 470 ASP A C 1 ATOM 3421 O O . ASP A 1 442 ? 61.857 -15.648 -8.942 1.00 29.01 ? 470 ASP A O 1 ATOM 3422 C CB . ASP A 1 442 ? 64.375 -17.686 -8.659 1.00 31.13 ? 470 ASP A CB 1 ATOM 3423 C CG . ASP A 1 442 ? 65.749 -17.390 -8.006 1.00 36.35 ? 470 ASP A CG 1 ATOM 3424 O OD1 . ASP A 1 442 ? 65.867 -17.341 -6.744 1.00 40.26 ? 470 ASP A OD1 1 ATOM 3425 O OD2 . ASP A 1 442 ? 66.732 -17.187 -8.772 1.00 41.57 ? 470 ASP A OD2 1 ATOM 3426 N N . LEU A 1 443 ? 61.087 -17.772 -8.938 1.00 27.98 ? 471 LEU A N 1 ATOM 3427 C CA . LEU A 1 443 ? 59.955 -17.524 -9.855 1.00 26.90 ? 471 LEU A CA 1 ATOM 3428 C C . LEU A 1 443 ? 58.646 -17.129 -9.190 1.00 26.50 ? 471 LEU A C 1 ATOM 3429 O O . LEU A 1 443 ? 57.632 -16.968 -9.867 1.00 26.70 ? 471 LEU A O 1 ATOM 3430 C CB . LEU A 1 443 ? 59.689 -18.737 -10.758 1.00 26.63 ? 471 LEU A CB 1 ATOM 3431 C CG . LEU A 1 443 ? 60.765 -19.175 -11.753 1.00 26.21 ? 471 LEU A CG 1 ATOM 3432 C CD1 . LEU A 1 443 ? 60.363 -20.483 -12.419 1.00 26.13 ? 471 LEU A CD1 1 ATOM 3433 C CD2 . LEU A 1 443 ? 61.039 -18.094 -12.793 1.00 25.69 ? 471 LEU A CD2 1 ATOM 3434 N N . ALA A 1 444 ? 58.663 -16.972 -7.875 1.00 25.95 ? 472 ALA A N 1 ATOM 3435 C CA . ALA A 1 444 ? 57.454 -16.716 -7.116 1.00 25.78 ? 472 ALA A CA 1 ATOM 3436 C C . ALA A 1 444 ? 56.681 -15.503 -7.604 1.00 26.12 ? 472 ALA A C 1 ATOM 3437 O O . ALA A 1 444 ? 55.460 -15.568 -7.749 1.00 25.87 ? 472 ALA A O 1 ATOM 3438 C CB . ALA A 1 444 ? 57.763 -16.586 -5.621 1.00 25.42 ? 472 ALA A CB 1 ATOM 3439 N N . GLU A 1 445 ? 57.380 -14.395 -7.843 1.00 26.76 ? 473 GLU A N 1 ATOM 3440 C CA . GLU A 1 445 ? 56.689 -13.161 -8.190 1.00 27.25 ? 473 GLU A CA 1 ATOM 3441 C C . GLU A 1 445 ? 55.921 -13.362 -9.482 1.00 26.30 ? 473 GLU A C 1 ATOM 3442 O O . GLU A 1 445 ? 54.737 -13.010 -9.557 1.00 26.36 ? 473 GLU A O 1 ATOM 3443 C CB . GLU A 1 445 ? 57.632 -11.954 -8.235 1.00 27.96 ? 473 GLU A CB 1 ATOM 3444 C CG . GLU A 1 445 ? 58.109 -11.503 -6.832 1.00 32.60 ? 473 GLU A CG 1 ATOM 3445 C CD . GLU A 1 445 ? 56.952 -11.010 -5.930 1.00 38.96 ? 473 GLU A CD 1 ATOM 3446 O OE1 . GLU A 1 445 ? 56.471 -9.862 -6.148 1.00 41.85 ? 473 GLU A OE1 1 ATOM 3447 O OE2 . GLU A 1 445 ? 56.528 -11.760 -5.004 1.00 40.27 ? 473 GLU A OE2 1 ATOM 3448 N N . ASP A 1 446 ? 56.557 -13.997 -10.464 1.00 24.76 ? 474 ASP A N 1 ATOM 3449 C CA . ASP A 1 446 ? 55.892 -14.226 -11.736 1.00 23.85 ? 474 ASP A CA 1 ATOM 3450 C C . ASP A 1 446 ? 54.767 -15.229 -11.631 1.00 23.04 ? 474 ASP A C 1 ATOM 3451 O O . ASP A 1 446 ? 53.724 -15.050 -12.251 1.00 23.00 ? 474 ASP A O 1 ATOM 3452 C CB . ASP A 1 446 ? 56.886 -14.629 -12.819 1.00 24.36 ? 474 ASP A CB 1 ATOM 3453 C CG . ASP A 1 446 ? 57.745 -13.462 -13.279 1.00 25.01 ? 474 ASP A CG 1 ATOM 3454 O OD1 . ASP A 1 446 ? 57.378 -12.299 -12.997 1.00 26.65 ? 474 ASP A OD1 1 ATOM 3455 O OD2 . ASP A 1 446 ? 58.784 -13.698 -13.924 1.00 24.96 ? 474 ASP A OD2 1 ATOM 3456 N N . MET A 1 447 ? 54.963 -16.276 -10.832 1.00 21.74 ? 475 MET A N 1 ATOM 3457 C CA . MET A 1 447 ? 53.912 -17.245 -10.647 1.00 20.48 ? 475 MET A CA 1 ATOM 3458 C C . MET A 1 447 ? 52.670 -16.597 -10.015 1.00 20.24 ? 475 MET A C 1 ATOM 3459 O O . MET A 1 447 ? 51.540 -16.895 -10.429 1.00 20.25 ? 475 MET A O 1 ATOM 3460 C CB . MET A 1 447 ? 54.396 -18.440 -9.835 1.00 20.45 ? 475 MET A CB 1 ATOM 3461 C CG . MET A 1 447 ? 53.427 -19.609 -9.845 1.00 18.81 ? 475 MET A CG 1 ATOM 3462 S SD . MET A 1 447 ? 53.380 -20.325 -11.503 1.00 19.94 ? 475 MET A SD 1 ATOM 3463 C CE . MET A 1 447 ? 52.098 -21.581 -11.306 1.00 17.72 ? 475 MET A CE 1 ATOM 3464 N N . LYS A 1 448 ? 52.873 -15.710 -9.034 1.00 19.38 ? 476 LYS A N 1 ATOM 3465 C CA . LYS A 1 448 ? 51.750 -14.962 -8.460 1.00 19.11 ? 476 LYS A CA 1 ATOM 3466 C C . LYS A 1 448 ? 50.965 -14.252 -9.560 1.00 19.01 ? 476 LYS A C 1 ATOM 3467 O O . LYS A 1 448 ? 49.742 -14.349 -9.604 1.00 19.27 ? 476 LYS A O 1 ATOM 3468 C CB . LYS A 1 448 ? 52.194 -13.944 -7.401 1.00 18.68 ? 476 LYS A CB 1 ATOM 3469 C CG . LYS A 1 448 ? 52.513 -14.548 -6.053 1.00 18.86 ? 476 LYS A CG 1 ATOM 3470 C CD . LYS A 1 448 ? 53.128 -13.500 -5.159 1.00 18.81 ? 476 LYS A CD 1 ATOM 3471 C CE . LYS A 1 448 ? 54.132 -14.139 -4.210 1.00 20.24 ? 476 LYS A CE 1 ATOM 3472 N NZ . LYS A 1 448 ? 54.640 -13.239 -3.147 1.00 18.94 ? 476 LYS A NZ 1 ATOM 3473 N N . VAL A 1 449 ? 51.670 -13.567 -10.458 1.00 18.60 ? 477 VAL A N 1 ATOM 3474 C CA . VAL A 1 449 ? 51.025 -12.828 -11.538 1.00 18.16 ? 477 VAL A CA 1 ATOM 3475 C C . VAL A 1 449 ? 50.091 -13.727 -12.362 1.00 18.19 ? 477 VAL A C 1 ATOM 3476 O O . VAL A 1 449 ? 48.948 -13.331 -12.674 1.00 18.19 ? 477 VAL A O 1 ATOM 3477 C CB . VAL A 1 449 ? 52.054 -12.118 -12.456 1.00 17.94 ? 477 VAL A CB 1 ATOM 3478 C CG1 . VAL A 1 449 ? 51.338 -11.472 -13.632 1.00 17.70 ? 477 VAL A CG1 1 ATOM 3479 C CG2 . VAL A 1 449 ? 52.822 -11.070 -11.669 1.00 15.23 ? 477 VAL A CG2 1 ATOM 3480 N N . PHE A 1 450 ? 50.570 -14.934 -12.670 1.00 17.66 ? 478 PHE A N 1 ATOM 3481 C CA . PHE A 1 450 ? 49.818 -15.910 -13.469 1.00 17.43 ? 478 PHE A CA 1 ATOM 3482 C C . PHE A 1 450 ? 48.691 -16.525 -12.654 1.00 17.61 ? 478 PHE A C 1 ATOM 3483 O O . PHE A 1 450 ? 47.517 -16.407 -13.016 1.00 17.74 ? 478 PHE A O 1 ATOM 3484 C CB . PHE A 1 450 ? 50.773 -16.981 -14.042 1.00 17.08 ? 478 PHE A CB 1 ATOM 3485 C CG . PHE A 1 450 ? 50.097 -18.253 -14.501 1.00 16.07 ? 478 PHE A CG 1 ATOM 3486 C CD1 . PHE A 1 450 ? 49.381 -18.293 -15.691 1.00 14.95 ? 478 PHE A CD1 1 ATOM 3487 C CD2 . PHE A 1 450 ? 50.204 -19.426 -13.743 1.00 13.42 ? 478 PHE A CD2 1 ATOM 3488 C CE1 . PHE A 1 450 ? 48.767 -19.485 -16.116 1.00 14.19 ? 478 PHE A CE1 1 ATOM 3489 C CE2 . PHE A 1 450 ? 49.596 -20.612 -14.149 1.00 11.53 ? 478 PHE A CE2 1 ATOM 3490 C CZ . PHE A 1 450 ? 48.884 -20.649 -15.342 1.00 13.69 ? 478 PHE A CZ 1 ATOM 3491 N N . ALA A 1 451 ? 49.051 -17.151 -11.538 1.00 18.17 ? 479 ALA A N 1 ATOM 3492 C CA . ALA A 1 451 ? 48.087 -17.807 -10.641 1.00 18.49 ? 479 ALA A CA 1 ATOM 3493 C C . ALA A 1 451 ? 46.969 -16.880 -10.186 1.00 18.38 ? 479 ALA A C 1 ATOM 3494 O O . ALA A 1 451 ? 45.835 -17.315 -10.037 1.00 18.70 ? 479 ALA A O 1 ATOM 3495 C CB . ALA A 1 451 ? 48.799 -18.389 -9.438 1.00 18.87 ? 479 ALA A CB 1 ATOM 3496 N N . ASN A 1 452 ? 47.292 -15.606 -9.994 1.00 18.21 ? 480 ASN A N 1 ATOM 3497 C CA . ASN A 1 452 ? 46.325 -14.593 -9.602 1.00 18.47 ? 480 ASN A CA 1 ATOM 3498 C C . ASN A 1 452 ? 45.087 -14.530 -10.495 1.00 18.48 ? 480 ASN A C 1 ATOM 3499 O O . ASN A 1 452 ? 43.985 -14.163 -10.042 1.00 17.93 ? 480 ASN A O 1 ATOM 3500 C CB . ASN A 1 452 ? 47.005 -13.238 -9.588 1.00 18.71 ? 480 ASN A CB 1 ATOM 3501 C CG . ASN A 1 452 ? 46.150 -12.149 -8.943 1.00 20.05 ? 480 ASN A CG 1 ATOM 3502 O OD1 . ASN A 1 452 ? 45.388 -12.399 -8.002 1.00 22.93 ? 480 ASN A OD1 1 ATOM 3503 N ND2 . ASN A 1 452 ? 46.287 -10.925 -9.445 1.00 19.68 ? 480 ASN A ND2 1 ATOM 3504 N N . HIS A 1 453 ? 45.275 -14.907 -11.761 1.00 18.40 ? 481 HIS A N 1 ATOM 3505 C CA . HIS A 1 453 ? 44.200 -14.914 -12.740 1.00 17.82 ? 481 HIS A CA 1 ATOM 3506 C C . HIS A 1 453 ? 43.508 -16.258 -12.810 1.00 17.73 ? 481 HIS A C 1 ATOM 3507 O O . HIS A 1 453 ? 42.715 -16.485 -13.703 1.00 17.25 ? 481 HIS A O 1 ATOM 3508 C CB . HIS A 1 453 ? 44.766 -14.605 -14.125 1.00 17.88 ? 481 HIS A CB 1 ATOM 3509 C CG . HIS A 1 453 ? 45.034 -13.156 -14.367 1.00 17.45 ? 481 HIS A CG 1 ATOM 3510 N ND1 . HIS A 1 453 ? 44.111 -12.320 -14.955 1.00 16.00 ? 481 HIS A ND1 1 ATOM 3511 C CD2 . HIS A 1 453 ? 46.131 -12.399 -14.121 1.00 17.46 ? 481 HIS A CD2 1 ATOM 3512 C CE1 . HIS A 1 453 ? 44.622 -11.106 -15.043 1.00 17.07 ? 481 HIS A CE1 1 ATOM 3513 N NE2 . HIS A 1 453 ? 45.850 -11.129 -14.554 1.00 17.70 ? 481 HIS A NE2 1 ATOM 3514 N N . SER A 1 454 ? 43.826 -17.169 -11.901 1.00 18.48 ? 482 SER A N 1 ATOM 3515 C CA . SER A 1 454 ? 43.322 -18.544 -12.020 1.00 19.32 ? 482 SER A CA 1 ATOM 3516 C C . SER A 1 454 ? 42.865 -19.162 -10.694 1.00 19.89 ? 482 SER A C 1 ATOM 3517 O O . SER A 1 454 ? 43.226 -20.294 -10.356 1.00 20.14 ? 482 SER A O 1 ATOM 3518 C CB . SER A 1 454 ? 44.368 -19.421 -12.698 1.00 18.67 ? 482 SER A CB 1 ATOM 3519 O OG . SER A 1 454 ? 43.736 -20.558 -13.214 1.00 19.85 ? 482 SER A OG 1 ATOM 3520 N N . THR A 1 455 ? 42.042 -18.420 -9.959 1.00 20.60 ? 483 THR A N 1 ATOM 3521 C CA . THR A 1 455 ? 41.662 -18.812 -8.614 1.00 21.13 ? 483 THR A CA 1 ATOM 3522 C C . THR A 1 455 ? 40.175 -19.140 -8.533 1.00 21.85 ? 483 THR A C 1 ATOM 3523 O O . THR A 1 455 ? 39.768 -19.888 -7.652 1.00 22.36 ? 483 THR A O 1 ATOM 3524 C CB . THR A 1 455 ? 42.069 -17.741 -7.558 1.00 21.17 ? 483 THR A CB 1 ATOM 3525 O OG1 . THR A 1 455 ? 41.453 -16.489 -7.874 1.00 22.16 ? 483 THR A OG1 1 ATOM 3526 C CG2 . THR A 1 455 ? 43.600 -17.534 -7.530 1.00 19.56 ? 483 THR A CG2 1 ATOM 3527 N N . ARG A 1 456 ? 39.385 -18.635 -9.486 1.00 22.21 ? 484 ARG A N 1 ATOM 3528 C CA . ARG A 1 456 ? 37.925 -18.786 -9.484 1.00 22.24 ? 484 ARG A CA 1 ATOM 3529 C C . ARG A 1 456 ? 37.396 -19.933 -10.365 1.00 22.74 ? 484 ARG A C 1 ATOM 3530 O O . ARG A 1 456 ? 37.607 -19.953 -11.572 1.00 23.24 ? 484 ARG A O 1 ATOM 3531 C CB . ARG A 1 456 ? 37.294 -17.470 -9.926 1.00 22.14 ? 484 ARG A CB 1 ATOM 3532 C CG . ARG A 1 456 ? 35.763 -17.447 -9.903 1.00 21.72 ? 484 ARG A CG 1 ATOM 3533 C CD . ARG A 1 456 ? 35.246 -17.390 -8.456 1.00 20.17 ? 484 ARG A CD 1 ATOM 3534 N NE . ARG A 1 456 ? 33.796 -17.487 -8.435 1.00 20.87 ? 484 ARG A NE 1 ATOM 3535 C CZ . ARG A 1 456 ? 33.059 -17.738 -7.356 1.00 21.32 ? 484 ARG A CZ 1 ATOM 3536 N NH1 . ARG A 1 456 ? 33.631 -17.933 -6.163 1.00 19.33 ? 484 ARG A NH1 1 ATOM 3537 N NH2 . ARG A 1 456 ? 31.737 -17.797 -7.483 1.00 20.31 ? 484 ARG A NH2 1 ATOM 3538 N N . MET A 1 457 ? 36.695 -20.884 -9.768 1.00 23.46 ? 485 MET A N 1 ATOM 3539 C CA . MET A 1 457 ? 36.076 -21.961 -10.545 1.00 24.53 ? 485 MET A CA 1 ATOM 3540 C C . MET A 1 457 ? 34.585 -21.685 -10.677 1.00 25.42 ? 485 MET A C 1 ATOM 3541 O O . MET A 1 457 ? 33.906 -21.477 -9.675 1.00 25.57 ? 485 MET A O 1 ATOM 3542 C CB . MET A 1 457 ? 36.294 -23.319 -9.883 1.00 24.14 ? 485 MET A CB 1 ATOM 3543 C CG . MET A 1 457 ? 37.742 -23.769 -9.829 1.00 25.22 ? 485 MET A CG 1 ATOM 3544 S SD . MET A 1 457 ? 38.444 -23.991 -11.466 1.00 26.49 ? 485 MET A SD 1 ATOM 3545 C CE . MET A 1 457 ? 37.418 -25.328 -12.074 1.00 25.14 ? 485 MET A CE 1 ATOM 3546 N N . ASP A 1 458 ? 34.098 -21.669 -11.916 1.00 26.39 ? 486 ASP A N 1 ATOM 3547 C CA . ASP A 1 458 ? 32.707 -21.397 -12.230 1.00 27.64 ? 486 ASP A CA 1 ATOM 3548 C C . ASP A 1 458 ? 32.348 -22.077 -13.555 1.00 27.97 ? 486 ASP A C 1 ATOM 3549 O O . ASP A 1 458 ? 32.724 -21.574 -14.626 1.00 27.84 ? 486 ASP A O 1 ATOM 3550 C CB . ASP A 1 458 ? 32.475 -19.881 -12.331 1.00 27.96 ? 486 ASP A CB 1 ATOM 3551 C CG . ASP A 1 458 ? 30.975 -19.489 -12.405 1.00 31.03 ? 486 ASP A CG 1 ATOM 3552 O OD1 . ASP A 1 458 ? 30.084 -20.377 -12.553 1.00 33.17 ? 486 ASP A OD1 1 ATOM 3553 O OD2 . ASP A 1 458 ? 30.688 -18.266 -12.313 1.00 32.74 ? 486 ASP A OD2 1 ATOM 3554 N N . ASN A 1 459 ? 31.635 -23.210 -13.472 1.00 28.42 ? 487 ASN A N 1 ATOM 3555 C CA . ASN A 1 459 ? 31.108 -23.913 -14.659 1.00 29.51 ? 487 ASN A CA 1 ATOM 3556 C C . ASN A 1 459 ? 29.797 -23.313 -15.239 1.00 30.65 ? 487 ASN A C 1 ATOM 3557 O O . ASN A 1 459 ? 29.188 -23.883 -16.141 1.00 30.65 ? 487 ASN A O 1 ATOM 3558 C CB . ASN A 1 459 ? 30.949 -25.410 -14.384 1.00 28.87 ? 487 ASN A CB 1 ATOM 3559 C CG . ASN A 1 459 ? 29.666 -25.741 -13.638 1.00 29.53 ? 487 ASN A CG 1 ATOM 3560 O OD1 . ASN A 1 459 ? 29.053 -24.881 -12.989 1.00 30.33 ? 487 ASN A OD1 1 ATOM 3561 N ND2 . ASN A 1 459 ? 29.251 -26.998 -13.723 1.00 28.00 ? 487 ASN A ND2 1 ATOM 3562 N N . LYS A 1 460 ? 29.385 -22.157 -14.707 1.00 32.58 ? 488 LYS A N 1 ATOM 3563 C CA . LYS A 1 460 ? 28.226 -21.361 -15.190 1.00 34.13 ? 488 LYS A CA 1 ATOM 3564 C C . LYS A 1 460 ? 26.888 -21.923 -14.727 1.00 34.60 ? 488 LYS A C 1 ATOM 3565 O O . LYS A 1 460 ? 25.865 -21.269 -14.897 1.00 35.18 ? 488 LYS A O 1 ATOM 3566 C CB . LYS A 1 460 ? 28.197 -21.162 -16.736 1.00 34.44 ? 488 LYS A CB 1 ATOM 3567 C CG . LYS A 1 460 ? 29.417 -20.462 -17.387 1.00 36.50 ? 488 LYS A CG 1 ATOM 3568 C CD . LYS A 1 460 ? 29.920 -19.232 -16.594 1.00 40.10 ? 488 LYS A CD 1 ATOM 3569 C CE . LYS A 1 460 ? 29.273 -17.916 -17.026 1.00 42.90 ? 488 LYS A CE 1 ATOM 3570 N NZ . LYS A 1 460 ? 29.852 -16.757 -16.261 1.00 45.42 ? 488 LYS A NZ 1 ATOM 3571 N N . THR A 1 461 ? 26.880 -23.137 -14.172 1.00 34.57 ? 489 THR A N 1 ATOM 3572 C CA . THR A 1 461 ? 25.651 -23.707 -13.609 1.00 34.24 ? 489 THR A CA 1 ATOM 3573 C C . THR A 1 461 ? 25.774 -23.955 -12.103 1.00 33.97 ? 489 THR A C 1 ATOM 3574 O O . THR A 1 461 ? 25.769 -23.012 -11.301 1.00 34.03 ? 489 THR A O 1 ATOM 3575 C CB . THR A 1 461 ? 25.180 -25.016 -14.338 1.00 34.41 ? 489 THR A CB 1 ATOM 3576 O OG1 . THR A 1 461 ? 26.137 -26.061 -14.156 1.00 35.55 ? 489 THR A OG1 1 ATOM 3577 C CG2 . THR A 1 461 ? 24.952 -24.795 -15.845 1.00 35.35 ? 489 THR A CG2 1 ATOM 3578 N N . TRP A 1 462 ? 25.912 -25.229 -11.742 1.00 33.62 ? 490 TRP A N 1 ATOM 3579 C CA . TRP A 1 462 ? 25.844 -25.681 -10.357 1.00 33.29 ? 490 TRP A CA 1 ATOM 3580 C C . TRP A 1 462 ? 27.141 -25.515 -9.543 1.00 32.99 ? 490 TRP A C 1 ATOM 3581 O O . TRP A 1 462 ? 27.081 -25.438 -8.321 1.00 33.25 ? 490 TRP A O 1 ATOM 3582 C CB . TRP A 1 462 ? 25.376 -27.141 -10.312 1.00 33.15 ? 490 TRP A CB 1 ATOM 3583 C CG . TRP A 1 462 ? 26.315 -28.104 -10.998 1.00 33.01 ? 490 TRP A CG 1 ATOM 3584 C CD1 . TRP A 1 462 ? 26.263 -28.514 -12.296 1.00 32.25 ? 490 TRP A CD1 1 ATOM 3585 C CD2 . TRP A 1 462 ? 27.442 -28.779 -10.407 1.00 32.92 ? 490 TRP A CD2 1 ATOM 3586 N NE1 . TRP A 1 462 ? 27.291 -29.397 -12.556 1.00 32.76 ? 490 TRP A NE1 1 ATOM 3587 C CE2 . TRP A 1 462 ? 28.028 -29.576 -11.415 1.00 32.64 ? 490 TRP A CE2 1 ATOM 3588 C CE3 . TRP A 1 462 ? 28.018 -28.772 -9.128 1.00 33.13 ? 490 TRP A CE3 1 ATOM 3589 C CZ2 . TRP A 1 462 ? 29.166 -30.369 -11.186 1.00 33.65 ? 490 TRP A CZ2 1 ATOM 3590 C CZ3 . TRP A 1 462 ? 29.150 -29.568 -8.898 1.00 34.22 ? 490 TRP A CZ3 1 ATOM 3591 C CH2 . TRP A 1 462 ? 29.711 -30.354 -9.926 1.00 33.23 ? 490 TRP A CH2 1 ATOM 3592 N N . ALA A 1 463 ? 28.295 -25.452 -10.213 1.00 32.46 ? 491 ALA A N 1 ATOM 3593 C CA . ALA A 1 463 ? 29.602 -25.441 -9.528 1.00 31.88 ? 491 ALA A CA 1 ATOM 3594 C C . ALA A 1 463 ? 30.276 -24.076 -9.543 1.00 31.83 ? 491 ALA A C 1 ATOM 3595 O O . ALA A 1 463 ? 30.582 -23.539 -10.612 1.00 32.28 ? 491 ALA A O 1 ATOM 3596 C CB . ALA A 1 463 ? 30.524 -26.478 -10.130 1.00 31.62 ? 491 ALA A CB 1 ATOM 3597 N N . LYS A 1 464 ? 30.500 -23.512 -8.358 1.00 31.32 ? 492 LYS A N 1 ATOM 3598 C CA . LYS A 1 464 ? 31.116 -22.184 -8.207 1.00 31.06 ? 492 LYS A CA 1 ATOM 3599 C C . LYS A 1 464 ? 31.891 -22.168 -6.898 1.00 29.94 ? 492 LYS A C 1 ATOM 3600 O O . LYS A 1 464 ? 31.296 -22.421 -5.847 1.00 29.93 ? 492 LYS A O 1 ATOM 3601 C CB . LYS A 1 464 ? 30.052 -21.073 -8.124 1.00 31.72 ? 492 LYS A CB 1 ATOM 3602 C CG . LYS A 1 464 ? 29.104 -20.946 -9.317 1.00 35.50 ? 492 LYS A CG 1 ATOM 3603 C CD . LYS A 1 464 ? 27.879 -20.050 -8.996 1.00 40.60 ? 492 LYS A CD 1 ATOM 3604 C CE . LYS A 1 464 ? 26.945 -19.862 -10.234 1.00 43.22 ? 492 LYS A CE 1 ATOM 3605 N NZ . LYS A 1 464 ? 27.482 -18.934 -11.317 1.00 43.41 ? 492 LYS A NZ 1 ATOM 3606 N N . SER A 1 465 ? 33.196 -21.889 -6.942 1.00 28.18 ? 493 SER A N 1 ATOM 3607 C CA . SER A 1 465 ? 33.969 -21.680 -5.707 1.00 26.69 ? 493 SER A CA 1 ATOM 3608 C C . SER A 1 465 ? 35.331 -21.027 -5.917 1.00 25.89 ? 493 SER A C 1 ATOM 3609 O O . SER A 1 465 ? 35.891 -21.081 -7.009 1.00 25.92 ? 493 SER A O 1 ATOM 3610 C CB . SER A 1 465 ? 34.162 -22.991 -4.947 1.00 26.86 ? 493 SER A CB 1 ATOM 3611 O OG . SER A 1 465 ? 34.699 -22.730 -3.655 1.00 26.26 ? 493 SER A OG 1 ATOM 3612 N N . GLY A 1 466 ? 35.865 -20.426 -4.861 1.00 24.83 ? 494 GLY A N 1 ATOM 3613 C CA . GLY A 1 466 ? 37.206 -19.876 -4.895 1.00 23.98 ? 494 GLY A CA 1 ATOM 3614 C C . GLY A 1 466 ? 37.229 -18.372 -4.910 1.00 23.95 ? 494 GLY A C 1 ATOM 3615 O O . GLY A 1 466 ? 36.264 -17.734 -5.286 1.00 23.55 ? 494 GLY A O 1 ATOM 3616 N N . ARG A 1 467 ? 38.348 -17.803 -4.491 1.00 24.73 ? 495 ARG A N 1 ATOM 3617 C CA . ARG A 1 467 ? 38.549 -16.356 -4.536 1.00 25.59 ? 495 ARG A CA 1 ATOM 3618 C C . ARG A 1 467 ? 38.368 -15.867 -5.971 1.00 26.52 ? 495 ARG A C 1 ATOM 3619 O O . ARG A 1 467 ? 38.758 -16.558 -6.918 1.00 26.73 ? 495 ARG A O 1 ATOM 3620 C CB . ARG A 1 467 ? 39.954 -16.022 -4.054 1.00 25.03 ? 495 ARG A CB 1 ATOM 3621 C CG . ARG A 1 467 ? 40.159 -14.589 -3.625 1.00 24.65 ? 495 ARG A CG 1 ATOM 3622 C CD . ARG A 1 467 ? 41.575 -14.124 -3.904 1.00 23.31 ? 495 ARG A CD 1 ATOM 3623 N NE . ARG A 1 467 ? 41.837 -14.122 -5.344 1.00 24.06 ? 495 ARG A NE 1 ATOM 3624 C CZ . ARG A 1 467 ? 43.036 -13.997 -5.900 1.00 21.88 ? 495 ARG A CZ 1 ATOM 3625 N NH1 . ARG A 1 467 ? 44.110 -13.875 -5.139 1.00 21.80 ? 495 ARG A NH1 1 ATOM 3626 N NH2 . ARG A 1 467 ? 43.158 -14.011 -7.220 1.00 21.01 ? 495 ARG A NH2 1 ATOM 3627 N N . GLU A 1 468 ? 37.753 -14.700 -6.137 1.00 27.69 ? 496 GLU A N 1 ATOM 3628 C CA . GLU A 1 468 ? 37.598 -14.113 -7.471 1.00 28.75 ? 496 GLU A CA 1 ATOM 3629 C C . GLU A 1 468 ? 38.974 -13.958 -8.155 1.00 28.20 ? 496 GLU A C 1 ATOM 3630 O O . GLU A 1 468 ? 40.018 -13.864 -7.483 1.00 28.02 ? 496 GLU A O 1 ATOM 3631 C CB . GLU A 1 468 ? 36.794 -12.797 -7.429 1.00 29.28 ? 496 GLU A CB 1 ATOM 3632 C CG . GLU A 1 468 ? 35.236 -12.984 -7.411 1.00 35.38 ? 496 GLU A CG 1 ATOM 3633 C CD . GLU A 1 468 ? 34.466 -11.830 -6.682 1.00 43.79 ? 496 GLU A CD 1 ATOM 3634 O OE1 . GLU A 1 468 ? 34.995 -11.283 -5.674 1.00 44.39 ? 496 GLU A OE1 1 ATOM 3635 O OE2 . GLU A 1 468 ? 33.319 -11.475 -7.107 1.00 47.45 ? 496 GLU A OE2 1 ATOM 3636 N N . ASP A 1 469 ? 38.959 -14.012 -9.488 1.00 27.52 ? 497 ASP A N 1 ATOM 3637 C CA . ASP A 1 469 ? 40.138 -13.816 -10.301 1.00 27.12 ? 497 ASP A CA 1 ATOM 3638 C C . ASP A 1 469 ? 40.595 -12.372 -10.202 1.00 27.29 ? 497 ASP A C 1 ATOM 3639 O O . ASP A 1 469 ? 39.767 -11.468 -10.268 1.00 27.94 ? 497 ASP A O 1 ATOM 3640 C CB . ASP A 1 469 ? 39.839 -14.192 -11.753 1.00 26.42 ? 497 ASP A CB 1 ATOM 3641 C CG . ASP A 1 469 ? 39.847 -15.690 -11.982 1.00 26.75 ? 497 ASP A CG 1 ATOM 3642 O OD1 . ASP A 1 469 ? 40.503 -16.425 -11.219 1.00 27.14 ? 497 ASP A OD1 1 ATOM 3643 O OD2 . ASP A 1 469 ? 39.210 -16.155 -12.947 1.00 28.08 ? 497 ASP A OD2 1 ATOM 3644 N N . ALA A 1 470 ? 41.906 -12.175 -10.027 1.00 27.73 ? 498 ALA A N 1 ATOM 3645 C CA . ALA A 1 470 ? 42.576 -10.860 -9.961 1.00 28.07 ? 498 ALA A CA 1 ATOM 3646 C C . ALA A 1 470 ? 41.658 -9.663 -9.657 1.00 28.77 ? 498 ALA A C 1 ATOM 3647 O O . ALA A 1 470 ? 41.425 -8.831 -10.524 1.00 27.85 ? 498 ALA A O 1 ATOM 3648 C CB . ALA A 1 470 ? 43.388 -10.615 -11.242 1.00 27.93 ? 498 ALA A CB 1 ATOM 3649 N N . PRO A 1 471 ? 41.145 -9.577 -8.413 1.00 29.91 ? 499 PRO A N 1 ATOM 3650 C CA . PRO A 1 471 ? 40.108 -8.586 -8.052 1.00 30.57 ? 499 PRO A CA 1 ATOM 3651 C C . PRO A 1 471 ? 40.570 -7.129 -8.204 1.00 31.42 ? 499 PRO A C 1 ATOM 3652 O O . PRO A 1 471 ? 39.769 -6.280 -8.613 1.00 31.10 ? 499 PRO A O 1 ATOM 3653 C CB . PRO A 1 471 ? 39.797 -8.895 -6.578 1.00 30.37 ? 499 PRO A CB 1 ATOM 3654 C CG . PRO A 1 471 ? 40.440 -10.242 -6.319 1.00 31.31 ? 499 PRO A CG 1 ATOM 3655 C CD . PRO A 1 471 ? 41.608 -10.345 -7.244 1.00 29.90 ? 499 PRO A CD 1 ATOM 3656 N N . GLU A 1 472 ? 41.842 -6.855 -7.894 1.00 32.11 ? 500 GLU A N 1 ATOM 3657 C CA . GLU A 1 472 ? 42.371 -5.495 -7.933 1.00 33.45 ? 500 GLU A CA 1 ATOM 3658 C C . GLU A 1 472 ? 42.399 -4.962 -9.364 1.00 33.50 ? 500 GLU A C 1 ATOM 3659 O O . GLU A 1 472 ? 42.178 -3.761 -9.577 1.00 34.74 ? 500 GLU A O 1 ATOM 3660 C CB . GLU A 1 472 ? 43.773 -5.384 -7.294 1.00 34.19 ? 500 GLU A CB 1 ATOM 3661 C CG . GLU A 1 472 ? 44.035 -6.279 -6.047 1.00 37.97 ? 500 GLU A CG 1 ATOM 3662 C CD . GLU A 1 472 ? 44.562 -7.701 -6.409 1.00 43.01 ? 500 GLU A CD 1 ATOM 3663 O OE1 . GLU A 1 472 ? 44.732 -8.033 -7.628 1.00 44.26 ? 500 GLU A OE1 1 ATOM 3664 O OE2 . GLU A 1 472 ? 44.804 -8.484 -5.459 1.00 42.95 ? 500 GLU A OE2 1 ATOM 3665 N N . LEU A 1 473 ? 42.682 -5.844 -10.324 1.00 32.67 ? 501 LEU A N 1 ATOM 3666 C CA . LEU A 1 473 ? 42.646 -5.531 -11.750 1.00 31.90 ? 501 LEU A CA 1 ATOM 3667 C C . LEU A 1 473 ? 41.212 -5.288 -12.253 1.00 32.12 ? 501 LEU A C 1 ATOM 3668 O O . LEU A 1 473 ? 40.960 -4.355 -13.013 1.00 32.11 ? 501 LEU A O 1 ATOM 3669 C CB . LEU A 1 473 ? 43.297 -6.669 -12.545 1.00 31.67 ? 501 LEU A CB 1 ATOM 3670 C CG . LEU A 1 473 ? 43.510 -6.465 -14.049 1.00 31.41 ? 501 LEU A CG 1 ATOM 3671 C CD1 . LEU A 1 473 ? 44.446 -5.310 -14.258 1.00 34.25 ? 501 LEU A CD1 1 ATOM 3672 C CD2 . LEU A 1 473 ? 44.099 -7.675 -14.700 1.00 29.69 ? 501 LEU A CD2 1 ATOM 3673 N N . ARG A 1 474 ? 40.287 -6.143 -11.826 1.00 32.07 ? 502 ARG A N 1 ATOM 3674 C CA . ARG A 1 474 ? 