data_1XLV # _entry.id 1XLV # _audit_conform.dict_name mmcif_pdbx.dic _audit_conform.dict_version 5.286 _audit_conform.dict_location http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic # loop_ _database_2.database_id _database_2.database_code PDB 1XLV RCSB RCSB030493 WWPDB D_1000030493 # loop_ _pdbx_database_related.db_name _pdbx_database_related.db_id _pdbx_database_related.details _pdbx_database_related.content_type PDB 1POI . unspecified PDB 1POM . unspecified PDB 1POP . unspecified PDB 1POQ . unspecified PDB 1XLU . unspecified PDB 1XLW . unspecified # _pdbx_database_status.entry_id 1XLV _pdbx_database_status.status_code REL _pdbx_database_status.recvd_initial_deposition_date 2004-09-30 _pdbx_database_status.deposit_site RCSB _pdbx_database_status.process_site RCSB _pdbx_database_status.status_code_sf REL _pdbx_database_status.status_code_mr ? _pdbx_database_status.SG_entry N _pdbx_database_status.pdb_format_compatible Y _pdbx_database_status.status_code_cs ? _pdbx_database_status.methods_development_category ? # loop_ _audit_author.name _audit_author.pdbx_ordinal 'Nachon, F.' 1 'Asojo, O.A.' 2 'Borgstahl, G.E.O.' 3 'Masson, P.' 4 'Lockridge, O.' 5 # loop_ _citation.id _citation.title _citation.journal_abbrev _citation.journal_volume _citation.page_first _citation.page_last _citation.year _citation.journal_id_ASTM _citation.country _citation.journal_id_ISSN _citation.journal_id_CSD _citation.book_publisher _citation.pdbx_database_id_PubMed _citation.pdbx_database_id_DOI primary ;Role of Water in Aging of Human Butyrylcholinesterase Inhibited by Echothiophate: The Crystal Structure Suggests Two Alternative Mechanisms of Aging ; Biochemistry 44 1154 1162 2005 BICHAW US 0006-2960 0033 ? 15667209 10.1021/bi048238d 1 ;Engineering of a monomeric and low-glycosylated form of human butyrylcholinesterase: expression, purification, characterization and crystallization ; Eur.J.Biochem. 269 630 666 2002 EJBCAI IX 0014-2956 0262 ? ? ? 2 'Crystal structure of human butyrylcholinesterase and of its complexes with substrate and products' J.Biol.Chem. 278 41141 41147 2003 JBCHA3 US 0021-9258 0071 ? ? ? # loop_ _citation_author.citation_id _citation_author.name _citation_author.ordinal primary 'Nachon, F.' 1 primary 'Asojo, O.A.' 2 primary 'Borgstahl, G.E.O.' 3 primary 'Masson, P.' 4 primary 'Lockridge, O.' 5 1 'Nachon, F.' 6 1 'Nicolet, Y.' 7 1 'Viguie, N.' 8 1 'Masson, P.' 9 1 'Fontecilla-Camps, J.C.' 10 1 'Lockridge, O.' 11 2 'Nicolet, Y.' 12 2 'Lockridge, O.' 13 2 'Masson, P.' 14 2 'Fontecilla-Camps, J.C.' 15 2 'Nachon, F.' 16 # _cell.entry_id 1XLV _cell.length_a 154.587 _cell.length_b 154.587 _cell.length_c 126.706 _cell.angle_alpha 90.00 _cell.angle_beta 90.00 _cell.angle_gamma 90.00 _cell.Z_PDB 16 _cell.pdbx_unique_axis ? _cell.length_a_esd ? _cell.length_b_esd ? _cell.length_c_esd ? _cell.angle_alpha_esd ? _cell.angle_beta_esd ? _cell.angle_gamma_esd ? # _symmetry.entry_id 1XLV _symmetry.space_group_name_H-M 'I 4 2 2' _symmetry.cell_setting tetragonal _symmetry.pdbx_full_space_group_name_H-M ? _symmetry.Int_Tables_number 97 _symmetry.space_group_name_Hall ? # loop_ _entity.id _entity.type _entity.src_method _entity.pdbx_description _entity.formula_weight _entity.pdbx_number_of_molecules _entity.pdbx_ec _entity.pdbx_mutation _entity.pdbx_fragment _entity.details 1 polymer man BUTYRYLCHOLINESTERASE 59745.574 1 3.1.1.8 aged ? 'aged, Ser 198 covalently bound to EFS' 2 non-polymer man N-ACETYL-D-GLUCOSAMINE 221.208 8 ? ? ? ? 3 non-polymer man BETA-L-FUCOSE 164.156 1 ? ? ? ? 4 non-polymer syn 'SULFATE ION' 96.063 3 ? ? ? ? 5 non-polymer syn 'CHLORIDE ION' 35.453 3 ? ? ? ? 6 non-polymer syn 'ETHYL DIHYDROGEN PHOSPHATE' 126.048 1 ? ? ? ? 7 non-polymer syn GLYCEROL 92.094 4 ? ? ? ? 8 water nat water 18.015 220 ? ? ? ? # _entity_name_com.entity_id 1 _entity_name_com.name 'Acylcholine acylhydrolase; Choline esterase II; Butyrylcholine esterase; Pseudocholinesterase' # _entity_name_sys.entity_id 1 _entity_name_sys.name E.C.3.1.1.8 # _entity_poly.entity_id 1 _entity_poly.type 'polypeptide(L)' _entity_poly.nstd_linkage no _entity_poly.nstd_monomer yes _entity_poly.pdbx_seq_one_letter_code ;EDDIIIATKNGKVRGMQLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATKYANSC(CSS)QNIDQSFPGF HGSEMWNPNTDLSEDCLYLNVWIPAPKPKNATVLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLAL PGNPEAPGNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPGSHSLFTRAILQSGSFNAPWAVTSL YEARNRTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTPLSVNFGPTVDGDFLTDMPDILLELGQFKKTQ ILVGVNKDEGTAFLVYGAPGFSKDNNSIITRKEFQEGLKIFFPGVSEFGKESILFHYTDWVDDQRPENYREALGDVVGDY NFICPALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDQYTKAEEILSRSIVKRWANFAK YGNPQETQNQSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWTSFFPKV ; _entity_poly.pdbx_seq_one_letter_code_can ;EDDIIIATKNGKVRGMQLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATKYANSCCQNIDQSFPGFHGSE MWNPNTDLSEDCLYLNVWIPAPKPKNATVLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNP EAPGNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPGSHSLFTRAILQSGSFNAPWAVTSLYEAR NRTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTPLSVNFGPTVDGDFLTDMPDILLELGQFKKTQILVG VNKDEGTAFLVYGAPGFSKDNNSIITRKEFQEGLKIFFPGVSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFIC PALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDQYTKAEEILSRSIVKRWANFAKYGNP QETQNQSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWTSFFPKV ; _entity_poly.pdbx_strand_id A _entity_poly.pdbx_target_identifier ? # loop_ _entity_poly_seq.entity_id _entity_poly_seq.num _entity_poly_seq.mon_id _entity_poly_seq.hetero 1 1 GLU n 1 2 ASP n 1 3 ASP n 1 4 ILE n 1 5 ILE n 1 6 ILE n 1 7 ALA n 1 8 THR n 1 9 LYS n 1 10 ASN n 1 11 GLY n 1 12 LYS n 1 13 VAL n 1 14 ARG n 1 15 GLY n 1 16 MET n 1 17 GLN n 1 18 LEU n 1 19 THR n 1 20 VAL n 1 21 PHE n 1 22 GLY n 1 23 GLY n 1 24 THR n 1 25 VAL n 1 26 THR n 1 27 ALA n 1 28 PHE n 1 29 LEU n 1 30 GLY n 1 31 ILE n 1 32 PRO n 1 33 TYR n 1 34 ALA n 1 35 GLN n 1 36 PRO n 1 37 PRO n 1 38 LEU n 1 39 GLY n 1 40 ARG n 1 41 LEU n 1 42 ARG n 1 43 PHE n 1 44 LYS n 1 45 LYS n 1 46 PRO n 1 47 GLN n 1 48 SER n 1 49 LEU n 1 50 THR n 1 51 LYS n 1 52 TRP n 1 53 SER n 1 54 ASP n 1 55 ILE n 1 56 TRP n 1 57 ASN n 1 58 ALA n 1 59 THR n 1 60 LYS n 1 61 TYR n 1 62 ALA n 1 63 ASN n 1 64 SER n 1 65 CYS n 1 66 CSS n 1 67 GLN n 1 68 ASN n 1 69 ILE n 1 70 ASP n 1 71 GLN n 1 72 SER n 1 73 PHE n 1 74 PRO n 1 75 GLY n 1 76 PHE n 1 77 HIS n 1 78 GLY n 1 79 SER n 1 80 GLU n 1 81 MET n 1 82 TRP n 1 83 ASN n 1 84 PRO n 1 85 ASN n 1 86 THR n 1 87 ASP n 1 88 LEU n 1 89 SER n 1 90 GLU n 1 91 ASP n 1 92 CYS n 1 93 LEU n 1 94 TYR n 1 95 LEU n 1 96 ASN n 1 97 VAL n 1 98 TRP n 1 99 ILE n 1 100 PRO n 1 101 ALA n 1 102 PRO n 1 103 LYS n 1 104 PRO n 1 105 LYS n 1 106 ASN n 1 107 ALA n 1 108 THR n 1 109 VAL n 1 110 LEU n 1 111 ILE n 1 112 TRP n 1 113 ILE n 1 114 TYR n 1 115 GLY n 1 116 GLY n 1 117 GLY n 1 118 PHE n 1 119 GLN n 1 120 THR n 1 121 GLY n 1 122 THR n 1 123 SER n 1 124 SER n 1 125 LEU n 1 126 HIS n 1 127 VAL n 1 128 TYR n 1 129 ASP n 1 130 GLY n 1 131 LYS n 1 132 PHE n 1 133 LEU n 1 134 ALA n 1 135 ARG n 1 136 VAL n 1 137 GLU n 1 138 ARG n 1 139 VAL n 1 140 ILE n 1 141 VAL n 1 142 VAL n 1 143 SER n 1 144 MET n 1 145 ASN n 1 146 TYR n 1 147 ARG n 1 148 VAL n 1 149 GLY n 1 150 ALA n 1 151 LEU n 1 152 GLY n 1 153 PHE n 1 154 LEU n 1 155 ALA n 1 156 LEU n 1 157 PRO n 1 158 GLY n 1 159 ASN n 1 160 PRO n 1 161 GLU n 1 162 ALA n 1 163 PRO n 1 164 GLY n 1 165 ASN n 1 166 MET n 1 167 GLY n 1 168 LEU n 1 169 PHE n 1 170 ASP n 1 171 GLN n 1 172 GLN n 1 173 LEU n 1 174 ALA n 1 175 LEU n 1 176 GLN n 1 177 TRP n 1 178 VAL n 1 179 GLN n 1 180 LYS n 1 181 ASN n 1 182 ILE n 1 183 ALA n 1 184 ALA n 1 185 PHE n 1 186 GLY n 1 187 GLY n 1 188 ASN n 1 189 PRO n 1 190 LYS n 1 191 SER n 1 192 VAL n 1 193 THR n 1 194 LEU n 1 195 PHE n 1 196 GLY n 1 197 GLU n 1 198 SER n 1 199 ALA n 1 200 GLY n 1 201 ALA n 1 202 ALA n 1 203 SER n 1 204 VAL n 1 205 SER n 1 206 LEU n 1 207 HIS n 1 208 LEU n 1 209 LEU n 1 210 SER n 1 211 PRO n 1 212 GLY n 1 213 SER n 1 214 HIS n 1 215 SER n 1 216 LEU n 1 217 PHE n 1 218 THR n 1 219 ARG n 1 220 ALA n 1 221 ILE n 1 222 LEU n 1 223 GLN n 1 224 SER n 1 225 GLY n 1 226 SER n 1 227 PHE n 1 228 ASN n 1 229 ALA n 1 230 PRO n 1 231 TRP n 1 232 ALA n 1 233 VAL n 1 234 THR n 1 235 SER n 1 236 LEU n 1 237 TYR n 1 238 GLU n 1 239 ALA n 1 240 ARG n 1 241 ASN n 1 242 ARG n 1 243 THR n 1 244 LEU n 1 245 ASN n 1 246 LEU n 1 247 ALA n 1 248 LYS n 1 249 LEU n 1 250 THR n 1 251 GLY n 1 252 CYS n 1 253 SER n 1 254 ARG n 1 255 GLU n 1 256 ASN n 1 257 GLU n 1 258 THR n 1 259 GLU n 1 260 ILE n 1 261 ILE n 1 262 LYS n 1 263 CYS n 1 264 LEU n 1 265 ARG n 1 266 ASN n 1 267 LYS n 1 268 ASP n 1 269 PRO n 1 270 GLN n 1 271 GLU n 1 272 ILE n 1 273 LEU n 1 274 LEU n 1 275 ASN n 1 276 GLU n 1 277 ALA n 1 278 PHE n 1 279 VAL n 1 280 VAL n 1 281 PRO n 1 282 TYR n 1 283 GLY n 1 284 THR n 1 285 PRO n 1 286 LEU n 1 287 SER n 1 288 VAL n 1 289 ASN n 1 290 PHE n 1 291 GLY n 1 292 PRO n 1 293 THR n 1 294 VAL n 1 295 ASP n 1 296 GLY n 1 297 ASP n 1 298 PHE n 1 299 LEU n 1 300 THR n 1 301 ASP n 1 302 MET n 1 303 PRO n 1 304 ASP n 1 305 ILE n 1 306 LEU n 1 307 LEU n 1 308 GLU n 1 309 LEU n 1 310 GLY n 1 311 GLN n 1 312 PHE n 1 313 LYS n 1 314 LYS n 1 315 THR n 1 316 GLN n 1 317 ILE n 1 318 LEU n 1 319 VAL n 1 320 GLY n 1 321 VAL n 1 322 ASN n 1 323 LYS n 1 324 ASP n 1 325 GLU n 1 326 GLY n 1 327 THR n 1 328 ALA n 1 329 PHE n 1 330 LEU n 1 331 VAL n 1 332 TYR n 1 333 GLY n 1 334 ALA n 1 335 PRO n 1 336 GLY n 1 337 PHE n 1 338 SER n 1 339 LYS n 1 340 ASP n 1 341 ASN n 1 342 ASN n 1 343 SER n 1 344 ILE n 1 345 ILE n 1 346 THR n 1 347 ARG n 1 348 LYS n 1 349 GLU n 1 350 PHE n 1 351 GLN n 1 352 GLU n 1 353 GLY n 1 354 LEU n 1 355 LYS n 1 356 ILE n 1 357 PHE n 1 358 PHE n 1 359 PRO n 1 360 GLY n 1 361 VAL n 1 362 SER n 1 363 GLU n 1 364 PHE n 1 365 GLY n 1 366 LYS n 1 367 GLU n 1 368 SER n 1 369 ILE n 1 370 LEU n 1 371 PHE n 1 372 HIS n 1 373 TYR n 1 374 THR n 1 375 ASP n 1 376 TRP n 1 377 VAL n 1 378 ASP n 1 379 ASP n 1 380 GLN n 1 381 ARG n 1 382 PRO n 1 383 GLU n 1 384 ASN n 1 385 TYR n 1 386 ARG n 1 387 GLU n 1 388 ALA n 1 389 LEU n 1 390 GLY n 1 391 ASP n 1 392 VAL n 1 393 VAL n 1 394 GLY n 1 395 ASP n 1 396 TYR n 1 397 ASN n 1 398 PHE n 1 399 ILE n 1 400 CYS n 1 401 PRO n 1 402 ALA n 1 403 LEU n 1 404 GLU n 1 405 PHE n 1 406 THR n 1 407 LYS n 1 408 LYS n 1 409 PHE n 1 410 SER n 1 411 GLU n 1 412 TRP n 1 413 GLY n 1 414 ASN n 1 415 ASN n 1 416 ALA n 1 417 PHE n 1 418 PHE n 1 419 TYR n 1 420 TYR n 1 421 PHE n 1 422 GLU n 1 423 HIS n 1 424 ARG n 1 425 SER n 1 426 SER n 1 427 LYS n 1 428 LEU n 1 429 PRO n 1 430 TRP n 1 431 PRO n 1 432 GLU n 1 433 TRP n 1 434 MET n 1 435 GLY n 1 436 VAL n 1 437 MET n 1 438 HIS n 1 439 GLY n 1 440 TYR n 1 441 GLU n 1 442 ILE n 1 443 GLU n 1 444 PHE n 1 445 VAL n 1 446 PHE n 1 447 GLY n 1 448 LEU n 1 449 PRO n 1 450 LEU n 1 451 GLU n 1 452 ARG n 1 453 ARG n 1 454 ASP n 1 455 GLN n 1 456 TYR n 1 457 THR n 1 458 LYS n 1 459 ALA n 1 460 GLU n 1 461 GLU n 1 462 ILE n 1 463 LEU n 1 464 SER n 1 465 ARG n 1 466 SER n 1 467 ILE n 1 468 VAL n 1 469 LYS n 1 470 ARG n 1 471 TRP n 1 472 ALA n 1 473 ASN n 1 474 PHE n 1 475 ALA n 1 476 LYS n 1 477 TYR n 1 478 GLY n 1 479 ASN n 1 480 PRO n 1 481 GLN n 1 482 GLU n 1 483 THR n 1 484 GLN n 1 485 ASN n 1 486 GLN n 1 487 SER n 1 488 THR n 1 489 SER n 1 490 TRP n 1 491 PRO n 1 492 VAL n 1 493 PHE n 1 494 LYS n 1 495 SER n 1 496 THR n 1 497 GLU n 1 498 GLN n 1 499 LYS n 1 500 TYR n 1 501 LEU n 1 502 THR n 1 503 LEU n 1 504 ASN n 1 505 THR n 1 506 GLU n 1 507 SER n 1 508 THR n 1 509 ARG n 1 510 ILE n 1 511 MET n 1 512 THR n 1 513 LYS n 1 514 LEU n 1 515 ARG n 1 516 ALA n 1 517 GLN n 1 518 GLN n 1 519 CYS n 1 520 ARG n 1 521 PHE n 1 522 TRP n 1 523 THR n 1 524 SER n 1 525 PHE n 1 526 PHE n 1 527 PRO n 1 528 LYS n 1 529 VAL n # _entity_src_gen.entity_id 1 _entity_src_gen.pdbx_src_id 1 _entity_src_gen.pdbx_alt_source_flag sample _entity_src_gen.pdbx_seq_type ? _entity_src_gen.pdbx_beg_seq_num ? _entity_src_gen.pdbx_end_seq_num ? _entity_src_gen.gene_src_common_name human _entity_src_gen.gene_src_genus Homo _entity_src_gen.pdbx_gene_src_gene ? _entity_src_gen.gene_src_species ? _entity_src_gen.gene_src_strain ? _entity_src_gen.gene_src_tissue ? _entity_src_gen.gene_src_tissue_fraction ? _entity_src_gen.gene_src_details ? _entity_src_gen.pdbx_gene_src_fragment ? _entity_src_gen.pdbx_gene_src_scientific_name 'Homo sapiens' _entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 9606 _entity_src_gen.pdbx_gene_src_variant ? _entity_src_gen.pdbx_gene_src_cell_line ? _entity_src_gen.pdbx_gene_src_atcc ? _entity_src_gen.pdbx_gene_src_organ ? _entity_src_gen.pdbx_gene_src_organelle ? _entity_src_gen.pdbx_gene_src_cell ? _entity_src_gen.pdbx_gene_src_cellular_location ? _entity_src_gen.host_org_common_name 'Chinese hamster' _entity_src_gen.pdbx_host_org_scientific_name 'Cricetulus griseus' _entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 10029 _entity_src_gen.host_org_genus Cricetulus _entity_src_gen.pdbx_host_org_gene ? _entity_src_gen.pdbx_host_org_organ ? _entity_src_gen.host_org_species ? _entity_src_gen.pdbx_host_org_tissue ? _entity_src_gen.pdbx_host_org_tissue_fraction ? _entity_src_gen.pdbx_host_org_strain ? _entity_src_gen.pdbx_host_org_variant ? _entity_src_gen.pdbx_host_org_cell_line ? _entity_src_gen.pdbx_host_org_atcc ? _entity_src_gen.pdbx_host_org_culture_collection ? _entity_src_gen.pdbx_host_org_cell 'Baby Hampster Kidney Cells' _entity_src_gen.pdbx_host_org_organelle ? _entity_src_gen.pdbx_host_org_cellular_location ? _entity_src_gen.pdbx_host_org_vector_type Plasmid _entity_src_gen.pdbx_host_org_vector ? _entity_src_gen.host_org_details ? _entity_src_gen.expression_system_id ? _entity_src_gen.plasmid_name PGS _entity_src_gen.plasmid_details ? _entity_src_gen.pdbx_description ? # _struct_ref.id 1 _struct_ref.entity_id 1 _struct_ref.db_name UNP _struct_ref.db_code CHLE_HUMAN _struct_ref.pdbx_db_accession P06276 _struct_ref.pdbx_align_begin 29 _struct_ref.pdbx_seq_one_letter_code ;EDDIIIATKNGKVRGMNLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATKYANSCCQNIDQSFPGFHGSE MWNPNTDLSEDCLYLNVWIPAPKPKNATVLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNP EAPGNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPGSHSLFTRAILQSGSFNAPWAVTSLYEAR NRTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTPLSVNFGPTVDGDFLTDMPDILLELGQFKKTQILVG VNKDEGTAFLVYGAPGFSKDNNSIITRKEFQEGLKIFFPGVSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFIC PALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDNYTKAEEILSRSIVKRWANFAKYGNP NETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWTSFFPKV ; _struct_ref.pdbx_db_isoform ? # _struct_ref_seq.align_id 1 _struct_ref_seq.ref_id 1 _struct_ref_seq.pdbx_PDB_id_code 1XLV _struct_ref_seq.pdbx_strand_id A _struct_ref_seq.seq_align_beg 1 _struct_ref_seq.pdbx_seq_align_beg_ins_code ? _struct_ref_seq.seq_align_end 529 _struct_ref_seq.pdbx_seq_align_end_ins_code ? _struct_ref_seq.pdbx_db_accession P06276 _struct_ref_seq.db_align_beg 29 _struct_ref_seq.pdbx_db_align_beg_ins_code ? _struct_ref_seq.db_align_end 557 _struct_ref_seq.pdbx_db_align_end_ins_code ? _struct_ref_seq.pdbx_auth_seq_align_beg 1 _struct_ref_seq.pdbx_auth_seq_align_end 529 # loop_ _struct_ref_seq_dif.align_id _struct_ref_seq_dif.pdbx_pdb_id_code _struct_ref_seq_dif.mon_id _struct_ref_seq_dif.pdbx_pdb_strand_id _struct_ref_seq_dif.seq_num _struct_ref_seq_dif.pdbx_pdb_ins_code _struct_ref_seq_dif.pdbx_seq_db_name _struct_ref_seq_dif.pdbx_seq_db_accession_code _struct_ref_seq_dif.db_mon_id _struct_ref_seq_dif.pdbx_seq_db_seq_num _struct_ref_seq_dif.details _struct_ref_seq_dif.pdbx_auth_seq_num _struct_ref_seq_dif.pdbx_ordinal 1 1XLV GLN A 17 ? UNP P06276 ASN 45 ENGINEERED 17 1 1 1XLV GLN A 455 ? UNP P06276 ASN 483 ENGINEERED 455 2 1 1XLV GLN A 481 ? UNP P06276 ASN 509 ENGINEERED 481 3 1 1XLV GLN A 486 ? UNP P06276 ASN 514 ENGINEERED 486 4 # loop_ _chem_comp.id _chem_comp.type _chem_comp.mon_nstd_flag _chem_comp.name _chem_comp.pdbx_synonyms _chem_comp.formula _chem_comp.formula_weight ALA 'L-peptide linking' y ALANINE ? 'C3 H7 N O2' 89.093 ARG 'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1' 175.209 ASN 'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3' 132.118 ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4' 133.103 CL non-polymer . 'CHLORIDE ION' ? 'Cl -1' 35.453 CSS 'L-peptide linking' n S-MERCAPTOCYSTEINE ? 'C3 H7 N O2 S2' 153.223 CYS 'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S' 121.158 EFS non-polymer . 'ETHYL DIHYDROGEN PHOSPHATE' ? 'C2 H7 O4 P' 126.048 FUL L-saccharide . BETA-L-FUCOSE 6-DEOXY-BETA-L-GALACTOSE 'C6 H12 O5' 164.156 GLN 'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3' 146.144 GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4' 147.129 GLY 'peptide linking' y GLYCINE ? 'C2 H5 N O2' 75.067 GOL non-polymer . GLYCEROL 'GLYCERIN; PROPANE-1,2,3-TRIOL' 'C3 H8 O3' 92.094 HIS 'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1' 156.162 HOH non-polymer . WATER ? 'H2 O' 18.015 ILE 'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2' 131.173 LEU 'L-peptide linking' y LEUCINE ? 'C6 H13 N O2' 131.173 LYS 'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1' 147.195 MET 'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S' 149.211 NAG D-saccharide . N-ACETYL-D-GLUCOSAMINE ? 'C8 H15 N O6' 221.208 PHE 'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2' 165.189 PRO 'L-peptide linking' y PROLINE ? 'C5 H9 N O2' 115.130 SER 'L-peptide linking' y SERINE ? 'C3 H7 N O3' 105.093 SO4 non-polymer . 'SULFATE ION' ? 'O4 S -2' 96.063 THR 'L-peptide linking' y THREONINE ? 'C4 H9 N O3' 119.119 TRP 'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2' 204.225 TYR 'L-peptide linking' y TYROSINE ? 'C9 H11 N O3' 181.189 VAL 'L-peptide linking' y VALINE ? 'C5 H11 N O2' 117.146 # _exptl.entry_id 1XLV _exptl.method 'X-RAY DIFFRACTION' _exptl.crystals_number 1 # _exptl_crystal.id 1 _exptl_crystal.density_percent_sol 57.1 _exptl_crystal.density_Matthews 2.9 _exptl_crystal.density_meas ? _exptl_crystal.description ? _exptl_crystal.F_000 ? _exptl_crystal.preparation ? # _exptl_crystal_grow.crystal_id 1 _exptl_crystal_grow.method 'VAPOR DIFFUSION, HANGING DROP' _exptl_crystal_grow.temp 298 _exptl_crystal_grow.pH 6.5 _exptl_crystal_grow.pdbx_details 'AMMONIUM SULFATE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K' _exptl_crystal_grow.temp_details ? _exptl_crystal_grow.pdbx_pH_range . # _diffrn.id 1 _diffrn.ambient_temp 100. _diffrn.ambient_temp_details ? _diffrn.crystal_id 1 # _diffrn_detector.diffrn_id 1 _diffrn_detector.detector 'IMAGE PLATE' _diffrn_detector.type 'RIGAKU RAXIS IV' _diffrn_detector.pdbx_collection_date 2003-12-19 _diffrn_detector.details ? # _diffrn_radiation.diffrn_id 1 _diffrn_radiation.wavelength_id 1 _diffrn_radiation.pdbx_monochromatic_or_laue_m_l M _diffrn_radiation.monochromator ? _diffrn_radiation.pdbx_diffrn_protocol 'SINGLE WAVELENGTH' _diffrn_radiation.pdbx_scattering_type x-ray # _diffrn_radiation_wavelength.id 1 _diffrn_radiation_wavelength.wavelength 1.5418 _diffrn_radiation_wavelength.wt 1.0 # _diffrn_source.diffrn_id 1 _diffrn_source.source 'ROTATING ANODE' _diffrn_source.type RIGAKU _diffrn_source.pdbx_synchrotron_site ? _diffrn_source.pdbx_synchrotron_beamline ? _diffrn_source.pdbx_wavelength ? _diffrn_source.pdbx_wavelength_list 1.5418 # _reflns.entry_id 1XLV _reflns.observed_criterion_sigma_F ? _reflns.observed_criterion_sigma_I ? _reflns.d_resolution_high 2.247 _reflns.d_resolution_low 50. _reflns.number_all ? _reflns.number_obs 31580 _reflns.percent_possible_obs 86.1 _reflns.pdbx_Rmerge_I_obs ? _reflns.pdbx_Rsym_value 0.051 _reflns.pdbx_netI_over_sigmaI 32.2 _reflns.B_iso_Wilson_estimate ? _reflns.pdbx_redundancy 7.8 _reflns.R_free_details ? _reflns.limit_h_max ? _reflns.limit_h_min ? _reflns.limit_k_max ? _reflns.limit_k_min ? _reflns.limit_l_max ? _reflns.limit_l_min ? _reflns.observed_criterion_F_max ? _reflns.observed_criterion_F_min ? _reflns.pdbx_chi_squared ? _reflns.pdbx_scaling_rejects ? _reflns.pdbx_ordinal 1 _reflns.pdbx_diffrn_id 1 # _reflns_shell.d_res_high 2.247 _reflns_shell.d_res_low 2.33 _reflns_shell.percent_possible_all 91.1 _reflns_shell.Rmerge_I_obs ? _reflns_shell.pdbx_Rsym_value 0.439 _reflns_shell.meanI_over_sigI_obs 3.3 _reflns_shell.pdbx_redundancy 6.3 _reflns_shell.percent_possible_obs ? _reflns_shell.number_unique_all ? _reflns_shell.number_measured_all ? _reflns_shell.number_measured_obs ? _reflns_shell.number_unique_obs ? _reflns_shell.pdbx_chi_squared ? _reflns_shell.pdbx_ordinal 1 _reflns_shell.pdbx_diffrn_id 1 # _refine.entry_id 1XLV _refine.ls_number_reflns_obs 27281 _refine.ls_number_reflns_all ? _refine.pdbx_ls_sigma_I ? _refine.pdbx_ls_sigma_F ? _refine.pdbx_data_cutoff_high_absF ? _refine.pdbx_data_cutoff_low_absF ? _refine.pdbx_data_cutoff_high_rms_absF ? _refine.ls_d_res_low 40.00 _refine.ls_d_res_high 2.247 _refine.ls_percent_reflns_obs 78.25 _refine.ls_R_factor_obs 0.18618 _refine.ls_R_factor_all ? _refine.ls_R_factor_R_work 0.18299 _refine.ls_R_factor_R_free 0.24662 _refine.ls_R_factor_R_free_error ? _refine.ls_R_factor_R_free_error_details ? _refine.ls_percent_reflns_R_free 5.0 _refine.ls_number_reflns_R_free 1447 _refine.ls_number_parameters ? _refine.ls_number_restraints ? _refine.occupancy_min ? _refine.occupancy_max ? _refine.correlation_coeff_Fo_to_Fc 0.954 _refine.correlation_coeff_Fo_to_Fc_free 0.921 _refine.B_iso_mean 48.278 _refine.aniso_B[1][1] -1.80 _refine.aniso_B[2][2] -1.80 _refine.aniso_B[3][3] 3.59 _refine.aniso_B[1][2] 0.00 _refine.aniso_B[1][3] 0.00 _refine.aniso_B[2][3] 0.00 _refine.solvent_model_details MASK _refine.solvent_model_param_ksol ? _refine.solvent_model_param_bsol ? _refine.pdbx_solvent_vdw_probe_radii 1.20 _refine.pdbx_solvent_ion_probe_radii 0.80 _refine.pdbx_solvent_shrinkage_radii 0.80 _refine.pdbx_ls_cross_valid_method THROUGHOUT _refine.details ? _refine.pdbx_starting_model 1POI _refine.pdbx_method_to_determine_struct 'MOLECULAR REPLACEMENT' _refine.pdbx_isotropic_thermal_model ? _refine.pdbx_stereochemistry_target_values 'MAXIMUM LIKELIHOOD' _refine.pdbx_stereochem_target_val_spec_case ? _refine.pdbx_R_Free_selection_details RANDOM _refine.pdbx_overall_ESU_R 0.335 _refine.pdbx_overall_ESU_R_Free 0.253 _refine.overall_SU_ML 0.152 _refine.overall_SU_B 6.161 _refine.ls_redundancy_reflns_obs ? _refine.B_iso_min ? _refine.B_iso_max ? _refine.overall_SU_R_Cruickshank_DPI ? _refine.overall_SU_R_free ? _refine.ls_wR_factor_R_free ? _refine.ls_wR_factor_R_work ? _refine.overall_FOM_free_R_set ? _refine.overall_FOM_work_R_set ? _refine.pdbx_overall_phase_error ? _refine.pdbx_refine_id 'X-RAY DIFFRACTION' _refine.pdbx_diffrn_id 1 _refine.pdbx_TLS_residual_ADP_flag ? _refine.pdbx_overall_SU_R_free_Cruickshank_DPI ? _refine.pdbx_overall_SU_R_Blow_DPI ? _refine.pdbx_overall_SU_R_free_Blow_DPI ? # _refine_hist.pdbx_refine_id 'X-RAY DIFFRACTION' _refine_hist.cycle_id LAST _refine_hist.pdbx_number_atoms_protein 4180 _refine_hist.pdbx_number_atoms_nucleic_acid 0 _refine_hist.pdbx_number_atoms_ligand 170 _refine_hist.number_atoms_solvent 220 _refine_hist.number_atoms_total 4570 _refine_hist.d_res_high 2.247 _refine_hist.d_res_low 40.00 # loop_ _refine_ls_restr.type _refine_ls_restr.dev_ideal _refine_ls_restr.dev_ideal_target _refine_ls_restr.weight _refine_ls_restr.number _refine_ls_restr.pdbx_refine_id _refine_ls_restr.pdbx_restraint_function r_bond_refined_d 0.018 0.022 ? 4591 'X-RAY DIFFRACTION' ? r_bond_other_d ? ? ? ? 'X-RAY DIFFRACTION' ? r_angle_refined_deg 1.744 1.966 ? 6252 'X-RAY DIFFRACTION' ? r_angle_other_deg ? ? ? ? 'X-RAY DIFFRACTION' ? r_dihedral_angle_1_deg 6.815 5.000 ? 544 'X-RAY DIFFRACTION' ? r_dihedral_angle_2_deg 37.357 24.000 ? 210 'X-RAY DIFFRACTION' ? r_dihedral_angle_3_deg 17.789 15.000 ? 718 'X-RAY DIFFRACTION' ? r_dihedral_angle_4_deg 16.537 15.000 ? 23 'X-RAY DIFFRACTION' ? r_chiral_restr 0.115 0.200 ? 669 'X-RAY DIFFRACTION' ? r_gen_planes_refined 0.007 0.020 ? 3491 'X-RAY DIFFRACTION' ? r_gen_planes_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_nbd_refined 0.226 0.200 ? 2269 'X-RAY DIFFRACTION' ? r_nbd_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_nbtor_refined 0.317 0.200 ? 3112 'X-RAY DIFFRACTION' ? r_nbtor_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_xyhbond_nbd_refined 0.168 0.200 ? 287 'X-RAY DIFFRACTION' ? r_xyhbond_nbd_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_metal_ion_refined ? ? ? ? 'X-RAY DIFFRACTION' ? r_metal_ion_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_symmetry_vdw_refined 0.230 0.200 ? 47 'X-RAY DIFFRACTION' ? r_symmetry_vdw_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_symmetry_hbond_refined 0.203 0.200 ? 8 'X-RAY DIFFRACTION' ? r_symmetry_hbond_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_mcbond_it 1.158 1.500 ? 2740 'X-RAY DIFFRACTION' ? r_mcbond_other ? ? ? ? 'X-RAY DIFFRACTION' ? r_mcangle_it 1.659 2.000 ? 4328 'X-RAY DIFFRACTION' ? r_scbond_it 2.648 3.000 ? 2120 'X-RAY DIFFRACTION' ? r_scangle_it 3.699 4.500 ? 1924 'X-RAY DIFFRACTION' ? r_rigid_bond_restr ? ? ? ? 'X-RAY DIFFRACTION' ? r_sphericity_free ? ? ? ? 'X-RAY DIFFRACTION' ? r_sphericity_bonded ? ? ? ? 'X-RAY DIFFRACTION' ? # _refine_ls_shell.pdbx_total_number_of_bins_used 20 _refine_ls_shell.d_res_high 2.247 _refine_ls_shell.d_res_low 2.305 _refine_ls_shell.number_reflns_R_work 1875 _refine_ls_shell.R_factor_R_work 0.224 _refine_ls_shell.percent_reflns_obs 73.92 _refine_ls_shell.R_factor_R_free 0.296 _refine_ls_shell.R_factor_R_free_error ? _refine_ls_shell.percent_reflns_R_free ? _refine_ls_shell.number_reflns_R_free 109 _refine_ls_shell.number_reflns_obs ? _refine_ls_shell.redundancy_reflns_obs ? _refine_ls_shell.number_reflns_all ? _refine_ls_shell.R_factor_all ? _refine_ls_shell.pdbx_refine_id 'X-RAY DIFFRACTION' # _struct.entry_id 1XLV _struct.title 'Ethylphosphorylated Butyrylcholinesterase (Aged) Obtained By Reaction With Echothiophate' _struct.pdbx_descriptor 'BUTYRYLCHOLINESTERASE (E.C.3.1.1.8)' _struct.pdbx_model_details ? _struct.pdbx_CASP_flag ? _struct.pdbx_model_type_details ? # _struct_keywords.entry_id 1XLV _struct_keywords.pdbx_keywords HYDROLASE _struct_keywords.text 'CHOLINESTERASE; BChe, HYDROLASE' # loop_ _struct_asym.id _struct_asym.pdbx_blank_PDB_chainid_flag _struct_asym.pdbx_modified _struct_asym.entity_id _struct_asym.details A N N 1 ? B N N 2 ? C N N 2 ? D N N 3 ? E N N 2 ? F N N 2 ? G N N 2 ? H N N 2 ? I N N 2 ? J N N 2 ? K N N 4 ? L N N 4 ? M N N 4 ? N N N 5 ? O N N 5 ? P N N 5 ? Q N N 6 ? R N N 7 ? S N N 7 ? T N N 7 ? U N N 7 ? V N N 8 ? # _struct_biol.id 1 _struct_biol.pdbx_parent_biol_id ? _struct_biol.details ? # loop_ _struct_conf.conf_type_id _struct_conf.id _struct_conf.pdbx_PDB_helix_id _struct_conf.beg_label_comp_id _struct_conf.beg_label_asym_id _struct_conf.beg_label_seq_id _struct_conf.pdbx_beg_PDB_ins_code _struct_conf.end_label_comp_id _struct_conf.end_label_asym_id _struct_conf.end_label_seq_id _struct_conf.pdbx_end_PDB_ins_code _struct_conf.beg_auth_comp_id _struct_conf.beg_auth_asym_id _struct_conf.beg_auth_seq_id _struct_conf.end_auth_comp_id _struct_conf.end_auth_asym_id _struct_conf.end_auth_seq_id _struct_conf.pdbx_PDB_helix_class _struct_conf.details _struct_conf.pdbx_PDB_helix_length HELX_P HELX_P1 1 PHE A 76 ? MET A 81 ? PHE A 76 MET A 81 1 ? 6 HELX_P HELX_P2 2 LEU A 125 ? ASP A 129 ? LEU A 125 ASP A 129 5 ? 5 HELX_P HELX_P3 3 GLY A 130 ? ARG A 138 ? GLY A 130 ARG A 138 1 ? 9 HELX_P HELX_P4 4 GLY A 149 ? LEU A 154 ? GLY A 149 LEU A 154 1 ? 6 HELX_P HELX_P5 5 ASN A 165 ? ILE A 182 ? ASN A 165 ILE A 182 1 ? 18 HELX_P HELX_P6 6 ALA A 183 ? PHE A 185 ? ALA A 183 PHE A 185 5 ? 3 HELX_P HELX_P7 7 SER A 198 ? SER A 210 ? SER A 198 SER A 210 1 ? 13 HELX_P HELX_P8 8 PRO A 211 ? PHE A 217 ? PRO A 211 PHE A 217 5 ? 7 HELX_P HELX_P9 9 SER A 235 ? THR A 250 ? SER A 235 THR A 250 1 ? 16 HELX_P HELX_P10 10 ASN A 256 ? ARG A 265 ? ASN A 256 ARG A 265 1 ? 10 HELX_P HELX_P11 11 ASP A 268 ? ALA A 277 ? ASP A 268 ALA A 277 1 ? 10 HELX_P HELX_P12 12 MET A 302 ? LEU A 309 ? MET A 302 LEU A 309 1 ? 8 HELX_P HELX_P13 13 GLY A 326 ? VAL A 331 ? GLY A 326 VAL A 331 1 ? 6 HELX_P HELX_P14 14 THR A 346 ? PHE A 358 ? THR A 346 PHE A 358 1 ? 13 HELX_P HELX_P15 15 SER A 362 ? THR A 374 ? SER A 362 THR A 374 1 ? 13 HELX_P HELX_P16 16 GLU A 383 ? PHE A 398 ? GLU A 383 PHE A 398 1 ? 16 HELX_P HELX_P17 17 PHE A 398 ? GLU A 411 ? PHE A 398 GLU A 411 1 ? 14 HELX_P HELX_P18 18 PRO A 431 ? GLY A 435 ? PRO A 431 GLY A 435 5 ? 5 HELX_P HELX_P19 19 GLU A 441 ? GLY A 447 ? GLU A 441 GLY A 447 1 ? 7 HELX_P HELX_P20 20 LEU A 448 ? GLN A 455 ? LEU A 448 GLN A 455 5 ? 8 HELX_P HELX_P21 21 THR A 457 ? GLY A 478 ? THR A 457 GLY A 478 1 ? 22 HELX_P HELX_P22 22 ARG A 515 ? PHE A 525 ? ARG A 515 PHE A 525 1 ? 11 HELX_P HELX_P23 23 PHE A 526 ? VAL A 529 ? PHE A 526 VAL A 529 5 ? 4 # _struct_conf_type.id HELX_P _struct_conf_type.criteria ? _struct_conf_type.reference ? # loop_ _struct_conn.id _struct_conn.conn_type_id _struct_conn.pdbx_leaving_atom_flag _struct_conn.pdbx_PDB_id _struct_conn.ptnr1_label_asym_id _struct_conn.ptnr1_label_comp_id _struct_conn.ptnr1_label_seq_id _struct_conn.ptnr1_label_atom_id _struct_conn.pdbx_ptnr1_label_alt_id _struct_conn.pdbx_ptnr1_PDB_ins_code _struct_conn.pdbx_ptnr1_standard_comp_id _struct_conn.ptnr1_symmetry _struct_conn.ptnr2_label_asym_id _struct_conn.ptnr2_label_comp_id _struct_conn.ptnr2_label_seq_id _struct_conn.ptnr2_label_atom_id _struct_conn.pdbx_ptnr2_label_alt_id _struct_conn.pdbx_ptnr2_PDB_ins_code _struct_conn.ptnr1_auth_asym_id _struct_conn.ptnr1_auth_comp_id _struct_conn.ptnr1_auth_seq_id _struct_conn.ptnr2_auth_asym_id _struct_conn.ptnr2_auth_comp_id _struct_conn.ptnr2_auth_seq_id _struct_conn.ptnr2_symmetry _struct_conn.pdbx_ptnr3_label_atom_id _struct_conn.pdbx_ptnr3_label_seq_id _struct_conn.pdbx_ptnr3_label_comp_id _struct_conn.pdbx_ptnr3_label_asym_id _struct_conn.pdbx_ptnr3_label_alt_id _struct_conn.pdbx_ptnr3_PDB_ins_code _struct_conn.details _struct_conn.pdbx_dist_value _struct_conn.pdbx_value_order disulf1 disulf ? ? A CYS 65 SG ? ? ? 1_555 A CYS 92 SG ? ? A CYS 65 A CYS 92 1_555 ? ? ? ? ? ? ? 2.063 ? disulf2 disulf ? ? A CYS 252 SG ? ? ? 1_555 A CYS 263 SG ? ? A CYS 252 A CYS 263 1_555 ? ? ? ? ? ? ? 2.053 ? disulf3 disulf ? ? A CYS 400 SG ? ? ? 1_555 A CYS 519 SG ? ? A CYS 400 A CYS 519 1_555 ? ? ? ? ? ? ? 2.069 ? covale1 covale ? ? A CYS 65 C ? ? ? 1_555 A CSS 66 N ? ? A CYS 65 A CSS 66 1_555 ? ? ? ? ? ? ? 1.340 ? covale2 covale ? ? A CSS 66 C ? ? ? 1_555 A GLN 67 N ? ? A CSS 66 A GLN 67 1_555 ? ? ? ? ? ? ? 1.319 ? covale3 covale ? ? A ASN 57 ND2 ? ? ? 1_555 H NAG . C1 ? ? A ASN 57 A NAG 536 1_555 ? ? ? ? ? ? ? 1.470 ? covale4 covale ? ? A ASN 106 ND2 ? ? ? 1_555 G NAG . C1 ? ? A ASN 106 A NAG 535 1_555 ? ? ? ? ? ? ? 1.443 ? covale5 covale ? ? A ASN 241 ND2 ? ? ? 1_555 B NAG . C1 ? ? A ASN 241 A NAG 530 1_555 ? ? ? ? ? ? ? 1.451 ? covale6 covale ? ? A ASN 256 ND2 ? ? ? 1_555 J NAG . C1 ? ? A ASN 256 A NAG 538 1_555 ? ? ? ? ? ? ? 1.460 ? covale7 covale ? ? A ASN 341 ND2 ? ? ? 1_555 E NAG . C1 ? ? A ASN 341 A NAG 533 1_555 ? ? ? ? ? ? ? 1.424 ? covale8 covale ? ? A ASN 485 ND2 ? ? ? 1_555 I NAG . C1 ? ? A ASN 485 A NAG 537 1_555 ? ? ? ? ? ? ? 1.439 ? covale9 covale ? ? B NAG . O4 ? ? ? 1_555 C NAG . C1 ? ? A NAG 530 A NAG 531 1_555 ? ? ? ? ? ? ? 1.446 ? covale10 covale ? ? B NAG . O6 ? ? ? 1_555 D FUL . C1 ? ? A NAG 530 A FUL 532 1_555 ? ? ? ? ? ? ? 1.429 ? covale11 covale ? ? E NAG . O4 ? ? ? 1_555 F NAG . C1 ? ? A NAG 533 A NAG 534 1_555 ? ? ? ? ? ? ? 1.438 ? covale12 covale ? ? A SER 198 OG ? ? ? 1_555 Q EFS . P ? ? A SER 198 A EFS 1001 1_555 ? ? ? ? ? ? ? 1.529 ? # loop_ _struct_conn_type.id _struct_conn_type.criteria _struct_conn_type.reference disulf ? ? covale ? ? # _struct_mon_prot_cis.pdbx_id 1 _struct_mon_prot_cis.label_comp_id ALA _struct_mon_prot_cis.label_seq_id 101 _struct_mon_prot_cis.label_asym_id A _struct_mon_prot_cis.label_alt_id . _struct_mon_prot_cis.pdbx_PDB_ins_code ? _struct_mon_prot_cis.auth_comp_id ALA _struct_mon_prot_cis.auth_seq_id 101 _struct_mon_prot_cis.auth_asym_id A _struct_mon_prot_cis.pdbx_label_comp_id_2 PRO _struct_mon_prot_cis.pdbx_label_seq_id_2 102 _struct_mon_prot_cis.pdbx_label_asym_id_2 A _struct_mon_prot_cis.pdbx_PDB_ins_code_2 ? _struct_mon_prot_cis.pdbx_auth_comp_id_2 PRO _struct_mon_prot_cis.pdbx_auth_seq_id_2 102 _struct_mon_prot_cis.pdbx_auth_asym_id_2 A _struct_mon_prot_cis.pdbx_PDB_model_num 1 _struct_mon_prot_cis.pdbx_omega_angle -1.78 # loop_ _struct_sheet.id _struct_sheet.type _struct_sheet.number_strands _struct_sheet.details A ? 3 ? B ? 11 ? # loop_ _struct_sheet_order.sheet_id _struct_sheet_order.range_id_1 _struct_sheet_order.range_id_2 _struct_sheet_order.offset _struct_sheet_order.sense A 1 2 ? anti-parallel A 2 3 ? parallel B 1 2 ? anti-parallel B 2 3 ? anti-parallel B 3 4 ? anti-parallel B 4 5 ? parallel B 5 6 ? parallel B 6 7 ? parallel B 7 8 ? parallel B 8 9 ? parallel B 9 10 ? parallel B 10 11 ? anti-parallel # loop_ _struct_sheet_range.sheet_id _struct_sheet_range.id _struct_sheet_range.beg_label_comp_id _struct_sheet_range.beg_label_asym_id _struct_sheet_range.beg_label_seq_id _struct_sheet_range.pdbx_beg_PDB_ins_code _struct_sheet_range.end_label_comp_id _struct_sheet_range.end_label_asym_id _struct_sheet_range.end_label_seq_id _struct_sheet_range.pdbx_end_PDB_ins_code _struct_sheet_range.beg_auth_comp_id _struct_sheet_range.beg_auth_asym_id _struct_sheet_range.beg_auth_seq_id _struct_sheet_range.end_auth_comp_id _struct_sheet_range.end_auth_asym_id _struct_sheet_range.end_auth_seq_id A 1 ILE A 5 ? ALA A 7 ? ILE A 5 ALA A 7 A 2 LYS A 12 ? ARG A 14 ? LYS A 12 ARG A 14 A 3 ILE A 55 ? ASN A 57 ? ILE A 55 ASN A 57 B 1 MET A 16 ? VAL A 20 ? MET A 16 VAL A 20 B 2 GLY A 23 ? PRO A 32 ? GLY A 23 PRO A 32 B 3 TYR A 94 ? ALA A 101 ? TYR A 94 ALA A 101 B 4 ILE A 140 ? MET A 144 ? ILE A 140 MET A 144 B 5 ALA A 107 ? ILE A 113 ? ALA A 107 ILE A 113 B 6 GLY A 187 ? GLU A 197 ? GLY A 187 GLU A 197 B 7 ARG A 219 ? GLN A 223 ? ARG A 219 GLN A 223 B 8 ILE A 317 ? ASN A 322 ? ILE A 317 ASN A 322 B 9 ALA A 416 ? PHE A 421 ? ALA A 416 PHE A 421 B 10 LYS A 499 ? LEU A 503 ? LYS A 499 LEU A 503 B 11 ILE A 510 ? THR A 512 ? ILE A 510 THR A 512 # loop_ _pdbx_struct_sheet_hbond.sheet_id _pdbx_struct_sheet_hbond.range_id_1 _pdbx_struct_sheet_hbond.range_id_2 _pdbx_struct_sheet_hbond.range_1_label_atom_id _pdbx_struct_sheet_hbond.range_1_label_comp_id _pdbx_struct_sheet_hbond.range_1_label_asym_id _pdbx_struct_sheet_hbond.range_1_label_seq_id _pdbx_struct_sheet_hbond.range_1_PDB_ins_code _pdbx_struct_sheet_hbond.range_1_auth_atom_id _pdbx_struct_sheet_hbond.range_1_auth_comp_id _pdbx_struct_sheet_hbond.range_1_auth_asym_id _pdbx_struct_sheet_hbond.range_1_auth_seq_id _pdbx_struct_sheet_hbond.range_2_label_atom_id _pdbx_struct_sheet_hbond.range_2_label_comp_id _pdbx_struct_sheet_hbond.range_2_label_asym_id _pdbx_struct_sheet_hbond.range_2_label_seq_id _pdbx_struct_sheet_hbond.range_2_PDB_ins_code _pdbx_struct_sheet_hbond.range_2_auth_atom_id _pdbx_struct_sheet_hbond.range_2_auth_comp_id _pdbx_struct_sheet_hbond.range_2_auth_asym_id _pdbx_struct_sheet_hbond.range_2_auth_seq_id A 1 2 N ILE A 6 ? N ILE A 6 O VAL A 13 ? O VAL A 13 A 2 3 N ARG A 14 ? N ARG A 14 O TRP A 56 ? O TRP A 56 B 1 2 N LEU A 18 ? N LEU A 18 O VAL A 25 ? O VAL A 25 B 2 3 N ILE A 31 ? N ILE A 31 O LEU A 95 ? O LEU A 95 B 3 4 N ASN A 96 ? N ASN A 96 O SER A 143 ? O SER A 143 B 4 5 O ILE A 140 ? O ILE A 140 N LEU A 110 ? N LEU A 110 B 5 6 N VAL A 109 ? N VAL A 109 O THR A 193 ? O THR A 193 B 6 7 N LEU A 194 ? N LEU A 194 O ILE A 221 ? O ILE A 221 B 7 8 N LEU A 222 ? N LEU A 222 O LEU A 318 ? O LEU A 318 B 8 9 N VAL A 321 ? N VAL A 321 O PHE A 421 ? O PHE A 421 B 9 10 N PHE A 418 ? N PHE A 418 O LEU A 501 ? O LEU A 501 B 10 11 N TYR A 500 ? N TYR A 500 O MET A 511 ? O MET A 511 # loop_ _struct_site.id _struct_site.pdbx_evidence_code _struct_site.pdbx_auth_asym_id _struct_site.pdbx_auth_comp_id _struct_site.pdbx_auth_seq_id _struct_site.pdbx_auth_ins_code _struct_site.pdbx_num_residues _struct_site.details AC1 Software ? ? ? ? 6 'BINDING SITE FOR RESIDUE NAG A 530' AC2 Software ? ? ? ? 2 'BINDING SITE FOR RESIDUE NAG A 531' AC3 Software ? ? ? ? 6 'BINDING SITE FOR RESIDUE FUL A 532' AC4 Software ? ? ? ? 5 'BINDING SITE FOR RESIDUE NAG A 533' AC5 Software ? ? ? ? 2 'BINDING SITE FOR RESIDUE NAG A 534' AC6 Software ? ? ? ? 3 'BINDING SITE FOR RESIDUE NAG A 535' AC7 Software ? ? ? ? 1 'BINDING SITE FOR RESIDUE NAG A 536' AC8 Software ? ? ? ? 4 'BINDING SITE FOR RESIDUE NAG A 537' AC9 Software ? ? ? ? 1 'BINDING SITE FOR RESIDUE NAG A 538' BC1 Software ? ? ? ? 4 'BINDING SITE FOR RESIDUE SO4 A 601' BC2 Software ? ? ? ? 3 'BINDING SITE FOR RESIDUE SO4 A 602' BC3 Software ? ? ? ? 2 'BINDING SITE FOR RESIDUE SO4 A 603' BC4 Software ? ? ? ? 1 'BINDING SITE FOR RESIDUE CL A 701' BC5 Software ? ? ? ? 1 'BINDING SITE FOR RESIDUE CL A 702' BC6 Software ? ? ? ? 1 'BINDING SITE FOR RESIDUE CL A 703' BC7 Software ? ? ? ? 8 'BINDING SITE FOR RESIDUE EFS A 1001' BC8 Software ? ? ? ? 6 'BINDING SITE FOR RESIDUE GOL A 604' BC9 Software ? ? ? ? 7 'BINDING SITE FOR RESIDUE GOL A 605' CC1 Software ? ? ? ? 6 'BINDING SITE FOR RESIDUE GOL A 606' CC2 Software ? ? ? ? 9 'BINDING SITE FOR RESIDUE GOL A 607' # loop_ _struct_site_gen.id _struct_site_gen.site_id _struct_site_gen.pdbx_num_res _struct_site_gen.label_comp_id _struct_site_gen.label_asym_id _struct_site_gen.label_seq_id _struct_site_gen.pdbx_auth_ins_code _struct_site_gen.auth_comp_id _struct_site_gen.auth_asym_id _struct_site_gen.auth_seq_id _struct_site_gen.label_atom_id _struct_site_gen.label_alt_id _struct_site_gen.symmetry _struct_site_gen.details 1 AC1 6 TYR A 237 ? TYR A 237 . ? 1_555 ? 2 AC1 6 ASN A 241 ? ASN A 241 . ? 1_555 ? 3 AC1 6 ASN A 245 ? ASN A 245 . ? 1_555 ? 4 AC1 6 PRO A 281 ? PRO A 281 . ? 1_555 ? 5 AC1 6 NAG C . ? NAG A 531 . ? 1_555 ? 6 AC1 6 FUL D . ? FUL A 532 . ? 1_555 ? 7 AC2 2 NAG B . ? NAG A 530 . ? 1_555 ? 8 AC2 2 FUL D . ? FUL A 532 . ? 1_555 ? 9 AC3 6 ASN A 245 ? ASN A 245 . ? 1_555 ? 10 AC3 6 LEU A 249 ? LEU A 249 . ? 1_555 ? 11 AC3 6 PHE A 278 ? PHE A 278 . ? 1_555 ? 12 AC3 6 PRO A 281 ? PRO A 281 . ? 1_555 ? 13 AC3 6 NAG B . ? NAG A 530 . ? 1_555 ? 14 AC3 6 NAG C . ? NAG A 531 . ? 1_555 ? 15 AC4 5 SER A 338 ? SER A 338 . ? 1_555 ? 16 AC4 5 ASN A 341 ? ASN A 341 . ? 1_555 ? 17 AC4 5 ASN A 342 ? ASN A 342 . ? 1_555 ? 18 AC4 5 NAG F . ? NAG A 534 . ? 1_555 ? 19 AC4 5 HOH V . ? HOH A 1282 . ? 1_555 ? 20 AC5 2 GLY A 336 ? GLY A 336 . ? 1_555 ? 21 AC5 2 NAG E . ? NAG A 533 . ? 1_555 ? 22 AC6 3 ASN A 106 ? ASN A 106 . ? 1_555 ? 23 AC6 3 ASN A 188 ? ASN A 188 . ? 1_555 ? 24 AC6 3 LYS A 190 ? LYS A 190 . ? 1_555 ? 25 AC7 1 ASN A 57 ? ASN A 57 . ? 1_555 ? 26 AC8 4 ARG A 465 ? ARG A 465 . ? 1_555 ? 27 AC8 4 LYS A 469 ? LYS A 469 . ? 1_555 ? 28 AC8 4 ASN A 485 ? ASN A 485 . ? 1_555 ? 29 AC8 4 HOH V . ? HOH A 1212 . ? 1_555 ? 30 AC9 1 ASN A 256 ? ASN A 256 . ? 1_555 ? 31 BC1 4 GLN A 316 ? GLN A 316 . ? 1_555 ? 32 BC1 4 GLY A 413 ? GLY A 413 . ? 1_555 ? 33 BC1 4 ASN A 414 ? ASN A 414 . ? 1_555 ? 34 BC1 4 ASN A 415 ? ASN A 415 . ? 1_555 ? 35 BC2 3 HIS A 372 ? HIS A 372 . ? 1_555 ? 36 BC2 3 ARG A 520 ? ARG A 520 . ? 1_555 ? 37 BC2 3 PHE A 521 ? PHE A 521 . ? 1_555 ? 38 BC3 2 ARG A 347 ? ARG A 347 . ? 1_555 ? 39 BC3 2 GLN A 351 ? GLN A 351 . ? 1_555 ? 40 BC4 1 TYR A 420 ? TYR A 420 . ? 1_555 ? 41 BC5 1 THR A 508 ? THR A 508 . ? 1_555 ? 42 BC6 1 GLU A 363 ? GLU A 363 . ? 