data_2ADD # _entry.id 2ADD # _audit_conform.dict_name mmcif_pdbx.dic _audit_conform.dict_version 5.279 _audit_conform.dict_location http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic # loop_ _database_2.database_id _database_2.database_code PDB 2ADD RCSB RCSB033763 WWPDB D_1000033763 # loop_ _pdbx_database_related.db_name _pdbx_database_related.db_id _pdbx_database_related.details _pdbx_database_related.content_type PDB 2ADE 'Crystal structure of fructan 1-exohydrolase IIa from Cichorium intybus in complex with fructose' unspecified PDB 2AEY 'Crystal structure of fructan 1-exohydrolase IIa from Cichorium intybus in complex with 2,5 dideoxy-2,5-immino-D-mannitol' unspecified PDB 2AEZ 'Crystal structure of fructan 1-exohydrolase IIa (E201Q) from Cichorium intybus in complex with 1-kestose' unspecified # _pdbx_database_status.status_code REL _pdbx_database_status.entry_id 2ADD _pdbx_database_status.recvd_initial_deposition_date 2005-07-20 _pdbx_database_status.deposit_site RCSB _pdbx_database_status.process_site RCSB _pdbx_database_status.status_code_sf REL _pdbx_database_status.status_code_mr ? _pdbx_database_status.SG_entry ? _pdbx_database_status.pdb_format_compatible Y _pdbx_database_status.status_code_cs ? # loop_ _audit_author.name _audit_author.pdbx_ordinal 'Verhaest, M.' 1 'Le Roy, K.' 2 'De Ranter, C.J.' 3 'Van Laere, A.' 4 'Van den Ende, W.' 5 'Rabijns, A.' 6 # _citation.id primary _citation.title ;Insights into the fine architecture of the active site of chicory fructan 1-exohydrolase: 1-kestose as substrate vs sucrose as inhibitor. ; _citation.journal_abbrev 'New Phytol' _citation.journal_volume 174 _citation.page_first 90 _citation.page_last 100 _citation.year 2007 _citation.journal_id_ASTM ? _citation.country ? _citation.journal_id_ISSN ? _citation.journal_id_CSD 0353 _citation.book_publisher ? _citation.pdbx_database_id_PubMed 17335500 _citation.pdbx_database_id_DOI 10.1111/j.1469-8137.2007.01988.x # loop_ _citation_author.citation_id _citation_author.name _citation_author.ordinal primary 'Verhaest, M.' 1 primary 'Lammens, W.' 2 primary 'Le Roy, K.' 3 primary 'De Ranter, C.J.' 4 primary 'Van Laere, A.' 5 primary 'Rabijns, A.' 6 primary 'Van den Ende, W.' 7 # _cell.entry_id 2ADD _cell.length_a 139.320 _cell.length_b 139.320 _cell.length_c 182.750 _cell.angle_alpha 90.00 _cell.angle_beta 90.00 _cell.angle_gamma 90.00 _cell.Z_PDB 8 _cell.pdbx_unique_axis ? _cell.length_a_esd ? _cell.length_b_esd ? _cell.length_c_esd ? _cell.angle_alpha_esd ? _cell.angle_beta_esd ? _cell.angle_gamma_esd ? # _symmetry.entry_id 2ADD _symmetry.space_group_name_H-M 'P 41 21 2' _symmetry.pdbx_full_space_group_name_H-M ? _symmetry.cell_setting ? _symmetry.Int_Tables_number 92 _symmetry.space_group_name_Hall ? # loop_ _entity.id _entity.type _entity.src_method _entity.pdbx_description _entity.formula_weight _entity.pdbx_number_of_molecules _entity.pdbx_ec _entity.pdbx_mutation _entity.pdbx_fragment _entity.details 1 polymer man 'fructan 1-exohydrolase IIa' 61115.965 1 3.2.1.153 ? ? ? 2 non-polymer man N-ACETYL-D-GLUCOSAMINE 221.208 4 ? ? ? ? 3 non-polymer man ALPHA-D-MANNOSE 180.156 1 ? ? ? ? 4 non-polymer man SUCROSE 342.296 1 ? ? ? ? 5 water nat water 18.015 363 ? ? ? ? # _entity_poly.entity_id 1 _entity_poly.type 'polypeptide(L)' _entity_poly.nstd_linkage no _entity_poly.nstd_monomer no _entity_poly.pdbx_seq_one_letter_code ;QQIEQPYRTGYHFQPPSNWMNDPNGPMLYQGVYHFFYQYNPYAATFGDVIIWGHAVSYDLVNWIHLDPAIYPTQEADSKS CWSGSATILPGNIPAMLYTGSDSKSRQVQDLAWPKNLSDPFLREWVKHPKNPLITPPEGVKDDCFRDPSTAWLGPDGVWR IVVGGDRDNNGMAFLYQSTDFVNWKRYDQPLSSADATGTWECPDFYPVPLNSTNGLDTSVYGGSVRHVMKAGFEGHDWYT IGTYSPDRENFLPQNGLSLTGSTLDLRYDYGQFYASKSFFDDAKNRRVLWAWVPETDSQADDIEKGWAGLQSFPRALWID RNGKQLIQWPVEEIEELRQNQVNLQNKNLKPGSVLEIHGIAASQADVTISFKLEGLKEAEVLDTTLVDPQALCNERGASS RGALGPFGLLAMASKDLKEQSAIFFRVFQNQLGRYSVLMCSDLSRSTVRSNIDTTSYGAFVDIDPRSEEISLRNLIDHSI IESFGAGGKTCITSRIYPKFVNNEEAHLFVFNNGTQNVKISEMSAWSMKNAKFVVDQSVKSAA ; _entity_poly.pdbx_seq_one_letter_code_can ;QQIEQPYRTGYHFQPPSNWMNDPNGPMLYQGVYHFFYQYNPYAATFGDVIIWGHAVSYDLVNWIHLDPAIYPTQEADSKS CWSGSATILPGNIPAMLYTGSDSKSRQVQDLAWPKNLSDPFLREWVKHPKNPLITPPEGVKDDCFRDPSTAWLGPDGVWR IVVGGDRDNNGMAFLYQSTDFVNWKRYDQPLSSADATGTWECPDFYPVPLNSTNGLDTSVYGGSVRHVMKAGFEGHDWYT IGTYSPDRENFLPQNGLSLTGSTLDLRYDYGQFYASKSFFDDAKNRRVLWAWVPETDSQADDIEKGWAGLQSFPRALWID RNGKQLIQWPVEEIEELRQNQVNLQNKNLKPGSVLEIHGIAASQADVTISFKLEGLKEAEVLDTTLVDPQALCNERGASS RGALGPFGLLAMASKDLKEQSAIFFRVFQNQLGRYSVLMCSDLSRSTVRSNIDTTSYGAFVDIDPRSEEISLRNLIDHSI IESFGAGGKTCITSRIYPKFVNNEEAHLFVFNNGTQNVKISEMSAWSMKNAKFVVDQSVKSAA ; _entity_poly.pdbx_strand_id A _entity_poly.pdbx_target_identifier ? # loop_ _entity_poly_seq.entity_id _entity_poly_seq.num _entity_poly_seq.mon_id _entity_poly_seq.hetero 1 1 GLN n 1 2 GLN n 1 3 ILE n 1 4 GLU n 1 5 GLN n 1 6 PRO n 1 7 TYR n 1 8 ARG n 1 9 THR n 1 10 GLY n 1 11 TYR n 1 12 HIS n 1 13 PHE n 1 14 GLN n 1 15 PRO n 1 16 PRO n 1 17 SER n 1 18 ASN n 1 19 TRP n 1 20 MET n 1 21 ASN n 1 22 ASP n 1 23 PRO n 1 24 ASN n 1 25 GLY n 1 26 PRO n 1 27 MET n 1 28 LEU n 1 29 TYR n 1 30 GLN n 1 31 GLY n 1 32 VAL n 1 33 TYR n 1 34 HIS n 1 35 PHE n 1 36 PHE n 1 37 TYR n 1 38 GLN n 1 39 TYR n 1 40 ASN n 1 41 PRO n 1 42 TYR n 1 43 ALA n 1 44 ALA n 1 45 THR n 1 46 PHE n 1 47 GLY n 1 48 ASP n 1 49 VAL n 1 50 ILE n 1 51 ILE n 1 52 TRP n 1 53 GLY n 1 54 HIS n 1 55 ALA n 1 56 VAL n 1 57 SER n 1 58 TYR n 1 59 ASP n 1 60 LEU n 1 61 VAL n 1 62 ASN n 1 63 TRP n 1 64 ILE n 1 65 HIS n 1 66 LEU n 1 67 ASP n 1 68 PRO n 1 69 ALA n 1 70 ILE n 1 71 TYR n 1 72 PRO n 1 73 THR n 1 74 GLN n 1 75 GLU n 1 76 ALA n 1 77 ASP n 1 78 SER n 1 79 LYS n 1 80 SER n 1 81 CYS n 1 82 TRP n 1 83 SER n 1 84 GLY n 1 85 SER n 1 86 ALA n 1 87 THR n 1 88 ILE n 1 89 LEU n 1 90 PRO n 1 91 GLY n 1 92 ASN n 1 93 ILE n 1 94 PRO n 1 95 ALA n 1 96 MET n 1 97 LEU n 1 98 TYR n 1 99 THR n 1 100 GLY n 1 101 SER n 1 102 ASP n 1 103 SER n 1 104 LYS n 1 105 SER n 1 106 ARG n 1 107 GLN n 1 108 VAL n 1 109 GLN n 1 110 ASP n 1 111 LEU n 1 112 ALA n 1 113 TRP n 1 114 PRO n 1 115 LYS n 1 116 ASN n 1 117 LEU n 1 118 SER n 1 119 ASP n 1 120 PRO n 1 121 PHE n 1 122 LEU n 1 123 ARG n 1 124 GLU n 1 125 TRP n 1 126 VAL n 1 127 LYS n 1 128 HIS n 1 129 PRO n 1 130 LYS n 1 131 ASN n 1 132 PRO n 1 133 LEU n 1 134 ILE n 1 135 THR n 1 136 PRO n 1 137 PRO n 1 138 GLU n 1 139 GLY n 1 140 VAL n 1 141 LYS n 1 142 ASP n 1 143 ASP n 1 144 CYS n 1 145 PHE n 1 146 ARG n 1 147 ASP n 1 148 PRO n 1 149 SER n 1 150 THR n 1 151 ALA n 1 152 TRP n 1 153 LEU n 1 154 GLY n 1 155 PRO n 1 156 ASP n 1 157 GLY n 1 158 VAL n 1 159 TRP n 1 160 ARG n 1 161 ILE n 1 162 VAL n 1 163 VAL n 1 164 GLY n 1 165 GLY n 1 166 ASP n 1 167 ARG n 1 168 ASP n 1 169 ASN n 1 170 ASN n 1 171 GLY n 1 172 MET n 1 173 ALA n 1 174 PHE n 1 175 LEU n 1 176 TYR n 1 177 GLN n 1 178 SER n 1 179 THR n 1 180 ASP n 1 181 PHE n 1 182 VAL n 1 183 ASN n 1 184 TRP n 1 185 LYS n 1 186 ARG n 1 187 TYR n 1 188 ASP n 1 189 GLN n 1 190 PRO n 1 191 LEU n 1 192 SER n 1 193 SER n 1 194 ALA n 1 195 ASP n 1 196 ALA n 1 197 THR n 1 198 GLY n 1 199 THR n 1 200 TRP n 1 201 GLU n 1 202 CYS n 1 203 PRO n 1 204 ASP n 1 205 PHE n 1 206 TYR n 1 207 PRO n 1 208 VAL n 1 209 PRO n 1 210 LEU n 1 211 ASN n 1 212 SER n 1 213 THR n 1 214 ASN n 1 215 GLY n 1 216 LEU n 1 217 ASP n 1 218 THR n 1 219 SER n 1 220 VAL n 1 221 TYR n 1 222 GLY n 1 223 GLY n 1 224 SER n 1 225 VAL n 1 226 ARG n 1 227 HIS n 1 228 VAL n 1 229 MET n 1 230 LYS n 1 231 ALA n 1 232 GLY n 1 233 PHE n 1 234 GLU n 1 235 GLY n 1 236 HIS n 1 237 ASP n 1 238 TRP n 1 239 TYR n 1 240 THR n 1 241 ILE n 1 242 GLY n 1 243 THR n 1 244 TYR n 1 245 SER n 1 246 PRO n 1 247 ASP n 1 248 ARG n 1 249 GLU n 1 250 ASN n 1 251 PHE n 1 252 LEU n 1 253 PRO n 1 254 GLN n 1 255 ASN n 1 256 GLY n 1 257 LEU n 1 258 SER n 1 259 LEU n 1 260 THR n 1 261 GLY n 1 262 SER n 1 263 THR n 1 264 LEU n 1 265 ASP n 1 266 LEU n 1 267 ARG n 1 268 TYR n 1 269 ASP n 1 270 TYR n 1 271 GLY n 1 272 GLN n 1 273 PHE n 1 274 TYR n 1 275 ALA n 1 276 SER n 1 277 LYS n 1 278 SER n 1 279 PHE n 1 280 PHE n 1 281 ASP n 1 282 ASP n 1 283 ALA n 1 284 LYS n 1 285 ASN n 1 286 ARG n 1 287 ARG n 1 288 VAL n 1 289 LEU n 1 290 TRP n 1 291 ALA n 1 292 TRP n 1 293 VAL n 1 294 PRO n 1 295 GLU n 1 296 THR n 1 297 ASP n 1 298 SER n 1 299 GLN n 1 300 ALA n 1 301 ASP n 1 302 ASP n 1 303 ILE n 1 304 GLU n 1 305 LYS n 1 306 GLY n 1 307 TRP n 1 308 ALA n 1 309 GLY n 1 310 LEU n 1 311 GLN n 1 312 SER n 1 313 PHE n 1 314 PRO n 1 315 ARG n 1 316 ALA n 1 317 LEU n 1 318 TRP n 1 319 ILE n 1 320 ASP n 1 321 ARG n 1 322 ASN n 1 323 GLY n 1 324 LYS n 1 325 GLN n 1 326 LEU n 1 327 ILE n 1 328 GLN n 1 329 TRP n 1 330 PRO n 1 331 VAL n 1 332 GLU n 1 333 GLU n 1 334 ILE n 1 335 GLU n 1 336 GLU n 1 337 LEU n 1 338 ARG n 1 339 GLN n 1 340 ASN n 1 341 GLN n 1 342 VAL n 1 343 ASN n 1 344 LEU n 1 345 GLN n 1 346 ASN n 1 347 LYS n 1 348 ASN n 1 349 LEU n 1 350 LYS n 1 351 PRO n 1 352 GLY n 1 353 SER n 1 354 VAL n 1 355 LEU n 1 356 GLU n 1 357 ILE n 1 358 HIS n 1 359 GLY n 1 360 ILE n 1 361 ALA n 1 362 ALA n 1 363 SER n 1 364 GLN n 1 365 ALA n 1 366 ASP n 1 367 VAL n 1 368 THR n 1 369 ILE n 1 370 SER n 1 371 PHE n 1 372 LYS n 1 373 LEU n 1 374 GLU n 1 375 GLY n 1 376 LEU n 1 377 LYS n 1 378 GLU n 1 379 ALA n 1 380 GLU n 1 381 VAL n 1 382 LEU n 1 383 ASP n 1 384 THR n 1 385 THR n 1 386 LEU n 1 387 VAL n 1 388 ASP n 1 389 PRO n 1 390 GLN n 1 391 ALA n 1 392 LEU n 1 393 CYS n 1 394 ASN n 1 395 GLU n 1 396 ARG n 1 397 GLY n 1 398 ALA n 1 399 SER n 1 400 SER n 1 401 ARG n 1 402 GLY n 1 403 ALA n 1 404 LEU n 1 405 GLY n 1 406 PRO n 1 407 PHE n 1 408 GLY n 1 409 LEU n 1 410 LEU n 1 411 ALA n 1 412 MET n 1 413 ALA n 1 414 SER n 1 415 LYS n 1 416 ASP n 1 417 LEU n 1 418 LYS n 1 419 GLU n 1 420 GLN n 1 421 SER n 1 422 ALA n 1 423 ILE n 1 424 PHE n 1 425 PHE n 1 426 ARG n 1 427 VAL n 1 428 PHE n 1 429 GLN n 1 430 ASN n 1 431 GLN n 1 432 LEU n 1 433 GLY n 1 434 ARG n 1 435 TYR n 1 436 SER n 1 437 VAL n 1 438 LEU n 1 439 MET n 1 440 CYS n 1 441 SER n 1 442 ASP n 1 443 LEU n 1 444 SER n 1 445 ARG n 1 446 SER n 1 447 THR n 1 448 VAL n 1 449 ARG n 1 450 SER n 1 451 ASN n 1 452 ILE n 1 453 ASP n 1 454 THR n 1 455 THR n 1 456 SER n 1 457 TYR n 1 458 GLY n 1 459 ALA n 1 460 PHE n 1 461 VAL n 1 462 ASP n 1 463 ILE n 1 464 ASP n 1 465 PRO n 1 466 ARG n 1 467 SER n 1 468 GLU n 1 469 GLU n 1 470 ILE n 1 471 SER n 1 472 LEU n 1 473 ARG n 1 474 ASN n 1 475 LEU n 1 476 ILE n 1 477 ASP n 1 478 HIS n 1 479 SER n 1 480 ILE n 1 481 ILE n 1 482 GLU n 1 483 SER n 1 484 PHE n 1 485 GLY n 1 486 ALA n 1 487 GLY n 1 488 GLY n 1 489 LYS n 1 490 THR n 1 491 CYS n 1 492 ILE n 1 493 THR n 1 494 SER n 1 495 ARG n 1 496 ILE n 1 497 TYR n 1 498 PRO n 1 499 LYS n 1 500 PHE n 1 501 VAL n 1 502 ASN n 1 503 ASN n 1 504 GLU n 1 505 GLU n 1 506 ALA n 1 507 HIS n 1 508 LEU n 1 509 PHE n 1 510 VAL n 1 511 PHE n 1 512 ASN n 1 513 ASN n 1 514 GLY n 1 515 THR n 1 516 GLN n 1 517 ASN n 1 518 VAL n 1 519 LYS n 1 520 ILE n 1 521 SER n 1 522 GLU n 1 523 MET n 1 524 SER n 1 525 ALA n 1 526 TRP n 1 527 SER n 1 528 MET n 1 529 LYS n 1 530 ASN n 1 531 ALA n 1 532 LYS n 1 533 PHE n 1 534 VAL n 1 535 VAL n 1 536 ASP n 1 537 GLN n 1 538 SER n 1 539 VAL n 1 540 LYS n 1 541 SER n 1 542 ALA n 1 543 ALA n # _entity_src_gen.entity_id 1 _entity_src_gen.pdbx_src_id 1 _entity_src_gen.pdbx_alt_source_flag sample _entity_src_gen.pdbx_seq_type ? _entity_src_gen.pdbx_beg_seq_num ? _entity_src_gen.pdbx_end_seq_num ? _entity_src_gen.gene_src_common_name chicory _entity_src_gen.gene_src_genus Cichorium _entity_src_gen.pdbx_gene_src_gene '1-feh IIa' _entity_src_gen.gene_src_species ? _entity_src_gen.gene_src_strain ? _entity_src_gen.gene_src_tissue ? _entity_src_gen.gene_src_tissue_fraction ? _entity_src_gen.gene_src_details ? _entity_src_gen.pdbx_gene_src_fragment ? _entity_src_gen.pdbx_gene_src_scientific_name 'Cichorium intybus' _entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 13427 _entity_src_gen.pdbx_gene_src_variant ? _entity_src_gen.pdbx_gene_src_cell_line ? _entity_src_gen.pdbx_gene_src_atcc ? _entity_src_gen.pdbx_gene_src_organ ? _entity_src_gen.pdbx_gene_src_organelle ? _entity_src_gen.pdbx_gene_src_cell ? _entity_src_gen.pdbx_gene_src_cellular_location ? _entity_src_gen.host_org_common_name ? _entity_src_gen.pdbx_host_org_scientific_name 'Pichia pastoris' _entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 4922 _entity_src_gen.host_org_genus Pichia _entity_src_gen.pdbx_host_org_gene ? _entity_src_gen.pdbx_host_org_organ ? _entity_src_gen.host_org_species ? _entity_src_gen.pdbx_host_org_tissue ? _entity_src_gen.pdbx_host_org_tissue_fraction ? _entity_src_gen.pdbx_host_org_strain ? _entity_src_gen.pdbx_host_org_variant ? _entity_src_gen.pdbx_host_org_cell_line ? _entity_src_gen.pdbx_host_org_atcc ? _entity_src_gen.pdbx_host_org_culture_collection ? _entity_src_gen.pdbx_host_org_cell ? _entity_src_gen.pdbx_host_org_organelle ? _entity_src_gen.pdbx_host_org_cellular_location ? _entity_src_gen.pdbx_host_org_vector_type ? _entity_src_gen.pdbx_host_org_vector ? _entity_src_gen.host_org_details ? _entity_src_gen.expression_system_id ? _entity_src_gen.plasmid_name ? _entity_src_gen.plasmid_details ? _entity_src_gen.pdbx_description ? # _struct_ref.id 1 _struct_ref.db_name UNP _struct_ref.db_code Q93X60_CICIN _struct_ref.pdbx_db_accession Q93X60 _struct_ref.entity_id 1 _struct_ref.pdbx_align_begin 39 _struct_ref.pdbx_seq_one_letter_code ? _struct_ref.pdbx_db_isoform ? # _struct_ref_seq.align_id 1 _struct_ref_seq.ref_id 1 _struct_ref_seq.pdbx_PDB_id_code 2ADD _struct_ref_seq.pdbx_strand_id A _struct_ref_seq.seq_align_beg 1 _struct_ref_seq.pdbx_seq_align_beg_ins_code ? _struct_ref_seq.seq_align_end 543 _struct_ref_seq.pdbx_seq_align_end_ins_code ? _struct_ref_seq.pdbx_db_accession Q93X60 _struct_ref_seq.db_align_beg 39 _struct_ref_seq.pdbx_db_align_beg_ins_code ? _struct_ref_seq.db_align_end 581 _struct_ref_seq.pdbx_db_align_end_ins_code ? _struct_ref_seq.pdbx_auth_seq_align_beg 1 _struct_ref_seq.pdbx_auth_seq_align_end 543 # loop_ _chem_comp.id _chem_comp.type _chem_comp.mon_nstd_flag _chem_comp.name _chem_comp.pdbx_synonyms _chem_comp.formula _chem_comp.formula_weight ALA 'L-peptide linking' y ALANINE ? 'C3 H7 N O2' 89.093 ARG 'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1' 175.209 ASN 'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3' 132.118 ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4' 133.103 CYS 'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S' 121.158 GLN 'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3' 146.144 GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4' 147.129 GLY 'peptide linking' y GLYCINE ? 'C2 H5 N O2' 75.067 HIS 'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1' 156.162 HOH non-polymer . WATER ? 'H2 O' 18.015 ILE 'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2' 131.173 LEU 'L-peptide linking' y LEUCINE ? 'C6 H13 N O2' 131.173 LYS 'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1' 147.195 MAN D-saccharide . ALPHA-D-MANNOSE ? 'C6 H12 O6' 180.156 MET 'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S' 149.211 NAG D-saccharide . N-ACETYL-D-GLUCOSAMINE ? 'C8 H15 N O6' 221.208 PHE 'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2' 165.189 PRO 'L-peptide linking' y PROLINE ? 'C5 H9 N O2' 115.130 SER 'L-peptide linking' y SERINE ? 'C3 H7 N O3' 105.093 SUC saccharide . SUCROSE ? 'C12 H22 O11' 342.296 THR 'L-peptide linking' y THREONINE ? 'C4 H9 N O3' 119.119 TRP 'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2' 204.225 TYR 'L-peptide linking' y TYROSINE ? 'C9 H11 N O3' 181.189 VAL 'L-peptide linking' y VALINE ? 'C5 H11 N O2' 117.146 # _exptl.entry_id 2ADD _exptl.method 'X-RAY DIFFRACTION' _exptl.crystals_number 1 # _exptl_crystal.id 1 _exptl_crystal.density_meas ? _exptl_crystal.density_Matthews 7.2 _exptl_crystal.density_percent_sol 82 _exptl_crystal.description ? _exptl_crystal.F_000 ? _exptl_crystal.preparation ? # _exptl_crystal_grow.crystal_id 1 _exptl_crystal_grow.method 'VAPOR DIFFUSION, HANGING DROP' _exptl_crystal_grow.temp 277 _exptl_crystal_grow.temp_details ? _exptl_crystal_grow.pH 7.0 _exptl_crystal_grow.pdbx_details 'sodium potassium phosphate , potassium phosphate, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K' _exptl_crystal_grow.pdbx_pH_range . # _diffrn.id 1 _diffrn.ambient_temp 100 _diffrn.ambient_temp_details ? _diffrn.crystal_id 1 # _diffrn_detector.diffrn_id 1 _diffrn_detector.detector CCD _diffrn_detector.type MARRESEARCH _diffrn_detector.pdbx_collection_date 2004-12-17 _diffrn_detector.details 'bent mirror' # _diffrn_radiation.diffrn_id 1 _diffrn_radiation.wavelength_id 1 _diffrn_radiation.pdbx_monochromatic_or_laue_m_l M _diffrn_radiation.monochromator 'triangular monocromator' _diffrn_radiation.pdbx_diffrn_protocol 'SINGLE WAVELENGTH' _diffrn_radiation.pdbx_scattering_type x-ray # _diffrn_radiation_wavelength.id 1 _diffrn_radiation_wavelength.wavelength 0.931 _diffrn_radiation_wavelength.wt 1.0 # _diffrn_source.diffrn_id 1 _diffrn_source.source SYNCHROTRON _diffrn_source.type 'ESRF BEAMLINE ID14-3' _diffrn_source.pdbx_synchrotron_site ESRF _diffrn_source.pdbx_synchrotron_beamline ID14-3 _diffrn_source.pdbx_wavelength ? _diffrn_source.pdbx_wavelength_list 0.931 # _reflns.entry_id 2ADD _reflns.observed_criterion_sigma_I 2 _reflns.observed_criterion_sigma_F 1.41 _reflns.d_resolution_low 30 _reflns.d_resolution_high 2.5 _reflns.number_obs 62661 _reflns.number_all 62965 _reflns.percent_possible_obs 91.8 _reflns.pdbx_Rmerge_I_obs 0.071 _reflns.pdbx_Rsym_value ? _reflns.pdbx_netI_over_sigmaI ? _reflns.B_iso_Wilson_estimate 38.0 _reflns.pdbx_redundancy 7.4 _reflns.R_free_details ? _reflns.limit_h_max ? _reflns.limit_h_min ? _reflns.limit_k_max ? _reflns.limit_k_min ? _reflns.limit_l_max ? _reflns.limit_l_min ? _reflns.observed_criterion_F_max ? _reflns.observed_criterion_F_min ? _reflns.pdbx_chi_squared ? _reflns.pdbx_scaling_rejects ? _reflns.pdbx_ordinal 1 _reflns.pdbx_diffrn_id 1 # _reflns_shell.d_res_high 2.50 _reflns_shell.d_res_low 2.54 _reflns_shell.percent_possible_all 100 _reflns_shell.Rmerge_I_obs 0.289 _reflns_shell.pdbx_Rsym_value ? _reflns_shell.meanI_over_sigI_obs ? _reflns_shell.pdbx_redundancy ? _reflns_shell.percent_possible_obs ? _reflns_shell.number_unique_all 3092 _reflns_shell.number_measured_all ? _reflns_shell.number_measured_obs ? _reflns_shell.number_unique_obs ? _reflns_shell.pdbx_chi_squared ? _reflns_shell.pdbx_ordinal 1 _reflns_shell.pdbx_diffrn_id 1 # _refine.entry_id 2ADD _refine.ls_number_reflns_obs 60982 _refine.ls_number_reflns_all 60982 _refine.pdbx_ls_sigma_I 0.0 _refine.pdbx_ls_sigma_F 0.0 _refine.pdbx_data_cutoff_high_absF 99933.52 _refine.pdbx_data_cutoff_low_absF 0.000000 _refine.pdbx_data_cutoff_high_rms_absF ? _refine.ls_d_res_low 29.50 _refine.ls_d_res_high 2.50 _refine.ls_percent_reflns_obs 97.3 _refine.ls_R_factor_obs 0.197 _refine.ls_R_factor_all ? _refine.ls_R_factor_R_work 0.197 _refine.ls_R_factor_R_free 0.218 _refine.ls_R_factor_R_free_error 0.004 _refine.ls_R_factor_R_free_error_details ? _refine.ls_percent_reflns_R_free 5.1 _refine.ls_number_reflns_R_free 3088 _refine.ls_number_parameters ? _refine.ls_number_restraints ? _refine.occupancy_min ? _refine.occupancy_max ? _refine.correlation_coeff_Fo_to_Fc ? _refine.correlation_coeff_Fo_to_Fc_free ? _refine.B_iso_mean 29.8 _refine.aniso_B[1][1] 4.04 _refine.aniso_B[2][2] 4.04 _refine.aniso_B[3][3] -8.07 _refine.aniso_B[1][2] 0.00 _refine.aniso_B[1][3] 0.00 _refine.aniso_B[2][3] 0.00 _refine.solvent_model_details 'FLAT MODEL' _refine.solvent_model_param_ksol 0.364233 _refine.solvent_model_param_bsol 33.3248 _refine.pdbx_solvent_vdw_probe_radii ? _refine.pdbx_solvent_ion_probe_radii ? _refine.pdbx_solvent_shrinkage_radii ? _refine.pdbx_ls_cross_valid_method THROUGHOUT _refine.details ? _refine.pdbx_starting_model 'PDB ENTRY 1ST8' _refine.pdbx_method_to_determine_struct 'MOLECULAR REPLACEMENT' _refine.pdbx_isotropic_thermal_model RESTRAINED _refine.pdbx_stereochemistry_target_values 'Engh & Huber' _refine.pdbx_stereochem_target_val_spec_case ? _refine.pdbx_R_Free_selection_details RANDOM _refine.pdbx_overall_ESU_R ? _refine.pdbx_overall_ESU_R_Free ? _refine.overall_SU_ML ? _refine.overall_SU_B ? _refine.ls_redundancy_reflns_obs ? _refine.B_iso_min ? _refine.B_iso_max ? _refine.overall_SU_R_Cruickshank_DPI ? _refine.overall_SU_R_free ? _refine.ls_wR_factor_R_free ? _refine.ls_wR_factor_R_work ? _refine.overall_FOM_free_R_set ? _refine.overall_FOM_work_R_set ? _refine.pdbx_overall_phase_error ? _refine.pdbx_refine_id 'X-RAY DIFFRACTION' _refine.pdbx_diffrn_id 1 _refine.pdbx_TLS_residual_ADP_flag ? _refine.pdbx_overall_SU_R_free_Cruickshank_DPI ? _refine.pdbx_overall_SU_R_Blow_DPI ? _refine.pdbx_overall_SU_R_free_Blow_DPI ? # _refine_analyze.entry_id 2ADD _refine_analyze.Luzzati_coordinate_error_obs 0.28 _refine_analyze.Luzzati_sigma_a_obs 0.25 _refine_analyze.Luzzati_d_res_low_obs 5.00 _refine_analyze.Luzzati_coordinate_error_free 0.31 _refine_analyze.Luzzati_sigma_a_free 0.28 _refine_analyze.Luzzati_d_res_low_free ? _refine_analyze.number_disordered_residues ? _refine_analyze.occupancy_sum_hydrogen ? _refine_analyze.occupancy_sum_non_hydrogen ? _refine_analyze.pdbx_Luzzati_d_res_high_obs ? _refine_analyze.pdbx_refine_id 'X-RAY DIFFRACTION' # _refine_hist.pdbx_refine_id 'X-RAY DIFFRACTION' _refine_hist.cycle_id LAST _refine_hist.pdbx_number_atoms_protein 4274 _refine_hist.pdbx_number_atoms_nucleic_acid 0 _refine_hist.pdbx_number_atoms_ligand 90 _refine_hist.number_atoms_solvent 363 _refine_hist.number_atoms_total 4727 _refine_hist.d_res_high 2.50 _refine_hist.d_res_low 29.50 # loop_ _refine_ls_restr.type _refine_ls_restr.dev_ideal _refine_ls_restr.dev_ideal_target _refine_ls_restr.weight _refine_ls_restr.number _refine_ls_restr.pdbx_refine_id _refine_ls_restr.pdbx_restraint_function c_bond_d 0.006 ? ? ? 'X-RAY DIFFRACTION' ? c_bond_d_na ? ? ? ? 'X-RAY DIFFRACTION' ? c_bond_d_prot ? ? ? ? 'X-RAY DIFFRACTION' ? c_angle_d ? ? ? ? 'X-RAY DIFFRACTION' ? c_angle_d_na ? ? ? ? 'X-RAY DIFFRACTION' ? c_angle_d_prot ? ? ? ? 'X-RAY DIFFRACTION' ? c_angle_deg 1.4 ? ? ? 'X-RAY DIFFRACTION' ? c_angle_deg_na ? ? ? ? 'X-RAY DIFFRACTION' ? c_angle_deg_prot ? ? ? ? 'X-RAY DIFFRACTION' ? c_dihedral_angle_d 25.9 ? ? ? 'X-RAY DIFFRACTION' ? c_dihedral_angle_d_na ? ? ? ? 'X-RAY DIFFRACTION' ? c_dihedral_angle_d_prot ? ? ? ? 'X-RAY DIFFRACTION' ? c_improper_angle_d 0.97 ? ? ? 'X-RAY DIFFRACTION' ? c_improper_angle_d_na ? ? ? ? 'X-RAY DIFFRACTION' ? c_improper_angle_d_prot ? ? ? ? 'X-RAY DIFFRACTION' ? c_mcbond_it 1.15 1.50 ? ? 'X-RAY DIFFRACTION' ? c_mcangle_it 1.89 2.00 ? ? 'X-RAY DIFFRACTION' ? c_scbond_it 2.13 2.00 ? ? 'X-RAY DIFFRACTION' ? c_scangle_it 3.15 2.50 ? ? 'X-RAY DIFFRACTION' ? # _refine_ls_shell.pdbx_total_number_of_bins_used 6 _refine_ls_shell.d_res_high 2.50 _refine_ls_shell.d_res_low 2.66 _refine_ls_shell.number_reflns_R_work 9101 _refine_ls_shell.R_factor_R_work 0.257 _refine_ls_shell.percent_reflns_obs 93.7 _refine_ls_shell.R_factor_R_free 0.292 _refine_ls_shell.R_factor_R_free_error 0.013 _refine_ls_shell.percent_reflns_R_free 5.3 _refine_ls_shell.number_reflns_R_free 509 _refine_ls_shell.number_reflns_obs ? _refine_ls_shell.redundancy_reflns_obs ? _refine_ls_shell.number_reflns_all ? _refine_ls_shell.R_factor_all ? _refine_ls_shell.pdbx_refine_id 'X-RAY DIFFRACTION' # loop_ _pdbx_xplor_file.serial_no _pdbx_xplor_file.param_file _pdbx_xplor_file.topol_file _pdbx_xplor_file.pdbx_refine_id 1 protein_rep.param protein.top 'X-RAY DIFFRACTION' 2 water_rep.param water.top 'X-RAY DIFFRACTION' 3 carbohydrate.param carbohydrate.top 'X-RAY DIFFRACTION' 4 gol.param gol.top 'X-RAY DIFFRACTION' 5 sucr.param sucr.top 'X-RAY DIFFRACTION' # _struct.entry_id 2ADD _struct.title 'Crystal structure of fructan 1-exohydrolase IIa from Cichorium intybus in complex with sucrose' _struct.pdbx_descriptor 'fructan 1-exohydrolase IIa (E.C.3.2.1.153)' _struct.pdbx_model_details ? _struct.pdbx_CASP_flag ? _struct.pdbx_model_type_details ? # _struct_keywords.entry_id 2ADD _struct_keywords.pdbx_keywords HYDROLASE _struct_keywords.text 'five fold beta propeller, HYDROLASE' # loop_ _struct_asym.id _struct_asym.pdbx_blank_PDB_chainid_flag _struct_asym.pdbx_modified _struct_asym.entity_id _struct_asym.details A N N 1 ? B N N 2 ? C N N 2 ? D N N 3 ? E N N 2 ? F N N 2 ? G N N 4 ? H N N 5 ? # _struct_biol.id 1 # loop_ _struct_conf.conf_type_id _struct_conf.id _struct_conf.pdbx_PDB_helix_id _struct_conf.beg_label_comp_id _struct_conf.beg_label_asym_id _struct_conf.beg_label_seq_id _struct_conf.pdbx_beg_PDB_ins_code _struct_conf.end_label_comp_id _struct_conf.end_label_asym_id _struct_conf.end_label_seq_id _struct_conf.pdbx_end_PDB_ins_code _struct_conf.beg_auth_comp_id _struct_conf.beg_auth_asym_id _struct_conf.beg_auth_seq_id _struct_conf.end_auth_comp_id _struct_conf.end_auth_asym_id _struct_conf.end_auth_seq_id _struct_conf.pdbx_PDB_helix_class _struct_conf.details _struct_conf.pdbx_PDB_helix_length HELX_P HELX_P1 1 GLN A 74 ? SER A 78 ? GLN A 74 SER A 78 5 ? 5 HELX_P HELX_P2 2 SER A 298 ? GLY A 306 ? SER A 298 GLY A 306 1 ? 9 HELX_P HELX_P3 3 GLU A 332 ? GLU A 336 ? GLU A 332 GLU A 336 5 ? 5 HELX_P HELX_P4 4 GLY A 375 ? ALA A 379 ? GLY A 375 ALA A 379 5 ? 5 HELX_P HELX_P5 5 ASP A 388 ? ARG A 396 ? ASP A 388 ARG A 396 1 ? 9 HELX_P HELX_P6 6 LYS A 499 ? ASN A 503 ? LYS A 499 ASN A 503 5 ? 5 # _struct_conf_type.id HELX_P _struct_conf_type.criteria ? _struct_conf_type.reference ? # loop_ _struct_conn.id _struct_conn.conn_type_id _struct_conn.pdbx_leaving_atom_flag _struct_conn.pdbx_PDB_id _struct_conn.ptnr1_label_asym_id _struct_conn.ptnr1_label_comp_id _struct_conn.ptnr1_label_seq_id _struct_conn.ptnr1_label_atom_id _struct_conn.pdbx_ptnr1_label_alt_id _struct_conn.pdbx_ptnr1_PDB_ins_code _struct_conn.pdbx_ptnr1_standard_comp_id _struct_conn.ptnr1_symmetry _struct_conn.ptnr2_label_asym_id _struct_conn.ptnr2_label_comp_id _struct_conn.ptnr2_label_seq_id _struct_conn.ptnr2_label_atom_id _struct_conn.pdbx_ptnr2_label_alt_id _struct_conn.pdbx_ptnr2_PDB_ins_code _struct_conn.ptnr1_auth_asym_id _struct_conn.ptnr1_auth_comp_id _struct_conn.ptnr1_auth_seq_id _struct_conn.ptnr2_auth_asym_id _struct_conn.ptnr2_auth_comp_id _struct_conn.ptnr2_auth_seq_id _struct_conn.ptnr2_symmetry _struct_conn.pdbx_ptnr3_label_atom_id _struct_conn.pdbx_ptnr3_label_seq_id _struct_conn.pdbx_ptnr3_label_comp_id _struct_conn.pdbx_ptnr3_label_asym_id _struct_conn.pdbx_ptnr3_label_alt_id _struct_conn.pdbx_ptnr3_PDB_ins_code _struct_conn.details _struct_conn.pdbx_dist_value _struct_conn.pdbx_value_order disulf1 disulf ? ? A CYS 393 SG ? ? ? 1_555 A CYS 440 SG ? ? A CYS 393 A CYS 440 1_555 ? ? ? ? ? ? ? 2.035 ? covale1 covale ? ? A ASN 116 ND2 ? ? ? 1_555 E NAG . C1 ? ? A ASN 116 A NAG 680 1_555 ? ? ? ? ? ? ? 1.448 ? covale2 covale ? ? A ASN 513 ND2 ? ? ? 1_555 B NAG . C1 ? ? A ASN 513 A NAG 650 1_555 ? ? ? ? ? ? ? 1.453 ? covale3 covale ? ? B NAG . O4 ? ? ? 1_555 C NAG . C1 ? ? A NAG 650 A NAG 660 1_555 ? ? ? ? ? ? ? 1.393 ? covale4 covale ? ? C NAG . O4 ? ? ? 1_555 D MAN . C1 ? ? A NAG 660 A MAN 670 1_555 ? ? ? ? ? ? ? 1.393 ? covale5 covale ? ? E NAG . O4 ? ? ? 1_555 F NAG . C1 ? ? A NAG 680 A NAG 690 1_555 ? ? ? ? ? ? ? 1.387 ? # loop_ _struct_conn_type.id _struct_conn_type.criteria _struct_conn_type.reference disulf ? ? covale ? ? # loop_ _struct_mon_prot_cis.pdbx_id _struct_mon_prot_cis.label_comp_id _struct_mon_prot_cis.label_seq_id _struct_mon_prot_cis.label_asym_id _struct_mon_prot_cis.label_alt_id _struct_mon_prot_cis.pdbx_PDB_ins_code _struct_mon_prot_cis.auth_comp_id _struct_mon_prot_cis.auth_seq_id _struct_mon_prot_cis.auth_asym_id _struct_mon_prot_cis.pdbx_label_comp_id_2 _struct_mon_prot_cis.pdbx_label_seq_id_2 _struct_mon_prot_cis.pdbx_label_asym_id_2 _struct_mon_prot_cis.pdbx_PDB_ins_code_2 _struct_mon_prot_cis.pdbx_auth_comp_id_2 _struct_mon_prot_cis.pdbx_auth_seq_id_2 _struct_mon_prot_cis.pdbx_auth_asym_id_2 _struct_mon_prot_cis.pdbx_PDB_model_num _struct_mon_prot_cis.pdbx_omega_angle 1 ASN 131 A . ? ASN 131 A PRO 132 A ? PRO 132 A 1 0.13 2 GLY 405 A . ? GLY 405 A PRO 406 A ? PRO 406 A 1 0.10 # loop_ _struct_sheet.id _struct_sheet.type _struct_sheet.number_strands _struct_sheet.details A ? 6 ? B ? 4 ? C ? 4 ? D ? 4 ? E ? 4 ? F ? 4 ? G ? 3 ? H ? 4 ? I ? 6 ? J ? 5 ? K ? 6 ? # loop_ _struct_sheet_order.sheet_id _struct_sheet_order.range_id_1 _struct_sheet_order.range_id_2 _struct_sheet_order.offset _struct_sheet_order.sense A 1 2 ? parallel A 2 3 ? anti-parallel A 3 4 ? anti-parallel A 4 5 ? anti-parallel A 5 6 ? parallel B 1 2 ? anti-parallel B 2 3 ? anti-parallel B 3 4 ? anti-parallel C 1 2 ? anti-parallel C 2 3 ? anti-parallel C 3 4 ? anti-parallel D 1 2 ? anti-parallel D 2 3 ? anti-parallel D 3 4 ? anti-parallel E 1 2 ? anti-parallel E 2 3 ? anti-parallel E 3 4 ? anti-parallel F 1 2 ? anti-parallel F 2 3 ? anti-parallel F 3 4 ? anti-parallel G 1 2 ? anti-parallel G 2 3 ? anti-parallel H 1 2 ? anti-parallel H 2 3 ? anti-parallel H 3 4 ? anti-parallel I 1 2 ? anti-parallel I 2 3 ? anti-parallel I 3 4 ? anti-parallel I 4 5 ? anti-parallel I 5 6 ? anti-parallel J 1 2 ? anti-parallel J 2 3 ? anti-parallel J 3 4 ? anti-parallel J 4 5 ? parallel K 1 2 ? anti-parallel K 2 3 ? anti-parallel K 3 4 ? anti-parallel K 4 5 ? anti-parallel K 5 6 ? anti-parallel # loop_ _struct_sheet_range.sheet_id _struct_sheet_range.id _struct_sheet_range.beg_label_comp_id _struct_sheet_range.beg_label_asym_id _struct_sheet_range.beg_label_seq_id _struct_sheet_range.pdbx_beg_PDB_ins_code _struct_sheet_range.end_label_comp_id _struct_sheet_range.end_label_asym_id _struct_sheet_range.end_label_seq_id _struct_sheet_range.pdbx_end_PDB_ins_code _struct_sheet_range.beg_auth_comp_id _struct_sheet_range.beg_auth_asym_id _struct_sheet_range.beg_auth_seq_id _struct_sheet_range.end_auth_comp_id _struct_sheet_range.end_auth_asym_id _struct_sheet_range.end_auth_seq_id A 1 TRP A 307 ? ALA A 308 ? TRP A 307 ALA A 308 A 2 ASN A 18 ? TYR A 29 ? ASN A 18 TYR A 29 A 3 VAL A 32 ? ASN A 40 ? VAL A 32 ASN A 40 A 4 ILE A 51 ? SER A 57 ? ILE A 51 SER A 57 A 5 TRP A 63 ? HIS A 65 ? TRP A 63 HIS A 65 A 6 PHE A 533 ? VAL A 535 ? PHE A 533 VAL A 535 B 1 SER A 80 ? LEU A 89 ? SER A 80 LEU A 89 B 2 ILE A 93 ? SER A 101 ? ILE A 93 SER A 101 B 3 GLN A 107 ? PRO A 114 ? GLN A 107 PRO A 114 B 4 TRP A 125 ? LYS A 127 ? TRP A 125 LYS A 127 C 1 PHE A 145 ? ARG A 146 ? PHE A 145 ARG A 146 C 2 TRP A 159 ? ARG A 167 ? TRP A 159 ARG A 167 C 3 ASN A 170 ? SER A 178 ? ASN A 170 SER A 178 C 4 LYS A 185 ? ARG A 186 ? LYS A 185 ARG A 186 D 1 TRP A 152 ? LEU A 153 ? TRP A 152 LEU A 153 D 2 TRP A 159 ? ARG A 167 ? TRP A 159 ARG A 167 D 3 ASN A 170 ? SER A 178 ? ASN A 170 SER A 178 D 4 SER A 192 ? ALA A 194 ? SER A 192 ALA A 194 E 1 GLU A 201 ? PRO A 209 ? GLU A 201 PRO A 209 E 2 VAL A 225 ? PHE A 233 ? VAL A 225 PHE A 233 E 3 HIS A 236 ? SER A 245 ? HIS A 236 SER A 245 E 4 ASN A 250 ? PRO A 253 ? ASN A 250 PRO A 253 F 1 GLU A 201 ? PRO A 209 ? GLU A 201 PRO A 209 F 2 VAL A 225 ? PHE A 233 ? VAL A 225 PHE A 233 F 3 HIS A 236 ? SER A 245 ? HIS A 236 SER A 245 F 4 LEU A 266 ? ARG A 267 ? LEU A 266 ARG A 267 G 1 TYR A 274 ? ASP A 281 ? TYR A 274 ASP A 281 G 2 ARG A 286 ? VAL A 293 ? ARG A 286 VAL A 293 G 3 LEU A 310 ? GLN A 311 ? LEU A 310 GLN A 311 H 1 TYR A 274 ? ASP A 281 ? TYR A 274 ASP A 281 H 2 ARG A 286 ? VAL A 293 ? ARG A 286 VAL A 293 H 3 ARG A 315 ? ILE A 319 ? ARG A 315 ILE A 319 H 4 LEU A 326 ? PRO A 330 ? LEU A 326 PRO A 330 I 1 ARG A 338 ? LEU A 349 ? ARG A 338 LEU A 349 I 2 VAL A 518 ? MET A 528 ? VAL A 518 MET A 528 I 3 GLN A 364 ? LEU A 373 ? GLN A 364 LEU A 373 I 4 ILE A 470 ? ASP A 477 ? ILE A 470 ASP A 477 I 5 ILE A 480 ? GLY A 485 ? ILE A 480 GLY A 485 I 6 THR A 490 ? ARG A 495 ? THR A 490 ARG A 495 J 1 SER A 353 ? GLU A 356 ? SER A 353 GLU A 356 J 2 HIS A 507 ? ASN A 512 ? HIS A 507 ASN A 512 J 3 PHE A 407 ? ALA A 413 ? PHE A 407 ALA A 413 J 4 SER A 421 ? GLN A 429 ? SER A 421 GLN A 429 J 5 GLU A 380 ? VAL A 381 ? GLU A 380 VAL A 381 K 1 SER A 353 ? GLU A 356 ? SER A 353 GLU A 356 K 2 HIS A 507 ? ASN A 512 ? HIS A 507 ASN A 512 K 3 PHE A 407 ? ALA A 413 ? PHE A 407 ALA A 413 K 4 SER A 421 ? GLN A 429 ? SER A 421 GLN A 429 K 5 TYR A 435 ? ASP A 442 ? TYR A 435 ASP A 442 K 6 TYR A 457 ? VAL A 461 ? TYR A 457 VAL A 461 # loop_ _pdbx_struct_sheet_hbond.sheet_id _pdbx_struct_sheet_hbond.range_id_1 _pdbx_struct_sheet_hbond.range_id_2 _pdbx_struct_sheet_hbond.range_1_label_atom_id _pdbx_struct_sheet_hbond.range_1_label_comp_id _pdbx_struct_sheet_hbond.range_1_label_asym_id _pdbx_struct_sheet_hbond.range_1_label_seq_id _pdbx_struct_sheet_hbond.range_1_PDB_ins_code _pdbx_struct_sheet_hbond.range_1_auth_atom_id _pdbx_struct_sheet_hbond.range_1_auth_comp_id _pdbx_struct_sheet_hbond.range_1_auth_asym_id _pdbx_struct_sheet_hbond.range_1_auth_seq_id _pdbx_struct_sheet_hbond.range_2_label_atom_id _pdbx_struct_sheet_hbond.range_2_label_comp_id _pdbx_struct_sheet_hbond.range_2_label_asym_id _pdbx_struct_sheet_hbond.range_2_label_seq_id _pdbx_struct_sheet_hbond.range_2_PDB_ins_code _pdbx_struct_sheet_hbond.range_2_auth_atom_id _pdbx_struct_sheet_hbond.range_2_auth_comp_id _pdbx_struct_sheet_hbond.range_2_auth_asym_id _pdbx_struct_sheet_hbond.range_2_auth_seq_id A 1 2 O ALA A 308 ? O ALA A 308 N MET A 20 ? N MET A 20 A 2 3 N ASN A 24 ? N ASN A 24 O PHE A 36 ? O PHE A 36 A 3 4 N TYR A 33 ? N TYR A 33 O SER A 57 ? O SER A 57 A 4 5 N VAL A 56 ? N VAL A 56 O ILE A 64 ? O ILE A 64 A 5 6 N HIS A 65 ? N HIS A 65 O VAL A 534 ? O VAL A 534 B 1 2 N THR A 87 ? N THR A 87 O ALA A 95 ? O ALA A 95 B 2 3 N GLY A 100 ? N GLY A 100 O VAL A 108 ? O VAL A 108 B 3 4 N TRP A 113 ? N TRP A 113 O VAL A 126 ? O VAL A 126 C 1 2 N ARG A 146 ? N ARG A 146 O GLY A 164 ? O GLY A 164 C 2 3 N TRP A 159 ? N TRP A 159 O SER A 178 ? O SER A 178 C 3 4 N GLN A 177 ? N GLN A 177 O LYS A 185 ? O LYS A 185 D 1 2 N TRP A 152 ? N TRP A 152 O ARG A 160 ? O ARG A 160 D 2 3 N TRP A 159 ? N TRP A 159 O SER A 178 ? O SER A 178 D 3 4 N ALA A 173 ? N ALA A 173 O SER A 192 ? O SER A 192 E 1 2 N GLU A 201 ? N GLU A 201 O GLY A 232 ? O GLY A 232 E 2 3 N HIS A 227 ? N HIS A 227 O GLY A 242 ? O GLY A 242 E 3 4 N THR A 243 ? N THR A 243 O LEU A 252 ? O LEU A 252 F 1 2 N GLU A 201 ? N GLU A 201 O GLY A 232 ? O GLY A 232 F 2 3 N HIS A 227 ? N HIS A 227 O GLY A 242 ? O GLY A 242 F 3 4 N TYR A 239 ? N TYR A 239 O LEU A 266 ? O LEU A 266 G 1 2 N ASP A 281 ? N ASP A 281 O ARG A 286 ? O ARG A 286 G 2 3 N VAL A 293 ? N VAL A 293 O LEU A 310 ? O LEU A 310 H 1 2 N ASP A 281 ? N ASP A 281 O ARG A 286 ? O ARG A 286 H 2 3 N LEU A 289 ? N LEU A 289 O ARG A 315 ? O ARG A 315 H 3 4 N ALA A 316 ? N ALA A 316 O TRP A 329 ? O TRP A 329 I 1 2 N LYS A 347 ? N LYS A 347 O ILE A 520 ? O ILE A 520 I 2 3 O SER A 524 ? O SER A 524 N THR A 368 ? N THR A 368 I 3 4 N VAL A 367 ? N VAL A 367 O ASN A 474 ? O ASN A 474 I 4 5 N ARG A 473 ? N ARG A 473 O PHE A 484 ? O PHE A 484 I 5 6 N GLY A 485 ? N GLY A 485 O THR A 490 ? O THR A 490 J 1 2 N LEU A 355 ? N LEU A 355 O VAL A 510 ? O VAL A 510 J 2 3 O PHE A 511 ? O PHE A 511 N GLY A 408 ? N GLY A 408 J 3 4 N ALA A 411 ? N ALA A 411 O SER A 421 ? O SER A 421 J 4 5 O GLN A 429 ? O GLN A 429 N GLU A 380 ? N GLU A 380 K 1 2 N LEU A 355 ? N LEU A 355 O VAL A 510 ? O VAL A 510 K 2 3 O PHE A 511 ? O PHE A 511 N GLY A 408 ? N GLY A 408 K 3 4 N ALA A 411 ? N ALA A 411 O SER A 421 ? O SER A 421 K 4 5 N PHE A 424 ? N PHE A 424 O CYS A 440 ? O CYS A 440 K 5 6 N SER A 441 ? N SER A 441 O TYR A 457 ? O TYR A 457 # loop_ _struct_site.id _struct_site.pdbx_evidence_code _struct_site.pdbx_auth_asym_id _struct_site.pdbx_auth_comp_id _struct_site.pdbx_auth_seq_id _struct_site.pdbx_auth_ins_code _struct_site.pdbx_num_residues _struct_site.details AC1 Software ? ? ? ? 7 'BINDING SITE FOR RESIDUE NAG A 650' AC2 Software ? ? ? ? 4 'BINDING SITE FOR RESIDUE NAG A 660' AC3 Software ? ? ? ? 1 'BINDING SITE FOR RESIDUE MAN A 670' AC4 Software ? ? ? ? 6 'BINDING SITE FOR RESIDUE NAG A 680' AC5 Software ? ? ? ? 1 'BINDING SITE FOR RESIDUE NAG A 690' AC6 Software ? ? ? ? 15 'BINDING SITE FOR RESIDUE SUC A 800' # loop_ _struct_site_gen.id _struct_site_gen.site_id _struct_site_gen.pdbx_num_res _struct_site_gen.label_comp_id _struct_site_gen.label_asym_id _struct_site_gen.label_seq_id _struct_site_gen.pdbx_auth_ins_code _struct_site_gen.auth_comp_id _struct_site_gen.auth_asym_id _struct_site_gen.auth_seq_id _struct_site_gen.label_atom_id _struct_site_gen.label_alt_id _struct_site_gen.symmetry _struct_site_gen.details 1 AC1 7 ALA A 398 ? ALA A 398 . ? 1_555 ? 2 AC1 7 SER A 399 ? SER A 399 . ? 1_555 ? 3 AC1 7 GLN A 420 ? GLN A 420 . ? 1_555 ? 4 AC1 7 ARG A 445 ? ARG A 445 . ? 1_555 ? 5 AC1 7 ASN A 513 ? ASN A 513 . ? 1_555 ? 6 AC1 7 NAG C . ? NAG A 660 . ? 1_555 ? 7 AC1 7 HOH H . ? HOH A 1256 . ? 1_555 ? 8 AC2 4 ARG A 445 ? ARG A 445 . ? 1_555 ? 9 AC2 4 NAG B . ? NAG A 650 . ? 1_555 ? 10 AC2 4 MAN D . ? MAN A 670 . ? 1_555 ? 11 AC2 4 HOH H . ? HOH A 1293 . ? 1_555 ? 12 AC3 1 NAG C . ? NAG A 660 . ? 1_555 ? 13 AC4 6 ASN A 116 ? ASN A 116 . ? 1_555 ? 14 AC4 6 SER A 118 ? SER A 118 . ? 1_555 ? 15 AC4 6 ASP A 119 ? ASP A 119 . ? 1_555 ? 16 AC4 6 NAG F . ? NAG A 690 . ? 1_555 ? 17 AC4 6 HOH H . ? HOH A 1337 . ? 1_555 ? 18 AC4 6 HOH H . ? HOH A 1358 . ? 1_555 ? 19 AC5 1 NAG E . ? NAG A 680 . ? 1_555 ? 20 AC6 15 ASN A 21 ? ASN A 21 . ? 1_555 ? 21 AC6 15 ASP A 22 ? ASP A 22 . ? 1_555 ? 22 AC6 15 GLN A 38 ? GLN A 38 . ? 1_555 ? 23 AC6 15 PHE A 46 ? PHE A 46 . ? 1_555 ? 24 AC6 15 TRP A 82 ? TRP A 82 . ? 1_555 ? 25 AC6 15 SER A 83 ? SER A 83 . ? 1_555 ? 26 AC6 15 GLN A 107 ? GLN A 107 . ? 1_555 ? 27 AC6 15 ARG A 146 ? ARG A 146 . ? 1_555 ? 28 AC6 15 ASP A 147 ? ASP A 147 . ? 1_555 ? 29 AC6 15 GLU A 201 ? GLU A 201 . ? 1_555 ? 30 AC6 15 TYR A 274 ? TYR A 274 . ? 1_555 ? 31 AC6 15 HOH H . ? HOH A 1238 . ? 1_555 ? 32 AC6 15 HOH H . ? HOH A 1276 . ? 1_555 ? 33 AC6 15 HOH H . ? HOH A 1300 . ? 1_555 ? 34 AC6 15 HOH H . ? HOH A 1349 . ? 1_555 ? # _database_PDB_matrix.entry_id 2ADD _database_PDB_matrix.origx[1][1] 1.000000 _database_PDB_matrix.origx[1][2] 0.000000 _database_PDB_matrix.origx[1][3] 0.000000 _database_PDB_matrix.origx[2][1] 0.000000 _database_PDB_matrix.origx[2][2] 1.000000 _database_PDB_matrix.origx[2][3] 0.000000 _database_PDB_matrix.origx[3][1] 0.000000 _database_PDB_matrix.origx[3][2] 0.000000 _database_PDB_matrix.origx[3][3] 1.000000 _database_PDB_matrix.origx_vector[1] 0.00000 _database_PDB_matrix.origx_vector[2] 0.00000 _database_PDB_matrix.origx_vector[3] 0.00000 # _atom_sites.entry_id 2ADD _atom_sites.fract_transf_matrix[1][1] 0.007178 _atom_sites.fract_transf_matrix[1][2] 0.000000 _atom_sites.fract_transf_matrix[1][3] 0.000000 _atom_sites.fract_transf_matrix[2][1] 0.000000 _atom_sites.fract_transf_matrix[2][2] 0.007178 _atom_sites.fract_transf_matrix[2][3] 0.000000 _atom_sites.fract_transf_matrix[3][1] 0.000000 _atom_sites.fract_transf_matrix[3][2] 0.000000 _atom_sites.fract_transf_matrix[3][3] 0.005472 _atom_sites.fract_transf_vector[1] 0.00000 _atom_sites.fract_transf_vector[2] 0.00000 _atom_sites.fract_transf_vector[3] 0.00000 # loop_ _atom_type.symbol C N O S # loop_ _atom_site.group_PDB _atom_site.id _atom_site.type_symbol _atom_site.label_atom_id _atom_site.label_alt_id _atom_site.label_comp_id _atom_site.label_asym_id _atom_site.label_entity_id _atom_site.label_seq_id _atom_site.pdbx_PDB_ins_code _atom_site.Cartn_x _atom_site.Cartn_y _atom_site.Cartn_z _atom_site.occupancy _atom_site.B_iso_or_equiv _atom_site.pdbx_formal_charge _atom_site.auth_seq_id _atom_site.auth_comp_id _atom_site.auth_asym_id _atom_site.auth_atom_id _atom_site.pdbx_PDB_model_num ATOM 1 N N . GLN A 1 2 ? 42.824 65.943 -12.499 1.00 60.29 ? 2 GLN A N 1 ATOM 2 C CA . GLN A 1 2 ? 41.439 66.498 -12.555 1.00 60.23 ? 2 GLN A CA 1 ATOM 3 C C . GLN A 1 2 ? 40.444 65.468 -13.094 1.00 58.43 ? 2 GLN A C 1 ATOM 4 O O . GLN A 1 2 ? 40.651 64.887 -14.160 1.00 58.54 ? 2 GLN A O 1 ATOM 5 C CB . GLN A 1 2 ? 41.411 67.750 -13.437 1.00 62.79 ? 2 GLN A CB 1 ATOM 6 C CG . GLN A 1 2 ? 40.024 68.357 -13.616 1.00 65.98 ? 2 GLN A CG 1 ATOM 7 C CD . GLN A 1 2 ? 39.487 68.999 -12.349 1.00 67.90 ? 2 GLN A CD 1 ATOM 8 O OE1 . GLN A 1 2 ? 39.478 68.386 -11.281 1.00 68.71 ? 2 GLN A OE1 1 ATOM 9 N NE2 . GLN A 1 2 ? 39.028 70.240 -12.466 1.00 69.05 ? 2 GLN A NE2 1 ATOM 10 N N . ILE A 1 3 ? 39.364 65.248 -12.349 1.00 55.72 ? 3 ILE A N 1 ATOM 11 C CA . ILE A 1 3 ? 38.335 64.289 -12.744 1.00 52.59 ? 3 ILE A CA 1 ATOM 12 C C . ILE A 1 3 ? 37.017 65.007 -13.026 1.00 50.49 ? 3 ILE A C 1 ATOM 13 O O . ILE A 1 3 ? 36.538 65.797 -12.214 1.00 49.57 ? 3 ILE A O 1 ATOM 14 C CB . ILE A 1 3 ? 38.139 63.223 -11.645 1.00 52.54 ? 3 ILE A CB 1 ATOM 15 C CG1 . ILE A 1 3 ? 39.448 62.448 -11.460 1.00 52.90 ? 3 ILE A CG1 1 ATOM 16 C CG2 . ILE A 1 3 ? 37.008 62.276 -12.016 1.00 50.48 ? 3 ILE A CG2 1 ATOM 17 C CD1 . ILE A 1 3 ? 39.430 61.441 -10.330 1.00 53.85 ? 3 ILE A CD1 1 ATOM 18 N N . GLU A 1 4 ? 36.440 64.727 -14.188 1.00 48.63 ? 4 GLU A N 1 ATOM 19 C CA . GLU A 1 4 ? 35.195 65.359 -14.611 1.00 48.46 ? 4 GLU A CA 1 ATOM 20 C C . GLU A 1 4 ? 33.956 64.877 -13.853 1.00 45.04 ? 4 GLU A C 1 ATOM 21 O O . GLU A 1 4 ? 33.729 63.672 -13.729 1.00 44.66 ? 4 GLU A O 1 ATOM 22 C CB . GLU A 1 4 ? 34.999 65.126 -16.114 1.00 53.12 ? 4 GLU A CB 1 ATOM 23 C CG . GLU A 1 4 ? 33.769 65.798 -16.712 1.00 60.50 ? 4 GLU A CG 1 ATOM 24 C CD . GLU A 1 4 ? 33.839 67.316 -16.654 1.00 65.13 ? 4 GLU A CD 1 ATOM 25 O OE1 . GLU A 1 4 ? 32.873 67.972 -17.108 1.00 67.70 ? 4 GLU A OE1 1 ATOM 26 O OE2 . GLU A 1 4 ? 34.857 67.854 -16.156 1.00 66.86 ? 4 GLU A OE2 1 ATOM 27 N N . GLN A 1 5 ? 33.161 65.824 -13.353 1.00 39.24 ? 5 GLN A N 1 ATOM 28 C CA . GLN A 1 5 ? 31.929 65.513 -12.624 1.00 35.94 ? 5 GLN A CA 1 ATOM 29 C C . GLN A 1 5 ? 32.077 64.370 -11.620 1.00 34.11 ? 5 GLN A C 1 ATOM 30 O O . GLN A 1 5 ? 31.369 63.364 -11.698 1.00 33.55 ? 5 GLN A O 1 ATOM 31 C CB . GLN A 1 5 ? 30.817 65.171 -13.620 1.00 34.87 ? 5 GLN A CB 1 ATOM 32 C CG . GLN A 1 5 ? 30.329 66.355 -14.435 1.00 34.30 ? 5 GLN A CG 1 ATOM 33 C CD . GLN A 1 5 ? 29.492 67.325 -13.613 1.00 35.98 ? 5 GLN A CD 1 ATOM 34 O OE1 . GLN A 1 5 ? 29.148 68.415 -14.078 1.00 34.86 ? 5 GLN A OE1 1 ATOM 35 N NE2 . GLN A 1 5 ? 29.153 66.929 -12.390 1.00 34.39 ? 5 GLN A NE2 1 ATOM 36 N N . PRO A 1 6 ? 32.983 64.524 -10.644 1.00 32.39 ? 6 PRO A N 1 ATOM 37 C CA . PRO A 1 6 ? 33.225 63.500 -9.624 1.00 31.13 ? 6 PRO A CA 1 ATOM 38 C C . PRO A 1 6 ? 32.037 63.173 -8.715 1.00 30.71 ? 6 PRO A C 1 ATOM 39 O O . PRO A 1 6 ? 32.039 62.141 -8.043 1.00 31.47 ? 6 PRO A O 1 ATOM 40 C CB . PRO A 1 6 ? 34.400 64.075 -8.844 1.00 30.71 ? 6 PRO A CB 1 ATOM 41 C CG . PRO A 1 6 ? 34.132 65.547 -8.911 1.00 30.65 ? 6 PRO A CG 1 ATOM 42 C CD . PRO A 1 6 ? 33.762 65.743 -10.354 1.00 30.35 ? 6 PRO A CD 1 ATOM 43 N N . TYR A 1 7 ? 31.027 64.040 -8.697 1.00 29.32 ? 7 TYR A N 1 ATOM 44 C CA . TYR A 1 7 ? 29.864 63.821 -7.841 1.00 28.02 ? 7 TYR A CA 1 ATOM 45 C C . TYR A 1 7 ? 28.675 63.138 -8.511 1.00 27.81 ? 7 TYR A C 1 ATOM 46 O O . TYR A 1 7 ? 27.719 62.759 -7.832 1.00 27.07 ? 7 TYR A O 1 ATOM 47 C CB . TYR A 1 7 ? 29.418 65.144 -7.211 1.00 26.98 ? 7 TYR A CB 1 ATOM 48 C CG . TYR A 1 7 ? 30.500 65.780 -6.373 1.00 27.82 ? 7 TYR A CG 1 ATOM 49 C CD1 . TYR A 1 7 ? 31.103 65.074 -5.333 1.00 26.73 ? 7 TYR A CD1 1 ATOM 50 C CD2 . TYR A 1 7 ? 30.945 67.076 -6.636 1.00 26.78 ? 7 TYR A CD2 1 ATOM 51 C CE1 . TYR A 1 7 ? 32.125 65.639 -4.576 1.00 27.73 ? 7 TYR A CE1 1 ATOM 52 C CE2 . TYR A 1 7 ? 31.970 67.653 -5.885 1.00 27.38 ? 7 TYR A CE2 1 ATOM 53 C CZ . TYR A 1 7 ? 32.556 66.928 -4.858 1.00 28.15 ? 7 TYR A CZ 1 ATOM 54 O OH . TYR A 1 7 ? 33.581 67.478 -4.122 1.00 27.96 ? 7 TYR A OH 1 ATOM 55 N N . ARG A 1 8 ? 28.719 62.982 -9.831 1.00 26.41 ? 8 ARG A N 1 ATOM 56 C CA . ARG A 1 8 ? 27.630 62.299 -10.516 1.00 26.02 ? 8 ARG A CA 1 ATOM 57 C C . ARG A 1 8 ? 27.737 60.822 -10.157 1.00 25.34 ? 8 ARG A C 1 ATOM 58 O O . ARG A 1 8 ? 28.839 60.298 -9.994 1.00 25.06 ? 8 ARG A O 1 ATOM 59 C CB . ARG A 1 8 ? 27.730 62.474 -12.035 1.00 24.49 ? 8 ARG A CB 1 ATOM 60 C CG . ARG A 1 8 ? 27.397 63.879 -12.526 1.00 25.90 ? 8 ARG A CG 1 ATOM 61 C CD . ARG A 1 8 ? 27.292 63.928 -14.048 1.00 24.29 ? 8 ARG A CD 1 ATOM 62 N NE . ARG A 1 8 ? 26.126 63.203 -14.546 1.00 24.59 ? 8 ARG A NE 1 ATOM 63 C CZ . ARG A 1 8 ? 24.874 63.647 -14.468 1.00 26.00 ? 8 ARG A CZ 1 ATOM 64 N NH1 . ARG A 1 8 ? 24.620 64.827 -13.913 1.00 25.36 ? 8 ARG A NH1 1 ATOM 65 N NH2 . ARG A 1 8 ? 23.874 62.909 -14.937 1.00 23.83 ? 8 ARG A NH2 1 ATOM 66 N N . THR A 1 9 ? 26.598 60.149 -10.030 1.00 24.82 ? 9 THR A N 1 ATOM 67 C CA . THR A 1 9 ? 26.607 58.736 -9.676 1.00 22.92 ? 9 THR A CA 1 ATOM 68 C C . THR A 1 9 ? 26.761 57.862 -10.911 1.00 22.71 ? 9 THR A C 1 ATOM 69 O O . THR A 1 9 ? 26.512 58.303 -12.036 1.00 22.54 ? 9 THR A O 1 ATOM 70 C CB . THR A 1 9 ? 25.309 58.333 -8.958 1.00 23.68 ? 9 THR A CB 1 ATOM 71 O OG1 . THR A 1 9 ? 24.223 58.358 -9.892 1.00 22.89 ? 9 THR A OG1 1 ATOM 72 C CG2 . THR A 1 9 ? 25.014 59.295 -7.808 1.00 19.75 ? 9 THR A CG2 1 ATOM 73 N N . GLY A 1 10 ? 27.168 56.616 -10.691 1.00 22.05 ? 10 GLY A N 1 ATOM 74 C CA . GLY A 1 10 ? 27.349 55.691 -11.791 1.00 19.71 ? 10 GLY A CA 1 ATOM 75 C C . GLY A 1 10 ? 26.178 54.742 -11.979 1.00 21.60 ? 10 GLY A C 1 ATOM 76 O O . GLY A 1 10 ? 25.997 54.192 -13.070 1.00 21.70 ? 10 GLY A O 1 ATOM 77 N N . TYR A 1 11 ? 25.379 54.534 -10.934 1.00 19.74 ? 11 TYR A N 1 ATOM 78 C CA . TYR A 1 11 ? 24.244 53.629 -11.061 1.00 20.11 ? 11 TYR A CA 1 ATOM 79 C C . TYR A 1 11 ? 22.953 54.074 -10.368 1.00 20.25 ? 11 TYR A C 1 ATOM 80 O O . TYR A 1 11 ? 22.069 53.260 -10.095 1.00 21.53 ? 11 TYR A O 1 ATOM 81 C CB . TYR A 1 11 ? 24.644 52.208 -10.620 1.00 18.89 ? 11 TYR A CB 1 ATOM 82 C CG . TYR A 1 11 ? 25.127 52.072 -9.191 1.00 19.83 ? 11 TYR A CG 1 ATOM 83 C CD1 . TYR A 1 11 ? 24.228 51.856 -8.141 1.00 20.05 ? 11 TYR A CD1 1 ATOM 84 C CD2 . TYR A 1 11 ? 26.486 52.142 -8.888 1.00 18.93 ? 11 TYR A CD2 1 ATOM 85 C CE1 . TYR A 1 11 ? 24.674 51.712 -6.820 1.00 20.24 ? 11 TYR A CE1 1 ATOM 86 C CE2 . TYR A 1 11 ? 26.945 52.000 -7.579 1.00 18.10 ? 11 TYR A CE2 1 ATOM 87 C CZ . TYR A 1 11 ? 26.038 51.787 -6.548 1.00 21.39 ? 11 TYR A CZ 1 ATOM 88 O OH . TYR A 1 11 ? 26.496 51.665 -5.248 1.00 20.03 ? 11 TYR A OH 1 ATOM 89 N N . HIS A 1 12 ? 22.847 55.368 -10.086 1.00 19.10 ? 12 HIS A N 1 ATOM 90 C CA . HIS A 1 12 ? 21.637 55.914 -9.483 1.00 19.29 ? 12 HIS A CA 1 ATOM 91 C C . HIS A 1 12 ? 20.922 56.713 -10.555 1.00 20.17 ? 12 HIS A C 1 ATOM 92 O O . HIS A 1 12 ? 21.564 57.292 -11.439 1.00 20.09 ? 12 HIS A O 1 ATOM 93 C CB . HIS A 1 12 ? 21.958 56.837 -8.314 1.00 17.67 ? 12 HIS A CB 1 ATOM 94 C CG . HIS A 1 12 ? 22.195 56.116 -7.027 1.00 18.22 ? 12 HIS A CG 1 ATOM 95 N ND1 . HIS A 1 12 ? 23.354 55.417 -6.768 1.00 18.06 ? 12 HIS A ND1 1 ATOM 96 C CD2 . HIS A 1 12 ? 21.413 55.970 -5.932 1.00 16.56 ? 12 HIS A CD2 1 ATOM 97 C CE1 . HIS A 1 12 ? 23.276 54.874 -5.567 1.00 18.44 ? 12 HIS A CE1 1 ATOM 98 N NE2 . HIS A 1 12 ? 22.109 55.194 -5.039 1.00 16.39 ? 12 HIS A NE2 1 ATOM 99 N N . PHE A 1 13 ? 19.600 56.759 -10.492 1.00 20.05 ? 13 PHE A N 1 ATOM 100 C CA . PHE A 1 13 ? 18.887 57.514 -11.503 1.00 21.06 ? 13 PHE A CA 1 ATOM 101 C C . PHE A 1 13 ? 19.003 59.011 -11.291 1.00 22.10 ? 13 PHE A C 1 ATOM 102 O O . PHE A 1 13 ? 18.853 59.509 -10.178 1.00 23.06 ? 13 PHE A O 1 ATOM 103 C CB . PHE A 1 13 ? 17.402 57.166 -11.544 1.00 20.43 ? 13 PHE A CB 1 ATOM 104 C CG . PHE A 1 13 ? 16.674 57.857 -12.660 1.00 21.85 ? 13 PHE A CG 1 ATOM 105 C CD1 . PHE A 1 13 ? 16.587 57.266 -13.918 1.00 23.35 ? 13 PHE A CD1 1 ATOM 106 C CD2 . PHE A 1 13 ? 16.166 59.144 -12.486 1.00 20.42 ? 13 PHE A CD2 1 ATOM 107 C CE1 . PHE A 1 13 ? 16.010 57.948 -14.988 1.00 23.20 ? 13 PHE A CE1 1 ATOM 108 C CE2 . PHE A 1 13 ? 15.590 59.835 -13.545 1.00 20.47 ? 13 PHE A CE2 1 ATOM 109 C CZ . PHE A 1 13 ? 15.512 59.237 -14.801 1.00 23.63 ? 13 PHE A CZ 1 ATOM 110 N N . GLN A 1 14 ? 19.264 59.719 -12.382 1.00 22.75 ? 14 GLN A N 1 ATOM 111 C CA . GLN A 1 14 ? 19.356 61.172 -12.382 1.00 22.60 ? 14 GLN A CA 1 ATOM 112 C C . GLN A 1 14 ? 19.328 61.599 -13.843 1.00 22.87 ? 14 GLN A C 1 ATOM 113 O O . GLN A 1 14 ? 19.771 60.858 -14.723 1.00 21.50 ? 14 GLN A O 1 ATOM 114 C CB . GLN A 1 14 ? 20.634 61.662 -11.674 1.00 21.13 ? 14 GLN A CB 1 ATOM 115 C CG . GLN A 1 14 ? 21.961 61.217 -12.276 1.00 20.76 ? 14 GLN A CG 1 ATOM 116 C CD . GLN A 1 14 ? 23.154 61.636 -11.413 1.00 24.29 ? 14 GLN A CD 1 ATOM 117 O OE1 . GLN A 1 14 ? 23.865 60.788 -10.849 1.00 23.17 ? 14 GLN A OE1 1 ATOM 118 N NE2 . GLN A 1 14 ? 23.374 62.950 -11.299 1.00 18.44 ? 14 GLN A NE2 1 ATOM 119 N N . PRO A 1 15 ? 18.773 62.785 -14.128 1.00 23.28 ? 15 PRO A N 1 ATOM 120 C CA . PRO A 1 15 ? 18.707 63.261 -15.512 1.00 23.63 ? 15 PRO A CA 1 ATOM 121 C C . PRO A 1 15 ? 20.083 63.649 -16.028 1.00 23.41 ? 15 PRO A C 1 ATOM 122 O O . PRO A 1 15 ? 21.025 63.785 -15.248 1.00 23.90 ? 15 PRO A O 1 ATOM 123 C CB . PRO A 1 15 ? 17.763 64.455 -15.414 1.00 24.25 ? 15 PRO A CB 1 ATOM 124 C CG . PRO A 1 15 ? 18.083 65.011 -14.052 1.00 23.96 ? 15 PRO A CG 1 ATOM 125 C CD . PRO A 1 15 ? 18.169 63.762 -13.200 1.00 23.70 ? 15 PRO A CD 1 ATOM 126 N N . PRO A 1 16 ? 20.225 63.810 -17.354 1.00 24.44 ? 16 PRO A N 1 ATOM 127 C CA . PRO A 1 16 ? 21.523 64.192 -17.924 1.00 23.93 ? 16 PRO A CA 1 ATOM 128 C C . PRO A 1 16 ? 22.067 65.426 -17.205 1.00 25.01 ? 16 PRO A C 1 ATOM 129 O O . PRO A 1 16 ? 23.275 65.550 -16.980 1.00 25.69 ? 16 PRO A O 1 ATOM 130 C CB . PRO A 1 16 ? 21.186 64.460 -19.387 1.00 21.67 ? 16 PRO A CB 1 ATOM 131 C CG . PRO A 1 16 ? 20.124 63.434 -19.659 1.00 23.28 ? 16 PRO A CG 1 ATOM 132 C CD . PRO A 1 16 ? 19.241 63.543 -18.419 1.00 24.09 ? 16 PRO A CD 1 ATOM 133 N N . SER A 1 17 ? 21.164 66.333 -16.838 1.00 24.29 ? 17 SER A N 1 ATOM 134 C CA . SER A 1 17 ? 21.546 67.542 -16.121 1.00 26.72 ? 17 SER A CA 1 ATOM 135 C C . SER A 1 17 ? 20.330 68.254 -15.532 1.00 26.51 ? 17 SER A C 1 ATOM 136 O O . SER A 1 17 ? 19.195 67.795 -15.670 1.00 26.22 ? 17 SER A O 1 ATOM 137 C CB . SER A 1 17 ? 22.290 68.503 -17.048 1.00 26.90 ? 17 SER A CB 1 ATOM 138 O OG . SER A 1 17 ? 21.384 69.134 -17.931 1.00 30.48 ? 17 SER A OG 1 ATOM 139 N N . ASN A 1 18 ? 20.592 69.378 -14.873 1.00 25.87 ? 18 ASN A N 1 ATOM 140 C CA . ASN A 1 18 ? 19.565 70.206 -14.247 1.00 25.97 ? 18 ASN A CA 1 ATOM 141 C C . ASN A 1 18 ? 18.965 69.667 -12.960 1.00 26.05 ? 18 ASN A C 1 ATOM 142 O O . ASN A 1 18 ? 19.438 68.681 -12.391 1.00 26.17 ? 18 ASN A O 1 ATOM 143 C CB . ASN A 1 18 ? 18.443 70.519 -15.235 1.00 27.32 ? 18 ASN A CB 1 ATOM 144 C CG . ASN A 1 18 ? 18.918 71.367 -16.392 1.00 30.46 ? 18 ASN A CG 1 ATOM 145 O OD1 . ASN A 1 18 ? 19.613 72.364 -16.199 1.00 34.12 ? 18 ASN A OD1 1 ATOM 146 N ND2 . ASN A 1 18 ? 18.546 70.979 -17.602 1.00 31.26 ? 18 ASN A ND2 1 ATOM 147 N N . TRP A 1 19 ? 17.910 70.339 -12.514 1.00 24.05 ? 19 TRP A N 1 ATOM 148 C CA . TRP A 1 19 ? 17.231 70.002 -11.280 1.00 23.44 ? 19 TRP A CA 1 ATOM 149 C C . TRP A 1 19 ? 16.139 68.951 -11.380 1.00 24.38 ? 19 TRP A C 1 ATOM 150 O O . TRP A 1 19 ? 15.323 68.952 -12.306 1.00 24.28 ? 19 TRP A O 1 ATOM 151 C CB . TRP A 1 19 ? 16.649 71.274 -10.660 1.00 21.49 ? 19 TRP A CB 1 ATOM 152 C CG . TRP A 1 19 ? 15.673 71.036 -9.544 1.00 20.73 ? 19 TRP A CG 1 ATOM 153 C CD1 . TRP A 1 19 ? 14.391 70.563 -9.653 1.00 20.61 ? 19 TRP A CD1 1 ATOM 154 C CD2 . TRP A 1 19 ? 15.891 71.286 -8.149 1.00 19.93 ? 19 TRP A CD2 1 ATOM 155 N NE1 . TRP A 1 19 ? 13.798 70.509 -8.410 1.00 21.27 ? 19 TRP A NE1 1 ATOM 156 C CE2 . TRP A 1 19 ? 14.696 70.947 -7.471 1.00 20.39 ? 19 TRP A CE2 1 ATOM 157 C CE3 . TRP A 1 19 ? 16.979 71.768 -7.406 1.00 19.90 ? 19 TRP A CE3 1 ATOM 158 C CZ2 . TRP A 1 19 ? 14.559 71.076 -6.083 1.00 20.92 ? 19 TRP A CZ2 1 ATOM 159 C CZ3 . TRP A 1 19 ? 16.843 71.897 -6.024 1.00 17.84 ? 19 TRP A CZ3 1 ATOM 160 C CH2 . TRP A 1 19 ? 15.640 71.552 -5.380 1.00 20.62 ? 19 TRP A CH2 1 ATOM 161 N N . MET A 1 20 ? 16.135 68.066 -10.389 1.00 23.49 ? 20 MET A N 1 ATOM 162 C CA . MET A 1 20 ? 15.149 67.003 -10.279 1.00 22.43 ? 20 MET A CA 1 ATOM 163 C C . MET A 1 20 ? 14.795 66.792 -8.816 1.00 22.19 ? 20 MET A C 1 ATOM 164 O O . MET A 1 20 ? 15.684 66.733 -7.967 1.00 21.65 ? 20 MET A O 1 ATOM 165 C CB . MET A 1 20 ? 15.689 65.672 -10.821 1.00 18.27 ? 20 MET A CB 1 ATOM 166 C CG . MET A 1 20 ? 14.891 64.465 -10.295 1.00 18.17 ? 20 MET A CG 1 ATOM 167 S SD . MET A 1 20 ? 15.418 62.805 -10.807 1.00 20.52 ? 20 MET A SD 1 ATOM 168 C CE . MET A 1 20 ? 16.925 62.597 -9.822 1.00 18.94 ? 20 MET A CE 1 ATOM 169 N N . ASN A 1 21 ? 13.505 66.713 -8.509 1.00 22.13 ? 21 ASN A N 1 ATOM 170 C CA . ASN A 1 21 ? 13.125 66.404 -7.145 1.00 22.51 ? 21 ASN A CA 1 ATOM 171 C C . ASN A 1 21 ? 12.195 65.180 -7.085 1.00 22.75 ? 21 ASN A C 1 ATOM 172 O O . ASN A 1 21 ? 12.610 64.083 -7.467 1.00 22.96 ? 21 ASN A O 1 ATOM 173 C CB . ASN A 1 21 ? 12.571 67.634 -6.365 1.00 24.10 ? 21 ASN A CB 1 ATOM 174 C CG . ASN A 1 21 ? 11.410 68.348 -7.053 1.00 24.63 ? 21 ASN A CG 1 ATOM 175 O OD1 . ASN A 1 21 ? 11.545 68.877 -8.155 1.00 25.14 ? 21 ASN A OD1 1 ATOM 176 N ND2 . ASN A 1 21 ? 10.265 68.394 -6.375 1.00 23.49 ? 21 ASN A ND2 1 ATOM 177 N N . ASP A 1 22 ? 10.956 65.354 -6.646 1.00 21.24 ? 22 ASP A N 1 ATOM 178 C CA . ASP A 1 22 ? 10.009 64.244 -6.474 1.00 21.78 ? 22 ASP A CA 1 ATOM 179 C C . ASP A 1 22 ? 9.766 63.187 -7.566 1.00 22.25 ? 22 ASP A C 1 ATOM 180 O O . ASP A 1 22 ? 9.526 63.511 -8.732 1.00 23.25 ? 22 ASP A O 1 ATOM 181 C CB . ASP A 1 22 ? 8.648 64.813 -6.073 1.00 22.83 ? 22 ASP A CB 1 ATOM 182 C CG . ASP A 1 22 ? 8.717 65.672 -4.830 1.00 24.64 ? 22 ASP A CG 1 ATOM 183 O OD1 . ASP A 1 22 ? 9.828 66.128 -4.470 1.00 23.73 ? 22 ASP A OD1 1 ATOM 184 O OD2 . ASP A 1 22 ? 7.650 65.903 -4.222 1.00 25.40 ? 22 ASP A OD2 1 ATOM 185 N N . PRO A 1 23 ? 9.819 61.895 -7.189 1.00 22.22 ? 23 PRO A N 1 ATOM 186 C CA . PRO A 1 23 ? 9.575 60.824 -8.163 1.00 21.07 ? 23 PRO A CA 1 ATOM 187 C C . PRO A 1 23 ? 8.070 60.857 -8.460 1.00 21.77 ? 23 PRO A C 1 ATOM 188 O O . PRO A 1 23 ? 7.260 61.037 -7.544 1.00 20.96 ? 23 PRO A O 1 ATOM 189 C CB . PRO A 1 23 ? 9.987 59.563 -7.403 1.00 20.79 ? 23 PRO A CB 1 ATOM 190 C CG . PRO A 1 23 ? 9.676 59.920 -5.966 1.00 19.40 ? 23 PRO A CG 1 ATOM 191 C CD . PRO A 1 23 ? 10.206 61.337 -5.879 1.00 20.48 ? 23 PRO A CD 1 ATOM 192 N N . ASN A 1 24 ? 7.690 60.689 -9.723 1.00 20.83 ? 24 ASN A N 1 ATOM 193 C CA . ASN A 1 24 ? 6.278 60.736 -10.092 1.00 21.24 ? 24 ASN A CA 1 ATOM 194 C C . ASN A 1 24 ? 5.807 59.532 -10.899 1.00 21.83 ? 24 ASN A C 1 ATOM 195 O O . ASN A 1 24 ? 6.575 58.921 -11.644 1.00 22.18 ? 24 ASN A O 1 ATOM 196 C CB . ASN A 1 24 ? 5.992 61.998 -10.917 1.00 21.86 ? 24 ASN A CB 1 ATOM 197 C CG . ASN A 1 24 ? 6.217 63.288 -10.139 1.00 22.81 ? 24 ASN A CG 1 ATOM 198 O OD1 . ASN A 1 24 ? 6.486 64.330 -10.734 1.00 22.69 ? 24 ASN A OD1 1 ATOM 199 N ND2 . ASN A 1 24 ? 6.088 63.231 -8.813 1.00 21.88 ? 24 ASN A ND2 1 ATOM 200 N N . GLY A 1 25 ? 4.526 59.216 -10.741 1.00 20.95 ? 25 GLY A N 1 ATOM 201 C CA . GLY A 1 25 ? 3.895 58.122 -11.462 1.00 20.50 ? 25 GLY A CA 1 ATOM 202 C C . GLY A 1 25 ? 4.655 56.842 -11.766 1.00 20.96 ? 25 GLY A C 1 ATOM 203 O O . GLY A 1 25 ? 4.481 56.284 -12.852 1.00 22.20 ? 25 GLY A O 1 ATOM 204 N N . PRO A 1 26 ? 5.494 56.336 -10.851 1.00 18.73 ? 26 PRO A N 1 ATOM 205 C CA . PRO A 1 26 ? 6.192 55.095 -11.199 1.00 18.45 ? 26 PRO A CA 1 ATOM 206 C C . PRO A 1 26 ? 5.184 53.971 -11.427 1.00 19.49 ? 26 PRO A C 1 ATOM 207 O O . PRO A 1 26 ? 4.123 53.947 -10.799 1.00 17.86 ? 26 PRO A O 1 ATOM 208 C CB . PRO A 1 26 ? 7.076 54.839 -9.981 1.00 18.23 ? 26 PRO A CB 1 ATOM 209 C CG . PRO A 1 26 ? 6.283 55.445 -8.854 1.00 17.91 ? 26 PRO A CG 1 ATOM 210 C CD . PRO A 1 26 ? 5.785 56.742 -9.465 1.00 17.82 ? 26 PRO A CD 1 ATOM 211 N N . MET A 1 27 ? 5.517 53.044 -12.322 1.00 20.77 ? 27 MET A N 1 ATOM 212 C CA . MET A 1 27 ? 4.629 51.925 -12.621 1.00 21.22 ? 27 MET A CA 1 ATOM 213 C C . MET A 1 27 ? 5.289 50.936 -13.578 1.00 22.29 ? 27 MET A C 1 ATOM 214 O O . MET A 1 27 ? 6.332 51.221 -14.169 1.00 23.69 ? 27 MET A O 1 ATOM 215 C CB . MET A 1 27 ? 3.340 52.437 -13.274 1.00 20.93 ? 27 MET A CB 1 ATOM 216 C CG . MET A 1 27 ? 3.578 53.059 -14.657 1.00 21.83 ? 27 MET A CG 1 ATOM 217 S SD . MET A 1 27 ? 2.077 53.356 -15.638 1.00 23.67 ? 27 MET A SD 1 ATOM 218 C CE . MET A 1 27 ? 2.703 54.462 -16.905 1.00 19.96 ? 27 MET A CE 1 ATOM 219 N N . LEU A 1 28 ? 4.667 49.771 -13.715 1.00 22.07 ? 28 LEU A N 1 ATOM 220 C CA . LEU A 1 28 ? 5.122 48.741 -14.637 1.00 22.52 ? 28 LEU A CA 1 ATOM 221 C C . LEU A 1 28 ? 3.962 48.566 -15.614 1.00 23.54 ? 28 LEU A C 1 ATOM 222 O O . LEU A 1 28 ? 2.844 48.250 -15.206 1.00 24.58 ? 28 LEU A O 1 ATOM 223 C CB . LEU A 1 28 ? 5.382 47.416 -13.915 1.00 21.59 ? 