data_2HRH # _entry.id 2HRH # _audit_conform.dict_name mmcif_pdbx.dic _audit_conform.dict_version 5.279 _audit_conform.dict_location http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic # loop_ _database_2.database_id _database_2.database_code PDB 2HRH RCSB RCSB038676 WWPDB D_1000038676 # _pdbx_database_related.db_name PDB _pdbx_database_related.db_id 2HRG _pdbx_database_related.details . _pdbx_database_related.content_type unspecified # _pdbx_database_status.status_code REL _pdbx_database_status.entry_id 2HRH _pdbx_database_status.recvd_initial_deposition_date 2006-07-20 _pdbx_database_status.deposit_site RCSB _pdbx_database_status.process_site PDBJ _pdbx_database_status.status_code_sf REL _pdbx_database_status.status_code_mr ? _pdbx_database_status.SG_entry ? _pdbx_database_status.status_code_cs ? _pdbx_database_status.methods_development_category ? _pdbx_database_status.pdb_format_compatible Y # loop_ _audit_author.name _audit_author.pdbx_ordinal 'Matera, I.' 1 'Gullotto, A.' 2 'Ferraroni, M.' 3 'Tilli, S.' 4 'Briganti, F.' 5 'Scozzafava, A.' 6 # _citation.id primary _citation.title 'Crystal structure of the blue multicopper oxidase from the white-rot fungus Trametes trogii complexed with p-toluate' _citation.journal_abbrev Inorg.Chim.Acta. _citation.journal_volume 361 _citation.page_first 4129 _citation.page_last 4137 _citation.year 2008 _citation.journal_id_ASTM ICHAA3 _citation.country SZ _citation.journal_id_ISSN 0020-1693 _citation.journal_id_CSD 0155 _citation.book_publisher ? _citation.pdbx_database_id_PubMed ? _citation.pdbx_database_id_DOI 10.1016/j.ica.2008.03.091 # loop_ _citation_author.citation_id _citation_author.name _citation_author.ordinal primary 'Matera, I.' 1 primary 'Gullotto, A.' 2 primary 'Tilli, S.' 3 primary 'Ferraroni, M.' 4 primary 'Scozzafava, A.' 5 primary 'Briganti, F.' 6 # _cell.entry_id 2HRH _cell.length_a 84.932 _cell.length_b 84.327 _cell.length_c 108.383 _cell.angle_alpha 90.00 _cell.angle_beta 90.00 _cell.angle_gamma 90.00 _cell.Z_PDB 4 _cell.pdbx_unique_axis ? _cell.length_a_esd ? _cell.length_b_esd ? _cell.length_c_esd ? _cell.angle_alpha_esd ? _cell.angle_beta_esd ? _cell.angle_gamma_esd ? # _symmetry.entry_id 2HRH _symmetry.space_group_name_H-M 'P 21 21 21' _symmetry.pdbx_full_space_group_name_H-M ? _symmetry.cell_setting ? _symmetry.Int_Tables_number 19 _symmetry.space_group_name_Hall ? # loop_ _entity.id _entity.type _entity.src_method _entity.pdbx_description _entity.formula_weight _entity.pdbx_number_of_molecules _entity.pdbx_ec _entity.pdbx_mutation _entity.pdbx_fragment _entity.details 1 polymer nat Laccase 53143.770 1 1.10.3.2 ? ? ? 2 non-polymer man 'DI(N-ACETYL-D-GLUCOSAMINE)' 424.400 2 ? ? ? ? 3 non-polymer syn 'COPPER (II) ION' 63.546 4 ? ? ? ? 4 water nat water 18.015 255 ? ? ? ? # _entity_name_com.entity_id 1 _entity_name_com.name 'BLUE LACCASE' # _entity_poly.entity_id 1 _entity_poly.type 'polypeptide(L)' _entity_poly.nstd_linkage no _entity_poly.nstd_monomer no _entity_poly.pdbx_seq_one_letter_code ;AIGPVADLTISNGAVSPDGFSRQAILVNDVFPSPLITGNKGDRFQLNVIDNMTNHTMLKSTSIHWHGFFQHGTNWADGPA FVNQCPISTGHAFLYDFQVPDQAGTFWYHSHLSTQYCDGLRGPIVVYDPQDPHKSLYDVDDDSTVITLADWYHLAAKVGS PVPTADATLINGLGRSIDTLNADLAVITVTKGKRYRFRLVSLSCDPNHVFSIDGHSLTVIEADSVNLKPQTVDSIQIFAA QRYSFVLNADQDVGNYWIRALPNSGTRNFDGGVNSAILRYDGAAPVEPTTSQTPSTNPLVESALTTLEGTAAPGSPAPGG VDLALNMAFGFAGGKFTINGASFTPPTVPVLLQILSGAQSAQDLLPSGSVYSLPANADIEISLPATAAAPGFPHPFHLHG HTFAVVRSAGSSTYNYENPVYRDVVSTGSPGDNVTIRFRTDNPGPWFLHCHIDFHLEAGFAVVMAEDIPEVAATNPVPQA WSDLCPTYDALSPDDQ ; _entity_poly.pdbx_seq_one_letter_code_can ;AIGPVADLTISNGAVSPDGFSRQAILVNDVFPSPLITGNKGDRFQLNVIDNMTNHTMLKSTSIHWHGFFQHGTNWADGPA FVNQCPISTGHAFLYDFQVPDQAGTFWYHSHLSTQYCDGLRGPIVVYDPQDPHKSLYDVDDDSTVITLADWYHLAAKVGS PVPTADATLINGLGRSIDTLNADLAVITVTKGKRYRFRLVSLSCDPNHVFSIDGHSLTVIEADSVNLKPQTVDSIQIFAA QRYSFVLNADQDVGNYWIRALPNSGTRNFDGGVNSAILRYDGAAPVEPTTSQTPSTNPLVESALTTLEGTAAPGSPAPGG VDLALNMAFGFAGGKFTINGASFTPPTVPVLLQILSGAQSAQDLLPSGSVYSLPANADIEISLPATAAAPGFPHPFHLHG HTFAVVRSAGSSTYNYENPVYRDVVSTGSPGDNVTIRFRTDNPGPWFLHCHIDFHLEAGFAVVMAEDIPEVAATNPVPQA WSDLCPTYDALSPDDQ ; _entity_poly.pdbx_strand_id A _entity_poly.pdbx_target_identifier ? # loop_ _entity_poly_seq.entity_id _entity_poly_seq.num _entity_poly_seq.mon_id _entity_poly_seq.hetero 1 1 ALA n 1 2 ILE n 1 3 GLY n 1 4 PRO n 1 5 VAL n 1 6 ALA n 1 7 ASP n 1 8 LEU n 1 9 THR n 1 10 ILE n 1 11 SER n 1 12 ASN n 1 13 GLY n 1 14 ALA n 1 15 VAL n 1 16 SER n 1 17 PRO n 1 18 ASP n 1 19 GLY n 1 20 PHE n 1 21 SER n 1 22 ARG n 1 23 GLN n 1 24 ALA n 1 25 ILE n 1 26 LEU n 1 27 VAL n 1 28 ASN n 1 29 ASP n 1 30 VAL n 1 31 PHE n 1 32 PRO n 1 33 SER n 1 34 PRO n 1 35 LEU n 1 36 ILE n 1 37 THR n 1 38 GLY n 1 39 ASN n 1 40 LYS n 1 41 GLY n 1 42 ASP n 1 43 ARG n 1 44 PHE n 1 45 GLN n 1 46 LEU n 1 47 ASN n 1 48 VAL n 1 49 ILE n 1 50 ASP n 1 51 ASN n 1 52 MET n 1 53 THR n 1 54 ASN n 1 55 HIS n 1 56 THR n 1 57 MET n 1 58 LEU n 1 59 LYS n 1 60 SER n 1 61 THR n 1 62 SER n 1 63 ILE n 1 64 HIS n 1 65 TRP n 1 66 HIS n 1 67 GLY n 1 68 PHE n 1 69 PHE n 1 70 GLN n 1 71 HIS n 1 72 GLY n 1 73 THR n 1 74 ASN n 1 75 TRP n 1 76 ALA n 1 77 ASP n 1 78 GLY n 1 79 PRO n 1 80 ALA n 1 81 PHE n 1 82 VAL n 1 83 ASN n 1 84 GLN n 1 85 CYS n 1 86 PRO n 1 87 ILE n 1 88 SER n 1 89 THR n 1 90 GLY n 1 91 HIS n 1 92 ALA n 1 93 PHE n 1 94 LEU n 1 95 TYR n 1 96 ASP n 1 97 PHE n 1 98 GLN n 1 99 VAL n 1 100 PRO n 1 101 ASP n 1 102 GLN n 1 103 ALA n 1 104 GLY n 1 105 THR n 1 106 PHE n 1 107 TRP n 1 108 TYR n 1 109 HIS n 1 110 SER n 1 111 HIS n 1 112 LEU n 1 113 SER n 1 114 THR n 1 115 GLN n 1 116 TYR n 1 117 CYS n 1 118 ASP n 1 119 GLY n 1 120 LEU n 1 121 ARG n 1 122 GLY n 1 123 PRO n 1 124 ILE n 1 125 VAL n 1 126 VAL n 1 127 TYR n 1 128 ASP n 1 129 PRO n 1 130 GLN n 1 131 ASP n 1 132 PRO n 1 133 HIS n 1 134 LYS n 1 135 SER n 1 136 LEU n 1 137 TYR n 1 138 ASP n 1 139 VAL n 1 140 ASP n 1 141 ASP n 1 142 ASP n 1 143 SER n 1 144 THR n 1 145 VAL n 1 146 ILE n 1 147 THR n 1 148 LEU n 1 149 ALA n 1 150 ASP n 1 151 TRP n 1 152 TYR n 1 153 HIS n 1 154 LEU n 1 155 ALA n 1 156 ALA n 1 157 LYS n 1 158 VAL n 1 159 GLY n 1 160 SER n 1 161 PRO n 1 162 VAL n 1 163 PRO n 1 164 THR n 1 165 ALA n 1 166 ASP n 1 167 ALA n 1 168 THR n 1 169 LEU n 1 170 ILE n 1 171 ASN n 1 172 GLY n 1 173 LEU n 1 174 GLY n 1 175 ARG n 1 176 SER n 1 177 ILE n 1 178 ASP n 1 179 THR n 1 180 LEU n 1 181 ASN n 1 182 ALA n 1 183 ASP n 1 184 LEU n 1 185 ALA n 1 186 VAL n 1 187 ILE n 1 188 THR n 1 189 VAL n 1 190 THR n 1 191 LYS n 1 192 GLY n 1 193 LYS n 1 194 ARG n 1 195 TYR n 1 196 ARG n 1 197 PHE n 1 198 ARG n 1 199 LEU n 1 200 VAL n 1 201 SER n 1 202 LEU n 1 203 SER n 1 204 CYS n 1 205 ASP n 1 206 PRO n 1 207 ASN n 1 208 HIS n 1 209 VAL n 1 210 PHE n 1 211 SER n 1 212 ILE n 1 213 ASP n 1 214 GLY n 1 215 HIS n 1 216 SER n 1 217 LEU n 1 218 THR n 1 219 VAL n 1 220 ILE n 1 221 GLU n 1 222 ALA n 1 223 ASP n 1 224 SER n 1 225 VAL n 1 226 ASN n 1 227 LEU n 1 228 LYS n 1 229 PRO n 1 230 GLN n 1 231 THR n 1 232 VAL n 1 233 ASP n 1 234 SER n 1 235 ILE n 1 236 GLN n 1 237 ILE n 1 238 PHE n 1 239 ALA n 1 240 ALA n 1 241 GLN n 1 242 ARG n 1 243 TYR n 1 244 SER n 1 245 PHE n 1 246 VAL n 1 247 LEU n 1 248 ASN n 1 249 ALA n 1 250 ASP n 1 251 GLN n 1 252 ASP n 1 253 VAL n 1 254 GLY n 1 255 ASN n 1 256 TYR n 1 257 TRP n 1 258 ILE n 1 259 ARG n 1 260 ALA n 1 261 LEU n 1 262 PRO n 1 263 ASN n 1 264 SER n 1 265 GLY n 1 266 THR n 1 267 ARG n 1 268 ASN n 1 269 PHE n 1 270 ASP n 1 271 GLY n 1 272 GLY n 1 273 VAL n 1 274 ASN n 1 275 SER n 1 276 ALA n 1 277 ILE n 1 278 LEU n 1 279 ARG n 1 280 TYR n 1 281 ASP n 1 282 GLY n 1 283 ALA n 1 284 ALA n 1 285 PRO n 1 286 VAL n 1 287 GLU n 1 288 PRO n 1 289 THR n 1 290 THR n 1 291 SER n 1 292 GLN n 1 293 THR n 1 294 PRO n 1 295 SER n 1 296 THR n 1 297 ASN n 1 298 PRO n 1 299 LEU n 1 300 VAL n 1 301 GLU n 1 302 SER n 1 303 ALA n 1 304 LEU n 1 305 THR n 1 306 THR n 1 307 LEU n 1 308 GLU n 1 309 GLY n 1 310 THR n 1 311 ALA n 1 312 ALA n 1 313 PRO n 1 314 GLY n 1 315 SER n 1 316 PRO n 1 317 ALA n 1 318 PRO n 1 319 GLY n 1 320 GLY n 1 321 VAL n 1 322 ASP n 1 323 LEU n 1 324 ALA n 1 325 LEU n 1 326 ASN n 1 327 MET n 1 328 ALA n 1 329 PHE n 1 330 GLY n 1 331 PHE n 1 332 ALA n 1 333 GLY n 1 334 GLY n 1 335 LYS n 1 336 PHE n 1 337 THR n 1 338 ILE n 1 339 ASN n 1 340 GLY n 1 341 ALA n 1 342 SER n 1 343 PHE n 1 344 THR n 1 345 PRO n 1 346 PRO n 1 347 THR n 1 348 VAL n 1 349 PRO n 1 350 VAL n 1 351 LEU n 1 352 LEU n 1 353 GLN n 1 354 ILE n 1 355 LEU n 1 356 SER n 1 357 GLY n 1 358 ALA n 1 359 GLN n 1 360 SER n 1 361 ALA n 1 362 GLN n 1 363 ASP n 1 364 LEU n 1 365 LEU n 1 366 PRO n 1 367 SER n 1 368 GLY n 1 369 SER n 1 370 VAL n 1 371 TYR n 1 372 SER n 1 373 LEU n 1 374 PRO n 1 375 ALA n 1 376 ASN n 1 377 ALA n 1 378 ASP n 1 379 ILE n 1 380 GLU n 1 381 ILE n 1 382 SER n 1 383 LEU n 1 384 PRO n 1 385 ALA n 1 386 THR n 1 387 ALA n 1 388 ALA n 1 389 ALA n 1 390 PRO n 1 391 GLY n 1 392 PHE n 1 393 PRO n 1 394 HIS n 1 395 PRO n 1 396 PHE n 1 397 HIS n 1 398 LEU n 1 399 HIS n 1 400 GLY n 1 401 HIS n 1 402 THR n 1 403 PHE n 1 404 ALA n 1 405 VAL n 1 406 VAL n 1 407 ARG n 1 408 SER n 1 409 ALA n 1 410 GLY n 1 411 SER n 1 412 SER n 1 413 THR n 1 414 TYR n 1 415 ASN n 1 416 TYR n 1 417 GLU n 1 418 ASN n 1 419 PRO n 1 420 VAL n 1 421 TYR n 1 422 ARG n 1 423 ASP n 1 424 VAL n 1 425 VAL n 1 426 SER n 1 427 THR n 1 428 GLY n 1 429 SER n 1 430 PRO n 1 431 GLY n 1 432 ASP n 1 433 ASN n 1 434 VAL n 1 435 THR n 1 436 ILE n 1 437 ARG n 1 438 PHE n 1 439 ARG n 1 440 THR n 1 441 ASP n 1 442 ASN n 1 443 PRO n 1 444 GLY n 1 445 PRO n 1 446 TRP n 1 447 PHE n 1 448 LEU n 1 449 HIS n 1 450 CYS n 1 451 HIS n 1 452 ILE n 1 453 ASP n 1 454 PHE n 1 455 HIS n 1 456 LEU n 1 457 GLU n 1 458 ALA n 1 459 GLY n 1 460 PHE n 1 461 ALA n 1 462 VAL n 1 463 VAL n 1 464 MET n 1 465 ALA n 1 466 GLU n 1 467 ASP n 1 468 ILE n 1 469 PRO n 1 470 GLU n 1 471 VAL n 1 472 ALA n 1 473 ALA n 1 474 THR n 1 475 ASN n 1 476 PRO n 1 477 VAL n 1 478 PRO n 1 479 GLN n 1 480 ALA n 1 481 TRP n 1 482 SER n 1 483 ASP n 1 484 LEU n 1 485 CYS n 1 486 PRO n 1 487 THR n 1 488 TYR n 1 489 ASP n 1 490 ALA n 1 491 LEU n 1 492 SER n 1 493 PRO n 1 494 ASP n 1 495 ASP n 1 496 GLN n # _entity_src_nat.entity_id 1 _entity_src_nat.pdbx_src_id 1 _entity_src_nat.pdbx_alt_source_flag sample _entity_src_nat.pdbx_beg_seq_num ? _entity_src_nat.pdbx_end_seq_num ? _entity_src_nat.common_name ? _entity_src_nat.pdbx_organism_scientific 'Funalia trogii' _entity_src_nat.pdbx_ncbi_taxonomy_id 76130 _entity_src_nat.genus Funalia _entity_src_nat.species ? _entity_src_nat.strain '201 (DSM11919)' _entity_src_nat.tissue ? _entity_src_nat.tissue_fraction ? _entity_src_nat.pdbx_secretion ? _entity_src_nat.pdbx_fragment ? _entity_src_nat.pdbx_variant ? _entity_src_nat.pdbx_cell_line ? _entity_src_nat.pdbx_atcc ? _entity_src_nat.pdbx_cellular_location ? _entity_src_nat.pdbx_organ ? _entity_src_nat.pdbx_organelle ? _entity_src_nat.pdbx_cell ? _entity_src_nat.pdbx_plasmid_name ? _entity_src_nat.pdbx_plasmid_details ? _entity_src_nat.details ? # _struct_ref.id 1 _struct_ref.db_name UNP _struct_ref.db_code Q9HDQ0_9APHY _struct_ref.pdbx_db_accession Q9HDQ0 _struct_ref.entity_id 1 _struct_ref.pdbx_seq_one_letter_code ;AIGPVADLTISNGAVSPDGFSRQAILVNDVFPSPLITGNKGDRFQLNVIDNMTNHTMLKSTSIHWHGFFQHGTNWADGPA FVNQCPISTGHAFLYDFQVPDQAGTFWYHSHLSTQYCDGLRGPIVVYDPQDPHKSLYDVDDDSTVITLADWYHLAAKVGS PVPTADATLINGLGRSIDTLNADLAVITVTKGKRYRFRLVSLSCDPNHVFSIDGHSLTVIEADSVNLKPQTVDSIQIFAA QRYSFVLNADQDVGNYWIRALPNSGTRNFDGGVNSAILRYDGAAPVEPTTSQTPSTNPLVESALTTLEGTAAPGSPAPGG VDLALNMAFGFAGGKFTINGASFTPPTVPVLLQILSGAQSAQDLLPSGSVYSLPANADIEISLPATAAAPGFPHPFHLHG HTFAVVRSAGSSTYNYENPVYRDVVSTGSPGDNVTIRFRTDNPGPWFLHCHIDFHLEAGFAVVMAEDIPEVAATNPVPQA WSDLCPTYDALSPDDQ ; _struct_ref.pdbx_align_begin 22 _struct_ref.pdbx_db_isoform ? # _struct_ref_seq.align_id 1 _struct_ref_seq.ref_id 1 _struct_ref_seq.pdbx_PDB_id_code 2HRH _struct_ref_seq.pdbx_strand_id A _struct_ref_seq.seq_align_beg 1 _struct_ref_seq.pdbx_seq_align_beg_ins_code ? _struct_ref_seq.seq_align_end 496 _struct_ref_seq.pdbx_seq_align_end_ins_code ? _struct_ref_seq.pdbx_db_accession Q9HDQ0 _struct_ref_seq.db_align_beg 22 _struct_ref_seq.pdbx_db_align_beg_ins_code ? _struct_ref_seq.db_align_end 517 _struct_ref_seq.pdbx_db_align_end_ins_code ? _struct_ref_seq.pdbx_auth_seq_align_beg 1 _struct_ref_seq.pdbx_auth_seq_align_end 496 # loop_ _chem_comp.id _chem_comp.type _chem_comp.mon_nstd_flag _chem_comp.name _chem_comp.pdbx_synonyms _chem_comp.formula _chem_comp.formula_weight ALA 'L-peptide linking' y ALANINE ? 'C3 H7 N O2' 89.093 ARG 'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1' 175.209 ASN 'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3' 132.118 ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4' 133.103 CBS D-saccharide . 'DI(N-ACETYL-D-GLUCOSAMINE)' ? 'C16 H28 N2 O11' 424.400 CU non-polymer . 'COPPER (II) ION' ? 'Cu 2' 63.546 CYS 'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S' 121.158 GLN 'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3' 146.144 GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4' 147.129 GLY 'peptide linking' y GLYCINE ? 'C2 H5 N O2' 75.067 HIS 'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1' 156.162 HOH non-polymer . WATER ? 'H2 O' 18.015 ILE 'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2' 131.173 LEU 'L-peptide linking' y LEUCINE ? 'C6 H13 N O2' 131.173 LYS 'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1' 147.195 MET 'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S' 149.211 PHE 'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2' 165.189 PRO 'L-peptide linking' y PROLINE ? 'C5 H9 N O2' 115.130 SER 'L-peptide linking' y SERINE ? 'C3 H7 N O3' 105.093 THR 'L-peptide linking' y THREONINE ? 'C4 H9 N O3' 119.119 TRP 'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2' 204.225 TYR 'L-peptide linking' y TYROSINE ? 'C9 H11 N O3' 181.189 VAL 'L-peptide linking' y VALINE ? 'C5 H11 N O2' 117.146 # _exptl.entry_id 2HRH _exptl.method 'X-RAY DIFFRACTION' _exptl.crystals_number 1 # _exptl_crystal.id 1 _exptl_crystal.density_meas ? _exptl_crystal.density_Matthews 3.65 _exptl_crystal.density_percent_sol 66.29 _exptl_crystal.description ? _exptl_crystal.F_000 ? _exptl_crystal.preparation ? # _exptl_crystal_grow.crystal_id 1 _exptl_crystal_grow.method 'VAPOR DIFFUSION, SITTING DROP' _exptl_crystal_grow.temp 296 _exptl_crystal_grow.temp_details ? _exptl_crystal_grow.pH 7.5 _exptl_crystal_grow.pdbx_details 'PEG 8000, calcium acetato, PEG 400, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 296K' _exptl_crystal_grow.pdbx_pH_range . # _diffrn.id 1 _diffrn.ambient_temp 100 _diffrn.ambient_temp_details ? _diffrn.crystal_id 1 # _diffrn_detector.diffrn_id 1 _diffrn_detector.detector CCD _diffrn_detector.type 'OXFORD ONYX CCD' _diffrn_detector.pdbx_collection_date 2005-10-13 _diffrn_detector.details ? # _diffrn_radiation.diffrn_id 1 _diffrn_radiation.wavelength_id 1 _diffrn_radiation.pdbx_monochromatic_or_laue_m_l M _diffrn_radiation.monochromator graphite _diffrn_radiation.pdbx_diffrn_protocol 'SINGLE WAVELENGTH' _diffrn_radiation.pdbx_scattering_type x-ray # _diffrn_radiation_wavelength.id 1 _diffrn_radiation_wavelength.wavelength 1.5418 _diffrn_radiation_wavelength.wt 1.0 # _diffrn_source.diffrn_id 1 _diffrn_source.source 'SEALED TUBE' _diffrn_source.type 'OXFORD DIFFRACTION ENHANCED ULTRA' _diffrn_source.pdbx_synchrotron_site ? _diffrn_source.pdbx_synchrotron_beamline ? _diffrn_source.pdbx_wavelength 1.5418 _diffrn_source.pdbx_wavelength_list ? # _reflns.entry_id 2HRH _reflns.observed_criterion_sigma_F ? _reflns.observed_criterion_sigma_I ? _reflns.d_resolution_high 2.60 _reflns.d_resolution_low 45.69 _reflns.number_all 22722 _reflns.number_obs 21268 _reflns.percent_possible_obs 92.4 _reflns.pdbx_Rmerge_I_obs 0.133 _reflns.pdbx_Rsym_value ? _reflns.pdbx_netI_over_sigmaI 8.0 _reflns.B_iso_Wilson_estimate ? _reflns.pdbx_redundancy 2.8 _reflns.R_free_details ? _reflns.limit_h_max ? _reflns.limit_h_min ? _reflns.limit_k_max ? _reflns.limit_k_min ? _reflns.limit_l_max ? _reflns.limit_l_min ? _reflns.observed_criterion_F_max ? _reflns.observed_criterion_F_min ? _reflns.pdbx_chi_squared ? _reflns.pdbx_scaling_rejects ? _reflns.pdbx_ordinal 1 _reflns.pdbx_diffrn_id 1 # _reflns_shell.d_res_high 2.60 _reflns_shell.d_res_low 2.74 _reflns_shell.percent_possible_all 95.5 _reflns_shell.Rmerge_I_obs 0.345 _reflns_shell.pdbx_Rsym_value ? _reflns_shell.meanI_over_sigI_obs 3.3 _reflns_shell.pdbx_redundancy 2.8 _reflns_shell.percent_possible_obs ? _reflns_shell.number_unique_all 3352 _reflns_shell.number_measured_all ? _reflns_shell.number_measured_obs ? _reflns_shell.number_unique_obs ? _reflns_shell.pdbx_chi_squared ? _reflns_shell.pdbx_ordinal 1 _reflns_shell.pdbx_diffrn_id 1 # _refine.entry_id 2HRH _refine.ls_number_reflns_obs 20201 _refine.ls_number_reflns_all 22722 _refine.pdbx_ls_sigma_I ? _refine.pdbx_ls_sigma_F ? _refine.pdbx_data_cutoff_high_absF ? _refine.pdbx_data_cutoff_low_absF ? _refine.pdbx_data_cutoff_high_rms_absF ? _refine.ls_d_res_low 39.53 _refine.ls_d_res_high 2.60 _refine.ls_percent_reflns_obs 90.99 _refine.ls_R_factor_obs 0.17798 _refine.ls_R_factor_all 0.216 _refine.ls_R_factor_R_work 0.1749 _refine.ls_R_factor_R_free 0.23337 _refine.ls_R_factor_R_free_error ? _refine.ls_R_factor_R_free_error_details ? _refine.ls_percent_reflns_R_free 5.1 _refine.ls_number_reflns_R_free 1141 _refine.ls_number_parameters ? _refine.ls_number_restraints ? _refine.occupancy_min ? _refine.occupancy_max ? _refine.correlation_coeff_Fo_to_Fc 0.930 _refine.correlation_coeff_Fo_to_Fc_free 0.879 _refine.B_iso_mean 32.973 _refine.aniso_B[1][1] -0.11 _refine.aniso_B[2][2] -0.22 _refine.aniso_B[3][3] 0.34 _refine.aniso_B[1][2] 0.00 _refine.aniso_B[1][3] 0.00 _refine.aniso_B[2][3] 0.00 _refine.solvent_model_details 'BABINET MODEL WITH MASK' _refine.solvent_model_param_ksol ? _refine.solvent_model_param_bsol ? _refine.pdbx_solvent_vdw_probe_radii 1.40 _refine.pdbx_solvent_ion_probe_radii 0.80 _refine.pdbx_solvent_shrinkage_radii 0.80 _refine.pdbx_ls_cross_valid_method THROUGHOUT _refine.details ? _refine.pdbx_starting_model 'Blue Laccase from Panus tigrinus (not yet deposited)' _refine.pdbx_method_to_determine_struct 'MOLECULAR REPLACEMENT' _refine.pdbx_isotropic_thermal_model ? _refine.pdbx_stereochemistry_target_values 'MAXIMUM LIKELIHOOD' _refine.pdbx_stereochem_target_val_spec_case ? _refine.pdbx_R_Free_selection_details RANDOM _refine.pdbx_overall_ESU_R 0.431 _refine.pdbx_overall_ESU_R_Free 0.279 _refine.overall_SU_ML 0.174 _refine.overall_SU_B 7.960 _refine.ls_redundancy_reflns_obs ? _refine.B_iso_min ? _refine.B_iso_max ? _refine.overall_SU_R_Cruickshank_DPI ? _refine.overall_SU_R_free ? _refine.ls_wR_factor_R_free ? _refine.ls_wR_factor_R_work ? _refine.overall_FOM_free_R_set ? _refine.overall_FOM_work_R_set ? _refine.pdbx_refine_id 'X-RAY DIFFRACTION' _refine.pdbx_overall_phase_error ? _refine.pdbx_diffrn_id 1 _refine.pdbx_TLS_residual_ADP_flag ? _refine.pdbx_overall_SU_R_free_Cruickshank_DPI ? _refine.pdbx_overall_SU_R_Blow_DPI ? _refine.pdbx_overall_SU_R_free_Blow_DPI ? # _refine_hist.pdbx_refine_id 'X-RAY DIFFRACTION' _refine_hist.cycle_id LAST _refine_hist.pdbx_number_atoms_protein 3755 _refine_hist.pdbx_number_atoms_nucleic_acid 0 _refine_hist.pdbx_number_atoms_ligand 60 _refine_hist.number_atoms_solvent 255 _refine_hist.number_atoms_total 4070 _refine_hist.d_res_high 2.60 _refine_hist.d_res_low 39.53 # loop_ _refine_ls_restr.type _refine_ls_restr.dev_ideal _refine_ls_restr.dev_ideal_target _refine_ls_restr.weight _refine_ls_restr.number _refine_ls_restr.pdbx_refine_id _refine_ls_restr.pdbx_restraint_function r_bond_refined_d 0.016 0.022 ? 3924 'X-RAY DIFFRACTION' ? r_angle_refined_deg 1.905 1.955 ? 5392 'X-RAY DIFFRACTION' ? r_dihedral_angle_1_deg 7.695 5.000 ? 495 'X-RAY DIFFRACTION' ? r_dihedral_angle_2_deg 38.052 24.444 ? 171 'X-RAY DIFFRACTION' ? r_dihedral_angle_3_deg 16.556 15.000 ? 521 'X-RAY DIFFRACTION' ? r_dihedral_angle_4_deg 20.129 15.000 ? 15 'X-RAY DIFFRACTION' ? r_chiral_restr 0.159 0.200 ? 618 'X-RAY DIFFRACTION' ? r_gen_planes_refined 0.008 0.020 ? 3076 'X-RAY DIFFRACTION' ? r_nbd_refined 0.251 0.200 ? 1974 'X-RAY DIFFRACTION' ? r_nbtor_refined 0.323 0.200 ? 2640 'X-RAY DIFFRACTION' ? r_xyhbond_nbd_refined 0.176 0.200 ? 327 'X-RAY DIFFRACTION' ? r_metal_ion_refined 0.236 0.200 ? 1 'X-RAY DIFFRACTION' ? r_symmetry_vdw_refined 0.249 0.200 ? 35 'X-RAY DIFFRACTION' ? r_symmetry_hbond_refined 0.283 0.200 ? 12 'X-RAY DIFFRACTION' ? r_mcbond_it 0.699 1.500 ? 2524 'X-RAY DIFFRACTION' ? r_mcangle_it 1.236 2.000 ? 4020 'X-RAY DIFFRACTION' ? r_scbond_it 1.837 3.000 ? 1570 'X-RAY DIFFRACTION' ? r_scangle_it 2.807 4.500 ? 1372 'X-RAY DIFFRACTION' ? # _refine_ls_shell.pdbx_total_number_of_bins_used 20 _refine_ls_shell.d_res_high 2.600 _refine_ls_shell.d_res_low 2.668 _refine_ls_shell.number_reflns_R_work 1611 _refine_ls_shell.R_factor_R_work 0.208 _refine_ls_shell.percent_reflns_obs 94.94 _refine_ls_shell.R_factor_R_free 0.327 _refine_ls_shell.R_factor_R_free_error ? _refine_ls_shell.percent_reflns_R_free ? _refine_ls_shell.number_reflns_R_free 77 _refine_ls_shell.number_reflns_all ? _refine_ls_shell.R_factor_all ? _refine_ls_shell.number_reflns_obs ? _refine_ls_shell.redundancy_reflns_obs ? _refine_ls_shell.pdbx_refine_id 'X-RAY DIFFRACTION' # _struct.entry_id 2HRH _struct.title 'Crystal Structure of Blue Laccase from Trametes trogii' _struct.pdbx_descriptor 'Laccase (E.C.1.10.3.2)' _struct.pdbx_model_details ? _struct.pdbx_CASP_flag ? _struct.pdbx_model_type_details ? # _struct_keywords.entry_id 2HRH _struct_keywords.pdbx_keywords OXIDOREDUCTASE _struct_keywords.text 'laccase, oxidoreductase, lignin degradation' # loop_ _struct_asym.id _struct_asym.pdbx_blank_PDB_chainid_flag _struct_asym.pdbx_modified _struct_asym.entity_id _struct_asym.details A N N 1 ? B N N 2 ? C N N 2 ? D N N 3 ? E N N 3 ? F N N 3 ? G N N 3 ? H N N 4 ? # _struct_biol.id 1 # loop_ _struct_conf.conf_type_id _struct_conf.id _struct_conf.pdbx_PDB_helix_id _struct_conf.beg_label_comp_id _struct_conf.beg_label_asym_id _struct_conf.beg_label_seq_id _struct_conf.pdbx_beg_PDB_ins_code _struct_conf.end_label_comp_id _struct_conf.end_label_asym_id _struct_conf.end_label_seq_id _struct_conf.pdbx_end_PDB_ins_code _struct_conf.beg_auth_comp_id _struct_conf.beg_auth_asym_id _struct_conf.beg_auth_seq_id _struct_conf.end_auth_comp_id _struct_conf.end_auth_asym_id _struct_conf.end_auth_seq_id _struct_conf.pdbx_PDB_helix_class _struct_conf.details _struct_conf.pdbx_PDB_helix_length HELX_P HELX_P1 1 ASN A 54 ? LEU A 58 ? ASN A 54 LEU A 58 5 ? 5 HELX_P HELX_P2 2 THR A 73 ? ASP A 77 ? THR A 73 ASP A 77 5 ? 5 HELX_P HELX_P3 3 THR A 114 ? GLY A 119 ? THR A 114 GLY A 119 5 ? 6 HELX_P HELX_P4 4 HIS A 133 ? TYR A 137 ? HIS A 133 TYR A 137 5 ? 5 HELX_P HELX_P5 5 ASP A 141 ? SER A 143 ? ASP A 141 SER A 143 5 ? 3 HELX_P HELX_P6 6 PHE A 269 ? VAL A 273 ? PHE A 269 VAL A 273 5 ? 5 HELX_P HELX_P7 7 VAL A 300 ? LEU A 304 ? VAL A 300 LEU A 304 5 ? 5 HELX_P HELX_P8 8 PRO A 349 ? SER A 356 ? PRO A 349 SER A 356 1 ? 8 HELX_P HELX_P9 9 ILE A 452 ? ALA A 458 ? ILE A 452 ALA A 458 1 ? 7 HELX_P HELX_P10 10 GLU A 470 ? ASN A 475 ? GLU A 470 ASN A 475 1 ? 6 HELX_P HELX_P11 11 PRO A 478 ? ALA A 490 ? PRO A 478 ALA A 490 1 ? 13 # _struct_conf_type.id HELX_P _struct_conf_type.criteria ? _struct_conf_type.reference ? # loop_ _struct_conn.id _struct_conn.conn_type_id _struct_conn.pdbx_leaving_atom_flag _struct_conn.pdbx_PDB_id _struct_conn.ptnr1_label_asym_id _struct_conn.ptnr1_label_comp_id _struct_conn.ptnr1_label_seq_id _struct_conn.ptnr1_label_atom_id _struct_conn.pdbx_ptnr1_label_alt_id _struct_conn.pdbx_ptnr1_PDB_ins_code _struct_conn.pdbx_ptnr1_standard_comp_id _struct_conn.ptnr1_symmetry _struct_conn.ptnr2_label_asym_id _struct_conn.ptnr2_label_comp_id _struct_conn.ptnr2_label_seq_id _struct_conn.ptnr2_label_atom_id _struct_conn.pdbx_ptnr2_label_alt_id _struct_conn.pdbx_ptnr2_PDB_ins_code _struct_conn.ptnr1_auth_asym_id _struct_conn.ptnr1_auth_comp_id _struct_conn.ptnr1_auth_seq_id _struct_conn.ptnr2_auth_asym_id _struct_conn.ptnr2_auth_comp_id _struct_conn.ptnr2_auth_seq_id _struct_conn.ptnr2_symmetry _struct_conn.pdbx_ptnr3_label_atom_id _struct_conn.pdbx_ptnr3_label_seq_id _struct_conn.pdbx_ptnr3_label_comp_id _struct_conn.pdbx_ptnr3_label_asym_id _struct_conn.pdbx_ptnr3_label_alt_id _struct_conn.pdbx_ptnr3_PDB_ins_code _struct_conn.details _struct_conn.pdbx_dist_value _struct_conn.pdbx_value_order disulf1 disulf ? ? A CYS 85 SG ? ? ? 1_555 A CYS 485 SG ? ? A CYS 85 A CYS 485 1_555 ? ? ? ? ? ? ? 2.043 ? disulf2 disulf ? ? A CYS 117 SG ? ? ? 1_555 A CYS 204 SG ? ? A CYS 117 A CYS 204 1_555 ? ? ? ? ? ? ? 2.040 ? covale1 covale ? ? B CBS . C1B ? ? ? 1_555 A ASN 54 ND2 ? ? A CBS 1001 A ASN 54 1_555 ? ? ? ? ? ? ? 2.153 ? covale2 covale ? ? C CBS . C1B ? ? ? 1_555 A ASN 433 OD1 ? ? A CBS 1006 A ASN 433 1_555 ? ? ? ? ? ? ? 1.673 ? metalc1 metalc ? ? A HIS 64 NE2 ? ? ? 1_555 E CU . CU ? ? A HIS 64 A CU 498 1_555 ? ? ? ? ? ? ? 2.056 ? metalc2 metalc ? ? A HIS 66 ND1 ? ? ? 1_555 G CU . CU ? ? A HIS 66 A CU 500 1_555 ? ? ? ? ? ? ? 2.115 ? metalc3 metalc ? ? A HIS 109 NE2 ? ? ? 1_555 G CU . CU ? ? A HIS 109 A CU 500 1_555 ? ? ? ? ? ? ? 2.347 ? metalc4 metalc ? ? A HIS 394 ND1 ? ? ? 1_555 D CU . CU ? ? A HIS 394 A CU 497 1_555 ? ? ? ? ? ? ? 2.089 ? metalc5 metalc ? ? A HIS 397 NE2 ? ? ? 1_555 E CU . CU ? ? A HIS 397 A CU 498 1_555 ? ? ? ? ? ? ? 1.794 ? metalc6 metalc ? ? A HIS 399 NE2 ? ? ? 1_555 F CU . CU ? ? A HIS 399 A CU 499 1_555 ? ? ? ? ? ? ? 2.135 ? metalc7 metalc ? ? A HIS 449 NE2 ? ? ? 1_555 F CU . CU ? ? A HIS 449 A CU 499 1_555 ? ? ? ? ? ? ? 2.196 ? metalc8 metalc ? ? A HIS 451 NE2 ? ? ? 1_555 G CU . CU ? ? A HIS 451 A CU 500 1_555 ? ? ? ? ? ? ? 2.365 ? metalc9 metalc ? ? A HIS 455 ND1 ? ? ? 1_555 D CU . CU ? ? A HIS 455 A CU 497 1_555 ? ? ? ? ? ? ? 2.086 ? # loop_ _struct_conn_type.id _struct_conn_type.criteria _struct_conn_type.reference disulf ? ? covale ? ? metalc ? ? # loop_ _struct_mon_prot_cis.pdbx_id _struct_mon_prot_cis.label_comp_id _struct_mon_prot_cis.label_seq_id _struct_mon_prot_cis.label_asym_id _struct_mon_prot_cis.label_alt_id _struct_mon_prot_cis.pdbx_PDB_ins_code _struct_mon_prot_cis.auth_comp_id _struct_mon_prot_cis.auth_seq_id _struct_mon_prot_cis.auth_asym_id _struct_mon_prot_cis.pdbx_label_comp_id_2 _struct_mon_prot_cis.pdbx_label_seq_id_2 _struct_mon_prot_cis.pdbx_label_asym_id_2 _struct_mon_prot_cis.pdbx_PDB_ins_code_2 _struct_mon_prot_cis.pdbx_auth_comp_id_2 _struct_mon_prot_cis.pdbx_auth_seq_id_2 _struct_mon_prot_cis.pdbx_auth_asym_id_2 _struct_mon_prot_cis.pdbx_PDB_model_num _struct_mon_prot_cis.pdbx_omega_angle 1 GLY 3 A . ? GLY 3 A PRO 4 A ? PRO 4 A 1 6.13 2 PHE 31 A . ? PHE 31 A PRO 32 A ? PRO 32 A 1 -5.46 3 LEU 365 A . ? LEU 365 A PRO 366 A ? PRO 366 A 1 3.68 4 PHE 392 A . ? PHE 392 A PRO 393 A ? PRO 393 A 1 -5.40 # loop_ _struct_sheet.id _struct_sheet.type _struct_sheet.number_strands _struct_sheet.details A ? 4 ? B ? 4 ? C ? 6 ? D ? 5 ? E ? 5 ? F ? 2 ? G ? 5 ? # loop_ _struct_sheet_order.sheet_id _struct_sheet_order.range_id_1 _struct_sheet_order.range_id_2 _struct_sheet_order.offset _struct_sheet_order.sense A 1 2 ? anti-parallel A 2 3 ? parallel A 3 4 ? anti-parallel B 1 2 ? parallel B 2 3 ? anti-parallel B 3 4 ? anti-parallel C 1 2 ? anti-parallel C 2 3 ? parallel C 3 4 ? anti-parallel C 4 5 ? anti-parallel C 5 6 ? anti-parallel D 1 2 ? parallel D 2 3 ? anti-parallel D 3 4 ? anti-parallel D 4 5 ? anti-parallel E 1 2 ? parallel E 2 3 ? anti-parallel E 3 4 ? anti-parallel E 4 5 ? anti-parallel F 1 2 ? anti-parallel G 1 2 ? parallel G 2 3 ? anti-parallel G 3 4 ? anti-parallel G 4 5 ? anti-parallel # loop_ _struct_sheet_range.sheet_id _struct_sheet_range.id _struct_sheet_range.beg_label_comp_id _struct_sheet_range.beg_label_asym_id _struct_sheet_range.beg_label_seq_id _struct_sheet_range.pdbx_beg_PDB_ins_code _struct_sheet_range.end_label_comp_id _struct_sheet_range.end_label_asym_id _struct_sheet_range.end_label_seq_id _struct_sheet_range.pdbx_end_PDB_ins_code _struct_sheet_range.beg_auth_comp_id _struct_sheet_range.beg_auth_asym_id _struct_sheet_range.beg_auth_seq_id _struct_sheet_range.end_auth_comp_id _struct_sheet_range.end_auth_asym_id _struct_sheet_range.end_auth_seq_id A 1 ARG A 22 ? VAL A 27 ? ARG A 22 VAL A 27 A 2 VAL A 5 ? VAL A 15 ? VAL A 5 VAL A 15 A 3 ARG A 43 ? ASP A 50 ? ARG A 43 ASP A 50 A 4 ALA A 92 ? GLN A 98 ? ALA A 92 GLN A 98 B 1 ILE A 36 ? ASN A 39 ? ILE A 36 ASN A 39 B 2 ARG A 121 ? TYR A 127 ? ARG A 121 TYR A 127 B 3 GLY A 104 ? SER A 110 ? GLY A 104 SER A 110 B 4 ILE A 63 ? HIS A 66 ? ILE A 63 HIS A 66 C 1 ALA A 167 ? ILE A 170 ? ALA A 167 ILE A 170 C 2 VAL A 145 ? TRP A 151 ? VAL A 145 TRP A 151 C 3 ARG A 194 ? SER A 201 ? ARG A 194 SER A 201 C 4 ARG A 242 ? ASN A 248 ? ARG A 242 ASN A 248 C 5 LEU A 217 ? ALA A 222 ? LEU A 217 ALA A 222 C 6 VAL A 225 ? VAL A 232 ? VAL A 225 VAL A 232 D 1 VAL A 186 ? VAL A 189 ? VAL A 186 VAL A 189 D 2 SER A 275 ? TYR A 280 ? SER A 275 TYR A 280 D 3 ASN A 255 ? PRO A 262 ? ASN A 255 PRO A 262 D 4 HIS A 208 ? ILE A 212 ? HIS A 208 ILE A 212 D 5 ILE A 235 ? ILE A 237 ? ILE A 235 ILE A 237 E 1 LEU A 323 ? ASN A 326 ? LEU A 323 ASN A 326 E 2 ASP A 378 ? PRO A 384 ? ASP A 378 PRO A 384 E 3 ASN A 433 ? ARG A 439 ? ASN A 433 ARG A 439 E 4 PHE A 403 ? ARG A 407 ? PHE A 403 ARG A 407 E 5 TYR A 421 ? ARG A 422 ? TYR A 421 ARG A 422 F 1 PHE A 329 ? PHE A 331 ? PHE A 329 PHE A 331 F 2 PHE A 336 ? ILE A 338 ? PHE A 336 ILE A 338 G 1 VAL A 370 ? LEU A 373 ? VAL A 370 LEU A 373 G 2 ALA A 461 ? GLU A 466 ? ALA A 461 GLU A 466 G 3 GLY A 444 ? CYS A 450 ? GLY A 444 CYS A 450 G 4 PRO A 395 ? LEU A 398 ? PRO A 395 LEU A 398 G 5 VAL A 424 ? SER A 426 ? VAL A 424 SER A 426 # loop_ _pdbx_struct_sheet_hbond.sheet_id _pdbx_struct_sheet_hbond.range_id_1 _pdbx_struct_sheet_hbond.range_id_2 _pdbx_struct_sheet_hbond.range_1_label_atom_id _pdbx_struct_sheet_hbond.range_1_label_comp_id _pdbx_struct_sheet_hbond.range_1_label_asym_id _pdbx_struct_sheet_hbond.range_1_label_seq_id _pdbx_struct_sheet_hbond.range_1_PDB_ins_code _pdbx_struct_sheet_hbond.range_1_auth_atom_id _pdbx_struct_sheet_hbond.range_1_auth_comp_id _pdbx_struct_sheet_hbond.range_1_auth_asym_id _pdbx_struct_sheet_hbond.range_1_auth_seq_id _pdbx_struct_sheet_hbond.range_2_label_atom_id _pdbx_struct_sheet_hbond.range_2_label_comp_id _pdbx_struct_sheet_hbond.range_2_label_asym_id _pdbx_struct_sheet_hbond.range_2_label_seq_id _pdbx_struct_sheet_hbond.range_2_PDB_ins_code _pdbx_struct_sheet_hbond.range_2_auth_atom_id _pdbx_struct_sheet_hbond.range_2_auth_comp_id _pdbx_struct_sheet_hbond.range_2_auth_asym_id _pdbx_struct_sheet_hbond.range_2_auth_seq_id A 1 2 O ALA A 24 ? O ALA A 24 N GLY A 13 ? N GLY A 13 A 2 3 N LEU A 8 ? N LEU A 8 O ASN A 47 ? O ASN A 47 A 3 4 N PHE A 44 ? N PHE A 44 O PHE A 97 ? O PHE A 97 B 1 2 N GLY A 38 ? N GLY A 38 O TYR A 127 ? O TYR A 127 B 2 3 O GLY A 122 ? O GLY A 122 N TYR A 108 ? N TYR A 108 B 3 4 O HIS A 109 ? O HIS A 109 N HIS A 64 ? N HIS A 64 C 1 2 O LEU A 169 ? O LEU A 169 N ALA A 149 ? N ALA A 149 C 2 3 N ILE A 146 ? N ILE A 146 O ARG A 198 ? O ARG A 198 C 3 4 N LEU A 199 ? N LEU A 199 O TYR A 243 ? O TYR A 243 C 4 5 O VAL A 246 ? O VAL A 246 N THR A 218 ? N THR A 218 C 5 6 N ILE A 220 ? N ILE A 220 O LEU A 227 ? O LEU A 227 D 1 2 N ILE A 187 ? N ILE A 187 O ILE A 277 ? O ILE A 277 D 2 3 O ALA A 276 ? O ALA A 276 N ILE A 258 ? N ILE A 258 D 3 4 O ARG A 259 ? O ARG A 259 N SER A 211 ? N SER A 211 D 4 5 N PHE A 210 ? N PHE A 210 O ILE A 235 ? O ILE A 235 E 1 2 N LEU A 325 ? N LEU A 325 O GLU A 380 ? O GLU A 380 E 2 3 N ILE A 381 ? N ILE A 381 O ILE A 436 ? O ILE A 436 E 3 4 O ARG A 437 ? O ARG A 437 N ALA A 404 ? N ALA A 404 E 4 5 N PHE A 403 ? N PHE A 403 O ARG A 422 ? O ARG A 422 F 1 2 N GLY A 330 ? N GLY A 330 O THR A 337 ? O THR A 337 G 1 2 N TYR A 371 ? N TYR A 371 O VAL A 463 ? O VAL A 463 G 2 3 O MET A 464 ? O MET A 464 N TRP A 446 ? N TRP A 446 G 3 4 O HIS A 449 ? O HIS A 449 N HIS A 397 ? N HIS A 397 G 4 5 N PHE A 396 ? N PHE A 396 O VAL A 425 ? O VAL A 425 # loop_ _struct_site.id _struct_site.pdbx_evidence_code _struct_site.pdbx_auth_asym_id _struct_site.pdbx_auth_comp_id _struct_site.pdbx_auth_seq_id _struct_site.pdbx_auth_ins_code _struct_site.pdbx_num_residues _struct_site.details AC1 Software ? ? ? ? 15 'BINDING SITE FOR RESIDUE CBS A 1001' AC2 Software ? ? ? ? 8 'BINDING SITE FOR RESIDUE CBS A 1006' AC3 Software ? ? ? ? 4 'BINDING SITE FOR RESIDUE CU A 497' AC4 Software ? ? ? ? 6 'BINDING SITE FOR RESIDUE CU A 498' AC5 Software ? ? ? ? 6 'BINDING SITE FOR RESIDUE CU A 499' AC6 Software ? ? ? ? 7 'BINDING SITE FOR RESIDUE CU A 500' # loop_ _struct_site_gen.id _struct_site_gen.site_id _struct_site_gen.pdbx_num_res _struct_site_gen.label_comp_id _struct_site_gen.label_asym_id _struct_site_gen.label_seq_id _struct_site_gen.pdbx_auth_ins_code _struct_site_gen.auth_comp_id _struct_site_gen.auth_asym_id _struct_site_gen.auth_seq_id _struct_site_gen.label_atom_id _struct_site_gen.label_alt_id _struct_site_gen.symmetry _struct_site_gen.details 1 AC1 15 ARG A 22 ? ARG A 22 . ? 1_555 ? 2 AC1 15 GLN A 23 ? GLN A 23 . ? 1_555 ? 3 AC1 15 ASN A 54 ? ASN A 54 . ? 1_555 ? 4 AC1 15 MET A 57 ? MET A 57 . ? 1_555 ? 5 AC1 15 HIS A 153 ? HIS A 153 . ? 1_555 ? 6 AC1 15 LEU A 154 ? LEU A 154 . ? 1_555 ? 7 AC1 15 ALA A 155 ? ALA A 155 . ? 1_555 ? 8 AC1 15 VAL A 158 ? VAL A 158 . ? 1_555 ? 9 AC1 15 ARG A 194 ? ARG A 194 . ? 4_445 ? 10 AC1 15 ASN A 248 ? ASN A 248 . ? 4_445 ? 11 AC1 15 HOH H . ? HOH A 1026 . ? 1_555 ? 12 AC1 15 HOH H . ? HOH A 1061 . ? 1_555 ? 13 AC1 15 HOH H . ? HOH A 1129 . ? 1_555 ? 14 AC1 15 HOH H . ? HOH A 1131 . ? 1_555 ? 15 AC1 15 HOH H . ? HOH A 1232 . ? 1_555 ? 16 AC2 8 ALA A 324 ? ALA A 324 . ? 1_555 ? 17 AC2 8 ASN A 326 ? ASN A 326 . ? 1_555 ? 18 AC2 8 SER A 382 ? SER A 382 . ? 1_555 ? 19 AC2 8 ASN A 433 ? ASN A 433 . ? 1_555 ? 20 AC2 8 HOH H . ? HOH A 1032 . ? 1_555 ? 21 AC2 8 HOH H . ? HOH A 1197 . ? 1_555 ? 22 AC2 8 HOH H . ? HOH A 1201 . ? 1_555 ? 23 AC2 8 HOH H . ? HOH A 1238 . ? 1_555 ? 24 AC3 4 HIS A 394 ? HIS A 394 . ? 1_555 ? 25 AC3 4 CYS A 450 ? CYS A 450 . ? 1_555 ? 26 AC3 4 ILE A 452 ? ILE A 452 . ? 1_555 ? 27 AC3 4 HIS A 455 ? HIS A 455 . ? 1_555 ? 28 AC4 6 HIS A 64 ? HIS A 64 . ? 1_555 ? 29 AC4 6 HIS A 66 ? HIS A 66 . ? 1_555 ? 30 AC4 6 HIS A 397 ? HIS A 397 . ? 1_555 ? 31 AC4 6 HIS A 399 ? HIS A 399 . ? 1_555 ? 32 AC4 6 CU F . ? CU A 499 . ? 1_555 ? 33 AC4 6 CU G . ? CU A 500 . ? 1_555 ? 34 AC5 6 HIS A 111 ? HIS A 111 . ? 1_555 ? 35 AC5 6 HIS A 397 ? HIS A 397 . ? 1_555 ? 36 AC5 6 HIS A 399 ? HIS A 399 . ? 1_555 ? 37 AC5 6 HIS A 449 ? HIS A 449 . ? 1_555 ? 38 AC5 6 CU E . ? CU A 498 . ? 1_555 ? 39 AC5 6 CU G . ? CU A 500 . ? 1_555 ? 40 AC6 7 HIS A 64 ? HIS A 64 . ? 1_555 ? 41 AC6 7 HIS A 66 ? HIS A 66 . ? 1_555 ? 42 AC6 7 HIS A 109 ? HIS A 109 . ? 1_555 ? 43 AC6 7 HIS A 397 ? HIS A 397 . ? 1_555 ? 44 AC6 7 HIS A 451 ? HIS A 451 . ? 1_555 ? 45 AC6 7 CU E . ? CU A 498 . ? 1_555 ? 46 AC6 7 CU F . ? CU A 499 . ? 1_555 ? # _database_PDB_matrix.entry_id 2HRH _database_PDB_matrix.origx[1][1] 1.000000 _database_PDB_matrix.origx[1][2] 0.000000 _database_PDB_matrix.origx[1][3] 0.000000 _database_PDB_matrix.origx[2][1] 0.000000 _database_PDB_matrix.origx[2][2] 1.000000 _database_PDB_matrix.origx[2][3] 0.000000 _database_PDB_matrix.origx[3][1] 0.000000 _database_PDB_matrix.origx[3][2] 0.000000 _database_PDB_matrix.origx[3][3] 1.000000 _database_PDB_matrix.origx_vector[1] 0.00000 _database_PDB_matrix.origx_vector[2] 0.00000 _database_PDB_matrix.origx_vector[3] 0.00000 # _atom_sites.entry_id 2HRH _atom_sites.fract_transf_matrix[1][1] 0.011774 _atom_sites.fract_transf_matrix[1][2] 0.000000 _atom_sites.fract_transf_matrix[1][3] 0.000000 _atom_sites.fract_transf_matrix[2][1] 0.000000 _atom_sites.fract_transf_matrix[2][2] 0.011859 _atom_sites.fract_transf_matrix[2][3] 0.000000 _atom_sites.fract_transf_matrix[3][1] 0.000000 _atom_sites.fract_transf_matrix[3][2] 0.000000 _atom_sites.fract_transf_matrix[3][3] 0.009227 _atom_sites.fract_transf_vector[1] 0.00000 _atom_sites.fract_transf_vector[2] 0.00000 _atom_sites.fract_transf_vector[3] 0.00000 # loop_ _atom_type.symbol C CU H N O S # loop_ _atom_site.group_PDB _atom_site.id _atom_site.type_symbol _atom_site.label_atom_id _atom_site.label_alt_id _atom_site.label_comp_id _atom_site.label_asym_id _atom_site.label_entity_id _atom_site.label_seq_id _atom_site.pdbx_PDB_ins_code _atom_site.Cartn_x _atom_site.Cartn_y _atom_site.Cartn_z _atom_site.occupancy _atom_site.B_iso_or_equiv _atom_site.pdbx_formal_charge _atom_site.auth_seq_id _atom_site.auth_comp_id _atom_site.auth_asym_id _atom_site.auth_atom_id _atom_site.pdbx_PDB_model_num ATOM 1 N N . ALA A 1 1 ? -6.084 -33.462 5.427 1.00 34.19 ? 1 ALA A N 1 ATOM 2 C CA . ALA A 1 1 ? -5.988 -33.653 3.958 1.00 33.14 ? 1 ALA A CA 1 ATOM 3 C C . ALA A 1 1 ? -6.309 -35.077 3.549 1.00 33.41 ? 1 ALA A C 1 ATOM 4 O O . ALA A 1 1 ? -6.562 -35.954 4.354 1.00 33.86 ? 1 ALA A O 1 ATOM 5 C CB . ALA A 1 1 ? -4.648 -33.272 3.465 1.00 32.53 ? 1 ALA A CB 1 ATOM 6 N N . ILE A 1 2 ? -6.258 -35.287 2.254 1.00 33.72 ? 2 ILE A N 1 ATOM 7 C CA . ILE A 1 2 ? -6.758 -36.464 1.626 1.00 32.90 ? 2 ILE A CA 1 ATOM 8 C C . ILE A 1 2 ? -5.626 -37.090 0.827 1.00 32.76 ? 2 ILE A C 1 ATOM 9 O O . ILE A 1 2 ? -4.707 -36.385 0.419 1.00 33.29 ? 2 ILE A O 1 ATOM 10 C CB . ILE A 1 2 ? -8.017 -36.053 0.841 1.00 32.67 ? 2 ILE A CB 1 ATOM 11 C CG1 . ILE A 1 2 ? -9.189 -36.683 1.553 1.00 33.75 ? 2 ILE A CG1 1 ATOM 12 C CG2 . ILE A 1 2 ? -7.980 -36.427 -0.629 1.00 30.36 ? 2 ILE A CG2 1 ATOM 13 C CD1 . ILE A 1 2 ? -10.303 -35.776 1.823 1.00 36.56 ? 2 ILE A CD1 1 ATOM 14 N N . GLY A 1 3 ? -5.650 -38.413 0.672 1.00 32.33 ? 3 GLY A N 1 ATOM 15 C CA . GLY A 1 3 ? -4.668 -39.114 -0.153 1.00 31.25 ? 3 GLY A CA 1 ATOM 16 C C . GLY A 1 3 ? -3.530 -39.741 0.625 1.00 30.89 ? 3 GLY A C 1 ATOM 17 O O . GLY A 1 3 ? -3.452 -39.605 1.845 1.00 31.22 ? 3 GLY A O 1 ATOM 18 N N . PRO A 1 4 ? -2.599 -40.405 -0.078 1.00 30.52 ? 4 PRO A N 1 ATOM 19 C CA . PRO A 1 4 ? -2.501 -40.482 -1.546 1.00 29.90 ? 4 PRO A CA 1 ATOM 20 C C . PRO A 1 4 ? -3.541 -41.327 -2.281 1.00 30.09 ? 4 PRO A C 1 ATOM 21 O O . PRO A 1 4 ? -3.505 -41.423 -3.523 1.00 30.70 ? 4 PRO A O 1 ATOM 22 C CB . PRO A 1 4 ? -1.081 -41.024 -1.773 1.00 30.08 ? 4 PRO A CB 1 ATOM 23 C CG . PRO A 1 4 ? -0.746 -41.753 -0.517 1.00 30.17 ? 4 PRO A CG 1 ATOM 24 C CD . PRO A 1 4 ? -1.500 -41.111 0.609 1.00 29.82 ? 4 PRO A CD 1 ATOM 25 N N . VAL A 1 5 ? -4.448 -41.963 -1.547 1.00 30.22 ? 5 VAL A N 1 ATOM 26 C CA . VAL A 1 5 ? -5.355 -42.949 -2.138 1.00 29.86 ? 5 VAL A CA 1 ATOM 27 C C . VAL A 1 5 ? -6.704 -42.450 -1.766 1.00 30.07 ? 5 VAL A C 1 ATOM 28 O O . VAL A 1 5 ? -7.010 -42.385 -0.573 1.00 30.89 ? 5 VAL A O 1 ATOM 29 C CB . VAL A 1 5 ? -5.127 -44.379 -1.517 1.00 30.26 ? 5 VAL A CB 1 ATOM 30 C CG1 . VAL A 1 5 ? -6.293 -45.347 -1.850 1.00 29.51 ? 5 VAL A CG1 1 ATOM 31 C CG2 . VAL A 1 5 ? -3.774 -44.961 -1.951 1.00 28.50 ? 5 VAL A CG2 1 ATOM 32 N N . ALA A 1 6 ? -7.501 -42.042 -2.748 1.00 29.79 ? 6 ALA A N 1 ATOM 33 C CA . ALA A 1 6 ? -8.735 -41.264 -2.450 1.00 29.91 ? 6 ALA A CA 1 ATOM 34 C C . ALA A 1 6 ? -9.650 -41.160 -3.636 1.00 30.46 ? 6 ALA A C 1 ATOM 35 O O . ALA A 1 6 ? -9.207 -41.235 -4.810 1.00 30.93 ? 6 ALA A O 1 ATOM 36 C CB . ALA A 1 6 ? -8.389 -39.834 -1.944 1.00 28.83 ? 6 ALA A CB 1 ATOM 37 N N . ASP A 1 7 ? -10.930 -40.990 -3.335 1.00 30.87 ? 7 ASP A N 1 ATOM 38 C CA . ASP A 1 7 ? -11.896 -40.605 -4.356 1.00 30.90 ? 7 ASP A CA 1 ATOM 39 C C . ASP A 1 7 ? -11.897 -39.078 -4.539 1.00 30.79 ? 7 ASP A C 1 ATOM 40 O O . ASP A 1 7 ? -11.808 -38.306 -3.572 1.00 30.30 ? 7 ASP A O 1 ATOM 41 C CB . ASP A 1 7 ? -13.303 -41.089 -3.984 1.00 31.41 ? 7 ASP A CB 1 ATOM 42 C CG . ASP A 1 7 ? -13.469 -42.625 -4.101 1.00 33.05 ? 7 ASP A CG 1 ATOM 43 O OD1 . ASP A 1 7 ? -12.972 -43.250 -5.062 1.00 36.26 ? 7 ASP A OD1 1 ATOM 44 O OD2 . ASP A 1 7 ? -14.123 -43.214 -3.224 1.00 33.87 ? 7 ASP A OD2 1 ATOM 45 N N . LEU A 1 8 ? -11.996 -38.659 -5.798 1.00 30.24 ? 8 LEU A N 1 ATOM 46 C CA . LEU A 1 8 ? -12.156 -37.277 -6.151 1.00 29.58 ? 8 LEU A CA 1 ATOM 47 C C . LEU A 1 8 ? -13.457 -37.202 -6.924 1.00 29.87 ? 8 LEU A C 1 ATOM 48 O O . LEU A 1 8 ? -13.494 -37.525 -8.117 1.00 30.78 ? 8 LEU A O 1 ATOM 49 C CB . LEU A 1 8 ? -10.970 -36.847 -7.012 1.00 29.83 ? 8 LEU A CB 1 ATOM 50 C CG . LEU A 1 8 ? -9.569 -36.906 -6.373 1.00 30.97 ? 8 LEU A CG 1 ATOM 51 C CD1 . LEU A 1 8 ? -8.511 -36.233 -7.256 1.00 29.42 ? 8 LEU A CD1 1 ATOM 52 C CD2 . LEU A 1 8 ? -9.550 -36.293 -4.927 1.00 32.78 ? 8 LEU A CD2 1 ATOM 53 N N . THR A 1 9 ? -14.549 -36.839 -6.258 1.00 29.45 ? 9 THR A N 1 ATOM 54 C CA . THR A 1 9 ? -15.823 -36.728 -6.956 1.00 29.36 ? 9 THR A CA 1 ATOM 55 C C . THR A 1 9 ? -16.007 -35.303 -7.487 1.00 29.05 ? 9 THR A C 1 ATOM 56 O O . THR A 1 9 ? -15.917 -34.345 -6.749 1.00 29.26 ? 9 THR A O 1 ATOM 57 C CB . THR A 1 9 ? -17.030 -37.207 -6.075 1.00 29.90 ? 9 THR A CB 1 ATOM 58 O OG1 . THR A 1 9 ? -16.880 -38.599 -5.755 1.00 31.75 ? 9 THR A OG1 1 ATOM 59 C CG2 . THR A 1 9 ? -18.361 -37.056 -6.798 1.00 28.74 ? 9 THR A CG2 1 ATOM 60 N N . ILE A 1 10 ? -16.270 -35.177 -8.777 1.00 28.60 ? 10 ILE A N 1 ATOM 61 C CA . ILE A 1 10 ? -16.381 -33.893 -9.417 1.00 28.39 ? 10 ILE A CA 1 ATOM 62 C C . ILE A 1 10 ? -17.865 -33.638 -9.669 1.00 29.15 ? 10 ILE A C 1 ATOM 63 O O . ILE A 1 10 ? -18.572 -34.514 -10.185 1.00 29.78 ? 10 ILE A O 1 ATOM 64 C CB . ILE A 1 10 ? -15.608 -33.875 -10.756 1.00 28.41 ? 10 ILE A CB 1 ATOM 65 C CG1 . ILE A 1 10 ? -14.323 -34.727 -10.697 1.00 27.77 ? 10 ILE A CG1 1 ATOM 66 C CG2 . ILE A 1 10 ? -15.318 -32.454 -11.209 1.00 28.71 ? 10 ILE A CG2 1 ATOM 67 C CD1 . ILE A 1 10 ? -13.276 -34.284 -9.678 1.00 24.89 ? 10 ILE A CD1 1 ATOM 68 N N . SER A 1 11 ? -18.362 -32.461 -9.277 1.00 29.04 ? 11 SER A N 1 ATOM 69 C CA . SER A 1 11 ? -19.777 -32.136 -9.481 1.00 28.79 ? 11 SER A CA 1 ATOM 70 C C . SER A 1 11 ? -19.942 -30.646 -9.746 1.00 28.93 ? 11 SER A C 1 ATOM 71 O O . SER A 1 11 ? -18.981 -29.900 -9.652 1.00 28.82 ? 11 SER A O 1 ATOM 72 C CB . SER A 1 11 ? -20.627 -32.572 -8.278 1.00 28.51 ? 11 SER A CB 1 ATOM 73 O OG . SER A 1 11 ? -20.278 -31.828 -7.132 1.00 27.69 ? 11 SER A OG 1 ATOM 74 N N . ASN A 1 12 ? -21.146 -30.234 -10.120 1.00 29.11 ? 12 ASN A N 1 ATOM 75 C CA . ASN A 1 12 ? -21.467 -28.833 -10.255 1.00 29.61 ? 12 ASN A CA 1 ATOM 76 C C . ASN A 1 12 ? -22.214 -28.374 -9.010 1.00 30.56 ? 12 ASN A C 1 ATOM 77 O O . ASN A 1 12 ? -22.965 -29.157 -8.404 1.00 31.54 ? 12 ASN A O 1 ATOM 78 C CB . ASN A 1 12 ? -22.304 -28.588 -11.503 1.00 28.94 ? 12 ASN A CB 1 ATOM 79 C CG . ASN A 1 12 ? -21.621 -29.094 -12.791 1.00 29.11 ? 12 ASN A CG 1 ATOM 80 O OD1 . ASN A 1 12 ? -22.216 -29.881 -13.549 1.00 29.24 ? 12 ASN A OD1 1 ATOM 81 N ND2 . ASN A 1 12 ? -20.395 -28.624 -13.058 1.00 24.48 ? 12 ASN A ND2 1 ATOM 82 N N . GLY A 1 13 ? -21.984 -27.119 -8.613 1.00 30.98 ? 13 GLY A N 1 ATOM 83 C CA . GLY A 1 13 ? -22.695 -26.491 -7.503 1.00 29.89 ? 13 GLY A CA 1 ATOM 84 C C . GLY A 1 13 ? -22.450 -24.995 -7.448 1.00 29.99 ? 13 GLY A C 1 ATOM 85 O O . GLY A 1 13 ? -21.519 -24.467 -8.094 1.00 30.06 ? 13 GLY A O 1 ATOM 86 N N . ALA A 1 14 ? -23.281 -24.303 -6.671 1.00 29.62 ? 14 ALA A N 1 ATOM 87 C CA . ALA A 1 14 ? -23.111 -22.874 -6.469 1.00 29.37 ? 14 ALA A CA 1 ATOM 88 C C . ALA A 1 14 ? -22.031 -22.630 -5.402 1.00 29.14 ? 14 ALA A C 1 ATOM 89 O O . ALA A 1 14 ? -21.909 -23.394 -4.452 1.00 27.69 ? 14 ALA A O 1 ATOM 90 C CB . ALA A 1 14 ? -24.443 -22.212 -6.087 1.00 29.22 ? 14 ALA A CB 1 ATOM 91 N N . VAL A 1 15 ? -21.247 -21.572 -5.603 1.00 29.06 ? 15 VAL A N 1 ATOM 92 C CA . VAL A 1 15 ? -20.155 -21.193 -4.705 1.00 29.00 ? 15 VAL A CA 1 ATOM 93 C C . VAL A 1 15 ? -20.187 -19.690 -4.613 1.00 29.95 ? 15 VAL A C 1 ATOM 94 O O . VAL A 1 15 ? -20.765 -19.015 -5.455 1.00 30.35 ? 15 VAL A O 1 ATOM 95 C CB . VAL A 1 15 ? -18.709 -21.640 -5.220 1.00 29.17 ? 15 VAL A CB 1 ATOM 96 C CG1 . VAL A 1 15 ? -18.580 -23.159 -5.375 1.00 28.04 ? 15 VAL A CG1 1 ATOM 97 C CG2 . VAL A 1 15 ? -18.323 -20.948 -6.500 1.00 26.38 ? 15 VAL A CG2 1 ATOM 98 N N . SER A 1 16 ? -19.540 -19.146 -3.609 1.00 31.27 ? 16 SER A N 1 ATOM 99 C CA . SER A 1 16 ? -19.571 -17.698 -3.418 1.00 31.96 ? 16 SER A CA 1 ATOM 100 C C . SER A 1 16 ? -18.290 -17.266 -2.714 1.00 32.11 ? 16 SER A C 1 ATOM 101 O O . SER A 1 16 ? -18.331 -16.768 -1.590 1.00 32.66 ? 16 SER A O 1 ATOM 102 C CB . SER A 1 16 ? -20.806 -17.319 -2.593 1.00 32.11 ? 16 SER A CB 1 ATOM 103 O OG . SER A 1 16 ? -20.875 -18.132 -1.438 1.00 32.58 ? 16 SER A OG 1 ATOM 104 N N . PRO A 1 17 ? -17.136 -17.457 -3.377 1.00 32.07 ? 17 PRO A N 1 ATOM 105 C CA . PRO A 1 17 ? -15.886 -17.257 -2.647 1.00 31.62 ? 17 PRO A CA 1 ATOM 106 C C . PRO A 1 17 ? -15.519 -15.758 -2.478 1.00 31.90 ? 17 PRO A C 1 ATOM 107 O O . PRO A 1 17 ? -14.723 -15.437 -1.608 1.00 32.19 ? 17 PRO A O 1 ATOM 108 C CB . PRO A 1 17 ? -14.872 -18.012 -3.503 1.00 31.19 ? 17 PRO A CB 1 ATOM 109 C CG . PRO A 1 17 ? -15.401 -17.883 -4.900 1.00 31.15 ? 17 PRO A CG 1 ATOM 110 C CD . PRO A 1 17 ? -16.907 -17.804 -4.799 1.00 31.70 ? 17 PRO A CD 1 ATOM 111 N N . ASP A 1 18 ? -16.090 -14.849 -3.275 1.00 32.51 ? 18 ASP A N 1 ATOM 112 C CA . ASP A 1 18 ? -15.898 -13.407 -3.029 1.00 33.41 ? 18 ASP A CA 1 ATOM 113 C C . ASP A 1 18 ? -17.214 -12.743 -2.583 1.00 34.18 ? 18 ASP A C 1 ATOM 114 O O . ASP A 1 18 ? -17.413 -11.529 -2.761 1.00 33.89 ? 18 ASP A O 1 ATOM 115 C CB . ASP A 1 18 ? -15.331 -12.688 -4.250 1.00 33.11 ? 18 ASP A CB 1 ATOM 116 C CG . ASP A 1 18 ? -16.315 -12.659 -5.404 1.00 34.80 ? 18 ASP A CG 1 ATOM 117 O OD1 . ASP A 1 18 ? -17.214 -13.525 -5.403 1.00 34.74 ? 18 ASP A OD1 1 ATOM 118 O OD2 . ASP A 1 18 ? -16.207 -11.785 -6.295 1.00 33.43 ? 18 ASP A OD2 1 ATOM 119 N N . GLY A 1 19 ? -18.114 -13.542 -1.999 1.00 34.54 ? 19 GLY A N 1 ATOM 120 C CA . GLY A 1 19 ? -19.368 -12.992 -1.486 1.00 34.84 ? 19 GLY A CA 1 ATOM 121 C C . GLY A 1 19 ? -20.469 -12.774 -2.518 1.00 34.62 ? 19 GLY A C 1 ATOM 122 O O . GLY A 1 19 ? -21.554 -12.329 -2.171 1.00 35.13 ? 19 GLY A O 1 ATOM 123 N N . PHE A 1 20 ? -20.176 -13.074 -3.780 1.00 34.26 ? 20 PHE A N 1 ATOM 124 C CA . PHE A 1 20 ? -21.153 -13.135 -4.844 1.00 33.90 ? 20 PHE A CA 1 ATOM 125 C C . PHE A 1 20 ? -21.266 -14.613 -5.245 1.00 34.59 ? 20 PHE A C 1 ATOM 126 O O . PHE A 1 20 ? -20.282 -15.363 -5.137 1.00 35.20 ? 20 PHE A O 1 ATOM 127 C CB . PHE A 1 20 ? -20.598 -12.341 -5.980 1.00 33.31 ? 20 PHE A CB 1 ATOM 128 C CG . PHE A 1 20 ? -21.383 -12.431 -7.244 1.00 35.38 ? 20 PHE A CG 1 ATOM 129 C CD1 . PHE A 1 20 ? -22.450 -11.536 -7.492 1.00 36.75 ? 20 PHE A CD1 1 ATOM 130 C CD2 . PHE A 1 20 ? -21.030 -13.349 -8.230 1.00 34.71 ? 20 PHE A CD2 1 ATOM 131 C CE1 . PHE A 1 20 ? -23.165 -11.576 -8.687 1.00 35.09 ? 20 PHE A CE1 1 ATOM 132 C CE2 . PHE A 1 20 ? -21.741 -13.407 -9.426 1.00 35.90 ? 20 PHE A CE2 1 ATOM 133 C CZ . PHE A 1 20 ? -22.818 -12.509 -9.660 1.00 35.05 ? 20 PHE A CZ 1 ATOM 134 N N . SER A 1 21 ? -22.422 -15.083 -5.714 1.00 34.13 ? 21 SER A N 1 ATOM 135 C CA . SER A 1 21 ? -22.449 -16.513 -6.057 1.00 33.26 ? 21 SER A CA 1 ATOM 136 C C . SER A 1 21 ? -22.717 -16.886 -7.489 1.00 32.50 ? 21 SER A C 1 ATOM 137 O O . SER A 1 21 ? -23.462 -16.219 -8.219 1.00 32.57 ? 21 SER A O 1 ATOM 138 C CB . SER A 1 21 ? -23.320 -17.338 -5.104 1.00 33.57 ? 21 SER A CB 1 ATOM 139 O OG . SER A 1 21 ? -24.539 -16.726 -4.847 1.00 34.13 ? 21 SER A OG 1 ATOM 140 N N . ARG A 1 22 ? -22.099 -17.990 -7.874 1.00 31.51 ? 22 ARG A N 1 ATOM 141 C CA . ARG A 1 22 ? -22.249 -18.520 -9.213 1.00 30.59 ? 22 ARG A CA 1 ATOM 142 C C . ARG A 1 22 ? -22.087 -20.025 -9.230 1.00 29.97 ? 22 ARG A C 1 ATOM 143 O O . ARG A 1 22 ? -21.594 -20.625 -8.260 1.00 28.92 ? 22 ARG A O 1 ATOM 144 C CB . ARG A 1 22 ? -21.207 -17.896 -10.102 1.00 31.15 ? 22 ARG A CB 1 ATOM 145 C CG . ARG A 1 22 ? -19.768 -17.964 -9.525 1.00 30.62 ? 22 ARG A CG 1 ATOM 146 C CD . ARG A 1 22 ? -18.814 -17.828 -10.654 1.00 30.33 ? 22 ARG A CD 1 ATOM 147 N NE . ARG A 1 22 ? -18.763 -19.077 -11.410 1.00 30.84 ? 22 ARG A NE 1 ATOM 148 C CZ . ARG A 1 22 ? -17.882 -19.338 -12.366 1.00 30.44 ? 22 ARG A CZ 1 ATOM 149 N NH1 . ARG A 1 22 ? -17.909 -20.513 -12.964 1.00 31.94 ? 22 ARG A NH1 1 ATOM 150 N NH2 . ARG A 1 22 ? -16.976 -18.427 -12.724 1.00 31.13 ? 22 ARG A NH2 1 ATOM 151 N N . GLN A 1 23 ? -22.533 -20.624 -10.334 1.00 29.78 ? 23 GLN A N 1 ATOM 152 C CA . GLN A 1 23 ? -22.362 -22.053 -10.587 1.00 29.74 ? 23 GLN A CA 1 ATOM 153 C C . GLN A 1 23 ? -20.893 -22.379 -10.916 1.00 29.67 ? 23 GLN A C 1 ATOM 154 O O . GLN A 1 23 ? -20.316 -21.809 -11.827 1.00 29.64 ? 23 GLN A O 1 ATOM 155 C CB . GLN A 1 23 ? -23.232 -22.509 -11.742 1.00 29.39 ? 23 GLN A CB 1 ATOM 156 C CG . GLN A 1 23 ? -24.622 -22.934 -11.373 1.00 30.85 ? 23 GLN A CG 1 ATOM 157 C CD . GLN A 1 23 ? -24.712 -23.899 -10.203 1.00 31.98 ? 23 GLN A CD 1 ATOM 158 O OE1 . GLN A 1 23 ? -25.487 -23.665 -9.273 1.00 33.26 ? 23 GLN A OE1 1 ATOM 159 N NE2 . GLN A 1 23 ? -23.949 -24.989 -10.245 1.00 30.94 ? 23 GLN A NE2 1 ATOM 160 N N . ALA A 1 24 ? -20.293 -23.290 -10.161 1.00 29.10 ? 24 ALA A N 1 ATOM 161 C CA . ALA A 1 24 ? -18.914 -23.635 -10.397 1.00 28.56 ? 24 ALA A CA 1 ATOM 162 C C . ALA A 1 24 ? -18.753 -25.168 -10.359 1.00 28.86 ? 24 ALA A C 1 ATOM 163 O O . ALA A 1 24 ? -19.762 -25.921 -10.461 1.00 28.48 ? 24 ALA A O 1 ATOM 164 C CB . ALA A 1 24 ? -18.037 -22.965 -9.406 1.00 27.13 ? 24 ALA A CB 1 ATOM 165 N N . ILE A 1 25 ? -17.496 -25.595 -10.201 1.00 27.75 ? 25 ILE A N 1 ATOM 166 C CA . ILE A 1 25 ? -17.113 -26.977 -10.176 1.00 26.92 ? 25 ILE A CA 1 ATOM 167 C C . ILE A 1 25 ? -16.655 -27.317 -8.767 1.00 27.82 ? 25 ILE A C 1 ATOM 168 O O . ILE A 1 25 ? -15.755 -26.681 -8.212 1.00 28.48 ? 25 ILE A O 1 ATOM 169 C CB . ILE A 1 25 ? -16.013 -27.293 -11.232 1.00 26.38 ? 25 ILE A CB 1 ATOM 170 C CG1 . ILE A 1 25 ? -16.591 -27.119 -12.648 1.00 26.99 ? 25 ILE A CG1 1 ATOM 171 C CG2 . ILE A 1 25 ? -15.515 -28.715 -11.075 1.00 24.45 ? 25 ILE A CG2 1 ATOM 172 C CD1 . ILE A 1 25 ? -15.603 -27.194 -13.810 1.00 25.69 ? 25 ILE A CD1 1 ATOM 173 N N . LEU A 1 26 ? -17.289 -28.330 -8.201 1.00 27.83 ? 26 LEU A N 1 ATOM 174 C CA . LEU A 1 26 ? -17.013 -28.789 -6.871 1.00 28.20 ? 