1_555 ? 43 BC7 8 GLY A 116 ? GLY A 116 . ? 1_555 ? 44 BC7 8 GLY A 117 ? GLY A 117 . ? 1_555 ? 45 BC7 8 SER A 198 ? SER A 198 . ? 1_555 ? 46 BC7 8 ALA A 199 ? ALA A 199 . ? 1_555 ? 47 BC7 8 TRP A 231 ? TRP A 231 . ? 1_555 ? 48 BC7 8 HIS A 438 ? HIS A 438 . ? 1_555 ? 49 BC7 8 GOL S . ? GOL A 605 . ? 1_555 ? 50 BC7 8 HOH V . ? HOH A 1309 . ? 1_555 ? 51 BC8 6 TRP A 231 ? TRP A 231 . ? 1_555 ? 52 BC8 6 THR A 234 ? THR A 234 . ? 1_555 ? 53 BC8 6 GLU A 238 ? GLU A 238 . ? 1_555 ? 54 BC8 6 ARG A 242 ? ARG A 242 . ? 1_555 ? 55 BC8 6 VAL A 288 ? VAL A 288 . ? 1_555 ? 56 BC8 6 HOH V . ? HOH A 1268 . ? 1_555 ? 57 BC9 7 TRP A 82 ? TRP A 82 . ? 1_555 ? 58 BC9 7 GLY A 115 ? GLY A 115 . ? 1_555 ? 59 BC9 7 GLY A 116 ? GLY A 116 . ? 1_555 ? 60 BC9 7 TYR A 128 ? TYR A 128 . ? 1_555 ? 61 BC9 7 GLU A 197 ? GLU A 197 . ? 1_555 ? 62 BC9 7 EFS Q . ? EFS A 1001 . ? 1_555 ? 63 BC9 7 HOH V . ? HOH A 1107 . ? 1_555 ? 64 CC1 6 LEU A 18 ? LEU A 18 . ? 1_555 ? 65 CC1 6 LEU A 29 ? LEU A 29 . ? 1_555 ? 66 CC1 6 TYR A 61 ? TYR A 61 . ? 1_555 ? 67 CC1 6 TRP A 98 ? TRP A 98 . ? 1_555 ? 68 CC1 6 ASP A 129 ? ASP A 129 . ? 1_555 ? 69 CC1 6 LYS A 131 ? LYS A 131 . ? 1_555 ? 70 CC2 9 MET A 81 ? MET A 81 . ? 1_555 ? 71 CC2 9 SER A 425 ? SER A 425 . ? 1_555 ? 72 CC2 9 LYS A 427 ? LYS A 427 . ? 1_555 ? 73 CC2 9 LEU A 428 ? LEU A 428 . ? 1_555 ? 74 CC2 9 TYR A 440 ? TYR A 440 . ? 1_555 ? 75 CC2 9 GLU A 443 ? GLU A 443 . ? 1_555 ? 76 CC2 9 TYR A 456 ? TYR A 456 . ? 1_555 ? 77 CC2 9 HOH V . ? HOH A 1196 . ? 1_555 ? 78 CC2 9 HOH V . ? HOH A 1296 . ? 1_555 ? # _atom_sites.entry_id 1XLV _atom_sites.fract_transf_matrix[1][1] 0.006469 _atom_sites.fract_transf_matrix[1][2] 0.000000 _atom_sites.fract_transf_matrix[1][3] 0.000000 _atom_sites.fract_transf_matrix[2][1] 0.000000 _atom_sites.fract_transf_matrix[2][2] 0.006469 _atom_sites.fract_transf_matrix[2][3] 0.000000 _atom_sites.fract_transf_matrix[3][1] 0.000000 _atom_sites.fract_transf_matrix[3][2] 0.000000 _atom_sites.fract_transf_matrix[3][3] 0.007892 _atom_sites.fract_transf_vector[1] 0.00000 _atom_sites.fract_transf_vector[2] 0.00000 _atom_sites.fract_transf_vector[3] 0.00000 # loop_ _atom_type.symbol C CL N O P S # loop_ _atom_site.group_PDB _atom_site.id _atom_site.type_symbol _atom_site.label_atom_id _atom_site.label_alt_id _atom_site.label_comp_id _atom_site.label_asym_id _atom_site.label_entity_id _atom_site.label_seq_id _atom_site.pdbx_PDB_ins_code _atom_site.Cartn_x _atom_site.Cartn_y _atom_site.Cartn_z _atom_site.occupancy _atom_site.B_iso_or_equiv _atom_site.pdbx_formal_charge _atom_site.auth_seq_id _atom_site.auth_comp_id _atom_site.auth_asym_id _atom_site.auth_atom_id _atom_site.pdbx_PDB_model_num ATOM 1 N N . ILE A 1 4 ? 135.871 34.509 14.422 1.00 68.55 ? 4 ILE A N 1 ATOM 2 C CA . ILE A 1 4 ? 136.741 33.366 14.894 1.00 69.00 ? 4 ILE A CA 1 ATOM 3 C C . ILE A 1 4 ? 136.206 32.008 14.397 1.00 68.17 ? 4 ILE A C 1 ATOM 4 O O . ILE A 1 4 ? 135.112 31.575 14.796 1.00 68.68 ? 4 ILE A O 1 ATOM 5 C CB . ILE A 1 4 ? 136.885 33.359 16.443 1.00 69.17 ? 4 ILE A CB 1 ATOM 6 C CG1 . ILE A 1 4 ? 136.472 34.719 17.055 1.00 70.97 ? 4 ILE A CG1 1 ATOM 7 C CG2 . ILE A 1 4 ? 138.313 32.941 16.849 1.00 69.63 ? 4 ILE A CG2 1 ATOM 8 C CD1 . ILE A 1 4 ? 134.915 35.028 17.084 1.00 70.62 ? 4 ILE A CD1 1 ATOM 9 N N . ILE A 1 5 ? 136.972 31.349 13.522 1.00 66.78 ? 5 ILE A N 1 ATOM 10 C CA . ILE A 1 5 ? 136.521 30.127 12.889 1.00 65.14 ? 5 ILE A CA 1 ATOM 11 C C . ILE A 1 5 ? 137.452 28.958 13.198 1.00 64.76 ? 5 ILE A C 1 ATOM 12 O O . ILE A 1 5 ? 138.618 28.926 12.752 1.00 64.25 ? 5 ILE A O 1 ATOM 13 C CB . ILE A 1 5 ? 136.342 30.319 11.369 1.00 65.26 ? 5 ILE A CB 1 ATOM 14 C CG1 . ILE A 1 5 ? 135.122 31.205 11.076 1.00 65.29 ? 5 ILE A CG1 1 ATOM 15 C CG2 . ILE A 1 5 ? 136.148 28.969 10.675 1.00 64.12 ? 5 ILE A CG2 1 ATOM 16 C CD1 . ILE A 1 5 ? 135.442 32.581 10.551 1.00 64.96 ? 5 ILE A CD1 1 ATOM 17 N N . ILE A 1 6 ? 136.926 27.997 13.962 1.00 63.43 ? 6 ILE A N 1 ATOM 18 C CA . ILE A 1 6 ? 137.686 26.806 14.330 1.00 62.66 ? 6 ILE A CA 1 ATOM 19 C C . ILE A 1 6 ? 137.336 25.670 13.381 1.00 62.89 ? 6 ILE A C 1 ATOM 20 O O . ILE A 1 6 ? 136.180 25.472 13.050 1.00 62.24 ? 6 ILE A O 1 ATOM 21 C CB . ILE A 1 6 ? 137.430 26.426 15.799 1.00 61.94 ? 6 ILE A CB 1 ATOM 22 C CG1 . ILE A 1 6 ? 137.718 27.616 16.733 1.00 61.80 ? 6 ILE A CG1 1 ATOM 23 C CG2 . ILE A 1 6 ? 138.213 25.185 16.191 1.00 61.23 ? 6 ILE A CG2 1 ATOM 24 C CD1 . ILE A 1 6 ? 139.187 27.882 17.120 1.00 59.39 ? 6 ILE A CD1 1 ATOM 25 N N . ALA A 1 7 ? 138.353 24.957 12.904 1.00 63.51 ? 7 ALA A N 1 ATOM 26 C CA . ALA A 1 7 ? 138.134 23.748 12.126 1.00 63.69 ? 7 ALA A CA 1 ATOM 27 C C . ALA A 1 7 ? 137.988 22.539 13.053 1.00 63.93 ? 7 ALA A C 1 ATOM 28 O O . ALA A 1 7 ? 138.887 22.259 13.837 1.00 63.76 ? 7 ALA A O 1 ATOM 29 C CB . ALA A 1 7 ? 139.279 23.531 11.159 1.00 63.95 ? 7 ALA A CB 1 ATOM 30 N N . THR A 1 8 ? 136.860 21.829 12.957 1.00 64.05 ? 8 THR A N 1 ATOM 31 C CA . THR A 1 8 ? 136.640 20.594 13.723 1.00 64.21 ? 8 THR A CA 1 ATOM 32 C C . THR A 1 8 ? 136.713 19.389 12.779 1.00 65.05 ? 8 THR A C 1 ATOM 33 O O . THR A 1 8 ? 136.828 19.580 11.562 1.00 65.42 ? 8 THR A O 1 ATOM 34 C CB . THR A 1 8 ? 135.273 20.630 14.483 1.00 64.27 ? 8 THR A CB 1 ATOM 35 O OG1 . THR A 1 8 ? 134.183 20.327 13.590 1.00 63.90 ? 8 THR A OG1 1 ATOM 36 C CG2 . THR A 1 8 ? 134.979 22.034 15.030 1.00 62.15 ? 8 THR A CG2 1 ATOM 37 N N . LYS A 1 9 ? 136.627 18.166 13.318 1.00 65.42 ? 9 LYS A N 1 ATOM 38 C CA . LYS A 1 9 ? 136.662 16.938 12.490 1.00 66.06 ? 9 LYS A CA 1 ATOM 39 C C . LYS A 1 9 ? 135.558 16.937 11.434 1.00 66.38 ? 9 LYS A C 1 ATOM 40 O O . LYS A 1 9 ? 135.766 16.438 10.324 1.00 66.57 ? 9 LYS A O 1 ATOM 41 C CB . LYS A 1 9 ? 136.597 15.639 13.338 1.00 65.89 ? 9 LYS A CB 1 ATOM 42 C CG . LYS A 1 9 ? 137.776 15.411 14.331 1.00 66.64 ? 9 LYS A CG 1 ATOM 43 C CD . LYS A 1 9 ? 139.072 14.952 13.686 1.00 68.20 ? 9 LYS A CD 1 ATOM 44 C CE . LYS A 1 9 ? 140.298 15.536 14.396 1.00 71.20 ? 9 LYS A CE 1 ATOM 45 N NZ . LYS A 1 9 ? 140.333 17.048 14.318 1.00 72.34 ? 9 LYS A NZ 1 ATOM 46 N N . ASN A 1 10 ? 134.407 17.522 11.784 1.00 66.75 ? 10 ASN A N 1 ATOM 47 C CA . ASN A 1 10 ? 133.202 17.556 10.933 1.00 66.87 ? 10 ASN A CA 1 ATOM 48 C C . ASN A 1 10 ? 132.936 18.804 10.105 1.00 66.05 ? 10 ASN A C 1 ATOM 49 O O . ASN A 1 10 ? 132.152 18.759 9.166 1.00 66.53 ? 10 ASN A O 1 ATOM 50 C CB . ASN A 1 10 ? 131.965 17.327 11.783 1.00 67.44 ? 10 ASN A CB 1 ATOM 51 C CG . ASN A 1 10 ? 131.721 15.892 12.025 1.00 70.47 ? 10 ASN A CG 1 ATOM 52 O OD1 . ASN A 1 10 ? 131.694 15.449 13.171 1.00 74.01 ? 10 ASN A OD1 1 ATOM 53 N ND2 . ASN A 1 10 ? 131.582 15.123 10.943 1.00 71.96 ? 10 ASN A ND2 1 ATOM 54 N N . GLY A 1 11 ? 133.534 19.923 10.477 1.00 64.74 ? 11 GLY A N 1 ATOM 55 C CA . GLY A 1 11 ? 133.355 21.134 9.718 1.00 63.25 ? 11 GLY A CA 1 ATOM 56 C C . GLY A 1 11 ? 133.869 22.303 10.524 1.00 62.57 ? 11 GLY A C 1 ATOM 57 O O . GLY A 1 11 ? 134.296 22.129 11.666 1.00 62.60 ? 11 GLY A O 1 ATOM 58 N N . LYS A 1 12 ? 133.854 23.485 9.911 1.00 61.26 ? 12 LYS A N 1 ATOM 59 C CA . LYS A 1 12 ? 134.243 24.715 10.570 1.00 60.12 ? 12 LYS A CA 1 ATOM 60 C C . LYS A 1 12 ? 133.067 25.255 11.406 1.00 59.37 ? 12 LYS A C 1 ATOM 61 O O . LYS A 1 12 ? 131.913 25.098 11.043 1.00 58.83 ? 12 LYS A O 1 ATOM 62 C CB . LYS A 1 12 ? 134.693 25.756 9.542 0.50 59.78 ? 12 LYS A CB 1 ATOM 63 C CG . LYS A 1 12 ? 136.018 25.449 8.873 0.50 59.75 ? 12 LYS A CG 1 ATOM 64 C CD . LYS A 1 12 ? 136.430 26.575 7.931 0.50 59.19 ? 12 LYS A CD 1 ATOM 65 C CE . LYS A 1 12 ? 137.805 26.324 7.334 0.10 59.20 ? 12 LYS A CE 1 ATOM 66 N NZ . LYS A 1 12 ? 138.264 27.469 6.504 0.10 58.83 ? 12 LYS A NZ 1 ATOM 67 N N . VAL A 1 13 ? 133.382 25.880 12.532 1.00 58.73 ? 13 VAL A N 1 ATOM 68 C CA . VAL A 1 13 ? 132.382 26.481 13.382 1.00 58.43 ? 13 VAL A CA 1 ATOM 69 C C . VAL A 1 13 ? 132.825 27.889 13.774 1.00 58.90 ? 13 VAL A C 1 ATOM 70 O O . VAL A 1 13 ? 133.981 28.116 14.132 1.00 58.90 ? 13 VAL A O 1 ATOM 71 C CB . VAL A 1 13 ? 132.018 25.610 14.663 1.00 57.95 ? 13 VAL A CB 1 ATOM 72 C CG1 . VAL A 1 13 ? 131.549 24.191 14.300 1.00 56.70 ? 13 VAL A CG1 1 ATOM 73 C CG2 . VAL A 1 13 ? 133.177 25.542 15.648 1.00 58.28 ? 13 VAL A CG2 1 ATOM 74 N N . ARG A 1 14 ? 131.877 28.821 13.716 1.00 59.36 ? 14 ARG A N 1 ATOM 75 C CA . ARG A 1 14 ? 132.095 30.206 14.091 1.00 59.54 ? 14 ARG A CA 1 ATOM 76 C C . ARG A 1 14 ? 131.478 30.500 15.457 1.00 58.91 ? 14 ARG A C 1 ATOM 77 O O . ARG A 1 14 ? 130.332 30.137 15.746 1.00 58.23 ? 14 ARG A O 1 ATOM 78 C CB . ARG A 1 14 ? 131.477 31.127 13.024 1.00 60.25 ? 14 ARG A CB 1 ATOM 79 C CG . ARG A 1 14 ? 131.397 32.617 13.401 1.00 62.82 ? 14 ARG A CG 1 ATOM 80 C CD . ARG A 1 14 ? 130.753 33.492 12.323 1.00 67.17 ? 14 ARG A CD 1 ATOM 81 N NE . ARG A 1 14 ? 131.721 33.847 11.278 1.00 70.11 ? 14 ARG A NE 1 ATOM 82 C CZ . ARG A 1 14 ? 131.676 33.437 10.009 1.00 71.02 ? 14 ARG A CZ 1 ATOM 83 N NH1 . ARG A 1 14 ? 130.681 32.642 9.581 1.00 69.27 ? 14 ARG A NH1 1 ATOM 84 N NH2 . ARG A 1 14 ? 132.645 33.837 9.167 1.00 70.66 ? 14 ARG A NH2 1 ATOM 85 N N . GLY A 1 15 ? 132.259 31.173 16.286 1.00 58.68 ? 15 GLY A N 1 ATOM 86 C CA . GLY A 1 15 ? 131.825 31.595 17.589 1.00 58.72 ? 15 GLY A CA 1 ATOM 87 C C . GLY A 1 15 ? 131.517 33.070 17.614 1.00 59.41 ? 15 GLY A C 1 ATOM 88 O O . GLY A 1 15 ? 131.261 33.695 16.572 1.00 60.13 ? 15 GLY A O 1 ATOM 89 N N . MET A 1 16 ? 131.544 33.623 18.813 1.00 58.90 ? 16 MET A N 1 ATOM 90 C CA . MET A 1 16 ? 131.176 34.989 19.048 1.00 59.70 ? 16 MET A CA 1 ATOM 91 C C . MET A 1 16 ? 132.004 35.497 20.224 1.00 58.92 ? 16 MET A C 1 ATOM 92 O O . MET A 1 16 ? 132.306 34.737 21.127 1.00 59.34 ? 16 MET A O 1 ATOM 93 C CB . MET A 1 16 ? 129.657 35.093 19.336 1.00 60.58 ? 16 MET A CB 1 ATOM 94 C CG . MET A 1 16 ? 129.179 34.542 20.691 1.00 62.78 ? 16 MET A CG 1 ATOM 95 S SD . MET A 1 16 ? 127.383 34.412 20.776 1.00 69.23 ? 16 MET A SD 1 ATOM 96 C CE . MET A 1 16 ? 126.955 36.135 21.091 1.00 70.46 ? 16 MET A CE 1 ATOM 97 N N . GLN A 1 17 ? 132.362 36.772 20.219 1.00 58.30 ? 17 GLN A N 1 ATOM 98 C CA . GLN A 1 17 ? 133.199 37.332 21.272 1.00 57.84 ? 17 GLN A CA 1 ATOM 99 C C . GLN A 1 17 ? 132.359 37.864 22.402 1.00 56.29 ? 17 GLN A C 1 ATOM 100 O O . GLN A 1 17 ? 131.340 38.497 22.174 1.00 55.75 ? 17 GLN A O 1 ATOM 101 C CB . GLN A 1 17 ? 134.055 38.458 20.714 1.00 58.82 ? 17 GLN A CB 1 ATOM 102 C CG . GLN A 1 17 ? 134.941 38.000 19.597 1.00 62.67 ? 17 GLN A CG 1 ATOM 103 C CD . GLN A 1 17 ? 136.269 37.443 20.104 1.00 67.79 ? 17 GLN A CD 1 ATOM 104 O OE1 . GLN A 1 17 ? 137.292 38.141 20.041 1.00 68.96 ? 17 GLN A OE1 1 ATOM 105 N NE2 . GLN A 1 17 ? 136.260 36.202 20.603 1.00 67.43 ? 17 GLN A NE2 1 ATOM 106 N N . LEU A 1 18 ? 132.792 37.617 23.627 1.00 55.23 ? 18 LEU A N 1 ATOM 107 C CA . LEU A 1 18 ? 132.040 38.107 24.777 1.00 55.37 ? 18 LEU A CA 1 ATOM 108 C C . LEU A 1 18 ? 132.913 38.897 25.706 1.00 54.91 ? 18 LEU A C 1 ATOM 109 O O . LEU A 1 18 ? 134.057 38.553 25.961 1.00 55.69 ? 18 LEU A O 1 ATOM 110 C CB . LEU A 1 18 ? 131.312 36.968 25.536 1.00 54.67 ? 18 LEU A CB 1 ATOM 111 C CG . LEU A 1 18 ? 130.481 35.941 24.743 1.00 54.77 ? 18 LEU A CG 1 ATOM 112 C CD1 . LEU A 1 18 ? 130.086 34.739 25.632 1.00 51.59 ? 18 LEU A CD1 1 ATOM 113 C CD2 . LEU A 1 18 ? 129.229 36.572 24.080 1.00 52.44 ? 18 LEU A CD2 1 ATOM 114 N N . THR A 1 19 ? 132.355 39.977 26.202 1.00 55.25 ? 19 THR A N 1 ATOM 115 C CA . THR A 1 19 ? 133.042 40.844 27.142 1.00 55.62 ? 19 THR A CA 1 ATOM 116 C C . THR A 1 19 ? 132.640 40.449 28.535 1.00 55.15 ? 19 THR A C 1 ATOM 117 O O . THR A 1 19 ? 131.466 40.542 28.935 1.00 54.83 ? 19 THR A O 1 ATOM 118 C CB . THR A 1 19 ? 132.750 42.339 26.836 1.00 55.39 ? 19 THR A CB 1 ATOM 119 O OG1 . THR A 1 19 ? 133.737 42.767 25.916 1.00 57.56 ? 19 THR A OG1 1 ATOM 120 C CG2 . THR A 1 19 ? 133.062 43.249 28.026 1.00 56.58 ? 19 THR A CG2 1 ATOM 121 N N . VAL A 1 20 ? 133.637 39.958 29.254 1.00 54.67 ? 20 VAL A N 1 ATOM 122 C CA . VAL A 1 20 ? 133.441 39.504 30.619 1.00 54.09 ? 20 VAL A CA 1 ATOM 123 C C . VAL A 1 20 ? 134.590 40.072 31.410 1.00 53.59 ? 20 VAL A C 1 ATOM 124 O O . VAL A 1 20 ? 135.748 39.766 31.117 1.00 53.18 ? 20 VAL A O 1 ATOM 125 C CB . VAL A 1 20 ? 133.472 37.936 30.735 1.00 53.63 ? 20 VAL A CB 1 ATOM 126 C CG1 . VAL A 1 20 ? 133.005 37.502 32.109 1.00 53.51 ? 20 VAL A CG1 1 ATOM 127 C CG2 . VAL A 1 20 ? 132.663 37.271 29.626 1.00 52.06 ? 20 VAL A CG2 1 ATOM 128 N N . PHE A 1 21 ? 134.267 40.880 32.412 1.00 53.33 ? 21 PHE A N 1 ATOM 129 C CA . PHE A 1 21 ? 135.251 41.365 33.380 1.00 54.06 ? 21 PHE A CA 1 ATOM 130 C C . PHE A 1 21 ? 136.466 42.020 32.721 1.00 54.29 ? 21 PHE A C 1 ATOM 131 O O . PHE A 1 21 ? 137.611 41.662 33.018 1.00 54.81 ? 21 PHE A O 1 ATOM 132 C CB . PHE A 1 21 ? 135.737 40.239 34.304 1.00 53.87 ? 21 PHE A CB 1 ATOM 133 C CG . PHE A 1 21 ? 134.634 39.532 35.088 1.00 54.83 ? 21 PHE A CG 1 ATOM 134 C CD1 . PHE A 1 21 ? 134.788 38.179 35.440 1.00 52.94 ? 21 PHE A CD1 1 ATOM 135 C CD2 . PHE A 1 21 ? 133.471 40.210 35.478 1.00 54.07 ? 21 PHE A CD2 1 ATOM 136 C CE1 . PHE A 1 21 ? 133.808 37.505 36.165 1.00 54.03 ? 21 PHE A CE1 1 ATOM 137 C CE2 . PHE A 1 21 ? 132.463 39.545 36.207 1.00 54.54 ? 21 PHE A CE2 1 ATOM 138 C CZ . PHE A 1 21 ? 132.638 38.184 36.554 1.00 53.71 ? 21 PHE A CZ 1 ATOM 139 N N . GLY A 1 22 ? 136.217 42.967 31.826 1.00 54.13 ? 22 GLY A N 1 ATOM 140 C CA . GLY A 1 22 ? 137.286 43.716 31.169 1.00 54.02 ? 22 GLY A CA 1 ATOM 141 C C . GLY A 1 22 ? 138.197 42.835 30.345 1.00 54.07 ? 22 GLY A C 1 ATOM 142 O O . GLY A 1 22 ? 139.359 43.186 30.077 1.00 54.31 ? 22 GLY A O 1 ATOM 143 N N . GLY A 1 23 ? 137.671 41.682 29.938 1.00 53.58 ? 23 GLY A N 1 ATOM 144 C CA . GLY A 1 23 ? 138.454 40.695 29.185 1.00 52.74 ? 23 GLY A CA 1 ATOM 145 C C . GLY A 1 23 ? 137.525 40.165 28.111 1.00 52.67 ? 23 GLY A C 1 ATOM 146 O O . GLY A 1 23 ? 136.417 40.659 27.967 1.00 52.55 ? 23 GLY A O 1 ATOM 147 N N . THR A 1 24 ? 137.971 39.164 27.361 1.00 52.29 ? 24 THR A N 1 ATOM 148 C CA . THR A 1 24 ? 137.152 38.547 26.346 1.00 51.80 ? 24 THR A CA 1 ATOM 149 C C . THR A 1 24 ? 137.070 37.046 26.585 1.00 51.08 ? 24 THR A C 1 ATOM 150 O O . THR A 1 24 ? 138.096 36.390 26.832 1.00 51.44 ? 24 THR A O 1 ATOM 151 C CB . THR A 1 24 ? 137.731 38.843 24.945 1.00 52.29 ? 24 THR A CB 1 ATOM 152 O OG1 . THR A 1 24 ? 137.546 40.240 24.653 1.00 56.49 ? 24 THR A OG1 1 ATOM 153 C CG2 . THR A 1 24 ? 136.917 38.171 23.851 1.00 50.34 ? 24 THR A CG2 1 ATOM 154 N N . VAL A 1 25 ? 135.860 36.500 26.495 1.00 49.46 ? 25 VAL A N 1 ATOM 155 C CA . VAL A 1 25 ? 135.701 35.061 26.268 1.00 48.50 ? 25 VAL A CA 1 ATOM 156 C C . VAL A 1 25 ? 135.123 34.807 24.880 1.00 48.00 ? 25 VAL A C 1 ATOM 157 O O . VAL A 1 25 ? 134.270 35.555 24.440 1.00 47.47 ? 25 VAL A O 1 ATOM 158 C CB . VAL A 1 25 ? 134.761 34.426 27.332 1.00 48.54 ? 25 VAL A CB 1 ATOM 159 C CG1 . VAL A 1 25 ? 134.508 32.958 27.037 1.00 46.01 ? 25 VAL A CG1 1 ATOM 160 C CG2 . VAL A 1 25 ? 135.345 34.614 28.715 1.00 47.19 ? 25 VAL A CG2 1 ATOM 161 N N . THR A 1 26 ? 135.558 33.730 24.223 1.00 47.70 ? 26 THR A N 1 ATOM 162 C CA . THR A 1 26 ? 134.921 33.239 23.003 1.00 47.70 ? 26 THR A CA 1 ATOM 163 C C . THR A 1 26 ? 133.944 32.049 23.249 1.00 48.37 ? 26 THR A C 1 ATOM 164 O O . THR A 1 26 ? 134.330 31.017 23.818 1.00 48.15 ? 26 THR A O 1 ATOM 165 C CB . THR A 1 26 ? 136.017 32.780 22.035 1.00 48.08 ? 26 THR A CB 1 ATOM 166 O OG1 . THR A 1 26 ? 137.008 33.802 21.931 1.00 48.43 ? 26 THR A OG1 1 ATOM 167 C CG2 . THR A 1 26 ? 135.490 32.584 20.640 1.00 46.37 ? 26 THR A CG2 1 ATOM 168 N N . ALA A 1 27 ? 132.691 32.190 22.781 1.00 48.52 ? 27 ALA A N 1 ATOM 169 C CA . ALA A 1 27 ? 131.632 31.204 23.013 1.00 47.68 ? 27 ALA A CA 1 ATOM 170 C C . ALA A 1 27 ? 131.220 30.595 21.702 1.00 48.20 ? 27 ALA A C 1 ATOM 171 O O . ALA A 1 27 ? 131.044 31.315 20.693 1.00 47.72 ? 27 ALA A O 1 ATOM 172 C CB . ALA A 1 27 ? 130.433 31.860 23.687 1.00 47.58 ? 27 ALA A CB 1 ATOM 173 N N . PHE A 1 28 ? 131.102 29.273 21.713 1.00 47.12 ? 28 PHE A N 1 ATOM 174 C CA . PHE A 1 28 ? 130.592 28.540 20.578 1.00 47.95 ? 28 PHE A CA 1 ATOM 175 C C . PHE A 1 28 ? 129.353 27.853 21.106 1.00 47.36 ? 28 PHE A C 1 ATOM 176 O O . PHE A 1 28 ? 129.465 26.810 21.763 1.00 48.11 ? 28 PHE A O 1 ATOM 177 C CB . PHE A 1 28 ? 131.597 27.499 20.028 1.00 47.69 ? 28 PHE A CB 1 ATOM 178 C CG . PHE A 1 28 ? 132.825 28.105 19.360 1.00 49.68 ? 28 PHE A CG 1 ATOM 179 C CD1 . PHE A 1 28 ? 133.918 28.537 20.133 1.00 49.46 ? 28 PHE A CD1 1 ATOM 180 C CD2 . PHE A 1 28 ? 132.895 28.219 17.954 1.00 48.54 ? 28 PHE A CD2 1 ATOM 181 C CE1 . PHE A 1 28 ? 135.041 29.113 19.539 1.00 49.41 ? 28 PHE A CE1 1 ATOM 182 C CE2 . PHE A 1 28 ? 134.003 28.759 17.342 1.00 49.40 ? 28 PHE A CE2 1 ATOM 183 C CZ . PHE A 1 28 ? 135.096 29.221 18.136 1.00 51.98 ? 28 PHE A CZ 1 ATOM 184 N N . LEU A 1 29 ? 128.199 28.479 20.854 1.00 45.97 ? 29 LEU A N 1 ATOM 185 C CA . LEU A 1 29 ? 126.928 28.063 21.395 1.00 45.15 ? 29 LEU A CA 1 ATOM 186 C C . LEU A 1 29 ? 126.160 27.272 20.349 1.00 45.10 ? 29 LEU A C 1 ATOM 187 O O . LEU A 1 29 ? 125.985 27.736 19.207 1.00 45.58 ? 29 LEU A O 1 ATOM 188 C CB . LEU A 1 29 ? 126.112 29.275 21.880 1.00 44.44 ? 29 LEU A CB 1 ATOM 189 C CG . LEU A 1 29 ? 126.657 30.225 22.951 1.00 42.98 ? 29 LEU A CG 1 ATOM 190 C CD1 . LEU A 1 29 ? 125.598 31.235 23.392 1.00 39.18 ? 29 LEU A CD1 1 ATOM 191 C CD2 . LEU A 1 29 ? 127.218 29.478 24.192 1.00 43.93 ? 29 LEU A CD2 1 ATOM 192 N N . GLY A 1 30 ? 125.737 26.056 20.719 1.00 45.06 ? 30 GLY A N 1 ATOM 193 C CA . GLY A 1 30 ? 124.988 25.158 19.828 1.00 44.04 ? 30 GLY A CA 1 ATOM 194 C C . GLY A 1 30 ? 125.744 24.482 18.698 1.00 45.83 ? 30 GLY A C 1 ATOM 195 O O . GLY A 1 30 ? 125.274 24.495 17.533 1.00 46.34 ? 30 GLY A O 1 ATOM 196 N N . ILE A 1 31 ? 126.901 23.874 19.001 1.00 44.87 ? 31 ILE A N 1 ATOM 197 C CA . ILE A 1 31 ? 127.558 22.979 18.048 1.00 44.68 ? 31 ILE A CA 1 ATOM 198 C C . ILE A 1 31 ? 126.855 21.602 18.052 1.00 44.87 ? 31 ILE A C 1 ATOM 199 O O . ILE A 1 31 ? 126.638 21.024 19.115 1.00 44.68 ? 31 ILE A O 1 ATOM 200 C CB . ILE A 1 31 ? 129.092 22.813 18.377 1.00 45.24 ? 31 ILE A CB 1 ATOM 201 C CG1 . ILE A 1 31 ? 129.766 24.163 18.635 1.00 45.21 ? 31 ILE A CG1 1 ATOM 202 C CG2 . ILE A 1 31 ? 129.852 22.003 17.275 1.00 45.25 ? 31 ILE A CG2 1 ATOM 203 C CD1 . ILE A 1 31 ? 131.105 24.028 19.428 1.00 50.05 ? 31 ILE A CD1 1 ATOM 204 N N . PRO A 1 32 ? 126.514 21.059 16.879 1.00 45.31 ? 32 PRO A N 1 ATOM 205 C CA . PRO A 1 32 ? 125.894 19.742 16.840 1.00 45.35 ? 32 PRO A CA 1 ATOM 206 C C . PRO A 1 32 ? 126.920 18.619 17.140 1.00 46.53 ? 32 PRO A C 1 ATOM 207 O O . PRO A 1 32 ? 128.105 18.772 16.866 1.00 46.70 ? 32 PRO A O 1 ATOM 208 C CB . PRO A 1 32 ? 125.343 19.638 15.409 1.00 45.31 ? 32 PRO A CB 1 ATOM 209 C CG . PRO A 1 32 ? 126.248 20.607 14.561 1.00 45.38 ? 32 PRO A CG 1 ATOM 210 C CD . PRO A 1 32 ? 126.709 21.656 15.527 1.00 44.79 ? 32 PRO A CD 1 ATOM 211 N N . TYR A 1 33 ? 126.459 17.496 17.692 1.00 46.51 ? 33 TYR A N 1 ATOM 212 C CA . TYR A 1 33 ? 127.381 16.413 18.028 1.00 47.03 ? 33 TYR A CA 1 ATOM 213 C C . TYR A 1 33 ? 126.838 15.036 17.626 1.00 47.49 ? 33 TYR A C 1 ATOM 214 O O . TYR A 1 33 ? 127.527 14.037 17.766 1.00 48.37 ? 33 TYR A O 1 ATOM 215 C CB . TYR A 1 33 ? 127.865 16.487 19.509 1.00 45.87 ? 33 TYR A CB 1 ATOM 216 C CG . TYR A 1 33 ? 126.843 16.111 20.598 1.00 43.68 ? 33 TYR A CG 1 ATOM 217 C CD1 . TYR A 1 33 ? 126.088 17.097 21.261 1.00 39.86 ? 33 TYR A CD1 1 ATOM 218 C CD2 . TYR A 1 33 ? 126.686 14.791 20.992 1.00 38.56 ? 33 TYR A CD2 1 ATOM 219 C CE1 . TYR A 1 33 ? 125.172 16.764 22.268 1.00 37.50 ? 33 TYR A CE1 1 ATOM 220 C CE2 . TYR A 1 33 ? 125.750 14.436 21.985 1.00 40.77 ? 33 TYR A CE2 1 ATOM 221 C CZ . TYR A 1 33 ? 125.007 15.432 22.623 1.00 40.09 ? 33 TYR A CZ 1 ATOM 222 O OH . TYR A 1 33 ? 124.131 15.078 23.617 1.00 38.99 ? 33 TYR A OH 1 ATOM 223 N N . ALA A 1 34 ? 125.628 15.000 17.068 1.00 47.66 ? 34 ALA A N 1 ATOM 224 C CA . ALA A 1 34 ? 125.033 13.748 16.594 1.00 47.35 ? 34 ALA A CA 1 ATOM 225 C C . ALA A 1 34 ? 123.961 14.028 15.540 1.00 47.63 ? 34 ALA A C 1 ATOM 226 O O . ALA A 1 34 ? 123.459 15.149 15.446 1.00 47.59 ? 34 ALA A O 1 ATOM 227 C CB . ALA A 1 34 ? 124.414 12.972 17.783 1.00 46.72 ? 34 ALA A CB 1 ATOM 228 N N A GLN A 1 35 ? 123.610 13.013 14.746 0.50 48.03 ? 35 GLN A N 1 ATOM 229 N N B GLN A 1 35 ? 123.606 13.001 14.774 0.50 47.68 ? 35 GLN A N 1 ATOM 230 C CA A GLN A 1 35 ? 122.414 13.093 13.913 0.50 48.52 ? 35 GLN A CA 1 ATOM 231 C CA B GLN A 1 35 ? 122.422 13.040 13.937 0.50 47.80 ? 35 GLN A CA 1 ATOM 232 C C A GLN A 1 35 ? 121.244 13.411 14.826 0.50 48.38 ? 35 GLN A C 1 ATOM 233 C C B GLN A 1 35 ? 121.237 13.399 14.833 0.50 48.04 ? 35 GLN A C 1 ATOM 234 O O A GLN A 1 35 ? 121.119 12.805 15.899 0.50 48.54 ? 35 GLN A O 1 ATOM 235 O O B GLN A 1 35 ? 121.098 12.808 15.912 0.50 48.17 ? 35 GLN A O 1 ATOM 236 C CB A GLN A 1 35 ? 122.134 11.787 13.161 0.50 48.57 ? 35 GLN A CB 1 ATOM 237 C CB B GLN A 1 35 ? 122.190 11.675 13.289 0.50 47.57 ? 35 GLN A CB 1 ATOM 238 C CG A GLN A 1 35 ? 122.449 11.835 11.658 0.50 50.13 ? 35 GLN A CG 1 ATOM 239 C CG B GLN A 1 35 ? 123.407 11.128 12.535 0.50 46.96 ? 35 GLN A CG 1 ATOM 240 C CD A GLN A 1 35 ? 121.377 12.541 10.806 0.50 52.47 ? 35 GLN A CD 1 ATOM 241 C CD B GLN A 1 35 ? 123.113 9.844 11.741 0.50 47.82 ? 35 GLN A CD 1 ATOM 242 O OE1 A GLN A 1 35 ? 120.238 12.054 10.668 0.50 50.17 ? 35 GLN A OE1 1 ATOM 243 O OE1 B GLN A 1 35 ? 124.040 9.056 11.436 0.50 47.55 ? 35 GLN A OE1 1 ATOM 244 N NE2 A GLN A 1 35 ? 121.765 13.670 10.193 0.50 53.19 ? 35 GLN A NE2 1 ATOM 245 N NE2 B GLN A 1 35 ? 121.838 9.639 11.388 0.50 45.22 ? 35 GLN A NE2 1 ATOM 246 N N . PRO A 1 36 ? 120.397 14.360 14.422 1.00 48.08 ? 36 PRO A N 1 ATOM 247 C CA . PRO A 1 36 ? 119.192 14.676 15.195 1.00 47.85 ? 36 PRO A CA 1 ATOM 248 C C . PRO A 1 36 ? 118.409 13.357 15.356 1.00 47.42 ? 36 PRO A C 1 ATOM 249 O O . PRO A 1 36 ? 118.294 12.610 14.406 1.00 48.17 ? 36 PRO A O 1 ATOM 250 C CB . PRO A 1 36 ? 118.479 15.724 14.328 1.00 47.61 ? 36 PRO A CB 1 ATOM 251 C CG . PRO A 1 36 ? 119.572 16.351 13.520 1.00 47.38 ? 36 PRO A CG 1 ATOM 252 C CD . PRO A 1 36 ? 120.517 15.213 13.218 1.00 47.99 ? 36 PRO A CD 1 ATOM 253 N N . PRO A 1 37 ? 117.997 12.997 16.562 1.00 47.62 ? 37 PRO A N 1 ATOM 254 C CA . PRO A 1 37 ? 117.398 11.686 16.766 1.00 47.91 ? 37 PRO A CA 1 ATOM 255 C C . PRO A 1 37 ? 115.900 11.681 16.467 1.00 49.16 ? 37 PRO A C 1 ATOM 256 O O . PRO A 1 37 ? 115.076 11.490 17.366 1.00 48.86 ? 37 PRO A O 1 ATOM 257 C CB . PRO A 1 37 ? 117.693 11.403 18.229 1.00 47.84 ? 37 PRO A CB 1 ATOM 258 C CG . PRO A 1 37 ? 117.625 12.808 18.880 1.00 48.39 ? 37 PRO A CG 1 ATOM 259 C CD . PRO A 1 37 ? 118.107 13.775 17.813 1.00 46.98 ? 37 PRO A CD 1 ATOM 260 N N . LEU A 1 38 ? 115.576 11.891 15.191 1.00 50.73 ? 38 LEU A N 1 ATOM 261 C CA . LEU A 1 38 ? 114.199 12.048 14.706 1.00 51.81 ? 38 LEU A CA 1 ATOM 262 C C . LEU A 1 38 ? 113.734 10.886 13.829 1.00 52.57 ? 38 LEU A C 1 ATOM 263 O O . LEU A 1 38 ? 114.536 10.169 13.237 1.00 53.42 ? 38 LEU A O 1 ATOM 264 C CB . LEU A 1 38 ? 114.074 13.342 13.926 1.00 51.84 ? 38 LEU A CB 1 ATOM 265 C CG . LEU A 1 38 ? 114.828 14.524 14.490 1.00 52.80 ? 38 LEU A CG 1 ATOM 266 C CD1 . LEU A 1 38 ? 115.188 15.490 13.352 1.00 54.24 ? 38 LEU A CD1 1 ATOM 267 C CD2 . LEU A 1 38 ? 113.998 15.207 15.604 1.00 53.60 ? 38 LEU A CD2 1 ATOM 268 N N . GLY A 1 39 ? 112.419 10.697 13.764 1.00 53.60 ? 39 GLY A N 1 ATOM 269 C CA . GLY A 1 39 ? 111.831 9.636 12.953 1.00 53.19 ? 39 GLY A CA 1 ATOM 270 C C . GLY A 1 39 ? 112.095 8.219 13.425 1.00 53.19 ? 39 GLY A C 1 ATOM 271 O O . GLY A 1 39 ? 111.516 7.748 14.389 1.00 54.09 ? 39 GLY A O 1 ATOM 272 N N . ARG A 1 40 ? 112.941 7.510 12.705 1.00 53.40 ? 40 ARG A N 1 ATOM 273 C CA . ARG A 1 40 ? 113.323 6.156 13.088 1.00 52.95 ? 40 ARG A CA 1 ATOM 274 C C . ARG A 1 40 ? 114.459 6.098 14.145 1.00 52.51 ? 40 ARG A C 1 ATOM 275 O O . ARG A 1 40 ? 114.652 5.047 14.784 1.00 52.87 ? 40 ARG A O 1 ATOM 276 C CB . ARG A 1 40 ? 113.691 5.348 11.847 1.00 53.52 ? 40 ARG A CB 1 ATOM 277 C CG . ARG A 1 40 ? 114.900 5.847 10.995 1.00 55.03 ? 40 ARG A CG 1 ATOM 278 C CD . ARG A 1 40 ? 115.493 4.700 10.102 1.00 56.84 ? 40 ARG A CD 1 ATOM 279 N NE . ARG A 1 40 ? 114.491 3.652 9.842 0.20 56.52 ? 40 ARG A NE 1 ATOM 280 C CZ . ARG A 1 40 ? 114.314 2.551 10.585 0.20 56.79 ? 40 ARG A CZ 1 ATOM 281 N NH1 . ARG A 1 40 ? 115.074 2.315 11.649 0.20 57.31 ? 40 ARG A NH1 1 ATOM 282 N NH2 . ARG A 1 40 ? 113.367 1.682 10.265 0.20 55.74 ? 40 ARG A NH2 1 ATOM 283 N N . LEU A 1 41 ? 115.180 7.224 14.308 1.00 50.41 ? 41 LEU A N 1 ATOM 284 C CA . LEU A 1 41 ? 116.167 7.409 15.372 1.00 48.84 ? 41 LEU A CA 1 ATOM 285 C C . LEU A 1 41 ? 115.567 7.754 16.732 1.00 49.00 ? 41 LEU A C 1 ATOM 286 O O . LEU A 1 41 ? 116.298 7.700 17.739 1.00 50.29 ? 41 LEU A O 1 ATOM 287 C CB . LEU A 1 41 ? 117.215 8.454 14.979 1.00 48.25 ? 41 LEU A CB 1 ATOM 288 C CG . LEU A 1 41 ? 117.909 8.267 13.632 1.00 47.73 ? 41 LEU A CG 1 ATOM 289 C CD1 . LEU A 1 41 ? 118.975 9.288 13.445 1.00 48.14 ? 41 LEU A CD1 1 ATOM 290 C CD2 . LEU A 1 41 ? 118.460 6.816 13.502 1.00 45.01 ? 41 LEU A CD2 1 ATOM 291 N N . ARG A 1 42 ? 114.278 8.116 16.792 1.00 47.20 ? 42 ARG A N 1 ATOM 292 C CA . ARG A 1 42 ? 113.642 8.320 18.073 1.00 46.16 ? 42 ARG A CA 1 ATOM 293 C C . ARG A 1 42 ? 113.792 7.035 18.876 1.00 46.88 ? 42 ARG A C 1 ATOM 294 O O . ARG A 1 42 ? 113.505 5.946 18.345 1.00 47.37 ? 42 ARG A O 1 ATOM 295 C CB . ARG A 1 42 ? 112.157 8.661 17.928 1.00 45.51 ? 42 ARG A CB 1 ATOM 296 C CG . ARG A 1 42 ? 111.505 8.901 19.260 1.00 43.22 ? 42 ARG A CG 1 ATOM 297 C CD . ARG A 1 42 ? 110.027 9.051 19.242 1.00 40.58 ? 42 ARG A CD 1 ATOM 298 N NE . ARG A 1 42 ? 109.616 10.388 18.846 1.00 37.44 ? 42 ARG A NE 1 ATOM 299 C CZ . ARG A 1 42 ? 108.365 10.743 18.621 1.00 36.34 ? 42 ARG A CZ 1 ATOM 300 N NH1 . ARG A 1 42 ? 107.377 9.877 18.784 1.00 37.02 ? 42 ARG A NH1 1 ATOM 301 N NH2 . ARG A 1 42 ? 108.103 11.978 18.245 1.00 37.68 ? 42 ARG A NH2 1 ATOM 302 N N . PHE A 1 43 ? 114.254 7.161 20.130 1.00 46.72 ? 43 PHE A N 1 ATOM 303 C CA . PHE A 1 43 ? 114.477 6.019 21.061 1.00 46.88 ? 43 PHE A CA 1 ATOM 304 C C . PHE A 1 43 ? 115.787 5.247 20.861 1.00 46.93 ? 43 PHE A C 1 ATOM 305 O O . PHE A 1 43 ? 116.144 4.383 21.657 1.00 46.37 ? 43 PHE A O 1 ATOM 306 C CB . PHE A 1 43 ? 113.282 5.056 21.104 1.00 46.70 ? 43 PHE A CB 1 ATOM 307 C CG . PHE A 1 43 ? 111.981 5.693 21.575 1.00 47.65 ? 43 PHE A CG 1 ATOM 308 C CD1 . PHE A 1 43 ? 111.913 6.385 22.788 1.00 48.44 ? 43 PHE A CD1 1 ATOM 309 C CD2 . PHE A 1 43 ? 110.814 5.567 20.817 1.00 46.53 ? 43 PHE A CD2 1 ATOM 310 C CE1 . PHE A 1 43 ? 110.688 6.963 23.215 1.00 48.67 ? 43 PHE A CE1 1 ATOM 311 C CE2 . PHE A 1 43 ? 109.622 6.120 21.226 1.00 43.83 ? 43 PHE A CE2 1 ATOM 312 C CZ . PHE A 1 43 ? 109.539 6.812 22.420 1.00 44.99 ? 43 PHE A CZ 1 ATOM 313 N N . LYS A 1 44 ? 116.526 5.586 19.817 1.00 47.38 ? 44 LYS A N 1 ATOM 314 C CA . LYS A 1 44 ? 117.778 4.917 19.587 1.00 48.69 ? 44 LYS A CA 1 ATOM 315 C C . LYS A 1 44 ? 118.957 5.701 20.174 1.00 48.87 ? 44 LYS A C 1 ATOM 316 O O . LYS A 1 44 ? 118.858 6.903 20.478 1.00 48.87 ? 44 LYS A O 1 ATOM 317 C CB . LYS A 1 44 ? 118.010 4.665 18.089 1.00 49.08 ? 44 LYS A CB 1 ATOM 318 C CG . LYS A 1 44 ? 117.010 3.701 17.392 1.00 52.14 ? 44 LYS A CG 1 ATOM 319 C CD . LYS A 1 44 ? 117.573 3.312 16.012 1.00 57.19 ? 44 LYS A CD 1 ATOM 320 C CE . LYS A 1 44 ? 116.896 2.091 15.401 1.00 61.52 ? 44 LYS A CE 1 ATOM 321 N NZ . LYS A 1 44 ? 115.610 2.439 14.667 1.00 63.33 ? 44 LYS A NZ 1 ATOM 322 N N . LYS A 1 45 ? 120.078 4.994 20.291 1.00 48.53 ? 45 LYS A N 1 ATOM 323 C CA . LYS A 1 45 ? 121.335 5.550 20.715 1.00 49.35 ? 45 LYS A CA 1 ATOM 324 C C . LYS A 1 45 ? 121.723 6.595 19.662 1.00 49.43 ? 45 LYS A C 1 ATOM 325 O O . LYS A 1 45 ? 121.342 6.447 18.506 1.00 49.09 ? 45 LYS A O 1 ATOM 326 C CB . LYS A 1 45 ? 122.416 4.430 20.866 1.00 49.57 ? 45 LYS A CB 1 ATOM 327 C CG . LYS A 1 45 ? 122.110 3.453 21.984 1.00 49.17 ? 45 LYS A CG 1 ATOM 328 C CD . LYS A 1 45 ? 123.280 2.651 22.441 1.00 53.96 ? 45 LYS A CD 1 ATOM 329 C CE . LYS A 1 45 ? 124.317 2.391 21.373 1.00 55.88 ? 45 LYS A CE 1 ATOM 330 N NZ . LYS A 1 45 ? 125.349 1.405 21.912 1.00 56.39 ? 45 LYS A NZ 1 ATOM 331 N N . PRO A 1 46 ? 122.467 7.631 20.065 1.00 49.19 ? 46 PRO A N 1 ATOM 332 C CA . PRO A 1 46 ? 122.804 8.718 19.159 1.00 50.20 ? 46 PRO A CA 1 ATOM 333 C C . PRO A 1 46 ? 123.730 8.236 18.019 1.00 51.60 ? 46 PRO A C 1 ATOM 334 O O . PRO A 1 46 ? 124.620 7.440 18.241 1.00 51.96 ? 46 PRO A O 1 ATOM 335 C CB . PRO A 1 46 ? 123.494 9.762 20.078 1.00 49.73 ? 46 PRO A CB 1 ATOM 336 C CG . PRO A 1 46 ? 124.003 8.962 21.278 1.00 47.23 ? 46 PRO A CG 1 ATOM 337 C CD . PRO A 1 46 ? 123.062 7.799 21.409 1.00 48.25 ? 46 PRO A CD 1 ATOM 338 N N . GLN A 1 47 ? 123.510 8.723 16.813 1.00 53.69 ? 47 GLN A N 1 ATOM 339 C CA . GLN A 1 47 ? 124.245 8.237 15.656 1.00 55.56 ? 47 GLN A CA 1 ATOM 340 C C . GLN A 1 47 ? 125.169 9.342 15.233 1.00 56.75 ? 47 GLN A C 1 ATOM 341 O O . GLN A 1 47 ? 124.912 10.508 15.525 1.00 55.95 ? 47 GLN A O 1 ATOM 342 C CB . GLN A 1 47 ? 123.279 7.840 14.545 1.00 55.26 ? 47 GLN A CB 1 ATOM 343 C CG . GLN A 1 47 ? 122.103 6.959 15.033 1.00 58.47 ? 47 GLN A CG 1 ATOM 344 C CD . GLN A 1 47 ? 122.483 5.510 15.301 1.00 61.88 ? 47 GLN A CD 1 ATOM 345 O OE1 . GLN A 1 47 ? 123.442 5.009 14.710 1.00 65.57 ? 47 GLN A OE1 1 ATOM 346 N NE2 . GLN A 1 47 ? 121.738 4.829 16.194 1.00 59.96 ? 47 GLN A NE2 1 ATOM 347 N N . SER A 1 48 ? 126.271 8.990 14.580 1.00 59.67 ? 48 SER A N 1 ATOM 348 C CA . SER A 1 48 ? 127.358 9.969 14.393 1.00 62.65 ? 48 SER A CA 1 ATOM 349 C C . SER A 1 48 ? 127.038 10.939 13.263 1.00 63.98 ? 48 SER A C 1 ATOM 350 O O . SER A 1 48 ? 126.293 10.606 12.351 1.00 63.99 ? 48 SER A O 1 ATOM 351 C CB . SER A 1 48 ? 128.732 9.292 14.220 1.00 63.04 ? 48 SER A CB 1 ATOM 352 O OG . SER A 1 48 ? 128.879 8.761 12.910 1.00 64.82 ? 48 SER A OG 1 ATOM 353 N N . LEU A 1 49 ? 127.595 12.140 13.345 1.00 66.32 ? 49 LEU A N 1 ATOM 354 C CA . LEU A 1 49 ? 127.220 13.217 12.434 1.00 68.47 ? 49 LEU A CA 1 ATOM 355 C C . LEU A 1 49 ? 128.045 13.258 11.138 1.00 69.97 ? 49 LEU A C 1 ATOM 356 O O . LEU A 1 49 ? 129.278 13.164 11.164 1.00 70.22 ? 49 LEU A O 1 ATOM 357 C CB . LEU A 1 49 ? 127.271 14.574 13.157 1.00 68.28 ? 49 LEU A CB 1 ATOM 358 C CG . LEU A 1 49 ? 126.513 15.710 12.468 1.00 68.81 ? 49 LEU A CG 1 ATOM 359 C CD1 . LEU A 1 49 ? 125.004 15.419 12.294 1.00 69.97 ? 49 LEU A CD1 1 ATOM 360 C CD2 . LEU A 1 49 ? 126.738 17.006 13.209 1.00 70.16 ? 49 LEU A CD2 1 ATOM 361 N N . THR A 1 50 ? 127.342 13.423 10.016 1.00 71.66 ? 50 THR A N 1 ATOM 362 C CA . THR A 1 50 ? 127.970 13.606 8.705 1.00 72.75 ? 50 THR A CA 1 ATOM 363 C C . THR A 1 50 ? 128.678 14.975 8.619 1.00 73.69 ? 50 THR A C 1 ATOM 364 O O . THR A 1 50 ? 128.167 15.990 9.125 1.00 73.33 ? 50 THR A O 1 ATOM 365 C CB . THR A 1 50 ? 126.913 13.377 7.563 0.50 72.86 ? 50 THR A CB 1 ATOM 366 O OG1 . THR A 1 50 ? 127.014 12.030 7.077 0.50 72.30 ? 50 THR A OG1 1 ATOM 367 C CG2 . THR A 1 50 ? 127.208 14.200 6.315 0.50 72.99 ? 50 THR A CG2 1 ATOM 368 N N . LYS A 1 51 ? 129.859 14.978 7.993 1.00 74.57 ? 51 LYS A N 1 ATOM 369 C CA . LYS A 1 51 ? 130.651 16.198 7.786 1.00 75.80 ? 51 LYS A CA 1 ATOM 370 C C . LYS A 1 51 ? 129.844 17.278 7.069 1.00 76.24 ? 51 LYS A C 1 ATOM 371 O O . LYS A 1 51 ? 128.898 16.961 6.364 1.00 76.69 ? 51 LYS A O 1 ATOM 372 C CB . LYS A 1 51 ? 131.955 15.891 7.014 0.50 75.84 ? 51 LYS A CB 1 ATOM 373 C CG . LYS A 1 51 ? 131.788 15.013 5.766 0.50 76.58 ? 51 LYS A CG 1 ATOM 374 C CD . LYS A 1 51 ? 132.956 15.137 4.780 0.50 78.13 ? 51 LYS A CD 1 ATOM 375 C CE . LYS A 1 51 ? 132.683 16.205 3.712 0.50 78.68 ? 51 LYS A CE 1 ATOM 376 N NZ . LYS A 1 51 ? 133.654 16.152 2.580 0.50 78.44 ? 51 LYS A NZ 1 ATOM 377 N N . TRP A 1 52 ? 130.210 18.549 7.260 1.00 77.08 ? 52 TRP A N 1 ATOM 378 C CA . TRP A 1 52 ? 129.555 19.664 6.551 1.00 77.40 ? 52 TRP A CA 1 ATOM 379 C C . TRP A 1 52 ? 130.547 20.658 5.939 1.00 78.04 ? 52 TRP A C 1 ATOM 380 O O . TRP A 1 52 ? 131.623 20.908 6.489 1.00 78.53 ? 52 TRP A O 1 ATOM 381 C CB . TRP A 1 52 ? 128.543 20.401 7.450 1.00 76.74 ? 52 TRP A CB 1 ATOM 382 C CG . TRP A 1 52 ? 129.164 21.149 8.587 1.00 75.94 ? 52 TRP A CG 1 ATOM 383 C CD1 . TRP A 1 52 ? 129.757 22.381 8.535 1.00 75.89 ? 52 TRP A CD1 1 ATOM 384 C CD2 . TRP A 1 52 ? 129.260 20.724 9.953 1.00 75.43 ? 52 TRP A CD2 1 ATOM 385 N NE1 . TRP A 1 52 ? 130.213 22.749 9.778 1.00 74.47 ? 52 TRP A NE1 1 ATOM 386 C CE2 . TRP A 1 52 ? 129.923 21.747 10.669 1.00 74.65 ? 52 TRP A CE2 1 ATOM 387 C CE3 . TRP A 1 52 ? 128.851 19.580 10.653 1.00 75.32 ? 52 TRP A CE3 1 ATOM 388 C CZ2 . TRP A 1 52 ? 130.190 21.655 12.038 1.00 73.96 ? 52 TRP A CZ2 1 ATOM 389 C CZ3 . TRP A 1 52 ? 129.106 19.501 12.018 1.00 74.61 ? 52 TRP A CZ3 1 ATOM 390 C CH2 . TRP A 1 52 ? 129.766 20.531 12.691 1.00 73.88 ? 52 TRP A CH2 1 ATOM 391 N N . SER A 1 53 ? 130.162 21.205 4.789 1.00 78.76 ? 53 SER A N 1 ATOM 392 C CA . SER A 1 53 ? 130.794 22.386 4.202 1.00 79.11 ? 53 SER A CA 1 ATOM 393 C C . SER A 1 53 ? 130.240 23.629 4.890 1.00 78.91 ? 53 SER A C 1 ATOM 394 O O . SER A 1 53 ? 129.442 23.532 5.821 1.00 78.87 ? 53 SER A O 1 ATOM 395 C CB . SER A 1 53 ? 130.499 22.472 2.692 1.00 79.50 ? 53 SER A CB 1 ATOM 396 O OG . SER A 1 53 ? 131.653 22.223 1.917 1.00 80.11 ? 53 SER A OG 1 ATOM 397 N N . ASP A 1 54 ? 130.648 24.795 4.399 1.00 78.61 ? 54 ASP A N 1 ATOM 398 C CA . ASP A 1 54 ? 130.239 26.080 4.953 1.00 78.25 ? 54 ASP A CA 1 ATOM 399 C C . ASP A 1 54 ? 130.651 26.159 6.427 1.00 76.76 ? 54 ASP A C 1 ATOM 400 O O . ASP A 1 54 ? 131.161 25.180 6.987 1.00 76.78 ? 54 ASP A O 1 ATOM 401 C CB . ASP A 1 54 ? 128.732 26.373 4.708 1.00 79.22 ? 54 ASP A CB 1 ATOM 402 C CG . ASP A 1 54 ? 127.796 25.744 5.775 1.00 82.27 ? 54 ASP A CG 1 ATOM 403 O OD1 . ASP A 1 54 ? 127.279 24.608 5.548 1.00 84.36 ? 54 ASP A OD1 1 ATOM 404 O OD2 . ASP A 1 54 ? 127.513 26.327 6.860 1.00 84.00 ? 54 ASP A OD2 1 ATOM 405 N N . ILE A 1 55 ? 130.472 27.333 7.026 1.00 74.60 ? 55 ILE A N 1 ATOM 406 C CA . ILE A 1 55 ? 130.767 27.542 8.426 1.00 72.47 ? 55 ILE A CA 1 ATOM 407 C C . ILE A 1 55 ? 129.472 27.405 9.235 1.00 70.94 ? 55 ILE A C 1 ATOM 408 O O . ILE A 1 55 ? 128.554 28.224 9.088 1.00 70.40 ? 55 ILE A O 1 ATOM 409 C CB . ILE A 1 55 ? 131.456 28.918 8.644 1.00 72.63 ? 55 ILE A CB 1 ATOM 410 C CG1 . ILE A 1 55 ? 132.906 28.884 8.122 1.00 72.84 ? 55 ILE A CG1 1 ATOM 411 C CG2 . ILE A 1 55 ? 131.424 29.320 10.125 1.00 72.83 ? 55 ILE A CG2 1 ATOM 412 C CD1 . ILE A 1 55 ? 133.597 30.268 7.967 1.00 71.57 ? 55 ILE A CD1 1 ATOM 413 N N . TRP A 1 56 ? 129.392 26.347 10.057 1.00 68.94 ? 56 TRP A N 1 ATOM 414 C CA . TRP A 1 56 ? 128.323 26.238 11.063 1.00 66.63 ? 56 TRP A CA 1 ATOM 415 C C . TRP A 1 56 ? 128.398 27.407 12.058 1.00 66.01 ? 56 TRP A C 1 ATOM 416 O O . TRP A 1 56 ? 129.413 27.621 12.721 1.00 66.14 ? 56 TRP A O 1 ATOM 417 C CB . TRP A 1 56 ? 128.342 24.904 11.819 1.00 66.12 ? 56 TRP A CB 1 ATOM 418 C CG . TRP A 1 56 ? 127.204 24.851 12.789 1.00 62.34 ? 56 TRP A CG 1 ATOM 419 C CD1 . TRP A 1 56 ? 127.044 25.611 13.908 1.00 58.14 ? 56 TRP A CD1 1 ATOM 420 C CD2 . TRP A 1 56 ? 126.031 24.059 12.671 1.00 59.88 ? 56 TRP A CD2 1 ATOM 421 N NE1 . TRP A 1 56 ? 125.847 25.324 14.511 1.00 57.85 ? 56 TRP A NE1 1 ATOM 422 C CE2 . TRP A 1 56 ? 125.202 24.371 13.770 1.00 58.43 ? 56 TRP A CE2 1 ATOM 423 C CE3 . TRP A 1 56 ? 125.602 23.088 11.758 1.00 60.43 ? 56 TRP A CE3 1 ATOM 424 C CZ2 . TRP A 1 56 ? 123.974 23.755 13.980 1.00 59.28 ? 56 TRP A CZ2 1 ATOM 425 C CZ3 . TRP A 1 56 ? 124.377 22.467 11.967 1.00 61.08 ? 56 TRP A CZ3 1 ATOM 426 C CH2 . TRP A 1 56 ? 123.574 22.808 13.069 1.00 60.26 ? 56 TRP A CH2 1 ATOM 427 N N . ASN A 1 57 ? 127.320 28.168 12.147 1.00 65.16 ? 57 ASN A N 1 ATOM 428 C CA . ASN A 1 57 ? 127.273 29.335 13.009 1.00 64.73 ? 57 ASN A CA 1 ATOM 429 C C . ASN A 1 57 ? 126.887 28.898 14.419 1.00 63.20 ? 57 ASN A C 1 ATOM 430 O O . ASN A 1 57 ? 125.751 28.513 14.641 1.00 63.80 ? 57 ASN A O 1 ATOM 431 C CB . ASN A 1 57 ? 126.265 30.351 12.443 1.00 65.81 ? 57 ASN A CB 1 ATOM 432 C CG . ASN A 1 57 ? 126.877 31.274 11.388 1.00 68.96 ? 57 ASN A CG 1 ATOM 433 O OD1 . ASN A 1 57 ? 128.105 31.493 11.372 1.00 70.06 ? 57 ASN A OD1 1 ATOM 434 N ND2 . ASN A 1 57 ? 126.016 31.846 10.519 1.00 74.34 ? 57 ASN A ND2 1 ATOM 435 N N . ALA A 1 58 ? 127.840 28.914 15.354 1.00 61.08 ? 58 ALA A N 1 ATOM 436 C CA . ALA A 1 58 ? 127.570 28.564 16.756 1.00 58.17 ? 58 ALA A CA 1 ATOM 437 C C . ALA A 1 58 ? 127.441 29.818 17.606 1.00 56.62 ? 58 ALA A C 1 ATOM 438 O O . ALA A 1 58 ? 128.248 30.065 18.501 1.00 56.16 ? 58 ALA A O 1 ATOM 439 C CB . ALA A 1 58 ? 128.643 27.639 17.309 1.00 58.11 ? 58 ALA A CB 1 ATOM 440 N N . THR A 1 59 ? 126.380 30.583 17.344 1.00 54.73 ? 59 THR A N 1 ATOM 441 C CA . THR A 1 59 ? 126.249 31.950 17.870 1.00 52.44 ? 59 THR A CA 1 ATOM 442 C C . THR A 1 59 ? 125.027 32.148 18.750 1.00 50.67 ? 59 THR A C 1 ATOM 443 O O . THR A 1 59 ? 124.732 33.260 19.208 1.00 50.56 ? 59 THR A O 1 ATOM 444 C CB . THR A 1 59 ? 126.284 32.954 16.700 1.00 52.97 ? 59 THR A CB 1 ATOM 445 O OG1 . THR A 1 59 ? 125.733 32.327 15.528 1.00 54.49 ? 59 THR A OG1 1 ATOM 446 C CG2 . THR A 1 59 ? 127.724 33.160 16.269 1.00 51.70 ? 59 THR A CG2 1 ATOM 447 N N . LYS A 1 60 ? 124.325 31.050 19.004 1.00 48.57 ? 60 LYS A N 1 ATOM 448 C CA . LYS A 1 60 ? 123.212 31.050 19.945 1.00 46.95 ? 60 LYS A CA 1 ATOM 449 C C . LYS A 1 60 ? 122.926 29.646 20.431 1.00 44.79 ? 60 LYS A C 1 ATOM 450 O O . LYS A 1 60 ? 123.204 28.693 19.741 1.00 42.41 ? 60 LYS A O 1 ATOM 451 C CB . LYS A 1 60 ? 121.946 31.676 19.331 1.00 47.34 ? 60 LYS A CB 1 ATOM 452 C CG . LYS A 1 60 ? 121.535 31.069 18.010 1.00 47.90 ? 60 LYS A CG 1 ATOM 453 C CD . LYS A 1 60 ? 120.616 32.020 17.222 0.20 48.19 ? 60 LYS A CD 1 ATOM 454 C CE . LYS A 1 60 ? 119.280 32.286 17.920 0.20 47.56 ? 60 LYS A CE 1 ATOM 455 N NZ . LYS A 1 60 ? 118.349 31.129 17.837 0.20 47.98 ? 60 LYS A NZ 1 ATOM 456 N N . TYR A 1 61 ? 122.401 29.554 21.648 1.00 43.30 ? 61 TYR A N 1 ATOM 457 C CA . TYR A 1 61 ? 121.998 28.263 22.223 1.00 43.44 ? 61 TYR A CA 1 ATOM 458 C C . TYR A 1 61 ? 121.005 27.545 21.312 1.00 42.58 ? 61 TYR A C 1 ATOM 459 O O . TYR A 1 61 ? 120.134 28.179 20.723 1.00 41.61 ? 61 TYR A O 1 ATOM 460 C CB . TYR A 1 61 ? 121.324 28.511 23.569 1.00 43.24 ? 61 TYR A CB 1 ATOM 461 C CG . TYR A 1 61 ? 122.227 28.989 24.687 1.00 44.31 ? 61 TYR A CG 1 ATOM 462 C CD1 . TYR A 1 61 ? 123.212 28.163 25.205 1.00 43.55 ? 61 TYR A CD1 1 ATOM 463 C CD2 . TYR A 1 61 ? 122.036 30.240 25.273 1.00 44.16 ? 61 TYR A CD2 1 ATOM 464 C CE1 . TYR A 1 61 ? 124.035 28.593 26.284 1.00 44.83 ? 61 TYR A CE1 1 ATOM 465 C CE2 . TYR A 1 61 ? 122.820 30.669 26.337 1.00 45.10 ? 61 TYR A CE2 1 ATOM 466 C CZ . TYR A 1 61 ? 123.824 29.836 26.837 1.00 45.58 ? 61 TYR A CZ 1 ATOM 467 O OH . TYR A 1 61 ? 124.587 30.244 27.905 1.00 45.24 ? 61 TYR A OH 1 ATOM 468 N N . ALA A 1 62 ? 121.129 26.238 21.203 1.00 41.93 ? 62 ALA A N 1 ATOM 469 C CA . ALA A 1 62 ? 120.248 25.482 20.315 1.00 41.96 ? 62 ALA A CA 1 ATOM 470 C C . ALA A 1 62 ? 118.967 25.097 21.054 1.00 42.34 ? 62 ALA A C 1 ATOM 471 O O . ALA A 1 62 ? 118.777 25.487 22.210 1.00 43.45 ? 62 ALA A O 1 ATOM 472 C CB . ALA A 1 62 ? 120.958 24.253 19.767 1.00 40.42 ? 62 ALA A CB 1 ATOM 473 N N . ASN A 1 63 ? 118.090 24.345 20.397 1.00 41.51 ? 63 ASN A N 1 ATOM 474 C CA . ASN A 1 63 ? 116.945 23.737 21.068 1.00 41.70 ? 63 ASN A CA 1 ATOM 475 C C . ASN A 1 63 ? 117.292 22.895 22.297 1.00 41.13 ? 63 ASN A C 1 ATOM 476 O O . ASN A 1 63 ? 118.266 22.146 22.294 1.00 39.76 ? 63 ASN A O 1 ATOM 477 C CB . ASN A 1 63 ? 116.200 22.785 20.126 1.00 42.34 ? 63 ASN A CB 1 ATOM 478 C CG . ASN A 1 63 ? 115.771 23.444 18.822 1.00 43.55 ? 