28 LEU A CB 1 ATOM 224 C CG . LEU A 1 28 ? 5.575 46.210 -14.852 1.00 21.65 ? 28 LEU A CG 1 ATOM 225 C CD1 . LEU A 1 28 ? 6.832 46.399 -15.689 1.00 20.87 ? 28 LEU A CD1 1 ATOM 226 C CD2 . LEU A 1 28 ? 5.677 44.932 -14.047 1.00 20.10 ? 28 LEU A CD2 1 ATOM 227 N N . TYR A 1 29 ? 4.218 48.786 -16.897 1.00 24.42 ? 29 TYR A N 1 ATOM 228 C CA . TYR A 1 29 ? 3.170 48.649 -17.901 1.00 24.17 ? 29 TYR A CA 1 ATOM 229 C C . TYR A 1 29 ? 3.684 47.913 -19.124 1.00 24.46 ? 29 TYR A C 1 ATOM 230 O O . TYR A 1 29 ? 4.677 48.319 -19.726 1.00 24.67 ? 29 TYR A O 1 ATOM 231 C CB . TYR A 1 29 ? 2.656 50.026 -18.323 1.00 24.28 ? 29 TYR A CB 1 ATOM 232 C CG . TYR A 1 29 ? 1.464 49.971 -19.251 1.00 24.21 ? 29 TYR A CG 1 ATOM 233 C CD1 . TYR A 1 29 ? 0.218 49.541 -18.792 1.00 22.28 ? 29 TYR A CD1 1 ATOM 234 C CD2 . TYR A 1 29 ? 1.584 50.337 -20.595 1.00 24.15 ? 29 TYR A CD2 1 ATOM 235 C CE1 . TYR A 1 29 ? -0.883 49.475 -19.649 1.00 22.98 ? 29 TYR A CE1 1 ATOM 236 C CE2 . TYR A 1 29 ? 0.491 50.276 -21.460 1.00 23.42 ? 29 TYR A CE2 1 ATOM 237 C CZ . TYR A 1 29 ? -0.738 49.844 -20.982 1.00 24.48 ? 29 TYR A CZ 1 ATOM 238 O OH . TYR A 1 29 ? -1.816 49.782 -21.834 1.00 25.20 ? 29 TYR A OH 1 ATOM 239 N N . GLN A 1 30 ? 3.009 46.825 -19.478 1.00 25.31 ? 30 GLN A N 1 ATOM 240 C CA . GLN A 1 30 ? 3.382 46.034 -20.643 1.00 25.24 ? 30 GLN A CA 1 ATOM 241 C C . GLN A 1 30 ? 4.870 45.707 -20.683 1.00 24.70 ? 30 GLN A C 1 ATOM 242 O O . GLN A 1 30 ? 5.536 45.929 -21.695 1.00 24.07 ? 30 GLN A O 1 ATOM 243 C CB . GLN A 1 30 ? 2.987 46.783 -21.918 1.00 28.36 ? 30 GLN A CB 1 ATOM 244 C CG . GLN A 1 30 ? 1.489 47.038 -22.047 1.00 32.19 ? 30 GLN A CG 1 ATOM 245 C CD . GLN A 1 30 ? 0.695 45.769 -22.322 1.00 34.72 ? 30 GLN A CD 1 ATOM 246 O OE1 . GLN A 1 30 ? 0.679 44.839 -21.517 1.00 36.25 ? 30 GLN A OE1 1 ATOM 247 N NE2 . GLN A 1 30 ? 0.032 45.730 -23.469 1.00 35.12 ? 30 GLN A NE2 1 ATOM 248 N N . GLY A 1 31 ? 5.388 45.192 -19.573 1.00 24.50 ? 31 GLY A N 1 ATOM 249 C CA . GLY A 1 31 ? 6.788 44.811 -19.507 1.00 23.39 ? 31 GLY A CA 1 ATOM 250 C C . GLY A 1 31 ? 7.794 45.935 -19.362 1.00 24.80 ? 31 GLY A C 1 ATOM 251 O O . GLY A 1 31 ? 8.991 45.675 -19.243 1.00 26.25 ? 31 GLY A O 1 ATOM 252 N N . VAL A 1 32 ? 7.329 47.179 -19.361 1.00 23.88 ? 32 VAL A N 1 ATOM 253 C CA . VAL A 1 32 ? 8.236 48.315 -19.240 1.00 22.89 ? 32 VAL A CA 1 ATOM 254 C C . VAL A 1 32 ? 8.043 49.087 -17.934 1.00 22.95 ? 32 VAL A C 1 ATOM 255 O O . VAL A 1 32 ? 6.915 49.409 -17.552 1.00 23.35 ? 32 VAL A O 1 ATOM 256 C CB . VAL A 1 32 ? 8.040 49.297 -20.417 1.00 24.44 ? 32 VAL A CB 1 ATOM 257 C CG1 . VAL A 1 32 ? 8.995 50.472 -20.285 1.00 23.76 ? 32 VAL A CG1 1 ATOM 258 C CG2 . VAL A 1 32 ? 8.256 48.576 -21.741 1.00 24.40 ? 32 VAL A CG2 1 ATOM 259 N N . TYR A 1 33 ? 9.144 49.365 -17.243 1.00 21.10 ? 33 TYR A N 1 ATOM 260 C CA . TYR A 1 33 ? 9.084 50.140 -16.006 1.00 21.58 ? 33 TYR A CA 1 ATOM 261 C C . TYR A 1 33 ? 9.157 51.612 -16.401 1.00 21.10 ? 33 TYR A C 1 ATOM 262 O O . TYR A 1 33 ? 10.076 52.023 -17.118 1.00 21.29 ? 33 TYR A O 1 ATOM 263 C CB . TYR A 1 33 ? 10.267 49.809 -15.090 1.00 20.18 ? 33 TYR A CB 1 ATOM 264 C CG . TYR A 1 33 ? 10.199 48.445 -14.454 1.00 20.21 ? 33 TYR A CG 1 ATOM 265 C CD1 . TYR A 1 33 ? 9.360 48.201 -13.365 1.00 19.14 ? 33 TYR A CD1 1 ATOM 266 C CD2 . TYR A 1 33 ? 10.963 47.387 -14.948 1.00 19.83 ? 33 TYR A CD2 1 ATOM 267 C CE1 . TYR A 1 33 ? 9.285 46.936 -12.784 1.00 18.32 ? 33 TYR A CE1 1 ATOM 268 C CE2 . TYR A 1 33 ? 10.895 46.119 -14.377 1.00 17.82 ? 33 TYR A CE2 1 ATOM 269 C CZ . TYR A 1 33 ? 10.056 45.899 -13.299 1.00 18.79 ? 33 TYR A CZ 1 ATOM 270 O OH . TYR A 1 33 ? 9.978 44.635 -12.755 1.00 19.80 ? 33 TYR A OH 1 ATOM 271 N N . HIS A 1 34 ? 8.186 52.399 -15.952 1.00 19.64 ? 34 HIS A N 1 ATOM 272 C CA . HIS A 1 34 ? 8.172 53.823 -16.259 1.00 18.58 ? 34 HIS A CA 1 ATOM 273 C C . HIS A 1 34 ? 8.527 54.627 -15.022 1.00 19.59 ? 34 HIS A C 1 ATOM 274 O O . HIS A 1 34 ? 8.103 54.296 -13.911 1.00 19.34 ? 34 HIS A O 1 ATOM 275 C CB . HIS A 1 34 ? 6.788 54.255 -16.744 1.00 18.32 ? 34 HIS A CB 1 ATOM 276 C CG . HIS A 1 34 ? 6.449 53.773 -18.120 1.00 20.63 ? 34 HIS A CG 1 ATOM 277 N ND1 . HIS A 1 34 ? 6.655 54.538 -19.249 1.00 20.01 ? 34 HIS A ND1 1 ATOM 278 C CD2 . HIS A 1 34 ? 5.949 52.591 -18.552 1.00 19.44 ? 34 HIS A CD2 1 ATOM 279 C CE1 . HIS A 1 34 ? 6.296 53.848 -20.317 1.00 20.20 ? 34 HIS A CE1 1 ATOM 280 N NE2 . HIS A 1 34 ? 5.865 52.664 -19.922 1.00 21.96 ? 34 HIS A NE2 1 ATOM 281 N N . PHE A 1 35 ? 9.321 55.674 -15.216 1.00 19.17 ? 35 PHE A N 1 ATOM 282 C CA . PHE A 1 35 ? 9.689 56.555 -14.122 1.00 18.49 ? 35 PHE A CA 1 ATOM 283 C C . PHE A 1 35 ? 9.536 58.001 -14.577 1.00 19.99 ? 35 PHE A C 1 ATOM 284 O O . PHE A 1 35 ? 9.978 58.374 -15.665 1.00 20.44 ? 35 PHE A O 1 ATOM 285 C CB . PHE A 1 35 ? 11.127 56.320 -13.660 1.00 17.84 ? 35 PHE A CB 1 ATOM 286 C CG . PHE A 1 35 ? 11.512 57.165 -12.475 1.00 17.27 ? 35 PHE A CG 1 ATOM 287 C CD1 . PHE A 1 35 ? 10.910 56.956 -11.236 1.00 17.07 ? 35 PHE A CD1 1 ATOM 288 C CD2 . PHE A 1 35 ? 12.435 58.202 -12.608 1.00 17.55 ? 35 PHE A CD2 1 ATOM 289 C CE1 . PHE A 1 35 ? 11.212 57.767 -10.146 1.00 15.88 ? 35 PHE A CE1 1 ATOM 290 C CE2 . PHE A 1 35 ? 12.746 59.022 -11.524 1.00 17.74 ? 35 PHE A CE2 1 ATOM 291 C CZ . PHE A 1 35 ? 12.130 58.802 -10.288 1.00 17.83 ? 35 PHE A CZ 1 ATOM 292 N N . PHE A 1 36 ? 8.896 58.805 -13.736 1.00 19.75 ? 36 PHE A N 1 ATOM 293 C CA . PHE A 1 36 ? 8.673 60.214 -14.019 1.00 19.52 ? 36 PHE A CA 1 ATOM 294 C C . PHE A 1 36 ? 9.237 60.969 -12.826 1.00 22.11 ? 36 PHE A C 1 ATOM 295 O O . PHE A 1 36 ? 9.463 60.379 -11.768 1.00 22.13 ? 36 PHE A O 1 ATOM 296 C CB . PHE A 1 36 ? 7.177 60.487 -14.153 1.00 18.18 ? 36 PHE A CB 1 ATOM 297 C CG . PHE A 1 36 ? 6.498 59.644 -15.200 1.00 18.61 ? 36 PHE A CG 1 ATOM 298 C CD1 . PHE A 1 36 ? 6.484 60.042 -16.532 1.00 16.85 ? 36 PHE A CD1 1 ATOM 299 C CD2 . PHE A 1 36 ? 5.874 58.444 -14.850 1.00 16.76 ? 36 PHE A CD2 1 ATOM 300 C CE1 . PHE A 1 36 ? 5.854 59.257 -17.505 1.00 18.89 ? 36 PHE A CE1 1 ATOM 301 C CE2 . PHE A 1 36 ? 5.245 57.655 -15.812 1.00 17.93 ? 36 PHE A CE2 1 ATOM 302 C CZ . PHE A 1 36 ? 5.233 58.063 -17.143 1.00 17.44 ? 36 PHE A CZ 1 ATOM 303 N N . TYR A 1 37 ? 9.464 62.267 -12.982 1.00 21.33 ? 37 TYR A N 1 ATOM 304 C CA . TYR A 1 37 ? 10.015 63.042 -11.884 1.00 21.80 ? 37 TYR A CA 1 ATOM 305 C C . TYR A 1 37 ? 9.905 64.541 -12.106 1.00 22.76 ? 37 TYR A C 1 ATOM 306 O O . TYR A 1 37 ? 9.941 65.017 -13.244 1.00 21.39 ? 37 TYR A O 1 ATOM 307 C CB . TYR A 1 37 ? 11.486 62.684 -11.683 1.00 18.71 ? 37 TYR A CB 1 ATOM 308 C CG . TYR A 1 37 ? 12.299 62.812 -12.948 1.00 20.92 ? 37 TYR A CG 1 ATOM 309 C CD1 . TYR A 1 37 ? 12.356 61.767 -13.873 1.00 20.68 ? 37 TYR A CD1 1 ATOM 310 C CD2 . TYR A 1 37 ? 12.987 63.994 -13.243 1.00 20.25 ? 37 TYR A CD2 1 ATOM 311 C CE1 . TYR A 1 37 ? 13.081 61.894 -15.064 1.00 21.14 ? 37 TYR A CE1 1 ATOM 312 C CE2 . TYR A 1 37 ? 13.711 64.133 -14.430 1.00 19.72 ? 37 TYR A CE2 1 ATOM 313 C CZ . TYR A 1 37 ? 13.754 63.078 -15.335 1.00 21.14 ? 37 TYR A CZ 1 ATOM 314 O OH . TYR A 1 37 ? 14.478 63.204 -16.501 1.00 20.75 ? 37 TYR A OH 1 ATOM 315 N N . GLN A 1 38 ? 9.771 65.275 -11.006 1.00 22.10 ? 38 GLN A N 1 ATOM 316 C CA . GLN A 1 38 ? 9.691 66.724 -11.060 1.00 22.61 ? 38 GLN A CA 1 ATOM 317 C C . GLN A 1 38 ? 11.010 67.193 -11.666 1.00 23.20 ? 38 GLN A C 1 ATOM 318 O O . GLN A 1 38 ? 12.092 66.859 -11.170 1.00 24.13 ? 38 GLN A O 1 ATOM 319 C CB . GLN A 1 38 ? 9.500 67.281 -9.650 1.00 22.03 ? 38 GLN A CB 1 ATOM 320 C CG . GLN A 1 38 ? 8.151 66.927 -9.062 1.00 21.47 ? 38 GLN A CG 1 ATOM 321 C CD . GLN A 1 38 ? 7.017 67.655 -9.760 1.00 23.32 ? 38 GLN A CD 1 ATOM 322 O OE1 . GLN A 1 38 ? 6.721 68.807 -9.450 1.00 24.12 ? 38 GLN A OE1 1 ATOM 323 N NE2 . GLN A 1 38 ? 6.389 66.992 -10.720 1.00 22.93 ? 38 GLN A NE2 1 ATOM 324 N N . TYR A 1 39 ? 10.917 67.965 -12.740 1.00 22.41 ? 39 TYR A N 1 ATOM 325 C CA . TYR A 1 39 ? 12.103 68.430 -13.442 1.00 23.51 ? 39 TYR A CA 1 ATOM 326 C C . TYR A 1 39 ? 12.036 69.897 -13.866 1.00 24.60 ? 39 TYR A C 1 ATOM 327 O O . TYR A 1 39 ? 10.986 70.391 -14.281 1.00 25.26 ? 39 TYR A O 1 ATOM 328 C CB . TYR A 1 39 ? 12.305 67.540 -14.677 1.00 22.27 ? 39 TYR A CB 1 ATOM 329 C CG . TYR A 1 39 ? 13.478 67.887 -15.566 1.00 22.14 ? 39 TYR A CG 1 ATOM 330 C CD1 . TYR A 1 39 ? 13.276 68.348 -16.870 1.00 23.02 ? 39 TYR A CD1 1 ATOM 331 C CD2 . TYR A 1 39 ? 14.788 67.707 -15.127 1.00 22.12 ? 39 TYR A CD2 1 ATOM 332 C CE1 . TYR A 1 39 ? 14.355 68.614 -17.716 1.00 21.58 ? 39 TYR A CE1 1 ATOM 333 C CE2 . TYR A 1 39 ? 15.873 67.970 -15.963 1.00 22.38 ? 39 TYR A CE2 1 ATOM 334 C CZ . TYR A 1 39 ? 15.649 68.421 -17.254 1.00 23.81 ? 39 TYR A CZ 1 ATOM 335 O OH . TYR A 1 39 ? 16.720 68.659 -18.084 1.00 25.13 ? 39 TYR A OH 1 ATOM 336 N N . ASN A 1 40 ? 13.160 70.593 -13.736 1.00 24.68 ? 40 ASN A N 1 ATOM 337 C CA . ASN A 1 40 ? 13.242 71.978 -14.167 1.00 25.56 ? 40 ASN A CA 1 ATOM 338 C C . ASN A 1 40 ? 14.113 71.943 -15.415 1.00 26.32 ? 40 ASN A C 1 ATOM 339 O O . ASN A 1 40 ? 15.322 71.732 -15.340 1.00 26.87 ? 40 ASN A O 1 ATOM 340 C CB . ASN A 1 40 ? 13.907 72.867 -13.121 1.00 24.96 ? 40 ASN A CB 1 ATOM 341 C CG . ASN A 1 40 ? 13.878 74.338 -13.519 1.00 26.78 ? 40 ASN A CG 1 ATOM 342 O OD1 . ASN A 1 40 ? 13.791 74.667 -14.710 1.00 25.43 ? 40 ASN A OD1 1 ATOM 343 N ND2 . ASN A 1 40 ? 13.958 75.228 -12.530 1.00 24.02 ? 40 ASN A ND2 1 ATOM 344 N N . PRO A 1 41 ? 13.509 72.144 -16.586 1.00 27.24 ? 41 PRO A N 1 ATOM 345 C CA . PRO A 1 41 ? 14.309 72.110 -17.810 1.00 28.05 ? 41 PRO A CA 1 ATOM 346 C C . PRO A 1 41 ? 15.156 73.355 -18.051 1.00 29.72 ? 41 PRO A C 1 ATOM 347 O O . PRO A 1 41 ? 15.870 73.426 -19.050 1.00 32.18 ? 41 PRO A O 1 ATOM 348 C CB . PRO A 1 41 ? 13.255 71.908 -18.891 1.00 26.72 ? 41 PRO A CB 1 ATOM 349 C CG . PRO A 1 41 ? 12.093 72.708 -18.351 1.00 27.53 ? 41 PRO A CG 1 ATOM 350 C CD . PRO A 1 41 ? 12.077 72.341 -16.880 1.00 25.32 ? 41 PRO A CD 1 ATOM 351 N N . TYR A 1 42 ? 15.105 74.319 -17.134 1.00 29.94 ? 42 TYR A N 1 ATOM 352 C CA . TYR A 1 42 ? 15.858 75.557 -17.319 1.00 31.14 ? 42 TYR A CA 1 ATOM 353 C C . TYR A 1 42 ? 16.979 75.864 -16.332 1.00 31.54 ? 42 TYR A C 1 ATOM 354 O O . TYR A 1 42 ? 17.730 76.817 -16.540 1.00 33.49 ? 42 TYR A O 1 ATOM 355 C CB . TYR A 1 42 ? 14.891 76.743 -17.346 1.00 32.57 ? 42 TYR A CB 1 ATOM 356 C CG . TYR A 1 42 ? 13.772 76.565 -18.336 1.00 34.82 ? 42 TYR A CG 1 ATOM 357 C CD1 . TYR A 1 42 ? 12.446 76.521 -17.913 1.00 36.34 ? 42 TYR A CD1 1 ATOM 358 C CD2 . TYR A 1 42 ? 14.041 76.386 -19.693 1.00 36.16 ? 42 TYR A CD2 1 ATOM 359 C CE1 . TYR A 1 42 ? 11.409 76.297 -18.818 1.00 39.33 ? 42 TYR A CE1 1 ATOM 360 C CE2 . TYR A 1 42 ? 13.014 76.160 -20.608 1.00 37.69 ? 42 TYR A CE2 1 ATOM 361 C CZ . TYR A 1 42 ? 11.700 76.115 -20.163 1.00 39.35 ? 42 TYR A CZ 1 ATOM 362 O OH . TYR A 1 42 ? 10.679 75.881 -21.058 1.00 40.81 ? 42 TYR A OH 1 ATOM 363 N N . ALA A 1 43 ? 17.105 75.084 -15.264 1.00 30.31 ? 43 ALA A N 1 ATOM 364 C CA . ALA A 1 43 ? 18.159 75.349 -14.288 1.00 28.66 ? 43 ALA A CA 1 ATOM 365 C C . ALA A 1 43 ? 18.406 74.183 -13.337 1.00 28.86 ? 43 ALA A C 1 ATOM 366 O O . ALA A 1 43 ? 17.666 73.199 -13.331 1.00 27.94 ? 43 ALA A O 1 ATOM 367 C CB . ALA A 1 43 ? 17.817 76.607 -13.485 1.00 27.28 ? 43 ALA A CB 1 ATOM 368 N N . ALA A 1 44 ? 19.452 74.322 -12.528 1.00 28.40 ? 44 ALA A N 1 ATOM 369 C CA . ALA A 1 44 ? 19.836 73.312 -11.553 1.00 28.05 ? 44 ALA A CA 1 ATOM 370 C C . ALA A 1 44 ? 19.300 73.684 -10.173 1.00 28.42 ? 44 ALA A C 1 ATOM 371 O O . ALA A 1 44 ? 19.912 73.371 -9.151 1.00 28.40 ? 44 ALA A O 1 ATOM 372 C CB . ALA A 1 44 ? 21.356 73.183 -11.509 1.00 27.81 ? 44 ALA A CB 1 ATOM 373 N N . THR A 1 45 ? 18.160 74.366 -10.159 1.00 27.57 ? 45 THR A N 1 ATOM 374 C CA . THR A 1 45 ? 17.508 74.779 -8.921 1.00 27.91 ? 45 THR A CA 1 ATOM 375 C C . THR A 1 45 ? 16.010 74.653 -9.168 1.00 28.37 ? 45 THR A C 1 ATOM 376 O O . THR A 1 45 ? 15.590 74.362 -10.287 1.00 26.95 ? 45 THR A O 1 ATOM 377 C CB . THR A 1 45 ? 17.809 76.260 -8.575 1.00 30.04 ? 45 THR A CB 1 ATOM 378 O OG1 . THR A 1 45 ? 17.115 77.119 -9.492 1.00 27.71 ? 45 THR A OG1 1 ATOM 379 C CG2 . THR A 1 45 ? 19.303 76.544 -8.672 1.00 28.82 ? 45 THR A CG2 1 ATOM 380 N N . PHE A 1 46 ? 15.200 74.859 -8.136 1.00 28.62 ? 46 PHE A N 1 ATOM 381 C CA . PHE A 1 46 ? 13.759 74.789 -8.331 1.00 29.69 ? 46 PHE A CA 1 ATOM 382 C C . PHE A 1 46 ? 13.381 76.004 -9.188 1.00 31.52 ? 46 PHE A C 1 ATOM 383 O O . PHE A 1 46 ? 14.156 76.961 -9.281 1.00 31.38 ? 46 PHE A O 1 ATOM 384 C CB . PHE A 1 46 ? 13.026 74.846 -6.994 1.00 27.57 ? 46 PHE A CB 1 ATOM 385 C CG . PHE A 1 46 ? 11.588 74.428 -7.082 1.00 27.99 ? 46 PHE A CG 1 ATOM 386 C CD1 . PHE A 1 46 ? 11.253 73.101 -7.353 1.00 26.45 ? 46 PHE A CD1 1 ATOM 387 C CD2 . PHE A 1 46 ? 10.566 75.358 -6.918 1.00 25.20 ? 46 PHE A CD2 1 ATOM 388 C CE1 . PHE A 1 46 ? 9.918 72.707 -7.460 1.00 26.78 ? 46 PHE A CE1 1 ATOM 389 C CE2 . PHE A 1 46 ? 9.230 74.976 -7.022 1.00 27.34 ? 46 PHE A CE2 1 ATOM 390 C CZ . PHE A 1 46 ? 8.905 73.645 -7.294 1.00 26.88 ? 46 PHE A CZ 1 ATOM 391 N N . GLY A 1 47 ? 12.209 75.974 -9.817 1.00 32.40 ? 47 GLY A N 1 ATOM 392 C CA . GLY A 1 47 ? 11.814 77.096 -10.653 1.00 32.09 ? 47 GLY A CA 1 ATOM 393 C C . GLY A 1 47 ? 10.325 77.254 -10.897 1.00 33.12 ? 47 GLY A C 1 ATOM 394 O O . GLY A 1 47 ? 9.517 76.414 -10.494 1.00 33.08 ? 47 GLY A O 1 ATOM 395 N N . ASP A 1 48 ? 9.971 78.345 -11.570 1.00 33.56 ? 48 ASP A N 1 ATOM 396 C CA . ASP A 1 48 ? 8.584 78.661 -11.891 1.00 34.50 ? 48 ASP A CA 1 ATOM 397 C C . ASP A 1 48 ? 7.948 77.622 -12.797 1.00 34.04 ? 48 ASP A C 1 ATOM 398 O O . ASP A 1 48 ? 6.732 77.436 -12.774 1.00 35.06 ? 48 ASP A O 1 ATOM 399 C CB . ASP A 1 48 ? 8.504 80.027 -12.572 1.00 36.59 ? 48 ASP A CB 1 ATOM 400 C CG . ASP A 1 48 ? 8.848 81.163 -11.637 1.00 39.67 ? 48 ASP A CG 1 ATOM 401 O OD1 . ASP A 1 48 ? 9.164 82.262 -12.141 1.00 41.36 ? 48 ASP A OD1 1 ATOM 402 O OD2 . ASP A 1 48 ? 8.791 80.959 -10.402 1.00 39.20 ? 48 ASP A OD2 1 ATOM 403 N N . VAL A 1 49 ? 8.767 76.959 -13.605 1.00 31.65 ? 49 VAL A N 1 ATOM 404 C CA . VAL A 1 49 ? 8.262 75.941 -14.509 1.00 31.64 ? 49 VAL A CA 1 ATOM 405 C C . VAL A 1 49 ? 8.849 74.564 -14.214 1.00 30.90 ? 49 VAL A C 1 ATOM 406 O O . VAL A 1 49 ? 10.009 74.288 -14.523 1.00 30.63 ? 49 VAL A O 1 ATOM 407 C CB . VAL A 1 49 ? 8.553 76.303 -15.986 1.00 33.46 ? 49 VAL A CB 1 ATOM 408 C CG1 . VAL A 1 49 ? 8.091 75.174 -16.903 1.00 30.10 ? 49 VAL A CG1 1 ATOM 409 C CG2 . VAL A 1 49 ? 7.835 77.598 -16.353 1.00 32.02 ? 49 VAL A CG2 1 ATOM 410 N N . ILE A 1 50 ? 8.034 73.711 -13.601 1.00 29.41 ? 50 ILE A N 1 ATOM 411 C CA . ILE A 1 50 ? 8.432 72.348 -13.271 1.00 27.89 ? 50 ILE A CA 1 ATOM 412 C C . ILE A 1 50 ? 7.569 71.394 -14.092 1.00 27.95 ? 50 ILE A C 1 ATOM 413 O O . ILE A 1 50 ? 6.346 71.543 -14.152 1.00 28.16 ? 50 ILE A O 1 ATOM 414 C CB . ILE A 1 50 ? 8.227 72.042 -11.770 1.00 27.20 ? 50 ILE A CB 1 ATOM 415 C CG1 . ILE A 1 50 ? 9.228 72.843 -10.931 1.00 25.81 ? 50 ILE A CG1 1 ATOM 416 C CG2 . ILE A 1 50 ? 8.382 70.543 -11.518 1.00 26.52 ? 50 ILE A CG2 1 ATOM 417 C CD1 . ILE A 1 50 ? 10.690 72.502 -11.207 1.00 22.96 ? 50 ILE A CD1 1 ATOM 418 N N . ILE A 1 51 ? 8.208 70.418 -14.726 1.00 26.57 ? 51 ILE A N 1 ATOM 419 C CA . ILE A 1 51 ? 7.486 69.457 -15.547 1.00 24.27 ? 51 ILE A CA 1 ATOM 420 C C . ILE A 1 51 ? 7.886 68.026 -15.192 1.00 25.31 ? 51 ILE A C 1 ATOM 421 O O . ILE A 1 51 ? 8.823 67.806 -14.423 1.00 25.27 ? 51 ILE A O 1 ATOM 422 C CB . ILE A 1 51 ? 7.764 69.703 -17.040 1.00 22.63 ? 51 ILE A CB 1 ATOM 423 C CG1 . ILE A 1 51 ? 9.246 69.482 -17.341 1.00 20.51 ? 51 ILE A CG1 1 ATOM 424 C CG2 . ILE A 1 51 ? 7.382 71.131 -17.406 1.00 22.90 ? 51 ILE A CG2 1 ATOM 425 C CD1 . ILE A 1 51 ? 9.624 69.736 -18.794 1.00 19.90 ? 51 ILE A CD1 1 ATOM 426 N N . TRP A 1 52 ? 7.167 67.060 -15.758 1.00 23.69 ? 52 TRP A N 1 ATOM 427 C CA . TRP A 1 52 ? 7.438 65.651 -15.516 1.00 21.58 ? 52 TRP A CA 1 ATOM 428 C C . TRP A 1 52 ? 8.470 65.077 -16.478 1.00 22.21 ? 52 TRP A C 1 ATOM 429 O O . TRP A 1 52 ? 8.202 64.934 -17.672 1.00 23.31 ? 52 TRP A O 1 ATOM 430 C CB . TRP A 1 52 ? 6.151 64.829 -15.653 1.00 21.40 ? 52 TRP A CB 1 ATOM 431 C CG . TRP A 1 52 ? 5.227 64.896 -14.472 1.00 20.22 ? 52 TRP A CG 1 ATOM 432 C CD1 . TRP A 1 52 ? 4.937 65.994 -13.714 1.00 18.37 ? 52 TRP A CD1 1 ATOM 433 C CD2 . TRP A 1 52 ? 4.456 63.815 -13.926 1.00 17.68 ? 52 TRP A CD2 1 ATOM 434 N NE1 . TRP A 1 52 ? 4.037 65.664 -12.728 1.00 18.44 ? 52 TRP A NE1 1 ATOM 435 C CE2 . TRP A 1 52 ? 3.725 64.334 -12.835 1.00 16.61 ? 52 TRP A CE2 1 ATOM 436 C CE3 . TRP A 1 52 ? 4.313 62.458 -14.255 1.00 20.18 ? 52 TRP A CE3 1 ATOM 437 C CZ2 . TRP A 1 52 ? 2.863 63.543 -12.064 1.00 16.27 ? 52 TRP A CZ2 1 ATOM 438 C CZ3 . TRP A 1 52 ? 3.450 61.668 -13.487 1.00 18.80 ? 52 TRP A CZ3 1 ATOM 439 C CH2 . TRP A 1 52 ? 2.739 62.218 -12.404 1.00 18.26 ? 52 TRP A CH2 1 ATOM 440 N N . GLY A 1 53 ? 9.650 64.755 -15.957 1.00 22.74 ? 53 GLY A N 1 ATOM 441 C CA . GLY A 1 53 ? 10.670 64.134 -16.784 1.00 21.48 ? 53 GLY A CA 1 ATOM 442 C C . GLY A 1 53 ? 10.179 62.710 -16.985 1.00 21.83 ? 53 GLY A C 1 ATOM 443 O O . GLY A 1 53 ? 9.324 62.248 -16.225 1.00 20.37 ? 53 GLY A O 1 ATOM 444 N N . HIS A 1 54 ? 10.710 62.002 -17.979 1.00 21.89 ? 54 HIS A N 1 ATOM 445 C CA . HIS A 1 54 ? 10.255 60.643 -18.261 1.00 20.41 ? 54 HIS A CA 1 ATOM 446 C C . HIS A 1 54 ? 11.402 59.748 -18.724 1.00 21.31 ? 54 HIS A C 1 ATOM 447 O O . HIS A 1 54 ? 12.224 60.152 -19.547 1.00 21.83 ? 54 HIS A O 1 ATOM 448 C CB . HIS A 1 54 ? 9.148 60.718 -19.327 1.00 21.11 ? 54 HIS A CB 1 ATOM 449 C CG . HIS A 1 54 ? 8.502 59.406 -19.662 1.00 21.55 ? 54 HIS A CG 1 ATOM 450 N ND1 . HIS A 1 54 ? 8.441 58.347 -18.780 1.00 24.37 ? 54 HIS A ND1 1 ATOM 451 C CD2 . HIS A 1 54 ? 7.822 59.011 -20.765 1.00 21.07 ? 54 HIS A CD2 1 ATOM 452 C CE1 . HIS A 1 54 ? 7.752 57.360 -19.325 1.00 21.94 ? 54 HIS A CE1 1 ATOM 453 N NE2 . HIS A 1 54 ? 7.363 57.738 -20.529 1.00 21.11 ? 54 HIS A NE2 1 ATOM 454 N N . ALA A 1 55 ? 11.458 58.538 -18.170 1.00 20.71 ? 55 ALA A N 1 ATOM 455 C CA . ALA A 1 55 ? 12.478 57.554 -18.522 1.00 20.28 ? 55 ALA A CA 1 ATOM 456 C C . ALA A 1 55 ? 11.854 56.168 -18.419 1.00 21.37 ? 55 ALA A C 1 ATOM 457 O O . ALA A 1 55 ? 10.893 55.967 -17.671 1.00 21.00 ? 55 ALA A O 1 ATOM 458 C CB . ALA A 1 55 ? 13.666 57.656 -17.582 1.00 19.07 ? 55 ALA A CB 1 ATOM 459 N N . VAL A 1 56 ? 12.387 55.218 -19.182 1.00 20.05 ? 56 VAL A N 1 ATOM 460 C CA . VAL A 1 56 ? 11.868 53.862 -19.153 1.00 19.91 ? 56 VAL A CA 1 ATOM 461 C C . VAL A 1 56 ? 12.991 52.855 -18.954 1.00 20.57 ? 56 VAL A C 1 ATOM 462 O O . VAL A 1 56 ? 14.158 53.144 -19.238 1.00 19.95 ? 56 VAL A O 1 ATOM 463 C CB . VAL A 1 56 ? 11.094 53.520 -20.453 1.00 20.14 ? 56 VAL A CB 1 ATOM 464 C CG1 . VAL A 1 56 ? 9.835 54.360 -20.537 1.00 19.15 ? 56 VAL A CG1 1 ATOM 465 C CG2 . VAL A 1 56 ? 11.974 53.753 -21.674 1.00 18.64 ? 56 VAL A CG2 1 ATOM 466 N N . SER A 1 57 ? 12.629 51.673 -18.466 1.00 20.00 ? 57 SER A N 1 ATOM 467 C CA . SER A 1 57 ? 13.599 50.616 -18.211 1.00 21.84 ? 57 SER A CA 1 ATOM 468 C C . SER A 1 57 ? 12.953 49.234 -18.180 1.00 22.74 ? 57 SER A C 1 ATOM 469 O O . SER A 1 57 ? 11.761 49.099 -17.895 1.00 23.21 ? 57 SER A O 1 ATOM 470 C CB . SER A 1 57 ? 14.297 50.864 -16.873 1.00 20.66 ? 57 SER A CB 1 ATOM 471 O OG . SER A 1 57 ? 15.074 49.742 -16.503 1.00 21.37 ? 57 SER A OG 1 ATOM 472 N N . TYR A 1 58 ? 13.750 48.212 -18.468 1.00 22.25 ? 58 TYR A N 1 ATOM 473 C CA . TYR A 1 58 ? 13.271 46.836 -18.447 1.00 24.88 ? 58 TYR A CA 1 ATOM 474 C C . TYR A 1 58 ? 13.733 46.140 -17.167 1.00 24.81 ? 58 TYR A C 1 ATOM 475 O O . TYR A 1 58 ? 13.273 45.040 -16.860 1.00 26.07 ? 58 TYR A O 1 ATOM 476 C CB . TYR A 1 58 ? 13.812 46.061 -19.651 1.00 24.71 ? 58 TYR A CB 1 ATOM 477 C CG . TYR A 1 58 ? 13.403 46.628 -20.987 1.00 28.27 ? 58 TYR A CG 1 ATOM 478 C CD1 . TYR A 1 58 ? 12.099 46.485 -21.464 1.00 29.04 ? 58 TYR A CD1 1 ATOM 479 C CD2 . TYR A 1 58 ? 14.319 47.321 -21.773 1.00 30.26 ? 58 TYR A CD2 1 ATOM 480 C CE1 . TYR A 1 58 ? 11.719 47.020 -22.699 1.00 30.43 ? 58 TYR A CE1 1 ATOM 481 C CE2 . TYR A 1 58 ? 13.952 47.861 -23.005 1.00 32.16 ? 58 TYR A CE2 1 ATOM 482 C CZ . TYR A 1 58 ? 12.655 47.708 -23.461 1.00 32.27 ? 58 TYR A CZ 1 ATOM 483 O OH . TYR A 1 58 ? 12.307 48.243 -24.683 1.00 36.98 ? 58 TYR A OH 1 ATOM 484 N N . ASP A 1 59 ? 14.633 46.782 -16.423 1.00 23.88 ? 59 ASP A N 1 ATOM 485 C CA . ASP A 1 59 ? 15.172 46.188 -15.197 1.00 24.48 ? 59 ASP A CA 1 ATOM 486 C C . ASP A 1 59 ? 15.311 47.122 -13.978 1.00 23.97 ? 59 ASP A C 1 ATOM 487 O O . ASP A 1 59 ? 15.791 46.695 -12.929 1.00 24.08 ? 59 ASP A O 1 ATOM 488 C CB . ASP A 1 59 ? 16.540 45.572 -15.496 1.00 22.28 ? 59 ASP A CB 1 ATOM 489 C CG . ASP A 1 59 ? 17.490 46.558 -16.162 1.00 25.37 ? 59 ASP A CG 1 ATOM 490 O OD1 . ASP A 1 59 ? 17.396 47.774 -15.883 1.00 26.20 ? 59 ASP A OD1 1 ATOM 491 O OD2 . ASP A 1 59 ? 18.343 46.120 -16.959 1.00 26.97 ? 59 ASP A OD2 1 ATOM 492 N N . LEU A 1 60 ? 14.897 48.379 -14.118 1.00 23.29 ? 60 LEU A N 1 ATOM 493 C CA . LEU A 1 60 ? 14.987 49.367 -13.038 1.00 22.27 ? 60 LEU A CA 1 ATOM 494 C C . LEU A 1 60 ? 16.424 49.821 -12.762 1.00 22.59 ? 60 LEU A C 1 ATOM 495 O O . LEU A 1 60 ? 16.664 50.608 -11.848 1.00 23.28 ? 60 LEU A O 1 ATOM 496 C CB . LEU A 1 60 ? 14.361 48.825 -11.743 1.00 21.49 ? 60 LEU A CB 1 ATOM 497 C CG . LEU A 1 60 ? 12.828 48.724 -11.690 1.00 21.77 ? 60 LEU A CG 1 ATOM 498 C CD1 . LEU A 1 60 ? 12.402 48.009 -10.412 1.00 19.31 ? 60 LEU A CD1 1 ATOM 499 C CD2 . LEU A 1 60 ? 12.212 50.120 -11.748 1.00 19.54 ? 60 LEU A CD2 1 ATOM 500 N N . VAL A 1 61 ? 17.376 49.331 -13.554 1.00 21.30 ? 61 VAL A N 1 ATOM 501 C CA . VAL A 1 61 ? 18.779 49.706 -13.380 1.00 20.65 ? 61 VAL A CA 1 ATOM 502 C C . VAL A 1 61 ? 19.281 50.548 -14.553 1.00 21.39 ? 61 VAL A C 1 ATOM 503 O O . VAL A 1 61 ? 19.847 51.625 -14.365 1.00 20.98 ? 61 VAL A O 1 ATOM 504 C CB . VAL A 1 61 ? 19.689 48.462 -13.265 1.00 20.03 ? 61 VAL A CB 1 ATOM 505 C CG1 . VAL A 1 61 ? 21.137 48.895 -13.095 1.00 20.78 ? 61 VAL A CG1 1 ATOM 506 C CG2 . VAL A 1 61 ? 19.253 47.601 -12.096 1.00 20.08 ? 61 VAL A CG2 1 ATOM 507 N N . ASN A 1 62 ? 19.083 50.034 -15.762 1.00 20.72 ? 62 ASN A N 1 ATOM 508 C CA . ASN A 1 62 ? 19.504 50.719 -16.977 1.00 20.94 ? 62 ASN A CA 1 ATOM 509 C C . ASN A 1 62 ? 18.318 51.489 -17.539 1.00 21.09 ? 62 ASN A C 1 ATOM 510 O O . ASN A 1 62 ? 17.224 50.940 -17.680 1.00 21.56 ? 62 ASN A O 1 ATOM 511 C CB . ASN A 1 62 ? 20.021 49.688 -17.976 1.00 19.81 ? 62 ASN A CB 1 ATOM 512 C CG . ASN A 1 62 ? 21.144 48.852 -17.395 1.00 21.96 ? 62 ASN A CG 1 ATOM 513 O OD1 . ASN A 1 62 ? 22.233 49.366 -17.122 1.00 19.68 ? 62 ASN A OD1 1 ATOM 514 N ND2 . ASN A 1 62 ? 20.880 47.564 -17.176 1.00 19.51 ? 62 ASN A ND2 1 ATOM 515 N N . TRP A 1 63 ? 18.535 52.759 -17.862 1.00 20.58 ? 63 TRP A N 1 ATOM 516 C CA . TRP A 1 63 ? 17.453 53.598 -18.351 1.00 20.85 ? 63 TRP A CA 1 ATOM 517 C C . TRP A 1 63 ? 17.638 54.277 -19.688 1.00 21.75 ? 63 TRP A C 1 ATOM 518 O O . TRP A 1 63 ? 18.751 54.426 -20.196 1.00 22.72 ? 63 TRP A O 1 ATOM 519 C CB . TRP A 1 63 ? 17.135 54.685 -17.321 1.00 20.28 ? 63 TRP A CB 1 ATOM 520 C CG . TRP A 1 63 ? 16.720 54.147 -15.995 1.00 20.67 ? 63 TRP A CG 1 ATOM 521 C CD1 . TRP A 1 63 ? 17.536 53.725 -14.985 1.00 19.02 ? 63 TRP A CD1 1 ATOM 522 C CD2 . TRP A 1 63 ? 15.378 53.917 -15.553 1.00 19.83 ? 63 TRP A CD2 1 ATOM 523 N NE1 . TRP A 1 63 ? 16.783 53.244 -13.938 1.00 20.26 ? 63 TRP A NE1 1 ATOM 524 C CE2 . TRP A 1 63 ? 15.456 53.349 -14.261 1.00 20.04 ? 63 TRP A CE2 1 ATOM 525 C CE3 . TRP A 1 63 ? 14.116 54.133 -16.125 1.00 19.19 ? 63 TRP A CE3 1 ATOM 526 C CZ2 . TRP A 1 63 ? 14.318 52.993 -13.528 1.00 19.92 ? 63 TRP A CZ2 1 ATOM 527 C CZ3 . TRP A 1 63 ? 12.982 53.780 -15.398 1.00 20.89 ? 63 TRP A CZ3 1 ATOM 528 C CH2 . TRP A 1 63 ? 13.093 53.215 -14.110 1.00 20.77 ? 63 TRP A CH2 1 ATOM 529 N N . ILE A 1 64 ? 16.507 54.701 -20.239 1.00 22.26 ? 64 ILE A N 1 ATOM 530 C CA . ILE A 1 64 ? 16.462 55.430 -21.491 1.00 21.75 ? 64 ILE A CA 1 ATOM 531 C C . ILE A 1 64 ? 15.689 56.709 -21.193 1.00 22.69 ? 64 ILE A C 1 ATOM 532 O O . ILE A 1 64 ? 14.515 56.656 -20.804 1.00 23.11 ? 64 ILE A O 1 ATOM 533 C CB . ILE A 1 64 ? 15.725 54.641 -22.585 1.00 21.78 ? 64 ILE A CB 1 ATOM 534 C CG1 . ILE A 1 64 ? 16.504 53.364 -22.921 1.00 20.46 ? 64 ILE A CG1 1 ATOM 535 C CG2 . ILE A 1 64 ? 15.556 55.509 -23.824 1.00 17.42 ? 64 ILE A CG2 1 ATOM 536 C CD1 . ILE A 1 64 ? 15.807 52.475 -23.942 1.00 18.88 ? 64 ILE A CD1 1 ATOM 537 N N . HIS A 1 65 ? 16.358 57.850 -21.343 1.00 22.23 ? 65 HIS A N 1 ATOM 538 C CA . HIS A 1 65 ? 15.735 59.147 -21.097 1.00 21.46 ? 65 HIS A CA 1 ATOM 539 C C . HIS A 1 65 ? 14.889 59.542 -22.303 1.00 23.23 ? 65 HIS A C 1 ATOM 540 O O . HIS A 1 65 ? 15.367 59.510 -23.439 1.00 23.26 ? 65 HIS A O 1 ATOM 541 C CB . HIS A 1 65 ? 16.803 60.215 -20.865 1.00 21.75 ? 65 HIS A CB 1 ATOM 542 C CG . HIS A 1 65 ? 17.635 59.988 -19.642 1.00 22.33 ? 65 HIS A CG 1 ATOM 543 N ND1 . HIS A 1 65 ? 17.111 60.026 -18.369 1.00 22.16 ? 65 HIS A ND1 1 ATOM 544 C CD2 . HIS A 1 65 ? 18.956 59.720 -19.500 1.00 21.20 ? 65 HIS A CD2 1 ATOM 545 C CE1 . HIS A 1 65 ? 18.074 59.790 -17.493 1.00 23.47 ? 65 HIS A CE1 1 ATOM 546 N NE2 . HIS A 1 65 ? 19.202 59.600 -18.153 1.00 22.73 ? 65 HIS A NE2 1 ATOM 547 N N . LEU A 1 66 ? 13.637 59.911 -22.051 1.00 23.34 ? 66 LEU A N 1 ATOM 548 C CA . LEU A 1 66 ? 12.719 60.322 -23.112 1.00 23.21 ? 66 LEU A CA 1 ATOM 549 C C . LEU A 1 66 ? 12.400 61.806 -22.934 1.00 25.12 ? 66 LEU A C 1 ATOM 550 O O . LEU A 1 66 ? 12.970 62.467 -22.065 1.00 26.95 ? 66 LEU A O 1 ATOM 551 C CB . LEU A 1 66 ? 11.426 59.506 -23.030 1.00 20.69 ? 66 LEU A CB 1 ATOM 552 C CG . LEU A 1 66 ? 11.563 57.980 -23.039 1.00 21.41 ? 66 LEU A CG 1 ATOM 553 C CD1 . LEU A 1 66 ? 10.222 57.334 -22.702 1.00 18.83 ? 66 LEU A CD1 1 ATOM 554 C CD2 . LEU A 1 66 ? 12.057 57.514 -24.398 1.00 21.07 ? 66 LEU A CD2 1 ATOM 555 N N . ASP A 1 67 ? 11.504 62.334 -23.762 1.00 25.84 ? 67 ASP A N 1 ATOM 556 C CA . ASP A 1 67 ? 11.111 63.737 -23.648 1.00 26.57 ? 67 ASP A CA 1 ATOM 557 C C . ASP A 1 67 ? 10.105 63.849 -22.509 1.00 24.79 ? 67 ASP A C 1 ATOM 558 O O . ASP A 1 67 ? 9.436 62.876 -22.174 1.00 24.37 ? 67 ASP A O 1 ATOM 559 C CB . ASP A 1 67 ? 10.454 64.234 -24.943 1.00 28.68 ? 67 ASP A CB 1 ATOM 560 C CG . ASP A 1 67 ? 11.437 64.350 -26.093 1.00 32.75 ? 67 ASP A CG 1 ATOM 561 O OD1 . ASP A 1 67 ? 12.491 65.004 -25.921 1.00 33.08 ? 67 ASP A OD1 1 ATOM 562 O OD2 . ASP A 1 67 ? 11.147 63.793 -27.174 1.00 35.72 ? 67 ASP A OD2 1 ATOM 563 N N . PRO A 1 68 ? 9.995 65.033 -21.891 1.00 24.38 ? 68 PRO A N 1 ATOM 564 C CA . PRO A 1 68 ? 9.040 65.201 -20.793 1.00 24.31 ? 68 PRO A CA 1 ATOM 565 C C . PRO A 1 68 ? 7.667 64.699 -21.217 1.00 24.68 ? 68 PRO A C 1 ATOM 566 O O . PRO A 1 68 ? 7.254 64.896 -22.358 1.00 26.79 ? 68 PRO A O 1 ATOM 567 C CB . PRO A 1 68 ? 9.081 66.700 -20.540 1.00 24.16 ? 68 PRO A CB 1 ATOM 568 C CG . PRO A 1 68 ? 10.541 67.008 -20.773 1.00 23.55 ? 68 PRO A CG 1 ATOM 569 C CD . PRO A 1 68 ? 10.820 66.243 -22.061 1.00 24.00 ? 68 PRO A CD 1 ATOM 570 N N . ALA A 1 69 ? 6.968 64.040 -20.298 1.00 24.86 ? 69 ALA A N 1 ATOM 571 C CA . ALA A 1 69 ? 5.658 63.473 -20.593 1.00 24.34 ? 69 ALA A CA 1 ATOM 572 C C . ALA A 1 69 ? 4.489 64.389 -20.245 1.00 24.44 ? 69 ALA A C 1 ATOM 573 O O . ALA A 1 69 ? 3.518 64.487 -20.994 1.00 24.21 ? 69 ALA A O 1 ATOM 574 C CB . ALA A 1 69 ? 5.504 62.136 -19.863 1.00 21.95 ? 69 ALA A CB 1 ATOM 575 N N . ILE A 1 70 ? 4.583 65.058 -19.105 1.00 24.84 ? 70 ILE A N 1 ATOM 576 C CA . ILE A 1 70 ? 3.518 65.939 -18.667 1.00 25.30 ? 70 ILE A CA 1 ATOM 577 C C . ILE A 1 70 ? 4.057 67.342 -18.422 1.00 27.29 ? 70 ILE A C 1 ATOM 578 O O . ILE A 1 70 ? 4.967 67.541 -17.613 1.00 28.52 ? 70 ILE A O 1 ATOM 579 C CB . ILE A 1 70 ? 2.847 65.366 -17.394 1.00 24.39 ? 70 ILE A CB 1 ATOM 580 C CG1 . ILE A 1 70 ? 2.152 64.044 -17.752 1.00 23.33 ? 70 ILE A CG1 1 ATOM 581 C CG2 . ILE A 1 70 ? 1.840 66.357 -16.822 1.00 22.31 ? 70 ILE A CG2 1 ATOM 582 C CD1 . ILE A 1 70 ? 1.487 63.349 -16.588 1.00 23.81 ? 70 ILE A CD1 1 ATOM 583 N N . TYR A 1 71 ? 3.498 68.306 -19.147 1.00 26.04 ? 71 TYR A N 1 ATOM 584 C CA . TYR A 1 71 ? 3.910 69.698 -19.042 1.00 26.71 ? 71 TYR A CA 1 ATOM 585 C C . TYR A 1 71 ? 2.705 70.596 -19.297 1.00 27.41 ? 71 TYR A C 1 ATOM 586 O O . TYR A 1 71 ? 1.718 70.168 -19.902 1.00 28.88 ? 71 TYR A O 1 ATOM 587 C CB . TYR A 1 71 ? 5.023 69.979 -20.052 1.00 25.78 ? 71 TYR A CB 1 ATOM 588 C CG . TYR A 1 71 ? 4.736 69.419 -21.420 1.00 25.89 ? 71 TYR A CG 1 ATOM 589 C CD1 . TYR A 1 71 ? 3.920 70.107 -22.322 1.00 25.67 ? 71 TYR A CD1 1 ATOM 590 C CD2 . TYR A 1 71 ? 5.230 68.164 -21.796 1.00 25.89 ? 71 TYR A CD2 1 ATOM 591 C CE1 . TYR A 1 71 ? 3.600 69.556 -23.567 1.00 24.98 ? 71 TYR A CE1 1 ATOM 592 C CE2 . TYR A 1 71 ? 4.915 67.603 -23.031 1.00 24.49 ? 71 TYR A CE2 1 ATOM 593 C CZ . TYR A 1 71 ? 4.099 68.304 -23.911 1.00 26.52 ? 71 TYR A CZ 1 ATOM 594 O OH . TYR A 1 71 ? 3.767 67.741 -25.121 1.00 28.40 ? 71 TYR A OH 1 ATOM 595 N N . PRO A 1 72 ? 2.770 71.855 -18.837 1.00 26.20 ? 72 PRO A N 1 ATOM 596 C CA . PRO A 1 72 ? 1.682 72.827 -19.002 1.00 25.66 ? 72 PRO A CA 1 ATOM 597 C C . PRO A 1 72 ? 1.102 72.925 -20.413 1.00 25.95 ? 72 PRO A C 1 ATOM 598 O O . PRO A 1 72 ? 1.824 73.231 -21.360 1.00 25.88 ? 72 PRO A O 1 ATOM 599 C CB . PRO A 1 72 ? 2.326 74.141 -18.566 1.00 25.00 ? 72 PRO A CB 1 ATOM 600 C CG . PRO A 1 72 ? 3.334 73.698 -17.535 1.00 25.98 ? 72 PRO A CG 1 ATOM 601 C CD . PRO A 1 72 ? 3.938 72.478 -18.189 1.00 26.14 ? 72 PRO A CD 1 ATOM 602 N N . THR A 1 73 ? -0.197 72.656 -20.540 1.00 25.32 ? 73 THR A N 1 ATOM 603 C CA . THR A 1 73 ? -0.897 72.758 -21.823 1.00 26.60 ? 73 THR A CA 1 ATOM 604 C C . THR A 1 73 ? -2.331 73.259 -21.638 1.00 27.24 ? 73 THR A C 1 ATOM 605 O O . THR A 1 73 ? -2.991 73.619 -22.608 1.00 28.29 ? 73 THR A O 1 ATOM 606 C CB . THR A 1 73 ? -0.969 71.411 -22.585 1.00 25.90 ? 73 THR A CB 1 ATOM 607 O OG1 . THR A 1 73 ? -1.588 70.422 -21.754 1.00 25.68 ? 73 THR A OG1 1 ATOM 608 C CG2 . THR A 1 73 ? 0.416 70.955 -23.015 1.00 23.54 ? 73 THR A CG2 1 ATOM 609 N N . GLN A 1 74 ? -2.810 73.267 -20.396 1.00 26.86 ? 74 GLN A N 1 ATOM 610 C CA . GLN A 1 74 ? -4.164 73.729 -20.094 1.00 27.52 ? 74 GLN A CA 1 ATOM 611 C C . GLN A 1 74 ? -4.129 74.813 -19.031 1.00 29.15 ? 74 GLN A C 1 ATOM 612 O O . GLN A 1 74 ? -3.086 75.103 -18.446 1.00 30.35 ? 74 GLN A O 1 ATOM 613 C CB . GLN A 1 74 ? -5.034 72.600 -19.539 1.00 27.66 ? 74 GLN A CB 1 ATOM 614 C CG . GLN A 1 74 ? -5.286 71.421 -20.438 1.00 27.44 ? 74 GLN A CG 1 ATOM 615 C CD . GLN A 1 74 ? -6.098 70.360 -19.718 1.00 28.79 ? 74 GLN A CD 1 ATOM 616 O OE1 . GLN A 1 74 ? -5.708 69.891 -18.645 1.00 29.42 ? 74 GLN A OE1 1 ATOM 617 N NE2 . GLN A 1 74 ? -7.234 69.983 -20.295 1.00 26.65 ? 74 GLN A NE2 1 ATOM 618 N N . GLU A 1 75 ? -5.291 75.396 -18.770 1.00 29.03 ? 75 GLU A N 1 ATOM 619 C CA . GLU A 1 75 ? -5.405 76.421 -17.751 1.00 29.66 ? 75 GLU A CA 1 ATOM 620 C C . GLU A 1 75 ? -5.204 75.713 -16.416 1.00 28.82 ? 75 GLU A C 1 ATOM 621 O O . GLU A 1 75 ? -4.642 76.281 -15.485 1.00 29.04 ? 75 GLU A O 1 ATOM 622 C CB . GLU A 1 75 ? -6.796 77.065 -17.814 1.00 29.46 ? 75 GLU A CB 1 ATOM 623 C CG . GLU A 1 75 ? -7.075 78.159 -16.781 1.00 30.26 ? 75 GLU A CG 1 ATOM 624 C CD . GLU A 1 75 ? -7.298 77.618 -15.373 1.00 32.34 ? 75 GLU A CD 1 ATOM 625 O OE1 . GLU A 1 75 ? -7.916 76.537 -15.237 1.00 31.67 ? 75 GLU A OE1 1 ATOM 626 O OE2 . GLU A 1 75 ? -6.871 78.283 -14.404 1.00 31.00 ? 75 GLU A OE2 1 ATOM 627 N N . ALA A 1 76 ? -5.649 74.458 -16.353 1.00 28.68 ? 76 ALA A N 1 ATOM 628 C CA . ALA A 1 76 ? -5.554 73.639 -15.145 1.00 27.94 ? 76 ALA A CA 1 ATOM 629 C C . ALA A 1 76 ? -4.129 73.284 -14.702 1.00 27.93 ? 76 ALA A C 1 ATOM 630 O O . ALA A 1 76 ? -3.936 72.777 -13.596 1.00 27.65 ? 76 ALA A O 1 ATOM 631 C CB . ALA A 1 76 ? -6.380 72.367 -15.317 1.00 27.60 ? 76 ALA A CB 1 ATOM 632 N N . ASP A 1 77 ? -3.135 73.534 -15.551 1.00 26.89 ? 77 ASP A N 1 ATOM 633 C CA . ASP A 1 77 ? -1.750 73.260 -15.170 1.00 27.55 ? 77 ASP A CA 1 ATOM 634 C C . ASP A 1 77 ? -0.791 74.205 -15.877 1.00 27.46 ? 77 ASP A C 1 ATOM 635 O O . ASP A 1 77 ? 0.390 73.908 -16.033 1.00 26.57 ? 77 ASP A O 1 ATOM 636 C CB . ASP A 1 77 ? -1.371 71.797 -15.465 1.00 28.38 ? 77 ASP A CB 1 ATOM 637 C CG . ASP A 1 77 ? -1.304 71.478 -16.952 1.00 29.09 ? 77 ASP A CG 1 ATOM 638 O OD1 . ASP A 1 77 ? -1.477 72.385 -17.793 1.00 30.34 ? 77 ASP A OD1 1 ATOM 639 O OD2 . ASP A 1 77 ? -1.067 70.296 -17.280 1.00 28.75 ? 77 ASP A OD2 1 ATOM 640 N N . SER A 1 78 ? -1.312 75.362 -16.272 1.00 27.95 ? 78 SER A N 1 ATOM 641 C CA . SER A 1 78 ? -0.546 76.374 -16.994 1.00 29.04 ? 78 SER A CA 1 ATOM 642 C C . SER A 1 78 ? 0.739 76.869 -16.345 1.00 29.04 ? 78 SER A C 1 ATOM 643 O O . SER A 1 78 ? 1.680 77.240 -17.048 1.00 29.41 ? 78 SER A O 1 ATOM 644 C CB . SER A 1 78 ? -1.444 77.578 -17.304 1.00 29.39 ? 78 SER A CB 1 ATOM 645 O OG . SER A 1 78 ? -2.074 78.069 -16.133 1.00 30.69 ? 78 SER A OG 1 ATOM 646 N N . LYS A 1 79 ? 0.789 76.875 -15.016 1.00 29.72 ? 79 LYS A N 1 ATOM 647 C CA . LYS A 1 79 ? 1.971 77.362 -14.316 1.00 29.76 ? 79 LYS A CA 1 ATOM 648 C C . LYS A 1 79 ? 3.008 76.314 -13.935 1.00 29.98 ? 79 LYS A C 1 ATOM 649 O O . LYS A 1 79 ? 4.156 76.659 -13.654 1.00 29.95 ? 79 LYS A O 1 ATOM 650 C CB . LYS A 1 79 ? 1.553 78.137 -13.067 1.00 32.88 ? 79 LYS A CB 1 ATOM 651 C CG . LYS A 1 79 ? 0.920 79.481 -13.377 1.00 35.66 ? 79 LYS A CG 1 ATOM 652 C CD . LYS A 1 79 ? 0.688 80.294 -12.120 1.00 39.60 ? 79 LYS A CD 1 ATOM 653 C CE . LYS A 1 79 ? 0.297 81.716 -12.476 1.00 43.16 ? 79 LYS A CE 1 ATOM 654 N NZ . LYS A 1 79 ? 1.330 82.335 -13.359 1.00 45.64 ? 79 LYS A NZ 1 ATOM 655 N N . SER A 1 80 ? 2.610 75.044 -13.924 1.00 28.26 ? 80 SER A N 1 ATOM 656 C CA . SER A 1 80 ? 3.512 73.946 -13.572 1.00 26.08 ? 80 SER A CA 1 ATOM 657 C C . SER A 1 80 ? 2.749 72.643 -13.411 1.00 25.15 ? 80 SER A C 1 ATOM 658 O O . SER A 1 80 ? 1.539 72.641 -13.182 1.00 24.00 ? 80 SER A O 1 ATOM 659 C CB . SER A 1 80 ? 4.247 74.233 -12.252 1.00 26.43 ? 80 SER A CB 1 ATOM 660 O OG . SER A 1 80 ? 5.487 74.887 -12.456 1.00 25.41 ? 80 SER A OG 1 ATOM 661 N N . CYS A 1 81 ? 3.470 71.534 -13.529 1.00 24.72 ? 81 CYS A N 1 ATOM 662 C CA . CYS A 1 81 ? 2.882 70.212 -13.360 1.00 24.61 ? 81 CYS A CA 1 ATOM 663 C C . CYS A 1 81 ? 3.616 69.550 -12.201 1.00 24.93 ? 81 CYS A C 1 ATOM 664 O O . CYS A 1 81 ? 4.702 68.993 -12.373 1.00 24.49 ? 81 CYS A O 1 ATOM 665 C CB . CYS A 1 81 ? 3.047 69.382 -14.632 1.00 25.21 ? 81 CYS A CB 1 ATOM 666 S SG . CYS A 1 81 ? 2.134 70.041 -16.045 1.00 26.99 ? 81 CYS A SG 1 ATOM 667 N N . TRP A 1 82 ? 3.026 69.625 -11.014 1.00 23.06 ? 82 TRP A N 1 ATOM 668 C CA . TRP A 1 82 ? 3.655 69.040 -9.847 1.00 23.75 ? 82 TRP A CA 1 ATOM 669 C C . TRP A 1 82 ? 3.326 67.556 -9.637 1.00 24.56 ? 82 TRP A C 1 ATOM 670 O O . TRP A 1 82 ? 2.682 66.931 -10.480 1.00 24.97 ? 82 TRP A O 1 ATOM 671 C CB . TRP A 1 82 ? 3.344 69.900 -8.616 1.00 20.46 ? 82 TRP A CB 1 ATOM 672 C CG . TRP A 1 82 ? 3.964 71.288 -8.750 1.00 20.99 ? 82 TRP A CG 1 ATOM 673 C CD1 . TRP A 1 82 ? 5.196 71.588 -9.280 1.00 20.48 ? 82 TRP A CD1 1 ATOM 674 C CD2 . TRP A 1 82 ? 3.397 72.543 -8.336 1.00 18.70 ? 82 TRP A CD2 1 ATOM 675 N NE1 . TRP A 1 82 ? 5.427 72.943 -9.216 1.00 20.57 ? 82 TRP A NE1 1 ATOM 676 C CE2 . TRP A 1 82 ? 4.342 73.553 -8.643 1.00 19.27 ? 82 TRP A CE2 1 ATOM 677 C CE3 . TRP A 1 82 ? 2.184 72.911 -7.733 1.00 17.37 ? 82 TRP A CE3 1 ATOM 678 C CZ2 . TRP A 1 82 ? 4.110 74.910 -8.369 1.00 20.13 ? 82 TRP A CZ2 1 ATOM 679 C CZ3 . TRP A 1 82 ? 1.953 74.261 -7.459 1.00 18.22 ? 82 TRP A CZ3 1 ATOM 680 C CH2 . TRP A 1 82 ? 2.914 75.243 -7.778 1.00 19.36 ? 82 TRP A CH2 1 ATOM 681 N N . SER A 1 83 ? 3.786 67.001 -8.521 1.00 23.06 ? 83 SER A N 1 ATOM 682 C CA . SER A 1 83 ? 3.631 65.580 -8.214 1.00 22.68 ? 83 SER A CA 1 ATOM 683 C C . SER A 1 83 ? 2.293 64.879 -8.405 1.00 22.26 ? 83 SER A C 1 ATOM 684 O O . SER A 1 83 ? 1.222 65.462 -8.226 1.00 23.71 ? 83 SER A O 1 ATOM 685 C CB . SER A 1 83 ? 4.149 65.311 -6.800 1.00 21.52 ? 83 SER A CB 1 ATOM 686 O OG . SER A 1 83 ? 5.532 65.598 -6.737 1.00 19.43 ? 83 SER A OG 1 ATOM 687 N N . GLY A 1 84 ? 2.384 63.600 -8.761 1.00 21.28 ? 84 GLY A N 1 ATOM 688 C CA . GLY A 1 84 ? 1.205 62.787 -8.988 1.00 21.89 ? 84 GLY A CA 1 ATOM 689 C C . GLY A 1 84 ? 1.538 61.305 -9.004 1.00 22.80 ? 84 GLY A C 1 ATOM 690 O O . GLY A 1 84 ? 2.699 60.919 -8.846 1.00 21.92 ? 84 GLY A O 1 ATOM 691 N N . SER A 1 85 ? 0.524 60.473 -9.216 1.00 22.30 ? 85 SER A N 1 ATOM 692 C CA . SER A 1 85 ? 0.712 59.030 -9.216 1.00 22.86 ? 85 SER A CA 1 ATOM 693 C C . SER A 1 85 ? 0.010 58.332 -10.376 1.00 23.90 ? 85 SER A C 1 ATOM 694 O O . SER A 1 85 ? -0.881 58.896 -11.013 1.00 25.11 ? 85 SER A O 1 ATOM 695 C CB . SER A 1 85 ? 0.206 58.453 -7.893 1.00 22.42 ? 85 SER A CB 1 ATOM 696 O OG . SER A 1 85 ? 0.748 59.168 -6.797 1.00 22.69 ? 85 SER A OG 1 ATOM 697 N N . ALA A 1 86 ? 0.417 57.093 -10.630 1.00 23.54 ? 86 ALA A N 1 ATOM 698 C CA . ALA A 1 86 ? -0.144 56.297 -11.711 1.00 23.02 ? 86 ALA A CA 1 ATOM 699 C C . ALA A 1 86 ? -1.027 55.167 -11.208 1.00 23.02 ? 86 ALA A C 1 ATOM 700 O O . ALA A 1 86 ? -0.692 54.483 -10.239 1.00 23.86 ? 86 ALA A O 1 ATOM 701 C CB . ALA A 1 86 ? 0.981 55.717 -12.555 1.00 23.80 ? 86 ALA A CB 1 ATOM 702 N N . THR A 1 87 ? -2.154 54.974 -11.880 1.00 22.21 ? 87 THR A N 1 ATOM 703 C CA . THR A 1 87 ? -3.085 53.902 -11.550 1.00 22.01 ? 87 THR A CA 1 ATOM 704 C C . THR A 1 87 ? -3.485 53.242 -12.869 1.00 23.03 ? 87 THR A C 1 ATOM 705 O O . THR A 1 87 ? -4.010 53.905 -13.762 1.00 24.24 ? 87 THR A O 1 ATOM 706 C CB . THR A 1 87 ? -4.363 54.433 -10.878 1.00 22.50 ? 87 THR A CB 1 ATOM 707 O OG1 . THR A 1 87 ? -4.018 55.180 -9.707 1.00 23.12 ? 87 THR A OG1 1 ATOM 708 C CG2 . THR A 1 87 ? -5.279 53.270 -10.486 1.00 21.35 ? 87 THR A CG2 1 ATOM 709 N N . ILE A 1 88 ? -3.223 51.949 -13.005 1.00 22.63 ? 88 ILE A N 1 ATOM 710 C CA . ILE A 1 88 ? -3.585 51.246 -14.229 1.00 23.43 ? 88 ILE A CA 1 ATOM 711 C C . ILE A 1 88 ? -4.995 50.688 -14.048 1.00 23.76 ? 88 ILE A C 1 ATOM 712 O O . ILE A 1 88 ? -5.212 49.738 -13.293 1.00 24.65 ? 88 ILE A O 1 ATOM 713 C CB . ILE A 1 88 ? -2.584 50.108 -14.533 1.00 23.74 ? 88 ILE A CB 1 ATOM 714 C CG1 . ILE A 1 88 ? -1.176 50.699 -14.677 1.00 22.72 ? 88 ILE A CG1 1 ATOM 715 C CG2 . ILE A 1 88 ? -2.984 49.384 -15.819 1.00 22.31 ? 88 ILE A CG2 1 ATOM 716 C CD1 . ILE A 1 88 ? -0.083 49.676 -14.856 1.00 24.30 ? 88 ILE A CD1 1 ATOM 717 N N . LEU A 1 89 ? -5.952 51.303 -14.738 1.00 22.91 ? 89 LEU A N 1 ATOM 718 C CA . LEU A 1 89 ? -7.354 50.914 -14.644 1.00 22.83 ? 89 LEU A CA 1 ATOM 719 C C . LEU A 1 89 ? -7.660 49.669 -15.459 1.00 23.52 ? 89 LEU A C 1 ATOM 720 O O . LEU A 1 89 ? -6.932 49.336 -16.395 1.00 23.02 ? 89 LEU A O 1 ATOM 721 C CB . LEU A 1 89 ? -8.250 52.052 -15.147 1.00 20.29 ? 89 LEU A CB 1 ATOM 722 C CG . LEU A 1 89 ? -7.918 53.484 -14.716 1.00 20.93 ? 89 LEU A CG 1 ATOM 723 C CD1 . LEU A 1 89 ? -8.867 54.458 -15.409 1.00 17.48 ? 89 LEU A CD1 1 ATOM 724 C CD2 . LEU A 1 89 ? -8.019 53.606 -13.205 1.00 18.89 ? 89 LEU A CD2 1 ATOM 725 N N . PRO A 1 90 ? -8.737 48.952 -15.099 1.00 23.89 ? 90 PRO A N 1 ATOM 726 C CA . PRO A 1 90 ? -9.107 47.747 -15.846 1.00 22.66 ? 90 PRO A CA 1 ATOM 727 C C . PRO A 1 90 ? -9.233 48.179 -17.304 1.00 23.21 ? 90 PRO A C 1 ATOM 728 O O . PRO A 1 90 ? -9.659 49.302 -17.583 1.00 22.12 ? 90 PRO A O 1 ATOM 729 C CB . PRO A 1 90 ? -10.445 47.368 -15.227 1.00 21.57 ? 90 PRO A CB 1 ATOM 730 C CG . PRO A 1 90 ? -10.239 47.735 -13.791 1.00 23.01 ? 90 PRO A CG 1 ATOM 731 C CD . PRO A 1 90 ? -9.585 49.108 -13.903 1.00 24.70 ? 90 PRO A CD 1 ATOM 732 N N . GLY A 1 91 ? -8.864 47.301 -18.226 1.00 22.14 ? 91 GLY A N 1 ATOM 733 C CA . GLY A 1 91 ? -8.908 47.660 -19.629 1.00 24.63 ? 91 GLY A CA 1 ATOM 734 C C . GLY A 1 91 ? -7.488 48.021 -20.029 1.00 26.10 ? 91 GLY A C 1 ATOM 735 O O . GLY A 1 91 ? -7.188 48.291 -21.195 1.00 26.35 ? 91 GLY A O 1 ATOM 736 N N . ASN A 1 92 ? -6.616 48.044 -19.028 1.00 26.50 ? 92 ASN A N 1 ATOM 737 C CA . ASN A 1 92 ? -5.206 48.330 -19.219 1.00 26.91 ? 92 ASN A CA 1 ATOM 738 C C . ASN A 1 92 ? -4.879 49.762 -19.670 1.00 27.61 ? 92 ASN A C 1 ATOM 739 O O . ASN A 1 92 ? -4.157 49.958 -20.652 1.00 27.18 ? 92 ASN A O 1 ATOM 740 C CB . ASN A 1 92 ? -4.631 47.305 -20.204 1.00 27.99 ? 92 ASN A CB 1 ATOM 741 C CG . ASN A 1 92 ? -3.221 46.880 -19.853 1.00 30.44 ? 92 ASN A CG 1 ATOM 742 O OD1 . ASN A 1 92 ? -2.846 46.826 -18.680 1.00 30.61 ? 92 ASN A OD1 1 ATOM 743 N ND2 . ASN A 1 92 ? -2.433 46.551 -20.872 1.00 33.20 ? 92 ASN A ND2 1 ATOM 744 N N . ILE A 1 93 ? -5.410 50.758 -18.961 1.00 26.95 ? 93 ILE A N 1 ATOM 745 C CA . ILE A 1 93 ? -5.120 52.157 -19.284 1.00 28.05 ? 93 ILE A CA 1 ATOM 746 C C . ILE A 1 93 ? -4.415 52.820 -18.115 1.00 27.98 ? 93 ILE A C 1 ATOM 747 O O . ILE A 1 93 ? -4.955 52.868 -17.008 1.00 28.28 ? 93 ILE A O 1 ATOM 748 C CB . ILE A 1 93 ? -6.370 53.045 -19.517 1.00 28.78 ? 93 ILE A CB 1 ATOM 749 C CG1 . ILE A 1 93 ? -7.563 52.210 -19.941 1.00 32.94 ? 93 ILE A CG1 1 ATOM 750 C CG2 . ILE A 1 93 ? -6.043 54.128 -20.542 1.00 28.19 ? 93 ILE A CG2 1 ATOM 751 C CD1 . ILE A 1 93 ? -8.264 51.571 -18.768 1.00 40.41 ? 93 ILE A CD1 1 ATOM 752 N N . PRO A 1 94 ? -3.197 53.331 -18.337 1.00 26.44 ? 94 PRO A N 1 ATOM 753 C CA . PRO A 1 94 ? -2.505 53.989 -17.228 1.00 26.03 ? 94 PRO A CA 1 ATOM 754 C C . PRO A 1 94 ? -3.153 55.356 -17.045 1.00 26.23 ? 94 PRO A C 1 ATOM 755 O O . PRO A 1 94 ? -3.207 56.143 -17.988 1.00 27.41 ? 94 PRO A O 1 ATOM 756 C CB . PRO A 1 94 ? -1.069 54.110 -17.733 1.00 25.05 ? 94 PRO A CB 1 ATOM 757 C CG . PRO A 1 94 ? -0.946 52.963 -18.701 1.00 26.60 ? 94 PRO A CG 1 ATOM 758 C CD . PRO A 1 94 ? -2.263 53.030 -19.433 1.00 25.45 ? 94 PRO A CD 1 ATOM 759 N N . ALA A 1 95 ? -3.667 55.628 -15.850 1.00 25.62 ? 95 ALA A N 1 ATOM 760 C CA . ALA A 1 95 ? -4.293 56.916 -15.570 1.00 25.60 ? 95 ALA A CA 1 ATOM 761 C C . ALA A 1 95 ? -3.379 57.677 -14.622 1.00 26.11 ? 95 ALA A C 1 ATOM 762 O O . ALA A 1 95 ? -2.990 57.161 -13.571 1.00 27.03 ? 95 ALA A O 1 ATOM 763 C CB . ALA A 1 95 ? -5.662 56.716 -14.937 1.00 24.37 ? 95 ALA A CB 1 ATOM 764 N N . MET A 1 96 ? -3.037 58.905 -14.992 1.00 24.83 ? 96 MET A N 1 ATOM 765 C CA . MET A 1 96 ? -2.145 59.716 -14.179 1.00 24.29 ? 96 MET A CA 1 ATOM 766 C C . MET A 1 96 ? -2.875 60.889 -13.529 1.00 24.70 ? 96 MET A C 1 ATOM 767 O O . MET A 1 96 ? -3.503 61.700 -14.211 1.00 23.79 ? 96 MET A O 1 ATOM 768 C CB . MET A 1 96 ? -1.002 60.239 -15.052 1.00 24.75 ? 96 MET A CB 1 ATOM 769 C CG . MET A 1 96 ? 0.288 60.539 -14.309 1.00 27.66 ? 96 MET A CG 1 ATOM 770 S SD . MET A 1 96 ? 1.140 59.055 -13.705 1.00 28.41 ? 96 MET A SD 1 ATOM 771 C CE . MET A 1 96 ? 1.856 58.434 -15.209 1.00 25.46 ? 96 MET A CE 1 ATOM 772 N N . LEU A 1 97 ? -2.804 60.960 -12.204 1.00 24.92 ? 97 LEU A N 1 ATOM 773 C CA . LEU A 1 97 ? -3.418 62.049 -11.450 1.00 24.24 ? 97 LEU A CA 1 ATOM 774 C C . LEU A 1 97 ? -2.265 62.863 -10.883 1.00 23.87 ? 97 LEU A C 1 ATOM 775 O O . LEU A 1 97 ? -1.406 62.324 -10.195 1.00 25.24 ? 97 LEU A O 1 ATOM 776 C CB . LEU A 1 97 ? -4.268 61.512 -10.303 1.00 23.53 ? 97 LEU A CB 1 ATOM 777 C CG . LEU A 1 97 ? -5.537 60.756 -10.685 1.00 27.14 ? 97 LEU A CG 1 ATOM 778 C CD1 . LEU A 1 97 ? -6.234 60.259 -9.423 1.00 26.03 ? 97 LEU A CD1 1 ATOM 779 C CD2 . LEU A 1 97 ? -6.452 61.679 -11.480 1.00 28.44 ? 97 LEU A CD2 1 ATOM 780 N N . TYR A 1 98 ? -2.241 64.157 -11.173 1.00 23.47 ? 98 TYR A N 1 ATOM 781 C CA . TYR A 1 98 ? -1.167 65.007 -10.688 1.00 22.64 ? 98 TYR A CA 1 ATOM 782 C C . TYR A 1 98 ? -1.696 66.367 -10.278 1.00 22.98 ? 98 TYR A C 1 ATOM 783 O O . TYR A 1 98 ? -2.810 66.751 -10.636 1.00 23.06 ? 98 TYR A O 1 ATOM 784 C CB . TYR A 1 98 ? -0.107 65.172 -11.778 1.00 21.42 ? 98 TYR A CB 1 ATOM 785 C CG . TYR A 1 98 ? -0.605 65.905 -13.003 1.00 22.30 ? 98 TYR A CG 1 ATOM 786 C CD1 . TYR A 1 98 ? -0.433 67.284 -13.134 1.00 22.56 ? 98 TYR A CD1 1 ATOM 787 C CD2 . TYR A 1 98 ? -1.267 65.224 -14.027 1.00 23.82 ? 98 TYR A CD2 1 ATOM 788 C CE1 . TYR A 1 98 ? -0.905 67.971 -14.253 1.00 22.63 ? 98 TYR A CE1 1 ATOM 789 C CE2 . TYR A 1 98 ? -1.745 65.900 -15.154 1.00 24.49 ? 98 TYR A CE2 1 ATOM 790 C CZ . TYR A 1 98 ? -1.561 67.274 -15.259 1.00 25.15 ? 98 TYR A CZ 1 ATOM 791 O OH . TYR A 1 98 ? -2.036 67.950 -16.364 1.00 26.86 ? 98 TYR A OH 1 ATOM 792 N N . THR A 1 99 ? -0.891 67.094 -9.515 1.00 23.58 ? 99 THR A N 1 ATOM 793 C CA . THR A 1 99 ? -1.280 68.418 -9.072 1.00 22.83 ? 99 THR A CA 1 ATOM 794 C C . THR A 1 99 ? -0.765 69.450 -10.051 1.00 23.11 ? 99 THR A C 1 ATOM 795 O O . THR A 1 99 ? 0.426 69.494 -10.352 1.00 24.26 ? 99 THR A O 1 ATOM 796 C CB . THR A 1 99 ? -0.693 68.762 -7.705 1.00 21.37 ? 99 THR A CB 1 ATOM 797 O OG1 . THR A 1 99 ? -1.176 67.835 -6.727 1.00 23.71 ? 99 THR A OG1 1 ATOM 798 C CG2 . THR A 1 99 ? -1.090 70.182 -7.311 1.00 19.24 ? 99 THR A CG2 1 ATOM 799 N N . GLY A 1 100 ? -1.668 70.277 -10.554 1.00 22.58 ? 100 GLY A N 1 ATOM 800 C CA . GLY A 1 100 ? -1.255 71.316 -11.469 1.00 23.33 ? 100 GLY A CA 1 ATOM 801 C C . GLY A 1 100 ? -1.408 72.660 -10.785 1.00 25.05 ? 100 GLY A C 1 ATOM 802 O O . GLY A 1 100 ? -2.198 72.807 -9.845 1.00 24.74 ? 100 GLY A O 1 ATOM 803 N N . SER A 1 101 ? -0.628 73.635 -11.231 1.00 25.33 ? 101 SER A N 1 ATOM 804 C CA . SER A 1 101 ? -0.708 74.985 -10.694 1.00 27.46 ? 101 SER A CA 1 ATOM 805 C C . SER A 1 101 ? -1.441 75.744 -11.803 1.00 28.51 ? 101 SER A C 1 ATOM 806 O O . SER A 1 101 ? -0.858 76.012 -12.856 1.00 28.25 ? 101 SER A O 1 ATOM 807 C CB . SER A 1 101 ? 0.704 75.545 -10.482 1.00 27.08 ? 101 SER A CB 1 ATOM 808 O OG . SER A 1 101 ? 0.673 76.847 -9.925 1.00 29.33 ? 101 SER A OG 1 ATOM 809 N N . ASP A 1 102 ? -2.716 76.067 -11.588 1.00 29.17 ? 102 ASP A N 1 ATOM 810 C CA . ASP A 1 102 ? -3.486 76.753 -12.625 1.00 31.74 ? 102 ASP A CA 1 ATOM 811 C C . ASP A 1 102 ? -3.144 78.227 -12.811 1.00 32.95 ? 102 ASP A C 1 ATOM 812 O O . ASP A 1 102 ? -2.266 78.760 -12.129 1.00 33.94 ? 102 ASP A O 1 ATOM 813 C CB . ASP A 1 102 ? -5.002 76.585 -12.404 1.00 32.74 ? 102 ASP A CB 1 ATOM 814 C CG . ASP A 1 102 ? -5.516 77.321 -11.181 1.00 33.84 ? 102 ASP A CG 1 ATOM 815 O OD1 . ASP A 1 102 ? -4.881 78.304 -10.747 1.00 33.08 ? 102 ASP A OD1 1 ATOM 816 O OD2 . ASP A 1 102 ? -6.583 76.920 -10.665 1.00 34.03 ? 102 ASP A OD2 1 ATOM 817 N N . SER A 1 103 ? -3.836 78.875 -13.749 1.00 33.97 ? 103 SER A N 1 ATOM 818 C CA . SER A 1 103 ? -3.598 80.282 -14.061 1.00 35.52 ? 103 SER A CA 1 ATOM 819 C C . SER A 1 103 ? -3.765 81.218 -12.867 1.00 36.41 ? 103 SER A C 1 ATOM 820 O O . SER A 1 103 ? -3.218 82.318 -12.862 1.00 37.36 ? 103 SER A O 1 ATOM 821 C CB . SER A 1 103 ? -4.509 80.730 -15.206 1.00 35.40 ? 103 SER A CB 1 ATOM 822 O OG . SER A 1 103 ? -5.876 80.618 -14.851 1.00 37.04 ? 103 SER A OG 1 ATOM 823 N N . LYS A 1 104 ? -4.518 80.781 -11.859 1.00 37.75 ? 104 LYS A N 1 ATOM 824 C CA . LYS A 1 104 ? -4.734 81.579 -10.653 1.00 38.71 ? 104 LYS A CA 1 ATOM 825 C C . LYS A 1 104 ? -3.830 81.088 -9.523 1.00 38.73 ? 104 LYS A C 1 ATOM 826 O O . LYS A 1 104 ? -4.047 81.402 -8.348 1.00 38.48 ? 104 LYS A O 1 ATOM 827 C CB . LYS A 1 104 ? -6.196 81.496 -10.206 1.00 41.60 ? 104 LYS A CB 1 ATOM 828 C CG . LYS A 1 104 ? -7.173 82.117 -11.184 1.00 46.82 ? 104 LYS A CG 1 ATOM 829 C CD . LYS A 1 104 ? -8.592 82.085 -10.642 1.00 51.99 ? 104 LYS A CD 1 ATOM 830 C CE . LYS A 1 104 ? -9.582 82.668 -11.649 1.00 55.89 ? 104 LYS A CE 1 ATOM 831 N NZ . LYS A 1 104 ? -10.988 82.645 -11.142 1.00 57.47 ? 104 LYS A NZ 1 ATOM 832 N N . SER A 1 105 ? -2.822 80.305 -9.889 1.00 37.35 ? 105 SER A N 1 ATOM 833 C CA . SER A 1 105 ? -1.878 79.769 -8.923 1.00 36.24 ? 105 SER A CA 1 ATOM 834 C C . SER A 1 105 ? -2.504 78.854 -7.875 1.00 34.40 ? 105 SER A C 1 ATOM 835 O O . SER A 1 105 ? -2.019 78.774 -6.750 1.00 35.09 ? 105 SER A O 1 ATOM 836 C CB . SER A 1 105 ? -1.136 80.913 -8.228 1.00 36.88 ? 105 SER A CB 1 ATOM 837 O OG . SER A 1 105 ? -0.347 81.638 -9.156 1.00 40.16 ? 105 SER A OG 1 ATOM 838 N N . ARG A 1 106 ? -3.587 78.174 -8.230 1.00 32.87 ? 106 ARG A N 1 ATOM 839 C CA . ARG A 1 106 ? -4.215 77.243 -7.295 1.00 32.71 ? 106 ARG A CA 1 ATOM 840 C C . ARG A 1 106 ? -3.670 75.838 -7.541 1.00 30.32 ? 106 ARG A C 1 ATOM 841 O O . ARG A 1 106 ? -3.355 75.474 -8.672 1.00 29.96 ? 106 ARG A O 1 ATOM 842 C CB . ARG A 1 106 ? -5.728 77.178 -7.494 1.00 34.43 ? 106 ARG A CB 1 ATOM 843 C CG . ARG A 1 106 ? -6.524 78.346 -6.988 1.00 38.26 ? 106 ARG A CG 1 ATOM 844 C CD . ARG A 1 106 ? -8.002 77.975 -7.002 1.00 41.08 ? 106 ARG A CD 1 ATOM 845 N NE . ARG A 1 106 ? -8.427 77.499 -8.319 1.00 42.92 ? 106 ARG A NE 1 ATOM 846 C CZ . ARG A 1 106 ? -9.608 76.939 -8.567 1.00 43.52 ? 106 ARG A CZ 1 ATOM 847 N NH1 . ARG A 1 106 ? -10.486 76.781 -7.583 1.00 42.68 ? 106 ARG A NH1 1 ATOM 848 N NH2 . ARG A 1 106 ? -9.912 76.539 -9.796 1.00 41.94 ? 106 ARG A NH2 1 ATOM 849 N N . GLN A 1 107 ? -3.558 75.050 -6.481 1.00 27.90 ? 107 GLN A N 1 ATOM 850 C CA . GLN A 1 107 ? -3.100 73.681 -6.629 1.00 26.22 ? 107 GLN A CA 1 ATOM 851 C C . GLN A 1 107 ? -4.374 72.880 -6.843 1.00 26.06 ? 107 GLN A C 1 ATOM 852 O O . GLN A 1 107 ? -5.248 72.841 -5.977 1.00 26.00 ? 107 GLN A O 1 ATOM 853 C CB . GLN A 1 107 ? -2.349 73.223 -5.376 1.00 24.05 ? 107 GLN A CB 1 ATOM 854 C CG . GLN A 1 107 ? -1.134 74.105 -5.081 1.00 25.51 ? 107 GLN A CG 1 ATOM 855 C CD . GLN A 1 107 ? -0.278 73.615 -3.928 1.00 24.73 ? 107 GLN A CD 1 ATOM 856 O OE1 . GLN A 1 107 ? -0.729 72.847 -3.076 1.00 25.44 ? 107 GLN A OE1 1 ATOM 857 N NE2 . GLN A 1 107 ? 0.967 74.077 -3.888 1.00 24.55 ? 107 GLN A NE2 1 ATOM 858 N N . VAL A 1 108 ? -4.483 72.275 -8.022 1.00 24.87 ? 108 VAL A N 1 ATOM 859 C CA . VAL A 1 108 ? -5.655 71.495 -8.393 1.00 24.44 ? 108 VAL A CA 1 ATOM 860 C C . VAL A 1 108 ? -5.228 70.141 -8.958 1.00 25.59 ? 108 VAL A C 1 ATOM 861 O O . VAL A 1 108 ? -4.132 70.007 -9.510 1.00 26.76 ? 108 VAL A O 1 ATOM 862 C CB . VAL A 1 108 ? -6.494 72.259 -9.446 1.00 24.70 ? 108 VAL A CB 1 ATOM 863 C CG1 . VAL A 1 108 ? -6.964 73.594 -8.869 1.00 21.92 ? 108 VAL A CG1 1 ATOM 864 C CG2 . VAL A 1 108 ? -5.660 72.503 -10.698 1.00 22.81 ? 108 VAL A CG2 1 ATOM 865 N N . GLN A 1 109 ? -6.091 69.139 -8.826 1.00 23.81 ? 109 GLN A N 1 ATOM 866 C CA . GLN A 1 109 ? -5.764 67.802 -9.304 1.00 24.54 ? 109 GLN A CA 1 ATOM 867 C C . GLN A 1 109 ? -6.271 67.552 -10.719 1.00 25.44 ? 109 GLN A C 1 ATOM 868 O O . GLN A 1 109 ? -7.471 67.670 -10.997 1.00 25.83 ? 109 GLN A O 1 ATOM 869 C CB . GLN A 1 109 ? -6.327 66.765 -8.332 1.00 24.30 ? 109 GLN A CB 1 ATOM 870 C CG . GLN A 1 109 ? -6.156 67.179 -6.876 1.00 24.88 ? 109 GLN A CG 1 ATOM 871 C CD . GLN A 1 109 ? -4.785 67.779 -6.601 1.00 25.70 ? 109 GLN A CD 1 ATOM 872 O OE1 . GLN A 1 109 ? -4.667 68.799 -5.914 1.00 24.22 ? 109 GLN A OE1 1 ATOM 873 N NE2 . GLN A 1 109 ? -3.741 67.149 -7.139 1.00 22.81 ? 109 GLN A NE2 1 ATOM 874 N N . ASP A 1 110 ? -5.340 67.195 -11.602 1.00 24.35 ? 110 ASP A N 1 ATOM 875 C CA . ASP A 1 110 ? -5.634 66.945 -13.009 1.00 23.44 ? 110 ASP A CA 1 ATOM 876 C C . ASP A 1 110 ? -5.415 65.488 -13.415 1.00 23.81 ? 110 ASP A C 1 ATOM 877 O O . ASP A 1 110 ? -4.680 64.746 -12.758 1.00 22.56 ? 110 ASP A O 1 ATOM 878 C CB . ASP A 1 110 ? -4.758 67.852 -13.874 1.00 23.96 ? 110 ASP A CB 1 ATOM 879 C CG . ASP A 1 110 ? -4.969 69.326 -13.574 1.00 24.32 ? 110 ASP A CG 1 ATOM 880 O OD1 . ASP A 1 110 ? -4.000 70.105 -13.696 1.00 24.60 ? 110 ASP A OD1 1 ATOM 881 O OD2 . ASP A 1 110 ? -6.106 69.708 -13.224 1.00 25.12 ? 110 ASP A OD2 1 ATOM 882 N N . LEU A 1 111 ? -6.040 65.100 -14.524 1.00 23.92 ? 111 LEU A N 1 ATOM 883 C CA . LEU A 1 111 ? -5.951 63.739 -15.043 1.00 23.94 ? 111 LEU A CA 1 ATOM 884 C C . LEU A 1 111 ? -5.387 63.700 -16.466 1.00 25.12 ? 111 LEU A C 1 ATOM 885 O O . LEU A 1 111 ? -5.664 64.577 -17.288 1.00 25.45 ? 111 LEU A O 1 ATOM 886 C CB . LEU A 1 111 ? -7.347 63.103 -14.998 1.00 24.76 ? 111 LEU A CB 1 ATOM 887 C CG . LEU A 1 111 ? -7.713 61.663 -15.390 1.00 27.19 ? 111 LEU A CG 1 ATOM 888 C CD1 . LEU A 1 111 ? -8.277 61.665 -16.781 1.00 26.53 ? 111 LEU A CD1 1 ATOM 889 C CD2 . LEU A 1 111 ? -6.518 60.729 -15.267 1.00 25.57 ? 111 LEU A CD2 1 ATOM 890 N N . ALA A 1 112 ? -4.581 62.682 -16.746 1.00 24.47 ? 112 ALA A N 1 ATOM 891 C CA . ALA A 1 112 ? -3.990 62.505 -18.067 1.00 23.84 ? 112 ALA A CA 1 ATOM 892 C C . ALA A 1 112 ? -3.755 61.019 -18.289 1.00 23.60 ? 112 ALA A C 1 ATOM 893 O O . ALA A 1 112 ? -3.678 60.249 -17.331 1.00 24.69 ? 112 ALA A O 1 ATOM 894 C CB . ALA A 1 112 ? -2.668 63.267 -18.170 1.00 22.06 ? 112 ALA A CB 1 ATOM 895 N N . TRP A 1 113 ? -3.656 60.612 -19.548 1.00 22.71 ? 113 TRP A N 1 ATOM 896 C CA . TRP A 1 113 ? -3.401 59.213 -19.864 1.00 23.34 ? 113 TRP A CA 1 ATOM 897 C C . TRP A 1 113 ? -2.690 59.121 -21.205 1.00 22.51 ? 113 TRP A C 1 ATOM 898 O O . TRP A 1 113 ? -2.699 60.074 -21.984 1.00 22.29 ? 113 TRP A O 1 ATOM 899 C CB . TRP A 1 113 ? -4.712 58.404 -19.847 1.00 23.22 ? 113 TRP A CB 1 ATOM 900 C CG . TRP A 1 113 ? -5.708 58.730 -20.919 1.00 26.27 ? 113 TRP A CG 1 ATOM 901 C CD1 . TRP A 1 113 ? -5.861 58.089 -22.116 1.00 27.61 ? 113 TRP A CD1 1 ATOM 902 C CD2 . TRP A 1 113 ? -6.715 59.753 -20.881 1.00 27.44 ? 113 TRP A CD2 1 ATOM 903 N NE1 . TRP A 1 113 ? -6.902 58.646 -22.824 1.00 29.55 ? 113 TRP A NE1 1 ATOM 904 C CE2 . TRP A 1 113 ? -7.443 59.669 -22.090 1.00 28.02 ? 113 TRP A CE2 1 ATOM 905 C CE3 . TRP A 1 113 ? -7.073 60.733 -19.942 1.00 26.46 ? 113 TRP A CE3 1 ATOM 906 C CZ2 . TRP A 1 113 ? -8.510 60.528 -22.387 1.00 27.27 ? 113 TRP A CZ2 1 ATOM 907 C CZ3 . TRP A 1 113 ? -8.134 61.587 -20.236 1.00 26.96 ? 113 TRP A CZ3 1 ATOM 908 C CH2 . TRP A 1 113 ? -8.839 61.477 -21.453 1.00 27.43 ? 113 TRP A CH2 1 ATOM 909 N N . PRO A 1 114 ? -2.033 57.985 -21.483 1.00 23.98 ? 114 PRO A N 1 ATOM 910 C CA . PRO A 1 114 ? -1.317 57.823 -22.752 1.00 23.88 ? 114 PRO A CA 1 ATOM 911 C C . PRO A 1 114 ? -2.223 58.009 -23.962 1.00 24.88 ? 114 PRO A C 1 ATOM 912 O O . PRO A 1 114 ? -3.362 57.541 -23.974 1.00 25.24 ? 114 PRO A O 1 ATOM 913 C CB . PRO A 1 114 ? -0.765 56.402 -22.661 1.00 23.54 ? 114 PRO A CB 1 ATOM 914 C CG . PRO A 1 114 ? -0.615 56.185 -21.178 1.00 24.83 ? 114 PRO A CG 1 ATOM 915 C CD . PRO A 1 114 ? -1.897 56.777 -20.651 1.00 24.64 ? 114 PRO A CD 1 ATOM 916 N N . LYS A 1 115 ? -1.710 58.684 -24.982 1.00 25.23 ? 115 LYS A N 1 ATOM 917 C CA . LYS A 1 115 ? -2.485 58.919 -26.187 1.00 26.76 ? 115 LYS A CA 1 ATOM 918 C C . LYS A 1 115 ? -2.215 57.857 -27.256 1.00 26.61 ? 115 LYS A C 1 ATOM 919 O O . LYS A 1 115 ? -2.917 57.791 -28.263 1.00 28.41 ? 115 LYS A O 1 ATOM 920 C CB . LYS A 1 115 ? -2.167 60.306 -26.752 1.00 27.89 ? 115 LYS A CB 1 ATOM 921 C CG . LYS A 1 115 ? -3.205 60.784 -27.747 1.00 32.43 ? 115 LYS A CG 1 ATOM 922 C CD . LYS A 1 115 ? -2.936 62.194 -28.229 1.00 34.34 ? 115 LYS A CD 1 ATOM 923 C CE . LYS A 1 115 ? -1.783 62.242 -29.205 1.00 34.16 ? 115 LYS A CE 1 ATOM 924 N NZ . LYS A 1 115 ? -1.705 63.588 -29.829 1.00 37.42 ? 115 LYS A NZ 1 ATOM 925 N N . ASN A 1 116 ? -1.207 57.022 -27.027 1.00 25.67 ? 116 ASN A N 1 ATOM 926 C CA . ASN A 1 116 ? -0.827 55.986 -27.985 1.00 24.39 ? 116 ASN A CA 1 ATOM 927 C C . ASN A 1 116 ? -0.357 54.732 -27.247 1.00 24.69 ? 116 ASN A C 1 ATOM 928 O O . ASN A 1 116 ? 0.845 54.506 -27.078 1.00 23.14 ? 116 ASN A O 1 ATOM 929 C CB . ASN A 1 116 ? 0.287 56.537 -28.878 1.00 23.92 ? 116 ASN A CB 1 ATOM 930 C CG . ASN A 1 116 ? 0.775 55.542 -29.917 1.00 27.42 ? 116 ASN A CG 1 ATOM 931 O OD1 . ASN A 1 116 ? 0.214 54.457 -30.092 1.00 25.64 ? 116 ASN A OD1 1 ATOM 932 N ND2 . ASN A 1 116 ? 1.835 55.940 -30.616 1.00 28.64 ? 116 ASN A ND2 1 ATOM 933 N N . LEU A 1 117 ? -1.313 53.916 -26.813 1.00 24.15 ? 117 LEU A N 1 ATOM 934 C CA . LEU A 1 117 ? -0.994 52.702 -26.076 1.00 25.72 ? 117 LEU A CA 1 ATOM 935 C C . LEU A 1 117 ? -0.179 51.681 -26.857 1.00 27.30 ? 117 LEU A C 1 ATOM 936 O O . LEU A 1 117 ? 0.298 50.705 -26.281 1.00 29.88 ? 117 LEU A O 1 ATOM 937 C CB . LEU A 1 117 ? -2.271 52.041 -25.552 1.00 24.30 ? 117 LEU A CB 1 ATOM 938 C CG . LEU A 1 117 ? -3.045 52.808 -24.472 1.00 25.04 ? 117 LEU A CG 1 ATOM 939 C CD1 . LEU A 1 117 ? -4.190 51.939 -23.975 1.00 26.03 ? 117 LEU A CD1 1 ATOM 940 C CD2 . LEU A 1 117 ? -2.125 53.171 -23.311 1.00 22.74 ? 117 LEU A CD2 1 ATOM 941 N N . SER A 1 118 ? -0.012 51.888 -28.158 1.00 28.08 ? 118 SER A N 1 ATOM 942 C CA . SER A 1 118 ? 0.774 50.941 -28.941 1.00 29.24 ? 118 SER A CA 1 ATOM 943 C C . SER A 1 118 ? 2.257 51.287 -28.811 1.00 27.94 ? 118 SER A C 1 ATOM 944 O O . SER A 1 118 ? 3.123 50.517 -29.222 1.00 29.08 ? 118 SER A O 1 ATOM 945 C CB . SER A 1 118 ? 0.355 50.960 -30.414 1.00 29.68 ? 118 SER A CB 1 ATOM 946 O OG . SER A 1 118 ? 0.781 52.148 -31.049 1.00 33.54 ? 118 SER A OG 1 ATOM 947 N N . ASP A 1 119 ? 2.544 52.454 -28.245 1.00 26.44 ? 119 ASP A N 1 ATOM 948 C CA . ASP A 1 119 ? 3.924 52.878 -28.033 1.00 25.69 ? 119 ASP A CA 1 ATOM 949 C C . ASP A 1 119 ? 