data_1ZEB # _entry.id 1ZEB # _audit_conform.dict_name mmcif_pdbx.dic _audit_conform.dict_version 5.279 _audit_conform.dict_location http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic # loop_ _database_2.database_id _database_2.database_code PDB 1ZEB RCSB RCSB032624 WWPDB D_1000032624 # loop_ _pdbx_database_related.db_name _pdbx_database_related.db_id _pdbx_database_related.details _pdbx_database_related.content_type PDB 1EW2 'Crystal Structure Of A Human Phosphatase' unspecified PDB 1ZED . unspecified PDB 1ZEF . unspecified # _pdbx_database_status.status_code REL _pdbx_database_status.entry_id 1ZEB _pdbx_database_status.recvd_initial_deposition_date 2005-04-18 _pdbx_database_status.deposit_site RCSB _pdbx_database_status.process_site RCSB _pdbx_database_status.status_code_sf REL _pdbx_database_status.status_code_mr ? _pdbx_database_status.SG_entry ? _pdbx_database_status.pdb_format_compatible Y _pdbx_database_status.status_code_cs ? # loop_ _audit_author.name _audit_author.pdbx_ordinal 'Llinas, P.' 1 'Stura, E.A.' 2 'Menez, A.' 3 'Kiss, Z.' 4 'Stigbrand, T.' 5 'Millan, J.L.' 6 'Le Du, M.H.' 7 # _citation.id primary _citation.title 'Structural Studies of Human Placental Alkaline Phosphatase in Complex with Functional Ligands.' _citation.journal_abbrev J.Mol.Biol. _citation.journal_volume 350 _citation.page_first 441 _citation.page_last 451 _citation.year 2005 _citation.journal_id_ASTM JMOBAK _citation.country UK _citation.journal_id_ISSN 0022-2836 _citation.journal_id_CSD 0070 _citation.book_publisher ? _citation.pdbx_database_id_PubMed 15946677 _citation.pdbx_database_id_DOI 10.1016/j.jmb.2005.04.068 # loop_ _citation_author.citation_id _citation_author.name _citation_author.ordinal primary 'Llinas, P.' 1 primary 'Stura, E.A.' 2 primary 'Menez, A.' 3 primary 'Kiss, Z.' 4 primary 'Stigbrand, T.' 5 primary 'Millan, J.L.' 6 primary 'Le Du, M.H.' 7 # _cell.entry_id 1ZEB _cell.length_a 89.022 _cell.length_b 113.894 _cell.length_c 106.594 _cell.angle_alpha 90.00 _cell.angle_beta 90.00 _cell.angle_gamma 90.00 _cell.Z_PDB 8 _cell.pdbx_unique_axis ? # _symmetry.entry_id 1ZEB _symmetry.space_group_name_H-M 'C 2 2 21' _symmetry.pdbx_full_space_group_name_H-M ? _symmetry.cell_setting ? _symmetry.Int_Tables_number 20 # loop_ _entity.id _entity.type _entity.src_method _entity.pdbx_description _entity.formula_weight _entity.pdbx_number_of_molecules _entity.pdbx_ec _entity.pdbx_mutation _entity.pdbx_fragment _entity.details 1 polymer nat 'Alkaline phosphatase' 52888.105 1 3.1.3.1 ? ? ? 2 non-polymer man N-ACETYL-D-GLUCOSAMINE 221.208 2 ? ? ? ? 3 non-polymer syn 'ZINC ION' 65.409 2 ? ? ? ? 4 non-polymer syn 'MAGNESIUM ION' 24.305 1 ? ? ? ? 5 non-polymer syn 'CALCIUM ION' 40.078 1 ? ? ? ? 6 water nat water 18.015 710 ? ? ? ? # _entity_name_com.entity_id 1 _entity_name_com.name 'PLAP-1, Regan isozyme' # _entity_poly.entity_id 1 _entity_poly.type 'polypeptide(L)' _entity_poly.nstd_linkage no _entity_poly.nstd_monomer yes _entity_poly.pdbx_seq_one_letter_code ;IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALS KTYNVDKHVPD(SEP)GATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASP AGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQE WLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRID HGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNG PGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDL APPAGTTD ; _entity_poly.pdbx_seq_one_letter_code_can ;IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALS KTYNVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTY AHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAK RQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHH ESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYV LKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPPA GTTD ; _entity_poly.pdbx_strand_id A _entity_poly.pdbx_target_identifier ? # loop_ _entity_poly_seq.entity_id _entity_poly_seq.num _entity_poly_seq.mon_id _entity_poly_seq.hetero 1 1 ILE n 1 2 ILE n 1 3 PRO n 1 4 VAL n 1 5 GLU n 1 6 GLU n 1 7 GLU n 1 8 ASN n 1 9 PRO n 1 10 ASP n 1 11 PHE n 1 12 TRP n 1 13 ASN n 1 14 ARG n 1 15 GLU n 1 16 ALA n 1 17 ALA n 1 18 GLU n 1 19 ALA n 1 20 LEU n 1 21 GLY n 1 22 ALA n 1 23 ALA n 1 24 LYS n 1 25 LYS n 1 26 LEU n 1 27 GLN n 1 28 PRO n 1 29 ALA n 1 30 GLN n 1 31 THR n 1 32 ALA n 1 33 ALA n 1 34 LYS n 1 35 ASN n 1 36 LEU n 1 37 ILE n 1 38 ILE n 1 39 PHE n 1 40 LEU n 1 41 GLY n 1 42 ASP n 1 43 GLY n 1 44 MET n 1 45 GLY n 1 46 VAL n 1 47 SER n 1 48 THR n 1 49 VAL n 1 50 THR n 1 51 ALA n 1 52 ALA n 1 53 ARG n 1 54 ILE n 1 55 LEU n 1 56 LYS n 1 57 GLY n 1 58 GLN n 1 59 LYS n 1 60 LYS n 1 61 ASP n 1 62 LYS n 1 63 LEU n 1 64 GLY n 1 65 PRO n 1 66 GLU n 1 67 ILE n 1 68 PRO n 1 69 LEU n 1 70 ALA n 1 71 MET n 1 72 ASP n 1 73 ARG n 1 74 PHE n 1 75 PRO n 1 76 TYR n 1 77 VAL n 1 78 ALA n 1 79 LEU n 1 80 SER n 1 81 LYS n 1 82 THR n 1 83 TYR n 1 84 ASN n 1 85 VAL n 1 86 ASP n 1 87 LYS n 1 88 HIS n 1 89 VAL n 1 90 PRO n 1 91 ASP n 1 92 SEP n 1 93 GLY n 1 94 ALA n 1 95 THR n 1 96 ALA n 1 97 THR n 1 98 ALA n 1 99 TYR n 1 100 LEU n 1 101 CYS n 1 102 GLY n 1 103 VAL n 1 104 LYS n 1 105 GLY n 1 106 ASN n 1 107 PHE n 1 108 GLN n 1 109 THR n 1 110 ILE n 1 111 GLY n 1 112 LEU n 1 113 SER n 1 114 ALA n 1 115 ALA n 1 116 ALA n 1 117 ARG n 1 118 PHE n 1 119 ASN n 1 120 GLN n 1 121 CYS n 1 122 ASN n 1 123 THR n 1 124 THR n 1 125 ARG n 1 126 GLY n 1 127 ASN n 1 128 GLU n 1 129 VAL n 1 130 ILE n 1 131 SER n 1 132 VAL n 1 133 MET n 1 134 ASN n 1 135 ARG n 1 136 ALA n 1 137 LYS n 1 138 LYS n 1 139 ALA n 1 140 GLY n 1 141 LYS n 1 142 SER n 1 143 VAL n 1 144 GLY n 1 145 VAL n 1 146 VAL n 1 147 THR n 1 148 THR n 1 149 THR n 1 150 ARG n 1 151 VAL n 1 152 GLN n 1 153 HIS n 1 154 ALA n 1 155 SER n 1 156 PRO n 1 157 ALA n 1 158 GLY n 1 159 THR n 1 160 TYR n 1 161 ALA n 1 162 HIS n 1 163 THR n 1 164 VAL n 1 165 ASN n 1 166 ARG n 1 167 ASN n 1 168 TRP n 1 169 TYR n 1 170 SER n 1 171 ASP n 1 172 ALA n 1 173 ASP n 1 174 VAL n 1 175 PRO n 1 176 ALA n 1 177 SER n 1 178 ALA n 1 179 ARG n 1 180 GLN n 1 181 GLU n 1 182 GLY n 1 183 CYS n 1 184 GLN n 1 185 ASP n 1 186 ILE n 1 187 ALA n 1 188 THR n 1 189 GLN n 1 190 LEU n 1 191 ILE n 1 192 SER n 1 193 ASN n 1 194 MET n 1 195 ASP n 1 196 ILE n 1 197 ASP n 1 198 VAL n 1 199 ILE n 1 200 LEU n 1 201 GLY n 1 202 GLY n 1 203 GLY n 1 204 ARG n 1 205 LYS n 1 206 TYR n 1 207 MET n 1 208 PHE n 1 209 ARG n 1 210 MET n 1 211 GLY n 1 212 THR n 1 213 PRO n 1 214 ASP n 1 215 PRO n 1 216 GLU n 1 217 TYR n 1 218 PRO n 1 219 ASP n 1 220 ASP n 1 221 TYR n 1 222 SER n 1 223 GLN n 1 224 GLY n 1 225 GLY n 1 226 THR n 1 227 ARG n 1 228 LEU n 1 229 ASP n 1 230 GLY n 1 231 LYS n 1 232 ASN n 1 233 LEU n 1 234 VAL n 1 235 GLN n 1 236 GLU n 1 237 TRP n 1 238 LEU n 1 239 ALA n 1 240 LYS n 1 241 ARG n 1 242 GLN n 1 243 GLY n 1 244 ALA n 1 245 ARG n 1 246 TYR n 1 247 VAL n 1 248 TRP n 1 249 ASN n 1 250 ARG n 1 251 THR n 1 252 GLU n 1 253 LEU n 1 254 MET n 1 255 GLN n 1 256 ALA n 1 257 SER n 1 258 LEU n 1 259 ASP n 1 260 PRO n 1 261 SER n 1 262 VAL n 1 263 THR n 1 264 HIS n 1 265 LEU n 1 266 MET n 1 267 GLY n 1 268 LEU n 1 269 PHE n 1 270 GLU n 1 271 PRO n 1 272 GLY n 1 273 ASP n 1 274 MET n 1 275 LYS n 1 276 TYR n 1 277 GLU n 1 278 ILE n 1 279 HIS n 1 280 ARG n 1 281 ASP n 1 282 SER n 1 283 THR n 1 284 LEU n 1 285 ASP n 1 286 PRO n 1 287 SER n 1 288 LEU n 1 289 MET n 1 290 GLU n 1 291 MET n 1 292 THR n 1 293 GLU n 1 294 ALA n 1 295 ALA n 1 296 LEU n 1 297 ARG n 1 298 LEU n 1 299 LEU n 1 300 SER n 1 301 ARG n 1 302 ASN n 1 303 PRO n 1 304 ARG n 1 305 GLY n 1 306 PHE n 1 307 PHE n 1 308 LEU n 1 309 PHE n 1 310 VAL n 1 311 GLU n 1 312 GLY n 1 313 GLY n 1 314 ARG n 1 315 ILE n 1 316 ASP n 1 317 HIS n 1 318 GLY n 1 319 HIS n 1 320 HIS n 1 321 GLU n 1 322 SER n 1 323 ARG n 1 324 ALA n 1 325 TYR n 1 326 ARG n 1 327 ALA n 1 328 LEU n 1 329 THR n 1 330 GLU n 1 331 THR n 1 332 ILE n 1 333 MET n 1 334 PHE n 1 335 ASP n 1 336 ASP n 1 337 ALA n 1 338 ILE n 1 339 GLU n 1 340 ARG n 1 341 ALA n 1 342 GLY n 1 343 GLN n 1 344 LEU n 1 345 THR n 1 346 SER n 1 347 GLU n 1 348 GLU n 1 349 ASP n 1 350 THR n 1 351 LEU n 1 352 SER n 1 353 LEU n 1 354 VAL n 1 355 THR n 1 356 ALA n 1 357 ASP n 1 358 HIS n 1 359 SER n 1 360 HIS n 1 361 VAL n 1 362 PHE n 1 363 SER n 1 364 PHE n 1 365 GLY n 1 366 GLY n 1 367 TYR n 1 368 PRO n 1 369 LEU n 1 370 ARG n 1 371 GLY n 1 372 SER n 1 373 SER n 1 374 ILE n 1 375 PHE n 1 376 GLY n 1 377 LEU n 1 378 ALA n 1 379 PRO n 1 380 GLY n 1 381 LYS n 1 382 ALA n 1 383 ARG n 1 384 ASP n 1 385 ARG n 1 386 LYS n 1 387 ALA n 1 388 TYR n 1 389 THR n 1 390 VAL n 1 391 LEU n 1 392 LEU n 1 393 TYR n 1 394 GLY n 1 395 ASN n 1 396 GLY n 1 397 PRO n 1 398 GLY n 1 399 TYR n 1 400 VAL n 1 401 LEU n 1 402 LYS n 1 403 ASP n 1 404 GLY n 1 405 ALA n 1 406 ARG n 1 407 PRO n 1 408 ASP n 1 409 VAL n 1 410 THR n 1 411 GLU n 1 412 SER n 1 413 GLU n 1 414 SER n 1 415 GLY n 1 416 SER n 1 417 PRO n 1 418 GLU n 1 419 TYR n 1 420 ARG n 1 421 GLN n 1 422 GLN n 1 423 SER n 1 424 ALA n 1 425 VAL n 1 426 PRO n 1 427 LEU n 1 428 ASP n 1 429 GLU n 1 430 GLU n 1 431 THR n 1 432 HIS n 1 433 ALA n 1 434 GLY n 1 435 GLU n 1 436 ASP n 1 437 VAL n 1 438 ALA n 1 439 VAL n 1 440 PHE n 1 441 ALA n 1 442 ARG n 1 443 GLY n 1 444 PRO n 1 445 GLN n 1 446 ALA n 1 447 HIS n 1 448 LEU n 1 449 VAL n 1 450 HIS n 1 451 GLY n 1 452 VAL n 1 453 GLN n 1 454 GLU n 1 455 GLN n 1 456 THR n 1 457 PHE n 1 458 ILE n 1 459 ALA n 1 460 HIS n 1 461 VAL n 1 462 MET n 1 463 ALA n 1 464 PHE n 1 465 ALA n 1 466 ALA n 1 467 CYS n 1 468 LEU n 1 469 GLU n 1 470 PRO n 1 471 TYR n 1 472 THR n 1 473 ALA n 1 474 CYS n 1 475 ASP n 1 476 LEU n 1 477 ALA n 1 478 PRO n 1 479 PRO n 1 480 ALA n 1 481 GLY n 1 482 THR n 1 483 THR n 1 484 ASP n # _entity_src_nat.entity_id 1 _entity_src_nat.pdbx_src_id 1 _entity_src_nat.pdbx_alt_source_flag sample _entity_src_nat.pdbx_beg_seq_num ? _entity_src_nat.pdbx_end_seq_num ? _entity_src_nat.common_name human _entity_src_nat.pdbx_organism_scientific 'Homo sapiens' _entity_src_nat.pdbx_ncbi_taxonomy_id 9606 _entity_src_nat.genus Homo _entity_src_nat.species ? _entity_src_nat.strain ? _entity_src_nat.tissue placenta _entity_src_nat.tissue_fraction ? _entity_src_nat.pdbx_secretion ? _entity_src_nat.pdbx_fragment ? _entity_src_nat.pdbx_variant ? _entity_src_nat.pdbx_cell_line ? _entity_src_nat.pdbx_atcc ? _entity_src_nat.pdbx_cellular_location ? _entity_src_nat.pdbx_organ ? _entity_src_nat.pdbx_organelle ? _entity_src_nat.pdbx_cell ? _entity_src_nat.pdbx_plasmid_name ? _entity_src_nat.pdbx_plasmid_details ? _entity_src_nat.details ? # _struct_ref.id 1 _struct_ref.db_name UNP _struct_ref.db_code PPB1_HUMAN _struct_ref.pdbx_db_accession P05187 _struct_ref.entity_id 1 _struct_ref.pdbx_seq_one_letter_code ;IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALS KTYNVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTY AHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAK RQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHH ESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYV LKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPPA GTTD ; _struct_ref.pdbx_align_begin 23 _struct_ref.pdbx_db_isoform ? # _struct_ref_seq.align_id 1 _struct_ref_seq.ref_id 1 _struct_ref_seq.pdbx_PDB_id_code 1ZEB _struct_ref_seq.pdbx_strand_id A _struct_ref_seq.seq_align_beg 1 _struct_ref_seq.pdbx_seq_align_beg_ins_code ? _struct_ref_seq.seq_align_end 484 _struct_ref_seq.pdbx_seq_align_end_ins_code ? _struct_ref_seq.pdbx_db_accession P05187 _struct_ref_seq.db_align_beg 23 _struct_ref_seq.pdbx_db_align_beg_ins_code ? _struct_ref_seq.db_align_end 506 _struct_ref_seq.pdbx_db_align_end_ins_code ? _struct_ref_seq.pdbx_auth_seq_align_beg 1 _struct_ref_seq.pdbx_auth_seq_align_end 484 # loop_ _chem_comp.id _chem_comp.type _chem_comp.mon_nstd_flag _chem_comp.name _chem_comp.pdbx_synonyms _chem_comp.formula _chem_comp.formula_weight ALA 'L-peptide linking' y ALANINE ? 'C3 H7 N O2' 89.093 ARG 'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1' 175.209 ASN 'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3' 132.118 ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4' 133.103 CA non-polymer . 'CALCIUM ION' ? 'Ca 2' 40.078 CYS 'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S' 121.158 GLN 'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3' 146.144 GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4' 147.129 GLY 'peptide linking' y GLYCINE ? 'C2 H5 N O2' 75.067 HIS 'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1' 156.162 HOH non-polymer . WATER ? 'H2 O' 18.015 ILE 'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2' 131.173 LEU 'L-peptide linking' y LEUCINE ? 'C6 H13 N O2' 131.173 LYS 'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1' 147.195 MET 'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S' 149.211 MG non-polymer . 'MAGNESIUM ION' ? 'Mg 2' 24.305 NAG D-saccharide . N-ACETYL-D-GLUCOSAMINE ? 'C8 H15 N O6' 221.208 PHE 'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2' 165.189 PRO 'L-peptide linking' y PROLINE ? 'C5 H9 N O2' 115.130 SEP 'L-peptide linking' n PHOSPHOSERINE PHOSPHONOSERINE 'C3 H8 N O6 P' 185.072 SER 'L-peptide linking' y SERINE ? 'C3 H7 N O3' 105.093 THR 'L-peptide linking' y THREONINE ? 'C4 H9 N O3' 119.119 TRP 'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2' 204.225 TYR 'L-peptide linking' y TYROSINE ? 'C9 H11 N O3' 181.189 VAL 'L-peptide linking' y VALINE ? 'C5 H11 N O2' 117.146 ZN non-polymer . 'ZINC ION' ? 'Zn 2' 65.409 # _exptl.entry_id 1ZEB _exptl.method 'X-RAY DIFFRACTION' _exptl.crystals_number 1 # _exptl_crystal.id 1 _exptl_crystal.density_meas ? _exptl_crystal.density_Matthews 2.74 _exptl_crystal.density_percent_sol 50 _exptl_crystal.description ? _exptl_crystal.F_000 ? _exptl_crystal.preparation ? # _exptl_crystal_grow.crystal_id 1 _exptl_crystal_grow.method 'VAPOR DIFFUSION, SITTING DROP' _exptl_crystal_grow.temp 295 _exptl_crystal_grow.temp_details ? _exptl_crystal_grow.pH 7.0 _exptl_crystal_grow.pdbx_details 'PEG, pH 7.0, VAPOR DIFFUSION, SITTING DROP, temperature 295K' _exptl_crystal_grow.pdbx_pH_range . # _diffrn.id 1 _diffrn.ambient_temp 110 _diffrn.ambient_temp_details ? _diffrn.crystal_id 1 # _diffrn_detector.diffrn_id 1 _diffrn_detector.detector CCD _diffrn_detector.type 'ADSC QUANTUM 4' _diffrn_detector.pdbx_collection_date 2001-06-06 _diffrn_detector.details ? # _diffrn_radiation.diffrn_id 1 _diffrn_radiation.wavelength_id 1 _diffrn_radiation.pdbx_monochromatic_or_laue_m_l M _diffrn_radiation.monochromator ? _diffrn_radiation.pdbx_diffrn_protocol 'SINGLE WAVELENGTH' _diffrn_radiation.pdbx_scattering_type x-ray # _diffrn_radiation_wavelength.id 1 _diffrn_radiation_wavelength.wavelength 0.98 _diffrn_radiation_wavelength.wt 1.0 # _diffrn_source.diffrn_id 1 _diffrn_source.source SYNCHROTRON _diffrn_source.type 'ESRF BEAMLINE ID29' _diffrn_source.pdbx_synchrotron_site ESRF _diffrn_source.pdbx_synchrotron_beamline ID29 _diffrn_source.pdbx_wavelength ? _diffrn_source.pdbx_wavelength_list 0.98 # _reflns.entry_id 1ZEB _reflns.observed_criterion_sigma_F 0 _reflns.observed_criterion_sigma_I 0 _reflns.d_resolution_high 1.90 _reflns.d_resolution_low 99 _reflns.number_all 48000 _reflns.number_obs 37407 _reflns.percent_possible_obs 77 _reflns.pdbx_Rmerge_I_obs ? _reflns.pdbx_Rsym_value 0.083 _reflns.pdbx_netI_over_sigmaI ? _reflns.B_iso_Wilson_estimate ? _reflns.pdbx_redundancy ? _reflns.R_free_details ? _reflns.limit_h_max ? _reflns.limit_h_min ? _reflns.limit_k_max ? _reflns.limit_k_min ? _reflns.limit_l_max ? _reflns.limit_l_min ? _reflns.observed_criterion_F_max ? _reflns.observed_criterion_F_min ? _reflns.pdbx_chi_squared ? _reflns.pdbx_scaling_rejects ? _reflns.pdbx_ordinal 1 _reflns.pdbx_diffrn_id 1 # _reflns_shell.d_res_high 1.90 _reflns_shell.d_res_low 1.94 _reflns_shell.percent_possible_all 76.8 _reflns_shell.Rmerge_I_obs 0.4 _reflns_shell.pdbx_Rsym_value ? _reflns_shell.meanI_over_sigI_obs ? _reflns_shell.pdbx_redundancy ? _reflns_shell.percent_possible_obs ? _reflns_shell.number_unique_all ? _reflns_shell.number_measured_all ? _reflns_shell.number_measured_obs ? _reflns_shell.number_unique_obs ? _reflns_shell.pdbx_chi_squared ? _reflns_shell.pdbx_ordinal 1 _reflns_shell.pdbx_diffrn_id 1 # _refine.entry_id 1ZEB _refine.ls_number_reflns_obs 35450 _refine.ls_number_reflns_all 37403 _refine.pdbx_ls_sigma_I ? _refine.pdbx_ls_sigma_F 0 _refine.pdbx_data_cutoff_high_absF ? _refine.pdbx_data_cutoff_low_absF ? _refine.pdbx_data_cutoff_high_rms_absF ? _refine.ls_d_res_low 14.96 _refine.ls_d_res_high 1.90 _refine.ls_percent_reflns_obs 100.00 _refine.ls_R_factor_obs 0.1534 _refine.ls_R_factor_all 0.1534 _refine.ls_R_factor_R_work 0.15108 _refine.ls_R_factor_R_free 0.19703 _refine.ls_R_factor_R_free_error ? _refine.ls_R_factor_R_free_error_details ? _refine.ls_percent_reflns_R_free 5.0 _refine.ls_number_reflns_R_free 1869 _refine.ls_number_parameters ? _refine.ls_number_restraints ? _refine.occupancy_min ? _refine.occupancy_max ? _refine.correlation_coeff_Fo_to_Fc 0.966 _refine.correlation_coeff_Fo_to_Fc_free 0.946 _refine.B_iso_mean 17.303 _refine.aniso_B[1][1] 0.00 _refine.aniso_B[2][2] 0.01 _refine.aniso_B[3][3] 0.00 _refine.aniso_B[1][2] 0.00 _refine.aniso_B[1][3] 0.00 _refine.aniso_B[2][3] 0.00 _refine.solvent_model_details 'BABINET MODEL WITH MASK' _refine.solvent_model_param_ksol ? _refine.solvent_model_param_bsol ? _refine.pdbx_solvent_vdw_probe_radii 1.20 _refine.pdbx_solvent_ion_probe_radii 0.80 _refine.pdbx_solvent_shrinkage_radii 0.80 _refine.pdbx_ls_cross_valid_method THROUGHOUT _refine.details 'HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS' _refine.pdbx_starting_model ? _refine.pdbx_method_to_determine_struct 'FOURIER SYNTHESIS' _refine.pdbx_isotropic_thermal_model ? _refine.pdbx_stereochemistry_target_values 'MAXIMUM LIKELIHOOD' _refine.pdbx_stereochem_target_val_spec_case ? _refine.pdbx_R_Free_selection_details RANDOM _refine.pdbx_overall_ESU_R 0.146 _refine.pdbx_overall_ESU_R_Free 0.134 _refine.overall_SU_ML 0.086 _refine.overall_SU_B 2.912 _refine.ls_redundancy_reflns_obs ? _refine.B_iso_min ? _refine.B_iso_max ? _refine.overall_SU_R_Cruickshank_DPI ? _refine.overall_SU_R_free ? _refine.ls_wR_factor_R_free ? _refine.ls_wR_factor_R_work ? _refine.overall_FOM_free_R_set ? _refine.overall_FOM_work_R_set ? _refine.pdbx_refine_id 'X-RAY DIFFRACTION' _refine.pdbx_diffrn_id 1 _refine.pdbx_TLS_residual_ADP_flag ? _refine.pdbx_overall_phase_error ? _refine.pdbx_overall_SU_R_free_Cruickshank_DPI ? _refine.pdbx_overall_SU_R_Blow_DPI ? _refine.pdbx_overall_SU_R_free_Blow_DPI ? # _refine_hist.pdbx_refine_id 'X-RAY DIFFRACTION' _refine_hist.cycle_id LAST _refine_hist.pdbx_number_atoms_protein 3677 _refine_hist.pdbx_number_atoms_nucleic_acid 0 _refine_hist.pdbx_number_atoms_ligand 32 _refine_hist.number_atoms_solvent 710 _refine_hist.number_atoms_total 4419 _refine_hist.d_res_high 1.90 _refine_hist.d_res_low 14.96 # loop_ _refine_ls_restr.type _refine_ls_restr.dev_ideal _refine_ls_restr.dev_ideal_target _refine_ls_restr.weight _refine_ls_restr.number _refine_ls_restr.pdbx_refine_id _refine_ls_restr.pdbx_restraint_function r_bond_refined_d 0.010 0.021 ? 3807 'X-RAY DIFFRACTION' ? r_bond_other_d 0.002 0.020 ? 3382 'X-RAY DIFFRACTION' ? r_angle_refined_deg 1.337 1.948 ? 5143 'X-RAY DIFFRACTION' ? r_angle_other_deg 0.843 3.000 ? 7850 'X-RAY DIFFRACTION' ? r_dihedral_angle_1_deg 6.530 5.000 ? 479 'X-RAY DIFFRACTION' ? r_dihedral_angle_2_deg 34.451 23.642 ? 173 'X-RAY DIFFRACTION' ? r_dihedral_angle_3_deg 13.959 15.000 ? 601 'X-RAY DIFFRACTION' ? r_dihedral_angle_4_deg 18.000 15.000 ? 29 'X-RAY DIFFRACTION' ? r_chiral_restr 0.082 0.200 ? 562 'X-RAY DIFFRACTION' ? r_gen_planes_refined 0.004 0.020 ? 4283 'X-RAY DIFFRACTION' ? r_gen_planes_other 0.001 0.020 ? 770 'X-RAY DIFFRACTION' ? r_nbd_refined 0.204 0.200 ? 1023 'X-RAY DIFFRACTION' ? r_nbd_other 0.191 0.200 ? 3928 'X-RAY DIFFRACTION' ? r_nbtor_refined 0.178 0.200 ? 1951 'X-RAY DIFFRACTION' ? r_nbtor_other 0.084 0.200 ? 2218 'X-RAY DIFFRACTION' ? r_xyhbond_nbd_refined 0.167 0.200 ? 581 'X-RAY DIFFRACTION' ? r_metal_ion_refined 0.003 0.200 ? 1 'X-RAY DIFFRACTION' ? r_symmetry_vdw_refined 0.199 0.200 ? 23 'X-RAY DIFFRACTION' ? r_symmetry_vdw_other 0.247 0.200 ? 167 'X-RAY DIFFRACTION' ? r_symmetry_hbond_refined 0.227 0.200 ? 67 'X-RAY DIFFRACTION' ? r_mcbond_it 0.672 1.500 ? 2460 'X-RAY DIFFRACTION' ? r_mcbond_other 0.139 1.500 ? 979 'X-RAY DIFFRACTION' ? r_mcangle_it 0.978 2.000 ? 3811 'X-RAY DIFFRACTION' ? r_scbond_it 1.567 3.000 ? 1517 'X-RAY DIFFRACTION' ? r_scangle_it 2.450 4.500 ? 1332 'X-RAY DIFFRACTION' ? # _refine_ls_shell.pdbx_total_number_of_bins_used 20 _refine_ls_shell.d_res_high 1.900 _refine_ls_shell.d_res_low 1.949 _refine_ls_shell.number_reflns_R_work 2608 _refine_ls_shell.R_factor_R_work 0.203 _refine_ls_shell.percent_reflns_obs 100.00 _refine_ls_shell.R_factor_R_free 0.282 _refine_ls_shell.R_factor_R_free_error ? _refine_ls_shell.percent_reflns_R_free ? _refine_ls_shell.number_reflns_R_free 137 _refine_ls_shell.number_reflns_obs ? _refine_ls_shell.redundancy_reflns_obs ? _refine_ls_shell.number_reflns_all ? _refine_ls_shell.pdbx_refine_id 'X-RAY DIFFRACTION' _refine_ls_shell.R_factor_all ? # _struct.entry_id 1ZEB _struct.title ;X-ray structure of alkaline phosphatase from human placenta in complex with 5'-AMP ; _struct.pdbx_descriptor 'Alkaline phosphatase (E.C.3.1.3.1)' _struct.pdbx_model_details ? _struct.pdbx_CASP_flag ? _struct.pdbx_model_type_details ? # _struct_keywords.entry_id 1ZEB _struct_keywords.pdbx_keywords HYDROLASE _struct_keywords.text ;ALKALINE PHOSPHATASE, 5'-AMP, PHOSPHOSERINE, HYDROLASE ; # loop_ _struct_asym.id _struct_asym.pdbx_blank_PDB_chainid_flag _struct_asym.pdbx_modified _struct_asym.entity_id _struct_asym.details A N N 1 ? B N N 2 ? C N N 2 ? D N N 3 ? E N N 3 ? F N N 4 ? G N N 5 ? H N N 6 ? # _struct_biol.id 1 _struct_biol.pdbx_parent_biol_id ? _struct_biol.details ? # loop_ _struct_conf.conf_type_id _struct_conf.id _struct_conf.pdbx_PDB_helix_id _struct_conf.beg_label_comp_id _struct_conf.beg_label_asym_id _struct_conf.beg_label_seq_id _struct_conf.pdbx_beg_PDB_ins_code _struct_conf.end_label_comp_id _struct_conf.end_label_asym_id _struct_conf.end_label_seq_id _struct_conf.pdbx_end_PDB_ins_code _struct_conf.beg_auth_comp_id _struct_conf.beg_auth_asym_id _struct_conf.beg_auth_seq_id _struct_conf.end_auth_comp_id _struct_conf.end_auth_asym_id _struct_conf.end_auth_seq_id _struct_conf.pdbx_PDB_helix_class _struct_conf.details _struct_conf.pdbx_PDB_helix_length HELX_P HELX_P1 1 PRO A 3 ? GLU A 7 ? PRO A 3 GLU A 7 5 ? 5 HELX_P HELX_P2 2 ASN A 8 ? LEU A 26 ? ASN A 8 LEU A 26 1 ? 19 HELX_P HELX_P3 3 GLY A 45 ? LYS A 60 ? GLY A 45 LYS A 60 1 ? 16 HELX_P HELX_P4 4 ALA A 70 ? PHE A 74 ? ALA A 70 PHE A 74 5 ? 5 HELX_P HELX_P5 5 ASP A 91 ? GLY A 102 ? ASP A 91 GLY A 102 1 ? 12 HELX_P HELX_P6 6 GLN A 120 ? THR A 124 ? GLN A 120 THR A 124 5 ? 5 HELX_P HELX_P7 7 SER A 131 ? ALA A 139 ? SER A 131 ALA A 139 1 ? 9 HELX_P HELX_P8 8 HIS A 153 ? GLY A 158 ? HIS A 153 GLY A 158 1 ? 6 HELX_P HELX_P9 9 SER A 170 ? VAL A 174 ? SER A 170 VAL A 174 5 ? 5 HELX_P HELX_P10 10 PRO A 175 ? GLU A 181 ? PRO A 175 GLU A 181 1 ? 7 HELX_P HELX_P11 11 ASP A 185 ? ASN A 193 ? ASP A 185 ASN A 193 1 ? 9 HELX_P HELX_P12 12 GLY A 203 ? PHE A 208 ? GLY A 203 PHE A 208 5 ? 6 HELX_P HELX_P13 13 ASP A 220 ? GLY A 224 ? ASP A 220 GLY A 224 5 ? 5 HELX_P HELX_P14 14 ASN A 232 ? LYS A 240 ? ASN A 232 LYS A 240 1 ? 9 HELX_P HELX_P15 15 ASN A 249 ? ASP A 259 ? ASN A 249 ASP A 259 1 ? 11 HELX_P HELX_P16 16 TYR A 276 ? ARG A 280 ? TYR A 276 ARG A 280 5 ? 5 HELX_P HELX_P17 17 SER A 287 ? SER A 300 ? SER A 287 SER A 300 1 ? 14 HELX_P HELX_P18 18 ARG A 314 ? GLU A 321 ? ARG A 314 GLU A 321 1 ? 8 HELX_P HELX_P19 19 ARG A 323 ? THR A 345 ? ARG A 323 THR A 345 1 ? 23 HELX_P HELX_P20 20 THR A 410 ? GLY A 415 ? THR A 410 GLY A 415 1 ? 6 HELX_P HELX_P21 21 GLN A 445 ? VAL A 449 ? GLN A 445 VAL A 449 5 ? 5 HELX_P HELX_P22 22 THR A 456 ? ALA A 466 ? THR A 456 ALA A 466 1 ? 11 HELX_P HELX_P23 23 LEU A 468 ? THR A 472 ? LEU A 468 THR A 472 5 ? 5 # _struct_conf_type.id HELX_P _struct_conf_type.criteria ? _struct_conf_type.reference ? # loop_ _struct_conn.id _struct_conn.conn_type_id _struct_conn.pdbx_leaving_atom_flag _struct_conn.pdbx_PDB_id _struct_conn.ptnr1_label_asym_id _struct_conn.ptnr1_label_comp_id _struct_conn.ptnr1_label_seq_id _struct_conn.ptnr1_label_atom_id _struct_conn.pdbx_ptnr1_label_alt_id _struct_conn.pdbx_ptnr1_PDB_ins_code _struct_conn.pdbx_ptnr1_standard_comp_id _struct_conn.ptnr1_symmetry _struct_conn.ptnr2_label_asym_id _struct_conn.ptnr2_label_comp_id _struct_conn.ptnr2_label_seq_id _struct_conn.ptnr2_label_atom_id _struct_conn.pdbx_ptnr2_label_alt_id _struct_conn.pdbx_ptnr2_PDB_ins_code _struct_conn.ptnr1_auth_asym_id _struct_conn.ptnr1_auth_comp_id _struct_conn.ptnr1_auth_seq_id _struct_conn.ptnr2_auth_asym_id _struct_conn.ptnr2_auth_comp_id _struct_conn.ptnr2_auth_seq_id _struct_conn.ptnr2_symmetry _struct_conn.pdbx_ptnr3_label_atom_id _struct_conn.pdbx_ptnr3_label_seq_id _struct_conn.pdbx_ptnr3_label_comp_id _struct_conn.pdbx_ptnr3_label_asym_id _struct_conn.pdbx_ptnr3_label_alt_id _struct_conn.pdbx_ptnr3_PDB_ins_code _struct_conn.details _struct_conn.pdbx_dist_value _struct_conn.pdbx_value_order disulf1 disulf ? ? A CYS 121 SG ? ? ? 1_555 A CYS 183 SG ? ? A CYS 121 A CYS 183 1_555 ? ? ? ? ? ? ? 2.035 ? disulf2 disulf ? ? A CYS 467 SG ? ? ? 1_555 A CYS 474 SG ? ? A CYS 467 A CYS 474 1_555 ? ? ? ? ? ? ? 2.038 ? covale1 covale ? ? A ASP 91 C ? ? ? 1_555 A SEP 92 N ? ? A ASP 91 A SEP 92 1_555 ? ? ? ? ? ? ? 1.326 ? covale2 covale ? ? A SEP 92 C ? ? ? 1_555 A GLY 93 N ? ? A SEP 92 A GLY 93 1_555 ? ? ? ? ? ? ? 1.333 ? metalc1 metalc ? ? A ASP 42 OD1 ? ? ? 1_555 E ZN . ZN ? ? A ASP 42 A ZN 902 1_555 ? ? ? ? ? ? ? 1.977 ? metalc2 metalc ? ? A ASP 42 OD2 ? ? ? 1_555 F MG . MG ? ? A ASP 42 A MG 903 1_555 ? ? ? ? ? ? ? 2.138 ? metalc3 metalc ? ? A SEP 92 OG ? ? ? 1_555 E ZN . ZN ? ? A SEP 92 A ZN 902 1_555 ? ? ? ? ? ? ? 2.182 ? metalc4 metalc ? ? A SEP 92 O3P ? ? ? 1_555 D ZN . ZN ? ? A SEP 92 A ZN 901 1_555 ? ? ? ? ? ? ? 2.072 ? metalc5 metalc ? ? A SEP 92 O3P ? ? ? 1_555 E ZN . ZN ? ? A SEP 92 A ZN 902 1_555 ? ? ? ? ? ? ? 2.088 ? covale3 covale ? ? A ASN 122 ND2 ? ? ? 1_555 B NAG . C1 ? ? A ASN 122 A NAG 801 1_555 ? ? ? ? ? ? ? 1.437 ? metalc6 metalc ? ? A SER 155 OG ? ? ? 1_555 F MG . MG ? ? A SER 155 A MG 903 1_555 ? ? ? ? ? ? ? 2.189 ? metalc7 metalc ? ? A GLU 216 OE1 ? ? ? 1_555 G CA . CA ? ? A GLU 216 A CA 904 1_555 ? ? ? ? ? ? ? 2.327 ? metalc8 metalc ? ? A GLU 216 OE2 ? ? ? 1_555 G CA . CA ? ? A GLU 216 A CA 904 1_555 ? ? ? ? ? ? ? 2.322 ? covale4 covale ? ? A ASN 249 ND2 ? ? ? 1_555 C NAG . C1 ? ? A ASN 249 A NAG 803 1_555 ? ? ? ? ? ? ? 1.456 ? metalc9 metalc ? ? A PHE 269 O ? ? ? 1_555 G CA . CA ? ? A PHE 269 A CA 904 1_555 ? ? ? ? ? ? ? 2.418 ? metalc10 metalc ? ? A GLU 270 OE2 ? ? ? 1_555 G CA . CA ? ? A GLU 270 A CA 904 1_555 ? ? ? ? ? ? ? 2.320 ? metalc11 metalc ? ? A ASP 285 OD1 ? ? ? 1_555 G CA . CA ? ? A ASP 285 A CA 904 1_555 ? ? ? ? ? ? ? 2.592 ? metalc12 metalc ? ? A ASP 285 OD2 ? ? ? 1_555 G CA . CA ? ? A ASP 285 A CA 904 1_555 ? ? ? ? ? ? ? 2.323 ? metalc13 metalc ? ? A GLU 311 OE2 ? ? ? 1_555 F MG . MG ? ? A GLU 311 A MG 903 1_555 ? ? ? ? ? ? ? 2.134 ? metalc14 metalc ? ? A ASP 316 OD1 ? ? ? 1_555 D ZN . ZN ? ? A ASP 316 A ZN 901 1_555 ? ? ? ? ? ? ? 2.010 ? metalc15 metalc ? ? A ASP 316 OD2 ? ? ? 1_555 D ZN . ZN ? ? A ASP 316 A ZN 901 1_555 ? ? ? ? ? ? ? 2.076 ? metalc16 metalc ? ? A HIS 320 NE2 ? ? ? 1_555 D ZN . ZN ? ? A HIS 320 A ZN 901 1_555 ? ? ? ? ? ? ? 2.080 ? metalc17 metalc ? ? A ASP 357 OD2 ? ? ? 1_555 E ZN . ZN ? ? A ASP 357 A ZN 902 1_555 ? ? ? ? ? ? ? 1.994 ? metalc18 metalc ? ? A HIS 358 NE2 ? ? ? 1_555 E ZN . ZN ? ? A HIS 358 A ZN 902 1_555 ? ? ? ? ? ? ? 2.064 ? metalc19 metalc ? ? A HIS 432 NE2 ? ? ? 1_555 D ZN . ZN ? ? A HIS 432 A ZN 901 1_555 ? ? ? ? ? ? ? 2.060 ? metalc20 metalc ? ? F MG . MG ? ? ? 1_555 H HOH . O ? ? A MG 903 A HOH 937 1_555 ? ? ? ? ? ? ? 2.163 ? metalc21 metalc ? ? F MG . MG ? ? ? 1_555 H HOH . O ? ? A MG 903 A HOH 927 1_555 ? ? ? ? ? ? ? 2.007 ? metalc22 metalc ? ? F MG . MG ? ? ? 1_555 H HOH . O ? ? A MG 903 A HOH 910 1_555 ? ? ? ? ? ? ? 2.115 ? metalc23 metalc ? ? G CA . CA ? ? ? 1_555 H HOH . O ? ? A CA 904 A HOH 995 1_555 ? ? ? ? ? ? ? 2.443 ? # loop_ _struct_conn_type.id _struct_conn_type.criteria _struct_conn_type.reference disulf ? ? covale ? ? metalc ? ? # loop_ _struct_sheet.id _struct_sheet.type _struct_sheet.number_strands _struct_sheet.details A ? 10 ? B ? 2 ? C ? 2 ? # loop_ _struct_sheet_order.sheet_id _struct_sheet_order.range_id_1 _struct_sheet_order.range_id_2 _struct_sheet_order.offset _struct_sheet_order.sense A 1 2 ? parallel A 2 3 ? parallel A 3 4 ? parallel A 4 5 ? parallel A 5 6 ? parallel A 6 7 ? parallel A 7 8 ? anti-parallel A 8 9 ? anti-parallel A 9 10 ? parallel B 1 2 ? anti-parallel C 1 2 ? anti-parallel # loop_ _struct_sheet_range.sheet_id _struct_sheet_range.id _struct_sheet_range.beg_label_comp_id _struct_sheet_range.beg_label_asym_id _struct_sheet_range.beg_label_seq_id _struct_sheet_range.pdbx_beg_PDB_ins_code _struct_sheet_range.end_label_comp_id _struct_sheet_range.end_label_asym_id _struct_sheet_range.end_label_seq_id _struct_sheet_range.pdbx_end_PDB_ins_code _struct_sheet_range.beg_auth_comp_id _struct_sheet_range.beg_auth_asym_id _struct_sheet_range.beg_auth_seq_id _struct_sheet_range.end_auth_comp_id _struct_sheet_range.end_auth_asym_id _struct_sheet_range.end_auth_seq_id A 1 ALA A 244 ? VAL A 247 ? ALA A 244 VAL A 247 A 2 HIS A 264 ? LEU A 268 ? HIS A 264 LEU A 268 A 3 VAL A 198 ? GLY A 202 ? VAL A 198 GLY A 202 A 4 SER A 142 ? ARG A 150 ? SER A 142 ARG A 150 A 5 PHE A 306 ? GLY A 312 ? PHE A 306 GLY A 312 A 6 ASN A 35 ? GLY A 41 ? ASN A 35 GLY A 41 A 7 THR A 350 ? ALA A 356 ? THR A 350 ALA A 356 A 8 VAL A 437 ? ARG A 442 ? VAL A 437 ARG A 442 A 9 TYR A 76 ? LYS A 81 ? TYR A 76 LYS A 81 A 10 VAL A 452 ? GLU A 454 ? VAL A 452 GLU A 454 B 1 SER A 359 ? HIS A 360 ? SER A 359 HIS A 360 B 2 HIS A 432 ? ALA A 433 ? HIS A 432 ALA A 433 C 1 PHE A 362 ? PHE A 364 ? PHE A 362 PHE A 364 C 2 LEU A 391 ? TYR A 393 ? LEU A 391 TYR A 393 # loop_ _pdbx_struct_sheet_hbond.sheet_id _pdbx_struct_sheet_hbond.range_id_1 _pdbx_struct_sheet_hbond.range_id_2 _pdbx_struct_sheet_hbond.range_1_label_atom_id _pdbx_struct_sheet_hbond.range_1_label_comp_id _pdbx_struct_sheet_hbond.range_1_label_asym_id _pdbx_struct_sheet_hbond.range_1_label_seq_id _pdbx_struct_sheet_hbond.range_1_PDB_ins_code _pdbx_struct_sheet_hbond.range_1_auth_atom_id _pdbx_struct_sheet_hbond.range_1_auth_comp_id _pdbx_struct_sheet_hbond.range_1_auth_asym_id _pdbx_struct_sheet_hbond.range_1_auth_seq_id _pdbx_struct_sheet_hbond.range_2_label_atom_id _pdbx_struct_sheet_hbond.range_2_label_comp_id _pdbx_struct_sheet_hbond.range_2_label_asym_id _pdbx_struct_sheet_hbond.range_2_label_seq_id _pdbx_struct_sheet_hbond.range_2_PDB_ins_code _pdbx_struct_sheet_hbond.range_2_auth_atom_id _pdbx_struct_sheet_hbond.range_2_auth_comp_id _pdbx_struct_sheet_hbond.range_2_auth_asym_id _pdbx_struct_sheet_hbond.range_2_auth_seq_id A 1 2 N ARG A 245 ? N ARG A 245 O MET A 266 ? O MET A 266 A 2 3 O GLY A 267 ? O GLY A 267 N ILE A 199 ? N ILE A 199 A 3 4 O LEU A 200 ? O LEU A 200 N VAL A 145 ? N VAL A 145 A 4 5 N GLY A 144 ? N GLY A 144 O PHE A 309 ? O PHE A 309 A 5 6 O LEU A 308 ? O LEU A 308 N LEU A 36 ? N LEU A 36 A 6 7 N PHE A 39 ? N PHE A 39 O LEU A 353 ? O LEU A 353 A 7 8 N VAL A 354 ? N VAL A 354 O PHE A 440 ? O PHE A 440 A 8 9 O VAL A 437 ? O VAL A 437 N SER A 80 ? N SER A 80 A 9 10 N LYS A 81 ? N LYS A 81 O GLN A 453 ? O GLN A 453 B 1 2 N SER A 359 ? N SER A 359 O ALA A 433 ? O ALA A 433 C 1 2 N SER A 363 ? N SER A 363 O LEU A 392 ? O LEU A 392 # loop_ _struct_site.id _struct_site.pdbx_evidence_code _struct_site.pdbx_auth_asym_id _struct_site.pdbx_auth_comp_id _struct_site.pdbx_auth_seq_id _struct_site.pdbx_auth_ins_code _struct_site.pdbx_num_residues _struct_site.details AC1 Software ? ? ? ? 11 'BINDING SITE FOR RESIDUE NAG A 801' AC2 Software ? ? ? ? 8 'BINDING SITE FOR RESIDUE NAG A 803' AC3 Software ? ? ? ? 4 'BINDING SITE FOR RESIDUE ZN A 901' AC4 Software ? ? ? ? 5 'BINDING SITE FOR RESIDUE ZN A 902' AC5 Software ? ? ? ? 6 'BINDING SITE FOR RESIDUE MG A 903' AC6 Software ? ? ? ? 5 'BINDING SITE FOR RESIDUE CA A 904' # loop_ _struct_site_gen.id _struct_site_gen.site_id _struct_site_gen.pdbx_num_res _struct_site_gen.label_comp_id _struct_site_gen.label_asym_id _struct_site_gen.label_seq_id _struct_site_gen.pdbx_auth_ins_code _struct_site_gen.auth_comp_id _struct_site_gen.auth_asym_id _struct_site_gen.auth_seq_id _struct_site_gen.label_atom_id _struct_site_gen.label_alt_id _struct_site_gen.symmetry _struct_site_gen.details 1 AC1 11 ASN A 122 ? ASN A 122 . ? 1_555 ? 2 AC1 11 LEU A 258 ? LEU A 258 . ? 8_455 ? 3 AC1 11 ARG A 297 ? ARG A 297 . ? 8_455 ? 4 AC1 11 ARG A 301 ? ARG A 301 . ? 8_455 ? 5 AC1 11 HOH H . ? HOH A 991 . ? 1_555 ? 6 AC1 11 HOH H . ? HOH A 1223 . ? 1_555 ? 7 AC1 11 HOH H . ? HOH A 1384 . ? 1_555 ? 8 AC1 11 HOH H . ? HOH A 1389 . ? 8_455 ? 9 AC1 11 HOH H . ? HOH A 1417 . ? 1_555 ? 10 AC1 11 HOH H . ? HOH A 1481 . ? 1_555 ? 11 AC1 11 HOH H . ? HOH A 1551 . ? 1_555 ? 12 AC2 8 TRP A 248 ? TRP A 248 . ? 1_555 ? 13 AC2 8 ASN A 249 ? ASN A 249 . ? 1_555 ? 14 AC2 8 GLU A 252 ? GLU A 252 . ? 1_555 ? 15 AC2 8 HOH H . ? HOH A 1056 . ? 1_555 ? 16 AC2 8 HOH H . ? HOH A 1287 . ? 1_555 ? 17 AC2 8 HOH H . ? HOH A 1291 . ? 1_555 ? 18 AC2 8 HOH H . ? HOH A 1303 . ? 1_555 ? 19 AC2 8 HOH H . ? HOH A 1403 . ? 1_555 ? 20 AC3 4 SEP A 92 ? SEP A 92 . ? 1_555 ? 21 AC3 4 ASP A 316 ? ASP A 316 . ? 1_555 ? 22 AC3 4 HIS A 320 ? HIS A 320 . ? 1_555 ? 23 AC3 4 HIS A 432 ? HIS A 432 . ? 1_555 ? 24 AC4 5 ASP A 42 ? ASP A 42 . ? 1_555 ? 25 AC4 5 SEP A 92 ? SEP A 92 . ? 1_555 ? 26 AC4 5 ASP A 316 ? ASP A 316 . ? 1_555 ? 27 AC4 5 ASP A 357 ? ASP A 357 . ? 1_555 ? 28 AC4 5 HIS A 358 ? HIS A 358 . ? 1_555 ? 29 AC5 6 ASP A 42 ? ASP A 42 . ? 1_555 ? 30 AC5 6 SER A 155 ? SER A 155 . ? 1_555 ? 31 AC5 6 GLU A 311 ? GLU A 311 . ? 1_555 ? 32 AC5 6 HOH H . ? HOH A 910 . ? 1_555 ? 33 AC5 6 HOH H . ? HOH A 927 . ? 1_555 ? 34 AC5 6 HOH H . ? HOH A 937 . ? 1_555 ? 35 AC6 5 GLU A 216 ? GLU A 216 . ? 1_555 ? 36 AC6 5 PHE A 269 ? PHE A 269 . ? 1_555 ? 37 AC6 5 GLU A 270 ? GLU A 270 . ? 1_555 ? 38 AC6 5 ASP A 285 ? ASP A 285 . ? 1_555 ? 39 AC6 5 HOH H . ? HOH A 995 . ? 1_555 ? # _database_PDB_matrix.entry_id 1ZEB _database_PDB_matrix.origx[1][1] 1.000000 _database_PDB_matrix.origx[1][2] 0.000000 _database_PDB_matrix.origx[1][3] 0.000000 _database_PDB_matrix.origx[2][1] 0.000000 _database_PDB_matrix.origx[2][2] 1.000000 _database_PDB_matrix.origx[2][3] 0.000000 _database_PDB_matrix.origx[3][1] 0.000000 _database_PDB_matrix.origx[3][2] 0.000000 _database_PDB_matrix.origx[3][3] 1.000000 _database_PDB_matrix.origx_vector[1] 0.00000 _database_PDB_matrix.origx_vector[2] 0.00000 _database_PDB_matrix.origx_vector[3] 0.00000 # _atom_sites.entry_id 1ZEB _atom_sites.fract_transf_matrix[1][1] 0.011233 _atom_sites.fract_transf_matrix[1][2] 0.000000 _atom_sites.fract_transf_matrix[1][3] 0.000000 _atom_sites.fract_transf_matrix[2][1] 0.000000 _atom_sites.fract_transf_matrix[2][2] 0.008780 _atom_sites.fract_transf_matrix[2][3] 0.000000 _atom_sites.fract_transf_matrix[3][1] 0.000000 _atom_sites.fract_transf_matrix[3][2] 0.000000 _atom_sites.fract_transf_matrix[3][3] 0.009381 _atom_sites.fract_transf_vector[1] 0.00000 _atom_sites.fract_transf_vector[2] 0.00000 _atom_sites.fract_transf_vector[3] 0.00000 # loop_ _atom_type.symbol C CA MG N O P S ZN # loop_ _atom_site.group_PDB _atom_site.id _atom_site.type_symbol _atom_site.label_atom_id _atom_site.label_alt_id _atom_site.label_comp_id _atom_site.label_asym_id _atom_site.label_entity_id _atom_site.label_seq_id _atom_site.pdbx_PDB_ins_code _atom_site.Cartn_x _atom_site.Cartn_y _atom_site.Cartn_z _atom_site.occupancy _atom_site.B_iso_or_equiv _atom_site.pdbx_formal_charge _atom_site.auth_seq_id _atom_site.auth_comp_id _atom_site.auth_asym_id _atom_site.auth_atom_id _atom_site.pdbx_PDB_model_num ATOM 1 N N . ILE A 1 1 ? 68.360 15.644 30.965 1.00 22.55 ? 1 ILE A N 1 ATOM 2 C CA . ILE A 1 1 ? 69.561 16.526 31.101 1.00 22.46 ? 1 ILE A CA 1 ATOM 3 C C . ILE A 1 1 ? 69.195 17.885 31.705 1.00 22.20 ? 1 ILE A C 1 ATOM 4 O O . ILE A 1 1 ? 68.284 18.561 31.212 1.00 21.70 ? 1 ILE A O 1 ATOM 5 C CB . ILE A 1 1 ? 70.223 16.719 29.741 1.00 22.99 ? 1 ILE A CB 1 ATOM 6 N N . ILE A 1 2 ? 69.913 18.291 32.749 1.00 21.84 ? 2 ILE A N 1 ATOM 7 C CA . ILE A 1 2 ? 69.679 19.592 33.389 1.00 21.52 ? 2 ILE A CA 1 ATOM 8 C C . ILE A 1 2 ? 70.582 20.664 32.767 1.00 22.01 ? 2 ILE A C 1 ATOM 9 O O . ILE A 1 2 ? 71.796 20.639 32.993 1.00 22.59 ? 2 ILE A O 1 ATOM 10 C CB . ILE A 1 2 ? 69.937 19.510 34.919 1.00 21.92 ? 2 ILE A CB 1 ATOM 11 C CG1 . ILE A 1 2 ? 68.930 18.576 35.592 1.00 21.40 ? 2 ILE A CG1 1 ATOM 12 C CG2 . ILE A 1 2 ? 69.888 20.917 35.564 1.00 21.75 ? 2 ILE A CG2 1 ATOM 13 C CD1 . ILE A 1 2 ? 69.325 18.157 37.012 1.00 21.50 ? 2 ILE A CD1 1 ATOM 14 N N . PRO A 1 3 ? 70.013 21.607 32.008 1.00 21.83 ? 3 PRO A N 1 ATOM 15 C CA . PRO A 1 3 ? 70.799 22.685 31.421 1.00 22.09 ? 3 PRO A CA 1 ATOM 16 C C . PRO A 1 3 ? 71.364 23.571 32.515 1.00 22.09 ? 3 PRO A C 1 ATOM 17 O O . PRO A 1 3 ? 70.620 24.094 33.343 1.00 22.17 ? 3 PRO A O 1 ATOM 18 C CB . PRO A 1 3 ? 69.782 23.448 30.565 1.00 21.90 ? 3 PRO A CB 1 ATOM 19 C CG . PRO A 1 3 ? 68.483 23.112 31.157 1.00 21.96 ? 3 PRO A CG 1 ATOM 20 C CD . PRO A 1 3 ? 68.591 21.709 31.631 1.00 21.99 ? 3 PRO A CD 1 ATOM 21 N N . VAL A 1 4 ? 72.682 23.715 32.520 1.00 22.63 ? 4 VAL A N 1 ATOM 22 C CA . VAL A 1 4 ? 73.378 24.373 33.616 1.00 22.33 ? 4 VAL A CA 1 ATOM 23 C C . VAL A 1 4 ? 72.845 25.774 33.853 1.00 21.82 ? 4 VAL A C 1 ATOM 24 O O . VAL A 1 4 ? 72.625 26.172 34.997 1.00 20.75 ? 4 VAL A O 1 ATOM 25 C CB . VAL A 1 4 ? 74.902 24.468 33.361 1.00 22.85 ? 4 VAL A CB 1 ATOM 26 C CG1 . VAL A 1 4 ? 75.607 24.843 34.632 1.00 23.69 ? 4 VAL A CG1 1 ATOM 27 C CG2 . VAL A 1 4 ? 75.459 23.146 32.840 1.00 23.72 ? 4 VAL A CG2 1 ATOM 28 N N . GLU A 1 5 ? 72.627 26.512 32.769 1.00 21.53 ? 5 GLU A N 1 ATOM 29 C CA . GLU A 1 5 ? 72.120 27.885 32.853 1.00 22.13 ? 5 GLU A CA 1 ATOM 30 C C . GLU A 1 5 ? 70.813 28.025 33.637 1.00 20.55 ? 5 GLU A C 1 ATOM 31 O O . GLU A 1 5 ? 70.579 29.054 34.264 1.00 19.39 ? 5 GLU A O 1 ATOM 32 C CB . GLU A 1 5 ? 71.936 28.478 31.456 1.00 22.48 ? 5 GLU A CB 1 ATOM 33 C CG . GLU A 1 5 ? 70.782 27.872 30.667 1.00 24.95 ? 5 GLU A CG 1 ATOM 34 C CD . GLU A 1 5 ? 70.868 28.168 29.185 1.00 25.69 ? 5 GLU A CD 1 ATOM 35 O OE1 . GLU A 1 5 ? 69.827 28.108 28.498 1.00 29.40 ? 5 GLU A OE1 1 ATOM 36 O OE2 . GLU A 1 5 ? 71.985 28.476 28.700 1.00 33.91 ? 5 GLU A OE2 1 ATOM 37 N N . GLU A 1 6 ? 69.977 26.991 33.607 1.00 19.67 ? 6 GLU A N 1 ATOM 38 C CA . GLU A 1 6 ? 68.671 27.039 34.269 1.00 19.29 ? 6 GLU A CA 1 ATOM 39 C C . GLU A 1 6 ? 68.748 26.775 35.771 1.00 18.73 ? 6 GLU A C 1 ATOM 40 O O . GLU A 1 6 ? 67.781 26.991 36.487 1.00 18.16 ? 6 GLU A O 1 ATOM 41 C CB . GLU A 1 6 ? 67.706 26.072 33.598 1.00 19.16 ? 6 GLU A CB 1 ATOM 42 C CG . GLU A 1 6 ? 67.393 26.489 32.170 1.00 18.60 ? 6 GLU A CG 1 ATOM 43 C CD . GLU A 1 6 ? 66.387 25.591 31.471 1.00 19.59 ? 6 GLU A CD 1 ATOM 44 O OE1 . GLU A 1 6 ? 66.177 25.784 30.239 1.00 19.01 ? 6 GLU A OE1 1 ATOM 45 O OE2 . GLU A 1 6 ? 65.807 24.707 32.139 1.00 16.72 ? 6 GLU A OE2 1 ATOM 46 N N . GLU A 1 7 ? 69.907 26.327 36.246 1.00 18.21 ? 7 GLU A N 1 ATOM 47 C CA . GLU A 1 7 ? 70.118 26.106 37.677 1.00 17.95 ? 7 GLU A CA 1 ATOM 48 C C . GLU A 1 7 ? 70.219 27.398 38.458 1.00 17.65 ? 7 GLU A C 1 ATOM 49 O O . GLU A 1 7 ? 70.084 27.403 39.674 1.00 16.56 ? 7 GLU A O 1 ATOM 50 C CB . GLU A 1 7 ? 71.380 25.287 37.910 1.00 18.06 ? 7 GLU A CB 1 ATOM 51 C CG . GLU A 1 7 ? 71.349 23.927 37.251 1.00 19.61 ? 7 GLU A CG 1 ATOM 52 C CD . GLU A 1 7 ? 72.485 23.033 37.716 1.00 24.03 ? 7 GLU A CD 1 ATOM 53 O OE1 . GLU A 1 7 ? 72.758 22.042 37.052 1.00 25.93 ? 7 GLU A OE1 1 ATOM 54 O OE2 . GLU A 1 7 ? 73.114 23.328 38.745 1.00 28.39 ? 7 GLU A OE2 1 ATOM 55 N N . ASN A 1 8 ? 70.483 28.490 37.753 1.00 18.24 ? 8 ASN A N 1 ATOM 56 C CA . ASN A 1 8 ? 70.588 29.805 38.362 1.00 18.33 ? 8 ASN A CA 1 ATOM 57 C C . ASN A 1 8 ? 69.207 30.472 38.328 1.00 18.45 ? 8 ASN A C 1 ATOM 58 O O . ASN A 1 8 ? 68.658 30.645 37.245 1.00 18.02 ? 8 ASN A O 1 ATOM 59 C CB . ASN A 1 8 ? 71.611 30.632 37.563 1.00 18.31 ? 8 ASN A CB 1 ATOM 60 C CG . ASN A 1 8 ? 71.960 31.950 38.220 1.00 19.07 ? 8 ASN A CG 1 ATOM 61 O OD1 . ASN A 1 8 ? 72.956 32.594 37.857 1.00 22.63 ? 8 ASN A OD1 1 ATOM 62 N ND2 . ASN A 1 8 ? 71.173 32.355 39.196 1.00 17.24 ? 8 ASN A ND2 1 ATOM 63 N N . PRO A 1 9 ? 68.645 30.853 39.483 1.00 18.82 ? 9 PRO A N 1 ATOM 64 C CA . PRO A 1 9 ? 67.356 31.549 39.520 1.00 19.25 ? 9 PRO A CA 1 ATOM 65 C C . PRO A 1 9 ? 67.293 32.804 38.658 1.00 19.56 ? 9 PRO A C 1 ATOM 66 O O . PRO A 1 9 ? 66.216 33.141 38.164 1.00 18.61 ? 9 PRO A O 1 ATOM 67 C CB . PRO A 1 9 ? 67.195 31.941 40.990 1.00 19.70 ? 9 PRO A CB 1 ATOM 68 C CG . PRO A 1 9 ? 68.094 31.065 41.746 1.00 20.01 ? 9 PRO A CG 1 ATOM 69 C CD . PRO A 1 9 ? 69.185 30.642 40.836 1.00 19.24 ? 9 PRO A CD 1 ATOM 70 N N . ASP A 1 10 ? 68.420 33.496 38.461 1.00 20.02 ? 10 ASP A N 1 ATOM 71 C CA . ASP A 1 10 ? 68.379 34.702 37.638 1.00 21.06 ? 10 ASP A CA 1 ATOM 72 C C . ASP A 1 10 ? 68.021 34.403 36.204 1.00 19.93 ? 10 ASP A C 1 ATOM 73 O O . ASP A 1 10 ? 67.503 35.271 35.510 1.00 20.09 ? 10 ASP A O 1 ATOM 74 C CB . ASP A 1 10 ? 69.674 35.497 37.647 1.00 21.84 ? 10 ASP A CB 1 ATOM 75 C CG . ASP A 1 10 ? 69.456 36.960 37.200 1.00 26.74 ? 10 ASP A CG 1 ATOM 76 O OD1 . ASP A 1 10 ? 68.447 37.582 37.651 1.00 29.40 ? 10 ASP A OD1 1 ATOM 77 O OD2 . ASP A 1 10 ? 70.228 37.553 36.395 1.00 32.36 ? 10 ASP A OD2 1 ATOM 78 N N . PHE A 1 11 ? 68.314 33.193 35.747 1.00 19.19 ? 11 PHE A N 1 ATOM 79 C CA . PHE A 1 11 ? 67.879 32.790 34.408 1.00 18.82 ? 11 PHE A CA 1 ATOM 80 C C . PHE A 1 11 ? 66.360 32.977 34.259 1.00 18.01 ? 11 PHE A C 1 ATOM 81 O O . PHE A 1 11 ? 65.873 33.583 33.288 1.00 16.57 ? 11 PHE A O 1 ATOM 82 C CB . PHE A 1 11 ? 68.240 31.337 34.134 1.00 19.60 ? 11 PHE A CB 1 ATOM 83 C CG . PHE A 1 11 ? 67.757 30.845 32.802 1.00 20.23 ? 11 PHE A CG 1 ATOM 84 C CD1 . PHE A 1 11 ? 68.538 31.001 31.665 1.00 22.22 ? 11 PHE A CD1 1 ATOM 85 C CD2 . PHE A 1 11 ? 66.516 30.227 32.684 1.00 20.67 ? 11 PHE A CD2 1 ATOM 86 C CE1 . PHE A 1 11 ? 68.090 30.542 30.423 1.00 22.36 ? 11 PHE A CE1 1 ATOM 87 C CE2 . PHE A 1 11 ? 66.056 29.775 31.461 1.00 21.46 ? 11 PHE A CE2 1 ATOM 88 C CZ . PHE A 1 11 ? 66.843 29.926 30.324 1.00 21.95 ? 11 PHE A CZ 1 ATOM 89 N N . TRP A 1 12 ? 65.640 32.458 35.249 1.00 17.42 ? 12 TRP A N 1 ATOM 90 C CA . TRP A 1 12 ? 64.183 32.502 35.288 1.00 17.32 ? 12 TRP A CA 1 ATOM 91 C C . TRP A 1 12 ? 63.706 33.919 35.627 1.00 17.65 ? 12 TRP A C 1 ATOM 92 O O . TRP A 1 12 ? 62.763 34.439 35.035 1.00 17.28 ? 12 TRP A O 1 ATOM 93 C CB . TRP A 1 12 ? 63.679 31.456 36.292 1.00 17.00 ? 12 TRP A CB 1 ATOM 94 C CG . TRP A 1 12 ? 64.140 30.107 35.890 1.00 16.92 ? 12 TRP A CG 1 ATOM 95 C CD1 . TRP A 1 12 ? 65.172 29.390 36.424 1.00 17.68 ? 12 TRP A CD1 1 ATOM 96 C CD2 . TRP A 1 12 ? 63.655 29.349 34.791 1.00 16.20 ? 12 TRP A CD2 1 ATOM 97 N NE1 . TRP A 1 12 ? 65.338 28.211 35.739 1.00 17.22 ? 12 TRP A NE1 1 ATOM 98 C CE2 . TRP A 1 12 ? 64.414 28.162 34.727 1.00 17.71 ? 12 TRP A CE2 1 ATOM 99 C CE3 . TRP A 1 12 ? 62.639 29.541 33.854 1.00 16.88 ? 12 TRP A CE3 1 ATOM 100 C CZ2 . TRP A 1 12 ? 64.179 27.180 33.777 1.00 16.46 ? 12 TRP A CZ2 1 ATOM 101 C CZ3 . TRP A 1 12 ? 62.413 28.562 32.907 1.00 16.71 ? 12 TRP A CZ3 1 ATOM 102 C CH2 . TRP A 1 12 ? 63.184 27.400 32.875 1.00 16.24 ? 12 TRP A CH2 1 ATOM 103 N N . ASN A 1 13 ? 64.385 34.572 36.558 1.00 17.86 ? 13 ASN A N 1 ATOM 104 C CA . ASN A 1 13 ? 63.991 35.923 36.915 1.00 18.33 ? 13 ASN A CA 1 ATOM 105 C C . ASN A 1 13 ? 64.164 36.884 35.742 1.00 18.67 ? 13 ASN A C 1 ATOM 106 O O . ASN A 1 13 ? 63.301 37.719 35.507 1.00 18.46 ? 13 ASN A O 1 ATOM 107 C CB . ASN A 1 13 ? 64.726 36.388 38.167 1.00 18.85 ? 13 ASN A CB 1 ATOM 108 C CG . ASN A 1 13 ? 64.280 35.631 39.407 1.00 19.21 ? 13 ASN A CG 1 ATOM 109 O OD1 . ASN A 1 13 ? 63.140 35.170 39.487 1.00 20.76 ? 13 ASN A OD1 1 ATOM 110 N ND2 . ASN A 1 13 ? 65.177 35.488 40.377 1.00 18.25 ? 13 ASN A ND2 1 ATOM 111 N N . ARG A 1 14 ? 65.255 36.725 34.989 1.00 19.07 ? 14 ARG A N 1 ATOM 112 C CA . ARG A 1 14 ? 65.509 37.541 33.800 1.00 20.05 ? 14 ARG A CA 1 ATOM 113 C C . ARG A 1 14 ? 64.423 37.344 32.737 1.00 18.68 ? 14 ARG A C 1 ATOM 114 O O . ARG A 1 14 ? 63.898 38.316 32.177 1.00 17.63 ? 14 ARG A O 1 ATOM 115 C CB . ARG A 1 14 ? 66.887 37.189 33.213 1.00 20.13 ? 14 ARG A CB 1 ATOM 116 C CG . ARG A 1 14 ? 67.278 37.987 31.959 1.00 22.69 ? 14 ARG A CG 1 ATOM 117 C CD . ARG A 1 14 ? 68.666 37.620 31.399 1.00 24.43 ? 14 ARG A CD 1 ATOM 118 N NE . ARG A 1 14 ? 69.599 37.287 32.482 1.00 28.66 ? 14 ARG A NE 1 ATOM 119 C CZ . ARG A 1 14 ? 70.014 36.051 32.790 1.00 30.91 ? 14 ARG A CZ 1 ATOM 120 N NH1 . ARG A 1 14 ? 70.841 35.881 33.813 1.00 32.05 ? 14 ARG A NH1 1 ATOM 121 N NH2 . ARG A 1 14 ? 69.644 34.991 32.069 1.00 34.16 ? 14 ARG A NH2 1 ATOM 122 N N . GLU A 1 15 ? 64.105 36.086 32.461 1.00 18.01 ? 15 GLU A N 1 ATOM 123 C CA . GLU A 1 15 ? 63.123 35.728 31.446 1.00 18.23 ? 15 GLU A CA 1 ATOM 124 C C . GLU A 1 15 ? 61.757 36.316 31.802 1.00 17.67 ? 15 GLU A C 1 ATOM 125 O O . GLU A 1 15 ? 61.084 36.902 30.964 1.00 16.98 ? 15 GLU A O 1 ATOM 126 C CB . GLU A 1 15 ? 63.015 34.199 31.336 1.00 18.89 ? 15 GLU A CB 1 ATOM 127 C CG . GLU A 1 15 ? 62.145 33.698 30.179 1.00 20.53 ? 15 GLU A CG 1 ATOM 128 C CD . GLU A 1 15 ? 60.649 33.760 30.428 1.00 24.21 ? 15 GLU A CD 1 ATOM 129 O OE1 . GLU A 1 15 ? 60.217 33.720 31.615 1.00 27.17 ? 15 GLU A OE1 1 ATOM 130 O OE2 . GLU A 1 15 ? 59.884 33.825 29.420 1.00 27.01 ? 15 GLU A OE2 1 ATOM 131 N N . ALA A 1 16 ? 61.367 36.169 33.063 1.00 17.44 ? 16 ALA A N 1 ATOM 132 C CA . ALA A 1 16 ? 60.054 36.619 33.519 1.00 16.86 ? 16 ALA A CA 1 ATOM 133 C C . ALA A 1 16 ? 59.991 38.147 33.550 1.00 17.14 ? 16 ALA A C 1 ATOM 134 O O . ALA A 1 16 ? 58.984 38.744 33.169 1.00 15.68 ? 16 ALA A O 1 ATOM 135 C CB . ALA A 1 16 ? 59.724 36.019 34.888 1.00 17.39 ? 16 ALA A CB 1 ATOM 136 N N . ALA A 1 17 ? 61.074 38.783 33.983 1.00 17.76 ? 17 ALA A N 1 ATOM 137 C CA . ALA A 1 17 ? 61.168 40.228 33.872 1.00 18.23 ? 17 ALA A CA 1 ATOM 138 C C . ALA A 1 17 ? 60.995 40.654 32.411 1.00 18.62 ? 17 ALA A C 1 ATOM 139 O O . ALA A 1 17 ? 60.263 41.603 32.123 1.00 18.46 ? 17 ALA A O 1 ATOM 140 C CB . ALA A 1 17 ? 62.484 40.729 34.438 1.00 18.66 ? 17 ALA A CB 1 ATOM 141 N N . GLU A 1 18 ? 61.629 39.937 31.483 1.00 19.55 ? 18 GLU A N 1 ATOM 142 C CA . GLU A 1 18 ? 61.471 40.228 30.041 1.00 20.71 ? 18 GLU A CA 1 ATOM 143 C C . GLU A 1 18 ? 60.029 39.996 29.576 1.00 19.72 ? 18 GLU A C 1 ATOM 144 O O . GLU A 1 18 ? 59.473 40.771 28.787 1.00 18.74 ? 18 GLU A O 1 ATOM 145 C CB . GLU A 1 18 ? 62.421 39.380 29.200 1.00 20.76 ? 18 GLU A CB 1 ATOM 146 C CG . GLU A 1 18 ? 63.883 39.778 29.324 1.00 23.43 ? 18 GLU A CG 1 ATOM 147 C CD . GLU A 1 18 ? 64.852 38.686 28.903 1.00 24.85 ? 18 GLU A CD 1 ATOM 148 O OE1 . GLU A 1 18 ? 64.399 37.579 28.508 1.00 30.56 ? 18 GLU A OE1 1 ATOM 149 O OE2 . GLU A 1 18 ? 66.081 38.936 28.963 1.00 30.76 ? 18 GLU A OE2 1 ATOM 150 N N . ALA A 1 19 ? 59.437 38.909 30.059 1.00 19.55 ? 19 ALA A N 1 ATOM 151 C CA . ALA A 1 19 ? 58.042 38.604 29.776 1.00 19.10 ? 19 ALA A CA 1 ATOM 152 C C . ALA A 1 19 ? 57.105 39.719 30.269 1.00 18.90 ? 19 ALA A C 1 ATOM 153 O O . ALA A 1 19 ? 56.223 40.149 29.525 1.00 18.95 ? 19 ALA A O 1 ATOM 154 C CB . ALA A 1 19 ? 57.652 37.256 30.385 1.00 19.29 ? 19 ALA A CB 1 ATOM 155 N N . LEU A 1 20 ? 57.305 40.201 31.497 1.00 18.83 ? 20 LEU A N 1 ATOM 156 C CA . LEU A 1 20 ? 56.488 41.300 32.019 1.00 19.03 ? 20 LEU A CA 1 ATOM 157 C C . LEU A 1 20 ? 56.646 42.587 31.209 1.00 18.90 ? 20 LEU A C 1 ATOM 158 O O . LEU A 1 20 ? 55.674 43.300 30.977 1.00 19.14 ? 20 LEU A O 1 ATOM 159 C CB . LEU A 1 20 ? 56.801 41.585 33.488 1.00 19.13 ? 20 LEU A CB 1 ATOM 160 C CG . LEU A 1 20 ? 56.300 40.556 34.502 1.00 19.16 ? 20 LEU A CG 1 ATOM 161 C CD1 . LEU A 1 20 ? 56.890 40.843 35.861 1.00 20.05 ? 20 LEU A CD1 1 ATOM 162 C CD2 . LEU A 1 20 ? 54.773 40.540 34.568 1.00 20.44 ? 20 LEU A CD2 1 ATOM 163 N N . GLY A 1 21 ? 57.869 42.876 30.776 1.00 19.43 ? 21 GLY A N 1 ATOM 164 C CA . GLY A 1 21 ? 58.126 44.072 29.987 1.00 19.58 ? 21 GLY A CA 1 ATOM 165 C C . GLY A 1 21 ? 57.313 44.024 28.706 1.00 19.93 ? 21 GLY A C 1 ATOM 166 O O . GLY A 1 21 ? 56.637 44.999 28.344 1.00 20.64 ? 21 GLY A O 1 ATOM 167 N N . ALA A 1 22 ? 57.347 42.870 28.048 1.00 20.04 ? 22 ALA A N 1 ATOM 168 C CA . ALA A 1 22 ? 56.647 42.663 26.781 1.00 20.21 ? 22 ALA A CA 1 ATOM 169 C C . ALA A 1 22 ? 55.142 42.705 26.971 1.00 20.44 ? 22 ALA A C 1 ATOM 170 O O . ALA A 1 22 ? 54.415 43.247 26.135 1.00 20.27 ? 22 ALA A O 1 ATOM 171 C CB . ALA A 1 22 ? 57.062 41.342 26.179 1.00 20.33 ? 22 ALA A CB 1 ATOM 172 N N . ALA A 1 23 ? 54.680 42.142 28.083 1.00 20.49 ? 23 ALA A N 1 ATOM 173 C CA . ALA A 1 23 ? 53.257 42.123 28.409 1.00 20.98 ? 23 ALA A CA 1 ATOM 174 C C . ALA A 1 23 ? 52.747 43.541 28.590 1.00 21.60 ? 23 ALA A C 1 ATOM 175 O O . ALA A 1 23 ? 51.656 43.884 28.148 1.00 22.08 ? 23 ALA A O 1 ATOM 176 C CB . ALA A 1 23 ? 53.018 41.313 29.666 1.00 20.20 ? 23 ALA A CB 1 ATOM 177 N N . LYS A 1 24 ? 53.564 44.367 29.229 1.00 22.76 ? 24 LYS A N 1 ATOM 178 C CA . LYS A 1 24 ? 53.201 45.751 29.494 1.00 23.93 ? 24 LYS A CA 1 ATOM 179 C C . LYS A 1 24 ? 53.193 46.610 28.239 1.00 24.52 ? 24 LYS A C 1 ATOM 180 O O . LYS A 1 24 ? 52.504 47.616 28.199 1.00 24.72 ? 24 LYS A O 1 ATOM 181 C CB . LYS A 1 24 ? 54.152 46.348 30.529 1.00 24.06 ? 24 LYS A CB 1 ATOM 182 C CG . LYS A 1 24 ? 53.971 45.740 31.902 1.00 25.82 ? 24 LYS A CG 1 ATOM 183 C CD . LYS A 1 24 ? 55.205 45.915 32.769 1.00 28.71 ? 24 LYS A CD 1 ATOM 184 C CE . LYS A 1 24 ? 55.285 47.314 33.311 1.00 30.64 ? 24 LYS A CE 1 ATOM 185 N NZ . LYS A 1 24 ? 56.663 47.660 33.771 1.00 34.41 ? 24 LYS A NZ 1 ATOM 186 N N . LYS A 1 25 ? 53.950 46.223 27.220 1.00 25.63 ? 25 LYS A N 1 ATOM 187 C CA . LYS A 1 25 ? 54.055 47.032 26.002 1.00 27.06 ? 25 LYS A CA 1 ATOM 188 C C . LYS A 1 25 ? 52.860 46.829 25.072 1.00 27.49 ? 25 LYS A C 1 ATOM 189 O O . LYS A 1 25 ? 52.554 47.700 24.260 1.00 27.61 ? 25 LYS A O 1 ATOM 190 C CB . LYS A 1 25 ? 55.374 46.753 25.277 1.00 27.22 ? 25 LYS A CB 1 ATOM 191 C CG . LYS A 1 25 ? 56.565 47.182 26.106 1.00 28.54 ? 25 LYS A CG 1 ATOM 192 C CD . LYS A 1 25 ? 57.895 47.071 25.392 1.00 29.22 ? 25 LYS A CD 1 ATOM 193 C CE . LYS A 1 25 ? 59.038 47.340 26.388 1.00 31.38 ? 25 LYS A CE 1 ATOM 194 N NZ . LYS A 1 25 ? 60.406 47.325 25.780 1.00 32.76 ? 25 LYS A NZ 1 ATOM 195 N N . LEU A 1 26 ? 52.183 45.687 25.212 1.00 27.95 ? 26 LEU A N 1 ATOM 196 C CA . LEU A 1 26 ? 50.977 45.380 24.441 1.00 28.43 ? 26 LEU A CA 1 ATOM 197 C C . LEU A 1 26 ? 49.914 46.486 24.529 1.00 28.67 ? 26 LEU A C 1 ATOM 198 O O . LEU A 1 26 ? 49.517 46.890 25.627 1.00 27.96 ? 26 LEU A O 1 ATOM 199 C CB . LEU A 1 26 ? 50.376 44.048 24.914 1.00 28.50 ? 26 LEU A CB 1 ATOM 200 C CG . LEU A 1 26 ? 50.670 42.730 24.182 1.00 29.34 ? 26 LEU A CG 1 ATOM 201 C CD1 . LEU A 1 26 ? 51.911 42.733 23.298 1.00 30.36 ? 26 LEU A CD1 1 ATOM 202 C CD2 . LEU A 1 26 ? 50.704 41.587 25.165 1.00 28.17 ? 26 LEU A CD2 1 ATOM 203 N N . GLN A 1 27 ? 49.466 46.951 23.362 1.00 29.24 ? 27 GLN A N 1 ATOM 204 C CA . GLN A 1 27 ? 48.418 47.968 23.242 1.00 30.44 ? 27 GLN A CA 1 ATOM 205 C C . GLN A 1 27 ? 47.392 47.557 22.184 1.00 29.84 ? 27 GLN A C 1 ATOM 206 O O . GLN A 1 27 ? 47.759 46.990 21.162 1.00 30.16 ? 27 GLN A O 1 ATOM 207 C CB . GLN A 1 27 ? 49.032 49.298 22.817 1.00 30.48 ? 27 GLN A CB 1 ATOM 208 C CG . GLN A 1 27 ? 49.817 50.014 23.906 1.00 32.66 ? 27 GLN A CG 1 ATOM 209 C CD . GLN A 1 27 ? 50.470 51.295 23.400 1.00 33.01 ? 27 GLN A CD 1 ATOM 210 O OE1 . GLN A 1 27 ? 50.166 51.756 22.291 1.00 37.35 ? 27 GLN A OE1 1 ATOM 211 N NE2 . GLN A 1 27 ? 51.374 51.868 24.203 1.00 36.34 ? 27 GLN A NE2 1 ATOM 212 N N . PRO A 1 28 ? 46.118 47.868 22.395 1.00 29.81 ? 28 PRO A N 1 ATOM 213 C CA . PRO A 1 28 ? 45.092 47.548 21.400 1.00 29.35 ? 28 PRO A CA 1 ATOM 214 C C . PRO A 1 28 ? 45.190 48.470 20.196 1.00 28.92 ? 28 PRO A C 1 ATOM 215 O O . PRO A 1 28 ? 45.506 49.651 20.358 1.00 28.40 ? 28 PRO A O 1 ATOM 216 C CB . PRO A 1 28 ? 43.783 47.808 22.151 1.00 29.71 ? 28 PRO A CB 1 ATOM 217 C CG . PRO A 1 28 ? 44.124 48.813 23.199 1.00 29.92 ? 28 PRO A CG 1 ATOM 218 C CD . PRO A 1 28 ? 45.553 48.561 23.569 1.00 30.04 ? 28 PRO A CD 1 ATOM 219 N N . ALA A 1 29 ? 44.943 47.938 19.002 1.00 28.13 ? 29 ALA A N 1 ATOM 220 C CA . ALA A 1 29 ? 44.845 48.773 17.807 1.00 27.89 ? 29 ALA A CA 1 ATOM 221 C C . ALA A 1 29 ? 43.522 49.542 17.843 1.00 27.60 ? 29 ALA A C 1 ATOM 222 O O . ALA A 1 29 ? 42.531 49.052 18.365 1.00 27.11 ? 29 ALA A O 1 ATOM 223 C CB . ALA A 1 29 ? 44.915 47.927 16.552 1.00 27.72 ? 29 ALA A CB 1 ATOM 224 N N . GLN A 1 30 ? 43.522 50.745 17.283 1.00 27.69 ? 30 GLN A N 1 ATOM 225 C CA . GLN A 1 30 ? 42.284 51.488 17.036 1.00 28.12 ? 30 GLN A CA 1 ATOM 226 C C . GLN A 1 30 ? 41.877 51.377 15.560 1.00 26.30 ? 30 GLN A C 1 ATOM 227 O O . GLN A 1 30 ? 40.839 51.899 15.143 1.00 26.07 ? 30 GLN A O 1 ATOM 228 C CB . GLN A 1 30 ? 42.450 52.955 17.456 1.00 28.50 ? 30 GLN A CB 1 ATOM 229 C CG . GLN A 1 30 ? 42.081 53.207 18.923 1.00 30.89 ? 30 GLN A CG 1 ATOM 230 C CD . GLN A 1 30 ? 41.974 54.681 19.260 1.00 31.32 ? 30 GLN A CD 1 ATOM 231 O OE1 . GLN A 1 30 ? 42.989 55.337 19.523 1.00 34.80 ? 30 GLN A OE1 1 ATOM 232 N NE2 . GLN A 1 30 ? 40.742 55.203 19.276 1.00 34.56 ? 30 GLN A NE2 1 ATOM 233 N N . THR A 1 31 ? 42.685 50.653 14.788 1.00 24.95 ? 31 THR A N 1 ATOM 234 C CA . THR A 1 31 ? 42.506 50.535 13.348 1.00 23.64 ? 31 THR A CA 1 ATOM 235 C C . THR A 1 31 ? 41.992 49.147 12.979 1.00 22.44 ? 31 THR A C 1 ATOM 236 O O . THR A 1 31 ? 42.212 48.168 13.702 1.00 21.53 ? 31 THR A O 1 ATOM 237 C CB . THR A 1 31 ? 43.837 50.782 12.639 1.00 23.77 ? 31 THR A CB 1 ATOM 238 O OG1 . THR A 1 31 ? 44.865 49.989 13.255 1.00 23.24 ? 31 THR A OG1 1 ATOM 239 C CG2 . THR A 1 31 ? 44.308 52.237 12.826 1.00 23.87 ? 31 THR A CG2 1 ATOM 240 N N . ALA A 1 32 ? 41.321 49.077 11.835 1.00 20.94 ? 32 ALA A N 1 ATOM 241 C CA . ALA A 1 32 ? 40.765 47.828 11.341 1.00 20.14 ? 32 ALA A CA 1 ATOM 242 C C . ALA A 1 32 ? 41.849 46.964 10.691 1.00 19.55 ? 32 ALA A C 1 ATOM 243 O O . ALA A 1 32 ? 42.977 47.417 10.433 1.00 18.96 ? 32 ALA A O 1 ATOM 244 C CB . ALA A 1 32 ? 39.630 48.108 10.348 1.00 19.98 ? 32 ALA A CB 1 ATOM 245 N N . ALA A 1 33 ? 41.498 45.710 10.440 1.00 18.60 ? 33 ALA A N 1 ATOM 246 C CA . ALA A 1 33 ? 42.355 44.811 9.682 1.00 18.23 ? 33 ALA A CA 1 ATOM 247 C C . ALA A 1 33 ? 42.042 44.909 8.198 1.00 17.84 ? 33 ALA A C 1 ATOM 248 O O . ALA A 1 33 ? 40.892 44.722 7.768 1.00 17.80 ? 33 ALA A O 1 ATOM 249 C CB . ALA A 1 33 ? 42.162 43.389 10.146 1.00 18.50 ? 33 ALA A CB 1 ATOM 250 N N . LYS A 1 34 ? 43.075 45.198 7.417 1.00 17.22 ? 34 LYS A N 1 ATOM 251 C CA . LYS A 1 34 ? 42.996 45.102 5.964 1.00 16.66 ? 34 LYS A CA 1 ATOM 252 C C . LYS A 1 34 ? 42.886 43.636 5.547 1.00 16.14 ? 34 LYS A C 1 ATOM 253 O O . LYS A 1 34 ? 42.104 43.296 4.668 1.00 16.52 ? 34 LYS A O 1 ATOM 254 C CB . LYS A 1 34 ? 44.240 45.725 5.342 1.00 16.27 ? 34 LYS A CB 1 ATOM 255 C CG . LYS A 1 34 ? 44.326 45.676 3.798 1.00 16.66 ? 34 LYS A CG 1 ATOM 256 C CD . LYS A 1 34 ? 45.720 46.045 3.378 1.00 15.60 ? 34 LYS A CD 1 ATOM 257 C CE . LYS A 1 34 ? 45.940 46.005 1.888 1.00 16.14 ? 