26 LEU A CA 1 ATOM 175 C C . LEU A 1 26 ? -16.168 -30.091 -6.888 1.00 28.02 ? 26 LEU A C 1 ATOM 176 O O . LEU A 1 26 ? -16.332 -30.930 -7.776 1.00 27.62 ? 26 LEU A O 1 ATOM 177 C CB . LEU A 1 26 ? -18.349 -29.063 -6.195 1.00 28.12 ? 26 LEU A CB 1 ATOM 178 C CG . LEU A 1 26 ? -18.948 -28.017 -5.271 1.00 29.61 ? 26 LEU A CG 1 ATOM 179 C CD1 . LEU A 1 26 ? -18.651 -26.633 -5.748 1.00 32.16 ? 26 LEU A CD1 1 ATOM 180 C CD2 . LEU A 1 26 ? -20.497 -28.260 -5.114 1.00 29.21 ? 26 LEU A CD2 1 ATOM 181 N N . VAL A 1 27 ? -15.292 -30.241 -5.891 1.00 27.68 ? 27 VAL A N 1 ATOM 182 C CA . VAL A 1 27 ? -14.538 -31.462 -5.658 1.00 27.45 ? 27 VAL A CA 1 ATOM 183 C C . VAL A 1 27 ? -14.763 -32.024 -4.230 1.00 29.02 ? 27 VAL A C 1 ATOM 184 O O . VAL A 1 27 ? -14.603 -31.314 -3.210 1.00 28.60 ? 27 VAL A O 1 ATOM 185 C CB . VAL A 1 27 ? -13.046 -31.258 -5.876 1.00 27.33 ? 27 VAL A CB 1 ATOM 186 C CG1 . VAL A 1 27 ? -12.336 -32.639 -5.870 1.00 25.46 ? 27 VAL A CG1 1 ATOM 187 C CG2 . VAL A 1 27 ? -12.785 -30.453 -7.166 1.00 24.86 ? 27 VAL A CG2 1 ATOM 188 N N . ASN A 1 28 ? -15.115 -33.316 -4.184 1.00 29.82 ? 28 ASN A N 1 ATOM 189 C CA . ASN A 1 28 ? -15.710 -33.934 -3.025 1.00 30.36 ? 28 ASN A CA 1 ATOM 190 C C . ASN A 1 28 ? -16.613 -32.968 -2.280 1.00 31.48 ? 28 ASN A C 1 ATOM 191 O O . ASN A 1 28 ? -16.442 -32.715 -1.069 1.00 31.86 ? 28 ASN A O 1 ATOM 192 C CB . ASN A 1 28 ? -14.627 -34.463 -2.108 1.00 30.39 ? 28 ASN A CB 1 ATOM 193 C CG . ASN A 1 28 ? -13.788 -35.500 -2.772 1.00 29.69 ? 28 ASN A CG 1 ATOM 194 O OD1 . ASN A 1 28 ? -14.264 -36.230 -3.648 1.00 27.33 ? 28 ASN A OD1 1 ATOM 195 N ND2 . ASN A 1 28 ? -12.521 -35.577 -2.368 1.00 27.51 ? 28 ASN A ND2 1 ATOM 196 N N . ASP A 1 29 ? -17.568 -32.425 -3.022 1.00 32.34 ? 29 ASP A N 1 ATOM 197 C CA . ASP A 1 29 ? -18.557 -31.450 -2.503 1.00 33.75 ? 29 ASP A CA 1 ATOM 198 C C . ASP A 1 29 ? -18.059 -30.080 -2.035 1.00 32.89 ? 29 ASP A C 1 ATOM 199 O O . ASP A 1 29 ? -18.878 -29.314 -1.574 1.00 33.16 ? 29 ASP A O 1 ATOM 200 C CB . ASP A 1 29 ? -19.425 -32.047 -1.381 1.00 33.98 ? 29 ASP A CB 1 ATOM 201 C CG . ASP A 1 29 ? -20.395 -33.066 -1.881 1.00 37.80 ? 29 ASP A CG 1 ATOM 202 O OD1 . ASP A 1 29 ? -20.979 -32.881 -2.990 1.00 37.86 ? 29 ASP A OD1 1 ATOM 203 O OD2 . ASP A 1 29 ? -20.588 -34.061 -1.133 1.00 43.69 ? 29 ASP A OD2 1 ATOM 204 N N . VAL A 1 30 ? -16.762 -29.770 -2.136 1.00 32.33 ? 30 VAL A N 1 ATOM 205 C CA . VAL A 1 30 ? -16.257 -28.485 -1.606 1.00 31.56 ? 30 VAL A CA 1 ATOM 206 C C . VAL A 1 30 ? -15.603 -27.595 -2.646 1.00 31.75 ? 30 VAL A C 1 ATOM 207 O O . VAL A 1 30 ? -15.022 -28.083 -3.603 1.00 32.40 ? 30 VAL A O 1 ATOM 208 C CB . VAL A 1 30 ? -15.279 -28.635 -0.355 1.00 31.27 ? 30 VAL A CB 1 ATOM 209 C CG1 . VAL A 1 30 ? -15.879 -29.503 0.724 1.00 29.65 ? 30 VAL A CG1 1 ATOM 210 C CG2 . VAL A 1 30 ? -13.929 -29.145 -0.754 1.00 29.02 ? 30 VAL A CG2 1 ATOM 211 N N . PHE A 1 31 ? -15.747 -26.284 -2.460 1.00 31.67 ? 31 PHE A N 1 ATOM 212 C CA . PHE A 1 31 ? -14.929 -25.304 -3.123 1.00 31.05 ? 31 PHE A CA 1 ATOM 213 C C . PHE A 1 31 ? -14.232 -24.454 -2.047 1.00 31.45 ? 31 PHE A C 1 ATOM 214 O O . PHE A 1 31 ? -14.839 -24.134 -1.020 1.00 32.08 ? 31 PHE A O 1 ATOM 215 C CB . PHE A 1 31 ? -15.764 -24.414 -4.035 1.00 31.06 ? 31 PHE A CB 1 ATOM 216 C CG . PHE A 1 31 ? -14.943 -23.362 -4.752 1.00 30.04 ? 31 PHE A CG 1 ATOM 217 C CD1 . PHE A 1 31 ? -14.585 -22.182 -4.113 1.00 29.36 ? 31 PHE A CD1 1 ATOM 218 C CD2 . PHE A 1 31 ? -14.492 -23.582 -6.034 1.00 28.41 ? 31 PHE A CD2 1 ATOM 219 C CE1 . PHE A 1 31 ? -13.788 -21.238 -4.765 1.00 32.50 ? 31 PHE A CE1 1 ATOM 220 C CE2 . PHE A 1 31 ? -13.685 -22.647 -6.698 1.00 31.12 ? 31 PHE A CE2 1 ATOM 221 C CZ . PHE A 1 31 ? -13.336 -21.473 -6.069 1.00 31.02 ? 31 PHE A CZ 1 ATOM 222 N N . PRO A 1 32 ? -12.948 -24.107 -2.257 1.00 31.40 ? 32 PRO A N 1 ATOM 223 C CA . PRO A 1 32 ? -12.082 -24.544 -3.364 1.00 31.21 ? 32 PRO A CA 1 ATOM 224 C C . PRO A 1 32 ? -11.763 -26.032 -3.193 1.00 31.11 ? 32 PRO A C 1 ATOM 225 O O . PRO A 1 32 ? -12.177 -26.649 -2.196 1.00 31.09 ? 32 PRO A O 1 ATOM 226 C CB . PRO A 1 32 ? -10.820 -23.721 -3.151 1.00 30.71 ? 32 PRO A CB 1 ATOM 227 C CG . PRO A 1 32 ? -10.778 -23.522 -1.638 1.00 30.83 ? 32 PRO A CG 1 ATOM 228 C CD . PRO A 1 32 ? -12.215 -23.227 -1.324 1.00 31.73 ? 32 PRO A CD 1 ATOM 229 N N . SER A 1 33 ? -11.013 -26.594 -4.132 1.00 30.30 ? 33 SER A N 1 ATOM 230 C CA . SER A 1 33 ? -10.765 -28.026 -4.128 1.00 29.62 ? 33 SER A CA 1 ATOM 231 C C . SER A 1 33 ? -9.861 -28.428 -2.972 1.00 29.39 ? 33 SER A C 1 ATOM 232 O O . SER A 1 33 ? -8.987 -27.655 -2.547 1.00 29.39 ? 33 SER A O 1 ATOM 233 C CB . SER A 1 33 ? -10.199 -28.471 -5.469 1.00 29.53 ? 33 SER A CB 1 ATOM 234 O OG . SER A 1 33 ? -10.819 -27.725 -6.492 1.00 28.06 ? 33 SER A OG 1 ATOM 235 N N . PRO A 1 34 ? -10.089 -29.633 -2.439 1.00 28.67 ? 34 PRO A N 1 ATOM 236 C CA . PRO A 1 34 ? -9.349 -30.092 -1.280 1.00 27.84 ? 34 PRO A CA 1 ATOM 237 C C . PRO A 1 34 ? -7.870 -30.390 -1.578 1.00 27.42 ? 34 PRO A C 1 ATOM 238 O O . PRO A 1 34 ? -7.498 -30.802 -2.694 1.00 27.21 ? 34 PRO A O 1 ATOM 239 C CB . PRO A 1 34 ? -10.092 -31.379 -0.875 1.00 27.20 ? 34 PRO A CB 1 ATOM 240 C CG . PRO A 1 34 ? -10.678 -31.877 -2.114 1.00 27.85 ? 34 PRO A CG 1 ATOM 241 C CD . PRO A 1 34 ? -11.061 -30.640 -2.900 1.00 29.03 ? 34 PRO A CD 1 ATOM 242 N N . LEU A 1 35 ? -7.064 -30.180 -0.548 1.00 26.81 ? 35 LEU A N 1 ATOM 243 C CA . LEU A 1 35 ? -5.669 -30.490 -0.531 1.00 26.62 ? 35 LEU A CA 1 ATOM 244 C C . LEU A 1 35 ? -5.525 -31.992 -0.519 1.00 26.89 ? 35 LEU A C 1 ATOM 245 O O . LEU A 1 35 ? -6.260 -32.694 0.172 1.00 27.71 ? 35 LEU A O 1 ATOM 246 C CB . LEU A 1 35 ? -5.059 -29.904 0.739 1.00 27.38 ? 35 LEU A CB 1 ATOM 247 C CG . LEU A 1 35 ? -3.638 -30.262 1.150 1.00 27.44 ? 35 LEU A CG 1 ATOM 248 C CD1 . LEU A 1 35 ? -2.616 -29.881 0.034 1.00 26.33 ? 35 LEU A CD1 1 ATOM 249 C CD2 . LEU A 1 35 ? -3.319 -29.652 2.510 1.00 25.43 ? 35 LEU A CD2 1 ATOM 250 N N . ILE A 1 36 ? -4.598 -32.473 -1.330 1.00 26.26 ? 36 ILE A N 1 ATOM 251 C CA . ILE A 1 36 ? -4.204 -33.860 -1.361 1.00 25.66 ? 36 ILE A CA 1 ATOM 252 C C . ILE A 1 36 ? -2.763 -33.905 -0.794 1.00 25.94 ? 36 ILE A C 1 ATOM 253 O O . ILE A 1 36 ? -1.969 -33.022 -1.074 1.00 26.89 ? 36 ILE A O 1 ATOM 254 C CB . ILE A 1 36 ? -4.268 -34.412 -2.824 1.00 24.80 ? 36 ILE A CB 1 ATOM 255 C CG1 . ILE A 1 36 ? -5.687 -34.319 -3.379 1.00 25.01 ? 36 ILE A CG1 1 ATOM 256 C CG2 . ILE A 1 36 ? -3.813 -35.878 -2.906 1.00 25.70 ? 36 ILE A CG2 1 ATOM 257 C CD1 . ILE A 1 36 ? -5.797 -34.712 -4.846 1.00 24.52 ? 36 ILE A CD1 1 ATOM 258 N N . THR A 1 37 ? -2.420 -34.913 -0.011 1.00 25.97 ? 37 THR A N 1 ATOM 259 C CA . THR A 1 37 ? -1.035 -35.097 0.412 1.00 26.13 ? 37 THR A CA 1 ATOM 260 C C . THR A 1 37 ? -0.561 -36.557 0.250 1.00 27.19 ? 37 THR A C 1 ATOM 261 O O . THR A 1 37 ? -1.380 -37.486 0.040 1.00 26.20 ? 37 THR A O 1 ATOM 262 C CB . THR A 1 37 ? -0.831 -34.625 1.872 1.00 26.31 ? 37 THR A CB 1 ATOM 263 O OG1 . THR A 1 37 ? -1.610 -35.440 2.757 1.00 26.39 ? 37 THR A OG1 1 ATOM 264 C CG2 . THR A 1 37 ? -1.265 -33.132 2.059 1.00 25.85 ? 37 THR A CG2 1 ATOM 265 N N . GLY A 1 38 ? 0.768 -36.724 0.319 1.00 28.14 ? 38 GLY A N 1 ATOM 266 C CA . GLY A 1 38 ? 1.484 -38.007 0.347 1.00 29.12 ? 38 GLY A CA 1 ATOM 267 C C . GLY A 1 38 ? 2.931 -37.745 0.779 1.00 30.65 ? 38 GLY A C 1 ATOM 268 O O . GLY A 1 38 ? 3.307 -36.587 1.094 1.00 31.08 ? 38 GLY A O 1 ATOM 269 N N . ASN A 1 39 ? 3.758 -38.786 0.793 1.00 30.75 ? 39 ASN A N 1 ATOM 270 C CA . ASN A 1 39 ? 5.171 -38.631 1.117 1.00 31.50 ? 39 ASN A CA 1 ATOM 271 C C . ASN A 1 39 ? 6.033 -38.979 -0.068 1.00 32.41 ? 39 ASN A C 1 ATOM 272 O O . ASN A 1 39 ? 5.573 -39.659 -0.959 1.00 32.90 ? 39 ASN A O 1 ATOM 273 C CB . ASN A 1 39 ? 5.559 -39.515 2.291 1.00 31.26 ? 39 ASN A CB 1 ATOM 274 C CG . ASN A 1 39 ? 4.802 -39.171 3.561 1.00 31.81 ? 39 ASN A CG 1 ATOM 275 O OD1 . ASN A 1 39 ? 4.199 -40.044 4.164 1.00 28.08 ? 39 ASN A OD1 1 ATOM 276 N ND2 . ASN A 1 39 ? 4.816 -37.887 3.965 1.00 33.37 ? 39 ASN A ND2 1 ATOM 277 N N . LYS A 1 40 ? 7.274 -38.495 -0.104 1.00 33.96 ? 40 LYS A N 1 ATOM 278 C CA . LYS A 1 40 ? 8.223 -38.909 -1.141 1.00 35.20 ? 40 LYS A CA 1 ATOM 279 C C . LYS A 1 40 ? 8.146 -40.423 -1.242 1.00 34.76 ? 40 LYS A C 1 ATOM 280 O O . LYS A 1 40 ? 8.270 -41.119 -0.222 1.00 34.22 ? 40 LYS A O 1 ATOM 281 C CB . LYS A 1 40 ? 9.647 -38.416 -0.826 1.00 36.47 ? 40 LYS A CB 1 ATOM 282 C CG . LYS A 1 40 ? 10.819 -39.357 -1.224 1.00 39.76 ? 40 LYS A CG 1 ATOM 283 C CD . LYS A 1 40 ? 11.482 -40.080 0.036 1.00 45.50 ? 40 LYS A CD 1 ATOM 284 C CE . LYS A 1 40 ? 12.350 -41.343 -0.316 1.00 45.30 ? 40 LYS A CE 1 ATOM 285 N NZ . LYS A 1 40 ? 11.560 -42.672 -0.353 1.00 45.56 ? 40 LYS A NZ 1 ATOM 286 N N . GLY A 1 41 ? 7.860 -40.916 -2.452 1.00 34.26 ? 41 GLY A N 1 ATOM 287 C CA . GLY A 1 41 ? 7.883 -42.362 -2.726 1.00 33.63 ? 41 GLY A CA 1 ATOM 288 C C . GLY A 1 41 ? 6.533 -43.024 -2.894 1.00 33.66 ? 41 GLY A C 1 ATOM 289 O O . GLY A 1 41 ? 6.438 -44.040 -3.565 1.00 33.69 ? 41 GLY A O 1 ATOM 290 N N . ASP A 1 42 ? 5.495 -42.453 -2.275 1.00 33.50 ? 42 ASP A N 1 ATOM 291 C CA . ASP A 1 42 ? 4.114 -42.969 -2.312 1.00 32.79 ? 42 ASP A CA 1 ATOM 292 C C . ASP A 1 42 ? 3.593 -43.227 -3.708 1.00 32.82 ? 42 ASP A C 1 ATOM 293 O O . ASP A 1 42 ? 3.973 -42.535 -4.672 1.00 33.04 ? 42 ASP A O 1 ATOM 294 C CB . ASP A 1 42 ? 3.145 -41.998 -1.626 1.00 32.47 ? 42 ASP A CB 1 ATOM 295 C CG . ASP A 1 42 ? 3.164 -42.107 -0.112 1.00 32.72 ? 42 ASP A CG 1 ATOM 296 O OD1 . ASP A 1 42 ? 3.857 -42.990 0.446 1.00 32.73 ? 42 ASP A OD1 1 ATOM 297 O OD2 . ASP A 1 42 ? 2.469 -41.298 0.529 1.00 32.05 ? 42 ASP A OD2 1 ATOM 298 N N . ARG A 1 43 ? 2.738 -44.244 -3.792 1.00 32.48 ? 43 ARG A N 1 ATOM 299 C CA . ARG A 1 43 ? 1.855 -44.497 -4.926 1.00 32.58 ? 43 ARG A CA 1 ATOM 300 C C . ARG A 1 43 ? 0.598 -43.690 -4.706 1.00 31.69 ? 43 ARG A C 1 ATOM 301 O O . ARG A 1 43 ? -0.016 -43.796 -3.656 1.00 32.25 ? 43 ARG A O 1 ATOM 302 C CB . ARG A 1 43 ? 1.471 -45.989 -4.962 1.00 33.32 ? 43 ARG A CB 1 ATOM 303 C CG . ARG A 1 43 ? 0.373 -46.375 -5.961 1.00 34.77 ? 43 ARG A CG 1 ATOM 304 C CD . ARG A 1 43 ? 0.394 -47.872 -6.165 1.00 37.40 ? 43 ARG A CD 1 ATOM 305 N NE . ARG A 1 43 ? -0.231 -48.282 -7.422 1.00 43.02 ? 43 ARG A NE 1 ATOM 306 C CZ . ARG A 1 43 ? -0.735 -49.500 -7.660 1.00 45.44 ? 43 ARG A CZ 1 ATOM 307 N NH1 . ARG A 1 43 ? -1.260 -49.791 -8.840 1.00 43.52 ? 43 ARG A NH1 1 ATOM 308 N NH2 . ARG A 1 43 ? -0.702 -50.449 -6.723 1.00 48.15 ? 43 ARG A NH2 1 ATOM 309 N N . PHE A 1 44 ? 0.213 -42.888 -5.683 1.00 31.00 ? 44 PHE A N 1 ATOM 310 C CA . PHE A 1 44 ? -1.037 -42.148 -5.617 1.00 30.36 ? 44 PHE A CA 1 ATOM 311 C C . PHE A 1 44 ? -2.099 -42.883 -6.390 1.00 30.31 ? 44 PHE A C 1 ATOM 312 O O . PHE A 1 44 ? -1.871 -43.313 -7.524 1.00 29.97 ? 44 PHE A O 1 ATOM 313 C CB . PHE A 1 44 ? -0.867 -40.755 -6.222 1.00 30.95 ? 44 PHE A CB 1 ATOM 314 C CG . PHE A 1 44 ? -0.287 -39.750 -5.272 1.00 29.88 ? 44 PHE A CG 1 ATOM 315 C CD1 . PHE A 1 44 ? 1.073 -39.686 -5.066 1.00 26.85 ? 44 PHE A CD1 1 ATOM 316 C CD2 . PHE A 1 44 ? -1.116 -38.878 -4.592 1.00 29.89 ? 44 PHE A CD2 1 ATOM 317 C CE1 . PHE A 1 44 ? 1.596 -38.781 -4.217 1.00 29.12 ? 44 PHE A CE1 1 ATOM 318 C CE2 . PHE A 1 44 ? -0.601 -37.959 -3.719 1.00 31.75 ? 44 PHE A CE2 1 ATOM 319 C CZ . PHE A 1 44 ? 0.765 -37.901 -3.540 1.00 31.88 ? 44 PHE A CZ 1 ATOM 320 N N . GLN A 1 45 ? -3.268 -43.046 -5.791 1.00 30.32 ? 45 GLN A N 1 ATOM 321 C CA . GLN A 1 45 ? -4.357 -43.640 -6.540 1.00 30.60 ? 45 GLN A CA 1 ATOM 322 C C . GLN A 1 45 ? -5.556 -42.742 -6.394 1.00 30.36 ? 45 GLN A C 1 ATOM 323 O O . GLN A 1 45 ? -6.259 -42.771 -5.381 1.00 31.07 ? 45 GLN A O 1 ATOM 324 C CB . GLN A 1 45 ? -4.661 -45.018 -5.996 1.00 31.55 ? 45 GLN A CB 1 ATOM 325 C CG . GLN A 1 45 ? -3.440 -45.892 -5.807 1.00 32.91 ? 45 GLN A CG 1 ATOM 326 C CD . GLN A 1 45 ? -3.821 -47.331 -5.647 1.00 35.90 ? 45 GLN A CD 1 ATOM 327 O OE1 . GLN A 1 45 ? -3.904 -47.846 -4.520 1.00 34.37 ? 45 GLN A OE1 1 ATOM 328 N NE2 . GLN A 1 45 ? -4.071 -48.002 -6.775 1.00 36.54 ? 45 GLN A NE2 1 ATOM 329 N N . LEU A 1 46 ? -5.768 -41.894 -7.381 1.00 29.50 ? 46 LEU A N 1 ATOM 330 C CA . LEU A 1 46 ? -6.803 -40.902 -7.237 1.00 29.12 ? 46 LEU A CA 1 ATOM 331 C C . LEU A 1 46 ? -7.877 -41.304 -8.200 1.00 28.89 ? 46 LEU A C 1 ATOM 332 O O . LEU A 1 46 ? -7.660 -41.304 -9.386 1.00 29.58 ? 46 LEU A O 1 ATOM 333 C CB . LEU A 1 46 ? -6.233 -39.482 -7.446 1.00 28.70 ? 46 LEU A CB 1 ATOM 334 C CG . LEU A 1 46 ? -5.100 -39.271 -6.414 1.00 27.74 ? 46 LEU A CG 1 ATOM 335 C CD1 . LEU A 1 46 ? -4.031 -38.429 -6.956 1.00 28.48 ? 46 LEU A CD1 1 ATOM 336 C CD2 . LEU A 1 46 ? -5.561 -38.717 -5.082 1.00 25.96 ? 46 LEU A CD2 1 ATOM 337 N N . ASN A 1 47 ? -9.012 -41.733 -7.678 1.00 29.01 ? 47 ASN A N 1 ATOM 338 C CA . ASN A 1 47 ? -10.071 -42.264 -8.514 1.00 29.34 ? 47 ASN A CA 1 ATOM 339 C C . ASN A 1 47 ? -11.017 -41.126 -8.661 1.00 29.75 ? 47 ASN A C 1 ATOM 340 O O . ASN A 1 47 ? -11.613 -40.674 -7.671 1.00 30.29 ? 47 ASN A O 1 ATOM 341 C CB . ASN A 1 47 ? -10.736 -43.496 -7.878 1.00 29.44 ? 47 ASN A CB 1 ATOM 342 C CG . ASN A 1 47 ? -11.841 -44.107 -8.750 1.00 31.43 ? 47 ASN A CG 1 ATOM 343 O OD1 . ASN A 1 47 ? -11.751 -44.135 -9.988 1.00 32.36 ? 47 ASN A OD1 1 ATOM 344 N ND2 . ASN A 1 47 ? -12.895 -44.611 -8.097 1.00 30.56 ? 47 ASN A ND2 1 ATOM 345 N N . VAL A 1 48 ? -11.118 -40.646 -9.902 1.00 29.84 ? 48 VAL A N 1 ATOM 346 C CA . VAL A 1 48 ? -11.774 -39.405 -10.245 1.00 29.30 ? 48 VAL A CA 1 ATOM 347 C C . VAL A 1 48 ? -13.172 -39.655 -10.799 1.00 29.86 ? 48 VAL A C 1 ATOM 348 O O . VAL A 1 48 ? -13.339 -40.065 -11.949 1.00 30.15 ? 48 VAL A O 1 ATOM 349 C CB . VAL A 1 48 ? -10.926 -38.663 -11.239 1.00 28.65 ? 48 VAL A CB 1 ATOM 350 C CG1 . VAL A 1 48 ? -11.744 -37.617 -12.011 1.00 28.75 ? 48 VAL A CG1 1 ATOM 351 C CG2 . VAL A 1 48 ? -9.783 -38.007 -10.501 1.00 30.39 ? 48 VAL A CG2 1 ATOM 352 N N . ILE A 1 49 ? -14.181 -39.387 -9.979 1.00 30.26 ? 49 ILE A N 1 ATOM 353 C CA . ILE A 1 49 ? -15.555 -39.753 -10.307 1.00 30.71 ? 49 ILE A CA 1 ATOM 354 C C . ILE A 1 49 ? -16.294 -38.534 -10.828 1.00 31.00 ? 49 ILE A C 1 ATOM 355 O O . ILE A 1 49 ? -16.646 -37.653 -10.067 1.00 31.91 ? 49 ILE A O 1 ATOM 356 C CB . ILE A 1 49 ? -16.256 -40.348 -9.076 1.00 30.57 ? 49 ILE A CB 1 ATOM 357 C CG1 . ILE A 1 49 ? -15.544 -41.631 -8.628 1.00 30.32 ? 49 ILE A CG1 1 ATOM 358 C CG2 . ILE A 1 49 ? -17.717 -40.658 -9.360 1.00 31.47 ? 49 ILE A CG2 1 ATOM 359 C CD1 . ILE A 1 49 ? -15.551 -41.801 -7.090 1.00 30.61 ? 49 ILE A CD1 1 ATOM 360 N N . ASP A 1 50 ? -16.534 -38.496 -12.129 1.00 30.71 ? 50 ASP A N 1 ATOM 361 C CA . ASP A 1 50 ? -17.139 -37.351 -12.778 1.00 30.54 ? 50 ASP A CA 1 ATOM 362 C C . ASP A 1 50 ? -18.685 -37.328 -12.777 1.00 31.02 ? 50 ASP A C 1 ATOM 363 O O . ASP A 1 50 ? -19.307 -37.962 -13.609 1.00 31.82 ? 50 ASP A O 1 ATOM 364 C CB . ASP A 1 50 ? -16.614 -37.276 -14.202 1.00 29.60 ? 50 ASP A CB 1 ATOM 365 C CG . ASP A 1 50 ? -17.298 -36.230 -15.004 1.00 31.13 ? 50 ASP A CG 1 ATOM 366 O OD1 . ASP A 1 50 ? -17.981 -35.359 -14.411 1.00 31.73 ? 50 ASP A OD1 1 ATOM 367 O OD2 . ASP A 1 50 ? -17.164 -36.267 -16.242 1.00 33.04 ? 50 ASP A OD2 1 ATOM 368 N N . ASN A 1 51 ? -19.302 -36.554 -11.882 1.00 31.37 ? 51 ASN A N 1 ATOM 369 C CA . ASN A 1 51 ? -20.774 -36.416 -11.830 1.00 30.88 ? 51 ASN A CA 1 ATOM 370 C C . ASN A 1 51 ? -21.324 -35.062 -12.332 1.00 31.22 ? 51 ASN A C 1 ATOM 371 O O . ASN A 1 51 ? -22.386 -34.603 -11.893 1.00 31.39 ? 51 ASN A O 1 ATOM 372 C CB . ASN A 1 51 ? -21.285 -36.748 -10.432 1.00 30.24 ? 51 ASN A CB 1 ATOM 373 C CG . ASN A 1 51 ? -21.033 -38.197 -10.073 1.00 31.71 ? 51 ASN A CG 1 ATOM 374 O OD1 . ASN A 1 51 ? -21.018 -39.052 -10.963 1.00 34.64 ? 51 ASN A OD1 1 ATOM 375 N ND2 . ASN A 1 51 ? -20.829 -38.493 -8.786 1.00 27.78 ? 51 ASN A ND2 1 ATOM 376 N N . MET A 1 52 ? -20.620 -34.439 -13.271 1.00 30.79 ? 52 MET A N 1 ATOM 377 C CA . MET A 1 52 ? -21.004 -33.128 -13.740 1.00 31.14 ? 52 MET A CA 1 ATOM 378 C C . MET A 1 52 ? -22.150 -33.209 -14.733 1.00 31.88 ? 52 MET A C 1 ATOM 379 O O . MET A 1 52 ? -22.206 -34.143 -15.562 1.00 31.75 ? 52 MET A O 1 ATOM 380 C CB . MET A 1 52 ? -19.806 -32.402 -14.369 1.00 31.37 ? 52 MET A CB 1 ATOM 381 C CG . MET A 1 52 ? -18.814 -31.870 -13.320 1.00 32.63 ? 52 MET A CG 1 ATOM 382 S SD . MET A 1 52 ? -17.542 -30.701 -13.826 1.00 31.06 ? 52 MET A SD 1 ATOM 383 C CE . MET A 1 52 ? -16.669 -31.624 -15.078 1.00 34.30 ? 52 MET A CE 1 ATOM 384 N N . THR A 1 53 ? -23.045 -32.215 -14.673 1.00 32.00 ? 53 THR A N 1 ATOM 385 C CA . THR A 1 53 ? -24.249 -32.213 -15.505 1.00 32.63 ? 53 THR A CA 1 ATOM 386 C C . THR A 1 53 ? -24.354 -31.015 -16.423 1.00 32.98 ? 53 THR A C 1 ATOM 387 O O . THR A 1 53 ? -25.270 -30.938 -17.245 1.00 33.42 ? 53 THR A O 1 ATOM 388 C CB . THR A 1 53 ? -25.536 -32.292 -14.662 1.00 32.73 ? 53 THR A CB 1 ATOM 389 O OG1 . THR A 1 53 ? -25.679 -31.102 -13.863 1.00 34.07 ? 53 THR A OG1 1 ATOM 390 C CG2 . THR A 1 53 ? -25.545 -33.570 -13.797 1.00 31.21 ? 53 THR A CG2 1 ATOM 391 N N . ASN A 1 54 ? -23.377 -30.119 -16.305 1.00 33.11 ? 54 ASN A N 1 ATOM 392 C CA . ASN A 1 54 ? -23.441 -28.773 -16.830 1.00 32.68 ? 54 ASN A CA 1 ATOM 393 C C . ASN A 1 54 ? -22.609 -28.586 -18.073 1.00 32.65 ? 54 ASN A C 1 ATOM 394 O O . ASN A 1 54 ? -21.394 -28.425 -18.010 1.00 32.87 ? 54 ASN A O 1 ATOM 395 C CB . ASN A 1 54 ? -22.885 -27.858 -15.766 1.00 32.83 ? 54 ASN A CB 1 ATOM 396 C CG . ASN A 1 54 ? -23.358 -26.461 -15.909 1.00 34.74 ? 54 ASN A CG 1 ATOM 397 O OD1 . ASN A 1 54 ? -23.159 -25.810 -16.940 1.00 35.87 ? 54 ASN A OD1 1 ATOM 398 N ND2 . ASN A 1 54 ? -23.998 -25.966 -14.855 1.00 37.02 ? 54 ASN A ND2 1 ATOM 399 N N . HIS A 1 55 ? -23.256 -28.548 -19.216 1.00 32.79 ? 55 HIS A N 1 ATOM 400 C CA . HIS A 1 55 ? -22.497 -28.531 -20.426 1.00 32.30 ? 55 HIS A CA 1 ATOM 401 C C . HIS A 1 55 ? -21.669 -27.240 -20.566 1.00 32.64 ? 55 HIS A C 1 ATOM 402 O O . HIS A 1 55 ? -20.529 -27.317 -21.042 1.00 32.86 ? 55 HIS A O 1 ATOM 403 C CB . HIS A 1 55 ? -23.371 -28.847 -21.649 1.00 32.06 ? 55 HIS A CB 1 ATOM 404 C CG . HIS A 1 55 ? -22.598 -28.873 -22.931 1.00 34.47 ? 55 HIS A CG 1 ATOM 405 N ND1 . HIS A 1 55 ? -21.522 -29.710 -23.129 1.00 35.65 ? 55 HIS A ND1 1 ATOM 406 C CD2 . HIS A 1 55 ? -22.693 -28.110 -24.051 1.00 36.19 ? 55 HIS A CD2 1 ATOM 407 C CE1 . HIS A 1 55 ? -21.007 -29.485 -24.327 1.00 37.04 ? 55 HIS A CE1 1 ATOM 408 N NE2 . HIS A 1 55 ? -21.698 -28.518 -24.908 1.00 36.26 ? 55 HIS A NE2 1 ATOM 409 N N . THR A 1 56 ? -22.205 -26.076 -20.142 1.00 31.79 ? 56 THR A N 1 ATOM 410 C CA . THR A 1 56 ? -21.472 -24.791 -20.278 1.00 30.96 ? 56 THR A CA 1 ATOM 411 C C . THR A 1 56 ? -20.061 -24.799 -19.656 1.00 30.09 ? 56 THR A C 1 ATOM 412 O O . THR A 1 56 ? -19.150 -24.133 -20.138 1.00 29.89 ? 56 THR A O 1 ATOM 413 C CB . THR A 1 56 ? -22.251 -23.607 -19.681 1.00 31.13 ? 56 THR A CB 1 ATOM 414 O OG1 . THR A 1 56 ? -23.589 -23.596 -20.199 1.00 33.51 ? 56 THR A OG1 1 ATOM 415 C CG2 . THR A 1 56 ? -21.580 -22.279 -20.046 1.00 30.77 ? 56 THR A CG2 1 ATOM 416 N N . MET A 1 57 ? -19.904 -25.551 -18.575 1.00 29.58 ? 57 MET A N 1 ATOM 417 C CA . MET A 1 57 ? -18.608 -25.747 -17.896 1.00 28.67 ? 57 MET A CA 1 ATOM 418 C C . MET A 1 57 ? -18.011 -27.112 -18.253 1.00 27.77 ? 57 MET A C 1 ATOM 419 O O . MET A 1 57 ? -16.969 -27.503 -17.721 1.00 27.56 ? 57 MET A O 1 ATOM 420 C CB . MET A 1 57 ? -18.769 -25.574 -16.371 1.00 28.33 ? 57 MET A CB 1 ATOM 421 C CG . MET A 1 57 ? -19.369 -24.198 -16.037 1.00 28.69 ? 57 MET A CG 1 ATOM 422 S SD . MET A 1 57 ? -19.407 -23.679 -14.317 1.00 28.94 ? 57 MET A SD 1 ATOM 423 C CE . MET A 1 57 ? -20.445 -24.985 -13.626 1.00 29.39 ? 57 MET A CE 1 ATOM 424 N N . LEU A 1 58 ? -18.670 -27.803 -19.183 1.00 26.86 ? 58 LEU A N 1 ATOM 425 C CA . LEU A 1 58 ? -18.229 -29.103 -19.709 1.00 26.83 ? 58 LEU A CA 1 ATOM 426 C C . LEU A 1 58 ? -18.456 -30.278 -18.775 1.00 26.35 ? 58 LEU A C 1 ATOM 427 O O . LEU A 1 58 ? -17.900 -30.346 -17.692 1.00 26.34 ? 58 LEU A O 1 ATOM 428 C CB . LEU A 1 58 ? -16.772 -29.076 -20.195 1.00 26.81 ? 58 LEU A CB 1 ATOM 429 C CG . LEU A 1 58 ? -16.405 -28.086 -21.304 1.00 26.98 ? 58 LEU A CG 1 ATOM 430 C CD1 . LEU A 1 58 ? -14.870 -28.075 -21.455 1.00 22.71 ? 58 LEU A CD1 1 ATOM 431 C CD2 . LEU A 1 58 ? -17.116 -28.472 -22.624 1.00 25.87 ? 58 LEU A CD2 1 ATOM 432 N N . LYS A 1 59 ? -19.274 -31.206 -19.237 1.00 26.55 ? 59 LYS A N 1 ATOM 433 C CA . LYS A 1 59 ? -19.643 -32.384 -18.502 1.00 27.74 ? 59 LYS A CA 1 ATOM 434 C C . LYS A 1 59 ? -18.463 -33.329 -18.290 1.00 28.85 ? 59 LYS A C 1 ATOM 435 O O . LYS A 1 59 ? -18.352 -33.962 -17.210 1.00 29.92 ? 59 LYS A O 1 ATOM 436 C CB . LYS A 1 59 ? -20.785 -33.102 -19.214 1.00 27.52 ? 59 LYS A CB 1 ATOM 437 C CG . LYS A 1 59 ? -22.091 -32.399 -19.066 1.00 28.96 ? 59 LYS A CG 1 ATOM 438 C CD . LYS A 1 59 ? -23.109 -32.951 -19.990 1.00 32.52 ? 59 LYS A CD 1 ATOM 439 C CE . LYS A 1 59 ? -24.495 -32.894 -19.362 1.00 35.17 ? 59 LYS A CE 1 ATOM 440 N NZ . LYS A 1 59 ? -25.567 -32.939 -20.408 1.00 36.54 ? 59 LYS A NZ 1 ATOM 441 N N . SER A 1 60 ? -17.589 -33.412 -19.300 1.00 28.73 ? 60 SER A N 1 ATOM 442 C CA . SER A 1 60 ? -16.396 -34.254 -19.238 1.00 29.40 ? 60 SER A CA 1 ATOM 443 C C . SER A 1 60 ? -15.314 -33.566 -18.412 1.00 29.40 ? 60 SER A C 1 ATOM 444 O O . SER A 1 60 ? -15.428 -32.383 -18.085 1.00 30.21 ? 60 SER A O 1 ATOM 445 C CB . SER A 1 60 ? -15.866 -34.550 -20.646 1.00 29.28 ? 60 SER A CB 1 ATOM 446 O OG . SER A 1 60 ? -16.941 -34.789 -21.559 1.00 32.47 ? 60 SER A OG 1 ATOM 447 N N . THR A 1 61 ? -14.265 -34.294 -18.051 1.00 28.38 ? 61 THR A N 1 ATOM 448 C CA . THR A 1 61 ? -13.202 -33.667 -17.309 1.00 27.38 ? 61 THR A CA 1 ATOM 449 C C . THR A 1 61 ? -11.909 -34.400 -17.605 1.00 27.73 ? 61 THR A C 1 ATOM 450 O O . THR A 1 61 ? -11.917 -35.440 -18.270 1.00 28.15 ? 61 THR A O 1 ATOM 451 C CB . THR A 1 61 ? -13.491 -33.667 -15.816 1.00 27.08 ? 61 THR A CB 1 ATOM 452 O OG1 . THR A 1 61 ? -12.524 -32.848 -15.163 1.00 28.68 ? 61 THR A OG1 1 ATOM 453 C CG2 . THR A 1 61 ? -13.425 -35.088 -15.212 1.00 25.84 ? 61 THR A CG2 1 ATOM 454 N N . SER A 1 62 ? -10.798 -33.885 -17.114 1.00 26.89 ? 62 SER A N 1 ATOM 455 C CA . SER A 1 62 ? -9.576 -34.626 -17.214 1.00 27.57 ? 62 SER A CA 1 ATOM 456 C C . SER A 1 62 ? -8.603 -33.927 -16.330 1.00 27.34 ? 62 SER A C 1 ATOM 457 O O . SER A 1 62 ? -8.567 -32.706 -16.348 1.00 27.81 ? 62 SER A O 1 ATOM 458 C CB . SER A 1 62 ? -9.055 -34.579 -18.635 1.00 28.23 ? 62 SER A CB 1 ATOM 459 O OG . SER A 1 62 ? -7.769 -35.130 -18.654 1.00 31.44 ? 62 SER A OG 1 ATOM 460 N N . ILE A 1 63 ? -7.819 -34.675 -15.555 1.00 26.71 ? 63 ILE A N 1 ATOM 461 C CA . ILE A 1 63 ? -7.076 -34.054 -14.462 1.00 26.40 ? 63 ILE A CA 1 ATOM 462 C C . ILE A 1 63 ? -5.577 -34.234 -14.597 1.00 26.02 ? 63 ILE A C 1 ATOM 463 O O . ILE A 1 63 ? -5.079 -35.360 -14.777 1.00 25.67 ? 63 ILE A O 1 ATOM 464 C CB . ILE A 1 63 ? -7.541 -34.541 -13.059 1.00 26.64 ? 63 ILE A CB 1 ATOM 465 C CG1 . ILE A 1 63 ? -9.043 -34.285 -12.845 1.00 29.33 ? 63 ILE A CG1 1 ATOM 466 C CG2 . ILE A 1 63 ? -6.765 -33.845 -11.972 1.00 24.33 ? 63 ILE A CG2 1 ATOM 467 C CD1 . ILE A 1 63 ? -9.521 -32.864 -13.341 1.00 32.15 ? 63 ILE A CD1 1 ATOM 468 N N . HIS A 1 64 ? -4.870 -33.115 -14.486 1.00 25.06 ? 64 HIS A N 1 ATOM 469 C CA . HIS A 1 64 ? -3.426 -33.127 -14.533 1.00 24.90 ? 64 HIS A CA 1 ATOM 470 C C . HIS A 1 64 ? -2.816 -32.929 -13.132 1.00 24.73 ? 64 HIS A C 1 ATOM 471 O O . HIS A 1 64 ? -3.320 -32.144 -12.368 1.00 25.08 ? 64 HIS A O 1 ATOM 472 C CB . HIS A 1 64 ? -2.977 -32.060 -15.526 1.00 25.11 ? 64 HIS A CB 1 ATOM 473 C CG . HIS A 1 64 ? -1.516 -31.784 -15.500 1.00 25.89 ? 64 HIS A CG 1 ATOM 474 N ND1 . HIS A 1 64 ? -0.570 -32.753 -15.766 1.00 27.27 ? 64 HIS A ND1 1 ATOM 475 C CD2 . HIS A 1 64 ? -0.836 -30.649 -15.220 1.00 24.97 ? 64 HIS A CD2 1 ATOM 476 C CE1 . HIS A 1 64 ? 0.633 -32.228 -15.654 1.00 27.90 ? 64 HIS A CE1 1 ATOM 477 N NE2 . HIS A 1 64 ? 0.497 -30.950 -15.326 1.00 29.79 ? 64 HIS A NE2 1 ATOM 478 N N . TRP A 1 65 ? -1.743 -33.644 -12.806 1.00 24.28 ? 65 TRP A N 1 ATOM 479 C CA . TRP A 1 65 ? -1.048 -33.497 -11.522 1.00 24.59 ? 65 TRP A CA 1 ATOM 480 C C . TRP A 1 65 ? 0.187 -32.686 -11.872 1.00 25.21 ? 65 TRP A C 1 ATOM 481 O O . TRP A 1 65 ? 1.254 -33.248 -12.231 1.00 25.64 ? 65 TRP A O 1 ATOM 482 C CB . TRP A 1 65 ? -0.761 -34.877 -10.911 1.00 23.94 ? 65 TRP A CB 1 ATOM 483 C CG . TRP A 1 65 ? -1.953 -35.748 -11.248 1.00 24.95 ? 65 TRP A CG 1 ATOM 484 C CD1 . TRP A 1 65 ? -2.128 -36.549 -12.382 1.00 23.40 ? 65 TRP A CD1 1 ATOM 485 C CD2 . TRP A 1 65 ? -3.192 -35.805 -10.532 1.00 26.00 ? 65 TRP A CD2 1 ATOM 486 N NE1 . TRP A 1 65 ? -3.390 -37.098 -12.383 1.00 24.48 ? 65 TRP A NE1 1 ATOM 487 C CE2 . TRP A 1 65 ? -4.065 -36.665 -11.263 1.00 26.37 ? 65 TRP A CE2 1 ATOM 488 C CE3 . TRP A 1 65 ? -3.655 -35.229 -9.334 1.00 24.24 ? 65 TRP A CE3 1 ATOM 489 C CZ2 . TRP A 1 65 ? -5.367 -36.945 -10.824 1.00 25.26 ? 65 TRP A CZ2 1 ATOM 490 C CZ3 . TRP A 1 65 ? -4.963 -35.497 -8.917 1.00 22.83 ? 65 TRP A CZ3 1 ATOM 491 C CH2 . TRP A 1 65 ? -5.792 -36.349 -9.647 1.00 23.79 ? 65 TRP A CH2 1 ATOM 492 N N . HIS A 1 66 ? 0.007 -31.360 -11.833 1.00 24.67 ? 66 HIS A N 1 ATOM 493 C CA . HIS A 1 66 ? 1.010 -30.389 -12.234 1.00 24.09 ? 66 HIS A CA 1 ATOM 494 C C . HIS A 1 66 ? 2.296 -30.577 -11.448 1.00 25.01 ? 66 HIS A C 1 ATOM 495 O O . HIS A 1 66 ? 2.290 -30.516 -10.205 1.00 25.32 ? 66 HIS A O 1 ATOM 496 C CB . HIS A 1 66 ? 0.468 -28.988 -11.972 1.00 24.11 ? 66 HIS A CB 1 ATOM 497 C CG . HIS A 1 66 ? 1.277 -27.901 -12.616 1.00 23.42 ? 66 HIS A CG 1 ATOM 498 N ND1 . HIS A 1 66 ? 0.764 -27.064 -13.591 1.00 21.45 ? 66 HIS A ND1 1 ATOM 499 C CD2 . HIS A 1 66 ? 2.567 -27.522 -12.424 1.00 21.12 ? 66 HIS A CD2 1 ATOM 500 C CE1 . HIS A 1 66 ? 1.727 -26.256 -14.003 1.00 23.47 ? 66 HIS A CE1 1 ATOM 501 N NE2 . HIS A 1 66 ? 2.826 -26.511 -13.310 1.00 21.15 ? 66 HIS A NE2 1 ATOM 502 N N . GLY A 1 67 ? 3.408 -30.799 -12.142 1.00 25.39 ? 67 GLY A N 1 ATOM 503 C CA . GLY A 1 67 ? 4.681 -30.999 -11.441 1.00 26.55 ? 67 GLY A CA 1 ATOM 504 C C . GLY A 1 67 ? 5.253 -32.400 -11.402 1.00 27.52 ? 67 GLY A C 1 ATOM 505 O O . GLY A 1 67 ? 6.462 -32.566 -11.359 1.00 28.30 ? 67 GLY A O 1 ATOM 506 N N . PHE A 1 68 ? 4.406 -33.421 -11.420 1.00 28.63 ? 68 PHE A N 1 ATOM 507 C CA . PHE A 1 68 ? 4.887 -34.798 -11.302 1.00 28.73 ? 68 PHE A CA 1 ATOM 508 C C . PHE A 1 68 ? 5.406 -35.232 -12.641 1.00 28.71 ? 68 PHE A C 1 ATOM 509 O O . PHE A 1 68 ? 4.814 -34.911 -13.690 1.00 28.41 ? 68 PHE A O 1 ATOM 510 C CB . PHE A 1 68 ? 3.765 -35.734 -10.901 1.00 29.30 ? 68 PHE A CB 1 ATOM 511 C CG . PHE A 1 68 ? 3.221 -35.500 -9.523 1.00 31.86 ? 68 PHE A CG 1 ATOM 512 C CD1 . PHE A 1 68 ? 3.387 -36.443 -8.532 1.00 34.27 ? 68 PHE A CD1 1 ATOM 513 C CD2 . PHE A 1 68 ? 2.477 -34.368 -9.223 1.00 35.99 ? 68 PHE A CD2 1 ATOM 514 C CE1 . PHE A 1 68 ? 2.865 -36.245 -7.264 1.00 35.01 ? 68 PHE A CE1 1 ATOM 515 C CE2 . PHE A 1 68 ? 1.941 -34.172 -7.938 1.00 35.07 ? 68 PHE A CE2 1 ATOM 516 C CZ . PHE A 1 68 ? 2.151 -35.104 -6.974 1.00 33.97 ? 68 PHE A CZ 1 ATOM 517 N N . PHE A 1 69 ? 6.493 -35.992 -12.609 1.00 28.17 ? 69 PHE A N 1 ATOM 518 C CA . PHE A 1 69 ? 7.116 -36.469 -13.838 1.00 27.79 ? 69 PHE A CA 1 ATOM 519 C C . PHE A 1 69 ? 6.293 -37.548 -14.576 1.00 28.87 ? 69 PHE A C 1 ATOM 520 O O . PHE A 1 69 ? 6.238 -37.562 -15.835 1.00 29.64 ? 69 PHE A O 1 ATOM 521 C CB . PHE A 1 69 ? 8.532 -36.961 -13.554 1.00 27.14 ? 69 PHE A CB 1 ATOM 522 C CG . PHE A 1 69 ? 9.451 -35.907 -12.986 1.00 27.11 ? 69 PHE A CG 1 ATOM 523 C CD1 . PHE A 1 69 ? 9.202 -34.522 -13.205 1.00 28.15 ? 69 PHE A CD1 1 ATOM 524 C CD2 . PHE A 1 69 ? 10.593 -36.285 -12.263 1.00 26.38 ? 69 PHE A CD2 1 ATOM 525 C CE1 . PHE A 1 69 ? 10.050 -33.527 -12.665 1.00 28.21 ? 69 PHE A CE1 1 ATOM 526 C CE2 . PHE A 1 69 ? 11.467 -35.322 -11.736 1.00 28.06 ? 69 PHE A CE2 1 ATOM 527 C CZ . PHE A 1 69 ? 11.205 -33.929 -11.938 1.00 28.29 ? 69 PHE A CZ 1 ATOM 528 N N . GLN A 1 70 ? 5.653 -38.452 -13.825 1.00 28.71 ? 70 GLN A N 1 ATOM 529 C CA . GLN A 1 70 ? 4.869 -39.519 -14.440 1.00 29.07 ? 70 GLN A CA 1 ATOM 530 C C . GLN A 1 70 ? 5.704 -40.405 -15.400 1.00 29.38 ? 70 GLN A C 1 ATOM 531 O O . GLN A 1 70 ? 5.195 -40.901 -16.439 1.00 28.78 ? 70 GLN A O 1 ATOM 532 C CB . GLN A 1 70 ? 3.670 -38.939 -15.204 1.00 29.48 ? 70 GLN A CB 1 ATOM 533 C CG . GLN A 1 70 ? 2.768 -38.043 -14.397 1.00 29.55 ? 70 GLN A CG 1 ATOM 534 C CD . GLN A 1 70 ? 1.637 -38.787 -13.727 1.00 27.70 ? 70 GLN A CD 1 ATOM 535 O OE1 . GLN A 1 70 ? 1.603 -40.026 -13.672 1.00 28.15 ? 70 GLN A OE1 1 ATOM 536 N NE2 . GLN A 1 70 ? 0.700 -38.033 -13.216 1.00 26.68 ? 70 GLN A NE2 1 ATOM 537 N N . HIS A 1 71 ? 6.980 -40.607 -15.071 1.00 29.49 ? 71 HIS A N 1 ATOM 538 C CA . HIS A 1 71 ? 7.745 -41.605 -15.804 1.00 30.33 ? 71 HIS A CA 1 ATOM 539 C C . HIS A 1 71 ? 7.042 -42.964 -15.808 1.00 29.76 ? 71 HIS A C 1 ATOM 540 O O . HIS A 1 71 ? 6.766 -43.538 -14.752 1.00 29.28 ? 71 HIS A O 1 ATOM 541 C CB . HIS A 1 71 ? 9.152 -41.745 -15.245 1.00 31.40 ? 71 HIS A CB 1 ATOM 542 C CG . HIS A 1 71 ? 10.065 -42.548 -16.130 1.00 34.87 ? 71 HIS A CG 1 ATOM 543 N ND1 . HIS A 1 71 ? 10.450 -43.840 -15.828 1.00 36.34 ? 71 HIS A ND1 1 ATOM 544 C CD2 . HIS A 1 71 ? 10.639 -42.254 -17.320 1.00 35.55 ? 71 HIS A CD2 1 ATOM 545 C CE1 . HIS A 1 71 ? 11.233 -44.300 -16.785 1.00 37.05 ? 71 HIS A CE1 1 ATOM 546 N NE2 . HIS A 1 71 ? 11.360 -43.360 -17.705 1.00 37.99 ? 71 HIS A NE2 1 ATOM 547 N N . GLY A 1 72 ? 6.728 -43.458 -17.003 1.00 29.53 ? 72 GLY A N 1 ATOM 548 C CA . GLY A 1 72 ? 6.087 -44.774 -17.148 1.00 28.89 ? 72 GLY A CA 1 ATOM 549 C C . GLY A 1 72 ? 4.573 -44.731 -17.085 1.00 29.02 ? 72 GLY A C 1 ATOM 550 O O . GLY A 1 72 ? 3.912 -45.720 -17.360 1.00 29.33 ? 72 GLY A O 1 ATOM 551 N N . THR A 1 73 ? 4.019 -43.571 -16.736 1.00 28.75 ? 73 THR A N 1 ATOM 552 C CA . THR A 1 73 ? 2.589 -43.390 -16.657 1.00 27.67 ? 73 THR A CA 1 ATOM 553 C C . THR A 1 73 ? 2.196 -42.120 -17.352 1.00 28.28 ? 73 THR A C 1 ATOM 554 O O . THR A 1 73 ? 1.347 -41.377 -16.856 1.00 29.56 ? 73 THR A O 1 ATOM 555 C CB . THR A 1 73 ? 2.097 -43.320 -15.206 1.00 27.17 ? 73 THR A CB 1 ATOM 556 O OG1 . THR A 1 73 ? 2.893 -42.388 -14.475 1.00 25.55 ? 73 THR A OG1 1 ATOM 557 C CG2 . THR A 1 73 ? 2.142 -44.705 -14.540 1.00 26.84 ? 73 THR A CG2 1 ATOM 558 N N . ASN A 1 74 ? 2.801 -41.858 -18.505 1.00 27.67 ? 74 ASN A N 1 ATOM 559 C CA . ASN A 1 74 ? 2.375 -40.767 -19.362 1.00 26.55 ? 74 ASN A CA 1 ATOM 560 C C . ASN A 1 74 ? 0.858 -40.750 -19.588 1.00 26.34 ? 74 ASN A C 1 ATOM 561 O O . ASN A 1 74 ? 0.264 -39.688 -19.832 1.00 26.50 ? 74 ASN A O 1 ATOM 562 C CB . ASN A 1 74 ? 3.103 -40.906 -20.676 1.00 26.65 ? 74 ASN A CB 1 ATOM 563 C CG . ASN A 1 74 ? 2.767 -39.821 -21.643 1.00 27.97 ? 74 ASN A CG 1 ATOM 564 O OD1 . ASN A 1 74 ? 1.795 -39.922 -22.406 1.00 25.98 ? 74 ASN A OD1 1 ATOM 565 N ND2 . ASN A 1 74 ? 3.584 -38.766 -21.645 1.00 29.84 ? 74 ASN A ND2 1 ATOM 566 N N . TRP A 1 75 ? 0.210 -41.914 -19.506 1.00 25.96 ? 75 TRP A N 1 ATOM 567 C CA . TRP A 1 75 ? -1.245 -41.977 -19.793 1.00 26.42 ? 75 TRP A CA 1 ATOM 568 C C . TRP A 1 75 ? -2.055 -41.243 -18.711 1.00 26.56 ? 75 TRP A C 1 ATOM 569 O O . TRP A 1 75 ? -3.222 -40.867 -18.935 1.00 26.09 ? 75 TRP A O 1 ATOM 570 C CB . TRP A 1 75 ? -1.736 -43.415 -19.936 1.00 25.83 ? 75 TRP A CB 1 ATOM 571 C CG . TRP A 1 75 ? -1.343 -44.209 -18.758 1.00 27.57 ? 75 TRP A CG 1 ATOM 572 C CD1 . TRP A 1 75 ? -0.185 -44.956 -18.613 1.00 27.99 ? 75 TRP A CD1 1 ATOM 573 C CD2 . TRP A 1 75 ? -2.038 -44.300 -17.503 1.00 27.53 ? 75 TRP A CD2 1 ATOM 574 N NE1 . TRP A 1 75 ? -0.151 -45.527 -17.355 1.00 28.73 ? 75 TRP A NE1 1 ATOM 575 C CE2 . TRP A 1 75 ? -1.270 -45.144 -16.656 1.00 28.05 ? 75 TRP A CE2 1 ATOM 576 C CE3 . TRP A 1 75 ? -3.252 -43.790 -17.022 1.00 29.19 ? 75 TRP A CE3 1 ATOM 577 C CZ2 . TRP A 1 75 ? -1.673 -45.471 -15.353 1.00 26.55 ? 75 TRP A CZ2 1 ATOM 578 C CZ3 . TRP A 1 75 ? -3.660 -44.147 -15.711 1.00 27.07 ? 75 TRP A CZ3 1 ATOM 579 C CH2 . TRP A 1 75 ? -2.870 -44.972 -14.911 1.00 26.08 ? 75 TRP A CH2 1 ATOM 580 N N . ALA A 1 76 ? -1.422 -41.044 -17.551 1.00 25.98 ? 76 ALA A N 1 ATOM 581 C CA . ALA A 1 76 ? -2.094 -40.464 -16.414 1.00 25.95 ? 76 ALA A CA 1 ATOM 582 C C . ALA A 1 76 ? -1.796 -38.968 -16.267 1.00 25.95 ? 76 ALA A C 1 ATOM 583 O O . ALA A 1 76 ? -2.193 -38.331 -15.282 1.00 27.04 ? 76 ALA A O 1 ATOM 584 C CB . ALA A 1 76 ? -1.723 -41.229 -15.154 1.00 25.48 ? 76 ALA A CB 1 ATOM 585 N N . ASP A 1 77 ? -1.101 -38.407 -17.242 1.00 25.00 ? 77 ASP A N 1 ATOM 586 C CA . ASP A 1 77 ? -0.679 -37.010 -17.156 1.00 24.47 ? 77 ASP A CA 1 ATOM 587 C C . ASP A 1 77 ? -1.826 -36.005 -17.144 1.00 24.26 ? 77 ASP A C 1 ATOM 588 O O . ASP A 1 77 ? -1.741 -35.044 -16.407 1.00 24.66 ? 77 ASP A O 1 ATOM 589 C CB . ASP A 1 77 ? 0.354 -36.648 -18.250 1.00 24.47 ? 77 ASP A CB 1 ATOM 590 C CG . ASP A 1 77 ? 1.071 -35.336 -17.970 1.00 23.30 ? 77 ASP A CG 1 ATOM 591 O OD1 . ASP A 1 77 ? 1.365 -35.011 -16.785 1.00 21.11 ? 77 ASP A OD1 1 ATOM 592 O OD2 . ASP A 1 77 ? 1.336 -34.618 -18.959 1.00 23.04 ? 77 ASP A OD2 1 ATOM 593 N N . GLY A 1 78 ? -2.861 -36.191 -17.973 1.00 23.64 ? 78 GLY A N 1 ATOM 594 C CA . GLY A 1 78 ? -4.043 -35.365 -17.883 1.00 22.53 ? 78 GLY A CA 1 ATOM 595 C C . GLY A 1 78 ? -4.479 -34.563 -19.091 1.00 23.46 ? 78 GLY A C 1 ATOM 596 O O . GLY A 1 78 ? -5.653 -34.590 -19.422 1.00 23.73 ? 78 GLY A O 1 ATOM 597 N N . PRO A 1 79 ? -3.567 -33.810 -19.757 1.00 23.29 ? 79 PRO A N 1 ATOM 598 C CA . PRO A 1 79 ? -4.011 -32.963 -20.848 1.00 23.02 ? 79 PRO A CA 1 ATOM 599 C C . PRO A 1 79 ? -4.958 -33.661 -21.785 1.00 24.28 ? 79 PRO A C 1 ATOM 600 O O . PRO A 1 79 ? -4.619 -34.705 -22.329 1.00 25.06 ? 79 PRO A O 1 ATOM 601 C CB . PRO A 1 79 ? -2.725 -32.654 -21.592 1.00 22.68 ? 79 PRO A CB 1 ATOM 602 C CG . PRO A 1 79 ? -1.759 -32.597 -20.571 1.00 23.78 ? 79 PRO A CG 1 ATOM 603 C CD . PRO A 1 79 ? -2.118 -33.697 -19.568 1.00 22.88 ? 79 PRO A CD 1 ATOM 604 N N . ALA A 1 80 ? -6.146 -33.083 -21.986 1.00 25.56 ? 80 ALA A N 1 ATOM 605 C CA . ALA A 1 80 ? -7.155 -33.668 -22.871 1.00 25.76 ? 80 ALA A CA 1 ATOM 606 C C . ALA A 1 80 ? -6.641 -33.667 -24.326 1.00 26.83 ? 80 ALA A C 1 ATOM 607 O O . ALA A 1 80 ? -6.219 -32.624 -24.850 1.00 27.79 ? 80 ALA A O 1 ATOM 608 C CB . ALA A 1 80 ? -8.433 -32.924 -22.748 1.00 24.74 ? 80 ALA A CB 1 ATOM 609 N N . PHE A 1 81 ? -6.658 -34.847 -24.950 1.00 26.84 ? 81 PHE A N 1 ATOM 610 C CA . PHE A 1 81 ? -6.239 -35.046 -26.343 1.00 26.47 ? 81 PHE A CA 1 ATOM 611 C C . PHE A 1 81 ? -4.742 -35.015 -26.577 1.00 25.88 ? 81 PHE A C 1 ATOM 612 O O . PHE A 1 81 ? -4.295 -35.058 -27.730 1.00 24.93 ? 81 PHE A O 1 ATOM 613 C CB . PHE A 1 81 ? -6.934 -34.080 -27.297 1.00 27.20 ? 81 PHE A CB 1 ATOM 614 C CG . PHE A 1 81 ? -8.411 -34.015 -27.112 1.00 28.58 ? 81 PHE A CG 1 ATOM 615 C CD1 . PHE A 1 81 ? -9.217 -35.011 -27.599 1.00 29.84 ? 81 PHE A CD1 1 ATOM 616 C CD2 . PHE A 1 81 ? -8.990 -32.941 -26.435 1.00 30.45 ? 81 PHE A CD2 1 ATOM 617 C CE1 . PHE A 1 81 ? -10.579 -34.948 -27.407 1.00 32.66 ? 81 PHE A CE1 1 ATOM 618 C CE2 . PHE A 1 81 ? -10.348 -32.857 -26.255 1.00 30.39 ? 81 PHE A CE2 1 ATOM 619 C CZ . PHE A 1 81 ? -11.146 -33.848 -26.744 1.00 30.68 ? 81 PHE A CZ 1 ATOM 620 N N . VAL A 1 82 ? -3.957 -34.934 -25.502 1.00 25.73 ? 82 VAL A N 1 ATOM 621 C CA . VAL A 1 82 ? -2.524 -35.177 -25.638 1.00 25.49 ? 82 VAL A CA 1 ATOM 622 C C . VAL A 1 82 ? -2.289 -36.508 -24.941 1.00 26.19 ? 82 VAL A C 1 ATOM 623 O O . VAL A 1 82 ? -1.673 -37.421 -25.485 1.00 26.84 ? 82 VAL A O 1 ATOM 624 C CB . VAL A 1 82 ? -1.637 -34.047 -25.027 1.00 25.50 ? 82 VAL A CB 1 ATOM 625 C CG1 . VAL A 1 82 ? -0.159 -34.370 -25.193 1.00 23.81 ? 82 VAL A CG1 1 ATOM 626 C CG2 . VAL A 1 82 ? -1.936 -32.685 -25.662 1.00 24.94 ? 82 VAL A CG2 1 ATOM 627 N N . ASN A 1 83 ? -2.836 -36.634 -23.745 1.00 26.16 ? 83 ASN A N 1 ATOM 628 C CA . ASN A 1 83 ? -2.528 -37.769 -22.931 1.00 26.08 ? 83 ASN A CA 1 ATOM 629 C C . ASN A 1 83 ? -3.718 -38.715 -22.650 1.00 25.93 ? 83 ASN A C 1 ATOM 630 O O . ASN A 1 83 ? -3.527 -39.903 -22.415 1.00 26.50 ? 83 ASN A O 1 ATOM 631 C CB . ASN A 1 83 ? -1.781 -37.287 -21.714 1.00 26.02 ? 83 ASN A CB 1 ATOM 632 C CG . ASN A 1 83 ? -0.578 -36.446 -22.093 1.00 27.06 ? 83 ASN A CG 1 ATOM 633 O OD1 . ASN A 1 83 ? -0.655 -35.222 -22.122 1.00 26.79 ? 83 ASN A OD1 1 ATOM 634 N ND2 . ASN A 1 83 ? 0.540 -37.104 -22.423 1.00 27.89 ? 83 ASN A ND2 1 ATOM 635 N N . GLN A 1 84 ? -4.936 -38.213 -22.762 1.00 25.84 ? 84 GLN A N 1 ATOM 636 C CA . GLN A 1 84 ? -6.139 -39.072 -22.724 1.00 25.90 ? 84 GLN A CA 1 ATOM 637 C C . GLN A 1 84 ? -7.282 -38.413 -23.510 1.00 26.23 ? 84 GLN A C 1 ATOM 638 O O . GLN A 1 84 ? -7.212 -37.207 -23.807 1.00 26.35 ? 84 GLN A O 1 ATOM 639 C CB . GLN A 1 84 ? -6.595 -39.307 -21.271 1.00 25.29 ? 84 GLN A CB 1 ATOM 640 C CG . GLN A 1 84 ? -6.923 -38.000 -20.565 1.00 24.50 ? 84 GLN A CG 1 ATOM 641 C CD . GLN A 1 84 ? -7.475 -38.171 -19.168 1.00 24.75 ? 84 GLN A CD 1 ATOM 642 O OE1 . GLN A 1 84 ? -6.734 -38.081 -18.185 1.00 23.79 ? 84 GLN A OE1 1 ATOM 643 N NE2 . GLN A 1 84 ? -8.778 -38.421 -19.067 1.00 19.88 ? 84 GLN A NE2 1 ATOM 644 N N . CYS A 1 85 ? -8.329 -39.182 -23.835 1.00 26.75 ? 85 CYS A N 1 ATOM 645 C CA . CYS A 1 85 ? -9.678 -38.562 -24.014 1.00 27.34 ? 85 CYS A CA 1 ATOM 646 C C . CYS A 1 85 ? -10.242 -38.163 -22.652 1.00 27.02 ? 85 CYS A C 1 ATOM 647 O O . CYS A 1 85 ? -9.908 -38.763 -21.632 1.00 26.55 ? 85 CYS A O 1 ATOM 648 C CB . CYS A 1 85 ? -10.672 -39.473 -24.739 1.00 27.10 ? 85 CYS A CB 1 ATOM 649 S SG . CYS A 1 85 ? -10.321 -39.688 -26.498 1.00 28.40 ? 85 CYS A SG 1 ATOM 650 N N . PRO A 1 86 ? -11.106 -37.150 -22.624 1.00 27.34 ? 86 PRO A N 1 ATOM 651 C CA . PRO A 1 86 ? -11.578 -36.805 -21.280 1.00 26.92 ? 86 PRO A CA 1 ATOM 652 C C . PRO A 1 86 ? -12.403 -37.921 -20.628 1.00 26.52 ? 86 PRO A C 1 ATOM 653 O O . PRO A 1 86 ? -13.010 -38.720 -21.329 1.00 25.82 ? 86 PRO A O 1 ATOM 654 C CB . PRO A 1 86 ? -12.437 -35.533 -21.504 1.00 26.74 ? 86 PRO A CB 1 ATOM 655 C CG . PRO A 1 86 ? -12.164 -35.051 -22.915 1.00 26.71 ? 86 PRO A CG 1 ATOM 656 C CD . PRO A 1 86 ? -11.711 -36.298 -23.680 1.00 27.78 ? 86 PRO A CD 1 ATOM 657 N N . ILE A 1 87 ? -12.397 -37.976 -19.294 1.00 26.62 ? 87 ILE A N 1 ATOM 658 C CA . ILE A 1 87 ? -13.363 -38.779 -18.564 1.00 27.53 ? 87 ILE A CA 1 ATOM 659 C C . ILE A 1 87 ? -14.774 -38.324 -18.932 1.00 28.56 ? 87 ILE A C 1 ATOM 660 O O . ILE A 1 87 ? -15.038 -37.114 -19.019 1.00 28.92 ? 87 ILE A O 1 ATOM 661 C CB . ILE A 1 87 ? -13.211 -38.632 -17.047 1.00 27.58 ? 87 ILE A CB 1 ATOM 662 C CG1 . ILE A 1 87 ? -11.724 -38.519 -16.650 1.00 27.73 ? 87 ILE A CG1 1 ATOM 663 C CG2 . ILE A 1 87 ? -13.992 -39.732 -16.320 1.00 26.14 ? 87 ILE A CG2 1 ATOM 664 C CD1 . ILE A 1 87 ? -11.418 -38.874 -15.218 1.00 24.65 ? 87 ILE A CD1 1 ATOM 665 N N . SER A 1 88 ? -15.676 -39.286 -19.129 1.00 29.29 ? 88 SER A N 1 ATOM 666 C CA . SER A 1 88 ? -17.054 -38.986 -19.476 1.00 30.35 ? 88 SER A CA 1 ATOM 667 C C . SER A 1 88 ? -17.956 -38.989 -18.247 1.00 31.23 ? 88 SER A C 1 ATOM 668 O O . SER A 1 88 ? -17.709 -39.710 -17.274 1.00 31.81 ? 88 SER A O 1 ATOM 669 C CB . SER A 1 88 ? -17.569 -39.972 -20.520 1.00 30.38 ? 88 SER A CB 1 ATOM 670 O OG . SER A 1 88 ? -17.029 -39.686 -21.800 1.00 31.97 ? 88 SER A OG 1 ATOM 671 N N . THR A 1 89 ? -19.005 -38.174 -18.295 1.00 32.11 ? 89 THR A N 1 ATOM 672 C CA . THR A 1 89 ? -19.859 -37.962 -17.134 1.00 32.44 ? 89 THR A CA 1 ATOM 673 C C . THR A 1 89 ? -20.666 -39.199 -16.851 1.00 32.27 ? 89 THR A C 1 ATOM 674 O O . THR A 1 89 ? -21.212 -39.814 -17.755 1.00 31.90 ? 89 THR A O 1 ATOM 675 C CB . THR A 1 89 ? -20.769 -36.678 -17.259 1.00 32.72 ? 89 THR A CB 1 ATOM 676 O OG1 . THR A 1 89 ? -21.488 -36.483 -16.035 1.00 33.58 ? 89 THR A OG1 1 ATOM 677 C CG2 . THR A 1 89 ? -21.778 -36.790 -18.410 1.00 32.52 ? 89 THR A CG2 1 ATOM 678 N N . GLY A 1 90 ? -20.734 -39.544 -15.579 1.00 32.60 ? 90 GLY A N 1 ATOM 679 C CA . GLY A 1 90 ? -21.319 -40.799 -15.152 1.00 33.21 ? 90 GLY A CA 1 ATOM 680 C C . GLY A 1 90 ? -20.323 -41.936 -15.124 1.00 33.90 ? 90 GLY A C 1 ATOM 681 O O . GLY A 1 90 ? -20.697 -43.060 -14.871 1.00 35.04 ? 90 GLY A O 1 ATOM 682 N N . HIS A 1 91 ? -19.046 -41.650 -15.374 1.00 34.41 ? 91 HIS A N 1 ATOM 683 C CA . HIS A 1 91 ? -17.989 -42.668 -15.352 1.00 33.65 ? 91 HIS A CA 1 ATOM 684 C C . HIS A 1 91 ? -16.918 -42.294 -14.344 1.00 33.62 ? 91 HIS A C 1 ATOM 685 O O . HIS A 1 91 ? -16.834 -41.131 -13.935 1.00 34.14 ? 91 HIS A O 1 ATOM 686 C CB . HIS A 1 91 ? -17.376 -42.824 -16.743 1.00 33.36 ? 91 HIS A CB 1 ATOM 687 C CG . HIS A 1 91 ? -18.361 -43.277 -17.766 1.00 34.09 ? 91 HIS A CG 1 ATOM 688 N ND1 . HIS A 1 91 ? -18.353 -44.549 -18.288 1.00 33.65 ? 91 HIS A ND1 1 ATOM 689 C CD2 . HIS A 1 91 ? -19.427 -42.649 -18.321 1.00 33.41 ? 91 HIS A CD2 1 ATOM 690 C CE1 . HIS A 1 91 ? -19.359 -44.680 -19.135 1.00 32.53 ? 91 HIS A CE1 1 ATOM 691 N NE2 . HIS A 1 91 ? -20.020 -43.540 -19.180 1.00 31.38 ? 91 HIS A NE2 1 ATOM 692 N N . ALA A 1 92 ? -16.118 -43.282 -13.934 1.00 32.65 ? 92 ALA A N 1 ATOM 693 C CA . ALA A 1 92 ? -14.935 -43.049 -13.121 1.00 31.27 ? 92 ALA A CA 1 ATOM 694 C C . ALA A 1 92 ? -13.672 -43.418 -13.904 1.00 31.10 ? 92 ALA A C 1 ATOM 695 O O . ALA A 1 92 ? -13.751 -44.081 -14.957 1.00 30.45 ? 92 ALA A O 1 ATOM 696 C CB . ALA A 1 92 ? -15.022 -43.839 -11.904 1.00 31.28 ? 92 ALA A CB 1 ATOM 697 N N . PHE A 1 93 ? -12.518 -42.958 -13.409 1.00 30.03 ? 93 PHE A N 1 ATOM 698 C CA . PHE A 1 93 ? -11.232 -43.249 -14.028 1.00 29.67 ? 93 PHE A CA 1 ATOM 699 C C . PHE A 1 93 ? -10.114 -43.064 -13.032 1.00 29.75 ? 93 PHE A C 1 ATOM 700 O O . PHE A 1 93 ? -9.988 -42.006 -12.462 1.00 30.79 ? 93 PHE A O 1 ATOM 701 C CB . PHE A 1 93 ? -10.960 -42.350 -15.222 1.00 29.72 ? 93 PHE A CB 1 ATOM 702 C CG . PHE A 1 93 ? -9.605 -42.561 -15.815 1.00 30.68 ? 93 PHE A CG 1 ATOM 703 C CD1 . PHE A 1 93 ? -9.284 -43.790 -16.429 1.00 31.13 ? 93 PHE A CD1 1 ATOM 704 C CD2 . PHE A 1 93 ? -8.633 -41.559 -15.748 1.00 29.63 ? 93 PHE A CD2 1 ATOM 705 C CE1 . PHE A 1 93 ? -8.011 -44.015 -16.983 1.00 29.74 ? 93 PHE A CE1 1 ATOM 706 C CE2 . PHE A 1 93 ? -7.362 -41.767 -16.288 1.00 30.80 ? 93 PHE A CE2 1 ATOM 707 C CZ . PHE A 1 93 ? -7.046 -43.003 -16.904 1.00 31.37 ? 93 PHE A CZ 1 ATOM 708 N N . LEU A 1 94 ? -9.296 -44.089 -12.833 1.00 29.65 ? 94 LEU A N 1 ATOM 709 C CA . LEU A 1 94 ? -8.307 -44.090 -11.777 1.00 29.22 ? 94 LEU A CA 1 ATOM 710 C C . LEU A 1 94 ? -6.922 -43.676 -12.311 1.00 29.27 ? 94 LEU A C 1 ATOM 711 O O . LEU A 1 94 ? -6.352 -44.314 -13.223 1.00 28.84 ? 94 LEU A O 1 ATOM 712 C CB . LEU A 1 94 ? -8.253 -45.471 -11.125 1.00 29.22 ? 94 LEU A CB 1 ATOM 713 C CG . LEU A 1 94 ? -7.130 -45.730 -10.108 1.00 30.15 ? 94 LEU A CG 1 ATOM 714 C CD1 . LEU A 1 94 ? -7.225 -44.741 -8.934 1.00 30.13 ? 94 LEU A CD1 1 ATOM 715 C CD2 . LEU A 1 94 ? -7.162 -47.178 -9.597 1.00 29.02 ? 94 LEU A CD2 1 ATOM 716 N N . TYR A 1 95 ? -6.405 -42.586 -11.757 1.00 28.51 ? 95 TYR A N 1 ATOM 717 C CA . TYR A 1 95 ? -5.060 -42.164 -12.046 1.00 28.30 ? 95 TYR A CA 1 ATOM 718 C C . TYR A 1 95 ? -4.235 -42.846 -10.978 1.00 29.23 ? 95 TYR A C 1 ATOM 719 O O . TYR A 1 95 ? -4.368 -42.559 -9.792 1.00 30.02 ? 95 TYR A O 1 ATOM 720 C CB . TYR A 1 95 ? -4.935 -40.649 -11.979 1.00 27.12 ? 95 TYR A CB 1 ATOM 721 C CG . TYR A 1 95 ? -5.710 -39.892 -13.047 1.00 24.74 ? 95 TYR A CG 1 ATOM 722 C CD1 . TYR A 1 95 ? -7.053 -39.560 -12.848 1.00 23.03 ? 95 TYR A CD1 1 ATOM 723 C CD2 . TYR A 1 95 ? -5.095 -39.493 -14.242 1.00 22.20 ? 95 TYR A CD2 1 ATOM 724 C CE1 . TYR A 1 95 ? -7.781 -38.844 -13.809 1.00 24.10 ? 95 TYR A CE1 1 ATOM 725 C CE2 . TYR A 1 95 ? -5.802 -38.781 -15.220 1.00 23.94 ? 95 TYR A CE2 1 ATOM 726 C CZ . TYR A 1 95 ? -7.159 -38.455 -14.997 1.00 25.43 ? 95 TYR A CZ 1 ATOM 727 O OH . TYR A 1 95 ? -7.899 -37.759 -15.937 1.00 23.18 ? 95 TYR A OH 1 ATOM 728 N N . ASP A 1 96 ? -3.433 -43.806 -11.416 1.00 30.12 ? 96 ASP A N 1 ATOM 729 C CA . ASP A 1 96 ? -2.579 -44.622 -10.564 1.00 30.45 ? 96 ASP A CA 1 ATOM 730 C C . ASP A 1 96 ? -1.120 -44.358 -10.911 1.00 30.49 ? 96 ASP A C 1 ATOM 731 O O . ASP A 1 96 ? -0.644 -44.786 -11.965 1.00 30.35 ? 96 ASP A O 1 ATOM 732 C CB . ASP A 1 96 ? -2.881 -46.059 -10.896 1.00 31.06 ? 96 ASP A CB 1 ATOM 733 C CG . ASP A 1 96 ? -2.381 -47.031 -9.854 1.00 32.67 ? 96 ASP A CG 1 ATOM 734 O OD1 . ASP A 1 96 ? -3.026 -48.099 -9.767 1.00 34.71 ? 96 ASP A OD1 1 ATOM 735 O OD2 . ASP A 1 96 ? -1.357 -46.762 -9.174 1.00 33.07 ? 96 ASP A OD2 1 ATOM 736 N N . PHE A 1 97 ? -0.407 -43.648 -10.051 1.00 30.38 ? 97 PHE A N 1 ATOM 737 C CA . PHE A 1 97 ? 0.976 -43.324 -10.364 1.00 30.67 ? 97 PHE A CA 1 ATOM 738 C C . PHE A 1 97 ? 1.859 -43.222 -9.117 1.00 30.95 ? 97 PHE A C 1 ATOM 739 O O . PHE A 1 97 ? 1.377 -43.204 -8.006 1.00 30.26 ? 97 PHE A O 1 ATOM 740 C CB . PHE A 1 97 ? 1.045 -42.056 -11.245 1.00 30.30 ? 97 PHE A CB 1 ATOM 741 C CG . PHE A 1 97 ? 0.497 -40.809 -10.581 1.00 30.00 ? 97 PHE A CG 1 ATOM 742 C CD1 . PHE A 1 97 ? 1.312 -40.006 -9.790 1.00 29.51 ? 97 PHE A CD1 1 ATOM 743 C CD2 . PHE A 1 97 ? -0.834 -40.442 -10.734 1.00 29.48 ? 97 PHE A CD2 1 ATOM 744 C CE1 . PHE A 1 97 ? 0.818 -38.865 -9.176 1.00 28.19 ? 97 PHE A CE1 1 ATOM 745 C CE2 . PHE A 1 97 ? -1.319 -39.273 -10.130 1.00 29.52 ? 97 PHE A CE2 1 ATOM 746 C CZ . PHE A 1 97 ? -0.497 -38.500 -9.364 1.00 29.14 ? 97 PHE A CZ 1 ATOM 747 N N . GLN A 1 98 ? 3.166 -43.173 -9.324 1.00 32.70 ? 98 GLN A N 1 ATOM 748 C CA . GLN A 1 98 ? 4.127 -43.021 -8.221 1.00 33.81 ? 98 GLN A CA 1 ATOM 749 C C . GLN A 1 98 ? 4.966 -41.763 -8.332 1.00 33.69 ? 98 GLN A C 1 ATOM 750 O O . GLN A 1 98 ? 5.193 -41.241 -9.428 1.00 33.74 ? 98 GLN A O 1 ATOM 751 C CB . GLN A 1 98 ? 5.079 -44.194 -8.182 1.00 33.96 ? 98 GLN A CB 1 ATOM 752 C CG . GLN A 1 98 ? 4.442 -45.464 -8.562 1.00 36.30 ? 98 GLN A CG 1 ATOM 753 C CD . GLN A 1 98 ? 5.186 -46.606 -7.981 1.00 40.74 ? 98 GLN A CD 1 ATOM 754 O OE1 . GLN A 1 98 ? 5.312 -46.719 -6.753 1.00 41.75 ? 98 GLN A OE1 1 ATOM 755 N NE2 . GLN A 1 98 ? 5.718 -47.462 -8.845 1.00 40.98 ? 98 GLN A NE2 1 ATOM 756 N N . VAL A 1 99 ? 5.427 -41.293 -7.187 1.00 33.64 ? 99 VAL A N 1 ATOM 757 C CA . VAL A 1 99 ? 6.392 -40.235 -7.185 1.00 34.35 ? 99 VAL A CA 1 ATOM 758 C C . VAL A 1 99 ? 7.667 -40.677 -6.477 1.00 34.72 ? 99 VAL A C 1 ATOM 759 O O . VAL A 1 99 ? 7.930 -40.247 -5.359 1.00 35.15 ? 99 VAL A O 1 ATOM 760 C CB . VAL A 1 99 ? 5.813 -38.912 -6.613 1.00 34.57 ? 99 VAL A CB 1 ATOM 761 C CG1 . VAL A 1 99 ? 4.679 -38.502 -7.449 1.00 35.15 ? 99 VAL A CG1 1 ATOM 762 C CG2 . VAL A 1 99 ? 5.324 -39.059 -5.192 1.00 33.30 ? 99 VAL A CG2 1 ATOM 763 N N . PRO A 1 100 ? 8.488 -41.534 -7.127 1.00 35.21 ? 100 PRO A N 1 ATOM 764 C CA . PRO A 1 100 ? 9.778 -41.737 -6.424 1.00 35.72 ? 100 PRO A CA 1 ATOM 765 C C . PRO A 1 100 ? 10.528 -40.417 -6.688 1.00 36.25 ? 100 PRO A C 1 ATOM 766 O O . PRO A 1 100 ? 9.997 -39.555 -7.396 1.00 37.30 ? 100 PRO A O 1 ATOM 767 C CB . PRO A 1 100 ? 10.396 -42.906 -7.178 1.00 35.59 ? 100 PRO A CB 1 ATOM 768 C CG . PRO A 1 100 ? 9.823 -42.728 -8.639 1.00 34.40 ? 100 PRO A CG 1 ATOM 769 C CD . PRO A 1 100 ? 8.427 -42.227 -8.439 1.00 34.51 ? 100 PRO A CD 1 ATOM 770 N N . ASP A 1 101 ? 11.700 -40.194 -6.138 1.00 36.21 ? 101 ASP A N 1 ATOM 771 C CA . ASP A 1 101 ? 12.502 -39.040 -6.616 1.00 36.25 ? 101 ASP A CA 1 ATOM 772 C C . ASP A 1 101 ? 11.888 -37.615 -6.621 1.00 35.38 ? 101 ASP A C 1 ATOM 773 O O . ASP A 1 101 ? 12.605 -36.659 -6.983 1.00 36.43 ? 101 ASP A O 1 ATOM 774 C CB . ASP A 1 101 ? 13.213 -39.331 -7.974 1.00 36.93 ? 101 ASP A CB 1 ATOM 775 C CG . ASP A 1 101 ? 12.255 -39.301 -9.244 1.00 40.13 ? 101 ASP A CG 1 ATOM 776 O OD1 . ASP A 1 101 ? 12.775 -39.496 -10.372 1.00 42.47 ? 101 ASP A OD1 1 ATOM 777 O OD2 . ASP A 1 101 ? 11.015 -39.092 -9.166 1.00 42.26 ? 101 ASP A OD2 1 ATOM 778 N N . GLN A 1 102 ? 10.614 -37.436 -6.251 1.00 33.29 ? 102 GLN A N 1 ATOM 779 C CA . GLN A 1 102 ? 10.088 -36.055 -6.061 1.00 32.05 ? 102 GLN A CA 1 ATOM 780 C C . GLN A 1 102 ? 9.481 -35.822 -4.677 1.00 30.83 ? 102 GLN A C 1 ATOM 781 O O . GLN A 1 102 ? 8.984 -36.730 -4.042 1.00 31.52 ? 102 GLN A O 1 ATOM 782 C CB . GLN A 1 102 ? 9.093 -35.637 -7.133 1.00 31.17 ? 102 GLN A CB 1 ATOM 783 C CG . GLN A 1 102 ? 9.620 -35.675 -8.505 1.00 32.47 ? 102 GLN A CG 1 ATOM 784 C CD . GLN A 1 102 ? 8.665 -35.077 -9.503 1.00 35.03 ? 102 GLN A CD 1 ATOM 785 O OE1 . GLN A 1 102 ? 7.879 -35.788 -10.148 1.00 36.74 ? 102 GLN A OE1 1 ATOM 786 N NE2 . GLN A 1 102 ? 8.714 -33.757 -9.637 1.00 34.62 ? 102 GLN A NE2 1 ATOM 787 N N . ALA A 1 103 ? 9.545 -34.596 -4.212 1.00 29.12 ? 103 ALA A N 1 ATOM 788 C CA . ALA A 1 103 ? 8.780 -34.180 -3.051 1.00 28.08 ? 103 ALA A CA 1 ATOM 789 C C . ALA A 1 103 ? 8.717 -32.659 -3.102 1.00 26.94 ? 103 ALA A C 1 ATOM 790 O O . ALA A 1 103 ? 9.599 -32.014 -3.620 1.00 25.75 ? 103 ALA A O 1 ATOM 791 C CB . ALA A 1 103 ? 9.445 -34.660 -1.763 1.00 28.42 ? 103 ALA A CB 1 ATOM 792 N N . GLY A 1 104 ? 7.656 -32.081 -2.588 1.00 27.12 ? 104 GLY A N 1 ATOM 793 C CA . GLY A 1 104 ? 7.544 -30.623 -2.651 1.00 26.75 ? 104 GLY A CA 1 ATOM 794 C C . GLY A 1 104 ? 6.118 -30.154 -2.743 1.00 26.06 ? 104 GLY A C 1 ATOM 795 O O . GLY A 1 104 ? 5.198 -30.829 -2.260 1.00 26.53 ? 104 GLY A O 1 ATOM 796 N N . THR A 1 105 ? 5.962 -28.996 -3.363 1.00 25.29 ? 105 THR A N 1 ATOM 797 C CA . THR A 1 105 ? 4.690 -28.384 -3.554 1.00 25.09 ? 105 THR A CA 1 ATOM 798 C C . THR A 1 105 ? 4.239 -28.481 -5.021 1.00 25.61 ? 105 THR A C 1 ATOM 799 O O . THR A 1 105 ? 4.962 -28.139 -5.973 1.00 26.29 ? 105 THR A O 1 ATOM 800 C CB . THR A 1 105 ? 4.665 -26.946 -2.986 1.00 25.15 ? 105 THR A CB 1 ATOM 801 O OG1 . THR A 1 105 ? 5.351 -26.948 -1.746 1.00 24.30 ? 105 THR A OG1 1 ATOM 802 C CG2 . THR A 1 105 ? 3.202 -26.473 -2.701 1.00 23.47 ? 105 THR A CG2 1 ATOM 803 N N . PHE A 1 106 ? 3.015 -28.957 -5.157 1.00 24.78 ? 106 PHE A N 1 ATOM 804 C CA . PHE A 1 106 ? 2.443 -29.360 -6.402 1.00 24.82 ? 106 PHE A CA 1 ATOM 805 C C . PHE A 1 106 ? 0.993 -28.862 -6.381 1.00 24.24 ? 106 PHE A C 1 ATOM 806 O O . PHE A 1 106 ? 0.521 -28.310 -5.358 1.00 24.03 ? 106 PHE A O 1 ATOM 807 C CB . PHE A 1 106 ? 2.417 -30.908 -6.466 1.00 25.61 ? 106 PHE A CB 1 ATOM 808 C CG . PHE A 1 106 ? 3.789 -31.578 -6.544 1.00 25.61 ? 106 PHE A CG 1 ATOM 809 C CD1 . PHE A 1 106 ? 4.359 -31.899 -7.787 1.00 26.95 ? 106 PHE A CD1 1 ATOM 810 C CD2 . PHE A 1 106 ? 4.482 -31.931 -5.378 1.00 25.53 ? 106 PHE A CD2 1 ATOM 811 C CE1 . PHE A 1 106 ? 