38.879 -6.029 -12.139 1.00 32.39 ? 502 ARG A CA 1 ATOM 3675 C C . ARG A 1 474 ? 38.318 -4.697 -11.657 1.00 33.09 ? 502 ARG A C 1 ATOM 3676 O O . ARG A 1 474 ? 37.391 -4.158 -12.261 1.00 33.60 ? 502 ARG A O 1 ATOM 3677 C CB . ARG A 1 474 ? 38.115 -7.168 -11.461 1.00 32.04 ? 502 ARG A CB 1 ATOM 3678 C CG . ARG A 1 474 ? 36.605 -7.219 -11.711 1.00 31.91 ? 502 ARG A CG 1 ATOM 3679 C CD . ARG A 1 474 ? 36.254 -7.510 -13.174 1.00 31.76 ? 502 ARG A CD 1 ATOM 3680 N NE . ARG A 1 474 ? 36.124 -6.283 -13.967 1.00 32.19 ? 502 ARG A NE 1 ATOM 3681 C CZ . ARG A 1 474 ? 35.867 -6.249 -15.280 1.00 31.87 ? 502 ARG A CZ 1 ATOM 3682 N NH1 . ARG A 1 474 ? 35.728 -7.371 -15.975 1.00 29.77 ? 502 ARG A NH1 1 ATOM 3683 N NH2 . ARG A 1 474 ? 35.760 -5.087 -15.913 1.00 31.89 ? 502 ARG A NH2 1 ATOM 3684 N N . ALA A 1 475 ? 38.880 -4.195 -10.558 1.00 33.31 ? 503 ALA A N 1 ATOM 3685 C CA . ALA A 1 475 ? 38.440 -2.955 -9.927 1.00 33.47 ? 503 ALA A CA 1 ATOM 3686 C C . ALA A 1 475 ? 38.890 -1.773 -10.783 1.00 33.46 ? 503 ALA A C 1 ATOM 3687 O O . ALA A 1 475 ? 38.104 -0.852 -11.045 1.00 33.16 ? 503 ALA A O 1 ATOM 3688 C CB . ALA A 1 475 ? 38.993 -2.847 -8.480 1.00 33.05 ? 503 ALA A CB 1 ATOM 3689 N N . LYS A 1 476 ? 40.156 -1.813 -11.209 1.00 33.44 ? 504 LYS A N 1 ATOM 3690 C CA . LYS A 1 476 ? 40.698 -0.849 -12.163 1.00 33.52 ? 504 LYS A CA 1 ATOM 3691 C C . LYS A 1 476 ? 39.946 -0.844 -13.508 1.00 33.82 ? 504 LYS A C 1 ATOM 3692 O O . LYS A 1 476 ? 39.621 0.224 -14.033 1.00 33.76 ? 504 LYS A O 1 ATOM 3693 C CB . LYS A 1 476 ? 42.188 -1.078 -12.375 1.00 33.39 ? 504 LYS A CB 1 ATOM 3694 C CG . LYS A 1 476 ? 43.013 -0.837 -11.132 1.00 34.52 ? 504 LYS A CG 1 ATOM 3695 C CD . LYS A 1 476 ? 44.496 -1.002 -11.410 1.00 37.11 ? 504 LYS A CD 1 ATOM 3696 C CE . LYS A 1 476 ? 45.329 -0.934 -10.124 1.00 39.02 ? 504 LYS A CE 1 ATOM 3697 N NZ . LYS A 1 476 ? 46.667 -0.327 -10.387 1.00 39.74 ? 504 LYS A NZ 1 ATOM 3698 N N . MET A 1 477 ? 39.654 -2.025 -14.054 1.00 33.94 ? 505 MET A N 1 ATOM 3699 C CA . MET A 1 477 ? 38.857 -2.103 -15.272 1.00 34.16 ? 505 MET A CA 1 ATOM 3700 C C . MET A 1 477 ? 37.478 -1.450 -15.107 1.00 34.66 ? 505 MET A C 1 ATOM 3701 O O . MET A 1 477 ? 37.075 -0.618 -15.930 1.00 34.56 ? 505 MET A O 1 ATOM 3702 C CB . MET A 1 477 ? 38.718 -3.544 -15.741 1.00 33.93 ? 505 MET A CB 1 ATOM 3703 C CG . MET A 1 477 ? 40.020 -4.176 -16.249 1.00 33.45 ? 505 MET A CG 1 ATOM 3704 S SD . MET A 1 477 ? 39.788 -5.960 -16.433 1.00 29.95 ? 505 MET A SD 1 ATOM 3705 C CE . MET A 1 477 ? 41.259 -6.418 -17.367 1.00 33.59 ? 505 MET A CE 1 ATOM 3706 N N . ASP A 1 478 ? 36.769 -1.836 -14.048 1.00 35.54 ? 506 ASP A N 1 ATOM 3707 C CA . ASP A 1 478 ? 35.461 -1.274 -13.710 1.00 36.45 ? 506 ASP A CA 1 ATOM 3708 C C . ASP A 1 478 ? 35.552 0.272 -13.601 1.00 36.83 ? 506 ASP A C 1 ATOM 3709 O O . ASP A 1 478 ? 34.763 1.006 -14.221 1.00 36.96 ? 506 ASP A O 1 ATOM 3710 C CB . ASP A 1 478 ? 34.942 -1.912 -12.409 1.00 36.34 ? 506 ASP A CB 1 ATOM 3711 C CG . ASP A 1 478 ? 34.365 -3.326 -12.617 1.00 38.31 ? 506 ASP A CG 1 ATOM 3712 O OD1 . ASP A 1 478 ? 34.101 -3.724 -13.775 1.00 38.96 ? 506 ASP A OD1 1 ATOM 3713 O OD2 . ASP A 1 478 ? 34.150 -4.050 -11.611 1.00 39.78 ? 506 ASP A OD2 1 ATOM 3714 N N . GLU A 1 479 ? 36.538 0.734 -12.833 1.00 37.01 ? 507 GLU A N 1 ATOM 3715 C CA . GLU A 1 479 ? 36.878 2.140 -12.690 1.00 37.92 ? 507 GLU A CA 1 ATOM 3716 C C . GLU A 1 479 ? 37.104 2.851 -14.047 1.00 37.42 ? 507 GLU A C 1 ATOM 3717 O O . GLU A 1 479 ? 36.579 3.940 -14.273 1.00 38.01 ? 507 GLU A O 1 ATOM 3718 C CB . GLU A 1 479 ? 38.086 2.264 -11.756 1.00 38.39 ? 507 GLU A CB 1 ATOM 3719 C CG . GLU A 1 479 ? 38.834 3.573 -11.818 1.00 43.10 ? 507 GLU A CG 1 ATOM 3720 C CD . GLU A 1 479 ? 38.389 4.585 -10.775 1.00 49.48 ? 507 GLU A CD 1 ATOM 3721 O OE1 . GLU A 1 479 ? 37.150 4.818 -10.628 1.00 52.50 ? 507 GLU A OE1 1 ATOM 3722 O OE2 . GLU A 1 479 ? 39.302 5.148 -10.107 1.00 51.64 ? 507 GLU A OE2 1 ATOM 3723 N N . LEU A 1 480 ? 37.850 2.232 -14.955 1.00 36.93 ? 508 LEU A N 1 ATOM 3724 C CA . LEU A 1 480 ? 38.005 2.767 -16.309 1.00 36.47 ? 508 LEU A CA 1 ATOM 3725 C C . LEU A 1 480 ? 36.696 2.979 -17.084 1.00 36.53 ? 508 LEU A C 1 ATOM 3726 O O . LEU A 1 480 ? 36.509 4.029 -17.672 1.00 35.93 ? 508 LEU A O 1 ATOM 3727 C CB . LEU A 1 480 ? 38.966 1.919 -17.136 1.00 36.39 ? 508 LEU A CB 1 ATOM 3728 C CG . LEU A 1 480 ? 39.256 2.463 -18.541 1.00 36.00 ? 508 LEU A CG 1 ATOM 3729 C CD1 . LEU A 1 480 ? 40.174 3.688 -18.477 1.00 34.79 ? 508 LEU A CD1 1 ATOM 3730 C CD2 . LEU A 1 480 ? 39.830 1.373 -19.437 1.00 34.48 ? 508 LEU A CD2 1 ATOM 3731 N N . TRP A 1 481 ? 35.796 1.996 -17.094 1.00 37.29 ? 509 TRP A N 1 ATOM 3732 C CA . TRP A 1 481 ? 34.498 2.210 -17.742 1.00 38.32 ? 509 TRP A CA 1 ATOM 3733 C C . TRP A 1 481 ? 33.712 3.379 -17.126 1.00 39.19 ? 509 TRP A C 1 ATOM 3734 O O . TRP A 1 481 ? 32.991 4.074 -17.847 1.00 39.11 ? 509 TRP A O 1 ATOM 3735 C CB . TRP A 1 481 ? 33.644 0.943 -17.808 1.00 37.87 ? 509 TRP A CB 1 ATOM 3736 C CG . TRP A 1 481 ? 34.293 -0.159 -18.584 1.00 39.32 ? 509 TRP A CG 1 ATOM 3737 C CD1 . TRP A 1 481 ? 34.526 -1.435 -18.146 1.00 39.94 ? 509 TRP A CD1 1 ATOM 3738 C CD2 . TRP A 1 481 ? 34.827 -0.092 -19.919 1.00 39.39 ? 509 TRP A CD2 1 ATOM 3739 N NE1 . TRP A 1 481 ? 35.159 -2.163 -19.120 1.00 39.82 ? 509 TRP A NE1 1 ATOM 3740 C CE2 . TRP A 1 481 ? 35.356 -1.369 -20.219 1.00 39.76 ? 509 TRP A CE2 1 ATOM 3741 C CE3 . TRP A 1 481 ? 34.902 0.917 -20.894 1.00 38.79 ? 509 TRP A CE3 1 ATOM 3742 C CZ2 . TRP A 1 481 ? 35.951 -1.667 -21.453 1.00 39.74 ? 509 TRP A CZ2 1 ATOM 3743 C CZ3 . TRP A 1 481 ? 35.493 0.619 -22.125 1.00 38.46 ? 509 TRP A CZ3 1 ATOM 3744 C CH2 . TRP A 1 481 ? 36.011 -0.662 -22.389 1.00 39.32 ? 509 TRP A CH2 1 ATOM 3745 N N . ASN A 1 482 ? 33.876 3.594 -15.815 1.00 40.15 ? 510 ASN A N 1 ATOM 3746 C CA . ASN A 1 482 ? 33.250 4.721 -15.121 1.00 41.19 ? 510 ASN A CA 1 ATOM 3747 C C . ASN A 1 482 ? 33.826 6.065 -15.523 1.00 40.88 ? 510 ASN A C 1 ATOM 3748 O O . ASN A 1 482 ? 33.075 6.989 -15.815 1.00 40.86 ? 510 ASN A O 1 ATOM 3749 C CB . ASN A 1 482 ? 33.296 4.544 -13.596 1.00 42.00 ? 510 ASN A CB 1 ATOM 3750 C CG . ASN A 1 482 ? 32.282 3.506 -13.097 1.00 44.70 ? 510 ASN A CG 1 ATOM 3751 O OD1 . ASN A 1 482 ? 31.100 3.545 -13.464 1.00 46.68 ? 510 ASN A OD1 1 ATOM 3752 N ND2 . ASN A 1 482 ? 32.745 2.572 -12.257 1.00 46.87 ? 510 ASN A ND2 1 ATOM 3753 N N . LYS A 1 483 ? 35.151 6.167 -15.555 1.00 40.80 ? 511 LYS A N 1 ATOM 3754 C CA . LYS A 1 483 ? 35.806 7.392 -15.998 1.00 41.12 ? 511 LYS A CA 1 ATOM 3755 C C . LYS A 1 483 ? 35.469 7.750 -17.462 1.00 41.59 ? 511 LYS A C 1 ATOM 3756 O O . LYS A 1 483 ? 35.516 8.918 -17.844 1.00 42.05 ? 511 LYS A O 1 ATOM 3757 C CB . LYS A 1 483 ? 37.315 7.307 -15.802 1.00 40.88 ? 511 LYS A CB 1 ATOM 3758 C CG . LYS A 1 483 ? 37.779 7.415 -14.352 1.00 42.32 ? 511 LYS A CG 1 ATOM 3759 C CD . LYS A 1 483 ? 39.269 7.793 -14.287 1.00 44.32 ? 511 LYS A CD 1 ATOM 3760 C CE . LYS A 1 483 ? 39.558 8.853 -13.204 1.00 46.53 ? 511 LYS A CE 1 ATOM 3761 N NZ . LYS A 1 483 ? 40.127 8.293 -11.936 1.00 47.44 ? 511 LYS A NZ 1 ATOM 3762 N N . LEU A 1 484 ? 35.109 6.756 -18.269 1.00 41.73 ? 512 LEU A N 1 ATOM 3763 C CA . LEU A 1 484 ? 34.858 6.989 -19.682 1.00 42.01 ? 512 LEU A CA 1 ATOM 3764 C C . LEU A 1 484 ? 33.414 7.376 -19.964 1.00 42.83 ? 512 LEU A C 1 ATOM 3765 O O . LEU A 1 484 ? 33.167 8.277 -20.773 1.00 43.17 ? 512 LEU A O 1 ATOM 3766 C CB . LEU A 1 484 ? 35.247 5.774 -20.536 1.00 41.77 ? 512 LEU A CB 1 ATOM 3767 C CG . LEU A 1 484 ? 36.727 5.379 -20.658 1.00 40.89 ? 512 LEU A CG 1 ATOM 3768 C CD1 . LEU A 1 484 ? 36.831 4.043 -21.375 1.00 39.69 ? 512 LEU A CD1 1 ATOM 3769 C CD2 . LEU A 1 484 ? 37.546 6.431 -21.366 1.00 40.04 ? 512 LEU A CD2 1 ATOM 3770 N N . SER A 1 485 ? 32.463 6.694 -19.321 1.00 43.42 ? 513 SER A N 1 ATOM 3771 C CA . SER A 1 485 ? 31.051 6.964 -19.575 1.00 44.11 ? 513 SER A CA 1 ATOM 3772 C C . SER A 1 485 ? 30.600 8.253 -18.879 1.00 44.69 ? 513 SER A C 1 ATOM 3773 O O . SER A 1 485 ? 29.566 8.826 -19.247 1.00 44.55 ? 513 SER A O 1 ATOM 3774 C CB . SER A 1 485 ? 30.148 5.761 -19.236 1.00 44.14 ? 513 SER A CB 1 ATOM 3775 O OG . SER A 1 485 ? 30.111 5.508 -17.845 1.00 44.37 ? 513 SER A OG 1 ATOM 3776 N N . SER A 1 486 ? 31.389 8.702 -17.896 1.00 45.32 ? 514 SER A N 1 ATOM 3777 C CA . SER A 1 486 ? 31.217 10.029 -17.294 1.00 46.20 ? 514 SER A CA 1 ATOM 3778 C C . SER A 1 486 ? 32.319 11.006 -17.765 1.00 46.97 ? 514 SER A C 1 ATOM 3779 O O . SER A 1 486 ? 32.668 11.983 -17.078 1.00 47.18 ? 514 SER A O 1 ATOM 3780 C CB . SER A 1 486 ? 31.119 9.936 -15.760 1.00 46.12 ? 514 SER A CB 1 ATOM 3781 O OG . SER A 1 486 ? 32.395 9.798 -15.165 1.00 46.67 ? 514 SER A OG 1 ATOM 3782 N N . LYS A 1 487 ? 32.856 10.715 -18.952 1.00 47.84 ? 515 LYS A N 1 ATOM 3783 C CA . LYS A 1 487 ? 33.881 11.529 -19.654 1.00 48.33 ? 515 LYS A CA 1 ATOM 3784 C C . LYS A 1 487 ? 34.989 12.208 -18.803 1.00 48.85 ? 515 LYS A C 1 ATOM 3785 O O . LYS A 1 487 ? 35.484 13.269 -19.188 1.00 49.12 ? 515 LYS A O 1 ATOM 3786 C CB . LYS A 1 487 ? 33.217 12.539 -20.626 1.00 48.35 ? 515 LYS A CB 1 ATOM 3787 C CG . LYS A 1 487 ? 32.431 11.909 -21.811 1.00 48.08 ? 515 LYS A CG 1 ATOM 3788 C CD . LYS A 1 487 ? 32.100 12.941 -22.878 0.010 47.87 ? 515 LYS A CD 1 ATOM 3789 C CE . LYS A 1 487 ? 31.504 12.289 -24.118 0.010 47.74 ? 515 LYS A CE 1 ATOM 3790 N NZ . LYS A 1 487 ? 31.156 13.295 -25.159 0.010 47.66 ? 515 LYS A NZ 1 ATOM 3791 N N . GLU A 1 488 ? 35.384 11.609 -17.672 1.00 49.22 ? 516 GLU A N 1 ATOM 3792 C CA . GLU A 1 488 ? 36.537 12.106 -16.872 1.00 49.80 ? 516 GLU A CA 1 ATOM 3793 C C . GLU A 1 488 ? 37.875 11.753 -17.583 1.00 49.36 ? 516 GLU A C 1 ATOM 3794 O O . GLU A 1 488 ? 37.900 10.862 -18.434 1.00 49.52 ? 516 GLU A O 1 ATOM 3795 C CB . GLU A 1 488 ? 36.513 11.551 -15.416 1.00 50.43 ? 516 GLU A CB 1 ATOM 3796 C CG . GLU A 1 488 ? 35.404 12.107 -14.433 1.00 53.72 ? 516 GLU A CG 1 ATOM 3797 C CD . GLU A 1 488 ? 35.226 11.302 -13.080 1.00 58.27 ? 516 GLU A CD 1 ATOM 3798 O OE1 . GLU A 1 488 ? 36.206 10.703 -12.550 1.00 59.53 ? 516 GLU A OE1 1 ATOM 3799 O OE2 . GLU A 1 488 ? 34.090 11.277 -12.531 1.00 59.07 ? 516 GLU A OE2 1 ATOM 3800 N N . ASP A 1 489 ? 38.970 12.450 -17.250 1.00 49.10 ? 517 ASP A N 1 ATOM 3801 C CA . ASP A 1 489 ? 40.303 12.163 -17.831 1.00 48.71 ? 517 ASP A CA 1 ATOM 3802 C C . ASP A 1 489 ? 40.839 10.820 -17.309 1.00 48.12 ? 517 ASP A C 1 ATOM 3803 O O . ASP A 1 489 ? 41.186 10.689 -16.123 1.00 47.96 ? 517 ASP A O 1 ATOM 3804 C CB . ASP A 1 489 ? 41.322 13.296 -17.558 1.00 48.92 ? 517 ASP A CB 1 ATOM 3805 C CG . ASP A 1 489 ? 42.759 12.940 -18.018 1.00 49.81 ? 517 ASP A CG 1 ATOM 3806 O OD1 . ASP A 1 489 ? 43.011 12.831 -19.240 1.00 50.41 ? 517 ASP A OD1 1 ATOM 3807 O OD2 . ASP A 1 489 ? 43.641 12.763 -17.153 1.00 50.45 ? 517 ASP A OD2 1 ATOM 3808 N N . ALA A 1 490 ? 40.904 9.841 -18.213 1.00 47.19 ? 518 ALA A N 1 ATOM 3809 C CA . ALA A 1 490 ? 41.244 8.465 -17.864 1.00 46.04 ? 518 ALA A CA 1 ATOM 3810 C C . ALA A 1 490 ? 42.720 8.136 -18.089 1.00 45.28 ? 518 ALA A C 1 ATOM 3811 O O . ALA A 1 490 ? 43.174 7.037 -17.750 1.00 45.24 ? 518 ALA A O 1 ATOM 3812 C CB . ALA A 1 490 ? 40.355 7.498 -18.638 1.00 45.91 ? 518 ALA A CB 1 ATOM 3813 N N . SER A 1 491 ? 43.473 9.094 -18.621 1.00 44.45 ? 519 SER A N 1 ATOM 3814 C CA . SER A 1 491 ? 44.814 8.798 -19.145 1.00 43.95 ? 519 SER A CA 1 ATOM 3815 C C . SER A 1 491 ? 45.850 8.216 -18.153 1.00 43.00 ? 519 SER A C 1 ATOM 3816 O O . SER A 1 491 ? 46.731 7.460 -18.567 1.00 43.37 ? 519 SER A O 1 ATOM 3817 C CB . SER A 1 491 ? 45.382 9.987 -19.943 1.00 43.86 ? 519 SER A CB 1 ATOM 3818 O OG . SER A 1 491 ? 46.043 10.896 -19.090 1.00 45.38 ? 519 SER A OG 1 ATOM 3819 N N . ALA A 1 492 ? 45.745 8.546 -16.869 1.00 41.97 ? 520 ALA A N 1 ATOM 3820 C CA . ALA A 1 492 ? 46.654 7.979 -15.859 1.00 41.06 ? 520 ALA A CA 1 ATOM 3821 C C . ALA A 1 492 ? 46.369 6.475 -15.599 1.00 40.42 ? 520 ALA A C 1 ATOM 3822 O O . ALA A 1 492 ? 47.285 5.659 -15.405 1.00 40.32 ? 520 ALA A O 1 ATOM 3823 C CB . ALA A 1 492 ? 46.596 8.787 -14.565 1.00 40.63 ? 520 ALA A CB 1 ATOM 3824 N N . LEU A 1 493 ? 45.093 6.125 -15.605 1.00 39.59 ? 521 LEU A N 1 ATOM 3825 C CA . LEU A 1 493 ? 44.651 4.744 -15.435 1.00 39.32 ? 521 LEU A CA 1 ATOM 3826 C C . LEU A 1 493 ? 45.031 3.876 -16.644 1.00 38.87 ? 521 LEU A C 1 ATOM 3827 O O . LEU A 1 493 ? 45.440 2.734 -16.482 1.00 38.86 ? 521 LEU A O 1 ATOM 3828 C CB . LEU A 1 493 ? 43.136 4.725 -15.227 1.00 39.19 ? 521 LEU A CB 1 ATOM 3829 C CG . LEU A 1 493 ? 42.452 3.540 -14.553 1.00 40.50 ? 521 LEU A CG 1 ATOM 3830 C CD1 . LEU A 1 493 ? 42.912 3.375 -13.104 1.00 42.25 ? 521 LEU A CD1 1 ATOM 3831 C CD2 . LEU A 1 493 ? 40.956 3.754 -14.593 1.00 40.76 ? 521 LEU A CD2 1 ATOM 3832 N N . ILE A 1 494 ? 44.877 4.432 -17.843 1.00 38.19 ? 522 ILE A N 1 ATOM 3833 C CA . ILE A 1 494 ? 45.275 3.784 -19.083 1.00 37.83 ? 522 ILE A CA 1 ATOM 3834 C C . ILE A 1 494 ? 46.774 3.400 -19.105 1.00 38.51 ? 522 ILE A C 1 ATOM 3835 O O . ILE A 1 494 ? 47.111 2.295 -19.516 1.00 38.69 ? 522 ILE A O 1 ATOM 3836 C CB . ILE A 1 494 ? 44.818 4.633 -20.315 1.00 37.49 ? 522 ILE A CB 1 ATOM 3837 C CG1 . ILE A 1 494 ? 43.286 4.665 -20.367 1.00 36.76 ? 522 ILE A CG1 1 ATOM 3838 C CG2 . ILE A 1 494 ? 45.367 4.090 -21.604 1.00 36.37 ? 522 ILE A CG2 1 ATOM 3839 C CD1 . ILE A 1 494 ? 42.679 5.518 -21.471 1.00 35.52 ? 522 ILE A CD1 1 ATOM 3840 N N . GLU A 1 495 ? 47.668 4.276 -18.646 1.00 39.31 ? 523 GLU A N 1 ATOM 3841 C CA . GLU A 1 495 ? 49.101 3.905 -18.556 1.00 40.56 ? 523 GLU A CA 1 ATOM 3842 C C . GLU A 1 495 ? 49.334 2.794 -17.517 1.00 40.28 ? 523 GLU A C 1 ATOM 3843 O O . GLU A 1 495 ? 50.060 1.820 -17.788 1.00 40.81 ? 523 GLU A O 1 ATOM 3844 C CB . GLU A 1 495 ? 50.024 5.121 -18.290 1.00 40.95 ? 523 GLU A CB 1 ATOM 3845 C CG . GLU A 1 495 ? 51.520 4.938 -18.763 1.00 44.51 ? 523 GLU A CG 1 ATOM 3846 C CD . GLU A 1 495 ? 51.716 4.840 -20.329 1.00 48.94 ? 523 GLU A CD 1 ATOM 3847 O OE1 . GLU A 1 495 ? 50.762 5.134 -21.100 1.00 49.11 ? 523 GLU A OE1 1 ATOM 3848 O OE2 . GLU A 1 495 ? 52.834 4.474 -20.792 1.00 49.97 ? 523 GLU A OE2 1 ATOM 3849 N N . GLU A 1 496 ? 48.698 2.944 -16.352 1.00 39.82 ? 524 GLU A N 1 ATOM 3850 C CA . GLU A 1 496 ? 48.722 1.961 -15.262 1.00 39.07 ? 524 GLU A CA 1 ATOM 3851 C C . GLU A 1 496 ? 48.317 0.582 -15.833 1.00 37.45 ? 524 GLU A C 1 ATOM 3852 O O . GLU A 1 496 ? 49.003 -0.420 -15.603 1.00 37.31 ? 524 GLU A O 1 ATOM 3853 C CB . GLU A 1 496 ? 47.773 2.422 -14.129 1.00 39.75 ? 524 GLU A CB 1 ATOM 3854 C CG . GLU A 1 496 ? 48.196 2.147 -12.654 1.00 43.58 ? 524 GLU A CG 1 ATOM 3855 C CD . GLU A 1 496 ? 47.402 3.006 -11.598 1.00 49.35 ? 524 GLU A CD 1 ATOM 3856 O OE1 . GLU A 1 496 ? 46.831 4.071 -11.959 1.00 51.47 ? 524 GLU A OE1 1 ATOM 3857 O OE2 . GLU A 1 496 ? 47.353 2.627 -10.396 1.00 50.99 ? 524 GLU A OE2 1 ATOM 3858 N N . LEU A 1 497 ? 47.236 0.557 -16.615 1.00 35.49 ? 525 LEU A N 1 ATOM 3859 C CA . LEU A 1 497 ? 46.695 -0.677 -17.193 1.00 33.80 ? 525 LEU A CA 1 ATOM 3860 C C . LEU A 1 497 ? 47.550 -1.304 -18.308 1.00 33.37 ? 525 LEU A C 1 ATOM 3861 O O . LEU A 1 497 ? 47.626 -2.524 -18.393 1.00 33.07 ? 525 LEU A O 1 ATOM 3862 C CB . LEU A 1 497 ? 45.246 -0.484 -17.657 1.00 33.24 ? 525 LEU A CB 1 ATOM 3863 C CG . LEU A 1 497 ? 44.095 -0.601 -16.650 1.00 32.60 ? 525 LEU A CG 1 ATOM 3864 C CD1 . LEU A 1 497 ? 42.742 -0.189 -17.240 1.00 31.54 ? 525 LEU A CD1 1 ATOM 3865 C CD2 . LEU A 1 497 ? 43.984 -1.997 -16.108 1.00 32.29 ? 525 LEU A CD2 1 ATOM 3866 N N . TYR A 1 498 ? 48.182 -0.487 -19.155 1.00 32.79 ? 526 TYR A N 1 ATOM 3867 C CA . TYR A 1 498 ? 49.149 -1.008 -20.132 1.00 32.34 ? 526 TYR A CA 1 ATOM 3868 C C . TYR A 1 498 ? 50.294 -1.748 -19.419 1.00 32.07 ? 526 TYR A C 1 ATOM 3869 O O . TYR A 1 498 ? 50.779 -2.767 -19.906 1.00 31.68 ? 526 TYR A O 1 ATOM 3870 C CB . TYR A 1 498 ? 49.750 0.110 -21.019 1.00 32.57 ? 526 TYR A CB 1 ATOM 3871 C CG . TYR A 1 498 ? 48.948 0.523 -22.243 1.00 32.58 ? 526 TYR A CG 1 ATOM 3872 C CD1 . TYR A 1 498 ? 48.566 -0.406 -23.214 1.00 33.16 ? 526 TYR A CD1 1 ATOM 3873 C CD2 . TYR A 1 498 ? 48.575 1.861 -22.434 1.00 33.78 ? 526 TYR A CD2 1 ATOM 3874 C CE1 . TYR A 1 498 ? 47.824 -0.009 -24.353 1.00 32.57 ? 526 TYR A CE1 1 ATOM 3875 C CE2 . TYR A 1 498 ? 47.835 2.266 -23.568 1.00 33.15 ? 526 TYR A CE2 1 ATOM 3876 C CZ . TYR A 1 498 ? 47.472 1.327 -24.517 1.00 32.59 ? 526 TYR A CZ 1 ATOM 3877 O OH . TYR A 1 498 ? 46.744 1.716 -25.608 1.00 32.03 ? 526 TYR A OH 1 ATOM 3878 N N . GLY A 1 499 ? 50.731 -1.213 -18.280 1.00 32.13 ? 527 GLY A N 1 ATOM 3879 C CA . GLY A 1 499 ? 51.768 -1.843 -17.461 1.00 32.34 ? 527 GLY A CA 1 ATOM 3880 C C . GLY A 1 499 ? 51.371 -3.227 -16.966 1.00 32.71 ? 527 GLY A C 1 ATOM 3881 O O . GLY A 1 499 ? 52.180 -4.143 -17.012 1.00 33.23 ? 527 GLY A O 1 ATOM 3882 N N . GLU A 1 500 ? 50.124 -3.375 -16.515 1.00 32.71 ? 528 GLU A N 1 ATOM 3883 C CA . GLU A 1 500 ? 49.602 -4.634 -15.985 1.00 33.42 ? 528 GLU A CA 1 ATOM 3884 C C . GLU A 1 500 ? 49.512 -5.705 -17.074 1.00 32.76 ? 528 GLU A C 1 ATOM 3885 O O . GLU A 1 500 ? 49.968 -6.842 -16.879 1.00 33.04 ? 528 GLU A O 1 ATOM 3886 C CB . GLU A 1 500 ? 48.236 -4.431 -15.302 1.00 33.98 ? 528 GLU A CB 1 ATOM 3887 C CG . GLU A 1 500 ? 48.292 -3.712 -13.921 1.00 38.67 ? 528 GLU A CG 1 ATOM 3888 C CD . GLU A 1 500 ? 48.347 -4.664 -12.681 1.00 44.94 ? 528 GLU A CD 1 ATOM 3889 O OE1 . GLU A 1 500 ? 47.356 -5.414 -12.432 1.00 47.04 ? 528 GLU A OE1 1 ATOM 3890 O OE2 . GLU A 1 500 ? 49.371 -4.638 -11.937 1.00 45.83 ? 528 GLU A OE2 1 ATOM 3891 N N . PHE A 1 501 ? 48.944 -5.336 -18.219 1.00 31.45 ? 529 PHE A N 1 ATOM 3892 C CA . PHE A 1 501 ? 48.885 -6.220 -19.379 1.00 30.05 ? 529 PHE A CA 1 ATOM 3893 C C . PHE A 1 501 ? 50.282 -6.613 -19.921 1.00 29.95 ? 529 PHE A C 1 ATOM 3894 O O . PHE A 1 501 ? 50.527 -7.778 -20.288 1.00 29.63 ? 529 PHE A O 1 ATOM 3895 C CB . PHE A 1 501 ? 48.010 -5.590 -20.465 1.00 29.46 ? 529 PHE A CB 1 ATOM 3896 C CG . PHE A 1 501 ? 46.625 -5.207 -19.995 1.00 28.29 ? 529 PHE A CG 1 ATOM 3897 C CD1 . PHE A 1 501 ? 45.963 -5.944 -19.002 1.00 27.56 ? 529 PHE A CD1 1 ATOM 3898 C CD2 . PHE A 1 501 ? 45.955 -4.132 -20.578 1.00 29.22 ? 529 PHE A CD2 1 ATOM 3899 C CE1 . PHE A 1 501 ? 44.671 -5.619 -18.571 1.00 25.16 ? 529 PHE A CE1 1 ATOM 3900 C CE2 . PHE A 1 501 ? 44.651 -3.791 -20.159 1.00 28.47 ? 529 PHE A CE2 1 ATOM 3901 C CZ . PHE A 1 501 ? 44.014 -4.554 -19.148 1.00 27.22 ? 529 PHE A CZ 1 ATOM 3902 N N . ALA A 1 502 ? 51.199 -5.651 -19.962 1.00 29.70 ? 530 ALA A N 1 ATOM 3903 C CA . ALA A 1 502 ? 52.583 -5.954 -20.339 1.00 30.07 ? 530 ALA A CA 1 ATOM 3904 C C . ALA A 1 502 ? 53.159 -6.959 -19.335 1.00 30.16 ? 530 ALA A C 1 ATOM 3905 O O . ALA A 1 502 ? 53.816 -7.932 -19.716 1.00 30.53 ? 530 ALA A O 1 ATOM 3906 C CB . ALA A 1 502 ? 53.440 -4.679 -20.387 1.00 29.29 ? 530 ALA A CB 1 ATOM 3907 N N . ARG A 1 503 ? 52.860 -6.731 -18.057 1.00 29.80 ? 531 ARG A N 1 ATOM 3908 C CA . ARG A 1 503 ? 53.422 -7.499 -16.960 1.00 29.73 ? 531 ARG A CA 1 ATOM 3909 C C . ARG A 1 503 ? 52.951 -8.959 -16.983 1.00 28.83 ? 531 ARG A C 1 ATOM 3910 O O . ARG A 1 503 ? 53.735 -9.873 -16.722 1.00 28.37 ? 531 ARG A O 1 ATOM 3911 C CB . ARG A 1 503 ? 53.065 -6.813 -15.633 1.00 30.14 ? 531 ARG A CB 1 ATOM 3912 C CG . ARG A 1 503 ? 53.557 -7.510 -14.375 1.00 34.45 ? 531 ARG A CG 1 ATOM 3913 C CD . ARG A 1 503 ? 55.090 -7.609 -14.318 1.00 40.22 ? 531 ARG A CD 1 ATOM 3914 N NE . ARG A 1 503 ? 55.528 -8.052 -12.990 1.00 43.64 ? 531 ARG A NE 1 ATOM 3915 C CZ . ARG A 1 503 ? 56.170 -9.193 -12.754 1.00 44.27 ? 531 ARG A CZ 1 ATOM 3916 N NH1 . ARG A 1 503 ? 56.473 -10.005 -13.766 1.00 43.82 ? 531 ARG A NH1 1 ATOM 3917 N NH2 . ARG A 1 503 ? 56.517 -9.505 -11.509 1.00 43.00 ? 531 ARG A NH2 1 ATOM 3918 N N . MET A 1 504 ? 51.675 -9.155 -17.309 1.00 27.95 ? 532 MET A N 1 ATOM 3919 C CA . MET A 1 504 ? 51.073 -10.467 -17.423 1.00 27.64 ? 532 MET A CA 1 ATOM 3920 C C . MET A 1 504 ? 51.801 -11.292 -18.478 1.00 28.19 ? 532 MET A C 1 ATOM 3921 O O . MET A 1 504 ? 52.133 -12.472 -18.270 1.00 28.17 ? 532 MET A O 1 ATOM 3922 C CB . MET A 1 504 ? 49.610 -10.321 -17.808 1.00 27.19 ? 532 MET A CB 1 ATOM 3923 C CG . MET A 1 504 ? 48.707 -9.913 -16.654 1.00 26.84 ? 532 MET A CG 1 ATOM 3924 S SD . MET A 1 504 ? 47.133 -9.246 -17.229 1.00 26.84 ? 532 MET A SD 1 ATOM 3925 C CE . MET A 1 504 ? 46.393 -10.637 -18.106 1.00 24.43 ? 532 MET A CE 1 ATOM 3926 N N . GLU A 1 505 ? 52.050 -10.646 -19.611 1.00 28.47 ? 533 GLU A N 1 ATOM 3927 C CA . GLU A 1 505 ? 52.761 -11.235 -20.713 1.00 28.68 ? 533 GLU A CA 1 ATOM 3928 C C . GLU A 1 505 ? 54.235 -11.511 -20.337 1.00 28.25 ? 533 GLU A C 1 ATOM 3929 O O . GLU A 1 505 ? 54.700 -12.635 -20.483 1.00 28.31 ? 533 GLU A O 1 ATOM 3930 C CB . GLU A 1 505 ? 