34 LYS A CE 1 ATOM 258 N NZ . LYS A 1 34 ? 47.379 46.321 1.564 1.00 15.60 ? 34 LYS A NZ 1 ATOM 259 N N . ASN A 1 35 ? 43.691 42.785 6.173 1.00 15.70 ? 35 ASN A N 1 ATOM 260 C CA . ASN A 1 35 ? 43.803 41.376 5.805 1.00 15.42 ? 35 ASN A CA 1 ATOM 261 C C . ASN A 1 35 ? 43.381 40.502 6.959 1.00 14.42 ? 35 ASN A C 1 ATOM 262 O O . ASN A 1 35 ? 43.544 40.890 8.105 1.00 14.17 ? 35 ASN A O 1 ATOM 263 C CB . ASN A 1 35 ? 45.249 41.027 5.458 1.00 15.18 ? 35 ASN A CB 1 ATOM 264 C CG . ASN A 1 35 ? 45.806 41.907 4.377 1.00 16.47 ? 35 ASN A CG 1 ATOM 265 O OD1 . ASN A 1 35 ? 45.137 42.173 3.376 1.00 17.88 ? 35 ASN A OD1 1 ATOM 266 N ND2 . ASN A 1 35 ? 47.024 42.400 4.587 1.00 15.49 ? 35 ASN A ND2 1 ATOM 267 N N . LEU A 1 36 ? 42.893 39.310 6.644 1.00 13.90 ? 36 LEU A N 1 ATOM 268 C CA . LEU A 1 36 ? 42.486 38.334 7.644 1.00 14.15 ? 36 LEU A CA 1 ATOM 269 C C . LEU A 1 36 ? 43.072 37.003 7.288 1.00 14.33 ? 36 LEU A C 1 ATOM 270 O O . LEU A 1 36 ? 42.943 36.555 6.154 1.00 14.51 ? 36 LEU A O 1 ATOM 271 C CB . LEU A 1 36 ? 40.983 38.181 7.672 1.00 14.47 ? 36 LEU A CB 1 ATOM 272 C CG . LEU A 1 36 ? 40.143 39.377 8.097 1.00 13.62 ? 36 LEU A CG 1 ATOM 273 C CD1 . LEU A 1 36 ? 38.695 39.016 7.862 1.00 14.00 ? 36 LEU A CD1 1 ATOM 274 C CD2 . LEU A 1 36 ? 40.390 39.745 9.557 1.00 16.22 ? 36 LEU A CD2 1 ATOM 275 N N . ILE A 1 37 ? 43.717 36.371 8.251 1.00 14.03 ? 37 ILE A N 1 ATOM 276 C CA . ILE A 1 37 ? 44.213 35.008 8.044 1.00 13.85 ? 37 ILE A CA 1 ATOM 277 C C . ILE A 1 37 ? 43.761 34.167 9.200 1.00 13.20 ? 37 ILE A C 1 ATOM 278 O O . ILE A 1 37 ? 43.937 34.548 10.360 1.00 13.51 ? 37 ILE A O 1 ATOM 279 C CB . ILE A 1 37 ? 45.773 34.960 7.901 1.00 13.59 ? 37 ILE A CB 1 ATOM 280 C CG1 . ILE A 1 37 ? 46.251 35.987 6.880 1.00 12.94 ? 37 ILE A CG1 1 ATOM 281 C CG2 . ILE A 1 37 ? 46.208 33.553 7.520 1.00 14.51 ? 37 ILE A CG2 1 ATOM 282 C CD1 . ILE A 1 37 ? 47.749 36.022 6.691 1.00 13.28 ? 37 ILE A CD1 1 ATOM 283 N N . ILE A 1 38 ? 43.106 33.054 8.887 1.00 13.62 ? 38 ILE A N 1 ATOM 284 C CA . ILE A 1 38 ? 42.895 32.018 9.864 1.00 13.68 ? 38 ILE A CA 1 ATOM 285 C C . ILE A 1 38 ? 43.777 30.849 9.489 1.00 13.95 ? 38 ILE A C 1 ATOM 286 O O . ILE A 1 38 ? 43.685 30.342 8.370 1.00 13.81 ? 38 ILE A O 1 ATOM 287 C CB . ILE A 1 38 ? 41.418 31.584 9.988 1.00 13.57 ? 38 ILE A CB 1 ATOM 288 C CG1 . ILE A 1 38 ? 41.306 30.453 11.016 1.00 14.96 ? 38 ILE A CG1 1 ATOM 289 C CG2 . ILE A 1 38 ? 40.815 31.143 8.624 1.00 14.06 ? 38 ILE A CG2 1 ATOM 290 C CD1 . ILE A 1 38 ? 39.921 30.202 11.476 1.00 18.42 ? 38 ILE A CD1 1 ATOM 291 N N . PHE A 1 39 ? 44.648 30.459 10.422 1.00 13.48 ? 39 PHE A N 1 ATOM 292 C CA . PHE A 1 39 ? 45.395 29.213 10.334 1.00 13.27 ? 39 PHE A CA 1 ATOM 293 C C . PHE A 1 39 ? 44.674 28.192 11.200 1.00 13.22 ? 39 PHE A C 1 ATOM 294 O O . PHE A 1 39 ? 44.530 28.403 12.396 1.00 13.55 ? 39 PHE A O 1 ATOM 295 C CB . PHE A 1 39 ? 46.832 29.377 10.843 1.00 13.50 ? 39 PHE A CB 1 ATOM 296 C CG . PHE A 1 39 ? 47.599 30.476 10.173 1.00 14.28 ? 39 PHE A CG 1 ATOM 297 C CD1 . PHE A 1 39 ? 47.613 31.749 10.713 1.00 12.90 ? 39 PHE A CD1 1 ATOM 298 C CD2 . PHE A 1 39 ? 48.339 30.226 9.027 1.00 15.12 ? 39 PHE A CD2 1 ATOM 299 C CE1 . PHE A 1 39 ? 48.338 32.758 10.120 1.00 14.29 ? 39 PHE A CE1 1 ATOM 300 C CE2 . PHE A 1 39 ? 49.071 31.243 8.428 1.00 15.17 ? 39 PHE A CE2 1 ATOM 301 C CZ . PHE A 1 39 ? 49.062 32.513 8.980 1.00 13.91 ? 39 PHE A CZ 1 ATOM 302 N N . LEU A 1 40 ? 44.242 27.098 10.580 1.00 13.24 ? 40 LEU A N 1 ATOM 303 C CA . LEU A 1 40 ? 43.478 26.054 11.232 1.00 12.64 ? 40 LEU A CA 1 ATOM 304 C C . LEU A 1 40 ? 44.301 24.781 11.242 1.00 12.55 ? 40 LEU A C 1 ATOM 305 O O . LEU A 1 40 ? 44.584 24.166 10.187 1.00 12.05 ? 40 LEU A O 1 ATOM 306 C CB . LEU A 1 40 ? 42.143 25.850 10.497 1.00 12.59 ? 40 LEU A CB 1 ATOM 307 C CG . LEU A 1 40 ? 40.990 25.122 11.169 1.00 12.03 ? 40 LEU A CG 1 ATOM 308 C CD1 . LEU A 1 40 ? 41.253 23.627 11.319 1.00 10.91 ? 40 LEU A CD1 1 ATOM 309 C CD2 . LEU A 1 40 ? 40.658 25.751 12.536 1.00 12.59 ? 40 LEU A CD2 1 ATOM 310 N N . GLY A 1 41 ? 44.720 24.422 12.441 1.00 12.03 ? 41 GLY A N 1 ATOM 311 C CA . GLY A 1 41 ? 45.374 23.160 12.695 1.00 12.30 ? 41 GLY A CA 1 ATOM 312 C C . GLY A 1 41 ? 44.276 22.169 12.966 1.00 11.88 ? 41 GLY A C 1 ATOM 313 O O . GLY A 1 41 ? 43.674 22.197 14.023 1.00 12.10 ? 41 GLY A O 1 ATOM 314 N N . ASP A 1 42 ? 43.993 21.300 12.009 1.00 12.39 ? 42 ASP A N 1 ATOM 315 C CA . ASP A 1 42 ? 42.895 20.388 12.183 1.00 12.64 ? 42 ASP A CA 1 ATOM 316 C C . ASP A 1 42 ? 43.300 19.321 13.193 1.00 12.56 ? 42 ASP A C 1 ATOM 317 O O . ASP A 1 42 ? 44.225 18.568 12.961 1.00 13.46 ? 42 ASP A O 1 ATOM 318 C CB . ASP A 1 42 ? 42.463 19.765 10.867 1.00 12.71 ? 42 ASP A CB 1 ATOM 319 C CG . ASP A 1 42 ? 41.102 19.158 10.966 1.00 12.01 ? 42 ASP A CG 1 ATOM 320 O OD1 . ASP A 1 42 ? 40.834 18.454 11.948 1.00 14.15 ? 42 ASP A OD1 1 ATOM 321 O OD2 . ASP A 1 42 ? 40.215 19.364 10.144 1.00 10.92 ? 42 ASP A OD2 1 ATOM 322 N N . GLY A 1 43 ? 42.622 19.297 14.337 1.00 12.92 ? 43 GLY A N 1 ATOM 323 C CA . GLY A 1 43 ? 42.911 18.317 15.371 1.00 12.61 ? 43 GLY A CA 1 ATOM 324 C C . GLY A 1 43 ? 43.984 18.766 16.353 1.00 12.60 ? 43 GLY A C 1 ATOM 325 O O . GLY A 1 43 ? 44.366 18.012 17.261 1.00 13.12 ? 43 GLY A O 1 ATOM 326 N N . MET A 1 44 ? 44.454 19.994 16.193 1.00 12.26 ? 44 MET A N 1 ATOM 327 C CA . MET A 1 44 ? 45.614 20.491 16.921 1.00 12.45 ? 44 MET A CA 1 ATOM 328 C C . MET A 1 44 ? 45.245 21.061 18.295 1.00 12.58 ? 44 MET A C 1 ATOM 329 O O . MET A 1 44 ? 45.246 22.283 18.517 1.00 12.78 ? 44 MET A O 1 ATOM 330 C CB . MET A 1 44 ? 46.351 21.546 16.070 1.00 12.21 ? 44 MET A CB 1 ATOM 331 C CG . MET A 1 44 ? 47.740 21.898 16.576 1.00 12.12 ? 44 MET A CG 1 ATOM 332 S SD . MET A 1 44 ? 48.370 23.447 15.918 1.00 13.33 ? 44 MET A SD 1 ATOM 333 C CE . MET A 1 44 ? 47.354 24.686 16.747 1.00 13.58 ? 44 MET A CE 1 ATOM 334 N N . GLY A 1 45 ? 44.936 20.159 19.217 1.00 12.74 ? 45 GLY A N 1 ATOM 335 C CA . GLY A 1 45 ? 44.627 20.534 20.575 1.00 12.78 ? 45 GLY A CA 1 ATOM 336 C C . GLY A 1 45 ? 45.862 20.907 21.373 1.00 12.77 ? 45 GLY A C 1 ATOM 337 O O . GLY A 1 45 ? 46.986 20.862 20.880 1.00 12.40 ? 45 GLY A O 1 ATOM 338 N N . VAL A 1 46 ? 45.639 21.237 22.636 1.00 13.18 ? 46 VAL A N 1 ATOM 339 C CA . VAL A 1 46 ? 46.697 21.737 23.512 1.00 13.26 ? 46 VAL A CA 1 ATOM 340 C C . VAL A 1 46 ? 47.827 20.713 23.660 1.00 13.66 ? 46 VAL A C 1 ATOM 341 O O . VAL A 1 46 ? 49.006 21.091 23.619 1.00 12.90 ? 46 VAL A O 1 ATOM 342 C CB . VAL A 1 46 ? 46.100 22.188 24.879 1.00 13.68 ? 46 VAL A CB 1 ATOM 343 C CG1 . VAL A 1 46 ? 47.180 22.541 25.886 1.00 14.17 ? 46 VAL A CG1 1 ATOM 344 C CG2 . VAL A 1 46 ? 45.174 23.394 24.656 1.00 13.33 ? 46 VAL A CG2 1 ATOM 345 N N . SER A 1 47 ? 47.483 19.424 23.760 1.00 13.30 ? 47 SER A N 1 ATOM 346 C CA . SER A 1 47 ? 48.514 18.400 23.903 1.00 13.88 ? 47 SER A CA 1 ATOM 347 C C . SER A 1 47 ? 49.318 18.258 22.621 1.00 13.43 ? 47 SER A C 1 ATOM 348 O O . SER A 1 47 ? 50.505 17.982 22.679 1.00 14.26 ? 47 SER A O 1 ATOM 349 C CB . SER A 1 47 ? 47.925 17.057 24.355 1.00 14.06 ? 47 SER A CB 1 ATOM 350 O OG . SER A 1 47 ? 46.962 16.594 23.429 1.00 17.01 ? 47 SER A OG 1 ATOM 351 N N . THR A 1 48 ? 48.676 18.478 21.471 1.00 12.95 ? 48 THR A N 1 ATOM 352 C CA . THR A 1 48 ? 49.360 18.424 20.184 1.00 12.65 ? 48 THR A CA 1 ATOM 353 C C . THR A 1 48 ? 50.345 19.593 20.105 1.00 12.77 ? 48 THR A C 1 ATOM 354 O O . THR A 1 48 ? 51.490 19.396 19.750 1.00 12.65 ? 48 THR A O 1 ATOM 355 C CB . THR A 1 48 ? 48.353 18.449 19.028 1.00 12.51 ? 48 THR A CB 1 ATOM 356 O OG1 . THR A 1 48 ? 47.490 17.303 19.115 1.00 10.46 ? 48 THR A OG1 1 ATOM 357 C CG2 . THR A 1 48 ? 49.049 18.335 17.667 1.00 13.24 ? 48 THR A CG2 1 ATOM 358 N N . VAL A 1 49 ? 49.905 20.789 20.503 1.00 13.68 ? 49 VAL A N 1 ATOM 359 C CA . VAL A 1 49 ? 50.763 21.975 20.464 1.00 13.65 ? 49 VAL A CA 1 ATOM 360 C C . VAL A 1 49 ? 52.017 21.801 21.317 1.00 14.19 ? 49 VAL A C 1 ATOM 361 O O . VAL A 1 49 ? 53.140 21.996 20.816 1.00 14.12 ? 49 VAL A O 1 ATOM 362 C CB . VAL A 1 49 ? 49.994 23.248 20.844 1.00 14.03 ? 49 VAL A CB 1 ATOM 363 C CG1 . VAL A 1 49 ? 50.935 24.438 20.964 1.00 14.96 ? 49 VAL A CG1 1 ATOM 364 C CG2 . VAL A 1 49 ? 48.919 23.521 19.797 1.00 13.08 ? 49 VAL A CG2 1 ATOM 365 N N . THR A 1 50 ? 51.855 21.396 22.575 1.00 14.09 ? 50 THR A N 1 ATOM 366 C CA . THR A 1 50 ? 53.018 21.203 23.438 1.00 14.54 ? 50 THR A CA 1 ATOM 367 C C . THR A 1 50 ? 53.957 20.132 22.878 1.00 14.21 ? 50 THR A C 1 ATOM 368 O O . THR A 1 50 ? 55.175 20.327 22.821 1.00 14.48 ? 50 THR A O 1 ATOM 369 C CB . THR A 1 50 ? 52.583 20.802 24.850 1.00 14.51 ? 50 THR A CB 1 ATOM 370 O OG1 . THR A 1 50 ? 51.728 21.808 25.407 1.00 14.77 ? 50 THR A OG1 1 ATOM 371 C CG2 . THR A 1 50 ? 53.795 20.707 25.788 1.00 15.49 ? 50 THR A CG2 1 ATOM 372 N N . ALA A 1 51 ? 53.402 18.991 22.480 1.00 14.12 ? 51 ALA A N 1 ATOM 373 C CA . ALA A 1 51 ? 54.235 17.902 21.918 1.00 14.48 ? 51 ALA A CA 1 ATOM 374 C C . ALA A 1 51 ? 55.018 18.354 20.676 1.00 14.61 ? 51 ALA A C 1 ATOM 375 O O . ALA A 1 51 ? 56.221 18.061 20.533 1.00 14.30 ? 51 ALA A O 1 ATOM 376 C CB . ALA A 1 51 ? 53.376 16.680 21.600 1.00 14.71 ? 51 ALA A CB 1 ATOM 377 N N . ALA A 1 52 ? 54.325 19.066 19.796 1.00 14.49 ? 52 ALA A N 1 ATOM 378 C CA . ALA A 1 52 ? 54.918 19.656 18.607 1.00 14.67 ? 52 ALA A CA 1 ATOM 379 C C . ALA A 1 52 ? 56.049 20.610 18.938 1.00 14.97 ? 52 ALA A C 1 ATOM 380 O O . ALA A 1 52 ? 57.074 20.603 18.261 1.00 15.13 ? 52 ALA A O 1 ATOM 381 C CB . ALA A 1 52 ? 53.864 20.384 17.790 1.00 14.87 ? 52 ALA A CB 1 ATOM 382 N N . ARG A 1 53 ? 55.847 21.442 19.958 1.00 14.70 ? 53 ARG A N 1 ATOM 383 C CA . ARG A 1 53 ? 56.862 22.402 20.379 1.00 15.12 ? 53 ARG A CA 1 ATOM 384 C C . ARG A 1 53 ? 58.155 21.676 20.781 1.00 15.96 ? 53 ARG A C 1 ATOM 385 O O . ARG A 1 53 ? 59.278 22.087 20.386 1.00 15.29 ? 53 ARG A O 1 ATOM 386 C CB . ARG A 1 53 ? 56.326 23.220 21.558 1.00 15.37 ? 53 ARG A CB 1 ATOM 387 C CG . ARG A 1 53 ? 57.246 24.299 22.074 1.00 14.66 ? 53 ARG A CG 1 ATOM 388 C CD . ARG A 1 53 ? 56.769 24.892 23.386 1.00 14.17 ? 53 ARG A CD 1 ATOM 389 N NE . ARG A 1 53 ? 55.429 25.486 23.226 1.00 13.17 ? 53 ARG A NE 1 ATOM 390 C CZ . ARG A 1 53 ? 54.382 25.263 24.005 1.00 13.23 ? 53 ARG A CZ 1 ATOM 391 N NH1 . ARG A 1 53 ? 53.250 25.900 23.754 1.00 10.92 ? 53 ARG A NH1 1 ATOM 392 N NH2 . ARG A 1 53 ? 54.442 24.427 25.034 1.00 14.27 ? 53 ARG A NH2 1 ATOM 393 N N . ILE A 1 54 ? 57.994 20.606 21.559 1.00 16.04 ? 54 ILE A N 1 ATOM 394 C CA . ILE A 1 54 ? 59.131 19.849 22.056 1.00 16.36 ? 54 ILE A CA 1 ATOM 395 C C . ILE A 1 54 ? 59.874 19.255 20.871 1.00 16.85 ? 54 ILE A C 1 ATOM 396 O O . ILE A 1 54 ? 61.092 19.411 20.777 1.00 16.23 ? 54 ILE A O 1 ATOM 397 C CB . ILE A 1 54 ? 58.699 18.763 23.089 1.00 16.44 ? 54 ILE A CB 1 ATOM 398 C CG1 . ILE A 1 54 ? 58.276 19.439 24.404 1.00 15.57 ? 54 ILE A CG1 1 ATOM 399 C CG2 . ILE A 1 54 ? 59.853 17.774 23.345 1.00 16.65 ? 54 ILE A CG2 1 ATOM 400 C CD1 . ILE A 1 54 ? 57.611 18.520 25.407 1.00 15.96 ? 54 ILE A CD1 1 ATOM 401 N N . LEU A 1 55 ? 59.141 18.611 19.957 1.00 16.85 ? 55 LEU A N 1 ATOM 402 C CA . LEU A 1 55 ? 59.747 18.006 18.761 1.00 17.65 ? 55 LEU A CA 1 ATOM 403 C C . LEU A 1 55 ? 60.501 19.034 17.931 1.00 17.83 ? 55 LEU A C 1 ATOM 404 O O . LEU A 1 55 ? 61.649 18.799 17.541 1.00 17.46 ? 55 LEU A O 1 ATOM 405 C CB . LEU A 1 55 ? 58.676 17.326 17.890 1.00 17.75 ? 55 LEU A CB 1 ATOM 406 C CG . LEU A 1 55 ? 59.159 16.634 16.607 1.00 17.62 ? 55 LEU A CG 1 ATOM 407 C CD1 . LEU A 1 55 ? 60.227 15.576 16.915 1.00 17.09 ? 55 LEU A CD1 1 ATOM 408 C CD2 . LEU A 1 55 ? 57.977 16.023 15.858 1.00 18.06 ? 55 LEU A CD2 1 ATOM 409 N N . LYS A 1 56 ? 59.853 20.168 17.654 1.00 17.96 ? 56 LYS A N 1 ATOM 410 C CA . LYS A 1 56 ? 60.465 21.226 16.863 1.00 18.38 ? 56 LYS A CA 1 ATOM 411 C C . LYS A 1 56 ? 61.700 21.787 17.564 1.00 18.90 ? 56 LYS A C 1 ATOM 412 O O . LYS A 1 56 ? 62.710 22.065 16.917 1.00 18.14 ? 56 LYS A O 1 ATOM 413 C CB . LYS A 1 56 ? 59.474 22.356 16.568 1.00 18.01 ? 56 LYS A CB 1 ATOM 414 C CG . LYS A 1 56 ? 60.021 23.451 15.602 1.00 18.90 ? 56 LYS A CG 1 ATOM 415 C CD . LYS A 1 56 ? 58.919 24.365 15.116 1.00 18.48 ? 56 LYS A CD 1 ATOM 416 C CE . LYS A 1 56 ? 59.390 25.372 14.044 1.00 18.79 ? 56 LYS A CE 1 ATOM 417 N NZ . LYS A 1 56 ? 58.213 26.105 13.488 1.00 16.69 ? 56 LYS A NZ 1 ATOM 418 N N . GLY A 1 57 ? 61.618 21.948 18.883 1.00 19.87 ? 57 GLY A N 1 ATOM 419 C CA . GLY A 1 57 ? 62.745 22.468 19.651 1.00 21.29 ? 57 GLY A CA 1 ATOM 420 C C . GLY A 1 57 ? 63.950 21.566 19.487 1.00 22.19 ? 57 GLY A C 1 ATOM 421 O O . GLY A 1 57 ? 65.065 22.038 19.329 1.00 23.39 ? 57 GLY A O 1 ATOM 422 N N . GLN A 1 58 ? 63.718 20.259 19.485 1.00 23.09 ? 58 GLN A N 1 ATOM 423 C CA . GLN A 1 58 ? 64.797 19.290 19.335 1.00 24.16 ? 58 GLN A CA 1 ATOM 424 C C . GLN A 1 58 ? 65.271 19.175 17.892 1.00 25.29 ? 58 GLN A C 1 ATOM 425 O O . GLN A 1 58 ? 66.454 18.925 17.658 1.00 25.21 ? 58 GLN A O 1 ATOM 426 C CB . GLN A 1 58 ? 64.368 17.935 19.878 1.00 23.84 ? 58 GLN A CB 1 ATOM 427 C CG . GLN A 1 58 ? 64.073 18.010 21.364 1.00 23.76 ? 58 GLN A CG 1 ATOM 428 C CD . GLN A 1 58 ? 63.577 16.728 21.933 1.00 22.99 ? 58 GLN A CD 1 ATOM 429 O OE1 . GLN A 1 58 ? 63.459 15.735 21.220 1.00 24.92 ? 58 GLN A OE1 1 ATOM 430 N NE2 . GLN A 1 58 ? 63.290 16.729 23.231 1.00 19.74 ? 58 GLN A NE2 1 ATOM 431 N N . LYS A 1 59 ? 64.355 19.365 16.942 1.00 26.95 ? 59 LYS A N 1 ATOM 432 C CA . LYS A 1 59 ? 64.685 19.430 15.505 1.00 28.48 ? 59 LYS A CA 1 ATOM 433 C C . LYS A 1 59 ? 65.748 20.496 15.285 1.00 29.38 ? 59 LYS A C 1 ATOM 434 O O . LYS A 1 59 ? 66.706 20.305 14.525 1.00 29.81 ? 59 LYS A O 1 ATOM 435 C CB . LYS A 1 59 ? 63.418 19.752 14.693 1.00 28.42 ? 59 LYS A CB 1 ATOM 436 C CG . LYS A 1 59 ? 63.613 19.930 13.202 1.00 29.53 ? 59 LYS A CG 1 ATOM 437 C CD . LYS A 1 59 ? 62.273 20.206 12.515 1.00 29.58 ? 59 LYS A CD 1 ATOM 438 C CE . LYS A 1 59 ? 62.389 20.100 11.003 1.00 31.00 ? 59 LYS A CE 1 ATOM 439 N NZ . LYS A 1 59 ? 61.143 20.559 10.330 1.00 31.14 ? 59 LYS A NZ 1 ATOM 440 N N . LYS A 1 60 ? 65.576 21.620 15.970 1.00 30.55 ? 60 LYS A N 1 ATOM 441 C CA . LYS A 1 60 ? 66.624 22.626 16.081 1.00 31.53 ? 60 LYS A CA 1 ATOM 442 C C . LYS A 1 60 ? 67.704 22.038 16.989 1.00 31.36 ? 60 LYS A C 1 ATOM 443 O O . LYS A 1 60 ? 67.807 20.825 17.089 1.00 32.43 ? 60 LYS A O 1 ATOM 444 C CB . LYS A 1 60 ? 66.029 23.940 16.584 1.00 31.83 ? 60 LYS A CB 1 ATOM 445 C CG . LYS A 1 60 ? 65.220 24.628 15.487 1.00 34.15 ? 60 LYS A CG 1 ATOM 446 C CD . LYS A 1 60 ? 64.427 25.821 15.996 1.00 35.75 ? 60 LYS A CD 1 ATOM 447 C CE . LYS A 1 60 ? 62.947 25.539 16.078 1.00 36.44 ? 60 LYS A CE 1 ATOM 448 N NZ . LYS A 1 60 ? 62.161 26.814 16.059 1.00 36.79 ? 60 LYS A NZ 1 ATOM 449 N N . ASP A 1 61 ? 68.538 22.830 17.632 1.00 31.12 ? 61 ASP A N 1 ATOM 450 C CA . ASP A 1 61 ? 69.603 22.208 18.421 1.00 30.87 ? 61 ASP A CA 1 ATOM 451 C C . ASP A 1 61 ? 69.308 22.189 19.924 1.00 29.90 ? 61 ASP A C 1 ATOM 452 O O . ASP A 1 61 ? 70.224 22.237 20.726 1.00 29.98 ? 61 ASP A O 1 ATOM 453 C CB . ASP A 1 61 ? 70.922 22.893 18.138 1.00 31.36 ? 61 ASP A CB 1 ATOM 454 N N . LYS A 1 62 ? 68.032 22.066 20.301 1.00 28.49 ? 62 LYS A N 1 ATOM 455 C CA . LYS A 1 62 ? 67.613 22.409 21.655 1.00 27.07 ? 62 LYS A CA 1 ATOM 456 C C . LYS A 1 62 ? 66.997 21.241 22.423 1.00 25.71 ? 62 LYS A C 1 ATOM 457 O O . LYS A 1 62 ? 66.784 20.171 21.882 1.00 25.49 ? 62 LYS A O 1 ATOM 458 C CB . LYS A 1 62 ? 66.632 23.579 21.586 1.00 27.44 ? 62 LYS A CB 1 ATOM 459 C CG . LYS A 1 62 ? 67.040 24.681 20.595 1.00 29.04 ? 62 LYS A CG 1 ATOM 460 C CD . LYS A 1 62 ? 68.266 25.429 21.071 1.00 31.02 ? 62 LYS A CD 1 ATOM 461 C CE . LYS A 1 62 ? 68.629 26.563 20.125 1.00 32.30 ? 62 LYS A CE 1 ATOM 462 N NZ . LYS A 1 62 ? 70.065 26.932 20.228 1.00 33.01 ? 62 LYS A NZ 1 ATOM 463 N N . LEU A 1 63 ? 66.718 21.458 23.701 1.00 24.26 ? 63 LEU A N 1 ATOM 464 C CA . LEU A 1 63 ? 66.162 20.409 24.551 1.00 23.39 ? 63 LEU A CA 1 ATOM 465 C C . LEU A 1 63 ? 64.674 20.171 24.278 1.00 22.01 ? 63 LEU A C 1 ATOM 466 O O . LEU A 1 63 ? 64.187 19.059 24.470 1.00 21.23 ? 63 LEU A O 1 ATOM 467 C CB . LEU A 1 63 ? 66.397 20.750 26.026 1.00 23.35 ? 63 LEU A CB 1 ATOM 468 C CG . LEU A 1 63 ? 67.871 20.795 26.414 1.00 24.21 ? 63 LEU A CG 1 ATOM 469 C CD1 . LEU A 1 63 ? 68.037 21.343 27.816 1.00 25.23 ? 63 LEU A CD1 1 ATOM 470 C CD2 . LEU A 1 63 ? 68.502 19.401 26.306 1.00 25.83 ? 63 LEU A CD2 1 ATOM 471 N N . GLY A 1 64 ? 63.956 21.209 23.838 1.00 21.48 ? 64 GLY A N 1 ATOM 472 C CA . GLY A 1 64 ? 62.558 21.053 23.396 1.00 21.17 ? 64 GLY A CA 1 ATOM 473 C C . GLY A 1 64 ? 61.577 22.107 23.902 1.00 20.92 ? 64 GLY A C 1 ATOM 474 O O . GLY A 1 64 ? 61.297 23.090 23.200 1.00 20.95 ? 64 GLY A O 1 ATOM 475 N N . PRO A 1 65 ? 61.077 21.915 25.124 1.00 20.74 ? 65 PRO A N 1 ATOM 476 C CA . PRO A 1 65 ? 59.907 22.654 25.643 1.00 20.56 ? 65 PRO A CA 1 ATOM 477 C C . PRO A 1 65 ? 60.116 24.162 25.873 1.00 20.36 ? 65 PRO A C 1 ATOM 478 O O . PRO A 1 65 ? 59.150 24.932 25.949 1.00 19.56 ? 65 PRO A O 1 ATOM 479 C CB . PRO A 1 65 ? 59.616 21.937 26.966 1.00 20.64 ? 65 PRO A CB 1 ATOM 480 C CG . PRO A 1 65 ? 60.958 21.427 27.412 1.00 20.87 ? 65 PRO A CG 1 ATOM 481 C CD . PRO A 1 65 ? 61.619 20.974 26.127 1.00 21.06 ? 65 PRO A CD 1 ATOM 482 N N . GLU A 1 66 ? 61.368 24.572 25.986 1.00 20.61 ? 66 GLU A N 1 ATOM 483 C CA . GLU A 1 66 ? 61.710 25.973 26.206 1.00 20.78 ? 66 GLU A CA 1 ATOM 484 C C . GLU A 1 66 ? 61.721 26.818 24.925 1.00 20.74 ? 66 GLU A C 1 ATOM 485 O O . GLU A 1 66 ? 61.807 28.053 24.997 1.00 20.92 ? 66 GLU A O 1 ATOM 486 C CB . GLU A 1 66 ? 63.074 26.068 26.903 1.00 21.10 ? 66 GLU A CB 1 ATOM 487 C CG . GLU A 1 66 ? 64.297 25.781 26.034 1.00 20.44 ? 66 GLU A CG 1 ATOM 488 C CD . GLU A 1 66 ? 64.435 24.318 25.622 1.00 22.54 ? 66 GLU A CD 1 ATOM 489 O OE1 . GLU A 1 66 ? 63.862 23.408 26.287 1.00 18.93 ? 66 GLU A OE1 1 ATOM 490 O OE2 . GLU A 1 66 ? 65.133 24.075 24.624 1.00 23.96 ? 66 GLU A OE2 1 ATOM 491 N N . ILE A 1 67 ? 61.672 26.164 23.763 1.00 20.89 ? 67 ILE A N 1 ATOM 492 C CA . ILE A 1 67 ? 61.741 26.860 22.459 1.00 20.72 ? 67 ILE A CA 1 ATOM 493 C C . ILE A 1 67 ? 60.314 27.163 21.987 1.00 20.44 ? 67 ILE A C 1 ATOM 494 O O . ILE A 1 67 ? 59.539 26.221 21.785 1.00 19.47 ? 67 ILE A O 1 ATOM 495 C CB . ILE A 1 67 ? 62.448 25.962 21.394 1.00 20.86 ? 67 ILE A CB 1 ATOM 496 C CG1 . ILE A 1 67 ? 63.810 25.451 21.899 1.00 23.06 ? 67 ILE A CG1 1 ATOM 497 C CG2 . ILE A 1 67 ? 62.594 26.696 20.046 1.00 21.19 ? 67 ILE A CG2 1 ATOM 498 C CD1 . ILE A 1 67 ? 64.822 26.552 22.250 1.00 24.10 ? 67 ILE A CD1 1 ATOM 499 N N . PRO A 1 68 ? 59.946 28.447 21.818 1.00 19.29 ? 68 PRO A N 1 ATOM 500 C CA . PRO A 1 68 ? 58.630 28.776 21.273 1.00 18.86 ? 68 PRO A CA 1 ATOM 501 C C . PRO A 1 68 ? 58.415 28.341 19.833 1.00 18.21 ? 68 PRO A C 1 ATOM 502 O O . PRO A 1 68 ? 59.296 28.518 18.973 1.00 17.79 ? 68 PRO A O 1 ATOM 503 C CB . PRO A 1 68 ? 58.570 30.316 21.351 1.00 18.63 ? 68 PRO A CB 1 ATOM 504 C CG . PRO A 1 68 ? 59.599 30.677 22.373 1.00 19.70 ? 68 PRO A CG 1 ATOM 505 C CD . PRO A 1 68 ? 60.695 29.667 22.176 1.00 19.58 ? 68 PRO A CD 1 ATOM 506 N N . LEU A 1 69 ? 57.220 27.812 19.585 1.00 16.64 ? 69 LEU A N 1 ATOM 507 C CA . LEU A 1 69 ? 56.661 27.714 18.235 1.00 15.80 ? 69 LEU A CA 1 ATOM 508 C C . LEU A 1 69 ? 56.388 29.122 17.722 1.00 15.21 ? 69 LEU A C 1 ATOM 509 O O . LEU A 1 69 ? 56.251 30.054 18.506 1.00 14.71 ? 69 LEU A O 1 ATOM 510 C CB . LEU A 1 69 ? 55.346 26.934 18.273 1.00 15.11 ? 69 LEU A CB 1 ATOM 511 C CG . LEU A 1 69 ? 55.451 25.475 18.694 1.00 15.47 ? 69 LEU A CG 1 ATOM 512 C CD1 . LEU A 1 69 ? 54.073 24.900 19.044 1.00 14.70 ? 69 LEU A CD1 1 ATOM 513 C CD2 . LEU A 1 69 ? 56.148 24.669 17.623 1.00 16.43 ? 69 LEU A CD2 1 ATOM 514 N N . ALA A 1 70 ? 56.303 29.285 16.408 1.00 14.81 ? 70 ALA A N 1 ATOM 515 C CA . ALA A 1 70 ? 55.830 30.558 15.855 1.00 14.72 ? 70 ALA A CA 1 ATOM 516 C C . ALA A 1 70 ? 54.472 30.958 16.456 1.00 14.33 ? 70 ALA A C 1 ATOM 517 O O . ALA A 1 70 ? 54.283 32.109 16.870 1.00 13.58 ? 70 ALA A O 1 ATOM 518 C CB . ALA A 1 70 ? 55.759 30.495 14.356 1.00 14.85 ? 70 ALA A CB 1 ATOM 519 N N . MET A 1 71 ? 53.541 30.009 16.562 1.00 14.17 ? 71 MET A N 1 ATOM 520 C CA . MET A 1 71 ? 52.243 30.314 17.159 1.00 14.34 ? 71 MET A CA 1 ATOM 521 C C . MET A 1 71 ? 52.361 30.749 18.614 1.00 14.29 ? 71 MET A C 1 ATOM 522 O O . MET A 1 71 ? 51.567 31.564 19.055 1.00 15.07 ? 71 MET A O 1 ATOM 523 C CB . MET A 1 71 ? 51.257 29.140 17.038 1.00 14.53 ? 71 MET A CB 1 ATOM 524 C CG . MET A 1 71 ? 51.617 27.919 17.846 1.00 15.13 ? 71 MET A CG 1 ATOM 525 S SD . MET A 1 71 ? 50.479 26.574 17.511 1.00 16.17 ? 71 MET A SD 1 ATOM 526 C CE . MET A 1 71 ? 50.960 26.124 15.842 1.00 16.47 ? 71 MET A CE 1 ATOM 527 N N . ASP A 1 72 ? 53.353 30.230 19.349 1.00 14.58 ? 72 ASP A N 1 ATOM 528 C CA . ASP A 1 72 ? 53.577 30.618 20.755 1.00 14.53 ? 72 ASP A CA 1 ATOM 529 C C . ASP A 1 72 ? 53.910 32.100 20.917 1.00 15.08 ? 72 ASP A C 1 ATOM 530 O O . ASP A 1 72 ? 53.749 32.654 21.987 1.00 14.82 ? 72 ASP A O 1 ATOM 531 C CB . ASP A 1 72 ? 54.748 29.875 21.376 1.00 14.21 ? 72 ASP A CB 1 ATOM 532 C CG . ASP A 1 72 ? 54.491 28.421 21.607 1.00 15.36 ? 72 ASP A CG 1 ATOM 533 O OD1 . ASP A 1 72 ? 53.328 27.975 21.609 1.00 13.93 ? 72 ASP A OD1 1 ATOM 534 O OD2 . ASP A 1 72 ? 55.447 27.644 21.833 1.00 13.42 ? 72 ASP A OD2 1 ATOM 535 N N . ARG A 1 73 ? 54.417 32.718 19.861 1.00 15.71 ? 73 ARG A N 1 ATOM 536 C CA . ARG A 1 73 ? 54.804 34.110 19.900 1.00 16.11 ? 73 ARG A CA 1 ATOM 537 C C . ARG A 1 73 ? 53.619 35.052 19.748 1.00 15.85 ? 73 ARG A C 1 ATOM 538 O O . ARG A 1 73 ? 53.770 36.242 19.992 1.00 16.05 ? 73 ARG A O 1 ATOM 539 C CB . ARG A 1 73 ? 55.816 34.399 18.792 1.00 16.80 ? 73 ARG A CB 1 ATOM 540 C CG . ARG A 1 73 ? 57.050 33.568 18.896 1.00 19.91 ? 73 ARG A CG 1 ATOM 541 C CD . ARG A 1 73 ? 58.181 34.060 18.033 1.00 24.51 ? 73 ARG A CD 1 ATOM 542 N NE . ARG A 1 73 ? 59.372 33.233 18.186 1.00 26.81 ? 73 ARG A NE 1 ATOM 543 C CZ . ARG A 1 73 ? 60.202 33.282 19.233 1.00 28.69 ? 73 ARG A CZ 1 ATOM 544 N NH1 . ARG A 1 73 ? 60.005 34.122 20.245 1.00 29.76 ? 73 ARG A NH1 1 ATOM 545 N NH2 . ARG A 1 73 ? 61.253 32.471 19.263 1.00 29.89 ? 73 ARG A NH2 1 ATOM 546 N N . PHE A 1 74 ? 52.444 34.533 19.366 1.00 15.32 ? 74 PHE A N 1 ATOM 547 C CA . PHE A 1 74 ? 51.248 35.365 19.213 1.00 14.42 ? 74 PHE A CA 1 ATOM 548 C C . PHE A 1 74 ? 50.878 35.887 20.611 1.00 14.78 ? 74 PHE A C 1 ATOM 549 O O . PHE A 1 74 ? 50.895 35.121 21.579 1.00 15.29 ? 74 PHE A O 1 ATOM 550 C CB . PHE A 1 74 ? 50.073 34.561 18.635 1.00 14.17 ? 74 PHE A CB 1 ATOM 551 C CG . PHE A 1 74 ? 50.131 34.324 17.145 1.00 12.61 ? 74 PHE A CG 1 ATOM 552 C CD1 . PHE A 1 74 ? 51.294 33.859 16.518 1.00 12.59 ? 74 PHE A CD1 1 ATOM 553 C CD2 . PHE A 1 74 ? 48.991 34.520 16.367 1.00 14.06 ? 74 PHE A CD2 1 ATOM 554 C CE1 . PHE A 1 74 ? 51.319 33.643 15.151 1.00 13.81 ? 74 PHE A CE1 1 ATOM 555 C CE2 . PHE A 1 74 ? 48.994 34.273 14.991 1.00 12.73 ? 74 PHE A CE2 1 ATOM 556 C CZ . PHE A 1 74 ? 50.159 33.842 14.383 1.00 14.37 ? 74 PHE A CZ 1 ATOM 557 N N . PRO A 1 75 ? 50.581 37.173 20.735 1.00 14.62 ? 75 PRO A N 1 ATOM 558 C CA . PRO A 1 75 ? 50.351 37.786 22.042 1.00 15.15 ? 75 PRO A CA 1 ATOM 559 C C . PRO A 1 75 ? 49.053 37.386 22.724 1.00 15.06 ? 75 PRO A C 1 ATOM 560 O O . PRO A 1 75 ? 49.022 37.273 23.943 1.00 15.00 ? 75 PRO A O 1 ATOM 561 C CB . PRO A 1 75 ? 50.336 39.286 21.733 1.00 15.20 ? 75 PRO A CB 1 ATOM 562 C CG . PRO A 1 75 ? 49.944 39.386 20.301 1.00 16.03 ? 75 PRO A CG 1 ATOM 563 C CD . PRO A 1 75 ? 50.450 38.142 19.641 1.00 15.40 ? 75 PRO A CD 1 ATOM 564 N N . TYR A 1 76 ? 47.991 37.156 21.960 1.00 15.45 ? 76 TYR A N 1 ATOM 565 C CA . TYR A 1 76 ? 46.688 36.946 22.571 1.00 15.91 ? 76 TYR A CA 1 ATOM 566 C C . TYR A 1 76 ? 46.208 35.537 22.406 1.00 15.92 ? 76 TYR A C 1 ATOM 567 O O . TYR A 1 76 ? 46.255 34.990 21.307 1.00 15.26 ? 76 TYR A O 1 ATOM 568 C CB . TYR A 1 76 ? 45.675 37.902 21.974 1.00 16.51 ? 76 TYR A CB 1 ATOM 569 C CG . TYR A 1 76 ? 46.101 39.307 22.193 1.00 17.49 ? 76 TYR A CG 1 ATOM 570 C CD1 . TYR A 1 76 ? 46.112 39.846 23.467 1.00 17.31 ? 76 TYR A CD1 1 ATOM 571 C CD2 . TYR A 1 76 ? 46.539 40.085 21.134 1.00 17.68 ? 76 TYR A CD2 1 ATOM 572 C CE1 . TYR A 1 76 ? 46.535 41.122 23.682 1.00 18.09 ? 76 TYR A CE1 1 ATOM 573 C CE2 . TYR A 1 76 ? 46.949 41.381 21.332 1.00 18.77 ? 76 TYR A CE2 1 ATOM 574 C CZ . TYR A 1 76 ? 46.939 41.900 22.608 1.00 18.28 ? 76 TYR A CZ 1 ATOM 575 O OH . TYR A 1 76 ? 47.345 43.192 22.823 1.00 18.92 ? 76 TYR A OH 1 ATOM 576 N N . VAL A 1 77 ? 45.737 34.975 23.520 1.00 15.83 ? 77 VAL A N 1 ATOM 577 C CA . VAL A 1 77 ? 45.282 33.604 23.598 1.00 15.32 ? 77 VAL A CA 1 ATOM 578 C C . VAL A 1 77 ? 43.891 33.535 24.261 1.00 15.54 ? 77 VAL A C 1 ATOM 579 O O . VAL A 1 77 ? 43.575 34.272 25.213 1.00 14.66 ? 77 VAL A O 1 ATOM 580 C CB . VAL A 1 77 ? 46.333 32.734 24.331 1.00 15.83 ? 77 VAL A CB 1 ATOM 581 C CG1 . VAL A 1 77 ? 45.775 31.378 24.732 1.00 16.38 ? 77 VAL A CG1 1 ATOM 582 C CG2 . VAL A 1 77 ? 47.573 32.549 23.455 1.00 16.18 ? 77 VAL A CG2 1 ATOM 583 N N . ALA A 1 78 ? 43.041 32.674 23.717 1.00 14.78 ? 78 ALA A N 1 ATOM 584 C CA . ALA A 1 78 ? 41.756 32.375 24.314 1.00 14.33 ? 78 ALA A CA 1 ATOM 585 C C . ALA A 1 78 ? 41.550 30.868 24.231 1.00 13.94 ? 78 ALA A C 1 ATOM 586 O O . ALA A 1 78 ? 42.223 30.184 23.466 1.00 13.47 ? 78 ALA A O 1 ATOM 587 C CB . ALA A 1 78 ? 40.629 33.095 23.567 1.00 14.48 ? 78 ALA A CB 1 ATOM 588 N N . LEU A 1 79 ? 40.627 30.367 25.030 1.00 12.98 ? 79 LEU A N 1 ATOM 589 C CA . LEU A 1 79 ? 40.204 28.980 24.928 1.00 12.95 ? 79 LEU A CA 1 ATOM 590 C C . LEU A 1 79 ? 38.909 28.996 24.155 1.00 12.82 ? 79 LEU A C 1 ATOM 591 O O . LEU A 1 79 ? 38.072 29.848 24.394 1.00 13.57 ? 79 LEU A O 1 ATOM 592 C CB . LEU A 1 79 ? 40.007 28.364 26.306 1.00 12.49 ? 79 LEU A CB 1 ATOM 593 C CG . LEU A 1 79 ? 41.305 28.082 27.065 1.00 13.47 ? 79 LEU A CG 1 ATOM 594 C CD1 . LEU A 1 79 ? 40.974 27.659 28.469 1.00 14.68 ? 79 LEU A CD1 1 ATOM 595 C CD2 . LEU A 1 79 ? 42.119 27.019 26.354 1.00 14.29 ? 79 LEU A CD2 1 ATOM 596 N N . SER A 1 80 ? 38.773 28.066 23.216 1.00 12.95 ? 80 SER A N 1 ATOM 597 C CA . SER A 1 80 ? 37.608 27.966 22.352 1.00 12.67 ? 80 SER A CA 1 ATOM 598 C C . SER A 1 80 ? 36.813 26.714 22.685 1.00 12.61 ? 80 SER A C 1 ATOM 599 O O . SER A 1 80 ? 37.368 25.625 22.693 1.00 12.14 ? 80 SER A O 1 ATOM 600 C CB . SER A 1 80 ? 38.069 27.898 20.900 1.00 12.60 ? 80 SER A CB 1 ATOM 601 O OG . SER A 1 80 ? 36.988 27.620 20.037 1.00 13.82 ? 80 SER A OG 1 ATOM 602 N N . LYS A 1 81 ? 35.517 26.879 22.940 1.00 12.63 ? 81 LYS A N 1 ATOM 603 C CA . LYS A 1 81 ? 34.618 25.761 23.232 1.00 13.03 ? 81 LYS A CA 1 ATOM 604 C C . LYS A 1 81 ? 34.040 25.194 21.932 1.00 12.94 ? 81 LYS A C 1 ATOM 605 O O . LYS A 1 81 ? 33.302 25.881 21.218 1.00 12.44 ? 81 LYS A O 1 ATOM 606 C CB . LYS A 1 81 ? 33.495 26.222 24.163 1.00 12.81 ? 81 LYS A CB 1 ATOM 607 C CG . LYS A 1 81 ? 33.990 26.790 25.494 1.00 13.42 ? 81 LYS A CG 1 ATOM 608 C CD . LYS A 1 81 ? 32.889 26.799 26.553 1.00 14.12 ? 81 LYS A CD 1 ATOM 609 C CE . LYS A 1 81 ? 31.758 27.737 26.182 1.00 14.11 ? 81 LYS A CE 1 ATOM 610 N NZ . LYS A 1 81 ? 30.707 27.765 27.236 1.00 15.77 ? 81 LYS A NZ 1 ATOM 611 N N . THR A 1 82 ? 34.347 23.930 21.643 1.00 12.62 ? 82 THR A N 1 ATOM 612 C CA . THR A 1 82 ? 34.175 23.378 20.300 1.00 12.76 ? 82 THR A CA 1 ATOM 613 C C . THR A 1 82 ? 32.922 22.537 20.070 1.00 13.04 ? 82 THR A C 1 ATOM 614 O O . THR A 1 82 ? 32.700 22.108 18.960 1.00 13.79 ? 82 THR A O 1 ATOM 615 C CB . THR A 1 82 ? 35.384 22.515 19.936 1.00 12.46 ? 82 THR A CB 1 ATOM 616 O OG1 . THR A 1 82 ? 35.471 21.435 20.872 1.00 12.27 ? 82 THR A OG1 1 ATOM 617 C CG2 . THR A 1 82 ? 36.699 23.306 20.083 1.00 11.76 ? 82 THR A CG2 1 ATOM 618 N N . TYR A 1 83 ? 32.125 22.275 21.099 1.00 13.71 ? 83 TYR A N 1 ATOM 619 C CA . TYR A 1 83 ? 30.949 21.423 20.932 1.00 14.19 ? 83 TYR A CA 1 ATOM 620 C C . TYR A 1 83 ? 30.108 21.844 19.745 1.00 14.51 ? 83 TYR A C 1 ATOM 621 O O . TYR A 1 83 ? 29.925 23.034 19.475 1.00 15.23 ? 83 TYR A O 1 ATOM 622 C CB . TYR A 1 83 ? 30.085 21.396 22.193 1.00 14.27 ? 83 TYR A CB 1 ATOM 623 C CG . TYR A 1 83 ? 29.400 22.695 22.543 1.00 13.52 ? 83 TYR A CG 1 ATOM 624 C CD1 . TYR A 1 83 ? 30.052 23.686 23.266 1.00 13.24 ? 83 TYR A CD1 1 ATOM 625 C CD2 . TYR A 1 83 ? 28.088 22.933 22.146 1.00 14.50 ? 83 TYR A CD2 1 ATOM 626 C CE1 . TYR A 1 83 ? 29.398 24.891 23.598 1.00 12.55 ? 83 TYR A CE1 1 ATOM 627 C CE2 . TYR A 1 83 ? 27.438 24.105 22.471 1.00 12.63 ? 83 TYR A CE2 1 ATOM 628 C CZ . TYR A 1 83 ? 28.082 25.075 23.195 1.00 13.08 ? 83 TYR A CZ 1 ATOM 629 O OH . TYR A 1 83 ? 27.404 26.239 23.504 1.00 12.66 ? 83 TYR A OH 1 ATOM 630 N N . ASN A 1 84 ? 29.592 20.861 19.023 1.00 15.20 ? 84 ASN A N 1 ATOM 631 C CA . ASN A 1 84 ? 28.563 21.134 18.035 1.00 14.80 ? 84 ASN A CA 1 ATOM 632 C C . ASN A 1 84 ? 27.224 21.211 18.757 1.00 14.84 ? 84 ASN A C 1 ATOM 633 O O . ASN A 1 84 ? 27.110 20.843 19.926 1.00 14.69 ? 84 ASN A O 1 ATOM 634 C CB . ASN A 1 84 ? 28.527 20.053 16.967 1.00 14.84 ? 84 ASN A CB 1 ATOM 635 C CG . ASN A 1 84 ? 29.780 20.022 16.111 1.00 14.91 ? 84 ASN A CG 1 ATOM 636 O OD1 . ASN A 1 84 ? 30.436 21.049 15.869 1.00 18.41 ? 84 ASN A OD1 1 ATOM 637 N ND2 . ASN A 1 84 ? 30.102 18.850 15.631 1.00 10.55 ? 84 ASN A ND2 1 ATOM 638 N N . VAL A 1 85 ? 26.200 21.681 18.065 1.00 14.58 ? 85 VAL A N 1 ATOM 639 C CA . VAL A 1 85 ? 24.905 21.828 18.708 1.00 14.73 ? 85 VAL A CA 1 ATOM 640 C C . VAL A 1 85 ? 24.415 20.449 19.185 1.00 14.77 ? 85 VAL A C 1 ATOM 641 O O . VAL A 1 85 ? 23.902 20.325 20.281 1.00 13.66 ? 85 VAL A O 1 ATOM 642 C CB . VAL A 1 85 ? 23.901 22.528 17.785 1.00 14.71 ? 85 VAL A CB 1 ATOM 643 C CG1 . VAL A 1 85 ? 22.505 22.626 18.430 1.00 14.77 ? 85 VAL A CG1 1 ATOM 644 C CG2 . VAL A 1 85 ? 24.406 23.931 17.423 1.00 14.96 ? 85 VAL A CG2 1 ATOM 645 N N . ASP A 1 86 ? 24.626 19.415 18.372 1.00 15.26 ? 86 ASP A N 1 ATOM 646 C CA . ASP A 1 86 ? 24.075 18.084 18.642 1.00 16.03 ? 86 ASP A CA 1 ATOM 647 C C . ASP A 1 86 ? 25.041 17.091 19.319 1.00 16.66 ? 86 ASP A C 1 ATOM 648 O O . ASP A 1 86 ? 24.594 16.052 19.819 1.00 16.14 ? 86 ASP A O 1 ATOM 649 C CB . ASP A 1 86 ? 23.504 17.473 17.352 1.00 16.14 ? 86 ASP A CB 1 ATOM 650 C CG . ASP A 1 86 ? 24.559 17.243 16.270 1.00 16.90 ? 86 ASP A CG 1 ATOM 651 O OD1 . ASP A 1 86 ? 25.595 17.987 16.185 1.00 14.52 ? 86 ASP A OD1 1 ATOM 652 O OD2 . ASP A 1 86 ? 24.404 16.320 15.445 1.00 16.52 ? 86 ASP A OD2 1 ATOM 653 N N . LYS A 1 87 ? 26.335 17.419 19.372 1.00 16.71 ? 87 LYS A N 1 ATOM 654 C CA . LYS A 1 87 ? 27.353 16.519 19.939 1.00 16.87 ? 87 LYS A CA 1 ATOM 655 C C . LYS A 1 87 ? 28.446 17.279 20.695 1.00 16.97 ? 87 LYS A C 1 ATOM 656 O O . LYS A 1 87 ? 28.942 18.304 20.228 1.00 16.17 ? 87 LYS A O 1 ATOM 657 C CB . LYS A 1 87 ? 27.993 15.667 18.828 1.00 17.40 ? 87 LYS A CB 1 ATOM 658 C CG . LYS A 1 87 ? 26.981 14.826 18.065 1.00 19.00 ? 87 LYS A CG 1 ATOM 659 C CD . LYS A 1 87 ? 27.571 13.540 17.506 1.00 20.39 ? 87 LYS A CD 1 ATOM 660 C CE . LYS A 1 87 ? 26.577 12.843 16.613 1.00 21.81 ? 87 LYS A CE 1 ATOM 661 N NZ . LYS A 1 87 ? 27.258 11.765 15.842 1.00 22.81 ? 87 LYS A NZ 1 ATOM 662 N N . HIS A 1 88 ? 28.827 16.757 21.858 1.00 16.78 ? 88 HIS A N 1 ATOM 663 C CA . HIS A 1 88 ? 29.863 17.380 22.684 1.00 17.28 ? 88 HIS A CA 1 ATOM 664 C C . HIS A 1 88 ? 31.237 17.345 22.034 1.00 16.31 ? 88 HIS A C 1 ATOM 665 O O . HIS A 1 88 ? 32.023 18.284 22.165 1.00 17.58 ? 88 HIS A O 1 ATOM 666 C CB . HIS A 1 88 ? 29.944 16.704 24.050 1.00 17.46 ? 88 HIS A CB 1 ATOM 667 C CG . HIS A 1 88 ? 28.778 16.994 24.942 1.00 18.65 ? 88 HIS A CG 1 ATOM 668 N ND1 . HIS A 1 88 ? 28.398 16.156 25.969 1.00 19.80 ? 88 HIS A ND1 1 ATOM 669 C CD2 . HIS A 1 88 ? 27.910 18.034 24.964 1.00 21.79 ? 88 HIS A CD2 1 ATOM 670 C CE1 . HIS A 1 88 ? 27.346 16.666 26.583 1.00 19.95 ? 88 HIS A CE1 1 ATOM 671 N NE2 . HIS A 1 88 ? 27.029 17.807 25.994 1.00 20.86 ? 88 HIS A NE2 1 ATOM 672 N N . VAL A 1 89 ? 31.536 16.236 21.378 1.00 15.86 ? 89 VAL A N 1 ATOM 673 C CA . VAL A 1 89 ? 32.792 16.066 20.675 1.00 15.25 ? 89 VAL A CA 1 ATOM 674 C C . VAL A 1 89 ? 32.484 16.240 19.184 1.00 15.00 ? 89 VAL A C 1 ATOM 675 O O . VAL A 1 89 ? 31.756 15.434 18.590 1.00 14.95 ? 89 VAL A O 1 ATOM 676 C CB . VAL A 1 89 ? 33.407 14.698 20.962 1.00 15.20 ? 89 VAL A CB 1 ATOM 677 C CG1 . VAL A 1 89 ? 34.719 14.546 20.195 1.00 14.74 ? 89 VAL A CG1 1 ATOM 678 C CG2 . VAL A 1 89 ? 33.627 14.533 22.473 1.00 14.69 ? 89 VAL A CG2 1 ATOM 679 N N . PRO A 1 90 ? 33.008 17.296 18.579 1.00 14.76 ? 90 PRO A N 1 ATOM 680 C CA . PRO A 1 90 ? 32.530 17.720 17.272 1.00 14.54 ? 90 PRO A CA 1 ATOM 681 C C . PRO A 1 90 ? 33.278 17.081 16.096 1.00 14.14 ? 90 PRO A C 1 ATOM 682 O O . PRO A 1 90 ? 34.231 16.309 16.290 1.00 14.17 ? 90 PRO A O 1 ATOM 683 C CB . PRO A 1 90 ? 32.817 19.223 17.314 1.00 14.95 ? 90 PRO A CB 1 ATOM 684 C CG . PRO A 1 90 ? 34.159 19.275 17.986 1.00 14.85 ? 90 PRO A CG 1 ATOM 685 C CD . PRO A 1 90 ? 34.086 18.185 19.056 1.00 15.06 ? 90 PRO A CD 1 ATOM 686 N N . ASP A 1 91 ? 32.820 17.405 14.889 1.00 14.48 ? 91 ASP A N 1 ATOM 687 C CA . ASP A 1 91 ? 33.529 17.099 13.660 1.00 14.15 ? 91 ASP A CA 1 ATOM 688 C C . ASP A 1 91 ? 34.022 18.382 13.009 1.00 14.28 ? 91 ASP A C 1 ATOM 689 O O . ASP A 1 91 ? 33.797 19.496 13.508 1.00 14.83 ? 91 ASP A O 1 ATOM 690 C CB . ASP A 1 91 ? 32.640 16.303 12.686 1.00 14.20 ? 91 ASP A CB 1 ATOM 691 C CG . ASP A 1 91 ? 31.783 17.189 11.823 1.00 15.08 ? 91 ASP A CG 1 ATOM 692 O OD1 . ASP A 1 91 ? 31.848 17.061 10.564 1.00 14.54 ? 91 ASP A OD1 1 ATOM 693 O OD2 . ASP A 1 91 ? 31.037 18.063 12.316 1.00 16.83 ? 91 ASP A OD2 1 HETATM 694 N N . SEP A 1 92 ? 34.718 18.217 11.893 1.00 14.15 ? 92 SEP A N 1 HETATM 695 C CA . SEP A 1 92 ? 35.335 19.340 11.184 1.00 14.34 ? 92 SEP A CA 1 HETATM 696 C CB . SEP A 1 92 ? 36.341 18.818 10.161 1.00 14.10 ? 92 SEP A CB 1 HETATM 697 O OG . SEP A 1 92 ? 37.389 18.134 10.810 1.00 15.26 ? 92 SEP A OG 1 HETATM 698 C C . SEP A 1 92 ? 34.333 20.205 10.444 1.00 13.86 ? 92 SEP A C 1 HETATM 699 O O . SEP A 1 92 ? 34.582 21.398 10.235 1.00 13.75 ? 92 SEP A O 1 HETATM 700 P P . SEP A 1 92 ? 37.532 16.549 10.806 1.00 15.35 ? 92 SEP A P 1 HETATM 701 O O1P . SEP A 1 92 ? 36.248 15.867 11.167 1.00 15.56 ? 92 SEP A O1P 1 HETATM 702 O O2P . SEP A 1 92 ? 37.779 16.296 9.335 1.00 12.80 ? 92 SEP A O2P 1 HETATM 703 O O3P . SEP A 1 92 ? 38.730 16.228 11.754 1.00 14.47 ? 92 SEP A O3P 1 ATOM 704 N N . GLY A 1 93 ? 33.240 19.592 9.991 1.00 13.32 ? 93 GLY A N 1 ATOM 705 C CA . GLY A 1 93 ? 32.226 20.315 9.225 1.00 13.93 ? 93 GLY A CA 1 ATOM 706 C C . GLY A 1 93 ? 31.552 21.354 10.097 1.00 13.91 ? 93 GLY A C 1 ATOM 707 O O . GLY A 1 93 ? 31.558 22.548 9.795 1.00 13.99 ? 93 GLY A O 1 ATOM 708 N N . ALA A 1 94 ? 30.995 20.893 11.211 1.00 14.78 ? 94 ALA A N 1 ATOM 709 C CA . ALA A 1 94 ? 30.191 21.758 12.060 1.00 14.32 ? 94 ALA A CA 1 ATOM 710 C C . ALA A 1 94 ? 31.017 22.744 12.886 1.00 13.79 ? 94 ALA A C 1 ATOM 711 O O . ALA A 1 94 ? 30.556 23.859 13.157 1.00 13.50 ? 94 ALA A O 1 ATOM 712 C CB . ALA A 1 94 ? 29.273 20.929 12.918 1.00 14.82 ? 94 ALA A CB 1 ATOM 713 N N . THR A 1 95 ? 32.253 22.387 13.240 1.00 13.66 ? 95 THR A N 1 ATOM 714 C CA . THR A 1 95 ? 33.173 23.379 13.787 1.00 13.05 ? 95 THR A CA 1 ATOM 715 C C . THR A 1 95 ? 33.542 24.409 12.727 1.00 13.05 ? 95 THR A C 1 ATOM 716 O O . THR A 1 95 ? 33.620 25.571 13.043 1.00 14.36 ? 95 THR A O 1 ATOM 717 C CB . THR A 1 95 ? 34.451 22.739 14.357 1.00 13.30 ? 95 THR A CB 1 ATOM 718 O OG1 . THR A 1 95 ? 35.062 21.887 13.368 1.00 11.98 ? 95 THR A OG1 1 ATOM 719 C CG2 . THR A 1 95 ? 34.125 21.857 15.576 1.00 12.59 ? 95 THR A CG2 1 ATOM 720 N N . ALA A 1 96 ? 33.755 24.003 11.473 1.00 13.02 ? 96 ALA A N 1 ATOM 721 C CA . ALA A 1 96 ? 34.007 24.974 10.391 1.00 12.54 ? 96 ALA A CA 1 ATOM 722 C C . ALA A 1 96 ? 32.912 26.038 10.350 1.00 12.48 ? 96 ALA A C 1 ATOM 723 O O . ALA A 1 96 ? 33.184 27.234 10.230 1.00 12.29 ? 96 ALA A O 1 ATOM 724 C CB . ALA A 1 96 ? 34.125 24.282 9.036 1.00 12.87 ? 96 ALA A CB 1 ATOM 725 N N . THR A 1 97 ? 31.672 25.596 10.446 1.00 12.99 ? 97 THR A N 1 ATOM 726 C CA . THR A 1 97 ? 30.529 26.511 10.432 1.00 12.92 ? 97 THR A CA 1 ATOM 727 C C . THR A 1 97 ? 30.695 27.535 11.542 1.00 12.92 ? 97 THR A C 1 ATOM 728 O O . THR A 1 97 ? 30.464 28.737 11.347 1.00 13.41 ? 97 THR A O 1 ATOM 729 C CB . THR A 1 97 ? 29.240 25.723 10.609 1.00 12.81 ? 97 THR A CB 1 ATOM 730 O OG1 . THR A 1 97 ? 29.159 24.742 9.580 1.00 14.24 ? 97 THR A OG1 1 ATOM 731 C CG2 . THR A 1 97 ? 28.009 26.599 10.389 1.00 13.04 ? 97 THR A CG2 1 ATOM 732 N N . ALA A 1 98 ? 31.111 27.058 12.707 1.00 12.96 ? 98 ALA A N 1 ATOM 733 C CA . ALA A 1 98 ? 31.368 27.944 13.837 1.00 13.27 ? 98 ALA A CA 1 ATOM 734 C C . ALA A 1 98 ? 32.517 28.932 13.600 1.00 13.30 ? 98 ALA A C 1 ATOM 735 O O . ALA A 1 98 ? 32.291 30.134 13.701 1.00 13.51 ? 98 ALA A O 1 ATOM 736 C CB . ALA A 1 98 ? 31.584 27.150 15.106 1.00 13.46 ? 98 ALA A CB 1 ATOM 737 N N . TYR A 1 99 ? 33.735 28.468 13.306 1.00 13.18 ? 99 TYR A N 1 ATOM 738 C CA . TYR A 1 99 ? 34.878 29.402 13.225 1.00 12.87 ? 99 TYR A CA 1 ATOM 739 C C . TYR A 1 99 ? 34.980 30.140 11.880 1.00 13.49 ? 99 TYR A C 1 ATOM 740 O O . TYR A 1 99 ? 35.753 31.088 11.769 1.00 13.84 ? 99 TYR A O 1 ATOM 741 C CB . TYR A 1 99 ? 36.233 28.728 13.610 1.00 12.91 ? 99 TYR A CB 1 ATOM 742 C CG . TYR A 1 99 ? 36.668 27.583 12.720 1.00 11.83 ? 99 TYR A CG 1 ATOM 743 C CD1 . TYR A 1 99 ? 37.298 27.821 11.506 1.00 12.02 ? 99 TYR A CD1 1 ATOM 744 C CD2 . TYR A 1 99 ? 36.433 26.266 13.088 1.00 12.14 ? 99 TYR A CD2 1 ATOM 745 C CE1 . TYR A 1 99 ? 37.688 26.775 10.668 1.00 11.78 ? 99 TYR A CE1 1 ATOM 746 C CE2 . TYR A 1 99 ? 36.808 25.210 12.252 1.00 11.94 ? 99 TYR A CE2 1 ATOM 747 C CZ . TYR A 1 99 ? 37.438 25.474 11.049 1.00 12.27 ? 99 TYR A CZ 1 ATOM 748 O OH . TYR A 1 99 ? 37.809 24.444 10.220 1.00 13.04 ? 99 TYR A OH 1 ATOM 749 N N . LEU A 1 100 ? 34.189 29.733 10.875 1.00 12.90 ? 100 LEU A N 1 ATOM 750 C CA . LEU A 1 100 ? 34.183 30.405 9.582 1.00 12.95 ? 100 LEU A CA 1 ATOM 751 C C . LEU A 1 100 ? 32.907 31.168 9.283 1.00 13.62 ? 100 LEU A C 1 ATOM 752 O O . LEU A 1 100 ? 32.968 32.164 8.580 1.00 14.55 ? 100 LEU A O 1 ATOM 753 C CB . LEU A 1 100 ? 34.449 29.414 8.442 1.00 12.51 ? 100 LEU A CB 1 ATOM 754 C CG . LEU A 1 100 ? 35.780 28.679 8.504 1.00 13.13 ? 100 LEU A CG 1 ATOM 755 C CD1 . LEU A 1 100 ? 35.858 27.650 7.396 1.00 11.43 ? 100 LEU A CD1 1 ATOM 756 C CD2 . LEU A 1 100 ? 36.947 29.652 8.416 1.00 14.22 ? 100 LEU A CD2 1 ATOM 757 N N . CYS A 1 101 ? 31.766 30.697 9.790 1.00 13.97 ? 101 CYS A N 1 ATOM 758 C CA . CYS A 1 101 ? 30.468 31.360 9.571 1.00 14.27 ? 101 CYS A CA 1 ATOM 759 C C . CYS A 1 101 ? 29.891 32.010 10.825 1.00 14.45 ? 101 CYS A C 1 ATOM 760 O O . CYS A 1 101 ? 28.995 32.844 10.714 1.00 14.15 ? 101 CYS A O 1 ATOM 761 C CB . CYS A 1 101 ? 29.467 30.373 8.957 1.00 14.22 ? 101 CYS A CB 1 ATOM 762 S SG . CYS A 1 101 ? 30.145 29.533 7.511 1.00 15.49 ? 101 CYS A SG 1 ATOM 763 N N . GLY A 1 102 ? 30.421 31.665 12.003 1.00 14.33 ? 102 GLY A N 1 ATOM 764 C CA . GLY A 1 102 ? 30.031 32.303 13.263 1.00 14.36 ? 102 GLY A CA 1 ATOM 765 C C . GLY A 1 102 ? 28.735 31.773 13.867 1.00 14.38 ? 102 GLY A C 1 ATOM 766 O O . GLY A 1 102 ? 28.082 32.438 14.664 1.00 14.14 ? 102 GLY A O 1 ATOM 767 N N . VAL A 1 103 ? 28.382 30.558 13.492 1.00 13.89 ? 103 VAL A N 1 ATOM 768 C CA . VAL A 1 103 ? 27.150 29.929 13.918 1.00 14.11 ? 103 VAL A CA 1 ATOM 769 C C . VAL A 1 103 ? 27.482 28.473 14.137 1.00 14.44 ? 103 VAL A C 1 ATOM 770 O O . VAL A 1 103 ? 28.199 27.893 13.333 1.00 14.17 ? 103 VAL A O 1 ATOM 771 C CB . VAL A 1 103 ? 26.085 30.102 12.823 1.00 14.18 ? 103 VAL A CB 1 ATOM 772 C CG1 . VAL A 1 103 ? 24.825 29.273 13.117 1.00 15.19 ? 103 VAL A CG1 1 ATOM 773 C CG2 . VAL A 1 103 ? 25.771 31.569 12.693 1.00 14.29 ? 103 VAL A CG2 1 ATOM 774 N N . LYS A 1 104 ? 27.022 27.899 15.246 1.00 14.43 ? 104 LYS A N 1 ATOM 775 C CA . LYS A 1 104 ? 27.235 26.483 15.459 1.00 14.59 ? 104 LYS A CA 1 ATOM 776 C C . LYS A 1 104 ? 26.182 25.713 14.677 1.00 14.48 ? 104 LYS A C 1 ATOM 777 O O . LYS A 1 104 ? 25.070 26.209 14.424 1.00 14.30 ? 104 LYS A O 1 ATOM 778 C CB . LYS A 1 104 ? 27.225 26.105 16.937 1.00 14.29 ? 104 LYS A CB 1 ATOM 779 C CG . LYS A 1 104 ? 28.361 26.780 17.720 1.00 14.70 ? 104 LYS A CG 1 ATOM 780 C CD . LYS A 1 104 ? 28.796 25.929 18.905 1.00 13.08 ? 104 LYS A CD 1 ATOM 781 C CE . LYS A 1 104 ? 30.158 26.327 19.410 1.00 11.81 ? 104 LYS A CE 1 ATOM 782 N NZ . LYS A 1 104 ? 30.513 25.503 20.624 1.00 9.09 ? 104 LYS A NZ 1 ATOM 783 N N . GLY A 1 105 ? 26.563 24.513 14.268 1.00 14.48 ? 105 GLY A N 1 ATOM 784 C CA . GLY A 1 105 ? 25.694 23.635 13.483 1.00 14.23 ? 105 GLY A CA 1 ATOM 785 C C . GLY A 1 105 ? 25.797 22.216 13.997 1.00 14.50 ? 105 GLY A C 1 ATOM 786 O O . GLY A 1 105 ? 26.459 21.945 15.005 1.00 14.63 ? 105 GLY A O 1 ATOM 787 N N . ASN A 1 106 ? 25.118 21.313 13.306 1.00 14.87 ? 106 ASN A N 1 ATOM 788 C CA . ASN A 1 106 ? 25.095 19.914 13.678 1.00 14.72 ? 106 ASN A CA 1 ATOM 789 C C . ASN A 1 106 ? 26.198 19.164 12.971 1.00 15.23 ? 106 ASN A C 1 ATOM 790 O O . ASN A 1 106 ? 26.536 19.447 11.819 1.00 15.18 ? 106 ASN A O 1 ATOM 791 C CB . ASN A 1 106 ? 23.729 19.281 13.372 1.00 14.72 ? 106 ASN A CB 1 ATOM 792 C CG . ASN A 1 106 ? 22.614 19.897 14.197 1.00 14.91 ? 106 ASN A CG 1 ATOM 793 O OD1 . ASN A 1 106 ? 22.764 20.105 15.411 1.00 13.76 ? 106 ASN A OD1 1 ATOM 794 N ND2 . ASN A 1 106 ? 21.494 20.196 13.549 1.00 14.25 ? 106 ASN A ND2 1 ATOM 795 N N . PHE A 1 107 ? 26.784 18.250 13.735 1.00 16.05 ? 107 PHE A N 1 ATOM 796 C CA . PHE A 1 107 ? 27.754 17.248 13.302 1.00 16.27 ? 107 PHE A CA 1 ATOM 797 C C . PHE A 1 107 ? 27.588 16.815 11.833 1.00 16.76 ? 107 PHE A C 1 ATOM 798 O O . PHE A 1 107 ? 26.510 16.385 11.420 1.00 16.25 ? 107 PHE A O 1 ATOM 799 C CB . PHE A 1 107 ? 27.563 16.046 14.222 1.00 16.25 ? 107 PHE A CB 1 ATOM 800 C CG . PHE A 1 107 ? 28.754 15.136 14.343 1.00 16.16 ? 107 PHE A CG 1 ATOM 801 C CD1 . PHE A 1 107 ? 28.768 13.917 13.686 1.00 14.96 ? 107 PHE A CD1 1 ATOM 802 C CD2 . PHE A 1 107 ? 29.821 15.463 15.181 1.00 16.81 ? 107 PHE A CD2 1 ATOM 803 C CE1 . PHE A 1 107 ? 29.839 13.052 13.830 1.00 16.09 ? 107 PHE A CE1 1 ATOM 804 C CE2 . PHE A 1 107 ? 30.900 14.604 15.338 1.00 16.49 ? 107 PHE A CE2 1 ATOM 805 C CZ . PHE A 1 107 ? 30.906 13.395 14.667 1.00 16.47 ? 107 PHE A CZ 1 ATOM 806 N N . GLN A 1 108 ? 28.681 16.943 11.073 1.00 17.42 ? 108 GLN A N 1 ATOM 807 C CA . GLN A 1 108 ? 28.833 16.470 9.682 1.00 17.78 ? 108 GLN A CA 1 ATOM 808 C C . GLN A 1 108 ? 28.140 17.326 8.608 1.00 17.28 ? 108 GLN A C 1 ATOM 809 O O . GLN A 1 108 ? 28.227 17.010 7.413 1.00 17.49 ? 108 GLN A O 1 ATOM 810 C CB . GLN A 1 108 ? 28.491 14.972 9.538 1.00 18.17 ? 108 GLN A CB 1 ATOM 811 C CG . GLN A 1 108 ? 29.542 14.055 10.126 1.00 19.56 ? 108 GLN A CG 1 ATOM 812 C CD . GLN A 1 108 ? 29.231 12.573 9.919 1.00 20.55 ? 108 GLN A CD 1 ATOM 813 O OE1 . GLN A 1 108 ? 28.183 12.095 10.321 1.00 26.61 ? 108 GLN A OE1 1 ATOM 814 N NE2 . GLN A 1 108 ? 30.155 11.853 9.310 1.00 27.76 ? 108 GLN A NE2 1 ATOM 815 N N . THR A 1 109 ? 27.488 18.408 9.023 1.00 16.89 ? 109 THR A N 1 ATOM 816 C CA . THR A 1 109 ? 27.025 19.437 8.098 1.00 16.17 ? 109 THR A CA 1 ATOM 817 C C . THR A 1 109 ? 28.060 20.544 8.030 1.00 15.79 ? 109 THR A C 1 ATOM 818 O O . THR A 1 109 ? 28.914 20.673 8.919 1.00 15.65 ? 109 THR A O 1 ATOM 819 C CB . THR A 1 109 ? 25.655 20.036 8.521 1.00 16.40 ? 109 THR A CB 1 ATOM 820 O OG1 . THR A 1 109 ? 25.797 20.804 9.722 1.00 15.10 ? 109 THR A OG1 1 ATOM 821 C CG2 . THR A 1 109 ? 24.627 18.937 8.859 1.00 15.69 ? 109 THR A CG2 1 ATOM 822 N N . ILE A 1 110 ? 27.972 21.334 6.966 1.00 15.19 ? 110 ILE A N 1 ATOM 823 C CA . ILE A 1 110 ? 28.884 22.452 6.713 1.00 15.13 ? 110 ILE A CA 1 ATOM 824 C C . ILE A 1 110 ? 28.127 23.689 6.262 1.00 15.22 ? 110 ILE A C 1 ATOM 825 O O . ILE A 1 110 ? 27.309 23.628 5.340 1.00 15.33 ? 110 ILE A O 1 ATOM 826 C CB . ILE A 1 110 ? 29.871 22.115 5.587 1.00 14.57 ? 110 ILE A CB 1 ATOM 827 C CG1 . ILE A 1 110 ? 30.612 20.803 5.863 1.00 13.96 ? 110 ILE A CG1 1 ATOM 828 C CG2 . ILE A 1 110 ? 30.826 23.315 5.367 1.00 14.69 ? 110 ILE A CG2 1 ATOM 829 C CD1 . ILE A 1 110 ? 31.478 20.355 4.731 1.00 13.97 ? 110 ILE A CD1 1 ATOM 830 N N . GLY A 1 111 ? 28.452 24.823 6.864 1.00 15.38 ? 111 GLY A N 1 ATOM 831 C CA . GLY A 1 111 ? 27.882 26.110 6.469 1.00 15.46 ? 111 GLY A CA 1 ATOM 832 C C . GLY A 1 111 ? 26.373 26.197 6.608 1.00 15.46 ? 111 GLY A C 1 ATOM 833 O O . GLY A 1 111 ? 25.727 26.963 5.886 1.00 15.28 ? 111 GLY A O 1 ATOM 834 N N . LEU A 1 112 ? 25.813 25.408 7.522 1.00 15.43 ? 112 LEU A N 1 ATOM 835 C CA . LEU A 1 112 ? 24.372 25.407 7.787 1.00 15.04 ? 112 LEU A CA 1 ATOM 836 C C . LEU A 1 112 ? 24.097 25.566 9.277 1.00 14.88 ? 112 LEU A C 1 ATOM 837 O O . LEU A 1 112 ? 24.852 25.075 10.119 1.00 13.89 ? 112 LEU A O 1 ATOM 838 C CB . LEU A 1 112 ? 23.723 24.097 7.326 1.00 15.35 ? 112 LEU A CB 1 ATOM 839 C CG . LEU A 1 112 ? 23.787 23.741 5.842 1.00 14.71 ? 112 LEU A CG 1 ATOM 840 C CD1 . LEU A 1 112 ? 23.355 22.305 5.644 1.00 14.78 ? 112 LEU A CD1 1 ATOM 841 C CD2 . LEU A 1 112 ? 22.931 24.682 5.008 1.00 14.81 ? 112 LEU A CD2 1 ATOM 842 N N . SER A 1 113 ? 22.998 26.240 9.599 1.00 14.36 ? 113 SER A N 1 ATOM 843 C CA . SER A 1 113 ? 22.578 26.374 10.982 1.00 14.40 ? 113 SER A CA 1 ATOM 844 C C . SER A 1 113 ? 22.120 25.006 11.462 1.00 14.27 ? 113 SER A C 1 ATOM 845 O O . SER A 1 113 ? 21.940 24.074 10.661 1.00 13.90 ? 113 SER A O 1 ATOM 846 C CB . SER A 1 113 ? 21.425 27.377 11.128 1.00 14.47 ? 113 SER A CB 1 ATOM 847 O OG . SER A 1 113 ? 20.223 26.807 10.659 1.00 15.55 ? 113 SER A OG 1 ATOM 848 N N . ALA A 1 114 ? 21.903 24.911 12.767 1.00 13.64 ? 114 ALA A N 1 ATOM 849 C CA . ALA A 1 114 ? 21.506 23.659 13.388 1.00 13.79 ? 114 ALA A CA 1 ATOM 850 C C . ALA A 1 114 ? 20.025 23.328 13.181 1.00 14.20 ? 114 ALA A C 1 ATOM 851 O O . ALA A 1 114 ? 19.525 22.385 13.759 1.00 13.62 ? 114 ALA A O 1 ATOM 852 C CB . ALA A 1 114 ? 21.882 23.667 14.869 1.00 13.28 ? 114 ALA A CB 1 ATOM 853 N N . ALA A 1 115 ? 19.337 24.097 12.341 1.00 14.89 ? 115 ALA A N 1 ATOM 854 C CA . ALA A 1 115 ? 17.983 23.763 11.921 1.00 14.81 ? 115 ALA A CA 1 ATOM 855 C C . ALA A 1 115 ? 18.049 22.708 10.824 1.00 15.35 ? 115 ALA A C 1 ATOM 856 O O . ALA A 1 115 ? 17.093 21.983 10.604 1.00 15.32 ? 115 ALA A O 1 ATOM 857 C CB . ALA A 1 115 ? 17.250 25.018 11.432 1.00 15.01 ? 115 ALA A CB 1 ATOM 858 N N . ALA A 1 116 ? 19.188 22.614 10.147 1.00 15.36 ? 116 ALA A N 1 ATOM 859 C CA . ALA A 1 116 ? 19.396 21.587 9.138 1.00 15.77 ? 116 ALA A CA 1 ATOM 860 C C . ALA A 1 116 ? 19.663 20.262 9.837 1.00 15.80 ? 116 ALA A C 1 ATOM 861 O O . ALA A 1 116 ? 19.999 20.223 11.023 1.00 16.05 ? 116 ALA A O 1 ATOM 862 C CB . ALA A 1 116 ? 20.563 21.952 8.213 1.00 15.84 ? 116 ALA A CB 1 ATOM 863 N N . ARG A 1 117 ? 19.534 19.176 9.090 1.00 15.83 ? 117 ARG A N 1 ATOM 864 C CA . ARG A 1 117 ? 19.826 17.860 9.635 1.00 15.53 ? 117 ARG A CA 1 ATOM 865 C C . ARG A 1 117 ? 20.743 17.144 8.688 1.00 15.68 ? 117 ARG A C 1 ATOM 866 O O . ARG A 1 117 ? 20.627 17.297 7.469 1.00 15.41 ? 117 ARG A O 1 ATOM 867 C CB . ARG A 1 117 ? 18.541 17.080 9.830 1.00 15.58 ? 117 ARG A CB 1 ATOM 868 C CG . ARG A 1 117 ? 17.657 17.672 10.910 1.00 16.18 ? 117 ARG A CG 1 ATOM 869 C CD . ARG A 1 117 ? 18.166 17.403 12.307 1.00 16.81 ? 117 ARG A CD 1 ATOM 870 N NE . ARG A 1 117 ? 17.250 17.887 13.330 1.00 15.77 ? 117 ARG A NE 1 ATOM 871 C CZ . ARG A 1 117 ? 17.233 19.119 13.820 1.00 14.97 ? 117 ARG A CZ 1 ATOM 872 N NH1 . ARG A 1 117 ? 18.059 20.052 13.393 1.00 15.43 ? 117 ARG A NH1 1 ATOM 873 N NH2 . ARG A 1 117 ? 16.356 19.433 14.749 1.00 16.96 ? 117 ARG A NH2 1 ATOM 874 N N . PHE A 1 118 ? 21.661 16.368 9.261 1.00 15.82 ? 118 PHE A N 1 ATOM 875 C CA . PHE A 1 118 ? 22.681 15.679 8.495 1.00 16.33 ? 118 PHE A CA 1 ATOM 876 C C . PHE A 1 118 ? 22.004 14.755 7.492 1.00 16.59 ? 118 PHE A C 1 ATOM 877 O O . PHE A 1 118 ? 21.021 14.095 7.811 1.00 17.34 ? 118 PHE A O 1 ATOM 878 C CB . PHE A 1 118 ? 23.614 14.888 9.433 1.00 16.60 ? 118 PHE A CB 1 ATOM 879 C CG . PHE A 1 118 ? 24.469 13.878 8.730 1.00 16.74 ? 118 PHE A CG 1 ATOM 880 C CD1 . PHE A 1 118 ? 25.544 14.276 7.966 1.00 17.62 ? 118 PHE A CD1 1 ATOM 881 C CD2 . PHE A 1 118 ? 24.194 12.520 8.839 1.00 18.14 ? 118 PHE A CD2 1 ATOM 882 C CE1 . PHE A 1 118 ? 26.332 13.343 7.321 1.00 17.00 ? 118 PHE A CE1 1 ATOM 883 C CE2 . PHE A 1 118 ? 24.969 11.599 8.202 1.00 17.99 ? 118 PHE A CE2 1 ATOM 884 C CZ . PHE A 1 118 ? 26.041 12.008 7.440 1.00 18.25 ? 118 PHE A CZ 1 ATOM 885 N N . ASN A 1 119 ? 22.522 14.757 6.278 1.00 17.14 ? 119 ASN A N 1 ATOM 886 C CA . ASN A 1 119 ? 22.091 13.873 5.211 1.00 16.85 ? 119 ASN A CA 1 ATOM 887 C C . ASN A 1 119 ? 20.606 14.011 4.833 1.00 17.33 ? 119 ASN A C 1 ATOM 888 O O . ASN A 1 119 ? 20.039 13.080 4.289 1.00 16.66 ? 119 ASN A O 1 ATOM 889 C CB . ASN A 1 119 ? 22.405 12.420 5.595 1.00 17.19 ? 119 ASN A CB 1 ATOM 890 C CG . ASN A 1 119 ? 22.481 11.504 4.401 1.00 16.78 ? 119 ASN A CG 1 ATOM 891 O OD1 . ASN A 1 119 ? 22.894 11.908 3.320 1.00 17.38 ? 119 ASN A OD1 1 ATOM 892 N ND2 . ASN A 1 119 ? 22.086 10.241 4.596 1.00 21.47 ? 119 ASN A ND2 1 ATOM 893 N N . GLN A 1 120 ? 19.990 15.154 5.134 1.00 17.10 ? 120 GLN A N 1 ATOM 894 C CA . GLN A 1 120 ? 18.595 15.418 4.752 1.00 18.08 ? 120 GLN A CA 1 ATOM 895 C C . GLN A 1 120 ? 18.598 16.679 3.920 1.00 17.26 ? 120 GLN A C 1 ATOM 896 O O . GLN A 1 120 ? 18.464 17.777 4.446 1.00 17.10 ? 120 GLN A O 1 ATOM 897 C CB . GLN A 1 120 ? 17.680 15.566 5.968 1.00 17.76 ? 120 GLN A CB 1 ATOM 898 C CG . GLN A 1 120 ? 17.543 14.280 6.787 1.00 20.04 ? 120 GLN A CG 1 ATOM 899 C CD . GLN A 1 120 ? 16.713 14.470 8.044 1.00 21.02 ? 120 GLN A CD 1 ATOM 900 O OE1 . GLN A 1 120 ? 15.810 15.308 8.079 1.00 25.96 ? 120 GLN A OE1 1 ATOM 901 N NE2 . GLN A 1 120 ? 17.010 13.689 9.083 1.00 23.18 ? 120 GLN A NE2 1 ATOM 902 N N . CYS A 1 121 ? 18.776 16.487 2.616 1.00 17.32 ? 121 CYS A N 1 ATOM 903 C CA . CYS A 1 121 ? 18.878 17.563 1.649 1.00 17.14 ? 121 CYS A CA 1 ATOM 904 C C . CYS A 1 121 ? 17.753 18.587 1.789 1.00 16.78 ? 121 CYS A C 1 ATOM 905 O O . CYS A 1 121 ? 17.973 19.797 1.660 1.00 15.51 ? 121 CYS A O 1 ATOM 906 C CB . CYS A 1 121 ? 18.865 16.980 0.233 1.00 17.40 ? 121 CYS A CB 1 ATOM 907 S SG . CYS A 1 121 ? 18.904 18.232 -1.050 1.00 19.03 ? 121 CYS A SG 1 ATOM 908 N N . ASN A 1 122 ? 16.557 18.090 2.080 1.00 17.02 ? 122 ASN A N 1 ATOM 909 C CA . ASN A 1 122 ? 15.371 18.937 2.173 1.00 17.62 ? 122 ASN A CA 1 ATOM 910 C C . ASN A 1 122 ? 15.264 19.756 3.463 1.00 17.42 ? 122 ASN A C 1 ATOM 911 O O . ASN A 1 122 ? 14.257 20.439 3.677 1.00 17.46 ? 122 ASN A O 1 ATOM 912 C CB . ASN A 1 122 ? 14.110 18.093 1.934 1.00 18.10 ? 122 ASN A CB 1 ATOM 913 C CG . ASN A 1 122 ? 13.834 17.116 3.048 1.00 19.93 ? 122 ASN A CG 1 ATOM 914 O OD1 . ASN A 1 122 ? 14.620 16.988 3.996 1.00 22.23 ? 122 ASN A OD1 1 ATOM 915 N ND2 . ASN A 1 122 ? 12.696 16.417 2.941 1.00 23.08 ? 122 ASN A ND2 1 ATOM 916 N N . THR A 1 123 ? 16.297 19.696 4.321 1.00 16.82 ? 123 THR A N 1 ATOM 917 C CA . THR A 1 123 ? 16.410 20.610 5.459 1.00 16.60 ? 123 THR A CA 1 ATOM 918 C C . THR A 1 123 ? 17.460 21.697 5.217 1.00 16.57 ? 123 THR A C 1 ATOM 919 O O . THR A 1 123 ? 17.838 22.388 6.156 1.00 16.96 ? 123 THR A O 1 ATOM 920 C CB . THR A 1 123 ? 16.754 19.853 6.765 1.00 16.61 ? 123 THR A CB 1 ATOM 921 O OG1 . THR A 1 123 ? 18.034 19.207 6.648 1.00 16.95 ? 123 THR A OG1 1 ATOM 922 C CG2 . THR A 1 123 ? 15.761 18.743 7.029 1.00 16.13 ? 123 THR A CG2 1 ATOM 923 N N . THR A 1 124 ? 17.920 21.856 3.973 1.00 16.18 ? 124 THR A N 1 ATOM 924 C CA . THR A 1 124 ? 19.018 22.782 3.683 1.00 16.25 ? 124 THR A CA 1 ATOM 925 C C . THR A 1 124 ? 18.562 24.225 3.625 1.00 16.51 ? 124 THR A C 1 ATOM 926 O O . THR A 1 124 ? 19.096 25.098 4.314 1.00 16.07 ? 124 THR A O 1 ATOM 927 C CB . THR A 1 124 ? 19.679 22.444 2.335 1.00 16.22 ? 124 THR A CB 1 ATOM 928 O OG1 . THR A 1 124 ? 20.160 21.095 2.339 1.00 16.75 ? 124 THR A OG1 1 ATOM 929 C CG2 . THR A 1 124 ? 20.932 23.299 2.114 1.00 16.93 ? 124 THR A CG2 1 ATOM 930 N N . ARG A 1 125 ? 17.564 24.478 2.785 1.00 17.02 ? 125 ARG A N 1 ATOM 931 C CA . ARG A 1 125 ? 17.258 25.833 2.377 1.00 17.26 ? 125 ARG A CA 1 ATOM 932 C C . ARG A 1 125 ? 16.659 26.694 3.483 1.00 17.47 ? 125 ARG A C 1 ATOM 933 O O . ARG A 1 125 ? 15.780 26.259 4.213 1.00 17.62 ? 125 ARG A O 1 ATOM 934 C CB . ARG A 1 125 ? 16.370 25.805 1.148 1.00 17.69 ? 125 ARG A CB 1 ATOM 935 C CG . ARG A 1 125 ? 17.118 25.320 -0.071 1.00 19.19 ? 125 ARG A CG 1 ATOM 936 C CD . ARG A 1 125 ? 16.556 25.914 -1.319 1.00 22.16 ? 125 ARG A CD 1 ATOM 937 N NE . ARG A 1 125 ? 17.264 25.545 -2.532 1.00 22.16 ? 125 ARG A NE 1 ATOM 938 C CZ . ARG A 1 125 ? 16.872 25.953 -3.735 1.00 22.13 ? 125 ARG A CZ 1 ATOM 939 N NH1 . ARG A 1 125 ? 15.804 26.728 -3.865 1.00 23.36 ? 125 ARG A NH1 1 ATOM 940 N NH2 . ARG A 1 125 ? 17.539 25.593 -4.804 1.00 22.99 ? 125 ARG A NH2 1 ATOM 941 N N . GLY A 1 126 ? 17.166 27.921 3.584 1.00 18.07 ? 126 GLY A N 1 ATOM 942 C CA . GLY A 1 126 ? 16.863 28.828 4.694 1.00 18.33 ? 126 GLY A CA 1 ATOM 943 C C . GLY A 1 126 ? 17.912 28.755 5.795 1.00 18.47 ? 126 GLY A C 1 ATOM 944 O O . GLY A 1 126 ? 18.000 29.648 6.628 1.00 18.81 ? 126 GLY A O 1 ATOM 945 N N . ASN A 1 127 ? 18.730 27.708 5.789 1.00 18.51 ? 127 ASN A N 1 ATOM 946 C CA . ASN A 1 127 ? 19.652 27.452 6.901 1.00 18.27 ? 127 ASN A CA 1 ATOM 947 C C . ASN A 1 127 ? 21.106 27.684 6.530 1.00 18.34 ? 127 ASN A C 1 ATOM 948 O O . ASN A 1 127 ? 21.996 27.432 7.332 1.00 18.07 ? 127 ASN A O 1 ATOM 949 C CB . ASN A 1 127 ? 19.450 26.030 7.411 1.00 18.82 ? 127 ASN A CB 1 ATOM 950 C CG . ASN A 1 127 ? 18.041 25.796 7.904 1.00 18.74 ? 127 ASN A CG 1 ATOM 951 O OD1 . ASN A 1 127 ? 17.454 24.731 7.678 1.00 19.90 ? 127 ASN A OD1 1 ATOM 952 N ND2 . ASN A 1 127 ? 17.491 26.788 8.591 1.00 15.82 ? 127 ASN A ND2 1 ATOM 953 N N . GLU A 1 128 ? 21.330 28.191 5.317 1.00 17.78 ? 128 GLU A N 1 ATOM 954 C CA . GLU A 1 128 ? 22.652 28.534 4.859 1.00 17.79 ? 128 GLU A CA 1 ATOM 955 C C . GLU A 1 128 ? 23.151 29.682 5.714 1.00 18.11 ? 128 GLU A C 1 ATOM 956 O O . GLU A 1 128 ? 22.438 30.666 5.908 1.00 17.63 ? 128 GLU A O 1 ATOM 957 C CB . GLU A 1 128 ? 22.650 28.961 3.385 1.00 17.99 ? 128 GLU A CB 1 ATOM 958 C CG . GLU A 1 128 ? 22.210 27.876 2.399 1.00 17.91 ? 128 GLU A CG 1 ATOM 959 C CD . GLU A 1 128 ? 20.710 27.896 2.102 1.00 18.90 ? 128 GLU A CD 1 ATOM 960 O OE1 . GLU A 1 128 ? 19.950 28.605 2.812 1.00 16.52 ? 128 GLU A OE1 1 ATOM 961 O OE2 . GLU A 1 128 ? 20.288 27.182 1.157 1.00 18.57 ? 128 GLU A OE2 1 ATOM 962 N N . VAL A 1 129 ? 24.368 29.547 6.231 1.00 17.83 ? 129 VAL A N 1 ATOM 963 C CA . VAL A 1 129 ? 25.035 30.662 6.909 1.00 17.71 ? 129 VAL A CA 1 ATOM 964 C C . VAL A 1 129 ? 26.309 31.001 6.151 1.00 17.43 ? 129 VAL A C 1 ATOM 965 O O . VAL A 1 129 ? 27.104 30.122 5.832 1.00 16.42 ? 129 VAL A O 1 ATOM 966 C CB . VAL A 1 129 ? 25.298 30.376 8.394 1.00 17.78 ? 129 VAL A CB 1 ATOM 967 C CG1 . VAL A 1 129 ? 23.975 30.251 9.111 1.00 18.87 ? 129 VAL A CG1 1 ATOM 968 C CG2 . VAL A 1 129 ? 26.125 29.121 8.601 1.00 19.31 ? 129 VAL A CG2 1 ATOM 969 N N . ILE A 1 130 ? 26.464 32.287 5.856 1.00 16.92 ? 130 ILE A N 1 ATOM 970 C CA . ILE A 1 130 ? 27.497 32.781 4.958 1.00 17.46 ? 130 ILE A CA 1 ATOM 971 C C . ILE A 1 130 ? 28.805 32.998 5.721 1.00 16.35 ? 130 ILE A C 1 ATOM 972 O O . ILE A 1 130 ? 28.818 33.574 6.807 1.00 15.76 ? 130 ILE A O 1 ATOM 973 C CB . ILE A 1 130 ? 27.013 34.109 4.290 1.00 17.72 ? 130 ILE A CB 1 ATOM 974 C CG1 . ILE A 1 130 ? 25.683 33.916 3.549 1.00 19.33 ? 130 ILE A CG1 1 ATOM 975 C CG2 . ILE A 1 130 ? 28.051 34.654 3.333 1.00 18.81 ? 130 ILE A CG2 1 ATOM 976 C CD1 . ILE A 1 130 ? 25.593 32.643 2.755 1.00 21.07 ? 130 ILE A CD1 1 ATOM 977 N N . SER A 1 131 ? 