5.632 -32.529 -7.868 1.00 27.57 ? 106 PHE A CE1 1 ATOM 812 C CE2 . PHE A 1 106 ? 5.746 -32.565 -5.433 1.00 25.01 ? 106 PHE A CE2 1 ATOM 813 C CZ . PHE A 1 106 ? 6.329 -32.856 -6.679 1.00 26.16 ? 106 PHE A CZ 1 ATOM 814 N N . TRP A 1 107 ? 0.285 -29.056 -7.492 1.00 22.95 ? 107 TRP A N 1 ATOM 815 C CA . TRP A 1 107 ? -1.155 -28.847 -7.525 1.00 22.56 ? 107 TRP A CA 1 ATOM 816 C C . TRP A 1 107 ? -1.807 -29.629 -8.646 1.00 22.57 ? 107 TRP A C 1 ATOM 817 O O . TRP A 1 107 ? -1.117 -30.123 -9.525 1.00 23.68 ? 107 TRP A O 1 ATOM 818 C CB . TRP A 1 107 ? -1.480 -27.358 -7.597 1.00 22.26 ? 107 TRP A CB 1 ATOM 819 C CG . TRP A 1 107 ? -1.162 -26.629 -8.892 1.00 22.07 ? 107 TRP A CG 1 ATOM 820 C CD1 . TRP A 1 107 ? 0.069 -26.445 -9.457 1.00 21.79 ? 107 TRP A CD1 1 ATOM 821 C CD2 . TRP A 1 107 ? -2.093 -25.931 -9.737 1.00 21.92 ? 107 TRP A CD2 1 ATOM 822 N NE1 . TRP A 1 107 ? -0.040 -25.707 -10.618 1.00 21.48 ? 107 TRP A NE1 1 ATOM 823 C CE2 . TRP A 1 107 ? -1.352 -25.374 -10.810 1.00 19.61 ? 107 TRP A CE2 1 ATOM 824 C CE3 . TRP A 1 107 ? -3.487 -25.749 -9.708 1.00 22.31 ? 107 TRP A CE3 1 ATOM 825 C CZ2 . TRP A 1 107 ? -1.947 -24.648 -11.829 1.00 20.26 ? 107 TRP A CZ2 1 ATOM 826 C CZ3 . TRP A 1 107 ? -4.085 -24.990 -10.724 1.00 22.02 ? 107 TRP A CZ3 1 ATOM 827 C CH2 . TRP A 1 107 ? -3.315 -24.455 -11.764 1.00 22.08 ? 107 TRP A CH2 1 ATOM 828 N N . TYR A 1 108 ? -3.128 -29.766 -8.608 1.00 22.94 ? 108 TYR A N 1 ATOM 829 C CA . TYR A 1 108 ? -3.894 -30.437 -9.676 1.00 22.83 ? 108 TYR A CA 1 ATOM 830 C C . TYR A 1 108 ? -4.970 -29.553 -10.207 1.00 22.81 ? 108 TYR A C 1 ATOM 831 O O . TYR A 1 108 ? -5.497 -28.729 -9.485 1.00 24.27 ? 108 TYR A O 1 ATOM 832 C CB . TYR A 1 108 ? -4.533 -31.747 -9.191 1.00 23.37 ? 108 TYR A CB 1 ATOM 833 C CG . TYR A 1 108 ? -5.614 -31.599 -8.142 1.00 23.49 ? 108 TYR A CG 1 ATOM 834 C CD1 . TYR A 1 108 ? -6.977 -31.724 -8.474 1.00 23.93 ? 108 TYR A CD1 1 ATOM 835 C CD2 . TYR A 1 108 ? -5.278 -31.360 -6.811 1.00 23.24 ? 108 TYR A CD2 1 ATOM 836 C CE1 . TYR A 1 108 ? -7.979 -31.611 -7.485 1.00 24.63 ? 108 TYR A CE1 1 ATOM 837 C CE2 . TYR A 1 108 ? -6.249 -31.227 -5.822 1.00 24.52 ? 108 TYR A CE2 1 ATOM 838 C CZ . TYR A 1 108 ? -7.594 -31.363 -6.148 1.00 25.60 ? 108 TYR A CZ 1 ATOM 839 O OH . TYR A 1 108 ? -8.530 -31.216 -5.133 1.00 26.45 ? 108 TYR A OH 1 ATOM 840 N N . HIS A 1 109 ? -5.329 -29.734 -11.468 1.00 22.74 ? 109 HIS A N 1 ATOM 841 C CA . HIS A 1 109 ? -6.306 -28.873 -12.111 1.00 22.11 ? 109 HIS A CA 1 ATOM 842 C C . HIS A 1 109 ? -6.849 -29.526 -13.328 1.00 22.70 ? 109 HIS A C 1 ATOM 843 O O . HIS A 1 109 ? -6.205 -30.422 -13.926 1.00 23.85 ? 109 HIS A O 1 ATOM 844 C CB . HIS A 1 109 ? -5.693 -27.523 -12.507 1.00 22.51 ? 109 HIS A CB 1 ATOM 845 C CG . HIS A 1 109 ? -4.448 -27.606 -13.346 1.00 21.06 ? 109 HIS A CG 1 ATOM 846 N ND1 . HIS A 1 109 ? -4.475 -27.709 -14.724 1.00 18.90 ? 109 HIS A ND1 1 ATOM 847 C CD2 . HIS A 1 109 ? -3.140 -27.537 -13.001 1.00 21.16 ? 109 HIS A CD2 1 ATOM 848 C CE1 . HIS A 1 109 ? -3.237 -27.711 -15.187 1.00 21.09 ? 109 HIS A CE1 1 ATOM 849 N NE2 . HIS A 1 109 ? -2.405 -27.597 -14.161 1.00 20.75 ? 109 HIS A NE2 1 ATOM 850 N N . SER A 1 110 ? -8.027 -29.085 -13.743 1.00 22.11 ? 110 SER A N 1 ATOM 851 C CA . SER A 1 110 ? -8.567 -29.659 -14.949 1.00 21.62 ? 110 SER A CA 1 ATOM 852 C C . SER A 1 110 ? -7.570 -29.345 -16.022 1.00 21.54 ? 110 SER A C 1 ATOM 853 O O . SER A 1 110 ? -6.959 -28.258 -15.981 1.00 22.65 ? 110 SER A O 1 ATOM 854 C CB . SER A 1 110 ? -9.914 -29.058 -15.312 1.00 21.41 ? 110 SER A CB 1 ATOM 855 O OG . SER A 1 110 ? -10.284 -29.564 -16.596 1.00 21.39 ? 110 SER A OG 1 ATOM 856 N N . HIS A 1 111 ? -7.387 -30.267 -16.964 1.00 20.99 ? 111 HIS A N 1 ATOM 857 C CA . HIS A 1 111 ? -6.597 -29.981 -18.168 1.00 21.08 ? 111 HIS A CA 1 ATOM 858 C C . HIS A 1 111 ? -7.409 -30.131 -19.443 1.00 21.30 ? 111 HIS A C 1 ATOM 859 O O . HIS A 1 111 ? -6.847 -30.486 -20.487 1.00 21.30 ? 111 HIS A O 1 ATOM 860 C CB . HIS A 1 111 ? -5.301 -30.805 -18.253 1.00 20.85 ? 111 HIS A CB 1 ATOM 861 C CG . HIS A 1 111 ? -4.139 -30.044 -18.846 1.00 22.64 ? 111 HIS A CG 1 ATOM 862 N ND1 . HIS A 1 111 ? -4.130 -29.575 -20.153 1.00 23.06 ? 111 HIS A ND1 1 ATOM 863 C CD2 . HIS A 1 111 ? -2.947 -29.679 -18.309 1.00 19.85 ? 111 HIS A CD2 1 ATOM 864 C CE1 . HIS A 1 111 ? -2.980 -28.963 -20.387 1.00 22.09 ? 111 HIS A CE1 1 ATOM 865 N NE2 . HIS A 1 111 ? -2.240 -29.026 -19.290 1.00 21.00 ? 111 HIS A NE2 1 ATOM 866 N N . LEU A 1 112 ? -8.710 -29.833 -19.350 1.00 21.23 ? 112 LEU A N 1 ATOM 867 C CA . LEU A 1 112 ? -9.626 -29.888 -20.475 1.00 21.85 ? 112 LEU A CA 1 ATOM 868 C C . LEU A 1 112 ? -10.182 -28.484 -20.766 1.00 23.91 ? 112 LEU A C 1 ATOM 869 O O . LEU A 1 112 ? -10.830 -27.850 -19.918 1.00 24.90 ? 112 LEU A O 1 ATOM 870 C CB . LEU A 1 112 ? -10.789 -30.859 -20.221 1.00 21.66 ? 112 LEU A CB 1 ATOM 871 C CG . LEU A 1 112 ? -11.999 -30.708 -21.170 1.00 20.79 ? 112 LEU A CG 1 ATOM 872 C CD1 . LEU A 1 112 ? -11.655 -31.159 -22.612 1.00 19.79 ? 112 LEU A CD1 1 ATOM 873 C CD2 . LEU A 1 112 ? -13.263 -31.391 -20.654 1.00 19.51 ? 112 LEU A CD2 1 ATOM 874 N N . SER A 1 113 ? -9.947 -28.013 -21.984 1.00 24.86 ? 113 SER A N 1 ATOM 875 C CA . SER A 1 113 ? -10.274 -26.662 -22.339 1.00 24.77 ? 113 SER A CA 1 ATOM 876 C C . SER A 1 113 ? -9.813 -25.722 -21.208 1.00 25.06 ? 113 SER A C 1 ATOM 877 O O . SER A 1 113 ? -8.687 -25.800 -20.766 1.00 24.86 ? 113 SER A O 1 ATOM 878 C CB . SER A 1 113 ? -11.767 -26.559 -22.612 1.00 24.51 ? 113 SER A CB 1 ATOM 879 O OG . SER A 1 113 ? -12.062 -25.298 -23.186 1.00 25.54 ? 113 SER A OG 1 ATOM 880 N N . THR A 1 114 ? -10.707 -24.858 -20.743 1.00 25.63 ? 114 THR A N 1 ATOM 881 C CA . THR A 1 114 ? -10.403 -23.844 -19.769 1.00 25.57 ? 114 THR A CA 1 ATOM 882 C C . THR A 1 114 ? -11.209 -24.085 -18.513 1.00 25.89 ? 114 THR A C 1 ATOM 883 O O . THR A 1 114 ? -11.583 -23.127 -17.817 1.00 26.14 ? 114 THR A O 1 ATOM 884 C CB . THR A 1 114 ? -10.796 -22.490 -20.286 1.00 25.63 ? 114 THR A CB 1 ATOM 885 O OG1 . THR A 1 114 ? -12.091 -22.585 -20.872 1.00 25.08 ? 114 THR A OG1 1 ATOM 886 C CG2 . THR A 1 114 ? -9.792 -22.002 -21.327 1.00 27.09 ? 114 THR A CG2 1 ATOM 887 N N . GLN A 1 115 ? -11.448 -25.361 -18.212 1.00 25.42 ? 115 GLN A N 1 ATOM 888 C CA . GLN A 1 115 ? -12.350 -25.731 -17.149 1.00 25.26 ? 115 GLN A CA 1 ATOM 889 C C . GLN A 1 115 ? -11.734 -25.508 -15.766 1.00 26.44 ? 115 GLN A C 1 ATOM 890 O O . GLN A 1 115 ? -12.487 -25.280 -14.791 1.00 26.93 ? 115 GLN A O 1 ATOM 891 C CB . GLN A 1 115 ? -12.853 -27.155 -17.381 1.00 25.18 ? 115 GLN A CB 1 ATOM 892 C CG . GLN A 1 115 ? -13.151 -28.001 -16.190 1.00 24.06 ? 115 GLN A CG 1 ATOM 893 C CD . GLN A 1 115 ? -13.688 -29.359 -16.584 1.00 24.26 ? 115 GLN A CD 1 ATOM 894 O OE1 . GLN A 1 115 ? -14.852 -29.498 -16.947 1.00 24.49 ? 115 GLN A OE1 1 ATOM 895 N NE2 . GLN A 1 115 ? -12.843 -30.363 -16.518 1.00 22.49 ? 115 GLN A NE2 1 ATOM 896 N N . TYR A 1 116 ? -10.397 -25.510 -15.654 1.00 26.16 ? 116 TYR A N 1 ATOM 897 C CA . TYR A 1 116 ? -9.824 -25.258 -14.342 1.00 26.22 ? 116 TYR A CA 1 ATOM 898 C C . TYR A 1 116 ? -10.260 -23.923 -13.795 1.00 27.05 ? 116 TYR A C 1 ATOM 899 O O . TYR A 1 116 ? -10.471 -23.797 -12.584 1.00 27.11 ? 116 TYR A O 1 ATOM 900 C CB . TYR A 1 116 ? -8.322 -25.600 -14.215 1.00 26.87 ? 116 TYR A CB 1 ATOM 901 C CG . TYR A 1 116 ? -7.216 -24.575 -14.472 1.00 26.49 ? 116 TYR A CG 1 ATOM 902 C CD1 . TYR A 1 116 ? -6.881 -23.628 -13.518 1.00 29.98 ? 116 TYR A CD1 1 ATOM 903 C CD2 . TYR A 1 116 ? -6.419 -24.652 -15.604 1.00 25.67 ? 116 TYR A CD2 1 ATOM 904 C CE1 . TYR A 1 116 ? -5.820 -22.696 -13.729 1.00 29.42 ? 116 TYR A CE1 1 ATOM 905 C CE2 . TYR A 1 116 ? -5.369 -23.762 -15.824 1.00 26.68 ? 116 TYR A CE2 1 ATOM 906 C CZ . TYR A 1 116 ? -5.061 -22.784 -14.879 1.00 28.23 ? 116 TYR A CZ 1 ATOM 907 O OH . TYR A 1 116 ? -4.018 -21.879 -15.082 1.00 27.57 ? 116 TYR A OH 1 ATOM 908 N N . CYS A 1 117 ? -10.468 -22.939 -14.683 1.00 27.12 ? 117 CYS A N 1 ATOM 909 C CA . CYS A 1 117 ? -10.939 -21.629 -14.248 1.00 27.95 ? 117 CYS A CA 1 ATOM 910 C C . CYS A 1 117 ? -12.338 -21.699 -13.564 1.00 28.28 ? 117 CYS A C 1 ATOM 911 O O . CYS A 1 117 ? -12.656 -20.890 -12.673 1.00 28.75 ? 117 CYS A O 1 ATOM 912 C CB . CYS A 1 117 ? -10.978 -20.680 -15.423 1.00 27.67 ? 117 CYS A CB 1 ATOM 913 S SG . CYS A 1 117 ? -9.544 -20.809 -16.501 1.00 32.01 ? 117 CYS A SG 1 ATOM 914 N N . ASP A 1 118 ? -13.167 -22.662 -13.968 1.00 26.98 ? 118 ASP A N 1 ATOM 915 C CA . ASP A 1 118 ? -14.453 -22.829 -13.313 1.00 26.05 ? 118 ASP A CA 1 ATOM 916 C C . ASP A 1 118 ? -14.365 -23.571 -11.991 1.00 25.48 ? 118 ASP A C 1 ATOM 917 O O . ASP A 1 118 ? -15.389 -23.836 -11.377 1.00 25.49 ? 118 ASP A O 1 ATOM 918 C CB . ASP A 1 118 ? -15.504 -23.457 -14.235 1.00 25.80 ? 118 ASP A CB 1 ATOM 919 C CG . ASP A 1 118 ? -15.969 -22.507 -15.269 1.00 24.72 ? 118 ASP A CG 1 ATOM 920 O OD1 . ASP A 1 118 ? -15.946 -21.300 -14.977 1.00 26.44 ? 118 ASP A OD1 1 ATOM 921 O OD2 . ASP A 1 118 ? -16.315 -22.944 -16.376 1.00 22.97 ? 118 ASP A OD2 1 ATOM 922 N N . GLY A 1 119 ? -13.160 -23.896 -11.546 1.00 24.63 ? 119 GLY A N 1 ATOM 923 C CA . GLY A 1 119 ? -12.992 -24.241 -10.135 1.00 24.17 ? 119 GLY A CA 1 ATOM 924 C C . GLY A 1 119 ? -12.353 -25.573 -9.808 1.00 24.33 ? 119 GLY A C 1 ATOM 925 O O . GLY A 1 119 ? -12.129 -25.866 -8.605 1.00 24.40 ? 119 GLY A O 1 ATOM 926 N N . LEU A 1 120 ? -12.093 -26.401 -10.835 1.00 23.14 ? 120 LEU A N 1 ATOM 927 C CA . LEU A 1 120 ? -11.438 -27.681 -10.588 1.00 23.06 ? 120 LEU A CA 1 ATOM 928 C C . LEU A 1 120 ? -9.918 -27.494 -10.519 1.00 23.23 ? 120 LEU A C 1 ATOM 929 O O . LEU A 1 120 ? -9.195 -27.765 -11.497 1.00 23.80 ? 120 LEU A O 1 ATOM 930 C CB . LEU A 1 120 ? -11.846 -28.777 -11.581 1.00 22.47 ? 120 LEU A CB 1 ATOM 931 C CG . LEU A 1 120 ? -11.812 -30.253 -11.066 1.00 22.02 ? 120 LEU A CG 1 ATOM 932 C CD1 . LEU A 1 120 ? -12.075 -31.301 -12.193 1.00 19.94 ? 120 LEU A CD1 1 ATOM 933 C CD2 . LEU A 1 120 ? -10.547 -30.624 -10.335 1.00 18.46 ? 120 LEU A CD2 1 ATOM 934 N N . ARG A 1 121 ? -9.459 -27.024 -9.358 1.00 22.30 ? 121 ARG A N 1 ATOM 935 C CA . ARG A 1 121 ? -8.057 -26.801 -9.092 1.00 22.25 ? 121 ARG A CA 1 ATOM 936 C C . ARG A 1 121 ? -7.764 -26.793 -7.587 1.00 23.14 ? 121 ARG A C 1 ATOM 937 O O . ARG A 1 121 ? -8.403 -26.084 -6.812 1.00 22.39 ? 121 ARG A O 1 ATOM 938 C CB . ARG A 1 121 ? -7.629 -25.466 -9.677 1.00 22.31 ? 121 ARG A CB 1 ATOM 939 C CG . ARG A 1 121 ? -8.634 -24.311 -9.421 1.00 22.29 ? 121 ARG A CG 1 ATOM 940 C CD . ARG A 1 121 ? -8.090 -22.940 -9.819 1.00 21.11 ? 121 ARG A CD 1 ATOM 941 N NE . ARG A 1 121 ? -9.025 -21.914 -9.441 1.00 18.92 ? 121 ARG A NE 1 ATOM 942 C CZ . ARG A 1 121 ? -9.136 -20.727 -10.026 1.00 20.84 ? 121 ARG A CZ 1 ATOM 943 N NH1 . ARG A 1 121 ? -10.069 -19.878 -9.626 1.00 20.66 ? 121 ARG A NH1 1 ATOM 944 N NH2 . ARG A 1 121 ? -8.354 -20.396 -11.024 1.00 19.95 ? 121 ARG A NH2 1 ATOM 945 N N . GLY A 1 122 ? -6.770 -27.564 -7.185 1.00 24.03 ? 122 GLY A N 1 ATOM 946 C CA . GLY A 1 122 ? -6.348 -27.572 -5.798 1.00 26.01 ? 122 GLY A CA 1 ATOM 947 C C . GLY A 1 122 ? -4.874 -27.902 -5.598 1.00 26.29 ? 122 GLY A C 1 ATOM 948 O O . GLY A 1 122 ? -4.233 -28.351 -6.527 1.00 26.27 ? 122 GLY A O 1 ATOM 949 N N . PRO A 1 123 ? -4.346 -27.687 -4.373 1.00 26.57 ? 123 PRO A N 1 ATOM 950 C CA . PRO A 1 123 ? -2.941 -27.907 -4.109 1.00 27.04 ? 123 PRO A CA 1 ATOM 951 C C . PRO A 1 123 ? -2.642 -29.358 -3.692 1.00 27.62 ? 123 PRO A C 1 ATOM 952 O O . PRO A 1 123 ? -3.516 -30.023 -3.122 1.00 27.84 ? 123 PRO A O 1 ATOM 953 C CB . PRO A 1 123 ? -2.662 -26.948 -2.932 1.00 26.83 ? 123 PRO A CB 1 ATOM 954 C CG . PRO A 1 123 ? -3.940 -26.953 -2.154 1.00 26.84 ? 123 PRO A CG 1 ATOM 955 C CD . PRO A 1 123 ? -5.060 -27.205 -3.169 1.00 26.55 ? 123 PRO A CD 1 ATOM 956 N N . ILE A 1 124 ? -1.414 -29.818 -3.980 1.00 27.73 ? 124 ILE A N 1 ATOM 957 C CA . ILE A 1 124 ? -0.899 -31.114 -3.534 1.00 27.70 ? 124 ILE A CA 1 ATOM 958 C C . ILE A 1 124 ? 0.390 -30.861 -2.763 1.00 27.77 ? 124 ILE A C 1 ATOM 959 O O . ILE A 1 124 ? 1.166 -29.990 -3.119 1.00 28.59 ? 124 ILE A O 1 ATOM 960 C CB . ILE A 1 124 ? -0.583 -32.052 -4.719 1.00 27.67 ? 124 ILE A CB 1 ATOM 961 C CG1 . ILE A 1 124 ? -1.847 -32.344 -5.528 1.00 28.58 ? 124 ILE A CG1 1 ATOM 962 C CG2 . ILE A 1 124 ? -0.030 -33.354 -4.221 1.00 28.24 ? 124 ILE A CG2 1 ATOM 963 C CD1 . ILE A 1 124 ? -1.626 -33.117 -6.835 1.00 26.70 ? 124 ILE A CD1 1 ATOM 964 N N . VAL A 1 125 ? 0.620 -31.598 -1.692 1.00 27.16 ? 125 VAL A N 1 ATOM 965 C CA . VAL A 1 125 ? 1.904 -31.529 -1.035 1.00 26.45 ? 125 VAL A CA 1 ATOM 966 C C . VAL A 1 125 ? 2.447 -32.973 -0.833 1.00 27.56 ? 125 VAL A C 1 ATOM 967 O O . VAL A 1 125 ? 1.717 -33.836 -0.347 1.00 27.44 ? 125 VAL A O 1 ATOM 968 C CB . VAL A 1 125 ? 1.864 -30.752 0.298 1.00 25.66 ? 125 VAL A CB 1 ATOM 969 C CG1 . VAL A 1 125 ? 3.271 -30.665 0.893 1.00 24.43 ? 125 VAL A CG1 1 ATOM 970 C CG2 . VAL A 1 125 ? 1.330 -29.399 0.114 1.00 22.78 ? 125 VAL A CG2 1 ATOM 971 N N . VAL A 1 126 ? 3.711 -33.203 -1.239 1.00 27.56 ? 126 VAL A N 1 ATOM 972 C CA . VAL A 1 126 ? 4.427 -34.454 -1.008 1.00 28.00 ? 126 VAL A CA 1 ATOM 973 C C . VAL A 1 126 ? 5.580 -34.136 -0.053 1.00 29.02 ? 126 VAL A C 1 ATOM 974 O O . VAL A 1 126 ? 6.529 -33.435 -0.420 1.00 30.25 ? 126 VAL A O 1 ATOM 975 C CB . VAL A 1 126 ? 5.012 -35.013 -2.309 1.00 27.79 ? 126 VAL A CB 1 ATOM 976 C CG1 . VAL A 1 126 ? 5.772 -36.284 -2.047 1.00 26.75 ? 126 VAL A CG1 1 ATOM 977 C CG2 . VAL A 1 126 ? 3.930 -35.228 -3.335 1.00 25.74 ? 126 VAL A CG2 1 ATOM 978 N N . TYR A 1 127 ? 5.476 -34.619 1.177 1.00 29.33 ? 127 TYR A N 1 ATOM 979 C CA . TYR A 1 127 ? 6.437 -34.323 2.223 1.00 29.31 ? 127 TYR A CA 1 ATOM 980 C C . TYR A 1 127 ? 7.670 -35.210 2.077 1.00 30.61 ? 127 TYR A C 1 ATOM 981 O O . TYR A 1 127 ? 7.582 -36.365 1.641 1.00 29.63 ? 127 TYR A O 1 ATOM 982 C CB . TYR A 1 127 ? 5.800 -34.532 3.605 1.00 28.20 ? 127 TYR A CB 1 ATOM 983 C CG . TYR A 1 127 ? 4.638 -33.625 3.840 1.00 27.70 ? 127 TYR A CG 1 ATOM 984 C CD1 . TYR A 1 127 ? 3.322 -34.079 3.696 1.00 28.94 ? 127 TYR A CD1 1 ATOM 985 C CD2 . TYR A 1 127 ? 4.835 -32.289 4.178 1.00 28.67 ? 127 TYR A CD2 1 ATOM 986 C CE1 . TYR A 1 127 ? 2.230 -33.211 3.876 1.00 26.74 ? 127 TYR A CE1 1 ATOM 987 C CE2 . TYR A 1 127 ? 3.744 -31.422 4.370 1.00 28.32 ? 127 TYR A CE2 1 ATOM 988 C CZ . TYR A 1 127 ? 2.462 -31.893 4.202 1.00 25.83 ? 127 TYR A CZ 1 ATOM 989 O OH . TYR A 1 127 ? 1.438 -31.040 4.378 1.00 24.89 ? 127 TYR A OH 1 ATOM 990 N N . ASP A 1 128 ? 8.825 -34.660 2.432 1.00 31.99 ? 128 ASP A N 1 ATOM 991 C CA . ASP A 1 128 ? 10.006 -35.483 2.548 1.00 33.57 ? 128 ASP A CA 1 ATOM 992 C C . ASP A 1 128 ? 10.304 -35.705 4.026 1.00 34.64 ? 128 ASP A C 1 ATOM 993 O O . ASP A 1 128 ? 10.669 -34.778 4.732 1.00 33.93 ? 128 ASP A O 1 ATOM 994 C CB . ASP A 1 128 ? 11.179 -34.806 1.859 1.00 34.20 ? 128 ASP A CB 1 ATOM 995 C CG . ASP A 1 128 ? 12.393 -35.687 1.785 1.00 35.27 ? 128 ASP A CG 1 ATOM 996 O OD1 . ASP A 1 128 ? 12.579 -36.491 2.705 1.00 39.85 ? 128 ASP A OD1 1 ATOM 997 O OD2 . ASP A 1 128 ? 13.180 -35.576 0.827 1.00 36.54 ? 128 ASP A OD2 1 ATOM 998 N N . PRO A 1 129 ? 10.190 -36.956 4.499 1.00 36.26 ? 129 PRO A N 1 ATOM 999 C CA . PRO A 1 129 ? 10.499 -37.165 5.892 1.00 37.36 ? 129 PRO A CA 1 ATOM 1000 C C . PRO A 1 129 ? 11.972 -36.842 6.177 1.00 38.74 ? 129 PRO A C 1 ATOM 1001 O O . PRO A 1 129 ? 12.326 -36.689 7.342 1.00 39.61 ? 129 PRO A O 1 ATOM 1002 C CB . PRO A 1 129 ? 10.208 -38.647 6.089 1.00 37.09 ? 129 PRO A CB 1 ATOM 1003 C CG . PRO A 1 129 ? 10.402 -39.232 4.775 1.00 36.37 ? 129 PRO A CG 1 ATOM 1004 C CD . PRO A 1 129 ? 9.855 -38.229 3.833 1.00 36.43 ? 129 PRO A CD 1 ATOM 1005 N N . GLN A 1 130 ? 12.796 -36.697 5.132 1.00 39.02 ? 130 GLN A N 1 ATOM 1006 C CA . GLN A 1 130 ? 14.174 -36.196 5.267 1.00 39.57 ? 130 GLN A CA 1 ATOM 1007 C C . GLN A 1 130 ? 14.402 -34.794 4.671 1.00 38.23 ? 130 GLN A C 1 ATOM 1008 O O . GLN A 1 130 ? 15.450 -34.520 4.109 1.00 38.49 ? 130 GLN A O 1 ATOM 1009 C CB . GLN A 1 130 ? 15.163 -37.178 4.594 1.00 40.14 ? 130 GLN A CB 1 ATOM 1010 C CG . GLN A 1 130 ? 15.435 -38.464 5.368 1.00 45.04 ? 130 GLN A CG 1 ATOM 1011 C CD . GLN A 1 130 ? 15.453 -38.276 6.895 1.00 50.81 ? 130 GLN A CD 1 ATOM 1012 O OE1 . GLN A 1 130 ? 14.636 -38.872 7.601 1.00 53.07 ? 130 GLN A OE1 1 ATOM 1013 N NE2 . GLN A 1 130 ? 16.388 -37.449 7.407 1.00 53.71 ? 130 GLN A NE2 1 ATOM 1014 N N . ASP A 1 131 ? 13.433 -33.909 4.754 1.00 37.20 ? 131 ASP A N 1 ATOM 1015 C CA . ASP A 1 131 ? 13.567 -32.595 4.088 1.00 36.23 ? 131 ASP A CA 1 ATOM 1016 C C . ASP A 1 131 ? 14.784 -31.766 4.554 1.00 35.89 ? 131 ASP A C 1 ATOM 1017 O O . ASP A 1 131 ? 14.847 -31.380 5.721 1.00 35.45 ? 131 ASP A O 1 ATOM 1018 C CB . ASP A 1 131 ? 12.299 -31.782 4.281 1.00 35.43 ? 131 ASP A CB 1 ATOM 1019 C CG . ASP A 1 131 ? 12.081 -30.783 3.183 1.00 35.27 ? 131 ASP A CG 1 ATOM 1020 O OD1 . ASP A 1 131 ? 12.991 -29.985 2.891 1.00 30.89 ? 131 ASP A OD1 1 ATOM 1021 O OD2 . ASP A 1 131 ? 10.966 -30.781 2.621 1.00 37.15 ? 131 ASP A OD2 1 ATOM 1022 N N . PRO A 1 132 ? 15.743 -31.477 3.638 1.00 35.51 ? 132 PRO A N 1 ATOM 1023 C CA . PRO A 1 132 ? 16.939 -30.694 3.977 1.00 35.21 ? 132 PRO A CA 1 ATOM 1024 C C . PRO A 1 132 ? 16.657 -29.281 4.499 1.00 34.92 ? 132 PRO A C 1 ATOM 1025 O O . PRO A 1 132 ? 17.557 -28.645 5.095 1.00 35.40 ? 132 PRO A O 1 ATOM 1026 C CB . PRO A 1 132 ? 17.720 -30.647 2.643 1.00 35.22 ? 132 PRO A CB 1 ATOM 1027 C CG . PRO A 1 132 ? 16.722 -30.940 1.602 1.00 33.96 ? 132 PRO A CG 1 ATOM 1028 C CD . PRO A 1 132 ? 15.784 -31.905 2.227 1.00 35.20 ? 132 PRO A CD 1 ATOM 1029 N N . HIS A 1 133 ? 15.442 -28.784 4.284 1.00 33.79 ? 133 HIS A N 1 ATOM 1030 C CA . HIS A 1 133 ? 15.059 -27.501 4.883 1.00 33.06 ? 133 HIS A CA 1 ATOM 1031 C C . HIS A 1 133 ? 14.273 -27.639 6.167 1.00 33.61 ? 133 HIS A C 1 ATOM 1032 O O . HIS A 1 133 ? 13.898 -26.644 6.758 1.00 33.72 ? 133 HIS A O 1 ATOM 1033 C CB . HIS A 1 133 ? 14.262 -26.666 3.913 1.00 32.06 ? 133 HIS A CB 1 ATOM 1034 C CG . HIS A 1 133 ? 15.018 -26.297 2.691 1.00 28.64 ? 133 HIS A CG 1 ATOM 1035 N ND1 . HIS A 1 133 ? 16.336 -25.924 2.727 1.00 27.48 ? 133 HIS A ND1 1 ATOM 1036 C CD2 . HIS A 1 133 ? 14.634 -26.206 1.402 1.00 28.02 ? 133 HIS A CD2 1 ATOM 1037 C CE1 . HIS A 1 133 ? 16.739 -25.616 1.510 1.00 29.63 ? 133 HIS A CE1 1 ATOM 1038 N NE2 . HIS A 1 133 ? 15.723 -25.782 0.684 1.00 29.36 ? 133 HIS A NE2 1 ATOM 1039 N N . LYS A 1 134 ? 14.062 -28.878 6.600 1.00 34.50 ? 134 LYS A N 1 ATOM 1040 C CA . LYS A 1 134 ? 13.200 -29.229 7.739 1.00 35.63 ? 134 LYS A CA 1 ATOM 1041 C C . LYS A 1 134 ? 13.539 -28.532 9.052 1.00 35.23 ? 134 LYS A C 1 ATOM 1042 O O . LYS A 1 134 ? 12.642 -28.117 9.807 1.00 35.41 ? 134 LYS A O 1 ATOM 1043 C CB . LYS A 1 134 ? 13.163 -30.765 7.928 1.00 36.21 ? 134 LYS A CB 1 ATOM 1044 C CG . LYS A 1 134 ? 12.396 -31.231 9.138 1.00 38.54 ? 134 LYS A CG 1 ATOM 1045 C CD . LYS A 1 134 ? 11.023 -30.460 9.365 1.00 41.11 ? 134 LYS A CD 1 ATOM 1046 C CE . LYS A 1 134 ? 10.639 -30.426 10.894 1.00 40.61 ? 134 LYS A CE 1 ATOM 1047 N NZ . LYS A 1 134 ? 9.518 -29.518 11.183 1.00 40.97 ? 134 LYS A NZ 1 ATOM 1048 N N . SER A 1 135 ? 14.820 -28.374 9.327 1.00 34.86 ? 135 SER A N 1 ATOM 1049 C CA . SER A 1 135 ? 15.163 -27.808 10.602 1.00 34.99 ? 135 SER A CA 1 ATOM 1050 C C . SER A 1 135 ? 15.080 -26.294 10.633 1.00 35.14 ? 135 SER A C 1 ATOM 1051 O O . SER A 1 135 ? 15.321 -25.675 11.681 1.00 36.09 ? 135 SER A O 1 ATOM 1052 C CB . SER A 1 135 ? 16.482 -28.379 11.112 1.00 35.57 ? 135 SER A CB 1 ATOM 1053 O OG . SER A 1 135 ? 16.254 -29.682 11.633 1.00 35.68 ? 135 SER A OG 1 ATOM 1054 N N . LEU A 1 136 ? 14.671 -25.694 9.515 1.00 34.28 ? 136 LEU A N 1 ATOM 1055 C CA . LEU A 1 136 ? 14.341 -24.272 9.496 1.00 33.88 ? 136 LEU A CA 1 ATOM 1056 C C . LEU A 1 136 ? 12.947 -23.874 10.023 1.00 34.13 ? 136 LEU A C 1 ATOM 1057 O O . LEU A 1 136 ? 12.631 -22.648 10.106 1.00 33.67 ? 136 LEU A O 1 ATOM 1058 C CB . LEU A 1 136 ? 14.463 -23.727 8.081 1.00 34.23 ? 136 LEU A CB 1 ATOM 1059 C CG . LEU A 1 136 ? 15.822 -23.559 7.424 1.00 33.69 ? 136 LEU A CG 1 ATOM 1060 C CD1 . LEU A 1 136 ? 15.588 -22.991 6.014 1.00 29.37 ? 136 LEU A CD1 1 ATOM 1061 C CD2 . LEU A 1 136 ? 16.702 -22.658 8.320 1.00 32.40 ? 136 LEU A CD2 1 ATOM 1062 N N . TYR A 1 137 ? 12.091 -24.858 10.331 1.00 34.02 ? 137 TYR A N 1 ATOM 1063 C CA . TYR A 1 137 ? 10.707 -24.517 10.768 1.00 34.56 ? 137 TYR A CA 1 ATOM 1064 C C . TYR A 1 137 ? 10.058 -25.526 11.714 1.00 35.13 ? 137 TYR A C 1 ATOM 1065 O O . TYR A 1 137 ? 10.483 -26.683 11.792 1.00 35.53 ? 137 TYR A O 1 ATOM 1066 C CB . TYR A 1 137 ? 9.771 -24.272 9.550 1.00 34.04 ? 137 TYR A CB 1 ATOM 1067 C CG . TYR A 1 137 ? 9.762 -25.412 8.578 1.00 32.96 ? 137 TYR A CG 1 ATOM 1068 C CD1 . TYR A 1 137 ? 10.532 -25.353 7.421 1.00 31.40 ? 137 TYR A CD1 1 ATOM 1069 C CD2 . TYR A 1 137 ? 9.030 -26.575 8.832 1.00 31.17 ? 137 TYR A CD2 1 ATOM 1070 C CE1 . TYR A 1 137 ? 10.565 -26.386 6.548 1.00 28.63 ? 137 TYR A CE1 1 ATOM 1071 C CE2 . TYR A 1 137 ? 9.068 -27.626 7.937 1.00 30.81 ? 137 TYR A CE2 1 ATOM 1072 C CZ . TYR A 1 137 ? 9.846 -27.504 6.801 1.00 30.34 ? 137 TYR A CZ 1 ATOM 1073 O OH . TYR A 1 137 ? 9.918 -28.516 5.895 1.00 33.98 ? 137 TYR A OH 1 ATOM 1074 N N . ASP A 1 138 ? 8.993 -25.087 12.385 1.00 35.65 ? 138 ASP A N 1 ATOM 1075 C CA . ASP A 1 138 ? 8.217 -25.945 13.297 1.00 36.28 ? 138 ASP A CA 1 ATOM 1076 C C . ASP A 1 138 ? 6.935 -26.507 12.716 1.00 36.09 ? 138 ASP A C 1 ATOM 1077 O O . ASP A 1 138 ? 6.526 -27.627 13.049 1.00 36.44 ? 138 ASP A O 1 ATOM 1078 C CB . ASP A 1 138 ? 7.869 -25.168 14.546 1.00 35.72 ? 138 ASP A CB 1 ATOM 1079 C CG . ASP A 1 138 ? 9.079 -24.585 15.184 1.00 38.42 ? 138 ASP A CG 1 ATOM 1080 O OD1 . ASP A 1 138 ? 10.036 -25.368 15.441 1.00 37.48 ? 138 ASP A OD1 1 ATOM 1081 O OD2 . ASP A 1 138 ? 9.082 -23.334 15.372 1.00 41.18 ? 138 ASP A OD2 1 ATOM 1082 N N . VAL A 1 139 ? 6.287 -25.715 11.870 1.00 35.47 ? 139 VAL A N 1 ATOM 1083 C CA . VAL A 1 139 ? 4.977 -26.077 11.374 1.00 34.42 ? 139 VAL A CA 1 ATOM 1084 C C . VAL A 1 139 ? 4.957 -26.223 9.860 1.00 34.14 ? 139 VAL A C 1 ATOM 1085 O O . VAL A 1 139 ? 5.459 -25.370 9.129 1.00 33.82 ? 139 VAL A O 1 ATOM 1086 C CB . VAL A 1 139 ? 3.931 -25.104 11.863 1.00 33.84 ? 139 VAL A CB 1 ATOM 1087 C CG1 . VAL A 1 139 ? 2.558 -25.591 11.479 1.00 34.14 ? 139 VAL A CG1 1 ATOM 1088 C CG2 . VAL A 1 139 ? 4.036 -24.973 13.385 1.00 33.71 ? 139 VAL A CG2 1 ATOM 1089 N N . ASP A 1 140 ? 4.380 -27.334 9.414 1.00 34.01 ? 140 ASP A N 1 ATOM 1090 C CA . ASP A 1 140 ? 4.212 -27.617 7.999 1.00 34.06 ? 140 ASP A CA 1 ATOM 1091 C C . ASP A 1 140 ? 2.996 -28.519 7.813 1.00 33.85 ? 140 ASP A C 1 ATOM 1092 O O . ASP A 1 140 ? 3.116 -29.740 7.709 1.00 33.95 ? 140 ASP A O 1 ATOM 1093 C CB . ASP A 1 140 ? 5.470 -28.306 7.447 1.00 33.69 ? 140 ASP A CB 1 ATOM 1094 C CG . ASP A 1 140 ? 5.409 -28.513 5.963 1.00 32.55 ? 140 ASP A CG 1 ATOM 1095 O OD1 . ASP A 1 140 ? 4.654 -27.776 5.292 1.00 30.51 ? 140 ASP A OD1 1 ATOM 1096 O OD2 . ASP A 1 140 ? 6.120 -29.411 5.479 1.00 31.59 ? 140 ASP A OD2 1 ATOM 1097 N N . ASP A 1 141 ? 1.816 -27.931 7.776 1.00 33.47 ? 141 ASP A N 1 ATOM 1098 C CA . ASP A 1 141 ? 0.641 -28.766 7.649 1.00 33.01 ? 141 ASP A CA 1 ATOM 1099 C C . ASP A 1 141 ? -0.370 -28.245 6.658 1.00 32.62 ? 141 ASP A C 1 ATOM 1100 O O . ASP A 1 141 ? -0.020 -27.466 5.808 1.00 32.63 ? 141 ASP A O 1 ATOM 1101 C CB . ASP A 1 141 ? 0.037 -29.119 9.016 1.00 32.56 ? 141 ASP A CB 1 ATOM 1102 C CG . ASP A 1 141 ? -0.193 -27.922 9.903 1.00 32.46 ? 141 ASP A CG 1 ATOM 1103 O OD1 . ASP A 1 141 ? -0.553 -26.826 9.436 1.00 28.97 ? 141 ASP A OD1 1 ATOM 1104 O OD2 . ASP A 1 141 ? -0.046 -28.117 11.129 1.00 36.94 ? 141 ASP A OD2 1 ATOM 1105 N N . ASP A 1 142 ? -1.599 -28.739 6.741 1.00 32.95 ? 142 ASP A N 1 ATOM 1106 C CA . ASP A 1 142 ? -2.693 -28.261 5.921 1.00 33.23 ? 142 ASP A CA 1 ATOM 1107 C C . ASP A 1 142 ? -2.887 -26.755 6.121 1.00 33.41 ? 142 ASP A C 1 ATOM 1108 O O . ASP A 1 142 ? -3.279 -26.046 5.191 1.00 34.41 ? 142 ASP A O 1 ATOM 1109 C CB . ASP A 1 142 ? -4.001 -28.995 6.272 1.00 33.26 ? 142 ASP A CB 1 ATOM 1110 C CG . ASP A 1 142 ? -3.944 -30.510 6.007 1.00 34.56 ? 142 ASP A CG 1 ATOM 1111 O OD1 . ASP A 1 142 ? -5.028 -31.091 5.922 1.00 34.93 ? 142 ASP A OD1 1 ATOM 1112 O OD2 . ASP A 1 142 ? -2.861 -31.135 5.892 1.00 36.22 ? 142 ASP A OD2 1 ATOM 1113 N N . SER A 1 143 ? -2.610 -26.253 7.319 1.00 32.92 ? 143 SER A N 1 ATOM 1114 C CA . SER A 1 143 ? -2.852 -24.833 7.583 1.00 32.76 ? 143 SER A CA 1 ATOM 1115 C C . SER A 1 143 ? -1.800 -23.957 6.903 1.00 33.23 ? 143 SER A C 1 ATOM 1116 O O . SER A 1 143 ? -2.021 -22.718 6.704 1.00 33.54 ? 143 SER A O 1 ATOM 1117 C CB . SER A 1 143 ? -2.929 -24.538 9.096 1.00 32.69 ? 143 SER A CB 1 ATOM 1118 O OG . SER A 1 143 ? -1.640 -24.556 9.702 1.00 32.04 ? 143 SER A OG 1 ATOM 1119 N N . THR A 1 144 ? -0.657 -24.563 6.547 1.00 32.47 ? 144 THR A N 1 ATOM 1120 C CA . THR A 1 144 ? 0.396 -23.748 5.929 1.00 32.56 ? 144 THR A CA 1 ATOM 1121 C C . THR A 1 144 ? 0.416 -23.744 4.394 1.00 32.25 ? 144 THR A C 1 ATOM 1122 O O . THR A 1 144 ? 1.371 -23.262 3.769 1.00 33.05 ? 144 THR A O 1 ATOM 1123 C CB . THR A 1 144 ? 1.782 -23.944 6.544 1.00 32.17 ? 144 THR A CB 1 ATOM 1124 O OG1 . THR A 1 144 ? 2.320 -25.191 6.127 1.00 33.40 ? 144 THR A OG1 1 ATOM 1125 C CG2 . THR A 1 144 ? 1.697 -23.890 8.074 1.00 33.61 ? 144 THR A CG2 1 ATOM 1126 N N . VAL A 1 145 ? -0.654 -24.247 3.783 1.00 30.92 ? 145 VAL A N 1 ATOM 1127 C CA . VAL A 1 145 ? -0.763 -24.175 2.344 1.00 29.57 ? 145 VAL A CA 1 ATOM 1128 C C . VAL A 1 145 ? -1.547 -22.926 2.094 1.00 29.40 ? 145 VAL A C 1 ATOM 1129 O O . VAL A 1 145 ? -2.533 -22.667 2.795 1.00 30.33 ? 145 VAL A O 1 ATOM 1130 C CB . VAL A 1 145 ? -1.426 -25.435 1.769 1.00 29.47 ? 145 VAL A CB 1 ATOM 1131 C CG1 . VAL A 1 145 ? -1.558 -25.333 0.298 1.00 29.15 ? 145 VAL A CG1 1 ATOM 1132 C CG2 . VAL A 1 145 ? -0.570 -26.636 2.070 1.00 28.08 ? 145 VAL A CG2 1 ATOM 1133 N N . ILE A 1 146 ? -1.070 -22.114 1.148 1.00 28.70 ? 146 ILE A N 1 ATOM 1134 C CA . ILE A 1 146 ? -1.642 -20.798 0.858 1.00 27.00 ? 146 ILE A CA 1 ATOM 1135 C C . ILE A 1 146 ? -1.828 -20.720 -0.620 1.00 26.28 ? 146 ILE A C 1 ATOM 1136 O O . ILE A 1 146 ? -0.855 -20.672 -1.347 1.00 26.73 ? 146 ILE A O 1 ATOM 1137 C CB . ILE A 1 146 ? -0.698 -19.630 1.251 1.00 27.25 ? 146 ILE A CB 1 ATOM 1138 C CG1 . ILE A 1 146 ? -0.446 -19.587 2.767 1.00 26.79 ? 146 ILE A CG1 1 ATOM 1139 C CG2 . ILE A 1 146 ? -1.271 -18.264 0.761 1.00 26.67 ? 146 ILE A CG2 1 ATOM 1140 C CD1 . ILE A 1 146 ? 0.463 -18.404 3.215 1.00 27.27 ? 146 ILE A CD1 1 ATOM 1141 N N . THR A 1 147 ? -3.068 -20.697 -1.084 1.00 25.51 ? 147 THR A N 1 ATOM 1142 C CA . THR A 1 147 ? -3.292 -20.661 -2.526 1.00 24.06 ? 147 THR A CA 1 ATOM 1143 C C . THR A 1 147 ? -3.716 -19.279 -2.996 1.00 24.69 ? 147 THR A C 1 ATOM 1144 O O . THR A 1 147 ? -4.353 -18.546 -2.264 1.00 25.36 ? 147 THR A O 1 ATOM 1145 C CB . THR A 1 147 ? -4.274 -21.753 -2.998 1.00 23.33 ? 147 THR A CB 1 ATOM 1146 O OG1 . THR A 1 147 ? -5.592 -21.372 -2.685 1.00 18.79 ? 147 THR A OG1 1 ATOM 1147 C CG2 . THR A 1 147 ? -3.972 -23.085 -2.348 1.00 22.72 ? 147 THR A CG2 1 ATOM 1148 N N . LEU A 1 148 ? -3.324 -18.913 -4.210 1.00 25.16 ? 148 LEU A N 1 ATOM 1149 C CA . LEU A 1 148 ? -3.783 -17.677 -4.829 1.00 25.90 ? 148 LEU A CA 1 ATOM 1150 C C . LEU A 1 148 ? -4.619 -18.114 -6.009 1.00 26.02 ? 148 LEU A C 1 ATOM 1151 O O . LEU A 1 148 ? -4.254 -19.083 -6.674 1.00 26.04 ? 148 LEU A O 1 ATOM 1152 C CB . LEU A 1 148 ? -2.602 -16.829 -5.322 1.00 25.98 ? 148 LEU A CB 1 ATOM 1153 C CG . LEU A 1 148 ? -1.522 -16.506 -4.280 1.00 27.40 ? 148 LEU A CG 1 ATOM 1154 C CD1 . LEU A 1 148 ? -0.322 -15.913 -4.970 1.00 25.36 ? 148 LEU A CD1 1 ATOM 1155 C CD2 . LEU A 1 148 ? -2.061 -15.572 -3.123 1.00 27.48 ? 148 LEU A CD2 1 ATOM 1156 N N . ALA A 1 149 ? -5.735 -17.430 -6.272 1.00 25.87 ? 149 ALA A N 1 ATOM 1157 C CA . ALA A 1 149 ? -6.557 -17.787 -7.408 1.00 26.14 ? 149 ALA A CA 1 ATOM 1158 C C . ALA A 1 149 ? -7.275 -16.560 -7.932 1.00 27.07 ? 149 ALA A C 1 ATOM 1159 O O . ALA A 1 149 ? -7.777 -15.722 -7.137 1.00 27.25 ? 149 ALA A O 1 ATOM 1160 C CB . ALA A 1 149 ? -7.571 -18.883 -7.017 1.00 26.01 ? 149 ALA A CB 1 ATOM 1161 N N . ASP A 1 150 ? -7.362 -16.463 -9.265 1.00 26.67 ? 150 ASP A N 1 ATOM 1162 C CA . ASP A 1 150 ? -8.185 -15.448 -9.886 1.00 25.97 ? 150 ASP A CA 1 ATOM 1163 C C . ASP A 1 150 ? -9.629 -15.961 -9.924 1.00 27.07 ? 150 ASP A C 1 ATOM 1164 O O . ASP A 1 150 ? -9.861 -17.168 -10.075 1.00 26.66 ? 150 ASP A O 1 ATOM 1165 C CB . ASP A 1 150 ? -7.654 -15.147 -11.263 1.00 25.65 ? 150 ASP A CB 1 ATOM 1166 C CG . ASP A 1 150 ? -7.471 -16.395 -12.106 1.00 25.35 ? 150 ASP A CG 1 ATOM 1167 O OD1 . ASP A 1 150 ? -7.306 -17.491 -11.535 1.00 25.11 ? 150 ASP A OD1 1 ATOM 1168 O OD2 . ASP A 1 150 ? -7.468 -16.283 -13.350 1.00 23.66 ? 150 ASP A OD2 1 ATOM 1169 N N . TRP A 1 151 ? -10.598 -15.051 -9.757 1.00 27.77 ? 151 TRP A N 1 ATOM 1170 C CA . TRP A 1 151 ? -12.024 -15.415 -9.746 1.00 28.21 ? 151 TRP A CA 1 ATOM 1171 C C . TRP A 1 151 ? -12.885 -14.488 -10.608 1.00 29.17 ? 151 TRP A C 1 ATOM 1172 O O . TRP A 1 151 ? -12.722 -13.261 -10.616 1.00 28.60 ? 151 TRP A O 1 ATOM 1173 C CB . TRP A 1 151 ? -12.589 -15.545 -8.314 1.00 28.17 ? 151 TRP A CB 1 ATOM 1174 C CG . TRP A 1 151 ? -13.902 -16.323 -8.308 1.00 27.26 ? 151 TRP A CG 1 ATOM 1175 C CD1 . TRP A 1 151 ? -15.140 -15.810 -8.160 1.00 26.46 ? 151 TRP A CD1 1 ATOM 1176 C CD2 . TRP A 1 151 ? -14.081 -17.734 -8.540 1.00 27.87 ? 151 TRP A CD2 1 ATOM 1177 N NE1 . TRP A 1 151 ? -16.076 -16.791 -8.253 1.00 26.23 ? 151 TRP A NE1 1 ATOM 1178 C CE2 . TRP A 1 151 ? -15.458 -17.983 -8.504 1.00 25.79 ? 151 TRP A CE2 1 ATOM 1179 C CE3 . TRP A 1 151 ? -13.207 -18.808 -8.786 1.00 27.53 ? 151 TRP A CE3 1 ATOM 1180 C CZ2 . TRP A 1 151 ? -15.991 -19.260 -8.688 1.00 26.91 ? 151 TRP A CZ2 1 ATOM 1181 C CZ3 . TRP A 1 151 ? -13.737 -20.068 -8.969 1.00 27.02 ? 151 TRP A CZ3 1 ATOM 1182 C CH2 . TRP A 1 151 ? -15.114 -20.290 -8.905 1.00 27.19 ? 151 TRP A CH2 1 ATOM 1183 N N . TYR A 1 152 ? -13.796 -15.107 -11.344 1.00 30.12 ? 152 TYR A N 1 ATOM 1184 C CA . TYR A 1 152 ? -14.625 -14.401 -12.309 1.00 31.71 ? 152 TYR A CA 1 ATOM 1185 C C . TYR A 1 152 ? -16.100 -14.645 -12.040 1.00 32.58 ? 152 TYR A C 1 ATOM 1186 O O . TYR A 1 152 ? -16.530 -15.783 -11.783 1.00 32.75 ? 152 TYR A O 1 ATOM 1187 C CB . TYR A 1 152 ? -14.311 -14.838 -13.753 1.00 31.69 ? 152 TYR A CB 1 ATOM 1188 C CG . TYR A 1 152 ? -12.846 -14.893 -14.101 1.00 31.98 ? 152 TYR A CG 1 ATOM 1189 C CD1 . TYR A 1 152 ? -12.060 -15.998 -13.739 1.00 31.97 ? 152 TYR A CD1 1 ATOM 1190 C CD2 . TYR A 1 152 ? -12.241 -13.851 -14.805 1.00 32.47 ? 152 TYR A CD2 1 ATOM 1191 C CE1 . TYR A 1 152 ? -10.711 -16.057 -14.032 1.00 32.19 ? 152 TYR A CE1 1 ATOM 1192 C CE2 . TYR A 1 152 ? -10.872 -13.903 -15.110 1.00 32.03 ? 152 TYR A CE2 1 ATOM 1193 C CZ . TYR A 1 152 ? -10.127 -15.005 -14.725 1.00 32.03 ? 152 TYR A CZ 1 ATOM 1194 O OH . TYR A 1 152 ? -8.795 -15.052 -15.037 1.00 32.77 ? 152 TYR A OH 1 ATOM 1195 N N . HIS A 1 153 ? -16.872 -13.573 -12.141 1.00 33.28 ? 153 HIS A N 1 ATOM 1196 C CA . HIS A 1 153 ? -18.308 -13.639 -11.938 1.00 34.65 ? 153 HIS A CA 1 ATOM 1197 C C . HIS A 1 153 ? -19.072 -14.290 -13.080 1.00 35.49 ? 153 HIS A C 1 ATOM 1198 O O . HIS A 1 153 ? -20.134 -14.867 -12.863 1.00 35.68 ? 153 HIS A O 1 ATOM 1199 C CB . HIS A 1 153 ? -18.841 -12.254 -11.583 1.00 34.67 ? 153 HIS A CB 1 ATOM 1200 C CG . HIS A 1 153 ? -18.388 -11.791 -10.234 1.00 35.64 ? 153 HIS A CG 1 ATOM 1201 N ND1 . HIS A 1 153 ? -18.507 -10.488 -9.808 1.00 36.72 ? 153 HIS A ND1 1 ATOM 1202 C CD2 . HIS A 1 153 ? -17.800 -12.467 -9.218 1.00 36.24 ? 153 HIS A CD2 1 ATOM 1203 C CE1 . HIS A 1 153 ? -18.031 -10.383 -8.582 1.00 38.33 ? 153 HIS A CE1 1 ATOM 1204 N NE2 . HIS A 1 153 ? -17.590 -11.571 -8.202 1.00 38.57 ? 153 HIS A NE2 1 ATOM 1205 N N . LEU A 1 154 ? -18.524 -14.209 -14.292 1.00 36.88 ? 154 LEU A N 1 ATOM 1206 C CA . LEU A 1 154 ? -19.038 -14.992 -15.420 1.00 37.77 ? 154 LEU A CA 1 ATOM 1207 C C . LEU A 1 154 ? -18.121 -16.187 -15.631 1.00 38.30 ? 154 LEU A C 1 ATOM 1208 O O . LEU A 1 154 ? -16.909 -16.085 -15.428 1.00 39.06 ? 154 LEU A O 1 ATOM 1209 C CB . LEU A 1 154 ? -19.144 -14.133 -16.682 1.00 37.74 ? 154 LEU A CB 1 ATOM 1210 C CG . LEU A 1 154 ? -20.134 -12.950 -16.661 1.00 38.25 ? 154 LEU A CG 1 ATOM 1211 C CD1 . LEU A 1 154 ? -20.142 -12.197 -17.991 1.00 37.80 ? 154 LEU A CD1 1 ATOM 1212 C CD2 . LEU A 1 154 ? -21.552 -13.413 -16.325 1.00 37.98 ? 154 LEU A CD2 1 ATOM 1213 N N . ALA A 1 155 ? -18.684 -17.325 -16.010 1.00 38.70 ? 155 ALA A N 1 ATOM 1214 C CA . ALA A 1 155 ? -17.879 -18.525 -16.198 1.00 39.33 ? 155 ALA A CA 1 ATOM 1215 C C . ALA A 1 155 ? -17.026 -18.382 -17.471 1.00 39.91 ? 155 ALA A C 1 ATOM 1216 O O . ALA A 1 155 ? -17.299 -17.512 -18.316 1.00 39.52 ? 155 ALA A O 1 ATOM 1217 C CB . ALA A 1 155 ? -18.769 -19.765 -16.256 1.00 39.00 ? 155 ALA A CB 1 ATOM 1218 N N . ALA A 1 156 ? -16.007 -19.238 -17.608 1.00 40.12 ? 156 ALA A N 1 ATOM 1219 C CA . ALA A 1 156 ? -15.035 -19.112 -18.681 1.00 40.09 ? 156 ALA A CA 1 ATOM 1220 C C . ALA A 1 156 ? -15.697 -19.099 -20.053 1.00 40.46 ? 156 ALA A C 1 ATOM 1221 O O . ALA A 1 156 ? -15.300 -18.342 -20.926 1.00 40.19 ? 156 ALA A O 1 ATOM 1222 C CB . ALA A 1 156 ? -14.022 -20.221 -18.590 1.00 40.84 ? 156 ALA A CB 1 ATOM 1223 N N . LYS A 1 157 ? -16.718 -19.927 -20.259 1.00 41.15 ? 157 LYS A N 1 ATOM 1224 C CA . LYS A 1 157 ? -17.405 -19.907 -21.567 1.00 41.27 ? 157 LYS A CA 1 ATOM 1225 C C . LYS A 1 157 ? -18.545 -18.890 -21.607 1.00 41.32 ? 157 LYS A C 1 ATOM 1226 O O . LYS A 1 157 ? -19.105 -18.655 -22.663 1.00 42.54 ? 157 LYS A O 1 ATOM 1227 C CB . LYS A 1 157 ? -17.857 -21.310 -22.032 1.00 41.29 ? 157 LYS A CB 1 ATOM 1228 C CG . LYS A 1 157 ? -16.780 -22.389 -21.834 1.00 40.85 ? 157 LYS A CG 1 ATOM 1229 C CD . LYS A 1 157 ? -16.970 -23.630 -22.644 1.00 41.00 ? 157 LYS A CD 1 ATOM 1230 C CE . LYS A 1 157 ? -15.926 -23.691 -23.770 1.00 42.71 ? 157 LYS A CE 1 ATOM 1231 N NZ . LYS A 1 157 ? -14.528 -23.907 -23.298 1.00 39.56 ? 157 LYS A NZ 1 ATOM 1232 N N . VAL A 1 158 ? -18.880 -18.255 -20.492 1.00 40.95 ? 158 VAL A N 1 ATOM 1233 C CA . VAL A 1 158 ? -19.955 -17.276 -20.559 1.00 41.28 ? 158 VAL A CA 1 ATOM 1234 C C . VAL A 1 158 ? -19.477 -15.830 -20.808 1.00 41.31 ? 158 VAL A C 1 ATOM 1235 O O . VAL A 1 158 ? -20.171 -15.069 -21.494 1.00 42.17 ? 158 VAL A O 1 ATOM 1236 C CB . VAL A 1 158 ? -21.001 -17.399 -19.381 1.00 40.92 ? 158 VAL A CB 1 ATOM 1237 C CG1 . VAL A 1 158 ? -20.832 -16.312 -18.394 1.00 40.41 ? 158 VAL A CG1 1 ATOM 1238 C CG2 . VAL A 1 158 ? -22.382 -17.268 -19.922 1.00 42.34 ? 158 VAL A CG2 1 ATOM 1239 N N . GLY A 1 159 ? -18.314 -15.452 -20.270 1.00 40.77 ? 159 GLY A N 1 ATOM 1240 C CA . GLY A 1 159 ? -17.821 -14.073 -20.395 1.00 40.23 ? 159 GLY A CA 1 ATOM 1241 C C . GLY A 1 159 ? -16.888 -13.930 -21.583 1.00 40.06 ? 159 GLY A C 1 ATOM 1242 O O . GLY A 1 159 ? -16.947 -14.728 -22.519 1.00 39.75 ? 159 GLY A O 1 ATOM 1243 N N . SER A 1 160 ? -15.990 -12.947 -21.536 1.00 39.83 ? 160 SER A N 1 ATOM 1244 C CA . SER A 1 160 ? -14.995 -12.788 -22.613 1.00 40.25 ? 160 SER A CA 1 ATOM 1245 C C . SER A 1 160 ? -14.072 -14.003 -22.777 1.00 40.35 ? 160 SER A C 1 ATOM 1246 O O . SER A 1 160 ? -13.739 -14.701 -21.791 1.00 39.81 ? 160 SER A O 1 ATOM 1247 C CB . SER A 1 160 ? -14.136 -11.532 -22.428 1.00 39.77 ? 160 SER A CB 1 ATOM 1248 O OG . SER A 1 160 ? -14.854 -10.588 -21.681 1.00 40.45 ? 160 SER A OG 1 ATOM 1249 N N . PRO A 1 161 ? -13.689 -14.281 -24.034 1.00 40.46 ? 161 PRO A N 1 ATOM 1250 C CA . PRO A 1 161 ? -12.606 -15.235 -24.299 1.00 40.53 ? 161 PRO A CA 1 ATOM 1251 C C . PRO A 1 161 ? -11.305 -14.913 -23.516 1.00 40.11 ? 161 PRO A C 1 ATOM 1252 O O . PRO A 1 161 ? -10.584 -15.842 -23.112 1.00 39.96 ? 161 PRO A O 1 ATOM 1253 C CB . PRO A 1 161 ? -12.425 -15.178 -25.828 1.00 40.53 ? 161 PRO A CB 1 ATOM 1254 C CG . PRO A 1 161 ? -13.265 -14.018 -26.309 1.00 41.17 ? 161 PRO A CG 1 ATOM 1255 C CD . PRO A 1 161 ? -14.322 -13.780 -25.267 1.00 40.48 ? 161 PRO A CD 1 ATOM 1256 N N . VAL A 1 162 ? -11.017 -13.631 -23.291 1.00 39.61 ? 162 VAL A N 1 ATOM 1257 C CA . VAL A 1 162 ? -9.977 -13.272 -22.326 1.00 39.50 ? 162 VAL A CA 1 ATOM 1258 C C . VAL A 1 162 ? -10.502 -12.253 -21.311 1.00 38.81 ? 162 VAL A C 1 ATOM 1259 O O . VAL A 1 162 ? -10.426 -11.042 -21.531 1.00 39.24 ? 162 VAL A O 1 ATOM 1260 C CB . VAL A 1 162 ? -8.605 -12.811 -22.981 1.00 40.47 ? 162 VAL A CB 1 ATOM 1261 C CG1 . VAL A 1 162 ? -7.434 -12.967 -21.951 1.00 39.94 ? 162 VAL A CG1 1 ATOM 1262 C CG2 . VAL A 1 162 ? -8.280 -13.591 -24.301 1.00 40.07 ? 162 VAL A CG2 1 ATOM 1263 N N . PRO A 1 163 ? -11.028 -12.739 -20.177 1.00 38.21 ? 163 PRO A N 1 ATOM 1264 C CA . PRO A 1 163 ? -11.693 -11.821 -19.234 1.00 37.18 ? 163 PRO A CA 1 ATOM 1265 C C . PRO A 1 163 ? -10.715 -11.283 -18.177 1.00 36.45 ? 163 PRO A C 1 ATOM 1266 O O . PRO A 1 163 ? -9.522 -11.495 -18.298 1.00 35.48 ? 163 PRO A O 1 ATOM 1267 C CB . PRO A 1 163 ? -12.751 -12.708 -18.587 1.00 37.09 ? 163 PRO A CB 1 ATOM 1268 C CG . PRO A 1 163 ? -12.181 -14.137 -18.721 1.00 37.80 ? 163 PRO A CG 1 ATOM 1269 C CD . PRO A 1 163 ? -11.016 -14.140 -19.691 1.00 38.00 ? 163 PRO A CD 1 ATOM 1270 N N . THR A 1 164 ? -11.234 -10.588 -17.197 1.00 15.00 ? 164 THR A N 1 ATOM 1271 C CA . THR A 1 164 ? -10.472 -10.006 -16.099 1.00 15.00 ? 164 THR A CA 1 ATOM 1272 C C . THR A 1 164 ? -11.113 -10.334 -14.754 1.00 15.00 ? 164 THR A C 1 ATOM 1273 O O . THR A 1 164 ? -12.314 -10.134 -14.607 1.00 35.92 ? 164 THR A O 1 ATOM 1274 C CB . THR A 1 164 ? -10.049 -8.560 -16.417 1.00 15.00 ? 164 THR A CB 1 ATOM 1275 O OG1 . THR A 1 164 ? -11.120 -7.665 -16.090 1.00 15.00 ? 164 THR A OG1 1 ATOM 1276 C CG2 . THR A 1 164 ? -9.707 -8.418 -17.892 1.00 15.00 ? 164 THR A CG2 1 ATOM 1277 H H . THR A 1 164 ? -12.038 -11.112 -16.997 1.00 15.00 ? 164 THR A H 1 ATOM 1278 H HG1 . THR A 1 164 ? -11.894 -7.887 -16.613 1.00 15.00 ? 164 THR A HG1 1 ATOM 1279 N N . ALA A 1 165 ? -10.333 -10.824 -13.841 1.00 35.16 ? 165 ALA A N 1 ATOM 1280 C CA . ALA A 1 165 ? -10.862 -11.304 -12.577 1.00 34.23 ? 165 ALA A CA 1 ATOM 1281 C C . ALA A 1 165 ? -11.622 -10.216 -11.817 1.00 33.86 ? 165 ALA A C 1 ATOM 1282 O O . ALA A 1 165 ? -11.298 -9.042 -11.886 1.00 33.68 ? 165 ALA A O 1 ATOM 1283 C CB . ALA A 1 165 ? -9.735 -11.887 -11.730 1.00 33.55 ? 165 ALA A CB 1 ATOM 1284 N N . ASP A 1 166 ? -12.649 -10.628 -11.094 1.00 33.40 ? 166 ASP A N 1 ATOM 1285 C CA . ASP A 1 166 ? -13.393 -9.726 -10.236 1.00 32.68 ? 166 ASP A CA 1 ATOM 1286 C C . ASP A 1 166 ? -12.790 -9.744 -8.847 1.00 31.99 ? 166 ASP A C 1 ATOM 1287 O O . ASP A 1 166 ? -12.862 -8.752 -8.121 1.00 32.02 ? 166 ASP A O 1 ATOM 1288 C CB . ASP A 1 166 ? -14.857 -10.141 -10.211 1.00 32.84 ? 166 ASP A CB 1 ATOM 1289 C CG . ASP A 1 166 ? -15.486 -10.041 -11.574 1.00 34.52 ? 166 ASP A CG 1 ATOM 1290 O OD1 . ASP A 1 166 ? -15.595 -8.912 -12.078 1.00 36.50 ? 166 ASP A OD1 1 ATOM 1291 O OD2 . ASP A 1 166 ? -15.841 -11.079 -12.168 1.00 37.48 ? 166 ASP A OD2 1 ATOM 1292 N N . ALA A 1 167 ? -12.167 -10.868 -8.500 1.00 31.01 ? 167 ALA A N 1 ATOM 1293 C CA . ALA A 1 167 ? -11.501 -10.997 -7.216 1.00 30.68 ? 167 ALA A CA 1 ATOM 1294 C C . ALA A 1 167 ? -10.204 -11.795 -7.324 1.00 30.00 ? 167 ALA A C 1 ATOM 1295 O O . ALA A 1 167 ? -9.953 -12.395 -8.341 1.00 30.01 ? 167 ALA A O 1 ATOM 1296 C CB . ALA A 1 167 ? -12.429 -11.607 -6.213 1.00 30.57 ? 167 ALA A CB 1 ATOM 1297 N N . THR A 1 168 ? -9.359 -11.719 -6.305 1.00 29.16 ? 168 THR A N 1 ATOM 1298 C CA . THR A 1 168 ? -8.283 -12.665 -6.117 1.00 28.43 ? 168 THR A CA 1 ATOM 1299 C C . THR A 1 168 ? -8.700 -13.482 -4.900 1.00 28.55 ? 168 THR A C 1 ATOM 1300 O O . THR A 1 168 ? -9.173 -12.919 -3.898 1.00 28.23 ? 168 THR A O 1 ATOM 1301 C CB . THR A 1 168 ? -6.940 -11.952 -5.787 1.00 28.88 ? 168 THR A CB 1 ATOM 1302 O OG1 . THR A 1 168 ? -6.521 -11.148 -6.889 1.00 28.19 ? 168 THR A OG1 1 ATOM 1303 C CG2 . THR A 1 168 ? -5.812 -12.960 -5.441 1.00 28.27 ? 168 THR A CG2 1 ATOM 1304 N N . LEU A 1 169 ? -8.527 -14.793 -4.972 1.00 28.08 ? 169 LEU A N 1 ATOM 1305 C CA . LEU A 1 169 ? -8.764 -15.623 -3.821 1.00 28.14 ? 169 LEU A CA 1 ATOM 1306 C C . LEU A 1 169 ? -7.472 -16.112 -3.195 1.00 28.69 ? 169 LEU A C 1 ATOM 1307 O O . LEU A 1 169 ? -6.587 -16.632 -3.877 1.00 28.32 ? 169 LEU A O 1 ATOM 1308 C CB . LEU A 1 169 ? -9.625 -16.822 -4.162 1.00 27.79 ? 169 LEU A CB 1 ATOM 1309 C CG . LEU A 1 169 ? -10.890 -16.566 -4.961 1.00 29.10 ? 169 LEU A CG 1 ATOM 1310 C CD1 . LEU A 1 169 ? -11.617 -17.890 -5.154 1.00 27.27 ? 169 LEU A CD1 1 ATOM 1311 C CD2 . LEU A 1 169 ? -11.768 -15.462 -4.333 1.00 29.04 ? 169 LEU A CD2 1 ATOM 1312 N N . ILE A 1 170 ? -7.409 -15.957 -1.874 1.00 29.10 ? 170 ILE A N 1 ATOM 1313 C CA . ILE A 1 170 ? -6.320 -16.443 -1.049 1.00 29.32 ? 170 ILE A CA 1 ATOM 1314 C C . ILE A 1 170 ? -6.978 -17.457 -0.117 1.00 30.52 ? 170 ILE A C 1 ATOM 1315 O O . ILE A 1 170 ? -7.958 -17.114 0.540 1.00 29.88 ? 170 ILE A O 1 ATOM 1316 C CB . ILE A 1 170 ? -5.656 -15.262 -0.294 1.00 29.22 ? 170 ILE A CB 1 ATOM 1317 C CG1 . ILE A 1 170 ? -5.318 -14.150 -1.286 1.00 26.38 ? 170 ILE A CG1 1 ATOM 1318 C CG2 . ILE A 1 170 ? -4.422 -15.710 0.476 1.00 28.42 ? 170 ILE A CG2 1 ATOM 1319 C CD1 . ILE A 1 170 ? -4.914 -12.901 -0.674 1.00 24.84 ? 170 ILE A CD1 1 ATOM 1320 N N . ASN A 1 171 ? -6.480 -18.710 -0.118 1.00 31.49 ? 171 ASN A N 1 ATOM 1321 C CA . ASN A 1 171 ? -7.147 -19.867 0.519 1.00 32.27 ? 171 ASN A CA 1 ATOM 1322 C C . ASN A 1 171 ? -8.637 -20.003 0.212 1.00 32.95 ? 171 ASN A C 1 ATOM 1323 O O . ASN A 1 171 ? -9.392 -20.473 1.056 1.00 33.91 ? 171 ASN A O 1 ATOM 1324 C CB . ASN A 1 171 ? -6.963 -19.854 2.047 1.00 32.68 ? 171 ASN A CB 1 ATOM 1325 C CG . ASN A 1 171 ? -5.541 -20.185 2.475 1.00 34.34 ? 171 ASN A CG 1 ATOM 1326 O OD1 . ASN A 1 171 ? -4.810 -20.882 1.770 1.00 38.70 ? 171 ASN A OD1 1 ATOM 1327 N ND2 . ASN A 1 171 ? -5.143 -19.684 3.631 1.00 34.20 ? 171 ASN A ND2 1 ATOM 1328 N N . GLY A 1 172 ? -9.073 -19.591 -0.978 1.00 33.54 ? 172 GLY A N 1 ATOM 1329 C CA . GLY A 1 172 ? -10.486 -19.694 -1.383 1.00 33.74 ? 172 GLY A CA 1 ATOM 1330 C C . GLY A 1 172 ? -11.309 -18.414 -1.200 1.00 34.60 ? 172 GLY A C 1 ATOM 1331 O O . GLY A 1 172 ? -12.399 -18.279 -1.760 1.00 34.86 ? 172 GLY A O 1 ATOM 1332 N N . LEU A 1 173 ? -10.796 -17.472 -0.410 1.00 34.41 ? 173 LEU A N 1 ATOM 1333 C CA . LEU A 1 173 ? -11.571 -16.319 -0.015 1.00 33.75 ? 173 LEU A CA 1 ATOM 1334 C C . LEU A 1 173 ? -10.896 -15.015 -0.453 1.00 34.24 ? 173 LEU A C 1 ATOM 1335 O O . LEU A 1 173 ? -9.657 -14.933 -0.509 1.00 34.44 ? 173 LEU A O 1 ATOM 1336 C CB . LEU A 1 173 ? -11.768 -16.341 1.507 1.00 33.64 ? 173 LEU A CB 1 ATOM 1337 C CG . LEU A 1 173 ? -12.522 -17.501 2.203 1.00 33.29 ? 173 LEU A CG 1 ATOM 1338 C CD1 . LEU A 1 173 ? -12.313 -17.490 3.697 1.00 29.18 ? 173 LEU A CD1 1 ATOM 1339 C CD2 . LEU A 1 173 ? -14.017 -17.487 1.901 1.00 32.64 ? 173 LEU A CD2 1 ATOM 1340 N N . GLY A 1 174 ? -11.716 -14.012 -0.773 1.00 33.66 ? 174 GLY A N 1 ATOM 1341 C CA . GLY A 1 174 ? -11.263 -12.663 -1.039 1.00 33.77 ? 174 GLY A CA 1 ATOM 1342 C C . GLY A 1 174 ? -12.411 -11.803 -1.556 1.00 34.35 ? 174 GLY A C 1 ATOM 1343 O O . GLY A 1 174 ? -13.521 -12.300 -1.737 1.00 35.10 ? 174 GLY A O 1 ATOM 1344 N N . ARG A 1 175 ? -12.136 -10.533 -1.832 1.00 34.01 ? 175 ARG A N 1 ATOM 1345 C CA . ARG A 1 175 ? -13.165 -9.563 -2.055 1.00 34.54 ? 175 ARG A CA 1 ATOM 1346 C C . ARG A 1 175 ? -13.110 -8.968 -3.464 1.00 35.88 ? 175 ARG A C 1 ATOM 1347 O O . ARG A 1 175 ? -12.043 -8.702 -4.013 1.00 36.14 ? 175 ARG A O 1 ATOM 1348 C CB . ARG A 1 175 ? -13.008 -8.432 -1.037 1.00 34.46 ? 175 ARG A CB 1 ATOM 1349 C CG . ARG A 1 175 ? -13.056 -8.870 0.415 1.00 33.39 ? 175 ARG A CG 1 ATOM 1350 C CD . ARG A 1 175 ? -13.006 -7.700 1.343 1.00 32.95 ? 175 ARG A CD 1 ATOM 1351 N NE . ARG A 1 175 ? -13.384 -8.102 2.695 1.00 36.25 ? 175 ARG A NE 1 ATOM 1352 C CZ . ARG A 1 175 ? -13.138 -7.396 3.804 1.00 36.60 ? 175 ARG A CZ 1 ATOM 1353 N NH1 . ARG A 1 175 ? -13.500 -7.870 4.985 1.00 38.30 ? 175 ARG A NH1 1 ATOM 1354 N NH2 . ARG A 1 175 ? -12.497 -6.244 3.753 1.00 36.68 ? 175 ARG A NH2 1 ATOM 1355 N N . SER A 1 176 ? -14.278 -8.735 -4.047 1.00 36.53 ? 176 SER A N 1 ATOM 1356 C CA . SER A 1 176 ? -14.345 -8.000 -5.290 1.00 37.03 ? 176 SER A CA 1 ATOM 1357 C C . SER A 1 176 ? -14.709 -6.556 -4.950 1.00 37.88 ? 176 SER A C 1 ATOM 1358 O O . SER A 1 176 ? -15.042 -6.240 -3.804 1.00 37.67 ? 176 SER A O 1 ATOM 1359 C CB . SER A 1 176 ? -15.399 -8.602 -6.208 1.00 36.52 ? 176 SER A CB 1 ATOM 1360 O OG . SER A 1 176 ? -16.676 -8.151 -5.822 1.00 37.04 ? 176 SER A OG 1 ATOM 1361 N N . ILE A 1 177 ? -14.689 -5.674 -5.935 1.00 38.56 ? 177 ILE A N 1 ATOM 1362 C CA . ILE A 1 177 ? -14.909 -4.304 -5.578 1.00 39.88 ? 177 ILE A CA 1 ATOM 1363 C C . ILE A 1 177 ? -16.364 -4.047 -5.254 1.00 40.28 ? 177 ILE A C 1 ATOM 1364 O O . ILE A 1 177 ? -16.651 -3.015 -4.657 1.00 40.90 ? 177 ILE A O 1 ATOM 1365 C CB . ILE A 1 177 ? -14.360 -3.307 -6.609 1.00 40.09 ? 177 ILE A CB 1 ATOM 1366 C CG1 . ILE A 1 177 ? -15.158 -3.410 -7.925 1.00 40.22 ? 177 ILE A CG1 1 ATOM 1367 C CG2 . ILE A 1 177 ? -12.818 -3.530 -6.753 1.00 40.82 ? 177 ILE A CG2 1 ATOM 1368 C CD1 . ILE A 1 177 ? -14.973 -2.232 -8.869 1.00 39.33 ? 177 ILE A CD1 1 ATOM 1369 N N . ASP A 1 178 ? -17.262 -4.972 -5.626 1.00 40.47 ? 178 ASP A N 1 ATOM 1370 C CA . ASP A 1 178 ? -18.692 -4.844 -5.290 1.00 40.62 ? 178 ASP A CA 1 ATOM 1371 C C . ASP A 1 178 ? -19.026 -5.559 -3.971 1.00 40.56 ? 178 ASP A C 1 ATOM 1372 O O . ASP A 1 178 ? -20.203 -5.650 -3.564 1.00 39.81 ? 178 ASP A O 1 ATOM 1373 C CB . ASP A 1 178 ? -19.607 -5.388 -6.399 1.00 40.89 ? 178 ASP A CB 1 ATOM 1374 C CG . ASP A 1 178 ? -19.231 -4.895 -7.797 1.00 44.14 ? 178 ASP A CG 1 ATOM 1375 O OD1 . ASP A 1 178 ? -19.009 -5.776 -8.693 1.00 46.03 ? 178 ASP A OD1 1 ATOM 1376 O OD2 . ASP A 1 178 ? -19.178 -3.648 -8.004 1.00 43.31 ? 178 ASP A OD2 1 ATOM 1377 N N . THR A 1 179 ? -17.999 -6.099 -3.312 1.00 40.49 ? 179 THR A N 1 ATOM 1378 C CA . THR A 1 179 ? -18.234 -6.970 -2.163 1.00 40.13 ? 179 THR A CA 1 ATOM 1379 C C . THR A 1 179 ? -17.186 -6.735 -1.108 1.00 40.39 ? 179 THR A C 1 ATOM 1380 O O . THR A 1 179 ? -16.548 -7.653 -0.612 1.00 40.66 ? 179 THR A O 1 ATOM 1381 C CB . THR A 1 179 ? -18.265 -8.439 -2.568 1.00 40.02 ? 179 THR A CB 1 ATOM 1382 O OG1 . THR A 1 179 ? -17.121 -8.713 -3.379 1.00 41.48 ? 179 THR A OG1 1 ATOM 1383 C CG2 . THR A 1 179 ? -19.548 -8.786 -3.365 1.00 39.44 ? 179 THR A CG2 1 ATOM 1384 N N . LEU A 1 180 ? -17.047 -5.471 -0.734 1.00 41.13 ? 180 LEU A N 1 ATOM 1385 C CA . LEU A 1 180 ? -16.046 -5.032 0.221 1.00 41.13 ? 180 LEU A CA 1 ATOM 1386 C C . LEU A 1 180 ? -16.308 -5.626 1.608 1.00 41.63 ? 180 LEU A C 1 ATOM 1387 O O . LEU A 1 180 ? -15.561 -5.380 2.557 1.00 42.22 ? 180 LEU A O 1 ATOM 1388 C CB . LEU A 1 180 ? -16.008 -3.497 0.236 1.00 40.98 ? 180 LEU A CB 1 ATOM 1389 C CG . LEU A 1 180 ? -14.999 -2.734 -0.637 1.00 41.23 ? 180 LEU A CG 1 ATOM 1390 C CD1 . LEU A 1 180 ? -14.438 -3.552 -1.802 1.00 39.50 ? 180 LEU A CD1 1 ATOM 1391 C CD2 . LEU A 1 180 ? -15.518 -1.351 -1.105 1.00 40.20 ? 180 LEU A CD2 1 ATOM 1392 N N . ASN A 1 181 ? -17.350 -6.444 1.688 1.00 42.28 ? 181 ASN A N 1 ATOM 1393 C CA . ASN A 1 181 ? -17.850 -7.027 2.932 1.00 43.32 ? 181 ASN A CA 1 ATOM 1394 C C . ASN A 1 181 ? -17.433 -8.474 3.049 1.00 43.00 ? 181 ASN A C 1 ATOM 1395 O O . ASN A 1 181 ? -17.430 -9.033 4.156 1.00 43.57 ? 181 ASN A O 1 ATOM 1396 C CB . ASN A 1 181 ? -19.402 -6.934 3.017 1.00 44.26 ? 181 ASN A CB 1 ATOM 1397 C CG . ASN A 1 181 ? -20.156 -7.445 1.704 1.00 46.80 ? 181 ASN A CG 1 ATOM 1398 O OD1 . ASN A 1 181 ? -19.757 -7.173 0.568 1.00 46.79 ? 181 ASN A OD1 1 ATOM 1399 N ND2 . ASN A 1 181 ? -21.291 -8.131 1.902 1.00 51.76 ? 181 ASN A ND2 1 ATOM 1400 N N . ALA A 1 182 ? -17.081 -9.076 1.908 1.00 42.18 ? 182 ALA A N 1 ATOM 1401 C CA . ALA A 1 182 ? -16.956 -10.533 1.795 1.00 41.05 ? 182 ALA A CA 1 ATOM 1402 C C . ALA A 1 182 ? -15.912 -11.043 2.754 1.00 40.27 ? 182 ALA A C 1 ATOM 1403 O O . ALA A 1 182 ? -15.066 -10.265 3.200 1.00 40.08 ? 182 ALA A O 1 ATOM 1404 C CB . ALA A 1 182 ? -16.623 -10.915 0.392 1.00 41.17 ? 182 ALA A CB 1 ATOM 1405 N N . ASP A 1 183 ? -15.960 -12.327 3.092 1.00 39.32 ? 183 ASP A N 1 ATOM 1406 C CA . ASP A 1 183 ? -15.048 -12.819 4.121 1.00 38.96 ? 183 ASP A CA 1 ATOM 1407 C C . ASP A 1 183 ? -13.586 -12.817 3.650 1.00 37.73 ? 183 ASP A C 1 ATOM 1408 O O . ASP A 1 183 ? -13.292 -12.899 2.455 1.00 36.76 ? 183 ASP A O 1 ATOM 1409 C CB . ASP A 1 183 ? -15.446 -14.206 4.643 1.00 39.60 ? 183 ASP A CB 1 ATOM 1410 C CG . ASP A 1 183 ? -15.072 -14.407 6.132 1.00 43.60 ? 183 ASP A CG 1 ATOM 1411 O OD1 . ASP A 1 183 ? -14.156 -15.173 6.450 1.00 46.86 ? 183 ASP A OD1 1 ATOM 1412 O OD2 . ASP A 1 183 ? -15.691 -13.785 7.030 1.00 52.23 ? 183 ASP A OD2 1 ATOM 1413 N N . LEU A 1 184 ? -12.678 -12.721 4.611 1.00 36.07 ? 184 LEU A N 1 ATOM 1414 C CA . LEU A 1 184 ? -11.272 -12.781 4.323 1.00 34.68 ? 184 LEU A CA 1 ATOM 1415 C C . LEU A 1 184 ? -10.682 -14.034 4.920 1.00 34.03 ? 184 LEU A C 1 ATOM 1416 O O . LEU A 1 184 ? -11.121 -14.489 5.973 1.00 33.11 ? 184 LEU A O 1 ATOM 1417 C CB . LEU A 1 184 ? -10.554 -11.553 4.869 1.00 34.57 ? 184 LEU A CB 1 ATOM 1418 C CG . LEU A 1 184 ? -10.857 -10.268 4.130 1.00 33.67 ? 184 LEU A CG 1 ATOM 1419 C CD1 . LEU A 1 184 ? -10.249 -9.129 4.882 1.00 33.52 ? 184 LEU A CD1 1 ATOM 1420 C CD2 . LEU A 1 184 ? -10.307 -10.348 2.722 1.00 35.04 ? 184 LEU A CD2 1 ATOM 1421 N N . ALA A 1 185 ? -9.694 -14.586 4.216 1.00 33.62 ? 185 ALA A N 1 ATOM 1422 C CA . ALA A 1 185 ? -8.928 -15.713 4.705 1.00 33.46 ? 185 ALA A CA 1 ATOM 1423 C C . ALA A 1 185 ? -8.095 -15.279 5.885 1.00 33.33 ? 185 ALA A C 1 ATOM 1424 O O . ALA A 1 185 ? -7.614 -14.156 5.928 1.00 34.07 ? 185 ALA A O 1 ATOM 1425 C CB . ALA A 1 185 ? -8.045 -16.216 3.636 1.00 33.56 ? 185 ALA A CB 1 ATOM 1426 N N . VAL A 1 186 ? -7.929 -16.165 6.848 1.00 33.08 ? 186 VAL A N 1 ATOM 1427 C CA . VAL A 1 186 ? -7.144 -15.852 8.028 1.00 32.72 ? 186 VAL A CA 1 ATOM 1428 C C . VAL A 1 186 ? -6.151 -16.991 8.236 1.00 33.27 ? 186 VAL A C 1 ATOM 1429 O O . VAL A 1 186 ? -6.537 -18.150 8.394 1.00 32.25 ? 186 VAL A O 1 ATOM 1430 C CB . VAL A 1 186 ? -8.009 -15.671 9.316 1.00 32.48 ? 