52.589 -10.341 -21.939 1.00 29.02 ? 533 GLU A CB 1 ATOM 3931 C CG . GLU A 1 505 ? 53.353 -10.799 -23.164 1.00 33.41 ? 533 GLU A CG 1 ATOM 3932 C CD . GLU A 1 505 ? 52.931 -10.072 -24.436 1.00 37.21 ? 533 GLU A CD 1 ATOM 3933 O OE1 . GLU A 1 505 ? 52.208 -9.045 -24.339 1.00 37.85 ? 533 GLU A OE1 1 ATOM 3934 O OE2 . GLU A 1 505 ? 53.316 -10.559 -25.526 1.00 37.94 ? 533 GLU A OE2 1 ATOM 3935 N N . GLU A 1 506 ? 54.949 -10.510 -19.822 1.00 27.97 ? 534 GLU A N 1 ATOM 3936 C CA . GLU A 1 506 ? 56.332 -10.679 -19.332 1.00 27.99 ? 534 GLU A CA 1 ATOM 3937 C C . GLU A 1 506 ? 56.439 -11.877 -18.388 1.00 27.19 ? 534 GLU A C 1 ATOM 3938 O O . GLU A 1 506 ? 57.295 -12.735 -18.583 1.00 27.49 ? 534 GLU A O 1 ATOM 3939 C CB . GLU A 1 506 ? 56.802 -9.398 -18.615 1.00 28.52 ? 534 GLU A CB 1 ATOM 3940 C CG . GLU A 1 506 ? 58.296 -9.290 -18.194 1.00 32.91 ? 534 GLU A CG 1 ATOM 3941 C CD . GLU A 1 506 ? 58.704 -10.182 -16.994 1.00 40.07 ? 534 GLU A CD 1 ATOM 3942 O OE1 . GLU A 1 506 ? 57.940 -10.258 -15.989 1.00 43.16 ? 534 GLU A OE1 1 ATOM 3943 O OE2 . GLU A 1 506 ? 59.803 -10.809 -17.055 1.00 41.43 ? 534 GLU A OE2 1 ATOM 3944 N N . ALA A 1 507 ? 55.568 -11.928 -17.375 1.00 26.23 ? 535 ALA A N 1 ATOM 3945 C CA . ALA A 1 507 ? 55.583 -12.991 -16.362 1.00 25.06 ? 535 ALA A CA 1 ATOM 3946 C C . ALA A 1 507 ? 55.327 -14.370 -16.962 1.00 24.35 ? 535 ALA A C 1 ATOM 3947 O O . ALA A 1 507 ? 56.050 -15.327 -16.673 1.00 24.26 ? 535 ALA A O 1 ATOM 3948 C CB . ALA A 1 507 ? 54.560 -12.703 -15.273 1.00 24.73 ? 535 ALA A CB 1 ATOM 3949 N N . CYS A 1 508 ? 54.298 -14.477 -17.794 1.00 23.45 ? 536 CYS A N 1 ATOM 3950 C CA . CYS A 1 508 ? 53.978 -15.758 -18.406 1.00 22.96 ? 536 CYS A CA 1 ATOM 3951 C C . CYS A 1 508 ? 55.083 -16.284 -19.334 1.00 23.40 ? 536 CYS A C 1 ATOM 3952 O O . CYS A 1 508 ? 55.360 -17.485 -19.349 1.00 22.80 ? 536 CYS A O 1 ATOM 3953 C CB . CYS A 1 508 ? 52.650 -15.691 -19.131 1.00 22.81 ? 536 CYS A CB 1 ATOM 3954 S SG . CYS A 1 508 ? 51.248 -15.626 -18.020 1.00 20.93 ? 536 CYS A SG 1 ATOM 3955 N N . ASN A 1 509 ? 55.718 -15.386 -20.089 1.00 23.81 ? 537 ASN A N 1 ATOM 3956 C CA . ASN A 1 509 ? 56.863 -15.765 -20.925 1.00 24.61 ? 537 ASN A CA 1 ATOM 3957 C C . ASN A 1 509 ? 58.041 -16.262 -20.064 1.00 24.76 ? 537 ASN A C 1 ATOM 3958 O O . ASN A 1 509 ? 58.716 -17.252 -20.405 1.00 24.03 ? 537 ASN A O 1 ATOM 3959 C CB . ASN A 1 509 ? 57.284 -14.619 -21.878 1.00 24.64 ? 537 ASN A CB 1 ATOM 3960 C CG . ASN A 1 509 ? 56.369 -14.507 -23.133 1.00 25.82 ? 537 ASN A CG 1 ATOM 3961 O OD1 . ASN A 1 509 ? 56.003 -15.510 -23.786 1.00 27.16 ? 537 ASN A OD1 1 ATOM 3962 N ND2 . ASN A 1 509 ? 56.020 -13.283 -23.473 1.00 26.73 ? 537 ASN A ND2 1 ATOM 3963 N N . ASN A 1 510 ? 58.259 -15.588 -18.933 1.00 24.88 ? 538 ASN A N 1 ATOM 3964 C CA . ASN A 1 510 ? 59.279 -16.021 -17.987 1.00 25.10 ? 538 ASN A CA 1 ATOM 3965 C C . ASN A 1 510 ? 58.999 -17.425 -17.399 1.00 25.00 ? 538 ASN A C 1 ATOM 3966 O O . ASN A 1 510 ? 59.914 -18.253 -17.284 1.00 24.96 ? 538 ASN A O 1 ATOM 3967 C CB . ASN A 1 510 ? 59.461 -14.998 -16.882 1.00 24.89 ? 538 ASN A CB 1 ATOM 3968 C CG . ASN A 1 510 ? 60.693 -15.263 -16.062 1.00 27.05 ? 538 ASN A CG 1 ATOM 3969 O OD1 . ASN A 1 510 ? 61.786 -15.510 -16.600 1.00 29.29 ? 538 ASN A OD1 1 ATOM 3970 N ND2 . ASN A 1 510 ? 60.534 -15.232 -14.747 1.00 27.47 ? 538 ASN A ND2 1 ATOM 3971 N N . LEU A 1 511 ? 57.739 -17.699 -17.047 1.00 24.69 ? 539 LEU A N 1 ATOM 3972 C CA . LEU A 1 511 ? 57.372 -19.024 -16.525 1.00 24.17 ? 539 LEU A CA 1 ATOM 3973 C C . LEU A 1 511 ? 57.597 -20.105 -17.574 1.00 24.44 ? 539 LEU A C 1 ATOM 3974 O O . LEU A 1 511 ? 58.199 -21.133 -17.267 1.00 24.60 ? 539 LEU A O 1 ATOM 3975 C CB . LEU A 1 511 ? 55.944 -19.049 -15.956 1.00 23.55 ? 539 LEU A CB 1 ATOM 3976 C CG . LEU A 1 511 ? 55.681 -18.099 -14.767 1.00 23.05 ? 539 LEU A CG 1 ATOM 3977 C CD1 . LEU A 1 511 ? 54.192 -17.852 -14.550 1.00 20.68 ? 539 LEU A CD1 1 ATOM 3978 C CD2 . LEU A 1 511 ? 56.330 -18.573 -13.467 1.00 20.49 ? 539 LEU A CD2 1 ATOM 3979 N N . LYS A 1 512 ? 57.161 -19.855 -18.810 1.00 24.76 ? 540 LYS A N 1 ATOM 3980 C CA . LYS A 1 512 ? 57.337 -20.799 -19.929 1.00 25.02 ? 540 LYS A CA 1 ATOM 3981 C C . LYS A 1 512 ? 58.792 -21.148 -20.154 1.00 25.43 ? 540 LYS A C 1 ATOM 3982 O O . LYS A 1 512 ? 59.123 -22.266 -20.554 1.00 25.89 ? 540 LYS A O 1 ATOM 3983 C CB . LYS A 1 512 ? 56.787 -20.215 -21.232 1.00 24.90 ? 540 LYS A CB 1 ATOM 3984 C CG . LYS A 1 512 ? 55.299 -20.427 -21.440 1.00 26.10 ? 540 LYS A CG 1 ATOM 3985 C CD . LYS A 1 512 ? 54.772 -19.673 -22.658 1.00 28.05 ? 540 LYS A CD 1 ATOM 3986 C CE . LYS A 1 512 ? 55.480 -20.085 -23.959 1.00 30.46 ? 540 LYS A CE 1 ATOM 3987 N NZ . LYS A 1 512 ? 54.875 -21.291 -24.603 1.00 31.22 ? 540 LYS A NZ 1 ATOM 3988 N N . ALA A 1 513 ? 59.663 -20.184 -19.906 1.00 25.54 ? 541 ALA A N 1 ATOM 3989 C CA . ALA A 1 513 ? 61.059 -20.386 -20.147 1.00 26.27 ? 541 ALA A CA 1 ATOM 3990 C C . ALA A 1 513 ? 61.712 -21.091 -18.977 1.00 27.00 ? 541 ALA A C 1 ATOM 3991 O O . ALA A 1 513 ? 62.578 -21.935 -19.198 1.00 27.85 ? 541 ALA A O 1 ATOM 3992 C CB . ALA A 1 513 ? 61.751 -19.049 -20.422 1.00 26.33 ? 541 ALA A CB 1 ATOM 3993 N N . ASN A 1 514 ? 61.289 -20.764 -17.749 1.00 27.16 ? 542 ASN A N 1 ATOM 3994 C CA . ASN A 1 514 ? 62.032 -21.157 -16.529 1.00 27.22 ? 542 ASN A CA 1 ATOM 3995 C C . ASN A 1 514 ? 61.407 -22.177 -15.553 1.00 26.61 ? 542 ASN A C 1 ATOM 3996 O O . ASN A 1 514 ? 62.115 -22.747 -14.734 1.00 26.50 ? 542 ASN A O 1 ATOM 3997 C CB . ASN A 1 514 ? 62.496 -19.906 -15.770 1.00 27.67 ? 542 ASN A CB 1 ATOM 3998 C CG . ASN A 1 514 ? 63.547 -19.098 -16.556 1.00 30.10 ? 542 ASN A CG 1 ATOM 3999 O OD1 . ASN A 1 514 ? 64.572 -19.639 -16.988 1.00 32.45 ? 542 ASN A OD1 1 ATOM 4000 N ND2 . ASN A 1 514 ? 63.287 -17.802 -16.744 1.00 29.70 ? 542 ASN A ND2 1 ATOM 4001 N N . LEU A 1 515 ? 60.100 -22.414 -15.631 1.00 25.93 ? 543 LEU A N 1 ATOM 4002 C CA . LEU A 1 515 ? 59.467 -23.448 -14.801 1.00 24.92 ? 543 LEU A CA 1 ATOM 4003 C C . LEU A 1 515 ? 60.065 -24.839 -15.096 1.00 24.44 ? 543 LEU A C 1 ATOM 4004 O O . LEU A 1 515 ? 60.302 -25.160 -16.258 1.00 24.46 ? 543 LEU A O 1 ATOM 4005 C CB . LEU A 1 515 ? 57.946 -23.475 -15.025 1.00 24.61 ? 543 LEU A CB 1 ATOM 4006 C CG . LEU A 1 515 ? 57.055 -22.484 -14.281 1.00 23.54 ? 543 LEU A CG 1 ATOM 4007 C CD1 . LEU A 1 515 ? 55.640 -22.692 -14.729 1.00 22.93 ? 543 LEU A CD1 1 ATOM 4008 C CD2 . LEU A 1 515 ? 57.171 -22.679 -12.789 1.00 22.28 ? 543 LEU A CD2 1 ATOM 4009 N N . PRO A 1 516 ? 60.329 -25.655 -14.044 1.00 24.14 ? 544 PRO A N 1 ATOM 4010 C CA . PRO A 1 516 ? 60.677 -27.072 -14.243 1.00 23.34 ? 544 PRO A CA 1 ATOM 4011 C C . PRO A 1 516 ? 59.578 -27.873 -14.963 1.00 22.99 ? 544 PRO A C 1 ATOM 4012 O O . PRO A 1 516 ? 58.405 -27.514 -14.863 1.00 23.07 ? 544 PRO A O 1 ATOM 4013 C CB . PRO A 1 516 ? 60.854 -27.605 -12.806 1.00 23.38 ? 544 PRO A CB 1 ATOM 4014 C CG . PRO A 1 516 ? 60.342 -26.513 -11.888 1.00 24.38 ? 544 PRO A CG 1 ATOM 4015 C CD . PRO A 1 516 ? 60.538 -25.237 -12.638 1.00 24.17 ? 544 PRO A CD 1 ATOM 4016 N N . GLU A 1 517 ? 59.944 -28.962 -15.644 1.00 22.24 ? 545 GLU A N 1 ATOM 4017 C CA . GLU A 1 517 ? 58.969 -29.766 -16.373 1.00 22.18 ? 545 GLU A CA 1 ATOM 4018 C C . GLU A 1 517 ? 57.724 -30.073 -15.541 1.00 21.66 ? 545 GLU A C 1 ATOM 4019 O O . GLU A 1 517 ? 56.591 -29.869 -16.000 1.00 21.66 ? 545 GLU A O 1 ATOM 4020 C CB . GLU A 1 517 ? 59.577 -31.067 -16.939 1.00 22.33 ? 545 GLU A CB 1 ATOM 4021 C CG . GLU A 1 517 ? 58.684 -31.699 -18.019 1.00 23.79 ? 545 GLU A CG 1 ATOM 4022 C CD . GLU A 1 517 ? 59.176 -33.032 -18.549 1.00 26.30 ? 545 GLU A CD 1 ATOM 4023 O OE1 . GLU A 1 517 ? 60.317 -33.044 -19.060 1.00 21.54 ? 545 GLU A OE1 1 ATOM 4024 O OE2 . GLU A 1 517 ? 58.416 -34.066 -18.456 1.00 29.84 ? 545 GLU A OE2 1 ATOM 4025 N N . VAL A 1 518 ? 57.942 -30.541 -14.313 1.00 21.06 ? 546 VAL A N 1 ATOM 4026 C CA . VAL A 1 518 ? 56.862 -31.020 -13.440 1.00 19.90 ? 546 VAL A CA 1 ATOM 4027 C C . VAL A 1 518 ? 55.734 -29.980 -13.231 1.00 19.68 ? 546 VAL A C 1 ATOM 4028 O O . VAL A 1 518 ? 54.556 -30.338 -13.194 1.00 18.82 ? 546 VAL A O 1 ATOM 4029 C CB . VAL A 1 518 ? 57.443 -31.627 -12.095 1.00 20.21 ? 546 VAL A CB 1 ATOM 4030 C CG1 . VAL A 1 518 ? 58.050 -30.539 -11.179 1.00 19.09 ? 546 VAL A CG1 1 ATOM 4031 C CG2 . VAL A 1 518 ? 56.396 -32.508 -11.357 1.00 18.47 ? 546 VAL A CG2 1 ATOM 4032 N N . ALA A 1 519 ? 56.089 -28.700 -13.125 1.00 19.31 ? 547 ALA A N 1 ATOM 4033 C CA . ALA A 1 519 ? 55.079 -27.648 -13.113 1.00 19.47 ? 547 ALA A CA 1 ATOM 4034 C C . ALA A 1 519 ? 54.643 -27.295 -14.534 1.00 20.33 ? 547 ALA A C 1 ATOM 4035 O O . ALA A 1 519 ? 53.431 -27.259 -14.845 1.00 20.02 ? 547 ALA A O 1 ATOM 4036 C CB . ALA A 1 519 ? 55.568 -26.432 -12.391 1.00 19.32 ? 547 ALA A CB 1 ATOM 4037 N N . LEU A 1 520 ? 55.619 -27.069 -15.409 1.00 20.92 ? 548 LEU A N 1 ATOM 4038 C CA . LEU A 1 520 ? 55.319 -26.606 -16.773 1.00 21.69 ? 548 LEU A CA 1 ATOM 4039 C C . LEU A 1 520 ? 54.331 -27.486 -17.540 1.00 22.54 ? 548 LEU A C 1 ATOM 4040 O O . LEU A 1 520 ? 53.404 -26.976 -18.140 1.00 23.90 ? 548 LEU A O 1 ATOM 4041 C CB . LEU A 1 520 ? 56.594 -26.361 -17.577 1.00 21.49 ? 548 LEU A CB 1 ATOM 4042 C CG . LEU A 1 520 ? 56.412 -25.705 -18.948 1.00 21.98 ? 548 LEU A CG 1 ATOM 4043 C CD1 . LEU A 1 520 ? 56.004 -24.246 -18.851 1.00 21.99 ? 548 LEU A CD1 1 ATOM 4044 C CD2 . LEU A 1 520 ? 57.678 -25.853 -19.725 1.00 21.18 ? 548 LEU A CD2 1 ATOM 4045 N N . GLU A 1 521 ? 54.481 -28.806 -17.484 1.00 23.70 ? 549 GLU A N 1 ATOM 4046 C CA . GLU A 1 521 ? 53.583 -29.736 -18.214 1.00 23.57 ? 549 GLU A CA 1 ATOM 4047 C C . GLU A 1 521 ? 52.170 -29.769 -17.675 1.00 23.09 ? 549 GLU A C 1 ATOM 4048 O O . GLU A 1 521 ? 51.310 -30.478 -18.191 1.00 23.28 ? 549 GLU A O 1 ATOM 4049 C CB . GLU A 1 521 ? 54.151 -31.156 -18.207 1.00 23.94 ? 549 GLU A CB 1 ATOM 4050 C CG . GLU A 1 521 ? 54.328 -31.739 -16.834 1.00 26.53 ? 549 GLU A CG 1 ATOM 4051 C CD . GLU A 1 521 ? 55.147 -33.016 -16.811 1.00 30.82 ? 549 GLU A CD 1 ATOM 4052 O OE1 . GLU A 1 521 ? 55.779 -33.382 -17.839 1.00 33.67 ? 549 GLU A OE1 1 ATOM 4053 O OE2 . GLU A 1 521 ? 55.170 -33.659 -15.731 1.00 33.74 ? 549 GLU A OE2 1 ATOM 4054 N N . GLU A 1 522 ? 51.932 -29.020 -16.610 1.00 23.19 ? 550 GLU A N 1 ATOM 4055 C CA . GLU A 1 522 ? 50.592 -28.930 -16.033 1.00 22.55 ? 550 GLU A CA 1 ATOM 4056 C C . GLU A 1 522 ? 49.874 -27.623 -16.398 1.00 22.12 ? 550 GLU A C 1 ATOM 4057 O O . GLU A 1 522 ? 48.662 -27.604 -16.456 1.00 22.33 ? 550 GLU A O 1 ATOM 4058 C CB . GLU A 1 522 ? 50.636 -29.144 -14.517 1.00 22.30 ? 550 GLU A CB 1 ATOM 4059 C CG . GLU A 1 522 ? 51.004 -30.567 -14.123 1.00 21.76 ? 550 GLU A CG 1 ATOM 4060 C CD . GLU A 1 522 ? 50.739 -30.898 -12.649 1.00 22.37 ? 550 GLU A CD 1 ATOM 4061 O OE1 . GLU A 1 522 ? 50.326 -29.993 -11.886 1.00 21.78 ? 550 GLU A OE1 1 ATOM 4062 O OE2 . GLU A 1 522 ? 50.958 -32.070 -12.253 1.00 21.29 ? 550 GLU A OE2 1 ATOM 4063 N N . CYS A 1 523 ? 50.623 -26.562 -16.689 1.00 21.86 ? 551 CYS A N 1 ATOM 4064 C CA . CYS A 1 523 ? 50.044 -25.238 -16.886 1.00 21.49 ? 551 CYS A CA 1 ATOM 4065 C C . CYS A 1 523 ? 50.432 -24.558 -18.208 1.00 22.01 ? 551 CYS A C 1 ATOM 4066 O O . CYS A 1 523 ? 50.049 -23.407 -18.446 1.00 21.88 ? 551 CYS A O 1 ATOM 4067 C CB . CYS A 1 523 ? 50.420 -24.334 -15.715 1.00 21.01 ? 551 CYS A CB 1 ATOM 4068 S SG . CYS A 1 523 ? 52.182 -24.027 -15.508 1.00 20.17 ? 551 CYS A SG 1 ATOM 4069 N N . SER A 1 524 ? 51.167 -25.263 -19.072 1.00 22.45 ? 552 SER A N 1 ATOM 4070 C CA . SER A 1 524 ? 51.679 -24.643 -20.309 1.00 22.96 ? 552 SER A CA 1 ATOM 4071 C C . SER A 1 524 ? 50.600 -24.071 -21.241 1.00 22.81 ? 552 SER A C 1 ATOM 4072 O O . SER A 1 524 ? 50.799 -23.015 -21.826 1.00 22.39 ? 552 SER A O 1 ATOM 4073 C CB . SER A 1 524 ? 52.594 -25.582 -21.076 1.00 22.57 ? 552 SER A CB 1 ATOM 4074 O OG . SER A 1 524 ? 51.822 -26.533 -21.753 1.00 24.12 ? 552 SER A OG 1 ATOM 4075 N N . ARG A 1 525 ? 49.464 -24.755 -21.350 1.00 23.52 ? 553 ARG A N 1 ATOM 4076 C CA . ARG A 1 525 ? 48.349 -24.285 -22.207 1.00 24.57 ? 553 ARG A CA 1 ATOM 4077 C C . ARG A 1 525 ? 47.624 -23.074 -21.622 1.00 24.19 ? 553 ARG A C 1 ATOM 4078 O O . ARG A 1 525 ? 47.129 -22.213 -22.363 1.00 25.13 ? 553 ARG A O 1 ATOM 4079 C CB . ARG A 1 525 ? 47.358 -25.419 -22.518 1.00 24.85 ? 553 ARG A CB 1 ATOM 4080 C CG . ARG A 1 525 ? 47.962 -26.537 -23.367 1.00 29.05 ? 553 ARG A CG 1 ATOM 4081 C CD . ARG A 1 525 ? 47.066 -27.776 -23.422 1.00 38.44 ? 553 ARG A CD 1 ATOM 4082 N NE . ARG A 1 525 ? 46.895 -28.442 -22.108 1.00 42.93 ? 553 ARG A NE 1 ATOM 4083 C CZ . ARG A 1 525 ? 46.118 -29.510 -21.875 1.00 42.82 ? 553 ARG A CZ 1 ATOM 4084 N NH1 . ARG A 1 525 ? 45.410 -30.072 -22.858 1.00 42.67 ? 553 ARG A NH1 1 ATOM 4085 N NH2 . ARG A 1 525 ? 46.047 -30.014 -20.644 1.00 42.47 ? 553 ARG A NH2 1 ATOM 4086 N N . GLN A 1 526 ? 47.579 -23.007 -20.295 1.00 23.47 ? 554 GLN A N 1 ATOM 4087 C CA . GLN A 1 526 ? 46.991 -21.881 -19.592 1.00 22.75 ? 554 GLN A CA 1 ATOM 4088 C C . GLN A 1 526 ? 47.907 -20.640 -19.612 1.00 22.88 ? 554 GLN A C 1 ATOM 4089 O O . GLN A 1 526 ? 47.413 -19.511 -19.688 1.00 22.39 ? 554 GLN A O 1 ATOM 4090 C CB . GLN A 1 526 ? 46.608 -22.285 -18.157 1.00 22.56 ? 554 GLN A CB 1 ATOM 4091 C CG . GLN A 1 526 ? 45.406 -23.217 -18.065 1.00 21.72 ? 554 GLN A CG 1 ATOM 4092 C CD . GLN A 1 526 ? 45.723 -24.686 -18.369 1.00 21.10 ? 554 GLN A CD 1 ATOM 4093 O OE1 . GLN A 1 526 ? 46.878 -25.078 -18.564 1.00 20.44 ? 554 GLN A OE1 1 ATOM 4094 N NE2 . GLN A 1 526 ? 44.686 -25.500 -18.410 1.00 21.18 ? 554 GLN A NE2 1 ATOM 4095 N N . LEU A 1 527 ? 49.223 -20.848 -19.532 1.00 22.92 ? 555 LEU A N 1 ATOM 4096 C CA . LEU A 1 527 ? 50.190 -19.762 -19.766 1.00 23.55 ? 555 LEU A CA 1 ATOM 4097 C C . LEU A 1 527 ? 49.957 -19.130 -21.143 1.00 24.17 ? 555 LEU A C 1 ATOM 4098 O O . LEU A 1 527 ? 49.778 -17.912 -21.235 1.00 24.20 ? 555 LEU A O 1 ATOM 4099 C CB . LEU A 1 527 ? 51.643 -20.249 -19.636 1.00 22.96 ? 555 LEU A CB 1 ATOM 4100 C CG . LEU A 1 527 ? 52.090 -20.676 -18.223 1.00 23.00 ? 555 LEU A CG 1 ATOM 4101 C CD1 . LEU A 1 527 ? 53.445 -21.372 -18.229 1.00 19.99 ? 555 LEU A CD1 1 ATOM 4102 C CD2 . LEU A 1 527 ? 52.124 -19.471 -17.316 1.00 21.77 ? 555 LEU A CD2 1 ATOM 4103 N N . ASP A 1 528 ? 49.921 -19.963 -22.194 1.00 24.47 ? 556 ASP A N 1 ATOM 4104 C CA . ASP A 1 528 ? 49.651 -19.501 -23.565 1.00 25.16 ? 556 ASP A CA 1 ATOM 4105 C C . ASP A 1 528 ? 48.350 -18.679 -23.646 1.00 24.62 ? 556 ASP A C 1 ATOM 4106 O O . ASP A 1 528 ? 48.314 -17.637 -24.311 1.00 24.17 ? 556 ASP A O 1 ATOM 4107 C CB . ASP A 1 528 ? 49.611 -20.669 -24.572 1.00 25.36 ? 556 ASP A CB 1 ATOM 4108 C CG . ASP A 1 528 ? 50.995 -21.288 -24.829 1.00 28.45 ? 556 ASP A CG 1 ATOM 4109 O OD1 . ASP A 1 528 ? 52.038 -20.680 -24.470 1.00 31.76 ? 556 ASP A OD1 1 ATOM 4110 O OD2 . ASP A 1 528 ? 51.044 -22.404 -25.389 1.00 31.37 ? 556 ASP A OD2 1 ATOM 4111 N N . GLU A 1 529 ? 47.312 -19.155 -22.954 1.00 24.30 ? 557 GLU A N 1 ATOM 4112 C CA . GLU A 1 529 ? 46.008 -18.496 -22.877 1.00 24.26 ? 557 GLU A CA 1 ATOM 4113 C C . GLU A 1 529 ? 46.068 -17.096 -22.228 1.00 23.69 ? 557 GLU A C 1 ATOM 4114 O O . GLU A 1 529 ? 45.510 -16.139 -22.764 1.00 24.35 ? 557 GLU A O 1 ATOM 4115 C CB . GLU A 1 529 ? 45.028 -19.396 -22.136 1.00 24.49 ? 557 GLU A CB 1 ATOM 4116 C CG . GLU A 1 529 ? 43.592 -18.901 -22.117 1.00 27.41 ? 557 GLU A CG 1 ATOM 4117 C CD . GLU A 1 529 ? 42.814 -19.263 -23.363 1.00 31.05 ? 557 GLU A CD 1 ATOM 4118 O OE1 . GLU A 1 529 ? 43.467 -19.545 -24.405 1.00 33.04 ? 557 GLU A OE1 1 ATOM 4119 O OE2 . GLU A 1 529 ? 41.548 -19.268 -23.302 1.00 31.59 ? 557 GLU A OE2 1 ATOM 4120 N N . LEU A 1 530 ? 46.760 -16.962 -21.106 1.00 22.11 ? 558 LEU A N 1 ATOM 4121 C CA . LEU A 1 530 ? 46.859 -15.667 -20.454 1.00 21.21 ? 558 LEU A CA 1 ATOM 4122 C C . LEU A 1 530 ? 47.709 -14.660 -21.265 1.00 21.02 ? 558 LEU A C 1 ATOM 4123 O O . LEU A 1 530 ? 47.452 -13.466 -21.247 1.00 21.30 ? 558 LEU A O 1 ATOM 4124 C CB . LEU A 1 530 ? 47.354 -15.828 -19.006 1.00 20.71 ? 558 LEU A CB 1 ATOM 4125 C CG . LEU A 1 530 ? 47.244 -14.582 -18.134 1.00 20.85 ? 558 LEU A CG 1 ATOM 4126 C CD1 . LEU A 1 530 ? 45.785 -14.319 -17.858 1.00 20.29 ? 558 LEU A CD1 1 ATOM 4127 C CD2 . LEU A 1 530 ? 48.035 -14.734 -16.847 1.00 19.57 ? 558 LEU A CD2 1 ATOM 4128 N N . ILE A 1 531 ? 48.710 -15.135 -21.986 1.00 20.86 ? 559 ILE A N 1 ATOM 4129 C CA . ILE A 1 531 ? 49.464 -14.268 -22.880 1.00 20.89 ? 559 ILE A CA 1 ATOM 4130 C C . ILE A 1 531 ? 48.554 -13.759 -24.005 1.00 21.50 ? 559 ILE A C 1 ATOM 4131 O O . ILE A 1 531 ? 48.550 -12.562 -24.345 1.00 22.03 ? 559 ILE A O 1 ATOM 4132 C CB . ILE A 1 531 ? 50.654 -15.019 -23.468 1.00 20.69 ? 559 ILE A CB 1 ATOM 4133 C CG1 . ILE A 1 531 ? 51.644 -15.354 -22.349 1.00 20.77 ? 559 ILE A CG1 1 ATOM 4134 C CG2 . ILE A 1 531 ? 51.325 -14.219 -24.603 1.00 20.87 ? 559 ILE A CG2 1 ATOM 4135 C CD1 . ILE A 1 531 ? 52.736 -16.377 -22.731 1.00 18.70 ? 559 ILE A CD1 1 ATOM 4136 N N . THR A 1 532 ? 47.771 -14.664 -24.581 1.00 21.32 ? 560 THR A N 1 ATOM 4137 C CA . THR A 1 532 ? 46.815 -14.279 -25.604 1.00 21.25 ? 560 THR A CA 1 ATOM 4138 C C . THR A 1 532 ? 45.856 -13.177 -25.072 1.00 21.86 ? 560 THR A C 1 ATOM 4139 O O . THR A 1 532 ? 45.725 -12.100 -25.691 1.00 22.14 ? 560 THR A O 1 ATOM 4140 C CB . THR A 1 532 ? 46.085 -15.521 -26.126 1.00 21.02 ? 560 THR A CB 1 ATOM 4141 O OG1 . THR A 1 532 ? 47.022 -16.352 -26.826 1.00 20.43 ? 560 THR A OG1 1 ATOM 4142 C CG2 . THR A 1 532 ? 44.980 -15.146 -27.053 1.00 20.38 ? 560 THR A CG2 1 ATOM 4143 N N . LEU A 1 533 ? 45.249 -13.420 -23.903 1.00 21.37 ? 561 LEU A N 1 ATOM 4144 C CA . LEU A 1 533 ? 44.324 -12.465 -23.319 1.00 21.07 ? 561 LEU A CA 1 ATOM 4145 C C . LEU A 1 533 ? 44.993 -11.146 -22.981 1.00 21.56 ? 561 LEU A C 1 ATOM 4146 O O . LEU A 1 533 ? 44.413 -10.083 -23.203 1.00 20.93 ? 561 LEU A O 1 ATOM 4147 C CB . LEU A 1 533 ? 43.619 -13.045 -22.100 1.00 20.68 ? 561 LEU A CB 1 ATOM 4148 C CG . LEU A 1 533 ? 42.684 -14.204 -22.439 1.00 20.53 ? 561 LEU A CG 1 ATOM 4149 C CD1 . LEU A 1 533 ? 42.199 -14.843 -21.157 1.00 20.31 ? 561 LEU A CD1 1 ATOM 4150 C CD2 . LEU A 1 533 ? 41.514 -13.768 -23.320 1.00 18.50 ? 561 LEU A CD2 1 ATOM 4151 N N . ALA A 1 534 ? 46.215 -11.204 -22.462 1.00 22.29 ? 562 ALA A N 1 ATOM 4152 C CA . ALA A 1 534 ? 46.932 -9.973 -22.159 1.00 22.88 ? 562 ALA A CA 1 ATOM 4153 C C . ALA A 1 534 ? 47.089 -9.165 -23.431 1.00 23.34 ? 562 ALA A C 1 ATOM 4154 O O . ALA A 1 534 ? 46.862 -7.960 -23.426 1.00 23.95 ? 562 ALA A O 1 ATOM 4155 C CB . ALA A 1 534 ? 48.282 -10.256 -21.532 1.00 22.93 ? 562 ALA A CB 1 ATOM 4156 N N . GLN A 1 535 ? 47.441 -9.834 -24.525 1.00 23.74 ? 563 GLN A N 1 ATOM 4157 C CA . GLN A 1 535 ? 47.622 -9.156 -25.808 1.00 24.49 ? 563 GLN A CA 1 ATOM 4158 C C . GLN A 1 535 ? 46.311 -8.553 -26.274 1.00 25.08 ? 563 GLN A C 1 ATOM 4159 O O . GLN A 1 535 ? 46.306 -7.485 -26.883 1.00 26.16 ? 563 GLN A O 1 ATOM 4160 C CB . GLN A 1 535 ? 48.148 -10.112 -26.877 1.00 24.21 ? 563 GLN A CB 1 ATOM 4161 C CG . GLN A 1 535 ? 49.580 -10.528 -26.658 1.00 24.76 ? 563 GLN A CG 1 ATOM 4162 C CD . GLN A 1 535 ? 50.093 -11.420 -27.761 1.00 26.76 ? 563 GLN A CD 1 ATOM 4163 O OE1 . GLN A 1 535 ? 49.349 -12.195 -28.357 1.00 27.47 ? 563 GLN A OE1 1 ATOM 4164 N NE2 . GLN A 1 535 ? 51.374 -11.306 -28.050 1.00 28.33 ? 563 GLN A NE2 1 ATOM 4165 N N . GLY A 1 536 ? 45.209 -9.240 -25.996 1.00 24.70 ? 564 GLY A N 1 ATOM 4166 C CA . GLY A 1 536 ? 43.887 -8.744 -26.347 1.00 24.62 ? 564 GLY A CA 1 ATOM 4167 C C . GLY A 1 536 ? 43.393 -7.605 -25.475 1.00 24.55 ? 564 GLY A C 1 ATOM 4168 O O . GLY A 1 536 ? 42.657 -6.747 -25.943 1.00 24.83 ? 564 GLY A O 1 ATOM 4169 N N . ASP A 1 537 ? 43.764 -7.616 -24.198 1.00 23.98 ? 565 ASP A N 1 ATOM 4170 C CA . ASP A 1 537 ? 43.521 -6.490 -23.330 1.00 23.44 ? 565 ASP A CA 1 ATOM 4171 C C . ASP A 1 537 ? 44.293 -5.268 -23.862 1.00 23.52 ? 565 ASP A C 1 ATOM 4172 O O . ASP A 1 537 ? 43.738 -4.171 -23.946 1.00 23.39 ? 565 ASP A O 1 ATOM 4173 C CB . ASP A 1 537 ? 43.970 -6.791 -21.890 1.00 23.70 ? 565 ASP A CB 1 ATOM 4174 C CG . ASP A 1 537 ? 43.222 -7.975 -21.231 1.00 23.07 ? 565 ASP A CG 1 ATOM 4175 O OD1 . ASP A 1 537 ? 42.080 -8.324 -21.618 1.00 20.91 ? 565 ASP A OD1 1 ATOM 4176 O OD2 . ASP A 1 537 ? 43.816 -8.562 -20.298 1.00 22.22 ? 565 ASP A OD2 1 ATOM 4177 N N . LYS A 1 538 ? 45.561 -5.458 -24.236 1.00 23.56 ? 566 LYS A N 1 ATOM 4178 C CA . LYS A 1 538 ? 46.387 -4.360 -24.779 1.00 23.44 ? 566 LYS A CA 1 ATOM 4179 C C . LYS A 1 538 ? 45.722 -3.713 -26.012 1.00 23.52 ? 566 LYS A C 1 ATOM 4180 O O . LYS A 1 538 ? 45.547 -2.486 -26.062 1.00 23.85 ? 566 LYS A O 1 ATOM 4181 C CB . LYS A 1 538 ? 47.817 -4.844 -25.062 1.00 23.55 ? 566 LYS A CB 1 ATOM 4182 C CG . LYS A 1 538 ? 