4.392 52.288 -26.699 1.00 24.86 ? 119 ASP A C 1 ATOM 950 O O . ASP A 1 119 ? 3.935 52.701 -25.635 1.00 25.57 ? 119 ASP A O 1 ATOM 951 C CB . ASP A 1 119 ? 4.012 54.407 -27.989 1.00 25.53 ? 119 ASP A CB 1 ATOM 952 C CG . ASP A 1 119 ? 5.391 54.902 -27.581 1.00 26.00 ? 119 ASP A CG 1 ATOM 953 O OD1 . ASP A 1 119 ? 6.329 54.078 -27.535 1.00 25.07 ? 119 ASP A OD1 1 ATOM 954 O OD2 . ASP A 1 119 ? 5.539 56.115 -27.315 1.00 26.61 ? 119 ASP A OD2 1 ATOM 955 N N . PRO A 1 120 ? 5.308 51.309 -26.742 1.00 24.22 ? 120 PRO A N 1 ATOM 956 C CA . PRO A 1 120 ? 5.806 50.687 -25.512 1.00 23.90 ? 120 PRO A CA 1 ATOM 957 C C . PRO A 1 120 ? 6.417 51.662 -24.514 1.00 23.75 ? 120 PRO A C 1 ATOM 958 O O . PRO A 1 120 ? 6.486 51.365 -23.322 1.00 22.95 ? 120 PRO A O 1 ATOM 959 C CB . PRO A 1 120 ? 6.816 49.657 -26.026 1.00 24.91 ? 120 PRO A CB 1 ATOM 960 C CG . PRO A 1 120 ? 7.289 50.251 -27.319 1.00 25.13 ? 120 PRO A CG 1 ATOM 961 C CD . PRO A 1 120 ? 6.010 50.775 -27.922 1.00 25.06 ? 120 PRO A CD 1 ATOM 962 N N . PHE A 1 121 ? 6.846 52.826 -24.994 1.00 23.43 ? 121 PHE A N 1 ATOM 963 C CA . PHE A 1 121 ? 7.450 53.823 -24.118 1.00 23.13 ? 121 PHE A CA 1 ATOM 964 C C . PHE A 1 121 ? 6.492 54.920 -23.651 1.00 23.29 ? 121 PHE A C 1 ATOM 965 O O . PHE A 1 121 ? 6.882 55.797 -22.883 1.00 24.44 ? 121 PHE A O 1 ATOM 966 C CB . PHE A 1 121 ? 8.670 54.460 -24.798 1.00 22.81 ? 121 PHE A CB 1 ATOM 967 C CG . PHE A 1 121 ? 9.845 53.529 -24.949 1.00 22.41 ? 121 PHE A CG 1 ATOM 968 C CD1 . PHE A 1 121 ? 9.847 52.274 -24.343 1.00 22.75 ? 121 PHE A CD1 1 ATOM 969 C CD2 . PHE A 1 121 ? 10.957 53.912 -25.694 1.00 23.65 ? 121 PHE A CD2 1 ATOM 970 C CE1 . PHE A 1 121 ? 10.943 51.411 -24.478 1.00 22.50 ? 121 PHE A CE1 1 ATOM 971 C CE2 . PHE A 1 121 ? 12.060 53.059 -25.836 1.00 22.28 ? 121 PHE A CE2 1 ATOM 972 C CZ . PHE A 1 121 ? 12.053 51.808 -25.227 1.00 21.16 ? 121 PHE A CZ 1 ATOM 973 N N . LEU A 1 122 ? 5.247 54.878 -24.113 1.00 22.64 ? 122 LEU A N 1 ATOM 974 C CA . LEU A 1 122 ? 4.250 55.875 -23.715 1.00 22.85 ? 122 LEU A CA 1 ATOM 975 C C . LEU A 1 122 ? 4.810 57.299 -23.678 1.00 23.21 ? 122 LEU A C 1 ATOM 976 O O . LEU A 1 122 ? 4.762 57.965 -22.641 1.00 23.54 ? 122 LEU A O 1 ATOM 977 C CB . LEU A 1 122 ? 3.691 55.526 -22.333 1.00 20.53 ? 122 LEU A CB 1 ATOM 978 C CG . LEU A 1 122 ? 3.113 54.117 -22.148 1.00 21.67 ? 122 LEU A CG 1 ATOM 979 C CD1 . LEU A 1 122 ? 2.603 53.969 -20.720 1.00 18.95 ? 122 LEU A CD1 1 ATOM 980 C CD2 . LEU A 1 122 ? 1.993 53.864 -23.155 1.00 17.52 ? 122 LEU A CD2 1 ATOM 981 N N . ARG A 1 123 ? 5.330 57.769 -24.805 1.00 23.18 ? 123 ARG A N 1 ATOM 982 C CA . ARG A 1 123 ? 5.904 59.110 -24.863 1.00 25.91 ? 123 ARG A CA 1 ATOM 983 C C . ARG A 1 123 ? 4.865 60.232 -24.831 1.00 26.46 ? 123 ARG A C 1 ATOM 984 O O . ARG A 1 123 ? 5.054 61.231 -24.142 1.00 26.59 ? 123 ARG A O 1 ATOM 985 C CB . ARG A 1 123 ? 6.746 59.271 -26.129 1.00 27.68 ? 123 ARG A CB 1 ATOM 986 C CG . ARG A 1 123 ? 7.853 58.251 -26.313 1.00 30.25 ? 123 ARG A CG 1 ATOM 987 C CD . ARG A 1 123 ? 8.408 58.367 -27.725 1.00 32.84 ? 123 ARG A CD 1 ATOM 988 N NE . ARG A 1 123 ? 9.239 57.230 -28.102 1.00 35.94 ? 123 ARG A NE 1 ATOM 989 C CZ . ARG A 1 123 ? 10.571 57.234 -28.103 1.00 40.54 ? 123 ARG A CZ 1 ATOM 990 N NH1 . ARG A 1 123 ? 11.245 58.327 -27.745 1.00 39.92 ? 123 ARG A NH1 1 ATOM 991 N NH2 . ARG A 1 123 ? 11.231 56.139 -28.466 1.00 39.79 ? 123 ARG A NH2 1 ATOM 992 N N . GLU A 1 124 ? 3.774 60.065 -25.575 1.00 26.38 ? 124 GLU A N 1 ATOM 993 C CA . GLU A 1 124 ? 2.736 61.091 -25.659 1.00 27.74 ? 124 GLU A CA 1 ATOM 994 C C . GLU A 1 124 ? 1.560 60.898 -24.707 1.00 26.90 ? 124 GLU A C 1 ATOM 995 O O . GLU A 1 124 ? 1.037 59.794 -24.559 1.00 27.14 ? 124 GLU A O 1 ATOM 996 C CB . GLU A 1 124 ? 2.207 61.176 -27.094 1.00 30.15 ? 124 GLU A CB 1 ATOM 997 C CG . GLU A 1 124 ? 3.265 61.483 -28.147 1.00 33.91 ? 124 GLU A CG 1 ATOM 998 C CD . GLU A 1 124 ? 4.009 62.775 -27.867 1.00 37.75 ? 124 GLU A CD 1 ATOM 999 O OE1 . GLU A 1 124 ? 3.349 63.770 -27.498 1.00 39.25 ? 124 GLU A OE1 1 ATOM 1000 O OE2 . GLU A 1 124 ? 5.250 62.801 -28.024 1.00 40.41 ? 124 GLU A OE2 1 ATOM 1001 N N . TRP A 1 125 ? 1.134 61.992 -24.083 1.00 24.82 ? 125 TRP A N 1 ATOM 1002 C CA . TRP A 1 125 ? 0.021 61.955 -23.138 1.00 25.15 ? 125 TRP A CA 1 ATOM 1003 C C . TRP A 1 125 ? -1.050 62.987 -23.472 1.00 24.78 ? 125 TRP A C 1 ATOM 1004 O O . TRP A 1 125 ? -0.749 64.064 -23.992 1.00 25.57 ? 125 TRP A O 1 ATOM 1005 C CB . TRP A 1 125 ? 0.539 62.189 -21.711 1.00 22.31 ? 125 TRP A CB 1 ATOM 1006 C CG . TRP A 1 125 ? 1.443 61.093 -21.243 1.00 21.77 ? 125 TRP A CG 1 ATOM 1007 C CD1 . TRP A 1 125 ? 2.685 60.786 -21.729 1.00 21.94 ? 125 TRP A CD1 1 ATOM 1008 C CD2 . TRP A 1 125 ? 1.137 60.093 -20.264 1.00 21.03 ? 125 TRP A CD2 1 ATOM 1009 N NE1 . TRP A 1 125 ? 3.168 59.648 -21.118 1.00 22.45 ? 125 TRP A NE1 1 ATOM 1010 C CE2 . TRP A 1 125 ? 2.237 59.203 -20.215 1.00 22.39 ? 125 TRP A CE2 1 ATOM 1011 C CE3 . TRP A 1 125 ? 0.039 59.858 -19.427 1.00 21.30 ? 125 TRP A CE3 1 ATOM 1012 C CZ2 . TRP A 1 125 ? 2.267 58.094 -19.363 1.00 20.73 ? 125 TRP A CZ2 1 ATOM 1013 C CZ3 . TRP A 1 125 ? 0.069 58.752 -18.578 1.00 21.32 ? 125 TRP A CZ3 1 ATOM 1014 C CH2 . TRP A 1 125 ? 1.177 57.884 -18.556 1.00 20.76 ? 125 TRP A CH2 1 ATOM 1015 N N . VAL A 1 126 ? -2.301 62.650 -23.174 1.00 23.00 ? 126 VAL A N 1 ATOM 1016 C CA . VAL A 1 126 ? -3.416 63.552 -23.433 1.00 22.57 ? 126 VAL A CA 1 ATOM 1017 C C . VAL A 1 126 ? -4.054 63.955 -22.098 1.00 22.14 ? 126 VAL A C 1 ATOM 1018 O O . VAL A 1 126 ? -4.142 63.141 -21.178 1.00 20.46 ? 126 VAL A O 1 ATOM 1019 C CB . VAL A 1 126 ? -4.472 62.879 -24.352 1.00 23.39 ? 126 VAL A CB 1 ATOM 1020 C CG1 . VAL A 1 126 ? -5.031 61.630 -23.689 1.00 23.74 ? 126 VAL A CG1 1 ATOM 1021 C CG2 . VAL A 1 126 ? -5.593 63.859 -24.666 1.00 26.17 ? 126 VAL A CG2 1 ATOM 1022 N N . LYS A 1 127 ? -4.478 65.213 -21.994 1.00 22.81 ? 127 LYS A N 1 ATOM 1023 C CA . LYS A 1 127 ? -5.096 65.731 -20.771 1.00 24.76 ? 127 LYS A CA 1 ATOM 1024 C C . LYS A 1 127 ? -6.611 65.618 -20.856 1.00 24.29 ? 127 LYS A C 1 ATOM 1025 O O . LYS A 1 127 ? -7.182 65.715 -21.939 1.00 24.44 ? 127 LYS A O 1 ATOM 1026 C CB . LYS A 1 127 ? -4.743 67.210 -20.566 1.00 25.68 ? 127 LYS A CB 1 ATOM 1027 C CG . LYS A 1 127 ? -3.265 67.555 -20.660 1.00 26.60 ? 127 LYS A CG 1 ATOM 1028 C CD . LYS A 1 127 ? -2.492 67.102 -19.441 1.00 25.66 ? 127 LYS A CD 1 ATOM 1029 C CE . LYS A 1 127 ? -1.009 67.454 -19.586 1.00 25.21 ? 127 LYS A CE 1 ATOM 1030 N NZ . LYS A 1 127 ? -0.775 68.923 -19.672 1.00 20.42 ? 127 LYS A NZ 1 ATOM 1031 N N . HIS A 1 128 ? -7.267 65.420 -19.717 1.00 24.84 ? 128 HIS A N 1 ATOM 1032 C CA . HIS A 1 128 ? -8.716 65.332 -19.721 1.00 25.89 ? 128 HIS A CA 1 ATOM 1033 C C . HIS A 1 128 ? -9.288 66.736 -19.892 1.00 27.39 ? 128 HIS A C 1 ATOM 1034 O O . HIS A 1 128 ? -8.865 67.674 -19.211 1.00 26.71 ? 128 HIS A O 1 ATOM 1035 C CB . HIS A 1 128 ? -9.251 64.736 -18.426 1.00 24.61 ? 128 HIS A CB 1 ATOM 1036 C CG . HIS A 1 128 ? -10.707 64.407 -18.497 1.00 27.05 ? 128 HIS A CG 1 ATOM 1037 N ND1 . HIS A 1 128 ? -11.171 63.159 -18.855 1.00 28.98 ? 128 HIS A ND1 1 ATOM 1038 C CD2 . HIS A 1 128 ? -11.803 65.190 -18.358 1.00 25.99 ? 128 HIS A CD2 1 ATOM 1039 C CE1 . HIS A 1 128 ? -12.490 63.187 -18.935 1.00 26.04 ? 128 HIS A CE1 1 ATOM 1040 N NE2 . HIS A 1 128 ? -12.897 64.408 -18.639 1.00 26.01 ? 128 HIS A NE2 1 ATOM 1041 N N . PRO A 1 129 ? -10.271 66.895 -20.798 1.00 28.49 ? 129 PRO A N 1 ATOM 1042 C CA . PRO A 1 129 ? -10.918 68.181 -21.084 1.00 28.03 ? 129 PRO A CA 1 ATOM 1043 C C . PRO A 1 129 ? -11.506 68.875 -19.860 1.00 29.17 ? 129 PRO A C 1 ATOM 1044 O O . PRO A 1 129 ? -11.575 70.101 -19.814 1.00 29.60 ? 129 PRO A O 1 ATOM 1045 C CB . PRO A 1 129 ? -11.998 67.807 -22.099 1.00 26.95 ? 129 PRO A CB 1 ATOM 1046 C CG . PRO A 1 129 ? -11.435 66.610 -22.775 1.00 26.88 ? 129 PRO A CG 1 ATOM 1047 C CD . PRO A 1 129 ? -10.868 65.829 -21.620 1.00 27.64 ? 129 PRO A CD 1 ATOM 1048 N N . LYS A 1 130 ? -11.923 68.093 -18.870 1.00 31.09 ? 130 LYS A N 1 ATOM 1049 C CA . LYS A 1 130 ? -12.521 68.652 -17.664 1.00 32.59 ? 130 LYS A CA 1 ATOM 1050 C C . LYS A 1 130 ? -11.565 69.026 -16.530 1.00 32.14 ? 130 LYS A C 1 ATOM 1051 O O . LYS A 1 130 ? -12.015 69.360 -15.433 1.00 31.15 ? 130 LYS A O 1 ATOM 1052 C CB . LYS A 1 130 ? -13.602 67.708 -17.131 1.00 35.85 ? 130 LYS A CB 1 ATOM 1053 C CG . LYS A 1 130 ? -14.844 67.654 -18.012 1.00 41.62 ? 130 LYS A CG 1 ATOM 1054 C CD . LYS A 1 130 ? -15.939 66.793 -17.390 1.00 46.90 ? 130 LYS A CD 1 ATOM 1055 C CE . LYS A 1 130 ? -17.215 66.825 -18.230 1.00 49.31 ? 130 LYS A CE 1 ATOM 1056 N NZ . LYS A 1 130 ? -18.243 65.858 -17.740 1.00 51.20 ? 130 LYS A NZ 1 ATOM 1057 N N . ASN A 1 131 ? -10.258 68.974 -16.773 1.00 30.69 ? 131 ASN A N 1 ATOM 1058 C CA . ASN A 1 131 ? -9.317 69.358 -15.726 1.00 30.67 ? 131 ASN A CA 1 ATOM 1059 C C . ASN A 1 131 ? -9.595 70.819 -15.366 1.00 31.12 ? 131 ASN A C 1 ATOM 1060 O O . ASN A 1 131 ? -9.862 71.642 -16.242 1.00 32.54 ? 131 ASN A O 1 ATOM 1061 C CB . ASN A 1 131 ? -7.864 69.212 -16.197 1.00 27.26 ? 131 ASN A CB 1 ATOM 1062 C CG . ASN A 1 131 ? -7.410 67.763 -16.261 1.00 26.72 ? 131 ASN A CG 1 ATOM 1063 O OD1 . ASN A 1 131 ? -7.920 66.911 -15.537 1.00 25.48 ? 131 ASN A OD1 1 ATOM 1064 N ND2 . ASN A 1 131 ? -6.433 67.483 -17.116 1.00 23.45 ? 131 ASN A ND2 1 ATOM 1065 N N . PRO A 1 132 ? -9.522 71.165 -14.071 1.00 30.93 ? 132 PRO A N 1 ATOM 1066 C CA . PRO A 1 132 ? -9.198 70.289 -12.940 1.00 30.08 ? 132 PRO A CA 1 ATOM 1067 C C . PRO A 1 132 ? -10.358 69.407 -12.489 1.00 30.10 ? 132 PRO A C 1 ATOM 1068 O O . PRO A 1 132 ? -11.515 69.831 -12.484 1.00 29.80 ? 132 PRO A O 1 ATOM 1069 C CB . PRO A 1 132 ? -8.789 71.278 -11.860 1.00 30.80 ? 132 PRO A CB 1 ATOM 1070 C CG . PRO A 1 132 ? -9.749 72.409 -12.109 1.00 30.98 ? 132 PRO A CG 1 ATOM 1071 C CD . PRO A 1 132 ? -9.679 72.560 -13.617 1.00 30.07 ? 132 PRO A CD 1 ATOM 1072 N N . LEU A 1 133 ? -10.034 68.180 -12.096 1.00 28.84 ? 133 LEU A N 1 ATOM 1073 C CA . LEU A 1 133 ? -11.030 67.230 -11.631 1.00 27.38 ? 133 LEU A CA 1 ATOM 1074 C C . LEU A 1 133 ? -11.377 67.456 -10.162 1.00 27.18 ? 133 LEU A C 1 ATOM 1075 O O . LEU A 1 133 ? -12.481 67.145 -9.721 1.00 26.85 ? 133 LEU A O 1 ATOM 1076 C CB . LEU A 1 133 ? -10.508 65.807 -11.822 1.00 26.93 ? 133 LEU A CB 1 ATOM 1077 C CG . LEU A 1 133 ? -10.930 65.030 -13.070 1.00 27.47 ? 133 LEU A CG 1 ATOM 1078 C CD1 . LEU A 1 133 ? -11.037 65.941 -14.276 1.00 24.42 ? 133 LEU A CD1 1 ATOM 1079 C CD2 . LEU A 1 133 ? -9.924 63.914 -13.295 1.00 24.54 ? 133 LEU A CD2 1 ATOM 1080 N N . ILE A 1 134 ? -10.426 67.994 -9.407 1.00 26.47 ? 134 ILE A N 1 ATOM 1081 C CA . ILE A 1 134 ? -10.628 68.254 -7.988 1.00 26.20 ? 134 ILE A CA 1 ATOM 1082 C C . ILE A 1 134 ? -9.942 69.560 -7.606 1.00 27.86 ? 134 ILE A C 1 ATOM 1083 O O . ILE A 1 134 ? -8.804 69.804 -8.001 1.00 29.64 ? 134 ILE A O 1 ATOM 1084 C CB . ILE A 1 134 ? -10.020 67.137 -7.120 1.00 24.85 ? 134 ILE A CB 1 ATOM 1085 C CG1 . ILE A 1 134 ? -10.467 65.768 -7.631 1.00 23.74 ? 134 ILE A CG1 1 ATOM 1086 C CG2 . ILE A 1 134 ? -10.449 67.318 -5.671 1.00 23.41 ? 134 ILE A CG2 1 ATOM 1087 C CD1 . ILE A 1 134 ? -9.869 64.599 -6.859 1.00 23.59 ? 134 ILE A CD1 1 ATOM 1088 N N . THR A 1 135 ? -10.636 70.397 -6.842 1.00 28.02 ? 135 THR A N 1 ATOM 1089 C CA . THR A 1 135 ? -10.072 71.668 -6.401 1.00 28.20 ? 135 THR A CA 1 ATOM 1090 C C . THR A 1 135 ? -10.080 71.722 -4.874 1.00 28.42 ? 135 THR A C 1 ATOM 1091 O O . THR A 1 135 ? -10.803 70.967 -4.224 1.00 27.12 ? 135 THR A O 1 ATOM 1092 C CB . THR A 1 135 ? -10.867 72.859 -6.964 1.00 29.31 ? 135 THR A CB 1 ATOM 1093 O OG1 . THR A 1 135 ? -12.238 72.751 -6.565 1.00 30.19 ? 135 THR A OG1 1 ATOM 1094 C CG2 . THR A 1 135 ? -10.774 72.887 -8.481 1.00 26.20 ? 135 THR A CG2 1 ATOM 1095 N N . PRO A 1 136 ? -9.273 72.617 -4.281 1.00 29.41 ? 136 PRO A N 1 ATOM 1096 C CA . PRO A 1 136 ? -9.203 72.739 -2.819 1.00 30.99 ? 136 PRO A CA 1 ATOM 1097 C C . PRO A 1 136 ? -10.564 72.751 -2.131 1.00 32.89 ? 136 PRO A C 1 ATOM 1098 O O . PRO A 1 136 ? -11.449 73.524 -2.497 1.00 32.50 ? 136 PRO A O 1 ATOM 1099 C CB . PRO A 1 136 ? -8.442 74.048 -2.618 1.00 30.95 ? 136 PRO A CB 1 ATOM 1100 C CG . PRO A 1 136 ? -7.524 74.078 -3.807 1.00 31.27 ? 136 PRO A CG 1 ATOM 1101 C CD . PRO A 1 136 ? -8.438 73.640 -4.934 1.00 29.20 ? 136 PRO A CD 1 ATOM 1102 N N . PRO A 1 137 ? -10.751 71.879 -1.129 1.00 35.30 ? 137 PRO A N 1 ATOM 1103 C CA . PRO A 1 137 ? -12.023 71.820 -0.404 1.00 37.55 ? 137 PRO A CA 1 ATOM 1104 C C . PRO A 1 137 ? -12.278 73.064 0.445 1.00 41.17 ? 137 PRO A C 1 ATOM 1105 O O . PRO A 1 137 ? -11.382 73.882 0.662 1.00 41.00 ? 137 PRO A O 1 ATOM 1106 C CB . PRO A 1 137 ? -11.890 70.551 0.435 1.00 36.97 ? 137 PRO A CB 1 ATOM 1107 C CG . PRO A 1 137 ? -10.411 70.432 0.648 1.00 36.88 ? 137 PRO A CG 1 ATOM 1108 C CD . PRO A 1 137 ? -9.845 70.801 -0.695 1.00 34.84 ? 137 PRO A CD 1 ATOM 1109 N N . GLU A 1 138 ? -13.514 73.186 0.912 1.00 45.47 ? 138 GLU A N 1 ATOM 1110 C CA . GLU A 1 138 ? -13.971 74.305 1.729 1.00 49.29 ? 138 GLU A CA 1 ATOM 1111 C C . GLU A 1 138 ? -12.919 75.206 2.382 1.00 48.48 ? 138 GLU A C 1 ATOM 1112 O O . GLU A 1 138 ? -12.561 76.253 1.832 1.00 50.70 ? 138 GLU A O 1 ATOM 1113 C CB . GLU A 1 138 ? -14.922 73.791 2.813 1.00 55.52 ? 138 GLU A CB 1 ATOM 1114 C CG . GLU A 1 138 ? -15.542 74.892 3.672 1.00 62.02 ? 138 GLU A CG 1 ATOM 1115 C CD . GLU A 1 138 ? -16.328 75.910 2.855 1.00 65.93 ? 138 GLU A CD 1 ATOM 1116 O OE1 . GLU A 1 138 ? -15.715 76.605 2.007 1.00 66.94 ? 138 GLU A OE1 1 ATOM 1117 O OE2 . GLU A 1 138 ? -17.560 76.012 3.063 1.00 67.35 ? 138 GLU A OE2 1 ATOM 1118 N N . GLY A 1 139 ? -12.433 74.813 3.554 1.00 44.16 ? 139 GLY A N 1 ATOM 1119 C CA . GLY A 1 139 ? -11.466 75.650 4.244 1.00 42.37 ? 139 GLY A CA 1 ATOM 1120 C C . GLY A 1 139 ? -9.996 75.310 4.089 1.00 41.58 ? 139 GLY A C 1 ATOM 1121 O O . GLY A 1 139 ? -9.251 75.341 5.072 1.00 42.28 ? 139 GLY A O 1 ATOM 1122 N N . VAL A 1 140 ? -9.573 75.001 2.865 1.00 38.32 ? 140 VAL A N 1 ATOM 1123 C CA . VAL A 1 140 ? -8.180 74.662 2.590 1.00 35.45 ? 140 VAL A CA 1 ATOM 1124 C C . VAL A 1 140 ? -7.574 75.696 1.644 1.00 35.31 ? 140 VAL A C 1 ATOM 1125 O O . VAL A 1 140 ? -8.187 76.057 0.636 1.00 35.09 ? 140 VAL A O 1 ATOM 1126 C CB . VAL A 1 140 ? -8.075 73.257 1.956 1.00 35.19 ? 140 VAL A CB 1 ATOM 1127 C CG1 . VAL A 1 140 ? -6.625 72.927 1.630 1.00 33.06 ? 140 VAL A CG1 1 ATOM 1128 C CG2 . VAL A 1 140 ? -8.656 72.225 2.907 1.00 31.90 ? 140 VAL A CG2 1 ATOM 1129 N N . LYS A 1 141 ? -6.377 76.177 1.967 1.00 34.51 ? 141 LYS A N 1 ATOM 1130 C CA . LYS A 1 141 ? -5.725 77.181 1.134 1.00 35.68 ? 141 LYS A CA 1 ATOM 1131 C C . LYS A 1 141 ? -5.348 76.649 -0.244 1.00 34.99 ? 141 LYS A C 1 ATOM 1132 O O . LYS A 1 141 ? -5.083 75.459 -0.410 1.00 34.67 ? 141 LYS A O 1 ATOM 1133 C CB . LYS A 1 141 ? -4.482 77.729 1.834 1.00 38.32 ? 141 LYS A CB 1 ATOM 1134 C CG . LYS A 1 141 ? -4.776 78.635 3.021 1.00 40.48 ? 141 LYS A CG 1 ATOM 1135 C CD . LYS A 1 141 ? -3.491 79.289 3.516 1.00 46.46 ? 141 LYS A CD 1 ATOM 1136 C CE . LYS A 1 141 ? -3.762 80.340 4.586 1.00 49.57 ? 141 LYS A CE 1 ATOM 1137 N NZ . LYS A 1 141 ? -4.419 79.752 5.786 1.00 51.97 ? 141 LYS A NZ 1 ATOM 1138 N N . ASP A 1 142 ? -5.315 77.544 -1.227 1.00 34.52 ? 142 ASP A N 1 ATOM 1139 C CA . ASP A 1 142 ? -4.989 77.174 -2.599 1.00 34.23 ? 142 ASP A CA 1 ATOM 1140 C C . ASP A 1 142 ? -3.617 76.548 -2.793 1.00 33.42 ? 142 ASP A C 1 ATOM 1141 O O . ASP A 1 142 ? -3.369 75.901 -3.813 1.00 32.27 ? 142 ASP A O 1 ATOM 1142 C CB . ASP A 1 142 ? -5.110 78.387 -3.525 1.00 36.16 ? 142 ASP A CB 1 ATOM 1143 C CG . ASP A 1 142 ? -6.542 78.856 -3.689 1.00 38.28 ? 142 ASP A CG 1 ATOM 1144 O OD1 . ASP A 1 142 ? -7.468 78.012 -3.644 1.00 38.86 ? 142 ASP A OD1 1 ATOM 1145 O OD2 . ASP A 1 142 ? -6.739 80.072 -3.882 1.00 40.97 ? 142 ASP A OD2 1 ATOM 1146 N N . ASP A 1 143 ? -2.720 76.739 -1.834 1.00 31.71 ? 143 ASP A N 1 ATOM 1147 C CA . ASP A 1 143 ? -1.388 76.163 -1.958 1.00 30.18 ? 143 ASP A CA 1 ATOM 1148 C C . ASP A 1 143 ? -1.099 75.110 -0.889 1.00 27.89 ? 143 ASP A C 1 ATOM 1149 O O . ASP A 1 143 ? 0.056 74.882 -0.525 1.00 28.57 ? 143 ASP A O 1 ATOM 1150 C CB . ASP A 1 143 ? -0.329 77.269 -1.921 1.00 31.10 ? 143 ASP A CB 1 ATOM 1151 C CG . ASP A 1 143 ? -0.320 78.032 -0.613 1.00 34.77 ? 143 ASP A CG 1 ATOM 1152 O OD1 . ASP A 1 143 ? 0.574 78.886 -0.446 1.00 40.24 ? 143 ASP A OD1 1 ATOM 1153 O OD2 . ASP A 1 143 ? -1.191 77.786 0.250 1.00 36.10 ? 143 ASP A OD2 1 ATOM 1154 N N . CYS A 1 144 ? -2.154 74.464 -0.400 1.00 24.47 ? 144 CYS A N 1 ATOM 1155 C CA . CYS A 1 144 ? -2.026 73.423 0.615 1.00 24.32 ? 144 CYS A CA 1 ATOM 1156 C C . CYS A 1 144 ? -2.902 72.223 0.249 1.00 24.19 ? 144 CYS A C 1 ATOM 1157 O O . CYS A 1 144 ? -3.542 71.622 1.108 1.00 23.42 ? 144 CYS A O 1 ATOM 1158 C CB . CYS A 1 144 ? -2.448 73.968 1.987 1.00 26.61 ? 144 CYS A CB 1 ATOM 1159 S SG . CYS A 1 144 ? -1.424 75.338 2.619 1.00 30.00 ? 144 CYS A SG 1 ATOM 1160 N N . PHE A 1 145 ? -2.913 71.863 -1.029 1.00 23.99 ? 145 PHE A N 1 ATOM 1161 C CA . PHE A 1 145 ? -3.748 70.759 -1.494 1.00 25.26 ? 145 PHE A CA 1 ATOM 1162 C C . PHE A 1 145 ? -3.076 70.098 -2.699 1.00 25.37 ? 145 PHE A C 1 ATOM 1163 O O . PHE A 1 145 ? -3.304 70.504 -3.840 1.00 25.40 ? 145 PHE A O 1 ATOM 1164 C CB . PHE A 1 145 ? -5.112 71.327 -1.884 1.00 24.49 ? 145 PHE A CB 1 ATOM 1165 C CG . PHE A 1 145 ? -6.102 70.300 -2.333 1.00 26.16 ? 145 PHE A CG 1 ATOM 1166 C CD1 . PHE A 1 145 ? -6.523 69.294 -1.472 1.00 24.90 ? 145 PHE A CD1 1 ATOM 1167 C CD2 . PHE A 1 145 ? -6.656 70.367 -3.609 1.00 26.36 ? 145 PHE A CD2 1 ATOM 1168 C CE1 . PHE A 1 145 ? -7.485 68.369 -1.872 1.00 23.91 ? 145 PHE A CE1 1 ATOM 1169 C CE2 . PHE A 1 145 ? -7.617 69.448 -4.015 1.00 26.30 ? 145 PHE A CE2 1 ATOM 1170 C CZ . PHE A 1 145 ? -8.032 68.447 -3.142 1.00 24.82 ? 145 PHE A CZ 1 ATOM 1171 N N . ARG A 1 146 ? -2.272 69.066 -2.456 1.00 24.24 ? 146 ARG A N 1 ATOM 1172 C CA . ARG A 1 146 ? -1.556 68.436 -3.561 1.00 23.98 ? 146 ARG A CA 1 ATOM 1173 C C . ARG A 1 146 ? -1.107 66.987 -3.382 1.00 23.40 ? 146 ARG A C 1 ATOM 1174 O O . ARG A 1 146 ? -1.314 66.361 -2.339 1.00 21.48 ? 146 ARG A O 1 ATOM 1175 C CB . ARG A 1 146 ? -0.318 69.274 -3.871 1.00 23.63 ? 146 ARG A CB 1 ATOM 1176 C CG . ARG A 1 146 ? 0.583 69.451 -2.645 1.00 23.14 ? 146 ARG A CG 1 ATOM 1177 C CD . ARG A 1 146 ? 1.851 70.219 -2.967 1.00 24.30 ? 146 ARG A CD 1 ATOM 1178 N NE . ARG A 1 146 ? 2.636 70.508 -1.771 1.00 27.07 ? 146 ARG A NE 1 ATOM 1179 C CZ . ARG A 1 146 ? 2.266 71.356 -0.814 1.00 29.72 ? 146 ARG A CZ 1 ATOM 1180 N NH1 . ARG A 1 146 ? 1.115 72.013 -0.908 1.00 29.35 ? 146 ARG A NH1 1 ATOM 1181 N NH2 . ARG A 1 146 ? 3.047 71.547 0.242 1.00 26.29 ? 146 ARG A NH2 1 ATOM 1182 N N . ASP A 1 147 ? -0.481 66.485 -4.443 1.00 23.11 ? 147 ASP A N 1 ATOM 1183 C CA . ASP A 1 147 ? 0.090 65.145 -4.517 1.00 23.15 ? 147 ASP A CA 1 ATOM 1184 C C . ASP A 1 147 ? -0.858 63.957 -4.389 1.00 23.33 ? 147 ASP A C 1 ATOM 1185 O O . ASP A 1 147 ? -0.787 63.200 -3.417 1.00 23.39 ? 147 ASP A O 1 ATOM 1186 C CB . ASP A 1 147 ? 1.212 65.008 -3.481 1.00 22.61 ? 147 ASP A CB 1 ATOM 1187 C CG . ASP A 1 147 ? 2.145 66.210 -3.466 1.00 23.70 ? 147 ASP A CG 1 ATOM 1188 O OD1 . ASP A 1 147 ? 2.256 66.906 -4.500 1.00 24.54 ? 147 ASP A OD1 1 ATOM 1189 O OD2 . ASP A 1 147 ? 2.781 66.453 -2.420 1.00 23.80 ? 147 ASP A OD2 1 ATOM 1190 N N . PRO A 1 148 ? -1.749 63.763 -5.377 1.00 22.87 ? 148 PRO A N 1 ATOM 1191 C CA . PRO A 1 148 ? -2.684 62.633 -5.315 1.00 22.12 ? 148 PRO A CA 1 ATOM 1192 C C . PRO A 1 148 ? -1.917 61.310 -5.388 1.00 21.63 ? 148 PRO A C 1 ATOM 1193 O O . PRO A 1 148 ? -0.893 61.207 -6.064 1.00 20.62 ? 148 PRO A O 1 ATOM 1194 C CB . PRO A 1 148 ? -3.591 62.865 -6.525 1.00 22.20 ? 148 PRO A CB 1 ATOM 1195 C CG . PRO A 1 148 ? -2.685 63.558 -7.498 1.00 23.33 ? 148 PRO A CG 1 ATOM 1196 C CD . PRO A 1 148 ? -1.928 64.534 -6.621 1.00 23.20 ? 148 PRO A CD 1 ATOM 1197 N N . SER A 1 149 ? -2.415 60.304 -4.683 1.00 20.79 ? 149 SER A N 1 ATOM 1198 C CA . SER A 1 149 ? -1.773 58.996 -4.642 1.00 20.32 ? 149 SER A CA 1 ATOM 1199 C C . SER A 1 149 ? -2.311 58.070 -5.719 1.00 21.51 ? 149 SER A C 1 ATOM 1200 O O . SER A 1 149 ? -3.179 58.446 -6.506 1.00 20.81 ? 149 SER A O 1 ATOM 1201 C CB . SER A 1 149 ? -2.042 58.334 -3.292 1.00 21.81 ? 149 SER A CB 1 ATOM 1202 O OG . SER A 1 149 ? -3.401 57.909 -3.210 1.00 18.01 ? 149 SER A OG 1 ATOM 1203 N N . THR A 1 150 ? -1.780 56.853 -5.748 1.00 21.30 ? 150 THR A N 1 ATOM 1204 C CA . THR A 1 150 ? -2.263 55.846 -6.674 1.00 21.38 ? 150 THR A CA 1 ATOM 1205 C C . THR A 1 150 ? -3.620 55.471 -6.084 1.00 22.07 ? 150 THR A C 1 ATOM 1206 O O . THR A 1 150 ? -3.793 55.503 -4.866 1.00 22.51 ? 150 THR A O 1 ATOM 1207 C CB . THR A 1 150 ? -1.344 54.616 -6.682 1.00 21.49 ? 150 THR A CB 1 ATOM 1208 O OG1 . THR A 1 150 ? -0.166 54.918 -7.437 1.00 22.30 ? 150 THR A OG1 1 ATOM 1209 C CG2 . THR A 1 150 ? -2.051 53.408 -7.295 1.00 19.76 ? 150 THR A CG2 1 ATOM 1210 N N . ALA A 1 151 ? -4.583 55.130 -6.931 1.00 21.44 ? 151 ALA A N 1 ATOM 1211 C CA . ALA A 1 151 ? -5.914 54.781 -6.447 1.00 20.56 ? 151 ALA A CA 1 ATOM 1212 C C . ALA A 1 151 ? -6.075 53.300 -6.148 1.00 20.74 ? 151 ALA A C 1 ATOM 1213 O O . ALA A 1 151 ? -5.305 52.468 -6.630 1.00 21.48 ? 151 ALA A O 1 ATOM 1214 C CB . ALA A 1 151 ? -6.957 55.202 -7.471 1.00 18.39 ? 151 ALA A CB 1 ATOM 1215 N N . TRP A 1 152 ? -7.072 52.975 -5.332 1.00 21.23 ? 152 TRP A N 1 ATOM 1216 C CA . TRP A 1 152 ? -7.371 51.582 -5.036 1.00 22.99 ? 152 TRP A CA 1 ATOM 1217 C C . TRP A 1 152 ? -8.872 51.370 -5.236 1.00 24.49 ? 152 TRP A C 1 ATOM 1218 O O . TRP A 1 152 ? -9.687 52.236 -4.906 1.00 24.19 ? 152 TRP A O 1 ATOM 1219 C CB . TRP A 1 152 ? -6.900 51.181 -3.625 1.00 21.30 ? 152 TRP A CB 1 ATOM 1220 C CG . TRP A 1 152 ? -7.456 51.961 -2.474 1.00 23.67 ? 152 TRP A CG 1 ATOM 1221 C CD1 . TRP A 1 152 ? -8.511 51.611 -1.675 1.00 22.89 ? 152 TRP A CD1 1 ATOM 1222 C CD2 . TRP A 1 152 ? -6.947 53.195 -1.949 1.00 24.46 ? 152 TRP A CD2 1 ATOM 1223 N NE1 . TRP A 1 152 ? -8.685 52.549 -0.681 1.00 24.27 ? 152 TRP A NE1 1 ATOM 1224 C CE2 . TRP A 1 152 ? -7.739 53.531 -0.826 1.00 25.00 ? 152 TRP A CE2 1 ATOM 1225 C CE3 . TRP A 1 152 ? -5.897 54.048 -2.318 1.00 24.06 ? 152 TRP A CE3 1 ATOM 1226 C CZ2 . TRP A 1 152 ? -7.514 54.685 -0.068 1.00 26.24 ? 152 TRP A CZ2 1 ATOM 1227 C CZ3 . TRP A 1 152 ? -5.673 55.196 -1.567 1.00 26.24 ? 152 TRP A CZ3 1 ATOM 1228 C CH2 . TRP A 1 152 ? -6.480 55.504 -0.452 1.00 27.96 ? 152 TRP A CH2 1 ATOM 1229 N N . LEU A 1 153 ? -9.224 50.231 -5.826 1.00 27.07 ? 153 LEU A N 1 ATOM 1230 C CA . LEU A 1 153 ? -10.615 49.901 -6.115 1.00 28.99 ? 153 LEU A CA 1 ATOM 1231 C C . LEU A 1 153 ? -11.201 49.018 -5.023 1.00 30.93 ? 153 LEU A C 1 ATOM 1232 O O . LEU A 1 153 ? -10.731 47.902 -4.797 1.00 32.35 ? 153 LEU A O 1 ATOM 1233 C CB . LEU A 1 153 ? -10.707 49.188 -7.470 1.00 27.48 ? 153 LEU A CB 1 ATOM 1234 C CG . LEU A 1 153 ? -12.093 48.864 -8.046 1.00 27.56 ? 153 LEU A CG 1 ATOM 1235 C CD1 . LEU A 1 153 ? -12.862 50.152 -8.314 1.00 25.22 ? 153 LEU A CD1 1 ATOM 1236 C CD2 . LEU A 1 153 ? -11.934 48.076 -9.341 1.00 25.33 ? 153 LEU A CD2 1 ATOM 1237 N N . GLY A 1 154 ? -12.227 49.525 -4.346 1.00 32.17 ? 154 GLY A N 1 ATOM 1238 C CA . GLY A 1 154 ? -12.854 48.765 -3.283 1.00 34.01 ? 154 GLY A CA 1 ATOM 1239 C C . GLY A 1 154 ? -13.741 47.659 -3.819 1.00 36.73 ? 154 GLY A C 1 ATOM 1240 O O . GLY A 1 154 ? -14.072 47.649 -5.005 1.00 36.63 ? 154 GLY A O 1 ATOM 1241 N N . PRO A 1 155 ? -14.149 46.708 -2.968 1.00 38.50 ? 155 PRO A N 1 ATOM 1242 C CA . PRO A 1 155 ? -15.010 45.611 -3.423 1.00 38.76 ? 155 PRO A CA 1 ATOM 1243 C C . PRO A 1 155 ? -16.344 46.117 -3.976 1.00 38.78 ? 155 PRO A C 1 ATOM 1244 O O . PRO A 1 155 ? -17.030 45.406 -4.712 1.00 38.73 ? 155 PRO A O 1 ATOM 1245 C CB . PRO A 1 155 ? -15.177 44.762 -2.164 1.00 39.42 ? 155 PRO A CB 1 ATOM 1246 C CG . PRO A 1 155 ? -15.104 45.787 -1.060 1.00 39.78 ? 155 PRO A CG 1 ATOM 1247 C CD . PRO A 1 155 ? -13.946 46.651 -1.508 1.00 39.55 ? 155 PRO A CD 1 ATOM 1248 N N . ASP A 1 156 ? -16.699 47.351 -3.629 1.00 37.15 ? 156 ASP A N 1 ATOM 1249 C CA . ASP A 1 156 ? -17.948 47.945 -4.092 1.00 36.10 ? 156 ASP A CA 1 ATOM 1250 C C . ASP A 1 156 ? -17.793 48.609 -5.460 1.00 35.22 ? 156 ASP A C 1 ATOM 1251 O O . ASP A 1 156 ? -18.702 49.286 -5.936 1.00 35.04 ? 156 ASP A O 1 ATOM 1252 C CB . ASP A 1 156 ? -18.447 48.972 -3.069 1.00 35.91 ? 156 ASP A CB 1 ATOM 1253 C CG . ASP A 1 156 ? -17.448 50.090 -2.830 1.00 37.93 ? 156 ASP A CG 1 ATOM 1254 O OD1 . ASP A 1 156 ? -16.281 49.944 -3.246 1.00 38.22 ? 156 ASP A OD1 1 ATOM 1255 O OD2 . ASP A 1 156 ? -17.826 51.112 -2.216 1.00 40.03 ? 156 ASP A OD2 1 ATOM 1256 N N . GLY A 1 157 ? -16.635 48.420 -6.085 1.00 34.44 ? 157 GLY A N 1 ATOM 1257 C CA . GLY A 1 157 ? -16.399 49.008 -7.394 1.00 32.28 ? 157 GLY A CA 1 ATOM 1258 C C . GLY A 1 157 ? -16.157 50.509 -7.397 1.00 32.29 ? 157 GLY A C 1 ATOM 1259 O O . GLY A 1 157 ? -16.271 51.154 -8.442 1.00 31.88 ? 157 GLY A O 1 ATOM 1260 N N . VAL A 1 158 ? -15.825 51.072 -6.238 1.00 29.49 ? 158 VAL A N 1 ATOM 1261 C CA . VAL A 1 158 ? -15.559 52.503 -6.130 1.00 28.26 ? 158 VAL A CA 1 ATOM 1262 C C . VAL A 1 158 ? -14.063 52.747 -5.916 1.00 28.09 ? 158 VAL A C 1 ATOM 1263 O O . VAL A 1 158 ? -13.426 52.061 -5.113 1.00 28.36 ? 158 VAL A O 1 ATOM 1264 C CB . VAL A 1 158 ? -16.340 53.130 -4.948 1.00 28.60 ? 158 VAL A CB 1 ATOM 1265 C CG1 . VAL A 1 158 ? -16.041 54.617 -4.850 1.00 26.43 ? 158 VAL A CG1 1 ATOM 1266 C CG2 . VAL A 1 158 ? -17.830 52.912 -5.135 1.00 26.74 ? 158 VAL A CG2 1 ATOM 1267 N N . TRP A 1 159 ? -13.505 53.715 -6.641 1.00 26.55 ? 159 TRP A N 1 ATOM 1268 C CA . TRP A 1 159 ? -12.086 54.041 -6.511 1.00 26.85 ? 159 TRP A CA 1 ATOM 1269 C C . TRP A 1 159 ? -11.845 55.003 -5.354 1.00 26.99 ? 159 TRP A C 1 ATOM 1270 O O . TRP A 1 159 ? -12.697 55.832 -5.033 1.00 28.22 ? 159 TRP A O 1 ATOM 1271 C CB . TRP A 1 159 ? -11.538 54.704 -7.785 1.00 25.16 ? 159 TRP A CB 1 ATOM 1272 C CG . TRP A 1 159 ? -11.381 53.808 -8.982 1.00 27.17 ? 159 TRP A CG 1 ATOM 1273 C CD1 . TRP A 1 159 ? -12.213 53.732 -10.065 1.00 26.56 ? 159 TRP A CD1 1 ATOM 1274 C CD2 . TRP A 1 159 ? -10.308 52.886 -9.235 1.00 26.54 ? 159 TRP A CD2 1 ATOM 1275 N NE1 . TRP A 1 159 ? -11.723 52.824 -10.977 1.00 26.59 ? 159 TRP A NE1 1 ATOM 1276 C CE2 . TRP A 1 159 ? -10.558 52.289 -10.495 1.00 25.65 ? 159 TRP A CE2 1 ATOM 1277 C CE3 . TRP A 1 159 ? -9.163 52.506 -8.519 1.00 25.11 ? 159 TRP A CE3 1 ATOM 1278 C CZ2 . TRP A 1 159 ? -9.703 51.332 -11.057 1.00 26.56 ? 159 TRP A CZ2 1 ATOM 1279 C CZ3 . TRP A 1 159 ? -8.309 51.551 -9.079 1.00 26.24 ? 159 TRP A CZ3 1 ATOM 1280 C CH2 . TRP A 1 159 ? -8.586 50.975 -10.336 1.00 26.05 ? 159 TRP A CH2 1 ATOM 1281 N N . ARG A 1 160 ? -10.674 54.888 -4.740 1.00 27.00 ? 160 ARG A N 1 ATOM 1282 C CA . ARG A 1 160 ? -10.279 55.774 -3.653 1.00 27.04 ? 160 ARG A CA 1 ATOM 1283 C C . ARG A 1 160 ? -8.884 56.315 -3.916 1.00 26.66 ? 160 ARG A C 1 ATOM 1284 O O . ARG A 1 160 ? -8.056 55.650 -4.540 1.00 26.31 ? 160 ARG A O 1 ATOM 1285 C CB . ARG A 1 160 ? -10.238 55.038 -2.313 1.00 28.15 ? 160 ARG A CB 1 ATOM 1286 C CG . ARG A 1 160 ? -11.541 54.956 -1.556 1.00 29.29 ? 160 ARG A CG 1 ATOM 1287 C CD . ARG A 1 160 ? -12.370 53.789 -2.012 1.00 32.33 ? 160 ARG A CD 1 ATOM 1288 N NE . ARG A 1 160 ? -13.332 53.402 -0.988 1.00 33.38 ? 160 ARG A NE 1 ATOM 1289 C CZ . ARG A 1 160 ? -14.242 52.447 -1.139 1.00 34.98 ? 160 ARG A CZ 1 ATOM 1290 N NH1 . ARG A 1 160 ? -14.322 51.774 -2.282 1.00 35.12 ? 160 ARG A NH1 1 ATOM 1291 N NH2 . ARG A 1 160 ? -15.071 52.164 -0.146 1.00 35.85 ? 160 ARG A NH2 1 ATOM 1292 N N . ILE A 1 161 ? -8.634 57.528 -3.435 1.00 26.41 ? 161 ILE A N 1 ATOM 1293 C CA . ILE A 1 161 ? -7.323 58.163 -3.541 1.00 24.99 ? 161 ILE A CA 1 ATOM 1294 C C . ILE A 1 161 ? -7.231 59.162 -2.409 1.00 25.39 ? 161 ILE A C 1 ATOM 1295 O O . ILE A 1 161 ? -8.247 59.582 -1.853 1.00 25.26 ? 161 ILE A O 1 ATOM 1296 C CB . ILE A 1 161 ? -7.122 58.985 -4.832 1.00 24.76 ? 161 ILE A CB 1 ATOM 1297 C CG1 . ILE A 1 161 ? -8.174 60.092 -4.903 1.00 24.04 ? 161 ILE A CG1 1 ATOM 1298 C CG2 . ILE A 1 161 ? -7.132 58.088 -6.043 1.00 23.96 ? 161 ILE A CG2 1 ATOM 1299 C CD1 . ILE A 1 161 ? -7.892 61.121 -5.968 1.00 27.65 ? 161 ILE A CD1 1 ATOM 1300 N N . VAL A 1 162 ? -6.012 59.541 -2.060 1.00 24.19 ? 162 VAL A N 1 ATOM 1301 C CA . VAL A 1 162 ? -5.840 60.548 -1.037 1.00 24.28 ? 162 VAL A CA 1 ATOM 1302 C C . VAL A 1 162 ? -5.071 61.679 -1.687 1.00 24.45 ? 162 VAL A C 1 ATOM 1303 O O . VAL A 1 162 ? -4.323 61.465 -2.645 1.00 24.76 ? 162 VAL A O 1 ATOM 1304 C CB . VAL A 1 162 ? -5.059 60.028 0.200 1.00 24.36 ? 162 VAL A CB 1 ATOM 1305 C CG1 . VAL A 1 162 ? -5.946 59.106 1.021 1.00 23.65 ? 162 VAL A CG1 1 ATOM 1306 C CG2 . VAL A 1 162 ? -3.793 59.311 -0.232 1.00 23.05 ? 162 VAL A CG2 1 ATOM 1307 N N . VAL A 1 163 ? -5.298 62.887 -1.195 1.00 24.61 ? 163 VAL A N 1 ATOM 1308 C CA . VAL A 1 163 ? -4.601 64.060 -1.689 1.00 25.35 ? 163 VAL A CA 1 ATOM 1309 C C . VAL A 1 163 ? -4.071 64.738 -0.434 1.00 26.49 ? 163 VAL A C 1 ATOM 1310 O O . VAL A 1 163 ? -4.800 64.901 0.546 1.00 26.87 ? 163 VAL A O 1 ATOM 1311 C CB . VAL A 1 163 ? -5.548 65.020 -2.447 1.00 25.13 ? 163 VAL A CB 1 ATOM 1312 C CG1 . VAL A 1 163 ? -4.781 66.252 -2.903 1.00 23.99 ? 163 VAL A CG1 1 ATOM 1313 C CG2 . VAL A 1 163 ? -6.157 64.311 -3.646 1.00 22.89 ? 163 VAL A CG2 1 ATOM 1314 N N . GLY A 1 164 ? -2.798 65.109 -0.457 1.00 26.51 ? 164 GLY A N 1 ATOM 1315 C CA . GLY A 1 164 ? -2.205 65.745 0.698 1.00 26.90 ? 164 GLY A CA 1 ATOM 1316 C C . GLY A 1 164 ? -2.615 67.190 0.854 1.00 28.41 ? 164 GLY A C 1 ATOM 1317 O O . GLY A 1 164 ? -3.091 67.825 -0.084 1.00 29.47 ? 164 GLY A O 1 ATOM 1318 N N . GLY A 1 165 ? -2.419 67.708 2.056 1.00 30.62 ? 165 GLY A N 1 ATOM 1319 C CA . GLY A 1 165 ? -2.756 69.088 2.343 1.00 31.68 ? 165 GLY A CA 1 ATOM 1320 C C . GLY A 1 165 ? -2.883 69.253 3.838 1.00 31.82 ? 165 GLY A C 1 ATOM 1321 O O . GLY A 1 165 ? -2.489 68.369 4.600 1.00 32.89 ? 165 GLY A O 1 ATOM 1322 N N . ASP A 1 166 ? -3.414 70.386 4.271 1.00 31.84 ? 166 ASP A N 1 ATOM 1323 C CA . ASP A 1 166 ? -3.610 70.607 5.693 1.00 32.99 ? 166 ASP A CA 1 ATOM 1324 C C . ASP A 1 166 ? -4.778 71.552 5.883 1.00 33.08 ? 166 ASP A C 1 ATOM 1325 O O . ASP A 1 166 ? -5.130 72.314 4.983 1.00 33.03 ? 166 ASP A O 1 ATOM 1326 C CB . ASP A 1 166 ? -2.342 71.186 6.342 1.00 31.54 ? 166 ASP A CB 1 ATOM 1327 C CG . ASP A 1 166 ? -2.135 72.657 6.028 1.00 31.81 ? 166 ASP A CG 1 ATOM 1328 O OD1 . ASP A 1 166 ? -2.822 73.505 6.640 1.00 30.85 ? 166 ASP A OD1 1 ATOM 1329 O OD2 . ASP A 1 166 ? -1.286 72.970 5.168 1.00 31.25 ? 166 ASP A OD2 1 ATOM 1330 N N . ARG A 1 167 ? -5.396 71.471 7.050 1.00 34.09 ? 167 ARG A N 1 ATOM 1331 C CA . ARG A 1 167 ? -6.505 72.342 7.383 1.00 35.46 ? 167 ARG A CA 1 ATOM 1332 C C . ARG A 1 167 ? -6.071 73.018 8.676 1.00 36.14 ? 167 ARG A C 1 ATOM 1333 O O . ARG A 1 167 ? -6.086 72.400 9.742 1.00 36.39 ? 167 ARG A O 1 ATOM 1334 C CB . ARG A 1 167 ? -7.777 71.525 7.599 1.00 36.37 ? 167 ARG A CB 1 ATOM 1335 C CG . ARG A 1 167 ? -9.023 72.367 7.805 1.00 38.03 ? 167 ARG A CG 1 ATOM 1336 C CD . ARG A 1 167 ? -10.221 71.490 8.144 1.00 38.15 ? 167 ARG A CD 1 ATOM 1337 N NE . ARG A 1 167 ? -10.672 70.682 7.012 1.00 38.92 ? 167 ARG A NE 1 ATOM 1338 C CZ . ARG A 1 167 ? -11.312 71.167 5.951 1.00 38.66 ? 167 ARG A CZ 1 ATOM 1339 N NH1 . ARG A 1 167 ? -11.582 72.466 5.864 1.00 36.18 ? 167 ARG A NH1 1 ATOM 1340 N NH2 . ARG A 1 167 ? -11.694 70.349 4.978 1.00 37.44 ? 167 ARG A NH2 1 ATOM 1341 N N . ASP A 1 168 ? -5.649 74.275 8.566 1.00 35.92 ? 168 ASP A N 1 ATOM 1342 C CA . ASP A 1 168 ? -5.185 75.038 9.718 1.00 37.22 ? 168 ASP A CA 1 ATOM 1343 C C . ASP A 1 168 ? -3.948 74.383 10.327 1.00 37.16 ? 168 ASP A C 1 ATOM 1344 O O . ASP A 1 168 ? -3.901 74.104 11.527 1.00 36.80 ? 168 ASP A O 1 ATOM 1345 C CB . ASP A 1 168 ? -6.294 75.149 10.768 1.00 38.39 ? 168 ASP A CB 1 ATOM 1346 C CG . ASP A 1 168 ? -7.537 75.832 10.227 1.00 40.85 ? 168 ASP A CG 1 ATOM 1347 O OD1 . ASP A 1 168 ? -7.407 76.947 9.669 1.00 40.50 ? 168 ASP A OD1 1 ATOM 1348 O OD2 . ASP A 1 168 ? -8.639 75.254 10.358 1.00 41.27 ? 168 ASP A OD2 1 ATOM 1349 N N . ASN A 1 169 ? -2.957 74.136 9.472 1.00 35.76 ? 169 ASN A N 1 ATOM 1350 C CA . ASN A 1 169 ? -1.688 73.527 9.855 1.00 34.44 ? 169 ASN A CA 1 ATOM 1351 C C . ASN A 1 169 ? -1.799 72.078 10.340 1.00 33.39 ? 169 ASN A C 1 ATOM 1352 O O . ASN A 1 169 ? -0.832 71.514 10.854 1.00 32.28 ? 169 ASN A O 1 ATOM 1353 C CB . ASN A 1 169 ? -0.992 74.385 10.917 1.00 34.23 ? 169 ASN A CB 1 ATOM 1354 C CG . ASN A 1 169 ? 0.486 74.061 11.051 1.00 35.40 ? 169 ASN A CG 1 ATOM 1355 O OD1 . ASN A 1 169 ? 1.236 74.125 10.076 1.00 33.74 ? 169 ASN A OD1 1 ATOM 1356 N ND2 . ASN A 1 169 ? 0.913 73.711 12.262 1.00 38.23 ? 169 ASN A ND2 1 ATOM 1357 N N . ASN A 1 170 ? -2.971 71.477 10.168 1.00 32.27 ? 170 ASN A N 1 ATOM 1358 C CA . ASN A 1 170 ? -3.180 70.088 10.571 1.00 32.38 ? 170 ASN A CA 1 ATOM 1359 C C . ASN A 1 170 ? -3.084 69.154 9.359 1.00 32.89 ? 170 ASN A C 1 ATOM 1360 O O . ASN A 1 170 ? -3.951 69.163 8.485 1.00 32.68 ? 170 ASN A O 1 ATOM 1361 C CB . ASN A 1 170 ? -4.549 69.935 11.233 1.00 32.95 ? 170 ASN A CB 1 ATOM 1362 C CG . ASN A 1 170 ? -4.630 70.638 12.577 1.00 35.67 ? 170 ASN A CG 1 ATOM 1363 O OD1 . ASN A 1 170 ? -5.717 70.933 13.067 1.00 36.84 ? 170 ASN A OD1 1 ATOM 1364 N ND2 . ASN A 1 170 ? -3.478 70.898 13.185 1.00 34.54 ? 170 ASN A ND2 1 ATOM 1365 N N . GLY A 1 171 ? -2.018 68.359 9.313 1.00 32.62 ? 171 GLY A N 1 ATOM 1366 C CA . GLY A 1 171 ? -1.817 67.429 8.215 1.00 31.08 ? 171 GLY A CA 1 ATOM 1367 C C . GLY A 1 171 ? -3.070 66.655 7.854 1.00 31.22 ? 171 GLY A C 1 ATOM 1368 O O . GLY A 1 171 ? -3.795 66.188 8.733 1.00 30.70 ? 171 GLY A O 1 ATOM 1369 N N . MET A 1 172 ? -3.311 66.504 6.555 1.00 29.92 ? 172 MET A N 1 ATOM 1370 C CA . MET A 1 172 ? -4.495 65.812 6.061 1.00 29.44 ? 172 MET A CA 1 ATOM 1371 C C . MET A 1 172 ? -4.234 64.880 4.876 1.00 28.44 ? 172 MET A C 1 ATOM 1372 O O . MET A 1 172 ? -3.432 65.182 3.994 1.00 26.44 ? 172 MET A O 1 ATOM 1373 C CB . MET A 1 172 ? -5.538 66.837 5.596 1.00 30.57 ? 172 MET A CB 1 ATOM 1374 C CG . MET A 1 172 ? -6.147 67.717 6.661 1.00 32.09 ? 172 MET A CG 1 ATOM 1375 S SD . MET A 1 172 ? -7.374 66.825 7.605 1.00 35.67 ? 172 MET A SD 1 ATOM 1376 C CE . MET A 1 172 ? -6.930 67.312 9.277 1.00 35.35 ? 172 MET A CE 1 ATOM 1377 N N . ALA A 1 173 ? -4.931 63.751 4.865 1.00 27.31 ? 173 ALA A N 1 ATOM 1378 C CA . ALA A 1 173 ? -4.868 62.814 3.749 1.00 26.40 ? 173 ALA A CA 1 ATOM 1379 C C . ALA A 1 173 ? -6.319 62.817 3.273 1.00 26.09 ? 173 ALA A C 1 ATOM 1380 O O . ALA A 1 173 ? -7.100 61.936 3.628 1.00 26.84 ? 173 ALA A O 1 ATOM 1381 C CB . ALA A 1 173 ? -4.468 61.426 4.213 1.00 25.76 ? 173 ALA A CB 1 ATOM 1382 N N . PHE A 1 174 ? -6.683 63.841 2.508 1.00 26.18 ? 174 PHE A N 1 ATOM 1383 C CA . PHE A 1 174 ? -8.044 63.979 1.998 1.00 26.97 ? 174 PHE A CA 1 ATOM 1384 C C . PHE A 1 174 ? -8.416 62.792 1.125 1.00 27.97 ? 174 PHE A C 1 ATOM 1385 O O . PHE A 1 174 ? -7.703 62.450 0.184 1.00 29.38 ? 174 PHE A O 1 ATOM 1386 C CB . PHE A 1 174 ? -8.180 65.283 1.207 1.00 27.40 ? 174 PHE A CB 1 ATOM 1387 C CG . PHE A 1 174 ? -7.996 66.521 2.045 1.00 27.94 ? 174 PHE A CG 1 ATOM 1388 C CD1 . PHE A 1 174 ? -8.874 66.809 3.088 1.00 27.78 ? 174 PHE A CD1 1 ATOM 1389 C CD2 . PHE A 1 174 ? -6.946 67.400 1.791 1.00 29.64 ? 174 PHE A CD2 1 ATOM 1390 C CE1 . PHE A 1 174 ? -8.710 67.956 3.865 1.00 27.80 ? 174 PHE A CE1 1 ATOM 1391 C CE2 . PHE A 1 174 ? -6.774 68.553 2.565 1.00 29.96 ? 174 PHE A CE2 1 ATOM 1392 C CZ . PHE A 1 174 ? -7.659 68.830 3.603 1.00 28.59 ? 174 PHE A CZ 1 ATOM 1393 N N . LEU A 1 175 ? -9.541 62.167 1.448 1.00 28.48 ? 175 LEU A N 1 ATOM 1394 C CA . LEU A 1 175 ? -10.015 60.998 0.728 1.00 28.42 ? 175 LEU A CA 1 ATOM 1395 C C . LEU A 1 175 ? -11.084 61.327 -0.310 1.00 28.84 ? 175 LEU A C 1 ATOM 1396 O O . LEU A 1 175 ? -12.052 62.032 -0.017 1.00 28.59 ? 175 LEU A O 1 ATOM 1397 C CB . LEU A 1 175 ? -10.570 59.986 1.730 1.00 29.56 ? 175 LEU A CB 1 ATOM 1398 C CG . LEU A 1 175 ? -11.106 58.658 1.199 1.00 31.31 ? 175 LEU A CG 1 ATOM 1399 C CD1 . LEU A 1 175 ? -9.986 57.881 0.533 1.00 31.38 ? 175 LEU A CD1 1 ATOM 1400 C CD2 . LEU A 1 175 ? -11.686 57.856 2.353 1.00 33.29 ? 175 LEU A CD2 1 ATOM 1401 N N . TYR A 1 176 ? -10.902 60.814 -1.524 1.00 28.24 ? 176 TYR A N 1 ATOM 1402 C CA . TYR A 1 176 ? -11.863 61.029 -2.599 1.00 28.70 ? 176 TYR A CA 1 ATOM 1403 C C . TYR A 1 176 ? -12.305 59.707 -3.203 1.00 29.70 ? 176 TYR A C 1 ATOM 1404 O O . TYR A 1 176 ? -11.540 58.739 -3.241 1.00 29.98 ? 176 TYR A O 1 ATOM 1405 C CB . TYR A 1 176 ? -11.275 61.921 -3.692 1.00 28.44 ? 176 TYR A CB 1 ATOM 1406 C CG . TYR A 1 176 ? -11.102 63.352 -3.256 1.00 28.86 ? 176 TYR A CG 1 ATOM 1407 C CD1 . TYR A 1 176 ? -10.024 63.734 -2.455 1.00 29.36 ? 176 TYR A CD1 1 ATOM 1408 C CD2 . TYR A 1 176 ? -12.044 64.319 -3.601 1.00 28.68 ? 176 TYR A CD2 1 ATOM 1409 C CE1 . TYR A 1 176 ? -9.891 65.047 -2.006 1.00 29.87 ? 176 TYR A CE1 1 ATOM 1410 C CE2 . TYR A 1 176 ? -11.922 65.632 -3.158 1.00 30.35 ? 176 TYR A CE2 1 ATOM 1411 C CZ . TYR A 1 176 ? -10.846 65.989 -2.361 1.00 30.41 ? 176 TYR A CZ 1 ATOM 1412 O OH . TYR A 1 176 ? -10.735 67.284 -1.917 1.00 31.86 ? 176 TYR A OH 1 ATOM 1413 N N . GLN A 1 177 ? -13.545 59.674 -3.673 1.00 30.65 ? 177 GLN A N 1 ATOM 1414 C CA . GLN A 1 177 ? -14.101 58.470 -4.269 1.00 32.41 ? 177 GLN A CA 1 ATOM 1415 C C . GLN A 1 177 ? -14.640 58.748 -5.665 1.00 30.99 ? 177 GLN A C 1 ATOM 1416 O O . GLN A 1 177 ? -15.032 59.873 -5.979 1.00 29.74 ? 177 GLN A O 1 ATOM 1417 C CB . GLN A 1 177 ? -15.202 57.918 -3.366 1.00 35.44 ? 177 GLN A CB 1 ATOM 1418 C CG . GLN A 1 177 ? -14.682 57.500 -1.995 1.00 45.19 ? 177 GLN A CG 1 ATOM 1419 C CD . GLN A 1 177 ? -15.785 57.337 -0.965 1.00 50.15 ? 177 GLN A CD 1 ATOM 1420 O OE1 . GLN A 1 177 ? -16.534 58.279 -0.691 1.00 55.10 ? 177 GLN A OE1 1 ATOM 1421 N NE2 . GLN A 1 177 ? -15.890 56.144 -0.384 1.00 51.15 ? 177 GLN A NE2 1 ATOM 1422 N N . SER A 1 178 ? -14.652 57.714 -6.501 1.00 29.59 ? 178 SER A N 1 ATOM 1423 C CA . SER A 1 178 ? -15.129 57.834 -7.876 1.00 28.52 ? 178 SER A CA 1 ATOM 1424 C C . SER A 1 178 ? -15.320 56.461 -8.519 1.00 29.89 ? 178 SER A C 1 ATOM 1425 O O . SER A 1 178 ? -14.597 55.512 -8.204 1.00 29.31 ? 178 SER A O 1 ATOM 1426 C CB . SER A 1 178 ? -14.125 58.637 -8.699 1.00 27.00 ? 178 SER A CB 1 ATOM 1427 O OG . SER A 1 178 ? -14.447 58.618 -10.076 1.00 27.53 ? 178 SER A OG 1 ATOM 1428 N N . THR A 1 179 ? -16.297 56.356 -9.415 1.00 29.32 ? 179 THR A N 1 ATOM 1429 C CA . THR A 1 179 ? -16.542 55.097 -10.109 1.00 29.13 ? 179 THR A CA 1 ATOM 1430 C C . THR A 1 179 ? -15.941 55.140 -11.513 1.00 28.54 ? 179 THR A C 1 ATOM 1431 O O . THR A 1 179 ? -15.482 54.119 -12.021 1.00 30.12 ? 179 THR A O 1 ATOM 1432 C CB . THR A 1 179 ? -18.062 54.778 -10.228 1.00 28.89 ? 179 THR A CB 1 ATOM 1433 O OG1 . THR A 1 179 ? -18.755 55.927 -10.727 1.00 31.78 ? 179 THR A OG1 1 ATOM 1434 C CG2 . THR A 1 179 ? -18.644 54.388 -8.879 1.00 27.91 ? 179 THR A CG2 1 ATOM 1435 N N . ASP A 1 180 ? -15.918 56.320 -12.130 1.00 28.04 ? 180 ASP A N 1 ATOM 1436 C CA . ASP A 1 180 ? -15.387 56.449 -13.490 1.00 28.79 ? 180 ASP A CA 1 ATOM 1437 C C . ASP A 1 180 ? -14.009 57.106 -13.581 1.00 28.16 ? 180 ASP A C 1 ATOM 1438 O O . ASP A 1 180 ? -13.504 57.352 -14.677 1.00 26.96 ? 180 ASP A O 1 ATOM 1439 C CB . ASP A 1 180 ? -16.371 57.228 -14.367 1.00 28.44 ? 180 ASP A CB 1 ATOM 1440 C CG . ASP A 1 180 ? -16.587 58.651 -13.881 1.00 30.80 ? 180 ASP A CG 1 ATOM 1441 O OD1 . ASP A 1 180 ? -15.843 59.102 -12.982 1.00 31.96 ? 180 ASP A OD1 1 ATOM 1442 O OD2 . ASP A 1 180 ? -17.501 59.322 -14.403 1.00 30.86 ? 180 ASP A OD2 1 ATOM 1443 N N . PHE A 1 181 ? -13.417 57.404 -12.429 1.00 27.09 ? 181 PHE A N 1 ATOM 1444 C CA . PHE A 1 181 ? -12.091 58.015 -12.364 1.00 25.88 ? 181 PHE A CA 1 ATOM 1445 C C . PHE A 1 181 ? -12.034 59.442 -12.914 1.00 26.05 ? 181 PHE A C 1 ATOM 1446 O O . PHE A 1 181 ? -10.952 60.029 -13.014 1.00 24.72 ? 181 PHE A O 1 ATOM 1447 C CB . PHE A 1 181 ? -11.071 57.147 -13.112 1.00 24.56 ? 181 PHE A CB 1 ATOM 1448 C CG . PHE A 1 181 ? -9.762 56.999 -12.391 1.00 24.14 ? 181 PHE A CG 1 ATOM 1449 C CD1 . PHE A 1 181 ? -9.645 56.129 -11.306 1.00 23.98 ? 181 PHE A CD1 1 ATOM 1450 C CD2 . PHE A 1 181 ? -8.656 57.759 -12.764 1.00 22.28 ? 181 PHE A CD2 1 ATOM 1451 C CE1 . PHE A 1 181 ? -8.445 56.020 -10.599 1.00 23.23 ? 181 PHE A CE1 1 ATOM 1452 C CE2 . PHE A 1 181 ? -7.453 57.661 -12.065 1.00 21.56 ? 181 PHE A CE2 1 ATOM 1453 C CZ . PHE A 1 181 ? -7.347 56.789 -10.978 1.00 23.49 ? 181 PHE A CZ 1 ATOM 1454 N N . VAL A 1 182 ? -13.192 59.997 -13.269 1.00 26.18 ? 182 VAL A N 1 ATOM 1455 C CA . VAL A 1 182 ? -13.257 61.358 -13.805 1.00 25.63 ? 182 VAL A CA 1 ATOM 1456 C C . VAL A 1 182 ? -14.003 62.293 -12.851 1.00 27.64 ? 182 VAL A C 1 ATOM 1457 O O . VAL A 1 182 ? -13.571 63.422 -12.615 1.00 28.43 ? 182 VAL A O 1 ATOM 1458 C CB . VAL A 1 182 ? -13.940 61.378 -15.192 1.00 25.06 ? 182 VAL A CB 1 ATOM 1459 C CG1 . VAL A 1 182 ? -14.152 62.813 -15.660 1.00 21.44 ? 182 VAL A CG1 1 ATOM 1460 C CG2 . VAL A 1 182 ? -13.079 60.626 -16.193 1.00 21.83 ? 182 VAL A CG2 1 ATOM 1461 N N . ASN A 1 183 ? -15.124 61.822 -12.314 1.00 28.55 ? 183 ASN A N 1 ATOM 1462 C CA . ASN A 1 183 ? -15.912 62.600 -11.366 1.00 30.19 ? 183 ASN A CA 1 ATOM 1463 C C . ASN A 1 183 ? -15.573 62.091 -9.973 1.00 30.47 ? 183 ASN A C 1 ATOM 1464 O O . ASN A 1 183 ? -15.896 60.953 -9.624 1.00 28.17 ? 183 ASN A O 1 ATOM 1465 C CB . ASN A 1 183 ? -17.406 62.415 -11.631 1.00 33.75 ? 183 ASN A CB 1 ATOM 1466 C CG . ASN A 1 183 ? -17.803 62.848 -13.025 1.00 39.42 ? 183 ASN A CG 1 ATOM 1467 O OD1 . ASN A 1 183 ? -17.789 64.039 -13.349 1.00 43.17 ? 183 ASN A OD1 1 ATOM 1468 N ND2 . ASN A 1 183 ? -18.148 61.880 -13.867 1.00 42.45 ? 183 ASN A ND2 1 ATOM 1469 N N . TRP A 1 184 ? -14.911 62.935 -9.187 1.00 29.93 ? 184 TRP A N 1 ATOM 1470 C CA . TRP A 1 184 ? -14.511 62.572 -7.832 1.00 30.06 ? 184 TRP A CA 1 ATOM 1471 C C . TRP A 1 184 ? -15.275 63.384 -6.790 1.00 31.37 ? 184 TRP A C 1 ATOM 1472 O O . TRP A 1 184 ? -15.589 64.554 -7.017 1.00 31.68 ? 184 TRP A O 1 ATOM 1473 C CB . TRP A 1 184 ? -13.010 62.805 -7.648 1.00 28.69 ? 184 TRP A CB 1 ATOM 1474 C CG . TRP A 1 184 ? -12.150 61.983 -8.545 1.00 26.52 ? 184 TRP A CG 1 ATOM 1475 C CD1 . TRP A 1 184 ? -11.809 62.259 -9.839 1.00 26.83 ? 184 TRP A CD1 1 ATOM 1476 C CD2 . TRP A 1 184 ? -11.528 60.735 -8.222 1.00 25.54 ? 184 TRP A CD2 1 ATOM 1477 N NE1 . TRP A 1 184 ? -11.010 61.257 -10.343 1.00 25.24 ? 184 TRP A NE1 1 ATOM 1478 C CE2 . TRP A 1 184 ? -10.822 60.310 -9.371 1.00 25.20 ? 184 TRP A CE2 1 ATOM 1479 C CE3 . TRP A 1 184 ? -11.500 59.932 -7.073 1.00 24.29 ? 184 TRP A CE3 1 ATOM 1480 C CZ2 . TRP A 1 184 ? -10.094 59.118 -9.403 1.00 25.04 ? 184 TRP A CZ2 1 ATOM 1481 C CZ3 . TRP A 1 184 ? -10.777 58.748 -7.104 1.00 23.90 ? 184 TRP A CZ3 1 ATOM 1482 C CH2 . TRP A 1 184 ? -10.083 58.353 -8.263 1.00 25.91 ? 184 TRP A CH2 1 ATOM 1483 N N . LYS A 1 185 ? -15.565 62.762 -5.651 1.00 32.69 ? 185 LYS A N 1 ATOM 1484 C CA . LYS A 1 185 ? -16.284 63.433 -4.574 1.00 35.92 ? 185 LYS A CA 1 ATOM 1485 C C . LYS A 1 185 ? -15.531 63.265 -3.266 1.00 35.37 ? 185 LYS A C 1 ATOM 1486 O O . LYS A 1 185 ? -15.145 62.152 -2.906 1.00 34.02 ? 185 LYS A O 1 ATOM 1487 C CB . LYS A 1 185 ? -17.694 62.857 -4.428 1.00 39.56 ? 185 LYS A CB 1 ATOM 1488 C CG . LYS A 1 185 ? -18.450 62.804 -5.742 1.00 47.83 ? 185 LYS A CG 1 ATOM 1489 C CD . LYS A 1 185 ? -19.948 62.611 -5.553 1.00 51.72 ? 185 LYS A CD 1 ATOM 1490 C CE . LYS A 1 185 ? -20.641 62.483 -6.908 1.00 55.00 ? 185 LYS A CE 1 ATOM 1491 N NZ . LYS A 1 185 ? -20.212 63.559 -7.860 1.00 57.01 ? 185 LYS A NZ 1 ATOM 1492 N N . ARG A 1 186 ? -15.317 64.371 -2.557 1.00 35.71 ? 186 ARG A N 1 ATOM 1493 C CA . ARG A 1 186 ? -14.604 64.314 -1.290 1.00 37.65 ? 186 ARG A CA 1 ATOM 1494 C C . ARG A 1 186 ? -15.419 63.556 -0.257 1.00 36.84 ? 186 ARG A C 1 ATOM 1495 O O . ARG A 1 186 ? -16.624 63.757 -0.140 1.00 37.41 ? 186 ARG A O 1 ATOM 1496 C CB . ARG A 1 186 ? -14.307 65.723 -0.757 1.00 40.21 ? 186 ARG A CB 1 ATOM 1497 C CG . ARG A 1 186 ? -13.502 65.712 0.548 1.00 45.64 ? 186 ARG A CG 1 ATOM 1498 C CD . ARG A 1 186 ? -13.031 67.100 1.003 1.00 50.36 ? 186 ARG A CD 1 ATOM 1499 N NE . ARG A 1 186 ? -14.032 67.857 1.762 1.00 54.45 ? 186 ARG A NE 1 ATOM 1500 C CZ . ARG A 1 186 ? -14.936 68.677 1.225 1.00 58.36 ? 186 ARG A CZ 1 ATOM 1501 N NH1 . ARG A 1 186 ? -14.985 68.859 -0.091 1.00 59.56 ? 186 ARG A NH1 1 ATOM 1502 N NH2 . ARG A 1 186 ? -15.787 69.332 2.009 1.00 57.75 ? 186 ARG A NH2 1 ATOM 1503 N N . TYR A 1 187 ? -14.762 62.671 0.480 1.00 37.49 ? 187 TYR A N 1 ATOM 1504 C CA . TYR A 1 187 ? -15.438 61.924 1.529 1.00 37.79 ? 187 TYR A CA 1 ATOM 1505 C C . TYR A 1 187 ? -15.565 62.899 2.702 1.00 39.10 ? 187 TYR A C 1 ATOM 1506 O O . TYR A 1 187 ? -14.779 63.843 2.817 1.00 38.04 ? 187 TYR A O 1 ATOM 1507 C CB . TYR A 1 187 ? -14.601 60.711 1.937 1.00 37.09 ? 187 TYR A CB 1 ATOM 1508 C CG . TYR A 1 187 ? -15.323 59.757 2.855 1.00 36.11 ? 187 TYR A CG 1 ATOM 1509 C CD1 . TYR A 1 187 ? -16.391 58.994 2.393 1.00 35.52 ? 187 TYR A CD1 1 ATOM 1510 C CD2 . TYR A 1 187 ? -14.952 59.632 4.195 1.00 36.84 ? 187 TYR A CD2 1 ATOM 1511 C CE1 . TYR A 1 187 ? -17.079 58.127 3.242 1.00 36.67 ? 187 TYR A CE1 1 ATOM 1512 C CE2 . TYR A 1 187 ? -15.631 58.769 5.057 1.00 37.16 ? 187 TYR A CE2 1 ATOM 1513 C CZ . TYR A 1 187 ? -16.695 58.018 4.573 1.00 38.47 ? 187 TYR A CZ 1 ATOM 1514 O OH . TYR A 1 187 ? -17.370 57.155 5.412 1.00 37.76 ? 187 TYR A OH 1 ATOM 1515 N N . ASP A 1 188 ? -16.549 62.684 3.566 1.00 41.59 ? 188 ASP A N 1 ATOM 1516 C CA . ASP A 1 188 ? -16.759 63.570 4.709 1.00 44.74 ? 188 ASP A CA 1 ATOM 1517 C C . ASP A 1 188 ? -15.501 63.775 5.562 1.00 43.32 ? 188 ASP A C 1 ATOM 1518 O O . ASP A 1 188 ? -15.094 64.907 5.819 1.00 42.26 ? 188 ASP A O 1 ATOM 1519 C CB . ASP A 1 188 ? -17.879 63.027 5.599 1.00 50.36 ? 188 ASP A CB 1 ATOM 1520 C CG . ASP A 1 188 ? -18.169 63.936 6.783 1.00 56.92 ? 188 ASP A CG 1 ATOM 1521 O OD1 . ASP A 1 188 ? -18.742 63.449 7.785 1.00 59.47 ? 188 ASP A OD1 1 ATOM 1522 O OD2 . ASP A 1 188 ? -17.828 65.141 6.706 1.00 59.03 ? 188 ASP A OD2 1 ATOM 1523 N N . GLN A 1 189 ? -14.898 62.675 6.004 1.00 41.75 ? 189 GLN A N 1 ATOM 1524 C CA . GLN A 1 189 ? -13.697 62.728 6.831 1.00 40.59 ? 189 GLN A CA 1 ATOM 1525 C C . GLN A 1 189 ? -12.452 62.325 6.046 1.00 38.73 ? 189 GLN A C 1 ATOM 1526 O O . GLN A 1 189 ? -12.541 61.581 5.073 1.00 39.91 ? 189 GLN A O 1 ATOM 1527 C CB . GLN A 1 189 ? -13.851 61.787 8.029 1.00 42.01 ? 189 GLN A CB 1 ATOM 1528 C CG . GLN A 1 189 ? -14.962 62.169 8.991 1.00 44.76 ? 189 GLN A CG 1 ATOM 1529 C CD . GLN A 1 189 ? -14.775 63.565 9.556 1.00 47.55 ? 189 GLN A CD 1 ATOM 1530 O OE1 . GLN A 1 189 ? -13.708 63.901 10.073 1.00 47.64 ? 189 GLN A OE1 1 ATOM 1531 N NE2 . GLN A 1 189 ? -15.815 64.387 9.462 1.00 50.27 ? 189 GLN A NE2 1 ATOM 1532 N N . PRO A 1 190 ? -11.273 62.823 6.453 1.00 36.36 ? 190 PRO A N 1 ATOM 1533 C CA . PRO A 1 190 ? -10.045 62.459 5.742 1.00 33.53 ? 190 PRO A CA 1 ATOM 1534 C C . PRO A 1 190 ? -9.683 61.023 6.113 1.00 31.79 ? 190 PRO A C 1 ATOM 1535 O O . PRO A 1 190 ? -10.142 60.521 7.136 1.00 31.27 ? 190 PRO A O 1 ATOM 1536 C CB . PRO A 1 190 ? -9.033 63.467 6.274 1.00 33.14 ? 190 PRO A CB 1 ATOM 1537 C CG . PRO A 1 190 ? -9.485 63.663 7.684 1.00 33.14 ? 190 PRO A CG 1 ATOM 1538 C CD . PRO A 1 190 ? -10.989 63.797 7.523 1.00 34.58 ? 190 PRO A CD 1 ATOM 1539 N N . LEU A 1 191 ? -8.882 60.356 5.286 1.00 30.92 ? 191 LEU A N 1 ATOM 1540 C CA . LEU A 1 191 ? -8.490 58.984 5.590 1.00 29.51 ? 191 LEU A CA 1 ATOM 1541 C C . LEU A 1 191 ? -7.736 58.979 6.915 1.00 29.38 ? 191 LEU A C 1 ATOM 1542 O O . LEU A 1 191 ? -7.948 58.114 7.767 1.00 29.97 ? 191 LEU A O 1 ATOM 1543 C CB . LEU A 1 191 ? -7.597 58.412 4.486 1.00 28.60 ? 191 LEU A CB 1 ATOM 1544 C CG . LEU A 1 191 ? -7.221 56.944 4.707 1.00 27.98 ? 191 LEU A CG 1 ATOM 1545 C CD1 . LEU A 1 191 ? -8.489 56.110 4.837 1.00 27.94 ? 191 LEU A CD1 1 ATOM 1546 C CD2 . LEU A 1 191 ? -6.361 56.442 3.560 1.00 27.94 ? 191 LEU A CD2 1 ATOM 1547 N N . SER A 1 192 ? -6.849 59.955 7.078 1.00 28.90 ? 192 SER A N 1 ATOM 1548 C CA . SER A 1 192 ? -6.075 60.092 8.305 1.00 28.80 ? 192 SER A CA 1 ATOM 1549 C C . SER A 1 192 ? -5.576 61.524 8.412 1.00 27.52 ? 192 SER A C 1 ATOM 1550 O O . SER A 1 192 ? -5.698 62.305 7.468 1.00 28.81 ? 192 SER A O 1 ATOM 1551 C CB . SER A 1 192 ? -4.896 59.120 8.318 1.00 29.41 ? 192 SER A CB 1 ATOM 1552 O OG . SER A 1 192 ? -4.283 59.104 9.595 1.00 31.58 ? 192 SER A OG 1 ATOM 1553 N N . SER A 1 193 ? -5.011 61.869 9.559 1.00 27.31 ? 193 SER A N 1 ATOM 1554 C CA . SER A 1 193 ? -4.529 63.224 9.775 1.00 27.83 ? 193 SER A CA 1 ATOM 1555 C C . SER A 1 193 ? -3.698 63.313 11.046 1.00 28.54 ? 193 SER A C 1 ATOM 1556 O O . SER A 1 193 ? -3.558 62.331 11.773 1.00 28.70 ? 193 SER A O 1 ATOM 1557 C CB . SER A 1 193 ? -5.719 64.174 9.886 1.00 27.03 ? 193 SER A CB 1 ATOM 1558 O OG . SER A 1 193 ? -6.625 63.710 10.877 1.00 26.48 ? 193 SER A OG 1 ATOM 1559 N N . ALA A 1 194 ? -3.161 64.500 11.309 1.00 28.90 ? 194 ALA A N 1 ATOM 1560 C CA . ALA A 1 194 ? -2.346 64.734 12.493 1.00 30.54 ? 194 ALA A CA 1 ATOM 1561 C C . ALA A 1 194 ? -2.270 66.233 12.769 1.00 32.04 ? 194 ALA A C 1 ATOM 1562 O O . ALA A 1 194 ? -2.111 67.034 11.845 1.00 32.00 ? 194 ALA A O 1 ATOM 1563 C CB . ALA A 1 194 ? -0.945 64.165 12.286 1.00 30.74 ? 194 ALA A CB 1 ATOM 1564 N N . ASP A 1 195 ? -2.380 66.612 14.040 1.00 31.58 ? 195 ASP A N 1 ATOM 1565 C CA . ASP A 1 195 ? -2.332 68.020 14.410 1.00 32.41 ? 195 ASP A CA 1 ATOM 1566 C C . ASP A 1 195 ? -0.965 68.663 14.259 1.00 31.30 ? 195 ASP A C 1 ATOM 1567 O O . ASP A 1 195 ? 0.069 68.023 14.455 1.00 32.19 ? 195 ASP A O 1 ATOM 1568 C CB . ASP A 1 195 ? -2.769 68.221 15.868 1.00 37.09 ? 195 ASP A CB 1 ATOM 1569 C CG . ASP A 1 195 ? -4.217 67.852 16.108 1.00 41.48 ? 195 ASP A CG 1 ATOM 1570 O OD1 . ASP A 1 195 ? -5.062 68.121 15.226 1.00 44.12 ? 195 ASP A OD1 1 ATOM 1571 O OD2 . ASP A 1 195 ? -4.513 67.309 17.195 1.00 44.16 ? 195 ASP A OD2 1 ATOM 1572 N N . ALA A 1 196 ? -0.981 69.942 13.906 1.00 28.92 ? 196 ALA A N 1 ATOM 1573 C CA . ALA A 1 196 ? 0.226 70.756 13.796 1.00 29.95 ? 196 ALA A CA 1 ATOM 1574 C C . ALA A 1 196 ? 1.439 70.171 13.083 1.00 29.72 ? 196 ALA A C 1 ATOM 1575 O O . ALA A 1 196 ? 2.569 70.373 13.531 1.00 31.83 ? 196 ALA A O 1 ATOM 1576 C CB . ALA A 1 196 ? 0.638 71.207 15.199 1.00 25.85 ? 196 ALA A CB 1 ATOM 1577 N N . THR A 1 197 ? 1.229 69.473 11.975 1.00 29.12 ? 197 THR A N 1 ATOM 1578 C CA . THR A 1 197 ? 2.354 68.895 11.248 1.00 28.85 ? 197 THR A CA 1 ATOM 1579 C C . THR A 1 197 ? 2.627 69.630 9.948 1.00 28.87 ? 197 THR A C 1 ATOM 1580 O O . THR A 1 197 ? 3.648 69.400 9.306 1.00 28.68 ? 197 THR A O 1 ATOM 1581 C CB . THR A 1 197 ? 2.099 67.422 10.894 1.00 29.01 ? 197 THR A CB 1 ATOM 1582 O OG1 . THR A 1 197 ? 0.928 67.328 10.075 1.00 27.95 ? 197 THR A OG1 1 ATOM 1583 C CG2 . THR A 1 197 ? 1.911 66.595 12.152 1.00 28.25 ? 197 THR A CG2 1 ATOM 1584 N N . GLY A 1 198 ? 1.719 70.522 9.567 1.00 29.84 ? 198 GLY A N 1 ATOM 1585 C CA . GLY A 1 198 ? 1.881 71.232 8.313 1.00 28.46 ? 198 GLY A CA 1 ATOM 1586 C C . GLY A 1 198 ? 1.334 70.335 7.212 1.00 29.40 ? 198 GLY A C 1 ATOM 1587 O O . GLY A 1 198 ? 0.851 69.231 7.485 1.00 27.52 ? 198 GLY A O 1 ATOM 1588 N N . THR A 1 199 ? 1.415 70.795 5.969 1.00 29.29 ? 199 THR A N 1 ATOM 1589 C CA . THR A 1 199 ? 0.911 70.035 4.832 1.00 27.51 ? 199 THR A CA 1 ATOM 1590 C C . THR A 1 199 ? 1.533 68.647 4.691 1.00 27.21 ? 199 THR A C 1 ATOM 1591 O O . THR A 1 199 ? 2.747 68.487 4.794 1.00 26.31 ? 199 THR A O 1 ATOM 1592 C CB . THR A 1 199 ? 1.164 70.788 3.514 1.00 29.18 ? 199 THR A CB 1 ATOM 1593 O OG1 . THR A 1 199 ? 0.595 72.100 3.594 1.00 31.51 ? 199 THR A OG1 1 ATOM 1594 C CG2 . THR A 1 199 ? 0.536 70.043 2.342 1.00 28.61 ? 199 THR A CG2 1 ATOM 1595 N N . TRP A 1 200 ? 0.688 67.647 4.459 1.00 25.40 ? 200 TRP A N 1 ATOM 1596 C CA . TRP A 1 200 ? 1.152 66.280 4.248 1.00 24.69 ? 200 TRP A CA 1 ATOM 1597 C C . TRP A 1 200 ? 1.515 66.186 2.774 1.00 25.02 ? 200 TRP A C 1 ATOM 1598 O O . TRP A 1 200 ? 0.640 66.271 1.909 1.00 26.15 ? 200 TRP A O 1 ATOM 1599 C CB . TRP A 1 200 ? 0.043 65.275 4.564 1.00 22.42 ? 200 TRP A CB 1 ATOM 1600 C CG . TRP A 1 200 ? 0.014 64.856 5.992 1.00 21.74 ? 200 TRP A CG 1 ATOM 1601 C CD1 . TRP A 1 200 ? 0.606 65.493 7.046 1.00 20.01 ? 200 TRP A CD1 1 ATOM 1602 C CD2 . TRP A 1 200 ? -0.654 63.713 6.535 1.00 21.85 ? 200 TRP A CD2 1 ATOM 1603 N NE1 . TRP A 1 200 ? 0.347 64.817 8.213 1.00 23.08 ? 200 TRP A NE1 1 ATOM 1604 C CE2 . TRP A 1 200 ? -0.424 63.720 7.930 1.00 22.63 ? 200 TRP A CE2 1 ATOM 1605 C CE3 . TRP A 1 200 ? -1.426 62.682 5.980 1.00 22.04 ? 200 TRP A CE3 1 ATOM 1606 C CZ2 . TRP A 1 200 ? -0.939 62.734 8.781 1.00 22.98 ? 200 TRP A CZ2 1 ATOM 1607 C CZ3 . TRP A 1 200 ? -1.938 61.701 6.823 1.00 22.19 ? 200 TRP A CZ3 1 ATOM 1608 C CH2 . TRP A 1 200 ? -1.691 61.737 8.214 1.00 24.16 ? 200 TRP A CH2 1 ATOM 1609 N N . GLU A 1 201 ? 2.799 66.016 2.487 1.00 22.61 ? 201 GLU A N 1 ATOM 1610 C CA . GLU A 1 201 ? 3.249 65.943 1.108 1.00 22.74 ? 201 GLU A CA 1 ATOM 1611 C C . GLU A 1 201 ? 3.434 64.516 0.582 1.00 23.46 ? 201 GLU A C 1 ATOM 1612 O O . GLU A 1 201 ? 3.905 63.625 1.301 1.00 23.60 ? 201 GLU A O 1 ATOM 1613 C CB . GLU A 1 201 ? 4.539 66.751 0.959 1.00 22.43 ? 201 GLU A CB 1 ATOM 1614 C CG . GLU A 1 201 ? 4.337 68.236 1.243 1.00 21.90 ? 201 GLU A CG 1 ATOM 1615 C CD . GLU A 1 201 ? 5.600 69.056 1.070 1.00 23.45 ? 201 GLU A CD 1 ATOM 1616 O OE1 . GLU A 1 201 ? 5.487 70.228 0.655 1.00 23.93 ? 201 GLU A OE1 1 ATOM 1617 O OE2 . GLU A 1 201 ? 6.703 68.539 1.354 1.00 23.33 ? 201 GLU A OE2 1 ATOM 1618 N N . CYS A 1 202 ? 3.046 64.312 -0.676 1.00 22.67 ? 202 CYS A N 1 ATOM 1619 C CA . CYS A 1 202 ? 3.152 63.013 -1.343 1.00 22.51 ? 202 CYS A CA 1 ATOM 1620 C C . CYS A 1 202 ? 2.681 61.856 -0.475 1.00 21.38 ? 202 CYS A C 1 ATOM 1621 O O . CYS A 1 202 ? 3.444 60.935 -0.180 1.00 21.54 ? 202 CYS A O 1 ATOM 1622 C CB . CYS A 1 202 ? 4.595 62.766 -1.782 1.00 22.49 ? 202 CYS A CB 1 ATOM 1623 S SG . CYS A 1 202 ? 5.209 64.026 -2.921 1.00 25.41 ? 202 CYS A SG 1 ATOM 1624 N N . PRO A 1 203 ? 1.412 61.891 -0.044 1.00 19.97 ? 203 PRO A N 1 ATOM 1625 C CA . PRO A 1 203 ? 0.926 60.793 0.791 1.00 20.08 ? 203 PRO A CA 1 ATOM 1626 C C . PRO A 1 203 ? 0.874 59.506 -0.018 1.00 22.07 ? 203 PRO A C 1 ATOM 1627 O O . PRO A 1 203 ? 0.684 59.536 -1.239 1.00 21.67 ? 203 PRO A O 1 ATOM 1628 C CB . PRO A 1 203 ? -0.456 61.272 1.216 1.00 17.90 ? 203 PRO A CB 1 ATOM 1629 C CG . PRO A 1 203 ? -0.898 62.082 0.031 1.00 18.10 ? 203 PRO A CG 1 ATOM 1630 C CD . PRO A 1 203 ? 0.348 62.877 -0.296 1.00 17.76 ? 203 PRO A CD 1 ATOM 1631 N N . ASP A 1 204 ? 1.064 58.379 0.658 1.00 21.22 ? 204 ASP A N 1 ATOM 1632 C CA . ASP A 1 204 ? 1.022 57.085 -0.002 1.00 21.04 ? 204 ASP A CA 1 ATOM 1633 C C . ASP A 1 204 ? 0.236 56.181 0.934 1.00 21.52 ? 204 ASP A C 1 ATOM 1634 O O . ASP A 1 204 ? 0.420 56.229 2.153 1.00 21.86 ? 204 ASP A O 1 ATOM 1635 C CB . ASP A 1 204 ? 2.444 56.549 -0.224 1.00 21.38 ? 204 ASP A CB 1 ATOM 1636 C CG . ASP A 1 204 ? 2.520 55.508 -1.343 1.00 22.89 ? 204 ASP A CG 1 ATOM 1637 O OD1 . ASP A 1 204 ? 1.508 55.305 -2.052 1.00 21.41 ? 204 ASP A OD1 1 ATOM 1638 O OD2 . ASP A 1 204 ? 3.600 54.898 -1.521 1.00 21.30 ? 204 ASP A OD2 1 ATOM 1639 N N . PHE A 1 205 ? -0.657 55.381 0.363 1.00 20.44 ? 205 PHE A N 1 ATOM 1640 C CA . PHE A 1 205 ? -1.491 54.472 1.140 1.00 20.72 ? 205 PHE A CA 1 ATOM 1641 C C . PHE A 1 205 ? -1.565 53.150 0.397 1.00 21.01 ? 205 PHE A C 1 ATOM 1642 O O . PHE A 1 205 ? -2.047 53.095 -0.736 1.00 19.76 ? 205 PHE A O 1 ATOM 1643 C CB . PHE A 1 205 ? -2.895 55.054 1.293 1.00 21.04 ? 205 PHE A CB 1 ATOM 1644 C CG . PHE A 1 205 ? -3.754 54.303 2.261 1.00 22.95 ? 205 PHE A CG 1 ATOM 1645 C CD1 . PHE A 1 205 ? -3.497 54.369 3.629 1.00 23.12 ? 205 PHE A CD1 1 ATOM 1646 C CD2 . PHE A 1 205 ? -4.818 53.521 1.811 1.00 22.67 ? 205 PHE A CD2 1 ATOM 1647 C CE1 . PHE A 1 205 ? -4.287 53.667 4.539 1.00 23.85 ? 205 PHE A CE1 1 ATOM 1648 C CE2 . PHE A 1 205 ? -5.616 52.813 2.712 1.00 22.46 ? 205 PHE A CE2 1 ATOM 1649 C CZ . PHE A 1 205 ? -5.349 52.887 4.080 1.00 23.06 ? 205 PHE A CZ 1 ATOM 1650 N N . TYR A 1 206 ? -1.107 52.080 1.037 1.00 20.84 ? 206 TYR A N 1 ATOM 1651 C CA . TYR A 1 206 ? -1.096 50.779 0.387 1.00 20.28 ? 206 TYR A CA 1 ATOM 1652 C C . TYR A 1 206 ? -1.076 49.629 1.382 1.00 21.55 ? 206 TYR A C 1 ATOM 1653 O O . TYR A 1 206 ? -0.774 49.815 2.558 1.00 21.41 ? 206 TYR A O 1 ATOM 1654 C CB . TYR A 1 206 ? 0.133 50.688 -0.516 1.00 19.11 ? 206 TYR A CB 1 ATOM 1655 C CG . TYR A 1 206 ? 1.423 50.929 0.234 1.00 19.42 ? 