29.905 32.526 5.145 1.00 16.04 ? 131 SER A N 1 ATOM 978 C CA . SER A 1 131 ? 31.205 32.584 5.801 1.00 15.46 ? 131 SER A CA 1 ATOM 979 C C . SER A 1 131 ? 31.771 33.988 5.784 1.00 15.67 ? 131 SER A C 1 ATOM 980 O O . SER A 1 131 ? 31.393 34.805 4.949 1.00 15.48 ? 131 SER A O 1 ATOM 981 C CB . SER A 1 131 ? 32.198 31.634 5.119 1.00 15.34 ? 131 SER A CB 1 ATOM 982 O OG . SER A 1 131 ? 32.750 32.219 3.950 1.00 16.28 ? 131 SER A OG 1 ATOM 983 N N . VAL A 1 132 ? 32.695 34.266 6.696 1.00 15.47 ? 132 VAL A N 1 ATOM 984 C CA . VAL A 1 132 ? 33.358 35.571 6.663 1.00 16.10 ? 132 VAL A CA 1 ATOM 985 C C . VAL A 1 132 ? 34.227 35.695 5.406 1.00 15.50 ? 132 VAL A C 1 ATOM 986 O O . VAL A 1 132 ? 34.387 36.788 4.908 1.00 14.79 ? 132 VAL A O 1 ATOM 987 C CB . VAL A 1 132 ? 34.075 36.014 8.016 1.00 16.44 ? 132 VAL A CB 1 ATOM 988 C CG1 . VAL A 1 132 ? 34.039 34.947 9.101 1.00 18.27 ? 132 VAL A CG1 1 ATOM 989 C CG2 . VAL A 1 132 ? 35.472 36.580 7.809 1.00 16.03 ? 132 VAL A CG2 1 ATOM 990 N N . MET A 1 133 ? 34.734 34.582 4.863 1.00 15.81 ? 133 MET A N 1 ATOM 991 C CA . MET A 1 133 ? 35.427 34.641 3.571 1.00 16.03 ? 133 MET A CA 1 ATOM 992 C C . MET A 1 133 ? 34.510 35.142 2.449 1.00 16.22 ? 133 MET A C 1 ATOM 993 O O . MET A 1 133 ? 34.910 35.967 1.611 1.00 16.86 ? 133 MET A O 1 ATOM 994 C CB . MET A 1 133 ? 35.987 33.273 3.168 1.00 16.21 ? 133 MET A CB 1 ATOM 995 C CG . MET A 1 133 ? 36.940 33.401 1.983 1.00 16.90 ? 133 MET A CG 1 ATOM 996 S SD . MET A 1 133 ? 37.740 31.882 1.470 1.00 15.91 ? 133 MET A SD 1 ATOM 997 C CE . MET A 1 133 ? 36.413 31.164 0.485 1.00 16.60 ? 133 MET A CE 1 ATOM 998 N N . ASN A 1 134 ? 33.297 34.611 2.406 1.00 16.02 ? 134 ASN A N 1 ATOM 999 C CA . ASN A 1 134 ? 32.297 35.061 1.452 1.00 16.27 ? 134 ASN A CA 1 ATOM 1000 C C . ASN A 1 134 ? 32.055 36.563 1.622 1.00 15.86 ? 134 ASN A C 1 ATOM 1001 O O . ASN A 1 134 ? 32.039 37.334 0.659 1.00 15.58 ? 134 ASN A O 1 ATOM 1002 C CB . ASN A 1 134 ? 31.002 34.274 1.657 1.00 16.34 ? 134 ASN A CB 1 ATOM 1003 C CG . ASN A 1 134 ? 29.934 34.633 0.649 1.00 17.49 ? 134 ASN A CG 1 ATOM 1004 O OD1 . ASN A 1 134 ? 29.601 33.841 -0.235 1.00 18.25 ? 134 ASN A OD1 1 ATOM 1005 N ND2 . ASN A 1 134 ? 29.396 35.834 0.772 1.00 16.34 ? 134 ASN A ND2 1 ATOM 1006 N N . ARG A 1 135 ? 31.885 36.972 2.868 1.00 16.61 ? 135 ARG A N 1 ATOM 1007 C CA . ARG A 1 135 ? 31.634 38.363 3.177 1.00 16.64 ? 135 ARG A CA 1 ATOM 1008 C C . ARG A 1 135 ? 32.835 39.250 2.841 1.00 16.98 ? 135 ARG A C 1 ATOM 1009 O O . ARG A 1 135 ? 32.646 40.379 2.397 1.00 17.29 ? 135 ARG A O 1 ATOM 1010 C CB . ARG A 1 135 ? 31.213 38.507 4.632 1.00 17.10 ? 135 ARG A CB 1 ATOM 1011 C CG . ARG A 1 135 ? 29.842 37.897 4.919 1.00 16.92 ? 135 ARG A CG 1 ATOM 1012 C CD . ARG A 1 135 ? 29.514 37.851 6.397 1.00 18.18 ? 135 ARG A CD 1 ATOM 1013 N NE . ARG A 1 135 ? 29.655 36.512 6.982 1.00 19.51 ? 135 ARG A NE 1 ATOM 1014 C CZ . ARG A 1 135 ? 29.958 36.269 8.260 1.00 19.34 ? 135 ARG A CZ 1 ATOM 1015 N NH1 . ARG A 1 135 ? 30.035 35.026 8.718 1.00 18.49 ? 135 ARG A NH1 1 ATOM 1016 N NH2 . ARG A 1 135 ? 30.193 37.263 9.091 1.00 20.19 ? 135 ARG A NH2 1 ATOM 1017 N N . ALA A 1 136 ? 34.055 38.745 3.039 1.00 17.00 ? 136 ALA A N 1 ATOM 1018 C CA . ALA A 1 136 ? 35.270 39.453 2.598 1.00 17.48 ? 136 ALA A CA 1 ATOM 1019 C C . ALA A 1 136 ? 35.291 39.657 1.085 1.00 17.59 ? 136 ALA A C 1 ATOM 1020 O O . ALA A 1 136 ? 35.644 40.721 0.595 1.00 17.59 ? 136 ALA A O 1 ATOM 1021 C CB . ALA A 1 136 ? 36.522 38.687 3.038 1.00 17.81 ? 136 ALA A CB 1 ATOM 1022 N N . LYS A 1 137 ? 34.911 38.628 0.343 1.00 18.72 ? 137 LYS A N 1 ATOM 1023 C CA . LYS A 1 137 ? 34.814 38.741 -1.114 1.00 19.39 ? 137 LYS A CA 1 ATOM 1024 C C . LYS A 1 137 ? 33.784 39.789 -1.533 1.00 20.14 ? 137 LYS A C 1 ATOM 1025 O O . LYS A 1 137 ? 34.052 40.611 -2.425 1.00 20.11 ? 137 LYS A O 1 ATOM 1026 C CB . LYS A 1 137 ? 34.469 37.393 -1.742 1.00 19.27 ? 137 LYS A CB 1 ATOM 1027 C CG . LYS A 1 137 ? 34.154 37.439 -3.255 1.00 19.33 ? 137 LYS A CG 1 ATOM 1028 C CD . LYS A 1 137 ? 35.243 38.128 -4.094 1.00 18.89 ? 137 LYS A CD 1 ATOM 1029 C CE . LYS A 1 137 ? 36.548 37.362 -4.130 1.00 18.90 ? 137 LYS A CE 1 ATOM 1030 N NZ . LYS A 1 137 ? 37.376 37.759 -5.322 1.00 16.02 ? 137 LYS A NZ 1 ATOM 1031 N N . LYS A 1 138 ? 32.609 39.754 -0.906 1.00 20.91 ? 138 LYS A N 1 ATOM 1032 C CA . LYS A 1 138 ? 31.561 40.743 -1.177 1.00 22.27 ? 138 LYS A CA 1 ATOM 1033 C C . LYS A 1 138 ? 32.054 42.180 -0.948 1.00 21.62 ? 138 LYS A C 1 ATOM 1034 O O . LYS A 1 138 ? 31.651 43.110 -1.652 1.00 22.04 ? 138 LYS A O 1 ATOM 1035 C CB . LYS A 1 138 ? 30.290 40.429 -0.364 1.00 22.47 ? 138 LYS A CB 1 ATOM 1036 C CG . LYS A 1 138 ? 29.522 39.232 -0.943 1.00 23.96 ? 138 LYS A CG 1 ATOM 1037 C CD . LYS A 1 138 ? 28.431 38.686 -0.025 1.00 24.70 ? 138 LYS A CD 1 ATOM 1038 C CE . LYS A 1 138 ? 27.502 37.726 -0.811 1.00 25.98 ? 138 LYS A CE 1 ATOM 1039 N NZ . LYS A 1 138 ? 27.065 36.485 -0.058 1.00 24.90 ? 138 LYS A NZ 1 ATOM 1040 N N . ALA A 1 139 ? 32.973 42.343 -0.009 1.00 21.66 ? 139 ALA A N 1 ATOM 1041 C CA . ALA A 1 139 ? 33.565 43.645 0.285 1.00 21.35 ? 139 ALA A CA 1 ATOM 1042 C C . ALA A 1 139 ? 34.747 44.016 -0.624 1.00 21.03 ? 139 ALA A C 1 ATOM 1043 O O . ALA A 1 139 ? 35.414 45.010 -0.355 1.00 21.62 ? 139 ALA A O 1 ATOM 1044 C CB . ALA A 1 139 ? 33.996 43.691 1.736 1.00 21.27 ? 139 ALA A CB 1 ATOM 1045 N N . GLY A 1 140 ? 35.018 43.219 -1.665 1.00 20.30 ? 140 GLY A N 1 ATOM 1046 C CA . GLY A 1 140 ? 36.083 43.515 -2.631 1.00 19.74 ? 140 GLY A CA 1 ATOM 1047 C C . GLY A 1 140 ? 37.459 42.912 -2.334 1.00 18.79 ? 140 GLY A C 1 ATOM 1048 O O . GLY A 1 140 ? 38.384 43.105 -3.103 1.00 19.19 ? 140 GLY A O 1 ATOM 1049 N N . LYS A 1 141 ? 37.604 42.185 -1.230 1.00 17.82 ? 141 LYS A N 1 ATOM 1050 C CA . LYS A 1 141 ? 38.896 41.577 -0.881 1.00 16.70 ? 141 LYS A CA 1 ATOM 1051 C C . LYS A 1 141 ? 39.140 40.345 -1.755 1.00 15.72 ? 141 LYS A C 1 ATOM 1052 O O . LYS A 1 141 ? 38.212 39.745 -2.263 1.00 14.72 ? 141 LYS A O 1 ATOM 1053 C CB . LYS A 1 141 ? 38.943 41.179 0.604 1.00 16.44 ? 141 LYS A CB 1 ATOM 1054 C CG . LYS A 1 141 ? 38.864 42.352 1.567 1.00 16.78 ? 141 LYS A CG 1 ATOM 1055 C CD . LYS A 1 141 ? 39.166 41.930 2.987 1.00 16.57 ? 141 LYS A CD 1 ATOM 1056 C CE . LYS A 1 141 ? 38.885 43.042 3.992 1.00 15.43 ? 141 LYS A CE 1 ATOM 1057 N NZ . LYS A 1 141 ? 39.620 44.278 3.661 1.00 16.01 ? 141 LYS A NZ 1 ATOM 1058 N N . SER A 1 142 ? 40.399 39.997 -1.958 1.00 16.35 ? 142 SER A N 1 ATOM 1059 C CA . SER A 1 142 ? 40.732 38.708 -2.578 1.00 16.09 ? 142 SER A CA 1 ATOM 1060 C C . SER A 1 142 ? 40.683 37.611 -1.516 1.00 15.90 ? 142 SER A C 1 ATOM 1061 O O . SER A 1 142 ? 40.964 37.853 -0.351 1.00 16.41 ? 142 SER A O 1 ATOM 1062 C CB . SER A 1 142 ? 42.114 38.754 -3.206 1.00 16.55 ? 142 SER A CB 1 ATOM 1063 O OG . SER A 1 142 ? 42.181 39.778 -4.179 1.00 15.46 ? 142 SER A OG 1 ATOM 1064 N N . VAL A 1 143 ? 40.310 36.402 -1.908 1.00 15.69 ? 143 VAL A N 1 ATOM 1065 C CA . VAL A 1 143 ? 40.165 35.333 -0.938 1.00 15.61 ? 143 VAL A CA 1 ATOM 1066 C C . VAL A 1 143 ? 40.864 34.056 -1.380 1.00 15.43 ? 143 VAL A C 1 ATOM 1067 O O . VAL A 1 143 ? 40.879 33.717 -2.559 1.00 14.97 ? 143 VAL A O 1 ATOM 1068 C CB . VAL A 1 143 ? 38.688 35.077 -0.590 1.00 15.59 ? 143 VAL A CB 1 ATOM 1069 C CG1 . VAL A 1 143 ? 38.026 36.381 -0.181 1.00 15.14 ? 143 VAL A CG1 1 ATOM 1070 C CG2 . VAL A 1 143 ? 37.947 34.416 -1.719 1.00 16.04 ? 143 VAL A CG2 1 ATOM 1071 N N . GLY A 1 144 ? 41.452 33.372 -0.405 1.00 14.86 ? 144 GLY A N 1 ATOM 1072 C CA . GLY A 1 144 ? 42.268 32.210 -0.659 1.00 15.23 ? 144 GLY A CA 1 ATOM 1073 C C . GLY A 1 144 ? 41.973 31.076 0.300 1.00 15.38 ? 144 GLY A C 1 ATOM 1074 O O . GLY A 1 144 ? 41.743 31.291 1.498 1.00 15.71 ? 144 GLY A O 1 ATOM 1075 N N . VAL A 1 145 ? 41.969 29.869 -0.248 1.00 15.27 ? 145 VAL A N 1 ATOM 1076 C CA . VAL A 1 145 ? 41.777 28.644 0.508 1.00 15.67 ? 145 VAL A CA 1 ATOM 1077 C C . VAL A 1 145 ? 43.009 27.786 0.255 1.00 15.49 ? 145 VAL A C 1 ATOM 1078 O O . VAL A 1 145 ? 43.336 27.488 -0.889 1.00 15.19 ? 145 VAL A O 1 ATOM 1079 C CB . VAL A 1 145 ? 40.498 27.908 0.047 1.00 15.59 ? 145 VAL A CB 1 ATOM 1080 C CG1 . VAL A 1 145 ? 40.383 26.522 0.678 1.00 16.77 ? 145 VAL A CG1 1 ATOM 1081 C CG2 . VAL A 1 145 ? 39.273 28.738 0.373 1.00 15.51 ? 145 VAL A CG2 1 ATOM 1082 N N . VAL A 1 146 ? 43.703 27.422 1.331 1.00 15.23 ? 146 VAL A N 1 ATOM 1083 C CA . VAL A 1 146 ? 44.935 26.663 1.234 1.00 15.49 ? 146 VAL A CA 1 ATOM 1084 C C . VAL A 1 146 ? 44.873 25.577 2.283 1.00 14.96 ? 146 VAL A C 1 ATOM 1085 O O . VAL A 1 146 ? 44.659 25.874 3.469 1.00 15.50 ? 146 VAL A O 1 ATOM 1086 C CB . VAL A 1 146 ? 46.175 27.537 1.516 1.00 15.60 ? 146 VAL A CB 1 ATOM 1087 C CG1 . VAL A 1 146 ? 47.462 26.708 1.455 1.00 17.09 ? 146 VAL A CG1 1 ATOM 1088 C CG2 . VAL A 1 146 ? 46.247 28.715 0.571 1.00 17.76 ? 146 VAL A CG2 1 ATOM 1089 N N . THR A 1 147 ? 45.091 24.336 1.852 1.00 13.45 ? 147 THR A N 1 ATOM 1090 C CA . THR A 1 147 ? 45.063 23.205 2.758 1.00 13.00 ? 147 THR A CA 1 ATOM 1091 C C . THR A 1 147 ? 45.817 22.008 2.195 1.00 12.95 ? 147 THR A C 1 ATOM 1092 O O . THR A 1 147 ? 45.991 21.866 0.980 1.00 13.08 ? 147 THR A O 1 ATOM 1093 C CB . THR A 1 147 ? 43.600 22.812 3.071 1.00 12.15 ? 147 THR A CB 1 ATOM 1094 O OG1 . THR A 1 147 ? 43.554 21.610 3.857 1.00 12.50 ? 147 THR A OG1 1 ATOM 1095 C CG2 . THR A 1 147 ? 42.828 22.491 1.814 1.00 11.83 ? 147 THR A CG2 1 ATOM 1096 N N . THR A 1 148 ? 46.271 21.153 3.100 1.00 12.72 ? 148 THR A N 1 ATOM 1097 C CA . THR A 1 148 ? 46.890 19.871 2.727 1.00 12.68 ? 148 THR A CA 1 ATOM 1098 C C . THR A 1 148 ? 45.879 18.750 2.493 1.00 12.95 ? 148 THR A C 1 ATOM 1099 O O . THR A 1 148 ? 46.264 17.665 2.050 1.00 13.18 ? 148 THR A O 1 ATOM 1100 C CB . THR A 1 148 ? 47.833 19.425 3.836 1.00 13.03 ? 148 THR A CB 1 ATOM 1101 O OG1 . THR A 1 148 ? 47.156 19.506 5.101 1.00 12.45 ? 148 THR A OG1 1 ATOM 1102 C CG2 . THR A 1 148 ? 49.028 20.356 3.952 1.00 12.53 ? 148 THR A CG2 1 ATOM 1103 N N . THR A 1 149 ? 44.597 18.981 2.803 1.00 12.85 ? 149 THR A N 1 ATOM 1104 C CA . THR A 1 149 ? 43.552 18.044 2.382 1.00 12.66 ? 149 THR A CA 1 ATOM 1105 C C . THR A 1 149 ? 42.978 18.419 1.026 1.00 12.88 ? 149 THR A C 1 ATOM 1106 O O . THR A 1 149 ? 43.352 19.407 0.410 1.00 12.79 ? 149 THR A O 1 ATOM 1107 C CB . THR A 1 149 ? 42.404 17.934 3.409 1.00 12.72 ? 149 THR A CB 1 ATOM 1108 O OG1 . THR A 1 149 ? 41.708 19.191 3.527 1.00 13.00 ? 149 THR A OG1 1 ATOM 1109 C CG2 . THR A 1 149 ? 42.946 17.617 4.792 1.00 12.32 ? 149 THR A CG2 1 ATOM 1110 N N . ARG A 1 150 ? 42.060 17.585 0.572 1.00 13.47 ? 150 ARG A N 1 ATOM 1111 C CA . ARG A 1 150 ? 41.188 17.939 -0.511 1.00 13.29 ? 150 ARG A CA 1 ATOM 1112 C C . ARG A 1 150 ? 40.613 19.311 -0.193 1.00 13.77 ? 150 ARG A C 1 ATOM 1113 O O . ARG A 1 150 ? 40.273 19.609 0.956 1.00 12.54 ? 150 ARG A O 1 ATOM 1114 C CB . ARG A 1 150 ? 40.068 16.913 -0.640 1.00 13.38 ? 150 ARG A CB 1 ATOM 1115 C CG . ARG A 1 150 ? 40.547 15.543 -1.066 1.00 14.55 ? 150 ARG A CG 1 ATOM 1116 C CD . ARG A 1 150 ? 39.635 14.406 -0.617 1.00 15.22 ? 150 ARG A CD 1 ATOM 1117 N NE . ARG A 1 150 ? 39.936 13.973 0.738 1.00 17.09 ? 150 ARG A NE 1 ATOM 1118 C CZ . ARG A 1 150 ? 39.295 13.001 1.371 1.00 18.23 ? 150 ARG A CZ 1 ATOM 1119 N NH1 . ARG A 1 150 ? 39.665 12.663 2.595 1.00 17.98 ? 150 ARG A NH1 1 ATOM 1120 N NH2 . ARG A 1 150 ? 38.265 12.379 0.811 1.00 20.61 ? 150 ARG A NH2 1 ATOM 1121 N N . VAL A 1 151 ? 40.565 20.161 -1.205 1.00 13.74 ? 151 VAL A N 1 ATOM 1122 C CA . VAL A 1 151 ? 39.954 21.476 -1.071 1.00 14.57 ? 151 VAL A CA 1 ATOM 1123 C C . VAL A 1 151 ? 38.427 21.387 -0.842 1.00 14.48 ? 151 VAL A C 1 ATOM 1124 O O . VAL A 1 151 ? 37.800 22.375 -0.486 1.00 15.17 ? 151 VAL A O 1 ATOM 1125 C CB . VAL A 1 151 ? 40.287 22.370 -2.290 1.00 14.24 ? 151 VAL A CB 1 ATOM 1126 C CG1 . VAL A 1 151 ? 41.803 22.584 -2.393 1.00 15.59 ? 151 VAL A CG1 1 ATOM 1127 C CG2 . VAL A 1 151 ? 39.708 21.793 -3.578 1.00 16.09 ? 151 VAL A CG2 1 ATOM 1128 N N . GLN A 1 152 ? 37.855 20.198 -1.046 1.00 14.24 ? 152 GLN A N 1 ATOM 1129 C CA . GLN A 1 152 ? 36.428 19.932 -0.834 1.00 14.29 ? 152 GLN A CA 1 ATOM 1130 C C . GLN A 1 152 ? 36.202 19.250 0.524 1.00 14.00 ? 152 GLN A C 1 ATOM 1131 O O . GLN A 1 152 ? 35.079 18.856 0.848 1.00 15.29 ? 152 GLN A O 1 ATOM 1132 C CB . GLN A 1 152 ? 35.872 19.051 -1.961 1.00 14.04 ? 152 GLN A CB 1 ATOM 1133 C CG . GLN A 1 152 ? 36.212 19.525 -3.362 1.00 14.38 ? 152 GLN A CG 1 ATOM 1134 C CD . GLN A 1 152 ? 37.533 18.976 -3.903 1.00 15.68 ? 152 GLN A CD 1 ATOM 1135 O OE1 . GLN A 1 152 ? 38.324 18.398 -3.156 1.00 16.35 ? 152 GLN A OE1 1 ATOM 1136 N NE2 . GLN A 1 152 ? 37.757 19.146 -5.206 1.00 14.44 ? 152 GLN A NE2 1 ATOM 1137 N N . HIS A 1 153 ? 37.271 19.129 1.315 1.00 13.88 ? 153 HIS A N 1 ATOM 1138 C CA . HIS A 1 153 ? 37.191 18.561 2.655 1.00 13.83 ? 153 HIS A CA 1 ATOM 1139 C C . HIS A 1 153 ? 36.468 19.528 3.599 1.00 13.61 ? 153 HIS A C 1 ATOM 1140 O O . HIS A 1 153 ? 36.256 20.688 3.251 1.00 14.20 ? 153 HIS A O 1 ATOM 1141 C CB . HIS A 1 153 ? 38.582 18.184 3.174 1.00 13.87 ? 153 HIS A CB 1 ATOM 1142 C CG . HIS A 1 153 ? 38.571 17.002 4.080 1.00 14.21 ? 153 HIS A CG 1 ATOM 1143 N ND1 . HIS A 1 153 ? 38.520 15.709 3.608 1.00 15.89 ? 153 HIS A ND1 1 ATOM 1144 C CD2 . HIS A 1 153 ? 38.581 16.913 5.429 1.00 13.87 ? 153 HIS A CD2 1 ATOM 1145 C CE1 . HIS A 1 153 ? 38.505 14.873 4.632 1.00 15.28 ? 153 HIS A CE1 1 ATOM 1146 N NE2 . HIS A 1 153 ? 38.543 15.577 5.748 1.00 15.73 ? 153 HIS A NE2 1 ATOM 1147 N N . ALA A 1 154 ? 36.086 19.050 4.780 1.00 13.22 ? 154 ALA A N 1 ATOM 1148 C CA . ALA A 1 154 ? 35.099 19.748 5.603 1.00 13.07 ? 154 ALA A CA 1 ATOM 1149 C C . ALA A 1 154 ? 35.560 21.155 5.970 1.00 13.20 ? 154 ALA A C 1 ATOM 1150 O O . ALA A 1 154 ? 34.783 22.112 5.913 1.00 12.56 ? 154 ALA A O 1 ATOM 1151 C CB . ALA A 1 154 ? 34.794 18.945 6.847 1.00 13.27 ? 154 ALA A CB 1 ATOM 1152 N N . SER A 1 155 ? 36.833 21.284 6.329 1.00 13.32 ? 155 SER A N 1 ATOM 1153 C CA . SER A 1 155 ? 37.358 22.561 6.805 1.00 13.42 ? 155 SER A CA 1 ATOM 1154 C C . SER A 1 155 ? 37.379 23.660 5.723 1.00 13.55 ? 155 SER A C 1 ATOM 1155 O O . SER A 1 155 ? 36.732 24.682 5.908 1.00 14.36 ? 155 SER A O 1 ATOM 1156 C CB . SER A 1 155 ? 38.728 22.385 7.486 1.00 13.22 ? 155 SER A CB 1 ATOM 1157 O OG . SER A 1 155 ? 38.744 21.249 8.347 1.00 12.19 ? 155 SER A OG 1 ATOM 1158 N N . PRO A 1 156 ? 38.089 23.480 4.605 1.00 14.34 ? 156 PRO A N 1 ATOM 1159 C CA . PRO A 1 156 ? 38.058 24.487 3.546 1.00 14.45 ? 156 PRO A CA 1 ATOM 1160 C C . PRO A 1 156 ? 36.645 24.707 3.000 1.00 14.51 ? 156 PRO A C 1 ATOM 1161 O O . PRO A 1 156 ? 36.278 25.836 2.656 1.00 14.25 ? 156 PRO A O 1 ATOM 1162 C CB . PRO A 1 156 ? 38.993 23.901 2.485 1.00 14.83 ? 156 PRO A CB 1 ATOM 1163 C CG . PRO A 1 156 ? 38.967 22.482 2.722 1.00 14.43 ? 156 PRO A CG 1 ATOM 1164 C CD . PRO A 1 156 ? 38.948 22.354 4.222 1.00 14.04 ? 156 PRO A CD 1 ATOM 1165 N N . ALA A 1 157 ? 35.852 23.638 2.965 1.00 14.96 ? 157 ALA A N 1 ATOM 1166 C CA . ALA A 1 157 ? 34.473 23.709 2.490 1.00 14.84 ? 157 ALA A CA 1 ATOM 1167 C C . ALA A 1 157 ? 33.652 24.679 3.328 1.00 14.47 ? 157 ALA A C 1 ATOM 1168 O O . ALA A 1 157 ? 32.759 25.340 2.816 1.00 15.62 ? 157 ALA A O 1 ATOM 1169 C CB . ALA A 1 157 ? 33.828 22.324 2.482 1.00 14.52 ? 157 ALA A CB 1 ATOM 1170 N N . GLY A 1 158 ? 33.964 24.782 4.611 1.00 14.37 ? 158 GLY A N 1 ATOM 1171 C CA . GLY A 1 158 ? 33.311 25.752 5.478 1.00 13.98 ? 158 GLY A CA 1 ATOM 1172 C C . GLY A 1 158 ? 33.445 27.175 5.007 1.00 14.07 ? 158 GLY A C 1 ATOM 1173 O O . GLY A 1 158 ? 32.610 28.008 5.358 1.00 13.99 ? 158 GLY A O 1 ATOM 1174 N N . THR A 1 159 ? 34.483 27.477 4.222 1.00 14.02 ? 159 THR A N 1 ATOM 1175 C CA . THR A 1 159 ? 34.650 28.827 3.711 1.00 14.86 ? 159 THR A CA 1 ATOM 1176 C C . THR A 1 159 ? 33.675 29.181 2.595 1.00 14.90 ? 159 THR A C 1 ATOM 1177 O O . THR A 1 159 ? 33.464 30.355 2.354 1.00 14.68 ? 159 THR A O 1 ATOM 1178 C CB . THR A 1 159 ? 36.072 29.110 3.193 1.00 15.13 ? 159 THR A CB 1 ATOM 1179 O OG1 . THR A 1 159 ? 36.387 28.251 2.082 1.00 14.88 ? 159 THR A OG1 1 ATOM 1180 C CG2 . THR A 1 159 ? 37.122 28.851 4.234 1.00 15.93 ? 159 THR A CG2 1 ATOM 1181 N N . TYR A 1 160 ? 33.116 28.183 1.899 1.00 15.07 ? 160 TYR A N 1 ATOM 1182 C CA . TYR A 1 160 ? 32.323 28.465 0.687 1.00 15.05 ? 160 TYR A CA 1 ATOM 1183 C C . TYR A 1 160 ? 31.040 27.651 0.510 1.00 15.13 ? 160 TYR A C 1 ATOM 1184 O O . TYR A 1 160 ? 30.105 28.100 -0.173 1.00 16.03 ? 160 TYR A O 1 ATOM 1185 C CB . TYR A 1 160 ? 33.196 28.320 -0.563 1.00 15.00 ? 160 TYR A CB 1 ATOM 1186 C CG . TYR A 1 160 ? 33.779 26.942 -0.757 1.00 14.69 ? 160 TYR A CG 1 ATOM 1187 C CD1 . TYR A 1 160 ? 35.093 26.666 -0.386 1.00 15.62 ? 160 TYR A CD1 1 ATOM 1188 C CD2 . TYR A 1 160 ? 33.027 25.919 -1.324 1.00 14.64 ? 160 TYR A CD2 1 ATOM 1189 C CE1 . TYR A 1 160 ? 35.640 25.402 -0.549 1.00 15.41 ? 160 TYR A CE1 1 ATOM 1190 C CE2 . TYR A 1 160 ? 33.567 24.664 -1.520 1.00 15.05 ? 160 TYR A CE2 1 ATOM 1191 C CZ . TYR A 1 160 ? 34.871 24.405 -1.117 1.00 15.14 ? 160 TYR A CZ 1 ATOM 1192 O OH . TYR A 1 160 ? 35.406 23.159 -1.293 1.00 15.69 ? 160 TYR A OH 1 ATOM 1193 N N . ALA A 1 161 ? 30.981 26.469 1.112 1.00 14.66 ? 161 ALA A N 1 ATOM 1194 C CA . ALA A 1 161 ? 29.873 25.552 0.879 1.00 14.30 ? 161 ALA A CA 1 ATOM 1195 C C . ALA A 1 161 ? 28.804 25.613 1.963 1.00 14.29 ? 161 ALA A C 1 ATOM 1196 O O . ALA A 1 161 ? 28.997 26.163 3.056 1.00 14.31 ? 161 ALA A O 1 ATOM 1197 C CB . ALA A 1 161 ? 30.400 24.116 0.776 1.00 13.90 ? 161 ALA A CB 1 ATOM 1198 N N . HIS A 1 162 ? 27.682 25.000 1.625 1.00 14.22 ? 162 HIS A N 1 ATOM 1199 C CA . HIS A 1 162 ? 26.575 24.777 2.510 1.00 14.17 ? 162 HIS A CA 1 ATOM 1200 C C . HIS A 1 162 ? 26.041 23.403 2.123 1.00 14.32 ? 162 HIS A C 1 ATOM 1201 O O . HIS A 1 162 ? 25.511 23.207 1.018 1.00 14.36 ? 162 HIS A O 1 ATOM 1202 C CB . HIS A 1 162 ? 25.501 25.861 2.326 1.00 13.92 ? 162 HIS A CB 1 ATOM 1203 C CG . HIS A 1 162 ? 26.034 27.256 2.401 1.00 14.63 ? 162 HIS A CG 1 ATOM 1204 N ND1 . HIS A 1 162 ? 26.209 28.047 1.284 1.00 16.32 ? 162 HIS A ND1 1 ATOM 1205 C CD2 . HIS A 1 162 ? 26.440 27.998 3.456 1.00 14.53 ? 162 HIS A CD2 1 ATOM 1206 C CE1 . HIS A 1 162 ? 26.694 29.220 1.655 1.00 14.63 ? 162 HIS A CE1 1 ATOM 1207 N NE2 . HIS A 1 162 ? 26.841 29.216 2.966 1.00 16.01 ? 162 HIS A NE2 1 ATOM 1208 N N . THR A 1 163 ? 26.198 22.438 3.007 1.00 14.38 ? 163 THR A N 1 ATOM 1209 C CA . THR A 1 163 ? 25.708 21.112 2.709 1.00 14.60 ? 163 THR A CA 1 ATOM 1210 C C . THR A 1 163 ? 25.353 20.364 3.983 1.00 14.54 ? 163 THR A C 1 ATOM 1211 O O . THR A 1 163 ? 25.998 20.523 5.022 1.00 14.82 ? 163 THR A O 1 ATOM 1212 C CB . THR A 1 163 ? 26.747 20.331 1.859 1.00 14.82 ? 163 THR A CB 1 ATOM 1213 O OG1 . THR A 1 163 ? 26.274 19.002 1.595 1.00 15.51 ? 163 THR A OG1 1 ATOM 1214 C CG2 . THR A 1 163 ? 28.072 20.147 2.616 1.00 15.43 ? 163 THR A CG2 1 ATOM 1215 N N . VAL A 1 164 ? 24.292 19.574 3.886 1.00 14.54 ? 164 VAL A N 1 ATOM 1216 C CA . VAL A 1 164 ? 23.881 18.696 4.967 1.00 14.18 ? 164 VAL A CA 1 ATOM 1217 C C . VAL A 1 164 ? 24.782 17.473 5.073 1.00 14.68 ? 164 VAL A C 1 ATOM 1218 O O . VAL A 1 164 ? 24.631 16.692 5.989 1.00 14.56 ? 164 VAL A O 1 ATOM 1219 C CB . VAL A 1 164 ? 22.415 18.238 4.796 1.00 14.24 ? 164 VAL A CB 1 ATOM 1220 C CG1 . VAL A 1 164 ? 21.467 19.414 5.003 1.00 14.58 ? 164 VAL A CG1 1 ATOM 1221 C CG2 . VAL A 1 164 ? 22.173 17.572 3.435 1.00 14.59 ? 164 VAL A CG2 1 ATOM 1222 N N . ASN A 1 165 ? 25.686 17.273 4.126 1.00 14.99 ? 165 ASN A N 1 ATOM 1223 C CA . ASN A 1 165 ? 26.527 16.096 4.181 1.00 15.56 ? 165 ASN A CA 1 ATOM 1224 C C . ASN A 1 165 ? 27.918 16.362 3.645 1.00 15.59 ? 165 ASN A C 1 ATOM 1225 O O . ASN A 1 165 ? 28.127 16.480 2.429 1.00 14.97 ? 165 ASN A O 1 ATOM 1226 C CB . ASN A 1 165 ? 25.875 14.935 3.438 1.00 15.54 ? 165 ASN A CB 1 ATOM 1227 C CG . ASN A 1 165 ? 26.541 13.599 3.739 1.00 16.33 ? 165 ASN A CG 1 ATOM 1228 O OD1 . ASN A 1 165 ? 27.738 13.536 4.068 1.00 16.61 ? 165 ASN A OD1 1 ATOM 1229 N ND2 . ASN A 1 165 ? 25.764 12.523 3.639 1.00 17.58 ? 165 ASN A ND2 1 ATOM 1230 N N . ARG A 1 166 ? 28.867 16.409 4.575 1.00 15.78 ? 166 ARG A N 1 ATOM 1231 C CA . ARG A 1 166 ? 30.280 16.593 4.265 1.00 16.68 ? 166 ARG A CA 1 ATOM 1232 C C . ARG A 1 166 ? 30.886 15.558 3.302 1.00 16.47 ? 166 ARG A C 1 ATOM 1233 O O . ARG A 1 166 ? 31.925 15.802 2.678 1.00 16.46 ? 166 ARG A O 1 ATOM 1234 C CB . ARG A 1 166 ? 31.097 16.584 5.567 1.00 16.89 ? 166 ARG A CB 1 ATOM 1235 C CG . ARG A 1 166 ? 31.091 15.237 6.286 1.00 17.07 ? 166 ARG A CG 1 ATOM 1236 C CD . ARG A 1 166 ? 32.043 15.179 7.478 1.00 17.45 ? 166 ARG A CD 1 ATOM 1237 N NE . ARG A 1 166 ? 33.434 15.082 7.063 1.00 16.96 ? 166 ARG A NE 1 ATOM 1238 C CZ . ARG A 1 166 ? 34.475 15.206 7.886 1.00 18.38 ? 166 ARG A CZ 1 ATOM 1239 N NH1 . ARG A 1 166 ? 35.702 15.104 7.408 1.00 18.78 ? 166 ARG A NH1 1 ATOM 1240 N NH2 . ARG A 1 166 ? 34.295 15.477 9.177 1.00 17.03 ? 166 ARG A NH2 1 ATOM 1241 N N . ASN A 1 167 ? 30.258 14.392 3.205 1.00 16.63 ? 167 ASN A N 1 ATOM 1242 C CA . ASN A 1 167 ? 30.764 13.330 2.336 1.00 16.63 ? 167 ASN A CA 1 ATOM 1243 C C . ASN A 1 167 ? 30.434 13.526 0.863 1.00 16.08 ? 167 ASN A C 1 ATOM 1244 O O . ASN A 1 167 ? 30.935 12.802 0.005 1.00 16.65 ? 167 ASN A O 1 ATOM 1245 C CB . ASN A 1 167 ? 30.253 11.987 2.828 1.00 16.77 ? 167 ASN A CB 1 ATOM 1246 C CG . ASN A 1 167 ? 30.608 11.751 4.278 1.00 18.55 ? 167 ASN A CG 1 ATOM 1247 O OD1 . ASN A 1 167 ? 31.777 11.733 4.628 1.00 19.73 ? 167 ASN A OD1 1 ATOM 1248 N ND2 . ASN A 1 167 ? 29.606 11.594 5.124 1.00 20.76 ? 167 ASN A ND2 1 ATOM 1249 N N . TRP A 1 168 ? 29.639 14.540 0.555 1.00 16.49 ? 168 TRP A N 1 ATOM 1250 C CA . TRP A 1 168 ? 29.240 14.810 -0.831 1.00 16.03 ? 168 TRP A CA 1 ATOM 1251 C C . TRP A 1 168 ? 30.295 15.553 -1.640 1.00 16.21 ? 168 TRP A C 1 ATOM 1252 O O . TRP A 1 168 ? 30.074 16.675 -2.081 1.00 16.06 ? 168 TRP A O 1 ATOM 1253 C CB . TRP A 1 168 ? 27.901 15.537 -0.843 1.00 15.91 ? 168 TRP A CB 1 ATOM 1254 C CG . TRP A 1 168 ? 26.779 14.684 -0.327 1.00 16.12 ? 168 TRP A CG 1 ATOM 1255 C CD1 . TRP A 1 168 ? 26.807 13.338 -0.081 1.00 15.95 ? 168 TRP A CD1 1 ATOM 1256 C CD2 . TRP A 1 168 ? 25.430 15.104 -0.070 1.00 15.92 ? 168 TRP A CD2 1 ATOM 1257 N NE1 . TRP A 1 168 ? 25.577 12.910 0.362 1.00 16.14 ? 168 TRP A NE1 1 ATOM 1258 C CE2 . TRP A 1 168 ? 24.711 13.971 0.365 1.00 16.08 ? 168 TRP A CE2 1 ATOM 1259 C CE3 . TRP A 1 168 ? 24.765 16.332 -0.127 1.00 16.26 ? 168 TRP A CE3 1 ATOM 1260 C CZ2 . TRP A 1 168 ? 23.373 14.033 0.738 1.00 16.28 ? 168 TRP A CZ2 1 ATOM 1261 C CZ3 . TRP A 1 168 ? 23.418 16.389 0.232 1.00 15.71 ? 168 TRP A CZ3 1 ATOM 1262 C CH2 . TRP A 1 168 ? 22.743 15.247 0.652 1.00 15.99 ? 168 TRP A CH2 1 ATOM 1263 N N . TYR A 1 169 ? 31.441 14.909 -1.860 1.00 16.50 ? 169 TYR A N 1 ATOM 1264 C CA . TYR A 1 169 ? 32.573 15.549 -2.521 1.00 16.52 ? 169 TYR A CA 1 ATOM 1265 C C . TYR A 1 169 ? 32.303 15.875 -4.003 1.00 16.58 ? 169 TYR A C 1 ATOM 1266 O O . TYR A 1 169 ? 32.607 16.975 -4.478 1.00 15.89 ? 169 TYR A O 1 ATOM 1267 C CB . TYR A 1 169 ? 33.828 14.655 -2.410 1.00 16.55 ? 169 TYR A CB 1 ATOM 1268 C CG . TYR A 1 169 ? 34.312 14.444 -0.985 1.00 15.99 ? 169 TYR A CG 1 ATOM 1269 C CD1 . TYR A 1 169 ? 34.773 15.514 -0.221 1.00 14.99 ? 169 TYR A CD1 1 ATOM 1270 C CD2 . TYR A 1 169 ? 34.289 13.178 -0.401 1.00 16.38 ? 169 TYR A CD2 1 ATOM 1271 C CE1 . TYR A 1 169 ? 35.193 15.332 1.075 1.00 16.51 ? 169 TYR A CE1 1 ATOM 1272 C CE2 . TYR A 1 169 ? 34.728 12.976 0.902 1.00 16.59 ? 169 TYR A CE2 1 ATOM 1273 C CZ . TYR A 1 169 ? 35.173 14.057 1.633 1.00 16.17 ? 169 TYR A CZ 1 ATOM 1274 O OH . TYR A 1 169 ? 35.589 13.865 2.910 1.00 17.06 ? 169 TYR A OH 1 ATOM 1275 N N . SER A 1 170 ? 31.777 14.895 -4.732 1.00 17.25 ? 170 SER A N 1 ATOM 1276 C CA . SER A 1 170 ? 31.387 15.081 -6.123 1.00 17.20 ? 170 SER A CA 1 ATOM 1277 C C . SER A 1 170 ? 29.972 14.573 -6.260 1.00 17.82 ? 170 SER A C 1 ATOM 1278 O O . SER A 1 170 ? 29.408 14.032 -5.315 1.00 17.95 ? 170 SER A O 1 ATOM 1279 C CB . SER A 1 170 ? 32.307 14.333 -7.093 1.00 17.51 ? 170 SER A CB 1 ATOM 1280 O OG . SER A 1 170 ? 32.012 12.945 -7.126 1.00 16.40 ? 170 SER A OG 1 ATOM 1281 N N . ASP A 1 171 ? 29.400 14.769 -7.439 1.00 18.31 ? 171 ASP A N 1 ATOM 1282 C CA . ASP A 1 171 ? 28.043 14.308 -7.730 1.00 19.39 ? 171 ASP A CA 1 ATOM 1283 C C . ASP A 1 171 ? 27.890 12.807 -7.513 1.00 19.47 ? 171 ASP A C 1 ATOM 1284 O O . ASP A 1 171 ? 26.806 12.323 -7.191 1.00 18.92 ? 171 ASP A O 1 ATOM 1285 C CB . ASP A 1 171 ? 27.683 14.673 -9.169 1.00 19.40 ? 171 ASP A CB 1 ATOM 1286 C CG . ASP A 1 171 ? 28.620 14.048 -10.172 1.00 21.16 ? 171 ASP A CG 1 ATOM 1287 O OD1 . ASP A 1 171 ? 29.852 14.160 -9.996 1.00 22.31 ? 171 ASP A OD1 1 ATOM 1288 O OD2 . ASP A 1 171 ? 28.226 13.423 -11.166 1.00 23.66 ? 171 ASP A OD2 1 ATOM 1289 N N . ALA A 1 172 ? 28.986 12.078 -7.696 1.00 20.06 ? 172 ALA A N 1 ATOM 1290 C CA . ALA A 1 172 ? 29.016 10.635 -7.477 1.00 19.90 ? 172 ALA A CA 1 ATOM 1291 C C . ALA A 1 172 ? 28.596 10.246 -6.075 1.00 19.95 ? 172 ALA A C 1 ATOM 1292 O O . ALA A 1 172 ? 28.112 9.141 -5.859 1.00 20.42 ? 172 ALA A O 1 ATOM 1293 C CB . ALA A 1 172 ? 30.403 10.092 -7.767 1.00 20.36 ? 172 ALA A CB 1 ATOM 1294 N N . ASP A 1 173 ? 28.778 11.154 -5.122 1.00 19.46 ? 173 ASP A N 1 ATOM 1295 C CA . ASP A 1 173 ? 28.485 10.882 -3.734 1.00 19.29 ? 173 ASP A CA 1 ATOM 1296 C C . ASP A 1 173 ? 27.076 11.255 -3.317 1.00 18.86 ? 173 ASP A C 1 ATOM 1297 O O . ASP A 1 173 ? 26.630 10.850 -2.250 1.00 19.24 ? 173 ASP A O 1 ATOM 1298 C CB . ASP A 1 173 ? 29.457 11.659 -2.854 1.00 19.00 ? 173 ASP A CB 1 ATOM 1299 C CG . ASP A 1 173 ? 30.891 11.289 -3.125 1.00 19.60 ? 173 ASP A CG 1 ATOM 1300 O OD1 . ASP A 1 173 ? 31.695 12.202 -3.440 1.00 15.92 ? 173 ASP A OD1 1 ATOM 1301 O OD2 . ASP A 1 173 ? 31.275 10.096 -3.070 1.00 18.99 ? 173 ASP A OD2 1 ATOM 1302 N N . VAL A 1 174 ? 26.392 12.050 -4.127 1.00 18.52 ? 174 VAL A N 1 ATOM 1303 C CA . VAL A 1 174 ? 25.082 12.576 -3.740 1.00 19.08 ? 174 VAL A CA 1 ATOM 1304 C C . VAL A 1 174 ? 23.991 11.589 -4.183 1.00 19.30 ? 174 VAL A C 1 ATOM 1305 O O . VAL A 1 174 ? 23.968 11.207 -5.340 1.00 19.01 ? 174 VAL A O 1 ATOM 1306 C CB . VAL A 1 174 ? 24.849 13.956 -4.390 1.00 18.91 ? 174 VAL A CB 1 ATOM 1307 C CG1 . VAL A 1 174 ? 23.536 14.564 -3.938 1.00 19.51 ? 174 VAL A CG1 1 ATOM 1308 C CG2 . VAL A 1 174 ? 26.012 14.884 -4.061 1.00 18.22 ? 174 VAL A CG2 1 ATOM 1309 N N . PRO A 1 175 ? 23.107 11.164 -3.284 1.00 20.09 ? 175 PRO A N 1 ATOM 1310 C CA . PRO A 1 175 ? 21.987 10.327 -3.677 1.00 20.32 ? 175 PRO A CA 1 ATOM 1311 C C . PRO A 1 175 ? 21.128 11.036 -4.712 1.00 20.56 ? 175 PRO A C 1 ATOM 1312 O O . PRO A 1 175 ? 21.046 12.260 -4.697 1.00 19.39 ? 175 PRO A O 1 ATOM 1313 C CB . PRO A 1 175 ? 21.196 10.152 -2.383 1.00 20.46 ? 175 PRO A CB 1 ATOM 1314 C CG . PRO A 1 175 ? 22.116 10.464 -1.309 1.00 21.66 ? 175 PRO A CG 1 ATOM 1315 C CD . PRO A 1 175 ? 23.114 11.421 -1.839 1.00 20.35 ? 175 PRO A CD 1 ATOM 1316 N N . ALA A 1 176 ? 20.497 10.262 -5.593 1.00 20.80 ? 176 ALA A N 1 ATOM 1317 C CA . ALA A 1 176 ? 19.610 10.803 -6.635 1.00 21.13 ? 176 ALA A CA 1 ATOM 1318 C C . ALA A 1 176 ? 18.559 11.744 -6.069 1.00 21.14 ? 176 ALA A C 1 ATOM 1319 O O . ALA A 1 176 ? 18.295 12.788 -6.640 1.00 21.63 ? 176 ALA A O 1 ATOM 1320 C CB . ALA A 1 176 ? 18.924 9.656 -7.392 1.00 21.39 ? 176 ALA A CB 1 ATOM 1321 N N . SER A 1 177 ? 17.977 11.390 -4.935 1.00 21.46 ? 177 SER A N 1 ATOM 1322 C CA . SER A 1 177 ? 16.918 12.209 -4.361 1.00 21.71 ? 177 SER A CA 1 ATOM 1323 C C . SER A 1 177 ? 17.439 13.602 -3.998 1.00 21.12 ? 177 SER A C 1 ATOM 1324 O O . SER A 1 177 ? 16.760 14.598 -4.223 1.00 20.85 ? 177 SER A O 1 ATOM 1325 C CB . SER A 1 177 ? 16.313 11.533 -3.136 1.00 21.96 ? 177 SER A CB 1 ATOM 1326 O OG . SER A 1 177 ? 17.303 11.358 -2.133 1.00 24.79 ? 177 SER A OG 1 ATOM 1327 N N . ALA A 1 178 ? 18.649 13.662 -3.446 1.00 20.27 ? 178 ALA A N 1 ATOM 1328 C CA . ALA A 1 178 ? 19.268 14.938 -3.094 1.00 20.24 ? 178 ALA A CA 1 ATOM 1329 C C . ALA A 1 178 ? 19.703 15.720 -4.326 1.00 20.34 ? 178 ALA A C 1 ATOM 1330 O O . ALA A 1 178 ? 19.623 16.950 -4.346 1.00 19.23 ? 178 ALA A O 1 ATOM 1331 C CB . ALA A 1 178 ? 20.454 14.707 -2.150 1.00 20.24 ? 178 ALA A CB 1 ATOM 1332 N N . ARG A 1 179 ? 20.197 15.015 -5.342 1.00 21.04 ? 179 ARG A N 1 ATOM 1333 C CA . ARG A 1 179 ? 20.539 15.657 -6.607 1.00 22.31 ? 179 ARG A CA 1 ATOM 1334 C C . ARG A 1 179 ? 19.286 16.254 -7.234 1.00 22.20 ? 179 ARG A C 1 ATOM 1335 O O . ARG A 1 179 ? 19.293 17.386 -7.703 1.00 21.61 ? 179 ARG A O 1 ATOM 1336 C CB . ARG A 1 179 ? 21.189 14.672 -7.582 1.00 22.08 ? 179 ARG A CB 1 ATOM 1337 C CG . ARG A 1 179 ? 22.576 14.211 -7.128 1.00 23.82 ? 179 ARG A CG 1 ATOM 1338 C CD . ARG A 1 179 ? 23.478 13.701 -8.241 1.00 25.84 ? 179 ARG A CD 1 ATOM 1339 N NE . ARG A 1 179 ? 22.776 12.779 -9.133 1.00 30.78 ? 179 ARG A NE 1 ATOM 1340 C CZ . ARG A 1 179 ? 22.415 11.531 -8.811 1.00 32.37 ? 179 ARG A CZ 1 ATOM 1341 N NH1 . ARG A 1 179 ? 22.705 11.018 -7.627 1.00 34.21 ? 179 ARG A NH1 1 ATOM 1342 N NH2 . ARG A 1 179 ? 21.765 10.783 -9.693 1.00 32.61 ? 179 ARG A NH2 1 ATOM 1343 N N . GLN A 1 180 ? 18.209 15.483 -7.211 1.00 22.82 ? 180 GLN A N 1 ATOM 1344 C CA . GLN A 1 180 ? 16.934 15.957 -7.720 1.00 23.69 ? 180 GLN A CA 1 ATOM 1345 C C . GLN A 1 180 ? 16.452 17.185 -6.942 1.00 22.96 ? 180 GLN A C 1 ATOM 1346 O O . GLN A 1 180 ? 15.939 18.138 -7.524 1.00 23.00 ? 180 GLN A O 1 ATOM 1347 C CB . GLN A 1 180 ? 15.909 14.824 -7.693 1.00 24.33 ? 180 GLN A CB 1 ATOM 1348 C CG . GLN A 1 180 ? 15.907 13.972 -8.968 1.00 28.59 ? 180 GLN A CG 1 ATOM 1349 C CD . GLN A 1 180 ? 17.113 13.033 -9.134 1.00 33.65 ? 180 GLN A CD 1 ATOM 1350 O OE1 . GLN A 1 180 ? 18.275 13.477 -9.217 1.00 36.67 ? 180 GLN A OE1 1 ATOM 1351 N NE2 . GLN A 1 180 ? 16.829 11.727 -9.221 1.00 36.89 ? 180 GLN A NE2 1 ATOM 1352 N N . GLU A 1 181 ? 16.671 17.179 -5.633 1.00 22.49 ? 181 GLU A N 1 ATOM 1353 C CA . GLU A 1 181 ? 16.292 18.293 -4.775 1.00 22.15 ? 181 GLU A CA 1 ATOM 1354 C C . GLU A 1 181 ? 17.254 19.464 -4.812 1.00 21.85 ? 181 GLU A C 1 ATOM 1355 O O . GLU A 1 181 ? 17.061 20.428 -4.086 1.00 22.01 ? 181 GLU A O 1 ATOM 1356 C CB . GLU A 1 181 ? 16.144 17.815 -3.339 1.00 22.46 ? 181 GLU A CB 1 ATOM 1357 C CG . GLU A 1 181 ? 14.921 16.945 -3.149 1.00 23.20 ? 181 GLU A CG 1 ATOM 1358 C CD . GLU A 1 181 ? 14.893 16.240 -1.817 1.00 25.30 ? 181 GLU A CD 1 ATOM 1359 O OE1 . GLU A 1 181 ? 13.856 15.616 -1.513 1.00 27.67 ? 181 GLU A OE1 1 ATOM 1360 O OE2 . GLU A 1 181 ? 15.896 16.305 -1.075 1.00 26.68 ? 181 GLU A OE2 1 ATOM 1361 N N . GLY A 1 182 ? 18.294 19.380 -5.630 1.00 21.25 ? 182 GLY A N 1 ATOM 1362 C CA . GLY A 1 182 ? 19.171 20.514 -5.893 1.00 21.00 ? 182 GLY A CA 1 ATOM 1363 C C . GLY A 1 182 ? 20.297 20.750 -4.898 1.00 20.93 ? 182 GLY A C 1 ATOM 1364 O O . GLY A 1 182 ? 20.888 21.832 -4.888 1.00 21.32 ? 182 GLY A O 1 ATOM 1365 N N . CYS A 1 183 ? 20.596 19.761 -4.055 1.00 20.14 ? 183 CYS A N 1 ATOM 1366 C CA . CYS A 1 183 ? 21.779 19.834 -3.206 1.00 20.35 ? 183 CYS A CA 1 ATOM 1367 C C . CYS A 1 183 ? 23.028 19.537 -4.039 1.00 20.40 ? 183 CYS A C 1 ATOM 1368 O O . CYS A 1 183 ? 23.201 18.415 -4.533 1.00 21.31 ? 183 CYS A O 1 ATOM 1369 C CB . CYS A 1 183 ? 21.700 18.844 -2.047 1.00 20.13 ? 183 CYS A CB 1 ATOM 1370 S SG . CYS A 1 183 ? 20.583 19.339 -0.736 1.00 20.61 ? 183 CYS A SG 1 ATOM 1371 N N . GLN A 1 184 ? 23.885 20.541 -4.199 1.00 19.67 ? 184 GLN A N 1 ATOM 1372 C CA . GLN A 1 184 ? 25.067 20.420 -5.043 1.00 19.68 ? 184 GLN A CA 1 ATOM 1373 C C . GLN A 1 184 ? 26.233 19.798 -4.284 1.00 18.54 ? 184 GLN A C 1 ATOM 1374 O O . GLN A 1 184 ? 26.456 20.113 -3.112 1.00 17.09 ? 184 GLN A O 1 ATOM 1375 C CB . GLN A 1 184 ? 25.493 21.797 -5.537 1.00 20.04 ? 184 GLN A CB 1 ATOM 1376 C CG . GLN A 1 184 ? 24.487 22.462 -6.454 1.00 21.36 ? 184 GLN A CG 1 ATOM 1377 C CD . GLN A 1 184 ? 25.055 23.731 -7.079 1.00 22.74 ? 184 GLN A CD 1 ATOM 1378 O OE1 . GLN A 1 184 ? 25.126 23.845 -8.306 1.00 29.25 ? 184 GLN A OE1 1 ATOM 1379 N NE2 . GLN A 1 184 ? 25.479 24.671 -6.241 1.00 26.86 ? 184 GLN A NE2 1 ATOM 1380 N N . ASP A 1 185 ? 26.978 18.923 -4.958 1.00 17.73 ? 185 ASP A N 1 ATOM 1381 C CA . ASP A 1 185 ? 28.209 18.385 -4.383 1.00 17.14 ? 185 ASP A CA 1 ATOM 1382 C C . ASP A 1 185 ? 29.180 19.512 -4.118 1.00 16.32 ? 185 ASP A C 1 ATOM 1383 O O . ASP A 1 185 ? 29.128 20.563 -4.748 1.00 16.00 ? 185 ASP A O 1 ATOM 1384 C CB . ASP A 1 185 ? 28.861 17.377 -5.306 1.00 16.84 ? 185 ASP A CB 1 ATOM 1385 C CG . ASP A 1 185 ? 29.184 17.959 -6.644 1.00 16.52 ? 185 ASP A CG 1 ATOM 1386 O OD1 . ASP A 1 185 ? 30.349 18.338 -6.866 1.00 16.29 ? 185 ASP A OD1 1 ATOM 1387 O OD2 . ASP A 1 185 ? 28.322 18.100 -7.536 1.00 17.09 ? 185 ASP A OD2 1 ATOM 1388 N N . ILE A 1 186 ? 30.086 19.271 -3.190 1.00 16.33 ? 186 ILE A N 1 ATOM 1389 C CA . ILE A 1 186 ? 31.014 20.312 -2.740 1.00 15.73 ? 186 ILE A CA 1 ATOM 1390 C C . ILE A 1 186 ? 31.954 20.835 -3.849 1.00 15.38 ? 186 ILE A C 1 ATOM 1391 O O . ILE A 1 186 ? 32.264 22.040 -3.886 1.00 14.54 ? 186 ILE A O 1 ATOM 1392 C CB . ILE A 1 186 ? 31.817 19.793 -1.531 1.00 15.81 ? 186 ILE A CB 1 ATOM 1393 C CG1 . ILE A 1 186 ? 30.865 19.575 -0.357 1.00 15.99 ? 186 ILE A CG1 1 ATOM 1394 C CG2 . ILE A 1 186 ? 32.910 20.781 -1.154 1.00 15.31 ? 186 ILE A CG2 1 ATOM 1395 C CD1 . ILE A 1 186 ? 31.458 18.751 0.766 1.00 16.96 ? 186 ILE A CD1 1 ATOM 1396 N N . ALA A 1 187 ? 32.397 19.959 -4.747 1.00 14.90 ? 187 ALA A N 1 ATOM 1397 C CA . ALA A 1 187 ? 33.281 20.391 -5.842 1.00 15.18 ? 187 ALA A CA 1 ATOM 1398 C C . ALA A 1 187 ? 32.598 21.418 -6.730 1.00 15.12 ? 187 ALA A C 1 ATOM 1399 O O . ALA A 1 187 ? 33.217 22.379 -7.142 1.00 14.52 ? 187 ALA A O 1 ATOM 1400 C CB . ALA A 1 187 ? 33.777 19.211 -6.677 1.00 15.03 ? 187 ALA A CB 1 ATOM 1401 N N . THR A 1 188 ? 31.333 21.177 -7.056 1.00 15.68 ? 188 THR A N 1 ATOM 1402 C CA . THR A 1 188 ? 30.532 22.155 -7.772 1.00 16.01 ? 188 THR A CA 1 ATOM 1403 C C . THR A 1 188 ? 30.395 23.451 -6.977 1.00 15.93 ? 188 THR A C 1 ATOM 1404 O O . THR A 1 188 ? 30.545 24.527 -7.536 1.00 16.40 ? 188 THR A O 1 ATOM 1405 C CB . THR A 1 188 ? 29.142 21.578 -8.055 1.00 16.33 ? 188 THR A CB 1 ATOM 1406 O OG1 . THR A 1 188 ? 29.269 20.391 -8.855 1.00 17.00 ? 188 THR A OG1 1 ATOM 1407 C CG2 . THR A 1 188 ? 28.301 22.539 -8.902 1.00 16.50 ? 188 THR A CG2 1 ATOM 1408 N N . GLN A 1 189 ? 30.087 23.335 -5.682 1.00 16.04 ? 189 GLN A N 1 ATOM 1409 C CA . GLN A 1 189 ? 29.952 24.499 -4.803 1.00 16.09 ? 189 GLN A CA 1 ATOM 1410 C C . GLN A 1 189 ? 31.247 25.309 -4.767 1.00 15.99 ? 189 GLN A C 1 ATOM 1411 O O . GLN A 1 189 ? 31.227 26.547 -4.766 1.00 15.91 ? 189 GLN A O 1 ATOM 1412 C CB . GLN A 1 189 ? 29.531 24.075 -3.394 1.00 15.71 ? 189 GLN A CB 1 ATOM 1413 C CG . GLN A 1 189 ? 28.141 23.422 -3.342 1.00 16.88 ? 189 GLN A CG 1 ATOM 1414 C CD . GLN A 1 189 ? 27.521 23.430 -1.961 1.00 16.60 ? 189 GLN A CD 1 ATOM 1415 O OE1 . GLN A 1 189 ? 26.840 22.480 -1.572 1.00 18.38 ? 189 GLN A OE1 1 ATOM 1416 N NE2 . GLN A 1 189 ? 27.720 24.516 -1.232 1.00 15.09 ? 189 GLN A NE2 1 ATOM 1417 N N . LEU A 1 190 ? 32.373 24.604 -4.810 1.00 15.79 ? 190 LEU A N 1 ATOM 1418 C CA . LEU A 1 190 ? 33.689 25.224 -4.854 1.00 16.47 ? 190 LEU A CA 1 ATOM 1419 C C . LEU A 1 190 ? 33.847 26.233 -5.990 1.00 16.96 ? 190 LEU A C 1 ATOM 1420 O O . LEU A 1 190 ? 34.435 27.317 -5.801 1.00 17.11 ? 190 LEU A O 1 ATOM 1421 C CB . LEU A 1 190 ? 34.764 24.135 -4.959 1.00 16.38 ? 190 LEU A CB 1 ATOM 1422 C CG . LEU A 1 190 ? 36.200 24.610 -5.201 1.00 16.53 ? 190 LEU A CG 1 ATOM 1423 C CD1 . LEU A 1 190 ? 36.735 25.349 -3.997 1.00 17.60 ? 190 LEU A CD1 1 ATOM 1424 C CD2 . LEU A 1 190 ? 37.088 23.400 -5.514 1.00 16.03 ? 190 LEU A CD2 1 ATOM 1425 N N . ILE A 1 191 ? 33.331 25.877 -7.163 1.00 17.51 ? 191 ILE A N 1 ATOM 1426 C CA . ILE A 1 191 ? 33.437 26.746 -8.347 1.00 18.07 ? 191 ILE A CA 1 ATOM 1427 C C . ILE A 1 191 ? 32.218 27.652 -8.576 1.00 18.79 ? 191 ILE A C 1 ATOM 1428 O O . ILE A 1 191 ? 32.309 28.593 -9.350 1.00 20.02 ? 191 ILE A O 1 ATOM 1429 C CB . ILE A 1 191 ? 33.747 25.925 -9.631 1.00 17.80 ? 191 ILE A CB 1 ATOM 1430 C CG1 . ILE A 1 191 ? 32.537 25.115 -10.107 1.00 18.18 ? 191 ILE A CG1 1 ATOM 1431 C CG2 . ILE A 1 191 ? 34.952 25.019 -9.431 1.00 18.52 ? 191 ILE A CG2 1 ATOM 1432 C CD1 . ILE A 1 191 ? 32.536 24.909 -11.593 1.00 19.69 ? 191 ILE A CD1 1 ATOM 1433 N N . SER A 1 192 ? 31.096 27.396 -7.906 1.00 19.33 ? 192 SER A N 1 ATOM 1434 C CA . SER A 1 192 ? 29.845 28.104 -8.223 1.00 19.99 ? 192 SER A CA 1 ATOM 1435 C C . SER A 1 192 ? 29.370 29.089 -7.158 1.00 19.55 ? 192 SER A C 1 ATOM 1436 O O . SER A 1 192 ? 28.807 30.139 -7.495 1.00 19.63 ? 192 SER A O 1 ATOM 1437 C CB . SER A 1 192 ? 28.723 27.092 -8.493 1.00 20.34 ? 192 SER A CB 1 ATOM 1438 O OG . SER A 1 192 ? 29.103 26.194 -9.512 1.00 23.82 ? 192 SER A OG 1 ATOM 1439 N N . ASN A 1 193 ? 29.573 28.758 -5.881 1.00 18.54 ? 193 ASN A N 1 ATOM 1440 C CA . ASN A 1 193 ? 28.954 29.521 -4.807 1.00 18.36 ? 193 ASN A CA 1 ATOM 1441 C C . ASN A 1 193 ? 29.502 30.927 -4.765 1.00 18.15 ? 193 ASN A C 1 ATOM 1442 O O . ASN A 1 193 ? 28.756 31.899 -4.629 1.00 18.45 ? 193 ASN A O 1 ATOM 1443 C CB . ASN A 1 193 ? 29.180 28.855 -3.437 1.00 18.36 ? 193 ASN A CB 1 ATOM 1444 C CG . ASN A 1 193 ? 28.300 27.643 -3.197 1.00 18.55 ? 193 ASN A CG 1 ATOM 1445 O OD1 . ASN A 1 193 ? 28.260 27.115 -2.069 1.00 19.26 ? 193 ASN A OD1 1 ATOM 1446 N ND2 . ASN A 1 193 ? 27.586 27.199 -4.218 1.00 15.54 ? 193 ASN A ND2 1 ATOM 1447 N N . MET A 1 194 ? 30.818 31.041 -4.860 1.00 17.67 ? 194 MET A N 1 ATOM 1448 C CA . MET A 1 194 ? 31.454 32.330 -4.808 1.00 17.62 ? 194 MET A CA 1 ATOM 1449 C C . MET A 1 194 ? 32.743 32.340 -5.600 1.00 17.59 ? 194 MET A C 1 ATOM 1450 O O . MET A 1 194 ? 33.296 31.292 -5.944 1.00 17.88 ? 194 MET A O 1 ATOM 1451 C CB . MET A 1 194 ? 31.735 32.719 -3.354 1.00 17.41 ? 194 MET A CB 1 ATOM 1452 C CG . MET A 1 194 ? 32.640 31.751 -2.630 1.00 17.41 ? 194 MET A CG 1 ATOM 1453 S SD . MET A 1 194 ? 33.111 32.312 -0.993 1.00 17.05 ? 194 MET A SD 1 ATOM 1454 C CE . MET A 1 194 ? 34.206 33.667 -1.336 1.00 17.18 ? 194 MET A CE 1 ATOM 1455 N N . ASP A 1 195 ? 33.207 33.547 -5.872 1.00 17.41 ? 195 ASP A N 1 ATOM 1456 C CA . ASP A 1 195 ? 34.492 33.765 -6.491 1.00 17.51 ? 195 ASP A CA 1 ATOM 1457 C C . ASP A 1 195 ? 35.589 33.555 -5.463 1.00 16.54 ? 195 ASP A C 1 ATOM 1458 O O . ASP A 1 195 ? 35.542 34.131 -4.386 1.00 16.75 ? 195 ASP A O 1 ATOM 1459 C CB . ASP A 1 195 ? 34.577 35.185 -7.027 1.00 17.84 ? 195 ASP A CB 1 ATOM 1460 C CG . ASP A 1 195 ? 35.893 35.458 -7.705 1.00 19.68 ? 195 ASP A CG 1 ATOM 1461 O OD1 . ASP A 1 195 ? 36.350 34.582 -8.463 1.00 21.50 ? 195 ASP A OD1 1 ATOM 1462 O OD2 . ASP A 1 195 ? 36.545 36.505 -7.528 1.00 23.65 ? 195 ASP A OD2 1 ATOM 1463 N N . ILE A 1 196 ? 36.548 32.699 -5.784 1.00 16.29 ? 196 ILE A N 1 ATOM 1464 C CA . ILE A 1 196 ? 37.686 32.430 -4.905 1.00 16.02 ? 196 ILE A CA 1 ATOM 1465 C C . ILE A 1 196 ? 38.938 32.615 -5.747 1.00 15.98 ? 196 ILE A C 1 ATOM 1466 O O . ILE A 1 196 ? 39.074 31.997 -6.798 1.00 16.53 ? 196 ILE A O 1 ATOM 1467 C CB . ILE A 1 196 ? 37.623 30.993 -4.327 1.00 15.69 ? 196 ILE A CB 1 ATOM 1468 C CG1 . ILE A 1 196 ? 36.310 30.775 -3.575 1.00 16.06 ? 196 ILE A CG1 1 ATOM 1469 C CG2 . ILE A 1 196 ? 38.758 30.753 -3.375 1.00 16.67 ? 196 ILE A CG2 1 ATOM 1470 C CD1 . ILE A 1 196 ? 36.065 29.323 -3.166 1.00 15.88 ? 196 ILE A CD1 1 ATOM 1471 N N . ASP A 1 197 ? 39.826 33.488 -5.290 1.00 15.88 ? 197 ASP A N 1 ATOM 1472 C CA . ASP A 1 197 ? 40.987 33.902 -6.071 1.00 16.27 ? 197 ASP A CA 1 ATOM 1473 C C . ASP A 1 197 ? 42.073 32.845 -6.090 1.00 15.80 ? 197 ASP A C 1 ATOM 1474 O O . ASP A 1 197 ? 42.741 32.660 -7.105 1.00 16.04 ? 197 ASP A O 1 ATOM 1475 C CB . ASP A 1 197 ? 41.556 35.201 -5.510 1.00 16.42 ? 197 ASP A CB 1 ATOM 1476 C CG . ASP A 1 197 ? 40.535 36.314 -5.493 1.00 17.21 ? 197 ASP A CG 1 ATOM 1477 O OD1 . ASP A 1 197 ? 40.487 37.071 -6.475 1.00 20.09 ? 197 ASP A OD1 1 ATOM 1478 O OD2 . ASP A 1 197 ? 39.733 36.488 -4.559 1.00 16.77 ? 197 ASP A OD2 1 ATOM 1479 N N . VAL A 1 198 ? 42.240 32.153 -4.964 1.00 15.33 ? 198 VAL A N 1 ATOM 1480 C CA . VAL A 1 198 ? 43.274 31.147 -4.811 1.00 15.44 ? 198 VAL A CA 1 ATOM 1481 C C . VAL A 1 198 ? 42.699 29.927 -4.145 1.00 14.77 ? 198 VAL A C 1 ATOM 1482 O O . VAL A 1 198 ? 42.099 30.038 -3.087 1.00 15.05 ? 198 VAL A O 1 ATOM 1483 C CB . VAL A 1 198 ? 44.429 31.659 -3.952 1.00 15.50 ? 198 VAL A CB 1 ATOM 1484 C CG1 . VAL A 1 198 ? 45.468 30.568 -3.733 1.00 16.80 ? 198 VAL A CG1 1 ATOM 1485 C CG2 . VAL A 1 198 ? 45.064 32.869 -4.615 1.00 16.45 ? 198 VAL A CG2 1 ATOM 1486 N N . ILE A 1 199 ? 42.889 28.777 -4.777 1.00 13.75 ? 199 ILE A N 1 ATOM 1487 C CA . ILE A 1 199 ? 42.459 27.491 -4.248 1.00 14.00 ? 199 ILE A CA 1 ATOM 1488 C C . ILE A 1 199 ? 43.628 26.521 -4.370 1.00 13.86 ? 199 ILE A C 1 ATOM 1489 O O . ILE A 1 199 ? 43.993 26.122 -5.460 1.00 13.93 ? 199 ILE A O 1 ATOM 1490 C CB . ILE A 1 199 ? 41.259 26.951 -5.058 1.00 14.00 ? 199 ILE A CB 1 ATOM 1491 C CG1 . ILE A 1 199 ? 40.033 27.839 -4.888 1.00 14.33 ? 199 ILE A CG1 1 ATOM 1492 C CG2 . ILE A 1 199 ? 40.920 25.541 -4.644 1.00 14.36 ? 199 ILE A CG2 1 ATOM 1493 C CD1 . ILE A 1 199 ? 39.047 27.677 -6.044 1.00 15.29 ? 199 ILE A CD1 1 ATOM 1494 N N . LEU A 1 200 ? 44.222 26.148 -3.247 1.00 13.90 ? 200 LEU A N 1 ATOM 1495 C CA . LEU A 1 200 ? 45.392 25.293 -3.267 1.00 13.54 ? 200 LEU A CA 1 ATOM 1496 C C . LEU A 1 200 ? 45.227 24.145 -2.292 1.00 13.70 ? 200 LEU A C 1 ATOM 1497 O O . LEU A 1 200 ? 44.967 24.354 -1.123 1.00 14.25 ? 200 LEU A O 1 ATOM 1498 C CB . LEU A 1 200 ? 46.631 26.102 -2.899 1.00 12.68 ? 200 LEU A CB 1 ATOM 1499 C CG . LEU A 1 200 ? 47.003 27.248 -3.824 1.00 12.76 ? 200 LEU A CG 1 ATOM 1500 C CD1 . LEU A 1 200 ? 48.160 28.020 -3.252 1.00 12.11 ? 200 LEU A CD1 1 ATOM 1501 C CD2 . LEU A 1 200 ? 47.347 26.733 -5.223 1.00 10.46 ? 200 LEU A CD2 1 ATOM 1502 N N . GLY A 1 201 ? 45.395 22.930 -2.792 1.00 14.11 ? 201 GLY A N 1 ATOM 1503 C CA . GLY A 1 201 ? 45.405 21.750 -1.972 1.00 13.96 ? 201 GLY A CA 1 ATOM 1504 C C . GLY A 1 201 ? 45.199 20.536 -2.832 1.00 14.73 ? 201 GLY A C 1 ATOM 1505 O O . GLY A 1 201 ? 45.592 20.531 -3.998 1.00 14.98 ? 201 GLY A O 1 ATOM 1506 N N . GLY A 1 202 ? 44.599 19.492 -2.260 1.00 14.52 ? 202 GLY A N 1 ATOM 1507 C CA . GLY A 1 202 ? 44.285 18.299 -3.020 1.00 14.28 ? 202 GLY A CA 1 ATOM 1508 C C . GLY A 1 202 ? 42.882 18.343 -3.584 1.00 14.75 ? 202 GLY A C 1 ATOM 1509 O O . GLY A 1 202 ? 42.200 19.375 -3.513 1.00 14.72 ? 202 GLY A O 1 ATOM 1510 N N . GLY A 1 203 ? 42.451 17.213 -4.130 1.00 14.86 ? 203 GLY A N 1 ATOM 1511 C CA . GLY A 1 203 ? 41.081 17.022 -4.545 1.00 15.95 ? 203 GLY A CA 1 ATOM 1512 C C . GLY A 1 203 ? 40.868 17.129 -6.038 1.00 16.71 ? 203 GLY A C 1 ATOM 1513 O O . GLY A 1 203 ? 39.768 17.457 -6.480 1.00 17.06 ? 203 GLY A O 1 ATOM 1514 N N . ARG A 1 204 ? 41.903 16.845 -6.824 1.00 17.53 ? 204 ARG A N 1 ATOM 1515 C CA . ARG A 1 204 ? 41.763 16.819 -8.287 1.00 18.19 ? 204 ARG A CA 1 ATOM 1516 C C . ARG A 1 204 ? 40.586 15.995 -8.786 1.00 18.68 ? 204 ARG A C 1 ATOM 1517 O O . ARG A 1 204 ? 39.842 16.447 -9.656 1.00 19.33 ? 204 ARG A O 1 ATOM 1518 C CB . ARG A 1 204 ? 43.031 16.283 -8.957 1.00 18.56 ? 204 ARG A CB 1 ATOM 1519 C CG . ARG A 1 204 ? 44.025 17.335 -9.354 1.00 18.66 ? 204 ARG A CG 1 ATOM 1520 C CD . ARG A 1 204 ? 45.125 16.840 -10.315 1.00 18.32 ? 204 ARG A CD 1 ATOM 1521 N NE . ARG A 1 204 ? 45.816 15.628 -9.859 1.00 18.19 ? 204 ARG A NE 1 ATOM 1522 C CZ . ARG A 1 204 ? 47.027 15.578 -9.301 1.00 17.91 ? 204 ARG A CZ 1 ATOM 1523 N NH1 . ARG A 1 204 ? 47.548 14.412 -8.946 1.00 18.64 ? 204 ARG A NH1 1 ATOM 1524 N NH2 . ARG A 1 204 ? 47.720 16.674 -9.072 1.00 18.78 ? 204 ARG A NH2 1 ATOM 1525 N N . LYS A 1 205 ? 40.418 14.794 -8.230 1.00 19.35 ? 205 LYS A N 1 ATOM 1526 C CA . LYS A 1 205 ? 39.560 13.772 -8.814 1.00 20.06 ? 205 LYS A CA 1 ATOM 1527 C C . LYS A 1 205 ? 38.096 14.155 -8.943 1.00 19.69 ? 205 LYS A C 1 ATOM 1528 O O . LYS A 1 205 ? 37.435 13.768 -9.898 1.00 19.70 ? 205 LYS A O 1 ATOM 1529 C CB . LYS A 1 205 ? 39.680 12.451 -8.044 1.00 19.87 ? 205 LYS A CB 1 ATOM 1530 C CG . LYS A 1 205 ? 39.253 12.472 -6.588 1.00 21.49 ? 205 LYS A CG 1 ATOM 1531 C CD . LYS A 1 205 ? 39.355 11.067 -6.009 1.00 21.88 ? 205 LYS A CD 1 ATOM 1532 C CE . LYS A 1 205 ? 39.655 11.065 -4.537 1.00 24.98 ? 205 LYS A CE 1 ATOM 1533 N NZ . LYS A 1 205 ? 39.962 9.675 -4.109 1.00 26.43 ? 205 LYS A NZ 1 ATOM 1534 N N . TYR A 1 206 ? 37.613 14.945 -7.989 1.00 19.46 ? 206 TYR A N 1 ATOM 1535 C CA . TYR A 1 206 ? 36.204 15.323 -7.938 1.00 19.16 ? 206 TYR A CA 1 ATOM 1536 C C . TYR A 1 206 ? 35.820 16.356 -8.989 1.00 18.84 ? 206 TYR A C 1 ATOM 1537 O O . TYR A 1 206 ? 34.643 16.664 -9.144 1.00 18.31 ? 206 TYR A O 1 ATOM 1538 C CB . TYR A 1 206 ? 35.881 15.902 -6.572 1.00 18.78 ? 206 TYR A CB 1 ATOM 1539 C CG . TYR A 1 206 ? 36.275 15.014 -5.423 1.00 19.04 ? 206 TYR A CG 1 ATOM 1540 C CD1 . TYR A 1 206 ? 37.170 15.462 -4.455 1.00 19.26 ? 206 TYR A CD1 1 ATOM 1541 C CD2 . TYR A 1 206 ? 35.755 13.735 -5.295 1.00 18.04 ? 206 TYR A CD2 1 ATOM 1542 C CE1 . TYR A 1 206 ? 37.522 14.670 -3.387 1.00 19.38 ? 206 TYR A CE1 1 ATOM 1543 C CE2 . TYR A 1 206 ? 36.107 12.927 -4.226 1.00 19.21 ? 206 TYR A CE2 1 ATOM 1544 C CZ . TYR A 1 206 ? 37.008 13.408 -3.272 1.00 19.07 ? 206 TYR A CZ 1 ATOM 1545 O OH . TYR A 1 206 ? 37.376 12.628 -2.193 1.00 18.73 ? 206 TYR A OH 1 ATOM 1546 N N . MET A 1 207 ? 36.810 16.895 -9.689 1.00 18.51 ? 207 MET A N 1 ATOM 1547 C CA . MET A 1 207 ? 36.593 17.973 -10.654 1.00 18.61 ? 207 MET A CA 1 ATOM 1548 C C . MET A 1 207 ? 36.422 17.481 -12.092 1.00 19.25 ? 207 MET A C 1 ATOM 1549 O O . MET A 1 207 ? 36.124 18.273 -12.989 1.00 18.16 ? 207 MET A O 1 ATOM 1550 C CB . MET A 1 207 ? 37.790 18.926 -10.631 1.00 18.11 ? 207 MET A CB 1 ATOM 1551 C CG . MET A 1 207 ? 38.198 19.425 -9.258 1.00 17.37 ? 207 MET A CG 1 ATOM 1552 S SD . MET A 1 207 ? 36.887 20.390 -8.513 1.00 17.60 ? 207 MET A SD 1 ATOM 1553 C CE . MET A 1 207 ? 37.116 21.945 -9.341 1.00 17.13 ? 207 MET A CE 1 ATOM 1554 N N . PHE A 1 208 ? 36.642 16.191 -12.316 1.00 20.08 ? 208 PHE A N 1 ATOM 1555 C CA . PHE A 1 208 ? 36.724 15.654 -13.676 1.00 21.48 ? 208 PHE A CA 1 ATOM 1556 C C . PHE A 1 208 ? 35.828 14.441 -13.822 1.00 22.78 ? 208 PHE A C 1 ATOM 1557 O O . PHE A 1 208 ? 35.577 13.707 -12.867 1.00 21.88 ? 208 PHE A O 1 ATOM 1558 C CB . PHE A 1 208 ? 38.168 15.273 -14.051 1.00 21.55 ? 208 PHE A CB 1 ATOM 1559 C CG . PHE A 1 208 ? 39.143 16.412 -13.987 1.00 21.84 ? 208 PHE A CG 1 ATOM 1560 C CD1 . PHE A 1 208 ? 39.246 17.323 -15.032 1.00 22.58 ? 208 PHE A CD1 1 ATOM 1561 C CD2 . PHE A 1 208 ? 39.975 16.571 -12.880 1.00 22.23 ? 208 PHE A CD2 1 ATOM 1562 C CE1 . PHE A 1 208 ? 40.148 18.374 -14.969 1.00 22.63 ? 208 PHE A CE1 1 ATOM 1563 C CE2 . PHE A 1 208 ? 40.885 17.600 -12.819 1.00 21.63 ? 208 PHE A CE2 1 ATOM 1564 C CZ . PHE A 1 208 ? 40.974 18.510 -13.855 1.00 22.47 ? 208 PHE A CZ 1 ATOM 1565 N N . ARG A 1 209 ? 35.356 14.213 -15.039 1.00 24.96 ? 209 ARG A N 1 ATOM 1566 C CA . ARG A 1 209 ? 34.459 13.102 -15.259 1.00 26.87 ? 209 ARG A CA 1 ATOM 1567 C C . ARG A 1 209 ? 35.177 11.768 -15.138 1.00 27.28 ? 209 ARG A C 1 ATOM 1568 O O . ARG A 1 209 ? 36.392 11.670 -15.312 1.00 26.76 ? 209 ARG A O 1 ATOM 1569 C CB . ARG A 1 209 ? 33.737 13.219 -16.604 1.00 27.07 ? 209 ARG A CB 1 ATOM 1570 C CG . ARG A 1 209 ? 34.610 13.334 -17.802 1.00 28.73 ? 209 ARG A CG 1 ATOM 1571 C CD . ARG A 1 209 ? 33.796 13.452 -19.083 1.00 30.71 ? 209 ARG A CD 1 ATOM 1572 N NE . ARG A 1 209 ? 34.629 13.366 -20.280 1.00 34.39 ? 209 ARG A NE 1 ATOM 1573 C CZ . ARG A 1 209 ? 34.149 13.275 -21.515 1.00 36.44 ? 209 ARG A CZ 1 ATOM 1574 N NH1 . ARG A 1 209 ? 32.827 13.248 -21.728 1.00 38.34 ? 209 ARG A NH1 1 ATOM 1575 N NH2 . ARG A 1 209 ? 34.993 13.206 -22.546 1.00 37.16 ? 209 ARG A NH2 1 ATOM 1576 N N . MET A 1 210 ? 34.402 10.750 -14.798 1.00 28.72 ? 210 MET A N 1 ATOM 1577 C CA . MET A 1 210 ? 34.894 9.383 -14.767 1.00 30.50 ? 210 MET A CA 1 ATOM 1578 C C . MET A 1 210 ? 35.488 9.023 -16.130 1.00 29.78 ? 210 MET A C 1 ATOM 1579 O O . MET A 1 210 ? 34.943 9.393 -17.175 1.00 29.46 ? 210 MET A O 1 ATOM 1580 C CB . MET A 1 210 ? 33.751 8.449 -14.387 1.00 30.39 ? 210 MET A CB 1 ATOM 1581 C CG . MET A 1 210 ? 34.079 6.973 -14.464 1.00 32.48 ? 210 MET A CG 1 ATOM 1582 S SD . MET A 1 210 ? 32.736 5.923 -13.855 1.00 35.75 ? 210 MET A SD 1 ATOM 1583 C CE . MET A 1 210 ? 31.735 7.008 -12.818 1.00 36.36 ? 210 MET A CE 1 ATOM 1584 N N . GLY A 1 211 ? 36.630 8.339 -16.102 1.00 29.52 ? 211 GLY A N 1 ATOM 1585 C CA . GLY A 1 211 ? 37.402 8.078 -17.305 1.00 29.37 ? 211 GLY A CA 1 ATOM 1586 C C . GLY A 1 211 ? 38.609 8.990 -17.427 1.00 29.04 ? 211 GLY A C 1 ATOM 1587 O O . GLY A 1 211 ? 39.590 8.614 -18.065 1.00 29.49 ? 211 GLY A O 1 ATOM 1588 N N . THR A 1 212 ? 38.548 10.182 -16.823 1.00 28.18 ? 212 THR A N 1 ATOM 1589 C CA . THR A 1 212 ? 39.646 11.148 -16.924 1.00 27.29 ? 212 THR A CA 1 ATOM 1590 C C . THR A 1 212 ? 40.865 10.667 -16.140 1.00 27.19 ? 212 THR A C 1 ATOM 1591 O O . THR A 1 212 ? 40.825 10.595 -14.915 1.00 25.87 ? 212 THR A O 1 ATOM 1592 C CB . THR A 1 212 ? 39.228 12.540 -16.403 1.00 27.37 ? 212 THR A CB 1 ATOM 1593 O OG1 . THR A 1 212 ? 38.044 12.992 -17.074 1.00 25.97 ? 212 THR A OG1 1 ATOM 1594 C CG2 . THR A 1 212 ? 40.280 13.585 -16.752 1.00 27.35 ? 212 THR A CG2 1 ATOM 1595 N N . PRO A 1 213 ? 41.962 10.367 -16.834 1.00 26.90 ? 213 PRO A N 1 ATOM 1596 C CA . PRO A 1 213 ? 43.184 9.993 -16.145 1.00 26.86 ? 213 PRO A CA 1 ATOM 1597 C C . PRO A 1 213 ? 43.706 11.166 -15.319 1.00 26.65 ? 213 PRO A C 1 ATOM 1598 O O . PRO A 1 213 ? 43.741 12.297 -15.799 1.00 26.68 ? 213 PRO A O 1 ATOM 1599 C CB . PRO A 1 213 ? 44.156 9.660 -17.289 1.00 26.57 ? 213 PRO A CB 1 ATOM 1600 C CG . PRO A 1 213 ? 43.324 9.477 -18.462 1.00 27.02 ? 213 PRO A CG 1 ATOM 1601 C CD . PRO A 1 213 ? 42.149 10.385 -18.295 1.00 27.20 ? 213 PRO A CD 1 ATOM 1602 N N . ASP A 1 214 ? 44.072 10.904 -14.076 1.00 26.96 ? 214 ASP A N 1 ATOM 1603 C CA . ASP A 1 214 ? 44.791 11.892 -13.284 1.00 27.02 ? 214 ASP A CA 1 ATOM 1604 C C . ASP A 1 214 ? 46.123 12.164 -13.986 1.00 27.21 ? 214 ASP A C 1 ATOM 1605 O O . ASP A 1 214 ? 46.780 11.214 -14.396 1.00 27.57 ? 214 ASP A O 1 ATOM 1606 C CB . ASP A 1 214 ? 45.047 11.338 -11.888 1.00 26.86 ? 214 ASP A CB 1 ATOM 1607 C CG . ASP A 1 214 ? 45.643 12.357 -10.965 1.00 26.72 ? 214 ASP A CG 1 ATOM 1608 O OD1 . ASP A 1 214 ? 46.887 12.363 -10.790 1.00 24.45 ? 214 ASP A OD1 1 ATOM 1609 O OD2 . ASP A 1 214 ? 44.936 13.202 -10.383 1.00 26.31 ? 214 ASP A OD2 1 ATOM 1610 N N . PRO A 1 215 ? 46.544 13.428 -14.114 1.00 27.56 ? 215 PRO A N 1 ATOM 1611 C CA . PRO A 1 215 ? 47.763 13.747 -14.867 1.00 27.38 ? 215 PRO A CA 1 ATOM 1612 C C . PRO A 1 215 ? 49.040 13.237 -14.208 1.00 27.44 ? 215 PRO A C 1 ATOM 1613 O O . PRO A 1 215 ? 50.029 12.991 -14.888 1.00 27.37 ? 215 PRO A O 1 ATOM 1614 C CB . PRO A 1 215 ? 47.766 15.288 -14.902 1.00 27.71 ? 215 PRO A CB 1 ATOM 1615 C CG . PRO A 1 215 ? 46.984 15.695 -13.697 1.00 27.59 ? 215 PRO A CG 1 ATOM 1616 C CD . PRO A 1 215 ? 45.914 14.645 -13.564 1.00 27.66 ? 215 PRO A CD 1 ATOM 1617 N N . GLU A 1 216 ? 49.013 13.081 -12.892 1.00 27.23 ? 216 GLU A N 1 ATOM 1618 C CA . GLU A 1 216 ? 50.190 12.689 -12.145 1.00 27.08 ? 216 GLU A CA 1 ATOM 1619 C C . GLU A 1 216 ? 50.234 11.180 -11.915 1.00 27.47 ? 216 GLU A C 1 ATOM 1620 O O . GLU A 1 216 ? 51.309 10.606 -11.753 1.00 27.96 ? 216 GLU A O 1 ATOM 1621 C CB . GLU A 1 216 ? 50.186 13.430 -10.811 1.00 27.02 ? 216 GLU A CB 1 ATOM 1622 C CG . GLU A 1 216 ? 51.442 13.268 -9.976 1.00 26.28 ? 216 GLU A CG 1 ATOM 1623 C CD . GLU A 1 216 ? 51.402 14.125 -8.728 1.00 25.20 ? 216 GLU A CD 1 ATOM 1624 O OE1 . GLU A 1 216 ? 50.347 14.734 -8.433 1.00 20.88 ? 216 GLU A OE1 1 ATOM 1625 O OE2 . GLU A 1 216 ? 52.429 14.215 -8.046 1.00 21.28 ? 216 GLU A OE2 1 ATOM 1626 N N . TYR A 1 217 ? 49.069 10.543 -11.871 1.00 27.60 ? 217 TYR A N 1 ATOM 1627 C CA . TYR A 1 217 ? 48.978 9.090 -11.742 1.00 28.01 ? 217 TYR A CA 1 ATOM 1628 C C . TYR A 1 217 ? 48.126 8.498 -12.875 1.00 28.81 ? 217 TYR A C 1 ATOM 1629 O O . TYR A 1 217 ? 47.150 7.796 -12.614 1.00 28.51 ? 217 TYR A O 1 ATOM 1630 C CB . TYR A 1 217 ? 48.388 8.726 -10.381 1.00 28.00 ? 217 TYR A CB 1 ATOM 1631 C CG . TYR A 1 217 ? 49.082 9.426 -9.235 1.00 27.51 ? 217 TYR A CG 1 ATOM 1632 C CD1 . TYR A 1 217 ? 50.287 8.939 -8.725 1.00 27.80 ? 217 TYR A CD1 1 ATOM 1633 C CD2 . TYR A 1 217 ? 48.554 10.585 -8.671 1.00 27.37 ? 217 TYR A CD2 1 ATOM 1634 C CE1 . TYR A 1 217 ? 50.939 9.581 -7.678 1.00 26.88 ? 217 TYR A CE1 1 ATOM 1635 C CE2 . TYR A 1 217 ? 49.204 11.237 -7.617 1.00 27.07 ? 217 TYR A CE2 1 ATOM 1636 C CZ . TYR A 1 217 ? 50.392 10.723 -7.126 1.00 27.74 ? 217 TYR A CZ 1 ATOM 1637 O OH . TYR A 1 217 ? 51.044 11.344 -6.087 1.00 26.74 ? 217 TYR A OH 1 ATOM 1638 N N . PRO A 1 218 ? 48.507 8.755 -14.133 1.00 29.69 ? 218 PRO A N 1 ATOM 1639 C CA . PRO A 1 218 ? 47.698 8.326 -15.287 1.00 30.28 ? 218 PRO A CA 1 ATOM 1640 C C . PRO A 1 218 ? 47.489 6.810 -15.373 1.00 30.76 ? 218 PRO A C 1 ATOM 1641 O O . PRO A 1 218 ? 46.610 6.354 -16.111 1.00 31.40 ? 218 PRO A O 1 ATOM 1642 C CB . PRO A 1 218 ? 48.501 8.826 -16.492 1.00 30.32 ? 218 PRO A CB 1 ATOM 1643 C CG . PRO A 1 218 ? 49.890 8.997 -15.981 1.00 30.46 ? 218 PRO A CG 1 ATOM 1644 C CD . PRO A 1 218 ? 49.743 9.433 -14.558 1.00 29.70 ? 218 PRO A CD 1 ATOM 1645 N N . ASP A 1 219 ? 48.274 6.049 -14.615 1.00 30.89 ? 219 ASP A N 1 ATOM 1646 C CA . ASP A 1 219 ? 48.203 4.596 -14.625 1.00 31.21 ? 219 ASP A CA 1 ATOM 1647 C C . ASP A 1 219 ? 47.534 3.998 -13.392 1.00 30.84 ? 219 ASP A C 1 ATOM 1648 O O . ASP A 1 219 ? 47.574 2.785 -13.208 1.00 31.24 ? 219 ASP A O 1 ATOM 1649 C CB . ASP A 1 219 ? 49.613 4.020 -14.793 1.00 31.66 ? 219 ASP A CB 1 ATOM 1650 C CG . ASP A 1 219 ? 50.614 4.641 -13.844 1.00 33.29 ? 219 ASP A CG 1 ATOM 1651 O OD1 . ASP A 1 219 ? 51.757 4.902 -14.286 1.00 36.01 ? 219 ASP A OD1 1 ATOM 1652 O OD2 . ASP A 1 219 ? 50.339 4.930 -12.658 1.00 34.38 ? 219 ASP A OD2 1 ATOM 1653 N N . ASP A 1 220 ? 46.932 4.829 -12.540 1.00 29.99 ? 220 ASP A N 1 ATOM 1654 C CA . ASP A 1 220 ? 46.152 4.329 -11.405 1.00 29.42 ? 220 ASP A CA 1 ATOM 1655 C C . ASP A 1 220 ? 44.729 4.852 -11.534 1.00 28.42 ? 220 ASP A C 1 ATOM 1656 O O . ASP A 1 220 ? 44.489 6.034 -11.293 1.00 28.59 ? 220 ASP A O 1 ATOM 1657 C CB . ASP A 1 220 ? 46.772 4.791 -10.088 1.00 29.46 ? 220 ASP A CB 1 ATOM 1658 C CG . ASP A 1 220 ? 45.998 4.315 -8.873 1.00 30.43 ? 220 ASP A CG 1 ATOM 1659 O OD1 . ASP A 1 220 ? 46.422 4.672 -7.746 1.00 31.83 ? 220 ASP A OD1 1 ATOM 1660 O OD2 . ASP A 1 220 ? 44.960 3.608 -8.932 1.00 29.30 ? 220 ASP A OD2 1 ATOM 1661 N N . TYR A 1 221 ? 43.798 3.975 -11.924 1.00 26.98 ? 221 TYR A N 1 ATOM 1662 C CA . TYR A 1 221 ? 42.445 4.400 -12.289 1.00 25.63 ? 221 TYR A CA 1 ATOM 1663 C C . TYR A 1 221 ? 41.660 4.901 -11.087 1.00 25.49 ? 221 TYR A C 1 ATOM 1664 O O . TYR A 1 221 ? 40.783 5.750 -11.234 1.00 24.89 ? 221 TYR A O 1 ATOM 1665 C CB . TYR A 1 221 ? 41.650 3.273 -12.949 1.00 24.88 ? 221 TYR A CB 1 ATOM 1666 C CG . TYR A 1 221 ? 42.166 2.757 -14.280 1.00 23.18 ? 221 TYR A CG 1 ATOM 1667 C CD1 . TYR A 1 221 ? 43.177 3.409 -14.994 1.00 23.04 ? 221 TYR A CD1 1 ATOM 1668 C CD2 . TYR A 1 221 ? 41.596 1.629 -14.847 1.00 22.91 ? 221 TYR A CD2 1 ATOM 1669 C CE1 . TYR A 1 221 ? 43.615 2.914 -16.219 1.00 22.95 ? 221 TYR A CE1 1 ATOM 1670 C CE2 . TYR A 1 221 ? 42.011 1.140 -16.057 1.00 21.90 ? 221 TYR A CE2 1 ATOM 1671 C CZ . TYR A 1 221 ? 43.019 1.772 -16.749 1.00 21.97 ? 221 TYR A CZ 1 ATOM 1672 O OH . TYR A 1 221 ? 43.438 1.241 -17.954 1.00 21.62 ? 221 TYR A OH 1 ATOM 1673 N N . SER A 1 222 ? 41.968 4.371 -9.903 1.00 25.61 ? 222 SER A N 1 ATOM 1674 C CA . SER A 1 222 ? 41.306 4.823 -8.668 1.00 25.61 ? 222 SER A CA 1 ATOM 1675 C C . SER A 1 222 ? 