48.900 -3.766 -25.347 1.00 24.82 ? 566 LYS A CG 1 ATOM 4183 C CD . LYS A 1 538 ? 48.782 -3.196 -26.772 1.00 26.01 ? 566 LYS A CD 1 ATOM 4184 C CE . LYS A 1 538 ? 50.095 -2.594 -27.282 1.00 26.92 ? 566 LYS A CE 1 ATOM 4185 N NZ . LYS A 1 538 ? 49.903 -2.181 -28.711 1.00 27.19 ? 566 LYS A NZ 1 ATOM 4186 N N . ALA A 1 539 ? 45.308 -4.528 -26.981 1.00 23.31 ? 567 ALA A N 1 ATOM 4187 C CA . ALA A 1 539 ? 44.592 -4.010 -28.144 1.00 23.22 ? 567 ALA A CA 1 ATOM 4188 C C . ALA A 1 539 ? 43.269 -3.339 -27.727 1.00 24.15 ? 567 ALA A C 1 ATOM 4189 O O . ALA A 1 539 ? 42.872 -2.317 -28.310 1.00 25.06 ? 567 ALA A O 1 ATOM 4190 C CB . ALA A 1 539 ? 44.350 -5.083 -29.138 1.00 22.85 ? 567 ALA A CB 1 ATOM 4191 N N . SER A 1 540 ? 42.604 -3.881 -26.710 1.00 23.82 ? 568 SER A N 1 ATOM 4192 C CA . SER A 1 540 ? 41.402 -3.258 -26.201 1.00 24.42 ? 568 SER A CA 1 ATOM 4193 C C . SER A 1 540 ? 41.660 -1.801 -25.737 1.00 25.81 ? 568 SER A C 1 ATOM 4194 O O . SER A 1 540 ? 40.884 -0.907 -26.038 1.00 26.13 ? 568 SER A O 1 ATOM 4195 C CB . SER A 1 540 ? 40.794 -4.103 -25.077 1.00 24.18 ? 568 SER A CB 1 ATOM 4196 O OG . SER A 1 540 ? 40.194 -5.270 -25.584 1.00 21.30 ? 568 SER A OG 1 ATOM 4197 N N . LEU A 1 541 ? 42.748 -1.562 -25.016 1.00 27.04 ? 569 LEU A N 1 ATOM 4198 C CA . LEU A 1 541 ? 43.115 -0.212 -24.636 1.00 28.17 ? 569 LEU A CA 1 ATOM 4199 C C . LEU A 1 541 ? 43.433 0.659 -25.852 1.00 29.41 ? 569 LEU A C 1 ATOM 4200 O O . LEU A 1 541 ? 42.978 1.796 -25.911 1.00 29.92 ? 569 LEU A O 1 ATOM 4201 C CB . LEU A 1 541 ? 44.327 -0.232 -23.729 1.00 27.81 ? 569 LEU A CB 1 ATOM 4202 C CG . LEU A 1 541 ? 44.151 -0.643 -22.286 1.00 27.70 ? 569 LEU A CG 1 ATOM 4203 C CD1 . LEU A 1 541 ? 45.461 -0.302 -21.599 1.00 29.09 ? 569 LEU A CD1 1 ATOM 4204 C CD2 . LEU A 1 541 ? 42.981 0.066 -21.636 1.00 25.66 ? 569 LEU A CD2 1 ATOM 4205 N N . ASP A 1 542 ? 44.227 0.135 -26.796 1.00 30.32 ? 570 ASP A N 1 ATOM 4206 C CA . ASP A 1 542 ? 44.460 0.797 -28.083 1.00 30.87 ? 570 ASP A CA 1 ATOM 4207 C C . ASP A 1 542 ? 43.140 1.226 -28.725 1.00 31.56 ? 570 ASP A C 1 ATOM 4208 O O . ASP A 1 542 ? 43.056 2.320 -29.270 1.00 31.40 ? 570 ASP A O 1 ATOM 4209 C CB . ASP A 1 542 ? 45.191 -0.127 -29.060 1.00 30.85 ? 570 ASP A CB 1 ATOM 4210 C CG . ASP A 1 542 ? 46.662 -0.285 -28.751 1.00 30.56 ? 570 ASP A CG 1 ATOM 4211 O OD1 . ASP A 1 542 ? 47.177 0.364 -27.811 1.00 29.00 ? 570 ASP A OD1 1 ATOM 4212 O OD2 . ASP A 1 542 ? 47.305 -1.082 -29.472 1.00 30.24 ? 570 ASP A OD2 1 ATOM 4213 N N . MET A 1 543 ? 42.129 0.356 -28.674 1.00 32.38 ? 571 MET A N 1 ATOM 4214 C CA . MET A 1 543 ? 40.774 0.704 -29.124 1.00 33.70 ? 571 MET A CA 1 ATOM 4215 C C . MET A 1 543 ? 40.175 1.904 -28.379 1.00 34.47 ? 571 MET A C 1 ATOM 4216 O O . MET A 1 543 ? 39.633 2.800 -29.019 1.00 35.36 ? 571 MET A O 1 ATOM 4217 C CB . MET A 1 543 ? 39.817 -0.476 -28.980 1.00 33.60 ? 571 MET A CB 1 ATOM 4218 C CG . MET A 1 543 ? 39.654 -1.335 -30.197 1.00 34.62 ? 571 MET A CG 1 ATOM 4219 S SD . MET A 1 543 ? 38.473 -2.639 -29.806 1.00 37.36 ? 571 MET A SD 1 ATOM 4220 C CE . MET A 1 543 ? 36.917 -1.903 -30.236 1.00 37.32 ? 571 MET A CE 1 ATOM 4221 N N . ILE A 1 544 ? 40.247 1.900 -27.042 1.00 34.64 ? 572 ILE A N 1 ATOM 4222 C CA . ILE A 1 544 ? 39.735 2.993 -26.219 1.00 34.83 ? 572 ILE A CA 1 ATOM 4223 C C . ILE A 1 544 ? 40.461 4.279 -26.579 1.00 35.20 ? 572 ILE A C 1 ATOM 4224 O O . ILE A 1 544 ? 39.815 5.307 -26.819 1.00 35.64 ? 572 ILE A O 1 ATOM 4225 C CB . ILE A 1 544 ? 39.916 2.764 -24.663 1.00 35.09 ? 572 ILE A CB 1 ATOM 4226 C CG1 . ILE A 1 544 ? 39.308 1.438 -24.151 1.00 35.46 ? 572 ILE A CG1 1 ATOM 4227 C CG2 . ILE A 1 544 ? 39.405 3.964 -23.874 1.00 33.98 ? 572 ILE A CG2 1 ATOM 4228 C CD1 . ILE A 1 544 ? 37.960 1.031 -24.756 1.00 38.62 ? 572 ILE A CD1 1 ATOM 4229 N N . VAL A 1 545 ? 41.795 4.217 -26.597 1.00 35.15 ? 573 VAL A N 1 ATOM 4230 C CA . VAL A 1 545 ? 42.629 5.377 -26.898 1.00 35.47 ? 573 VAL A CA 1 ATOM 4231 C C . VAL A 1 545 ? 42.359 5.955 -28.300 1.00 36.02 ? 573 VAL A C 1 ATOM 4232 O O . VAL A 1 545 ? 42.260 7.165 -28.449 1.00 36.44 ? 573 VAL A O 1 ATOM 4233 C CB . VAL A 1 545 ? 44.139 5.088 -26.688 1.00 35.41 ? 573 VAL A CB 1 ATOM 4234 C CG1 . VAL A 1 545 ? 45.023 6.245 -27.233 1.00 35.10 ? 573 VAL A CG1 1 ATOM 4235 C CG2 . VAL A 1 545 ? 44.431 4.843 -25.204 1.00 35.92 ? 573 VAL A CG2 1 ATOM 4236 N N . ALA A 1 546 ? 42.218 5.097 -29.306 1.00 36.39 ? 574 ALA A N 1 ATOM 4237 C CA . ALA A 1 546 ? 42.000 5.553 -30.679 1.00 37.10 ? 574 ALA A CA 1 ATOM 4238 C C . ALA A 1 546 ? 40.602 6.134 -30.897 1.00 37.99 ? 574 ALA A C 1 ATOM 4239 O O . ALA A 1 546 ? 40.441 7.055 -31.692 1.00 38.32 ? 574 ALA A O 1 ATOM 4240 C CB . ALA A 1 546 ? 42.270 4.445 -31.675 1.00 36.75 ? 574 ALA A CB 1 ATOM 4241 N N . GLN A 1 547 ? 39.597 5.591 -30.214 1.00 38.80 ? 575 GLN A N 1 ATOM 4242 C CA . GLN A 1 547 ? 38.254 6.162 -30.226 1.00 39.89 ? 575 GLN A CA 1 ATOM 4243 C C . GLN A 1 547 ? 38.274 7.555 -29.591 1.00 40.50 ? 575 GLN A C 1 ATOM 4244 O O . GLN A 1 547 ? 37.651 8.488 -30.101 1.00 40.78 ? 575 GLN A O 1 ATOM 4245 C CB . GLN A 1 547 ? 37.289 5.249 -29.476 1.00 40.12 ? 575 GLN A CB 1 ATOM 4246 C CG . GLN A 1 547 ? 35.928 5.860 -29.157 1.00 42.65 ? 575 GLN A CG 1 ATOM 4247 C CD . GLN A 1 547 ? 34.951 4.834 -28.563 1.00 46.38 ? 575 GLN A CD 1 ATOM 4248 O OE1 . GLN A 1 547 ? 35.231 4.197 -27.532 1.00 47.40 ? 575 GLN A OE1 1 ATOM 4249 N NE2 . GLN A 1 547 ? 33.799 4.673 -29.211 1.00 46.21 ? 575 GLN A NE2 1 ATOM 4250 N N . LEU A 1 548 ? 38.998 7.686 -28.482 1.00 41.04 ? 576 LEU A N 1 ATOM 4251 C CA . LEU A 1 548 ? 39.186 8.975 -27.830 1.00 41.51 ? 576 LEU A CA 1 ATOM 4252 C C . LEU A 1 548 ? 39.873 9.970 -28.757 1.00 41.99 ? 576 LEU A C 1 ATOM 4253 O O . LEU A 1 548 ? 39.511 11.137 -28.767 1.00 42.18 ? 576 LEU A O 1 ATOM 4254 C CB . LEU A 1 548 ? 40.018 8.840 -26.544 1.00 41.45 ? 576 LEU A CB 1 ATOM 4255 C CG . LEU A 1 548 ? 39.442 8.288 -25.234 1.00 41.13 ? 576 LEU A CG 1 ATOM 4256 C CD1 . LEU A 1 548 ? 40.522 8.434 -24.155 1.00 39.40 ? 576 LEU A CD1 1 ATOM 4257 C CD2 . LEU A 1 548 ? 38.123 8.982 -24.820 1.00 40.29 ? 576 LEU A CD2 1 ATOM 4258 N N . ASN A 1 549 ? 40.866 9.505 -29.518 1.00 42.44 ? 577 ASN A N 1 ATOM 4259 C CA . ASN A 1 549 ? 41.651 10.357 -30.415 1.00 42.71 ? 577 ASN A CA 1 ATOM 4260 C C . ASN A 1 549 ? 40.982 10.532 -31.775 1.00 42.70 ? 577 ASN A C 1 ATOM 4261 O O . ASN A 1 549 ? 41.612 11.030 -32.702 1.00 42.39 ? 577 ASN A O 1 ATOM 4262 C CB . ASN A 1 549 ? 43.065 9.782 -30.614 1.00 43.01 ? 577 ASN A CB 1 ATOM 4263 C CG . ASN A 1 549 ? 44.022 10.100 -29.455 1.00 44.66 ? 577 ASN A CG 1 ATOM 4264 O OD1 . ASN A 1 549 ? 43.889 11.116 -28.777 1.00 48.02 ? 577 ASN A OD1 1 ATOM 4265 N ND2 . ASN A 1 549 ? 45.010 9.229 -29.246 1.00 45.89 ? 577 ASN A ND2 1 ATOM 4266 N N . GLU A 1 550 ? 39.709 10.121 -31.875 1.00 43.28 ? 578 GLU A N 1 ATOM 4267 C CA . GLU A 1 550 ? 38.924 10.052 -33.137 1.00 43.98 ? 578 GLU A CA 1 ATOM 4268 C C . GLU A 1 550 ? 39.723 9.479 -34.352 1.00 43.40 ? 578 GLU A C 1 ATOM 4269 O O . GLU A 1 550 ? 39.544 9.938 -35.476 1.00 44.13 ? 578 GLU A O 1 ATOM 4270 C CB . GLU A 1 550 ? 38.231 11.421 -33.458 1.00 44.99 ? 578 GLU A CB 1 ATOM 4271 C CG . GLU A 1 550 ? 36.820 11.736 -32.754 1.00 48.01 ? 578 GLU A CG 1 ATOM 4272 C CD . GLU A 1 550 ? 36.436 13.272 -32.709 1.00 52.21 ? 578 GLU A CD 1 ATOM 4273 O OE1 . GLU A 1 550 ? 37.254 14.105 -32.254 1.00 53.24 ? 578 GLU A OE1 1 ATOM 4274 O OE2 . GLU A 1 550 ? 35.304 13.655 -33.112 1.00 53.36 ? 578 GLU A OE2 1 ATOM 4275 N N . ASP A 1 551 ? 40.587 8.479 -34.113 1.00 42.59 ? 579 ASP A N 1 ATOM 4276 C CA . ASP A 1 551 ? 41.490 7.871 -35.129 1.00 41.26 ? 579 ASP A CA 1 ATOM 4277 C C . ASP A 1 551 ? 40.908 6.552 -35.664 1.00 40.79 ? 579 ASP A C 1 ATOM 4278 O O . ASP A 1 551 ? 40.966 5.526 -34.996 1.00 41.00 ? 579 ASP A O 1 ATOM 4279 C CB . ASP A 1 551 ? 42.885 7.643 -34.509 1.00 41.03 ? 579 ASP A CB 1 ATOM 4280 C CG . ASP A 1 551 ? 43.958 7.212 -35.530 1.00 40.42 ? 579 ASP A CG 1 ATOM 4281 O OD1 . ASP A 1 551 ? 43.630 6.861 -36.687 1.00 39.95 ? 579 ASP A OD1 1 ATOM 4282 O OD2 . ASP A 1 551 ? 45.153 7.214 -35.152 1.00 38.28 ? 579 ASP A OD2 1 ATOM 4283 N N . THR A 1 552 ? 40.336 6.582 -36.863 1.00 40.30 ? 580 THR A N 1 ATOM 4284 C CA . THR A 1 552 ? 39.628 5.413 -37.406 1.00 39.98 ? 580 THR A CA 1 ATOM 4285 C C . THR A 1 552 ? 40.570 4.266 -37.845 1.00 39.27 ? 580 THR A C 1 ATOM 4286 O O . THR A 1 552 ? 40.317 3.093 -37.551 1.00 39.03 ? 580 THR A O 1 ATOM 4287 C CB . THR A 1 552 ? 38.677 5.829 -38.552 1.00 40.21 ? 580 THR A CB 1 ATOM 4288 O OG1 . THR A 1 552 ? 37.781 6.823 -38.060 1.00 40.50 ? 580 THR A OG1 1 ATOM 4289 C CG2 . THR A 1 552 ? 37.839 4.625 -39.078 1.00 41.23 ? 580 THR A CG2 1 ATOM 4290 N N . GLU A 1 553 ? 41.642 4.627 -38.553 1.00 38.70 ? 581 GLU A N 1 ATOM 4291 C CA . GLU A 1 553 ? 42.716 3.703 -38.935 1.00 37.95 ? 581 GLU A CA 1 ATOM 4292 C C . GLU A 1 553 ? 43.178 2.853 -37.710 1.00 37.22 ? 581 GLU A C 1 ATOM 4293 O O . GLU A 1 553 ? 43.077 1.611 -37.741 1.00 36.70 ? 581 GLU A O 1 ATOM 4294 C CB . GLU A 1 553 ? 43.872 4.479 -39.632 1.00 38.28 ? 581 GLU A CB 1 ATOM 4295 C CG . GLU A 1 553 ? 45.102 3.644 -40.159 1.00 38.42 ? 581 GLU A CG 1 ATOM 4296 C CD . GLU A 1 553 ? 45.736 4.248 -41.397 0.010 38.16 ? 581 GLU A CD 1 ATOM 4297 O OE1 . GLU A 1 553 ? 45.921 5.484 -41.439 0.010 38.14 ? 581 GLU A OE1 1 ATOM 4298 O OE2 . GLU A 1 553 ? 46.060 3.485 -42.331 0.010 38.12 ? 581 GLU A OE2 1 ATOM 4299 N N . ALA A 1 554 ? 43.624 3.528 -36.639 1.00 36.07 ? 582 ALA A N 1 ATOM 4300 C CA . ALA A 1 554 ? 44.078 2.867 -35.398 1.00 35.04 ? 582 ALA A CA 1 ATOM 4301 C C . ALA A 1 554 ? 42.996 2.036 -34.693 1.00 34.34 ? 582 ALA A C 1 ATOM 4302 O O . ALA A 1 554 ? 43.281 0.961 -34.182 1.00 33.88 ? 582 ALA A O 1 ATOM 4303 C CB . ALA A 1 554 ? 44.686 3.870 -34.441 1.00 34.83 ? 582 ALA A CB 1 ATOM 4304 N N . TYR A 1 555 ? 41.767 2.539 -34.680 1.00 33.79 ? 583 TYR A N 1 ATOM 4305 C CA . TYR A 1 555 ? 40.645 1.840 -34.055 1.00 33.35 ? 583 TYR A CA 1 ATOM 4306 C C . TYR A 1 555 ? 40.306 0.525 -34.732 1.00 33.06 ? 583 TYR A C 1 ATOM 4307 O O . TYR A 1 555 ? 40.188 -0.484 -34.063 1.00 33.27 ? 583 TYR A O 1 ATOM 4308 C CB . TYR A 1 555 ? 39.405 2.737 -34.027 1.00 33.55 ? 583 TYR A CB 1 ATOM 4309 C CG . TYR A 1 555 ? 38.177 2.088 -33.428 1.00 33.29 ? 583 TYR A CG 1 ATOM 4310 C CD1 . TYR A 1 555 ? 38.022 2.001 -32.043 1.00 34.26 ? 583 TYR A CD1 1 ATOM 4311 C CD2 . TYR A 1 555 ? 37.160 1.573 -34.243 1.00 33.27 ? 583 TYR A CD2 1 ATOM 4312 C CE1 . TYR A 1 555 ? 36.895 1.413 -31.479 1.00 34.08 ? 583 TYR A CE1 1 ATOM 4313 C CE2 . TYR A 1 555 ? 36.040 0.963 -33.688 1.00 33.68 ? 583 TYR A CE2 1 ATOM 4314 C CZ . TYR A 1 555 ? 35.919 0.896 -32.303 1.00 34.39 ? 583 TYR A CZ 1 ATOM 4315 O OH . TYR A 1 555 ? 34.819 0.316 -31.725 1.00 37.51 ? 583 TYR A OH 1 ATOM 4316 N N . GLU A 1 556 ? 40.140 0.537 -36.053 1.00 32.86 ? 584 GLU A N 1 ATOM 4317 C CA . GLU A 1 556 ? 39.778 -0.675 -36.792 1.00 32.94 ? 584 GLU A CA 1 ATOM 4318 C C . GLU A 1 556 ? 40.893 -1.727 -36.779 1.00 32.28 ? 584 GLU A C 1 ATOM 4319 O O . GLU A 1 556 ? 40.627 -2.931 -36.790 1.00 32.62 ? 584 GLU A O 1 ATOM 4320 C CB . GLU A 1 556 ? 39.358 -0.356 -38.231 1.00 33.23 ? 584 GLU A CB 1 ATOM 4321 C CG . GLU A 1 556 ? 37.965 0.303 -38.381 1.00 36.66 ? 584 GLU A CG 1 ATOM 4322 C CD . GLU A 1 556 ? 36.772 -0.602 -37.977 1.00 41.61 ? 584 GLU A CD 1 ATOM 4323 O OE1 . GLU A 1 556 ? 36.653 -1.739 -38.520 1.00 43.01 ? 584 GLU A OE1 1 ATOM 4324 O OE2 . GLU A 1 556 ? 35.931 -0.162 -37.136 1.00 42.54 ? 584 GLU A OE2 1 ATOM 4325 N N . SER A 1 557 ? 42.135 -1.267 -36.745 1.00 31.46 ? 585 SER A N 1 ATOM 4326 C CA . SER A 1 557 ? 43.279 -2.150 -36.693 1.00 31.08 ? 585 SER A CA 1 ATOM 4327 C C . SER A 1 557 ? 43.358 -2.842 -35.314 1.00 30.74 ? 585 SER A C 1 ATOM 4328 O O . SER A 1 557 ? 43.414 -4.076 -35.237 1.00 30.84 ? 585 SER A O 1 ATOM 4329 C CB . SER A 1 557 ? 44.543 -1.365 -37.035 1.00 30.83 ? 585 SER A CB 1 ATOM 4330 O OG . SER A 1 557 ? 45.684 -1.886 -36.383 1.00 32.60 ? 585 SER A OG 1 ATOM 4331 N N . ALA A 1 558 ? 43.337 -2.043 -34.243 1.00 30.02 ? 586 ALA A N 1 ATOM 4332 C CA . ALA A 1 558 ? 43.251 -2.553 -32.875 1.00 29.22 ? 586 ALA A CA 1 ATOM 4333 C C . ALA A 1 558 ? 42.033 -3.467 -32.656 1.00 28.97 ? 586 ALA A C 1 ATOM 4334 O O . ALA A 1 558 ? 42.170 -4.521 -32.045 1.00 29.03 ? 586 ALA A O 1 ATOM 4335 C CB . ALA A 1 558 ? 43.261 -1.420 -31.875 1.00 28.78 ? 586 ALA A CB 1 ATOM 4336 N N . LYS A 1 559 ? 40.869 -3.101 -33.193 1.00 28.26 ? 587 LYS A N 1 ATOM 4337 C CA . LYS A 1 559 ? 39.667 -3.920 -33.041 1.00 27.53 ? 587 LYS A CA 1 ATOM 4338 C C . LYS A 1 559 ? 39.825 -5.317 -33.588 1.00 27.41 ? 587 LYS A C 1 ATOM 4339 O O . LYS A 1 559 ? 39.476 -6.272 -32.906 1.00 28.22 ? 587 LYS A O 1 ATOM 4340 C CB . LYS A 1 559 ? 38.458 -3.278 -33.703 1.00 27.74 ? 587 LYS A CB 1 ATOM 4341 C CG . LYS A 1 559 ? 37.158 -4.008 -33.423 1.00 27.80 ? 587 LYS A CG 1 ATOM 4342 C CD . LYS A 1 559 ? 36.014 -3.495 -34.287 1.00 31.63 ? 587 LYS A CD 1 ATOM 4343 C CE . LYS A 1 559 ? 34.669 -3.650 -33.564 1.00 34.98 ? 587 LYS A CE 1 ATOM 4344 N NZ . LYS A 1 559 ? 33.531 -3.141 -34.366 1.00 36.36 ? 587 LYS A NZ 1 ATOM 4345 N N . GLU A 1 560 ? 40.314 -5.445 -34.822 1.00 26.70 ? 588 GLU A N 1 ATOM 4346 C CA . GLU A 1 560 ? 40.534 -6.764 -35.428 1.00 25.72 ? 588 GLU A CA 1 ATOM 4347 C C . GLU A 1 560 ? 41.479 -7.634 -34.555 1.00 25.39 ? 588 GLU A C 1 ATOM 4348 O O . GLU A 1 560 ? 41.206 -8.823 -34.341 1.00 25.43 ? 588 GLU A O 1 ATOM 4349 C CB . GLU A 1 560 ? 41.064 -6.641 -36.879 1.00 25.35 ? 588 GLU A CB 1 ATOM 4350 C CG . GLU A 1 560 ? 41.667 -7.952 -37.441 1.00 24.94 ? 588 GLU A CG 1 ATOM 4351 C CD . GLU A 1 560 ? 42.065 -7.909 -38.908 1.00 25.55 ? 588 GLU A CD 1 ATOM 4352 O OE1 . GLU A 1 560 ? 41.698 -6.973 -39.644 1.00 26.54 ? 588 GLU A OE1 1 ATOM 4353 O OE2 . GLU A 1 560 ? 42.758 -8.840 -39.343 1.00 25.96 ? 588 GLU A OE2 1 ATOM 4354 N N . ILE A 1 561 ? 42.580 -7.034 -34.079 1.00 24.54 ? 589 ILE A N 1 ATOM 4355 C CA . ILE A 1 561 ? 43.568 -7.696 -33.217 1.00 23.38 ? 589 ILE A CA 1 ATOM 4356 C C . ILE A 1 561 ? 42.924 -8.139 -31.914 1.00 23.96 ? 589 ILE A C 1 ATOM 4357 O O . ILE A 1 561 ? 43.137 -9.272 -31.469 1.00 24.28 ? 589 ILE A O 1 ATOM 4358 C CB . ILE A 1 561 ? 44.792 -6.794 -32.908 1.00 23.07 ? 589 ILE A CB 1 ATOM 4359 C CG1 . ILE A 1 561 ? 45.588 -6.489 -34.189 1.00 20.37 ? 589 ILE A CG1 1 ATOM 4360 C CG2 . ILE A 1 561 ? 45.672 -7.437 -31.822 1.00 21.65 ? 589 ILE A CG2 1 ATOM 4361 C CD1 . ILE A 1 561 ? 46.587 -5.315 -34.055 1.00 16.19 ? 589 ILE A CD1 1 ATOM 4362 N N . ALA A 1 562 ? 42.122 -7.263 -31.313 1.00 23.99 ? 590 ALA A N 1 ATOM 4363 C CA . ALA A 1 562 ? 41.367 -7.652 -30.125 1.00 24.48 ? 590 ALA A CA 1 ATOM 4364 C C . ALA A 1 562 ? 40.434 -8.852 -30.394 1.00 25.05 ? 590 ALA A C 1 ATOM 4365 O O . ALA A 1 562 ? 40.381 -9.761 -29.574 1.00 26.16 ? 590 ALA A O 1 ATOM 4366 C CB . ALA A 1 562 ? 40.610 -6.481 -29.523 1.00 23.40 ? 590 ALA A CB 1 ATOM 4367 N N . GLN A 1 563 ? 39.730 -8.877 -31.526 1.00 25.22 ? 591 GLN A N 1 ATOM 4368 C CA . GLN A 1 563 ? 38.799 -9.967 -31.837 1.00 25.93 ? 591 GLN A CA 1 ATOM 4369 C C . GLN A 1 563 ? 39.552 -11.254 -32.113 1.00 25.35 ? 591 GLN A C 1 ATOM 4370 O O . GLN A 1 563 ? 39.088 -12.345 -31.749 1.00 25.05 ? 591 GLN A O 1 ATOM 4371 C CB . GLN A 1 563 ? 37.915 -9.642 -33.055 1.00 26.26 ? 591 GLN A CB 1 ATOM 4372 C CG . GLN A 1 563 ? 36.681 -8.790 -32.746 1.00 31.77 ? 591 GLN A CG 1 ATOM 4373 C CD . GLN A 1 563 ? 36.112 -8.020 -33.989 1.00 37.36 ? 591 GLN A CD 1 ATOM 4374 O OE1 . GLN A 1 563 ? 36.866 -7.519 -34.844 1.00 39.44 ? 591 GLN A OE1 1 ATOM 4375 N NE2 . GLN A 1 563 ? 34.784 -7.925 -34.068 1.00 36.03 ? 591 GLN A NE2 1 ATOM 4376 N N . ASN A 1 564 ? 40.702 -11.119 -32.770 1.00 24.84 ? 592 ASN A N 1 ATOM 4377 C CA . ASN A 1 564 ? 41.565 -12.255 -33.088 1.00 24.75 ? 592 ASN A CA 1 ATOM 4378 C C . ASN A 1 564 ? 42.005 -12.964 -31.798 1.00 24.21 ? 592 ASN A C 1 ATOM 4379 O O . ASN A 1 564 ? 41.913 -14.198 -31.695 1.00 23.93 ? 592 ASN A O 1 ATOM 4380 C CB . ASN A 1 564 ? 42.762 -11.760 -33.911 1.00 25.18 ? 592 ASN A CB 1 ATOM 4381 C CG . ASN A 1 564 ? 43.711 -12.870 -34.343 1.00 26.29 ? 592 ASN A CG 1 ATOM 4382 O OD1 . ASN A 1 564 ? 44.861 -12.901 -33.925 1.00 28.65 ? 592 ASN A OD1 1 ATOM 4383 N ND2 . ASN A 1 564 ? 43.249 -13.753 -35.206 1.00 27.69 ? 592 ASN A ND2 1 ATOM 4384 N N . LYS A 1 565 ? 42.424 -12.177 -30.804 1.00 23.67 ? 593 LYS A N 1 ATOM 4385 C CA . LYS A 1 565 ? 42.857 -12.723 -29.514 1.00 23.41 ? 593 LYS A CA 1 ATOM 4386 C C . LYS A 1 565 ? 41.701 -13.385 -28.785 1.00 24.11 ? 593 LYS A C 1 ATOM 4387 O O . LYS A 1 565 ? 41.842 -14.496 -28.265 1.00 24.66 ? 593 LYS A O 1 ATOM 4388 C CB . LYS A 1 565 ? 43.520 -11.664 -28.624 1.00 22.92 ? 593 LYS A CB 1 ATOM 4389 C CG . LYS A 1 565 ? 44.669 -10.905 -29.266 1.00 19.90 ? 593 LYS A CG 1 ATOM 4390 C CD . LYS A 1 565 ? 45.697 -11.843 -29.818 1.00 17.65 ? 593 LYS A CD 1 ATOM 4391 C CE . LYS A 1 565 ? 46.921 -11.085 -30.292 1.00 18.75 ? 593 LYS A CE 1 ATOM 4392 N NZ . LYS A 1 565 ? 47.871 -12.027 -30.941 1.00 19.81 ? 593 LYS A NZ 1 ATOM 4393 N N . LEU A 1 566 ? 40.546 -12.740 -28.772 1.00 24.46 ? 594 LEU A N 1 ATOM 4394 C CA . LEU A 1 566 ? 39.393 -13.344 -28.126 1.00 25.50 ? 594 LEU A CA 1 ATOM 4395 C C . LEU A 1 566 ? 38.944 -14.629 -28.816 1.00 26.13 ? 594 LEU A C 1 ATOM 4396 O O . LEU A 1 566 ? 38.612 -15.602 -28.149 1.00 26.75 ? 594 LEU A O 1 ATOM 4397 C CB . LEU A 1 566 ? 38.244 -12.344 -28.036 1.00 25.71 ? 594 LEU A CB 1 ATOM 4398 C CG . LEU A 1 566 ? 36.983 -12.771 -27.297 1.00 25.63 ? 594 LEU A CG 1 ATOM 4399 C CD1 . LEU A 1 566 ? 37.220 -12.854 -25.791 1.00 25.98 ? 594 LEU A CD1 1 ATOM 4400 C CD2 . LEU A 1 566 ? 35.894 -11.780 -27.620 1.00 26.35 ? 594 LEU A CD2 1 ATOM 4401 N N . ASN A 1 567 ? 38.925 -14.638 -30.146 1.00 26.92 ? 595 ASN A N 1 ATOM 4402 C CA . ASN A 1 567 ? 38.565 -15.839 -30.894 1.00 27.56 ? 595 ASN A CA 1 ATOM 4403 C C . ASN A 1 567 ? 39.474 -17.049 -30.571 1.00 28.20 ? 595 ASN A C 1 ATOM 4404 O O . ASN A 1 567 ? 39.006 -18.203 -30.463 1.00 27.97 ? 595 ASN A O 1 ATOM 4405 C CB . ASN A 1 567 ? 38.580 -15.551 -32.400 1.00 27.66 ? 595 ASN A CB 1 ATOM 4406 C CG . ASN A 1 567 ? 37.444 -14.624 -32.842 1.00 27.77 ? 595 ASN A CG 1 ATOM 4407 O OD1 . ASN A 1 567 ? 36.519 -14.347 -32.082 1.00 27.37 ? 595 ASN A OD1 1 ATOM 4408 N ND2 . ASN A 1 567 ? 37.517 -14.143 -34.081 1.00 25.98 ? 595 ASN A ND2 1 ATOM 4409 N N . THR A 1 568 ? 40.772 -16.774 -30.426 1.00 28.28 ? 596 THR A N 1 ATOM 4410 C CA . THR A 1 568 ? 41.720 -17.795 -30.025 1.00 28.65 ? 596 THR A CA 1 ATOM 4411 C C . THR A 1 568 ? 41.373 -18.332 -28.631 1.00 29.11 ? 596 THR A C 1 ATOM 4412 O O . THR A 1 568 ? 41.475 -19.527 -28.395 1.00 29.65 ? 596 THR A O 1 ATOM 4413 C CB . THR A 1 568 ? 43.165 -17.261 -30.021 1.00 28.55 ? 596 THR A CB 1 ATOM 4414 O OG1 . THR A 1 568 ? 43.526 -16.859 -31.337 1.00 28.43 ? 596 THR A OG1 1 ATOM 4415 C CG2 . THR A 1 568 ? 44.148 -18.320 -29.546 1.00 27.66 ? 596 THR A CG2 1 ATOM 4416 N N . ALA A 1 569 ? 40.962 -17.462 -27.717 1.00 29.14 ? 597 ALA A N 1 ATOM 4417 C CA . ALA A 1 569 ? 40.744 -17.886 -26.338 1.00 29.69 ? 597 ALA A CA 1 ATOM 4418 C C . ALA A 1 569 ? 39.430 -18.651 -26.193 1.00 29.97 ? 597 ALA A C 1 ATOM 4419 O O . ALA A 1 569 ? 39.355 -19.657 -25.472 1.00 30.64 ? 597 ALA A O 1 ATOM 4420 C CB . ALA A 1 569 ? 40.790 -16.698 -25.398 1.00 29.37 ? 597 ALA A CB 1 ATOM 4421 N N . LEU A 1 570 ? 38.413 -18.172 -26.899 1.00 29.94 ? 598 LEU A N 1 ATOM 4422 C CA . LEU A 1 570 ? 37.095 -18.783 -26.926 1.00 30.33 ? 598 LEU A CA 1 ATOM 4423 C C . LEU A 1 570 ? 37.101 -20.219 -27.460 1.00 30.44 ? 598 LEU A C 1 ATOM 4424 O O . LEU A 1 570 ? 36.290 -21.050 -27.040 1.00 30.75 ? 598 LEU A O 1 ATOM 4425 C CB . LEU A 1 570 ? 36.124 -17.932 -27.761 1.00 30.05 ? 598 LEU A CB 1 ATOM 4426 C CG . LEU A 1 570 ? 35.459 -16.694 -27.142 1.00 30.37 ? 598 LEU A CG 1 ATOM 4427 C CD1 . LEU A 1 570 ? 34.261 -16.237 -27.999 1.00 29.67 ? 598 LEU A CD1 1 ATOM 4428 C CD2 . LEU A 1 570 ? 35.028 -16.965 -25.699 1.00 30.35 ? 598 LEU A CD2 1 ATOM 4429 N N . SER A 1 571 ? 38.004 -20.517 -28.382 1.00 30.09 ? 599 SER A N 1 ATOM 4430 C CA . SER A 1 571 ? 38.002 -21.842 -28.987 1.00 30.37 ? 599 SER A CA 1 ATOM 4431 C C . SER A 1 571 ? 39.131 -22.770 -28.490 1.00 29.75 ? 599 SER A C 1 ATOM 4432 O O . SER A 1 571 ? 39.154 -23.929 -28.870 1.00 29.81 ? 599 SER A O 1 ATOM 4433 C CB . SER A 1 571 ? 38.058 -21.713 -30.504 1.00 30.78 ? 599 SER A CB 1 ATOM 4434 O OG . SER A 1 571 ? 39.224 -20.975 -30.854 1.00 32.72 ? 599 SER A OG 1 ATOM 4435 N N . SER A 1 572 ? 40.054 -22.248 -27.675 1.00 28.80 ? 600 SER A N 1 ATOM 4436 C CA . SER A 1 572 ? 41.107 -23.028 -27.014 1.00 27.92 ? 600 SER A CA 1 ATOM 4437 C C . SER A 1 572 ? 40.490 -23.808 -25.850 1.00 27.11 ? 