206 TYR A CG 1 ATOM 1656 C CD1 . TYR A 1 206 ? 2.032 49.903 0.960 1.00 18.47 ? 206 TYR A CD1 1 ATOM 1657 C CD2 . TYR A 1 206 ? 2.010 52.197 0.261 1.00 18.29 ? 206 TYR A CD2 1 ATOM 1658 C CE1 . TYR A 1 206 ? 3.191 50.132 1.697 1.00 18.08 ? 206 TYR A CE1 1 ATOM 1659 C CE2 . TYR A 1 206 ? 3.166 52.437 0.995 1.00 18.72 ? 206 TYR A CE2 1 ATOM 1660 C CZ . TYR A 1 206 ? 3.752 51.401 1.711 1.00 19.30 ? 206 TYR A CZ 1 ATOM 1661 O OH . TYR A 1 206 ? 4.895 51.630 2.442 1.00 19.97 ? 206 TYR A OH 1 ATOM 1662 N N . PRO A 1 207 ? -1.392 48.414 0.909 1.00 22.49 ? 207 PRO A N 1 ATOM 1663 C CA . PRO A 1 207 ? -1.411 47.222 1.754 1.00 22.40 ? 207 PRO A CA 1 ATOM 1664 C C . PRO A 1 207 ? -0.103 46.435 1.680 1.00 22.98 ? 207 PRO A C 1 ATOM 1665 O O . PRO A 1 207 ? 0.626 46.514 0.689 1.00 22.14 ? 207 PRO A O 1 ATOM 1666 C CB . PRO A 1 207 ? -2.562 46.427 1.165 1.00 22.27 ? 207 PRO A CB 1 ATOM 1667 C CG . PRO A 1 207 ? -2.331 46.641 -0.307 1.00 21.87 ? 207 PRO A CG 1 ATOM 1668 C CD . PRO A 1 207 ? -2.044 48.136 -0.388 1.00 21.73 ? 207 PRO A CD 1 ATOM 1669 N N . VAL A 1 208 ? 0.180 45.678 2.736 1.00 22.04 ? 208 VAL A N 1 ATOM 1670 C CA . VAL A 1 208 ? 1.361 44.827 2.791 1.00 22.02 ? 208 VAL A CA 1 ATOM 1671 C C . VAL A 1 208 ? 0.890 43.489 3.360 1.00 23.52 ? 208 VAL A C 1 ATOM 1672 O O . VAL A 1 208 ? 0.089 43.447 4.291 1.00 23.12 ? 208 VAL A O 1 ATOM 1673 C CB . VAL A 1 208 ? 2.476 45.416 3.695 1.00 21.47 ? 208 VAL A CB 1 ATOM 1674 C CG1 . VAL A 1 208 ? 3.016 46.691 3.077 1.00 20.39 ? 208 VAL A CG1 1 ATOM 1675 C CG2 . VAL A 1 208 ? 1.944 45.686 5.093 1.00 19.31 ? 208 VAL A CG2 1 ATOM 1676 N N . PRO A 1 209 ? 1.370 42.376 2.793 1.00 25.09 ? 209 PRO A N 1 ATOM 1677 C CA . PRO A 1 209 ? 0.964 41.054 3.274 1.00 25.68 ? 209 PRO A CA 1 ATOM 1678 C C . PRO A 1 209 ? 1.698 40.633 4.544 1.00 28.10 ? 209 PRO A C 1 ATOM 1679 O O . PRO A 1 209 ? 2.930 40.685 4.603 1.00 27.00 ? 209 PRO A O 1 ATOM 1680 C CB . PRO A 1 209 ? 1.299 40.157 2.092 1.00 24.53 ? 209 PRO A CB 1 ATOM 1681 C CG . PRO A 1 209 ? 2.576 40.770 1.590 1.00 25.17 ? 209 PRO A CG 1 ATOM 1682 C CD . PRO A 1 209 ? 2.301 42.265 1.653 1.00 24.72 ? 209 PRO A CD 1 ATOM 1683 N N . LEU A 1 210 ? 0.943 40.221 5.560 1.00 30.18 ? 210 LEU A N 1 ATOM 1684 C CA . LEU A 1 210 ? 1.548 39.775 6.810 1.00 33.26 ? 210 LEU A CA 1 ATOM 1685 C C . LEU A 1 210 ? 2.262 38.442 6.592 1.00 35.38 ? 210 LEU A C 1 ATOM 1686 O O . LEU A 1 210 ? 1.849 37.629 5.758 1.00 35.11 ? 210 LEU A O 1 ATOM 1687 C CB . LEU A 1 210 ? 0.484 39.623 7.904 1.00 33.47 ? 210 LEU A CB 1 ATOM 1688 C CG . LEU A 1 210 ? -0.143 40.915 8.441 1.00 35.29 ? 210 LEU A CG 1 ATOM 1689 C CD1 . LEU A 1 210 ? -1.138 40.573 9.542 1.00 33.56 ? 210 LEU A CD1 1 ATOM 1690 C CD2 . LEU A 1 210 ? 0.945 41.844 8.981 1.00 31.97 ? 210 LEU A CD2 1 ATOM 1691 N N . ASN A 1 211 ? 3.339 38.228 7.339 1.00 38.12 ? 211 ASN A N 1 ATOM 1692 C CA . ASN A 1 211 ? 4.127 37.001 7.233 1.00 42.65 ? 211 ASN A CA 1 ATOM 1693 C C . ASN A 1 211 ? 4.466 36.665 5.777 1.00 41.30 ? 211 ASN A C 1 ATOM 1694 O O . ASN A 1 211 ? 4.209 35.559 5.300 1.00 41.18 ? 211 ASN A O 1 ATOM 1695 C CB . ASN A 1 211 ? 3.383 35.817 7.866 1.00 47.28 ? 211 ASN A CB 1 ATOM 1696 C CG . ASN A 1 211 ? 4.290 34.605 8.079 1.00 53.27 ? 211 ASN A CG 1 ATOM 1697 O OD1 . ASN A 1 211 ? 3.822 33.462 8.120 1.00 55.68 ? 211 ASN A OD1 1 ATOM 1698 N ND2 . ASN A 1 211 ? 5.593 34.854 8.227 1.00 53.94 ? 211 ASN A ND2 1 ATOM 1699 N N . SER A 1 212 ? 5.046 37.635 5.080 1.00 39.53 ? 212 SER A N 1 ATOM 1700 C CA . SER A 1 212 ? 5.440 37.472 3.688 1.00 35.89 ? 212 SER A CA 1 ATOM 1701 C C . SER A 1 212 ? 6.458 38.556 3.389 1.00 34.16 ? 212 SER A C 1 ATOM 1702 O O . SER A 1 212 ? 6.415 39.624 3.992 1.00 34.54 ? 212 SER A O 1 ATOM 1703 C CB . SER A 1 212 ? 4.229 37.634 2.767 1.00 35.90 ? 212 SER A CB 1 ATOM 1704 O OG . SER A 1 212 ? 4.626 37.687 1.406 1.00 36.30 ? 212 SER A OG 1 ATOM 1705 N N . THR A 1 213 ? 7.379 38.283 2.472 1.00 31.86 ? 213 THR A N 1 ATOM 1706 C CA . THR A 1 213 ? 8.385 39.271 2.110 1.00 30.37 ? 213 THR A CA 1 ATOM 1707 C C . THR A 1 213 ? 8.090 39.795 0.708 1.00 30.73 ? 213 THR A C 1 ATOM 1708 O O . THR A 1 213 ? 8.966 40.343 0.039 1.00 31.60 ? 213 THR A O 1 ATOM 1709 C CB . THR A 1 213 ? 9.801 38.664 2.140 1.00 30.04 ? 213 THR A CB 1 ATOM 1710 O OG1 . THR A 1 213 ? 9.904 37.632 1.151 1.00 28.94 ? 213 THR A OG1 1 ATOM 1711 C CG2 . THR A 1 213 ? 10.095 38.079 3.518 1.00 27.57 ? 213 THR A CG2 1 ATOM 1712 N N . ASN A 1 214 ? 6.841 39.630 0.281 1.00 30.48 ? 214 ASN A N 1 ATOM 1713 C CA . ASN A 1 214 ? 6.393 40.059 -1.039 1.00 31.37 ? 214 ASN A CA 1 ATOM 1714 C C . ASN A 1 214 ? 5.520 41.307 -1.003 1.00 30.43 ? 214 ASN A C 1 ATOM 1715 O O . ASN A 1 214 ? 5.216 41.834 0.063 1.00 30.83 ? 214 ASN A O 1 ATOM 1716 C CB . ASN A 1 214 ? 5.611 38.927 -1.702 1.00 34.51 ? 214 ASN A CB 1 ATOM 1717 C CG . ASN A 1 214 ? 6.474 37.722 -1.998 1.00 38.09 ? 214 ASN A CG 1 ATOM 1718 O OD1 . ASN A 1 214 ? 5.976 36.601 -2.068 1.00 42.05 ? 214 ASN A OD1 1 ATOM 1719 N ND2 . ASN A 1 214 ? 7.774 37.945 -2.188 1.00 37.65 ? 214 ASN A ND2 1 ATOM 1720 N N . GLY A 1 215 ? 5.111 41.765 -2.184 1.00 29.95 ? 215 GLY A N 1 ATOM 1721 C CA . GLY A 1 215 ? 4.271 42.944 -2.276 1.00 28.77 ? 215 GLY A CA 1 ATOM 1722 C C . GLY A 1 215 ? 2.854 42.597 -2.688 1.00 29.03 ? 215 GLY A C 1 ATOM 1723 O O . GLY A 1 215 ? 2.568 41.458 -3.054 1.00 28.23 ? 215 GLY A O 1 ATOM 1724 N N . LEU A 1 216 ? 1.960 43.578 -2.628 1.00 28.43 ? 216 LEU A N 1 ATOM 1725 C CA . LEU A 1 216 ? 0.568 43.358 -3.003 1.00 28.08 ? 216 LEU A CA 1 ATOM 1726 C C . LEU A 1 216 ? 0.016 44.482 -3.858 1.00 28.52 ? 216 LEU A C 1 ATOM 1727 O O . LEU A 1 216 ? 0.401 45.644 -3.708 1.00 27.30 ? 216 LEU A O 1 ATOM 1728 C CB . LEU A 1 216 ? -0.315 43.232 -1.758 1.00 26.31 ? 216 LEU A CB 1 ATOM 1729 C CG . LEU A 1 216 ? -0.229 41.972 -0.897 1.00 27.73 ? 216 LEU A CG 1 ATOM 1730 C CD1 . LEU A 1 216 ? -1.082 42.161 0.353 1.00 22.74 ? 216 LEU A CD1 1 ATOM 1731 C CD2 . LEU A 1 216 ? -0.701 40.763 -1.704 1.00 23.70 ? 216 LEU A CD2 1 ATOM 1732 N N . ASP A 1 217 ? -0.891 44.121 -4.760 1.00 29.33 ? 217 ASP A N 1 ATOM 1733 C CA . ASP A 1 217 ? -1.548 45.098 -5.612 1.00 28.83 ? 217 ASP A CA 1 ATOM 1734 C C . ASP A 1 217 ? -2.219 46.064 -4.637 1.00 27.57 ? 217 ASP A C 1 ATOM 1735 O O . ASP A 1 217 ? -2.735 45.644 -3.605 1.00 27.42 ? 217 ASP A O 1 ATOM 1736 C CB . ASP A 1 217 ? -2.609 44.413 -6.473 1.00 30.43 ? 217 ASP A CB 1 ATOM 1737 C CG . ASP A 1 217 ? -3.424 45.399 -7.275 1.00 33.29 ? 217 ASP A CG 1 ATOM 1738 O OD1 . ASP A 1 217 ? -2.858 46.016 -8.202 1.00 35.33 ? 217 ASP A OD1 1 ATOM 1739 O OD2 . ASP A 1 217 ? -4.624 45.570 -6.967 1.00 33.12 ? 217 ASP A OD2 1 ATOM 1740 N N . THR A 1 218 ? -2.222 47.349 -4.959 1.00 27.31 ? 218 THR A N 1 ATOM 1741 C CA . THR A 1 218 ? -2.812 48.344 -4.068 1.00 28.27 ? 218 THR A CA 1 ATOM 1742 C C . THR A 1 218 ? -4.261 48.078 -3.649 1.00 29.03 ? 218 THR A C 1 ATOM 1743 O O . THR A 1 218 ? -4.706 48.576 -2.618 1.00 28.80 ? 218 THR A O 1 ATOM 1744 C CB . THR A 1 218 ? -2.737 49.745 -4.695 1.00 27.03 ? 218 THR A CB 1 ATOM 1745 O OG1 . THR A 1 218 ? -1.417 49.962 -5.203 1.00 29.87 ? 218 THR A OG1 1 ATOM 1746 C CG2 . THR A 1 218 ? -3.033 50.811 -3.654 1.00 24.11 ? 218 THR A CG2 1 ATOM 1747 N N . SER A 1 219 ? -4.989 47.282 -4.425 1.00 30.41 ? 219 SER A N 1 ATOM 1748 C CA . SER A 1 219 ? -6.391 47.011 -4.112 1.00 31.29 ? 219 SER A CA 1 ATOM 1749 C C . SER A 1 219 ? -6.719 45.783 -3.262 1.00 32.86 ? 219 SER A C 1 ATOM 1750 O O . SER A 1 219 ? -7.895 45.475 -3.047 1.00 34.18 ? 219 SER A O 1 ATOM 1751 C CB . SER A 1 219 ? -7.201 46.949 -5.407 1.00 29.05 ? 219 SER A CB 1 ATOM 1752 O OG . SER A 1 219 ? -7.247 48.220 -6.027 1.00 26.84 ? 219 SER A OG 1 ATOM 1753 N N . VAL A 1 220 ? -5.708 45.080 -2.769 1.00 33.86 ? 220 VAL A N 1 ATOM 1754 C CA . VAL A 1 220 ? -5.980 43.906 -1.950 1.00 36.14 ? 220 VAL A CA 1 ATOM 1755 C C . VAL A 1 220 ? -6.291 44.289 -0.498 1.00 37.55 ? 220 VAL A C 1 ATOM 1756 O O . VAL A 1 220 ? -5.717 45.225 0.052 1.00 37.91 ? 220 VAL A O 1 ATOM 1757 C CB . VAL A 1 220 ? -4.796 42.906 -2.006 1.00 35.54 ? 220 VAL A CB 1 ATOM 1758 C CG1 . VAL A 1 220 ? -3.500 43.635 -1.770 1.00 40.88 ? 220 VAL A CG1 1 ATOM 1759 C CG2 . VAL A 1 220 ? -4.973 41.815 -0.965 1.00 33.35 ? 220 VAL A CG2 1 ATOM 1760 N N . TYR A 1 221 ? -7.226 43.565 0.106 1.00 39.82 ? 221 TYR A N 1 ATOM 1761 C CA . TYR A 1 221 ? -7.633 43.804 1.488 1.00 42.81 ? 221 TYR A CA 1 ATOM 1762 C C . TYR A 1 221 ? -7.851 42.444 2.147 1.00 41.68 ? 221 TYR A C 1 ATOM 1763 O O . TYR A 1 221 ? -7.879 41.422 1.465 1.00 42.51 ? 221 TYR A O 1 ATOM 1764 C CB . TYR A 1 221 ? -8.928 44.624 1.513 1.00 47.54 ? 221 TYR A CB 1 ATOM 1765 C CG . TYR A 1 221 ? -10.056 43.961 0.759 1.00 54.35 ? 221 TYR A CG 1 ATOM 1766 C CD1 . TYR A 1 221 ? -10.819 42.950 1.351 1.00 56.71 ? 221 TYR A CD1 1 ATOM 1767 C CD2 . TYR A 1 221 ? -10.319 44.291 -0.574 1.00 56.76 ? 221 TYR A CD2 1 ATOM 1768 C CE1 . TYR A 1 221 ? -11.814 42.279 0.635 1.00 58.65 ? 221 TYR A CE1 1 ATOM 1769 C CE2 . TYR A 1 221 ? -11.312 43.625 -1.301 1.00 59.08 ? 221 TYR A CE2 1 ATOM 1770 C CZ . TYR A 1 221 ? -12.053 42.619 -0.689 1.00 60.15 ? 221 TYR A CZ 1 ATOM 1771 O OH . TYR A 1 221 ? -13.022 41.947 -1.401 1.00 61.25 ? 221 TYR A OH 1 ATOM 1772 N N . GLY A 1 222 ? -8.003 42.425 3.465 1.00 41.13 ? 222 GLY A N 1 ATOM 1773 C CA . GLY A 1 222 ? -8.206 41.159 4.145 1.00 40.72 ? 222 GLY A CA 1 ATOM 1774 C C . GLY A 1 222 ? -7.550 41.123 5.507 1.00 40.58 ? 222 GLY A C 1 ATOM 1775 O O . GLY A 1 222 ? -6.728 41.981 5.830 1.00 41.33 ? 222 GLY A O 1 ATOM 1776 N N . GLY A 1 223 ? -7.909 40.124 6.306 1.00 39.83 ? 223 GLY A N 1 ATOM 1777 C CA . GLY A 1 223 ? -7.357 40.007 7.643 1.00 38.91 ? 223 GLY A CA 1 ATOM 1778 C C . GLY A 1 223 ? -5.865 39.751 7.678 1.00 38.64 ? 223 GLY A C 1 ATOM 1779 O O . GLY A 1 223 ? -5.193 40.091 8.649 1.00 39.73 ? 223 GLY A O 1 ATOM 1780 N N . SER A 1 224 ? -5.347 39.144 6.618 1.00 37.81 ? 224 SER A N 1 ATOM 1781 C CA . SER A 1 224 ? -3.924 38.840 6.528 1.00 38.63 ? 224 SER A CA 1 ATOM 1782 C C . SER A 1 224 ? -3.184 39.993 5.855 1.00 36.80 ? 224 SER A C 1 ATOM 1783 O O . SER A 1 224 ? -2.085 39.824 5.330 1.00 36.53 ? 224 SER A O 1 ATOM 1784 C CB . SER A 1 224 ? -3.728 37.563 5.717 1.00 40.14 ? 224 SER A CB 1 ATOM 1785 O OG . SER A 1 224 ? -4.386 37.683 4.463 1.00 44.71 ? 224 SER A OG 1 ATOM 1786 N N . VAL A 1 225 ? -3.801 41.167 5.880 1.00 35.55 ? 225 VAL A N 1 ATOM 1787 C CA . VAL A 1 225 ? -3.223 42.352 5.267 1.00 34.11 ? 225 VAL A CA 1 ATOM 1788 C C . VAL A 1 225 ? -3.313 43.551 6.199 1.00 33.50 ? 225 VAL A C 1 ATOM 1789 O O . VAL A 1 225 ? -4.286 43.710 6.935 1.00 34.67 ? 225 VAL A O 1 ATOM 1790 C CB . VAL A 1 225 ? -3.966 42.709 3.957 1.00 34.37 ? 225 VAL A CB 1 ATOM 1791 C CG1 . VAL A 1 225 ? -3.459 44.024 3.406 1.00 31.90 ? 225 VAL A CG1 1 ATOM 1792 C CG2 . VAL A 1 225 ? -3.788 41.597 2.940 1.00 32.78 ? 225 VAL A CG2 1 ATOM 1793 N N . ARG A 1 226 ? -2.285 44.388 6.168 1.00 31.38 ? 226 ARG A N 1 ATOM 1794 C CA . ARG A 1 226 ? -2.269 45.601 6.970 1.00 29.14 ? 226 ARG A CA 1 ATOM 1795 C C . ARG A 1 226 ? -1.975 46.735 6.003 1.00 27.23 ? 226 ARG A C 1 ATOM 1796 O O . ARG A 1 226 ? -1.438 46.499 4.916 1.00 24.87 ? 226 ARG A O 1 ATOM 1797 C CB . ARG A 1 226 ? -1.196 45.521 8.057 1.00 29.73 ? 226 ARG A CB 1 ATOM 1798 C CG . ARG A 1 226 ? -1.562 44.587 9.202 1.00 31.63 ? 226 ARG A CG 1 ATOM 1799 C CD . ARG A 1 226 ? -2.794 45.085 9.949 1.00 33.81 ? 226 ARG A CD 1 ATOM 1800 N NE . ARG A 1 226 ? -3.221 44.160 11.001 1.00 36.86 ? 226 ARG A NE 1 ATOM 1801 C CZ . ARG A 1 226 ? -3.876 43.021 10.785 1.00 38.45 ? 226 ARG A CZ 1 ATOM 1802 N NH1 . ARG A 1 226 ? -4.194 42.649 9.551 1.00 36.98 ? 226 ARG A NH1 1 ATOM 1803 N NH2 . ARG A 1 226 ? -4.213 42.246 11.808 1.00 38.94 ? 226 ARG A NH2 1 ATOM 1804 N N . HIS A 1 227 ? -2.338 47.958 6.379 1.00 25.05 ? 227 HIS A N 1 ATOM 1805 C CA . HIS A 1 227 ? -2.097 49.097 5.503 1.00 25.06 ? 227 HIS A CA 1 ATOM 1806 C C . HIS A 1 227 ? -1.100 50.101 6.053 1.00 25.63 ? 227 HIS A C 1 ATOM 1807 O O . HIS A 1 227 ? -0.957 50.269 7.269 1.00 25.96 ? 227 HIS A O 1 ATOM 1808 C CB . HIS A 1 227 ? -3.410 49.812 5.171 1.00 24.98 ? 227 HIS A CB 1 ATOM 1809 C CG . HIS A 1 227 ? -4.185 49.169 4.064 1.00 25.66 ? 227 HIS A CG 1 ATOM 1810 N ND1 . HIS A 1 227 ? -4.797 47.939 4.197 1.00 25.86 ? 227 HIS A ND1 1 ATOM 1811 C CD2 . HIS A 1 227 ? -4.429 49.576 2.795 1.00 24.06 ? 227 HIS A CD2 1 ATOM 1812 C CE1 . HIS A 1 227 ? -5.384 47.618 3.057 1.00 26.49 ? 227 HIS A CE1 1 ATOM 1813 N NE2 . HIS A 1 227 ? -5.176 48.594 2.190 1.00 25.83 ? 227 HIS A NE2 1 ATOM 1814 N N . VAL A 1 228 ? -0.404 50.762 5.136 1.00 23.67 ? 228 VAL A N 1 ATOM 1815 C CA . VAL A 1 228 ? 0.582 51.757 5.501 1.00 23.18 ? 228 VAL A CA 1 ATOM 1816 C C . VAL A 1 228 ? 0.114 53.134 5.061 1.00 23.63 ? 228 VAL A C 1 ATOM 1817 O O . VAL A 1 228 ? -0.259 53.336 3.903 1.00 24.86 ? 228 VAL A O 1 ATOM 1818 C CB . VAL A 1 228 ? 1.945 51.473 4.828 1.00 22.84 ? 228 VAL A CB 1 ATOM 1819 C CG1 . VAL A 1 228 ? 2.967 52.523 5.251 1.00 20.22 ? 228 VAL A CG1 1 ATOM 1820 C CG2 . VAL A 1 228 ? 2.427 50.084 5.192 1.00 21.35 ? 228 VAL A CG2 1 ATOM 1821 N N . MET A 1 229 ? 0.113 54.072 6.000 1.00 22.98 ? 229 MET A N 1 ATOM 1822 C CA . MET A 1 229 ? -0.256 55.449 5.717 1.00 21.53 ? 229 MET A CA 1 ATOM 1823 C C . MET A 1 229 ? 1.085 56.170 5.777 1.00 22.38 ? 229 MET A C 1 ATOM 1824 O O . MET A 1 229 ? 1.724 56.222 6.832 1.00 22.40 ? 229 MET A O 1 ATOM 1825 C CB . MET A 1 229 ? -1.194 55.993 6.794 1.00 22.53 ? 229 MET A CB 1 ATOM 1826 C CG . MET A 1 229 ? -1.536 57.473 6.655 1.00 22.22 ? 229 MET A CG 1 ATOM 1827 S SD . MET A 1 229 ? -2.603 57.857 5.234 1.00 27.75 ? 229 MET A SD 1 ATOM 1828 C CE . MET A 1 229 ? -1.432 58.616 4.124 1.00 23.34 ? 229 MET A CE 1 ATOM 1829 N N . LYS A 1 230 ? 1.526 56.691 4.638 1.00 21.99 ? 230 LYS A N 1 ATOM 1830 C CA . LYS A 1 230 ? 2.798 57.394 4.557 1.00 20.63 ? 230 LYS A CA 1 ATOM 1831 C C . LYS A 1 230 ? 2.567 58.844 4.173 1.00 21.87 ? 230 LYS A C 1 ATOM 1832 O O . LYS A 1 230 ? 1.719 59.142 3.335 1.00 23.01 ? 230 LYS A O 1 ATOM 1833 C CB . LYS A 1 230 ? 3.697 56.710 3.523 1.00 18.54 ? 230 LYS A CB 1 ATOM 1834 C CG . LYS A 1 230 ? 5.001 57.429 3.230 1.00 19.09 ? 230 LYS A CG 1 ATOM 1835 C CD . LYS A 1 230 ? 4.825 58.505 2.178 1.00 21.54 ? 230 LYS A CD 1 ATOM 1836 C CE . LYS A 1 230 ? 6.089 59.333 2.021 1.00 22.32 ? 230 LYS A CE 1 ATOM 1837 N NZ . LYS A 1 230 ? 5.961 60.331 0.931 1.00 21.49 ? 230 LYS A NZ 1 ATOM 1838 N N . ALA A 1 231 ? 3.324 59.745 4.788 1.00 21.64 ? 231 ALA A N 1 ATOM 1839 C CA . ALA A 1 231 ? 3.196 61.163 4.494 1.00 22.00 ? 231 ALA A CA 1 ATOM 1840 C C . ALA A 1 231 ? 4.486 61.905 4.801 1.00 22.59 ? 231 ALA A C 1 ATOM 1841 O O . ALA A 1 231 ? 5.210 61.568 5.744 1.00 21.64 ? 231 ALA A O 1 ATOM 1842 C CB . ALA A 1 231 ? 2.047 61.769 5.296 1.00 21.11 ? 231 ALA A CB 1 ATOM 1843 N N . GLY A 1 232 ? 4.773 62.911 3.987 1.00 22.29 ? 232 GLY A N 1 ATOM 1844 C CA . GLY A 1 232 ? 5.962 63.704 4.203 1.00 24.45 ? 232 GLY A CA 1 ATOM 1845 C C . GLY A 1 232 ? 5.581 65.029 4.841 1.00 25.24 ? 232 GLY A C 1 ATOM 1846 O O . GLY A 1 232 ? 4.678 65.716 4.367 1.00 25.47 ? 232 GLY A O 1 ATOM 1847 N N . PHE A 1 233 ? 6.244 65.369 5.940 1.00 24.99 ? 233 PHE A N 1 ATOM 1848 C CA . PHE A 1 233 ? 6.002 66.630 6.627 1.00 25.83 ? 233 PHE A CA 1 ATOM 1849 C C . PHE A 1 233 ? 7.150 66.924 7.584 1.00 26.26 ? 233 PHE A C 1 ATOM 1850 O O . PHE A 1 233 ? 7.851 66.013 8.042 1.00 25.66 ? 233 PHE A O 1 ATOM 1851 C CB . PHE A 1 233 ? 4.646 66.622 7.359 1.00 24.75 ? 233 PHE A CB 1 ATOM 1852 C CG . PHE A 1 233 ? 4.544 65.617 8.471 1.00 25.51 ? 233 PHE A CG 1 ATOM 1853 C CD1 . PHE A 1 233 ? 5.115 65.870 9.714 1.00 25.31 ? 233 PHE A CD1 1 ATOM 1854 C CD2 . PHE A 1 233 ? 3.858 64.419 8.280 1.00 26.30 ? 233 PHE A CD2 1 ATOM 1855 C CE1 . PHE A 1 233 ? 5.003 64.944 10.754 1.00 24.95 ? 233 PHE A CE1 1 ATOM 1856 C CE2 . PHE A 1 233 ? 3.741 63.489 9.310 1.00 26.30 ? 233 PHE A CE2 1 ATOM 1857 C CZ . PHE A 1 233 ? 4.316 63.753 10.551 1.00 25.58 ? 233 PHE A CZ 1 ATOM 1858 N N . GLU A 1 234 ? 7.349 68.204 7.867 1.00 25.84 ? 234 GLU A N 1 ATOM 1859 C CA . GLU A 1 234 ? 8.427 68.628 8.741 1.00 25.76 ? 234 GLU A CA 1 ATOM 1860 C C . GLU A 1 234 ? 9.781 68.139 8.225 1.00 24.40 ? 234 GLU A C 1 ATOM 1861 O O . GLU A 1 234 ? 10.694 67.855 9.001 1.00 24.16 ? 234 GLU A O 1 ATOM 1862 C CB . GLU A 1 234 ? 8.163 68.156 10.177 1.00 27.14 ? 234 GLU A CB 1 ATOM 1863 C CG . GLU A 1 234 ? 7.089 69.000 10.863 1.00 29.76 ? 234 GLU A CG 1 ATOM 1864 C CD . GLU A 1 234 ? 6.725 68.532 12.262 1.00 31.52 ? 234 GLU A CD 1 ATOM 1865 O OE1 . GLU A 1 234 ? 5.926 69.225 12.921 1.00 33.70 ? 234 GLU A OE1 1 ATOM 1866 O OE2 . GLU A 1 234 ? 7.222 67.480 12.707 1.00 34.30 ? 234 GLU A OE2 1 ATOM 1867 N N . GLY A 1 235 ? 9.887 68.036 6.901 1.00 23.40 ? 235 GLY A N 1 ATOM 1868 C CA . GLY A 1 235 ? 11.130 67.639 6.259 1.00 21.78 ? 235 GLY A CA 1 ATOM 1869 C C . GLY A 1 235 ? 11.483 66.170 6.119 1.00 22.94 ? 235 GLY A C 1 ATOM 1870 O O . GLY A 1 235 ? 12.563 65.850 5.623 1.00 24.27 ? 235 GLY A O 1 ATOM 1871 N N . HIS A 1 236 ? 10.597 65.271 6.530 1.00 22.47 ? 236 HIS A N 1 ATOM 1872 C CA . HIS A 1 236 ? 10.897 63.848 6.435 1.00 22.02 ? 236 HIS A CA 1 ATOM 1873 C C . HIS A 1 236 ? 9.688 63.015 6.057 1.00 21.94 ? 236 HIS A C 1 ATOM 1874 O O . HIS A 1 236 ? 8.550 63.475 6.144 1.00 23.09 ? 236 HIS A O 1 ATOM 1875 C CB . HIS A 1 236 ? 11.452 63.342 7.769 1.00 19.72 ? 236 HIS A CB 1 ATOM 1876 C CG . HIS A 1 236 ? 12.732 63.997 8.178 1.00 22.37 ? 236 HIS A CG 1 ATOM 1877 N ND1 . HIS A 1 236 ? 12.899 64.606 9.403 1.00 24.10 ? 236 HIS A ND1 1 ATOM 1878 C CD2 . HIS A 1 236 ? 13.910 64.136 7.525 1.00 21.52 ? 236 HIS A CD2 1 ATOM 1879 C CE1 . HIS A 1 236 ? 14.124 65.095 9.487 1.00 22.15 ? 236 HIS A CE1 1 ATOM 1880 N NE2 . HIS A 1 236 ? 14.758 64.823 8.360 1.00 21.39 ? 236 HIS A NE2 1 ATOM 1881 N N . ASP A 1 237 ? 9.946 61.784 5.630 1.00 21.48 ? 237 ASP A N 1 ATOM 1882 C CA . ASP A 1 237 ? 8.877 60.869 5.265 1.00 21.21 ? 237 ASP A CA 1 ATOM 1883 C C . ASP A 1 237 ? 8.589 59.953 6.444 1.00 21.26 ? 237 ASP A C 1 ATOM 1884 O O . ASP A 1 237 ? 9.463 59.217 6.904 1.00 21.69 ? 237 ASP A O 1 ATOM 1885 C CB . ASP A 1 237 ? 9.269 60.036 4.044 1.00 21.70 ? 237 ASP A CB 1 ATOM 1886 C CG . ASP A 1 237 ? 9.128 60.804 2.741 1.00 24.21 ? 237 ASP A CG 1 ATOM 1887 O OD1 . ASP A 1 237 ? 8.690 61.974 2.782 1.00 24.26 ? 237 ASP A OD1 1 ATOM 1888 O OD2 . ASP A 1 237 ? 9.451 60.230 1.674 1.00 23.58 ? 237 ASP A OD2 1 ATOM 1889 N N . TRP A 1 238 ? 7.357 60.011 6.937 1.00 20.65 ? 238 TRP A N 1 ATOM 1890 C CA . TRP A 1 238 ? 6.953 59.188 8.065 1.00 20.65 ? 238 TRP A CA 1 ATOM 1891 C C . TRP A 1 238 ? 5.896 58.210 7.595 1.00 20.17 ? 238 TRP A C 1 ATOM 1892 O O . TRP A 1 238 ? 5.268 58.413 6.556 1.00 21.91 ? 238 TRP A O 1 ATOM 1893 C CB . TRP A 1 238 ? 6.364 60.057 9.185 1.00 19.72 ? 238 TRP A CB 1 ATOM 1894 C CG . TRP A 1 238 ? 7.155 61.292 9.469 1.00 20.14 ? 238 TRP A CG 1 ATOM 1895 C CD1 . TRP A 1 238 ? 7.098 62.481 8.792 1.00 18.54 ? 238 TRP A CD1 1 ATOM 1896 C CD2 . TRP A 1 238 ? 8.155 61.453 10.481 1.00 19.02 ? 238 TRP A CD2 1 ATOM 1897 N NE1 . TRP A 1 238 ? 8.003 63.369 9.321 1.00 19.87 ? 238 TRP A NE1 1 ATOM 1898 C CE2 . TRP A 1 238 ? 8.665 62.765 10.359 1.00 19.21 ? 238 TRP A CE2 1 ATOM 1899 C CE3 . TRP A 1 238 ? 8.671 60.616 11.480 1.00 20.77 ? 238 TRP A CE3 1 ATOM 1900 C CZ2 . TRP A 1 238 ? 9.669 63.262 11.199 1.00 18.93 ? 238 TRP A CZ2 1 ATOM 1901 C CZ3 . TRP A 1 238 ? 9.672 61.111 12.318 1.00 21.86 ? 238 TRP A CZ3 1 ATOM 1902 C CH2 . TRP A 1 238 ? 10.158 62.425 12.168 1.00 19.75 ? 238 TRP A CH2 1 ATOM 1903 N N . TYR A 1 239 ? 5.707 57.142 8.354 1.00 18.92 ? 239 TYR A N 1 ATOM 1904 C CA . TYR A 1 239 ? 4.693 56.167 8.009 1.00 20.60 ? 239 TYR A CA 1 ATOM 1905 C C . TYR A 1 239 ? 4.230 55.461 9.270 1.00 22.06 ? 239 TYR A C 1 ATOM 1906 O O . TYR A 1 239 ? 4.938 55.433 10.278 1.00 21.88 ? 239 TYR A O 1 ATOM 1907 C CB . TYR A 1 239 ? 5.226 55.154 6.978 1.00 18.06 ? 239 TYR A CB 1 ATOM 1908 C CG . TYR A 1 239 ? 6.165 54.094 7.516 1.00 18.22 ? 239 TYR A CG 1 ATOM 1909 C CD1 . TYR A 1 239 ? 5.674 52.977 8.195 1.00 18.18 ? 239 TYR A CD1 1 ATOM 1910 C CD2 . TYR A 1 239 ? 7.544 54.191 7.318 1.00 18.16 ? 239 TYR A CD2 1 ATOM 1911 C CE1 . TYR A 1 239 ? 6.535 51.977 8.659 1.00 20.07 ? 239 TYR A CE1 1 ATOM 1912 C CE2 . TYR A 1 239 ? 8.414 53.200 7.777 1.00 18.67 ? 239 TYR A CE2 1 ATOM 1913 C CZ . TYR A 1 239 ? 7.904 52.097 8.445 1.00 21.23 ? 239 TYR A CZ 1 ATOM 1914 O OH . TYR A 1 239 ? 8.758 51.116 8.894 1.00 21.66 ? 239 TYR A OH 1 ATOM 1915 N N . THR A 1 240 ? 3.024 54.913 9.210 1.00 22.81 ? 240 THR A N 1 ATOM 1916 C CA . THR A 1 240 ? 2.461 54.186 10.328 1.00 23.79 ? 240 THR A CA 1 ATOM 1917 C C . THR A 1 240 ? 1.689 52.995 9.766 1.00 24.78 ? 240 THR A C 1 ATOM 1918 O O . THR A 1 240 ? 1.014 53.101 8.737 1.00 24.84 ? 240 THR A O 1 ATOM 1919 C CB . THR A 1 240 ? 1.530 55.088 11.177 1.00 23.69 ? 240 THR A CB 1 ATOM 1920 O OG1 . THR A 1 240 ? 0.904 54.298 12.192 1.00 25.80 ? 240 THR A OG1 1 ATOM 1921 C CG2 . THR A 1 240 ? 0.462 55.742 10.315 1.00 23.87 ? 240 THR A CG2 1 ATOM 1922 N N . ILE A 1 241 ? 1.825 51.854 10.432 1.00 24.66 ? 241 ILE A N 1 ATOM 1923 C CA . ILE A 1 241 ? 1.160 50.625 10.023 1.00 23.84 ? 241 ILE A CA 1 ATOM 1924 C C . ILE A 1 241 ? -0.174 50.524 10.753 1.00 26.03 ? 241 ILE A C 1 ATOM 1925 O O . ILE A 1 241 ? -0.262 50.827 11.945 1.00 27.13 ? 241 ILE A O 1 ATOM 1926 C CB . ILE A 1 241 ? 2.051 49.401 10.352 1.00 22.49 ? 241 ILE A CB 1 ATOM 1927 C CG1 . ILE A 1 241 ? 3.308 49.439 9.472 1.00 22.27 ? 241 ILE A CG1 1 ATOM 1928 C CG2 . ILE A 1 241 ? 1.280 48.103 10.143 1.00 20.64 ? 241 ILE A CG2 1 ATOM 1929 C CD1 . ILE A 1 241 ? 4.368 48.397 9.834 1.00 20.53 ? 241 ILE A CD1 1 ATOM 1930 N N . GLY A 1 242 ? -1.215 50.111 10.040 1.00 26.07 ? 242 GLY A N 1 ATOM 1931 C CA . GLY A 1 242 ? -2.515 50.001 10.671 1.00 26.72 ? 242 GLY A CA 1 ATOM 1932 C C . GLY A 1 242 ? -3.504 49.146 9.908 1.00 28.14 ? 242 GLY A C 1 ATOM 1933 O O . GLY A 1 242 ? -3.135 48.404 8.996 1.00 27.92 ? 242 GLY A O 1 ATOM 1934 N N . THR A 1 243 ? -4.773 49.262 10.288 1.00 28.58 ? 243 THR A N 1 ATOM 1935 C CA . THR A 1 243 ? -5.844 48.499 9.669 1.00 29.12 ? 243 THR A CA 1 ATOM 1936 C C . THR A 1 243 ? -6.797 49.429 8.932 1.00 29.97 ? 243 THR A C 1 ATOM 1937 O O . THR A 1 243 ? -7.188 50.476 9.452 1.00 28.75 ? 243 THR A O 1 ATOM 1938 C CB . THR A 1 243 ? -6.629 47.710 10.733 1.00 30.22 ? 243 THR A CB 1 ATOM 1939 O OG1 . THR A 1 243 ? -5.725 46.857 11.446 1.00 30.94 ? 243 THR A OG1 1 ATOM 1940 C CG2 . THR A 1 243 ? -7.722 46.858 10.081 1.00 27.94 ? 243 THR A CG2 1 ATOM 1941 N N . TYR A 1 244 ? -7.170 49.032 7.720 1.00 31.14 ? 244 TYR A N 1 ATOM 1942 C CA . TYR A 1 244 ? -8.063 49.827 6.886 1.00 33.22 ? 244 TYR A CA 1 ATOM 1943 C C . TYR A 1 244 ? -9.436 49.194 6.691 1.00 35.54 ? 244 TYR A C 1 ATOM 1944 O O . TYR A 1 244 ? -9.549 48.052 6.246 1.00 35.76 ? 244 TYR A O 1 ATOM 1945 C CB . TYR A 1 244 ? -7.407 50.061 5.523 1.00 31.43 ? 244 TYR A CB 1 ATOM 1946 C CG . TYR A 1 244 ? -8.299 50.706 4.487 1.00 31.09 ? 244 TYR A CG 1 ATOM 1947 C CD1 . TYR A 1 244 ? -8.942 51.919 4.740 1.00 30.94 ? 244 TYR A CD1 1 ATOM 1948 C CD2 . TYR A 1 244 ? -8.464 50.123 3.231 1.00 30.72 ? 244 TYR A CD2 1 ATOM 1949 C CE1 . TYR A 1 244 ? -9.721 52.537 3.763 1.00 30.66 ? 244 TYR A CE1 1 ATOM 1950 C CE2 . TYR A 1 244 ? -9.239 50.731 2.249 1.00 30.76 ? 244 TYR A CE2 1 ATOM 1951 C CZ . TYR A 1 244 ? -9.863 51.936 2.518 1.00 31.53 ? 244 TYR A CZ 1 ATOM 1952 O OH . TYR A 1 244 ? -10.616 52.539 1.536 1.00 30.75 ? 244 TYR A OH 1 ATOM 1953 N N . SER A 1 245 ? -10.475 49.952 7.034 1.00 38.65 ? 245 SER A N 1 ATOM 1954 C CA . SER A 1 245 ? -11.858 49.507 6.882 1.00 42.35 ? 245 SER A CA 1 ATOM 1955 C C . SER A 1 245 ? -12.496 50.359 5.788 1.00 43.93 ? 245 SER A C 1 ATOM 1956 O O . SER A 1 245 ? -12.985 51.456 6.054 1.00 42.56 ? 245 SER A O 1 ATOM 1957 C CB . SER A 1 245 ? -12.633 49.710 8.184 1.00 43.73 ? 245 SER A CB 1 ATOM 1958 O OG . SER A 1 245 ? -12.013 49.030 9.257 1.00 49.01 ? 245 SER A OG 1 ATOM 1959 N N . PRO A 1 246 ? -12.501 49.859 4.542 1.00 46.15 ? 246 PRO A N 1 ATOM 1960 C CA . PRO A 1 246 ? -13.077 50.582 3.402 1.00 49.02 ? 246 PRO A CA 1 ATOM 1961 C C . PRO A 1 246 ? -14.520 51.027 3.626 1.00 52.06 ? 246 PRO A C 1 ATOM 1962 O O . PRO A 1 246 ? -14.920 52.119 3.212 1.00 51.85 ? 246 PRO A O 1 ATOM 1963 C CB . PRO A 1 246 ? -12.945 49.577 2.256 1.00 47.73 ? 246 PRO A CB 1 ATOM 1964 C CG . PRO A 1 246 ? -13.033 48.258 2.955 1.00 47.22 ? 246 PRO A CG 1 ATOM 1965 C CD . PRO A 1 246 ? -12.158 48.477 4.164 1.00 46.32 ? 246 PRO A CD 1 ATOM 1966 N N . ASP A 1 247 ? -15.292 50.170 4.283 1.00 55.63 ? 247 ASP A N 1 ATOM 1967 C CA . ASP A 1 247 ? -16.691 50.450 4.576 1.00 58.64 ? 247 ASP A CA 1 ATOM 1968 C C . ASP A 1 247 ? -16.865 51.763 5.336 1.00 58.61 ? 247 ASP A C 1 ATOM 1969 O O . ASP A 1 247 ? -17.754 52.557 5.019 1.00 59.03 ? 247 ASP A O 1 ATOM 1970 C CB . ASP A 1 247 ? -17.287 49.293 5.383 1.00 62.37 ? 247 ASP A CB 1 ATOM 1971 C CG . ASP A 1 247 ? -16.374 48.842 6.513 1.00 67.81 ? 247 ASP A CG 1 ATOM 1972 O OD1 . ASP A 1 247 ? -15.275 48.314 6.222 1.00 68.63 ? 247 ASP A OD1 1 ATOM 1973 O OD2 . ASP A 1 247 ? -16.753 49.019 7.694 1.00 71.25 ? 247 ASP A OD2 1 ATOM 1974 N N . ARG A 1 248 ? -16.013 51.994 6.331 1.00 57.41 ? 248 ARG A N 1 ATOM 1975 C CA . ARG A 1 248 ? -16.094 53.214 7.126 1.00 56.14 ? 248 ARG A CA 1 ATOM 1976 C C . ARG A 1 248 ? -15.011 54.212 6.736 1.00 53.41 ? 248 ARG A C 1 ATOM 1977 O O . ARG A 1 248 ? -14.923 55.297 7.316 1.00 52.37 ? 248 ARG A O 1 ATOM 1978 C CB . ARG A 1 248 ? -15.944 52.887 8.614 1.00 60.49 ? 248 ARG A CB 1 ATOM 1979 C CG . ARG A 1 248 ? -16.806 51.737 9.109 1.00 65.54 ? 248 ARG A CG 1 ATOM 1980 C CD . ARG A 1 248 ? -16.856 51.702 10.637 1.00 70.14 ? 248 ARG A CD 1 ATOM 1981 N NE . ARG A 1 248 ? -15.534 51.602 11.260 1.00 73.85 ? 248 ARG A NE 1 ATOM 1982 C CZ . ARG A 1 248 ? -14.746 50.530 11.197 1.00 75.61 ? 248 ARG A CZ 1 ATOM 1983 N NH1 . ARG A 1 248 ? -15.138 49.448 10.534 1.00 76.52 ? 248 ARG A NH1 1 ATOM 1984 N NH2 . ARG A 1 248 ? -13.564 50.538 11.804 1.00 74.63 ? 248 ARG A NH2 1 ATOM 1985 N N . GLU A 1 249 ? -14.195 53.846 5.750 1.00 49.84 ? 249 GLU A N 1 ATOM 1986 C CA . GLU A 1 249 ? -13.093 54.696 5.310 1.00 46.06 ? 249 GLU A CA 1 ATOM 1987 C C . GLU A 1 249 ? -12.295 55.081 6.545 1.00 44.00 ? 249 GLU A C 1 ATOM 1988 O O . GLU A 1 249 ? -11.935 56.243 6.751 1.00 43.69 ? 249 GLU A O 1 ATOM 1989 C CB . GLU A 1 249 ? -13.622 55.941 4.599 1.00 45.20 ? 249 GLU A CB 1 ATOM 1990 C CG . GLU A 1 249 ? -14.309 55.634 3.280 1.00 45.80 ? 249 GLU A CG 1 ATOM 1991 C CD . GLU A 1 249 ? -13.423 54.855 2.310 1.00 44.82 ? 249 GLU A CD 1 ATOM 1992 O OE1 . GLU A 1 249 ? -13.899 54.542 1.202 1.00 44.94 ? 249 GLU A OE1 1 ATOM 1993 O OE2 . GLU A 1 249 ? -12.258 54.552 2.645 1.00 43.79 ? 249 GLU A OE2 1 ATOM 1994 N N . ASN A 1 250 ? -12.022 54.073 7.362 1.00 41.68 ? 250 ASN A N 1 ATOM 1995 C CA . ASN A 1 250 ? -11.297 54.252 8.603 1.00 40.93 ? 250 ASN A CA 1 ATOM 1996 C C . ASN A 1 250 ? -9.923 53.588 8.609 1.00 39.06 ? 250 ASN A C 1 ATOM 1997 O O . ASN A 1 250 ? -9.781 52.413 8.264 1.00 37.51 ? 250 ASN A O 1 ATOM 1998 C CB . ASN A 1 250 ? -12.135 53.692 9.759 1.00 43.17 ? 250 ASN A CB 1 ATOM 1999 C CG . ASN A 1 250 ? -11.398 53.724 11.084 1.00 47.02 ? 250 ASN A CG 1 ATOM 2000 O OD1 . ASN A 1 250 ? -11.078 54.795 11.602 1.00 49.44 ? 250 ASN A OD1 1 ATOM 2001 N ND2 . ASN A 1 250 ? -11.117 52.548 11.637 1.00 47.68 ? 250 ASN A ND2 1 ATOM 2002 N N . PHE A 1 251 ? -8.910 54.360 8.990 1.00 36.79 ? 251 PHE A N 1 ATOM 2003 C CA . PHE A 1 251 ? -7.558 53.837 9.102 1.00 34.28 ? 251 PHE A CA 1 ATOM 2004 C C . PHE A 1 251 ? -7.220 53.894 10.578 1.00 33.14 ? 251 PHE A C 1 ATOM 2005 O O . PHE A 1 251 ? -7.202 54.970 11.174 1.00 33.07 ? 251 PHE A O 1 ATOM 2006 C CB . PHE A 1 251 ? -6.544 54.681 8.339 1.00 31.92 ? 251 PHE A CB 1 ATOM 2007 C CG . PHE A 1 251 ? -5.124 54.267 8.595 1.00 31.36 ? 251 PHE A CG 1 ATOM 2008 C CD1 . PHE A 1 251 ? -4.663 53.023 8.171 1.00 31.28 ? 251 PHE A CD1 1 ATOM 2009 C CD2 . PHE A 1 251 ? -4.257 55.098 9.302 1.00 30.91 ? 251 PHE A CD2 1 ATOM 2010 C CE1 . PHE A 1 251 ? -3.360 52.607 8.447 1.00 30.25 ? 251 PHE A CE1 1 ATOM 2011 C CE2 . PHE A 1 251 ? -2.954 54.695 9.585 1.00 31.23 ? 251 PHE A CE2 1 ATOM 2012 C CZ . PHE A 1 251 ? -2.504 53.445 9.156 1.00 31.68 ? 251 PHE A CZ 1 ATOM 2013 N N . LEU A 1 252 ? -6.954 52.736 11.164 1.00 32.71 ? 252 LEU A N 1 ATOM 2014 C CA . LEU A 1 252 ? -6.635 52.658 12.580 1.00 31.93 ? 252 LEU A CA 1 ATOM 2015 C C . LEU A 1 252 ? -5.176 52.258 12.786 1.00 30.93 ? 252 LEU A C 1 ATOM 2016 O O . LEU A 1 252 ? -4.792 51.122 12.506 1.00 30.40 ? 252 LEU A O 1 ATOM 2017 C CB . LEU A 1 252 ? -7.558 51.640 13.252 1.00 33.31 ? 252 LEU A CB 1 ATOM 2018 C CG . LEU A 1 252 ? -7.408 51.440 14.762 1.00 39.23 ? 252 LEU A CG 1 ATOM 2019 C CD1 . LEU A 1 252 ? -7.825 52.717 15.496 1.00 38.98 ? 252 LEU A CD1 1 ATOM 2020 C CD2 . LEU A 1 252 ? -8.264 50.257 15.209 1.00 37.45 ? 252 LEU A CD2 1 ATOM 2021 N N . PRO A 1 253 ? -4.339 53.193 13.271 1.00 29.51 ? 253 PRO A N 1 ATOM 2022 C CA . PRO A 1 253 ? -2.926 52.875 13.494 1.00 29.10 ? 253 PRO A CA 1 ATOM 2023 C C . PRO A 1 253 ? -2.764 51.775 14.539 1.00 29.52 ? 253 PRO A C 1 ATOM 2024 O O . PRO A 1 253 ? -3.395 51.798 15.592 1.00 30.37 ? 253 PRO A O 1 ATOM 2025 C CB . PRO A 1 253 ? -2.335 54.210 13.942 1.00 29.07 ? 253 PRO A CB 1 ATOM 2026 C CG . PRO A 1 253 ? -3.495 54.870 14.635 1.00 30.98 ? 253 PRO A CG 1 ATOM 2027 C CD . PRO A 1 253 ? -4.642 54.571 13.694 1.00 28.83 ? 253 PRO A CD 1 ATOM 2028 N N . GLN A 1 254 ? -1.912 50.810 14.229 1.00 29.44 ? 254 GLN A N 1 ATOM 2029 C CA . GLN A 1 254 ? -1.655 49.681 15.105 1.00 30.26 ? 254 GLN A CA 1 ATOM 2030 C C . GLN A 1 254 ? -1.185 50.089 16.509 1.00 30.67 ? 254 GLN A C 1 ATOM 2031 O O . GLN A 1 254 ? -1.537 49.443 17.496 1.00 31.28 ? 254 GLN A O 1 ATOM 2032 C CB . GLN A 1 254 ? -0.607 48.790 14.454 1.00 33.44 ? 254 GLN A CB 1 ATOM 2033 C CG . GLN A 1 254 ? -0.635 47.350 14.888 1.00 37.03 ? 254 GLN A CG 1 ATOM 2034 C CD . GLN A 1 254 ? 0.524 46.569 14.302 1.00 39.80 ? 254 GLN A CD 1 ATOM 2035 O OE1 . GLN A 1 254 ? 0.466 45.346 14.189 1.00 43.10 ? 254 GLN A OE1 1 ATOM 2036 N NE2 . GLN A 1 254 ? 1.592 47.274 13.936 1.00 40.04 ? 254 GLN A NE2 1 ATOM 2037 N N . ASN A 1 255 ? -0.383 51.146 16.601 1.00 29.02 ? 255 ASN A N 1 ATOM 2038 C CA . ASN A 1 255 ? 0.114 51.596 17.898 1.00 29.83 ? 255 ASN A CA 1 ATOM 2039 C C . ASN A 1 255 ? -0.774 52.692 18.490 1.00 30.50 ? 255 ASN A C 1 ATOM 2040 O O . ASN A 1 255 ? -0.408 53.332 19.475 1.00 30.74 ? 255 ASN A O 1 ATOM 2041 C CB . ASN A 1 255 ? 1.561 52.106 17.785 1.00 27.70 ? 255 ASN A CB 1 ATOM 2042 C CG . ASN A 1 255 ? 1.689 53.325 16.886 1.00 28.58 ? 255 ASN A CG 1 ATOM 2043 O OD1 . ASN A 1 255 ? 0.743 54.101 16.725 1.00 27.25 ? 255 ASN A OD1 1 ATOM 2044 N ND2 . ASN A 1 255 ? 2.870 53.510 16.312 1.00 28.22 ? 255 ASN A ND2 1 ATOM 2045 N N . GLY A 1 256 ? -1.936 52.902 17.878 1.00 30.14 ? 256 GLY A N 1 ATOM 2046 C CA . GLY A 1 256 ? -2.872 53.908 18.352 1.00 28.91 ? 256 GLY A CA 1 ATOM 2047 C C . GLY A 1 256 ? -2.395 55.352 18.353 1.00 29.87 ? 256 GLY A C 1 ATOM 2048 O O . GLY A 1 256 ? -3.086 56.228 18.869 1.00 30.08 ? 256 GLY A O 1 ATOM 2049 N N . LEU A 1 257 ? -1.233 55.624 17.772 1.00 29.16 ? 257 LEU A N 1 ATOM 2050 C CA . LEU A 1 257 ? -0.727 56.987 17.766 1.00 29.49 ? 257 LEU A CA 1 ATOM 2051 C C . LEU A 1 257 ? -1.050 57.769 16.505 1.00 30.31 ? 257 LEU A C 1 ATOM 2052 O O . LEU A 1 257 ? -1.271 57.198 15.439 1.00 30.86 ? 257 LEU A O 1 ATOM 2053 C CB . LEU A 1 257 ? 0.794 56.995 17.947 1.00 28.95 ? 257 LEU A CB 1 ATOM 2054 C CG . LEU A 1 257 ? 1.417 56.226 19.113 1.00 29.76 ? 257 LEU A CG 1 ATOM 2055 C CD1 . LEU A 1 257 ? 2.925 56.438 19.102 1.00 27.51 ? 257 LEU A CD1 1 ATOM 2056 C CD2 . LEU A 1 257 ? 0.819 56.699 20.424 1.00 28.16 ? 257 LEU A CD2 1 ATOM 2057 N N . SER A 1 258 ? -1.089 59.089 16.648 1.00 30.69 ? 258 SER A N 1 ATOM 2058 C CA . SER A 1 258 ? -1.293 59.978 15.516 1.00 31.05 ? 258 SER A CA 1 ATOM 2059 C C . SER A 1 258 ? 0.144 60.399 15.248 1.00 31.16 ? 258 SER A C 1 ATOM 2060 O O . SER A 1 258 ? 0.923 60.548 16.190 1.00 32.08 ? 258 SER A O 1 ATOM 2061 C CB . SER A 1 258 ? -2.115 61.207 15.908 1.00 32.03 ? 258 SER A CB 1 ATOM 2062 O OG . SER A 1 258 ? -3.457 60.857 16.191 1.00 38.22 ? 258 SER A OG 1 ATOM 2063 N N . LEU A 1 259 ? 0.512 60.571 13.987 1.00 29.81 ? 259 LEU A N 1 ATOM 2064 C CA . LEU A 1 259 ? 1.876 60.971 13.678 1.00 28.66 ? 259 LEU A CA 1 ATOM 2065 C C . LEU A 1 259 ? 2.203 62.292 14.363 1.00 29.19 ? 259 LEU A C 1 ATOM 2066 O O . LEU A 1 259 ? 1.343 63.170 14.475 1.00 31.10 ? 259 LEU A O 1 ATOM 2067 C CB . LEU A 1 259 ? 2.056 61.094 12.162 1.00 26.75 ? 259 LEU A CB 1 ATOM 2068 C CG . LEU A 1 259 ? 1.922 59.756 11.433 1.00 24.80 ? 259 LEU A CG 1 ATOM 2069 C CD1 . LEU A 1 259 ? 1.873 59.978 9.933 1.00 25.17 ? 259 LEU A CD1 1 ATOM 2070 C CD2 . LEU A 1 259 ? 3.097 58.857 11.812 1.00 24.39 ? 259 LEU A CD2 1 ATOM 2071 N N . THR A 1 260 ? 3.437 62.419 14.843 1.00 27.60 ? 260 THR A N 1 ATOM 2072 C CA . THR A 1 260 ? 3.880 63.642 15.506 1.00 28.03 ? 260 THR A CA 1 ATOM 2073 C C . THR A 1 260 ? 5.215 64.122 14.959 1.00 27.93 ? 260 THR A C 1 ATOM 2074 O O . THR A 1 260 ? 5.662 65.220 15.281 1.00 29.05 ? 260 THR A O 1 ATOM 2075 C CB . THR A 1 260 ? 4.035 63.455 17.036 1.00 26.74 ? 260 THR A CB 1 ATOM 2076 O OG1 . THR A 1 260 ? 4.823 62.290 17.306 1.00 26.85 ? 260 THR A OG1 1 ATOM 2077 C CG2 . THR A 1 260 ? 2.680 63.319 17.697 1.00 26.82 ? 260 THR A CG2 1 ATOM 2078 N N . GLY A 1 261 ? 5.849 63.301 14.128 1.00 27.70 ? 261 GLY A N 1 ATOM 2079 C CA . GLY A 1 261 ? 7.136 63.676 13.580 1.00 25.89 ? 261 GLY A CA 1 ATOM 2080 C C . GLY A 1 261 ? 8.189 63.656 14.670 1.00 25.86 ? 261 GLY A C 1 ATOM 2081 O O . GLY A 1 261 ? 9.132 64.443 14.649 1.00 26.33 ? 261 GLY A O 1 ATOM 2082 N N . SER A 1 262 ? 8.021 62.757 15.633 1.00 24.37 ? 262 SER A N 1 ATOM 2083 C CA . SER A 1 262 ? 8.968 62.632 16.736 1.00 26.51 ? 262 SER A CA 1 ATOM 2084 C C . SER A 1 262 ? 9.654 61.265 16.715 1.00 27.76 ? 262 SER A C 1 ATOM 2085 O O . SER A 1 262 ? 9.342 60.408 15.879 1.00 27.35 ? 262 SER A O 1 ATOM 2086 C CB . SER A 1 262 ? 8.249 62.804 18.076 1.00 25.67 ? 262 SER A CB 1 ATOM 2087 O OG . SER A 1 262 ? 7.343 61.737 18.299 1.00 25.11 ? 262 SER A OG 1 ATOM 2088 N N . THR A 1 263 ? 10.577 61.062 17.650 1.00 27.44 ? 263 THR A N 1 ATOM 2089 C CA . THR A 1 263 ? 11.303 59.801 17.745 1.00 28.27 ? 263 THR A CA 1 ATOM 2090 C C . THR A 1 263 ? 10.339 58.656 18.056 1.00 28.46 ? 263 THR A C 1 ATOM 2091 O O . THR A 1 263 ? 10.732 57.493 18.152 1.00 28.04 ? 263 THR A O 1 ATOM 2092 C CB . THR A 1 263 ? 12.395 59.885 18.828 1.00 28.49 ? 263 THR A CB 1 ATOM 2093 O OG1 . THR A 1 263 ? 11.820 60.350 20.056 1.00 26.52 ? 263 THR A OG1 1 ATOM 2094 C CG2 . THR A 1 263 ? 13.497 60.848 18.391 1.00 26.03 ? 263 THR A CG2 1 ATOM 2095 N N . LEU A 1 264 ? 9.068 59.006 18.199 1.00 29.25 ? 264 LEU A N 1 ATOM 2096 C CA . LEU A 1 264 ? 8.002 58.049 18.474 1.00 29.36 ? 264 LEU A CA 1 ATOM 2097 C C . LEU A 1 264 ? 7.535 57.381 17.166 1.00 30.28 ? 264 LEU A C 1 ATOM 2098 O O . LEU A 1 264 ? 7.010 56.265 17.184 1.00 30.88 ? 264 LEU A O 1 ATOM 2099 C CB . LEU A 1 264 ? 6.821 58.793 19.104 1.00 29.61 ? 264 LEU A CB 1 ATOM 2100 C CG . LEU A 1 264 ? 6.324 58.545 20.529 1.00 31.52 ? 264 LEU A CG 1 ATOM 2101 C CD1 . LEU A 1 264 ? 7.453 58.176 21.467 1.00 29.82 ? 264 LEU A CD1 1 ATOM 2102 C CD2 . LEU A 1 264 ? 5.618 59.814 20.994 1.00 28.88 ? 264 LEU A CD2 1 ATOM 2103 N N . ASP A 1 265 ? 7.727 58.067 16.038 1.00 26.98 ? 265 ASP A N 1 ATOM 2104 C CA . ASP A 1 265 ? 7.283 57.548 14.746 1.00 26.03 ? 265 ASP A CA 1 ATOM 2105 C C . ASP A 1 265 ? 8.375 56.928 13.889 1.00 23.97 ? 265 ASP A C 1 ATOM 2106 O O . ASP A 1 265 ? 9.560 57.197 14.072 1.00 23.92 ? 265 ASP A O 1 ATOM 2107 C CB . ASP A 1 265 ? 6.604 58.654 13.930 1.00 26.91 ? 265 ASP A CB 1 ATOM 2108 C CG . ASP A 1 265 ? 5.525 59.375 14.707 1.00 27.12 ? 265 ASP A CG 1 ATOM 2109 O OD1 . ASP A 1 265 ? 4.764 58.704 15.440 1.00 27.31 ? 265 ASP A OD1 1 ATOM 2110 O OD2 . ASP A 1 265 ? 5.435 60.614 14.573 1.00 26.09 ? 265 ASP A OD2 1 ATOM 2111 N N . LEU A 1 266 ? 7.952 56.106 12.937 1.00 21.62 ? 266 LEU A N 1 ATOM 2112 C CA . LEU A 1 266 ? 8.871 55.433 12.028 1.00 20.98 ? 266 LEU A CA 1 ATOM 2113 C C . LEU A 1 266 ? 9.086 56.219 10.742 1.00 21.12 ? 266 LEU A C 1 ATOM 2114 O O . LEU A 1 266 ? 8.247 57.028 10.335 1.00 20.31 ? 266 LEU A O 1 ATOM 2115 C CB . LEU A 1 266 ? 8.333 54.047 11.663 1.00 19.16 ? 266 LEU A CB 1 ATOM 2116 C CG . LEU A 1 266 ? 8.293 52.988 12.768 1.00 19.44 ? 266 LEU A CG 1 ATOM 2117 C CD1 . LEU A 1 266 ? 7.428 51.814 12.344 1.00 15.13 ? 266 LEU A CD1 1 ATOM 2118 C CD2 . LEU A 1 266 ? 9.707 52.535 13.068 1.00 17.88 ? 266 LEU A CD2 1 ATOM 2119 N N . ARG A 1 267 ? 10.229 55.971 10.114 1.00 20.95 ? 267 ARG A N 1 ATOM 2120 C CA . ARG A 1 267 ? 10.575 56.591 8.845 1.00 21.01 ? 267 ARG A CA 1 ATOM 2121 C C . ARG A 1 267 ? 11.070 55.451 7.968 1.00 21.82 ? 267 ARG A C 1 ATOM 2122 O O . ARG A 1 267 ? 11.438 54.391 8.476 1.00 21.68 ? 267 ARG A O 1 ATOM 2123 C CB . ARG A 1 267 ? 11.723 57.590 8.992 1.00 21.29 ? 267 ARG A CB 1 ATOM 2124 C CG . ARG A 1 267 ? 11.481 58.776 9.899 1.00 23.14 ? 267 ARG A CG 1 ATOM 2125 C CD . ARG A 1 267 ? 12.613 59.780 9.703 1.00 23.76 ? 267 ARG A CD 1 ATOM 2126 N NE . ARG A 1 267 ? 12.799 60.659 10.850 1.00 24.69 ? 267 ARG A NE 1 ATOM 2127 C CZ . ARG A 1 267 ? 13.790 61.540 10.956 1.00 24.57 ? 267 ARG A CZ 1 ATOM 2128 N NH1 . ARG A 1 267 ? 14.674 61.657 9.976 1.00 20.96 ? 267 ARG A NH1 1 ATOM 2129 N NH2 . ARG A 1 267 ? 13.912 62.283 12.051 1.00 23.25 ? 267 ARG A NH2 1 ATOM 2130 N N . TYR A 1 268 ? 11.071 55.659 6.658 1.00 20.45 ? 268 TYR A N 1 ATOM 2131 C CA . TYR A 1 268 ? 11.592 54.647 5.758 1.00 19.26 ? 268 TYR A CA 1 ATOM 2132 C C . TYR A 1 268 ? 13.109 54.714 5.905 1.00 19.29 ? 268 TYR A C 1 ATOM 2133 O O . TYR A 1 268 ? 13.793 53.705 6.074 1.00 19.64 ? 268 TYR A O 1 ATOM 2134 C CB . TYR A 1 268 ? 11.283 54.985 4.298 1.00 18.55 ? 268 TYR A CB 1 ATOM 2135 C CG . TYR A 1 268 ? 9.877 54.745 3.820 1.00 19.30 ? 268 TYR A CG 1 ATOM 2136 C CD1 . TYR A 1 268 ? 9.255 53.509 3.995 1.00 19.29 ? 268 TYR A CD1 1 ATOM 2137 C CD2 . TYR A 1 268 ? 9.205 55.723 3.092 1.00 19.43 ? 268 TYR A CD2 1 ATOM 2138 C CE1 . TYR A 1 268 ? 7.997 53.254 3.447 1.00 21.06 ? 268 TYR A CE1 1 ATOM 2139 C CE2 . TYR A 1 268 ? 7.956 55.482 2.540 1.00 20.21 ? 268 TYR A CE2 1 ATOM 2140 C CZ . TYR A 1 268 ? 7.354 54.249 2.716 1.00 21.36 ? 268 TYR A CZ 1 ATOM 2141 O OH . TYR A 1 268 ? 6.118 54.015 2.148 1.00 19.35 ? 268 TYR A OH 1 ATOM 2142 N N . ASP A 1 269 ? 13.613 55.943 5.837 1.00 19.36 ? 269 ASP A N 1 ATOM 2143 C CA . ASP A 1 269 ? 15.039 56.223 5.876 1.00 18.77 ? 269 ASP A CA 1 ATOM 2144 C C . ASP A 1 269 ? 15.288 57.398 6.816 1.00 19.33 ? 269 ASP A C 1 ATOM 2145 O O . ASP A 1 269 ? 14.529 58.370 6.817 1.00 20.18 ? 269 ASP A O 1 ATOM 2146 C CB . ASP A 1 269 ? 15.482 56.558 4.447 1.00 17.69 ? 269 ASP A CB 1 ATOM 2147 C CG . ASP A 1 269 ? 16.973 56.606 4.289 1.00 18.19 ? 269 ASP A CG 1 ATOM 2148 O OD1 . ASP A 1 269 ? 17.502 55.764 3.542 1.00 19.02 ? 269 ASP A OD1 1 ATOM 2149 O OD2 . ASP A 1 269 ? 17.616 57.488 4.898 1.00 22.39 ? 269 ASP A OD2 1 ATOM 2150 N N . TYR A 1 270 ? 16.356 57.318 7.603 1.00 19.42 ? 270 TYR A N 1 ATOM 2151 C CA . TYR A 1 270 ? 16.665 58.366 8.570 1.00 19.96 ? 270 TYR A CA 1 ATOM 2152 C C . TYR A 1 270 ? 17.717 59.381 8.129 1.00 20.55 ? 270 TYR A C 1 ATOM 2153 O O . TYR A 1 270 ? 18.255 60.121 8.956 1.00 21.04 ? 270 TYR A O 1 ATOM 2154 C CB . TYR A 1 270 ? 17.062 57.721 9.902 1.00 20.57 ? 270 TYR A CB 1 ATOM 2155 C CG . TYR A 1 270 ? 15.932 56.918 10.502 1.00 21.23 ? 270 TYR A CG 1 ATOM 2156 C CD1 . TYR A 1 270 ? 15.041 57.494 11.415 1.00 21.99 ? 270 TYR A CD1 1 ATOM 2157 C CD2 . TYR A 1 270 ? 15.692 55.606 10.085 1.00 21.35 ? 270 TYR A CD2 1 ATOM 2158 C CE1 . TYR A 1 270 ? 13.927 56.778 11.893 1.00 20.84 ? 270 TYR A CE1 1 ATOM 2159 C CE2 . TYR A 1 270 ? 14.588 54.885 10.550 1.00 20.74 ? 270 TYR A CE2 1 ATOM 2160 C CZ . TYR A 1 270 ? 13.709 55.474 11.449 1.00 22.17 ? 270 TYR A CZ 1 ATOM 2161 O OH . TYR A 1 270 ? 12.606 54.763 11.877 1.00 21.35 ? 270 TYR A OH 1 ATOM 2162 N N . GLY A 1 271 ? 17.988 59.423 6.825 1.00 19.10 ? 271 GLY A N 1 ATOM 2163 C CA . GLY A 1 271 ? 18.951 60.367 6.283 1.00 17.44 ? 271 GLY A CA 1 ATOM 2164 C C . GLY A 1 271 ? 18.255 61.292 5.296 1.00 18.84 ? 271 GLY A C 1 ATOM 2165 O O . GLY A 1 271 ? 17.140 61.751 5.558 1.00 16.03 ? 271 GLY A O 1 ATOM 2166 N N . GLN A 1 272 ? 18.914 61.575 4.172 1.00 19.21 ? 272 GLN A N 1 ATOM 2167 C CA . GLN A 1 272 ? 18.349 62.429 3.124 1.00 20.48 ? 272 GLN A CA 1 ATOM 2168 C C . GLN A 1 272 ? 17.456 61.539 2.273 1.00 21.48 ? 272 GLN A C 1 ATOM 2169 O O . GLN A 1 272 ? 17.940 60.767 1.448 1.00 22.97 ? 272 GLN A O 1 ATOM 2170 C CB . GLN A 1 272 ? 19.466 63.019 2.262 1.00 20.93 ? 272 GLN A CB 1 ATOM 2171 C CG . GLN A 1 272 ? 20.257 64.121 2.938 1.00 21.05 ? 272 GLN A CG 1 ATOM 2172 C CD . GLN A 1 272 ? 19.382 65.309 3.304 1.00 24.51 ? 272 GLN A CD 1 ATOM 2173 O OE1 . GLN A 1 272 ? 18.483 65.691 2.549 1.00 24.91 ? 272 GLN A OE1 1 ATOM 2174 N NE2 . GLN A 1 272 ? 19.651 65.909 4.456 1.00 22.34 ? 272 GLN A NE2 1 ATOM 2175 N N . PHE A 1 273 ? 16.149 61.672 2.455 1.00 21.93 ? 273 PHE A N 1 ATOM 2176 C CA . PHE A 1 273 ? 15.197 60.813 1.763 1.00 21.77 ? 273 PHE A CA 1 ATOM 2177 C C . PHE A 1 273 ? 13.853 61.528 1.850 1.00 22.42 ? 273 PHE A C 1 ATOM 2178 O O . PHE A 1 273 ? 13.348 61.730 2.949 1.00 24.42 ? 273 PHE A O 1 ATOM 2179 C CB . PHE A 1 273 ? 15.144 59.502 2.543 1.00 21.08 ? 273 PHE A CB 1 ATOM 2180 C CG . PHE A 1 273 ? 14.577 58.339 1.793 1.00 20.88 ? 273 PHE A CG 1 ATOM 2181 C CD1 . PHE A 1 273 ? 15.408 57.517 1.030 1.00 19.06 ? 273 PHE A CD1 1 ATOM 2182 C CD2 . PHE A 1 273 ? 13.234 57.990 1.941 1.00 18.80 ? 273 PHE A CD2 1 ATOM 2183 C CE1 . PHE A 1 273 ? 14.912 56.353 0.435 1.00 18.99 ? 273 PHE A CE1 1 ATOM 2184 C CE2 . PHE A 1 273 ? 12.725 56.829 1.351 1.00 19.59 ? 273 PHE A CE2 1 ATOM 2185 C CZ . PHE A 1 273 ? 13.568 56.006 0.598 1.00 18.47 ? 273 PHE A CZ 1 ATOM 2186 N N . TYR A 1 274 ? 13.264 61.907 0.718 1.00 22.06 ? 274 TYR A N 1 ATOM 2187 C CA . TYR A 1 274 ? 11.985 62.615 0.768 1.00 22.18 ? 274 TYR A CA 1 ATOM 2188 C C . TYR A 1 274 ? 11.068 62.392 -0.443 1.00 21.30 ? 274 TYR A C 1 ATOM 2189 O O . TYR A 1 274 ? 11.520 62.011 -1.528 1.00 20.47 ? 274 TYR A O 1 ATOM 2190 C CB . TYR A 1 274 ? 12.227 64.128 0.948 1.00 19.71 ? 274 TYR A CB 1 ATOM 2191 C CG . TYR A 1 274 ? 11.010 64.877 1.451 1.00 19.42 ? 274 TYR A CG 1 ATOM 2192 C CD1 . TYR A 1 274 ? 10.555 64.697 2.761 1.00 19.67 ? 274 TYR A CD1 1 ATOM 2193 C CD2 . TYR A 1 274 ? 10.273 65.716 0.605 1.00 18.43 ? 274 TYR A CD2 1 ATOM 2194 C CE1 . TYR A 1 274 ? 9.396 65.324 3.222 1.00 17.53 ? 274 TYR A CE1 1 ATOM 2195 C CE2 . TYR A 1 274 ? 9.105 66.352 1.053 1.00 16.50 ? 274 TYR A CE2 1 ATOM 2196 C CZ . TYR A 1 274 ? 8.673 66.146 2.366 1.00 21.21 ? 274 TYR A CZ 1 ATOM 2197 O OH . TYR A 1 274 ? 7.514 66.736 2.828 1.00 19.91 ? 274 TYR A OH 1 ATOM 2198 N N . ALA A 1 275 ? 9.775 62.636 -0.241 1.00 19.49 ? 275 ALA A N 1 ATOM 2199 C CA . ALA A 1 275 ? 8.786 62.485 -1.303 1.00 20.68 ? 275 ALA A CA 1 ATOM 2200 C C . ALA A 1 275 ? 8.774 61.068 -1.875 1.00 19.96 ? 275 ALA A C 1 ATOM 2201 O O . ALA A 1 275 ? 8.485 60.865 -3.055 1.00 21.34 ? 275 ALA A O 1 ATOM 2202 C CB . ALA A 1 275 ? 9.062 63.500 -2.418 1.00 17.46 ? 275 ALA A CB 1 ATOM 2203 N N . SER A 1 276 ? 9.085 60.090 -1.034 1.00 19.72 ? 276 SER A N 1 ATOM 2204 C CA . SER A 1 276 ? 9.115 58.706 -1.475 1.00 19.79 ? 276 SER A CA 1 ATOM 2205 C C . SER A 1 276 ? 7.732 58.279 -1.966 1.00 21.41 ? 276 SER A C 1 ATOM 2206 O O . SER A 1 276 ? 6.703 58.741 -1.458 1.00 20.03 ? 276 SER A O 1 ATOM 2207 C CB . SER A 1 276 ? 9.579 57.794 -0.332 1.00 18.56 ? 276 SER A CB 1 ATOM 2208 O OG . SER A 1 276 ? 8.695 57.861 0.778 1.00 21.68 ? 276 SER A OG 1 ATOM 2209 N N . LYS A 1 277 ? 7.726 57.406 -2.970 1.00 20.63 ? 277 LYS A N 1 ATOM 2210 C CA . LYS A 1 277 ? 6.499 56.889 -3.554 1.00 21.43 ? 277 LYS A CA 1 ATOM 2211 C C . LYS A 1 277 ? 6.734 55.453 -4.025 1.00 21.48 ? 277 LYS A C 1 ATOM 2212 O O . LYS A 1 277 ? 7.787 55.138 -4.586 1.00 20.61 ? 277 LYS A O 1 ATOM 2213 C CB . LYS A 1 277 ? 6.067 57.749 -4.740 1.00 21.87 ? 277 LYS A CB 1 ATOM 2214 C CG . LYS A 1 277 ? 4.773 57.274 -5.377 1.00 25.34 ? 277 LYS A CG 1 ATOM 2215 C CD . LYS A 1 277 ? 4.450 58.047 -6.633 1.00 25.36 ? 277 LYS A CD 1 ATOM 2216 C CE . LYS A 1 277 ? 4.374 59.527 -6.354 1.00 28.47 ? 277 LYS A CE 1 ATOM 2217 N NZ . LYS A 1 277 ? 3.285 59.845 -5.408 1.00 25.77 ? 277 LYS A NZ 1 ATOM 2218 N N . SER A 1 278 ? 5.752 54.588 -3.800 1.00 19.86 ? 278 SER A N 1 ATOM 2219 C CA . SER A 1 278 ? 5.877 53.189 -4.191 1.00 19.44 ? 278 SER A CA 1 ATOM 2220 C C . SER A 1 278 ? 4.863 52.789 -5.254 1.00 18.93 ? 278 SER A C 1 ATOM 2221 O O . SER A 1 278 ? 3.885 53.492 -5.491 1.00 18.37 ? 278 SER A O 1 ATOM 2222 C CB . SER A 1 278 ? 5.677 52.289 -2.972 1.00 19.18 ? 278 SER A CB 1 ATOM 2223 O OG . SER A 1 278 ? 4.333 52.360 -2.512 1.00 18.37 ? 278 SER A OG 1 ATOM 2224 N N . PHE A 1 279 ? 5.113 51.651 -5.893 1.00 18.59 ? 279 PHE A N 1 ATOM 2225 C CA . PHE A 1 279 ? 4.206 51.117 -6.897 1.00 19.32 ? 279 PHE A CA 1 ATOM 2226 C C . PHE A 1 279 ? 4.318 49.603 -6.831 1.00 20.56 ? 279 PHE A C 1 ATOM 2227 O O . PHE A 1 279 ? 5.314 49.070 -6.338 1.00 20.74 ? 279 PHE A O 1 ATOM 2228 C CB . PHE A 1 279 ? 4.564 51.631 -8.299 1.00 19.35 ? 279 PHE A CB 1 ATOM 2229 C CG . PHE A 1 279 ? 5.799 51.010 -8.894 1.00 20.46 ? 279 PHE A CG 1 ATOM 2230 C CD1 . PHE A 1 279 ? 5.701 49.913 -9.748 1.00 20.71 ? 279 PHE A CD1 1 ATOM 2231 C CD2 . PHE A 1 279 ? 7.058 51.542 -8.630 1.00 19.37 ? 279 PHE A CD2 1 ATOM 2232 C CE1 . PHE A 1 279 ? 6.840 49.360 -10.337 1.00 20.93 ? 279 PHE A CE1 1 ATOM 2233 C CE2 . PHE A 1 279 ? 8.201 50.999 -9.209 1.00 20.18 ? 279 PHE A CE2 1 ATOM 2234 C CZ . PHE A 1 279 ? 8.094 49.905 -10.066 1.00 20.74 ? 279 PHE A CZ 1 ATOM 2235 N N . PHE A 1 280 ? 3.293 48.905 -7.305 1.00 20.86 ? 280 PHE A N 1 ATOM 2236 C CA . PHE A 1 280 ? 3.318 47.456 -7.279 1.00 20.24 ? 280 PHE A CA 1 ATOM 2237 C C . PHE A 1 280 ? 3.816 46.893 -8.601 1.00 22.05 ? 280 PHE A C 1 ATOM 2238 O O . PHE A 1 280 ? 3.387 47.318 -9.675 1.00 23.42 ? 280 PHE A O 1 ATOM 2239 C CB . PHE A 1 280 ? 1.927 46.901 -6.972 1.00 20.69 ? 280 PHE A CB 1 ATOM 2240 C CG . PHE A 1 280 ? 1.862 45.400 -6.990 1.00 21.13 ? 280 PHE A CG 1 ATOM 2241 C CD1 . PHE A 1 280 ? 2.585 44.649 -6.066 1.00 21.91 ? 280 PHE A CD1 1 ATOM 2242 C CD2 . PHE A 1 280 ? 1.097 44.734 -7.946 1.00 21.34 ? 280 PHE A CD2 1 ATOM 2243 C CE1 . PHE A 1 280 ? 2.550 43.250 -6.095 1.00 21.96 ? 280 PHE A CE1 1 ATOM 2244 C CE2 . PHE A 1 280 ? 1.053 43.339 -7.984 1.00 22.07 ? 280 PHE A CE2 1 ATOM 2245 C CZ . PHE A 1 280 ? 1.781 42.596 -7.059 1.00 20.95 ? 280 PHE A CZ 1 ATOM 2246 N N . ASP A 1 281 ? 4.730 45.935 -8.501 1.00 23.14 ? 281 ASP A N 1 ATOM 2247 C CA . ASP A 1 281 ? 5.331 45.261 -9.647 1.00 24.65 ? 281 ASP A CA 1 ATOM 2248 C C . ASP A 1 281 ? 4.710 43.863 -9.674 1.00 26.94 ? 281 ASP A C 1 ATOM 2249 O O . ASP A 1 281 ? 5.144 42.979 -8.939 1.00 25.26 ? 281 ASP A O 1 ATOM 2250 C CB . ASP A 1 281 ? 6.843 45.171 -9.413 1.00 25.46 ? 281 ASP A CB 1 ATOM 2251 C CG . ASP A 1 281 ? 7.570 44.385 -10.483 1.00 26.35 ? 281 ASP A CG 1 ATOM 2252 O OD1 . ASP A 1 281 ? 6.941 43.541 -11.167 1.00 24.50 ? 281 ASP A OD1 1 ATOM 2253 O OD2 . ASP A 1 281 ? 8.795 44.608 -10.617 1.00 25.67 ? 281 ASP A OD2 1 ATOM 2254 N N . ASP A 1 282 ? 3.698 43.656 -10.514 1.00 30.38 ? 282 ASP A N 1 ATOM 2255 C CA . ASP A 1 282 ? 3.037 42.354 -10.563 1.00 34.42 ? 282 ASP A CA 1 ATOM 2256 C C . ASP A 1 282 ? 3.836 41.280 -11.290 1.00 33.33 ? 282 ASP A C 1 ATOM 2257 O O . ASP A 1 282 ? 3.487 40.103 -11.230 1.00 34.69 ? 282 ASP A O 1 ATOM 2258 C CB . ASP A 1 282 ? 1.644 42.475 -11.193 1.00 39.34 ? 282 ASP A CB 1 ATOM 2259 C CG . ASP A 1 282 ? 1.684 42.474 -12.705 1.00 46.11 ? 282 ASP A CG 1 ATOM 2260 O OD1 . ASP A 1 282 ? 2.355 43.353 -13.293 1.00 49.49 ? 282 ASP A OD1 1 ATOM 2261 O OD2 . ASP A 1 282 ? 1.039 41.587 -13.308 1.00 50.35 ? 282 ASP A OD2 1 ATOM 2262 N N . ALA A 1 283 ? 4.906 41.674 -11.972 1.00 31.82 ? 283 ALA A N 1 ATOM 2263 C CA . ALA A 1 283 ? 5.731 40.701 -12.677 1.00 31.14 ? 283 ALA A CA 1 ATOM 2264 C C . ALA A 1 283 ? 6.577 39.947 -11.657 1.00 31.84 ? 283 ALA A C 1 ATOM 2265 O O . ALA A 1 283 ? 6.815 38.747 -11.798 1.00 31.68 ? 283 ALA A O 1 ATOM 2266 C CB . ALA A 1 283 ? 6.628 41.396 -13.692 1.00 28.72 ? 283 ALA A CB 1 ATOM 2267 N N . LYS A 1 284 ? 7.025 40.655 -10.624 1.00 30.90 ? 284 LYS A N 1 ATOM 2268 C CA . LYS A 1 284 ? 7.840 40.042 -9.583 1.00 30.00 ? 284 LYS A CA 1 ATOM 2269 C C . LYS A 1 284 ? 7.169 40.047 -8.209 1.00 30.18 ? 284 LYS A C 1 ATOM 2270 O O . LYS A 1 284 ? 7.811 39.763 -7.197 1.00 29.96 ? 284 LYS A O 1 ATOM 2271 C CB . LYS A 1 284 ? 9.199 40.740 -9.503 1.00 28.82 ? 284 LYS A CB 1 ATOM 2272 C CG . LYS A 1 284 ? 10.086 40.472 -10.706 1.00 29.59 ? 284 LYS A CG 1 ATOM 2273 C CD . LYS A 1 284 ? 11.543 40.723 -10.376 1.00 32.47 ? 284 LYS A CD 1 ATOM 2274 C CE . LYS A 1 284 ? 12.473 40.212 -11.477 1.00 33.33 ? 284 LYS A CE 1 ATOM 2275 N NZ . LYS A 1 284 ? 13.916 40.382 -11.111 1.00 30.83 ? 284 LYS A NZ 1 ATOM 2276 N N . ASN A 1 285 ? 5.877 40.359 -8.182 1.00 29.92 ? 285 ASN A N 1 ATOM 2277 C CA . ASN A 1 285 ? 5.114 40.407 -6.933 1.00 31.13 ? 285 ASN A CA 1 ATOM 2278 C C . ASN A 1 285 ? 5.854 41.107 -5.799 1.00 29.04 ? 285 ASN A C 1 ATOM 2279 O O . ASN A 1 285 ? 6.046 40.545 -4.718 1.00 29.49 ? 285 ASN A O 1 ATOM 2280 C CB . ASN A 1 285 ? 4.714 38.994 -6.509 1.00 33.76 ? 285 ASN A CB 1 ATOM 2281 C CG . ASN A 1 285 ? 3.682 38.390 -7.439 1.00 40.12 ? 285 ASN A CG 1 ATOM 2282 O OD1 . ASN A 1 285 ? 2.546 38.862 -7.509 1.00 41.81 ? 285 ASN A OD1 1 ATOM 2283 N ND2 . ASN A 1 285 ? 4.075 37.353 -8.177 1.00 42.79 ? 285 ASN A ND2 1 ATOM 2284 N N . ARG A 1 286 ? 6.258 42.345 -6.055 1.00 25.92 ? 286 ARG A N 1 ATOM 2285 C CA . ARG A 1 286 ? 6.977 43.135 -5.067 1.00 24.59 ? 286 ARG A CA 1 ATOM 2286 C C . ARG A 1 286 ? 6.522 44.585 -5.150 1.00 23.09 ? 286 ARG A C 1 ATOM 2287 O O . ARG A 1 286 ? 6.058 45.045 -6.200 1.00 21.97 ? 286 ARG A O 1 ATOM 2288 C CB . ARG A 1 286 ? 8.486 43.067 -5.337 1.00 22.82 ? 286 ARG A CB 1 ATOM 2289 C CG . ARG A 1 286 ? 8.859 43.622 -6.707 1.00 23.90 ? 286 ARG A CG 1 ATOM 2290 C CD . ARG A 1 286 ? 10.351 43.568 -7.006 1.00 19.82 ? 286 ARG A CD 1 ATOM 2291 N NE . ARG A 1 286 ? 10.585 43.989 -8.385 1.00 20.21 ? 286 ARG A NE 1 ATOM 2292 C CZ . ARG A 1 286 ? 11.759 43.948 -9.005 1.00 20.58 ? 286 ARG A CZ 1 ATOM 2293 N NH1 . ARG A 1 286 ? 12.836 43.502 -8.376 1.00 18.64 ? 286 ARG A NH1 1 ATOM 2294 N NH2 . ARG A 1 286 ? 11.849 44.344 -10.269 1.00 21.32 ? 286 ARG A NH2 1 ATOM 2295 N N . ARG A 1 287 ? 6.631 45.297 -4.036 1.00 20.77 ? 287 ARG A N 1 ATOM 2296 C CA . ARG A 1 287 ? 6.282 46.708 -4.020 1.00 19.45 ? 287 ARG A CA 1 ATOM 2297 C C . ARG A 1 287 ? 7.632 47.416 -4.059 1.00 19.59 ? 287 ARG A C 1 ATOM 2298 O O . ARG A 1 287 ? 8.521 47.122 -3.252 1.00 18.94 ? 287 ARG A O 1 ATOM 2299 C CB . ARG A 1 287 ? 5.509 47.075 -2.750 1.00 19.25 ? 287 ARG A CB 1 ATOM 2300 C CG . ARG A 1 287 ? 5.218 48.569 -2.614 1.00 18.85 ? 287 ARG A CG 1 ATOM 2301 C CD . ARG A 1 287 ? 4.091 48.817 -1.627 1.00 20.22 ? 287 ARG A CD 1 ATOM 2302 N NE . ARG A 1 287 ? 2.814 48.344 -2.156 1.00 19.72 ? 287 ARG A NE 1 ATOM 2303 C CZ . ARG A 1 287 ? 2.068 49.020 -3.025 1.00 20.39 ? 287 ARG A CZ 1 ATOM 2304 N NH1 . ARG A 1 287 ? 2.466 50.212 -3.460 1.00 19.04 ? 287 ARG A NH1 1 ATOM 2305 N NH2 . ARG A 1 287 ? 0.933 48.494 -3.475 1.00 18.58 ? 287 ARG A NH2 1 ATOM 2306 N N . VAL A 1 288 ? 7.793 48.320 -5.018 1.00 17.66 ? 288 VAL A N 1 ATOM 2307 C CA . VAL A 1 288 ? 9.041 49.044 -5.180 1.00 18.26 ? 288 VAL A CA 1 ATOM 2308 C C . VAL A 1 288 ? 8.914 50.485 -4.706 1.00 19.87 ? 288 VAL A C 1 ATOM 2309 O O . VAL A 1 288 ? 7.907 51.152 -4.962 1.00 21.68 ? 288 VAL A O 1 ATOM 2310 C CB . VAL A 1 288 ? 9.492 49.001 -6.650 1.00 17.76 ? 288 VAL A CB 1 ATOM 2311 C CG1 . VAL A 1 288 ? 10.781 49.789 -6.838 1.00 16.07 ? 288 VAL A CG1 1 ATOM 2312 C CG2 . VAL A 1 288 ? 9.692 47.555 -7.066 1.00 16.53 ? 288 VAL A CG2 1 ATOM 2313 N N . LEU A 1 289 ? 9.944 50.958 -4.012 1.00 19.89 ? 289 LEU A N 1 ATOM 2314 C CA . LEU A 1 289 ? 9.948 52.306 -3.466 1.00 20.93 ? 289 LEU A CA 1 ATOM 2315 C C . LEU A 1 289 ? 11.016 53.219 -4.066 1.00 21.91 ? 289 LEU A C 1 ATOM 2316 O O . LEU A 1 289 ? 12.197 52.862 -4.115 1.00 23.75 ? 289 LEU A O 1 ATOM 2317 C CB . LEU A 1 289 ? 10.145 52.237 -1.947 1.00 21.63 ? 289 LEU A CB 1 ATOM 2318 C CG . LEU A 1 289 ? 10.076 53.549 -1.161 1.00 23.82 ? 289 LEU A CG 1 ATOM 2319 C CD1 . LEU A 1 289 ? 8.643 54.073 -1.192 1.00 21.02 ? 289 LEU A CD1 1 ATOM 2320 C CD2 . LEU A 1 289 ? 10.537 53.321 0.280 1.00 21.12 ? 289 LEU A CD2 1 ATOM 2321 N N . TRP A 1 290 ? 10.582 54.397 -4.514 1.00 20.79 ? 290 TRP A N 1 ATOM 2322 C CA . TRP A 1 290 ? 11.456 55.422 -5.084 1.00 18.78 ? 290 TRP A CA 1 ATOM 2323 C C . TRP A 1 290 ? 11.448 56.623 -4.135 1.00 19.31 ? 290 TRP A C 1 ATOM 2324 O O . TRP A 1 290 ? 10.430 56.907 -3.500 1.00 18.51 ? 290 TRP A O 1 ATOM 2325 C CB . TRP A 1 290 ? 10.925 55.935 -6.425 1.00 19.58 ? 290 TRP A CB 1 ATOM 2326 C CG . TRP A 1 290 ? 11.141 55.077 -7.628 1.00 20.51 ? 290 TRP A CG 1 ATOM 2327 C CD1 . TRP A 1 290 ? 10.213 54.293 -8.251 1.00 19.59 ? 290 TRP A CD1 1 ATOM 2328 C CD2 . TRP A 1 290 ? 12.327 55.008 -8.428 1.00 20.01 ? 290 TRP A CD2 1 ATOM 2329 N NE1 . TRP A 1 290 ? 10.743 53.749 -9.395 1.00 21.36 ? 290 TRP A NE1 1 ATOM 2330 C CE2 . TRP A 1 290 ? 12.040 54.171 -9.529 1.00 20.39 ? 290 TRP A CE2 1 ATOM 2331 C CE3 . TRP A 1 290 ? 13.603 55.577 -8.324 1.00 20.01 ? 290 TRP A CE3 1 ATOM 2332 C CZ2 . TRP A 1 290 ? 12.982 53.889 -10.524 1.00 19.78 ? 290 TRP A CZ2 1 ATOM 2333 C CZ3 . TRP A 1 290 ? 14.544 55.297 -9.318 1.00 20.65 ? 290 TRP A CZ3 1 ATOM 2334 C CH2 . TRP A 1 290 ? 14.225 54.461 -10.402 1.00 20.45 ? 290 TRP A CH2 1 ATOM 2335 N N . ALA A 1 291 ? 12.565 57.339 -4.052 1.00 17.11 ? 291 ALA A N 1 ATOM 2336 C CA . ALA A 1 291 ? 12.625 58.526 -3.210 1.00 18.60 ? 291 ALA A CA 1 ATOM 2337 C C . ALA A 1 291 ? 13.639 59.526 -3.735 1.00 20.08 ? 291 ALA A C 1 ATOM 2338 O O . ALA A 1 291 ? 14.687 59.157 -4.269 1.00 20.66 ? 291 ALA A O 1 ATOM 2339 C CB . ALA A 1 291 ? 12.962 58.160 -1.763 1.00 17.26 ? 291 ALA A CB 1 ATOM 2340 N N . TRP A 1 292 ? 13.307 60.801 -3.584 1.00 19.93 ? 292 TRP A N 1 ATOM 2341 C CA . TRP A 1 292 ? 14.185 61.870 -4.010 1.00 20.13 ? 292 TRP A CA 1 ATOM 2342 C C . TRP A 1 292 ? 15.233 62.068 -2.921 1.00 20.13 ? 292 TRP A C 1 ATOM 2343 O O . TRP A 1 292 ? 14.911 62.061 -1.734 1.00 20.73 ? 292 TRP A O 1 ATOM 2344 C CB . TRP A 1 292 ? 13.373 63.156 -4.214 1.00 20.70 ? 292 TRP A CB 1 ATOM 2345 C CG . TRP A 1 292 ? 14.193 64.415 -4.311 1.00 23.52 ? 292 TRP A CG 1 ATOM 2346 C CD1 . TRP A 1 292 ? 15.259 64.646 -5.137 1.00 23.03 ? 292 TRP A CD1 1 ATOM 2347 C CD2 . TRP A 1 292 ? 13.997 65.623 -3.562 1.00 23.19 ? 292 TRP A CD2 1 ATOM 2348 N NE1 . TRP A 1 292 ? 15.739 65.923 -4.947 1.00 23.06 ? 292 TRP A NE1 1 ATOM 2349 C CE2 . TRP A 1 292 ? 14.984 66.543 -3.986 1.00 23.76 ? 292 TRP A CE2 1 ATOM 2350 C CE3 . TRP A 1 292 ? 13.083 66.015 -2.572 1.00 21.89 ? 292 TRP A CE3 1 ATOM 2351 C CZ2 . TRP A 1 292 ? 15.085 67.835 -3.453 1.00 24.18 ? 292 TRP A CZ2 1 ATOM 2352 C CZ3 . TRP A 1 292 ? 13.182 67.297 -2.041 1.00 21.80 ? 292 TRP A CZ3 1 ATOM 2353 C CH2 . TRP A 1 292 ? 14.179 68.193 -2.484 1.00 23.29 ? 292 TRP A CH2 1 ATOM 2354 N N . VAL A 1 293 ? 16.488 62.208 -3.325 1.00 18.58 ? 293 VAL A N 1 ATOM 2355 C CA . VAL A 1 293 ? 17.565 62.440 -2.380 1.00 19.35 ? 293 VAL A CA 1 ATOM 2356 C C . VAL A 1 293 ? 18.139 63.811 -2.725 1.00 20.76 ? 293 VAL A C 1 ATOM 2357 O O . VAL A 1 293 ? 18.883 63.962 -3.696 1.00 20.48 ? 293 VAL A O 1 ATOM 2358 C CB . VAL A 1 293 ? 18.664 61.367 -2.495 1.00 19.33 ? 293 VAL A CB 1 ATOM 2359 C CG1 . VAL A 1 293 ? 19.782 61.671 -1.516 1.00 17.21 ? 293 VAL A CG1 1 ATOM 2360 C CG2 . VAL A 1 293 ? 18.079 59.989 -2.215 1.00 16.38 ? 293 VAL A CG2 1 ATOM 2361 N N . PRO A 1 294 ? 17.785 64.833 -1.934 1.00 20.63 ? 294 PRO A N 1 ATOM 2362 C CA . PRO A 1 294 ? 18.243 66.212 -2.134 1.00 21.70 ? 294 PRO A CA 1 ATOM 2363 C C . PRO A 1 294 ? 19.758 66.380 -2.076 1.00 23.45 ? 294 PRO A C 1 ATOM 2364 O O . PRO A 1 294 ? 20.481 65.502 -1.597 1.00 22.64 ? 294 PRO A O 1 ATOM 2365 C CB . PRO A 1 294 ? 17.562 66.979 -0.996 1.00 20.69 ? 294 PRO A CB 1 ATOM 2366 C CG . PRO A 1 294 ? 16.380 66.133 -0.642 1.00 20.50 ? 294 PRO A CG 1 ATOM 2367 C CD . PRO A 1 294 ? 16.929 64.736 -0.740 1.00 20.22 ? 294 PRO A CD 1 ATOM 2368 N N . GLU A 1 295 ? 20.225 67.522 -2.565 1.00 24.41 ? 295 GLU A N 1 ATOM 2369 C CA . GLU A 1 295 ? 21.643 67.846 -2.534 1.00 25.83 ? 295 GLU A CA 1 ATOM 2370 C C . GLU A 1 295 ? 