41.557 6.302 -8.366 1.00 25.33 ? 222 SER A C 1 ATOM 1676 O O . SER A 1 222 ? 40.815 6.893 -7.589 1.00 25.65 ? 222 SER A O 1 ATOM 1677 C CB . SER A 1 222 ? 41.751 3.988 -7.476 1.00 25.72 ? 222 SER A CB 1 ATOM 1678 O OG . SER A 1 222 ? 43.132 4.180 -7.227 1.00 26.41 ? 222 SER A OG 1 ATOM 1679 N N . GLN A 1 223 ? 42.590 6.878 -8.984 1.00 25.05 ? 223 GLN A N 1 ATOM 1680 C CA . GLN A 1 223 ? 42.950 8.291 -8.841 1.00 25.15 ? 223 GLN A CA 1 ATOM 1681 C C . GLN A 1 223 ? 42.308 9.201 -9.885 1.00 24.51 ? 223 GLN A C 1 ATOM 1682 O O . GLN A 1 223 ? 42.438 10.421 -9.803 1.00 24.47 ? 223 GLN A O 1 ATOM 1683 C CB . GLN A 1 223 ? 44.467 8.451 -8.946 1.00 25.23 ? 223 GLN A CB 1 ATOM 1684 C CG . GLN A 1 223 ? 45.238 7.581 -7.972 1.00 26.86 ? 223 GLN A CG 1 ATOM 1685 C CD . GLN A 1 223 ? 44.742 7.744 -6.548 1.00 29.30 ? 223 GLN A CD 1 ATOM 1686 O OE1 . GLN A 1 223 ? 44.666 8.856 -6.048 1.00 29.86 ? 223 GLN A OE1 1 ATOM 1687 N NE2 . GLN A 1 223 ? 44.378 6.639 -5.906 1.00 30.44 ? 223 GLN A NE2 1 ATOM 1688 N N . GLY A 1 224 ? 41.639 8.614 -10.874 1.00 23.76 ? 224 GLY A N 1 ATOM 1689 C CA . GLY A 1 224 ? 41.025 9.384 -11.952 1.00 23.18 ? 224 GLY A CA 1 ATOM 1690 C C . GLY A 1 224 ? 39.781 10.111 -11.504 1.00 22.67 ? 224 GLY A C 1 ATOM 1691 O O . GLY A 1 224 ? 39.411 10.045 -10.332 1.00 22.29 ? 224 GLY A O 1 ATOM 1692 N N . GLY A 1 225 ? 39.131 10.791 -12.448 1.00 22.15 ? 225 GLY A N 1 ATOM 1693 C CA . GLY A 1 225 ? 37.901 11.531 -12.186 1.00 21.84 ? 225 GLY A CA 1 ATOM 1694 C C . GLY A 1 225 ? 36.771 10.673 -11.651 1.00 21.94 ? 225 GLY A C 1 ATOM 1695 O O . GLY A 1 225 ? 36.678 9.476 -11.939 1.00 21.74 ? 225 GLY A O 1 ATOM 1696 N N . THR A 1 226 ? 35.899 11.300 -10.871 1.00 21.57 ? 226 THR A N 1 ATOM 1697 C CA . THR A 1 226 ? 34.828 10.605 -10.194 1.00 21.20 ? 226 THR A CA 1 ATOM 1698 C C . THR A 1 226 ? 33.451 10.999 -10.699 1.00 21.52 ? 226 THR A C 1 ATOM 1699 O O . THR A 1 226 ? 32.482 10.364 -10.337 1.00 22.03 ? 226 THR A O 1 ATOM 1700 C CB . THR A 1 226 ? 34.870 10.937 -8.701 1.00 20.82 ? 226 THR A CB 1 ATOM 1701 O OG1 . THR A 1 226 ? 34.575 12.326 -8.522 1.00 20.39 ? 226 THR A OG1 1 ATOM 1702 C CG2 . THR A 1 226 ? 36.271 10.750 -8.127 1.00 20.72 ? 226 THR A CG2 1 ATOM 1703 N N . ARG A 1 227 ? 33.357 12.066 -11.486 1.00 22.22 ? 227 ARG A N 1 ATOM 1704 C CA . ARG A 1 227 ? 32.062 12.667 -11.798 1.00 22.42 ? 227 ARG A CA 1 ATOM 1705 C C . ARG A 1 227 ? 31.253 11.852 -12.800 1.00 23.33 ? 227 ARG A C 1 ATOM 1706 O O . ARG A 1 227 ? 31.808 11.228 -13.713 1.00 23.47 ? 227 ARG A O 1 ATOM 1707 C CB . ARG A 1 227 ? 32.238 14.087 -12.320 1.00 22.41 ? 227 ARG A CB 1 ATOM 1708 C CG . ARG A 1 227 ? 32.963 15.017 -11.353 1.00 21.23 ? 227 ARG A CG 1 ATOM 1709 C CD . ARG A 1 227 ? 32.782 16.466 -11.697 1.00 20.08 ? 227 ARG A CD 1 ATOM 1710 N NE . ARG A 1 227 ? 31.409 16.911 -11.479 1.00 18.06 ? 227 ARG A NE 1 ATOM 1711 C CZ . ARG A 1 227 ? 30.912 17.266 -10.305 1.00 20.93 ? 227 ARG A CZ 1 ATOM 1712 N NH1 . ARG A 1 227 ? 31.656 17.214 -9.197 1.00 21.16 ? 227 ARG A NH1 1 ATOM 1713 N NH2 . ARG A 1 227 ? 29.654 17.659 -10.221 1.00 20.30 ? 227 ARG A NH2 1 ATOM 1714 N N . LEU A 1 228 ? 29.937 11.869 -12.608 1.00 23.94 ? 228 LEU A N 1 ATOM 1715 C CA . LEU A 1 228 ? 29.009 11.115 -13.451 1.00 24.71 ? 228 LEU A CA 1 ATOM 1716 C C . LEU A 1 228 ? 28.175 12.037 -14.355 1.00 24.43 ? 228 LEU A C 1 ATOM 1717 O O . LEU A 1 228 ? 27.445 11.554 -15.208 1.00 24.24 ? 228 LEU A O 1 ATOM 1718 C CB . LEU A 1 228 ? 28.084 10.278 -12.568 1.00 24.99 ? 228 LEU A CB 1 ATOM 1719 C CG . LEU A 1 228 ? 28.685 9.072 -11.841 1.00 25.70 ? 228 LEU A CG 1 ATOM 1720 C CD1 . LEU A 1 228 ? 30.008 9.369 -11.222 1.00 28.22 ? 228 LEU A CD1 1 ATOM 1721 C CD2 . LEU A 1 228 ? 27.727 8.592 -10.780 1.00 25.81 ? 228 LEU A CD2 1 ATOM 1722 N N . ASP A 1 229 ? 28.294 13.352 -14.149 1.00 24.02 ? 229 ASP A N 1 ATOM 1723 C CA . ASP A 1 229 ? 27.489 14.342 -14.863 1.00 24.06 ? 229 ASP A CA 1 ATOM 1724 C C . ASP A 1 229 ? 28.199 14.920 -16.090 1.00 24.03 ? 229 ASP A C 1 ATOM 1725 O O . ASP A 1 229 ? 27.678 15.824 -16.737 1.00 23.84 ? 229 ASP A O 1 ATOM 1726 C CB . ASP A 1 229 ? 27.041 15.470 -13.909 1.00 23.57 ? 229 ASP A CB 1 ATOM 1727 C CG . ASP A 1 229 ? 28.204 16.226 -13.274 1.00 23.54 ? 229 ASP A CG 1 ATOM 1728 O OD1 . ASP A 1 229 ? 29.389 15.883 -13.504 1.00 22.42 ? 229 ASP A OD1 1 ATOM 1729 O OD2 . ASP A 1 229 ? 28.005 17.186 -12.500 1.00 22.70 ? 229 ASP A OD2 1 ATOM 1730 N N . GLY A 1 230 ? 29.383 14.394 -16.400 1.00 24.29 ? 230 GLY A N 1 ATOM 1731 C CA . GLY A 1 230 ? 30.141 14.805 -17.578 1.00 24.56 ? 230 GLY A CA 1 ATOM 1732 C C . GLY A 1 230 ? 30.919 16.103 -17.456 1.00 24.52 ? 230 GLY A C 1 ATOM 1733 O O . GLY A 1 230 ? 31.646 16.470 -18.384 1.00 25.15 ? 230 GLY A O 1 ATOM 1734 N N . LYS A 1 231 ? 30.790 16.791 -16.323 1.00 24.09 ? 231 LYS A N 1 ATOM 1735 C CA . LYS A 1 231 ? 31.421 18.094 -16.141 1.00 23.77 ? 231 LYS A CA 1 ATOM 1736 C C . LYS A 1 231 ? 32.910 18.006 -15.862 1.00 23.14 ? 231 LYS A C 1 ATOM 1737 O O . LYS A 1 231 ? 33.374 17.115 -15.155 1.00 23.04 ? 231 LYS A O 1 ATOM 1738 C CB . LYS A 1 231 ? 30.755 18.867 -15.003 1.00 24.06 ? 231 LYS A CB 1 ATOM 1739 C CG . LYS A 1 231 ? 29.309 19.154 -15.252 1.00 25.30 ? 231 LYS A CG 1 ATOM 1740 C CD . LYS A 1 231 ? 28.728 19.997 -14.160 1.00 27.70 ? 231 LYS A CD 1 ATOM 1741 C CE . LYS A 1 231 ? 27.235 20.135 -14.341 1.00 29.25 ? 231 LYS A CE 1 ATOM 1742 N NZ . LYS A 1 231 ? 26.744 21.380 -13.681 1.00 31.54 ? 231 LYS A NZ 1 ATOM 1743 N N . ASN A 1 232 ? 33.642 18.923 -16.486 1.00 22.73 ? 232 ASN A N 1 ATOM 1744 C CA . ASN A 1 232 ? 34.995 19.259 -16.115 1.00 22.25 ? 232 ASN A CA 1 ATOM 1745 C C . ASN A 1 232 ? 34.895 20.587 -15.370 1.00 21.69 ? 232 ASN A C 1 ATOM 1746 O O . ASN A 1 232 ? 34.759 21.651 -15.990 1.00 21.97 ? 232 ASN A O 1 ATOM 1747 C CB . ASN A 1 232 ? 35.878 19.386 -17.365 1.00 22.33 ? 232 ASN A CB 1 ATOM 1748 C CG . ASN A 1 232 ? 37.331 19.707 -17.035 1.00 23.60 ? 232 ASN A CG 1 ATOM 1749 O OD1 . ASN A 1 232 ? 37.632 20.312 -16.008 1.00 21.71 ? 232 ASN A OD1 1 ATOM 1750 N ND2 . ASN A 1 232 ? 38.245 19.285 -17.910 1.00 25.50 ? 232 ASN A ND2 1 ATOM 1751 N N . LEU A 1 233 ? 34.939 20.526 -14.041 1.00 20.63 ? 233 LEU A N 1 ATOM 1752 C CA . LEU A 1 233 ? 34.764 21.726 -13.211 1.00 20.14 ? 233 LEU A CA 1 ATOM 1753 C C . LEU A 1 233 ? 35.950 22.676 -13.264 1.00 19.94 ? 233 LEU A C 1 ATOM 1754 O O . LEU A 1 233 ? 35.783 23.873 -13.065 1.00 19.65 ? 233 LEU A O 1 ATOM 1755 C CB . LEU A 1 233 ? 34.476 21.347 -11.754 1.00 19.62 ? 233 LEU A CB 1 ATOM 1756 C CG . LEU A 1 233 ? 33.161 20.599 -11.556 1.00 18.89 ? 233 LEU A CG 1 ATOM 1757 C CD1 . LEU A 1 233 ? 32.992 20.153 -10.126 1.00 17.50 ? 233 LEU A CD1 1 ATOM 1758 C CD2 . LEU A 1 233 ? 31.989 21.474 -11.984 1.00 19.57 ? 233 LEU A CD2 1 ATOM 1759 N N . VAL A 1 234 ? 37.139 22.145 -13.532 1.00 20.31 ? 234 VAL A N 1 ATOM 1760 C CA . VAL A 1 234 ? 38.320 22.975 -13.706 1.00 20.63 ? 234 VAL A CA 1 ATOM 1761 C C . VAL A 1 234 ? 38.130 23.838 -14.943 1.00 21.39 ? 234 VAL A C 1 ATOM 1762 O O . VAL A 1 234 ? 38.324 25.045 -14.905 1.00 20.53 ? 234 VAL A O 1 ATOM 1763 C CB . VAL A 1 234 ? 39.612 22.120 -13.813 1.00 20.79 ? 234 VAL A CB 1 ATOM 1764 C CG1 . VAL A 1 234 ? 40.791 22.958 -14.253 1.00 20.59 ? 234 VAL A CG1 1 ATOM 1765 C CG2 . VAL A 1 234 ? 39.908 21.450 -12.485 1.00 19.71 ? 234 VAL A CG2 1 ATOM 1766 N N . GLN A 1 235 ? 37.729 23.203 -16.033 1.00 22.46 ? 235 GLN A N 1 ATOM 1767 C CA . GLN A 1 235 ? 37.475 23.905 -17.278 1.00 23.95 ? 235 GLN A CA 1 ATOM 1768 C C . GLN A 1 235 ? 36.360 24.934 -17.120 1.00 23.71 ? 235 GLN A C 1 ATOM 1769 O O . GLN A 1 235 ? 36.484 26.050 -17.610 1.00 23.92 ? 235 GLN A O 1 ATOM 1770 C CB . GLN A 1 235 ? 37.127 22.901 -18.373 1.00 24.60 ? 235 GLN A CB 1 ATOM 1771 C CG . GLN A 1 235 ? 37.307 23.428 -19.764 1.00 28.18 ? 235 GLN A CG 1 ATOM 1772 C CD . GLN A 1 235 ? 37.023 22.372 -20.813 1.00 33.56 ? 235 GLN A CD 1 ATOM 1773 O OE1 . GLN A 1 235 ? 37.595 22.414 -21.915 1.00 37.66 ? 235 GLN A OE1 1 ATOM 1774 N NE2 . GLN A 1 235 ? 36.151 21.413 -20.478 1.00 34.87 ? 235 GLN A NE2 1 ATOM 1775 N N . GLU A 1 236 ? 35.283 24.568 -16.424 1.00 23.57 ? 236 GLU A N 1 ATOM 1776 C CA . GLU A 1 236 ? 34.186 25.504 -16.167 1.00 23.78 ? 236 GLU A CA 1 ATOM 1777 C C . GLU A 1 236 ? 34.659 26.694 -15.329 1.00 23.68 ? 236 GLU A C 1 ATOM 1778 O O . GLU A 1 236 ? 34.266 27.841 -15.576 1.00 22.75 ? 236 GLU A O 1 ATOM 1779 C CB . GLU A 1 236 ? 33.025 24.809 -15.456 1.00 23.55 ? 236 GLU A CB 1 ATOM 1780 C CG . GLU A 1 236 ? 32.237 23.830 -16.324 1.00 24.38 ? 236 GLU A CG 1 ATOM 1781 C CD . GLU A 1 236 ? 30.998 23.299 -15.625 1.00 24.55 ? 236 GLU A CD 1 ATOM 1782 O OE1 . GLU A 1 236 ? 30.579 23.902 -14.614 1.00 25.96 ? 236 GLU A OE1 1 ATOM 1783 O OE2 . GLU A 1 236 ? 30.445 22.270 -16.068 1.00 26.55 ? 236 GLU A OE2 1 ATOM 1784 N N . TRP A 1 237 ? 35.492 26.409 -14.332 1.00 23.62 ? 237 TRP A N 1 ATOM 1785 C CA . TRP A 1 237 ? 36.063 27.449 -13.476 1.00 24.09 ? 237 TRP A CA 1 ATOM 1786 C C . TRP A 1 237 ? 36.991 28.388 -14.265 1.00 24.74 ? 237 TRP A C 1 ATOM 1787 O O . TRP A 1 237 ? 36.871 29.609 -14.187 1.00 24.42 ? 237 TRP A O 1 ATOM 1788 C CB . TRP A 1 237 ? 36.833 26.797 -12.326 1.00 23.89 ? 237 TRP A CB 1 ATOM 1789 C CG . TRP A 1 237 ? 37.316 27.746 -11.294 1.00 23.09 ? 237 TRP A CG 1 ATOM 1790 C CD1 . TRP A 1 237 ? 36.587 28.277 -10.271 1.00 23.62 ? 237 TRP A CD1 1 ATOM 1791 C CD2 . TRP A 1 237 ? 38.637 28.272 -11.161 1.00 22.33 ? 237 TRP A CD2 1 ATOM 1792 N NE1 . TRP A 1 237 ? 37.373 29.110 -9.511 1.00 23.74 ? 237 TRP A NE1 1 ATOM 1793 C CE2 . TRP A 1 237 ? 38.637 29.127 -10.033 1.00 23.71 ? 237 TRP A CE2 1 ATOM 1794 C CE3 . TRP A 1 237 ? 39.826 28.112 -11.879 1.00 23.13 ? 237 TRP A CE3 1 ATOM 1795 C CZ2 . TRP A 1 237 ? 39.780 29.812 -9.604 1.00 23.85 ? 237 TRP A CZ2 1 ATOM 1796 C CZ3 . TRP A 1 237 ? 40.965 28.803 -11.454 1.00 23.98 ? 237 TRP A CZ3 1 ATOM 1797 C CH2 . TRP A 1 237 ? 40.928 29.637 -10.324 1.00 23.71 ? 237 TRP A CH2 1 ATOM 1798 N N . LEU A 1 238 ? 37.919 27.815 -15.022 1.00 25.82 ? 238 LEU A N 1 ATOM 1799 C CA . LEU A 1 238 ? 38.803 28.617 -15.873 1.00 27.28 ? 238 LEU A CA 1 ATOM 1800 C C . LEU A 1 238 ? 38.002 29.512 -16.833 1.00 28.87 ? 238 LEU A C 1 ATOM 1801 O O . LEU A 1 238 ? 38.326 30.688 -17.026 1.00 28.82 ? 238 LEU A O 1 ATOM 1802 C CB . LEU A 1 238 ? 39.734 27.713 -16.684 1.00 27.34 ? 238 LEU A CB 1 ATOM 1803 C CG . LEU A 1 238 ? 40.840 26.981 -15.917 1.00 26.67 ? 238 LEU A CG 1 ATOM 1804 C CD1 . LEU A 1 238 ? 41.524 25.971 -16.826 1.00 26.23 ? 238 LEU A CD1 1 ATOM 1805 C CD2 . LEU A 1 238 ? 41.851 27.966 -15.340 1.00 26.75 ? 238 LEU A CD2 1 ATOM 1806 N N . ALA A 1 239 ? 36.954 28.945 -17.420 1.00 30.67 ? 239 ALA A N 1 ATOM 1807 C CA . ALA A 1 239 ? 36.143 29.646 -18.416 1.00 32.28 ? 239 ALA A CA 1 ATOM 1808 C C . ALA A 1 239 ? 35.408 30.857 -17.850 1.00 33.73 ? 239 ALA A C 1 ATOM 1809 O O . ALA A 1 239 ? 35.111 31.803 -18.577 1.00 34.35 ? 239 ALA A O 1 ATOM 1810 C CB . ALA A 1 239 ? 35.139 28.687 -19.049 1.00 32.16 ? 239 ALA A CB 1 ATOM 1811 N N . LYS A 1 240 ? 35.103 30.848 -16.563 1.00 35.25 ? 240 LYS A N 1 ATOM 1812 C CA . LYS A 1 240 ? 34.367 31.976 -16.009 1.00 36.84 ? 240 LYS A CA 1 ATOM 1813 C C . LYS A 1 240 ? 35.257 32.990 -15.303 1.00 37.72 ? 240 LYS A C 1 ATOM 1814 O O . LYS A 1 240 ? 34.759 33.806 -14.537 1.00 38.56 ? 240 LYS A O 1 ATOM 1815 C CB . LYS A 1 240 ? 33.222 31.501 -15.112 1.00 37.03 ? 240 LYS A CB 1 ATOM 1816 C CG . LYS A 1 240 ? 33.599 30.683 -13.892 1.00 37.94 ? 240 LYS A CG 1 ATOM 1817 C CD . LYS A 1 240 ? 32.394 29.830 -13.526 1.00 39.06 ? 240 LYS A CD 1 ATOM 1818 C CE . LYS A 1 240 ? 32.469 29.263 -12.142 1.00 39.10 ? 240 LYS A CE 1 ATOM 1819 N NZ . LYS A 1 240 ? 31.261 28.416 -11.930 1.00 40.71 ? 240 LYS A NZ 1 ATOM 1820 N N . ARG A 1 241 ? 36.563 32.955 -15.577 1.00 38.66 ? 241 ARG A N 1 ATOM 1821 C CA . ARG A 1 241 ? 37.510 33.886 -14.959 1.00 39.20 ? 241 ARG A CA 1 ATOM 1822 C C . ARG A 1 241 ? 38.660 34.192 -15.895 1.00 39.09 ? 241 ARG A C 1 ATOM 1823 O O . ARG A 1 241 ? 39.356 33.281 -16.340 1.00 39.50 ? 241 ARG A O 1 ATOM 1824 C CB . ARG A 1 241 ? 38.060 33.284 -13.675 1.00 39.63 ? 241 ARG A CB 1 ATOM 1825 C CG . ARG A 1 241 ? 37.015 33.078 -12.628 1.00 40.54 ? 241 ARG A CG 1 ATOM 1826 C CD . ARG A 1 241 ? 37.413 32.192 -11.500 1.00 41.59 ? 241 ARG A CD 1 ATOM 1827 N NE . ARG A 1 241 ? 36.268 31.444 -10.974 1.00 43.24 ? 241 ARG A NE 1 ATOM 1828 C CZ . ARG A 1 241 ? 35.191 31.978 -10.381 1.00 43.82 ? 241 ARG A CZ 1 ATOM 1829 N NH1 . ARG A 1 241 ? 34.228 31.182 -9.921 1.00 43.69 ? 241 ARG A NH1 1 ATOM 1830 N NH2 . ARG A 1 241 ? 35.049 33.290 -10.256 1.00 45.64 ? 241 ARG A NH2 1 ATOM 1831 N N . GLN A 1 242 ? 38.866 35.468 -16.205 1.00 38.91 ? 242 GLN A N 1 ATOM 1832 C CA . GLN A 1 242 ? 40.038 35.844 -16.984 1.00 38.58 ? 242 GLN A CA 1 ATOM 1833 C C . GLN A 1 242 ? 41.202 36.071 -16.019 1.00 37.12 ? 242 GLN A C 1 ATOM 1834 O O . GLN A 1 242 ? 41.021 36.606 -14.919 1.00 37.75 ? 242 GLN A O 1 ATOM 1835 C CB . GLN A 1 242 ? 39.794 37.078 -17.852 1.00 39.11 ? 242 GLN A CB 1 ATOM 1836 C CG . GLN A 1 242 ? 40.694 37.101 -19.085 1.00 41.18 ? 242 GLN A CG 1 ATOM 1837 C CD . GLN A 1 242 ? 41.149 38.498 -19.460 1.00 44.16 ? 242 GLN A CD 1 ATOM 1838 O OE1 . GLN A 1 242 ? 42.353 38.753 -19.571 1.00 46.74 ? 242 GLN A OE1 1 ATOM 1839 N NE2 . GLN A 1 242 ? 40.196 39.408 -19.649 1.00 45.54 ? 242 GLN A NE2 1 ATOM 1840 N N . GLY A 1 243 ? 42.390 35.652 -16.439 1.00 35.23 ? 243 GLY A N 1 ATOM 1841 C CA . GLY A 1 243 ? 43.548 35.593 -15.559 1.00 33.66 ? 243 GLY A CA 1 ATOM 1842 C C . GLY A 1 243 ? 43.626 34.274 -14.803 1.00 32.19 ? 243 GLY A C 1 ATOM 1843 O O . GLY A 1 243 ? 44.512 34.092 -13.957 1.00 32.16 ? 243 GLY A O 1 ATOM 1844 N N . ALA A 1 244 ? 42.725 33.343 -15.120 1.00 30.25 ? 244 ALA A N 1 ATOM 1845 C CA . ALA A 1 244 ? 42.615 32.094 -14.380 1.00 28.81 ? 244 ALA A CA 1 ATOM 1846 C C . ALA A 1 244 ? 43.648 31.081 -14.831 1.00 27.80 ? 244 ALA A C 1 ATOM 1847 O O . ALA A 1 244 ? 43.912 30.915 -16.031 1.00 27.38 ? 244 ALA A O 1 ATOM 1848 C CB . ALA A 1 244 ? 41.215 31.517 -14.509 1.00 29.04 ? 244 ALA A CB 1 ATOM 1849 N N . ARG A 1 245 ? 44.255 30.403 -13.866 1.00 26.13 ? 245 ARG A N 1 ATOM 1850 C CA . ARG A 1 245 ? 45.189 29.341 -14.190 1.00 25.49 ? 245 ARG A CA 1 ATOM 1851 C C . ARG A 1 245 ? 44.999 28.148 -13.283 1.00 23.98 ? 245 ARG A C 1 ATOM 1852 O O . ARG A 1 245 ? 44.734 28.293 -12.088 1.00 23.38 ? 245 ARG A O 1 ATOM 1853 C CB . ARG A 1 245 ? 46.637 29.822 -14.119 1.00 25.84 ? 245 ARG A CB 1 ATOM 1854 C CG . ARG A 1 245 ? 47.577 28.815 -14.783 1.00 29.12 ? 245 ARG A CG 1 ATOM 1855 C CD . ARG A 1 245 ? 48.830 29.379 -15.422 1.00 32.18 ? 245 ARG A CD 1 ATOM 1856 N NE . ARG A 1 245 ? 49.956 28.553 -15.003 1.00 34.79 ? 245 ARG A NE 1 ATOM 1857 C CZ . ARG A 1 245 ? 51.226 28.935 -14.961 1.00 35.88 ? 245 ARG A CZ 1 ATOM 1858 N NH1 . ARG A 1 245 ? 52.136 28.080 -14.509 1.00 35.58 ? 245 ARG A NH1 1 ATOM 1859 N NH2 . ARG A 1 245 ? 51.596 30.152 -15.351 1.00 36.81 ? 245 ARG A NH2 1 ATOM 1860 N N . TYR A 1 246 ? 45.138 26.969 -13.872 1.00 22.15 ? 246 TYR A N 1 ATOM 1861 C CA . TYR A 1 246 ? 45.064 25.719 -13.148 1.00 21.12 ? 246 TYR A CA 1 ATOM 1862 C C . TYR A 1 246 ? 46.407 25.024 -13.204 1.00 20.54 ? 246 TYR A C 1 ATOM 1863 O O . TYR A 1 246 ? 47.003 24.902 -14.276 1.00 19.83 ? 246 TYR A O 1 ATOM 1864 C CB . TYR A 1 246 ? 44.002 24.826 -13.771 1.00 21.00 ? 246 TYR A CB 1 ATOM 1865 C CG . TYR A 1 246 ? 43.999 23.416 -13.235 1.00 20.30 ? 246 TYR A CG 1 ATOM 1866 C CD1 . TYR A 1 246 ? 43.598 23.145 -11.930 1.00 20.82 ? 246 TYR A CD1 1 ATOM 1867 C CD2 . TYR A 1 246 ? 44.374 22.356 -14.036 1.00 20.38 ? 246 TYR A CD2 1 ATOM 1868 C CE1 . TYR A 1 246 ? 43.576 21.845 -11.446 1.00 19.83 ? 246 TYR A CE1 1 ATOM 1869 C CE2 . TYR A 1 246 ? 44.368 21.067 -13.560 1.00 21.27 ? 246 TYR A CE2 1 ATOM 1870 C CZ . TYR A 1 246 ? 43.949 20.814 -12.269 1.00 19.92 ? 246 TYR A CZ 1 ATOM 1871 O OH . TYR A 1 246 ? 43.949 19.523 -11.808 1.00 19.83 ? 246 TYR A OH 1 ATOM 1872 N N . VAL A 1 247 ? 46.886 24.582 -12.046 1.00 19.50 ? 247 VAL A N 1 ATOM 1873 C CA . VAL A 1 247 ? 48.135 23.838 -11.957 1.00 19.07 ? 247 VAL A CA 1 ATOM 1874 C C . VAL A 1 247 ? 47.902 22.608 -11.101 1.00 19.31 ? 247 VAL A C 1 ATOM 1875 O O . VAL A 1 247 ? 46.995 22.584 -10.271 1.00 18.00 ? 247 VAL A O 1 ATOM 1876 C CB . VAL A 1 247 ? 49.262 24.689 -11.350 1.00 19.05 ? 247 VAL A CB 1 ATOM 1877 C CG1 . VAL A 1 247 ? 49.389 26.002 -12.115 1.00 19.51 ? 247 VAL A CG1 1 ATOM 1878 C CG2 . VAL A 1 247 ? 49.020 24.936 -9.864 1.00 17.78 ? 247 VAL A CG2 1 ATOM 1879 N N . TRP A 1 248 ? 48.702 21.575 -11.343 1.00 19.34 ? 248 TRP A N 1 ATOM 1880 C CA . TRP A 1 248 ? 48.633 20.360 -10.548 1.00 20.14 ? 248 TRP A CA 1 ATOM 1881 C C . TRP A 1 248 ? 49.989 19.944 -9.999 1.00 19.59 ? 248 TRP A C 1 ATOM 1882 O O . TRP A 1 248 ? 50.107 18.899 -9.357 1.00 19.33 ? 248 TRP A O 1 ATOM 1883 C CB . TRP A 1 248 ? 47.990 19.221 -11.346 1.00 20.62 ? 248 TRP A CB 1 ATOM 1884 C CG . TRP A 1 248 ? 48.683 18.885 -12.630 1.00 21.03 ? 248 TRP A CG 1 ATOM 1885 C CD1 . TRP A 1 248 ? 48.390 19.370 -13.872 1.00 22.15 ? 248 TRP A CD1 1 ATOM 1886 C CD2 . TRP A 1 248 ? 49.773 17.970 -12.802 1.00 21.18 ? 248 TRP A CD2 1 ATOM 1887 N NE1 . TRP A 1 248 ? 49.236 18.816 -14.805 1.00 21.98 ? 248 TRP A NE1 1 ATOM 1888 C CE2 . TRP A 1 248 ? 50.098 17.956 -14.172 1.00 22.74 ? 248 TRP A CE2 1 ATOM 1889 C CE3 . TRP A 1 248 ? 50.512 17.162 -11.935 1.00 22.11 ? 248 TRP A CE3 1 ATOM 1890 C CZ2 . TRP A 1 248 ? 51.127 17.166 -14.692 1.00 22.38 ? 248 TRP A CZ2 1 ATOM 1891 C CZ3 . TRP A 1 248 ? 51.536 16.375 -12.452 1.00 22.26 ? 248 TRP A CZ3 1 ATOM 1892 C CH2 . TRP A 1 248 ? 51.828 16.384 -13.816 1.00 22.03 ? 248 TRP A CH2 1 ATOM 1893 N N . ASN A 1 249 ? 51.013 20.762 -10.232 1.00 19.73 ? 249 ASN A N 1 ATOM 1894 C CA . ASN A 1 249 ? 52.321 20.484 -9.677 1.00 19.50 ? 249 ASN A CA 1 ATOM 1895 C C . ASN A 1 249 ? 53.060 21.745 -9.239 1.00 19.46 ? 249 ASN A C 1 ATOM 1896 O O . ASN A 1 249 ? 52.667 22.871 -9.563 1.00 19.74 ? 249 ASN A O 1 ATOM 1897 C CB . ASN A 1 249 ? 53.178 19.607 -10.623 1.00 19.51 ? 249 ASN A CB 1 ATOM 1898 C CG . ASN A 1 249 ? 53.505 20.275 -11.951 1.00 20.20 ? 249 ASN A CG 1 ATOM 1899 O OD1 . ASN A 1 249 ? 53.879 21.453 -11.996 1.00 21.70 ? 249 ASN A OD1 1 ATOM 1900 N ND2 . ASN A 1 249 ? 53.369 19.501 -13.051 1.00 21.19 ? 249 ASN A ND2 1 ATOM 1901 N N . ARG A 1 250 ? 54.122 21.515 -8.486 1.00 18.97 ? 250 ARG A N 1 ATOM 1902 C CA . ARG A 1 250 ? 54.843 22.555 -7.776 1.00 19.28 ? 250 ARG A CA 1 ATOM 1903 C C . ARG A 1 250 ? 55.500 23.575 -8.693 1.00 20.25 ? 250 ARG A C 1 ATOM 1904 O O . ARG A 1 250 ? 55.441 24.779 -8.427 1.00 20.27 ? 250 ARG A O 1 ATOM 1905 C CB . ARG A 1 250 ? 55.898 21.900 -6.887 1.00 18.87 ? 250 ARG A CB 1 ATOM 1906 C CG . ARG A 1 250 ? 56.676 22.844 -6.013 1.00 18.38 ? 250 ARG A CG 1 ATOM 1907 C CD . ARG A 1 250 ? 57.574 22.136 -5.038 1.00 18.74 ? 250 ARG A CD 1 ATOM 1908 N NE . ARG A 1 250 ? 58.390 23.064 -4.273 1.00 18.34 ? 250 ARG A NE 1 ATOM 1909 C CZ . ARG A 1 250 ? 59.600 23.486 -4.622 1.00 19.18 ? 250 ARG A CZ 1 ATOM 1910 N NH1 . ARG A 1 250 ? 60.159 23.112 -5.773 1.00 20.25 ? 250 ARG A NH1 1 ATOM 1911 N NH2 . ARG A 1 250 ? 60.246 24.324 -3.829 1.00 19.84 ? 250 ARG A NH2 1 ATOM 1912 N N . THR A 1 251 ? 56.139 23.098 -9.755 1.00 21.06 ? 251 THR A N 1 ATOM 1913 C CA . THR A 1 251 ? 56.841 23.994 -10.658 1.00 22.04 ? 251 THR A CA 1 ATOM 1914 C C . THR A 1 251 ? 55.853 24.926 -11.362 1.00 21.52 ? 251 THR A C 1 ATOM 1915 O O . THR A 1 251 ? 56.126 26.107 -11.516 1.00 21.29 ? 251 THR A O 1 ATOM 1916 C CB . THR A 1 251 ? 57.720 23.209 -11.666 1.00 22.53 ? 251 THR A CB 1 ATOM 1917 O OG1 . THR A 1 251 ? 57.073 21.996 -12.057 1.00 27.04 ? 251 THR A OG1 1 ATOM 1918 C CG2 . THR A 1 251 ? 58.969 22.697 -11.015 1.00 22.42 ? 251 THR A CG2 1 ATOM 1919 N N . GLU A 1 252 ? 54.686 24.407 -11.726 1.00 21.48 ? 252 GLU A N 1 ATOM 1920 C CA . GLU A 1 252 ? 53.655 25.235 -12.340 1.00 21.53 ? 252 GLU A CA 1 ATOM 1921 C C . GLU A 1 252 ? 53.073 26.233 -11.348 1.00 21.03 ? 252 GLU A C 1 ATOM 1922 O O . GLU A 1 252 ? 52.769 27.371 -11.709 1.00 20.06 ? 252 GLU A O 1 ATOM 1923 C CB . GLU A 1 252 ? 52.566 24.377 -12.981 1.00 22.26 ? 252 GLU A CB 1 ATOM 1924 C CG . GLU A 1 252 ? 53.049 23.674 -14.238 1.00 24.99 ? 252 GLU A CG 1 ATOM 1925 C CD . GLU A 1 252 ? 53.519 24.653 -15.289 1.00 28.97 ? 252 GLU A CD 1 ATOM 1926 O OE1 . GLU A 1 252 ? 52.667 25.419 -15.797 1.00 33.24 ? 252 GLU A OE1 1 ATOM 1927 O OE2 . GLU A 1 252 ? 54.737 24.664 -15.594 1.00 31.77 ? 252 GLU A OE2 1 ATOM 1928 N N . LEU A 1 253 ? 52.942 25.812 -10.091 1.00 21.15 ? 253 LEU A N 1 ATOM 1929 C CA . LEU A 1 253 ? 52.485 26.704 -9.022 1.00 20.73 ? 253 LEU A CA 1 ATOM 1930 C C . LEU A 1 253 ? 53.437 27.879 -8.879 1.00 21.41 ? 253 LEU A C 1 ATOM 1931 O O . LEU A 1 253 ? 53.018 29.038 -8.822 1.00 20.91 ? 253 LEU A O 1 ATOM 1932 C CB . LEU A 1 253 ? 52.416 25.949 -7.689 1.00 20.47 ? 253 LEU A CB 1 ATOM 1933 C CG . LEU A 1 253 ? 52.068 26.826 -6.484 1.00 19.88 ? 253 LEU A CG 1 ATOM 1934 C CD1 . LEU A 1 253 ? 50.653 27.403 -6.679 1.00 19.57 ? 253 LEU A CD1 1 ATOM 1935 C CD2 . LEU A 1 253 ? 52.207 26.044 -5.180 1.00 20.06 ? 253 LEU A CD2 1 ATOM 1936 N N . MET A 1 254 ? 54.729 27.561 -8.815 1.00 22.69 ? 254 MET A N 1 ATOM 1937 C CA . MET A 1 254 ? 55.781 28.572 -8.730 1.00 24.37 ? 254 MET A CA 1 ATOM 1938 C C . MET A 1 254 ? 55.664 29.612 -9.832 1.00 24.38 ? 254 MET A C 1 ATOM 1939 O O . MET A 1 254 ? 55.632 30.803 -9.554 1.00 24.61 ? 254 MET A O 1 ATOM 1940 C CB . MET A 1 254 ? 57.160 27.923 -8.840 1.00 24.40 ? 254 MET A CB 1 ATOM 1941 C CG . MET A 1 254 ? 57.509 26.952 -7.726 1.00 25.66 ? 254 MET A CG 1 ATOM 1942 S SD . MET A 1 254 ? 59.248 26.449 -7.691 1.00 28.70 ? 254 MET A SD 1 ATOM 1943 C CE . MET A 1 254 ? 59.712 26.639 -9.402 1.00 29.03 ? 254 MET A CE 1 ATOM 1944 N N . GLN A 1 255 ? 55.619 29.153 -11.080 1.00 25.50 ? 255 GLN A N 1 ATOM 1945 C CA . GLN A 1 255 ? 55.503 30.048 -12.240 1.00 25.84 ? 255 GLN A CA 1 ATOM 1946 C C . GLN A 1 255 ? 54.253 30.936 -12.119 1.00 25.10 ? 255 GLN A C 1 ATOM 1947 O O . GLN A 1 255 ? 54.326 32.150 -12.278 1.00 25.62 ? 255 GLN A O 1 ATOM 1948 C CB . GLN A 1 255 ? 55.480 29.243 -13.555 1.00 25.97 ? 255 GLN A CB 1 ATOM 1949 C CG . GLN A 1 255 ? 55.444 30.107 -14.838 1.00 27.00 ? 255 GLN A CG 1 ATOM 1950 C CD . GLN A 1 255 ? 55.338 29.294 -16.144 1.00 28.31 ? 255 GLN A CD 1 ATOM 1951 O OE1 . GLN A 1 255 ? 54.291 28.688 -16.431 1.00 31.87 ? 255 GLN A OE1 1 ATOM 1952 N NE2 . GLN A 1 255 ? 56.410 29.311 -16.947 1.00 31.17 ? 255 GLN A NE2 1 ATOM 1953 N N . ALA A 1 256 ? 53.116 30.326 -11.821 1.00 24.62 ? 256 ALA A N 1 ATOM 1954 C CA . ALA A 1 256 ? 51.856 31.057 -11.677 1.00 23.47 ? 256 ALA A CA 1 ATOM 1955 C C . ALA A 1 256 ? 51.902 32.118 -10.577 1.00 22.94 ? 256 ALA A C 1 ATOM 1956 O O . ALA A 1 256 ? 51.415 33.239 -10.773 1.00 22.61 ? 256 ALA A O 1 ATOM 1957 C CB . ALA A 1 256 ? 50.722 30.081 -11.409 1.00 23.94 ? 256 ALA A CB 1 ATOM 1958 N N . SER A 1 257 ? 52.482 31.771 -9.425 1.00 22.18 ? 257 SER A N 1 ATOM 1959 C CA . SER A 1 257 ? 52.481 32.669 -8.263 1.00 21.72 ? 257 SER A CA 1 ATOM 1960 C C . SER A 1 257 ? 53.301 33.942 -8.492 1.00 22.41 ? 257 SER A C 1 ATOM 1961 O O . SER A 1 257 ? 53.072 34.935 -7.827 1.00 21.69 ? 257 SER A O 1 ATOM 1962 C CB . SER A 1 257 ? 52.990 31.944 -7.015 1.00 21.86 ? 257 SER A CB 1 ATOM 1963 O OG . SER A 1 257 ? 54.368 31.648 -7.123 1.00 19.22 ? 257 SER A OG 1 ATOM 1964 N N . LEU A 1 258 ? 54.227 33.897 -9.455 1.00 23.37 ? 258 LEU A N 1 ATOM 1965 C CA . LEU A 1 258 ? 55.052 35.048 -9.815 1.00 24.74 ? 258 LEU A CA 1 ATOM 1966 C C . LEU A 1 258 ? 54.574 35.726 -11.097 1.00 25.79 ? 258 LEU A C 1 ATOM 1967 O O . LEU A 1 258 ? 55.131 36.752 -11.501 1.00 26.37 ? 258 LEU A O 1 ATOM 1968 C CB . LEU A 1 258 ? 56.507 34.600 -10.002 1.00 24.64 ? 258 LEU A CB 1 ATOM 1969 C CG . LEU A 1 258 ? 57.214 34.119 -8.741 1.00 24.42 ? 258 LEU A CG 1 ATOM 1970 C CD1 . LEU A 1 258 ? 58.556 33.507 -9.089 1.00 24.54 ? 258 LEU A CD1 1 ATOM 1971 C CD2 . LEU A 1 258 ? 57.397 35.267 -7.768 1.00 25.37 ? 258 LEU A CD2 1 ATOM 1972 N N . ASP A 1 259 ? 53.546 35.158 -11.724 1.00 26.82 ? 259 ASP A N 1 ATOM 1973 C CA . ASP A 1 259 ? 53.067 35.609 -13.018 1.00 27.60 ? 259 ASP A CA 1 ATOM 1974 C C . ASP A 1 259 ? 52.034 36.681 -12.752 1.00 28.61 ? 259 ASP A C 1 ATOM 1975 O O . ASP A 1 259 ? 50.940 36.381 -12.273 1.00 27.93 ? 259 ASP A O 1 ATOM 1976 C CB . ASP A 1 259 ? 52.447 34.431 -13.790 1.00 27.54 ? 259 ASP A CB 1 ATOM 1977 C CG . ASP A 1 259 ? 52.035 34.790 -15.224 1.00 27.74 ? 259 ASP A CG 1 ATOM 1978 O OD1 . ASP A 1 259 ? 51.875 33.849 -16.051 1.00 24.87 ? 259 ASP A OD1 1 ATOM 1979 O OD2 . ASP A 1 259 ? 51.836 35.961 -15.617 1.00 25.64 ? 259 ASP A OD2 1 ATOM 1980 N N . PRO A 1 260 ? 52.343 37.929 -13.099 1.00 30.19 ? 260 PRO A N 1 ATOM 1981 C CA . PRO A 1 260 ? 51.383 38.991 -12.894 1.00 30.70 ? 260 PRO A CA 1 ATOM 1982 C C . PRO A 1 260 ? 50.333 38.652 -13.936 1.00 30.79 ? 260 PRO A C 1 ATOM 1983 O O . PRO A 1 260 ? 50.658 37.955 -14.883 1.00 32.20 ? 260 PRO A O 1 ATOM 1984 C CB . PRO A 1 260 ? 52.180 40.259 -13.225 1.00 31.02 ? 260 PRO A CB 1 ATOM 1985 C CG . PRO A 1 260 ? 53.223 39.824 -14.186 1.00 30.98 ? 260 PRO A CG 1 ATOM 1986 C CD . PRO A 1 260 ? 53.525 38.390 -13.852 1.00 30.65 ? 260 PRO A CD 1 ATOM 1987 N N . SER A 1 261 ? 49.085 39.029 -13.778 1.00 30.80 ? 261 SER A N 1 ATOM 1988 C CA . SER A 1 261 ? 48.089 38.610 -14.787 1.00 30.41 ? 261 SER A CA 1 ATOM 1989 C C . SER A 1 261 ? 47.554 37.181 -14.594 1.00 29.43 ? 261 SER A C 1 ATOM 1990 O O . SER A 1 261 ? 46.588 36.804 -15.254 1.00 28.96 ? 261 SER A O 1 ATOM 1991 C CB . SER A 1 261 ? 48.647 38.710 -16.211 1.00 30.74 ? 261 SER A CB 1 ATOM 1992 O OG . SER A 1 261 ? 49.242 37.475 -16.612 1.00 31.20 ? 261 SER A OG 1 ATOM 1993 N N . VAL A 1 262 ? 48.191 36.369 -13.747 1.00 27.99 ? 262 VAL A N 1 ATOM 1994 C CA . VAL A 1 262 ? 47.469 35.252 -13.143 1.00 27.40 ? 262 VAL A CA 1 ATOM 1995 C C . VAL A 1 262 ? 46.698 35.891 -11.993 1.00 26.77 ? 262 VAL A C 1 ATOM 1996 O O . VAL A 1 262 ? 47.301 36.300 -11.004 1.00 27.23 ? 262 VAL A O 1 ATOM 1997 C CB . VAL A 1 262 ? 48.389 34.125 -12.625 1.00 27.20 ? 262 VAL A CB 1 ATOM 1998 C CG1 . VAL A 1 262 ? 47.603 33.120 -11.794 1.00 26.96 ? 262 VAL A CG1 1 ATOM 1999 C CG2 . VAL A 1 262 ? 49.062 33.418 -13.778 1.00 27.42 ? 262 VAL A CG2 1 ATOM 2000 N N . THR A 1 263 ? 45.383 36.016 -12.139 1.00 25.62 ? 263 THR A N 1 ATOM 2001 C CA . THR A 1 263 ? 44.557 36.646 -11.107 1.00 25.14 ? 263 THR A CA 1 ATOM 2002 C C . THR A 1 263 ? 43.774 35.635 -10.287 1.00 23.86 ? 263 THR A C 1 ATOM 2003 O O . THR A 1 263 ? 43.397 35.922 -9.146 1.00 23.83 ? 263 THR A O 1 ATOM 2004 C CB . THR A 1 263 ? 43.571 37.629 -11.742 1.00 25.02 ? 263 THR A CB 1 ATOM 2005 O OG1 . THR A 1 263 ? 42.605 36.919 -12.524 1.00 26.73 ? 263 THR A OG1 1 ATOM 2006 C CG2 . THR A 1 263 ? 44.276 38.524 -12.741 1.00 27.20 ? 263 THR A CG2 1 ATOM 2007 N N . HIS A 1 264 ? 43.507 34.480 -10.896 1.00 22.42 ? 264 HIS A N 1 ATOM 2008 C CA . HIS A 1 264 ? 42.824 33.371 -10.251 1.00 21.19 ? 264 HIS A CA 1 ATOM 2009 C C . HIS A 1 264 ? 43.660 32.123 -10.393 1.00 19.99 ? 264 HIS A C 1 ATOM 2010 O O . HIS A 1 264 ? 44.070 31.779 -11.485 1.00 19.07 ? 264 HIS A O 1 ATOM 2011 C CB . HIS A 1 264 ? 41.438 33.185 -10.876 1.00 21.19 ? 264 HIS A CB 1 ATOM 2012 C CG . HIS A 1 264 ? 40.483 34.248 -10.467 1.00 21.85 ? 264 HIS A CG 1 ATOM 2013 N ND1 . HIS A 1 264 ? 39.498 34.046 -9.526 1.00 22.41 ? 264 HIS A ND1 1 ATOM 2014 C CD2 . HIS A 1 264 ? 40.418 35.554 -10.809 1.00 21.53 ? 264 HIS A CD2 1 ATOM 2015 C CE1 . HIS A 1 264 ? 38.852 35.177 -9.324 1.00 21.26 ? 264 HIS A CE1 1 ATOM 2016 N NE2 . HIS A 1 264 ? 39.387 36.109 -10.092 1.00 23.27 ? 264 HIS A NE2 1 ATOM 2017 N N . LEU A 1 265 ? 43.931 31.452 -9.282 1.00 19.53 ? 265 LEU A N 1 ATOM 2018 C CA . LEU A 1 265 ? 44.824 30.307 -9.302 1.00 19.15 ? 265 LEU A CA 1 ATOM 2019 C C . LEU A 1 265 ? 44.214 29.117 -8.586 1.00 19.05 ? 265 LEU A C 1 ATOM 2020 O O . LEU A 1 265 ? 43.901 29.199 -7.386 1.00 18.56 ? 265 LEU A O 1 ATOM 2021 C CB . LEU A 1 265 ? 46.145 30.678 -8.663 1.00 19.23 ? 265 LEU A CB 1 ATOM 2022 C CG . LEU A 1 265 ? 47.196 29.577 -8.555 1.00 19.56 ? 265 LEU A CG 1 ATOM 2023 C CD1 . LEU A 1 265 ? 47.575 29.031 -9.925 1.00 19.29 ? 265 LEU A CD1 1 ATOM 2024 C CD2 . LEU A 1 265 ? 48.410 30.150 -7.815 1.00 19.89 ? 265 LEU A CD2 1 ATOM 2025 N N . MET A 1 266 ? 44.045 28.021 -9.322 1.00 17.87 ? 266 MET A N 1 ATOM 2026 C CA . MET A 1 266 ? 43.568 26.769 -8.747 1.00 18.10 ? 266 MET A CA 1 ATOM 2027 C C . MET A 1 266 ? 44.670 25.738 -8.872 1.00 17.60 ? 266 MET A C 1 ATOM 2028 O O . MET A 1 266 ? 45.066 25.372 -9.977 1.00 17.02 ? 266 MET A O 1 ATOM 2029 C CB . MET A 1 266 ? 42.302 26.270 -9.451 1.00 18.13 ? 266 MET A CB 1 ATOM 2030 C CG . MET A 1 266 ? 41.808 24.922 -8.897 1.00 18.50 ? 266 MET A CG 1 ATOM 2031 S SD . MET A 1 266 ? 40.373 24.252 -9.736 1.00 19.53 ? 266 MET A SD 1 ATOM 2032 C CE . MET A 1 266 ? 39.101 25.306 -9.095 1.00 21.06 ? 266 MET A CE 1 ATOM 2033 N N . GLY A 1 267 ? 45.185 25.288 -7.733 1.00 17.59 ? 267 GLY A N 1 ATOM 2034 C CA . GLY A 1 267 ? 46.274 24.314 -7.709 1.00 17.32 ? 267 GLY A CA 1 ATOM 2035 C C . GLY A 1 267 ? 45.801 23.086 -6.972 1.00 17.17 ? 267 GLY A C 1 ATOM 2036 O O . GLY A 1 267 ? 45.630 23.131 -5.748 1.00 17.81 ? 267 GLY A O 1 ATOM 2037 N N . LEU A 1 268 ? 45.556 21.999 -7.698 1.00 16.90 ? 268 LEU A N 1 ATOM 2038 C CA . LEU A 1 268 ? 45.104 20.769 -7.070 1.00 16.58 ? 268 LEU A CA 1 ATOM 2039 C C . LEU A 1 268 ? 46.207 19.749 -7.278 1.00 17.14 ? 268 LEU A C 1 ATOM 2040 O O . LEU A 1 268 ? 46.470 19.329 -8.409 1.00 17.44 ? 268 LEU A O 1 ATOM 2041 C CB . LEU A 1 268 ? 43.767 20.315 -7.645 1.00 16.96 ? 268 LEU A CB 1 ATOM 2042 C CG . LEU A 1 268 ? 42.652 21.375 -7.564 1.00 16.31 ? 268 LEU A CG 1 ATOM 2043 C CD1 . LEU A 1 268 ? 41.346 20.803 -8.080 1.00 15.16 ? 268 LEU A CD1 1 ATOM 2044 C CD2 . LEU A 1 268 ? 42.462 21.922 -6.132 1.00 16.69 ? 268 LEU A CD2 1 ATOM 2045 N N . PHE A 1 269 ? 46.861 19.373 -6.182 1.00 16.76 ? 269 PHE A N 1 ATOM 2046 C CA . PHE A 1 269 ? 48.178 18.744 -6.239 1.00 16.58 ? 269 PHE A CA 1 ATOM 2047 C C . PHE A 1 269 ? 48.165 17.243 -6.014 1.00 16.82 ? 269 PHE A C 1 ATOM 2048 O O . PHE A 1 269 ? 49.165 16.581 -6.263 1.00 16.25 ? 269 PHE A O 1 ATOM 2049 C CB . PHE A 1 269 ? 49.129 19.446 -5.261 1.00 16.52 ? 269 PHE A CB 1 ATOM 2050 C CG . PHE A 1 269 ? 49.315 20.890 -5.577 1.00 15.73 ? 269 PHE A CG 1 ATOM 2051 C CD1 . PHE A 1 269 ? 48.721 21.869 -4.799 1.00 15.25 ? 269 PHE A CD1 1 ATOM 2052 C CD2 . PHE A 1 269 ? 50.035 21.271 -6.707 1.00 14.94 ? 269 PHE A CD2 1 ATOM 2053 C CE1 . PHE A 1 269 ? 48.844 23.204 -5.135 1.00 13.91 ? 269 PHE A CE1 1 ATOM 2054 C CE2 . PHE A 1 269 ? 50.169 22.594 -7.034 1.00 16.40 ? 269 PHE A CE2 1 ATOM 2055 C CZ . PHE A 1 269 ? 49.581 23.568 -6.248 1.00 15.66 ? 269 PHE A CZ 1 ATOM 2056 N N . GLU A 1 270 ? 47.039 16.707 -5.553 1.00 17.01 ? 270 GLU A N 1 ATOM 2057 C CA . GLU A 1 270 ? 46.849 15.267 -5.498 1.00 17.31 ? 270 GLU A CA 1 ATOM 2058 C C . GLU A 1 270 ? 45.418 14.992 -5.899 1.00 17.43 ? 270 GLU A C 1 ATOM 2059 O O . GLU A 1 270 ? 44.580 15.916 -5.877 1.00 16.64 ? 270 GLU A O 1 ATOM 2060 C CB . GLU A 1 270 ? 47.108 14.730 -4.092 1.00 17.52 ? 270 GLU A CB 1 ATOM 2061 C CG . GLU A 1 270 ? 48.565 14.673 -3.680 1.00 19.15 ? 270 GLU A CG 1 ATOM 2062 C CD . GLU A 1 270 ? 49.410 13.699 -4.491 1.00 21.43 ? 270 GLU A CD 1 ATOM 2063 O OE1 . GLU A 1 270 ? 48.977 12.557 -4.740 1.00 23.01 ? 270 GLU A OE1 1 ATOM 2064 O OE2 . GLU A 1 270 ? 50.548 14.066 -4.834 1.00 22.18 ? 270 GLU A OE2 1 ATOM 2065 N N . PRO A 1 271 ? 45.131 13.734 -6.245 1.00 17.47 ? 271 PRO A N 1 ATOM 2066 C CA . PRO A 1 271 ? 43.765 13.294 -6.521 1.00 17.50 ? 271 PRO A CA 1 ATOM 2067 C C . PRO A 1 271 ? 42.873 13.516 -5.309 1.00 16.85 ? 271 PRO A C 1 ATOM 2068 O O . PRO A 1 271 ? 41.784 14.068 -5.438 1.00 16.96 ? 271 PRO A O 1 ATOM 2069 C CB . PRO A 1 271 ? 43.931 11.794 -6.793 1.00 17.73 ? 271 PRO A CB 1 ATOM 2070 C CG . PRO A 1 271 ? 45.310 11.673 -7.252 1.00 18.71 ? 271 PRO A CG 1 ATOM 2071 C CD . PRO A 1 271 ? 46.091 12.624 -6.396 1.00 18.19 ? 271 PRO A CD 1 ATOM 2072 N N . GLY A 1 272 ? 43.361 13.086 -4.146 1.00 16.88 ? 272 GLY A N 1 ATOM 2073 C CA . GLY A 1 272 ? 42.695 13.318 -2.869 1.00 16.55 ? 272 GLY A CA 1 ATOM 2074 C C . GLY A 1 272 ? 43.535 14.239 -2.005 1.00 16.10 ? 272 GLY A C 1 ATOM 2075 O O . GLY A 1 272 ? 43.987 15.286 -2.449 1.00 16.03 ? 272 GLY A O 1 ATOM 2076 N N . ASP A 1 273 ? 43.719 13.853 -0.753 1.00 16.57 ? 273 ASP A N 1 ATOM 2077 C CA . ASP A 1 273 ? 44.503 14.645 0.183 1.00 16.36 ? 273 ASP A CA 1 ATOM 2078 C C . ASP A 1 273 ? 45.959 14.661 -0.250 1.00 16.92 ? 273 ASP A C 1 ATOM 2079 O O . ASP A 1 273 ? 46.435 13.732 -0.908 1.00 16.58 ? 273 ASP A O 1 ATOM 2080 C CB . ASP A 1 273 ? 44.406 14.052 1.590 1.00 16.67 ? 273 ASP A CB 1 ATOM 2081 C CG . ASP A 1 273 ? 43.009 14.084 2.145 1.00 16.20 ? 273 ASP A CG 1 ATOM 2082 O OD1 . ASP A 1 273 ? 42.245 15.014 1.831 1.00 14.07 ? 273 ASP A OD1 1 ATOM 2083 O OD2 . ASP A 1 273 ? 42.591 13.215 2.929 1.00 18.46 ? 273 ASP A OD2 1 ATOM 2084 N N . MET A 1 274 ? 46.679 15.707 0.127 1.00 16.72 ? 274 MET A N 1 ATOM 2085 C CA . MET A 1 274 ? 48.096 15.743 -0.163 1.00 17.71 ? 274 MET A CA 1 ATOM 2086 C C . MET A 1 274 ? 48.816 14.748 0.716 1.00 16.44 ? 274 MET A C 1 ATOM 2087 O O . MET A 1 274 ? 48.277 14.306 1.719 1.00 16.34 ? 274 MET A O 1 ATOM 2088 C CB . MET A 1 274 ? 48.632 17.154 -0.046 1.00 16.99 ? 274 MET A CB 1 ATOM 2089 C CG . MET A 1 274 ? 48.130 17.944 -1.247 1.00 19.88 ? 274 MET A CG 1 ATOM 2090 S SD . MET A 1 274 ? 48.580 19.639 -1.200 1.00 22.95 ? 274 MET A SD 1 ATOM 2091 C CE . MET A 1 274 ? 50.332 19.502 -1.610 1.00 22.49 ? 274 MET A CE 1 ATOM 2092 N N . LYS A 1 275 ? 50.002 14.334 0.301 1.00 16.00 ? 275 LYS A N 1 ATOM 2093 C CA . LYS A 1 275 ? 50.766 13.379 1.087 1.00 16.73 ? 275 LYS A CA 1 ATOM 2094 C C . LYS A 1 275 ? 51.213 14.042 2.378 1.00 16.42 ? 275 LYS A C 1 ATOM 2095 O O . LYS A 1 275 ? 51.377 15.263 2.430 1.00 16.33 ? 275 LYS A O 1 ATOM 2096 C CB . LYS A 1 275 ? 51.981 12.880 0.307 1.00 17.07 ? 275 LYS A CB 1 ATOM 2097 C CG . LYS A 1 275 ? 51.573 12.168 -0.973 1.00 19.42 ? 275 LYS A CG 1 ATOM 2098 C CD . LYS A 1 275 ? 52.655 11.293 -1.525 1.00 24.29 ? 275 LYS A CD 1 ATOM 2099 C CE . LYS A 1 275 ? 52.075 10.308 -2.525 1.00 26.29 ? 275 LYS A CE 1 ATOM 2100 N NZ . LYS A 1 275 ? 51.706 11.011 -3.776 1.00 29.91 ? 275 LYS A NZ 1 ATOM 2101 N N . TYR A 1 276 ? 51.407 13.237 3.414 1.00 16.66 ? 276 TYR A N 1 ATOM 2102 C CA . TYR A 1 276 ? 52.053 13.712 4.623 1.00 16.61 ? 276 TYR A CA 1 ATOM 2103 C C . TYR A 1 276 ? 53.371 14.357 4.230 1.00 16.98 ? 276 TYR A C 1 ATOM 2104 O O . TYR A 1 276 ? 54.019 13.926 3.265 1.00 17.03 ? 276 TYR A O 1 ATOM 2105 C CB . TYR A 1 276 ? 52.318 12.559 5.591 1.00 16.30 ? 276 TYR A CB 1 ATOM 2106 C CG . TYR A 1 276 ? 51.078 12.061 6.305 1.00 15.60 ? 276 TYR A CG 1 ATOM 2107 C CD1 . TYR A 1 276 ? 50.527 10.818 6.010 1.00 14.10 ? 276 TYR A CD1 1 ATOM 2108 C CD2 . TYR A 1 276 ? 50.451 12.840 7.274 1.00 15.11 ? 276 TYR A CD2 1 ATOM 2109 C CE1 . TYR A 1 276 ? 49.382 10.358 6.670 1.00 14.19 ? 276 TYR A CE1 1 ATOM 2110 C CE2 . TYR A 1 276 ? 49.305 12.387 7.942 1.00 14.97 ? 276 TYR A CE2 1 ATOM 2111 C CZ . TYR A 1 276 ? 48.777 11.143 7.638 1.00 15.13 ? 276 TYR A CZ 1 ATOM 2112 O OH . TYR A 1 276 ? 47.656 10.682 8.308 1.00 15.16 ? 276 TYR A OH 1 ATOM 2113 N N . GLU A 1 277 ? 53.755 15.390 4.967 1.00 17.68 ? 277 GLU A N 1 ATOM 2114 C CA . GLU A 1 277 ? 54.965 16.146 4.675 1.00 17.73 ? 277 GLU A CA 1 ATOM 2115 C C . GLU A 1 277 ? 56.178 15.249 4.586 1.00 18.39 ? 277 GLU A C 1 ATOM 2116 O O . GLU A 1 277 ? 57.027 15.456 3.734 1.00 18.42 ? 277 GLU A O 1 ATOM 2117 C CB . GLU A 1 277 ? 55.197 17.207 5.745 1.00 18.19 ? 277 GLU A CB 1 ATOM 2118 C CG . GLU A 1 277 ? 56.529 17.927 5.652 1.00 17.90 ? 277 GLU A CG 1 ATOM 2119 C CD . GLU A 1 277 ? 56.744 18.648 4.336 1.00 19.32 ? 277 GLU A CD 1 ATOM 2120 O OE1 . GLU A 1 277 ? 55.756 18.939 3.639 1.00 18.33 ? 277 GLU A OE1 1 ATOM 2121 O OE2 . GLU A 1 277 ? 57.917 18.932 3.991 1.00 17.84 ? 277 GLU A OE2 1 ATOM 2122 N N . ILE A 1 278 ? 56.255 14.264 5.478 1.00 18.94 ? 278 ILE A N 1 ATOM 2123 C CA . ILE A 1 278 ? 57.332 13.268 5.449 1.00 19.13 ? 278 ILE A CA 1 ATOM 2124 C C . ILE A 1 278 ? 57.356 12.397 4.184 1.00 18.80 ? 278 ILE A C 1 ATOM 2125 O O . ILE A 1 278 ? 58.387 11.807 3.874 1.00 18.76 ? 278 ILE A O 1 ATOM 2126 C CB . ILE A 1 278 ? 57.286 12.357 6.701 1.00 19.33 ? 278 ILE A CB 1 ATOM 2127 C CG1 . ILE A 1 278 ? 55.960 11.596 6.786 1.00 19.60 ? 278 ILE A CG1 1 ATOM 2128 C CG2 . ILE A 1 278 ? 57.577 13.184 7.961 1.00 20.18 ? 278 ILE A CG2 1 ATOM 2129 C CD1 . ILE A 1 278 ? 55.927 10.489 7.825 1.00 20.73 ? 278 ILE A CD1 1 ATOM 2130 N N . HIS A 1 279 ? 56.232 12.310 3.472 1.00 18.51 ? 279 HIS A N 1 ATOM 2131 C CA . HIS A 1 279 ? 56.167 11.585 2.206 1.00 18.59 ? 279 HIS A CA 1 ATOM 2132 C C . HIS A 1 279 ? 56.117 12.502 0.990 1.00 18.82 ? 279 HIS A C 1 ATOM 2133 O O . HIS A 1 279 ? 56.007 12.015 -0.120 1.00 19.37 ? 279 HIS A O 1 ATOM 2134 C CB . HIS A 1 279 ? 54.942 10.669 2.186 1.00 18.64 ? 279 HIS A CB 1 ATOM 2135 C CG . HIS A 1 279 ? 54.898 9.702 3.325 1.00 18.28 ? 279 HIS A CG 1 ATOM 2136 N ND1 . HIS A 1 279 ? 53.720 9.233 3.860 1.00 18.52 ? 279 HIS A ND1 1 ATOM 2137 C CD2 . HIS A 1 279 ? 55.893 9.136 4.048 1.00 19.53 ? 279 HIS A CD2 1 ATOM 2138 C CE1 . HIS A 1 279 ? 53.989 8.409 4.858 1.00 20.42 ? 279 HIS A CE1 1 ATOM 2139 N NE2 . HIS A 1 279 ? 55.301 8.339 4.999 1.00 20.27 ? 279 HIS A NE2 1 ATOM 2140 N N . ARG A 1 280 ? 56.193 13.818 1.185 1.00 19.52 ? 280 ARG A N 1 ATOM 2141 C CA . ARG A 1 280 ? 56.022 14.770 0.079 1.00 19.73 ? 280 ARG A CA 1 ATOM 2142 C C . ARG A 1 280 ? 57.164 14.686 -0.924 1.00 20.77 ? 280 ARG A C 1 ATOM 2143 O O . ARG A 1 280 ? 58.330 14.659 -0.548 1.00 21.21 ? 280 ARG A O 1 ATOM 2144 C CB . ARG A 1 280 ? 55.900 16.211 0.591 1.00 19.61 ? 280 ARG A CB 1 ATOM 2145 C CG . ARG A 1 280 ? 55.585 17.214 -0.493 1.00 18.79 ? 280 ARG A CG 1 ATOM 2146 C CD . ARG A 1 280 ? 55.332 18.634 -0.012 1.00 19.20 ? 280 ARG A CD 1 ATOM 2147 N NE . ARG A 1 280 ? 56.421 19.119 0.807 1.00 17.03 ? 280 ARG A NE 1 ATOM 2148 C CZ . ARG A 1 280 ? 57.516 19.716 0.367 1.00 16.89 ? 280 ARG A CZ 1 ATOM 2149 N NH1 . ARG A 1 280 ? 58.438 20.089 1.245 1.00 17.81 ? 280 ARG A NH1 1 ATOM 2150 N NH2 . ARG A 1 280 ? 57.717 19.932 -0.923 1.00 16.08 ? 280 ARG A NH2 1 ATOM 2151 N N . ASP A 1 281 ? 56.808 14.610 -2.198 1.00 21.50 ? 281 ASP A N 1 ATOM 2152 C CA . ASP A 1 281 ? 57.767 14.713 -3.283 1.00 22.12 ? 281 ASP A CA 1 ATOM 2153 C C . ASP A 1 281 ? 58.022 16.197 -3.518 1.00 21.94 ? 281 ASP A C 1 ATOM 2154 O O . ASP A 1 281 ? 57.169 16.908 -4.039 1.00 21.94 ? 281 ASP A O 1 ATOM 2155 C CB . ASP A 1 281 ? 57.185 14.054 -4.532 1.00 22.20 ? 281 ASP A CB 1 ATOM 2156 C CG . ASP A 1 281 ? 58.166 13.978 -5.670 1.00 23.68 ? 281 ASP A CG 1 ATOM 2157 O OD1 . ASP A 1 281 ? 58.966 14.917 -5.882 1.00 23.52 ? 281 ASP A OD1 1 ATOM 2158 O OD2 . ASP A 1 281 ? 58.172 12.998 -6.438 1.00 26.36 ? 281 ASP A OD2 1 ATOM 2159 N N . SER A 1 282 ? 59.198 16.663 -3.124 1.00 22.53 ? 282 SER A N 1 ATOM 2160 C CA . SER A 1 282 ? 59.497 18.088 -3.139 1.00 23.44 ? 282 SER A CA 1 ATOM 2161 C C . SER A 1 282 ? 59.730 18.642 -4.539 1.00 23.81 ? 282 SER A C 1 ATOM 2162 O O . SER A 1 282 ? 59.834 19.856 -4.703 1.00 24.68 ? 282 SER A O 1 ATOM 2163 C CB . SER A 1 282 ? 60.697 18.384 -2.250 1.00 23.73 ? 282 SER A CB 1 ATOM 2164 O OG . SER A 1 282 ? 61.824 17.639 -2.661 1.00 24.81 ? 282 SER A OG 1 ATOM 2165 N N . THR A 1 283 ? 59.812 17.775 -5.546 1.00 23.77 ? 283 THR A N 1 ATOM 2166 C CA . THR A 1 283 ? 59.848 18.245 -6.921 1.00 23.87 ? 283 THR A CA 1 ATOM 2167 C C . THR A 1 283 ? 58.435 18.419 -7.458 1.00 23.49 ? 283 THR A C 1 ATOM 2168 O O . THR A 1 283 ? 58.185 19.351 -8.204 1.00 23.67 ? 283 THR A O 1 ATOM 2169 C CB . THR A 1 283 ? 60.677 17.304 -7.838 1.00 23.82 ? 283 THR A CB 1 ATOM 2170 O OG1 . THR A 1 283 ? 60.126 15.984 -7.833 1.00 26.83 ? 283 THR A OG1 1 ATOM 2171 C CG2 . THR A 1 283 ? 62.060 17.110 -7.307 1.00 24.05 ? 283 THR A CG2 1 ATOM 2172 N N . LEU A 1 284 ? 57.513 17.530 -7.066 1.00 23.03 ? 284 LEU A N 1 ATOM 2173 C CA . LEU A 1 284 ? 56.165 17.515 -7.635 1.00 22.66 ? 284 LEU A CA 1 ATOM 2174 C C . LEU A 1 284 ? 55.141 18.316 -6.826 1.00 21.74 ? 284 LEU A C 1 ATOM 2175 O O . LEU A 1 284 ? 54.188 18.845 -7.389 1.00 21.93 ? 284 LEU A O 1 ATOM 2176 C CB . LEU A 1 284 ? 55.662 16.073 -7.804 1.00 23.09 ? 284 LEU A CB 1 ATOM 2177 C CG . LEU A 1 284 ? 55.907 15.405 -9.169 1.00 24.31 ? 284 LEU A CG 1 ATOM 2178 C CD1 . LEU A 1 284 ? 55.017 15.994 -10.261 1.00 24.87 ? 284 LEU A CD1 1 ATOM 2179 C CD2 . LEU A 1 284 ? 57.353 15.524 -9.557 1.00 24.76 ? 284 LEU A CD2 1 ATOM 2180 N N . ASP A 1 285 ? 55.342 18.385 -5.516 1.00 20.90 ? 285 ASP A N 1 ATOM 2181 C CA . ASP A 1 285 ? 54.345 18.936 -4.592 1.00 20.32 ? 285 ASP A CA 1 ATOM 2182 C C . ASP A 1 285 ? 54.858 20.033 -3.667 1.00 19.17 ? 285 ASP A C 1 ATOM 2183 O O . ASP A 1 285 ? 55.911 19.888 -3.051 1.00 18.33 ? 285 ASP A O 1 ATOM 2184 C CB . ASP A 1 285 ? 53.770 17.806 -3.760 1.00 20.75 ? 285 ASP A CB 1 ATOM 2185 C CG . ASP A 1 285 ? 52.862 16.933 -4.561 1.00 22.19 ? 285 ASP A CG 1 ATOM 2186 O OD1 . ASP A 1 285 ? 51.626 17.090 -4.435 1.00 26.10 ? 285 ASP A OD1 1 ATOM 2187 O OD2 . ASP A 1 285 ? 53.293 16.100 -5.384 1.00 21.75 ? 285 ASP A OD2 1 ATOM 2188 N N . PRO A 1 286 ? 54.097 21.125 -3.543 1.00 18.02 ? 286 PRO A N 1 ATOM 2189 C CA . PRO A 1 286 ? 54.464 22.183 -2.633 1.00 17.56 ? 286 PRO A CA 1 ATOM 2190 C C . PRO A 1 286 ? 54.086 21.780 -1.210 1.00 16.91 ? 286 PRO A C 1 ATOM 2191 O O . PRO A 1 286 ? 53.082 21.088 -1.004 1.00 17.11 ? 286 PRO A O 1 ATOM 2192 C CB . PRO A 1 286 ? 53.623 23.373 -3.114 1.00 17.93 ? 286 PRO A CB 1 ATOM 2193 C CG . PRO A 1 286 ? 52.351 22.716 -3.642 1.00 17.75 ? 286 PRO A CG 1 ATOM 2194 C CD . PRO A 1 286 ? 52.813 21.398 -4.216 1.00 18.31 ? 286 PRO A CD 1 ATOM 2195 N N . SER A 1 287 ? 54.916 22.160 -0.249 1.00 16.21 ? 287 SER A N 1 ATOM 2196 C CA . SER A 1 287 ? 54.551 22.042 1.165 1.00 15.27 ? 287 SER A CA 1 ATOM 2197 C C . SER A 1 287 ? 53.462 23.044 1.496 1.00 14.77 ? 287 SER A C 1 ATOM 2198 O O . SER A 1 287 ? 53.177 23.973 0.720 1.00 15.02 ? 287 SER A O 1 ATOM 2199 C CB . SER A 1 287 ? 55.749 22.334 2.060 1.00 15.03 ? 287 SER A CB 1 ATOM 2200 O OG . SER A 1 287 ? 56.073 23.707 1.989 1.00 12.88 ? 287 SER A OG 1 ATOM 2201 N N . LEU A 1 288 ? 52.861 22.872 2.661 1.00 14.82 ? 288 LEU A N 1 ATOM 2202 C CA . LEU A 1 288 ? 51.881 23.848 3.141 1.00 14.41 ? 288 LEU A CA 1 ATOM 2203 C C . LEU A 1 288 ? 52.486 25.250 3.184 1.00 14.00 ? 288 LEU A C 1 ATOM 2204 O O . LEU A 1 288 ? 51.841 26.214 2.784 1.00 12.93 ? 288 LEU A O 1 ATOM 2205 C CB . LEU A 1 288 ? 51.364 23.467 4.530 1.00 14.26 ? 288 LEU A CB 1 ATOM 2206 C CG . LEU A 1 288 ? 50.187 24.291 5.065 1.00 14.17 ? 288 LEU A CG 1 ATOM 2207 C CD1 . LEU A 1 288 ? 49.021 24.378 4.074 1.00 15.04 ? 288 LEU A CD1 1 ATOM 2208 C CD2 . LEU A 1 288 ? 49.718 23.709 6.386 1.00 14.64 ? 288 LEU A CD2 1 ATOM 2209 N N . MET A 1 289 ? 53.726 25.360 3.659 1.00 14.22 ? 289 MET A N 1 ATOM 2210 C CA . MET A 1 289 ? 54.391 26.655 3.740 1.00 15.26 ? 289 MET A CA 1 ATOM 2211 C C . MET A 1 289 ? 54.512 27.275 2.345 1.00 14.64 ? 289 MET A C 1 ATOM 2212 O O . MET A 1 289 ? 54.241 28.464 2.137 1.00 15.22 ? 289 MET A O 1 ATOM 2213 C CB . MET A 1 289 ? 55.780 26.507 4.355 1.00 15.24 ? 289 MET A CB 1 ATOM 2214 C CG . MET A 1 289 ? 56.489 27.844 4.556 1.00 16.34 ? 289 MET A CG 1 ATOM 2215 S SD . MET A 1 289 ? 58.075 27.684 5.388 1.00 17.64 ? 289 MET A SD 1 ATOM 2216 C CE . MET A 1 289 ? 59.040 26.785 4.187 1.00 19.69 ? 289 MET A CE 1 ATOM 2217 N N . GLU A 1 290 ? 54.915 26.457 1.385 1.00 14.39 ? 290 GLU A N 1 ATOM 2218 C CA . GLU A 1 290 ? 55.080 26.922 0.010 1.00 14.31 ? 290 GLU A CA 1 ATOM 2219 C C . GLU A 1 290 ? 53.764 27.357 -0.608 1.00 14.31 ? 290 GLU A C 1 ATOM 2220 O O . GLU A 1 290 ? 53.698 28.384 -1.280 1.00 13.73 ? 290 GLU A O 1 ATOM 2221 C CB . GLU A 1 290 ? 55.728 25.822 -0.823 1.00 14.64 ? 290 GLU A CB 1 ATOM 2222 C CG . GLU A 1 290 ? 57.189 25.669 -0.469 1.00 16.06 ? 290 GLU A CG 1 ATOM 2223 C CD . GLU A 1 290 ? 57.860 24.506 -1.161 1.00 18.51 ? 290 GLU A CD 1 ATOM 2224 O OE1 . GLU A 1 290 ? 57.155 23.668 -1.764 1.00 20.38 ? 290 GLU A OE1 1 ATOM 2225 O OE2 . GLU A 1 290 ? 59.114 24.433 -1.088 1.00 19.10 ? 290 GLU A OE2 1 ATOM 2226 N N . MET A 1 291 ? 52.711 26.579 -0.376 1.00 14.44 ? 291 MET A N 1 ATOM 2227 C CA . MET A 1 291 ? 51.374 26.947 -0.846 1.00 14.40 ? 291 MET A CA 1 ATOM 2228 C C . MET A 1 291 ? 50.878 28.240 -0.218 1.00 15.42 ? 291 MET A C 1 ATOM 2229 O O . MET A 1 291 ? 50.251 29.073 -0.909 1.00 13.72 ? 291 MET A O 1 ATOM 2230 C CB . MET A 1 291 ? 50.378 25.844 -0.567 1.00 14.39 ? 291 MET A CB 1 ATOM 2231 C CG . MET A 1 291 ? 50.587 24.609 -1.423 1.00 13.86 ? 291 MET A CG 1 ATOM 2232 S SD . MET A 1 291 ? 49.225 23.460 -1.306 1.00 15.62 ? 291 MET A SD 1 ATOM 2233 C CE . MET A 1 291 ? 49.337 22.969 0.403 1.00 14.75 ? 291 MET A CE 1 ATOM 2234 N N . THR A 1 292 ? 51.167 28.447 1.076 1.00 14.51 ? 292 THR A N 1 ATOM 2235 C CA . THR A 1 292 ? 50.667 29.683 1.680 1.00 15.15 ? 292 THR A CA 1 ATOM 2236 C C . THR A 1 292 ? 51.443 30.905 1.178 1.00 14.78 ? 292 THR A C 1 ATOM 2237 O O . THR A 1 292 ? 50.837 31.953 0.956 1.00 14.51 ? 292 THR A O 1 ATOM 2238 C CB . THR A 1 292 ? 50.468 29.638 3.248 1.00 15.72 ? 292 THR A CB 1 ATOM 2239 O OG1 . THR A 1 292 ? 51.398 30.479 3.921 1.00 17.82 ? 292 THR A OG1 1 ATOM 2240 C CG2 . THR A 1 292 ? 50.609 28.278 3.833 1.00 12.09 ? 292 THR A CG2 1 ATOM 2241 N N . GLU A 1 293 ? 52.748 30.756 0.916 1.00 14.78 ? 293 GLU A N 1 ATOM 2242 C CA . GLU A 1 293 ? 53.494 31.807 0.212 1.00 14.74 ? 293 GLU A CA 1 ATOM 2243 C C . GLU A 1 293 ? 52.960 32.064 -1.205 1.00 14.45 ? 293 GLU A C 1 ATOM 2244 O O . GLU A 1 293 ? 52.845 33.214 -1.626 1.00 15.19 ? 293 GLU A O 1 ATOM 2245 C CB . GLU A 1 293 ? 54.985 31.499 0.174 1.00 14.66 ? 293 GLU A CB 1 ATOM 2246 C CG . GLU A 1 293 ? 55.817 32.539 -0.573 1.00 15.12 ? 293 GLU A CG 1 ATOM 2247 C CD . GLU A 1 293 ? 57.271 32.556 -0.165 1.00 14.68 ? 293 GLU A CD 1 ATOM 2248 O OE1 . GLU A 1 293 ? 57.998 33.500 -0.578 1.00 15.61 ? 293 GLU A OE1 1 ATOM 2249 O OE2 . GLU A 1 293 ? 57.694 31.659 0.593 1.00 15.76 ? 293 GLU A OE2 1 ATOM 2250 N N . ALA A 1 294 ? 52.689 31.004 -1.954 1.00 14.16 ? 294 ALA A N 1 ATOM 2251 C CA . ALA A 1 294 ? 52.087 31.137 -3.282 1.00 14.22 ? 294 ALA A CA 1 ATOM 2252 C C . ALA A 1 294 ? 50.776 31.913 -3.216 1.00 14.37 ? 294 ALA A C 1 ATOM 2253 O O . ALA A 1 294 ? 50.523 32.793 -4.037 1.00 13.37 ? 294 ALA A O 1 ATOM 2254 C CB . ALA A 1 294 ? 51.858 29.756 -3.900 1.00 14.87 ? 294 ALA A CB 1 ATOM 2255 N N . ALA A 1 295 ? 49.951 31.598 -2.220 1.00 13.42 ? 295 ALA A N 1 ATOM 2256 C CA . ALA A 1 295 ? 48.679 32.287 -2.041 1.00 13.70 ? 295 ALA A CA 1 ATOM 2257 C C . ALA A 1 295 ? 48.902 33.752 -1.731 1.00 14.05 ? 295 ALA A C 1 ATOM 2258 O O . ALA A 1 295 ? 48.237 34.626 -2.296 1.00 13.69 ? 295 ALA A O 1 ATOM 2259 C CB . ALA A 1 295 ? 47.891 31.646 -0.940 1.00 13.56 ? 295 ALA A CB 1 ATOM 2260 N N . LEU A 1 296 ? 49.836 34.008 -0.825 1.00 14.24 ? 296 LEU A N 1 ATOM 2261 C CA . LEU A 1 296 ? 50.110 35.371 -0.384 1.00 15.95 ? 296 LEU A CA 1 ATOM 2262 C C . LEU A 1 296 ? 50.637 36.239 -1.519 1.00 15.81 ? 296 LEU A C 1 ATOM 2263 O O . LEU A 1 296 ? 50.305 37.414 -1.596 1.00 15.50 ? 296 LEU A O 1 ATOM 2264 C CB . LEU A 1 296 ? 51.089 35.359 0.792 1.00 15.77 ? 296 LEU A CB 1 ATOM 2265 C CG . LEU A 1 296 ? 50.638 35.631 2.244 1.00 18.26 ? 296 LEU A CG 1 ATOM 2266 C CD1 . LEU A 1 296 ? 49.157 35.667 2.493 1.00 19.14 ? 296 LEU A CD1 1 ATOM 2267 C CD2 . LEU A 1 296 ? 51.360 34.739 3.241 1.00 17.50 ? 296 LEU A CD2 1 ATOM 2268 N N . ARG A 1 297 ? 51.448 35.650 -2.397 1.00 16.42 ? 297 ARG A N 1 ATOM 2269 C CA . ARG A 1 297 ? 51.963 36.348 -3.587 1.00 17.04 ? 297 ARG A CA 1 ATOM 2270 C C . ARG A 1 297 ? 50.835 36.924 -4.418 1.00 17.45 ? 297 ARG A C 1 ATOM 2271 O O . ARG A 1 297 ? 50.887 38.076 -4.798 1.00 17.48 ? 297 ARG A O 1 ATOM 2272 C CB . ARG A 1 297 ? 52.793 35.404 -4.450 1.00 16.88 ? 297 ARG A CB 1 ATOM 2273 C CG . ARG A 1 297 ? 54.170 35.118 -3.879 1.00 17.01 ? 297 ARG A CG 1 ATOM 2274 C CD . ARG A 1 297 ? 54.915 34.041 -4.597 1.00 16.76 ? 297 ARG A CD 1 ATOM 2275 N NE . ARG A 1 297 ? 56.281 33.956 -4.110 1.00 16.02 ? 297 ARG A NE 1 ATOM 2276 C CZ . ARG A 1 297 ? 57.172 33.080 -4.533 1.00 15.71 ? 297 ARG A CZ 1 ATOM 2277 N NH1 . ARG A 1 297 ? 58.391 33.086 -4.023 1.00 15.47 ? 297 ARG A NH1 1 ATOM 2278 N NH2 . ARG A 1 297 ? 56.863 32.192 -5.462 1.00 17.67 ? 297 ARG A NH2 1 ATOM 2279 N N . LEU A 1 298 ? 49.796 36.124 -4.640 1.00 18.45 ? 298 LEU A N 1 ATOM 2280 C CA . LEU A 1 298 ? 48.658 36.522 -5.458 1.00 19.09 ? 298 LEU A CA 1 ATOM 2281 C C . LEU A 1 298 ? 47.665 37.402 -4.669 1.00 18.27 ? 298 LEU A C 1 ATOM 2282 O O . LEU A 1 298 ? 47.232 38.448 -5.142 1.00 18.39 ? 298 LEU A O 1 ATOM 2283 C CB . LEU A 1 298 ? 47.996 35.242 -6.004 1.00 19.35 ? 298 LEU A CB 1 ATOM 2284 C CG . LEU A 1 298 ? 46.843 35.240 -7.015 1.00 21.16 ? 298 LEU A CG 1 ATOM 2285 C CD1 . LEU A 1 298 ? 47.014 36.311 -8.055 1.00 25.23 ? 298 LEU A CD1 1 ATOM 2286 C CD2 . LEU A 1 298 ? 46.692 33.858 -7.698 1.00 21.52 ? 298 LEU A CD2 1 ATOM 2287 N N . LEU A 1 299 ? 47.316 36.976 -3.456 1.00 17.80 ? 299 LEU A N 1 ATOM 2288 C CA . LEU A 1 299 ? 46.315 37.673 -2.636 1.00 17.50 ? 299 LEU A CA 1 ATOM 2289 C C . LEU A 1 299 ? 46.729 39.073 -2.194 1.00 17.26 ? 299 LEU A C 1 ATOM 2290 O O . LEU A 1 299 ? 45.891 39.963 -2.047 1.00 16.81 ? 299 LEU A O 1 ATOM 2291 C CB . LEU A 1 299 ? 46.021 36.853 -1.381 1.00 17.35 ? 299 LEU A CB 1 ATOM 2292 C CG . LEU A 1 299 ? 45.303 35.537 -1.646 1.00 17.44 ? 299 LEU A CG 1 ATOM 2293 C CD1 . LEU A 1 299 ? 45.091 34.789 -0.348 1.00 17.96 ? 299 LEU A CD1 1 ATOM 2294 C CD2 . LEU A 1 299 ? 43.978 35.793 -2.356 1.00 18.11 ? 299 LEU A CD2 1 ATOM 2295 N N . SER A 1 300 ? 48.019 39.251 -1.950 1.00 17.30 ? 300 SER A N 1 ATOM 2296 C CA . SER A 1 300 ? 48.540 40.514 -1.465 1.00 18.66 ? 300 SER A CA 1 ATOM 2297 C C . SER A 1 300 ? 48.479 41.634 -2.518 1.00 19.09 ? 300 SER A C 1 ATOM 2298 O O . SER A 1 300 ? 48.680 42.798 -2.188 1.00 19.82 ? 300 SER A O 1 ATOM 2299 C CB . SER A 1 300 ? 49.973 40.329 -0.941 1.00 18.65 ? 300 SER A CB 1 ATOM 2300 O OG . SER A 1 300 ? 50.860 40.077 -2.010 1.00 20.81 ? 300 SER A OG 1 ATOM 2301 N N . ARG A 1 301 ? 48.195 41.293 -3.769 1.00 19.79 ? 301 ARG A N 1 ATOM 2302 C CA . ARG A 1 301 ? 48.128 42.291 -4.837 1.00 20.75 ? 301 ARG A CA 1 ATOM 2303 C C . ARG A 1 301 ? 46.883 43.208 -4.745 1.00 20.77 ? 301 ARG A C 1 ATOM 2304 O O . ARG A 1 301 ? 46.913 44.348 -5.218 1.00 20.60 ? 301 ARG A O 1 ATOM 2305 C CB . ARG A 1 301 ? 48.192 41.599 -6.207 1.00 21.12 ? 301 ARG A CB 1 ATOM 2306 C CG . ARG A 1 301 ? 49.510 40.868 -6.496 1.00 22.93 ? 301 ARG A CG 1 ATOM 2307 C CD . ARG A 1 301 ? 49.526 40.223 -7.902 1.00 23.30 ? 301 ARG A CD 1 ATOM 2308 N NE . ARG A 1 301 ? 50.502 39.163 -8.253 1.00 25.41 ? 301 ARG A NE 1 ATOM 2309 C CZ . ARG A 1 301 ? 51.701 38.896 -7.683 1.00 27.92 ? 301 ARG A CZ 1 ATOM 2310 N NH1 . ARG A 1 301 ? 52.211 39.613 -6.678 1.00 29.48 ? 301 ARG A NH1 1 ATOM 2311 N NH2 . ARG A 1 301 ? 52.430 37.874 -8.155 1.00 27.83 ? 301 ARG A NH2 1 ATOM 2312 N N . ASN A 1 302 ? 45.806 42.715 -4.129 1.00 20.30 ? 302 ASN A N 1 ATOM 2313 C CA . ASN A 1 302 ? 44.560 43.479 -3.974 1.00 20.38 ? 302 ASN A CA 1 ATOM 2314 C C . ASN A 1 302 ? 44.717 44.608 -2.952 1.00 20.67 ? 302 ASN A C 1 ATOM 2315 O O . ASN A 1 302 ? 44.963 44.341 -1.778 1.00 20.22 ? 302 ASN A O 1 ATOM 2316 C CB . ASN A 1 302 ? 43.447 42.529 -3.519 1.00 20.56 ? 302 ASN A CB 1 ATOM 2317 C CG . ASN A 1 302 ? 42.061 43.104 -3.689 1.00 19.73 ? 302 ASN A CG 1 ATOM 2318 O OD1 . ASN A 1 302 ? 41.083 42.349 -3.839 1.00 19.88 ? 302 ASN A OD1 1 ATOM 2319 N ND2 . ASN A 1 302 ? 41.953 44.430 -3.668 1.00 14.88 ? 302 ASN A ND2 1 ATOM 2320 N N . PRO A 1 303 ? 44.571 45.869 -3.363 1.00 21.40 ? 303 PRO A N 1 ATOM 2321 C CA . PRO A 1 303 ? 44.713 46.982 -2.412 1.00 21.77 ? 303 PRO A CA 1 ATOM 2322 C C . PRO A 1 303 ? 43.682 47.009 -1.279 1.00 21.71 ? 303 PRO A C 1 ATOM 2323 O O . PRO A 1 303 ? 43.922 47.643 -0.254 1.00 21.71 ? 303 PRO A O 1 ATOM 2324 C CB . PRO A 1 303 ? 44.559 48.221 -3.295 1.00 22.11 ? 303 PRO A CB 1 ATOM 2325 C CG . PRO A 1 303 ? 43.809 47.754 -4.476 1.00 22.41 ? 303 PRO A CG 1 ATOM 2326 C CD . PRO A 1 303 ? 44.260 46.349 -4.719 1.00 21.75 ? 303 PRO A CD 1 ATOM 2327 N N . ARG A 1 304 ? 42.542 46.353 -1.479 1.00 21.53 ? 304 ARG A N 1 ATOM 2328 C CA . ARG A 1 304 ? 41.491 46.253 -0.456 1.00 22.74 ? 304 ARG A CA 1 ATOM 2329 C C . ARG A 1 304 ? 41.750 45.157 0.572 1.00 21.01 ? 304 ARG A C 1 ATOM 2330 O O . ARG A 1 304 ? 41.035 45.051 1.566 1.00 21.46 ? 304 ARG A O 1 ATOM 2331 C CB . ARG A 1 304 ? 40.142 46.007 -1.117 1.00 22.27 ? 304 ARG A CB 1 ATOM 2332 C CG . ARG A 1 304 ? 39.710 47.155 -1.993 1.00 24.97 ? 304 ARG A CG 1 ATOM 2333 C CD . ARG A 1 304 ? 38.429 46.884 -2.754 1.00 27.90 ? 304 ARG A CD 1 ATOM 2334 N NE . ARG A 1 304 ? 37.619 48.103 -2.869 1.00 33.45 ? 304 ARG A NE 1 ATOM 2335 C CZ . ARG A 1 304 ? 36.821 48.416 -3.899 1.00 36.29 ? 304 ARG A CZ 1 ATOM 2336 N NH1 . ARG A 1 304 ? 36.135 49.558 -3.863 1.00 36.79 ? 304 ARG A NH1 1 ATOM 2337 N NH2 . ARG A 1 304 ? 36.701 47.623 -4.966 1.00 38.61 ? 304 ARG A NH2 1 ATOM 2338 N N . GLY A 1 305 ? 42.767 44.346 0.317 1.00 19.96 ? 305 GLY A N 1 ATOM 2339 C CA . GLY A 1 305 ? 43.188 43.303 1.232 1.00 18.88 ? 305 GLY A CA 1 ATOM 2340 C C . GLY A 1 305 ? 42.718 41.925 0.834 1.00 17.89 ? 305 GLY A C 1 ATOM 2341 O O . GLY A 1 305 ? 42.180 41.715 -0.265 1.00 16.84 ? 305 GLY A O 1 ATOM 2342 N N . PHE A 1 306 ? 42.906 40.983 1.759 1.00 17.31 ? 306 PHE A N 1 ATOM 2343 C CA . PHE A 1 306 ? 42.550 39.607 1.526 1.00 16.55 ? 306 PHE A CA 1 ATOM 2344 C C . PHE A 1 306 ? 42.092 38.887 2.784 1.00 16.29 ? 306 PHE A C 1 ATOM 2345 O O . PHE A 1 306 ? 42.349 39.324 3.897 1.00 15.46 ? 306 PHE A O 1 ATOM 2346 C CB . PHE A 1 306 ? 43.727 38.855 0.894 1.00 16.97 ? 306 PHE A CB 1 ATOM 2347 C CG . PHE A 1 306 ? 44.938 38.735 1.781 1.00 16.77 ? 306 PHE A CG 1 ATOM 2348 C CD1 . PHE A 1 306 ? 45.061 37.683 2.684 1.00 17.62 ? 306 PHE A CD1 1 ATOM 2349 C CD2 . PHE A 1 306 ? 45.972 39.653 1.692 1.00 17.06 ? 306 PHE A CD2 1 ATOM 2350 C CE1 . PHE A 1 306 ? 46.183 37.573 3.497 1.00 16.97 ? 306 PHE A CE1 1 ATOM 2351 C CE2 . PHE A 1 306 ? 47.095 39.550 2.503 1.00 17.03 ? 306 PHE A CE2 1 ATOM 2352 C CZ . PHE A 1 306 ? 47.202 38.501 3.402 1.00 17.60 ? 306 PHE A CZ 1 ATOM 2353 N N . PHE A 1 307 ? 41.377 37.789 2.567 1.00 16.18 ? 307 PHE A N 1 ATOM 2354 C CA . PHE A 1 307 ? 41.088 36.795 3.584 1.00 15.81 ? 307 PHE A CA 1 ATOM 2355 C C . PHE A 1 307 ? 41.781 35.540 3.109 1.00 15.81 ? 307 PHE A C 1 ATOM 2356 O O . PHE A 1 307 ? 41.598 35.142 1.952 1.00 16.12 ? 307 PHE A O 1 ATOM 2357 C CB . PHE A 1 307 ? 39.584 36.530 3.690 1.00 16.24 ? 307 PHE A CB 1 ATOM 2358 C CG . PHE A 1 307 ? 39.229 35.410 4.641 1.00 15.36 ? 307 PHE A CG 1 ATOM 2359 C CD1 . PHE A 1 307 ? 39.386 34.070 4.269 1.00 16.13 ? 307 PHE A CD1 1 ATOM 2360 C CD2 . PHE A 1 307 ? 38.726 35.694 5.907 1.00 15.20 ? 307 PHE A CD2 1 ATOM 2361 C CE1 . PHE A 1 307 ? 39.064 33.035 5.177 1.00 16.48 ? 307 PHE A CE1 1 ATOM 2362 C CE2 . PHE A 1 307 ? 38.394 34.681 6.785 1.00 16.21 ? 307 PHE A CE2 1 ATOM 2363 C CZ . PHE A 1 307 ? 38.556 33.345 6.410 1.00 15.59 ? 307 PHE A CZ 1 ATOM 2364 N N . LEU A 1 308 ? 42.593 34.936 3.975 1.00 14.54 ? 308 LEU A N 1 ATOM 2365 C CA . LEU A 1 308 ? 43.247 33.668 3.674 1.00 14.28 ? 308 LEU A CA 1 ATOM 2366 C C . LEU A 1 308 ? 42.944 32.630 4.752 1.00 13.48 ? 308 LEU A C 1 ATOM 2367 O O . LEU A 1 308 ? 43.070 32.909 5.949 1.00 13.57 ? 308 LEU A O 1 ATOM 2368 C CB . LEU A 1 308 ? 44.748 33.862 3.578 1.00 13.75 ? 308 LEU A CB 1 ATOM 2369 C CG . LEU A 1 308 ? 