600 SER A C 1 ATOM 4438 O O . SER A 1 572 ? 39.600 -23.298 -25.165 1.00 26.95 ? 600 SER A O 1 ATOM 4439 C CB . SER A 1 572 ? 42.143 -22.076 -26.407 1.00 27.87 ? 600 SER A CB 1 ATOM 4440 O OG . SER A 1 572 ? 41.520 -21.356 -25.340 1.00 29.45 ? 600 SER A OG 1 ATOM 4441 N N . PHE A 1 573 ? 40.996 -25.012 -25.607 1.00 25.67 ? 601 PHE A N 1 ATOM 4442 C CA . PHE A 1 573 ? 40.671 -25.794 -24.414 1.00 24.61 ? 601 PHE A CA 1 ATOM 4443 C C . PHE A 1 573 ? 41.007 -25.080 -23.074 1.00 23.65 ? 601 PHE A C 1 ATOM 4444 O O . PHE A 1 573 ? 40.187 -25.043 -22.149 1.00 23.17 ? 601 PHE A O 1 ATOM 4445 C CB . PHE A 1 573 ? 41.368 -27.163 -24.491 1.00 24.60 ? 601 PHE A CB 1 ATOM 4446 C CG . PHE A 1 573 ? 41.188 -28.002 -23.260 1.00 26.31 ? 601 PHE A CG 1 ATOM 4447 C CD1 . PHE A 1 573 ? 39.983 -28.697 -23.033 1.00 28.49 ? 601 PHE A CD1 1 ATOM 4448 C CD2 . PHE A 1 573 ? 42.204 -28.091 -22.307 1.00 27.03 ? 601 PHE A CD2 1 ATOM 4449 C CE1 . PHE A 1 573 ? 39.806 -29.480 -21.884 1.00 27.59 ? 601 PHE A CE1 1 ATOM 4450 C CE2 . PHE A 1 573 ? 42.034 -28.862 -21.144 1.00 27.55 ? 601 PHE A CE2 1 ATOM 4451 C CZ . PHE A 1 573 ? 40.830 -29.561 -20.936 1.00 27.95 ? 601 PHE A CZ 1 ATOM 4452 N N . ALA A 1 574 ? 42.213 -24.531 -22.970 1.00 22.63 ? 602 ALA A N 1 ATOM 4453 C CA . ALA A 1 574 ? 42.596 -23.724 -21.814 1.00 21.89 ? 602 ALA A CA 1 ATOM 4454 C C . ALA A 1 574 ? 41.570 -22.632 -21.515 1.00 21.61 ? 602 ALA A C 1 ATOM 4455 O O . ALA A 1 574 ? 41.041 -21.974 -22.420 1.00 21.52 ? 602 ALA A O 1 ATOM 4456 C CB . ALA A 1 574 ? 43.984 -23.113 -22.012 1.00 21.09 ? 602 ALA A CB 1 ATOM 4457 N N . VAL A 1 575 ? 41.283 -22.471 -20.231 1.00 21.42 ? 603 VAL A N 1 ATOM 4458 C CA . VAL A 1 575 ? 40.348 -21.463 -19.749 1.00 21.20 ? 603 VAL A CA 1 ATOM 4459 C C . VAL A 1 575 ? 41.031 -20.781 -18.586 1.00 21.22 ? 603 VAL A C 1 ATOM 4460 O O . VAL A 1 575 ? 41.625 -21.446 -17.741 1.00 21.42 ? 603 VAL A O 1 ATOM 4461 C CB . VAL A 1 575 ? 39.011 -22.110 -19.268 1.00 21.43 ? 603 VAL A CB 1 ATOM 4462 C CG1 . VAL A 1 575 ? 38.183 -21.102 -18.546 1.00 21.62 ? 603 VAL A CG1 1 ATOM 4463 C CG2 . VAL A 1 575 ? 38.211 -22.710 -20.449 1.00 19.51 ? 603 VAL A CG2 1 ATOM 4464 N N . ILE A 1 576 ? 40.976 -19.454 -18.561 1.00 21.38 ? 604 ILE A N 1 ATOM 4465 C CA . ILE A 1 576 ? 41.621 -18.644 -17.515 1.00 20.72 ? 604 ILE A CA 1 ATOM 4466 C C . ILE A 1 576 ? 41.050 -17.246 -17.556 1.00 21.17 ? 604 ILE A C 1 ATOM 4467 O O . ILE A 1 576 ? 40.570 -16.788 -18.612 1.00 21.02 ? 604 ILE A O 1 ATOM 4468 C CB . ILE A 1 576 ? 43.181 -18.594 -17.662 1.00 20.82 ? 604 ILE A CB 1 ATOM 4469 C CG1 . ILE A 1 576 ? 43.851 -18.191 -16.336 1.00 20.04 ? 604 ILE A CG1 1 ATOM 4470 C CG2 . ILE A 1 576 ? 43.613 -17.666 -18.790 1.00 19.45 ? 604 ILE A CG2 1 ATOM 4471 C CD1 . ILE A 1 576 ? 45.343 -18.389 -16.325 1.00 18.64 ? 604 ILE A CD1 1 ATOM 4472 N N . SER A 1 577 ? 41.094 -16.590 -16.398 1.00 21.91 ? 605 SER A N 1 ATOM 4473 C CA . SER A 1 577 ? 40.627 -15.213 -16.199 1.00 22.65 ? 605 SER A CA 1 ATOM 4474 C C . SER A 1 577 ? 39.320 -14.832 -16.916 1.00 22.88 ? 605 SER A C 1 ATOM 4475 O O . SER A 1 577 ? 39.188 -13.695 -17.366 1.00 22.72 ? 605 SER A O 1 ATOM 4476 C CB . SER A 1 577 ? 41.737 -14.255 -16.608 1.00 22.85 ? 605 SER A CB 1 ATOM 4477 O OG . SER A 1 577 ? 41.469 -12.948 -16.134 1.00 26.13 ? 605 SER A OG 1 ATOM 4478 N N . GLU A 1 578 ? 38.366 -15.771 -17.013 1.00 23.41 ? 606 GLU A N 1 ATOM 4479 C CA . GLU A 1 578 ? 37.084 -15.543 -17.704 1.00 24.55 ? 606 GLU A CA 1 ATOM 4480 C C . GLU A 1 578 ? 36.431 -14.159 -17.456 1.00 25.03 ? 606 GLU A C 1 ATOM 4481 O O . GLU A 1 578 ? 36.016 -13.464 -18.404 1.00 25.38 ? 606 GLU A O 1 ATOM 4482 C CB . GLU A 1 578 ? 36.060 -16.617 -17.339 1.00 24.46 ? 606 GLU A CB 1 ATOM 4483 C CG . GLU A 1 578 ? 36.482 -18.054 -17.594 1.00 26.30 ? 606 GLU A CG 1 ATOM 4484 C CD . GLU A 1 578 ? 36.900 -18.811 -16.317 1.00 25.51 ? 606 GLU A CD 1 ATOM 4485 O OE1 . GLU A 1 578 ? 37.955 -18.478 -15.726 1.00 21.99 ? 606 GLU A OE1 1 ATOM 4486 O OE2 . GLU A 1 578 ? 36.174 -19.760 -15.935 1.00 26.46 ? 606 GLU A OE2 1 ATOM 4487 N N . LYS A 1 579 ? 36.336 -13.775 -16.182 1.00 25.42 ? 607 LYS A N 1 ATOM 4488 C CA . LYS A 1 579 ? 35.580 -12.585 -15.781 1.00 25.31 ? 607 LYS A CA 1 ATOM 4489 C C . LYS A 1 579 ? 36.432 -11.326 -15.705 1.00 25.07 ? 607 LYS A C 1 ATOM 4490 O O . LYS A 1 579 ? 35.902 -10.259 -15.392 1.00 25.76 ? 607 LYS A O 1 ATOM 4491 C CB . LYS A 1 579 ? 34.806 -12.821 -14.458 1.00 25.32 ? 607 LYS A CB 1 ATOM 4492 C CG . LYS A 1 579 ? 33.600 -13.769 -14.614 1.00 25.73 ? 607 LYS A CG 1 ATOM 4493 C CD . LYS A 1 579 ? 32.555 -13.660 -13.488 1.00 27.75 ? 607 LYS A CD 1 ATOM 4494 C CE . LYS A 1 579 ? 31.336 -14.518 -13.776 0.010 27.21 ? 607 LYS A CE 1 ATOM 4495 N NZ . LYS A 1 579 ? 30.305 -14.388 -12.710 0.010 27.33 ? 607 LYS A NZ 1 ATOM 4496 N N . VAL A 1 580 ? 37.736 -11.448 -15.993 1.00 24.58 ? 608 VAL A N 1 ATOM 4497 C CA . VAL A 1 580 ? 38.681 -10.325 -15.892 1.00 23.50 ? 608 VAL A CA 1 ATOM 4498 C C . VAL A 1 580 ? 39.412 -10.103 -17.226 1.00 23.68 ? 608 VAL A C 1 ATOM 4499 O O . VAL A 1 580 ? 38.952 -9.306 -18.039 1.00 23.50 ? 608 VAL A O 1 ATOM 4500 C CB . VAL A 1 580 ? 39.673 -10.478 -14.701 1.00 23.65 ? 608 VAL A CB 1 ATOM 4501 C CG1 . VAL A 1 580 ? 40.546 -9.229 -14.546 1.00 22.62 ? 608 VAL A CG1 1 ATOM 4502 C CG2 . VAL A 1 580 ? 38.927 -10.742 -13.404 1.00 22.40 ? 608 VAL A CG2 1 ATOM 4503 N N . ALA A 1 581 ? 40.519 -10.806 -17.478 1.00 23.49 ? 609 ALA A N 1 ATOM 4504 C CA . ALA A 1 581 ? 41.277 -10.584 -18.716 1.00 23.54 ? 609 ALA A CA 1 ATOM 4505 C C . ALA A 1 581 ? 40.435 -10.857 -19.970 1.00 24.26 ? 609 ALA A C 1 ATOM 4506 O O . ALA A 1 581 ? 40.469 -10.090 -20.938 1.00 24.06 ? 609 ALA A O 1 ATOM 4507 C CB . ALA A 1 581 ? 42.530 -11.384 -18.727 1.00 23.05 ? 609 ALA A CB 1 ATOM 4508 N N . GLN A 1 582 ? 39.667 -11.943 -19.927 1.00 25.12 ? 610 GLN A N 1 ATOM 4509 C CA . GLN A 1 582 ? 38.785 -12.337 -21.023 1.00 26.20 ? 610 GLN A CA 1 ATOM 4510 C C . GLN A 1 582 ? 37.624 -11.339 -21.205 1.00 26.67 ? 610 GLN A C 1 ATOM 4511 O O . GLN A 1 582 ? 37.435 -10.778 -22.284 1.00 27.06 ? 610 GLN A O 1 ATOM 4512 C CB . GLN A 1 582 ? 38.270 -13.772 -20.810 1.00 25.73 ? 610 GLN A CB 1 ATOM 4513 C CG . GLN A 1 582 ? 37.234 -14.226 -21.838 1.00 27.22 ? 610 GLN A CG 1 ATOM 4514 C CD . GLN A 1 582 ? 37.202 -15.744 -22.059 1.00 28.95 ? 610 GLN A CD 1 ATOM 4515 O OE1 . GLN A 1 582 ? 36.147 -16.364 -21.957 1.00 29.97 ? 610 GLN A OE1 1 ATOM 4516 N NE2 . GLN A 1 582 ? 38.353 -16.336 -22.372 1.00 28.90 ? 610 GLN A NE2 1 ATOM 4517 N N . SER A 1 583 ? 36.876 -11.104 -20.135 1.00 27.22 ? 611 SER A N 1 ATOM 4518 C CA . SER A 1 583 ? 35.726 -10.221 -20.180 1.00 27.73 ? 611 SER A CA 1 ATOM 4519 C C . SER A 1 583 ? 36.068 -8.788 -20.624 1.00 27.81 ? 611 SER A C 1 ATOM 4520 O O . SER A 1 583 ? 35.277 -8.151 -21.321 1.00 28.42 ? 611 SER A O 1 ATOM 4521 C CB . SER A 1 583 ? 35.009 -10.216 -18.826 1.00 27.95 ? 611 SER A CB 1 ATOM 4522 O OG . SER A 1 583 ? 33.805 -9.470 -18.901 1.00 28.98 ? 611 SER A OG 1 ATOM 4523 N N . PHE A 1 584 ? 37.241 -8.288 -20.247 1.00 27.56 ? 612 PHE A N 1 ATOM 4524 C CA . PHE A 1 584 ? 37.653 -6.943 -20.635 1.00 27.46 ? 612 PHE A CA 1 ATOM 4525 C C . PHE A 1 584 ? 37.627 -6.764 -22.143 1.00 27.95 ? 612 PHE A C 1 ATOM 4526 O O . PHE A 1 584 ? 37.147 -5.743 -22.632 1.00 28.33 ? 612 PHE A O 1 ATOM 4527 C CB . PHE A 1 584 ? 39.042 -6.637 -20.117 1.00 27.38 ? 612 PHE A CB 1 ATOM 4528 C CG . PHE A 1 584 ? 39.457 -5.211 -20.296 1.00 27.55 ? 612 PHE A CG 1 ATOM 4529 C CD1 . PHE A 1 584 ? 38.714 -4.177 -19.740 1.00 28.46 ? 612 PHE A CD1 1 ATOM 4530 C CD2 . PHE A 1 584 ? 40.617 -4.893 -21.002 1.00 28.67 ? 612 PHE A CD2 1 ATOM 4531 C CE1 . PHE A 1 584 ? 39.117 -2.833 -19.893 1.00 27.97 ? 612 PHE A CE1 1 ATOM 4532 C CE2 . PHE A 1 584 ? 41.023 -3.556 -21.160 1.00 28.87 ? 612 PHE A CE2 1 ATOM 4533 C CZ . PHE A 1 584 ? 40.268 -2.527 -20.602 1.00 26.85 ? 612 PHE A CZ 1 ATOM 4534 N N . ILE A 1 585 ? 38.136 -7.753 -22.876 1.00 27.81 ? 613 ILE A N 1 ATOM 4535 C CA . ILE A 1 585 ? 38.090 -7.717 -24.330 1.00 27.42 ? 613 ILE A CA 1 ATOM 4536 C C . ILE A 1 585 ? 36.652 -7.753 -24.825 1.00 28.18 ? 613 ILE A C 1 ATOM 4537 O O . ILE A 1 585 ? 36.326 -7.022 -25.751 1.00 28.41 ? 613 ILE A O 1 ATOM 4538 C CB . ILE A 1 585 ? 38.869 -8.868 -25.002 1.00 27.13 ? 613 ILE A CB 1 ATOM 4539 C CG1 . ILE A 1 585 ? 40.258 -9.035 -24.394 1.00 25.60 ? 613 ILE A CG1 1 ATOM 4540 C CG2 . ILE A 1 585 ? 38.965 -8.619 -26.496 1.00 25.77 ? 613 ILE A CG2 1 ATOM 4541 C CD1 . ILE A 1 585 ? 40.936 -10.313 -24.810 1.00 24.93 ? 613 ILE A CD1 1 ATOM 4542 N N . GLN A 1 586 ? 35.805 -8.595 -24.226 1.00 28.77 ? 614 GLN A N 1 ATOM 4543 C CA . GLN A 1 586 ? 34.374 -8.657 -24.611 1.00 30.10 ? 614 GLN A CA 1 ATOM 4544 C C . GLN A 1 586 ? 33.651 -7.340 -24.369 1.00 30.55 ? 614 GLN A C 1 ATOM 4545 O O . GLN A 1 586 ? 32.806 -6.942 -25.159 1.00 30.75 ? 614 GLN A O 1 ATOM 4546 C CB . GLN A 1 586 ? 33.632 -9.793 -23.896 1.00 29.73 ? 614 GLN A CB 1 ATOM 4547 C CG . GLN A 1 586 ? 34.022 -11.161 -24.427 1.00 31.75 ? 614 GLN A CG 1 ATOM 4548 C CD . GLN A 1 586 ? 33.483 -12.330 -23.616 1.00 32.55 ? 614 GLN A CD 1 ATOM 4549 O OE1 . GLN A 1 586 ? 33.548 -12.352 -22.383 1.00 31.86 ? 614 GLN A OE1 1 ATOM 4550 N NE2 . GLN A 1 586 ? 32.970 -13.328 -24.322 1.00 33.95 ? 614 GLN A NE2 1 ATOM 4551 N N . GLU A 1 587 ? 34.017 -6.678 -23.276 1.00 31.63 ? 615 GLU A N 1 ATOM 4552 C CA . GLU A 1 587 ? 33.454 -5.402 -22.876 1.00 32.50 ? 615 GLU A CA 1 ATOM 4553 C C . GLU A 1 587 ? 33.806 -4.323 -23.869 1.00 32.94 ? 615 GLU A C 1 ATOM 4554 O O . GLU A 1 587 ? 32.949 -3.522 -24.230 1.00 33.45 ? 615 GLU A O 1 ATOM 4555 C CB . GLU A 1 587 ? 33.945 -5.009 -21.477 1.00 32.32 ? 615 GLU A CB 1 ATOM 4556 C CG . GLU A 1 587 ? 33.265 -5.793 -20.353 1.00 33.49 ? 615 GLU A CG 1 ATOM 4557 C CD . GLU A 1 587 ? 34.066 -5.845 -19.052 1.00 35.58 ? 615 GLU A CD 1 ATOM 4558 O OE1 . GLU A 1 587 ? 34.910 -4.961 -18.794 1.00 34.57 ? 615 GLU A OE1 1 ATOM 4559 O OE2 . GLU A 1 587 ? 33.840 -6.791 -18.266 1.00 38.82 ? 615 GLU A OE2 1 ATOM 4560 N N . ALA A 1 588 ? 35.057 -4.319 -24.319 1.00 33.71 ? 616 ALA A N 1 ATOM 4561 C CA . ALA A 1 588 ? 35.560 -3.300 -25.233 1.00 34.78 ? 616 ALA A CA 1 ATOM 4562 C C . ALA A 1 588 ? 34.965 -3.399 -26.642 1.00 35.91 ? 616 ALA A C 1 ATOM 4563 O O . ALA A 1 588 ? 35.031 -2.435 -27.395 1.00 36.25 ? 616 ALA A O 1 ATOM 4564 C CB . ALA A 1 588 ? 37.081 -3.320 -25.286 1.00 34.49 ? 616 ALA A CB 1 ATOM 4565 N N . LEU A 1 589 ? 34.376 -4.546 -26.981 1.00 37.09 ? 617 LEU A N 1 ATOM 4566 C CA . LEU A 1 589 ? 33.723 -4.761 -28.265 1.00 38.45 ? 617 LEU A CA 1 ATOM 4567 C C . LEU A 1 589 ? 32.185 -4.497 -28.197 1.00 40.27 ? 617 LEU A C 1 ATOM 4568 O O . LEU A 1 589 ? 31.376 -5.407 -28.401 1.00 39.94 ? 617 LEU A O 1 ATOM 4569 C CB . LEU A 1 589 ? 34.058 -6.176 -28.772 1.00 37.87 ? 617 LEU A CB 1 ATOM 4570 C CG . LEU A 1 589 ? 35.540 -6.551 -28.998 1.00 37.30 ? 617 LEU A CG 1 ATOM 4571 C CD1 . LEU A 1 589 ? 35.757 -8.046 -29.096 1.00 35.19 ? 617 LEU A CD1 1 ATOM 4572 C CD2 . LEU A 1 589 ? 36.148 -5.886 -30.227 1.00 36.61 ? 617 LEU A CD2 1 ATOM 4573 N N . SER A 1 590 ? 31.800 -3.236 -27.917 1.00 42.81 ? 618 SER A N 1 ATOM 4574 C CA . SER A 1 590 ? 30.371 -2.814 -27.696 1.00 44.49 ? 618 SER A CA 1 ATOM 4575 C C . SER A 1 590 ? 30.108 -1.270 -27.900 1.00 45.50 ? 618 SER A C 1 ATOM 4576 O O . SER A 1 590 ? 28.967 -0.791 -28.168 1.00 45.62 ? 618 SER A O 1 ATOM 4577 C CB . SER A 1 590 ? 29.874 -3.281 -26.296 1.00 45.07 ? 618 SER A CB 1 ATOM 4578 O OG . SER A 1 590 ? 30.362 -4.585 -25.948 1.00 44.10 ? 618 SER A OG 1 ATOM 4579 N N . VAL B 2 1 ? 29.988 -39.958 -14.193 1.00 46.17 ? 402 VAL T N 1 ATOM 4580 C CA . VAL B 2 1 ? 31.039 -40.554 -15.092 1.00 46.23 ? 402 VAL T CA 1 ATOM 4581 C C . VAL B 2 1 ? 32.304 -39.668 -15.223 1.00 46.05 ? 402 VAL T C 1 ATOM 4582 O O . VAL B 2 1 ? 33.433 -40.180 -15.039 1.00 46.45 ? 402 VAL T O 1 ATOM 4583 C CB . VAL B 2 1 ? 30.435 -41.043 -16.467 1.00 46.19 ? 402 VAL T CB 1 ATOM 4584 C CG1 . VAL B 2 1 ? 31.418 -40.915 -17.659 1.00 45.98 ? 402 VAL T CG1 1 ATOM 4585 C CG2 . VAL B 2 1 ? 29.942 -42.485 -16.322 1.00 46.86 ? 402 VAL T CG2 1 ATOM 4586 N N . ALA B 2 2 ? 32.121 -38.367 -15.500 1.00 45.11 ? 403 ALA T N 1 ATOM 4587 C CA . ALA B 2 2 ? 33.253 -37.441 -15.701 1.00 44.66 ? 403 ALA T CA 1 ATOM 4588 C C . ALA B 2 2 ? 33.442 -36.451 -14.550 1.00 44.33 ? 403 ALA T C 1 ATOM 4589 O O . ALA B 2 2 ? 34.528 -35.872 -14.410 1.00 44.45 ? 403 ALA T O 1 ATOM 4590 C CB . ALA B 2 2 ? 33.148 -36.695 -17.059 1.00 44.12 ? 403 ALA T CB 1 ATOM 4591 N N . HIS B 2 3 ? 32.385 -36.286 -13.741 1.00 43.84 ? 404 HIS T N 1 ATOM 4592 C CA . HIS B 2 3 ? 32.308 -35.346 -12.606 1.00 43.50 ? 404 HIS T CA 1 ATOM 4593 C C . HIS B 2 3 ? 31.002 -35.570 -11.815 1.00 43.49 ? 404 HIS T C 1 ATOM 4594 O O . HIS B 2 3 ? 30.123 -36.296 -12.281 1.00 43.75 ? 404 HIS T O 1 ATOM 4595 C CB . HIS B 2 3 ? 32.399 -33.895 -13.083 1.00 43.15 ? 404 HIS T CB 1 ATOM 4596 C CG . HIS B 2 3 ? 31.357 -33.516 -14.095 1.00 43.32 ? 404 HIS T CG 1 ATOM 4597 N ND1 . HIS B 2 3 ? 30.068 -33.169 -13.746 1.00 42.48 ? 404 HIS T ND1 1 ATOM 4598 C CD2 . HIS B 2 3 ? 31.419 -33.421 -15.445 1.00 42.32 ? 404 HIS T CD2 1 ATOM 4599 C CE1 . HIS B 2 3 ? 29.381 -32.882 -14.836 1.00 42.91 ? 404 HIS T CE1 1 ATOM 4600 N NE2 . HIS B 2 3 ? 30.178 -33.025 -15.881 1.00 43.17 ? 404 HIS T NE2 1 ATOM 4601 N N . SER B 2 4 ? 30.881 -34.969 -10.627 1.00 43.22 ? 405 SER T N 1 ATOM 4602 C CA . SER B 2 4 ? 29.647 -35.053 -9.828 1.00 43.08 ? 405 SER T CA 1 ATOM 4603 C C . SER B 2 4 ? 28.573 -34.089 -10.325 1.00 44.52 ? 405 SER T C 1 ATOM 4604 O O . SER B 2 4 ? 28.765 -33.356 -11.295 1.00 44.33 ? 405 SER T O 1 ATOM 4605 C CB . SER B 2 4 ? 29.915 -34.704 -8.362 1.00 41.88 ? 405 SER T CB 1 ATOM 4606 O OG . SER B 2 4 ? 30.739 -35.655 -7.746 1.00 38.40 ? 405 SER T OG 1 ATOM 4607 N N . GLY B 2 5 ? 27.445 -34.082 -9.619 1.00 46.13 ? 406 GLY T N 1 ATOM 4608 C CA . GLY B 2 5 ? 26.385 -33.102 -9.825 1.00 47.80 ? 406 GLY T CA 1 ATOM 4609 C C . GLY B 2 5 ? 25.734 -33.238 -11.187 1.00 49.12 ? 406 GLY T C 1 ATOM 4610 O O . GLY B 2 5 ? 25.843 -34.292 -11.840 1.00 49.05 ? 406 GLY T O 1 ATOM 4611 N N . ALA B 2 6 ? 25.080 -32.156 -11.624 1.00 50.02 ? 407 ALA T N 1 ATOM 4612 C CA . ALA B 2 6 ? 24.295 -32.161 -12.869 1.00 50.81 ? 407 ALA T CA 1 ATOM 4613 C C . ALA B 2 6 ? 25.040 -31.732 -14.169 1.00 51.23 ? 407 ALA T C 1 ATOM 4614 O O . ALA B 2 6 ? 26.226 -32.044 -14.393 1.00 51.54 ? 407 ALA T O 1 ATOM 4615 C CB . ALA B 2 6 ? 22.980 -31.344 -12.671 1.00 51.04 ? 407 ALA T CB 1 ATOM 4616 N N . LYS B 2 7 ? 24.318 -31.028 -15.037 1.00 51.57 ? 408 LYS T N 1 HETATM 4617 CD CD . CD C 3 . ? 59.170 -32.503 29.682 1.00 33.63 ? 1620 CD A CD 1 HETATM 4618 CD CD . CD D 3 . ? 71.289 -16.473 27.083 1.00 39.66 ? 1621 CD A CD 1 HETATM 4619 CD CD . CD E 3 . ? 45.178 -60.924 7.972 1.00 26.38 ? 1622 CD A CD 1 HETATM 4620 CD CD . CD F 3 . ? 71.799 -8.041 19.571 1.00 41.74 ? 1623 CD A CD 1 HETATM 4621 CD CD . CD G 3 . ? 15.093 -56.030 2.238 1.00 95.90 ? 1624 CD A CD 1 HETATM 4622 CD CD . CD H 3 . ? 62.531 -40.605 36.247 1.00 26.43 ? 1625 CD A CD 1 HETATM 4623 CD CD . CD I 3 . ? 48.354 5.753 -41.191 1.00 69.94 ? 1626 CD A CD 1 HETATM 4624 CD CD . CD J 3 . ? 73.144 -39.044 20.960 1.00 43.47 ? 1627 CD A CD 1 HETATM 4625 CD CD . CD K 3 . ? 59.914 -42.031 22.505 1.00 33.98 ? 1628 CD A CD 1 HETATM 4626 CD CD . CD L 3 . ? 48.589 -41.039 12.917 1.00 53.79 ? 1629 CD A CD 1 HETATM 4627 CD CD . CD M 3 . ? 71.457 -15.363 21.564 1.00 30.08 ? 1630 CD A CD 1 HETATM 4628 CD CD . CD N 3 . ? 35.670 -37.003 14.340 1.00 37.74 ? 1631 CD A CD 1 HETATM 4629 CD CD . CD O 3 . ? 45.196 -20.189 16.506 1.00 38.87 ? 1632 CD A CD 1 HETATM 4630 CD CD . CD P 3 . ? 59.432 -11.437 -14.289 1.00 55.92 ? 1633 CD A CD 1 HETATM 4631 CD CD . CD Q 3 . ? 31.504 -62.943 -5.261 1.00 40.32 ? 1634 CD A CD 1 HETATM 4632 CD CD . CD R 3 . ? 35.188 -14.277 -2.418 1.00 48.94 ? 1635 CD A CD 1 HETATM 4633 CD CD . CD S 3 . ? 42.863 -29.914 -16.387 1.00 64.71 ? 1636 CD A CD 1 HETATM 4634 CD CD . CD T 3 . ? 61.301 -35.431 33.024 1.00 75.85 ? 1637 CD A CD 1 HETATM 4635 C C1 . NAG U 4 . ? 31.327 -35.081 -6.566 1.00 29.94 ? 500 NAG T C1 1 HETATM 4636 C C2 . NAG U 4 . ? 32.150 -36.291 -6.106 1.00 25.31 ? 500 NAG T C2 1 HETATM 4637 C C3 . NAG U 4 . ? 33.650 -36.171 -6.373 1.00 23.57 ? 500 NAG T C3 1 HETATM 4638 C C4 . NAG U 4 . ? 33.918 -35.198 -7.506 1.00 22.13 ? 500 NAG T C4 1 HETATM 4639 C C5 . NAG U 4 . ? 33.400 -33.824 -7.095 1.00 23.01 ? 500 NAG T C5 1 HETATM 4640 C C6 . NAG U 4 . ? 33.541 -32.799 -8.203 1.00 22.81 ? 500 NAG T C6 1 HETATM 4641 C C7 . NAG U 4 . ? 31.847 -35.846 -3.660 1.00 24.64 ? 500 NAG T C7 1 HETATM 4642 C C8 . NAG U 4 . ? 31.612 -36.510 -2.327 1.00 23.09 ? 500 NAG T C8 1 HETATM 4643 N N2 . NAG U 4 . ? 31.912 -36.655 -4.714 1.00 23.66 ? 500 NAG T N2 1 HETATM 4644 O O3 . NAG U 4 . ? 34.217 -37.440 -6.646 1.00 20.88 ? 500 NAG T O3 1 HETATM 4645 O O4 . NAG U 4 . ? 35.299 -35.148 -7.777 1.00 19.00 ? 500 NAG T O4 1 HETATM 4646 O O5 . NAG U 4 . ? 32.036 -33.852 -6.733 1.00 27.09 ? 500 NAG T O5 1 HETATM 4647 O O6 . NAG U 4 . ? 33.050 -33.316 -9.428 1.00 21.63 ? 500 NAG T O6 1 HETATM 4648 O O7 . NAG U 4 . ? 31.967 -34.621 -3.719 1.00 25.77 ? 500 NAG T O7 1 HETATM 4649 CD CD . CD V 3 . ? 29.927 -32.535 -18.095 1.00 47.14 ? 1409 CD T CD 1 HETATM 4650 O O . HOH W 5 . ? 61.468 -12.048 12.636 1.00 31.14 ? 2001 HOH A O 1 HETATM 4651 O O . HOH W 5 . ? 60.998 -21.574 5.473 1.00 24.83 ? 2002 HOH A O 1 HETATM 4652 O O . HOH W 5 . ? 53.134 -18.783 8.973 1.00 22.07 ? 2003 HOH A O 1 HETATM 4653 O O . HOH W 5 . ? 55.710 -24.547 10.387 1.00 29.28 ? 2004 HOH A O 1 HETATM 4654 O O . HOH W 5 . ? 49.081 -17.599 16.025 1.00 31.31 ? 2005 HOH A O 1 HETATM 4655 O O . HOH W 5 . ? 59.022 -11.915 19.787 1.00 30.51 ? 2006 HOH A O 1 HETATM 4656 O O . HOH W 5 . ? 73.619 -8.480 20.326 1.00 19.02 ? 2007 HOH A O 1 HETATM 4657 O O . HOH W 5 . ? 71.379 -7.264 17.732 1.00 29.98 ? 2008 HOH A O 1 HETATM 4658 O O . HOH W 5 . ? 67.739 -9.606 20.051 1.00 44.73 ? 2009 HOH A O 1 HETATM 4659 O O . HOH W 5 . ? 71.266 -12.876 21.823 1.00 27.91 ? 2010 HOH A O 1 HETATM 4660 O O . HOH W 5 . ? 72.552 -15.421 19.732 1.00 27.98 ? 2011 HOH A O 1 HETATM 4661 O O . HOH W 5 . ? 74.905 -38.584 19.796 1.00 29.09 ? 2012 HOH A O 1 HETATM 4662 O O . HOH W 5 . ? 73.327 -41.581 16.402 1.00 30.18 ? 2013 HOH A O 1 HETATM 4663 O O . HOH W 5 . ? 71.635 -39.562 22.754 1.00 20.93 ? 2014 HOH A O 1 HETATM 4664 O O . HOH W 5 . ? 59.390 -43.686 20.849 1.00 19.83 ? 2015 HOH A O 1 HETATM 4665 O O . HOH W 5 . ? 59.436 -44.352 16.922 1.00 15.71 ? 2016 HOH A O 1 HETATM 4666 O O . HOH W 5 . ? 72.800 -39.566 10.431 1.00 24.89 ? 2017 HOH A O 1 HETATM 4667 O O . HOH W 5 . ? 76.372 -36.410 19.159 1.00 23.99 ? 2018 HOH A O 1 HETATM 4668 O O . HOH W 5 . ? 57.712 -41.890 23.072 1.00 30.28 ? 2019 HOH A O 1 HETATM 4669 O O . HOH W 5 . ? 63.972 -38.926 35.748 1.00 19.13 ? 2020 HOH A O 1 HETATM 4670 O O . HOH W 5 . ? 61.845 -26.867 31.077 1.00 27.03 ? 2021 HOH A O 1 HETATM 4671 O O . HOH W 5 . ? 58.709 -31.481 31.962 1.00 32.66 ? 2022 HOH A O 1 HETATM 4672 O O . HOH W 5 . ? 60.009 -28.713 29.736 1.00 36.96 ? 2023 HOH A O 1 HETATM 4673 O O . HOH W 5 . ? 54.665 -24.129 27.756 1.00 25.58 ? 2024 HOH A O 1 HETATM 4674 O O . HOH W 5 . ? 57.991 -30.586 29.375 1.00 34.30 ? 2025 HOH A O 1 HETATM 4675 O O . HOH W 5 . ? 46.984 -27.461 23.144 1.00 30.42 ? 2026 HOH A O 1 HETATM 4676 O O . HOH W 5 . ? 43.755 -39.364 18.956 1.00 32.41 ? 2027 HOH A O 1 HETATM 4677 O O . HOH W 5 . ? 45.467 -33.822 16.954 1.00 23.53 ? 2028 HOH A O 1 HETATM 4678 O O . HOH W 5 . ? 66.997 -15.936 25.669 1.00 24.58 ? 2029 HOH A O 1 HETATM 4679 O O . HOH W 5 . ? 69.819 -15.669 23.077 1.00 16.95 ? 2030 HOH A O 1 HETATM 4680 O O . HOH W 5 . ? 73.222 -15.613 26.675 1.00 10.18 ? 2031 HOH A O 1 HETATM 4681 O O . HOH W 5 . ? 51.245 -41.586 14.358 1.00 6.19 ? 2032 HOH A O 1 HETATM 4682 O O . HOH W 5 . ? 48.298 -38.357 13.690 1.00 8.25 ? 2033 HOH A O 1 HETATM 4683 O O . HOH W 5 . ? 51.887 -35.676 8.684 1.00 13.15 ? 2034 HOH A O 1 HETATM 4684 O O . HOH W 5 . ? 60.348 -35.107 6.421 1.00 32.86 ? 2035 HOH A O 1 HETATM 4685 O O . HOH W 5 . ? 59.274 -28.891 6.657 1.00 24.67 ? 2036 HOH A O 1 HETATM 4686 O O . HOH W 5 . ? 67.009 -19.051 9.203 1.00 24.02 ? 2037 HOH A O 1 HETATM 4687 O O . HOH W 5 . ? 53.122 -25.280 12.287 1.00 17.21 ? 2038 HOH A O 1 HETATM 4688 O O . HOH W 5 . ? 40.122 -34.636 -13.268 1.00 19.94 ? 2039 HOH A O 1 HETATM 4689 O O . HOH W 5 . ? 39.960 -41.409 -10.758 1.00 19.00 ? 2040 HOH A O 1 HETATM 4690 O O . HOH W 5 . ? 54.738 -43.782 -11.126 1.00 15.72 ? 2041 HOH A O 1 HETATM 4691 O O . HOH W 5 . ? 45.455 -45.689 -9.392 1.00 28.26 ? 2042 HOH A O 1 HETATM 4692 O O . HOH W 5 . ? 