21.910 68.421 -1.148 1.00 25.42 ? 295 GLU A C 1 ATOM 2371 O O . GLU A 1 295 ? 21.008 68.985 -0.531 1.00 25.61 ? 295 GLU A O 1 ATOM 2372 C CB . GLU A 1 295 ? 21.973 68.920 -3.571 1.00 25.40 ? 295 GLU A CB 1 ATOM 2373 C CG . GLU A 1 295 ? 21.784 68.503 -5.008 1.00 26.97 ? 295 GLU A CG 1 ATOM 2374 C CD . GLU A 1 295 ? 22.750 67.418 -5.410 1.00 27.93 ? 295 GLU A CD 1 ATOM 2375 O OE1 . GLU A 1 295 ? 23.968 67.620 -5.223 1.00 28.67 ? 295 GLU A OE1 1 ATOM 2376 O OE2 . GLU A 1 295 ? 22.295 66.370 -5.914 1.00 27.86 ? 295 GLU A OE2 1 ATOM 2377 N N . THR A 1 296 ? 23.130 68.264 -0.649 1.00 25.74 ? 296 THR A N 1 ATOM 2378 C CA . THR A 1 296 ? 23.478 68.837 0.644 1.00 25.29 ? 296 THR A CA 1 ATOM 2379 C C . THR A 1 296 ? 24.633 69.814 0.455 1.00 26.11 ? 296 THR A C 1 ATOM 2380 O O . THR A 1 296 ? 25.232 70.284 1.422 1.00 27.80 ? 296 THR A O 1 ATOM 2381 C CB . THR A 1 296 ? 23.854 67.770 1.696 1.00 24.74 ? 296 THR A CB 1 ATOM 2382 O OG1 . THR A 1 296 ? 24.808 66.856 1.147 1.00 25.73 ? 296 THR A OG1 1 ATOM 2383 C CG2 . THR A 1 296 ? 22.612 67.021 2.152 1.00 22.89 ? 296 THR A CG2 1 ATOM 2384 N N . ASP A 1 297 ? 24.955 70.108 -0.802 1.00 25.55 ? 297 ASP A N 1 ATOM 2385 C CA . ASP A 1 297 ? 25.995 71.086 -1.094 1.00 25.88 ? 297 ASP A CA 1 ATOM 2386 C C . ASP A 1 297 ? 25.216 72.395 -1.277 1.00 26.00 ? 297 ASP A C 1 ATOM 2387 O O . ASP A 1 297 ? 23.991 72.403 -1.118 1.00 24.27 ? 297 ASP A O 1 ATOM 2388 C CB . ASP A 1 297 ? 26.785 70.698 -2.355 1.00 24.01 ? 297 ASP A CB 1 ATOM 2389 C CG . ASP A 1 297 ? 25.931 70.664 -3.607 1.00 25.86 ? 297 ASP A CG 1 ATOM 2390 O OD1 . ASP A 1 297 ? 24.696 70.824 -3.505 1.00 25.99 ? 297 ASP A OD1 1 ATOM 2391 O OD2 . ASP A 1 297 ? 26.504 70.471 -4.703 1.00 24.50 ? 297 ASP A OD2 1 ATOM 2392 N N . SER A 1 298 ? 25.889 73.494 -1.601 1.00 26.43 ? 298 SER A N 1 ATOM 2393 C CA . SER A 1 298 ? 25.180 74.770 -1.745 1.00 27.76 ? 298 SER A CA 1 ATOM 2394 C C . SER A 1 298 ? 24.508 74.954 -3.102 1.00 28.16 ? 298 SER A C 1 ATOM 2395 O O . SER A 1 298 ? 24.840 74.270 -4.076 1.00 28.33 ? 298 SER A O 1 ATOM 2396 C CB . SER A 1 298 ? 26.135 75.940 -1.508 1.00 26.38 ? 298 SER A CB 1 ATOM 2397 O OG . SER A 1 298 ? 26.951 76.157 -2.650 1.00 30.47 ? 298 SER A OG 1 ATOM 2398 N N . GLN A 1 299 ? 23.563 75.888 -3.162 1.00 27.78 ? 299 GLN A N 1 ATOM 2399 C CA . GLN A 1 299 ? 22.870 76.169 -4.410 1.00 29.83 ? 299 GLN A CA 1 ATOM 2400 C C . GLN A 1 299 ? 23.871 76.621 -5.468 1.00 29.19 ? 299 GLN A C 1 ATOM 2401 O O . GLN A 1 299 ? 23.756 76.261 -6.642 1.00 29.18 ? 299 GLN A O 1 ATOM 2402 C CB . GLN A 1 299 ? 21.819 77.257 -4.216 1.00 31.25 ? 299 GLN A CB 1 ATOM 2403 C CG . GLN A 1 299 ? 21.240 77.746 -5.532 1.00 33.42 ? 299 GLN A CG 1 ATOM 2404 C CD . GLN A 1 299 ? 20.088 78.700 -5.342 1.00 36.20 ? 299 GLN A CD 1 ATOM 2405 O OE1 . GLN A 1 299 ? 19.006 78.305 -4.905 1.00 36.24 ? 299 GLN A OE1 1 ATOM 2406 N NE2 . GLN A 1 299 ? 20.313 79.970 -5.665 1.00 36.48 ? 299 GLN A NE2 1 ATOM 2407 N N . ALA A 1 300 ? 24.848 77.417 -5.048 1.00 28.05 ? 300 ALA A N 1 ATOM 2408 C CA . ALA A 1 300 ? 25.874 77.895 -5.964 1.00 27.88 ? 300 ALA A CA 1 ATOM 2409 C C . ALA A 1 300 ? 26.621 76.691 -6.519 1.00 28.14 ? 300 ALA A C 1 ATOM 2410 O O . ALA A 1 300 ? 26.987 76.669 -7.694 1.00 28.44 ? 300 ALA A O 1 ATOM 2411 C CB . ALA A 1 300 ? 26.841 78.829 -5.239 1.00 25.55 ? 300 ALA A CB 1 ATOM 2412 N N . ASP A 1 301 ? 26.848 75.688 -5.669 1.00 28.81 ? 301 ASP A N 1 ATOM 2413 C CA . ASP A 1 301 ? 27.540 74.479 -6.107 1.00 28.76 ? 301 ASP A CA 1 ATOM 2414 C C . ASP A 1 301 ? 26.721 73.772 -7.180 1.00 27.41 ? 301 ASP A C 1 ATOM 2415 O O . ASP A 1 301 ? 27.269 73.320 -8.183 1.00 27.28 ? 301 ASP A O 1 ATOM 2416 C CB . ASP A 1 301 ? 27.778 73.516 -4.936 1.00 30.50 ? 301 ASP A CB 1 ATOM 2417 C CG . ASP A 1 301 ? 28.765 74.061 -3.917 1.00 33.70 ? 301 ASP A CG 1 ATOM 2418 O OD1 . ASP A 1 301 ? 29.797 74.632 -4.331 1.00 36.88 ? 301 ASP A OD1 1 ATOM 2419 O OD2 . ASP A 1 301 ? 28.517 73.906 -2.701 1.00 34.09 ? 301 ASP A OD2 1 ATOM 2420 N N . ASP A 1 302 ? 25.408 73.683 -6.969 1.00 26.47 ? 302 ASP A N 1 ATOM 2421 C CA . ASP A 1 302 ? 24.522 73.024 -7.928 1.00 26.96 ? 302 ASP A CA 1 ATOM 2422 C C . ASP A 1 302 ? 24.538 73.727 -9.277 1.00 27.00 ? 302 ASP A C 1 ATOM 2423 O O . ASP A 1 302 ? 24.655 73.085 -10.324 1.00 27.03 ? 302 ASP A O 1 ATOM 2424 C CB . ASP A 1 302 ? 23.087 72.976 -7.397 1.00 26.79 ? 302 ASP A CB 1 ATOM 2425 C CG . ASP A 1 302 ? 22.980 72.224 -6.090 1.00 27.61 ? 302 ASP A CG 1 ATOM 2426 O OD1 . ASP A 1 302 ? 23.831 71.337 -5.853 1.00 27.09 ? 302 ASP A OD1 1 ATOM 2427 O OD2 . ASP A 1 302 ? 22.045 72.510 -5.308 1.00 27.03 ? 302 ASP A OD2 1 ATOM 2428 N N . ILE A 1 303 ? 24.411 75.049 -9.244 1.00 27.20 ? 303 ILE A N 1 ATOM 2429 C CA . ILE A 1 303 ? 24.426 75.849 -10.461 1.00 28.20 ? 303 ILE A CA 1 ATOM 2430 C C . ILE A 1 303 ? 25.765 75.676 -11.165 1.00 29.62 ? 303 ILE A C 1 ATOM 2431 O O . ILE A 1 303 ? 25.828 75.559 -12.390 1.00 30.97 ? 303 ILE A O 1 ATOM 2432 C CB . ILE A 1 303 ? 24.217 77.343 -10.138 1.00 28.71 ? 303 ILE A CB 1 ATOM 2433 C CG1 . ILE A 1 303 ? 22.799 77.560 -9.608 1.00 27.23 ? 303 ILE A CG1 1 ATOM 2434 C CG2 . ILE A 1 303 ? 24.468 78.192 -11.375 1.00 26.38 ? 303 ILE A CG2 1 ATOM 2435 C CD1 . ILE A 1 303 ? 22.554 78.961 -9.093 1.00 26.42 ? 303 ILE A CD1 1 ATOM 2436 N N . GLU A 1 304 ? 26.836 75.645 -10.381 1.00 30.59 ? 304 GLU A N 1 ATOM 2437 C CA . GLU A 1 304 ? 28.172 75.490 -10.936 1.00 32.35 ? 304 GLU A CA 1 ATOM 2438 C C . GLU A 1 304 ? 28.350 74.118 -11.593 1.00 31.45 ? 304 GLU A C 1 ATOM 2439 O O . GLU A 1 304 ? 28.844 74.035 -12.719 1.00 31.13 ? 304 GLU A O 1 ATOM 2440 C CB . GLU A 1 304 ? 29.224 75.706 -9.837 1.00 36.30 ? 304 GLU A CB 1 ATOM 2441 C CG . GLU A 1 304 ? 30.622 76.040 -10.352 1.00 44.18 ? 304 GLU A CG 1 ATOM 2442 C CD . GLU A 1 304 ? 31.335 74.845 -10.973 1.00 51.22 ? 304 GLU A CD 1 ATOM 2443 O OE1 . GLU A 1 304 ? 32.300 75.058 -11.745 1.00 53.49 ? 304 GLU A OE1 1 ATOM 2444 O OE2 . GLU A 1 304 ? 30.941 73.691 -10.682 1.00 53.57 ? 304 GLU A OE2 1 ATOM 2445 N N . LYS A 1 305 ? 27.949 73.043 -10.910 1.00 28.94 ? 305 LYS A N 1 ATOM 2446 C CA . LYS A 1 305 ? 28.110 71.715 -11.494 1.00 26.56 ? 305 LYS A CA 1 ATOM 2447 C C . LYS A 1 305 ? 27.026 71.391 -12.519 1.00 26.33 ? 305 LYS A C 1 ATOM 2448 O O . LYS A 1 305 ? 27.128 70.409 -13.249 1.00 25.30 ? 305 LYS A O 1 ATOM 2449 C CB . LYS A 1 305 ? 28.201 70.630 -10.404 1.00 26.85 ? 305 LYS A CB 1 ATOM 2450 C CG . LYS A 1 305 ? 26.934 70.281 -9.621 1.00 25.81 ? 305 LYS A CG 1 ATOM 2451 C CD . LYS A 1 305 ? 27.299 69.273 -8.513 1.00 25.74 ? 305 LYS A CD 1 ATOM 2452 C CE . LYS A 1 305 ? 26.092 68.549 -7.899 1.00 25.23 ? 305 LYS A CE 1 ATOM 2453 N NZ . LYS A 1 305 ? 25.181 69.429 -7.113 1.00 25.10 ? 305 LYS A NZ 1 ATOM 2454 N N . GLY A 1 306 ? 25.992 72.229 -12.575 1.00 27.17 ? 306 GLY A N 1 ATOM 2455 C CA . GLY A 1 306 ? 24.933 72.049 -13.557 1.00 26.44 ? 306 GLY A CA 1 ATOM 2456 C C . GLY A 1 306 ? 23.777 71.103 -13.289 1.00 27.38 ? 306 GLY A C 1 ATOM 2457 O O . GLY A 1 306 ? 22.948 70.887 -14.174 1.00 27.73 ? 306 GLY A O 1 ATOM 2458 N N . TRP A 1 307 ? 23.706 70.527 -12.095 1.00 26.72 ? 307 TRP A N 1 ATOM 2459 C CA . TRP A 1 307 ? 22.611 69.618 -11.781 1.00 25.77 ? 307 TRP A CA 1 ATOM 2460 C C . TRP A 1 307 ? 22.367 69.507 -10.289 1.00 25.81 ? 307 TRP A C 1 ATOM 2461 O O . TRP A 1 307 ? 23.215 69.869 -9.470 1.00 26.15 ? 307 TRP A O 1 ATOM 2462 C CB . TRP A 1 307 ? 22.871 68.220 -12.360 1.00 25.20 ? 307 TRP A CB 1 ATOM 2463 C CG . TRP A 1 307 ? 24.125 67.575 -11.862 1.00 25.52 ? 307 TRP A CG 1 ATOM 2464 C CD1 . TRP A 1 307 ? 25.376 67.705 -12.389 1.00 25.20 ? 307 TRP A CD1 1 ATOM 2465 C CD2 . TRP A 1 307 ? 24.257 66.729 -10.710 1.00 24.03 ? 307 TRP A CD2 1 ATOM 2466 N NE1 . TRP A 1 307 ? 26.284 66.995 -11.635 1.00 27.19 ? 307 TRP A NE1 1 ATOM 2467 C CE2 . TRP A 1 307 ? 25.623 66.386 -10.599 1.00 24.88 ? 307 TRP A CE2 1 ATOM 2468 C CE3 . TRP A 1 307 ? 23.355 66.231 -9.759 1.00 24.04 ? 307 TRP A CE3 1 ATOM 2469 C CZ2 . TRP A 1 307 ? 26.112 65.565 -9.574 1.00 24.78 ? 307 TRP A CZ2 1 ATOM 2470 C CZ3 . TRP A 1 307 ? 23.838 65.414 -8.735 1.00 24.22 ? 307 TRP A CZ3 1 ATOM 2471 C CH2 . TRP A 1 307 ? 25.208 65.090 -8.654 1.00 25.41 ? 307 TRP A CH2 1 ATOM 2472 N N . ALA A 1 308 ? 21.194 69.001 -9.936 1.00 24.90 ? 308 ALA A N 1 ATOM 2473 C CA . ALA A 1 308 ? 20.844 68.841 -8.540 1.00 23.42 ? 308 ALA A CA 1 ATOM 2474 C C . ALA A 1 308 ? 19.728 67.821 -8.379 1.00 23.37 ? 308 ALA A C 1 ATOM 2475 O O . ALA A 1 308 ? 18.732 67.843 -9.113 1.00 22.78 ? 308 ALA A O 1 ATOM 2476 C CB . ALA A 1 308 ? 20.424 70.183 -7.952 1.00 21.52 ? 308 ALA A CB 1 ATOM 2477 N N . GLY A 1 309 ? 19.913 66.923 -7.416 1.00 21.90 ? 309 GLY A N 1 ATOM 2478 C CA . GLY A 1 309 ? 18.918 65.907 -7.142 1.00 20.09 ? 309 GLY A CA 1 ATOM 2479 C C . GLY A 1 309 ? 19.251 64.521 -7.662 1.00 20.19 ? 309 GLY A C 1 ATOM 2480 O O . GLY A 1 309 ? 19.774 64.361 -8.765 1.00 18.49 ? 309 GLY A O 1 ATOM 2481 N N . LEU A 1 310 ? 18.948 63.516 -6.847 1.00 19.07 ? 310 LEU A N 1 ATOM 2482 C CA . LEU A 1 310 ? 19.165 62.121 -7.208 1.00 19.68 ? 310 LEU A CA 1 ATOM 2483 C C . LEU A 1 310 ? 17.940 61.357 -6.746 1.00 20.50 ? 310 LEU A C 1 ATOM 2484 O O . LEU A 1 310 ? 17.122 61.874 -5.985 1.00 20.96 ? 310 LEU A O 1 ATOM 2485 C CB . LEU A 1 310 ? 20.378 61.530 -6.478 1.00 19.22 ? 310 LEU A CB 1 ATOM 2486 C CG . LEU A 1 310 ? 21.800 62.037 -6.720 1.00 19.53 ? 310 LEU A CG 1 ATOM 2487 C CD1 . LEU A 1 310 ? 22.744 61.321 -5.770 1.00 18.99 ? 310 LEU A CD1 1 ATOM 2488 C CD2 . LEU A 1 310 ? 22.206 61.794 -8.161 1.00 19.74 ? 310 LEU A CD2 1 ATOM 2489 N N . GLN A 1 311 ? 17.806 60.130 -7.228 1.00 20.73 ? 311 GLN A N 1 ATOM 2490 C CA . GLN A 1 311 ? 16.731 59.263 -6.784 1.00 20.59 ? 311 GLN A CA 1 ATOM 2491 C C . GLN A 1 311 ? 17.490 58.169 -6.044 1.00 21.61 ? 311 GLN A C 1 ATOM 2492 O O . GLN A 1 311 ? 18.608 57.816 -6.431 1.00 21.63 ? 311 GLN A O 1 ATOM 2493 C CB . GLN A 1 311 ? 15.972 58.647 -7.965 1.00 19.86 ? 311 GLN A CB 1 ATOM 2494 C CG . GLN A 1 311 ? 15.068 59.601 -8.732 1.00 21.77 ? 311 GLN A CG 1 ATOM 2495 C CD . GLN A 1 311 ? 13.971 60.216 -7.870 1.00 22.69 ? 311 GLN A CD 1 ATOM 2496 O OE1 . GLN A 1 311 ? 13.255 59.514 -7.146 1.00 22.36 ? 311 GLN A OE1 1 ATOM 2497 N NE2 . GLN A 1 311 ? 13.827 61.532 -7.954 1.00 21.46 ? 311 GLN A NE2 1 ATOM 2498 N N . SER A 1 312 ? 16.919 57.659 -4.963 1.00 21.67 ? 312 SER A N 1 ATOM 2499 C CA . SER A 1 312 ? 17.556 56.572 -4.235 1.00 20.49 ? 312 SER A CA 1 ATOM 2500 C C . SER A 1 312 ? 17.449 55.361 -5.163 1.00 21.68 ? 312 SER A C 1 ATOM 2501 O O . SER A 1 312 ? 16.665 55.373 -6.111 1.00 21.39 ? 312 SER A O 1 ATOM 2502 C CB . SER A 1 312 ? 16.790 56.293 -2.948 1.00 19.71 ? 312 SER A CB 1 ATOM 2503 O OG . SER A 1 312 ? 15.411 56.121 -3.236 1.00 19.80 ? 312 SER A OG 1 ATOM 2504 N N . PHE A 1 313 ? 18.232 54.320 -4.919 1.00 22.01 ? 313 PHE A N 1 ATOM 2505 C CA . PHE A 1 313 ? 18.124 53.148 -5.771 1.00 20.91 ? 313 PHE A CA 1 ATOM 2506 C C . PHE A 1 313 ? 16.821 52.438 -5.397 1.00 21.94 ? 313 PHE A C 1 ATOM 2507 O O . PHE A 1 313 ? 16.519 52.264 -4.212 1.00 21.70 ? 313 PHE A O 1 ATOM 2508 C CB . PHE A 1 313 ? 19.303 52.207 -5.560 1.00 19.05 ? 313 PHE A CB 1 ATOM 2509 C CG . PHE A 1 313 ? 19.334 51.075 -6.535 1.00 19.74 ? 313 PHE A CG 1 ATOM 2510 C CD1 . PHE A 1 313 ? 19.764 51.281 -7.839 1.00 20.33 ? 313 PHE A CD1 1 ATOM 2511 C CD2 . PHE A 1 313 ? 18.870 49.815 -6.172 1.00 20.80 ? 313 PHE A CD2 1 ATOM 2512 C CE1 . PHE A 1 313 ? 19.728 50.253 -8.773 1.00 21.74 ? 313 PHE A CE1 1 ATOM 2513 C CE2 . PHE A 1 313 ? 18.831 48.779 -7.099 1.00 20.96 ? 313 PHE A CE2 1 ATOM 2514 C CZ . PHE A 1 313 ? 19.258 48.999 -8.402 1.00 21.47 ? 313 PHE A CZ 1 ATOM 2515 N N . PRO A 1 314 ? 16.034 52.013 -6.399 1.00 21.25 ? 314 PRO A N 1 ATOM 2516 C CA . PRO A 1 314 ? 14.758 51.326 -6.156 1.00 20.49 ? 314 PRO A CA 1 ATOM 2517 C C . PRO A 1 314 ? 14.877 50.211 -5.125 1.00 21.29 ? 314 PRO A C 1 ATOM 2518 O O . PRO A 1 314 ? 15.706 49.317 -5.273 1.00 20.57 ? 314 PRO A O 1 ATOM 2519 C CB . PRO A 1 314 ? 14.394 50.768 -7.531 1.00 20.08 ? 314 PRO A CB 1 ATOM 2520 C CG . PRO A 1 314 ? 15.029 51.723 -8.473 1.00 21.53 ? 314 PRO A CG 1 ATOM 2521 C CD . PRO A 1 314 ? 16.369 51.998 -7.834 1.00 22.08 ? 314 PRO A CD 1 ATOM 2522 N N . ARG A 1 315 ? 14.071 50.258 -4.069 1.00 22.06 ? 315 ARG A N 1 ATOM 2523 C CA . ARG A 1 315 ? 14.139 49.180 -3.100 1.00 23.14 ? 315 ARG A CA 1 ATOM 2524 C C . ARG A 1 315 ? 12.830 48.430 -2.923 1.00 23.23 ? 315 ARG A C 1 ATOM 2525 O O . ARG A 1 315 ? 11.742 49.001 -3.013 1.00 24.09 ? 315 ARG A O 1 ATOM 2526 C CB . ARG A 1 315 ? 14.684 49.658 -1.733 1.00 23.49 ? 315 ARG A CB 1 ATOM 2527 C CG . ARG A 1 315 ? 14.453 51.098 -1.351 1.00 23.79 ? 315 ARG A CG 1 ATOM 2528 C CD . ARG A 1 315 ? 15.755 51.746 -0.845 1.00 22.61 ? 315 ARG A CD 1 ATOM 2529 N NE . ARG A 1 315 ? 15.581 52.401 0.447 1.00 25.81 ? 315 ARG A NE 1 ATOM 2530 C CZ . ARG A 1 315 ? 16.460 53.227 1.014 1.00 23.32 ? 315 ARG A CZ 1 ATOM 2531 N NH1 . ARG A 1 315 ? 17.600 53.531 0.416 1.00 20.69 ? 315 ARG A NH1 1 ATOM 2532 N NH2 . ARG A 1 315 ? 16.198 53.739 2.203 1.00 22.64 ? 315 ARG A NH2 1 ATOM 2533 N N . ALA A 1 316 ? 12.954 47.124 -2.724 1.00 22.36 ? 316 ALA A N 1 ATOM 2534 C CA . ALA A 1 316 ? 11.799 46.273 -2.509 1.00 21.35 ? 316 ALA A CA 1 ATOM 2535 C C . ALA A 1 316 ? 11.343 46.610 -1.095 1.00 21.60 ? 316 ALA A C 1 ATOM 2536 O O . ALA A 1 316 ? 12.161 46.916 -0.224 1.00 20.73 ? 316 ALA A O 1 ATOM 2537 C CB . ALA A 1 316 ? 12.195 44.803 -2.623 1.00 19.04 ? 316 ALA A CB 1 ATOM 2538 N N . LEU A 1 317 ? 10.041 46.543 -0.865 1.00 22.36 ? 317 LEU A N 1 ATOM 2539 C CA . LEU A 1 317 ? 9.484 46.908 0.423 1.00 22.60 ? 317 LEU A CA 1 ATOM 2540 C C . LEU A 1 317 ? 8.489 45.884 0.947 1.00 22.98 ? 317 LEU A C 1 ATOM 2541 O O . LEU A 1 317 ? 7.607 45.437 0.215 1.00 23.96 ? 317 LEU A O 1 ATOM 2542 C CB . LEU A 1 317 ? 8.801 48.267 0.262 1.00 23.91 ? 317 LEU A CB 1 ATOM 2543 C CG . LEU A 1 317 ? 7.945 48.886 1.357 1.00 25.93 ? 317 LEU A CG 1 ATOM 2544 C CD1 . LEU A 1 317 ? 8.821 49.314 2.526 1.00 26.73 ? 317 LEU A CD1 1 ATOM 2545 C CD2 . LEU A 1 317 ? 7.212 50.089 0.769 1.00 26.12 ? 317 LEU A CD2 1 ATOM 2546 N N . TRP A 1 318 ? 8.623 45.518 2.218 1.00 22.48 ? 318 TRP A N 1 ATOM 2547 C CA . TRP A 1 318 ? 7.705 44.559 2.822 1.00 22.51 ? 318 TRP A CA 1 ATOM 2548 C C . TRP A 1 318 ? 7.643 44.735 4.339 1.00 23.41 ? 318 TRP A C 1 ATOM 2549 O O . TRP A 1 318 ? 8.441 45.472 4.918 1.00 23.67 ? 318 TRP A O 1 ATOM 2550 C CB . TRP A 1 318 ? 8.111 43.127 2.440 1.00 21.93 ? 318 TRP A CB 1 ATOM 2551 C CG . TRP A 1 318 ? 9.405 42.638 3.023 1.00 21.47 ? 318 TRP A CG 1 ATOM 2552 C CD1 . TRP A 1 318 ? 9.577 42.011 4.227 1.00 21.93 ? 318 TRP A CD1 1 ATOM 2553 C CD2 . TRP A 1 318 ? 10.705 42.706 2.416 1.00 20.29 ? 318 TRP A CD2 1 ATOM 2554 N NE1 . TRP A 1 318 ? 10.904 41.680 4.404 1.00 22.41 ? 318 TRP A NE1 1 ATOM 2555 C CE2 . TRP A 1 318 ? 11.617 42.095 3.309 1.00 21.39 ? 318 TRP A CE2 1 ATOM 2556 C CE3 . TRP A 1 318 ? 11.186 43.222 1.203 1.00 20.69 ? 318 TRP A CE3 1 ATOM 2557 C CZ2 . TRP A 1 318 ? 12.987 41.986 3.028 1.00 20.56 ? 318 TRP A CZ2 1 ATOM 2558 C CZ3 . TRP A 1 318 ? 12.551 43.115 0.920 1.00 20.34 ? 318 TRP A CZ3 1 ATOM 2559 C CH2 . TRP A 1 318 ? 13.434 42.500 1.832 1.00 21.93 ? 318 TRP A CH2 1 ATOM 2560 N N . ILE A 1 319 ? 6.685 44.079 4.983 1.00 24.09 ? 319 ILE A N 1 ATOM 2561 C CA . ILE A 1 319 ? 6.548 44.204 6.429 1.00 25.54 ? 319 ILE A CA 1 ATOM 2562 C C . ILE A 1 319 ? 7.326 43.117 7.156 1.00 26.44 ? 319 ILE A C 1 ATOM 2563 O O . ILE A 1 319 ? 7.343 41.962 6.734 1.00 26.13 ? 319 ILE A O 1 ATOM 2564 C CB . ILE A 1 319 ? 5.055 44.150 6.867 1.00 26.35 ? 319 ILE A CB 1 ATOM 2565 C CG1 . ILE A 1 319 ? 4.926 44.626 8.317 1.00 25.84 ? 319 ILE A CG1 1 ATOM 2566 C CG2 . ILE A 1 319 ? 4.512 42.730 6.733 1.00 24.12 ? 319 ILE A CG2 1 ATOM 2567 C CD1 . ILE A 1 319 ? 3.499 44.815 8.783 1.00 23.69 ? 319 ILE A CD1 1 ATOM 2568 N N . ASP A 1 320 ? 7.975 43.499 8.249 1.00 28.30 ? 320 ASP A N 1 ATOM 2569 C CA . ASP A 1 320 ? 8.765 42.567 9.042 1.00 29.77 ? 320 ASP A CA 1 ATOM 2570 C C . ASP A 1 320 ? 7.891 41.479 9.659 1.00 30.90 ? 320 ASP A C 1 ATOM 2571 O O . ASP A 1 320 ? 6.698 41.683 9.884 1.00 29.47 ? 320 ASP A O 1 ATOM 2572 C CB . ASP A 1 320 ? 9.509 43.330 10.142 1.00 30.64 ? 320 ASP A CB 1 ATOM 2573 C CG . ASP A 1 320 ? 10.413 42.434 10.966 1.00 32.00 ? 320 ASP A CG 1 ATOM 2574 O OD1 . ASP A 1 320 ? 9.926 41.811 11.930 1.00 34.69 ? 320 ASP A OD1 1 ATOM 2575 O OD2 . ASP A 1 320 ? 11.614 42.340 10.640 1.00 34.66 ? 320 ASP A OD2 1 ATOM 2576 N N . ARG A 1 321 ? 8.490 40.322 9.923 1.00 33.66 ? 321 ARG A N 1 ATOM 2577 C CA . ARG A 1 321 ? 7.772 39.199 10.520 1.00 37.63 ? 321 ARG A CA 1 ATOM 2578 C C . ARG A 1 321 ? 7.101 39.594 11.844 1.00 37.31 ? 321 ARG A C 1 ATOM 2579 O O . ARG A 1 321 ? 6.059 39.051 12.204 1.00 36.79 ? 321 ARG A O 1 ATOM 2580 C CB . ARG A 1 321 ? 8.735 38.030 10.757 1.00 41.83 ? 321 ARG A CB 1 ATOM 2581 C CG . ARG A 1 321 ? 9.873 38.357 11.721 1.00 51.06 ? 321 ARG A CG 1 ATOM 2582 C CD . ARG A 1 321 ? 10.946 37.265 11.747 1.00 57.60 ? 321 ARG A CD 1 ATOM 2583 N NE . ARG A 1 321 ? 11.999 37.535 12.733 1.00 63.70 ? 321 ARG A NE 1 ATOM 2584 C CZ . ARG A 1 321 ? 12.825 38.584 12.706 1.00 66.19 ? 321 ARG A CZ 1 ATOM 2585 N NH1 . ARG A 1 321 ? 12.740 39.492 11.737 1.00 65.31 ? 321 ARG A NH1 1 ATOM 2586 N NH2 . ARG A 1 321 ? 13.743 38.727 13.658 1.00 67.05 ? 321 ARG A NH2 1 ATOM 2587 N N . ASN A 1 322 ? 7.692 40.547 12.558 1.00 36.37 ? 322 ASN A N 1 ATOM 2588 C CA . ASN A 1 322 ? 7.142 40.993 13.833 1.00 36.60 ? 322 ASN A CA 1 ATOM 2589 C C . ASN A 1 322 ? 5.950 41.921 13.617 1.00 35.24 ? 322 ASN A C 1 ATOM 2590 O O . ASN A 1 322 ? 5.257 42.284 14.568 1.00 35.81 ? 322 ASN A O 1 ATOM 2591 C CB . ASN A 1 322 ? 8.220 41.710 14.653 1.00 40.73 ? 322 ASN A CB 1 ATOM 2592 C CG . ASN A 1 322 ? 8.349 43.188 14.296 1.00 45.99 ? 322 ASN A CG 1 ATOM 2593 O OD1 . ASN A 1 322 ? 8.464 43.561 13.125 1.00 46.77 ? 322 ASN A OD1 1 ATOM 2594 N ND2 . ASN A 1 322 ? 8.337 44.037 15.317 1.00 49.44 ? 322 ASN A ND2 1 ATOM 2595 N N . GLY A 1 323 ? 5.733 42.313 12.363 1.00 32.71 ? 323 GLY A N 1 ATOM 2596 C CA . GLY A 1 323 ? 4.617 43.177 12.012 1.00 30.14 ? 323 GLY A CA 1 ATOM 2597 C C . GLY A 1 323 ? 4.608 44.598 12.550 1.00 30.48 ? 323 GLY A C 1 ATOM 2598 O O . GLY A 1 323 ? 3.595 45.288 12.428 1.00 29.17 ? 323 GLY A O 1 ATOM 2599 N N . LYS A 1 324 ? 5.719 45.054 13.124 1.00 30.55 ? 324 LYS A N 1 ATOM 2600 C CA . LYS A 1 324 ? 5.779 46.402 13.691 1.00 31.46 ? 324 LYS A CA 1 ATOM 2601 C C . LYS A 1 324 ? 6.524 47.444 12.858 1.00 29.61 ? 324 LYS A C 1 ATOM 2602 O O . LYS A 1 324 ? 6.512 48.630 13.191 1.00 28.34 ? 324 LYS A O 1 ATOM 2603 C CB . LYS A 1 324 ? 6.379 46.350 15.102 1.00 35.22 ? 324 LYS A CB 1 ATOM 2604 C CG . LYS A 1 324 ? 5.486 45.650 16.119 1.00 40.01 ? 324 LYS A CG 1 ATOM 2605 C CD . LYS A 1 324 ? 6.135 45.590 17.497 1.00 45.53 ? 324 LYS A CD 1 ATOM 2606 C CE . LYS A 1 324 ? 5.181 44.988 18.532 1.00 49.12 ? 324 LYS A CE 1 ATOM 2607 N NZ . LYS A 1 324 ? 5.788 44.892 19.899 1.00 51.55 ? 324 LYS A NZ 1 ATOM 2608 N N . GLN A 1 325 ? 7.179 47.007 11.788 1.00 27.17 ? 325 GLN A N 1 ATOM 2609 C CA . GLN A 1 325 ? 7.893 47.932 10.918 1.00 24.12 ? 325 GLN A CA 1 ATOM 2610 C C . GLN A 1 325 ? 8.081 47.371 9.521 1.00 23.59 ? 325 GLN A C 1 ATOM 2611 O O . GLN A 1 325 ? 7.842 46.190 9.266 1.00 24.69 ? 325 GLN A O 1 ATOM 2612 C CB . GLN A 1 325 ? 9.263 48.297 11.496 1.00 23.31 ? 325 GLN A CB 1 ATOM 2613 C CG . GLN A 1 325 ? 10.259 47.155 11.555 1.00 22.85 ? 325 GLN A CG 1 ATOM 2614 C CD . GLN A 1 325 ? 11.697 47.651 11.570 1.00 25.45 ? 325 GLN A CD 1 ATOM 2615 O OE1 . GLN A 1 325 ? 12.202 48.156 10.562 1.00 25.95 ? 325 GLN A OE1 1 ATOM 2616 N NE2 . GLN A 1 325 ? 12.360 47.520 12.716 1.00 21.91 ? 325 GLN A NE2 1 ATOM 2617 N N . LEU A 1 326 ? 8.509 48.240 8.617 1.00 23.18 ? 326 LEU A N 1 ATOM 2618 C CA . LEU A 1 326 ? 8.756 47.868 7.235 1.00 22.91 ? 326 LEU A CA 1 ATOM 2619 C C . LEU A 1 326 ? 10.236 47.554 7.022 1.00 22.79 ? 326 LEU A C 1 ATOM 2620 O O . LEU A 1 326 ? 11.098 48.012 7.776 1.00 22.36 ? 326 LEU A O 1 ATOM 2621 C CB . LEU A 1 326 ? 8.327 49.010 6.314 1.00 22.18 ? 326 LEU A CB 1 ATOM 2622 C CG . LEU A 1 326 ? 6.907 49.016 5.738 1.00 23.31 ? 326 LEU A CG 1 ATOM 2623 C CD1 . LEU A 1 326 ? 5.936 48.312 6.652 1.00 21.40 ? 326 LEU A CD1 1 ATOM 2624 C CD2 . LEU A 1 326 ? 6.494 50.459 5.487 1.00 22.24 ? 326 LEU A CD2 1 ATOM 2625 N N . ILE A 1 327 ? 10.515 46.762 5.993 1.00 21.74 ? 327 ILE A N 1 ATOM 2626 C CA . ILE A 1 327 ? 11.871 46.373 5.644 1.00 20.50 ? 327 ILE A CA 1 ATOM 2627 C C . ILE A 1 327 ? 12.106 46.811 4.198 1.00 21.90 ? 327 ILE A C 1 ATOM 2628 O O . ILE A 1 327 ? 11.199 46.709 3.365 1.00 22.31 ? 327 ILE A O 1 ATOM 2629 C CB . ILE A 1 327 ? 12.049 44.835 5.703 1.00 20.82 ? 327 ILE A CB 1 ATOM 2630 C CG1 . ILE A 1 327 ? 11.587 44.286 7.059 1.00 20.94 ? 327 ILE A CG1 1 ATOM 2631 C CG2 . ILE A 1 327 ? 13.501 44.475 5.425 1.00 17.83 ? 327 ILE A CG2 1 ATOM 2632 C CD1 . ILE A 1 327 ? 12.468 44.649 8.221 1.00 21.37 ? 327 ILE A CD1 1 ATOM 2633 N N . GLN A 1 328 ? 13.314 47.287 3.901 1.00 20.96 ? 328 GLN A N 1 ATOM 2634 C CA . GLN A 1 328 ? 13.663 47.713 2.545 1.00 19.86 ? 328 GLN A CA 1 ATOM 2635 C C . GLN A 1 328 ? 14.966 47.055 2.099 1.00 20.35 ? 328 GLN A C 1 ATOM 2636 O O . GLN A 1 328 ? 15.850 46.793 2.915 1.00 20.49 ? 328 GLN A O 1 ATOM 2637 C CB . GLN A 1 328 ? 13.837 49.225 2.482 1.00 19.54 ? 328 GLN A CB 1 ATOM 2638 C CG . GLN A 1 328 ? 12.572 50.028 2.641 1.00 19.77 ? 328 GLN A CG 1 ATOM 2639 C CD . GLN A 1 328 ? 12.874 51.392 3.214 1.00 23.46 ? 328 GLN A CD 1 ATOM 2640 O OE1 . GLN A 1 328 ? 12.868 51.581 4.438 1.00 22.32 ? 328 GLN A OE1 1 ATOM 2641 N NE2 . GLN A 1 328 ? 13.179 52.345 2.341 1.00 20.48 ? 328 GLN A NE2 1 ATOM 2642 N N . TRP A 1 329 ? 15.090 46.811 0.800 1.00 18.96 ? 329 TRP A N 1 ATOM 2643 C CA . TRP A 1 329 ? 16.287 46.182 0.264 1.00 20.11 ? 329 TRP A CA 1 ATOM 2644 C C . TRP A 1 329 ? 16.379 46.529 -1.219 1.00 20.88 ? 329 TRP A C 1 ATOM 2645 O O . TRP A 1 329 ? 15.367 46.548 -1.919 1.00 19.61 ? 329 TRP A O 1 ATOM 2646 C CB . TRP A 1 329 ? 16.194 44.662 0.448 1.00 19.31 ? 329 TRP A CB 1 ATOM 2647 C CG . TRP A 1 329 ? 17.515 43.942 0.414 1.00 21.41 ? 329 TRP A CG 1 ATOM 2648 C CD1 . TRP A 1 329 ? 17.925 43.022 -0.513 1.00 19.79 ? 329 TRP A CD1 1 ATOM 2649 C CD2 . TRP A 1 329 ? 18.578 44.043 1.376 1.00 19.83 ? 329 TRP A CD2 1 ATOM 2650 N NE1 . TRP A 1 329 ? 19.170 42.542 -0.183 1.00 20.73 ? 329 TRP A NE1 1 ATOM 2651 C CE2 . TRP A 1 329 ? 19.594 43.151 0.971 1.00 20.70 ? 329 TRP A CE2 1 ATOM 2652 C CE3 . TRP A 1 329 ? 18.768 44.802 2.542 1.00 22.43 ? 329 TRP A CE3 1 ATOM 2653 C CZ2 . TRP A 1 329 ? 20.789 42.993 1.692 1.00 21.19 ? 329 TRP A CZ2 1 ATOM 2654 C CZ3 . TRP A 1 329 ? 19.958 44.647 3.262 1.00 22.44 ? 329 TRP A CZ3 1 ATOM 2655 C CH2 . TRP A 1 329 ? 20.951 43.747 2.831 1.00 22.56 ? 329 TRP A CH2 1 ATOM 2656 N N . PRO A 1 330 ? 17.592 46.829 -1.713 1.00 20.33 ? 330 PRO A N 1 ATOM 2657 C CA . PRO A 1 330 ? 17.761 47.171 -3.128 1.00 19.51 ? 330 PRO A CA 1 ATOM 2658 C C . PRO A 1 330 ? 17.202 46.043 -3.997 1.00 20.81 ? 330 PRO A C 1 ATOM 2659 O O . PRO A 1 330 ? 17.422 44.864 -3.692 1.00 19.92 ? 330 PRO A O 1 ATOM 2660 C CB . PRO A 1 330 ? 19.274 47.312 -3.263 1.00 19.76 ? 330 PRO A CB 1 ATOM 2661 C CG . PRO A 1 330 ? 19.689 47.813 -1.904 1.00 17.96 ? 330 PRO A CG 1 ATOM 2662 C CD . PRO A 1 330 ? 18.867 46.946 -0.982 1.00 20.12 ? 330 PRO A CD 1 ATOM 2663 N N . VAL A 1 331 ? 16.473 46.389 -5.061 1.00 19.40 ? 331 VAL A N 1 ATOM 2664 C CA . VAL A 1 331 ? 15.908 45.365 -5.934 1.00 18.23 ? 331 VAL A CA 1 ATOM 2665 C C . VAL A 1 331 ? 17.039 44.492 -6.458 1.00 20.61 ? 331 VAL A C 1 ATOM 2666 O O . VAL A 1 331 ? 18.130 44.981 -6.765 1.00 21.66 ? 331 VAL A O 1 ATOM 2667 C CB . VAL A 1 331 ? 15.101 45.976 -7.109 1.00 19.15 ? 331 VAL A CB 1 ATOM 2668 C CG1 . VAL A 1 331 ? 13.820 46.598 -6.572 1.00 16.48 ? 331 VAL A CG1 1 ATOM 2669 C CG2 . VAL A 1 331 ? 15.926 47.017 -7.849 1.00 14.08 ? 331 VAL A CG2 1 ATOM 2670 N N . GLU A 1 332 ? 16.773 43.195 -6.536 1.00 21.33 ? 332 GLU A N 1 ATOM 2671 C CA . GLU A 1 332 ? 17.766 42.219 -6.961 1.00 22.95 ? 332 GLU A CA 1 ATOM 2672 C C . GLU A 1 332 ? 18.494 42.511 -8.272 1.00 22.32 ? 332 GLU A C 1 ATOM 2673 O O . GLU A 1 332 ? 19.640 42.090 -8.444 1.00 22.74 ? 332 GLU A O 1 ATOM 2674 C CB . GLU A 1 332 ? 17.125 40.830 -7.016 1.00 23.65 ? 332 GLU A CB 1 ATOM 2675 C CG . GLU A 1 332 ? 16.134 40.643 -8.145 1.00 30.78 ? 332 GLU A CG 1 ATOM 2676 C CD . GLU A 1 332 ? 15.334 39.359 -8.005 1.00 35.20 ? 332 GLU A CD 1 ATOM 2677 O OE1 . GLU A 1 332 ? 15.874 38.372 -7.455 1.00 37.32 ? 332 GLU A OE1 1 ATOM 2678 O OE2 . GLU A 1 332 ? 14.167 39.333 -8.455 1.00 37.99 ? 332 GLU A OE2 1 ATOM 2679 N N . GLU A 1 333 ? 17.850 43.226 -9.191 1.00 21.31 ? 333 GLU A N 1 ATOM 2680 C CA . GLU A 1 333 ? 18.491 43.537 -10.468 1.00 21.67 ? 333 GLU A CA 1 ATOM 2681 C C . GLU A 1 333 ? 19.818 44.281 -10.323 1.00 22.58 ? 333 GLU A C 1 ATOM 2682 O O . GLU A 1 333 ? 20.629 44.276 -11.250 1.00 21.89 ? 333 GLU A O 1 ATOM 2683 C CB . GLU A 1 333 ? 17.562 44.353 -11.375 1.00 21.09 ? 333 GLU A CB 1 ATOM 2684 C CG . GLU A 1 333 ? 16.385 43.579 -11.933 1.00 22.39 ? 333 GLU A CG 1 ATOM 2685 C CD . GLU A 1 333 ? 15.212 43.522 -10.973 1.00 25.88 ? 333 GLU A CD 1 ATOM 2686 O OE1 . GLU A 1 333 ? 15.393 43.850 -9.779 1.00 27.79 ? 333 GLU A OE1 1 ATOM 2687 O OE2 . GLU A 1 333 ? 14.106 43.141 -11.414 1.00 26.82 ? 333 GLU A OE2 1 ATOM 2688 N N . ILE A 1 334 ? 20.043 44.918 -9.173 1.00 20.82 ? 334 ILE A N 1 ATOM 2689 C CA . ILE A 1 334 ? 21.285 45.657 -8.961 1.00 22.15 ? 334 ILE A CA 1 ATOM 2690 C C . ILE A 1 334 ? 22.476 44.708 -8.900 1.00 23.82 ? 334 ILE A C 1 ATOM 2691 O O . ILE A 1 334 ? 23.603 45.082 -9.220 1.00 22.77 ? 334 ILE A O 1 ATOM 2692 C CB . ILE A 1 334 ? 21.257 46.475 -7.644 1.00 22.54 ? 334 ILE A CB 1 ATOM 2693 C CG1 . ILE A 1 334 ? 22.334 47.565 -7.687 1.00 22.13 ? 334 ILE A CG1 1 ATOM 2694 C CG2 . ILE A 1 334 ? 21.524 45.567 -6.446 1.00 17.75 ? 334 ILE A CG2 1 ATOM 2695 C CD1 . ILE A 1 334 ? 22.334 48.483 -6.475 1.00 22.22 ? 334 ILE A CD1 1 ATOM 2696 N N . GLU A 1 335 ? 22.217 43.476 -8.483 1.00 25.46 ? 335 GLU A N 1 ATOM 2697 C CA . GLU A 1 335 ? 23.271 42.483 -8.363 1.00 29.53 ? 335 GLU A CA 1 ATOM 2698 C C . GLU A 1 335 ? 23.971 42.209 -9.691 1.00 30.33 ? 335 GLU A C 1 ATOM 2699 O O . GLU A 1 335 ? 25.097 41.717 -9.719 1.00 29.87 ? 335 GLU A O 1 ATOM 2700 C CB . GLU A 1 335 ? 22.688 41.202 -7.760 1.00 30.87 ? 335 GLU A CB 1 ATOM 2701 C CG . GLU A 1 335 ? 22.371 41.369 -6.272 1.00 35.11 ? 335 GLU A CG 1 ATOM 2702 C CD . GLU A 1 335 ? 21.476 40.278 -5.709 1.00 38.37 ? 335 GLU A CD 1 ATOM 2703 O OE1 . GLU A 1 335 ? 21.658 39.103 -6.102 1.00 37.94 ? 335 GLU A OE1 1 ATOM 2704 O OE2 . GLU A 1 335 ? 20.601 40.604 -4.863 1.00 37.33 ? 335 GLU A OE2 1 ATOM 2705 N N . GLU A 1 336 ? 23.311 42.568 -10.786 1.00 31.52 ? 336 GLU A N 1 ATOM 2706 C CA . GLU A 1 336 ? 23.858 42.366 -12.118 1.00 32.53 ? 336 GLU A CA 1 ATOM 2707 C C . GLU A 1 336 ? 25.004 43.331 -12.424 1.00 31.52 ? 336 GLU A C 1 ATOM 2708 O O . GLU A 1 336 ? 25.737 43.142 -13.395 1.00 32.15 ? 336 GLU A O 1 ATOM 2709 C CB . GLU A 1 336 ? 22.758 42.549 -13.162 1.00 37.76 ? 336 GLU A CB 1 ATOM 2710 C CG . GLU A 1 336 ? 22.968 41.727 -14.413 1.00 47.88 ? 336 GLU A CG 1 ATOM 2711 C CD . GLU A 1 336 ? 22.762 40.236 -14.167 1.00 53.98 ? 336 GLU A CD 1 ATOM 2712 O OE1 . GLU A 1 336 ? 22.986 39.438 -15.109 1.00 57.68 ? 336 GLU A OE1 1 ATOM 2713 O OE2 . GLU A 1 336 ? 22.371 39.864 -13.035 1.00 55.54 ? 336 GLU A OE2 1 ATOM 2714 N N . LEU A 1 337 ? 25.149 44.370 -11.607 1.00 28.44 ? 337 LEU A N 1 ATOM 2715 C CA . LEU A 1 337 ? 26.211 45.352 -11.806 1.00 26.49 ? 337 LEU A CA 1 ATOM 2716 C C . LEU A 1 337 ? 27.512 44.924 -11.127 1.00 25.89 ? 337 LEU A C 1 ATOM 2717 O O . LEU A 1 337 ? 28.572 45.493 -11.382 1.00 25.67 ? 337 LEU A O 1 ATOM 2718 C CB . LEU A 1 337 ? 25.779 46.723 -11.265 1.00 23.81 ? 337 LEU A CB 1 ATOM 2719 C CG . LEU A 1 337 ? 24.557 47.389 -11.915 1.00 24.11 ? 337 LEU A CG 1 ATOM 2720 C CD1 . LEU A 1 337 ? 24.249 48.699 -11.202 1.00 18.68 ? 337 LEU A CD1 1 ATOM 2721 C CD2 . LEU A 1 337 ? 24.819 47.635 -13.402 1.00 19.12 ? 337 LEU A CD2 1 ATOM 2722 N N . ARG A 1 338 ? 27.425 43.918 -10.266 1.00 26.01 ? 338 ARG A N 1 ATOM 2723 C CA . ARG A 1 338 ? 28.592 43.425 -9.540 1.00 27.88 ? 338 ARG A CA 1 ATOM 2724 C C . ARG A 1 338 ? 29.676 42.851 -10.447 1.00 28.87 ? 338 ARG A C 1 ATOM 2725 O O . ARG A 1 338 ? 29.411 41.980 -11.274 1.00 29.49 ? 338 ARG A O 1 ATOM 2726 C CB . ARG A 1 338 ? 28.152 42.377 -8.515 1.00 25.79 ? 338 ARG A CB 1 ATOM 2727 C CG . ARG A 1 338 ? 27.320 42.971 -7.385 1.00 25.72 ? 338 ARG A CG 1 ATOM 2728 C CD . ARG A 1 338 ? 26.720 41.904 -6.485 1.00 25.93 ? 338 ARG A CD 1 ATOM 2729 N NE . ARG A 1 338 ? 26.088 42.501 -5.312 1.00 24.88 ? 338 ARG A NE 1 ATOM 2730 C CZ . ARG A 1 338 ? 25.502 41.810 -4.339 1.00 25.00 ? 338 ARG A CZ 1 ATOM 2731 N NH1 . ARG A 1 338 ? 25.457 40.483 -4.395 1.00 22.83 ? 338 ARG A NH1 1 ATOM 2732 N NH2 . ARG A 1 338 ? 24.980 42.448 -3.295 1.00 23.82 ? 338 ARG A NH2 1 ATOM 2733 N N . GLN A 1 339 ? 30.897 43.354 -10.287 1.00 29.16 ? 339 GLN A N 1 ATOM 2734 C CA . GLN A 1 339 ? 32.033 42.901 -11.077 1.00 31.16 ? 339 GLN A CA 1 ATOM 2735 C C . GLN A 1 339 ? 32.914 41.973 -10.237 1.00 31.15 ? 339 GLN A C 1 ATOM 2736 O O . GLN A 1 339 ? 32.496 40.872 -9.884 1.00 30.47 ? 339 GLN A O 1 ATOM 2737 C CB . GLN A 1 339 ? 32.843 44.104 -11.566 1.00 34.76 ? 339 GLN A CB 1 ATOM 2738 C CG . GLN A 1 339 ? 32.051 45.072 -12.429 1.00 42.52 ? 339 GLN A CG 1 ATOM 2739 C CD . GLN A 1 339 ? 31.589 44.446 -13.739 1.00 49.72 ? 339 GLN A CD 1 ATOM 2740 O OE1 . GLN A 1 339 ? 32.368 44.314 -14.691 1.00 53.09 ? 339 GLN A OE1 1 ATOM 2741 N NE2 . GLN A 1 339 ? 30.319 44.044 -13.790 1.00 51.34 ? 339 GLN A NE2 1 ATOM 2742 N N . ASN A 1 340 ? 34.129 42.410 -9.913 1.00 31.12 ? 340 ASN A N 1 ATOM 2743 C CA . ASN A 1 340 ? 35.022 41.580 -9.108 1.00 30.58 ? 340 ASN A CA 1 ATOM 2744 C C . ASN A 1 340 ? 34.646 41.680 -7.634 1.00 30.66 ? 340 ASN A C 1 ATOM 2745 O O . ASN A 1 340 ? 34.076 42.680 -7.186 1.00 29.00 ? 340 ASN A O 1 ATOM 2746 C CB . ASN A 1 340 ? 36.488 41.987 -9.304 1.00 29.96 ? 340 ASN A CB 1 ATOM 2747 C CG . ASN A 1 340 ? 36.806 43.340 -8.706 1.00 30.68 ? 340 ASN A CG 1 ATOM 2748 O OD1 . ASN A 1 340 ? 36.310 44.367 -9.162 1.00 32.26 ? 340 ASN A OD1 1 ATOM 2749 N ND2 . ASN A 1 340 ? 37.641 43.345 -7.673 1.00 30.59 ? 340 ASN A ND2 1 ATOM 2750 N N . GLN A 1 341 ? 34.969 40.636 -6.882 1.00 30.03 ? 341 GLN A N 1 ATOM 2751 C CA . GLN A 1 341 ? 34.639 40.597 -5.471 1.00 29.08 ? 341 GLN A CA 1 ATOM 2752 C C . GLN A 1 341 ? 35.859 40.420 -4.574 1.00 28.96 ? 341 GLN A C 1 ATOM 2753 O O . GLN A 1 341 ? 36.802 39.708 -4.921 1.00 27.70 ? 341 GLN A O 1 ATOM 2754 C CB . GLN A 1 341 ? 33.655 39.451 -5.209 1.00 28.52 ? 341 GLN A CB 1 ATOM 2755 C CG . GLN A 1 341 ? 33.083 39.435 -3.804 1.00 33.08 ? 341 GLN A CG 1 ATOM 2756 C CD . GLN A 1 341 ? 32.326 38.157 -3.485 1.00 36.12 ? 341 GLN A CD 1 ATOM 2757 O OE1 . GLN A 1 341 ? 31.634 37.600 -4.338 1.00 39.23 ? 341 GLN A OE1 1 ATOM 2758 N NE2 . GLN A 1 341 ? 32.443 37.694 -2.245 1.00 37.66 ? 341 GLN A NE2 1 ATOM 2759 N N . VAL A 1 342 ? 35.832 41.092 -3.427 1.00 29.08 ? 342 VAL A N 1 ATOM 2760 C CA . VAL A 1 342 ? 36.887 40.987 -2.428 1.00 30.19 ? 342 VAL A CA 1 ATOM 2761 C C . VAL A 1 342 ? 36.138 40.571 -1.171 1.00 32.01 ? 342 VAL A C 1 ATOM 2762 O O . VAL A 1 342 ? 35.149 41.197 -0.792 1.00 32.34 ? 342 VAL A O 1 ATOM 2763 C CB . VAL A 1 342 ? 37.608 42.319 -2.197 1.00 30.02 ? 342 VAL A CB 1 ATOM 2764 C CG1 . VAL A 1 342 ? 38.566 42.189 -1.020 1.00 28.62 ? 342 VAL A CG1 1 ATOM 2765 C CG2 . VAL A 1 342 ? 38.380 42.703 -3.453 1.00 28.42 ? 342 VAL A CG2 1 ATOM 2766 N N . ASN A 1 343 ? 36.610 39.511 -0.528 1.00 33.14 ? 343 ASN A N 1 ATOM 2767 C CA . ASN A 1 343 ? 35.932 38.968 0.635 1.00 33.03 ? 343 ASN A CA 1 ATOM 2768 C C . ASN A 1 343 ? 36.851 38.771 1.844 1.00 32.83 ? 343 ASN A C 1 ATOM 2769 O O . ASN A 1 343 ? 38.042 38.501 1.691 1.00 32.25 ? 343 ASN A O 1 ATOM 2770 C CB . ASN A 1 343 ? 35.321 37.628 0.223 1.00 36.17 ? 343 ASN A CB 1 ATOM 2771 C CG . ASN A 1 343 ? 34.248 37.159 1.162 1.00 42.41 ? 343 ASN A CG 1 ATOM 2772 O OD1 . ASN A 1 343 ? 33.080 37.523 1.017 1.00 46.75 ? 343 ASN A OD1 1 ATOM 2773 N ND2 . ASN A 1 343 ? 34.632 36.346 2.143 1.00 45.29 ? 343 ASN A ND2 1 ATOM 2774 N N . LEU A 1 344 ? 36.292 38.918 3.043 1.00 31.05 ? 344 LEU A N 1 ATOM 2775 C CA . LEU A 1 344 ? 37.043 38.714 4.282 1.00 30.84 ? 344 LEU A CA 1 ATOM 2776 C C . LEU A 1 344 ? 36.204 37.858 5.221 1.00 30.74 ? 344 LEU A C 1 ATOM 2777 O O . LEU A 1 344 ? 34.982 37.968 5.243 1.00 31.51 ? 344 LEU A O 1 ATOM 2778 C CB . LEU A 1 344 ? 37.347 40.037 4.989 1.00 31.47 ? 344 LEU A CB 1 ATOM 2779 C CG . LEU A 1 344 ? 38.110 41.145 4.266 1.00 33.94 ? 344 LEU A CG 1 ATOM 2780 C CD1 . LEU A 1 344 ? 38.432 42.234 5.278 1.00 31.89 ? 344 LEU A CD1 1 ATOM 2781 C CD2 . LEU A 1 344 ? 39.388 40.608 3.633 1.00 33.63 ? 344 LEU A CD2 1 ATOM 2782 N N . GLN A 1 345 ? 36.855 37.004 5.998 1.00 31.12 ? 345 GLN A N 1 ATOM 2783 C CA . GLN A 1 345 ? 36.134 36.162 6.942 1.00 32.72 ? 345 GLN A CA 1 ATOM 2784 C C . GLN A 1 345 ? 36.941 35.893 8.195 1.00 32.09 ? 345 GLN A C 1 ATOM 2785 O O . GLN A 1 345 ? 38.168 35.814 8.150 1.00 31.89 ? 345 GLN A O 1 ATOM 2786 C CB . GLN A 1 345 ? 35.764 34.828 6.303 1.00 33.74 ? 345 GLN A CB 1 ATOM 2787 C CG . GLN A 1 345 ? 34.669 34.919 5.274 1.00 40.73 ? 345 GLN A CG 1 ATOM 2788 C CD . GLN A 1 345 ? 34.365 33.573 4.659 1.00 44.78 ? 345 GLN A CD 1 ATOM 2789 O OE1 . GLN A 1 345 ? 34.039 32.617 5.365 1.00 46.43 ? 345 GLN A OE1 1 ATOM 2790 N NE2 . GLN A 1 345 ? 34.476 33.487 3.335 1.00 46.39 ? 345 GLN A NE2 1 ATOM 2791 N N . ASN A 1 346 ? 36.236 35.759 9.314 1.00 31.85 ? 346 ASN A N 1 ATOM 2792 C CA . ASN A 1 346 ? 36.863 35.470 10.595 1.00 32.13 ? 346 ASN A CA 1 ATOM 2793 C C . ASN A 1 346 ? 38.049 36.394 10.874 1.00 31.20 ? 346 ASN A C 1 ATOM 2794 O O . ASN A 1 346 ? 39.138 35.936 11.220 1.00 31.12 ? 346 ASN A O 1 ATOM 2795 C CB . ASN A 1 346 ? 37.314 34.009 10.603 1.00 34.13 ? 346 ASN A CB 1 ATOM 2796 C CG . ASN A 1 346 ? 37.639 33.507 11.990 1.00 38.24 ? 346 ASN A CG 1 ATOM 2797 O OD1 . ASN A 1 346 ? 36.837 33.646 12.915 1.00 40.70 ? 346 ASN A OD1 1 ATOM 2798 N ND2 . ASN A 1 346 ? 38.815 32.905 12.143 1.00 39.18 ? 346 ASN A ND2 1 ATOM 2799 N N . LYS A 1 347 ? 37.828 37.696 10.727 1.00 29.60 ? 347 LYS A N 1 ATOM 2800 C CA . LYS A 1 347 ? 38.878 38.686 10.952 1.00 30.93 ? 347 LYS A CA 1 ATOM 2801 C C . LYS A 1 347 ? 38.610 39.567 12.172 1.00 32.23 ? 347 LYS A C 1 ATOM 2802 O O . LYS A 1 347 ? 37.579 40.236 12.255 1.00 32.12 ? 347 LYS A O 1 ATOM 2803 C CB . LYS A 1 347 ? 39.030 39.566 9.709 1.00 29.27 ? 347 LYS A CB 1 ATOM 2804 C CG . LYS A 1 347 ? 39.944 40.762 9.882 1.00 27.53 ? 347 LYS A CG 1 ATOM 2805 C CD . LYS A 1 347 ? 41.367 40.346 10.202 1.00 28.74 ? 347 LYS A CD 1 ATOM 2806 C CE . LYS A 1 347 ? 42.262 41.568 10.327 1.00 28.05 ? 347 LYS A CE 1 ATOM 2807 N NZ . LYS A 1 347 ? 43.656 41.198 10.676 1.00 29.79 ? 347 LYS A NZ 1 ATOM 2808 N N . ASN A 1 348 ? 39.548 39.564 13.113 1.00 33.52 ? 348 ASN A N 1 ATOM 2809 C CA . ASN A 1 348 ? 39.425 40.367 14.324 1.00 35.29 ? 348 ASN A CA 1 ATOM 2810 C C . ASN A 1 348 ? 39.830 41.814 14.112 1.00 34.47 ? 348 ASN A C 1 ATOM 2811 O O . ASN A 1 348 ? 40.795 42.103 13.408 1.00 34.36 ? 348 ASN A O 1 ATOM 2812 C CB . ASN A 1 348 ? 40.291 39.786 15.442 1.00 38.74 ? 348 ASN A CB 1 ATOM 2813 C CG . ASN A 1 348 ? 39.553 38.770 16.278 1.00 44.01 ? 348 ASN A CG 1 ATOM 2814 O OD1 . ASN A 1 348 ? 38.548 39.092 16.920 1.00 48.41 ? 348 ASN A OD1 1 ATOM 2815 N ND2 . ASN A 1 348 ? 40.043 37.532 16.278 1.00 46.66 ? 348 ASN A ND2 1 ATOM 2816 N N . LEU A 1 349 ? 39.083 42.724 14.725 1.00 33.96 ? 349 LEU A N 1 ATOM 2817 C CA . LEU A 1 349 ? 39.394 44.142 14.641 1.00 34.62 ? 349 LEU A CA 1 ATOM 2818 C C . LEU A 1 349 ? 39.743 44.608 16.047 1.00 35.37 ? 349 LEU A C 1 ATOM 2819 O O . LEU A 1 349 ? 38.862 44.765 16.891 1.00 35.42 ? 349 LEU A O 1 ATOM 2820 C CB . LEU A 1 349 ? 38.199 44.936 14.112 1.00 34.95 ? 349 LEU A CB 1 ATOM 2821 C CG . LEU A 1 349 ? 37.761 44.657 12.672 1.00 36.09 ? 349 LEU A CG 1 ATOM 2822 C CD1 . LEU A 1 349 ? 36.614 45.586 12.305 1.00 35.33 ? 349 LEU A CD1 1 ATOM 2823 C CD2 . LEU A 1 349 ? 38.934 44.862 11.724 1.00 35.39 ? 349 LEU A CD2 1 ATOM 2824 N N . LYS A 1 350 ? 41.032 44.808 16.302 1.00 36.47 ? 350 LYS A N 1 ATOM 2825 C CA . LYS A 1 350 ? 41.481 45.254 17.613 1.00 38.35 ? 350 LYS A CA 1 ATOM 2826 C C . LYS A 1 350 ? 41.016 46.680 17.867 1.00 36.78 ? 350 LYS A C 1 ATOM 2827 O O . LYS A 1 350 ? 40.744 47.430 16.929 1.00 37.43 ? 350 LYS A O 1 ATOM 2828 C CB . LYS A 1 350 ? 43.011 45.199 17.713 1.00 41.80 ? 350 LYS A CB 1 ATOM 2829 C CG . LYS A 1 350 ? 43.617 43.813 17.532 1.00 46.84 ? 350 LYS A CG 1 ATOM 2830 C CD . LYS A 1 350 ? 45.001 43.712 18.192 1.00 52.70 ? 350 LYS A CD 1 ATOM 2831 C CE . LYS A 1 350 ? 45.998 44.738 17.646 1.00 55.31 ? 350 LYS A CE 1 ATOM 2832 N NZ . LYS A 1 350 ? 46.367 44.482 16.221 1.00 59.49 ? 350 LYS A NZ 1 ATOM 2833 N N . PRO A 1 351 ? 40.919 47.076 19.145 1.00 34.90 ? 351 PRO A N 1 ATOM 2834 C CA . PRO A 1 351 ? 40.486 48.429 19.501 1.00 33.41 ? 351 PRO A CA 1 ATOM 2835 C C . PRO A 1 351 ? 41.324 49.503 18.810 1.00 32.13 ? 351 PRO A C 1 ATOM 2836 O O . PRO A 1 351 ? 42.546 49.423 18.794 1.00 32.64 ? 351 PRO A O 1 ATOM 2837 C CB . PRO A 1 351 ? 40.659 48.452 21.016 1.00 32.58 ? 351 PRO A CB 1 ATOM 2838 C CG . PRO A 1 351 ? 40.354 47.043 21.400 1.00 33.36 ? 351 PRO A CG 1 ATOM 2839 C CD . PRO A 1 351 ? 41.111 46.254 20.354 1.00 34.14 ? 351 PRO A CD 1 ATOM 2840 N N . GLY A 1 352 ? 40.657 50.498 18.234 1.00 31.65 ? 352 GLY A N 1 ATOM 2841 C CA . GLY A 1 352 ? 41.357 51.580 17.567 1.00 30.08 ? 352 GLY A CA 1 ATOM 2842 C C . GLY A 1 352 ? 42.038 51.197 16.269 1.00 31.10 ? 352 GLY A C 1 ATOM 2843 O O . GLY A 1 352 ? 42.954 51.892 15.820 1.00 32.30 ? 352 GLY A O 1 ATOM 2844 N N . SER A 1 353 ? 41.595 50.108 15.649 1.00 29.57 ? 353 SER A N 1 ATOM 2845 C CA . SER A 1 353 ? 42.205 49.666 14.400 1.00 29.59 ? 353 SER A CA 1 ATOM 2846 C C . SER A 1 353 ? 41.426 50.084 13.155 1.00 29.55 ? 353 SER A C 1 ATOM 2847 O O . SER A 1 353 ? 40.216 50.320 13.202 1.00 28.54 ? 353 SER A O 1 ATOM 2848 C CB . SER A 1 353 ? 42.364 48.143 14.398 1.00 29.76 ? 353 SER A CB 1 ATOM 2849 O OG . SER A 1 353 ? 41.103 47.497 14.322 1.00 29.68 ? 353 SER A OG 1 ATOM 2850 N N . VAL A 1 354 ? 42.148 50.163 12.041 1.00 28.98 ? 354 VAL A N 1 ATOM 2851 C CA . VAL A 1 354 ? 41.583 50.522 10.745 1.00 28.17 ? 354 VAL A CA 1 ATOM 2852 C C . VAL A 1 354 ? 42.149 49.535 9.728 1.00 28.38 ? 354 VAL A C 1 ATOM 2853 O O . VAL A 1 354 ? 43.365 49.395 9.596 1.00 29.37 ? 354 VAL A O 1 ATOM 2854 C CB . VAL A 1 354 ? 41.979 51.960 10.337 1.00 27.80 ? 354 VAL A CB 1 ATOM 2855 C CG1 . VAL A 1 354 ? 41.497 52.252 8.925 1.00 26.75 ? 354 VAL A CG1 1 ATOM 2856 C CG2 . VAL A 1 354 ? 41.382 52.963 11.325 1.00 25.42 ? 354 VAL A CG2 1 ATOM 2857 N N . LEU A 1 355 ? 41.265 48.846 9.017 1.00 27.28 ? 355 LEU A N 1 ATOM 2858 C CA . LEU A 1 355 ? 41.679 47.851 8.033 1.00 26.64 ? 355 LEU A CA 1 ATOM 2859 C C . LEU A 1 355 ? 41.244 48.244 6.628 1.00 27.37 ? 355 LEU A C 1 ATOM 2860 O O . LEU A 1 355 ? 40.049 48.333 6.348 1.00 29.09 ? 355 LEU A O 1 ATOM 2861 C CB . LEU A 1 355 ? 41.071 46.495 8.398 1.00 25.46 ? 355 LEU A CB 1 ATOM 2862 C CG . LEU A 1 355 ? 41.294 45.314 7.456 1.00 26.03 ? 355 LEU A CG 1 ATOM 2863 C CD1 . LEU A 1 355 ? 42.776 44.955 7.414 1.00 24.62 ? 355 LEU A CD1 1 ATOM 2864 C CD2 . LEU A 1 355 ? 40.464 44.131 7.940 1.00 24.74 ? 355 LEU A CD2 1 ATOM 2865 N N . GLU A 1 356 ? 42.204 48.469 5.738 1.00 26.02 ? 356 GLU A N 1 ATOM 2866 C CA . GLU A 1 356 ? 41.852 48.852 4.380 1.00 26.64 ? 356 GLU A CA 1 ATOM 2867 C C . GLU A 1 356 ? 41.463 47.671 3.504 1.00 26.96 ? 356 GLU A C 1 ATOM 2868 O O . GLU A 1 356 ? 42.070 46.602 3.565 1.00 28.43 ? 356 GLU A O 1 ATOM 2869 C CB . GLU A 1 356 ? 42.989 49.618 3.700 1.00 24.94 ? 356 GLU A CB 1 ATOM 2870 C CG . GLU A 1 356 ? 42.623 50.019 2.275 1.00 28.05 ? 356 GLU A CG 1 ATOM 2871 C CD . GLU A 1 356 ? 43.603 50.982 1.628 1.00 30.34 ? 356 GLU A CD 1 ATOM 2872 O OE1 . GLU A 1 356 ? 44.632 51.321 2.250 1.00 31.77 ? 356 GLU A OE1 1 ATOM 2873 O OE2 . GLU A 1 356 ? 43.334 51.401 0.482 1.00 31.32 ? 356 GLU A OE2 1 ATOM 2874 N N . ILE A 1 357 ? 40.437 47.878 2.689 1.00 25.87 ? 357 ILE A N 1 ATOM 2875 C CA . ILE A 1 357 ? 39.970 46.858 1.771 1.00 25.62 ? 357 ILE A CA 1 ATOM 2876 C C . ILE A 1 357 ? 40.528 47.218 0.400 1.00 26.11 ? 357 ILE A C 1 ATOM 2877 O O . ILE A 1 357 ? 40.192 48.261 -0.159 1.00 27.22 ? 357 ILE A O 1 ATOM 2878 C CB . ILE A 1 357 ? 38.436 46.828 1.736 1.00 25.69 ? 357 ILE A CB 1 ATOM 2879 C CG1 . ILE A 1 357 ? 37.915 46.380 3.102 1.00 25.07 ? 357 ILE A CG1 1 ATOM 2880 C CG2 . ILE A 1 357 ? 37.947 45.894 0.633 1.00 21.35 ? 357 ILE A CG2 1 ATOM 2881 C CD1 . ILE A 1 357 ? 36.414 46.467 3.234 1.00 29.81 ? 357 ILE A CD1 1 ATOM 2882 N N . HIS A 1 358 ? 41.389 46.352 -0.126 1.00 26.91 ? 358 HIS A N 1 ATOM 2883 C CA . HIS A 1 358 ? 42.038 46.573 -1.419 1.00 27.49 ? 358 HIS A CA 1 ATOM 2884 C C . HIS A 1 358 ? 41.365 45.860 -2.583 1.00 27.41 ? 358 HIS A C 1 ATOM 2885 O O . HIS A 1 358 ? 40.677 44.857 -2.394 1.00 26.95 ? 358 HIS A O 1 ATOM 2886 C CB . HIS A 1 358 ? 43.492 46.100 -1.349 1.00 27.03 ? 358 HIS A CB 1 ATOM 2887 C CG . HIS A 1 358 ? 44.323 46.839 -0.348 1.00 28.36 ? 358 HIS A CG 1 ATOM 2888 N ND1 . HIS A 1 358 ? 45.045 47.969 -0.669 1.00 29.56 ? 358 HIS A ND1 1 ATOM 2889 C CD2 . HIS A 1 358 ? 44.550 46.607 0.966 1.00 27.29 ? 358 HIS A CD2 1 ATOM 2890 C CE1 . HIS A 1 358 ? 45.684 48.398 0.405 1.00 29.44 ? 358 HIS A CE1 1 ATOM 2891 N NE2 . HIS A 1 358 ? 45.401 47.589 1.410 1.00 28.29 ? 358 HIS A NE2 1 ATOM 2892 N N . GLY A 1 359 ? 41.576 46.390 -3.788 1.00 28.05 ? 359 GLY A N 1 ATOM 2893 C CA . GLY A 1 359 ? 41.033 45.771 -4.987 1.00 28.54 ? 359 GLY A CA 1 ATOM 2894 C C . GLY A 1 359 ? 39.626 46.127 -5.426 1.00 28.77 ? 359 GLY A C 1 ATOM 2895 O O . GLY A 1 359 ? 39.128 45.570 -6.403 1.00 29.41 ? 359 GLY A O 1 ATOM 2896 N N . ILE A 1 360 ? 38.990 47.057 -4.726 1.00 28.35 ? 360 ILE A N 1 ATOM 2897 C CA . ILE A 1 360 ? 37.627 47.465 -5.050 1.00 28.09 ? 360 ILE A CA 1 ATOM 2898 C C . ILE A 1 360 ? 37.586 48.899 -5.561 1.00 27.25 ? 360 ILE A C 1 ATOM 2899 O O . ILE A 1 360 ? 38.403 49.723 -5.158 1.00 28.09 ? 360 ILE A O 1 ATOM 2900 C CB . ILE A 1 360 ? 36.723 47.367 -3.786 1.00 29.27 ? 360 ILE A CB 1 ATOM 2901 C CG1 . ILE A 1 360 ? 36.564 45.903 -3.378 1.00 30.48 ? 360 ILE A CG1 1 ATOM 2902 C CG2 . ILE A 1 360 ? 35.375 48.011 -4.036 1.00 27.68 ? 360 ILE A CG2 1 ATOM 2903 C CD1 . ILE A 1 360 ? 35.935 45.029 -4.457 1.00 31.14 ? 360 ILE A CD1 1 ATOM 2904 N N . ALA A 1 361 ? 36.652 49.189 -6.464 1.00 25.45 ? 361 ALA A N 1 ATOM 2905 C CA . ALA A 1 361 ? 36.482 50.550 -6.971 1.00 24.58 ? 361 ALA A CA 1 ATOM 2906 C C . ALA A 1 361 ? 35.715 51.240 -5.841 1.00 24.06 ? 361 ALA A C 1 ATOM 2907 O O . ALA A 1 361 ? 34.484 51.271 -5.838 1.00 23.77 ? 361 ALA A O 1 ATOM 2908 C CB . ALA A 1 361 ? 35.653 50.539 -8.249 1.00 24.06 ? 361 ALA A CB 1 ATOM 2909 N N . ALA A 1 362 ? 36.463 51.768 -4.879 1.00 23.83 ? 362 ALA A N 1 ATOM 2910 C CA . ALA A 1 362 ? 35.917 52.413 -3.683 1.00 24.04 ? 362 ALA A CA 1 ATOM 2911 C C . ALA A 1 362 ? 34.836 53.484 -3.837 1.00 23.60 ? 362 ALA A C 1 ATOM 2912 O O . ALA A 1 362 ? 34.103 53.749 -2.886 1.00 22.36 ? 362 ALA A O 1 ATOM 2913 C CB . ALA A 1 362 ? 37.070 52.964 -2.839 1.00 24.09 ? 362 ALA A CB 1 ATOM 2914 N N . SER A 1 363 ? 34.737 54.106 -5.009 1.00 23.66 ? 363 SER A N 1 ATOM 2915 C CA . SER A 1 363 ? 33.723 55.142 -5.234 1.00 25.49 ? 363 SER A CA 1 ATOM 2916 C C . SER A 1 363 ? 32.417 54.569 -5.780 1.00 25.99 ? 363 SER A C 1 ATOM 2917 O O . SER A 1 363 ? 31.385 55.245 -5.787 1.00 27.35 ? 363 SER A O 1 ATOM 2918 C CB . SER A 1 363 ? 34.226 56.193 -6.234 1.00 25.50 ? 363 SER A CB 1 ATOM 2919 O OG . SER A 1 363 ? 35.214 57.039 -5.677 1.00 30.92 ? 363 SER A OG 1 ATOM 2920 N N . GLN A 1 364 ? 32.462 53.325 -6.240 1.00 24.70 ? 364 GLN A N 1 ATOM 2921 C CA . GLN A 1 364 ? 31.289 52.694 -6.833 1.00 24.72 ? 364 GLN A CA 1 ATOM 2922 C C . GLN A 1 364 ? 31.276 51.215 -6.448 1.00 24.21 ? 364 GLN A C 1 ATOM 2923 O O . GLN A 1 364 ? 31.735 50.360 -7.207 1.00 25.47 ? 364 GLN A O 1 ATOM 2924 C CB . GLN A 1 364 ? 31.376 52.867 -8.353 1.00 22.69 ? 364 GLN A CB 1 ATOM 2925 C CG . GLN A 1 364 ? 30.065 52.785 -9.089 1.00 24.10 ? 364 GLN A CG 1 ATOM 2926 C CD . GLN A 1 364 ? 30.182 53.306 -10.509 1.00 23.77 ? 364 GLN A CD 1 ATOM 2927 O OE1 . GLN A 1 364 ? 30.527 54.470 -10.730 1.00 21.79 ? 364 GLN A OE1 1 ATOM 2928 N NE2 . GLN A 1 364 ? 29.892 52.448 -11.479 1.00 23.69 ? 364 GLN A NE2 1 ATOM 2929 N N . ALA A 1 365 ? 30.732 50.916 -5.271 1.00 23.20 ? 365 ALA A N 1 ATOM 2930 C CA . ALA A 1 365 ? 30.723 49.547 -4.781 1.00 20.75 ? 365 ALA A CA 1 ATOM 2931 C C . ALA A 1 365 ? 29.505 49.152 -3.955 1.00 21.64 ? 365 ALA A C 1 ATOM 2932 O O . ALA A 1 365 ? 28.717 49.991 -3.526 1.00 20.90 ? 365 ALA A O 1 ATOM 2933 C CB . ALA A 1 365 ? 31.980 49.312 -3.964 1.00 17.80 ? 365 ALA A CB 1 ATOM 2934 N N . ASP A 1 366 ? 29.377 47.847 -3.743 1.00 22.36 ? 366 ASP A N 1 ATOM 2935 C CA . ASP A 1 366 ? 28.300 47.260 -2.960 1.00 23.30 ? 366 ASP A CA 1 ATOM 2936 C C . ASP A 1 366 ? 29.057 46.499 -1.870 1.00 25.11 ? 366 ASP A C 1 ATOM 2937 O O . ASP A 1 366 ? 29.711 45.492 -2.145 1.00 26.77 ? 366 ASP A O 1 ATOM 2938 C CB . ASP A 1 366 ? 27.491 46.292 -3.824 1.00 22.26 ? 366 ASP A CB 1 ATOM 2939 C CG . ASP A 1 366 ? 26.192 45.860 -3.168 1.00 23.87 ? 366 ASP A CG 1 ATOM 2940 O OD1 . ASP A 1 366 ? 26.028 46.047 -1.942 1.00 22.70 ? 366 ASP A OD1 1 ATOM 2941 O OD2 . ASP A 1 366 ? 25.328 45.318 -3.888 1.00 25.53 ? 366 ASP A OD2 1 ATOM 2942 N N . VAL A 1 367 ? 28.980 46.990 -0.639 1.00 25.55 ? 367 VAL A N 1 ATOM 2943 C CA . VAL A 1 367 ? 29.699 46.375 0.465 1.00 25.21 ? 367 VAL A CA 1 ATOM 2944 C C . VAL A 1 367 ? 28.796 45.879 1.586 1.00 26.85 ? 367 VAL A C 1 ATOM 2945 O O . VAL A 1 367 ? 27.952 46.618 2.098 1.00 27.28 ? 367 VAL A O 1 ATOM 2946 C CB . VAL A 1 367 ? 30.720 47.367 1.062 1.00 24.16 ? 367 VAL A CB 1 ATOM 2947 C CG1 . VAL A 1 367 ? 31.560 46.678 2.120 1.00 23.48 ? 367 VAL A CG1 1 ATOM 2948 C CG2 . VAL A 1 367 ? 31.599 47.930 -0.043 1.00 22.97 ? 367 VAL A CG2 1 ATOM 2949 N N . THR A 1 368 ? 28.988 44.619 1.961 1.00 26.52 ? 368 THR A N 1 ATOM 2950 C CA . THR A 1 368 ? 28.218 44.007 3.028 1.00 27.59 ? 368 THR A CA 1 ATOM 2951 C C . THR A 1 368 ? 29.181 43.470 4.073 1.00 27.70 ? 368 THR A C 1 ATOM 2952 O O . THR A 1 368 ? 30.194 42.856 3.745 1.00 27.10 ? 368 THR A O 1 ATOM 2953 C CB . THR A 1 368 ? 27.359 42.844 2.514 1.00 28.79 ? 368 THR A CB 1 ATOM 2954 O OG1 . THR A 1 368 ? 26.397 43.341 1.576 1.00 32.23 ? 368 THR A OG1 1 ATOM 2955 C CG2 . THR A 1 368 ? 26.629 42.177 3.670 1.00 31.00 ? 368 THR A CG2 1 ATOM 2956 N N . ILE A 1 369 ? 28.860 43.708 5.335 1.00 27.75 ? 369 ILE A N 1 ATOM 2957 C CA . ILE A 1 369 ? 29.708 43.247 6.410 1.00 28.78 ? 369 ILE A CA 1 ATOM 2958 C C . ILE A 1 369 ? 28.850 42.813 7.586 1.00 28.71 ? 369 ILE A C 1 ATOM 2959 O O . ILE A 1 369 ? 27.768 43.351 7.816 1.00 29.14 ? 369 ILE A O 1 ATOM 2960 C CB . ILE A 1 369 ? 30.691 44.352 6.830 1.00 29.65 ? 369 ILE A CB 1 ATOM 2961 C CG1 . ILE A 1 369 ? 31.667 43.813 7.872 1.00 31.24 ? 369 ILE A CG1 1 ATOM 2962 C CG2 . ILE A 1 369 ? 29.928 45.556 7.343 1.00 29.96 ? 369 ILE A CG2 1 ATOM 2963 C CD1 . ILE A 1 369 ? 32.828 44.749 8.144 1.00 34.64 ? 369 ILE A CD1 1 ATOM 2964 N N . SER A 1 370 ? 29.333 41.819 8.318 1.00 29.16 ? 370 SER A N 1 ATOM 2965 C CA . SER A 1 370 ? 28.608 41.289 9.461 1.00 28.44 ? 370 SER A CA 1 ATOM 2966 C C . SER A 1 370 ? 29.577 41.206 10.638 1.00 28.05 ? 370 SER A C 1 ATOM 2967 O O . SER A 1 370 ? 30.692 40.703 10.501 1.00 27.99 ? 370 SER A O 1 ATOM 2968 C CB . SER A 1 370 ? 28.061 39.908 9.106 1.00 28.62 ? 370 SER A CB 1 ATOM 2969 O OG . SER A 1 370 ? 26.984 39.548 9.945 1.00 34.43 ? 370 SER A OG 1 ATOM 2970 N N . PHE A 1 371 ? 29.150 41.707 11.793 1.00 28.36 ? 371 PHE A N 1 ATOM 2971 C CA . PHE A 1 371 ? 29.991 41.712 12.986 1.00 28.49 ? 371 PHE A CA 1 ATOM 2972 C C . PHE A 1 371 ? 29.542 40.710 14.039 1.00 30.82 ? 371 PHE A C 1 ATOM 2973 O O . PHE A 1 371 ? 28.350 40.572 14.309 1.00 31.75 ? 371 PHE A O 1 ATOM 2974 C CB . PHE A 1 371 ? 29.987 43.103 13.623 1.00 27.47 ? 371 PHE A CB 1 ATOM 2975 C CG . PHE A 1 371 ? 30.558 44.178 12.750 1.00 26.80 ? 371 PHE A CG 1 ATOM 2976 C CD1 . PHE A 1 371 ? 31.934 44.374 12.676 1.00 25.19 ? 371 PHE A CD1 1 ATOM 2977 C CD2 . PHE A 1 371 ? 29.719 44.999 11.998 1.00 25.70 ? 371 PHE A CD2 1 ATOM 2978 C CE1 . PHE A 1 371 ? 32.471 45.373 11.869 1.00 26.76 ? 371 PHE A CE1 1 ATOM 2979 C CE2 . PHE A 1 371 ? 30.244 46.000 11.184 1.00 26.91 ? 371 PHE A CE2 1 ATOM 2980 C CZ . PHE A 1 371 ? 31.623 46.190 11.119 1.00 27.04 ? 371 PHE A CZ 1 ATOM 2981 N N . LYS A 1 372 ? 30.510 40.020 14.637 1.00 32.88 ? 372 LYS A N 1 ATOM 2982 C CA . LYS A 1 372 ? 30.246 39.055 15.702 1.00 36.38 ? 372 LYS A CA 1 ATOM 2983 C C . LYS A 1 372 ? 30.797 39.717 16.966 1.00 36.92 ? 372 LYS A C 1 ATOM 2984 O O . LYS A 1 372 ? 31.998 39.971 17.063 1.00 35.84 ? 372 LYS A O 1 ATOM 2985 C CB . LYS A 1 372 ? 30.983 37.745 15.425 1.00 39.70 ? 372 LYS A CB 1 ATOM 2986 C CG . LYS A 1 372 ? 30.718 36.654 16.442 1.00 42.64 ? 372 LYS A CG 1 ATOM 2987 C CD . LYS A 1 372 ? 31.543 35.416 16.135 1.00 47.15 ? 372 LYS A CD 1 ATOM 2988 C CE . LYS A 1 372 ? 31.294 34.317 17.158 1.00 50.47 ? 372 LYS A CE 1 ATOM 2989 N NZ . LYS A 1 372 ? 32.142 33.112 16.904 1.00 53.85 ? 372 LYS A NZ 1 ATOM 2990 N N . LEU A 1 373 ? 29.923 39.997 17.928 1.00 39.23 ? 373 LEU A N 1 ATOM 2991 C CA . LEU A 1 373 ? 30.331 40.687 19.149 1.00 42.50 ? 373 LEU A CA 1 ATOM 2992 C C . LEU A 1 373 ? 30.930 39.876 20.290 1.00 45.44 ? 373 LEU A C 1 ATOM 2993 O O . LEU A 1 373 ? 30.480 38.774 20.613 1.00 44.47 ? 373 LEU A O 1 ATOM 2994 C CB . LEU A 1 373 ? 29.165 41.521 19.682 1.00 40.99 ? 373 LEU A CB 1 ATOM 2995 C CG . LEU A 1 373 ? 28.715 42.628 18.729 1.00 41.18 ? 373 LEU A CG 1 ATOM 2996 C CD1 . LEU A 1 373 ? 27.642 43.466 19.393 1.00 41.98 ? 373 LEU A CD1 1 ATOM 2997 C CD2 . LEU A 1 373 ? 29.909 43.493 18.350 1.00 41.84 ? 373 LEU A CD2 1 ATOM 2998 N N . GLU A 1 374 ? 31.948 40.469 20.906 1.00 49.52 ? 374 GLU A N 1 ATOM 2999 C CA . GLU A 1 374 ? 32.670 39.867 22.018 1.00 52.55 ? 374 GLU A CA 1 ATOM 3000 C C . GLU A 1 374 ? 32.418 40.606 23.332 1.00 51.89 ? 374 GLU A C 1 ATOM 3001 O O . GLU A 1 374 ? 32.711 41.802 23.450 1.00 52.33 ? 374 GLU A O 1 ATOM 3002 C CB . GLU A 1 374 ? 34.174 39.874 21.716 1.00 56.56 ? 374 GLU A CB 1 ATOM 3003 C CG . GLU A 1 374 ? 35.052 39.418 22.873 1.00 60.93 ? 374 GLU A CG 1 ATOM 3004 C CD . GLU A 1 374 ? 36.532 39.443 22.531 1.00 64.29 ? 374 GLU A CD 1 ATOM 3005 O OE1 . GLU A 1 374 ? 36.932 38.751 21.567 1.00 64.42 ? 374 GLU A OE1 1 ATOM 3006 O OE2 . GLU A 1 374 ? 37.292 40.153 23.229 1.00 65.28 ? 374 GLU A OE2 1 ATOM 3007 N N . GLY A 1 375 ? 31.877 39.887 24.312 1.00 49.57 ? 375 GLY A N 1 ATOM 3008 C CA . GLY A 1 375 ? 31.621 40.475 25.616 1.00 46.77 ? 375 GLY A CA 1 ATOM 3009 C C . GLY A 1 375 ? 30.571 41.568 25.656 1.00 44.69 ? 375 GLY A C 1 ATOM 3010 O O . GLY A 1 375 ? 30.879 42.720 25.961 1.00 43.77 ? 375 GLY A O 1 ATOM 3011 N N . LEU A 1 376 ? 29.327 41.202 25.364 1.00 42.50 ? 376 LEU A N 1 ATOM 3012 C CA . LEU A 1 376 ? 28.221 42.149 25.369 1.00 42.02 ? 376 LEU A CA 1 ATOM 3013 C C . LEU A 1 376 ? 28.022 42.834 26.712 1.00 42.16 ? 376 LEU A C 1 ATOM 3014 O O . LEU A 1 376 ? 27.706 44.023 26.767 1.00 42.68 ? 376 LEU A O 1 ATOM 3015 C CB . LEU A 1 376 ? 26.918 41.447 24.984 1.00 40.63 ? 376 LEU A CB 1 ATOM 3016 C CG . LEU A 1 376 ? 26.720 41.081 23.518 1.00 40.27 ? 376 LEU A CG 1 ATOM 3017 C CD1 . LEU A 1 376 ? 25.396 40.356 23.355 1.00 40.17 ? 376 LEU A CD1 1 ATOM 3018 C CD2 . LEU A 1 376 ? 26.744 42.344 22.670 1.00 40.46 ? 376 LEU A CD2 1 ATOM 3019 N N . LYS A 1 377 ? 28.205 42.086 27.795 1.00 41.64 ? 377 LYS A N 1 ATOM 3020 C CA . LYS A 1 377 ? 28.009 42.639 29.127 1.00 41.89 ? 377 LYS A CA 1 ATOM 3021 C C . LYS A 1 377 ? 28.858 43.878 29.382 1.00 39.51 ? 377 LYS A C 1 ATOM 3022 O O . LYS A 1 377 ? 28.601 44.620 30.327 1.00 39.69 ? 377 LYS A O 1 ATOM 3023 C CB . LYS A 1 377 ? 28.298 41.581 30.194 1.00 45.18 ? 377 LYS A CB 1 ATOM 3024 C CG . LYS A 1 377 ? 29.755 41.163 30.284 1.00 51.68 ? 377 LYS A CG 1 ATOM 3025 C CD . LYS A 1 377 ? 29.973 40.225 31.462 1.00 55.14 ? 377 LYS A CD 1 ATOM 3026 C CE . LYS A 1 377 ? 31.449 39.929 31.678 1.00 57.49 ? 377 LYS A CE 1 ATOM 3027 N NZ . LYS A 1 377 ? 31.648 39.042 32.860 1.00 59.27 ? 377 LYS A NZ 1 ATOM 3028 N N . GLU A 1 378 ? 29.861 44.106 28.538 1.00 37.13 ? 378 GLU A N 1 ATOM 3029 C CA . GLU A 1 378 ? 30.733 45.268 28.691 1.00 35.42 ? 378 GLU A CA 1 ATOM 3030 C C . GLU A 1 378 ? 30.117 46.521 28.079 1.00 33.92 ? 378 GLU A C 1 ATOM 3031 O O . GLU A 1 378 ? 30.673 47.614 28.188 1.00 32.28 ? 378 GLU A O 1 ATOM 3032 C CB . GLU A 1 378 ? 32.095 45.005 28.045 1.00 37.65 ? 378 GLU A CB 1 ATOM 3033 C CG . GLU A 1 378 ? 32.871 43.859 28.678 1.00 40.21 ? 378 GLU A CG 1 ATOM 3034 C CD . GLU A 1 378 ? 32.923 43.963 30.190 1.00 42.30 ? 378 GLU A CD 1 ATOM 3035 O OE1 . GLU A 1 378 ? 33.341 45.025 30.705 1.00 43.92 ? 378 GLU A OE1 1 ATOM 3036 O OE2 . GLU A 1 378 ? 32.546 42.982 30.863 1.00 44.70 ? 378 GLU A OE2 1 ATOM 3037 N N . ALA A 1 379 ? 28.964 46.358 27.438 1.00 31.72 ? 379 ALA A N 1 ATOM 3038 C CA . ALA A 1 379 ? 28.281 47.479 26.810 1.00 31.54 ? 379 ALA A CA 1 ATOM 3039 C C . ALA A 1 379 ? 28.030 48.620 27.798 1.00 31.77 ? 379 ALA A C 1 ATOM 3040 O O . ALA A 1 379 ? 27.643 48.395 28.950 1.00 31.41 ? 379 ALA A O 1 ATOM 3041 C CB . ALA A 1 379 ? 26.963 47.012 26.206 1.00 29.77 ? 379 ALA A CB 1 ATOM 3042 N N . GLU A 1 380 ? 28.271 49.843 27.336 1.00 30.37 ? 380 GLU A N 1 ATOM 3043 C CA . GLU A 1 380 ? 28.057 51.035 28.142 1.00 29.59 ? 380 GLU A CA 1 ATOM 3044 C C . GLU A 1 380 ? 26.607 51.041 28.590 1.00 30.43 ? 380 GLU A C 1 ATOM 3045 O O . GLU A 1 380 ? 25.717 50.695 27.816 1.00 31.22 ? 380 GLU A O 1 ATOM 3046 C CB . GLU A 1 380 ? 28.315 52.288 27.307 1.00 29.57 ? 380 GLU A CB 1 ATOM 3047 C CG . GLU A 1 380 ? 29.768 52.563 26.982 1.00 28.71 ? 380 GLU A CG 1 ATOM 3048 C CD . GLU A 1 380 ? 29.927 53.348 25.691 1.00 30.64 ? 380 GLU A CD 1 ATOM 3049 O OE1 . GLU A 1 380 ? 30.062 52.714 24.623 1.00 29.42 ? 380 GLU A OE1 1 ATOM 3050 O OE2 . GLU A 1 380 ? 29.905 54.596 25.738 1.00 32.09 ? 380 GLU A OE2 1 ATOM 3051 N N . VAL A 1 381 ? 26.363 51.426 29.837 1.00 30.57 ? 381 VAL A N 1 ATOM 3052 C CA . VAL A 1 381 ? 24.995 51.478 30.324 1.00 31.35 ? 381 VAL A CA 1 ATOM 3053 C C . VAL A 1 381 ? 24.381 52.800 29.892 1.00 30.67 ? 381 VAL A C 1 ATOM 3054 O O . VAL A 1 381 ? 24.886 53.876 30.220 1.00 31.84 ? 381 VAL A O 1 ATOM 3055 C CB . VAL A 1 381 ? 24.929 51.358 31.857 1.00 33.22 ? 381 VAL A CB 1 ATOM 3056 C CG1 . VAL A 1 381 ? 25.361 49.965 32.284 1.00 31.69 ? 381 VAL A CG1 1 ATOM 3057 C CG2 . VAL A 1 381 ? 25.832 52.396 32.495 1.00 39.58 ? 381 VAL A CG2 1 ATOM 3058 N N . LEU A 1 382 ? 23.302 52.714 29.128 1.00 28.55 ? 382 LEU A N 1 ATOM 3059 C CA . LEU A 1 382 ? 22.619 53.902 28.652 1.00 27.96 ? 382 LEU A CA 1 ATOM 3060 C C . LEU A 1 382 ? 21.197 53.544 28.279 1.00 28.51 ? 382 LEU A C 1 ATOM 3061 O O . LEU A 1 382 ? 20.968 52.809 27.316 1.00 30.05 ? 382 LEU A O 1 ATOM 3062 C CB . LEU A 1 382 ? 23.328 54.483 27.423 1.00 27.83 ? 382 LEU A CB 1 ATOM 3063 C CG . LEU A 1 382 ? 22.610 55.655 26.737 1.00 28.35 ? 382 LEU A CG 1 ATOM 3064 C CD1 . LEU A 1 382 ? 22.653 56.870 27.652 1.00 28.09 ? 382 LEU A CD1 1 ATOM 3065 C CD2 . LEU A 1 382 ? 23.262 55.974 25.394 1.00 25.54 ? 382 LEU A CD2 1 ATOM 3066 N N . ASP A 1 383 ? 20.241 54.047 29.049 1.00 27.95 ? 383 ASP A N 1 ATOM 3067 C CA . ASP A 1 383 ? 18.842 53.791 28.749 1.00 27.02 ? 383 ASP A CA 1 ATOM 3068 C C . ASP A 1 383 ? 18.548 54.678 27.540 1.00 26.77 ? 383 ASP A C 1 ATOM 3069 O O . ASP A 1 383 ? 18.869 55.866 27.548 1.00 25.91 ? 383 ASP A O 1 ATOM 3070 C CB . ASP A 1 383 ? 17.959 54.199 29.923 1.00 26.61 ? 383 ASP A CB 1 ATOM 3071 C CG . ASP A 1 383 ? 16.538 53.718 29.765 1.00 26.81 ? 383 ASP A CG 1 ATOM 3072 O OD1 . ASP A 1 383 ? 16.189 52.676 30.361 1.00 25.83 ? 383 ASP A OD1 1 ATOM 3073 O OD2 . ASP A 1 383 ? 15.775 54.374 29.027 1.00 26.83 ? 383 ASP A OD2 1 ATOM 3074 N N . THR A 1 384 ? 17.951 54.108 26.501 1.00 26.46 ? 384 THR A N 1 ATOM 3075 C CA . THR A 1 384 ? 17.670 54.873 25.293 1.00 27.52 ? 384 THR A CA 1 ATOM 3076 C C . THR A 1 384 ? 16.183 55.031 24.996 1.00 27.53 ? 384 THR A C 1 ATOM 3077 O O . THR A 1 384 ? 15.785 55.253 23.851 1.00 27.02 ? 384 THR A O 1 ATOM 3078 C CB . THR A 1 384 ? 18.365 54.226 24.077 1.00 28.42 ? 384 THR A CB 1 ATOM 3079 O OG1 . THR A 1 384 ? 18.042 52.832 24.035 1.00 29.64 ? 