186 VAL A CB 1 ATOM 1431 C CG1 . VAL A 1 186 ? -7.109 -15.495 10.533 1.00 32.53 ? 186 VAL A CG1 1 ATOM 1432 C CG2 . VAL A 1 186 ? -8.944 -14.474 9.199 1.00 31.76 ? 186 VAL A CG2 1 ATOM 1433 N N . ILE A 1 187 ? -4.871 -16.620 8.225 1.00 33.86 ? 187 ILE A N 1 ATOM 1434 C CA . ILE A 1 187 ? -3.759 -17.515 8.453 1.00 34.03 ? 187 ILE A CA 1 ATOM 1435 C C . ILE A 1 187 ? -3.260 -17.228 9.868 1.00 35.08 ? 187 ILE A C 1 ATOM 1436 O O . ILE A 1 187 ? -2.868 -16.095 10.182 1.00 34.48 ? 187 ILE A O 1 ATOM 1437 C CB . ILE A 1 187 ? -2.679 -17.305 7.380 1.00 33.59 ? 187 ILE A CB 1 ATOM 1438 C CG1 . ILE A 1 187 ? -3.268 -17.626 6.020 1.00 32.33 ? 187 ILE A CG1 1 ATOM 1439 C CG2 . ILE A 1 187 ? -1.498 -18.211 7.611 1.00 33.87 ? 187 ILE A CG2 1 ATOM 1440 C CD1 . ILE A 1 187 ? -2.688 -16.848 4.958 1.00 31.34 ? 187 ILE A CD1 1 ATOM 1441 N N . THR A 1 188 ? -3.324 -18.257 10.721 1.00 36.21 ? 188 THR A N 1 ATOM 1442 C CA . THR A 1 188 ? -3.004 -18.123 12.144 1.00 37.53 ? 188 THR A CA 1 ATOM 1443 C C . THR A 1 188 ? -1.606 -18.629 12.503 1.00 38.28 ? 188 THR A C 1 ATOM 1444 O O . THR A 1 188 ? -1.249 -19.775 12.193 1.00 38.25 ? 188 THR A O 1 ATOM 1445 C CB . THR A 1 188 ? -4.028 -18.864 13.028 1.00 37.48 ? 188 THR A CB 1 ATOM 1446 O OG1 . THR A 1 188 ? -5.316 -18.271 12.864 1.00 38.66 ? 188 THR A OG1 1 ATOM 1447 C CG2 . THR A 1 188 ? -3.649 -18.752 14.492 1.00 37.71 ? 188 THR A CG2 1 ATOM 1448 N N . VAL A 1 189 ? -0.857 -17.773 13.205 1.00 39.18 ? 189 VAL A N 1 ATOM 1449 C CA . VAL A 1 189 ? 0.523 -18.013 13.624 1.00 40.01 ? 189 VAL A CA 1 ATOM 1450 C C . VAL A 1 189 ? 0.686 -17.732 15.143 1.00 40.89 ? 189 VAL A C 1 ATOM 1451 O O . VAL A 1 189 ? -0.018 -16.868 15.694 1.00 41.56 ? 189 VAL A O 1 ATOM 1452 C CB . VAL A 1 189 ? 1.455 -17.111 12.789 1.00 39.78 ? 189 VAL A CB 1 ATOM 1453 C CG1 . VAL A 1 189 ? 2.770 -17.043 13.392 1.00 42.01 ? 189 VAL A CG1 1 ATOM 1454 C CG2 . VAL A 1 189 ? 1.622 -17.645 11.398 1.00 38.99 ? 189 VAL A CG2 1 ATOM 1455 N N . THR A 1 190 ? 1.596 -18.457 15.805 1.00 41.36 ? 190 THR A N 1 ATOM 1456 C CA . THR A 1 190 ? 1.917 -18.305 17.236 1.00 42.11 ? 190 THR A CA 1 ATOM 1457 C C . THR A 1 190 ? 3.264 -17.589 17.348 1.00 42.46 ? 190 THR A C 1 ATOM 1458 O O . THR A 1 190 ? 4.199 -17.952 16.631 1.00 42.47 ? 190 THR A O 1 ATOM 1459 C CB . THR A 1 190 ? 2.073 -19.699 17.917 1.00 42.74 ? 190 THR A CB 1 ATOM 1460 O OG1 . THR A 1 190 ? 0.920 -20.521 17.664 1.00 43.94 ? 190 THR A OG1 1 ATOM 1461 C CG2 . THR A 1 190 ? 2.287 -19.575 19.421 1.00 42.97 ? 190 THR A CG2 1 ATOM 1462 N N . LYS A 1 191 ? 3.399 -16.603 18.242 1.00 42.89 ? 191 LYS A N 1 ATOM 1463 C CA . LYS A 1 191 ? 4.626 -15.783 18.257 1.00 43.04 ? 191 LYS A CA 1 ATOM 1464 C C . LYS A 1 191 ? 5.804 -16.632 18.679 1.00 42.90 ? 191 LYS A C 1 ATOM 1465 O O . LYS A 1 191 ? 5.678 -17.442 19.595 1.00 42.97 ? 191 LYS A O 1 ATOM 1466 C CB . LYS A 1 191 ? 4.512 -14.577 19.188 1.00 43.81 ? 191 LYS A CB 1 ATOM 1467 C CG . LYS A 1 191 ? 5.529 -13.454 18.912 1.00 45.12 ? 191 LYS A CG 1 ATOM 1468 C CD . LYS A 1 191 ? 6.143 -12.913 20.203 1.00 47.48 ? 191 LYS A CD 1 ATOM 1469 C CE . LYS A 1 191 ? 6.727 -11.508 20.019 1.00 47.69 ? 191 LYS A CE 1 ATOM 1470 N NZ . LYS A 1 191 ? 8.001 -11.567 19.254 1.00 48.96 ? 191 LYS A NZ 1 ATOM 1471 N N . GLY A 1 192 ? 6.941 -16.462 18.000 1.00 42.44 ? 192 GLY A N 1 ATOM 1472 C CA . GLY A 1 192 ? 8.121 -17.296 18.254 1.00 41.81 ? 192 GLY A CA 1 ATOM 1473 C C . GLY A 1 192 ? 8.141 -18.680 17.606 1.00 41.68 ? 192 GLY A C 1 ATOM 1474 O O . GLY A 1 192 ? 9.114 -19.425 17.765 1.00 42.37 ? 192 GLY A O 1 ATOM 1475 N N . LYS A 1 193 ? 7.096 -19.046 16.865 1.00 40.80 ? 193 LYS A N 1 ATOM 1476 C CA . LYS A 1 193 ? 7.110 -20.321 16.152 1.00 39.94 ? 193 LYS A CA 1 ATOM 1477 C C . LYS A 1 193 ? 7.625 -20.042 14.713 1.00 38.78 ? 193 LYS A C 1 ATOM 1478 O O . LYS A 1 193 ? 7.581 -18.885 14.239 1.00 38.73 ? 193 LYS A O 1 ATOM 1479 C CB . LYS A 1 193 ? 5.712 -20.991 16.237 1.00 40.56 ? 193 LYS A CB 1 ATOM 1480 C CG . LYS A 1 193 ? 5.634 -22.519 16.620 1.00 41.66 ? 193 LYS A CG 1 ATOM 1481 C CD . LYS A 1 193 ? 5.784 -22.843 18.120 1.00 45.03 ? 193 LYS A CD 1 ATOM 1482 C CE . LYS A 1 193 ? 7.227 -23.421 18.452 1.00 47.68 ? 193 LYS A CE 1 ATOM 1483 N NZ . LYS A 1 193 ? 7.743 -23.370 19.897 1.00 43.48 ? 193 LYS A NZ 1 ATOM 1484 N N . ARG A 1 194 ? 8.153 -21.072 14.046 1.00 37.27 ? 194 ARG A N 1 ATOM 1485 C CA . ARG A 1 194 ? 8.721 -20.922 12.689 1.00 36.16 ? 194 ARG A CA 1 ATOM 1486 C C . ARG A 1 194 ? 7.892 -21.766 11.706 1.00 35.82 ? 194 ARG A C 1 ATOM 1487 O O . ARG A 1 194 ? 7.651 -22.950 11.946 1.00 36.21 ? 194 ARG A O 1 ATOM 1488 C CB . ARG A 1 194 ? 10.231 -21.347 12.632 1.00 36.57 ? 194 ARG A CB 1 ATOM 1489 C CG . ARG A 1 194 ? 11.165 -21.098 13.908 1.00 35.49 ? 194 ARG A CG 1 ATOM 1490 C CD . ARG A 1 194 ? 12.614 -21.607 13.727 1.00 35.31 ? 194 ARG A CD 1 ATOM 1491 N NE . ARG A 1 194 ? 13.075 -21.207 12.383 1.00 45.06 ? 194 ARG A NE 1 ATOM 1492 C CZ . ARG A 1 194 ? 14.325 -21.228 11.841 1.00 45.02 ? 194 ARG A CZ 1 ATOM 1493 N NH1 . ARG A 1 194 ? 15.422 -21.674 12.501 1.00 36.15 ? 194 ARG A NH1 1 ATOM 1494 N NH2 . ARG A 1 194 ? 14.448 -20.794 10.558 1.00 41.62 ? 194 ARG A NH2 1 ATOM 1495 N N . TYR A 1 195 ? 7.488 -21.191 10.583 1.00 34.99 ? 195 TYR A N 1 ATOM 1496 C CA . TYR A 1 195 ? 6.459 -21.811 9.730 1.00 34.29 ? 195 TYR A CA 1 ATOM 1497 C C . TYR A 1 195 ? 6.916 -22.097 8.295 1.00 33.49 ? 195 TYR A C 1 ATOM 1498 O O . TYR A 1 195 ? 7.501 -21.221 7.674 1.00 34.13 ? 195 TYR A O 1 ATOM 1499 C CB . TYR A 1 195 ? 5.243 -20.857 9.670 1.00 34.79 ? 195 TYR A CB 1 ATOM 1500 C CG . TYR A 1 195 ? 4.464 -20.823 10.949 1.00 34.91 ? 195 TYR A CG 1 ATOM 1501 C CD1 . TYR A 1 195 ? 4.740 -19.879 11.940 1.00 36.81 ? 195 TYR A CD1 1 ATOM 1502 C CD2 . TYR A 1 195 ? 3.472 -21.752 11.188 1.00 35.46 ? 195 TYR A CD2 1 ATOM 1503 C CE1 . TYR A 1 195 ? 4.032 -19.870 13.153 1.00 37.30 ? 195 TYR A CE1 1 ATOM 1504 C CE2 . TYR A 1 195 ? 2.756 -21.756 12.380 1.00 37.25 ? 195 TYR A CE2 1 ATOM 1505 C CZ . TYR A 1 195 ? 3.038 -20.818 13.363 1.00 37.84 ? 195 TYR A CZ 1 ATOM 1506 O OH . TYR A 1 195 ? 2.301 -20.838 14.531 1.00 37.09 ? 195 TYR A OH 1 ATOM 1507 N N . ARG A 1 196 ? 6.630 -23.274 7.734 1.00 31.53 ? 196 ARG A N 1 ATOM 1508 C CA . ARG A 1 196 ? 6.867 -23.442 6.296 1.00 29.77 ? 196 ARG A CA 1 ATOM 1509 C C . ARG A 1 196 ? 5.595 -23.225 5.523 1.00 29.95 ? 196 ARG A C 1 ATOM 1510 O O . ARG A 1 196 ? 4.742 -24.111 5.488 1.00 30.40 ? 196 ARG A O 1 ATOM 1511 C CB . ARG A 1 196 ? 7.453 -24.809 5.922 1.00 29.48 ? 196 ARG A CB 1 ATOM 1512 C CG . ARG A 1 196 ? 7.582 -25.005 4.393 1.00 28.87 ? 196 ARG A CG 1 ATOM 1513 C CD . ARG A 1 196 ? 8.093 -26.387 3.989 1.00 27.54 ? 196 ARG A CD 1 ATOM 1514 N NE . ARG A 1 196 ? 8.355 -26.535 2.556 1.00 21.46 ? 196 ARG A NE 1 ATOM 1515 C CZ . ARG A 1 196 ? 9.193 -27.451 2.055 1.00 22.14 ? 196 ARG A CZ 1 ATOM 1516 N NH1 . ARG A 1 196 ? 9.873 -28.253 2.871 1.00 21.60 ? 196 ARG A NH1 1 ATOM 1517 N NH2 . ARG A 1 196 ? 9.379 -27.581 0.745 1.00 18.22 ? 196 ARG A NH2 1 ATOM 1518 N N . PHE A 1 197 ? 5.468 -22.062 4.900 1.00 29.40 ? 197 PHE A N 1 ATOM 1519 C CA . PHE A 1 197 ? 4.337 -21.785 4.032 1.00 29.19 ? 197 PHE A CA 1 ATOM 1520 C C . PHE A 1 197 ? 4.581 -22.186 2.574 1.00 29.10 ? 197 PHE A C 1 ATOM 1521 O O . PHE A 1 197 ? 5.654 -21.913 1.980 1.00 29.04 ? 197 PHE A O 1 ATOM 1522 C CB . PHE A 1 197 ? 3.925 -20.328 4.129 1.00 29.43 ? 197 PHE A CB 1 ATOM 1523 C CG . PHE A 1 197 ? 3.176 -20.028 5.363 1.00 31.29 ? 197 PHE A CG 1 ATOM 1524 C CD1 . PHE A 1 197 ? 3.724 -19.225 6.342 1.00 33.66 ? 197 PHE A CD1 1 ATOM 1525 C CD2 . PHE A 1 197 ? 1.908 -20.579 5.570 1.00 32.49 ? 197 PHE A CD2 1 ATOM 1526 C CE1 . PHE A 1 197 ? 3.023 -18.971 7.513 1.00 34.60 ? 197 PHE A CE1 1 ATOM 1527 C CE2 . PHE A 1 197 ? 1.209 -20.338 6.735 1.00 32.31 ? 197 PHE A CE2 1 ATOM 1528 C CZ . PHE A 1 197 ? 1.755 -19.537 7.707 1.00 32.34 ? 197 PHE A CZ 1 ATOM 1529 N N . ARG A 1 198 ? 3.567 -22.833 2.012 1.00 28.46 ? 198 ARG A N 1 ATOM 1530 C CA . ARG A 1 198 ? 3.640 -23.373 0.673 1.00 28.00 ? 198 ARG A CA 1 ATOM 1531 C C . ARG A 1 198 ? 2.659 -22.631 -0.178 1.00 28.05 ? 198 ARG A C 1 ATOM 1532 O O . ARG A 1 198 ? 1.436 -22.810 -0.041 1.00 27.78 ? 198 ARG A O 1 ATOM 1533 C CB . ARG A 1 198 ? 3.318 -24.846 0.668 1.00 27.54 ? 198 ARG A CB 1 ATOM 1534 C CG . ARG A 1 198 ? 4.386 -25.710 1.264 1.00 28.68 ? 198 ARG A CG 1 ATOM 1535 C CD . ARG A 1 198 ? 3.874 -27.159 1.406 1.00 31.06 ? 198 ARG A CD 1 ATOM 1536 N NE . ARG A 1 198 ? 4.782 -27.960 2.233 1.00 31.26 ? 198 ARG A NE 1 ATOM 1537 C CZ . ARG A 1 198 ? 5.800 -28.654 1.731 1.00 29.85 ? 198 ARG A CZ 1 ATOM 1538 N NH1 . ARG A 1 198 ? 6.611 -29.330 2.554 1.00 25.25 ? 198 ARG A NH1 1 ATOM 1539 N NH2 . ARG A 1 198 ? 5.988 -28.662 0.403 1.00 24.63 ? 198 ARG A NH2 1 ATOM 1540 N N . LEU A 1 199 ? 3.224 -21.814 -1.065 1.00 27.73 ? 199 LEU A N 1 ATOM 1541 C CA . LEU A 1 199 ? 2.486 -20.897 -1.901 1.00 28.07 ? 199 LEU A CA 1 ATOM 1542 C C . LEU A 1 199 ? 2.300 -21.480 -3.289 1.00 27.86 ? 199 LEU A C 1 ATOM 1543 O O . LEU A 1 199 ? 3.271 -21.715 -3.991 1.00 28.37 ? 199 LEU A O 1 ATOM 1544 C CB . LEU A 1 199 ? 3.219 -19.549 -1.972 1.00 28.20 ? 199 LEU A CB 1 ATOM 1545 C CG . LEU A 1 199 ? 2.484 -18.399 -2.648 1.00 30.09 ? 199 LEU A CG 1 ATOM 1546 C CD1 . LEU A 1 199 ? 1.226 -18.061 -1.885 1.00 30.14 ? 199 LEU A CD1 1 ATOM 1547 C CD2 . LEU A 1 199 ? 3.383 -17.194 -2.708 1.00 33.50 ? 199 LEU A CD2 1 ATOM 1548 N N . VAL A 1 200 ? 1.042 -21.691 -3.670 1.00 27.51 ? 200 VAL A N 1 ATOM 1549 C CA . VAL A 1 200 ? 0.639 -22.301 -4.942 1.00 26.83 ? 200 VAL A CA 1 ATOM 1550 C C . VAL A 1 200 ? -0.221 -21.319 -5.721 1.00 26.68 ? 200 VAL A C 1 ATOM 1551 O O . VAL A 1 200 ? -1.222 -20.863 -5.215 1.00 27.19 ? 200 VAL A O 1 ATOM 1552 C CB . VAL A 1 200 ? -0.216 -23.584 -4.702 1.00 26.31 ? 200 VAL A CB 1 ATOM 1553 C CG1 . VAL A 1 200 ? -0.443 -24.330 -5.962 1.00 25.21 ? 200 VAL A CG1 1 ATOM 1554 C CG2 . VAL A 1 200 ? 0.462 -24.478 -3.739 1.00 26.58 ? 200 VAL A CG2 1 ATOM 1555 N N . SER A 1 201 ? 0.144 -21.007 -6.953 1.00 26.90 ? 201 SER A N 1 ATOM 1556 C CA . SER A 1 201 ? -0.718 -20.182 -7.772 1.00 27.60 ? 201 SER A CA 1 ATOM 1557 C C . SER A 1 201 ? -1.641 -21.055 -8.591 1.00 27.68 ? 201 SER A C 1 ATOM 1558 O O . SER A 1 201 ? -1.169 -21.766 -9.494 1.00 28.93 ? 201 SER A O 1 ATOM 1559 C CB . SER A 1 201 ? 0.106 -19.296 -8.678 1.00 27.61 ? 201 SER A CB 1 ATOM 1560 O OG . SER A 1 201 ? -0.736 -18.524 -9.512 1.00 30.46 ? 201 SER A OG 1 ATOM 1561 N N . LEU A 1 202 ? -2.933 -21.013 -8.254 1.00 27.32 ? 202 LEU A N 1 ATOM 1562 C CA . LEU A 1 202 ? -3.994 -21.779 -8.920 1.00 27.64 ? 202 LEU A CA 1 ATOM 1563 C C . LEU A 1 202 ? -4.578 -20.994 -10.086 1.00 28.45 ? 202 LEU A C 1 ATOM 1564 O O . LEU A 1 202 ? -5.662 -21.324 -10.583 1.00 29.01 ? 202 LEU A O 1 ATOM 1565 C CB . LEU A 1 202 ? -5.138 -22.157 -7.941 1.00 26.75 ? 202 LEU A CB 1 ATOM 1566 C CG . LEU A 1 202 ? -4.816 -23.011 -6.688 1.00 25.15 ? 202 LEU A CG 1 ATOM 1567 C CD1 . LEU A 1 202 ? -6.029 -23.292 -5.864 1.00 22.03 ? 202 LEU A CD1 1 ATOM 1568 C CD2 . LEU A 1 202 ? -4.138 -24.318 -7.012 1.00 24.01 ? 202 LEU A CD2 1 ATOM 1569 N N . SER A 1 203 ? -3.846 -19.978 -10.532 1.00 28.57 ? 203 SER A N 1 ATOM 1570 C CA . SER A 1 203 ? -4.379 -18.945 -11.414 1.00 28.68 ? 203 SER A CA 1 ATOM 1571 C C . SER A 1 203 ? -4.541 -19.389 -12.853 1.00 29.33 ? 203 SER A C 1 ATOM 1572 O O . SER A 1 203 ? -3.687 -20.075 -13.406 1.00 29.59 ? 203 SER A O 1 ATOM 1573 C CB . SER A 1 203 ? -3.471 -17.708 -11.359 1.00 28.45 ? 203 SER A CB 1 ATOM 1574 O OG . SER A 1 203 ? -3.997 -16.633 -12.104 1.00 27.66 ? 203 SER A OG 1 ATOM 1575 N N . CYS A 1 204 ? -5.638 -18.963 -13.471 1.00 29.84 ? 204 CYS A N 1 ATOM 1576 C CA . CYS A 1 204 ? -5.832 -19.156 -14.903 1.00 29.62 ? 204 CYS A CA 1 ATOM 1577 C C . CYS A 1 204 ? -5.184 -18.058 -15.716 1.00 29.60 ? 204 CYS A C 1 ATOM 1578 O O . CYS A 1 204 ? -5.070 -18.181 -16.935 1.00 29.59 ? 204 CYS A O 1 ATOM 1579 C CB . CYS A 1 204 ? -7.317 -19.195 -15.240 1.00 29.90 ? 204 CYS A CB 1 ATOM 1580 S SG . CYS A 1 204 ? -7.970 -20.823 -15.204 1.00 30.87 ? 204 CYS A SG 1 ATOM 1581 N N . ASP A 1 205 ? -4.766 -16.971 -15.067 1.00 29.71 ? 205 ASP A N 1 ATOM 1582 C CA . ASP A 1 205 ? -4.229 -15.867 -15.843 1.00 29.79 ? 205 ASP A CA 1 ATOM 1583 C C . ASP A 1 205 ? -3.262 -14.897 -15.123 1.00 30.05 ? 205 ASP A C 1 ATOM 1584 O O . ASP A 1 205 ? -2.075 -14.798 -15.464 1.00 29.39 ? 205 ASP A O 1 ATOM 1585 C CB . ASP A 1 205 ? -5.397 -15.134 -16.494 1.00 29.28 ? 205 ASP A CB 1 ATOM 1586 C CG . ASP A 1 205 ? -4.955 -14.132 -17.494 1.00 30.03 ? 205 ASP A CG 1 ATOM 1587 O OD1 . ASP A 1 205 ? -3.929 -13.472 -17.246 1.00 27.64 ? 205 ASP A OD1 1 ATOM 1588 O OD2 . ASP A 1 205 ? -5.656 -13.983 -18.524 1.00 33.26 ? 205 ASP A OD2 1 ATOM 1589 N N . PRO A 1 206 ? -3.787 -14.096 -14.183 1.00 30.38 ? 206 PRO A N 1 ATOM 1590 C CA . PRO A 1 206 ? -2.840 -13.113 -13.700 1.00 29.70 ? 206 PRO A CA 1 ATOM 1591 C C . PRO A 1 206 ? -1.727 -13.719 -12.843 1.00 29.09 ? 206 PRO A C 1 ATOM 1592 O O . PRO A 1 206 ? -1.946 -14.749 -12.196 1.00 27.16 ? 206 PRO A O 1 ATOM 1593 C CB . PRO A 1 206 ? -3.714 -12.184 -12.865 1.00 30.19 ? 206 PRO A CB 1 ATOM 1594 C CG . PRO A 1 206 ? -4.882 -13.024 -12.451 1.00 30.86 ? 206 PRO A CG 1 ATOM 1595 C CD . PRO A 1 206 ? -5.130 -13.932 -13.586 1.00 29.94 ? 206 PRO A CD 1 ATOM 1596 N N . ASN A 1 207 ? -0.545 -13.077 -12.887 1.00 28.29 ? 207 ASN A N 1 ATOM 1597 C CA . ASN A 1 207 ? 0.474 -13.262 -11.860 1.00 27.25 ? 207 ASN A CA 1 ATOM 1598 C C . ASN A 1 207 ? 0.149 -12.354 -10.682 1.00 26.94 ? 207 ASN A C 1 ATOM 1599 O O . ASN A 1 207 ? -0.696 -11.471 -10.797 1.00 26.91 ? 207 ASN A O 1 ATOM 1600 C CB . ASN A 1 207 ? 1.875 -13.011 -12.397 1.00 27.27 ? 207 ASN A CB 1 ATOM 1601 C CG . ASN A 1 207 ? 2.090 -11.572 -12.895 1.00 28.04 ? 207 ASN A CG 1 ATOM 1602 O OD1 . ASN A 1 207 ? 2.318 -10.685 -12.099 1.00 27.38 ? 207 ASN A OD1 1 ATOM 1603 N ND2 . ASN A 1 207 ? 2.092 -11.366 -14.220 1.00 27.78 ? 207 ASN A ND2 1 ATOM 1604 N N . HIS A 1 208 ? 0.786 -12.601 -9.549 1.00 25.87 ? 208 HIS A N 1 ATOM 1605 C CA . HIS A 1 208 ? 0.526 -11.834 -8.362 1.00 25.57 ? 208 HIS A CA 1 ATOM 1606 C C . HIS A 1 208 ? 1.850 -11.532 -7.623 1.00 25.80 ? 208 HIS A C 1 ATOM 1607 O O . HIS A 1 208 ? 2.696 -12.412 -7.449 1.00 25.41 ? 208 HIS A O 1 ATOM 1608 C CB . HIS A 1 208 ? -0.425 -12.581 -7.405 1.00 25.04 ? 208 HIS A CB 1 ATOM 1609 C CG . HIS A 1 208 ? -1.735 -12.981 -8.007 1.00 23.97 ? 208 HIS A CG 1 ATOM 1610 N ND1 . HIS A 1 208 ? -1.886 -14.119 -8.763 1.00 21.87 ? 208 HIS A ND1 1 ATOM 1611 C CD2 . HIS A 1 208 ? -2.970 -12.426 -7.915 1.00 23.28 ? 208 HIS A CD2 1 ATOM 1612 C CE1 . HIS A 1 208 ? -3.150 -14.234 -9.132 1.00 20.46 ? 208 HIS A CE1 1 ATOM 1613 N NE2 . HIS A 1 208 ? -3.830 -13.228 -8.618 1.00 20.40 ? 208 HIS A NE2 1 ATOM 1614 N N . VAL A 1 209 ? 2.009 -10.289 -7.179 1.00 25.46 ? 209 VAL A N 1 ATOM 1615 C CA . VAL A 1 209 ? 3.108 -9.942 -6.320 1.00 25.25 ? 209 VAL A CA 1 ATOM 1616 C C . VAL A 1 209 ? 2.583 -10.180 -4.925 1.00 25.76 ? 209 VAL A C 1 ATOM 1617 O O . VAL A 1 209 ? 1.583 -9.605 -4.523 1.00 24.25 ? 209 VAL A O 1 ATOM 1618 C CB . VAL A 1 209 ? 3.569 -8.478 -6.594 1.00 25.77 ? 209 VAL A CB 1 ATOM 1619 C CG1 . VAL A 1 209 ? 4.589 -7.996 -5.572 1.00 22.71 ? 209 VAL A CG1 1 ATOM 1620 C CG2 . VAL A 1 209 ? 4.138 -8.385 -8.026 1.00 26.08 ? 209 VAL A CG2 1 ATOM 1621 N N . PHE A 1 210 ? 3.251 -11.076 -4.210 1.00 27.12 ? 210 PHE A N 1 ATOM 1622 C CA . PHE A 1 210 ? 2.788 -11.538 -2.917 1.00 28.85 ? 210 PHE A CA 1 ATOM 1623 C C . PHE A 1 210 ? 3.757 -11.059 -1.884 1.00 29.72 ? 210 PHE A C 1 ATOM 1624 O O . PHE A 1 210 ? 4.957 -11.041 -2.143 1.00 30.82 ? 210 PHE A O 1 ATOM 1625 C CB . PHE A 1 210 ? 2.740 -13.068 -2.902 1.00 29.75 ? 210 PHE A CB 1 ATOM 1626 C CG . PHE A 1 210 ? 2.417 -13.672 -1.545 1.00 30.73 ? 210 PHE A CG 1 ATOM 1627 C CD1 . PHE A 1 210 ? 1.113 -14.056 -1.236 1.00 29.54 ? 210 PHE A CD1 1 ATOM 1628 C CD2 . PHE A 1 210 ? 3.422 -13.884 -0.599 1.00 30.45 ? 210 PHE A CD2 1 ATOM 1629 C CE1 . PHE A 1 210 ? 0.813 -14.626 -0.018 1.00 29.00 ? 210 PHE A CE1 1 ATOM 1630 C CE2 . PHE A 1 210 ? 3.120 -14.450 0.647 1.00 30.38 ? 210 PHE A CE2 1 ATOM 1631 C CZ . PHE A 1 210 ? 1.816 -14.817 0.936 1.00 29.55 ? 210 PHE A CZ 1 ATOM 1632 N N . SER A 1 211 ? 3.244 -10.673 -0.718 1.00 30.07 ? 211 SER A N 1 ATOM 1633 C CA . SER A 1 211 ? 4.034 -9.978 0.306 1.00 30.84 ? 211 SER A CA 1 ATOM 1634 C C . SER A 1 211 ? 3.225 -9.912 1.598 1.00 31.48 ? 211 SER A C 1 ATOM 1635 O O . SER A 1 211 ? 1.990 -9.874 1.560 1.00 32.35 ? 211 SER A O 1 ATOM 1636 C CB . SER A 1 211 ? 4.410 -8.554 -0.148 1.00 30.37 ? 211 SER A CB 1 ATOM 1637 O OG . SER A 1 211 ? 3.279 -7.716 -0.159 1.00 28.49 ? 211 SER A OG 1 ATOM 1638 N N . ILE A 1 212 ? 3.904 -9.912 2.732 1.00 30.99 ? 212 ILE A N 1 ATOM 1639 C CA . ILE A 1 212 ? 3.201 -9.893 3.986 1.00 31.35 ? 212 ILE A CA 1 ATOM 1640 C C . ILE A 1 212 ? 3.721 -8.714 4.769 1.00 32.57 ? 212 ILE A C 1 ATOM 1641 O O . ILE A 1 212 ? 4.932 -8.637 5.060 1.00 32.62 ? 212 ILE A O 1 ATOM 1642 C CB . ILE A 1 212 ? 3.435 -11.150 4.803 1.00 30.72 ? 212 ILE A CB 1 ATOM 1643 C CG1 . ILE A 1 212 ? 2.844 -12.375 4.102 1.00 29.10 ? 212 ILE A CG1 1 ATOM 1644 C CG2 . ILE A 1 212 ? 2.820 -10.964 6.177 1.00 31.35 ? 212 ILE A CG2 1 ATOM 1645 C CD1 . ILE A 1 212 ? 3.188 -13.652 4.759 1.00 22.08 ? 212 ILE A CD1 1 ATOM 1646 N N . ASP A 1 213 ? 2.807 -7.799 5.102 1.00 33.38 ? 213 ASP A N 1 ATOM 1647 C CA . ASP A 1 213 ? 3.143 -6.599 5.829 1.00 34.02 ? 213 ASP A CA 1 ATOM 1648 C C . ASP A 1 213 ? 3.994 -6.965 7.018 1.00 35.18 ? 213 ASP A C 1 ATOM 1649 O O . ASP A 1 213 ? 3.664 -7.894 7.772 1.00 35.72 ? 213 ASP A O 1 ATOM 1650 C CB . ASP A 1 213 ? 1.884 -5.920 6.326 1.00 33.93 ? 213 ASP A CB 1 ATOM 1651 C CG . ASP A 1 213 ? 1.226 -5.035 5.275 1.00 34.92 ? 213 ASP A CG 1 ATOM 1652 O OD1 . ASP A 1 213 ? 1.680 -4.981 4.097 1.00 34.67 ? 213 ASP A OD1 1 ATOM 1653 O OD2 . ASP A 1 213 ? 0.218 -4.395 5.642 1.00 35.18 ? 213 ASP A OD2 1 ATOM 1654 N N . GLY A 1 214 ? 5.118 -6.261 7.163 1.00 35.84 ? 214 GLY A N 1 ATOM 1655 C CA . GLY A 1 214 ? 5.934 -6.352 8.370 1.00 35.72 ? 214 GLY A CA 1 ATOM 1656 C C . GLY A 1 214 ? 6.885 -7.513 8.440 1.00 35.83 ? 214 GLY A C 1 ATOM 1657 O O . GLY A 1 214 ? 7.664 -7.609 9.392 1.00 36.97 ? 214 GLY A O 1 ATOM 1658 N N . HIS A 1 215 ? 6.838 -8.398 7.453 1.00 35.06 ? 215 HIS A N 1 ATOM 1659 C CA . HIS A 1 215 ? 7.596 -9.648 7.531 1.00 34.99 ? 215 HIS A CA 1 ATOM 1660 C C . HIS A 1 215 ? 8.493 -9.841 6.314 1.00 35.35 ? 215 HIS A C 1 ATOM 1661 O O . HIS A 1 215 ? 8.291 -9.229 5.272 1.00 35.94 ? 215 HIS A O 1 ATOM 1662 C CB . HIS A 1 215 ? 6.655 -10.837 7.694 1.00 33.57 ? 215 HIS A CB 1 ATOM 1663 C CG . HIS A 1 215 ? 5.923 -10.850 8.998 1.00 34.29 ? 215 HIS A CG 1 ATOM 1664 N ND1 . HIS A 1 215 ? 4.984 -9.892 9.341 1.00 33.17 ? 215 HIS A ND1 1 ATOM 1665 C CD2 . HIS A 1 215 ? 5.982 -11.711 10.047 1.00 32.41 ? 215 HIS A CD2 1 ATOM 1666 C CE1 . HIS A 1 215 ? 4.495 -10.168 10.537 1.00 30.98 ? 215 HIS A CE1 1 ATOM 1667 N NE2 . HIS A 1 215 ? 5.084 -11.265 10.988 1.00 30.32 ? 215 HIS A NE2 1 ATOM 1668 N N . SER A 1 216 ? 9.489 -10.690 6.455 1.00 35.30 ? 216 SER A N 1 ATOM 1669 C CA . SER A 1 216 ? 10.254 -11.119 5.304 1.00 35.58 ? 216 SER A CA 1 ATOM 1670 C C . SER A 1 216 ? 10.073 -12.611 5.135 1.00 34.62 ? 216 SER A C 1 ATOM 1671 O O . SER A 1 216 ? 9.643 -13.294 6.050 1.00 34.78 ? 216 SER A O 1 ATOM 1672 C CB . SER A 1 216 ? 11.735 -10.748 5.460 1.00 36.28 ? 216 SER A CB 1 ATOM 1673 O OG . SER A 1 216 ? 11.922 -9.370 5.134 1.00 38.01 ? 216 SER A OG 1 ATOM 1674 N N . LEU A 1 217 ? 10.406 -13.106 3.956 1.00 33.58 ? 217 LEU A N 1 ATOM 1675 C CA . LEU A 1 217 ? 10.086 -14.467 3.579 1.00 32.18 ? 217 LEU A CA 1 ATOM 1676 C C . LEU A 1 217 ? 11.361 -15.135 3.093 1.00 31.68 ? 217 LEU A C 1 ATOM 1677 O O . LEU A 1 217 ? 12.047 -14.602 2.213 1.00 31.70 ? 217 LEU A O 1 ATOM 1678 C CB . LEU A 1 217 ? 9.039 -14.457 2.459 1.00 31.48 ? 217 LEU A CB 1 ATOM 1679 C CG . LEU A 1 217 ? 7.917 -13.411 2.511 1.00 31.44 ? 217 LEU A CG 1 ATOM 1680 C CD1 . LEU A 1 217 ? 7.115 -13.416 1.220 1.00 31.91 ? 217 LEU A CD1 1 ATOM 1681 C CD2 . LEU A 1 217 ? 6.995 -13.643 3.674 1.00 30.70 ? 217 LEU A CD2 1 ATOM 1682 N N . THR A 1 218 ? 11.685 -16.292 3.659 1.00 30.75 ? 218 THR A N 1 ATOM 1683 C CA . THR A 1 218 ? 12.871 -17.025 3.231 1.00 30.67 ? 218 THR A CA 1 ATOM 1684 C C . THR A 1 218 ? 12.517 -18.157 2.256 1.00 30.19 ? 218 THR A C 1 ATOM 1685 O O . THR A 1 218 ? 12.065 -19.223 2.687 1.00 30.62 ? 218 THR A O 1 ATOM 1686 C CB . THR A 1 218 ? 13.591 -17.576 4.454 1.00 30.89 ? 218 THR A CB 1 ATOM 1687 O OG1 . THR A 1 218 ? 13.875 -16.497 5.348 1.00 31.63 ? 218 THR A OG1 1 ATOM 1688 C CG2 . THR A 1 218 ? 14.855 -18.315 4.059 1.00 29.23 ? 218 THR A CG2 1 ATOM 1689 N N . VAL A 1 219 ? 12.700 -17.919 0.960 1.00 29.54 ? 219 VAL A N 1 ATOM 1690 C CA . VAL A 1 219 ? 12.259 -18.866 -0.060 1.00 29.72 ? 219 VAL A CA 1 ATOM 1691 C C . VAL A 1 219 ? 13.203 -20.069 -0.112 1.00 30.03 ? 219 VAL A C 1 ATOM 1692 O O . VAL A 1 219 ? 14.441 -19.904 -0.162 1.00 30.83 ? 219 VAL A O 1 ATOM 1693 C CB . VAL A 1 219 ? 12.141 -18.193 -1.462 1.00 30.57 ? 219 VAL A CB 1 ATOM 1694 C CG1 . VAL A 1 219 ? 11.764 -19.209 -2.535 1.00 30.43 ? 219 VAL A CG1 1 ATOM 1695 C CG2 . VAL A 1 219 ? 11.105 -17.064 -1.448 1.00 29.93 ? 219 VAL A CG2 1 ATOM 1696 N N . ILE A 1 220 ? 12.633 -21.272 -0.092 1.00 29.31 ? 220 ILE A N 1 ATOM 1697 C CA . ILE A 1 220 ? 13.423 -22.509 -0.038 1.00 28.75 ? 220 ILE A CA 1 ATOM 1698 C C . ILE A 1 220 ? 13.026 -23.527 -1.139 1.00 29.15 ? 220 ILE A C 1 ATOM 1699 O O . ILE A 1 220 ? 13.642 -24.602 -1.280 1.00 28.51 ? 220 ILE A O 1 ATOM 1700 C CB . ILE A 1 220 ? 13.307 -23.160 1.352 1.00 28.73 ? 220 ILE A CB 1 ATOM 1701 C CG1 . ILE A 1 220 ? 11.843 -23.159 1.823 1.00 28.30 ? 220 ILE A CG1 1 ATOM 1702 C CG2 . ILE A 1 220 ? 14.158 -22.405 2.364 1.00 27.94 ? 220 ILE A CG2 1 ATOM 1703 C CD1 . ILE A 1 220 ? 11.542 -24.119 2.959 1.00 26.09 ? 220 ILE A CD1 1 ATOM 1704 N N . GLU A 1 221 ? 12.021 -23.166 -1.948 1.00 29.09 ? 221 GLU A N 1 ATOM 1705 C CA . GLU A 1 221 ? 11.508 -24.074 -2.976 1.00 28.68 ? 221 GLU A CA 1 ATOM 1706 C C . GLU A 1 221 ? 10.848 -23.333 -4.143 1.00 28.31 ? 221 GLU A C 1 ATOM 1707 O O . GLU A 1 221 ? 10.171 -22.341 -3.955 1.00 29.24 ? 221 GLU A O 1 ATOM 1708 C CB . GLU A 1 221 ? 10.526 -25.053 -2.324 1.00 28.25 ? 221 GLU A CB 1 ATOM 1709 C CG . GLU A 1 221 ? 10.083 -26.167 -3.219 1.00 29.50 ? 221 GLU A CG 1 ATOM 1710 C CD . GLU A 1 221 ? 8.651 -26.613 -2.936 1.00 30.59 ? 221 GLU A CD 1 ATOM 1711 O OE1 . GLU A 1 221 ? 8.094 -26.221 -1.893 1.00 32.42 ? 221 GLU A OE1 1 ATOM 1712 O OE2 . GLU A 1 221 ? 8.084 -27.356 -3.745 1.00 28.59 ? 221 GLU A OE2 1 ATOM 1713 N N . ALA A 1 222 ? 11.047 -23.836 -5.347 1.00 28.27 ? 222 ALA A N 1 ATOM 1714 C CA . ALA A 1 222 ? 10.441 -23.311 -6.561 1.00 27.82 ? 222 ALA A CA 1 ATOM 1715 C C . ALA A 1 222 ? 9.875 -24.503 -7.340 1.00 29.00 ? 222 ALA A C 1 ATOM 1716 O O . ALA A 1 222 ? 10.623 -25.469 -7.656 1.00 28.65 ? 222 ALA A O 1 ATOM 1717 C CB . ALA A 1 222 ? 11.477 -22.619 -7.388 1.00 27.30 ? 222 ALA A CB 1 ATOM 1718 N N . ASP A 1 223 ? 8.561 -24.472 -7.621 1.00 28.99 ? 223 ASP A N 1 ATOM 1719 C CA . ASP A 1 223 ? 7.949 -25.523 -8.434 1.00 29.51 ? 223 ASP A CA 1 ATOM 1720 C C . ASP A 1 223 ? 8.522 -26.906 -8.113 1.00 29.45 ? 223 ASP A C 1 ATOM 1721 O O . ASP A 1 223 ? 8.932 -27.661 -9.018 1.00 28.24 ? 223 ASP A O 1 ATOM 1722 C CB . ASP A 1 223 ? 8.131 -25.246 -9.932 1.00 29.81 ? 223 ASP A CB 1 ATOM 1723 C CG . ASP A 1 223 ? 7.830 -23.844 -10.295 1.00 31.48 ? 223 ASP A CG 1 ATOM 1724 O OD1 . ASP A 1 223 ? 7.239 -23.113 -9.462 1.00 32.48 ? 223 ASP A OD1 1 ATOM 1725 O OD2 . ASP A 1 223 ? 8.184 -23.472 -11.424 1.00 34.94 ? 223 ASP A OD2 1 ATOM 1726 N N . SER A 1 224 ? 8.572 -27.201 -6.810 1.00 29.84 ? 224 SER A N 1 ATOM 1727 C CA . SER A 1 224 ? 8.942 -28.532 -6.296 1.00 29.95 ? 224 SER A CA 1 ATOM 1728 C C . SER A 1 224 ? 10.452 -28.863 -6.409 1.00 29.22 ? 224 SER A C 1 ATOM 1729 O O . SER A 1 224 ? 10.860 -30.046 -6.395 1.00 28.49 ? 224 SER A O 1 ATOM 1730 C CB . SER A 1 224 ? 8.063 -29.635 -6.917 1.00 30.19 ? 224 SER A CB 1 ATOM 1731 O OG . SER A 1 224 ? 8.702 -30.143 -8.082 1.00 34.01 ? 224 SER A OG 1 ATOM 1732 N N . VAL A 1 225 ? 11.268 -27.811 -6.499 1.00 28.44 ? 225 VAL A N 1 ATOM 1733 C CA . VAL A 1 225 ? 12.724 -27.971 -6.535 1.00 28.00 ? 225 VAL A CA 1 ATOM 1734 C C . VAL A 1 225 ? 13.269 -27.312 -5.293 1.00 27.51 ? 225 VAL A C 1 ATOM 1735 O O . VAL A 1 225 ? 12.953 -26.167 -5.040 1.00 28.85 ? 225 VAL A O 1 ATOM 1736 C CB . VAL A 1 225 ? 13.325 -27.356 -7.832 1.00 28.04 ? 225 VAL A CB 1 ATOM 1737 C CG1 . VAL A 1 225 ? 14.846 -27.477 -7.858 1.00 26.96 ? 225 VAL A CG1 1 ATOM 1738 C CG2 . VAL A 1 225 ? 12.721 -28.055 -9.031 1.00 27.52 ? 225 VAL A CG2 1 ATOM 1739 N N . ASN A 1 226 ? 14.029 -28.034 -4.487 1.00 26.88 ? 226 ASN A N 1 ATOM 1740 C CA . ASN A 1 226 ? 14.622 -27.432 -3.315 1.00 27.08 ? 226 ASN A CA 1 ATOM 1741 C C . ASN A 1 226 ? 15.693 -26.378 -3.696 1.00 28.29 ? 226 ASN A C 1 ATOM 1742 O O . ASN A 1 226 ? 16.521 -26.614 -4.604 1.00 28.25 ? 226 ASN A O 1 ATOM 1743 C CB . ASN A 1 226 ? 15.242 -28.493 -2.446 1.00 26.36 ? 226 ASN A CB 1 ATOM 1744 C CG . ASN A 1 226 ? 14.226 -29.349 -1.754 1.00 25.41 ? 226 ASN A CG 1 ATOM 1745 O OD1 . ASN A 1 226 ? 14.500 -30.522 -1.490 1.00 25.87 ? 226 ASN A OD1 1 ATOM 1746 N ND2 . ASN A 1 226 ? 13.065 -28.786 -1.424 1.00 18.48 ? 226 ASN A ND2 1 ATOM 1747 N N . LEU A 1 227 ? 15.661 -25.223 -3.015 1.00 28.95 ? 227 LEU A N 1 ATOM 1748 C CA . LEU A 1 227 ? 16.592 -24.110 -3.305 1.00 29.59 ? 227 LEU A CA 1 ATOM 1749 C C . LEU A 1 227 ? 17.579 -23.888 -2.169 1.00 29.58 ? 227 LEU A C 1 ATOM 1750 O O . LEU A 1 227 ? 17.338 -24.356 -1.056 1.00 29.99 ? 227 LEU A O 1 ATOM 1751 C CB . LEU A 1 227 ? 15.803 -22.830 -3.597 1.00 30.05 ? 227 LEU A CB 1 ATOM 1752 C CG . LEU A 1 227 ? 14.790 -22.918 -4.761 1.00 31.37 ? 227 LEU A CG 1 ATOM 1753 C CD1 . LEU A 1 227 ? 14.026 -21.610 -4.986 1.00 31.33 ? 227 LEU A CD1 1 ATOM 1754 C CD2 . LEU A 1 227 ? 15.527 -23.295 -6.030 1.00 34.39 ? 227 LEU A CD2 1 ATOM 1755 N N . LYS A 1 228 ? 18.723 -23.261 -2.455 1.00 29.68 ? 228 LYS A N 1 ATOM 1756 C CA . LYS A 1 228 ? 19.515 -22.646 -1.397 1.00 29.77 ? 228 LYS A CA 1 ATOM 1757 C C . LYS A 1 228 ? 18.593 -21.531 -0.880 1.00 29.67 ? 228 LYS A C 1 ATOM 1758 O O . LYS A 1 228 ? 17.987 -20.799 -1.678 1.00 28.97 ? 228 LYS A O 1 ATOM 1759 C CB . LYS A 1 228 ? 20.811 -21.976 -1.922 1.00 30.81 ? 228 LYS A CB 1 ATOM 1760 C CG . LYS A 1 228 ? 22.034 -22.840 -2.401 1.00 31.79 ? 228 LYS A CG 1 ATOM 1761 C CD . LYS A 1 228 ? 22.570 -23.811 -1.392 1.00 33.16 ? 228 LYS A CD 1 ATOM 1762 C CE . LYS A 1 228 ? 23.791 -24.559 -1.933 1.00 35.43 ? 228 LYS A CE 1 ATOM 1763 N NZ . LYS A 1 228 ? 25.119 -23.918 -1.563 1.00 40.80 ? 228 LYS A NZ 1 ATOM 1764 N N . PRO A 1 229 ? 18.510 -21.359 0.438 1.00 29.41 ? 229 PRO A N 1 ATOM 1765 C CA . PRO A 1 229 ? 17.556 -20.392 0.918 1.00 30.13 ? 229 PRO A CA 1 ATOM 1766 C C . PRO A 1 229 ? 17.867 -18.990 0.394 1.00 30.40 ? 229 PRO A C 1 ATOM 1767 O O . PRO A 1 229 ? 19.012 -18.630 0.216 1.00 29.53 ? 229 PRO A O 1 ATOM 1768 C CB . PRO A 1 229 ? 17.733 -20.451 2.454 1.00 30.36 ? 229 PRO A CB 1 ATOM 1769 C CG . PRO A 1 229 ? 18.324 -21.809 2.713 1.00 30.08 ? 229 PRO A CG 1 ATOM 1770 C CD . PRO A 1 229 ? 19.264 -21.970 1.538 1.00 29.88 ? 229 PRO A CD 1 ATOM 1771 N N . GLN A 1 230 ? 16.826 -18.202 0.175 1.00 31.28 ? 230 GLN A N 1 ATOM 1772 C CA . GLN A 1 230 ? 16.971 -16.882 -0.434 1.00 31.50 ? 230 GLN A CA 1 ATOM 1773 C C . GLN A 1 230 ? 15.932 -15.968 0.191 1.00 31.24 ? 230 GLN A C 1 ATOM 1774 O O . GLN A 1 230 ? 14.721 -16.186 0.007 1.00 31.59 ? 230 GLN A O 1 ATOM 1775 C CB . GLN A 1 230 ? 16.764 -16.984 -1.939 1.00 31.15 ? 230 GLN A CB 1 ATOM 1776 C CG . GLN A 1 230 ? 16.674 -15.672 -2.604 1.00 32.11 ? 230 GLN A CG 1 ATOM 1777 C CD . GLN A 1 230 ? 17.990 -14.957 -2.530 1.00 35.75 ? 230 GLN A CD 1 ATOM 1778 O OE1 . GLN A 1 230 ? 18.094 -13.871 -1.929 1.00 35.37 ? 230 GLN A OE1 1 ATOM 1779 N NE2 . GLN A 1 230 ? 19.025 -15.562 -3.132 1.00 36.08 ? 230 GLN A NE2 1 ATOM 1780 N N . THR A 1 231 ? 16.390 -14.990 0.971 1.00 31.12 ? 231 THR A N 1 ATOM 1781 C CA . THR A 1 231 ? 15.457 -14.153 1.726 1.00 31.47 ? 231 THR A CA 1 ATOM 1782 C C . THR A 1 231 ? 14.951 -13.028 0.844 1.00 31.34 ? 231 THR A C 1 ATOM 1783 O O . THR A 1 231 ? 15.686 -12.427 0.039 1.00 30.97 ? 231 THR A O 1 ATOM 1784 C CB . THR A 1 231 ? 15.995 -13.682 3.134 1.00 31.89 ? 231 THR A CB 1 ATOM 1785 O OG1 . THR A 1 231 ? 15.742 -14.713 4.091 1.00 33.85 ? 231 THR A OG1 1 ATOM 1786 C CG2 . THR A 1 231 ? 15.285 -12.400 3.656 1.00 31.48 ? 231 THR A CG2 1 ATOM 1787 N N . VAL A 1 232 ? 13.656 -12.794 0.969 1.00 31.16 ? 232 VAL A N 1 ATOM 1788 C CA . VAL A 1 232 ? 12.997 -11.800 0.158 1.00 30.91 ? 232 VAL A CA 1 ATOM 1789 C C . VAL A 1 232 ? 11.915 -11.108 0.961 1.00 30.93 ? 232 VAL A C 1 ATOM 1790 O O . VAL A 1 232 ? 11.664 -11.401 2.153 1.00 30.27 ? 232 VAL A O 1 ATOM 1791 C CB . VAL A 1 232 ? 12.368 -12.419 -1.134 1.00 30.88 ? 232 VAL A CB 1 ATOM 1792 C CG1 . VAL A 1 232 ? 13.432 -13.035 -2.040 1.00 29.65 ? 232 VAL A CG1 1 ATOM 1793 C CG2 . VAL A 1 232 ? 11.284 -13.429 -0.785 1.00 29.44 ? 232 VAL A CG2 1 ATOM 1794 N N . ASP A 1 233 ? 11.179 -10.313 0.216 1.00 30.51 ? 233 ASP A N 1 ATOM 1795 C CA . ASP A 1 233 ? 10.469 -9.189 0.704 1.00 30.68 ? 233 ASP A CA 1 ATOM 1796 C C . ASP A 1 233 ? 9.108 -9.257 0.020 1.00 30.66 ? 233 ASP A C 1 ATOM 1797 O O . ASP A 1 233 ? 8.076 -8.767 0.510 1.00 30.01 ? 233 ASP A O 1 ATOM 1798 C CB . ASP A 1 233 ? 11.074 -7.982 0.080 1.00 31.73 ? 233 ASP A CB 1 ATOM 1799 C CG . ASP A 1 233 ? 10.583 -6.670 0.636 1.00 32.63 ? 233 ASP A CG 1 ATOM 1800 O OD1 . ASP A 1 233 ? 10.772 -6.480 1.849 1.00 38.87 ? 233 ASP A OD1 1 ATOM 1801 O OD2 . ASP A 1 233 ? 10.106 -5.897 -0.192 1.00 32.95 ? 233 ASP A OD2 1 ATOM 1802 N N . SER A 1 234 ? 9.143 -9.844 -1.169 1.00 30.12 ? 234 SER A N 1 ATOM 1803 C CA . SER A 1 234 ? 7.998 -9.895 -2.044 1.00 29.93 ? 234 SER A CA 1 ATOM 1804 C C . SER A 1 234 ? 8.332 -10.908 -3.108 1.00 29.28 ? 234 SER A C 1 ATOM 1805 O O . SER A 1 234 ? 9.494 -11.067 -3.491 1.00 29.55 ? 234 SER A O 1 ATOM 1806 C CB . SER A 1 234 ? 7.720 -8.528 -2.665 1.00 29.78 ? 234 SER A CB 1 ATOM 1807 O OG . SER A 1 234 ? 8.261 -8.427 -3.958 1.00 30.22 ? 234 SER A OG 1 ATOM 1808 N N . ILE A 1 235 ? 7.308 -11.604 -3.563 1.00 28.53 ? 235 ILE A N 1 ATOM 1809 C CA . ILE A 1 235 ? 7.452 -12.612 -4.586 1.00 28.05 ? 235 ILE A CA 1 ATOM 1810 C C . ILE A 1 235 ? 6.410 -12.371 -5.663 1.00 28.30 ? 235 ILE A C 1 ATOM 1811 O O . ILE A 1 235 ? 5.201 -12.357 -5.389 1.00 28.43 ? 235 ILE A O 1 ATOM 1812 C CB . ILE A 1 235 ? 7.210 -14.009 -4.024 1.00 27.98 ? 235 ILE A CB 1 ATOM 1813 C CG1 . ILE A 1 235 ? 8.245 -14.350 -2.940 1.00 26.38 ? 235 ILE A CG1 1 ATOM 1814 C CG2 . ILE A 1 235 ? 7.154 -15.006 -5.182 1.00 26.60 ? 235 ILE A CG2 1 ATOM 1815 C CD1 . ILE A 1 235 ? 7.717 -15.304 -1.898 1.00 23.83 ? 235 ILE A CD1 1 ATOM 1816 N N . GLN A 1 236 ? 6.889 -12.143 -6.878 1.00 28.35 ? 236 GLN A N 1 ATOM 1817 C CA . GLN A 1 236 ? 6.030 -12.062 -8.038 1.00 27.78 ? 236 GLN A CA 1 ATOM 1818 C C . GLN A 1 236 ? 5.930 -13.491 -8.521 1.00 27.50 ? 236 GLN A C 1 ATOM 1819 O O . GLN A 1 236 ? 6.920 -14.064 -9.026 1.00 27.80 ? 236 GLN A O 1 ATOM 1820 C CB . GLN A 1 236 ? 6.619 -11.113 -9.085 1.00 27.65 ? 236 GLN A CB 1 ATOM 1821 C CG . GLN A 1 236 ? 6.142 -11.434 -10.506 1.00 30.34 ? 236 GLN A CG 1 ATOM 1822 C CD . GLN A 1 236 ? 5.906 -10.204 -11.354 1.00 32.09 ? 236 GLN A CD 1 ATOM 1823 O OE1 . GLN A 1 236 ? 4.754 -9.825 -11.608 1.00 32.92 ? 236 GLN A OE1 1 ATOM 1824 N NE2 . GLN A 1 236 ? 6.985 -9.569 -11.792 1.00 30.31 ? 236 GLN A NE2 1 ATOM 1825 N N . ILE A 1 237 ? 4.757 -14.089 -8.308 1.00 26.73 ? 237 ILE A N 1 ATOM 1826 C CA . ILE A 1 237 ? 4.528 -15.504 -8.611 1.00 26.38 ? 237 ILE A CA 1 ATOM 1827 C C . ILE A 1 237 ? 3.598 -15.628 -9.818 1.00 27.10 ? 237 ILE A C 1 ATOM 1828 O O . ILE A 1 237 ? 2.560 -14.964 -9.892 1.00 28.01 ? 237 ILE A O 1 ATOM 1829 C CB . ILE A 1 237 ? 3.984 -16.278 -7.367 1.00 26.81 ? 237 ILE A CB 1 ATOM 1830 C CG1 . ILE A 1 237 ? 3.841 -17.784 -7.634 1.00 26.16 ? 237 ILE A CG1 1 ATOM 1831 C CG2 . ILE A 1 237 ? 2.679 -15.654 -6.845 1.00 24.97 ? 237 ILE A CG2 1 ATOM 1832 C CD1 . ILE A 1 237 ? 3.440 -18.599 -6.418 1.00 25.68 ? 237 ILE A CD1 1 ATOM 1833 N N . PHE A 1 238 ? 3.975 -16.463 -10.776 1.00 27.01 ? 238 PHE A N 1 ATOM 1834 C CA . PHE A 1 238 ? 3.222 -16.577 -12.024 1.00 27.08 ? 238 PHE A CA 1 ATOM 1835 C C . PHE A 1 238 ? 2.244 -17.775 -11.985 1.00 26.27 ? 238 PHE A C 1 ATOM 1836 O O . PHE A 1 238 ? 2.421 -18.710 -11.212 1.00 25.43 ? 238 PHE A O 1 ATOM 1837 C CB . PHE A 1 238 ? 4.195 -16.654 -13.214 1.00 27.28 ? 238 PHE A CB 1 ATOM 1838 C CG . PHE A 1 238 ? 4.988 -15.404 -13.425 1.00 28.16 ? 238 PHE A CG 1 ATOM 1839 C CD1 . PHE A 1 238 ? 4.601 -14.477 -14.390 1.00 29.03 ? 238 PHE A CD1 1 ATOM 1840 C CD2 . PHE A 1 238 ? 6.123 -15.132 -12.655 1.00 30.53 ? 238 PHE A CD2 1 ATOM 1841 C CE1 . PHE A 1 238 ? 5.323 -13.277 -14.578 1.00 27.85 ? 238 PHE A CE1 1 ATOM 1842 C CE2 . PHE A 1 238 ? 6.850 -13.942 -12.845 1.00 29.33 ? 238 PHE A CE2 1 ATOM 1843 C CZ . PHE A 1 238 ? 6.440 -13.020 -13.817 1.00 28.75 ? 238 PHE A CZ 1 ATOM 1844 N N . ALA A 1 239 ? 1.206 -17.725 -12.812 1.00 25.99 ? 239 ALA A N 1 ATOM 1845 C CA . ALA A 1 239 ? 0.192 -18.767 -12.815 1.00 25.07 ? 239 ALA A CA 1 ATOM 1846 C C . ALA A 1 239 ? 0.917 -20.065 -12.820 1.00 24.99 ? 239 ALA A C 1 ATOM 1847 O O . ALA A 1 239 ? 1.843 -20.219 -13.606 1.00 24.45 ? 239 ALA A O 1 ATOM 1848 C CB . ALA A 1 239 ? -0.646 -18.682 -14.038 1.00 24.82 ? 239 ALA A CB 1 ATOM 1849 N N . ALA A 1 240 ? 0.517 -20.974 -11.908 1.00 24.85 ? 240 ALA A N 1 ATOM 1850 C CA . ALA A 1 240 ? 0.956 -22.366 -11.908 1.00 23.98 ? 240 ALA A CA 1 ATOM 1851 C C . ALA A 1 240 ? 2.267 -22.576 -11.147 1.00 23.97 ? 240 ALA A C 1 ATOM 1852 O O . ALA A 1 240 ? 2.621 -23.717 -10.854 1.00 22.89 ? 240 ALA A O 1 ATOM 1853 C CB . ALA A 1 240 ? 1.092 -22.871 -13.324 1.00 23.15 ? 240 ALA A CB 1 ATOM 1854 N N . GLN A 1 241 ? 2.975 -21.487 -10.818 1.00 24.08 ? 241 GLN A N 1 ATOM 1855 C CA . GLN A 1 241 ? 4.179 -21.581 -9.976 1.00 25.10 ? 241 GLN A CA 1 ATOM 1856 C C . GLN A 1 241 ? 3.857 -21.965 -8.532 1.00 25.65 ? 241 GLN A C 1 ATOM 1857 O O . GLN A 1 241 ? 2.704 -21.864 -8.071 1.00 25.86 ? 241 GLN A O 1 ATOM 1858 C CB . GLN A 1 241 ? 5.031 -20.300 -10.041 1.00 24.50 ? 241 GLN A CB 1 ATOM 1859 C CG . GLN A 1 241 ? 5.885 -20.183 -11.326 1.00 24.74 ? 241 GLN A CG 1 ATOM 1860 C CD . GLN A 1 241 ? 6.592 -18.846 -11.485 1.00 26.73 ? 241 GLN A CD 1 ATOM 1861 O OE1 . GLN A 1 241 ? 7.502 -18.695 -12.330 1.00 32.20 ? 241 GLN A OE1 1 ATOM 1862 N NE2 . GLN A 1 241 ? 6.191 -17.867 -10.691 1.00 27.09 ? 241 GLN A NE2 1 ATOM 1863 N N . ARG A 1 242 ? 4.874 -22.443 -7.826 1.00 26.14 ? 242 ARG A N 1 ATOM 1864 C CA . ARG A 1 242 ? 4.791 -22.628 -6.376 1.00 26.38 ? 242 ARG A CA 1 ATOM 1865 C C . ARG A 1 242 ? 6.115 -22.143 -5.748 1.00 27.08 ? 242 ARG A C 1 ATOM 1866 O O . ARG A 1 242 ? 7.202 -22.293 -6.350 1.00 27.66 ? 242 ARG A O 1 ATOM 1867 C CB . ARG A 1 242 ? 4.538 -24.105 -5.974 1.00 25.89 ? 242 ARG A CB 1 ATOM 1868 C CG . ARG A 1 242 ? 3.254 -24.787 -6.464 1.00 25.61 ? 242 ARG A CG 1 ATOM 1869 C CD . ARG A 1 242 ? 3.387 -25.252 -7.902 1.00 26.48 ? 242 ARG A CD 1 ATOM 1870 N NE . ARG A 1 242 ? 4.256 -26.422 -8.069 1.00 26.81 ? 242 ARG A NE 1 ATOM 1871 C CZ . ARG A 1 242 ? 4.870 -26.757 -9.210 1.00 27.90 ? 242 ARG A CZ 1 ATOM 1872 N NH1 . ARG A 1 242 ? 4.754 -25.992 -10.284 1.00 28.36 ? 242 ARG A NH1 1 ATOM 1873 N NH2 . ARG A 1 242 ? 5.636 -27.844 -9.272 1.00 26.36 ? 242 ARG A NH2 1 ATOM 1874 N N . TYR A 1 243 ? 6.017 -21.564 -4.555 1.00 27.01 ? 243 TYR A N 1 ATOM 1875 C CA . TYR A 1 243 ? 7.170 -21.346 -3.696 1.00 26.99 ? 243 TYR A CA 1 ATOM 1876 C C . TYR A 1 243 ? 6.879 -21.829 -2.268 1.00 27.55 ? 243 TYR A C 1 ATOM 1877 O O . TYR A 1 243 ? 5.757 -21.733 -1.779 1.00 27.45 ? 243 TYR A O 1 ATOM 1878 C CB . TYR A 1 243 ? 7.511 -19.867 -3.651 1.00 26.41 ? 243 TYR A CB 1 ATOM 1879 C CG . TYR A 1 243 ? 8.097 -19.339 -4.907 1.00 24.03 ? 243 TYR A CG 1 ATOM 1880 C CD1 . TYR A 1 243 ? 9.427 -19.621 -5.254 1.00 22.17 ? 243 TYR A CD1 1 ATOM 1881 C CD2 . TYR A 1 243 ? 7.349 -18.547 -5.745 1.00 22.81 ? 243 TYR A CD2 1 ATOM 1882 C CE1 . TYR A 1 243 ? 9.999 -19.131 -6.425 1.00 22.14 ? 243 TYR A CE1 1 ATOM 1883 C CE2 . TYR A 1 243 ? 7.891 -18.039 -6.943 1.00 24.86 ? 243 TYR A CE2 1 ATOM 1884 C CZ . TYR A 1 243 ? 9.230 -18.332 -7.276 1.00 26.44 ? 243 TYR A CZ 1 ATOM 1885 O OH . TYR A 1 243 ? 9.784 -17.821 -8.456 1.00 27.37 ? 243 TYR A OH 1 ATOM 1886 N N . SER A 1 244 ? 7.884 -22.383 -1.613 1.00 27.87 ? 244 SER A N 1 ATOM 1887 C CA . SER A 1 244 ? 7.806 -22.582 -0.178 1.00 28.00 ? 244 SER A CA 1 ATOM 1888 C C . SER A 1 244 ? 8.600 -21.408 0.385 1.00 28.38 ? 244 SER A C 1 ATOM 1889 O O . SER A 1 244 ? 9.632 -21.051 -0.180 1.00 28.67 ? 244 SER A O 1 ATOM 1890 C CB . SER A 1 244 ? 8.433 -23.913 0.224 1.00 27.57 ? 244 SER A CB 1 ATOM 1891 O OG . SER A 1 244 ? 7.511 -24.970 0.060 1.00 27.55 ? 244 SER A OG 1 ATOM 1892 N N . PHE A 1 245 ? 8.115 -20.782 1.447 1.00 28.25 ? 245 PHE A N 1 ATOM 1893 C CA . PHE A 1 245 ? 8.926 -19.797 2.138 1.00 28.74 ? 245 PHE A CA 1 ATOM 1894 C C . PHE A 1 245 ? 8.758 -20.005 3.629 1.00 29.05 ? 245 PHE A C 1 ATOM 1895 O O . PHE A 1 245 ? 7.693 -20.409 4.086 1.00 28.76 ? 245 PHE A O 1 ATOM 1896 C CB . PHE A 1 245 ? 8.595 -18.344 1.696 1.00 29.05 ? 245 PHE A CB 1 ATOM 1897 C CG . PHE A 1 245 ? 7.232 -17.861 2.126 1.00 28.56 ? 245 PHE A CG 1 ATOM 1898 C CD1 . PHE A 1 245 ? 7.001 -17.441 3.437 1.00 29.52 ? 245 PHE A CD1 1 ATOM 1899 C CD2 . PHE A 1 245 ? 6.185 -17.834 1.223 1.00 28.20 ? 245 PHE A CD2 1 ATOM 1900 C CE1 . PHE A 1 245 ? 5.715 -17.002 3.841 1.00 31.42 ? 245 PHE A CE1 1 ATOM 1901 C CE2 . PHE A 1 245 ? 4.918 -17.412 1.586 1.00 28.79 ? 245 PHE A CE2 1 ATOM 1902 C CZ . PHE A 1 245 ? 4.673 -16.982 2.908 1.00 31.48 ? 245 PHE A CZ 1 ATOM 1903 N N . VAL A 1 246 ? 9.825 -19.776 4.376 1.00 29.92 ? 246 VAL A N 1 ATOM 1904 C CA . VAL A 1 246 ? 9.788 -19.930 5.824 1.00 30.59 ? 246 VAL A CA 1 ATOM 1905 C C . VAL A 1 246 ? 9.455 -18.575 6.395 1.00 31.41 ? 246 VAL A C 1 ATOM 1906 O O . VAL A 1 246 ? 10.047 -17.563 5.998 1.00 32.36 ? 246 VAL A O 1 ATOM 1907 C CB . VAL A 1 246 ? 11.156 -20.361 6.382 1.00 30.60 ? 246 VAL A CB 1 ATOM 1908 C CG1 . VAL A 1 246 ? 11.152 -20.343 7.922 1.00 30.90 ? 246 VAL A CG1 1 ATOM 1909 C CG2 . VAL A 1 246 ? 11.498 -21.727 5.886 1.00 30.45 ? 246 VAL A CG2 1 ATOM 1910 N N . LEU A 1 247 ? 8.496 -18.529 7.304 1.00 32.44 ? 247 LEU A N 1 ATOM 1911 C CA . LEU A 1 247 ? 8.176 -17.278 7.963 1.00 33.16 ? 247 LEU A CA 1 ATOM 1912 C C . LEU A 1 247 ? 8.415 -17.476 9.431 1.00 34.75 ? 247 LEU A C 1 ATOM 1913 O O . LEU A 1 247 ? 7.987 -18.469 10.016 1.00 34.65 ? 247 LEU A O 1 ATOM 1914 C CB . LEU A 1 247 ? 6.741 -16.833 7.671 1.00 32.00 ? 247 LEU A CB 1 ATOM 1915 C CG . LEU A 1 247 ? 6.333 -15.535 8.368 1.00 30.38 ? 247 LEU A CG 1 ATOM 1916 C CD1 . LEU A 1 247 ? 5.425 -14.725 7.481 1.00 27.69 ? 247 LEU A CD1 1 ATOM 1917 C CD2 . LEU A 1 247 ? 5.707 -15.775 9.767 1.00 25.29 ? 247 LEU A CD2 1 ATOM 1918 N N . ASN A 1 248 ? 9.143 -16.541 10.017 1.00 37.38 ? 248 ASN A N 1 ATOM 1919 C CA . ASN A 1 248 ? 9.387 -16.572 11.435 1.00 39.72 ? 248 ASN A CA 1 ATOM 1920 C C . ASN A 1 248 ? 8.473 -15.564 12.071 1.00 39.95 ? 248 ASN A C 1 ATOM 1921 O O . ASN A 1 248 ? 8.591 -14.366 11.827 1.00 40.11 ? 248 ASN A O 1 ATOM 1922 C CB . ASN A 1 248 ? 10.834 -16.224 11.728 1.00 40.43 ? 248 ASN A CB 1 ATOM 1923 C CG . ASN A 1 248 ? 11.146 -16.137 13.263 1.00 46.05 ? 248 ASN A CG 1 ATOM 1924 O OD1 . ASN A 1 248 ? 10.409 -16.683 14.144 1.00 46.70 ? 248 ASN A OD1 1 ATOM 1925 N ND2 . ASN A 1 248 ? 12.275 -15.442 13.580 1.00 49.93 ? 248 ASN A ND2 1 ATOM 1926 N N . ALA A 1 249 ? 7.563 -16.050 12.900 1.00 40.82 ? 249 ALA A N 1 ATOM 1927 C CA . ALA A 1 249 ? 6.564 -15.169 13.517 1.00 41.42 ? 249 ALA A CA 1 ATOM 1928 C C . ALA A 1 249 ? 7.189 -14.544 14.745 1.00 41.95 ? 249 ALA A C 1 ATOM 1929 O O . ALA A 1 249 ? 7.084 -15.075 15.868 1.00 41.56 ? 249 ALA A O 1 ATOM 1930 C CB . ALA A 1 249 ? 5.319 -15.960 13.879 1.00 41.13 ? 249 ALA A CB 1 ATOM 1931 N N . ASP A 1 250 ? 7.893 -13.444 14.511 1.00 42.96 ? 250 ASP A N 1 ATOM 1932 C CA . ASP A 1 250 ? 8.740 -12.840 15.536 1.00 43.89 ? 250 ASP A CA 1 ATOM 1933 C C . ASP A 1 250 ? 8.543 -11.357 15.570 1.00 44.63 ? 250 ASP A C 1 ATOM 1934 O O . ASP A 1 250 ? 9.471 -10.613 15.878 1.00 45.58 ? 250 ASP A O 1 ATOM 1935 C CB . ASP A 1 250 ? 10.229 -13.198 15.336 1.00 44.15 ? 250 ASP A CB 1 ATOM 1936 C CG . ASP A 1 250 ? 10.873 -12.544 14.094 1.00 44.17 ? 250 ASP A CG 1 ATOM 1937 O OD1 . ASP A 1 250 ? 10.207 -11.854 13.296 1.00 44.78 ? 250 ASP A OD1 1 ATOM 1938 O OD2 . ASP A 1 250 ? 12.093 -12.738 13.922 1.00 45.20 ? 250 ASP A OD2 1 ATOM 1939 N N . GLN A 1 251 ? 7.332 -10.938 15.234 1.00 44.97 ? 251 GLN A N 1 ATOM 1940 C CA . GLN A 1 251 ? 6.965 -9.542 15.193 1.00 45.54 ? 251 GLN A CA 1 ATOM 1941 C C . GLN A 1 251 ? 5.958 -9.325 16.293 1.00 45.87 ? 251 GLN A C 1 ATOM 1942 O O . GLN A 1 251 ? 5.581 -10.278 16.984 1.00 45.76 ? 251 GLN A O 1 ATOM 1943 C CB . GLN A 1 251 ? 6.347 -9.209 13.832 1.00 45.82 ? 251 GLN A CB 1 ATOM 1944 C CG . GLN A 1 251 ? 7.322 -9.328 12.668 1.00 46.30 ? 251 GLN A CG 1 ATOM 1945 C CD . GLN A 1 251 ? 8.591 -8.523 12.892 1.00 45.77 ? 251 GLN A CD 1 ATOM 1946 O OE1 . GLN A 1 251 ? 8.547 -7.291 13.043 1.00 45.94 ? 251 GLN A OE1 1 ATOM 1947 N NE2 . GLN A 1 251 ? 9.727 -9.212 12.915 1.00 43.60 ? 251 GLN A NE2 1 ATOM 1948 N N . ASP A 1 252 ? 5.520 -8.079 16.462 1.00 46.43 ? 252 ASP A N 1 ATOM 1949 C CA . ASP A 1 252 ? 4.500 -7.758 17.471 1.00 47.06 ? 252 ASP A CA 1 ATOM 1950 C C . ASP A 1 252 ? 3.150 -8.461 17.240 1.00 46.61 ? 252 ASP A C 1 ATOM 1951 O O . ASP A 1 252 ? 2.478 -8.191 16.223 1.00 47.31 ? 252 ASP A O 1 ATOM 1952 C CB . ASP A 1 252 ? 4.290 -6.241 17.550 1.00 47.39 ? 252 ASP A CB 1 ATOM 1953 C CG . ASP A 1 252 ? 5.384 -5.556 18.317 1.00 49.58 ? 252 ASP A CG 1 ATOM 1954 O OD1 . ASP A 1 252 ? 6.018 -6.233 19.172 1.00 49.90 ? 252 ASP A OD1 1 ATOM 1955 O OD2 . ASP A 1 252 ? 5.618 -4.349 18.054 1.00 52.62 ? 252 ASP A OD2 1 ATOM 1956 N N . VAL A 1 253 ? 2.756 -9.341 18.171 1.00 45.18 ? 253 VAL A N 1 ATOM 1957 C CA . VAL A 1 253 ? 1.400 -9.919 18.181 1.00 43.47 ? 253 VAL A CA 1 ATOM 1958 C C . VAL A 1 253 ? 0.448 -8.884 17.593 1.00 42.72 ? 253 VAL A C 1 ATOM 1959 O O . VAL A 1 253 ? 0.437 -7.747 18.018 1.00 42.64 ? 253 VAL A O 1 ATOM 1960 C CB . VAL A 1 253 ? 0.941 -10.300 19.610 1.00 43.16 ? 253 VAL A CB 1 ATOM 1961 C CG1 . VAL A 1 253 ? -0.534 -10.625 19.628 1.00 41.49 ? 253 VAL A CG1 1 ATOM 1962 C CG2 . VAL A 1 253 ? 1.782 -11.468 20.171 1.00 42.79 ? 253 VAL A CG2 1 ATOM 1963 N N . GLY A 1 254 ? -0.304 -9.254 16.571 1.00 42.04 ? 254 GLY A N 1 ATOM 1964 C CA . GLY A 1 254 ? -1.063 -8.252 15.825 1.00 41.17 ? 254 GLY A CA 1 ATOM 1965 C C . GLY A 1 254 ? -1.659 -8.887 14.601 1.00 40.19 ? 254 GLY A C 1 ATOM 1966 O O . GLY A 1 254 ? -1.508 -10.101 14.389 1.00 40.14 ? 254 GLY A O 1 ATOM 1967 N N . ASN A 1 255 ? -2.353 -8.069 13.817 1.00 39.18 ? 255 ASN A N 1 ATOM 1968 C CA . ASN A 1 255 ? -2.845 -8.477 12.513 1.00 38.48 ? 255 ASN A CA 1 ATOM 1969 C C . ASN A 1 255 ? -2.134 -7.750 11.395 1.00 37.77 ? 255 ASN A C 1 ATOM 1970 O O . ASN A 1 255 ? -2.118 -6.521 11.354 1.00 37.93 ? 255 ASN A O 1 ATOM 1971 C CB . ASN A 1 255 ? -4.347 -8.272 12.403 1.00 38.51 ? 255 ASN A CB 1 ATOM 1972 C CG . ASN A 1 255 ? -5.098 -8.993 13.494 1.00 41.04 ? 255 ASN A CG 1 ATOM 1973 O OD1 . ASN A 1 255 ? -5.359 -10.223 13.430 1.00 40.99 ? 255 ASN A OD1 1 ATOM 1974 N ND2 . ASN A 1 255 ? -5.422 -8.244 14.538 1.00 43.32 ? 255 ASN A ND2 1 ATOM 1975 N N . TYR A 1 256 ? -1.541 -8.519 10.486 1.00 36.90 ? 256 TYR A N 1 ATOM 1976 C CA . TYR A 1 256 ? -0.838 -7.948 9.339 1.00 35.88 ? 256 TYR A CA 1 ATOM 1977 C C . TYR A 1 256 ? -1.508 -8.374 8.049 1.00 34.70 ? 256 TYR A C 1 ATOM 1978 O O . TYR A 1 256 ? -1.931 -9.517 7.917 1.00 34.49 ? 256 TYR A O 1 ATOM 1979 C CB . TYR A 1 256 ? 0.613 -8.428 9.313 1.00 35.27 ? 256 TYR A CB 1 ATOM 1980 C CG . TYR A 1 256 ? 1.372 -8.169 10.586 1.00 36.18 ? 256 TYR A CG 1 ATOM 1981 C CD1 . TYR A 1 256 ? 1.143 -8.927 11.727 1.00 34.58 ? 256 TYR A CD1 1 ATOM 1982 C CD2 . TYR A 1 256 ? 2.329 -7.154 10.653 1.00 37.81 ? 256 TYR A CD2 1 ATOM 1983 C CE1 . TYR A 1 256 ? 1.836 -8.684 12.874 1.00 34.10 ? 256 TYR A CE1 1 ATOM 1984 C CE2 . TYR A 1 256 ? 3.045 -6.919 11.816 1.00 35.18 ? 256 TYR A CE2 1 ATOM 1985 C CZ . TYR A 1 256 ? 2.795 -7.693 12.910 1.00 34.14 ? 256 TYR A CZ 1 ATOM 1986 O OH . TYR A 1 256 ? 3.502 -7.458 14.059 1.00 35.25 ? 256 TYR A OH 1 ATOM 1987 N N . TRP A 1 257 ? -1.572 -7.459 7.092 1.00 33.80 ? 257 TRP A N 1 ATOM 1988 C CA . TRP A 1 257 ? -2.046 -7.793 5.754 1.00 33.26 ? 257 TRP A CA 1 ATOM 1989 C C . TRP A 1 257 ? -1.150 -8.776 4.961 1.00 32.43 ? 257 TRP A C 1 ATOM 1990 O O . TRP A 1 257 ? 0.081 -8.657 4.919 1.00 32.60 ? 257 TRP A O 1 ATOM 1991 C CB . TRP A 1 257 ? -2.248 -6.535 4.925 1.00 33.26 ? 257 TRP A CB 1 ATOM 1992 C CG . TRP A 1 257 ? -3.449 -5.686 5.275 1.00 34.44 ? 257 TRP A CG 1 ATOM 1993 C CD1 . TRP A 1 257 ? -3.431 -4.375 5.687 1.00 34.21 ? 257 TRP A CD1 1 ATOM 1994 C CD2 . TRP A 1 257 ? -4.841 -6.061 5.195 1.00 34.68 ? 257 TRP A CD2 1 ATOM 1995 N NE1 . TRP A 1 257 ? -4.712 -3.918 5.851 1.00 35.42 ? 257 TRP A NE1 1 ATOM 1996 C CE2 . TRP A 1 257 ? -5.598 -4.929 5.572 1.00 34.91 ? 257 TRP A CE2 1 ATOM 1997 C CE3 . TRP A 1 257 ? -5.517 -7.245 4.849 1.00 33.99 ? 257 TRP A CE3 1 ATOM 1998 C CZ2 . TRP A 1 257 ? -6.990 -4.939 5.611 1.00 33.36 ? 257 TRP A CZ2 1 ATOM 1999 C CZ3 . TRP A 1 257 ? -6.898 -7.253 4.879 1.00 34.36 ? 257 TRP A CZ3 1 ATOM 2000 C CH2 . TRP A 1 257 ? -7.622 -6.106 5.270 1.00 33.99 ? 257 TRP A CH2 1 ATOM 2001 N N . ILE A 1 258 ? -1.800 -9.741 4.330 1.00 31.29 ? 258 ILE A N 1 ATOM 2002 C CA . ILE A 1 258 ? -1.189 -10.582 3.310 1.00 29.85 ? 258 ILE A CA 1 ATOM 2003 C C . ILE A 1 258 ? -1.716 -10.090 1.996 1.00 30.23 ? 258 ILE A C 1 ATOM 2004 O O . ILE A 1 258 ? -2.919 -9.930 1.831 1.00 30.72 ? 258 ILE A O 1 ATOM 2005 C CB . ILE A 1 258 ? -1.579 -12.040 3.467 1.00 28.98 ? 258 ILE A CB 1 ATOM 2006 C CG1 . ILE A 1 258 ? -1.033 -12.571 4.792 1.00 25.41 ? 258 ILE A CG1 1 ATOM 2007 C CG2 . ILE A 1 258 ? -1.084 -12.829 2.261 1.00 27.79 ? 258 ILE A CG2 1 ATOM 2008 C CD1 . ILE A 1 258 ? -1.506 -13.877 5.119 1.00 21.61 ? 258 ILE A CD1 1 ATOM 2009 N N . ARG A 1 259 ? -0.812 -9.814 1.070 1.00 30.96 ? 259 ARG A N 1 ATOM 2010 C CA . ARG A 1 259 ? -1.170 -9.111 -0.165 1.00 31.66 ? 259 ARG A CA 1 ATOM 2011 C C . ARG A 1 259 ? -0.825 -9.976 -1.400 1.00 30.92 ? 259 ARG A C 1 ATOM 2012 O O . ARG A 1 259 ? 0.195 -10.654 -1.427 1.00 30.81 ? 259 ARG A O 1 ATOM 2013 C CB . ARG A 1 259 ? -0.536 -7.692 -0.193 1.00 30.92 ? 259 ARG A CB 1 ATOM 2014 C CG . ARG A 1 259 ? -0.616 -6.982 1.151 1.00 30.96 ? 259 ARG A CG 1 ATOM 2015 C CD . ARG A 1 259 ? 0.155 -5.627 1.272 1.00 33.84 ? 259 ARG A CD 1 ATOM 2016 N NE . ARG A 1 259 ? -0.773 -4.492 1.204 1.00 39.45 ? 259 ARG A NE 1 ATOM 2017 C CZ . ARG A 1 259 ? -1.136 -3.734 2.238 1.00 40.16 ? 259 ARG A CZ 1 ATOM 2018 N NH1 . ARG A 1 259 ? -2.027 -2.775 2.066 1.00 40.97 ? 259 ARG A NH1 1 ATOM 2019 N NH2 . ARG A 1 259 ? -0.621 -3.918 3.442 1.00 39.27 ? 259 ARG A NH2 1 ATOM 2020 N N . ALA A 1 260 ? -1.723 -9.992 -2.382 1.00 30.50 ? 260 ALA A N 1 ATOM 2021 C CA . ALA A 1 260 ? -1.441 -10.605 -3.666 1.00 29.69 ? 260 ALA A CA 1 ATOM 2022 C C . ALA A 1 260 ? -1.953 -9.651 -4.733 1.00 29.69 ? 260 ALA A C 1 ATOM 2023 O O . ALA A 1 260 ? -3.124 -9.727 -5.150 1.00 29.62 ? 260 ALA A O 1 ATOM 2024 C CB . ALA A 1 260 ? -2.095 -11.975 -3.781 1.00 29.46 ? 260 ALA A CB 1 ATOM 2025 N N . LEU A 1 261 ? -1.088 -8.724 -5.150 1.00 29.32 ? 261 LEU A N 1 ATOM 2026 C CA . LEU A 1 261 ? -1.465 -7.726 -6.161 1.00 29.48 ? 261 LEU A CA 1 ATOM 2027 C C . LEU A 1 261 ? -1.472 -8.381 -7.518 1.00 29.34 ? 261 LEU A C 1 ATOM 2028 O O . LEU A 1 261 ? -0.461 -8.866 -7.953 1.00 29.69 ? 261 LEU A O 1 ATOM 2029 C CB . LEU A 1 261 ? -0.479 -6.540 -6.185 1.00 29.90 ? 261 LEU A CB 1 ATOM 2030 C CG . LEU A 1 261 ? -0.811 -5.376 -7.135 1.00 29.13 ? 261 LEU A CG 1 ATOM 2031 C CD1 . LEU A 1 261 ? -2.156 -4.766 -6.717 1.00 25.27 ? 261 LEU A CD1 1 ATOM 2032 C CD2 . LEU A 1 261 ? 0.271 -4.299 -7.135 1.00 28.50 ? 261 LEU A CD2 1 ATOM 2033 N N . PRO A 1 262 ? -2.621 -8.423 -8.184 1.00 29.93 ? 262 PRO A N 1 ATOM 2034 C CA . PRO A 1 262 ? -2.592 -9.011 -9.520 1.00 29.92 ? 262 PRO A CA 1 ATOM 2035 C C . PRO A 1 262 ? -2.002 -8.024 -10.538 1.00 30.22 ? 262 PRO A C 1 ATOM 2036 O O . PRO A 1 262 ? -1.887 -6.838 -10.240 1.00 30.36 ? 262 PRO A O 1 ATOM 2037 C CB . PRO A 1 262 ? -4.068 -9.269 -9.801 1.00 30.06 ? 262 PRO A CB 1 ATOM 2038 C CG . PRO A 1 262 ? -4.786 -8.156 -9.063 1.00 28.96 ? 262 PRO A CG 1 ATOM 2039 C CD . PRO A 1 262 ? -3.973 -7.968 -7.799 1.00 29.75 ? 262 PRO A CD 1 ATOM 2040 N N . ASN A 1 263 ? -1.636 -8.521 -11.720 1.00 31.13 ? 263 ASN A N 1 ATOM 2041 C CA . ASN A 1 263 ? -1.148 -7.701 -12.843 1.00 31.56 ? 263 ASN A CA 1 ATOM 2042 C C . ASN A 1 263 ? -2.260 -7.245 -13.736 1.00 32.32 ? 263 ASN A C 1 ATOM 2043 O O . ASN A 1 263 ? -1.996 -6.612 -14.745 1.00 33.30 ? 263 ASN A O 1 ATOM 2044 C CB . ASN A 1 263 ? -0.140 -8.486 -13.703 1.00 31.20 ? 263 ASN A CB 1 ATOM 2045 C CG . ASN A 1 263 ? -0.758 -9.743 -14.333 1.00 31.43 ? 263 ASN A CG 1 ATOM 2046 O OD1 . ASN A 1 263 ? -1.502 -10.465 -13.655 1.00 32.01 ? 263 ASN A OD1 1 ATOM 2047 N ND2 . ASN A 1 263 ? -0.447 -10.019 -15.619 1.00 25.48 ? 263 ASN A ND2 1 ATOM 2048 N N . SER A 1 264 ? -3.496 -7.613 -13.419 1.00 33.35 ? 264 SER A N 1 ATOM 2049 C CA . SER A 1 264 ? -4.669 -7.116 -14.160 1.00 34.42 ? 264 SER A CA 1 ATOM 2050 C C . SER A 1 264 ? -5.926 -7.126 -13.292 1.00 35.46 ? 264 SER A C 1 ATOM 2051 O O . SER A 1 264 ? -5.891 -7.624 -12.163 1.00 35.57 ? 264 SER A O 1 ATOM 2052 C CB . SER A 1 264 ? -4.911 -7.876 -15.476 1.00 33.99 ? 264 SER A CB 1 ATOM 2053 O OG . SER A 1 264 ? -5.137 -9.240 -15.250 1.00 32.40 ? 264 SER A OG 1 ATOM 2054 N N . GLY A 1 265 ? -7.021 -6.585 -13.833 1.00 36.22 ? 265 GLY A N 1 ATOM 2055 C CA . GLY A 1 265 ? -8.217 -6.323 -13.058 1.00 37.75 ? 265 GLY A CA 1 ATOM 2056 C C . GLY A 1 265 ? -7.908 -5.278 -12.011 1.00 39.03 ? 265 GLY A C 1 ATOM 2057 O O . GLY A 1 265 ? -7.190 -4.318 -12.287 1.00 38.71 ? 