53.051 -34.504 -6.633 1.00 34.65 ? 2043 HOH A O 1 HETATM 4693 O O . HOH W 5 . ? 62.807 -30.686 2.563 1.00 30.81 ? 2044 HOH A O 1 HETATM 4694 O O . HOH W 5 . ? 48.221 -29.085 8.558 1.00 15.32 ? 2045 HOH A O 1 HETATM 4695 O O . HOH W 5 . ? 55.465 -27.551 8.880 1.00 29.60 ? 2046 HOH A O 1 HETATM 4696 O O . HOH W 5 . ? 35.801 -42.232 -4.628 1.00 22.22 ? 2047 HOH A O 1 HETATM 4697 O O . HOH W 5 . ? 36.219 -47.228 -10.806 1.00 37.96 ? 2048 HOH A O 1 HETATM 4698 O O . HOH W 5 . ? 33.103 -44.812 -10.758 1.00 12.63 ? 2049 HOH A O 1 HETATM 4699 O O . HOH W 5 . ? 30.681 -44.288 -5.289 1.00 19.61 ? 2050 HOH A O 1 HETATM 4700 O O . HOH W 5 . ? 33.052 -56.135 -8.146 1.00 14.02 ? 2051 HOH A O 1 HETATM 4701 O O . HOH W 5 . ? 53.402 -55.427 5.243 1.00 29.30 ? 2052 HOH A O 1 HETATM 4702 O O . HOH W 5 . ? 49.635 -44.855 7.660 1.00 16.98 ? 2053 HOH A O 1 HETATM 4703 O O . HOH W 5 . ? 46.802 -46.135 7.795 1.00 10.13 ? 2054 HOH A O 1 HETATM 4704 O O . HOH W 5 . ? 20.128 -68.517 3.056 1.00 7.94 ? 2055 HOH A O 1 HETATM 4705 O O . HOH W 5 . ? 32.717 -62.975 -0.331 1.00 32.54 ? 2056 HOH A O 1 HETATM 4706 O O . HOH W 5 . ? 42.273 -60.340 2.216 1.00 24.63 ? 2057 HOH A O 1 HETATM 4707 O O . HOH W 5 . ? 48.264 -58.202 9.558 1.00 30.73 ? 2058 HOH A O 1 HETATM 4708 O O . HOH W 5 . ? 44.185 -62.358 6.498 1.00 24.89 ? 2059 HOH A O 1 HETATM 4709 O O . HOH W 5 . ? 32.691 -42.841 -4.344 1.00 26.68 ? 2060 HOH A O 1 HETATM 4710 O O . HOH W 5 . ? 24.774 -39.270 -4.893 1.00 29.53 ? 2061 HOH A O 1 HETATM 4711 O O . HOH W 5 . ? 24.321 -46.522 -9.233 1.00 27.13 ? 2062 HOH A O 1 HETATM 4712 O O . HOH W 5 . ? 34.553 -46.008 13.865 1.00 22.30 ? 2063 HOH A O 1 HETATM 4713 O O . HOH W 5 . ? 40.291 -50.107 16.354 1.00 11.87 ? 2064 HOH A O 1 HETATM 4714 O O . HOH W 5 . ? 39.142 -45.959 9.850 1.00 20.38 ? 2065 HOH A O 1 HETATM 4715 O O . HOH W 5 . ? 22.724 -28.952 -3.961 1.00 28.91 ? 2066 HOH A O 1 HETATM 4716 O O . HOH W 5 . ? 29.684 -46.592 18.904 1.00 27.07 ? 2067 HOH A O 1 HETATM 4717 O O . HOH W 5 . ? 34.825 -40.744 15.722 1.00 31.81 ? 2068 HOH A O 1 HETATM 4718 O O . HOH W 5 . ? 32.483 -37.175 11.320 1.00 25.10 ? 2069 HOH A O 1 HETATM 4719 O O . HOH W 5 . ? 32.709 -28.607 -1.482 1.00 20.60 ? 2070 HOH A O 1 HETATM 4720 O O . HOH W 5 . ? 33.232 -26.156 -2.831 1.00 28.62 ? 2071 HOH A O 1 HETATM 4721 O O . HOH W 5 . ? 27.121 -18.537 9.904 1.00 32.97 ? 2072 HOH A O 1 HETATM 4722 O O . HOH W 5 . ? 33.137 -37.391 14.642 1.00 15.93 ? 2073 HOH A O 1 HETATM 4723 O O . HOH W 5 . ? 38.779 -23.019 -1.229 1.00 29.81 ? 2074 HOH A O 1 HETATM 4724 O O . HOH W 5 . ? 42.137 -28.513 -14.151 1.00 23.03 ? 2075 HOH A O 1 HETATM 4725 O O . HOH W 5 . ? 34.767 -32.246 -17.234 1.00 28.56 ? 2076 HOH A O 1 HETATM 4726 O O . HOH W 5 . ? 36.732 -26.649 -7.581 1.00 22.44 ? 2077 HOH A O 1 HETATM 4727 O O . HOH W 5 . ? 37.679 -16.814 3.135 1.00 30.39 ? 2078 HOH A O 1 HETATM 4728 O O . HOH W 5 . ? 38.591 -19.998 4.294 1.00 21.20 ? 2079 HOH A O 1 HETATM 4729 O O . HOH W 5 . ? 38.810 -21.324 15.055 1.00 15.64 ? 2080 HOH A O 1 HETATM 4730 O O . HOH W 5 . ? 37.979 -36.903 14.212 1.00 28.84 ? 2081 HOH A O 1 HETATM 4731 O O . HOH W 5 . ? 46.472 -25.388 -6.233 1.00 16.02 ? 2082 HOH A O 1 HETATM 4732 O O . HOH W 5 . ? 49.984 -21.165 2.977 1.00 34.87 ? 2083 HOH A O 1 HETATM 4733 O O . HOH W 5 . ? 47.829 -17.359 7.272 1.00 26.92 ? 2084 HOH A O 1 HETATM 4734 O O . HOH W 5 . ? 46.969 -19.606 10.161 1.00 27.60 ? 2085 HOH A O 1 HETATM 4735 O O . HOH W 5 . ? 44.225 -19.765 18.681 1.00 28.35 ? 2086 HOH A O 1 HETATM 4736 O O . HOH W 5 . ? 41.089 -15.441 5.671 1.00 17.44 ? 2087 HOH A O 1 HETATM 4737 O O . HOH W 5 . ? 45.875 -9.531 4.858 1.00 22.87 ? 2088 HOH A O 1 HETATM 4738 O O . HOH W 5 . ? 55.252 -14.904 1.902 1.00 21.05 ? 2089 HOH A O 1 HETATM 4739 O O . HOH W 5 . ? 52.776 -26.070 -7.324 1.00 21.54 ? 2090 HOH A O 1 HETATM 4740 O O . HOH W 5 . ? 54.584 -9.677 -4.624 1.00 32.01 ? 2091 HOH A O 1 HETATM 4741 O O . HOH W 5 . ? 59.266 -14.111 -10.382 1.00 20.13 ? 2092 HOH A O 1 HETATM 4742 O O . HOH W 5 . ? 48.182 -10.809 -11.522 1.00 18.16 ? 2093 HOH A O 1 HETATM 4743 O O . HOH W 5 . ? 36.740 -21.639 -2.285 1.00 23.79 ? 2094 HOH A O 1 HETATM 4744 O O . HOH W 5 . ? 43.140 8.074 -14.615 1.00 26.42 ? 2095 HOH A O 1 HETATM 4745 O O . HOH W 5 . ? 62.764 -22.643 -22.397 1.00 29.86 ? 2096 HOH A O 1 HETATM 4746 O O . HOH W 5 . ? 53.705 -32.861 -13.484 1.00 14.99 ? 2097 HOH A O 1 HETATM 4747 O O . HOH W 5 . ? 49.733 -34.628 -12.952 1.00 17.76 ? 2098 HOH A O 1 HETATM 4748 O O . HOH W 5 . ? 45.724 -28.544 -17.929 1.00 26.86 ? 2099 HOH A O 1 HETATM 4749 O O . HOH W 5 . ? 48.270 -27.203 -19.727 1.00 22.09 ? 2100 HOH A O 1 HETATM 4750 O O . HOH W 5 . ? 40.956 -9.859 -41.473 1.00 29.32 ? 2101 HOH A O 1 HETATM 4751 O O . HOH W 5 . ? 37.526 -25.680 -21.836 1.00 31.10 ? 2102 HOH A O 1 HETATM 4752 O O . HOH W 5 . ? 44.396 -24.655 -24.818 1.00 10.64 ? 2103 HOH A O 1 HETATM 4753 O O . HOH W 5 . ? 43.484 -21.766 -15.830 1.00 20.14 ? 2104 HOH A O 1 # loop_ _atom_site_anisotrop.id _atom_site_anisotrop.type_symbol _atom_site_anisotrop.pdbx_label_atom_id _atom_site_anisotrop.pdbx_label_alt_id _atom_site_anisotrop.pdbx_label_comp_id _atom_site_anisotrop.pdbx_label_asym_id _atom_site_anisotrop.pdbx_label_seq_id _atom_site_anisotrop.pdbx_PDB_ins_code _atom_site_anisotrop.U[1][1] _atom_site_anisotrop.U[2][2] _atom_site_anisotrop.U[3][3] _atom_site_anisotrop.U[1][2] _atom_site_anisotrop.U[1][3] _atom_site_anisotrop.U[2][3] _atom_site_anisotrop.pdbx_auth_seq_id _atom_site_anisotrop.pdbx_auth_comp_id _atom_site_anisotrop.pdbx_auth_asym_id _atom_site_anisotrop.pdbx_auth_atom_id 4617 CD CD . CD C . ? 0.4894 0.4256 0.3627 -0.0201 -0.0291 0.0325 1620 CD A CD 4618 CD CD . CD D . ? 0.4055 0.5225 0.5790 -0.0363 -0.0729 0.0931 1621 CD A CD 4619 CD CD . CD E . ? 0.3061 0.3704 0.3257 0.0028 -0.0118 0.0272 1622 CD A CD 4620 CD CD . CD F . ? 0.5827 0.4427 0.5604 0.0004 0.0464 -0.0430 1623 CD A CD 4621 CD CD . CD G . ? 1.2843 1.2220 1.1373 0.0157 0.0048 -0.0045 1624 CD A CD 4622 CD CD . CD H . ? 0.3858 0.2959 0.3223 -0.0945 -0.0028 -0.0339 1625 CD A CD 4623 CD CD . CD I . ? 0.9288 0.8489 0.8796 0.0384 0.0834 0.0265 1626 CD A CD 4624 CD CD . CD J . ? 0.5081 0.4950 0.6484 0.0337 -0.0250 0.0018 1627 CD A CD 4625 CD CD . CD K . ? 0.5836 0.3613 0.3462 0.0082 -0.0293 -0.0134 1628 CD A CD 4626 CD CD . CD L . ? 0.7890 0.7363 0.5183 -0.0342 0.0345 0.0670 1629 CD A CD 4627 CD CD . CD M . ? 0.4265 0.3333 0.3829 -0.0426 -0.0484 -0.0287 1630 CD A CD 4628 CD CD . CD N . ? 0.5269 0.4359 0.4710 0.0296 -0.0189 -0.0611 1631 CD A CD 4629 CD CD . CD O . ? 0.4684 0.6031 0.4051 0.1309 -0.0227 -0.0316 1632 CD A CD 4630 CD CD . CD P . ? 0.6993 0.6902 0.7352 -0.0459 0.0310 0.0068 1633 CD A CD 4631 CD CD . CD Q . ? 0.4965 0.5625 0.4727 -0.1731 0.0160 -0.0180 1634 CD A CD 4632 CD CD . CD R . ? 0.5993 0.6056 0.6545 0.2040 -0.0089 0.0709 1635 CD A CD 4633 CD CD . CD S . ? 0.7486 0.8085 0.9013 0.0447 -0.0992 0.0055 1636 CD A CD 4634 CD CD . CD T . ? 0.9311 0.7658 1.1849 -0.1290 0.0499 -0.0167 1637 CD A CD 4649 CD CD . CD V . ? 0.6353 0.7408 0.4147 -0.0060 -0.0966 0.0563 1409 CD T CD # loop_ _pdbx_poly_seq_scheme.asym_id _pdbx_poly_seq_scheme.entity_id _pdbx_poly_seq_scheme.seq_id _pdbx_poly_seq_scheme.mon_id _pdbx_poly_seq_scheme.ndb_seq_num _pdbx_poly_seq_scheme.pdb_seq_num _pdbx_poly_seq_scheme.auth_seq_num _pdbx_poly_seq_scheme.pdb_mon_id _pdbx_poly_seq_scheme.auth_mon_id _pdbx_poly_seq_scheme.pdb_strand_id _pdbx_poly_seq_scheme.pdb_ins_code _pdbx_poly_seq_scheme.hetero A 1 1 GLY 1 29 ? ? ? A . n A 1 2 SER 2 30 ? ? ? A . n A 1 3 VAL 3 31 ? ? ? A . n A 1 4 GLY 4 32 ? ? ? A . n A 1 5 PRO 5 33 ? ? ? A . n A 1 6 LYS 6 34 ? ? ? A . n A 1 7 THR 7 35 ? ? ? A . n A 1 8 GLY 8 36 ? ? ? A . n A 1 9 GLU 9 37 ? ? ? A . n A 1 10 GLU 10 38 ? ? ? A . n A 1 11 ASN 11 39 ? ? ? A . n A 1 12 GLN 12 40 40 GLN GLN A . n A 1 13 VAL 13 41 41 VAL VAL A . n A 1 14 LEU 14 42 42 LEU LEU A . n A 1 15 VAL 15 43 43 VAL VAL A . n A 1 16 PRO 16 44 44 PRO PRO A . n A 1 17 ASN 17 45 45 ASN ASN A . n A 1 18 LEU 18 46 46 LEU LEU A . n A 1 19 ASN 19 47 47 ASN ASN A . n A 1 20 PRO 20 48 48 PRO PRO A . n A 1 21 THR 21 49 49 THR THR A . n A 1 22 PRO 22 50 50 PRO PRO A . n A 1 23 GLU 23 51 51 GLU GLU A . n A 1 24 ASN 24 52 52 ASN ASN A . n A 1 25 LEU 25 53 53 LEU LEU A . n A 1 26 GLU 26 54 54 GLU GLU A . n A 1 27 VAL 27 55 55 VAL VAL A . n A 1 28 VAL 28 56 56 VAL VAL A . n A 1 29 GLY 29 57 57 GLY GLY A . n A 1 30 ASP 30 58 58 ASP ASP A . n A 1 31 GLY 31 59 59 GLY GLY A . n A 1 32 PHE 32 60 60 PHE PHE A . n A 1 33 LYS 33 61 61 LYS LYS A . n A 1 34 ILE 34 62 62 ILE ILE A . n A 1 35 THR 35 63 63 THR THR A . n A 1 36 SER 36 64 64 SER SER A . n A 1 37 SER 37 65 65 SER SER A . n A 1 38 ILE 38 66 66 ILE ILE A . n A 1 39 ASN 39 67 67 ASN ASN A . n A 1 40 LEU 40 68 68 LEU LEU A . n A 1 41 VAL 41 69 69 VAL VAL A . n A 1 42 GLY 42 70 70 GLY GLY A . n A 1 43 GLU 43 71 71 GLU GLU A . n A 1 44 GLU 44 72 72 GLU GLU A . n A 1 45 GLU 45 73 73 GLU GLU A . n A 1 46 ALA 46 74 74 ALA ALA A . n A 1 47 ASP 47 75 75 ASP ASP A . n A 1 48 GLU 48 76 76 GLU GLU A . n A 1 49 ASN 49 77 77 ASN ASN A . n A 1 50 ALA 50 78 78 ALA ALA A . n A 1 51 VAL 51 79 79 VAL VAL A . n A 1 52 ASN 52 80 80 ASN ASN A . n A 1 53 ALA 53 81 81 ALA ALA A . n A 1 54 LEU 54 82 82 LEU LEU A . n A 1 55 ARG 55 83 83 ARG ARG A . n A 1 56 GLU 56 84 84 GLU GLU A . n A 1 57 PHE 57 85 85 PHE PHE A . n A 1 58 LEU 58 86 86 LEU LEU A . n A 1 59 THR 59 87 87 THR THR A . n A 1 60 ALA 60 88 88 ALA ALA A . n A 1 61 ASN 61 89 89 ASN ASN A . n A 1 62 ASN 62 90 90 ASN ASN A . n A 1 63 ILE 63 91 91 ILE ILE A . n A 1 64 GLU 64 92 92 GLU GLU A . n A 1 65 ILE 65 93 93 ILE ILE A . n A 1 66 ASN 66 94 94 ASN ASN A . n A 1 67 SER 67 95 95 SER SER A . n A 1 68 GLU 68 96 96 GLU GLU A . n A 1 69 ASN 69 97 97 ASN ASN A . n A 1 70 ASP 70 98 98 ASP ASP A . n A 1 71 PRO 71 99 99 PRO PRO A . n A 1 72 ASN 72 100 100 ASN ASN A . n A 1 73 SER 73 101 101 SER SER A . n A 1 74 THR 74 102 102 THR THR A . n A 1 75 THR 75 103 103 THR THR A . n A 1 76 LEU 76 104 104 LEU LEU A . n A 1 77 ILE 77 105 105 ILE ILE A . n A 1 78 ILE 78 106 106 ILE ILE A . n A 1 79 GLY 79 107 107 GLY GLY A . n A 1 80 GLU 80 108 108 GLU GLU A . n A 1 81 VAL 81 109 109 VAL VAL A . n A 1 82 ASP 82 110 110 ASP ASP A . n A 1 83 ASP 83 111 111 ASP ASP A . n A 1 84 ASP 84 112 112 ASP ASP A . n A 1 85 ILE 85 113 113 ILE ILE A . n A 1 86 PRO 86 114 114 PRO PRO A . n A 1 87 GLU 87 115 115 GLU GLU A . n A 1 88 LEU 88 116 116 LEU LEU A . n A 1 89 ASP 89 117 117 ASP ASP A . n A 1 90 GLU 90 118 118 GLU GLU A . n A 1 91 ALA 91 119 119 ALA ALA A . n A 1 92 LEU 92 120 120 LEU LEU A . n A 1 93 ASN 93 121 121 ASN ASN A . n A 1 94 GLY 94 122 122 GLY GLY A . n A 1 95 THR 95 123 123 THR THR A . n A 1 96 THR 96 124 124 THR THR A . n A 1 97 ALA 97 125 125 ALA ALA A . n A 1 98 GLU 98 126 126 GLU GLU A . n A 1 99 ASN 99 127 127 ASN ASN A . n A 1 100 LEU 100 128 128 LEU LEU A . n A 1 101 LYS 101 129 129 LYS LYS A . n A 1 102 GLU 102 130 130 GLU GLU A . n A 1 103 GLU 103 131 131 GLU GLU A . n A 1 104 GLY 104 132 132 GLY GLY A . n A 1 105 TYR 105 133 133 TYR TYR A . n A 1 106 ALA 106 134 134 ALA ALA A . n A 1 107 LEU 107 135 135 LEU LEU A . n A 1 108 VAL 108 136 136 VAL VAL A . n A 1 109 SER 109 137 137 SER SER A . n A 1 110 ASN 110 138 138 ASN ASN A . n A 1 111 ASP 111 139 139 ASP ASP A . n A 1 112 GLY 112 140 140 GLY GLY A . n A 1 113 LYS 113 141 141 LYS LYS A . n A 1 114 ILE 114 142 142 ILE ILE A . n A 1 115 ALA 115 143 143 ALA ALA A . n A 1 116 ILE 116 144 144 ILE ILE A . n A 1 117 GLU 117 145 145 GLU GLU A . n A 1 118 GLY 118 146 146 GLY GLY A . n A 1 119 LYS 119 147 147 LYS LYS A . n A 1 120 ASP 120 148 148 ASP ASP A . n A 1 121 GLY 121 149 149 GLY GLY A . n A 1 122 ASP 122 150 150 ASP ASP A . n A 1 123 GLY 123 151 151 GLY GLY A . n A 1 124 THR 124 152 152 THR THR A . n A 1 125 PHE 125 153 153 PHE PHE A . n A 1 126 TYR 126 154 154 TYR TYR A . n A 1 127 GLY 127 155 155 GLY GLY A . n A 1 128 VAL 128 156 156 VAL VAL A . n A 1 129 GLN 129 157 157 GLN GLN A . n A 1 130 THR 130 158 158 THR THR A . n A 1 131 PHE 131 159 159 PHE PHE A . n A 1 132 LYS 132 160 160 LYS LYS A . n A 1 133 GLN 133 161 161 GLN GLN A . n A 1 134 LEU 134 162 162 LEU LEU A . n A 1 135 VAL 135 163 163 VAL VAL A . n A 1 136 LYS 136 164 164 LYS LYS A . n A 1 137 GLU 137 165 165 GLU GLU A . n A 1 138 SER 138 166 166 SER SER A . n A 1 139 ASN 139 167 167 ASN ASN A . n A 1 140 ILE 140 168 168 ILE ILE A . n A 1 141 PRO 141 169 169 PRO PRO A . n A 1 142 GLU 142 170 170 GLU GLU A . n A 1 143 VAL 143 171 171 VAL VAL A . n A 1 144 ASN 144 172 172 ASN ASN A . n A 1 145 ILE 145 173 173 ILE ILE A . n A 1 146 THR 146 174 174 THR THR A . n A 1 147 ASP 147 175 175 ASP ASP A . n A 1 148 TYR 148 176 176 TYR TYR A . n A 1 149 PRO 149 177 177 PRO PRO A . n A 1 150 THR 150 178 178 THR THR A . n A 1 151 VAL 151 179 179 VAL VAL A . n A 1 152 SER 152 180 180 SER SER A . n A 1 153 ALA 153 181 181 ALA ALA A . n A 1 154 ARG 154 182 182 ARG ARG A . n A 1 155 GLY 155 183 183 GLY GLY A . n A 1 156 ILE 156 184 184 ILE ILE A . n A 1 157 VAL 157 185 185 VAL VAL A . n A 1 158 GLU 158 186 186 GLU GLU A . n A 1 159 GLY 159 187 187 GLY GLY A . n A 1 160 PHE 160 188 188 PHE PHE A . n A 1 161 TYR 161 189 189 TYR TYR A . n A 1 162 GLY 162 190 190 GLY GLY A . n A 1 163 THR 163 191 191 THR THR A . n A 1 164 PRO 164 192 192 PRO PRO A . n A 1 165 TRP 165 193 193 TRP TRP A . n A 1 166 THR 166 194 194 THR THR A . n A 1 167 HIS 167 195 195 HIS HIS A . n A 1 168 GLN 168 196 196 GLN GLN A . n A 1 169 ASP 169 197 197 ASP ASP A . n A 1 170 ARG 170 198 198 ARG ARG A . n A 1 171 LEU 171 199 199 LEU LEU A . n A 1 172 ASP 172 200 200 ASP ASP A . n A 1 173 GLN 173 201 201 GLN GLN A . n A 1 174 ILE 174 202 202 ILE ILE A . n A 1 175 LYS 175 203 203 LYS LYS A . n A 1 176 PHE 176 204 204 PHE PHE A . n A 1 177 TYR 177 205 205 TYR TYR A . n A 1 178 GLY 178 206 206 GLY GLY A . n A 1 179 GLU 179 207 207 GLU GLU A . n A 1 180 ASN 180 208 208 ASN ASN A . n A 1 181 LYS 181 209 209 LYS LYS A . n A 1 182 LEU 182 210 210 LEU LEU A . n A 1 183 ASN 183 211 211 ASN ASN A . n A 1 184 THR 184 212 212 THR THR A . n A 1 185 TYR 185 213 213 TYR TYR A . n A 1 186 ILE 186 214 214 ILE ILE A . n A 1 187 TYR 187 215 215 TYR TYR A . n A 1 188 ALA 188 216 216 ALA ALA A . n A 1 189 PRO 189 217 217 PRO PRO A . n A 1 190 LYS 190 218 218 LYS LYS A . n A 1 191 ASP 191 219 219 ASP ASP A . n A 1 192 ASP 192 220 220 ASP ASP A . n A 1 193 PRO 193 221 221 PRO PRO A . n A 1 194 TYR 194 222 222 TYR TYR A . n A 1 195 HIS 195 223 223 HIS HIS A . n A 1 196 ARG 196 224 224 ARG ARG A . n A 1 197 GLU 197 225 225 GLU GLU A . n A 1 198 LYS 198 226 226 LYS LYS A . n A 1 199 TRP 199 227 227 TRP TRP A . n A 1 200 ARG 200 228 228 ARG ARG A . n A 1 201 GLU 201 229 229 GLU GLU A . n A 1 202 PRO 202 230 230 PRO PRO A . n A 1 203 TYR 203 231 231 TYR TYR A . n A 1 204 PRO 204 232 232 PRO PRO A . n A 1 205 GLU 205 233 233 GLU GLU A . n A 1 206 SER 206 234 234 SER SER A . n A 1 207 GLU 207 235 235 GLU GLU A . n A 1 208 MET 208 236 236 MET MET A . n A 1 209 GLN 209 237 237 GLN GLN A . n A 1 210 ARG 210 238 238 ARG ARG A . n A 1 211 MET 211 239 239 MET MET A . n A 1 212 GLN 212 240 240 GLN GLN A . n A 1 213 GLU 213 241 241 GLU GLU A . n A 1 214 LEU 214 242 242 LEU LEU A . n A 1 215 ILE 215 243 243 ILE ILE A . n A 1 216 ASN 216 244 244 ASN ASN A . n A 1 217 ALA 217 245 245 ALA ALA A . n A 1 218 SER 218 246 246 SER SER A . n A 1 219 ALA 219 247 247 ALA ALA A . n A 1 220 GLU 220 248 248 GLU GLU A . n A 1 221 ASN 221 249 249 ASN ASN A . n A 1 222 LYS 222 250 250 LYS LYS A . n A 1 223 VAL 223 251 251 VAL VAL A . n A 1 224 ASP 224 252 252 ASP ASP A . n A 1 225 PHE 225 253 253 PHE PHE A . n A 1 226 VAL 226 254 254 VAL VAL A . n A 1 227 PHE 227 255 255 PHE PHE A . n A 1 228 GLY 228 256 256 GLY GLY A . n A 1 229 ILE 229 257 257 ILE ILE A . n A 1 230 SER 230 258 258 SER SER A . n A 1 231 PRO 231 259 259 PRO PRO A . n A 1 232 GLY 232 260 260 GLY GLY A . n A 1 233 ILE 233 261 261 ILE ILE A . n A 1 234 ASP 234 262 262 ASP ASP A . n A 1 235 ILE 235 263 263 ILE ILE A . n A 1 236 ARG 236 264 264 ARG ARG A . n A 1 237 PHE 237 265 265 PHE PHE A . n A 1 238 ASP 238 266 266 ASP ASP A . n A 1 239 GLY 239 267 267 GLY GLY A . n A 1 240 ASP 240 268 268 ASP ASP A . n A 1 241 ALA 241 269 269 ALA ALA A . n A 1 242 GLY 242 270 270 GLY GLY A . n A 1 243 GLU 243 271 271 GLU GLU A . n A 1 244 GLU 244 272 272 GLU GLU A . n A 1 245 ASP 245 273 273 ASP ASP A . n A 1 246 PHE 246 274 274 PHE PHE A . n A 1 247 ASN 247 275 275 ASN ASN A . n A 1 248 HIS 248 276 276 HIS HIS A . n A 1 249 LEU 249 277 277 LEU LEU A . n A 1 250 ILE 250 278 278 ILE ILE A . n A 1 251 THR 251 279 279 THR THR A . n A 1 252 LYS 252 280 280 LYS LYS A . n A 1 253 ALA 253 281 281 ALA ALA A . n A 1 254 GLU 254 282 282 GLU GLU A . n A 1 255 SER 255 283 283 SER SER A . n A 1 256 LEU 256 284 284 LEU LEU A . n A 1 257 TYR 257 285 285 TYR TYR A . n A 1 258 ASP 258 286 286 ASP ASP A . n A 1 259 MET 259 287 287 MET MET A . n A 1 260 GLY 260 288 288 GLY GLY A . n A 1 261 VAL 261 289 289 VAL VAL A . n A 1 262 ARG 262 290 290 ARG ARG A . n A 1 263 SER 263 291 291 SER SER A . n A 1 264 PHE 264 292 292 PHE PHE A . n A 1 265 ALA 265 293 293 ALA ALA A . n A 1 266 ILE 266 294 294 ILE ILE A . n A 1 267 TYR 267 295 295 TYR TYR A . n A 1 268 TRP 268 296 296 TRP TRP A . n A 1 269 ASP 269 297 297 ASP ASP A . n A 1 270 ASN 270 298 298 ASN ASN A . n A 1 271 ILE 271 299 299 ILE ILE A . n A 1 272 GLN 272 300 300 GLN GLN A . n A 1 273 ASP 273 301 301 ASP ASP A . n A 1 274 LYS 274 302 302 LYS LYS A . n A 1 275 SER 275 303 303 SER SER A . n A 1 276 ALA 276 304 304 ALA ALA A . n A 1 277 ALA 277 305 305 ALA ALA A . n A 1 278 LYS 278 306 306 LYS LYS A . n A 1 279 HIS 279 307 307 HIS HIS A . n A 1 280 ALA 280 308 308 ALA ALA A . n A 1 281 GLN 281 309 309 GLN GLN A . n A 1 282 VAL 282 310 310 VAL VAL A . n A 1 283 LEU 283 311 311 LEU LEU A . n A 1 284 ASN 284 312 312 ASN ASN A . n A 1 285 ARG 285 313 313 ARG ARG A . n A 1 286 PHE 286 314 314 PHE PHE A . n A 1 287 ASN 287 315 315 ASN ASN A . n A 1 288 GLU 288 316 316 GLU GLU A . n A 1 289 GLU 289 317 317 GLU GLU A . n A 1 290 PHE 290 318 318 PHE PHE A . n A 1 291 VAL 291 319 319 VAL VAL A . n A 1 292 LYS 292 320 320 LYS LYS A . n A 1 293 ALA 293 321 321 ALA ALA A . n A 1 294 LYS 294 322 322 LYS LYS A . n A 1 295 GLY 295 323 323 GLY GLY A . n A 1 296 ASP 296 324 324 ASP ASP A . n A 1 297 VAL 297 325 325 VAL VAL A . n A 1 298 LYS 298 326 326 LYS LYS A . n A 1 299 PRO 299 327 327 PRO PRO A . n A 1 300 LEU 300 328 328 LEU LEU A . n A 1 301 ILE 301 329 329 ILE ILE A . n A 1 302 THR 302 330 330 THR THR A . n A 1 303 VAL 303 331 331 VAL VAL A . n A 1 304 PRO 304 332 332 PRO PRO A . n A 1 305 THR 305 333 333 THR THR A . n A 1 306 GLU 306 334 334 GLU GLU A . n A 1 307 TYR 307 335 335 TYR TYR A . n A 1 308 ASP 308 336 336 ASP ASP A . n A 1 309 THR 309 337 337 THR THR A . n A 1 310 GLY 310 338 338 GLY GLY A . n A 1 311 ALA 311 339 339 ALA ALA A . n A 1 312 MET 312 340 340 MET MET A . n A 1 313 VAL 313 341 341 VAL VAL A . n A 1 314 SER 314 342 342 SER SER A . n A 1 315 ASN 315 343 343 ASN ASN A . n A 1 316 GLY 316 344 344 GLY GLY A . n A 1 317 GLN 317 345 345 GLN GLN A . n A 1 318 PRO 318 346 346 PRO PRO A . n A 1 319 ARG 319 347 347 ARG ARG A . n A 1 320 ALA 320 348 348 ALA ALA A . n A 1 321 TYR 321 349 349 TYR TYR A . n A 1 322 THR 322 350 350 THR THR A . n A 1 323 ARG 323 351 351 ARG ARG A . n A 1 324 ILE 324 352 352 ILE ILE A . n A 1 325 PHE 325 353 353 PHE PHE A . n A 1 326 ALA 326 354 354 ALA ALA A . n A 1 327 GLU 327 355 355 GLU GLU A . n A 1 328 THR 328 356 356 THR THR A . n A 1 329 VAL 329 357 357 VAL VAL A . n A 1 330 ASP 330 358 358 ASP ASP A . n A 1 331 PRO 331 359 359 PRO PRO A . n A 1 332 SER 332 360 360 SER SER A . n A 1 333 ILE 333 361 361 ILE ILE A . n A 1 334 GLU 334 362 362 GLU GLU A . n A 1 335 VAL 335 363 363 VAL VAL A . n A 1 336 MET 336 364 364 MET MET A . n A 1 337 TRP 337 365 365 TRP TRP A . n A 1 338 THR 338 366 366 THR THR A . n A 1 339 GLY 339 367 367 GLY GLY A . n A 1 340 PRO 340 368 368 PRO PRO A . n A 1 341 GLY 341 369 369 GLY GLY A . n A 1 342 VAL 342 370 370 VAL VAL A . n A 1 343 VAL 343 371 371 VAL VAL A . n A 1 344 THR 344 372 372 THR THR A . n A 1 345 ASN 345 373 373 ASN ASN A . n A 1 346 GLU 346 374 374 GLU GLU A . n A 1 347 ILE 347 375 375 ILE ILE A . n A 1 348 PRO 348 376 376 PRO PRO A . n A 1 349 LEU 349 377 377 LEU LEU A . n A 1 350 SER 350 378 378 SER SER A . n A 1 351 ASP 351 379 379 ASP ASP A . n A 1 352 ALA 352 380 380 ALA ALA A . n A 1 353 GLN 353 381 381 GLN GLN A . n A 1 354 LEU 354 382 382 LEU LEU A . n A 1 355 ILE 355 383 383 ILE ILE A . n A 1 356 SER 356 