45.631 32.627 3.414 1.00 13.86 ? 308 LEU A CG 1 ATOM 2370 C CD1 . LEU A 1 308 ? 45.322 31.818 2.140 1.00 14.41 ? 308 LEU A CD1 1 ATOM 2371 C CD2 . LEU A 1 308 ? 47.079 33.063 3.436 1.00 14.33 ? 308 LEU A CD2 1 ATOM 2372 N N . PHE A 1 309 ? 42.574 31.439 4.291 1.00 13.41 ? 309 PHE A N 1 ATOM 2373 C CA . PHE A 1 309 ? 42.394 30.263 5.118 1.00 13.37 ? 309 PHE A CA 1 ATOM 2374 C C . PHE A 1 309 ? 43.552 29.322 4.799 1.00 13.48 ? 309 PHE A C 1 ATOM 2375 O O . PHE A 1 309 ? 43.762 28.989 3.636 1.00 13.16 ? 309 PHE A O 1 ATOM 2376 C CB . PHE A 1 309 ? 41.054 29.623 4.785 1.00 13.49 ? 309 PHE A CB 1 ATOM 2377 C CG . PHE A 1 309 ? 40.870 28.228 5.321 1.00 13.63 ? 309 PHE A CG 1 ATOM 2378 C CD1 . PHE A 1 309 ? 41.265 27.130 4.579 1.00 14.91 ? 309 PHE A CD1 1 ATOM 2379 C CD2 . PHE A 1 309 ? 40.232 28.010 6.540 1.00 15.37 ? 309 PHE A CD2 1 ATOM 2380 C CE1 . PHE A 1 309 ? 41.075 25.839 5.054 1.00 12.93 ? 309 PHE A CE1 1 ATOM 2381 C CE2 . PHE A 1 309 ? 40.025 26.721 7.014 1.00 15.04 ? 309 PHE A CE2 1 ATOM 2382 C CZ . PHE A 1 309 ? 40.449 25.638 6.275 1.00 14.27 ? 309 PHE A CZ 1 ATOM 2383 N N . VAL A 1 310 ? 44.310 28.944 5.832 1.00 12.91 ? 310 VAL A N 1 ATOM 2384 C CA . VAL A 1 310 ? 45.438 28.034 5.719 1.00 13.12 ? 310 VAL A CA 1 ATOM 2385 C C . VAL A 1 310 ? 45.223 26.924 6.729 1.00 13.14 ? 310 VAL A C 1 ATOM 2386 O O . VAL A 1 310 ? 45.123 27.181 7.945 1.00 12.51 ? 310 VAL A O 1 ATOM 2387 C CB . VAL A 1 310 ? 46.787 28.727 6.028 1.00 13.16 ? 310 VAL A CB 1 ATOM 2388 C CG1 . VAL A 1 310 ? 47.942 27.726 6.006 1.00 13.36 ? 310 VAL A CG1 1 ATOM 2389 C CG2 . VAL A 1 310 ? 47.046 29.849 5.043 1.00 13.66 ? 310 VAL A CG2 1 ATOM 2390 N N . GLU A 1 311 ? 45.145 25.693 6.228 1.00 13.26 ? 311 GLU A N 1 ATOM 2391 C CA . GLU A 1 311 ? 44.910 24.543 7.087 1.00 13.09 ? 311 GLU A CA 1 ATOM 2392 C C . GLU A 1 311 ? 46.034 23.516 7.101 1.00 13.43 ? 311 GLU A C 1 ATOM 2393 O O . GLU A 1 311 ? 46.415 22.968 6.051 1.00 14.27 ? 311 GLU A O 1 ATOM 2394 C CB . GLU A 1 311 ? 43.629 23.842 6.668 1.00 13.22 ? 311 GLU A CB 1 ATOM 2395 C CG . GLU A 1 311 ? 43.238 22.756 7.629 1.00 11.59 ? 311 GLU A CG 1 ATOM 2396 C CD . GLU A 1 311 ? 42.201 21.813 7.093 1.00 12.68 ? 311 GLU A CD 1 ATOM 2397 O OE1 . GLU A 1 311 ? 41.879 21.798 5.878 1.00 12.79 ? 311 GLU A OE1 1 ATOM 2398 O OE2 . GLU A 1 311 ? 41.698 21.083 7.933 1.00 11.85 ? 311 GLU A OE2 1 ATOM 2399 N N . GLY A 1 312 ? 46.537 23.242 8.302 1.00 13.04 ? 312 GLY A N 1 ATOM 2400 C CA . GLY A 1 312 ? 47.295 22.028 8.579 1.00 12.87 ? 312 GLY A CA 1 ATOM 2401 C C . GLY A 1 312 ? 46.287 20.906 8.741 1.00 12.92 ? 312 GLY A C 1 ATOM 2402 O O . GLY A 1 312 ? 45.967 20.470 9.843 1.00 13.34 ? 312 GLY A O 1 ATOM 2403 N N . GLY A 1 313 ? 45.794 20.425 7.613 1.00 12.94 ? 313 GLY A N 1 ATOM 2404 C CA . GLY A 1 313 ? 44.633 19.559 7.606 1.00 12.87 ? 313 GLY A CA 1 ATOM 2405 C C . GLY A 1 313 ? 44.899 18.115 7.945 1.00 12.79 ? 313 GLY A C 1 ATOM 2406 O O . GLY A 1 313 ? 43.971 17.397 8.264 1.00 12.31 ? 313 GLY A O 1 ATOM 2407 N N . ARG A 1 314 ? 46.162 17.694 7.910 1.00 12.75 ? 314 ARG A N 1 ATOM 2408 C CA . ARG A 1 314 ? 46.501 16.292 8.127 1.00 12.55 ? 314 ARG A CA 1 ATOM 2409 C C . ARG A 1 314 ? 47.137 16.010 9.495 1.00 12.49 ? 314 ARG A C 1 ATOM 2410 O O . ARG A 1 314 ? 47.472 14.863 9.809 1.00 12.10 ? 314 ARG A O 1 ATOM 2411 C CB . ARG A 1 314 ? 47.404 15.824 6.991 1.00 13.29 ? 314 ARG A CB 1 ATOM 2412 C CG . ARG A 1 314 ? 46.751 16.002 5.620 1.00 12.45 ? 314 ARG A CG 1 ATOM 2413 C CD . ARG A 1 314 ? 47.155 14.973 4.591 1.00 12.23 ? 314 ARG A CD 1 ATOM 2414 N NE . ARG A 1 314 ? 46.567 13.678 4.921 1.00 13.03 ? 314 ARG A NE 1 ATOM 2415 C CZ . ARG A 1 314 ? 47.068 12.496 4.565 1.00 14.30 ? 314 ARG A CZ 1 ATOM 2416 N NH1 . ARG A 1 314 ? 48.145 12.418 3.802 1.00 14.32 ? 314 ARG A NH1 1 ATOM 2417 N NH2 . ARG A 1 314 ? 46.456 11.378 4.956 1.00 14.62 ? 314 ARG A NH2 1 ATOM 2418 N N . ILE A 1 315 ? 47.279 17.048 10.321 1.00 12.18 ? 315 ILE A N 1 ATOM 2419 C CA . ILE A 1 315 ? 47.507 16.842 11.755 1.00 12.33 ? 315 ILE A CA 1 ATOM 2420 C C . ILE A 1 315 ? 46.463 15.835 12.271 1.00 12.69 ? 315 ILE A C 1 ATOM 2421 O O . ILE A 1 315 ? 46.787 14.835 12.919 1.00 13.10 ? 315 ILE A O 1 ATOM 2422 C CB . ILE A 1 315 ? 47.375 18.186 12.513 1.00 11.79 ? 315 ILE A CB 1 ATOM 2423 C CG1 . ILE A 1 315 ? 48.456 19.164 12.080 1.00 11.95 ? 315 ILE A CG1 1 ATOM 2424 C CG2 . ILE A 1 315 ? 47.443 17.968 14.024 1.00 12.61 ? 315 ILE A CG2 1 ATOM 2425 C CD1 . ILE A 1 315 ? 48.143 20.623 12.448 1.00 12.16 ? 315 ILE A CD1 1 ATOM 2426 N N . ASP A 1 316 ? 45.203 16.138 11.975 1.00 13.12 ? 316 ASP A N 1 ATOM 2427 C CA . ASP A 1 316 ? 44.032 15.323 12.329 1.00 13.24 ? 316 ASP A CA 1 ATOM 2428 C C . ASP A 1 316 ? 44.204 13.875 11.905 1.00 13.63 ? 316 ASP A C 1 ATOM 2429 O O . ASP A 1 316 ? 43.987 12.951 12.689 1.00 14.41 ? 316 ASP A O 1 ATOM 2430 C CB . ASP A 1 316 ? 42.787 15.938 11.647 1.00 12.93 ? 316 ASP A CB 1 ATOM 2431 C CG . ASP A 1 316 ? 41.454 15.240 12.006 1.00 11.77 ? 316 ASP A CG 1 ATOM 2432 O OD1 . ASP A 1 316 ? 40.831 14.684 11.099 1.00 10.21 ? 316 ASP A OD1 1 ATOM 2433 O OD2 . ASP A 1 316 ? 40.861 15.240 13.102 1.00 12.44 ? 316 ASP A OD2 1 ATOM 2434 N N . HIS A 1 317 ? 44.597 13.700 10.653 1.00 13.53 ? 317 HIS A N 1 ATOM 2435 C CA . HIS A 1 317 ? 44.740 12.389 10.049 1.00 14.05 ? 317 HIS A CA 1 ATOM 2436 C C . HIS A 1 317 ? 45.821 11.561 10.739 1.00 13.92 ? 317 HIS A C 1 ATOM 2437 O O . HIS A 1 317 ? 45.630 10.361 10.965 1.00 14.23 ? 317 HIS A O 1 ATOM 2438 C CB . HIS A 1 317 ? 45.066 12.558 8.567 1.00 13.59 ? 317 HIS A CB 1 ATOM 2439 C CG . HIS A 1 317 ? 43.951 13.166 7.779 1.00 13.91 ? 317 HIS A CG 1 ATOM 2440 N ND1 . HIS A 1 317 ? 44.001 13.317 6.410 1.00 16.01 ? 317 HIS A ND1 1 ATOM 2441 C CD2 . HIS A 1 317 ? 42.750 13.658 8.168 1.00 14.15 ? 317 HIS A CD2 1 ATOM 2442 C CE1 . HIS A 1 317 ? 42.876 13.870 5.991 1.00 14.47 ? 317 HIS A CE1 1 ATOM 2443 N NE2 . HIS A 1 317 ? 42.099 14.082 7.038 1.00 14.26 ? 317 HIS A NE2 1 ATOM 2444 N N . GLY A 1 318 ? 46.938 12.202 11.072 1.00 13.13 ? 318 GLY A N 1 ATOM 2445 C CA . GLY A 1 318 ? 47.987 11.579 11.863 1.00 13.13 ? 318 GLY A CA 1 ATOM 2446 C C . GLY A 1 318 ? 47.444 11.025 13.175 1.00 13.28 ? 318 GLY A C 1 ATOM 2447 O O . GLY A 1 318 ? 47.664 9.849 13.502 1.00 12.36 ? 318 GLY A O 1 ATOM 2448 N N . HIS A 1 319 ? 46.696 11.856 13.910 1.00 13.19 ? 319 HIS A N 1 ATOM 2449 C CA . HIS A 1 319 ? 46.089 11.417 15.180 1.00 12.73 ? 319 HIS A CA 1 ATOM 2450 C C . HIS A 1 319 ? 45.070 10.272 15.004 1.00 13.18 ? 319 HIS A C 1 ATOM 2451 O O . HIS A 1 319 ? 45.073 9.337 15.803 1.00 13.59 ? 319 HIS A O 1 ATOM 2452 C CB . HIS A 1 319 ? 45.440 12.595 15.924 1.00 13.00 ? 319 HIS A CB 1 ATOM 2453 C CG . HIS A 1 319 ? 46.411 13.452 16.675 1.00 12.45 ? 319 HIS A CG 1 ATOM 2454 N ND1 . HIS A 1 319 ? 47.515 12.936 17.321 1.00 12.51 ? 319 HIS A ND1 1 ATOM 2455 C CD2 . HIS A 1 319 ? 46.437 14.786 16.898 1.00 11.80 ? 319 HIS A CD2 1 ATOM 2456 C CE1 . HIS A 1 319 ? 48.176 13.915 17.911 1.00 12.82 ? 319 HIS A CE1 1 ATOM 2457 N NE2 . HIS A 1 319 ? 47.542 15.047 17.673 1.00 12.39 ? 319 HIS A NE2 1 ATOM 2458 N N . HIS A 1 320 ? 44.233 10.339 13.964 1.00 13.56 ? 320 HIS A N 1 ATOM 2459 C CA . HIS A 1 320 ? 43.253 9.273 13.652 1.00 14.17 ? 320 HIS A CA 1 ATOM 2460 C C . HIS A 1 320 ? 43.921 7.922 13.422 1.00 14.49 ? 320 HIS A C 1 ATOM 2461 O O . HIS A 1 320 ? 43.366 6.875 13.761 1.00 15.23 ? 320 HIS A O 1 ATOM 2462 C CB . HIS A 1 320 ? 42.417 9.633 12.411 1.00 14.40 ? 320 HIS A CB 1 ATOM 2463 C CG . HIS A 1 320 ? 41.360 10.664 12.664 1.00 14.40 ? 320 HIS A CG 1 ATOM 2464 N ND1 . HIS A 1 320 ? 40.403 10.521 13.641 1.00 15.37 ? 320 HIS A ND1 1 ATOM 2465 C CD2 . HIS A 1 320 ? 41.116 11.859 12.069 1.00 14.90 ? 320 HIS A CD2 1 ATOM 2466 C CE1 . HIS A 1 320 ? 39.609 11.576 13.637 1.00 14.85 ? 320 HIS A CE1 1 ATOM 2467 N NE2 . HIS A 1 320 ? 40.027 12.411 12.700 1.00 14.55 ? 320 HIS A NE2 1 ATOM 2468 N N . GLU A 1 321 ? 45.118 7.952 12.847 1.00 15.29 ? 321 GLU A N 1 ATOM 2469 C CA . GLU A 1 321 ? 45.920 6.745 12.664 1.00 15.60 ? 321 GLU A CA 1 ATOM 2470 C C . GLU A 1 321 ? 46.654 6.356 13.950 1.00 15.79 ? 321 GLU A C 1 ATOM 2471 O O . GLU A 1 321 ? 47.285 5.301 14.015 1.00 15.53 ? 321 GLU A O 1 ATOM 2472 C CB . GLU A 1 321 ? 46.943 6.965 11.548 1.00 15.69 ? 321 GLU A CB 1 ATOM 2473 C CG . GLU A 1 321 ? 46.342 7.229 10.178 1.00 16.19 ? 321 GLU A CG 1 ATOM 2474 C CD . GLU A 1 321 ? 47.382 7.605 9.148 1.00 16.96 ? 321 GLU A CD 1 ATOM 2475 O OE1 . GLU A 1 321 ? 48.585 7.455 9.427 1.00 18.36 ? 321 GLU A OE1 1 ATOM 2476 O OE2 . GLU A 1 321 ? 46.995 8.049 8.051 1.00 20.00 ? 321 GLU A OE2 1 ATOM 2477 N N . SER A 1 322 ? 46.548 7.206 14.972 1.00 16.27 ? 322 SER A N 1 ATOM 2478 C CA . SER A 1 322 ? 47.346 7.120 16.186 1.00 16.39 ? 322 SER A CA 1 ATOM 2479 C C . SER A 1 322 ? 48.838 7.029 15.882 1.00 16.52 ? 322 SER A C 1 ATOM 2480 O O . SER A 1 322 ? 49.573 6.328 16.574 1.00 16.61 ? 322 SER A O 1 ATOM 2481 C CB . SER A 1 322 ? 46.870 5.984 17.096 1.00 16.61 ? 322 SER A CB 1 ATOM 2482 O OG . SER A 1 322 ? 45.623 6.335 17.695 1.00 16.95 ? 322 SER A OG 1 ATOM 2483 N N . ARG A 1 323 ? 49.266 7.783 14.863 1.00 16.28 ? 323 ARG A N 1 ATOM 2484 C CA . ARG A 1 323 ? 50.676 7.948 14.528 1.00 15.90 ? 323 ARG A CA 1 ATOM 2485 C C . ARG A 1 323 ? 51.086 9.379 14.847 1.00 15.38 ? 323 ARG A C 1 ATOM 2486 O O . ARG A 1 323 ? 51.047 10.259 13.987 1.00 14.16 ? 323 ARG A O 1 ATOM 2487 C CB . ARG A 1 323 ? 50.922 7.640 13.054 1.00 15.77 ? 323 ARG A CB 1 ATOM 2488 C CG . ARG A 1 323 ? 50.575 6.213 12.664 1.00 15.74 ? 323 ARG A CG 1 ATOM 2489 C CD . ARG A 1 323 ? 51.073 5.863 11.272 1.00 17.56 ? 323 ARG A CD 1 ATOM 2490 N NE . ARG A 1 323 ? 51.037 4.430 11.015 1.00 17.66 ? 323 ARG A NE 1 ATOM 2491 C CZ . ARG A 1 323 ? 50.221 3.827 10.163 1.00 20.50 ? 323 ARG A CZ 1 ATOM 2492 N NH1 . ARG A 1 323 ? 49.306 4.503 9.488 1.00 19.10 ? 323 ARG A NH1 1 ATOM 2493 N NH2 . ARG A 1 323 ? 50.306 2.510 10.004 1.00 20.69 ? 323 ARG A NH2 1 ATOM 2494 N N . ALA A 1 324 ? 51.474 9.594 16.102 1.00 15.21 ? 324 ALA A N 1 ATOM 2495 C CA . ALA A 1 324 ? 51.838 10.912 16.581 1.00 15.26 ? 324 ALA A CA 1 ATOM 2496 C C . ALA A 1 324 ? 52.973 11.507 15.762 1.00 14.92 ? 324 ALA A C 1 ATOM 2497 O O . ALA A 1 324 ? 53.064 12.712 15.629 1.00 14.00 ? 324 ALA A O 1 ATOM 2498 C CB . ALA A 1 324 ? 52.199 10.862 18.057 1.00 15.27 ? 324 ALA A CB 1 ATOM 2499 N N . TYR A 1 325 ? 53.841 10.663 15.211 1.00 15.59 ? 325 TYR A N 1 ATOM 2500 C CA . TYR A 1 325 ? 54.925 11.155 14.376 1.00 16.20 ? 325 TYR A CA 1 ATOM 2501 C C . TYR A 1 325 ? 54.373 11.938 13.195 1.00 15.26 ? 325 TYR A C 1 ATOM 2502 O O . TYR A 1 325 ? 54.873 12.998 12.868 1.00 15.11 ? 325 TYR A O 1 ATOM 2503 C CB . TYR A 1 325 ? 55.787 10.007 13.867 1.00 17.19 ? 325 TYR A CB 1 ATOM 2504 C CG . TYR A 1 325 ? 57.092 10.447 13.266 1.00 18.08 ? 325 TYR A CG 1 ATOM 2505 C CD1 . TYR A 1 325 ? 57.174 10.835 11.932 1.00 19.14 ? 325 TYR A CD1 1 ATOM 2506 C CD2 . TYR A 1 325 ? 58.253 10.433 14.023 1.00 19.77 ? 325 TYR A CD2 1 ATOM 2507 C CE1 . TYR A 1 325 ? 58.377 11.220 11.370 1.00 20.03 ? 325 TYR A CE1 1 ATOM 2508 C CE2 . TYR A 1 325 ? 59.461 10.817 13.482 1.00 20.64 ? 325 TYR A CE2 1 ATOM 2509 C CZ . TYR A 1 325 ? 59.518 11.205 12.153 1.00 20.54 ? 325 TYR A CZ 1 ATOM 2510 O OH . TYR A 1 325 ? 60.720 11.577 11.606 1.00 21.27 ? 325 TYR A OH 1 ATOM 2511 N N . ARG A 1 326 ? 53.321 11.419 12.579 1.00 14.64 ? 326 ARG A N 1 ATOM 2512 C CA . ARG A 1 326 ? 52.676 12.115 11.466 1.00 14.52 ? 326 ARG A CA 1 ATOM 2513 C C . ARG A 1 326 ? 51.899 13.329 11.962 1.00 14.28 ? 326 ARG A C 1 ATOM 2514 O O . ARG A 1 326 ? 52.024 14.395 11.399 1.00 14.52 ? 326 ARG A O 1 ATOM 2515 C CB . ARG A 1 326 ? 51.755 11.178 10.716 1.00 14.49 ? 326 ARG A CB 1 ATOM 2516 C CG . ARG A 1 326 ? 52.492 10.116 10.035 1.00 16.35 ? 326 ARG A CG 1 ATOM 2517 C CD . ARG A 1 326 ? 51.617 9.086 9.426 1.00 18.36 ? 326 ARG A CD 1 ATOM 2518 N NE . ARG A 1 326 ? 52.428 8.005 8.881 1.00 18.61 ? 326 ARG A NE 1 ATOM 2519 C CZ . ARG A 1 326 ? 52.003 7.158 7.959 1.00 19.28 ? 326 ARG A CZ 1 ATOM 2520 N NH1 . ARG A 1 326 ? 52.803 6.197 7.504 1.00 20.87 ? 326 ARG A NH1 1 ATOM 2521 N NH2 . ARG A 1 326 ? 50.781 7.265 7.488 1.00 17.77 ? 326 ARG A NH2 1 ATOM 2522 N N . ALA A 1 327 ? 51.145 13.182 13.047 1.00 14.61 ? 327 ALA A N 1 ATOM 2523 C CA . ALA A 1 327 ? 50.410 14.341 13.616 1.00 14.51 ? 327 ALA A CA 1 ATOM 2524 C C . ALA A 1 327 ? 51.343 15.518 13.938 1.00 14.09 ? 327 ALA A C 1 ATOM 2525 O O . ALA A 1 327 ? 51.051 16.671 13.614 1.00 14.08 ? 327 ALA A O 1 ATOM 2526 C CB . ALA A 1 327 ? 49.637 13.928 14.851 1.00 14.23 ? 327 ALA A CB 1 ATOM 2527 N N . LEU A 1 328 ? 52.463 15.223 14.584 1.00 13.83 ? 328 LEU A N 1 ATOM 2528 C CA . LEU A 1 328 ? 53.371 16.279 15.047 1.00 13.68 ? 328 LEU A CA 1 ATOM 2529 C C . LEU A 1 328 ? 54.225 16.855 13.936 1.00 13.87 ? 328 LEU A C 1 ATOM 2530 O O . LEU A 1 328 ? 54.462 18.071 13.922 1.00 14.01 ? 328 LEU A O 1 ATOM 2531 C CB . LEU A 1 328 ? 54.254 15.805 16.204 1.00 13.18 ? 328 LEU A CB 1 ATOM 2532 C CG . LEU A 1 328 ? 53.539 15.248 17.430 1.00 13.62 ? 328 LEU A CG 1 ATOM 2533 C CD1 . LEU A 1 328 ? 54.540 14.964 18.531 1.00 12.66 ? 328 LEU A CD1 1 ATOM 2534 C CD2 . LEU A 1 328 ? 52.454 16.194 17.918 1.00 14.41 ? 328 LEU A CD2 1 ATOM 2535 N N . THR A 1 329 ? 54.665 16.030 12.990 1.00 13.93 ? 329 THR A N 1 ATOM 2536 C CA . THR A 1 329 ? 55.384 16.581 11.833 1.00 14.77 ? 329 THR A CA 1 ATOM 2537 C C . THR A 1 329 ? 54.471 17.456 10.993 1.00 14.00 ? 329 THR A C 1 ATOM 2538 O O . THR A 1 329 ? 54.902 18.476 10.503 1.00 14.11 ? 329 THR A O 1 ATOM 2539 C CB . THR A 1 329 ? 56.072 15.504 10.962 1.00 14.54 ? 329 THR A CB 1 ATOM 2540 O OG1 . THR A 1 329 ? 55.152 14.459 10.636 1.00 15.61 ? 329 THR A OG1 1 ATOM 2541 C CG2 . THR A 1 329 ? 57.203 14.806 11.737 1.00 16.62 ? 329 THR A CG2 1 ATOM 2542 N N . GLU A 1 330 ? 53.196 17.107 10.873 1.00 14.10 ? 330 GLU A N 1 ATOM 2543 C CA . GLU A 1 330 ? 52.251 18.014 10.195 1.00 13.73 ? 330 GLU A CA 1 ATOM 2544 C C . GLU A 1 330 ? 52.088 19.325 10.962 1.00 13.70 ? 330 GLU A C 1 ATOM 2545 O O . GLU A 1 330 ? 51.960 20.405 10.353 1.00 13.55 ? 330 GLU A O 1 ATOM 2546 C CB . GLU A 1 330 ? 50.884 17.349 10.016 1.00 14.08 ? 330 GLU A CB 1 ATOM 2547 C CG . GLU A 1 330 ? 50.896 16.164 9.062 1.00 14.07 ? 330 GLU A CG 1 ATOM 2548 C CD . GLU A 1 330 ? 51.343 16.534 7.665 1.00 15.08 ? 330 GLU A CD 1 ATOM 2549 O OE1 . GLU A 1 330 ? 52.413 16.046 7.244 1.00 16.39 ? 330 GLU A OE1 1 ATOM 2550 O OE2 . GLU A 1 330 ? 50.627 17.303 6.979 1.00 15.44 ? 330 GLU A OE2 1 ATOM 2551 N N . THR A 1 331 ? 52.100 19.229 12.293 1.00 13.17 ? 331 THR A N 1 ATOM 2552 C CA . THR A 1 331 ? 51.933 20.400 13.133 1.00 12.97 ? 331 THR A CA 1 ATOM 2553 C C . THR A 1 331 ? 53.135 21.307 12.976 1.00 13.04 ? 331 THR A C 1 ATOM 2554 O O . THR A 1 331 ? 52.982 22.522 12.908 1.00 12.31 ? 331 THR A O 1 ATOM 2555 C CB . THR A 1 331 ? 51.730 20.033 14.624 1.00 13.55 ? 331 THR A CB 1 ATOM 2556 O OG1 . THR A 1 331 ? 50.649 19.095 14.773 1.00 12.51 ? 331 THR A OG1 1 ATOM 2557 C CG2 . THR A 1 331 ? 51.289 21.261 15.397 1.00 13.53 ? 331 THR A CG2 1 ATOM 2558 N N . ILE A 1 332 ? 54.342 20.742 12.887 1.00 13.35 ? 332 ILE A N 1 ATOM 2559 C CA . ILE A 1 332 ? 55.523 21.593 12.692 1.00 14.06 ? 332 ILE A CA 1 ATOM 2560 C C . ILE A 1 332 ? 55.466 22.327 11.351 1.00 14.13 ? 332 ILE A C 1 ATOM 2561 O O . ILE A 1 332 ? 55.754 23.520 11.289 1.00 14.14 ? 332 ILE A O 1 ATOM 2562 C CB . ILE A 1 332 ? 56.828 20.797 12.836 1.00 14.25 ? 332 ILE A CB 1 ATOM 2563 C CG1 . ILE A 1 332 ? 57.011 20.371 14.298 1.00 15.22 ? 332 ILE A CG1 1 ATOM 2564 C CG2 . ILE A 1 332 ? 58.037 21.636 12.400 1.00 14.88 ? 332 ILE A CG2 1 ATOM 2565 C CD1 . ILE A 1 332 ? 58.143 19.343 14.502 1.00 15.41 ? 332 ILE A CD1 1 ATOM 2566 N N . MET A 1 333 ? 55.084 21.622 10.289 1.00 13.79 ? 333 MET A N 1 ATOM 2567 C CA . MET A 1 333 ? 54.957 22.257 8.983 1.00 13.79 ? 333 MET A CA 1 ATOM 2568 C C . MET A 1 333 ? 53.872 23.346 9.011 1.00 13.67 ? 333 MET A C 1 ATOM 2569 O O . MET A 1 333 ? 54.042 24.385 8.403 1.00 13.64 ? 333 MET A O 1 ATOM 2570 C CB . MET A 1 333 ? 54.693 21.223 7.884 1.00 13.73 ? 333 MET A CB 1 ATOM 2571 C CG . MET A 1 333 ? 54.350 21.831 6.503 1.00 15.28 ? 333 MET A CG 1 ATOM 2572 S SD . MET A 1 333 ? 55.539 23.051 5.894 1.00 17.60 ? 333 MET A SD 1 ATOM 2573 C CE . MET A 1 333 ? 56.947 22.040 5.467 1.00 17.91 ? 333 MET A CE 1 ATOM 2574 N N . PHE A 1 334 ? 52.787 23.091 9.736 1.00 13.30 ? 334 PHE A N 1 ATOM 2575 C CA . PHE A 1 334 ? 51.736 24.078 9.959 1.00 13.86 ? 334 PHE A CA 1 ATOM 2576 C C . PHE A 1 334 ? 52.309 25.307 10.649 1.00 13.32 ? 334 PHE A C 1 ATOM 2577 O O . PHE A 1 334 ? 52.063 26.435 10.239 1.00 12.69 ? 334 PHE A O 1 ATOM 2578 C CB . PHE A 1 334 ? 50.604 23.438 10.785 1.00 13.76 ? 334 PHE A CB 1 ATOM 2579 C CG . PHE A 1 334 ? 49.495 24.380 11.171 1.00 14.10 ? 334 PHE A CG 1 ATOM 2580 C CD1 . PHE A 1 334 ? 48.732 25.031 10.202 1.00 14.84 ? 334 PHE A CD1 1 ATOM 2581 C CD2 . PHE A 1 334 ? 49.176 24.583 12.514 1.00 14.22 ? 334 PHE A CD2 1 ATOM 2582 C CE1 . PHE A 1 334 ? 47.693 25.883 10.580 1.00 14.06 ? 334 PHE A CE1 1 ATOM 2583 C CE2 . PHE A 1 334 ? 48.138 25.429 12.881 1.00 13.43 ? 334 PHE A CE2 1 ATOM 2584 C CZ . PHE A 1 334 ? 47.410 26.081 11.924 1.00 13.10 ? 334 PHE A CZ 1 ATOM 2585 N N . ASP A 1 335 ? 53.089 25.083 11.700 1.00 14.08 ? 335 ASP A N 1 ATOM 2586 C CA . ASP A 1 335 ? 53.754 26.178 12.380 1.00 14.10 ? 335 ASP A CA 1 ATOM 2587 C C . ASP A 1 335 ? 54.742 26.924 11.481 1.00 14.19 ? 335 ASP A C 1 ATOM 2588 O O . ASP A 1 335 ? 54.867 28.143 11.580 1.00 13.34 ? 335 ASP A O 1 ATOM 2589 C CB . ASP A 1 335 ? 54.462 25.689 13.637 1.00 14.34 ? 335 ASP A CB 1 ATOM 2590 C CG . ASP A 1 335 ? 54.891 26.827 14.533 1.00 15.10 ? 335 ASP A CG 1 ATOM 2591 O OD1 . ASP A 1 335 ? 54.004 27.569 15.021 1.00 15.84 ? 335 ASP A OD1 1 ATOM 2592 O OD2 . ASP A 1 335 ? 56.093 27.070 14.793 1.00 15.02 ? 335 ASP A OD2 1 ATOM 2593 N N . ASP A 1 336 ? 55.444 26.201 10.612 1.00 14.21 ? 336 ASP A N 1 ATOM 2594 C CA . ASP A 1 336 ? 56.362 26.845 9.654 1.00 14.19 ? 336 ASP A CA 1 ATOM 2595 C C . ASP A 1 336 ? 55.625 27.746 8.677 1.00 14.07 ? 336 ASP A C 1 ATOM 2596 O O . ASP A 1 336 ? 56.135 28.809 8.282 1.00 13.57 ? 336 ASP A O 1 ATOM 2597 C CB . ASP A 1 336 ? 57.158 25.811 8.861 1.00 14.30 ? 336 ASP A CB 1 ATOM 2598 C CG . ASP A 1 336 ? 58.170 25.037 9.720 1.00 14.93 ? 336 ASP A CG 1 ATOM 2599 O OD1 . ASP A 1 336 ? 58.570 25.496 10.812 1.00 14.04 ? 336 ASP A OD1 1 ATOM 2600 O OD2 . ASP A 1 336 ? 58.615 23.932 9.356 1.00 13.84 ? 336 ASP A OD2 1 ATOM 2601 N N . ALA A 1 337 ? 54.432 27.318 8.276 1.00 13.83 ? 337 ALA A N 1 ATOM 2602 C CA . ALA A 1 337 ? 53.594 28.098 7.379 1.00 13.71 ? 337 ALA A CA 1 ATOM 2603 C C . ALA A 1 337 ? 53.115 29.360 8.085 1.00 14.13 ? 337 ALA A C 1 ATOM 2604 O O . ALA A 1 337 ? 53.103 30.441 7.502 1.00 14.18 ? 337 ALA A O 1 ATOM 2605 C CB . ALA A 1 337 ? 52.397 27.259 6.896 1.00 13.83 ? 337 ALA A CB 1 ATOM 2606 N N . ILE A 1 338 ? 52.740 29.222 9.360 1.00 14.59 ? 338 ILE A N 1 ATOM 2607 C CA . ILE A 1 338 ? 52.364 30.377 10.172 1.00 14.27 ? 338 ILE A CA 1 ATOM 2608 C C . ILE A 1 338 ? 53.540 31.365 10.251 1.00 14.24 ? 338 ILE A C 1 ATOM 2609 O O . ILE A 1 338 ? 53.359 32.575 10.110 1.00 12.62 ? 338 ILE A O 1 ATOM 2610 C CB . ILE A 1 338 ? 51.975 29.915 11.585 1.00 14.44 ? 338 ILE A CB 1 ATOM 2611 C CG1 . ILE A 1 338 ? 50.663 29.118 11.549 1.00 14.44 ? 338 ILE A CG1 1 ATOM 2612 C CG2 . ILE A 1 338 ? 51.855 31.115 12.524 1.00 15.17 ? 338 ILE A CG2 1 ATOM 2613 C CD1 . ILE A 1 338 ? 50.384 28.356 12.852 1.00 14.79 ? 338 ILE A CD1 1 ATOM 2614 N N . GLU A 1 339 ? 54.735 30.830 10.492 1.00 14.24 ? 339 GLU A N 1 ATOM 2615 C CA . GLU A 1 339 ? 55.940 31.650 10.589 1.00 14.66 ? 339 GLU A CA 1 ATOM 2616 C C . GLU A 1 339 ? 56.188 32.389 9.289 1.00 14.71 ? 339 GLU A C 1 ATOM 2617 O O . GLU A 1 339 ? 56.483 33.584 9.293 1.00 13.62 ? 339 GLU A O 1 ATOM 2618 C CB . GLU A 1 339 ? 57.136 30.774 10.920 1.00 14.76 ? 339 GLU A CB 1 ATOM 2619 C CG . GLU A 1 339 ? 58.432 31.506 11.197 1.00 16.34 ? 339 GLU A CG 1 ATOM 2620 C CD . GLU A 1 339 ? 59.503 30.540 11.642 1.00 18.67 ? 339 GLU A CD 1 ATOM 2621 O OE1 . GLU A 1 339 ? 59.947 30.647 12.808 1.00 23.04 ? 339 GLU A OE1 1 ATOM 2622 O OE2 . GLU A 1 339 ? 59.862 29.660 10.841 1.00 19.61 ? 339 GLU A OE2 1 ATOM 2623 N N . ARG A 1 340 ? 56.068 31.666 8.182 1.00 14.33 ? 340 ARG A N 1 ATOM 2624 C CA . ARG A 1 340 ? 56.261 32.255 6.849 1.00 14.56 ? 340 ARG A CA 1 ATOM 2625 C C . ARG A 1 340 ? 55.240 33.356 6.517 1.00 14.64 ? 340 ARG A C 1 ATOM 2626 O O . ARG A 1 340 ? 55.603 34.461 6.052 1.00 14.88 ? 340 ARG A O 1 ATOM 2627 C CB . ARG A 1 340 ? 56.242 31.146 5.787 1.00 14.72 ? 340 ARG A CB 1 ATOM 2628 C CG . ARG A 1 340 ? 56.692 31.566 4.412 1.00 15.28 ? 340 ARG A CG 1 ATOM 2629 C CD . ARG A 1 340 ? 57.949 32.410 4.464 1.00 17.19 ? 340 ARG A CD 1 ATOM 2630 N NE . ARG A 1 340 ? 58.342 32.916 3.163 1.00 18.40 ? 340 ARG A NE 1 ATOM 2631 C CZ . ARG A 1 340 ? 59.303 33.822 2.995 1.00 18.73 ? 340 ARG A CZ 1 ATOM 2632 N NH1 . ARG A 1 340 ? 59.948 34.317 4.038 1.00 18.04 ? 340 ARG A NH1 1 ATOM 2633 N NH2 . ARG A 1 340 ? 59.603 34.254 1.787 1.00 18.26 ? 340 ARG A NH2 1 ATOM 2634 N N . ALA A 1 341 ? 53.965 33.090 6.774 1.00 15.08 ? 341 ALA A N 1 ATOM 2635 C CA . ALA A 1 341 ? 52.938 34.120 6.579 1.00 14.85 ? 341 ALA A CA 1 ATOM 2636 C C . ALA A 1 341 ? 53.264 35.366 7.398 1.00 15.28 ? 341 ALA A C 1 ATOM 2637 O O . ALA A 1 341 ? 53.105 36.483 6.910 1.00 15.43 ? 341 ALA A O 1 ATOM 2638 C CB . ALA A 1 341 ? 51.561 33.592 6.933 1.00 15.21 ? 341 ALA A CB 1 ATOM 2639 N N . GLY A 1 342 ? 53.740 35.173 8.633 1.00 15.55 ? 342 GLY A N 1 ATOM 2640 C CA . GLY A 1 342 ? 54.185 36.288 9.488 1.00 15.62 ? 342 GLY A CA 1 ATOM 2641 C C . GLY A 1 342 ? 55.316 37.075 8.867 1.00 15.93 ? 342 GLY A C 1 ATOM 2642 O O . GLY A 1 342 ? 55.400 38.297 9.039 1.00 16.68 ? 342 GLY A O 1 ATOM 2643 N N . GLN A 1 343 ? 56.180 36.394 8.118 1.00 16.57 ? 343 GLN A N 1 ATOM 2644 C CA . GLN A 1 343 ? 57.295 37.088 7.434 1.00 16.67 ? 343 GLN A CA 1 ATOM 2645 C C . GLN A 1 343 ? 56.828 37.884 6.229 1.00 16.67 ? 343 GLN A C 1 ATOM 2646 O O . GLN A 1 343 ? 57.445 38.886 5.868 1.00 17.52 ? 343 GLN A O 1 ATOM 2647 C CB . GLN A 1 343 ? 58.360 36.101 7.008 1.00 15.94 ? 343 GLN A CB 1 ATOM 2648 C CG . GLN A 1 343 ? 59.156 35.559 8.148 1.00 17.56 ? 343 GLN A CG 1 ATOM 2649 C CD . GLN A 1 343 ? 60.112 34.490 7.706 1.00 19.36 ? 343 GLN A CD 1 ATOM 2650 O OE1 . GLN A 1 343 ? 59.720 33.577 6.984 1.00 19.55 ? 343 GLN A OE1 1 ATOM 2651 N NE2 . GLN A 1 343 ? 61.368 34.603 8.113 1.00 19.43 ? 343 GLN A NE2 1 ATOM 2652 N N . LEU A 1 344 ? 55.726 37.449 5.626 1.00 16.80 ? 344 LEU A N 1 ATOM 2653 C CA . LEU A 1 344 ? 55.239 38.034 4.390 1.00 16.83 ? 344 LEU A CA 1 ATOM 2654 C C . LEU A 1 344 ? 54.092 39.036 4.579 1.00 17.29 ? 344 LEU A C 1 ATOM 2655 O O . LEU A 1 344 ? 53.650 39.655 3.611 1.00 17.50 ? 344 LEU A O 1 ATOM 2656 C CB . LEU A 1 344 ? 54.785 36.911 3.459 1.00 16.96 ? 344 LEU A CB 1 ATOM 2657 C CG . LEU A 1 344 ? 55.898 35.992 2.939 1.00 16.40 ? 344 LEU A CG 1 ATOM 2658 C CD1 . LEU A 1 344 ? 55.262 34.916 2.129 1.00 17.40 ? 344 LEU A CD1 1 ATOM 2659 C CD2 . LEU A 1 344 ? 56.933 36.747 2.122 1.00 17.06 ? 344 LEU A CD2 1 ATOM 2660 N N . THR A 1 345 ? 53.600 39.187 5.808 1.00 16.99 ? 345 THR A N 1 ATOM 2661 C CA . THR A 1 345 ? 52.524 40.139 6.109 1.00 17.26 ? 345 THR A CA 1 ATOM 2662 C C . THR A 1 345 ? 52.882 40.962 7.327 1.00 17.99 ? 345 THR A C 1 ATOM 2663 O O . THR A 1 345 ? 53.762 40.572 8.095 1.00 17.90 ? 345 THR A O 1 ATOM 2664 C CB . THR A 1 345 ? 51.212 39.385 6.359 1.00 16.63 ? 345 THR A CB 1 ATOM 2665 O OG1 . THR A 1 345 ? 51.377 38.487 7.461 1.00 17.00 ? 345 THR A OG1 1 ATOM 2666 C CG2 . THR A 1 345 ? 50.877 38.479 5.188 1.00 15.94 ? 345 THR A CG2 1 ATOM 2667 N N . SER A 1 346 ? 52.189 42.090 7.513 1.00 18.39 ? 346 SER A N 1 ATOM 2668 C CA . SER A 1 346 ? 52.421 42.972 8.658 1.00 18.67 ? 346 SER A CA 1 ATOM 2669 C C . SER A 1 346 ? 51.303 42.861 9.692 1.00 18.99 ? 346 SER A C 1 ATOM 2670 O O . SER A 1 346 ? 50.130 42.892 9.350 1.00 18.60 ? 346 SER A O 1 ATOM 2671 C CB . SER A 1 346 ? 52.540 44.422 8.187 1.00 19.22 ? 346 SER A CB 1 ATOM 2672 O OG . SER A 1 346 ? 52.664 45.319 9.289 1.00 19.18 ? 346 SER A OG 1 ATOM 2673 N N . GLU A 1 347 ? 51.663 42.740 10.967 1.00 19.35 ? 347 GLU A N 1 ATOM 2674 C CA . GLU A 1 347 ? 50.647 42.718 12.017 1.00 20.41 ? 347 GLU A CA 1 ATOM 2675 C C . GLU A 1 347 ? 50.012 44.100 12.252 1.00 20.18 ? 347 GLU A C 1 ATOM 2676 O O . GLU A 1 347 ? 49.027 44.221 12.983 1.00 20.08 ? 347 GLU A O 1 ATOM 2677 C CB . GLU A 1 347 ? 51.186 42.123 13.317 1.00 20.75 ? 347 GLU A CB 1 ATOM 2678 C CG . GLU A 1 347 ? 52.328 42.888 13.939 1.00 21.66 ? 347 GLU A CG 1 ATOM 2679 C CD . GLU A 1 347 ? 52.715 42.394 15.315 1.00 22.80 ? 347 GLU A CD 1 ATOM 2680 O OE1 . GLU A 1 347 ? 51.927 41.679 15.979 1.00 28.18 ? 347 GLU A OE1 1 ATOM 2681 O OE2 . GLU A 1 347 ? 53.821 42.754 15.751 1.00 28.33 ? 347 GLU A OE2 1 ATOM 2682 N N . GLU A 1 348 ? 50.568 45.134 11.619 1.00 20.25 ? 348 GLU A N 1 ATOM 2683 C CA . GLU A 1 348 ? 49.935 46.448 11.588 1.00 20.34 ? 348 GLU A CA 1 ATOM 2684 C C . GLU A 1 348 ? 48.597 46.460 10.868 1.00 19.42 ? 348 GLU A C 1 ATOM 2685 O O . GLU A 1 348 ? 47.711 47.237 11.225 1.00 19.18 ? 348 GLU A O 1 ATOM 2686 C CB . GLU A 1 348 ? 50.861 47.473 10.935 1.00 20.64 ? 348 GLU A CB 1 ATOM 2687 C CG . GLU A 1 348 ? 52.180 47.653 11.667 1.00 23.50 ? 348 GLU A CG 1 ATOM 2688 C CD . GLU A 1 348 ? 52.000 47.840 13.163 1.00 27.25 ? 348 GLU A CD 1 ATOM 2689 O OE1 . GLU A 1 348 ? 51.186 48.704 13.582 1.00 30.37 ? 348 GLU A OE1 1 ATOM 2690 O OE2 . GLU A 1 348 ? 52.679 47.129 13.934 1.00 32.10 ? 348 GLU A OE2 1 ATOM 2691 N N . ASP A 1 349 ? 48.453 45.620 9.850 1.00 18.80 ? 349 ASP A N 1 ATOM 2692 C CA . ASP A 1 349 ? 47.219 45.594 9.055 1.00 17.81 ? 349 ASP A CA 1 ATOM 2693 C C . ASP A 1 349 ? 46.612 44.200 8.820 1.00 17.06 ? 349 ASP A C 1 ATOM 2694 O O . ASP A 1 349 ? 45.584 44.083 8.130 1.00 16.26 ? 349 ASP A O 1 ATOM 2695 C CB . ASP A 1 349 ? 47.424 46.339 7.726 1.00 17.93 ? 349 ASP A CB 1 ATOM 2696 C CG . ASP A 1 349 ? 48.311 45.598 6.742 1.00 19.26 ? 349 ASP A CG 1 ATOM 2697 O OD1 . ASP A 1 349 ? 48.463 46.115 5.619 1.00 18.98 ? 349 ASP A OD1 1 ATOM 2698 O OD2 . ASP A 1 349 ? 48.904 44.522 6.985 1.00 20.20 ? 349 ASP A OD2 1 ATOM 2699 N N . THR A 1 350 ? 47.231 43.169 9.398 1.00 15.94 ? 350 THR A N 1 ATOM 2700 C CA . THR A 1 350 ? 46.793 41.776 9.196 1.00 15.59 ? 350 THR A CA 1 ATOM 2701 C C . THR A 1 350 ? 46.422 41.130 10.516 1.00 15.69 ? 350 THR A C 1 ATOM 2702 O O . THR A 1 350 ? 47.270 41.011 11.399 1.00 15.94 ? 350 THR A O 1 ATOM 2703 C CB . THR A 1 350 ? 47.919 40.959 8.566 1.00 15.12 ? 350 THR A CB 1 ATOM 2704 O OG1 . THR A 1 350 ? 48.316 41.571 7.333 1.00 15.10 ? 350 THR A OG1 1 ATOM 2705 C CG2 . THR A 1 350 ? 47.458 39.548 8.179 1.00 14.29 ? 350 THR A CG2 1 ATOM 2706 N N . LEU A 1 351 ? 45.159 40.735 10.662 1.00 15.16 ? 351 LEU A N 1 ATOM 2707 C CA . LEU A 1 351 ? 44.729 39.974 11.827 1.00 15.29 ? 351 LEU A CA 1 ATOM 2708 C C . LEU A 1 351 ? 44.926 38.502 11.527 1.00 15.27 ? 351 LEU A C 1 ATOM 2709 O O . LEU A 1 351 ? 44.315 37.974 10.597 1.00 15.56 ? 351 LEU A O 1 ATOM 2710 C CB . LEU A 1 351 ? 43.259 40.224 12.151 1.00 15.26 ? 351 LEU A CB 1 ATOM 2711 C CG . LEU A 1 351 ? 42.650 39.408 13.294 1.00 15.60 ? 351 LEU A CG 1 ATOM 2712 C CD1 . LEU A 1 351 ? 43.379 39.593 14.630 1.00 16.22 ? 351 LEU A CD1 1 ATOM 2713 C CD2 . LEU A 1 351 ? 41.173 39.752 13.471 1.00 16.01 ? 351 LEU A CD2 1 ATOM 2714 N N . SER A 1 352 ? 45.788 37.854 12.292 1.00 14.90 ? 352 SER A N 1 ATOM 2715 C CA . SER A 1 352 ? 46.076 36.442 12.100 1.00 15.08 ? 352 SER A CA 1 ATOM 2716 C C . SER A 1 352 ? 45.577 35.704 13.325 1.00 15.02 ? 352 SER A C 1 ATOM 2717 O O . SER A 1 352 ? 45.924 36.077 14.458 1.00 14.46 ? 352 SER A O 1 ATOM 2718 C CB . SER A 1 352 ? 47.580 36.215 11.953 1.00 15.09 ? 352 SER A CB 1 ATOM 2719 O OG . SER A 1 352 ? 48.111 36.899 10.840 1.00 17.14 ? 352 SER A OG 1 ATOM 2720 N N . LEU A 1 353 ? 44.754 34.677 13.107 1.00 14.45 ? 353 LEU A N 1 ATOM 2721 C CA . LEU A 1 353 ? 44.325 33.784 14.173 1.00 14.84 ? 353 LEU A CA 1 ATOM 2722 C C . LEU A 1 353 ? 44.807 32.376 13.862 1.00 14.01 ? 353 LEU A C 1 ATOM 2723 O O . LEU A 1 353 ? 44.678 31.911 12.737 1.00 13.76 ? 353 LEU A O 1 ATOM 2724 C CB . LEU A 1 353 ? 42.802 33.753 14.359 1.00 14.79 ? 353 LEU A CB 1 ATOM 2725 C CG . LEU A 1 353 ? 41.962 35.027 14.572 1.00 17.60 ? 353 LEU A CG 1 ATOM 2726 C CD1 . LEU A 1 353 ? 40.659 34.651 15.300 1.00 18.71 ? 353 LEU A CD1 1 ATOM 2727 C CD2 . LEU A 1 353 ? 42.686 36.097 15.303 1.00 19.39 ? 353 LEU A CD2 1 ATOM 2728 N N . VAL A 1 354 ? 45.407 31.726 14.847 1.00 13.81 ? 354 VAL A N 1 ATOM 2729 C CA . VAL A 1 354 ? 45.739 30.320 14.755 1.00 13.06 ? 354 VAL A CA 1 ATOM 2730 C C . VAL A 1 354 ? 44.810 29.615 15.703 1.00 12.92 ? 354 VAL A C 1 ATOM 2731 O O . VAL A 1 354 ? 44.658 30.035 16.853 1.00 12.50 ? 354 VAL A O 1 ATOM 2732 C CB . VAL A 1 354 ? 47.166 30.008 15.196 1.00 13.50 ? 354 VAL A CB 1 ATOM 2733 C CG1 . VAL A 1 354 ? 47.450 28.508 15.021 1.00 14.21 ? 354 VAL A CG1 1 ATOM 2734 C CG2 . VAL A 1 354 ? 48.164 30.844 14.428 1.00 13.25 ? 354 VAL A CG2 1 ATOM 2735 N N . THR A 1 355 ? 44.181 28.544 15.237 1.00 13.03 ? 355 THR A N 1 ATOM 2736 C CA . THR A 1 355 ? 43.360 27.754 16.131 1.00 13.17 ? 355 THR A CA 1 ATOM 2737 C C . THR A 1 355 ? 43.252 26.321 15.629 1.00 13.22 ? 355 THR A C 1 ATOM 2738 O O . THR A 1 355 ? 43.890 25.937 14.646 1.00 12.98 ? 355 THR A O 1 ATOM 2739 C CB . THR A 1 355 ? 41.978 28.437 16.317 1.00 13.42 ? 355 THR A CB 1 ATOM 2740 O OG1 . THR A 1 355 ? 41.332 27.952 17.499 1.00 12.89 ? 355 THR A OG1 1 ATOM 2741 C CG2 . THR A 1 355 ? 41.016 28.139 15.156 1.00 14.06 ? 355 THR A CG2 1 ATOM 2742 N N . ALA A 1 356 ? 42.467 25.532 16.343 1.00 12.91 ? 356 ALA A N 1 ATOM 2743 C CA . ALA A 1 356 ? 42.160 24.176 15.923 1.00 12.52 ? 356 ALA A CA 1 ATOM 2744 C C . ALA A 1 356 ? 40.659 24.044 15.859 1.00 12.62 ? 356 ALA A C 1 ATOM 2745 O O . ALA A 1 356 ? 39.955 24.738 16.580 1.00 12.81 ? 356 ALA A O 1 ATOM 2746 C CB . ALA A 1 356 ? 42.729 23.191 16.906 1.00 12.07 ? 356 ALA A CB 1 ATOM 2747 N N . ASP A 1 357 ? 40.164 23.136 15.025 1.00 12.46 ? 357 ASP A N 1 ATOM 2748 C CA . ASP A 1 357 ? 38.716 22.901 14.991 1.00 12.87 ? 357 ASP A CA 1 ATOM 2749 C C . ASP A 1 357 ? 38.236 22.124 16.221 1.00 12.32 ? 357 ASP A C 1 ATOM 2750 O O . ASP A 1 357 ? 37.125 22.342 16.710 1.00 13.32 ? 357 ASP A O 1 ATOM 2751 C CB . ASP A 1 357 ? 38.270 22.261 13.669 1.00 12.60 ? 357 ASP A CB 1 ATOM 2752 C CG . ASP A 1 357 ? 38.975 20.958 13.350 1.00 13.37 ? 357 ASP A CG 1 ATOM 2753 O OD1 . ASP A 1 357 ? 40.039 20.653 13.960 1.00 10.79 ? 357 ASP A OD1 1 ATOM 2754 O OD2 . ASP A 1 357 ? 38.498 20.160 12.492 1.00 12.72 ? 357 ASP A OD2 1 ATOM 2755 N N . HIS A 1 358 ? 39.104 21.257 16.729 1.00 11.66 ? 358 HIS A N 1 ATOM 2756 C CA . HIS A 1 358 ? 38.853 20.423 17.891 1.00 11.80 ? 358 HIS A CA 1 ATOM 2757 C C . HIS A 1 358 ? 40.156 19.724 18.168 1.00 11.98 ? 358 HIS A C 1 ATOM 2758 O O . HIS A 1 358 ? 41.121 19.836 17.396 1.00 12.27 ? 358 HIS A O 1 ATOM 2759 C CB . HIS A 1 358 ? 37.803 19.348 17.571 1.00 11.87 ? 358 HIS A CB 1 ATOM 2760 C CG . HIS A 1 358 ? 38.165 18.567 16.366 1.00 10.99 ? 358 HIS A CG 1 ATOM 2761 N ND1 . HIS A 1 358 ? 39.111 17.567 16.403 1.00 11.20 ? 358 HIS A ND1 1 ATOM 2762 C CD2 . HIS A 1 358 ? 37.833 18.735 15.063 1.00 12.23 ? 358 HIS A CD2 1 ATOM 2763 C CE1 . HIS A 1 358 ? 39.301 17.112 15.177 1.00 13.03 ? 358 HIS A CE1 1 ATOM 2764 N NE2 . HIS A 1 358 ? 38.528 17.791 14.348 1.00 12.15 ? 358 HIS A NE2 1 ATOM 2765 N N . SER A 1 359 ? 40.172 18.954 19.239 1.00 12.66 ? 359 SER A N 1 ATOM 2766 C CA . SER A 1 359 ? 41.349 18.235 19.648 1.00 12.56 ? 359 SER A CA 1 ATOM 2767 C C . SER A 1 359 ? 41.188 16.730 19.371 1.00 12.59 ? 359 SER A C 1 ATOM 2768 O O . SER A 1 359 ? 40.306 16.315 18.607 1.00 12.22 ? 359 SER A O 1 ATOM 2769 C CB . SER A 1 359 ? 41.594 18.497 21.133 1.00 13.09 ? 359 SER A CB 1 ATOM 2770 O OG . SER A 1 359 ? 42.794 17.875 21.572 1.00 13.16 ? 359 SER A OG 1 ATOM 2771 N N . HIS A 1 360 ? 42.083 15.946 19.980 1.00 12.51 ? 360 HIS A N 1 ATOM 2772 C CA . HIS A 1 360 ? 42.118 14.492 19.893 1.00 12.88 ? 360 HIS A CA 1 ATOM 2773 C C . HIS A 1 360 ? 42.405 13.922 21.269 1.00 13.18 ? 360 HIS A C 1 ATOM 2774 O O . HIS A 1 360 ? 42.856 14.642 22.163 1.00 13.88 ? 360 HIS A O 1 ATOM 2775 C CB . HIS A 1 360 ? 43.219 14.057 18.939 1.00 12.86 ? 360 HIS A CB 1 ATOM 2776 C CG . HIS A 1 360 ? 42.831 14.161 17.506 1.00 13.32 ? 360 HIS A CG 1 ATOM 2777 N ND1 . HIS A 1 360 ? 42.261 13.114 16.815 1.00 13.25 ? 360 HIS A ND1 1 ATOM 2778 C CD2 . HIS A 1 360 ? 42.871 15.204 16.650 1.00 13.38 ? 360 HIS A CD2 1 ATOM 2779 C CE1 . HIS A 1 360 ? 41.996 13.504 15.585 1.00 14.91 ? 360 HIS A CE1 1 ATOM 2780 N NE2 . HIS A 1 360 ? 42.360 14.768 15.458 1.00 11.92 ? 360 HIS A NE2 1 ATOM 2781 N N . VAL A 1 361 ? 42.146 12.634 21.436 1.00 12.84 ? 361 VAL A N 1 ATOM 2782 C CA . VAL A 1 361 ? 42.358 11.942 22.719 1.00 12.70 ? 361 VAL A CA 1 ATOM 2783 C C . VAL A 1 361 ? 43.841 11.583 22.929 1.00 12.77 ? 361 VAL A C 1 ATOM 2784 O O . VAL A 1 361 ? 44.164 10.527 23.458 1.00 12.83 ? 361 VAL A O 1 ATOM 2785 C CB . VAL A 1 361 ? 41.446 10.698 22.848 1.00 12.13 ? 361 VAL A CB 1 ATOM 2786 C CG1 . VAL A 1 361 ? 39.977 11.112 22.923 1.00 12.35 ? 361 VAL A CG1 1 ATOM 2787 C CG2 . VAL A 1 361 ? 41.621 9.757 21.719 1.00 13.08 ? 361 VAL A CG2 1 ATOM 2788 N N . PHE A 1 362 ? 44.710 12.516 22.536 1.00 12.77 ? 362 PHE A N 1 ATOM 2789 C CA . PHE A 1 362 ? 46.160 12.405 22.525 1.00 12.55 ? 362 PHE A CA 1 ATOM 2790 C C . PHE A 1 362 ? 46.742 12.922 23.841 1.00 12.95 ? 362 PHE A C 1 ATOM 2791 O O . PHE A 1 362 ? 46.422 14.031 24.268 1.00 13.40 ? 362 PHE A O 1 ATOM 2792 C CB . PHE A 1 362 ? 46.670 13.286 21.369 1.00 12.88 ? 362 PHE A CB 1 ATOM 2793 C CG . PHE A 1 362 ? 48.163 13.422 21.273 1.00 12.48 ? 362 PHE A CG 1 ATOM 2794 C CD1 . PHE A 1 362 ? 48.962 12.325 20.949 1.00 13.95 ? 362 PHE A CD1 1 ATOM 2795 C CD2 . PHE A 1 362 ? 48.770 14.661 21.417 1.00 13.78 ? 362 PHE A CD2 1 ATOM 2796 C CE1 . PHE A 1 362 ? 50.326 12.457 20.820 1.00 12.17 ? 362 PHE A CE1 1 ATOM 2797 C CE2 . PHE A 1 362 ? 50.141 14.805 21.291 1.00 11.92 ? 362 PHE A CE2 1 ATOM 2798 C CZ . PHE A 1 362 ? 50.926 13.693 20.998 1.00 14.15 ? 362 PHE A CZ 1 ATOM 2799 N N . SER A 1 363 ? 47.622 12.150 24.473 1.00 12.80 ? 363 SER A N 1 ATOM 2800 C CA . SER A 1 363 ? 48.224 12.615 25.728 1.00 13.00 ? 363 SER A CA 1 ATOM 2801 C C . SER A 1 363 ? 49.736 12.463 25.756 1.00 13.21 ? 363 SER A C 1 ATOM 2802 O O . SER A 1 363 ? 50.303 11.617 25.081 1.00 13.09 ? 363 SER A O 1 ATOM 2803 C CB . SER A 1 363 ? 47.605 11.913 26.928 1.00 12.77 ? 363 SER A CB 1 ATOM 2804 O OG . SER A 1 363 ? 47.880 10.516 26.917 1.00 12.52 ? 363 SER A OG 1 ATOM 2805 N N . PHE A 1 364 ? 50.357 13.300 26.574 1.00 13.25 ? 364 PHE A N 1 ATOM 2806 C CA . PHE A 1 364 ? 51.795 13.331 26.719 1.00 13.92 ? 364 PHE A CA 1 ATOM 2807 C C . PHE A 1 364 ? 52.093 13.166 28.206 1.00 13.82 ? 364 PHE A C 1 ATOM 2808 O O . PHE A 1 364 ? 51.851 14.084 28.986 1.00 14.01 ? 364 PHE A O 1 ATOM 2809 C CB . PHE A 1 364 ? 52.335 14.659 26.181 1.00 13.91 ? 364 PHE A CB 1 ATOM 2810 C CG . PHE A 1 364 ? 53.777 14.930 26.541 1.00 14.04 ? 364 PHE A CG 1 ATOM 2811 C CD1 . PHE A 1 364 ? 54.703 13.905 26.573 1.00 14.41 ? 364 PHE A CD1 1 ATOM 2812 C CD2 . PHE A 1 364 ? 54.204 16.210 26.810 1.00 15.47 ? 364 PHE A CD2 1 ATOM 2813 C CE1 . PHE A 1 364 ? 56.020 14.149 26.893 1.00 17.34 ? 364 PHE A CE1 1 ATOM 2814 C CE2 . PHE A 1 364 ? 55.533 16.457 27.132 1.00 14.68 ? 364 PHE A CE2 1 ATOM 2815 C CZ . PHE A 1 364 ? 56.425 15.436 27.175 1.00 15.79 ? 364 PHE A CZ 1 ATOM 2816 N N . GLY A 1 365 ? 52.565 11.981 28.585 1.00 14.56 ? 365 GLY A N 1 ATOM 2817 C CA . GLY A 1 365 ? 52.762 11.615 29.990 1.00 14.61 ? 365 GLY A CA 1 ATOM 2818 C C . GLY A 1 365 ? 54.018 10.783 30.238 1.00 14.98 ? 365 GLY A C 1 ATOM 2819 O O . GLY A 1 365 ? 55.012 10.929 29.543 1.00 15.43 ? 365 GLY A O 1 ATOM 2820 N N . GLY A 1 366 ? 53.954 9.877 31.213 1.00 15.60 ? 366 GLY A N 1 ATOM 2821 C CA . GLY A 1 366 ? 55.155 9.302 31.830 1.00 15.39 ? 366 GLY A CA 1 ATOM 2822 C C . GLY A 1 366 ? 55.892 10.457 32.477 1.00 15.71 ? 366 GLY A C 1 ATOM 2823 O O . GLY A 1 366 ? 55.361 11.562 32.574 1.00 17.09 ? 366 GLY A O 1 ATOM 2824 N N . TYR A 1 367 ? 57.125 10.231 32.881 1.00 15.85 ? 367 TYR A N 1 ATOM 2825 C CA . TYR A 1 367 ? 57.928 11.302 33.477 1.00 15.83 ? 367 TYR A CA 1 ATOM 2826 C C . TYR A 1 367 ? 59.280 11.352 32.784 1.00 16.02 ? 367 TYR A C 1 ATOM 2827 O O . TYR A 1 367 ? 60.315 11.162 33.442 1.00 16.76 ? 367 TYR A O 1 ATOM 2828 C CB . TYR A 1 367 ? 58.054 11.079 34.999 1.00 14.91 ? 367 TYR A CB 1 ATOM 2829 C CG . TYR A 1 367 ? 56.711 11.176 35.682 1.00 15.64 ? 367 TYR A CG 1 ATOM 2830 C CD1 . TYR A 1 367 ? 56.097 12.414 35.876 1.00 13.98 ? 367 TYR A CD1 1 ATOM 2831 C CD2 . TYR A 1 367 ? 56.043 10.039 36.126 1.00 14.83 ? 367 TYR A CD2 1 ATOM 2832 C CE1 . TYR A 1 367 ? 54.855 12.515 36.469 1.00 13.49 ? 367 TYR A CE1 1 ATOM 2833 C CE2 . TYR A 1 367 ? 54.790 10.128 36.734 1.00 14.95 ? 367 TYR A CE2 1 ATOM 2834 C CZ . TYR A 1 367 ? 54.201 11.370 36.900 1.00 14.68 ? 367 TYR A CZ 1 ATOM 2835 O OH . TYR A 1 367 ? 52.965 11.479 37.490 1.00 13.41 ? 367 TYR A OH 1 ATOM 2836 N N . PRO A 1 368 ? 59.280 11.648 31.475 1.00 15.86 ? 368 PRO A N 1 ATOM 2837 C CA . PRO A 1 368 ? 60.503 11.655 30.692 1.00 16.27 ? 368 PRO A CA 1 ATOM 2838 C C . PRO A 1 368 ? 61.432 12.791 31.083 1.00 16.64 ? 368 PRO A C 1 ATOM 2839 O O . PRO A 1 368 ? 60.985 13.882 31.438 1.00 15.98 ? 368 PRO A O 1 ATOM 2840 C CB . PRO A 1 368 ? 60.013 11.897 29.252 1.00 16.78 ? 368 PRO A CB 1 ATOM 2841 C CG . PRO A 1 368 ? 58.731 12.586 29.397 1.00 16.40 ? 368 PRO A CG 1 ATOM 2842 C CD . PRO A 1 368 ? 58.121 12.028 30.647 1.00 15.04 ? 368 PRO A CD 1 ATOM 2843 N N . LEU A 1 369 ? 62.723 12.518 30.976 1.00 16.63 ? 369 LEU A N 1 ATOM 2844 C CA . LEU A 1 369 ? 63.743 13.516 31.244 1.00 16.78 ? 369 LEU A CA 1 ATOM 2845 C C . LEU A 1 369 ? 63.763 14.637 30.200 1.00 16.60 ? 369 LEU A C 1 ATOM 2846 O O . LEU A 1 369 ? 63.431 14.444 29.021 1.00 16.59 ? 369 LEU A O 1 ATOM 2847 C CB . LEU A 1 369 ? 65.116 12.840 31.308 1.00 16.50 ? 369 LEU A CB 1 ATOM 2848 C CG . LEU A 1 369 ? 65.228 11.699 32.331 1.00 18.01 ? 369 LEU A CG 1 ATOM 2849 C CD1 . LEU A 1 369 ? 66.619 11.044 32.293 1.00 18.74 ? 369 LEU A CD1 1 ATOM 2850 C CD2 . LEU A 1 369 ? 64.895 12.175 33.724 1.00 17.78 ? 369 LEU A CD2 1 ATOM 2851 N N . ARG A 1 370 ? 64.182 15.806 30.655 1.00 16.45 ? 370 ARG A N 1 ATOM 2852 C CA . ARG A 1 370 ? 64.456 16.944 29.797 1.00 16.77 ? 370 ARG A CA 1 ATOM 2853 C C . ARG A 1 370 ? 65.400 16.573 28.651 1.00 16.67 ? 370 ARG A C 1 ATOM 2854 O O . ARG A 1 370 ? 66.458 15.975 28.876 1.00 16.58 ? 370 ARG A O 1 ATOM 2855 C CB . ARG A 1 370 ? 65.084 18.054 30.636 1.00 16.96 ? 370 ARG A CB 1 ATOM 2856 C CG . ARG A 1 370 ? 65.238 19.384 29.916 1.00 17.64 ? 370 ARG A CG 1 ATOM 2857 C CD . ARG A 1 370 ? 63.945 20.124 29.674 1.00 17.36 ? 370 ARG A CD 1 ATOM 2858 N NE . ARG A 1 370 ? 64.200 21.407 29.019 1.00 17.28 ? 370 ARG A NE 1 ATOM 2859 C CZ . ARG A 1 370 ? 64.590 22.501 29.653 1.00 18.05 ? 370 ARG A CZ 1 ATOM 2860 N NH1 . ARG A 1 370 ? 64.765 22.484 30.967 1.00 19.13 ? 370 ARG A NH1 1 ATOM 2861 N NH2 . ARG A 1 370 ? 64.794 23.624 28.983 1.00 18.05 ? 370 ARG A NH2 1 ATOM 2862 N N . GLY A 1 371 ? 65.008 16.920 27.427 1.00 16.49 ? 371 GLY A N 1 ATOM 2863 C CA . GLY A 1 371 ? 65.802 16.618 26.242 1.00 16.27 ? 371 GLY A CA 1 ATOM 2864 C C . GLY A 1 371 ? 65.493 15.284 25.589 1.00 16.63 ? 371 GLY A C 1 ATOM 2865 O O . GLY A 1 371 ? 65.966 15.028 24.491 1.00 16.29 ? 371 GLY A O 1 ATOM 2866 N N . SER A 1 372 ? 64.705 14.437 26.252 1.00 16.61 ? 372 SER A N 1 ATOM 2867 C CA . SER A 1 372 ? 64.297 13.147 25.687 1.00 17.03 ? 372 SER A CA 1 ATOM 2868 C C . SER A 1 372 ? 63.329 13.294 24.500 1.00 16.95 ? 372 SER A C 1 ATOM 2869 O O . SER A 1 372 ? 62.501 14.221 24.456 1.00 16.26 ? 372 SER A O 1 ATOM 2870 C CB . SER A 1 372 ? 63.638 12.283 26.767 1.00 17.37 ? 372 SER A CB 1 ATOM 2871 O OG . SER A 1 372 ? 64.599 11.899 27.742 1.00 20.23 ? 372 SER A OG 1 ATOM 2872 N N . SER A 1 373 ? 63.420 12.356 23.558 1.00 16.42 ? 373 SER A N 1 ATOM 2873 C CA . SER A 1 373 ? 62.555 12.367 22.385 1.00 16.23 ? 373 SER A CA 1 ATOM 2874 C C . SER A 1 373 ? 61.109 12.233 22.805 1.00 15.98 ? 373 SER A C 1 ATOM 2875 O O . SER A 1 373 ? 60.791 11.439 23.687 1.00 16.31 ? 373 SER A O 1 ATOM 2876 C CB . SER A 1 373 ? 62.894 11.230 21.424 1.00 16.17 ? 373 SER A CB 1 ATOM 2877 O OG . SER A 1 373 ? 61.942 11.160 20.368 1.00 14.69 ? 373 SER A OG 1 ATOM 2878 N N . ILE A 1 374 ? 60.245 13.003 22.145 1.00 16.31 ? 374 ILE A N 1 ATOM 2879 C CA . ILE A 1 374 ? 58.799 12.942 22.362 1.00 15.89 ? 374 ILE A CA 1 ATOM 2880 C C . ILE A 1 374 ? 58.250 11.578 21.960 1.00 15.95 ? 374 ILE A C 1 ATOM 2881 O O . ILE A 1 374 ? 57.200 11.167 22.443 1.00 16.18 ? 374 ILE A O 1 ATOM 2882 C CB . ILE A 1 374 ? 58.087 14.111 21.614 1.00 16.17 ? 374 ILE A CB 1 ATOM 2883 C CG1 . ILE A 1 374 ? 56.679 14.380 22.165 1.00 16.45 ? 374 ILE A CG1 1 ATOM 2884 C CG2 . ILE A 1 374 ? 58.042 13.878 20.112 1.00 16.12 ? 374 ILE A CG2 1 ATOM 2885 C CD1 . ILE A 1 374 ? 56.639 15.067 23.507 1.00 17.65 ? 374 ILE A CD1 1 ATOM 2886 N N . PHE A 1 375 ? 58.979 10.868 21.098 1.00 16.06 ? 375 PHE A N 1 ATOM 2887 C CA . PHE A 1 375 ? 58.550 9.560 20.613 1.00 16.41 ? 375 PHE A CA 1 ATOM 2888 C C . PHE A 1 375 ? 59.158 8.427 21.426 1.00 16.93 ? 375 PHE A C 1 ATOM 2889 O O . PHE A 1 375 ? 58.941 7.252 21.113 1.00 17.01 ? 375 PHE A O 1 ATOM 2890 C CB . PHE A 1 375 ? 58.890 9.415 19.129 1.00 16.31 ? 375 PHE A CB 1 ATOM 2891 C CG . PHE A 1 375 ? 58.273 10.467 18.284 1.00 15.73 ? 375 PHE A CG 1 ATOM 2892 C CD1 . PHE A 1 375 ? 56.884 10.573 18.208 1.00 15.58 ? 375 PHE A CD1 1 ATOM 2893 C CD2 . PHE A 1 375 ? 59.061 11.362 17.574 1.00 13.62 ? 375 PHE A CD2 1 ATOM 2894 C CE1 . PHE A 1 375 ? 56.295 11.562 17.453 1.00 16.19 ? 375 PHE A CE1 1 ATOM 2895 C CE2 . PHE A 1 375 ? 58.490 12.332 16.797 1.00 16.63 ? 375 PHE A CE2 1 ATOM 2896 C CZ . PHE A 1 375 ? 57.097 12.454 16.734 1.00 17.23 ? 375 PHE A CZ 1 ATOM 2897 N N . GLY A 1 376 ? 59.854 8.785 22.505 1.00 16.67 ? 376 GLY A N 1 ATOM 2898 C CA . GLY A 1 376 ? 60.512 7.829 23.361 1.00 17.39 ? 376 GLY A CA 1 ATOM 2899 C C . GLY A 1 376 ? 59.628 7.130 24.379 1.00 18.05 ? 376 GLY A C 1 ATOM 2900 O O . GLY A 1 376 ? 58.417 7.394 24.517 1.00 17.23 ? 376 GLY A O 1 ATOM 2901 N N . LEU A 1 377 ? 60.273 6.235 25.112 1.00 18.55 ? 377 LEU A N 1 ATOM 2902 C CA . LEU A 1 377 ? 59.632 5.461 26.147 1.00 18.98 ? 377 LEU A CA 1 ATOM 2903 C C . LEU A 1 377 ? 59.647 6.234 27.457 1.00 19.44 ? 377 LEU A C 1 ATOM 2904 O O . LEU A 1 377 ? 60.618 6.929 27.770 1.00 19.14 ? 377 LEU A O 1 ATOM 2905 C CB . LEU A 1 377 ? 60.391 4.149 26.351 1.00 19.00 ? 377 LEU A CB 1 ATOM 2906 C CG . LEU A 1 377 ? 60.599 3.293 25.112 1.00 19.64 ? 377 LEU A CG 1 ATOM 2907 C CD1 . LEU A 1 377 ? 61.461 2.108 25.493 1.00 18.84 ? 377 LEU A CD1 1 ATOM 2908 C CD2 . LEU A 1 377 ? 59.264 2.845 24.532 1.00 20.20 ? 377 LEU A CD2 1 ATOM 2909 N N . ALA A 1 378 ? 58.568 6.105 28.222 1.00 19.96 ? 378 ALA A N 1 ATOM 2910 C CA . ALA A 1 378 ? 58.544 6.618 29.578 1.00 20.44 ? 378 ALA A CA 1 ATOM 2911 C C . ALA A 1 378 ? 59.640 5.893 30.377 1.00 21.11 ? 378 ALA A C 1 ATOM 2912 O O . ALA A 1 378 ? 59.855 4.702 30.175 1.00 20.50 ? 378 ALA A O 1 ATOM 2913 C CB . ALA A 1 378 ? 57.184 6.390 30.215 1.00 20.41 ? 378 ALA A CB 1 ATOM 2914 N N . PRO A 1 379 ? 60.357 6.603 31.247 1.00 21.80 ? 379 PRO A N 1 ATOM 2915 C CA . PRO A 1 379 ? 61.286 5.934 32.162 1.00 22.68 ? 379 PRO A CA 1 ATOM 2916 C C . PRO A 1 379 ? 60.524 4.951 33.035 1.00 23.77 ? 379 PRO A C 1 ATOM 2917 O O . PRO A 1 379 ? 59.419 5.258 33.488 1.00 24.67 ? 379 PRO A O 1 ATOM 2918 C CB . PRO A 1 379 ? 61.832 7.079 33.008 1.00 22.66 ? 379 PRO A CB 1 ATOM 2919 C CG . PRO A 1 379 ? 61.674 8.290 32.139 1.00 22.41 ? 379 PRO A CG 1 ATOM 2920 C CD . PRO A 1 379 ? 60.373 8.064 31.422 1.00 21.90 ? 379 PRO A CD 1 ATOM 2921 N N . GLY A 1 380 ? 61.076 3.768 33.250 1.00 25.13 ? 380 GLY A N 1 ATOM 2922 C CA . GLY A 1 380 ? 60.436 2.816 34.151 1.00 25.60 ? 380 GLY A CA 1 ATOM 2923 C C . GLY A 1 380 ? 59.292 2.033 33.533 1.00 26.05 ? 380 GLY A C 1 ATOM 2924 O O . GLY A 1 380 ? 58.500 2.555 32.729 1.00 26.95 ? 380 GLY A O 1 ATOM 2925 N N . LYS A 1 381 ? 59.187 0.772 33.938 1.00 26.13 ? 381 LYS A N 1 ATOM 2926 C CA . LYS A 1 381 ? 58.268 -0.156 33.313 1.00 25.79 ? 381 LYS A CA 1 ATOM 2927 C C . LYS A 1 381 ? 56.870 0.088 33.828 1.00 25.46 ? 381 LYS A C 1 ATOM 2928 O O . LYS A 1 381 ? 56.695 0.647 34.910 1.00 24.84 ? 381 LYS A O 1 ATOM 2929 C CB . LYS A 1 381 ? 58.696 -1.596 33.611 1.00 26.40 ? 381 LYS A CB 1 ATOM 2930 C CG . LYS A 1 381 ? 60.124 -1.944 33.164 1.00 26.06 ? 381 LYS A CG 1 ATOM 2931 C CD . LYS A 1 381 ? 60.320 -1.778 31.667 1.00 27.37 ? 381 LYS A CD 1 ATOM 2932 C CE . LYS A 1 381 ? 61.736 -2.151 31.245 1.00 28.02 ? 381 LYS A CE 1 ATOM 2933 N NZ . LYS A 1 381 ? 61.931 -2.026 29.770 1.00 28.68 ? 381 LYS A NZ 1 ATOM 2934 N N . ALA A 1 382 ? 55.879 -0.333 33.047 1.00 25.09 ? 382 ALA A N 1 ATOM 2935 C CA . ALA A 1 382 ? 54.490 -0.281 33.476 1.00 24.92 ? 382 ALA A CA 1 ATOM 2936 C C . ALA A 1 382 ? 54.258 -1.406 34.474 1.00 24.97 ? 382 ALA A C 1 ATOM 2937 O O . ALA A 1 382 ? 55.175 -2.167 34.766 1.00 24.94 ? 382 ALA A O 1 ATOM 2938 C CB . ALA A 1 382 ? 53.545 -0.414 32.275 1.00 24.67 ? 382 ALA A CB 1 ATOM 2939 N N . ARG A 1 383 ? 53.035 -1.516 34.981 1.00 25.40 ? 383 ARG A N 1 ATOM 2940 C CA . ARG A 1 383 ? 52.713 -2.502 36.009 1.00 25.97 ? 383 ARG A CA 1 ATOM 2941 C C . ARG A 1 383 ? 52.828 -3.926 35.483 1.00 26.26 ? 383 ARG A C 1 ATOM 2942 O O . ARG A 1 383 ? 52.943 -4.869 36.265 1.00 26.87 ? 383 ARG A O 1 ATOM 2943 C CB . ARG A 1 383 ? 51.303 -2.257 36.553 1.00 26.14 ? 383 ARG A CB 1 ATOM 2944 C CG . ARG A 1 383 ? 50.963 -2.998 37.837 1.00 27.01 ? 383 ARG A CG 1 ATOM 2945 C CD . ARG A 1 383 ? 51.834 -2.619 39.016 1.00 29.06 ? 383 ARG A CD 1 ATOM 2946 N NE . ARG A 1 383 ? 51.291 -3.101 40.283 1.00 29.94 ? 383 ARG A NE 1 ATOM 2947 C CZ . ARG A 1 383 ? 51.430 -4.334 40.758 1.00 30.69 ? 383 ARG A CZ 1 ATOM 2948 N NH1 . ARG A 1 383 ? 50.874 -4.646 41.920 1.00 30.52 ? 383 ARG A NH1 1 ATOM 2949 N NH2 . ARG A 1 383 ? 52.114 -5.256 40.096 1.00 31.82 ? 383 ARG A NH2 1 ATOM 2950 N N . ASP A 1 384 ? 52.797 -4.084 34.162 1.00 26.03 ? 384 ASP A N 1 ATOM 2951 C CA . ASP A 1 384 ? 52.973 -5.399 33.532 1.00 26.37 ? 384 ASP A CA 1 ATOM 2952 C C . ASP A 1 384 ? 54.441 -5.684 33.172 1.00 26.50 ? 384 ASP A C 1 ATOM 2953 O O . ASP A 1 384 ? 54.729 -6.597 32.394 1.00 26.94 ? 384 ASP A O 1 ATOM 2954 C CB . ASP A 1 384 ? 52.077 -5.514 32.294 1.00 26.32 ? 384 ASP A CB 1 ATOM 2955 C CG . ASP A 1 384 ? 52.292 -4.377 31.297 1.00 26.63 ? 384 ASP A CG 1 ATOM 2956 O OD1 . ASP A 1 384 ? 53.302 -3.652 31.431 1.00 25.36 ? 384 ASP A OD1 1 ATOM 2957 O OD2 . ASP A 1 384 ? 51.500 -4.138 30.360 1.00 26.09 ? 384 ASP A OD2 1 ATOM 2958 N N . ARG A 1 385 ? 55.339 -4.885 33.746 1.00 26.92 ? 385 ARG A N 1 ATOM 2959 C CA . ARG A 1 385 ? 56.793 -4.974 33.566 1.00 27.60 ? 385 ARG A CA 1 ATOM 2960 C C . ARG A 1 385 ? 57.250 -4.828 32.121 1.00 26.83 ? 385 ARG A C 1 ATOM 2961 O O . ARG A 1 385 ? 58.300 -5.336 31.747 1.00 27.10 ? 385 ARG A O 1 ATOM 2962 C CB . ARG A 1 385 ? 57.338 -6.273 34.148 1.00 27.64 ? 385 ARG A CB 1 ATOM 2963 C CG . ARG A 1 385 ? 56.966 -6.535 35.593 1.00 28.36 ? 385 ARG A CG 1 ATOM 2964 C CD . ARG A 1 385 ? 57.715 -7.735 36.154 1.00 30.46 ? 385 ARG A CD 1 ATOM 2965 N NE . ARG A 1 385 ? 59.052 -7.401 36.645 1.00 33.24 ? 385 ARG A NE 1 ATOM 2966 C CZ . ARG A 1 385 ? 60.080 -8.243 36.689 1.00 35.24 ? 385 ARG A CZ 1 ATOM 2967 N NH1 . ARG A 1 385 ? 59.966 -9.495 36.246 1.00 36.03 ? 385 ARG A NH1 1 ATOM 2968 N NH2 . ARG A 1 385 ? 61.249 -7.827 37.169 1.00 36.60 ? 385 ARG A NH2 1 ATOM 2969 N N . LYS A 1 386 ? 56.466 -4.130 31.312 1.00 25.70 ? 386 LYS A N 1 ATOM 2970 C CA . LYS A 1 386 ? 56.869 -3.838 29.943 1.00 25.17 ? 386 LYS A CA 1 ATOM 2971 C C . LYS A 1 386 ? 56.927 -2.336 29.761 1.00 23.62 ? 386 LYS A C 1 ATOM 2972 O O . LYS A 1 386 ? 56.344 -1.583 30.551 1.00 22.76 ? 386 LYS A O 1 ATOM 2973 C CB . LYS A 1 386 ? 55.915 -4.503 28.954 1.00 25.62 ? 386 LYS A CB 1 ATOM 2974 C CG . LYS A 1 386 ? 56.014 -6.031 29.042 1.00 27.59 ? 386 LYS A CG 1 ATOM 2975 C CD . LYS A 1 386 ? 55.520 -6.744 27.806 1.00 30.68 ? 386 LYS A CD 1 ATOM 2976 C CE . LYS A 1 386 ? 54.236 -7.484 28.055 1.00 32.15 ? 386 LYS A CE 1 ATOM 2977 N NZ . LYS A 1 386 ? 53.700 -8.048 26.773 1.00 33.94 ? 386 LYS A NZ 1 ATOM 2978 N N . ALA A 1 387 ? 57.661 -1.895 28.746 1.00 22.09 ? 387 ALA A N 1 ATOM 2979 C CA . ALA A 1 387 ? 57.858 -0.471 28.556 1.00 20.89 ? 387 ALA A CA 1 ATOM 2980 C C . ALA A 1 387 ? 56.561 0.153 28.041 1.00 19.82 ? 387 ALA A C 1 ATOM 2981 O O . ALA A 1 387 ? 55.647 -0.547 27.609 1.00 19.60 ? 387 ALA A O 1 ATOM 2982 C CB . ALA A 1 387 ? 58.977 -0.209 27.598 1.00 20.88 ? 387 ALA A CB 1 ATOM 2983 N N . TYR A 1 388 ? 56.472 1.470 28.125 1.00 18.29 ? 388 TYR A N 1 ATOM 2984 C CA . TYR A 1 388 ? 55.380 2.188 27.486 1.00 17.31 ? 388 TYR A CA 1 ATOM 2985 C C . TYR A 1 388 ? 55.873 3.538 27.003 1.00 16.71 ? 388 TYR A C 1 ATOM 2986 O O . TYR A 1 388 ? 56.941 3.982 27.400 1.00 17.14 ? 388 TYR A O 1 ATOM 2987 C CB . TYR A 1 388 ? 54.175 2.324 28.419 1.00 16.78 ? 388 TYR A CB 1 ATOM 2988 C CG . TYR A 1 388 ? 54.359 3.218 29.623 1.00 16.49 ? 388 TYR A CG 1 ATOM 2989 C CD1 . TYR A 1 388 ? 55.059 2.786 30.741 1.00 16.59 ? 388 TYR A CD1 1 ATOM 2990 C CD2 . TYR A 1 388 ? 53.793 4.479 29.655 1.00 16.80 ? 388 TYR A CD2 1 ATOM 2991 C CE1 . TYR A 1 388 ? 55.208 3.595 31.858 1.00 16.10 ? 388 TYR A CE1 1 ATOM 2992 C CE2 . TYR A 1 388 ? 53.929 5.291 30.747 1.00 15.69 ? 388 TYR A CE2 1 ATOM 2993 C CZ . TYR A 1 388 ? 54.630 4.855 31.845 1.00 16.79 ? 388 TYR A CZ 1 ATOM 2994 O OH . TYR A 1 388 ? 54.756 5.684 32.921 1.00 17.50 ? 388 TYR A OH 1 ATOM 2995 N N . THR A 1 389 ? 55.090 4.178 26.135 1.00 16.12 ? 389 THR A N 1 ATOM 2996 C CA . THR A 1 389 ? 55.510 5.419 25.503 1.00 15.81 ? 389 THR A CA 1 ATOM 2997 C C . THR A 1 389 ? 54.977 6.617 26.263 1.00 15.30 ? 389 THR A C 1 ATOM 2998 O O . THR A 1 389 ? 53.946 6.539 26.954 1.00 15.16 ? 389 THR A O 1 ATOM 2999 C CB . THR A 1 389 ? 55.045 5.474 24.038 1.00 15.71 ? 389 THR A CB 1 ATOM 3000 O OG1 . THR A 1 389 ? 53.644 5.197 23.957 1.00 16.69 ? 389 THR A OG1 1 ATOM 3001 C CG2 . THR A 1 389 ? 55.709 4.369 23.211 1.00 15.69 ? 389 THR A CG2 1 ATOM 3002 N N . VAL A 1 390 ? 55.682 7.736 26.127 1.00 14.42 ? 390 VAL A N 1 ATOM 3003 C CA . VAL A 1 390 ? 55.248 8.967 26.758 1.00 14.56 ? 390 VAL A CA 1 ATOM 3004 C C . VAL A 1 390 ? 53.999 9.480 26.029 1.00 14.00 ? 390 VAL A C 1 ATOM 3005 O O . VAL A 1 390 ? 53.124 10.087 26.636 1.00 14.65 ? 390 VAL A O 1 ATOM 3006 C CB . VAL A 1 390 ? 56.376 10.035 26.822 1.00 14.69 ? 390 VAL A CB 1 ATOM 3007 C CG1 . VAL A 1 390 ? 57.589 9.494 27.599 1.00 15.29 ? 390 VAL A CG1 1 ATOM 3008 C CG2 . VAL A 1 390 ? 56.792 10.494 25.484 1.00 15.15 ? 390 VAL A CG2 1 ATOM 3009 N N . LEU A 1 391 ? 53.920 9.204 24.731 1.00 13.47 ? 391 LEU A N 1 ATOM 3010 C CA . LEU A 1 391 ? 52.752 9.550 23.929 1.00 13.43 ? 391 LEU A CA 1 ATOM 3011 C C . LEU A 1 391 ? 51.778 8.392 23.891 1.00 13.61 ? 391 LEU A C 1 ATOM 3012 O O . LEU A 1 391 ? 52.156 7.251 23.587 1.00 12.87 ? 391 LEU A O 1 ATOM 3013 C CB . LEU A 1 391 ? 53.174 9.930 22.520 1.00 12.89 ? 391 LEU A CB 1 ATOM 3014 C CG . LEU A 1 391 ? 54.032 11.195 22.432 1.00 12.52 ? 391 LEU A CG 1 ATOM 3015 C CD1 . LEU A 1 391 ? 54.267 11.546 20.980 1.00 13.17 ? 391 LEU A CD1 1 ATOM 3016 C CD2 . LEU A 1 391 ? 53.365 12.350 23.146 1.00 10.67 ? 391 LEU A CD2 1 ATOM 3017 N N . LEU A 1 392 ? 50.518 8.690 24.203 1.00 14.71 ? 392 LEU A N 1 ATOM 3018 C CA . LEU A 1 392 ? 49.448 7.695 24.186 1.00 14.75 ? 392 LEU A CA 1 ATOM 3019 C C . LEU A 1 392 ? 48.140 8.259 23.666 1.00 14.19 ? 392 LEU A C 1 ATOM 3020 O O . LEU A 1 392 ? 47.969 9.469 23.595 1.00 14.18 ? 392 LEU A O 1 ATOM 3021 C CB . LEU A 1 392 ? 49.227 7.133 25.598 1.00 15.86 ? 392 LEU A CB 1 ATOM 3022 C CG . LEU A 1 392 ? 49.813 5.765 26.010 1.00 17.47 ? 392 LEU A CG 1 ATOM 3023 C CD1 . LEU A 1 392 ? 50.904 5.218 25.181 1.00 18.31 ? 392 LEU A CD1 1 ATOM 3024 C CD2 . LEU A 1 392 ? 50.256 5.797 27.465 1.00 18.45 ? 392 LEU A CD2 1 ATOM 3025 N N . TYR A 1 393 ? 47.230 7.365 23.290 1.00 13.83 ? 393 TYR A N 1 ATOM 3026 C CA . TYR A 1 393 ? 45.871 7.739 22.849 1.00 13.93 ? 393 TYR A CA 1 ATOM 3027 C C . TYR A 1 393 ? 44.828 7.092 23.757 1.00 14.42 ? 393 TYR A C 1 ATOM 3028 O O . TYR A 1 393 ? 45.063 6.027 24.312 1.00 14.76 ? 393 TYR A O 1 ATOM 3029 C CB . TYR A 1 393 ? 45.662 7.353 21.375 1.00 13.45 ? 393 TYR A CB 1 ATOM 3030 C CG . TYR A 1 393 ? 46.441 8.225 20.404 1.00 13.29 ? 393 TYR A CG 1 ATOM 3031 C CD1 . TYR A 1 393 ? 45.939 9.451 19.988 1.00 12.58 ? 393 TYR A CD1 1 ATOM 3032 C CD2 . TYR A 1 393 ? 47.693 7.831 19.913 1.00 12.42 ? 393 TYR A CD2 1 ATOM 3033 C CE1 . TYR A 1 393 ? 46.636 10.255 19.109 1.00 12.27 ? 393 TYR A CE1 1 ATOM 3034 C CE2 . TYR A 1 393 ? 48.416 8.642 19.030 1.00 12.64 ? 393 TYR A CE2 1 ATOM 3035 C CZ . TYR A 1 393 ? 47.876 9.854 18.628 1.00 13.99 ? 393 TYR A CZ 1 ATOM 3036 O OH . TYR A 1 393 ? 48.557 10.664 17.745 1.00 13.58 ? 393 TYR A OH 1 ATOM 3037 N N . GLY A 1 394 ? 43.701 7.764 23.973 1.00 14.45 ? 394 GLY A N 1 ATOM 3038 C CA . GLY A 1 394 ? 42.598 7.162 24.736 1.00 14.59 ? 394 GLY A CA 1 ATOM 3039 C C . GLY A 1 394 ? 42.014 5.982 23.981 1.00 14.51 ? 394 GLY A C 1 ATOM 3040 O O . GLY A 1 394 ? 41.751 4.933 24.547 1.00 14.74 ? 394 GLY A O 1 ATOM 3041 N N . ASN A 1 395 ? 41.844 6.156 22.684 1.00 15.07 ? 395 ASN A N 1 ATOM 3042 C CA . ASN A 1 395 ? 41.296 5.123 21.820 1.00 14.94 ? 395 ASN A CA 1 ATOM 3043 C C . ASN A 1 395 ? 41.997 5.187 20.485 1.00 15.32 ? 395 ASN A C 1 ATOM 3044 O O . ASN A 1 395 ? 42.720 6.151 20.189 1.00 14.43 ? 395 ASN A O 1 ATOM 3045 C CB . ASN A 1 395 ? 39.766 5.286 21.652 1.00 15.30 ? 395 ASN A CB 1 ATOM 3046 C CG . ASN A 1 395 ? 39.374 6.654 21.118 1.00 14.97 ? 395 ASN A CG 1 ATOM 3047 O OD1 . ASN A 1 395 ? 39.893 7.097 20.103 1.00 13.60 ? 395 ASN A OD1 1 ATOM 3048 N ND2 . ASN A 1 395 ? 38.458 7.332 21.814 1.00 13.80 ? 395 ASN A ND2 1 ATOM 3049 N N . GLY A 1 396 ? 41.789 4.154 19.681 1.00 15.25 ? 396 GLY A N 1 ATOM 3050 C CA . GLY A 1 396 ? 42.287 4.156 18.333 1.00 15.53 ? 396 GLY A CA 1 ATOM 3051 C C . GLY A 1 396 ? 43.037 2.899 17.977 1.00 15.28 ? 396 GLY A C 1 ATOM 3052 O O . GLY A 1 396 ? 43.077 1.949 18.758 1.00 15.81 ? 396 GLY A O 1 ATOM 3053 N N . PRO A 1 397 ? 43.628 2.892 16.790 1.00 15.69 ? 397 PRO A N 1 ATOM 3054 C CA . PRO A 1 397 ? 44.123 1.659 16.188 1.00 16.17 ? 397 PRO A CA 1 ATOM 3055 C C . PRO A 1 397 ? 45.493 1.179 16.657 1.00 16.65 ? 397 PRO A C 1 ATOM 3056 O O . PRO A 1 397 ? 46.005 0.201 16.103 1.00 16.69 ? 397 PRO A O 1 ATOM 3057 C CB . PRO A 1 397 ? 44.116 1.982 14.692 1.00 15.87 ? 397 PRO A CB 1 ATOM 3058 C CG . PRO A 1 397 ? 44.350 3.473 14.626 1.00 15.84 ? 397 PRO A CG 1 ATOM 3059 C CD . PRO A 1 397 ? 43.812 4.048 15.900 1.00 15.42 ? 397 PRO A CD 1 ATOM 3060 N N . GLY A 1 398 ? 46.063 1.831 17.668 1.00 17.00 ? 398 GLY A N 1 ATOM 3061 C CA . GLY A 1 398 ? 47.309 1.384 18.288 1.00 17.23 ? 398 GLY A CA 1 ATOM 3062 C C . GLY A 1 398 ? 47.087 0.446 19.464 1.00 18.05 ? 398 GLY A C 1 ATOM 3063 O O . GLY A 1 398 ? 48.055 -0.088 20.033 1.00 17.04 ? 398 GLY A O 1 ATOM 3064 N N . TYR A 1 399 ? 45.823 0.235 19.834 1.00 19.04 ? 399 TYR A N 1 ATOM 3065 C CA . TYR A 1 399 ? 45.481 -0.811 20.796 1.00 20.21 ? 399 TYR A CA 1 ATOM 3066 C C . TYR A 1 399 ? 45.886 -2.139 20.190 1.00 21.54 ? 399 TYR A C 1 ATOM 3067 O O . TYR A 1 399 ? 45.384 -2.532 19.127 1.00 21.06 ? 399 TYR A O 1 ATOM 3068 C CB . TYR A 1 399 ? 