265 GLY A O 1 ATOM 2058 N N . THR A 1 266 ? -8.405 -5.506 -10.794 1.00 41.00 ? 266 THR A N 1 ATOM 2059 C CA . THR A 1 266 ? -8.301 -4.550 -9.687 1.00 42.77 ? 266 THR A CA 1 ATOM 2060 C C . THR A 1 266 ? -6.896 -4.440 -9.069 1.00 43.79 ? 266 THR A C 1 ATOM 2061 O O . THR A 1 266 ? -6.462 -5.295 -8.290 1.00 43.77 ? 266 THR A O 1 ATOM 2062 C CB . THR A 1 266 ? -9.390 -4.808 -8.634 1.00 42.57 ? 266 THR A CB 1 ATOM 2063 O OG1 . THR A 1 266 ? -10.664 -4.744 -9.279 1.00 44.01 ? 266 THR A OG1 1 ATOM 2064 C CG2 . THR A 1 266 ? -9.363 -3.737 -7.544 1.00 43.11 ? 266 THR A CG2 1 ATOM 2065 N N . ARG A 1 267 ? -6.193 -3.371 -9.432 1.00 45.40 ? 267 ARG A N 1 ATOM 2066 C CA . ARG A 1 267 ? -4.839 -3.150 -8.943 1.00 47.13 ? 267 ARG A CA 1 ATOM 2067 C C . ARG A 1 267 ? -4.936 -2.386 -7.631 1.00 47.97 ? 267 ARG A C 1 ATOM 2068 O O . ARG A 1 267 ? -6.016 -2.030 -7.191 1.00 49.54 ? 267 ARG A O 1 ATOM 2069 C CB . ARG A 1 267 ? -3.981 -2.461 -10.002 1.00 47.02 ? 267 ARG A CB 1 ATOM 2070 C CG . ARG A 1 267 ? -4.057 -3.152 -11.370 1.00 48.58 ? 267 ARG A CG 1 ATOM 2071 C CD . ARG A 1 267 ? -2.920 -4.100 -11.588 1.00 52.55 ? 267 ARG A CD 1 ATOM 2072 N NE . ARG A 1 267 ? -1.714 -3.391 -12.033 1.00 55.62 ? 267 ARG A NE 1 ATOM 2073 C CZ . ARG A 1 267 ? -0.459 -3.726 -11.716 1.00 57.00 ? 267 ARG A CZ 1 ATOM 2074 N NH1 . ARG A 1 267 ? 0.541 -2.995 -12.175 1.00 58.34 ? 267 ARG A NH1 1 ATOM 2075 N NH2 . ARG A 1 267 ? -0.182 -4.774 -10.939 1.00 56.93 ? 267 ARG A NH2 1 ATOM 2076 N N . ASN A 1 268 ? -3.837 -2.154 -6.960 1.00 48.71 ? 268 ASN A N 1 ATOM 2077 C CA . ASN A 1 268 ? -3.944 -1.732 -5.548 1.00 49.14 ? 268 ASN A CA 1 ATOM 2078 C C . ASN A 1 268 ? -5.067 -2.407 -4.676 1.00 47.39 ? 268 ASN A C 1 ATOM 2079 O O . ASN A 1 268 ? -5.766 -3.296 -5.161 1.00 46.48 ? 268 ASN A O 1 ATOM 2080 C CB . ASN A 1 268 ? -3.820 -0.184 -5.427 1.00 50.98 ? 268 ASN A CB 1 ATOM 2081 C CG . ASN A 1 268 ? -2.306 0.330 -5.587 1.00 54.08 ? 268 ASN A CG 1 ATOM 2082 O OD1 . ASN A 1 268 ? -1.400 -0.040 -4.801 1.00 55.58 ? 268 ASN A OD1 1 ATOM 2083 N ND2 . ASN A 1 268 ? -2.067 1.170 -6.612 1.00 55.48 ? 268 ASN A ND2 1 ATOM 2084 N N . PHE A 1 269 ? -5.179 -2.029 -3.391 1.00 45.91 ? 269 PHE A N 1 ATOM 2085 C CA . PHE A 1 269 ? -5.879 -2.830 -2.364 1.00 43.90 ? 269 PHE A CA 1 ATOM 2086 C C . PHE A 1 269 ? -7.032 -2.135 -1.613 1.00 43.58 ? 269 PHE A C 1 ATOM 2087 O O . PHE A 1 269 ? -7.225 -2.378 -0.415 1.00 43.15 ? 269 PHE A O 1 ATOM 2088 C CB . PHE A 1 269 ? -4.879 -3.280 -1.287 1.00 43.21 ? 269 PHE A CB 1 ATOM 2089 C CG . PHE A 1 269 ? -3.699 -4.035 -1.813 1.00 42.68 ? 269 PHE A CG 1 ATOM 2090 C CD1 . PHE A 1 269 ? -3.732 -5.422 -1.909 1.00 39.46 ? 269 PHE A CD1 1 ATOM 2091 C CD2 . PHE A 1 269 ? -2.528 -3.359 -2.194 1.00 41.45 ? 269 PHE A CD2 1 ATOM 2092 C CE1 . PHE A 1 269 ? -2.637 -6.108 -2.397 1.00 38.82 ? 269 PHE A CE1 1 ATOM 2093 C CE2 . PHE A 1 269 ? -1.426 -4.056 -2.671 1.00 39.26 ? 269 PHE A CE2 1 ATOM 2094 C CZ . PHE A 1 269 ? -1.484 -5.422 -2.780 1.00 40.21 ? 269 PHE A CZ 1 ATOM 2095 N N . ASP A 1 270 ? -7.804 -1.273 -2.258 1.00 42.95 ? 270 ASP A N 1 ATOM 2096 C CA . ASP A 1 270 ? -8.786 -0.517 -1.453 1.00 42.30 ? 270 ASP A CA 1 ATOM 2097 C C . ASP A 1 270 ? -9.888 -1.427 -0.890 1.00 41.50 ? 270 ASP A C 1 ATOM 2098 O O . ASP A 1 270 ? -10.473 -2.199 -1.645 1.00 41.57 ? 270 ASP A O 1 ATOM 2099 C CB . ASP A 1 270 ? -9.356 0.658 -2.244 1.00 41.87 ? 270 ASP A CB 1 ATOM 2100 C CG . ASP A 1 270 ? -8.271 1.611 -2.732 1.00 42.86 ? 270 ASP A CG 1 ATOM 2101 O OD1 . ASP A 1 270 ? -8.536 2.339 -3.702 1.00 44.18 ? 270 ASP A OD1 1 ATOM 2102 O OD2 . ASP A 1 270 ? -7.147 1.628 -2.173 1.00 42.89 ? 270 ASP A OD2 1 ATOM 2103 N N . GLY A 1 271 ? -10.125 -1.368 0.424 1.00 40.29 ? 271 GLY A N 1 ATOM 2104 C CA . GLY A 1 271 ? -11.188 -2.158 1.066 1.00 39.44 ? 271 GLY A CA 1 ATOM 2105 C C . GLY A 1 271 ? -10.859 -3.627 1.391 1.00 38.95 ? 271 GLY A C 1 ATOM 2106 O O . GLY A 1 271 ? -11.759 -4.461 1.656 1.00 38.78 ? 271 GLY A O 1 ATOM 2107 N N . GLY A 1 272 ? -9.571 -3.945 1.366 1.00 37.75 ? 272 GLY A N 1 ATOM 2108 C CA . GLY A 1 272 ? -9.106 -5.304 1.540 1.00 36.65 ? 272 GLY A CA 1 ATOM 2109 C C . GLY A 1 272 ? -9.314 -6.213 0.346 1.00 36.22 ? 272 GLY A C 1 ATOM 2110 O O . GLY A 1 272 ? -9.332 -7.435 0.505 1.00 36.65 ? 272 GLY A O 1 ATOM 2111 N N . VAL A 1 273 ? -9.482 -5.657 -0.849 1.00 35.37 ? 273 VAL A N 1 ATOM 2112 C CA . VAL A 1 273 ? -9.368 -6.507 -2.014 1.00 35.78 ? 273 VAL A CA 1 ATOM 2113 C C . VAL A 1 273 ? -7.943 -7.009 -2.139 1.00 35.04 ? 273 VAL A C 1 ATOM 2114 O O . VAL A 1 273 ? -7.001 -6.396 -1.605 1.00 35.18 ? 273 VAL A O 1 ATOM 2115 C CB . VAL A 1 273 ? -9.805 -5.859 -3.348 1.00 36.13 ? 273 VAL A CB 1 ATOM 2116 C CG1 . VAL A 1 273 ? -11.303 -5.489 -3.302 1.00 35.81 ? 273 VAL A CG1 1 ATOM 2117 C CG2 . VAL A 1 273 ? -8.925 -4.689 -3.672 1.00 37.81 ? 273 VAL A CG2 1 ATOM 2118 N N . ASN A 1 274 ? -7.798 -8.132 -2.845 1.00 33.83 ? 274 ASN A N 1 ATOM 2119 C CA . ASN A 1 274 ? -6.496 -8.741 -3.086 1.00 32.29 ? 274 ASN A CA 1 ATOM 2120 C C . ASN A 1 274 ? -5.786 -8.965 -1.777 1.00 31.70 ? 274 ASN A C 1 ATOM 2121 O O . ASN A 1 274 ? -4.573 -8.761 -1.679 1.00 32.23 ? 274 ASN A O 1 ATOM 2122 C CB . ASN A 1 274 ? -5.647 -7.875 -4.030 1.00 31.70 ? 274 ASN A CB 1 ATOM 2123 C CG . ASN A 1 274 ? -6.279 -7.712 -5.394 1.00 32.38 ? 274 ASN A CG 1 ATOM 2124 O OD1 . ASN A 1 274 ? -6.749 -8.681 -5.990 1.00 34.23 ? 274 ASN A OD1 1 ATOM 2125 N ND2 . ASN A 1 274 ? -6.299 -6.490 -5.900 1.00 31.30 ? 274 ASN A ND2 1 ATOM 2126 N N . SER A 1 275 ? -6.538 -9.406 -0.771 1.00 30.91 ? 275 SER A N 1 ATOM 2127 C CA . SER A 1 275 ? -6.023 -9.419 0.608 1.00 30.64 ? 275 SER A CA 1 ATOM 2128 C C . SER A 1 275 ? -6.495 -10.574 1.458 1.00 30.54 ? 275 SER A C 1 ATOM 2129 O O . SER A 1 275 ? -7.597 -11.140 1.241 1.00 30.61 ? 275 SER A O 1 ATOM 2130 C CB . SER A 1 275 ? -6.360 -8.104 1.339 1.00 29.97 ? 275 SER A CB 1 ATOM 2131 O OG . SER A 1 275 ? -5.691 -7.011 0.740 1.00 30.20 ? 275 SER A OG 1 ATOM 2132 N N . ALA A 1 276 ? -5.631 -10.909 2.416 1.00 29.75 ? 276 ALA A N 1 ATOM 2133 C CA . ALA A 1 276 ? -5.946 -11.802 3.516 1.00 29.96 ? 276 ALA A CA 1 ATOM 2134 C C . ALA A 1 276 ? -5.174 -11.335 4.743 1.00 30.11 ? 276 ALA A C 1 ATOM 2135 O O . ALA A 1 276 ? -4.527 -10.294 4.722 1.00 30.43 ? 276 ALA A O 1 ATOM 2136 C CB . ALA A 1 276 ? -5.626 -13.279 3.176 1.00 29.98 ? 276 ALA A CB 1 ATOM 2137 N N . ILE A 1 277 ? -5.247 -12.121 5.804 1.00 30.24 ? 277 ILE A N 1 ATOM 2138 C CA . ILE A 1 277 ? -4.872 -11.701 7.123 1.00 30.18 ? 277 ILE A CA 1 ATOM 2139 C C . ILE A 1 277 ? -3.959 -12.725 7.756 1.00 30.18 ? 277 ILE A C 1 ATOM 2140 O O . ILE A 1 277 ? -4.359 -13.853 7.942 1.00 29.25 ? 277 ILE A O 1 ATOM 2141 C CB . ILE A 1 277 ? -6.133 -11.625 8.013 1.00 30.24 ? 277 ILE A CB 1 ATOM 2142 C CG1 . ILE A 1 277 ? -7.128 -10.583 7.486 1.00 30.20 ? 277 ILE A CG1 1 ATOM 2143 C CG2 . ILE A 1 277 ? -5.760 -11.412 9.494 1.00 30.07 ? 277 ILE A CG2 1 ATOM 2144 C CD1 . ILE A 1 277 ? -8.445 -10.533 8.289 1.00 30.81 ? 277 ILE A CD1 1 ATOM 2145 N N . LEU A 1 278 ? -2.736 -12.308 8.072 1.00 31.37 ? 278 LEU A N 1 ATOM 2146 C CA . LEU A 1 278 ? -1.908 -12.961 9.073 1.00 32.98 ? 278 LEU A CA 1 ATOM 2147 C C . LEU A 1 278 ? -2.269 -12.478 10.499 1.00 34.02 ? 278 LEU A C 1 ATOM 2148 O O . LEU A 1 278 ? -2.255 -11.264 10.798 1.00 33.34 ? 278 LEU A O 1 ATOM 2149 C CB . LEU A 1 278 ? -0.431 -12.708 8.796 1.00 33.08 ? 278 LEU A CB 1 ATOM 2150 C CG . LEU A 1 278 ? 0.521 -13.660 9.525 1.00 33.68 ? 278 LEU A CG 1 ATOM 2151 C CD1 . LEU A 1 278 ? 0.369 -15.054 8.962 1.00 32.13 ? 278 LEU A CD1 1 ATOM 2152 C CD2 . LEU A 1 278 ? 1.971 -13.174 9.358 1.00 35.55 ? 278 LEU A CD2 1 ATOM 2153 N N . ARG A 1 279 ? -2.602 -13.440 11.362 1.00 35.50 ? 279 ARG A N 1 ATOM 2154 C CA . ARG A 1 279 ? -3.078 -13.150 12.720 1.00 37.18 ? 279 ARG A CA 1 ATOM 2155 C C . ARG A 1 279 ? -2.271 -13.938 13.732 1.00 38.02 ? 279 ARG A C 1 ATOM 2156 O O . ARG A 1 279 ? -2.343 -15.159 13.738 1.00 38.16 ? 279 ARG A O 1 ATOM 2157 C CB . ARG A 1 279 ? -4.566 -13.521 12.848 1.00 37.10 ? 279 ARG A CB 1 ATOM 2158 C CG . ARG A 1 279 ? -5.150 -13.328 14.261 1.00 37.68 ? 279 ARG A CG 1 ATOM 2159 C CD . ARG A 1 279 ? -6.666 -13.239 14.243 1.00 36.14 ? 279 ARG A CD 1 ATOM 2160 N NE . ARG A 1 279 ? -7.104 -12.087 13.466 1.00 35.82 ? 279 ARG A NE 1 ATOM 2161 C CZ . ARG A 1 279 ? -8.274 -11.986 12.832 1.00 36.15 ? 279 ARG A CZ 1 ATOM 2162 N NH1 . ARG A 1 279 ? -8.556 -10.870 12.138 1.00 36.16 ? 279 ARG A NH1 1 ATOM 2163 N NH2 . ARG A 1 279 ? -9.157 -12.981 12.875 1.00 33.52 ? 279 ARG A NH2 1 ATOM 2164 N N . TYR A 1 280 ? -1.499 -13.246 14.574 1.00 39.71 ? 280 TYR A N 1 ATOM 2165 C CA . TYR A 1 280 ? -0.820 -13.897 15.711 1.00 41.43 ? 280 TYR A CA 1 ATOM 2166 C C . TYR A 1 280 ? -1.850 -14.352 16.732 1.00 42.99 ? 280 TYR A C 1 ATOM 2167 O O . TYR A 1 280 ? -2.857 -13.653 16.936 1.00 42.60 ? 280 TYR A O 1 ATOM 2168 C CB . TYR A 1 280 ? 0.154 -12.935 16.391 1.00 40.97 ? 280 TYR A CB 1 ATOM 2169 C CG . TYR A 1 280 ? 1.472 -12.786 15.670 1.00 41.03 ? 280 TYR A CG 1 ATOM 2170 C CD1 . TYR A 1 280 ? 1.552 -12.115 14.442 1.00 41.14 ? 280 TYR A CD1 1 ATOM 2171 C CD2 . TYR A 1 280 ? 2.638 -13.302 16.209 1.00 40.50 ? 280 TYR A CD2 1 ATOM 2172 C CE1 . TYR A 1 280 ? 2.743 -11.962 13.782 1.00 39.05 ? 280 TYR A CE1 1 ATOM 2173 C CE2 . TYR A 1 280 ? 3.849 -13.160 15.555 1.00 39.89 ? 280 TYR A CE2 1 ATOM 2174 C CZ . TYR A 1 280 ? 3.892 -12.491 14.334 1.00 40.97 ? 280 TYR A CZ 1 ATOM 2175 O OH . TYR A 1 280 ? 5.098 -12.359 13.658 1.00 42.21 ? 280 TYR A OH 1 ATOM 2176 N N . ASP A 1 281 ? -1.630 -15.515 17.358 1.00 44.67 ? 281 ASP A N 1 ATOM 2177 C CA . ASP A 1 281 ? -2.444 -15.884 18.530 1.00 47.35 ? 281 ASP A CA 1 ATOM 2178 C C . ASP A 1 281 ? -2.466 -14.730 19.574 1.00 47.80 ? 281 ASP A C 1 ATOM 2179 O O . ASP A 1 281 ? -1.406 -14.182 19.932 1.00 47.79 ? 281 ASP A O 1 ATOM 2180 C CB . ASP A 1 281 ? -1.937 -17.162 19.219 1.00 48.19 ? 281 ASP A CB 1 ATOM 2181 C CG . ASP A 1 281 ? -1.885 -18.363 18.291 1.00 51.58 ? 281 ASP A CG 1 ATOM 2182 O OD1 . ASP A 1 281 ? -1.431 -19.447 18.753 1.00 54.41 ? 281 ASP A OD1 1 ATOM 2183 O OD2 . ASP A 1 281 ? -2.280 -18.225 17.109 1.00 55.09 ? 281 ASP A OD2 1 ATOM 2184 N N . GLY A 1 282 ? -3.660 -14.376 20.051 1.00 47.76 ? 282 GLY A N 1 ATOM 2185 C CA . GLY A 1 282 ? -3.788 -13.360 21.079 1.00 47.90 ? 282 GLY A CA 1 ATOM 2186 C C . GLY A 1 282 ? -4.080 -11.982 20.526 1.00 48.17 ? 282 GLY A C 1 ATOM 2187 O O . GLY A 1 282 ? -4.404 -11.065 21.284 1.00 48.66 ? 282 GLY A O 1 ATOM 2188 N N . ALA A 1 283 ? -3.964 -11.820 19.211 1.00 47.98 ? 283 ALA A N 1 ATOM 2189 C CA . ALA A 1 283 ? -4.322 -10.557 18.572 1.00 47.96 ? 283 ALA A CA 1 ATOM 2190 C C . ALA A 1 283 ? -5.836 -10.472 18.470 1.00 47.96 ? 283 ALA A C 1 ATOM 2191 O O . ALA A 1 283 ? -6.528 -11.501 18.373 1.00 47.76 ? 283 ALA A O 1 ATOM 2192 C CB . ALA A 1 283 ? -3.682 -10.434 17.196 1.00 47.64 ? 283 ALA A CB 1 ATOM 2193 N N . ALA A 1 284 ? -6.345 -9.242 18.487 1.00 47.83 ? 284 ALA A N 1 ATOM 2194 C CA . ALA A 1 284 ? -7.782 -9.017 18.430 1.00 48.00 ? 284 ALA A CA 1 ATOM 2195 C C . ALA A 1 284 ? -8.364 -9.512 17.095 1.00 47.94 ? 284 ALA A C 1 ATOM 2196 O O . ALA A 1 284 ? -7.703 -9.410 16.066 1.00 48.02 ? 284 ALA A O 1 ATOM 2197 C CB . ALA A 1 284 ? -8.094 -7.542 18.663 1.00 47.73 ? 284 ALA A CB 1 ATOM 2198 N N . PRO A 1 285 ? -9.585 -10.080 17.115 1.00 47.87 ? 285 PRO A N 1 ATOM 2199 C CA . PRO A 1 285 ? -10.324 -10.501 15.896 1.00 47.40 ? 285 PRO A CA 1 ATOM 2200 C C . PRO A 1 285 ? -10.684 -9.376 14.912 1.00 46.79 ? 285 PRO A C 1 ATOM 2201 O O . PRO A 1 285 ? -11.854 -9.227 14.518 1.00 46.63 ? 285 PRO A O 1 ATOM 2202 C CB . PRO A 1 285 ? -11.620 -11.124 16.460 1.00 48.13 ? 285 PRO A CB 1 ATOM 2203 C CG . PRO A 1 285 ? -11.725 -10.637 17.882 1.00 48.47 ? 285 PRO A CG 1 ATOM 2204 C CD . PRO A 1 285 ? -10.315 -10.420 18.353 1.00 47.66 ? 285 PRO A CD 1 ATOM 2205 N N . VAL A 1 286 ? -9.691 -8.610 14.488 1.00 46.09 ? 286 VAL A N 1 ATOM 2206 C CA . VAL A 1 286 ? -9.958 -7.449 13.642 1.00 45.64 ? 286 VAL A CA 1 ATOM 2207 C C . VAL A 1 286 ? -9.129 -7.472 12.384 1.00 45.35 ? 286 VAL A C 1 ATOM 2208 O O . VAL A 1 286 ? -8.141 -8.193 12.307 1.00 45.38 ? 286 VAL A O 1 ATOM 2209 C CB . VAL A 1 286 ? -9.741 -6.096 14.394 1.00 45.71 ? 286 VAL A CB 1 ATOM 2210 C CG1 . VAL A 1 286 ? -10.991 -5.717 15.204 1.00 45.50 ? 286 VAL A CG1 1 ATOM 2211 C CG2 . VAL A 1 286 ? -8.491 -6.138 15.268 1.00 44.38 ? 286 VAL A CG2 1 ATOM 2212 N N . GLU A 1 287 ? -9.566 -6.694 11.394 1.00 15.00 ? 287 GLU A N 1 ATOM 2213 C CA . GLU A 1 287 ? -8.797 -6.500 10.171 1.00 15.00 ? 287 GLU A CA 1 ATOM 2214 C C . GLU A 1 287 ? -7.491 -5.765 10.456 1.00 15.00 ? 287 GLU A C 1 ATOM 2215 O O . GLU A 1 287 ? -7.505 -4.904 11.337 1.00 46.29 ? 287 GLU A O 1 ATOM 2216 C CB . GLU A 1 287 ? -9.620 -5.716 9.146 1.00 15.00 ? 287 GLU A CB 1 ATOM 2217 C CG . GLU A 1 287 ? -10.617 -6.562 8.371 1.00 15.00 ? 287 GLU A CG 1 ATOM 2218 C CD . GLU A 1 287 ? -11.447 -5.745 7.402 1.00 15.00 ? 287 GLU A CD 1 ATOM 2219 O OE1 . GLU A 1 287 ? -12.692 -5.824 7.469 1.00 15.00 ? 287 GLU A OE1 1 ATOM 2220 O OE2 . GLU A 1 287 ? -10.855 -5.025 6.570 1.00 15.00 ? 287 GLU A OE2 1 ATOM 2221 H H . GLU A 1 287 ? -9.199 -6.376 12.246 1.00 15.00 ? 287 GLU A H 1 ATOM 2222 N N . PRO A 1 288 ? -6.402 -6.099 9.746 1.00 46.91 ? 288 PRO A N 1 ATOM 2223 C CA . PRO A 1 288 ? -5.120 -5.403 9.917 1.00 46.82 ? 288 PRO A CA 1 ATOM 2224 C C . PRO A 1 288 ? -5.191 -3.925 9.553 1.00 46.95 ? 288 PRO A C 1 ATOM 2225 O O . PRO A 1 288 ? -6.024 -3.492 8.770 1.00 46.73 ? 288 PRO A O 1 ATOM 2226 C CB . PRO A 1 288 ? -4.185 -6.130 8.948 1.00 46.46 ? 288 PRO A CB 1 ATOM 2227 C CG . PRO A 1 288 ? -4.823 -7.456 8.740 1.00 47.41 ? 288 PRO A CG 1 ATOM 2228 C CD . PRO A 1 288 ? -6.288 -7.171 8.740 1.00 46.98 ? 288 PRO A CD 1 ATOM 2229 N N . THR A 1 289 ? -4.289 -3.158 10.133 1.00 47.76 ? 289 THR A N 1 ATOM 2230 C CA . THR A 1 289 ? -4.280 -1.725 9.943 1.00 47.69 ? 289 THR A CA 1 ATOM 2231 C C . THR A 1 289 ? -2.870 -1.339 9.516 1.00 46.94 ? 289 THR A C 1 ATOM 2232 O O . THR A 1 289 ? -2.508 -0.167 9.509 1.00 47.14 ? 289 THR A O 1 ATOM 2233 C CB . THR A 1 289 ? -4.768 -1.017 11.258 1.00 47.94 ? 289 THR A CB 1 ATOM 2234 O OG1 . THR A 1 289 ? -5.740 -0.022 10.928 1.00 48.20 ? 289 THR A OG1 1 ATOM 2235 C CG2 . THR A 1 289 ? -3.613 -0.427 12.105 1.00 48.20 ? 289 THR A CG2 1 ATOM 2236 N N . THR A 1 290 ? -2.093 -2.355 9.150 1.00 46.15 ? 290 THR A N 1 ATOM 2237 C CA . THR A 1 290 ? -0.710 -2.182 8.733 1.00 45.86 ? 290 THR A CA 1 ATOM 2238 C C . THR A 1 290 ? -0.589 -1.547 7.351 1.00 46.06 ? 290 THR A C 1 ATOM 2239 O O . THR A 1 290 ? -1.582 -1.327 6.664 1.00 45.09 ? 290 THR A O 1 ATOM 2240 C CB . THR A 1 290 ? 0.079 -3.514 8.757 1.00 45.88 ? 290 THR A CB 1 ATOM 2241 O OG1 . THR A 1 290 ? -0.610 -4.504 7.971 1.00 45.81 ? 290 THR A OG1 1 ATOM 2242 C CG2 . THR A 1 290 ? 0.299 -4.016 10.211 1.00 44.76 ? 290 THR A CG2 1 ATOM 2243 N N . SER A 1 291 ? 0.654 -1.243 6.979 1.00 47.14 ? 291 SER A N 1 ATOM 2244 C CA . SER A 1 291 ? 0.990 -0.555 5.738 1.00 48.49 ? 291 SER A CA 1 ATOM 2245 C C . SER A 1 291 ? 2.009 -1.381 4.993 1.00 49.40 ? 291 SER A C 1 ATOM 2246 O O . SER A 1 291 ? 2.843 -2.041 5.616 1.00 49.68 ? 291 SER A O 1 ATOM 2247 C CB . SER A 1 291 ? 1.609 0.818 6.038 1.00 48.22 ? 291 SER A CB 1 ATOM 2248 O OG . SER A 1 291 ? 0.620 1.825 6.125 1.00 48.57 ? 291 SER A OG 1 ATOM 2249 N N . GLN A 1 292 ? 1.937 -1.379 3.635 1.00 15.00 ? 292 GLN A N 1 ATOM 2250 C CA . GLN A 1 292 ? 3.114 -1.923 2.971 1.00 15.00 ? 292 GLN A CA 1 ATOM 2251 C C . GLN A 1 292 ? 4.188 -0.853 2.798 1.00 15.00 ? 292 GLN A C 1 ATOM 2252 O O . GLN A 1 292 ? 3.888 0.354 2.801 1.00 54.25 ? 292 GLN A O 1 ATOM 2253 C CB . GLN A 1 292 ? 2.698 -2.818 1.802 1.00 15.00 ? 292 GLN A CB 1 ATOM 2254 C CG . GLN A 1 292 ? 3.442 -2.535 0.507 1.00 15.00 ? 292 GLN A CG 1 ATOM 2255 C CD . GLN A 1 292 ? 2.553 -2.653 -0.716 1.00 15.00 ? 292 GLN A CD 1 ATOM 2256 O OE1 . GLN A 1 292 ? 1.528 -1.977 -0.818 1.00 15.00 ? 292 GLN A OE1 1 ATOM 2257 N NE2 . GLN A 1 292 ? 2.941 -3.511 -1.649 1.00 15.00 ? 292 GLN A NE2 1 ATOM 2258 H H . GLN A 1 292 ? 1.932 -0.438 3.907 1.00 15.00 ? 292 GLN A H 1 ATOM 2259 H HE21 . GLN A 1 292 ? 2.408 -3.577 -2.469 1.00 15.00 ? 292 GLN A HE21 1 ATOM 2260 H HE22 . GLN A 1 292 ? 3.745 -4.047 -1.481 1.00 15.00 ? 292 GLN A HE22 1 ATOM 2261 N N . THR A 1 293 ? 5.418 -1.283 2.885 1.00 54.71 ? 293 THR A N 1 ATOM 2262 C CA . THR A 1 293 ? 6.548 -0.441 2.565 1.00 55.43 ? 293 THR A CA 1 ATOM 2263 C C . THR A 1 293 ? 6.994 -0.856 1.152 1.00 56.00 ? 293 THR A C 1 ATOM 2264 O O . THR A 1 293 ? 6.906 -2.033 0.802 1.00 55.54 ? 293 THR A O 1 ATOM 2265 C CB . THR A 1 293 ? 7.650 -0.676 3.575 1.00 55.39 ? 293 THR A CB 1 ATOM 2266 O OG1 . THR A 1 293 ? 8.181 -1.991 3.389 1.00 56.58 ? 293 THR A OG1 1 ATOM 2267 C CG2 . THR A 1 293 ? 7.086 -0.583 4.987 1.00 55.31 ? 293 THR A CG2 1 ATOM 2268 N N . PRO A 1 294 ? 7.495 0.098 0.332 1.00 57.07 ? 294 PRO A N 1 ATOM 2269 C CA . PRO A 1 294 ? 7.781 -0.289 -1.072 1.00 57.02 ? 294 PRO A CA 1 ATOM 2270 C C . PRO A 1 294 ? 8.598 -1.574 -1.068 1.00 56.56 ? 294 PRO A C 1 ATOM 2271 O O . PRO A 1 294 ? 8.463 -2.452 -1.937 1.00 56.36 ? 294 PRO A O 1 ATOM 2272 C CB . PRO A 1 294 ? 8.648 0.882 -1.592 1.00 57.04 ? 294 PRO A CB 1 ATOM 2273 C CG . PRO A 1 294 ? 9.053 1.689 -0.341 1.00 57.16 ? 294 PRO A CG 1 ATOM 2274 C CD . PRO A 1 294 ? 7.905 1.495 0.607 1.00 57.14 ? 294 PRO A CD 1 ATOM 2275 N N . SER A 1 295 ? 9.350 -1.685 0.015 1.00 55.89 ? 295 SER A N 1 ATOM 2276 C CA . SER A 1 295 ? 10.581 -2.506 0.250 1.00 55.87 ? 295 SER A CA 1 ATOM 2277 C C . SER A 1 295 ? 11.243 -3.113 -1.120 1.00 55.06 ? 295 SER A C 1 ATOM 2278 O O . SER A 1 295 ? 10.686 -3.318 -2.213 1.00 54.30 ? 295 SER A O 1 ATOM 2279 C CB . SER A 1 295 ? 10.523 -3.429 1.487 1.00 56.75 ? 295 SER A CB 1 ATOM 2280 O OG . SER A 1 295 ? 11.189 -2.841 2.620 1.00 58.27 ? 295 SER A OG 1 ATOM 2281 N N . THR A 1 296 ? 12.522 -3.358 -0.875 1.00 54.09 ? 296 THR A N 1 ATOM 2282 C CA . THR A 1 296 ? 13.504 -3.831 -1.809 1.00 52.78 ? 296 THR A CA 1 ATOM 2283 C C . THR A 1 296 ? 13.456 -5.352 -1.786 1.00 51.85 ? 296 THR A C 1 ATOM 2284 O O . THR A 1 296 ? 12.381 -5.957 -1.739 1.00 52.67 ? 296 THR A O 1 ATOM 2285 C CB . THR A 1 296 ? 14.810 -3.412 -1.224 1.00 53.20 ? 296 THR A CB 1 ATOM 2286 O OG1 . THR A 1 296 ? 14.503 -2.659 -0.033 1.00 49.76 ? 296 THR A OG1 1 ATOM 2287 C CG2 . THR A 1 296 ? 15.665 -2.590 -2.273 1.00 54.92 ? 296 THR A CG2 1 ATOM 2288 N N . ASN A 1 297 ? 14.614 -5.980 -1.809 1.00 49.41 ? 297 ASN A N 1 ATOM 2289 C CA . ASN A 1 297 ? 14.679 -7.434 -1.773 1.00 47.09 ? 297 ASN A CA 1 ATOM 2290 C C . ASN A 1 297 ? 13.554 -8.318 -2.427 1.00 44.82 ? 297 ASN A C 1 ATOM 2291 O O . ASN A 1 297 ? 13.147 -9.340 -1.832 1.00 44.66 ? 297 ASN A O 1 ATOM 2292 C CB . ASN A 1 297 ? 14.933 -7.861 -0.334 1.00 47.30 ? 297 ASN A CB 1 ATOM 2293 C CG . ASN A 1 297 ? 15.975 -8.957 -0.240 1.00 48.72 ? 297 ASN A CG 1 ATOM 2294 O OD1 . ASN A 1 297 ? 15.960 -9.780 0.693 1.00 48.94 ? 297 ASN A OD1 1 ATOM 2295 N ND2 . ASN A 1 297 ? 16.893 -8.983 -1.220 1.00 48.66 ? 297 ASN A ND2 1 ATOM 2296 N N . PRO A 1 298 ? 13.071 -7.971 -3.650 1.00 42.49 ? 298 PRO A N 1 ATOM 2297 C CA . PRO A 1 298 ? 12.152 -8.937 -4.223 1.00 40.93 ? 298 PRO A CA 1 ATOM 2298 C C . PRO A 1 298 ? 12.893 -10.162 -4.683 1.00 39.75 ? 298 PRO A C 1 ATOM 2299 O O . PRO A 1 298 ? 14.084 -10.065 -5.027 1.00 39.64 ? 298 PRO A O 1 ATOM 2300 C CB . PRO A 1 298 ? 11.630 -8.223 -5.470 1.00 41.20 ? 298 PRO A CB 1 ATOM 2301 C CG . PRO A 1 298 ? 12.757 -7.393 -5.904 1.00 41.71 ? 298 PRO A CG 1 ATOM 2302 C CD . PRO A 1 298 ? 13.245 -6.825 -4.566 1.00 42.76 ? 298 PRO A CD 1 ATOM 2303 N N . LEU A 1 299 ? 12.188 -11.298 -4.712 1.00 37.81 ? 299 LEU A N 1 ATOM 2304 C CA . LEU A 1 299 ? 12.665 -12.479 -5.410 1.00 36.45 ? 299 LEU A CA 1 ATOM 2305 C C . LEU A 1 299 ? 13.092 -12.060 -6.813 1.00 35.71 ? 299 LEU A C 1 ATOM 2306 O O . LEU A 1 299 ? 12.338 -11.393 -7.527 1.00 35.00 ? 299 LEU A O 1 ATOM 2307 C CB . LEU A 1 299 ? 11.542 -13.503 -5.461 1.00 36.67 ? 299 LEU A CB 1 ATOM 2308 C CG . LEU A 1 299 ? 11.834 -14.832 -6.201 1.00 36.67 ? 299 LEU A CG 1 ATOM 2309 C CD1 . LEU A 1 299 ? 12.046 -14.731 -7.748 1.00 28.91 ? 299 LEU A CD1 1 ATOM 2310 C CD2 . LEU A 1 299 ? 12.917 -15.632 -5.506 1.00 36.59 ? 299 LEU A CD2 1 ATOM 2311 N N . VAL A 1 300 ? 14.330 -12.401 -7.178 1.00 35.27 ? 300 VAL A N 1 ATOM 2312 C CA . VAL A 1 300 ? 14.794 -12.297 -8.571 1.00 34.14 ? 300 VAL A CA 1 ATOM 2313 C C . VAL A 1 300 ? 15.185 -13.708 -9.044 1.00 33.69 ? 300 VAL A C 1 ATOM 2314 O O . VAL A 1 300 ? 16.161 -14.314 -8.554 1.00 33.88 ? 300 VAL A O 1 ATOM 2315 C CB . VAL A 1 300 ? 15.980 -11.268 -8.746 1.00 34.05 ? 300 VAL A CB 1 ATOM 2316 C CG1 . VAL A 1 300 ? 16.241 -10.932 -10.215 1.00 32.68 ? 300 VAL A CG1 1 ATOM 2317 C CG2 . VAL A 1 300 ? 15.676 -10.003 -8.022 1.00 34.23 ? 300 VAL A CG2 1 ATOM 2318 N N . GLU A 1 301 ? 14.425 -14.228 -10.000 1.00 32.56 ? 301 GLU A N 1 ATOM 2319 C CA . GLU A 1 301 ? 14.659 -15.579 -10.481 1.00 32.16 ? 301 GLU A CA 1 ATOM 2320 C C . GLU A 1 301 ? 16.138 -15.925 -10.816 1.00 31.99 ? 301 GLU A C 1 ATOM 2321 O O . GLU A 1 301 ? 16.596 -17.039 -10.514 1.00 31.60 ? 301 GLU A O 1 ATOM 2322 C CB . GLU A 1 301 ? 13.773 -15.860 -11.688 1.00 32.30 ? 301 GLU A CB 1 ATOM 2323 C CG . GLU A 1 301 ? 13.643 -17.344 -12.062 1.00 30.75 ? 301 GLU A CG 1 ATOM 2324 C CD . GLU A 1 301 ? 12.604 -17.565 -13.123 1.00 30.80 ? 301 GLU A CD 1 ATOM 2325 O OE1 . GLU A 1 301 ? 12.707 -16.993 -14.225 1.00 32.79 ? 301 GLU A OE1 1 ATOM 2326 O OE2 . GLU A 1 301 ? 11.650 -18.295 -12.852 1.00 30.39 ? 301 GLU A OE2 1 ATOM 2327 N N . SER A 1 302 ? 16.859 -14.998 -11.454 1.00 31.45 ? 302 SER A N 1 ATOM 2328 C CA . SER A 1 302 ? 18.247 -15.280 -11.900 1.00 31.34 ? 302 SER A CA 1 ATOM 2329 C C . SER A 1 302 ? 19.179 -15.429 -10.714 1.00 30.06 ? 302 SER A C 1 ATOM 2330 O O . SER A 1 302 ? 20.216 -16.032 -10.825 1.00 29.78 ? 302 SER A O 1 ATOM 2331 C CB . SER A 1 302 ? 18.775 -14.281 -12.973 1.00 31.80 ? 302 SER A CB 1 ATOM 2332 O OG . SER A 1 302 ? 18.590 -12.902 -12.616 1.00 35.15 ? 302 SER A OG 1 ATOM 2333 N N . ALA A 1 303 ? 18.737 -14.976 -9.548 1.00 29.41 ? 303 ALA A N 1 ATOM 2334 C CA . ALA A 1 303 ? 19.511 -15.154 -8.339 1.00 28.52 ? 303 ALA A CA 1 ATOM 2335 C C . ALA A 1 303 ? 19.238 -16.447 -7.539 1.00 27.98 ? 303 ALA A C 1 ATOM 2336 O O . ALA A 1 303 ? 19.950 -16.745 -6.589 1.00 28.46 ? 303 ALA A O 1 ATOM 2337 C CB . ALA A 1 303 ? 19.411 -13.899 -7.440 1.00 28.02 ? 303 ALA A CB 1 ATOM 2338 N N . LEU A 1 304 ? 18.249 -17.244 -7.911 1.00 27.34 ? 304 LEU A N 1 ATOM 2339 C CA . LEU A 1 304 ? 18.032 -18.489 -7.171 1.00 26.63 ? 304 LEU A CA 1 ATOM 2340 C C . LEU A 1 304 ? 18.903 -19.596 -7.742 1.00 27.26 ? 304 LEU A C 1 ATOM 2341 O O . LEU A 1 304 ? 19.194 -19.566 -8.943 1.00 28.24 ? 304 LEU A O 1 ATOM 2342 C CB . LEU A 1 304 ? 16.564 -18.895 -7.220 1.00 25.96 ? 304 LEU A CB 1 ATOM 2343 C CG . LEU A 1 304 ? 15.512 -17.803 -6.977 1.00 25.91 ? 304 LEU A CG 1 ATOM 2344 C CD1 . LEU A 1 304 ? 14.184 -18.242 -7.579 1.00 26.32 ? 304 LEU A CD1 1 ATOM 2345 C CD2 . LEU A 1 304 ? 15.371 -17.379 -5.500 1.00 22.36 ? 304 LEU A CD2 1 ATOM 2346 N N . THR A 1 305 ? 19.317 -20.547 -6.896 1.00 27.11 ? 305 THR A N 1 ATOM 2347 C CA . THR A 1 305 ? 19.962 -21.792 -7.312 1.00 27.46 ? 305 THR A CA 1 ATOM 2348 C C . THR A 1 305 ? 19.311 -22.998 -6.644 1.00 28.69 ? 305 THR A C 1 ATOM 2349 O O . THR A 1 305 ? 18.727 -22.871 -5.556 1.00 29.46 ? 305 THR A O 1 ATOM 2350 C CB . THR A 1 305 ? 21.478 -21.897 -6.898 1.00 27.21 ? 305 THR A CB 1 ATOM 2351 O OG1 . THR A 1 305 ? 21.699 -21.288 -5.616 1.00 26.18 ? 305 THR A OG1 1 ATOM 2352 C CG2 . THR A 1 305 ? 22.354 -21.284 -7.864 1.00 26.78 ? 305 THR A CG2 1 ATOM 2353 N N . THR A 1 306 ? 19.476 -24.180 -7.247 1.00 29.41 ? 306 THR A N 1 ATOM 2354 C CA . THR A 1 306 ? 19.080 -25.435 -6.614 1.00 30.11 ? 306 THR A CA 1 ATOM 2355 C C . THR A 1 306 ? 19.937 -25.664 -5.384 1.00 31.02 ? 306 THR A C 1 ATOM 2356 O O . THR A 1 306 ? 21.150 -25.362 -5.375 1.00 30.94 ? 306 THR A O 1 ATOM 2357 C CB . THR A 1 306 ? 19.328 -26.639 -7.520 1.00 30.45 ? 306 THR A CB 1 ATOM 2358 O OG1 . THR A 1 306 ? 20.650 -26.539 -8.084 1.00 31.29 ? 306 THR A OG1 1 ATOM 2359 C CG2 . THR A 1 306 ? 18.290 -26.725 -8.627 1.00 29.29 ? 306 THR A CG2 1 ATOM 2360 N N . LEU A 1 307 ? 19.307 -26.214 -4.346 1.00 31.93 ? 307 LEU A N 1 ATOM 2361 C CA . LEU A 1 307 ? 19.997 -26.558 -3.112 1.00 32.37 ? 307 LEU A CA 1 ATOM 2362 C C . LEU A 1 307 ? 21.255 -27.366 -3.442 1.00 33.19 ? 307 LEU A C 1 ATOM 2363 O O . LEU A 1 307 ? 22.287 -27.166 -2.834 1.00 33.50 ? 307 LEU A O 1 ATOM 2364 C CB . LEU A 1 307 ? 19.066 -27.329 -2.194 1.00 31.82 ? 307 LEU A CB 1 ATOM 2365 C CG . LEU A 1 307 ? 19.747 -28.065 -1.057 1.00 32.26 ? 307 LEU A CG 1 ATOM 2366 C CD1 . LEU A 1 307 ? 19.900 -27.120 0.074 1.00 34.51 ? 307 LEU A CD1 1 ATOM 2367 C CD2 . LEU A 1 307 ? 18.972 -29.295 -0.631 1.00 31.60 ? 307 LEU A CD2 1 ATOM 2368 N N . GLU A 1 308 ? 21.168 -28.248 -4.434 1.00 33.93 ? 308 GLU A N 1 ATOM 2369 C CA . GLU A 1 308 ? 22.302 -29.084 -4.815 1.00 35.19 ? 308 GLU A CA 1 ATOM 2370 C C . GLU A 1 308 ? 23.282 -28.460 -5.798 1.00 34.27 ? 308 GLU A C 1 ATOM 2371 O O . GLU A 1 308 ? 24.271 -29.088 -6.135 1.00 33.52 ? 308 GLU A O 1 ATOM 2372 C CB . GLU A 1 308 ? 21.815 -30.427 -5.344 1.00 34.65 ? 308 GLU A CB 1 ATOM 2373 C CG . GLU A 1 308 ? 21.321 -31.358 -4.224 1.00 37.72 ? 308 GLU A CG 1 ATOM 2374 C CD . GLU A 1 308 ? 20.835 -32.731 -4.726 1.00 38.91 ? 308 GLU A CD 1 ATOM 2375 O OE1 . GLU A 1 308 ? 21.061 -33.083 -5.940 1.00 43.32 ? 308 GLU A OE1 1 ATOM 2376 O OE2 . GLU A 1 308 ? 20.223 -33.452 -3.888 1.00 40.63 ? 308 GLU A OE2 1 ATOM 2377 N N . GLY A 1 309 ? 23.003 -27.232 -6.247 1.00 34.61 ? 309 GLY A N 1 ATOM 2378 C CA . GLY A 1 309 ? 23.808 -26.541 -7.275 1.00 34.16 ? 309 GLY A CA 1 ATOM 2379 C C . GLY A 1 309 ? 24.041 -27.299 -8.583 1.00 33.58 ? 309 GLY A C 1 ATOM 2380 O O . GLY A 1 309 ? 25.071 -27.131 -9.223 1.00 33.74 ? 309 GLY A O 1 ATOM 2381 N N . THR A 1 310 ? 23.080 -28.136 -8.965 1.00 33.44 ? 310 THR A N 1 ATOM 2382 C CA . THR A 1 310 ? 23.105 -28.874 -10.237 1.00 33.34 ? 310 THR A CA 1 ATOM 2383 C C . THR A 1 310 ? 23.345 -27.970 -11.446 1.00 32.58 ? 310 THR A C 1 ATOM 2384 O O . THR A 1 310 ? 22.709 -26.956 -11.592 1.00 32.64 ? 310 THR A O 1 ATOM 2385 C CB . THR A 1 310 ? 21.760 -29.592 -10.438 1.00 33.77 ? 310 THR A CB 1 ATOM 2386 O OG1 . THR A 1 310 ? 21.289 -30.032 -9.169 1.00 32.98 ? 310 THR A OG1 1 ATOM 2387 C CG2 . THR A 1 310 ? 21.857 -30.791 -11.428 1.00 33.85 ? 310 THR A CG2 1 ATOM 2388 N N . ALA A 1 311 ? 24.248 -28.375 -12.318 1.00 32.55 ? 311 ALA A N 1 ATOM 2389 C CA . ALA A 1 311 ? 24.519 -27.673 -13.586 1.00 32.24 ? 311 ALA A CA 1 ATOM 2390 C C . ALA A 1 311 ? 23.410 -27.823 -14.610 1.00 31.62 ? 311 ALA A C 1 ATOM 2391 O O . ALA A 1 311 ? 22.654 -28.770 -14.581 1.00 31.42 ? 311 ALA A O 1 ATOM 2392 C CB . ALA A 1 311 ? 25.826 -28.200 -14.190 1.00 31.47 ? 311 ALA A CB 1 ATOM 2393 N N . ALA A 1 312 ? 23.337 -26.896 -15.548 1.00 32.44 ? 312 ALA A N 1 ATOM 2394 C CA . ALA A 1 312 ? 22.542 -27.140 -16.747 1.00 33.23 ? 312 ALA A CA 1 ATOM 2395 C C . ALA A 1 312 ? 23.043 -28.420 -17.454 1.00 33.48 ? 312 ALA A C 1 ATOM 2396 O O . ALA A 1 312 ? 24.235 -28.695 -17.476 1.00 33.93 ? 312 ALA A O 1 ATOM 2397 C CB . ALA A 1 312 ? 22.591 -25.935 -17.686 1.00 32.55 ? 312 ALA A CB 1 ATOM 2398 N N . PRO A 1 313 ? 22.134 -29.232 -17.997 1.00 33.82 ? 313 PRO A N 1 ATOM 2399 C CA . PRO A 1 313 ? 22.591 -30.215 -18.954 1.00 34.22 ? 313 PRO A CA 1 ATOM 2400 C C . PRO A 1 313 ? 23.283 -29.554 -20.146 1.00 34.88 ? 313 PRO A C 1 ATOM 2401 O O . PRO A 1 313 ? 22.984 -28.420 -20.494 1.00 34.55 ? 313 PRO A O 1 ATOM 2402 C CB . PRO A 1 313 ? 21.289 -30.866 -19.430 1.00 34.91 ? 313 PRO A CB 1 ATOM 2403 C CG . PRO A 1 313 ? 20.198 -29.907 -19.015 1.00 34.46 ? 313 PRO A CG 1 ATOM 2404 C CD . PRO A 1 313 ? 20.688 -29.325 -17.750 1.00 33.50 ? 313 PRO A CD 1 ATOM 2405 N N . GLY A 1 314 ? 24.207 -30.272 -20.768 1.00 35.93 ? 314 GLY A N 1 ATOM 2406 C CA . GLY A 1 314 ? 24.902 -29.770 -21.954 1.00 36.51 ? 314 GLY A CA 1 ATOM 2407 C C . GLY A 1 314 ? 26.229 -29.171 -21.574 1.00 36.95 ? 314 GLY A C 1 ATOM 2408 O O . GLY A 1 314 ? 26.683 -29.352 -20.458 1.00 37.55 ? 314 GLY A O 1 ATOM 2409 N N . SER A 1 315 ? 26.842 -28.453 -22.499 1.00 37.10 ? 315 SER A N 1 ATOM 2410 C CA . SER A 1 315 ? 28.046 -27.704 -22.212 1.00 38.52 ? 315 SER A CA 1 ATOM 2411 C C . SER A 1 315 ? 27.763 -26.183 -22.064 1.00 38.70 ? 315 SER A C 1 ATOM 2412 O O . SER A 1 315 ? 26.797 -25.675 -22.647 1.00 38.81 ? 315 SER A O 1 ATOM 2413 C CB . SER A 1 315 ? 29.108 -28.003 -23.280 1.00 39.20 ? 315 SER A CB 1 ATOM 2414 O OG . SER A 1 315 ? 28.514 -28.305 -24.540 1.00 41.18 ? 315 SER A OG 1 ATOM 2415 N N . PRO A 1 316 ? 28.585 -25.459 -21.259 1.00 38.91 ? 316 PRO A N 1 ATOM 2416 C CA . PRO A 1 316 ? 28.336 -24.025 -20.950 1.00 38.56 ? 316 PRO A CA 1 ATOM 2417 C C . PRO A 1 316 ? 28.443 -23.009 -22.102 1.00 38.27 ? 316 PRO A C 1 ATOM 2418 O O . PRO A 1 316 ? 29.213 -22.050 -22.015 1.00 38.56 ? 316 PRO A O 1 ATOM 2419 C CB . PRO A 1 316 ? 29.369 -23.707 -19.857 1.00 38.42 ? 316 PRO A CB 1 ATOM 2420 C CG . PRO A 1 316 ? 30.462 -24.709 -20.064 1.00 39.24 ? 316 PRO A CG 1 ATOM 2421 C CD . PRO A 1 316 ? 29.774 -25.971 -20.534 1.00 39.38 ? 316 PRO A CD 1 ATOM 2422 N N . ALA A 1 317 ? 27.652 -23.181 -23.152 1.00 37.78 ? 317 ALA A N 1 ATOM 2423 C CA . ALA A 1 317 ? 27.691 -22.245 -24.275 1.00 37.40 ? 317 ALA A CA 1 ATOM 2424 C C . ALA A 1 317 ? 26.394 -22.366 -25.021 1.00 37.08 ? 317 ALA A C 1 ATOM 2425 O O . ALA A 1 317 ? 25.857 -23.452 -25.132 1.00 37.45 ? 317 ALA A O 1 ATOM 2426 C CB . ALA A 1 317 ? 28.884 -22.533 -25.213 1.00 37.05 ? 317 ALA A CB 1 ATOM 2427 N N . PRO A 1 318 ? 25.877 -21.241 -25.535 1.00 37.27 ? 318 PRO A N 1 ATOM 2428 C CA . PRO A 1 318 ? 24.660 -21.239 -26.386 1.00 36.51 ? 318 PRO A CA 1 ATOM 2429 C C . PRO A 1 318 ? 24.687 -22.322 -27.458 1.00 36.12 ? 318 PRO A C 1 ATOM 2430 O O . PRO A 1 318 ? 25.637 -22.394 -28.261 1.00 36.01 ? 318 PRO A O 1 ATOM 2431 C CB . PRO A 1 318 ? 24.685 -19.844 -27.011 1.00 36.43 ? 318 PRO A CB 1 ATOM 2432 C CG . PRO A 1 318 ? 25.309 -18.978 -25.891 1.00 37.37 ? 318 PRO A CG 1 ATOM 2433 C CD . PRO A 1 318 ? 26.413 -19.874 -25.318 1.00 37.04 ? 318 PRO A CD 1 ATOM 2434 N N . GLY A 1 319 ? 23.658 -23.169 -27.462 1.00 35.62 ? 319 GLY A N 1 ATOM 2435 C CA . GLY A 1 319 ? 23.579 -24.288 -28.427 1.00 34.55 ? 319 GLY A CA 1 ATOM 2436 C C . GLY A 1 319 ? 24.371 -25.547 -28.068 1.00 33.88 ? 319 GLY A C 1 ATOM 2437 O O . GLY A 1 319 ? 24.384 -26.510 -28.846 1.00 33.80 ? 319 GLY A O 1 ATOM 2438 N N . GLY A 1 320 ? 25.025 -25.536 -26.900 1.00 32.58 ? 320 GLY A N 1 ATOM 2439 C CA . GLY A 1 320 ? 25.833 -26.658 -26.417 1.00 32.17 ? 320 GLY A CA 1 ATOM 2440 C C . GLY A 1 320 ? 25.083 -27.903 -25.965 1.00 31.59 ? 320 GLY A C 1 ATOM 2441 O O . GLY A 1 320 ? 25.257 -28.393 -24.859 1.00 30.76 ? 320 GLY A O 1 ATOM 2442 N N . VAL A 1 321 ? 24.264 -28.434 -26.849 1.00 31.76 ? 321 VAL A N 1 ATOM 2443 C CA . VAL A 1 321 ? 23.341 -29.509 -26.497 1.00 31.91 ? 321 VAL A CA 1 ATOM 2444 C C . VAL A 1 321 ? 23.190 -30.392 -27.721 1.00 31.93 ? 321 VAL A C 1 ATOM 2445 O O . VAL A 1 321 ? 23.794 -30.128 -28.753 1.00 32.05 ? 321 VAL A O 1 ATOM 2446 C CB . VAL A 1 321 ? 21.930 -28.934 -26.138 1.00 32.20 ? 321 VAL A CB 1 ATOM 2447 C CG1 . VAL A 1 321 ? 21.879 -28.367 -24.698 1.00 30.68 ? 321 VAL A CG1 1 ATOM 2448 C CG2 . VAL A 1 321 ? 21.504 -27.894 -27.178 1.00 31.23 ? 321 VAL A CG2 1 ATOM 2449 N N . ASP A 1 322 ? 22.358 -31.411 -27.632 1.00 31.90 ? 322 ASP A N 1 ATOM 2450 C CA . ASP A 1 322 ? 22.152 -32.283 -28.773 1.00 32.00 ? 322 ASP A CA 1 ATOM 2451 C C . ASP A 1 322 ? 21.145 -31.678 -29.772 1.00 31.91 ? 322 ASP A C 1 ATOM 2452 O O . ASP A 1 322 ? 21.319 -31.808 -31.003 1.00 31.51 ? 322 ASP A O 1 ATOM 2453 C CB . ASP A 1 322 ? 21.778 -33.673 -28.279 1.00 31.60 ? 322 ASP A CB 1 ATOM 2454 C CG . ASP A 1 322 ? 22.911 -34.314 -27.532 1.00 33.91 ? 322 ASP A CG 1 ATOM 2455 O OD1 . ASP A 1 322 ? 23.978 -34.554 -28.173 1.00 36.46 ? 322 ASP A OD1 1 ATOM 2456 O OD2 . ASP A 1 322 ? 22.777 -34.540 -26.304 1.00 35.36 ? 322 ASP A OD2 1 ATOM 2457 N N . LEU A 1 323 ? 20.119 -31.005 -29.231 1.00 31.46 ? 323 LEU A N 1 ATOM 2458 C CA . LEU A 1 323 ? 19.092 -30.333 -30.035 1.00 30.68 ? 323 LEU A CA 1 ATOM 2459 C C . LEU A 1 323 ? 18.682 -29.013 -29.401 1.00 30.29 ? 323 LEU A C 1 ATOM 2460 O O . LEU A 1 323 ? 18.359 -28.921 -28.211 1.00 30.86 ? 323 LEU A O 1 ATOM 2461 C CB . LEU A 1 323 ? 17.891 -31.247 -30.248 1.00 30.66 ? 323 LEU A CB 1 ATOM 2462 C CG . LEU A 1 323 ? 16.679 -30.807 -31.071 1.00 31.50 ? 323 LEU A CG 1 ATOM 2463 C CD1 . LEU A 1 323 ? 17.027 -30.503 -32.550 1.00 30.91 ? 323 LEU A CD1 1 ATOM 2464 C CD2 . LEU A 1 323 ? 15.651 -31.915 -30.996 1.00 30.75 ? 323 LEU A CD2 1 ATOM 2465 N N . ALA A 1 324 ? 18.743 -27.971 -30.206 1.00 30.27 ? 324 ALA A N 1 ATOM 2466 C CA . ALA A 1 324 ? 18.430 -26.630 -29.778 1.00 29.71 ? 324 ALA A CA 1 ATOM 2467 C C . ALA A 1 324 ? 17.199 -26.271 -30.555 1.00 30.36 ? 324 ALA A C 1 ATOM 2468 O O . ALA A 1 324 ? 17.127 -26.532 -31.755 1.00 30.31 ? 324 ALA A O 1 ATOM 2469 C CB . ALA A 1 324 ? 19.534 -25.746 -30.140 1.00 29.29 ? 324 ALA A CB 1 ATOM 2470 N N . LEU A 1 325 ? 16.195 -25.728 -29.874 1.00 31.42 ? 325 LEU A N 1 ATOM 2471 C CA . LEU A 1 325 ? 14.928 -25.359 -30.545 1.00 31.45 ? 325 LEU A CA 1 ATOM 2472 C C . LEU A 1 325 ? 14.566 -23.956 -30.163 1.00 31.81 ? 325 LEU A C 1 ATOM 2473 O O . LEU A 1 325 ? 14.771 -23.529 -29.011 1.00 32.55 ? 325 LEU A O 1 ATOM 2474 C CB . LEU A 1 325 ? 13.777 -26.292 -30.174 1.00 31.03 ? 325 LEU A CB 1 ATOM 2475 C CG . LEU A 1 325 ? 13.797 -27.788 -30.513 1.00 30.47 ? 325 LEU A CG 1 ATOM 2476 C CD1 . LEU A 1 325 ? 12.598 -28.520 -29.856 1.00 27.09 ? 325 LEU A CD1 1 ATOM 2477 C CD2 . LEU A 1 325 ? 13.787 -27.997 -32.027 1.00 29.55 ? 325 LEU A CD2 1 ATOM 2478 N N . ASN A 1 326 ? 14.046 -23.219 -31.130 1.00 32.24 ? 326 ASN A N 1 ATOM 2479 C CA . ASN A 1 326 ? 13.591 -21.876 -30.839 1.00 32.38 ? 326 ASN A CA 1 ATOM 2480 C C . ASN A 1 326 ? 12.109 -21.787 -31.125 1.00 32.57 ? 326 ASN A C 1 ATOM 2481 O O . ASN A 1 326 ? 11.654 -22.183 -32.198 1.00 32.81 ? 326 ASN A O 1 ATOM 2482 C CB . ASN A 1 326 ? 14.349 -20.848 -31.642 1.00 31.92 ? 326 ASN A CB 1 ATOM 2483 C CG . ASN A 1 326 ? 13.929 -19.446 -31.301 1.00 33.78 ? 326 ASN A CG 1 ATOM 2484 O OD1 . ASN A 1 326 ? 14.246 -18.936 -30.208 1.00 34.71 ? 326 ASN A OD1 1 ATOM 2485 N ND2 . ASN A 1 326 ? 13.216 -18.798 -32.226 1.00 30.71 ? 326 ASN A ND2 1 ATOM 2486 N N . MET A 1 327 ? 11.362 -21.302 -30.139 1.00 32.58 ? 327 MET A N 1 ATOM 2487 C CA . MET A 1 327 ? 9.913 -21.180 -30.232 1.00 32.22 ? 327 MET A CA 1 ATOM 2488 C C . MET A 1 327 ? 9.564 -19.717 -30.568 1.00 31.83 ? 327 MET A C 1 ATOM 2489 O O . MET A 1 327 ? 9.683 -18.829 -29.726 1.00 31.09 ? 327 MET A O 1 ATOM 2490 C CB . MET A 1 327 ? 9.245 -21.625 -28.907 1.00 32.59 ? 327 MET A CB 1 ATOM 2491 C CG . MET A 1 327 ? 9.454 -23.078 -28.500 1.00 31.64 ? 327 MET A CG 1 ATOM 2492 S SD . MET A 1 327 ? 8.988 -24.211 -29.820 1.00 32.10 ? 327 MET A SD 1 ATOM 2493 C CE . MET A 1 327 ? 9.748 -25.711 -29.202 1.00 34.22 ? 327 MET A CE 1 ATOM 2494 N N . ALA A 1 328 ? 9.152 -19.468 -31.799 1.00 31.54 ? 328 ALA A N 1 ATOM 2495 C CA . ALA A 1 328 ? 8.784 -18.106 -32.203 1.00 32.05 ? 328 ALA A CA 1 ATOM 2496 C C . ALA A 1 328 ? 7.297 -17.826 -31.950 1.00 31.89 ? 328 ALA A C 1 ATOM 2497 O O . ALA A 1 328 ? 6.431 -18.380 -32.605 1.00 31.81 ? 328 ALA A O 1 ATOM 2498 C CB . ALA A 1 328 ? 9.176 -17.838 -33.691 1.00 31.12 ? 328 ALA A CB 1 ATOM 2499 N N . PHE A 1 329 ? 7.008 -16.961 -30.991 1.00 32.66 ? 329 PHE A N 1 ATOM 2500 C CA . PHE A 1 329 ? 5.625 -16.651 -30.645 1.00 33.13 ? 329 PHE A CA 1 ATOM 2501 C C . PHE A 1 329 ? 5.018 -15.739 -31.701 1.00 35.01 ? 329 PHE A C 1 ATOM 2502 O O . PHE A 1 329 ? 5.722 -14.930 -32.329 1.00 34.24 ? 329 PHE A O 1 ATOM 2503 C CB . PHE A 1 329 ? 5.525 -15.976 -29.279 1.00 31.75 ? 329 PHE A CB 1 ATOM 2504 C CG . PHE A 1 329 ? 6.033 -16.812 -28.148 1.00 29.46 ? 329 PHE A CG 1 ATOM 2505 C CD1 . PHE A 1 329 ? 6.321 -16.236 -26.939 1.00 27.10 ? 329 PHE A CD1 1 ATOM 2506 C CD2 . PHE A 1 329 ? 6.223 -18.182 -28.295 1.00 28.26 ? 329 PHE A CD2 1 ATOM 2507 C CE1 . PHE A 1 329 ? 6.806 -16.993 -25.895 1.00 27.32 ? 329 PHE A CE1 1 ATOM 2508 C CE2 . PHE A 1 329 ? 6.700 -18.951 -27.257 1.00 25.49 ? 329 PHE A CE2 1 ATOM 2509 C CZ . PHE A 1 329 ? 6.993 -18.349 -26.052 1.00 27.93 ? 329 PHE A CZ 1 ATOM 2510 N N . GLY A 1 330 ? 3.705 -15.883 -31.879 1.00 36.86 ? 330 GLY A N 1 ATOM 2511 C CA . GLY A 1 330 ? 2.949 -15.077 -32.827 1.00 39.32 ? 330 GLY A CA 1 ATOM 2512 C C . GLY A 1 330 ? 1.462 -15.196 -32.586 1.00 40.99 ? 330 GLY A C 1 ATOM 2513 O O . GLY A 1 330 ? 1.011 -16.018 -31.781 1.00 40.63 ? 330 GLY A O 1 ATOM 2514 N N . PHE A 1 331 ? 0.695 -14.393 -33.310 1.00 42.66 ? 331 PHE A N 1 ATOM 2515 C CA . PHE A 1 331 ? -0.736 -14.412 -33.146 1.00 44.41 ? 331 PHE A CA 1 ATOM 2516 C C . PHE A 1 331 ? -1.374 -14.088 -34.467 1.00 45.39 ? 331 PHE A C 1 ATOM 2517 O O . PHE A 1 331 ? -1.379 -12.938 -34.868 1.00 45.56 ? 331 PHE A O 1 ATOM 2518 C CB . PHE A 1 331 ? -1.120 -13.383 -32.093 1.00 44.82 ? 331 PHE A CB 1 ATOM 2519 C CG . PHE A 1 331 ? -2.558 -13.441 -31.664 1.00 45.61 ? 331 PHE A CG 1 ATOM 2520 C CD1 . PHE A 1 331 ? -2.938 -14.200 -30.576 1.00 45.88 ? 331 PHE A CD1 1 ATOM 2521 C CD2 . PHE A 1 331 ? -3.529 -12.685 -32.324 1.00 47.38 ? 331 PHE A CD2 1 ATOM 2522 C CE1 . PHE A 1 331 ? -4.279 -14.226 -30.150 1.00 48.47 ? 331 PHE A CE1 1 ATOM 2523 C CE2 . PHE A 1 331 ? -4.869 -12.697 -31.908 1.00 48.80 ? 331 PHE A CE2 1 ATOM 2524 C CZ . PHE A 1 331 ? -5.243 -13.471 -30.811 1.00 47.56 ? 331 PHE A CZ 1 ATOM 2525 N N . ALA A 1 332 ? -1.895 -15.107 -35.156 1.00 47.02 ? 332 ALA A N 1 ATOM 2526 C CA . ALA A 1 332 ? -2.536 -14.892 -36.474 1.00 48.22 ? 332 ALA A CA 1 ATOM 2527 C C . ALA A 1 332 ? -4.008 -14.508 -36.310 1.00 48.61 ? 332 ALA A C 1 ATOM 2528 O O . ALA A 1 332 ? -4.269 -13.341 -36.026 1.00 50.42 ? 332 ALA A O 1 ATOM 2529 C CB . ALA A 1 332 ? -2.323 -16.069 -37.455 1.00 47.82 ? 332 ALA A CB 1 ATOM 2530 N N . GLY A 1 333 ? -4.955 -15.437 -36.451 1.00 48.40 ? 333 GLY A N 1 ATOM 2531 C CA . GLY A 1 333 ? -6.380 -15.076 -36.418 1.00 47.54 ? 333 GLY A CA 1 ATOM 2532 C C . GLY A 1 333 ? -6.710 -14.394 -35.100 1.00 47.39 ? 333 GLY A C 1 ATOM 2533 O O . GLY A 1 333 ? -6.154 -13.346 -34.792 1.00 48.49 ? 333 GLY A O 1 ATOM 2534 N N . GLY A 1 334 ? -7.621 -14.954 -34.318 1.00 46.12 ? 334 GLY A N 1 ATOM 2535 C CA . GLY A 1 334 ? -7.656 -14.646 -32.888 1.00 44.80 ? 334 GLY A CA 1 ATOM 2536 C C . GLY A 1 334 ? -6.944 -15.777 -32.131 1.00 43.87 ? 334 GLY A C 1 ATOM 2537 O O . GLY A 1 334 ? -7.331 -16.130 -31.001 1.00 43.85 ? 334 GLY A O 1 ATOM 2538 N N . LYS A 1 335 ? -5.909 -16.342 -32.764 1.00 42.39 ? 335 LYS A N 1 ATOM 2539 C CA . LYS A 1 335 ? -5.254 -17.576 -32.302 1.00 41.39 ? 335 LYS A CA 1 ATOM 2540 C C . LYS A 1 335 ? -3.723 -17.450 -32.103 1.00 39.93 ? 335 LYS A C 1 ATOM 2541 O O . LYS A 1 335 ? -3.024 -16.937 -32.978 1.00 40.21 ? 335 LYS A O 1 ATOM 2542 C CB . LYS A 1 335 ? -5.590 -18.725 -33.269 1.00 41.57 ? 335 LYS A CB 1 ATOM 2543 C CG . LYS A 1 335 ? -7.103 -18.912 -33.557 1.00 43.08 ? 335 LYS A CG 1 ATOM 2544 C CD . LYS A 1 335 ? -7.956 -19.144 -32.278 1.00 46.23 ? 335 LYS A CD 1 ATOM 2545 C CE . LYS A 1 335 ? -9.286 -19.945 -32.542 1.00 46.43 ? 335 LYS A CE 1 ATOM 2546 N NZ . LYS A 1 335 ? -10.585 -19.135 -32.491 1.00 47.36 ? 335 LYS A NZ 1 ATOM 2547 N N . PHE A 1 336 ? -3.198 -17.905 -30.961 1.00 38.30 ? 336 PHE A N 1 ATOM 2548 C CA . PHE A 1 336 ? -1.726 -17.915 -30.731 1.00 36.25 ? 336 PHE A CA 1 ATOM 2549 C C . PHE A 1 336 ? -0.981 -18.927 -31.596 1.00 35.63 ? 336 PHE A C 1 ATOM 2550 O O . PHE A 1 336 ? -1.514 -19.968 -32.015 1.00 34.74 ? 336 PHE A O 1 ATOM 2551 C CB . PHE A 1 336 ? -1.352 -18.133 -29.263 1.00 35.78 ? 336 PHE A CB 1 ATOM 2552 C CG . PHE A 1 336 ? -1.659 -16.963 -28.372 1.00 35.73 ? 336 PHE A CG 1 ATOM 2553 C CD1 . PHE A 1 336 ? -0.676 -16.047 -28.046 1.00 34.57 ? 336 PHE A CD1 1 ATOM 2554 C CD2 . PHE A 1 336 ? -2.943 -16.771 -27.859 1.00 35.53 ? 336 PHE A CD2 1 ATOM 2555 C CE1 . PHE A 1 336 ? -0.959 -14.968 -27.215 1.00 33.37 ? 336 PHE A CE1 1 ATOM 2556 C CE2 . PHE A 1 336 ? -3.228 -15.684 -27.047 1.00 34.27 ? 336 PHE A CE2 1 ATOM 2557 C CZ . PHE A 1 336 ? -2.228 -14.794 -26.715 1.00 34.40 ? 336 PHE A CZ 1 ATOM 2558 N N . THR A 1 337 ? 0.275 -18.600 -31.851 1.00 34.76 ? 337 THR A N 1 ATOM 2559 C CA . THR A 1 337 ? 1.038 -19.316 -32.831 1.00 34.12 ? 337 THR A CA 1 ATOM 2560 C C . THR A 1 337 ? 2.461 -19.520 -32.289 1.00 33.60 ? 337 THR A C 1 ATOM 2561 O O . THR A 1 337 ? 3.036 -18.614 -31.674 1.00 32.97 ? 337 THR A O 1 ATOM 2562 C CB . THR A 1 337 ? 0.922 -18.581 -34.225 1.00 34.04 ? 337 THR A CB 1 ATOM 2563 O OG1 . THR A 1 337 ? 1.094 -19.517 -35.268 1.00 37.54 ? 337 THR A OG1 1 ATOM 2564 C CG2 . THR A 1 337 ? 1.904 -17.478 -34.431 1.00 33.44 ? 337 THR A CG2 1 ATOM 2565 N N . ILE A 1 338 ? 2.971 -20.747 -32.441 1.00 33.12 ? 338 ILE A N 1 ATOM 2566 C CA . ILE A 1 338 ? 4.345 -21.098 -32.115 1.00 31.72 ? 338 ILE A CA 1 ATOM 2567 C C . ILE A 1 338 ? 4.985 -21.639 -33.395 1.00 32.34 ? 338 ILE A C 1 ATOM 2568 O O . ILE A 1 338 ? 4.599 -22.712 -33.904 1.00 32.47 ? 338 ILE A O 1 ATOM 2569 C CB . ILE A 1 338 ? 4.448 -22.142 -30.958 1.00 31.59 ? 338 ILE A CB 1 ATOM 2570 C CG1 . ILE A 1 338 ? 3.891 -21.562 -29.669 1.00 28.76 ? 338 ILE A CG1 1 ATOM 2571 C CG2 . ILE A 1 338 ? 5.909 -22.521 -30.699 1.00 29.37 ? 338 ILE A CG2 1 ATOM 2572 C CD1 . ILE A 1 338 ? 3.817 -22.537 -28.535 1.00 27.27 ? 338 ILE A CD1 1 ATOM 2573 N N . ASN A 1 339 ? 5.957 -20.891 -33.908 1.00 31.89 ? 339 ASN A N 1 ATOM 2574 C CA . ASN A 1 339 ? 6.615 -21.211 -35.177 1.00 32.15 ? 339 ASN A CA 1 ATOM 2575 C C . ASN A 1 339 ? 5.590 -21.340 -36.346 1.00 32.47 ? 339 ASN A C 1 ATOM 2576 O O . ASN A 1 339 ? 5.801 -22.075 -37.308 1.00 31.82 ? 339 ASN A O 1 ATOM 2577 C CB . ASN A 1 339 ? 7.544 -22.443 -35.054 1.00 31.06 ? 339 ASN A CB 1 ATOM 2578 C CG . ASN A 1 339 ? 8.776 -22.194 -34.145 1.00 31.62 ? 339 ASN A CG 1 ATOM 2579 O OD1 . ASN A 1 339 ? 9.206 -21.051 -33.914 1.00 29.47 ? 339 ASN A OD1 1 ATOM 2580 N ND2 . ASN A 1 339 ? 9.351 -23.288 -33.626 1.00 29.90 ? 339 ASN A ND2 1 ATOM 2581 N N . GLY A 1 340 ? 4.476 -20.627 -36.240 1.00 32.50 ? 340 GLY A N 1 ATOM 2582 C CA . GLY A 1 340 ? 3.558 -20.508 -37.367 1.00 33.42 ? 340 GLY A CA 1 ATOM 2583 C C . GLY A 1 340 ? 2.325 -21.378 -37.255 1.00 33.95 ? 340 GLY A C 1 ATOM 2584 O O . GLY A 1 340 ? 1.377 -21.210 -38.023 1.00 33.98 ? 340 GLY A O 1 ATOM 2585 N N . ALA A 1 341 ? 2.341 -22.277 -36.266 1.00 33.93 ? 341 ALA A N 1 ATOM 2586 C CA . ALA A 1 341 ? 1.315 -23.296 -36.076 1.00 33.36 ? 341 ALA A CA 1 ATOM 2587 C C . ALA A 1 341 ? 0.548 -23.094 -34.768 1.00 33.75 ? 341 ALA A C 1 ATOM 2588 O O . ALA A 1 341 ? 1.126 -22.773 -33.727 1.00 34.23 ? 341 ALA A O 1 ATOM 2589 C CB . ALA A 1 341 ? 1.937 -24.644 -36.095 1.00 32.37 ? 341 ALA A CB 1 ATOM 2590 N N . SER A 1 342 ? -0.757 -23.309 -34.828 1.00 33.59 ? 342 SER A N 1 ATOM 2591 C CA . SER A 1 342 ? -1.617 -23.024 -33.712 1.00 33.89 ? 342 SER A CA 1 ATOM 2592 C C . SER A 1 342 ? -2.194 -24.326 -33.212 1.00 34.64 ? 342 SER A C 1 ATOM 2593 O O . SER A 1 342 ? -2.695 -25.127 -34.010 1.00 35.01 ? 342 SER A O 1 ATOM 2594 C CB . SER A 1 342 ? -2.735 -22.090 -34.132 1.00 33.05 ? 342 SER A CB 1 ATOM 2595 O OG . SER A 1 342 ? -3.398 -21.668 -32.974 1.00 34.20 ? 342 SER A OG 1 ATOM 2596 N N . PHE A 1 343 ? -2.119 -24.564 -31.904 1.00 34.76 ? 343 PHE A N 1 ATOM 2597 C CA . PHE A 1 343 ? -2.569 -25.843 -31.418 1.00 35.16 ? 343 PHE A CA 1 ATOM 2598 C C . PHE A 1 343 ? -4.090 -25.914 -31.453 1.00 35.89 ? 343 PHE A C 1 ATOM 2599 O O . PHE A 1 343 ? -4.773 -25.055 -30.906 1.00 36.32 ? 343 PHE A O 1 ATOM 2600 C CB . PHE A 1 343 ? -2.032 -26.132 -30.022 1.00 35.14 ? 343 PHE A CB 1 ATOM 2601 C CG . PHE A 1 343 ? -2.214 -27.554 -29.585 1.00 34.07 ? 343 PHE A CG 1 ATOM 2602 C CD1 . PHE A 1 343 ? -1.261 -28.505 -29.874 1.00 34.23 ? 343 PHE A CD1 1 ATOM 2603 C CD2 . PHE A 1 343 ? -3.338 -27.939 -28.875 1.00 36.76 ? 343 PHE A CD2 1 ATOM 2604 C CE1 . PHE A 1 343 ? -1.403 -29.832 -29.453 1.00 34.43 ? 343 PHE A CE1 1 ATOM 2605 C CE2 . PHE A 1 343 ? -3.501 -29.270 -28.463 1.00 36.85 ? 343 PHE A CE2 1 ATOM 2606 C CZ . PHE A 1 343 ? -2.520 -30.215 -28.758 1.00 35.74 ? 343 PHE A CZ 1 ATOM 2607 N N . THR A 1 344 ? -4.600 -26.929 -32.144 1.00 36.33 ? 344 THR A N 1 ATOM 2608 C CA . THR A 1 344 ? -6.008 -27.323 -32.060 1.00 36.65 ? 344 THR A CA 1 ATOM 2609 C C . THR A 1 344 ? -5.984 -28.771 -31.557 1.00 35.30 ? 344 THR A C 1 ATOM 2610 O O . THR A 1 344 ? -5.196 -29.558 -32.048 1.00 34.88 ? 344 THR A O 1 ATOM 2611 C CB . THR A 1 344 ? -6.732 -27.236 -33.448 1.00 37.06 ? 344 THR A CB 1 ATOM 2612 O OG1 . THR A 1 344 ? -6.385 -28.393 -34.248 1.00 39.99 ? 344 THR A OG1 1 ATOM 2613 C CG2 . THR A 1 344 ? -6.364 -25.933 -34.198 1.00 36.19 ? 344 THR A CG2 1 ATOM 2614 N N . PRO A 1 345 ? -6.777 -29.101 -30.536 1.00 34.45 ? 345 PRO A N 1 ATOM 2615 C CA . PRO A 1 345 ? -6.843 -30.503 -30.046 1.00 34.32 ? 345 PRO A CA 1 ATOM 2616 C C . PRO A 1 345 ? -7.271 -31.522 -31.095 1.00 33.30 ? 345 PRO A C 1 ATOM 2617 O O . PRO A 1 345 ? -8.302 -31.347 -31.742 1.00 33.52 ? 345 PRO A O 1 ATOM 2618 C CB . PRO A 1 345 ? -7.862 -30.462 -28.891 1.00 34.08 ? 345 PRO A CB 1 ATOM 2619 C CG . PRO A 1 345 ? -8.504 -29.099 -28.977 1.00 35.27 ? 345 PRO A CG 1 ATOM 2620 C CD . PRO A 1 345 ? -7.570 -28.181 -29.715 1.00 34.83 ? 345 PRO A CD 1 ATOM 2621 N N . PRO A 1 346 ? -6.450 -32.553 -31.301 1.00 32.26 ? 346 PRO A N 1 ATOM 2622 C CA . PRO A 1 346 ? -6.745 -33.579 -32.265 1.00 31.86 ? 346 PRO A CA 1 ATOM 2623 C C . PRO A 1 346 ? -7.873 -34.474 -31.807 1.00 32.12 ? 346 PRO A C 1 ATOM 2624 O O . PRO A 1 346 ? -8.072 -34.664 -30.611 1.00 32.25 ? 346 PRO A O 1 ATOM 2625 C CB . PRO A 1 346 ? -5.446 -34.378 -32.298 1.00 31.81 ? 346 PRO A CB 1 ATOM 2626 C CG . PRO A 1 346 ? -4.834 -34.171 -30.973 1.00 30.86 ? 346 PRO A CG 1 ATOM 2627 C CD . PRO A 1 346 ? -5.134 -32.762 -30.672 1.00 32.30 ? 346 PRO A CD 1 ATOM 2628 N N . THR A 1 347 ? -8.602 -35.052 -32.751 1.00 32.40 ? 347 THR A N 1 ATOM 2629 C CA . THR A 1 347 ? -9.609 -36.048 -32.383 1.00 32.62 ? 347 THR A CA 1 ATOM 2630 C C . THR A 1 347 ? -9.021 -37.239 -31.604 1.00 31.93 ? 347 THR A C 1 ATOM 2631 O O . THR A 1 347 ? -9.592 -37.678 -30.614 1.00 31.34 ? 347 THR A O 1 ATOM 2632 C CB . THR A 1 347 ? -10.410 -36.490 -33.620 1.00 33.35 ? 347 THR A CB 1 ATOM 2633 O OG1 . THR A 1 347 ? -11.177 -35.363 -34.076 1.00 33.80 ? 347 THR A OG1 1 ATOM 2634 C CG2 . THR A 1 347 ? -11.355 -37.713 -33.302 1.00 32.03 ? 347 THR A CG2 1 ATOM 2635 N N . VAL A 1 348 ? -7.871 -37.740 -32.041 1.00 31.67 ? 348 VAL A N 1 ATOM 2636 C CA . VAL A 1 348 ? -7.263 -38.894 -31.379 1.00 31.36 ? 348 VAL A CA 1 ATOM 2637 C C . VAL A 1 348 ? -6.139 -38.358 -30.521 1.00 31.03 ? 348 VAL A C 1 ATOM 2638 O O . VAL A 1 348 ? -5.242 -37.695 -31.044 1.00 31.70 ? 348 VAL A O 1 ATOM 2639 C CB . VAL A 1 348 ? -6.712 -39.957 -32.415 1.00 32.04 ? 348 VAL A CB 1 ATOM 2640 C CG1 . VAL A 1 348 ? -6.120 -41.164 -31.704 1.00 31.24 ? 348 VAL A CG1 1 ATOM 2641 C CG2 . VAL A 1 348 ? -7.787 -40.400 -33.425 1.00 29.51 ? 348 VAL A CG2 1 ATOM 2642 N N . PRO A 1 349 ? -6.169 -38.619 -29.199 1.00 30.60 ? 349 PRO A N 1 ATOM 2643 C CA . PRO A 1 349 ? -5.096 -38.034 -28.375 1.00 30.34 ? 349 PRO A CA 1 ATOM 2644 C C . PRO A 1 349 ? -3.681 -38.363 -28.887 1.00 30.18 ? 349 PRO A C 1 ATOM 2645 O O . PRO A 1 349 ? -3.437 -39.494 -29.363 1.00 30.46 ? 349 PRO A O 1 ATOM 2646 C CB . PRO A 1 349 ? -5.325 -38.656 -26.991 1.00 29.47 ? 349 PRO A CB 1 ATOM 2647 C CG . PRO A 1 349 ? -6.730 -39.031 -26.979 1.00 30.32 ? 349 PRO A CG 1 ATOM 2648 C CD . PRO A 1 349 ? -7.107 -39.411 -28.381 1.00 30.72 ? 349 PRO A CD 1 ATOM 2649 N N . VAL A 1 350 ? -2.759 -37.410 -28.758 1.00 29.61 ? 350 VAL A N 1 ATOM 2650 C CA . VAL A 1 350 ? -1.401 -37.604 -29.269 1.00 29.43 ? 350 VAL A CA 1 ATOM 2651 C C . VAL A 1 350 ? -0.760 -38.920 -28.803 1.00 30.04 ? 350 VAL A C 1 ATOM 2652 O O . VAL A 1 350 ? -0.089 -39.592 -29.597 1.00 31.02 ? 350 VAL A O 1 ATOM 2653 C CB . VAL A 1 350 ? -0.460 -36.412 -29.014 1.00 28.81 ? 350 VAL A CB 1 ATOM 2654 C CG1 . VAL A 1 350 ? 0.837 -36.633 -29.745 1.00 26.59 ? 350 VAL A CG1 1 ATOM 2655 C CG2 . VAL A 1 350 ? -1.100 -35.094 -29.488 1.00 28.26 ? 350 VAL A CG2 1 ATOM 2656 N N . LEU A 1 351 ? -0.986 -39.301 -27.552 1.00 29.79 ? 351 LEU A N 1 ATOM 2657 C CA . LEU A 1 351 ? -0.451 -40.566 -27.044 1.00 30.20 ? 351 LEU A CA 1 ATOM 2658 C C . LEU A 1 351 ? -1.061 -41.784 -27.735 1.00 30.76 ? 351 LEU A C 1 ATOM 2659 O O . LEU A 1 351 ? -0.346 -42.706 -28.101 1.00 31.14 ? 351 LEU A O 1 ATOM 2660 C CB . LEU A 1 351 ? -0.620 -40.679 -25.529 1.00 29.70 ? 351 LEU A CB 1 ATOM 2661 C CG . LEU A 1 351 ? -0.195 -42.008 -24.911 1.00 28.55 ? 351 LEU A CG 1 ATOM 2662 C CD1 . LEU A 1 351 ? 1.274 -42.185 -25.064 1.00 27.97 ? 351 LEU A CD1 1 ATOM 2663 C CD2 . LEU A 1 351 ? -0.596 -42.040 -23.445 1.00 27.32 ? 351 LEU A CD2 1 ATOM 2664 N N . LEU A 1 352 ? -2.379 -41.780 -27.917 1.00 31.05 ? 352 LEU A N 1 ATOM 2665 C CA . LEU A 1 352 ? -3.033 -42.851 -28.631 1.00 30.73 ? 352 LEU A CA 1 ATOM 2666 C C . LEU A 1 352 ? -2.508 -42.921 -30.066 1.00 31.27 ? 352 LEU A C 1 ATOM 2667 O O . LEU A 1 352 ? -2.196 -43.993 -30.550 1.00 32.09 ? 352 LEU A O 1 ATOM 2668 C CB . LEU A 1 352 ? -4.546 -42.685 -28.587 1.00 30.38 ? 352 LEU A CB 1 ATOM 2669 C CG . LEU A 1 352 ? -5.405 -43.808 -29.165 1.00 29.22 ? 352 LEU A CG 1 ATOM 2670 C CD1 . LEU A 1 352 ? -4.986 -45.159 -28.643 1.00 29.84 ? 352 LEU A CD1 1 ATOM 2671 C CD2 . LEU A 1 352 ? -6.847 -43.548 -28.865 1.00 27.47 ? 352 LEU A CD2 1 ATOM 2672 N N . GLN A 1 353 ? -2.381 -41.789 -30.749 1.00 31.85 ? 353 GLN A N 1 ATOM 2673 C CA . GLN A 1 353 ? -1.830 -41.810 -32.109 1.00 31.77 ? 353 GLN A CA 1 ATOM 2674 C C . GLN A 1 353 ? -0.502 -42.598 -32.096 1.00 33.08 ? 353 GLN A C 1 ATOM 2675 O O . GLN A 1 353 ? -0.319 -43.530 -32.893 1.00 33.09 ? 353 GLN A O 1 ATOM 2676 C CB . GLN A 1 353 ? -1.584 -40.398 -32.642 1.00 31.16 ? 353 GLN A CB 1 ATOM 2677 C CG . GLN A 1 353 ? -2.792 -39.503 -32.817 1.00 31.11 ? 353 GLN A CG 1 ATOM 2678 C CD . GLN A 1 353 ? -2.380 -38.088 -33.241 1.00 30.69 ? 