384 THR A OG1 1 ATOM 3080 C CG2 . THR A 1 384 ? 19.878 54.381 24.180 1.00 26.47 ? 384 THR A CG2 1 ATOM 3081 N N . THR A 1 385 ? 15.366 54.938 26.038 1.00 27.15 ? 385 THR A N 1 ATOM 3082 C CA . THR A 1 385 ? 13.923 55.066 25.893 1.00 26.12 ? 385 THR A CA 1 ATOM 3083 C C . THR A 1 385 ? 13.478 56.355 25.192 1.00 25.43 ? 385 THR A C 1 ATOM 3084 O O . THR A 1 385 ? 12.637 56.316 24.294 1.00 25.52 ? 385 THR A O 1 ATOM 3085 C CB . THR A 1 385 ? 13.237 54.987 27.269 1.00 27.39 ? 385 THR A CB 1 ATOM 3086 O OG1 . THR A 1 385 ? 13.616 53.769 27.922 1.00 28.10 ? 385 THR A OG1 1 ATOM 3087 C CG2 . THR A 1 385 ? 11.724 55.014 27.114 1.00 26.86 ? 385 THR A CG2 1 ATOM 3088 N N . LEU A 1 386 ? 14.042 57.492 25.594 1.00 24.04 ? 386 LEU A N 1 ATOM 3089 C CA . LEU A 1 386 ? 13.666 58.777 25.007 1.00 24.22 ? 386 LEU A CA 1 ATOM 3090 C C . LEU A 1 386 ? 14.800 59.435 24.231 1.00 24.56 ? 386 LEU A C 1 ATOM 3091 O O . LEU A 1 386 ? 14.651 60.547 23.720 1.00 22.88 ? 386 LEU A O 1 ATOM 3092 C CB . LEU A 1 386 ? 13.203 59.739 26.106 1.00 22.81 ? 386 LEU A CB 1 ATOM 3093 C CG . LEU A 1 386 ? 12.138 59.214 27.070 1.00 24.82 ? 386 LEU A CG 1 ATOM 3094 C CD1 . LEU A 1 386 ? 11.870 60.255 28.147 1.00 24.59 ? 386 LEU A CD1 1 ATOM 3095 C CD2 . LEU A 1 386 ? 10.867 58.883 26.303 1.00 23.36 ? 386 LEU A CD2 1 ATOM 3096 N N . VAL A 1 387 ? 15.936 58.754 24.147 1.00 24.42 ? 387 VAL A N 1 ATOM 3097 C CA . VAL A 1 387 ? 17.082 59.305 23.444 1.00 25.36 ? 387 VAL A CA 1 ATOM 3098 C C . VAL A 1 387 ? 16.834 59.467 21.952 1.00 26.10 ? 387 VAL A C 1 ATOM 3099 O O . VAL A 1 387 ? 16.230 58.602 21.315 1.00 27.11 ? 387 VAL A O 1 ATOM 3100 C CB . VAL A 1 387 ? 18.322 58.416 23.635 1.00 26.36 ? 387 VAL A CB 1 ATOM 3101 C CG1 . VAL A 1 387 ? 19.471 58.922 22.769 1.00 24.33 ? 387 VAL A CG1 1 ATOM 3102 C CG2 . VAL A 1 387 ? 18.722 58.410 25.100 1.00 25.55 ? 387 VAL A CG2 1 ATOM 3103 N N . ASP A 1 388 ? 17.291 60.587 21.403 1.00 25.62 ? 388 ASP A N 1 ATOM 3104 C CA . ASP A 1 388 ? 17.159 60.842 19.977 1.00 25.64 ? 388 ASP A CA 1 ATOM 3105 C C . ASP A 1 388 ? 18.436 60.314 19.333 1.00 25.95 ? 388 ASP A C 1 ATOM 3106 O O . ASP A 1 388 ? 19.513 60.885 19.516 1.00 25.77 ? 388 ASP A O 1 ATOM 3107 C CB . ASP A 1 388 ? 17.018 62.340 19.702 1.00 26.98 ? 388 ASP A CB 1 ATOM 3108 C CG . ASP A 1 388 ? 17.110 62.672 18.222 1.00 29.77 ? 388 ASP A CG 1 ATOM 3109 O OD1 . ASP A 1 388 ? 17.051 61.740 17.389 1.00 30.80 ? 388 ASP A OD1 1 ATOM 3110 O OD2 . ASP A 1 388 ? 17.236 63.867 17.889 1.00 30.12 ? 388 ASP A OD2 1 ATOM 3111 N N . PRO A 1 389 ? 18.332 59.214 18.568 1.00 26.68 ? 389 PRO A N 1 ATOM 3112 C CA . PRO A 1 389 ? 19.501 58.619 17.909 1.00 25.96 ? 389 PRO A CA 1 ATOM 3113 C C . PRO A 1 389 ? 20.305 59.566 17.027 1.00 25.69 ? 389 PRO A C 1 ATOM 3114 O O . PRO A 1 389 ? 21.524 59.442 16.951 1.00 26.11 ? 389 PRO A O 1 ATOM 3115 C CB . PRO A 1 389 ? 18.903 57.444 17.131 1.00 25.64 ? 389 PRO A CB 1 ATOM 3116 C CG . PRO A 1 389 ? 17.515 57.916 16.821 1.00 26.23 ? 389 PRO A CG 1 ATOM 3117 C CD . PRO A 1 389 ? 17.090 58.552 18.128 1.00 25.55 ? 389 PRO A CD 1 ATOM 3118 N N . GLN A 1 390 ? 19.651 60.514 16.360 1.00 25.85 ? 390 GLN A N 1 ATOM 3119 C CA . GLN A 1 390 ? 20.417 61.432 15.519 1.00 26.25 ? 390 GLN A CA 1 ATOM 3120 C C . GLN A 1 390 ? 21.269 62.356 16.380 1.00 26.03 ? 390 GLN A C 1 ATOM 3121 O O . GLN A 1 390 ? 22.427 62.627 16.058 1.00 26.14 ? 390 GLN A O 1 ATOM 3122 C CB . GLN A 1 390 ? 19.513 62.281 14.625 1.00 25.31 ? 390 GLN A CB 1 ATOM 3123 C CG . GLN A 1 390 ? 20.306 63.313 13.833 1.00 27.55 ? 390 GLN A CG 1 ATOM 3124 C CD . GLN A 1 390 ? 19.445 64.164 12.927 1.00 29.50 ? 390 GLN A CD 1 ATOM 3125 O OE1 . GLN A 1 390 ? 18.418 64.686 13.344 1.00 34.14 ? 390 GLN A OE1 1 ATOM 3126 N NE2 . GLN A 1 390 ? 19.870 64.320 11.684 1.00 29.94 ? 390 GLN A NE2 1 ATOM 3127 N N . ALA A 1 391 ? 20.691 62.848 17.472 1.00 25.46 ? 391 ALA A N 1 ATOM 3128 C CA . ALA A 1 391 ? 21.422 63.738 18.367 1.00 24.69 ? 391 ALA A CA 1 ATOM 3129 C C . ALA A 1 391 ? 22.632 62.982 18.915 1.00 23.85 ? 391 ALA A C 1 ATOM 3130 O O . ALA A 1 391 ? 23.748 63.511 18.968 1.00 21.63 ? 391 ALA A O 1 ATOM 3131 C CB . ALA A 1 391 ? 20.522 64.193 19.507 1.00 24.16 ? 391 ALA A CB 1 ATOM 3132 N N . LEU A 1 392 ? 22.403 61.731 19.301 1.00 21.49 ? 392 LEU A N 1 ATOM 3133 C CA . LEU A 1 392 ? 23.462 60.896 19.840 1.00 22.83 ? 392 LEU A CA 1 ATOM 3134 C C . LEU A 1 392 ? 24.590 60.691 18.826 1.00 24.00 ? 392 LEU A C 1 ATOM 3135 O O . LEU A 1 392 ? 25.766 60.785 19.177 1.00 25.58 ? 392 LEU A O 1 ATOM 3136 C CB . LEU A 1 392 ? 22.883 59.550 20.273 1.00 21.37 ? 392 LEU A CB 1 ATOM 3137 C CG . LEU A 1 392 ? 23.740 58.697 21.203 1.00 22.34 ? 392 LEU A CG 1 ATOM 3138 C CD1 . LEU A 1 392 ? 24.248 59.545 22.356 1.00 22.67 ? 392 LEU A CD1 1 ATOM 3139 C CD2 . LEU A 1 392 ? 22.914 57.532 21.720 1.00 20.39 ? 392 LEU A CD2 1 ATOM 3140 N N . CYS A 1 393 ? 24.240 60.429 17.570 1.00 23.65 ? 393 CYS A N 1 ATOM 3141 C CA . CYS A 1 393 ? 25.254 60.213 16.541 1.00 25.45 ? 393 CYS A CA 1 ATOM 3142 C C . CYS A 1 393 ? 26.049 61.476 16.245 1.00 26.24 ? 393 CYS A C 1 ATOM 3143 O O . CYS A 1 393 ? 27.243 61.411 15.949 1.00 26.33 ? 393 CYS A O 1 ATOM 3144 C CB . CYS A 1 393 ? 24.618 59.696 15.249 1.00 25.87 ? 393 CYS A CB 1 ATOM 3145 S SG . CYS A 1 393 ? 23.958 57.991 15.330 1.00 35.37 ? 393 CYS A SG 1 ATOM 3146 N N . ASN A 1 394 ? 25.384 62.625 16.311 1.00 25.65 ? 394 ASN A N 1 ATOM 3147 C CA . ASN A 1 394 ? 26.051 63.897 16.065 1.00 26.92 ? 394 ASN A CA 1 ATOM 3148 C C . ASN A 1 394 ? 26.950 64.255 17.243 1.00 27.59 ? 394 ASN A C 1 ATOM 3149 O O . ASN A 1 394 ? 27.993 64.880 17.070 1.00 27.55 ? 394 ASN A O 1 ATOM 3150 C CB . ASN A 1 394 ? 25.017 64.999 15.825 1.00 26.28 ? 394 ASN A CB 1 ATOM 3151 C CG . ASN A 1 394 ? 24.525 65.026 14.387 1.00 27.72 ? 394 ASN A CG 1 ATOM 3152 O OD1 . ASN A 1 394 ? 25.248 65.448 13.485 1.00 28.21 ? 394 ASN A OD1 1 ATOM 3153 N ND2 . ASN A 1 394 ? 23.300 64.559 14.165 1.00 26.13 ? 394 ASN A ND2 1 ATOM 3154 N N . GLU A 1 395 ? 26.549 63.847 18.442 1.00 28.21 ? 395 GLU A N 1 ATOM 3155 C CA . GLU A 1 395 ? 27.344 64.117 19.630 1.00 29.57 ? 395 GLU A CA 1 ATOM 3156 C C . GLU A 1 395 ? 28.547 63.172 19.706 1.00 29.40 ? 395 GLU A C 1 ATOM 3157 O O . GLU A 1 395 ? 29.647 63.584 20.073 1.00 27.83 ? 395 GLU A O 1 ATOM 3158 C CB . GLU A 1 395 ? 26.491 63.955 20.891 1.00 32.32 ? 395 GLU A CB 1 ATOM 3159 C CG . GLU A 1 395 ? 27.287 64.100 22.179 1.00 39.33 ? 395 GLU A CG 1 ATOM 3160 C CD . GLU A 1 395 ? 26.430 63.974 23.432 1.00 45.47 ? 395 GLU A CD 1 ATOM 3161 O OE1 . GLU A 1 395 ? 25.753 62.931 23.605 1.00 46.51 ? 395 GLU A OE1 1 ATOM 3162 O OE2 . GLU A 1 395 ? 26.442 64.924 24.250 1.00 48.24 ? 395 GLU A OE2 1 ATOM 3163 N N . ARG A 1 396 ? 28.334 61.906 19.350 1.00 28.39 ? 396 ARG A N 1 ATOM 3164 C CA . ARG A 1 396 ? 29.401 60.914 19.399 1.00 26.81 ? 396 ARG A CA 1 ATOM 3165 C C . ARG A 1 396 ? 29.734 60.318 18.037 1.00 25.98 ? 396 ARG A C 1 ATOM 3166 O O . ARG A 1 396 ? 29.195 59.278 17.657 1.00 24.69 ? 396 ARG A O 1 ATOM 3167 C CB . ARG A 1 396 ? 29.020 59.793 20.364 1.00 27.23 ? 396 ARG A CB 1 ATOM 3168 C CG . ARG A 1 396 ? 28.671 60.292 21.752 1.00 30.14 ? 396 ARG A CG 1 ATOM 3169 C CD . ARG A 1 396 ? 28.371 59.156 22.709 1.00 30.56 ? 396 ARG A CD 1 ATOM 3170 N NE . ARG A 1 396 ? 27.647 59.646 23.879 1.00 35.57 ? 396 ARG A NE 1 ATOM 3171 C CZ . ARG A 1 396 ? 27.200 58.882 24.875 1.00 36.37 ? 396 ARG A CZ 1 ATOM 3172 N NH1 . ARG A 1 396 ? 27.399 57.568 24.862 1.00 35.68 ? 396 ARG A NH1 1 ATOM 3173 N NH2 . ARG A 1 396 ? 26.544 59.438 25.886 1.00 34.63 ? 396 ARG A NH2 1 ATOM 3174 N N . GLY A 1 397 ? 30.631 60.979 17.310 1.00 24.13 ? 397 GLY A N 1 ATOM 3175 C CA . GLY A 1 397 ? 31.032 60.491 16.003 1.00 23.09 ? 397 GLY A CA 1 ATOM 3176 C C . GLY A 1 397 ? 32.038 59.358 16.112 1.00 24.50 ? 397 GLY A C 1 ATOM 3177 O O . GLY A 1 397 ? 32.246 58.797 17.192 1.00 23.30 ? 397 GLY A O 1 ATOM 3178 N N . ALA A 1 398 ? 32.669 59.024 14.992 1.00 24.46 ? 398 ALA A N 1 ATOM 3179 C CA . ALA A 1 398 ? 33.649 57.947 14.950 1.00 25.43 ? 398 ALA A CA 1 ATOM 3180 C C . ALA A 1 398 ? 34.853 58.203 15.857 1.00 26.39 ? 398 ALA A C 1 ATOM 3181 O O . ALA A 1 398 ? 35.578 57.272 16.210 1.00 26.55 ? 398 ALA A O 1 ATOM 3182 C CB . ALA A 1 398 ? 34.113 57.728 13.511 1.00 24.18 ? 398 ALA A CB 1 ATOM 3183 N N . SER A 1 399 ? 35.066 59.459 16.236 1.00 25.68 ? 399 SER A N 1 ATOM 3184 C CA . SER A 1 399 ? 36.191 59.808 17.099 1.00 25.42 ? 399 SER A CA 1 ATOM 3185 C C . SER A 1 399 ? 35.862 59.622 18.575 1.00 25.45 ? 399 SER A C 1 ATOM 3186 O O . SER A 1 399 ? 36.753 59.635 19.418 1.00 26.14 ? 399 SER A O 1 ATOM 3187 C CB . SER A 1 399 ? 36.616 61.252 16.856 1.00 25.45 ? 399 SER A CB 1 ATOM 3188 O OG . SER A 1 399 ? 35.554 62.139 17.157 1.00 28.62 ? 399 SER A OG 1 ATOM 3189 N N . SER A 1 400 ? 34.582 59.458 18.887 1.00 25.29 ? 400 SER A N 1 ATOM 3190 C CA . SER A 1 400 ? 34.154 59.259 20.268 1.00 26.37 ? 400 SER A CA 1 ATOM 3191 C C . SER A 1 400 ? 34.229 57.759 20.548 1.00 27.04 ? 400 SER A C 1 ATOM 3192 O O . SER A 1 400 ? 33.382 56.991 20.095 1.00 27.27 ? 400 SER A O 1 ATOM 3193 C CB . SER A 1 400 ? 32.720 59.772 20.451 1.00 27.61 ? 400 SER A CB 1 ATOM 3194 O OG . SER A 1 400 ? 32.257 59.560 21.773 1.00 30.62 ? 400 SER A OG 1 ATOM 3195 N N . ARG A 1 401 ? 35.248 57.344 21.291 1.00 26.68 ? 401 ARG A N 1 ATOM 3196 C CA . ARG A 1 401 ? 35.450 55.931 21.587 1.00 26.04 ? 401 ARG A CA 1 ATOM 3197 C C . ARG A 1 401 ? 34.593 55.372 22.718 1.00 26.05 ? 401 ARG A C 1 ATOM 3198 O O . ARG A 1 401 ? 34.583 55.909 23.822 1.00 27.81 ? 401 ARG A O 1 ATOM 3199 C CB . ARG A 1 401 ? 36.928 55.685 21.903 1.00 25.13 ? 401 ARG A CB 1 ATOM 3200 C CG . ARG A 1 401 ? 37.884 56.248 20.855 1.00 26.96 ? 401 ARG A CG 1 ATOM 3201 C CD . ARG A 1 401 ? 39.280 55.712 21.059 1.00 25.90 ? 401 ARG A CD 1 ATOM 3202 N NE . ARG A 1 401 ? 39.303 54.258 20.951 1.00 29.03 ? 401 ARG A NE 1 ATOM 3203 C CZ . ARG A 1 401 ? 40.287 53.486 21.403 1.00 30.24 ? 401 ARG A CZ 1 ATOM 3204 N NH1 . ARG A 1 401 ? 41.339 54.033 22.000 1.00 27.05 ? 401 ARG A NH1 1 ATOM 3205 N NH2 . ARG A 1 401 ? 40.216 52.165 21.267 1.00 29.02 ? 401 ARG A NH2 1 ATOM 3206 N N . GLY A 1 402 ? 33.883 54.282 22.436 1.00 24.14 ? 402 GLY A N 1 ATOM 3207 C CA . GLY A 1 402 ? 33.054 53.651 23.448 1.00 23.93 ? 402 GLY A CA 1 ATOM 3208 C C . GLY A 1 402 ? 33.578 52.259 23.762 1.00 25.42 ? 402 GLY A C 1 ATOM 3209 O O . GLY A 1 402 ? 34.731 51.944 23.453 1.00 26.08 ? 402 GLY A O 1 ATOM 3210 N N . ALA A 1 403 ? 32.753 51.427 24.392 1.00 24.85 ? 403 ALA A N 1 ATOM 3211 C CA . ALA A 1 403 ? 33.154 50.060 24.714 1.00 24.96 ? 403 ALA A CA 1 ATOM 3212 C C . ALA A 1 403 ? 32.875 49.253 23.454 1.00 25.01 ? 403 ALA A C 1 ATOM 3213 O O . ALA A 1 403 ? 33.797 48.793 22.780 1.00 24.65 ? 403 ALA A O 1 ATOM 3214 C CB . ALA A 1 403 ? 32.334 49.523 25.881 1.00 24.26 ? 403 ALA A CB 1 ATOM 3215 N N . LEU A 1 404 ? 31.593 49.085 23.146 1.00 24.08 ? 404 LEU A N 1 ATOM 3216 C CA . LEU A 1 404 ? 31.175 48.385 21.938 1.00 23.76 ? 404 LEU A CA 1 ATOM 3217 C C . LEU A 1 404 ? 30.770 49.477 20.951 1.00 23.94 ? 404 LEU A C 1 ATOM 3218 O O . LEU A 1 404 ? 29.647 49.982 20.980 1.00 23.87 ? 404 LEU A O 1 ATOM 3219 C CB . LEU A 1 404 ? 29.997 47.455 22.234 1.00 24.16 ? 404 LEU A CB 1 ATOM 3220 C CG . LEU A 1 404 ? 30.402 46.199 23.015 1.00 25.71 ? 404 LEU A CG 1 ATOM 3221 C CD1 . LEU A 1 404 ? 29.178 45.432 23.472 1.00 26.58 ? 404 LEU A CD1 1 ATOM 3222 C CD2 . LEU A 1 404 ? 31.276 45.329 22.127 1.00 25.92 ? 404 LEU A CD2 1 ATOM 3223 N N . GLY A 1 405 ? 31.712 49.850 20.095 1.00 23.60 ? 405 GLY A N 1 ATOM 3224 C CA . GLY A 1 405 ? 31.466 50.894 19.124 1.00 23.64 ? 405 GLY A CA 1 ATOM 3225 C C . GLY A 1 405 ? 32.398 52.061 19.395 1.00 24.37 ? 405 GLY A C 1 ATOM 3226 O O . GLY A 1 405 ? 32.889 52.220 20.515 1.00 24.69 ? 405 GLY A O 1 ATOM 3227 N N . PRO A 1 406 ? 32.655 52.905 18.391 1.00 24.27 ? 406 PRO A N 1 ATOM 3228 C CA . PRO A 1 406 ? 32.073 52.743 17.059 1.00 24.26 ? 406 PRO A CA 1 ATOM 3229 C C . PRO A 1 406 ? 32.833 51.758 16.178 1.00 24.34 ? 406 PRO A C 1 ATOM 3230 O O . PRO A 1 406 ? 34.063 51.767 16.138 1.00 23.55 ? 406 PRO A O 1 ATOM 3231 C CB . PRO A 1 406 ? 32.116 54.160 16.500 1.00 23.08 ? 406 PRO A CB 1 ATOM 3232 C CG . PRO A 1 406 ? 33.426 54.667 17.046 1.00 24.05 ? 406 PRO A CG 1 ATOM 3233 C CD . PRO A 1 406 ? 33.395 54.178 18.493 1.00 24.27 ? 406 PRO A CD 1 ATOM 3234 N N . PHE A 1 407 ? 32.095 50.897 15.485 1.00 24.83 ? 407 PHE A N 1 ATOM 3235 C CA . PHE A 1 407 ? 32.708 49.948 14.565 1.00 25.19 ? 407 PHE A CA 1 ATOM 3236 C C . PHE A 1 407 ? 31.843 49.853 13.316 1.00 24.93 ? 407 PHE A C 1 ATOM 3237 O O . PHE A 1 407 ? 30.617 49.795 13.397 1.00 25.02 ? 407 PHE A O 1 ATOM 3238 C CB . PHE A 1 407 ? 32.908 48.569 15.221 1.00 24.48 ? 407 PHE A CB 1 ATOM 3239 C CG . PHE A 1 407 ? 31.644 47.921 15.715 1.00 24.73 ? 407 PHE A CG 1 ATOM 3240 C CD1 . PHE A 1 407 ? 30.786 47.268 14.836 1.00 23.68 ? 407 PHE A CD1 1 ATOM 3241 C CD2 . PHE A 1 407 ? 31.321 47.948 17.070 1.00 25.16 ? 407 PHE A CD2 1 ATOM 3242 C CE1 . PHE A 1 407 ? 29.626 46.648 15.299 1.00 23.56 ? 407 PHE A CE1 1 ATOM 3243 C CE2 . PHE A 1 407 ? 30.162 47.332 17.544 1.00 24.02 ? 407 PHE A CE2 1 ATOM 3244 C CZ . PHE A 1 407 ? 29.313 46.680 16.655 1.00 23.71 ? 407 PHE A CZ 1 ATOM 3245 N N . GLY A 1 408 ? 32.493 49.876 12.159 1.00 25.23 ? 408 GLY A N 1 ATOM 3246 C CA . GLY A 1 408 ? 31.776 49.804 10.902 1.00 25.05 ? 408 GLY A CA 1 ATOM 3247 C C . GLY A 1 408 ? 32.674 50.105 9.718 1.00 26.19 ? 408 GLY A C 1 ATOM 3248 O O . GLY A 1 408 ? 33.811 49.628 9.652 1.00 26.01 ? 408 GLY A O 1 ATOM 3249 N N . LEU A 1 409 ? 32.172 50.912 8.788 1.00 25.80 ? 409 LEU A N 1 ATOM 3250 C CA . LEU A 1 409 ? 32.929 51.257 7.591 1.00 26.40 ? 409 LEU A CA 1 ATOM 3251 C C . LEU A 1 409 ? 33.304 52.716 7.439 1.00 25.17 ? 409 LEU A C 1 ATOM 3252 O O . LEU A 1 409 ? 32.626 53.610 7.942 1.00 24.28 ? 409 LEU A O 1 ATOM 3253 C CB . LEU A 1 409 ? 32.149 50.880 6.333 1.00 28.95 ? 409 LEU A CB 1 ATOM 3254 C CG . LEU A 1 409 ? 31.942 49.428 5.933 1.00 35.29 ? 409 LEU A CG 1 ATOM 3255 C CD1 . LEU A 1 409 ? 31.110 49.399 4.655 1.00 36.98 ? 409 LEU A CD1 1 ATOM 3256 C CD2 . LEU A 1 409 ? 33.289 48.746 5.717 1.00 36.57 ? 409 LEU A CD2 1 ATOM 3257 N N . LEU A 1 410 ? 34.398 52.932 6.719 1.00 24.75 ? 410 LEU A N 1 ATOM 3258 C CA . LEU A 1 410 ? 34.871 54.263 6.383 1.00 24.30 ? 410 LEU A CA 1 ATOM 3259 C C . LEU A 1 410 ? 34.737 54.245 4.863 1.00 24.20 ? 410 LEU A C 1 ATOM 3260 O O . LEU A 1 410 ? 35.487 53.541 4.179 1.00 24.44 ? 410 LEU A O 1 ATOM 3261 C CB . LEU A 1 410 ? 36.335 54.454 6.791 1.00 21.93 ? 410 LEU A CB 1 ATOM 3262 C CG . LEU A 1 410 ? 36.618 54.355 8.295 1.00 22.96 ? 410 LEU A CG 1 ATOM 3263 C CD1 . LEU A 1 410 ? 38.092 54.655 8.565 1.00 20.19 ? 410 LEU A CD1 1 ATOM 3264 C CD2 . LEU A 1 410 ? 35.730 55.330 9.052 1.00 21.85 ? 410 LEU A CD2 1 ATOM 3265 N N . ALA A 1 411 ? 33.754 54.978 4.344 1.00 22.79 ? 411 ALA A N 1 ATOM 3266 C CA . ALA A 1 411 ? 33.512 55.028 2.904 1.00 22.82 ? 411 ALA A CA 1 ATOM 3267 C C . ALA A 1 411 ? 33.880 56.392 2.327 1.00 22.93 ? 411 ALA A C 1 ATOM 3268 O O . ALA A 1 411 ? 33.951 57.378 3.058 1.00 24.83 ? 411 ALA A O 1 ATOM 3269 C CB . ALA A 1 411 ? 32.048 54.699 2.614 1.00 20.79 ? 411 ALA A CB 1 ATOM 3270 N N . MET A 1 412 ? 34.107 56.449 1.016 1.00 23.53 ? 412 MET A N 1 ATOM 3271 C CA . MET A 1 412 ? 34.493 57.697 0.359 1.00 23.56 ? 412 MET A CA 1 ATOM 3272 C C . MET A 1 412 ? 35.554 58.405 1.196 1.00 24.28 ? 412 MET A C 1 ATOM 3273 O O . MET A 1 412 ? 35.484 59.610 1.436 1.00 24.18 ? 412 MET A O 1 ATOM 3274 C CB . MET A 1 412 ? 33.282 58.614 0.176 1.00 23.55 ? 412 MET A CB 1 ATOM 3275 C CG . MET A 1 412 ? 32.248 58.089 -0.807 1.00 24.84 ? 412 MET A CG 1 ATOM 3276 S SD . MET A 1 412 ? 32.986 57.597 -2.380 1.00 27.53 ? 412 MET A SD 1 ATOM 3277 C CE . MET A 1 412 ? 33.554 59.189 -3.005 1.00 22.37 ? 412 MET A CE 1 ATOM 3278 N N . ALA A 1 413 ? 36.539 57.637 1.643 1.00 24.47 ? 413 ALA A N 1 ATOM 3279 C CA . ALA A 1 413 ? 37.614 58.172 2.460 1.00 24.29 ? 413 ALA A CA 1 ATOM 3280 C C . ALA A 1 413 ? 38.858 58.385 1.616 1.00 24.65 ? 413 ALA A C 1 ATOM 3281 O O . ALA A 1 413 ? 39.091 57.665 0.646 1.00 25.21 ? 413 ALA A O 1 ATOM 3282 C CB . ALA A 1 413 ? 37.918 57.215 3.604 1.00 20.90 ? 413 ALA A CB 1 ATOM 3283 N N . SER A 1 414 ? 39.653 59.384 1.980 1.00 25.89 ? 414 SER A N 1 ATOM 3284 C CA . SER A 1 414 ? 40.886 59.657 1.261 1.00 28.37 ? 414 SER A CA 1 ATOM 3285 C C . SER A 1 414 ? 41.977 58.765 1.843 1.00 30.92 ? 414 SER A C 1 ATOM 3286 O O . SER A 1 414 ? 41.823 58.204 2.931 1.00 29.76 ? 414 SER A O 1 ATOM 3287 C CB . SER A 1 414 ? 41.279 61.131 1.397 1.00 25.53 ? 414 SER A CB 1 ATOM 3288 O OG . SER A 1 414 ? 41.416 61.503 2.756 1.00 27.85 ? 414 SER A OG 1 ATOM 3289 N N . LYS A 1 415 ? 43.070 58.631 1.101 1.00 34.98 ? 415 LYS A N 1 ATOM 3290 C CA . LYS A 1 415 ? 44.203 57.812 1.511 1.00 37.44 ? 415 LYS A CA 1 ATOM 3291 C C . LYS A 1 415 ? 44.640 58.108 2.947 1.00 37.36 ? 415 LYS A C 1 ATOM 3292 O O . LYS A 1 415 ? 44.830 57.192 3.744 1.00 36.62 ? 415 LYS A O 1 ATOM 3293 C CB . LYS A 1 415 ? 45.372 58.056 0.554 1.00 41.92 ? 415 LYS A CB 1 ATOM 3294 C CG . LYS A 1 415 ? 46.624 57.243 0.846 1.00 47.59 ? 415 LYS A CG 1 ATOM 3295 C CD . LYS A 1 415 ? 46.413 55.757 0.580 1.00 52.81 ? 415 LYS A CD 1 ATOM 3296 C CE . LYS A 1 415 ? 47.724 54.987 0.721 1.00 54.75 ? 415 LYS A CE 1 ATOM 3297 N NZ . LYS A 1 415 ? 48.782 55.538 -0.179 1.00 55.41 ? 415 LYS A NZ 1 ATOM 3298 N N . ASP A 1 416 ? 44.787 59.389 3.271 1.00 37.48 ? 416 ASP A N 1 ATOM 3299 C CA . ASP A 1 416 ? 45.225 59.809 4.603 1.00 38.22 ? 416 ASP A CA 1 ATOM 3300 C C . ASP A 1 416 ? 44.109 59.927 5.643 1.00 36.71 ? 416 ASP A C 1 ATOM 3301 O O . ASP A 1 416 ? 44.365 60.294 6.793 1.00 36.39 ? 416 ASP A O 1 ATOM 3302 C CB . ASP A 1 416 ? 45.949 61.155 4.510 1.00 40.05 ? 416 ASP A CB 1 ATOM 3303 C CG . ASP A 1 416 ? 45.092 62.239 3.870 1.00 43.33 ? 416 ASP A CG 1 ATOM 3304 O OD1 . ASP A 1 416 ? 43.844 62.147 3.942 1.00 43.04 ? 416 ASP A OD1 1 ATOM 3305 O OD2 . ASP A 1 416 ? 45.668 63.194 3.306 1.00 45.88 ? 416 ASP A OD2 1 ATOM 3306 N N . LEU A 1 417 ? 42.880 59.630 5.236 1.00 34.29 ? 417 LEU A N 1 ATOM 3307 C CA . LEU A 1 417 ? 41.721 59.711 6.119 1.00 32.13 ? 417 LEU A CA 1 ATOM 3308 C C . LEU A 1 417 ? 41.386 61.130 6.590 1.00 32.13 ? 417 LEU A C 1 ATOM 3309 O O . LEU A 1 417 ? 40.686 61.304 7.586 1.00 30.58 ? 417 LEU A O 1 ATOM 3310 C CB . LEU A 1 417 ? 41.901 58.799 7.337 1.00 29.85 ? 417 LEU A CB 1 ATOM 3311 C CG . LEU A 1 417 ? 41.856 57.284 7.104 1.00 30.33 ? 417 LEU A CG 1 ATOM 3312 C CD1 . LEU A 1 417 ? 41.945 56.573 8.446 1.00 27.19 ? 417 LEU A CD1 1 ATOM 3313 C CD2 . LEU A 1 417 ? 40.564 56.891 6.393 1.00 28.42 ? 417 LEU A CD2 1 ATOM 3314 N N . LYS A 1 418 ? 41.878 62.145 5.883 1.00 32.93 ? 418 LYS A N 1 ATOM 3315 C CA . LYS A 1 418 ? 41.563 63.522 6.257 1.00 33.96 ? 418 LYS A CA 1 ATOM 3316 C C . LYS A 1 418 ? 40.083 63.761 5.962 1.00 32.35 ? 418 LYS A C 1 ATOM 3317 O O . LYS A 1 418 ? 39.460 64.658 6.529 1.00 33.70 ? 418 LYS A O 1 ATOM 3318 C CB . LYS A 1 418 ? 42.442 64.515 5.487 1.00 37.80 ? 418 LYS A CB 1 ATOM 3319 C CG . LYS A 1 418 ? 43.877 64.587 6.013 1.00 44.12 ? 418 LYS A CG 1 ATOM 3320 C CD . LYS A 1 418 ? 44.729 65.570 5.221 1.00 49.07 ? 418 LYS A CD 1 ATOM 3321 C CE . LYS A 1 418 ? 46.161 65.615 5.747 1.00 52.01 ? 418 LYS A CE 1 ATOM 3322 N NZ . LYS A 1 418 ? 47.039 66.494 4.912 1.00 54.09 ? 418 LYS A NZ 1 ATOM 3323 N N . GLU A 1 419 ? 39.534 62.947 5.063 1.00 28.46 ? 419 GLU A N 1 ATOM 3324 C CA . GLU A 1 419 ? 38.118 63.000 4.709 1.00 27.25 ? 419 GLU A CA 1 ATOM 3325 C C . GLU A 1 419 ? 37.597 61.562 4.757 1.00 26.35 ? 419 GLU A C 1 ATOM 3326 O O . GLU A 1 419 ? 38.242 60.643 4.250 1.00 25.45 ? 419 GLU A O 1 ATOM 3327 C CB . GLU A 1 419 ? 37.915 63.605 3.312 1.00 25.81 ? 419 GLU A CB 1 ATOM 3328 C CG . GLU A 1 419 ? 38.182 65.106 3.252 1.00 27.10 ? 419 GLU A CG 1 ATOM 3329 C CD . GLU A 1 419 ? 37.967 65.700 1.870 1.00 28.87 ? 419 GLU A CD 1 ATOM 3330 O OE1 . GLU A 1 419 ? 38.638 65.258 0.911 1.00 30.16 ? 419 GLU A OE1 1 ATOM 3331 O OE2 . GLU A 1 419 ? 37.127 66.616 1.742 1.00 31.07 ? 419 GLU A OE2 1 ATOM 3332 N N . GLN A 1 420 ? 36.442 61.367 5.384 1.00 24.92 ? 420 GLN A N 1 ATOM 3333 C CA . GLN A 1 420 ? 35.863 60.035 5.509 1.00 24.66 ? 420 GLN A CA 1 ATOM 3334 C C . GLN A 1 420 ? 34.401 60.111 5.910 1.00 24.98 ? 420 GLN A C 1 ATOM 3335 O O . GLN A 1 420 ? 33.968 61.079 6.536 1.00 24.47 ? 420 GLN A O 1 ATOM 3336 C CB . GLN A 1 420 ? 36.601 59.232 6.589 1.00 24.45 ? 420 GLN A CB 1 ATOM 3337 C CG . GLN A 1 420 ? 36.519 59.886 7.967 1.00 24.78 ? 420 GLN A CG 1 ATOM 3338 C CD . GLN A 1 420 ? 37.106 59.040 9.088 1.00 26.73 ? 420 GLN A CD 1 ATOM 3339 O OE1 . GLN A 1 420 ? 38.222 58.527 8.979 1.00 26.70 ? 420 GLN A OE1 1 ATOM 3340 N NE2 . GLN A 1 420 ? 36.358 58.906 10.183 1.00 22.74 ? 420 GLN A NE2 1 ATOM 3341 N N . SER A 1 421 ? 33.650 59.077 5.548 1.00 22.97 ? 421 SER A N 1 ATOM 3342 C CA . SER A 1 421 ? 32.247 58.981 5.917 1.00 22.71 ? 421 SER A CA 1 ATOM 3343 C C . SER A 1 421 ? 32.177 57.686 6.705 1.00 23.46 ? 421 SER A C 1 ATOM 3344 O O . SER A 1 421 ? 32.409 56.607 6.161 1.00 24.46 ? 421 SER A O 1 ATOM 3345 C CB . SER A 1 421 ? 31.355 58.904 4.680 1.00 22.10 ? 421 SER A CB 1 ATOM 3346 O OG . SER A 1 421 ? 31.412 60.116 3.948 1.00 22.80 ? 421 SER A OG 1 ATOM 3347 N N . ALA A 1 422 ? 31.882 57.800 7.994 1.00 22.46 ? 422 ALA A N 1 ATOM 3348 C CA . ALA A 1 422 ? 31.818 56.638 8.867 1.00 21.05 ? 422 ALA A CA 1 ATOM 3349 C C . ALA A 1 422 ? 30.401 56.135 9.135 1.00 21.91 ? 422 ALA A C 1 ATOM 3350 O O . ALA A 1 422 ? 29.568 56.854 9.692 1.00 21.59 ? 422 ALA A O 1 ATOM 3351 C CB . ALA A 1 422 ? 32.513 56.957 10.188 1.00 19.07 ? 422 ALA A CB 1 ATOM 3352 N N . ILE A 1 423 ? 30.139 54.895 8.728 1.00 22.08 ? 423 ILE A N 1 ATOM 3353 C CA . ILE A 1 423 ? 28.847 54.251 8.948 1.00 22.15 ? 423 ILE A CA 1 ATOM 3354 C C . ILE A 1 423 ? 29.169 53.203 10.014 1.00 23.10 ? 423 ILE A C 1 ATOM 3355 O O . ILE A 1 423 ? 29.927 52.265 9.759 1.00 23.39 ? 423 ILE A O 1 ATOM 3356 C CB . ILE A 1 423 ? 28.339 53.550 7.671 1.00 23.29 ? 423 ILE A CB 1 ATOM 3357 C CG1 . ILE A 1 423 ? 28.558 54.455 6.451 1.00 22.64 ? 423 ILE A CG1 1 ATOM 3358 C CG2 . ILE A 1 423 ? 26.859 53.196 7.826 1.00 20.98 ? 423 ILE A CG2 1 ATOM 3359 C CD1 . ILE A 1 423 ? 27.886 55.811 6.552 1.00 22.16 ? 423 ILE A CD1 1 ATOM 3360 N N . PHE A 1 424 ? 28.603 53.356 11.206 1.00 22.36 ? 424 PHE A N 1 ATOM 3361 C CA . PHE A 1 424 ? 28.929 52.433 12.281 1.00 21.77 ? 424 PHE A CA 1 ATOM 3362 C C . PHE A 1 424 ? 27.815 52.130 13.271 1.00 22.93 ? 424 PHE A C 1 ATOM 3363 O O . PHE A 1 424 ? 26.716 52.685 13.200 1.00 23.37 ? 424 PHE A O 1 ATOM 3364 C CB . PHE A 1 424 ? 30.141 52.977 13.041 1.00 20.92 ? 424 PHE A CB 1 ATOM 3365 C CG . PHE A 1 424 ? 29.886 54.297 13.735 1.00 20.68 ? 424 PHE A CG 1 ATOM 3366 C CD1 . PHE A 1 424 ? 29.186 54.347 14.941 1.00 20.50 ? 424 PHE A CD1 1 ATOM 3367 C CD2 . PHE A 1 424 ? 30.365 55.488 13.192 1.00 19.79 ? 424 PHE A CD2 1 ATOM 3368 C CE1 . PHE A 1 424 ? 28.971 55.566 15.601 1.00 19.43 ? 424 PHE A CE1 1 ATOM 3369 C CE2 . PHE A 1 424 ? 30.155 56.710 13.842 1.00 20.02 ? 424 PHE A CE2 1 ATOM 3370 C CZ . PHE A 1 424 ? 29.457 56.747 15.051 1.00 17.60 ? 424 PHE A CZ 1 ATOM 3371 N N . PHE A 1 425 ? 28.130 51.244 14.209 1.00 22.93 ? 425 PHE A N 1 ATOM 3372 C CA . PHE A 1 425 ? 27.195 50.832 15.243 1.00 23.25 ? 425 PHE A CA 1 ATOM 3373 C C . PHE A 1 425 ? 27.799 51.046 16.624 1.00 23.78 ? 425 PHE A C 1 ATOM 3374 O O . PHE A 1 425 ? 29.013 51.194 16.770 1.00 23.58 ? 425 PHE A O 1 ATOM 3375 C CB . PHE A 1 425 ? 26.871 49.346 15.106 1.00 21.53 ? 425 PHE A CB 1 ATOM 3376 C CG . PHE A 1 425 ? 26.261 48.970 13.793 1.00 22.01 ? 425 PHE A CG 1 ATOM 3377 C CD1 . PHE A 1 425 ? 24.924 49.242 13.531 1.00 20.07 ? 425 PHE A CD1 1 ATOM 3378 C CD2 . PHE A 1 425 ? 27.021 48.322 12.821 1.00 22.05 ? 425 PHE A CD2 1 ATOM 3379 C CE1 . PHE A 1 425 ? 24.348 48.871 12.321 1.00 19.94 ? 425 PHE A CE1 1 ATOM 3380 C CE2 . PHE A 1 425 ? 26.455 47.947 11.604 1.00 23.01 ? 425 PHE A CE2 1 ATOM 3381 C CZ . PHE A 1 425 ? 25.115 48.221 11.353 1.00 22.26 ? 425 PHE A CZ 1 ATOM 3382 N N . ARG A 1 426 ? 26.926 51.065 17.628 1.00 24.00 ? 426 ARG A N 1 ATOM 3383 C CA . ARG A 1 426 ? 27.318 51.184 19.029 1.00 23.22 ? 426 ARG A CA 1 ATOM 3384 C C . ARG A 1 426 ? 26.313 50.273 19.717 1.00 22.70 ? 426 ARG A C 1 ATOM 3385 O O . ARG A 1 426 ? 25.190 50.118 19.236 1.00 23.97 ? 426 ARG A O 1 ATOM 3386 C CB . ARG A 1 426 ? 27.161 52.617 19.565 1.00 20.67 ? 426 ARG A CB 1 ATOM 3387 C CG . ARG A 1 426 ? 27.826 53.693 18.726 1.00 25.07 ? 426 ARG A CG 1 ATOM 3388 C CD . ARG A 1 426 ? 27.907 55.026 19.468 1.00 22.63 ? 426 ARG A CD 1 ATOM 3389 N NE . ARG A 1 426 ? 29.149 55.084 20.218 1.00 27.58 ? 426 ARG A NE 1 ATOM 3390 C CZ . ARG A 1 426 ? 30.188 55.849 19.909 1.00 26.08 ? 426 ARG A CZ 1 ATOM 3391 N NH1 . ARG A 1 426 ? 30.156 56.662 18.864 1.00 23.90 ? 426 ARG A NH1 1 ATOM 3392 N NH2 . ARG A 1 426 ? 31.289 55.757 20.632 1.00 29.61 ? 426 ARG A NH2 1 ATOM 3393 N N . VAL A 1 427 ? 26.712 49.638 20.810 1.00 23.12 ? 427 VAL A N 1 ATOM 3394 C CA . VAL A 1 427 ? 25.795 48.772 21.535 1.00 22.59 ? 427 VAL A CA 1 ATOM 3395 C C . VAL A 1 427 ? 25.730 49.259 22.974 1.00 24.04 ? 427 VAL A C 1 ATOM 3396 O O . VAL A 1 427 ? 26.757 49.481 23.614 1.00 24.08 ? 427 VAL A O 1 ATOM 3397 C CB . VAL A 1 427 ? 26.252 47.293 21.506 1.00 23.85 ? 427 VAL A CB 1 ATOM 3398 C CG1 . VAL A 1 427 ? 25.241 46.417 22.251 1.00 21.45 ? 427 VAL A CG1 1 ATOM 3399 C CG2 . VAL A 1 427 ? 26.388 46.817 20.058 1.00 20.66 ? 427 VAL A CG2 1 ATOM 3400 N N . PHE A 1 428 ? 24.512 49.449 23.465 1.00 25.02 ? 428 PHE A N 1 ATOM 3401 C CA . PHE A 1 428 ? 24.285 49.919 24.824 1.00 24.51 ? 428 PHE A CA 1 ATOM 3402 C C . PHE A 1 428 ? 23.393 48.920 25.541 1.00 25.82 ? 428 PHE A C 1 ATOM 3403 O O . PHE A 1 428 ? 22.876 47.979 24.936 1.00 26.16 ? 428 PHE A O 1 ATOM 3404 C CB . PHE A 1 428 ? 23.565 51.274 24.810 1.00 22.91 ? 428 PHE A CB 1 ATOM 3405 C CG . PHE A 1 428 ? 24.328 52.371 24.124 1.00 21.78 ? 428 PHE A CG 1 ATOM 3406 C CD1 . PHE A 1 428 ? 25.444 52.940 24.721 1.00 20.33 ? 428 PHE A CD1 1 ATOM 3407 C CD2 . PHE A 1 428 ? 23.918 52.846 22.880 1.00 20.84 ? 428 PHE A CD2 1 ATOM 3408 C CE1 . PHE A 1 428 ? 26.145 53.970 24.094 1.00 18.72 ? 428 PHE A CE1 1 ATOM 3409 C CE2 . PHE A 1 428 ? 24.610 53.874 22.243 1.00 19.90 ? 428 PHE A CE2 1 ATOM 3410 C CZ . PHE A 1 428 ? 25.726 54.437 22.853 1.00 19.14 ? 428 PHE A CZ 1 ATOM 3411 N N . GLN A 1 429 ? 23.212 49.139 26.837 1.00 26.15 ? 429 GLN A N 1 ATOM 3412 C CA . GLN A 1 429 ? 22.343 48.300 27.646 1.00 25.61 ? 429 GLN A CA 1 ATOM 3413 C C . GLN A 1 429 ? 21.713 49.198 28.706 1.00 27.10 ? 429 GLN A C 1 ATOM 3414 O O . GLN A 1 429 ? 22.357 50.128 29.201 1.00 24.96 ? 429 GLN A O 1 ATOM 3415 C CB . GLN A 1 429 ? 23.133 47.165 28.312 1.00 25.40 ? 429 GLN A CB 1 ATOM 3416 C CG . GLN A 1 429 ? 24.095 47.586 29.418 1.00 26.05 ? 429 GLN A CG 1 ATOM 3417 C CD . GLN A 1 429 ? 24.823 46.396 30.039 1.00 27.67 ? 429 GLN A CD 1 ATOM 3418 O OE1 . GLN A 1 429 ? 26.049 46.284 29.948 1.00 28.49 ? 429 GLN A OE1 1 ATOM 3419 N NE2 . GLN A 1 429 ? 24.067 45.501 30.669 1.00 24.60 ? 429 GLN A NE2 1 ATOM 3420 N N . ASN A 1 430 ? 20.448 48.952 29.030 1.00 28.05 ? 430 ASN A N 1 ATOM 3421 C CA . ASN A 1 430 ? 19.793 49.747 30.056 1.00 30.37 ? 430 ASN A CA 1 ATOM 3422 C C . ASN A 1 430 ? 20.175 49.150 31.406 1.00 33.11 ? 430 ASN A C 1 ATOM 3423 O O . ASN A 1 430 ? 20.993 48.229 31.472 1.00 33.09 ? 430 ASN A O 1 ATOM 3424 C CB . ASN A 1 430 ? 18.270 49.749 29.877 1.00 28.88 ? 430 ASN A CB 1 ATOM 3425 C CG . ASN A 1 430 ? 17.662 48.371 29.982 1.00 29.07 ? 430 ASN A CG 1 ATOM 3426 O OD1 . ASN A 1 430 ? 18.326 47.409 30.368 1.00 30.72 ? 430 ASN A OD1 1 ATOM 3427 N ND2 . ASN A 1 430 ? 16.384 48.268 29.644 1.00 26.78 ? 430 ASN A ND2 1 ATOM 3428 N N . GLN A 1 431 ? 19.587 49.663 32.479 1.00 36.11 ? 431 GLN A N 1 ATOM 3429 C CA . GLN A 1 431 ? 19.915 49.173 33.810 1.00 39.71 ? 431 GLN A CA 1 ATOM 3430 C C . GLN A 1 431 ? 19.558 47.700 34.017 1.00 39.80 ? 431 GLN A C 1 ATOM 3431 O O . GLN A 1 431 ? 20.244 46.993 34.755 1.00 39.57 ? 431 GLN A O 1 ATOM 3432 C CB . GLN A 1 431 ? 19.223 50.035 34.873 1.00 42.52 ? 431 GLN A CB 1 ATOM 3433 C CG . GLN A 1 431 ? 19.906 49.996 36.234 1.00 47.30 ? 431 GLN A CG 1 ATOM 3434 C CD . GLN A 1 431 ? 21.396 50.326 36.146 1.00 50.56 ? 431 GLN A CD 1 ATOM 3435 O OE1 . GLN A 1 431 ? 21.791 51.343 35.564 1.00 50.53 ? 431 GLN A OE1 1 ATOM 3436 N NE2 . GLN A 1 431 ? 22.227 49.466 36.728 1.00 50.81 ? 431 GLN A NE2 1 ATOM 3437 N N . LEU A 1 432 ? 18.500 47.234 33.359 1.00 39.79 ? 432 LEU A N 1 ATOM 3438 C CA . LEU A 1 432 ? 18.066 45.845 33.503 1.00 39.72 ? 432 LEU A CA 1 ATOM 3439 C C . LEU A 1 432 ? 18.787 44.857 32.590 1.00 39.77 ? 432 LEU A C 1 ATOM 3440 O O . LEU A 1 432 ? 18.366 43.708 32.454 1.00 39.23 ? 432 LEU A O 1 ATOM 3441 C CB . LEU A 1 432 ? 16.554 45.729 33.278 1.00 41.55 ? 432 LEU A CB 1 ATOM 3442 C CG . LEU A 1 432 ? 15.628 46.512 34.219 1.00 44.56 ? 432 LEU A CG 1 ATOM 3443 C CD1 . LEU A 1 432 ? 16.045 46.264 35.668 1.00 44.95 ? 432 LEU A CD1 1 ATOM 3444 C CD2 . LEU A 1 432 ? 15.694 48.002 33.902 1.00 46.10 ? 432 LEU A CD2 1 ATOM 3445 N N . GLY A 1 433 ? 19.866 45.300 31.957 1.00 39.02 ? 433 GLY A N 1 ATOM 3446 C CA . GLY A 1 433 ? 20.613 44.408 31.090 1.00 38.91 ? 433 GLY A CA 1 ATOM 3447 C C . GLY A 1 433 ? 20.078 44.202 29.683 1.00 39.54 ? 433 GLY A C 1 ATOM 3448 O O . GLY A 1 433 ? 20.566 43.329 28.966 1.00 39.69 ? 433 GLY A O 1 ATOM 3449 N N . ARG A 1 434 ? 19.075 44.976 29.279 1.00 39.41 ? 434 ARG A N 1 ATOM 3450 C CA . ARG A 1 434 ? 18.540 44.850 27.926 1.00 40.63 ? 434 ARG A CA 1 ATOM 3451 C C . ARG A 1 434 ? 19.403 45.682 26.985 1.00 37.67 ? 434 ARG A C 1 ATOM 3452 O O . ARG A 1 434 ? 19.763 46.814 27.300 1.00 38.16 ? 434 ARG A O 1 ATOM 3453 C CB . ARG A 1 434 ? 17.087 45.325 27.868 1.00 45.44 ? 434 ARG A CB 1 ATOM 3454 C CG . ARG A 1 434 ? 16.081 44.194 27.694 1.00 54.66 ? 434 ARG A CG 1 ATOM 3455 C CD . ARG A 1 434 ? 16.284 43.100 28.748 1.00 62.21 ? 434 ARG A CD 1 ATOM 3456 N NE . ARG A 1 434 ? 15.435 41.924 28.535 1.00 68.41 ? 434 ARG A NE 1 ATOM 3457 C CZ . ARG A 1 434 ? 15.400 41.206 27.413 1.00 71.64 ? 434 ARG A CZ 1 ATOM 3458 N NH1 . ARG A 1 434 ? 16.162 41.537 26.376 1.00 72.81 ? 434 ARG A NH1 1 ATOM 3459 N NH2 . ARG A 1 434 ? 14.609 40.141 27.332 1.00 73.22 ? 434 ARG A NH2 1 ATOM 3460 N N . TYR A 1 435 ? 19.735 45.115 25.832 1.00 33.80 ? 435 TYR A N 1 ATOM 3461 C CA . TYR A 1 435 ? 20.579 45.799 24.862 1.00 32.01 ? 435 TYR A CA 1 ATOM 3462 C C . TYR A 1 435 ? 19.811 46.551 23.792 1.00 31.17 ? 435 TYR A C 1 ATOM 3463 O O . TYR A 1 435 ? 18.677 46.210 23.465 1.00 31.93 ? 435 TYR A O 1 ATOM 3464 C CB . TYR A 1 435 ? 21.492 44.791 24.170 1.00 30.63 ? 435 TYR A CB 1 ATOM 3465 C CG . TYR A 1 435 ? 22.373 44.028 25.117 1.00 31.04 ? 435 TYR A CG 1 ATOM 3466 C CD1 . TYR A 1 435 ? 23.458 44.645 25.738 1.00 31.19 ? 435 TYR A CD1 1 ATOM 3467 C CD2 . TYR A 1 435 ? 22.112 42.695 25.413 1.00 30.45 ? 435 TYR A CD2 1 ATOM 3468 C CE1 . TYR A 1 435 ? 24.263 43.951 26.631 1.00 32.27 ? 435 TYR A CE1 1 ATOM 3469 C CE2 . TYR A 1 435 ? 22.909 41.989 26.305 1.00 32.14 ? 435 TYR A CE2 1 ATOM 3470 C CZ . TYR A 1 435 ? 23.983 42.622 26.908 1.00 31.74 ? 435 TYR A CZ 1 ATOM 3471 O OH . TYR A 1 435 ? 24.786 41.922 27.776 1.00 32.18 ? 435 TYR A OH 1 ATOM 3472 N N . SER A 1 436 ? 20.448 47.584 23.255 1.00 28.94 ? 436 SER A N 1 ATOM 3473 C CA . SER A 1 436 ? 19.876 48.372 22.174 1.00 27.33 ? 436 SER A CA 1 ATOM 3474 C C . SER A 1 436 ? 21.039 48.608 21.212 1.00 25.48 ? 436 SER A C 1 ATOM 3475 O O . SER A 1 436 ? 22.203 48.616 21.627 1.00 25.34 ? 436 SER A O 1 ATOM 3476 C CB . SER A 1 436 ? 19.310 49.705 22.685 1.00 25.83 ? 436 SER A CB 1 ATOM 3477 O OG . SER A 1 436 ? 20.342 50.610 23.026 1.00 29.76 ? 436 SER A OG 1 ATOM 3478 N N . VAL A 1 437 ? 20.727 48.776 19.932 1.00 23.47 ? 437 VAL A N 1 ATOM 3479 C CA . VAL A 1 437 ? 21.751 48.985 18.918 1.00 20.56 ? 437 VAL A CA 1 ATOM 3480 C C . VAL A 1 437 ? 21.548 50.296 18.178 1.00 20.82 ? 437 VAL A C 1 ATOM 3481 O O . VAL A 1 437 ? 20.452 50.589 17.697 1.00 21.29 ? 437 VAL A O 1 ATOM 3482 C CB . VAL A 1 437 ? 21.751 47.814 17.906 1.00 21.10 ? 437 VAL A CB 1 ATOM 3483 C CG1 . VAL A 1 437 ? 22.792 48.047 16.807 1.00 18.14 ? 437 VAL A CG1 1 ATOM 3484 C CG2 . VAL A 1 437 ? 22.031 46.505 18.648 1.00 20.18 ? 437 VAL A CG2 1 ATOM 3485 N N . LEU A 1 438 ? 22.613 51.086 18.092 1.00 20.61 ? 438 LEU A N 1 ATOM 3486 C CA . LEU A 1 438 ? 22.558 52.371 17.410 1.00 20.70 ? 438 LEU A CA 1 ATOM 3487 C C . LEU A 1 438 ? 23.332 52.303 16.101 1.00 21.91 ? 438 LEU A C 1 ATOM 3488 O O . LEU A 1 438 ? 24.436 51.756 16.053 1.00 22.89 ? 438 LEU A O 1 ATOM 3489 C CB . LEU A 1 438 ? 23.155 53.466 18.300 1.00 20.41 ? 438 LEU A CB 1 ATOM 3490 C CG . LEU A 1 438 ? 23.309 54.858 17.667 1.00 23.21 ? 438 LEU A CG 1 ATOM 3491 C CD1 . LEU A 1 438 ? 21.945 55.522 17.530 1.00 20.56 ? 438 LEU A CD1 1 ATOM 3492 C CD2 . LEU A 1 438 ? 24.236 55.715 18.523 1.00 22.32 ? 438 LEU A CD2 1 ATOM 3493 N N . MET A 1 439 ? 22.744 52.850 15.040 1.00 22.31 ? 439 MET A N 1 ATOM 3494 C CA . MET A 1 439 ? 23.389 52.875 13.730 1.00 23.03 ? 439 MET A CA 1 ATOM 3495 C C . MET A 1 439 ? 23.606 54.339 13.362 1.00 23.70 ? 439 MET A C 1 ATOM 3496 O O . MET A 1 439 ? 22.673 55.139 13.399 1.00 24.63 ? 439 MET A O 1 ATOM 3497 C CB . MET A 1 439 ? 22.508 52.204 12.675 1.00 22.72 ? 439 MET A CB 1 ATOM 3498 C CG . MET A 1 439 ? 23.136 52.181 11.289 1.00 23.81 ? 439 MET A CG 1 ATOM 3499 S SD . MET A 1 439 ? 22.066 51.483 10.025 1.00 27.02 ? 439 MET A SD 1 ATOM 3500 C CE . MET A 1 439 ? 22.753 52.198 8.547 1.00 23.59 ? 439 MET A CE 1 ATOM 3501 N N . CYS A 1 440 ? 24.835 54.687 13.005 1.00 23.57 ? 440 CYS A N 1 ATOM 3502 C CA . CYS A 1 440 ? 25.157 56.065 12.668 1.00 23.45 ? 440 CYS A CA 1 ATOM 3503 C C . CYS A 1 440 ? 25.814 56.267 11.316 1.00 24.65 ? 440 CYS A C 1 ATOM 3504 O O . CYS A 1 440 ? 26.544 55.409 10.823 1.00 25.77 ? 440 CYS A O 1 ATOM 3505 C CB . CYS A 1 440 ? 26.130 56.650 13.688 1.00 24.67 ? 440 CYS A CB 1 ATOM 3506 S SG . CYS A 1 440 ? 25.607 56.801 15.419 1.00 27.50 ? 440 CYS A SG 1 ATOM 3507 N N . SER A 1 441 ? 25.561 57.434 10.740 1.00 25.11 ? 441 SER A N 1 ATOM 3508 C CA . SER A 1 441 ? 26.188 57.853 9.498 1.00 26.28 ? 441 SER A CA 1 ATOM 3509 C C . SER A 1 441 ? 26.845 59.170 9.909 1.00 26.90 ? 441 SER A C 1 ATOM 3510 O O . SER A 1 441 ? 26.217 60.231 9.884 1.00 26.60 ? 441 SER A O 1 ATOM 3511 C CB . SER A 1 441 ? 25.159 58.094 8.395 1.00 27.64 ? 441 SER A CB 1 ATOM 3512 O OG . SER A 1 441 ? 24.657 56.866 7.901 1.00 31.35 ? 441 SER A OG 1 ATOM 3513 N N . ASP A 1 442 ? 28.099 59.076 10.342 1.00 25.97 ? 442 ASP A N 1 ATOM 3514 C CA . ASP A 1 442 ? 28.868 60.233 10.780 1.00 24.29 ? 442 ASP A CA 1 ATOM 3515 C C . ASP A 1 442 ? 29.461 60.901 9.551 1.00 23.88 ? 442 ASP A C 1 ATOM 3516 O O . ASP A 1 442 ? 30.402 60.391 8.948 1.00 23.25 ? 442 ASP A O 1 ATOM 3517 C CB . ASP A 1 442 ? 29.977 59.779 11.741 1.00 24.70 ? 442 ASP A CB 1 ATOM 3518 C CG . ASP A 1 442 ? 30.946 60.895 12.109 1.00 25.84 ? 442 ASP A CG 1 ATOM 3519 O OD1 . ASP A 1 442 ? 30.750 62.053 11.677 1.00 26.17 ? 442 ASP A OD1 1 ATOM 3520 O OD2 . ASP A 1 442 ? 31.914 60.603 12.844 1.00 25.61 ? 442 ASP A OD2 1 ATOM 3521 N N . LEU A 1 443 ? 28.896 62.044 9.184 1.00 23.87 ? 443 LEU A N 1 ATOM 3522 C CA . LEU A 1 443 ? 29.347 62.798 8.021 1.00 23.58 ? 443 LEU A CA 1 ATOM 3523 C C . LEU A 1 443 ? 30.146 64.041 8.422 1.00 24.66 ? 443 LEU A C 1 ATOM 3524 O O . LEU A 1 443 ? 30.523 64.845 7.567 1.00 24.85 ? 443 LEU A O 1 ATOM 3525 C CB . LEU A 1 443 ? 28.130 63.211 7.186 1.00 21.77 ? 443 LEU A CB 1 ATOM 3526 C CG . LEU A 1 443 ? 27.527 62.214 6.184 1.00 22.24 ? 443 LEU A CG 1 ATOM 3527 C CD1 . LEU A 1 443 ? 27.826 60.788 6.586 1.00 19.53 ? 443 LEU A CD1 1 ATOM 3528 C CD2 . LEU A 1 443 ? 26.030 62.461 6.068 1.00 17.50 ? 443 LEU A CD2 1 ATOM 3529 N N . SER A 1 444 ? 30.408 64.184 9.721 1.00 24.21 ? 444 SER A N 1 ATOM 3530 C CA . SER A 1 444 ? 31.136 65.340 10.247 1.00 26.09 ? 444 SER A CA 1 ATOM 3531 C C . SER A 1 444 ? 32.466 65.611 9.554 1.00 25.73 ? 444 SER A C 1 ATOM 3532 O O . SER A 1 444 ? 32.875 66.764 9.425 1.00 27.04 ? 444 SER A O 1 ATOM 3533 C CB . SER A 1 444 ? 31.381 65.183 11.750 1.00 24.92 ? 444 SER A CB 1 ATOM 3534 O OG . SER A 1 444 ? 32.299 64.138 12.013 1.00 29.93 ? 444 SER A OG 1 ATOM 3535 N N . ARG A 1 445 ? 33.138 64.558 9.108 1.00 25.73 ? 445 ARG A N 1 ATOM 3536 C CA . ARG A 1 445 ? 34.418 64.719 8.428 1.00 26.19 ? 445 ARG A CA 1 ATOM 3537 C C . ARG A 1 445 ? 34.368 64.211 6.993 1.00 26.14 ? 445 ARG A C 1 ATOM 3538 O O . ARG A 1 445 ? 35.401 63.871 6.410 1.00 25.71 ? 445 ARG A O 1 ATOM 3539 C CB . ARG A 1 445 ? 35.516 63.981 9.192 1.00 27.31 ? 445 ARG A CB 1 ATOM 3540 C CG . ARG A 1 445 ? 35.800 64.552 10.576 1.00 30.09 ? 445 ARG A CG 1 ATOM 3541 C CD . ARG A 1 445 ? 36.985 63.846 11.206 1.00 32.33 ? 445 ARG A CD 1 ATOM 3542 N NE . ARG A 1 445 ? 36.600 62.738 12.074 1.00 32.94 ? 445 ARG A NE 1 ATOM 3543 C CZ . ARG A 1 445 ? 37.355 61.662 12.288 1.00 34.96 ? 445 ARG A CZ 1 ATOM 3544 N NH1 . ARG A 1 445 ? 38.533 61.543 11.683 1.00 33.65 ? 445 ARG A NH1 1 ATOM 3545 N NH2 . ARG A 1 445 ? 36.950 60.719 13.132 1.00 34.06 ? 445 ARG A NH2 1 ATOM 3546 N N . SER A 1 446 ? 33.169 64.168 6.421 1.00 24.80 ? 446 SER A N 1 ATOM 3547 C CA . SER A 1 446 ? 33.004 63.680 5.057 1.00 25.14 ? 446 SER A CA 1 ATOM 3548 C C . SER A 1 446 ? 33.670 64.581 4.030 1.00 25.48 ? 446 SER A C 1 ATOM 3549 O O . SER A 1 446 ? 33.948 64.146 2.911 1.00 26.23 ? 446 SER A O 1 ATOM 3550 C CB . SER A 1 446 ? 31.518 63.531 4.720 1.00 25.36 ? 446 SER A CB 1 ATOM 3551 O OG . SER A 1 446 ? 30.840 64.771 4.827 1.00 25.85 ? 446 SER A OG 1 ATOM 3552 N N . THR A 1 447 ? 33.931 65.831 4.405 1.00 24.57 ? 447 THR A N 1 ATOM 3553 C CA . THR A 1 447 ? 34.559 66.776 3.487 1.00 24.46 ? 447 THR A CA 1 ATOM 3554 C C . THR A 1 447 ? 35.227 67.926 4.228 1.00 26.18 ? 447 THR A C 1 ATOM 3555 O O . THR A 1 447 ? 34.816 68.282 5.332 1.00 26.98 ? 447 THR A O 1 ATOM 3556 C CB . THR A 1 447 ? 33.516 67.389 2.517 1.00 24.84 ? 447 THR A CB 1 ATOM 3557 O OG1 . THR A 1 447 ? 34.172 68.245 1.571 1.00 21.52 ? 447 THR A OG1 1 ATOM 3558 C CG2 . THR A 1 447 ? 32.486 68.209 3.295 1.00 22.30 ? 447 THR A CG2 1 ATOM 3559 N N . VAL A 1 448 ? 36.264 68.496 3.621 1.00 26.29 ? 448 VAL A N 1 ATOM 3560 C CA . VAL A 1 448 ? 36.948 69.640 4.212 1.00 28.41 ? 448 VAL A CA 1 ATOM 3561 C C . VAL A 1 448 ? 36.405 70.903 3.539 1.00 30.26 ? 448 VAL A C 1 ATOM 3562 O O . VAL A 1 448 ? 36.809 72.017 3.866 1.00 31.54 ? 448 VAL A O 1 ATOM 3563 C CB . VAL A 1 448 ? 38.486 69.577 4.012 1.00 27.81 ? 448 VAL A CB 1 ATOM 3564 C CG1 . VAL A 1 448 ? 39.052 68.369 4.733 1.00 25.71 ? 448 VAL A CG1 1 ATOM 3565 C CG2 . VAL A 1 448 ? 38.828 69.537 2.527 1.00 25.72 ? 448 VAL A CG2 1 ATOM 3566 N N . ARG A 1 449 ? 35.482 70.713 2.599 1.00 30.74 ? 449 ARG A N 1 ATOM 3567 C CA . ARG A 1 449 ? 34.866 71.825 1.882 1.00 31.46 ? 449 ARG A CA 1 ATOM 3568 C C . ARG A 1 449 ? 33.929 72.636 2.773 1.00 32.65 ? 449 ARG A C 1 ATOM 3569 O O . ARG A 1 449 ? 33.379 72.124 3.748 1.00 33.26 ? 449 ARG A O 1 ATOM 3570 C CB . ARG A 1 449 ? 34.075 71.314 0.678 1.00 30.87 ? 449 ARG A CB 1 ATOM 3571 C CG . ARG A 1 449 ? 34.915 70.972 -0.525 1.00 29.76 ? 449 ARG A CG 1 ATOM 3572 C CD . ARG A 1 449 ? 34.198 71.435 -1.772 1.00 32.08 ? 449 ARG A CD 1 ATOM 3573 N NE . ARG A 1 449 ? 33.297 70.430 -2.311 1.00 31.75 ? 449 ARG A NE 1 ATOM 3574 C CZ . ARG A 1 449 ? 32.204 70.710 -3.014 1.00 31.97 ? 449 ARG A CZ 1 ATOM 3575 N NH1 . ARG A 1 449 ? 31.868 71.972 -3.253 1.00 29.36 ? 449 ARG A NH1 1 ATOM 3576 N NH2 . ARG A 1 449 ? 31.462 69.725 -3.502 1.00 30.01 ? 449 ARG A NH2 1 ATOM 3577 N N . SER A 1 450 ? 33.744 73.904 2.423 1.00 33.71 ? 450 SER A N 1 ATOM 3578 C CA . SER A 1 450 ? 32.863 74.785 3.180 1.00 35.19 ? 450 SER A CA 1 ATOM 3579 C C . SER A 1 450 ? 31.481 74.827 2.539 1.00 34.20 ? 450 SER A C 1 ATOM 3580 O O . SER A 1 450 ? 31.318 74.486 1.367 1.00 34.12 ? 450 SER A O 1 ATOM 3581 C CB . SER A 1 450 ? 33.435 76.206 3.216 1.00 36.74 ? 450 SER A CB 1 ATOM 3582 O OG . SER A 1 450 ? 34.706 76.234 3.837 1.00 42.73 ? 450 SER A OG 1 ATOM 3583 N N . ASN A 1 451 ? 30.491 75.249 3.316 1.00 33.99 ? 451 ASN A N 1 ATOM 3584 C CA . ASN A 1 451 ? 29.121 75.366 2.829 1.00 34.66 ? 451 ASN A CA 1 ATOM 3585 C C . ASN A 1 451 ? 28.503 74.043 2.403 1.00 33.53 ? 451 ASN A C 1 ATOM 3586 O O . ASN A 1 451 ? 27.719 73.988 1.452 1.00 33.52 ? 451 ASN A O 1 ATOM 3587 C CB . ASN A 1 451 ? 29.064 76.359 1.668 1.00 36.84 ? 451 ASN A CB 1 ATOM 3588 C CG . ASN A 1 451 ? 29.670 77.698 2.028 1.00 40.02 ? 451 ASN A CG 1 ATOM 3589 O OD1 . ASN A 1 451 ? 29.289 78.314 3.026 1.00 41.68 ? 451 ASN A OD1 1 ATOM 3590 N ND2 . ASN A 1 451 ? 30.622 78.158 1.219 1.00 40.48 ? 451 ASN A ND2 1 ATOM 3591 N N . ILE A 1 452 ? 28.867 72.978 3.109 1.00 31.23 ? 452 ILE A N 1 ATOM 3592 C CA . ILE A 1 452 ? 28.327 71.655 2.839 1.00 28.49 ? 452 ILE A CA 1 ATOM 3593 C C . ILE A 1 452 ? 27.650 71.187 4.118 1.00 27.79 ? 452 ILE A C 1 ATOM 3594 O O . ILE A 1 452 ? 28.264 71.183 5.182 1.00 30.24 ? 452 ILE A O 1 ATOM 3595 C CB . ILE A 1 452 ? 29.436 70.648 2.468 1.00 28.35 ? 452 ILE A CB 1 ATOM 3596 C CG1 . ILE A 1 452 ? 30.180 71.127 1.217 1.00 27.22 ? 452 ILE A CG1 1 ATOM 3597 C CG2 . ILE A 1 452 ? 28.826 69.264 2.233 1.00 25.98 ? 452 ILE A CG2 1 ATOM 3598 C CD1 . ILE A 1 452 ? 29.306 71.232 -0.019 1.00 25.29 ? 452 ILE A CD1 1 ATOM 3599 N N . ASP A 1 453 ? 26.379 70.815 4.024 1.00 26.51 ? 453 ASP A N 1 ATOM 3600 C CA . ASP A 1 453 ? 25.650 70.341 5.192 1.00 24.82 ? 453 ASP A CA 1 ATOM 3601 C C . ASP A 1 453 ? 26.199 68.969 5.561 1.00 24.72 ? 453 ASP A C 1 ATOM 3602 O O . ASP A 1 453 ? 25.877 67.968 4.921 1.00 24.14 ? 453 ASP A O 1 ATOM 3603 C CB . ASP A 1 453 ? 24.161 70.230 4.881 1.00 24.92 ? 453 ASP A CB 1 ATOM 3604 C CG . ASP A 1 453 ? 23.353 69.770 6.077 1.00 28.28 ? 453 ASP A CG 1 ATOM 3605 O OD1 . ASP A 1 453 ? 23.959 69.293 7.060 1.00 28.34 ? 453 ASP A OD1 1 ATOM 3606 O OD2 . ASP A 1 453 ? 22.108 69.874 6.034 1.00 31.21 ? 453 ASP A OD2 1 ATOM 3607 N N . THR A 1 454 ? 27.030 68.929 6.596 1.00 24.59 ? 454 THR A N 1 ATOM 3608 C CA . THR A 1 454 ? 27.638 67.682 7.034 1.00 23.59 ? 454 THR A CA 1 ATOM 3609 C C . THR A 1 454 ? 26.972 67.095 8.270 1.00 24.52 ? 454 THR A C 1 ATOM 3610 O O . THR A 1 454 ? 27.601 66.357 9.035 1.00 24.33 ? 454 THR A O 1 ATOM 3611 C CB . THR A 1 454 ? 29.135 67.874 7.321 1.00 24.52 ? 454 THR A CB 1 ATOM 3612 O OG1 . THR A 1 454 ? 29.307 68.944 8.259 1.00 25.78 ? 454 THR A OG1 1 ATOM 3613 C CG2 . THR A 1 454 ? 29.887 68.196 6.035 1.00 23.45 ? 454 THR A CG2 1 ATOM 3614 N N . THR A 1 455 ? 25.699 67.426 8.464 1.00 23.36 ? 455 THR A N 1 ATOM 3615 C CA . THR A 1 455 ? 24.939 66.907 9.590 1.00 22.60 ? 455 THR A CA 1 ATOM 3616 C C . THR A 1 455 ? 24.954 65.375 9.527 1.00 23.80 ? 455 THR A C 1 ATOM 3617 O O . THR A 1 455 ? 24.842 64.789 8.444 1.00 22.34 ? 455 THR A O 1 ATOM 3618 C CB . THR A 1 455 ? 23.475 67.380 9.523 1.00 23.97 ? 455 THR A CB 1 ATOM 3619 O OG1 . THR A 1 455 ? 23.438 68.810 9.571 1.00 27.30 ? 455 THR A OG1 1 ATOM 3620 C CG2 . THR A 1 455 ? 22.666 66.810 10.684 1.00 21.01 ? 455 THR A CG2 1 ATOM 3621 N N . SER A 1 456 ? 25.090 64.732 10.684 1.00 21.28 ? 456 SER A N 1 ATOM 3622 C CA . SER A 1 456 ? 25.106 63.276 10.748 1.00 21.64 ? 456 SER A CA 1 ATOM 3623 C C . SER A 1 456 ? 23.701 62.729 10.993 1.00 21.31 ? 456 SER A C 1 ATOM 3624 O O . SER A 1 456 ? 22.810 63.457 11.428 1.00 21.69 ? 456 SER A O 1 ATOM 3625 C CB . SER A 1 456 ? 26.057 62.807 11.853 1.00 21.40 ? 456 SER A CB 1 ATOM 3626 O OG . SER A 1 456 ? 27.401 63.137 11.530 1.00 24.37 ? 456 SER A OG 1 ATOM 3627 N N . TYR A 1 457 ? 23.508 61.445 10.706 1.00 19.63 ? 457 TYR A N 1 ATOM 3628 C CA . TYR A 1 457 ? 22.209 60.803 10.883 1.00 19.58 ? 457 TYR A CA 1 ATOM 3629 C C . TYR A 1 457 ? 22.371 59.515 11.676 1.00 19.59 ? 457 TYR A C 1 ATOM 3630 O O . TYR A 1 457 ? 23.428 58.887 11.653 1.00 21.32 ? 457 TYR A O 1 ATOM 3631 C CB . TYR A 1 457 ? 21.587 60.492 9.511 1.00 19.50 ? 457 TYR A CB 1 ATOM 3632 C CG . TYR A 1 457 ? 21.527 61.701 8.613 1.00 20.54 ? 457 TYR A CG 1 ATOM 3633 C CD1 . TYR A 1 457 ? 20.653 62.753 8.888 1.00 20.33 ? 457 TYR A CD1 1 ATOM 3634 C CD2 . TYR A 1 457 ? 22.415 61.845 7.546 1.00 20.85 ? 457 TYR A CD2 1 ATOM 3635 C CE1 . TYR A 1 457 ? 20.671 63.924 8.129 1.00 20.26 ? 457 TYR A CE1 1 ATOM 3636 C CE2 . TYR A 1 457 ? 22.443 63.015 6.778 1.00 20.33 ? 457 TYR A CE2 1 ATOM 3637 C CZ . TYR A 1 457 ? 21.572 64.050 7.080 1.00 21.31 ? 457 TYR A CZ 1 ATOM 3638 O OH . TYR A 1 457 ? 21.626 65.226 6.363 1.00 22.61 ? 457 TYR A OH 1 ATOM 3639 N N . GLY A 1 458 ? 21.315 59.123 12.373 1.00 19.92 ? 458 GLY A N 1 ATOM 3640 C CA . GLY A 1 458 ? 21.363 57.909 13.161 1.00 20.51 ? 458 GLY A CA 1 ATOM 3641 C C . GLY A 1 458 ? 19.974 57.389 13.481 1.00 22.23 ? 458 GLY A C 1 ATOM 3642 O O . GLY A 1 458 ? 18.977 58.103 13.347 1.00 21.97 ? 458 GLY A O 1 ATOM 3643 N N . ALA A 1 459 ? 19.910 56.133 13.903 1.00 21.32 ? 459 ALA A N 1 ATOM 3644 C CA . ALA A 1 459 ? 18.648 55.507 14.251 1.00 22.31 ? 459 ALA A CA 1 ATOM 3645 C C . ALA A 1 459 ? 18.944 54.239 15.030 1.00 23.30 ? 459 ALA A C 1 ATOM 3646 O O . ALA A 1 459 ? 20.047 53.692 14.939 1.00 24.22 ? 459 ALA A O 1 ATOM 3647 C CB . ALA A 1 459 ? 17.864 55.174 12.990 1.00 21.75 ? 459 ALA A CB 1 ATOM 3648 N N . PHE A 1 460 ? 17.972 53.783 15.811 1.00 23.68 ? 460 PHE A N 1 ATOM 3649 C CA . PHE A 1 460 ? 18.146 52.558 16.572 1.00 26.40 ? 460 PHE A CA 1 ATOM 3650 C C . PHE A 1 460 ? 17.744 51.384 15.691 1.00 27.79 ? 460 PHE A C 1 ATOM 3651 O O . PHE A 1 460 ? 16.809 51.489 14.896 1.00 30.50 ? 460 PHE A O 1 ATOM 3652 C CB . PHE A 1 460 ? 17.310 52.593 17.852 1.00 25.07 ? 460 PHE A CB 1 ATOM 3653 C CG . PHE A 1 460 ? 17.852 53.529 18.887 1.00 25.43 ? 460 PHE A CG 1 ATOM 3654 C CD1 . PHE A 1 460 ? 17.211 54.728 19.170 1.00 25.87 ? 460 PHE A CD1 1 ATOM 3655 C CD2 . PHE A 1 460 ? 19.045 53.234 19.541 1.00 26.87 ? 460 PHE A CD2 1 ATOM 3656 C CE1 . PHE A 1 460 ? 17.753 55.627 20.088 1.00 28.18 ? 460 PHE A CE1 1 ATOM 3657 C CE2 . PHE A 1 460 ? 19.597 54.125 20.462 1.00 28.18 ? 460 PHE A CE2 1 ATOM 3658 C CZ . PHE A 1 460 ? 18.950 55.324 20.736 1.00 28.20 ? 460 PHE A CZ 1 ATOM 3659 N N . VAL A 1 461 ? 18.479 50.283 15.814 1.00 28.43 ? 461 VAL A N 1 ATOM 3660 C CA . VAL A 1 461 ? 18.218 49.080 15.028 1.00 27.32 ? 461 VAL A CA 1 ATOM 3661 C C . VAL A 1 461 ? 17.521 48.079 15.935 1.00 29.48 ? 461 VAL A C 1 ATOM 3662 O O . VAL A 1 461 ? 18.017 47.761 17.017 1.00 30.80 ? 461 VAL A O 1 ATOM 3663 C CB . VAL A 1 461 ? 19.534 48.455 14.517 1.00 25.36 ? 461 VAL A CB 1 ATOM 3664 C CG1 . VAL A 1 461 ? 19.232 47.307 13.576 1.00 24.21 ? 461 VAL A CG1 1 ATOM 3665 C CG2 . VAL A 1 461 ? 20.387 49.513 13.834 1.00 23.19 ? 461 VAL A CG2 1 ATOM 3666 N N . ASP A 1 462 ? 16.373 47.577 15.497 1.00 31.73 ? 462 ASP A N 1 ATOM 3667 C CA . ASP A 1 462 ? 15.623 46.631 16.309 1.00 32.49 ? 462 ASP A CA 1 ATOM 3668 C C . ASP A 1 462 ? 16.071 45.183 16.179 1.00 33.10 ? 462 ASP A C 1 ATOM 3669 O O . ASP A 1 462 ? 15.407 44.376 15.527 1.00 33.17 ? 462 ASP A O 1 ATOM 3670 C CB . ASP A 1 462 ? 14.134 46.712 15.982 1.00 35.61 ? 462 ASP A CB 1 ATOM 3671 C CG . ASP A 1 462 ? 13.288 45.864 16.920 1.00 39.10 ? 462 ASP A CG 1 ATOM 3672 O OD1 . ASP A 1 462 ? 12.095 45.653 16.622 1.00 41.69 ? 462 ASP A OD1 1 ATOM 3673 O OD2 . ASP A 1 462 ? 13.816 45.415 17.962 1.00 40.74 ? 462 ASP A OD2 1 ATOM 3674 N N . ILE A 1 463 ? 17.199 44.856 16.801 1.00 33.56 ? 463 ILE A N 1 ATOM 3675 C CA . ILE A 1 463 ? 17.710 43.492 16.791 1.00 32.66 ? 463 ILE A CA 1 ATOM 3676 C C . ILE A 1 463 ? 18.225 43.154 18.182 1.00 32.60 ? 463 ILE A C 1 ATOM 3677 O O . ILE A 1 463 ? 18.480 44.046 18.993 1.00 33.08 ? 463 ILE A O 1 ATOM 3678 C CB . ILE A 1 463 ? 18.865 43.299 15.780 1.00 33.42 ? 463 ILE A CB 1 ATOM 3679 C CG1 . ILE A 1 463 ? 19.989 44.295 16.061 1.00 32.88 ? 463 ILE A CG1 1 ATOM 3680 C CG2 . ILE A 1 463 ? 18.347 43.449 14.366 1.00 33.31 ? 463 ILE A CG2 1 ATOM 3681 C CD1 . ILE A 1 463 ? 21.167 44.152 15.122 1.00 33.81 ? 463 ILE A CD1 1 ATOM 3682 N N . ASP A 1 464 ? 18.359 41.861 18.456 1.00 32.14 ? 464 ASP A N 1 ATOM 3683 C CA . ASP A 1 464 ? 18.862 41.391 19.739 1.00 31.39 ? 464 ASP A CA 1 ATOM 3684 C C . ASP A 1 464 ? 20.303 40.934 19.507 1.00 30.69 ? 464 ASP A C 1 ATOM 3685 O O . ASP A 1 464 ? 20.540 39.857 18.958 1.00 30.19 ? 464 ASP A O 1 ATOM 3686 C CB . ASP A 1 464 ? 17.991 40.237 20.240 1.00 33.10 ? 464 ASP A CB 1 ATOM 3687 C CG . ASP A 1 464 ? 18.472 39.663 21.562 1.00 35.29 ? 464 ASP A CG 1 ATOM 3688 O OD1 . ASP A 1 464 ? 19.327 40.292 22.229 1.00 34.03 ? 464 ASP A OD1 1 ATOM 3689 O OD2 . ASP A 1 464 ? 17.981 38.575 21.934 1.00 37.22 ? 464 ASP A OD2 1 ATOM 3690 N N . PRO A 1 465 ? 21.284 41.754 19.926 1.00 30.26 ? 465 PRO A N 1 ATOM 3691 C CA . PRO A 1 465 ? 22.717 41.473 19.773 1.00 30.32 ? 465 PRO A CA 1 ATOM 3692 C C . PRO A 1 465 ? 23.148 40.125 20.347 1.00 31.38 ? 465 PRO A C 1 ATOM 3693 O O . PRO A 1 465 ? 24.189 39.591 19.971 1.00 31.70 ? 465 PRO A O 1 ATOM 3694 C CB . PRO A 1 465 ? 23.388 42.636 20.513 1.00 29.73 ? 465 PRO A CB 1 ATOM 3695 C CG . PRO A 1 465 ? 22.347 43.698 20.558 1.00 28.75 ? 465 PRO A CG 1 ATOM 3696 C CD . PRO A 1 465 ? 21.082 42.934 20.785 1.00 28.37 ? 465 PRO A CD 1 ATOM 3697 N N . ARG A 1 466 ? 22.354 39.584 21.265 1.00 32.33 ? 466 ARG A N 1 ATOM 3698 C CA . ARG A 1 466 ? 22.683 38.307 21.891 1.00 34.16 ? 466 ARG A CA 1 ATOM 3699 C C . ARG A 1 466 ? 22.569 37.124 20.941 1.00 35.73 ? 466 ARG A C 1 ATOM 3700 O O . ARG A 1 466 ? 23.329 36.165 21.054 1.00 37.65 ? 466 ARG A O 1 ATOM 3701 C CB . ARG A 1 466 ? 21.783 38.056 23.105 1.00 32.31 ? 466 ARG A CB 1 ATOM 3702 C CG . ARG A 1 466 ? 22.011 39.005 24.270 1.00 34.63 ? 466 ARG A CG 1 ATOM 3703 C CD . ARG A 1 466 ? 20.968 38.787 25.349 1.00 34.31 ? 466 ARG A CD 1 ATOM 3704 N NE . ARG A 1 466 ? 19.616 38.906 24.811 1.00 34.04 ? 466 ARG A NE 1 ATOM 3705 C CZ . ARG A 1 466 ? 18.512 38.615 25.491 1.00 36.51 ? 466 ARG A CZ 1 ATOM 3706 N NH1 . ARG A 1 466 ? 18.594 38.186 26.746 1.00 36.43 ? 466 ARG A NH1 1 ATOM 3707 N NH2 . ARG A 1 466 ? 17.322 38.740 24.913 1.00 35.21 ? 466 ARG A NH2 1 ATOM 3708 N N . SER A 1 467 ? 21.631 37.186 20.003 1.00 35.94 ? 467 SER A N 1 ATOM 3709 C CA . SER A 1 467 ? 21.442 36.076 19.079 1.00 37.52 ? 467 SER A CA 1 ATOM 3710 C C . SER A 1 467 ? 21.540 36.435 17.600 1.00 37.85 ? 467 SER A C 1 ATOM 3711 O O . SER A 1 467 ? 21.364 35.576 16.741 1.00 38.01 ? 467 SER A O 1 ATOM 3712 C CB . SER A 1 467 ? 20.095 35.412 19.352 1.00 36.86 ? 467 SER A CB 1 ATOM 3713 O OG . SER A 1 467 ? 19.042 36.347 19.230 1.00 40.75 ? 467 SER A OG 1 ATOM 3714 N N . GLU A 1 468 ? 21.819 37.698 17.304 1.00 38.99 ? 468 GLU A N 1 ATOM 3715 C CA . GLU A 1 468 ? 21.933 38.149 15.921 1.00 37.60 ? 468 GLU A CA 1 ATOM 3716 C C . GLU A 1 468 ? 23.189 38.969 15.714 1.00 35.51 ? 468 GLU A C 1 ATOM 3717 O O . GLU A 1 468 ? 23.449 39.903 16.470 1.00 35.25 ? 468 GLU A O 1 ATOM 3718 C CB . GLU A 1 468 ? 20.746 39.030 15.540 1.00 39.49 ? 468 GLU A CB 1 ATOM 3719 C CG . GLU A 1 468 ? 19.456 38.313 15.244 1.00 45.72 ? 468 GLU A CG 1 ATOM 3720 C CD . GLU A 1 468 ? 18.312 39.293 15.011 1.00 49.68 ? 468 GLU A CD 1 ATOM 3721 O OE1 . GLU A 1 468 ? 17.769 39.826 16.013 1.00 47.82 ? 468 GLU A OE1 1 ATOM 3722 O OE2 . GLU A 1 468 ? 17.973 39.539 13.828 1.00 49.40 ? 468 GLU A OE2 1 ATOM 3723 N N . GLU A 1 469 ? 23.965 38.628 14.692 1.00 33.37 ? 469 GLU A N 1 ATOM 3724 C CA . GLU A 1 469 ? 25.158 39.402 14.390 1.00 31.92 ? 469 GLU A CA 1 ATOM 3725 C C . GLU A 1 469 ? 24.643 40.688 13.764 1.00 30.13 ? 469 GLU A C 1 ATOM 3726 O O . GLU A 1 469 ? 23.589 40.695 13.129 1.00 29.80 ? 469 GLU A O 1 ATOM 3727 C CB . GLU A 1 469 ? 26.055 38.667 13.393 1.00 34.03 ? 469 GLU A CB 1 ATOM 3728 C CG . GLU A 1 469 ? 26.727 37.426 13.959 1.00 36.46 ? 469 GLU A CG 1 ATOM 3729 C CD . GLU A 1 469 ? 27.760 36.839 13.015 1.00 38.72 ? 469 GLU A CD 1 ATOM 3730 O OE1 . GLU A 1 469 ? 28.366 35.807 13.369 1.00 39.92 ? 469 GLU A OE1 1 ATOM 3731 O OE2 . GLU A 1 469 ? 27.969 37.411 11.922 1.00 40.00 ? 469 GLU A OE2 1 ATOM 3732 N N . ILE A 1 470 ? 25.370 41.778 13.952 1.00 28.67 ? 470 ILE A N 1 ATOM 3733 C CA . ILE A 1 470 ? 24.960 43.052 13.390 1.00 26.71 ? 470 ILE A CA 1 ATOM 3734 C C . ILE A 1 470 ? 25.476 43.150 11.959 1.00 27.22 ? 470 ILE A C 1 ATOM 3735 O O . ILE A 1 470 ? 26.686 43.157 11.731 1.00 27.49 ? 470 ILE A O 1 ATOM 3736 C CB . ILE A 1 470 ? 25.520 44.199 14.227 1.00 26.11 ? 470 ILE A CB 1 ATOM 3737 C CG1 . ILE A 1 470 ? 25.091 44.006 15.684 1.00 27.92 ? 470 ILE A CG1 1 ATOM 3738 C CG2 . ILE A 1 470 ? 25.030 45.528 13.685 1.00 25.43 ? 470 ILE A CG2 1 ATOM 3739 C CD1 . ILE A 1 470 ? 25.662 45.024 16.645 1.00 28.27 ? 470 ILE A CD1 1 ATOM 3740 N N . SER A 1 471 ? 24.563 43.214 10.994 1.00 25.38 ? 471 SER A N 1 ATOM 3741 C CA . SER A 1 471 ? 24.968 43.297 9.597 1.00 25.29 ? 471 SER A CA 1 ATOM 3742 C C . SER A 1 471 ? 24.713 44.671 8.994 1.00 24.15 ? 471 SER A C 1 ATOM 3743 O O . SER A 1 471 ? 23.787 45.383 9.390 1.00 22.93 ? 471 SER A O 1 ATOM 3744 C CB . SER A 1 471 ? 24.249 42.232 8.764 1.00 24.75 ? 471 SER A CB 1 ATOM 3745 O OG . SER A 1 471 ? 22.865 42.509 8.676 1.00 29.59 ? 471 SER A OG 1 ATOM 3746 N N . LEU A 1 472 ? 25.540 45.027 8.016 1.00 23.32 ? 472 LEU A N 1 ATOM 3747 C CA . LEU A 1 472 ? 25.438 46.313 7.354 1.00 22.84 ? 472 LEU A CA 1 ATOM 3748 C C . LEU A 1 472 ? 25.789 46.236 5.874 1.00 23.37 ? 472 LEU A C 1 ATOM 3749 O O . LEU A 1 472 ? 26.847 45.725 5.510 1.00 24.73 ? 472 LEU A O 1 ATOM 3750 C CB . LEU A 1 472 ? 26.375 47.315 8.034 1.00 22.20 ? 472 LEU A CB 1 ATOM 3751 C CG . LEU A 1 472 ? 26.564 48.676 7.362 1.00 21.74 ? 472 LEU A CG 1 ATOM 3752 C CD1 . LEU A 1 472 ? 25.265 49.478 7.436 1.00 20.00 ? 472 LEU A CD1 1 ATOM 3753 C CD2 . LEU A 1 472 ? 27.700 49.421 8.050 1.00 20.24 ? 472 LEU A CD2 1 ATOM 3754 N N . ARG A 1 473 ? 24.900 46.744 5.025 1.00 22.25 ? 473 ARG A N 1 ATOM 3755 C CA . ARG A 1 473 ? 25.153 46.770 3.591 1.00 21.78 ? 473 ARG A CA 1 ATOM 3756 C C . ARG A 1 473 ? 25.230 48.229 3.155 1.00 23.01 ? 473 ARG A C 1 ATOM 3757 O O . ARG A 1 473 ? 24.428 49.059 3.585 1.00 24.71 ? 473 ARG A O 1 ATOM 3758 C CB . ARG A 1 473 ? 24.043 46.062 2.810 1.00 20.78 ? 473 ARG A CB 1 ATOM 3759 C CG . ARG A 1 473 ? 24.288 46.055 1.302 1.00 18.51 ? 473 ARG A CG 1 ATOM 3760 C CD . ARG A 1 473 ? 23.200 45.304 0.545 1.00 18.70 ? 473 ARG A CD 1 ATOM 3761 N NE . ARG A 1 473 ? 23.350 45.410 -0.907 1.00 17.34 ? 473 ARG A NE 1 ATOM 3762 C CZ . ARG A 1 473 ? 22.443 44.977 -1.783 1.00 21.99 ? 473 ARG A CZ 1 ATOM 3763 N NH1 . ARG A 1 473 ? 21.320 44.405 -1.355 1.00 18.36 ? 473 ARG A NH1 1 ATOM 3764 N NH2 . ARG A 1 473 ? 22.646 45.129 -3.089 1.00 19.03 ? 473 ARG A NH2 1 ATOM 3765 N N . ASN A 1 474 ? 26.201 48.541 2.308 1.00 23.49 ? 474 ASN A N 1 ATOM 3766 C CA . ASN A 1 474 ? 26.375 49.900 1.826 1.00 22.42 ? 474 ASN A CA 1 ATOM 3767 C C . ASN A 1 474 ? 26.482 50.011 0.318 1.00 22.56 ? 474 ASN A C 1 ATOM 3768 O O . ASN A 1 474 ? 27.303 49.347 -0.321 1.00 22.44 ? 474 ASN A O 1 ATOM 3769 C CB . ASN A 1 474 ? 27.621 50.536 2.444 1.00 23.22 ? 474 ASN A CB 1 ATOM 3770 C CG . ASN A 1 474 ? 27.384 51.027 3.850 1.00 26.61 ? 474 ASN A CG 1 ATOM 3771 O OD1 . ASN A 1 474 ? 26.799 52.087 4.057 1.00 27.89 ? 474 ASN A OD1 1 ATOM 3772 N ND2 . ASN A 1 474 ? 27.827 50.247 4.833 1.00 29.13 ? 474 ASN A ND2 1 ATOM 3773 N N . LEU A 1 475 ? 25.634 50.862 -0.240 1.00 21.30 ? 475 LEU A N 1 ATOM 3774 C CA . LEU A 1 475 ? 25.643 51.137 -1.661 1.00 20.66 ? 475 LEU A CA 1 ATOM 3775 C C . LEU A 1 475 ? 26.450 52.434 -1.756 1.00 20.87 ? 475 LEU A C 1 ATOM 3776 O O . LEU A 1 475 ? 25.985 53.494 -1.345 1.00 22.57 ? 475 LEU A O 1 ATOM 3777 C CB . LEU A 1 475 ? 24.210 51.338 -2.161 1.00 19.43 ? 475 LEU A CB 1 ATOM 3778 C CG . LEU A 1 475 ? 23.613 50.256 -3.066 1.00 20.57 ? 475 LEU A CG 1 ATOM 3779 C CD1 . LEU A 1 475 ? 24.058 48.875 -2.623 1.00 20.33 ? 475 LEU A CD1 1 ATOM 3780 C CD2 . LEU A 1 475 ? 22.097 50.374 -3.064 1.00 16.72 ? 475 LEU A CD2 1 ATOM 3781 N N . ILE A 1 476 ? 27.677 52.334 -2.250 1.00 20.67 ? 476 ILE A N 1 ATOM 3782 C CA . ILE A 1 476 ? 28.543 53.495 -2.387 1.00 20.10 ? 476 ILE A CA 1 ATOM 3783 C C . ILE A 1 476 ? 28.546 53.923 -3.846 1.00 21.76 ? 476 ILE A C 1 ATOM 3784 O O . ILE A 1 476 ? 28.884 53.130 -4.731 1.00 22.50 ? 476 ILE A O 1 ATOM 3785 C CB . ILE A 1 476 ? 29.985 53.163 -1.963 1.00 20.62 ? 476 ILE A CB 1 ATOM 3786 C CG1 . ILE A 1 476 ? 29.998 52.655 -0.518 1.00 21.08 ? 476 ILE A CG1 1 ATOM 3787 C CG2 . ILE A 1 476 ? 30.863 54.399 -2.099 1.00 18.22 ? 476 ILE A CG2 1 ATOM 3788 C CD1 . ILE A 1 476 ? 31.364 52.177 -0.042 1.00 19.85 ? 476 ILE A CD1 1 ATOM 3789 N N . ASP A 1 477 ? 28.168 55.173 -4.099 1.00 22.07 ? 477 ASP A N 1 ATOM 3790 C CA . ASP A 1 477 ? 28.119 55.683 -5.464 1.00 21.79 ? 