384 384 SER SER A . n A 1 357 GLY 357 385 385 GLY GLY A . n A 1 358 ILE 358 386 386 ILE ILE A . n A 1 359 TYR 359 387 387 TYR TYR A . n A 1 360 ASP 360 388 388 ASP ASP A . n A 1 361 ARG 361 389 389 ARG ARG A . n A 1 362 ASN 362 390 390 ASN ASN A . n A 1 363 MET 363 391 391 MET MET A . n A 1 364 ALA 364 392 392 ALA ALA A . n A 1 365 VAL 365 393 393 VAL VAL A . n A 1 366 TRP 366 394 394 TRP TRP A . n A 1 367 TRP 367 395 395 TRP TRP A . n A 1 368 ASN 368 396 396 ASN ASN A . n A 1 369 TYR 369 397 397 TYR TYR A . n A 1 370 PRO 370 398 398 PRO PRO A . n A 1 371 VAL 371 399 399 VAL VAL A . n A 1 372 THR 372 400 400 THR THR A . n A 1 373 ASP 373 401 401 ASP ASP A . n A 1 374 TYR 374 402 402 TYR TYR A . n A 1 375 PHE 375 403 403 PHE PHE A . n A 1 376 LYS 376 404 404 LYS LYS A . n A 1 377 GLY 377 405 405 GLY GLY A . n A 1 378 LYS 378 406 406 LYS LYS A . n A 1 379 LEU 379 407 407 LEU LEU A . n A 1 380 ALA 380 408 408 ALA ALA A . n A 1 381 LEU 381 409 409 LEU LEU A . n A 1 382 GLY 382 410 410 GLY GLY A . n A 1 383 PRO 383 411 411 PRO PRO A . n A 1 384 MET 384 412 412 MET MET A . n A 1 385 HIS 385 413 413 HIS HIS A . n A 1 386 GLY 386 414 414 GLY GLY A . n A 1 387 LEU 387 415 415 LEU LEU A . n A 1 388 ASP 388 416 416 ASP ASP A . n A 1 389 LYS 389 417 417 LYS LYS A . n A 1 390 GLY 390 418 418 GLY GLY A . n A 1 391 LEU 391 419 419 LEU LEU A . n A 1 392 ASN 392 420 420 ASN ASN A . n A 1 393 GLN 393 421 421 GLN GLN A . n A 1 394 TYR 394 422 422 TYR TYR A . n A 1 395 VAL 395 423 423 VAL VAL A . n A 1 396 ASP 396 424 424 ASP ASP A . n A 1 397 PHE 397 425 425 PHE PHE A . n A 1 398 PHE 398 426 426 PHE PHE A . n A 1 399 THR 399 427 427 THR THR A . n A 1 400 VAL 400 428 428 VAL VAL A . n A 1 401 ASN 401 429 429 ASN ASN A . n A 1 402 PRO 402 430 430 PRO PRO A . n A 1 403 MET 403 431 431 MET MET A . n A 1 404 GLU 404 432 432 GLU GLU A . n A 1 405 HIS 405 433 433 HIS HIS A . n A 1 406 ALA 406 434 434 ALA ALA A . n A 1 407 GLU 407 435 435 GLU GLU A . n A 1 408 LEU 408 436 436 LEU LEU A . n A 1 409 SER 409 437 437 SER SER A . n A 1 410 LYS 410 438 438 LYS LYS A . n A 1 411 ILE 411 439 439 ILE ILE A . n A 1 412 SER 412 440 440 SER SER A . n A 1 413 ILE 413 441 441 ILE ILE A . n A 1 414 HIS 414 442 442 HIS HIS A . n A 1 415 THR 415 443 443 THR THR A . n A 1 416 ALA 416 444 444 ALA ALA A . n A 1 417 ALA 417 445 445 ALA ALA A . n A 1 418 ASP 418 446 446 ASP ASP A . n A 1 419 TYR 419 447 447 TYR TYR A . n A 1 420 SER 420 448 448 SER SER A . n A 1 421 TRP 421 449 449 TRP TRP A . n A 1 422 ASN 422 450 450 ASN ASN A . n A 1 423 MET 423 451 451 MET MET A . n A 1 424 ASP 424 452 452 ASP ASP A . n A 1 425 ASN 425 453 453 ASN ASN A . n A 1 426 TYR 426 454 454 TYR TYR A . n A 1 427 ASP 427 455 455 ASP ASP A . n A 1 428 TYR 428 456 456 TYR TYR A . n A 1 429 ASP 429 457 457 ASP ASP A . n A 1 430 LYS 430 458 458 LYS LYS A . n A 1 431 ALA 431 459 459 ALA ALA A . n A 1 432 TRP 432 460 460 TRP TRP A . n A 1 433 ASN 433 461 461 ASN ASN A . n A 1 434 ARG 434 462 462 ARG ARG A . n A 1 435 ALA 435 463 463 ALA ALA A . n A 1 436 ILE 436 464 464 ILE ILE A . n A 1 437 ASP 437 465 465 ASP ASP A . n A 1 438 MET 438 466 466 MET MET A . n A 1 439 LEU 439 467 467 LEU LEU A . n A 1 440 TYR 440 468 468 TYR TYR A . n A 1 441 GLY 441 469 469 GLY GLY A . n A 1 442 ASP 442 470 470 ASP ASP A . n A 1 443 LEU 443 471 471 LEU LEU A . n A 1 444 ALA 444 472 472 ALA ALA A . n A 1 445 GLU 445 473 473 GLU GLU A . n A 1 446 ASP 446 474 474 ASP ASP A . n A 1 447 MET 447 475 475 MET MET A . n A 1 448 LYS 448 476 476 LYS LYS A . n A 1 449 VAL 449 477 477 VAL VAL A . n A 1 450 PHE 450 478 478 PHE PHE A . n A 1 451 ALA 451 479 479 ALA ALA A . n A 1 452 ASN 452 480 480 ASN ASN A . n A 1 453 HIS 453 481 481 HIS HIS A . n A 1 454 SER 454 482 482 SER SER A . n A 1 455 THR 455 483 483 THR THR A . n A 1 456 ARG 456 484 484 ARG ARG A . n A 1 457 MET 457 485 485 MET MET A . n A 1 458 ASP 458 486 486 ASP ASP A . n A 1 459 ASN 459 487 487 ASN ASN A . n A 1 460 LYS 460 488 488 LYS LYS A . n A 1 461 THR 461 489 489 THR THR A . n A 1 462 TRP 462 490 490 TRP TRP A . n A 1 463 ALA 463 491 491 ALA ALA A . n A 1 464 LYS 464 492 492 LYS LYS A . n A 1 465 SER 465 493 493 SER SER A . n A 1 466 GLY 466 494 494 GLY GLY A . n A 1 467 ARG 467 495 495 ARG ARG A . n A 1 468 GLU 468 496 496 GLU GLU A . n A 1 469 ASP 469 497 497 ASP ASP A . n A 1 470 ALA 470 498 498 ALA ALA A . n A 1 471 PRO 471 499 499 PRO PRO A . n A 1 472 GLU 472 500 500 GLU GLU A . n A 1 473 LEU 473 501 501 LEU LEU A . n A 1 474 ARG 474 502 502 ARG ARG A . n A 1 475 ALA 475 503 503 ALA ALA A . n A 1 476 LYS 476 504 504 LYS LYS A . n A 1 477 MET 477 505 505 MET MET A . n A 1 478 ASP 478 506 506 ASP ASP A . n A 1 479 GLU 479 507 507 GLU GLU A . n A 1 480 LEU 480 508 508 LEU LEU A . n A 1 481 TRP 481 509 509 TRP TRP A . n A 1 482 ASN 482 510 510 ASN ASN A . n A 1 483 LYS 483 511 511 LYS LYS A . n A 1 484 LEU 484 512 512 LEU LEU A . n A 1 485 SER 485 513 513 SER SER A . n A 1 486 SER 486 514 514 SER SER A . n A 1 487 LYS 487 515 515 LYS LYS A . n A 1 488 GLU 488 516 516 GLU GLU A . n A 1 489 ASP 489 517 517 ASP ASP A . n A 1 490 ALA 490 518 518 ALA ALA A . n A 1 491 SER 491 519 519 SER SER A . n A 1 492 ALA 492 520 520 ALA ALA A . n A 1 493 LEU 493 521 521 LEU LEU A . n A 1 494 ILE 494 522 522 ILE ILE A . n A 1 495 GLU 495 523 523 GLU GLU A . n A 1 496 GLU 496 524 524 GLU GLU A . n A 1 497 LEU 497 525 525 LEU LEU A . n A 1 498 TYR 498 526 526 TYR TYR A . n A 1 499 GLY 499 527 527 GLY GLY A . n A 1 500 GLU 500 528 528 GLU GLU A . n A 1 501 PHE 501 529 529 PHE PHE A . n A 1 502 ALA 502 530 530 ALA ALA A . n A 1 503 ARG 503 531 531 ARG ARG A . n A 1 504 MET 504 532 532 MET MET A . n A 1 505 GLU 505 533 533 GLU GLU A . n A 1 506 GLU 506 534 534 GLU GLU A . n A 1 507 ALA 507 535 535 ALA ALA A . n A 1 508 CYS 508 536 536 CYS CYS A . n A 1 509 ASN 509 537 537 ASN ASN A . n A 1 510 ASN 510 538 538 ASN ASN A . n A 1 511 LEU 511 539 539 LEU LEU A . n A 1 512 LYS 512 540 540 LYS LYS A . n A 1 513 ALA 513 541 541 ALA ALA A . n A 1 514 ASN 514 542 542 ASN ASN A . n A 1 515 LEU 515 543 543 LEU LEU A . n A 1 516 PRO 516 544 544 PRO PRO A . n A 1 517 GLU 517 545 545 GLU GLU A . n A 1 518 VAL 518 546 546 VAL VAL A . n A 1 519 ALA 519 547 547 ALA ALA A . n A 1 520 LEU 520 548 548 LEU LEU A . n A 1 521 GLU 521 549 549 GLU GLU A . n A 1 522 GLU 522 550 550 GLU GLU A . n A 1 523 CYS 523 551 551 CYS CYS A . n A 1 524 SER 524 552 552 SER SER A . n A 1 525 ARG 525 553 553 ARG ARG A . n A 1 526 GLN 526 554 554 GLN GLN A . n A 1 527 LEU 527 555 555 LEU LEU A . n A 1 528 ASP 528 556 556 ASP ASP A . n A 1 529 GLU 529 557 557 GLU GLU A . n A 1 530 LEU 530 558 558 LEU LEU A . n A 1 531 ILE 531 559 559 ILE ILE A . n A 1 532 THR 532 560 560 THR THR A . n A 1 533 LEU 533 561 561 LEU LEU A . n A 1 534 ALA 534 562 562 ALA ALA A . n A 1 535 GLN 535 563 563 GLN GLN A . n A 1 536 GLY 536 564 564 GLY GLY A . n A 1 537 ASP 537 565 565 ASP ASP A . n A 1 538 LYS 538 566 566 LYS LYS A . n A 1 539 ALA 539 567 567 ALA ALA A . n A 1 540 SER 540 568 568 SER SER A . n A 1 541 LEU 541 569 569 LEU LEU A . n A 1 542 ASP 542 570 570 ASP ASP A . n A 1 543 MET 543 571 571 MET MET A . n A 1 544 ILE 544 572 572 ILE ILE A . n A 1 545 VAL 545 573 573 VAL VAL A . n A 1 546 ALA 546 574 574 ALA ALA A . n A 1 547 GLN 547 575 575 GLN GLN A . n A 1 548 LEU 548 576 576 LEU LEU A . n A 1 549 ASN 549 577 577 ASN ASN A . n A 1 550 GLU 550 578 578 GLU GLU A . n A 1 551 ASP 551 579 579 ASP ASP A . n A 1 552 THR 552 580 580 THR THR A . n A 1 553 GLU 553 581 581 GLU GLU A . n A 1 554 ALA 554 582 582 ALA ALA A . n A 1 555 TYR 555 583 583 TYR TYR A . n A 1 556 GLU 556 584 584 GLU GLU A . n A 1 557 SER 557 585 585 SER SER A . n A 1 558 ALA 558 586 586 ALA ALA A . n A 1 559 LYS 559 587 587 LYS LYS A . n A 1 560 GLU 560 588 588 GLU GLU A . n A 1 561 ILE 561 589 589 ILE ILE A . n A 1 562 ALA 562 590 590 ALA ALA A . n A 1 563 GLN 563 591 591 GLN GLN A . n A 1 564 ASN 564 592 592 ASN ASN A . n A 1 565 LYS 565 593 593 LYS LYS A . n A 1 566 LEU 566 594 594 LEU LEU A . n A 1 567 ASN 567 595 595 ASN ASN A . n A 1 568 THR 568 596 596 THR THR A . n A 1 569 ALA 569 597 597 ALA ALA A . n A 1 570 LEU 570 598 598 LEU LEU A . n A 1 571 SER 571 599 599 SER SER A . n A 1 572 SER 572 600 600 SER SER A . n A 1 573 PHE 573 601 601 PHE PHE A . n A 1 574 ALA 574 602 602 ALA ALA A . n A 1 575 VAL 575 603 603 VAL VAL A . n A 1 576 ILE 576 604 604 ILE ILE A . n A 1 577 SER 577 605 605 SER SER A . n A 1 578 GLU 578 606 606 GLU GLU A . n A 1 579 LYS 579 607 607 LYS LYS A . n A 1 580 VAL 580 608 608 VAL VAL A . n A 1 581 ALA 581 609 609 ALA ALA A . n A 1 582 GLN 582 610 610 GLN GLN A . n A 1 583 SER 583 611 611 SER SER A . n A 1 584 PHE 584 612 612 PHE PHE A . n A 1 585 ILE 585 613 613 ILE ILE A . n A 1 586 GLN 586 614 614 GLN GLN A . n A 1 587 GLU 587 615 615 GLU GLU A . n A 1 588 ALA 588 616 616 ALA ALA A . n A 1 589 LEU 589 617 617 LEU LEU A . n A 1 590 SER 590 618 618 SER SER A . n B 2 1 VAL 1 402 402 VAL VAL T . n B 2 2 ALA 2 403 403 ALA ALA T . n B 2 3 HIS 3 404 404 HIS HIS T . n B 2 4 SER 4 405 405 SER SER T . n B 2 5 GLY 5 406 406 GLY GLY T . n B 2 6 ALA 6 407 407 ALA ALA T . n B 2 7 LYS 7 408 408 LYS LYS T . n # loop_ _pdbx_nonpoly_scheme.asym_id _pdbx_nonpoly_scheme.entity_id _pdbx_nonpoly_scheme.mon_id _pdbx_nonpoly_scheme.ndb_seq_num _pdbx_nonpoly_scheme.pdb_seq_num _pdbx_nonpoly_scheme.auth_seq_num _pdbx_nonpoly_scheme.pdb_mon_id _pdbx_nonpoly_scheme.auth_mon_id _pdbx_nonpoly_scheme.pdb_strand_id _pdbx_nonpoly_scheme.pdb_ins_code C 3 CD 1 1620 1620 CD CD A . D 3 CD 1 1621 1621 CD CD A . E 3 CD 1 1622 1622 CD CD A . F 3 CD 1 1623 1623 CD CD A . G 3 CD 1 1624 1624 CD CD A . H 3 CD 1 1625 1625 CD CD A . I 3 CD 1 1626 1626 CD CD A . J 3 CD 1 1627 1627 CD CD A . K 3 CD 1 1628 1628 CD CD A . L 3 CD 1 1629 1629 CD CD A . M 3 CD 1 1630 1630 CD CD A . N 3 CD 1 1631 1631 CD CD A . O 3 CD 1 1632 1632 CD CD A . P 3 CD 1 1633 1633 CD CD A . Q 3 CD 1 1634 1634 CD CD A . R 3 CD 1 1635 1635 CD CD A . S 3 CD 1 1636 1636 CD CD A . T 3 CD 1 1637 1637 CD CD A . U 4 NAG 1 500 500 NAG NAG T . V 3 CD 1 1409 1409 CD CD T . W 5 HOH 1 2001 2001 HOH HOH A . W 5 HOH 2 2002 2002 HOH HOH A . W 5 HOH 3 2003 2003 HOH HOH A . W 5 HOH 4 2004 2004 HOH HOH A . W 5 HOH 5 2005 2005 HOH HOH A . W 5 HOH 6 2006 2006 HOH HOH A . W 5 HOH 7 2007 2007 HOH HOH A . W 5 HOH 8 2008 2008 HOH HOH A . W 5 HOH 9 2009 2009 HOH HOH A . W 5 HOH 10 2010 2010 HOH HOH A . W 5 HOH 11 2011 2011 HOH HOH A . W 5 HOH 12 2012 2012 HOH HOH A . W 5 HOH 13 2013 2013 HOH HOH A . W 5 HOH 14 2014 2014 HOH HOH A . W 5 HOH 15 2015 2015 HOH HOH A . W 5 HOH 16 2016 2016 HOH HOH A . W 5 HOH 17 2017 2017 HOH HOH A . W 5 HOH 18 2018 2018 HOH HOH A . W 5 HOH 19 2019 2019 HOH HOH A . W 5 HOH 20 2020 2020 HOH HOH A . W 5 HOH 21 2021 2021 HOH HOH A . W 5 HOH 22 2022 2022 HOH HOH A . W 5 HOH 23 2023 2023 HOH HOH A . W 5 HOH 24 2024 2024 HOH HOH A . W 5 HOH 25 2025 2025 HOH HOH A . W 5 HOH 26 2026 2026 HOH HOH A . W 5 HOH 27 2027 2027 HOH HOH A . W 5 HOH 28 2028 2028 HOH HOH A . W 5 HOH 29 2029 2029 HOH HOH A . W 5 HOH 30 2030 2030 HOH HOH A . W 5 HOH 31 2031 2031 HOH HOH A . W 5 HOH 32 2032 2032 HOH HOH A . W 5 HOH 33 2033 2033 HOH HOH A . W 5 HOH 34 2034 2034 HOH HOH A . W 5 HOH 35 2035 2035 HOH HOH A . W 5 HOH 36 2036 2036 HOH HOH A . W 5 HOH 37 2037 2037 HOH HOH A . W 5 HOH 38 2038 2038 HOH HOH A . W 5 HOH 39 2039 2039 HOH HOH A . W 5 HOH 40 2040 2040 HOH HOH A . W 5 HOH 41 2041 2041 HOH HOH A . W 5 HOH 42 2042 2042 HOH HOH A . W 5 HOH 43 2043 2043 HOH HOH A . W 5 HOH 44 2044 2044 HOH HOH A . W 5 HOH 45 2045 2045 HOH HOH A . W 5 HOH 46 2046 2046 HOH HOH A . W 5 HOH 47 2047 2047 HOH HOH A . W 5 HOH 48 2048 2048 HOH HOH A . W 5 HOH 49 2049 2049 HOH HOH A . W 5 HOH 50 2050 2050 HOH HOH A . W 5 HOH 51 2051 2051 HOH HOH A . W 5 HOH 52 2052 2052 HOH HOH A . W 5 HOH 53 2053 2053 HOH HOH A . W 5 HOH 54 2054 2054 HOH HOH A . W 5 HOH 55 2055 2055 HOH HOH A . W 5 HOH 56 2056 2056 HOH HOH A . W 5 HOH 57 2057 2057 HOH HOH A . W 5 HOH 58 2058 2058 HOH HOH A . W 5 HOH 59 2059 2059 HOH HOH A . W 5 HOH 60 2060 2060 HOH HOH A . W 5 HOH 61 2061 2061 HOH HOH A . W 5 HOH 62 2062 2062 HOH HOH A . W 5 HOH 63 2063 2063 HOH HOH A . W 5 HOH 64 2064 2064 HOH HOH A . W 5 HOH 65 2065 2065 HOH HOH A . W 5 HOH 66 2066 2066 HOH HOH A . W 5 HOH 67 2067 2067 HOH HOH A . W 5 HOH 68 2068 2068 HOH HOH A . W 5 HOH 69 2069 2069 HOH HOH A . W 5 HOH 70 2070 2070 HOH HOH A . W 5 HOH 71 2071 2071 HOH HOH A . W 5 HOH 72 2072 2072 HOH HOH A . W 5 HOH 73 2073 2073 HOH HOH A . W 5 HOH 74 2074 2074 HOH HOH A . W 5 HOH 75 2075 2075 HOH HOH A . W 5 HOH 76 2076 2076 HOH HOH A . W 5 HOH 77 2077 2077 HOH HOH A . W 5 HOH 78 2078 2078 HOH HOH A . W 5 HOH 79 2079 2079 HOH HOH A . W 5 HOH 80 2080 2080 HOH HOH A . W 5 HOH 81 2081 2081 HOH HOH A . W 5 HOH 82 2082 2082 HOH HOH A . W 5 HOH 83 2083 2083 HOH HOH A . W 5 HOH 84 2084 2084 HOH HOH A . W 5 HOH 85 2085 2085 HOH HOH A . W 5 HOH 86 2086 2086 HOH HOH A . W 5 HOH 87 2087 2087 HOH HOH A . W 5 HOH 88 2088 2088 HOH HOH A . W 5 HOH 89 2089 2089 HOH HOH A . W 5 HOH 90 2090 2090 HOH HOH A . W 5 HOH 91 2091 2091 HOH HOH A . W 5 HOH 92 2092 2092 HOH HOH A . W 5 HOH 93 2093 2093 HOH HOH A . W 5 HOH 94 2094 2094 HOH HOH A . W 5 HOH 95 2095 2095 HOH HOH A . W 5 HOH 96 2096 2096 HOH HOH A . W 5 HOH 97 2097 2097 HOH HOH A . W 5 HOH 98 2098 2098 HOH HOH A . W 5 HOH 99 2099 2099 HOH HOH A . W 5 HOH 100 2100 2100 HOH HOH A . W 5 HOH 101 2101 2101 HOH HOH A . W 5 HOH 102 2102 2102 HOH HOH A . W 5 HOH 103 2103 2103 HOH HOH A . W 5 HOH 104 2104 2104 HOH HOH A . # _pdbx_struct_mod_residue.id 1 _pdbx_struct_mod_residue.label_asym_id B _pdbx_struct_mod_residue.label_comp_id SER _pdbx_struct_mod_residue.label_seq_id 4 _pdbx_struct_mod_residue.auth_asym_id T _pdbx_struct_mod_residue.auth_comp_id SER _pdbx_struct_mod_residue.auth_seq_id 405 _pdbx_struct_mod_residue.PDB_ins_code ? _pdbx_struct_mod_residue.parent_comp_id SER _pdbx_struct_mod_residue.details 'GLYCOSYLATION SITE' # _pdbx_struct_assembly.id 1 _pdbx_struct_assembly.details author_and_software_defined_assembly _pdbx_struct_assembly.method_details PISA _pdbx_struct_assembly.oligomeric_details dimeric _pdbx_struct_assembly.oligomeric_count 2 # _pdbx_struct_assembly_gen.assembly_id 1 _pdbx_struct_assembly_gen.oper_expression 1 _pdbx_struct_assembly_gen.asym_id_list A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R,S,T,U,V,W # loop_ _pdbx_struct_assembly_prop.biol_id _pdbx_struct_assembly_prop.type _pdbx_struct_assembly_prop.value _pdbx_struct_assembly_prop.details 1 'ABSA (A^2)' 1030 ? 1 MORE -5.0 ? 1 'SSA (A^2)' 29660 ? # _pdbx_struct_oper_list.id 1 _pdbx_struct_oper_list.type 'identity operation' _pdbx_struct_oper_list.name 1_555 _pdbx_struct_oper_list.symmetry_operation x,y,z _pdbx_struct_oper_list.matrix[1][1] 1.0000000000 _pdbx_struct_oper_list.matrix[1][2] 0.0000000000 _pdbx_struct_oper_list.matrix[1][3] 0.0000000000 _pdbx_struct_oper_list.vector[1] 0.0000000000 _pdbx_struct_oper_list.matrix[2][1] 0.0000000000 _pdbx_struct_oper_list.matrix[2][2] 1.0000000000 _pdbx_struct_oper_list.matrix[2][3] 0.0000000000 _pdbx_struct_oper_list.vector[2] 0.0000000000 _pdbx_struct_oper_list.matrix[3][1] 0.0000000000 _pdbx_struct_oper_list.matrix[3][2] 0.0000000000 _pdbx_struct_oper_list.matrix[3][3] 1.0000000000 _pdbx_struct_oper_list.vector[3] 0.0000000000 # loop_ _pdbx_struct_conn_angle.id _pdbx_struct_conn_angle.ptnr1_label_atom_id _pdbx_struct_conn_angle.ptnr1_label_alt_id _pdbx_struct_conn_angle.ptnr1_label_asym_id _pdbx_struct_conn_angle.ptnr1_label_comp_id _pdbx_struct_conn_angle.ptnr1_label_seq_id _pdbx_struct_conn_angle.ptnr1_auth_atom_id _pdbx_struct_conn_angle.ptnr1_auth_asym_id _pdbx_struct_conn_angle.ptnr1_auth_comp_id _pdbx_struct_conn_angle.ptnr1_auth_seq_id _pdbx_struct_conn_angle.ptnr1_PDB_ins_code _pdbx_struct_conn_angle.ptnr1_symmetry _pdbx_struct_conn_angle.ptnr2_label_atom_id _pdbx_struct_conn_angle.ptnr2_label_alt_id _pdbx_struct_conn_angle.ptnr2_label_asym_id _pdbx_struct_conn_angle.ptnr2_label_comp_id _pdbx_struct_conn_angle.ptnr2_label_seq_id _pdbx_struct_conn_angle.ptnr2_auth_atom_id _pdbx_struct_conn_angle.ptnr2_auth_asym_id _pdbx_struct_conn_angle.ptnr2_auth_comp_id _pdbx_struct_conn_angle.ptnr2_auth_seq_id _pdbx_struct_conn_angle.ptnr2_PDB_ins_code _pdbx_struct_conn_angle.ptnr2_symmetry _pdbx_struct_conn_angle.ptnr3_label_atom_id _pdbx_struct_conn_angle.ptnr3_label_alt_id _pdbx_struct_conn_angle.ptnr3_label_asym_id _pdbx_struct_conn_angle.ptnr3_label_comp_id _pdbx_struct_conn_angle.ptnr3_label_seq_id _pdbx_struct_conn_angle.ptnr3_auth_atom_id _pdbx_struct_conn_angle.ptnr3_auth_asym_id _pdbx_struct_conn_angle.ptnr3_auth_comp_id _pdbx_struct_conn_angle.ptnr3_auth_seq_id _pdbx_struct_conn_angle.ptnr3_PDB_ins_code _pdbx_struct_conn_angle.ptnr3_symmetry _pdbx_struct_conn_angle.value _pdbx_struct_conn_angle.value_esd 1 OE2 ? A GLU 23 ? A GLU 51 ? 1_555 CD ? O CD . ? A CD 1632 ? 1_555 OD1 ? A ASP 424 ? A ASP 452 ? 1_555 150.6 ? 2 OE2 ? A GLU 23 ? A GLU 51 ? 1_555 CD ? O CD . ? A CD 1632 ? 1_555 O ? W HOH . ? A HOH 2086 ? 1_555 95.4 ? 3 OD1 ? A ASP 424 ? A ASP 452 ? 1_555 CD ? O CD . ? A CD 1632 ? 1_555 O ? W HOH . ? A HOH 2086 ? 1_555 90.4 ? 4 OE2 ? A GLU 23 ? A GLU 51 ? 1_555 CD ? O CD . ? A CD 1632 ? 1_555 OE1 ? A GLU 23 ? A GLU 51 ? 1_555 54.2 ? 5 OD1 ? A ASP 424 ? A ASP 452 ? 1_555 CD ? O CD . ? A CD 1632 ? 1_555 OE1 ? A GLU 23 ? A GLU 51 ? 1_555 149.1 ? 6 O ? W HOH . ? A HOH 2086 ? 1_555 CD ? O CD . ? A CD 1632 ? 1_555 OE1 ? A GLU 23 ? A GLU 51 ? 1_555 108.2 ? 7 OE2 ? A GLU 23 ? A GLU 51 ? 1_555 CD ? O CD . ? A CD 1632 ? 1_555 OD1 ? A ASN 422 ? A ASN 450 ? 1_555 86.1 ? 8 OD1 ? A ASP 424 ? A ASP 452 ? 1_555 CD ? O CD . ? A CD 1632 ? 1_555 OD1 ? A ASN 422 ? A ASN 450 ? 1_555 84.8 ? 9 O ? W HOH . ? A HOH 2086 ? 1_555 CD ? O CD . ? A CD 1632 ? 1_555 OD1 ? A ASN 422 ? A ASN 450 ? 1_555 172.7 ? 10 OE1 ? A GLU 23 ? A GLU 51 ? 1_555 CD ? O CD . ? A CD 1632 ? 1_555 OD1 ? A ASN 422 ? A ASN 450 ? 1_555 78.5 ? 11 OE1 ? A GLU 517 ? A GLU 545 ? 2_545 CD ? C CD . ? A CD 1620 ? 1_555 O ? W HOH . ? A HOH 2025 ? 1_555 95.4 ? 12 OE1 ? A GLU 517 ? A GLU 545 ? 2_545 CD ? C CD . ? A CD 1620 ? 1_555 OD1 ? A ASP 89 ? A ASP 117 ? 1_555 149.9 ? 13 O ? W HOH . ? A HOH 2025 ? 1_555 CD ? C CD . ? A CD 1620 ? 1_555 OD1 ? A ASP 89 ? A ASP 117 ? 1_555 107.8 ? 14 OE1 ? A GLU 517 ? A GLU 545 ? 2_545 CD ? C CD . ? A CD 1620 ? 1_555 OD2 ? A ASP 89 ? A ASP 117 ? 1_555 105.9 ? 15 O ? W HOH . ? A HOH 2025 ? 1_555 CD ? C CD . ? A CD 1620 ? 1_555 OD2 ? A ASP 89 ? A ASP 117 ? 1_555 114.1 ? 16 OD1 ? A ASP 89 ? A ASP 117 ? 1_555 CD ? C CD . ? A CD 1620 ? 1_555 OD2 ? A ASP 89 ? A ASP 117 ? 1_555 47.3 ? 17 OE1 ? A GLU 517 ? A GLU 545 ? 2_545 CD ? C CD . ? A CD 1620 ? 1_555 OE2 ? A GLU 117 ? A GLU 145 ? 1_555 103.4 ? 18 O ? W HOH . ? A HOH 2025 ? 1_555 CD ? C CD . ? A CD 1620 ? 1_555 OE2 ? A GLU 117 ? A GLU 145 ? 1_555 90.0 ? 19 OD1 ? A ASP 89 ? A ASP 117 ? 1_555 CD ? C CD . ? A CD 1620 ? 1_555 OE2 ? A GLU 117 ? A GLU 145 ? 1_555 95.6 ? 20 OD2 ? A ASP 89 ? A ASP 117 ? 1_555 CD ? C CD . ? A CD 1620 ? 1_555 OE2 ? A GLU 117 ? A GLU 145 ? 1_555 139.5 ? 21 OE1 ? A GLU 517 ? A GLU 545 ? 2_545 CD ? C CD . ? A CD 1620 ? 1_555 OE2 ? A GLU 517 ? A GLU 545 ? 2_545 56.2 ? 22 O ? W HOH . ? A HOH 2025 ? 1_555 CD ? C CD . ? A CD 1620 ? 1_555 OE2 ? A GLU 517 ? A GLU 545 ? 2_545 147.6 ? 23 OD1 ? A ASP 89 ? A ASP 117 ? 1_555 CD ? C CD . ? A CD 1620 ? 1_555 OE2 ? A GLU 517 ? A GLU 545 ? 2_545 95.5 ? 24 OD2 ? A ASP 89 ? A ASP 117 ? 1_555 CD ? C CD . ? A CD 1620 ? 1_555 OE2 ? A GLU 517 ? A GLU 545 ? 2_545 66.4 ? 25 OE2 ? A GLU 117 ? A GLU 145 ? 1_555 CD ? C CD . ? A CD 1620 ? 1_555 OE2 ? A GLU 517 ? A GLU 545 ? 2_545 110.2 ? 26 OE1 ? A GLU 517 ? A GLU 545 ? 2_545 CD ? C CD . ? A CD 1620 ? 1_555 O ? W HOH . ? A HOH 2022 ? 1_555 77.7 ? 27 O ? W HOH . ? A HOH 2025 ? 1_555 CD ? C CD . ? A CD 1620 ? 1_555 O ? W HOH . ? A HOH 2022 ? 1_555 71.8 ? 28 OD1 ? A ASP 89 ? A ASP 117 ? 1_555 CD ? C CD . ? A CD 1620 ? 1_555 O ? W HOH . ? A HOH 2022 ? 1_555 91.4 ? 29 OD2 ? A ASP 89 ? A ASP 117 ? 1_555 CD ? C CD . ? A CD 1620 ? 1_555 O ? W HOH . ? A HOH 2022 ? 1_555 54.3 ? 30 OE2 ? A GLU 117 ? A GLU 145 ? 1_555 CD ? C CD . ? A CD 1620 ? 1_555 O ? W HOH . ? A HOH 2022 ? 1_555 161.7 ? 31 OE2 ? A GLU 517 ? A GLU 545 ? 2_545 CD ? C CD . ? A CD 1620 ? 1_555 O ? W HOH . ? A HOH 2022 ? 1_555 85.8 ? 32 O ? W HOH . ? A HOH 2055 ? 6_555 CD ? D CD . ? A CD 1621 ? 1_555 OD2 ? A ASP 111 ? A ASP 139 ? 1_555 117.1 ? 33 O ? W HOH . ? A HOH 2055 ? 6_555 CD ? D CD . ? A CD 1621 ? 1_555 OD1 ? A ASP 111 ? A ASP 139 ? 1_555 108.9 ? 34 OD2 ? A ASP 111 ? A ASP 139 ? 1_555 CD ? D CD . ? A CD 1621 ? 