63 ASN A CG 1 ATOM 479 O OD1 . ASN A 1 63 ? 115.523 24.663 18.753 1.00 44.84 ? 63 ASN A OD1 1 ATOM 480 N ND2 . ASN A 1 63 ? 115.670 22.631 17.782 1.00 44.30 ? 63 ASN A ND2 1 ATOM 481 N N . SER A 1 64 ? 116.445 23.012 23.319 1.00 40.71 ? 64 SER A N 1 ATOM 482 C CA . SER A 1 64 ? 116.430 22.109 24.457 1.00 40.10 ? 64 SER A CA 1 ATOM 483 C C . SER A 1 64 ? 115.590 20.877 24.047 1.00 41.56 ? 64 SER A C 1 ATOM 484 O O . SER A 1 64 ? 114.631 21.013 23.257 1.00 43.31 ? 64 SER A O 1 ATOM 485 C CB . SER A 1 64 ? 115.789 22.821 25.641 1.00 38.89 ? 64 SER A CB 1 ATOM 486 O OG . SER A 1 64 ? 116.471 24.011 25.992 1.00 36.89 ? 64 SER A OG 1 ATOM 487 N N . CYS A 1 65 ? 115.913 19.701 24.574 1.00 40.42 ? 65 CYS A N 1 ATOM 488 C CA . CYS A 1 65 ? 115.138 18.502 24.319 1.00 41.30 ? 65 CYS A CA 1 ATOM 489 C C . CYS A 1 65 ? 113.712 18.572 24.897 1.00 41.17 ? 65 CYS A C 1 ATOM 490 O O . CYS A 1 65 ? 113.460 19.264 25.894 1.00 38.52 ? 65 CYS A O 1 ATOM 491 C CB . CYS A 1 65 ? 115.848 17.260 24.891 1.00 41.80 ? 65 CYS A CB 1 ATOM 492 S SG . CYS A 1 65 ? 117.565 17.182 24.358 1.00 46.22 ? 65 CYS A SG 1 HETATM 493 N N . CSS A 1 66 ? 112.803 17.811 24.272 1.00 41.93 ? 66 CSS A N 1 HETATM 494 C CA . CSS A 1 66 ? 111.403 17.816 24.669 1.00 43.73 ? 66 CSS A CA 1 HETATM 495 C CB . CSS A 1 66 ? 110.608 16.816 23.811 1.00 44.50 ? 66 CSS A CB 1 HETATM 496 S SG . CSS A 1 66 ? 110.743 17.140 22.046 1.00 51.55 ? 66 CSS A SG 1 HETATM 497 S SD . CSS A 1 66 ? 109.404 18.738 22.099 1.00 66.41 ? 66 CSS A SD 1 HETATM 498 C C . CSS A 1 66 ? 111.314 17.419 26.124 1.00 43.36 ? 66 CSS A C 1 HETATM 499 O O . CSS A 1 66 ? 112.009 16.501 26.577 1.00 43.49 ? 66 CSS A O 1 ATOM 500 N N . GLN A 1 67 ? 110.441 18.083 26.857 1.00 42.75 ? 67 GLN A N 1 ATOM 501 C CA . GLN A 1 67 ? 110.318 17.818 28.280 1.00 42.39 ? 67 GLN A CA 1 ATOM 502 C C . GLN A 1 67 ? 109.080 18.538 28.838 1.00 42.02 ? 67 GLN A C 1 ATOM 503 O O . GLN A 1 67 ? 108.742 19.604 28.391 1.00 41.28 ? 67 GLN A O 1 ATOM 504 C CB . GLN A 1 67 ? 111.581 18.308 29.040 1.00 41.74 ? 67 GLN A CB 1 ATOM 505 C CG . GLN A 1 67 ? 111.903 19.826 28.833 1.00 39.77 ? 67 GLN A CG 1 ATOM 506 C CD . GLN A 1 67 ? 113.248 20.219 29.448 1.00 39.76 ? 67 GLN A CD 1 ATOM 507 O OE1 . GLN A 1 67 ? 113.320 20.549 30.619 1.00 37.11 ? 67 GLN A OE1 1 ATOM 508 N NE2 . GLN A 1 67 ? 114.294 20.210 28.649 1.00 40.35 ? 67 GLN A NE2 1 ATOM 509 N N . ASN A 1 68 ? 108.469 17.954 29.853 1.00 42.10 ? 68 ASN A N 1 ATOM 510 C CA . ASN A 1 68 ? 107.469 18.636 30.634 1.00 43.54 ? 68 ASN A CA 1 ATOM 511 C C . ASN A 1 68 ? 108.080 19.786 31.399 1.00 43.51 ? 68 ASN A C 1 ATOM 512 O O . ASN A 1 68 ? 109.253 19.738 31.771 1.00 43.51 ? 68 ASN A O 1 ATOM 513 C CB . ASN A 1 68 ? 106.714 17.635 31.519 1.00 42.70 ? 68 ASN A CB 1 ATOM 514 C CG . ASN A 1 68 ? 105.893 16.646 30.666 1.00 46.36 ? 68 ASN A CG 1 ATOM 515 O OD1 . ASN A 1 68 ? 104.941 17.042 29.990 1.00 47.82 ? 68 ASN A OD1 1 ATOM 516 N ND2 . ASN A 1 68 ? 106.294 15.384 30.649 1.00 43.10 ? 68 ASN A ND2 1 ATOM 517 N N . ILE A 1 69 ? 107.295 20.837 31.595 1.00 44.35 ? 69 ILE A N 1 ATOM 518 C CA . ILE A 1 69 ? 107.752 22.061 32.275 1.00 45.25 ? 69 ILE A CA 1 ATOM 519 C C . ILE A 1 69 ? 107.154 22.121 33.681 1.00 45.60 ? 69 ILE A C 1 ATOM 520 O O . ILE A 1 69 ? 106.051 21.634 33.893 1.00 45.14 ? 69 ILE A O 1 ATOM 521 C CB . ILE A 1 69 ? 107.382 23.308 31.383 1.00 46.03 ? 69 ILE A CB 1 ATOM 522 C CG1 . ILE A 1 69 ? 108.545 23.660 30.448 1.00 45.84 ? 69 ILE A CG1 1 ATOM 523 C CG2 . ILE A 1 69 ? 107.106 24.568 32.174 1.00 46.78 ? 69 ILE A CG2 1 ATOM 524 C CD1 . ILE A 1 69 ? 108.737 22.701 29.307 1.00 46.34 ? 69 ILE A CD1 1 ATOM 525 N N . ASP A 1 70 ? 107.894 22.691 34.641 1.00 45.58 ? 70 ASP A N 1 ATOM 526 C CA . ASP A 1 70 ? 107.346 23.037 35.978 1.00 45.98 ? 70 ASP A CA 1 ATOM 527 C C . ASP A 1 70 ? 106.364 24.275 35.889 1.00 46.23 ? 70 ASP A C 1 ATOM 528 O O . ASP A 1 70 ? 106.811 25.429 35.783 1.00 45.31 ? 70 ASP A O 1 ATOM 529 C CB . ASP A 1 70 ? 108.510 23.296 36.981 1.00 45.06 ? 70 ASP A CB 1 ATOM 530 C CG . ASP A 1 70 ? 108.039 23.685 38.393 1.00 45.17 ? 70 ASP A CG 1 ATOM 531 O OD1 . ASP A 1 70 ? 108.883 24.153 39.201 1.00 44.73 ? 70 ASP A OD1 1 ATOM 532 O OD2 . ASP A 1 70 ? 106.866 23.542 38.824 1.00 48.28 ? 70 ASP A OD2 1 ATOM 533 N N . GLN A 1 71 ? 105.055 23.996 35.931 1.00 46.83 ? 71 GLN A N 1 ATOM 534 C CA . GLN A 1 71 ? 103.979 25.024 35.902 1.00 48.18 ? 71 GLN A CA 1 ATOM 535 C C . GLN A 1 71 ? 103.341 25.266 37.287 1.00 47.84 ? 71 GLN A C 1 ATOM 536 O O . GLN A 1 71 ? 102.260 25.896 37.390 1.00 47.45 ? 71 GLN A O 1 ATOM 537 C CB . GLN A 1 71 ? 102.866 24.604 34.953 1.00 48.42 ? 71 GLN A CB 1 ATOM 538 C CG . GLN A 1 71 ? 103.305 24.211 33.549 1.00 53.80 ? 71 GLN A CG 1 ATOM 539 C CD . GLN A 1 71 ? 102.299 23.278 32.851 1.00 60.82 ? 71 GLN A CD 1 ATOM 540 O OE1 . GLN A 1 71 ? 102.640 22.620 31.866 1.00 64.41 ? 71 GLN A OE1 1 ATOM 541 N NE2 . GLN A 1 71 ? 101.066 23.222 33.363 1.00 62.78 ? 71 GLN A NE2 1 ATOM 542 N N . SER A 1 72 ? 104.012 24.791 38.343 1.00 46.69 ? 72 SER A N 1 ATOM 543 C CA . SER A 1 72 ? 103.489 24.914 39.722 1.00 46.08 ? 72 SER A CA 1 ATOM 544 C C . SER A 1 72 ? 103.432 26.341 40.242 1.00 45.91 ? 72 SER A C 1 ATOM 545 O O . SER A 1 72 ? 102.557 26.669 41.044 1.00 46.03 ? 72 SER A O 1 ATOM 546 C CB . SER A 1 72 ? 104.285 24.043 40.713 1.00 45.31 ? 72 SER A CB 1 ATOM 547 O OG . SER A 1 72 ? 104.083 22.676 40.425 1.00 44.79 ? 72 SER A OG 1 ATOM 548 N N . PHE A 1 73 ? 104.381 27.179 39.827 1.00 45.22 ? 73 PHE A N 1 ATOM 549 C CA . PHE A 1 73 ? 104.366 28.569 40.268 1.00 45.87 ? 73 PHE A CA 1 ATOM 550 C C . PHE A 1 73 ? 104.560 29.551 39.095 1.00 45.37 ? 73 PHE A C 1 ATOM 551 O O . PHE A 1 73 ? 105.619 30.194 39.004 1.00 46.01 ? 73 PHE A O 1 ATOM 552 C CB . PHE A 1 73 ? 105.410 28.814 41.391 1.00 46.30 ? 73 PHE A CB 1 ATOM 553 C CG . PHE A 1 73 ? 105.387 27.773 42.505 1.00 47.70 ? 73 PHE A CG 1 ATOM 554 C CD1 . PHE A 1 73 ? 104.398 27.812 43.504 1.00 47.54 ? 73 PHE A CD1 1 ATOM 555 C CD2 . PHE A 1 73 ? 106.330 26.731 42.535 1.00 45.89 ? 73 PHE A CD2 1 ATOM 556 C CE1 . PHE A 1 73 ? 104.365 26.849 44.511 1.00 47.20 ? 73 PHE A CE1 1 ATOM 557 C CE2 . PHE A 1 73 ? 106.294 25.764 43.542 1.00 44.68 ? 73 PHE A CE2 1 ATOM 558 C CZ . PHE A 1 73 ? 105.323 25.816 44.534 1.00 44.49 ? 73 PHE A CZ 1 ATOM 559 N N . PRO A 1 74 ? 103.565 29.700 38.203 1.00 44.77 ? 74 PRO A N 1 ATOM 560 C CA . PRO A 1 74 ? 103.730 30.630 37.066 1.00 44.42 ? 74 PRO A CA 1 ATOM 561 C C . PRO A 1 74 ? 104.126 32.029 37.556 1.00 42.94 ? 74 PRO A C 1 ATOM 562 O O . PRO A 1 74 ? 103.633 32.494 38.572 1.00 43.17 ? 74 PRO A O 1 ATOM 563 C CB . PRO A 1 74 ? 102.351 30.647 36.428 1.00 43.80 ? 74 PRO A CB 1 ATOM 564 C CG . PRO A 1 74 ? 101.786 29.358 36.774 1.00 43.85 ? 74 PRO A CG 1 ATOM 565 C CD . PRO A 1 74 ? 102.234 29.072 38.172 1.00 44.16 ? 74 PRO A CD 1 ATOM 566 N N . GLY A 1 75 ? 105.046 32.642 36.843 1.00 42.04 ? 75 GLY A N 1 ATOM 567 C CA . GLY A 1 75 ? 105.502 33.979 37.157 1.00 41.91 ? 75 GLY A CA 1 ATOM 568 C C . GLY A 1 75 ? 106.518 34.059 38.259 1.00 40.24 ? 75 GLY A C 1 ATOM 569 O O . GLY A 1 75 ? 107.002 35.128 38.564 1.00 39.67 ? 75 GLY A O 1 ATOM 570 N N . PHE A 1 76 ? 106.834 32.916 38.861 1.00 40.53 ? 76 PHE A N 1 ATOM 571 C CA . PHE A 1 76 ? 107.807 32.856 39.967 1.00 39.34 ? 76 PHE A CA 1 ATOM 572 C C . PHE A 1 76 ? 109.222 32.477 39.501 1.00 39.56 ? 76 PHE A C 1 ATOM 573 O O . PHE A 1 76 ? 109.446 31.429 38.922 1.00 37.95 ? 76 PHE A O 1 ATOM 574 C CB . PHE A 1 76 ? 107.315 31.873 41.023 1.00 40.04 ? 76 PHE A CB 1 ATOM 575 C CG . PHE A 1 76 ? 108.169 31.838 42.259 1.00 37.92 ? 76 PHE A CG 1 ATOM 576 C CD1 . PHE A 1 76 ? 108.554 33.020 42.898 1.00 37.56 ? 76 PHE A CD1 1 ATOM 577 C CD2 . PHE A 1 76 ? 108.623 30.625 42.762 1.00 38.36 ? 76 PHE A CD2 1 ATOM 578 C CE1 . PHE A 1 76 ? 109.382 32.961 44.043 1.00 40.08 ? 76 PHE A CE1 1 ATOM 579 C CE2 . PHE A 1 76 ? 109.419 30.568 43.916 1.00 35.12 ? 76 PHE A CE2 1 ATOM 580 C CZ . PHE A 1 76 ? 109.793 31.706 44.540 1.00 36.31 ? 76 PHE A CZ 1 ATOM 581 N N . HIS A 1 77 ? 110.179 33.351 39.775 1.00 40.51 ? 77 HIS A N 1 ATOM 582 C CA . HIS A 1 77 ? 111.552 33.118 39.404 1.00 41.71 ? 77 HIS A CA 1 ATOM 583 C C . HIS A 1 77 ? 112.211 31.879 40.058 1.00 41.65 ? 77 HIS A C 1 ATOM 584 O O . HIS A 1 77 ? 113.070 31.231 39.443 1.00 42.37 ? 77 HIS A O 1 ATOM 585 C CB . HIS A 1 77 ? 112.386 34.379 39.674 1.00 42.16 ? 77 HIS A CB 1 ATOM 586 C CG . HIS A 1 77 ? 113.775 34.289 39.128 1.00 45.48 ? 77 HIS A CG 1 ATOM 587 N ND1 . HIS A 1 77 ? 114.029 34.114 37.781 1.00 46.22 ? 77 HIS A ND1 1 ATOM 588 C CD2 . HIS A 1 77 ? 114.982 34.331 39.742 1.00 46.09 ? 77 HIS A CD2 1 ATOM 589 C CE1 . HIS A 1 77 ? 115.334 34.023 37.595 1.00 47.31 ? 77 HIS A CE1 1 ATOM 590 N NE2 . HIS A 1 77 ? 115.933 34.151 38.768 1.00 47.07 ? 77 HIS A NE2 1 ATOM 591 N N . GLY A 1 78 ? 111.838 31.567 41.295 1.00 41.76 ? 78 GLY A N 1 ATOM 592 C CA . GLY A 1 78 ? 112.430 30.436 42.030 1.00 40.79 ? 78 GLY A CA 1 ATOM 593 C C . GLY A 1 78 ? 112.234 29.130 41.292 1.00 41.24 ? 78 GLY A C 1 ATOM 594 O O . GLY A 1 78 ? 113.098 28.265 41.291 1.00 40.53 ? 78 GLY A O 1 ATOM 595 N N . SER A 1 79 ? 111.089 28.975 40.643 1.00 40.47 ? 79 SER A N 1 ATOM 596 C CA . SER A 1 79 ? 110.861 27.785 39.891 1.00 40.39 ? 79 SER A CA 1 ATOM 597 C C . SER A 1 79 ? 111.129 27.937 38.388 1.00 40.67 ? 79 SER A C 1 ATOM 598 O O . SER A 1 79 ? 111.636 27.016 37.726 1.00 40.21 ? 79 SER A O 1 ATOM 599 C CB . SER A 1 79 ? 109.451 27.266 40.157 1.00 40.48 ? 79 SER A CB 1 ATOM 600 O OG . SER A 1 79 ? 108.437 28.131 39.671 1.00 45.47 ? 79 SER A OG 1 ATOM 601 N N . GLU A 1 80 ? 110.751 29.088 37.848 1.00 39.75 ? 80 GLU A N 1 ATOM 602 C CA . GLU A 1 80 ? 110.910 29.333 36.422 1.00 40.29 ? 80 GLU A CA 1 ATOM 603 C C . GLU A 1 80 ? 112.356 29.432 35.965 1.00 38.63 ? 80 GLU A C 1 ATOM 604 O O . GLU A 1 80 ? 112.633 29.120 34.828 1.00 39.69 ? 80 GLU A O 1 ATOM 605 C CB . GLU A 1 80 ? 110.109 30.575 35.950 1.00 40.01 ? 80 GLU A CB 1 ATOM 606 C CG . GLU A 1 80 ? 108.598 30.353 35.955 1.00 41.81 ? 80 GLU A CG 1 ATOM 607 C CD . GLU A 1 80 ? 107.820 31.547 35.377 1.00 47.43 ? 80 GLU A CD 1 ATOM 608 O OE1 . GLU A 1 80 ? 106.614 31.380 35.094 1.00 46.99 ? 80 GLU A OE1 1 ATOM 609 O OE2 . GLU A 1 80 ? 108.420 32.653 35.206 1.00 48.67 ? 80 GLU A OE2 1 ATOM 610 N N . MET A 1 81 ? 113.266 29.878 36.819 1.00 37.44 ? 81 MET A N 1 ATOM 611 C CA . MET A 1 81 ? 114.705 29.855 36.472 1.00 36.99 ? 81 MET A CA 1 ATOM 612 C C . MET A 1 81 ? 115.243 28.494 36.064 1.00 37.10 ? 81 MET A C 1 ATOM 613 O O . MET A 1 81 ? 116.310 28.435 35.480 1.00 37.86 ? 81 MET A O 1 ATOM 614 C CB . MET A 1 81 ? 115.555 30.336 37.650 1.00 36.98 ? 81 MET A CB 1 ATOM 615 C CG . MET A 1 81 ? 115.520 29.420 38.838 1.00 36.85 ? 81 MET A CG 1 ATOM 616 S SD . MET A 1 81 ? 116.563 30.119 40.120 1.00 42.25 ? 81 MET A SD 1 ATOM 617 C CE . MET A 1 81 ? 118.193 29.698 39.506 1.00 34.56 ? 81 MET A CE 1 ATOM 618 N N . TRP A 1 82 ? 114.527 27.413 36.403 1.00 37.36 ? 82 TRP A N 1 ATOM 619 C CA . TRP A 1 82 ? 114.896 26.009 36.028 1.00 37.43 ? 82 TRP A CA 1 ATOM 620 C C . TRP A 1 82 ? 114.278 25.485 34.728 1.00 37.78 ? 82 TRP A C 1 ATOM 621 O O . TRP A 1 82 ? 114.743 24.475 34.132 1.00 37.99 ? 82 TRP A O 1 ATOM 622 C CB . TRP A 1 82 ? 114.526 25.070 37.206 1.00 37.24 ? 82 TRP A CB 1 ATOM 623 C CG . TRP A 1 82 ? 115.231 25.486 38.470 1.00 35.44 ? 82 TRP A CG 1 ATOM 624 C CD1 . TRP A 1 82 ? 114.665 25.991 39.596 1.00 35.88 ? 82 TRP A CD1 1 ATOM 625 C CD2 . TRP A 1 82 ? 116.639 25.498 38.680 1.00 34.55 ? 82 TRP A CD2 1 ATOM 626 N NE1 . TRP A 1 82 ? 115.639 26.285 40.526 1.00 38.87 ? 82 TRP A NE1 1 ATOM 627 C CE2 . TRP A 1 82 ? 116.868 25.987 39.983 1.00 38.34 ? 82 TRP A CE2 1 ATOM 628 C CE3 . TRP A 1 82 ? 117.744 25.067 37.924 1.00 37.67 ? 82 TRP A CE3 1 ATOM 629 C CZ2 . TRP A 1 82 ? 118.172 26.076 40.550 1.00 38.06 ? 82 TRP A CZ2 1 ATOM 630 C CZ3 . TRP A 1 82 ? 119.054 25.165 38.486 1.00 37.86 ? 82 TRP A CZ3 1 ATOM 631 C CH2 . TRP A 1 82 ? 119.242 25.662 39.788 1.00 36.34 ? 82 TRP A CH2 1 ATOM 632 N N . ASN A 1 83 ? 113.214 26.154 34.292 1.00 38.09 ? 83 ASN A N 1 ATOM 633 C CA . ASN A 1 83 ? 112.531 25.824 33.035 1.00 39.18 ? 83 ASN A CA 1 ATOM 634 C C . ASN A 1 83 ? 113.379 26.160 31.781 1.00 37.69 ? 83 ASN A C 1 ATOM 635 O O . ASN A 1 83 ? 114.181 27.069 31.811 1.00 37.62 ? 83 ASN A O 1 ATOM 636 C CB . ASN A 1 83 ? 111.157 26.560 32.994 1.00 39.99 ? 83 ASN A CB 1 ATOM 637 C CG . ASN A 1 83 ? 110.168 25.998 34.035 1.00 43.08 ? 83 ASN A CG 1 ATOM 638 O OD1 . ASN A 1 83 ? 110.344 24.866 34.514 1.00 45.98 ? 83 ASN A OD1 1 ATOM 639 N ND2 . ASN A 1 83 ? 109.143 26.780 34.396 1.00 41.96 ? 83 ASN A ND2 1 ATOM 640 N N . PRO A 1 84 ? 113.202 25.430 30.682 1.00 37.91 ? 84 PRO A N 1 ATOM 641 C CA . PRO A 1 84 ? 113.962 25.680 29.435 1.00 37.41 ? 84 PRO A CA 1 ATOM 642 C C . PRO A 1 84 ? 113.818 27.093 28.906 1.00 38.34 ? 84 PRO A C 1 ATOM 643 O O . PRO A 1 84 ? 112.741 27.665 28.987 1.00 37.55 ? 84 PRO A O 1 ATOM 644 C CB . PRO A 1 84 ? 113.316 24.727 28.457 1.00 37.63 ? 84 PRO A CB 1 ATOM 645 C CG . PRO A 1 84 ? 112.971 23.611 29.351 1.00 39.19 ? 84 PRO A CG 1 ATOM 646 C CD . PRO A 1 84 ? 112.293 24.274 30.548 1.00 37.51 ? 84 PRO A CD 1 ATOM 647 N N . ASN A 1 85 ? 114.899 27.646 28.367 1.00 38.96 ? 85 ASN A N 1 ATOM 648 C CA . ASN A 1 85 ? 114.914 29.020 27.864 1.00 40.12 ? 85 ASN A CA 1 ATOM 649 C C . ASN A 1 85 ? 115.214 29.060 26.361 1.00 40.69 ? 85 ASN A C 1 ATOM 650 O O . ASN A 1 85 ? 115.690 30.042 25.819 1.00 41.85 ? 85 ASN A O 1 ATOM 651 C CB . ASN A 1 85 ? 115.920 29.869 28.672 1.00 39.88 ? 85 ASN A CB 1 ATOM 652 C CG . ASN A 1 85 ? 117.335 29.304 28.614 1.00 41.06 ? 85 ASN A CG 1 ATOM 653 O OD1 . ASN A 1 85 ? 117.539 28.122 28.285 1.00 46.82 ? 85 ASN A OD1 1 ATOM 654 N ND2 . ASN A 1 85 ? 118.315 30.136 28.923 1.00 41.03 ? 85 ASN A ND2 1 ATOM 655 N N . THR A 1 86 ? 114.917 27.963 25.707 1.00 41.72 ? 86 THR A N 1 ATOM 656 C CA . THR A 1 86 ? 115.211 27.742 24.326 1.00 42.84 ? 86 THR A CA 1 ATOM 657 C C . THR A 1 86 ? 114.056 26.845 23.855 1.00 43.15 ? 86 THR A C 1 ATOM 658 O O . THR A 1 86 ? 113.563 26.048 24.659 1.00 44.59 ? 86 THR A O 1 ATOM 659 C CB . THR A 1 86 ? 116.592 27.084 24.328 1.00 43.57 ? 86 THR A CB 1 ATOM 660 O OG1 . THR A 1 86 ? 117.552 28.047 23.825 1.00 47.10 ? 86 THR A OG1 1 ATOM 661 C CG2 . THR A 1 86 ? 116.700 25.938 23.440 1.00 40.83 ? 86 THR A CG2 1 ATOM 662 N N A ASP A 1 87 ? 113.637 26.974 22.592 0.50 42.78 ? 87 ASP A N 1 ATOM 663 N N B ASP A 1 87 ? 113.577 27.004 22.624 0.50 42.86 ? 87 ASP A N 1 ATOM 664 C CA A ASP A 1 87 ? 112.614 26.094 21.997 0.50 42.84 ? 87 ASP A CA 1 ATOM 665 C CA B ASP A 1 87 ? 112.492 26.145 22.136 0.50 43.12 ? 87 ASP A CA 1 ATOM 666 C C A ASP A 1 87 ? 112.880 24.652 22.337 0.50 42.62 ? 87 ASP A C 1 ATOM 667 C C B ASP A 1 87 ? 112.839 24.687 22.297 0.50 42.71 ? 87 ASP A C 1 ATOM 668 O O A ASP A 1 87 ? 114.029 24.224 22.313 0.50 42.47 ? 87 ASP A O 1 ATOM 669 O O B ASP A 1 87 ? 113.993 24.300 22.141 0.50 42.44 ? 87 ASP A O 1 ATOM 670 C CB A ASP A 1 87 ? 112.598 26.152 20.460 0.50 42.73 ? 87 ASP A CB 1 ATOM 671 C CB B ASP A 1 87 ? 112.133 26.407 20.668 0.50 42.92 ? 87 ASP A CB 1 ATOM 672 C CG A ASP A 1 87 ? 112.304 27.518 19.911 0.50 42.00 ? 87 ASP A CG 1 ATOM 673 C CG B ASP A 1 87 ? 110.858 27.207 20.508 0.50 43.65 ? 87 ASP A CG 1 ATOM 674 O OD1 A ASP A 1 87 ? 111.304 27.656 19.203 0.50 42.21 ? 87 ASP A OD1 1 ATOM 675 O OD1 B ASP A 1 87 ? 109.711 26.684 20.738 0.50 42.52 ? 87 ASP A OD1 1 ATOM 676 O OD2 A ASP A 1 87 ? 113.034 28.498 20.067 0.50 44.44 ? 87 ASP A OD2 1 ATOM 677 O OD2 B ASP A 1 87 ? 110.925 28.378 20.098 0.50 44.82 ? 87 ASP A OD2 1 ATOM 678 N N . LEU A 1 88 ? 111.818 23.895 22.606 1.00 42.58 ? 88 LEU A N 1 ATOM 679 C CA . LEU A 1 88 ? 111.958 22.484 22.787 1.00 43.00 ? 88 LEU A CA 1 ATOM 680 C C . LEU A 1 88 ? 111.893 21.831 21.404 1.00 43.78 ? 88 LEU A C 1 ATOM 681 O O . LEU A 1 88 ? 111.175 22.283 20.511 1.00 43.86 ? 88 LEU A O 1 ATOM 682 C CB . LEU A 1 88 ? 110.865 21.915 23.707 1.00 42.67 ? 88 LEU A CB 1 ATOM 683 C CG . LEU A 1 88 ? 110.678 22.583 25.079 1.00 41.48 ? 88 LEU A CG 1 ATOM 684 C CD1 . LEU A 1 88 ? 109.710 21.775 25.932 1.00 40.78 ? 88 LEU A CD1 1 ATOM 685 C CD2 . LEU A 1 88 ? 111.981 22.692 25.779 1.00 41.96 ? 88 LEU A CD2 1 ATOM 686 N N . SER A 1 89 ? 112.622 20.747 21.233 1.00 43.24 ? 89 SER A N 1 ATOM 687 C CA . SER A 1 89 ? 112.620 20.086 19.964 1.00 43.78 ? 89 SER A CA 1 ATOM 688 C C . SER A 1 89 ? 113.270 18.742 20.167 1.00 44.16 ? 89 SER A C 1 ATOM 689 O O . SER A 1 89 ? 114.134 18.584 21.024 1.00 43.88 ? 89 SER A O 1 ATOM 690 C CB . SER A 1 89 ? 113.394 20.919 18.935 1.00 42.74 ? 89 SER A CB 1 ATOM 691 O OG . SER A 1 89 ? 113.599 20.149 17.752 1.00 44.80 ? 89 SER A OG 1 ATOM 692 N N . GLU A 1 90 ? 112.843 17.761 19.404 1.00 45.28 ? 90 GLU A N 1 ATOM 693 C CA . GLU A 1 90 ? 113.557 16.492 19.414 1.00 45.99 ? 90 GLU A CA 1 ATOM 694 C C . GLU A 1 90 ? 114.941 16.654 18.832 1.00 45.59 ? 90 GLU A C 1 ATOM 695 O O . GLU A 1 90 ? 115.820 15.813 19.056 1.00 45.73 ? 90 GLU A O 1 ATOM 696 C CB . GLU A 1 90 ? 112.811 15.458 18.645 1.00 46.36 ? 90 GLU A CB 1 ATOM 697 C CG . GLU A 1 90 ? 111.617 14.913 19.383 1.00 47.23 ? 90 GLU A CG 1 ATOM 698 C CD . GLU A 1 90 ? 111.133 13.696 18.659 1.00 50.24 ? 90 GLU A CD 1 ATOM 699 O OE1 . GLU A 1 90 ? 110.205 13.806 17.810 1.00 54.61 ? 90 GLU A OE1 1 ATOM 700 O OE2 . GLU A 1 90 ? 111.727 12.643 18.897 1.00 51.35 ? 90 GLU A OE2 1 ATOM 701 N N . ASP A 1 91 ? 115.127 17.772 18.129 1.00 44.54 ? 91 ASP A N 1 ATOM 702 C CA . ASP A 1 91 ? 116.375 18.101 17.484 1.00 44.12 ? 91 ASP A CA 1 ATOM 703 C C . ASP A 1 91 ? 117.083 18.993 18.493 1.00 42.90 ? 91 ASP A C 1 ATOM 704 O O . ASP A 1 91 ? 116.896 20.220 18.568 1.00 42.07 ? 91 ASP A O 1 ATOM 705 C CB . ASP A 1 91 ? 116.112 18.724 16.099 1.00 44.10 ? 91 ASP A CB 1 ATOM 706 C CG . ASP A 1 91 ? 117.352 19.254 15.435 1.00 47.61 ? 91 ASP A CG 1 ATOM 707 O OD1 . ASP A 1 91 ? 118.504 18.936 15.822 1.00 49.95 ? 91 ASP A OD1 1 ATOM 708 O OD2 . ASP A 1 91 ? 117.262 20.027 14.471 1.00 52.27 ? 91 ASP A OD2 1 ATOM 709 N N . CYS A 1 92 ? 117.845 18.326 19.356 1.00 42.01 ? 92 CYS A N 1 ATOM 710 C CA . CYS A 1 92 ? 118.349 18.980 20.549 1.00 40.65 ? 92 CYS A CA 1 ATOM 711 C C . CYS A 1 92 ? 119.779 18.498 20.940 1.00 40.28 ? 92 CYS A C 1 ATOM 712 O O . CYS A 1 92 ? 120.330 18.929 21.959 1.00 38.96 ? 92 CYS A O 1 ATOM 713 C CB . CYS A 1 92 ? 117.357 18.718 21.655 1.00 40.19 ? 92 CYS A CB 1 ATOM 714 S SG . CYS A 1 92 ? 117.370 17.016 22.311 1.00 43.94 ? 92 CYS A SG 1 ATOM 715 N N . LEU A 1 93 ? 120.380 17.646 20.106 1.00 39.05 ? 93 LEU A N 1 ATOM 716 C CA . LEU A 1 93 ? 121.747 17.144 20.380 1.00 39.67 ? 93 LEU A CA 1 ATOM 717 C C . LEU A 1 93 ? 122.866 18.123 20.004 1.00 38.95 ? 93 LEU A C 1 ATOM 718 O O . LEU A 1 93 ? 123.552 17.986 18.997 1.00 39.49 ? 93 LEU A O 1 ATOM 719 C CB . LEU A 1 93 ? 121.948 15.729 19.800 1.00 39.20 ? 93 LEU A CB 1 ATOM 720 C CG . LEU A 1 93 ? 120.993 14.683 20.347 1.00 40.47 ? 93 LEU A CG 1 ATOM 721 C CD1 . LEU A 1 93 ? 121.346 13.279 19.834 1.00 42.93 ? 93 LEU A CD1 1 ATOM 722 C CD2 . LEU A 1 93 ? 120.919 14.711 21.890 1.00 40.67 ? 93 LEU A CD2 1 ATOM 723 N N . TYR A 1 94 ? 123.030 19.116 20.858 1.00 39.35 ? 94 TYR A N 1 ATOM 724 C CA . TYR A 1 94 ? 123.981 20.222 20.690 1.00 39.80 ? 94 TYR A CA 1 ATOM 725 C C . TYR A 1 94 ? 124.762 20.402 21.991 1.00 39.86 ? 94 TYR A C 1 ATOM 726 O O . TYR A 1 94 ? 124.352 19.924 23.067 1.00 38.54 ? 94 TYR A O 1 ATOM 727 C CB . TYR A 1 94 ? 123.261 21.562 20.287 1.00 39.68 ? 94 TYR A CB 1 ATOM 728 C CG . TYR A 1 94 ? 122.458 21.372 18.993 1.00 40.16 ? 94 TYR A CG 1 ATOM 729 C CD1 . TYR A 1 94 ? 121.126 20.910 19.034 1.00 39.33 ? 94 TYR A CD1 1 ATOM 730 C CD2 . TYR A 1 94 ? 123.037 21.593 17.754 1.00 37.36 ? 94 TYR A CD2 1 ATOM 731 C CE1 . TYR A 1 94 ? 120.400 20.681 17.882 1.00 42.22 ? 94 TYR A CE1 1 ATOM 732 C CE2 . TYR A 1 94 ? 122.316 21.342 16.561 1.00 41.06 ? 94 TYR A CE2 1 ATOM 733 C CZ . TYR A 1 94 ? 121.006 20.883 16.635 1.00 43.58 ? 94 TYR A CZ 1 ATOM 734 O OH . TYR A 1 94 ? 120.284 20.614 15.486 1.00 45.99 ? 94 TYR A OH 1 ATOM 735 N N . LEU A 1 95 ? 125.882 21.110 21.856 1.00 40.12 ? 95 LEU A N 1 ATOM 736 C CA . LEU A 1 95 ? 126.781 21.397 22.935 1.00 40.32 ? 95 LEU A CA 1 ATOM 737 C C . LEU A 1 95 ? 127.356 22.808 22.774 1.00 40.54 ? 95 LEU A C 1 ATOM 738 O O . LEU A 1 95 ? 127.330 23.381 21.667 1.00 40.20 ? 95 LEU A O 1 ATOM 739 C CB . LEU A 1 95 ? 127.892 20.338 23.004 1.00 40.20 ? 95 LEU A CB 1 ATOM 740 C CG . LEU A 1 95 ? 128.942 20.116 21.908 1.00 41.82 ? 95 LEU A CG 1 ATOM 741 C CD1 . LEU A 1 95 ? 130.061 21.222 21.820 1.00 38.82 ? 95 LEU A CD1 1 ATOM 742 C CD2 . LEU A 1 95 ? 129.544 18.704 22.158 1.00 41.35 ? 95 LEU A CD2 1 ATOM 743 N N . ASN A 1 96 ? 127.830 23.356 23.891 1.00 39.83 ? 96 ASN A N 1 ATOM 744 C CA . ASN A 1 96 ? 128.460 24.655 23.946 1.00 40.58 ? 96 ASN A CA 1 ATOM 745 C C . ASN A 1 96 ? 129.899 24.569 24.472 1.00 40.63 ? 96 ASN A C 1 ATOM 746 O O . ASN A 1 96 ? 130.256 23.673 25.290 1.00 39.75 ? 96 ASN A O 1 ATOM 747 C CB . ASN A 1 96 ? 127.659 25.588 24.833 1.00 40.28 ? 96 ASN A CB 1 ATOM 748 C CG . ASN A 1 96 ? 126.169 25.441 24.639 1.00 42.00 ? 96 ASN A CG 1 ATOM 749 O OD1 . ASN A 1 96 ? 125.618 25.777 23.568 1.00 44.15 ? 96 ASN A OD1 1 ATOM 750 N ND2 . ASN A 1 96 ? 125.492 24.931 25.671 1.00 34.74 ? 96 ASN A ND2 1 ATOM 751 N N . VAL A 1 97 ? 130.721 25.499 23.999 1.00 41.09 ? 97 VAL A N 1 ATOM 752 C CA . VAL A 1 97 ? 132.143 25.574 24.374 1.00 40.98 ? 97 VAL A CA 1 ATOM 753 C C . VAL A 1 97 ? 132.473 27.035 24.647 1.00 42.07 ? 97 VAL A C 1 ATOM 754 O O . VAL A 1 97 ? 132.205 27.902 23.798 1.00 41.64 ? 97 VAL A O 1 ATOM 755 C CB . VAL A 1 97 ? 133.105 25.028 23.252 1.00 41.51 ? 97 VAL A CB 1 ATOM 756 C CG1 . VAL A 1 97 ? 134.577 25.090 23.712 1.00 41.09 ? 97 VAL A CG1 1 ATOM 757 C CG2 . VAL A 1 97 ? 132.792 23.593 22.847 1.00 40.78 ? 97 VAL A CG2 1 ATOM 758 N N . TRP A 1 98 ? 133.001 27.330 25.846 1.00 42.45 ? 98 TRP A N 1 ATOM 759 C CA . TRP A 1 98 ? 133.526 28.647 26.136 1.00 43.07 ? 98 TRP A CA 1 ATOM 760 C C . TRP A 1 98 ? 135.008 28.465 26.298 1.00 43.98 ? 98 TRP A C 1 ATOM 761 O O . TRP A 1 98 ? 135.461 27.584 27.054 1.00 43.99 ? 98 TRP A O 1 ATOM 762 C CB . TRP A 1 98 ? 132.975 29.245 27.430 1.00 42.41 ? 98 TRP A CB 1 ATOM 763 C CG . TRP A 1 98 ? 131.530 29.629 27.371 1.00 43.86 ? 98 TRP A CG 1 ATOM 764 C CD1 . TRP A 1 98 ? 131.007 30.902 27.124 1.00 43.12 ? 98 TRP A CD1 1 ATOM 765 C CD2 . TRP A 1 98 ? 130.398 28.769 27.606 1.00 42.53 ? 98 TRP A CD2 1 ATOM 766 N NE1 . TRP A 1 98 ? 129.632 30.852 27.188 1.00 43.06 ? 98 TRP A NE1 1 ATOM 767 C CE2 . TRP A 1 98 ? 129.228 29.566 27.485 1.00 43.07 ? 98 TRP A CE2 1 ATOM 768 C CE3 . TRP A 1 98 ? 130.249 27.402 27.931 1.00 41.70 ? 98 TRP A CE3 1 ATOM 769 C CZ2 . TRP A 1 98 ? 127.922 29.025 27.662 1.00 40.74 ? 98 TRP A CZ2 1 ATOM 770 C CZ3 . TRP A 1 98 ? 128.960 26.864 28.084 1.00 40.47 ? 98 TRP A CZ3 1 ATOM 771 C CH2 . TRP A 1 98 ? 127.822 27.672 27.960 1.00 39.63 ? 98 TRP A CH2 1 ATOM 772 N N . ILE A 1 99 ? 135.761 29.295 25.581 1.00 44.38 ? 99 ILE A N 1 ATOM 773 C CA . ILE A 1 99 ? 137.185 29.227 25.610 1.00 45.35 ? 99 ILE A CA 1 ATOM 774 C C . ILE A 1 99 ? 137.739 30.590 26.049 1.00 45.97 ? 99 ILE A C 1 ATOM 775 O O . ILE A 1 99 ? 137.155 31.631 25.761 1.00 47.09 ? 99 ILE A O 1 ATOM 776 C CB . ILE A 1 99 ? 137.775 28.687 24.251 1.00 45.87 ? 99 ILE A CB 1 ATOM 777 C CG1 . ILE A 1 99 ? 137.787 29.721 23.137 1.00 45.76 ? 99 ILE A CG1 1 ATOM 778 C CG2 . ILE A 1 99 ? 137.063 27.453 23.783 1.00 44.45 ? 99 ILE A CG2 1 ATOM 779 C CD1 . ILE A 1 99 ? 138.983 29.416 22.170 1.00 47.40 ? 99 ILE A CD1 1 ATOM 780 N N . PRO A 1 100 ? 138.830 30.591 26.806 1.00 46.38 ? 100 PRO A N 1 ATOM 781 C CA . PRO A 1 100 ? 139.468 31.857 27.221 1.00 46.91 ? 100 PRO A CA 1 ATOM 782 C C . PRO A 1 100 ? 139.973 32.599 25.973 1.00 47.72 ? 100 PRO A C 1 ATOM 783 O O . PRO A 1 100 ? 140.205 31.958 24.944 1.00 46.41 ? 100 PRO A O 1 ATOM 784 C CB . PRO A 1 100 ? 140.677 31.385 28.023 1.00 47.07 ? 100 PRO A CB 1 ATOM 785 C CG . PRO A 1 100 ? 140.314 29.952 28.409 1.00 46.15 ? 100 PRO A CG 1 ATOM 786 C CD . PRO A 1 100 ? 139.546 29.404 27.310 1.00 45.32 ? 100 PRO A CD 1 ATOM 787 N N . ALA A 1 101 ? 140.071 33.928 26.068 1.00 48.46 ? 101 ALA A N 1 ATOM 788 C CA . ALA A 1 101 ? 140.709 34.757 25.053 1.00 49.88 ? 101 ALA A CA 1 ATOM 789 C C . ALA A 1 101 ? 141.738 35.632 25.746 1.00 50.07 ? 101 ALA A C 1 ATOM 790 O O . ALA A 1 101 ? 141.396 36.324 26.686 1.00 50.22 ? 101 ALA A O 1 ATOM 791 C CB . ALA A 1 101 ? 139.673 35.633 24.337 1.00 49.43 ? 101 ALA A CB 1 ATOM 792 N N . PRO A 1 102 ? 142.992 35.642 25.297 1.00 51.38 ? 102 PRO A N 1 ATOM 793 C CA . PRO A 1 102 ? 143.470 34.827 24.184 1.00 51.52 ? 102 PRO A CA 1 ATOM 794 C C . PRO A 1 102 ? 143.389 33.345 24.359 1.00 51.40 ? 102 PRO A C 1 ATOM 795 O O . PRO A 1 102 ? 143.584 32.800 25.453 1.00 52.00 ? 102 PRO A O 1 ATOM 796 C CB . PRO A 1 102 ? 144.941 35.247 24.040 1.00 51.63 ? 102 PRO A CB 1 ATOM 797 C CG . PRO A 1 102 ? 145.281 35.936 25.329 1.00 52.09 ? 102 PRO A CG 1 ATOM 798 C CD . PRO A 1 102 ? 144.035 36.569 25.808 1.00 51.66 ? 102 PRO A CD 1 ATOM 799 N N . LYS A 1 103 ? 143.141 32.735 23.215 1.00 51.91 ? 103 LYS A N 1 ATOM 800 C CA . LYS A 1 103 ? 143.074 31.331 22.985 1.00 52.31 ? 103 LYS A CA 1 ATOM 801 C C . LYS A 1 103 ? 144.175 30.611 23.729 1.00 52.81 ? 103 LYS A C 1 ATOM 802 O O . LYS A 1 103 ? 145.319 31.001 23.642 1.00 52.94 ? 103 LYS A O 1 ATOM 803 C CB . LYS A 1 103 ? 143.210 31.092 21.502 1.00 52.34 ? 103 LYS A CB 1 ATOM 804 C CG . LYS A 1 103 ? 143.134 29.646 21.128 1.00 55.00 ? 103 LYS A CG 1 ATOM 805 C CD . LYS A 1 103 ? 142.917 29.503 19.639 1.00 59.16 ? 103 LYS A CD 1 ATOM 806 C CE . LYS A 1 103 ? 142.540 28.067 19.290 1.00 61.60 ? 103 LYS A CE 1 ATOM 807 N NZ . LYS A 1 103 ? 143.702 27.143 19.418 1.00 62.09 ? 103 LYS A NZ 1 ATOM 808 N N . PRO A 1 104 ? 143.806 29.587 24.496 1.00 52.94 ? 104 PRO A N 1 ATOM 809 C CA . PRO A 1 104 ? 144.743 28.871 25.319 1.00 52.62 ? 104 PRO A CA 1 ATOM 810 C C . PRO A 1 104 ? 145.559 27.881 24.502 1.00 52.70 ? 104 PRO A C 1 ATOM 811 O O . PRO A 1 104 ? 145.212 27.612 23.355 1.00 52.35 ? 104 PRO A O 1 ATOM 812 C CB . PRO A 1 104 ? 143.823 28.166 26.321 1.00 52.99 ? 104 PRO A CB 1 ATOM 813 C CG . PRO A 1 104 ? 142.614 27.865 25.538 1.00 53.39 ? 104 PRO A CG 1 ATOM 814 C CD . PRO A 1 104 ? 142.430 29.073 24.656 1.00 52.79 ? 104 PRO A CD 1 ATOM 815 N N . LYS A 1 105 ? 146.648 27.374 25.088 1.00 52.63 ? 105 LYS A N 1 ATOM 816 C CA . LYS A 1 105 ? 147.509 26.382 24.444 1.00 53.28 ? 105 LYS A CA 1 ATOM 817 C C . LYS A 1 105 ? 147.128 24.932 24.762 1.00 53.07 ? 105 LYS A C 1 ATOM 818 O O . LYS A 1 105 ? 147.111 24.082 23.862 1.00 53.79 ? 105 LYS A O 1 ATOM 819 C CB . LYS A 1 105 ? 148.985 26.579 24.830 1.00 54.20 ? 105 LYS A CB 1 ATOM 820 C CG . LYS A 1 105 ? 149.616 27.911 24.458 1.00 56.00 ? 105 LYS A CG 1 ATOM 821 C CD . LYS A 1 105 ? 149.997 27.985 22.975 1.00 56.73 ? 105 LYS A CD 1 ATOM 822 C CE . LYS A 1 105 ? 150.773 29.285 22.695 1.00 55.49 ? 105 LYS A CE 1 ATOM 823 N NZ . LYS A 1 105 ? 150.055 30.455 23.312 1.00 55.76 ? 105 LYS A NZ 1 ATOM 824 N N . ASN A 1 106 ? 146.842 24.641 26.033 1.00 51.56 ? 106 ASN A N 1 ATOM 825 C CA . ASN A 1 106 ? 146.494 23.285 26.436 1.00 50.29 ? 106 ASN A CA 1 ATOM 826 C C . ASN A 1 106 ? 145.646 23.394 27.711 1.00 48.53 ? 106 ASN A C 1 ATOM 827 O O . ASN A 1 106 ? 146.015 22.883 28.764 1.00 47.89 ? 106 ASN A O 1 ATOM 828 C CB . ASN A 1 106 ? 147.800 22.568 26.729 1.00 50.60 ? 106 ASN A CB 1 ATOM 829 C CG . ASN A 1 106 ? 147.781 21.115 26.399 1.00 54.85 ? 106 ASN A CG 1 ATOM 830 O OD1 . ASN A 1 106 ? 146.941 20.609 25.630 1.00 57.42 ? 106 ASN A OD1 1 ATOM 831 N ND2 . ASN A 1 106 ? 148.765 20.404 26.991 1.00 62.35 ? 106 ASN A ND2 1 ATOM 832 N N . ALA A 1 107 ? 144.535 24.115 27.624 1.00 46.62 ? 107 ALA A N 1 ATOM 833 C CA . ALA A 1 107 ? 143.655 24.339 28.787 1.00 45.55 ? 107 ALA A CA 1 ATOM 834 C C . ALA A 1 107 ? 142.996 23.071 29.347 1.00 43.84 ? 107 ALA A C 1 ATOM 835 O O . ALA A 1 107 ? 142.618 22.173 28.620 1.00 44.52 ? 107 ALA A O 1 ATOM 836 C CB . ALA A 1 107 ? 142.597 25.395 28.457 1.00 45.17 ? 107 ALA A CB 1 ATOM 837 N N . THR A 1 108 ? 142.893 22.990 30.655 1.00 44.07 ? 108 THR A N 1 ATOM 838 C CA . THR A 1 108 ? 142.038 21.985 31.303 1.00 43.71 ? 108 THR A CA 1 ATOM 839 C C . THR A 1 108 ? 140.564 22.204 30.870 1.00 42.82 ? 108 THR A C 1 ATOM 840 O O . THR A 1 108 ? 140.076 23.367 30.798 1.00 43.50 ? 108 THR A O 1 ATOM 841 C CB . THR A 1 108 ? 142.215 22.085 32.855 1.00 44.52 ? 108 THR A CB 1 ATOM 842 O OG1 . THR A 1 108 ? 143.391 21.364 33.245 1.00 46.35 ? 108 THR A OG1 1 ATOM 843 C CG2 . THR A 1 108 ? 141.095 21.342 33.636 1.00 44.63 ? 108 THR A CG2 1 ATOM 844 N N . VAL A 1 109 ? 139.858 21.101 30.604 1.00 41.81 ? 109 VAL A N 1 ATOM 845 C CA . VAL A 1 109 ? 138.461 21.158 30.199 1.00 40.55 ? 109 VAL A CA 1 ATOM 846 C C . VAL A 1 109 ? 137.486 20.752 31.311 1.00 40.42 ? 109 VAL A C 1 ATOM 847 O O . VAL A 1 109 ? 137.629 19.705 31.926 1.00 39.85 ? 109 VAL A O 1 ATOM 848 C CB . VAL A 1 109 ? 138.205 20.330 28.945 1.00 40.22 ? 109 VAL A CB 1 ATOM 849 C CG1 . VAL A 1 109 ? 136.726 20.475 28.534 1.00 38.77 ? 109 VAL A CG1 1 ATOM 850 C CG2 . VAL A 1 109 ? 139.176 20.791 27.761 1.00 38.90 ? 109 VAL A CG2 1 ATOM 851 N N . LEU A 1 110 ? 136.490 21.601 31.539 1.00 40.11 ? 110 LEU A N 1 ATOM 852 C CA . LEU A 1 110 ? 135.402 21.343 32.494 1.00 40.08 ? 110 LEU A CA 1 ATOM 853 C C . LEU A 1 110 ? 134.099 21.023 31.765 1.00 39.47 ? 110 LEU A C 1 ATOM 854 O O . LEU A 1 110 ? 133.577 21.891 31.089 1.00 39.54 ? 110 LEU A O 1 ATOM 855 C CB . LEU A 1 110 ? 135.206 22.580 33.398 1.00 39.86 ? 110 LEU A CB 1 ATOM 856 C CG . LEU A 1 110 ? 135.907 22.475 34.732 1.00 42.63 ? 110 LEU A CG 1 ATOM 857 C CD1 . LEU A 1 110 ? 137.355 22.126 34.567 1.00 41.77 ? 110 LEU A CD1 1 ATOM 858 C CD2 . LEU A 1 110 ? 135.797 23.756 35.508 1.00 46.55 ? 110 LEU A CD2 1 ATOM 859 N N . ILE A 1 111 ? 133.572 19.793 31.892 1.00 38.84 ? 111 ILE A N 1 ATOM 860 C CA . ILE A 1 111 ? 132.349 19.416 31.158 1.00 37.25 ? 111 ILE A CA 1 ATOM 861 C C . ILE A 1 111 ? 131.151 19.298 32.056 1.00 36.78 ? 111 ILE A C 1 ATOM 862 O O . ILE A 1 111 ? 131.136 18.411 32.922 1.00 37.17 ? 111 ILE A O 1 ATOM 863 C CB . ILE A 1 111 ? 132.512 18.116 30.355 1.00 37.84 ? 111 ILE A CB 1 ATOM 864 C CG1 . ILE A 1 111 ? 133.737 18.202 29.414 1.00 38.13 ? 111 ILE A CG1 1 ATOM 865 C CG2 . ILE A 1 111 ? 131.195 17.813 29.641 1.00 34.33 ? 111 ILE A CG2 1 ATOM 866 C CD1 . ILE A 1 111 ? 133.909 17.013 28.476 1.00 39.27 ? 111 ILE A CD1 1 ATOM 867 N N . TRP A 1 112 ? 130.174 20.212 31.879 1.00 34.44 ? 112 TRP A N 1 ATOM 868 C CA . TRP A 1 112 ? 128.980 20.246 32.723 1.00 33.49 ? 112 TRP A CA 1 ATOM 869 C C . TRP A 1 112 ? 127.829 19.350 32.259 1.00 33.77 ? 112 TRP A C 1 ATOM 870 O O . TRP A 1 112 ? 127.450 19.357 31.068 1.00 33.64 ? 112 TRP A O 1 ATOM 871 C CB . TRP A 1 112 ? 128.462 21.671 32.871 1.00 33.44 ? 112 TRP A CB 1 ATOM 872 C CG . TRP A 1 112 ? 127.178 21.828 33.685 1.00 32.04 ? 112 TRP A CG 1 ATOM 873 C CD1 . TRP A 1 112 ? 125.895 22.088 33.203 1.00 31.19 ? 112 TRP A CD1 1 ATOM 874 C CD2 . TRP A 1 112 ? 127.060 21.777 35.112 1.00 32.46 ? 112 TRP A CD2 1 ATOM 875 N NE1 . TRP A 1 112 ? 125.012 22.163 34.253 1.00 31.38 ? 112 TRP A NE1 1 ATOM 876 C CE2 . TRP A 1 112 ? 125.692 22.002 35.433 1.00 32.89 ? 112 TRP A CE2 1 ATOM 877 C CE3 . TRP A 1 112 ? 127.978 21.549 36.168 1.00 33.40 ? 112 TRP A CE3 1 ATOM 878 C CZ2 . TRP A 1 112 ? 125.222 22.027 36.760 1.00 33.44 ? 112 TRP A CZ2 1 ATOM 879 C CZ3 . TRP A 1 112 ? 127.510 21.587 37.490 1.00 29.23 ? 112 TRP A CZ3 1 ATOM 880 C CH2 . TRP A 1 112 ? 126.146 21.808 37.766 1.00 30.95 ? 112 TRP A CH2 1 ATOM 881 N N . ILE A 1 113 ? 127.259 18.614 33.211 1.00 33.18 ? 113 ILE A N 1 ATOM 882 C CA . ILE A 1 113 ? 126.070 17.806 32.947 1.00 33.60 ? 113 ILE A CA 1 ATOM 883 C C . ILE A 1 113 ? 124.963 18.245 33.864 1.00 34.54 ? 113 ILE A C 1 ATOM 884 O O . ILE A 1 113 ? 125.028 18.015 35.088 1.00 35.41 ? 113 ILE A O 1 ATOM 885 C CB . ILE A 1 113 ? 126.372 16.258 33.114 1.00 34.53 ? 113 ILE A CB 1 ATOM 886 C CG1 . ILE A 1 113 ? 127.559 15.795 32.198 1.00 32.86 ? 113 ILE A CG1 1 ATOM 887 C CG2 . ILE A 1 113 ? 125.067 15.431 32.872 1.00 31.23 ? 113 ILE A CG2 1 ATOM 888 C CD1 . ILE A 1 113 ? 127.966 14.274 32.358 1.00 33.54 ? 113 ILE A CD1 1 ATOM 889 N N . TYR A 1 114 ? 123.909 18.842 33.294 1.00 34.67 ? 114 TYR A N 1 ATOM 890 C CA . TYR A 1 114 ? 122.796 19.352 34.103 1.00 32.49 ? 114 TYR A CA 1 ATOM 891 C C . TYR A 1 114 ? 121.932 18.265 34.766 1.00 32.74 ? 114 TYR A C 1 ATOM 892 O O . TYR A 1 114 ? 121.808 17.108 34.291 1.00 33.67 ? 114 TYR A O 1 ATOM 893 C CB . TYR A 1 114 ? 121.943 20.349 33.296 1.00 32.57 ? 114 TYR A CB 1 ATOM 894 C CG . TYR A 1 114 ? 121.288 19.746 32.056 1.00 29.30 ? 114 TYR A CG 1 ATOM 895 C CD1 . TYR A 1 114 ? 120.242 18.829 32.157 1.00 27.19 ? 114 TYR A CD1 1 ATOM 896 C CD2 . TYR A 1 114 ? 121.750 20.071 30.787 1.00 29.63 ? 114 TYR A CD2 1 ATOM 897 C CE1 . TYR A 1 114 ? 119.689 18.239 31.024 1.00 29.98 ? 114 TYR A CE1 1 ATOM 898 C CE2 . TYR A 1 114 ? 121.218 19.467 29.652 1.00 28.30 ? 114 TYR A CE2 1 ATOM 899 C CZ . TYR A 1 114 ? 120.180 18.588 29.760 1.00 29.95 ? 114 TYR A CZ 1 ATOM 900 O OH . TYR A 1 114 ? 119.629 18.029 28.619 1.00 32.37 ? 114 TYR A OH 1 ATOM 901 N N . GLY A 1 115 ? 121.315 18.646 35.871 1.00 32.78 ? 115 GLY A N 1 ATOM 902 C CA . GLY A 1 115 ? 120.281 17.838 36.459 1.00 32.67 ? 115 GLY A CA 1 ATOM 903 C C . GLY A 1 115 ? 118.876 18.260 35.978 1.00 33.40 ? 115 GLY A C 1 ATOM 904 O O . GLY A 1 115 ? 118.710 19.018 34.992 1.00 32.12 ? 115 GLY A O 1 ATOM 905 N N . GLY A 1 116 ? 117.886 17.699 36.653 1.00 32.84 ? 116 GLY A N 1 ATOM 906 C CA . GLY A 1 116 ? 116.520 17.750 36.225 1.00 35.12 ? 116 GLY A CA 1 ATOM 907 C C . GLY A 1 116 ? 115.810 16.419 36.387 1.00 35.84 ? 116 GLY A C 1 ATOM 908 O O . GLY A 1 116 ? 114.761 16.163 35.763 1.00 35.87 ? 116 GLY A O 1 ATOM 909 N N . GLY A 1 117 ? 116.363 15.539 37.222 1.00 36.12 ? 117 GLY A N 1 ATOM 910 C CA . GLY A 1 117 ? 115.659 14.272 37.487 1.00 35.07 ? 117 GLY A CA 1 ATOM 911 C C . GLY A 1 117 ? 115.733 13.320 36.336 1.00 34.22 ? 117 GLY A C 1 ATOM 912 O O . GLY A 1 117 ? 115.019 12.362 36.316 1.00 35.98 ? 117 GLY A O 1 ATOM 913 N N . PHE A 1 118 ? 116.600 13.569 35.367 1.00 34.58 ? 118 PHE A N 1 ATOM 914 C CA . PHE A 1 118 ? 116.580 12.796 34.138 1.00 35.67 ? 118 PHE A CA 1 ATOM 915 C C . PHE A 1 118 ? 115.293 13.053 33.343 1.00 36.52 ? 118 PHE A C 1 ATOM 916 O O . PHE A 1 118 ? 115.090 12.451 32.273 1.00 36.89 ? 118 PHE A O 1 ATOM 917 C CB . PHE A 1 118 ? 116.773 11.258 34.398 1.00 36.30 ? 118 PHE A CB 1 ATOM 918 C CG . PHE A 1 118 ? 118.114 10.884 35.045 1.00 34.04 ? 118 PHE A CG 1 ATOM 919 C CD1 . PHE A 1 118 ? 119.297 10.941 34.317 1.00 32.86 ? 118 PHE A CD1 1 ATOM 920 C CD2 . PHE A 1 118 ? 118.155 10.455 36.377 1.00 33.86 ? 118 PHE A CD2 1 ATOM 921 C CE1 . PHE A 1 118 ? 120.530 10.586 34.919 1.00 33.78 ? 118 PHE A CE1 1 ATOM 922 C CE2 . PHE A 1 118 ? 119.342 10.080 36.997 1.00 30.24 ? 118 PHE A CE2 1 ATOM 923 C CZ . PHE A 1 118 ? 120.541 10.162 36.267 1.00 33.53 ? 118 PHE A CZ 1 ATOM 924 N N . GLN A 1 119 ? 114.437 13.962 33.827 1.00 36.79 ? 119 GLN A N 1 ATOM 925 C CA . GLN A 1 119 ? 113.158 14.232 33.126 1.00 37.79 ? 119 GLN A CA 1 ATOM 926 C C . GLN A 1 119 ? 113.173 15.596 32.469 1.00 37.49 ? 119 GLN A C 1 ATOM 927 O O . GLN A 1 119 ? 112.478 15.789 31.477 1.00 38.61 ? 119 GLN A O 1 ATOM 928 C CB . GLN A 1 119 ? 111.922 14.142 34.048 1.00 37.29 ? 119 GLN A CB 1 ATOM 929 C CG . GLN A 1 119 ? 111.791 12.834 34.882 1.00 37.68 ? 119 GLN A CG 1 ATOM 930 C CD . GLN A 1 119 ? 112.105 11.592 34.085 1.00 39.34 ? 119 GLN A CD 1 ATOM 931 O OE1 . GLN A 1 119 ? 113.163 10.964 34.279 1.00 45.35 ? 119 GLN A OE1 1 ATOM 932 N NE2 . GLN A 1 119 ? 111.216 11.219 33.208 1.00 34.86 ? 119 GLN A NE2 1 ATOM 933 N N . THR A 1 120 ? 113.932 16.525 33.045 1.00 36.27 ? 120 THR A N 1 ATOM 934 C CA . THR A 1 120 ? 114.018 17.890 32.579 1.00 36.03 ? 120 THR A CA 1 ATOM 935 C C . THR A 1 120 ? 115.473 18.388 32.485 1.00 36.08 ? 120 THR A C 1 ATOM 936 O O . THR A 1 120 ? 116.418 17.684 32.867 1.00 36.80 ? 120 THR A O 1 ATOM 937 C CB . THR A 1 120 ? 113.237 18.870 33.521 1.00 37.94 ? 120 THR A CB 1 ATOM 938 O OG1 . THR A 1 120 ? 113.850 18.868 34.833 1.00 37.14 ? 120 THR A OG1 1 ATOM 939 C CG2 . THR A 1 120 ? 111.682 18.445 33.730 1.00 34.02 ? 120 THR A CG2 1 ATOM 940 N N . GLY A 1 121 ? 115.628 19.621 32.025 1.00 33.57 ? 121 GLY A N 1 ATOM 941 C CA . GLY A 1 121 ? 116.897 20.265 32.021 1.00 34.39 ? 121 GLY A CA 1 ATOM 942 C C . GLY A 1 121 ? 117.361 20.776 30.674 1.00 33.88 ? 121 GLY A C 1 ATOM 943 O O . GLY A 1 121 ? 116.943 20.293 29.617 1.00 33.64 ? 121 GLY A O 1 ATOM 944 N N . THR A 1 122 ? 118.235 21.759 30.723 1.00 33.70 ? 122 THR A N 1 ATOM 945 C CA . THR A 1 122 ? 118.911 22.173 29.517 1.00 35.18 ? 122 THR A CA 1 ATOM 946 C C . THR A 1 122 ? 120.245 22.857 29.891 1.00 35.81 ? 122 THR A C 1 ATOM 947 O O . THR A 1 122 ? 120.395 23.383 31.009 1.00 34.28 ? 122 THR A O 1 ATOM 948 C CB . THR A 1 122 ? 117.955 23.082 28.636 1.00 35.96 ? 122 THR A CB 1 ATOM 949 O OG1 . THR A 1 122 ? 118.640 23.549 27.470 1.00 38.30 ? 122 THR A OG1 1 ATOM 950 C CG2 . THR A 1 122 ? 117.571 24.396 29.393 1.00 32.11 ? 122 THR A CG2 1 ATOM 951 N N . SER A 1 123 ? 121.220 22.824 28.973 1.00 36.34 ? 123 SER A N 1 ATOM 952 C CA . SER A 1 123 ? 122.508 23.429 29.254 1.00 38.01 ? 123 SER A CA 1 ATOM 953 C C . SER A 1 123 ? 122.499 24.946 29.075 1.00 40.08 ? 123 SER A C 1 ATOM 954 O O . SER A 1 123 ? 123.507 25.610 29.352 1.00 42.20 ? 123 SER A O 1 ATOM 955 C CB . SER A 1 123 ? 123.589 22.818 28.366 1.00 38.33 ? 123 SER A CB 1 ATOM 956 O OG . SER A 1 123 ? 123.273 22.983 26.999 1.00 39.70 ? 123 SER A OG 1 ATOM 957 N N . SER A 1 124 ? 121.380 25.507 28.605 1.00 39.70 ? 124 SER A N 1 ATOM 958 C CA . SER A 1 124 ? 121.339 26.915 28.237 1.00 39.28 ? 124 SER A CA 1 ATOM 959 C C . SER A 1 124 ? 120.831 27.801 29.367 1.00 38.55 ? 124 SER A C 1 ATOM 960 O O . SER A 1 124 ? 120.717 28.996 29.205 1.00 37.88 ? 124 SER A O 1 ATOM 961 C CB . SER A 1 124 ? 120.535 27.137 26.928 1.00 40.36 ? 124 SER A CB 1 ATOM 962 O OG . SER A 1 124 ? 119.209 26.608 26.954 1.00 41.27 ? 124 SER A OG 1 ATOM 963 N N . LEU A 1 125 ? 120.569 27.237 30.533 1.00 37.72 ? 125 LEU A N 1 ATOM 964 C CA . LEU A 1 125 ? 120.217 28.070 31.667 1.00 36.90 ? 125 LEU A CA 1 ATOM 965 C C . LEU A 1 125 ? 121.307 29.065 32.060 1.00 38.03 ? 125 LEU A C 1 ATOM 966 O O . LEU A 1 125 ? 122.509 28.833 31.883 1.00 37.55 ? 125 LEU A O 1 ATOM 967 C CB . LEU A 1 125 ? 119.818 27.226 32.876 1.00 38.41 ? 125 LEU A CB 1 ATOM 968 C CG . LEU A 1 125 ? 118.744 26.136 32.712 1.00 36.02 ? 125 LEU A CG 1 ATOM 969 C CD1 . LEU A 1 125 ? 118.420 25.519 34.117 1.00 31.94 ? 125 LEU A CD1 1 ATOM 970 C CD2 . LEU A 1 125 ? 117.502 26.746 32.001 1.00 36.57 ? 125 LEU A CD2 1 ATOM 971 N N . HIS A 1 126 ? 120.851 30.201 32.586 1.00 38.71 ? 126 HIS A N 1 ATOM 972 C CA . HIS A 1 126 ? 121.657 31.319 33.006 1.00 39.19 ? 126 HIS A CA 1 ATOM 973 C C . HIS A 1 126 ? 122.659 30.873 34.085 1.00 39.28 ? 126 HIS A C 1 ATOM 974 O O . HIS A 1 126 ? 123.799 31.351 34.129 1.00 38.54 ? 126 HIS A O 1 ATOM 975 C CB . HIS A 1 126 ? 120.673 32.410 33.526 1.00 40.22 ? 126 HIS A CB 1 ATOM 976 C CG . HIS A 1 126 ? 121.333 33.624 34.095 1.00 44.94 ? 126 HIS A CG 1 ATOM 977 N ND1 . HIS A 1 126 ? 122.246 34.383 33.387 1.00 51.79 ? 126 HIS A ND1 1 ATOM 978 C CD2 . HIS A 1 126 ? 121.213 34.218 35.308 1.00 50.41 ? 126 HIS A CD2 1 ATOM 979 C CE1 . HIS A 1 126 ? 122.666 35.385 34.142 1.00 53.14 ? 126 HIS A CE1 1 ATOM 980 N NE2 . HIS A 1 126 ? 122.046 35.317 35.309 1.00 53.66 ? 126 HIS A NE2 1 ATOM 981 N N . VAL A 1 127 ? 