477 ASP A CA 1 ATOM 3791 C C . ASP A 1 477 ? 28.441 57.178 -5.517 1.00 23.03 ? 477 ASP A C 1 ATOM 3792 O O . ASP A 1 477 ? 27.548 58.019 -5.636 1.00 23.19 ? 477 ASP A O 1 ATOM 3793 C CB . ASP A 1 477 ? 26.734 55.419 -6.060 1.00 20.46 ? 477 ASP A CB 1 ATOM 3794 C CG . ASP A 1 477 ? 26.719 55.512 -7.575 1.00 22.58 ? 477 ASP A CG 1 ATOM 3795 O OD1 . ASP A 1 477 ? 25.637 55.319 -8.172 1.00 22.35 ? 477 ASP A OD1 1 ATOM 3796 O OD2 . ASP A 1 477 ? 27.786 55.772 -8.172 1.00 22.33 ? 477 ASP A OD2 1 ATOM 3797 N N . HIS A 1 478 ? 29.728 57.493 -5.407 1.00 22.76 ? 478 HIS A N 1 ATOM 3798 C CA . HIS A 1 478 ? 30.221 58.864 -5.457 1.00 22.47 ? 478 HIS A CA 1 ATOM 3799 C C . HIS A 1 478 ? 29.666 59.832 -4.414 1.00 22.58 ? 478 HIS A C 1 ATOM 3800 O O . HIS A 1 478 ? 30.135 59.841 -3.283 1.00 24.20 ? 478 HIS A O 1 ATOM 3801 C CB . HIS A 1 478 ? 30.026 59.421 -6.867 1.00 22.09 ? 478 HIS A CB 1 ATOM 3802 C CG . HIS A 1 478 ? 30.745 58.631 -7.917 1.00 24.99 ? 478 HIS A CG 1 ATOM 3803 N ND1 . HIS A 1 478 ? 30.312 57.393 -8.343 1.00 25.78 ? 478 HIS A ND1 1 ATOM 3804 C CD2 . HIS A 1 478 ? 31.904 58.872 -8.577 1.00 24.68 ? 478 HIS A CD2 1 ATOM 3805 C CE1 . HIS A 1 478 ? 31.173 56.905 -9.219 1.00 24.90 ? 478 HIS A CE1 1 ATOM 3806 N NE2 . HIS A 1 478 ? 32.148 57.782 -9.378 1.00 24.75 ? 478 HIS A NE2 1 ATOM 3807 N N . SER A 1 479 ? 28.683 60.652 -4.771 1.00 22.78 ? 479 SER A N 1 ATOM 3808 C CA . SER A 1 479 ? 28.147 61.608 -3.806 1.00 22.08 ? 479 SER A CA 1 ATOM 3809 C C . SER A 1 479 ? 26.975 61.090 -2.983 1.00 22.82 ? 479 SER A C 1 ATOM 3810 O O . SER A 1 479 ? 26.335 61.858 -2.264 1.00 22.50 ? 479 SER A O 1 ATOM 3811 C CB . SER A 1 479 ? 27.746 62.916 -4.497 1.00 23.03 ? 479 SER A CB 1 ATOM 3812 O OG . SER A 1 479 ? 26.640 62.734 -5.360 1.00 22.19 ? 479 SER A OG 1 ATOM 3813 N N . ILE A 1 480 ? 26.684 59.795 -3.091 1.00 22.13 ? 480 ILE A N 1 ATOM 3814 C CA . ILE A 1 480 ? 25.607 59.201 -2.302 1.00 20.38 ? 480 ILE A CA 1 ATOM 3815 C C . ILE A 1 480 ? 26.021 57.852 -1.731 1.00 21.68 ? 480 ILE A C 1 ATOM 3816 O O . ILE A 1 480 ? 26.723 57.071 -2.384 1.00 22.79 ? 480 ILE A O 1 ATOM 3817 C CB . ILE A 1 480 ? 24.305 58.988 -3.127 1.00 20.33 ? 480 ILE A CB 1 ATOM 3818 C CG1 . ILE A 1 480 ? 23.172 58.533 -2.195 1.00 18.05 ? 480 ILE A CG1 1 ATOM 3819 C CG2 . ILE A 1 480 ? 24.523 57.935 -4.206 1.00 17.69 ? 480 ILE A CG2 1 ATOM 3820 C CD1 . ILE A 1 480 ? 21.785 58.488 -2.845 1.00 15.82 ? 480 ILE A CD1 1 ATOM 3821 N N . ILE A 1 481 ? 25.585 57.593 -0.504 1.00 20.81 ? 481 ILE A N 1 ATOM 3822 C CA . ILE A 1 481 ? 25.848 56.332 0.173 1.00 20.17 ? 481 ILE A CA 1 ATOM 3823 C C . ILE A 1 481 ? 24.530 55.884 0.798 1.00 21.32 ? 481 ILE A C 1 ATOM 3824 O O . ILE A 1 481 ? 23.899 56.645 1.535 1.00 22.11 ? 481 ILE A O 1 ATOM 3825 C CB . ILE A 1 481 ? 26.884 56.492 1.311 1.00 20.58 ? 481 ILE A CB 1 ATOM 3826 C CG1 . ILE A 1 481 ? 28.238 56.898 0.736 1.00 19.16 ? 481 ILE A CG1 1 ATOM 3827 C CG2 . ILE A 1 481 ? 27.010 55.184 2.092 1.00 18.13 ? 481 ILE A CG2 1 ATOM 3828 C CD1 . ILE A 1 481 ? 29.253 57.253 1.797 1.00 19.11 ? 481 ILE A CD1 1 ATOM 3829 N N . GLU A 1 482 ? 24.100 54.665 0.494 1.00 21.83 ? 482 GLU A N 1 ATOM 3830 C CA . GLU A 1 482 ? 22.867 54.149 1.079 1.00 22.12 ? 482 GLU A CA 1 ATOM 3831 C C . GLU A 1 482 ? 23.226 53.000 2.010 1.00 22.98 ? 482 GLU A C 1 ATOM 3832 O O . GLU A 1 482 ? 23.797 51.991 1.586 1.00 22.76 ? 482 GLU A O 1 ATOM 3833 C CB . GLU A 1 482 ? 21.899 53.695 -0.011 1.00 20.83 ? 482 GLU A CB 1 ATOM 3834 C CG . GLU A 1 482 ? 21.405 54.846 -0.865 1.00 23.36 ? 482 GLU A CG 1 ATOM 3835 C CD . GLU A 1 482 ? 20.384 54.414 -1.889 1.00 24.29 ? 482 GLU A CD 1 ATOM 3836 O OE1 . GLU A 1 482 ? 19.292 53.973 -1.484 1.00 24.27 ? 482 GLU A OE1 1 ATOM 3837 O OE2 . GLU A 1 482 ? 20.674 54.513 -3.097 1.00 24.38 ? 482 GLU A OE2 1 ATOM 3838 N N . SER A 1 483 ? 22.890 53.170 3.284 1.00 22.50 ? 483 SER A N 1 ATOM 3839 C CA . SER A 1 483 ? 23.202 52.186 4.309 1.00 21.37 ? 483 SER A CA 1 ATOM 3840 C C . SER A 1 483 ? 21.985 51.424 4.819 1.00 21.69 ? 483 SER A C 1 ATOM 3841 O O . SER A 1 483 ? 20.986 52.021 5.230 1.00 20.42 ? 483 SER A O 1 ATOM 3842 C CB . SER A 1 483 ? 23.890 52.887 5.479 1.00 20.29 ? 483 SER A CB 1 ATOM 3843 O OG . SER A 1 483 ? 24.917 53.744 5.012 1.00 22.37 ? 483 SER A OG 1 ATOM 3844 N N . PHE A 1 484 ? 22.094 50.098 4.802 1.00 21.36 ? 484 PHE A N 1 ATOM 3845 C CA . PHE A 1 484 ? 21.027 49.215 5.256 1.00 20.76 ? 484 PHE A CA 1 ATOM 3846 C C . PHE A 1 484 ? 21.520 48.373 6.430 1.00 21.95 ? 484 PHE A C 1 ATOM 3847 O O . PHE A 1 484 ? 22.365 47.488 6.264 1.00 22.50 ? 484 PHE A O 1 ATOM 3848 C CB . PHE A 1 484 ? 20.594 48.284 4.122 1.00 19.94 ? 484 PHE A CB 1 ATOM 3849 C CG . PHE A 1 484 ? 20.093 49.003 2.900 1.00 19.71 ? 484 PHE A CG 1 ATOM 3850 C CD1 . PHE A 1 484 ? 18.734 49.246 2.726 1.00 20.49 ? 484 PHE A CD1 1 ATOM 3851 C CD2 . PHE A 1 484 ? 20.984 49.444 1.924 1.00 19.90 ? 484 PHE A CD2 1 ATOM 3852 C CE1 . PHE A 1 484 ? 18.263 49.920 1.595 1.00 20.87 ? 484 PHE A CE1 1 ATOM 3853 C CE2 . PHE A 1 484 ? 20.528 50.119 0.789 1.00 22.38 ? 484 PHE A CE2 1 ATOM 3854 C CZ . PHE A 1 484 ? 19.164 50.358 0.624 1.00 21.86 ? 484 PHE A CZ 1 ATOM 3855 N N . GLY A 1 485 ? 20.998 48.654 7.618 1.00 20.86 ? 485 GLY A N 1 ATOM 3856 C CA . GLY A 1 485 ? 21.397 47.892 8.780 1.00 18.76 ? 485 GLY A CA 1 ATOM 3857 C C . GLY A 1 485 ? 20.436 46.742 9.017 1.00 19.73 ? 485 GLY A C 1 ATOM 3858 O O . GLY A 1 485 ? 19.239 46.855 8.749 1.00 18.73 ? 485 GLY A O 1 ATOM 3859 N N . ALA A 1 486 ? 20.967 45.624 9.503 1.00 19.17 ? 486 ALA A N 1 ATOM 3860 C CA . ALA A 1 486 ? 20.157 44.452 9.803 1.00 19.45 ? 486 ALA A CA 1 ATOM 3861 C C . ALA A 1 486 ? 19.191 44.044 8.692 1.00 19.85 ? 486 ALA A C 1 ATOM 3862 O O . ALA A 1 486 ? 17.989 43.907 8.925 1.00 20.68 ? 486 ALA A O 1 ATOM 3863 C CB . ALA A 1 486 ? 19.382 44.684 11.109 1.00 16.84 ? 486 ALA A CB 1 ATOM 3864 N N . GLY A 1 487 ? 19.717 43.849 7.488 1.00 20.35 ? 487 GLY A N 1 ATOM 3865 C CA . GLY A 1 487 ? 18.884 43.429 6.373 1.00 18.63 ? 487 GLY A CA 1 ATOM 3866 C C . GLY A 1 487 ? 17.822 44.406 5.896 1.00 19.64 ? 487 GLY A C 1 ATOM 3867 O O . GLY A 1 487 ? 16.884 44.014 5.205 1.00 19.87 ? 487 GLY A O 1 ATOM 3868 N N . GLY A 1 488 ? 17.957 45.676 6.252 1.00 18.94 ? 488 GLY A N 1 ATOM 3869 C CA . GLY A 1 488 ? 16.979 46.650 5.815 1.00 19.79 ? 488 GLY A CA 1 ATOM 3870 C C . GLY A 1 488 ? 16.011 47.101 6.894 1.00 21.31 ? 488 GLY A C 1 ATOM 3871 O O . GLY A 1 488 ? 15.001 47.740 6.586 1.00 21.71 ? 488 GLY A O 1 ATOM 3872 N N . LYS A 1 489 ? 16.295 46.767 8.152 1.00 20.15 ? 489 LYS A N 1 ATOM 3873 C CA . LYS A 1 489 ? 15.423 47.192 9.241 1.00 20.74 ? 489 LYS A CA 1 ATOM 3874 C C . LYS A 1 489 ? 15.637 48.677 9.506 1.00 21.00 ? 489 LYS A C 1 ATOM 3875 O O . LYS A 1 489 ? 14.710 49.385 9.914 1.00 21.12 ? 489 LYS A O 1 ATOM 3876 C CB . LYS A 1 489 ? 15.705 46.403 10.523 1.00 20.44 ? 489 LYS A CB 1 ATOM 3877 C CG . LYS A 1 489 ? 14.972 45.075 10.623 1.00 23.06 ? 489 LYS A CG 1 ATOM 3878 C CD . LYS A 1 489 ? 15.173 44.441 11.995 1.00 26.42 ? 489 LYS A CD 1 ATOM 3879 C CE . LYS A 1 489 ? 14.385 43.145 12.131 1.00 29.86 ? 489 LYS A CE 1 ATOM 3880 N NZ . LYS A 1 489 ? 14.504 42.549 13.493 1.00 31.46 ? 489 LYS A NZ 1 ATOM 3881 N N . THR A 1 490 ? 16.861 49.142 9.264 1.00 20.19 ? 490 THR A N 1 ATOM 3882 C CA . THR A 1 490 ? 17.213 50.542 9.479 1.00 21.03 ? 490 THR A CA 1 ATOM 3883 C C . THR A 1 490 ? 17.996 51.081 8.288 1.00 21.68 ? 490 THR A C 1 ATOM 3884 O O . THR A 1 490 ? 19.115 50.636 8.016 1.00 23.38 ? 490 THR A O 1 ATOM 3885 C CB . THR A 1 490 ? 18.067 50.704 10.748 1.00 21.08 ? 490 THR A CB 1 ATOM 3886 O OG1 . THR A 1 490 ? 17.377 50.122 11.860 1.00 22.93 ? 490 THR A OG1 1 ATOM 3887 C CG2 . THR A 1 490 ? 18.327 52.177 11.032 1.00 21.25 ? 490 THR A CG2 1 ATOM 3888 N N . CYS A 1 491 ? 17.413 52.045 7.585 1.00 19.21 ? 491 CYS A N 1 ATOM 3889 C CA . CYS A 1 491 ? 18.067 52.618 6.418 1.00 20.14 ? 491 CYS A CA 1 ATOM 3890 C C . CYS A 1 491 ? 18.429 54.088 6.612 1.00 20.94 ? 491 CYS A C 1 ATOM 3891 O O . CYS A 1 491 ? 17.682 54.854 7.228 1.00 20.93 ? 491 CYS A O 1 ATOM 3892 C CB . CYS A 1 491 ? 17.159 52.461 5.197 1.00 19.54 ? 491 CYS A CB 1 ATOM 3893 S SG . CYS A 1 491 ? 16.520 50.775 4.993 1.00 20.60 ? 491 CYS A SG 1 ATOM 3894 N N . ILE A 1 492 ? 19.586 54.473 6.081 1.00 20.20 ? 492 ILE A N 1 ATOM 3895 C CA . ILE A 1 492 ? 20.062 55.847 6.181 1.00 18.93 ? 492 ILE A CA 1 ATOM 3896 C C . ILE A 1 492 ? 20.784 56.221 4.896 1.00 19.79 ? 492 ILE A C 1 ATOM 3897 O O . ILE A 1 492 ? 21.804 55.619 4.557 1.00 21.02 ? 492 ILE A O 1 ATOM 3898 C CB . ILE A 1 492 ? 21.065 56.025 7.339 1.00 18.41 ? 492 ILE A CB 1 ATOM 3899 C CG1 . ILE A 1 492 ? 20.442 55.578 8.663 1.00 18.04 ? 492 ILE A CG1 1 ATOM 3900 C CG2 . ILE A 1 492 ? 21.489 57.480 7.425 1.00 17.82 ? 492 ILE A CG2 1 ATOM 3901 C CD1 . ILE A 1 492 ? 21.396 55.684 9.853 1.00 17.74 ? 492 ILE A CD1 1 ATOM 3902 N N . THR A 1 493 ? 20.259 57.214 4.187 1.00 17.88 ? 493 THR A N 1 ATOM 3903 C CA . THR A 1 493 ? 20.867 57.670 2.942 1.00 18.10 ? 493 THR A CA 1 ATOM 3904 C C . THR A 1 493 ? 21.690 58.933 3.206 1.00 19.39 ? 493 THR A C 1 ATOM 3905 O O . THR A 1 493 ? 21.190 59.900 3.793 1.00 19.09 ? 493 THR A O 1 ATOM 3906 C CB . THR A 1 493 ? 19.785 57.980 1.887 1.00 16.87 ? 493 THR A CB 1 ATOM 3907 O OG1 . THR A 1 493 ? 19.078 56.779 1.570 1.00 19.81 ? 493 THR A OG1 1 ATOM 3908 C CG2 . THR A 1 493 ? 20.404 58.551 0.624 1.00 14.41 ? 493 THR A CG2 1 ATOM 3909 N N . SER A 1 494 ? 22.944 58.927 2.765 1.00 18.90 ? 494 SER A N 1 ATOM 3910 C CA . SER A 1 494 ? 23.828 60.072 2.967 1.00 19.97 ? 494 SER A CA 1 ATOM 3911 C C . SER A 1 494 ? 24.322 60.675 1.658 1.00 21.25 ? 494 SER A C 1 ATOM 3912 O O . SER A 1 494 ? 24.535 59.959 0.676 1.00 21.71 ? 494 SER A O 1 ATOM 3913 C CB . SER A 1 494 ? 25.064 59.664 3.782 1.00 19.49 ? 494 SER A CB 1 ATOM 3914 O OG . SER A 1 494 ? 24.730 59.128 5.048 1.00 22.63 ? 494 SER A OG 1 ATOM 3915 N N . ARG A 1 495 ? 24.492 61.995 1.650 1.00 21.15 ? 495 ARG A N 1 ATOM 3916 C CA . ARG A 1 495 ? 25.039 62.699 0.493 1.00 20.60 ? 495 ARG A CA 1 ATOM 3917 C C . ARG A 1 495 ? 26.337 63.302 1.019 1.00 20.85 ? 495 ARG A C 1 ATOM 3918 O O . ARG A 1 495 ? 26.328 63.985 2.051 1.00 19.46 ? 495 ARG A O 1 ATOM 3919 C CB . ARG A 1 495 ? 24.117 63.827 0.006 1.00 19.90 ? 495 ARG A CB 1 ATOM 3920 C CG . ARG A 1 495 ? 22.840 63.367 -0.693 1.00 20.65 ? 495 ARG A CG 1 ATOM 3921 C CD . ARG A 1 495 ? 23.128 62.434 -1.862 1.00 20.54 ? 495 ARG A CD 1 ATOM 3922 N NE . ARG A 1 495 ? 23.904 63.044 -2.945 1.00 21.17 ? 495 ARG A NE 1 ATOM 3923 C CZ . ARG A 1 495 ? 23.435 63.947 -3.803 1.00 20.91 ? 495 ARG A CZ 1 ATOM 3924 N NH1 . ARG A 1 495 ? 22.183 64.372 -3.713 1.00 20.55 ? 495 ARG A NH1 1 ATOM 3925 N NH2 . ARG A 1 495 ? 24.213 64.402 -4.777 1.00 19.68 ? 495 ARG A NH2 1 ATOM 3926 N N . ILE A 1 496 ? 27.448 63.029 0.337 1.00 19.69 ? 496 ILE A N 1 ATOM 3927 C CA . ILE A 1 496 ? 28.744 63.556 0.756 1.00 20.32 ? 496 ILE A CA 1 ATOM 3928 C C . ILE A 1 496 ? 29.502 64.146 -0.427 1.00 20.84 ? 496 ILE A C 1 ATOM 3929 O O . ILE A 1 496 ? 29.377 63.677 -1.554 1.00 20.72 ? 496 ILE A O 1 ATOM 3930 C CB . ILE A 1 496 ? 29.633 62.464 1.422 1.00 19.79 ? 496 ILE A CB 1 ATOM 3931 C CG1 . ILE A 1 496 ? 29.987 61.360 0.412 1.00 20.99 ? 496 ILE A CG1 1 ATOM 3932 C CG2 . ILE A 1 496 ? 28.925 61.894 2.642 1.00 17.45 ? 496 ILE A CG2 1 ATOM 3933 C CD1 . ILE A 1 496 ? 28.812 60.483 -0.020 1.00 21.47 ? 496 ILE A CD1 1 ATOM 3934 N N . TYR A 1 497 ? 30.297 65.175 -0.159 1.00 21.77 ? 497 TYR A N 1 ATOM 3935 C CA . TYR A 1 497 ? 31.059 65.834 -1.208 1.00 23.72 ? 497 TYR A CA 1 ATOM 3936 C C . TYR A 1 497 ? 32.521 66.048 -0.815 1.00 24.33 ? 497 TYR A C 1 ATOM 3937 O O . TYR A 1 497 ? 32.979 67.185 -0.691 1.00 23.99 ? 497 TYR A O 1 ATOM 3938 C CB . TYR A 1 497 ? 30.418 67.186 -1.532 1.00 23.48 ? 497 TYR A CB 1 ATOM 3939 C CG . TYR A 1 497 ? 28.951 67.103 -1.897 1.00 24.32 ? 497 TYR A CG 1 ATOM 3940 C CD1 . TYR A 1 497 ? 28.542 67.022 -3.229 1.00 23.97 ? 497 TYR A CD1 1 ATOM 3941 C CD2 . TYR A 1 497 ? 27.970 67.111 -0.907 1.00 23.44 ? 497 TYR A CD2 1 ATOM 3942 C CE1 . TYR A 1 497 ? 27.184 66.958 -3.562 1.00 24.72 ? 497 TYR A CE1 1 ATOM 3943 C CE2 . TYR A 1 497 ? 26.620 67.044 -1.227 1.00 23.58 ? 497 TYR A CE2 1 ATOM 3944 C CZ . TYR A 1 497 ? 26.231 66.971 -2.553 1.00 24.40 ? 497 TYR A CZ 1 ATOM 3945 O OH . TYR A 1 497 ? 24.889 66.931 -2.859 1.00 24.80 ? 497 TYR A OH 1 ATOM 3946 N N . PRO A 1 498 ? 33.273 64.958 -0.597 1.00 24.74 ? 498 PRO A N 1 ATOM 3947 C CA . PRO A 1 498 ? 34.677 65.153 -0.227 1.00 26.02 ? 498 PRO A CA 1 ATOM 3948 C C . PRO A 1 498 ? 35.412 65.908 -1.331 1.00 28.20 ? 498 PRO A C 1 ATOM 3949 O O . PRO A 1 498 ? 35.031 65.843 -2.501 1.00 27.93 ? 498 PRO A O 1 ATOM 3950 C CB . PRO A 1 498 ? 35.189 63.726 -0.049 1.00 24.35 ? 498 PRO A CB 1 ATOM 3951 C CG . PRO A 1 498 ? 34.315 62.927 -0.977 1.00 24.15 ? 498 PRO A CG 1 ATOM 3952 C CD . PRO A 1 498 ? 32.955 63.527 -0.724 1.00 24.68 ? 498 PRO A CD 1 ATOM 3953 N N . LYS A 1 499 ? 36.462 66.629 -0.957 1.00 30.34 ? 499 LYS A N 1 ATOM 3954 C CA . LYS A 1 499 ? 37.227 67.394 -1.930 1.00 31.98 ? 499 LYS A CA 1 ATOM 3955 C C . LYS A 1 499 ? 38.225 66.548 -2.717 1.00 31.26 ? 499 LYS A C 1 ATOM 3956 O O . LYS A 1 499 ? 38.424 66.764 -3.913 1.00 31.80 ? 499 LYS A O 1 ATOM 3957 C CB . LYS A 1 499 ? 37.968 68.534 -1.227 1.00 35.68 ? 499 LYS A CB 1 ATOM 3958 C CG . LYS A 1 499 ? 38.768 69.408 -2.169 1.00 40.15 ? 499 LYS A CG 1 ATOM 3959 C CD . LYS A 1 499 ? 39.410 70.567 -1.432 1.00 45.35 ? 499 LYS A CD 1 ATOM 3960 C CE . LYS A 1 499 ? 40.064 71.535 -2.407 1.00 47.98 ? 499 LYS A CE 1 ATOM 3961 N NZ . LYS A 1 499 ? 40.604 72.733 -1.707 1.00 51.52 ? 499 LYS A NZ 1 ATOM 3962 N N . PHE A 1 500 ? 38.836 65.574 -2.052 1.00 29.64 ? 500 PHE A N 1 ATOM 3963 C CA . PHE A 1 500 ? 39.843 64.733 -2.694 1.00 30.57 ? 500 PHE A CA 1 ATOM 3964 C C . PHE A 1 500 ? 39.426 64.055 -4.001 1.00 30.56 ? 500 PHE A C 1 ATOM 3965 O O . PHE A 1 500 ? 40.274 63.785 -4.852 1.00 31.02 ? 500 PHE A O 1 ATOM 3966 C CB . PHE A 1 500 ? 40.345 63.672 -1.703 1.00 28.31 ? 500 PHE A CB 1 ATOM 3967 C CG . PHE A 1 500 ? 39.441 62.477 -1.576 1.00 28.44 ? 500 PHE A CG 1 ATOM 3968 C CD1 . PHE A 1 500 ? 39.479 61.455 -2.524 1.00 27.36 ? 500 PHE A CD1 1 ATOM 3969 C CD2 . PHE A 1 500 ? 38.542 62.377 -0.518 1.00 27.49 ? 500 PHE A CD2 1 ATOM 3970 C CE1 . PHE A 1 500 ? 38.636 60.350 -2.421 1.00 29.30 ? 500 PHE A CE1 1 ATOM 3971 C CE2 . PHE A 1 500 ? 37.692 61.277 -0.403 1.00 28.41 ? 500 PHE A CE2 1 ATOM 3972 C CZ . PHE A 1 500 ? 37.739 60.259 -1.358 1.00 29.61 ? 500 PHE A CZ 1 ATOM 3973 N N . VAL A 1 501 ? 38.136 63.776 -4.167 1.00 30.32 ? 501 VAL A N 1 ATOM 3974 C CA . VAL A 1 501 ? 37.671 63.097 -5.377 1.00 31.55 ? 501 VAL A CA 1 ATOM 3975 C C . VAL A 1 501 ? 37.953 63.843 -6.677 1.00 33.74 ? 501 VAL A C 1 ATOM 3976 O O . VAL A 1 501 ? 37.802 63.280 -7.761 1.00 33.49 ? 501 VAL A O 1 ATOM 3977 C CB . VAL A 1 501 ? 36.152 62.782 -5.321 1.00 29.27 ? 501 VAL A CB 1 ATOM 3978 C CG1 . VAL A 1 501 ? 35.853 61.872 -4.142 1.00 27.15 ? 501 VAL A CG1 1 ATOM 3979 C CG2 . VAL A 1 501 ? 35.348 64.072 -5.233 1.00 29.50 ? 501 VAL A CG2 1 ATOM 3980 N N . ASN A 1 502 ? 38.362 65.103 -6.582 1.00 35.81 ? 502 ASN A N 1 ATOM 3981 C CA . ASN A 1 502 ? 38.646 65.859 -7.793 1.00 37.77 ? 502 ASN A CA 1 ATOM 3982 C C . ASN A 1 502 ? 39.920 65.404 -8.493 1.00 39.27 ? 502 ASN A C 1 ATOM 3983 O O . ASN A 1 502 ? 40.045 65.552 -9.709 1.00 40.17 ? 502 ASN A O 1 ATOM 3984 C CB . ASN A 1 502 ? 38.721 67.355 -7.493 1.00 36.23 ? 502 ASN A CB 1 ATOM 3985 C CG . ASN A 1 502 ? 37.353 67.970 -7.285 1.00 37.71 ? 502 ASN A CG 1 ATOM 3986 O OD1 . ASN A 1 502 ? 36.979 68.330 -6.166 1.00 38.91 ? 502 ASN A OD1 1 ATOM 3987 N ND2 . ASN A 1 502 ? 36.587 68.083 -8.366 1.00 34.79 ? 502 ASN A ND2 1 ATOM 3988 N N . ASN A 1 503 ? 40.861 64.838 -7.747 1.00 40.58 ? 503 ASN A N 1 ATOM 3989 C CA . ASN A 1 503 ? 42.095 64.391 -8.374 1.00 43.34 ? 503 ASN A CA 1 ATOM 3990 C C . ASN A 1 503 ? 42.714 63.099 -7.848 1.00 43.34 ? 503 ASN A C 1 ATOM 3991 O O . ASN A 1 503 ? 43.802 62.721 -8.275 1.00 45.24 ? 503 ASN A O 1 ATOM 3992 C CB . ASN A 1 503 ? 43.130 65.516 -8.339 1.00 46.06 ? 503 ASN A CB 1 ATOM 3993 C CG . ASN A 1 503 ? 43.117 66.271 -7.033 1.00 50.01 ? 503 ASN A CG 1 ATOM 3994 O OD1 . ASN A 1 503 ? 43.280 65.685 -5.961 1.00 50.93 ? 503 ASN A OD1 1 ATOM 3995 N ND2 . ASN A 1 503 ? 42.920 67.587 -7.113 1.00 51.76 ? 503 ASN A ND2 1 ATOM 3996 N N . GLU A 1 504 ? 42.043 62.416 -6.927 1.00 42.16 ? 504 GLU A N 1 ATOM 3997 C CA . GLU A 1 504 ? 42.583 61.159 -6.428 1.00 41.01 ? 504 GLU A CA 1 ATOM 3998 C C . GLU A 1 504 ? 41.493 60.145 -6.111 1.00 39.81 ? 504 GLU A C 1 ATOM 3999 O O . GLU A 1 504 ? 40.336 60.504 -5.890 1.00 39.90 ? 504 GLU A O 1 ATOM 4000 C CB . GLU A 1 504 ? 43.483 61.398 -5.214 1.00 42.15 ? 504 GLU A CB 1 ATOM 4001 C CG . GLU A 1 504 ? 42.807 61.983 -4.005 1.00 46.37 ? 504 GLU A CG 1 ATOM 4002 C CD . GLU A 1 504 ? 43.814 62.474 -2.973 1.00 48.77 ? 504 GLU A CD 1 ATOM 4003 O OE1 . GLU A 1 504 ? 44.518 63.465 -3.262 1.00 49.73 ? 504 GLU A OE1 1 ATOM 4004 O OE2 . GLU A 1 504 ? 43.907 61.868 -1.882 1.00 48.31 ? 504 GLU A OE2 1 ATOM 4005 N N . GLU A 1 505 ? 41.869 58.872 -6.109 1.00 38.02 ? 505 GLU A N 1 ATOM 4006 C CA . GLU A 1 505 ? 40.926 57.797 -5.852 1.00 37.55 ? 505 GLU A CA 1 ATOM 4007 C C . GLU A 1 505 ? 40.478 57.679 -4.405 1.00 35.65 ? 505 GLU A C 1 ATOM 4008 O O . GLU A 1 505 ? 41.210 58.015 -3.472 1.00 33.21 ? 505 GLU A O 1 ATOM 4009 C CB . GLU A 1 505 ? 41.511 56.463 -6.306 1.00 41.52 ? 505 GLU A CB 1 ATOM 4010 C CG . GLU A 1 505 ? 41.776 56.388 -7.800 1.00 49.49 ? 505 GLU A CG 1 ATOM 4011 C CD . GLU A 1 505 ? 42.221 55.006 -8.240 1.00 54.40 ? 505 GLU A CD 1 ATOM 4012 O OE1 . GLU A 1 505 ? 43.198 54.482 -7.657 1.00 56.32 ? 505 GLU A OE1 1 ATOM 4013 O OE2 . GLU A 1 505 ? 41.594 54.446 -9.169 1.00 57.13 ? 505 GLU A OE2 1 ATOM 4014 N N . ALA A 1 506 ? 39.255 57.190 -4.238 1.00 33.14 ? 506 ALA A N 1 ATOM 4015 C CA . ALA A 1 506 ? 38.667 57.001 -2.924 1.00 31.08 ? 506 ALA A CA 1 ATOM 4016 C C . ALA A 1 506 ? 39.161 55.683 -2.352 1.00 29.51 ? 506 ALA A C 1 ATOM 4017 O O . ALA A 1 506 ? 39.658 54.825 -3.082 1.00 28.65 ? 506 ALA A O 1 ATOM 4018 C CB . ALA A 1 506 ? 37.147 56.984 -3.034 1.00 29.23 ? 506 ALA A CB 1 ATOM 4019 N N . HIS A 1 507 ? 39.030 55.528 -1.042 1.00 28.53 ? 507 HIS A N 1 ATOM 4020 C CA . HIS A 1 507 ? 39.449 54.306 -0.383 1.00 27.65 ? 507 HIS A CA 1 ATOM 4021 C C . HIS A 1 507 ? 38.310 53.771 0.462 1.00 26.70 ? 507 HIS A C 1 ATOM 4022 O O . HIS A 1 507 ? 37.336 54.478 0.732 1.00 26.23 ? 507 HIS A O 1 ATOM 4023 C CB . HIS A 1 507 ? 40.687 54.552 0.481 1.00 30.10 ? 507 HIS A CB 1 ATOM 4024 C CG . HIS A 1 507 ? 41.933 54.791 -0.313 1.00 32.41 ? 507 HIS A CG 1 ATOM 4025 N ND1 . HIS A 1 507 ? 42.156 55.954 -1.020 1.00 34.40 ? 507 HIS A ND1 1 ATOM 4026 C CD2 . HIS A 1 507 ? 43.003 53.996 -0.551 1.00 32.56 ? 507 HIS A CD2 1 ATOM 4027 C CE1 . HIS A 1 507 ? 43.309 55.865 -1.659 1.00 34.47 ? 507 HIS A CE1 1 ATOM 4028 N NE2 . HIS A 1 507 ? 43.842 54.686 -1.392 1.00 34.60 ? 507 HIS A NE2 1 ATOM 4029 N N . LEU A 1 508 ? 38.439 52.514 0.867 1.00 25.05 ? 508 LEU A N 1 ATOM 4030 C CA . LEU A 1 508 ? 37.431 51.843 1.666 1.00 24.24 ? 508 LEU A CA 1 ATOM 4031 C C . LEU A 1 508 ? 38.099 51.145 2.843 1.00 24.36 ? 508 LEU A C 1 ATOM 4032 O O . LEU A 1 508 ? 39.077 50.418 2.666 1.00 24.56 ? 508 LEU A O 1 ATOM 4033 C CB . LEU A 1 508 ? 36.700 50.823 0.795 1.00 25.02 ? 508 LEU A CB 1 ATOM 4034 C CG . LEU A 1 508 ? 35.645 49.922 1.439 1.00 24.02 ? 508 LEU A CG 1 ATOM 4035 C CD1 . LEU A 1 508 ? 34.525 50.760 2.035 1.00 21.91 ? 508 LEU A CD1 1 ATOM 4036 C CD2 . LEU A 1 508 ? 35.100 48.982 0.377 1.00 24.83 ? 508 LEU A CD2 1 ATOM 4037 N N . PHE A 1 509 ? 37.567 51.360 4.042 1.00 24.51 ? 509 PHE A N 1 ATOM 4038 C CA . PHE A 1 509 ? 38.129 50.756 5.248 1.00 23.91 ? 509 PHE A CA 1 ATOM 4039 C C . PHE A 1 509 ? 37.066 50.172 6.170 1.00 24.11 ? 509 PHE A C 1 ATOM 4040 O O . PHE A 1 509 ? 35.894 50.539 6.111 1.00 24.24 ? 509 PHE A O 1 ATOM 4041 C CB . PHE A 1 509 ? 38.886 51.796 6.079 1.00 22.83 ? 509 PHE A CB 1 ATOM 4042 C CG . PHE A 1 509 ? 39.979 52.512 5.346 1.00 22.74 ? 509 PHE A CG 1 ATOM 4043 C CD1 . PHE A 1 509 ? 41.304 52.110 5.487 1.00 21.73 ? 509 PHE A CD1 1 ATOM 4044 C CD2 . PHE A 1 509 ? 39.695 53.638 4.579 1.00 21.96 ? 509 PHE A CD2 1 ATOM 4045 C CE1 . PHE A 1 509 ? 42.334 52.823 4.882 1.00 21.67 ? 509 PHE A CE1 1 ATOM 4046 C CE2 . PHE A 1 509 ? 40.715 54.361 3.967 1.00 22.81 ? 509 PHE A CE2 1 ATOM 4047 C CZ . PHE A 1 509 ? 42.042 53.953 4.120 1.00 22.69 ? 509 PHE A CZ 1 ATOM 4048 N N . VAL A 1 510 ? 37.509 49.271 7.037 1.00 24.63 ? 510 VAL A N 1 ATOM 4049 C CA . VAL A 1 510 ? 36.663 48.662 8.054 1.00 24.79 ? 510 VAL A CA 1 ATOM 4050 C C . VAL A 1 510 ? 37.355 49.147 9.325 1.00 25.64 ? 510 VAL A C 1 ATOM 4051 O O . VAL A 1 510 ? 38.583 49.128 9.402 1.00 27.76 ? 510 VAL A O 1 ATOM 4052 C CB . VAL A 1 510 ? 36.712 47.125 8.000 1.00 25.28 ? 510 VAL A CB 1 ATOM 4053 C CG1 . VAL A 1 510 ? 35.848 46.544 9.103 1.00 25.49 ? 510 VAL A CG1 1 ATOM 4054 C CG2 . VAL A 1 510 ? 36.224 46.641 6.650 1.00 24.94 ? 510 VAL A CG2 1 ATOM 4055 N N . PHE A 1 511 ? 36.603 49.607 10.315 1.00 25.44 ? 511 PHE A N 1 ATOM 4056 C CA . PHE A 1 511 ? 37.261 50.096 11.520 1.00 24.96 ? 511 PHE A CA 1 ATOM 4057 C C . PHE A 1 511 ? 36.539 49.752 12.810 1.00 25.01 ? 511 PHE A C 1 ATOM 4058 O O . PHE A 1 511 ? 35.362 49.380 12.812 1.00 24.18 ? 511 PHE A O 1 ATOM 4059 C CB . PHE A 1 511 ? 37.450 51.619 11.434 1.00 25.24 ? 511 PHE A CB 1 ATOM 4060 C CG . PHE A 1 511 ? 36.222 52.407 11.803 1.00 24.46 ? 511 PHE A CG 1 ATOM 4061 C CD1 . PHE A 1 511 ? 36.136 53.049 13.034 1.00 25.26 ? 511 PHE A CD1 1 ATOM 4062 C CD2 . PHE A 1 511 ? 35.134 52.474 10.938 1.00 24.95 ? 511 PHE A CD2 1 ATOM 4063 C CE1 . PHE A 1 511 ? 34.979 53.744 13.402 1.00 26.01 ? 511 PHE A CE1 1 ATOM 4064 C CE2 . PHE A 1 511 ? 33.974 53.165 11.295 1.00 24.38 ? 511 PHE A CE2 1 ATOM 4065 C CZ . PHE A 1 511 ? 33.896 53.800 12.529 1.00 24.31 ? 511 PHE A CZ 1 ATOM 4066 N N . ASN A 1 512 ? 37.275 49.872 13.907 1.00 25.59 ? 512 ASN A N 1 ATOM 4067 C CA . ASN A 1 512 ? 36.745 49.626 15.239 1.00 26.35 ? 512 ASN A CA 1 ATOM 4068 C C . ASN A 1 512 ? 37.444 50.578 16.193 1.00 26.87 ? 512 ASN A C 1 ATOM 4069 O O . ASN A 1 512 ? 38.596 50.355 16.562 1.00 27.79 ? 512 ASN A O 1 ATOM 4070 C CB . ASN A 1 512 ? 36.999 48.184 15.673 1.00 25.16 ? 512 ASN A CB 1 ATOM 4071 C CG . ASN A 1 512 ? 36.657 47.953 17.133 1.00 26.02 ? 512 ASN A CG 1 ATOM 4072 O OD1 . ASN A 1 512 ? 35.858 48.685 17.714 1.00 25.85 ? 512 ASN A OD1 1 ATOM 4073 N ND2 . ASN A 1 512 ? 37.249 46.924 17.728 1.00 25.96 ? 512 ASN A ND2 1 ATOM 4074 N N . ASN A 1 513 ? 36.753 51.646 16.580 1.00 27.30 ? 513 ASN A N 1 ATOM 4075 C CA . ASN A 1 513 ? 37.335 52.622 17.490 1.00 27.32 ? 513 ASN A CA 1 ATOM 4076 C C . ASN A 1 513 ? 36.850 52.436 18.923 1.00 27.78 ? 513 ASN A C 1 ATOM 4077 O O . ASN A 1 513 ? 37.027 53.314 19.767 1.00 28.63 ? 513 ASN A O 1 ATOM 4078 C CB . ASN A 1 513 ? 37.042 54.050 17.015 1.00 26.58 ? 513 ASN A CB 1 ATOM 4079 C CG . ASN A 1 513 ? 38.283 54.923 17.025 1.00 28.25 ? 513 ASN A CG 1 ATOM 4080 O OD1 . ASN A 1 513 ? 39.357 54.459 17.413 1.00 29.19 ? 513 ASN A OD1 1 ATOM 4081 N ND2 . ASN A 1 513 ? 38.145 56.175 16.597 1.00 29.45 ? 513 ASN A ND2 1 ATOM 4082 N N . GLY A 1 514 ? 36.233 51.292 19.195 1.00 27.65 ? 514 GLY A N 1 ATOM 4083 C CA . GLY A 1 514 ? 35.776 51.016 20.544 1.00 28.44 ? 514 GLY A CA 1 ATOM 4084 C C . GLY A 1 514 ? 36.936 50.455 21.349 1.00 29.47 ? 514 GLY A C 1 ATOM 4085 O O . GLY A 1 514 ? 38.017 50.233 20.802 1.00 29.97 ? 514 GLY A O 1 ATOM 4086 N N . THR A 1 515 ? 36.736 50.233 22.645 1.00 30.58 ? 515 THR A N 1 ATOM 4087 C CA . THR A 1 515 ? 37.799 49.681 23.481 1.00 30.16 ? 515 THR A CA 1 ATOM 4088 C C . THR A 1 515 ? 37.663 48.163 23.546 1.00 30.99 ? 515 THR A C 1 ATOM 4089 O O . THR A 1 515 ? 38.558 47.465 24.022 1.00 31.03 ? 515 THR A O 1 ATOM 4090 C CB . THR A 1 515 ? 37.766 50.267 24.912 1.00 28.58 ? 515 THR A CB 1 ATOM 4091 O OG1 . THR A 1 515 ? 36.479 50.038 25.499 1.00 29.42 ? 515 THR A OG1 1 ATOM 4092 C CG2 . THR A 1 515 ? 38.054 51.761 24.877 1.00 25.46 ? 515 THR A CG2 1 ATOM 4093 N N . GLN A 1 516 ? 36.533 47.660 23.062 1.00 31.59 ? 516 GLN A N 1 ATOM 4094 C CA . GLN A 1 516 ? 36.284 46.226 23.029 1.00 34.18 ? 516 GLN A CA 1 ATOM 4095 C C . GLN A 1 516 ? 36.596 45.710 21.634 1.00 35.56 ? 516 GLN A C 1 ATOM 4096 O O . GLN A 1 516 ? 36.474 46.433 20.641 1.00 35.29 ? 516 GLN A O 1 ATOM 4097 C CB . GLN A 1 516 ? 34.823 45.912 23.363 1.00 35.67 ? 516 GLN A CB 1 ATOM 4098 C CG . GLN A 1 516 ? 34.462 46.094 24.820 1.00 40.30 ? 516 GLN A CG 1 ATOM 4099 C CD . GLN A 1 516 ? 35.114 45.058 25.708 1.00 42.40 ? 516 GLN A CD 1 ATOM 4100 O OE1 . GLN A 1 516 ? 34.808 43.864 25.619 1.00 43.88 ? 516 GLN A OE1 1 ATOM 4101 N NE2 . GLN A 1 516 ? 36.023 45.504 26.571 1.00 41.80 ? 516 GLN A NE2 1 ATOM 4102 N N . ASN A 1 517 ? 36.996 44.449 21.573 1.00 36.10 ? 517 ASN A N 1 ATOM 4103 C CA . ASN A 1 517 ? 37.337 43.795 20.324 1.00 36.27 ? 517 ASN A CA 1 ATOM 4104 C C . ASN A 1 517 ? 36.048 43.390 19.618 1.00 35.00 ? 517 ASN A C 1 ATOM 4105 O O . ASN A 1 517 ? 35.046 43.095 20.270 1.00 35.33 ? 517 ASN A O 1 ATOM 4106 C CB . ASN A 1 517 ? 38.174 42.548 20.633 1.00 39.62 ? 517 ASN A CB 1 ATOM 4107 C CG . ASN A 1 517 ? 39.261 42.296 19.610 1.00 44.67 ? 517 ASN A CG 1 ATOM 4108 O OD1 . ASN A 1 517 ? 38.995 41.840 18.489 1.00 48.17 ? 517 ASN A OD1 1 ATOM 4109 N ND2 . ASN A 1 517 ? 40.503 42.594 19.990 1.00 44.18 ? 517 ASN A ND2 1 ATOM 4110 N N . VAL A 1 518 ? 36.068 43.406 18.289 1.00 33.65 ? 518 VAL A N 1 ATOM 4111 C CA . VAL A 1 518 ? 34.917 42.981 17.492 1.00 33.29 ? 518 VAL A CA 1 ATOM 4112 C C . VAL A 1 518 ? 35.458 42.155 16.336 1.00 32.60 ? 518 VAL A C 1 ATOM 4113 O O . VAL A 1 518 ? 36.584 42.370 15.885 1.00 33.23 ? 518 VAL A O 1 ATOM 4114 C CB . VAL A 1 518 ? 34.092 44.168 16.914 1.00 32.82 ? 518 VAL A CB 1 ATOM 4115 C CG1 . VAL A 1 518 ? 33.460 44.959 18.043 1.00 34.75 ? 518 VAL A CG1 1 ATOM 4116 C CG2 . VAL A 1 518 ? 34.972 45.057 16.048 1.00 32.57 ? 518 VAL A CG2 1 ATOM 4117 N N . LYS A 1 519 ? 34.662 41.207 15.859 1.00 31.81 ? 519 LYS A N 1 ATOM 4118 C CA . LYS A 1 519 ? 35.096 40.350 14.772 1.00 31.54 ? 519 LYS A CA 1 ATOM 4119 C C . LYS A 1 519 ? 34.246 40.455 13.515 1.00 30.68 ? 519 LYS A C 1 ATOM 4120 O O . LYS A 1 519 ? 33.017 40.530 13.577 1.00 31.43 ? 519 LYS A O 1 ATOM 4121 C CB . LYS A 1 519 ? 35.127 38.888 15.245 1.00 33.62 ? 519 LYS A CB 1 ATOM 4122 C CG . LYS A 1 519 ? 35.286 37.868 14.113 1.00 38.85 ? 519 LYS A CG 1 ATOM 4123 C CD . LYS A 1 519 ? 36.433 36.890 14.351 1.00 41.44 ? 519 LYS A CD 1 ATOM 4124 C CE . LYS A 1 519 ? 36.090 35.831 15.384 1.00 43.63 ? 519 LYS A CE 1 ATOM 4125 N NZ . LYS A 1 519 ? 37.191 34.826 15.528 1.00 43.94 ? 519 LYS A NZ 1 ATOM 4126 N N . ILE A 1 520 ? 34.916 40.471 12.370 1.00 29.95 ? 520 ILE A N 1 ATOM 4127 C CA . ILE A 1 520 ? 34.234 40.507 11.087 1.00 28.74 ? 520 ILE A CA 1 ATOM 4128 C C . ILE A 1 520 ? 34.048 39.038 10.744 1.00 28.62 ? 520 ILE A C 1 ATOM 4129 O O . ILE A 1 520 ? 35.016 38.356 10.427 1.00 30.07 ? 520 ILE A O 1 ATOM 4130 C CB . ILE A 1 520 ? 35.114 41.126 9.988 1.00 29.42 ? 520 ILE A CB 1 ATOM 4131 C CG1 . ILE A 1 520 ? 35.472 42.567 10.347 1.00 30.26 ? 520 ILE A CG1 1 ATOM 4132 C CG2 . ILE A 1 520 ? 34.390 41.060 8.648 1.00 28.05 ? 520 ILE A CG2 1 ATOM 4133 C CD1 . ILE A 1 520 ? 36.466 43.194 9.399 1.00 28.93 ? 520 ILE A CD1 1 ATOM 4134 N N . SER A 1 521 ? 32.828 38.530 10.827 1.00 29.06 ? 521 SER A N 1 ATOM 4135 C CA . SER A 1 521 ? 32.627 37.130 10.490 1.00 31.10 ? 521 SER A CA 1 ATOM 4136 C C . SER A 1 521 ? 32.623 36.977 8.967 1.00 32.65 ? 521 SER A C 1 ATOM 4137 O O . SER A 1 521 ? 33.220 36.050 8.421 1.00 33.35 ? 521 SER A O 1 ATOM 4138 C CB . SER A 1 521 ? 31.312 36.614 11.078 1.00 29.17 ? 521 SER A CB 1 ATOM 4139 O OG . SER A 1 521 ? 30.204 37.275 10.505 1.00 33.27 ? 521 SER A OG 1 ATOM 4140 N N . GLU A 1 522 ? 31.962 37.905 8.285 1.00 33.71 ? 522 GLU A N 1 ATOM 4141 C CA . GLU A 1 522 ? 31.876 37.868 6.833 1.00 34.58 ? 522 GLU A CA 1 ATOM 4142 C C . GLU A 1 522 ? 31.813 39.276 6.269 1.00 32.48 ? 522 GLU A C 1 ATOM 4143 O O . GLU A 1 522 ? 31.181 40.159 6.846 1.00 29.75 ? 522 GLU A O 1 ATOM 4144 C CB . GLU A 1 522 ? 30.626 37.096 6.404 1.00 39.07 ? 522 GLU A CB 1 ATOM 4145 C CG . GLU A 1 522 ? 30.898 35.760 5.726 1.00 47.64 ? 522 GLU A CG 1 ATOM 4146 C CD . GLU A 1 522 ? 30.924 35.867 4.209 1.00 51.18 ? 522 GLU A CD 1 ATOM 4147 O OE1 . GLU A 1 522 ? 31.747 36.641 3.673 1.00 54.59 ? 522 GLU A OE1 1 ATOM 4148 O OE2 . GLU A 1 522 ? 30.119 35.174 3.551 1.00 52.07 ? 522 GLU A OE2 1 ATOM 4149 N N . MET A 1 523 ? 32.477 39.478 5.138 1.00 31.32 ? 523 MET A N 1 ATOM 4150 C CA . MET A 1 523 ? 32.488 40.772 4.475 1.00 30.59 ? 523 MET A CA 1 ATOM 4151 C C . MET A 1 523 ? 32.622 40.560 2.967 1.00 29.43 ? 523 MET A C 1 ATOM 4152 O O . MET A 1 523 ? 33.578 39.937 2.505 1.00 28.79 ? 523 MET A O 1 ATOM 4153 C CB . MET A 1 523 ? 33.647 41.618 4.996 1.00 31.70 ? 523 MET A CB 1 ATOM 4154 C CG . MET A 1 523 ? 33.467 43.106 4.775 1.00 36.85 ? 523 MET A CG 1 ATOM 4155 S SD . MET A 1 523 ? 34.503 43.792 3.471 1.00 45.57 ? 523 MET A SD 1 ATOM 4156 C CE . MET A 1 523 ? 33.568 43.424 2.070 1.00 37.37 ? 523 MET A CE 1 ATOM 4157 N N . SER A 1 524 ? 31.648 41.060 2.210 1.00 27.25 ? 524 SER A N 1 ATOM 4158 C CA . SER A 1 524 ? 31.655 40.940 0.755 1.00 25.80 ? 524 SER A CA 1 ATOM 4159 C C . SER A 1 524 ? 31.607 42.319 0.126 1.00 25.13 ? 524 SER A C 1 ATOM 4160 O O . SER A 1 524 ? 30.727 43.122 0.442 1.00 23.52 ? 524 SER A O 1 ATOM 4161 C CB . SER A 1 524 ? 30.449 40.139 0.263 1.00 26.44 ? 524 SER A CB 1 ATOM 4162 O OG . SER A 1 524 ? 30.449 38.829 0.798 1.00 31.45 ? 524 SER A OG 1 ATOM 4163 N N . ALA A 1 525 ? 32.563 42.591 -0.756 1.00 24.25 ? 525 ALA A N 1 ATOM 4164 C CA . ALA A 1 525 ? 32.630 43.872 -1.446 1.00 23.73 ? 525 ALA A CA 1 ATOM 4165 C C . ALA A 1 525 ? 32.699 43.622 -2.949 1.00 25.01 ? 525 ALA A C 1 ATOM 4166 O O . ALA A 1 525 ? 33.452 42.765 -3.414 1.00 26.01 ? 525 ALA A O 1 ATOM 4167 C CB . ALA A 1 525 ? 33.850 44.655 -0.984 1.00 20.24 ? 525 ALA A CB 1 ATOM 4168 N N . TRP A 1 526 ? 31.900 44.365 -3.705 1.00 25.89 ? 526 TRP A N 1 ATOM 4169 C CA . TRP A 1 526 ? 31.874 44.225 -5.159 1.00 25.88 ? 526 TRP A CA 1 ATOM 4170 C C . TRP A 1 526 ? 32.041 45.571 -5.839 1.00 25.78 ? 526 TRP A C 1 ATOM 4171 O O . TRP A 1 526 ? 31.437 46.560 -5.419 1.00 25.91 ? 526 TRP A O 1 ATOM 4172 C CB . TRP A 1 526 ? 30.533 43.662 -5.632 1.00 25.93 ? 526 TRP A CB 1 ATOM 4173 C CG . TRP A 1 526 ? 30.316 42.209 -5.433 1.00 28.19 ? 526 TRP A CG 1 ATOM 4174 C CD1 . TRP A 1 526 ? 30.742 41.194 -6.243 1.00 28.45 ? 526 TRP A CD1 1 ATOM 4175 C CD2 . TRP A 1 526 ? 29.572 41.597 -4.375 1.00 28.42 ? 526 TRP A CD2 1 ATOM 4176 N NE1 . TRP A 1 526 ? 30.303 39.985 -5.754 1.00 30.23 ? 526 TRP A NE1 1 ATOM 4177 C CE2 . TRP A 1 526 ? 29.582 40.205 -4.608 1.00 29.43 ? 526 TRP A CE2 1 ATOM 4178 C CE3 . TRP A 1 526 ? 28.895 42.091 -3.251 1.00 31.79 ? 526 TRP A CE3 1 ATOM 4179 C CZ2 . TRP A 1 526 ? 28.940 39.297 -3.755 1.00 31.33 ? 526 TRP A CZ2 1 ATOM 4180 C CZ3 . TRP A 1 526 ? 28.254 41.187 -2.400 1.00 33.26 ? 526 TRP A CZ3 1 ATOM 4181 C CH2 . TRP A 1 526 ? 28.283 39.805 -2.660 1.00 31.92 ? 526 TRP A CH2 1 ATOM 4182 N N . SER A 1 527 ? 32.863 45.610 -6.881 1.00 25.10 ? 527 SER A N 1 ATOM 4183 C CA . SER A 1 527 ? 33.012 46.830 -7.657 1.00 25.26 ? 527 SER A CA 1 ATOM 4184 C C . SER A 1 527 ? 31.723 46.814 -8.474 1.00 24.78 ? 527 SER A C 1 ATOM 4185 O O . SER A 1 527 ? 31.277 45.748 -8.900 1.00 24.88 ? 527 SER A O 1 ATOM 4186 C CB . SER A 1 527 ? 34.219 46.745 -8.594 1.00 25.04 ? 527 SER A CB 1 ATOM 4187 O OG . SER A 1 527 ? 35.435 46.849 -7.877 1.00 27.45 ? 527 SER A OG 1 ATOM 4188 N N . MET A 1 528 ? 31.109 47.972 -8.669 1.00 25.07 ? 528 MET A N 1 ATOM 4189 C CA . MET A 1 528 ? 29.864 48.046 -9.428 1.00 25.96 ? 528 MET A CA 1 ATOM 4190 C C . MET A 1 528 ? 30.101 48.777 -10.739 1.00 26.76 ? 528 MET A C 1 ATOM 4191 O O . MET A 1 528 ? 30.631 49.887 -10.743 1.00 28.13 ? 528 MET A O 1 ATOM 4192 C CB . MET A 1 528 ? 28.803 48.803 -8.625 1.00 26.50 ? 528 MET A CB 1 ATOM 4193 C CG . MET A 1 528 ? 28.450 48.181 -7.288 1.00 26.14 ? 528 MET A CG 1 ATOM 4194 S SD . MET A 1 528 ? 27.572 46.636 -7.483 1.00 29.73 ? 528 MET A SD 1 ATOM 4195 C CE . MET A 1 528 ? 25.887 47.175 -7.405 1.00 27.95 ? 528 MET A CE 1 ATOM 4196 N N . LYS A 1 529 ? 29.722 48.168 -11.855 1.00 27.05 ? 529 LYS A N 1 ATOM 4197 C CA . LYS A 1 529 ? 29.909 48.837 -13.132 1.00 28.65 ? 529 LYS A CA 1 ATOM 4198 C C . LYS A 1 529 ? 28.795 49.863 -13.298 1.00 28.77 ? 529 LYS A C 1 ATOM 4199 O O . LYS A 1 529 ? 27.787 49.814 -12.595 1.00 28.52 ? 529 LYS A O 1 ATOM 4200 C CB . LYS A 1 529 ? 29.875 47.838 -14.290 1.00 30.82 ? 529 LYS A CB 1 ATOM 4201 C CG . LYS A 1 529 ? 28.525 47.210 -14.553 1.00 36.00 ? 529 LYS A CG 1 ATOM 4202 C CD . LYS A 1 529 ? 28.602 46.278 -15.753 1.00 40.22 ? 529 LYS A CD 1 ATOM 4203 C CE . LYS A 1 529 ? 27.293 45.529 -15.971 1.00 45.28 ? 529 LYS A CE 1 ATOM 4204 N NZ . LYS A 1 529 ? 27.380 44.574 -17.121 1.00 48.36 ? 529 LYS A NZ 1 ATOM 4205 N N . ASN A 1 530 ? 28.988 50.794 -14.223 1.00 28.24 ? 530 ASN A N 1 ATOM 4206 C CA . ASN A 1 530 ? 28.005 51.833 -14.484 1.00 27.80 ? 530 ASN A CA 1 ATOM 4207 C C . ASN A 1 530 ? 26.704 51.263 -15.020 1.00 27.87 ? 530 ASN A C 1 ATOM 4208 O O . ASN A 1 530 ? 26.697 50.246 -15.716 1.00 28.27 ? 530 ASN A O 1 ATOM 4209 C CB . ASN A 1 530 ? 28.540 52.814 -15.527 1.00 28.03 ? 530 ASN A CB 1 ATOM 4210 C CG . ASN A 1 530 ? 29.722 53.614 -15.035 1.00 27.77 ? 530 ASN A CG 1 ATOM 4211 O OD1 . ASN A 1 530 ? 30.531 54.071 -15.831 1.00 31.97 ? 530 ASN A OD1 1 ATOM 4212 N ND2 . ASN A 1 530 ? 29.821 53.803 -13.729 1.00 28.85 ? 530 ASN A ND2 1 ATOM 4213 N N . ALA A 1 531 ? 25.600 51.917 -14.681 1.00 28.20 ? 531 ALA A N 1 ATOM 4214 C CA . ALA A 1 531 ? 24.300 51.525 -15.208 1.00 27.52 ? 531 ALA A CA 1 ATOM 4215 C C . ALA A 1 531 ? 24.282 52.263 -16.556 1.00 27.87 ? 531 ALA A C 1 ATOM 4216 O O . ALA A 1 531 ? 25.005 53.251 -16.727 1.00 25.95 ? 531 ALA A O 1 ATOM 4217 C CB . ALA A 1 531 ? 23.183 52.038 -14.307 1.00 25.16 ? 531 ALA A CB 1 ATOM 4218 N N . LYS A 1 532 ? 23.493 51.795 -17.516 1.00 27.93 ? 532 LYS A N 1 ATOM 4219 C CA . LYS A 1 532 ? 23.454 52.476 -18.805 1.00 29.92 ? 532 LYS A CA 1 ATOM 4220 C C . LYS A 1 532 ? 22.339 53.506 -18.856 1.00 28.68 ? 532 LYS A C 1 ATOM 4221 O O . LYS A 1 532 ? 21.222 53.246 -18.423 1.00 29.84 ? 532 LYS A O 1 ATOM 4222 C CB . LYS A 1 532 ? 23.265 51.477 -19.949 1.00 32.40 ? 532 LYS A CB 1 ATOM 4223 C CG . LYS A 1 532 ? 24.303 50.379 -19.994 1.00 38.54 ? 532 LYS A CG 1 ATOM 4224 C CD . LYS A 1 532 ? 24.090 49.470 -21.198 1.00 44.67 ? 532 LYS A CD 1 ATOM 4225 C CE . LYS A 1 532 ? 24.944 48.209 -21.102 1.00 47.51 ? 532 LYS A CE 1 ATOM 4226 N NZ . LYS A 1 532 ? 26.379 48.518 -20.819 1.00 49.48 ? 532 LYS A NZ 1 ATOM 4227 N N . PHE A 1 533 ? 22.659 54.682 -19.382 1.00 28.76 ? 533 PHE A N 1 ATOM 4228 C CA . PHE A 1 533 ? 21.693 55.761 -19.526 1.00 28.81 ? 533 PHE A CA 1 ATOM 4229 C C . PHE A 1 533 ? 21.750 56.248 -20.962 1.00 31.31 ? 533 PHE A C 1 ATOM 4230 O O . PHE A 1 533 ? 22.673 56.964 -21.351 1.00 32.48 ? 533 PHE A O 1 ATOM 4231 C CB . PHE A 1 533 ? 22.024 56.902 -18.569 1.00 26.25 ? 533 PHE A CB 1 ATOM 4232 C CG . PHE A 1 533 ? 21.698 56.598 -17.144 1.00 27.24 ? 533 PHE A CG 1 ATOM 4233 C CD1 . PHE A 1 533 ? 20.402 56.764 -16.666 1.00 25.12 ? 533 PHE A CD1 1 ATOM 4234 C CD2 . PHE A 1 533 ? 22.674 56.104 -16.284 1.00 26.10 ? 533 PHE A CD2 1 ATOM 4235 C CE1 . PHE A 1 533 ? 20.081 56.442 -15.353 1.00 24.76 ? 533 PHE A CE1 1 ATOM 4236 C CE2 . PHE A 1 533 ? 22.362 55.778 -14.966 1.00 26.52 ? 533 PHE A CE2 1 ATOM 4237 C CZ . PHE A 1 533 ? 21.059 55.948 -14.500 1.00 25.50 ? 533 PHE A CZ 1 ATOM 4238 N N . VAL A 1 534 ? 20.763 55.841 -21.752 1.00 32.90 ? 534 VAL A N 1 ATOM 4239 C CA . VAL A 1 534 ? 20.696 56.226 -23.152 1.00 32.91 ? 534 VAL A CA 1 ATOM 4240 C C . VAL A 1 534 ? 19.687 57.346 -23.363 1.00 34.53 ? 534 VAL A C 1 ATOM 4241 O O . VAL A 1 534 ? 18.569 57.296 -22.849 1.00 34.04 ? 534 VAL A O 1 ATOM 4242 C CB . VAL A 1 534 ? 20.289 55.025 -24.030 1.00 33.83 ? 534 VAL A CB 1 ATOM 4243 C CG1 . VAL A 1 534 ? 20.132 55.462 -25.481 1.00 33.50 ? 534 VAL A CG1 1 ATOM 4244 C CG2 . VAL A 1 534 ? 21.333 53.926 -23.915 1.00 33.01 ? 534 VAL A CG2 1 ATOM 4245 N N . VAL A 1 535 ? 20.087 58.361 -24.117 1.00 35.70 ? 535 VAL A N 1 ATOM 4246 C CA . VAL A 1 535 ? 19.194 59.470 -24.402 1.00 37.44 ? 535 VAL A CA 1 ATOM 4247 C C . VAL A 1 535 ? 18.471 59.228 -25.722 1.00 39.58 ? 535 VAL A C 1 ATOM 4248 O O . VAL A 1 535 ? 19.090 58.880 -26.729 1.00 41.51 ? 535 VAL A O 1 ATOM 4249 C CB . VAL A 1 535 ? 19.957 60.802 -24.494 1.00 36.08 ? 535 VAL A CB 1 ATOM 4250 C CG1 . VAL A 1 535 ? 19.008 61.916 -24.917 1.00 34.31 ? 535 VAL A CG1 1 ATOM 4251 C CG2 . VAL A 1 535 ? 20.577 61.131 -23.149 1.00 34.85 ? 535 VAL A CG2 1 ATOM 4252 N N . ASP A 1 536 ? 17.156 59.403 -25.704 1.00 40.21 ? 536 ASP A N 1 ATOM 4253 C CA . ASP A 1 536 ? 16.334 59.228 -26.895 1.00 42.03 ? 536 ASP A CA 1 ATOM 4254 C C . ASP A 1 536 ? 15.266 60.320 -26.875 1.00 43.19 ? 536 ASP A C 1 ATOM 4255 O O . ASP A 1 536 ? 14.091 60.055 -26.615 1.00 42.44 ? 536 ASP A O 1 ATOM 4256 C CB . ASP A 1 536 ? 15.698 57.839 -26.884 1.00 42.20 ? 536 ASP A CB 1 ATOM 4257 C CG . ASP A 1 536 ? 14.843 57.582 -28.102 1.00 45.80 ? 536 ASP A CG 1 ATOM 4258 O OD1 . ASP A 1 536 ? 15.165 58.129 -29.178 1.00 48.65 ? 536 ASP A OD1 1 ATOM 4259 O OD2 . ASP A 1 536 ? 13.857 56.823 -27.990 1.00 46.88 ? 536 ASP A OD2 1 ATOM 4260 N N . GLN A 1 537 ? 15.694 61.549 -27.154 1.00 44.95 ? 537 GLN A N 1 ATOM 4261 C CA . GLN A 1 537 ? 14.813 62.714 -27.131 1.00 48.08 ? 537 GLN A CA 1 ATOM 4262 C C . GLN A 1 537 ? 14.636 63.470 -28.455 1.00 50.89 ? 537 GLN A C 1 ATOM 4263 O O . GLN A 1 537 ? 14.959 62.956 -29.528 1.00 51.40 ? 537 GLN A O 1 ATOM 4264 C CB . GLN A 1 537 ? 15.307 63.676 -26.050 1.00 44.76 ? 537 GLN A CB 1 ATOM 4265 C CG . GLN A 1 537 ? 15.155 63.123 -24.644 1.00 43.24 ? 537 GLN A CG 1 ATOM 4266 C CD . GLN A 1 537 ? 15.913 63.927 -23.606 1.00 41.40 ? 537 GLN A CD 1 ATOM 4267 O OE1 . GLN A 1 537 ? 15.627 63.841 -22.413 1.00 42.03 ? 537 GLN A OE1 1 ATOM 4268 N NE2 . GLN A 1 537 ? 16.893 64.701 -24.053 1.00 39.56 ? 537 GLN A NE2 1 ATOM 4269 N N . SER A 1 538 ? 14.115 64.696 -28.353 1.00 54.52 ? 538 SER A N 1 ATOM 4270 C CA . SER A 1 538 ? 13.854 65.570 -29.502 1.00 56.31 ? 538 SER A CA 1 ATOM 4271 C C . SER A 1 538 ? 12.836 64.954 -30.450 1.00 56.80 ? 538 SER A C 1 ATOM 4272 O O . SER A 1 538 ? 11.773 64.505 -30.022 1.00 57.38 ? 538 SER A O 1 ATOM 4273 C CB . SER A 1 538 ? 15.148 65.872 -30.269 1.00 57.79 ? 538 SER A CB 1 ATOM 4274 O OG . SER A 1 538 ? 16.008 66.709 -29.514 1.00 59.84 ? 538 SER A OG 1 HETATM 4275 C C1 . NAG B 2 . ? 39.283 57.078 16.589 1.00 31.79 ? 650 NAG A C1 1 HETATM 4276 C C2 . NAG B 2 . ? 39.234 57.965 15.334 1.00 32.32 ? 650 NAG A C2 1 HETATM 4277 C C3 . NAG B 2 . ? 40.360 59.011 15.353 1.00 33.57 ? 650 NAG A C3 1 HETATM 4278 C C4 . NAG B 2 . ? 40.314 59.808 16.672 1.00 36.23 ? 650 NAG A C4 1 HETATM 4279 C C5 . NAG B 2 . ? 40.396 58.805 17.827 1.00 34.14 ? 650 NAG A C5 1 HETATM 4280 C C6 . NAG B 2 . ? 40.374 59.458 19.194 1.00 31.28 ? 650 NAG A C6 1 HETATM 4281 C C7 . NAG B 2 . ? 38.418 57.159 13.207 1.00 32.02 ? 650 NAG A C7 1 HETATM 4282 C C8 . NAG B 2 . ? 38.558 56.152 12.076 1.00 30.16 ? 650 NAG A C8 1 HETATM 4283 N N2 . NAG B 2 . ? 39.356 57.136 14.152 1.00 32.82 ? 650 NAG A N2 1 HETATM 4284 O O3 . NAG B 2 . ? 40.210 59.880 14.242 1.00 31.61 ? 650 NAG A O3 1 HETATM 4285 O O4 . NAG B 2 . ? 41.416 60.747 16.780 1.00 45.10 ? 650 NAG A O4 1 HETATM 4286 O O5 . NAG B 2 . ? 39.282 57.887 17.773 1.00 32.98 ? 650 NAG A O5 1 HETATM 4287 O O6 . NAG B 2 . ? 39.308 60.388 19.299 1.00 29.03 ? 650 NAG A O6 1 HETATM 4288 O O7 . NAG B 2 . ? 37.470 57.945 13.216 1.00 31.22 ? 650 NAG A O7 1 HETATM 4289 C C1 . NAG C 2 . ? 41.653 61.691 15.783 1.00 55.85 ? 660 NAG A C1 1 HETATM 4290 C C2 . NAG C 2 . ? 40.567 62.771 15.736 1.00 60.78 ? 660 NAG A C2 1 HETATM 4291 C C3 . NAG C 2 . ? 40.594 63.622 17.002 1.00 64.96 ? 660 NAG A C3 1 HETATM 4292 C C4 . NAG C 2 . ? 41.989 64.202 17.251 1.00 65.28 ? 660 NAG A C4 1 HETATM 4293 C C5 . NAG C 2 . ? 43.083 63.118 17.185 1.00 60.83 ? 660 NAG A C5 1 HETATM 4294 C C6 . NAG C 2 . ? 43.133 62.207 18.400 1.00 57.13 ? 660 NAG A C6 1 HETATM 4295 C C7 . NAG C 2 . ? 39.791 64.335 14.077 1.00 64.40 ? 660 NAG A C7 1 HETATM 4296 C C8 . NAG C 2 . ? 39.907 64.753 12.618 1.00 64.27 ? 660 NAG A C8 1 HETATM 4297 N N2 . NAG C 2 . ? 40.791 63.626 14.587 1.00 63.48 ? 660 NAG A N2 1 HETATM 4298 O O3 . NAG C 2 . ? 40.206 62.832 18.116 1.00 69.86 ? 660 NAG A O3 1 HETATM 4299 O O4 . NAG C 2 . ? 42.279 65.286 16.335 1.00 70.63 ? 660 NAG A O4 1 HETATM 4300 O O5 . NAG C 2 . ? 42.957 62.282 15.992 1.00 60.54 ? 660 NAG A O5 1 HETATM 4301 O O6 . NAG C 2 . ? 44.043 61.136 18.202 1.00 51.03 ? 660 NAG A O6 1 HETATM 4302 O O7 . NAG C 2 . ? 38.799 64.652 14.732 1.00 65.30 ? 660 NAG A O7 1 HETATM 4303 C C1 . MAN D 3 . ? 42.416 66.530 16.947 1.00 76.15 ? 670 MAN A C1 1 HETATM 4304 C C2 . MAN D 3 . ? 41.083 67.308 16.968 1.00 77.17 ? 670 MAN A C2 1 HETATM 4305 C C3 . MAN D 3 . ? 40.769 67.964 15.620 1.00 78.15 ? 670 MAN A C3 1 HETATM 4306 C C4 . MAN D 3 . ? 41.971 68.772 15.154 1.00 79.10 ? 670 MAN A C4 1 HETATM 4307 C C5 . MAN D 3 . ? 43.170 67.834 15.036 1.00 79.13 ? 670 MAN A C5 1 HETATM 4308 C C6 . MAN D 3 . ? 44.413 68.554 14.539 1.00 80.01 ? 670 MAN A C6 1 HETATM 4309 O O2 . MAN D 3 . ? 41.137 68.308 17.974 1.00 78.10 ? 670 MAN A O2 1 HETATM 4310 O O3 . MAN D 3 . ? 39.644 68.822 15.754 1.00 78.07 ? 670 MAN A O3 1 HETATM 4311 O O4 . MAN D 3 . ? 41.692 69.382 13.901 1.00 79.45 ? 670 MAN A O4 1 HETATM 4312 O O5 . MAN D 3 . ? 43.492 67.279 16.335 1.00 78.26 ? 670 MAN A O5 1 HETATM 4313 O O6 . MAN D 3 . ? 44.909 67.966 13.344 1.00 80.22 ? 670 MAN A O6 1 HETATM 4314 C C1 . NAG E 2 . ? 2.319 55.168 -31.741 1.00 32.09 ? 680 NAG A C1 1 HETATM 4315 C C2 . NAG E 2 . ? 2.864 56.124 -32.816 1.00 33.94 ? 680 NAG A C2 1 HETATM 4316 C C3 . NAG E 2 . ? 3.493 55.334 -33.974 1.00 35.32 ? 680 NAG A C3 1 HETATM 4317 C C4 . NAG E 2 . ? 4.505 54.306 -33.451 1.00 36.51 ? 680 NAG A C4 1 HETATM 4318 C C5 . NAG E 2 . ? 3.850 53.439 -32.375 1.00 35.36 ? 680 NAG A C5 1 HETATM 4319 C C6 . NAG E 2 . ? 4.818 52.450 -31.751 1.00 35.96 ? 680 NAG A C6 1 HETATM 4320 C C7 . NAG E 2 . ? 1.912 58.286 -33.340 1.00 31.23 ? 680 NAG A C7 1 HETATM 4321 C C8 . NAG E 2 . ? 0.657 59.094 -33.640 1.00 31.73 ? 680 NAG A C8 1 HETATM 4322 N N2 . NAG E 2 . ? 1.791 56.961 -33.325 1.00 31.54 ? 680 NAG A N2 1 HETATM 4323 O O3 . NAG E 2 . ? 4.141 56.236 -34.861 1.00 35.33 ? 680 NAG A O3 1 HETATM 4324 O O4 . NAG E 2 . ? 4.957 53.467 -34.533 1.00 40.96 ? 680 NAG A O4 1 HETATM 4325 O O5 . NAG E 2 . ? 3.349 54.271 -31.309 1.00 33.39 ? 680 NAG A O5 1 HETATM 4326 O O6 . NAG E 2 . ? 6.026 53.089 -31.363 1.00 33.87 ? 680 NAG A O6 1 HETATM 4327 O O7 . NAG E 2 . ? 2.974 58.868 -33.125 1.00 31.52 ? 680 NAG A O7 1 HETATM 4328 C C1 . NAG F 2 . ? 6.293 53.571 -34.891 1.00 46.79 ? 690 NAG A C1 1 HETATM 4329 C C2 . NAG F 2 . ? 6.662 52.412 -35.826 1.00 48.94 ? 690 NAG A C2 1 HETATM 4330 C C3 . NAG F 2 . ? 8.084 52.584 -36.352 1.00 51.64 ? 690 NAG A C3 1 HETATM 4331 C C4 . NAG F 2 . ? 8.232 53.950 -37.016 1.00 53.48 ? 690 NAG A C4 1 HETATM 4332 C C5 . NAG F 2 . ? 7.818 55.050 -36.026 1.00 53.97 ? 690 NAG A C5 1 HETATM 4333 C C6 . NAG F 2 . ? 7.838 56.427 -36.664 1.00 55.69 ? 690 NAG A C6 1 HETATM 4334 C C7 . NAG F 2 . ? 5.391 50.524 -35.053 1.00 49.64 ? 690 NAG A C7 1 HETATM 4335 C C8 . NAG F 2 . ? 5.180 49.598 -33.866 1.00 50.06 ? 690 NAG A C8 1 HETATM 4336 N N2 . NAG F 2 . ? 6.560 51.146 -35.130 1.00 48.66 ? 690 NAG A N2 1 HETATM 4337 O O3 . NAG F 2 . ? 8.366 51.560 -37.294 1.00 52.96 ? 690 NAG A O3 1 HETATM 4338 O O4 . NAG F 2 . ? 9.580 54.141 -37.429 1.00 56.35 ? 690 NAG A O4 1 HETATM 4339 O O5 . NAG F 2 . ? 6.464 54.826 -35.566 1.00 50.19 ? 690 NAG A O5 1 HETATM 4340 O O6 . NAG F 2 . ? 6.649 56.661 -37.411 1.00 56.47 ? 690 NAG A O6 1 HETATM 4341 O O7 . NAG F 2 . ? 4.495 50.676 -35.884 1.00 50.41 ? 690 NAG A O7 1 HETATM 4342 C C1 . SUC G 4 . ? 7.110 71.679 -2.801 1.00 25.18 ? 800 SUC A C1 1 HETATM 4343 C C2 . SUC G 4 . ? 6.992 72.569 -1.543 1.00 24.18 ? 800 SUC A C2 1 HETATM 4344 C C3 . SUC G 4 . ? 5.544 73.045 -1.347 1.00 26.36 ? 800 SUC A C3 1 HETATM 4345 C C4 . SUC G 4 . ? 5.140 73.813 -2.601 1.00 24.92 ? 800 SUC A C4 1 HETATM 4346 C C5 . SUC G 4 . ? 5.267 72.905 -3.843 1.00 24.96 ? 800 SUC A C5 1 HETATM 4347 C C6 . SUC G 4 . ? 4.904 73.612 -5.142 1.00 24.23 ? 800 SUC A C6 1 HETATM 4348 O O1 . SUC G 4 . ? 6.365 70.421 -2.595 1.00 23.08 ? 800 SUC A O1 1 HETATM 4349 O O2 . SUC G 4 . ? 7.443 71.831 -0.395 1.00 25.99 ? 800 SUC A O2 1 HETATM 4350 O O3 . SUC G 4 . ? 5.426 73.892 -0.193 1.00 27.57 ? 800 SUC A O3 1 HETATM 4351 O O4 . SUC G 4 . ? 3.796 74.258 -2.452 1.00 24.01 ? 800 SUC A O4 1 HETATM 4352 O O5 . SUC G 4 . ? 6.617 72.417 -3.980 1.00 23.70 ? 800 SUC A O5 1 HETATM 4353 O O6 . SUC G 4 . ? 5.793 74.699 -5.354 1.00 27.35 ? 800 SUC A O6 1 HETATM 4354 C "C1'" . SUC G 4 . ? 7.973 68.449 -2.571 1.00 22.47 ? 800 SUC A "C1'" 1 HETATM 4355 C "C2'" . SUC G 4 . ? 6.827 69.215 -3.270 1.00 22.65 ? 800 SUC A "C2'" 1 HETATM 4356 C "C3'" . SUC G 4 . ? 5.541 68.377 -3.560 1.00 21.73 ? 800 SUC A "C3'" 1 HETATM 4357 C "C4'" . SUC G 4 . ? 5.085 68.964 -4.895 1.00 22.17 ? 800 SUC A "C4'" 1 HETATM 4358 C "C5'" . SUC G 4 . ? 6.458 69.143 -5.545 1.00 22.46 ? 800 SUC A "C5'" 1 HETATM 4359 C "C6'" . SUC G 4 . ? 6.559 70.206 -6.618 1.00 21.39 ? 800 SUC A "C6'" 1 HETATM 4360 O "O1'" . SUC G 4 . ? 7.634 68.018 -1.267 1.00 30.90 ? 800 SUC A "O1'" 1 HETATM 4361 O "O2'" . SUC G 4 . ? 7.366 69.525 -4.539 1.00 22.74 ? 800 SUC A "O2'" 1 HETATM 4362 O "O3'" . SUC G 4 . ? 4.530 68.559 -2.560 1.00 19.17 ? 800 SUC A "O3'" 1 HETATM 4363 O "O4'" . SUC G 4 . ? 4.256 68.062 -5.653 1.00 19.72 ? 800 SUC A "O4'" 1 HETATM 4364 O "O6'" . SUC G 4 . ? 7.816 70.046 -7.269 1.00 20.40 ? 800 SUC A "O6'" 1 HETATM 4365 O O . HOH H 5 . ? 24.321 56.374 5.073 1.00 20.20 ? 1001 HOH A O 1 HETATM 4366 O O . HOH H 5 . ? 7.463 61.148 -22.526 1.00 25.34 ? 1002 HOH A O 1 HETATM 4367 O O . HOH H 5 . ? -16.027 71.184 0.254 1.00 33.33 ? 1003 HOH A O 1 HETATM 4368 O O . HOH H 5 . ? 2.732 45.706 -0.834 1.00 18.59 ? 1004 HOH A O 1 HETATM 4369 O O . HOH H 5 . ? 8.601 39.159 -4.492 1.00 22.01 ? 1005 HOH A O 1 HETATM 4370 O O . HOH H 5 . ? 2.710 55.898 -9.357 1.00 16.78 ? 1006 HOH A O 1 HETATM 4371 O O . HOH H 5 . ? 3.972 58.898 -2.265 1.00 13.19 ? 1007 HOH A O 1 HETATM 4372 O O . HOH H 5 . ? 24.017 64.318 3.485 1.00 25.78 ? 1008 HOH A O 1 HETATM 4373 O O . HOH H 5 . ? 11.375 51.743 8.942 1.00 25.27 ? 1009 HOH A O 1 HETATM 4374 O O . HOH H 5 . ? 29.836 52.902 21.924 1.00 24.61 ? 1010 HOH A O 1 HETATM 4375 O O . HOH H 5 . ? 11.850 58.243 5.568 1.00 18.83 ? 1011 HOH A O 1 HETATM 4376 O O . HOH H 5 . ? 2.316 55.391 -6.597 1.00 16.66 ? 1012 HOH A O 1 HETATM 4377 O O . HOH H 5 . ? -1.917 54.774 -2.828 1.00 17.40 ? 1013 HOH A O 1 HETATM 4378 O O . HOH H 5 . ? 14.636 52.192 8.248 1.00 19.62 ? 1014 HOH A O 1 HETATM 4379 O O . HOH H 5 . ? 1.080 61.295 -3.254 1.00 18.65 ? 1015 HOH A O 1 HETATM 4380 O O . HOH H 5 . ? 24.307 65.904 6.057 1.00 22.58 ? 1016 HOH A O 1 HETATM 4381 O O . HOH H 5 . ? 32.678 61.715 8.834 1.00 20.52 ? 1017 HOH A O 1 HETATM 4382 O O . HOH H 5 . ? 5.028 41.985 3.513 1.00 28.12 ? 1018 HOH A O 1 HETATM 4383 O O . HOH H 5 . ? 9.559 66.425 13.130 1.00 21.85 ? 1019 HOH A O 1 HETATM 4384 O O . HOH H 5 . ? 12.863 61.000 5.387 1.00 13.78 ? 1020 HOH A O 1 HETATM 4385 O O . HOH H 5 . ? 17.560 53.146 -10.871 1.00 22.21 ? 1021 HOH A O 1 HETATM 4386 O O . HOH H 5 . ? 27.202 57.660 18.157 1.00 25.27 ? 1022 HOH A O 1 HETATM 4387 O O . HOH H 5 . ? 14.970 61.067 7.110 1.00 18.66 ? 1023 HOH A O 1 HETATM 4388 O O . HOH H 5 . ? 27.982 65.704 11.618 1.00 24.36 ? 1024 HOH A O 1 HETATM 4389 O O . HOH H 5 . ? 18.385 51.714 -2.224 1.00 22.17 ? 1025 HOH A O 1 HETATM 4390 O O . HOH H 5 . ? 0.918 56.577 -4.480 1.00 24.30 ? 1026 HOH A O 1 HETATM 4391 O O . HOH H 5 . ? 6.952 62.983 1.107 1.00 20.75 ? 1027 HOH A O 1 HETATM 4392 O O . HOH H 5 . ? 38.619 40.945 -6.783 1.00 20.21 ? 1028 HOH A O 1 HETATM 4393 O O . HOH H 5 . ? -5.312 48.095 -7.823 1.00 21.61 ? 1029 HOH A O 1 HETATM 4394 O O . HOH H 5 . ? 18.187 54.920 -8.728 1.00 24.13 ? 1030 HOH A O 1 HETATM 4395 O O . HOH H 5 . ? 19.865 65.833 -11.083 1.00 20.12 ? 1031 HOH A O 1 HETATM 4396 O O . HOH H 5 . ? 33.977 60.509 10.917 1.00 18.67 ? 1032 HOH A O 1 HETATM 4397 O O . HOH H 5 . ? 20.169 43.680 -3.682 1.00 23.71 ? 1033 HOH A O 1 HETATM 4398 O O . HOH H 5 . ? -3.807 50.482 -8.071 1.00 27.51 ? 1034 HOH A O 1 HETATM 4399 O O . HOH H 5 . ? 23.935 57.759 -12.963 1.00 29.92 ? 1035 HOH A O 1 HETATM 4400 O O . HOH H 5 . ? 4.918 44.611 0.440 1.00 17.43 ? 1036 HOH A O 1 HETATM 4401 O O . HOH H 5 . ? 27.258 66.400 3.003 1.00 18.90 ? 1037 HOH A O 1 HETATM 4402 O O . HOH H 5 . ? 13.066 49.804 6.985 1.00 18.48 ? 1038 HOH A O 1 HETATM 4403 O O . HOH H 5 . ? 7.062 75.331 -10.052 1.00 28.18 ? 1039 HOH A O 1 HETATM 4404 O O . HOH H 5 . ? 29.686 71.845 7.663 1.00 32.07 ? 1040 HOH A O 1 HETATM 4405 O O . HOH H 5 . ? 19.950 73.914 -6.413 1.00 27.01 ? 1041 HOH A O 1 HETATM 4406 O O . HOH H 5 . ? 34.607 54.092 -0.266 1.00 27.61 ? 1042 HOH A O 1 HETATM 4407 O O . HOH H 5 . ? 12.222 63.664 -19.627 1.00 24.09 ? 1043 HOH A O 1 HETATM 4408 O O . HOH H 5 . ? 29.313 50.111 24.596 1.00 20.23 ? 1044 HOH A O 1 HETATM 4409 O O . HOH H 5 . ? 2.086 58.760 -4.075 1.00 37.43 ? 1045 HOH A O 1 HETATM 4410 O O . HOH H 5 . ? 5.714 55.670 0.034 1.00 18.19 ? 1046 HOH A O 1 HETATM 4411 O O . HOH H 5 . ? 29.927 66.069 2.505 1.00 20.00 ? 1047 HOH A O 1 HETATM 4412 O O . HOH H 5 . ? 21.600 64.822 -13.028 1.00 25.04 ? 1048 HOH A O 1 HETATM 4413 O O . HOH H 5 . ? 9.205 52.648 -11.853 1.00 15.19 ? 1049 HOH A O 1 HETATM 4414 O O . HOH H 5 . ? 1.158 51.807 14.088 1.00 32.07 ? 1050 HOH A O 1 HETATM 4415 O O . HOH H 5 . ? 1.963 73.724 2.105 1.00 28.65 ? 1051 HOH A O 1 HETATM 4416 O O . HOH H 5 . ? 30.046 66.612 -9.981 1.00 25.43 ? 1052 HOH A O 1 HETATM 4417 O O . HOH H 5 . ? 20.057 52.893 -11.890 1.00 27.70 ? 1053 HOH A O 1 HETATM 4418 O O . HOH H 5 . ? 14.400 61.115 -18.146 1.00 20.98 ? 1054 HOH A O 1 HETATM 4419 O O . HOH H 5 . ? 1.833 67.482 -21.286 1.00 31.43 ? 1055 HOH A O 1 HETATM 4420 O O . HOH H 5 . ? 7.792 43.679 -1.957 1.00 23.75 ? 1056 HOH A O 1 HETATM 4421 O O . HOH H 5 . ? 39.466 52.775 14.661 1.00 22.38 ? 1057 HOH A O 1 HETATM 4422 O O . HOH H 5 . ? 4.033 43.800 -17.350 1.00 30.06 ? 1058 HOH A O 1 HETATM 4423 O O . HOH H 5 . ? 11.696 76.709 -14.381 1.00 30.03 ? 1059 HOH A O 1 HETATM 4424 O O . HOH H 5 . ? 13.659 61.911 21.403 1.00 20.85 ? 1060 HOH A O 1 HETATM 4425 O O . HOH H 5 . ? 5.043 54.949 12.985 1.00 21.69 ? 1061 HOH A O 1 HETATM 4426 O O . HOH H 5 . ? 23.286 63.090 22.453 1.00 25.47 ? 1062 HOH A O 1 HETATM 4427 O O . HOH H 5 . ? 3.540 56.236 14.863 1.00 24.85 ? 1063 HOH A O 1 HETATM 4428 O O . HOH H 5 . ? 14.506 53.612 -2.901 1.00 14.72 ? 1064 HOH A O 1 HETATM 4429 O O . HOH H 5 . ? -1.451 48.496 -7.898 1.00 44.77 ? 1065 HOH A O 1 HETATM 4430 O O . HOH H 5 . ? 24.741 48.347 -16.776 1.00 27.90 ? 1066 HOH A O 1 HETATM 4431 O O . HOH H 5 . ? 3.425 59.984 17.314 1.00 27.88 ? 1067 HOH A O 1 HETATM 4432 O O . HOH H 5 . ? 4.874 50.554 -21.393 1.00 23.76 ? 1068 HOH A O 1 HETATM 4433 O O . HOH H 5 . ? 28.931 62.361 14.091 1.00 24.81 ? 1069 HOH A O 1 HETATM 4434 O O . HOH H 5 . ? 7.926 68.607 4.826 1.00 22.53 ? 1070 HOH A O 1 HETATM 4435 O O . HOH H 5 . ? 6.481 61.628 -4.798 1.00 24.72 ? 1071 HOH A O 1 HETATM 4436 O O . HOH H 5 . ? 29.874 56.601 23.474 1.00 34.56 ? 1072 HOH A O 1 HETATM 4437 O O . HOH H 5 . ? 18.757 60.996 11.631 1.00 24.54 ? 1073 HOH A O 1 HETATM 4438 O O . HOH H 5 . ? 29.438 70.364 -4.965 1.00 24.54 ? 1074 HOH A O 1 HETATM 4439 O O . HOH H 5 . ? 34.205 69.435 -8.869 1.00 37.16 ? 1075 HOH A O 1 HETATM 4440 O O . HOH H 5 . ? 17.135 68.563 -6.264 1.00 21.35 ? 1076 HOH A O 1 HETATM 4441 O O . HOH H 5 . ? 19.869 50.870 25.792 1.00 34.18 ? 1077 HOH A O 1 HETATM 4442 O O . HOH H 5 . ? 26.696 60.815 -15.492 1.00 41.45 ? 1078 HOH A O 1 HETATM 4443 O O . HOH H 5 . ? 0.598 51.447 -5.282 1.00 24.51 ? 1079 HOH A O 1 HETATM 4444 O O . HOH H 5 . ? 33.597 61.282 2.882 1.00 27.69 ? 1080 HOH A O 1 HETATM 4445 O O . HOH H 5 . ? 0.236 53.513 -3.555 1.00 20.04 ? 1081 HOH A O 1 HETATM 4446 O O . HOH H 5 . ? 21.407 60.302 -16.618 1.00 24.58 ? 1082 HOH A O 1 HETATM 4447 O O . HOH H 5 . ? 33.968 48.236 19.701 1.00 26.65 ? 1083 HOH A O 1 HETATM 4448 O O . HOH H 5 . ? 30.814 70.553 -7.348 1.00 29.61 ? 1084 HOH A O 1 HETATM 4449 O O . HOH H 5 . ? -1.600 60.530 11.950 1.00 27.01 ? 1085 HOH A O 1 HETATM 4450 O O . HOH H 5 . ? 0.931 55.747 14.429 1.00 26.52 ? 1086 HOH A O 1 HETATM 4451 O O . HOH H 5 . ? 18.355 69.255 -3.842 1.00 25.37 ? 1087 HOH A O 1 HETATM 4452 O O . HOH H 5 . ? 27.655 38.623 17.667 1.00 31.25 ? 1088 HOH A O 1 HETATM 4453 O O . HOH H 5 . ? 4.925 32.292 -7.592 1.00 76.84 ? 1089 HOH A O 1 HETATM 4454 O O . HOH H 5 . ? 16.813 59.744 13.369 1.00 25.64 ? 1090 HOH A O 1 HETATM 4455 O O . HOH H 5 . ? 18.604 66.643 -18.561 1.00 28.19 ? 1091 HOH A O 1 HETATM 4456 O O . HOH H 5 . ? 18.083 49.058 26.189 1.00 26.53 ? 1092 HOH A O 1 HETATM 4457 O O . HOH H 5 . ? 3.613 52.249 13.069 1.00 24.77 ? 1093 HOH A O 1 HETATM 4458 O O . HOH H 5 . ? 14.982 65.581 18.238 1.00 21.07 ? 1094 HOH A O 1 HETATM 4459 O O . HOH H 5 . ? 15.239 55.165 15.480 1.00 24.39 ? 1095 HOH A O 1 HETATM 4460 O O . HOH H 5 . ? 1.245 57.286 -25.384 1.00 23.98 ? 1096 HOH A O 1 HETATM 4461 O O . HOH H 5 . ? 21.032 55.751 31.438 1.00 26.11 ? 1097 HOH A O 1 HETATM 4462 O O . HOH H 5 . ? 3.269 57.853 -27.328 1.00 23.02 ? 1098 HOH A O 1 HETATM 4463 O O . HOH H 5 . ? -1.233 41.282 -5.438 1.00 28.96 ? 1099 HOH A O 1 HETATM 4464 O O . HOH H 5 . ? 21.023 40.677 -1.506 1.00 19.34 ? 1100 HOH A O 1 HETATM 4465 O O . HOH H 5 . ? 1.603 52.866 -10.076 1.00 22.97 ? 1101 HOH A O 1 HETATM 4466 O O . HOH H 5 . ? 34.134 61.785 14.254 1.00 32.63 ? 1102 HOH A O 1 HETATM 4467 O O . HOH H 5 . ? 23.561 65.759 22.101 1.00 33.28 ? 1103 HOH A O 1 HETATM 4468 O O . HOH H 5 . ? -13.250 53.245 -13.504 1.00 25.60 ? 1104 HOH A O 1 HETATM 4469 O O . HOH H 5 . ? 16.695 51.507 26.961 1.00 23.88 ? 1105 HOH A O 1 HETATM 4470 O O . HOH H 5 . ? 13.402 64.378 20.307 1.00 19.84 ? 1106 HOH A O 1 HETATM 4471 O O . HOH H 5 . ? 2.681 78.543 -9.547 1.00 25.82 ? 1107 HOH A O 1 HETATM 4472 O O . HOH H 5 . ? -2.180 50.437 -10.653 1.00 30.81 ? 1108 HOH A O 1 HETATM 4473 O O . HOH H 5 . ? 5.524 70.272 7.647 1.00 30.06 ? 1109 HOH A O 1 HETATM 4474 O O . HOH H 5 . ? -4.964 74.913 4.237 1.00 28.36 ? 1110 HOH A O 1 HETATM 4475 O O . HOH H 5 . ? 10.433 38.056 -1.590 1.00 35.36 ? 1111 HOH A O 1 HETATM 4476 O O . HOH H 5 . ? 23.534 41.373 -1.074 1.00 28.23 ? 1112 HOH A O 1 HETATM 4477 O O . HOH H 5 . ? 21.878 72.682 -2.663 1.00 23.50 ? 1113 HOH A O 1 HETATM 4478 O O . HOH H 5 . ? -12.219 50.890 -14.190 1.00 25.44 ? 1114 HOH A O 1 HETATM 4479 O O . HOH H 5 . ? -12.905 54.895 -15.716 1.00 30.35 ? 1115 HOH A O 1 HETATM 4480 O O . HOH H 5 . ? 5.582 58.676 -30.928 1.00 30.24 ? 1116 HOH A O 1 HETATM 4481 O O . HOH H 5 . ? 24.410 38.951 -2.213 1.00 33.38 ? 1117 HOH A O 1 HETATM 4482 O O . HOH H 5 . ? -11.519 51.115 -16.986 1.00 27.71 ? 1118 HOH A O 1 HETATM 4483 O O . HOH H 5 . ? 35.700 53.857 -7.627 1.00 32.14 ? 1119 HOH A O 1 HETATM 4484 O O . HOH H 5 . ? 16.425 48.688 -19.286 1.00 27.69 ? 1120 HOH A O 1 HETATM 4485 O O . HOH H 5 . ? 3.051 64.444 -23.816 1.00 29.62 ? 1121 HOH A O 1 HETATM 4486 O O . HOH H 5 . ? 2.166 60.183 19.960 1.00 29.85 ? 1122 HOH A O 1 HETATM 4487 O O . HOH H 5 . ? -15.935 67.370 -3.493 1.00 40.86 ? 1123 HOH A O 1 HETATM 4488 O O . HOH H 5 . ? -7.541 74.941 -20.984 1.00 33.67 ? 1124 HOH A O 1 HETATM 4489 O O . HOH H 5 . ? 42.783 59.234 -1.609 1.00 33.19 ? 1125 HOH A O 1 HETATM 4490 O O . HOH H 5 . ? -15.893 51.497 -11.108 1.00 31.24 ? 1126 HOH A O 1 HETATM 4491 O O . HOH H 5 . ? -5.705 46.810 6.671 1.00 25.21 ? 1127 HOH A O 1 HETATM 4492 O O . HOH H 5 . ? 15.870 58.013 27.603 1.00 31.62 ? 1128 HOH A O 1 HETATM 4493 O O . HOH H 5 . ? 30.813 56.449 -12.842 1.00 38.56 ? 1129 HOH A O 1 HETATM 4494 O O . HOH H 5 . ? -2.763 75.945 5.717 1.00 34.91 ? 1130 HOH A O 1 HETATM 4495 O O . HOH H 5 . ? 4.850 65.446 -25.881 1.00 35.16 ? 1131 HOH A O 1 HETATM 4496 O O . HOH H 5 . ? -7.164 67.288 -24.110 1.00 27.22 ? 1132 HOH A O 1 HETATM 4497 O O . HOH H 5 . ? 11.900 58.847 14.193 1.00 22.11 ? 1133 HOH A O 1 HETATM 4498 O O . HOH H 5 . ? 4.800 78.736 -10.927 1.00 32.99 ? 1134 HOH A O 1 HETATM 4499 O O . HOH H 5 . ? -0.490 60.249 19.274 1.00 37.00 ? 