1_555 OD1 ? A ASP 111 ? A ASP 139 ? 1_555 53.6 ? 35 O ? W HOH . ? A HOH 2055 ? 6_555 CD ? D CD . ? A CD 1621 ? 1_555 OD2 ? A ASP 240 ? A ASP 268 ? 6_555 88.7 ? 36 OD2 ? A ASP 111 ? A ASP 139 ? 1_555 CD ? D CD . ? A CD 1621 ? 1_555 OD2 ? A ASP 240 ? A ASP 268 ? 6_555 133.8 ? 37 OD1 ? A ASP 111 ? A ASP 139 ? 1_555 CD ? D CD . ? A CD 1621 ? 1_555 OD2 ? A ASP 240 ? A ASP 268 ? 6_555 82.9 ? 38 O ? W HOH . ? A HOH 2055 ? 6_555 CD ? D CD . ? A CD 1621 ? 1_555 O ? W HOH . ? A HOH 2031 ? 1_555 164.6 ? 39 OD2 ? A ASP 111 ? A ASP 139 ? 1_555 CD ? D CD . ? A CD 1621 ? 1_555 O ? W HOH . ? A HOH 2031 ? 1_555 76.8 ? 40 OD1 ? A ASP 111 ? A ASP 139 ? 1_555 CD ? D CD . ? A CD 1621 ? 1_555 O ? W HOH . ? A HOH 2031 ? 1_555 84.3 ? 41 OD2 ? A ASP 240 ? A ASP 268 ? 6_555 CD ? D CD . ? A CD 1621 ? 1_555 O ? W HOH . ? A HOH 2031 ? 1_555 85.1 ? 42 OE2 ? A GLU 254 ? A GLU 282 ? 1_555 CD ? E CD . ? A CD 1622 ? 1_555 OD2 ? A ASP 258 ? A ASP 286 ? 1_555 99.5 ? 43 OE2 ? A GLU 254 ? A GLU 282 ? 1_555 CD ? E CD . ? A CD 1622 ? 1_555 O ? W HOH . ? A HOH 2059 ? 1_555 97.8 ? 44 OD2 ? A ASP 258 ? A ASP 286 ? 1_555 CD ? E CD . ? A CD 1622 ? 1_555 O ? W HOH . ? A HOH 2059 ? 1_555 81.8 ? 45 OE2 ? A GLU 254 ? A GLU 282 ? 1_555 CD ? E CD . ? A CD 1622 ? 1_555 OE1 ? A GLU 560 ? A GLU 588 ? 2_545 92.9 ? 46 OD2 ? A ASP 258 ? A ASP 286 ? 1_555 CD ? E CD . ? A CD 1622 ? 1_555 OE1 ? A GLU 560 ? A GLU 588 ? 2_545 160.6 ? 47 O ? W HOH . ? A HOH 2059 ? 1_555 CD ? E CD . ? A CD 1622 ? 1_555 OE1 ? A GLU 560 ? A GLU 588 ? 2_545 81.7 ? 48 OE2 ? A GLU 254 ? A GLU 282 ? 1_555 CD ? E CD . ? A CD 1622 ? 1_555 OE2 ? A GLU 560 ? A GLU 588 ? 2_545 85.4 ? 49 OD2 ? A ASP 258 ? A ASP 286 ? 1_555 CD ? E CD . ? A CD 1622 ? 1_555 OE2 ? A GLU 560 ? A GLU 588 ? 2_545 144.0 ? 50 O ? W HOH . ? A HOH 2059 ? 1_555 CD ? E CD . ? A CD 1622 ? 1_555 OE2 ? A GLU 560 ? A GLU 588 ? 2_545 133.2 ? 51 OE1 ? A GLU 560 ? A GLU 588 ? 2_545 CD ? E CD . ? A CD 1622 ? 1_555 OE2 ? A GLU 560 ? A GLU 588 ? 2_545 51.5 ? 52 OE2 ? A GLU 254 ? A GLU 282 ? 1_555 CD ? E CD . ? A CD 1622 ? 1_555 O ? W HOH . ? A HOH 2101 ? 2_545 167.6 ? 53 OD2 ? A ASP 258 ? A ASP 286 ? 1_555 CD ? E CD . ? A CD 1622 ? 1_555 O ? W HOH . ? A HOH 2101 ? 2_545 82.3 ? 54 O ? W HOH . ? A HOH 2059 ? 1_555 CD ? E CD . ? A CD 1622 ? 1_555 O ? W HOH . ? A HOH 2101 ? 2_545 94.5 ? 55 OE1 ? A GLU 560 ? A GLU 588 ? 2_545 CD ? E CD . ? A CD 1622 ? 1_555 O ? W HOH . ? A HOH 2101 ? 2_545 88.9 ? 56 OE2 ? A GLU 560 ? A GLU 588 ? 2_545 CD ? E CD . ? A CD 1622 ? 1_555 O ? W HOH . ? A HOH 2101 ? 2_545 86.1 ? 57 OE2 ? A GLU 254 ? A GLU 282 ? 1_555 CD ? E CD . ? A CD 1622 ? 1_555 OD1 ? A ASP 258 ? A ASP 286 ? 1_555 89.0 ? 58 OD2 ? A ASP 258 ? A ASP 286 ? 1_555 CD ? E CD . ? A CD 1622 ? 1_555 OD1 ? A ASP 258 ? A ASP 286 ? 1_555 54.2 ? 59 O ? W HOH . ? A HOH 2059 ? 1_555 CD ? E CD . ? A CD 1622 ? 1_555 OD1 ? A ASP 258 ? A ASP 286 ? 1_555 135.9 ? 60 OE1 ? A GLU 560 ? A GLU 588 ? 2_545 CD ? E CD . ? A CD 1622 ? 1_555 OD1 ? A ASP 258 ? A ASP 286 ? 1_555 141.7 ? 61 OE2 ? A GLU 560 ? A GLU 588 ? 2_545 CD ? E CD . ? A CD 1622 ? 1_555 OD1 ? A ASP 258 ? A ASP 286 ? 1_555 90.6 ? 62 O ? W HOH . ? A HOH 2101 ? 2_545 CD ? E CD . ? A CD 1622 ? 1_555 OD1 ? A ASP 258 ? A ASP 286 ? 1_555 82.1 ? 63 OD1 ? A ASP 30 ? A ASP 58 ? 1_555 CD ? F CD . ? A CD 1623 ? 1_555 OD2 ? A ASP 30 ? A ASP 58 ? 1_555 49.3 ? 64 OD1 ? A ASP 30 ? A ASP 58 ? 1_555 CD ? F CD . ? A CD 1623 ? 1_555 OE2 ? A GLU 244 ? A GLU 272 ? 6_555 100.2 ? 65 OD2 ? A ASP 30 ? A ASP 58 ? 1_555 CD ? F CD . ? A CD 1623 ? 1_555 OE2 ? A GLU 244 ? A GLU 272 ? 6_555 146.2 ? 66 OD1 ? A ASP 30 ? A ASP 58 ? 1_555 CD ? F CD . ? A CD 1623 ? 1_555 O ? W HOH . ? A HOH 2007 ? 1_555 127.6 ? 67 OD2 ? A ASP 30 ? A ASP 58 ? 1_555 CD ? F CD . ? A CD 1623 ? 1_555 O ? W HOH . ? A HOH 2007 ? 1_555 79.2 ? 68 OE2 ? A GLU 244 ? A GLU 272 ? 6_555 CD ? F CD . ? A CD 1623 ? 1_555 O ? W HOH . ? A HOH 2007 ? 1_555 125.0 ? 69 OD1 ? A ASP 30 ? A ASP 58 ? 1_555 CD ? F CD . ? A CD 1623 ? 1_555 O ? W HOH . ? A HOH 2008 ? 1_555 77.5 ? 70 OD2 ? A ASP 30 ? A ASP 58 ? 1_555 CD ? F CD . ? A CD 1623 ? 1_555 O ? W HOH . ? A HOH 2008 ? 1_555 100.0 ? 71 OE2 ? A GLU 244 ? A GLU 272 ? 6_555 CD ? F CD . ? A CD 1623 ? 1_555 O ? W HOH . ? A HOH 2008 ? 1_555 83.9 ? 72 O ? W HOH . ? A HOH 2007 ? 1_555 CD ? F CD . ? A CD 1623 ? 1_555 O ? W HOH . ? A HOH 2008 ? 1_555 127.3 ? 73 OD1 ? A ASP 30 ? A ASP 58 ? 1_555 CD ? F CD . ? A CD 1623 ? 1_555 OE1 ? A GLU 244 ? A GLU 272 ? 6_555 86.7 ? 74 OD2 ? A ASP 30 ? A ASP 58 ? 1_555 CD ? F CD . ? A CD 1623 ? 1_555 OE1 ? A GLU 244 ? A GLU 272 ? 6_555 105.1 ? 75 OE2 ? A GLU 244 ? A GLU 272 ? 6_555 CD ? F CD . ? A CD 1623 ? 1_555 OE1 ? A GLU 244 ? A GLU 272 ? 6_555 51.9 ? 76 O ? W HOH . ? A HOH 2007 ? 1_555 CD ? F CD . ? A CD 1623 ? 1_555 OE1 ? A GLU 244 ? A GLU 272 ? 6_555 100.4 ? 77 O ? W HOH . ? A HOH 2008 ? 1_555 CD ? F CD . ? A CD 1623 ? 1_555 OE1 ? A GLU 244 ? A GLU 272 ? 6_555 129.4 ? 78 OE1 ? A GLU 26 ? A GLU 54 ? 5_554 CD ? G CD . ? A CD 1624 ? 1_555 OE2 ? A GLU 26 ? A GLU 54 ? 5_554 45.0 ? 79 OE1 ? A GLU 26 ? A GLU 54 ? 5_554 CD ? G CD . ? A CD 1624 ? 1_555 OD2 ? A ASP 238 ? A ASP 266 ? 1_555 55.8 ? 80 OE2 ? A GLU 26 ? A GLU 54 ? 5_554 CD ? G CD . ? A CD 1624 ? 1_555 OD2 ? A ASP 238 ? A ASP 266 ? 1_555 92.9 ? 81 OE2 ? A GLU 522 ? A GLU 550 ? 2_545 CD ? H CD . ? A CD 1625 ? 1_555 OD2 ? A ASP 84 ? A ASP 112 ? 1_555 110.5 ? 82 OE2 ? A GLU 522 ? A GLU 550 ? 2_545 CD ? H CD . ? A CD 1625 ? 1_555 O ? W HOH . ? A HOH 2020 ? 1_555 166.9 ? 83 OD2 ? A ASP 84 ? A ASP 112 ? 1_555 CD ? H CD . ? A CD 1625 ? 1_555 O ? W HOH . ? A HOH 2020 ? 1_555 80.4 ? 84 OE2 ? A GLU 522 ? A GLU 550 ? 2_545 CD ? H CD . ? A CD 1625 ? 1_555 O ? W HOH . ? A HOH 2097 ? 2_545 91.4 ? 85 OD2 ? A ASP 84 ? A ASP 112 ? 1_555 CD ? H CD . ? A CD 1625 ? 1_555 O ? W HOH . ? A HOH 2097 ? 2_545 90.9 ? 86 O ? W HOH . ? A HOH 2020 ? 1_555 CD ? H CD . ? A CD 1625 ? 1_555 O ? W HOH . ? A HOH 2097 ? 2_545 95.7 ? 87 OE2 ? A GLU 522 ? A GLU 550 ? 2_545 CD ? H CD . ? A CD 1625 ? 1_555 O ? W HOH . ? A HOH 2098 ? 2_545 84.2 ? 88 OD2 ? A ASP 84 ? A ASP 112 ? 1_555 CD ? H CD . ? A CD 1625 ? 1_555 O ? W HOH . ? A HOH 2098 ? 2_545 85.4 ? 89 O ? W HOH . ? A HOH 2020 ? 1_555 CD ? H CD . ? A CD 1625 ? 1_555 O ? W HOH . ? A HOH 2098 ? 2_545 89.8 ? 90 O ? W HOH . ? A HOH 2097 ? 2_545 CD ? H CD . ? A CD 1625 ? 1_555 O ? W HOH . ? A HOH 2098 ? 2_545 172.8 ? 91 OE1 ? A GLU 553 ? A GLU 581 ? 1_555 CD ? I CD . ? A CD 1626 ? 1_555 OE1 ? A GLU 243 ? A GLU 271 ? 3_654 110.6 ? 92 O ? A LEU 40 ? A LEU 68 ? 1_555 CD ? J CD . ? A CD 1627 ? 1_555 OE1 ? A GLU 43 ? A GLU 71 ? 1_555 82.7 ? 93 O ? A LEU 40 ? A LEU 68 ? 1_555 CD ? J CD . ? A CD 1627 ? 1_555 OE2 ? A GLU 43 ? A GLU 71 ? 1_555 106.9 ? 94 OE1 ? A GLU 43 ? A GLU 71 ? 1_555 CD ? J CD . ? A CD 1627 ? 1_555 OE2 ? A GLU 43 ? A GLU 71 ? 1_555 50.0 ? 95 O ? A LEU 40 ? A LEU 68 ? 1_555 CD ? J CD . ? A CD 1627 ? 1_555 O ? W HOH . ? A HOH 2012 ? 1_555 74.5 ? 96 OE1 ? A GLU 43 ? A GLU 71 ? 1_555 CD ? J CD . ? A CD 1627 ? 1_555 O ? W HOH . ? A HOH 2012 ? 1_555 124.8 ? 97 OE2 ? A GLU 43 ? A GLU 71 ? 1_555 CD ? J CD . ? A CD 1627 ? 1_555 O ? W HOH . ? A HOH 2012 ? 1_555 89.8 ? 98 O ? A LEU 40 ? A LEU 68 ? 1_555 CD ? J CD . ? A CD 1627 ? 1_555 O ? W HOH . ? A HOH 2014 ? 1_555 108.9 ? 99 OE1 ? A GLU 43 ? A GLU 71 ? 1_555 CD ? J CD . ? A CD 1627 ? 1_555 O ? W HOH . ? A HOH 2014 ? 1_555 71.2 ? 100 OE2 ? A GLU 43 ? A GLU 71 ? 1_555 CD ? J CD . ? A CD 1627 ? 1_555 O ? W HOH . ? A HOH 2014 ? 1_555 103.8 ? 101 O ? W HOH . ? A HOH 2012 ? 1_555 CD ? J CD . ? A CD 1627 ? 1_555 O ? W HOH . ? A HOH 2014 ? 1_555 163.9 ? 102 O ? A GLU 45 ? A GLU 73 ? 1_555 CD ? K CD . ? A CD 1628 ? 1_555 O ? W HOH . ? A HOH 2015 ? 1_555 87.8 ? 103 O ? A GLU 45 ? A GLU 73 ? 1_555 CD ? K CD . ? A CD 1628 ? 1_555 OE1 ? A GLU 80 ? A GLU 108 ? 1_555 106.9 ? 104 O ? W HOH . ? A HOH 2015 ? 1_555 CD ? K CD . ? A CD 1628 ? 1_555 OE1 ? A GLU 80 ? A GLU 108 ? 1_555 98.1 ? 105 O ? A GLU 45 ? A GLU 73 ? 1_555 CD ? K CD . ? A CD 1628 ? 1_555 OD1 ? A ASP 83 ? A ASP 111 ? 1_555 98.3 ? 106 O ? W HOH . ? A HOH 2015 ? 1_555 CD ? K CD . ? A CD 1628 ? 1_555 OD1 ? A ASP 83 ? A ASP 111 ? 1_555 150.5 ? 107 OE1 ? A GLU 80 ? A GLU 108 ? 1_555 CD ? K CD . ? A CD 1628 ? 1_555 OD1 ? A ASP 83 ? A ASP 111 ? 1_555 107.5 ? 108 O ? A GLU 45 ? A GLU 73 ? 1_555 CD ? K CD . ? A CD 1628 ? 1_555 OD2 ? A ASP 83 ? A ASP 111 ? 1_555 70.4 ? 109 O ? W HOH . ? A HOH 2015 ? 1_555 CD ? K CD . ? A CD 1628 ? 1_555 OD2 ? A ASP 83 ? A ASP 111 ? 1_555 155.2 ? 110 OE1 ? A GLU 80 ? A GLU 108 ? 1_555 CD ? K CD . ? A CD 1628 ? 1_555 OD2 ? A ASP 83 ? A ASP 111 ? 1_555 78.1 ? 111 OD1 ? A ASP 83 ? A ASP 111 ? 1_555 CD ? K CD . ? A CD 1628 ? 1_555 OD2 ? A ASP 83 ? A ASP 111 ? 1_555 49.1 ? 112 O ? A GLU 45 ? A GLU 73 ? 1_555 CD ? K CD . ? A CD 1628 ? 1_555 O ? W HOH . ? A HOH 2019 ? 1_555 176.9 ? 113 O ? W HOH . ? A HOH 2015 ? 1_555 CD ? K CD . ? A CD 1628 ? 1_555 O ? W HOH . ? A HOH 2019 ? 1_555 90.2 ? 114 OE1 ? A GLU 80 ? A GLU 108 ? 1_555 CD ? K CD . ? A CD 1628 ? 1_555 O ? W HOH . ? A HOH 2019 ? 1_555 75.7 ? 115 OD1 ? A ASP 83 ? A ASP 111 ? 1_555 CD ? K CD . ? A CD 1628 ? 1_555 O ? W HOH . ? A HOH 2019 ? 1_555 82.3 ? 116 OD2 ? A ASP 83 ? A ASP 111 ? 1_555 CD ? K CD . ? A CD 1628 ? 1_555 O ? W HOH . ? A HOH 2019 ? 1_555 112.1 ? 117 O ? W HOH . ? A HOH 2032 ? 1_555 CD ? L CD . ? A CD 1629 ? 1_555 O ? W HOH . ? A HOH 2033 ? 1_555 97.5 ? 118 O ? W HOH . ? A HOH 2032 ? 1_555 CD ? L CD . ? A CD 1629 ? 1_555 OD1 ? A ASP 224 ? A ASP 252 ? 1_555 133.1 ? 119 O ? W HOH . ? A HOH 2033 ? 1_555 CD ? L CD . ? A CD 1629 ? 1_555 OD1 ? A ASP 224 ? A ASP 252 ? 1_555 116.9 ? 120 O ? W HOH . ? A HOH 2030 ? 1_555 CD ? M CD . ? A CD 1630 ? 1_555 OE2 ? A GLU 142 ? A GLU 170 ? 1_555 75.7 ? 121 O ? W HOH . ? A HOH 2030 ? 1_555 CD ? M CD . ? A CD 1630 ? 1_555 O ? W HOH . ? A HOH 2011 ? 1_555 161.1 ? 122 OE2 ? A GLU 142 ? A GLU 170 ? 1_555 CD ? M CD . ? A CD 1630 ? 1_555 O ? W HOH . ? A HOH 2011 ? 1_555 88.4 ? 123 O ? W HOH . ? A HOH 2030 ? 1_555 CD ? M CD . ? A CD 1630 ? 1_555 O ? W HOH . ? A HOH 2010 ? 1_555 90.6 ? 124 OE2 ? A GLU 142 ? A GLU 170 ? 1_555 CD ? M CD . ? A CD 1630 ? 1_555 O ? W HOH . ? A HOH 2010 ? 1_555 150.5 ? 125 O ? W HOH . ? A HOH 2011 ? 1_555 CD ? M CD . ? A CD 1630 ? 1_555 O ? W HOH . ? A HOH 2010 ? 1_555 98.9 ? 126 O ? W HOH . ? A HOH 2030 ? 1_555 CD ? M CD . ? A CD 1630 ? 1_555 OE1 ? A GLU 142 ? A GLU 170 ? 1_555 84.5 ? 127 OE2 ? A GLU 142 ? A GLU 170 ? 1_555 CD ? M CD . ? A CD 1630 ? 1_555 OE1 ? A GLU 142 ? A GLU 170 ? 1_555 51.8 ? 128 O ? W HOH . ? A HOH 2011 ? 1_555 CD ? M CD . ? A CD 1630 ? 1_555 OE1 ? A GLU 142 ? A GLU 170 ? 1_555 77.6 ? 129 O ? W HOH . ? A HOH 2010 ? 1_555 CD ? M CD . ? A CD 1630 ? 1_555 OE1 ? A GLU 142 ? A GLU 170 ? 1_555 101.7 ? 130 OE1 ? A GLU 334 ? A GLU 362 ? 1_555 CD ? N CD . ? A CD 1631 ? 1_555 OE2 ? A GLU 334 ? A GLU 362 ? 1_555 56.5 ? 131 OE1 ? A GLU 334 ? A GLU 362 ? 1_555 CD ? N CD . ? A CD 1631 ? 1_555 O ? W HOH . ? A HOH 2081 ? 1_555 103.1 ? 132 OE2 ? A GLU 334 ? A GLU 362 ? 1_555 CD ? N CD . ? A CD 1631 ? 1_555 O ? W HOH . ? A HOH 2081 ? 1_555 82.4 ? 133 OE1 ? A GLU 334 ? A GLU 362 ? 1_555 CD ? N CD . ? A CD 1631 ? 1_555 OD1 ? A ASP 396 ? A ASP 424 ? 1_555 90.0 ? 134 OE2 ? A GLU 334 ? A GLU 362 ? 1_555 CD ? N CD . ? A CD 1631 ? 1_555 OD1 ? A ASP 396 ? A ASP 424 ? 1_555 139.8 ? 135 O ? W HOH . ? A HOH 2081 ? 1_555 CD ? N CD . ? A CD 1631 ? 1_555 OD1 ? A ASP 396 ? A ASP 424 ? 1_555 84.9 ? 136 OE1 ? A GLU 334 ? A GLU 362 ? 1_555 CD ? N CD . ? A CD 1631 ? 1_555 OD2 ? A ASP 396 ? A ASP 424 ? 1_555 142.0 ? 137 OE2 ? A GLU 334 ? A GLU 362 ? 1_555 CD ? N CD . ? A CD 1631 ? 1_555 OD2 ? A ASP 396 ? A ASP 424 ? 1_555 150.6 ? 138 O ? W HOH . ? A HOH 2081 ? 1_555 CD ? N CD . ? A CD 1631 ? 1_555 OD2 ? A ASP 396 ? A ASP 424 ? 1_555 71.6 ? 139 OD1 ? A ASP 396 ? A ASP 424 ? 1_555 CD ? N CD . ? A CD 1631 ? 1_555 OD2 ? A ASP 396 ? A ASP 424 ? 1_555 52.4 ? 140 OE1 ? A GLU 334 ? A GLU 362 ? 1_555 CD ? N CD . ? A CD 1631 ? 1_555 O ? W HOH . ? A HOH 2073 ? 1_555 78.4 ? 141 OE2 ? A GLU 334 ? A GLU 362 ? 1_555 CD ? N CD . ? A CD 1631 ? 1_555 O ? W HOH . ? A HOH 2073 ? 1_555 92.8 ? 142 O ? W HOH . ? A HOH 2081 ? 1_555 CD ? N CD . ? A CD 1631 ? 1_555 O ? W HOH . ? A HOH 2073 ? 1_555 172.9 ? 143 OD1 ? A ASP 396 ? A ASP 424 ? 1_555 CD ? N CD . ? A CD 1631 ? 1_555 O ? W HOH . ? A HOH 2073 ? 1_555 102.1 ? 144 OD2 ? A ASP 396 ? A ASP 424 ? 1_555 CD ? N CD . ? A CD 1631 ? 1_555 O ? W HOH . ? A HOH 2073 ? 1_555 111.6 ? 145 OE1 ? A GLU 506 ? A GLU 534 ? 1_555 CD ? P CD . ? A CD 1633 ? 1_555 OD2 ? A ASP 446 ? A ASP 474 ? 1_555 112.5 ? 146 OE1 ? A GLU 506 ? A GLU 534 ? 1_555 CD ? P CD . ? A CD 1633 ? 1_555 OE2 ? A GLU 506 ? A GLU 534 ? 1_555 47.9 ? 147 OD2 ? A ASP 446 ? A ASP 474 ? 1_555 CD ? P CD . ? A CD 1633 ? 1_555 OE2 ? A GLU 506 ? A GLU 534 ? 1_555 113.1 ? 148 OE1 ? A GLU 506 ? A GLU 534 ? 1_555 CD ? P CD . ? A CD 1633 ? 1_555 OD1 ? A ASP 446 ? A ASP 474 ? 1_555 91.3 ? 149 OD2 ? A ASP 446 ? A ASP 474 ? 1_555 CD ? P CD . ? A CD 1633 ? 1_555 OD1 ? A ASP 446 ? A ASP 474 ? 1_555 52.3 ? 150 OE2 ? A GLU 506 ? A GLU 534 ? 1_555 CD ? P CD . ? A CD 1633 ? 1_555 OD1 ? A ASP 446 ? A ASP 474 ? 1_555 131.5 ? 151 NE2 ? A HIS 248 ? A HIS 276 ? 1_555 CD ? Q CD . ? A CD 1634 ? 1_555 OE2 ? A GLU 244 ? A GLU 272 ? 1_555 108.7 ? 152 O ? A LYS 376 ? A LYS 404 ? 1_555 CD ? S CD . ? A CD 1636 ? 1_555 O ? W HOH . ? A HOH 2075 ? 1_555 84.1 ? 153 O ? A LYS 376 ? A LYS 404 ? 1_555 CD ? S CD . ? A CD 1636 ? 1_555 NE2 ? A HIS 405 ? A HIS 433 ? 1_555 158.6 ? 154 O ? W HOH . ? A HOH 2075 ? 1_555 CD ? S CD . ? A CD 1636 ? 1_555 NE2 ? A HIS 405 ? A HIS 433 ? 1_555 87.5 ? 155 OE2 ? A GLU 521 ? A GLU 549 ? 2_545 CD ? T CD . ? A CD 1637 ? 1_555 OD2 ? A ASP 89 ? A ASP 117 ? 1_555 161.3 ? 156 OE2 ? A GLU 521 ? A GLU 549 ? 2_545 CD ? T CD . ? A CD 1637 ? 1_555 OE2 ? A GLU 517 ? A GLU 545 ? 2_545 103.8 ? 157 OD2 ? A ASP 89 ? A ASP 117 ? 1_555 CD ? T CD . ? A CD 1637 ? 1_555 OE2 ? A GLU 517 ? A GLU 545 ? 2_545 60.0 ? 158 OE2 ? A GLU 521 ? A GLU 549 ? 2_545 CD ? T CD . ? A CD 1637 ? 1_555 OE1 ? A GLU 521 ? A GLU 549 ? 2_545 50.1 ? 159 OD2 ? A ASP 89 ? A ASP 117 ? 1_555 CD ? T CD . ? A CD 1637 ? 1_555 OE1 ? A GLU 521 ? A GLU 549 ? 2_545 118.2 ? 160 OE2 ? A GLU 517 ? A GLU 545 ? 2_545 CD ? T CD . ? A CD 1637 ? 1_555 OE1 ? A GLU 521 ? A GLU 549 ? 2_545 59.7 ? # _pdbx_audit_revision_history.ordinal 1 _pdbx_audit_revision_history.data_content_type 'Structure model' _pdbx_audit_revision_history.major_revision 1 _pdbx_audit_revision_history.minor_revision 0 _pdbx_audit_revision_history.revision_date 2012-03-14 # _pdbx_audit_revision_details.ordinal 1 _pdbx_audit_revision_details.revision_ordinal 1 _pdbx_audit_revision_details.data_content_type 'Structure model' _pdbx_audit_revision_details.provider repository _pdbx_audit_revision_details.type 'Initial release' _pdbx_audit_revision_details.description ? # loop_ _software.name _software.classification _software.version _software.citation_id _software.pdbx_ordinal REFMAC refinement 5.5.0088 ? 1 MOSFLM 'data reduction' . ? 2 SCALA 'data scaling' . ? 3 # _pdbx_database_remark.id 700 _pdbx_database_remark.text ; SHEET DETERMINATION METHOD: DSSP THE SHEETS PRESENTED AS "AC" IN EACH CHAIN ON SHEET RECORDS BELOW IS ACTUALLY AN 8-STRANDED BARREL THIS IS REPRESENTED BY A 9-STRANDED SHEET IN WHICH THE FIRST AND LAST STRANDS ARE IDENTICAL. ; # _pdbx_entry_details.entry_id 2YDQ _pdbx_entry_details.compound_details ;ENGINEERED RESIDUE IN CHAIN A, ASP 298 TO ASN ENGINEERED RESIDUE IN CHAIN A, ASN 388 TO ASP ; _pdbx_entry_details.source_details ? _pdbx_entry_details.nonpolymer_details ? _pdbx_entry_details.sequence_details ? # _pdbx_validate_close_contact.id 1 _pdbx_validate_close_contact.PDB_model_num 1 _pdbx_validate_close_contact.auth_atom_id_1 OD1 _pdbx_validate_close_contact.auth_asym_id_1 A _pdbx_validate_close_contact.auth_comp_id_1 ASP _pdbx_validate_close_contact.auth_seq_id_1 150 _pdbx_validate_close_contact.PDB_ins_code_1 ? _pdbx_validate_close_contact.label_alt_id_1 ? _pdbx_validate_close_contact.auth_atom_id_2 O _pdbx_validate_close_contact.auth_asym_id_2 A _pdbx_validate_close_contact.auth_comp_id_2 HOH _pdbx_validate_close_contact.auth_seq_id_2 2032 _pdbx_validate_close_contact.PDB_ins_code_2 ? _pdbx_validate_close_contact.label_alt_id_2 ? _pdbx_validate_close_contact.dist 2.12 # _pdbx_validate_rmsd_bond.id 1 _pdbx_validate_rmsd_bond.PDB_model_num 1 _pdbx_validate_rmsd_bond.auth_atom_id_1 C _pdbx_validate_rmsd_bond.auth_asym_id_1 A _pdbx_validate_rmsd_bond.auth_comp_id_1 GLU _pdbx_validate_rmsd_bond.auth_seq_id_1 96 _pdbx_validate_rmsd_bond.PDB_ins_code_1 ? _pdbx_validate_rmsd_bond.label_alt_id_1 ? _pdbx_validate_rmsd_bond.auth_atom_id_2 N _pdbx_validate_rmsd_bond.auth_asym_id_2 A _pdbx_validate_rmsd_bond.auth_comp_id_2 ASN _pdbx_validate_rmsd_bond.auth_seq_id_2 97 _pdbx_validate_rmsd_bond.PDB_ins_code_2 ? _pdbx_validate_rmsd_bond.label_alt_id_2 ? _pdbx_validate_rmsd_bond.bond_value 1.174 _pdbx_validate_rmsd_bond.bond_target_value 1.336 _pdbx_validate_rmsd_bond.bond_deviation -0.162 _pdbx_validate_rmsd_bond.bond_standard_deviation 0.023 _pdbx_validate_rmsd_bond.linker_flag Y # loop_ _pdbx_validate_torsion.id _pdbx_validate_torsion.PDB_model_num _pdbx_validate_torsion.auth_comp_id _pdbx_validate_torsion.auth_asym_id _pdbx_validate_torsion.auth_seq_id _pdbx_validate_torsion.PDB_ins_code _pdbx_validate_torsion.label_alt_id _pdbx_validate_torsion.phi _pdbx_validate_torsion.psi 1 1 ASN A 97 ? ? -24.11 137.69 2 1 GLU A 131 ? ? 81.08 -4.45 3 1 SER A 166 ? ? 76.33 -7.80 4 1 THR A 191 ? ? -57.66 108.30 5 1 ALA A 216 ? ? -155.84 50.06 6 1 ARG A 224 ? ? -143.37 -74.39 7 1 ASP A 262 ? ? -145.70 13.41 8 1 PHE A 318 ? ? -122.09 -68.14 9 1 PHE A 403 ? ? -164.42 70.38 10 1 LYS A 488 ? ? 78.52 -11.34 11 1 THR A 489 ? ? -117.18 -105.84 12 1 ALA A 498 ? ? 18.82 70.16 13 1 LYS A 515 ? ? 37.66 30.59 14 1 VAL A 608 ? ? -124.31 -86.22 15 1 ALA T 407 ? ? -91.61 -143.24 # _pdbx_validate_polymer_linkage.id 1 _pdbx_validate_polymer_linkage.PDB_model_num 1 _pdbx_validate_polymer_linkage.auth_atom_id_1 C _pdbx_validate_polymer_linkage.auth_asym_id_1 A _pdbx_validate_polymer_linkage.auth_comp_id_1 GLU _pdbx_validate_polymer_linkage.auth_seq_id_1 96 _pdbx_validate_polymer_linkage.PDB_ins_code_1 ? _pdbx_validate_polymer_linkage.label_alt_id_1 ? _pdbx_validate_polymer_linkage.auth_atom_id_2 N _pdbx_validate_polymer_linkage.auth_asym_id_2 A _pdbx_validate_polymer_linkage.auth_comp_id_2 ASN _pdbx_validate_polymer_linkage.auth_seq_id_2 97 _pdbx_validate_polymer_linkage.PDB_ins_code_2 ? _pdbx_validate_polymer_linkage.label_alt_id_2 ? _pdbx_validate_polymer_linkage.dist 1.17 # loop_ _pdbx_unobs_or_zero_occ_atoms.id _pdbx_unobs_or_zero_occ_atoms.PDB_model_num _pdbx_unobs_or_zero_occ_atoms.polymer_flag _pdbx_unobs_or_zero_occ_atoms.occupancy_flag _pdbx_unobs_or_zero_occ_atoms.auth_asym_id _pdbx_unobs_or_zero_occ_atoms.auth_comp_id _pdbx_unobs_or_zero_occ_atoms.auth_seq_id _pdbx_unobs_or_zero_occ_atoms.PDB_ins_code _pdbx_unobs_or_zero_occ_atoms.auth_atom_id _pdbx_unobs_or_zero_occ_atoms.label_alt_id _pdbx_unobs_or_zero_occ_atoms.label_asym_id _pdbx_unobs_or_zero_occ_atoms.label_comp_id _pdbx_unobs_or_zero_occ_atoms.label_seq_id _pdbx_unobs_or_zero_occ_atoms.label_atom_id 1 1 Y 0 A GLU 96 ? C ? A GLU 68 C 2 1 Y 0 A GLU 96 ? O ? A GLU 68 O 3 1 Y 0 A GLU 115 ? CG ? A GLU 87 CG 4 1 Y 0 A GLU 115 ? CD ? A GLU 87 CD 5 1 Y 0 A GLU 115 ? OE1 ? A GLU 87 OE1 6 1 Y 0 A GLU 115 ? OE2 ? A GLU 87 OE2 7 1 Y 1 T LYS 408 ? CA ? B LYS 7 CA 8 1 Y 1 T LYS 408 ? C ? B LYS 7 C 9 1 Y 1 T LYS 408 ? O ? B LYS 7 O 10 1 Y 1 T LYS 408 ? CB ? B LYS 7 CB 11 1 Y 1 T LYS 408 ? CG ? B LYS 7 CG 12 1 Y 1 T LYS 408 ? CD ? B LYS 7 CD 13 1 Y 1 T LYS 408 ? CE ? B LYS 7 CE 14 1 Y 1 T LYS 408 ? NZ ? B LYS 7 NZ # loop_ _pdbx_unobs_or_zero_occ_residues.id _pdbx_unobs_or_zero_occ_residues.PDB_model_num _pdbx_unobs_or_zero_occ_residues.polymer_flag _pdbx_unobs_or_zero_occ_residues.occupancy_flag _pdbx_unobs_or_zero_occ_residues.auth_asym_id _pdbx_unobs_or_zero_occ_residues.auth_comp_id _pdbx_unobs_or_zero_occ_residues.auth_seq_id _pdbx_unobs_or_zero_occ_residues.PDB_ins_code _pdbx_unobs_or_zero_occ_residues.label_asym_id _pdbx_unobs_or_zero_occ_residues.label_comp_id _pdbx_unobs_or_zero_occ_residues.label_seq_id 1 1 Y 1 A GLY 29 ? A GLY 1 2 1 Y 1 A SER 30 ? A SER 2 3 1 Y 1 A VAL 31 ? A VAL 3 4 1 Y 1 A GLY 32 ? A GLY 4 5 1 Y 1 A PRO 33 ? A PRO 5 6 1 Y 1 A LYS 34 ? A LYS 6 7 1 Y 1 A THR 35 ? A THR 7 8 1 Y 1 A GLY 36 ? A GLY 8 9 1 Y 1 A GLU 37 ? A GLU 9 10 1 Y 1 A GLU 38 ? A GLU 10 11 1 Y 1 A ASN 39 ? A ASN 11 # loop_ _pdbx_entity_nonpoly.entity_id _pdbx_entity_nonpoly.name _pdbx_entity_nonpoly.comp_id 3 'CADMIUM ION' CD 4 N-ACETYL-D-GLUCOSAMINE NAG 5 water HOH #