122.221 29.949 34.947 1.00 38.79 ? 127 VAL A N 1 ATOM 982 C CA . VAL A 1 127 ? 123.029 29.492 36.065 1.00 39.41 ? 127 VAL A CA 1 ATOM 983 C C . VAL A 1 127 ? 124.104 28.508 35.622 1.00 39.33 ? 127 VAL A C 1 ATOM 984 O O . VAL A 1 127 ? 125.013 28.213 36.391 1.00 39.81 ? 127 VAL A O 1 ATOM 985 C CB . VAL A 1 127 ? 122.175 28.920 37.228 1.00 39.78 ? 127 VAL A CB 1 ATOM 986 C CG1 . VAL A 1 127 ? 121.435 30.082 37.928 1.00 40.44 ? 127 VAL A CG1 1 ATOM 987 C CG2 . VAL A 1 127 ? 121.225 27.780 36.721 1.00 36.68 ? 127 VAL A CG2 1 ATOM 988 N N . TYR A 1 128 ? 124.026 28.055 34.369 1.00 38.46 ? 128 TYR A N 1 ATOM 989 C CA . TYR A 1 128 ? 125.065 27.193 33.763 1.00 37.54 ? 128 TYR A CA 1 ATOM 990 C C . TYR A 1 128 ? 125.985 27.891 32.746 1.00 37.13 ? 128 TYR A C 1 ATOM 991 O O . TYR A 1 128 ? 126.667 27.239 31.965 1.00 36.77 ? 128 TYR A O 1 ATOM 992 C CB . TYR A 1 128 ? 124.466 25.939 33.090 1.00 35.44 ? 128 TYR A CB 1 ATOM 993 C CG . TYR A 1 128 ? 123.442 25.158 33.910 1.00 34.62 ? 128 TYR A CG 1 ATOM 994 C CD1 . TYR A 1 128 ? 123.544 25.046 35.307 1.00 34.46 ? 128 TYR A CD1 1 ATOM 995 C CD2 . TYR A 1 128 ? 122.382 24.491 33.271 1.00 34.87 ? 128 TYR A CD2 1 ATOM 996 C CE1 . TYR A 1 128 ? 122.577 24.337 36.052 1.00 32.53 ? 128 TYR A CE1 1 ATOM 997 C CE2 . TYR A 1 128 ? 121.437 23.766 33.992 1.00 30.08 ? 128 TYR A CE2 1 ATOM 998 C CZ . TYR A 1 128 ? 121.542 23.698 35.379 1.00 33.11 ? 128 TYR A CZ 1 ATOM 999 O OH . TYR A 1 128 ? 120.602 22.997 36.089 1.00 32.23 ? 128 TYR A OH 1 ATOM 1000 N N . ASP A 1 129 ? 126.008 29.199 32.745 1.00 38.56 ? 129 ASP A N 1 ATOM 1001 C CA . ASP A 1 129 ? 126.758 29.964 31.741 1.00 39.51 ? 129 ASP A CA 1 ATOM 1002 C C . ASP A 1 129 ? 128.244 29.900 32.081 1.00 40.34 ? 129 ASP A C 1 ATOM 1003 O O . ASP A 1 129 ? 128.637 30.382 33.126 1.00 39.88 ? 129 ASP A O 1 ATOM 1004 C CB . ASP A 1 129 ? 126.338 31.413 31.883 1.00 41.10 ? 129 ASP A CB 1 ATOM 1005 C CG . ASP A 1 129 ? 126.840 32.305 30.744 1.00 43.12 ? 129 ASP A CG 1 ATOM 1006 O OD1 . ASP A 1 129 ? 127.899 32.009 30.150 1.00 43.34 ? 129 ASP A OD1 1 ATOM 1007 O OD2 . ASP A 1 129 ? 126.220 33.338 30.420 1.00 47.64 ? 129 ASP A OD2 1 ATOM 1008 N N . GLY A 1 130 ? 129.047 29.266 31.214 1.00 40.15 ? 130 GLY A N 1 ATOM 1009 C CA . GLY A 1 130 ? 130.438 29.005 31.484 1.00 39.71 ? 130 GLY A CA 1 ATOM 1010 C C . GLY A 1 130 ? 131.480 30.112 31.238 1.00 40.56 ? 130 GLY A C 1 ATOM 1011 O O . GLY A 1 130 ? 132.675 29.840 31.314 1.00 38.96 ? 130 GLY A O 1 ATOM 1012 N N . LYS A 1 131 ? 131.042 31.351 30.996 1.00 40.40 ? 131 LYS A N 1 ATOM 1013 C CA . LYS A 1 131 ? 131.955 32.421 30.586 1.00 40.30 ? 131 LYS A CA 1 ATOM 1014 C C . LYS A 1 131 ? 132.762 33.007 31.723 1.00 40.48 ? 131 LYS A C 1 ATOM 1015 O O . LYS A 1 131 ? 133.897 33.441 31.513 1.00 39.74 ? 131 LYS A O 1 ATOM 1016 C CB . LYS A 1 131 ? 131.195 33.538 29.816 1.00 40.38 ? 131 LYS A CB 1 ATOM 1017 C CG . LYS A 1 131 ? 130.233 34.309 30.625 1.00 41.18 ? 131 LYS A CG 1 ATOM 1018 C CD . LYS A 1 131 ? 129.441 35.262 29.782 1.00 44.96 ? 131 LYS A CD 1 ATOM 1019 C CE . LYS A 1 131 ? 128.603 36.199 30.651 1.00 46.20 ? 131 LYS A CE 1 ATOM 1020 N NZ . LYS A 1 131 ? 127.872 37.238 29.782 1.00 50.60 ? 131 LYS A NZ 1 ATOM 1021 N N . PHE A 1 132 ? 132.175 33.062 32.923 1.00 40.71 ? 132 PHE A N 1 ATOM 1022 C CA . PHE A 1 132 ? 132.910 33.508 34.080 1.00 41.52 ? 132 PHE A CA 1 ATOM 1023 C C . PHE A 1 132 ? 134.075 32.534 34.319 1.00 41.85 ? 132 PHE A C 1 ATOM 1024 O O . PHE A 1 132 ? 135.190 32.967 34.429 1.00 42.53 ? 132 PHE A O 1 ATOM 1025 C CB . PHE A 1 132 ? 131.980 33.673 35.299 1.00 42.66 ? 132 PHE A CB 1 ATOM 1026 C CG . PHE A 1 132 ? 130.759 34.497 35.003 1.00 44.89 ? 132 PHE A CG 1 ATOM 1027 C CD1 . PHE A 1 132 ? 130.863 35.881 34.859 1.00 46.14 ? 132 PHE A CD1 1 ATOM 1028 C CD2 . PHE A 1 132 ? 129.527 33.875 34.759 1.00 48.23 ? 132 PHE A CD2 1 ATOM 1029 C CE1 . PHE A 1 132 ? 129.744 36.672 34.513 1.00 46.61 ? 132 PHE A CE1 1 ATOM 1030 C CE2 . PHE A 1 132 ? 128.387 34.630 34.429 1.00 51.94 ? 132 PHE A CE2 1 ATOM 1031 C CZ . PHE A 1 132 ? 128.502 36.062 34.297 1.00 50.17 ? 132 PHE A CZ 1 ATOM 1032 N N . LEU A 1 133 ? 133.827 31.220 34.322 1.00 42.00 ? 133 LEU A N 1 ATOM 1033 C CA . LEU A 1 133 ? 134.887 30.227 34.559 1.00 42.27 ? 133 LEU A CA 1 ATOM 1034 C C . LEU A 1 133 ? 136.009 30.326 33.512 1.00 43.52 ? 133 LEU A C 1 ATOM 1035 O O . LEU A 1 133 ? 137.213 30.296 33.861 1.00 42.87 ? 133 LEU A O 1 ATOM 1036 C CB . LEU A 1 133 ? 134.324 28.796 34.583 1.00 41.75 ? 133 LEU A CB 1 ATOM 1037 C CG . LEU A 1 133 ? 133.502 28.426 35.822 1.00 41.35 ? 133 LEU A CG 1 ATOM 1038 C CD1 . LEU A 1 133 ? 132.569 27.228 35.598 1.00 39.54 ? 133 LEU A CD1 1 ATOM 1039 C CD2 . LEU A 1 133 ? 134.402 28.179 37.008 1.00 42.11 ? 133 LEU A CD2 1 ATOM 1040 N N . ALA A 1 134 ? 135.613 30.456 32.243 1.00 43.56 ? 134 ALA A N 1 ATOM 1041 C CA . ALA A 1 134 ? 136.571 30.553 31.151 1.00 44.97 ? 134 ALA A CA 1 ATOM 1042 C C . ALA A 1 134 ? 137.405 31.853 31.327 1.00 46.02 ? 134 ALA A C 1 ATOM 1043 O O . ALA A 1 134 ? 138.651 31.829 31.316 1.00 46.42 ? 134 ALA A O 1 ATOM 1044 C CB . ALA A 1 134 ? 135.827 30.523 29.814 1.00 44.51 ? 134 ALA A CB 1 ATOM 1045 N N . ARG A 1 135 ? 136.718 32.960 31.605 1.00 45.91 ? 135 ARG A N 1 ATOM 1046 C CA . ARG A 1 135 ? 137.384 34.226 31.903 1.00 46.89 ? 135 ARG A CA 1 ATOM 1047 C C . ARG A 1 135 ? 138.393 34.192 33.079 1.00 47.26 ? 135 ARG A C 1 ATOM 1048 O O . ARG A 1 135 ? 139.540 34.662 32.938 1.00 47.61 ? 135 ARG A O 1 ATOM 1049 C CB . ARG A 1 135 ? 136.322 35.296 32.178 1.00 46.66 ? 135 ARG A CB 1 ATOM 1050 C CG . ARG A 1 135 ? 136.824 36.623 32.659 1.00 48.75 ? 135 ARG A CG 1 ATOM 1051 C CD . ARG A 1 135 ? 137.604 37.384 31.604 1.00 55.53 ? 135 ARG A CD 1 ATOM 1052 N NE . ARG A 1 135 ? 138.035 38.661 32.147 1.00 58.16 ? 135 ARG A NE 1 ATOM 1053 C CZ . ARG A 1 135 ? 139.232 38.873 32.683 1.00 61.48 ? 135 ARG A CZ 1 ATOM 1054 N NH1 . ARG A 1 135 ? 140.143 37.891 32.725 1.00 60.21 ? 135 ARG A NH1 1 ATOM 1055 N NH2 . ARG A 1 135 ? 139.522 40.082 33.172 1.00 62.77 ? 135 ARG A NH2 1 ATOM 1056 N N . VAL A 1 136 ? 137.899 33.749 34.241 1.00 46.64 ? 136 VAL A N 1 ATOM 1057 C CA . VAL A 1 136 ? 138.554 33.896 35.544 1.00 45.26 ? 136 VAL A CA 1 ATOM 1058 C C . VAL A 1 136 ? 139.622 32.820 35.788 1.00 45.21 ? 136 VAL A C 1 ATOM 1059 O O . VAL A 1 136 ? 140.699 33.122 36.279 1.00 45.35 ? 136 VAL A O 1 ATOM 1060 C CB . VAL A 1 136 ? 137.488 33.888 36.694 1.00 45.37 ? 136 VAL A CB 1 ATOM 1061 C CG1 . VAL A 1 136 ? 138.141 33.855 38.074 1.00 43.74 ? 136 VAL A CG1 1 ATOM 1062 C CG2 . VAL A 1 136 ? 136.640 35.111 36.619 1.00 44.79 ? 136 VAL A CG2 1 ATOM 1063 N N . GLU A 1 137 ? 139.330 31.571 35.412 1.00 44.61 ? 137 GLU A N 1 ATOM 1064 C CA . GLU A 1 137 ? 140.251 30.448 35.620 1.00 43.97 ? 137 GLU A CA 1 ATOM 1065 C C . GLU A 1 137 ? 141.020 29.951 34.405 1.00 42.88 ? 137 GLU A C 1 ATOM 1066 O O . GLU A 1 137 ? 141.903 29.087 34.527 1.00 42.66 ? 137 GLU A O 1 ATOM 1067 C CB . GLU A 1 137 ? 139.503 29.278 36.306 1.00 43.45 ? 137 GLU A CB 1 ATOM 1068 C CG . GLU A 1 137 ? 139.063 29.629 37.717 1.00 43.99 ? 137 GLU A CG 1 ATOM 1069 C CD . GLU A 1 137 ? 140.235 29.969 38.631 1.00 48.11 ? 137 GLU A CD 1 ATOM 1070 O OE1 . GLU A 1 137 ? 141.325 29.359 38.459 1.00 51.52 ? 137 GLU A OE1 1 ATOM 1071 O OE2 . GLU A 1 137 ? 140.090 30.853 39.519 1.00 48.08 ? 137 GLU A OE2 1 ATOM 1072 N N A ARG A 1 138 ? 140.680 30.483 33.237 0.50 42.66 ? 138 ARG A N 1 ATOM 1073 N N B ARG A 1 138 ? 140.657 30.469 33.233 0.50 42.91 ? 138 ARG A N 1 ATOM 1074 C CA A ARG A 1 138 ? 141.300 30.068 31.991 0.50 42.05 ? 138 ARG A CA 1 ATOM 1075 C CA B ARG A 1 138 ? 141.269 30.104 31.953 0.50 42.55 ? 138 ARG A CA 1 ATOM 1076 C C A ARG A 1 138 ? 141.205 28.542 31.884 0.50 41.93 ? 138 ARG A C 1 ATOM 1077 C C B ARG A 1 138 ? 141.062 28.629 31.600 0.50 42.30 ? 138 ARG A C 1 ATOM 1078 O O A ARG A 1 138 ? 142.181 27.840 31.625 0.50 42.20 ? 138 ARG A O 1 ATOM 1079 O O B ARG A 1 138 ? 141.834 28.034 30.839 0.50 42.53 ? 138 ARG A O 1 ATOM 1080 C CB A ARG A 1 138 ? 142.746 30.599 31.879 0.50 41.94 ? 138 ARG A CB 1 ATOM 1081 C CB B ARG A 1 138 ? 142.758 30.493 31.902 0.50 42.66 ? 138 ARG A CB 1 ATOM 1082 C CG A ARG A 1 138 ? 142.861 32.143 31.694 0.50 43.35 ? 138 ARG A CG 1 ATOM 1083 C CG B ARG A 1 138 ? 143.097 31.715 31.030 0.50 45.37 ? 138 ARG A CG 1 ATOM 1084 C CD A ARG A 1 138 ? 144.322 32.715 31.517 0.50 43.74 ? 138 ARG A CD 1 ATOM 1085 C CD B ARG A 1 138 ? 143.215 33.068 31.769 0.50 47.49 ? 138 ARG A CD 1 ATOM 1086 N NE A ARG A 1 138 ? 145.207 31.804 30.781 0.50 42.42 ? 138 ARG A NE 1 ATOM 1087 N NE B ARG A 1 138 ? 142.038 33.887 31.540 0.50 48.58 ? 138 ARG A NE 1 ATOM 1088 C CZ A ARG A 1 138 ? 145.263 31.716 29.454 0.50 43.97 ? 138 ARG A CZ 1 ATOM 1089 C CZ B ARG A 1 138 ? 141.851 34.662 30.472 0.50 49.56 ? 138 ARG A CZ 1 ATOM 1090 N NH1 A ARG A 1 138 ? 146.090 30.836 28.899 0.50 42.32 ? 138 ARG A NH1 1 ATOM 1091 N NH1 B ARG A 1 138 ? 142.794 34.742 29.520 0.50 47.90 ? 138 ARG A NH1 1 ATOM 1092 N NH2 A ARG A 1 138 ? 144.497 32.504 28.680 0.50 41.33 ? 138 ARG A NH2 1 ATOM 1093 N NH2 B ARG A 1 138 ? 140.712 35.351 30.359 0.50 45.18 ? 138 ARG A NH2 1 ATOM 1094 N N . VAL A 1 139 ? 140.006 28.035 32.139 1.00 41.86 ? 139 VAL A N 1 ATOM 1095 C CA . VAL A 1 139 ? 139.615 26.682 31.727 1.00 41.02 ? 139 VAL A CA 1 ATOM 1096 C C . VAL A 1 139 ? 138.714 26.823 30.499 1.00 41.33 ? 139 VAL A C 1 ATOM 1097 O O . VAL A 1 139 ? 138.168 27.910 30.255 1.00 41.60 ? 139 VAL A O 1 ATOM 1098 C CB . VAL A 1 139 ? 138.877 25.907 32.845 1.00 40.72 ? 139 VAL A CB 1 ATOM 1099 C CG1 . VAL A 1 139 ? 139.874 25.560 33.979 1.00 38.79 ? 139 VAL A CG1 1 ATOM 1100 C CG2 . VAL A 1 139 ? 137.692 26.684 33.344 1.00 38.34 ? 139 VAL A CG2 1 ATOM 1101 N N . ILE A 1 140 ? 138.573 25.735 29.740 1.00 41.01 ? 140 ILE A N 1 ATOM 1102 C CA . ILE A 1 140 ? 137.507 25.617 28.770 1.00 40.07 ? 140 ILE A CA 1 ATOM 1103 C C . ILE A 1 140 ? 136.301 24.938 29.445 1.00 40.20 ? 140 ILE A C 1 ATOM 1104 O O . ILE A 1 140 ? 136.460 23.905 30.083 1.00 40.32 ? 140 ILE A O 1 ATOM 1105 C CB . ILE A 1 140 ? 138.000 24.817 27.531 1.00 40.11 ? 140 ILE A CB 1 ATOM 1106 C CG1 . ILE A 1 140 ? 139.042 25.651 26.746 1.00 40.26 ? 140 ILE A CG1 1 ATOM 1107 C CG2 . ILE A 1 140 ? 136.828 24.391 26.638 1.00 38.44 ? 140 ILE A CG2 1 ATOM 1108 C CD1 . ILE A 1 140 ? 139.688 24.892 25.557 1.00 41.83 ? 140 ILE A CD1 1 ATOM 1109 N N . VAL A 1 141 ? 135.109 25.528 29.302 1.00 39.47 ? 141 VAL A N 1 ATOM 1110 C CA . VAL A 1 141 ? 133.904 24.927 29.803 1.00 38.71 ? 141 VAL A CA 1 ATOM 1111 C C . VAL A 1 141 ? 133.090 24.390 28.624 1.00 38.87 ? 141 VAL A C 1 ATOM 1112 O O . VAL A 1 141 ? 132.821 25.127 27.669 1.00 38.88 ? 141 VAL A O 1 ATOM 1113 C CB . VAL A 1 141 ? 133.077 25.944 30.564 1.00 39.09 ? 141 VAL A CB 1 ATOM 1114 C CG1 . VAL A 1 141 ? 131.769 25.287 31.161 1.00 38.81 ? 141 VAL A CG1 1 ATOM 1115 C CG2 . VAL A 1 141 ? 133.938 26.671 31.638 1.00 37.76 ? 141 VAL A CG2 1 ATOM 1116 N N . VAL A 1 142 ? 132.697 23.122 28.699 1.00 37.57 ? 142 VAL A N 1 ATOM 1117 C CA . VAL A 1 142 ? 131.814 22.490 27.719 1.00 38.16 ? 142 VAL A CA 1 ATOM 1118 C C . VAL A 1 142 ? 130.508 22.062 28.437 1.00 39.30 ? 142 VAL A C 1 ATOM 1119 O O . VAL A 1 142 ? 130.541 21.640 29.630 1.00 39.43 ? 142 VAL A O 1 ATOM 1120 C CB . VAL A 1 142 ? 132.483 21.234 27.052 1.00 38.14 ? 142 VAL A CB 1 ATOM 1121 C CG1 . VAL A 1 142 ? 131.570 20.542 26.037 1.00 39.08 ? 142 VAL A CG1 1 ATOM 1122 C CG2 . VAL A 1 142 ? 133.814 21.605 26.377 1.00 36.61 ? 142 VAL A CG2 1 ATOM 1123 N N . SER A 1 143 ? 129.373 22.222 27.737 1.00 39.10 ? 143 SER A N 1 ATOM 1124 C CA . SER A 1 143 ? 128.072 21.681 28.159 1.00 38.95 ? 143 SER A CA 1 ATOM 1125 C C . SER A 1 143 ? 127.275 21.078 27.002 1.00 38.94 ? 143 SER A C 1 ATOM 1126 O O . SER A 1 143 ? 127.442 21.471 25.862 1.00 39.04 ? 143 SER A O 1 ATOM 1127 C CB . SER A 1 143 ? 127.263 22.687 28.983 1.00 39.01 ? 143 SER A CB 1 ATOM 1128 O OG . SER A 1 143 ? 126.806 23.771 28.216 1.00 39.94 ? 143 SER A OG 1 ATOM 1129 N N . MET A 1 144 ? 126.444 20.076 27.291 1.00 37.98 ? 144 MET A N 1 ATOM 1130 C CA . MET A 1 144 ? 125.662 19.412 26.248 1.00 37.44 ? 144 MET A CA 1 ATOM 1131 C C . MET A 1 144 ? 124.183 19.264 26.646 1.00 37.60 ? 144 MET A C 1 ATOM 1132 O O . MET A 1 144 ? 123.838 19.165 27.846 1.00 36.49 ? 144 MET A O 1 ATOM 1133 C CB . MET A 1 144 ? 126.266 18.029 25.864 1.00 37.34 ? 144 MET A CB 1 ATOM 1134 C CG . MET A 1 144 ? 125.799 16.834 26.699 1.00 35.49 ? 144 MET A CG 1 ATOM 1135 S SD . MET A 1 144 ? 126.286 16.833 28.461 1.00 36.68 ? 144 MET A SD 1 ATOM 1136 C CE . MET A 1 144 ? 128.027 16.346 28.320 1.00 37.34 ? 144 MET A CE 1 ATOM 1137 N N . ASN A 1 145 ? 123.321 19.271 25.629 1.00 37.53 ? 145 ASN A N 1 ATOM 1138 C CA . ASN A 1 145 ? 121.974 18.784 25.798 1.00 38.45 ? 145 ASN A CA 1 ATOM 1139 C C . ASN A 1 145 ? 121.956 17.285 25.520 1.00 38.14 ? 145 ASN A C 1 ATOM 1140 O O . ASN A 1 145 ? 122.618 16.777 24.607 1.00 39.36 ? 145 ASN A O 1 ATOM 1141 C CB . ASN A 1 145 ? 120.979 19.522 24.896 1.00 38.11 ? 145 ASN A CB 1 ATOM 1142 C CG . ASN A 1 145 ? 120.797 20.984 25.281 1.00 39.55 ? 145 ASN A CG 1 ATOM 1143 O OD1 . ASN A 1 145 ? 121.232 21.425 26.344 1.00 38.19 ? 145 ASN A OD1 1 ATOM 1144 N ND2 . ASN A 1 145 ? 120.158 21.755 24.394 1.00 40.42 ? 145 ASN A ND2 1 ATOM 1145 N N . TYR A 1 146 ? 121.221 16.576 26.354 1.00 37.06 ? 146 TYR A N 1 ATOM 1146 C CA . TYR A 1 146 ? 121.060 15.172 26.190 1.00 35.67 ? 146 TYR A CA 1 ATOM 1147 C C . TYR A 1 146 ? 119.548 14.879 26.418 1.00 36.09 ? 146 TYR A C 1 ATOM 1148 O O . TYR A 1 146 ? 118.895 15.574 27.160 1.00 35.54 ? 146 TYR A O 1 ATOM 1149 C CB . TYR A 1 146 ? 121.974 14.459 27.203 1.00 35.38 ? 146 TYR A CB 1 ATOM 1150 C CG . TYR A 1 146 ? 121.618 14.696 28.666 1.00 30.38 ? 146 TYR A CG 1 ATOM 1151 C CD1 . TYR A 1 146 ? 120.714 13.895 29.310 1.00 26.38 ? 146 TYR A CD1 1 ATOM 1152 C CD2 . TYR A 1 146 ? 122.212 15.707 29.400 1.00 28.99 ? 146 TYR A CD2 1 ATOM 1153 C CE1 . TYR A 1 146 ? 120.370 14.107 30.655 1.00 27.46 ? 146 TYR A CE1 1 ATOM 1154 C CE2 . TYR A 1 146 ? 121.901 15.884 30.803 1.00 25.40 ? 146 TYR A CE2 1 ATOM 1155 C CZ . TYR A 1 146 ? 120.972 15.087 31.386 1.00 28.81 ? 146 TYR A CZ 1 ATOM 1156 O OH . TYR A 1 146 ? 120.634 15.273 32.745 1.00 33.16 ? 146 TYR A OH 1 ATOM 1157 N N . ARG A 1 147 ? 119.011 13.849 25.786 1.00 36.65 ? 147 ARG A N 1 ATOM 1158 C CA . ARG A 1 147 ? 117.596 13.534 25.892 1.00 36.33 ? 147 ARG A CA 1 ATOM 1159 C C . ARG A 1 147 ? 117.208 13.104 27.278 1.00 37.09 ? 147 ARG A C 1 ATOM 1160 O O . ARG A 1 147 ? 117.983 12.438 27.963 1.00 37.17 ? 147 ARG A O 1 ATOM 1161 C CB . ARG A 1 147 ? 117.227 12.438 24.913 1.00 36.20 ? 147 ARG A CB 1 ATOM 1162 C CG . ARG A 1 147 ? 117.348 12.843 23.456 1.00 35.86 ? 147 ARG A CG 1 ATOM 1163 C CD . ARG A 1 147 ? 117.197 11.640 22.550 1.00 37.13 ? 147 ARG A CD 1 ATOM 1164 N NE . ARG A 1 147 ? 118.479 11.010 22.282 1.00 37.58 ? 147 ARG A NE 1 ATOM 1165 C CZ . ARG A 1 147 ? 118.645 9.803 21.702 1.00 39.40 ? 147 ARG A CZ 1 ATOM 1166 N NH1 . ARG A 1 147 ? 117.567 9.093 21.326 1.00 36.41 ? 147 ARG A NH1 1 ATOM 1167 N NH2 . ARG A 1 147 ? 119.894 9.325 21.485 1.00 30.21 ? 147 ARG A NH2 1 ATOM 1168 N N . VAL A 1 148 ? 115.978 13.457 27.649 1.00 35.60 ? 148 VAL A N 1 ATOM 1169 C CA . VAL A 1 148 ? 115.483 13.325 28.978 1.00 35.18 ? 148 VAL A CA 1 ATOM 1170 C C . VAL A 1 148 ? 114.073 12.687 28.862 1.00 36.60 ? 148 VAL A C 1 ATOM 1171 O O . VAL A 1 148 ? 113.483 12.609 27.764 1.00 37.60 ? 148 VAL A O 1 ATOM 1172 C CB . VAL A 1 148 ? 115.523 14.728 29.712 1.00 36.50 ? 148 VAL A CB 1 ATOM 1173 C CG1 . VAL A 1 148 ? 116.943 15.118 30.042 1.00 32.16 ? 148 VAL A CG1 1 ATOM 1174 C CG2 . VAL A 1 148 ? 114.845 15.876 28.875 1.00 33.53 ? 148 VAL A CG2 1 ATOM 1175 N N . GLY A 1 149 ? 113.570 12.161 29.954 1.00 35.67 ? 149 GLY A N 1 ATOM 1176 C CA . GLY A 1 149 ? 112.292 11.485 29.954 1.00 35.45 ? 149 GLY A CA 1 ATOM 1177 C C . GLY A 1 149 ? 112.268 10.215 29.144 1.00 36.53 ? 149 GLY A C 1 ATOM 1178 O O . GLY A 1 149 ? 113.287 9.528 29.011 1.00 35.71 ? 149 GLY A O 1 ATOM 1179 N N . ALA A 1 150 ? 111.096 9.881 28.600 1.00 36.91 ? 150 ALA A N 1 ATOM 1180 C CA . ALA A 1 150 ? 110.933 8.620 27.914 1.00 38.45 ? 150 ALA A CA 1 ATOM 1181 C C . ALA A 1 150 ? 111.763 8.666 26.666 1.00 39.01 ? 150 ALA A C 1 ATOM 1182 O O . ALA A 1 150 ? 112.300 7.654 26.269 1.00 40.61 ? 150 ALA A O 1 ATOM 1183 C CB . ALA A 1 150 ? 109.418 8.314 27.566 1.00 39.71 ? 150 ALA A CB 1 ATOM 1184 N N . LEU A 1 151 ? 111.904 9.841 26.066 1.00 39.35 ? 151 LEU A N 1 ATOM 1185 C CA . LEU A 1 151 ? 112.700 9.983 24.852 1.00 40.63 ? 151 LEU A CA 1 ATOM 1186 C C . LEU A 1 151 ? 114.194 9.705 25.054 1.00 41.74 ? 151 LEU A C 1 ATOM 1187 O O . LEU A 1 151 ? 114.918 9.402 24.080 1.00 40.96 ? 151 LEU A O 1 ATOM 1188 C CB . LEU A 1 151 ? 112.525 11.380 24.250 1.00 41.23 ? 151 LEU A CB 1 ATOM 1189 C CG . LEU A 1 151 ? 111.127 11.671 23.641 1.00 43.13 ? 151 LEU A CG 1 ATOM 1190 C CD1 . LEU A 1 151 ? 110.951 13.188 23.427 1.00 41.46 ? 151 LEU A CD1 1 ATOM 1191 C CD2 . LEU A 1 151 ? 110.812 10.846 22.323 1.00 37.52 ? 151 LEU A CD2 1 ATOM 1192 N N . GLY A 1 152 ? 114.653 9.854 26.303 1.00 40.73 ? 152 GLY A N 1 ATOM 1193 C CA . GLY A 1 152 ? 116.026 9.575 26.622 1.00 40.26 ? 152 GLY A CA 1 ATOM 1194 C C . GLY A 1 152 ? 116.247 8.269 27.349 1.00 40.39 ? 152 GLY A C 1 ATOM 1195 O O . GLY A 1 152 ? 117.363 7.782 27.383 1.00 41.45 ? 152 GLY A O 1 ATOM 1196 N N . PHE A 1 153 ? 115.216 7.708 27.956 1.00 41.16 ? 153 PHE A N 1 ATOM 1197 C CA . PHE A 1 153 ? 115.422 6.604 28.867 1.00 42.13 ? 153 PHE A CA 1 ATOM 1198 C C . PHE A 1 153 ? 114.392 5.486 28.865 1.00 43.51 ? 153 PHE A C 1 ATOM 1199 O O . PHE A 1 153 ? 114.405 4.587 29.753 1.00 42.92 ? 153 PHE A O 1 ATOM 1200 C CB . PHE A 1 153 ? 115.594 7.153 30.273 1.00 41.61 ? 153 PHE A CB 1 ATOM 1201 C CG . PHE A 1 153 ? 116.863 7.987 30.469 1.00 40.19 ? 153 PHE A CG 1 ATOM 1202 C CD1 . PHE A 1 153 ? 118.080 7.360 30.777 1.00 36.91 ? 153 PHE A CD1 1 ATOM 1203 C CD2 . PHE A 1 153 ? 116.816 9.404 30.406 1.00 38.17 ? 153 PHE A CD2 1 ATOM 1204 C CE1 . PHE A 1 153 ? 119.258 8.116 31.007 1.00 38.29 ? 153 PHE A CE1 1 ATOM 1205 C CE2 . PHE A 1 153 ? 117.977 10.185 30.636 1.00 36.31 ? 153 PHE A CE2 1 ATOM 1206 C CZ . PHE A 1 153 ? 119.197 9.544 30.940 1.00 37.44 ? 153 PHE A CZ 1 ATOM 1207 N N . LEU A 1 154 ? 113.482 5.533 27.893 1.00 45.29 ? 154 LEU A N 1 ATOM 1208 C CA . LEU A 1 154 ? 112.543 4.433 27.705 1.00 46.92 ? 154 LEU A CA 1 ATOM 1209 C C . LEU A 1 154 ? 113.364 3.143 27.536 1.00 48.24 ? 154 LEU A C 1 ATOM 1210 O O . LEU A 1 154 ? 114.357 3.102 26.789 1.00 47.56 ? 154 LEU A O 1 ATOM 1211 C CB . LEU A 1 154 ? 111.677 4.683 26.476 1.00 47.19 ? 154 LEU A CB 1 ATOM 1212 C CG . LEU A 1 154 ? 110.578 3.694 26.019 1.00 47.95 ? 154 LEU A CG 1 ATOM 1213 C CD1 . LEU A 1 154 ? 109.218 4.251 26.318 1.00 44.97 ? 154 LEU A CD1 1 ATOM 1214 C CD2 . LEU A 1 154 ? 110.713 3.550 24.504 1.00 47.69 ? 154 LEU A CD2 1 ATOM 1215 N N . ALA A 1 155 ? 112.961 2.089 28.224 1.00 49.83 ? 155 ALA A N 1 ATOM 1216 C CA . ALA A 1 155 ? 113.726 0.856 28.105 1.00 52.63 ? 155 ALA A CA 1 ATOM 1217 C C . ALA A 1 155 ? 112.891 -0.404 27.813 1.00 54.33 ? 155 ALA A C 1 ATOM 1218 O O . ALA A 1 155 ? 111.804 -0.608 28.347 1.00 53.18 ? 155 ALA A O 1 ATOM 1219 C CB . ALA A 1 155 ? 114.654 0.662 29.341 1.00 52.51 ? 155 ALA A CB 1 ATOM 1220 N N . LEU A 1 156 ? 113.420 -1.203 26.901 1.00 57.21 ? 156 LEU A N 1 ATOM 1221 C CA . LEU A 1 156 ? 112.947 -2.551 26.667 1.00 59.78 ? 156 LEU A CA 1 ATOM 1222 C C . LEU A 1 156 ? 114.298 -3.242 26.501 1.00 61.37 ? 156 LEU A C 1 ATOM 1223 O O . LEU A 1 156 ? 114.926 -3.162 25.437 1.00 61.86 ? 156 LEU A O 1 ATOM 1224 C CB . LEU A 1 156 ? 112.119 -2.573 25.392 1.00 60.20 ? 156 LEU A CB 1 ATOM 1225 C CG . LEU A 1 156 ? 110.675 -3.082 25.404 1.00 60.77 ? 156 LEU A CG 1 ATOM 1226 C CD1 . LEU A 1 156 ? 109.967 -2.951 26.760 1.00 62.79 ? 156 LEU A CD1 1 ATOM 1227 C CD2 . LEU A 1 156 ? 109.898 -2.350 24.334 1.00 62.56 ? 156 LEU A CD2 1 ATOM 1228 N N . PRO A 1 157 ? 114.788 -3.849 27.586 1.00 62.78 ? 157 PRO A N 1 ATOM 1229 C CA . PRO A 1 157 ? 116.212 -4.242 27.663 1.00 63.42 ? 157 PRO A CA 1 ATOM 1230 C C . PRO A 1 157 ? 116.587 -5.247 26.562 1.00 63.62 ? 157 PRO A C 1 ATOM 1231 O O . PRO A 1 157 ? 115.789 -6.166 26.258 1.00 63.46 ? 157 PRO A O 1 ATOM 1232 C CB . PRO A 1 157 ? 116.337 -4.841 29.076 1.00 63.78 ? 157 PRO A CB 1 ATOM 1233 C CG . PRO A 1 157 ? 115.062 -4.288 29.863 1.00 62.90 ? 157 PRO A CG 1 ATOM 1234 C CD . PRO A 1 157 ? 114.021 -4.218 28.802 1.00 62.95 ? 157 PRO A CD 1 ATOM 1235 N N . GLY A 1 158 ? 117.748 -5.021 25.942 1.00 63.07 ? 158 GLY A N 1 ATOM 1236 C CA . GLY A 1 158 ? 118.249 -5.865 24.856 1.00 63.25 ? 158 GLY A CA 1 ATOM 1237 C C . GLY A 1 158 ? 117.868 -5.466 23.429 1.00 63.75 ? 158 GLY A C 1 ATOM 1238 O O . GLY A 1 158 ? 118.539 -5.853 22.466 1.00 64.38 ? 158 GLY A O 1 ATOM 1239 N N . ASN A 1 159 ? 116.800 -4.674 23.305 1.00 63.26 ? 159 ASN A N 1 ATOM 1240 C CA . ASN A 1 159 ? 116.169 -4.312 22.044 1.00 61.86 ? 159 ASN A CA 1 ATOM 1241 C C . ASN A 1 159 ? 116.688 -2.961 21.603 1.00 61.47 ? 159 ASN A C 1 ATOM 1242 O O . ASN A 1 159 ? 116.322 -1.951 22.227 1.00 61.82 ? 159 ASN A O 1 ATOM 1243 C CB . ASN A 1 159 ? 114.663 -4.231 22.276 1.00 61.86 ? 159 ASN A CB 1 ATOM 1244 C CG . ASN A 1 159 ? 113.880 -3.945 21.017 1.00 61.63 ? 159 ASN A CG 1 ATOM 1245 O OD1 . ASN A 1 159 ? 114.372 -3.292 20.102 1.00 61.82 ? 159 ASN A OD1 1 ATOM 1246 N ND2 . ASN A 1 159 ? 112.638 -4.424 20.971 1.00 61.29 ? 159 ASN A ND2 1 ATOM 1247 N N . PRO A 1 160 ? 117.506 -2.923 20.534 1.00 60.66 ? 160 PRO A N 1 ATOM 1248 C CA . PRO A 1 160 ? 118.215 -1.692 20.140 1.00 59.80 ? 160 PRO A CA 1 ATOM 1249 C C . PRO A 1 160 ? 117.272 -0.583 19.643 1.00 59.82 ? 160 PRO A C 1 ATOM 1250 O O . PRO A 1 160 ? 117.701 0.559 19.388 1.00 60.28 ? 160 PRO A O 1 ATOM 1251 C CB . PRO A 1 160 ? 119.192 -2.160 19.046 1.00 59.92 ? 160 PRO A CB 1 ATOM 1252 C CG . PRO A 1 160 ? 118.676 -3.489 18.559 1.00 59.50 ? 160 PRO A CG 1 ATOM 1253 C CD . PRO A 1 160 ? 117.799 -4.054 19.626 1.00 60.27 ? 160 PRO A CD 1 ATOM 1254 N N . GLU A 1 161 ? 115.996 -0.933 19.515 1.00 59.40 ? 161 GLU A N 1 ATOM 1255 C CA . GLU A 1 161 ? 114.912 0.002 19.172 1.00 58.69 ? 161 GLU A CA 1 ATOM 1256 C C . GLU A 1 161 ? 114.661 0.970 20.302 1.00 56.93 ? 161 GLU A C 1 ATOM 1257 O O . GLU A 1 161 ? 114.320 2.125 20.064 1.00 56.77 ? 161 GLU A O 1 ATOM 1258 C CB . GLU A 1 161 ? 113.610 -0.773 18.886 1.00 58.56 ? 161 GLU A CB 1 ATOM 1259 C CG . GLU A 1 161 ? 113.303 -0.993 17.408 1.00 62.34 ? 161 GLU A CG 1 ATOM 1260 C CD . GLU A 1 161 ? 114.527 -1.257 16.548 1.00 68.09 ? 161 GLU A CD 1 ATOM 1261 O OE1 . GLU A 1 161 ? 114.894 -0.374 15.694 1.00 70.41 ? 161 GLU A OE1 1 ATOM 1262 O OE2 . GLU A 1 161 ? 115.131 -2.347 16.733 1.00 69.58 ? 161 GLU A OE2 1 ATOM 1263 N N . ALA A 1 162 ? 114.811 0.469 21.528 1.00 55.15 ? 162 ALA A N 1 ATOM 1264 C CA . ALA A 1 162 ? 114.619 1.257 22.761 1.00 53.03 ? 162 ALA A CA 1 ATOM 1265 C C . ALA A 1 162 ? 115.431 0.610 23.882 1.00 51.16 ? 162 ALA A C 1 ATOM 1266 O O . ALA A 1 162 ? 114.869 -0.015 24.781 1.00 51.84 ? 162 ALA A O 1 ATOM 1267 C CB . ALA A 1 162 ? 113.145 1.303 23.131 1.00 52.49 ? 162 ALA A CB 1 ATOM 1268 N N . PRO A 1 163 ? 116.755 0.707 23.807 1.00 49.82 ? 163 PRO A N 1 ATOM 1269 C CA . PRO A 1 163 ? 117.600 -0.044 24.720 1.00 48.52 ? 163 PRO A CA 1 ATOM 1270 C C . PRO A 1 163 ? 117.644 0.470 26.161 1.00 47.32 ? 163 PRO A C 1 ATOM 1271 O O . PRO A 1 163 ? 117.963 -0.329 27.069 1.00 48.05 ? 163 PRO A O 1 ATOM 1272 C CB . PRO A 1 163 ? 118.968 -0.024 24.026 1.00 48.10 ? 163 PRO A CB 1 ATOM 1273 C CG . PRO A 1 163 ? 118.969 1.211 23.252 1.00 48.70 ? 163 PRO A CG 1 ATOM 1274 C CD . PRO A 1 163 ? 117.556 1.464 22.827 1.00 49.30 ? 163 PRO A CD 1 ATOM 1275 N N . GLY A 1 164 ? 117.284 1.739 26.390 1.00 44.46 ? 164 GLY A N 1 ATOM 1276 C CA . GLY A 1 164 ? 117.491 2.371 27.687 1.00 41.51 ? 164 GLY A CA 1 ATOM 1277 C C . GLY A 1 164 ? 118.732 3.242 27.632 1.00 40.64 ? 164 GLY A C 1 ATOM 1278 O O . GLY A 1 164 ? 119.567 3.062 26.765 1.00 39.05 ? 164 GLY A O 1 ATOM 1279 N N . ASN A 1 165 ? 118.852 4.231 28.528 1.00 40.05 ? 165 ASN A N 1 ATOM 1280 C CA . ASN A 1 165 ? 120.150 4.952 28.687 1.00 39.36 ? 165 ASN A CA 1 ATOM 1281 C C . ASN A 1 165 ? 120.600 5.812 27.519 1.00 39.25 ? 165 ASN A C 1 ATOM 1282 O O . ASN A 1 165 ? 121.723 6.267 27.483 1.00 40.07 ? 165 ASN A O 1 ATOM 1283 C CB . ASN A 1 165 ? 121.274 3.962 29.094 1.00 37.83 ? 165 ASN A CB 1 ATOM 1284 C CG . ASN A 1 165 ? 121.043 3.400 30.458 1.00 38.25 ? 165 ASN A CG 1 ATOM 1285 O OD1 . ASN A 1 165 ? 120.126 3.855 31.158 1.00 37.72 ? 165 ASN A OD1 1 ATOM 1286 N ND2 . ASN A 1 165 ? 121.825 2.374 30.853 1.00 36.38 ? 165 ASN A ND2 1 ATOM 1287 N N . MET A 1 166 ? 119.711 6.045 26.573 1.00 39.69 ? 166 MET A N 1 ATOM 1288 C CA . MET A 1 166 ? 120.010 6.817 25.409 1.00 39.28 ? 166 MET A CA 1 ATOM 1289 C C . MET A 1 166 ? 120.584 8.203 25.740 1.00 40.03 ? 166 MET A C 1 ATOM 1290 O O . MET A 1 166 ? 121.520 8.690 25.030 1.00 39.40 ? 166 MET A O 1 ATOM 1291 C CB . MET A 1 166 ? 118.725 6.940 24.590 1.00 40.66 ? 166 MET A CB 1 ATOM 1292 C CG . MET A 1 166 ? 118.218 5.615 24.052 1.00 38.43 ? 166 MET A CG 1 ATOM 1293 S SD . MET A 1 166 ? 116.975 4.791 25.081 1.00 43.72 ? 166 MET A SD 1 ATOM 1294 C CE . MET A 1 166 ? 115.482 5.786 24.809 1.00 36.54 ? 166 MET A CE 1 ATOM 1295 N N . GLY A 1 167 ? 120.013 8.852 26.774 1.00 38.96 ? 167 GLY A N 1 ATOM 1296 C CA . GLY A 1 167 ? 120.487 10.171 27.236 1.00 38.69 ? 167 GLY A CA 1 ATOM 1297 C C . GLY A 1 167 ? 121.858 10.128 27.946 1.00 37.97 ? 167 GLY A C 1 ATOM 1298 O O . GLY A 1 167 ? 122.649 11.073 27.899 1.00 38.01 ? 167 GLY A O 1 ATOM 1299 N N . LEU A 1 168 ? 122.171 9.001 28.555 1.00 37.90 ? 168 LEU A N 1 ATOM 1300 C CA . LEU A 1 168 ? 123.566 8.726 28.988 1.00 36.96 ? 168 LEU A CA 1 ATOM 1301 C C . LEU A 1 168 ? 124.507 8.459 27.792 1.00 37.17 ? 168 LEU A C 1 ATOM 1302 O O . LEU A 1 168 ? 125.631 8.995 27.763 1.00 37.28 ? 168 LEU A O 1 ATOM 1303 C CB . LEU A 1 168 ? 123.584 7.614 30.000 1.00 36.72 ? 168 LEU A CB 1 ATOM 1304 C CG . LEU A 1 168 ? 122.944 7.869 31.354 1.00 35.06 ? 168 LEU A CG 1 ATOM 1305 C CD1 . LEU A 1 168 ? 122.817 6.513 32.019 1.00 34.64 ? 168 LEU A CD1 1 ATOM 1306 C CD2 . LEU A 1 168 ? 123.843 8.783 32.141 1.00 36.32 ? 168 LEU A CD2 1 ATOM 1307 N N . PHE A 1 169 ? 124.050 7.715 26.775 1.00 36.41 ? 169 PHE A N 1 ATOM 1308 C CA . PHE A 1 169 ? 124.812 7.681 25.530 1.00 37.20 ? 169 PHE A CA 1 ATOM 1309 C C . PHE A 1 169 ? 124.965 9.050 24.807 1.00 37.33 ? 169 PHE A C 1 ATOM 1310 O O . PHE A 1 169 ? 125.992 9.307 24.166 1.00 38.25 ? 169 PHE A O 1 ATOM 1311 C CB . PHE A 1 169 ? 124.356 6.547 24.597 1.00 38.64 ? 169 PHE A CB 1 ATOM 1312 C CG . PHE A 1 169 ? 124.723 5.155 25.098 1.00 40.10 ? 169 PHE A CG 1 ATOM 1313 C CD1 . PHE A 1 169 ? 123.739 4.281 25.559 1.00 40.58 ? 169 PHE A CD1 1 ATOM 1314 C CD2 . PHE A 1 169 ? 126.047 4.721 25.080 1.00 40.36 ? 169 PHE A CD2 1 ATOM 1315 C CE1 . PHE A 1 169 ? 124.061 2.998 26.020 1.00 44.79 ? 169 PHE A CE1 1 ATOM 1316 C CE2 . PHE A 1 169 ? 126.395 3.402 25.524 1.00 41.12 ? 169 PHE A CE2 1 ATOM 1317 C CZ . PHE A 1 169 ? 125.385 2.540 25.983 1.00 44.05 ? 169 PHE A CZ 1 ATOM 1318 N N . ASP A 1 170 ? 124.005 9.966 24.975 1.00 37.34 ? 170 ASP A N 1 ATOM 1319 C CA . ASP A 1 170 ? 124.156 11.307 24.398 1.00 36.39 ? 170 ASP A CA 1 ATOM 1320 C C . ASP A 1 170 ? 125.330 12.021 25.092 1.00 36.69 ? 170 ASP A C 1 ATOM 1321 O O . ASP A 1 170 ? 126.182 12.642 24.428 1.00 37.00 ? 170 ASP A O 1 ATOM 1322 C CB . ASP A 1 170 ? 122.883 12.168 24.575 1.00 34.57 ? 170 ASP A CB 1 ATOM 1323 C CG . ASP A 1 170 ? 121.678 11.637 23.815 1.00 38.14 ? 170 ASP A CG 1 ATOM 1324 O OD1 . ASP A 1 170 ? 121.818 10.836 22.863 1.00 38.64 ? 170 ASP A OD1 1 ATOM 1325 O OD2 . ASP A 1 170 ? 120.513 11.925 24.148 1.00 37.92 ? 170 ASP A OD2 1 ATOM 1326 N N . GLN A 1 171 ? 125.319 11.997 26.438 1.00 36.17 ? 171 GLN A N 1 ATOM 1327 C CA . GLN A 1 171 ? 126.380 12.575 27.214 1.00 35.79 ? 171 GLN A CA 1 ATOM 1328 C C . GLN A 1 171 ? 127.670 11.947 26.701 1.00 36.07 ? 171 GLN A C 1 ATOM 1329 O O . GLN A 1 171 ? 128.566 12.653 26.320 1.00 37.50 ? 171 GLN A O 1 ATOM 1330 C CB . GLN A 1 171 ? 126.181 12.329 28.692 1.00 34.63 ? 171 GLN A CB 1 ATOM 1331 C CG . GLN A 1 171 ? 124.903 12.901 29.303 1.00 35.66 ? 171 GLN A CG 1 ATOM 1332 C CD . GLN A 1 171 ? 124.757 12.445 30.728 1.00 37.85 ? 171 GLN A CD 1 ATOM 1333 O OE1 . GLN A 1 171 ? 125.735 11.923 31.318 1.00 36.11 ? 171 GLN A OE1 1 ATOM 1334 N NE2 . GLN A 1 171 ? 123.562 12.621 31.302 1.00 36.04 ? 171 GLN A NE2 1 ATOM 1335 N N . GLN A 1 172 ? 127.725 10.631 26.598 1.00 37.44 ? 172 GLN A N 1 ATOM 1336 C CA . GLN A 1 172 ? 128.975 9.965 26.249 1.00 39.31 ? 172 GLN A CA 1 ATOM 1337 C C . GLN A 1 172 ? 129.508 10.377 24.890 1.00 40.32 ? 172 GLN A C 1 ATOM 1338 O O . GLN A 1 172 ? 130.691 10.641 24.725 1.00 40.66 ? 172 GLN A O 1 ATOM 1339 C CB . GLN A 1 172 ? 128.816 8.463 26.338 1.00 38.86 ? 172 GLN A CB 1 ATOM 1340 C CG . GLN A 1 172 ? 130.143 7.748 26.416 1.00 40.46 ? 172 GLN A CG 1 ATOM 1341 C CD . GLN A 1 172 ? 129.952 6.248 26.342 1.00 41.24 ? 172 GLN A CD 1 ATOM 1342 O OE1 . GLN A 1 172 ? 129.992 5.558 27.360 1.00 43.42 ? 172 GLN A OE1 1 ATOM 1343 N NE2 . GLN A 1 172 ? 129.697 5.750 25.153 1.00 39.56 ? 172 GLN A NE2 1 ATOM 1344 N N . LEU A 1 173 ? 128.626 10.453 23.905 1.00 41.77 ? 173 LEU A N 1 ATOM 1345 C CA . LEU A 1 173 ? 129.026 10.879 22.588 1.00 41.22 ? 173 LEU A CA 1 ATOM 1346 C C . LEU A 1 173 ? 129.485 12.337 22.618 1.00 41.74 ? 173 LEU A C 1 ATOM 1347 O O . LEU A 1 173 ? 130.363 12.727 21.829 1.00 42.28 ? 173 LEU A O 1 ATOM 1348 C CB . LEU A 1 173 ? 127.868 10.679 21.589 1.00 42.89 ? 173 LEU A CB 1 ATOM 1349 C CG . LEU A 1 173 ? 128.136 11.010 20.108 1.00 43.84 ? 173 LEU A CG 1 ATOM 1350 C CD1 . LEU A 1 173 ? 129.333 10.176 19.629 1.00 45.52 ? 173 LEU A CD1 1 ATOM 1351 C CD2 . LEU A 1 173 ? 126.912 10.736 19.221 1.00 43.63 ? 173 LEU A CD2 1 ATOM 1352 N N . ALA A 1 174 ? 128.947 13.161 23.520 1.00 40.76 ? 174 ALA A N 1 ATOM 1353 C CA . ALA A 1 174 ? 129.541 14.477 23.638 1.00 40.84 ? 174 ALA A CA 1 ATOM 1354 C C . ALA A 1 174 ? 130.958 14.465 24.258 1.00 41.65 ? 174 ALA A C 1 ATOM 1355 O O . ALA A 1 174 ? 131.805 15.273 23.842 1.00 41.47 ? 174 ALA A O 1 ATOM 1356 C CB . ALA A 1 174 ? 128.646 15.441 24.367 1.00 41.32 ? 174 ALA A CB 1 ATOM 1357 N N . LEU A 1 175 ? 131.202 13.611 25.271 1.00 41.19 ? 175 LEU A N 1 ATOM 1358 C CA . LEU A 1 175 ? 132.576 13.391 25.789 1.00 41.58 ? 175 LEU A CA 1 ATOM 1359 C C . LEU A 1 175 ? 133.576 12.970 24.666 1.00 41.24 ? 175 LEU A C 1 ATOM 1360 O O . LEU A 1 175 ? 134.702 13.433 24.643 1.00 41.00 ? 175 LEU A O 1 ATOM 1361 C CB . LEU A 1 175 ? 132.588 12.389 26.968 1.00 41.86 ? 175 LEU A CB 1 ATOM 1362 C CG . LEU A 1 175 ? 131.519 12.516 28.049 1.00 42.41 ? 175 LEU A CG 1 ATOM 1363 C CD1 . LEU A 1 175 ? 131.714 11.455 29.161 1.00 44.08 ? 175 LEU A CD1 1 ATOM 1364 C CD2 . LEU A 1 175 ? 131.429 13.914 28.624 1.00 43.12 ? 175 LEU A CD2 1 ATOM 1365 N N A GLN A 1 176 ? 133.149 12.111 23.749 0.50 41.50 ? 176 GLN A N 1 ATOM 1366 N N B GLN A 1 176 ? 133.105 12.109 23.766 0.50 41.58 ? 176 GLN A N 1 ATOM 1367 C CA A GLN A 1 176 ? 133.961 11.774 22.578 0.50 41.94 ? 176 GLN A CA 1 ATOM 1368 C CA B GLN A 1 176 ? 133.759 11.677 22.518 0.50 42.03 ? 176 GLN A CA 1 ATOM 1369 C C A GLN A 1 176 ? 134.261 12.980 21.698 0.50 42.62 ? 176 GLN A C 1 ATOM 1370 C C B GLN A 1 176 ? 134.166 12.850 21.618 0.50 42.69 ? 176 GLN A C 1 ATOM 1371 O O A GLN A 1 176 ? 135.415 13.194 21.288 0.50 42.97 ? 176 GLN A O 1 ATOM 1372 O O B GLN A 1 176 ? 135.298 12.907 21.119 0.50 43.31 ? 176 GLN A O 1 ATOM 1373 C CB A GLN A 1 176 ? 133.311 10.675 21.744 0.50 41.98 ? 176 GLN A CB 1 ATOM 1374 C CB B GLN A 1 176 ? 132.763 10.782 21.770 0.50 42.22 ? 176 GLN A CB 1 ATOM 1375 C CG A GLN A 1 176 ? 133.964 9.287 21.905 0.50 44.63 ? 176 GLN A CG 1 ATOM 1376 C CG B GLN A 1 176 ? 133.301 9.706 20.844 0.50 44.57 ? 176 GLN A CG 1 ATOM 1377 C CD A GLN A 1 176 ? 135.360 9.175 21.266 0.50 45.04 ? 176 GLN A CD 1 ATOM 1378 C CD B GLN A 1 176 ? 132.460 8.418 20.917 0.50 47.74 ? 176 GLN A CD 1 ATOM 1379 O OE1 A GLN A 1 176 ? 136.019 8.146 21.389 0.50 46.37 ? 176 GLN A OE1 1 ATOM 1380 O OE1 B GLN A 1 176 ? 132.225 7.870 22.011 0.50 47.07 ? 176 GLN A OE1 1 ATOM 1381 N NE2 A GLN A 1 176 ? 135.804 10.233 20.608 0.50 43.66 ? 176 GLN A NE2 1 ATOM 1382 N NE2 B GLN A 1 176 ? 132.027 7.924 19.755 0.50 47.84 ? 176 GLN A NE2 1 ATOM 1383 N N . TRP A 1 177 ? 133.236 13.787 21.420 1.00 42.87 ? 177 TRP A N 1 ATOM 1384 C CA . TRP A 1 177 ? 133.439 14.976 20.611 1.00 42.82 ? 177 TRP A CA 1 ATOM 1385 C C . TRP A 1 177 ? 134.579 15.821 21.222 1.00 43.15 ? 177 TRP A C 1 ATOM 1386 O O . TRP A 1 177 ? 135.425 16.325 20.507 1.00 42.98 ? 177 TRP A O 1 ATOM 1387 C CB . TRP A 1 177 ? 132.126 15.791 20.521 1.00 42.50 ? 177 TRP A CB 1 ATOM 1388 C CG . TRP A 1 177 ? 132.256 17.059 19.670 1.00 42.85 ? 177 TRP A CG 1 ATOM 1389 C CD1 . TRP A 1 177 ? 131.896 17.206 18.345 1.00 41.18 ? 177 TRP A CD1 1 ATOM 1390 C CD2 . TRP A 1 177 ? 132.806 18.326 20.070 1.00 40.72 ? 177 TRP A CD2 1 ATOM 1391 N NE1 . TRP A 1 177 ? 132.183 18.482 17.912 1.00 40.14 ? 177 TRP A NE1 1 ATOM 1392 C CE2 . TRP A 1 177 ? 132.729 19.198 18.943 1.00 40.38 ? 177 TRP A CE2 1 ATOM 1393 C CE3 . TRP A 1 177 ? 133.299 18.838 21.273 1.00 42.05 ? 177 TRP A CE3 1 ATOM 1394 C CZ2 . TRP A 1 177 ? 133.203 20.516 18.965 1.00 37.62 ? 177 TRP A CZ2 1 ATOM 1395 C CZ3 . TRP A 1 177 ? 133.759 20.172 21.304 1.00 42.88 ? 177 TRP A CZ3 1 ATOM 1396 C CH2 . TRP A 1 177 ? 133.698 20.998 20.141 1.00 41.24 ? 177 TRP A CH2 1 ATOM 1397 N N . VAL A 1 178 ? 134.559 16.010 22.542 1.00 43.82 ? 178 VAL A N 1 ATOM 1398 C CA . VAL A 1 178 ? 135.626 16.745 23.247 1.00 44.89 ? 178 VAL A CA 1 ATOM 1399 C C . VAL A 1 178 ? 136.975 16.008 23.064 1.00 44.87 ? 178 VAL A C 1 ATOM 1400 O O . VAL A 1 178 ? 137.955 16.612 22.690 1.00 44.11 ? 178 VAL A O 1 ATOM 1401 C CB . VAL A 1 178 ? 135.288 16.940 24.781 1.00 45.28 ? 178 VAL A CB 1 ATOM 1402 C CG1 . VAL A 1 178 ? 136.446 17.530 25.530 1.00 45.14 ? 178 VAL A CG1 1 ATOM 1403 C CG2 . VAL A 1 178 ? 134.059 17.807 24.955 1.00 44.44 ? 178 VAL A CG2 1 ATOM 1404 N N . GLN A 1 179 ? 137.009 14.701 23.332 1.00 45.99 ? 179 GLN A N 1 ATOM 1405 C CA . GLN A 1 179 ? 138.189 13.864 22.988 1.00 46.06 ? 179 GLN A CA 1 ATOM 1406 C C . GLN A 1 179 ? 138.748 14.186 21.559 1.00 46.33 ? 179 GLN A C 1 ATOM 1407 O O . GLN A 1 179 ? 139.900 14.621 21.425 1.00 45.50 ? 179 GLN A O 1 ATOM 1408 C CB . GLN A 1 179 ? 137.896 12.360 23.206 1.00 44.75 ? 179 GLN A CB 1 ATOM 1409 C CG . GLN A 1 179 ? 137.876 11.926 24.685 1.00 45.14 ? 179 GLN A CG 1 ATOM 1410 C CD . GLN A 1 179 ? 139.075 12.487 25.500 1.00 44.40 ? 179 GLN A CD 1 ATOM 1411 O OE1 . GLN A 1 179 ? 140.179 12.004 25.361 1.00 43.24 ? 179 GLN A OE1 1 ATOM 1412 N NE2 . GLN A 1 179 ? 138.844 13.500 26.318 1.00 42.93 ? 179 GLN A NE2 1 ATOM 1413 N N . LYS A 1 180 ? 137.923 14.022 20.519 1.00 47.17 ? 180 LYS A N 1 ATOM 1414 C CA . LYS A 1 180 ? 138.376 14.245 19.126 1.00 48.41 ? 180 LYS A CA 1 ATOM 1415 C C . LYS A 1 180 ? 138.585 15.695 18.705 1.00 48.15 ? 180 LYS A C 1 ATOM 1416 O O . LYS A 1 180 ? 139.322 15.925 17.750 1.00 48.48 ? 180 LYS A O 1 ATOM 1417 C CB . LYS A 1 180 ? 137.406 13.637 18.120 1.00 49.03 ? 180 LYS A CB 1 ATOM 1418 C CG . LYS A 1 180 ? 137.224 12.129 18.183 1.00 53.05 ? 180 LYS A CG 1 ATOM 1419 C CD . LYS A 1 180 ? 135.826 11.819 17.599 1.00 57.43 ? 180 LYS A CD 1 ATOM 1420 C CE . LYS A 1 180 ? 135.756 10.534 16.791 1.00 59.83 ? 180 LYS A CE 1 ATOM 1421 N NZ . LYS A 1 180 ? 135.461 9.369 17.644 1.00 61.77 ? 180 LYS A NZ 1 ATOM 1422 N N . ASN A 1 181 ? 137.933 16.663 19.369 1.00 47.05 ? 181 ASN A N 1 ATOM 1423 C CA . ASN A 1 181 ? 137.866 18.037 18.849 1.00 46.57 ? 181 ASN A CA 1 ATOM 1424 C C . ASN A 1 181 ? 138.401 19.142 19.729 1.00 45.97 ? 181 ASN A C 1 ATOM 1425 O O . ASN A 1 181 ? 138.673 20.230 19.237 1.00 45.74 ? 181 ASN A O 1 ATOM 1426 C CB . ASN A 1 181 ? 136.420 18.423 18.474 1.00 46.43 ? 181 ASN A CB 1 ATOM 1427 C CG . ASN A 1 181 ? 135.903 17.667 17.263 1.00 47.70 ? 181 ASN A CG 1 ATOM 1428 O OD1 . ASN A 1 181 ? 136.177 18.040 16.121 1.00 51.51 ? 181 ASN A OD1 1 ATOM 1429 N ND2 . ASN A 1 181 ? 135.119 16.629 17.501 1.00 44.40 ? 181 ASN A ND2 1 ATOM 1430 N N . ILE A 1 182 ? 138.509 18.918 21.025 1.00 45.00 ? 182 ILE A N 1 ATOM 1431 C CA . ILE A 1 182 ? 138.865 20.056 21.890 1.00 45.40 ? 182 ILE A CA 1 ATOM 1432 C C . ILE A 1 182 ? 140.291 20.608 21.694 1.00 46.08 ? 182 ILE A C 1 ATOM 1433 O O . ILE A 1 182 ? 140.521 21.772 21.946 1.00 46.79 ? 182 ILE A O 1 ATOM 1434 C CB . ILE A 1 182 ? 138.553 19.756 23.393 1.00 45.24 ? 182 ILE A CB 1 ATOM 1435 C CG1 . ILE A 1 182 ? 138.034 20.999 24.129 1.00 44.93 ? 182 ILE A CG1 1 ATOM 1436 C CG2 . ILE A 1 182 ? 139.702 19.026 24.097 1.00 43.59 ? 182 ILE A CG2 1 ATOM 1437 C CD1 . ILE A 1 182 ? 136.576 21.278 23.784 1.00 45.75 ? 182 ILE A CD1 1 ATOM 1438 N N . ALA A 1 183 ? 141.254 19.801 21.259 1.00 47.62 ? 183 ALA A N 1 ATOM 1439 C CA . ALA A 1 183 ? 142.614 20.367 21.004 1.00 48.55 ? 183 ALA A CA 1 ATOM 1440 C C . ALA A 1 183 ? 142.579 21.566 20.060 1.00 48.69 ? 183 ALA A C 1 ATOM 1441 O O . ALA A 1 183 ? 143.230 22.563 20.325 1.00 49.82 ? 183 ALA A O 1 ATOM 1442 C CB . ALA A 1 183 ? 143.568 19.301 20.496 1.00 48.84 ? 183 ALA A CB 1 ATOM 1443 N N . ALA A 1 184 ? 141.762 21.483 19.005 1.00 49.34 ? 184 ALA A N 1 ATOM 1444 C CA . ALA A 1 184 ? 141.497 22.587 18.062 1.00 49.52 ? 184 ALA A CA 1 ATOM 1445 C C . ALA A 1 184 ? 141.032 23.933 18.666 1.00 49.89 ? 184 ALA A C 1 ATOM 1446 O O . ALA A 1 184 ? 141.301 25.031 18.107 1.00 50.96 ? 184 ALA A O 1 ATOM 1447 C CB . ALA A 1 184 ? 140.523 22.114 16.970 1.00 50.17 ? 184 ALA A CB 1 ATOM 1448 N N . PHE A 1 185 ? 140.360 23.860 19.813 1.00 48.74 ? 185 PHE A N 1 ATOM 1449 C CA . PHE A 1 185 ? 139.922 25.049 20.561 1.00 46.74 ? 185 PHE A CA 1 ATOM 1450 C C . PHE A 1 185 ? 140.969 25.482 21.568 1.00 46.01 ? 185 PHE A C 1 ATOM 1451 O O . PHE A 1 185 ? 140.787 26.457 22.256 1.00 45.27 ? 185 PHE A O 1 ATOM 1452 C CB . PHE A 1 185 ? 138.592 24.778 21.273 1.00 46.42 ? 185 PHE A CB 1 ATOM 1453 C CG . PHE A 1 185 ? 137.472 24.515 20.330 1.00 44.99 ? 185 PHE A CG 1 ATOM 1454 C CD1 . PHE A 1 185 ? 137.339 23.270 19.750 1.00 43.49 ? 185 PHE A CD1 1 ATOM 1455 C CD2 . PHE A 1 185 ? 136.588 25.545 19.977 1.00 41.92 ? 185 PHE A CD2 1 ATOM 1456 C CE1 . PHE A 1 185 ? 136.334 23.036 18.835 1.00 47.57 ? 185 PHE A CE1 1 ATOM 1457 C CE2 . PHE A 1 185 ? 135.590 25.341 19.057 1.00 42.73 ? 185 PHE A CE2 1 ATOM 1458 C CZ . PHE A 1 185 ? 135.442 24.098 18.485 1.00 47.16 ? 185 PHE A CZ 1 ATOM 1459 N N . GLY A 1 186 ? 142.074 24.751 21.617 1.00 45.85 ? 186 GLY A N 1 ATOM 1460 C CA . GLY A 1 186 ? 143.125 25.002 22.601 1.00 45.66 ? 186 GLY A CA 1 ATOM 1461 C C . GLY A 1 186 ? 142.934 24.251 23.919 1.00 45.47 ? 186 GLY A C 1 ATOM 1462 O O . GLY A 1 186 ? 143.437 24.694 24.959 1.00 45.52 ? 186 GLY A O 1 ATOM 1463 N N . GLY A 1 187 ? 142.242 23.109 23.882 1.00 44.72 ? 187 GLY A N 1 ATOM 1464 C CA . GLY A 1 187 ? 141.948 22.384 25.112 1.00 45.10 ? 187 GLY A CA 1 ATOM 1465 C C . GLY A 1 187 ? 142.817 21.160 25.210 1.00 44.90 ? 187 GLY A C 1 ATOM 1466 O O . GLY A 1 187 ? 143.271 20.641 24.202 1.00 45.23 ? 187 GLY A O 1 ATOM 1467 N N . ASN A 1 188 ? 143.051 20.685 26.427 1.00 44.65 ? 188 ASN A N 1 ATOM 1468 C CA . ASN A 1 188 ? 143.717 19.395 26.610 1.00 42.73 ? 188 ASN A CA 1 ATOM 1469 C C . ASN A 1 188 ? 142.763 18.213 26.789 1.00 42.72 ? 188 ASN A C 1 ATOM 1470 O O . ASN A 1 188 ? 142.193 18.055 27.840 1.00 42.44 ? 188 ASN A O 1 ATOM 1471 C CB . ASN A 1 188 ? 144.582 19.523 27.845 1.00 43.76 ? 188 ASN A CB 1 ATOM 1472 C CG . ASN A 1 188 ? 