1135 HOH A O 1 HETATM 4500 O O . HOH H 5 . ? 40.104 58.942 11.118 1.00 35.80 ? 1136 HOH A O 1 HETATM 4501 O O . HOH H 5 . ? 40.633 51.089 -0.227 1.00 25.62 ? 1137 HOH A O 1 HETATM 4502 O O . HOH H 5 . ? 6.396 60.885 -29.794 1.00 40.65 ? 1138 HOH A O 1 HETATM 4503 O O . HOH H 5 . ? 37.728 56.295 -6.622 1.00 33.59 ? 1139 HOH A O 1 HETATM 4504 O O . HOH H 5 . ? -4.213 51.555 -29.444 1.00 27.92 ? 1140 HOH A O 1 HETATM 4505 O O . HOH H 5 . ? 21.586 67.910 21.602 1.00 37.82 ? 1141 HOH A O 1 HETATM 4506 O O . HOH H 5 . ? 26.095 38.681 -6.371 1.00 31.95 ? 1142 HOH A O 1 HETATM 4507 O O . HOH H 5 . ? -3.559 57.820 -9.709 1.00 26.96 ? 1143 HOH A O 1 HETATM 4508 O O . HOH H 5 . ? 10.398 60.970 -26.157 1.00 43.37 ? 1144 HOH A O 1 HETATM 4509 O O . HOH H 5 . ? 41.795 55.073 18.589 1.00 35.68 ? 1145 HOH A O 1 HETATM 4510 O O . HOH H 5 . ? 31.548 50.915 -15.784 1.00 39.61 ? 1146 HOH A O 1 HETATM 4511 O O . HOH H 5 . ? 18.649 42.313 25.147 1.00 36.15 ? 1147 HOH A O 1 HETATM 4512 O O . HOH H 5 . ? -4.504 66.941 -24.219 1.00 30.30 ? 1148 HOH A O 1 HETATM 4513 O O . HOH H 5 . ? 16.047 75.320 -5.411 1.00 31.08 ? 1149 HOH A O 1 HETATM 4514 O O . HOH H 5 . ? 22.159 44.611 6.410 1.00 20.82 ? 1150 HOH A O 1 HETATM 4515 O O . HOH H 5 . ? 13.340 51.987 11.134 1.00 34.69 ? 1151 HOH A O 1 HETATM 4516 O O . HOH H 5 . ? 41.284 35.344 13.258 1.00 35.99 ? 1152 HOH A O 1 HETATM 4517 O O . HOH H 5 . ? 26.066 55.559 -15.457 1.00 37.43 ? 1153 HOH A O 1 HETATM 4518 O O . HOH H 5 . ? 36.973 59.263 22.588 1.00 31.88 ? 1154 HOH A O 1 HETATM 4519 O O . HOH H 5 . ? 26.990 71.388 8.357 1.00 36.40 ? 1155 HOH A O 1 HETATM 4520 O O . HOH H 5 . ? 18.413 79.381 -10.818 1.00 27.92 ? 1156 HOH A O 1 HETATM 4521 O O . HOH H 5 . ? 12.663 61.434 14.530 1.00 22.89 ? 1157 HOH A O 1 HETATM 4522 O O . HOH H 5 . ? -7.990 73.558 -18.122 1.00 41.03 ? 1158 HOH A O 1 HETATM 4523 O O . HOH H 5 . ? 11.356 63.732 18.610 1.00 28.66 ? 1159 HOH A O 1 HETATM 4524 O O . HOH H 5 . ? 18.603 75.407 -4.832 1.00 38.09 ? 1160 HOH A O 1 HETATM 4525 O O . HOH H 5 . ? 24.841 79.019 -2.711 1.00 39.81 ? 1161 HOH A O 1 HETATM 4526 O O . HOH H 5 . ? 42.052 37.762 13.046 1.00 30.91 ? 1162 HOH A O 1 HETATM 4527 O O . HOH H 5 . ? -8.339 75.631 -12.669 1.00 32.75 ? 1163 HOH A O 1 HETATM 4528 O O . HOH H 5 . ? 15.699 65.337 3.176 1.00 31.81 ? 1164 HOH A O 1 HETATM 4529 O O . HOH H 5 . ? -9.810 50.217 10.677 1.00 34.97 ? 1165 HOH A O 1 HETATM 4530 O O . HOH H 5 . ? 36.886 68.238 -11.062 1.00 46.44 ? 1166 HOH A O 1 HETATM 4531 O O . HOH H 5 . ? -17.628 58.826 -10.109 1.00 36.95 ? 1167 HOH A O 1 HETATM 4532 O O . HOH H 5 . ? -10.061 75.144 -16.574 1.00 34.57 ? 1168 HOH A O 1 HETATM 4533 O O . HOH H 5 . ? 35.437 52.347 26.770 1.00 33.23 ? 1169 HOH A O 1 HETATM 4534 O O . HOH H 5 . ? -1.169 75.176 -24.484 1.00 52.20 ? 1170 HOH A O 1 HETATM 4535 O O . HOH H 5 . ? 19.532 51.927 -21.034 1.00 31.22 ? 1171 HOH A O 1 HETATM 4536 O O . HOH H 5 . ? 17.084 63.170 10.530 1.00 47.88 ? 1172 HOH A O 1 HETATM 4537 O O . HOH H 5 . ? 13.542 67.528 2.892 1.00 38.37 ? 1173 HOH A O 1 HETATM 4538 O O . HOH H 5 . ? 2.472 50.448 -24.401 1.00 31.22 ? 1174 HOH A O 1 HETATM 4539 O O . HOH H 5 . ? 4.799 71.924 11.703 1.00 42.76 ? 1175 HOH A O 1 HETATM 4540 O O . HOH H 5 . ? -11.012 76.303 -0.957 1.00 39.28 ? 1176 HOH A O 1 HETATM 4541 O O . HOH H 5 . ? -11.741 63.410 2.959 1.00 34.54 ? 1177 HOH A O 1 HETATM 4542 O O . HOH H 5 . ? 38.042 60.103 -7.580 1.00 51.71 ? 1178 HOH A O 1 HETATM 4543 O O . HOH H 5 . ? 30.954 74.442 -1.194 1.00 35.81 ? 1179 HOH A O 1 HETATM 4544 O O . HOH H 5 . ? 31.500 68.927 -9.600 1.00 27.68 ? 1180 HOH A O 1 HETATM 4545 O O . HOH H 5 . ? 44.357 41.243 7.879 1.00 31.95 ? 1181 HOH A O 1 HETATM 4546 O O . HOH H 5 . ? 41.169 41.894 -6.139 1.00 28.47 ? 1182 HOH A O 1 HETATM 4547 O O . HOH H 5 . ? -7.203 50.591 -22.870 1.00 39.76 ? 1183 HOH A O 1 HETATM 4548 O O . HOH H 5 . ? 11.772 63.779 15.476 1.00 26.77 ? 1184 HOH A O 1 HETATM 4549 O O . HOH H 5 . ? 22.622 77.041 -0.792 1.00 39.88 ? 1185 HOH A O 1 HETATM 4550 O O . HOH H 5 . ? 3.250 48.146 -25.383 1.00 30.62 ? 1186 HOH A O 1 HETATM 4551 O O . HOH H 5 . ? 34.502 59.833 -6.637 1.00 45.49 ? 1187 HOH A O 1 HETATM 4552 O O . HOH H 5 . ? -13.309 71.733 -14.018 1.00 38.01 ? 1188 HOH A O 1 HETATM 4553 O O . HOH H 5 . ? 42.294 42.571 -3.681 1.00 37.48 ? 1189 HOH A O 1 HETATM 4554 O O . HOH H 5 . ? 14.082 78.227 -13.516 1.00 24.99 ? 1190 HOH A O 1 HETATM 4555 O O . HOH H 5 . ? 16.025 41.793 9.068 1.00 45.40 ? 1191 HOH A O 1 HETATM 4556 O O . HOH H 5 . ? 3.038 58.468 -30.028 1.00 22.88 ? 1192 HOH A O 1 HETATM 4557 O O . HOH H 5 . ? -5.758 80.426 -0.439 1.00 38.28 ? 1193 HOH A O 1 HETATM 4558 O O . HOH H 5 . ? 13.976 54.536 21.957 1.00 17.03 ? 1194 HOH A O 1 HETATM 4559 O O . HOH H 5 . ? 2.392 39.862 12.053 1.00 40.70 ? 1195 HOH A O 1 HETATM 4560 O O . HOH H 5 . ? 43.682 41.929 -1.140 1.00 31.91 ? 1196 HOH A O 1 HETATM 4561 O O . HOH H 5 . ? 14.229 58.125 15.431 1.00 30.92 ? 1197 HOH A O 1 HETATM 4562 O O . HOH H 5 . ? 6.817 71.412 -26.069 1.00 53.81 ? 1198 HOH A O 1 HETATM 4563 O O . HOH H 5 . ? -1.160 62.919 19.292 1.00 34.97 ? 1199 HOH A O 1 HETATM 4564 O O . HOH H 5 . ? 30.476 59.241 -11.967 1.00 43.10 ? 1200 HOH A O 1 HETATM 4565 O O . HOH H 5 . ? 12.212 80.168 -12.378 1.00 35.77 ? 1201 HOH A O 1 HETATM 4566 O O . HOH H 5 . ? 22.986 45.654 -15.784 1.00 43.29 ? 1202 HOH A O 1 HETATM 4567 O O . HOH H 5 . ? 17.968 68.534 2.254 1.00 30.78 ? 1203 HOH A O 1 HETATM 4568 O O . HOH H 5 . ? 10.802 68.052 14.975 1.00 38.99 ? 1204 HOH A O 1 HETATM 4569 O O . HOH H 5 . ? 6.681 77.649 -8.600 1.00 40.96 ? 1205 HOH A O 1 HETATM 4570 O O . HOH H 5 . ? 8.100 46.315 -24.910 1.00 27.75 ? 1206 HOH A O 1 HETATM 4571 O O . HOH H 5 . ? 35.833 75.137 -0.008 1.00 49.54 ? 1207 HOH A O 1 HETATM 4572 O O . HOH H 5 . ? 20.711 44.975 -14.182 1.00 39.24 ? 1208 HOH A O 1 HETATM 4573 O O . HOH H 5 . ? 21.280 76.382 -13.005 1.00 30.16 ? 1209 HOH A O 1 HETATM 4574 O O . HOH H 5 . ? 20.436 78.976 -12.599 1.00 34.36 ? 1210 HOH A O 1 HETATM 4575 O O . HOH H 5 . ? 0.554 65.486 15.712 1.00 40.67 ? 1211 HOH A O 1 HETATM 4576 O O . HOH H 5 . ? 15.010 40.817 15.935 1.00 42.68 ? 1212 HOH A O 1 HETATM 4577 O O . HOH H 5 . ? -4.914 60.987 13.743 1.00 34.02 ? 1213 HOH A O 1 HETATM 4578 O O . HOH H 5 . ? 5.130 79.139 -14.706 1.00 33.39 ? 1214 HOH A O 1 HETATM 4579 O O . HOH H 5 . ? 45.177 49.983 12.578 1.00 38.54 ? 1215 HOH A O 1 HETATM 4580 O O . HOH H 5 . ? 8.236 50.892 -31.006 1.00 37.44 ? 1216 HOH A O 1 HETATM 4581 O O . HOH H 5 . ? 23.784 42.818 5.101 1.00 39.69 ? 1217 HOH A O 1 HETATM 4582 O O . HOH H 5 . ? 23.642 75.668 -14.296 1.00 39.85 ? 1218 HOH A O 1 HETATM 4583 O O . HOH H 5 . ? -5.857 66.557 13.128 1.00 36.67 ? 1219 HOH A O 1 HETATM 4584 O O . HOH H 5 . ? 15.332 60.924 15.297 1.00 32.41 ? 1220 HOH A O 1 HETATM 4585 O O . HOH H 5 . ? 0.347 75.568 8.066 1.00 35.80 ? 1221 HOH A O 1 HETATM 4586 O O . HOH H 5 . ? 25.659 67.559 -15.732 1.00 41.83 ? 1222 HOH A O 1 HETATM 4587 O O . HOH H 5 . ? 28.422 39.702 5.243 1.00 42.45 ? 1223 HOH A O 1 HETATM 4588 O O . HOH H 5 . ? 7.292 35.512 1.200 1.00 43.76 ? 1224 HOH A O 1 HETATM 4589 O O . HOH H 5 . ? 9.000 52.230 18.019 1.00 56.03 ? 1225 HOH A O 1 HETATM 4590 O O . HOH H 5 . ? 46.041 43.576 7.692 1.00 30.65 ? 1226 HOH A O 1 HETATM 4591 O O . HOH H 5 . ? 43.735 49.005 -3.940 1.00 24.43 ? 1227 HOH A O 1 HETATM 4592 O O . HOH H 5 . ? 5.371 76.709 -19.338 1.00 38.11 ? 1228 HOH A O 1 HETATM 4593 O O . HOH H 5 . ? -11.139 75.630 -12.657 1.00 39.05 ? 1229 HOH A O 1 HETATM 4594 O O . HOH H 5 . ? -17.317 65.537 -9.419 1.00 48.51 ? 1230 HOH A O 1 HETATM 4595 O O . HOH H 5 . ? 46.920 47.731 3.928 1.00 24.56 ? 1231 HOH A O 1 HETATM 4596 O O . HOH H 5 . ? 48.533 46.070 3.774 1.00 27.89 ? 1232 HOH A O 1 HETATM 4597 O O . HOH H 5 . ? 18.323 61.914 -28.644 1.00 39.93 ? 1233 HOH A O 1 HETATM 4598 O O . HOH H 5 . ? 16.664 67.368 15.008 1.00 36.78 ? 1234 HOH A O 1 HETATM 4599 O O . HOH H 5 . ? 15.978 42.739 -3.406 1.00 26.71 ? 1235 HOH A O 1 HETATM 4600 O O . HOH H 5 . ? 14.984 63.563 5.065 1.00 32.09 ? 1236 HOH A O 1 HETATM 4601 O O . HOH H 5 . ? -6.146 57.669 11.109 1.00 24.88 ? 1237 HOH A O 1 HETATM 4602 O O . HOH H 5 . ? 10.907 68.943 -3.322 1.00 36.26 ? 1238 HOH A O 1 HETATM 4603 O O . HOH H 5 . ? 14.739 50.920 29.017 1.00 27.26 ? 1239 HOH A O 1 HETATM 4604 O O . HOH H 5 . ? 14.859 48.837 13.099 1.00 32.64 ? 1240 HOH A O 1 HETATM 4605 O O . HOH H 5 . ? 44.640 43.632 -3.910 1.00 31.67 ? 1241 HOH A O 1 HETATM 4606 O O . HOH H 5 . ? 8.837 54.893 -28.513 1.00 31.68 ? 1242 HOH A O 1 HETATM 4607 O O . HOH H 5 . ? 5.641 46.955 -24.211 1.00 32.98 ? 1243 HOH A O 1 HETATM 4608 O O . HOH H 5 . ? 21.805 42.364 11.736 1.00 28.02 ? 1244 HOH A O 1 HETATM 4609 O O . HOH H 5 . ? 9.180 70.193 1.915 1.00 33.05 ? 1245 HOH A O 1 HETATM 4610 O O . HOH H 5 . ? 23.685 56.194 31.673 1.00 28.06 ? 1246 HOH A O 1 HETATM 4611 O O . HOH H 5 . ? 25.726 40.532 17.828 1.00 34.94 ? 1247 HOH A O 1 HETATM 4612 O O . HOH H 5 . ? 29.779 72.749 -8.147 1.00 37.45 ? 1248 HOH A O 1 HETATM 4613 O O . HOH H 5 . ? 17.351 51.682 32.504 1.00 29.95 ? 1249 HOH A O 1 HETATM 4614 O O . HOH H 5 . ? 2.859 73.211 5.560 1.00 44.87 ? 1250 HOH A O 1 HETATM 4615 O O . HOH H 5 . ? 11.485 66.642 11.486 1.00 33.02 ? 1251 HOH A O 1 HETATM 4616 O O . HOH H 5 . ? 13.511 56.607 17.760 1.00 42.27 ? 1252 HOH A O 1 HETATM 4617 O O . HOH H 5 . ? -12.206 69.167 -2.871 1.00 29.57 ? 1253 HOH A O 1 HETATM 4618 O O . HOH H 5 . ? 2.788 75.755 0.123 1.00 39.81 ? 1254 HOH A O 1 HETATM 4619 O O . HOH H 5 . ? 15.879 69.683 0.950 1.00 36.83 ? 1255 HOH A O 1 HETATM 4620 O O . HOH H 5 . ? 41.363 55.217 13.954 1.00 33.16 ? 1256 HOH A O 1 HETATM 4621 O O . HOH H 5 . ? 37.604 42.944 23.870 1.00 33.27 ? 1257 HOH A O 1 HETATM 4622 O O . HOH H 5 . ? 2.702 49.117 -11.784 1.00 27.67 ? 1258 HOH A O 1 HETATM 4623 O O . HOH H 5 . ? 2.444 45.940 -12.290 1.00 42.80 ? 1259 HOH A O 1 HETATM 4624 O O . HOH H 5 . ? -14.519 65.403 -10.303 1.00 37.15 ? 1260 HOH A O 1 HETATM 4625 O O . HOH H 5 . ? -10.458 76.838 -4.571 1.00 41.47 ? 1261 HOH A O 1 HETATM 4626 O O . HOH H 5 . ? 5.045 69.902 4.868 1.00 38.30 ? 1262 HOH A O 1 HETATM 4627 O O . HOH H 5 . ? -4.848 58.298 13.435 1.00 31.42 ? 1263 HOH A O 1 HETATM 4628 O O . HOH H 5 . ? 1.019 50.809 -7.996 1.00 24.05 ? 1264 HOH A O 1 HETATM 4629 O O . HOH H 5 . ? 11.400 58.222 21.536 1.00 30.77 ? 1265 HOH A O 1 HETATM 4630 O O . HOH H 5 . ? 13.006 38.779 -2.088 1.00 40.83 ? 1266 HOH A O 1 HETATM 4631 O O . HOH H 5 . ? 9.401 41.535 -2.404 1.00 37.66 ? 1267 HOH A O 1 HETATM 4632 O O . HOH H 5 . ? 23.351 36.314 13.080 1.00 36.81 ? 1268 HOH A O 1 HETATM 4633 O O . HOH H 5 . ? -6.329 47.741 -0.348 1.00 41.77 ? 1269 HOH A O 1 HETATM 4634 O O . HOH H 5 . ? 24.029 66.158 19.282 1.00 28.87 ? 1270 HOH A O 1 HETATM 4635 O O . HOH H 5 . ? -9.864 76.546 7.860 1.00 42.30 ? 1271 HOH A O 1 HETATM 4636 O O . HOH H 5 . ? 35.085 71.741 -11.772 1.00 69.16 ? 1272 HOH A O 1 HETATM 4637 O O . HOH H 5 . ? 1.340 77.642 -19.984 1.00 36.13 ? 1273 HOH A O 1 HETATM 4638 O O . HOH H 5 . ? 0.819 60.085 -30.175 1.00 29.71 ? 1274 HOH A O 1 HETATM 4639 O O . HOH H 5 . ? 17.295 46.124 20.350 1.00 46.91 ? 1275 HOH A O 1 HETATM 4640 O O . HOH H 5 . ? 8.243 75.389 -3.688 1.00 37.01 ? 1276 HOH A O 1 HETATM 4641 O O . HOH H 5 . ? 31.798 61.983 -3.780 1.00 48.28 ? 1277 HOH A O 1 HETATM 4642 O O . HOH H 5 . ? -1.608 41.134 -8.408 1.00 36.34 ? 1278 HOH A O 1 HETATM 4643 O O . HOH H 5 . ? -6.562 75.680 6.328 1.00 38.09 ? 1279 HOH A O 1 HETATM 4644 O O . HOH H 5 . ? 14.493 65.265 -18.281 1.00 41.77 ? 1280 HOH A O 1 HETATM 4645 O O . HOH H 5 . ? 39.545 63.272 9.805 1.00 45.73 ? 1281 HOH A O 1 HETATM 4646 O O . HOH H 5 . ? 0.891 66.204 -23.523 1.00 43.48 ? 1282 HOH A O 1 HETATM 4647 O O . HOH H 5 . ? 16.733 70.576 -1.624 1.00 35.05 ? 1283 HOH A O 1 HETATM 4648 O O . HOH H 5 . ? 4.582 50.026 14.477 1.00 42.95 ? 1284 HOH A O 1 HETATM 4649 O O . HOH H 5 . ? 21.933 67.732 18.384 1.00 36.27 ? 1285 HOH A O 1 HETATM 4650 O O . HOH H 5 . ? 14.396 74.588 -3.428 1.00 33.74 ? 1286 HOH A O 1 HETATM 4651 O O . HOH H 5 . ? 33.822 34.323 12.526 1.00 49.11 ? 1287 HOH A O 1 HETATM 4652 O O . HOH H 5 . ? 8.529 49.824 16.938 1.00 51.97 ? 1288 HOH A O 1 HETATM 4653 O O . HOH H 5 . ? -0.957 67.122 19.494 1.00 35.64 ? 1289 HOH A O 1 HETATM 4654 O O . HOH H 5 . ? -9.347 47.540 -1.791 1.00 45.50 ? 1290 HOH A O 1 HETATM 4655 O O . HOH H 5 . ? -3.698 69.792 -23.763 1.00 45.01 ? 1291 HOH A O 1 HETATM 4656 O O . HOH H 5 . ? -0.978 77.647 8.993 1.00 53.62 ? 1292 HOH A O 1 HETATM 4657 O O . HOH H 5 . ? 42.028 62.162 12.780 1.00 43.30 ? 1293 HOH A O 1 HETATM 4658 O O . HOH H 5 . ? 0.647 46.388 -14.976 1.00 35.31 ? 1294 HOH A O 1 HETATM 4659 O O . HOH H 5 . ? 18.059 43.469 22.574 1.00 45.37 ? 1295 HOH A O 1 HETATM 4660 O O . HOH H 5 . ? 13.266 45.964 -27.657 1.00 55.99 ? 1296 HOH A O 1 HETATM 4661 O O . HOH H 5 . ? 13.631 42.856 -14.033 1.00 36.68 ? 1297 HOH A O 1 HETATM 4662 O O . HOH H 5 . ? 40.917 48.565 24.653 1.00 38.87 ? 1298 HOH A O 1 HETATM 4663 O O . HOH H 5 . ? 0.979 44.451 11.661 1.00 39.40 ? 1299 HOH A O 1 HETATM 4664 O O . HOH H 5 . ? 7.548 73.269 1.980 1.00 48.89 ? 1300 HOH A O 1 HETATM 4665 O O . HOH H 5 . ? 11.874 40.235 -0.127 1.00 45.38 ? 1301 HOH A O 1 HETATM 4666 O O . HOH H 5 . ? 19.510 41.191 27.662 1.00 46.85 ? 1302 HOH A O 1 HETATM 4667 O O . HOH H 5 . ? -8.160 70.379 11.308 1.00 39.34 ? 1303 HOH A O 1 HETATM 4668 O O . HOH H 5 . ? 14.076 56.923 21.134 1.00 31.97 ? 1304 HOH A O 1 HETATM 4669 O O . HOH H 5 . ? 16.007 49.960 20.564 1.00 49.15 ? 1305 HOH A O 1 HETATM 4670 O O . HOH H 5 . ? 14.067 65.435 15.604 1.00 30.61 ? 1306 HOH A O 1 HETATM 4671 O O . HOH H 5 . ? -3.392 48.985 -29.555 1.00 33.61 ? 1307 HOH A O 1 HETATM 4672 O O . HOH H 5 . ? 8.008 62.771 -27.027 1.00 62.97 ? 1308 HOH A O 1 HETATM 4673 O O . HOH H 5 . ? 25.200 64.056 -18.179 1.00 37.60 ? 1309 HOH A O 1 HETATM 4674 O O . HOH H 5 . ? -2.986 68.676 19.457 1.00 42.78 ? 1310 HOH A O 1 HETATM 4675 O O . HOH H 5 . ? -14.179 68.672 -13.556 1.00 41.72 ? 1311 HOH A O 1 HETATM 4676 O O . HOH H 5 . ? 15.736 64.046 12.934 1.00 43.47 ? 1312 HOH A O 1 HETATM 4677 O O . HOH H 5 . ? 32.414 63.005 18.225 1.00 34.09 ? 1313 HOH A O 1 HETATM 4678 O O . HOH H 5 . ? 6.222 53.797 15.869 1.00 41.09 ? 1314 HOH A O 1 HETATM 4679 O O . HOH H 5 . ? 42.114 73.837 -4.596 1.00 58.61 ? 1315 HOH A O 1 HETATM 4680 O O . HOH H 5 . ? -2.949 65.936 -26.223 1.00 33.72 ? 1316 HOH A O 1 HETATM 4681 O O . HOH H 5 . ? 28.807 52.411 31.380 1.00 35.62 ? 1317 HOH A O 1 HETATM 4682 O O . HOH H 5 . ? -0.877 74.197 14.560 1.00 40.09 ? 1318 HOH A O 1 HETATM 4683 O O . HOH H 5 . ? 45.188 48.159 6.470 1.00 39.80 ? 1319 HOH A O 1 HETATM 4684 O O . HOH H 5 . ? 24.595 73.486 7.340 1.00 44.15 ? 1320 HOH A O 1 HETATM 4685 O O . HOH H 5 . ? 20.275 68.039 7.481 1.00 40.13 ? 1321 HOH A O 1 HETATM 4686 O O . HOH H 5 . ? 22.665 58.569 -25.391 1.00 44.15 ? 1322 HOH A O 1 HETATM 4687 O O . HOH H 5 . ? 33.278 50.704 -10.976 1.00 41.53 ? 1323 HOH A O 1 HETATM 4688 O O . HOH H 5 . ? 3.673 38.698 14.039 1.00 64.51 ? 1324 HOH A O 1 HETATM 4689 O O . HOH H 5 . ? 6.707 39.309 6.821 1.00 40.21 ? 1325 HOH A O 1 HETATM 4690 O O . HOH H 5 . ? 2.127 52.358 20.938 1.00 42.93 ? 1326 HOH A O 1 HETATM 4691 O O . HOH H 5 . ? -19.836 59.495 -12.255 1.00 42.80 ? 1327 HOH A O 1 HETATM 4692 O O . HOH H 5 . ? 14.154 46.476 30.010 1.00 45.54 ? 1328 HOH A O 1 HETATM 4693 O O . HOH H 5 . ? -7.555 44.828 4.444 1.00 43.66 ? 1329 HOH A O 1 HETATM 4694 O O . HOH H 5 . ? 15.666 54.399 -27.573 1.00 44.27 ? 1330 HOH A O 1 HETATM 4695 O O . HOH H 5 . ? 27.976 58.828 -14.310 1.00 41.09 ? 1331 HOH A O 1 HETATM 4696 O O . HOH H 5 . ? 11.737 55.733 14.681 1.00 38.56 ? 1332 HOH A O 1 HETATM 4697 O O . HOH H 5 . ? 29.251 77.632 -2.054 1.00 40.83 ? 1333 HOH A O 1 HETATM 4698 O O . HOH H 5 . ? -19.033 61.460 2.990 1.00 43.60 ? 1334 HOH A O 1 HETATM 4699 O O . HOH H 5 . ? -2.933 64.740 15.931 1.00 46.70 ? 1335 HOH A O 1 HETATM 4700 O O . HOH H 5 . ? 4.126 73.514 9.614 1.00 47.15 ? 1336 HOH A O 1 HETATM 4701 O O . HOH H 5 . ? 5.884 58.237 -33.712 1.00 51.84 ? 1337 HOH A O 1 HETATM 4702 O O . HOH H 5 . ? 0.437 50.646 -11.263 1.00 35.33 ? 1338 HOH A O 1 HETATM 4703 O O . HOH H 5 . ? 0.657 74.888 5.523 1.00 39.71 ? 1339 HOH A O 1 HETATM 4704 O O . HOH H 5 . ? 14.554 41.571 -1.367 1.00 38.41 ? 1340 HOH A O 1 HETATM 4705 O O . HOH H 5 . ? 22.438 72.825 -16.217 1.00 43.63 ? 1341 HOH A O 1 HETATM 4706 O O . HOH H 5 . ? 10.778 43.934 -17.961 1.00 37.11 ? 1342 HOH A O 1 HETATM 4707 O O . HOH H 5 . ? 18.145 46.491 -19.546 1.00 38.55 ? 1343 HOH A O 1 HETATM 4708 O O . HOH H 5 . ? 6.680 54.503 19.221 1.00 38.33 ? 1344 HOH A O 1 HETATM 4709 O O . HOH H 5 . ? 45.057 43.521 10.815 1.00 39.16 ? 1345 HOH A O 1 HETATM 4710 O O . HOH H 5 . ? -1.917 43.742 -10.188 1.00 38.54 ? 1346 HOH A O 1 HETATM 4711 O O . HOH H 5 . ? 32.201 49.159 29.680 1.00 38.42 ? 1347 HOH A O 1 HETATM 4712 O O . HOH H 5 . ? 27.617 40.546 -12.682 1.00 36.76 ? 1348 HOH A O 1 HETATM 4713 O O . HOH H 5 . ? 4.120 77.042 -4.682 1.00 41.95 ? 1349 HOH A O 1 HETATM 4714 O O . HOH H 5 . ? -2.111 48.704 -31.899 1.00 39.30 ? 1350 HOH A O 1 HETATM 4715 O O . HOH H 5 . ? -17.101 54.427 1.552 1.00 46.06 ? 1351 HOH A O 1 HETATM 4716 O O . HOH H 5 . ? -7.128 70.097 -23.425 1.00 38.68 ? 1352 HOH A O 1 HETATM 4717 O O . HOH H 5 . ? 30.733 39.104 -9.044 1.00 38.72 ? 1353 HOH A O 1 HETATM 4718 O O . HOH H 5 . ? 31.157 75.679 6.285 1.00 45.14 ? 1354 HOH A O 1 HETATM 4719 O O . HOH H 5 . ? 46.298 50.490 4.279 1.00 42.82 ? 1355 HOH A O 1 HETATM 4720 O O . HOH H 5 . ? 12.522 40.106 6.345 1.00 39.38 ? 1356 HOH A O 1 HETATM 4721 O O . HOH H 5 . ? 43.013 44.422 13.934 1.00 40.42 ? 1357 HOH A O 1 HETATM 4722 O O . HOH H 5 . ? -0.650 55.704 -34.035 1.00 46.77 ? 1358 HOH A O 1 HETATM 4723 O O . HOH H 5 . ? 31.134 72.582 5.316 1.00 39.91 ? 1359 HOH A O 1 HETATM 4724 O O . HOH H 5 . ? 19.725 39.771 -10.019 1.00 39.23 ? 1360 HOH A O 1 HETATM 4725 O O . HOH H 5 . ? -0.828 80.898 -16.108 1.00 50.12 ? 1361 HOH A O 1 HETATM 4726 O O . HOH H 5 . ? 3.045 40.786 -15.479 1.00 44.24 ? 1362 HOH A O 1 HETATM 4727 O O . HOH H 5 . ? 27.882 56.006 27.549 1.00 37.74 ? 1363 HOH A O 1 # loop_ _pdbx_poly_seq_scheme.asym_id _pdbx_poly_seq_scheme.entity_id _pdbx_poly_seq_scheme.seq_id _pdbx_poly_seq_scheme.mon_id _pdbx_poly_seq_scheme.ndb_seq_num _pdbx_poly_seq_scheme.pdb_seq_num _pdbx_poly_seq_scheme.auth_seq_num _pdbx_poly_seq_scheme.pdb_mon_id _pdbx_poly_seq_scheme.auth_mon_id _pdbx_poly_seq_scheme.pdb_strand_id _pdbx_poly_seq_scheme.pdb_ins_code _pdbx_poly_seq_scheme.hetero A 1 1 GLN 1 1 ? ? ? A . n A 1 2 GLN 2 2 2 GLN GLN A . n A 1 3 ILE 3 3 3 ILE ILE A . n A 1 4 GLU 4 4 4 GLU GLU A . n A 1 5 GLN 5 5 5 GLN GLN A . n A 1 6 PRO 6 6 6 PRO PRO A . n A 1 7 TYR 7 7 7 TYR TYR A . n A 1 8 ARG 8 8 8 ARG ARG A . n A 1 9 THR 9 9 9 THR THR A . n A 1 10 GLY 10 10 10 GLY GLY A . n A 1 11 TYR 11 11 11 TYR TYR A . n A 1 12 HIS 12 12 12 HIS HIS A . n A 1 13 PHE 13 13 13 PHE PHE A . n A 1 14 GLN 14 14 14 GLN GLN A . n A 1 15 PRO 15 15 15 PRO PRO A . n A 1 16 PRO 16 16 16 PRO PRO A . n A 1 17 SER 17 17 17 SER SER A . n A 1 18 ASN 18 18 18 ASN ASN A . n A 1 19 TRP 19 19 19 TRP TRP A . n A 1 20 MET 20 20 20 MET MET A . n A 1 21 ASN 21 21 21 ASN ASN A . n A 1 22 ASP 22 22 22 ASP ASP A . n A 1 23 PRO 23 23 23 PRO PRO A . n A 1 24 ASN 24 24 24 ASN ASN A . n A 1 25 GLY 25 25 25 GLY GLY A . n A 1 26 PRO 26 26 26 PRO PRO A . n A 1 27 MET 27 27 27 MET MET A . n A 1 28 LEU 28 28 28 LEU LEU A . n A 1 29 TYR 29 29 29 TYR TYR A . n A 1 30 GLN 30 30 30 GLN GLN A . n A 1 31 GLY 31 31 31 GLY GLY A . n A 1 32 VAL 32 32 32 VAL VAL A . n A 1 33 TYR 33 33 33 TYR TYR A . n A 1 34 HIS 34 34 34 HIS HIS A . n A 1 35 PHE 35 35 35 PHE PHE A . n A 1 36 PHE 36 36 36 PHE PHE A . n A 1 37 TYR 37 37 37 TYR TYR A . n A 1 38 GLN 38 38 38 GLN GLN A . n A 1 39 TYR 39 39 39 TYR TYR A . n A 1 40 ASN 40 40 40 ASN ASN A . n A 1 41 PRO 41 41 41 PRO PRO A . n A 1 42 TYR 42 42 42 TYR TYR A . n A 1 43 ALA 43 43 43 ALA ALA A . n A 1 44 ALA 44 44 44 ALA ALA A . n A 1 45 THR 45 45 45 THR THR A . n A 1 46 PHE 46 46 46 PHE PHE A . n A 1 47 GLY 47 47 47 GLY GLY A . n A 1 48 ASP 48 48 48 ASP ASP A . n A 1 49 VAL 49 49 49 VAL VAL A . n A 1 50 ILE 50 50 50 ILE ILE A . n A 1 51 ILE 51 51 51 ILE ILE A . n A 1 52 TRP 52 52 52 TRP TRP A . n A 1 53 GLY 53 53 53 GLY GLY A . n A 1 54 HIS 54 54 54 HIS HIS A . n A 1 55 ALA 55 55 55 ALA ALA A . n A 1 56 VAL 56 56 56 VAL VAL A . n A 1 57 SER 57 57 57 SER SER A . n A 1 58 TYR 58 58 58 TYR TYR A . n A 1 59 ASP 59 59 59 ASP ASP A . n A 1 60 LEU 60 60 60 LEU LEU A . n A 1 61 VAL 61 61 61 VAL VAL A . n A 1 62 ASN 62 62 62 ASN ASN A . n A 1 63 TRP 63 63 63 TRP TRP A . n A 1 64 ILE 64 64 64 ILE ILE A . n A 1 65 HIS 65 65 65 HIS HIS A . n A 1 66 LEU 66 66 66 LEU LEU A . n A 1 67 ASP 67 67 67 ASP ASP A . n A 1 68 PRO 68 68 68 PRO PRO A . n A 1 69 ALA 69 69 69 ALA ALA A . n A 1 70 ILE 70 70 70 ILE ILE A . n A 1 71 TYR 71 71 71 TYR TYR A . n A 1 72 PRO 72 72 72 PRO PRO A . n A 1 73 THR 73 73 73 THR THR A . n A 1 74 GLN 74 74 74 GLN GLN A . n A 1 75 GLU 75 75 75 GLU GLU A . n A 1 76 ALA 76 76 76 ALA ALA A . n A 1 77 ASP 77 77 77 ASP ASP A . n A 1 78 SER 78 78 78 SER SER A . n A 1 79 LYS 79 79 79 LYS LYS A . n A 1 80 SER 80 80 80 SER SER A . n A 1 81 CYS 81 81 81 CYS CYS A . n A 1 82 TRP 82 82 82 TRP TRP A . n A 1 83 SER 83 83 83 SER SER A . n A 1 84 GLY 84 84 84 GLY GLY A . n A 1 85 SER 85 85 85 SER SER A . n A 1 86 ALA 86 86 86 ALA ALA A . n A 1 87 THR 87 87 87 THR THR A . n A 1 88 ILE 88 88 88 ILE ILE A . n A 1 89 LEU 89 89 89 LEU LEU A . n A 1 90 PRO 90 90 90 PRO PRO A . n A 1 91 GLY 91 91 91 GLY GLY A . n A 1 92 ASN 92 92 92 ASN ASN A . n A 1 93 ILE 93 93 93 ILE ILE A . n A 1 94 PRO 94 94 94 PRO PRO A . n A 1 95 ALA 95 95 95 ALA ALA A . n A 1 96 MET 96 96 96 MET MET A . n A 1 97 LEU 97 97 97 LEU LEU A . n A 1 98 TYR 98 98 98 TYR TYR A . n A 1 99 THR 99 99 99 THR THR A . n A 1 100 GLY 100 100 100 GLY GLY A . n A 1 101 SER 101 101 101 SER SER A . n A 1 102 ASP 102 102 102 ASP ASP A . n A 1 103 SER 103 103 103 SER SER A . n A 1 104 LYS 104 104 104 LYS LYS A . n A 1 105 SER 105 105 105 SER SER A . n A 1 106 ARG 106 106 106 ARG ARG A . n A 1 107 GLN 107 107 107 GLN GLN A . n A 1 108 VAL 108 108 108 VAL VAL A . n A 1 109 GLN 109 109 109 GLN GLN A . n A 1 110 ASP 110 110 110 ASP ASP A . n A 1 111 LEU 111 111 111 LEU LEU A . n A 1 112 ALA 112 112 112 ALA ALA A . n A 1 113 TRP 113 113 113 TRP TRP A . n A 1 114 PRO 114 114 114 PRO PRO A . n A 1 115 LYS 115 115 115 LYS LYS A . n A 1 116 ASN 116 116 116 ASN ASN A . n A 1 117 LEU 117 117 117 LEU LEU A . n A 1 118 SER 118 118 118 SER SER A . n A 1 119 ASP 119 119 119 ASP ASP A . n A 1 120 PRO 120 120 120 PRO PRO A . n A 1 121 PHE 121 121 121 PHE PHE A . n A 1 122 LEU 122 122 122 LEU LEU A . n A 1 123 ARG 123 123 123 ARG ARG A . n A 1 124 GLU 124 124 124 GLU GLU A . n A 1 125 TRP 125 125 125 TRP TRP A . n A 1 126 VAL 126 126 126 VAL VAL A . n A 1 127 LYS 127 127 127 LYS LYS A . n A 1 128 HIS 128 128 128 HIS HIS A . n A 1 129 PRO 129 129 129 PRO PRO A . n A 1 130 LYS 130 130 130 LYS LYS A . n A 1 131 ASN 131 131 131 ASN ASN A . n A 1 132 PRO 132 132 132 PRO PRO A . n A 1 133 LEU 133 133 133 LEU LEU A . n A 1 134 ILE 134 134 134 ILE ILE A . n A 1 135 THR 135 135 135 THR THR A . n A 1 136 PRO 136 136 136 PRO PRO A . n A 1 137 PRO 137 137 137 PRO PRO A . n A 1 138 GLU 138 138 138 GLU GLU A . n A 1 139 GLY 139 139 139 GLY GLY A . n A 1 140 VAL 140 140 140 VAL VAL A . n A 1 141 LYS 141 141 141 LYS LYS A . n A 1 142 ASP 142 142 142 ASP ASP A . n A 1 143 ASP 143 143 143 ASP ASP A . n A 1 144 CYS 144 144 144 CYS CYS A . n A 1 145 PHE 145 145 145 PHE PHE A . n A 1 146 ARG 146 146 146 ARG ARG A . n A 1 147 ASP 147 147 147 ASP ASP A . n A 1 148 PRO 148 148 148 PRO PRO A . n A 1 149 SER 149 149 149 SER SER A . n A 1 150 THR 150 150 150 THR THR A . n A 1 151 ALA 151 151 151 ALA ALA A . n A 1 152 TRP 152 152 152 TRP TRP A . n A 1 153 LEU 153 153 153 LEU LEU A . n A 1 154 GLY 154 154 154 GLY GLY A . n A 1 155 PRO 155 155 155 PRO PRO A . n A 1 156 ASP 156 156 156 ASP ASP A . n A 1 157 GLY 157 157 157 GLY GLY A . n A 1 158 VAL 158 158 158 VAL VAL A . n A 1 159 TRP 159 159 159 TRP TRP A . n A 1 160 ARG 160 160 160 ARG ARG A . n A 1 161 ILE 161 161 161 ILE ILE A . n A 1 162 VAL 162 162 162 VAL VAL A . n A 1 163 VAL 163 163 163 VAL VAL A . n A 1 164 GLY 164 164 164 GLY GLY A . n A 1 165 GLY 165 165 165 GLY GLY A . n A 1 166 ASP 166 166 166 ASP ASP A . n A 1 167 ARG 167 167 167 ARG ARG A . n A 1 168 ASP 168 168 168 ASP ASP A . n A 1 169 ASN 169 169 169 ASN ASN A . n A 1 170 ASN 170 170 170 ASN ASN A . n A 1 171 GLY 171 171 171 GLY GLY A . n A 1 172 MET 172 172 172 MET MET A . n A 1 173 ALA 173 173 173 ALA ALA A . n A 1 174 PHE 174 174 174 PHE PHE A . n A 1 175 LEU 175 175 175 LEU LEU A . n A 1 176 TYR 176 176 176 TYR TYR A . n A 1 177 GLN 177 177 177 GLN GLN A . n A 1 178 SER 178 178 178 SER SER A . n A 1 179 THR 179 179 179 THR THR A . n A 1 180 ASP 180 180 180 ASP ASP A . n A 1 181 PHE 181 181 181 PHE PHE A . n A 1 182 VAL 182 182 182 VAL VAL A . n A 1 183 ASN 183 183 183 ASN ASN A . n A 1 184 TRP 184 184 184 TRP TRP A . n A 1 185 LYS 185 185 185 LYS LYS A . n A 1 186 ARG 186 186 186 ARG ARG A . n A 1 187 TYR 187 187 187 TYR TYR A . n A 1 188 ASP 188 188 188 ASP ASP A . n A 1 189 GLN 189 189 189 GLN GLN A . n A 1 190 PRO 190 190 190 PRO PRO A . n A 1 191 LEU 191 191 191 LEU LEU A . n A 1 192 SER 192 192 192 SER SER A . n A 1 193 SER 193 193 193 SER SER A . n A 1 194 ALA 194 194 194 ALA ALA A . n A 1 195 ASP 195 195 195 ASP ASP A . n A 1 196 ALA 196 196 196 ALA ALA A . n A 1 197 THR 197 197 197 THR THR A . n A 1 198 GLY 198 198 198 GLY GLY A . n A 1 199 THR 199 199 199 THR THR A . n A 1 200 TRP 200 200 200 TRP TRP A . n A 1 201 GLU 201 201 201 GLU GLU A . n A 1 202 CYS 202 202 202 CYS CYS A . n A 1 203 PRO 203 203 203 PRO PRO A . n A 1 204 ASP 204 204 204 ASP ASP A . n A 1 205 PHE 205 205 205 PHE PHE A . n A 1 206 TYR 206 206 206 TYR TYR A . n A 1 207 PRO 207 207 207 PRO PRO A . n A 1 208 VAL 208 208 208 VAL VAL A . n A 1 209 PRO 209 209 209 PRO PRO A . n A 1 210 LEU 210 210 210 LEU LEU A . n A 1 211 ASN 211 211 211 ASN ASN A . n A 1 212 SER 212 212 212 SER SER A . n A 1 213 THR 213 213 213 THR THR A . n A 1 214 ASN 214 214 214 ASN ASN A . n A 1 215 GLY 215 215 215 GLY GLY A . n A 1 216 LEU 216 216 216 LEU LEU A . n A 1 217 ASP 217 217 217 ASP ASP A . n A 1 218 THR 218 218 218 THR THR A . n A 1 219 SER 219 219 219 SER SER A . n A 1 220 VAL 220 220 220 VAL VAL A . n A 1 221 TYR 221 221 221 TYR TYR A . n A 1 222 GLY 222 222 222 GLY GLY A . n A 1 223 GLY 223 223 223 GLY GLY A . n A 1 224 SER 224 224 224 SER SER A . n A 1 225 VAL 225 225 225 VAL VAL A . n A 1 226 ARG 226 226 226 ARG ARG A . n A 1 227 HIS 227 227 227 HIS HIS A . n A 1 228 VAL 228 228 228 VAL VAL A . n A 1 229 MET 229 229 229 MET MET A . n A 1 230 LYS 230 230 230 LYS LYS A . n A 1 231 ALA 231 231 231 ALA ALA A . n A 1 232 GLY 232 232 232 GLY GLY A . n A 1 233 PHE 233 233 233 PHE PHE A . n A 1 234 GLU 234 234 234 GLU GLU A . n A 1 235 GLY 235 235 235 GLY GLY A . n A 1 236 HIS 236 236 236 HIS HIS A . n A 1 237 ASP 237 237 237 ASP ASP A . n A 1 238 TRP 238 238 238 TRP TRP A . n A 1 239 TYR 239 239 239 TYR TYR A . n A 1 240 THR 240 240 240 THR THR A . n A 1 241 ILE 241 241 241 ILE ILE A . n A 1 242 GLY 242 242 242 GLY GLY A . n A 1 243 THR 243 243 243 THR THR A . n A 1 244 TYR 244 244 244 TYR TYR A . n A 1 245 SER 245 245 245 SER SER A . n A 1 246 PRO 246 246 246 PRO PRO A . n A 1 247 ASP 247 247 247 ASP ASP A . n A 1 248 ARG 248 248 248 ARG ARG A . n A 1 249 GLU 249 249 249 GLU GLU A . n A 1 250 ASN 250 250 250 ASN ASN A . n A 1 251 PHE 251 251 251 PHE PHE A . n A 1 252 LEU 252 252 252 LEU LEU A . n A 1 253 PRO 253 253 253 PRO PRO A . n A 1 254 GLN 254 254 254 GLN GLN A . n A 1 255 ASN 255 255 255 ASN ASN A . n A 1 256 GLY 256 256 256 GLY GLY A . n A 1 257 LEU 257 257 257 LEU LEU A . n A 1 258 SER 258 258 258 SER SER A . n A 1 259 LEU 259 259 259 LEU LEU A . n A 1 260 THR 260 260 260 THR THR A . n A 1 261 GLY 261 261 261 GLY GLY A . n A 1 262 SER 262 262 262 SER SER A . n A 1 263 THR 263 263 263 THR THR A . n A 1 264 LEU 264 264 264 LEU LEU A . n A 1 265 ASP 265 265 265 ASP ASP A . n A 1 266 LEU 266 266 266 LEU LEU A . n A 1 267 ARG 267 267 267 ARG ARG A . n A 1 268 TYR 268 268 268 TYR TYR A . n A 1 269 ASP 269 269 269 ASP ASP A . n A 1 270 TYR 270 270 270 TYR TYR A . n A 1 271 GLY 271 271 271 GLY GLY A . n A 1 272 GLN 272 272 272 GLN GLN A . n A 1 273 PHE 273 273 273 PHE PHE A . n A 1 274 TYR 274 274 274 TYR TYR A . n A 1 275 ALA 275 275 275 ALA ALA A . n A 1 276 SER 276 276 276 SER SER A . n A 1 277 LYS 277 277 277 LYS LYS A . n A 1 278 SER 278 278 278 SER SER A . n A 1 279 PHE 279 279 279 PHE PHE A . n A 1 280 PHE 280 280 280 PHE PHE A . n A 1 281 ASP 281 281 281 ASP ASP A . n A 1 282 ASP 282 282 282 ASP ASP A . n A 1 283 ALA 283 283 283 ALA ALA A . n A 1 284 LYS 284 284 284 LYS LYS A . n A 1 285 ASN 285 285 285 ASN ASN A . n A 1 286 ARG 286 286 286 ARG ARG A . n A 1 287 ARG 287 287 287 ARG ARG A . n A 1 288 VAL 288 288 288 VAL VAL A . n A 1 289 LEU 289 289 289 LEU LEU A . n A 1 290 TRP 290 290 290 TRP TRP A . n A 1 291 ALA 291 291 291 ALA ALA A . n A 1 292 TRP 292 292 292 TRP TRP A . n A 1 293 VAL 293 293 293 VAL VAL A . n A 1 294 PRO 294 294 294 PRO PRO A . n A 1 295 GLU 295 295 295 GLU GLU A . n A 1 296 THR 296 296 296 THR THR A . n A 1 297 ASP 297 297 297 ASP ASP A . n A 1 298 SER 298 298 298 SER SER A . n A 1 299 GLN 299 299 299 GLN GLN A . n A 1 300 ALA 300 300 300 ALA ALA A . n A 1 301 ASP 301 301 301 ASP ASP A . n A 1 302 ASP 302 302 302 ASP ASP A . n A 1 303 ILE 303 303 303 ILE ILE A . n A 1 304 GLU 304 304 304 GLU GLU A . n A 1 305 LYS 305 305 305 LYS LYS A . n A 1 306 GLY 306 306 306 GLY GLY A . n A 1 307 TRP 307 307 307 TRP TRP A . n A 1 308 ALA 308 308 308 ALA ALA A . n A 1 309 GLY 309 309 309 GLY GLY A . n A 1 310 LEU 310 310 310 LEU LEU A . n A 1 311 GLN 311 311 311 GLN GLN A . n A 1 312 SER 312 312 312 SER SER A . n A 1 313 PHE 313 313 313 PHE PHE A . n A 1 314 PRO 314 314 314 PRO PRO A . n A 1 315 ARG 315 315 315 ARG ARG A . n A 1 316 ALA 316 316 316 ALA ALA A . n A 1 317 LEU 317 317 317 LEU LEU A . n A 1 318 TRP 318 318 318 TRP TRP A . n A 1 319 ILE 319 319 319 ILE ILE A . n A 1 320 ASP 320 320 320 ASP ASP A . n A 1 321 ARG 321 321 321 ARG ARG A . n A 1 322 ASN 322 322 322 ASN ASN A . n A 1 323 GLY 323 323 323 GLY GLY A . n A 1 324 LYS 324 324 324 LYS LYS A . n A 1 325 GLN 325 325 325 GLN GLN A . n A 1 326 LEU 326 326 326 LEU LEU A . n A 1 327 ILE 327 327 327 ILE ILE A . n A 1 328 GLN 328 328 328 GLN GLN A . n A 1 329 TRP 329 329 329 TRP TRP A . n A 1 330 PRO 330 330 330 PRO PRO A . n A 1 331 VAL 331 331 331 VAL VAL A . n A 1 332 GLU 332 332 332 GLU GLU A . n A 1 333 GLU 333 333 333 GLU GLU A . n A 1 334 ILE 334 334 334 ILE ILE A . n A 1 335 GLU 335 335 335 GLU GLU A . n A 1 336 GLU 336 336 336 GLU GLU A . n A 1 337 LEU 337 337 337 LEU LEU A . n A 1 338 ARG 338 338 338 ARG ARG A . n A 1 339 GLN 339 339 339 GLN GLN A . n A 1 340 ASN 340 340 340 ASN ASN A . n A 1 341 GLN 341 341 341 GLN GLN A . n A 1 342 VAL 342 342 342 VAL VAL A . n A 1 343 ASN 343 343 343 ASN ASN A . n A 1 344 LEU 344 344 344 LEU LEU A . n A 1 345 GLN 345 345 345 GLN GLN A . n A 1 346 ASN 346 346 346 ASN ASN A . n A 1 347 LYS 347 347 347 LYS LYS A . n A 1 348 ASN 348 348 348 ASN ASN A . n A 1 349 LEU 349 349 349 LEU LEU A . n A 1 350 LYS 350 350 350 LYS LYS A . n A 1 351 PRO 351 351 351 PRO PRO A . n A 1 352 GLY 352 352 352 GLY GLY A . n A 1 353 SER 353 353 353 SER SER A . n A 1 354 VAL 354 354 354 VAL VAL A . n A 1 355 LEU 355 355 355 LEU LEU A . n A 1 356 GLU 356 356 356 GLU GLU A . n A 1 357 ILE 357 357 357 ILE ILE A . n A 1 358 HIS 358 358 358 HIS HIS A . n A 1 359 GLY 359 359 359 GLY GLY A . n A 1 360 ILE 360 360 360 ILE ILE A . n A 1 361 ALA 361 361 361 ALA ALA A . n A 1 362 ALA 362 362 362 ALA ALA A . n A 1 363 SER 363 363 363 SER SER A . n A 1 364 GLN 364 364 364 GLN GLN A . n A 1 365 ALA 365 365 365 ALA ALA A . n A 1 366 ASP 366 366 366 ASP ASP A . n A 1 367 VAL 367 367 367 VAL VAL A . n A 1 368 THR 368 368 368 THR THR A . n A 1 369 ILE 369 369 369 ILE ILE A . n A 1 370 SER 370 370 370 SER SER A . n A 1 371 PHE 371 371 371 PHE PHE A . n A 1 372 LYS 372 372 372 LYS LYS A . n A 1 373 LEU 373 373 373 LEU LEU A . n A 1 374 GLU 374 374 374 GLU GLU A . n A 1 375 GLY 375 375 375 GLY GLY A . n A 1 376 LEU 376 376 376 LEU LEU A . n A 1 377 LYS 377 377 377 LYS LYS A . n A 1 378 GLU 378 378 378 GLU GLU A . n A 1 379 ALA 379 379 379 ALA ALA A . n A 1 380 GLU 380 380 380 GLU GLU A . n A 1 381 VAL 381 381 381 VAL VAL A . n A 1 382 LEU 382 382 382 LEU LEU A . n A 1 383 ASP 383 383 383 ASP ASP A . n A 1 384 THR 384 384 384 THR THR A . n A 1 385 THR 385 385 385 THR THR A . n A 1 386 LEU 386 386 386 LEU LEU A . n A 1 387 VAL 387 387 387 VAL VAL A . n A 1 388 ASP 388 388 388 ASP ASP A . n A 1 389 PRO 389 389 389 PRO PRO A . n A 1 390 GLN 390 390 390 GLN GLN A . n A 1 391 ALA 391 391 391 ALA ALA A . n A 1 392 LEU 392 392 392 LEU LEU A . n A 1 393 CYS 393 393 393 CYS CYS A . n A 1 394 ASN 394 394 394 ASN ASN A . n A 1 395 GLU 395 395 395 GLU GLU A . n A 1 396 ARG 396 396 396 ARG ARG A . n A 1 397 GLY 397 397 397 GLY GLY A . n A 1 398 ALA 398 398 398 ALA ALA A . n A 1 399 SER 399 399 399 SER SER A . n A 1 400 SER 400 400 400 SER SER A . n A 1 401 ARG 401 401 401 ARG ARG A . n A 1 402 GLY 402 402 402 GLY GLY A . n A 1 403 ALA 403 403 403 ALA ALA A . n A 1 404 LEU 404 404 404 LEU LEU A . n A 1 405 GLY 405 405 405 GLY GLY A . n A 1 406 PRO 406 406 406 PRO PRO A . n A 1 407 PHE 407 407 407 PHE PHE A . n A 1 408 GLY 408 408 408 GLY GLY A . n A 1 409 LEU 409 409 409 LEU LEU A . n A 1 410 LEU 410 410 410 LEU LEU A . n A 1 411 ALA 411 411 411 ALA ALA A . n A 1 412 MET 412 412 412 MET MET A . n A 1 413 ALA 413 413 413 ALA ALA A . n A 1 414 SER 414 414 414 SER SER A . n A 1 415 LYS 415 415 415 LYS LYS A . n A 1 416 ASP 416 416 416 ASP ASP A . n A 1 417 LEU 417 417 417 LEU LEU A . n A 1 418 LYS 418 418 418 LYS LYS A . n A 1 419 GLU 419 419 419 GLU GLU A . n A 1 420 GLN 420 420 420 GLN GLN A . n A 1 421 SER 421 421 421 SER SER A . n A 1 422 ALA 422 422 422 ALA ALA A . n A 1 423 ILE 423 423 423 ILE ILE A . n A 1 424 PHE 424 424 424 PHE PHE A . n A 1 425 PHE 425 425 425 PHE PHE A . n A 1 426 ARG 426 426 426 ARG ARG A . n A 1 427 VAL 427 427 427 VAL VAL A . n A 1 428 PHE 428 428 428 PHE PHE A . n A 1 429 GLN 429 429 429 GLN GLN A . n A 1 430 ASN 430 430 430 ASN ASN A . n A 1 431 GLN 431 431 431 GLN GLN A . n A 1 432 LEU 432 432 432 LEU LEU A . n A 1 433 GLY 433 433 433 GLY GLY A . n A 1 434 ARG 434 434 434 ARG ARG A . n A 1 435 TYR 435 435 435 TYR TYR A . n A 1 436 SER 436 436 436 SER SER A . n A 1 437 VAL 437 437 437 VAL VAL A . n A 1 438 LEU 438 438 438 LEU LEU A . n A 1 439 MET 439 439 439 MET MET A . n A 1 440 CYS 440 440 440 CYS CYS A . n A 1 441 SER 441 441 441 SER SER A . n A 1 442 ASP 442 442 442 ASP ASP A . n A 1 443 LEU 443 443 443 LEU LEU A . n A 1 444 SER 444 444 444 SER SER A . n A 1 445 ARG 445 445 445 ARG ARG A . n A 1 446 SER 446 446 446 SER SER A . n A 1 447 THR 447 447 447 THR THR A . n A 1 448 VAL 448 448 448 VAL VAL A . n A 1 449 ARG 449 449 449 ARG ARG A . n A 1 450 SER 450 450 450 SER SER A . n A 1 451 ASN 451 451 451 ASN ASN A . n A 1 452 ILE 452 452 452 ILE ILE A . n A 1 453 ASP 453 453 453 ASP ASP A . n A 1 454 THR 454 454 454 THR THR A . n A 1 455 THR 455 455 455 THR THR A . n A 1 456 SER 456 456 456 SER SER A . n A 1 457 TYR 457 457 457 TYR TYR A . n A 1 458 GLY 458 458 458 GLY GLY A . n A 1 459 ALA 459 459 459 ALA ALA A . n A 1 460 PHE 460 460 460 PHE PHE A . n A 1 461 VAL 461 461 461 VAL VAL A . n A 1 462 ASP 462 462 462 ASP ASP A . n A 1 463 ILE 463 463 463 ILE ILE A . n A 1 464 ASP 464 464 464 ASP ASP A . n A 1 465 PRO 465 465 465 PRO PRO A . n A 1 466 ARG 466 466 466 ARG ARG A . n A 1 467 SER 467 467 467 SER SER A . n A 1 468 GLU 468 468 468 GLU GLU A . n A 1 469 GLU 469 469 469 GLU GLU A . n A 1 470 ILE 470 470 470 ILE ILE A . n A 1 471 SER 471 471 471 SER SER A . n A 1 472 LEU 472 472 472 LEU LEU A . n A 1 473 ARG 473 473 473 ARG ARG A . n A 1 474 ASN 474 474 474 ASN ASN A . n A 1 475 LEU 475 475 475 LEU LEU A . n A 1 476 ILE 476 476 476 ILE ILE A . n A 1 477 ASP 477 477 477 ASP ASP A . n A 1 478 HIS 478 478 478 HIS HIS A . n A 1 479 SER 479 479 479 SER SER A . n A 1 480 ILE 480 480 480 ILE ILE A . n A 1 481 ILE 481 481 481 ILE ILE A . n A 1 482 GLU 482 482 482 GLU GLU A . n A 1 483 SER 483 483 483 SER SER A . n A 1 484 PHE 484 484 484 PHE PHE A . n A 1 485 GLY 485 485 485 GLY GLY A . n A 1 486 ALA 486 486 486 ALA ALA A . n A 1 487 GLY 487 487 487 GLY GLY A . n A 1 488 GLY 488 488 488 GLY GLY A . n A 1 489 LYS 489 489 489 LYS LYS A . n A 1 490 THR 490 490 490 THR THR A . n A 1 491 CYS 491 491 491 CYS CYS A . n A 1 492 ILE 492 492 492 ILE ILE A . n A 1 493 THR 493 493 493 THR THR A . n A 1 494 SER 494 494 494 SER SER A . n A 1 495 ARG 495 495 495 ARG ARG A . n A 1 496 ILE 496 496 496 ILE ILE A . n A 1 497 TYR 497 497 497 TYR TYR A . n A 1 498 PRO 498 498 498 PRO PRO A . n A 1 499 LYS 499 499 499 LYS LYS A . n A 1 500 PHE 500 500 500 PHE PHE A . n A 1 501 VAL 501 501 501 VAL VAL A . n A 1 502 ASN 502 502 502 ASN ASN A . n A 1 503 ASN 503 503 503 ASN ASN A . n A 1 504 GLU 504 504 504 GLU GLU A . n A 1 505 GLU 505 505 505 GLU GLU A . n A 1 506 ALA 506 506 506 ALA ALA A . n A 1 507 HIS 507 507 507 HIS HIS A . n A 1 508 LEU 508 508 508 LEU LEU A . n A 1 509 PHE 509 509 509 PHE PHE A . n A 1 510 VAL 510 510 510 VAL VAL A . n A 1 511 PHE 511 511 511 PHE PHE A . n A 1 512 ASN 512 512 512 ASN ASN A . n A 1 513 ASN 513 513 513 ASN ASN A . n A 1 514 GLY 514 514 514 GLY GLY A . n A 1 515 THR 515 515 515 THR THR A . n A 1 516 GLN 516 516 516 GLN GLN A . n A 1 517 ASN 517 517 517 ASN ASN A . n A 1 518 VAL 518 518 518 VAL VAL A . n A 1 519 LYS 519 519 519 LYS LYS A . n A 1 520 ILE 520 520 520 ILE ILE A . n A 1 521 SER 521 521 521 SER SER A . n A 1 522 GLU 522 522 522 GLU GLU A . n A 1 523 MET 523 523 523 MET MET A . n A 1 524 SER 524 524 524 SER SER A . n A 1 525 ALA 525 525 525 ALA ALA A . n A 1 526 TRP 526 526 526 TRP TRP A . n A 1 527 SER 527 527 527 SER SER A . n A 1 528 MET 528 528 528 MET MET A . n A 1 529 LYS 529 529 529 LYS LYS A . n A 1 530 ASN 530 530 530 ASN ASN A . n A 1 531 ALA 531 531 531 ALA ALA A . n A 1 532 LYS 532 532 532 LYS LYS A . n A 1 533 PHE 533 533 533 PHE PHE A . n A 1 534 VAL 534 534 534 VAL VAL A . n A 1 535 VAL 535 535 535 VAL VAL A . n A 1 536 ASP 536 536 536 ASP ASP A . n A 1 537 GLN 537 537 537 GLN GLN A . n A 1 538 SER 538 538 538 SER SER A . n A 1 539 VAL 539 539 ? ? ? A . n A 1 540 LYS 540 540 ? ? ? A . n A 1 541 SER 541 541 ? ? ? A . n A 1 542 ALA 542 542 ? ? ? A . n A 1 543 ALA 543 543 ? ? ? A . n # loop_ _pdbx_nonpoly_scheme.asym_id _pdbx_nonpoly_scheme.entity_id _pdbx_nonpoly_scheme.mon_id _pdbx_nonpoly_scheme.ndb_seq_num _pdbx_nonpoly_scheme.pdb_seq_num _pdbx_nonpoly_scheme.auth_seq_num _pdbx_nonpoly_scheme.pdb_mon_id _pdbx_nonpoly_scheme.auth_mon_id _pdbx_nonpoly_scheme.pdb_strand_id _pdbx_nonpoly_scheme.pdb_ins_code B 2 NAG 1 650 650 NAG NAG A . C 2 NAG 2 660 660 NAG NAG A . D 3 MAN 3 670 670 MAN MAN A . E 2 NAG 1 680 680 NAG NAG A . F 2 NAG 2 690 690 NAG NAG A . G 4 SUC 1 800 800 SUC SUC A . H 5 HOH 1 1001 1001 HOH TIP A . H 5 HOH 2 1002 1002 HOH TIP A . H 5 HOH 3 1003 1003 HOH TIP A . H 5 HOH 4 1004 1004 HOH TIP A . H 5 HOH 5 1005 1005 HOH TIP A . H 5 HOH 6 1006 1006 HOH TIP A . H 5 HOH 7 1007 1007 HOH TIP A . H 5 HOH 8 1008 1008 HOH TIP A . H 5 HOH 9 1009 1009 HOH TIP A . H 5 HOH 10 1010 1010 HOH TIP A . H 5 HOH 11 1011 1011 HOH TIP A . H 5 HOH 12 1012 1012 HOH TIP A . H 5 HOH 13 1013 1013 HOH TIP A . H 5 HOH 14 1014 1014 HOH TIP A . H 5 HOH 15 1015 1015 HOH TIP A . H 5 HOH 16 1016 1016 HOH TIP A . H 5 HOH 17 1017 1017 HOH TIP A . H 5 HOH 18 1018 1018 HOH TIP A . H 5 HOH 19 1019 1019 HOH TIP A . H 5 HOH 20 1020 1020 HOH TIP A . H 5 HOH 21 1021 1021 HOH TIP A . H 5 HOH 22 1022 1022 HOH TIP A . H 5 HOH 23 1023 1023 HOH TIP A . H 5 HOH 24 1024 1024 HOH TIP A . H 5 HOH 25 1025 1025 HOH TIP A . H 5 HOH 26 1026 1026 HOH TIP A . H 5 HOH 27 1027 1027 HOH TIP A . H 5 HOH 28 1028 1028 HOH TIP A . H 5 HOH 29 1029 1029 HOH TIP A . H 5 HOH 30 1030 1030 HOH TIP A . H 5 HOH 31 1031 1031 HOH TIP A . H 5 HOH 32 1032 1032 HOH TIP A . H 5 HOH 33 1033 1033 HOH TIP A . H 5 HOH 34 1034 1034 HOH TIP A . H 5 HOH 35 1035 1035 HOH TIP A . H 5 HOH 36 1036 1036 HOH TIP A . H 5 HOH 37 1037 1037 HOH TIP A . H 5 HOH 38 1038 1038 HOH TIP A . H 5 HOH 39 1039 1039 HOH TIP A . H 5 HOH 40 1040 1040 HOH TIP A . H 5 HOH 41 1041 1041 HOH TIP A . H 5 HOH 42 1042 1042 HOH TIP A . H 5 HOH 43 1043 1043 HOH TIP A . H 5 HOH 44 1044 1044 HOH TIP A . H 5 HOH 45 1045 1045 HOH TIP A . H 5 HOH 46 1046 1046 HOH TIP A . H 5 HOH 47 1047 1047 HOH TIP A . H 5 HOH 48 1048 1048 HOH TIP A . H 5 HOH 49 1049 1049 HOH TIP A . H 5 HOH 50 1050 1050 HOH TIP A . H 5 HOH 51 1051 1051 HOH TIP A . H 5 HOH 52 1052 1052 HOH TIP A . H 5 HOH 53 1053 1053 HOH TIP A . H 5 HOH 54 1054 1054 HOH TIP A . H 5 HOH 55 1055 1055 HOH TIP A . H 5 HOH 56 1056 1056 HOH TIP A . H 5 HOH 57 1057 1057 HOH TIP A . H 5 HOH 58 1058 1058 HOH TIP A . H 5 HOH 59 1059 1059 HOH TIP A . H 5 HOH 60 1060 1060 HOH TIP A . H 5 HOH 61 1061 1061 HOH TIP A . H 5 HOH 62 1062 1062 HOH TIP A . H 5 HOH 63 1063 1063 HOH TIP A . H 5 HOH 64 1064 1064 HOH TIP A . H 5 HOH 65 1065 1065 HOH TIP A . H 5 HOH 66 1066 1066 HOH TIP A . H 5 HOH 67 1067 1067 HOH TIP A . H 5 HOH 68 1068 1068 HOH TIP A . H 5 HOH 69 1069 1069 HOH TIP A . H 5 HOH 70 1070 1070 HOH TIP A . H 5 HOH 71 1071 1071 HOH TIP A . H 5 HOH 72 1072 1072 HOH TIP A . H 5 HOH 73 1073 1073 HOH TIP A . H 5 HOH 74 1074 1074 HOH TIP A . H 5 HOH 75 1075 1075 HOH TIP A . H 5 HOH 76 1076 1076 HOH TIP A . H 5 HOH 77 1077 1077 HOH TIP A . H 5 HOH 78 1078 1078 HOH TIP A . H 5 HOH 79 1079 1079 HOH TIP A . H 5 HOH 80 1080 1080 HOH TIP A . H 5 HOH 81 1081 1081 HOH TIP A . H 5 HOH 82 1082 1082 HOH TIP A . H 5 HOH 83 1083 1083 HOH TIP A . H 5 HOH 84 1084 1084 HOH TIP A . H 5 HOH 85 1085 1085 HOH TIP A . H 5 HOH 86 1086 1086 HOH TIP A . H 5 HOH 87 1087 1087 HOH TIP A . H 5 HOH 88 1088 1088 HOH TIP A . H 5 HOH 89 1089 1089 HOH TIP A . H 5 HOH 90 1090 1090 HOH TIP A . H 5 HOH 91 1091 1091 HOH TIP A . H 5 HOH 92 1092 1092 HOH TIP A . H 5 HOH 93 1093 1093 HOH TIP A . H 5 HOH 94 1094 1094 HOH TIP A . H 5 HOH 95 1095 1095 HOH TIP A . H 5 HOH 96 1096 1096 HOH TIP A . H 5 HOH 97 1097 1097 HOH TIP A . H 5 HOH 98 1098 1098 HOH TIP A . H 5 HOH 99 1099 1099 HOH TIP A . H 5 HOH 100 1100 1100 HOH TIP A . H 5 HOH 101 1101 1101 HOH TIP A . H 5 HOH 102 1102 1102 HOH TIP A . H 5 HOH 103 1103 1103 HOH TIP A . H 5 HOH 104 1104 1104 HOH TIP A . H 5 HOH 105 1105 1105 HOH TIP A . H 5 HOH 106 1106 1106 HOH TIP A . H 5 HOH 107 1107 1107 HOH TIP A . H 5 HOH 108 1108 1108 HOH TIP A . H 5 HOH 109 1109 1109 HOH TIP A . H 5 HOH 110 1110 1110 HOH TIP A . H 5 HOH 111 1111 1111 HOH TIP A . H 5 HOH 112 1112 1112 HOH TIP A . H 5 HOH 113 1113 1113 HOH TIP A . H 5 HOH 114 1114 1114 HOH TIP A . H 5 HOH 115 1115 1115 HOH TIP A . H 5 HOH 116 1116 1116 HOH TIP A . H 5 HOH 117 1117 1117 HOH TIP A . H 5 HOH 118 1118 1118 HOH TIP A . H 5 HOH 119 1119 1119 HOH TIP A . H 5 HOH 120 1120 1120 HOH TIP A . H 5 HOH 121 1121 1121 HOH TIP A . H 5 HOH 122 1122 1122 HOH TIP A . H 5 HOH 123 1123 1123 HOH TIP A . H 5 HOH 124 1124 1124 HOH TIP A . H 5 HOH 125 1125 1125 HOH TIP A . H 5 HOH 126 1126 1126 HOH TIP A . H 5 HOH 127 1127 1127 HOH TIP A . H 5 HOH 128 1128 1128 HOH TIP A . H 5 HOH 129 1129 1129 HOH TIP A . H 5 HOH 130 1130 1130 HOH TIP A . H 5 HOH 131 1131 1131 HOH TIP A . H 5 HOH 132 1132 1132 HOH TIP A . H 5 HOH 133 1133 1133 HOH TIP A . H 5 HOH 134 1134 1134 HOH TIP A . H 5 HOH 135 1135 1135 HOH TIP A . H 5 HOH 136 1136 1136 HOH TIP A . H 5 HOH 137 1137 1137 HOH TIP A . H 5 HOH 138 1138 1138 HOH TIP A . H 5 HOH 139 1139 1139 HOH TIP A . H 5 HOH 140 1140 1140 HOH TIP A . H 5 HOH 141 1141 1141 HOH TIP A . H 5 HOH 142 1142 1142 HOH TIP A . H 5 HOH 143 1143 1143 HOH TIP A . H 5 HOH 144 1144 1144 HOH TIP A . H 5 HOH 145 1145 1145 HOH TIP A . H 5 HOH 146 1146 1146 HOH TIP A . H 5 HOH 147 1147 1147 HOH TIP A . H 5 HOH 148 1148 1148 HOH TIP A . H 5 HOH 149 1149 1149 HOH TIP A . H 5 HOH 150 1150 1150 HOH TIP A . H 5 HOH 151 1151 1151 HOH TIP A . H 5 HOH 152 1152 1152 HOH TIP A . H 5 HOH 153 1153 1153 HOH TIP A . H 5 HOH 154 1154 1154 HOH TIP A . H 5 HOH 155 1155 1155 HOH TIP A . H 5 HOH 156 1156 1156 HOH TIP A . H 5 HOH 157 1157 1157 HOH TIP A . H 5 HOH 158 1158 1158 HOH TIP A . H 5 HOH 159 1159 1159 HOH TIP A . H 5 HOH 160 1160 1160 HOH TIP A . H 5 HOH 161 1161 1161 HOH TIP A . H 5 HOH 162 1162 1162 HOH TIP A . H 5 HOH 163 1163 1163 HOH TIP A . H 5 HOH 164 1164 1164 HOH TIP A . H 5 HOH 165 1165 1165 HOH TIP A . H 5 HOH 166 1166 1166 HOH TIP A . H 5 HOH 167 1167 1167 HOH TIP A . H 5 HOH 168 1168 1168 HOH TIP A . H 5 HOH 169 1169 1169 HOH TIP A . H 5 HOH 170 1170 1170 HOH TIP A . H 5 HOH 171 1171 1171 HOH TIP A . H 5 HOH 172 1172 1172 HOH TIP A . H 5 HOH 173 1173 1173 HOH TIP A . H 5 HOH 174 1174 1174 HOH TIP A . H 5 HOH 175 1175 1175 HOH TIP A . H 5 HOH 176 1176 1176 HOH TIP A . H 5 HOH 177 1177 1177 HOH TIP A . H 5 HOH 178 1178 1178 HOH TIP A . H 5 HOH 179 1179 1179 HOH TIP A . H 5 HOH 180 1180 1180 HOH TIP A . H 5 HOH 181 1181 1181 HOH TIP A . H 5 HOH 182 1182 1182 HOH TIP A . H 5 HOH 183 1183 1183 HOH TIP A . H 5 HOH 184 1184 1184 HOH TIP A . H 5 HOH 185 1185 1185 HOH TIP A . H 5 HOH 186 1186 1186 HOH TIP A . H 5 HOH 187 1187 1187 HOH TIP A . H 5 HOH 188 1188 1188 HOH TIP A . H 5 HOH 189 1189 1189 HOH TIP A . H 5 HOH 190 1190 1190 HOH TIP A . H 5 HOH 191 1191 1191 HOH TIP A . H 5 HOH 192 1192 1192 HOH TIP A . H 5 HOH 193 1193 1193 HOH TIP A . H 5 HOH 194 1194 1194 HOH TIP A . H 5 HOH 195 1195 1195 HOH TIP A . H 5 HOH 196 1196 1196 HOH TIP A . H 5 HOH 197 1197 1197 HOH TIP A . H 5 HOH 198 1198 1198 HOH TIP A . H 5 HOH 199 1199 1199 HOH TIP A . H 5 HOH 200 1200 1200 HOH TIP A . H 5 HOH 201 1201 1201 HOH TIP A . H 5 HOH 202 1202 1202 HOH TIP A . H 5 HOH 203 1203 1203 HOH TIP A . H 5 HOH 204 1204 1204 HOH TIP A . H 5 HOH 205 1205 1205 HOH TIP A . H 5 HOH 206 1206 1206 HOH TIP A . H 5 HOH 207 1207 1207 HOH TIP A . H 5 HOH 208 1208 1208 HOH TIP A . H 5 HOH 209 1209 1209 HOH TIP A . H 5 HOH 210 1210 1210 HOH TIP A . H 5 HOH 211 1211 1211 HOH TIP A . H 5 HOH 212 1212 1212 HOH TIP A . H 5 HOH 213 1213 1213 HOH TIP A . H 5 HOH 214 1214 1214 HOH TIP A . H 5 HOH 215 1215 1215 HOH TIP A . H 5 HOH 216 1216 1216 HOH TIP A . H 5 HOH 217 1217 1217 HOH TIP A . H 5 HOH 218 1218 1218 HOH TIP A . H 5 HOH 219 1219 1219 HOH TIP A . H 5 HOH 220 1220 1220 HOH TIP A . H 5 HOH 221 1221 1221 HOH TIP A . H 5 HOH 222 1222 1222 HOH TIP A . H 5 HOH 223 1223 1223 HOH TIP A . H 5 HOH 224 1224 1224 HOH TIP A . H 5 HOH 225 1225 1225 HOH TIP A . H 5 HOH 226 1226 1226 HOH TIP A . H 5 HOH 227 1227 1227 HOH TIP A . H 5 HOH 228 1228 1228 HOH TIP A . H 5 HOH 229 1229 1229 HOH TIP A . H 5 HOH 230 1230 1230 HOH TIP A . H 5 HOH 231 1231 1231 HOH TIP A . H 5 HOH 232 1232 1232 HOH TIP A . H 5 HOH 233 1233 1233 HOH TIP A . H 5 HOH 234 1234 1234 HOH TIP A . H 5 HOH 235 1235 1235 HOH TIP A . H 5 HOH 236 1236 1236 HOH TIP A . H 5 HOH 237 1237 1237 HOH TIP A . H 5 HOH 238 1238 1238 HOH TIP A . H 5 HOH 239 1239 1239 HOH TIP A . H 5 HOH 240 1240 1240 HOH TIP A . H 5 HOH 241 1241 1241 HOH TIP A . H 5 HOH 242 1242 1242 HOH TIP A . H 5 HOH 243 1243 1243 HOH TIP A . H 5 HOH 244 1244 1244 HOH TIP A . H 5 HOH 245 1245 1245 HOH TIP A . H 5 HOH 246 1246 1246 HOH TIP A . H 5 HOH 247 1247 1247 HOH TIP A . H 5 HOH 248 1248 1248 HOH TIP A . H 5 HOH 249 1249 1249 HOH TIP A . H 5 HOH 250 1250 1250 HOH TIP A . H 5 HOH 251 1251 1251 HOH TIP A . H 5 HOH 252 1252 1252 HOH TIP A . H 5 HOH 253 1253 1253 HOH TIP A . H 5 HOH 254 1254 1254 HOH TIP A . H 5 HOH 255 1255 1255 HOH TIP A . H 5 HOH 256 1256 1256 HOH TIP A . H 5 HOH 257 1257 1257 HOH TIP A . H 5 HOH 258 1258 1258 HOH TIP A . H 5 HOH 259 1259 1259 HOH TIP A . H 5 HOH 260 1260 1260 HOH TIP A . H 5 HOH 261 1261 1261 HOH TIP A . H 5 HOH 262 1262 1262 HOH TIP A . H 5 HOH 263 1263 1263 HOH TIP A . H 5 HOH 264 1264 1264 HOH TIP A . H 5 HOH 265 1265 1265 HOH TIP A . H 5 HOH 266 1266 1266 HOH TIP A . H 5 HOH 267 1267 1267 HOH TIP A . H 5 HOH 268 1268 1268 HOH TIP A . H 5 HOH 269 1269 1269 HOH TIP A . H 5 HOH 270 1270 1270 HOH TIP A . H 5 HOH 271 1271 1271 HOH TIP A . H 5 HOH 272 1272 1272 HOH TIP A . H 5 HOH 273 1273 1273 HOH TIP A . H 5 HOH 274 1274 1274 HOH TIP A . H 5 HOH 275 1275 1275 HOH TIP A . H 5 HOH 276 1276 1276 HOH TIP A . H 5 HOH 277 1277 1277 HOH TIP A . H 5 HOH 278 1278 1278 HOH TIP A . H 5 HOH 279 1279 1279 HOH TIP A . H 5 HOH 280 1280 1280 HOH TIP A . H 5 HOH 281 1281 1281 HOH TIP A . H 5 HOH 282 1282 1282 HOH TIP A . H 5 HOH 283 1283 1283 HOH TIP A . H 5 HOH 284 1284 1284 HOH TIP A . H 5 HOH 285 1285 1285 HOH TIP A . H 5 HOH 286 1286 1286 HOH TIP A . H 5 HOH 287 1287 1287 HOH TIP A . H 5 HOH 288 1288 1288 HOH TIP A . H 5 HOH 289 1289 1289 HOH TIP A . H 5 HOH 290 1290 1290 HOH TIP A . H 5 HOH 291 1291 1291 HOH TIP A . H 5 HOH 292 1292 1292 HOH TIP A . H 5 HOH 293 1293 1293 HOH TIP A . H 5 HOH 294 1294 1294 HOH TIP A . H 5 HOH 295 1295 1295 HOH TIP A . H 5 HOH 296 1296 1296 HOH TIP A . H 5 HOH 297 1297 1297 HOH TIP A . H 5 HOH 298 1298 1298 HOH TIP A . H 5 HOH 299 1299 1299 HOH TIP A . H 5 HOH 300 1300 1300 HOH TIP A . H 5 HOH 301 1301 1301 HOH TIP A . H 5 HOH 302 1302 1302 HOH TIP A . H 5 HOH 303 1303 1303 HOH TIP A . H 5 HOH 304 1304 1304 HOH TIP A . H 5 HOH 305 1305 1305 HOH TIP A . H 5 HOH 306 1306 1306 HOH TIP A . H 5 HOH 307 1307 1307 HOH TIP A . H 5 HOH 308 1308 1308 HOH TIP A . H 5 HOH 309 1309 1309 HOH TIP A . H 5 HOH 310 1310 1310 HOH TIP A . H 5 HOH 311 1311 1311 HOH TIP A . H 5 HOH 312 1312 1312 HOH TIP A . H 5 HOH 313 1313 1313 HOH TIP A . H 5 HOH 314 1314 1314 HOH TIP A . H 5 HOH 315 1315 1315 HOH TIP A . H 5 HOH 316 1316 1316 HOH TIP A . H 5 HOH 317 1317 1317 HOH TIP A . H 5 HOH 318 1318 1318 HOH TIP A . H 5 HOH 319 1319 1319 HOH TIP A . H 5 HOH 320 1320 1320 HOH TIP A . H 5 HOH 321 1321 1321 HOH TIP A . H 5 HOH 322 1322 1322 HOH TIP A . H 5 HOH 323 1323 1323 HOH TIP A . H 5 HOH 324 1324 1324 HOH TIP A . H 5 HOH 325 1325 1325 HOH TIP A . H 5 HOH 326 1326 1326 HOH TIP A . H 5 HOH 327 1327 1327 HOH TIP A . H 5 HOH 328 1328 1328 HOH TIP A . H 5 HOH 329 1329 1329 HOH TIP A . H 5 HOH 330 1330 1330 HOH TIP A . H 5 HOH 331 1331 1331 HOH TIP A . H 5 HOH 332 1332 1332 HOH TIP A . H 5 HOH 333 1333 1333 HOH TIP A . H 5 HOH 334 1334 1334 HOH TIP A . H 5 HOH 335 1335 1335 HOH TIP A . H 5 HOH 336 1336 1336 HOH TIP A . H 5 HOH 337 1337 1337 HOH TIP A . H 5 HOH 338 1338 1338 HOH TIP A . H 5 HOH 339 1339 1339 HOH TIP A . H 5 HOH 340 1340 1340 HOH TIP A . H 5 HOH 341 1341 1341 HOH TIP A . H 5 HOH 342 1342 1342 HOH TIP A . H 5 HOH 343 1343 1343 HOH TIP A . H 5 HOH 344 1344 1344 HOH TIP A . H 5 HOH 345 1345 1345 HOH TIP A . H 5 HOH 346 1346 1346 HOH TIP A . H 5 HOH 347 1347 1347 HOH TIP A . H 5 HOH 348 1348 1348 HOH TIP A . H 5 HOH 349 1349 1349 HOH TIP A . H 5 HOH 350 1350 1350 HOH TIP A . H 5 HOH 351 1351 1351 HOH TIP A . H 5 HOH 352 1352 1352 HOH TIP A . H 5 HOH 353 1353 1353 HOH TIP A . H 5 HOH 354 1354 1354 HOH TIP A . H 5 HOH 355 1355 1355 HOH TIP A . H 5 HOH 356 1356 1356 HOH TIP A . H 5 HOH 357 1357 1357 HOH TIP A . H 5 HOH 358 1358 1358 HOH TIP A . H 5 HOH 359 1359 1359 HOH TIP A . H 5 HOH 360 1360 1360 HOH TIP A . H 5 HOH 361 1361 1361 HOH TIP A . H 5 HOH 362 1362 1362 HOH TIP A . H 5 HOH 363 1363 1363 HOH TIP A . # loop_ _pdbx_struct_mod_residue.id _pdbx_struct_mod_residue.label_asym_id _pdbx_struct_mod_residue.label_comp_id _pdbx_struct_mod_residue.label_seq_id _pdbx_struct_mod_residue.auth_asym_id _pdbx_struct_mod_residue.auth_comp_id _pdbx_struct_mod_residue.auth_seq_id _pdbx_struct_mod_residue.PDB_ins_code _pdbx_struct_mod_residue.parent_comp_id _pdbx_struct_mod_residue.details 1 A ASN 116 A ASN 116 ? ASN 'GLYCOSYLATION SITE' 2 A ASN 513 A ASN 513 ? ASN 'GLYCOSYLATION SITE' # _pdbx_struct_assembly.id 1 _pdbx_struct_assembly.details author_defined_assembly _pdbx_struct_assembly.method_details ? _pdbx_struct_assembly.oligomeric_details monomeric _pdbx_struct_assembly.oligomeric_count 1 # _pdbx_struct_assembly_gen.assembly_id 1 _pdbx_struct_assembly_gen.oper_expression 1 _pdbx_struct_assembly_gen.asym_id_list A,B,C,D,E,F,G,H # _pdbx_struct_oper_list.id 1 _pdbx_struct_oper_list.type 'identity operation' _pdbx_struct_oper_list.name 1_555 _pdbx_struct_oper_list.symmetry_operation x,y,z _pdbx_struct_oper_list.matrix[1][1] 1.0000000000 _pdbx_struct_oper_list.matrix[1][2] 0.0000000000 _pdbx_struct_oper_list.matrix[1][3] 0.0000000000 _pdbx_struct_oper_list.vector[1] 0.0000000000 _pdbx_struct_oper_list.matrix[2][1] 0.0000000000 _pdbx_struct_oper_list.matrix[2][2] 1.0000000000 _pdbx_struct_oper_list.matrix[2][3] 0.0000000000 _pdbx_struct_oper_list.vector[2] 0.0000000000 _pdbx_struct_oper_list.matrix[3][1] 0.0000000000 _pdbx_struct_oper_list.matrix[3][2] 0.0000000000 _pdbx_struct_oper_list.matrix[3][3] 1.0000000000 _pdbx_struct_oper_list.vector[3] 0.0000000000 # loop_ _pdbx_audit_revision_history.ordinal _pdbx_audit_revision_history.data_content_type _pdbx_audit_revision_history.major_revision _pdbx_audit_revision_history.minor_revision _pdbx_audit_revision_history.revision_date 1 'Structure model' 1 0 2006-08-29 2 'Structure model' 1 1 2008-04-30 3 'Structure model' 1 2 2011-07-13 # _pdbx_audit_revision_details.ordinal 1 _pdbx_audit_revision_details.revision_ordinal 1 _pdbx_audit_revision_details.data_content_type 'Structure model' _pdbx_audit_revision_details.provider repository _pdbx_audit_revision_details.type 'Initial release' _pdbx_audit_revision_details.description ? # loop_ _pdbx_audit_revision_group.ordinal _pdbx_audit_revision_group.revision_ordinal _pdbx_audit_revision_group.data_content_type _pdbx_audit_revision_group.group 1 2 'Structure model' 'Version format compliance' 2 3 'Structure model' 'Non-polymer description' 3 3 'Structure model' 'Version format compliance' # loop_ _software.name _software.classification _software.version _software.citation_id _software.pdbx_ordinal CNS refinement 1.1 ? 1 DENZO 'data reduction' . ? 2 SCALEPACK 'data scaling' . ? 3 CNS phasing . ? 4 # _pdbx_validate_close_contact.id 1 _pdbx_validate_close_contact.PDB_model_num 1 _pdbx_validate_close_contact.auth_atom_id_1 NZ _pdbx_validate_close_contact.auth_asym_id_1 A _pdbx_validate_close_contact.auth_comp_id_1 LYS _pdbx_validate_close_contact.auth_seq_id_1 277 _pdbx_validate_close_contact.PDB_ins_code_1 ? _pdbx_validate_close_contact.label_alt_id_1 ? _pdbx_validate_close_contact.auth_atom_id_2 O _pdbx_validate_close_contact.auth_asym_id_2 A _pdbx_validate_close_contact.auth_comp_id_2 HOH _pdbx_validate_close_contact.auth_seq_id_2 1045 _pdbx_validate_close_contact.PDB_ins_code_2 ? _pdbx_validate_close_contact.label_alt_id_2 ? _pdbx_validate_close_contact.dist 2.10 # loop_ _pdbx_validate_torsion.id _pdbx_validate_torsion.PDB_model_num _pdbx_validate_torsion.auth_comp_id _pdbx_validate_torsion.auth_asym_id _pdbx_validate_torsion.auth_seq_id _pdbx_validate_torsion.PDB_ins_code _pdbx_validate_torsion.label_alt_id _pdbx_validate_torsion.phi _pdbx_validate_torsion.psi 1 1 TYR A 11 ? ? -140.06 20.06 2 1 ASN A 18 ? ? 74.39 -170.99 3 1 ASN A 21 ? ? -124.95 -115.72 4 1 ALA A 44 ? ? -98.22 30.85 5 1 THR A 73 ? ? -144.54 -12.94 6 1 ASP A 77 ? ? -150.76 24.25 7 1 SER A 80 ? ? 170.36 158.74 8 1 GLU A 138 ? ? -15.95 -85.41 9 1 ASP A 147 ? ? 62.67 67.00 10 1 ALA A 173 ? ? -118.45 79.99 11 1 PHE A 273 ? ? -162.01 117.87 12 1 GLN A 339 ? ? -103.36 -112.65 13 1 HIS A 478 ? ? 58.44 -99.17 14 1 GLN A 537 ? ? -118.28 -163.91 # loop_ _pdbx_unobs_or_zero_occ_residues.id _pdbx_unobs_or_zero_occ_residues.PDB_model_num _pdbx_unobs_or_zero_occ_residues.polymer_flag _pdbx_unobs_or_zero_occ_residues.occupancy_flag _pdbx_unobs_or_zero_occ_residues.auth_asym_id _pdbx_unobs_or_zero_occ_residues.auth_comp_id _pdbx_unobs_or_zero_occ_residues.auth_seq_id _pdbx_unobs_or_zero_occ_residues.PDB_ins_code _pdbx_unobs_or_zero_occ_residues.label_asym_id _pdbx_unobs_or_zero_occ_residues.label_comp_id _pdbx_unobs_or_zero_occ_residues.label_seq_id 1 1 Y 1 A GLN 1 ? A GLN 1 2 1 Y 1 A VAL 539 ? A VAL 539 3 1 Y 1 A LYS 540 ? A LYS 540 4 1 Y 1 A SER 541 ? A SER 541 5 1 Y 1 A ALA 542 ? A ALA 542 6 1 Y 1 A ALA 543 ? A ALA 543 # loop_ _pdbx_entity_nonpoly.entity_id _pdbx_entity_nonpoly.name _pdbx_entity_nonpoly.comp_id 2 N-ACETYL-D-GLUCOSAMINE NAG 3 ALPHA-D-MANNOSE MAN 4 SUCROSE SUC 5 water HOH #