43.984 -0.840 21.120 1.00 19.93 ? 399 TYR A CB 1 ATOM 3069 C CG . TYR A 1 399 ? 43.628 -1.862 22.180 1.00 19.40 ? 399 TYR A CG 1 ATOM 3070 C CD1 . TYR A 1 399 ? 43.411 -3.192 21.856 1.00 18.45 ? 399 TYR A CD1 1 ATOM 3071 C CD2 . TYR A 1 399 ? 43.511 -1.490 23.508 1.00 20.17 ? 399 TYR A CD2 1 ATOM 3072 C CE1 . TYR A 1 399 ? 43.079 -4.120 22.839 1.00 20.28 ? 399 TYR A CE1 1 ATOM 3073 C CE2 . TYR A 1 399 ? 43.200 -2.392 24.480 1.00 19.27 ? 399 TYR A CE2 1 ATOM 3074 C CZ . TYR A 1 399 ? 42.986 -3.708 24.149 1.00 19.06 ? 399 TYR A CZ 1 ATOM 3075 O OH . TYR A 1 399 ? 42.680 -4.577 25.151 1.00 18.97 ? 399 TYR A OH 1 ATOM 3076 N N . VAL A 1 400 ? 46.788 -2.830 20.874 1.00 23.61 ? 400 VAL A N 1 ATOM 3077 C CA . VAL A 1 400 ? 47.251 -4.125 20.418 1.00 25.70 ? 400 VAL A CA 1 ATOM 3078 C C . VAL A 1 400 ? 47.299 -5.094 21.576 1.00 27.41 ? 400 VAL A C 1 ATOM 3079 O O . VAL A 1 400 ? 47.653 -4.724 22.696 1.00 27.51 ? 400 VAL A O 1 ATOM 3080 C CB . VAL A 1 400 ? 48.659 -4.052 19.763 1.00 26.13 ? 400 VAL A CB 1 ATOM 3081 C CG1 . VAL A 1 400 ? 49.107 -5.442 19.297 1.00 26.78 ? 400 VAL A CG1 1 ATOM 3082 C CG2 . VAL A 1 400 ? 48.654 -3.117 18.593 1.00 25.77 ? 400 VAL A CG2 1 ATOM 3083 N N . LEU A 1 401 ? 46.894 -6.329 21.295 1.00 29.78 ? 401 LEU A N 1 ATOM 3084 C CA . LEU A 1 401 ? 47.211 -7.466 22.147 1.00 31.58 ? 401 LEU A CA 1 ATOM 3085 C C . LEU A 1 401 ? 47.959 -8.485 21.311 1.00 33.60 ? 401 LEU A C 1 ATOM 3086 O O . LEU A 1 401 ? 47.392 -9.063 20.378 1.00 34.13 ? 401 LEU A O 1 ATOM 3087 C CB . LEU A 1 401 ? 45.945 -8.065 22.722 1.00 31.71 ? 401 LEU A CB 1 ATOM 3088 C CG . LEU A 1 401 ? 45.244 -7.095 23.672 1.00 31.28 ? 401 LEU A CG 1 ATOM 3089 C CD1 . LEU A 1 401 ? 43.811 -7.495 23.856 1.00 31.94 ? 401 LEU A CD1 1 ATOM 3090 C CD2 . LEU A 1 401 ? 45.967 -7.014 25.016 1.00 31.09 ? 401 LEU A CD2 1 ATOM 3091 N N . LYS A 1 402 ? 49.249 -8.652 21.622 1.00 35.56 ? 402 LYS A N 1 ATOM 3092 C CA . LYS A 1 402 ? 50.093 -9.680 21.023 1.00 37.10 ? 402 LYS A CA 1 ATOM 3093 C C . LYS A 1 402 ? 50.137 -10.859 21.997 1.00 37.72 ? 402 LYS A C 1 ATOM 3094 O O . LYS A 1 402 ? 50.464 -10.696 23.174 1.00 37.86 ? 402 LYS A O 1 ATOM 3095 C CB . LYS A 1 402 ? 51.493 -9.133 20.703 1.00 37.18 ? 402 LYS A CB 1 ATOM 3096 C CG . LYS A 1 402 ? 51.488 -8.091 19.554 1.00 38.13 ? 402 LYS A CG 1 ATOM 3097 C CD . LYS A 1 402 ? 52.774 -8.091 18.673 1.00 38.26 ? 402 LYS A CD 1 ATOM 3098 C CE . LYS A 1 402 ? 53.870 -7.118 19.147 1.00 39.34 ? 402 LYS A CE 1 ATOM 3099 N NZ . LYS A 1 402 ? 54.926 -7.742 20.015 1.00 39.01 ? 402 LYS A NZ 1 ATOM 3100 N N . ASP A 1 403 ? 49.780 -12.037 21.486 1.00 38.65 ? 403 ASP A N 1 ATOM 3101 C CA . ASP A 1 403 ? 49.327 -13.174 22.294 1.00 39.27 ? 403 ASP A CA 1 ATOM 3102 C C . ASP A 1 403 ? 48.806 -12.781 23.681 1.00 38.76 ? 403 ASP A C 1 ATOM 3103 O O . ASP A 1 403 ? 49.450 -13.025 24.709 1.00 39.56 ? 403 ASP A O 1 ATOM 3104 C CB . ASP A 1 403 ? 50.404 -14.267 22.387 1.00 39.97 ? 403 ASP A CB 1 ATOM 3105 C CG . ASP A 1 403 ? 49.872 -15.572 22.989 1.00 42.26 ? 403 ASP A CG 1 ATOM 3106 O OD1 . ASP A 1 403 ? 48.742 -15.991 22.627 1.00 45.63 ? 403 ASP A OD1 1 ATOM 3107 O OD2 . ASP A 1 403 ? 50.516 -16.245 23.829 1.00 45.29 ? 403 ASP A OD2 1 ATOM 3108 N N . GLY A 1 404 ? 47.643 -12.142 23.687 1.00 37.99 ? 404 GLY A N 1 ATOM 3109 C CA . GLY A 1 404 ? 46.857 -11.972 24.913 1.00 37.34 ? 404 GLY A CA 1 ATOM 3110 C C . GLY A 1 404 ? 47.323 -10.934 25.912 1.00 36.52 ? 404 GLY A C 1 ATOM 3111 O O . GLY A 1 404 ? 46.812 -10.885 27.038 1.00 36.85 ? 404 GLY A O 1 ATOM 3112 N N . ALA A 1 405 ? 48.278 -10.094 25.521 1.00 35.20 ? 405 ALA A N 1 ATOM 3113 C CA . ALA A 1 405 ? 48.767 -9.057 26.427 1.00 33.88 ? 405 ALA A CA 1 ATOM 3114 C C . ALA A 1 405 ? 49.319 -7.849 25.696 1.00 32.11 ? 405 ALA A C 1 ATOM 3115 O O . ALA A 1 405 ? 49.651 -7.914 24.509 1.00 31.81 ? 405 ALA A O 1 ATOM 3116 C CB . ALA A 1 405 ? 49.816 -9.624 27.357 1.00 34.00 ? 405 ALA A CB 1 ATOM 3117 N N . ARG A 1 406 ? 49.420 -6.752 26.436 1.00 30.18 ? 406 ARG A N 1 ATOM 3118 C CA . ARG A 1 406 ? 49.926 -5.509 25.899 1.00 28.63 ? 406 ARG A CA 1 ATOM 3119 C C . ARG A 1 406 ? 51.368 -5.761 25.508 1.00 28.36 ? 406 ARG A C 1 ATOM 3120 O O . ARG A 1 406 ? 52.126 -6.268 26.321 1.00 28.17 ? 406 ARG A O 1 ATOM 3121 C CB . ARG A 1 406 ? 49.853 -4.408 26.953 1.00 28.19 ? 406 ARG A CB 1 ATOM 3122 C CG . ARG A 1 406 ? 50.133 -3.020 26.424 1.00 26.44 ? 406 ARG A CG 1 ATOM 3123 C CD . ARG A 1 406 ? 50.092 -1.966 27.501 1.00 25.79 ? 406 ARG A CD 1 ATOM 3124 N NE . ARG A 1 406 ? 51.228 -2.100 28.407 1.00 23.91 ? 406 ARG A NE 1 ATOM 3125 C CZ . ARG A 1 406 ? 52.451 -1.635 28.169 1.00 22.68 ? 406 ARG A CZ 1 ATOM 3126 N NH1 . ARG A 1 406 ? 52.711 -0.974 27.056 1.00 21.07 ? 406 ARG A NH1 1 ATOM 3127 N NH2 . ARG A 1 406 ? 53.418 -1.830 29.060 1.00 22.74 ? 406 ARG A NH2 1 ATOM 3128 N N . PRO A 1 407 ? 51.750 -5.433 24.280 1.00 28.02 ? 407 PRO A N 1 ATOM 3129 C CA . PRO A 1 407 ? 53.096 -5.717 23.827 1.00 27.74 ? 407 PRO A CA 1 ATOM 3130 C C . PRO A 1 407 ? 54.106 -4.724 24.383 1.00 27.29 ? 407 PRO A C 1 ATOM 3131 O O . PRO A 1 407 ? 53.802 -3.544 24.584 1.00 26.72 ? 407 PRO A O 1 ATOM 3132 C CB . PRO A 1 407 ? 52.996 -5.584 22.313 1.00 28.19 ? 407 PRO A CB 1 ATOM 3133 C CG . PRO A 1 407 ? 51.922 -4.590 22.110 1.00 28.59 ? 407 PRO A CG 1 ATOM 3134 C CD . PRO A 1 407 ? 50.946 -4.777 23.232 1.00 28.01 ? 407 PRO A CD 1 ATOM 3135 N N . ASP A 1 408 ? 55.301 -5.234 24.640 1.00 26.80 ? 408 ASP A N 1 ATOM 3136 C CA . ASP A 1 408 ? 56.431 -4.410 24.981 1.00 26.50 ? 408 ASP A CA 1 ATOM 3137 C C . ASP A 1 408 ? 56.719 -3.524 23.773 1.00 25.94 ? 408 ASP A C 1 ATOM 3138 O O . ASP A 1 408 ? 56.233 -3.787 22.662 1.00 25.78 ? 408 ASP A O 1 ATOM 3139 C CB . ASP A 1 408 ? 57.637 -5.295 25.313 1.00 26.53 ? 408 ASP A CB 1 ATOM 3140 C CG . ASP A 1 408 ? 58.541 -4.686 26.365 1.00 27.59 ? 408 ASP A CG 1 ATOM 3141 O OD1 . ASP A 1 408 ? 58.532 -3.456 26.548 1.00 26.48 ? 408 ASP A OD1 1 ATOM 3142 O OD2 . ASP A 1 408 ? 59.292 -5.384 27.073 1.00 31.77 ? 408 ASP A OD2 1 ATOM 3143 N N . VAL A 1 409 ? 57.492 -2.472 23.989 1.00 25.04 ? 409 VAL A N 1 ATOM 3144 C CA . VAL A 1 409 ? 57.880 -1.583 22.909 1.00 24.49 ? 409 VAL A CA 1 ATOM 3145 C C . VAL A 1 409 ? 59.281 -1.043 23.173 1.00 23.81 ? 409 VAL A C 1 ATOM 3146 O O . VAL A 1 409 ? 59.655 -0.799 24.318 1.00 23.35 ? 409 VAL A O 1 ATOM 3147 C CB . VAL A 1 409 ? 56.830 -0.441 22.680 1.00 24.76 ? 409 VAL A CB 1 ATOM 3148 C CG1 . VAL A 1 409 ? 56.322 0.120 23.979 1.00 25.81 ? 409 VAL A CG1 1 ATOM 3149 C CG2 . VAL A 1 409 ? 57.384 0.667 21.773 1.00 24.57 ? 409 VAL A CG2 1 ATOM 3150 N N . THR A 1 410 ? 60.057 -0.891 22.103 1.00 23.09 ? 410 THR A N 1 ATOM 3151 C CA . THR A 1 410 ? 61.424 -0.415 22.198 1.00 22.76 ? 410 THR A CA 1 ATOM 3152 C C . THR A 1 410 ? 61.525 0.998 21.677 1.00 22.55 ? 410 THR A C 1 ATOM 3153 O O . THR A 1 410 ? 60.608 1.480 21.021 1.00 22.09 ? 410 THR A O 1 ATOM 3154 C CB . THR A 1 410 ? 62.350 -1.315 21.369 1.00 22.99 ? 410 THR A CB 1 ATOM 3155 O OG1 . THR A 1 410 ? 61.990 -1.232 19.981 1.00 22.58 ? 410 THR A OG1 1 ATOM 3156 C CG2 . THR A 1 410 ? 62.149 -2.761 21.743 1.00 23.15 ? 410 THR A CG2 1 ATOM 3157 N N . GLU A 1 411 ? 62.658 1.642 21.939 1.00 22.64 ? 411 GLU A N 1 ATOM 3158 C CA . GLU A 1 411 ? 62.906 3.003 21.453 1.00 23.26 ? 411 GLU A CA 1 ATOM 3159 C C . GLU A 1 411 ? 62.921 3.084 19.931 1.00 23.61 ? 411 GLU A C 1 ATOM 3160 O O . GLU A 1 411 ? 62.334 4.003 19.351 1.00 23.93 ? 411 GLU A O 1 ATOM 3161 C CB . GLU A 1 411 ? 64.214 3.565 22.028 1.00 23.05 ? 411 GLU A CB 1 ATOM 3162 C CG . GLU A 1 411 ? 64.110 4.042 23.472 1.00 24.07 ? 411 GLU A CG 1 ATOM 3163 C CD . GLU A 1 411 ? 63.562 5.459 23.624 1.00 24.90 ? 411 GLU A CD 1 ATOM 3164 O OE1 . GLU A 1 411 ? 63.570 6.239 22.640 1.00 27.64 ? 411 GLU A OE1 1 ATOM 3165 O OE2 . GLU A 1 411 ? 63.157 5.814 24.753 1.00 23.55 ? 411 GLU A OE2 1 ATOM 3166 N N . SER A 1 412 ? 63.576 2.129 19.269 1.00 24.12 ? 412 SER A N 1 ATOM 3167 C CA . SER A 1 412 ? 63.645 2.154 17.799 1.00 24.36 ? 412 SER A CA 1 ATOM 3168 C C . SER A 1 412 ? 62.247 2.052 17.211 1.00 23.70 ? 412 SER A C 1 ATOM 3169 O O . SER A 1 412 ? 61.908 2.740 16.255 1.00 23.16 ? 412 SER A O 1 ATOM 3170 C CB . SER A 1 412 ? 64.518 1.014 17.254 1.00 24.96 ? 412 SER A CB 1 ATOM 3171 O OG . SER A 1 412 ? 63.950 -0.243 17.579 1.00 27.29 ? 412 SER A OG 1 ATOM 3172 N N . GLU A 1 413 ? 61.443 1.188 17.809 1.00 23.34 ? 413 GLU A N 1 ATOM 3173 C CA . GLU A 1 413 ? 60.064 0.998 17.406 1.00 23.84 ? 413 GLU A CA 1 ATOM 3174 C C . GLU A 1 413 ? 59.216 2.245 17.678 1.00 22.45 ? 413 GLU A C 1 ATOM 3175 O O . GLU A 1 413 ? 58.554 2.752 16.787 1.00 21.61 ? 413 GLU A O 1 ATOM 3176 C CB . GLU A 1 413 ? 59.503 -0.191 18.165 1.00 23.83 ? 413 GLU A CB 1 ATOM 3177 C CG . GLU A 1 413 ? 58.019 -0.427 17.986 1.00 26.27 ? 413 GLU A CG 1 ATOM 3178 C CD . GLU A 1 413 ? 57.551 -1.619 18.786 1.00 26.83 ? 413 GLU A CD 1 ATOM 3179 O OE1 . GLU A 1 413 ? 58.310 -2.070 19.685 1.00 31.44 ? 413 GLU A OE1 1 ATOM 3180 O OE2 . GLU A 1 413 ? 56.440 -2.111 18.504 1.00 31.95 ? 413 GLU A OE2 1 ATOM 3181 N N . SER A 1 414 ? 59.256 2.726 18.917 1.00 21.52 ? 414 SER A N 1 ATOM 3182 C CA . SER A 1 414 ? 58.478 3.908 19.317 1.00 20.77 ? 414 SER A CA 1 ATOM 3183 C C . SER A 1 414 ? 58.785 5.129 18.443 1.00 20.51 ? 414 SER A C 1 ATOM 3184 O O . SER A 1 414 ? 57.933 5.988 18.254 1.00 20.05 ? 414 SER A O 1 ATOM 3185 C CB . SER A 1 414 ? 58.712 4.223 20.796 1.00 20.48 ? 414 SER A CB 1 ATOM 3186 O OG . SER A 1 414 ? 59.944 4.891 21.032 1.00 19.25 ? 414 SER A OG 1 ATOM 3187 N N . GLY A 1 415 ? 60.003 5.183 17.904 1.00 20.56 ? 415 GLY A N 1 ATOM 3188 C CA . GLY A 1 415 ? 60.469 6.324 17.137 1.00 20.91 ? 415 GLY A CA 1 ATOM 3189 C C . GLY A 1 415 ? 60.224 6.246 15.649 1.00 21.03 ? 415 GLY A C 1 ATOM 3190 O O . GLY A 1 415 ? 60.563 7.171 14.927 1.00 20.90 ? 415 GLY A O 1 ATOM 3191 N N . SER A 1 416 ? 59.657 5.137 15.182 1.00 21.46 ? 416 SER A N 1 ATOM 3192 C CA . SER A 1 416 ? 59.417 4.954 13.755 1.00 21.87 ? 416 SER A CA 1 ATOM 3193 C C . SER A 1 416 ? 58.272 5.835 13.270 1.00 21.60 ? 416 SER A C 1 ATOM 3194 O O . SER A 1 416 ? 57.251 5.919 13.934 1.00 20.88 ? 416 SER A O 1 ATOM 3195 C CB . SER A 1 416 ? 59.066 3.497 13.456 1.00 21.98 ? 416 SER A CB 1 ATOM 3196 O OG . SER A 1 416 ? 58.423 3.394 12.199 1.00 24.15 ? 416 SER A OG 1 ATOM 3197 N N . PRO A 1 417 ? 58.403 6.423 12.076 1.00 21.71 ? 417 PRO A N 1 ATOM 3198 C CA . PRO A 1 417 ? 57.338 7.242 11.517 1.00 21.89 ? 417 PRO A CA 1 ATOM 3199 C C . PRO A 1 417 ? 56.011 6.497 11.310 1.00 21.74 ? 417 PRO A C 1 ATOM 3200 O O . PRO A 1 417 ? 54.973 7.139 11.141 1.00 22.57 ? 417 PRO A O 1 ATOM 3201 C CB . PRO A 1 417 ? 57.906 7.699 10.161 1.00 21.98 ? 417 PRO A CB 1 ATOM 3202 C CG . PRO A 1 417 ? 59.348 7.423 10.203 1.00 22.12 ? 417 PRO A CG 1 ATOM 3203 C CD . PRO A 1 417 ? 59.554 6.308 11.163 1.00 22.21 ? 417 PRO A CD 1 ATOM 3204 N N . GLU A 1 418 ? 56.042 5.168 11.320 1.00 21.29 ? 418 GLU A N 1 ATOM 3205 C CA . GLU A 1 418 ? 54.847 4.362 11.090 1.00 21.29 ? 418 GLU A CA 1 ATOM 3206 C C . GLU A 1 418 ? 54.248 3.843 12.397 1.00 20.15 ? 418 GLU A C 1 ATOM 3207 O O . GLU A 1 418 ? 53.228 3.145 12.390 1.00 19.83 ? 418 GLU A O 1 ATOM 3208 C CB . GLU A 1 418 ? 55.176 3.186 10.173 1.00 22.04 ? 418 GLU A CB 1 ATOM 3209 C CG . GLU A 1 418 ? 55.173 3.539 8.691 1.00 24.81 ? 418 GLU A CG 1 ATOM 3210 C CD . GLU A 1 418 ? 56.248 4.530 8.322 1.00 27.54 ? 418 GLU A CD 1 ATOM 3211 O OE1 . GLU A 1 418 ? 57.449 4.183 8.430 1.00 29.83 ? 418 GLU A OE1 1 ATOM 3212 O OE2 . GLU A 1 418 ? 55.890 5.659 7.919 1.00 30.90 ? 418 GLU A OE2 1 ATOM 3213 N N . TYR A 1 419 ? 54.879 4.187 13.513 1.00 18.79 ? 419 TYR A N 1 ATOM 3214 C CA . TYR A 1 419 ? 54.502 3.640 14.796 1.00 17.80 ? 419 TYR A CA 1 ATOM 3215 C C . TYR A 1 419 ? 53.173 4.215 15.259 1.00 17.38 ? 419 TYR A C 1 ATOM 3216 O O . TYR A 1 419 ? 52.956 5.412 15.168 1.00 17.64 ? 419 TYR A O 1 ATOM 3217 C CB . TYR A 1 419 ? 55.572 3.919 15.851 1.00 17.39 ? 419 TYR A CB 1 ATOM 3218 C CG . TYR A 1 419 ? 55.189 3.342 17.176 1.00 16.27 ? 419 TYR A CG 1 ATOM 3219 C CD1 . TYR A 1 419 ? 55.104 1.972 17.340 1.00 16.70 ? 419 TYR A CD1 1 ATOM 3220 C CD2 . TYR A 1 419 ? 54.838 4.154 18.250 1.00 15.97 ? 419 TYR A CD2 1 ATOM 3221 C CE1 . TYR A 1 419 ? 54.720 1.418 18.533 1.00 17.20 ? 419 TYR A CE1 1 ATOM 3222 C CE2 . TYR A 1 419 ? 54.465 3.595 19.465 1.00 15.52 ? 419 TYR A CE2 1 ATOM 3223 C CZ . TYR A 1 419 ? 54.399 2.226 19.589 1.00 15.69 ? 419 TYR A CZ 1 ATOM 3224 O OH . TYR A 1 419 ? 54.022 1.641 20.769 1.00 16.09 ? 419 TYR A OH 1 ATOM 3225 N N . ARG A 1 420 ? 52.297 3.336 15.739 1.00 16.92 ? 420 ARG A N 1 ATOM 3226 C CA . ARG A 1 420 ? 51.022 3.724 16.300 1.00 16.95 ? 420 ARG A CA 1 ATOM 3227 C C . ARG A 1 420 ? 51.135 3.623 17.813 1.00 16.76 ? 420 ARG A C 1 ATOM 3228 O O . ARG A 1 420 ? 51.406 2.547 18.343 1.00 16.63 ? 420 ARG A O 1 ATOM 3229 C CB . ARG A 1 420 ? 49.911 2.784 15.850 1.00 17.03 ? 420 ARG A CB 1 ATOM 3230 C CG . ARG A 1 420 ? 49.615 2.718 14.354 1.00 17.99 ? 420 ARG A CG 1 ATOM 3231 C CD . ARG A 1 420 ? 48.306 1.964 14.107 1.00 17.88 ? 420 ARG A CD 1 ATOM 3232 N NE . ARG A 1 420 ? 48.086 1.548 12.722 1.00 19.99 ? 420 ARG A NE 1 ATOM 3233 C CZ . ARG A 1 420 ? 47.353 2.196 11.825 1.00 19.96 ? 420 ARG A CZ 1 ATOM 3234 N NH1 . ARG A 1 420 ? 46.759 3.348 12.119 1.00 21.91 ? 420 ARG A NH1 1 ATOM 3235 N NH2 . ARG A 1 420 ? 47.212 1.692 10.610 1.00 20.36 ? 420 ARG A NH2 1 ATOM 3236 N N . GLN A 1 421 ? 50.937 4.727 18.523 1.00 16.62 ? 421 GLN A N 1 ATOM 3237 C CA . GLN A 1 421 ? 50.981 4.667 19.984 1.00 16.00 ? 421 GLN A CA 1 ATOM 3238 C C . GLN A 1 421 ? 49.795 3.872 20.506 1.00 16.01 ? 421 GLN A C 1 ATOM 3239 O O . GLN A 1 421 ? 48.731 3.830 19.891 1.00 17.04 ? 421 GLN A O 1 ATOM 3240 C CB . GLN A 1 421 ? 51.023 6.072 20.610 1.00 16.19 ? 421 GLN A CB 1 ATOM 3241 C CG . GLN A 1 421 ? 52.347 6.787 20.418 1.00 15.08 ? 421 GLN A CG 1 ATOM 3242 C CD . GLN A 1 421 ? 52.542 7.377 19.038 1.00 14.80 ? 421 GLN A CD 1 ATOM 3243 O OE1 . GLN A 1 421 ? 51.586 7.573 18.284 1.00 13.58 ? 421 GLN A OE1 1 ATOM 3244 N NE2 . GLN A 1 421 ? 53.787 7.663 18.702 1.00 14.94 ? 421 GLN A NE2 1 ATOM 3245 N N . GLN A 1 422 ? 49.979 3.226 21.643 1.00 15.81 ? 422 GLN A N 1 ATOM 3246 C CA . GLN A 1 422 ? 48.910 2.428 22.236 1.00 15.87 ? 422 GLN A CA 1 ATOM 3247 C C . GLN A 1 422 ? 47.737 3.268 22.737 1.00 15.95 ? 422 GLN A C 1 ATOM 3248 O O . GLN A 1 422 ? 47.876 4.468 22.995 1.00 15.84 ? 422 GLN A O 1 ATOM 3249 C CB . GLN A 1 422 ? 49.472 1.574 23.349 1.00 15.45 ? 422 GLN A CB 1 ATOM 3250 C CG . GLN A 1 422 ? 50.418 0.526 22.802 1.00 15.51 ? 422 GLN A CG 1 ATOM 3251 C CD . GLN A 1 422 ? 51.139 -0.212 23.871 1.00 16.12 ? 422 GLN A CD 1 ATOM 3252 O OE1 . GLN A 1 422 ? 50.907 0.027 25.062 1.00 17.24 ? 422 GLN A OE1 1 ATOM 3253 N NE2 . GLN A 1 422 ? 52.025 -1.120 23.465 1.00 17.16 ? 422 GLN A NE2 1 ATOM 3254 N N . SER A 1 423 ? 46.580 2.620 22.826 1.00 15.72 ? 423 SER A N 1 ATOM 3255 C CA . SER A 1 423 ? 45.370 3.221 23.354 1.00 15.70 ? 423 SER A CA 1 ATOM 3256 C C . SER A 1 423 ? 44.680 2.244 24.292 1.00 15.99 ? 423 SER A C 1 ATOM 3257 O O . SER A 1 423 ? 45.102 1.086 24.417 1.00 15.83 ? 423 SER A O 1 ATOM 3258 C CB . SER A 1 423 ? 44.417 3.620 22.223 1.00 15.71 ? 423 SER A CB 1 ATOM 3259 O OG . SER A 1 423 ? 43.796 2.483 21.619 1.00 15.55 ? 423 SER A OG 1 ATOM 3260 N N . ALA A 1 424 ? 43.635 2.733 24.953 1.00 15.80 ? 424 ALA A N 1 ATOM 3261 C CA . ALA A 1 424 ? 42.848 1.945 25.906 1.00 15.99 ? 424 ALA A CA 1 ATOM 3262 C C . ALA A 1 424 ? 41.762 1.135 25.203 1.00 16.21 ? 424 ALA A C 1 ATOM 3263 O O . ALA A 1 424 ? 41.265 0.149 25.756 1.00 16.41 ? 424 ALA A O 1 ATOM 3264 C CB . ALA A 1 424 ? 42.205 2.854 26.913 1.00 15.83 ? 424 ALA A CB 1 ATOM 3265 N N . VAL A 1 425 ? 41.374 1.585 24.009 1.00 16.03 ? 425 VAL A N 1 ATOM 3266 C CA . VAL A 1 425 ? 40.199 1.053 23.316 1.00 16.47 ? 425 VAL A CA 1 ATOM 3267 C C . VAL A 1 425 ? 40.469 0.960 21.822 1.00 16.33 ? 425 VAL A C 1 ATOM 3268 O O . VAL A 1 425 ? 40.769 1.972 21.191 1.00 17.23 ? 425 VAL A O 1 ATOM 3269 C CB . VAL A 1 425 ? 38.964 1.960 23.542 1.00 16.09 ? 425 VAL A CB 1 ATOM 3270 C CG1 . VAL A 1 425 ? 37.729 1.416 22.825 1.00 16.11 ? 425 VAL A CG1 1 ATOM 3271 C CG2 . VAL A 1 425 ? 38.696 2.127 25.012 1.00 16.64 ? 425 VAL A CG2 1 ATOM 3272 N N . PRO A 1 426 ? 40.350 -0.236 21.248 1.00 16.57 ? 426 PRO A N 1 ATOM 3273 C CA . PRO A 1 426 ? 40.582 -0.412 19.829 1.00 16.65 ? 426 PRO A CA 1 ATOM 3274 C C . PRO A 1 426 ? 39.508 0.267 18.989 1.00 16.35 ? 426 PRO A C 1 ATOM 3275 O O . PRO A 1 426 ? 38.325 -0.018 19.164 1.00 17.22 ? 426 PRO A O 1 ATOM 3276 C CB . PRO A 1 426 ? 40.522 -1.929 19.651 1.00 16.89 ? 426 PRO A CB 1 ATOM 3277 C CG . PRO A 1 426 ? 39.660 -2.391 20.761 1.00 16.42 ? 426 PRO A CG 1 ATOM 3278 C CD . PRO A 1 426 ? 39.983 -1.507 21.902 1.00 16.33 ? 426 PRO A CD 1 ATOM 3279 N N . LEU A 1 427 ? 39.919 1.176 18.110 1.00 16.39 ? 427 LEU A N 1 ATOM 3280 C CA . LEU A 1 427 ? 39.025 1.721 17.079 1.00 16.23 ? 427 LEU A CA 1 ATOM 3281 C C . LEU A 1 427 ? 39.801 1.833 15.774 1.00 16.86 ? 427 LEU A C 1 ATOM 3282 O O . LEU A 1 427 ? 41.005 2.119 15.795 1.00 16.80 ? 427 LEU A O 1 ATOM 3283 C CB . LEU A 1 427 ? 38.497 3.099 17.478 1.00 16.45 ? 427 LEU A CB 1 ATOM 3284 C CG . LEU A 1 427 ? 37.608 3.312 18.714 1.00 16.73 ? 427 LEU A CG 1 ATOM 3285 C CD1 . LEU A 1 427 ? 37.359 4.802 18.893 1.00 17.99 ? 427 LEU A CD1 1 ATOM 3286 C CD2 . LEU A 1 427 ? 36.277 2.597 18.640 1.00 17.88 ? 427 LEU A CD2 1 ATOM 3287 N N . ASP A 1 428 ? 39.138 1.617 14.637 1.00 17.37 ? 428 ASP A N 1 ATOM 3288 C CA . ASP A 1 428 ? 39.802 1.789 13.340 1.00 18.05 ? 428 ASP A CA 1 ATOM 3289 C C . ASP A 1 428 ? 40.434 3.159 13.233 1.00 17.77 ? 428 ASP A C 1 ATOM 3290 O O . ASP A 1 428 ? 41.532 3.308 12.702 1.00 18.25 ? 428 ASP A O 1 ATOM 3291 C CB . ASP A 1 428 ? 38.828 1.614 12.189 1.00 18.53 ? 428 ASP A CB 1 ATOM 3292 C CG . ASP A 1 428 ? 38.552 0.178 11.893 1.00 20.21 ? 428 ASP A CG 1 ATOM 3293 O OD1 . ASP A 1 428 ? 37.492 -0.099 11.308 1.00 25.52 ? 428 ASP A OD1 1 ATOM 3294 O OD2 . ASP A 1 428 ? 39.321 -0.742 12.224 1.00 24.21 ? 428 ASP A OD2 1 ATOM 3295 N N . GLU A 1 429 ? 39.725 4.155 13.742 1.00 17.85 ? 429 GLU A N 1 ATOM 3296 C CA . GLU A 1 429 ? 40.241 5.512 13.826 1.00 17.76 ? 429 GLU A CA 1 ATOM 3297 C C . GLU A 1 429 ? 40.092 6.031 15.235 1.00 16.79 ? 429 GLU A C 1 ATOM 3298 O O . GLU A 1 429 ? 39.037 5.906 15.865 1.00 16.60 ? 429 GLU A O 1 ATOM 3299 C CB . GLU A 1 429 ? 39.512 6.446 12.871 1.00 18.76 ? 429 GLU A CB 1 ATOM 3300 C CG . GLU A 1 429 ? 39.656 6.037 11.415 1.00 21.95 ? 429 GLU A CG 1 ATOM 3301 C CD . GLU A 1 429 ? 39.722 7.205 10.454 1.00 27.16 ? 429 GLU A CD 1 ATOM 3302 O OE1 . GLU A 1 429 ? 38.868 8.111 10.535 1.00 30.30 ? 429 GLU A OE1 1 ATOM 3303 O OE2 . GLU A 1 429 ? 40.626 7.200 9.590 1.00 31.18 ? 429 GLU A OE2 1 ATOM 3304 N N . GLU A 1 430 ? 41.169 6.638 15.709 1.00 15.61 ? 430 GLU A N 1 ATOM 3305 C CA . GLU A 1 430 ? 41.157 7.369 16.938 1.00 14.76 ? 430 GLU A CA 1 ATOM 3306 C C . GLU A 1 430 ? 40.155 8.512 16.791 1.00 14.13 ? 430 GLU A C 1 ATOM 3307 O O . GLU A 1 430 ? 39.866 9.004 15.711 1.00 14.04 ? 430 GLU A O 1 ATOM 3308 C CB . GLU A 1 430 ? 42.564 7.871 17.252 1.00 14.31 ? 430 GLU A CB 1 ATOM 3309 C CG . GLU A 1 430 ? 42.692 8.680 18.521 1.00 14.21 ? 430 GLU A CG 1 ATOM 3310 C CD . GLU A 1 430 ? 42.645 10.177 18.298 1.00 13.54 ? 430 GLU A CD 1 ATOM 3311 O OE1 . GLU A 1 430 ? 42.213 10.633 17.207 1.00 13.62 ? 430 GLU A OE1 1 ATOM 3312 O OE2 . GLU A 1 430 ? 43.058 10.900 19.224 1.00 11.28 ? 430 GLU A OE2 1 ATOM 3313 N N . THR A 1 431 ? 39.612 8.901 17.919 1.00 14.06 ? 431 THR A N 1 ATOM 3314 C CA . THR A 1 431 ? 38.454 9.739 17.963 1.00 14.25 ? 431 THR A CA 1 ATOM 3315 C C . THR A 1 431 ? 38.911 11.195 18.249 1.00 14.07 ? 431 THR A C 1 ATOM 3316 O O . THR A 1 431 ? 39.920 11.418 18.934 1.00 14.35 ? 431 THR A O 1 ATOM 3317 C CB . THR A 1 431 ? 37.627 9.101 19.080 1.00 14.98 ? 431 THR A CB 1 ATOM 3318 O OG1 . THR A 1 431 ? 36.336 8.710 18.623 1.00 17.43 ? 431 THR A OG1 1 ATOM 3319 C CG2 . THR A 1 431 ? 37.483 9.953 20.257 1.00 11.26 ? 431 THR A CG2 1 ATOM 3320 N N . HIS A 1 432 ? 38.182 12.184 17.725 1.00 13.88 ? 432 HIS A N 1 ATOM 3321 C CA . HIS A 1 432 ? 38.351 13.567 18.170 1.00 13.06 ? 432 HIS A CA 1 ATOM 3322 C C . HIS A 1 432 ? 38.152 13.646 19.684 1.00 12.81 ? 432 HIS A C 1 ATOM 3323 O O . HIS A 1 432 ? 37.604 12.727 20.297 1.00 11.51 ? 432 HIS A O 1 ATOM 3324 C CB . HIS A 1 432 ? 37.334 14.496 17.509 1.00 13.28 ? 432 HIS A CB 1 ATOM 3325 C CG . HIS A 1 432 ? 37.459 14.588 16.020 1.00 12.86 ? 432 HIS A CG 1 ATOM 3326 N ND1 . HIS A 1 432 ? 36.489 15.171 15.236 1.00 12.87 ? 432 HIS A ND1 1 ATOM 3327 C CD2 . HIS A 1 432 ? 38.420 14.158 15.172 1.00 12.98 ? 432 HIS A CD2 1 ATOM 3328 C CE1 . HIS A 1 432 ? 36.854 15.107 13.968 1.00 12.34 ? 432 HIS A CE1 1 ATOM 3329 N NE2 . HIS A 1 432 ? 38.027 14.504 13.902 1.00 12.75 ? 432 HIS A NE2 1 ATOM 3330 N N . ALA A 1 433 ? 38.584 14.759 20.275 1.00 13.10 ? 433 ALA A N 1 ATOM 3331 C CA . ALA A 1 433 ? 38.343 15.045 21.697 1.00 12.37 ? 433 ALA A CA 1 ATOM 3332 C C . ALA A 1 433 ? 37.599 16.350 21.836 1.00 12.36 ? 433 ALA A C 1 ATOM 3333 O O . ALA A 1 433 ? 37.646 17.186 20.939 1.00 11.98 ? 433 ALA A O 1 ATOM 3334 C CB . ALA A 1 433 ? 39.630 15.089 22.478 1.00 12.51 ? 433 ALA A CB 1 ATOM 3335 N N . GLY A 1 434 ? 36.890 16.502 22.956 1.00 11.64 ? 434 GLY A N 1 ATOM 3336 C CA . GLY A 1 434 ? 35.936 17.576 23.129 1.00 11.95 ? 434 GLY A CA 1 ATOM 3337 C C . GLY A 1 434 ? 36.427 18.738 23.970 1.00 12.00 ? 434 GLY A C 1 ATOM 3338 O O . GLY A 1 434 ? 35.673 19.688 24.195 1.00 13.11 ? 434 GLY A O 1 ATOM 3339 N N . GLU A 1 435 ? 37.672 18.690 24.436 1.00 12.42 ? 435 GLU A N 1 ATOM 3340 C CA . GLU A 1 435 ? 38.161 19.749 25.310 1.00 12.61 ? 435 GLU A CA 1 ATOM 3341 C C . GLU A 1 435 ? 38.477 20.999 24.506 1.00 12.55 ? 435 GLU A C 1 ATOM 3342 O O . GLU A 1 435 ? 38.623 20.954 23.273 1.00 11.79 ? 435 GLU A O 1 ATOM 3343 C CB . GLU A 1 435 ? 39.340 19.298 26.192 1.00 13.21 ? 435 GLU A CB 1 ATOM 3344 C CG . GLU A 1 435 ? 40.745 19.411 25.614 1.00 14.06 ? 435 GLU A CG 1 ATOM 3345 C CD . GLU A 1 435 ? 41.077 18.391 24.551 1.00 15.43 ? 435 GLU A CD 1 ATOM 3346 O OE1 . GLU A 1 435 ? 40.189 17.593 24.177 1.00 15.21 ? 435 GLU A OE1 1 ATOM 3347 O OE2 . GLU A 1 435 ? 42.254 18.404 24.081 1.00 16.26 ? 435 GLU A OE2 1 ATOM 3348 N N . ASP A 1 436 ? 38.532 22.113 25.223 1.00 12.37 ? 436 ASP A N 1 ATOM 3349 C CA . ASP A 1 436 ? 38.792 23.409 24.620 1.00 13.09 ? 436 ASP A CA 1 ATOM 3350 C C . ASP A 1 436 ? 40.119 23.381 23.899 1.00 12.79 ? 436 ASP A C 1 ATOM 3351 O O . ASP A 1 436 ? 41.084 22.718 24.323 1.00 11.70 ? 436 ASP A O 1 ATOM 3352 C CB . ASP A 1 436 ? 38.869 24.511 25.657 1.00 13.21 ? 436 ASP A CB 1 ATOM 3353 C CG . ASP A 1 436 ? 37.650 24.591 26.528 1.00 14.05 ? 436 ASP A CG 1 ATOM 3354 O OD1 . ASP A 1 436 ? 36.600 24.018 26.178 1.00 13.94 ? 436 ASP A OD1 1 ATOM 3355 O OD2 . ASP A 1 436 ? 37.677 25.199 27.615 1.00 16.06 ? 436 ASP A OD2 1 ATOM 3356 N N . VAL A 1 437 ? 40.160 24.145 22.829 1.00 13.09 ? 437 VAL A N 1 ATOM 3357 C CA . VAL A 1 437 ? 41.373 24.332 22.075 1.00 13.53 ? 437 VAL A CA 1 ATOM 3358 C C . VAL A 1 437 ? 41.782 25.798 22.203 1.00 13.43 ? 437 VAL A C 1 ATOM 3359 O O . VAL A 1 437 ? 40.991 26.654 22.586 1.00 12.56 ? 437 VAL A O 1 ATOM 3360 C CB . VAL A 1 437 ? 41.212 23.913 20.594 1.00 13.72 ? 437 VAL A CB 1 ATOM 3361 C CG1 . VAL A 1 437 ? 40.864 22.443 20.496 1.00 13.63 ? 437 VAL A CG1 1 ATOM 3362 C CG2 . VAL A 1 437 ? 40.157 24.782 19.870 1.00 14.67 ? 437 VAL A CG2 1 ATOM 3363 N N . ALA A 1 438 ? 43.028 26.066 21.859 1.00 12.78 ? 438 ALA A N 1 ATOM 3364 C CA . ALA A 1 438 ? 43.545 27.407 21.895 1.00 13.50 ? 438 ALA A CA 1 ATOM 3365 C C . ALA A 1 438 ? 43.120 28.210 20.677 1.00 13.59 ? 438 ALA A C 1 ATOM 3366 O O . ALA A 1 438 ? 42.878 27.659 19.583 1.00 13.19 ? 438 ALA A O 1 ATOM 3367 C CB . ALA A 1 438 ? 45.077 27.374 21.985 1.00 13.74 ? 438 ALA A CB 1 ATOM 3368 N N . VAL A 1 439 ? 43.028 29.522 20.889 1.00 13.60 ? 439 VAL A N 1 ATOM 3369 C CA . VAL A 1 439 ? 43.005 30.499 19.808 1.00 13.78 ? 439 VAL A CA 1 ATOM 3370 C C . VAL A 1 439 ? 44.189 31.392 20.083 1.00 13.54 ? 439 VAL A C 1 ATOM 3371 O O . VAL A 1 439 ? 44.315 31.903 21.195 1.00 14.07 ? 439 VAL A O 1 ATOM 3372 C CB . VAL A 1 439 ? 41.738 31.371 19.796 1.00 14.22 ? 439 VAL A CB 1 ATOM 3373 C CG1 . VAL A 1 439 ? 41.725 32.295 18.562 1.00 13.67 ? 439 VAL A CG1 1 ATOM 3374 C CG2 . VAL A 1 439 ? 40.502 30.518 19.809 1.00 15.65 ? 439 VAL A CG2 1 ATOM 3375 N N . PHE A 1 440 ? 45.082 31.521 19.110 1.00 12.77 ? 440 PHE A N 1 ATOM 3376 C CA . PHE A 1 440 ? 46.178 32.486 19.178 1.00 13.48 ? 440 PHE A CA 1 ATOM 3377 C C . PHE A 1 440 ? 45.896 33.607 18.205 1.00 13.72 ? 440 PHE A C 1 ATOM 3378 O O . PHE A 1 440 ? 45.448 33.351 17.084 1.00 13.25 ? 440 PHE A O 1 ATOM 3379 C CB . PHE A 1 440 ? 47.520 31.885 18.772 1.00 13.39 ? 440 PHE A CB 1 ATOM 3380 C CG . PHE A 1 440 ? 47.868 30.604 19.465 1.00 14.95 ? 440 PHE A CG 1 ATOM 3381 C CD1 . PHE A 1 440 ? 47.346 29.409 19.022 1.00 14.15 ? 440 PHE A CD1 1 ATOM 3382 C CD2 . PHE A 1 440 ? 48.756 30.588 20.519 1.00 15.13 ? 440 PHE A CD2 1 ATOM 3383 C CE1 . PHE A 1 440 ? 47.688 28.224 19.613 1.00 15.65 ? 440 PHE A CE1 1 ATOM 3384 C CE2 . PHE A 1 440 ? 49.098 29.386 21.132 1.00 16.35 ? 440 PHE A CE2 1 ATOM 3385 C CZ . PHE A 1 440 ? 48.564 28.209 20.670 1.00 14.47 ? 440 PHE A CZ 1 ATOM 3386 N N . ALA A 1 441 ? 46.231 34.837 18.589 1.00 13.96 ? 441 ALA A N 1 ATOM 3387 C CA . ALA A 1 441 ? 45.873 35.984 17.773 1.00 13.99 ? 441 ALA A CA 1 ATOM 3388 C C . ALA A 1 441 ? 46.910 37.109 17.811 1.00 14.62 ? 441 ALA A C 1 ATOM 3389 O O . ALA A 1 441 ? 47.451 37.435 18.856 1.00 14.96 ? 441 ALA A O 1 ATOM 3390 C CB . ALA A 1 441 ? 44.523 36.507 18.198 1.00 14.27 ? 441 ALA A CB 1 ATOM 3391 N N . ARG A 1 442 ? 47.154 37.694 16.650 1.00 14.75 ? 442 ARG A N 1 ATOM 3392 C CA . ARG A 1 442 ? 48.000 38.879 16.520 1.00 15.87 ? 442 ARG A CA 1 ATOM 3393 C C . ARG A 1 442 ? 47.428 39.755 15.415 1.00 15.33 ? 442 ARG A C 1 ATOM 3394 O O . ARG A 1 442 ? 46.748 39.265 14.494 1.00 15.12 ? 442 ARG A O 1 ATOM 3395 C CB . ARG A 1 442 ? 49.464 38.505 16.245 1.00 15.80 ? 442 ARG A CB 1 ATOM 3396 C CG . ARG A 1 442 ? 49.779 38.094 14.828 1.00 17.84 ? 442 ARG A CG 1 ATOM 3397 C CD . ARG A 1 442 ? 51.257 38.243 14.438 1.00 18.29 ? 442 ARG A CD 1 ATOM 3398 N NE . ARG A 1 442 ? 52.139 37.337 15.158 1.00 20.58 ? 442 ARG A NE 1 ATOM 3399 C CZ . ARG A 1 442 ? 53.000 37.680 16.129 1.00 21.20 ? 442 ARG A CZ 1 ATOM 3400 N NH1 . ARG A 1 442 ? 53.756 36.745 16.681 1.00 21.35 ? 442 ARG A NH1 1 ATOM 3401 N NH2 . ARG A 1 442 ? 53.121 38.927 16.558 1.00 22.50 ? 442 ARG A NH2 1 ATOM 3402 N N . GLY A 1 443 ? 47.679 41.052 15.529 1.00 15.19 ? 443 GLY A N 1 ATOM 3403 C CA . GLY A 1 443 ? 47.208 42.006 14.560 1.00 15.67 ? 443 GLY A CA 1 ATOM 3404 C C . GLY A 1 443 ? 46.094 42.878 15.066 1.00 15.93 ? 443 GLY A C 1 ATOM 3405 O O . GLY A 1 443 ? 45.737 42.842 16.256 1.00 15.99 ? 443 GLY A O 1 ATOM 3406 N N . PRO A 1 444 ? 45.533 43.685 14.164 1.00 16.40 ? 444 PRO A N 1 ATOM 3407 C CA . PRO A 1 444 ? 44.519 44.661 14.553 1.00 16.50 ? 444 PRO A CA 1 ATOM 3408 C C . PRO A 1 444 ? 43.287 43.968 15.141 1.00 16.27 ? 444 PRO A C 1 ATOM 3409 O O . PRO A 1 444 ? 42.736 43.063 14.511 1.00 16.05 ? 444 PRO A O 1 ATOM 3410 C CB . PRO A 1 444 ? 44.193 45.360 13.228 1.00 16.48 ? 444 PRO A CB 1 ATOM 3411 C CG . PRO A 1 444 ? 45.386 45.108 12.376 1.00 17.02 ? 444 PRO A CG 1 ATOM 3412 C CD . PRO A 1 444 ? 45.788 43.721 12.712 1.00 16.15 ? 444 PRO A CD 1 ATOM 3413 N N . GLN A 1 445 ? 42.896 44.395 16.344 1.00 15.84 ? 445 GLN A N 1 ATOM 3414 C CA . GLN A 1 445 ? 41.780 43.818 17.120 1.00 15.83 ? 445 GLN A CA 1 ATOM 3415 C C . GLN A 1 445 ? 42.022 42.414 17.711 1.00 15.39 ? 445 GLN A C 1 ATOM 3416 O O . GLN A 1 445 ? 41.112 41.819 18.282 1.00 14.93 ? 445 GLN A O 1 ATOM 3417 C CB . GLN A 1 445 ? 40.468 43.849 16.327 1.00 16.04 ? 445 GLN A CB 1 ATOM 3418 C CG . GLN A 1 445 ? 40.142 45.197 15.692 1.00 15.75 ? 445 GLN A CG 1 ATOM 3419 C CD . GLN A 1 445 ? 40.307 46.368 16.646 1.00 17.53 ? 445 GLN A CD 1 ATOM 3420 O OE1 . GLN A 1 445 ? 41.067 47.312 16.359 1.00 20.50 ? 445 GLN A OE1 1 ATOM 3421 N NE2 . GLN A 1 445 ? 39.617 46.319 17.778 1.00 16.09 ? 445 GLN A NE2 1 ATOM 3422 N N . ALA A 1 446 ? 43.253 41.917 17.613 1.00 14.97 ? 446 ALA A N 1 ATOM 3423 C CA . ALA A 1 446 ? 43.645 40.633 18.207 1.00 14.63 ? 446 ALA A CA 1 ATOM 3424 C C . ALA A 1 446 ? 43.424 40.599 19.730 1.00 14.65 ? 446 ALA A C 1 ATOM 3425 O O . ALA A 1 446 ? 43.108 39.548 20.290 1.00 14.72 ? 446 ALA A O 1 ATOM 3426 C CB . ALA A 1 446 ? 45.097 40.340 17.885 1.00 13.75 ? 446 ALA A CB 1 ATOM 3427 N N . HIS A 1 447 ? 43.573 41.747 20.387 1.00 15.44 ? 447 HIS A N 1 ATOM 3428 C CA . HIS A 1 447 ? 43.323 41.848 21.824 1.00 15.47 ? 447 HIS A CA 1 ATOM 3429 C C . HIS A 1 447 ? 41.903 41.442 22.210 1.00 15.79 ? 447 HIS A C 1 ATOM 3430 O O . HIS A 1 447 ? 41.658 41.081 23.356 1.00 16.04 ? 447 HIS A O 1 ATOM 3431 C CB . HIS A 1 447 ? 43.624 43.265 22.323 1.00 16.20 ? 447 HIS A CB 1 ATOM 3432 C CG . HIS A 1 447 ? 42.612 44.281 21.895 1.00 17.29 ? 447 HIS A CG 1 ATOM 3433 N ND1 . HIS A 1 447 ? 42.612 44.849 20.639 1.00 19.26 ? 447 HIS A ND1 1 ATOM 3434 C CD2 . HIS A 1 447 ? 41.581 44.847 22.565 1.00 18.76 ? 447 HIS A CD2 1 ATOM 3435 C CE1 . HIS A 1 447 ? 41.607 45.703 20.547 1.00 19.37 ? 447 HIS A CE1 1 ATOM 3436 N NE2 . HIS A 1 447 ? 40.971 45.725 21.703 1.00 18.29 ? 447 HIS A NE2 1 ATOM 3437 N N . LEU A 1 448 ? 40.959 41.509 21.269 1.00 15.56 ? 448 LEU A N 1 ATOM 3438 C CA . LEU A 1 448 ? 39.596 41.048 21.534 1.00 15.90 ? 448 LEU A CA 1 ATOM 3439 C C . LEU A 1 448 ? 39.492 39.541 21.738 1.00 15.61 ? 448 LEU A C 1 ATOM 3440 O O . LEU A 1 448 ? 38.522 39.048 22.329 1.00 15.91 ? 448 LEU A O 1 ATOM 3441 C CB . LEU A 1 448 ? 38.655 41.480 20.414 1.00 16.22 ? 448 LEU A CB 1 ATOM 3442 C CG . LEU A 1 448 ? 38.557 42.995 20.179 1.00 17.07 ? 448 LEU A CG 1 ATOM 3443 C CD1 . LEU A 1 448 ? 37.514 43.253 19.118 1.00 16.96 ? 448 LEU A CD1 1 ATOM 3444 C CD2 . LEU A 1 448 ? 38.246 43.736 21.464 1.00 17.84 ? 448 LEU A CD2 1 ATOM 3445 N N . VAL A 1 449 ? 40.493 38.814 21.252 1.00 15.36 ? 449 VAL A N 1 ATOM 3446 C CA . VAL A 1 449 ? 40.584 37.383 21.460 1.00 14.78 ? 449 VAL A CA 1 ATOM 3447 C C . VAL A 1 449 ? 41.083 37.161 22.883 1.00 14.84 ? 449 VAL A C 1 ATOM 3448 O O . VAL A 1 449 ? 42.268 37.361 23.181 1.00 14.64 ? 449 VAL A O 1 ATOM 3449 C CB . VAL A 1 449 ? 41.526 36.724 20.412 1.00 14.60 ? 449 VAL A CB 1 ATOM 3450 C CG1 . VAL A 1 449 ? 41.681 35.237 20.673 1.00 14.19 ? 449 VAL A CG1 1 ATOM 3451 C CG2 . VAL A 1 449 ? 40.983 36.954 18.995 1.00 14.11 ? 449 VAL A CG2 1 ATOM 3452 N N . HIS A 1 450 ? 40.164 36.781 23.762 1.00 14.51 ? 450 HIS A N 1 ATOM 3453 C CA . HIS A 1 450 ? 40.442 36.704 25.190 1.00 14.97 ? 450 HIS A CA 1 ATOM 3454 C C . HIS A 1 450 ? 39.506 35.726 25.885 1.00 14.64 ? 450 HIS A C 1 ATOM 3455 O O . HIS A 1 450 ? 38.422 35.405 25.382 1.00 14.29 ? 450 HIS A O 1 ATOM 3456 C CB . HIS A 1 450 ? 40.288 38.085 25.841 1.00 14.99 ? 450 HIS A CB 1 ATOM 3457 C CG . HIS A 1 450 ? 38.880 38.388 26.275 1.00 15.90 ? 450 HIS A CG 1 ATOM 3458 N ND1 . HIS A 1 450 ? 37.905 38.819 25.399 1.00 18.69 ? 450 HIS A ND1 1 ATOM 3459 C CD2 . HIS A 1 450 ? 38.274 38.262 27.473 1.00 16.75 ? 450 HIS A CD2 1 ATOM 3460 C CE1 . HIS A 1 450 ? 36.762 38.960 26.048 1.00 17.04 ? 450 HIS A CE1 1 ATOM 3461 N NE2 . HIS A 1 450 ? 36.960 38.638 27.311 1.00 18.20 ? 450 HIS A NE2 1 ATOM 3462 N N . GLY A 1 451 ? 39.930 35.263 27.055 1.00 14.72 ? 451 GLY A N 1 ATOM 3463 C CA . GLY A 1 451 ? 39.091 34.455 27.909 1.00 14.39 ? 451 GLY A CA 1 ATOM 3464 C C . GLY A 1 451 ? 38.712 33.119 27.309 1.00 14.48 ? 451 GLY A C 1 ATOM 3465 O O . GLY A 1 451 ? 39.479 32.526 26.556 1.00 13.74 ? 451 GLY A O 1 ATOM 3466 N N . VAL A 1 452 ? 37.515 32.669 27.665 1.00 14.01 ? 452 VAL A N 1 ATOM 3467 C CA . VAL A 1 452 ? 36.949 31.415 27.210 1.00 14.16 ? 452 VAL A CA 1 ATOM 3468 C C . VAL A 1 452 ? 35.746 31.788 26.361 1.00 14.07 ? 452 VAL A C 1 ATOM 3469 O O . VAL A 1 452 ? 34.842 32.488 26.822 1.00 13.65 ? 452 VAL A O 1 ATOM 3470 C CB . VAL A 1 452 ? 36.510 30.543 28.382 1.00 14.21 ? 452 VAL A CB 1 ATOM 3471 C CG1 . VAL A 1 452 ? 35.980 29.189 27.905 1.00 15.68 ? 452 VAL A CG1 1 ATOM 3472 C CG2 . VAL A 1 452 ? 37.666 30.392 29.377 1.00 15.47 ? 452 VAL A CG2 1 ATOM 3473 N N . GLN A 1 453 ? 35.765 31.358 25.108 1.00 13.70 ? 453 GLN A N 1 ATOM 3474 C CA . GLN A 1 453 ? 34.760 31.777 24.159 1.00 14.33 ? 453 GLN A CA 1 ATOM 3475 C C . GLN A 1 453 ? 34.174 30.566 23.459 1.00 14.38 ? 453 GLN A C 1 ATOM 3476 O O . GLN A 1 453 ? 34.809 29.521 23.355 1.00 13.99 ? 453 GLN A O 1 ATOM 3477 C CB . GLN A 1 453 ? 35.369 32.699 23.106 1.00 14.72 ? 453 GLN A CB 1 ATOM 3478 C CG . GLN A 1 453 ? 36.025 33.931 23.641 1.00 16.72 ? 453 GLN A CG 1 ATOM 3479 C CD . GLN A 1 453 ? 35.045 34.925 24.205 1.00 19.95 ? 453 GLN A CD 1 ATOM 3480 O OE1 . GLN A 1 453 ? 33.822 34.800 24.024 1.00 21.19 ? 453 GLN A OE1 1 ATOM 3481 N NE2 . GLN A 1 453 ? 35.570 35.922 24.888 1.00 22.05 ? 453 GLN A NE2 1 ATOM 3482 N N . GLU A 1 454 ? 32.956 30.730 22.970 1.00 14.63 ? 454 GLU A N 1 ATOM 3483 C CA . GLU A 1 454 ? 32.412 29.828 21.991 1.00 14.00 ? 454 GLU A CA 1 ATOM 3484 C C . GLU A 1 454 ? 33.246 29.958 20.728 1.00 13.23 ? 454 GLU A C 1 ATOM 3485 O O . GLU A 1 454 ? 33.767 31.020 20.419 1.00 12.54 ? 454 GLU A O 1 ATOM 3486 C CB . GLU A 1 454 ? 30.959 30.176 21.677 1.00 14.29 ? 454 GLU A CB 1 ATOM 3487 C CG . GLU A 1 454 ? 29.998 29.927 22.820 1.00 15.05 ? 454 GLU A CG 1 ATOM 3488 C CD . GLU A 1 454 ? 29.659 28.475 23.013 1.00 15.67 ? 454 GLU A CD 1 ATOM 3489 O OE1 . GLU A 1 454 ? 30.153 27.601 22.240 1.00 14.23 ? 454 GLU A OE1 1 ATOM 3490 O OE2 . GLU A 1 454 ? 28.867 28.207 23.943 1.00 16.30 ? 454 GLU A OE2 1 ATOM 3491 N N . GLN A 1 455 ? 33.354 28.855 20.001 1.00 13.39 ? 455 GLN A N 1 ATOM 3492 C CA . GLN A 1 455 ? 34.177 28.786 18.795 1.00 13.34 ? 455 GLN A CA 1 ATOM 3493 C C . GLN A 1 455 ? 33.722 29.769 17.730 1.00 13.45 ? 455 GLN A C 1 ATOM 3494 O O . GLN A 1 455 ? 34.519 30.258 16.938 1.00 12.92 ? 455 GLN A O 1 ATOM 3495 C CB . GLN A 1 455 ? 34.139 27.370 18.241 1.00 13.93 ? 455 GLN A CB 1 ATOM 3496 C CG . GLN A 1 455 ? 35.136 27.142 17.124 1.00 13.22 ? 455 GLN A CG 1 ATOM 3497 C CD . GLN A 1 455 ? 35.288 25.694 16.795 1.00 12.89 ? 455 GLN A CD 1 ATOM 3498 O OE1 . GLN A 1 455 ? 36.417 25.181 16.724 1.00 14.86 ? 455 GLN A OE1 1 ATOM 3499 N NE2 . GLN A 1 455 ? 34.167 25.012 16.604 1.00 9.99 ? 455 GLN A NE2 1 ATOM 3500 N N . THR A 1 456 ? 32.426 30.051 17.725 1.00 13.41 ? 456 THR A N 1 ATOM 3501 C CA . THR A 1 456 ? 31.834 31.049 16.832 1.00 13.59 ? 456 THR A CA 1 ATOM 3502 C C . THR A 1 456 ? 32.514 32.399 16.928 1.00 13.73 ? 456 THR A C 1 ATOM 3503 O O . THR A 1 456 ? 32.499 33.163 15.954 1.00 14.04 ? 456 THR A O 1 ATOM 3504 C CB . THR A 1 456 ? 30.344 31.237 17.158 1.00 12.89 ? 456 THR A CB 1 ATOM 3505 O OG1 . THR A 1 456 ? 30.191 31.374 18.573 1.00 13.45 ? 456 THR A OG1 1 ATOM 3506 C CG2 . THR A 1 456 ? 29.532 30.010 16.805 1.00 12.43 ? 456 THR A CG2 1 ATOM 3507 N N . PHE A 1 457 ? 33.046 32.715 18.114 1.00 14.44 ? 457 PHE A N 1 ATOM 3508 C CA . PHE A 1 457 ? 33.757 33.978 18.350 1.00 14.54 ? 457 PHE A CA 1 ATOM 3509 C C . PHE A 1 457 ? 34.865 34.241 17.319 1.00 14.35 ? 457 PHE A C 1 ATOM 3510 O O . PHE A 1 457 ? 35.092 35.373 16.924 1.00 13.03 ? 457 PHE A O 1 ATOM 3511 C CB . PHE A 1 457 ? 34.340 34.016 19.762 1.00 14.94 ? 457 PHE A CB 1 ATOM 3512 C CG . PHE A 1 457 ? 34.851 35.361 20.168 1.00 15.51 ? 457 PHE A CG 1 ATOM 3513 C CD1 . PHE A 1 457 ? 33.978 36.325 20.665 1.00 16.12 ? 457 PHE A CD1 1 ATOM 3514 C CD2 . PHE A 1 457 ? 36.194 35.683 20.022 1.00 16.12 ? 457 PHE A CD2 1 ATOM 3515 C CE1 . PHE A 1 457 ? 34.457 37.591 21.041 1.00 17.24 ? 457 PHE A CE1 1 ATOM 3516 C CE2 . PHE A 1 457 ? 36.683 36.921 20.406 1.00 15.63 ? 457 PHE A CE2 1 ATOM 3517 C CZ . PHE A 1 457 ? 35.811 37.883 20.911 1.00 17.67 ? 457 PHE A CZ 1 ATOM 3518 N N . ILE A 1 458 ? 35.530 33.178 16.879 1.00 14.51 ? 458 ILE A N 1 ATOM 3519 C CA . ILE A 1 458 ? 36.593 33.285 15.880 1.00 14.67 ? 458 ILE A CA 1 ATOM 3520 C C . ILE A 1 458 ? 36.093 33.963 14.597 1.00 14.37 ? 458 ILE A C 1 ATOM 3521 O O . ILE A 1 458 ? 36.758 34.858 14.071 1.00 14.44 ? 458 ILE A O 1 ATOM 3522 C CB . ILE A 1 458 ? 37.178 31.886 15.608 1.00 14.54 ? 458 ILE A CB 1 ATOM 3523 C CG1 . ILE A 1 458 ? 37.995 31.440 16.826 1.00 13.80 ? 458 ILE A CG1 1 ATOM 3524 C CG2 . ILE A 1 458 ? 38.040 31.866 14.331 1.00 15.51 ? 458 ILE A CG2 1 ATOM 3525 C CD1 . ILE A 1 458 ? 37.921 29.973 17.102 1.00 14.67 ? 458 ILE A CD1 1 ATOM 3526 N N . ALA A 1 459 ? 34.938 33.532 14.094 1.00 14.61 ? 459 ALA A N 1 ATOM 3527 C CA . ALA A 1 459 ? 34.386 34.126 12.881 1.00 14.64 ? 459 ALA A CA 1 ATOM 3528 C C . ALA A 1 459 ? 34.048 35.581 13.133 1.00 14.67 ? 459 ALA A C 1 ATOM 3529 O O . ALA A 1 459 ? 34.368 36.443 12.309 1.00 14.75 ? 459 ALA A O 1 ATOM 3530 C CB . ALA A 1 459 ? 33.147 33.376 12.412 1.00 14.52 ? 459 ALA A CB 1 ATOM 3531 N N . HIS A 1 460 ? 33.384 35.842 14.262 1.00 14.87 ? 460 HIS A N 1 ATOM 3532 C CA . HIS A 1 460 ? 32.875 37.186 14.553 1.00 15.26 ? 460 HIS A CA 1 ATOM 3533 C C . HIS A 1 460 ? 33.976 38.220 14.780 1.00 15.40 ? 460 HIS A C 1 ATOM 3534 O O . HIS A 1 460 ? 33.858 39.374 14.321 1.00 15.79 ? 460 HIS A O 1 ATOM 3535 C CB . HIS A 1 460 ? 31.904 37.156 15.737 1.00 15.37 ? 460 HIS A CB 1 ATOM 3536 C CG . HIS A 1 460 ? 30.556 36.597 15.385 1.00 15.31 ? 460 HIS A CG 1 ATOM 3537 N ND1 . HIS A 1 460 ? 29.495 37.392 15.015 1.00 15.30 ? 460 HIS A ND1 1 ATOM 3538 C CD2 . HIS A 1 460 ? 30.111 35.321 15.318 1.00 13.68 ? 460 HIS A CD2 1 ATOM 3539 C CE1 . HIS A 1 460 ? 28.449 36.633 14.759 1.00 15.11 ? 460 HIS A CE1 1 ATOM 3540 N NE2 . HIS A 1 460 ? 28.794 35.370 14.935 1.00 14.27 ? 460 HIS A NE2 1 ATOM 3541 N N . VAL A 1 461 ? 35.042 37.831 15.475 1.00 15.23 ? 461 VAL A N 1 ATOM 3542 C CA . VAL A 1 461 ? 36.121 38.784 15.721 1.00 15.07 ? 461 VAL A CA 1 ATOM 3543 C C . VAL A 1 461 ? 36.808 39.132 14.408 1.00 15.19 ? 461 VAL A C 1 ATOM 3544 O O . VAL A 1 461 ? 37.212 40.268 14.205 1.00 14.57 ? 461 VAL A O 1 ATOM 3545 C CB . VAL A 1 461 ? 37.129 38.296 16.789 1.00 15.46 ? 461 VAL A CB 1 ATOM 3546 C CG1 . VAL A 1 461 ? 38.037 37.194 16.261 1.00 15.73 ? 461 VAL A CG1 1 ATOM 3547 C CG2 . VAL A 1 461 ? 37.966 39.467 17.290 1.00 15.86 ? 461 VAL A CG2 1 ATOM 3548 N N . MET A 1 462 ? 36.931 38.151 13.513 1.00 15.71 ? 462 MET A N 1 ATOM 3549 C CA . MET A 1 462 ? 37.571 38.387 12.230 1.00 16.79 ? 462 MET A CA 1 ATOM 3550 C C . MET A 1 462 ? 36.702 39.292 11.380 1.00 16.40 ? 462 MET A C 1 ATOM 3551 O O . MET A 1 462 ? 37.194 40.256 10.794 1.00 16.83 ? 462 MET A O 1 ATOM 3552 C CB . MET A 1 462 ? 37.850 37.065 11.523 1.00 16.25 ? 462 MET A CB 1 ATOM 3553 C CG . MET A 1 462 ? 38.944 36.269 12.207 1.00 18.08 ? 462 MET A CG 1 ATOM 3554 S SD . MET A 1 462 ? 39.257 34.724 11.337 1.00 18.48 ? 462 MET A SD 1 ATOM 3555 C CE . MET A 1 462 ? 40.047 35.315 9.861 1.00 18.87 ? 462 MET A CE 1 ATOM 3556 N N . ALA A 1 463 ? 35.400 39.003 11.338 1.00 16.59 ? 463 ALA A N 1 ATOM 3557 C CA . ALA A 1 463 ? 34.470 39.871 10.615 1.00 16.27 ? 463 ALA A CA 1 ATOM 3558 C C . ALA A 1 463 ? 34.475 41.286 11.191 1.00 16.13 ? 463 ALA A C 1 ATOM 3559 O O . ALA A 1 463 ? 34.541 42.278 10.454 1.00 16.42 ? 463 ALA A O 1 ATOM 3560 C CB . ALA A 1 463 ? 33.067 39.296 10.650 1.00 16.28 ? 463 ALA A CB 1 ATOM 3561 N N . PHE A 1 464 ? 34.412 41.376 12.511 1.00 16.49 ? 464 PHE A N 1 ATOM 3562 C CA . PHE A 1 464 ? 34.455 42.670 13.179 1.00 16.45 ? 464 PHE A CA 1 ATOM 3563 C C . PHE A 1 464 ? 35.722 43.444 12.850 1.00 16.40 ? 464 PHE A C 1 ATOM 3564 O O . PHE A 1 464 ? 35.669 44.634 12.547 1.00 16.22 ? 464 PHE A O 1 ATOM 3565 C CB . PHE A 1 464 ? 34.372 42.515 14.702 1.00 17.27 ? 464 PHE A CB 1 ATOM 3566 C CG . PHE A 1 464 ? 34.659 43.792 15.435 1.00 18.29 ? 464 PHE A CG 1 ATOM 3567 C CD1 . PHE A 1 464 ? 33.680 44.774 15.543 1.00 19.91 ? 464 PHE A CD1 1 ATOM 3568 C CD2 . PHE A 1 464 ? 35.920 44.050 15.948 1.00 19.35 ? 464 PHE A CD2 1 ATOM 3569 C CE1 . PHE A 1 464 ? 33.946 45.975 16.197 1.00 20.94 ? 464 PHE A CE1 1 ATOM 3570 C CE2 . PHE A 1 464 ? 36.197 45.254 16.591 1.00 19.87 ? 464 PHE A CE2 1 ATOM 3571 C CZ . PHE A 1 464 ? 35.210 46.215 16.717 1.00 20.22 ? 464 PHE A CZ 1 ATOM 3572 N N . ALA A 1 465 ? 36.867 42.766 12.940 1.00 15.66 ? 465 ALA A N 1 ATOM 3573 C CA . ALA A 1 465 ? 38.160 43.416 12.779 1.00 16.15 ? 465 ALA A CA 1 ATOM 3574 C C . ALA A 1 465 ? 38.296 44.031 11.393 1.00 16.39 ? 465 ALA A C 1 ATOM 3575 O O . ALA A 1 465 ? 38.940 45.056 11.227 1.00 16.34 ? 465 ALA A O 1 ATOM 3576 C CB . ALA A 1 465 ? 39.297 42.414 13.026 1.00 16.16 ? 465 ALA A CB 1 ATOM 3577 N N . ALA A 1 466 ? 37.699 43.382 10.401 1.00 16.93 ? 466 ALA A N 1 ATOM 3578 C CA . ALA A 1 466 ? 37.787 43.821 9.017 1.00 17.78 ? 466 ALA A CA 1 ATOM 3579 C C . ALA A 1 466 ? 36.595 44.702 8.623 1.00 18.76 ? 466 ALA A C 1 ATOM 3580 O O . ALA A 1 466 ? 36.487 45.135 7.474 1.00 18.93 ? 466 ALA A O 1 ATOM 3581 C CB . ALA A 1 466 ? 37.882 42.622 8.113 1.00 17.80 ? 466 ALA A CB 1 ATOM 3582 N N . CYS A 1 467 ? 35.706 44.960 9.577 1.00 20.21 ? 467 CYS A N 1 ATOM 3583 C CA . CYS A 1 467 ? 34.495 45.757 9.337 1.00 21.78 ? 467 CYS A CA 1 ATOM 3584 C C . CYS A 1 467 ? 33.626 45.151 8.245 1.00 21.50 ? 467 CYS A C 1 ATOM 3585 O O . CYS A 1 467 ? 33.089 45.846 7.384 1.00 21.89 ? 467 CYS A O 1 ATOM 3586 C CB . CYS A 1 467 ? 34.875 47.198 9.039 1.00 22.67 ? 467 CYS A CB 1 ATOM 3587 S SG . CYS A 1 467 ? 35.884 47.869 10.377 1.00 26.76 ? 467 CYS A SG 1 ATOM 3588 N N . LEU A 1 468 ? 33.495 43.837 8.315 1.00 21.08 ? 468 LEU A N 1 ATOM 3589 C CA . LEU A 1 468 ? 32.635 43.083 7.430 1.00 21.50 ? 468 LEU A CA 1 ATOM 3590 C C . LEU A 1 468 ? 31.341 42.717 8.110 1.00 22.15 ? 468 LEU A C 1 ATOM 3591 O O . LEU A 1 468 ? 31.152 42.957 9.305 1.00 21.17 ? 468 LEU A O 1 ATOM 3592 C CB . LEU A 1 468 ? 33.318 41.774 7.047 1.00 21.08 ? 468 LEU A CB 1 ATOM 3593 C CG . LEU A 1 468 ? 34.695 41.899 6.400 1.00 21.34 ? 468 LEU A CG 1 ATOM 3594 C CD1 . LEU A 1 468 ? 35.307 40.507 6.263 1.00 19.57 ? 468 LEU A CD1 1 ATOM 3595 C CD2 . LEU A 1 468 ? 34.583 42.601 5.048 1.00 22.15 ? 468 LEU A CD2 1 ATOM 3596 N N . GLU A 1 469 ? 30.461 42.091 7.331 1.00 23.41 ? 469 GLU A N 1 ATOM 3597 C CA . GLU A 1 469 ? 29.523 41.107 7.895 1.00 24.27 ? 469 GLU A CA 1 ATOM 3598 C C . GLU A 1 469 ? 28.588 41.936 8.678 1.00 24.93 ? 469 GLU A C 1 ATOM 3599 O O . GLU A 1 469 ? 28.314 43.039 8.201 1.00 27.39 ? 469 GLU A O 1 ATOM 3600 C CB . GLU A 1 469 ? 30.219 40.153 8.694 1.00 23.43 ? 469 GLU A CB 1 ATOM 3601 N N . PRO A 1 470 ? 28.092 41.528 9.848 1.00 24.67 ? 470 PRO A N 1 ATOM 3602 C CA . PRO A 1 470 ? 27.146 42.396 10.503 1.00 24.40 ? 470 PRO A CA 1 ATOM 3603 C C . PRO A 1 470 ? 27.855 43.518 11.262 1.00 23.64 ? 470 PRO A C 1 ATOM 3604 O O . PRO A 1 470 ? 27.215 44.224 12.027 1.00 23.79 ? 470 PRO A O 1 ATOM 3605 C CB . PRO A 1 470 ? 26.410 41.443 11.449 1.00 24.70 ? 470 PRO A CB 1 ATOM 3606 C CG . PRO A 1 470 ? 27.421 40.455 11.827 1.00 24.51 ? 470 PRO A CG 1 ATOM 3607 C CD . PRO A 1 470 ? 28.323 40.311 10.653 1.00 24.56 ? 470 PRO A CD 1 ATOM 3608 N N . TYR A 1 471 ? 29.157 43.703 11.033 1.00 23.14 ? 471 TYR A N 1 ATOM 3609 C CA . TYR A 1 471 ? 29.915 44.747 11.733 1.00 22.74 ? 471 TYR A CA 1 ATOM 3610 C C . TYR A 1 471 ? 30.491 45.807 10.791 1.00 23.62 ? 471 TYR A C 1 ATOM 3611 O O . TYR A 1 471 ? 31.595 46.308 11.003 1.00 23.24 ? 471 TYR A O 1 ATOM 3612 C CB . TYR A 1 471 ? 31.028 44.107 12.559 1.00 21.65 ? 471 TYR A CB 1 ATOM 3613 C CG . TYR A 1 471 ? 30.541 42.952 13.404 1.00 21.29 ? 471 TYR A CG 1 ATOM 3614 C CD1 . TYR A 1 471 ? 30.957 41.654 13.153 1.00 18.20 ? 471 TYR A CD1 1 ATOM 3615 C CD2 . TYR A 1 471 ? 29.662 43.163 14.456 1.00 19.68 ? 471 TYR A CD2 1 ATOM 3616 C CE1 . TYR A 1 471 ? 30.511 40.596 13.920 1.00 19.18 ? 471 TYR A CE1 1 ATOM 3617 C CE2 . TYR A 1 471 ? 29.194 42.100 15.232 1.00 20.04 ? 471 TYR A CE2 1 ATOM 3618 C CZ . TYR A 1 471 ? 29.625 40.820 14.965 1.00 19.19 ? 471 TYR A CZ 1 ATOM 3619 O OH . TYR A 1 471 ? 29.165 39.771 15.732 1.00 18.45 ? 471 TYR A OH 1 ATOM 3620 N N . THR A 1 472 ? 29.737 46.174 9.758 1.00 24.68 ? 472 THR A N 1 ATOM 3621 C CA . THR A 1 472 ? 30.188 47.247 8.868 1.00 25.68 ? 472 THR A CA 1 ATOM 3622 C C . THR A 1 472 ? 30.285 48.550 9.630 1.00 26.73 ? 472 THR A C 1 ATOM 3623 O O . THR A 1 472 ? 31.127 49.378 9.321 1.00 27.28 ? 472 THR A O 1 ATOM 3624 C CB . THR A 1 472 ? 29.272 47.427 7.651 1.00 25.66 ? 472 THR A CB 1 ATOM 3625 O OG1 . THR A 1 472 ? 27.908 47.573 8.072 1.00 26.10 ? 472 THR A OG1 1 ATOM 3626 C CG2 . THR A 1 472 ? 29.298 46.205 6.787 1.00 24.88 ? 472 THR A CG2 1 ATOM 3627 N N . ALA A 1 473 ? 29.427 48.711 10.635 1.00 27.95 ? 473 ALA A N 1 ATOM 3628 C CA . ALA A 1 473 ? 29.508 49.824 11.567 1.00 29.21 ? 473 ALA A CA 1 ATOM 3629 C C . ALA A 1 473 ? 30.406 49.454 12.746 1.00 30.31 ? 473 ALA A C 1 ATOM 3630 O O . ALA A 1 473 ? 30.065 49.723 13.903 1.00 30.85 ? 473 ALA A O 1 ATOM 3631 C CB . ALA A 1 473 ? 28.112 50.203 12.057 1.00 29.42 ? 473 ALA A CB 1 ATOM 3632 N N . CYS A 1 474 ? 31.546 48.822 12.457 1.00 31.19 ? 474 CYS A N 1 ATOM 3633 C CA . CYS A 1 474 ? 32.619 48.701 13.430 1.00 31.87 ? 474 CYS A CA 1 ATOM 3634 C C . CYS A 1 474 ? 32.931 50.155 13.686 1.00 32.77 ? 474 CYS A C 1 ATOM 3635 O O . CYS A 1 474 ? 32.568 51.008 12.875 1.00 34.10 ? 474 CYS A O 1 ATOM 3636 C CB . CYS A 1 474 ? 33.844 48.026 12.820 1.00 31.34 ? 474 CYS A CB 1 ATOM 3637 S SG . CYS A 1 474 ? 34.599 48.998 11.485 1.00 30.87 ? 474 CYS A SG 1 ATOM 3638 N N . ASP A 1 475 ? 33.581 50.490 14.772 1.00 33.43 ? 475 ASP A N 1 ATOM 3639 C CA . ASP A 1 475 ? 33.883 51.910 14.917 1.00 34.19 ? 475 ASP A CA 1 ATOM 3640 C C . ASP A 1 475 ? 35.375 52.154 14.854 1.00 33.52 ? 475 ASP A C 1 ATOM 3641 O O . ASP A 1 475 ? 35.953 52.923 15.628 1.00 33.95 ? 475 ASP A O 1 ATOM 3642 C CB . ASP A 1 475 ? 33.221 52.479 16.155 1.00 34.67 ? 475 ASP A CB 1 ATOM 3643 C CG . ASP A 1 475 ? 32.484 53.749 15.845 1.00 37.02 ? 475 ASP A CG 1 ATOM 3644 O OD1 . ASP A 1 475 ? 31.244 53.778 16.036 1.00 40.97 ? 475 ASP A OD1 1 ATOM 3645 O OD2 . ASP A 1 475 ? 33.061 54.741 15.340 1.00 39.78 ? 475 ASP A OD2 1 ATOM 3646 N N . LEU A 1 476 ? 35.975 51.513 13.862 1.00 32.81 ? 476 LEU A N 1 ATOM 3647 C CA . LEU A 1 476 ? 37.417 51.430 13.741 1.00 32.25 ? 476 LEU A CA 1 ATOM 3648 C C . LEU A 1 476 ? 37.923 52.385 12.680 1.00 31.63 ? 476 LEU A C 1 ATOM 3649 O O . LEU A 1 476 ? 37.269 52.607 11.667 1.00 31.53 ? 476 LEU A O 1 ATOM 3650 C CB . LEU A 1 476 ? 37.807 50.000 13.369 1.00 32.13 ? 476 LEU A CB 1 ATOM 3651 C CG . LEU A 1 476 ? 37.955 48.944 14.472 1.00 32.89 ? 476 LEU A CG 1 ATOM 3652 C CD1 . LEU A 1 476 ? 37.261 49.283 15.779 1.00 33.86 ? 476 LEU A CD1 1 ATOM 3653 C CD2 . LEU A 1 476 ? 37.498 47.598 13.958 1.00 32.88 ? 476 LEU A CD2 1 ATOM 3654 N N . ALA A 1 477 ? 39.104 52.937 12.927 1.00 31.17 ? 477 ALA A N 1 ATOM 3655 C CA . ALA A 1 477 ? 39.817 53.731 11.941 1.00 30.93 ? 477 ALA A CA 1 ATOM 3656 C C . ALA A 1 477 ? 40.300 52.814 10.818 1.00 30.82 ? 477 ALA A C 1 ATOM 3657 O O . ALA A 1 477 ? 40.417 51.602 11.023 1.00 30.45 ? 477 ALA A O 1 ATOM 3658 C CB . ALA A 1 477 ? 40.994 54.436 12.598 1.00 30.83 ? 477 ALA A CB 1 ATOM 3659 N N . PRO A 1 478 ? 40.571 53.373 9.634 1.00 31.03 ? 478 PRO A N 1 ATOM 3660 C CA . PRO A 1 478 ? 41.102 52.584 8.515 1.00 30.97 ? 478 PRO A CA 1 ATOM 3661 C C . PRO A 1 478 ? 42.376 51.826 8.883 1.00 30.94 ? 478 PRO A C 1 ATOM 3662 O O . PRO A 1 478 ? 43.146 52.308 9.726 1.00 30.68 ? 478 PRO A O 1 ATOM 3663 C CB . PRO A 1 478 ? 41.416 53.647 7.453 1.00 31.18 ? 478 PRO A CB 1 ATOM 3664 C CG . PRO A 1 478 ? 40.472 54.764 7.762 1.00 30.96 ? 478 PRO A CG 1 ATOM 3665 C CD . PRO A 1 478 ? 40.367 54.786 9.257 1.00 31.17 ? 478 PRO A CD 1 ATOM 3666 N N . PRO A 1 479 ? 42.611 50.670 8.257 1.00 30.84 ? 479 PRO A N 1 ATOM 3667 C CA . PRO A 1 479 ? 43.816 49.896 8.533 1.00 30.99 ? 479 PRO A CA 1 ATOM 3668 C C . PRO A 1 479 ? 45.083 50.753 8.476 1.00 31.45 ? 479 PRO A C 1 ATOM 3669 O O . PRO A 1 479 ? 45.182 51.664 7.644 1.00 31.31 ? 479 PRO A O 1 ATOM 3670 C CB . PRO A 1 479 ? 43.825 48.847 7.423 1.00 30.95 ? 479 PRO A CB 1 ATOM 3671 C CG . PRO A 1 479 ? 42.386 48.675 7.047 1.00 30.92 ? 479 PRO A CG 1 ATOM 3672 C CD . PRO A 1 479 ? 41.756 50.019 7.248 1.00 30.84 ? 479 PRO A CD 1 ATOM 3673 N N . ALA A 1 480 ? 46.028 50.454 9.360 1.00 31.85 ? 480 ALA A N 1 ATOM 3674 C CA . ALA A 1 480 ? 47.312 51.152 9.409 1.00 32.40 ? 480 ALA A CA 1 ATOM 3675 C C . ALA A 1 480 ? 48.116 50.895 8.144 1.00 32.83 ? 480 ALA A C 1 ATOM 3676 O O . ALA A 1 480 ? 48.109 49.789 7.592 1.00 33.27 ? 480 ALA A O 1 ATOM 3677 C CB . ALA A 1 480 ? 48.108 50.713 10.635 1.00 32.31 ? 480 ALA A CB 1 HETATM 3678 C C1 . NAG B 2 . ? 12.583 15.271 3.801 1.00 27.45 ? 801 NAG A C1 1 HETATM 3679 C C2 . NAG B 2 . ? 11.268 15.656 4.508 1.00 28.45 ? 801 NAG A C2 1 HETATM 3680 C C3 . NAG B 2 . ? 10.691 14.464 5.287 1.00 30.17 ? 801 NAG A C3 1 HETATM 3681 C C4 . NAG B 2 . ? 10.600 13.232 4.389 1.00 31.03 ? 801 NAG A C4 1 HETATM 3682 C C5 . NAG B 2 . ? 11.943 12.988 3.709 1.00 31.89 ? 801 NAG A C5 1 HETATM 3683 C C6 . NAG B 2 . ? 11.912 11.768 2.776 1.00 33.20 ? 801 NAG A C6 1 HETATM 3684 C C7 . NAG B 2 . ? 11.028 18.051 4.942 1.00 25.69 ? 801 NAG A C7 1 HETATM 3685 C C8 . NAG B 2 . ? 11.494 19.201 5.791 1.00 24.88 ? 801 NAG A C8 1 HETATM 3686 N N2 . NAG B 2 . ? 11.354 16.829 5.376 1.00 26.43 ? 801 NAG A N2 1 HETATM 3687 O O3 . NAG B 2 . ? 9.413 14.812 5.788 1.00 29.01 ? 801 NAG A O3 1 HETATM 3688 O O4 . NAG B 2 . ? 10.261 12.092 5.154 1.00 33.54 ? 801 NAG A O4 1 HETATM 3689 O O5 . NAG B 2 . ? 12.308 14.146 2.979 1.00 30.01 ? 801 NAG A O5 1 HETATM 3690 O O6 . NAG B 2 . ? 10.786 11.774 1.914 1.00 35.15 ? 801 NAG A O6 1 HETATM 3691 O O7 . NAG B 2 . ? 10.385 18.263 3.915 1.00 23.41 ? 801 NAG A O7 1 HETATM 3692 C C1 . NAG C 2 . ? 53.761 20.097 -14.320 1.00 26.69 ? 803 NAG A C1 1 HETATM 3693 C C2 . NAG C 2 . ? 54.498 18.929 -15.001 1.00 30.30 ? 803 NAG A C2 1 HETATM 3694 C C3 . NAG C 2 . ? 54.830 19.219 -16.469 1.00 30.42 ? 803 NAG A C3 1 HETATM 3695 C C4 . NAG C 2 . ? 53.561 19.577 -17.210 1.00 30.74 ? 803 NAG A C4 1 HETATM 3696 C C5 . NAG C 2 . ? 52.795 20.674 -16.469 1.00 30.29 ? 803 NAG A C5 1 HETATM 3697 C C6 . NAG C 2 . ? 51.440 20.828 -17.136 1.00 30.08 ? 803 NAG A C6 1 HETATM 3698 C C7 . NAG C 2 . ? 55.960 17.354 -13.864 1.00 33.17 ? 803 NAG A C7 1 HETATM 3699 C C8 . NAG C 2 . ? 57.269 17.151 -13.170 1.00 34.06 ? 803 NAG A C8 1 HETATM 3700 N N2 . NAG C 2 . ? 55.712 18.591 -14.282 1.00 31.25 ? 803 NAG A N2 1 HETATM 3701 O O3 . NAG C 2 . ? 55.356 18.067 -17.083 1.00 31.45 ? 803 NAG A O3 1 HETATM 3702 O O4 . NAG C 2 . ? 53.877 19.999 -18.525 1.00 31.69 ? 803 NAG A O4 1 HETATM 3703 O O5 . NAG C 2 . ? 52.602 20.373 -15.087 1.00 27.67 ? 803 NAG A O5 1 HETATM 3704 O O6 . NAG C 2 . ? 50.904 22.039 -16.676 1.00 34.54 ? 803 NAG A O6 1 HETATM 3705 O O7 . NAG C 2 . ? 55.185 16.408 -14.010 1.00 36.00 ? 803 NAG A O7 1 HETATM 3706 ZN ZN . ZN D 3 . ? 39.232 14.279 12.247 1.00 14.88 ? 901 ZN A ZN 1 HETATM 3707 ZN ZN . ZN E 3 . ? 38.917 18.215 12.366 1.00 14.95 ? 902 ZN A ZN 1 HETATM 3708 MG MG . MG F 4 . ? 40.157 19.609 8.021 1.00 10.77 ? 903 MG A MG 1 HETATM 3709 CA CA . CA G 5 . ? 51.325 15.515 -6.471 1.00 18.82 ? 904 CA A CA 1 HETATM 3710 O O . HOH H 6 . ? 52.063 19.619 6.079 1.00 10.75 ? 906 HOH A O 1 HETATM 3711 O O . HOH H 6 . ? 50.742 9.891 2.494 1.00 23.70 ? 907 HOH A O 1 HETATM 3712 O O . HOH H 6 . ? 35.293 29.538 -6.936 1.00 13.49 ? 908 HOH A O 1 HETATM 3713 O O . HOH H 6 . ? 21.857 16.404 12.148 1.00 12.85 ? 909 HOH A O 1 HETATM 3714 O O . HOH H 6 . ? 41.546 18.016 7.953 1.00 12.73 ? 910 HOH A O 1 HETATM 3715 O O . HOH H 6 . ? 32.939 19.666 24.370 1.00 17.27 ? 911 HOH A O 1 HETATM 3716 O O . HOH H 6 . ? 58.988 29.099 8.386 1.00 17.36 ? 912 HOH A O 1 HETATM 3717 O O . HOH H 6 . ? 58.068 7.293 33.808 1.00 17.59 ? 913 HOH A O 1 HETATM 3718 O O . HOH H 6 . ? 42.875 21.025 23.229 1.00 6.91 ? 914 HOH A O 1 HETATM 3719 O O . HOH H 6 . ? 63.320 10.126 29.462 1.00 17.95 ? 915 HOH A O 1 HETATM 3720 O O . HOH H 6 . ? 30.124 28.630 4.025 1.00 15.09 ? 916 HOH A O 1 HETATM 3721 O O . HOH H 6 . ? 49.110 39.099 11.632 1.00 15.20 ? 917 HOH A O 1 HETATM 3722 O O . HOH H 6 . ? 52.879 2.144 25.340 1.00 13.48 ? 918 HOH A O 1 HETATM 3723 O O . HOH H 6 . ? 45.683 17.562 21.070 1.00 14.97 ? 919 HOH A O 1 HETATM 3724 O O . HOH H 6 . ? 32.763 22.404 24.319 1.00 14.29 ? 920 HOH A O 1 HETATM 3725 O O . HOH H 6 . ? 22.522 27.101 14.516 1.00 15.74 ? 921 HOH A O 1 HETATM 3726 O O . HOH H 6 . ? 50.154 16.834 4.387 1.00 20.63 ? 922 HOH A O 1 HETATM 3727 O O . HOH H 6 . ? 53.248 20.108 3.608 1.00 14.61 ? 923 HOH A O 1 HETATM 3728 O O . HOH H 6 . ? 60.419 34.458 -1.552 1.00 11.55 ? 924 HOH A O 1 HETATM 3729 O O . HOH H 6 . ? 50.469 43.140 5.600 1.00 21.13 ? 925 HOH A O 1 HETATM 3730 O O . HOH H 6 . ? 52.074 9.353 38.749 1.00 20.39 ? 926 HOH A O 1 HETATM 3731 O O . HOH H 6 . ? 38.523 18.484 7.717 1.00 12.47 ? 927 HOH A O 1 HETATM 3732 O O . HOH H 6 . ? 44.995 24.129 20.781 1.00 12.75 ? 928 HOH A O 1 HETATM 3733 O O . HOH H 6 . ? 33.751 17.967 3.171 1.00 18.86 ? 929 HOH A O 1 HETATM 3734 O O . HOH H 6 . ? 38.619 26.867 17.695 1.00 11.85 ? 930 HOH A O 1 HETATM 3735 O O . HOH H 6 . ? 52.634 34.399 23.440 1.00 15.39 ? 931 HOH A O 1 HETATM 3736 O O . HOH H 6 . ? 56.807 23.307 26.469 1.00 17.03 ? 932 HOH A O 1 HETATM 3737 O O . HOH H 6 . ? 23.477 21.904 11.029 1.00 14.44 ? 933 HOH A O 1 HETATM 3738 O O . HOH H 6 . ? 37.810 19.883 20.930 1.00 12.09 ? 934 HOH A O 1 HETATM 3739 O O . HOH H 6 . ? 58.663 2.462 29.755 1.00 16.48 ? 935 HOH A O 1 HETATM 3740 O O . HOH H 6 . ? 36.140 1.102 14.864 1.00 18.69 ? 936 HOH A O 1 HETATM 3741 O O . HOH H 6 . ? 40.122 19.846 5.871 1.00 10.94 ? 937 HOH A O 1 HETATM 3742 O O . HOH H 6 . ? 35.264 15.936 4.499 1.00 17.84 ? 938 HOH A O 1 HETATM 3743 O O . HOH H 6 . ? 31.701 24.256 17.419 1.00 13.84 ? 939 HOH A O 1 HETATM 3744 O O . HOH H 6 . ? 32.774 8.015 -9.222 1.00 20.48 ? 940 HOH A O 1 HETATM 3745 O O . HOH H 6 . ? 61.508 10.102 35.315 1.00 22.16 ? 941 HOH A O 1 HETATM 3746 O O . HOH H 6 . ? 37.270 21.955 10.592 1.00 13.68 ? 942 HOH A O 1 HETATM 3747 O O . HOH H 6 . ? 32.464 28.759 -4.051 1.00 14.97 ? 943 HOH A O 1 HETATM 3748 O O . HOH H 6 . ? 50.651 0.226 19.129 1.00 18.25 ? 944 HOH A O 1 HETATM 3749 O O . HOH H 6 . ? 56.909 35.645 -1.776 1.00 13.63 ? 945 HOH A O 1 HETATM 3750 O O . HOH H 6 . ? 52.363 16.862 0.457 1.00 21.16 ? 946 HOH A O 1 HETATM 3751 O O . HOH H 6 . ? 42.334 -0.886 27.920 1.00 15.35 ? 947 HOH A O 1 HETATM 3752 O O . HOH H 6 . ? 29.507 30.687 2.819 1.00 12.37 ? 948 HOH A O 1 HETATM 3753 O O . HOH H 6 . ? 51.564 15.576 -1.895 1.00 14.66 ? 949 HOH A O 1 HETATM 3754 O O . HOH H 6 . ? 42.932 36.044 27.185 1.00 10.44 ? 950 HOH A O 1 HETATM 3755 O O . HOH H 6 . ? 23.471 21.914 -0.734 1.00 18.88 ? 951 HOH A O 1 HETATM 3756 O O . HOH H 6 . ? 18.876 14.016 1.353 1.00 24.69 ? 952 HOH A O 1 HETATM 3757 O O . HOH H 6 . ? 56.377 8.508 22.794 1.00 14.31 ? 953 HOH A O 1 HETATM 3758 O O . HOH H 6 . ? 58.484 21.243 8.646 1.00 21.80 ? 954 HOH A O 1 HETATM 3759 O O . HOH H 6 . ? 51.736 34.375 11.306 1.00 15.16 ? 955 HOH A O 1 HETATM 3760 O O . HOH H 6 . ? 52.326 7.985 29.009 1.00 11.92 ? 956 HOH A O 1 HETATM 3761 O O . HOH H 6 . ? 52.650 3.141 22.641 1.00 15.15 ? 957 HOH A O 1 HETATM 3762 O O . HOH H 6 . ? 44.428 45.340 18.640 1.00 19.37 ? 958 HOH A O 1 HETATM 3763 O O . HOH H 6 . ? 22.666 20.430 1.663 1.00 15.07 ? 959 HOH A O 1 HETATM 3764 O O . HOH H 6 . ? 40.467 15.622 25.950 1.00 14.61 ? 960 HOH A O 1 HETATM 3765 O O . HOH H 6 . ? 45.364 48.450 11.236 1.00 21.20 ? 961 HOH A O 1 HETATM 3766 O O . HOH H 6 . ? 54.038 14.502 -3.226 1.00 19.31 ? 962 HOH A O 1 HETATM 3767 O O . HOH H 6 . ? 56.504 20.224 -10.249 1.00 20.68 ? 963 HOH A O 1 HETATM 3768 O O . HOH H 6 . ? 