145.461 18.337 28.058 1.00 40.69 ? 188 ASN A CG 1 ATOM 1473 O OD1 . ASN A 1 188 ? 145.458 17.368 27.294 1.00 44.07 ? 188 ASN A OD1 1 ATOM 1474 N ND2 . ASN A 1 188 ? 146.211 18.398 29.106 1.00 38.82 ? 188 ASN A ND2 1 ATOM 1475 N N . PRO A 1 189 ? 142.621 17.332 25.804 1.00 43.36 ? 189 PRO A N 1 ATOM 1476 C CA . PRO A 1 189 ? 141.758 16.174 25.986 1.00 43.66 ? 189 PRO A CA 1 ATOM 1477 C C . PRO A 1 189 ? 142.168 15.266 27.167 1.00 44.27 ? 189 PRO A C 1 ATOM 1478 O O . PRO A 1 189 ? 141.332 14.467 27.622 1.00 45.10 ? 189 PRO A O 1 ATOM 1479 C CB . PRO A 1 189 ? 141.908 15.403 24.657 1.00 43.14 ? 189 PRO A CB 1 ATOM 1480 C CG . PRO A 1 189 ? 143.168 15.874 24.088 1.00 43.33 ? 189 PRO A CG 1 ATOM 1481 C CD . PRO A 1 189 ? 143.281 17.325 24.481 1.00 42.99 ? 189 PRO A CD 1 ATOM 1482 N N . LYS A 1 190 ? 143.426 15.386 27.640 1.00 44.24 ? 190 LYS A N 1 ATOM 1483 C CA . LYS A 1 190 ? 143.974 14.546 28.723 1.00 43.66 ? 190 LYS A CA 1 ATOM 1484 C C . LYS A 1 190 ? 143.710 15.153 30.092 1.00 42.41 ? 190 LYS A C 1 ATOM 1485 O O . LYS A 1 190 ? 144.039 14.553 31.097 1.00 41.56 ? 190 LYS A O 1 ATOM 1486 C CB . LYS A 1 190 ? 145.494 14.386 28.568 1.00 44.74 ? 190 LYS A CB 1 ATOM 1487 C CG . LYS A 1 190 ? 145.948 13.355 27.513 1.00 47.79 ? 190 LYS A CG 1 ATOM 1488 C CD . LYS A 1 190 ? 147.470 13.572 27.132 1.00 52.61 ? 190 LYS A CD 1 ATOM 1489 C CE . LYS A 1 190 ? 147.973 12.429 26.216 1.00 56.23 ? 190 LYS A CE 1 ATOM 1490 N NZ . LYS A 1 190 ? 149.487 12.215 26.222 1.00 60.15 ? 190 LYS A NZ 1 ATOM 1491 N N . SER A 1 191 ? 143.116 16.348 30.125 1.00 40.38 ? 191 SER A N 1 ATOM 1492 C CA . SER A 1 191 ? 142.739 16.999 31.364 1.00 38.05 ? 191 SER A CA 1 ATOM 1493 C C . SER A 1 191 ? 141.269 17.469 31.244 1.00 38.14 ? 191 SER A C 1 ATOM 1494 O O . SER A 1 191 ? 140.970 18.664 31.050 1.00 38.98 ? 191 SER A O 1 ATOM 1495 C CB . SER A 1 191 ? 143.709 18.121 31.664 1.00 37.40 ? 191 SER A CB 1 ATOM 1496 O OG . SER A 1 191 ? 143.455 18.723 32.922 1.00 37.58 ? 191 SER A OG 1 ATOM 1497 N N . VAL A 1 192 ? 140.359 16.509 31.341 1.00 36.84 ? 192 VAL A N 1 ATOM 1498 C CA . VAL A 1 192 ? 138.920 16.754 31.245 1.00 36.65 ? 192 VAL A CA 1 ATOM 1499 C C . VAL A 1 192 ? 138.232 16.406 32.566 1.00 36.00 ? 192 VAL A C 1 ATOM 1500 O O . VAL A 1 192 ? 138.285 15.264 32.984 1.00 36.83 ? 192 VAL A O 1 ATOM 1501 C CB . VAL A 1 192 ? 138.293 15.907 30.134 1.00 36.93 ? 192 VAL A CB 1 ATOM 1502 C CG1 . VAL A 1 192 ? 136.742 16.051 30.138 1.00 37.49 ? 192 VAL A CG1 1 ATOM 1503 C CG2 . VAL A 1 192 ? 138.880 16.298 28.759 1.00 37.51 ? 192 VAL A CG2 1 ATOM 1504 N N . THR A 1 193 ? 137.567 17.362 33.203 1.00 34.74 ? 193 THR A N 1 ATOM 1505 C CA . THR A 1 193 ? 136.815 17.046 34.418 1.00 35.33 ? 193 THR A CA 1 ATOM 1506 C C . THR A 1 193 ? 135.320 17.162 34.150 1.00 35.00 ? 193 THR A C 1 ATOM 1507 O O . THR A 1 193 ? 134.888 18.150 33.614 1.00 33.45 ? 193 THR A O 1 ATOM 1508 C CB . THR A 1 193 ? 137.230 18.004 35.540 1.00 35.46 ? 193 THR A CB 1 ATOM 1509 O OG1 . THR A 1 193 ? 138.589 17.712 35.879 1.00 37.03 ? 193 THR A OG1 1 ATOM 1510 C CG2 . THR A 1 193 ? 136.426 17.826 36.820 1.00 34.09 ? 193 THR A CG2 1 ATOM 1511 N N . LEU A 1 194 ? 134.555 16.113 34.493 1.00 34.91 ? 194 LEU A N 1 ATOM 1512 C CA . LEU A 1 194 ? 133.105 16.175 34.424 1.00 34.88 ? 194 LEU A CA 1 ATOM 1513 C C . LEU A 1 194 ? 132.616 16.754 35.721 1.00 34.72 ? 194 LEU A C 1 ATOM 1514 O O . LEU A 1 194 ? 133.106 16.360 36.793 1.00 35.80 ? 194 LEU A O 1 ATOM 1515 C CB . LEU A 1 194 ? 132.499 14.771 34.255 1.00 34.19 ? 194 LEU A CB 1 ATOM 1516 C CG . LEU A 1 194 ? 133.077 13.827 33.197 1.00 35.56 ? 194 LEU A CG 1 ATOM 1517 C CD1 . LEU A 1 194 ? 132.374 12.462 33.284 1.00 34.54 ? 194 LEU A CD1 1 ATOM 1518 C CD2 . LEU A 1 194 ? 133.105 14.395 31.705 1.00 33.89 ? 194 LEU A CD2 1 ATOM 1519 N N . PHE A 1 195 ? 131.657 17.674 35.634 1.00 34.45 ? 195 PHE A N 1 ATOM 1520 C CA . PHE A 1 195 ? 130.891 18.110 36.781 1.00 33.95 ? 195 PHE A CA 1 ATOM 1521 C C . PHE A 1 195 ? 129.405 18.208 36.448 1.00 35.40 ? 195 PHE A C 1 ATOM 1522 O O . PHE A 1 195 ? 129.049 18.361 35.260 1.00 35.63 ? 195 PHE A O 1 ATOM 1523 C CB . PHE A 1 195 ? 131.501 19.350 37.476 1.00 34.11 ? 195 PHE A CB 1 ATOM 1524 C CG . PHE A 1 195 ? 131.416 20.652 36.723 1.00 33.14 ? 195 PHE A CG 1 ATOM 1525 C CD1 . PHE A 1 195 ? 131.692 20.753 35.386 1.00 33.22 ? 195 PHE A CD1 1 ATOM 1526 C CD2 . PHE A 1 195 ? 131.152 21.818 37.422 1.00 32.96 ? 195 PHE A CD2 1 ATOM 1527 C CE1 . PHE A 1 195 ? 131.610 22.012 34.751 1.00 32.48 ? 195 PHE A CE1 1 ATOM 1528 C CE2 . PHE A 1 195 ? 131.074 23.031 36.809 1.00 34.21 ? 195 PHE A CE2 1 ATOM 1529 C CZ . PHE A 1 195 ? 131.308 23.125 35.452 1.00 33.46 ? 195 PHE A CZ 1 ATOM 1530 N N . GLY A 1 196 ? 128.542 18.061 37.473 1.00 35.08 ? 196 GLY A N 1 ATOM 1531 C CA . GLY A 1 196 ? 127.101 18.054 37.273 1.00 34.13 ? 196 GLY A CA 1 ATOM 1532 C C . GLY A 1 196 ? 126.423 18.097 38.622 1.00 35.28 ? 196 GLY A C 1 ATOM 1533 O O . GLY A 1 196 ? 127.078 17.840 39.629 1.00 34.64 ? 196 GLY A O 1 ATOM 1534 N N . GLU A 1 197 ? 125.131 18.449 38.647 1.00 34.36 ? 197 GLU A N 1 ATOM 1535 C CA . GLU A 1 197 ? 124.381 18.552 39.883 1.00 34.54 ? 197 GLU A CA 1 ATOM 1536 C C . GLU A 1 197 ? 123.155 17.633 39.845 1.00 34.81 ? 197 GLU A C 1 ATOM 1537 O O . GLU A 1 197 ? 122.561 17.443 38.773 1.00 36.02 ? 197 GLU A O 1 ATOM 1538 C CB . GLU A 1 197 ? 124.005 20.027 40.149 1.00 34.12 ? 197 GLU A CB 1 ATOM 1539 C CG . GLU A 1 197 ? 123.323 20.295 41.477 1.00 33.48 ? 197 GLU A CG 1 ATOM 1540 C CD . GLU A 1 197 ? 121.796 20.330 41.367 1.00 37.94 ? 197 GLU A CD 1 ATOM 1541 O OE1 . GLU A 1 197 ? 121.300 20.281 40.192 1.00 34.36 ? 197 GLU A OE1 1 ATOM 1542 O OE2 . GLU A 1 197 ? 121.098 20.426 42.431 1.00 36.00 ? 197 GLU A OE2 1 ATOM 1543 N N . SER A 1 198 ? 122.809 17.036 40.992 1.00 34.65 ? 198 SER A N 1 ATOM 1544 C CA . SER A 1 198 ? 121.652 16.110 41.097 1.00 34.51 ? 198 SER A CA 1 ATOM 1545 C C . SER A 1 198 ? 121.678 15.016 40.002 1.00 34.14 ? 198 SER A C 1 ATOM 1546 O O . SER A 1 198 ? 122.658 14.270 39.878 1.00 35.18 ? 198 SER A O 1 ATOM 1547 C CB . SER A 1 198 ? 120.357 16.914 41.080 1.00 34.46 ? 198 SER A CB 1 ATOM 1548 O OG . SER A 1 198 ? 119.073 16.401 41.452 1.00 42.32 ? 198 SER A OG 1 ATOM 1549 N N . ALA A 1 199 ? 120.661 14.934 39.158 1.00 32.69 ? 199 ALA A N 1 ATOM 1550 C CA . ALA A 1 199 ? 120.731 13.926 38.057 1.00 31.22 ? 199 ALA A CA 1 ATOM 1551 C C . ALA A 1 199 ? 121.964 14.054 37.171 1.00 30.01 ? 199 ALA A C 1 ATOM 1552 O O . ALA A 1 199 ? 122.440 13.032 36.606 1.00 29.92 ? 199 ALA A O 1 ATOM 1553 C CB . ALA A 1 199 ? 119.421 13.891 37.208 1.00 29.66 ? 199 ALA A CB 1 ATOM 1554 N N . GLY A 1 200 ? 122.483 15.289 37.037 1.00 29.79 ? 200 GLY A N 1 ATOM 1555 C CA . GLY A 1 200 ? 123.738 15.516 36.314 1.00 30.46 ? 200 GLY A CA 1 ATOM 1556 C C . GLY A 1 200 ? 124.913 14.892 37.089 1.00 31.24 ? 200 GLY A C 1 ATOM 1557 O O . GLY A 1 200 ? 125.824 14.324 36.480 1.00 32.25 ? 200 GLY A O 1 ATOM 1558 N N . ALA A 1 201 ? 124.857 14.963 38.427 1.00 31.39 ? 201 ALA A N 1 ATOM 1559 C CA . ALA A 1 201 ? 125.874 14.386 39.346 1.00 31.94 ? 201 ALA A CA 1 ATOM 1560 C C . ALA A 1 201 ? 125.757 12.860 39.366 1.00 33.20 ? 201 ALA A C 1 ATOM 1561 O O . ALA A 1 201 ? 126.767 12.169 39.197 1.00 33.80 ? 201 ALA A O 1 ATOM 1562 C CB . ALA A 1 201 ? 125.692 14.941 40.755 1.00 31.25 ? 201 ALA A CB 1 ATOM 1563 N N . ALA A 1 202 ? 124.537 12.328 39.558 1.00 32.70 ? 202 ALA A N 1 ATOM 1564 C CA . ALA A 1 202 ? 124.309 10.899 39.289 1.00 32.72 ? 202 ALA A CA 1 ATOM 1565 C C . ALA A 1 202 ? 124.873 10.419 37.925 1.00 33.73 ? 202 ALA A C 1 ATOM 1566 O O . ALA A 1 202 ? 125.468 9.328 37.830 1.00 34.66 ? 202 ALA A O 1 ATOM 1567 C CB . ALA A 1 202 ? 122.822 10.565 39.397 1.00 31.84 ? 202 ALA A CB 1 ATOM 1568 N N . SER A 1 203 ? 124.666 11.194 36.862 1.00 33.33 ? 203 SER A N 1 ATOM 1569 C CA . SER A 1 203 ? 125.211 10.846 35.571 1.00 33.87 ? 203 SER A CA 1 ATOM 1570 C C . SER A 1 203 ? 126.718 10.773 35.692 1.00 34.42 ? 203 SER A C 1 ATOM 1571 O O . SER A 1 203 ? 127.311 9.865 35.200 1.00 35.23 ? 203 SER A O 1 ATOM 1572 C CB . SER A 1 203 ? 124.853 11.887 34.506 1.00 33.19 ? 203 SER A CB 1 ATOM 1573 O OG . SER A 1 203 ? 123.441 11.983 34.276 1.00 37.14 ? 203 SER A OG 1 ATOM 1574 N N . VAL A 1 204 ? 127.338 11.749 36.351 1.00 34.96 ? 204 VAL A N 1 ATOM 1575 C CA . VAL A 1 204 ? 128.789 11.776 36.431 1.00 34.33 ? 204 VAL A CA 1 ATOM 1576 C C . VAL A 1 204 ? 129.209 10.470 37.131 1.00 34.68 ? 204 VAL A C 1 ATOM 1577 O O . VAL A 1 204 ? 130.091 9.790 36.655 1.00 34.86 ? 204 VAL A O 1 ATOM 1578 C CB . VAL A 1 204 ? 129.318 13.088 37.171 1.00 34.55 ? 204 VAL A CB 1 ATOM 1579 C CG1 . VAL A 1 204 ? 130.754 12.939 37.662 1.00 32.59 ? 204 VAL A CG1 1 ATOM 1580 C CG2 . VAL A 1 204 ? 129.194 14.346 36.293 1.00 33.01 ? 204 VAL A CG2 1 ATOM 1581 N N . SER A 1 205 ? 128.561 10.105 38.235 1.00 34.22 ? 205 SER A N 1 ATOM 1582 C CA . SER A 1 205 ? 128.930 8.852 38.911 1.00 35.33 ? 205 SER A CA 1 ATOM 1583 C C . SER A 1 205 ? 128.790 7.566 38.042 1.00 35.54 ? 205 SER A C 1 ATOM 1584 O O . SER A 1 205 ? 129.565 6.632 38.205 1.00 37.21 ? 205 SER A O 1 ATOM 1585 C CB . SER A 1 205 ? 128.224 8.705 40.257 1.00 33.89 ? 205 SER A CB 1 ATOM 1586 O OG . SER A 1 205 ? 126.833 8.609 40.081 1.00 35.11 ? 205 SER A OG 1 ATOM 1587 N N . LEU A 1 206 ? 127.827 7.532 37.138 1.00 35.72 ? 206 LEU A N 1 ATOM 1588 C CA . LEU A 1 206 ? 127.644 6.417 36.178 1.00 35.87 ? 206 LEU A CA 1 ATOM 1589 C C . LEU A 1 206 ? 128.704 6.374 35.073 1.00 35.55 ? 206 LEU A C 1 ATOM 1590 O O . LEU A 1 206 ? 128.995 5.316 34.515 1.00 34.32 ? 206 LEU A O 1 ATOM 1591 C CB . LEU A 1 206 ? 126.228 6.487 35.540 1.00 35.01 ? 206 LEU A CB 1 ATOM 1592 C CG . LEU A 1 206 ? 125.098 6.206 36.545 1.00 35.58 ? 206 LEU A CG 1 ATOM 1593 C CD1 . LEU A 1 206 ? 123.677 6.561 35.994 1.00 34.24 ? 206 LEU A CD1 1 ATOM 1594 C CD2 . LEU A 1 206 ? 125.146 4.763 37.178 1.00 31.60 ? 206 LEU A CD2 1 ATOM 1595 N N . HIS A 1 207 ? 129.248 7.531 34.726 1.00 35.98 ? 207 HIS A N 1 ATOM 1596 C CA . HIS A 1 207 ? 130.388 7.571 33.801 1.00 37.08 ? 207 HIS A CA 1 ATOM 1597 C C . HIS A 1 207 ? 131.664 6.995 34.457 1.00 38.41 ? 207 HIS A C 1 ATOM 1598 O O . HIS A 1 207 ? 132.503 6.437 33.774 1.00 39.94 ? 207 HIS A O 1 ATOM 1599 C CB . HIS A 1 207 ? 130.614 8.986 33.318 1.00 37.47 ? 207 HIS A CB 1 ATOM 1600 C CG . HIS A 1 207 ? 129.602 9.443 32.295 1.00 39.20 ? 207 HIS A CG 1 ATOM 1601 N ND1 . HIS A 1 207 ? 129.659 9.072 30.963 1.00 35.43 ? 207 HIS A ND1 1 ATOM 1602 C CD2 . HIS A 1 207 ? 128.507 10.237 32.417 1.00 36.80 ? 207 HIS A CD2 1 ATOM 1603 C CE1 . HIS A 1 207 ? 128.650 9.624 30.309 1.00 37.94 ? 207 HIS A CE1 1 ATOM 1604 N NE2 . HIS A 1 207 ? 127.949 10.354 31.163 1.00 37.62 ? 207 HIS A NE2 1 ATOM 1605 N N . LEU A 1 208 ? 131.768 7.099 35.777 1.00 38.15 ? 208 LEU A N 1 ATOM 1606 C CA . LEU A 1 208 ? 132.843 6.480 36.561 1.00 39.26 ? 208 LEU A CA 1 ATOM 1607 C C . LEU A 1 208 ? 132.742 4.955 36.523 1.00 39.39 ? 208 LEU A C 1 ATOM 1608 O O . LEU A 1 208 ? 133.733 4.251 36.658 1.00 39.06 ? 208 LEU A O 1 ATOM 1609 C CB . LEU A 1 208 ? 132.804 6.967 38.022 1.00 37.75 ? 208 LEU A CB 1 ATOM 1610 C CG . LEU A 1 208 ? 133.388 8.357 38.262 1.00 37.01 ? 208 LEU A CG 1 ATOM 1611 C CD1 . LEU A 1 208 ? 132.999 8.825 39.651 1.00 33.14 ? 208 LEU A CD1 1 ATOM 1612 C CD2 . LEU A 1 208 ? 134.939 8.426 38.069 1.00 31.31 ? 208 LEU A CD2 1 ATOM 1613 N N . LEU A 1 209 ? 131.525 4.461 36.309 1.00 40.72 ? 209 LEU A N 1 ATOM 1614 C CA . LEU A 1 209 ? 131.278 3.031 36.196 1.00 41.03 ? 209 LEU A CA 1 ATOM 1615 C C . LEU A 1 209 ? 131.234 2.488 34.778 1.00 41.76 ? 209 LEU A C 1 ATOM 1616 O O . LEU A 1 209 ? 131.348 1.295 34.597 1.00 44.25 ? 209 LEU A O 1 ATOM 1617 C CB . LEU A 1 209 ? 129.938 2.677 36.799 1.00 40.71 ? 209 LEU A CB 1 ATOM 1618 C CG . LEU A 1 209 ? 129.477 3.003 38.209 1.00 40.72 ? 209 LEU A CG 1 ATOM 1619 C CD1 . LEU A 1 209 ? 128.118 2.391 38.314 1.00 38.68 ? 209 LEU A CD1 1 ATOM 1620 C CD2 . LEU A 1 209 ? 130.362 2.408 39.229 1.00 39.43 ? 209 LEU A CD2 1 ATOM 1621 N N . SER A 1 210 ? 130.986 3.320 33.785 1.00 42.26 ? 210 SER A N 1 ATOM 1622 C CA . SER A 1 210 ? 130.827 2.803 32.458 1.00 43.06 ? 210 SER A CA 1 ATOM 1623 C C . SER A 1 210 ? 132.185 2.625 31.858 1.00 43.96 ? 210 SER A C 1 ATOM 1624 O O . SER A 1 210 ? 132.930 3.580 31.744 1.00 43.56 ? 210 SER A O 1 ATOM 1625 C CB . SER A 1 210 ? 129.966 3.708 31.558 1.00 42.81 ? 210 SER A CB 1 ATOM 1626 O OG . SER A 1 210 ? 129.633 2.998 30.371 1.00 42.51 ? 210 SER A OG 1 ATOM 1627 N N . PRO A 1 211 ? 132.493 1.401 31.410 1.00 45.40 ? 211 PRO A N 1 ATOM 1628 C CA . PRO A 1 211 ? 133.805 1.148 30.830 1.00 45.65 ? 211 PRO A CA 1 ATOM 1629 C C . PRO A 1 211 ? 133.980 2.001 29.554 1.00 46.25 ? 211 PRO A C 1 ATOM 1630 O O . PRO A 1 211 ? 135.094 2.476 29.278 1.00 47.62 ? 211 PRO A O 1 ATOM 1631 C CB . PRO A 1 211 ? 133.797 -0.364 30.558 1.00 46.13 ? 211 PRO A CB 1 ATOM 1632 C CG . PRO A 1 211 ? 132.633 -0.914 31.324 1.00 45.87 ? 211 PRO A CG 1 ATOM 1633 C CD . PRO A 1 211 ? 131.616 0.209 31.388 1.00 45.17 ? 211 PRO A CD 1 ATOM 1634 N N . GLY A 1 212 ? 132.888 2.267 28.842 1.00 45.46 ? 212 GLY A N 1 ATOM 1635 C CA . GLY A 1 212 ? 132.945 3.044 27.602 1.00 44.82 ? 212 GLY A CA 1 ATOM 1636 C C . GLY A 1 212 ? 133.234 4.521 27.855 1.00 44.21 ? 212 GLY A C 1 ATOM 1637 O O . GLY A 1 212 ? 133.626 5.243 26.955 1.00 44.64 ? 212 GLY A O 1 ATOM 1638 N N . SER A 1 213 ? 133.057 4.978 29.082 1.00 42.84 ? 213 SER A N 1 ATOM 1639 C CA . SER A 1 213 ? 133.441 6.354 29.418 1.00 41.64 ? 213 SER A CA 1 ATOM 1640 C C . SER A 1 213 ? 134.821 6.525 30.035 1.00 41.16 ? 213 SER A C 1 ATOM 1641 O O . SER A 1 213 ? 135.291 7.649 30.172 1.00 41.48 ? 213 SER A O 1 ATOM 1642 C CB . SER A 1 213 ? 132.374 7.004 30.284 1.00 41.77 ? 213 SER A CB 1 ATOM 1643 O OG . SER A 1 213 ? 131.130 7.020 29.553 1.00 43.29 ? 213 SER A OG 1 ATOM 1644 N N A HIS A 1 214 ? 135.468 5.409 30.395 0.50 41.46 ? 214 HIS A N 1 ATOM 1645 N N B HIS A 1 214 ? 135.484 5.439 30.389 0.50 41.07 ? 214 HIS A N 1 ATOM 1646 C CA A HIS A 1 214 ? 136.774 5.401 31.127 0.50 41.79 ? 214 HIS A CA 1 ATOM 1647 C CA B HIS A 1 214 ? 136.711 5.579 31.185 0.50 41.06 ? 214 HIS A CA 1 ATOM 1648 C C A HIS A 1 214 ? 137.780 6.395 30.543 0.50 42.09 ? 214 HIS A C 1 ATOM 1649 C C B HIS A 1 214 ? 137.824 6.414 30.546 0.50 41.65 ? 214 HIS A C 1 ATOM 1650 O O A HIS A 1 214 ? 138.346 7.200 31.273 0.50 42.18 ? 214 HIS A O 1 ATOM 1651 O O B HIS A 1 214 ? 138.512 7.148 31.244 0.50 41.79 ? 214 HIS A O 1 ATOM 1652 C CB A HIS A 1 214 ? 137.386 3.968 31.210 0.50 41.47 ? 214 HIS A CB 1 ATOM 1653 C CB B HIS A 1 214 ? 137.206 4.220 31.705 0.50 40.29 ? 214 HIS A CB 1 ATOM 1654 C CG A HIS A 1 214 ? 138.594 3.845 32.104 0.50 41.26 ? 214 HIS A CG 1 ATOM 1655 C CG B HIS A 1 214 ? 136.326 3.637 32.767 0.50 38.66 ? 214 HIS A CG 1 ATOM 1656 N ND1 A HIS A 1 214 ? 138.565 3.176 33.313 0.50 41.98 ? 214 HIS A ND1 1 ATOM 1657 N ND1 B HIS A 1 214 ? 135.278 4.340 33.335 0.50 37.00 ? 214 HIS A ND1 1 ATOM 1658 C CD2 A HIS A 1 214 ? 139.874 4.267 31.947 0.50 40.62 ? 214 HIS A CD2 1 ATOM 1659 C CD2 B HIS A 1 214 ? 136.345 2.424 33.376 0.50 38.15 ? 214 HIS A CD2 1 ATOM 1660 C CE1 A HIS A 1 214 ? 139.764 3.211 33.869 0.50 39.20 ? 214 HIS A CE1 1 ATOM 1661 C CE1 B HIS A 1 214 ? 134.693 3.580 34.246 0.50 36.42 ? 214 HIS A CE1 1 ATOM 1662 N NE2 A HIS A 1 214 ? 140.576 3.871 33.062 0.50 40.21 ? 214 HIS A NE2 1 ATOM 1663 N NE2 B HIS A 1 214 ? 135.328 2.416 34.298 0.50 35.58 ? 214 HIS A NE2 1 ATOM 1664 N N . SER A 1 215 ? 137.961 6.353 29.222 1.00 42.86 ? 215 SER A N 1 ATOM 1665 C CA . SER A 1 215 ? 139.042 7.076 28.550 1.00 44.26 ? 215 SER A CA 1 ATOM 1666 C C . SER A 1 215 ? 138.587 8.361 27.927 1.00 44.19 ? 215 SER A C 1 ATOM 1667 O O . SER A 1 215 ? 139.348 8.951 27.127 1.00 44.83 ? 215 SER A O 1 ATOM 1668 C CB . SER A 1 215 ? 139.623 6.186 27.433 1.00 45.69 ? 215 SER A CB 1 ATOM 1669 O OG . SER A 1 215 ? 138.568 5.914 26.516 1.00 49.48 ? 215 SER A OG 1 ATOM 1670 N N . LEU A 1 216 ? 137.348 8.785 28.258 1.00 43.25 ? 216 LEU A N 1 ATOM 1671 C CA . LEU A 1 216 ? 136.810 10.065 27.772 1.00 41.08 ? 216 LEU A CA 1 ATOM 1672 C C . LEU A 1 216 ? 136.908 11.205 28.781 1.00 40.89 ? 216 LEU A C 1 ATOM 1673 O O . LEU A 1 216 ? 136.470 12.330 28.490 1.00 40.66 ? 216 LEU A O 1 ATOM 1674 C CB . LEU A 1 216 ? 135.388 9.919 27.280 1.00 39.73 ? 216 LEU A CB 1 ATOM 1675 C CG . LEU A 1 216 ? 135.067 8.762 26.373 1.00 39.58 ? 216 LEU A CG 1 ATOM 1676 C CD1 . LEU A 1 216 ? 133.567 8.796 25.987 1.00 34.55 ? 216 LEU A CD1 1 ATOM 1677 C CD2 . LEU A 1 216 ? 135.996 8.731 25.120 1.00 42.53 ? 216 LEU A CD2 1 ATOM 1678 N N . PHE A 1 217 ? 137.431 10.908 29.985 1.00 40.37 ? 217 PHE A N 1 ATOM 1679 C CA . PHE A 1 217 ? 137.640 11.965 31.012 1.00 38.48 ? 217 PHE A CA 1 ATOM 1680 C C . PHE A 1 217 ? 138.703 11.628 32.050 1.00 38.08 ? 217 PHE A C 1 ATOM 1681 O O . PHE A 1 217 ? 139.116 10.485 32.105 1.00 37.28 ? 217 PHE A O 1 ATOM 1682 C CB . PHE A 1 217 ? 136.306 12.352 31.692 1.00 38.51 ? 217 PHE A CB 1 ATOM 1683 C CG . PHE A 1 217 ? 135.751 11.327 32.669 1.00 34.93 ? 217 PHE A CG 1 ATOM 1684 C CD1 . PHE A 1 217 ? 135.142 10.162 32.218 1.00 34.04 ? 217 PHE A CD1 1 ATOM 1685 C CD2 . PHE A 1 217 ? 135.773 11.579 34.046 1.00 33.46 ? 217 PHE A CD2 1 ATOM 1686 C CE1 . PHE A 1 217 ? 134.595 9.242 33.106 1.00 31.58 ? 217 PHE A CE1 1 ATOM 1687 C CE2 . PHE A 1 217 ? 135.256 10.647 34.945 1.00 32.35 ? 217 PHE A CE2 1 ATOM 1688 C CZ . PHE A 1 217 ? 134.661 9.485 34.459 1.00 34.26 ? 217 PHE A CZ 1 ATOM 1689 N N . THR A 1 218 ? 139.117 12.609 32.868 1.00 37.74 ? 218 THR A N 1 ATOM 1690 C CA . THR A 1 218 ? 140.173 12.429 33.878 1.00 37.76 ? 218 THR A CA 1 ATOM 1691 C C . THR A 1 218 ? 139.640 12.288 35.332 1.00 38.20 ? 218 THR A C 1 ATOM 1692 O O . THR A 1 218 ? 139.989 11.336 36.058 1.00 37.08 ? 218 THR A O 1 ATOM 1693 C CB . THR A 1 218 ? 141.105 13.653 33.857 1.00 39.46 ? 218 THR A CB 1 ATOM 1694 O OG1 . THR A 1 218 ? 141.510 13.965 32.508 1.00 38.93 ? 218 THR A OG1 1 ATOM 1695 C CG2 . THR A 1 218 ? 142.422 13.379 34.621 1.00 37.46 ? 218 THR A CG2 1 ATOM 1696 N N . ARG A 1 219 ? 138.826 13.272 35.740 1.00 36.76 ? 219 ARG A N 1 ATOM 1697 C CA . ARG A 1 219 ? 138.389 13.463 37.114 1.00 35.91 ? 219 ARG A CA 1 ATOM 1698 C C . ARG A 1 219 ? 136.879 13.762 37.158 1.00 34.82 ? 219 ARG A C 1 ATOM 1699 O O . ARG A 1 219 ? 136.270 14.018 36.123 1.00 33.55 ? 219 ARG A O 1 ATOM 1700 C CB . ARG A 1 219 ? 139.178 14.635 37.693 1.00 36.56 ? 219 ARG A CB 1 ATOM 1701 C CG . ARG A 1 219 ? 140.343 14.185 38.482 1.00 40.90 ? 219 ARG A CG 1 ATOM 1702 C CD . ARG A 1 219 ? 141.124 15.281 39.233 1.00 39.52 ? 219 ARG A CD 1 ATOM 1703 N NE . ARG A 1 219 ? 141.859 16.084 38.297 1.00 42.64 ? 219 ARG A NE 1 ATOM 1704 C CZ . ARG A 1 219 ? 143.015 15.780 37.780 1.00 42.40 ? 219 ARG A CZ 1 ATOM 1705 N NH1 . ARG A 1 219 ? 143.537 16.600 36.903 1.00 41.41 ? 219 ARG A NH1 1 ATOM 1706 N NH2 . ARG A 1 219 ? 143.653 14.680 38.124 1.00 42.13 ? 219 ARG A NH2 1 ATOM 1707 N N . ALA A 1 220 ? 136.274 13.717 38.348 1.00 34.28 ? 220 ALA A N 1 ATOM 1708 C CA . ALA A 1 220 ? 134.810 13.943 38.484 1.00 32.75 ? 220 ALA A CA 1 ATOM 1709 C C . ALA A 1 220 ? 134.457 14.771 39.684 1.00 32.96 ? 220 ALA A C 1 ATOM 1710 O O . ALA A 1 220 ? 135.045 14.612 40.783 1.00 32.49 ? 220 ALA A O 1 ATOM 1711 C CB . ALA A 1 220 ? 134.041 12.604 38.518 1.00 31.25 ? 220 ALA A CB 1 ATOM 1712 N N . ILE A 1 221 ? 133.461 15.628 39.485 1.00 32.91 ? 221 ILE A N 1 ATOM 1713 C CA . ILE A 1 221 ? 132.830 16.420 40.568 1.00 33.37 ? 221 ILE A CA 1 ATOM 1714 C C . ILE A 1 221 ? 131.333 16.084 40.637 1.00 34.40 ? 221 ILE A C 1 ATOM 1715 O O . ILE A 1 221 ? 130.630 16.153 39.626 1.00 34.21 ? 221 ILE A O 1 ATOM 1716 C CB . ILE A 1 221 ? 133.013 17.944 40.324 1.00 32.58 ? 221 ILE A CB 1 ATOM 1717 C CG1 . ILE A 1 221 ? 134.490 18.295 40.218 1.00 31.73 ? 221 ILE A CG1 1 ATOM 1718 C CG2 . ILE A 1 221 ? 132.331 18.830 41.448 1.00 33.04 ? 221 ILE A CG2 1 ATOM 1719 C CD1 . ILE A 1 221 ? 134.755 19.765 40.072 1.00 30.41 ? 221 ILE A CD1 1 ATOM 1720 N N . LEU A 1 222 ? 130.864 15.715 41.828 1.00 35.34 ? 222 LEU A N 1 ATOM 1721 C CA . LEU A 1 222 ? 129.470 15.347 42.024 1.00 36.35 ? 222 LEU A CA 1 ATOM 1722 C C . LEU A 1 222 ? 128.757 16.265 43.035 1.00 36.28 ? 222 LEU A C 1 ATOM 1723 O O . LEU A 1 222 ? 128.933 16.146 44.258 1.00 34.51 ? 222 LEU A O 1 ATOM 1724 C CB . LEU A 1 222 ? 129.320 13.868 42.449 1.00 36.62 ? 222 LEU A CB 1 ATOM 1725 C CG . LEU A 1 222 ? 129.876 12.710 41.623 1.00 36.85 ? 222 LEU A CG 1 ATOM 1726 C CD1 . LEU A 1 222 ? 131.388 12.754 41.742 1.00 37.38 ? 222 LEU A CD1 1 ATOM 1727 C CD2 . LEU A 1 222 ? 129.327 11.400 42.207 1.00 36.67 ? 222 LEU A CD2 1 ATOM 1728 N N . GLN A 1 223 ? 127.976 17.197 42.485 1.00 35.30 ? 223 GLN A N 1 ATOM 1729 C CA . GLN A 1 223 ? 127.163 18.099 43.294 1.00 34.63 ? 223 GLN A CA 1 ATOM 1730 C C . GLN A 1 223 ? 125.727 17.578 43.607 1.00 34.13 ? 223 GLN A C 1 ATOM 1731 O O . GLN A 1 223 ? 124.891 17.446 42.708 1.00 34.28 ? 223 GLN A O 1 ATOM 1732 C CB . GLN A 1 223 ? 127.152 19.483 42.648 1.00 33.95 ? 223 GLN A CB 1 ATOM 1733 C CG . GLN A 1 223 ? 128.583 20.047 42.399 1.00 34.32 ? 223 GLN A CG 1 ATOM 1734 C CD . GLN A 1 223 ? 128.609 21.329 41.532 1.00 35.15 ? 223 GLN A CD 1 ATOM 1735 O OE1 . GLN A 1 223 ? 129.599 21.609 40.893 1.00 35.79 ? 223 GLN A OE1 1 ATOM 1736 N NE2 . GLN A 1 223 ? 127.530 22.108 41.553 1.00 37.69 ? 223 GLN A NE2 1 ATOM 1737 N N . SER A 1 224 ? 125.455 17.264 44.877 1.00 33.79 ? 224 SER A N 1 ATOM 1738 C CA . SER A 1 224 ? 124.091 16.853 45.304 1.00 34.75 ? 224 SER A CA 1 ATOM 1739 C C . SER A 1 224 ? 123.522 15.718 44.483 1.00 34.37 ? 224 SER A C 1 ATOM 1740 O O . SER A 1 224 ? 122.382 15.854 44.013 1.00 34.99 ? 224 SER A O 1 ATOM 1741 C CB . SER A 1 224 ? 123.087 18.022 45.163 1.00 34.59 ? 224 SER A CB 1 ATOM 1742 O OG . SER A 1 224 ? 123.466 19.135 45.975 1.00 37.44 ? 224 SER A OG 1 ATOM 1743 N N . GLY A 1 225 ? 124.295 14.662 44.219 1.00 33.19 ? 225 GLY A N 1 ATOM 1744 C CA . GLY A 1 225 ? 123.774 13.528 43.415 1.00 33.08 ? 225 GLY A CA 1 ATOM 1745 C C . GLY A 1 225 ? 124.838 12.442 43.268 1.00 34.34 ? 225 GLY A C 1 ATOM 1746 O O . GLY A 1 225 ? 126.042 12.747 43.298 1.00 33.57 ? 225 GLY A O 1 ATOM 1747 N N . SER A 1 226 ? 124.394 11.183 43.163 1.00 34.87 ? 226 SER A N 1 ATOM 1748 C CA . SER A 1 226 ? 125.252 9.994 42.951 1.00 35.14 ? 226 SER A CA 1 ATOM 1749 C C . SER A 1 226 ? 124.293 8.868 42.546 1.00 35.98 ? 226 SER A C 1 ATOM 1750 O O . SER A 1 226 ? 123.109 8.907 42.881 1.00 34.97 ? 226 SER A O 1 ATOM 1751 C CB . SER A 1 226 ? 126.046 9.649 44.209 1.00 34.44 ? 226 SER A CB 1 ATOM 1752 O OG . SER A 1 226 ? 125.153 9.555 45.334 1.00 35.79 ? 226 SER A OG 1 ATOM 1753 N N A PHE A 1 227 ? 124.826 7.878 41.829 0.50 36.29 ? 227 PHE A N 1 ATOM 1754 N N B PHE A 1 227 ? 124.762 7.884 41.784 0.50 36.28 ? 227 PHE A N 1 ATOM 1755 C CA A PHE A 1 227 ? 124.014 6.805 41.250 0.50 36.47 ? 227 PHE A CA 1 ATOM 1756 C CA B PHE A 1 227 ? 123.838 6.864 41.271 0.50 36.38 ? 227 PHE A CA 1 ATOM 1757 C C A PHE A 1 227 ? 123.374 5.835 42.252 0.50 36.66 ? 227 PHE A C 1 ATOM 1758 C C B PHE A 1 227 ? 123.083 6.119 42.371 0.50 36.59 ? 227 PHE A C 1 ATOM 1759 O O A PHE A 1 227 ? 122.614 4.965 41.834 0.50 36.72 ? 227 PHE A O 1 ATOM 1760 O O B PHE A 1 227 ? 121.966 5.655 42.141 0.50 36.28 ? 227 PHE A O 1 ATOM 1761 C CB A PHE A 1 227 ? 124.824 6.008 40.194 0.50 36.94 ? 227 PHE A CB 1 ATOM 1762 C CB B PHE A 1 227 ? 124.576 5.823 40.413 0.50 37.15 ? 227 PHE A CB 1 ATOM 1763 C CG A PHE A 1 227 ? 126.000 5.221 40.768 0.50 35.62 ? 227 PHE A CG 1 ATOM 1764 C CG B PHE A 1 227 ? 125.282 4.772 41.227 0.50 35.86 ? 227 PHE A CG 1 ATOM 1765 C CD1 A PHE A 1 227 ? 127.297 5.551 40.426 0.50 34.64 ? 227 PHE A CD1 1 ATOM 1766 C CD1 B PHE A 1 227 ? 126.628 4.900 41.525 0.50 33.98 ? 227 PHE A CD1 1 ATOM 1767 C CD2 A PHE A 1 227 ? 125.799 4.156 41.627 0.50 33.59 ? 227 PHE A CD2 1 ATOM 1768 C CD2 B PHE A 1 227 ? 124.582 3.684 41.731 0.50 36.88 ? 227 PHE A CD2 1 ATOM 1769 C CE1 A PHE A 1 227 ? 128.365 4.870 40.943 0.50 33.55 ? 227 PHE A CE1 1 ATOM 1770 C CE1 B PHE A 1 227 ? 127.271 3.963 42.288 0.50 34.43 ? 227 PHE A CE1 1 ATOM 1771 C CE2 A PHE A 1 227 ? 126.857 3.456 42.143 0.50 33.55 ? 227 PHE A CE2 1 ATOM 1772 C CE2 B PHE A 1 227 ? 125.218 2.729 42.511 0.50 35.03 ? 227 PHE A CE2 1 ATOM 1773 C CZ A PHE A 1 227 ? 128.154 3.812 41.799 0.50 34.28 ? 227 PHE A CZ 1 ATOM 1774 C CZ B PHE A 1 227 ? 126.574 2.864 42.774 0.50 33.65 ? 227 PHE A CZ 1 ATOM 1775 N N . ASN A 1 228 ? 123.706 5.965 43.544 1.00 36.82 ? 228 ASN A N 1 ATOM 1776 C CA . ASN A 1 228 ? 123.112 5.153 44.649 1.00 36.43 ? 228 ASN A CA 1 ATOM 1777 C C . ASN A 1 228 ? 121.994 5.846 45.400 1.00 36.13 ? 228 ASN A C 1 ATOM 1778 O O . ASN A 1 228 ? 121.373 5.252 46.297 1.00 37.10 ? 228 ASN A O 1 ATOM 1779 C CB . ASN A 1 228 ? 124.193 4.690 45.644 1.00 35.99 ? 228 ASN A CB 1 ATOM 1780 C CG . ASN A 1 228 ? 124.982 5.859 46.234 1.00 38.69 ? 228 ASN A CG 1 ATOM 1781 O OD1 . ASN A 1 228 ? 125.266 6.855 45.535 1.00 41.06 ? 228 ASN A OD1 1 ATOM 1782 N ND2 . ASN A 1 228 ? 125.309 5.775 47.514 1.00 35.21 ? 228 ASN A ND2 1 ATOM 1783 N N . ALA A 1 229 ? 121.730 7.108 45.087 1.00 35.89 ? 229 ALA A N 1 ATOM 1784 C CA . ALA A 1 229 ? 120.485 7.781 45.561 1.00 36.83 ? 229 ALA A CA 1 ATOM 1785 C C . ALA A 1 229 ? 119.226 6.993 45.148 1.00 35.87 ? 229 ALA A C 1 ATOM 1786 O O . ALA A 1 229 ? 119.182 6.410 44.080 1.00 35.91 ? 229 ALA A O 1 ATOM 1787 C CB . ALA A 1 229 ? 120.405 9.234 45.027 1.00 36.46 ? 229 ALA A CB 1 ATOM 1788 N N . PRO A 1 230 ? 118.178 6.978 45.955 1.00 36.60 ? 230 PRO A N 1 ATOM 1789 C CA . PRO A 1 230 ? 117.012 6.106 45.624 1.00 36.70 ? 230 PRO A CA 1 ATOM 1790 C C . PRO A 1 230 ? 116.286 6.411 44.287 1.00 37.65 ? 230 PRO A C 1 ATOM 1791 O O . PRO A 1 230 ? 115.639 5.509 43.692 1.00 37.32 ? 230 PRO A O 1 ATOM 1792 C CB . PRO A 1 230 ? 116.074 6.283 46.794 1.00 37.64 ? 230 PRO A CB 1 ATOM 1793 C CG . PRO A 1 230 ? 116.661 7.445 47.688 1.00 38.32 ? 230 PRO A CG 1 ATOM 1794 C CD . PRO A 1 230 ? 118.013 7.767 47.193 1.00 35.88 ? 230 PRO A CD 1 ATOM 1795 N N . TRP A 1 231 ? 116.435 7.630 43.776 1.00 37.05 ? 231 TRP A N 1 ATOM 1796 C CA . TRP A 1 231 ? 115.738 8.035 42.548 1.00 36.27 ? 231 TRP A CA 1 ATOM 1797 C C . TRP A 1 231 ? 116.534 7.833 41.291 1.00 37.44 ? 231 TRP A C 1 ATOM 1798 O O . TRP A 1 231 ? 116.073 8.165 40.223 1.00 38.65 ? 231 TRP A O 1 ATOM 1799 C CB . TRP A 1 231 ? 115.400 9.519 42.653 1.00 36.28 ? 231 TRP A CB 1 ATOM 1800 C CG . TRP A 1 231 ? 116.562 10.381 43.149 1.00 34.29 ? 231 TRP A CG 1 ATOM 1801 C CD1 . TRP A 1 231 ? 116.778 10.793 44.428 1.00 34.34 ? 231 TRP A CD1 1 ATOM 1802 C CD2 . TRP A 1 231 ? 117.674 10.896 42.374 1.00 32.59 ? 231 TRP A CD2 1 ATOM 1803 N NE1 . TRP A 1 231 ? 117.930 11.541 44.500 1.00 35.08 ? 231 TRP A NE1 1 ATOM 1804 C CE2 . TRP A 1 231 ? 118.493 11.627 43.248 1.00 33.60 ? 231 TRP A CE2 1 ATOM 1805 C CE3 . TRP A 1 231 ? 118.039 10.835 41.024 1.00 33.26 ? 231 TRP A CE3 1 ATOM 1806 C CZ2 . TRP A 1 231 ? 119.679 12.262 42.826 1.00 32.62 ? 231 TRP A CZ2 1 ATOM 1807 C CZ3 . TRP A 1 231 ? 119.213 11.504 40.602 1.00 30.20 ? 231 TRP A CZ3 1 ATOM 1808 C CH2 . TRP A 1 231 ? 120.001 12.196 41.501 1.00 30.04 ? 231 TRP A CH2 1 ATOM 1809 N N . ALA A 1 232 ? 117.766 7.345 41.402 1.00 38.36 ? 232 ALA A N 1 ATOM 1810 C CA . ALA A 1 232 ? 118.707 7.486 40.322 1.00 38.29 ? 232 ALA A CA 1 ATOM 1811 C C . ALA A 1 232 ? 118.725 6.367 39.297 1.00 39.37 ? 232 ALA A C 1 ATOM 1812 O O . ALA A 1 232 ? 119.152 6.560 38.165 1.00 39.41 ? 232 ALA A O 1 ATOM 1813 C CB . ALA A 1 232 ? 120.097 7.702 40.892 1.00 38.54 ? 232 ALA A CB 1 ATOM 1814 N N . VAL A 1 233 ? 118.347 5.170 39.703 1.00 39.87 ? 233 VAL A N 1 ATOM 1815 C CA . VAL A 1 233 ? 118.401 4.036 38.775 1.00 41.67 ? 233 VAL A CA 1 ATOM 1816 C C . VAL A 1 233 ? 117.028 3.340 38.686 1.00 43.88 ? 233 VAL A C 1 ATOM 1817 O O . VAL A 1 233 ? 116.447 2.977 39.706 1.00 42.82 ? 233 VAL A O 1 ATOM 1818 C CB . VAL A 1 233 ? 119.532 3.040 39.173 1.00 41.17 ? 233 VAL A CB 1 ATOM 1819 C CG1 . VAL A 1 233 ? 119.467 1.773 38.359 1.00 36.50 ? 233 VAL A CG1 1 ATOM 1820 C CG2 . VAL A 1 233 ? 120.969 3.736 39.090 1.00 39.76 ? 233 VAL A CG2 1 ATOM 1821 N N . THR A 1 234 ? 116.498 3.203 37.470 1.00 46.44 ? 234 THR A N 1 ATOM 1822 C CA . THR A 1 234 ? 115.193 2.533 37.287 1.00 49.05 ? 234 THR A CA 1 ATOM 1823 C C . THR A 1 234 ? 115.415 1.008 37.231 1.00 51.09 ? 234 THR A C 1 ATOM 1824 O O . THR A 1 234 ? 116.200 0.506 36.412 1.00 51.56 ? 234 THR A O 1 ATOM 1825 C CB . THR A 1 234 ? 114.445 3.035 35.997 1.00 49.05 ? 234 THR A CB 1 ATOM 1826 O OG1 . THR A 1 234 ? 114.321 4.472 36.012 1.00 47.14 ? 234 THR A OG1 1 ATOM 1827 C CG2 . THR A 1 234 ? 112.959 2.497 35.955 1.00 49.19 ? 234 THR A CG2 1 ATOM 1828 N N . SER A 1 235 ? 114.756 0.270 38.120 1.00 53.57 ? 235 SER A N 1 ATOM 1829 C CA . SER A 1 235 ? 114.826 -1.199 38.062 1.00 56.27 ? 235 SER A CA 1 ATOM 1830 C C . SER A 1 235 ? 114.270 -1.717 36.714 1.00 57.42 ? 235 SER A C 1 ATOM 1831 O O . SER A 1 235 ? 113.389 -1.101 36.096 1.00 57.25 ? 235 SER A O 1 ATOM 1832 C CB . SER A 1 235 ? 114.069 -1.822 39.232 1.00 55.81 ? 235 SER A CB 1 ATOM 1833 O OG . SER A 1 235 ? 112.708 -1.993 38.891 1.00 58.11 ? 235 SER A OG 1 ATOM 1834 N N . LEU A 1 236 ? 114.832 -2.817 36.242 1.00 59.40 ? 236 LEU A N 1 ATOM 1835 C CA . LEU A 1 236 ? 114.368 -3.478 35.016 1.00 61.42 ? 236 LEU A CA 1 ATOM 1836 C C . LEU A 1 236 ? 112.868 -3.867 35.080 1.00 61.90 ? 236 LEU A C 1 ATOM 1837 O O . LEU A 1 236 ? 112.172 -3.799 34.071 1.00 61.47 ? 236 LEU A O 1 ATOM 1838 C CB . LEU A 1 236 ? 115.285 -4.660 34.739 1.00 61.70 ? 236 LEU A CB 1 ATOM 1839 C CG . LEU A 1 236 ? 114.903 -5.911 33.971 1.00 64.63 ? 236 LEU A CG 1 ATOM 1840 C CD1 . LEU A 1 236 ? 116.104 -6.307 33.067 1.00 64.70 ? 236 LEU A CD1 1 ATOM 1841 C CD2 . LEU A 1 236 ? 114.477 -7.072 34.955 1.00 66.90 ? 236 LEU A CD2 1 ATOM 1842 N N . TYR A 1 237 ? 112.391 -4.228 36.276 1.00 63.08 ? 237 TYR A N 1 ATOM 1843 C CA . TYR A 1 237 ? 110.968 -4.474 36.550 1.00 64.16 ? 237 TYR A CA 1 ATOM 1844 C C . TYR A 1 237 ? 110.101 -3.204 36.419 1.00 63.53 ? 237 TYR A C 1 ATOM 1845 O O . TYR A 1 237 ? 109.088 -3.212 35.703 1.00 63.75 ? 237 TYR A O 1 ATOM 1846 C CB . TYR A 1 237 ? 110.764 -5.182 37.922 1.00 65.25 ? 237 TYR A CB 1 ATOM 1847 C CG . TYR A 1 237 ? 109.328 -5.668 38.179 1.00 69.70 ? 237 TYR A CG 1 ATOM 1848 C CD1 . TYR A 1 237 ? 108.296 -4.757 38.498 1.00 73.80 ? 237 TYR A CD1 1 ATOM 1849 C CD2 . TYR A 1 237 ? 108.991 -7.029 38.098 1.00 71.33 ? 237 TYR A CD2 1 ATOM 1850 C CE1 . TYR A 1 237 ? 106.967 -5.182 38.719 1.00 73.45 ? 237 TYR A CE1 1 ATOM 1851 C CE2 . TYR A 1 237 ? 107.665 -7.467 38.328 1.00 72.63 ? 237 TYR A CE2 1 ATOM 1852 C CZ . TYR A 1 237 ? 106.659 -6.535 38.644 1.00 74.35 ? 237 TYR A CZ 1 ATOM 1853 O OH . TYR A 1 237 ? 105.338 -6.942 38.876 1.00 74.67 ? 237 TYR A OH 1 ATOM 1854 N N . GLU A 1 238 ? 110.483 -2.122 37.097 1.00 62.49 ? 238 GLU A N 1 ATOM 1855 C CA . GLU A 1 238 ? 109.766 -0.853 36.955 1.00 61.19 ? 238 GLU A CA 1 ATOM 1856 C C . GLU A 1 238 ? 109.811 -0.330 35.499 1.00 60.01 ? 238 GLU A C 1 ATOM 1857 O O . GLU A 1 238 ? 108.809 0.150 34.980 1.00 59.65 ? 238 GLU A O 1 ATOM 1858 C CB . GLU A 1 238 ? 110.328 0.229 37.891 1.00 61.51 ? 238 GLU A CB 1 ATOM 1859 C CG . GLU A 1 238 ? 110.221 -0.003 39.397 1.00 63.40 ? 238 GLU A CG 1 ATOM 1860 C CD . GLU A 1 238 ? 111.157 0.922 40.200 1.00 66.21 ? 238 GLU A CD 1 ATOM 1861 O OE1 . GLU A 1 238 ? 112.342 1.131 39.817 1.00 66.06 ? 238 GLU A OE1 1 ATOM 1862 O OE2 . GLU A 1 238 ? 110.713 1.459 41.237 1.00 68.43 ? 238 GLU A OE2 1 ATOM 1863 N N . ALA A 1 239 ? 110.978 -0.386 34.867 1.00 58.27 ? 239 ALA A N 1 ATOM 1864 C CA . ALA A 1 239 ? 111.135 0.067 33.495 1.00 57.69 ? 239 ALA A CA 1 ATOM 1865 C C . ALA A 1 239 ? 110.140 -0.626 32.571 1.00 57.86 ? 239 ALA A C 1 ATOM 1866 O O . ALA A 1 239 ? 109.427 0.052 31.829 1.00 57.88 ? 239 ALA A O 1 ATOM 1867 C CB . ALA A 1 239 ? 112.560 -0.119 33.008 1.00 56.67 ? 239 ALA A CB 1 ATOM 1868 N N . ARG A 1 240 ? 110.072 -1.961 32.633 1.00 58.05 ? 240 ARG A N 1 ATOM 1869 C CA . ARG A 1 240 ? 109.115 -2.761 31.831 1.00 58.28 ? 240 ARG A CA 1 ATOM 1870 C C . ARG A 1 240 ? 107.688 -2.292 32.020 1.00 57.11 ? 240 ARG A C 1 ATOM 1871 O O . ARG A 1 240 ? 107.005 -1.997 31.062 1.00 56.76 ? 240 ARG A O 1 ATOM 1872 C CB . ARG A 1 240 ? 109.209 -4.258 32.188 1.00 59.20 ? 240 ARG A CB 1 ATOM 1873 C CG . ARG A 1 240 ? 107.921 -5.085 31.891 1.00 61.52 ? 240 ARG A CG 1 ATOM 1874 C CD . ARG A 1 240 ? 108.144 -6.620 31.958 1.00 67.22 ? 240 ARG A CD 1 ATOM 1875 N NE . ARG A 1 240 ? 107.283 -7.419 31.061 1.00 69.62 ? 240 ARG A NE 1 ATOM 1876 C CZ . ARG A 1 240 ? 107.384 -7.459 29.720 1.00 71.89 ? 240 ARG A CZ 1 ATOM 1877 N NH1 . ARG A 1 240 ? 108.287 -6.718 29.062 1.00 71.62 ? 240 ARG A NH1 1 ATOM 1878 N NH2 . ARG A 1 240 ? 106.549 -8.234 29.027 1.00 74.29 ? 240 ARG A NH2 1 ATOM 1879 N N . ASN A 1 241 ? 107.259 -2.202 33.270 1.00 57.08 ? 241 ASN A N 1 ATOM 1880 C CA . ASN A 1 241 ? 105.909 -1.780 33.601 1.00 57.34 ? 241 ASN A CA 1 ATOM 1881 C C . ASN A 1 241 ? 105.591 -0.414 33.039 1.00 56.71 ? 241 ASN A C 1 ATOM 1882 O O . ASN A 1 241 ? 104.439 -0.138 32.667 1.00 57.35 ? 241 ASN A O 1 ATOM 1883 C CB . ASN A 1 241 ? 105.704 -1.764 35.120 1.00 58.76 ? 241 ASN A CB 1 ATOM 1884 C CG . ASN A 1 241 ? 104.274 -2.141 35.533 1.00 62.07 ? 241 ASN A CG 1 ATOM 1885 O OD1 . ASN A 1 241 ? 103.838 -3.294 35.371 1.00 61.89 ? 241 ASN A OD1 1 ATOM 1886 N ND2 . ASN A 1 241 ? 103.552 -1.167 36.082 1.00 68.03 ? 241 ASN A ND2 1 ATOM 1887 N N . ARG A 1 242 ? 106.618 0.432 32.961 1.00 55.18 ? 242 ARG A N 1 ATOM 1888 C CA . ARG A 1 242 ? 106.455 1.816 32.590 1.00 53.62 ? 242 ARG A CA 1 ATOM 1889 C C . ARG A 1 242 ? 106.445 1.962 31.079 1.00 53.02 ? 242 ARG A C 1 ATOM 1890 O O . ARG A 1 242 ? 105.587 2.641 30.538 1.00 52.77 ? 242 ARG A O 1 ATOM 1891 C CB . ARG A 1 242 ? 107.520 2.691 33.265 1.00 53.00 ? 242 ARG A CB 1 ATOM 1892 C CG . ARG A 1 242 ? 107.394 2.758 34.769 1.00 52.87 ? 242 ARG A CG 1 ATOM 1893 C CD . ARG A 1 242 ? 108.604 3.423 35.464 1.00 54.55 ? 242 ARG A CD 1 ATOM 1894 N NE . ARG A 1 242 ? 108.533 3.387 36.926 1.00 52.87 ? 242 ARG A NE 1 ATOM 1895 C CZ . ARG A 1 242 ? 109.375 4.021 37.765 1.00 54.20 ? 242 ARG A CZ 1 ATOM 1896 N NH1 . ARG A 1 242 ? 110.387 4.758 37.316 1.00 51.35 ? 242 ARG A NH1 1 ATOM 1897 N NH2 . ARG A 1 242 ? 109.207 3.905 39.075 1.00 52.25 ? 242 ARG A NH2 1 ATOM 1898 N N . THR A 1 243 ? 107.389 1.326 30.401 1.00 52.90 ? 243 THR A N 1 ATOM 1899 C CA . THR A 1 243 ? 107.335 1.206 28.945 1.00 53.68 ? 243 THR A CA 1 ATOM 1900 C C . THR A 1 243 ? 105.940 0.704 28.468 1.00 54.55 ? 243 THR A C 1 ATOM 1901 O O . THR A 1 243 ? 105.396 1.261 27.516 1.00 53.94 ? 243 THR A O 1 ATOM 1902 C CB . THR A 1 243 ? 108.450 0.259 28.449 1.00 53.95 ? 243 THR A CB 1 ATOM 1903 O OG1 . THR A 1 243 ? 109.729 0.870 28.648 1.00 54.11 ? 243 THR A OG1 1 ATOM 1904 C CG2 . THR A 1 243 ? 108.397 0.041 26.936 1.00 53.13 ? 243 THR A CG2 1 ATOM 1905 N N . LEU A 1 244 ? 105.368 -0.315 29.137 1.00 55.12 ? 244 LEU A N 1 ATOM 1906 C CA . LEU A 1 244 ? 104.021 -0.833 28.777 1.00 55.76 ? 244 LEU A CA 1 ATOM 1907 C C . LEU A 1 244 ? 102.872 0.064 29.202 1.00 56.54 ? 244 LEU A C 1 ATOM 1908 O O . LEU A 1 244 ? 101.937 0.265 28.425 1.00 56.98 ? 244 LEU A O 1 ATOM 1909 C CB . LEU A 1 244 ? 103.749 -2.241 29.296 1.00 55.37 ? 244 LEU A CB 1 ATOM 1910 C CG . LEU A 1 244 ? 104.799 -3.299 29.035 1.00 55.07 ? 244 LEU A CG 1 ATOM 1911 C CD1 . LEU A 1 244 ? 104.489 -4.569 29.858 1.00 53.47 ? 244 LEU A CD1 1 ATOM 1912 C CD2 . LEU A 1 244 ? 104.967 -3.529 27.510 1.00 55.71 ? 244 LEU A CD2 1 ATOM 1913 N N . ASN A 1 245 ? 102.917 0.608 30.414 1.00 57.10 ? 245 ASN A N 1 ATOM 1914 C CA . ASN A 1 245 ? 101.943 1.647 30.756 1.00 57.53 ? 245 ASN A CA 1 ATOM 1915 C C . ASN A 1 245 ? 101.924 2.795 29.738 1.00 57.86 ? 245 ASN A C 1 ATOM 1916 O O . ASN A 1 245 ? 100.858 3.198 29.292 1.00 58.53 ? 245 ASN A O 1 ATOM 1917 C CB . ASN A 1 245 ? 102.138 2.167 32.179 1.00 57.80 ? 245 ASN A CB 1 ATOM 1918 C CG . ASN A 1 245 ? 101.785 1.133 33.234 1.00 58.44 ? 245 ASN A CG 1 ATOM 1919 O OD1 . ASN A 1 245 ? 101.431 -0.016 32.911 1.00 58.32 ? 245 ASN A OD1 1 ATOM 1920 N ND2 . ASN A 1 245 ? 101.887 1.528 34.510 1.00 57.22 ? 245 ASN A ND2 1 ATOM 1921 N N . LEU A 1 246 ? 103.089 3.307 29.346 1.00 57.75 ? 246 LEU A N 1 ATOM 1922 C CA . LEU A 1 246 ? 103.124 4.335 28.312 1.00 57.78 ? 246 LEU A CA 1 ATOM 1923 C C . LEU A 1 246 ? 102.492 3.842 27.003 1.00 58.15 ? 246 LEU A C 1 ATOM 1924 O O . LEU A 1 246 ? 101.807 4.610 26.345 1.00 57.49 ? 246 LEU A O 1 ATOM 1925 C CB . LEU A 1 246 ? 104.551 4.828 28.044 1.00 57.45 ? 246 LEU A CB 1 ATOM 1926 C CG . LEU A 1 246 ? 104.656 6.124 27.236 1.00 56.14 ? 246 LEU A CG 1 ATOM 1927 C CD1 . LEU A 1 246 ? 104.106 7.305 28.030 1.00 53.97 ? 246 LEU A CD1 1 ATOM 1928 C CD2 . LEU A 1 246 ? 106.080 6.350 26.788 1.00 53.34 ? 246 LEU A CD2 1 ATOM 1929 N N . ALA A 1 247 ? 102.760 2.582 26.633 1.00 58.80 ? 247 ALA A N 1 ATOM 1930 C CA . ALA A 1 247 ? 102.134 1.922 25.471 1.00 59.76 ? 247 ALA A CA 1 ATOM 1931 C C . ALA A 1 247 ? 100.599 1.903 25.581 1.00 60.76 ? 247 ALA A C 1 ATOM 1932 O O . ALA A 1 247 ? 99.911 2.404 24.682 1.00 61.09 ? 247 ALA A O 1 ATOM 1933 C CB . ALA A 1 247 ? 102.670 0.529 25.303 1.00 59.33 ? 247 ALA A CB 1 ATOM 1934 N N . LYS A 1 248 ? 100.074 1.366 26.689 1.00 61.42 ? 248 LYS A N 1 ATOM 1935 C CA . LYS A 1 248 ? 98.640 1.404 26.960 1.00 62.78 ? 248 LYS A CA 1 ATOM 1936 C C . LYS A 1 248 ? 98.126 2.795 26.583 1.00 62.61 ? 248 LYS A C 1 ATOM 1937 O O . LYS A 1 248 ? 97.280 2.940 25.687 1.00 63.05 ? 248 LYS A O 1 ATOM 1938 C CB . LYS A 1 248 ? 98.313 1.109 28.442 1.00 63.16 ? 248 LYS A CB 1 ATOM 1939 C CG . LYS A 1 248 ? 98.222 -0.390 28.856 1.00 67.03 ? 248 LYS A CG 1 ATOM 1940 C CD . LYS A 1 248 ? 98.590 -0.604 30.386 1.00 68.43 ? 248 LYS A CD 1 ATOM 1941 C CE . LYS A 1 248 ? 98.320 -2.024 30.935 1.00 69.11 ? 248 LYS A CE 1 ATOM 1942 N NZ . LYS A 1 248 ? 97.018 -2.138 31.693 1.00 67.95 ? 248 LYS A NZ 1 ATOM 1943 N N . LEU A 1 249 ? 98.679 3.807 27.255 1.00 61.97 ? 249 LEU A N 1 ATOM 1944 C CA . LEU A 1 249 ? 98.139 5.154 27.273 1.00 60.64 ? 249 LEU A CA 1 ATOM 1945 C C . LEU A 1 249 ? 98.158 5.865 25.930 1.00 60.77 ? 249 LEU A C 1 ATOM 1946 O O . LEU A 1 249 ? 97.457 6.854 25.760 1.00 60.66 ? 249 LEU A O 1 ATOM 1947 C CB . LEU A 1 249 ? 98.870 5.989 28.309 1.00 60.34 ? 249 LEU A CB 1 ATOM 1948 C CG . LEU A 1 249 ? 98.722 5.609 29.773 1.00 59.22 ? 249 LEU A CG 1 ATOM 1949 C CD1 . LEU A 1 249 ? 100.048 5.839 30.488 1.00 62.51 ? 249 LEU A CD1 1 ATOM 1950 C CD2 . LEU A 1 249 ? 97.621 6.396 30.460 1.00 60.41 ? 249 LEU A CD2 1 ATOM 1951 N N . THR A 1 250 ? 98.935 5.374 24.977 1.00 61.19 ? 250 THR A N 1 ATOM 1952 C CA . THR A 1 250 ? 99.013 6.018 23.657 1.00 62.44 ? 250 THR A CA 1 ATOM 1953 C C . THR A 1 250 ? 98.402 5.129 22.555 1.00 63.89 ? 250 THR A C 1 ATOM 1954 O O . THR A 1 250 ? 98.584 5.388 21.348 1.00 64.52 ? 250 THR A O 1 ATOM 1955 C CB . THR A 1 250 ? 100.479 6.356 23.287 1.00 61.96 ? 250 THR A CB 1 ATOM 1956 O OG1 . THR A 1 250 ? 101.255 5.156 23.326 1.00 60.48 ? 250 THR A OG1 1 ATOM 1957 C CG2 . THR A 1 250 ? 101.152 7.279 24.325 1.00 62.02 ? 250 THR A CG2 1 ATOM 1958 N N . GLY A 1 251 ? 97.698 4.078 22.975 1.00 64.85 ? 251 GLY A N 1 ATOM 1959 C CA . GLY A 1 251 ? 97.123 3.107 22.048 1.00 66.24 ? 251 GLY A CA 1 ATOM 1960 C C . GLY A 1 251 ? 98.173 2.278 21.348 1.00 67.41 ? 251 GLY A C 1 ATOM 1961 O O . GLY A 1 251 ? 97.945 1.779 20.245 1.00 67.35 ? 251 GLY A O 1 ATOM 1962 N N . CYS A 1 252 ? 99.319 2.105 22.006 1.00 68.10 ? 252 CYS A N 1 ATOM 1963 C CA . CYS A 1 252 ? 100.468 1.493 21.370 1.00 68.89 ? 252 CYS A CA 1 ATOM 1964 C C . CYS A 1 252 ? 100.716 0.078 21.873 1.00 69.69 ? 