353 GLN A CD 1 ATOM 2679 O OE1 . GLN A 1 353 ? -1.617 -37.924 -34.172 1.00 30.10 ? 353 GLN A OE1 1 ATOM 2680 N NE2 . GLN A 1 353 ? -2.874 -37.075 -32.546 1.00 27.65 ? 353 GLN A NE2 1 ATOM 2681 N N . ILE A 1 354 ? 0.411 -42.232 -31.175 1.00 33.69 ? 354 ILE A N 1 ATOM 2682 C CA . ILE A 1 354 ? 1.709 -42.890 -31.072 1.00 33.60 ? 354 ILE A CA 1 ATOM 2683 C C . ILE A 1 354 ? 1.485 -44.364 -30.789 1.00 34.18 ? 354 ILE A C 1 ATOM 2684 O O . ILE A 1 354 ? 2.070 -45.206 -31.426 1.00 34.63 ? 354 ILE A O 1 ATOM 2685 C CB . ILE A 1 354 ? 2.613 -42.239 -30.010 1.00 33.39 ? 354 ILE A CB 1 ATOM 2686 C CG1 . ILE A 1 354 ? 2.983 -40.810 -30.444 1.00 33.91 ? 354 ILE A CG1 1 ATOM 2687 C CG2 . ILE A 1 354 ? 3.863 -43.063 -29.822 1.00 33.12 ? 354 ILE A CG2 1 ATOM 2688 C CD1 . ILE A 1 354 ? 3.572 -39.911 -29.384 1.00 31.33 ? 354 ILE A CD1 1 ATOM 2689 N N . LEU A 1 355 ? 0.596 -44.677 -29.859 1.00 34.73 ? 355 LEU A N 1 ATOM 2690 C CA . LEU A 1 355 ? 0.319 -46.073 -29.521 1.00 35.14 ? 355 LEU A CA 1 ATOM 2691 C C . LEU A 1 355 ? -0.350 -46.864 -30.677 1.00 35.97 ? 355 LEU A C 1 ATOM 2692 O O . LEU A 1 355 ? -0.159 -48.069 -30.805 1.00 35.64 ? 355 LEU A O 1 ATOM 2693 C CB . LEU A 1 355 ? -0.507 -46.141 -28.231 1.00 34.40 ? 355 LEU A CB 1 ATOM 2694 C CG . LEU A 1 355 ? 0.187 -45.525 -27.025 1.00 32.84 ? 355 LEU A CG 1 ATOM 2695 C CD1 . LEU A 1 355 ? -0.546 -45.814 -25.706 1.00 31.32 ? 355 LEU A CD1 1 ATOM 2696 C CD2 . LEU A 1 355 ? 1.632 -46.000 -26.958 1.00 31.56 ? 355 LEU A CD2 1 ATOM 2697 N N . SER A 1 356 ? -1.112 -46.170 -31.510 1.00 36.55 ? 356 SER A N 1 ATOM 2698 C CA . SER A 1 356 ? -1.775 -46.783 -32.625 1.00 38.22 ? 356 SER A CA 1 ATOM 2699 C C . SER A 1 356 ? -0.822 -46.948 -33.809 1.00 39.67 ? 356 SER A C 1 ATOM 2700 O O . SER A 1 356 ? -1.232 -47.419 -34.879 1.00 40.48 ? 356 SER A O 1 ATOM 2701 C CB . SER A 1 356 ? -2.972 -45.925 -33.056 1.00 38.54 ? 356 SER A CB 1 ATOM 2702 O OG . SER A 1 356 ? -3.963 -45.865 -32.045 1.00 38.49 ? 356 SER A OG 1 ATOM 2703 N N . GLY A 1 357 ? 0.431 -46.527 -33.632 1.00 40.83 ? 357 GLY A N 1 ATOM 2704 C CA . GLY A 1 357 ? 1.474 -46.705 -34.643 1.00 41.93 ? 357 GLY A CA 1 ATOM 2705 C C . GLY A 1 357 ? 2.061 -45.522 -35.427 1.00 42.70 ? 357 GLY A C 1 ATOM 2706 O O . GLY A 1 357 ? 2.870 -45.750 -36.347 1.00 42.79 ? 357 GLY A O 1 ATOM 2707 N N . ALA A 1 358 ? 1.675 -44.280 -35.107 1.00 42.90 ? 358 ALA A N 1 ATOM 2708 C CA . ALA A 1 358 ? 2.392 -43.092 -35.652 1.00 43.24 ? 358 ALA A CA 1 ATOM 2709 C C . ALA A 1 358 ? 3.860 -43.081 -35.181 1.00 43.26 ? 358 ALA A C 1 ATOM 2710 O O . ALA A 1 358 ? 4.151 -43.405 -34.025 1.00 43.23 ? 358 ALA A O 1 ATOM 2711 C CB . ALA A 1 358 ? 1.679 -41.765 -35.292 1.00 42.99 ? 358 ALA A CB 1 ATOM 2712 N N . GLN A 1 359 ? 4.782 -42.741 -36.075 1.00 43.35 ? 359 GLN A N 1 ATOM 2713 C CA . GLN A 1 359 ? 6.193 -42.981 -35.791 1.00 44.14 ? 359 GLN A CA 1 ATOM 2714 C C . GLN A 1 359 ? 7.065 -41.723 -35.718 1.00 44.19 ? 359 GLN A C 1 ATOM 2715 O O . GLN A 1 359 ? 8.247 -41.800 -35.371 1.00 43.70 ? 359 GLN A O 1 ATOM 2716 C CB . GLN A 1 359 ? 6.789 -43.963 -36.815 1.00 44.41 ? 359 GLN A CB 1 ATOM 2717 C CG . GLN A 1 359 ? 6.179 -45.376 -36.857 1.00 44.79 ? 359 GLN A CG 1 ATOM 2718 C CD . GLN A 1 359 ? 6.733 -46.185 -38.024 1.00 44.83 ? 359 GLN A CD 1 ATOM 2719 O OE1 . GLN A 1 359 ? 6.477 -45.870 -39.183 1.00 42.20 ? 359 GLN A OE1 1 ATOM 2720 N NE2 . GLN A 1 359 ? 7.525 -47.225 -37.713 1.00 47.73 ? 359 GLN A NE2 1 ATOM 2721 N N . SER A 1 360 ? 6.494 -40.570 -36.037 1.00 44.60 ? 360 SER A N 1 ATOM 2722 C CA . SER A 1 360 ? 7.309 -39.365 -36.179 1.00 45.61 ? 360 SER A CA 1 ATOM 2723 C C . SER A 1 360 ? 6.497 -38.090 -35.910 1.00 46.38 ? 360 SER A C 1 ATOM 2724 O O . SER A 1 360 ? 5.266 -38.122 -35.959 1.00 47.09 ? 360 SER A O 1 ATOM 2725 C CB . SER A 1 360 ? 7.894 -39.325 -37.594 1.00 45.02 ? 360 SER A CB 1 ATOM 2726 O OG . SER A 1 360 ? 6.866 -39.072 -38.543 1.00 44.56 ? 360 SER A OG 1 ATOM 2727 N N . ALA A 1 361 ? 7.176 -36.972 -35.658 1.00 47.22 ? 361 ALA A N 1 ATOM 2728 C CA . ALA A 1 361 ? 6.481 -35.679 -35.516 1.00 48.38 ? 361 ALA A CA 1 ATOM 2729 C C . ALA A 1 361 ? 5.585 -35.370 -36.713 1.00 49.11 ? 361 ALA A C 1 ATOM 2730 O O . ALA A 1 361 ? 4.555 -34.684 -36.564 1.00 50.26 ? 361 ALA A O 1 ATOM 2731 C CB . ALA A 1 361 ? 7.464 -34.525 -35.281 1.00 48.00 ? 361 ALA A CB 1 ATOM 2732 N N . GLN A 1 362 ? 5.957 -35.887 -37.884 1.00 49.34 ? 362 GLN A N 1 ATOM 2733 C CA . GLN A 1 362 ? 5.227 -35.595 -39.136 1.00 49.59 ? 362 GLN A CA 1 ATOM 2734 C C . GLN A 1 362 ? 3.885 -36.366 -39.298 1.00 48.86 ? 362 GLN A C 1 ATOM 2735 O O . GLN A 1 362 ? 2.981 -35.895 -39.975 1.00 49.02 ? 362 GLN A O 1 ATOM 2736 C CB . GLN A 1 362 ? 6.155 -35.788 -40.349 1.00 49.35 ? 362 GLN A CB 1 ATOM 2737 C CG . GLN A 1 362 ? 5.734 -34.996 -41.553 1.00 52.48 ? 362 GLN A CG 1 ATOM 2738 C CD . GLN A 1 362 ? 6.203 -35.591 -42.891 1.00 56.11 ? 362 GLN A CD 1 ATOM 2739 O OE1 . GLN A 1 362 ? 5.436 -35.626 -43.862 1.00 56.45 ? 362 GLN A OE1 1 ATOM 2740 N NE2 . GLN A 1 362 ? 7.460 -36.051 -42.947 1.00 56.64 ? 362 GLN A NE2 1 ATOM 2741 N N . ASP A 1 363 ? 3.772 -37.543 -38.677 1.00 48.04 ? 363 ASP A N 1 ATOM 2742 C CA . ASP A 1 363 ? 2.517 -38.314 -38.649 1.00 47.13 ? 363 ASP A CA 1 ATOM 2743 C C . ASP A 1 363 ? 1.599 -37.813 -37.555 1.00 45.88 ? 363 ASP A C 1 ATOM 2744 O O . ASP A 1 363 ? 0.416 -38.149 -37.531 1.00 45.83 ? 363 ASP A O 1 ATOM 2745 C CB . ASP A 1 363 ? 2.769 -39.781 -38.279 1.00 47.86 ? 363 ASP A CB 1 ATOM 2746 C CG . ASP A 1 363 ? 3.685 -40.497 -39.228 1.00 49.01 ? 363 ASP A CG 1 ATOM 2747 O OD1 . ASP A 1 363 ? 3.851 -40.040 -40.386 1.00 50.68 ? 363 ASP A OD1 1 ATOM 2748 O OD2 . ASP A 1 363 ? 4.223 -41.545 -38.792 1.00 50.46 ? 363 ASP A OD2 1 ATOM 2749 N N . LEU A 1 364 ? 2.152 -37.069 -36.607 1.00 44.06 ? 364 LEU A N 1 ATOM 2750 C CA . LEU A 1 364 ? 1.377 -36.669 -35.458 1.00 42.68 ? 364 LEU A CA 1 ATOM 2751 C C . LEU A 1 364 ? 0.465 -35.488 -35.777 1.00 42.30 ? 364 LEU A C 1 ATOM 2752 O O . LEU A 1 364 ? 0.883 -34.542 -36.440 1.00 43.18 ? 364 LEU A O 1 ATOM 2753 C CB . LEU A 1 364 ? 2.284 -36.432 -34.239 1.00 42.21 ? 364 LEU A CB 1 ATOM 2754 C CG . LEU A 1 364 ? 2.863 -37.763 -33.734 1.00 39.97 ? 364 LEU A CG 1 ATOM 2755 C CD1 . LEU A 1 364 ? 3.993 -37.625 -32.757 1.00 37.36 ? 364 LEU A CD1 1 ATOM 2756 C CD2 . LEU A 1 364 ? 1.767 -38.667 -33.187 1.00 37.81 ? 364 LEU A CD2 1 ATOM 2757 N N . LEU A 1 365 ? -0.796 -35.590 -35.358 1.00 40.99 ? 365 LEU A N 1 ATOM 2758 C CA . LEU A 1 365 ? -1.721 -34.475 -35.404 1.00 39.86 ? 365 LEU A CA 1 ATOM 2759 C C . LEU A 1 365 ? -1.802 -33.787 -34.038 1.00 39.25 ? 365 LEU A C 1 ATOM 2760 O O . LEU A 1 365 ? -1.794 -34.462 -33.002 1.00 39.30 ? 365 LEU A O 1 ATOM 2761 C CB . LEU A 1 365 ? -3.099 -34.944 -35.853 1.00 39.64 ? 365 LEU A CB 1 ATOM 2762 C CG . LEU A 1 365 ? -3.312 -35.500 -37.269 1.00 40.18 ? 365 LEU A CG 1 ATOM 2763 C CD1 . LEU A 1 365 ? -4.818 -35.455 -37.584 1.00 40.28 ? 365 LEU A CD1 1 ATOM 2764 C CD2 . LEU A 1 365 ? -2.510 -34.762 -38.349 1.00 38.27 ? 365 LEU A CD2 1 ATOM 2765 N N . PRO A 1 366 ? -1.891 -32.447 -34.019 1.00 38.68 ? 366 PRO A N 1 ATOM 2766 C CA . PRO A 1 366 ? -1.996 -31.533 -35.160 1.00 39.03 ? 366 PRO A CA 1 ATOM 2767 C C . PRO A 1 366 ? -0.659 -31.182 -35.835 1.00 39.34 ? 366 PRO A C 1 ATOM 2768 O O . PRO A 1 366 ? 0.357 -30.962 -35.160 1.00 39.26 ? 366 PRO A O 1 ATOM 2769 C CB . PRO A 1 366 ? -2.631 -30.294 -34.543 1.00 38.98 ? 366 PRO A CB 1 ATOM 2770 C CG . PRO A 1 366 ? -2.145 -30.295 -33.142 1.00 38.40 ? 366 PRO A CG 1 ATOM 2771 C CD . PRO A 1 366 ? -1.899 -31.722 -32.742 1.00 38.09 ? 366 PRO A CD 1 ATOM 2772 N N . SER A 1 367 ? -0.689 -31.107 -37.164 1.00 39.69 ? 367 SER A N 1 ATOM 2773 C CA . SER A 1 367 ? 0.506 -30.853 -37.977 1.00 40.06 ? 367 SER A CA 1 ATOM 2774 C C . SER A 1 367 ? 1.147 -29.537 -37.573 1.00 39.14 ? 367 SER A C 1 ATOM 2775 O O . SER A 1 367 ? 0.448 -28.528 -37.439 1.00 39.34 ? 367 SER A O 1 ATOM 2776 C CB . SER A 1 367 ? 0.131 -30.800 -39.463 1.00 40.48 ? 367 SER A CB 1 ATOM 2777 O OG . SER A 1 367 ? -1.046 -31.561 -39.697 1.00 42.57 ? 367 SER A OG 1 ATOM 2778 N N . GLY A 1 368 ? 2.462 -29.548 -37.379 1.00 37.94 ? 368 GLY A N 1 ATOM 2779 C CA . GLY A 1 368 ? 3.187 -28.332 -37.050 1.00 37.05 ? 368 GLY A CA 1 ATOM 2780 C C . GLY A 1 368 ? 3.227 -28.019 -35.563 1.00 37.12 ? 368 GLY A C 1 ATOM 2781 O O . GLY A 1 368 ? 3.907 -27.088 -35.144 1.00 36.60 ? 368 GLY A O 1 ATOM 2782 N N . SER A 1 369 ? 2.507 -28.788 -34.755 1.00 36.68 ? 369 SER A N 1 ATOM 2783 C CA . SER A 1 369 ? 2.536 -28.559 -33.320 1.00 37.13 ? 369 SER A CA 1 ATOM 2784 C C . SER A 1 369 ? 3.390 -29.568 -32.528 1.00 37.07 ? 369 SER A C 1 ATOM 2785 O O . SER A 1 369 ? 3.643 -29.355 -31.322 1.00 37.35 ? 369 SER A O 1 ATOM 2786 C CB . SER A 1 369 ? 1.115 -28.511 -32.749 1.00 36.82 ? 369 SER A CB 1 ATOM 2787 O OG . SER A 1 369 ? 0.433 -27.416 -33.292 1.00 37.98 ? 369 SER A OG 1 ATOM 2788 N N . VAL A 1 370 ? 3.814 -30.655 -33.182 1.00 36.35 ? 370 VAL A N 1 ATOM 2789 C CA . VAL A 1 370 ? 4.559 -31.723 -32.494 1.00 35.96 ? 370 VAL A CA 1 ATOM 2790 C C . VAL A 1 370 ? 6.016 -31.729 -32.914 1.00 35.53 ? 370 VAL A C 1 ATOM 2791 O O . VAL A 1 370 ? 6.329 -31.648 -34.089 1.00 34.79 ? 370 VAL A O 1 ATOM 2792 C CB . VAL A 1 370 ? 3.916 -33.121 -32.723 1.00 36.07 ? 370 VAL A CB 1 ATOM 2793 C CG1 . VAL A 1 370 ? 4.507 -34.199 -31.792 1.00 35.24 ? 370 VAL A CG1 1 ATOM 2794 C CG2 . VAL A 1 370 ? 2.426 -33.037 -32.497 1.00 37.24 ? 370 VAL A CG2 1 ATOM 2795 N N . TYR A 1 371 ? 6.888 -31.818 -31.917 1.00 35.99 ? 371 TYR A N 1 ATOM 2796 C CA . TYR A 1 371 ? 8.354 -31.866 -32.089 1.00 36.18 ? 371 TYR A CA 1 ATOM 2797 C C . TYR A 1 371 ? 8.886 -33.170 -31.618 1.00 36.45 ? 371 TYR A C 1 ATOM 2798 O O . TYR A 1 371 ? 8.686 -33.543 -30.472 1.00 36.46 ? 371 TYR A O 1 ATOM 2799 C CB . TYR A 1 371 ? 9.045 -30.751 -31.287 1.00 35.17 ? 371 TYR A CB 1 ATOM 2800 C CG . TYR A 1 371 ? 8.761 -29.430 -31.902 1.00 35.58 ? 371 TYR A CG 1 ATOM 2801 C CD1 . TYR A 1 371 ? 9.712 -28.790 -32.702 1.00 36.40 ? 371 TYR A CD1 1 ATOM 2802 C CD2 . TYR A 1 371 ? 7.520 -28.829 -31.735 1.00 34.75 ? 371 TYR A CD2 1 ATOM 2803 C CE1 . TYR A 1 371 ? 9.421 -27.549 -33.304 1.00 36.82 ? 371 TYR A CE1 1 ATOM 2804 C CE2 . TYR A 1 371 ? 7.224 -27.622 -32.336 1.00 36.14 ? 371 TYR A CE2 1 ATOM 2805 C CZ . TYR A 1 371 ? 8.165 -26.991 -33.117 1.00 35.21 ? 371 TYR A CZ 1 ATOM 2806 O OH . TYR A 1 371 ? 7.836 -25.810 -33.699 1.00 34.50 ? 371 TYR A OH 1 ATOM 2807 N N . SER A 1 372 ? 9.602 -33.853 -32.491 1.00 37.58 ? 372 SER A N 1 ATOM 2808 C CA . SER A 1 372 ? 10.193 -35.116 -32.111 1.00 38.76 ? 372 SER A CA 1 ATOM 2809 C C . SER A 1 372 ? 11.474 -34.856 -31.335 1.00 38.95 ? 372 SER A C 1 ATOM 2810 O O . SER A 1 372 ? 12.280 -34.006 -31.719 1.00 40.01 ? 372 SER A O 1 ATOM 2811 C CB . SER A 1 372 ? 10.492 -35.958 -33.333 1.00 39.03 ? 372 SER A CB 1 ATOM 2812 O OG . SER A 1 372 ? 10.756 -37.286 -32.915 1.00 43.31 ? 372 SER A OG 1 ATOM 2813 N N . LEU A 1 373 ? 11.660 -35.598 -30.250 1.00 38.71 ? 373 LEU A N 1 ATOM 2814 C CA . LEU A 1 373 ? 12.852 -35.498 -29.407 1.00 37.87 ? 373 LEU A CA 1 ATOM 2815 C C . LEU A 1 373 ? 13.551 -36.864 -29.267 1.00 38.03 ? 373 LEU A C 1 ATOM 2816 O O . LEU A 1 373 ? 12.880 -37.888 -29.027 1.00 37.68 ? 373 LEU A O 1 ATOM 2817 C CB . LEU A 1 373 ? 12.482 -34.948 -28.035 1.00 36.86 ? 373 LEU A CB 1 ATOM 2818 C CG . LEU A 1 373 ? 11.954 -33.518 -27.975 1.00 36.50 ? 373 LEU A CG 1 ATOM 2819 C CD1 . LEU A 1 373 ? 11.884 -33.101 -26.509 1.00 36.21 ? 373 LEU A CD1 1 ATOM 2820 C CD2 . LEU A 1 373 ? 12.821 -32.552 -28.754 1.00 32.79 ? 373 LEU A CD2 1 ATOM 2821 N N . PRO A 1 374 ? 14.895 -36.891 -29.433 1.00 37.58 ? 374 PRO A N 1 ATOM 2822 C CA . PRO A 1 374 ? 15.604 -38.139 -29.319 1.00 37.66 ? 374 PRO A CA 1 ATOM 2823 C C . PRO A 1 374 ? 15.829 -38.524 -27.857 1.00 37.77 ? 374 PRO A C 1 ATOM 2824 O O . PRO A 1 374 ? 15.772 -37.664 -26.987 1.00 37.68 ? 374 PRO A O 1 ATOM 2825 C CB . PRO A 1 374 ? 16.923 -37.840 -30.024 1.00 37.87 ? 374 PRO A CB 1 ATOM 2826 C CG . PRO A 1 374 ? 17.164 -36.420 -29.792 1.00 37.25 ? 374 PRO A CG 1 ATOM 2827 C CD . PRO A 1 374 ? 15.803 -35.784 -29.767 1.00 37.78 ? 374 PRO A CD 1 ATOM 2828 N N . ALA A 1 375 ? 16.090 -39.810 -27.617 1.00 37.85 ? 375 ALA A N 1 ATOM 2829 C CA . ALA A 1 375 ? 16.307 -40.358 -26.275 1.00 38.06 ? 375 ALA A CA 1 ATOM 2830 C C . ALA A 1 375 ? 17.660 -39.973 -25.696 1.00 38.10 ? 375 ALA A C 1 ATOM 2831 O O . ALA A 1 375 ? 18.637 -39.847 -26.432 1.00 37.81 ? 375 ALA A O 1 ATOM 2832 C CB . ALA A 1 375 ? 16.166 -41.899 -26.298 1.00 37.90 ? 375 ALA A CB 1 ATOM 2833 N N . ASN A 1 376 ? 17.691 -39.809 -24.372 1.00 38.68 ? 376 ASN A N 1 ATOM 2834 C CA . ASN A 1 376 ? 18.918 -39.538 -23.596 1.00 38.79 ? 376 ASN A CA 1 ATOM 2835 C C . ASN A 1 376 ? 19.789 -38.438 -24.208 1.00 38.06 ? 376 ASN A C 1 ATOM 2836 O O . ASN A 1 376 ? 20.959 -38.645 -24.449 1.00 39.40 ? 376 ASN A O 1 ATOM 2837 C CB . ASN A 1 376 ? 19.703 -40.847 -23.391 1.00 39.01 ? 376 ASN A CB 1 ATOM 2838 C CG . ASN A 1 376 ? 18.816 -41.997 -22.831 1.00 41.14 ? 376 ASN A CG 1 ATOM 2839 O OD1 . ASN A 1 376 ? 18.300 -41.928 -21.704 1.00 42.83 ? 376 ASN A OD1 1 ATOM 2840 N ND2 . ASN A 1 376 ? 18.641 -43.048 -23.628 1.00 42.01 ? 376 ASN A ND2 1 ATOM 2841 N N . ALA A 1 377 ? 19.192 -37.283 -24.481 1.00 37.00 ? 377 ALA A N 1 ATOM 2842 C CA . ALA A 1 377 ? 19.858 -36.122 -25.099 1.00 35.78 ? 377 ALA A CA 1 ATOM 2843 C C . ALA A 1 377 ? 19.675 -34.845 -24.263 1.00 35.01 ? 377 ALA A C 1 ATOM 2844 O O . ALA A 1 377 ? 18.719 -34.749 -23.496 1.00 34.77 ? 377 ALA A O 1 ATOM 2845 C CB . ALA A 1 377 ? 19.302 -35.893 -26.478 1.00 35.61 ? 377 ALA A CB 1 ATOM 2846 N N . ASP A 1 378 ? 20.597 -33.891 -24.399 1.00 34.29 ? 378 ASP A N 1 ATOM 2847 C CA . ASP A 1 378 ? 20.492 -32.605 -23.717 1.00 34.30 ? 378 ASP A CA 1 ATOM 2848 C C . ASP A 1 378 ? 19.774 -31.693 -24.666 1.00 33.40 ? 378 ASP A C 1 ATOM 2849 O O . ASP A 1 378 ? 20.202 -31.543 -25.827 1.00 33.63 ? 378 ASP A O 1 ATOM 2850 C CB . ASP A 1 378 ? 21.864 -31.974 -23.438 1.00 35.01 ? 378 ASP A CB 1 ATOM 2851 C CG . ASP A 1 378 ? 22.768 -32.833 -22.575 1.00 36.80 ? 378 ASP A CG 1 ATOM 2852 O OD1 . ASP A 1 378 ? 22.289 -33.628 -21.717 1.00 38.47 ? 378 ASP A OD1 1 ATOM 2853 O OD2 . ASP A 1 378 ? 23.997 -32.680 -22.758 1.00 39.46 ? 378 ASP A OD2 1 ATOM 2854 N N . ILE A 1 379 ? 18.693 -31.085 -24.202 1.00 31.83 ? 379 ILE A N 1 ATOM 2855 C CA . ILE A 1 379 ? 17.871 -30.264 -25.098 1.00 31.58 ? 379 ILE A CA 1 ATOM 2856 C C . ILE A 1 379 ? 17.849 -28.822 -24.645 1.00 31.46 ? 379 ILE A C 1 ATOM 2857 O O . ILE A 1 379 ? 17.753 -28.562 -23.450 1.00 31.57 ? 379 ILE A O 1 ATOM 2858 C CB . ILE A 1 379 ? 16.413 -30.769 -25.156 1.00 31.52 ? 379 ILE A CB 1 ATOM 2859 C CG1 . ILE A 1 379 ? 16.359 -32.310 -25.362 1.00 30.47 ? 379 ILE A CG1 1 ATOM 2860 C CG2 . ILE A 1 379 ? 15.581 -29.913 -26.143 1.00 29.73 ? 379 ILE A CG2 1 ATOM 2861 C CD1 . ILE A 1 379 ? 16.533 -32.852 -26.819 1.00 26.43 ? 379 ILE A CD1 1 ATOM 2862 N N . GLU A 1 380 ? 17.957 -27.888 -25.587 1.00 31.69 ? 380 GLU A N 1 ATOM 2863 C CA . GLU A 1 380 ? 17.823 -26.455 -25.255 1.00 31.51 ? 380 GLU A CA 1 ATOM 2864 C C . GLU A 1 380 ? 16.676 -25.788 -25.992 1.00 31.29 ? 380 GLU A C 1 ATOM 2865 O O . GLU A 1 380 ? 16.571 -25.877 -27.230 1.00 31.35 ? 380 GLU A O 1 ATOM 2866 C CB . GLU A 1 380 ? 19.105 -25.693 -25.532 1.00 31.39 ? 380 GLU A CB 1 ATOM 2867 C CG . GLU A 1 380 ? 19.012 -24.213 -25.184 1.00 32.42 ? 380 GLU A CG 1 ATOM 2868 C CD . GLU A 1 380 ? 20.372 -23.539 -25.163 1.00 33.84 ? 380 GLU A CD 1 ATOM 2869 O OE1 . GLU A 1 380 ? 20.973 -23.430 -24.062 1.00 32.92 ? 380 GLU A OE1 1 ATOM 2870 O OE2 . GLU A 1 380 ? 20.843 -23.137 -26.253 1.00 34.90 ? 380 GLU A OE2 1 ATOM 2871 N N . ILE A 1 381 ? 15.814 -25.123 -25.231 1.00 30.96 ? 381 ILE A N 1 ATOM 2872 C CA . ILE A 1 381 ? 14.676 -24.416 -25.817 1.00 30.42 ? 381 ILE A CA 1 ATOM 2873 C C . ILE A 1 381 ? 14.682 -22.920 -25.441 1.00 31.01 ? 381 ILE A C 1 ATOM 2874 O O . ILE A 1 381 ? 14.794 -22.536 -24.270 1.00 30.87 ? 381 ILE A O 1 ATOM 2875 C CB . ILE A 1 381 ? 13.349 -25.119 -25.499 1.00 30.08 ? 381 ILE A CB 1 ATOM 2876 C CG1 . ILE A 1 381 ? 13.360 -26.536 -26.113 1.00 29.82 ? 381 ILE A CG1 1 ATOM 2877 C CG2 . ILE A 1 381 ? 12.183 -24.299 -26.032 1.00 30.97 ? 381 ILE A CG2 1 ATOM 2878 C CD1 . ILE A 1 381 ? 12.162 -27.430 -25.820 1.00 28.89 ? 381 ILE A CD1 1 ATOM 2879 N N . SER A 1 382 ? 14.624 -22.076 -26.462 1.00 31.27 ? 382 SER A N 1 ATOM 2880 C CA . SER A 1 382 ? 14.557 -20.638 -26.237 1.00 31.54 ? 382 SER A CA 1 ATOM 2881 C C . SER A 1 382 ? 13.178 -20.126 -26.669 1.00 31.28 ? 382 SER A C 1 ATOM 2882 O O . SER A 1 382 ? 12.597 -20.602 -27.638 1.00 32.05 ? 382 SER A O 1 ATOM 2883 C CB . SER A 1 382 ? 15.669 -19.937 -26.983 1.00 30.98 ? 382 SER A CB 1 ATOM 2884 O OG . SER A 1 382 ? 15.606 -20.340 -28.327 1.00 32.92 ? 382 SER A OG 1 ATOM 2885 N N . LEU A 1 383 ? 12.655 -19.178 -25.914 1.00 30.67 ? 383 LEU A N 1 ATOM 2886 C CA . LEU A 1 383 ? 11.285 -18.745 -26.057 1.00 30.70 ? 383 LEU A CA 1 ATOM 2887 C C . LEU A 1 383 ? 11.309 -17.224 -25.960 1.00 30.34 ? 383 LEU A C 1 ATOM 2888 O O . LEU A 1 383 ? 10.857 -16.663 -24.954 1.00 29.99 ? 383 LEU A O 1 ATOM 2889 C CB . LEU A 1 383 ? 10.422 -19.348 -24.946 1.00 30.23 ? 383 LEU A CB 1 ATOM 2890 C CG . LEU A 1 383 ? 10.474 -20.863 -24.764 1.00 29.28 ? 383 LEU A CG 1 ATOM 2891 C CD1 . LEU A 1 383 ? 10.929 -21.198 -23.394 1.00 26.23 ? 383 LEU A CD1 1 ATOM 2892 C CD2 . LEU A 1 383 ? 9.116 -21.513 -25.051 1.00 27.59 ? 383 LEU A CD2 1 ATOM 2893 N N . PRO A 1 384 ? 11.868 -16.554 -26.998 1.00 30.31 ? 384 PRO A N 1 ATOM 2894 C CA . PRO A 1 384 ? 12.065 -15.096 -26.936 1.00 30.45 ? 384 PRO A CA 1 ATOM 2895 C C . PRO A 1 384 ? 10.723 -14.347 -26.807 1.00 30.93 ? 384 PRO A C 1 ATOM 2896 O O . PRO A 1 384 ? 9.824 -14.562 -27.616 1.00 30.32 ? 384 PRO A O 1 ATOM 2897 C CB . PRO A 1 384 ? 12.765 -14.784 -28.274 1.00 30.51 ? 384 PRO A CB 1 ATOM 2898 C CG . PRO A 1 384 ? 12.382 -15.919 -29.188 1.00 29.22 ? 384 PRO A CG 1 ATOM 2899 C CD . PRO A 1 384 ? 12.302 -17.117 -28.297 1.00 29.93 ? 384 PRO A CD 1 ATOM 2900 N N . ALA A 1 385 ? 10.600 -13.505 -25.779 1.00 31.59 ? 385 ALA A N 1 ATOM 2901 C CA . ALA A 1 385 ? 9.425 -12.649 -25.569 1.00 32.53 ? 385 ALA A CA 1 ATOM 2902 C C . ALA A 1 385 ? 9.137 -11.760 -26.780 1.00 33.22 ? 385 ALA A C 1 ATOM 2903 O O . ALA A 1 385 ? 10.068 -11.263 -27.432 1.00 33.97 ? 385 ALA A O 1 ATOM 2904 C CB . ALA A 1 385 ? 9.642 -11.766 -24.346 1.00 32.22 ? 385 ALA A CB 1 ATOM 2905 N N . THR A 1 386 ? 7.857 -11.545 -27.072 1.00 33.06 ? 386 THR A N 1 ATOM 2906 C CA . THR A 1 386 ? 7.457 -10.662 -28.159 1.00 32.80 ? 386 THR A CA 1 ATOM 2907 C C . THR A 1 386 ? 6.029 -10.187 -27.971 1.00 33.12 ? 386 THR A C 1 ATOM 2908 O O . THR A 1 386 ? 5.167 -10.953 -27.536 1.00 33.63 ? 386 THR A O 1 ATOM 2909 C CB . THR A 1 386 ? 7.604 -11.324 -29.529 1.00 32.90 ? 386 THR A CB 1 ATOM 2910 O OG1 . THR A 1 386 ? 7.183 -10.409 -30.543 1.00 33.80 ? 386 THR A OG1 1 ATOM 2911 C CG2 . THR A 1 386 ? 6.773 -12.594 -29.638 1.00 32.10 ? 386 THR A CG2 1 ATOM 2912 N N . ALA A 1 387 ? 5.781 -8.913 -28.276 1.00 33.09 ? 387 ALA A N 1 ATOM 2913 C CA . ALA A 1 387 ? 4.451 -8.338 -28.145 1.00 32.26 ? 387 ALA A CA 1 ATOM 2914 C C . ALA A 1 387 ? 3.577 -8.885 -29.281 1.00 32.19 ? 387 ALA A C 1 ATOM 2915 O O . ALA A 1 387 ? 2.365 -8.686 -29.299 1.00 32.36 ? 387 ALA A O 1 ATOM 2916 C CB . ALA A 1 387 ? 4.526 -6.844 -28.179 1.00 31.91 ? 387 ALA A CB 1 ATOM 2917 N N . ALA A 1 388 ? 4.203 -9.585 -30.225 1.00 31.61 ? 388 ALA A N 1 ATOM 2918 C CA . ALA A 1 388 ? 3.473 -10.274 -31.299 1.00 31.62 ? 388 ALA A CA 1 ATOM 2919 C C . ALA A 1 388 ? 2.513 -11.348 -30.751 1.00 31.01 ? 388 ALA A C 1 ATOM 2920 O O . ALA A 1 388 ? 1.667 -11.851 -31.474 1.00 31.01 ? 388 ALA A O 1 ATOM 2921 C CB . ALA A 1 388 ? 4.466 -10.906 -32.307 1.00 31.35 ? 388 ALA A CB 1 ATOM 2922 N N . ALA A 1 389 ? 2.698 -11.705 -29.483 1.00 30.50 ? 389 ALA A N 1 ATOM 2923 C CA . ALA A 1 389 ? 1.826 -12.611 -28.767 1.00 30.73 ? 389 ALA A CA 1 ATOM 2924 C C . ALA A 1 389 ? 1.198 -11.839 -27.608 1.00 30.74 ? 389 ALA A C 1 ATOM 2925 O O . ALA A 1 389 ? 1.835 -11.629 -26.587 1.00 31.77 ? 389 ALA A O 1 ATOM 2926 C CB . ALA A 1 389 ? 2.618 -13.804 -28.260 1.00 30.55 ? 389 ALA A CB 1 ATOM 2927 N N . PRO A 1 390 ? -0.053 -11.408 -27.747 1.00 30.84 ? 390 PRO A N 1 ATOM 2928 C CA . PRO A 1 390 ? -0.594 -10.538 -26.722 1.00 31.36 ? 390 PRO A CA 1 ATOM 2929 C C . PRO A 1 390 ? -0.693 -11.182 -25.330 1.00 31.07 ? 390 PRO A C 1 ATOM 2930 O O . PRO A 1 390 ? -0.830 -12.387 -25.220 1.00 31.36 ? 390 PRO A O 1 ATOM 2931 C CB . PRO A 1 390 ? -2.005 -10.206 -27.226 1.00 31.71 ? 390 PRO A CB 1 ATOM 2932 C CG . PRO A 1 390 ? -2.175 -10.839 -28.501 1.00 31.92 ? 390 PRO A CG 1 ATOM 2933 C CD . PRO A 1 390 ? -1.021 -11.714 -28.807 1.00 31.47 ? 390 PRO A CD 1 ATOM 2934 N N . GLY A 1 391 ? -0.645 -10.369 -24.279 1.00 31.24 ? 391 GLY A N 1 ATOM 2935 C CA . GLY A 1 391 ? -0.929 -10.845 -22.917 1.00 31.00 ? 391 GLY A CA 1 ATOM 2936 C C . GLY A 1 391 ? 0.299 -11.485 -22.294 1.00 31.27 ? 391 GLY A C 1 ATOM 2937 O O . GLY A 1 391 ? 0.172 -12.288 -21.370 1.00 31.38 ? 391 GLY A O 1 ATOM 2938 N N . PHE A 1 392 ? 1.474 -11.155 -22.852 1.00 30.49 ? 392 PHE A N 1 ATOM 2939 C CA . PHE A 1 392 ? 2.782 -11.405 -22.250 1.00 29.51 ? 392 PHE A CA 1 ATOM 2940 C C . PHE A 1 392 ? 2.789 -10.601 -20.967 1.00 28.98 ? 392 PHE A C 1 ATOM 2941 O O . PHE A 1 392 ? 1.992 -9.683 -20.865 1.00 29.79 ? 392 PHE A O 1 ATOM 2942 C CB . PHE A 1 392 ? 3.908 -10.907 -23.187 1.00 29.43 ? 392 PHE A CB 1 ATOM 2943 C CG . PHE A 1 392 ? 3.864 -9.413 -23.477 1.00 27.90 ? 392 PHE A CG 1 ATOM 2944 C CD1 . PHE A 1 392 ? 4.507 -8.509 -22.643 1.00 26.77 ? 392 PHE A CD1 1 ATOM 2945 C CD2 . PHE A 1 392 ? 3.175 -8.923 -24.589 1.00 26.39 ? 392 PHE A CD2 1 ATOM 2946 C CE1 . PHE A 1 392 ? 4.462 -7.119 -22.905 1.00 28.32 ? 392 PHE A CE1 1 ATOM 2947 C CE2 . PHE A 1 392 ? 3.119 -7.548 -24.868 1.00 25.05 ? 392 PHE A CE2 1 ATOM 2948 C CZ . PHE A 1 392 ? 3.762 -6.646 -24.031 1.00 27.68 ? 392 PHE A CZ 1 ATOM 2949 N N . PRO A 1 393 ? 3.644 -10.945 -19.969 1.00 27.81 ? 393 PRO A N 1 ATOM 2950 C CA . PRO A 1 393 ? 4.573 -12.081 -19.820 1.00 26.85 ? 393 PRO A CA 1 ATOM 2951 C C . PRO A 1 393 ? 3.840 -13.432 -19.734 1.00 26.13 ? 393 PRO A C 1 ATOM 2952 O O . PRO A 1 393 ? 3.047 -13.651 -18.822 1.00 26.84 ? 393 PRO A O 1 ATOM 2953 C CB . PRO A 1 393 ? 5.259 -11.787 -18.468 1.00 26.95 ? 393 PRO A CB 1 ATOM 2954 C CG . PRO A 1 393 ? 4.294 -10.881 -17.733 1.00 26.52 ? 393 PRO A CG 1 ATOM 2955 C CD . PRO A 1 393 ? 3.659 -10.060 -18.785 1.00 27.07 ? 393 PRO A CD 1 ATOM 2956 N N . HIS A 1 394 ? 4.108 -14.319 -20.672 1.00 25.11 ? 394 HIS A N 1 ATOM 2957 C CA . HIS A 1 394 ? 3.517 -15.648 -20.729 1.00 24.87 ? 394 HIS A CA 1 ATOM 2958 C C . HIS A 1 394 ? 4.290 -16.706 -19.910 1.00 24.55 ? 394 HIS A C 1 ATOM 2959 O O . HIS A 1 394 ? 5.410 -17.047 -20.292 1.00 24.63 ? 394 HIS A O 1 ATOM 2960 C CB . HIS A 1 394 ? 3.572 -16.140 -22.171 1.00 24.74 ? 394 HIS A CB 1 ATOM 2961 C CG . HIS A 1 394 ? 2.851 -15.284 -23.146 1.00 25.45 ? 394 HIS A CG 1 ATOM 2962 N ND1 . HIS A 1 394 ? 1.519 -15.467 -23.451 1.00 28.46 ? 394 HIS A ND1 1 ATOM 2963 C CD2 . HIS A 1 394 ? 3.290 -14.287 -23.947 1.00 27.78 ? 394 HIS A CD2 1 ATOM 2964 C CE1 . HIS A 1 394 ? 1.157 -14.588 -24.370 1.00 29.59 ? 394 HIS A CE1 1 ATOM 2965 N NE2 . HIS A 1 394 ? 2.214 -13.859 -24.689 1.00 28.43 ? 394 HIS A NE2 1 ATOM 2966 N N . PRO A 1 395 ? 3.688 -17.286 -18.837 1.00 23.99 ? 395 PRO A N 1 ATOM 2967 C CA . PRO A 1 395 ? 4.404 -18.366 -18.126 1.00 23.51 ? 395 PRO A CA 1 ATOM 2968 C C . PRO A 1 395 ? 4.307 -19.738 -18.824 1.00 23.85 ? 395 PRO A C 1 ATOM 2969 O O . PRO A 1 395 ? 3.274 -20.418 -18.753 1.00 24.28 ? 395 PRO A O 1 ATOM 2970 C CB . PRO A 1 395 ? 3.725 -18.408 -16.769 1.00 22.52 ? 395 PRO A CB 1 ATOM 2971 C CG . PRO A 1 395 ? 2.391 -17.820 -16.966 1.00 22.37 ? 395 PRO A CG 1 ATOM 2972 C CD . PRO A 1 395 ? 2.375 -17.013 -18.232 1.00 23.60 ? 395 PRO A CD 1 ATOM 2973 N N . PHE A 1 396 ? 5.382 -20.139 -19.491 1.00 23.88 ? 396 PHE A N 1 ATOM 2974 C CA . PHE A 1 396 ? 5.419 -21.446 -20.173 1.00 24.16 ? 396 PHE A CA 1 ATOM 2975 C C . PHE A 1 396 ? 5.693 -22.606 -19.247 1.00 24.47 ? 396 PHE A C 1 ATOM 2976 O O . PHE A 1 396 ? 6.436 -22.471 -18.247 1.00 26.13 ? 396 PHE A O 1 ATOM 2977 C CB . PHE A 1 396 ? 6.344 -21.432 -21.388 1.00 23.32 ? 396 PHE A CB 1 ATOM 2978 C CG . PHE A 1 396 ? 5.620 -21.070 -22.646 1.00 23.79 ? 396 PHE A CG 1 ATOM 2979 C CD1 . PHE A 1 396 ? 5.147 -19.784 -22.838 1.00 21.17 ? 396 PHE A CD1 1 ATOM 2980 C CD2 . PHE A 1 396 ? 5.337 -22.036 -23.607 1.00 24.20 ? 396 PHE A CD2 1 ATOM 2981 C CE1 . PHE A 1 396 ? 4.429 -19.450 -23.974 1.00 22.73 ? 396 PHE A CE1 1 ATOM 2982 C CE2 . PHE A 1 396 ? 4.624 -21.696 -24.778 1.00 24.12 ? 396 PHE A CE2 1 ATOM 2983 C CZ . PHE A 1 396 ? 4.172 -20.397 -24.956 1.00 23.63 ? 396 PHE A CZ 1 ATOM 2984 N N . HIS A 1 397 ? 5.072 -23.736 -19.554 1.00 24.21 ? 397 HIS A N 1 ATOM 2985 C CA . HIS A 1 397 ? 5.138 -24.891 -18.677 1.00 24.67 ? 397 HIS A CA 1 ATOM 2986 C C . HIS A 1 397 ? 5.462 -26.131 -19.493 1.00 24.95 ? 397 HIS A C 1 ATOM 2987 O O . HIS A 1 397 ? 4.856 -26.349 -20.556 1.00 25.21 ? 397 HIS A O 1 ATOM 2988 C CB . HIS A 1 397 ? 3.803 -25.031 -17.947 1.00 24.99 ? 397 HIS A CB 1 ATOM 2989 C CG . HIS A 1 397 ? 3.642 -26.323 -17.224 1.00 26.75 ? 397 HIS A CG 1 ATOM 2990 N ND1 . HIS A 1 397 ? 4.546 -26.767 -16.279 1.00 29.96 ? 397 HIS A ND1 1 ATOM 2991 C CD2 . HIS A 1 397 ? 2.682 -27.274 -17.301 1.00 28.38 ? 397 HIS A CD2 1 ATOM 2992 C CE1 . HIS A 1 397 ? 4.160 -27.941 -15.810 1.00 28.81 ? 397 HIS A CE1 1 ATOM 2993 N NE2 . HIS A 1 397 ? 3.025 -28.267 -16.409 1.00 30.99 ? 397 HIS A NE2 1 ATOM 2994 N N . LEU A 1 398 ? 6.414 -26.943 -19.022 1.00 25.17 ? 398 LEU A N 1 ATOM 2995 C CA . LEU A 1 398 ? 6.746 -28.194 -19.709 1.00 25.14 ? 398 LEU A CA 1 ATOM 2996 C C . LEU A 1 398 ? 6.295 -29.326 -18.849 1.00 26.02 ? 398 LEU A C 1 ATOM 2997 O O . LEU A 1 398 ? 6.722 -29.439 -17.706 1.00 26.81 ? 398 LEU A O 1 ATOM 2998 C CB . LEU A 1 398 ? 8.255 -28.320 -19.978 1.00 25.20 ? 398 LEU A CB 1 ATOM 2999 C CG . LEU A 1 398 ? 8.783 -29.690 -20.469 1.00 24.92 ? 398 LEU A CG 1 ATOM 3000 C CD1 . LEU A 1 398 ? 8.394 -29.938 -21.910 1.00 23.36 ? 398 LEU A CD1 1 ATOM 3001 C CD2 . LEU A 1 398 ? 10.328 -29.830 -20.317 1.00 24.34 ? 398 LEU A CD2 1 ATOM 3002 N N . HIS A 1 399 ? 5.412 -30.158 -19.386 1.00 27.09 ? 399 HIS A N 1 ATOM 3003 C CA . HIS A 1 399 ? 4.981 -31.422 -18.735 1.00 27.12 ? 399 HIS A CA 1 ATOM 3004 C C . HIS A 1 399 ? 6.129 -32.411 -18.685 1.00 27.30 ? 399 HIS A C 1 ATOM 3005 O O . HIS A 1 399 ? 7.101 -32.254 -19.413 1.00 26.89 ? 399 HIS A O 1 ATOM 3006 C CB . HIS A 1 399 ? 3.770 -32.026 -19.469 1.00 27.24 ? 399 HIS A CB 1 ATOM 3007 C CG . HIS A 1 399 ? 2.492 -31.283 -19.224 1.00 26.54 ? 399 HIS A CG 1 ATOM 3008 N ND1 . HIS A 1 399 ? 1.363 -31.892 -18.714 1.00 25.00 ? 399 HIS A ND1 1 ATOM 3009 C CD2 . HIS A 1 399 ? 2.189 -29.967 -19.346 1.00 25.63 ? 399 HIS A CD2 1 ATOM 3010 C CE1 . HIS A 1 399 ? 0.406 -30.993 -18.562 1.00 24.15 ? 399 HIS A CE1 1 ATOM 3011 N NE2 . HIS A 1 399 ? 0.880 -29.816 -18.937 1.00 28.01 ? 399 HIS A NE2 1 ATOM 3012 N N . GLY A 1 400 ? 6.051 -33.364 -17.757 1.00 27.99 ? 400 GLY A N 1 ATOM 3013 C CA . GLY A 1 400 ? 6.979 -34.494 -17.709 1.00 28.84 ? 400 GLY A CA 1 ATOM 3014 C C . GLY A 1 400 ? 8.413 -34.247 -17.306 1.00 29.47 ? 400 GLY A C 1 ATOM 3015 O O . GLY A 1 400 ? 9.213 -35.187 -17.280 1.00 29.95 ? 400 GLY A O 1 ATOM 3016 N N . HIS A 1 401 ? 8.741 -33.000 -16.972 1.00 29.53 ? 401 HIS A N 1 ATOM 3017 C CA . HIS A 1 401 ? 10.122 -32.594 -16.725 1.00 29.70 ? 401 HIS A CA 1 ATOM 3018 C C . HIS A 1 401 ? 10.211 -31.430 -15.801 1.00 29.63 ? 401 HIS A C 1 ATOM 3019 O O . HIS A 1 401 ? 9.291 -30.643 -15.732 1.00 30.33 ? 401 HIS A O 1 ATOM 3020 C CB . HIS A 1 401 ? 10.815 -32.178 -18.038 1.00 29.83 ? 401 HIS A CB 1 ATOM 3021 C CG . HIS A 1 401 ? 10.978 -33.298 -19.025 1.00 30.16 ? 401 HIS A CG 1 ATOM 3022 N ND1 . HIS A 1 401 ? 11.959 -34.265 -18.899 1.00 29.49 ? 401 HIS A ND1 1 ATOM 3023 C CD2 . HIS A 1 401 ? 10.291 -33.598 -20.152 1.00 29.32 ? 401 HIS A CD2 1 ATOM 3024 C CE1 . HIS A 1 401 ? 11.868 -35.110 -19.909 1.00 30.21 ? 401 HIS A CE1 1 ATOM 3025 N NE2 . HIS A 1 401 ? 10.866 -34.726 -20.685 1.00 32.19 ? 401 HIS A NE2 1 ATOM 3026 N N . THR A 1 402 ? 11.337 -31.310 -15.105 1.00 30.16 ? 402 THR A N 1 ATOM 3027 C CA . THR A 1 402 ? 11.784 -30.023 -14.518 1.00 30.07 ? 402 THR A CA 1 ATOM 3028 C C . THR A 1 402 ? 12.918 -29.558 -15.399 1.00 29.00 ? 402 THR A C 1 ATOM 3029 O O . THR A 1 402 ? 13.639 -30.379 -15.938 1.00 29.95 ? 402 THR A O 1 ATOM 3030 C CB . THR A 1 402 ? 12.297 -30.214 -13.092 1.00 30.63 ? 402 THR A CB 1 ATOM 3031 O OG1 . THR A 1 402 ? 11.342 -29.684 -12.168 1.00 33.48 ? 402 THR A OG1 1 ATOM 3032 C CG2 . THR A 1 402 ? 13.593 -29.524 -12.875 1.00 30.80 ? 402 THR A CG2 1 ATOM 3033 N N . PHE A 1 403 ? 13.064 -28.268 -15.609 1.00 27.21 ? 403 PHE A N 1 ATOM 3034 C CA . PHE A 1 403 ? 14.111 -27.832 -16.500 1.00 25.60 ? 403 PHE A CA 1 ATOM 3035 C C . PHE A 1 403 ? 14.980 -26.812 -15.807 1.00 25.26 ? 403 PHE A C 1 ATOM 3036 O O . PHE A 1 403 ? 14.521 -26.095 -14.914 1.00 25.79 ? 403 PHE A O 1 ATOM 3037 C CB . PHE A 1 403 ? 13.523 -27.275 -17.809 1.00 25.10 ? 403 PHE A CB 1 ATOM 3038 C CG . PHE A 1 403 ? 12.384 -26.338 -17.601 1.00 24.38 ? 403 PHE A CG 1 ATOM 3039 C CD1 . PHE A 1 403 ? 12.612 -25.019 -17.170 1.00 24.50 ? 403 PHE A CD1 1 ATOM 3040 C CD2 . PHE A 1 403 ? 11.066 -26.780 -17.774 1.00 22.43 ? 403 PHE A CD2 1 ATOM 3041 C CE1 . PHE A 1 403 ? 11.522 -24.125 -16.933 1.00 23.97 ? 403 PHE A CE1 1 ATOM 3042 C CE2 . PHE A 1 403 ? 9.978 -25.917 -17.551 1.00 20.97 ? 403 PHE A CE2 1 ATOM 3043 C CZ . PHE A 1 403 ? 10.201 -24.586 -17.126 1.00 23.05 ? 403 PHE A CZ 1 ATOM 3044 N N . ALA A 1 404 ? 16.241 -26.737 -16.219 1.00 24.78 ? 404 ALA A N 1 ATOM 3045 C CA . ALA A 1 404 ? 17.131 -25.648 -15.788 1.00 24.01 ? 404 ALA A CA 1 ATOM 3046 C C . ALA A 1 404 ? 16.724 -24.354 -16.477 1.00 23.75 ? 404 ALA A C 1 ATOM 3047 O O . ALA A 1 404 ? 16.552 -24.342 -17.690 1.00 23.97 ? 404 ALA A O 1 ATOM 3048 C CB . ALA A 1 404 ? 18.559 -25.978 -16.122 1.00 22.85 ? 404 ALA A CB 1 ATOM 3049 N N . VAL A 1 405 ? 16.537 -23.271 -15.727 1.00 24.36 ? 405 VAL A N 1 ATOM 3050 C CA . VAL A 1 405 ? 16.294 -21.964 -16.382 1.00 24.79 ? 405 VAL A CA 1 ATOM 3051 C C . VAL A 1 405 ? 17.625 -21.263 -16.644 1.00 26.23 ? 405 VAL A C 1 ATOM 3052 O O . VAL A 1 405 ? 18.165 -20.543 -15.778 1.00 26.33 ? 405 VAL A O 1 ATOM 3053 C CB . VAL A 1 405 ? 15.339 -21.033 -15.596 1.00 24.49 ? 405 VAL A CB 1 ATOM 3054 C CG1 . VAL A 1 405 ? 15.160 -19.735 -16.353 1.00 22.33 ? 405 VAL A CG1 1 ATOM 3055 C CG2 . VAL A 1 405 ? 13.985 -21.715 -15.331 1.00 21.53 ? 405 VAL A CG2 1 ATOM 3056 N N . VAL A 1 406 ? 18.152 -21.460 -17.849 1.00 27.22 ? 406 VAL A N 1 ATOM 3057 C CA . VAL A 1 406 ? 19.467 -20.922 -18.172 1.00 28.20 ? 406 VAL A CA 1 ATOM 3058 C C . VAL A 1 406 ? 19.500 -19.383 -18.249 1.00 29.10 ? 406 VAL A C 1 ATOM 3059 O O . VAL A 1 406 ? 20.515 -18.774 -17.938 1.00 29.88 ? 406 VAL A O 1 ATOM 3060 C CB . VAL A 1 406 ? 20.023 -21.616 -19.389 1.00 27.79 ? 406 VAL A CB 1 ATOM 3061 C CG1 . VAL A 1 406 ? 21.153 -20.860 -19.967 1.00 28.95 ? 406 VAL A CG1 1 ATOM 3062 C CG2 . VAL A 1 406 ? 20.527 -22.987 -18.951 1.00 28.64 ? 406 VAL A CG2 1 ATOM 3063 N N . ARG A 1 407 ? 18.386 -18.766 -18.629 1.00 29.65 ? 407 ARG A N 1 ATOM 3064 C CA . ARG A 1 407 ? 18.267 -17.329 -18.659 1.00 30.62 ? 407 ARG A CA 1 ATOM 3065 C C . ARG A 1 407 ? 16.834 -16.886 -18.288 1.00 30.49 ? 407 ARG A C 1 ATOM 3066 O O . ARG A 1 407 ? 15.876 -17.171 -19.014 1.00 31.06 ? 407 ARG A O 1 ATOM 3067 C CB . ARG A 1 407 ? 18.657 -16.853 -20.057 1.00 31.25 ? 407 ARG A CB 1 ATOM 3068 C CG . ARG A 1 407 ? 18.585 -15.340 -20.247 1.00 32.96 ? 407 ARG A CG 1 ATOM 3069 C CD . ARG A 1 407 ? 19.158 -14.892 -21.588 1.00 32.03 ? 407 ARG A CD 1 ATOM 3070 N NE . ARG A 1 407 ? 18.874 -13.461 -21.739 1.00 34.81 ? 407 ARG A NE 1 ATOM 3071 C CZ . ARG A 1 407 ? 18.956 -12.763 -22.872 1.00 33.20 ? 407 ARG A CZ 1 ATOM 3072 N NH1 . ARG A 1 407 ? 19.349 -13.340 -24.005 1.00 33.72 ? 407 ARG A NH1 1 ATOM 3073 N NH2 . ARG A 1 407 ? 18.638 -11.476 -22.854 1.00 31.25 ? 407 ARG A NH2 1 ATOM 3074 N N . SER A 1 408 ? 16.687 -16.211 -17.155 1.00 30.43 ? 408 SER A N 1 ATOM 3075 C CA . SER A 1 408 ? 15.393 -15.782 -16.668 1.00 30.95 ? 408 SER A CA 1 ATOM 3076 C C . SER A 1 408 ? 15.008 -14.483 -17.311 1.00 31.73 ? 408 SER A C 1 ATOM 3077 O O . SER A 1 408 ? 15.871 -13.754 -17.782 1.00 32.48 ? 408 SER A O 1 ATOM 3078 C CB . SER A 1 408 ? 15.446 -15.572 -15.176 1.00 31.05 ? 408 SER A CB 1 ATOM 3079 O OG . SER A 1 408 ? 15.879 -16.738 -14.514 1.00 32.77 ? 408 SER A OG 1 ATOM 3080 N N . ALA A 1 409 ? 13.709 -14.195 -17.358 1.00 32.50 ? 409 ALA A N 1 ATOM 3081 C CA . ALA A 1 409 ? 13.215 -12.879 -17.800 1.00 33.15 ? 409 ALA A CA 1 ATOM 3082 C C . ALA A 1 409 ? 13.957 -11.823 -17.012 1.00 33.82 ? 409 ALA A C 1 ATOM 3083 O O . ALA A 1 409 ? 14.241 -12.020 -15.832 1.00 33.28 ? 409 ALA A O 1 ATOM 3084 C CB . ALA A 1 409 ? 11.702 -12.739 -17.551 1.00 32.30 ? 409 ALA A CB 1 ATOM 3085 N N . GLY A 1 410 ? 14.284 -10.720 -17.666 1.00 34.97 ? 410 GLY A N 1 ATOM 3086 C CA . GLY A 1 410 ? 14.805 -9.551 -16.965 1.00 37.16 ? 410 GLY A CA 1 ATOM 3087 C C . GLY A 1 410 ? 16.298 -9.571 -16.710 1.00 38.36 ? 410 GLY A C 1 ATOM 3088 O O . GLY A 1 410 ? 16.835 -8.637 -16.111 1.00 38.79 ? 410 GLY A O 1 ATOM 3089 N N . SER A 1 411 ? 16.964 -10.631 -17.165 1.00 39.20 ? 411 SER A N 1 ATOM 3090 C CA . SER A 1 411 ? 18.400 -10.787 -16.995 1.00 40.01 ? 411 SER A CA 1 ATOM 3091 C C . SER A 1 411 ? 19.018 -10.892 -18.378 1.00 40.67 ? 411 SER A C 1 ATOM 3092 O O . SER A 1 411 ? 18.299 -11.133 -19.345 1.00 40.43 ? 411 SER A O 1 ATOM 3093 C CB . SER A 1 411 ? 18.684 -12.045 -16.194 1.00 39.85 ? 411 SER A CB 1 ATOM 3094 O OG . SER A 1 411 ? 20.040 -12.095 -15.776 1.00 41.20 ? 411 SER A OG 1 ATOM 3095 N N . SER A 1 412 ? 20.330 -10.682 -18.495 1.00 41.33 ? 412 SER A N 1 ATOM 3096 C CA . SER A 1 412 ? 20.999 -10.965 -19.778 1.00 42.89 ? 412 SER A CA 1 ATOM 3097 C C . SER A 1 412 ? 22.024 -12.096 -19.664 1.00 42.51 ? 412 SER A C 1 ATOM 3098 O O . SER A 1 412 ? 22.411 -12.703 -20.654 1.00 42.65 ? 412 SER A O 1 ATOM 3099 C CB . SER A 1 412 ? 21.614 -9.705 -20.384 1.00 43.10 ? 412 SER A CB 1 ATOM 3100 O OG . SER A 1 412 ? 22.099 -8.886 -19.339 1.00 46.40 ? 412 SER A OG 1 ATOM 3101 N N . THR A 1 413 ? 22.415 -12.364 -18.426 1.00 42.37 ? 413 THR A N 1 ATOM 3102 C CA . THR A 1 413 ? 23.338 -13.401 -18.049 1.00 41.73 ? 413 THR A CA 1 ATOM 3103 C C . THR A 1 413 ? 22.706 -14.743 -18.339 1.00 40.87 ? 413 THR A C 1 ATOM 3104 O O . THR A 1 413 ? 21.505 -14.886 -18.156 1.00 41.39 ? 413 THR A O 1 ATOM 3105 C CB . THR A 1 413 ? 23.575 -13.278 -16.545 1.00 42.45 ? 413 THR A CB 1 ATOM 3106 O OG1 . THR A 1 413 ? 24.180 -12.003 -16.273 1.00 42.10 ? 413 THR A OG1 1 ATOM 3107 C CG2 . THR A 1 413 ? 24.461 -14.438 -15.975 1.00 44.21 ? 413 THR A CG2 1 ATOM 3108 N N . TYR A 1 414 ? 23.526 -15.684 -18.833 1.00 39.77 ? 414 TYR A N 1 ATOM 3109 C CA . TYR A 1 414 ? 23.256 -17.116 -18.961 1.00 37.94 ? 414 TYR A CA 1 ATOM 3110 C C . TYR A 1 414 ? 24.008 -17.801 -17.846 1.00 36.94 ? 414 TYR A C 1 ATOM 3111 O O . TYR A 1 414 ? 25.167 -17.514 -17.627 1.00 36.36 ? 414 TYR A O 1 ATOM 3112 C CB . TYR A 1 414 ? 23.799 -17.641 -20.302 1.00 38.94 ? 414 TYR A CB 1 ATOM 3113 C CG . TYR A 1 414 ? 22.956 -17.207 -21.488 1.00 39.77 ? 414 TYR A CG 1 ATOM 3114 C CD1 . TYR A 1 414 ? 23.127 -15.948 -22.058 1.00 39.25 ? 414 TYR A CD1 1 ATOM 3115 C CD2 . TYR A 1 414 ? 21.956 -18.052 -22.009 1.00 39.38 ? 414 TYR A CD2 1 ATOM 3116 C CE1 . TYR A 1 414 ? 22.340 -15.541 -23.115 1.00 41.31 ? 414 TYR A CE1 1 ATOM 3117 C CE2 . TYR A 1 414 ? 21.168 -17.661 -23.064 1.00 39.95 ? 414 TYR A CE2 1 ATOM 3118 C CZ . TYR A 1 414 ? 21.358 -16.396 -23.610 1.00 40.93 ? 414 TYR A CZ 1 ATOM 3119 O OH . TYR A 1 414 ? 20.559 -15.964 -24.638 1.00 41.05 ? 414 TYR A OH 1 ATOM 3120 N N . ASN A 1 415 ? 23.351 -18.704 -17.131 1.00 35.88 ? 415 ASN A N 1 ATOM 3121 C CA . ASN A 1 415 ? 23.973 -19.439 -16.051 1.00 34.65 ? 415 ASN A CA 1 ATOM 3122 C C . ASN A 1 415 ? 23.889 -20.960 -16.331 1.00 34.94 ? 415 ASN A C 1 ATOM 3123 O O . ASN A 1 415 ? 22.816 -21.546 -16.285 1.00 35.62 ? 415 ASN A O 1 ATOM 3124 C CB . ASN A 1 415 ? 23.271 -19.010 -14.771 1.00 34.34 ? 415 ASN A CB 1 ATOM 3125 C CG . ASN A 1 415 ? 23.782 -19.707 -13.514 1.00 34.10 ? 415 ASN A CG 1 ATOM 3126 O OD1 . ASN A 1 415 ? 24.618 -20.603 -13.552 1.00 35.27 ? 415 ASN A OD1 1 ATOM 3127 N ND2 . ASN A 1 415 ? 23.227 -19.315 -12.389 1.00 33.08 ? 415 ASN A ND2 1 ATOM 3128 N N . TYR A 1 416 ? 25.014 -21.588 -16.660 1.00 34.79 ? 416 TYR A N 1 ATOM 3129 C CA . TYR A 1 416 ? 25.061 -23.033 -16.937 1.00 34.74 ? 416 TYR A CA 1 ATOM 3130 C C . TYR A 1 416 ? 25.639 -23.699 -15.739 1.00 34.87 ? 416 TYR A C 1 ATOM 3131 O O . TYR A 1 416 ? 25.525 -24.916 -15.578 1.00 34.78 ? 416 TYR A O 1 ATOM 3132 C CB . TYR A 1 416 ? 25.945 -23.368 -18.158 1.00 34.56 ? 416 TYR A CB 1 ATOM 3133 C CG . TYR A 1 416 ? 25.596 -22.562 -19.375 1.00 33.92 ? 416 TYR A CG 1 ATOM 3134 C CD1 . TYR A 1 416 ? 24.616 -23.006 -20.249 1.00 34.88 ? 416 TYR A CD1 1 ATOM 3135 C CD2 . TYR A 1 416 ? 26.218 -21.338 -19.639 1.00 33.24 ? 416 TYR A CD2 1 ATOM 3136 C CE1 . TYR A 1 416 ? 24.257 -22.262 -21.365 1.00 36.78 ? 416 TYR A CE1 1 ATOM 3137 C CE2 . TYR A 1 416 ? 25.870 -20.582 -20.763 1.00 34.86 ? 416 TYR A CE2 1 ATOM 3138 C CZ . TYR A 1 416 ? 24.878 -21.053 -21.615 1.00 35.06 ? 416 TYR A CZ 1 ATOM 3139 O OH . TYR A 1 416 ? 24.493 -20.364 -22.731 1.00 34.59 ? 416 TYR A OH 1 ATOM 3140 N N . GLU A 1 417 ? 26.265 -22.888 -14.891 1.00 34.91 ? 417 GLU A N 1 ATOM 3141 C CA . GLU A 1 417 ? 26.938 -23.410 -13.704 1.00 36.00 ? 417 GLU A CA 1 ATOM 3142 C C . GLU A 1 417 ? 25.964 -23.974 -12.668 1.00 33.86 ? 417 GLU A C 1 ATOM 3143 O O . GLU A 1 417 ? 26.071 -25.136 -12.314 1.00 35.08 ? 417 GLU A O 1 ATOM 3144 C CB . GLU A 1 417 ? 27.923 -22.393 -13.094 1.00 35.52 ? 417 GLU A CB 1 ATOM 3145 C CG . GLU A 1 417 ? 28.736 -22.982 -11.923 1.00 39.11 ? 417 GLU A CG 1 ATOM 3146 C CD . GLU A 1 417 ? 30.037 -22.209 -11.582 1.00 40.99 ? 417 GLU A CD 1 ATOM 3147 O OE1 . GLU A 1 417 ? 30.505 -22.389 -10.415 1.00 45.63 ? 417 GLU A OE1 1 ATOM 3148 O OE2 . GLU A 1 417 ? 30.597 -21.467 -12.468 1.00 45.12 ? 417 GLU A OE2 1 ATOM 3149 N N . ASN A 1 418 ? 25.008 -23.179 -12.209 1.00 31.91 ? 418 ASN A N 1 ATOM 3150 C CA . ASN A 1 418 ? 24.092 -23.628 -11.167 1.00 30.26 ? 418 ASN A CA 1 ATOM 3151 C C . ASN A 1 418 ? 22.687 -22.974 -11.245 1.00 29.84 ? 418 ASN A C 1 ATOM 3152 O O . ASN A 1 418 ? 22.211 -22.409 -10.250 1.00 29.99 ? 418 ASN A O 1 ATOM 3153 C CB . ASN A 1 418 ? 24.721 -23.375 -9.812 1.00 29.24 ? 418 ASN A CB 1 ATOM 3154 C CG . ASN A 1 418 ? 25.097 -21.882 -9.591 1.00 30.16 ? 418 ASN A CG 1 ATOM 3155 O OD1 . ASN A 1 418 ? 24.745 -20.980 -10.369 1.00 30.36 ? 418 ASN A OD1 1 ATOM 3156 N ND2 . ASN A 1 418 ? 25.784 -21.634 -8.508 1.00 27.64 ? 418 ASN A ND2 1 ATOM 3157 N N . PRO A 1 419 ? 22.029 -23.025 -12.423 1.00 28.15 ? 419 PRO A N 1 ATOM 3158 C CA . PRO A 1 419 ? 20.736 -22.363 -12.576 1.00 27.35 ? 419 PRO A CA 1 ATOM 3159 C C . PRO A 1 419 ? 19.657 -22.909 -11.653 1.00 26.31 ? 419 PRO A C 1 ATOM 3160 O O . PRO A 1 419 ? 19.743 -24.056 -11.242 1.00 26.54 ? 419 PRO A O 1 ATOM 3161 C CB . PRO A 1 419 ? 20.362 -22.642 -14.046 1.00 27.05 ? 419 PRO A CB 1 ATOM 3162 C CG . PRO A 1 419 ? 21.205 -23.736 -14.463 1.00 27.96 ? 419 PRO A CG 1 ATOM 3163 C CD . PRO A 1 419 ? 22.465 -23.654 -13.670 1.00 27.92 ? 419 PRO A CD 1 ATOM 3164 N N . VAL A 1 420 ? 18.675 -22.081 -11.302 1.00 25.35 ? 420 VAL A N 1 ATOM 3165 C CA . VAL A 1 420 ? 17.402 -22.569 -10.745 1.00 24.72 ? 420 VAL A CA 1 ATOM 3166 C C . VAL A 1 420 ? 16.822 -23.628 -11.685 1.00 24.63 ? 420 VAL A C 1 ATOM 3167 O O . VAL A 1 420 ? 17.021 -23.549 -12.893 1.00 24.79 ? 420 VAL A O 1 ATOM 3168 C CB . VAL A 1 420 ? 16.362 -21.408 -10.518 1.00 24.06 ? 420 VAL A CB 1 ATOM 3169 C CG1 . VAL A 1 420 ? 15.849 -20.800 -11.817 1.00 22.82 ? 420 VAL A CG1 1 ATOM 3170 C CG2 . VAL A 1 420 ? 15.205 -21.880 -9.688 1.00 24.77 ? 420 VAL A CG2 1 ATOM 3171 N N . TYR A 1 421 ? 16.187 -24.655 -11.131 1.00 25.12 ? 421 TYR A N 1 ATOM 3172 C CA . TYR A 1 421 ? 15.354 -25.579 -11.925 1.00 25.55 ? 421 TYR A CA 1 ATOM 3173 C C . TYR A 1 421 ? 13.899 -25.417 -11.484 1.00 25.17 ? 421 TYR A C 1 ATOM 3174 O O . TYR A 1 421 ? 13.628 -25.310 -10.288 1.00 25.99 ? 421 TYR A O 1 ATOM 3175 C CB . TYR A 1 421 ? 15.745 -27.034 -11.673 1.00 25.60 ? 421 TYR A CB 1 ATOM 3176 C CG . TYR A 1 421 ? 16.892 -27.617 -12.471 1.00 26.80 ? 421 TYR A CG 1 ATOM 3177 C CD1 . TYR A 1 421 ? 18.218 -27.243 -12.219 1.00 27.05 ? 421 TYR A CD1 1 ATOM 3178 C CD2 . TYR A 1 421 ? 16.661 -28.613 -13.435 1.00 27.86 ? 421 TYR A CD2 1 ATOM 3179 C CE1 . TYR A 1 421 ? 19.289 -27.815 -12.956 1.00 27.27 ? 421 TYR A CE1 1 ATOM 3180 C CE2 . TYR A 1 421 ? 17.735 -29.196 -14.185 1.00 26.05 ? 421 TYR A CE2 1 ATOM 3181 C CZ . TYR A 1 421 ? 19.027 -28.786 -13.938 1.00 25.86 ? 421 TYR A CZ 1 ATOM 3182 O OH . TYR A 1 421 ? 20.063 -29.359 -14.640 1.00 27.28 ? 421 TYR A OH 1 ATOM 3183 N N . ARG A 1 422 ? 12.967 -25.453 -12.415 1.00 24.05 ? 422 ARG A N 1 ATOM 3184 C CA . ARG A 1 422 ? 11.559 -25.363 -12.069 1.00 23.89 ? 422 ARG A CA 1 ATOM 3185 C C . ARG A 1 422 ? 10.732 -25.934 -13.220 1.00 24.31 ? 422 ARG A C 1 ATOM 3186 O O . ARG A 1 422 ? 11.327 -26.441 -14.178 1.00 25.54 ? 422 ARG A O 1 ATOM 3187 C CB . ARG A 1 422 ? 11.177 -23.910 -11.775 1.00 23.70 ? 422 ARG A CB 1 ATOM 3188 C CG . ARG A 1 422 ? 11.308 -22.920 -12.957 1.00 21.91 ? 422 ARG A CG 1 ATOM 3189 C CD . ARG A 1 422 ? 11.133 -21.522 -12.445 1.00 21.22 ? 422 ARG A CD 1 ATOM 3190 N NE . ARG A 1 422 ? 9.997 -21.517 -11.535 1.00 24.61 ? 422 ARG A NE 1 ATOM 3191 C CZ . ARG A 1 422 ? 9.768 -20.620 -10.585 1.00 28.53 ? 422 ARG A CZ 1 ATOM 3192 N NH1 . ARG A 1 422 ? 8.686 -20.745 -9.816 1.00 28.18 ? 422 ARG A NH1 1 ATOM 3193 N NH2 . ARG A 1 422 ? 10.605 -19.597 -10.395 1.00 29.80 ? 422 ARG A NH2 1 ATOM 3194 N N . ASP A 1 423 ? 9.394 -25.858 -13.153 1.00 23.74 ? 423 ASP A N 1 ATOM 3195 C CA . ASP A 1 423 ? 8.551 -26.420 -14.233 1.00 23.19 ? 423 ASP A CA 1 ATOM 3196 C C . ASP A 1 423 ? 7.670 -25.374 -14.902 1.00 22.90 ? 423 ASP A C 1 ATOM 3197 O O . ASP A 1 423 ? 7.153 -25.615 -15.983 1.00 23.36 ? 423 ASP A O 1 ATOM 3198 C CB . ASP A 1 423 ? 7.745 -27.677 -13.803 1.00 22.79 ? 423 ASP A CB 1 ATOM 3199 C CG . ASP A 1 423 ? 6.736 -27.395 -12.685 1.00 22.40 ? 423 ASP A CG 1 ATOM 3200 O OD1 . ASP A 1 423 ? 5.938 -26.448 -12.799 1.00 24.40 ? 423 ASP A OD1 1 ATOM 3201 O OD2 . ASP A 1 423 ? 6.707 -28.137 -11.695 1.00 18.79 ? 423 ASP A OD2 1 ATOM 3202 N N . VAL A 1 424 ? 7.511 -24.217 -14.270 1.00 22.56 ? 424 VAL A N 1 ATOM 3203 C CA . VAL A 1 424 ? 6.797 -23.106 -14.889 1.00 22.45 ? 424 VAL A CA 1 ATOM 3204 C C . VAL A 1 424 ? 7.687 -21.864 -14.903 1.00 23.12 ? 424 VAL A C 1 ATOM 3205 O O . VAL A 1 424 ? 8.108 -21.407 -13.806 1.00 23.47 ? 424 VAL A O 1 ATOM 3206 C CB . VAL A 1 424 ? 5.554 -22.734 -14.087 1.00 21.90 ? 424 VAL A CB 1 ATOM 3207 C CG1 . VAL A 1 424 ? 4.911 -21.475 -14.692 1.00 21.68 ? 424 VAL A CG1 1 ATOM 3208 C CG2 . VAL A 1 424 ? 4.584 -23.862 -14.069 1.00 21.66 ? 424 VAL A CG2 1 ATOM 3209 N N . VAL A 1 425 ? 7.955 -21.297 -16.092 1.00 22.29 ? 425 VAL A N 1 ATOM 3210 C CA . VAL A 1 425 ? 8.812 -20.073 -16.170 1.00 21.96 ? 425 VAL A CA 1 ATOM 3211 C C . VAL A 1 425 ? 8.188 -18.863 -16.911 1.00 22.03 ? 425 VAL A C 1 ATOM 3212 O O . VAL A 1 425 ? 7.618 -19.035 -18.020 1.00 20.66 ? 425 VAL A O 1 ATOM 3213 C CB . VAL A 1 425 ? 10.228 -20.386 -16.776 1.00 21.97 ? 425 VAL A CB 1 ATOM 3214 C CG1 . VAL A 1 425 ? 10.131 -20.884 -18.238 1.00 22.30 ? 425 VAL A CG1 1 ATOM 3215 C CG2 . VAL A 1 425 ? 11.088 -19.190 -16.735 1.00 21.59 ? 425 VAL A CG2 1 ATOM 3216 N N . SER A 1 426 ? 8.293 -17.660 -16.318 1.00 21.56 ? 426 SER A N 1 ATOM 3217 C CA . SER A 1 426 ? 7.885 -16.453 -17.036 1.00 22.80 ? 426 SER A CA 1 ATOM 3218 C C . SER A 1 426 ? 8.755 -16.171 -18.272 1.00 23.70 ? 426 SER A C 1 ATOM 3219 O O . SER A 1 426 ? 9.983 -16.076 -18.168 1.00 24.24 ? 426 SER A O 1 ATOM 3220 C CB . SER A 1 426 ? 7.893 -15.222 -16.145 1.00 23.01 ? 426 SER A CB 1 ATOM 3221 O OG . SER A 1 426 ? 7.450 -14.077 -16.888 1.00 24.06 ? 426 SER A OG 1 ATOM 3222 N N . THR A 1 427 ? 8.147 -16.035 -19.438 1.00 24.02 ? 427 THR A N 1 ATOM 3223 C CA . THR A 1 427 ? 8.968 -15.817 -20.641 1.00 25.37 ? 427 THR A CA 1 ATOM 3224 C C . THR A 1 427 ? 9.170 -14.325 -20.839 1.00 26.78 ? 427 THR A C 1 ATOM 3225 O O . THR A 1 427 ? 9.640 -13.874 -21.882 1.00 26.90 ? 427 THR A O 1 ATOM 3226 C CB . THR A 1 427 ? 8.413 -16.501 -21.937 1.00 25.00 ? 427 THR A CB 1 ATOM 3227 O OG1 . THR A 1 427 ? 7.106 -15.983 -22.262 1.00 25.61 ? 427 THR A OG1 1 ATOM 3228 C CG2 . THR A 1 427 ? 8.334 -18.006 -21.758 1.00 22.41 ? 427 THR A CG2 1 ATOM 3229 N N . GLY A 1 428 ? 8.784 -13.567 -19.815 1.00 28.26 ? 428 GLY A N 1 ATOM 3230 C CA . GLY A 1 428 ? 9.142 -12.171 -19.695 1.00 29.71 ? 428 GLY A CA 1 ATOM 3231 C C . GLY A 1 428 ? 8.608 -11.339 -20.810 1.00 31.17 ? 428 GLY A C 1 ATOM 3232 O O . GLY A 1 428 ? 7.561 -11.648 -21.365 1.00 32.29 ? 428 GLY A O 1 ATOM 3233 N N . SER A 1 429 ? 9.319 -10.282 -21.158 1.00 32.21 ? 429 SER A N 1 ATOM 3234 C CA . SER A 1 429 ? 8.733 -9.284 -22.037 1.00 33.58 ? 429 SER A CA 1 ATOM 3235 C C . SER A 1 429 ? 9.769 -8.743 -23.069 1.00 34.14 ? 429 SER A C 1 ATOM 3236 O O . SER A 1 429 ? 10.931 -9.135 -23.016 1.00 34.46 ? 429 SER A O 1 ATOM 3237 C CB . SER A 1 429 ? 8.094 -8.204 -21.174 1.00 33.17 ? 429 SER A CB 1 ATOM 3238 O OG . SER A 1 429 ? 9.013 -7.159 -21.086 1.00 35.37 ? 429 SER A OG 1 ATOM 3239 N N . PRO A 1 430 ? 9.340 -7.921 -24.065 1.00 34.95 ? 430 PRO A N 1 ATOM 3240 C CA . PRO A 1 430 ? 10.255 -7.608 -25.193 1.00 34.83 ? 430 PRO A CA 1 ATOM 3241 C C . PRO A 1 430 ? 11.727 -7.420 -24.829 1.00 34.70 ? 430 PRO A C 1 ATOM 3242 O O . PRO A 1 430 ? 12.053 -6.605 -23.982 1.00 34.05 ? 430 PRO A O 1 ATOM 3243 C CB . PRO A 1 430 ? 9.667 -6.335 -25.759 1.00 34.69 ? 430 PRO A CB 1 ATOM 3244 C CG . PRO A 1 430 ? 8.230 -6.573 -25.592 1.00 34.40 ? 430 PRO A CG 1 ATOM 3245 C CD . PRO A 1 430 ? 8.023 -7.289 -24.283 1.00 34.12 ? 430 PRO A CD 1 ATOM 3246 N N . GLY A 1 431 ? 12.590 -8.217 -25.468 1.00 35.14 ? 431 GLY A N 1 ATOM 3247 C CA . GLY A 1 431 ? 14.041 -8.189 -25.251 1.00 34.92 ? 431 GLY A CA 1 ATOM 3248 C C . GLY A 1 431 ? 14.544 -9.271 -24.300 1.00 34.92 ? 431 GLY A C 1 ATOM 3249 O O . GLY A 1 431 ? 15.760 -9.451 -24.130 1.00 34.29 ? 431 GLY A O 1 ATOM 3250 N N . ASP A 1 432 ? 13.621 -9.975 -23.650 1.00 34.50 ? 432 ASP A N 1 ATOM 3251 C CA . ASP A 1 432 ? 14.006 -11.117 -22.845 1.00 34.45 ? 432 ASP A CA 1 ATOM 3252 C C . ASP A 1 432 ? 14.317 -12.250 -23.791 1.00 34.04 ? 432 ASP A C 1 ATOM 3253 O O . ASP A 1 432 ? 13.844 -12.257 -24.926 1.00 33.80 ? 432 ASP A O 1 ATOM 3254 C CB . ASP A 1 432 ? 12.862 -11.536 -21.950 1.00 34.53 ? 432 ASP A CB 1 ATOM 3255 C CG . ASP A 1 432 ? 12.744 -10.687 -20.741 1.00 36.11 ? 432 ASP A CG 1 ATOM 3256 O OD1 . ASP A 1 432 ? 13.784 -10.232 -20.243 1.00 40.69 ? 432 ASP A OD1 1 ATOM 3257 O OD2 . ASP A 1 432 ? 11.612 -10.486 -20.262 1.00 38.58 ? 432 ASP A OD2 1 ATOM 3258 N N . ASN A 1 433 ? 15.096 -13.222 -23.344 1.00 33.80 ? 433 ASN A N 1 ATOM 3259 C CA . ASN A 1 433 ? 15.206 -14.434 -24.140 1.00 33.74 ? 433 ASN A CA 1 ATOM 3260 C C . ASN A 1 433 ? 15.275 -15.660 -23.268 1.00 33.28 ? 433 ASN A C 1 ATOM 3261 O O . ASN A 1 433 ? 16.305 -16.360 -23.197 1.00 34.37 ? 433 ASN A O 1 ATOM 3262 C CB . ASN A 1 433 ? 16.384 -14.363 -25.113 1.00 33.83 ? 433 ASN A CB 1 ATOM 3263 C CG . ASN A 1 433 ? 16.280 -15.385 -26.245 1.00 34.61 ? 433 ASN A CG 1 ATOM 3264 O OD1 . ASN A 1 433 ? 17.186 -15.472 -27.087 1.00 34.31 ? 433 ASN A OD1 1 ATOM 3265 N ND2 . ASN A 1 433 ? 15.182 -16.155 -26.280 1.00 33.23 ? 433 ASN A ND2 1 ATOM 3266 N N . VAL A 1 434 ? 14.170 -15.931 -22.595 1.00 32.16 ? 434 VAL A N 1 ATOM 3267 C CA . VAL A 1 434 ? 14.151 -17.027 -21.641 1.00 30.70 ? 434 VAL A CA 1 ATOM 3268 C C . VAL A 1 434 ? 14.604 -18.294 -22.345 1.00 30.12 ? 434 VAL A C 1 ATOM 3269 O O . VAL A 1 434 ? 14.116 -18.603 -23.433 1.00 29.22 ? 434 VAL A O 1 ATOM 3270 C CB . VAL A 1 434 ? 12.785 -17.159 -20.980 1.00 30.37 ? 434 VAL A CB 1 ATOM 3271 C CG1 . VAL A 1 434 ? 12.629 -18.540 -20.302 1.00 30.31 ? 434 VAL A CG1 1 ATOM 3272 C CG2 . VAL A 1 434 ? 12.613 -15.992 -19.996 1.00 29.32 ? 434 VAL A CG2 1 ATOM 3273 N N . THR A 1 435 ? 15.573 -18.979 -21.735 1.00 29.22 ? 435 THR A N 1 ATOM 3274 C CA . THR A 1 435 ? 16.169 -20.169 -22.326 1.00 28.90 ? 435 THR A CA 1 ATOM 3275 C C . THR A 1 435 ? 16.258 -21.299 -21.309 1.00 28.76 ? 435 THR A C 1 ATOM 3276 O O . THR A 1 435 ? 16.725 -21.102 -20.171 1.00 28.92 ? 435 THR A O 1 ATOM 3277 C CB . THR A 1 435 ? 17.575 -19.854 -22.885 1.00 28.83 ? 435 THR A CB 1 ATOM 3278 O OG1 . THR A 1 435 ? 17.508 -18.644 -23.650 1.00 29.57 ? 435 THR A OG1 1 ATOM 3279 C CG2 . THR A 1 435 ? 18.063 -20.964 -23.757 1.00 26.88 ? 435 THR A CG2 1 ATOM 3280 N N . ILE A 1 436 ? 15.823 -22.486 -21.718 1.00 28.45 ? 436 ILE A N 1 ATOM 3281 C CA . ILE A 1 436 ? 15.682 -23.592 -20.772 1.00 28.43 ? 436 ILE A CA 1 ATOM 3282 C C . ILE A 1 436 ? 16.320 -24.843 -21.302 1.00 28.72 ? 436 ILE A C 1 ATOM 3283 O O . ILE A 1 436 ? 16.461 -25.031 -22.513 1.00 29.29 ? 436 ILE A O 1 ATOM 3284 C CB . ILE A 1 436 ? 14.200 -23.907 -20.433 1.00 28.48 ? 436 ILE A CB 1 ATOM 3285 C CG1 . ILE A 1 436 ? 13.482 -24.486 -21.656 1.00 27.53 ? 436 ILE A CG1 1 ATOM 3286 C CG2 . ILE A 1 436 ? 13.498 -22.679 -19.822 1.00 26.76 ? 436 ILE A CG2 1 ATOM 3287 C CD1 . ILE A 1 436 ? 12.076 -25.028 -21.398 1.00 28.58 ? 436 ILE A CD1 1 ATOM 3288 N N . ARG A 1 437 ? 16.701 -25.710 -20.386 1.00 28.59 ? 437 ARG A N 1 ATOM 3289 C CA . ARG A 1 437 ? 17.357 -26.961 -20.749 1.00 28.42 ? 437 ARG A CA 1 ATOM 3290 C C . ARG A 1 437 ? 16.826 -28.108 -19.923 1.00 28.16 ? 437 ARG A C 1 ATOM 3291 O O . ARG A 1 437 ? 16.511 -27.923 -18.721 1.00 26.35 ? 437 ARG A O 1 ATOM 3292 C CB . ARG A 1 437 ? 18.867 -26.851 -20.528 1.00 28.08 ? 437 ARG A CB 1 ATOM 3293 C CG . ARG A 1 437 ? 19.560 -25.946 -21.515 1.00 28.74 ? 437 ARG A CG 1 ATOM 3294 C CD . ARG A 1 437 ? 21.047 -26.029 -21.341 1.00 28.87 ? 