29.488 24.053 15.561 1.00 13.54 ? 964 HOH A O 1 HETATM 3769 O O . HOH H 6 . ? 40.191 15.604 8.799 1.00 14.21 ? 965 HOH A O 1 HETATM 3770 O O . HOH H 6 . ? 58.029 33.997 32.999 1.00 18.33 ? 966 HOH A O 1 HETATM 3771 O O . HOH H 6 . ? 25.042 19.726 -0.833 1.00 19.14 ? 967 HOH A O 1 HETATM 3772 O O . HOH H 6 . ? 54.970 38.561 27.846 1.00 23.02 ? 968 HOH A O 1 HETATM 3773 O O . HOH H 6 . ? 45.788 3.969 19.328 1.00 22.21 ? 969 HOH A O 1 HETATM 3774 O O . HOH H 6 . ? 26.830 23.425 9.721 1.00 14.37 ? 970 HOH A O 1 HETATM 3775 O O . HOH H 6 . ? 48.649 18.989 7.318 1.00 15.12 ? 971 HOH A O 1 HETATM 3776 O O . HOH H 6 . ? 44.299 17.595 -13.735 1.00 27.83 ? 972 HOH A O 1 HETATM 3777 O O . HOH H 6 . ? 61.110 15.069 20.373 1.00 20.35 ? 973 HOH A O 1 HETATM 3778 O O . HOH H 6 . ? 54.148 7.851 15.790 1.00 15.49 ? 974 HOH A O 1 HETATM 3779 O O . HOH H 6 . ? 50.394 36.075 9.591 1.00 16.52 ? 975 HOH A O 1 HETATM 3780 O O . HOH H 6 . ? 54.785 34.158 15.261 1.00 22.66 ? 976 HOH A O 1 HETATM 3781 O O . HOH H 6 . ? 59.257 21.777 -8.372 1.00 21.09 ? 977 HOH A O 1 HETATM 3782 O O . HOH H 6 . ? 17.397 21.346 -0.685 1.00 18.24 ? 978 HOH A O 1 HETATM 3783 O O . HOH H 6 . ? 55.897 6.977 20.435 1.00 14.83 ? 979 HOH A O 1 HETATM 3784 O O . HOH H 6 . ? 59.660 24.613 19.477 1.00 16.65 ? 980 HOH A O 1 HETATM 3785 O O . HOH H 6 . ? 24.167 10.504 1.458 1.00 23.74 ? 981 HOH A O 1 HETATM 3786 O O . HOH H 6 . ? 45.598 42.162 -0.661 1.00 22.30 ? 982 HOH A O 1 HETATM 3787 O O . HOH H 6 . ? 16.031 15.234 1.726 1.00 24.38 ? 983 HOH A O 1 HETATM 3788 O O . HOH H 6 . ? 57.252 33.456 30.119 1.00 19.42 ? 984 HOH A O 1 HETATM 3789 O O . HOH H 6 . ? 60.758 23.047 10.847 1.00 22.14 ? 985 HOH A O 1 HETATM 3790 O O . HOH H 6 . ? 44.961 6.278 -18.302 1.00 38.53 ? 986 HOH A O 1 HETATM 3791 O O . HOH H 6 . ? 36.646 4.035 13.986 1.00 20.91 ? 987 HOH A O 1 HETATM 3792 O O . HOH H 6 . ? 50.480 9.664 27.600 1.00 12.60 ? 988 HOH A O 1 HETATM 3793 O O . HOH H 6 . ? 42.416 15.476 -14.471 1.00 28.24 ? 989 HOH A O 1 HETATM 3794 O O . HOH H 6 . ? 60.668 26.902 7.545 1.00 22.73 ? 990 HOH A O 1 HETATM 3795 O O . HOH H 6 . ? 10.601 19.481 1.333 1.00 24.82 ? 991 HOH A O 1 HETATM 3796 O O . HOH H 6 . ? 24.329 15.741 12.830 1.00 19.70 ? 992 HOH A O 1 HETATM 3797 O O . HOH H 6 . ? 26.617 39.118 15.515 1.00 22.52 ? 993 HOH A O 1 HETATM 3798 O O . HOH H 6 . ? 57.831 0.836 14.802 1.00 28.53 ? 994 HOH A O 1 HETATM 3799 O O . HOH H 6 . ? 51.927 17.427 -7.868 1.00 23.40 ? 995 HOH A O 1 HETATM 3800 O O . HOH H 6 . ? 47.449 24.943 22.416 1.00 16.24 ? 996 HOH A O 1 HETATM 3801 O O . HOH H 6 . ? 42.474 11.277 0.078 1.00 21.82 ? 997 HOH A O 1 HETATM 3802 O O . HOH H 6 . ? 41.362 13.407 -13.445 1.00 25.67 ? 998 HOH A O 1 HETATM 3803 O O . HOH H 6 . ? 60.180 31.063 7.015 1.00 18.17 ? 999 HOH A O 1 HETATM 3804 O O . HOH H 6 . ? 51.927 19.498 1.437 1.00 29.32 ? 1000 HOH A O 1 HETATM 3805 O O . HOH H 6 . ? 48.212 -1.987 23.266 1.00 20.91 ? 1001 HOH A O 1 HETATM 3806 O O . HOH H 6 . ? 42.188 12.883 -10.707 1.00 20.04 ? 1002 HOH A O 1 HETATM 3807 O O . HOH H 6 . ? 33.311 11.488 -5.513 1.00 15.94 ? 1003 HOH A O 1 HETATM 3808 O O . HOH H 6 . ? 60.302 11.416 26.132 1.00 21.76 ? 1004 HOH A O 1 HETATM 3809 O O . HOH H 6 . ? 29.150 13.936 27.483 1.00 25.82 ? 1005 HOH A O 1 HETATM 3810 O O . HOH H 6 . ? 52.752 -0.798 20.653 1.00 20.58 ? 1006 HOH A O 1 HETATM 3811 O O . HOH H 6 . ? 38.950 45.348 6.156 1.00 27.38 ? 1007 HOH A O 1 HETATM 3812 O O . HOH H 6 . ? 74.738 25.562 39.637 1.00 25.28 ? 1008 HOH A O 1 HETATM 3813 O O . HOH H 6 . ? 72.073 31.270 34.129 1.00 23.02 ? 1009 HOH A O 1 HETATM 3814 O O . HOH H 6 . ? 45.636 9.489 25.816 1.00 13.77 ? 1010 HOH A O 1 HETATM 3815 O O . HOH H 6 . ? 50.518 20.936 8.000 1.00 15.99 ? 1011 HOH A O 1 HETATM 3816 O O . HOH H 6 . ? 46.204 45.021 24.490 1.00 34.57 ? 1012 HOH A O 1 HETATM 3817 O O . HOH H 6 . ? 44.844 18.512 25.153 1.00 21.19 ? 1013 HOH A O 1 HETATM 3818 O O . HOH H 6 . ? 53.306 35.552 13.100 1.00 22.79 ? 1014 HOH A O 1 HETATM 3819 O O . HOH H 6 . ? 56.990 7.136 6.659 1.00 31.74 ? 1015 HOH A O 1 HETATM 3820 O O . HOH H 6 . ? 54.533 42.131 11.399 1.00 21.63 ? 1016 HOH A O 1 HETATM 3821 O O . HOH H 6 . ? 26.969 9.998 4.524 1.00 33.50 ? 1017 HOH A O 1 HETATM 3822 O O . HOH H 6 . ? 52.342 3.121 -16.615 1.00 29.04 ? 1018 HOH A O 1 HETATM 3823 O O . HOH H 6 . ? 67.554 36.914 40.243 1.00 23.83 ? 1019 HOH A O 1 HETATM 3824 O O . HOH H 6 . ? 33.434 8.861 -6.128 1.00 24.25 ? 1020 HOH A O 1 HETATM 3825 O O . HOH H 6 . ? 32.271 10.546 0.365 1.00 20.61 ? 1021 HOH A O 1 HETATM 3826 O O . HOH H 6 . ? 21.059 23.793 -2.130 1.00 36.84 ? 1022 HOH A O 1 HETATM 3827 O O . HOH H 6 . ? 18.865 22.909 -2.119 1.00 25.53 ? 1023 HOH A O 1 HETATM 3828 O O . HOH H 6 . ? 15.047 26.714 8.796 1.00 26.10 ? 1024 HOH A O 1 HETATM 3829 O O . HOH H 6 . ? 57.087 35.155 11.343 1.00 20.22 ? 1025 HOH A O 1 HETATM 3830 O O . HOH H 6 . ? 43.090 40.310 25.463 1.00 26.76 ? 1026 HOH A O 1 HETATM 3831 O O . HOH H 6 . ? 18.320 28.877 10.165 1.00 21.31 ? 1027 HOH A O 1 HETATM 3832 O O . HOH H 6 . ? 29.763 30.766 0.022 1.00 19.88 ? 1028 HOH A O 1 HETATM 3833 O O . HOH H 6 . ? 72.769 25.480 29.894 1.00 29.09 ? 1029 HOH A O 1 HETATM 3834 O O . HOH H 6 . ? 62.159 13.187 18.600 1.00 26.29 ? 1030 HOH A O 1 HETATM 3835 O O . HOH H 6 . ? 56.939 7.482 16.148 1.00 16.40 ? 1031 HOH A O 1 HETATM 3836 O O . HOH H 6 . ? 36.256 10.215 -2.013 1.00 20.44 ? 1032 HOH A O 1 HETATM 3837 O O . HOH H 6 . ? 25.730 12.889 -11.190 1.00 32.46 ? 1033 HOH A O 1 HETATM 3838 O O . HOH H 6 . ? 54.373 14.287 7.885 1.00 15.10 ? 1034 HOH A O 1 HETATM 3839 O O . HOH H 6 . ? 44.383 8.192 -13.145 1.00 32.70 ? 1035 HOH A O 1 HETATM 3840 O O . HOH H 6 . ? 14.285 26.509 6.371 1.00 19.16 ? 1036 HOH A O 1 HETATM 3841 O O . HOH H 6 . ? 36.580 6.416 15.347 1.00 21.83 ? 1037 HOH A O 1 HETATM 3842 O O . HOH H 6 . ? 37.819 8.005 -13.694 1.00 22.71 ? 1038 HOH A O 1 HETATM 3843 O O . HOH H 6 . ? 56.189 33.291 -13.917 1.00 24.49 ? 1039 HOH A O 1 HETATM 3844 O O . HOH H 6 . ? 67.127 15.470 33.319 1.00 16.95 ? 1040 HOH A O 1 HETATM 3845 O O . HOH H 6 . ? 61.019 15.090 -1.858 1.00 34.75 ? 1041 HOH A O 1 HETATM 3846 O O . HOH H 6 . ? 60.906 32.610 33.873 1.00 15.76 ? 1042 HOH A O 1 HETATM 3847 O O . HOH H 6 . ? 31.591 35.889 -5.472 1.00 22.54 ? 1043 HOH A O 1 HETATM 3848 O O . HOH H 6 . ? 18.490 25.415 -7.908 1.00 39.03 ? 1044 HOH A O 1 HETATM 3849 O O . HOH H 6 . ? 61.755 9.249 27.182 1.00 19.19 ? 1045 HOH A O 1 HETATM 3850 O O . HOH H 6 . ? 22.288 14.714 15.729 1.00 23.85 ? 1046 HOH A O 1 HETATM 3851 O O . HOH H 6 . ? 61.765 9.064 16.229 1.00 33.76 ? 1047 HOH A O 1 HETATM 3852 O O . HOH H 6 . ? 45.510 26.790 -16.802 1.00 22.85 ? 1048 HOH A O 1 HETATM 3853 O O . HOH H 6 . ? 37.564 45.523 2.081 1.00 30.56 ? 1049 HOH A O 1 HETATM 3854 O O . HOH H 6 . ? 30.838 11.918 -16.154 1.00 28.74 ? 1050 HOH A O 1 HETATM 3855 O O . HOH H 6 . ? 56.695 28.710 23.957 1.00 17.33 ? 1051 HOH A O 1 HETATM 3856 O O . HOH H 6 . ? 48.311 43.979 20.583 1.00 26.19 ? 1052 HOH A O 1 HETATM 3857 O O . HOH H 6 . ? 27.100 31.146 -0.571 1.00 17.22 ? 1053 HOH A O 1 HETATM 3858 O O . HOH H 6 . ? 68.213 14.200 35.326 1.00 22.27 ? 1054 HOH A O 1 HETATM 3859 O O . HOH H 6 . ? 20.300 15.038 13.849 1.00 27.97 ? 1055 HOH A O 1 HETATM 3860 O O . HOH H 6 . ? 50.543 21.880 -13.570 1.00 22.51 ? 1056 HOH A O 1 HETATM 3861 O O . HOH H 6 . ? 43.988 37.960 25.451 1.00 32.17 ? 1057 HOH A O 1 HETATM 3862 O O . HOH H 6 . ? 45.531 11.734 -2.786 1.00 15.25 ? 1058 HOH A O 1 HETATM 3863 O O . HOH H 6 . ? 57.446 18.731 9.666 1.00 20.67 ? 1059 HOH A O 1 HETATM 3864 O O . HOH H 6 . ? 51.302 39.328 10.117 1.00 18.23 ? 1060 HOH A O 1 HETATM 3865 O O . HOH H 6 . ? 57.332 33.979 14.121 1.00 30.26 ? 1061 HOH A O 1 HETATM 3866 O O . HOH H 6 . ? 33.612 9.576 -2.092 1.00 22.28 ? 1062 HOH A O 1 HETATM 3867 O O . HOH H 6 . ? 42.474 -3.593 27.690 1.00 22.88 ? 1063 HOH A O 1 HETATM 3868 O O . HOH H 6 . ? 60.062 26.271 17.480 1.00 26.83 ? 1064 HOH A O 1 HETATM 3869 O O . HOH H 6 . ? 74.262 21.994 40.472 1.00 28.87 ? 1065 HOH A O 1 HETATM 3870 O O . HOH H 6 . ? 59.814 7.742 36.349 1.00 34.09 ? 1066 HOH A O 1 HETATM 3871 O O . HOH H 6 . ? 29.949 35.941 11.814 1.00 24.53 ? 1067 HOH A O 1 HETATM 3872 O O . HOH H 6 . ? 26.324 27.297 -6.496 1.00 30.21 ? 1068 HOH A O 1 HETATM 3873 O O . HOH H 6 . ? 37.413 40.404 -4.935 1.00 25.05 ? 1069 HOH A O 1 HETATM 3874 O O . HOH H 6 . ? 28.900 29.639 26.254 1.00 26.50 ? 1070 HOH A O 1 HETATM 3875 O O . HOH H 6 . ? 48.967 44.879 3.463 1.00 28.83 ? 1071 HOH A O 1 HETATM 3876 O O . HOH H 6 . ? 58.007 36.902 -12.800 1.00 33.31 ? 1072 HOH A O 1 HETATM 3877 O O . HOH H 6 . ? 40.100 6.735 -13.770 1.00 27.21 ? 1073 HOH A O 1 HETATM 3878 O O . HOH H 6 . ? 62.080 12.213 15.956 1.00 23.30 ? 1074 HOH A O 1 HETATM 3879 O O . HOH H 6 . ? 46.188 52.038 16.558 1.00 30.99 ? 1075 HOH A O 1 HETATM 3880 O O . HOH H 6 . ? 56.737 41.571 5.120 1.00 31.53 ? 1076 HOH A O 1 HETATM 3881 O O . HOH H 6 . ? 62.557 9.036 18.899 1.00 20.66 ? 1077 HOH A O 1 HETATM 3882 O O . HOH H 6 . ? 62.303 6.526 20.211 1.00 28.08 ? 1078 HOH A O 1 HETATM 3883 O O . HOH H 6 . ? 53.851 39.469 10.919 1.00 18.03 ? 1079 HOH A O 1 HETATM 3884 O O . HOH H 6 . ? 72.008 16.615 33.845 1.00 25.44 ? 1080 HOH A O 1 HETATM 3885 O O . HOH H 6 . ? 49.368 42.150 17.446 1.00 23.54 ? 1081 HOH A O 1 HETATM 3886 O O . HOH H 6 . ? 64.267 27.359 29.316 1.00 20.80 ? 1082 HOH A O 1 HETATM 3887 O O . HOH H 6 . ? 21.663 26.116 -0.710 1.00 23.87 ? 1083 HOH A O 1 HETATM 3888 O O . HOH H 6 . ? 44.386 13.827 -17.821 1.00 31.69 ? 1084 HOH A O 1 HETATM 3889 O O . HOH H 6 . ? 21.515 18.814 -7.981 1.00 24.58 ? 1085 HOH A O 1 HETATM 3890 O O . HOH H 6 . ? 27.496 34.957 11.753 1.00 24.55 ? 1086 HOH A O 1 HETATM 3891 O O . HOH H 6 . ? 66.918 33.893 30.786 1.00 22.63 ? 1087 HOH A O 1 HETATM 3892 O O . HOH H 6 . ? 28.294 25.577 -11.557 1.00 34.24 ? 1088 HOH A O 1 HETATM 3893 O O . HOH H 6 . ? 23.412 39.486 12.406 1.00 26.61 ? 1089 HOH A O 1 HETATM 3894 O O . HOH H 6 . ? 59.548 18.480 11.487 1.00 25.01 ? 1090 HOH A O 1 HETATM 3895 O O . HOH H 6 . ? 23.467 23.209 -3.201 1.00 24.87 ? 1091 HOH A O 1 HETATM 3896 O O . HOH H 6 . ? 27.832 10.061 0.036 1.00 26.54 ? 1092 HOH A O 1 HETATM 3897 O O . HOH H 6 . ? 63.618 8.400 25.307 1.00 26.55 ? 1093 HOH A O 1 HETATM 3898 O O . HOH H 6 . ? 52.820 -4.220 18.660 1.00 28.77 ? 1094 HOH A O 1 HETATM 3899 O O . HOH H 6 . ? 49.730 45.845 28.071 1.00 29.48 ? 1095 HOH A O 1 HETATM 3900 O O . HOH H 6 . ? 26.860 45.225 8.878 1.00 25.41 ? 1096 HOH A O 1 HETATM 3901 O O . HOH H 6 . ? 17.989 8.753 -3.580 1.00 27.09 ? 1097 HOH A O 1 HETATM 3902 O O . HOH H 6 . ? 19.972 12.929 9.827 1.00 24.97 ? 1098 HOH A O 1 HETATM 3903 O O . HOH H 6 . ? 51.249 46.137 21.061 1.00 28.51 ? 1099 HOH A O 1 HETATM 3904 O O . HOH H 6 . ? 39.665 5.102 -18.393 1.00 34.50 ? 1100 HOH A O 1 HETATM 3905 O O . HOH H 6 . ? 26.220 29.905 -2.582 1.00 33.12 ? 1101 HOH A O 1 HETATM 3906 O O . HOH H 6 . ? 67.370 25.343 24.785 1.00 37.55 ? 1102 HOH A O 1 HETATM 3907 O O . HOH H 6 . ? 68.357 18.070 21.074 1.00 38.78 ? 1103 HOH A O 1 HETATM 3908 O O . HOH H 6 . ? 30.703 41.802 2.740 1.00 34.64 ? 1104 HOH A O 1 HETATM 3909 O O . HOH H 6 . ? 49.543 5.036 5.833 1.00 50.32 ? 1105 HOH A O 1 HETATM 3910 O O . HOH H 6 . ? 38.168 47.778 19.479 1.00 23.02 ? 1106 HOH A O 1 HETATM 3911 O O . HOH H 6 . ? 31.283 7.674 -4.656 1.00 29.91 ? 1107 HOH A O 1 HETATM 3912 O O . HOH H 6 . ? 39.692 24.083 29.214 1.00 17.07 ? 1108 HOH A O 1 HETATM 3913 O O . HOH H 6 . ? 12.097 16.630 13.966 1.00 36.22 ? 1109 HOH A O 1 HETATM 3914 O O . HOH H 6 . ? 35.376 32.371 6.926 1.00 24.36 ? 1110 HOH A O 1 HETATM 3915 O O . HOH H 6 . ? 47.592 45.484 -1.037 1.00 28.04 ? 1111 HOH A O 1 HETATM 3916 O O . HOH H 6 . ? 63.275 29.814 28.963 1.00 27.30 ? 1112 HOH A O 1 HETATM 3917 O O . HOH H 6 . ? 31.943 21.063 -17.949 1.00 29.44 ? 1113 HOH A O 1 HETATM 3918 O O . HOH H 6 . ? 59.398 8.499 6.622 1.00 31.53 ? 1114 HOH A O 1 HETATM 3919 O O . HOH H 6 . ? 47.883 6.997 5.793 1.00 29.10 ? 1115 HOH A O 1 HETATM 3920 O O . HOH H 6 . ? 42.613 38.043 -7.905 1.00 36.03 ? 1116 HOH A O 1 HETATM 3921 O O . HOH H 6 . ? 64.027 8.780 35.048 1.00 29.62 ? 1117 HOH A O 1 HETATM 3922 O O . HOH H 6 . ? 74.524 31.268 35.661 1.00 43.92 ? 1118 HOH A O 1 HETATM 3923 O O . HOH H 6 . ? 25.684 11.183 14.052 1.00 34.69 ? 1119 HOH A O 1 HETATM 3924 O O . HOH H 6 . ? 54.756 6.651 36.925 1.00 30.82 ? 1120 HOH A O 1 HETATM 3925 O O . HOH H 6 . ? 64.352 4.545 26.526 1.00 29.71 ? 1121 HOH A O 1 HETATM 3926 O O . HOH H 6 . ? 28.640 23.362 -12.787 1.00 37.18 ? 1122 HOH A O 1 HETATM 3927 O O . HOH H 6 . ? 50.436 -1.234 16.759 1.00 24.65 ? 1123 HOH A O 1 HETATM 3928 O O . HOH H 6 . ? 26.572 37.255 10.322 1.00 43.08 ? 1124 HOH A O 1 HETATM 3929 O O . HOH H 6 . ? 47.775 10.305 -3.973 1.00 36.32 ? 1125 HOH A O 1 HETATM 3930 O O . HOH H 6 . ? 47.902 45.887 14.956 1.00 31.92 ? 1126 HOH A O 1 HETATM 3931 O O . HOH H 6 . ? 67.243 27.881 26.279 1.00 48.56 ? 1127 HOH A O 1 HETATM 3932 O O . HOH H 6 . ? 47.530 48.620 5.284 1.00 28.79 ? 1128 HOH A O 1 HETATM 3933 O O . HOH H 6 . ? 25.970 16.860 -7.649 1.00 33.19 ? 1129 HOH A O 1 HETATM 3934 O O . HOH H 6 . ? 28.405 34.153 -3.086 1.00 31.33 ? 1130 HOH A O 1 HETATM 3935 O O . HOH H 6 . ? 61.508 -1.980 25.842 1.00 29.49 ? 1131 HOH A O 1 HETATM 3936 O O . HOH H 6 . ? 32.447 35.250 26.423 1.00 36.37 ? 1132 HOH A O 1 HETATM 3937 O O . HOH H 6 . ? 59.915 16.454 3.482 1.00 33.55 ? 1133 HOH A O 1 HETATM 3938 O O . HOH H 6 . ? 42.990 1.774 11.099 1.00 35.17 ? 1134 HOH A O 1 HETATM 3939 O O . HOH H 6 . ? 58.904 17.018 8.411 1.00 32.90 ? 1135 HOH A O 1 HETATM 3940 O O . HOH H 6 . ? 14.540 26.991 11.626 1.00 34.84 ? 1136 HOH A O 1 HETATM 3941 O O . HOH H 6 . ? 42.580 13.427 -20.334 1.00 41.10 ? 1137 HOH A O 1 HETATM 3942 O O . HOH H 6 . ? 42.721 14.667 24.880 1.00 28.37 ? 1138 HOH A O 1 HETATM 3943 O O . HOH H 6 . ? 46.452 43.958 18.618 1.00 26.14 ? 1139 HOH A O 1 HETATM 3944 O O . HOH H 6 . ? 18.845 30.914 8.858 1.00 29.13 ? 1140 HOH A O 1 HETATM 3945 O O . HOH H 6 . ? 30.784 43.511 4.514 1.00 31.34 ? 1141 HOH A O 1 HETATM 3946 O O . HOH H 6 . ? 59.714 30.643 16.896 1.00 35.92 ? 1142 HOH A O 1 HETATM 3947 O O . HOH H 6 . ? 63.024 -3.148 18.345 1.00 35.33 ? 1143 HOH A O 1 HETATM 3948 O O . HOH H 6 . ? 17.001 13.458 -0.311 1.00 47.39 ? 1144 HOH A O 1 HETATM 3949 O O . HOH H 6 . ? 46.266 -11.338 21.300 1.00 36.26 ? 1145 HOH A O 1 HETATM 3950 O O . HOH H 6 . ? 43.865 9.592 -2.245 1.00 37.24 ? 1146 HOH A O 1 HETATM 3951 O O . HOH H 6 . ? 64.148 29.268 24.533 1.00 51.38 ? 1147 HOH A O 1 HETATM 3952 O O . HOH H 6 . ? 27.928 42.027 6.237 1.00 30.35 ? 1148 HOH A O 1 HETATM 3953 O O . HOH H 6 . ? 20.613 12.046 1.502 1.00 33.00 ? 1149 HOH A O 1 HETATM 3954 O O . HOH H 6 . ? 24.704 40.773 14.645 1.00 46.46 ? 1150 HOH A O 1 HETATM 3955 O O . HOH H 6 . ? 44.939 4.109 10.006 1.00 24.71 ? 1151 HOH A O 1 HETATM 3956 O O . HOH H 6 . ? 74.174 22.878 29.869 1.00 37.75 ? 1152 HOH A O 1 HETATM 3957 O O . HOH H 6 . ? 37.837 12.284 -23.834 1.00 38.42 ? 1153 HOH A O 1 HETATM 3958 O O . HOH H 6 . ? 36.505 16.143 -16.932 1.00 38.53 ? 1154 HOH A O 1 HETATM 3959 O O . HOH H 6 . ? 44.618 39.643 -5.430 1.00 34.60 ? 1155 HOH A O 1 HETATM 3960 O O . HOH H 6 . ? 62.962 5.672 28.928 1.00 28.77 ? 1156 HOH A O 1 HETATM 3961 O O . HOH H 6 . ? 38.761 47.245 22.120 1.00 39.86 ? 1157 HOH A O 1 HETATM 3962 O O . HOH H 6 . ? 20.758 12.743 12.477 1.00 42.21 ? 1158 HOH A O 1 HETATM 3963 O O . HOH H 6 . ? 62.731 26.920 13.436 1.00 42.89 ? 1159 HOH A O 1 HETATM 3964 O O . HOH H 6 . ? 19.187 27.597 -6.583 1.00 49.77 ? 1160 HOH A O 1 HETATM 3965 O O . HOH H 6 . ? 40.402 10.269 -1.325 1.00 48.38 ? 1161 HOH A O 1 HETATM 3966 O O . HOH H 6 . ? 25.915 33.471 -0.783 1.00 38.35 ? 1162 HOH A O 1 HETATM 3967 O O . HOH H 6 . ? 19.521 9.550 1.261 1.00 40.08 ? 1163 HOH A O 1 HETATM 3968 O O . HOH H 6 . ? 52.661 37.426 -18.136 1.00 51.75 ? 1164 HOH A O 1 HETATM 3969 O O . HOH H 6 . ? 68.353 16.846 24.028 1.00 47.62 ? 1165 HOH A O 1 HETATM 3970 O O . HOH H 6 . ? 38.623 8.191 -8.300 1.00 30.98 ? 1166 HOH A O 1 HETATM 3971 O O . HOH H 6 . ? 50.100 36.919 -9.761 1.00 63.92 ? 1167 HOH A O 1 HETATM 3972 O O . HOH H 6 . ? 15.372 15.724 14.057 1.00 31.27 ? 1168 HOH A O 1 HETATM 3973 O O . HOH H 6 . ? 32.497 52.733 18.931 1.00 47.64 ? 1169 HOH A O 1 HETATM 3974 O O . HOH H 6 . ? 65.630 0.307 20.576 1.00 27.26 ? 1170 HOH A O 1 HETATM 3975 O O . HOH H 6 . ? 61.327 1.154 29.733 1.00 22.99 ? 1171 HOH A O 1 HETATM 3976 O O . HOH H 6 . ? 36.725 33.148 10.026 1.00 25.35 ? 1172 HOH A O 1 HETATM 3977 O O . HOH H 6 . ? 54.818 46.005 13.420 1.00 38.78 ? 1173 HOH A O 1 HETATM 3978 O O . HOH H 6 . ? 24.503 12.985 12.644 1.00 30.30 ? 1174 HOH A O 1 HETATM 3979 O O . HOH H 6 . ? 40.862 16.911 -18.609 1.00 38.30 ? 1175 HOH A O 1 HETATM 3980 O O . HOH H 6 . ? 17.896 14.615 14.962 1.00 46.84 ? 1176 HOH A O 1 HETATM 3981 O O . HOH H 6 . ? 44.464 23.998 -17.692 1.00 50.10 ? 1177 HOH A O 1 HETATM 3982 O O . HOH H 6 . ? 33.822 24.689 -19.721 1.00 36.27 ? 1178 HOH A O 1 HETATM 3983 O O . HOH H 6 . ? 68.129 26.085 28.587 1.00 28.61 ? 1179 HOH A O 1 HETATM 3984 O O . HOH H 6 . ? 27.346 46.971 11.835 1.00 26.82 ? 1180 HOH A O 1 HETATM 3985 O O . HOH H 6 . ? 46.770 47.521 27.236 1.00 34.22 ? 1181 HOH A O 1 HETATM 3986 O O . HOH H 6 . ? 55.932 0.819 13.393 1.00 34.22 ? 1182 HOH A O 1 HETATM 3987 O O . HOH H 6 . ? 21.174 7.624 -5.390 1.00 33.16 ? 1183 HOH A O 1 HETATM 3988 O O . HOH H 6 . ? 59.926 11.935 0.765 1.00 37.90 ? 1184 HOH A O 1 HETATM 3989 O O . HOH H 6 . ? 60.855 42.655 27.448 1.00 32.06 ? 1185 HOH A O 1 HETATM 3990 O O . HOH H 6 . ? 23.391 12.173 15.114 1.00 39.70 ? 1186 HOH A O 1 HETATM 3991 O O . HOH H 6 . ? 56.714 33.249 23.027 1.00 31.47 ? 1187 HOH A O 1 HETATM 3992 O O . HOH H 6 . ? 51.752 -7.246 43.137 1.00 38.41 ? 1188 HOH A O 1 HETATM 3993 O O . HOH H 6 . ? 47.422 11.352 0.427 1.00 39.52 ? 1189 HOH A O 1 HETATM 3994 O O . HOH H 6 . ? 24.477 26.394 -0.953 1.00 30.20 ? 1190 HOH A O 1 HETATM 3995 O O . HOH H 6 . ? 53.796 -6.122 44.200 1.00 52.33 ? 1191 HOH A O 1 HETATM 3996 O O . HOH H 6 . ? 65.167 10.294 23.897 1.00 26.27 ? 1192 HOH A O 1 HETATM 3997 O O . HOH H 6 . ? 26.955 33.402 9.070 1.00 33.45 ? 1193 HOH A O 1 HETATM 3998 O O . HOH H 6 . ? 47.378 42.528 1.292 1.00 35.67 ? 1194 HOH A O 1 HETATM 3999 O O . HOH H 6 . ? 65.538 8.499 21.950 1.00 39.32 ? 1195 HOH A O 1 HETATM 4000 O O . HOH H 6 . ? 53.916 45.234 21.668 1.00 32.44 ? 1196 HOH A O 1 HETATM 4001 O O . HOH H 6 . ? 72.579 30.402 41.448 1.00 33.98 ? 1197 HOH A O 1 HETATM 4002 O O . HOH H 6 . ? 42.832 16.016 -16.944 1.00 40.61 ? 1198 HOH A O 1 HETATM 4003 O O . HOH H 6 . ? 35.914 45.883 4.865 1.00 40.62 ? 1199 HOH A O 1 HETATM 4004 O O . HOH H 6 . ? 43.398 4.849 11.276 1.00 28.07 ? 1200 HOH A O 1 HETATM 4005 O O . HOH H 6 . ? 40.795 31.400 -18.109 1.00 51.12 ? 1201 HOH A O 1 HETATM 4006 O O . HOH H 6 . ? 55.163 49.423 35.718 1.00 37.58 ? 1202 HOH A O 1 HETATM 4007 O O . HOH H 6 . ? 47.192 8.677 3.936 1.00 28.82 ? 1203 HOH A O 1 HETATM 4008 O O . HOH H 6 . ? 38.826 38.757 -7.598 1.00 33.99 ? 1204 HOH A O 1 HETATM 4009 O O . HOH H 6 . ? 27.542 30.288 -9.840 1.00 45.49 ? 1205 HOH A O 1 HETATM 4010 O O . HOH H 6 . ? 46.993 50.909 14.654 1.00 27.10 ? 1206 HOH A O 1 HETATM 4011 O O . HOH H 6 . ? 60.209 11.139 -1.509 1.00 50.07 ? 1207 HOH A O 1 HETATM 4012 O O . HOH H 6 . ? 57.451 47.714 29.033 1.00 41.91 ? 1208 HOH A O 1 HETATM 4013 O O . HOH H 6 . ? 44.787 46.872 -8.978 1.00 65.46 ? 1209 HOH A O 1 HETATM 4014 O O . HOH H 6 . ? 55.897 5.435 34.927 1.00 29.88 ? 1210 HOH A O 1 HETATM 4015 O O . HOH H 6 . ? 29.213 10.135 7.397 1.00 49.35 ? 1211 HOH A O 1 HETATM 4016 O O . HOH H 6 . ? 34.424 38.630 -7.952 1.00 35.25 ? 1212 HOH A O 1 HETATM 4017 O O . HOH H 6 . ? 59.802 43.920 25.503 1.00 32.05 ? 1213 HOH A O 1 HETATM 4018 O O . HOH H 6 . ? 74.174 27.989 36.256 1.00 30.21 ? 1214 HOH A O 1 HETATM 4019 O O . HOH H 6 . ? 66.075 35.882 29.551 1.00 41.27 ? 1215 HOH A O 1 HETATM 4020 O O . HOH H 6 . ? 60.261 43.983 33.094 1.00 40.59 ? 1216 HOH A O 1 HETATM 4021 O O . HOH H 6 . ? 40.045 12.357 -20.925 1.00 40.47 ? 1217 HOH A O 1 HETATM 4022 O O . HOH H 6 . ? 73.793 14.451 31.878 1.00 47.39 ? 1218 HOH A O 1 HETATM 4023 O O . HOH H 6 . ? 48.222 48.421 14.508 1.00 40.73 ? 1219 HOH A O 1 HETATM 4024 O O . HOH H 6 . ? 49.357 -5.728 30.448 1.00 40.65 ? 1220 HOH A O 1 HETATM 4025 O O . HOH H 6 . ? 59.953 4.629 7.925 1.00 41.76 ? 1221 HOH A O 1 HETATM 4026 O O . HOH H 6 . ? 30.529 45.245 17.800 1.00 51.52 ? 1222 HOH A O 1 HETATM 4027 O O . HOH H 6 . ? 8.083 12.059 5.816 1.00 34.09 ? 1223 HOH A O 1 HETATM 4028 O O . HOH H 6 . ? 46.632 3.549 7.763 1.00 49.64 ? 1224 HOH A O 1 HETATM 4029 O O . HOH H 6 . ? 37.987 26.451 -19.834 1.00 33.23 ? 1225 HOH A O 1 HETATM 4030 O O . HOH H 6 . ? 6.759 10.041 6.586 1.00 44.25 ? 1226 HOH A O 1 HETATM 4031 O O . HOH H 6 . ? 60.325 35.564 11.583 1.00 55.30 ? 1227 HOH A O 1 HETATM 4032 O O . HOH H 6 . ? 50.698 44.263 -7.202 1.00 48.65 ? 1228 HOH A O 1 HETATM 4033 O O . HOH H 6 . ? 40.423 45.643 -5.508 1.00 27.87 ? 1229 HOH A O 1 HETATM 4034 O O . HOH H 6 . ? 39.348 53.641 16.449 1.00 41.66 ? 1230 HOH A O 1 HETATM 4035 O O . HOH H 6 . ? 48.711 2.082 7.177 1.00 54.18 ? 1231 HOH A O 1 HETATM 4036 O O . HOH H 6 . ? 68.413 11.358 35.403 1.00 40.90 ? 1232 HOH A O 1 HETATM 4037 O O . HOH H 6 . ? 23.457 17.492 -6.894 1.00 31.55 ? 1233 HOH A O 1 HETATM 4038 O O . HOH H 6 . ? 40.461 49.295 19.733 1.00 44.50 ? 1234 HOH A O 1 HETATM 4039 O O . HOH H 6 . ? 60.229 16.601 6.147 1.00 46.76 ? 1235 HOH A O 1 HETATM 4040 O O . HOH H 6 . ? 64.918 8.205 30.086 1.00 29.65 ? 1236 HOH A O 1 HETATM 4041 O O . HOH H 6 . ? 62.885 2.897 29.122 1.00 39.35 ? 1237 HOH A O 1 HETATM 4042 O O . HOH H 6 . ? 21.178 9.335 7.288 1.00 36.17 ? 1238 HOH A O 1 HETATM 4043 O O . HOH H 6 . ? 45.199 44.348 -8.571 1.00 43.47 ? 1239 HOH A O 1 HETATM 4044 O O . HOH H 6 . ? 25.423 17.915 -11.982 1.00 36.92 ? 1240 HOH A O 1 HETATM 4045 O O . HOH H 6 . ? 26.898 12.215 -17.991 1.00 31.38 ? 1241 HOH A O 1 HETATM 4046 O O . HOH H 6 . ? 38.560 8.866 -0.823 1.00 48.90 ? 1242 HOH A O 1 HETATM 4047 O O . HOH H 6 . ? 27.090 8.968 14.604 1.00 74.21 ? 1243 HOH A O 1 HETATM 4048 O O . HOH H 6 . ? 50.775 5.873 -10.505 1.00 43.52 ? 1244 HOH A O 1 HETATM 4049 O O . HOH H 6 . ? 59.205 32.331 14.876 1.00 42.13 ? 1245 HOH A O 1 HETATM 4050 O O . HOH H 6 . ? 45.131 18.258 -16.099 1.00 39.11 ? 1246 HOH A O 1 HETATM 4051 O O . HOH H 6 . ? 61.036 12.264 9.540 1.00 37.98 ? 1247 HOH A O 1 HETATM 4052 O O . HOH H 6 . ? 61.836 36.989 9.808 1.00 43.80 ? 1248 HOH A O 1 HETATM 4053 O O . HOH H 6 . ? 52.394 0.467 15.274 1.00 37.78 ? 1249 HOH A O 1 HETATM 4054 O O . HOH H 6 . ? 42.921 6.948 9.427 1.00 36.95 ? 1250 HOH A O 1 HETATM 4055 O O . HOH H 6 . ? 50.658 7.679 4.054 1.00 52.89 ? 1251 HOH A O 1 HETATM 4056 O O . HOH H 6 . ? 44.526 6.815 7.028 1.00 49.48 ? 1252 HOH A O 1 HETATM 4057 O O . HOH H 6 . ? 25.042 25.706 -3.386 1.00 37.35 ? 1253 HOH A O 1 HETATM 4058 O O . HOH H 6 . ? 54.617 -2.891 20.352 1.00 47.36 ? 1254 HOH A O 1 HETATM 4059 O O . HOH H 6 . ? 32.718 31.223 28.362 1.00 22.35 ? 1255 HOH A O 1 HETATM 4060 O O . HOH H 6 . ? 36.737 9.521 1.076 1.00 46.04 ? 1256 HOH A O 1 HETATM 4061 O O . HOH H 6 . ? 48.153 47.137 18.559 1.00 38.41 ? 1257 HOH A O 1 HETATM 4062 O O . HOH H 6 . ? 71.788 33.640 41.419 1.00 41.09 ? 1258 HOH A O 1 HETATM 4063 O O . HOH H 6 . ? 59.896 24.300 6.871 1.00 27.94 ? 1259 HOH A O 1 HETATM 4064 O O . HOH H 6 . ? 65.420 32.476 28.542 1.00 34.18 ? 1260 HOH A O 1 HETATM 4065 O O . HOH H 6 . ? 54.722 42.787 5.417 1.00 36.16 ? 1261 HOH A O 1 HETATM 4066 O O . HOH H 6 . ? 64.493 0.394 23.721 1.00 38.18 ? 1262 HOH A O 1 HETATM 4067 O O . HOH H 6 . ? 47.790 33.924 -17.667 1.00 46.58 ? 1263 HOH A O 1 HETATM 4068 O O . HOH H 6 . ? 54.885 0.088 37.213 1.00 48.36 ? 1264 HOH A O 1 HETATM 4069 O O . HOH H 6 . ? 34.595 35.971 28.326 1.00 43.59 ? 1265 HOH A O 1 HETATM 4070 O O . HOH H 6 . ? 70.549 19.136 22.615 1.00 59.52 ? 1266 HOH A O 1 HETATM 4071 O O . HOH H 6 . ? 32.623 45.811 4.729 1.00 59.49 ? 1267 HOH A O 1 HETATM 4072 O O . HOH H 6 . ? 30.146 46.642 15.531 1.00 43.76 ? 1268 HOH A O 1 HETATM 4073 O O . HOH H 6 . ? 30.846 31.726 26.553 1.00 36.46 ? 1269 HOH A O 1 HETATM 4074 O O . HOH H 6 . ? 73.341 20.679 35.136 1.00 28.11 ? 1270 HOH A O 1 HETATM 4075 O O . HOH H 6 . ? 26.316 11.820 11.858 1.00 40.57 ? 1271 HOH A O 1 HETATM 4076 O O . HOH H 6 . ? 24.241 21.889 -9.815 1.00 51.08 ? 1272 HOH A O 1 HETATM 4077 O O . HOH H 6 . ? 43.778 0.782 -11.661 1.00 49.55 ? 1273 HOH A O 1 HETATM 4078 O O . HOH H 6 . ? 55.048 38.741 -9.953 1.00 38.93 ? 1274 HOH A O 1 HETATM 4079 O O . HOH H 6 . ? 69.286 13.162 30.514 1.00 33.40 ? 1275 HOH A O 1 HETATM 4080 O O . HOH H 6 . ? 62.652 22.360 7.653 1.00 45.73 ? 1276 HOH A O 1 HETATM 4081 O O . HOH H 6 . ? 55.219 43.646 23.676 1.00 26.00 ? 1277 HOH A O 1 HETATM 4082 O O . HOH H 6 . ? 54.779 41.298 22.717 1.00 32.33 ? 1278 HOH A O 1 HETATM 4083 O O . HOH H 6 . ? 56.524 41.257 8.507 1.00 33.40 ? 1279 HOH A O 1 HETATM 4084 O O . HOH H 6 . ? 58.102 43.827 23.707 1.00 37.56 ? 1280 HOH A O 1 HETATM 4085 O O . HOH H 6 . ? 30.923 32.242 -8.495 1.00 46.27 ? 1281 HOH A O 1 HETATM 4086 O O . HOH H 6 . ? 59.038 37.425 26.559 1.00 35.74 ? 1282 HOH A O 1 HETATM 4087 O O . HOH H 6 . ? 25.615 10.828 -9.429 1.00 42.38 ? 1283 HOH A O 1 HETATM 4088 O O . HOH H 6 . ? 41.425 9.945 -21.655 1.00 40.07 ? 1284 HOH A O 1 HETATM 4089 O O . HOH H 6 . ? 34.611 39.184 29.050 1.00 40.63 ? 1285 HOH A O 1 HETATM 4090 O O . HOH H 6 . ? 50.705 43.666 19.491 1.00 51.33 ? 1286 HOH A O 1 HETATM 4091 O O . HOH H 6 . ? 54.269 17.977 -19.951 1.00 40.06 ? 1287 HOH A O 1 HETATM 4092 O O . HOH H 6 . ? 62.621 -0.223 27.957 1.00 42.97 ? 1288 HOH A O 1 HETATM 4093 O O . HOH H 6 . ? 51.802 16.744 -18.565 1.00 51.25 ? 1289 HOH A O 1 HETATM 4094 O O . HOH H 6 . ? 44.008 9.434 6.652 1.00 46.48 ? 1290 HOH A O 1 HETATM 4095 O O . HOH H 6 . ? 56.672 18.958 -19.375 1.00 53.29 ? 1291 HOH A O 1 HETATM 4096 O O . HOH H 6 . ? 56.128 16.586 -20.678 1.00 39.91 ? 1292 HOH A O 1 HETATM 4097 O O . HOH H 6 . ? 31.061 36.179 -1.966 1.00 31.05 ? 1293 HOH A O 1 HETATM 4098 O O . HOH H 6 . ? 29.069 36.595 -3.795 1.00 90.12 ? 1294 HOH A O 1 HETATM 4099 O O . HOH H 6 . ? 24.365 7.221 -4.830 1.00 52.74 ? 1295 HOH A O 1 HETATM 4100 O O . HOH H 6 . ? 53.485 15.365 -17.009 1.00 53.12 ? 1296 HOH A O 1 HETATM 4101 O O . HOH H 6 . ? 53.578 40.510 20.281 1.00 56.38 ? 1297 HOH A O 1 HETATM 4102 O O . HOH H 6 . ? 33.761 22.211 -19.459 1.00 37.63 ? 1298 HOH A O 1 HETATM 4103 O O . HOH H 6 . ? 48.976 43.073 28.044 1.00 28.82 ? 1299 HOH A O 1 HETATM 4104 O O . HOH H 6 . ? 49.659 32.271 -16.620 1.00 43.95 ? 1300 HOH A O 1 HETATM 4105 O O . HOH H 6 . ? 46.041 0.576 -13.370 1.00 35.48 ? 1301 HOH A O 1 HETATM 4106 O O . HOH H 6 . ? 29.156 30.137 -11.747 1.00 50.85 ? 1302 HOH A O 1 HETATM 4107 O O . HOH H 6 . ? 48.905 23.208 -15.446 1.00 36.80 ? 1303 HOH A O 1 HETATM 4108 O O . HOH H 6 . ? 20.624 26.530 -3.732 1.00 44.23 ? 1304 HOH A O 1 HETATM 4109 O O . HOH H 6 . ? 29.899 26.321 -14.222 1.00 42.27 ? 1305 HOH A O 1 HETATM 4110 O O . HOH H 6 . ? 69.292 38.835 34.514 1.00 57.09 ? 1306 HOH A O 1 HETATM 4111 O O . HOH H 6 . ? 51.426 51.078 12.217 1.00 57.89 ? 1307 HOH A O 1 HETATM 4112 O O . HOH H 6 . ? 44.090 45.995 25.248 1.00 41.64 ? 1308 HOH A O 1 HETATM 4113 O O . HOH H 6 . ? 42.490 9.429 -4.374 1.00 46.95 ? 1309 HOH A O 1 HETATM 4114 O O . HOH H 6 . ? 60.832 15.458 12.431 1.00 48.69 ? 1310 HOH A O 1 HETATM 4115 O O . HOH H 6 . ? 36.992 31.282 -8.075 1.00 37.00 ? 1311 HOH A O 1 HETATM 4116 O O . HOH H 6 . ? 64.759 -1.580 30.058 1.00 56.17 ? 1312 HOH A O 1 HETATM 4117 O O . HOH H 6 . ? 47.914 -1.588 15.973 1.00 41.71 ? 1313 HOH A O 1 HETATM 4118 O O . HOH H 6 . ? 36.278 23.151 -24.021 1.00 51.26 ? 1314 HOH A O 1 HETATM 4119 O O . HOH H 6 . ? 66.305 39.506 36.689 1.00 40.69 ? 1315 HOH A O 1 HETATM 4120 O O . HOH H 6 . ? 54.193 11.801 -4.275 1.00 36.66 ? 1316 HOH A O 1 HETATM 4121 O O . HOH H 6 . ? 67.047 2.388 19.577 1.00 55.70 ? 1317 HOH A O 1 HETATM 4122 O O . HOH H 6 . ? 51.581 49.353 7.572 1.00 52.96 ? 1318 HOH A O 1 HETATM 4123 O O . HOH H 6 . ? 60.721 0.575 36.371 1.00 33.79 ? 1319 HOH A O 1 HETATM 4124 O O . HOH H 6 . ? 4.697 9.614 7.996 1.00 46.22 ? 1320 HOH A O 1 HETATM 4125 O O . HOH H 6 . ? 65.027 29.284 27.126 1.00 53.29 ? 1321 HOH A O 1 HETATM 4126 O O . HOH H 6 . ? 50.091 44.006 0.502 1.00 42.82 ? 1322 HOH A O 1 HETATM 4127 O O . HOH H 6 . ? 75.692 20.941 37.122 1.00 50.81 ? 1323 HOH A O 1 HETATM 4128 O O . HOH H 6 . ? 61.631 29.717 18.520 1.00 34.36 ? 1324 HOH A O 1 HETATM 4129 O O . HOH H 6 . ? 52.989 49.186 34.384 1.00 43.24 ? 1325 HOH A O 1 HETATM 4130 O O . HOH H 6 . ? 70.645 22.071 23.661 1.00 54.36 ? 1326 HOH A O 1 HETATM 4131 O O . HOH H 6 . ? 42.283 46.236 -7.977 1.00 39.81 ? 1327 HOH A O 1 HETATM 4132 O O . HOH H 6 . ? 55.360 -1.644 16.091 1.00 55.76 ? 1328 HOH A O 1 HETATM 4133 O O . HOH H 6 . ? 27.439 13.811 -19.904 1.00 48.83 ? 1329 HOH A O 1 HETATM 4134 O O . HOH H 6 . ? 59.299 -4.842 20.981 1.00 46.48 ? 1330 HOH A O 1 HETATM 4135 O O . HOH H 6 . ? 69.365 40.437 39.307 1.00 39.25 ? 1331 HOH A O 1 HETATM 4136 O O . HOH H 6 . ? 33.710 7.120 -1.555 1.00 42.55 ? 1332 HOH A O 1 HETATM 4137 O O . HOH H 6 . ? 60.960 36.460 28.294 1.00 33.06 ? 1333 HOH A O 1 HETATM 4138 O O . HOH H 6 . ? 72.639 35.623 38.508 1.00 40.26 ? 1334 HOH A O 1 HETATM 4139 O O . HOH H 6 . ? 57.620 48.385 36.312 1.00 45.95 ? 1335 HOH A O 1 HETATM 4140 O O . HOH H 6 . ? 47.252 31.451 -17.488 1.00 49.89 ? 1336 HOH A O 1 HETATM 4141 O O . HOH H 6 . ? 56.440 37.543 25.765 1.00 38.38 ? 1337 HOH A O 1 HETATM 4142 O O . HOH H 6 . ? 29.970 8.632 -1.016 1.00 48.78 ? 1338 HOH A O 1 HETATM 4143 O O . HOH H 6 . ? 59.969 34.270 24.466 1.00 38.76 ? 1339 HOH A O 1 HETATM 4144 O O . HOH H 6 . ? 36.954 16.697 -19.848 1.00 38.05 ? 1340 HOH A O 1 HETATM 4145 O O . HOH H 6 . ? 29.749 43.186 -3.471 1.00 34.79 ? 1341 HOH A O 1 HETATM 4146 O O . HOH H 6 . ? 66.380 6.848 26.586 1.00 44.49 ? 1342 HOH A O 1 HETATM 4147 O O . HOH H 6 . ? 43.777 10.739 -21.684 1.00 44.94 ? 1343 HOH A O 1 HETATM 4148 O O . HOH H 6 . ? 33.727 10.216 2.830 1.00 39.17 ? 1344 HOH A O 1 HETATM 4149 O O . HOH H 6 . ? 35.874 47.766 -0.987 1.00 49.56 ? 1345 HOH A O 1 HETATM 4150 O O . HOH H 6 . ? 59.857 14.171 2.301 1.00 67.13 ? 1346 HOH A O 1 HETATM 4151 O O . HOH H 6 . ? 53.657 11.619 -6.906 1.00 47.16 ? 1347 HOH A O 1 HETATM 4152 O O . HOH H 6 . ? 31.985 28.169 -16.829 1.00 39.85 ? 1348 HOH A O 1 HETATM 4153 O O . HOH H 6 . ? 24.399 14.761 -11.409 1.00 39.01 ? 1349 HOH A O 1 HETATM 4154 O O . HOH H 6 . ? 65.140 40.716 32.111 1.00 33.57 ? 1350 HOH A O 1 HETATM 4155 O O . HOH H 6 . ? 55.374 49.751 28.641 1.00 48.30 ? 1351 HOH A O 1 HETATM 4156 O O . HOH H 6 . ? 47.051 44.288 26.723 1.00 59.53 ? 1352 HOH A O 1 HETATM 4157 O O . HOH H 6 . ? 59.973 -5.287 39.258 1.00 50.20 ? 1353 HOH A O 1 HETATM 4158 O O . HOH H 6 . ? 59.914 20.334 6.008 1.00 42.72 ? 1354 HOH A O 1 HETATM 4159 O O . HOH H 6 . ? 54.499 43.365 19.020 1.00 68.78 ? 1355 HOH A O 1 HETATM 4160 O O . HOH H 6 . ? 61.489 5.213 36.581 1.00 50.09 ? 1356 HOH A O 1 HETATM 4161 O O . HOH H 6 . ? 56.892 4.228 4.554 1.00 80.61 ? 1357 HOH A O 1 HETATM 4162 O O . HOH H 6 . ? 71.357 31.160 29.560 1.00 50.83 ? 1358 HOH A O 1 HETATM 4163 O O . HOH H 6 . ? 55.098 38.689 19.086 1.00 47.78 ? 1359 HOH A O 1 HETATM 4164 O O . HOH H 6 . ? 25.920 19.471 -8.110 1.00 42.77 ? 1360 HOH A O 1 HETATM 4165 O O . HOH H 6 . ? 48.829 43.550 -9.270 1.00 46.18 ? 1361 HOH A O 1 HETATM 4166 O O . HOH H 6 . ? 60.200 10.355 8.046 1.00 34.25 ? 1362 HOH A O 1 HETATM 4167 O O . HOH H 6 . ? 45.427 42.235 27.202 1.00 52.54 ? 1363 HOH A O 1 HETATM 4168 O O . HOH H 6 . ? 63.339 13.833 -4.111 1.00 40.43 ? 1364 HOH A O 1 HETATM 4169 O O . HOH H 6 . ? 50.443 49.164 26.782 1.00 46.19 ? 1365 HOH A O 1 HETATM 4170 O O . HOH H 6 . ? 49.746 34.718 -9.314 1.00 49.62 ? 1366 HOH A O 1 HETATM 4171 O O . HOH H 6 . ? 60.260 22.589 4.589 1.00 29.54 ? 1367 HOH A O 1 HETATM 4172 O O . HOH H 6 . ? 70.727 35.565 40.028 1.00 44.16 ? 1368 HOH A O 1 HETATM 4173 O O . HOH H 6 . ? 31.493 52.680 11.532 1.00 55.58 ? 1369 HOH A O 1 HETATM 4174 O O . HOH H 6 . ? 54.811 37.736 12.747 1.00 38.38 ? 1370 HOH A O 1 HETATM 4175 O O . HOH H 6 . ? 56.675 37.976 17.424 1.00 43.15 ? 1371 HOH A O 1 HETATM 4176 O O . HOH H 6 . ? 24.232 18.253 -14.354 1.00 46.73 ? 1372 HOH A O 1 HETATM 4177 O O . HOH H 6 . ? 36.610 10.908 3.663 1.00 39.44 ? 1373 HOH A O 1 HETATM 4178 O O . HOH H 6 . ? 30.799 6.288 -8.944 1.00 34.87 ? 1374 HOH A O 1 HETATM 4179 O O . HOH H 6 . ? 36.395 36.904 -12.231 1.00 47.48 ? 1375 HOH A O 1 HETATM 4180 O O . HOH H 6 . ? 25.202 28.438 -9.477 1.00 47.05 ? 1376 HOH A O 1 HETATM 4181 O O . HOH H 6 . ? 45.465 50.112 4.222 1.00 56.10 ? 1377 HOH A O 1 HETATM 4182 O O . HOH H 6 . ? 15.032 20.409 11.363 1.00 31.12 ? 1378 HOH A O 1 HETATM 4183 O O . HOH H 6 . ? 36.817 52.271 17.843 1.00 44.82 ? 1379 HOH A O 1 HETATM 4184 O O . HOH H 6 . ? 41.628 20.585 -17.467 1.00 31.35 ? 1380 HOH A O 1 HETATM 4185 O O . HOH H 6 . ? 37.203 38.358 -9.523 1.00 45.60 ? 1381 HOH A O 1 HETATM 4186 O O . HOH H 6 . ? 51.790 47.328 5.873 1.00 58.50 ? 1382 HOH A O 1 HETATM 4187 O O . HOH H 6 . ? 50.881 28.863 -18.320 1.00 47.46 ? 1383 HOH A O 1 HETATM 4188 O O . HOH H 6 . ? 9.804 11.499 -0.479 1.00 58.23 ? 1384 HOH A O 1 HETATM 4189 O O . HOH H 6 . ? 61.228 33.208 12.089 1.00 65.92 ? 1385 HOH A O 1 HETATM 4190 O O . HOH H 6 . ? 62.213 13.819 13.783 1.00 46.77 ? 1386 HOH A O 1 HETATM 4191 O O . HOH H 6 . ? 55.369 41.046 17.906 1.00 72.68 ? 1387 HOH A O 1 HETATM 4192 O O . HOH H 6 . ? 23.417 14.888 -14.549 1.00 49.54 ? 1388 HOH A O 1 HETATM 4193 O O . HOH H 6 . ? 52.479 40.472 -4.087 1.00 42.89 ? 1389 HOH A O 1 HETATM 4194 O O . HOH H 6 . ? 29.955 34.475 -7.702 1.00 56.94 ? 1390 HOH A O 1 HETATM 4195 O O . HOH H 6 . ? 75.138 29.188 32.073 1.00 42.96 ? 1391 HOH A O 1 HETATM 4196 O O . HOH H 6 . ? 51.657 3.588 5.669 1.00 54.54 ? 1392 HOH A O 1 HETATM 4197 O O . HOH H 6 . ? 63.539 6.422 36.110 1.00 47.99 ? 1393 HOH A O 1 HETATM 4198 O O . HOH H 6 . ? 36.630 21.197 -26.337 1.00 50.48 ? 1394 HOH A O 1 HETATM 4199 O O . HOH H 6 . ? 24.731 33.894 -3.488 1.00 46.72 ? 1395 HOH A O 1 HETATM 4200 O O . HOH H 6 . ? 61.725 19.572 0.976 1.00 68.43 ? 1396 HOH A O 1 HETATM 4201 O O . HOH H 6 . ? 65.201 6.170 17.737 1.00 65.35 ? 1397 HOH A O 1 HETATM 4202 O O . HOH H 6 . ? 37.093 53.859 5.917 1.00 77.27 ? 1398 HOH A O 1 HETATM 4203 O O . HOH H 6 . ? 61.228 45.544 28.853 1.00 42.53 ? 1399 HOH A O 1 HETATM 4204 O O . HOH H 6 . ? 50.431 -0.751 12.760 1.00 44.68 ? 1400 HOH A O 1 HETATM 4205 O O . HOH H 6 . ? 62.383 8.870 11.653 1.00 63.07 ? 1401 HOH A O 1 HETATM 4206 O O . HOH H 6 . ? 39.797 40.388 -6.238 1.00 48.74 ? 1402 HOH A O 1 HETATM 4207 O O . HOH H 6 . ? 52.671 21.888 -20.385 1.00 44.62 ? 1403 HOH A O 1 HETATM 4208 O O . HOH H 6 . ? 71.479 22.372 27.531 1.00 38.84 ? 1404 HOH A O 1 HETATM 4209 O O . HOH H 6 . ? 56.468 38.599 14.787 1.00 47.18 ? 1405 HOH A O 1 HETATM 4210 O O . HOH H 6 . ? 37.886 51.056 8.256 1.00 44.90 ? 1406 HOH A O 1 HETATM 4211 O O . HOH H 6 . ? 64.314 17.460 -10.574 1.00 54.21 ? 1407 HOH A O 1 HETATM 4212 O O . HOH H 6 . ? 66.168 13.652 21.041 1.00 40.05 ? 1408 HOH A O 1 HETATM 4213 O O . HOH H 6 . ? 60.693 27.315 11.446 1.00 36.75 ? 1409 HOH A O 1 HETATM 4214 O O . HOH H 6 . ? 53.789 19.399 -21.997 1.00 57.35 ? 1410 HOH A O 1 HETATM 4215 O O . HOH H 6 . ? 49.752 -2.252 43.785 1.00 63.55 ? 1411 HOH A O 1 HETATM 4216 O O . HOH H 6 . ? 18.292 29.612 -3.817 1.00 44.87 ? 1412 HOH A O 1 HETATM 4217 O O . HOH H 6 . ? 13.836 13.355 -4.532 1.00 37.18 ? 1413 HOH A O 1 HETATM 4218 O O . HOH H 6 . ? 62.616 30.285 12.575 1.00 54.10 ? 1414 HOH A O 1 HETATM 4219 O O . HOH H 6 . ? 43.601 10.936 3.160 1.00 40.15 ? 1415 HOH A O 1 HETATM 4220 O O . HOH H 6 . ? 65.486 8.189 32.959 1.00 46.13 ? 1416 HOH A O 1 HETATM 4221 O O . HOH H 6 . ? 8.233 14.223 8.421 1.00 55.21 ? 1417 HOH A O 1 HETATM 4222 O O . HOH H 6 . ? 48.009 1.519 -10.995 1.00 41.96 ? 1418 HOH A O 1 HETATM 4223 O O . HOH H 6 . ? 24.515 38.459 10.515 1.00 47.96 ? 1419 HOH A O 1 HETATM 4224 O O . HOH H 6 . ? 44.623 -16.106 22.468 1.00 71.39 ? 1420 HOH A O 1 HETATM 4225 O O . HOH H 6 . ? 59.481 -2.885 14.695 1.00 61.73 ? 1421 HOH A O 1 HETATM 4226 O O . HOH H 6 . ? 14.369 16.421 10.106 1.00 47.30 ? 1422 HOH A O 1 HETATM 4227 O O . HOH H 6 . ? 29.557 9.888 15.126 1.00 29.24 ? 1423 HOH A O 1 HETATM 4228 O O . HOH H 6 . ? 45.618 5.825 4.359 1.00 59.58 ? 1424 HOH A O 1 HETATM 4229 O O . HOH H 6 . ? 52.666 -13.877 20.680 1.00 47.00 ? 1425 HOH A O 1 HETATM 4230 O O . HOH H 6 . ? 24.641 11.847 -13.526 1.00 41.93 ? 1426 HOH A O 1 HETATM 4231 O O . HOH H 6 . ? 28.948 6.884 -7.013 1.00 52.31 ? 1427 HOH A O 1 HETATM 4232 O O . HOH H 6 . ? 21.912 8.699 2.031 1.00 48.83 ? 1428 HOH A O 1 HETATM 4233 O O . HOH H 6 . ? 64.035 9.812 8.057 1.00 62.95 ? 1429 HOH A O 1 HETATM 4234 O O . HOH H 6 . ? 62.491 30.484 25.890 1.00 59.61 ? 1430 HOH A O 1 HETATM 4235 O O . HOH H 6 . ? 20.724 14.658 -17.149 1.00 93.75 ? 1431 HOH A O 1 HETATM 4236 O O . HOH H 6 . ? 74.128 20.297 31.239 1.00 56.43 ? 1432 HOH A O 1 HETATM 4237 O O . HOH H 6 . ? 41.069 8.609 2.788 1.00 52.18 ? 1433 HOH A O 1 HETATM 4238 O O . HOH H 6 . ? 37.616 34.365 -19.393 1.00 57.12 ? 1434 HOH A O 1 HETATM 4239 O O . HOH H 6 . ? 25.917 31.543 -4.551 1.00 40.75 ? 1435 HOH A O 1 HETATM 4240 O O . HOH H 6 . ? 53.918 32.458 -16.206 1.00 65.14 ? 1436 HOH A O 1 HETATM 4241 O O . HOH H 6 . ? 54.646 -18.496 25.767 1.00 49.84 ? 1437 HOH A O 1 HETATM 4242 O O . HOH H 6 . ? 63.540 38.360 40.310 1.00 59.65 ? 1438 HOH A O 1 HETATM 4243 O O . HOH H 6 . ? 55.872 -7.981 24.825 1.00 44.29 ? 1439 HOH A O 1 HETATM 4244 O O . HOH H 6 . ? 53.867 5.874 -15.385 1.00 56.85 ? 1440 HOH A O 1 HETATM 4245 O O . HOH H 6 . ? 48.108 48.753 2.664 1.00 53.79 ? 1441 HOH A O 1 HETATM 4246 O O . HOH H 6 . ? 24.648 29.027 -12.416 1.00 44.18 ? 1442 HOH A O 1 HETATM 4247 O O . HOH H 6 . ? 64.281 14.902 18.810 1.00 51.26 ? 1443 HOH A O 1 HETATM 4248 O O . HOH H 6 . ? 43.697 36.651 -23.354 1.00 73.16 ? 1444 HOH A O 1 HETATM 4249 O O . HOH H 6 . ? 59.964 -0.515 13.687 1.00 41.45 ? 1445 HOH A O 1 HETATM 4250 O O . HOH H 6 . ? 63.975 -8.649 38.534 1.00 72.33 ? 1446 HOH A O 1 HETATM 4251 O O . HOH H 6 . ? 23.166 26.259 -5.125 1.00 65.05 ? 1447 HOH A O 1 HETATM 4252 O O . HOH H 6 . ? 67.095 13.072 28.022 1.00 41.36 ? 1448 HOH A O 1 HETATM 4253 O O . HOH H 6 . ? 15.219 16.963 16.363 1.00 43.67 ? 1449 HOH A O 1 HETATM 4254 O O . HOH H 6 . ? 71.309 33.150 43.786 1.00 43.94 ? 1450 HOH A O 1 HETATM 4255 O O . HOH H 6 . ? 64.652 34.021 42.891 1.00 25.12 ? 1451 HOH A O 1 HETATM 4256 O O . HOH H 6 . ? 59.911 21.982 -1.071 1.00 24.47 ? 1452 HOH A O 1 HETATM 4257 O O . HOH H 6 . ? 40.823 47.005 3.431 1.00 37.11 ? 1453 HOH A O 1 HETATM 4258 O O . HOH H 6 . ? 73.126 35.575 35.763 1.00 56.00 ? 1454 HOH A O 1 HETATM 4259 O O . HOH H 6 . ? 60.941 13.934 5.550 1.00 60.36 ? 1455 HOH A O 1 HETATM 4260 O O . HOH H 6 . ? 52.479 49.315 20.736 1.00 53.24 ? 1456 HOH A O 1 HETATM 4261 O O . HOH H 6 . ? 41.006 -6.532 24.710 1.00 37.06 ? 1457 HOH A O 1 HETATM 4262 O O . HOH H 6 . ? 47.138 21.199 -16.789 1.00 46.51 ? 1458 HOH A O 1 HETATM 4263 O O . HOH H 6 . ? 26.520 35.590 7.678 1.00 47.04 ? 1459 HOH A O 1 HETATM 4264 O O . HOH H 6 . ? 40.083 25.917 -20.395 1.00 44.72 ? 1460 HOH A O 1 HETATM 4265 O O . HOH H 6 . ? 40.930 22.865 -18.436 1.00 49.62 ? 1461 HOH A O 1 HETATM 4266 O O . HOH H 6 . ? 68.291 24.291 26.659 1.00 45.39 ? 1462 HOH A O 1 HETATM 4267 O O . HOH H 6 . ? 39.950 5.646 -16.463 1.00 37.55 ? 1463 HOH A O 1 HETATM 4268 O O . HOH H 6 . ? 24.333 34.050 6.704 1.00 26.82 ? 1464 HOH A O 1 HETATM 4269 O O . HOH H 6 . ? 73.509 27.935 38.666 1.00 43.18 ? 1465 HOH A O 1 HETATM 4270 O O . HOH H 6 . ? 9.452 13.979 -1.599 1.00 64.49 ? 1466 HOH A O 1 HETATM 4271 O O . HOH H 6 . ? 50.254 13.784 -17.380 1.00 44.45 ? 1467 HOH A O 1 HETATM 4272 O O . HOH H 6 . ? 53.706 38.088 21.991 1.00 56.70 ? 1468 HOH A O 1 HETATM 4273 O O . HOH H 6 . ? 44.485 28.875 -18.233 1.00 49.96 ? 1469 HOH A O 1 HETATM 4274 O O . HOH H 6 . ? 38.089 8.118 -5.755 1.00 49.37 ? 1470 HOH A O 1 HETATM 4275 O O . HOH H 6 . ? 74.400 37.561 34.606 1.00 51.08 ? 1471 HOH A O 1 HETATM 4276 O O . HOH H 6 . ? 58.340 40.683 22.302 1.00 42.96 ? 1472 HOH A O 1 HETATM 4277 O O . HOH H 6 . ? 58.713 46.181 32.724 1.00 56.29 ? 1473 HOH A O 1 HETATM 4278 O O . HOH H 6 . ? 26.462 40.465 4.633 1.00 48.15 ? 1474 HOH A O 1 HETATM 4279 O O . HOH H 6 . ? 24.312 28.601 -1.701 1.00 41.46 ? 1475 HOH A O 1 HETATM 4280 O O . HOH H 6 . ? 68.012 6.785 17.576 1.00 60.22 ? 1476 HOH A O 1 HETATM 4281 O O . HOH H 6 . ? 18.972 31.864 -5.264 1.00 60.94 ? 1477 HOH A O 1 HETATM 4282 O O . HOH H 6 . ? 11.190 16.993 0.481 1.00 26.21 ? 1478 HOH A O 1 HETATM 4283 O O . HOH H 6 . ? 54.656 -15.997 24.799 1.00 41.77 ? 1479 HOH A O 1 HETATM 4284 O O . HOH H 6 . ? 32.199 26.703 -19.317 1.00 40.09 ? 1480 HOH A O 1 HETATM 4285 O O . HOH H 6 . ? 13.545 15.952 6.707 1.00 47.24 ? 1481 HOH A O 1 HETATM 4286 O O . HOH H 6 . ? 64.629 16.587 -5.475 1.00 73.86 ? 1482 HOH A O 1 HETATM 4287 O O . HOH H 6 . ? 72.693 23.094 20.654 1.00 62.65 ? 1483 HOH A O 1 HETATM 4288 O O . HOH H 6 . ? 47.485 -9.817 29.217 1.00 50.15 ? 1484 HOH A O 1 HETATM 4289 O O . HOH H 6 . ? 21.380 16.897 -11.282 1.00 51.03 ? 1485 HOH A O 1 HETATM 4290 O O . HOH H 6 . ? 41.992 23.110 -22.233 1.00 56.66 ? 1486 HOH A O 1 HETATM 4291 O O . HOH H 6 . ? 60.624 -4.195 29.034 1.00 40.47 ? 1487 HOH A O 1 HETATM 4292 O O . HOH H 6 . ? 48.774 8.253 -5.408 1.00 60.03 ? 1488 HOH A O 1 HETATM 4293 O O . HOH H 6 . ? 69.296 33.504 29.681 1.00 44.67 ? 1489 HOH A O 1 HETATM 4294 O O . HOH H 6 . ? 49.902 41.864 2.986 1.00 39.59 ? 1490 HOH A O 1 HETATM 4295 O O . HOH H 6 . ? 42.699 43.723 -7.035 1.00 35.86 ? 1491 HOH A O 1 HETATM 4296 O O . HOH H 6 . ? 60.191 -3.246 18.530 1.00 60.10 ? 1492 HOH A O 1 HETATM 4297 O O . HOH H 6 . ? 59.882 38.825 10.185 1.00 44.72 ? 1493 HOH A O 1 HETATM 4298 O O . HOH H 6 . ? 60.467 19.908 -12.467 1.00 45.21 ? 1494 HOH A O 1 HETATM 4299 O O . HOH H 6 . ? 18.520 23.134 -4.461 1.00 45.22 ? 1495 HOH A O 1 HETATM 4300 O O . HOH H 6 . ? 21.804 21.265 -8.769 1.00 45.64 ? 1496 HOH A O 1 HETATM 4301 O O . HOH H 6 . ? 42.169 33.733 -18.198 1.00 61.84 ? 1497 HOH A O 1 HETATM 4302 O O . HOH H 6 . ? 62.406 1.517 32.108 1.00 52.43 ? 1498 HOH A O 1 HETATM 4303 O O . HOH H 6 . ? 66.078 41.135 34.582 1.00 55.77 ? 1499 HOH A O 1 HETATM 4304 O O . HOH H 6 . ? 24.104 40.742 8.253 1.00 46.11 ? 1500 HOH A O 1 HETATM 4305 O O . HOH H 6 . ? 53.893 49.670 23.042 1.00 56.86 ? 1501 HOH A O 1 HETATM 4306 O O . HOH H 6 . ? 26.731 48.915 5.268 1.00 61.09 ? 1502 HOH A O 1 HETATM 4307 O O . HOH H 6 . ? 48.032 38.599 -10.029 1.00 64.55 ? 1503 HOH A O 1 HETATM 4308 O O . HOH H 6 . ? 49.719 35.564 -17.359 1.00 34.50 ? 1504 HOH A O 1 HETATM 4309 O O . HOH H 6 . ? 28.197 22.300 -17.231 1.00 39.98 ? 1505 HOH A O 1 HETATM 4310 O O . HOH H 6 . ? 33.045 45.441 -3.361 1.00 49.74 ? 1506 HOH A O 1 HETATM 4311 O O . HOH H 6 . ? 13.932 9.927 -5.332 1.00 59.70 ? 1507 HOH A O 1 HETATM 4312 O O . HOH H 6 . ? 69.826 18.739 17.648 1.00 79.39 ? 1508 HOH A O 1 HETATM 4313 O O . HOH H 6 . ? 48.056 52.792 13.185 1.00 46.91 ? 1509 HOH A O 1 HETATM 4314 O O . HOH H 6 . ? 61.296 40.696 11.485 1.00 70.28 ? 1510 HOH A O 1 HETATM 4315 O O . HOH H 6 . ? 63.960 43.223 31.901 1.00 46.47 ? 1511 HOH A O 1 HETATM 4316 O O . HOH H 6 . ? 51.249 27.685 -22.977 1.00 69.86 ? 1512 HOH A O 1 HETATM 4317 O O . HOH H 6 . ? 10.580 12.874 8.250 1.00 56.85 ? 1513 HOH A O 1 HETATM 4318 O O . HOH H 6 . ? 40.276 3.358 8.764 1.00 41.32 ? 1514 HOH A O 1 HETATM 4319 O O . HOH H 6 . ? 50.060 3.483 -8.687 1.00 50.10 ? 1515 HOH A O 1 HETATM 4320 O O . HOH H 6 . ? 50.223 41.473 -11.213 1.00 66.51 ? 1516 HOH A O 1 HETATM 4321 O O . HOH H 6 . ? 23.901 20.969 -13.632 1.00 53.55 ? 1517 HOH A O 1 HETATM 4322 O O . HOH H 6 . ? 34.810 45.535 -5.324 1.00 87.10 ? 1518 HOH A O 1 HETATM 4323 O O . HOH H 6 . ? 53.183 7.766 0.602 1.00 43.28 ? 1519 HOH A O 1 HETATM 4324 O O . HOH H 6 . ? 45.283 32.960 -17.903 1.00 54.45 ? 1520 HOH A O 1 HETATM 4325 O O . HOH H 6 . ? 42.742 5.166 -19.018 1.00 36.45 ? 1521 HOH A O 1 HETATM 4326 O O . HOH H 6 . ? 35.919 6.492 12.058 1.00 89.49 ? 1522 HOH A O 1 HETATM 4327 O O . HOH H 6 . ? 50.033 5.761 -5.685 1.00 92.00 ? 1523 HOH A O 1 HETATM 4328 O O . HOH H 6 . ? 24.705 13.395 -17.023 1.00 71.20 ? 1524 HOH A O 1 HETATM 4329 O O . HOH H 6 . ? 21.422 23.386 -7.091 1.00 54.48 ? 1525 HOH A O 1 HETATM 4330 O O . HOH H 6 . ? 28.258 40.642 2.691 1.00 36.59 ? 1526 HOH A O 1 HETATM 4331 O O . HOH H 6 . ? 54.194 31.988 -19.150 1.00 40.56 ? 1527 HOH A O 1 HETATM 4332 O O . HOH H 6 . ? 24.846 29.497 -6.021 1.00 47.66 ? 1528 HOH A O 1 HETATM 4333 O O . HOH H 6 . ? 38.531 15.569 -18.443 1.00 54.13 ? 1529 HOH A O 1 HETATM 4334 O O . HOH H 6 . ? 46.097 6.392 -2.710 1.00 45.46 ? 1530 HOH A O 1 HETATM 4335 O O . HOH H 6 . ? 35.229 41.709 -5.681 1.00 48.38 ? 1531 HOH A O 1 HETATM 4336 O O . HOH H 6 . ? 13.835 17.576 12.435 1.00 55.88 ? 1532 HOH A O 1 HETATM 4337 O O . HOH H 6 . ? 66.618 33.471 44.317 1.00 49.13 ? 1533 HOH A O 1 HETATM 4338 O O . HOH H 6 . ? 37.885 5.676 2.541 1.00 63.56 ? 1534 HOH A O 1 HETATM 4339 O O . HOH H 6 . ? 15.579 13.648 3.971 1.00 45.52 ? 1535 HOH A O 1 HETATM 4340 O O . HOH H 6 . ? 62.732 23.165 -2.302 1.00 76.10 ? 1536 HOH A O 1 HETATM 4341 O O . HOH H 6 . ? 61.036 12.962 -3.449 1.00 43.98 ? 1537 HOH A O 1 HETATM 4342 O O . HOH H 6 . ? 30.039 4.659 -10.730 1.00 52.44 ? 1538 HOH A O 1 HETATM 4343 O O . HOH H 6 . ? 26.985 41.929 0.243 1.00 57.42 ? 1539 HOH A O 1 HETATM 4344 O O . HOH H 6 . ? 39.706 48.297 -5.153 1.00 39.90 ? 1540 HOH A O 1 HETATM 4345 O O . HOH H 6 . ? 35.676 48.587 5.146 1.00 68.34 ? 1541 HOH A O 1 HETATM 4346 O O . HOH H 6 . ? 62.305 26.253 9.569 1.00 43.87 ? 1542 HOH A O 1 HETATM 4347 O O . HOH H 6 . ? 63.122 4.816 15.466 1.00 48.95 ? 1543 HOH A O 1 HETATM 4348 O O . HOH H 6 . ? 33.329 47.336 -6.913 1.00 60.00 ? 1544 HOH A O 1 HETATM 4349 O O . HOH H 6 . ? 34.583 6.766 -11.443 1.00 49.90 ? 1545 HOH A O 1 HETATM 4350 O O . HOH H 6 . ? 56.848 -17.478 27.182 1.00 56.56 ? 1546 HOH A O 1 HETATM 4351 O O . HOH H 6 . ? 52.067 11.219 -17.932 1.00 77.11 ? 1547 HOH A O 1 HETATM 4352 O O . HOH H 6 . ? 56.285 -14.804 26.521 1.00 53.21 ? 1548 HOH A O 1 HETATM 4353 O O . HOH H 6 . ? 26.154 8.102 6.505 1.00 57.04 ? 1549 HOH A O 1 HETATM 4354 O O . HOH H 6 . ? 41.491 2.590 -4.338 1.00 54.47 ? 1550 HOH A O 1 HETATM 4355 O O . HOH H 6 . ? 13.439 14.263 0.679 1.00 50.12 ? 1551 HOH A O 1 HETATM 4356 O O . HOH H 6 . ? 58.300 20.502 -13.575 1.00 52.49 ? 1552 HOH A O 1 HETATM 4357 O O . HOH H 6 . ? 76.125 32.940 34.295 1.00 50.82 ? 1553 HOH A O 1 HETATM 4358 O O . HOH H 6 . ? 52.823 8.290 -14.939 1.00 92.49 ? 1554 HOH A O 1 HETATM 4359 O O . HOH H 6 . ? 45.746 8.320 -0.868 1.00 68.05 ? 1555 HOH A O 1 HETATM 4360 O O . HOH H 6 . ? 65.406 25.448 -7.674 1.00 41.68 ? 1556 HOH A O 1 HETATM 4361 O O . HOH H 6 . ? 50.882 7.388 -3.556 1.00 66.92 ? 1557 HOH A O 1 HETATM 4362 O O . HOH H 6 . ? 40.187 7.473 -20.685 1.00 47.93 ? 1558 HOH A O 1 HETATM 4363 O O . HOH H 6 . ? 22.261 30.184 -6.914 1.00 62.95 ? 1559 HOH A O 1 HETATM 4364 O O . HOH H 6 . ? 38.901 12.292 5.930 1.00 35.51 ? 1560 HOH A O 1 HETATM 4365 O O . HOH H 6 . ? 68.297 35.245 43.059 1.00 52.04 ? 1561 HOH A O 1 HETATM 4366 O O . HOH H 6 . ? 35.351 7.210 0.745 1.00 58.53 ? 1562 HOH A O 1 HETATM 4367 O O . HOH H 6 . ? 52.606 50.375 15.712 1.00 65.19 ? 1563 HOH A O 1 HETATM 4368 O O . HOH H 6 . ? 38.964 32.505 -20.490 1.00 41.78 ? 1564 HOH A O 1 HETATM 4369 O O . HOH H 6 . ? 50.403 52.149 13.964 1.00 45.26 ? 1565 HOH A O 1 HETATM 4370 O O . HOH H 6 . ? 53.154 -10.934 26.444 1.00 49.51 ? 1566 HOH A O 1 HETATM 4371 O O . HOH H 6 . ? 22.705 11.485 11.883 1.00 44.26 ? 1567 HOH A O 1 HETATM 4372 O O . HOH H 6 . ? 45.881 0.962 -8.321 1.00 81.08 ? 1568 HOH A O 1 HETATM 4373 O O . HOH H 6 . ? 51.111 52.502 17.013 1.00 63.88 ? 1569 HOH A O 1 HETATM 4374 O O . HOH H 6 . ? 52.776 8.437 -11.103 1.00 51.96 ? 1570 HOH A O 1 HETATM 4375 O O . HOH H 6 . ? 45.562 41.674 -8.467 1.00 61.35 ? 1571 HOH A O 1 HETATM 4376 O O . HOH H 6 . ? 38.960 51.639 19.043 1.00 65.30 ? 1572 HOH A O 1 HETATM 4377 O O . HOH H 6 . ? 49.604 44.733 16.589 1.00 47.29 ? 1573 HOH A O 1 HETATM 4378 O O . HOH H 6 . ? 62.711 -1.826 15.512 1.00 51.07 ? 1574 HOH A O 1 HETATM 4379 O O . HOH H 6 . ? 57.418 26.742 -14.994 1.00 59.53 ? 1575 HOH A O 1 HETATM 4380 O O . HOH H 6 . ? 40.675 49.791 22.611 1.00 45.57 ? 1576 HOH A O 1 HETATM 4381 O O . HOH H 6 . ? 38.505 48.250 1.235 1.00 63.96 ? 1577 HOH A O 1 HETATM 4382 O O . HOH H 6 . ? 25.766 43.023 15.407 1.00 72.68 ? 1578 HOH A O 1 HETATM 4383 O O . HOH H 6 . ? 39.488 51.102 5.050 1.00 58.12 ? 1579 HOH A O 1 HETATM 4384 O O . HOH H 6 . ? 63.152 -6.284 39.545 1.00 59.56 ? 1580 HOH A O 1 HETATM 4385 O O . HOH H 6 . ? 62.623 14.525 -10.532 1.00 59.26 ? 1581 HOH A O 1 HETATM 4386 O O . HOH H 6 . ? 57.023 -19.749 23.674 1.00 49.47 ? 1582 HOH A O 1 HETATM 4387 O O . HOH H 6 . ? 55.390 40.782 1.978 1.00 40.34 ? 1583 HOH A O 1 HETATM 4388 O O . HOH H 6 . ? 43.954 21.350 -17.246 1.00 50.93 ? 1584 HOH A O 1 HETATM 4389 O O . HOH H 6 . ? 63.185 15.903 -0.049 1.00 60.44 ? 1585 HOH A O 1 HETATM 4390 O O . HOH H 6 . ? 56.963 35.671 22.469 1.00 54.74 ? 1586 HOH A O 1 HETATM 4391 O O . HOH H 6 . ? 48.557 49.491 17.438 1.00 58.85 ? 1587 HOH A O 1 HETATM 4392 O O . HOH H 6 . ? 62.422 46.277 24.242 1.00 58.88 ? 1588 HOH A O 1 HETATM 4393 O O . HOH H 6 . ? 7.173 13.933 3.593 1.00 42.10 ? 1589 HOH A O 1 HETATM 4394 O O . HOH H 6 . ? 44.502 1.335 8.956 1.00 49.29 ? 1590 HOH A O 1 HETATM 4395 O O . HOH H 6 . ? 51.292 -6.845 28.893 1.00 68.41 ? 1591 HOH A O 1 HETATM 4396 O O . HOH H 6 . ? 62.499 23.959 12.733 1.00 43.30 ? 1592 HOH A O 1 HETATM 4397 O O . HOH H 6 . ? 71.832 26.269 26.388 1.00 65.22 ? 1593 HOH A O 1 HETATM 4398 O O . HOH H 6 . ? 20.886 13.610 -10.716 1.00 47.82 ? 1594 HOH A O 1 HETATM 4399 O O . HOH H 6 . ? 41.153 32.127 -22.635 1.00 42.85 ? 1595 HOH A O 1 HETATM 4400 O O . HOH H 6 . ? 59.191 13.850 -11.955 1.00 54.89 ? 1596 HOH A O 1 HETATM 4401 O O . HOH H 6 . ? 59.608 16.400 1.019 1.00 51.23 ? 1597 HOH A O 1 HETATM 4402 O O . HOH H 6 . ? 76.693 28.634 33.891 1.00 58.02 ? 1598 HOH A O 1 HETATM 4403 O O . HOH H 6 . ? 66.043 -3.683 21.521 1.00 79.22 ? 1599 HOH A O 1 HETATM 4404 O O . HOH H 6 . ? 21.909 32.283 1.278 1.00 43.39 ? 1600 HOH A O 1 HETATM 4405 O O . HOH H 6 . ? 48.195 26.419 -16.563 1.00 49.12 ? 1601 HOH A O 1 HETATM 4406 O O . HOH H 6 . ? 74.206 14.080 27.784 1.00 74.91 ? 1602 HOH A O 1 HETATM 4407 O O . HOH H 6 . ? 32.490 10.409 -18.232 1.00 48.39 ? 1603 HOH A O 1 HETATM 4408 O O . HOH H 6 . ? 51.434 46.568 2.677 1.00 56.12 ? 1604 HOH A O 1 HETATM 4409 O O . HOH H 6 . ? 70.789 37.335 42.208 1.00 51.41 ? 1605 HOH A O 1 HETATM 4410 O O . HOH H 6 . ? 62.840 24.673 -5.691 1.00 39.84 ? 1606 HOH A O 1 HETATM 4411 O O . HOH H 6 . ? 58.238 29.274 1.649 1.00 28.85 ? 1607 HOH A O 1 HETATM 4412 O O . HOH H 6 . ? 34.071 13.095 5.124 1.00 65.09 ? 1608 HOH A O 1 HETATM 4413 O O . HOH H 6 . ? 44.595 37.320 -6.186 1.00 72.87 ? 1609 HOH A O 1 HETATM 4414 O O . HOH H 6 . ? 19.080 27.739 -1.038 1.00 73.94 ? 1610 HOH A O 1 HETATM 4415 O O . HOH H 6 . ? 52.012 41.012 1.753 1.00 44.62 ? 1611 HOH A O 1 HETATM 4416 O O . HOH H 6 . ? 62.872 23.989 1.131 1.00 48.93 ? 1612 HOH A O 1 HETATM 4417 O O . HOH H 6 . ? 48.574 46.407 -3.800 1.00 47.65 ? 1613 HOH A O 1 HETATM 4418 O O . HOH H 6 . ? 23.298 30.205 0.152 1.00 64.60 ? 1614 HOH A O 1 HETATM 4419 O O . HOH H 6 . ? 44.079 33.403 -20.538 1.00 57.94 ? 