252 CYS A C 1 ATOM 1965 O O . CYS A 1 252 ? 101.717 -0.556 21.511 1.00 69.31 ? 252 CYS A O 1 ATOM 1966 C CB . CYS A 1 252 ? 101.711 2.398 21.512 1.00 68.74 ? 252 CYS A CB 1 ATOM 1967 S SG . CYS A 1 252 ? 101.769 3.817 20.353 1.00 68.76 ? 252 CYS A SG 1 ATOM 1968 N N . SER A 1 253 ? 99.796 -0.433 22.687 1.00 71.16 ? 253 SER A N 1 ATOM 1969 C CA . SER A 1 253 ? 99.913 -1.819 23.168 1.00 72.80 ? 253 SER A CA 1 ATOM 1970 C C . SER A 1 253 ? 99.948 -2.813 21.998 1.00 73.83 ? 253 SER A C 1 ATOM 1971 O O . SER A 1 253 ? 99.141 -2.749 21.076 1.00 73.83 ? 253 SER A O 1 ATOM 1972 C CB . SER A 1 253 ? 98.813 -2.175 24.177 1.00 72.81 ? 253 SER A CB 1 ATOM 1973 O OG . SER A 1 253 ? 98.890 -1.340 25.322 1.00 72.36 ? 253 SER A OG 1 ATOM 1974 N N . ARG A 1 254 ? 100.937 -3.696 22.033 1.00 75.23 ? 254 ARG A N 1 ATOM 1975 C CA . ARG A 1 254 ? 101.176 -4.666 20.971 1.00 76.34 ? 254 ARG A CA 1 ATOM 1976 C C . ARG A 1 254 ? 101.540 -6.006 21.626 1.00 77.35 ? 254 ARG A C 1 ATOM 1977 O O . ARG A 1 254 ? 100.958 -6.375 22.640 1.00 77.72 ? 254 ARG A O 1 ATOM 1978 C CB . ARG A 1 254 ? 102.291 -4.169 20.027 1.00 76.14 ? 254 ARG A CB 1 ATOM 1979 C CG . ARG A 1 254 ? 101.847 -3.547 18.689 1.00 75.11 ? 254 ARG A CG 1 ATOM 1980 C CD . ARG A 1 254 ? 100.470 -2.917 18.675 1.00 72.87 ? 254 ARG A CD 1 ATOM 1981 N NE . ARG A 1 254 ? 100.270 -1.944 17.599 1.00 68.85 ? 254 ARG A NE 1 ATOM 1982 C CZ . ARG A 1 254 ? 99.432 -0.919 17.687 1.00 64.97 ? 254 ARG A CZ 1 ATOM 1983 N NH1 . ARG A 1 254 ? 99.307 -0.076 16.676 1.00 64.58 ? 254 ARG A NH1 1 ATOM 1984 N NH2 . ARG A 1 254 ? 98.739 -0.718 18.798 1.00 60.64 ? 254 ARG A NH2 1 ATOM 1985 N N . GLU A 1 255 ? 102.482 -6.735 21.037 1.00 78.50 ? 255 GLU A N 1 ATOM 1986 C CA . GLU A 1 255 ? 102.972 -8.001 21.589 1.00 79.37 ? 255 GLU A CA 1 ATOM 1987 C C . GLU A 1 255 ? 104.357 -8.279 20.993 1.00 79.64 ? 255 GLU A C 1 ATOM 1988 O O . GLU A 1 255 ? 105.250 -8.775 21.690 1.00 79.99 ? 255 GLU A O 1 ATOM 1989 C CB . GLU A 1 255 ? 101.976 -9.170 21.383 1.00 79.35 ? 255 GLU A CB 1 ATOM 1990 C CG . GLU A 1 255 ? 101.574 -9.479 19.937 1.00 80.39 ? 255 GLU A CG 1 ATOM 1991 C CD . GLU A 1 255 ? 101.058 -8.269 19.155 0.50 80.28 ? 255 GLU A CD 1 ATOM 1992 O OE1 . GLU A 1 255 ? 100.075 -7.618 19.595 0.50 79.71 ? 255 GLU A OE1 1 ATOM 1993 O OE2 . GLU A 1 255 ? 101.636 -7.971 18.086 0.50 79.51 ? 255 GLU A OE2 1 ATOM 1994 N N . ASN A 1 256 ? 104.536 -7.952 19.711 1.00 79.37 ? 256 ASN A N 1 ATOM 1995 C CA . ASN A 1 256 ? 105.875 -7.830 19.154 1.00 79.42 ? 256 ASN A CA 1 ATOM 1996 C C . ASN A 1 256 ? 106.391 -6.507 19.749 1.00 79.05 ? 256 ASN A C 1 ATOM 1997 O O . ASN A 1 256 ? 105.957 -5.404 19.347 1.00 79.10 ? 256 ASN A O 1 ATOM 1998 C CB . ASN A 1 256 ? 105.851 -7.838 17.610 1.00 79.64 ? 256 ASN A CB 1 ATOM 1999 C CG . ASN A 1 256 ? 107.256 -7.901 16.974 1.00 81.34 ? 256 ASN A CG 1 ATOM 2000 O OD1 . ASN A 1 256 ? 108.089 -7.009 17.180 1.00 83.58 ? 256 ASN A OD1 1 ATOM 2001 N ND2 . ASN A 1 256 ? 107.504 -8.949 16.171 1.00 82.66 ? 256 ASN A ND2 1 ATOM 2002 N N . GLU A 1 257 ? 107.266 -6.623 20.751 1.00 77.70 ? 257 GLU A N 1 ATOM 2003 C CA . GLU A 1 257 ? 107.811 -5.440 21.423 1.00 76.46 ? 257 GLU A CA 1 ATOM 2004 C C . GLU A 1 257 ? 108.378 -4.406 20.434 1.00 75.69 ? 257 GLU A C 1 ATOM 2005 O O . GLU A 1 257 ? 108.393 -3.212 20.728 1.00 75.62 ? 257 GLU A O 1 ATOM 2006 C CB . GLU A 1 257 ? 108.839 -5.824 22.509 1.00 76.64 ? 257 GLU A CB 1 ATOM 2007 C CG . GLU A 1 257 ? 108.226 -6.468 23.761 1.00 75.98 ? 257 GLU A CG 1 ATOM 2008 C CD . GLU A 1 257 ? 109.246 -6.777 24.860 1.00 76.98 ? 257 GLU A CD 1 ATOM 2009 O OE1 . GLU A 1 257 ? 110.494 -6.720 24.597 1.00 75.65 ? 257 GLU A OE1 1 ATOM 2010 O OE2 . GLU A 1 257 ? 108.786 -7.081 25.997 1.00 75.88 ? 257 GLU A OE2 1 ATOM 2011 N N . THR A 1 258 ? 108.814 -4.863 19.260 1.00 74.71 ? 258 THR A N 1 ATOM 2012 C CA . THR A 1 258 ? 109.357 -3.971 18.230 1.00 73.70 ? 258 THR A CA 1 ATOM 2013 C C . THR A 1 258 ? 108.234 -3.228 17.482 1.00 72.60 ? 258 THR A C 1 ATOM 2014 O O . THR A 1 258 ? 108.465 -2.168 16.901 1.00 72.77 ? 258 THR A O 1 ATOM 2015 C CB . THR A 1 258 ? 110.269 -4.753 17.259 1.00 74.03 ? 258 THR A CB 1 ATOM 2016 O OG1 . THR A 1 258 ? 111.254 -5.487 18.003 1.00 74.31 ? 258 THR A OG1 1 ATOM 2017 C CG2 . THR A 1 258 ? 111.111 -3.798 16.379 1.00 74.95 ? 258 THR A CG2 1 ATOM 2018 N N . GLU A 1 259 ? 107.027 -3.799 17.505 1.00 70.96 ? 259 GLU A N 1 ATOM 2019 C CA . GLU A 1 259 ? 105.814 -3.093 17.083 1.00 69.22 ? 259 GLU A CA 1 ATOM 2020 C C . GLU A 1 259 ? 105.328 -2.039 18.100 1.00 67.40 ? 259 GLU A C 1 ATOM 2021 O O . GLU A 1 259 ? 104.657 -1.097 17.715 1.00 67.38 ? 259 GLU A O 1 ATOM 2022 C CB . GLU A 1 259 ? 104.679 -4.075 16.787 1.00 69.25 ? 259 GLU A CB 1 ATOM 2023 C CG . GLU A 1 259 ? 104.784 -4.814 15.454 1.00 70.70 ? 259 GLU A CG 1 ATOM 2024 C CD . GLU A 1 259 ? 103.730 -5.915 15.331 1.00 72.17 ? 259 GLU A CD 1 ATOM 2025 O OE1 . GLU A 1 259 ? 104.071 -7.031 14.874 1.00 72.38 ? 259 GLU A OE1 1 ATOM 2026 O OE2 . GLU A 1 259 ? 102.553 -5.669 15.708 1.00 73.12 ? 259 GLU A OE2 1 ATOM 2027 N N . ILE A 1 260 ? 105.636 -2.186 19.386 1.00 65.49 ? 260 ILE A N 1 ATOM 2028 C CA . ILE A 1 260 ? 105.285 -1.110 20.317 1.00 64.29 ? 260 ILE A CA 1 ATOM 2029 C C . ILE A 1 260 ? 106.123 0.135 20.030 1.00 63.16 ? 260 ILE A C 1 ATOM 2030 O O . ILE A 1 260 ? 105.594 1.212 19.782 1.00 62.75 ? 260 ILE A O 1 ATOM 2031 C CB . ILE A 1 260 ? 105.407 -1.526 21.792 1.00 64.56 ? 260 ILE A CB 1 ATOM 2032 C CG1 . ILE A 1 260 ? 104.553 -2.753 22.070 1.00 63.61 ? 260 ILE A CG1 1 ATOM 2033 C CG2 . ILE A 1 260 ? 104.960 -0.375 22.697 1.00 64.23 ? 260 ILE A CG2 1 ATOM 2034 C CD1 . ILE A 1 260 ? 105.155 -3.624 23.094 1.00 64.81 ? 260 ILE A CD1 1 ATOM 2035 N N . ILE A 1 261 ? 107.434 -0.035 20.030 1.00 62.22 ? 261 ILE A N 1 ATOM 2036 C CA . ILE A 1 261 ? 108.341 1.056 19.717 1.00 61.17 ? 261 ILE A CA 1 ATOM 2037 C C . ILE A 1 261 ? 107.962 1.713 18.414 1.00 60.77 ? 261 ILE A C 1 ATOM 2038 O O . ILE A 1 261 ? 107.835 2.936 18.378 1.00 60.53 ? 261 ILE A O 1 ATOM 2039 C CB . ILE A 1 261 ? 109.835 0.589 19.731 1.00 60.70 ? 261 ILE A CB 1 ATOM 2040 C CG1 . ILE A 1 261 ? 110.184 0.074 21.131 1.00 61.13 ? 261 ILE A CG1 1 ATOM 2041 C CG2 . ILE A 1 261 ? 110.781 1.728 19.327 1.00 58.93 ? 261 ILE A CG2 1 ATOM 2042 C CD1 . ILE A 1 261 ? 109.742 1.040 22.281 1.00 61.59 ? 261 ILE A CD1 1 ATOM 2043 N N . LYS A 1 262 ? 107.782 0.915 17.358 1.00 60.79 ? 262 LYS A N 1 ATOM 2044 C CA . LYS A 1 262 ? 107.406 1.470 16.050 1.00 61.08 ? 262 LYS A CA 1 ATOM 2045 C C . LYS A 1 262 ? 106.121 2.320 16.197 1.00 60.80 ? 262 LYS A C 1 ATOM 2046 O O . LYS A 1 262 ? 106.047 3.458 15.675 1.00 60.17 ? 262 LYS A O 1 ATOM 2047 C CB . LYS A 1 262 ? 107.295 0.385 14.965 1.00 61.16 ? 262 LYS A CB 1 ATOM 2048 C CG . LYS A 1 262 ? 106.808 0.928 13.612 1.00 61.71 ? 262 LYS A CG 1 ATOM 2049 C CD . LYS A 1 262 ? 106.792 -0.115 12.493 0.20 60.41 ? 262 LYS A CD 1 ATOM 2050 C CE . LYS A 1 262 ? 107.996 0.037 11.568 0.20 60.16 ? 262 LYS A CE 1 ATOM 2051 N NZ . LYS A 1 262 ? 107.684 -0.397 10.175 0.20 59.91 ? 262 LYS A NZ 1 ATOM 2052 N N . CYS A 1 263 ? 105.149 1.804 16.960 1.00 60.59 ? 263 CYS A N 1 ATOM 2053 C CA . CYS A 1 263 ? 103.954 2.590 17.253 1.00 61.26 ? 263 CYS A CA 1 ATOM 2054 C C . CYS A 1 263 ? 104.287 3.918 17.951 1.00 60.52 ? 263 CYS A C 1 ATOM 2055 O O . CYS A 1 263 ? 103.800 4.990 17.543 1.00 59.98 ? 263 CYS A O 1 ATOM 2056 C CB . CYS A 1 263 ? 102.948 1.823 18.089 1.00 61.80 ? 263 CYS A CB 1 ATOM 2057 S SG . CYS A 1 263 ? 101.567 2.897 18.529 1.00 66.42 ? 263 CYS A SG 1 ATOM 2058 N N . LEU A 1 264 ? 105.119 3.841 18.998 1.00 59.36 ? 264 LEU A N 1 ATOM 2059 C CA . LEU A 1 264 ? 105.522 5.027 19.756 1.00 58.06 ? 264 LEU A CA 1 ATOM 2060 C C . LEU A 1 264 ? 106.321 6.041 18.923 1.00 57.24 ? 264 LEU A C 1 ATOM 2061 O O . LEU A 1 264 ? 106.258 7.218 19.159 1.00 57.04 ? 264 LEU A O 1 ATOM 2062 C CB . LEU A 1 264 ? 106.252 4.620 21.022 1.00 57.74 ? 264 LEU A CB 1 ATOM 2063 C CG . LEU A 1 264 ? 105.370 4.061 22.142 1.00 57.28 ? 264 LEU A CG 1 ATOM 2064 C CD1 . LEU A 1 264 ? 106.257 3.415 23.188 1.00 56.05 ? 264 LEU A CD1 1 ATOM 2065 C CD2 . LEU A 1 264 ? 104.485 5.108 22.792 1.00 54.31 ? 264 LEU A CD2 1 ATOM 2066 N N . ARG A 1 265 ? 107.040 5.581 17.921 1.00 57.23 ? 265 ARG A N 1 ATOM 2067 C CA . ARG A 1 265 ? 107.727 6.479 17.016 1.00 57.49 ? 265 ARG A CA 1 ATOM 2068 C C . ARG A 1 265 ? 106.772 7.276 16.121 1.00 58.27 ? 265 ARG A C 1 ATOM 2069 O O . ARG A 1 265 ? 107.221 8.112 15.327 1.00 58.33 ? 265 ARG A O 1 ATOM 2070 C CB . ARG A 1 265 ? 108.690 5.701 16.125 1.00 56.88 ? 265 ARG A CB 1 ATOM 2071 C CG . ARG A 1 265 ? 109.910 5.121 16.811 1.00 57.66 ? 265 ARG A CG 1 ATOM 2072 C CD . ARG A 1 265 ? 111.112 5.064 15.878 1.00 59.12 ? 265 ARG A CD 1 ATOM 2073 N NE . ARG A 1 265 ? 111.785 3.777 15.928 1.00 63.51 ? 265 ARG A NE 1 ATOM 2074 C CZ . ARG A 1 265 ? 111.369 2.668 15.296 1.00 66.59 ? 265 ARG A CZ 1 ATOM 2075 N NH1 . ARG A 1 265 ? 112.061 1.544 15.427 1.00 65.09 ? 265 ARG A NH1 1 ATOM 2076 N NH2 . ARG A 1 265 ? 110.272 2.673 14.529 1.00 68.16 ? 265 ARG A NH2 1 ATOM 2077 N N . ASN A 1 266 ? 105.472 6.993 16.207 1.00 58.86 ? 266 ASN A N 1 ATOM 2078 C CA . ASN A 1 266 ? 104.485 7.741 15.411 1.00 59.85 ? 266 ASN A CA 1 ATOM 2079 C C . ASN A 1 266 ? 103.687 8.748 16.168 1.00 59.29 ? 266 ASN A C 1 ATOM 2080 O O . ASN A 1 266 ? 103.058 9.593 15.577 1.00 59.83 ? 266 ASN A O 1 ATOM 2081 C CB . ASN A 1 266 ? 103.579 6.810 14.619 1.00 60.56 ? 266 ASN A CB 1 ATOM 2082 C CG . ASN A 1 266 ? 104.281 6.265 13.432 1.00 63.25 ? 266 ASN A CG 1 ATOM 2083 O OD1 . ASN A 1 266 ? 104.648 7.013 12.519 1.00 66.30 ? 266 ASN A OD1 1 ATOM 2084 N ND2 . ASN A 1 266 ? 104.550 4.963 13.451 1.00 67.78 ? 266 ASN A ND2 1 ATOM 2085 N N . LYS A 1 267 ? 103.752 8.677 17.486 1.00 59.59 ? 267 LYS A N 1 ATOM 2086 C CA . LYS A 1 267 ? 103.162 9.681 18.346 1.00 59.28 ? 267 LYS A CA 1 ATOM 2087 C C . LYS A 1 267 ? 103.891 11.001 18.224 1.00 59.17 ? 267 LYS A C 1 ATOM 2088 O O . LYS A 1 267 ? 105.090 11.019 18.021 1.00 59.13 ? 267 LYS A O 1 ATOM 2089 C CB . LYS A 1 267 ? 103.156 9.163 19.780 1.00 59.48 ? 267 LYS A CB 1 ATOM 2090 C CG . LYS A 1 267 ? 102.431 7.816 19.902 1.00 60.47 ? 267 LYS A CG 1 ATOM 2091 C CD . LYS A 1 267 ? 100.945 7.933 19.471 1.00 63.01 ? 267 LYS A CD 1 ATOM 2092 C CE . LYS A 1 267 ? 100.618 6.948 18.332 1.00 66.30 ? 267 LYS A CE 1 ATOM 2093 N NZ . LYS A 1 267 ? 99.174 6.567 18.336 1.00 69.19 ? 267 LYS A NZ 1 ATOM 2094 N N . ASP A 1 268 ? 103.155 12.115 18.297 1.00 59.52 ? 268 ASP A N 1 ATOM 2095 C CA . ASP A 1 268 ? 103.790 13.420 18.410 1.00 59.16 ? 268 ASP A CA 1 ATOM 2096 C C . ASP A 1 268 ? 104.577 13.405 19.728 1.00 57.93 ? 268 ASP A C 1 ATOM 2097 O O . ASP A 1 268 ? 104.064 12.906 20.747 1.00 57.28 ? 268 ASP A O 1 ATOM 2098 C CB . ASP A 1 268 ? 102.760 14.567 18.468 1.00 60.19 ? 268 ASP A CB 1 ATOM 2099 C CG . ASP A 1 268 ? 101.855 14.649 17.229 1.00 63.59 ? 268 ASP A CG 1 ATOM 2100 O OD1 . ASP A 1 268 ? 100.726 15.213 17.365 1.00 65.99 ? 268 ASP A OD1 1 ATOM 2101 O OD2 . ASP A 1 268 ? 102.167 14.199 16.094 1.00 65.08 ? 268 ASP A OD2 1 ATOM 2102 N N . PRO A 1 269 ? 105.774 13.988 19.737 1.00 56.97 ? 269 PRO A N 1 ATOM 2103 C CA . PRO A 1 269 ? 106.556 14.080 20.955 1.00 56.58 ? 269 PRO A CA 1 ATOM 2104 C C . PRO A 1 269 ? 105.698 14.577 22.105 1.00 56.09 ? 269 PRO A C 1 ATOM 2105 O O . PRO A 1 269 ? 105.895 14.158 23.220 1.00 56.07 ? 269 PRO A O 1 ATOM 2106 C CB . PRO A 1 269 ? 107.649 15.093 20.608 1.00 56.42 ? 269 PRO A CB 1 ATOM 2107 C CG . PRO A 1 269 ? 107.302 15.631 19.293 1.00 56.70 ? 269 PRO A CG 1 ATOM 2108 C CD . PRO A 1 269 ? 106.469 14.610 18.602 1.00 57.50 ? 269 PRO A CD 1 ATOM 2109 N N . GLN A 1 270 ? 104.711 15.416 21.818 1.00 56.20 ? 270 GLN A N 1 ATOM 2110 C CA . GLN A 1 270 ? 103.894 16.037 22.853 1.00 56.49 ? 270 GLN A CA 1 ATOM 2111 C C . GLN A 1 270 ? 102.885 15.057 23.454 1.00 56.01 ? 270 GLN A C 1 ATOM 2112 O O . GLN A 1 270 ? 102.530 15.176 24.618 1.00 56.01 ? 270 GLN A O 1 ATOM 2113 C CB . GLN A 1 270 ? 103.224 17.320 22.303 1.00 56.79 ? 270 GLN A CB 1 ATOM 2114 C CG . GLN A 1 270 ? 102.361 18.107 23.301 1.00 59.00 ? 270 GLN A CG 1 ATOM 2115 C CD . GLN A 1 270 ? 103.060 18.413 24.642 1.00 63.13 ? 270 GLN A CD 1 ATOM 2116 O OE1 . GLN A 1 270 ? 104.216 18.881 24.670 1.00 62.09 ? 270 GLN A OE1 1 ATOM 2117 N NE2 . GLN A 1 270 ? 102.359 18.147 25.750 1.00 61.85 ? 270 GLN A NE2 1 ATOM 2118 N N . GLU A 1 271 ? 102.460 14.056 22.689 1.00 56.11 ? 271 GLU A N 1 ATOM 2119 C CA . GLU A 1 271 ? 101.575 13.036 23.268 1.00 56.68 ? 271 GLU A CA 1 ATOM 2120 C C . GLU A 1 271 ? 102.353 12.082 24.178 1.00 56.34 ? 271 GLU A C 1 ATOM 2121 O O . GLU A 1 271 ? 101.811 11.586 25.197 1.00 56.57 ? 271 GLU A O 1 ATOM 2122 C CB . GLU A 1 271 ? 100.738 12.279 22.211 1.00 56.74 ? 271 GLU A CB 1 ATOM 2123 C CG . GLU A 1 271 ? 100.407 10.834 22.599 1.00 59.51 ? 271 GLU A CG 1 ATOM 2124 C CD . GLU A 1 271 ? 99.024 10.339 22.141 1.00 67.35 ? 271 GLU A CD 1 ATOM 2125 O OE1 . GLU A 1 271 ? 98.802 10.187 20.894 1.00 68.83 ? 271 GLU A OE1 1 ATOM 2126 O OE2 . GLU A 1 271 ? 98.164 10.065 23.040 1.00 67.82 ? 271 GLU A OE2 1 ATOM 2127 N N . ILE A 1 272 ? 103.605 11.806 23.814 1.00 55.30 ? 272 ILE A N 1 ATOM 2128 C CA . ILE A 1 272 ? 104.492 11.120 24.740 1.00 55.12 ? 272 ILE A CA 1 ATOM 2129 C C . ILE A 1 272 ? 104.708 11.881 26.062 1.00 54.39 ? 272 ILE A C 1 ATOM 2130 O O . ILE A 1 272 ? 104.566 11.275 27.122 1.00 54.22 ? 272 ILE A O 1 ATOM 2131 C CB . ILE A 1 272 ? 105.807 10.728 24.073 1.00 55.69 ? 272 ILE A CB 1 ATOM 2132 C CG1 . ILE A 1 272 ? 105.569 9.538 23.133 1.00 55.60 ? 272 ILE A CG1 1 ATOM 2133 C CG2 . ILE A 1 272 ? 106.850 10.350 25.152 1.00 55.98 ? 272 ILE A CG2 1 ATOM 2134 C CD1 . ILE A 1 272 ? 106.512 9.492 21.939 1.00 57.31 ? 272 ILE A CD1 1 ATOM 2135 N N . LEU A 1 273 ? 105.004 13.188 26.010 1.00 53.88 ? 273 LEU A N 1 ATOM 2136 C CA . LEU A 1 273 ? 105.264 13.981 27.236 1.00 53.59 ? 273 LEU A CA 1 ATOM 2137 C C . LEU A 1 273 ? 104.095 13.952 28.199 1.00 54.59 ? 273 LEU A C 1 ATOM 2138 O O . LEU A 1 273 ? 104.234 13.644 29.417 1.00 53.73 ? 273 LEU A O 1 ATOM 2139 C CB . LEU A 1 273 ? 105.596 15.428 26.891 1.00 52.95 ? 273 LEU A CB 1 ATOM 2140 C CG . LEU A 1 273 ? 106.964 15.708 26.266 1.00 52.98 ? 273 LEU A CG 1 ATOM 2141 C CD1 . LEU A 1 273 ? 107.204 17.202 25.834 1.00 49.75 ? 273 LEU A CD1 1 ATOM 2142 C CD2 . LEU A 1 273 ? 108.088 15.220 27.217 1.00 49.24 ? 273 LEU A CD2 1 ATOM 2143 N N . LEU A 1 274 ? 102.930 14.268 27.621 1.00 55.66 ? 274 LEU A N 1 ATOM 2144 C CA . LEU A 1 274 ? 101.618 14.166 28.241 1.00 56.62 ? 274 LEU A CA 1 ATOM 2145 C C . LEU A 1 274 ? 101.431 12.903 29.080 1.00 56.31 ? 274 LEU A C 1 ATOM 2146 O O . LEU A 1 274 ? 100.961 12.941 30.215 1.00 56.63 ? 274 LEU A O 1 ATOM 2147 C CB . LEU A 1 274 ? 100.622 14.078 27.097 1.00 57.60 ? 274 LEU A CB 1 ATOM 2148 C CG . LEU A 1 274 ? 99.335 14.871 27.067 1.00 60.16 ? 274 LEU A CG 1 ATOM 2149 C CD1 . LEU A 1 274 ? 99.539 16.183 26.240 1.00 60.75 ? 274 LEU A CD1 1 ATOM 2150 C CD2 . LEU A 1 274 ? 98.220 13.970 26.467 1.00 62.59 ? 274 LEU A CD2 1 ATOM 2151 N N . ASN A 1 275 ? 101.769 11.764 28.506 1.00 56.85 ? 275 ASN A N 1 ATOM 2152 C CA . ASN A 1 275 ? 101.500 10.491 29.173 1.00 57.55 ? 275 ASN A CA 1 ATOM 2153 C C . ASN A 1 275 ? 102.602 9.907 30.082 1.00 57.91 ? 275 ASN A C 1 ATOM 2154 O O . ASN A 1 275 ? 102.334 8.947 30.817 1.00 58.31 ? 275 ASN A O 1 ATOM 2155 C CB . ASN A 1 275 ? 100.977 9.475 28.154 1.00 57.34 ? 275 ASN A CB 1 ATOM 2156 C CG . ASN A 1 275 ? 99.613 9.884 27.601 1.00 58.08 ? 275 ASN A CG 1 ATOM 2157 O OD1 . ASN A 1 275 ? 99.468 10.220 26.411 1.00 58.65 ? 275 ASN A OD1 1 ATOM 2158 N ND2 . ASN A 1 275 ? 98.629 9.936 28.480 1.00 56.26 ? 275 ASN A ND2 1 ATOM 2159 N N . GLU A 1 276 ? 103.810 10.488 30.029 1.00 57.62 ? 276 GLU A N 1 ATOM 2160 C CA . GLU A 1 276 ? 104.916 10.147 30.937 1.00 57.68 ? 276 GLU A CA 1 ATOM 2161 C C . GLU A 1 276 ? 104.541 10.163 32.423 1.00 58.47 ? 276 GLU A C 1 ATOM 2162 O O . GLU A 1 276 ? 104.988 9.297 33.179 1.00 58.12 ? 276 GLU A O 1 ATOM 2163 C CB . GLU A 1 276 ? 106.077 11.121 30.759 1.00 57.18 ? 276 GLU A CB 1 ATOM 2164 C CG . GLU A 1 276 ? 106.891 10.942 29.503 1.00 57.02 ? 276 GLU A CG 1 ATOM 2165 C CD . GLU A 1 276 ? 108.129 11.829 29.460 1.00 58.29 ? 276 GLU A CD 1 ATOM 2166 O OE1 . GLU A 1 276 ? 108.378 12.646 30.390 1.00 58.93 ? 276 GLU A OE1 1 ATOM 2167 O OE2 . GLU A 1 276 ? 108.873 11.709 28.479 1.00 58.39 ? 276 GLU A OE2 1 ATOM 2168 N N . ALA A 1 277 ? 103.742 11.149 32.845 1.00 59.53 ? 277 ALA A N 1 ATOM 2169 C CA . ALA A 1 277 ? 103.453 11.361 34.279 1.00 60.88 ? 277 ALA A CA 1 ATOM 2170 C C . ALA A 1 277 ? 102.650 10.226 34.907 1.00 62.22 ? 277 ALA A C 1 ATOM 2171 O O . ALA A 1 277 ? 102.775 9.936 36.124 1.00 63.25 ? 277 ALA A O 1 ATOM 2172 C CB . ALA A 1 277 ? 102.754 12.696 34.499 1.00 60.77 ? 277 ALA A CB 1 ATOM 2173 N N . PHE A 1 278 ? 101.871 9.540 34.070 1.00 62.63 ? 278 PHE A N 1 ATOM 2174 C CA . PHE A 1 278 ? 100.890 8.578 34.555 1.00 62.57 ? 278 PHE A CA 1 ATOM 2175 C C . PHE A 1 278 ? 101.355 7.134 34.491 1.00 62.65 ? 278 PHE A C 1 ATOM 2176 O O . PHE A 1 278 ? 100.593 6.230 34.833 1.00 62.78 ? 278 PHE A O 1 ATOM 2177 C CB . PHE A 1 278 ? 99.575 8.770 33.797 1.00 62.80 ? 278 PHE A CB 1 ATOM 2178 C CG . PHE A 1 278 ? 99.099 10.172 33.820 1.00 65.04 ? 278 PHE A CG 1 ATOM 2179 C CD1 . PHE A 1 278 ? 99.392 11.032 32.774 1.00 66.93 ? 278 PHE A CD1 1 ATOM 2180 C CD2 . PHE A 1 278 ? 98.409 10.662 34.923 1.00 67.42 ? 278 PHE A CD2 1 ATOM 2181 C CE1 . PHE A 1 278 ? 98.993 12.356 32.809 1.00 69.51 ? 278 PHE A CE1 1 ATOM 2182 C CE2 . PHE A 1 278 ? 97.993 11.992 34.968 1.00 69.15 ? 278 PHE A CE2 1 ATOM 2183 C CZ . PHE A 1 278 ? 98.291 12.841 33.913 1.00 70.90 ? 278 PHE A CZ 1 ATOM 2184 N N . VAL A 1 279 ? 102.603 6.908 34.089 1.00 62.41 ? 279 VAL A N 1 ATOM 2185 C CA . VAL A 1 279 ? 103.107 5.531 33.948 1.00 62.71 ? 279 VAL A CA 1 ATOM 2186 C C . VAL A 1 279 ? 103.315 4.786 35.281 1.00 63.07 ? 279 VAL A C 1 ATOM 2187 O O . VAL A 1 279 ? 103.501 3.568 35.292 1.00 63.25 ? 279 VAL A O 1 ATOM 2188 C CB . VAL A 1 279 ? 104.366 5.457 33.060 1.00 63.11 ? 279 VAL A CB 1 ATOM 2189 C CG1 . VAL A 1 279 ? 104.051 5.987 31.666 1.00 62.03 ? 279 VAL A CG1 1 ATOM 2190 C CG2 . VAL A 1 279 ? 105.566 6.205 33.699 1.00 61.31 ? 279 VAL A CG2 1 ATOM 2191 N N . VAL A 1 280 ? 103.282 5.547 36.378 1.00 63.45 ? 280 VAL A N 1 ATOM 2192 C CA . VAL A 1 280 ? 103.347 5.072 37.775 1.00 63.41 ? 280 VAL A CA 1 ATOM 2193 C C . VAL A 1 280 ? 102.018 5.432 38.462 1.00 63.67 ? 280 VAL A C 1 ATOM 2194 O O . VAL A 1 280 ? 101.522 6.567 38.314 1.00 64.05 ? 280 VAL A O 1 ATOM 2195 C CB . VAL A 1 280 ? 104.494 5.781 38.604 1.00 63.82 ? 280 VAL A CB 1 ATOM 2196 C CG1 . VAL A 1 280 ? 105.835 5.055 38.478 1.00 62.68 ? 280 VAL A CG1 1 ATOM 2197 C CG2 . VAL A 1 280 ? 104.614 7.274 38.239 1.00 63.38 ? 280 VAL A CG2 1 ATOM 2198 N N . PRO A 1 281 ? 101.430 4.497 39.209 1.00 63.26 ? 281 PRO A N 1 ATOM 2199 C CA . PRO A 1 281 ? 100.140 4.772 39.877 1.00 63.07 ? 281 PRO A CA 1 ATOM 2200 C C . PRO A 1 281 ? 100.263 5.883 40.907 1.00 62.28 ? 281 PRO A C 1 ATOM 2201 O O . PRO A 1 281 ? 99.361 6.704 41.021 1.00 62.18 ? 281 PRO A O 1 ATOM 2202 C CB . PRO A 1 281 ? 99.766 3.439 40.548 1.00 63.51 ? 281 PRO A CB 1 ATOM 2203 C CG . PRO A 1 281 ? 101.011 2.624 40.558 1.00 63.72 ? 281 PRO A CG 1 ATOM 2204 C CD . PRO A 1 281 ? 101.933 3.141 39.478 1.00 63.67 ? 281 PRO A CD 1 ATOM 2205 N N A TYR A 1 282 ? 101.353 5.880 41.674 0.50 62.16 ? 282 TYR A N 1 ATOM 2206 N N B TYR A 1 282 ? 101.392 5.922 41.614 0.20 61.63 ? 282 TYR A N 1 ATOM 2207 C CA A TYR A 1 282 ? 101.609 6.971 42.608 0.50 61.92 ? 282 TYR A CA 1 ATOM 2208 C CA B TYR A 1 282 ? 101.634 6.918 42.656 0.20 60.92 ? 282 TYR A CA 1 ATOM 2209 C C A TYR A 1 282 ? 103.032 7.516 42.509 0.50 61.10 ? 282 TYR A C 1 ATOM 2210 C C B TYR A 1 282 ? 103.043 7.520 42.550 0.20 60.45 ? 282 TYR A C 1 ATOM 2211 O O A TYR A 1 282 ? 104.011 6.819 42.772 0.50 61.42 ? 282 TYR A O 1 ATOM 2212 O O B TYR A 1 282 ? 104.034 6.853 42.856 0.20 60.63 ? 282 TYR A O 1 ATOM 2213 C CB A TYR A 1 282 ? 101.213 6.613 44.059 0.50 62.15 ? 282 TYR A CB 1 ATOM 2214 C CB B TYR A 1 282 ? 101.396 6.299 44.046 0.20 60.76 ? 282 TYR A CB 1 ATOM 2215 C CG A TYR A 1 282 ? 100.498 7.771 44.747 0.50 64.56 ? 282 TYR A CG 1 ATOM 2216 C CG B TYR A 1 282 ? 99.985 5.777 44.257 0.20 60.62 ? 282 TYR A CG 1 ATOM 2217 C CD1 A TYR A 1 282 ? 101.103 8.487 45.787 0.50 65.78 ? 282 TYR A CD1 1 ATOM 2218 C CD1 B TYR A 1 282 ? 98.957 6.633 44.657 0.20 60.46 ? 282 TYR A CD1 1 ATOM 2219 C CD2 A TYR A 1 282 ? 99.224 8.185 44.315 0.50 66.47 ? 282 TYR A CD2 1 ATOM 2220 C CD2 B TYR A 1 282 ? 99.675 4.431 44.049 0.20 60.39 ? 282 TYR A CD2 1 ATOM 2221 C CE1 A TYR A 1 282 ? 100.449 9.570 46.404 0.50 66.39 ? 282 TYR A CE1 1 ATOM 2222 C CE1 B TYR A 1 282 ? 97.660 6.167 44.846 0.20 59.96 ? 282 TYR A CE1 1 ATOM 2223 C CE2 A TYR A 1 282 ? 98.562 9.265 44.923 0.50 67.18 ? 282 TYR A CE2 1 ATOM 2224 C CE2 B TYR A 1 282 ? 98.379 3.952 44.235 0.20 60.09 ? 282 TYR A CE2 1 ATOM 2225 C CZ A TYR A 1 282 ? 99.181 9.953 45.964 0.50 67.69 ? 282 TYR A CZ 1 ATOM 2226 C CZ B TYR A 1 282 ? 97.378 4.828 44.636 0.20 60.31 ? 282 TYR A CZ 1 ATOM 2227 O OH A TYR A 1 282 ? 98.528 11.018 46.555 0.50 66.91 ? 282 TYR A OH 1 ATOM 2228 O OH B TYR A 1 282 ? 96.094 4.372 44.828 0.20 60.09 ? 282 TYR A OH 1 ATOM 2229 N N . GLY A 1 283 ? 103.131 8.777 42.113 1.00 60.11 ? 283 GLY A N 1 ATOM 2230 C CA . GLY A 1 283 ? 104.425 9.443 41.998 1.00 58.23 ? 283 GLY A CA 1 ATOM 2231 C C . GLY A 1 283 ? 104.760 10.321 43.196 1.00 56.67 ? 283 GLY A C 1 ATOM 2232 O O . GLY A 1 283 ? 103.889 10.659 44.011 1.00 56.20 ? 283 GLY A O 1 ATOM 2233 N N . THR A 1 284 ? 106.025 10.701 43.319 1.00 54.34 ? 284 THR A N 1 ATOM 2234 C CA . THR A 1 284 ? 106.363 11.703 44.318 1.00 52.33 ? 284 THR A CA 1 ATOM 2235 C C . THR A 1 284 ? 106.903 12.937 43.585 1.00 50.42 ? 284 THR A C 1 ATOM 2236 O O . THR A 1 284 ? 107.113 12.865 42.363 1.00 49.36 ? 284 THR A O 1 ATOM 2237 C CB . THR A 1 284 ? 107.351 11.128 45.366 1.00 52.27 ? 284 THR A CB 1 ATOM 2238 O OG1 . THR A 1 284 ? 108.580 10.785 44.728 1.00 54.61 ? 284 THR A OG1 1 ATOM 2239 C CG2 . THR A 1 284 ? 106.880 9.766 45.866 1.00 52.75 ? 284 THR A CG2 1 ATOM 2240 N N . PRO A 1 285 ? 107.099 14.058 44.302 1.00 48.85 ? 285 PRO A N 1 ATOM 2241 C CA . PRO A 1 285 ? 107.791 15.232 43.769 1.00 48.13 ? 285 PRO A CA 1 ATOM 2242 C C . PRO A 1 285 ? 109.215 14.893 43.352 1.00 48.34 ? 285 PRO A C 1 ATOM 2243 O O . PRO A 1 285 ? 109.896 15.731 42.764 1.00 48.96 ? 285 PRO A O 1 ATOM 2244 C CB . PRO A 1 285 ? 107.910 16.115 44.996 1.00 48.04 ? 285 PRO A CB 1 ATOM 2245 C CG . PRO A 1 285 ? 106.795 15.736 45.799 1.00 47.77 ? 285 PRO A CG 1 ATOM 2246 C CD . PRO A 1 285 ? 106.674 14.288 45.691 1.00 48.36 ? 285 PRO A CD 1 ATOM 2247 N N . LEU A 1 286 ? 109.667 13.690 43.712 1.00 47.44 ? 286 LEU A N 1 ATOM 2248 C CA . LEU A 1 286 ? 110.988 13.203 43.393 1.00 48.21 ? 286 LEU A CA 1 ATOM 2249 C C . LEU A 1 286 ? 110.942 12.087 42.373 1.00 48.42 ? 286 LEU A C 1 ATOM 2250 O O . LEU A 1 286 ? 111.900 11.337 42.270 1.00 49.14 ? 286 LEU A O 1 ATOM 2251 C CB . LEU A 1 286 ? 111.673 12.680 44.646 1.00 47.67 ? 286 LEU A CB 1 ATOM 2252 C CG . LEU A 1 286 ? 112.351 13.829 45.352 1.00 47.67 ? 286 LEU A CG 1 ATOM 2253 C CD1 . LEU A 1 286 ? 111.814 13.889 46.758 1.00 48.56 ? 286 LEU A CD1 1 ATOM 2254 C CD2 . LEU A 1 286 ? 113.867 13.696 45.253 1.00 46.32 ? 286 LEU A CD2 1 ATOM 2255 N N . SER A 1 287 ? 109.849 11.991 41.616 1.00 48.08 ? 287 SER A N 1 ATOM 2256 C CA . SER A 1 287 ? 109.691 10.889 40.652 1.00 47.78 ? 287 SER A CA 1 ATOM 2257 C C . SER A 1 287 ? 110.638 10.989 39.461 1.00 45.96 ? 287 SER A C 1 ATOM 2258 O O . SER A 1 287 ? 110.803 12.043 38.852 1.00 46.04 ? 287 SER A O 1 ATOM 2259 C CB . SER A 1 287 ? 108.225 10.762 40.159 1.00 47.76 ? 287 SER A CB 1 ATOM 2260 O OG . SER A 1 287 ? 107.542 9.702 40.836 1.00 48.13 ? 287 SER A OG 1 ATOM 2261 N N . VAL A 1 288 ? 111.263 9.876 39.146 1.00 44.22 ? 288 VAL A N 1 ATOM 2262 C CA . VAL A 1 288 ? 112.057 9.798 37.962 1.00 42.66 ? 288 VAL A CA 1 ATOM 2263 C C . VAL A 1 288 ? 111.364 8.667 37.224 1.00 43.81 ? 288 VAL A C 1 ATOM 2264 O O . VAL A 1 288 ? 111.712 7.517 37.433 1.00 44.52 ? 288 VAL A O 1 ATOM 2265 C CB . VAL A 1 288 ? 113.526 9.422 38.329 1.00 42.77 ? 288 VAL A CB 1 ATOM 2266 C CG1 . VAL A 1 288 ? 114.310 9.048 37.125 1.00 36.82 ? 288 VAL A CG1 1 ATOM 2267 C CG2 . VAL A 1 288 ? 114.209 10.594 39.118 1.00 40.59 ? 288 VAL A CG2 1 ATOM 2268 N N . ASN A 1 289 ? 110.376 9.003 36.388 1.00 43.46 ? 289 ASN A N 1 ATOM 2269 C CA . ASN A 1 289 ? 109.562 8.008 35.705 1.00 43.59 ? 289 ASN A CA 1 ATOM 2270 C C . ASN A 1 289 ? 110.448 7.199 34.768 1.00 41.99 ? 289 ASN A C 1 ATOM 2271 O O . ASN A 1 289 ? 110.314 5.982 34.701 1.00 41.23 ? 289 ASN A O 1 ATOM 2272 C CB . ASN A 1 289 ? 108.444 8.680 34.865 1.00 44.27 ? 289 ASN A CB 1 ATOM 2273 C CG . ASN A 1 289 ? 107.382 9.380 35.712 1.00 48.44 ? 289 ASN A CG 1 ATOM 2274 O OD1 . ASN A 1 289 ? 106.860 8.808 36.685 1.00 50.11 ? 289 ASN A OD1 1 ATOM 2275 N ND2 . ASN A 1 289 ? 107.065 10.646 35.346 1.00 47.88 ? 289 ASN A ND2 1 ATOM 2276 N N . PHE A 1 290 ? 111.312 7.889 34.017 1.00 41.08 ? 290 PHE A N 1 ATOM 2277 C CA . PHE A 1 290 ? 112.170 7.266 33.009 1.00 40.40 ? 290 PHE A CA 1 ATOM 2278 C C . PHE A 1 290 ? 113.576 7.703 33.267 1.00 40.57 ? 290 PHE A C 1 ATOM 2279 O O . PHE A 1 290 ? 113.957 8.833 32.917 1.00 40.67 ? 290 PHE A O 1 ATOM 2280 C CB . PHE A 1 290 ? 111.744 7.646 31.588 1.00 39.94 ? 290 PHE A CB 1 ATOM 2281 C CG . PHE A 1 290 ? 110.392 7.081 31.207 1.00 44.49 ? 290 PHE A CG 1 ATOM 2282 C CD1 . PHE A 1 290 ? 110.272 5.729 30.797 1.00 44.47 ? 290 PHE A CD1 1 ATOM 2283 C CD2 . PHE A 1 290 ? 109.221 7.863 31.349 1.00 45.83 ? 290 PHE A CD2 1 ATOM 2284 C CE1 . PHE A 1 290 ? 109.022 5.181 30.499 1.00 47.26 ? 290 PHE A CE1 1 ATOM 2285 C CE2 . PHE A 1 290 ? 107.938 7.325 31.036 1.00 43.58 ? 290 PHE A CE2 1 ATOM 2286 C CZ . PHE A 1 290 ? 107.832 6.004 30.613 1.00 44.78 ? 290 PHE A CZ 1 ATOM 2287 N N . GLY A 1 291 ? 114.358 6.799 33.857 1.00 40.47 ? 291 GLY A N 1 ATOM 2288 C CA . GLY A 1 291 ? 115.785 7.070 34.168 1.00 40.84 ? 291 GLY A CA 1 ATOM 2289 C C . GLY A 1 291 ? 116.765 5.993 33.733 1.00 39.72 ? 291 GLY A C 1 ATOM 2290 O O . GLY A 1 291 ? 116.403 5.107 32.971 1.00 41.11 ? 291 GLY A O 1 ATOM 2291 N N . PRO A 1 292 ? 118.010 6.073 34.185 1.00 39.00 ? 292 PRO A N 1 ATOM 2292 C CA . PRO A 1 292 ? 119.014 5.041 33.850 1.00 37.94 ? 292 PRO A CA 1 ATOM 2293 C C . PRO A 1 292 ? 118.586 3.639 34.202 1.00 37.45 ? 292 PRO A C 1 ATOM 2294 O O . PRO A 1 292 ? 117.925 3.423 35.203 1.00 36.93 ? 292 PRO A O 1 ATOM 2295 C CB . PRO A 1 292 ? 120.257 5.458 34.686 1.00 36.96 ? 292 PRO A CB 1 ATOM 2296 C CG . PRO A 1 292 ? 120.072 6.956 34.917 1.00 37.56 ? 292 PRO A CG 1 ATOM 2297 C CD . PRO A 1 292 ? 118.584 7.159 35.012 1.00 38.55 ? 292 PRO A CD 1 ATOM 2298 N N . THR A 1 293 ? 118.945 2.683 33.364 1.00 38.44 ? 293 THR A N 1 ATOM 2299 C CA . THR A 1 293 ? 118.682 1.254 33.690 1.00 39.38 ? 293 THR A CA 1 ATOM 2300 C C . THR A 1 293 ? 119.973 0.434 33.570 1.00 39.84 ? 293 THR A C 1 ATOM 2301 O O . THR A 1 293 ? 120.970 0.910 33.030 1.00 39.82 ? 293 THR A O 1 ATOM 2302 C CB . THR A 1 293 ? 117.588 0.594 32.801 1.00 38.76 ? 293 THR A CB 1 ATOM 2303 O OG1 . THR A 1 293 ? 117.689 1.074 31.450 1.00 35.20 ? 293 THR A OG1 1 ATOM 2304 C CG2 . THR A 1 293 ? 116.267 1.010 33.243 1.00 40.78 ? 293 THR A CG2 1 ATOM 2305 N N . VAL A 1 294 ? 119.958 -0.779 34.105 1.00 41.08 ? 294 VAL A N 1 ATOM 2306 C CA . VAL A 1 294 ? 121.013 -1.731 33.764 1.00 42.81 ? 294 VAL A CA 1 ATOM 2307 C C . VAL A 1 294 ? 120.633 -2.256 32.389 1.00 43.52 ? 294 VAL A C 1 ATOM 2308 O O . VAL A 1 294 ? 119.681 -3.016 32.245 1.00 45.47 ? 294 VAL A O 1 ATOM 2309 C CB . VAL A 1 294 ? 121.151 -2.887 34.825 1.00 42.97 ? 294 VAL A CB 1 ATOM 2310 C CG1 . VAL A 1 294 ? 122.282 -3.850 34.450 1.00 42.93 ? 294 VAL A CG1 1 ATOM 2311 C CG2 . VAL A 1 294 ? 121.387 -2.293 36.234 1.00 41.69 ? 294 VAL A CG2 1 ATOM 2312 N N . ASP A 1 295 ? 121.346 -1.818 31.381 1.00 44.43 ? 295 ASP A N 1 ATOM 2313 C CA . ASP A 1 295 ? 121.007 -2.134 29.995 1.00 46.21 ? 295 ASP A CA 1 ATOM 2314 C C . ASP A 1 295 ? 121.954 -3.224 29.341 1.00 47.11 ? 295 ASP A C 1 ATOM 2315 O O . ASP A 1 295 ? 121.787 -3.589 28.188 1.00 46.87 ? 295 ASP A O 1 ATOM 2316 C CB . ASP A 1 295 ? 121.049 -0.834 29.187 1.00 44.60 ? 295 ASP A CB 1 ATOM 2317 C CG . ASP A 1 295 ? 122.408 -0.180 29.221 1.00 46.59 ? 295 ASP A CG 1 ATOM 2318 O OD1 . ASP A 1 295 ? 123.233 -0.538 30.092 1.00 48.83 ? 295 ASP A OD1 1 ATOM 2319 O OD2 . ASP A 1 295 ? 122.788 0.689 28.417 1.00 46.46 ? 295 ASP A OD2 1 ATOM 2320 N N . GLY A 1 296 ? 122.968 -3.698 30.071 1.00 47.69 ? 296 GLY A N 1 ATOM 2321 C CA . GLY A 1 296 ? 123.986 -4.571 29.491 1.00 47.47 ? 296 GLY A CA 1 ATOM 2322 C C . GLY A 1 296 ? 124.880 -3.878 28.485 1.00 47.83 ? 296 GLY A C 1 ATOM 2323 O O . GLY A 1 296 ? 125.656 -4.526 27.786 1.00 48.99 ? 296 GLY A O 1 ATOM 2324 N N . ASP A 1 297 ? 124.789 -2.555 28.397 1.00 47.31 ? 297 ASP A N 1 ATOM 2325 C CA . ASP A 1 297 ? 125.613 -1.813 27.442 1.00 44.94 ? 297 ASP A CA 1 ATOM 2326 C C . ASP A 1 297 ? 126.366 -0.685 28.182 1.00 44.16 ? 297 ASP A C 1 ATOM 2327 O O . ASP A 1 297 ? 127.568 -0.803 28.424 1.00 43.88 ? 297 ASP A O 1 ATOM 2328 C CB . ASP A 1 297 ? 124.735 -1.325 26.280 1.00 44.52 ? 297 ASP A CB 1 ATOM 2329 C CG . ASP A 1 297 ? 125.542 -0.781 25.102 1.00 45.36 ? 297 ASP A CG 1 ATOM 2330 O OD1 . ASP A 1 297 ? 126.804 -0.719 25.134 1.00 47.47 ? 297 ASP A OD1 1 ATOM 2331 O OD2 . ASP A 1 297 ? 124.971 -0.372 24.071 1.00 48.43 ? 297 ASP A OD2 1 ATOM 2332 N N . PHE A 1 298 ? 125.655 0.363 28.602 1.00 43.24 ? 298 PHE A N 1 ATOM 2333 C CA . PHE A 1 298 ? 126.266 1.481 29.321 1.00 42.36 ? 298 PHE A CA 1 ATOM 2334 C C . PHE A 1 298 ? 126.593 0.973 30.691 1.00 42.47 ? 298 PHE A C 1 ATOM 2335 O O . PHE A 1 298 ? 127.656 1.242 31.203 1.00 42.99 ? 298 PHE A O 1 ATOM 2336 C CB . PHE A 1 298 ? 125.303 2.686 29.457 1.00 41.47 ? 298 PHE A CB 1 ATOM 2337 C CG . PHE A 1 298 ? 125.962 3.938 29.988 1.00 39.62 ? 298 PHE A CG 1 ATOM 2338 C CD1 . PHE A 1 298 ? 125.887 4.268 31.354 1.00 36.86 ? 298 PHE A CD1 1 ATOM 2339 C CD2 . PHE A 1 298 ? 126.660 4.786 29.130 1.00 35.00 ? 298 PHE A CD2 1 ATOM 2340 C CE1 . PHE A 1 298 ? 126.526 5.411 31.846 1.00 35.19 ? 298 PHE A CE1 1 ATOM 2341 C CE2 . PHE A 1 298 ? 127.282 5.918 29.611 1.00 35.54 ? 298 PHE A CE2 1 ATOM 2342 C CZ . PHE A 1 298 ? 127.197 6.243 30.974 1.00 35.29 ? 298 PHE A CZ 1 ATOM 2343 N N . LEU A 1 299 ? 125.663 0.214 31.243 1.00 42.94 ? 299 LEU A N 1 ATOM 2344 C CA . LEU A 1 299 ? 125.694 -0.216 32.596 1.00 44.52 ? 299 LEU A CA 1 ATOM 2345 C C . LEU A 1 299 ? 125.560 -1.762 32.627 1.00 44.70 ? 299 LEU A C 1 ATOM 2346 O O . LEU A 1 299 ? 124.460 -2.319 32.478 1.00 43.24 ? 299 LEU A O 1 ATOM 2347 C CB . LEU A 1 299 ? 124.515 0.431 33.315 1.00 45.26 ? 299 LEU A CB 1 ATOM 2348 C CG . LEU A 1 299 ? 124.644 1.090 34.693 1.00 49.36 ? 299 LEU A CG 1 ATOM 2349 C CD1 . LEU A 1 299 ? 123.273 1.536 35.256 1.00 50.60 ? 299 LEU A CD1 1 ATOM 2350 C CD2 . LEU A 1 299 ? 125.389 0.215 35.711 1.00 51.53 ? 299 LEU A CD2 1 ATOM 2351 N N . THR A 1 300 ? 126.677 -2.453 32.853 1.00 44.94 ? 300 THR A N 1 ATOM 2352 C CA . THR A 1 300 ? 126.703 -3.918 32.770 1.00 45.94 ? 300 THR A CA 1 ATOM 2353 C C . THR A 1 300 ? 126.132 -4.689 33.941 1.00 45.01 ? 300 THR A C 1 ATOM 2354 O O . THR A 1 300 ? 125.993 -5.893 33.845 1.00 45.97 ? 300 THR A O 1 ATOM 2355 C CB . THR A 1 300 ? 128.134 -4.384 32.598 1.00 47.11 ? 300 THR A CB 1 ATOM 2356 O OG1 . THR A 1 300 ? 128.829 -4.265 33.860 1.00 49.87 ? 300 THR A OG1 1 ATOM 2357 C CG2 . THR A 1 300 ? 128.872 -3.384 31.690 1.00 48.99 ? 300 THR A CG2 1 ATOM 2358 N N . ASP A 1 301 ? 125.850 -4.042 35.066 1.00 44.20 ? 301 ASP A N 1 ATOM 2359 C CA . ASP A 1 301 ? 125.400 -4.778 36.253 1.00 42.95 ? 301 ASP A CA 1 ATOM 2360 C C . ASP A 1 301 ? 124.818 -3.743 37.193 1.00 42.70 ? 301 ASP A C 1 ATOM 2361 O O . ASP A 1 301 ? 124.978 -2.578 36.985 1.00 42.19 ? 301 ASP A O 1 ATOM 2362 C CB . ASP A 1 301 ? 126.599 -5.519 36.876 1.00 42.65 ? 301 ASP A CB 1 ATOM 2363 C CG . ASP A 1 301 ? 126.190 -6.614 37.929 1.00 44.69 ? 301 ASP A CG 1 ATOM 2364 O OD1 . ASP A 1 301 ? 127.119 -7.340 38.403 1.00 44.03 ? 301 ASP A OD1 1 ATOM 2365 O OD2 . ASP A 1 301 ? 125.013 -6.809 38.329 1.00 41.61 ? 301 ASP A OD2 1 ATOM 2366 N N . MET A 1 302 ? 124.112 -4.165 38.216 1.00 43.19 ? 302 MET A N 1 ATOM 2367 C CA . MET A 1 302 ? 123.611 -3.235 39.202 1.00 43.74 ? 302 MET A CA 1 ATOM 2368 C C . MET A 1 302 ? 124.718 -2.385 39.762 1.00 43.02 ? 302 MET A C 1 ATOM 2369 O O . MET A 1 302 ? 125.684 -2.890 40.266 1.00 42.23 ? 302 MET A O 1 ATOM 2370 C CB . MET A 1 302 ? 122.858 -3.992 40.274 1.00 44.74 ? 302 MET A CB 1 ATOM 2371 C CG . MET A 1 302 ? 121.813 -4.897 39.620 1.00 48.34 ? 302 MET A CG 1 ATOM 2372 S SD . MET A 1 302 ? 120.875 -5.868 40.816 1.00 57.36 ? 302 MET A SD 1 ATOM 2373 C CE . MET A 1 302 ? 119.931 -4.447 41.504 1.00 56.86 ? 302 MET A CE 1 ATOM 2374 N N . PRO A 1 303 ? 124.601 -1.067 39.599 1.00 43.73 ? 303 PRO A N 1 ATOM 2375 C CA . PRO A 1 303 ? 125.718 -0.179 39.912 1.00 42.92 ? 303 PRO A CA 1 ATOM 2376 C C . PRO A 1 303 ? 126.201 -0.318 41.394 1.00 42.84 ? 303 PRO A C 1 ATOM 2377 O O . PRO A 1 303 ? 127.396 -0.178 41.675 1.00 41.94 ? 303 PRO A O 1 ATOM 2378 C CB . PRO A 1 303 ? 125.162 1.226 39.573 1.00 42.91 ? 303 PRO A CB 1 ATOM 2379 C CG . PRO A 1 303 ? 123.677 1.078 39.490 1.00 42.49 ? 303 PRO A CG 1 ATOM 2380 C CD . PRO A 1 303 ? 123.412 -0.336 39.081 1.00 42.47 ? 303 PRO A CD 1 ATOM 2381 N N . ASP A 1 304 ? 125.287 -0.622 42.305 1.00 41.96 ? 304 ASP A N 1 ATOM 2382 C CA . ASP A 1 304 ? 125.620 -0.886 43.703 1.00 42.15 ? 304 ASP A CA 1 ATOM 2383 C C . ASP A 1 304 ? 126.638 -2.018 43.842 1.00 43.02 ? 304 ASP A C 1 ATOM 2384 O O . ASP A 1 304 ? 127.491 -2.000 44.750 1.00 42.99 ? 304 ASP A O 1 ATOM 2385 C CB . ASP A 1 304 ? 124.364 -1.281 44.496 1.00 42.62 ? 304 ASP A CB 1 ATOM 2386 C CG . ASP A 1 304 ? 123.426 -2.245 43.723 0.50 44.21 ? 304 ASP A CG 1 ATOM 2387 O OD1 . ASP A 1 304 ? 123.140 -2.004 42.527 0.50 45.89 ? 304 ASP A OD1 1 ATOM 2388 O OD2 . ASP A 1 304 ? 122.870 -3.242 44.247 0.50 45.38 ? 304 ASP A OD2 1 ATOM 2389 N N . ILE A 1 305 ? 126.523 -3.023 42.965 1.00 41.59 ? 305 ILE A N 1 ATOM 2390 C CA . ILE A 1 305 ? 127.411 -4.176 43.019 1.00 39.99 ? 305 ILE A CA 1 ATOM 2391 C C . ILE A 1 305 ? 128.774 -3.707 42.519 1.00 40.64 ? 305 ILE A C 1 ATOM 2392 O O . ILE A 1 305 ? 129.775 -3.984 43.180 1.00 40.36 ? 305 ILE A O 1 ATOM 2393 C CB . ILE A 1 305 ? 126.859 -5.350 42.180 1.00 39.32 ? 305 ILE A CB 1 ATOM 2394 C CG1 . ILE A 1 305 ? 125.437 -5.739 42.637 1.00 37.97 ? 305 ILE A CG1 1 ATOM 2395 C CG2 . ILE A 1 305 ? 127.836 -6.476 42.177 1.00 39.18 ? 305 ILE A CG2 1 ATOM 2396 C CD1 . ILE A 1 305 ? 124.974 -7.161 42.209 1.00 40.16 ? 305 ILE A CD1 1 ATOM 2397 N N . LEU A 1 306 ? 128.798 -2.971 41.389 1.00 39.52 ? 306 LEU A N 1 ATOM 2398 C CA . LEU A 1 306 ? 130.022 -2.327 40.866 1.00 39.99 ? 306 LEU A CA 1 ATOM 2399 C C . LEU A 1 306 ? 130.826 -1.443 41.901 1.00 40.28 ? 306 LEU A C 1 ATOM 2400 O O . LEU A 1 306 ? 132.062 -1.531 41.999 1.00 40.03 ? 306 LEU A O 1 ATOM 2401 C CB . LEU A 1 306 ? 129.716 -1.552 39.542 1.00 38.85 ? 306 LEU A CB 1 ATOM 2402 C CG . LEU A 1 306 ? 129.038 -2.379 38.426 1.00 38.24 ? 306 LEU A CG 1 ATOM 2403 C CD1 . LEU A 1 306 ? 128.654 -1.581 37.159 1.00 35.63 ? 306 LEU A CD1 1 ATOM 2404 C CD2 . LEU A 1 306 ? 129.898 -3.595 38.037 1.00 39.05 ? 306 LEU A CD2 1 ATOM 2405 N N . LEU A 1 307 ? 130.102 -0.591 42.644 1.00 40.63 ? 307 LEU A N 1 ATOM 2406 C CA . LEU A 1 307 ? 130.681 0.317 43.641 1.00 40.25 ? 307 LEU A CA 1 ATOM 2407 C C . LEU A 1 307 ? 131.312 -0.539 44.742 1.00 39.80 ? 307 LEU A C 1 ATOM 2408 O O . LEU A 1 307 ? 132.491 -0.387 45.074 1.00 40.29 ? 307 LEU A O 1 ATOM 2409 C CB . LEU A 1 307 ? 129.619 1.267 44.251 1.00 39.31 ? 307 LEU A CB 1 ATOM 2410 C CG . LEU A 1 307 ? 130.090 2.339 45.290 1.00 39.64 ? 307 LEU A CG 1 ATOM 2411 C CD1 . LEU A 1 307 ? 131.123 3.341 44.728 1.00 42.15 ? 307 LEU A CD1 1 ATOM 2412 C CD2 . LEU A 1 307 ? 128.909 3.139 45.924 1.00 37.47 ? 307 LEU A CD2 1 ATOM 2413 N N . GLU A 1 308 ? 130.494 -1.437 45.272 1.00 39.53 ? 308 GLU A N 1 ATOM 2414 C CA . GLU A 1 308 ? 130.878 -2.338 46.328 1.00 40.68 ? 308 GLU A CA 1 ATOM 2415 C C . GLU A 1 308 ? 132.194 -3.062 46.014 1.00 40.07 ? 308 GLU A C 1 ATOM 2416 O O . GLU A 1 308 ? 133.039 -3.190 46.880 1.00 40.80 ? 308 GLU A O 1 ATOM 2417 C CB . GLU A 1 308 ? 129.726 -3.291 46.626 1.00 40.49 ? 308 GLU A CB 1 ATOM 2418 C CG . GLU A 1 308 ? 129.947 -4.177 47.848 1.00 45.59 ? 308 GLU A CG 1 ATOM 2419 C CD . GLU A 1 308 ? 130.184 -3.402 49.132 1.00 52.68 ? 308 GLU A CD 1 ATOM 2420 O OE1 . GLU A 1 308 ? 130.947 -3.890 49.990 1.00 53.57 ? 308 GLU A OE1 1 ATOM 2421 O OE2 . GLU A 1 308 ? 129.599 -2.299 49.290 1.00 55.56 ? 308 GLU A OE2 1 ATOM 2422 N N . LEU A 1 309 ? 132.405 -3.443 44.754 1.00 38.99 ? 309 LEU A N 1 ATOM 2423 C CA . LEU A 1 309 ? 133.461 -4.383 44.419 1.00 38.08 ? 309 LEU A CA 1 ATOM 2424 C C . LEU A 1 309 ? 134.536 -3.722 43.680 1.00 38.57 ? 309 LEU A C 1 ATOM 2425 O O . LEU A 1 309 ? 135.406 -4.424 43.156 1.00 39.38 ? 309 LEU A O 1 ATOM 2426 C CB . LEU A 1 309 ? 132.939 -5.578 43.612 1.00 36.20 ? 309 LEU A CB 1 ATOM 2427 C CG . LEU A 1 309 ? 131.951 -6.431 44.411 1.00 36.87 ? 309 LEU A CG 1 ATOM 2428 C CD1 . LEU A 1 309 ? 131.435 -7.530 43.544 1.00 38.43 ? 309 LEU A CD1 1 ATOM 2429 C CD2 . LEU A 1 309 ? 132.543 -7.013 45.756 1.00 33.53 ? 309 LEU A CD2 1 ATOM 2430 N N . GLY A 1 310 ? 134.468 -2.383 43.614 1.00 38.36 ? 310 GLY A N 1 ATOM 2431 C CA . GLY A 1 310 ? 135.576 -1.525 43.158 1.00 37.39 ? 310 GLY A CA 1 ATOM 2432 C C . GLY A 1 310 ? 135.736 -1.529 41.656 1.00 39.10 ? 310 GLY A C 1 ATOM 2433 O O . GLY A 1 310 ? 136.850 -1.323 41.168 1.00 37.93 ? 310 GLY A O 1 ATOM 2434 N N . GLN A 1 311 ? 134.639 -1.768 40.917 1.00 38.16 ? 311 GLN A N 1 ATOM 2435 C CA . GLN A 1 311 ? 134.717 -1.791 39.457 1.00 38.79 ? 311 GLN A CA 1 ATOM 2436 C C . GLN A 1 311 ? 134.282 -0.452 38.899 1.00 38.63 ? 311 GLN A C 1 ATOM 2437 O O . GLN A 1 311 ? 133.111 -0.272 38.556 1.00 39.05 ? 311 GLN A O 1 ATOM 2438 C CB . GLN A 1 311 ? 133.798 -2.869 38.875 1.00 39.35 ? 311 GLN A CB 1 ATOM 2439 C CG . GLN A 1 311 ? 133.943 -4.235 39.507 1.00 42.72 ? 311 GLN A CG 1 ATOM 2440 C CD . GLN A 1 311 ? 135.385 -4.736 39.496 1.00 47.01 ? 311 GLN A CD 1 ATOM 2441 O OE1 . GLN A 1 311 ? 135.957 -5.042 40.560 1.00 47.95 ? 311 GLN A OE1 1 ATOM 2442 N NE2 . GLN A 1 311 ? 135.977 -4.817 38.299 1.00 46.38 ? 311 GLN A NE2 1 ATOM 2443 N N . PHE A 1 312 ? 135.220 0.487 38.826 1.00 37.59 ? 312 PHE A N 1 ATOM 2444 C CA . PHE A 1 312 ? 134.975 1.839 38.382 1.00 37.56 ? 312 PHE A CA 1 ATOM 2445 C C . PHE A 1 312 ? 136.312 2.503 38.147 1.00 38.22 ? 312 PHE A C 1 ATOM 2446 O O . PHE A 1 312 ? 137.391 1.989 38.565 1.00 37.94 ? 312 PHE A O 1 ATOM 2447 C CB . PHE A 1 312 ? 134.171 2.674 39.425 1.00 37.68 ? 312 PHE A CB 1 ATOM 2448 C CG . PHE A 1 312 ? 134.706 2.599 40.813 1.00 37.59 ? 312 PHE A CG 1 ATOM 2449 C CD1 . PHE A 1 312 ? 135.845 3.315 41.180 1.00 37.54 ? 312 PHE A CD1 1 ATOM 2450 C CD2 . PHE A 1 312 ? 134.067 1.846 41.767 1.00 37.16 ? 312 PHE A CD2 1 ATOM 2451 C CE1 . PHE A 1 312 ? 136.347 3.245 42.470 1.00 35.68 ? 312 PHE A CE1 1 ATOM 2452 C CE2 . PHE A 1 312 ? 134.570 1.786 43.058 1.00 35.46 ? 312 PHE A CE2 1 ATOM 2453 C CZ . PHE A 1 312 ? 135.718 2.523 43.402 1.00 32.84 ? 312 PHE A CZ 1 ATOM 2454 N N . LYS A 1 313 ? 136.231 3.662 37.512 1.00 37.43 ? 313 LYS A N 1 ATOM 2455 C CA . LYS A 1 313 ? 137.399 4.376 37.109 1.00 37.72 ? 313 LYS A CA 1 ATOM 2456 C C . LYS A 1 313 ? 138.142 4.872 38.353 1.00 37.88 ? 