437 ARG A CD 1 ATOM 3295 N NE . ARG A 1 437 ? 21.767 -25.217 -22.311 1.00 30.06 ? 437 ARG A NE 1 ATOM 3296 C CZ . ARG A 1 437 ? 23.067 -25.339 -22.560 1.00 29.16 ? 437 ARG A CZ 1 ATOM 3297 N NH1 . ARG A 1 437 ? 23.788 -26.227 -21.894 1.00 31.49 ? 437 ARG A NH1 1 ATOM 3298 N NH2 . ARG A 1 437 ? 23.642 -24.562 -23.447 1.00 25.05 ? 437 ARG A NH2 1 ATOM 3299 N N . PHE A 1 438 ? 16.772 -29.286 -20.561 1.00 28.16 ? 438 PHE A N 1 ATOM 3300 C CA . PHE A 1 438 ? 16.440 -30.552 -19.860 1.00 29.17 ? 438 PHE A CA 1 ATOM 3301 C C . PHE A 1 438 ? 16.993 -31.756 -20.604 1.00 30.03 ? 438 PHE A C 1 ATOM 3302 O O . PHE A 1 438 ? 17.396 -31.619 -21.735 1.00 30.49 ? 438 PHE A O 1 ATOM 3303 C CB . PHE A 1 438 ? 14.915 -30.705 -19.679 1.00 27.96 ? 438 PHE A CB 1 ATOM 3304 C CG . PHE A 1 438 ? 14.141 -30.626 -20.969 1.00 26.15 ? 438 PHE A CG 1 ATOM 3305 C CD1 . PHE A 1 438 ? 13.900 -29.396 -21.575 1.00 26.06 ? 438 PHE A CD1 1 ATOM 3306 C CD2 . PHE A 1 438 ? 13.656 -31.775 -21.565 1.00 23.26 ? 438 PHE A CD2 1 ATOM 3307 C CE1 . PHE A 1 438 ? 13.195 -29.312 -22.757 1.00 25.20 ? 438 PHE A CE1 1 ATOM 3308 C CE2 . PHE A 1 438 ? 12.951 -31.720 -22.725 1.00 23.46 ? 438 PHE A CE2 1 ATOM 3309 C CZ . PHE A 1 438 ? 12.721 -30.486 -23.337 1.00 26.70 ? 438 PHE A CZ 1 ATOM 3310 N N . ARG A 1 439 ? 16.975 -32.931 -19.977 1.00 32.01 ? 439 ARG A N 1 ATOM 3311 C CA . ARG A 1 439 ? 17.464 -34.183 -20.589 1.00 34.21 ? 439 ARG A CA 1 ATOM 3312 C C . ARG A 1 439 ? 16.282 -35.089 -20.952 1.00 34.57 ? 439 ARG A C 1 ATOM 3313 O O . ARG A 1 439 ? 15.280 -35.112 -20.264 1.00 34.22 ? 439 ARG A O 1 ATOM 3314 C CB . ARG A 1 439 ? 18.483 -34.883 -19.645 1.00 34.50 ? 439 ARG A CB 1 ATOM 3315 C CG . ARG A 1 439 ? 18.811 -36.354 -19.928 1.00 35.62 ? 439 ARG A CG 1 ATOM 3316 C CD . ARG A 1 439 ? 20.227 -36.751 -19.463 1.00 36.07 ? 439 ARG A CD 1 ATOM 3317 N NE . ARG A 1 439 ? 21.217 -36.344 -20.457 1.00 41.08 ? 439 ARG A NE 1 ATOM 3318 C CZ . ARG A 1 439 ? 21.844 -37.163 -21.303 1.00 43.68 ? 439 ARG A CZ 1 ATOM 3319 N NH1 . ARG A 1 439 ? 21.609 -38.482 -21.304 1.00 44.30 ? 439 ARG A NH1 1 ATOM 3320 N NH2 . ARG A 1 439 ? 22.718 -36.651 -22.163 1.00 44.04 ? 439 ARG A NH2 1 ATOM 3321 N N . THR A 1 440 ? 16.387 -35.831 -22.040 1.00 35.83 ? 440 THR A N 1 ATOM 3322 C CA . THR A 1 440 ? 15.250 -36.634 -22.463 1.00 37.07 ? 440 THR A CA 1 ATOM 3323 C C . THR A 1 440 ? 15.142 -38.041 -21.878 1.00 37.77 ? 440 THR A C 1 ATOM 3324 O O . THR A 1 440 ? 15.002 -39.026 -22.621 1.00 38.91 ? 440 THR A O 1 ATOM 3325 C CB . THR A 1 440 ? 15.167 -36.695 -23.938 1.00 37.08 ? 440 THR A CB 1 ATOM 3326 O OG1 . THR A 1 440 ? 16.465 -37.035 -24.432 1.00 37.15 ? 440 THR A OG1 1 ATOM 3327 C CG2 . THR A 1 440 ? 14.733 -35.324 -24.467 1.00 37.46 ? 440 THR A CG2 1 ATOM 3328 N N . ASP A 1 441 ? 15.184 -38.077 -20.543 1.00 37.81 ? 441 ASP A N 1 ATOM 3329 C CA . ASP A 1 441 ? 14.837 -39.168 -19.638 1.00 37.69 ? 441 ASP A CA 1 ATOM 3330 C C . ASP A 1 441 ? 13.561 -39.944 -19.835 1.00 37.03 ? 441 ASP A C 1 ATOM 3331 O O . ASP A 1 441 ? 13.458 -41.097 -19.396 1.00 38.20 ? 441 ASP A O 1 ATOM 3332 C CB . ASP A 1 441 ? 14.658 -38.305 -18.401 1.00 38.91 ? 441 ASP A CB 1 ATOM 3333 C CG . ASP A 1 441 ? 15.889 -38.166 -17.619 1.00 44.01 ? 441 ASP A CG 1 ATOM 3334 O OD1 . ASP A 1 441 ? 16.762 -39.049 -17.746 1.00 51.56 ? 441 ASP A OD1 1 ATOM 3335 O OD2 . ASP A 1 441 ? 15.992 -37.180 -16.862 1.00 49.83 ? 441 ASP A OD2 1 ATOM 3336 N N . ASN A 1 442 ? 12.540 -39.286 -20.368 1.00 35.10 ? 442 ASN A N 1 ATOM 3337 C CA . ASN A 1 442 ? 11.169 -39.630 -20.002 1.00 32.78 ? 442 ASN A CA 1 ATOM 3338 C C . ASN A 1 442 ? 10.259 -39.752 -21.241 1.00 32.13 ? 442 ASN A C 1 ATOM 3339 O O . ASN A 1 442 ? 9.656 -38.759 -21.672 1.00 32.05 ? 442 ASN A O 1 ATOM 3340 C CB . ASN A 1 442 ? 10.659 -38.563 -19.003 1.00 32.04 ? 442 ASN A CB 1 ATOM 3341 C CG . ASN A 1 442 ? 9.411 -38.971 -18.292 1.00 30.10 ? 442 ASN A CG 1 ATOM 3342 O OD1 . ASN A 1 442 ? 9.067 -40.145 -18.280 1.00 30.04 ? 442 ASN A OD1 1 ATOM 3343 N ND2 . ASN A 1 442 ? 8.720 -38.008 -17.677 1.00 28.21 ? 442 ASN A ND2 1 ATOM 3344 N N . PRO A 1 443 ? 10.174 -40.965 -21.827 1.00 31.04 ? 443 PRO A N 1 ATOM 3345 C CA . PRO A 1 443 ? 9.450 -41.217 -23.073 1.00 30.17 ? 443 PRO A CA 1 ATOM 3346 C C . PRO A 1 443 ? 7.960 -40.932 -22.968 1.00 29.75 ? 443 PRO A C 1 ATOM 3347 O O . PRO A 1 443 ? 7.308 -41.330 -21.958 1.00 29.02 ? 443 PRO A O 1 ATOM 3348 C CB . PRO A 1 443 ? 9.666 -42.701 -23.310 1.00 30.13 ? 443 PRO A CB 1 ATOM 3349 C CG . PRO A 1 443 ? 10.864 -43.022 -22.552 1.00 31.43 ? 443 PRO A CG 1 ATOM 3350 C CD . PRO A 1 443 ? 10.817 -42.184 -21.332 1.00 30.91 ? 443 PRO A CD 1 ATOM 3351 N N . GLY A 1 444 ? 7.452 -40.244 -24.000 1.00 28.15 ? 444 GLY A N 1 ATOM 3352 C CA . GLY A 1 444 ? 6.043 -39.911 -24.116 1.00 27.63 ? 444 GLY A CA 1 ATOM 3353 C C . GLY A 1 444 ? 5.766 -38.521 -24.669 1.00 27.73 ? 444 GLY A C 1 ATOM 3354 O O . GLY A 1 444 ? 6.668 -37.669 -24.746 1.00 28.26 ? 444 GLY A O 1 ATOM 3355 N N . PRO A 1 445 ? 4.511 -38.260 -25.054 1.00 27.20 ? 445 PRO A N 1 ATOM 3356 C CA . PRO A 1 445 ? 4.222 -36.907 -25.532 1.00 27.31 ? 445 PRO A CA 1 ATOM 3357 C C . PRO A 1 445 ? 3.970 -35.922 -24.371 1.00 27.57 ? 445 PRO A C 1 ATOM 3358 O O . PRO A 1 445 ? 3.127 -36.183 -23.501 1.00 28.54 ? 445 PRO A O 1 ATOM 3359 C CB . PRO A 1 445 ? 2.979 -37.104 -26.392 1.00 26.97 ? 445 PRO A CB 1 ATOM 3360 C CG . PRO A 1 445 ? 2.356 -38.379 -25.897 1.00 26.54 ? 445 PRO A CG 1 ATOM 3361 C CD . PRO A 1 445 ? 3.332 -39.133 -25.063 1.00 26.56 ? 445 PRO A CD 1 ATOM 3362 N N . TRP A 1 446 ? 4.720 -34.826 -24.328 1.00 27.04 ? 446 TRP A N 1 ATOM 3363 C CA . TRP A 1 446 ? 4.599 -33.899 -23.224 1.00 26.94 ? 446 TRP A CA 1 ATOM 3364 C C . TRP A 1 446 ? 4.219 -32.529 -23.746 1.00 27.29 ? 446 TRP A C 1 ATOM 3365 O O . TRP A 1 446 ? 4.913 -31.976 -24.630 1.00 28.45 ? 446 TRP A O 1 ATOM 3366 C CB . TRP A 1 446 ? 5.893 -33.832 -22.411 1.00 26.77 ? 446 TRP A CB 1 ATOM 3367 C CG . TRP A 1 446 ? 6.326 -35.187 -21.852 1.00 27.71 ? 446 TRP A CG 1 ATOM 3368 C CD1 . TRP A 1 446 ? 7.384 -35.943 -22.281 1.00 28.21 ? 446 TRP A CD1 1 ATOM 3369 C CD2 . TRP A 1 446 ? 5.695 -35.949 -20.803 1.00 27.03 ? 446 TRP A CD2 1 ATOM 3370 N NE1 . TRP A 1 446 ? 7.448 -37.122 -21.567 1.00 29.04 ? 446 TRP A NE1 1 ATOM 3371 C CE2 . TRP A 1 446 ? 6.433 -37.145 -20.648 1.00 28.74 ? 446 TRP A CE2 1 ATOM 3372 C CE3 . TRP A 1 446 ? 4.583 -35.737 -19.982 1.00 25.49 ? 446 TRP A CE3 1 ATOM 3373 C CZ2 . TRP A 1 446 ? 6.105 -38.112 -19.689 1.00 28.53 ? 446 TRP A CZ2 1 ATOM 3374 C CZ3 . TRP A 1 446 ? 4.259 -36.688 -19.039 1.00 26.07 ? 446 TRP A CZ3 1 ATOM 3375 C CH2 . TRP A 1 446 ? 5.013 -37.859 -18.895 1.00 27.94 ? 446 TRP A CH2 1 ATOM 3376 N N . PHE A 1 447 ? 3.125 -31.991 -23.204 1.00 25.92 ? 447 PHE A N 1 ATOM 3377 C CA . PHE A 1 447 ? 2.616 -30.695 -23.577 1.00 25.41 ? 447 PHE A CA 1 ATOM 3378 C C . PHE A 1 447 ? 3.640 -29.665 -23.140 1.00 25.49 ? 447 PHE A C 1 ATOM 3379 O O . PHE A 1 447 ? 4.227 -29.830 -22.064 1.00 25.55 ? 447 PHE A O 1 ATOM 3380 C CB . PHE A 1 447 ? 1.321 -30.394 -22.792 1.00 25.53 ? 447 PHE A CB 1 ATOM 3381 C CG . PHE A 1 447 ? 0.186 -29.897 -23.641 1.00 24.10 ? 447 PHE A CG 1 ATOM 3382 C CD1 . PHE A 1 447 ? 0.352 -29.664 -24.991 1.00 24.75 ? 447 PHE A CD1 1 ATOM 3383 C CD2 . PHE A 1 447 ? -1.061 -29.711 -23.091 1.00 23.89 ? 447 PHE A CD2 1 ATOM 3384 C CE1 . PHE A 1 447 ? -0.695 -29.229 -25.765 1.00 24.56 ? 447 PHE A CE1 1 ATOM 3385 C CE2 . PHE A 1 447 ? -2.104 -29.282 -23.855 1.00 23.98 ? 447 PHE A CE2 1 ATOM 3386 C CZ . PHE A 1 447 ? -1.921 -29.039 -25.199 1.00 24.57 ? 447 PHE A CZ 1 ATOM 3387 N N . LEU A 1 448 ? 3.821 -28.606 -23.932 1.00 24.95 ? 448 LEU A N 1 ATOM 3388 C CA . LEU A 1 448 ? 4.604 -27.431 -23.515 1.00 25.24 ? 448 LEU A CA 1 ATOM 3389 C C . LEU A 1 448 ? 3.834 -26.205 -23.951 1.00 26.02 ? 448 LEU A C 1 ATOM 3390 O O . LEU A 1 448 ? 3.768 -25.894 -25.138 1.00 26.95 ? 448 LEU A O 1 ATOM 3391 C CB . LEU A 1 448 ? 6.024 -27.421 -24.133 1.00 25.05 ? 448 LEU A CB 1 ATOM 3392 C CG . LEU A 1 448 ? 6.820 -26.104 -24.118 1.00 25.07 ? 448 LEU A CG 1 ATOM 3393 C CD1 . LEU A 1 448 ? 7.310 -25.764 -22.711 1.00 24.03 ? 448 LEU A CD1 1 ATOM 3394 C CD2 . LEU A 1 448 ? 7.973 -26.108 -25.111 1.00 24.06 ? 448 LEU A CD2 1 ATOM 3395 N N . HIS A 1 449 ? 3.244 -25.511 -22.997 1.00 26.29 ? 449 HIS A N 1 ATOM 3396 C CA . HIS A 1 449 ? 2.243 -24.518 -23.308 1.00 26.08 ? 449 HIS A CA 1 ATOM 3397 C C . HIS A 1 449 ? 2.320 -23.381 -22.323 1.00 25.60 ? 449 HIS A C 1 ATOM 3398 O O . HIS A 1 449 ? 2.936 -23.487 -21.273 1.00 24.11 ? 449 HIS A O 1 ATOM 3399 C CB . HIS A 1 449 ? 0.843 -25.139 -23.213 1.00 26.20 ? 449 HIS A CB 1 ATOM 3400 C CG . HIS A 1 449 ? 0.460 -25.548 -21.824 1.00 28.10 ? 449 HIS A CG 1 ATOM 3401 N ND1 . HIS A 1 449 ? -0.145 -24.684 -20.929 1.00 28.79 ? 449 HIS A ND1 1 ATOM 3402 C CD2 . HIS A 1 449 ? 0.612 -26.731 -21.170 1.00 29.60 ? 449 HIS A CD2 1 ATOM 3403 C CE1 . HIS A 1 449 ? -0.338 -25.316 -19.782 1.00 30.67 ? 449 HIS A CE1 1 ATOM 3404 N NE2 . HIS A 1 449 ? 0.087 -26.568 -19.913 1.00 31.28 ? 449 HIS A NE2 1 ATOM 3405 N N . CYS A 1 450 ? 1.662 -22.293 -22.702 1.00 26.21 ? 450 CYS A N 1 ATOM 3406 C CA . CYS A 1 450 ? 1.494 -21.122 -21.875 1.00 26.09 ? 450 CYS A CA 1 ATOM 3407 C C . CYS A 1 450 ? 0.444 -21.429 -20.832 1.00 25.69 ? 450 CYS A C 1 ATOM 3408 O O . CYS A 1 450 ? -0.611 -21.937 -21.163 1.00 25.42 ? 450 CYS A O 1 ATOM 3409 C CB . CYS A 1 450 ? 1.010 -19.962 -22.735 1.00 25.17 ? 450 CYS A CB 1 ATOM 3410 S SG . CYS A 1 450 ? 0.598 -18.549 -21.744 1.00 28.07 ? 450 CYS A SG 1 ATOM 3411 N N . HIS A 1 451 ? 0.717 -21.103 -19.581 1.00 25.46 ? 451 HIS A N 1 ATOM 3412 C CA . HIS A 1 451 ? -0.194 -21.506 -18.532 1.00 25.86 ? 451 HIS A CA 1 ATOM 3413 C C . HIS A 1 451 ? -1.283 -20.506 -18.210 1.00 26.83 ? 451 HIS A C 1 ATOM 3414 O O . HIS A 1 451 ? -1.964 -20.601 -17.183 1.00 27.03 ? 451 HIS A O 1 ATOM 3415 C CB . HIS A 1 451 ? 0.546 -21.864 -17.276 1.00 25.14 ? 451 HIS A CB 1 ATOM 3416 C CG . HIS A 1 451 ? -0.139 -22.935 -16.499 1.00 25.22 ? 451 HIS A CG 1 ATOM 3417 N ND1 . HIS A 1 451 ? -1.400 -22.773 -15.965 1.00 25.95 ? 451 HIS A ND1 1 ATOM 3418 C CD2 . HIS A 1 451 ? 0.245 -24.193 -16.192 1.00 24.99 ? 451 HIS A CD2 1 ATOM 3419 C CE1 . HIS A 1 451 ? -1.754 -23.879 -15.342 1.00 26.53 ? 451 HIS A CE1 1 ATOM 3420 N NE2 . HIS A 1 451 ? -0.767 -24.753 -15.456 1.00 28.50 ? 451 HIS A NE2 1 ATOM 3421 N N . ILE A 1 452 ? -1.418 -19.522 -19.089 1.00 28.09 ? 452 ILE A N 1 ATOM 3422 C CA . ILE A 1 452 ? -2.570 -18.628 -19.093 1.00 28.44 ? 452 ILE A CA 1 ATOM 3423 C C . ILE A 1 452 ? -3.624 -19.388 -19.867 1.00 28.68 ? 452 ILE A C 1 ATOM 3424 O O . ILE A 1 452 ? -3.465 -19.642 -21.052 1.00 28.32 ? 452 ILE A O 1 ATOM 3425 C CB . ILE A 1 452 ? -2.222 -17.255 -19.731 1.00 28.18 ? 452 ILE A CB 1 ATOM 3426 C CG1 . ILE A 1 452 ? -1.164 -16.569 -18.861 1.00 26.67 ? 452 ILE A CG1 1 ATOM 3427 C CG2 . ILE A 1 452 ? -3.485 -16.408 -19.859 1.00 28.22 ? 452 ILE A CG2 1 ATOM 3428 C CD1 . ILE A 1 452 ? -0.819 -15.192 -19.256 1.00 27.75 ? 452 ILE A CD1 1 ATOM 3429 N N . ASP A 1 453 ? -4.682 -19.795 -19.183 1.00 29.36 ? 453 ASP A N 1 ATOM 3430 C CA . ASP A 1 453 ? -5.525 -20.850 -19.722 1.00 30.03 ? 453 ASP A CA 1 ATOM 3431 C C . ASP A 1 453 ? -6.210 -20.412 -20.995 1.00 31.09 ? 453 ASP A C 1 ATOM 3432 O O . ASP A 1 453 ? -6.332 -21.204 -21.956 1.00 32.29 ? 453 ASP A O 1 ATOM 3433 C CB . ASP A 1 453 ? -6.511 -21.362 -18.672 1.00 29.77 ? 453 ASP A CB 1 ATOM 3434 C CG . ASP A 1 453 ? -6.673 -22.881 -18.713 1.00 29.16 ? 453 ASP A CG 1 ATOM 3435 O OD1 . ASP A 1 453 ? -5.678 -23.580 -18.968 1.00 28.90 ? 453 ASP A OD1 1 ATOM 3436 O OD2 . ASP A 1 453 ? -7.787 -23.382 -18.455 1.00 27.73 ? 453 ASP A OD2 1 ATOM 3437 N N . PHE A 1 454 ? -6.613 -19.142 -21.023 1.00 31.33 ? 454 PHE A N 1 ATOM 3438 C CA . PHE A 1 454 ? -7.261 -18.560 -22.197 1.00 31.49 ? 454 PHE A CA 1 ATOM 3439 C C . PHE A 1 454 ? -6.342 -18.531 -23.423 1.00 31.82 ? 454 PHE A C 1 ATOM 3440 O O . PHE A 1 454 ? -6.815 -18.641 -24.568 1.00 32.51 ? 454 PHE A O 1 ATOM 3441 C CB . PHE A 1 454 ? -7.802 -17.185 -21.846 1.00 31.78 ? 454 PHE A CB 1 ATOM 3442 C CG . PHE A 1 454 ? -8.498 -17.147 -20.507 1.00 32.80 ? 454 PHE A CG 1 ATOM 3443 C CD1 . PHE A 1 454 ? -9.684 -17.866 -20.299 1.00 33.78 ? 454 PHE A CD1 1 ATOM 3444 C CD2 . PHE A 1 454 ? -7.948 -16.427 -19.440 1.00 32.76 ? 454 PHE A CD2 1 ATOM 3445 C CE1 . PHE A 1 454 ? -10.319 -17.857 -19.049 1.00 33.37 ? 454 PHE A CE1 1 ATOM 3446 C CE2 . PHE A 1 454 ? -8.566 -16.399 -18.197 1.00 32.74 ? 454 PHE A CE2 1 ATOM 3447 C CZ . PHE A 1 454 ? -9.765 -17.120 -18.000 1.00 33.45 ? 454 PHE A CZ 1 ATOM 3448 N N . HIS A 1 455 ? -5.028 -18.419 -23.182 1.00 31.70 ? 455 HIS A N 1 ATOM 3449 C CA . HIS A 1 455 ? -4.012 -18.499 -24.243 1.00 30.80 ? 455 HIS A CA 1 ATOM 3450 C C . HIS A 1 455 ? -3.853 -19.925 -24.737 1.00 31.32 ? 455 HIS A C 1 ATOM 3451 O O . HIS A 1 455 ? -3.750 -20.170 -25.955 1.00 32.16 ? 455 HIS A O 1 ATOM 3452 C CB . HIS A 1 455 ? -2.688 -17.893 -23.785 1.00 30.01 ? 455 HIS A CB 1 ATOM 3453 C CG . HIS A 1 455 ? -2.796 -16.441 -23.414 1.00 29.88 ? 455 HIS A CG 1 ATOM 3454 N ND1 . HIS A 1 455 ? -1.830 -15.779 -22.686 1.00 30.91 ? 455 HIS A ND1 1 ATOM 3455 C CD2 . HIS A 1 455 ? -3.767 -15.528 -23.654 1.00 28.11 ? 455 HIS A CD2 1 ATOM 3456 C CE1 . HIS A 1 455 ? -2.191 -14.519 -22.509 1.00 28.77 ? 455 HIS A CE1 1 ATOM 3457 N NE2 . HIS A 1 455 ? -3.365 -14.341 -23.082 1.00 29.20 ? 455 HIS A NE2 1 ATOM 3458 N N . LEU A 1 456 ? -3.883 -20.876 -23.805 1.00 31.12 ? 456 LEU A N 1 ATOM 3459 C CA . LEU A 1 456 ? -3.877 -22.266 -24.180 1.00 30.47 ? 456 LEU A CA 1 ATOM 3460 C C . LEU A 1 456 ? -5.091 -22.566 -25.044 1.00 30.70 ? 456 LEU A C 1 ATOM 3461 O O . LEU A 1 456 ? -4.936 -23.228 -26.079 1.00 30.21 ? 456 LEU A O 1 ATOM 3462 C CB . LEU A 1 456 ? -3.863 -23.183 -22.959 1.00 30.43 ? 456 LEU A CB 1 ATOM 3463 C CG . LEU A 1 456 ? -4.056 -24.709 -23.131 1.00 28.79 ? 456 LEU A CG 1 ATOM 3464 C CD1 . LEU A 1 456 ? -3.052 -25.378 -24.105 1.00 25.59 ? 456 LEU A CD1 1 ATOM 3465 C CD2 . LEU A 1 456 ? -4.022 -25.397 -21.744 1.00 29.67 ? 456 LEU A CD2 1 ATOM 3466 N N . GLU A 1 457 ? -6.275 -22.078 -24.641 1.00 30.82 ? 457 GLU A N 1 ATOM 3467 C CA . GLU A 1 457 ? -7.507 -22.382 -25.390 1.00 31.08 ? 457 GLU A CA 1 ATOM 3468 C C . GLU A 1 457 ? -7.396 -21.883 -26.817 1.00 31.23 ? 457 GLU A C 1 ATOM 3469 O O . GLU A 1 457 ? -7.819 -22.570 -27.743 1.00 31.73 ? 457 GLU A O 1 ATOM 3470 C CB . GLU A 1 457 ? -8.760 -21.803 -24.732 1.00 31.66 ? 457 GLU A CB 1 ATOM 3471 C CG . GLU A 1 457 ? -10.111 -22.140 -25.432 1.00 32.81 ? 457 GLU A CG 1 ATOM 3472 C CD . GLU A 1 457 ? -10.529 -23.644 -25.370 1.00 37.96 ? 457 GLU A CD 1 ATOM 3473 O OE1 . GLU A 1 457 ? -11.635 -24.000 -25.881 1.00 37.37 ? 457 GLU A OE1 1 ATOM 3474 O OE2 . GLU A 1 457 ? -9.759 -24.475 -24.835 1.00 39.48 ? 457 GLU A OE2 1 ATOM 3475 N N . ALA A 1 458 ? -6.793 -20.704 -26.984 1.00 30.65 ? 458 ALA A N 1 ATOM 3476 C CA . ALA A 1 458 ? -6.507 -20.141 -28.293 1.00 29.65 ? 458 ALA A CA 1 ATOM 3477 C C . ALA A 1 458 ? -5.207 -20.664 -28.963 1.00 29.57 ? 458 ALA A C 1 ATOM 3478 O O . ALA A 1 458 ? -4.658 -20.024 -29.851 1.00 29.33 ? 458 ALA A O 1 ATOM 3479 C CB . ALA A 1 458 ? -6.519 -18.621 -28.189 1.00 30.09 ? 458 ALA A CB 1 ATOM 3480 N N . GLY A 1 459 ? -4.740 -21.847 -28.568 1.00 29.80 ? 459 GLY A N 1 ATOM 3481 C CA . GLY A 1 459 ? -3.720 -22.597 -29.355 1.00 29.42 ? 459 GLY A CA 1 ATOM 3482 C C . GLY A 1 459 ? -2.219 -22.444 -29.032 1.00 28.89 ? 459 GLY A C 1 ATOM 3483 O O . GLY A 1 459 ? -1.388 -22.898 -29.814 1.00 28.73 ? 459 GLY A O 1 ATOM 3484 N N . PHE A 1 460 ? -1.896 -21.851 -27.873 1.00 28.28 ? 460 PHE A N 1 ATOM 3485 C CA . PHE A 1 460 ? -0.529 -21.457 -27.461 1.00 27.70 ? 460 PHE A CA 1 ATOM 3486 C C . PHE A 1 460 ? 0.179 -22.633 -26.787 1.00 27.07 ? 460 PHE A C 1 ATOM 3487 O O . PHE A 1 460 ? 0.387 -22.668 -25.580 1.00 26.72 ? 460 PHE A O 1 ATOM 3488 C CB . PHE A 1 460 ? -0.589 -20.188 -26.562 1.00 26.89 ? 460 PHE A CB 1 ATOM 3489 C CG . PHE A 1 460 ? 0.635 -19.287 -26.647 1.00 26.67 ? 460 PHE A CG 1 ATOM 3490 C CD1 . PHE A 1 460 ? 1.557 -19.392 -27.707 1.00 27.25 ? 460 PHE A CD1 1 ATOM 3491 C CD2 . PHE A 1 460 ? 0.846 -18.294 -25.680 1.00 24.92 ? 460 PHE A CD2 1 ATOM 3492 C CE1 . PHE A 1 460 ? 2.678 -18.544 -27.787 1.00 25.73 ? 460 PHE A CE1 1 ATOM 3493 C CE2 . PHE A 1 460 ? 1.944 -17.452 -25.737 1.00 24.96 ? 460 PHE A CE2 1 ATOM 3494 C CZ . PHE A 1 460 ? 2.879 -17.572 -26.804 1.00 26.72 ? 460 PHE A CZ 1 ATOM 3495 N N . ALA A 1 461 ? 0.532 -23.610 -27.601 1.00 27.16 ? 461 ALA A N 1 ATOM 3496 C CA . ALA A 1 461 ? 1.000 -24.911 -27.114 1.00 27.57 ? 461 ALA A CA 1 ATOM 3497 C C . ALA A 1 461 ? 1.694 -25.650 -28.244 1.00 28.16 ? 461 ALA A C 1 ATOM 3498 O O . ALA A 1 461 ? 1.342 -25.461 -29.414 1.00 28.14 ? 461 ALA A O 1 ATOM 3499 C CB . ALA A 1 461 ? -0.160 -25.763 -26.587 1.00 26.51 ? 461 ALA A CB 1 ATOM 3500 N N . VAL A 1 462 ? 2.680 -26.460 -27.874 1.00 28.29 ? 462 VAL A N 1 ATOM 3501 C CA . VAL A 1 462 ? 3.266 -27.451 -28.746 1.00 29.65 ? 462 VAL A CA 1 ATOM 3502 C C . VAL A 1 462 ? 3.331 -28.825 -28.018 1.00 30.89 ? 462 VAL A C 1 ATOM 3503 O O . VAL A 1 462 ? 2.936 -28.965 -26.846 1.00 31.61 ? 462 VAL A O 1 ATOM 3504 C CB . VAL A 1 462 ? 4.692 -27.025 -29.238 1.00 29.56 ? 462 VAL A CB 1 ATOM 3505 C CG1 . VAL A 1 462 ? 4.608 -25.878 -30.234 1.00 29.25 ? 462 VAL A CG1 1 ATOM 3506 C CG2 . VAL A 1 462 ? 5.554 -26.650 -28.086 1.00 28.48 ? 462 VAL A CG2 1 ATOM 3507 N N . VAL A 1 463 ? 3.830 -29.840 -28.694 1.00 30.98 ? 463 VAL A N 1 ATOM 3508 C CA . VAL A 1 463 ? 3.936 -31.122 -28.055 1.00 31.78 ? 463 VAL A CA 1 ATOM 3509 C C . VAL A 1 463 ? 5.343 -31.649 -28.270 1.00 32.24 ? 463 VAL A C 1 ATOM 3510 O O . VAL A 1 463 ? 5.815 -31.715 -29.413 1.00 32.34 ? 463 VAL A O 1 ATOM 3511 C CB . VAL A 1 463 ? 2.881 -32.107 -28.583 1.00 31.82 ? 463 VAL A CB 1 ATOM 3512 C CG1 . VAL A 1 463 ? 3.087 -33.465 -27.958 1.00 32.17 ? 463 VAL A CG1 1 ATOM 3513 C CG2 . VAL A 1 463 ? 1.484 -31.592 -28.264 1.00 31.85 ? 463 VAL A CG2 1 ATOM 3514 N N . MET A 1 464 ? 6.013 -31.963 -27.166 1.00 32.38 ? 464 MET A N 1 ATOM 3515 C CA . MET A 1 464 ? 7.316 -32.565 -27.184 1.00 32.91 ? 464 MET A CA 1 ATOM 3516 C C . MET A 1 464 ? 7.050 -34.044 -27.225 1.00 33.07 ? 464 MET A C 1 ATOM 3517 O O . MET A 1 464 ? 6.609 -34.645 -26.225 1.00 33.08 ? 464 MET A O 1 ATOM 3518 C CB . MET A 1 464 ? 8.101 -32.212 -25.923 1.00 33.41 ? 464 MET A CB 1 ATOM 3519 C CG . MET A 1 464 ? 8.477 -30.732 -25.802 1.00 36.25 ? 464 MET A CG 1 ATOM 3520 S SD . MET A 1 464 ? 9.265 -30.027 -27.281 1.00 41.43 ? 464 MET A SD 1 ATOM 3521 C CE . MET A 1 464 ? 7.964 -29.100 -28.025 1.00 37.25 ? 464 MET A CE 1 ATOM 3522 N N . ALA A 1 465 ? 7.283 -34.620 -28.399 1.00 32.92 ? 465 ALA A N 1 ATOM 3523 C CA . ALA A 1 465 ? 7.062 -36.022 -28.619 1.00 33.24 ? 465 ALA A CA 1 ATOM 3524 C C . ALA A 1 465 ? 8.353 -36.733 -28.258 1.00 33.59 ? 465 ALA A C 1 ATOM 3525 O O . ALA A 1 465 ? 9.236 -36.921 -29.094 1.00 33.60 ? 465 ALA A O 1 ATOM 3526 C CB . ALA A 1 465 ? 6.673 -36.266 -30.064 1.00 33.25 ? 465 ALA A CB 1 ATOM 3527 N N . GLU A 1 466 ? 8.461 -37.133 -27.005 1.00 33.64 ? 466 GLU A N 1 ATOM 3528 C CA . GLU A 1 466 ? 9.744 -37.566 -26.492 1.00 34.46 ? 466 GLU A CA 1 ATOM 3529 C C . GLU A 1 466 ? 10.002 -39.047 -26.752 1.00 35.09 ? 466 GLU A C 1 ATOM 3530 O O . GLU A 1 466 ? 9.231 -39.892 -26.323 1.00 35.09 ? 466 GLU A O 1 ATOM 3531 C CB . GLU A 1 466 ? 9.848 -37.261 -24.991 1.00 34.05 ? 466 GLU A CB 1 ATOM 3532 C CG . GLU A 1 466 ? 11.192 -37.570 -24.402 1.00 32.84 ? 466 GLU A CG 1 ATOM 3533 C CD . GLU A 1 466 ? 11.410 -36.863 -23.088 1.00 33.19 ? 466 GLU A CD 1 ATOM 3534 O OE1 . GLU A 1 466 ? 12.224 -37.359 -22.301 1.00 34.20 ? 466 GLU A OE1 1 ATOM 3535 O OE2 . GLU A 1 466 ? 10.752 -35.838 -22.817 1.00 31.09 ? 466 GLU A OE2 1 ATOM 3536 N N . ASP A 1 467 ? 11.099 -39.341 -27.440 1.00 35.57 ? 467 ASP A N 1 ATOM 3537 C CA . ASP A 1 467 ? 11.554 -40.712 -27.628 1.00 36.34 ? 467 ASP A CA 1 ATOM 3538 C C . ASP A 1 467 ? 10.396 -41.596 -28.117 1.00 36.94 ? 467 ASP A C 1 ATOM 3539 O O . ASP A 1 467 ? 10.106 -42.644 -27.526 1.00 37.24 ? 467 ASP A O 1 ATOM 3540 C CB . ASP A 1 467 ? 12.191 -41.234 -26.329 1.00 35.58 ? 467 ASP A CB 1 ATOM 3541 C CG . ASP A 1 467 ? 12.896 -42.610 -26.484 1.00 36.46 ? 467 ASP A CG 1 ATOM 3542 O OD1 . ASP A 1 467 ? 13.204 -43.072 -27.612 1.00 37.33 ? 467 ASP A OD1 1 ATOM 3543 O OD2 . ASP A 1 467 ? 13.171 -43.232 -25.431 1.00 35.90 ? 467 ASP A OD2 1 ATOM 3544 N N . ILE A 1 468 ? 9.757 -41.164 -29.206 1.00 37.41 ? 468 ILE A N 1 ATOM 3545 C CA . ILE A 1 468 ? 8.602 -41.860 -29.785 1.00 38.33 ? 468 ILE A CA 1 ATOM 3546 C C . ILE A 1 468 ? 8.701 -43.408 -29.804 1.00 39.22 ? 468 ILE A C 1 ATOM 3547 O O . ILE A 1 468 ? 7.720 -44.095 -29.479 1.00 38.59 ? 468 ILE A O 1 ATOM 3548 C CB . ILE A 1 468 ? 8.299 -41.338 -31.207 1.00 38.25 ? 468 ILE A CB 1 ATOM 3549 C CG1 . ILE A 1 468 ? 7.725 -39.928 -31.141 1.00 38.03 ? 468 ILE A CG1 1 ATOM 3550 C CG2 . ILE A 1 468 ? 7.332 -42.272 -31.954 1.00 38.11 ? 468 ILE A CG2 1 ATOM 3551 C CD1 . ILE A 1 468 ? 7.465 -39.321 -32.505 1.00 36.43 ? 468 ILE A CD1 1 ATOM 3552 N N . PRO A 1 469 ? 9.883 -43.960 -30.176 1.00 40.17 ? 469 PRO A N 1 ATOM 3553 C CA . PRO A 1 469 ? 9.965 -45.409 -30.345 1.00 40.63 ? 469 PRO A CA 1 ATOM 3554 C C . PRO A 1 469 ? 9.835 -46.212 -29.059 1.00 40.61 ? 469 PRO A C 1 ATOM 3555 O O . PRO A 1 469 ? 9.532 -47.395 -29.127 1.00 40.76 ? 469 PRO A O 1 ATOM 3556 C CB . PRO A 1 469 ? 11.366 -45.610 -30.964 1.00 40.88 ? 469 PRO A CB 1 ATOM 3557 C CG . PRO A 1 469 ? 11.724 -44.270 -31.536 1.00 40.48 ? 469 PRO A CG 1 ATOM 3558 C CD . PRO A 1 469 ? 11.185 -43.342 -30.498 1.00 40.62 ? 469 PRO A CD 1 ATOM 3559 N N . GLU A 1 470 ? 10.059 -45.581 -27.908 1.00 40.76 ? 470 GLU A N 1 ATOM 3560 C CA . GLU A 1 470 ? 9.966 -46.281 -26.620 1.00 40.46 ? 470 GLU A CA 1 ATOM 3561 C C . GLU A 1 470 ? 8.699 -46.009 -25.805 1.00 39.51 ? 470 GLU A C 1 ATOM 3562 O O . GLU A 1 470 ? 8.522 -46.587 -24.719 1.00 39.09 ? 470 GLU A O 1 ATOM 3563 C CB . GLU A 1 470 ? 11.190 -46.001 -25.768 1.00 41.11 ? 470 GLU A CB 1 ATOM 3564 C CG . GLU A 1 470 ? 12.450 -46.647 -26.273 1.00 44.40 ? 470 GLU A CG 1 ATOM 3565 C CD . GLU A 1 470 ? 12.543 -48.097 -25.902 1.00 48.78 ? 470 GLU A CD 1 ATOM 3566 O OE1 . GLU A 1 470 ? 13.667 -48.621 -26.010 1.00 52.45 ? 470 GLU A OE1 1 ATOM 3567 O OE2 . GLU A 1 470 ? 11.521 -48.709 -25.500 1.00 48.76 ? 470 GLU A OE2 1 ATOM 3568 N N . VAL A 1 471 ? 7.812 -45.174 -26.346 1.00 38.53 ? 471 VAL A N 1 ATOM 3569 C CA . VAL A 1 471 ? 6.594 -44.757 -25.646 1.00 37.64 ? 471 VAL A CA 1 ATOM 3570 C C . VAL A 1 471 ? 5.713 -45.958 -25.307 1.00 37.41 ? 471 VAL A C 1 ATOM 3571 O O . VAL A 1 471 ? 5.337 -46.148 -24.146 1.00 37.18 ? 471 VAL A O 1 ATOM 3572 C CB . VAL A 1 471 ? 5.795 -43.664 -26.428 1.00 37.32 ? 471 VAL A CB 1 ATOM 3573 C CG1 . VAL A 1 471 ? 4.483 -43.388 -25.753 1.00 37.24 ? 471 VAL A CG1 1 ATOM 3574 C CG2 . VAL A 1 471 ? 6.595 -42.373 -26.514 1.00 35.61 ? 471 VAL A CG2 1 ATOM 3575 N N . ALA A 1 472 ? 5.403 -46.775 -26.307 1.00 37.51 ? 472 ALA A N 1 ATOM 3576 C CA . ALA A 1 472 ? 4.519 -47.916 -26.084 1.00 38.03 ? 472 ALA A CA 1 ATOM 3577 C C . ALA A 1 472 ? 5.082 -48.897 -25.064 1.00 38.26 ? 472 ALA A C 1 ATOM 3578 O O . ALA A 1 472 ? 4.350 -49.313 -24.170 1.00 38.49 ? 472 ALA A O 1 ATOM 3579 C CB . ALA A 1 472 ? 4.149 -48.618 -27.377 1.00 38.38 ? 472 ALA A CB 1 ATOM 3580 N N . ALA A 1 473 ? 6.371 -49.228 -25.168 1.00 38.22 ? 473 ALA A N 1 ATOM 3581 C CA . ALA A 1 473 ? 7.026 -50.123 -24.191 1.00 38.45 ? 473 ALA A CA 1 ATOM 3582 C C . ALA A 1 473 ? 7.123 -49.520 -22.776 1.00 39.06 ? 473 ALA A C 1 ATOM 3583 O O . ALA A 1 473 ? 6.940 -50.230 -21.792 1.00 39.48 ? 473 ALA A O 1 ATOM 3584 C CB . ALA A 1 473 ? 8.409 -50.512 -24.682 1.00 38.11 ? 473 ALA A CB 1 ATOM 3585 N N . THR A 1 474 ? 7.420 -48.210 -22.688 1.00 39.21 ? 474 THR A N 1 ATOM 3586 C CA . THR A 1 474 ? 7.646 -47.515 -21.412 1.00 38.47 ? 474 THR A CA 1 ATOM 3587 C C . THR A 1 474 ? 6.363 -47.182 -20.634 1.00 37.91 ? 474 THR A C 1 ATOM 3588 O O . THR A 1 474 ? 6.403 -47.097 -19.400 1.00 38.58 ? 474 THR A O 1 ATOM 3589 C CB . THR A 1 474 ? 8.470 -46.213 -21.609 1.00 38.34 ? 474 THR A CB 1 ATOM 3590 O OG1 . THR A 1 474 ? 9.669 -46.538 -22.287 1.00 39.56 ? 474 THR A OG1 1 ATOM 3591 C CG2 . THR A 1 474 ? 8.874 -45.567 -20.272 1.00 38.62 ? 474 THR A CG2 1 ATOM 3592 N N . ASN A 1 475 ? 5.253 -46.973 -21.342 1.00 36.46 ? 475 ASN A N 1 ATOM 3593 C CA . ASN A 1 475 ? 3.992 -46.572 -20.719 1.00 35.37 ? 475 ASN A CA 1 ATOM 3594 C C . ASN A 1 475 ? 2.911 -47.615 -21.011 1.00 35.07 ? 475 ASN A C 1 ATOM 3595 O O . ASN A 1 475 ? 1.973 -47.336 -21.751 1.00 34.76 ? 475 ASN A O 1 ATOM 3596 C CB . ASN A 1 475 ? 3.531 -45.198 -21.256 1.00 35.11 ? 475 ASN A CB 1 ATOM 3597 C CG . ASN A 1 475 ? 4.566 -44.096 -21.042 1.00 35.86 ? 475 ASN A CG 1 ATOM 3598 O OD1 . ASN A 1 475 ? 4.643 -43.502 -19.960 1.00 34.20 ? 475 ASN A OD1 1 ATOM 3599 N ND2 . ASN A 1 475 ? 5.385 -43.828 -22.081 1.00 35.23 ? 475 ASN A ND2 1 ATOM 3600 N N . PRO A 1 476 ? 3.034 -48.840 -20.459 1.00 34.78 ? 476 PRO A N 1 ATOM 3601 C CA . PRO A 1 476 ? 1.851 -49.670 -20.709 1.00 33.91 ? 476 PRO A CA 1 ATOM 3602 C C . PRO A 1 476 ? 0.615 -48.983 -20.096 1.00 33.37 ? 476 PRO A C 1 ATOM 3603 O O . PRO A 1 476 ? 0.670 -48.527 -18.941 1.00 32.35 ? 476 PRO A O 1 ATOM 3604 C CB . PRO A 1 476 ? 2.179 -50.990 -19.975 1.00 33.91 ? 476 PRO A CB 1 ATOM 3605 C CG . PRO A 1 476 ? 3.278 -50.620 -18.958 1.00 34.10 ? 476 PRO A CG 1 ATOM 3606 C CD . PRO A 1 476 ? 4.065 -49.539 -19.647 1.00 34.73 ? 476 PRO A CD 1 ATOM 3607 N N . VAL A 1 477 ? -0.466 -48.893 -20.868 1.00 32.86 ? 477 VAL A N 1 ATOM 3608 C CA . VAL A 1 477 ? -1.706 -48.314 -20.379 1.00 32.52 ? 477 VAL A CA 1 ATOM 3609 C C . VAL A 1 477 ? -2.645 -49.337 -19.703 1.00 33.37 ? 477 VAL A C 1 ATOM 3610 O O . VAL A 1 477 ? -2.587 -50.541 -20.006 1.00 34.01 ? 477 VAL A O 1 ATOM 3611 C CB . VAL A 1 477 ? -2.405 -47.535 -21.458 1.00 32.21 ? 477 VAL A CB 1 ATOM 3612 C CG1 . VAL A 1 477 ? -1.439 -46.594 -22.059 1.00 31.80 ? 477 VAL A CG1 1 ATOM 3613 C CG2 . VAL A 1 477 ? -2.978 -48.444 -22.546 1.00 33.12 ? 477 VAL A CG2 1 ATOM 3614 N N . PRO A 1 478 ? -3.476 -48.872 -18.739 1.00 33.62 ? 478 PRO A N 1 ATOM 3615 C CA . PRO A 1 478 ? -4.433 -49.774 -18.107 1.00 33.18 ? 478 PRO A CA 1 ATOM 3616 C C . PRO A 1 478 ? -5.693 -49.903 -18.953 1.00 33.31 ? 478 PRO A C 1 ATOM 3617 O O . PRO A 1 478 ? -5.999 -49.015 -19.763 1.00 34.32 ? 478 PRO A O 1 ATOM 3618 C CB . PRO A 1 478 ? -4.755 -49.059 -16.803 1.00 33.01 ? 478 PRO A CB 1 ATOM 3619 C CG . PRO A 1 478 ? -4.631 -47.590 -17.157 1.00 33.77 ? 478 PRO A CG 1 ATOM 3620 C CD . PRO A 1 478 ? -3.562 -47.494 -18.196 1.00 33.36 ? 478 PRO A CD 1 ATOM 3621 N N . GLN A 1 479 ? -6.437 -50.986 -18.764 1.00 33.00 ? 479 GLN A N 1 ATOM 3622 C CA . GLN A 1 479 ? -7.692 -51.187 -19.496 1.00 32.03 ? 479 GLN A CA 1 ATOM 3623 C C . GLN A 1 479 ? -8.496 -49.905 -19.531 1.00 32.04 ? 479 GLN A C 1 ATOM 3624 O O . GLN A 1 479 ? -8.872 -49.438 -20.588 1.00 32.27 ? 479 GLN A O 1 ATOM 3625 C CB . GLN A 1 479 ? -8.512 -52.314 -18.859 1.00 31.60 ? 479 GLN A CB 1 ATOM 3626 C CG . GLN A 1 479 ? -9.709 -52.807 -19.684 1.00 32.83 ? 479 GLN A CG 1 ATOM 3627 C CD . GLN A 1 479 ? -9.402 -52.941 -21.185 1.00 33.90 ? 479 GLN A CD 1 ATOM 3628 O OE1 . GLN A 1 479 ? -10.073 -52.315 -22.012 1.00 32.06 ? 479 GLN A OE1 1 ATOM 3629 N NE2 . GLN A 1 479 ? -8.383 -53.756 -21.534 1.00 31.45 ? 479 GLN A NE2 1 ATOM 3630 N N . ALA A 1 480 ? -8.735 -49.321 -18.360 1.00 32.25 ? 480 ALA A N 1 ATOM 3631 C CA . ALA A 1 480 ? -9.612 -48.151 -18.222 1.00 31.76 ? 480 ALA A CA 1 ATOM 3632 C C . ALA A 1 480 ? -9.213 -46.934 -19.114 1.00 31.94 ? 480 ALA A C 1 ATOM 3633 O O . ALA A 1 480 ? -10.097 -46.173 -19.605 1.00 32.43 ? 480 ALA A O 1 ATOM 3634 C CB . ALA A 1 480 ? -9.704 -47.765 -16.753 1.00 31.03 ? 480 ALA A CB 1 ATOM 3635 N N . TRP A 1 481 ? -7.908 -46.765 -19.354 1.00 30.90 ? 481 TRP A N 1 ATOM 3636 C CA . TRP A 1 481 ? -7.450 -45.685 -20.198 1.00 30.33 ? 481 TRP A CA 1 ATOM 3637 C C . TRP A 1 481 ? -7.836 -45.972 -21.622 1.00 30.29 ? 481 TRP A C 1 ATOM 3638 O O . TRP A 1 481 ? -8.236 -45.069 -22.335 1.00 31.54 ? 481 TRP A O 1 ATOM 3639 C CB . TRP A 1 481 ? -5.937 -45.453 -20.076 1.00 30.75 ? 481 TRP A CB 1 ATOM 3640 C CG . TRP A 1 481 ? -5.402 -44.350 -20.984 1.00 30.16 ? 481 TRP A CG 1 ATOM 3641 C CD1 . TRP A 1 481 ? -5.202 -43.046 -20.654 1.00 30.35 ? 481 TRP A CD1 1 ATOM 3642 C CD2 . TRP A 1 481 ? -5.004 -44.470 -22.356 1.00 30.77 ? 481 TRP A CD2 1 ATOM 3643 N NE1 . TRP A 1 481 ? -4.719 -42.341 -21.723 1.00 29.42 ? 481 TRP A NE1 1 ATOM 3644 C CE2 . TRP A 1 481 ? -4.575 -43.194 -22.779 1.00 31.06 ? 481 TRP A CE2 1 ATOM 3645 C CE3 . TRP A 1 481 ? -4.985 -45.526 -23.275 1.00 30.95 ? 481 TRP A CE3 1 ATOM 3646 C CZ2 . TRP A 1 481 ? -4.123 -42.950 -24.080 1.00 32.03 ? 481 TRP A CZ2 1 ATOM 3647 C CZ3 . TRP A 1 481 ? -4.523 -45.284 -24.576 1.00 30.78 ? 481 TRP A CZ3 1 ATOM 3648 C CH2 . TRP A 1 481 ? -4.101 -44.011 -24.960 1.00 31.07 ? 481 TRP A CH2 1 ATOM 3649 N N . SER A 1 482 ? -7.727 -47.229 -22.044 1.00 29.97 ? 482 SER A N 1 ATOM 3650 C CA . SER A 1 482 ? -8.074 -47.627 -23.407 1.00 29.07 ? 482 SER A CA 1 ATOM 3651 C C . SER A 1 482 ? -9.557 -47.381 -23.695 1.00 29.13 ? 482 SER A C 1 ATOM 3652 O O . SER A 1 482 ? -9.944 -47.091 -24.845 1.00 28.30 ? 482 SER A O 1 ATOM 3653 C CB . SER A 1 482 ? -7.705 -49.098 -23.611 1.00 29.26 ? 482 SER A CB 1 ATOM 3654 O OG . SER A 1 482 ? -8.180 -49.648 -24.837 1.00 29.74 ? 482 SER A OG 1 ATOM 3655 N N . ASP A 1 483 ? -10.378 -47.492 -22.650 1.00 28.92 ? 483 ASP A N 1 ATOM 3656 C CA . ASP A 1 483 ? -11.821 -47.327 -22.797 1.00 29.83 ? 483 ASP A CA 1 ATOM 3657 C C . ASP A 1 483 ? -12.308 -45.883 -22.754 1.00 30.06 ? 483 ASP A C 1 ATOM 3658 O O . ASP A 1 483 ? -13.449 -45.621 -23.097 1.00 30.52 ? 483 ASP A O 1 ATOM 3659 C CB . ASP A 1 483 ? -12.605 -48.183 -21.794 1.00 29.86 ? 483 ASP A CB 1 ATOM 3660 C CG . ASP A 1 483 ? -12.402 -49.713 -21.997 1.00 32.06 ? 483 ASP A CG 1 ATOM 3661 O OD1 . ASP A 1 483 ? -12.336 -50.393 -20.957 1.00 34.16 ? 483 ASP A OD1 1 ATOM 3662 O OD2 . ASP A 1 483 ? -12.322 -50.232 -23.154 1.00 30.54 ? 483 ASP A OD2 1 ATOM 3663 N N . LEU A 1 484 ? -11.450 -44.945 -22.348 1.00 30.48 ? 484 LEU A N 1 ATOM 3664 C CA . LEU A 1 484 ? -11.823 -43.526 -22.235 1.00 29.08 ? 484 LEU A CA 1 ATOM 3665 C C . LEU A 1 484 ? -12.328 -43.002 -23.537 1.00 29.67 ? 484 LEU A C 1 ATOM 3666 O O . LEU A 1 484 ? -13.422 -42.434 -23.582 1.00 30.19 ? 484 LEU A O 1 ATOM 3667 C CB . LEU A 1 484 ? -10.645 -42.675 -21.757 1.00 28.58 ? 484 LEU A CB 1 ATOM 3668 C CG . LEU A 1 484 ? -10.414 -42.692 -20.261 1.00 26.59 ? 484 LEU A CG 1 ATOM 3669 C CD1 . LEU A 1 484 ? -9.080 -42.037 -19.911 1.00 24.37 ? 484 LEU A CD1 1 ATOM 3670 C CD2 . LEU A 1 484 ? -11.608 -42.022 -19.537 1.00 25.99 ? 484 LEU A CD2 1 ATOM 3671 N N . CYS A 1 485 ? -11.554 -43.213 -24.603 1.00 30.67 ? 485 CYS A N 1 ATOM 3672 C CA . CYS A 1 485 ? -11.901 -42.687 -25.935 1.00 31.74 ? 485 CYS A CA 1 ATOM 3673 C C . CYS A 1 485 ? -13.143 -43.311 -26.552 1.00 32.50 ? 485 CYS A C 1 ATOM 3674 O O . CYS A 1 485 ? -14.054 -42.591 -26.945 1.00 33.46 ? 485 CYS A O 1 ATOM 3675 C CB . CYS A 1 485 ? -10.728 -42.723 -26.909 1.00 31.38 ? 485 CYS A CB 1 ATOM 3676 S SG . CYS A 1 485 ? -9.392 -41.506 -26.584 1.00 32.37 ? 485 CYS A SG 1 ATOM 3677 N N . PRO A 1 486 ? -13.209 -44.644 -26.625 1.00 33.24 ? 486 PRO A N 1 ATOM 3678 C CA . PRO A 1 486 ? -14.437 -45.174 -27.207 1.00 33.40 ? 486 PRO A CA 1 ATOM 3679 C C . PRO A 1 486 ? -15.667 -44.603 -26.500 1.00 33.05 ? 486 PRO A C 1 ATOM 3680 O O . PRO A 1 486 ? -16.601 -44.161 -27.178 1.00 33.40 ? 486 PRO A O 1 ATOM 3681 C CB . PRO A 1 486 ? -14.308 -46.692 -26.977 1.00 33.81 ? 486 PRO A CB 1 ATOM 3682 C CG . PRO A 1 486 ? -12.795 -46.931 -26.957 1.00 33.76 ? 486 PRO A CG 1 ATOM 3683 C CD . PRO A 1 486 ? -12.282 -45.719 -26.211 1.00 33.60 ? 486 PRO A CD 1 ATOM 3684 N N . THR A 1 487 ? -15.650 -44.588 -25.165 1.00 33.01 ? 487 THR A N 1 ATOM 3685 C CA . THR A 1 487 ? -16.720 -43.977 -24.339 1.00 32.89 ? 487 THR A CA 1 ATOM 3686 C C . THR A 1 487 ? -16.961 -42.489 -24.647 1.00 33.39 ? 487 THR A C 1 ATOM 3687 O O . THR A 1 487 ? -18.105 -42.074 -24.806 1.00 33.53 ? 487 THR A O 1 ATOM 3688 C CB . THR A 1 487 ? -16.432 -44.089 -22.834 1.00 33.21 ? 487 THR A CB 1 ATOM 3689 O OG1 . THR A 1 487 ? -16.361 -45.474 -22.419 1.00 31.54 ? 487 THR A OG1 1 ATOM 3690 C CG2 . THR A 1 487 ? -17.508 -43.330 -22.034 1.00 32.76 ? 487 THR A CG2 1 ATOM 3691 N N . TYR A 1 488 ? -15.894 -41.689 -24.745 1.00 33.44 ? 488 TYR A N 1 ATOM 3692 C CA . TYR A 1 488 ? -16.061 -40.261 -25.015 1.00 33.43 ? 488 TYR A CA 1 ATOM 3693 C C . TYR A 1 488 ? -16.553 -39.983 -26.429 1.00 34.56 ? 488 TYR A C 1 ATOM 3694 O O . TYR A 1 488 ? -17.397 -39.093 -26.630 1.00 34.73 ? 488 TYR A O 1 ATOM 3695 C CB . TYR A 1 488 ? -14.777 -39.465 -24.736 1.00 32.40 ? 488 TYR A CB 1 ATOM 3696 C CG . TYR A 1 488 ? -14.879 -37.965 -24.993 1.00 29.23 ? 488 TYR A CG 1 ATOM 3697 C CD1 . TYR A 1 488 ? -14.472 -37.422 -26.194 1.00 26.77 ? 488 TYR A CD1 1 ATOM 3698 C CD2 . TYR A 1 488 ? -15.367 -37.097 -24.011 1.00 30.66 ? 488 TYR A CD2 1 ATOM 3699 C CE1 . TYR A 1 488 ? -14.556 -36.056 -26.424 1.00 29.20 ? 488 TYR A CE1 1 ATOM 3700 C CE2 . TYR A 1 488 ? -15.454 -35.696 -24.218 1.00 27.99 ? 488 TYR A CE2 1 ATOM 3701 C CZ . TYR A 1 488 ? -15.044 -35.196 -25.421 1.00 30.17 ? 488 TYR A CZ 1 ATOM 3702 O OH . TYR A 1 488 ? -15.128 -33.850 -25.662 1.00 29.93 ? 488 TYR A OH 1 ATOM 3703 N N . ASP A 1 489 ? -16.022 -40.706 -27.411 1.00 35.67 ? 489 ASP A N 1 ATOM 3704 C CA . ASP A 1 489 ? -16.435 -40.459 -28.797 1.00 37.55 ? 489 ASP A CA 1 ATOM 3705 C C . ASP A 1 489 ? -17.922 -40.809 -29.087 1.00 38.03 ? 489 ASP A C 1 ATOM 3706 O O . ASP A 1 489 ? -18.527 -40.278 -30.032 1.00 38.11 ? 489 ASP A O 1 ATOM 3707 C CB . ASP A 1 489 ? -15.480 -41.122 -29.777 1.00 37.79 ? 489 ASP A CB 1 ATOM 3708 C CG . ASP A 1 489 ? -14.102 -40.481 -29.778 1.00 39.23 ? 489 ASP A CG 1 ATOM 3709 O OD1 . ASP A 1 489 ? -14.011 -39.259 -29.538 1.00 42.01 ? 489 ASP A OD1 1 ATOM 3710 O OD2 . ASP A 1 489 ? -13.110 -41.192 -30.054 1.00 40.35 ? 489 ASP A OD2 1 ATOM 3711 N N . ALA A 1 490 ? -18.493 -41.663 -28.235 1.00 38.84 ? 490 ALA A N 1 ATOM 3712 C CA . ALA A 1 490 ? -19.880 -42.112 -28.339 1.00 39.33 ? 490 ALA A CA 1 ATOM 3713 C C . ALA A 1 490 ? -20.867 -41.081 -27.820 1.00 40.39 ? 490 ALA A C 1 ATOM 3714 O O . ALA A 1 490 ? -22.088 -41.280 -27.961 1.00 40.28 ? 490 ALA A O 1 ATOM 3715 C CB . ALA A 1 490 ? -20.067 -43.404 -27.580 1.00 38.69 ? 490 ALA A CB 1 ATOM 3716 N N . LEU A 1 491 ? -20.356 -40.007 -27.192 1.00 40.93 ? 491 LEU A N 1 ATOM 3717 C CA . LEU A 1 491 ? -21.226 -38.998 -26.575 1.00 41.09 ? 491 LEU A CA 1 ATOM 3718 C C . LEU A 1 491 ? -21.796 -38.087 -27.619 1.00 41.61 ? 491 LEU A C 1 ATOM 3719 O O . LEU A 1 491 ? -21.174 -37.849 -28.644 1.00 41.03 ? 491 LEU A O 1 ATOM 3720 C CB . LEU A 1 491 ? -20.495 -38.136 -25.549 1.00 41.00 ? 491 LEU A CB 1 ATOM 3721 C CG . LEU A 1 491 ? -19.985 -38.689 -24.220 1.00 40.25 ? 491 LEU A CG 1 ATOM 3722 C CD1 . LEU A 1 491 ? -19.336 -37.563 -23.433 1.00 37.80 ? 491 LEU A CD1 1 ATOM 3723 C CD2 . LEU A 1 491 ? -21.090 -39.341 -23.416 1.00 40.84 ? 491 LEU A CD2 1 ATOM 3724 N N . SER A 1 492 ? -22.999 -37.599 -27.335 1.00 42.84 ? 492 SER A N 1 ATOM 3725 C CA . SER A 1 492 ? -23.603 -36.467 -28.038 1.00 44.20 ? 492 SER A CA 1 ATOM 3726 C C . SER A 1 492 ? -22.860 -35.154 -27.716 1.00 44.48 ? 492 SER A C 1 ATOM 3727 O O . SER A 1 492 ? -22.387 -34.966 -26.605 1.00 44.00 ? 492 SER A O 1 ATOM 3728 C CB . SER A 1 492 ? -25.094 -36.376 -27.668 1.00 44.35 ? 492 SER A CB 1 ATOM 3729 O OG . SER A 1 492 ? -25.574 -35.045 -27.736 1.00 45.90 ? 492 SER A OG 1 ATOM 3730 N N . PRO A 1 493 ? -22.745 -34.247 -28.695 1.00 45.66 ? 493 PRO A N 1 ATOM 3731 C CA . PRO A 1 493 ? -22.005 -32.988 -28.423 1.00 46.71 ? 493 PRO A CA 1 ATOM 3732 C C . PRO A 1 493 ? -22.409 -32.151 -27.179 1.00 47.24 ? 493 PRO A C 1 ATOM 3733 O O . PRO A 1 493 ? -21.621 -31.323 -26.720 1.00 47.26 ? 493 PRO A O 1 ATOM 3734 C CB . PRO A 1 493 ? -22.170 -32.182 -29.734 1.00 46.59 ? 493 PRO A CB 1 ATOM 3735 C CG . PRO A 1 493 ? -22.322 -33.240 -30.786 1.00 46.19 ? 493 PRO A CG 1 ATOM 3736 C CD . PRO A 1 493 ? -23.201 -34.309 -30.096 1.00 45.61 ? 493 PRO A CD 1 ATOM 3737 N N . ASP A 1 494 ? -23.599 -32.348 -26.626 1.00 47.91 ? 494 ASP A N 1 ATOM 3738 C CA . ASP A 1 494 ? -23.942 -31.554 -25.444 1.00 48.48 ? 494 ASP A CA 1 ATOM 3739 C C . ASP A 1 494 ? -23.973 -32.359 -24.150 1.00 48.05 ? 494 ASP A C 1 ATOM 3740 O O . ASP A 1 494 ? -24.359 -31.861 -23.093 1.00 48.13 ? 494 ASP A O 1 ATOM 3741 C CB . ASP A 1 494 ? -25.184 -30.672 -25.658 1.00 49.34 ? 494 ASP A CB 1 ATOM 3742 C CG . ASP A 1 494 ? -26.099 -31.195 -26.752 1.00 52.11 ? 494 ASP A CG 1 ATOM 3743 O OD1 . ASP A 1 494 ? -26.578 -32.347 -26.624 1.00 54.02 ? 494 ASP A OD1 1 ATOM 3744 O OD2 . ASP A 1 494 ? -26.333 -30.449 -27.738 1.00 54.69 ? 494 ASP A OD2 1 ATOM 3745 N N . ASP A 1 495 ? -23.528 -33.610 -24.241 1.00 47.29 ? 495 ASP A N 1 ATOM 3746 C CA . ASP A 1 495 ? -23.081 -34.316 -23.058 1.00 46.66 ? 495 ASP A CA 1 ATOM 3747 C C . ASP A 1 495 ? -21.554 -34.226 -22.875 1.00 45.30 ? 495 ASP A C 1 ATOM 3748 O O . ASP A 1 495 ? -21.008 -34.869 -21.996 1.00 45.31 ? 495 ASP A O 1 ATOM 3749 C CB . ASP A 1 495 ? -23.563 -35.779 -23.054 1.00 47.64 ? 495 ASP A CB 1 ATOM 3750 C CG . ASP A 1 495 ? -25.090 -35.899 -22.977 1.00 49.56 ? 495 ASP A CG 1 ATOM 3751 O OD1 . ASP A 1 495 ? -25.760 -34.841 -22.907 1.00 51.62 ? 495 ASP A OD1 1 ATOM 3752 O OD2 . ASP A 1 495 ? -25.614 -37.043 -23.004 1.00 49.69 ? 495 ASP A OD2 1 ATOM 3753 N N . GLN A 1 496 ? -20.877 -33.408 -23.675 1.00 43.85 ? 496 GLN A N 1 ATOM 3754 C CA . GLN A 1 496 ? -19.414 -33.338 -23.643 1.00 43.11 ? 496 GLN A CA 1 ATOM 3755 C C . GLN A 1 496 ? -18.872 -32.561 -22.450 1.00 42.11 ? 496 GLN A C 1 ATOM 3756 O O . GLN A 1 496 ? -19.529 -31.646 -21.991 1.00 41.80 ? 496 GLN A O 1 ATOM 3757 C CB . GLN A 1 496 ? -18.861 -32.791 -24.967 1.00 42.55 ? 496 GLN A CB 1 ATOM 3758 C CG . GLN A 1 496 ? -18.654 -33.874 -25.993 1.00 42.36 ? 496 GLN A CG 1 ATOM 3759 C CD . GLN A 1 496 ? -18.224 -33.376 -27.387 1.00 43.25 ? 496 GLN A CD 1 ATOM 3760 O OE1 . GLN A 1 496 ? -18.243 -32.163 -27.705 1.00 42.54 ? 496 GLN A OE1 1 ATOM 3761 N NE2 . GLN A 1 496 ? -17.828 -34.329 -28.223 1.00 40.82 ? 496 GLN A NE2 1 HETATM 3762 C C1A . CBS B 2 . ? -25.340 -18.811 -15.773 1.00 33.67 ? 1001 CBS A C1A 1 HETATM 3763 C C2A . CBS B 2 . ? -24.461 -17.591 -15.501 1.00 32.86 ? 1001 CBS A C2A 1 HETATM 3764 C C3A . CBS B 2 . ? -25.150 -16.216 -15.520 1.00 33.96 ? 1001 CBS A C3A 1 HETATM 3765 C C4A . CBS B 2 . ? -26.460 -16.023 -16.319 1.00 36.87 ? 1001 CBS A C4A 1 HETATM 3766 C C5A . CBS B 2 . ? -27.259 -17.302 -16.587 1.00 35.91 ? 1001 CBS A C5A 1 HETATM 3767 C C6A . CBS B 2 . ? -27.746 -17.364 -18.013 1.00 37.58 ? 1001 CBS A C6A 1 HETATM 3768 C C7A . CBS B 2 . ? -22.150 -18.230 -14.769 1.00 25.29 ? 1001 CBS A C7A 1 HETATM 3769 C C8A . CBS B 2 . ? -21.230 -18.200 -13.548 1.00 22.67 ? 1001 CBS A C8A 1 HETATM 3770 N N2A . CBS B 2 . ? -23.509 -17.847 -14.433 1.00 30.39 ? 1001 CBS A N2A 1 HETATM 3771 O O1A . CBS B 2 . ? -24.592 -19.825 -16.444 1.00 31.64 ? 1001 CBS A O1A 1 HETATM 3772 O O3A . CBS B 2 . ? -24.229 -15.149 -15.470 1.00 34.72 ? 1001 CBS A O3A 1 HETATM 3773 O O4A . CBS B 2 . ? -27.297 -14.868 -16.091 1.00 40.10 ? 1001 CBS A O4A 1 HETATM 3774 O O5A . CBS B 2 . ? -26.635 -18.578 -16.385 1.00 35.63 ? 1001 CBS A O5A 1 HETATM 3775 O O6A . CBS B 2 . ? -28.848 -18.260 -17.903 1.00 39.43 ? 1001 CBS A O6A 1 HETATM 3776 O O7A . CBS B 2 . ? -21.723 -17.345 -15.767 1.00 20.86 ? 1001 CBS A O7A 1 HETATM 3777 C C1B . CBS B 2 . ? -24.297 -23.969 -15.601 1.00 24.77 ? 1001 CBS A C1B 1 HETATM 3778 C C2B . CBS B 2 . ? -25.589 -23.301 -15.229 1.00 29.19 ? 1001 CBS A C2B 1 HETATM 3779 C C3B . CBS B 2 . ? -25.757 -21.828 -15.502 1.00 28.92 ? 1001 CBS A C3B 1 HETATM 3780 C C4B . CBS B 2 . ? -24.482 -20.982 -15.652 1.00 27.85 ? 1001 CBS A C4B 1 HETATM 3781 C C5B . CBS B 2 . ? -23.209 -21.744 -16.052 1.00 28.44 ? 1001 CBS A C5B 1 HETATM 3782 C C6B . CBS B 2 . ? -21.901 -21.097 -15.604 1.00 26.59 ? 1001 CBS A C6B 1 HETATM 3783 C C7B . CBS B 2 . ? -27.396 -24.779 -14.472 1.00 36.81 ? 1001 CBS A C7B 1 HETATM 3784 C C8B . CBS B 2 . ? -28.870 -24.854 -14.825 1.00 35.97 ? 1001 CBS A C8B 1 HETATM 3785 N N2B . CBS B 2 . ? -26.759 -24.072 -15.566 1.00 33.63 ? 1001 CBS A N2B 1 HETATM 3786 O O3B . CBS B 2 . ? -26.938 -21.365 -14.850 1.00 29.61 ? 1001 CBS A O3B 1 HETATM 3787 O O5B . CBS B 2 . ? -23.174 -23.188 -15.880 1.00 26.91 ? 1001 CBS A O5B 1 HETATM 3788 O O6B . CBS B 2 . ? -21.434 -21.639 -14.363 1.00 28.22 ? 1001 CBS A O6B 1 HETATM 3789 O O7B . CBS B 2 . ? -27.208 -24.099 -13.223 1.00 37.06 ? 1001 CBS A O7B 1 HETATM 3790 C C1A . CBS C 2 . ? 19.849 -18.644 -32.374 1.00 51.59 ? 1006 CBS A C1A 1 HETATM 3791 C C2A . CBS C 2 . ? 19.912 -19.848 -33.307 1.00 52.64 ? 1006 CBS A C2A 1 HETATM 3792 C C3A . CBS C 2 . ? 21.092 -19.957 -34.281 1.00 54.59 ? 1006 CBS A C3A 1 HETATM 3793 C C4A . CBS C 2 . ? 21.994 -18.722 -34.470 1.00 56.70 ? 1006 CBS A C4A 1 HETATM 3794 C C5A . CBS C 2 . ? 21.835 -17.519 -33.495 1.00 57.12 ? 1006 CBS A C5A 1 HETATM 3795 C C6A . CBS C 2 . ? 22.085 -16.136 -34.138 1.00 57.58 ? 1006 CBS A C6A 1 HETATM 3796 C C7A . CBS C 2 . ? 18.331 -21.461 -32.244 1.00 48.85 ? 1006 CBS A C7A 1 HETATM 3797 C C8A . CBS C 2 . ? 18.295 -22.982 -32.214 1.00 49.36 ? 1006 CBS A C8A 1 HETATM 3798 N N2A . CBS C 2 . ? 19.693 -21.030 -32.514 1.00 50.50 ? 1006 CBS A N2A 1 HETATM 3799 O O1A . CBS C 2 . ? 18.501 -18.336 -32.037 1.00 51.21 ? 1006 CBS A O1A 1 HETATM 3800 O O3A . CBS C 2 . ? 20.667 -20.432 -35.541 1.00 54.83 ? 1006 CBS A O3A 1 HETATM 3801 O O4A . CBS C 2 . ? 23.351 -19.149 -34.604 1.00 58.23 ? 1006 CBS A O4A 1 HETATM 3802 O O5A . CBS C 2 . ? 20.695 -17.500 -32.587 1.00 54.96 ? 1006 CBS A O5A 1 HETATM 3803 O O6A . CBS C 2 . ? 20.995 -15.690 -34.942 1.00 57.95 ? 1006 CBS A O6A 1 HETATM 3804 O O7A . CBS C 2 . ? 17.416 -20.989 -33.228 1.00 47.80 ? 1006 CBS A O7A 1 HETATM 3805 C C1B . CBS C 2 . ? 17.278 -16.234 -28.573 1.00 42.68 ? 1006 CBS A C1B 1 HETATM 3806 C C2B . CBS C 2 . ? 17.333 -15.401 -29.848 1.00 43.96 ? 1006 CBS A C2B 1 HETATM 3807 C C3B . CBS C 2 . ? 17.815 -16.133 -31.096 1.00 45.78 ? 1006 CBS A C3B 1 HETATM 3808 C C4B . CBS C 2 . ? 18.512 -17.498 -30.878 1.00 46.89 ? 1006 CBS A C4B 1 HETATM 3809 C C5B . CBS C 2 . ? 18.379 -18.264 -29.553 1.00 44.99 ? 1006 CBS A C5B 1 HETATM 3810 C C6B . CBS C 2 . ? 19.608 -19.119 -29.149 1.00 45.20 ? 1006 CBS A C6B 1 HETATM 3811 C C7B . CBS C 2 . ? 16.069 -13.184 -29.391 1.00 41.56 ? 1006 CBS A C7B 1 HETATM 3812 C C8B . CBS C 2 . ? 15.562 -12.145 -30.379 1.00 40.67 ? 1006 CBS A C8B 1 HETATM 3813 N N2B . CBS C 2 . ? 16.194 -14.486 -30.054 1.00 44.49 ? 1006 CBS A N2B 1 HETATM 3814 O O3B . CBS C 2 . ? 18.553 -15.306 -31.995 1.00 47.63 ? 1006 CBS A O3B 1 HETATM 3815 O O5B . CBS C 2 . ? 17.849 -17.542 -28.446 1.00 43.41 ? 1006 CBS A O5B 1 HETATM 3816 O O6B . CBS C 2 . ? 20.686 -18.413 -28.535 1.00 46.01 ? 1006 CBS A O6B 1 HETATM 3817 O O7B . CBS C 2 . ? 17.278 -12.749 -28.781 1.00 39.39 ? 1006 CBS A O7B 1 HETATM 3818 CU CU . CU D 3 . ? 0.076 -16.592 -22.443 1.00 39.38 ? 497 CU A CU 1 HETATM 3819 CU CU . CU E 3 . ? 1.833 -29.459 -15.795 1.00 59.48 ? 498 CU A CU 1 HETATM 3820 CU CU . CU F 3 . ? -0.222 -28.083 -18.354 1.00 37.98 ? 499 CU A CU 1 HETATM 3821 CU CU . CU G 3 . ? -0.436 -27.091 -15.333 1.00 44.27 ? 500 CU A CU 1 HETATM 3822 O O . HOH H 4 . ? -7.274 -0.432 -5.800 1.00 17.40 ? 1007 HOH A O 1 HETATM 3823 O O . HOH H 4 . ? -15.308 -24.717 -18.066 1.00 22.82 ? 1008 HOH A O 1 HETATM 3824 O O . HOH H 4 . ? 8.263 -16.404 -9.842 1.00 22.01 ? 1009 HOH A O 1 HETATM 3825 O O . HOH H 4 . ? -7.490 -41.743 -23.811 1.00 22.77 ? 1010 HOH A O 1 HETATM 3826 O O . HOH H 4 . ? 11.990 -28.326 0.904 1.00 14.24 ? 1011 HOH A O 1 HETATM 3827 O O . HOH H 4 . ? 12.776 -17.874 11.073 1.00 37.06 ? 1012 HOH A O 1 HETATM 3828 O O . HOH H 4 . ? 9.515 -5.677 -2.633 1.00 26.86 ? 1013 HOH A O 1 HETATM 3829 O O . HOH H 4 . ? -5.489 -29.342 -23.042 1.00 22.94 ? 1014 HOH A O 1 HETATM 3830 O O . HOH H 4 . ? 7.884 -40.150 -12.453 1.00 27.78 ? 1015 HOH A O 1 HETATM 3831 O O . HOH H 4 . ? -13.711 -17.773 -11.761 1.00 21.68 ? 1016 HOH A O 1 HETATM 3832 O O . HOH H 4 . ? 3.930 -33.777 -16.145 1.00 26.16 ? 1017 HOH A O 1 HETATM 3833 O O . HOH H 4 . ? 8.154 -30.438 6.383 1.00 23.27 ? 1018 HOH A O 1 HETATM 3834 O O . HOH H 4 . ? 0.782 -15.580 -14.769 1.00 24.01 ? 1019 HOH A O 1 HETATM 3835 O O . HOH H 4 . ? -15.325 -45.563 -9.039 1.00 32.25 ? 1020 HOH A O 1 HETATM 3836 O O . HOH H 4 . ? -7.025 -10.182 -11.464 1.00 28.54 ? 1021 HOH A O 1 HETATM 3837 O O . HOH H 4 . ? -4.100 -38.407 -19.295 1.00 33.19 ? 1022 HOH A O 1 HETATM 3838 O O . HOH H 4 . ? 5.917 -12.569 -25.562 1.00 29.86 ? 1023 HOH A O 1 HETATM 3839 O O . HOH H 4 . ? -0.085 -50.222 -31.953 1.00 24.89 ? 1024 HOH A O 1 HETATM 3840 O O . HOH H 4 . ? -19.613 -28.941 -15.697 1.00 24.71 ? 1025 HOH A O 1 HETATM 3841 O O . HOH H 4 . ? -23.053 -14.997 -13.042 1.00 28.20 ? 1026 HOH A O 1 HETATM 3842 O O . HOH H 4 . ? 19.468 -14.567 1.786 1.00 33.67 ? 1027 HOH A O 1 HETATM 3843 O O . HOH H 4 . ? -10.372 -50.834 -25.162 1.00 19.45 ? 1028 HOH A O 1 HETATM 3844 O O . HOH H 4 . ? -15.142 -15.715 -19.762 1.00 30.50 ? 1029 HOH A O 1 HETATM 3845 O O . HOH H 4 . ? -10.900 -25.051 -6.266 1.00 19.77 ? 1030 HOH A O 1 HETATM 3846 O O . HOH H 4 . ? 7.935 -42.107 -19.398 1.00 37.89 ? 1031 HOH A O 1 HETATM 3847 O O . HOH H 4 . ? 21.308 -22.261 -30.761 1.00 31.13 ? 1032 HOH A O 1 HETATM 3848 O O . HOH H 4 . ? -11.616 -12.793 11.404 1.00 29.54 ? 1033 HOH A O 1 HETATM 3849 O O . HOH H 4 . ? 10.431 -32.688 -35.096 1.00 19.94 ? 1034 HOH A O 1 HETATM 3850 O O . HOH H 4 . ? -14.433 -32.988 -28.175 1.00 27.17 ? 1035 HOH A O 1 HETATM 3851 O O . HOH H 4 . ? -17.650 -22.179 -18.686 1.00 34.65 ? 1036 HOH A O 1 HETATM 3852 O O . HOH H 4 . ? -7.349 -10.556 -14.251 1.00 28.15 ? 1037 HOH A O 1 HETATM 3853 O O . HOH H 4 . ? -17.649 -20.283 -1.670 1.00 45.12 ? 1038 HOH A O 1 HETATM 3854 O O . HOH H 4 . ? -1.598 -20.883 15.704 1.00 47.13 ? 1039 HOH A O 1 HETATM 3855 O O . HOH H 4 . ? 11.115 -39.114 -30.636 1.00 29.14 ? 1040 HOH A O 1 HETATM 3856 O O . HOH H 4 . ? -20.627 -42.487 -23.960 1.00 35.45 ? 1041 HOH A O 1 HETATM 3857 O O . HOH H 4 . ? -10.261 -22.032 -6.781 1.00 25.44 ? 1042 HOH A O 1 HETATM 3858 O O . HOH H 4 . ? -9.077 -21.071 -4.452 1.00 15.20 ? 1043 HOH A O 1 HETATM 3859 O O . HOH H 4 . ? -9.163 -44.117 -24.806 1.00 27.02 ? 1044 HOH A O 1 HETATM 3860 O O . HOH H 4 . ? -8.181 -50.367 -15.665 1.00 31.17 ? 1045 HOH A O 1 HETATM 3861 O O . HOH H 4 . ? 1.960 -28.562 4.197 1.00 20.57 ? 1046 HOH A O 1 HETATM 3862 O O . HOH H 4 . ? 19.121 -19.256 -11.815 1.00 21.31 ? 1047 HOH A O 1 HETATM 3863 O O . HOH H 4 . ? -24.635 -26.270 -12.477 1.00 29.38 ? 1048 HOH A O 1 HETATM 3864 O O . HOH H 4 . ? 17.940 -25.749 11.038 1.00 18.78 ? 1049 HOH A O 1 HETATM 3865 O O . HOH H 4 . ? -10.565 -46.739 -13.545 1.00 19.88 ? 1050 HOH A O 1 HETATM 3866 O O . HOH H 4 . ? -4.912 -4.925 2.591 1.00 33.85 ? 1051 HOH A O 1 HETATM 3867 O O . HOH H 4 . ? -8.511 -45.703 -26.909 1.00 34.41 ? 1052 HOH A O 1 HETATM 3868 O O . HOH H 4 . ? -17.775 -25.722 -0.148 1.00 34.21 ? 1053 HOH A O 1 HETATM 3869 O O . HOH H 4 . ? 11.165 -8.545 -18.089 1.00 22.63 ? 1054 HOH A O 1 HETATM 3870 O O . HOH H 4 . ? 7.297 -43.278 -12.293 1.00 29.81 ? 1055 HOH A O 1 HETATM 3871 O O . HOH H 4 . ? 17.774 -18.437 -14.107 1.00 25.11 ? 1056 HOH A O 1 HETATM 3872 O O . HOH H 4 . ? -8.304 -15.406 14.310 1.00 40.65 ? 1057 HOH A O 1 HETATM 3873 O O . HOH H 4 . ? -15.551 -38.865 -3.290 1.00 29.94 ? 1058 HOH A O 1 HETATM 3874 O O . HOH H 4 . ? -12.258 -5.079 12.124 1.00 33.69 ? 1059 HOH A O 1 HETATM 3875 O O . HOH H 4 . ? -14.467 -32.695 0.628 1.00 33.00 ? 1060 HOH A O 1 HETATM 3876 O O . HOH H 4 . ? -24.259 -19.141 -11.973 1.00 16.12 ? 1061 HOH A O 1 HETATM 3877 O O . HOH H 4 . ? -12.630 -47.133 -14.960 1.00 23.83 ? 1062 HOH A O 1 HETATM 3878 O O . HOH H 4 . ? -9.608 -10.237 -3.834 1.00 27.92 ? 1063 HOH A O 1 HETATM 3879 O O . HOH H 4 . ? -6.941 -19.383 5.782 1.00 20.65 ? 1064 HOH A O 1 HETATM 3880 O O . HOH H 4 . ? -17.887 -13.553 1.794 1.00 46.77 ? 1065 HOH A O 1 HETATM 3881 O O . HOH H 4 . ? 0.611 -35.048 -13.847 1.00 33.39 ? 1066 HOH A O 1 HETATM 3882 O O . HOH H 4 . ? -12.656 -44.100 -30.013 1.00 27.95 ? 1067 HOH A O 1 HETATM 3883 O O . HOH H 4 . ? -15.277 -41.985 -19.111 1.00 24.53 ? 1068 HOH A O 1 HETATM 3884 O O . HOH H 4 . ? -14.567 -18.691 -14.457 1.00 26.20 ? 1069 HOH A O 1 HETATM 3885 O O . HOH H 4 . ? -19.272 -36.018 -20.283 1.00 25.71 ? 1070 HOH A O 1 HETATM 3886 O O . HOH H 4 . ? 11.601 -15.880 -16.065 1.00 30.64 ? 1071 HOH A O 1 HETATM 3887 O O . HOH H 4 . ? 0.700 -49.759 -28.972 1.00 26.45 ? 1072 HOH A O 1 HETATM 3888 O O . HOH H 4 . ? -7.786 -39.942 1.174 1.00 33.88 ? 1073 HOH A O 1 HETATM 3889 O O . HOH H 4 . ? 9.662 -17.032 -13.768 1.00 18.28 ? 1074 HOH A O 1 HETATM 3890 O O . HOH H 4 . ? -19.754 -41.373 -12.266 1.00 30.22 ? 1075 HOH A O 1 HETATM 3891 O O . HOH H 4 . ? 14.143 -30.839 -5.200 1.00 35.80 ? 1076 HOH A O 1 HETATM 3892 O O . HOH H 4 . ? -9.542 -19.041 5.959 1.00 34.82 ? 1077 HOH A O 1 HETATM 3893 O O . HOH H 4 . ? -18.987 -3.638 -1.356 1.00 40.86 ? 1078 HOH A O 1 HETATM 3894 O O . HOH H 4 . ? 15.447 -36.706 -0.170 1.00 26.68 ? 1079 HOH A O 1 HETATM 3895 O O . HOH H 4 . ? 10.329 -14.092 -13.901 1.00 22.74 ? 1080 HOH A O 1 HETATM 3896 O O . HOH H 4 . ? -17.683 -7.832 -13.525 1.00 37.12 ? 1081 HOH A O 1 HETATM 3897 O O . HOH H 4 . ? -4.168 -48.728 -12.765 1.00 37.07 ? 1082 HOH A O 1 HETATM 3898 O O . HOH H 4 . ? 33.577 -21.752 -10.183 1.00 51.01 ? 1083 HOH A O 1 HETATM 3899 O O . HOH H 4 . ? 9.120 -15.986 -29.731 1.00 31.24 ? 1084 HOH A O 1 HETATM 3900 O O . HOH H 4 . ? 11.701 -31.932 -5.291 1.00 30.87 ? 1085 HOH A O 1 HETATM 3901 O O . HOH H 4 . ? -6.358 -11.948 -9.488 1.00 24.07 ? 1086 HOH A O 1 HETATM 3902 O O . HOH H 4 . ? 5.062 -39.088 -11.439 1.00 30.36 ? 1087 HOH A O 1 HETATM 3903 O O . HOH H 4 . ? 16.939 -9.404 -21.200 1.00 35.32 ? 1088 HOH A O 1 HETATM 3904 O O . HOH H 4 . ? 1.562 -33.909 -21.530 1.00 35.43 ? 