1615 HOH A O 1 # loop_ _pdbx_poly_seq_scheme.asym_id _pdbx_poly_seq_scheme.entity_id _pdbx_poly_seq_scheme.seq_id _pdbx_poly_seq_scheme.mon_id _pdbx_poly_seq_scheme.ndb_seq_num _pdbx_poly_seq_scheme.pdb_seq_num _pdbx_poly_seq_scheme.auth_seq_num _pdbx_poly_seq_scheme.pdb_mon_id _pdbx_poly_seq_scheme.auth_mon_id _pdbx_poly_seq_scheme.pdb_strand_id _pdbx_poly_seq_scheme.pdb_ins_code _pdbx_poly_seq_scheme.hetero A 1 1 ILE 1 1 1 ILE ILE A . n A 1 2 ILE 2 2 2 ILE ILE A . n A 1 3 PRO 3 3 3 PRO PRO A . n A 1 4 VAL 4 4 4 VAL VAL A . n A 1 5 GLU 5 5 5 GLU GLU A . n A 1 6 GLU 6 6 6 GLU GLU A . n A 1 7 GLU 7 7 7 GLU GLU A . n A 1 8 ASN 8 8 8 ASN ASN A . n A 1 9 PRO 9 9 9 PRO PRO A . n A 1 10 ASP 10 10 10 ASP ASP A . n A 1 11 PHE 11 11 11 PHE PHE A . n A 1 12 TRP 12 12 12 TRP TRP A . n A 1 13 ASN 13 13 13 ASN ASN A . n A 1 14 ARG 14 14 14 ARG ARG A . n A 1 15 GLU 15 15 15 GLU GLU A . n A 1 16 ALA 16 16 16 ALA ALA A . n A 1 17 ALA 17 17 17 ALA ALA A . n A 1 18 GLU 18 18 18 GLU GLU A . n A 1 19 ALA 19 19 19 ALA ALA A . n A 1 20 LEU 20 20 20 LEU LEU A . n A 1 21 GLY 21 21 21 GLY GLY A . n A 1 22 ALA 22 22 22 ALA ALA A . n A 1 23 ALA 23 23 23 ALA ALA A . n A 1 24 LYS 24 24 24 LYS LYS A . n A 1 25 LYS 25 25 25 LYS LYS A . n A 1 26 LEU 26 26 26 LEU LEU A . n A 1 27 GLN 27 27 27 GLN GLN A . n A 1 28 PRO 28 28 28 PRO PRO A . n A 1 29 ALA 29 29 29 ALA ALA A . n A 1 30 GLN 30 30 30 GLN GLN A . n A 1 31 THR 31 31 31 THR THR A . n A 1 32 ALA 32 32 32 ALA ALA A . n A 1 33 ALA 33 33 33 ALA ALA A . n A 1 34 LYS 34 34 34 LYS LYS A . n A 1 35 ASN 35 35 35 ASN ASN A . n A 1 36 LEU 36 36 36 LEU LEU A . n A 1 37 ILE 37 37 37 ILE ILE A . n A 1 38 ILE 38 38 38 ILE ILE A . n A 1 39 PHE 39 39 39 PHE PHE A . n A 1 40 LEU 40 40 40 LEU LEU A . n A 1 41 GLY 41 41 41 GLY GLY A . n A 1 42 ASP 42 42 42 ASP ASP A . n A 1 43 GLY 43 43 43 GLY GLY A . n A 1 44 MET 44 44 44 MET MET A . n A 1 45 GLY 45 45 45 GLY GLY A . n A 1 46 VAL 46 46 46 VAL VAL A . n A 1 47 SER 47 47 47 SER SER A . n A 1 48 THR 48 48 48 THR THR A . n A 1 49 VAL 49 49 49 VAL VAL A . n A 1 50 THR 50 50 50 THR THR A . n A 1 51 ALA 51 51 51 ALA ALA A . n A 1 52 ALA 52 52 52 ALA ALA A . n A 1 53 ARG 53 53 53 ARG ARG A . n A 1 54 ILE 54 54 54 ILE ILE A . n A 1 55 LEU 55 55 55 LEU LEU A . n A 1 56 LYS 56 56 56 LYS LYS A . n A 1 57 GLY 57 57 57 GLY GLY A . n A 1 58 GLN 58 58 58 GLN GLN A . n A 1 59 LYS 59 59 59 LYS LYS A . n A 1 60 LYS 60 60 60 LYS LYS A . n A 1 61 ASP 61 61 61 ASP ASP A . n A 1 62 LYS 62 62 62 LYS LYS A . n A 1 63 LEU 63 63 63 LEU LEU A . n A 1 64 GLY 64 64 64 GLY GLY A . n A 1 65 PRO 65 65 65 PRO PRO A . n A 1 66 GLU 66 66 66 GLU GLU A . n A 1 67 ILE 67 67 67 ILE ILE A . n A 1 68 PRO 68 68 68 PRO PRO A . n A 1 69 LEU 69 69 69 LEU LEU A . n A 1 70 ALA 70 70 70 ALA ALA A . n A 1 71 MET 71 71 71 MET MET A . n A 1 72 ASP 72 72 72 ASP ASP A . n A 1 73 ARG 73 73 73 ARG ARG A . n A 1 74 PHE 74 74 74 PHE PHE A . n A 1 75 PRO 75 75 75 PRO PRO A . n A 1 76 TYR 76 76 76 TYR TYR A . n A 1 77 VAL 77 77 77 VAL VAL A . n A 1 78 ALA 78 78 78 ALA ALA A . n A 1 79 LEU 79 79 79 LEU LEU A . n A 1 80 SER 80 80 80 SER SER A . n A 1 81 LYS 81 81 81 LYS LYS A . n A 1 82 THR 82 82 82 THR THR A . n A 1 83 TYR 83 83 83 TYR TYR A . n A 1 84 ASN 84 84 84 ASN ASN A . n A 1 85 VAL 85 85 85 VAL VAL A . n A 1 86 ASP 86 86 86 ASP ASP A . n A 1 87 LYS 87 87 87 LYS LYS A . n A 1 88 HIS 88 88 88 HIS HIS A . n A 1 89 VAL 89 89 89 VAL VAL A . n A 1 90 PRO 90 90 90 PRO PRO A . n A 1 91 ASP 91 91 91 ASP ASP A . n A 1 92 SEP 92 92 92 SEP SEP A . n A 1 93 GLY 93 93 93 GLY GLY A . n A 1 94 ALA 94 94 94 ALA ALA A . n A 1 95 THR 95 95 95 THR THR A . n A 1 96 ALA 96 96 96 ALA ALA A . n A 1 97 THR 97 97 97 THR THR A . n A 1 98 ALA 98 98 98 ALA ALA A . n A 1 99 TYR 99 99 99 TYR TYR A . n A 1 100 LEU 100 100 100 LEU LEU A . n A 1 101 CYS 101 101 101 CYS CYS A . n A 1 102 GLY 102 102 102 GLY GLY A . n A 1 103 VAL 103 103 103 VAL VAL A . n A 1 104 LYS 104 104 104 LYS LYS A . n A 1 105 GLY 105 105 105 GLY GLY A . n A 1 106 ASN 106 106 106 ASN ASN A . n A 1 107 PHE 107 107 107 PHE PHE A . n A 1 108 GLN 108 108 108 GLN GLN A . n A 1 109 THR 109 109 109 THR THR A . n A 1 110 ILE 110 110 110 ILE ILE A . n A 1 111 GLY 111 111 111 GLY GLY A . n A 1 112 LEU 112 112 112 LEU LEU A . n A 1 113 SER 113 113 113 SER SER A . n A 1 114 ALA 114 114 114 ALA ALA A . n A 1 115 ALA 115 115 115 ALA ALA A . n A 1 116 ALA 116 116 116 ALA ALA A . n A 1 117 ARG 117 117 117 ARG ARG A . n A 1 118 PHE 118 118 118 PHE PHE A . n A 1 119 ASN 119 119 119 ASN ASN A . n A 1 120 GLN 120 120 120 GLN GLN A . n A 1 121 CYS 121 121 121 CYS CYS A . n A 1 122 ASN 122 122 122 ASN ASN A . n A 1 123 THR 123 123 123 THR THR A . n A 1 124 THR 124 124 124 THR THR A . n A 1 125 ARG 125 125 125 ARG ARG A . n A 1 126 GLY 126 126 126 GLY GLY A . n A 1 127 ASN 127 127 127 ASN ASN A . n A 1 128 GLU 128 128 128 GLU GLU A . n A 1 129 VAL 129 129 129 VAL VAL A . n A 1 130 ILE 130 130 130 ILE ILE A . n A 1 131 SER 131 131 131 SER SER A . n A 1 132 VAL 132 132 132 VAL VAL A . n A 1 133 MET 133 133 133 MET MET A . n A 1 134 ASN 134 134 134 ASN ASN A . n A 1 135 ARG 135 135 135 ARG ARG A . n A 1 136 ALA 136 136 136 ALA ALA A . n A 1 137 LYS 137 137 137 LYS LYS A . n A 1 138 LYS 138 138 138 LYS LYS A . n A 1 139 ALA 139 139 139 ALA ALA A . n A 1 140 GLY 140 140 140 GLY GLY A . n A 1 141 LYS 141 141 141 LYS LYS A . n A 1 142 SER 142 142 142 SER SER A . n A 1 143 VAL 143 143 143 VAL VAL A . n A 1 144 GLY 144 144 144 GLY GLY A . n A 1 145 VAL 145 145 145 VAL VAL A . n A 1 146 VAL 146 146 146 VAL VAL A . n A 1 147 THR 147 147 147 THR THR A . n A 1 148 THR 148 148 148 THR THR A . n A 1 149 THR 149 149 149 THR THR A . n A 1 150 ARG 150 150 150 ARG ARG A . n A 1 151 VAL 151 151 151 VAL VAL A . n A 1 152 GLN 152 152 152 GLN GLN A . n A 1 153 HIS 153 153 153 HIS HIS A . n A 1 154 ALA 154 154 154 ALA ALA A . n A 1 155 SER 155 155 155 SER SER A . n A 1 156 PRO 156 156 156 PRO PRO A . n A 1 157 ALA 157 157 157 ALA ALA A . n A 1 158 GLY 158 158 158 GLY GLY A . n A 1 159 THR 159 159 159 THR THR A . n A 1 160 TYR 160 160 160 TYR TYR A . n A 1 161 ALA 161 161 161 ALA ALA A . n A 1 162 HIS 162 162 162 HIS HIS A . n A 1 163 THR 163 163 163 THR THR A . n A 1 164 VAL 164 164 164 VAL VAL A . n A 1 165 ASN 165 165 165 ASN ASN A . n A 1 166 ARG 166 166 166 ARG ARG A . n A 1 167 ASN 167 167 167 ASN ASN A . n A 1 168 TRP 168 168 168 TRP TRP A . n A 1 169 TYR 169 169 169 TYR TYR A . n A 1 170 SER 170 170 170 SER SER A . n A 1 171 ASP 171 171 171 ASP ASP A . n A 1 172 ALA 172 172 172 ALA ALA A . n A 1 173 ASP 173 173 173 ASP ASP A . n A 1 174 VAL 174 174 174 VAL VAL A . n A 1 175 PRO 175 175 175 PRO PRO A . n A 1 176 ALA 176 176 176 ALA ALA A . n A 1 177 SER 177 177 177 SER SER A . n A 1 178 ALA 178 178 178 ALA ALA A . n A 1 179 ARG 179 179 179 ARG ARG A . n A 1 180 GLN 180 180 180 GLN GLN A . n A 1 181 GLU 181 181 181 GLU GLU A . n A 1 182 GLY 182 182 182 GLY GLY A . n A 1 183 CYS 183 183 183 CYS CYS A . n A 1 184 GLN 184 184 184 GLN GLN A . n A 1 185 ASP 185 185 185 ASP ASP A . n A 1 186 ILE 186 186 186 ILE ILE A . n A 1 187 ALA 187 187 187 ALA ALA A . n A 1 188 THR 188 188 188 THR THR A . n A 1 189 GLN 189 189 189 GLN GLN A . n A 1 190 LEU 190 190 190 LEU LEU A . n A 1 191 ILE 191 191 191 ILE ILE A . n A 1 192 SER 192 192 192 SER SER A . n A 1 193 ASN 193 193 193 ASN ASN A . n A 1 194 MET 194 194 194 MET MET A . n A 1 195 ASP 195 195 195 ASP ASP A . n A 1 196 ILE 196 196 196 ILE ILE A . n A 1 197 ASP 197 197 197 ASP ASP A . n A 1 198 VAL 198 198 198 VAL VAL A . n A 1 199 ILE 199 199 199 ILE ILE A . n A 1 200 LEU 200 200 200 LEU LEU A . n A 1 201 GLY 201 201 201 GLY GLY A . n A 1 202 GLY 202 202 202 GLY GLY A . n A 1 203 GLY 203 203 203 GLY GLY A . n A 1 204 ARG 204 204 204 ARG ARG A . n A 1 205 LYS 205 205 205 LYS LYS A . n A 1 206 TYR 206 206 206 TYR TYR A . n A 1 207 MET 207 207 207 MET MET A . n A 1 208 PHE 208 208 208 PHE PHE A . n A 1 209 ARG 209 209 209 ARG ARG A . n A 1 210 MET 210 210 210 MET MET A . n A 1 211 GLY 211 211 211 GLY GLY A . n A 1 212 THR 212 212 212 THR THR A . n A 1 213 PRO 213 213 213 PRO PRO A . n A 1 214 ASP 214 214 214 ASP ASP A . n A 1 215 PRO 215 215 215 PRO PRO A . n A 1 216 GLU 216 216 216 GLU GLU A . n A 1 217 TYR 217 217 217 TYR TYR A . n A 1 218 PRO 218 218 218 PRO PRO A . n A 1 219 ASP 219 219 219 ASP ASP A . n A 1 220 ASP 220 220 220 ASP ASP A . n A 1 221 TYR 221 221 221 TYR TYR A . n A 1 222 SER 222 222 222 SER SER A . n A 1 223 GLN 223 223 223 GLN GLN A . n A 1 224 GLY 224 224 224 GLY GLY A . n A 1 225 GLY 225 225 225 GLY GLY A . n A 1 226 THR 226 226 226 THR THR A . n A 1 227 ARG 227 227 227 ARG ARG A . n A 1 228 LEU 228 228 228 LEU LEU A . n A 1 229 ASP 229 229 229 ASP ASP A . n A 1 230 GLY 230 230 230 GLY GLY A . n A 1 231 LYS 231 231 231 LYS LYS A . n A 1 232 ASN 232 232 232 ASN ASN A . n A 1 233 LEU 233 233 233 LEU LEU A . n A 1 234 VAL 234 234 234 VAL VAL A . n A 1 235 GLN 235 235 235 GLN GLN A . n A 1 236 GLU 236 236 236 GLU GLU A . n A 1 237 TRP 237 237 237 TRP TRP A . n A 1 238 LEU 238 238 238 LEU LEU A . n A 1 239 ALA 239 239 239 ALA ALA A . n A 1 240 LYS 240 240 240 LYS LYS A . n A 1 241 ARG 241 241 241 ARG ARG A . n A 1 242 GLN 242 242 242 GLN GLN A . n A 1 243 GLY 243 243 243 GLY GLY A . n A 1 244 ALA 244 244 244 ALA ALA A . n A 1 245 ARG 245 245 245 ARG ARG A . n A 1 246 TYR 246 246 246 TYR TYR A . n A 1 247 VAL 247 247 247 VAL VAL A . n A 1 248 TRP 248 248 248 TRP TRP A . n A 1 249 ASN 249 249 249 ASN ASN A . n A 1 250 ARG 250 250 250 ARG ARG A . n A 1 251 THR 251 251 251 THR THR A . n A 1 252 GLU 252 252 252 GLU GLU A . n A 1 253 LEU 253 253 253 LEU LEU A . n A 1 254 MET 254 254 254 MET MET A . n A 1 255 GLN 255 255 255 GLN GLN A . n A 1 256 ALA 256 256 256 ALA ALA A . n A 1 257 SER 257 257 257 SER SER A . n A 1 258 LEU 258 258 258 LEU LEU A . n A 1 259 ASP 259 259 259 ASP ASP A . n A 1 260 PRO 260 260 260 PRO PRO A . n A 1 261 SER 261 261 261 SER SER A . n A 1 262 VAL 262 262 262 VAL VAL A . n A 1 263 THR 263 263 263 THR THR A . n A 1 264 HIS 264 264 264 HIS HIS A . n A 1 265 LEU 265 265 265 LEU LEU A . n A 1 266 MET 266 266 266 MET MET A . n A 1 267 GLY 267 267 267 GLY GLY A . n A 1 268 LEU 268 268 268 LEU LEU A . n A 1 269 PHE 269 269 269 PHE PHE A . n A 1 270 GLU 270 270 270 GLU GLU A . n A 1 271 PRO 271 271 271 PRO PRO A . n A 1 272 GLY 272 272 272 GLY GLY A . n A 1 273 ASP 273 273 273 ASP ASP A . n A 1 274 MET 274 274 274 MET MET A . n A 1 275 LYS 275 275 275 LYS LYS A . n A 1 276 TYR 276 276 276 TYR TYR A . n A 1 277 GLU 277 277 277 GLU GLU A . n A 1 278 ILE 278 278 278 ILE ILE A . n A 1 279 HIS 279 279 279 HIS HIS A . n A 1 280 ARG 280 280 280 ARG ARG A . n A 1 281 ASP 281 281 281 ASP ASP A . n A 1 282 SER 282 282 282 SER SER A . n A 1 283 THR 283 283 283 THR THR A . n A 1 284 LEU 284 284 284 LEU LEU A . n A 1 285 ASP 285 285 285 ASP ASP A . n A 1 286 PRO 286 286 286 PRO PRO A . n A 1 287 SER 287 287 287 SER SER A . n A 1 288 LEU 288 288 288 LEU LEU A . n A 1 289 MET 289 289 289 MET MET A . n A 1 290 GLU 290 290 290 GLU GLU A . n A 1 291 MET 291 291 291 MET MET A . n A 1 292 THR 292 292 292 THR THR A . n A 1 293 GLU 293 293 293 GLU GLU A . n A 1 294 ALA 294 294 294 ALA ALA A . n A 1 295 ALA 295 295 295 ALA ALA A . n A 1 296 LEU 296 296 296 LEU LEU A . n A 1 297 ARG 297 297 297 ARG ARG A . n A 1 298 LEU 298 298 298 LEU LEU A . n A 1 299 LEU 299 299 299 LEU LEU A . n A 1 300 SER 300 300 300 SER SER A . n A 1 301 ARG 301 301 301 ARG ARG A . n A 1 302 ASN 302 302 302 ASN ASN A . n A 1 303 PRO 303 303 303 PRO PRO A . n A 1 304 ARG 304 304 304 ARG ARG A . n A 1 305 GLY 305 305 305 GLY GLY A . n A 1 306 PHE 306 306 306 PHE PHE A . n A 1 307 PHE 307 307 307 PHE PHE A . n A 1 308 LEU 308 308 308 LEU LEU A . n A 1 309 PHE 309 309 309 PHE PHE A . n A 1 310 VAL 310 310 310 VAL VAL A . n A 1 311 GLU 311 311 311 GLU GLU A . n A 1 312 GLY 312 312 312 GLY GLY A . n A 1 313 GLY 313 313 313 GLY GLY A . n A 1 314 ARG 314 314 314 ARG ARG A . n A 1 315 ILE 315 315 315 ILE ILE A . n A 1 316 ASP 316 316 316 ASP ASP A . n A 1 317 HIS 317 317 317 HIS HIS A . n A 1 318 GLY 318 318 318 GLY GLY A . n A 1 319 HIS 319 319 319 HIS HIS A . n A 1 320 HIS 320 320 320 HIS HIS A . n A 1 321 GLU 321 321 321 GLU GLU A . n A 1 322 SER 322 322 322 SER SER A . n A 1 323 ARG 323 323 323 ARG ARG A . n A 1 324 ALA 324 324 324 ALA ALA A . n A 1 325 TYR 325 325 325 TYR TYR A . n A 1 326 ARG 326 326 326 ARG ARG A . n A 1 327 ALA 327 327 327 ALA ALA A . n A 1 328 LEU 328 328 328 LEU LEU A . n A 1 329 THR 329 329 329 THR THR A . n A 1 330 GLU 330 330 330 GLU GLU A . n A 1 331 THR 331 331 331 THR THR A . n A 1 332 ILE 332 332 332 ILE ILE A . n A 1 333 MET 333 333 333 MET MET A . n A 1 334 PHE 334 334 334 PHE PHE A . n A 1 335 ASP 335 335 335 ASP ASP A . n A 1 336 ASP 336 336 336 ASP ASP A . n A 1 337 ALA 337 337 337 ALA ALA A . n A 1 338 ILE 338 338 338 ILE ILE A . n A 1 339 GLU 339 339 339 GLU GLU A . n A 1 340 ARG 340 340 340 ARG ARG A . n A 1 341 ALA 341 341 341 ALA ALA A . n A 1 342 GLY 342 342 342 GLY GLY A . n A 1 343 GLN 343 343 343 GLN GLN A . n A 1 344 LEU 344 344 344 LEU LEU A . n A 1 345 THR 345 345 345 THR THR A . n A 1 346 SER 346 346 346 SER SER A . n A 1 347 GLU 347 347 347 GLU GLU A . n A 1 348 GLU 348 348 348 GLU GLU A . n A 1 349 ASP 349 349 349 ASP ASP A . n A 1 350 THR 350 350 350 THR THR A . n A 1 351 LEU 351 351 351 LEU LEU A . n A 1 352 SER 352 352 352 SER SER A . n A 1 353 LEU 353 353 353 LEU LEU A . n A 1 354 VAL 354 354 354 VAL VAL A . n A 1 355 THR 355 355 355 THR THR A . n A 1 356 ALA 356 356 356 ALA ALA A . n A 1 357 ASP 357 357 357 ASP ASP A . n A 1 358 HIS 358 358 358 HIS HIS A . n A 1 359 SER 359 359 359 SER SER A . n A 1 360 HIS 360 360 360 HIS HIS A . n A 1 361 VAL 361 361 361 VAL VAL A . n A 1 362 PHE 362 362 362 PHE PHE A . n A 1 363 SER 363 363 363 SER SER A . n A 1 364 PHE 364 364 364 PHE PHE A . n A 1 365 GLY 365 365 365 GLY GLY A . n A 1 366 GLY 366 366 366 GLY GLY A . n A 1 367 TYR 367 367 367 TYR TYR A . n A 1 368 PRO 368 368 368 PRO PRO A . n A 1 369 LEU 369 369 369 LEU LEU A . n A 1 370 ARG 370 370 370 ARG ARG A . n A 1 371 GLY 371 371 371 GLY GLY A . n A 1 372 SER 372 372 372 SER SER A . n A 1 373 SER 373 373 373 SER SER A . n A 1 374 ILE 374 374 374 ILE ILE A . n A 1 375 PHE 375 375 375 PHE PHE A . n A 1 376 GLY 376 376 376 GLY GLY A . n A 1 377 LEU 377 377 377 LEU LEU A . n A 1 378 ALA 378 378 378 ALA ALA A . n A 1 379 PRO 379 379 379 PRO PRO A . n A 1 380 GLY 380 380 380 GLY GLY A . n A 1 381 LYS 381 381 381 LYS LYS A . n A 1 382 ALA 382 382 382 ALA ALA A . n A 1 383 ARG 383 383 383 ARG ARG A . n A 1 384 ASP 384 384 384 ASP ASP A . n A 1 385 ARG 385 385 385 ARG ARG A . n A 1 386 LYS 386 386 386 LYS LYS A . n A 1 387 ALA 387 387 387 ALA ALA A . n A 1 388 TYR 388 388 388 TYR TYR A . n A 1 389 THR 389 389 389 THR THR A . n A 1 390 VAL 390 390 390 VAL VAL A . n A 1 391 LEU 391 391 391 LEU LEU A . n A 1 392 LEU 392 392 392 LEU LEU A . n A 1 393 TYR 393 393 393 TYR TYR A . n A 1 394 GLY 394 394 394 GLY GLY A . n A 1 395 ASN 395 395 395 ASN ASN A . n A 1 396 GLY 396 396 396 GLY GLY A . n A 1 397 PRO 397 397 397 PRO PRO A . n A 1 398 GLY 398 398 398 GLY GLY A . n A 1 399 TYR 399 399 399 TYR TYR A . n A 1 400 VAL 400 400 400 VAL VAL A . n A 1 401 LEU 401 401 401 LEU LEU A . n A 1 402 LYS 402 402 402 LYS LYS A . n A 1 403 ASP 403 403 403 ASP ASP A . n A 1 404 GLY 404 404 404 GLY GLY A . n A 1 405 ALA 405 405 405 ALA ALA A . n A 1 406 ARG 406 406 406 ARG ARG A . n A 1 407 PRO 407 407 407 PRO PRO A . n A 1 408 ASP 408 408 408 ASP ASP A . n A 1 409 VAL 409 409 409 VAL VAL A . n A 1 410 THR 410 410 410 THR THR A . n A 1 411 GLU 411 411 411 GLU GLU A . n A 1 412 SER 412 412 412 SER SER A . n A 1 413 GLU 413 413 413 GLU GLU A . n A 1 414 SER 414 414 414 SER SER A . n A 1 415 GLY 415 415 415 GLY GLY A . n A 1 416 SER 416 416 416 SER SER A . n A 1 417 PRO 417 417 417 PRO PRO A . n A 1 418 GLU 418 418 418 GLU GLU A . n A 1 419 TYR 419 419 419 TYR TYR A . n A 1 420 ARG 420 420 420 ARG ARG A . n A 1 421 GLN 421 421 421 GLN GLN A . n A 1 422 GLN 422 422 422 GLN GLN A . n A 1 423 SER 423 423 423 SER SER A . n A 1 424 ALA 424 424 424 ALA ALA A . n A 1 425 VAL 425 425 425 VAL VAL A . n A 1 426 PRO 426 426 426 PRO PRO A . n A 1 427 LEU 427 427 427 LEU LEU A . n A 1 428 ASP 428 428 428 ASP ASP A . n A 1 429 GLU 429 429 429 GLU GLU A . n A 1 430 GLU 430 430 430 GLU GLU A . n A 1 431 THR 431 431 431 THR THR A . n A 1 432 HIS 432 432 432 HIS HIS A . n A 1 433 ALA 433 433 433 ALA ALA A . n A 1 434 GLY 434 434 434 GLY GLY A . n A 1 435 GLU 435 435 435 GLU GLU A . n A 1 436 ASP 436 436 436 ASP ASP A . n A 1 437 VAL 437 437 437 VAL VAL A . n A 1 438 ALA 438 438 438 ALA ALA A . n A 1 439 VAL 439 439 439 VAL VAL A . n A 1 440 PHE 440 440 440 PHE PHE A . n A 1 441 ALA 441 441 441 ALA ALA A . n A 1 442 ARG 442 442 442 ARG ARG A . n A 1 443 GLY 443 443 443 GLY GLY A . n A 1 444 PRO 444 444 444 PRO PRO A . n A 1 445 GLN 445 445 445 GLN GLN A . n A 1 446 ALA 446 446 446 ALA ALA A . n A 1 447 HIS 447 447 447 HIS HIS A . n A 1 448 LEU 448 448 448 LEU LEU A . n A 1 449 VAL 449 449 449 VAL VAL A . n A 1 450 HIS 450 450 450 HIS HIS A . n A 1 451 GLY 451 451 451 GLY GLY A . n A 1 452 VAL 452 452 452 VAL VAL A . n A 1 453 GLN 453 453 453 GLN GLN A . n A 1 454 GLU 454 454 454 GLU GLU A . n A 1 455 GLN 455 455 455 GLN GLN A . n A 1 456 THR 456 456 456 THR THR A . n A 1 457 PHE 457 457 457 PHE PHE A . n A 1 458 ILE 458 458 458 ILE ILE A . n A 1 459 ALA 459 459 459 ALA ALA A . n A 1 460 HIS 460 460 460 HIS HIS A . n A 1 461 VAL 461 461 461 VAL VAL A . n A 1 462 MET 462 462 462 MET MET A . n A 1 463 ALA 463 463 463 ALA ALA A . n A 1 464 PHE 464 464 464 PHE PHE A . n A 1 465 ALA 465 465 465 ALA ALA A . n A 1 466 ALA 466 466 466 ALA ALA A . n A 1 467 CYS 467 467 467 CYS CYS A . n A 1 468 LEU 468 468 468 LEU LEU A . n A 1 469 GLU 469 469 469 GLU GLU A . n A 1 470 PRO 470 470 470 PRO PRO A . n A 1 471 TYR 471 471 471 TYR TYR A . n A 1 472 THR 472 472 472 THR THR A . n A 1 473 ALA 473 473 473 ALA ALA A . n A 1 474 CYS 474 474 474 CYS CYS A . n A 1 475 ASP 475 475 475 ASP ASP A . n A 1 476 LEU 476 476 476 LEU LEU A . n A 1 477 ALA 477 477 477 ALA ALA A . n A 1 478 PRO 478 478 478 PRO PRO A . n A 1 479 PRO 479 479 479 PRO PRO A . n A 1 480 ALA 480 480 480 ALA ALA A . n A 1 481 GLY 481 481 ? ? ? A . n A 1 482 THR 482 482 ? ? ? A . n A 1 483 THR 483 483 ? ? ? A . n A 1 484 ASP 484 484 ? ? ? A . n # loop_ _pdbx_nonpoly_scheme.asym_id _pdbx_nonpoly_scheme.entity_id _pdbx_nonpoly_scheme.mon_id _pdbx_nonpoly_scheme.ndb_seq_num _pdbx_nonpoly_scheme.pdb_seq_num _pdbx_nonpoly_scheme.auth_seq_num _pdbx_nonpoly_scheme.pdb_mon_id _pdbx_nonpoly_scheme.auth_mon_id _pdbx_nonpoly_scheme.pdb_strand_id _pdbx_nonpoly_scheme.pdb_ins_code B 2 NAG 1 801 801 NAG NAG A . C 2 NAG 1 803 803 NAG NAG A . D 3 ZN 1 901 901 ZN ZN A . E 3 ZN 1 902 902 ZN ZN A . F 4 MG 1 903 903 MG MG A . G 5 CA 1 904 904 CA CA A . H 6 HOH 1 906 906 HOH HOH A . H 6 HOH 2 907 907 HOH HOH A . H 6 HOH 3 908 908 HOH HOH A . H 6 HOH 4 909 909 HOH HOH A . H 6 HOH 5 910 910 HOH HOH A . H 6 HOH 6 911 911 HOH HOH A . H 6 HOH 7 912 912 HOH HOH A . H 6 HOH 8 913 913 HOH HOH A . H 6 HOH 9 914 914 HOH HOH A . H 6 HOH 10 915 915 HOH HOH A . H 6 HOH 11 916 916 HOH HOH A . H 6 HOH 12 917 917 HOH HOH A . H 6 HOH 13 918 918 HOH HOH A . H 6 HOH 14 919 919 HOH HOH A . H 6 HOH 15 920 920 HOH HOH A . H 6 HOH 16 921 921 HOH HOH A . H 6 HOH 17 922 922 HOH HOH A . H 6 HOH 18 923 923 HOH HOH A . H 6 HOH 19 924 924 HOH HOH A . H 6 HOH 20 925 925 HOH HOH A . H 6 HOH 21 926 926 HOH HOH A . H 6 HOH 22 927 927 HOH HOH A . H 6 HOH 23 928 928 HOH HOH A . H 6 HOH 24 929 929 HOH HOH A . H 6 HOH 25 930 930 HOH HOH A . H 6 HOH 26 931 931 HOH HOH A . H 6 HOH 27 932 932 HOH HOH A . H 6 HOH 28 933 933 HOH HOH A . H 6 HOH 29 934 934 HOH HOH A . H 6 HOH 30 935 935 HOH HOH A . H 6 HOH 31 936 936 HOH HOH A . H 6 HOH 32 937 937 HOH HOH A . H 6 HOH 33 938 938 HOH HOH A . H 6 HOH 34 939 939 HOH HOH A . H 6 HOH 35 940 940 HOH HOH A . H 6 HOH 36 941 941 HOH HOH A . H 6 HOH 37 942 942 HOH HOH A . H 6 HOH 38 943 943 HOH HOH A . H 6 HOH 39 944 944 HOH HOH A . H 6 HOH 40 945 945 HOH HOH A . H 6 HOH 41 946 946 HOH HOH A . H 6 HOH 42 947 947 HOH HOH A . H 6 HOH 43 948 948 HOH HOH A . H 6 HOH 44 949 949 HOH HOH A . H 6 HOH 45 950 950 HOH HOH A . H 6 HOH 46 951 951 HOH HOH A . H 6 HOH 47 952 952 HOH HOH A . H 6 HOH 48 953 953 HOH HOH A . H 6 HOH 49 954 954 HOH HOH A . H 6 HOH 50 955 955 HOH HOH A . H 6 HOH 51 956 956 HOH HOH A . H 6 HOH 52 957 957 HOH HOH A . H 6 HOH 53 958 958 HOH HOH A . H 6 HOH 54 959 959 HOH HOH A . H 6 HOH 55 960 960 HOH HOH A . H 6 HOH 56 961 961 HOH HOH A . H 6 HOH 57 962 962 HOH HOH A . H 6 HOH 58 963 963 HOH HOH A . H 6 HOH 59 964 964 HOH HOH A . H 6 HOH 60 965 965 HOH HOH A . H 6 HOH 61 966 966 HOH HOH A . H 6 HOH 62 967 967 HOH HOH A . H 6 HOH 63 968 968 HOH HOH A . H 6 HOH 64 969 969 HOH HOH A . H 6 HOH 65 970 970 HOH HOH A . H 6 HOH 66 971 971 HOH HOH A . H 6 HOH 67 972 972 HOH HOH A . H 6 HOH 68 973 973 HOH HOH A . H 6 HOH 69 974 974 HOH HOH A . H 6 HOH 70 975 975 HOH HOH A . H 6 HOH 71 976 976 HOH HOH A . H 6 HOH 72 977 977 HOH HOH A . H 6 HOH 73 978 978 HOH HOH A . H 6 HOH 74 979 979 HOH HOH A . H 6 HOH 75 980 980 HOH HOH A . H 6 HOH 76 981 981 HOH HOH A . H 6 HOH 77 982 982 HOH HOH A . H 6 HOH 78 983 983 HOH HOH A . H 6 HOH 79 984 984 HOH HOH A . H 6 HOH 80 985 985 HOH HOH A . H 6 HOH 81 986 986 HOH HOH A . H 6 HOH 82 987 987 HOH HOH A . H 6 HOH 83 988 988 HOH HOH A . H 6 HOH 84 989 989 HOH HOH A . H 6 HOH 85 990 990 HOH HOH A . H 6 HOH 86 991 991 HOH HOH A . H 6 HOH 87 992 992 HOH HOH A . H 6 HOH 88 993 993 HOH HOH A . H 6 HOH 89 994 994 HOH HOH A . H 6 HOH 90 995 995 HOH HOH A . H 6 HOH 91 996 996 HOH HOH A . H 6 HOH 92 997 997 HOH HOH A . H 6 HOH 93 998 998 HOH HOH A . H 6 HOH 94 999 999 HOH HOH A . H 6 HOH 95 1000 1000 HOH HOH A . H 6 HOH 96 1001 1001 HOH HOH A . H 6 HOH 97 1002 1002 HOH HOH A . H 6 HOH 98 1003 1003 HOH HOH A . H 6 HOH 99 1004 1004 HOH HOH A . H 6 HOH 100 1005 1005 HOH HOH A . H 6 HOH 101 1006 1006 HOH HOH A . H 6 HOH 102 1007 1007 HOH HOH A . H 6 HOH 103 1008 1008 HOH HOH A . H 6 HOH 104 1009 1009 HOH HOH A . H 6 HOH 105 1010 1010 HOH HOH A . H 6 HOH 106 1011 1011 HOH HOH A . H 6 HOH 107 1012 1012 HOH HOH A . H 6 HOH 108 1013 1013 HOH HOH A . H 6 HOH 109 1014 1014 HOH HOH A . H 6 HOH 110 1015 1015 HOH HOH A . H 6 HOH 111 1016 1016 HOH HOH A . H 6 HOH 112 1017 1017 HOH HOH A . H 6 HOH 113 1018 1018 HOH HOH A . H 6 HOH 114 1019 1019 HOH HOH A . H 6 HOH 115 1020 1020 HOH HOH A . H 6 HOH 116 1021 1021 HOH HOH A . H 6 HOH 117 1022 1022 HOH HOH A . H 6 HOH 118 1023 1023 HOH HOH A . H 6 HOH 119 1024 1024 HOH HOH A . H 6 HOH 120 1025 1025 HOH HOH A . H 6 HOH 121 1026 1026 HOH HOH A . H 6 HOH 122 1027 1027 HOH HOH A . H 6 HOH 123 1028 1028 HOH HOH A . H 6 HOH 124 1029 1029 HOH HOH A . H 6 HOH 125 1030 1030 HOH HOH A . H 6 HOH 126 1031 1031 HOH HOH A . H 6 HOH 127 1032 1032 HOH HOH A . H 6 HOH 128 1033 1033 HOH HOH A . H 6 HOH 129 1034 1034 HOH HOH A . H 6 HOH 130 1035 1035 HOH HOH A . H 6 HOH 131 1036 1036 HOH HOH A . H 6 HOH 132 1037 1037 HOH HOH A . H 6 HOH 133 1038 1038 HOH HOH A . H 6 HOH 134 1039 1039 HOH HOH A . H 6 HOH 135 1040 1040 HOH HOH A . H 6 HOH 136 1041 1041 HOH HOH A . H 6 HOH 137 1042 1042 HOH HOH A . H 6 HOH 138 1043 1043 HOH HOH A . H 6 HOH 139 1044 1044 HOH HOH A . H 6 HOH 140 1045 1045 HOH HOH A . H 6 HOH 141 1046 1046 HOH HOH A . H 6 HOH 142 1047 1047 HOH HOH A . H 6 HOH 143 1048 1048 HOH HOH A . H 6 HOH 144 1049 1049 HOH HOH A . H 6 HOH 145 1050 1050 HOH HOH A . H 6 HOH 146 1051 1051 HOH HOH A . H 6 HOH 147 1052 1052 HOH HOH A . H 6 HOH 148 1053 1053 HOH HOH A . H 6 HOH 149 1054 1054 HOH HOH A . H 6 HOH 150 1055 1055 HOH HOH A . H 6 HOH 151 1056 1056 HOH HOH A . H 6 HOH 152 1057 1057 HOH HOH A . H 6 HOH 153 1058 1058 HOH HOH A . H 6 HOH 154 1059 1059 HOH HOH A . H 6 HOH 155 1060 1060 HOH HOH A . H 6 HOH 156 1061 1061 HOH HOH A . H 6 HOH 157 1062 1062 HOH HOH A . H 6 HOH 158 1063 1063 HOH HOH A . H 6 HOH 159 1064 1064 HOH HOH A . H 6 HOH 160 1065 1065 HOH HOH A . H 6 HOH 161 1066 1066 HOH HOH A . H 6 HOH 162 1067 1067 HOH HOH A . H 6 HOH 163 1068 1068 HOH HOH A . H 6 HOH 164 1069 1069 HOH HOH A . H 6 HOH 165 1070 1070 HOH HOH A . H 6 HOH 166 1071 1071 HOH HOH A . H 6 HOH 167 1072 1072 HOH HOH A . H 6 HOH 168 1073 1073 HOH HOH A . H 6 HOH 169 1074 1074 HOH HOH A . H 6 HOH 170 1075 1075 HOH HOH A . H 6 HOH 171 1076 1076 HOH HOH A . H 6 HOH 172 1077 1077 HOH HOH A . H 6 HOH 173 1078 1078 HOH HOH A . H 6 HOH 174 1079 1079 HOH HOH A . H 6 HOH 175 1080 1080 HOH HOH A . H 6 HOH 176 1081 1081 HOH HOH A . H 6 HOH 177 1082 1082 HOH HOH A . H 6 HOH 178 1083 1083 HOH HOH A . H 6 HOH 179 1084 1084 HOH HOH A . H 6 HOH 180 1085 1085 HOH HOH A . H 6 HOH 181 1086 1086 HOH HOH A . H 6 HOH 182 1087 1087 HOH HOH A . H 6 HOH 183 1088 1088 HOH HOH A . H 6 HOH 184 1089 1089 HOH HOH A . H 6 HOH 185 1090 1090 HOH HOH A . H 6 HOH 186 1091 1091 HOH HOH A . H 6 HOH 187 1092 1092 HOH HOH A . H 6 HOH 188 1093 1093 HOH HOH A . H 6 HOH 189 1094 1094 HOH HOH A . H 6 HOH 190 1095 1095 HOH HOH A . H 6 HOH 191 1096 1096 HOH HOH A . H 6 HOH 192 1097 1097 HOH HOH A . H 6 HOH 193 1098 1098 HOH HOH A . H 6 HOH 194 1099 1099 HOH HOH A . H 6 HOH 195 1100 1100 HOH HOH A . H 6 HOH 196 1101 1101 HOH HOH A . H 6 HOH 197 1102 1102 HOH HOH A . H 6 HOH 198 1103 1103 HOH HOH A . H 6 HOH 199 1104 1104 HOH HOH A . H 6 HOH 200 1105 1105 HOH HOH A . H 6 HOH 201 1106 1106 HOH HOH A . H 6 HOH 202 1107 1107 HOH HOH A . H 6 HOH 203 1108 1108 HOH HOH A . H 6 HOH 204 1109 1109 HOH HOH A . H 6 HOH 205 1110 1110 HOH HOH A . H 6 HOH 206 1111 1111 HOH HOH A . H 6 HOH 207 1112 1112 HOH HOH A . H 6 HOH 208 1113 1113 HOH HOH A . H 6 HOH 209 1114 1114 HOH HOH A . H 6 HOH 210 1115 1115 HOH HOH A . H 6 HOH 211 1116 1116 HOH HOH A . H 6 HOH 212 1117 1117 HOH HOH A . H 6 HOH 213 1118 1118 HOH HOH A . H 6 HOH 214 1119 1119 HOH HOH A . H 6 HOH 215 1120 1120 HOH HOH A . H 6 HOH 216 1121 1121 HOH HOH A . H 6 HOH 217 1122 1122 HOH HOH A . H 6 HOH 218 1123 1123 HOH HOH A . H 6 HOH 219 1124 1124 HOH HOH A . H 6 HOH 220 1125 1125 HOH HOH A . H 6 HOH 221 1126 1126 HOH HOH A . H 6 HOH 222 1127 1127 HOH HOH A . H 6 HOH 223 1128 1128 HOH HOH A . H 6 HOH 224 1129 1129 HOH HOH A . H 6 HOH 225 1130 1130 HOH HOH A . H 6 HOH 226 1131 1131 HOH HOH A . H 6 HOH 227 1132 1132 HOH HOH A . H 6 HOH 228 1133 1133 HOH HOH A . H 6 HOH 229 1134 1134 HOH HOH A . H 6 HOH 230 1135 1135 HOH HOH A . H 6 HOH 231 1136 1136 HOH HOH A . H 6 HOH 232 1137 1137 HOH HOH A . H 6 HOH 233 1138 1138 HOH HOH A . H 6 HOH 234 1139 1139 HOH HOH A . H 6 HOH 235 1140 1140 HOH HOH A . H 6 HOH 236 1141 1141 HOH HOH A . H 6 HOH 237 1142 1142 HOH HOH A . H 6 HOH 238 1143 1143 HOH HOH A . H 6 HOH 239 1144 1144 HOH HOH A . H 6 HOH 240 1145 1145 HOH HOH A . H 6 HOH 241 1146 1146 HOH HOH A . H 6 HOH 242 1147 1147 HOH HOH A . H 6 HOH 243 1148 1148 HOH HOH A . H 6 HOH 244 1149 1149 HOH HOH A . H 6 HOH 245 1150 1150 HOH HOH A . H 6 HOH 246 1151 1151 HOH HOH A . H 6 HOH 247 1152 1152 HOH HOH A . H 6 HOH 248 1153 1153 HOH HOH A . H 6 HOH 249 1154 1154 HOH HOH A . H 6 HOH 250 1155 1155 HOH HOH A . H 6 HOH 251 1156 1156 HOH HOH A . H 6 HOH 252 1157 1157 HOH HOH A . H 6 HOH 253 1158 1158 HOH HOH A . H 6 HOH 254 1159 1159 HOH HOH A . H 6 HOH 255 1160 1160 HOH HOH A . H 6 HOH 256 1161 1161 HOH HOH A . H 6 HOH 257 1162 1162 HOH HOH A . H 6 HOH 258 1163 1163 HOH HOH A . H 6 HOH 259 1164 1164 HOH HOH A . H 6 HOH 260 1165 1165 HOH HOH A . H 6 HOH 261 1166 1166 HOH HOH A . H 6 HOH 262 1167 1167 HOH HOH A . H 6 HOH 263 1168 1168 HOH HOH A . H 6 HOH 264 1169 1169 HOH HOH A . H 6 HOH 265 1170 1170 HOH HOH A . H 6 HOH 266 1171 1171 HOH HOH A . H 6 HOH 267 1172 1172 HOH HOH A . H 6 HOH 268 1173 1173 HOH HOH A . H 6 HOH 269 1174 1174 HOH HOH A . H 6 HOH 270 1175 1175 HOH HOH A . H 6 HOH 271 1176 1176 HOH HOH A . H 6 HOH 272 1177 1177 HOH HOH A . H 6 HOH 273 1178 1178 HOH HOH A . H 6 HOH 274 1179 1179 HOH HOH A . H 6 HOH 275 1180 1180 HOH HOH A . H 6 HOH 276 1181 1181 HOH HOH A . H 6 HOH 277 1182 1182 HOH HOH A . H 6 HOH 278 1183 1183 HOH HOH A . H 6 HOH 279 1184 1184 HOH HOH A . H 6 HOH 280 1185 1185 HOH HOH A . H 6 HOH 281 1186 1186 HOH HOH A . H 6 HOH 282 1187 1187 HOH HOH A . H 6 HOH 283 1188 1188 HOH HOH A . H 6 HOH 284 1189 1189 HOH HOH A . H 6 HOH 285 1190 1190 HOH HOH A . H 6 HOH 286 1191 1191 HOH HOH A . H 6 HOH 287 1192 1192 HOH HOH A . H 6 HOH 288 1193 1193 HOH HOH A . H 6 HOH 289 1194 1194 HOH HOH A . H 6 HOH 290 1195 1195 HOH HOH A . H 6 HOH 291 1196 1196 HOH HOH A . H 6 HOH 292 1197 1197 HOH HOH A . H 6 HOH 293 1198 1198 HOH HOH A . H 6 HOH 294 1199 1199 HOH HOH A . H 6 HOH 295 1200 1200 HOH HOH A . H 6 HOH 296 1201 1201 HOH HOH A . H 6 HOH 297 1202 1202 HOH HOH A . H 6 HOH 298 1203 1203 HOH HOH A . H 6 HOH 299 1204 1204 HOH HOH A . H 6 HOH 300 1205 1205 HOH HOH A . H 6 HOH 301 1206 1206 HOH HOH A . H 6 HOH 302 1207 1207 HOH HOH A . H 6 HOH 303 1208 1208 HOH HOH A . H 6 HOH 304 1209 1209 HOH HOH A . H 6 HOH 305 1210 1210 HOH HOH A . H 6 HOH 306 1211 1211 HOH HOH A . H 6 HOH 307 1212 1212 HOH HOH A . H 6 HOH 308 1213 1213 HOH HOH A . H 6 HOH 309 1214 1214 HOH HOH A . H 6 HOH 310 1215 1215 HOH HOH A . H 6 HOH 311 1216 1216 HOH HOH A . H 6 HOH 312 1217 1217 HOH HOH A . H 6 HOH 313 1218 1218 HOH HOH A . H 6 HOH 314 1219 1219 HOH HOH A . H 6 HOH 315 1220 1220 HOH HOH A . H 6 HOH 316 1221 1221 HOH HOH A . H 6 HOH 317 1222 1222 HOH HOH A . H 6 HOH 318 1223 1223 HOH HOH A . H 6 HOH 319 1224 1224 HOH HOH A . H 6 HOH 320 1225 1225 HOH HOH A . H 6 HOH 321 1226 1226 HOH HOH A . H 6 HOH 322 1227 1227 HOH HOH A . H 6 HOH 323 1228 1228 HOH HOH A . H 6 HOH 324 1229 1229 HOH HOH A . H 6 HOH 325 1230 1230 HOH HOH A . H 6 HOH 326 1231 1231 HOH HOH A . H 6 HOH 327 1232 1232 HOH HOH A . H 6 HOH 328 1233 1233 HOH HOH A . H 6 HOH 329 1234 1234 HOH HOH A . H 6 HOH 330 1235 1235 HOH HOH A . H 6 HOH 331 1236 1236 HOH HOH A . H 6 HOH 332 1237 1237 HOH HOH A . H 6 HOH 333 1238 1238 HOH HOH A . H 6 HOH 334 1239 1239 HOH HOH A . H 6 HOH 335 1240 1240 HOH HOH A . H 6 HOH 336 1241 1241 HOH HOH A . H 6 HOH 337 1242 1242 HOH HOH A . H 6 HOH 338 1243 1243 HOH HOH A . H 6 HOH 339 1244 1244 HOH HOH A . H 6 HOH 340 1245 1245 HOH HOH A . H 6 HOH 341 1246 1246 HOH HOH A . H 6 HOH 342 1247 1247 HOH HOH A . H 6 HOH 343 1248 1248 HOH HOH A . H 6 HOH 344 1249 1249 HOH HOH A . H 6 HOH 345 1250 1250 HOH HOH A . H 6 HOH 346 1251 1251 HOH HOH A . H 6 HOH 347 1252 1252 HOH HOH A . H 6 HOH 348 1253 1253 HOH HOH A . H 6 HOH 349 1254 1254 HOH HOH A . H 6 HOH 350 1255 1255 HOH HOH A . H 6 HOH 351 1256 1256 HOH HOH A . H 6 HOH 352 1257 1257 HOH HOH A . H 6 HOH 353 1258 1258 HOH HOH A . H 6 HOH 354 1259 1259 HOH HOH A . H 6 HOH 355 1260 1260 HOH HOH A . H 6 HOH 356 1261 1261 HOH HOH A . H 6 HOH 357 1262 1262 HOH HOH A . H 6 HOH 358 1263 1263 HOH HOH A . H 6 HOH 359 1264 1264 HOH HOH A . H 6 HOH 360 1265 1265 HOH HOH A . H 6 HOH 361 1266 1266 HOH HOH A . H 6 HOH 362 1267 1267 HOH HOH A . H 6 HOH 363 1268 1268 HOH HOH A . H 6 HOH 364 1269 1269 HOH HOH A . H 6 HOH 365 1270 1270 HOH HOH A . H 6 HOH 366 1271 1271 HOH HOH A . H 6 HOH 367 1272 1272 HOH HOH A . H 6 HOH 368 1273 1273 HOH HOH A . H 6 HOH 369 1274 1274 HOH HOH A . H 6 HOH 370 1275 1275 HOH HOH A . H 6 HOH 371 1276 1276 HOH HOH A . H 6 HOH 372 1277 1277 HOH HOH A . H 6 HOH 373 1278 1278 HOH HOH A . H 6 HOH 374 1279 1279 HOH HOH A . H 6 HOH 375 1280 1280 HOH HOH A . H 6 HOH 376 1281 1281 HOH HOH A . H 6 HOH 377 1282 1282 HOH HOH A . H 6 HOH 378 1283 1283 HOH HOH A . H 6 HOH 379 1284 1284 HOH HOH A . H 6 HOH 380 1285 1285 HOH HOH A . H 6 HOH 381 1286 1286 HOH HOH A . H 6 HOH 382 1287 1287 HOH HOH A . H 6 HOH 383 1288 1288 HOH HOH A . H 6 HOH 384 1289 1289 HOH HOH A . H 6 HOH 385 1290 1290 HOH HOH A . H 6 HOH 386 1291 1291 HOH HOH A . H 6 HOH 387 1292 1292 HOH HOH A . H 6 HOH 388 1293 1293 HOH HOH A . H 6 HOH 389 1294 1294 HOH HOH A . H 6 HOH 390 1295 1295 HOH HOH A . H 6 HOH 391 1296 1296 HOH HOH A . H 6 HOH 392 1297 1297 HOH HOH A . H 6 HOH 393 1298 1298 HOH HOH A . H 6 HOH 394 1299 1299 HOH HOH A . H 6 HOH 395 1300 1300 HOH HOH A . H 6 HOH 396 1301 1301 HOH HOH A . H 6 HOH 397 1302 1302 HOH HOH A . H 6 HOH 398 1303 1303 HOH HOH A . H 6 HOH 399 1304 1304 HOH HOH A . H 6 HOH 400 1305 1305 HOH HOH A . H 6 HOH 401 1306 1306 HOH HOH A . H 6 HOH 402 1307 1307 HOH HOH A . H 6 HOH 403 1308 1308 HOH HOH A . H 6 HOH 404 1309 1309 HOH HOH A . H 6 HOH 405 1310 1310 HOH HOH A . H 6 HOH 406 1311 1311 HOH HOH A . H 6 HOH 407 1312 1312 HOH HOH A . H 6 HOH 408 1313 1313 HOH HOH A . H 6 HOH 409 1314 1314 HOH HOH A . H 6 HOH 410 1315 1315 HOH HOH A . H 6 HOH 411 1316 1316 HOH HOH A . H 6 HOH 412 1317 1317 HOH HOH A . H 6 HOH 413 1318 1318 HOH HOH A . H 6 HOH 414 1319 1319 HOH HOH A . H 6 HOH 415 1320 1320 HOH HOH A . H 6 HOH 416 1321 1321 HOH HOH A . H 6 HOH 417 1322 1322 HOH HOH A . H 6 HOH 418 1323 1323 HOH HOH A . H 6 HOH 419 1324 1324 HOH HOH A . H 6 HOH 420 1325 1325 HOH HOH A . H 6 HOH 421 1326 1326 HOH HOH A . H 6 HOH 422 1327 1327 HOH HOH A . H 6 HOH 423 1328 1328 HOH HOH A . H 6 HOH 424 1329 1329 HOH HOH A . H 6 HOH 425 1330 1330 HOH HOH A . H 6 HOH 426 1331 1331 HOH HOH A . H 6 HOH 427 1332 1332 HOH HOH A . H 6 HOH 428 1333 1333 HOH HOH A . H 6 HOH 429 1334 1334 HOH HOH A . H 6 HOH 430 1335 1335 HOH HOH A . H 6 HOH 431 1336 1336 HOH HOH A . H 6 HOH 432 1337 1337 HOH HOH A . H 6 HOH 433 1338 1338 HOH HOH A . H 6 HOH 434 1339 1339 HOH HOH A . H 6 HOH 435 1340 1340 HOH HOH A . H 6 HOH 436 1341 1341 HOH HOH A . H 6 HOH 437 1342 1342 HOH HOH A . H 6 HOH 438 1343 1343 HOH HOH A . H 6 HOH 439 1344 1344 HOH HOH A . H 6 HOH 440 1345 1345 HOH HOH A . H 6 HOH 441 1346 1346 HOH HOH A . H 6 HOH 442 1347 1347 HOH HOH A . H 6 HOH 443 1348 1348 HOH HOH A . H 6 HOH 444 1349 1349 HOH HOH A . H 6 HOH 445 1350 1350 HOH HOH A . H 6 HOH 446 1351 1351 HOH HOH A . H 6 HOH 447 1352 1352 HOH HOH A . H 6 HOH 448 1353 1353 HOH HOH A . H 6 HOH 449 1354 1354 HOH HOH A . H 6 HOH 450 1355 1355 HOH HOH A . H 6 HOH 451 1356 1356 HOH HOH A . H 6 HOH 452 1357 1357 HOH HOH A . H 6 HOH 453 1358 1358 HOH HOH A . H 6 HOH 454 1359 1359 HOH HOH A . H 6 HOH 455 1360 1360 HOH HOH A . H 6 HOH 456 1361 1361 HOH HOH A . H 6 HOH 457 1362 1362 HOH HOH A . H 6 HOH 458 1363 1363 HOH HOH A . H 6 HOH 459 1364 1364 HOH HOH A . H 6 HOH 460 1365 1365 HOH HOH A . H 6 HOH 461 1366 1366 HOH HOH A . H 6 HOH 462 1367 1367 HOH HOH A . H 6 HOH 463 1368 1368 HOH HOH A . H 6 HOH 464 1369 1369 HOH HOH A . H 6 HOH 465 1370 1370 HOH HOH A . H 6 HOH 466 1371 1371 HOH HOH A . H 6 HOH 467 1372 1372 HOH HOH A . H 6 HOH 468 1373 1373 HOH HOH A . H 6 HOH 469 1374 1374 HOH HOH A . H 6 HOH 470 1375 1375 HOH HOH A . H 6 HOH 471 1376 1376 HOH HOH A . H 6 HOH 472 1377 1377 HOH HOH A . H 6 HOH 473 1378 1378 HOH HOH A . H 6 HOH 474 1379 1379 HOH HOH A . H 6 HOH 475 1380 1380 HOH HOH A . H 6 HOH 476 1381 1381 HOH HOH A . H 6 HOH 477 1382 1382 HOH HOH A . H 6 HOH 478 1383 1383 HOH HOH A . H 6 HOH 479 1384 1384 HOH HOH A . H 6 HOH 480 1385 1385 HOH HOH A . H 6 HOH 481 1386 1386 HOH HOH A . H 6 HOH 482 1387 1387 HOH HOH A . H 6 HOH 483 1388 1388 HOH HOH A . H 6 HOH 484 1389 1389 HOH HOH A . H 6 HOH 485 1390 1390 HOH HOH A . H 6 HOH 486 1391 1391 HOH HOH A . H 6 HOH 487 1392 1392 HOH HOH A . H 6 HOH 488 1393 1393 HOH HOH A . H 6 HOH 489 1394 1394 HOH HOH A . H 6 HOH 490 1395 1395 HOH HOH A . H 6 HOH 491 1396 1396 HOH HOH A . H 6 HOH 492 1397 1397 HOH HOH A . H 6 HOH 493 1398 1398 HOH HOH A . H 6 HOH 494 1399 1399 HOH HOH A . H 6 HOH 495 1400 1400 HOH HOH A . H 6 HOH 496 1401 1401 HOH HOH A . H 6 HOH 497 1402 1402 HOH HOH A . H 6 HOH 498 1403 1403 HOH HOH A . H 6 HOH 499 1404 1404 HOH HOH A . H 6 HOH 500 1405 1405 HOH HOH A . H 6 HOH 501 1406 1406 HOH HOH A . H 6 HOH 502 1407 1407 HOH HOH A . H 6 HOH 503 1408 1408 HOH HOH A . H 6 HOH 504 1409 1409 HOH HOH A . H 6 HOH 505 1410 1410 HOH HOH A . H 6 HOH 506 1411 1411 HOH HOH A . H 6 HOH 507 1412 1412 HOH HOH A . H 6 HOH 508 1413 1413 HOH HOH A . H 6 HOH 509 1414 1414 HOH HOH A . H 6 HOH 510 1415 1415 HOH HOH A . H 6 HOH 511 1416 1416 HOH HOH A . H 6 HOH 512 1417 1417 HOH HOH A . H 6 HOH 513 1418 1418 HOH HOH A . H 6 HOH 514 1419 1419 HOH HOH A . H 6 HOH 515 1420 1420 HOH HOH A . H 6 HOH 516 1421 1421 HOH HOH A . H 6 HOH 517 1422 1422 HOH HOH A . H 6 HOH 518 1423 1423 HOH HOH A . H 6 HOH 519 1424 1424 HOH HOH A . H 6 HOH 520 1425 1425 HOH HOH A . H 6 HOH 521 1426 1426 HOH HOH A . H 6 HOH 522 1427 1427 HOH HOH A . H 6 HOH 523 1428 1428 HOH HOH A . H 6 HOH 524 1429 1429 HOH HOH A . H 6 HOH 525 1430 1430 HOH HOH A . H 6 HOH 526 1431 1431 HOH HOH A . H 6 HOH 527 1432 1432 HOH HOH A . H 6 HOH 528 1433 1433 HOH HOH A . H 6 HOH 529 1434 1434 HOH HOH A . H 6 HOH 530 1435 1435 HOH HOH A . H 6 HOH 531 1436 1436 HOH HOH A . H 6 HOH 532 1437 1437 HOH HOH A . H 6 HOH 533 1438 1438 HOH HOH A . H 6 HOH 534 1439 1439 HOH HOH A . H 6 HOH 535 1440 1440 HOH HOH A . H 6 HOH 536 1441 1441 HOH HOH A . H 6 HOH 537 1442 1442 HOH HOH A . H 6 HOH 538 1443 1443 HOH HOH A . H 6 HOH 539 1444 1444 HOH HOH A . H 6 HOH 540 1445 1445 HOH HOH A . H 6 HOH 541 1446 1446 HOH HOH A . H 6 HOH 542 1447 1447 HOH HOH A . H 6 HOH 543 1448 1448 HOH HOH A . H 6 HOH 544 1449 1449 HOH HOH A . H 6 HOH 545 1450 1450 HOH HOH A . H 6 HOH 546 1451 1451 HOH HOH A . H 6 HOH 547 1452 1452 HOH HOH A . H 6 HOH 548 1453 1453 HOH HOH A . H 6 HOH 549 1454 1454 HOH HOH A . H 6 HOH 550 1455 1455 HOH HOH A . H 6 HOH 551 1456 1456 HOH HOH A . H 6 HOH 552 1457 1457 HOH HOH A . H 6 HOH 553 1458 1458 HOH HOH A . H 6 HOH 554 1459 1459 HOH HOH A . H 6 HOH 555 1460 1460 HOH HOH A . H 6 HOH 556 1461 1461 HOH HOH A . H 6 HOH 557 1462 1462 HOH HOH A . H 6 HOH 558 1463 1463 HOH HOH A . H 6 HOH 559 1464 1464 HOH HOH A . H 6 HOH 560 1465 1465 HOH HOH A . H 6 HOH 561 1466 1466 HOH HOH A . H 6 HOH 562 1467 1467 HOH HOH A . H 6 HOH 563 1468 1468 HOH HOH A . H 6 HOH 564 1469 1469 HOH HOH A . H 6 HOH 565 1470 1470 HOH HOH A . H 6 HOH 566 1471 1471 HOH HOH A . H 6 HOH 567 1472 1472 HOH HOH A . H 6 HOH 568 1473 1473 HOH HOH A . H 6 HOH 569 1474 1474 HOH HOH A . H 6 HOH 570 1475 1475 HOH HOH A . H 6 HOH 571 1476 1476 HOH HOH A . H 6 HOH 572 1477 1477 HOH HOH A . H 6 HOH 573 1478 1478 HOH HOH A . H 6 HOH 574 1479 1479 HOH HOH A . H 6 HOH 575 1480 1480 HOH HOH A . H 6 HOH 576 1481 1481 HOH HOH A . H 6 HOH 577 1482 1482 HOH HOH A . H 6 HOH 578 1483 1483 HOH HOH A . H 6 HOH 579 1484 1484 HOH HOH A . H 6 HOH 580 1485 1485 HOH HOH A . H 6 HOH 581 1486 1486 HOH HOH A . H 6 HOH 582 1487 1487 HOH HOH A . H 6 HOH 583 1488 1488 HOH HOH A . H 6 HOH 584 1489 1489 HOH HOH A . H 6 HOH 585 1490 1490 HOH HOH A . H 6 HOH 586 1491 1491 HOH HOH A . H 6 HOH 587 1492 1492 HOH HOH A . H 6 HOH 588 1493 1493 HOH HOH A . H 6 HOH 589 1494 1494 HOH HOH A . H 6 HOH 590 1495 1495 HOH HOH A . H 6 HOH 591 1496 1496 HOH HOH A . H 6 HOH 592 1497 1497 HOH HOH A . H 6 HOH 593 1498 1498 HOH HOH A . H 6 HOH 594 1499 1499 HOH HOH A . H 6 HOH 595 1500 1500 HOH HOH A . H 6 HOH 596 1501 1501 HOH HOH A . H 6 HOH 597 1502 1502 HOH HOH A . H 6 HOH 598 1503 1503 HOH HOH A . H 6 HOH 599 1504 1504 HOH HOH A . H 6 HOH 600 1505 1505 HOH HOH A . H 6 HOH 601 1506 1506 HOH HOH A . H 6 HOH 602 1507 1507 HOH HOH A . H 6 HOH 603 1508 1508 HOH HOH A . H 6 HOH 604 1509 1509 HOH HOH A . H 6 HOH 605 1510 1510 HOH HOH A . H 6 HOH 606 1511 1511 HOH HOH A . H 6 HOH 607 1512 1512 HOH HOH A . H 6 HOH 608 1513 1513 HOH HOH A . H 6 HOH 609 1514 1514 HOH HOH A . H 6 HOH 610 1515 1515 HOH HOH A . H 6 HOH 611 1516 1516 HOH HOH A . H 6 HOH 612 1517 1517 HOH HOH A . H 6 HOH 613 1518 1518 HOH HOH A . H 6 HOH 614 1519 1519 HOH HOH A . H 6 HOH 615 1520 1520 HOH HOH A . H 6 HOH 616 1521 1521 HOH HOH A . H 6 HOH 617 1522 1522 HOH HOH A . H 6 HOH 618 1523 1523 HOH HOH A . H 6 HOH 619 1524 1524 HOH HOH A . H 6 HOH 620 1525 1525 HOH HOH A . H 6 HOH 621 1526 1526 HOH HOH A . H 6 HOH 622 1527 1527 HOH HOH A . H 6 HOH 623 1528 1528 HOH HOH A . H 6 HOH 624 1529 1529 HOH HOH A . H 6 HOH 625 1530 1530 HOH HOH A . H 6 HOH 626 1531 1531 HOH HOH A . H 6 HOH 627 1532 1532 HOH HOH A . H 6 HOH 628 1533 1533 HOH HOH A . H 6 HOH 629 1534 1534 HOH HOH A . H 6 HOH 630 1535 1535 HOH HOH A . H 6 HOH 631 1536 1536 HOH HOH A . H 6 HOH 632 1537 1537 HOH HOH A . H 6 HOH 633 1538 1538 HOH HOH A . H 6 HOH 634 1539 1539 HOH HOH A . H 6 HOH 635 1540 1540 HOH HOH A . H 6 HOH 636 1541 1541 HOH HOH A . H 6 HOH 637 1542 1542 HOH HOH A . H 6 HOH 638 1543 1543 HOH HOH A . H 6 HOH 639 1544 1544 HOH HOH A . H 6 HOH 640 1545 1545 HOH HOH A . H 6 HOH 641 1546 1546 HOH HOH A . H 6 HOH 642 1547 1547 HOH HOH A . H 6 HOH 643 1548 1548 HOH HOH A . H 6 HOH 644 1549 1549 HOH HOH A . H 6 HOH 645 1550 1550 HOH HOH A . H 6 HOH 646 1551 1551 HOH HOH A . H 6 HOH 647 1552 1552 HOH HOH A . H 6 HOH 648 1553 1553 HOH HOH A . H 6 HOH 649 1554 1554 HOH HOH A . H 6 HOH 650 1555 1555 HOH HOH A . H 6 HOH 651 1556 1556 HOH HOH A . H 6 HOH 652 1557 1557 HOH HOH A . H 6 HOH 653 1558 1558 HOH HOH A . H 6 HOH 654 1559 1559 HOH HOH A . H 6 HOH 655 1560 1560 HOH HOH A . H 6 HOH 656 1561 1561 HOH HOH A . H 6 HOH 657 1562 1562 HOH HOH A . H 6 HOH 658 1563 1563 HOH HOH A . H 6 HOH 659 1564 1564 HOH HOH A . H 6 HOH 660 1565 1565 HOH HOH A . H 6 HOH 661 1566 1566 HOH HOH A . H 6 HOH 662 1567 1567 HOH HOH A . H 6 HOH 663 1568 1568 HOH HOH A . H 6 HOH 664 1569 1569 HOH HOH A . H 6 HOH 665 1570 1570 HOH HOH A . H 6 HOH 666 1571 1571 HOH HOH A . H 6 HOH 667 1572 1572 HOH HOH A . H 6 HOH 668 1573 1573 HOH HOH A . H 6 HOH 669 1574 1574 HOH HOH A . H 6 HOH 670 1575 1575 HOH HOH A . H 6 HOH 671 1576 1576 HOH HOH A . H 6 HOH 672 1577 1577 HOH HOH A . H 6 HOH 673 1578 1578 HOH HOH A . H 6 HOH 674 1579 1579 HOH HOH A . H 6 HOH 675 1580 1580 HOH HOH A . H 6 HOH 676 1581 1581 HOH HOH A . H 6 HOH 677 1582 1582 HOH HOH A . H 6 HOH 678 1583 1583 HOH HOH A . H 6 HOH 679 1584 1584 HOH HOH A . H 6 HOH 680 1585 1585 HOH HOH A . H 6 HOH 681 1586 1586 HOH HOH A . H 6 HOH 682 1587 1587 HOH HOH A . H 6 HOH 683 1588 1588 HOH HOH A . H 6 HOH 684 1589 1589 HOH HOH A . H 6 HOH 685 1590 1590 HOH HOH A . H 6 HOH 686 1591 1591 HOH HOH A . H 6 HOH 687 1592 1592 HOH HOH A . H 6 HOH 688 1593 1593 HOH HOH A . H 6 HOH 689 1594 1594 HOH HOH A . H 6 HOH 690 1595 1595 HOH HOH A . H 6 HOH 691 1596 1596 HOH HOH A . H 6 HOH 692 1597 1597 HOH HOH A . H 6 HOH 693 1598 1598 HOH HOH A . H 6 HOH 694 1599 1599 HOH HOH A . H 6 HOH 695 1600 1600 HOH HOH A . H 6 HOH 696 1601 1601 HOH HOH A . H 6 HOH 697 1602 1602 HOH HOH A . H 6 HOH 698 1603 1603 HOH HOH A . H 6 HOH 699 1604 1604 HOH HOH A . H 6 HOH 700 1605 1605 HOH HOH A . H 6 HOH 701 1606 1606 HOH HOH A . H 6 HOH 702 1607 1607 HOH HOH A . H 6 HOH 703 1608 1608 HOH HOH A . H 6 HOH 704 1609 1609 HOH HOH A . H 6 HOH 705 1610 1610 HOH HOH A . H 6 HOH 706 1611 1611 HOH HOH A . H 6 HOH 707 1612 1612 HOH HOH A . H 6 HOH 708 1613 1613 HOH HOH A . H 6 HOH 709 1614 1614 HOH HOH A . H 6 HOH 710 1615 1615 HOH HOH A . # loop_ _pdbx_struct_mod_residue.id _pdbx_struct_mod_residue.label_asym_id _pdbx_struct_mod_residue.label_comp_id _pdbx_struct_mod_residue.label_seq_id _pdbx_struct_mod_residue.auth_asym_id _pdbx_struct_mod_residue.auth_comp_id _pdbx_struct_mod_residue.auth_seq_id _pdbx_struct_mod_residue.PDB_ins_code _pdbx_struct_mod_residue.parent_comp_id _pdbx_struct_mod_residue.details 1 A ASN 122 A ASN 122 ? ASN 'GLYCOSYLATION SITE' 2 A ASN 249 A ASN 249 ? ASN 'GLYCOSYLATION SITE' 3 A SEP 92 A SEP 92 ? SER PHOSPHOSERINE # _pdbx_struct_assembly.id 1 _pdbx_struct_assembly.details author_and_software_defined_assembly _pdbx_struct_assembly.method_details PISA,PQS _pdbx_struct_assembly.oligomeric_details dimeric _pdbx_struct_assembly.oligomeric_count 2 # _pdbx_struct_assembly_gen.assembly_id 1 _pdbx_struct_assembly_gen.oper_expression 1,2 _pdbx_struct_assembly_gen.asym_id_list A,B,C,D,E,F,G,H # loop_ _pdbx_struct_assembly_prop.biol_id _pdbx_struct_assembly_prop.type _pdbx_struct_assembly_prop.value _pdbx_struct_assembly_prop.details 1 'ABSA (A^2)' 9830 ? 1 MORE -184 ? 1 'SSA (A^2)' 31550 ? # loop_ _pdbx_struct_oper_list.id _pdbx_struct_oper_list.type _pdbx_struct_oper_list.name _pdbx_struct_oper_list.symmetry_operation _pdbx_struct_oper_list.matrix[1][1] _pdbx_struct_oper_list.matrix[1][2] _pdbx_struct_oper_list.matrix[1][3] _pdbx_struct_oper_list.vector[1] _pdbx_struct_oper_list.matrix[2][1] _pdbx_struct_oper_list.matrix[2][2] _pdbx_struct_oper_list.matrix[2][3] _pdbx_struct_oper_list.vector[2] _pdbx_struct_oper_list.matrix[3][1] _pdbx_struct_oper_list.matrix[3][2] _pdbx_struct_oper_list.matrix[3][3] _pdbx_struct_oper_list.vector[3] 1 'identity operation' 1_555 x,y,z 1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 2 'crystal symmetry operation' 3_655 -x+1,y,-z+1/2 -1.0000000000 0.0000000000 0.0000000000 89.0220000000 0.0000000000 1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 53.2970000000 # loop_ _pdbx_struct_conn_angle.id _pdbx_struct_conn_angle.ptnr1_label_atom_id _pdbx_struct_conn_angle.ptnr1_label_alt_id _pdbx_struct_conn_angle.ptnr1_label_asym_id _pdbx_struct_conn_angle.ptnr1_label_comp_id _pdbx_struct_conn_angle.ptnr1_label_seq_id _pdbx_struct_conn_angle.ptnr1_auth_atom_id _pdbx_struct_conn_angle.ptnr1_auth_asym_id _pdbx_struct_conn_angle.ptnr1_auth_comp_id _pdbx_struct_conn_angle.ptnr1_auth_seq_id _pdbx_struct_conn_angle.ptnr1_PDB_ins_code _pdbx_struct_conn_angle.ptnr1_symmetry _pdbx_struct_conn_angle.ptnr2_label_atom_id _pdbx_struct_conn_angle.ptnr2_label_alt_id _pdbx_struct_conn_angle.ptnr2_label_asym_id _pdbx_struct_conn_angle.ptnr2_label_comp_id _pdbx_struct_conn_angle.ptnr2_label_seq_id _pdbx_struct_conn_angle.ptnr2_auth_atom_id _pdbx_struct_conn_angle.ptnr2_auth_asym_id _pdbx_struct_conn_angle.ptnr2_auth_comp_id _pdbx_struct_conn_angle.ptnr2_auth_seq_id _pdbx_struct_conn_angle.ptnr2_PDB_ins_code _pdbx_struct_conn_angle.ptnr2_symmetry _pdbx_struct_conn_angle.ptnr3_label_atom_id _pdbx_struct_conn_angle.ptnr3_label_alt_id _pdbx_struct_conn_angle.ptnr3_label_asym_id _pdbx_struct_conn_angle.ptnr3_label_comp_id _pdbx_struct_conn_angle.ptnr3_label_seq_id _pdbx_struct_conn_angle.ptnr3_auth_atom_id _pdbx_struct_conn_angle.ptnr3_auth_asym_id _pdbx_struct_conn_angle.ptnr3_auth_comp_id _pdbx_struct_conn_angle.ptnr3_auth_seq_id _pdbx_struct_conn_angle.ptnr3_PDB_ins_code _pdbx_struct_conn_angle.ptnr3_symmetry _pdbx_struct_conn_angle.value _pdbx_struct_conn_angle.value_esd 1 OD1 ? A ASP 42 ? A ASP 42 ? 1_555 ZN ? E ZN . ? A ZN 902 ? 1_555 OG ? A SEP 92 ? A SEP 92 ? 1_555 122.2 ? 2 OD1 ? A ASP 42 ? A ASP 42 ? 1_555 ZN ? E ZN . ? A ZN 902 ? 1_555 O3P ? A SEP 92 ? A SEP 92 ? 1_555 98.0 ? 3 OG ? A SEP 92 ? A SEP 92 ? 1_555 ZN ? E ZN . ? A ZN 902 ? 1_555 O3P ? A SEP 92 ? A SEP 92 ? 1_555 72.1 ? 4 OD1 ? A ASP 42 ? A ASP 42 ? 1_555 ZN ? E ZN . ? A ZN 902 ? 1_555 OD2 ? A ASP 357 ? A ASP 357 ? 1_555 95.7 ? 5 OG ? A SEP 92 ? A SEP 92 ? 1_555 ZN ? E ZN . ? A ZN 902 ? 1_555 OD2 ? A ASP 357 ? A ASP 357 ? 1_555 86.2 ? 6 O3P ? A SEP 92 ? A SEP 92 ? 1_555 ZN ? E ZN . ? A ZN 902 ? 1_555 OD2 ? A ASP 357 ? A ASP 357 ? 1_555 158.2 ? 7 OD1 ? A ASP 42 ? A ASP 42 ? 1_555 ZN ? E ZN . ? A ZN 902 ? 1_555 NE2 ? A HIS 358 ? A HIS 358 ? 1_555 114.3 ? 8 OG ? A SEP 92 ? A SEP 92 ? 1_555 ZN ? E ZN . ? A ZN 902 ? 1_555 NE2 ? A HIS 358 ? A HIS 358 ? 1_555 123.0 ? 9 O3P ? A SEP 92 ? A SEP 92 ? 1_555 ZN ? E ZN . ? A ZN 902 ? 1_555 NE2 ? A HIS 358 ? A HIS 358 ? 1_555 94.0 ? 10 OD2 ? A ASP 357 ? A ASP 357 ? 1_555 ZN ? E ZN . ? A ZN 902 ? 1_555 NE2 ? A HIS 358 ? A HIS 358 ? 1_555 95.7 ? 11 OD2 ? A ASP 42 ? A ASP 42 ? 1_555 MG ? F MG . ? A MG 903 ? 1_555 OG ? A SER 155 ? A SER 155 ? 1_555 87.4 ? 12 OD2 ? A ASP 42 ? A ASP 42 ? 1_555 MG ? F MG . ? A MG 903 ? 1_555 OE2 ? A GLU 311 ? A GLU 311 ? 1_555 95.8 ? 13 OG ? A SER 155 ? A SER 155 ? 1_555 MG ? F MG . ? A MG 903 ? 1_555 OE2 ? A GLU 311 ? A GLU 311 ? 1_555 87.4 ? 14 OD2 ? A ASP 42 ? A ASP 42 ? 1_555 MG ? F MG . ? A MG 903 ? 1_555 O ? H HOH . ? A HOH 937 ? 1_555 179.3 ? 15 OG ? A SER 155 ? A SER 155 ? 1_555 MG ? F MG . ? A MG 903 ? 1_555 O ? H HOH . ? A HOH 937 ? 1_555 93.2 ? 16 OE2 ? A GLU 311 ? A GLU 311 ? 1_555 MG ? F MG . ? A MG 903 ? 1_555 O ? H HOH . ? A HOH 937 ? 1_555 84.0 ? 17 OD2 ? A ASP 42 ? A ASP 42 ? 1_555 MG ? F MG . ? A MG 903 ? 1_555 O ? H HOH . ? A HOH 927 ? 1_555 96.2 ? 18 OG ? A SER 155 ? A SER 155 ? 1_555 MG ? F MG . ? A MG 903 ? 1_555 O ? H HOH . ? A HOH 927 ? 1_555 85.2 ? 19 OE2 ? A GLU 311 ? A GLU 311 ? 1_555 MG ? F MG . ? A MG 903 ? 1_555 O ? H HOH . ? A HOH 927 ? 1_555 165.6 ? 20 O ? H HOH . ? A HOH 937 ? 1_555 MG ? F MG . ? A MG 903 ? 1_555 O ? H HOH . ? A HOH 927 ? 1_555 84.1 ? 21 OD2 ? A ASP 42 ? A ASP 42 ? 1_555 MG ? F MG . ? A MG 903 ? 1_555 O ? H HOH . ? A HOH 910 ? 1_555 85.9 ? 22 OG ? A SER 155 ? A SER 155 ? 1_555 MG ? F MG . ? A MG 903 ? 1_555 O ? H HOH . ? A HOH 910 ? 1_555 173.3 ? 23 OE2 ? A GLU 311 ? A GLU 311 ? 1_555 MG ? F MG . ? A MG 903 ? 1_555 O ? H HOH . ? A HOH 910 ? 1_555 92.6 ? 24 O ? H HOH . ? A HOH 937 ? 1_555 MG ? F MG . ? A MG 903 ? 1_555 O ? H HOH . ? A HOH 910 ? 1_555 93.5 ? 25 O ? H HOH . ? A HOH 927 ? 1_555 MG ? F MG . ? A MG 903 ? 1_555 O ? H HOH . ? A HOH 910 ? 1_555 96.2 ? 26 O3P ? A SEP 92 ? A SEP 92 ? 1_555 ZN ? D ZN . ? A ZN 901 ? 1_555 OD1 ? A ASP 316 ? A ASP 316 ? 1_555 82.4 ? 27 O3P ? A SEP 92 ? A SEP 92 ? 1_555 ZN ? D ZN . ? A ZN 901 ? 1_555 OD2 ? A ASP 316 ? A ASP 316 ? 1_555 81.5 ? 28 OD1 ? A ASP 316 ? A ASP 316 ? 1_555 ZN ? D ZN . ? A ZN 901 ? 1_555 OD2 ? A ASP 316 ? A ASP 316 ? 1_555 61.2 ? 29 O3P ? A SEP 92 ? A SEP 92 ? 1_555 ZN ? D ZN . ? A ZN 901 ? 1_555 NE2 ? A HIS 320 ? A HIS 320 ? 1_555 171.5 ? 30 OD1 ? A ASP 316 ? A ASP 316 ? 1_555 ZN ? D ZN . ? A ZN 901 ? 1_555 NE2 ? A HIS 320 ? A HIS 320 ? 1_555 90.1 ? 31 OD2 ? A ASP 316 ? A ASP 316 ? 1_555 ZN ? D ZN . ? A ZN 901 ? 1_555 NE2 ? A HIS 320 ? A HIS 320 ? 1_555 91.5 ? 32 O3P ? A SEP 92 ? A SEP 92 ? 1_555 ZN ? D ZN . ? A ZN 901 ? 1_555 NE2 ? A HIS 432 ? A HIS 432 ? 1_555 86.9 ? 33 OD1 ? A ASP 316 ? A ASP 316 ? 1_555 ZN ? D ZN . ? A ZN 901 ? 1_555 NE2 ? A HIS 432 ? A HIS 432 ? 1_555 154.5 ? 34 OD2 ? A ASP 316 ? A ASP 316 ? 1_555 ZN ? D ZN . ? A ZN 901 ? 1_555 NE2 ? A HIS 432 ? A HIS 432 ? 1_555 94.5 ? 35 NE2 ? A HIS 320 ? A HIS 320 ? 1_555 ZN ? D ZN . ? A ZN 901 ? 1_555 NE2 ? A HIS 432 ? A HIS 432 ? 1_555 98.4 ? 36 OE1 ? A GLU 216 ? A GLU 216 ? 1_555 CA ? G CA . ? A CA 904 ? 1_555 OE2 ? A GLU 216 ? A GLU 216 ? 1_555 55.9 ? 37 OE1 ? A GLU 216 ? A GLU 216 ? 1_555 CA ? G CA . ? A CA 904 ? 1_555 O ? A PHE 269 ? A PHE 269 ? 1_555 81.1 ? 38 OE2 ? A GLU 216 ? A GLU 216 ? 1_555 CA ? G CA . ? A CA 904 ? 1_555 O ? A PHE 269 ? A PHE 269 ? 1_555 136.9 ? 39 OE1 ? A GLU 216 ? A GLU 216 ? 1_555 CA ? G CA . ? A CA 904 ? 1_555 OE2 ? A GLU 270 ? A GLU 270 ? 1_555 104.2 ? 40 OE2 ? A GLU 216 ? A GLU 216 ? 1_555 CA ? G CA . ? A CA 904 ? 1_555 OE2 ? A GLU 270 ? A GLU 270 ? 1_555 106.8 ? 41 O ? A PHE 269 ? A PHE 269 ? 1_555 CA ? G CA . ? A CA 904 ? 1_555 OE2 ? A GLU 270 ? A GLU 270 ? 1_555 85.2 ? 42 OE1 ? A GLU 216 ? A GLU 216 ? 1_555 CA ? G CA . ? A CA 904 ? 1_555 OD1 ? A ASP 285 ? A ASP 285 ? 1_555 156.2 ? 43 OE2 ? A GLU 216 ? A GLU 216 ? 1_555 CA ? G CA . ? A CA 904 ? 1_555 OD1 ? A ASP 285 ? A ASP 285 ? 1_555 144.9 ? 44 O ? A PHE 269 ? A PHE 269 ? 1_555 CA ? G CA . ? A CA 904 ? 1_555 OD1 ? A ASP 285 ? A ASP 285 ? 1_555 76.6 ? 45 OE2 ? A GLU 270 ? A GLU 270 ? 1_555 CA ? G CA . ? A CA 904 ? 1_555 OD1 ? A ASP 285 ? A ASP 285 ? 1_555 82.2 ? 46 OE1 ? A GLU 216 ? A GLU 216 ? 1_555 CA ? G CA . ? A CA 904 ? 1_555 OD2 ? A ASP 285 ? A ASP 285 ? 1_555 146.6 ? 47 OE2 ? A GLU 216 ? A GLU 216 ? 1_555 CA ? G CA . ? A CA 904 ? 1_555 OD2 ? A ASP 285 ? A ASP 285 ? 1_555 93.2 ? 48 O ? A PHE 269 ? A PHE 269 ? 1_555 CA ? G CA . ? A CA 904 ? 1_555 OD2 ? A ASP 285 ? A ASP 285 ? 1_555 127.3 ? 49 OE2 ? A GLU 270 ? A GLU 270 ? 1_555 CA ? G CA . ? A CA 904 ? 1_555 OD2 ? A ASP 285 ? A ASP 285 ? 1_555 96.4 ? 50 OD1 ? A ASP 285 ? A ASP 285 ? 1_555 CA ? G CA . ? A CA 904 ? 1_555 OD2 ? A ASP 285 ? A ASP 285 ? 1_555 51.8 ? 51 OE1 ? A GLU 216 ? A GLU 216 ? 1_555 CA ? G CA . ? A CA 904 ? 1_555 O ? H HOH . ? A HOH 995 ? 1_555 83.3 ? 52 OE2 ? A GLU 216 ? A GLU 216 ? 1_555 CA ? G CA . ? A CA 904 ? 1_555 O ? H HOH . ? A HOH 995 ? 1_555 86.2 ? 53 O ? A PHE 269 ? A PHE 269 ? 1_555 CA ? G CA . ? A CA 904 ? 1_555 O ? H HOH . ? A HOH 995 ? 1_555 85.7 ? 54 OE2 ? A GLU 270 ? A GLU 270 ? 1_555 CA ? G CA . ? A CA 904 ? 1_555 O ? H HOH . ? A HOH 995 ? 1_555 167.1 ? 55 OD1 ? A ASP 285 ? A ASP 285 ? 1_555 CA ? G CA . ? A CA 904 ? 1_555 O ? H HOH . ? A HOH 995 ? 1_555 86.8 ? 56 OD2 ? A ASP 285 ? A ASP 285 ? 1_555 CA ? G CA . ? A CA 904 ? 1_555 O ? H HOH . ? A HOH 995 ? 1_555 82.1 ? # loop_ _pdbx_audit_revision_history.ordinal _pdbx_audit_revision_history.data_content_type _pdbx_audit_revision_history.major_revision _pdbx_audit_revision_history.minor_revision _pdbx_audit_revision_history.revision_date 1 'Structure model' 1 0 2005-06-28 2 'Structure model' 1 1 2008-04-30 3 'Structure model' 1 2 2011-07-13 # _pdbx_audit_revision_details.ordinal 1 _pdbx_audit_revision_details.revision_ordinal 1 _pdbx_audit_revision_details.data_content_type 'Structure model' _pdbx_audit_revision_details.provider repository _pdbx_audit_revision_details.type 'Initial release' _pdbx_audit_revision_details.description ? # loop_ _pdbx_audit_revision_group.ordinal _pdbx_audit_revision_group.revision_ordinal _pdbx_audit_revision_group.data_content_type _pdbx_audit_revision_group.group 1 2 'Structure model' 'Version format compliance' 2 3 'Structure model' 'Derived calculations' 3 3 'Structure model' 'Version format compliance' # loop_ _software.name _software.classification _software.version _software.citation_id _software.pdbx_ordinal REFMAC refinement 5.2.0003 ? 1 DENZO 'data reduction' . ? 2 SCALEPACK 'data scaling' . ? 3 FFT phasing . ? 4 # loop_ _pdbx_validate_close_contact.id _pdbx_validate_close_contact.PDB_model_num _pdbx_validate_close_contact.auth_atom_id_1 _pdbx_validate_close_contact.auth_asym_id_1 _pdbx_validate_close_contact.auth_comp_id_1 _pdbx_validate_close_contact.auth_seq_id_1 _pdbx_validate_close_contact.PDB_ins_code_1 _pdbx_validate_close_contact.label_alt_id_1 _pdbx_validate_close_contact.auth_atom_id_2 _pdbx_validate_close_contact.auth_asym_id_2 _pdbx_validate_close_contact.auth_comp_id_2 _pdbx_validate_close_contact.auth_seq_id_2 _pdbx_validate_close_contact.PDB_ins_code_2 _pdbx_validate_close_contact.label_alt_id_2 _pdbx_validate_close_contact.dist 1 1 O A HOH 1100 ? ? O A HOH 1463 ? ? 2.03 2 1 OG A SER 261 ? ? O A HOH 1504 ? ? 2.11 3 1 O A HOH 1151 ? ? O A HOH 1200 ? ? 2.13 # loop_ _pdbx_validate_symm_contact.id _pdbx_validate_symm_contact.PDB_model_num _pdbx_validate_symm_contact.auth_atom_id_1 _pdbx_validate_symm_contact.auth_asym_id_1 _pdbx_validate_symm_contact.auth_comp_id_1 _pdbx_validate_symm_contact.auth_seq_id_1 _pdbx_validate_symm_contact.PDB_ins_code_1 _pdbx_validate_symm_contact.label_alt_id_1 _pdbx_validate_symm_contact.site_symmetry_1 _pdbx_validate_symm_contact.auth_atom_id_2 _pdbx_validate_symm_contact.auth_asym_id_2 _pdbx_validate_symm_contact.auth_comp_id_2 _pdbx_validate_symm_contact.auth_seq_id_2 _pdbx_validate_symm_contact.PDB_ins_code_2 _pdbx_validate_symm_contact.label_alt_id_2 _pdbx_validate_symm_contact.site_symmetry_2 _pdbx_validate_symm_contact.dist 1 1 O A HOH 1026 ? ? 1_555 O A HOH 1363 ? ? 3_655 2.09 2 1 O A HOH 1072 ? ? 1_555 O A HOH 1378 ? ? 8_555 2.13 3 1 O A HOH 1363 ? ? 1_555 O A HOH 1363 ? ? 3_655 2.14 4 1 O A HOH 1065 ? ? 1_555 O A HOH 1378 ? ? 3_655 2.17 # loop_ _pdbx_validate_rmsd_angle.id _pdbx_validate_rmsd_angle.PDB_model_num _pdbx_validate_rmsd_angle.auth_atom_id_1 _pdbx_validate_rmsd_angle.auth_asym_id_1 _pdbx_validate_rmsd_angle.auth_comp_id_1 _pdbx_validate_rmsd_angle.auth_seq_id_1 _pdbx_validate_rmsd_angle.PDB_ins_code_1 _pdbx_validate_rmsd_angle.label_alt_id_1 _pdbx_validate_rmsd_angle.auth_atom_id_2 _pdbx_validate_rmsd_angle.auth_asym_id_2 _pdbx_validate_rmsd_angle.auth_comp_id_2 _pdbx_validate_rmsd_angle.auth_seq_id_2 _pdbx_validate_rmsd_angle.PDB_ins_code_2 _pdbx_validate_rmsd_angle.label_alt_id_2 _pdbx_validate_rmsd_angle.auth_atom_id_3 _pdbx_validate_rmsd_angle.auth_asym_id_3 _pdbx_validate_rmsd_angle.auth_comp_id_3 _pdbx_validate_rmsd_angle.auth_seq_id_3 _pdbx_validate_rmsd_angle.PDB_ins_code_3 _pdbx_validate_rmsd_angle.label_alt_id_3 _pdbx_validate_rmsd_angle.angle_value _pdbx_validate_rmsd_angle.angle_target_value _pdbx_validate_rmsd_angle.angle_deviation _pdbx_validate_rmsd_angle.angle_standard_deviation _pdbx_validate_rmsd_angle.linker_flag 1 1 CB A ASP 220 ? ? CG A ASP 220 ? ? OD2 A ASP 220 ? ? 124.06 118.30 5.76 0.90 N 2 1 CB A ASP 259 ? ? CG A ASP 259 ? ? OD2 A ASP 259 ? ? 123.72 118.30 5.42 0.90 N 3 1 CB A ASP 316 ? ? CG A ASP 316 ? ? OD2 A ASP 316 ? ? 127.89 118.30 9.59 0.90 N 4 1 CB A ASP 349 ? ? CG A ASP 349 ? ? OD2 A ASP 349 ? ? 124.77 118.30 6.47 0.90 N # loop_ _pdbx_validate_torsion.id _pdbx_validate_torsion.PDB_model_num _pdbx_validate_torsion.auth_comp_id _pdbx_validate_torsion.auth_asym_id _pdbx_validate_torsion.auth_seq_id _pdbx_validate_torsion.PDB_ins_code _pdbx_validate_torsion.label_alt_id _pdbx_validate_torsion.phi _pdbx_validate_torsion.psi 1 1 LYS A 60 ? ? -71.05 -157.25 2 1 PHE A 107 ? ? -28.97 124.89 3 1 SER A 261 ? ? 81.56 -13.06 4 1 SER A 359 ? ? -107.33 -165.61 5 1 VAL A 361 ? ? -79.56 39.85 6 1 ASP A 403 ? ? 21.28 70.79 7 1 GLU A 469 ? ? 70.84 -142.46 8 1 ALA A 473 ? ? -89.24 43.65 # _pdbx_validate_peptide_omega.id 1 _pdbx_validate_peptide_omega.PDB_model_num 1 _pdbx_validate_peptide_omega.auth_comp_id_1 LEU _pdbx_validate_peptide_omega.auth_asym_id_1 A _pdbx_validate_peptide_omega.auth_seq_id_1 468 _pdbx_validate_peptide_omega.PDB_ins_code_1 ? _pdbx_validate_peptide_omega.label_alt_id_1 ? _pdbx_validate_peptide_omega.auth_comp_id_2 GLU _pdbx_validate_peptide_omega.auth_asym_id_2 A _pdbx_validate_peptide_omega.auth_seq_id_2 469 _pdbx_validate_peptide_omega.PDB_ins_code_2 ? _pdbx_validate_peptide_omega.label_alt_id_2 ? _pdbx_validate_peptide_omega.omega 148.96 # loop_ _pdbx_unobs_or_zero_occ_atoms.id _pdbx_unobs_or_zero_occ_atoms.PDB_model_num _pdbx_unobs_or_zero_occ_atoms.polymer_flag _pdbx_unobs_or_zero_occ_atoms.occupancy_flag _pdbx_unobs_or_zero_occ_atoms.auth_asym_id _pdbx_unobs_or_zero_occ_atoms.auth_comp_id _pdbx_unobs_or_zero_occ_atoms.auth_seq_id _pdbx_unobs_or_zero_occ_atoms.PDB_ins_code _pdbx_unobs_or_zero_occ_atoms.auth_atom_id _pdbx_unobs_or_zero_occ_atoms.label_alt_id _pdbx_unobs_or_zero_occ_atoms.label_asym_id _pdbx_unobs_or_zero_occ_atoms.label_comp_id _pdbx_unobs_or_zero_occ_atoms.label_seq_id _pdbx_unobs_or_zero_occ_atoms.label_atom_id 1 1 Y 1 A ILE 1 ? CG1 ? A ILE 1 CG1 2 1 Y 1 A ILE 1 ? CG2 ? A ILE 1 CG2 3 1 Y 1 A ILE 1 ? CD1 ? A ILE 1 CD1 4 1 Y 1 A ASP 61 ? CG ? A ASP 61 CG 5 1 Y 1 A ASP 61 ? OD1 ? A ASP 61 OD1 6 1 Y 1 A ASP 61 ? OD2 ? A ASP 61 OD2 7 1 Y 1 A GLU 469 ? CG ? A GLU 469 CG 8 1 Y 1 A GLU 469 ? CD ? A GLU 469 CD 9 1 Y 1 A GLU 469 ? OE1 ? A GLU 469 OE1 10 1 Y 1 A GLU 469 ? OE2 ? A GLU 469 OE2 # loop_ _pdbx_unobs_or_zero_occ_residues.id _pdbx_unobs_or_zero_occ_residues.PDB_model_num _pdbx_unobs_or_zero_occ_residues.polymer_flag _pdbx_unobs_or_zero_occ_residues.occupancy_flag _pdbx_unobs_or_zero_occ_residues.auth_asym_id _pdbx_unobs_or_zero_occ_residues.auth_comp_id _pdbx_unobs_or_zero_occ_residues.auth_seq_id _pdbx_unobs_or_zero_occ_residues.PDB_ins_code _pdbx_unobs_or_zero_occ_residues.label_asym_id _pdbx_unobs_or_zero_occ_residues.label_comp_id _pdbx_unobs_or_zero_occ_residues.label_seq_id 1 1 Y 1 A GLY 481 ? A GLY 481 2 1 Y 1 A THR 482 ? A THR 482 3 1 Y 1 A THR 483 ? A THR 483 4 1 Y 1 A ASP 484 ? A ASP 484 # loop_ _pdbx_entity_nonpoly.entity_id _pdbx_entity_nonpoly.name _pdbx_entity_nonpoly.comp_id 2 N-ACETYL-D-GLUCOSAMINE NAG 3 'ZINC ION' ZN 4 'MAGNESIUM ION' MG 5 'CALCIUM ION' CA 6 water HOH #