313 LYS A C 1 ATOM 2457 O O . LYS A 1 313 ? 137.545 5.522 39.228 1.00 38.95 ? 313 LYS A O 1 ATOM 2458 C CB . LYS A 1 313 ? 137.013 5.557 36.219 1.00 37.41 ? 313 LYS A CB 1 ATOM 2459 C CG . LYS A 1 313 ? 138.193 6.418 35.802 1.00 35.88 ? 313 LYS A CG 1 ATOM 2460 C CD . LYS A 1 313 ? 137.708 7.631 35.009 1.00 40.98 ? 313 LYS A CD 1 ATOM 2461 C CE . LYS A 1 313 ? 138.842 8.556 34.672 1.00 39.98 ? 313 LYS A CE 1 ATOM 2462 N NZ . LYS A 1 313 ? 139.714 7.851 33.668 1.00 42.93 ? 313 LYS A NZ 1 ATOM 2463 N N . LYS A 1 314 ? 139.436 4.584 38.414 1.00 37.16 ? 314 LYS A N 1 ATOM 2464 C CA . LYS A 1 314 ? 140.251 4.918 39.577 1.00 37.34 ? 314 LYS A CA 1 ATOM 2465 C C . LYS A 1 314 ? 140.821 6.324 39.407 1.00 38.09 ? 314 LYS A C 1 ATOM 2466 O O . LYS A 1 314 ? 141.706 6.548 38.579 1.00 38.97 ? 314 LYS A O 1 ATOM 2467 C CB . LYS A 1 314 ? 141.377 3.886 39.735 1.00 38.21 ? 314 LYS A CB 1 ATOM 2468 C CG . LYS A 1 314 ? 140.936 2.486 40.207 1.00 38.00 ? 314 LYS A CG 1 ATOM 2469 C CD . LYS A 1 314 ? 139.840 2.565 41.286 1.00 43.30 ? 314 LYS A CD 1 ATOM 2470 C CE . LYS A 1 314 ? 139.346 1.178 41.716 1.00 41.01 ? 314 LYS A CE 1 ATOM 2471 N NZ . LYS A 1 314 ? 138.880 0.381 40.613 1.00 37.63 ? 314 LYS A NZ 1 ATOM 2472 N N . THR A 1 315 ? 140.272 7.295 40.137 1.00 37.77 ? 315 THR A N 1 ATOM 2473 C CA . THR A 1 315 ? 140.642 8.707 39.957 1.00 36.79 ? 315 THR A CA 1 ATOM 2474 C C . THR A 1 315 ? 140.195 9.502 41.163 1.00 36.08 ? 315 THR A C 1 ATOM 2475 O O . THR A 1 315 ? 139.590 8.935 42.048 1.00 36.55 ? 315 THR A O 1 ATOM 2476 C CB . THR A 1 315 ? 140.050 9.287 38.658 1.00 36.84 ? 315 THR A CB 1 ATOM 2477 O OG1 . THR A 1 315 ? 140.578 10.596 38.500 1.00 36.76 ? 315 THR A OG1 1 ATOM 2478 C CG2 . THR A 1 315 ? 138.514 9.543 38.764 1.00 35.40 ? 315 THR A CG2 1 ATOM 2479 N N . GLN A 1 316 ? 140.499 10.793 41.224 1.00 36.19 ? 316 GLN A N 1 ATOM 2480 C CA . GLN A 1 316 ? 139.985 11.663 42.331 1.00 36.25 ? 316 GLN A CA 1 ATOM 2481 C C . GLN A 1 316 ? 138.545 12.117 42.069 1.00 36.04 ? 316 GLN A C 1 ATOM 2482 O O . GLN A 1 316 ? 138.142 12.327 40.933 1.00 35.30 ? 316 GLN A O 1 ATOM 2483 C CB . GLN A 1 316 ? 140.857 12.911 42.571 1.00 35.61 ? 316 GLN A CB 1 ATOM 2484 C CG . GLN A 1 316 ? 142.338 12.657 42.712 1.00 36.07 ? 316 GLN A CG 1 ATOM 2485 C CD . GLN A 1 316 ? 142.991 12.202 41.425 1.00 40.35 ? 316 GLN A CD 1 ATOM 2486 O OE1 . GLN A 1 316 ? 142.754 12.755 40.328 1.00 38.33 ? 316 GLN A OE1 1 ATOM 2487 N NE2 . GLN A 1 316 ? 143.772 11.148 41.539 1.00 40.24 ? 316 GLN A NE2 1 ATOM 2488 N N . ILE A 1 317 ? 137.785 12.238 43.156 1.00 35.88 ? 317 ILE A N 1 ATOM 2489 C CA . ILE A 1 317 ? 136.421 12.753 43.148 1.00 34.98 ? 317 ILE A CA 1 ATOM 2490 C C . ILE A 1 317 ? 136.262 13.897 44.172 1.00 34.84 ? 317 ILE A C 1 ATOM 2491 O O . ILE A 1 317 ? 136.942 13.914 45.215 1.00 34.35 ? 317 ILE A O 1 ATOM 2492 C CB . ILE A 1 317 ? 135.376 11.666 43.396 1.00 33.98 ? 317 ILE A CB 1 ATOM 2493 C CG1 . ILE A 1 317 ? 135.604 10.978 44.719 1.00 35.97 ? 317 ILE A CG1 1 ATOM 2494 C CG2 . ILE A 1 317 ? 135.339 10.669 42.242 1.00 35.82 ? 317 ILE A CG2 1 ATOM 2495 C CD1 . ILE A 1 317 ? 134.441 10.078 45.129 1.00 40.21 ? 317 ILE A CD1 1 ATOM 2496 N N . LEU A 1 318 ? 135.405 14.869 43.827 1.00 33.60 ? 318 LEU A N 1 ATOM 2497 C CA . LEU A 1 318 ? 134.987 15.903 44.738 1.00 33.72 ? 318 LEU A CA 1 ATOM 2498 C C . LEU A 1 318 ? 133.461 15.768 44.801 1.00 34.31 ? 318 LEU A C 1 ATOM 2499 O O . LEU A 1 318 ? 132.774 15.762 43.787 1.00 35.30 ? 318 LEU A O 1 ATOM 2500 C CB . LEU A 1 318 ? 135.449 17.264 44.218 1.00 33.46 ? 318 LEU A CB 1 ATOM 2501 C CG . LEU A 1 318 ? 135.235 18.606 44.898 1.00 32.09 ? 318 LEU A CG 1 ATOM 2502 C CD1 . LEU A 1 318 ? 136.039 19.704 44.159 1.00 30.78 ? 318 LEU A CD1 1 ATOM 2503 C CD2 . LEU A 1 318 ? 133.839 19.051 44.811 1.00 35.06 ? 318 LEU A CD2 1 ATOM 2504 N N . VAL A 1 319 ? 132.925 15.653 46.001 1.00 34.03 ? 319 VAL A N 1 ATOM 2505 C CA . VAL A 1 319 ? 131.517 15.330 46.171 1.00 32.78 ? 319 VAL A CA 1 ATOM 2506 C C . VAL A 1 319 ? 131.027 16.261 47.250 1.00 33.65 ? 319 VAL A C 1 ATOM 2507 O O . VAL A 1 319 ? 131.777 16.628 48.185 1.00 34.36 ? 319 VAL A O 1 ATOM 2508 C CB . VAL A 1 319 ? 131.333 13.861 46.636 1.00 33.08 ? 319 VAL A CB 1 ATOM 2509 C CG1 . VAL A 1 319 ? 129.881 13.440 46.603 1.00 32.12 ? 319 VAL A CG1 1 ATOM 2510 C CG2 . VAL A 1 319 ? 132.161 12.874 45.803 1.00 29.47 ? 319 VAL A CG2 1 ATOM 2511 N N . GLY A 1 320 ? 129.792 16.703 47.145 1.00 33.43 ? 320 GLY A N 1 ATOM 2512 C CA . GLY A 1 320 ? 129.272 17.544 48.206 1.00 33.12 ? 320 GLY A CA 1 ATOM 2513 C C . GLY A 1 320 ? 127.765 17.690 48.140 1.00 34.36 ? 320 GLY A C 1 ATOM 2514 O O . GLY A 1 320 ? 127.119 17.225 47.181 1.00 33.29 ? 320 GLY A O 1 ATOM 2515 N N . VAL A 1 321 ? 127.198 18.303 49.194 1.00 35.06 ? 321 VAL A N 1 ATOM 2516 C CA . VAL A 1 321 ? 125.754 18.468 49.311 1.00 35.14 ? 321 VAL A CA 1 ATOM 2517 C C . VAL A 1 321 ? 125.512 19.797 49.968 1.00 35.68 ? 321 VAL A C 1 ATOM 2518 O O . VAL A 1 321 ? 126.420 20.375 50.572 1.00 35.90 ? 321 VAL A O 1 ATOM 2519 C CB . VAL A 1 321 ? 125.098 17.348 50.176 1.00 35.81 ? 321 VAL A CB 1 ATOM 2520 C CG1 . VAL A 1 321 ? 125.227 15.985 49.476 1.00 36.56 ? 321 VAL A CG1 1 ATOM 2521 C CG2 . VAL A 1 321 ? 125.733 17.360 51.620 1.00 33.15 ? 321 VAL A CG2 1 ATOM 2522 N N . ASN A 1 322 ? 124.270 20.265 49.852 1.00 35.56 ? 322 ASN A N 1 ATOM 2523 C CA . ASN A 1 322 ? 123.797 21.464 50.490 1.00 35.60 ? 322 ASN A CA 1 ATOM 2524 C C . ASN A 1 322 ? 123.055 21.098 51.734 1.00 36.41 ? 322 ASN A C 1 ATOM 2525 O O . ASN A 1 322 ? 122.490 19.996 51.824 1.00 35.86 ? 322 ASN A O 1 ATOM 2526 C CB . ASN A 1 322 ? 122.838 22.181 49.541 1.00 35.30 ? 322 ASN A CB 1 ATOM 2527 C CG . ASN A 1 322 ? 123.513 22.565 48.265 1.00 36.98 ? 322 ASN A CG 1 ATOM 2528 O OD1 . ASN A 1 322 ? 124.720 22.286 48.080 1.00 36.21 ? 322 ASN A OD1 1 ATOM 2529 N ND2 . ASN A 1 322 ? 122.774 23.192 47.366 1.00 34.03 ? 322 ASN A ND2 1 ATOM 2530 N N . LYS A 1 323 ? 123.007 22.065 52.653 1.00 37.06 ? 323 LYS A N 1 ATOM 2531 C CA . LYS A 1 323 ? 122.415 21.930 53.997 1.00 37.65 ? 323 LYS A CA 1 ATOM 2532 C C . LYS A 1 323 ? 120.932 21.591 53.998 1.00 37.57 ? 323 LYS A C 1 ATOM 2533 O O . LYS A 1 323 ? 120.488 20.781 54.810 1.00 36.71 ? 323 LYS A O 1 ATOM 2534 C CB . LYS A 1 323 ? 122.666 23.234 54.781 1.00 38.39 ? 323 LYS A CB 1 ATOM 2535 C CG . LYS A 1 323 ? 122.231 23.282 56.220 1.00 39.85 ? 323 LYS A CG 1 ATOM 2536 C CD . LYS A 1 323 ? 122.494 24.672 56.807 1.00 43.03 ? 323 LYS A CD 1 ATOM 2537 C CE . LYS A 1 323 ? 121.850 24.817 58.269 1.00 51.94 ? 323 LYS A CE 1 ATOM 2538 N NZ . LYS A 1 323 ? 121.532 26.292 58.706 1.00 54.18 ? 323 LYS A NZ 1 ATOM 2539 N N . ASP A 1 324 ? 120.169 22.192 53.085 1.00 37.10 ? 324 ASP A N 1 ATOM 2540 C CA . ASP A 1 324 ? 118.729 21.947 53.043 1.00 37.64 ? 324 ASP A CA 1 ATOM 2541 C C . ASP A 1 324 ? 118.260 21.360 51.697 1.00 37.83 ? 324 ASP A C 1 ATOM 2542 O O . ASP A 1 324 ? 117.296 21.851 51.078 1.00 37.76 ? 324 ASP A O 1 ATOM 2543 C CB . ASP A 1 324 ? 117.938 23.216 53.418 1.00 37.63 ? 324 ASP A CB 1 ATOM 2544 C CG . ASP A 1 324 ? 118.351 23.794 54.791 1.00 39.95 ? 324 ASP A CG 1 ATOM 2545 O OD1 . ASP A 1 324 ? 118.118 23.159 55.849 1.00 40.30 ? 324 ASP A OD1 1 ATOM 2546 O OD2 . ASP A 1 324 ? 118.887 24.910 54.914 1.00 41.51 ? 324 ASP A OD2 1 ATOM 2547 N N . GLU A 1 325 ? 118.930 20.288 51.280 1.00 37.64 ? 325 GLU A N 1 ATOM 2548 C CA . GLU A 1 325 ? 118.551 19.525 50.078 1.00 38.05 ? 325 GLU A CA 1 ATOM 2549 C C . GLU A 1 325 ? 117.035 19.233 49.924 1.00 38.74 ? 325 GLU A C 1 ATOM 2550 O O . GLU A 1 325 ? 116.459 19.396 48.824 1.00 40.24 ? 325 GLU A O 1 ATOM 2551 C CB . GLU A 1 325 ? 119.286 18.188 50.079 1.00 36.69 ? 325 GLU A CB 1 ATOM 2552 C CG . GLU A 1 325 ? 120.794 18.325 49.881 1.00 37.33 ? 325 GLU A CG 1 ATOM 2553 C CD . GLU A 1 325 ? 121.143 18.719 48.451 1.00 36.99 ? 325 GLU A CD 1 ATOM 2554 O OE1 . GLU A 1 325 ? 120.209 18.871 47.619 1.00 36.37 ? 325 GLU A OE1 1 ATOM 2555 O OE2 . GLU A 1 325 ? 122.352 18.866 48.170 1.00 35.13 ? 325 GLU A OE2 1 ATOM 2556 N N . GLY A 1 326 ? 116.398 18.774 50.997 1.00 38.17 ? 326 GLY A N 1 ATOM 2557 C CA . GLY A 1 326 ? 115.035 18.308 50.874 1.00 38.20 ? 326 GLY A CA 1 ATOM 2558 C C . GLY A 1 326 ? 113.927 19.360 50.789 1.00 39.01 ? 326 GLY A C 1 ATOM 2559 O O . GLY A 1 326 ? 112.843 19.013 50.347 1.00 39.69 ? 326 GLY A O 1 ATOM 2560 N N . THR A 1 327 ? 114.161 20.601 51.245 1.00 38.76 ? 327 THR A N 1 ATOM 2561 C CA . THR A 1 327 ? 113.062 21.598 51.386 1.00 40.48 ? 327 THR A CA 1 ATOM 2562 C C . THR A 1 327 ? 112.259 21.951 50.104 1.00 40.81 ? 327 THR A C 1 ATOM 2563 O O . THR A 1 327 ? 111.036 22.063 50.132 1.00 41.26 ? 327 THR A O 1 ATOM 2564 C CB . THR A 1 327 ? 113.556 22.865 52.032 1.00 40.30 ? 327 THR A CB 1 ATOM 2565 O OG1 . THR A 1 327 ? 114.686 23.371 51.299 1.00 40.23 ? 327 THR A OG1 1 ATOM 2566 C CG2 . THR A 1 327 ? 114.062 22.576 53.455 1.00 39.50 ? 327 THR A CG2 1 ATOM 2567 N N . ALA A 1 328 ? 112.986 22.129 49.009 1.00 41.68 ? 328 ALA A N 1 ATOM 2568 C CA . ALA A 1 328 ? 112.503 22.412 47.672 1.00 40.99 ? 328 ALA A CA 1 ATOM 2569 C C . ALA A 1 328 ? 111.339 21.509 47.306 1.00 41.69 ? 328 ALA A C 1 ATOM 2570 O O . ALA A 1 328 ? 110.395 21.949 46.660 1.00 41.06 ? 328 ALA A O 1 ATOM 2571 C CB . ALA A 1 328 ? 113.655 22.144 46.685 1.00 40.44 ? 328 ALA A CB 1 ATOM 2572 N N . PHE A 1 329 ? 111.430 20.226 47.679 1.00 40.84 ? 329 PHE A N 1 ATOM 2573 C CA . PHE A 1 329 ? 110.454 19.263 47.187 1.00 40.41 ? 329 PHE A CA 1 ATOM 2574 C C . PHE A 1 329 ? 109.159 19.295 47.964 1.00 40.66 ? 329 PHE A C 1 ATOM 2575 O O . PHE A 1 329 ? 108.157 18.790 47.474 1.00 39.61 ? 329 PHE A O 1 ATOM 2576 C CB . PHE A 1 329 ? 111.026 17.837 47.079 1.00 39.06 ? 329 PHE A CB 1 ATOM 2577 C CG . PHE A 1 329 ? 112.264 17.763 46.246 1.00 38.65 ? 329 PHE A CG 1 ATOM 2578 C CD1 . PHE A 1 329 ? 113.534 18.051 46.807 1.00 39.18 ? 329 PHE A CD1 1 ATOM 2579 C CD2 . PHE A 1 329 ? 112.182 17.432 44.909 1.00 39.27 ? 329 PHE A CD2 1 ATOM 2580 C CE1 . PHE A 1 329 ? 114.712 18.023 46.030 1.00 34.08 ? 329 PHE A CE1 1 ATOM 2581 C CE2 . PHE A 1 329 ? 113.335 17.366 44.151 1.00 39.15 ? 329 PHE A CE2 1 ATOM 2582 C CZ . PHE A 1 329 ? 114.607 17.660 44.728 1.00 37.83 ? 329 PHE A CZ 1 ATOM 2583 N N . LEU A 1 330 ? 109.196 19.879 49.161 1.00 41.86 ? 330 LEU A N 1 ATOM 2584 C CA . LEU A 1 330 ? 108.029 19.913 50.067 1.00 44.56 ? 330 LEU A CA 1 ATOM 2585 C C . LEU A 1 330 ? 106.814 20.695 49.536 1.00 45.76 ? 330 LEU A C 1 ATOM 2586 O O . LEU A 1 330 ? 105.681 20.357 49.874 1.00 46.40 ? 330 LEU A O 1 ATOM 2587 C CB . LEU A 1 330 ? 108.416 20.432 51.477 1.00 44.14 ? 330 LEU A CB 1 ATOM 2588 C CG . LEU A 1 330 ? 109.512 19.641 52.218 1.00 44.69 ? 330 LEU A CG 1 ATOM 2589 C CD1 . LEU A 1 330 ? 109.750 20.156 53.639 1.00 43.22 ? 330 LEU A CD1 1 ATOM 2590 C CD2 . LEU A 1 330 ? 109.204 18.126 52.205 1.00 43.00 ? 330 LEU A CD2 1 ATOM 2591 N N . VAL A 1 331 ? 107.051 21.734 48.734 1.00 45.96 ? 331 VAL A N 1 ATOM 2592 C CA . VAL A 1 331 ? 105.949 22.576 48.246 1.00 46.53 ? 331 VAL A CA 1 ATOM 2593 C C . VAL A 1 331 ? 105.345 22.049 46.911 1.00 47.23 ? 331 VAL A C 1 ATOM 2594 O O . VAL A 1 331 ? 104.481 22.706 46.296 1.00 47.11 ? 331 VAL A O 1 ATOM 2595 C CB . VAL A 1 331 ? 106.371 24.065 48.191 1.00 46.51 ? 331 VAL A CB 1 ATOM 2596 C CG1 . VAL A 1 331 ? 106.634 24.572 49.625 1.00 46.48 ? 331 VAL A CG1 1 ATOM 2597 C CG2 . VAL A 1 331 ? 107.643 24.276 47.283 1.00 45.27 ? 331 VAL A CG2 1 ATOM 2598 N N . TYR A 1 332 ? 105.802 20.856 46.502 1.00 46.17 ? 332 TYR A N 1 ATOM 2599 C CA . TYR A 1 332 ? 105.276 20.145 45.369 1.00 46.05 ? 332 TYR A CA 1 ATOM 2600 C C . TYR A 1 332 ? 104.419 18.942 45.796 1.00 48.14 ? 332 TYR A C 1 ATOM 2601 O O . TYR A 1 332 ? 104.333 17.929 45.067 1.00 48.02 ? 332 TYR A O 1 ATOM 2602 C CB . TYR A 1 332 ? 106.408 19.682 44.441 1.00 44.88 ? 332 TYR A CB 1 ATOM 2603 C CG . TYR A 1 332 ? 107.103 20.823 43.770 1.00 43.71 ? 332 TYR A CG 1 ATOM 2604 C CD1 . TYR A 1 332 ? 108.078 21.582 44.457 1.00 41.65 ? 332 TYR A CD1 1 ATOM 2605 C CD2 . TYR A 1 332 ? 106.776 21.179 42.450 1.00 44.10 ? 332 TYR A CD2 1 ATOM 2606 C CE1 . TYR A 1 332 ? 108.708 22.655 43.853 1.00 41.20 ? 332 TYR A CE1 1 ATOM 2607 C CE2 . TYR A 1 332 ? 107.393 22.258 41.825 1.00 42.28 ? 332 TYR A CE2 1 ATOM 2608 C CZ . TYR A 1 332 ? 108.354 22.979 42.539 1.00 41.86 ? 332 TYR A CZ 1 ATOM 2609 O OH . TYR A 1 332 ? 108.959 24.006 41.931 1.00 42.34 ? 332 TYR A OH 1 ATOM 2610 N N . GLY A 1 333 ? 103.800 19.025 46.976 1.00 49.47 ? 333 GLY A N 1 ATOM 2611 C CA . GLY A 1 333 ? 102.824 18.015 47.326 1.00 51.40 ? 333 GLY A CA 1 ATOM 2612 C C . GLY A 1 333 ? 102.601 17.714 48.793 1.00 52.66 ? 333 GLY A C 1 ATOM 2613 O O . GLY A 1 333 ? 101.601 17.095 49.118 1.00 53.40 ? 333 GLY A O 1 ATOM 2614 N N . ALA A 1 334 ? 103.515 18.118 49.680 1.00 52.99 ? 334 ALA A N 1 ATOM 2615 C CA . ALA A 1 334 ? 103.343 17.838 51.115 1.00 52.89 ? 334 ALA A CA 1 ATOM 2616 C C . ALA A 1 334 ? 102.260 18.721 51.753 1.00 53.24 ? 334 ALA A C 1 ATOM 2617 O O . ALA A 1 334 ? 102.336 19.971 51.684 1.00 53.83 ? 334 ALA A O 1 ATOM 2618 C CB . ALA A 1 334 ? 104.676 17.977 51.873 1.00 52.65 ? 334 ALA A CB 1 ATOM 2619 N N . PRO A 1 335 ? 101.266 18.096 52.402 1.00 53.32 ? 335 PRO A N 1 ATOM 2620 C CA . PRO A 1 335 ? 100.150 18.852 52.985 1.00 52.62 ? 335 PRO A CA 1 ATOM 2621 C C . PRO A 1 335 ? 100.645 19.889 54.000 1.00 52.18 ? 335 PRO A C 1 ATOM 2622 O O . PRO A 1 335 ? 101.535 19.583 54.790 1.00 52.76 ? 335 PRO A O 1 ATOM 2623 C CB . PRO A 1 335 ? 99.333 17.764 53.669 1.00 53.13 ? 335 PRO A CB 1 ATOM 2624 C CG . PRO A 1 335 ? 99.652 16.528 52.881 1.00 53.50 ? 335 PRO A CG 1 ATOM 2625 C CD . PRO A 1 335 ? 101.131 16.642 52.633 1.00 53.13 ? 335 PRO A CD 1 ATOM 2626 N N . GLY A 1 336 ? 100.118 21.113 53.945 1.00 51.53 ? 336 GLY A N 1 ATOM 2627 C CA . GLY A 1 336 ? 100.450 22.179 54.904 1.00 50.62 ? 336 GLY A CA 1 ATOM 2628 C C . GLY A 1 336 ? 101.653 23.028 54.524 1.00 50.84 ? 336 GLY A C 1 ATOM 2629 O O . GLY A 1 336 ? 101.968 24.004 55.216 1.00 50.71 ? 336 GLY A O 1 ATOM 2630 N N . PHE A 1 337 ? 102.319 22.681 53.419 1.00 50.28 ? 337 PHE A N 1 ATOM 2631 C CA . PHE A 1 337 ? 103.514 23.435 53.001 1.00 50.55 ? 337 PHE A CA 1 ATOM 2632 C C . PHE A 1 337 ? 103.167 24.528 51.989 1.00 50.85 ? 337 PHE A C 1 ATOM 2633 O O . PHE A 1 337 ? 102.272 24.345 51.155 1.00 50.70 ? 337 PHE A O 1 ATOM 2634 C CB . PHE A 1 337 ? 104.628 22.509 52.468 1.00 49.43 ? 337 PHE A CB 1 ATOM 2635 C CG . PHE A 1 337 ? 105.355 21.786 53.558 1.00 48.40 ? 337 PHE A CG 1 ATOM 2636 C CD1 . PHE A 1 337 ? 104.903 20.546 54.006 1.00 44.77 ? 337 PHE A CD1 1 ATOM 2637 C CD2 . PHE A 1 337 ? 106.451 22.372 54.180 1.00 48.44 ? 337 PHE A CD2 1 ATOM 2638 C CE1 . PHE A 1 337 ? 105.552 19.876 55.043 1.00 47.55 ? 337 PHE A CE1 1 ATOM 2639 C CE2 . PHE A 1 337 ? 107.100 21.707 55.230 1.00 51.24 ? 337 PHE A CE2 1 ATOM 2640 C CZ . PHE A 1 337 ? 106.645 20.441 55.645 1.00 47.42 ? 337 PHE A CZ 1 ATOM 2641 N N . SER A 1 338 ? 103.850 25.662 52.081 1.00 50.08 ? 338 SER A N 1 ATOM 2642 C CA . SER A 1 338 ? 103.669 26.672 51.046 1.00 50.40 ? 338 SER A CA 1 ATOM 2643 C C . SER A 1 338 ? 104.888 27.534 51.008 1.00 49.35 ? 338 SER A C 1 ATOM 2644 O O . SER A 1 338 ? 105.459 27.806 52.052 1.00 49.04 ? 338 SER A O 1 ATOM 2645 C CB . SER A 1 338 ? 102.385 27.486 51.322 1.00 50.63 ? 338 SER A CB 1 ATOM 2646 O OG . SER A 1 338 ? 102.491 28.823 50.867 1.00 52.24 ? 338 SER A OG 1 ATOM 2647 N N . LYS A 1 339 ? 105.326 27.954 49.822 1.00 49.81 ? 339 LYS A N 1 ATOM 2648 C CA . LYS A 1 339 ? 106.440 28.914 49.776 1.00 50.56 ? 339 LYS A CA 1 ATOM 2649 C C . LYS A 1 339 ? 105.969 30.274 50.318 1.00 51.30 ? 339 LYS A C 1 ATOM 2650 O O . LYS A 1 339 ? 106.776 31.120 50.747 1.00 52.11 ? 339 LYS A O 1 ATOM 2651 C CB . LYS A 1 339 ? 107.015 29.053 48.372 1.00 50.66 ? 339 LYS A CB 1 ATOM 2652 C CG . LYS A 1 339 ? 106.039 29.666 47.352 1.00 51.65 ? 339 LYS A CG 1 ATOM 2653 C CD . LYS A 1 339 ? 106.705 29.979 46.003 1.00 51.19 ? 339 LYS A CD 1 ATOM 2654 C CE . LYS A 1 339 ? 105.843 30.957 45.200 1.00 51.93 ? 339 LYS A CE 1 ATOM 2655 N NZ . LYS A 1 339 ? 105.759 32.316 45.905 1.00 54.28 ? 339 LYS A NZ 1 ATOM 2656 N N . ASP A 1 340 ? 104.651 30.457 50.328 1.00 51.86 ? 340 ASP A N 1 ATOM 2657 C CA . ASP A 1 340 ? 104.040 31.742 50.646 1.00 52.90 ? 340 ASP A CA 1 ATOM 2658 C C . ASP A 1 340 ? 103.676 31.919 52.113 1.00 53.43 ? 340 ASP A C 1 ATOM 2659 O O . ASP A 1 340 ? 103.078 32.938 52.488 1.00 53.04 ? 340 ASP A O 1 ATOM 2660 C CB . ASP A 1 340 ? 102.822 31.965 49.739 1.00 52.40 ? 340 ASP A CB 1 ATOM 2661 C CG . ASP A 1 340 ? 103.234 32.200 48.294 1.00 52.81 ? 340 ASP A CG 1 ATOM 2662 O OD1 . ASP A 1 340 ? 102.725 31.501 47.384 1.00 52.26 ? 340 ASP A OD1 1 ATOM 2663 O OD2 . ASP A 1 340 ? 104.121 33.022 47.993 1.00 49.91 ? 340 ASP A OD2 1 ATOM 2664 N N . ASN A 1 341 ? 104.036 30.928 52.925 1.00 54.07 ? 341 ASN A N 1 ATOM 2665 C CA . ASN A 1 341 ? 103.907 30.988 54.399 1.00 55.46 ? 341 ASN A CA 1 ATOM 2666 C C . ASN A 1 341 ? 104.935 30.063 55.069 1.00 56.46 ? 341 ASN A C 1 ATOM 2667 O O . ASN A 1 341 ? 105.608 29.262 54.378 1.00 56.81 ? 341 ASN A O 1 ATOM 2668 C CB . ASN A 1 341 ? 102.462 30.693 54.894 1.00 54.89 ? 341 ASN A CB 1 ATOM 2669 C CG . ASN A 1 341 ? 102.029 29.239 54.685 1.00 55.94 ? 341 ASN A CG 1 ATOM 2670 O OD1 . ASN A 1 341 ? 102.868 28.310 54.707 1.00 56.01 ? 341 ASN A OD1 1 ATOM 2671 N ND2 . ASN A 1 341 ? 100.707 29.039 54.501 1.00 52.31 ? 341 ASN A ND2 1 ATOM 2672 N N . ASN A 1 342 ? 105.046 30.176 56.393 1.00 56.33 ? 342 ASN A N 1 ATOM 2673 C CA . ASN A 1 342 ? 106.113 29.529 57.140 1.00 57.11 ? 342 ASN A CA 1 ATOM 2674 C C . ASN A 1 342 ? 105.960 27.994 57.350 1.00 56.31 ? 342 ASN A C 1 ATOM 2675 O O . ASN A 1 342 ? 106.843 27.351 57.868 1.00 56.26 ? 342 ASN A O 1 ATOM 2676 C CB . ASN A 1 342 ? 106.399 30.303 58.450 1.00 57.82 ? 342 ASN A CB 1 ATOM 2677 C CG . ASN A 1 342 ? 105.352 30.056 59.537 1.00 60.19 ? 342 ASN A CG 1 ATOM 2678 O OD1 . ASN A 1 342 ? 104.238 29.558 59.276 1.00 61.31 ? 342 ASN A OD1 1 ATOM 2679 N ND2 . ASN A 1 342 ? 105.712 30.410 60.782 1.00 62.39 ? 342 ASN A ND2 1 ATOM 2680 N N . SER A 1 343 ? 104.823 27.445 56.942 1.00 56.11 ? 343 SER A N 1 ATOM 2681 C CA . SER A 1 343 ? 104.635 26.024 56.766 1.00 55.87 ? 343 SER A CA 1 ATOM 2682 C C . SER A 1 343 ? 104.788 25.240 58.081 1.00 56.35 ? 343 SER A C 1 ATOM 2683 O O . SER A 1 343 ? 105.196 24.059 58.063 1.00 56.14 ? 343 SER A O 1 ATOM 2684 C CB . SER A 1 343 ? 105.582 25.501 55.673 1.00 55.44 ? 343 SER A CB 1 ATOM 2685 O OG . SER A 1 343 ? 105.248 26.039 54.406 1.00 53.43 ? 343 SER A OG 1 ATOM 2686 N N . ILE A 1 344 ? 104.457 25.889 59.205 1.00 55.59 ? 344 ILE A N 1 ATOM 2687 C CA . ILE A 1 344 ? 104.370 25.202 60.498 1.00 55.95 ? 344 ILE A CA 1 ATOM 2688 C C . ILE A 1 344 ? 103.368 24.069 60.334 1.00 55.06 ? 344 ILE A C 1 ATOM 2689 O O . ILE A 1 344 ? 102.206 24.331 60.059 1.00 55.64 ? 344 ILE A O 1 ATOM 2690 C CB . ILE A 1 344 ? 103.914 26.168 61.644 1.00 56.20 ? 344 ILE A CB 1 ATOM 2691 C CG1 . ILE A 1 344 ? 104.925 27.310 61.862 1.00 57.03 ? 344 ILE A CG1 1 ATOM 2692 C CG2 . ILE A 1 344 ? 103.674 25.386 62.951 1.00 56.05 ? 344 ILE A CG2 1 ATOM 2693 C CD1 . ILE A 1 344 ? 106.265 26.890 62.530 1.00 55.55 ? 344 ILE A CD1 1 ATOM 2694 N N . ILE A 1 345 ? 103.810 22.817 60.428 1.00 54.77 ? 345 ILE A N 1 ATOM 2695 C CA . ILE A 1 345 ? 102.889 21.695 60.185 1.00 53.69 ? 345 ILE A CA 1 ATOM 2696 C C . ILE A 1 345 ? 102.742 20.875 61.458 1.00 54.54 ? 345 ILE A C 1 ATOM 2697 O O . ILE A 1 345 ? 103.569 21.003 62.388 1.00 53.45 ? 345 ILE A O 1 ATOM 2698 C CB . ILE A 1 345 ? 103.310 20.814 58.967 1.00 53.63 ? 345 ILE A CB 1 ATOM 2699 C CG1 . ILE A 1 345 ? 104.654 20.097 59.201 1.00 53.79 ? 345 ILE A CG1 1 ATOM 2700 C CG2 . ILE A 1 345 ? 103.354 21.631 57.698 1.00 52.83 ? 345 ILE A CG2 1 ATOM 2701 C CD1 . ILE A 1 345 ? 104.834 18.853 58.356 1.00 51.05 ? 345 ILE A CD1 1 ATOM 2702 N N . THR A 1 346 ? 101.684 20.056 61.495 1.00 54.47 ? 346 THR A N 1 ATOM 2703 C CA . THR A 1 346 ? 101.379 19.201 62.645 1.00 54.86 ? 346 THR A CA 1 ATOM 2704 C C . THR A 1 346 ? 101.920 17.776 62.451 1.00 55.01 ? 346 THR A C 1 ATOM 2705 O O . THR A 1 346 ? 102.296 17.380 61.343 1.00 54.51 ? 346 THR A O 1 ATOM 2706 C CB . THR A 1 346 ? 99.843 19.111 62.885 1.00 54.46 ? 346 THR A CB 1 ATOM 2707 O OG1 . THR A 1 346 ? 99.213 18.557 61.725 1.00 55.00 ? 346 THR A OG1 1 ATOM 2708 C CG2 . THR A 1 346 ? 99.230 20.464 63.018 1.00 53.83 ? 346 THR A CG2 1 ATOM 2709 N N . ARG A 1 347 ? 101.928 17.005 63.539 1.00 55.35 ? 347 ARG A N 1 ATOM 2710 C CA . ARG A 1 347 ? 102.334 15.612 63.494 1.00 55.27 ? 347 ARG A CA 1 ATOM 2711 C C . ARG A 1 347 ? 101.575 14.871 62.392 1.00 54.94 ? 347 ARG A C 1 ATOM 2712 O O . ARG A 1 347 ? 102.167 14.107 61.615 1.00 55.32 ? 347 ARG A O 1 ATOM 2713 C CB . ARG A 1 347 ? 102.102 14.971 64.859 1.00 55.68 ? 347 ARG A CB 1 ATOM 2714 C CG . ARG A 1 347 ? 102.409 13.475 64.967 1.00 57.30 ? 347 ARG A CG 1 ATOM 2715 C CD . ARG A 1 347 ? 102.340 12.982 66.403 1.00 60.59 ? 347 ARG A CD 1 ATOM 2716 N NE . ARG A 1 347 ? 102.707 11.575 66.558 1.00 65.14 ? 347 ARG A NE 1 ATOM 2717 C CZ . ARG A 1 347 ? 103.951 11.113 66.770 1.00 65.93 ? 347 ARG A CZ 1 ATOM 2718 N NH1 . ARG A 1 347 ? 104.122 9.806 66.910 1.00 66.08 ? 347 ARG A NH1 1 ATOM 2719 N NH2 . ARG A 1 347 ? 105.015 11.930 66.829 1.00 65.46 ? 347 ARG A NH2 1 ATOM 2720 N N . LYS A 1 348 ? 100.270 15.115 62.303 1.00 54.47 ? 348 LYS A N 1 ATOM 2721 C CA . LYS A 1 348 ? 99.436 14.406 61.350 1.00 53.64 ? 348 LYS A CA 1 ATOM 2722 C C . LYS A 1 348 ? 99.762 14.810 59.892 1.00 53.16 ? 348 LYS A C 1 ATOM 2723 O O . LYS A 1 348 ? 99.723 13.957 58.975 1.00 52.82 ? 348 LYS A O 1 ATOM 2724 C CB . LYS A 1 348 ? 97.935 14.543 61.723 1.00 53.96 ? 348 LYS A CB 1 ATOM 2725 C CG . LYS A 1 348 ? 97.097 13.234 61.534 1.00 54.48 ? 348 LYS A CG 1 ATOM 2726 C CD . LYS A 1 348 ? 97.570 12.072 62.468 0.50 52.72 ? 348 LYS A CD 1 ATOM 2727 C CE . LYS A 1 348 ? 97.664 10.724 61.745 0.50 52.20 ? 348 LYS A CE 1 ATOM 2728 N NZ . LYS A 1 348 ? 96.565 9.754 62.029 0.50 51.71 ? 348 LYS A NZ 1 ATOM 2729 N N . GLU A 1 349 ? 100.105 16.093 59.702 1.00 52.55 ? 349 GLU A N 1 ATOM 2730 C CA . GLU A 1 349 ? 100.667 16.615 58.429 1.00 52.49 ? 349 GLU A CA 1 ATOM 2731 C C . GLU A 1 349 ? 101.995 15.927 58.053 1.00 51.88 ? 349 GLU A C 1 ATOM 2732 O O . GLU A 1 349 ? 102.152 15.369 56.911 1.00 52.01 ? 349 GLU A O 1 ATOM 2733 C CB . GLU A 1 349 ? 100.762 18.164 58.456 1.00 52.39 ? 349 GLU A CB 1 ATOM 2734 C CG . GLU A 1 349 ? 99.398 18.839 58.158 1.00 56.25 ? 349 GLU A CG 1 ATOM 2735 C CD . GLU A 1 349 ? 99.269 20.323 58.528 1.00 55.59 ? 349 GLU A CD 1 ATOM 2736 O OE1 . GLU A 1 349 ? 98.479 21.028 57.878 1.00 59.14 ? 349 GLU A OE1 1 ATOM 2737 O OE2 . GLU A 1 349 ? 99.903 20.808 59.469 1.00 59.01 ? 349 GLU A OE2 1 ATOM 2738 N N . PHE A 1 350 ? 102.933 15.930 59.008 1.00 51.05 ? 350 PHE A N 1 ATOM 2739 C CA . PHE A 1 350 ? 104.187 15.175 58.876 1.00 50.30 ? 350 PHE A CA 1 ATOM 2740 C C . PHE A 1 350 ? 103.879 13.764 58.403 1.00 50.73 ? 350 PHE A C 1 ATOM 2741 O O . PHE A 1 350 ? 104.402 13.321 57.352 1.00 49.68 ? 350 PHE A O 1 ATOM 2742 C CB . PHE A 1 350 ? 104.942 15.176 60.196 1.00 50.47 ? 350 PHE A CB 1 ATOM 2743 C CG . PHE A 1 350 ? 106.250 14.398 60.175 1.00 50.82 ? 350 PHE A CG 1 ATOM 2744 C CD1 . PHE A 1 350 ? 107.459 15.053 59.899 1.00 50.53 ? 350 PHE A CD1 1 ATOM 2745 C CD2 . PHE A 1 350 ? 106.285 13.009 60.482 1.00 47.20 ? 350 PHE A CD2 1 ATOM 2746 C CE1 . PHE A 1 350 ? 108.707 14.326 59.909 1.00 51.01 ? 350 PHE A CE1 1 ATOM 2747 C CE2 . PHE A 1 350 ? 107.514 12.295 60.472 1.00 50.39 ? 350 PHE A CE2 1 ATOM 2748 C CZ . PHE A 1 350 ? 108.726 12.955 60.183 1.00 46.63 ? 350 PHE A CZ 1 ATOM 2749 N N . GLN A 1 351 ? 103.001 13.066 59.143 1.00 50.69 ? 351 GLN A N 1 ATOM 2750 C CA . GLN A 1 351 ? 102.662 11.683 58.797 1.00 51.73 ? 351 GLN A CA 1 ATOM 2751 C C . GLN A 1 351 ? 102.099 11.523 57.364 1.00 51.46 ? 351 GLN A C 1 ATOM 2752 O O . GLN A 1 351 ? 102.461 10.598 56.603 1.00 50.25 ? 351 GLN A O 1 ATOM 2753 C CB . GLN A 1 351 ? 101.732 11.079 59.860 1.00 52.70 ? 351 GLN A CB 1 ATOM 2754 C CG . GLN A 1 351 ? 102.388 10.899 61.273 1.00 55.48 ? 351 GLN A CG 1 ATOM 2755 C CD . GLN A 1 351 ? 101.384 10.433 62.341 1.00 59.21 ? 351 GLN A CD 1 ATOM 2756 O OE1 . GLN A 1 351 ? 100.377 11.120 62.611 1.00 58.54 ? 351 GLN A OE1 1 ATOM 2757 N NE2 . GLN A 1 351 ? 101.661 9.278 62.952 1.00 58.23 ? 351 GLN A NE2 1 ATOM 2758 N N . GLU A 1 352 ? 101.210 12.443 56.993 1.00 52.04 ? 352 GLU A N 1 ATOM 2759 C CA . GLU A 1 352 ? 100.656 12.483 55.626 1.00 52.21 ? 352 GLU A CA 1 ATOM 2760 C C . GLU A 1 352 ? 101.759 12.760 54.579 1.00 50.07 ? 352 GLU A C 1 ATOM 2761 O O . GLU A 1 352 ? 101.796 12.142 53.511 1.00 50.29 ? 352 GLU A O 1 ATOM 2762 C CB . GLU A 1 352 ? 99.502 13.527 55.562 1.00 54.33 ? 352 GLU A CB 1 ATOM 2763 C CG . GLU A 1 352 ? 98.237 13.140 56.347 1.00 58.36 ? 352 GLU A CG 1 ATOM 2764 C CD . GLU A 1 352 ? 97.630 11.810 55.875 1.00 66.35 ? 352 GLU A CD 1 ATOM 2765 O OE1 . GLU A 1 352 ? 97.544 11.582 54.643 1.00 70.49 ? 352 GLU A OE1 1 ATOM 2766 O OE2 . GLU A 1 352 ? 97.237 10.969 56.722 1.00 70.04 ? 352 GLU A OE2 1 ATOM 2767 N N . GLY A 1 353 ? 102.681 13.654 54.913 1.00 48.52 ? 353 GLY A N 1 ATOM 2768 C CA . GLY A 1 353 ? 103.864 13.920 54.062 1.00 47.04 ? 353 GLY A CA 1 ATOM 2769 C C . GLY A 1 353 ? 104.723 12.726 53.727 1.00 45.96 ? 353 GLY A C 1 ATOM 2770 O O . GLY A 1 353 ? 105.183 12.587 52.598 1.00 46.17 ? 353 GLY A O 1 ATOM 2771 N N . LEU A 1 354 ? 104.916 11.833 54.696 1.00 45.47 ? 354 LEU A N 1 ATOM 2772 C CA . LEU A 1 354 ? 105.632 10.582 54.464 1.00 45.46 ? 354 LEU A CA 1 ATOM 2773 C C . LEU A 1 354 ? 104.935 9.730 53.433 1.00 46.00 ? 354 LEU A C 1 ATOM 2774 O O . LEU A 1 354 ? 105.571 9.080 52.591 1.00 45.57 ? 354 LEU A O 1 ATOM 2775 C CB . LEU A 1 354 ? 105.768 9.770 55.744 1.00 44.71 ? 354 LEU A CB 1 ATOM 2776 C CG . LEU A 1 354 ? 106.756 10.220 56.797 1.00 45.46 ? 354 LEU A CG 1 ATOM 2777 C CD1 . LEU A 1 354 ? 107.102 9.015 57.566 1.00 46.94 ? 354 LEU A CD1 1 ATOM 2778 C CD2 . LEU A 1 354 ? 108.049 10.837 56.226 1.00 46.49 ? 354 LEU A CD2 1 ATOM 2779 N N . LYS A 1 355 ? 103.612 9.732 53.518 1.00 46.32 ? 355 LYS A N 1 ATOM 2780 C CA . LYS A 1 355 ? 102.799 9.017 52.582 1.00 46.96 ? 355 LYS A CA 1 ATOM 2781 C C . LYS A 1 355 ? 103.054 9.578 51.170 1.00 46.95 ? 355 LYS A C 1 ATOM 2782 O O . LYS A 1 355 ? 103.153 8.806 50.232 1.00 47.82 ? 355 LYS A O 1 ATOM 2783 C CB . LYS A 1 355 ? 101.329 9.125 52.995 1.00 47.29 ? 355 LYS A CB 1 ATOM 2784 C CG . LYS A 1 355 ? 100.796 7.920 53.627 1.00 50.02 ? 355 LYS A CG 1 ATOM 2785 C CD . LYS A 1 355 ? 99.419 7.540 52.971 1.00 53.80 ? 355 LYS A CD 1 ATOM 2786 C CE . LYS A 1 355 ? 98.224 7.978 53.830 1.00 56.12 ? 355 LYS A CE 1 ATOM 2787 N NZ . LYS A 1 355 ? 96.876 7.461 53.372 1.00 54.30 ? 355 LYS A NZ 1 ATOM 2788 N N . ILE A 1 356 ? 103.180 10.907 51.037 1.00 47.72 ? 356 ILE A N 1 ATOM 2789 C CA . ILE A 1 356 ? 103.551 11.547 49.765 1.00 48.50 ? 356 ILE A CA 1 ATOM 2790 C C . ILE A 1 356 ? 104.929 11.066 49.296 1.00 48.25 ? 356 ILE A C 1 ATOM 2791 O O . ILE A 1 356 ? 105.078 10.528 48.216 1.00 48.47 ? 356 ILE A O 1 ATOM 2792 C CB . ILE A 1 356 ? 103.566 13.117 49.872 1.00 49.24 ? 356 ILE A CB 1 ATOM 2793 C CG1 . ILE A 1 356 ? 102.263 13.701 50.488 1.00 50.71 ? 356 ILE A CG1 1 ATOM 2794 C CG2 . ILE A 1 356 ? 103.895 13.770 48.492 1.00 50.55 ? 356 ILE A CG2 1 ATOM 2795 C CD1 . ILE A 1 356 ? 100.978 13.405 49.745 1.00 50.24 ? 356 ILE A CD1 1 ATOM 2796 N N . PHE A 1 357 ? 105.947 11.233 50.129 1.00 48.35 ? 357 PHE A N 1 ATOM 2797 C CA . PHE A 1 357 ? 107.287 10.870 49.726 1.00 47.30 ? 357 PHE A CA 1 ATOM 2798 C C . PHE A 1 357 ? 107.672 9.390 49.778 1.00 47.70 ? 357 PHE A C 1 ATOM 2799 O O . PHE A 1 357 ? 108.678 8.993 49.190 1.00 47.96 ? 357 PHE A O 1 ATOM 2800 C CB . PHE A 1 357 ? 108.254 11.703 50.536 1.00 47.51 ? 357 PHE A CB 1 ATOM 2801 C CG . PHE A 1 357 ? 108.250 13.132 50.155 1.00 46.67 ? 357 PHE A CG 1 ATOM 2802 C CD1 . PHE A 1 357 ? 108.958 13.558 49.026 1.00 43.56 ? 357 PHE A CD1 1 ATOM 2803 C CD2 . PHE A 1 357 ? 107.539 14.055 50.905 1.00 44.17 ? 357 PHE A CD2 1 ATOM 2804 C CE1 . PHE A 1 357 ? 108.956 14.874 48.656 1.00 43.39 ? 357 PHE A CE1 1 ATOM 2805 C CE2 . PHE A 1 357 ? 107.527 15.410 50.538 1.00 46.52 ? 357 PHE A CE2 1 ATOM 2806 C CZ . PHE A 1 357 ? 108.242 15.820 49.401 1.00 42.88 ? 357 PHE A CZ 1 ATOM 2807 N N . PHE A 1 358 ? 106.898 8.576 50.486 1.00 48.80 ? 358 PHE A N 1 ATOM 2808 C CA . PHE A 1 358 ? 107.153 7.131 50.576 1.00 50.10 ? 358 PHE A CA 1 ATOM 2809 C C . PHE A 1 358 ? 105.846 6.319 50.285 1.00 52.01 ? 358 PHE A C 1 ATOM 2810 O O . PHE A 1 358 ? 105.324 5.601 51.146 1.00 52.09 ? 358 PHE A O 1 ATOM 2811 C CB . PHE A 1 358 ? 107.752 6.783 51.933 1.00 48.66 ? 358 PHE A CB 1 ATOM 2812 C CG . PHE A 1 358 ? 109.027 7.500 52.244 1.00 49.35 ? 358 PHE A CG 1 ATOM 2813 C CD1 . PHE A 1 358 ? 109.012 8.731 52.921 1.00 48.49 ? 358 PHE A CD1 1 ATOM 2814 C CD2 . PHE A 1 358 ? 110.269 6.945 51.901 1.00 45.82 ? 358 PHE A CD2 1 ATOM 2815 C CE1 . PHE A 1 358 ? 110.233 9.407 53.237 1.00 45.40 ? 358 PHE A CE1 1 ATOM 2816 C CE2 . PHE A 1 358 ? 111.471 7.627 52.218 1.00 42.62 ? 358 PHE A CE2 1 ATOM 2817 C CZ . PHE A 1 358 ? 111.442 8.832 52.879 1.00 42.80 ? 358 PHE A CZ 1 ATOM 2818 N N . PRO A 1 359 ? 105.320 6.465 49.064 1.00 53.95 ? 359 PRO A N 1 ATOM 2819 C CA . PRO A 1 359 ? 104.001 5.945 48.720 1.00 54.70 ? 359 PRO A CA 1 ATOM 2820 C C . PRO A 1 359 ? 103.811 4.433 48.874 1.00 55.42 ? 359 PRO A C 1 ATOM 2821 O O . PRO A 1 359 ? 102.736 3.994 49.331 1.00 56.58 ? 359 PRO A O 1 ATOM 2822 C CB . PRO A 1 359 ? 103.838 6.374 47.255 1.00 54.99 ? 359 PRO A CB 1 ATOM 2823 C CG . PRO A 1 359 ? 105.236 6.589 46.765 1.00 54.43 ? 359 PRO A CG 1 ATOM 2824 C CD . PRO A 1 359 ? 105.932 7.177 47.922 1.00 53.29 ? 359 PRO A CD 1 ATOM 2825 N N . GLY A 1 360 ? 104.802 3.642 48.487 1.00 55.43 ? 360 GLY A N 1 ATOM 2826 C CA . GLY A 1 360 ? 104.658 2.179 48.536 1.00 55.29 ? 360 GLY A CA 1 ATOM 2827 C C . GLY A 1 360 ? 105.430 1.551 49.708 1.00 55.56 ? 360 GLY A C 1 ATOM 2828 O O . GLY A 1 360 ? 105.804 0.358 49.677 1.00 55.81 ? 360 GLY A O 1 ATOM 2829 N N . VAL A 1 361 ? 105.673 2.356 50.743 1.00 54.06 ? 361 VAL A N 1 ATOM 2830 C CA . VAL A 1 361 ? 106.383 1.894 51.921 1.00 52.40 ? 361 VAL A CA 1 ATOM 2831 C C . VAL A 1 361 ? 105.362 1.380 52.952 1.00 52.01 ? 361 VAL A C 1 ATOM 2832 O O . VAL A 1 361 ? 104.347 2.043 53.243 1.00 51.22 ? 361 VAL A O 1 ATOM 2833 C CB . VAL A 1 361 ? 107.397 2.993 52.466 1.00 52.29 ? 361 VAL A CB 1 ATOM 2834 C CG1 . VAL A 1 361 ? 107.937 2.663 53.847 1.00 50.35 ? 361 VAL A CG1 1 ATOM 2835 C CG2 . VAL A 1 361 ? 108.552 3.162 51.465 1.00 51.48 ? 361 VAL A CG2 1 ATOM 2836 N N . SER A 1 362 ? 105.653 0.185 53.483 1.00 51.29 ? 362 SER A N 1 ATOM 2837 C CA . SER A 1 362 ? 104.903 -0.406 54.577 1.00 50.60 ? 362 SER A CA 1 ATOM 2838 C C . SER A 1 362 ? 104.665 0.593 55.684 1.00 50.38 ? 362 SER A C 1 ATOM 2839 O O . SER A 1 362 ? 105.426 1.550 55.846 1.00 50.61 ? 362 SER A O 1 ATOM 2840 C CB . SER A 1 362 ? 105.693 -1.581 55.137 1.00 50.83 ? 362 SER A CB 1 ATOM 2841 O OG . SER A 1 362 ? 106.889 -1.130 55.731 1.00 49.31 ? 362 SER A OG 1 ATOM 2842 N N A GLU A 1 363 ? 103.626 0.386 56.488 0.50 49.95 ? 363 GLU A N 1 ATOM 2843 N N B GLU A 1 363 ? 103.590 0.350 56.419 0.50 50.23 ? 363 GLU A N 1 ATOM 2844 C CA A GLU A 1 363 ? 103.333 1.327 57.584 0.50 49.64 ? 363 GLU A CA 1 ATOM 2845 C CA B GLU A 1 363 ? 103.209 1.116 57.593 0.50 50.29 ? 363 GLU A CA 1 ATOM 2846 C C A GLU A 1 363 ? 104.373 1.306 58.724 0.50 49.19 ? 363 GLU A C 1 ATOM 2847 C C B GLU A 1 363 ? 104.374 1.275 58.596 0.50 49.52 ? 363 GLU A C 1 ATOM 2848 O O A GLU A 1 363 ? 104.571 2.322 59.423 0.50 49.45 ? 363 GLU A O 1 ATOM 2849 O O B GLU A 1 363 ? 104.664 2.385 59.065 0.50 50.00 ? 363 GLU A O 1 ATOM 2850 C CB A GLU A 1 363 ? 101.903 1.116 58.131 0.50 49.83 ? 363 GLU A CB 1 ATOM 2851 C CB B GLU A 1 363 ? 102.000 0.406 58.241 0.50 50.59 ? 363 GLU A CB 1 ATOM 2852 C CG A GLU A 1 363 ? 101.068 2.403 58.218 0.50 49.79 ? 363 GLU A CG 1 ATOM 2853 C CG B GLU A 1 363 ? 100.987 1.301 58.934 0.50 52.28 ? 363 GLU A CG 1 ATOM 2854 C CD A GLU A 1 363 ? 100.615 2.937 56.856 0.50 48.27 ? 363 GLU A CD 1 ATOM 2855 C CD B GLU A 1 363 ? 101.446 1.768 60.302 0.50 54.54 ? 363 GLU A CD 1 ATOM 2856 O OE1 A GLU A 1 363 ? 100.002 4.022 56.840 0.50 46.63 ? 363 GLU A OE1 1 ATOM 2857 O OE1 B GLU A 1 363 ? 100.812 2.701 60.867 0.50 54.65 ? 363 GLU A OE1 1 ATOM 2858 O OE2 A GLU A 1 363 ? 100.875 2.286 55.804 0.50 46.15 ? 363 GLU A OE2 1 ATOM 2859 O OE2 B GLU A 1 363 ? 102.442 1.199 60.810 0.50 55.93 ? 363 GLU A OE2 1 ATOM 2860 N N . PHE A 1 364 ? 105.009 0.151 58.930 1.00 48.41 ? 364 PHE A N 1 ATOM 2861 C CA . PHE A 1 364 ? 106.160 0.071 59.831 1.00 46.78 ? 364 PHE A CA 1 ATOM 2862 C C . PHE A 1 364 ? 107.367 0.890 59.281 1.00 46.36 ? 364 PHE A C 1 ATOM 2863 O O . PHE A 1 364 ? 108.052 1.571 60.019 1.00 46.71 ? 364 PHE A O 1 ATOM 2864 C CB . PHE A 1 364 ? 106.537 -1.409 60.019 1.00 46.40 ? 364 PHE A CB 1 ATOM 2865 C CG . PHE A 1 364 ? 107.901 -1.634 60.660 1.00 43.91 ? 364 PHE A CG 1 ATOM 2866 C CD1 . PHE A 1 364 ? 108.988 -2.028 59.890 1.00 41.33 ? 364 PHE A CD1 1 ATOM 2867 C CD2 . PHE A 1 364 ? 108.088 -1.439 62.007 1.00 41.62 ? 364 PHE A CD2 1 ATOM 2868 C CE1 . PHE A 1 364 ? 110.238 -2.238 60.462 1.00 42.96 ? 364 PHE A CE1 1 ATOM 2869 C CE2 . PHE A 1 364 ? 109.333 -1.644 62.578 1.00 43.09 ? 364 PHE A CE2 1 ATOM 2870 C CZ . PHE A 1 364 ? 110.403 -2.028 61.820 1.00 40.98 ? 364 PHE A CZ 1 ATOM 2871 N N . GLY A 1 365 ? 107.613 0.819 57.984 1.00 46.31 ? 365 GLY A N 1 ATOM 2872 C CA . GLY A 1 365 ? 108.652 1.628 57.353 1.00 46.83 ? 365 GLY A CA 1 ATOM 2873 C C . GLY A 1 365 ? 108.469 3.089 57.702 1.00 47.41 ? 365 GLY A C 1 ATOM 2874 O O . GLY A 1 365 ? 109.406 3.754 58.180 1.00 47.45 ? 365 GLY A O 1 ATOM 2875 N N . LYS A 1 366 ? 107.238 3.581 57.534 1.00 46.91 ? 366 LYS A N 1 ATOM 2876 C CA . LYS A 1 366 ? 106.975 4.981 57.782 1.00 46.08 ? 366 LYS A CA 1 ATOM 2877 C C . LYS A 1 366 ? 107.020 5.333 59.237 1.00 46.08 ? 366 LYS A C 1 ATOM 2878 O O . LYS A 1 366 ? 107.503 6.430 59.574 1.00 46.50 ? 366 LYS A O 1 ATOM 2879 C CB . LYS A 1 366 ? 105.666 5.457 57.153 1.00 46.39 ? 366 LYS A CB 1 ATOM 2880 C CG . LYS A 1 366 ? 105.644 5.341 55.628 1.00 49.04 ? 366 LYS A CG 1 ATOM 2881 C CD . LYS A 1 366 ? 104.267 5.703 55.022 1.00 51.66 ? 366 LYS A CD 1 ATOM 2882 C CE . LYS A 1 366 ? 103.531 4.458 54.476 1.00 56.16 ? 366 LYS A CE 1 ATOM 2883 N NZ . LYS A 1 366 ? 102.929 4.742 53.082 1.00 58.40 ? 366 LYS A NZ 1 ATOM 2884 N N A GLU A 1 367 ? 106.538 4.454 60.112 0.50 45.40 ? 367 GLU A N 1 ATOM 2885 N N B GLU A 1 367 ? 106.523 4.436 60.104 0.50 45.60 ? 367 GLU A N 1 ATOM 2886 C CA A GLU A 1 367 ? 106.626 4.732 61.546 0.50 44.67 ? 367 GLU A CA 1 ATOM 2887 C CA B GLU A 1 367 ? 106.616 4.616 61.568 0.50 45.09 ? 367 GLU A CA 1 ATOM 2888 C C A GLU A 1 367 ? 108.102 4.824 61.987 0.50 44.14 ? 367 GLU A C 1 ATOM 2889 C C B GLU A 1 367 ? 108.082 4.797 61.989 0.50 44.39 ? 367 GLU A C 1 ATOM 2890 O O A GLU A 1 367 ? 108.470 5.654 62.834 0.50 43.68 ? 367 GLU A O 1 ATOM 2891 O O B GLU A 1 367 ? 108.420 5.645 62.830 0.50 43.98 ? 367 GLU A O 1 ATOM 2892 C CB A GLU A 1 367 ? 105.843 3.692 62.345 0.50 44.57 ? 367 GLU A CB 1 ATOM 2893 C CB B GLU A 1 367 ? 105.995 3.429 62.326 0.50 45.15 ? 367 GLU A CB 1 ATOM 2894 C CG A GLU A 1 367 ? 105.975 3.803 63.850 0.50 45.19 ? 367 GLU A CG 1 ATOM 2895 C CG B GLU A 1 367 ? 104.481 3.485 62.522 0.50 46.90 ? 367 GLU A CG 1 ATOM 2896 C CD A GLU A 1 367 ? 105.290 5.010 64.451 0.50 47.67 ? 367 GLU A CD 1 ATOM 2897 C CD B GLU A 1 367 ? 103.951 2.452 63.536 0.50 48.79 ? 367 GLU A CD 1 ATOM 2898 O OE1 A GLU A 1 367 ? 106.018 5.883 64.976 0.50 50.74 ? 367 GLU A OE1 1 ATOM 2899 O OE1 B GLU A 1 367 ? 103.882 1.235 63.211 0.50 47.68 ? 367 GLU A OE1 1 ATOM 2900 O OE2 A GLU A 1 367 ? 104.042 5.084 64.420 0.50 46.83 ? 367 GLU A OE2 1 ATOM 2901 O OE2 B GLU A 1 367 ? 103.586 2.865 64.667 0.50 48.24 ? 367 GLU A OE2 1 ATOM 2902 N N . SER A 1 368 ? 108.950 4.018 61.358 1.00 43.83 ? 368 SER A N 1 ATOM 2903 C CA . SER A 1 368 ? 110.367 3.989 61.711 1.00 43.25 ? 368 SER A CA 1 ATOM 2904 C C . SER A 1 368 ? 111.094 5.287 61.326 1.00 42.05 ? 368 SER A C 1 ATOM 2905 O O . SER A 1 368 ? 111.941 5.775 62.076 1.00 40.74 ? 368 SER A O 1 ATOM 2906 C CB . SER A 1 368 ? 111.015 2.749 61.130 1.00 42.72 ? 368 SER A CB 1 ATOM 2907 O OG . SER A 1 368 ? 111.447 2.980 59.826 1.00 44.06 ? 368 SER A OG 1 ATOM 2908 N N . ILE A 1 369 ? 110.709 5.870 60.189 1.00 41.24 ? 369 ILE A N 1 ATOM 2909 C CA . ILE A 1 369 ? 111.160 7.228 59.852 1.00 40.55 ? 369 ILE A CA 1 ATOM 2910 C C . ILE A 1 369 ? 110.683 8.195 60.935 1.00 40.86 ? 369 ILE A C 1 ATOM 2911 O O . ILE A 1 369 ? 111.464 8.906 61.509 1.00 41.20 ? 369 ILE A O 1 ATOM 2912 C CB . ILE A 1 369 ? 110.604 7.723 58.487 1.00 39.72 ? 369 ILE A CB 1 ATOM 2913 C CG1 . ILE A 1 369 ? 110.966 6.780 57.347 1.00 38.54 ? 369 ILE A CG1 1 ATOM 2914 C CG2 . ILE A 1 369 ? 111.052 9.135 58.282 1.00 38.83 ? 369 ILE A CG2 1 ATOM 2915 C CD1 . ILE A 1 369 ? 110.378 7.233 56.003 1.00 39.49 ? 369 ILE A CD1 1 ATOM 2916 N N . LEU A 1 370 ? 109.382 8.232 61.196 1.00 42.16 ? 370 LEU A N 1 ATOM 2917 C CA . LEU A 1 370 ? 108.869 9.091 62.201 1.00 43.59 ? 370 LEU A CA 1 ATOM 2918 C C . LEU A 1 370 ? 109.619 8.900 63.505 1.00 43.93 ? 370 LEU A C 1 ATOM 2919 O O . LEU A 1 370 ? 110.003 9.858 64.143 1.00 44.44 ? 370 LEU A O 1 ATOM 2920 C CB . LEU A 1 370 ? 107.363 8.843 62.395 1.00 44.41 ? 370 LEU A CB 1 ATOM 2921 C CG . LEU A 1 370 ? 106.598 9.579 63.503 1.00 44.18 ? 370 LEU A CG 1 ATOM 2922 C CD1 . LEU A 1 370 ? 105.182 9.436 63.167 1.00 48.61 ? 370 LEU A CD1 1 ATOM 2923 C CD2 . LEU A 1 370 ? 106.833 8.947 64.848 1.00 44.14 ? 370 LEU A CD2 1 ATOM 2924 N N . PHE A 1 371 ? 109.801 7.659 63.922 1.00 45.24 ? 371 PHE A N 1 ATOM 2925 C CA . PHE A 1 371 ? 110.533 7.388 65.154 1.00 46.79 ? 371 PHE A CA 1 ATOM 2926 C C . PHE A 1 371 ? 111.942 7.985 65.189 1.00 46.50 ? 371 PHE A C 1 ATOM 2927 O O . PHE A 1 371 ? 112.359 8.557 66.209 1.00 46.47 ? 371 PHE A O 1 ATOM 2928 C CB . PHE A 1 371 ? 110.651 5.884 65.383 1.00 48.20 ? 371 PHE A CB 1 ATOM 2929 C CG . PHE A 1 371 ? 111.384 5.530 66.648 1.00 52.58 ? 371 PHE A CG 1 ATOM 2930 C CD1 . PHE A 1 371 ? 112.724 5.107 66.604 1.00 55.80 ? 371 PHE A CD1 1 ATOM 2931 C CD2 . PHE A 1 371 ? 110.724 5.607 67.892 1.00 55.62 ? 371 PHE A CD2 1 ATOM 2932 C CE1 . PHE A 1 371 ? 113.419 4.775 67.796 1.00 57.30 ? 371 PHE A CE1 1 ATOM 2933 C CE2 . PHE A 1 371 ? 111.411 5.296 69.088 1.00 58.20 ? 371 PHE A CE2 1 ATOM 2934 C CZ . PHE A 1 371 ? 112.749 4.868 69.045 1.00 55.78 ? 371 PHE A CZ 1 ATOM 2935 N N A HIS A 1 372 ? 112.694 7.812 64.099 0.50 46.24 ? 372 HIS A N 1 ATOM 2936 N N B HIS A 1 372 ? 112.681 7.838 64.098 0.50 46.42 ? 372 HIS A N 1 ATOM 2937 C CA A HIS A 1 372 ? 114.062 8.339 64.022 0.50 46.18 ? 372 HIS A CA 1 ATOM 2938 C CA B HIS A 1 372 ? 114.050 8.318 64.096 0.50 46.48 ? 372 HIS A CA 1 ATOM 2939 C C A HIS A 1 372 ? 114.058 9.866 64.068 0.50 46.84 ? 372 HIS A C 1 ATOM 2940 C C B HIS A 1 372 ? 114.165 9.845 63.924 0.50 47.06 ? 372 HIS A C 1 ATOM 2941 O O A HIS A 1 372 ? 114.801 10.485 64.848 0.50 46.63 ? 372 HIS A O 1 ATOM 2942 O O B HIS A 1 372 ? 115.103 10.454 64.449 0.50 46.97 ? 372 HIS A O 1 ATOM 2943 C CB A HIS A 1 372 ? 114.773 7.834 62.759 0.50 45.57 ? 372 HIS A CB 1 ATOM 2944 C CB B HIS A 1 372 ? 114.900 7.499 63.122 0.50 46.15 ? 372 HIS A CB 1 ATOM 2945 C CG A HIS A 1 372 ? 116.260 8.036 62.777 0.50 44.81 ? 372 HIS A CG 1 ATOM 2946 C CG B HIS A 1 372 ? 115.223 6.117 63.628 0.50 45.58 ? 372 HIS A CG 1 ATOM 2947 N ND1 A HIS A 1 372 ? 117.107 7.305 63.588 0.50 43.43 ? 372 HIS A ND1 1 ATOM 2948 N ND1 B HIS A 1 372 ? 