1089 HOH A O 1 HETATM 3905 O O . HOH H 4 . ? -20.944 -26.601 -0.989 1.00 28.76 ? 1090 HOH A O 1 HETATM 3906 O O . HOH H 4 . ? 16.079 -18.223 -34.382 1.00 36.79 ? 1091 HOH A O 1 HETATM 3907 O O . HOH H 4 . ? -8.142 -25.450 -4.217 1.00 33.03 ? 1092 HOH A O 1 HETATM 3908 O O . HOH H 4 . ? 8.062 -11.518 -16.195 1.00 28.15 ? 1093 HOH A O 1 HETATM 3909 O O . HOH H 4 . ? -15.537 -13.549 -16.848 1.00 48.44 ? 1094 HOH A O 1 HETATM 3910 O O . HOH H 4 . ? 1.382 -48.876 -24.002 1.00 20.65 ? 1095 HOH A O 1 HETATM 3911 O O . HOH H 4 . ? 6.441 -5.827 15.069 1.00 42.97 ? 1096 HOH A O 1 HETATM 3912 O O . HOH H 4 . ? 12.317 -19.815 -34.507 1.00 35.15 ? 1097 HOH A O 1 HETATM 3913 O O . HOH H 4 . ? 12.650 -10.623 -26.768 1.00 34.61 ? 1098 HOH A O 1 HETATM 3914 O O . HOH H 4 . ? 13.402 -10.750 12.983 1.00 29.34 ? 1099 HOH A O 1 HETATM 3915 O O . HOH H 4 . ? 6.195 -13.495 -22.774 1.00 29.15 ? 1100 HOH A O 1 HETATM 3916 O O . HOH H 4 . ? -8.040 -34.530 -35.395 1.00 37.08 ? 1101 HOH A O 1 HETATM 3917 O O . HOH H 4 . ? 12.657 -34.119 -6.248 1.00 32.28 ? 1102 HOH A O 1 HETATM 3918 O O . HOH H 4 . ? 9.755 -36.838 -37.283 1.00 45.21 ? 1103 HOH A O 1 HETATM 3919 O O . HOH H 4 . ? -3.476 -10.861 -16.546 1.00 21.79 ? 1104 HOH A O 1 HETATM 3920 O O . HOH H 4 . ? -9.119 -8.714 -10.036 1.00 31.28 ? 1105 HOH A O 1 HETATM 3921 O O . HOH H 4 . ? 6.314 -30.480 -15.192 1.00 42.46 ? 1106 HOH A O 1 HETATM 3922 O O . HOH H 4 . ? 7.803 -38.851 -9.947 1.00 35.69 ? 1107 HOH A O 1 HETATM 3923 O O . HOH H 4 . ? -13.063 -20.050 -22.229 1.00 29.72 ? 1108 HOH A O 1 HETATM 3924 O O . HOH H 4 . ? 13.045 -33.615 -3.561 1.00 30.21 ? 1109 HOH A O 1 HETATM 3925 O O . HOH H 4 . ? -12.418 -34.685 0.325 1.00 28.33 ? 1110 HOH A O 1 HETATM 3926 O O . HOH H 4 . ? 22.093 -32.476 -8.315 1.00 33.85 ? 1111 HOH A O 1 HETATM 3927 O O . HOH H 4 . ? 21.552 -19.562 -10.166 1.00 24.03 ? 1112 HOH A O 1 HETATM 3928 O O . HOH H 4 . ? -8.977 -13.457 1.756 1.00 38.77 ? 1113 HOH A O 1 HETATM 3929 O O . HOH H 4 . ? -4.231 -1.100 6.133 1.00 33.98 ? 1114 HOH A O 1 HETATM 3930 O O . HOH H 4 . ? -25.483 -12.182 -17.522 1.00 41.96 ? 1115 HOH A O 1 HETATM 3931 O O . HOH H 4 . ? -8.529 -25.820 -18.042 1.00 22.46 ? 1116 HOH A O 1 HETATM 3932 O O . HOH H 4 . ? 2.471 -7.567 -2.658 1.00 28.68 ? 1117 HOH A O 1 HETATM 3933 O O . HOH H 4 . ? -20.989 -43.130 -21.356 1.00 28.65 ? 1118 HOH A O 1 HETATM 3934 O O . HOH H 4 . ? -23.907 -9.712 -16.714 1.00 33.97 ? 1119 HOH A O 1 HETATM 3935 O O . HOH H 4 . ? -21.885 -32.261 -5.234 1.00 24.58 ? 1120 HOH A O 1 HETATM 3936 O O . HOH H 4 . ? 6.033 -46.513 -28.967 1.00 27.83 ? 1121 HOH A O 1 HETATM 3937 O O . HOH H 4 . ? -4.747 -6.542 18.193 1.00 36.85 ? 1122 HOH A O 1 HETATM 3938 O O . HOH H 4 . ? 0.159 -6.999 -27.797 1.00 21.92 ? 1123 HOH A O 1 HETATM 3939 O O . HOH H 4 . ? 8.218 -48.185 -17.400 1.00 38.68 ? 1124 HOH A O 1 HETATM 3940 O O . HOH H 4 . ? -9.567 -9.643 -0.894 1.00 28.57 ? 1125 HOH A O 1 HETATM 3941 O O . HOH H 4 . ? -10.862 -32.948 2.381 1.00 26.49 ? 1126 HOH A O 1 HETATM 3942 O O . HOH H 4 . ? 7.032 -5.615 0.055 1.00 26.39 ? 1127 HOH A O 1 HETATM 3943 O O . HOH H 4 . ? 6.734 -5.566 2.723 1.00 27.14 ? 1128 HOH A O 1 HETATM 3944 O O . HOH H 4 . ? -31.757 -18.558 -18.364 1.00 32.85 ? 1129 HOH A O 1 HETATM 3945 O O . HOH H 4 . ? -5.984 -26.287 -18.838 1.00 20.23 ? 1130 HOH A O 1 HETATM 3946 O O . HOH H 4 . ? -28.689 -21.272 -16.932 1.00 22.48 ? 1131 HOH A O 1 HETATM 3947 O O . HOH H 4 . ? -13.808 -27.057 -6.136 1.00 24.61 ? 1132 HOH A O 1 HETATM 3948 O O . HOH H 4 . ? 22.304 -15.765 -27.577 1.00 40.61 ? 1133 HOH A O 1 HETATM 3949 O O . HOH H 4 . ? -6.934 -45.369 -32.835 1.00 33.02 ? 1134 HOH A O 1 HETATM 3950 O O . HOH H 4 . ? -21.638 -36.197 -6.449 1.00 36.50 ? 1135 HOH A O 1 HETATM 3951 O O . HOH H 4 . ? 9.133 -13.836 18.682 1.00 52.76 ? 1136 HOH A O 1 HETATM 3952 O O . HOH H 4 . ? -14.118 -9.374 -18.644 1.00 32.24 ? 1137 HOH A O 1 HETATM 3953 O O . HOH H 4 . ? -15.350 -14.480 1.037 1.00 37.75 ? 1138 HOH A O 1 HETATM 3954 O O . HOH H 4 . ? -1.146 -34.875 5.177 1.00 22.20 ? 1139 HOH A O 1 HETATM 3955 O O . HOH H 4 . ? 1.620 -13.382 -16.600 1.00 20.09 ? 1140 HOH A O 1 HETATM 3956 O O . HOH H 4 . ? -11.724 -34.966 4.439 1.00 37.23 ? 1141 HOH A O 1 HETATM 3957 O O . HOH H 4 . ? -13.037 -49.421 -18.607 1.00 30.52 ? 1142 HOH A O 1 HETATM 3958 O O . HOH H 4 . ? -14.519 -41.239 -21.552 1.00 30.16 ? 1143 HOH A O 1 HETATM 3959 O O . HOH H 4 . ? -13.144 -34.442 -29.739 1.00 28.91 ? 1144 HOH A O 1 HETATM 3960 O O . HOH H 4 . ? -7.237 -19.381 -3.464 1.00 31.91 ? 1145 HOH A O 1 HETATM 3961 O O . HOH H 4 . ? 21.495 -25.265 -9.983 1.00 29.57 ? 1146 HOH A O 1 HETATM 3962 O O . HOH H 4 . ? 4.558 -43.197 -12.212 1.00 25.29 ? 1147 HOH A O 1 HETATM 3963 O O . HOH H 4 . ? 7.159 -37.835 5.586 1.00 51.35 ? 1148 HOH A O 1 HETATM 3964 O O . HOH H 4 . ? 10.851 -7.291 5.891 1.00 36.38 ? 1149 HOH A O 1 HETATM 3965 O O . HOH H 4 . ? 6.986 -2.412 -4.050 1.00 38.31 ? 1150 HOH A O 1 HETATM 3966 O O . HOH H 4 . ? 2.240 -45.600 -1.426 1.00 42.19 ? 1151 HOH A O 1 HETATM 3967 O O . HOH H 4 . ? -30.886 -12.567 -18.073 1.00 37.27 ? 1152 HOH A O 1 HETATM 3968 O O . HOH H 4 . ? 13.435 -36.235 -17.032 1.00 46.90 ? 1153 HOH A O 1 HETATM 3969 O O . HOH H 4 . ? -0.842 -12.621 -16.885 1.00 31.10 ? 1154 HOH A O 1 HETATM 3970 O O . HOH H 4 . ? -13.974 -43.775 -17.620 1.00 29.98 ? 1155 HOH A O 1 HETATM 3971 O O . HOH H 4 . ? 10.653 -14.444 -31.788 1.00 25.12 ? 1156 HOH A O 1 HETATM 3972 O O . HOH H 4 . ? 24.602 -36.295 -24.169 1.00 44.87 ? 1157 HOH A O 1 HETATM 3973 O O . HOH H 4 . ? -10.707 -33.384 -30.137 1.00 29.24 ? 1158 HOH A O 1 HETATM 3974 O O . HOH H 4 . ? 3.880 -29.629 11.345 1.00 42.89 ? 1159 HOH A O 1 HETATM 3975 O O . HOH H 4 . ? 10.208 -31.790 17.540 1.00 52.59 ? 1160 HOH A O 1 HETATM 3976 O O . HOH H 4 . ? -21.751 -38.294 -4.484 1.00 33.91 ? 1161 HOH A O 1 HETATM 3977 O O . HOH H 4 . ? 14.805 -41.618 -29.865 1.00 36.93 ? 1162 HOH A O 1 HETATM 3978 O O . HOH H 4 . ? 1.981 -47.394 -16.965 1.00 36.95 ? 1163 HOH A O 1 HETATM 3979 O O . HOH H 4 . ? -15.783 -11.433 -19.151 1.00 23.02 ? 1164 HOH A O 1 HETATM 3980 O O . HOH H 4 . ? 4.367 -45.855 -11.666 1.00 30.43 ? 1165 HOH A O 1 HETATM 3981 O O . HOH H 4 . ? -13.313 -17.573 -16.162 1.00 30.18 ? 1166 HOH A O 1 HETATM 3982 O O . HOH H 4 . ? 8.336 -9.357 -17.650 1.00 40.05 ? 1167 HOH A O 1 HETATM 3983 O O . HOH H 4 . ? -12.761 -45.624 -18.984 1.00 35.14 ? 1168 HOH A O 1 HETATM 3984 O O . HOH H 4 . ? -3.784 -29.581 9.643 1.00 40.96 ? 1169 HOH A O 1 HETATM 3985 O O . HOH H 4 . ? 12.703 -15.663 -32.658 1.00 31.09 ? 1170 HOH A O 1 HETATM 3986 O O . HOH H 4 . ? -11.101 -28.306 1.756 1.00 30.17 ? 1171 HOH A O 1 HETATM 3987 O O . HOH H 4 . ? -8.598 -48.372 -13.645 1.00 28.61 ? 1172 HOH A O 1 HETATM 3988 O O . HOH H 4 . ? 10.094 -11.517 -14.740 1.00 31.81 ? 1173 HOH A O 1 HETATM 3989 O O . HOH H 4 . ? -18.150 -22.478 -0.969 1.00 37.17 ? 1174 HOH A O 1 HETATM 3990 O O . HOH H 4 . ? -0.472 -45.654 -1.512 1.00 39.29 ? 1175 HOH A O 1 HETATM 3991 O O . HOH H 4 . ? 12.804 -44.900 -19.581 1.00 44.38 ? 1176 HOH A O 1 HETATM 3992 O O . HOH H 4 . ? 10.294 -28.743 16.037 1.00 37.91 ? 1177 HOH A O 1 HETATM 3993 O O . HOH H 4 . ? 12.923 -32.849 -1.059 1.00 28.99 ? 1178 HOH A O 1 HETATM 3994 O O . HOH H 4 . ? 18.661 -30.015 -8.616 1.00 27.46 ? 1179 HOH A O 1 HETATM 3995 O O . HOH H 4 . ? -6.954 -36.889 -34.480 1.00 38.19 ? 1180 HOH A O 1 HETATM 3996 O O . HOH H 4 . ? 20.158 -22.562 -28.504 1.00 35.57 ? 1181 HOH A O 1 HETATM 3997 O O . HOH H 4 . ? 16.979 -31.060 -9.876 1.00 32.72 ? 1182 HOH A O 1 HETATM 3998 O O . HOH H 4 . ? 18.077 -29.312 -5.596 1.00 37.16 ? 1183 HOH A O 1 HETATM 3999 O O . HOH H 4 . ? 19.262 -14.685 -16.298 1.00 36.60 ? 1184 HOH A O 1 HETATM 4000 O O . HOH H 4 . ? -1.178 -27.273 -35.587 1.00 30.84 ? 1185 HOH A O 1 HETATM 4001 O O . HOH H 4 . ? -16.649 -45.678 -14.917 1.00 38.59 ? 1186 HOH A O 1 HETATM 4002 O O . HOH H 4 . ? 1.099 -37.100 4.721 1.00 38.25 ? 1187 HOH A O 1 HETATM 4003 O O . HOH H 4 . ? 22.952 -26.316 -31.187 1.00 34.50 ? 1188 HOH A O 1 HETATM 4004 O O . HOH H 4 . ? 16.995 -28.123 7.800 1.00 46.30 ? 1189 HOH A O 1 HETATM 4005 O O . HOH H 4 . ? 27.499 -20.179 -15.684 1.00 37.08 ? 1190 HOH A O 1 HETATM 4006 O O . HOH H 4 . ? -24.025 -38.228 -14.989 1.00 32.83 ? 1191 HOH A O 1 HETATM 4007 O O . HOH H 4 . ? 6.884 -9.802 2.587 1.00 22.18 ? 1192 HOH A O 1 HETATM 4008 O O . HOH H 4 . ? -9.325 -17.360 13.386 1.00 34.28 ? 1193 HOH A O 1 HETATM 4009 O O . HOH H 4 . ? -7.697 -22.794 -2.714 1.00 28.63 ? 1194 HOH A O 1 HETATM 4010 O O . HOH H 4 . ? -12.358 -37.075 -29.379 1.00 34.34 ? 1195 HOH A O 1 HETATM 4011 O O . HOH H 4 . ? -7.798 -23.661 -0.368 1.00 26.74 ? 1196 HOH A O 1 HETATM 4012 O O . HOH H 4 . ? 23.536 -19.819 -37.114 1.00 34.86 ? 1197 HOH A O 1 HETATM 4013 O O . HOH H 4 . ? 13.779 -6.783 2.628 1.00 37.18 ? 1198 HOH A O 1 HETATM 4014 O O . HOH H 4 . ? 23.463 -17.461 -6.387 1.00 25.90 ? 1199 HOH A O 1 HETATM 4015 O O . HOH H 4 . ? -8.315 -28.357 1.839 1.00 33.89 ? 1200 HOH A O 1 HETATM 4016 O O . HOH H 4 . ? 19.227 -17.886 -25.927 1.00 35.33 ? 1201 HOH A O 1 HETATM 4017 O O . HOH H 4 . ? 19.696 -31.890 -14.669 1.00 32.41 ? 1202 HOH A O 1 HETATM 4018 O O . HOH H 4 . ? 25.366 -31.862 -25.341 1.00 33.07 ? 1203 HOH A O 1 HETATM 4019 O O . HOH H 4 . ? -6.233 -47.097 -14.020 1.00 28.68 ? 1204 HOH A O 1 HETATM 4020 O O . HOH H 4 . ? -0.677 -26.287 12.803 1.00 28.98 ? 1205 HOH A O 1 HETATM 4021 O O . HOH H 4 . ? 17.928 -12.092 -4.435 1.00 29.10 ? 1206 HOH A O 1 HETATM 4022 O O . HOH H 4 . ? -27.298 -31.809 -23.873 1.00 44.47 ? 1207 HOH A O 1 HETATM 4023 O O . HOH H 4 . ? -26.167 -27.871 -12.985 1.00 41.26 ? 1208 HOH A O 1 HETATM 4024 O O . HOH H 4 . ? 6.981 -7.951 -15.139 1.00 39.36 ? 1209 HOH A O 1 HETATM 4025 O O . HOH H 4 . ? 18.125 -33.140 -5.481 1.00 36.18 ? 1210 HOH A O 1 HETATM 4026 O O . HOH H 4 . ? -19.727 -22.433 1.541 1.00 37.70 ? 1211 HOH A O 1 HETATM 4027 O O . HOH H 4 . ? 5.171 -25.496 -33.806 1.00 30.06 ? 1212 HOH A O 1 HETATM 4028 O O . HOH H 4 . ? -14.241 -24.270 -20.436 1.00 33.70 ? 1213 HOH A O 1 HETATM 4029 O O . HOH H 4 . ? 11.964 -36.717 -15.464 1.00 37.11 ? 1214 HOH A O 1 HETATM 4030 O O . HOH H 4 . ? 25.741 -34.292 -26.272 1.00 37.65 ? 1215 HOH A O 1 HETATM 4031 O O . HOH H 4 . ? -3.972 0.524 -2.843 1.00 41.20 ? 1216 HOH A O 1 HETATM 4032 O O . HOH H 4 . ? -0.170 -30.391 12.844 1.00 35.69 ? 1217 HOH A O 1 HETATM 4033 O O . HOH H 4 . ? 12.710 -23.938 13.939 1.00 23.64 ? 1218 HOH A O 1 HETATM 4034 O O . HOH H 4 . ? 12.266 -39.336 -15.651 1.00 48.83 ? 1219 HOH A O 1 HETATM 4035 O O . HOH H 4 . ? 7.180 -20.262 -39.311 1.00 44.47 ? 1220 HOH A O 1 HETATM 4036 O O . HOH H 4 . ? 23.592 -17.402 -8.941 1.00 38.96 ? 1221 HOH A O 1 HETATM 4037 O O . HOH H 4 . ? -26.101 -34.621 -17.561 1.00 41.37 ? 1222 HOH A O 1 HETATM 4038 O O . HOH H 4 . ? 3.819 -8.285 -14.807 1.00 37.77 ? 1223 HOH A O 1 HETATM 4039 O O . HOH H 4 . ? 16.841 -23.047 -35.913 1.00 45.52 ? 1224 HOH A O 1 HETATM 4040 O O . HOH H 4 . ? -18.850 -9.807 -15.215 1.00 39.09 ? 1225 HOH A O 1 HETATM 4041 O O . HOH H 4 . ? -23.527 -43.244 -29.163 1.00 42.63 ? 1226 HOH A O 1 HETATM 4042 O O . HOH H 4 . ? -14.658 -14.367 9.104 1.00 28.97 ? 1227 HOH A O 1 HETATM 4043 O O . HOH H 4 . ? 0.132 -0.286 1.826 1.00 48.13 ? 1228 HOH A O 1 HETATM 4044 O O . HOH H 4 . ? -24.531 -38.347 -25.258 1.00 42.44 ? 1229 HOH A O 1 HETATM 4045 O O . HOH H 4 . ? -12.363 -14.918 8.482 1.00 35.72 ? 1230 HOH A O 1 HETATM 4046 O O . HOH H 4 . ? -12.106 -21.265 1.847 1.00 40.57 ? 1231 HOH A O 1 HETATM 4047 O O . HOH H 4 . ? -28.256 -12.331 -17.365 1.00 51.07 ? 1232 HOH A O 1 HETATM 4048 O O . HOH H 4 . ? 24.810 -24.771 -4.179 1.00 49.21 ? 1233 HOH A O 1 HETATM 4049 O O . HOH H 4 . ? 11.789 -14.644 -23.450 1.00 36.20 ? 1234 HOH A O 1 HETATM 4050 O O . HOH H 4 . ? 31.185 -25.148 -11.606 1.00 50.05 ? 1235 HOH A O 1 HETATM 4051 O O . HOH H 4 . ? -10.291 -44.536 -2.399 1.00 37.64 ? 1236 HOH A O 1 HETATM 4052 O O . HOH H 4 . ? -12.030 -5.555 -12.494 1.00 37.25 ? 1237 HOH A O 1 HETATM 4053 O O . HOH H 4 . ? 25.324 -19.225 -35.943 1.00 42.99 ? 1238 HOH A O 1 HETATM 4054 O O . HOH H 4 . ? -14.369 -21.589 1.247 1.00 39.33 ? 1239 HOH A O 1 HETATM 4055 O O . HOH H 4 . ? 17.515 -34.152 15.094 1.00 49.82 ? 1240 HOH A O 1 HETATM 4056 O O . HOH H 4 . ? -6.667 -29.333 -24.926 1.00 27.96 ? 1241 HOH A O 1 HETATM 4057 O O . HOH H 4 . ? -8.362 -16.616 -35.591 1.00 38.45 ? 1242 HOH A O 1 HETATM 4058 O O . HOH H 4 . ? -9.364 -45.222 -4.481 1.00 32.30 ? 1243 HOH A O 1 HETATM 4059 O O . HOH H 4 . ? -26.739 -26.466 -18.160 1.00 34.99 ? 1244 HOH A O 1 HETATM 4060 O O . HOH H 4 . ? 4.499 -18.341 -34.763 1.00 44.56 ? 1245 HOH A O 1 HETATM 4061 O O . HOH H 4 . ? -25.508 -18.462 -20.082 1.00 62.46 ? 1246 HOH A O 1 HETATM 4062 O O . HOH H 4 . ? 3.660 -2.817 8.871 1.00 43.61 ? 1247 HOH A O 1 HETATM 4063 O O . HOH H 4 . ? 16.343 -35.155 12.478 1.00 41.34 ? 1248 HOH A O 1 HETATM 4064 O O . HOH H 4 . ? -15.622 -16.571 5.169 1.00 34.08 ? 1249 HOH A O 1 HETATM 4065 O O . HOH H 4 . ? -25.484 -20.980 -19.901 1.00 41.62 ? 1250 HOH A O 1 HETATM 4066 O O . HOH H 4 . ? 9.673 -11.092 -7.437 1.00 34.19 ? 1251 HOH A O 1 HETATM 4067 O O . HOH H 4 . ? 2.767 -12.848 -35.347 1.00 44.19 ? 1252 HOH A O 1 HETATM 4068 O O . HOH H 4 . ? -9.910 -35.080 -1.184 1.00 47.62 ? 1253 HOH A O 1 HETATM 4069 O O . HOH H 4 . ? 2.828 -48.171 -36.957 1.00 61.99 ? 1254 HOH A O 1 HETATM 4070 O O . HOH H 4 . ? -6.929 -27.580 -20.954 1.00 44.10 ? 1255 HOH A O 1 HETATM 4071 O O . HOH H 4 . ? -10.035 -45.254 -29.136 1.00 45.17 ? 1256 HOH A O 1 HETATM 4072 O O . HOH H 4 . ? -1.669 -49.121 -14.369 1.00 42.09 ? 1257 HOH A O 1 HETATM 4073 O O . HOH H 4 . ? -3.340 -35.353 6.125 1.00 43.99 ? 1258 HOH A O 1 HETATM 4074 O O . HOH H 4 . ? 13.415 -41.097 -32.198 1.00 43.25 ? 1259 HOH A O 1 HETATM 4075 O O . HOH H 4 . ? -13.254 -36.971 1.142 1.00 52.62 ? 1260 HOH A O 1 HETATM 4076 O O . HOH H 4 . ? -8.362 -18.409 11.053 1.00 81.07 ? 1261 HOH A O 1 # loop_ _pdbx_poly_seq_scheme.asym_id _pdbx_poly_seq_scheme.entity_id _pdbx_poly_seq_scheme.seq_id _pdbx_poly_seq_scheme.mon_id _pdbx_poly_seq_scheme.ndb_seq_num _pdbx_poly_seq_scheme.pdb_seq_num _pdbx_poly_seq_scheme.auth_seq_num _pdbx_poly_seq_scheme.pdb_mon_id _pdbx_poly_seq_scheme.auth_mon_id _pdbx_poly_seq_scheme.pdb_strand_id _pdbx_poly_seq_scheme.pdb_ins_code _pdbx_poly_seq_scheme.hetero A 1 1 ALA 1 1 1 ALA ALA A . n A 1 2 ILE 2 2 2 ILE ILE A . n A 1 3 GLY 3 3 3 GLY GLY A . n A 1 4 PRO 4 4 4 PRO PRO A . n A 1 5 VAL 5 5 5 VAL VAL A . n A 1 6 ALA 6 6 6 ALA ALA A . n A 1 7 ASP 7 7 7 ASP ASP A . n A 1 8 LEU 8 8 8 LEU LEU A . n A 1 9 THR 9 9 9 THR THR A . n A 1 10 ILE 10 10 10 ILE ILE A . n A 1 11 SER 11 11 11 SER SER A . n A 1 12 ASN 12 12 12 ASN ASN A . n A 1 13 GLY 13 13 13 GLY GLY A . n A 1 14 ALA 14 14 14 ALA ALA A . n A 1 15 VAL 15 15 15 VAL VAL A . n A 1 16 SER 16 16 16 SER SER A . n A 1 17 PRO 17 17 17 PRO PRO A . n A 1 18 ASP 18 18 18 ASP ASP A . n A 1 19 GLY 19 19 19 GLY GLY A . n A 1 20 PHE 20 20 20 PHE PHE A . n A 1 21 SER 21 21 21 SER SER A . n A 1 22 ARG 22 22 22 ARG ARG A . n A 1 23 GLN 23 23 23 GLN GLN A . n A 1 24 ALA 24 24 24 ALA ALA A . n A 1 25 ILE 25 25 25 ILE ILE A . n A 1 26 LEU 26 26 26 LEU LEU A . n A 1 27 VAL 27 27 27 VAL VAL A . n A 1 28 ASN 28 28 28 ASN ASN A . n A 1 29 ASP 29 29 29 ASP ASP A . n A 1 30 VAL 30 30 30 VAL VAL A . n A 1 31 PHE 31 31 31 PHE PHE A . n A 1 32 PRO 32 32 32 PRO PRO A . n A 1 33 SER 33 33 33 SER SER A . n A 1 34 PRO 34 34 34 PRO PRO A . n A 1 35 LEU 35 35 35 LEU LEU A . n A 1 36 ILE 36 36 36 ILE ILE A . n A 1 37 THR 37 37 37 THR THR A . n A 1 38 GLY 38 38 38 GLY GLY A . n A 1 39 ASN 39 39 39 ASN ASN A . n A 1 40 LYS 40 40 40 LYS LYS A . n A 1 41 GLY 41 41 41 GLY GLY A . n A 1 42 ASP 42 42 42 ASP ASP A . n A 1 43 ARG 43 43 43 ARG ARG A . n A 1 44 PHE 44 44 44 PHE PHE A . n A 1 45 GLN 45 45 45 GLN GLN A . n A 1 46 LEU 46 46 46 LEU LEU A . n A 1 47 ASN 47 47 47 ASN ASN A . n A 1 48 VAL 48 48 48 VAL VAL A . n A 1 49 ILE 49 49 49 ILE ILE A . n A 1 50 ASP 50 50 50 ASP ASP A . n A 1 51 ASN 51 51 51 ASN ASN A . n A 1 52 MET 52 52 52 MET MET A . n A 1 53 THR 53 53 53 THR THR A . n A 1 54 ASN 54 54 54 ASN ASN A . n A 1 55 HIS 55 55 55 HIS HIS A . n A 1 56 THR 56 56 56 THR THR A . n A 1 57 MET 57 57 57 MET MET A . n A 1 58 LEU 58 58 58 LEU LEU A . n A 1 59 LYS 59 59 59 LYS LYS A . n A 1 60 SER 60 60 60 SER SER A . n A 1 61 THR 61 61 61 THR THR A . n A 1 62 SER 62 62 62 SER SER A . n A 1 63 ILE 63 63 63 ILE ILE A . n A 1 64 HIS 64 64 64 HIS HIS A . n A 1 65 TRP 65 65 65 TRP TRP A . n A 1 66 HIS 66 66 66 HIS HIS A . n A 1 67 GLY 67 67 67 GLY GLY A . n A 1 68 PHE 68 68 68 PHE PHE A . n A 1 69 PHE 69 69 69 PHE PHE A . n A 1 70 GLN 70 70 70 GLN GLN A . n A 1 71 HIS 71 71 71 HIS HIS A . n A 1 72 GLY 72 72 72 GLY GLY A . n A 1 73 THR 73 73 73 THR THR A . n A 1 74 ASN 74 74 74 ASN ASN A . n A 1 75 TRP 75 75 75 TRP TRP A . n A 1 76 ALA 76 76 76 ALA ALA A . n A 1 77 ASP 77 77 77 ASP ASP A . n A 1 78 GLY 78 78 78 GLY GLY A . n A 1 79 PRO 79 79 79 PRO PRO A . n A 1 80 ALA 80 80 80 ALA ALA A . n A 1 81 PHE 81 81 81 PHE PHE A . n A 1 82 VAL 82 82 82 VAL VAL A . n A 1 83 ASN 83 83 83 ASN ASN A . n A 1 84 GLN 84 84 84 GLN GLN A . n A 1 85 CYS 85 85 85 CYS CYS A . n A 1 86 PRO 86 86 86 PRO PRO A . n A 1 87 ILE 87 87 87 ILE ILE A . n A 1 88 SER 88 88 88 SER SER A . n A 1 89 THR 89 89 89 THR THR A . n A 1 90 GLY 90 90 90 GLY GLY A . n A 1 91 HIS 91 91 91 HIS HIS A . n A 1 92 ALA 92 92 92 ALA ALA A . n A 1 93 PHE 93 93 93 PHE PHE A . n A 1 94 LEU 94 94 94 LEU LEU A . n A 1 95 TYR 95 95 95 TYR TYR A . n A 1 96 ASP 96 96 96 ASP ASP A . n A 1 97 PHE 97 97 97 PHE PHE A . n A 1 98 GLN 98 98 98 GLN GLN A . n A 1 99 VAL 99 99 99 VAL VAL A . n A 1 100 PRO 100 100 100 PRO PRO A . n A 1 101 ASP 101 101 101 ASP ASP A . n A 1 102 GLN 102 102 102 GLN GLN A . n A 1 103 ALA 103 103 103 ALA ALA A . n A 1 104 GLY 104 104 104 GLY GLY A . n A 1 105 THR 105 105 105 THR THR A . n A 1 106 PHE 106 106 106 PHE PHE A . n A 1 107 TRP 107 107 107 TRP TRP A . n A 1 108 TYR 108 108 108 TYR TYR A . n A 1 109 HIS 109 109 109 HIS HIS A . n A 1 110 SER 110 110 110 SER SER A . n A 1 111 HIS 111 111 111 HIS HIS A . n A 1 112 LEU 112 112 112 LEU LEU A . n A 1 113 SER 113 113 113 SER SER A . n A 1 114 THR 114 114 114 THR THR A . n A 1 115 GLN 115 115 115 GLN GLN A . n A 1 116 TYR 116 116 116 TYR TYR A . n A 1 117 CYS 117 117 117 CYS CYS A . n A 1 118 ASP 118 118 118 ASP ASP A . n A 1 119 GLY 119 119 119 GLY GLY A . n A 1 120 LEU 120 120 120 LEU LEU A . n A 1 121 ARG 121 121 121 ARG ARG A . n A 1 122 GLY 122 122 122 GLY GLY A . n A 1 123 PRO 123 123 123 PRO PRO A . n A 1 124 ILE 124 124 124 ILE ILE A . n A 1 125 VAL 125 125 125 VAL VAL A . n A 1 126 VAL 126 126 126 VAL VAL A . n A 1 127 TYR 127 127 127 TYR TYR A . n A 1 128 ASP 128 128 128 ASP ASP A . n A 1 129 PRO 129 129 129 PRO PRO A . n A 1 130 GLN 130 130 130 GLN GLN A . n A 1 131 ASP 131 131 131 ASP ASP A . n A 1 132 PRO 132 132 132 PRO PRO A . n A 1 133 HIS 133 133 133 HIS HIS A . n A 1 134 LYS 134 134 134 LYS LYS A . n A 1 135 SER 135 135 135 SER SER A . n A 1 136 LEU 136 136 136 LEU LEU A . n A 1 137 TYR 137 137 137 TYR TYR A . n A 1 138 ASP 138 138 138 ASP ASP A . n A 1 139 VAL 139 139 139 VAL VAL A . n A 1 140 ASP 140 140 140 ASP ASP A . n A 1 141 ASP 141 141 141 ASP ASP A . n A 1 142 ASP 142 142 142 ASP ASP A . n A 1 143 SER 143 143 143 SER SER A . n A 1 144 THR 144 144 144 THR THR A . n A 1 145 VAL 145 145 145 VAL VAL A . n A 1 146 ILE 146 146 146 ILE ILE A . n A 1 147 THR 147 147 147 THR THR A . n A 1 148 LEU 148 148 148 LEU LEU A . n A 1 149 ALA 149 149 149 ALA ALA A . n A 1 150 ASP 150 150 150 ASP ASP A . n A 1 151 TRP 151 151 151 TRP TRP A . n A 1 152 TYR 152 152 152 TYR TYR A . n A 1 153 HIS 153 153 153 HIS HIS A . n A 1 154 LEU 154 154 154 LEU LEU A . n A 1 155 ALA 155 155 155 ALA ALA A . n A 1 156 ALA 156 156 156 ALA ALA A . n A 1 157 LYS 157 157 157 LYS LYS A . n A 1 158 VAL 158 158 158 VAL VAL A . n A 1 159 GLY 159 159 159 GLY GLY A . n A 1 160 SER 160 160 160 SER SER A . n A 1 161 PRO 161 161 161 PRO PRO A . n A 1 162 VAL 162 162 162 VAL VAL A . n A 1 163 PRO 163 163 163 PRO PRO A . n A 1 164 THR 164 164 164 THR THR A . n A 1 165 ALA 165 165 165 ALA ALA A . n A 1 166 ASP 166 166 166 ASP ASP A . n A 1 167 ALA 167 167 167 ALA ALA A . n A 1 168 THR 168 168 168 THR THR A . n A 1 169 LEU 169 169 169 LEU LEU A . n A 1 170 ILE 170 170 170 ILE ILE A . n A 1 171 ASN 171 171 171 ASN ASN A . n A 1 172 GLY 172 172 172 GLY GLY A . n A 1 173 LEU 173 173 173 LEU LEU A . n A 1 174 GLY 174 174 174 GLY GLY A . n A 1 175 ARG 175 175 175 ARG ARG A . n A 1 176 SER 176 176 176 SER SER A . n A 1 177 ILE 177 177 177 ILE ILE A . n A 1 178 ASP 178 178 178 ASP ASP A . n A 1 179 THR 179 179 179 THR THR A . n A 1 180 LEU 180 180 180 LEU LEU A . n A 1 181 ASN 181 181 181 ASN ASN A . n A 1 182 ALA 182 182 182 ALA ALA A . n A 1 183 ASP 183 183 183 ASP ASP A . n A 1 184 LEU 184 184 184 LEU LEU A . n A 1 185 ALA 185 185 185 ALA ALA A . n A 1 186 VAL 186 186 186 VAL VAL A . n A 1 187 ILE 187 187 187 ILE ILE A . n A 1 188 THR 188 188 188 THR THR A . n A 1 189 VAL 189 189 189 VAL VAL A . n A 1 190 THR 190 190 190 THR THR A . n A 1 191 LYS 191 191 191 LYS LYS A . n A 1 192 GLY 192 192 192 GLY GLY A . n A 1 193 LYS 193 193 193 LYS LYS A . n A 1 194 ARG 194 194 194 ARG ARG A . n A 1 195 TYR 195 195 195 TYR TYR A . n A 1 196 ARG 196 196 196 ARG ARG A . n A 1 197 PHE 197 197 197 PHE PHE A . n A 1 198 ARG 198 198 198 ARG ARG A . n A 1 199 LEU 199 199 199 LEU LEU A . n A 1 200 VAL 200 200 200 VAL VAL A . n A 1 201 SER 201 201 201 SER SER A . n A 1 202 LEU 202 202 202 LEU LEU A . n A 1 203 SER 203 203 203 SER SER A . n A 1 204 CYS 204 204 204 CYS CYS A . n A 1 205 ASP 205 205 205 ASP ASP A . n A 1 206 PRO 206 206 206 PRO PRO A . n A 1 207 ASN 207 207 207 ASN ASN A . n A 1 208 HIS 208 208 208 HIS HIS A . n A 1 209 VAL 209 209 209 VAL VAL A . n A 1 210 PHE 210 210 210 PHE PHE A . n A 1 211 SER 211 211 211 SER SER A . n A 1 212 ILE 212 212 212 ILE ILE A . n A 1 213 ASP 213 213 213 ASP ASP A . n A 1 214 GLY 214 214 214 GLY GLY A . n A 1 215 HIS 215 215 215 HIS HIS A . n A 1 216 SER 216 216 216 SER SER A . n A 1 217 LEU 217 217 217 LEU LEU A . n A 1 218 THR 218 218 218 THR THR A . n A 1 219 VAL 219 219 219 VAL VAL A . n A 1 220 ILE 220 220 220 ILE ILE A . n A 1 221 GLU 221 221 221 GLU GLU A . n A 1 222 ALA 222 222 222 ALA ALA A . n A 1 223 ASP 223 223 223 ASP ASP A . n A 1 224 SER 224 224 224 SER SER A . n A 1 225 VAL 225 225 225 VAL VAL A . n A 1 226 ASN 226 226 226 ASN ASN A . n A 1 227 LEU 227 227 227 LEU LEU A . n A 1 228 LYS 228 228 228 LYS LYS A . n A 1 229 PRO 229 229 229 PRO PRO A . n A 1 230 GLN 230 230 230 GLN GLN A . n A 1 231 THR 231 231 231 THR THR A . n A 1 232 VAL 232 232 232 VAL VAL A . n A 1 233 ASP 233 233 233 ASP ASP A . n A 1 234 SER 234 234 234 SER SER A . n A 1 235 ILE 235 235 235 ILE ILE A . n A 1 236 GLN 236 236 236 GLN GLN A . n A 1 237 ILE 237 237 237 ILE ILE A . n A 1 238 PHE 238 238 238 PHE PHE A . n A 1 239 ALA 239 239 239 ALA ALA A . n A 1 240 ALA 240 240 240 ALA ALA A . n A 1 241 GLN 241 241 241 GLN GLN A . n A 1 242 ARG 242 242 242 ARG ARG A . n A 1 243 TYR 243 243 243 TYR TYR A . n A 1 244 SER 244 244 244 SER SER A . n A 1 245 PHE 245 245 245 PHE PHE A . n A 1 246 VAL 246 246 246 VAL VAL A . n A 1 247 LEU 247 247 247 LEU LEU A . n A 1 248 ASN 248 248 248 ASN ASN A . n A 1 249 ALA 249 249 249 ALA ALA A . n A 1 250 ASP 250 250 250 ASP ASP A . n A 1 251 GLN 251 251 251 GLN GLN A . n A 1 252 ASP 252 252 252 ASP ASP A . n A 1 253 VAL 253 253 253 VAL VAL A . n A 1 254 GLY 254 254 254 GLY GLY A . n A 1 255 ASN 255 255 255 ASN ASN A . n A 1 256 TYR 256 256 256 TYR TYR A . n A 1 257 TRP 257 257 257 TRP TRP A . n A 1 258 ILE 258 258 258 ILE ILE A . n A 1 259 ARG 259 259 259 ARG ARG A . n A 1 260 ALA 260 260 260 ALA ALA A . n A 1 261 LEU 261 261 261 LEU LEU A . n A 1 262 PRO 262 262 262 PRO PRO A . n A 1 263 ASN 263 263 263 ASN ASN A . n A 1 264 SER 264 264 264 SER SER A . n A 1 265 GLY 265 265 265 GLY GLY A . n A 1 266 THR 266 266 266 THR THR A . n A 1 267 ARG 267 267 267 ARG ARG A . n A 1 268 ASN 268 268 268 ASN ASN A . n A 1 269 PHE 269 269 269 PHE PHE A . n A 1 270 ASP 270 270 270 ASP ASP A . n A 1 271 GLY 271 271 271 GLY GLY A . n A 1 272 GLY 272 272 272 GLY GLY A . n A 1 273 VAL 273 273 273 VAL VAL A . n A 1 274 ASN 274 274 274 ASN ASN A . n A 1 275 SER 275 275 275 SER SER A . n A 1 276 ALA 276 276 276 ALA ALA A . n A 1 277 ILE 277 277 277 ILE ILE A . n A 1 278 LEU 278 278 278 LEU LEU A . n A 1 279 ARG 279 279 279 ARG ARG A . n A 1 280 TYR 280 280 280 TYR TYR A . n A 1 281 ASP 281 281 281 ASP ASP A . n A 1 282 GLY 282 282 282 GLY GLY A . n A 1 283 ALA 283 283 283 ALA ALA A . n A 1 284 ALA 284 284 284 ALA ALA A . n A 1 285 PRO 285 285 285 PRO PRO A . n A 1 286 VAL 286 286 286 VAL VAL A . n A 1 287 GLU 287 287 287 GLU GLU A . n A 1 288 PRO 288 288 288 PRO PRO A . n A 1 289 THR 289 289 289 THR THR A . n A 1 290 THR 290 290 290 THR THR A . n A 1 291 SER 291 291 291 SER SER A . n A 1 292 GLN 292 292 292 GLN GLN A . n A 1 293 THR 293 293 293 THR THR A . n A 1 294 PRO 294 294 294 PRO PRO A . n A 1 295 SER 295 295 295 SER SER A . n A 1 296 THR 296 296 296 THR THR A . n A 1 297 ASN 297 297 297 ASN ASN A . n A 1 298 PRO 298 298 298 PRO PRO A . n A 1 299 LEU 299 299 299 LEU LEU A . n A 1 300 VAL 300 300 300 VAL VAL A . n A 1 301 GLU 301 301 301 GLU GLU A . n A 1 302 SER 302 302 302 SER SER A . n A 1 303 ALA 303 303 303 ALA ALA A . n A 1 304 LEU 304 304 304 LEU LEU A . n A 1 305 THR 305 305 305 THR THR A . n A 1 306 THR 306 306 306 THR THR A . n A 1 307 LEU 307 307 307 LEU LEU A . n A 1 308 GLU 308 308 308 GLU GLU A . n A 1 309 GLY 309 309 309 GLY GLY A . n A 1 310 THR 310 310 310 THR THR A . n A 1 311 ALA 311 311 311 ALA ALA A . n A 1 312 ALA 312 312 312 ALA ALA A . n A 1 313 PRO 313 313 313 PRO PRO A . n A 1 314 GLY 314 314 314 GLY GLY A . n A 1 315 SER 315 315 315 SER SER A . n A 1 316 PRO 316 316 316 PRO PRO A . n A 1 317 ALA 317 317 317 ALA ALA A . n A 1 318 PRO 318 318 318 PRO PRO A . n A 1 319 GLY 319 319 319 GLY GLY A . n A 1 320 GLY 320 320 320 GLY GLY A . n A 1 321 VAL 321 321 321 VAL VAL A . n A 1 322 ASP 322 322 322 ASP ASP A . n A 1 323 LEU 323 323 323 LEU LEU A . n A 1 324 ALA 324 324 324 ALA ALA A . n A 1 325 LEU 325 325 325 LEU LEU A . n A 1 326 ASN 326 326 326 ASN ASN A . n A 1 327 MET 327 327 327 MET MET A . n A 1 328 ALA 328 328 328 ALA ALA A . n A 1 329 PHE 329 329 329 PHE PHE A . n A 1 330 GLY 330 330 330 GLY GLY A . n A 1 331 PHE 331 331 331 PHE PHE A . n A 1 332 ALA 332 332 332 ALA ALA A . n A 1 333 GLY 333 333 333 GLY GLY A . n A 1 334 GLY 334 334 334 GLY GLY A . n A 1 335 LYS 335 335 335 LYS LYS A . n A 1 336 PHE 336 336 336 PHE PHE A . n A 1 337 THR 337 337 337 THR THR A . n A 1 338 ILE 338 338 338 ILE ILE A . n A 1 339 ASN 339 339 339 ASN ASN A . n A 1 340 GLY 340 340 340 GLY GLY A . n A 1 341 ALA 341 341 341 ALA ALA A . n A 1 342 SER 342 342 342 SER SER A . n A 1 343 PHE 343 343 343 PHE PHE A . n A 1 344 THR 344 344 344 THR THR A . n A 1 345 PRO 345 345 345 PRO PRO A . n A 1 346 PRO 346 346 346 PRO PRO A . n A 1 347 THR 347 347 347 THR THR A . n A 1 348 VAL 348 348 348 VAL VAL A . n A 1 349 PRO 349 349 349 PRO PRO A . n A 1 350 VAL 350 350 350 VAL VAL A . n A 1 351 LEU 351 351 351 LEU LEU A . n A 1 352 LEU 352 352 352 LEU LEU A . n A 1 353 GLN 353 353 353 GLN GLN A . n A 1 354 ILE 354 354 354 ILE ILE A . n A 1 355 LEU 355 355 355 LEU LEU A . n A 1 356 SER 356 356 356 SER SER A . n A 1 357 GLY 357 357 357 GLY GLY A . n A 1 358 ALA 358 358 358 ALA ALA A . n A 1 359 GLN 359 359 359 GLN GLN A . n A 1 360 SER 360 360 360 SER SER A . n A 1 361 ALA 361 361 361 ALA ALA A . n A 1 362 GLN 362 362 362 GLN GLN A . n A 1 363 ASP 363 363 363 ASP ASP A . n A 1 364 LEU 364 364 364 LEU LEU A . n A 1 365 LEU 365 365 365 LEU LEU A . n A 1 366 PRO 366 366 366 PRO PRO A . n A 1 367 SER 367 367 367 SER SER A . n A 1 368 GLY 368 368 368 GLY GLY A . n A 1 369 SER 369 369 369 SER SER A . n A 1 370 VAL 370 370 370 VAL VAL A . n A 1 371 TYR 371 371 371 TYR TYR A . n A 1 372 SER 372 372 372 SER SER A . n A 1 373 LEU 373 373 373 LEU LEU A . n A 1 374 PRO 374 374 374 PRO PRO A . n A 1 375 ALA 375 375 375 ALA ALA A . n A 1 376 ASN 376 376 376 ASN ASN A . n A 1 377 ALA 377 377 377 ALA ALA A . n A 1 378 ASP 378 378 378 ASP ASP A . n A 1 379 ILE 379 379 379 ILE ILE A . n A 1 380 GLU 380 380 380 GLU GLU A . n A 1 381 ILE 381 381 381 ILE ILE A . n A 1 382 SER 382 382 382 SER SER A . n A 1 383 LEU 383 383 383 LEU LEU A . n A 1 384 PRO 384 384 384 PRO PRO A . n A 1 385 ALA 385 385 385 ALA ALA A . n A 1 386 THR 386 386 386 THR THR A . n A 1 387 ALA 387 387 387 ALA ALA A . n A 1 388 ALA 388 388 388 ALA ALA A . n A 1 389 ALA 389 389 389 ALA ALA A . n A 1 390 PRO 390 390 390 PRO PRO A . n A 1 391 GLY 391 391 391 GLY GLY A . n A 1 392 PHE 392 392 392 PHE PHE A . n A 1 393 PRO 393 393 393 PRO PRO A . n A 1 394 HIS 394 394 394 HIS HIS A . n A 1 395 PRO 395 395 395 PRO PRO A . n A 1 396 PHE 396 396 396 PHE PHE A . n A 1 397 HIS 397 397 397 HIS HIS A . n A 1 398 LEU 398 398 398 LEU LEU A . n A 1 399 HIS 399 399 399 HIS HIS A . n A 1 400 GLY 400 400 400 GLY GLY A . n A 1 401 HIS 401 401 401 HIS HIS A . n A 1 402 THR 402 402 402 THR THR A . n A 1 403 PHE 403 403 403 PHE PHE A . n A 1 404 ALA 404 404 404 ALA ALA A . n A 1 405 VAL 405 405 405 VAL VAL A . n A 1 406 VAL 406 406 406 VAL VAL A . n A 1 407 ARG 407 407 407 ARG ARG A . n A 1 408 SER 408 408 408 SER SER A . n A 1 409 ALA 409 409 409 ALA ALA A . n A 1 410 GLY 410 410 410 GLY GLY A . n A 1 411 SER 411 411 411 SER SER A . n A 1 412 SER 412 412 412 SER SER A . n A 1 413 THR 413 413 413 THR THR A . n A 1 414 TYR 414 414 414 TYR TYR A . n A 1 415 ASN 415 415 415 ASN ASN A . n A 1 416 TYR 416 416 416 TYR TYR A . n A 1 417 GLU 417 417 417 GLU GLU A . n A 1 418 ASN 418 418 418 ASN ASN A . n A 1 419 PRO 419 419 419 PRO PRO A . n A 1 420 VAL 420 420 420 VAL VAL A . n A 1 421 TYR 421 421 421 TYR TYR A . n A 1 422 ARG 422 422 422 ARG ARG A . n A 1 423 ASP 423 423 423 ASP ASP A . n A 1 424 VAL 424 424 424 VAL VAL A . n A 1 425 VAL 425 425 425 VAL VAL A . n A 1 426 SER 426 426 426 SER SER A . n A 1 427 THR 427 427 427 THR THR A . n A 1 428 GLY 428 428 428 GLY GLY A . n A 1 429 SER 429 429 429 SER SER A . n A 1 430 PRO 430 430 430 PRO PRO A . n A 1 431 GLY 431 431 431 GLY GLY A . n A 1 432 ASP 432 432 432 ASP ASP A . n A 1 433 ASN 433 433 433 ASN ASN A . n A 1 434 VAL 434 434 434 VAL VAL A . n A 1 435 THR 435 435 435 THR THR A . n A 1 436 ILE 436 436 436 ILE ILE A . n A 1 437 ARG 437 437 437 ARG ARG A . n A 1 438 PHE 438 438 438 PHE PHE A . n A 1 439 ARG 439 439 439 ARG ARG A . n A 1 440 THR 440 440 440 THR THR A . n A 1 441 ASP 441 441 441 ASP ASP A . n A 1 442 ASN 442 442 442 ASN ASN A . n A 1 443 PRO 443 443 443 PRO PRO A . n A 1 444 GLY 444 444 444 GLY GLY A . n A 1 445 PRO 445 445 445 PRO PRO A . n A 1 446 TRP 446 446 446 TRP TRP A . n A 1 447 PHE 447 447 447 PHE PHE A . n A 1 448 LEU 448 448 448 LEU LEU A . n A 1 449 HIS 449 449 449 HIS HIS A . n A 1 450 CYS 450 450 450 CYS CYS A . n A 1 451 HIS 451 451 451 HIS HIS A . n A 1 452 ILE 452 452 452 ILE ILE A . n A 1 453 ASP 453 453 453 ASP ASP A . n A 1 454 PHE 454 454 454 PHE PHE A . n A 1 455 HIS 455 455 455 HIS HIS A . n A 1 456 LEU 456 456 456 LEU LEU A . n A 1 457 GLU 457 457 457 GLU GLU A . n A 1 458 ALA 458 458 458 ALA ALA A . n A 1 459 GLY 459 459 459 GLY GLY A . n A 1 460 PHE 460 460 460 PHE PHE A . n A 1 461 ALA 461 461 461 ALA ALA A . n A 1 462 VAL 462 462 462 VAL VAL A . n A 1 463 VAL 463 463 463 VAL VAL A . n A 1 464 MET 464 464 464 MET MET A . n A 1 465 ALA 465 465 465 ALA ALA A . n A 1 466 GLU 466 466 466 GLU GLU A . n A 1 467 ASP 467 467 467 ASP ASP A . n A 1 468 ILE 468 468 468 ILE ILE A . n A 1 469 PRO 469 469 469 PRO PRO A . n A 1 470 GLU 470 470 470 GLU GLU A . n A 1 471 VAL 471 471 471 VAL VAL A . n A 1 472 ALA 472 472 472 ALA ALA A . n A 1 473 ALA 473 473 473 ALA ALA A . n A 1 474 THR 474 474 474 THR THR A . n A 1 475 ASN 475 475 475 ASN ASN A . n A 1 476 PRO 476 476 476 PRO PRO A . n A 1 477 VAL 477 477 477 VAL VAL A . n A 1 478 PRO 478 478 478 PRO PRO A . n A 1 479 GLN 479 479 479 GLN GLN A . n A 1 480 ALA 480 480 480 ALA ALA A . n A 1 481 TRP 481 481 481 TRP TRP A . n A 1 482 SER 482 482 482 SER SER A . n A 1 483 ASP 483 483 483 ASP ASP A . n A 1 484 LEU 484 484 484 LEU LEU A . n A 1 485 CYS 485 485 485 CYS CYS A . n A 1 486 PRO 486 486 486 PRO PRO A . n A 1 487 THR 487 487 487 THR THR A . n A 1 488 TYR 488 488 488 TYR TYR A . n A 1 489 ASP 489 489 489 ASP ASP A . n A 1 490 ALA 490 490 490 ALA ALA A . n A 1 491 LEU 491 491 491 LEU LEU A . n A 1 492 SER 492 492 492 SER SER A . n A 1 493 PRO 493 493 493 PRO PRO A . n A 1 494 ASP 494 494 494 ASP ASP A . n A 1 495 ASP 495 495 495 ASP ASP A . n A 1 496 GLN 496 496 496 GLN GLN A . n # loop_ _pdbx_nonpoly_scheme.asym_id _pdbx_nonpoly_scheme.entity_id _pdbx_nonpoly_scheme.mon_id _pdbx_nonpoly_scheme.ndb_seq_num _pdbx_nonpoly_scheme.pdb_seq_num _pdbx_nonpoly_scheme.auth_seq_num _pdbx_nonpoly_scheme.pdb_mon_id _pdbx_nonpoly_scheme.auth_mon_id _pdbx_nonpoly_scheme.pdb_strand_id _pdbx_nonpoly_scheme.pdb_ins_code B 2 CBS 1 1001 1 CBS CBS A . C 2 CBS 1 1006 6 CBS CBS A . D 3 CU 1 497 497 CU CU A . E 3 CU 1 498 498 CU CU A . F 3 CU 1 499 499 CU CU A . G 3 CU 1 500 500 CU CU A . H 4 HOH 1 1007 1 HOH HOH A . H 4 HOH 2 1008 2 HOH HOH A . H 4 HOH 3 1009 3 HOH HOH A . H 4 HOH 4 1010 4 HOH HOH A . H 4 HOH 5 1011 5 HOH HOH A . H 4 HOH 6 1012 6 HOH HOH A . H 4 HOH 7 1013 7 HOH HOH A . H 4 HOH 8 1014 8 HOH HOH A . H 4 HOH 9 1015 9 HOH HOH A . H 4 HOH 10 1016 10 HOH HOH A . H 4 HOH 11 1017 11 HOH HOH A . H 4 HOH 12 1018 12 HOH HOH A . H 4 HOH 13 1019 13 HOH HOH A . H 4 HOH 14 1020 14 HOH HOH A . H 4 HOH 15 1021 15 HOH HOH A . H 4 HOH 16 1022 16 HOH HOH A . H 4 HOH 17 1023 17 HOH HOH A . H 4 HOH 18 1024 18 HOH HOH A . H 4 HOH 19 1025 19 HOH HOH A . H 4 HOH 20 1026 20 HOH HOH A . H 4 HOH 21 1027 21 HOH HOH A . H 4 HOH 22 1028 22 HOH HOH A . H 4 HOH 23 1029 23 HOH HOH A . H 4 HOH 24 1030 24 HOH HOH A . H 4 HOH 25 1031 25 HOH HOH A . H 4 HOH 26 1032 26 HOH HOH A . H 4 HOH 27 1033 27 HOH HOH A . H 4 HOH 28 1034 28 HOH HOH A . H 4 HOH 29 1035 29 HOH HOH A . H 4 HOH 30 1036 30 HOH HOH A . H 4 HOH 31 1037 31 HOH HOH A . H 4 HOH 32 1038 32 HOH HOH A . H 4 HOH 33 1039 33 HOH HOH A . H 4 HOH 34 1040 34 HOH HOH A . H 4 HOH 35 1041 35 HOH HOH A . H 4 HOH 36 1042 36 HOH HOH A . H 4 HOH 37 1043 37 HOH HOH A . H 4 HOH 38 1044 38 HOH HOH A . H 4 HOH 39 1045 39 HOH HOH A . H 4 HOH 40 1046 40 HOH HOH A . H 4 HOH 41 1047 41 HOH HOH A . H 4 HOH 42 1048 42 HOH HOH A . H 4 HOH 43 1049 43 HOH HOH A . H 4 HOH 44 1050 44 HOH HOH A . H 4 HOH 45 1051 45 HOH HOH A . H 4 HOH 46 1052 46 HOH HOH A . H 4 HOH 47 1053 47 HOH HOH A . H 4 HOH 48 1054 48 HOH HOH A . H 4 HOH 49 1055 49 HOH HOH A . H 4 HOH 50 1056 50 HOH HOH A . H 4 HOH 51 1057 51 HOH HOH A . H 4 HOH 52 1058 52 HOH HOH A . H 4 HOH 53 1059 53 HOH HOH A . H 4 HOH 54 1060 54 HOH HOH A . H 4 HOH 55 1061 55 HOH HOH A . H 4 HOH 56 1062 56 HOH HOH A . H 4 HOH 57 1063 57 HOH HOH A . H 4 HOH 58 1064 58 HOH HOH A . H 4 HOH 59 1065 59 HOH HOH A . H 4 HOH 60 1066 60 HOH HOH A . H 4 HOH 61 1067 61 HOH HOH A . H 4 HOH 62 1068 62 HOH HOH A . H 4 HOH 63 1069 63 HOH HOH A . H 4 HOH 64 1070 64 HOH HOH A . H 4 HOH 65 1071 65 HOH HOH A . H 4 HOH 66 1072 66 HOH HOH A . H 4 HOH 67 1073 67 HOH HOH A . H 4 HOH 68 1074 68 HOH HOH A . H 4 HOH 69 1075 69 HOH HOH A . H 4 HOH 70 1076 70 HOH HOH A . H 4 HOH 71 1077 71 HOH HOH A . H 4 HOH 72 1078 72 HOH HOH A . H 4 HOH 73 1079 73 HOH HOH A . H 4 HOH 74 1080 74 HOH HOH A . H 4 HOH 75 1081 75 HOH HOH A . H 4 HOH 76 1082 76 HOH HOH A . H 4 HOH 77 1083 77 HOH HOH A . H 4 HOH 78 1084 78 HOH HOH A . H 4 HOH 79 1085 79 HOH HOH A . H 4 HOH 80 1086 80 HOH HOH A . H 4 HOH 81 1087 81 HOH HOH A . H 4 HOH 82 1088 82 HOH HOH A . H 4 HOH 83 1089 83 HOH HOH A . H 4 HOH 84 1090 84 HOH HOH A . H 4 HOH 85 1091 85 HOH HOH A . H 4 HOH 86 1092 86 HOH HOH A . H 4 HOH 87 1093 87 HOH HOH A . H 4 HOH 88 1094 88 HOH HOH A . H 4 HOH 89 1095 89 HOH HOH A . H 4 HOH 90 1096 90 HOH HOH A . H 4 HOH 91 1097 91 HOH HOH A . H 4 HOH 92 1098 92 HOH HOH A . H 4 HOH 93 1099 93 HOH HOH A . H 4 HOH 94 1100 94 HOH HOH A . H 4 HOH 95 1101 95 HOH HOH A . H 4 HOH 96 1102 96 HOH HOH A . H 4 HOH 97 1103 97 HOH HOH A . H 4 HOH 98 1104 98 HOH HOH A . H 4 HOH 99 1105 99 HOH HOH A . H 4 HOH 100 1106 100 HOH HOH A . H 4 HOH 101 1107 101 HOH HOH A . H 4 HOH 102 1108 102 HOH HOH A . H 4 HOH 103 1109 103 HOH HOH A . H 4 HOH 104 1110 104 HOH HOH A . H 4 HOH 105 1111 105 HOH HOH A . H 4 HOH 106 1112 106 HOH HOH A . H 4 HOH 107 1113 107 HOH HOH A . H 4 HOH 108 1114 108 HOH HOH A . H 4 HOH 109 1115 109 HOH HOH A . H 4 HOH 110 1116 110 HOH HOH A . H 4 HOH 111 1117 111 HOH HOH A . H 4 HOH 112 1118 112 HOH HOH A . H 4 HOH 113 1119 113 HOH HOH A . H 4 HOH 114 1120 114 HOH HOH A . H 4 HOH 115 1121 115 HOH HOH A . H 4 HOH 116 1122 116 HOH HOH A . H 4 HOH 117 1123 117 HOH HOH A . H 4 HOH 118 1124 118 HOH HOH A . H 4 HOH 119 1125 119 HOH HOH A . H 4 HOH 120 1126 120 HOH HOH A . H 4 HOH 121 1127 121 HOH HOH A . H 4 HOH 122 1128 122 HOH HOH A . H 4 HOH 123 1129 123 HOH HOH A . H 4 HOH 124 1130 124 HOH HOH A . H 4 HOH 125 1131 125 HOH HOH A . H 4 HOH 126 1132 126 HOH HOH A . H 4 HOH 127 1133 127 HOH HOH A . H 4 HOH 128 1134 128 HOH HOH A . H 4 HOH 129 1135 129 HOH HOH A . H 4 HOH 130 1136 130 HOH HOH A . H 4 HOH 131 1137 131 HOH HOH A . H 4 HOH 132 1138 132 HOH HOH A . H 4 HOH 133 1139 133 HOH HOH A . H 4 HOH 134 1140 134 HOH HOH A . H 4 HOH 135 1141 135 HOH HOH A . H 4 HOH 136 1142 136 HOH HOH A . H 4 HOH 137 1143 137 HOH HOH A . H 4 HOH 138 1144 138 HOH HOH A . H 4 HOH 139 1145 139 HOH HOH A . H 4 HOH 140 1146 140 HOH HOH A . H 4 HOH 141 1147 141 HOH HOH A . H 4 HOH 142 1148 142 HOH HOH A . H 4 HOH 143 1149 143 HOH HOH A . H 4 HOH 144 1150 144 HOH HOH A . H 4 HOH 145 1151 145 HOH HOH A . H 4 HOH 146 1152 146 HOH HOH A . H 4 HOH 147 1153 147 HOH HOH A . H 4 HOH 148 1154 148 HOH HOH A . H 4 HOH 149 1155 149 HOH HOH A . H 4 HOH 150 1156 150 HOH HOH A . H 4 HOH 151 1157 151 HOH HOH A . H 4 HOH 152 1158 152 HOH HOH A . H 4 HOH 153 1159 153 HOH HOH A . H 4 HOH 154 1160 154 HOH HOH A . H 4 HOH 155 1161 155 HOH HOH A . H 4 HOH 156 1162 156 HOH HOH A . H 4 HOH 157 1163 157 HOH HOH A . H 4 HOH 158 1164 158 HOH HOH A . H 4 HOH 159 1165 159 HOH HOH A . H 4 HOH 160 1166 160 HOH HOH A . H 4 HOH 161 1167 161 HOH HOH A . H 4 HOH 162 1168 162 HOH HOH A . H 4 HOH 163 1169 163 HOH HOH A . H 4 HOH 164 1170 164 HOH HOH A . H 4 HOH 165 1171 165 HOH HOH A . H 4 HOH 166 1172 166 HOH HOH A . H 4 HOH 167 1173 167 HOH HOH A . H 4 HOH 168 1174 168 HOH HOH A . H 4 HOH 169 1175 169 HOH HOH A . H 4 HOH 170 1176 170 HOH HOH A . H 4 HOH 171 1177 171 HOH HOH A . H 4 HOH 172 1178 172 HOH HOH A . H 4 HOH 173 1179 173 HOH HOH A . H 4 HOH 174 1180 174 HOH HOH A . H 4 HOH 175 1181 175 HOH HOH A . H 4 HOH 176 1182 176 HOH HOH A . H 4 HOH 177 1183 177 HOH HOH A . H 4 HOH 178 1184 178 HOH HOH A . H 4 HOH 179 1185 179 HOH HOH A . H 4 HOH 180 1186 180 HOH HOH A . H 4 HOH 181 1187 181 HOH HOH A . H 4 HOH 182 1188 182 HOH HOH A . H 4 HOH 183 1189 183 HOH HOH A . H 4 HOH 184 1190 184 HOH HOH A . H 4 HOH 185 1191 185 HOH HOH A . H 4 HOH 186 1192 186 HOH HOH A . H 4 HOH 187 1193 187 HOH HOH A . H 4 HOH 188 1194 188 HOH HOH A . H 4 HOH 189 1195 189 HOH HOH A . H 4 HOH 190 1196 190 HOH HOH A . H 4 HOH 191 1197 191 HOH HOH A . H 4 HOH 192 1198 192 HOH HOH A . H 4 HOH 193 1199 193 HOH HOH A . H 4 HOH 194 1200 194 HOH HOH A . H 4 HOH 195 1201 195 HOH HOH A . H 4 HOH 196 1202 196 HOH HOH A . H 4 HOH 197 1203 197 HOH HOH A . H 4 HOH 198 1204 198 HOH HOH A . H 4 HOH 199 1205 199 HOH HOH A . H 4 HOH 200 1206 200 HOH HOH A . H 4 HOH 201 1207 201 HOH HOH A . H 4 HOH 202 1208 202 HOH HOH A . H 4 HOH 203 1209 203 HOH HOH A . H 4 HOH 204 1210 204 HOH HOH A . H 4 HOH 205 1211 205 HOH HOH A . H 4 HOH 206 1212 206 HOH HOH A . H 4 HOH 207 1213 207 HOH HOH A . H 4 HOH 208 1214 208 HOH HOH A . H 4 HOH 209 1215 209 HOH HOH A . H 4 HOH 210 1216 210 HOH HOH A . H 4 HOH 211 1217 211 HOH HOH A . H 4 HOH 212 1218 212 HOH HOH A . H 4 HOH 213 1219 213 HOH HOH A . H 4 HOH 214 1220 214 HOH HOH A . H 4 HOH 215 1221 215 HOH HOH A . H 4 HOH 216 1222 216 HOH HOH A . H 4 HOH 217 1223 217 HOH HOH A . H 4 HOH 218 1224 218 HOH HOH A . H 4 HOH 219 1225 219 HOH HOH A . H 4 HOH 220 1226 220 HOH HOH A . H 4 HOH 221 1227 221 HOH HOH A . H 4 HOH 222 1228 222 HOH HOH A . H 4 HOH 223 1229 223 HOH HOH A . H 4 HOH 224 1230 224 HOH HOH A . H 4 HOH 225 1231 225 HOH HOH A . H 4 HOH 226 1232 226 HOH HOH A . H 4 HOH 227 1233 227 HOH HOH A . H 4 HOH 228 1234 228 HOH HOH A . H 4 HOH 229 1235 229 HOH HOH A . H 4 HOH 230 1236 230 HOH HOH A . H 4 HOH 231 1237 231 HOH HOH A . H 4 HOH 232 1238 232 HOH HOH A . H 4 HOH 233 1239 233 HOH HOH A . H 4 HOH 234 1240 234 HOH HOH A . H 4 HOH 235 1241 235 HOH HOH A . H 4 HOH 236 1242 236 HOH HOH A . H 4 HOH 237 1243 237 HOH HOH A . H 4 HOH 238 1244 238 HOH HOH A . H 4 HOH 239 1245 239 HOH HOH A . H 4 HOH 240 1246 240 HOH HOH A . H 4 HOH 241 1247 241 HOH HOH A . H 4 HOH 242 1248 242 HOH HOH A . H 4 HOH 243 1249 243 HOH HOH A . H 4 HOH 244 1250 244 HOH HOH A . H 4 HOH 245 1251 245 HOH HOH A . H 4 HOH 246 1252 246 HOH HOH A . H 4 HOH 247 1253 247 HOH HOH A . H 4 HOH 248 1254 248 HOH HOH A . H 4 HOH 249 1255 249 HOH HOH A . H 4 HOH 250 1256 250 HOH HOH A . H 4 HOH 251 1257 251 HOH HOH A . H 4 HOH 252 1258 252 HOH HOH A . H 4 HOH 253 1259 253 HOH HOH A . H 4 HOH 254 1260 254 HOH HOH A . H 4 HOH 255 1261 255 HOH HOH A . # loop_ _pdbx_struct_mod_residue.id _pdbx_struct_mod_residue.label_asym_id _pdbx_struct_mod_residue.label_comp_id _pdbx_struct_mod_residue.label_seq_id _pdbx_struct_mod_residue.auth_asym_id _pdbx_struct_mod_residue.auth_comp_id _pdbx_struct_mod_residue.auth_seq_id _pdbx_struct_mod_residue.PDB_ins_code _pdbx_struct_mod_residue.parent_comp_id _pdbx_struct_mod_residue.details 1 A ASN 54 A ASN 54 ? ASN 'GLYCOSYLATION SITE' 2 A ASN 433 A ASN 433 ? ASN 'GLYCOSYLATION SITE' # _pdbx_struct_assembly.id 1 _pdbx_struct_assembly.details author_defined_assembly _pdbx_struct_assembly.method_details ? _pdbx_struct_assembly.oligomeric_details monomeric _pdbx_struct_assembly.oligomeric_count 1 # _pdbx_struct_assembly_gen.assembly_id 1 _pdbx_struct_assembly_gen.oper_expression 1 _pdbx_struct_assembly_gen.asym_id_list A,B,C,D,E,F,G,H # _pdbx_struct_oper_list.id 1 _pdbx_struct_oper_list.type 'identity operation' _pdbx_struct_oper_list.name 1_555 _pdbx_struct_oper_list.symmetry_operation x,y,z _pdbx_struct_oper_list.matrix[1][1] 1.0000000000 _pdbx_struct_oper_list.matrix[1][2] 0.0000000000 _pdbx_struct_oper_list.matrix[1][3] 0.0000000000 _pdbx_struct_oper_list.vector[1] 0.0000000000 _pdbx_struct_oper_list.matrix[2][1] 0.0000000000 _pdbx_struct_oper_list.matrix[2][2] 1.0000000000 _pdbx_struct_oper_list.matrix[2][3] 0.0000000000 _pdbx_struct_oper_list.vector[2] 0.0000000000 _pdbx_struct_oper_list.matrix[3][1] 0.0000000000 _pdbx_struct_oper_list.matrix[3][2] 0.0000000000 _pdbx_struct_oper_list.matrix[3][3] 1.0000000000 _pdbx_struct_oper_list.vector[3] 0.0000000000 # loop_ _pdbx_struct_conn_angle.id _pdbx_struct_conn_angle.ptnr1_label_atom_id _pdbx_struct_conn_angle.ptnr1_label_alt_id _pdbx_struct_conn_angle.ptnr1_label_asym_id _pdbx_struct_conn_angle.ptnr1_label_comp_id _pdbx_struct_conn_angle.ptnr1_label_seq_id _pdbx_struct_conn_angle.ptnr1_auth_atom_id _pdbx_struct_conn_angle.ptnr1_auth_asym_id _pdbx_struct_conn_angle.ptnr1_auth_comp_id _pdbx_struct_conn_angle.ptnr1_auth_seq_id _pdbx_struct_conn_angle.ptnr1_PDB_ins_code _pdbx_struct_conn_angle.ptnr1_symmetry _pdbx_struct_conn_angle.ptnr2_label_atom_id _pdbx_struct_conn_angle.ptnr2_label_alt_id _pdbx_struct_conn_angle.ptnr2_label_asym_id _pdbx_struct_conn_angle.ptnr2_label_comp_id _pdbx_struct_conn_angle.ptnr2_label_seq_id _pdbx_struct_conn_angle.ptnr2_auth_atom_id _pdbx_struct_conn_angle.ptnr2_auth_asym_id _pdbx_struct_conn_angle.ptnr2_auth_comp_id _pdbx_struct_conn_angle.ptnr2_auth_seq_id _pdbx_struct_conn_angle.ptnr2_PDB_ins_code _pdbx_struct_conn_angle.ptnr2_symmetry _pdbx_struct_conn_angle.ptnr3_label_atom_id _pdbx_struct_conn_angle.ptnr3_label_alt_id _pdbx_struct_conn_angle.ptnr3_label_asym_id _pdbx_struct_conn_angle.ptnr3_label_comp_id _pdbx_struct_conn_angle.ptnr3_label_seq_id _pdbx_struct_conn_angle.ptnr3_auth_atom_id _pdbx_struct_conn_angle.ptnr3_auth_asym_id _pdbx_struct_conn_angle.ptnr3_auth_comp_id _pdbx_struct_conn_angle.ptnr3_auth_seq_id _pdbx_struct_conn_angle.ptnr3_PDB_ins_code _pdbx_struct_conn_angle.ptnr3_symmetry _pdbx_struct_conn_angle.value _pdbx_struct_conn_angle.value_esd 1 NE2 ? A HIS 64 ? A HIS 64 ? 1_555 CU ? E CU . ? A CU 498 ? 1_555 NE2 ? A HIS 397 ? A HIS 397 ? 1_555 172.5 ? 2 ND1 ? A HIS 66 ? A HIS 66 ? 1_555 CU ? G CU . ? A CU 500 ? 1_555 NE2 ? A HIS 109 ? A HIS 109 ? 1_555 93.9 ? 3 ND1 ? A HIS 66 ? A HIS 66 ? 1_555 CU ? G CU . ? A CU 500 ? 1_555 NE2 ? A HIS 451 ? A HIS 451 ? 1_555 96.3 ? 4 NE2 ? A HIS 109 ? A HIS 109 ? 1_555 CU ? G CU . ? A CU 500 ? 1_555 NE2 ? A HIS 451 ? A HIS 451 ? 1_555 97.0 ? 5 ND1 ? A HIS 394 ? A HIS 394 ? 1_555 CU ? D CU . ? A CU 497 ? 1_555 ND1 ? A HIS 455 ? A HIS 455 ? 1_555 111.4 ? 6 NE2 ? A HIS 399 ? A HIS 399 ? 1_555 CU ? F CU . ? A CU 499 ? 1_555 NE2 ? A HIS 449 ? A HIS 449 ? 1_555 107.1 ? # loop_ _pdbx_audit_revision_history.ordinal _pdbx_audit_revision_history.data_content_type _pdbx_audit_revision_history.major_revision _pdbx_audit_revision_history.minor_revision _pdbx_audit_revision_history.revision_date 1 'Structure model' 1 0 2007-09-11 2 'Structure model' 1 1 2011-07-13 3 'Structure model' 1 2 2016-12-21 4 'Structure model' 1 3 2017-04-19 # _pdbx_audit_revision_details.ordinal 1 _pdbx_audit_revision_details.revision_ordinal 1 _pdbx_audit_revision_details.data_content_type 'Structure model' _pdbx_audit_revision_details.provider repository _pdbx_audit_revision_details.type 'Initial release' _pdbx_audit_revision_details.description ? # loop_ _pdbx_audit_revision_group.ordinal _pdbx_audit_revision_group.revision_ordinal _pdbx_audit_revision_group.data_content_type _pdbx_audit_revision_group.group 1 2 'Structure model' 'Version format compliance' 2 3 'Structure model' 'Structure summary' 3 4 'Structure model' 'Database references' # loop_ _software.name _software.classification _software.version _software.citation_id _software.pdbx_ordinal REFMAC refinement 5.2.0019 ? 1 MOSFLM 'data reduction' . ? 2 SCALA 'data scaling' . ? 3 MOLREP phasing . ? 4 # loop_ _pdbx_validate_close_contact.id _pdbx_validate_close_contact.PDB_model_num _pdbx_validate_close_contact.auth_atom_id_1 _pdbx_validate_close_contact.auth_asym_id_1 _pdbx_validate_close_contact.auth_comp_id_1 _pdbx_validate_close_contact.auth_seq_id_1 _pdbx_validate_close_contact.PDB_ins_code_1 _pdbx_validate_close_contact.label_alt_id_1 _pdbx_validate_close_contact.auth_atom_id_2 _pdbx_validate_close_contact.auth_asym_id_2 _pdbx_validate_close_contact.auth_comp_id_2 _pdbx_validate_close_contact.auth_seq_id_2 _pdbx_validate_close_contact.PDB_ins_code_2 _pdbx_validate_close_contact.label_alt_id_2 _pdbx_validate_close_contact.dist 1 1 C A VAL 286 ? ? H A GLU 287 ? ? 1.11 2 1 C A SER 291 ? ? H A GLN 292 ? ? 1.44 # loop_ _pdbx_validate_rmsd_angle.id _pdbx_validate_rmsd_angle.PDB_model_num _pdbx_validate_rmsd_angle.auth_atom_id_1 _pdbx_validate_rmsd_angle.auth_asym_id_1 _pdbx_validate_rmsd_angle.auth_comp_id_1 _pdbx_validate_rmsd_angle.auth_seq_id_1 _pdbx_validate_rmsd_angle.PDB_ins_code_1 _pdbx_validate_rmsd_angle.label_alt_id_1 _pdbx_validate_rmsd_angle.auth_atom_id_2 _pdbx_validate_rmsd_angle.auth_asym_id_2 _pdbx_validate_rmsd_angle.auth_comp_id_2 _pdbx_validate_rmsd_angle.auth_seq_id_2 _pdbx_validate_rmsd_angle.PDB_ins_code_2 _pdbx_validate_rmsd_angle.label_alt_id_2 _pdbx_validate_rmsd_angle.auth_atom_id_3 _pdbx_validate_rmsd_angle.auth_asym_id_3 _pdbx_validate_rmsd_angle.auth_comp_id_3 _pdbx_validate_rmsd_angle.auth_seq_id_3 _pdbx_validate_rmsd_angle.PDB_ins_code_3 _pdbx_validate_rmsd_angle.label_alt_id_3 _pdbx_validate_rmsd_angle.angle_value _pdbx_validate_rmsd_angle.angle_target_value _pdbx_validate_rmsd_angle.angle_deviation _pdbx_validate_rmsd_angle.angle_standard_deviation _pdbx_validate_rmsd_angle.linker_flag 1 1 NE A ARG 194 ? ? CZ A ARG 194 ? ? NH1 A ARG 194 ? ? 123.62 120.30 3.32 0.50 N 2 1 NE A ARG 194 ? ? CZ A ARG 194 ? ? NH2 A ARG 194 ? ? 116.96 120.30 -3.34 0.50 N 3 1 N A ASP 441 ? ? CA A ASP 441 ? ? CB A ASP 441 ? ? 96.22 110.60 -14.38 1.80 N # loop_ _pdbx_validate_torsion.id _pdbx_validate_torsion.PDB_model_num _pdbx_validate_torsion.auth_comp_id _pdbx_validate_torsion.auth_asym_id _pdbx_validate_torsion.auth_seq_id _pdbx_validate_torsion.PDB_ins_code _pdbx_validate_torsion.label_alt_id _pdbx_validate_torsion.phi _pdbx_validate_torsion.psi 1 1 SER A 16 ? ? -151.98 63.97 2 1 ASN A 28 ? ? 34.27 55.42 3 1 LEU A 58 ? ? 75.46 117.81 4 1 ASP A 101 ? ? 54.72 -3.03 5 1 SER A 113 ? ? 44.76 -129.18 6 1 ASP A 140 ? ? -152.42 82.92 7 1 THR A 179 ? ? -142.68 53.32 8 1 LEU A 180 ? ? -65.07 1.76 9 1 ASP A 205 ? ? -156.23 -69.71 10 1 ASP A 223 ? ? 38.81 48.70 11 1 ALA A 240 ? ? 86.98 -12.85 12 1 VAL A 253 ? ? -30.69 125.19 13 1 ASN A 268 ? ? 38.36 -179.76 14 1 PRO A 285 ? ? -62.25 54.13 15 1 SER A 295 ? ? 13.39 156.73 16 1 THR A 296 ? ? -88.36 -138.21 17 1 ASN A 297 ? ? 32.12 43.28 18 1 PRO A 316 ? ? -66.25 58.54 19 1 ALA A 332 ? ? -85.96 -98.70 20 1 ASN A 418 ? ? -150.24 52.25 21 1 PRO A 430 ? ? -37.99 123.28 # _pdbx_validate_peptide_omega.id 1 _pdbx_validate_peptide_omega.PDB_model_num 1 _pdbx_validate_peptide_omega.auth_comp_id_1 ASP _pdbx_validate_peptide_omega.auth_asym_id_1 A _pdbx_validate_peptide_omega.auth_seq_id_1 441 _pdbx_validate_peptide_omega.PDB_ins_code_1 ? _pdbx_validate_peptide_omega.label_alt_id_1 ? _pdbx_validate_peptide_omega.auth_comp_id_2 ASN _pdbx_validate_peptide_omega.auth_asym_id_2 A _pdbx_validate_peptide_omega.auth_seq_id_2 442 _pdbx_validate_peptide_omega.PDB_ins_code_2 ? _pdbx_validate_peptide_omega.label_alt_id_2 ? _pdbx_validate_peptide_omega.omega -148.45 # loop_ _pdbx_entity_nonpoly.entity_id _pdbx_entity_nonpoly.name _pdbx_entity_nonpoly.comp_id 2 'DI(N-ACETYL-D-GLUCOSAMINE)' CBS 3 'COPPER (II) ION' CU 4 water HOH #