114.388 5.035 63.441 0.50 44.05 ? 372 HIS A ND1 1 ATOM 2949 C CD2 A HIS A 1 372 ? 117.053 8.873 62.064 0.50 42.62 ? 372 HIS A CD2 1 ATOM 2950 C CD2 B HIS A 1 372 ? 116.285 5.648 64.329 0.50 43.96 ? 372 HIS A CD2 1 ATOM 2951 C CE1 A HIS A 1 372 ? 118.352 7.703 63.386 0.50 41.10 ? 372 HIS A CE1 1 ATOM 2952 C CE1 B HIS A 1 372 ? 114.926 3.960 63.984 0.50 42.96 ? 372 HIS A CE1 1 ATOM 2953 N NE2 A HIS A 1 372 ? 118.344 8.652 62.470 0.50 39.52 ? 372 HIS A NE2 1 ATOM 2954 N NE2 B HIS A 1 372 ? 116.075 4.303 64.532 0.50 41.56 ? 372 HIS A NE2 1 ATOM 2955 N N . TYR A 1 373 ? 113.182 10.469 63.262 1.00 47.33 ? 373 TYR A N 1 ATOM 2956 C CA . TYR A 1 373 ? 113.184 11.935 63.077 1.00 49.04 ? 373 TYR A CA 1 ATOM 2957 C C . TYR A 1 373 ? 112.376 12.802 64.057 1.00 51.78 ? 373 TYR A C 1 ATOM 2958 O O . TYR A 1 373 ? 112.364 14.050 63.930 1.00 52.52 ? 373 TYR A O 1 ATOM 2959 C CB . TYR A 1 373 ? 112.834 12.260 61.613 1.00 47.87 ? 373 TYR A CB 1 ATOM 2960 C CG . TYR A 1 373 ? 114.038 12.055 60.694 1.00 45.84 ? 373 TYR A CG 1 ATOM 2961 C CD1 . TYR A 1 373 ? 114.887 13.140 60.357 1.00 43.48 ? 373 TYR A CD1 1 ATOM 2962 C CD2 . TYR A 1 373 ? 114.330 10.790 60.163 1.00 40.47 ? 373 TYR A CD2 1 ATOM 2963 C CE1 . TYR A 1 373 ? 116.008 12.946 59.498 1.00 44.32 ? 373 TYR A CE1 1 ATOM 2964 C CE2 . TYR A 1 373 ? 115.428 10.598 59.314 1.00 41.59 ? 373 TYR A CE2 1 ATOM 2965 C CZ . TYR A 1 373 ? 116.266 11.687 58.994 1.00 40.33 ? 373 TYR A CZ 1 ATOM 2966 O OH . TYR A 1 373 ? 117.359 11.503 58.188 1.00 42.13 ? 373 TYR A OH 1 ATOM 2967 N N . THR A 1 374 ? 111.690 12.181 65.017 1.00 54.71 ? 374 THR A N 1 ATOM 2968 C CA . THR A 1 374 ? 110.847 12.981 65.934 1.00 58.49 ? 374 THR A CA 1 ATOM 2969 C C . THR A 1 374 ? 111.212 12.871 67.407 1.00 60.30 ? 374 THR A C 1 ATOM 2970 O O . THR A 1 374 ? 110.387 13.152 68.272 1.00 60.96 ? 374 THR A O 1 ATOM 2971 C CB . THR A 1 374 ? 109.300 12.747 65.721 1.00 58.23 ? 374 THR A CB 1 ATOM 2972 O OG1 . THR A 1 374 ? 108.982 11.368 65.943 1.00 61.21 ? 374 THR A OG1 1 ATOM 2973 C CG2 . THR A 1 374 ? 108.908 12.963 64.281 1.00 58.20 ? 374 THR A CG2 1 ATOM 2974 N N . ASP A 1 375 ? 112.442 12.471 67.706 1.00 63.41 ? 375 ASP A N 1 ATOM 2975 C CA . ASP A 1 375 ? 112.893 12.459 69.101 1.00 65.99 ? 375 ASP A CA 1 ATOM 2976 C C . ASP A 1 375 ? 113.373 13.874 69.440 1.00 67.72 ? 375 ASP A C 1 ATOM 2977 O O . ASP A 1 375 ? 114.580 14.177 69.403 1.00 68.14 ? 375 ASP A O 1 ATOM 2978 C CB . ASP A 1 375 ? 113.986 11.421 69.351 1.00 65.91 ? 375 ASP A CB 1 ATOM 2979 C CG . ASP A 1 375 ? 114.315 11.286 70.837 0.50 67.10 ? 375 ASP A CG 1 ATOM 2980 O OD1 . ASP A 1 375 ? 113.473 10.746 71.596 0.50 65.63 ? 375 ASP A OD1 1 ATOM 2981 O OD2 . ASP A 1 375 ? 115.388 11.707 71.333 0.50 68.17 ? 375 ASP A OD2 1 ATOM 2982 N N . TRP A 1 376 ? 112.397 14.730 69.757 1.00 69.23 ? 376 TRP A N 1 ATOM 2983 C CA . TRP A 1 376 ? 112.589 16.167 69.886 1.00 70.34 ? 376 TRP A CA 1 ATOM 2984 C C . TRP A 1 376 ? 113.587 16.523 70.972 1.00 71.98 ? 376 TRP A C 1 ATOM 2985 O O . TRP A 1 376 ? 113.602 15.900 72.056 1.00 72.53 ? 376 TRP A O 1 ATOM 2986 C CB . TRP A 1 376 ? 111.249 16.870 70.122 1.00 69.92 ? 376 TRP A CB 1 ATOM 2987 C CG . TRP A 1 376 ? 110.277 16.671 68.997 1.00 69.42 ? 376 TRP A CG 1 ATOM 2988 C CD1 . TRP A 1 376 ? 108.952 16.403 69.105 1.00 68.81 ? 376 TRP A CD1 1 ATOM 2989 C CD2 . TRP A 1 376 ? 110.561 16.721 67.588 1.00 69.33 ? 376 TRP A CD2 1 ATOM 2990 N NE1 . TRP A 1 376 ? 108.386 16.286 67.857 1.00 69.37 ? 376 TRP A NE1 1 ATOM 2991 C CE2 . TRP A 1 376 ? 109.352 16.471 66.907 1.00 68.70 ? 376 TRP A CE2 1 ATOM 2992 C CE3 . TRP A 1 376 ? 111.724 16.947 66.828 1.00 68.69 ? 376 TRP A CE3 1 ATOM 2993 C CZ2 . TRP A 1 376 ? 109.265 16.440 65.507 1.00 68.79 ? 376 TRP A CZ2 1 ATOM 2994 C CZ3 . TRP A 1 376 ? 111.634 16.913 65.438 1.00 68.22 ? 376 TRP A CZ3 1 ATOM 2995 C CH2 . TRP A 1 376 ? 110.414 16.665 64.795 1.00 67.19 ? 376 TRP A CH2 1 ATOM 2996 N N . VAL A 1 377 ? 114.389 17.545 70.650 1.00 73.14 ? 377 VAL A N 1 ATOM 2997 C CA . VAL A 1 377 ? 115.601 17.948 71.357 1.00 73.97 ? 377 VAL A CA 1 ATOM 2998 C C . VAL A 1 377 ? 115.503 19.450 71.628 1.00 74.34 ? 377 VAL A C 1 ATOM 2999 O O . VAL A 1 377 ? 114.396 20.015 71.688 1.00 75.23 ? 377 VAL A O 1 ATOM 3000 C CB . VAL A 1 377 ? 116.864 17.637 70.479 1.00 74.21 ? 377 VAL A CB 1 ATOM 3001 C CG1 . VAL A 1 377 ? 118.154 18.256 71.055 1.00 74.42 ? 377 VAL A CG1 1 ATOM 3002 C CG2 . VAL A 1 377 ? 117.020 16.108 70.244 1.00 74.74 ? 377 VAL A CG2 1 ATOM 3003 N N . GLN A 1 380 ? 107.247 20.626 71.511 1.00 77.73 ? 380 GLN A N 1 ATOM 3004 C CA . GLN A 1 380 ? 108.339 21.594 71.652 1.00 78.14 ? 380 GLN A CA 1 ATOM 3005 C C . GLN A 1 380 ? 108.157 22.890 70.779 1.00 77.14 ? 380 GLN A C 1 ATOM 3006 O O . GLN A 1 380 ? 107.076 23.523 70.772 1.00 76.89 ? 380 GLN A O 1 ATOM 3007 C CB . GLN A 1 380 ? 109.699 20.882 71.358 1.00 78.91 ? 380 GLN A CB 1 ATOM 3008 C CG . GLN A 1 380 ? 110.704 20.784 72.533 1.00 80.72 ? 380 GLN A CG 1 ATOM 3009 C CD . GLN A 1 380 ? 111.324 22.157 72.930 1.00 82.19 ? 380 GLN A CD 1 ATOM 3010 O OE1 . GLN A 1 380 ? 112.472 22.467 72.551 1.00 81.67 ? 380 GLN A OE1 1 ATOM 3011 N NE2 . GLN A 1 380 ? 110.568 22.962 73.696 1.00 80.45 ? 380 GLN A NE2 1 ATOM 3012 N N . ARG A 1 381 ? 109.257 23.279 70.111 1.00 75.83 ? 381 ARG A N 1 ATOM 3013 C CA . ARG A 1 381 ? 109.341 24.232 68.985 1.00 73.66 ? 381 ARG A CA 1 ATOM 3014 C C . ARG A 1 381 ? 108.334 23.931 67.866 1.00 71.62 ? 381 ARG A C 1 ATOM 3015 O O . ARG A 1 381 ? 108.176 22.777 67.460 1.00 71.66 ? 381 ARG A O 1 ATOM 3016 C CB . ARG A 1 381 ? 110.742 24.119 68.378 1.00 74.08 ? 381 ARG A CB 1 ATOM 3017 C CG . ARG A 1 381 ? 111.889 23.995 69.394 1.00 74.99 ? 381 ARG A CG 1 ATOM 3018 C CD . ARG A 1 381 ? 113.291 23.752 68.791 1.00 77.65 ? 381 ARG A CD 1 ATOM 3019 N NE . ARG A 1 381 ? 113.594 24.673 67.691 1.00 79.47 ? 381 ARG A NE 1 ATOM 3020 C CZ . ARG A 1 381 ? 113.510 24.357 66.398 1.00 80.84 ? 381 ARG A CZ 1 ATOM 3021 N NH1 . ARG A 1 381 ? 113.779 25.280 65.479 1.00 80.12 ? 381 ARG A NH1 1 ATOM 3022 N NH2 . ARG A 1 381 ? 113.151 23.123 66.021 1.00 79.85 ? 381 ARG A NH2 1 ATOM 3023 N N . PRO A 1 382 ? 107.657 24.959 67.357 1.00 69.68 ? 382 PRO A N 1 ATOM 3024 C CA . PRO A 1 382 ? 106.606 24.764 66.320 1.00 67.29 ? 382 PRO A CA 1 ATOM 3025 C C . PRO A 1 382 ? 107.088 24.301 64.937 1.00 65.01 ? 382 PRO A C 1 ATOM 3026 O O . PRO A 1 382 ? 106.325 23.652 64.230 1.00 63.53 ? 382 PRO A O 1 ATOM 3027 C CB . PRO A 1 382 ? 105.936 26.144 66.227 1.00 67.71 ? 382 PRO A CB 1 ATOM 3028 C CG . PRO A 1 382 ? 106.417 26.903 67.466 1.00 68.75 ? 382 PRO A CG 1 ATOM 3029 C CD . PRO A 1 382 ? 107.806 26.379 67.739 1.00 69.71 ? 382 PRO A CD 1 ATOM 3030 N N . GLU A 1 383 ? 108.326 24.643 64.555 1.00 62.84 ? 383 GLU A N 1 ATOM 3031 C CA . GLU A 1 383 ? 108.902 24.207 63.265 1.00 61.65 ? 383 GLU A CA 1 ATOM 3032 C C . GLU A 1 383 ? 109.506 22.791 63.260 1.00 60.04 ? 383 GLU A C 1 ATOM 3033 O O . GLU A 1 383 ? 110.043 22.339 62.216 1.00 59.10 ? 383 GLU A O 1 ATOM 3034 C CB . GLU A 1 383 ? 109.934 25.203 62.700 1.00 61.88 ? 383 GLU A CB 1 ATOM 3035 C CG . GLU A 1 383 ? 110.975 25.712 63.678 1.00 65.20 ? 383 GLU A CG 1 ATOM 3036 C CD . GLU A 1 383 ? 110.335 26.554 64.764 1.00 70.16 ? 383 GLU A CD 1 ATOM 3037 O OE1 . GLU A 1 383 ? 109.651 27.551 64.431 1.00 72.54 ? 383 GLU A OE1 1 ATOM 3038 O OE2 . GLU A 1 383 ? 110.474 26.195 65.950 1.00 72.39 ? 383 GLU A OE2 1 ATOM 3039 N N . ASN A 1 384 ? 109.424 22.111 64.413 1.00 57.91 ? 384 ASN A N 1 ATOM 3040 C CA . ASN A 1 384 ? 109.896 20.725 64.577 1.00 55.53 ? 384 ASN A CA 1 ATOM 3041 C C . ASN A 1 384 ? 109.490 19.810 63.419 1.00 54.03 ? 384 ASN A C 1 ATOM 3042 O O . ASN A 1 384 ? 110.350 19.253 62.724 1.00 53.54 ? 384 ASN A O 1 ATOM 3043 C CB . ASN A 1 384 ? 109.379 20.142 65.888 1.00 55.70 ? 384 ASN A CB 1 ATOM 3044 C CG . ASN A 1 384 ? 110.258 20.471 67.086 1.00 55.99 ? 384 ASN A CG 1 ATOM 3045 O OD1 . ASN A 1 384 ? 111.332 21.092 66.980 1.00 56.32 ? 384 ASN A OD1 1 ATOM 3046 N ND2 . ASN A 1 384 ? 109.794 20.042 68.257 1.00 57.97 ? 384 ASN A ND2 1 ATOM 3047 N N . TYR A 1 385 ? 108.190 19.670 63.195 1.00 52.74 ? 385 TYR A N 1 ATOM 3048 C CA . TYR A 1 385 ? 107.724 18.801 62.112 1.00 52.39 ? 385 TYR A CA 1 ATOM 3049 C C . TYR A 1 385 ? 108.099 19.266 60.693 1.00 50.59 ? 385 TYR A C 1 ATOM 3050 O O . TYR A 1 385 ? 108.456 18.439 59.834 1.00 49.31 ? 385 TYR A O 1 ATOM 3051 C CB . TYR A 1 385 ? 106.222 18.509 62.223 1.00 52.50 ? 385 TYR A CB 1 ATOM 3052 C CG . TYR A 1 385 ? 105.923 17.579 63.373 1.00 55.11 ? 385 TYR A CG 1 ATOM 3053 C CD1 . TYR A 1 385 ? 106.165 16.201 63.273 1.00 55.50 ? 385 TYR A CD1 1 ATOM 3054 C CD2 . TYR A 1 385 ? 105.416 18.087 64.584 1.00 56.98 ? 385 TYR A CD2 1 ATOM 3055 C CE1 . TYR A 1 385 ? 105.910 15.340 64.368 1.00 56.31 ? 385 TYR A CE1 1 ATOM 3056 C CE2 . TYR A 1 385 ? 105.142 17.260 65.662 1.00 56.66 ? 385 TYR A CE2 1 ATOM 3057 C CZ . TYR A 1 385 ? 105.390 15.891 65.556 1.00 57.81 ? 385 TYR A CZ 1 ATOM 3058 O OH . TYR A 1 385 ? 105.114 15.112 66.638 1.00 57.15 ? 385 TYR A OH 1 ATOM 3059 N N . ARG A 1 386 ? 107.995 20.580 60.467 1.00 48.44 ? 386 ARG A N 1 ATOM 3060 C CA . ARG A 1 386 ? 108.387 21.186 59.201 1.00 46.55 ? 386 ARG A CA 1 ATOM 3061 C C . ARG A 1 386 ? 109.870 20.892 58.876 1.00 45.33 ? 386 ARG A C 1 ATOM 3062 O O . ARG A 1 386 ? 110.214 20.463 57.771 1.00 44.49 ? 386 ARG A O 1 ATOM 3063 C CB . ARG A 1 386 ? 108.157 22.697 59.299 1.00 46.66 ? 386 ARG A CB 1 ATOM 3064 C CG . ARG A 1 386 ? 108.426 23.456 58.023 1.00 45.72 ? 386 ARG A CG 1 ATOM 3065 C CD . ARG A 1 386 ? 108.438 24.921 58.230 1.00 44.34 ? 386 ARG A CD 1 ATOM 3066 N NE . ARG A 1 386 ? 109.684 25.368 58.823 1.00 44.48 ? 386 ARG A NE 1 ATOM 3067 C CZ . ARG A 1 386 ? 109.870 26.579 59.368 1.00 45.13 ? 386 ARG A CZ 1 ATOM 3068 N NH1 . ARG A 1 386 ? 108.867 27.468 59.415 1.00 45.73 ? 386 ARG A NH1 1 ATOM 3069 N NH2 . ARG A 1 386 ? 111.055 26.897 59.869 1.00 40.85 ? 386 ARG A NH2 1 ATOM 3070 N N . GLU A 1 387 ? 110.726 21.124 59.861 1.00 43.82 ? 387 GLU A N 1 ATOM 3071 C CA . GLU A 1 387 ? 112.137 20.883 59.731 1.00 44.95 ? 387 GLU A CA 1 ATOM 3072 C C . GLU A 1 387 ? 112.467 19.421 59.553 1.00 43.57 ? 387 GLU A C 1 ATOM 3073 O O . GLU A 1 387 ? 113.356 19.083 58.774 1.00 42.09 ? 387 GLU A O 1 ATOM 3074 C CB . GLU A 1 387 ? 112.908 21.436 60.940 1.00 45.65 ? 387 GLU A CB 1 ATOM 3075 C CG . GLU A 1 387 ? 112.574 22.875 61.193 1.00 49.82 ? 387 GLU A CG 1 ATOM 3076 C CD . GLU A 1 387 ? 113.805 23.699 61.361 1.00 57.56 ? 387 GLU A CD 1 ATOM 3077 O OE1 . GLU A 1 387 ? 113.772 24.884 60.943 1.00 59.52 ? 387 GLU A OE1 1 ATOM 3078 O OE2 . GLU A 1 387 ? 114.799 23.141 61.900 1.00 60.44 ? 387 GLU A OE2 1 ATOM 3079 N N . ALA A 1 388 ? 111.739 18.563 60.274 1.00 42.67 ? 388 ALA A N 1 ATOM 3080 C CA . ALA A 1 388 ? 112.021 17.128 60.209 1.00 41.94 ? 388 ALA A CA 1 ATOM 3081 C C . ALA A 1 388 ? 111.703 16.535 58.835 1.00 41.32 ? 388 ALA A C 1 ATOM 3082 O O . ALA A 1 388 ? 112.479 15.675 58.378 1.00 41.27 ? 388 ALA A O 1 ATOM 3083 C CB . ALA A 1 388 ? 111.294 16.333 61.340 1.00 41.00 ? 388 ALA A CB 1 ATOM 3084 N N . LEU A 1 389 ? 110.600 16.975 58.197 1.00 39.10 ? 389 LEU A N 1 ATOM 3085 C CA . LEU A 1 389 ? 110.229 16.462 56.861 1.00 39.46 ? 389 LEU A CA 1 ATOM 3086 C C . LEU A 1 389 ? 111.229 16.786 55.748 1.00 39.00 ? 389 LEU A C 1 ATOM 3087 O O . LEU A 1 389 ? 111.523 15.943 54.938 1.00 38.89 ? 389 LEU A O 1 ATOM 3088 C CB . LEU A 1 389 ? 108.770 16.802 56.439 1.00 39.22 ? 389 LEU A CB 1 ATOM 3089 C CG . LEU A 1 389 ? 108.216 16.055 55.200 1.00 40.62 ? 389 LEU A CG 1 ATOM 3090 C CD1 . LEU A 1 389 ? 108.093 14.526 55.417 1.00 42.01 ? 389 LEU A CD1 1 ATOM 3091 C CD2 . LEU A 1 389 ? 106.866 16.658 54.714 1.00 39.32 ? 389 LEU A CD2 1 ATOM 3092 N N . GLY A 1 390 ? 111.737 18.013 55.720 1.00 39.88 ? 390 GLY A N 1 ATOM 3093 C CA . GLY A 1 390 ? 112.831 18.382 54.833 1.00 39.57 ? 390 GLY A CA 1 ATOM 3094 C C . GLY A 1 390 ? 114.104 17.596 55.065 1.00 39.37 ? 390 GLY A C 1 ATOM 3095 O O . GLY A 1 390 ? 114.749 17.186 54.108 1.00 39.14 ? 390 GLY A O 1 ATOM 3096 N N . ASP A 1 391 ? 114.498 17.416 56.324 1.00 39.99 ? 391 ASP A N 1 ATOM 3097 C CA . ASP A 1 391 ? 115.658 16.531 56.655 1.00 40.29 ? 391 ASP A CA 1 ATOM 3098 C C . ASP A 1 391 ? 115.451 15.096 56.176 1.00 39.96 ? 391 ASP A C 1 ATOM 3099 O O . ASP A 1 391 ? 116.311 14.517 55.500 1.00 39.80 ? 391 ASP A O 1 ATOM 3100 C CB . ASP A 1 391 ? 115.950 16.562 58.153 1.00 41.07 ? 391 ASP A CB 1 ATOM 3101 C CG . ASP A 1 391 ? 116.549 17.898 58.589 1.00 44.64 ? 391 ASP A CG 1 ATOM 3102 O OD1 . ASP A 1 391 ? 117.300 18.545 57.800 1.00 45.86 ? 391 ASP A OD1 1 ATOM 3103 O OD2 . ASP A 1 391 ? 116.311 18.397 59.702 1.00 51.00 ? 391 ASP A OD2 1 ATOM 3104 N N . VAL A 1 392 ? 114.273 14.546 56.458 1.00 39.57 ? 392 VAL A N 1 ATOM 3105 C CA . VAL A 1 392 ? 113.918 13.219 55.973 1.00 38.80 ? 392 VAL A CA 1 ATOM 3106 C C . VAL A 1 392 ? 114.213 13.168 54.483 1.00 38.63 ? 392 VAL A C 1 ATOM 3107 O O . VAL A 1 392 ? 114.920 12.281 54.026 1.00 38.64 ? 392 VAL A O 1 ATOM 3108 C CB . VAL A 1 392 ? 112.412 12.883 56.269 1.00 38.75 ? 392 VAL A CB 1 ATOM 3109 C CG1 . VAL A 1 392 ? 111.951 11.689 55.468 1.00 39.78 ? 392 VAL A CG1 1 ATOM 3110 C CG2 . VAL A 1 392 ? 112.236 12.559 57.675 1.00 36.69 ? 392 VAL A CG2 1 ATOM 3111 N N . VAL A 1 393 ? 113.685 14.143 53.735 1.00 38.05 ? 393 VAL A N 1 ATOM 3112 C CA . VAL A 1 393 ? 113.744 14.096 52.253 1.00 37.39 ? 393 VAL A CA 1 ATOM 3113 C C . VAL A 1 393 ? 115.164 14.298 51.714 1.00 35.50 ? 393 VAL A C 1 ATOM 3114 O O . VAL A 1 393 ? 115.569 13.619 50.753 1.00 35.81 ? 393 VAL A O 1 ATOM 3115 C CB . VAL A 1 393 ? 112.748 15.127 51.589 1.00 36.66 ? 393 VAL A CB 1 ATOM 3116 C CG1 . VAL A 1 393 ? 112.861 15.073 50.060 1.00 37.46 ? 393 VAL A CG1 1 ATOM 3117 C CG2 . VAL A 1 393 ? 111.309 14.807 52.036 1.00 37.70 ? 393 VAL A CG2 1 ATOM 3118 N N . GLY A 1 394 ? 115.884 15.240 52.314 1.00 33.44 ? 394 GLY A N 1 ATOM 3119 C CA . GLY A 1 394 ? 117.265 15.504 51.934 1.00 34.62 ? 394 GLY A CA 1 ATOM 3120 C C . GLY A 1 394 ? 118.239 14.392 52.308 1.00 34.75 ? 394 GLY A C 1 ATOM 3121 O O . GLY A 1 394 ? 119.141 14.054 51.520 1.00 35.49 ? 394 GLY A O 1 ATOM 3122 N N . ASP A 1 395 ? 118.074 13.814 53.502 1.00 34.87 ? 395 ASP A N 1 ATOM 3123 C CA . ASP A 1 395 ? 119.006 12.757 53.969 1.00 35.08 ? 395 ASP A CA 1 ATOM 3124 C C . ASP A 1 395 ? 118.835 11.490 53.141 1.00 35.32 ? 395 ASP A C 1 ATOM 3125 O O . ASP A 1 395 ? 119.808 10.932 52.624 1.00 35.62 ? 395 ASP A O 1 ATOM 3126 C CB . ASP A 1 395 ? 118.771 12.427 55.427 1.00 35.20 ? 395 ASP A CB 1 ATOM 3127 C CG . ASP A 1 395 ? 119.129 13.568 56.342 1.00 37.72 ? 395 ASP A CG 1 ATOM 3128 O OD1 . ASP A 1 395 ? 118.741 13.479 57.512 1.00 36.70 ? 395 ASP A OD1 1 ATOM 3129 O OD2 . ASP A 1 395 ? 119.741 14.605 55.982 1.00 38.68 ? 395 ASP A OD2 1 ATOM 3130 N N . TYR A 1 396 ? 117.587 11.053 53.021 1.00 35.07 ? 396 TYR A N 1 ATOM 3131 C CA . TYR A 1 396 ? 117.240 9.875 52.260 1.00 35.20 ? 396 TYR A CA 1 ATOM 3132 C C . TYR A 1 396 ? 117.625 10.033 50.786 1.00 34.85 ? 396 TYR A C 1 ATOM 3133 O O . TYR A 1 396 ? 118.273 9.195 50.205 1.00 35.70 ? 396 TYR A O 1 ATOM 3134 C CB . TYR A 1 396 ? 115.724 9.604 52.418 1.00 35.60 ? 396 TYR A CB 1 ATOM 3135 C CG . TYR A 1 396 ? 115.217 8.499 51.534 1.00 36.28 ? 396 TYR A CG 1 ATOM 3136 C CD1 . TYR A 1 396 ? 115.692 7.186 51.670 1.00 37.45 ? 396 TYR A CD1 1 ATOM 3137 C CD2 . TYR A 1 396 ? 114.287 8.765 50.526 1.00 38.89 ? 396 TYR A CD2 1 ATOM 3138 C CE1 . TYR A 1 396 ? 115.226 6.128 50.812 1.00 38.12 ? 396 TYR A CE1 1 ATOM 3139 C CE2 . TYR A 1 396 ? 113.811 7.726 49.660 1.00 40.48 ? 396 TYR A CE2 1 ATOM 3140 C CZ . TYR A 1 396 ? 114.272 6.425 49.835 1.00 38.41 ? 396 TYR A CZ 1 ATOM 3141 O OH . TYR A 1 396 ? 113.819 5.447 49.009 1.00 38.45 ? 396 TYR A OH 1 ATOM 3142 N N . ASN A 1 397 ? 117.228 11.134 50.191 1.00 34.22 ? 397 ASN A N 1 ATOM 3143 C CA . ASN A 1 397 ? 117.434 11.344 48.751 1.00 32.90 ? 397 ASN A CA 1 ATOM 3144 C C . ASN A 1 397 ? 118.792 11.821 48.256 1.00 31.48 ? 397 ASN A C 1 ATOM 3145 O O . ASN A 1 397 ? 119.159 11.463 47.167 1.00 31.13 ? 397 ASN A O 1 ATOM 3146 C CB . ASN A 1 397 ? 116.317 12.244 48.210 1.00 32.00 ? 397 ASN A CB 1 ATOM 3147 C CG . ASN A 1 397 ? 115.055 11.484 48.078 1.00 33.41 ? 397 ASN A CG 1 ATOM 3148 O OD1 . ASN A 1 397 ? 114.923 10.629 47.176 1.00 31.41 ? 397 ASN A OD1 1 ATOM 3149 N ND2 . ASN A 1 397 ? 114.138 11.692 49.026 1.00 31.92 ? 397 ASN A ND2 1 ATOM 3150 N N . PHE A 1 398 ? 119.504 12.647 49.017 1.00 30.67 ? 398 PHE A N 1 ATOM 3151 C CA . PHE A 1 398 ? 120.757 13.208 48.533 1.00 31.66 ? 398 PHE A CA 1 ATOM 3152 C C . PHE A 1 398 ? 121.981 13.001 49.432 1.00 31.90 ? 398 PHE A C 1 ATOM 3153 O O . PHE A 1 398 ? 123.055 12.597 48.948 1.00 31.69 ? 398 PHE A O 1 ATOM 3154 C CB . PHE A 1 398 ? 120.563 14.703 48.230 1.00 32.06 ? 398 PHE A CB 1 ATOM 3155 C CG . PHE A 1 398 ? 119.477 14.959 47.201 1.00 33.06 ? 398 PHE A CG 1 ATOM 3156 C CD1 . PHE A 1 398 ? 118.161 15.238 47.611 1.00 31.69 ? 398 PHE A CD1 1 ATOM 3157 C CD2 . PHE A 1 398 ? 119.761 14.864 45.840 1.00 31.43 ? 398 PHE A CD2 1 ATOM 3158 C CE1 . PHE A 1 398 ? 117.118 15.452 46.676 1.00 33.77 ? 398 PHE A CE1 1 ATOM 3159 C CE2 . PHE A 1 398 ? 118.746 15.075 44.883 1.00 37.53 ? 398 PHE A CE2 1 ATOM 3160 C CZ . PHE A 1 398 ? 117.408 15.368 45.301 1.00 36.29 ? 398 PHE A CZ 1 ATOM 3161 N N . ILE A 1 399 ? 121.837 13.332 50.711 1.00 32.89 ? 399 ILE A N 1 ATOM 3162 C CA . ILE A 1 399 ? 123.001 13.497 51.611 1.00 33.97 ? 399 ILE A CA 1 ATOM 3163 C C . ILE A 1 399 ? 123.583 12.124 51.947 1.00 35.06 ? 399 ILE A C 1 ATOM 3164 O O . ILE A 1 399 ? 124.746 11.866 51.638 1.00 35.92 ? 399 ILE A O 1 ATOM 3165 C CB . ILE A 1 399 ? 122.602 14.293 52.871 1.00 33.93 ? 399 ILE A CB 1 ATOM 3166 C CG1 . ILE A 1 399 ? 122.168 15.733 52.480 1.00 35.27 ? 399 ILE A CG1 1 ATOM 3167 C CG2 . ILE A 1 399 ? 123.729 14.262 53.953 1.00 33.76 ? 399 ILE A CG2 1 ATOM 3168 C CD1 . ILE A 1 399 ? 122.149 16.731 53.635 1.00 36.89 ? 399 ILE A CD1 1 ATOM 3169 N N . CYS A 1 400 ? 122.761 11.231 52.537 1.00 35.77 ? 400 CYS A N 1 ATOM 3170 C CA . CYS A 1 400 ? 123.207 9.900 52.863 1.00 34.92 ? 400 CYS A CA 1 ATOM 3171 C C . CYS A 1 400 ? 123.748 9.096 51.666 1.00 34.78 ? 400 CYS A C 1 ATOM 3172 O O . CYS A 1 400 ? 124.787 8.464 51.814 1.00 34.26 ? 400 CYS A O 1 ATOM 3173 C CB . CYS A 1 400 ? 122.159 9.168 53.671 1.00 36.26 ? 400 CYS A CB 1 ATOM 3174 S SG . CYS A 1 400 ? 121.775 10.005 55.237 1.00 41.14 ? 400 CYS A SG 1 ATOM 3175 N N . PRO A 1 401 ? 123.096 9.095 50.492 1.00 34.45 ? 401 PRO A N 1 ATOM 3176 C CA . PRO A 1 401 ? 123.701 8.447 49.317 1.00 33.90 ? 401 PRO A CA 1 ATOM 3177 C C . PRO A 1 401 ? 125.047 9.071 48.869 1.00 34.90 ? 401 PRO A C 1 ATOM 3178 O O . PRO A 1 401 ? 125.976 8.315 48.478 1.00 35.41 ? 401 PRO A O 1 ATOM 3179 C CB . PRO A 1 401 ? 122.645 8.582 48.211 1.00 32.31 ? 401 PRO A CB 1 ATOM 3180 C CG . PRO A 1 401 ? 121.415 8.927 48.873 1.00 33.37 ? 401 PRO A CG 1 ATOM 3181 C CD . PRO A 1 401 ? 121.743 9.598 50.205 1.00 33.53 ? 401 PRO A CD 1 ATOM 3182 N N . ALA A 1 402 ? 125.175 10.399 48.929 1.00 34.34 ? 402 ALA A N 1 ATOM 3183 C CA . ALA A 1 402 ? 126.426 11.025 48.510 1.00 35.26 ? 402 ALA A CA 1 ATOM 3184 C C . ALA A 1 402 ? 127.581 10.640 49.457 1.00 35.91 ? 402 ALA A C 1 ATOM 3185 O O . ALA A 1 402 ? 128.708 10.336 49.002 1.00 34.59 ? 402 ALA A O 1 ATOM 3186 C CB . ALA A 1 402 ? 126.284 12.534 48.369 1.00 34.79 ? 402 ALA A CB 1 ATOM 3187 N N . LEU A 1 403 ? 127.286 10.648 50.760 1.00 35.86 ? 403 LEU A N 1 ATOM 3188 C CA . LEU A 1 403 ? 128.236 10.233 51.760 1.00 37.35 ? 403 LEU A CA 1 ATOM 3189 C C . LEU A 1 403 ? 128.610 8.749 51.647 1.00 37.78 ? 403 LEU A C 1 ATOM 3190 O O . LEU A 1 403 ? 129.755 8.405 51.751 1.00 38.42 ? 403 LEU A O 1 ATOM 3191 C CB . LEU A 1 403 ? 127.689 10.523 53.147 1.00 38.35 ? 403 LEU A CB 1 ATOM 3192 C CG . LEU A 1 403 ? 127.775 11.970 53.637 1.00 36.24 ? 403 LEU A CG 1 ATOM 3193 C CD1 . LEU A 1 403 ? 126.849 12.094 54.851 1.00 35.91 ? 403 LEU A CD1 1 ATOM 3194 C CD2 . LEU A 1 403 ? 129.269 12.310 53.972 1.00 29.91 ? 403 LEU A CD2 1 ATOM 3195 N N . GLU A 1 404 ? 127.650 7.884 51.383 1.00 39.32 ? 404 GLU A N 1 ATOM 3196 C CA . GLU A 1 404 ? 127.935 6.455 51.151 1.00 40.74 ? 404 GLU A CA 1 ATOM 3197 C C . GLU A 1 404 ? 128.727 6.227 49.839 1.00 39.30 ? 404 GLU A C 1 ATOM 3198 O O . GLU A 1 404 ? 129.658 5.438 49.778 1.00 39.30 ? 404 GLU A O 1 ATOM 3199 C CB . GLU A 1 404 ? 126.635 5.651 51.170 1.00 40.74 ? 404 GLU A CB 1 ATOM 3200 C CG . GLU A 1 404 ? 126.853 4.170 51.479 1.00 50.29 ? 404 GLU A CG 1 ATOM 3201 C CD . GLU A 1 404 ? 127.659 3.915 52.787 1.00 56.08 ? 404 GLU A CD 1 ATOM 3202 O OE1 . GLU A 1 404 ? 127.482 4.646 53.811 1.00 58.47 ? 404 GLU A OE1 1 ATOM 3203 O OE2 . GLU A 1 404 ? 128.463 2.964 52.798 1.00 59.03 ? 404 GLU A OE2 1 ATOM 3204 N N . PHE A 1 405 ? 128.362 6.944 48.785 1.00 38.15 ? 405 PHE A N 1 ATOM 3205 C CA . PHE A 1 405 ? 129.132 6.880 47.580 1.00 36.40 ? 405 PHE A CA 1 ATOM 3206 C C . PHE A 1 405 ? 130.625 7.236 47.842 1.00 36.48 ? 405 PHE A C 1 ATOM 3207 O O . PHE A 1 405 ? 131.530 6.533 47.352 1.00 35.81 ? 405 PHE A O 1 ATOM 3208 C CB . PHE A 1 405 ? 128.561 7.824 46.538 1.00 35.78 ? 405 PHE A CB 1 ATOM 3209 C CG . PHE A 1 405 ? 129.409 7.897 45.325 1.00 35.44 ? 405 PHE A CG 1 ATOM 3210 C CD1 . PHE A 1 405 ? 129.261 6.957 44.309 1.00 33.18 ? 405 PHE A CD1 1 ATOM 3211 C CD2 . PHE A 1 405 ? 130.411 8.844 45.233 1.00 33.23 ? 405 PHE A CD2 1 ATOM 3212 C CE1 . PHE A 1 405 ? 130.096 6.992 43.188 1.00 35.52 ? 405 PHE A CE1 1 ATOM 3213 C CE2 . PHE A 1 405 ? 131.242 8.884 44.116 1.00 35.02 ? 405 PHE A CE2 1 ATOM 3214 C CZ . PHE A 1 405 ? 131.058 7.960 43.086 1.00 34.51 ? 405 PHE A CZ 1 ATOM 3215 N N . THR A 1 406 ? 130.866 8.343 48.567 1.00 35.14 ? 406 THR A N 1 ATOM 3216 C CA . THR A 1 406 ? 132.197 8.807 48.879 1.00 35.53 ? 406 THR A CA 1 ATOM 3217 C C . THR A 1 406 ? 132.973 7.812 49.737 1.00 35.82 ? 406 THR A C 1 ATOM 3218 O O . THR A 1 406 ? 134.143 7.561 49.468 1.00 37.69 ? 406 THR A O 1 ATOM 3219 C CB . THR A 1 406 ? 132.135 10.168 49.546 1.00 35.36 ? 406 THR A CB 1 ATOM 3220 O OG1 . THR A 1 406 ? 131.346 11.074 48.732 1.00 37.03 ? 406 THR A OG1 1 ATOM 3221 C CG2 . THR A 1 406 ? 133.552 10.820 49.608 1.00 36.29 ? 406 THR A CG2 1 ATOM 3222 N N . LYS A 1 407 ? 132.359 7.257 50.767 1.00 36.37 ? 407 LYS A N 1 ATOM 3223 C CA . LYS A 1 407 ? 132.998 6.219 51.562 1.00 37.84 ? 407 LYS A CA 1 ATOM 3224 C C . LYS A 1 407 ? 133.419 5.090 50.682 1.00 37.72 ? 407 LYS A C 1 ATOM 3225 O O . LYS A 1 407 ? 134.584 4.725 50.638 1.00 37.28 ? 407 LYS A O 1 ATOM 3226 C CB . LYS A 1 407 ? 132.054 5.654 52.590 1.00 38.24 ? 407 LYS A CB 1 ATOM 3227 C CG . LYS A 1 407 ? 132.078 6.409 53.840 1.00 44.51 ? 407 LYS A CG 1 ATOM 3228 C CD . LYS A 1 407 ? 131.118 5.801 54.831 1.00 53.37 ? 407 LYS A CD 1 ATOM 3229 C CE . LYS A 1 407 ? 130.187 6.895 55.465 1.00 55.15 ? 407 LYS A CE 1 ATOM 3230 N NZ . LYS A 1 407 ? 129.449 6.317 56.700 1.00 57.71 ? 407 LYS A NZ 1 ATOM 3231 N N . LYS A 1 408 ? 132.468 4.541 49.949 1.00 37.34 ? 408 LYS A N 1 ATOM 3232 C CA . LYS A 1 408 ? 132.778 3.344 49.175 1.00 37.87 ? 408 LYS A CA 1 ATOM 3233 C C . LYS A 1 408 ? 133.812 3.546 48.069 1.00 37.10 ? 408 LYS A C 1 ATOM 3234 O O . LYS A 1 408 ? 134.606 2.652 47.787 1.00 37.19 ? 408 LYS A O 1 ATOM 3235 C CB . LYS A 1 408 ? 131.501 2.688 48.664 1.00 37.24 ? 408 LYS A CB 1 ATOM 3236 C CG . LYS A 1 408 ? 130.770 2.070 49.788 1.00 42.35 ? 408 LYS A CG 1 ATOM 3237 C CD . LYS A 1 408 ? 129.593 1.224 49.347 1.00 52.86 ? 408 LYS A CD 1 ATOM 3238 C CE . LYS A 1 408 ? 128.909 0.601 50.600 1.00 55.61 ? 408 LYS A CE 1 ATOM 3239 N NZ . LYS A 1 408 ? 129.934 0.122 51.647 1.00 58.17 ? 408 LYS A NZ 1 ATOM 3240 N N . PHE A 1 409 ? 133.815 4.723 47.459 1.00 37.07 ? 409 PHE A N 1 ATOM 3241 C CA . PHE A 1 409 ? 134.755 5.015 46.391 1.00 36.49 ? 409 PHE A CA 1 ATOM 3242 C C . PHE A 1 409 ? 136.143 5.171 47.011 1.00 37.55 ? 409 PHE A C 1 ATOM 3243 O O . PHE A 1 409 ? 137.139 4.705 46.462 1.00 38.82 ? 409 PHE A O 1 ATOM 3244 C CB . PHE A 1 409 ? 134.301 6.290 45.635 1.00 36.26 ? 409 PHE A CB 1 ATOM 3245 C CG . PHE A 1 409 ? 135.043 6.548 44.322 1.00 33.96 ? 409 PHE A CG 1 ATOM 3246 C CD1 . PHE A 1 409 ? 134.485 6.185 43.102 1.00 33.32 ? 409 PHE A CD1 1 ATOM 3247 C CD2 . PHE A 1 409 ? 136.293 7.148 44.318 1.00 31.86 ? 409 PHE A CD2 1 ATOM 3248 C CE1 . PHE A 1 409 ? 135.234 6.411 41.883 1.00 34.37 ? 409 PHE A CE1 1 ATOM 3249 C CE2 . PHE A 1 409 ? 137.002 7.418 43.105 1.00 30.62 ? 409 PHE A CE2 1 ATOM 3250 C CZ . PHE A 1 409 ? 136.483 7.012 41.914 1.00 30.55 ? 409 PHE A CZ 1 ATOM 3251 N N . SER A 1 410 ? 136.252 5.834 48.158 1.00 38.48 ? 410 SER A N 1 ATOM 3252 C CA . SER A 1 410 ? 137.585 6.150 48.647 1.00 39.25 ? 410 SER A CA 1 ATOM 3253 C C . SER A 1 410 ? 138.246 4.898 49.216 1.00 40.02 ? 410 SER A C 1 ATOM 3254 O O . SER A 1 410 ? 139.447 4.845 49.344 1.00 39.35 ? 410 SER A O 1 ATOM 3255 C CB . SER A 1 410 ? 137.554 7.290 49.666 1.00 39.33 ? 410 SER A CB 1 ATOM 3256 O OG . SER A 1 410 ? 136.746 6.897 50.726 1.00 42.84 ? 410 SER A OG 1 ATOM 3257 N N . GLU A 1 411 ? 137.461 3.861 49.513 1.00 41.78 ? 411 GLU A N 1 ATOM 3258 C CA . GLU A 1 411 ? 138.017 2.657 50.109 1.00 42.84 ? 411 GLU A CA 1 ATOM 3259 C C . GLU A 1 411 ? 138.876 1.899 49.137 1.00 42.95 ? 411 GLU A C 1 ATOM 3260 O O . GLU A 1 411 ? 139.607 0.987 49.556 1.00 43.66 ? 411 GLU A O 1 ATOM 3261 C CB . GLU A 1 411 ? 136.918 1.745 50.601 1.00 43.78 ? 411 GLU A CB 1 ATOM 3262 C CG . GLU A 1 411 ? 136.635 1.998 52.069 1.00 49.20 ? 411 GLU A CG 1 ATOM 3263 C CD . GLU A 1 411 ? 135.229 1.589 52.437 1.00 56.20 ? 411 GLU A CD 1 ATOM 3264 O OE1 . GLU A 1 411 ? 134.604 0.855 51.642 1.00 58.24 ? 411 GLU A OE1 1 ATOM 3265 O OE2 . GLU A 1 411 ? 134.735 2.014 53.507 1.00 61.11 ? 411 GLU A OE2 1 ATOM 3266 N N . TRP A 1 412 ? 138.814 2.282 47.858 1.00 42.72 ? 412 TRP A N 1 ATOM 3267 C CA . TRP A 1 412 ? 139.661 1.701 46.802 1.00 42.13 ? 412 TRP A CA 1 ATOM 3268 C C . TRP A 1 412 ? 140.904 2.487 46.501 1.00 41.86 ? 412 TRP A C 1 ATOM 3269 O O . TRP A 1 412 ? 141.550 2.242 45.502 1.00 41.27 ? 412 TRP A O 1 ATOM 3270 C CB . TRP A 1 412 ? 138.847 1.459 45.521 1.00 42.78 ? 412 TRP A CB 1 ATOM 3271 C CG . TRP A 1 412 ? 137.924 0.327 45.757 1.00 44.16 ? 412 TRP A CG 1 ATOM 3272 C CD1 . TRP A 1 412 ? 136.661 0.374 46.303 1.00 43.15 ? 412 TRP A CD1 1 ATOM 3273 C CD2 . TRP A 1 412 ? 138.227 -1.063 45.552 1.00 45.89 ? 412 TRP A CD2 1 ATOM 3274 N NE1 . TRP A 1 412 ? 136.149 -0.901 46.420 1.00 45.36 ? 412 TRP A NE1 1 ATOM 3275 C CE2 . TRP A 1 412 ? 137.083 -1.805 45.952 1.00 46.05 ? 412 TRP A CE2 1 ATOM 3276 C CE3 . TRP A 1 412 ? 139.340 -1.760 45.028 1.00 47.31 ? 412 TRP A CE3 1 ATOM 3277 C CZ2 . TRP A 1 412 ? 137.020 -3.210 45.848 1.00 47.97 ? 412 TRP A CZ2 1 ATOM 3278 C CZ3 . TRP A 1 412 ? 139.275 -3.193 44.922 1.00 48.14 ? 412 TRP A CZ3 1 ATOM 3279 C CH2 . TRP A 1 412 ? 138.125 -3.882 45.334 1.00 47.46 ? 412 TRP A CH2 1 ATOM 3280 N N . GLY A 1 413 ? 141.268 3.433 47.363 1.00 42.12 ? 413 GLY A N 1 ATOM 3281 C CA . GLY A 1 413 ? 142.601 4.008 47.250 1.00 42.00 ? 413 GLY A CA 1 ATOM 3282 C C . GLY A 1 413 ? 142.690 5.447 46.820 1.00 42.78 ? 413 GLY A C 1 ATOM 3283 O O . GLY A 1 413 ? 143.686 6.087 47.062 1.00 44.06 ? 413 GLY A O 1 ATOM 3284 N N . ASN A 1 414 ? 141.655 5.998 46.189 1.00 43.74 ? 414 ASN A N 1 ATOM 3285 C CA . ASN A 1 414 ? 141.819 7.322 45.579 1.00 42.44 ? 414 ASN A CA 1 ATOM 3286 C C . ASN A 1 414 ? 141.430 8.405 46.541 1.00 41.09 ? 414 ASN A C 1 ATOM 3287 O O . ASN A 1 414 ? 140.567 8.198 47.368 1.00 40.60 ? 414 ASN A O 1 ATOM 3288 C CB . ASN A 1 414 ? 140.935 7.450 44.340 1.00 43.98 ? 414 ASN A CB 1 ATOM 3289 C CG . ASN A 1 414 ? 141.404 6.595 43.164 1.00 44.02 ? 414 ASN A CG 1 ATOM 3290 O OD1 . ASN A 1 414 ? 140.721 5.633 42.814 1.00 41.89 ? 414 ASN A OD1 1 ATOM 3291 N ND2 . ASN A 1 414 ? 142.562 6.965 42.532 1.00 40.48 ? 414 ASN A ND2 1 ATOM 3292 N N . ASN A 1 415 ? 142.050 9.572 46.389 1.00 40.74 ? 415 ASN A N 1 ATOM 3293 C CA . ASN A 1 415 ? 141.661 10.781 47.089 1.00 40.20 ? 415 ASN A CA 1 ATOM 3294 C C . ASN A 1 415 ? 140.260 11.299 46.765 1.00 39.88 ? 415 ASN A C 1 ATOM 3295 O O . ASN A 1 415 ? 139.854 11.372 45.593 1.00 39.08 ? 415 ASN A O 1 ATOM 3296 C CB . ASN A 1 415 ? 142.664 11.895 46.807 1.00 41.39 ? 415 ASN A CB 1 ATOM 3297 C CG . ASN A 1 415 ? 143.972 11.715 47.564 1.00 41.72 ? 415 ASN A CG 1 ATOM 3298 O OD1 . ASN A 1 415 ? 144.154 10.745 48.303 1.00 45.66 ? 415 ASN A OD1 1 ATOM 3299 N ND2 . ASN A 1 415 ? 144.872 12.656 47.394 1.00 38.45 ? 415 ASN A ND2 1 ATOM 3300 N N . ALA A 1 416 ? 139.560 11.708 47.825 1.00 38.46 ? 416 ALA A N 1 ATOM 3301 C CA . ALA A 1 416 ? 138.187 12.157 47.712 1.00 37.38 ? 416 ALA A CA 1 ATOM 3302 C C . ALA A 1 416 ? 138.040 13.311 48.661 1.00 36.98 ? 416 ALA A C 1 ATOM 3303 O O . ALA A 1 416 ? 138.647 13.322 49.743 1.00 36.63 ? 416 ALA A O 1 ATOM 3304 C CB . ALA A 1 416 ? 137.203 11.018 48.061 1.00 36.88 ? 416 ALA A CB 1 ATOM 3305 N N . PHE A 1 417 ? 137.250 14.295 48.243 1.00 36.41 ? 417 PHE A N 1 ATOM 3306 C CA . PHE A 1 417 ? 137.052 15.542 48.987 1.00 35.46 ? 417 PHE A CA 1 ATOM 3307 C C . PHE A 1 417 ? 135.539 15.762 49.070 1.00 35.35 ? 417 PHE A C 1 ATOM 3308 O O . PHE A 1 417 ? 134.824 15.665 48.067 1.00 34.57 ? 417 PHE A O 1 ATOM 3309 C CB . PHE A 1 417 ? 137.779 16.715 48.291 1.00 35.32 ? 417 PHE A CB 1 ATOM 3310 C CG . PHE A 1 417 ? 139.261 16.427 47.982 1.00 35.16 ? 417 PHE A CG 1 ATOM 3311 C CD1 . PHE A 1 417 ? 139.643 15.819 46.765 1.00 33.67 ? 417 PHE A CD1 1 ATOM 3312 C CD2 . PHE A 1 417 ? 140.261 16.748 48.910 1.00 36.52 ? 417 PHE A CD2 1 ATOM 3313 C CE1 . PHE A 1 417 ? 141.002 15.511 46.468 1.00 28.70 ? 417 PHE A CE1 1 ATOM 3314 C CE2 . PHE A 1 417 ? 141.636 16.449 48.625 1.00 34.18 ? 417 PHE A CE2 1 ATOM 3315 C CZ . PHE A 1 417 ? 141.990 15.820 47.386 1.00 31.96 ? 417 PHE A CZ 1 ATOM 3316 N N . PHE A 1 418 ? 135.050 16.000 50.279 1.00 34.39 ? 418 PHE A N 1 ATOM 3317 C CA . PHE A 1 418 ? 133.609 16.134 50.485 1.00 33.47 ? 418 PHE A CA 1 ATOM 3318 C C . PHE A 1 418 ? 133.349 17.537 51.056 1.00 34.28 ? 418 PHE A C 1 ATOM 3319 O O . PHE A 1 418 ? 134.067 17.957 52.019 1.00 32.94 ? 418 PHE A O 1 ATOM 3320 C CB . PHE A 1 418 ? 133.080 15.062 51.460 1.00 31.22 ? 418 PHE A CB 1 ATOM 3321 C CG . PHE A 1 418 ? 131.606 14.932 51.417 1.00 31.63 ? 418 PHE A CG 1 ATOM 3322 C CD1 . PHE A 1 418 ? 130.790 15.869 52.071 1.00 29.75 ? 418 PHE A CD1 1 ATOM 3323 C CD2 . PHE A 1 418 ? 131.000 13.931 50.627 1.00 27.44 ? 418 PHE A CD2 1 ATOM 3324 C CE1 . PHE A 1 418 ? 129.381 15.783 51.954 1.00 32.40 ? 418 PHE A CE1 1 ATOM 3325 C CE2 . PHE A 1 418 ? 129.592 13.849 50.516 1.00 28.61 ? 418 PHE A CE2 1 ATOM 3326 C CZ . PHE A 1 418 ? 128.788 14.746 51.185 1.00 25.99 ? 418 PHE A CZ 1 ATOM 3327 N N . TYR A 1 419 ? 132.369 18.261 50.469 1.00 33.82 ? 419 TYR A N 1 ATOM 3328 C CA . TYR A 1 419 ? 131.956 19.575 51.009 1.00 34.81 ? 419 TYR A CA 1 ATOM 3329 C C . TYR A 1 419 ? 130.526 19.540 51.520 1.00 36.34 ? 419 TYR A C 1 ATOM 3330 O O . TYR A 1 419 ? 129.689 18.730 51.053 1.00 34.65 ? 419 TYR A O 1 ATOM 3331 C CB . TYR A 1 419 ? 132.092 20.767 50.013 1.00 34.85 ? 419 TYR A CB 1 ATOM 3332 C CG . TYR A 1 419 ? 131.172 20.666 48.843 1.00 33.12 ? 419 TYR A CG 1 ATOM 3333 C CD1 . TYR A 1 419 ? 131.581 20.019 47.653 1.00 31.20 ? 419 TYR A CD1 1 ATOM 3334 C CD2 . TYR A 1 419 ? 129.873 21.163 48.936 1.00 32.44 ? 419 TYR A CD2 1 ATOM 3335 C CE1 . TYR A 1 419 ? 130.684 19.892 46.552 1.00 32.13 ? 419 TYR A CE1 1 ATOM 3336 C CE2 . TYR A 1 419 ? 128.984 21.063 47.872 1.00 34.23 ? 419 TYR A CE2 1 ATOM 3337 C CZ . TYR A 1 419 ? 129.384 20.414 46.696 1.00 34.26 ? 419 TYR A CZ 1 ATOM 3338 O OH . TYR A 1 419 ? 128.452 20.295 45.690 1.00 35.66 ? 419 TYR A OH 1 ATOM 3339 N N . TYR A 1 420 ? 130.253 20.444 52.472 1.00 36.81 ? 420 TYR A N 1 ATOM 3340 C CA . TYR A 1 420 ? 128.886 20.694 52.917 1.00 37.41 ? 420 TYR A CA 1 ATOM 3341 C C . TYR A 1 420 ? 128.603 22.193 52.671 1.00 37.69 ? 420 TYR A C 1 ATOM 3342 O O . TYR A 1 420 ? 129.151 23.061 53.362 1.00 36.47 ? 420 TYR A O 1 ATOM 3343 C CB . TYR A 1 420 ? 128.803 20.359 54.407 1.00 36.72 ? 420 TYR A CB 1 ATOM 3344 C CG . TYR A 1 420 ? 127.427 20.408 55.020 1.00 36.53 ? 420 TYR A CG 1 ATOM 3345 C CD1 . TYR A 1 420 ? 126.393 19.627 54.509 1.00 37.15 ? 420 TYR A CD1 1 ATOM 3346 C CD2 . TYR A 1 420 ? 127.162 21.216 56.128 1.00 34.70 ? 420 TYR A CD2 1 ATOM 3347 C CE1 . TYR A 1 420 ? 125.131 19.632 55.077 1.00 38.02 ? 420 TYR A CE1 1 ATOM 3348 C CE2 . TYR A 1 420 ? 125.925 21.218 56.700 1.00 37.07 ? 420 TYR A CE2 1 ATOM 3349 C CZ . TYR A 1 420 ? 124.905 20.416 56.175 1.00 37.99 ? 420 TYR A CZ 1 ATOM 3350 O OH . TYR A 1 420 ? 123.653 20.393 56.734 1.00 38.41 ? 420 TYR A OH 1 ATOM 3351 N N . PHE A 1 421 ? 127.763 22.485 51.674 1.00 38.45 ? 421 PHE A N 1 ATOM 3352 C CA . PHE A 1 421 ? 127.483 23.863 51.276 1.00 38.37 ? 421 PHE A CA 1 ATOM 3353 C C . PHE A 1 421 ? 126.373 24.426 52.135 1.00 38.71 ? 421 PHE A C 1 ATOM 3354 O O . PHE A 1 421 ? 125.225 23.972 52.108 1.00 38.25 ? 421 PHE A O 1 ATOM 3355 C CB . PHE A 1 421 ? 127.187 23.925 49.767 1.00 37.71 ? 421 PHE A CB 1 ATOM 3356 C CG . PHE A 1 421 ? 126.940 25.311 49.235 1.00 40.06 ? 421 PHE A CG 1 ATOM 3357 C CD1 . PHE A 1 421 ? 128.001 26.095 48.740 1.00 40.95 ? 421 PHE A CD1 1 ATOM 3358 C CD2 . PHE A 1 421 ? 125.625 25.806 49.130 1.00 39.60 ? 421 PHE A CD2 1 ATOM 3359 C CE1 . PHE A 1 421 ? 127.763 27.383 48.208 1.00 41.19 ? 421 PHE A CE1 1 ATOM 3360 C CE2 . PHE A 1 421 ? 125.386 27.062 48.581 1.00 41.58 ? 421 PHE A CE2 1 ATOM 3361 C CZ . PHE A 1 421 ? 126.444 27.866 48.123 1.00 38.12 ? 421 PHE A CZ 1 ATOM 3362 N N . GLU A 1 422 ? 126.723 25.426 52.936 1.00 39.90 ? 422 GLU A N 1 ATOM 3363 C CA . GLU A 1 422 ? 125.762 25.935 53.884 1.00 41.63 ? 422 GLU A CA 1 ATOM 3364 C C . GLU A 1 422 ? 125.494 27.426 53.712 1.00 41.96 ? 422 GLU A C 1 ATOM 3365 O O . GLU A 1 422 ? 125.124 28.086 54.671 1.00 41.61 ? 422 GLU A O 1 ATOM 3366 C CB . GLU A 1 422 ? 126.160 25.576 55.334 1.00 41.84 ? 422 GLU A CB 1 ATOM 3367 C CG . GLU A 1 422 ? 127.607 25.850 55.671 1.00 47.37 ? 422 GLU A CG 1 ATOM 3368 C CD . GLU A 1 422 ? 128.034 25.400 57.087 1.00 49.86 ? 422 GLU A CD 1 ATOM 3369 O OE1 . GLU A 1 422 ? 127.359 24.549 57.690 1.00 47.96 ? 422 GLU A OE1 1 ATOM 3370 O OE2 . GLU A 1 422 ? 129.082 25.908 57.575 1.00 53.55 ? 422 GLU A OE2 1 ATOM 3371 N N . HIS A 1 423 ? 125.643 27.962 52.499 1.00 41.43 ? 423 HIS A N 1 ATOM 3372 C CA . HIS A 1 423 ? 125.289 29.375 52.314 1.00 41.95 ? 423 HIS A CA 1 ATOM 3373 C C . HIS A 1 423 ? 123.969 29.583 51.544 1.00 41.52 ? 423 HIS A C 1 ATOM 3374 O O . HIS A 1 423 ? 123.808 29.064 50.471 1.00 40.88 ? 423 HIS A O 1 ATOM 3375 C CB . HIS A 1 423 ? 126.429 30.149 51.654 1.00 41.54 ? 423 HIS A CB 1 ATOM 3376 C CG . HIS A 1 423 ? 126.044 31.546 51.285 1.00 44.71 ? 423 HIS A CG 1 ATOM 3377 N ND1 . HIS A 1 423 ? 125.934 32.558 52.217 1.00 46.34 ? 423 HIS A ND1 1 ATOM 3378 C CD2 . HIS A 1 423 ? 125.694 32.093 50.092 1.00 45.81 ? 423 HIS A CD2 1 ATOM 3379 C CE1 . HIS A 1 423 ? 125.520 33.663 51.616 1.00 45.41 ? 423 HIS A CE1 1 ATOM 3380 N NE2 . HIS A 1 423 ? 125.394 33.413 50.324 1.00 47.23 ? 423 HIS A NE2 1 ATOM 3381 N N . ARG A 1 424 ? 123.029 30.324 52.109 1.00 42.31 ? 424 ARG A N 1 ATOM 3382 C CA . ARG A 1 424 ? 121.819 30.775 51.364 1.00 44.09 ? 424 ARG A CA 1 ATOM 3383 C C . ARG A 1 424 ? 122.068 32.062 50.551 1.00 45.15 ? 424 ARG A C 1 ATOM 3384 O O . ARG A 1 424 ? 122.490 33.066 51.112 1.00 44.34 ? 424 ARG A O 1 ATOM 3385 C CB . ARG A 1 424 ? 120.674 31.024 52.336 1.00 43.80 ? 424 ARG A CB 1 ATOM 3386 C CG . ARG A 1 424 ? 119.320 31.187 51.708 1.00 43.76 ? 424 ARG A CG 1 ATOM 3387 C CD . ARG A 1 424 ? 118.274 31.398 52.730 1.00 45.29 ? 424 ARG A CD 1 ATOM 3388 N NE . ARG A 1 424 ? 117.143 32.215 52.271 1.00 50.90 ? 424 ARG A NE 1 ATOM 3389 C CZ . ARG A 1 424 ? 115.966 31.737 51.846 1.00 53.22 ? 424 ARG A CZ 1 ATOM 3390 N NH1 . ARG A 1 424 ? 115.737 30.411 51.771 1.00 53.62 ? 424 ARG A NH1 1 ATOM 3391 N NH2 . ARG A 1 424 ? 115.008 32.590 51.474 1.00 51.34 ? 424 ARG A NH2 1 ATOM 3392 N N . SER A 1 425 ? 121.819 32.025 49.239 1.00 46.06 ? 425 SER A N 1 ATOM 3393 C CA . SER A 1 425 ? 121.881 33.224 48.400 1.00 47.99 ? 425 SER A CA 1 ATOM 3394 C C . SER A 1 425 ? 121.113 34.410 49.047 1.00 47.85 ? 425 SER A C 1 ATOM 3395 O O . SER A 1 425 ? 120.002 34.249 49.554 1.00 48.16 ? 425 SER A O 1 ATOM 3396 C CB . SER A 1 425 ? 121.311 32.876 47.030 1.00 49.08 ? 425 SER A CB 1 ATOM 3397 O OG . SER A 1 425 ? 121.760 33.762 46.025 1.00 53.01 ? 425 SER A OG 1 ATOM 3398 N N . SER A 1 426 ? 121.722 35.582 49.100 1.00 48.29 ? 426 SER A N 1 ATOM 3399 C CA . SER A 1 426 ? 120.983 36.807 49.488 1.00 48.81 ? 426 SER A CA 1 ATOM 3400 C C . SER A 1 426 ? 119.842 37.055 48.500 1.00 49.80 ? 426 SER A C 1 ATOM 3401 O O . SER A 1 426 ? 118.851 37.664 48.836 1.00 49.29 ? 426 SER A O 1 ATOM 3402 C CB . SER A 1 426 ? 121.905 38.029 49.517 1.00 48.77 ? 426 SER A CB 1 ATOM 3403 O OG . SER A 1 426 ? 122.625 38.172 48.305 1.00 46.13 ? 426 SER A OG 1 ATOM 3404 N N . LYS A 1 427 ? 120.002 36.548 47.278 1.00 50.88 ? 427 LYS A N 1 ATOM 3405 C CA . LYS A 1 427 ? 119.010 36.713 46.215 1.00 52.00 ? 427 LYS A CA 1 ATOM 3406 C C . LYS A 1 427 ? 117.938 35.593 46.107 1.00 51.75 ? 427 LYS A C 1 ATOM 3407 O O . LYS A 1 427 ? 117.038 35.686 45.256 1.00 52.90 ? 427 LYS A O 1 ATOM 3408 C CB . LYS A 1 427 ? 119.730 36.910 44.868 1.00 51.77 ? 427 LYS A CB 1 ATOM 3409 C CG . LYS A 1 427 ? 120.888 37.910 44.945 1.00 54.76 ? 427 LYS A CG 1 ATOM 3410 C CD . LYS A 1 427 ? 121.410 38.261 43.564 1.00 57.49 ? 427 LYS A CD 1 ATOM 3411 C CE . LYS A 1 427 ? 120.269 38.435 42.502 1.00 59.04 ? 427 LYS A CE 1 ATOM 3412 N NZ . LYS A 1 427 ? 120.820 38.406 41.099 1.00 59.93 ? 427 LYS A NZ 1 ATOM 3413 N N . LEU A 1 428 ? 118.002 34.556 46.950 1.00 50.61 ? 428 LEU A N 1 ATOM 3414 C CA . LEU A 1 428 ? 117.054 33.435 46.865 1.00 49.27 ? 428 LEU A CA 1 ATOM 3415 C C . LEU A 1 428 ? 115.586 33.916 46.899 1.00 48.06 ? 428 LEU A C 1 ATOM 3416 O O . LEU A 1 428 ? 115.190 34.620 47.842 1.00 48.69 ? 428 LEU A O 1 ATOM 3417 C CB . LEU A 1 428 ? 117.353 32.392 47.967 1.00 49.66 ? 428 LEU A CB 1 ATOM 3418 C CG . LEU A 1 428 ? 117.240 30.856 47.779 1.00 50.01 ? 428 LEU A CG 1 ATOM 3419 C CD1 . LEU A 1 428 ? 116.108 30.247 48.564 1.00 51.41 ? 428 LEU A CD1 1 ATOM 3420 C CD2 . LEU A 1 428 ? 117.123 30.437 46.360 1.00 52.02 ? 428 LEU A CD2 1 ATOM 3421 N N . PRO A 1 429 ? 114.787 33.577 45.883 1.00 46.11 ? 429 PRO A N 1 ATOM 3422 C CA . PRO A 1 429 ? 113.352 33.960 45.849 1.00 45.20 ? 429 PRO A CA 1 ATOM 3423 C C . PRO A 1 429 ? 112.385 33.058 46.662 1.00 44.70 ? 429 PRO A C 1 ATOM 3424 O O . PRO A 1 429 ? 111.263 33.463 46.954 1.00 44.90 ? 429 PRO A O 1 ATOM 3425 C CB . PRO A 1 429 ? 113.013 33.899 44.364 1.00 44.89 ? 429 PRO A CB 1 ATOM 3426 C CG . PRO A 1 429 ? 114.143 33.192 43.689 1.00 44.84 ? 429 PRO A CG 1 ATOM 3427 C CD . PRO A 1 429 ? 115.189 32.832 44.684 1.00 46.01 ? 429 PRO A CD 1 ATOM 3428 N N . TRP A 1 430 ? 112.817 31.855 47.034 1.00 43.47 ? 430 TRP A N 1 ATOM 3429 C CA . TRP A 1 430 ? 112.082 31.010 47.993 1.00 42.47 ? 430 TRP A CA 1 ATOM 3430 C C . TRP A 1 430 ? 112.150 31.530 49.446 1.00 43.06 ? 430 TRP A C 1 ATOM 3431 O O . TRP A 1 430 ? 113.073 32.267 49.801 1.00 42.35 ? 430 TRP A O 1 ATOM 3432 C CB . TRP A 1 430 ? 112.672 29.624 47.937 1.00 41.76 ? 430 TRP A CB 1 ATOM 3433 C CG . TRP A 1 430 ? 112.678 29.019 46.554 1.00 37.39 ? 430 TRP A CG 1 ATOM 3434 C CD1 . TRP A 1 430 ? 113.706 29.025 45.644 1.00 35.68 ? 430 TRP A CD1 1 ATOM 3435 C CD2 . TRP A 1 430 ? 111.602 28.325 45.939 1.00 34.37 ? 430 TRP A CD2 1 ATOM 3436 N NE1 . TRP A 1 430 ? 113.330 28.367 44.497 1.00 34.77 ? 430 TRP A NE1 1 ATOM 3437 C CE2 . TRP A 1 430 ? 112.049 27.896 44.661 1.00 34.36 ? 430 TRP A CE2 1 ATOM 3438 C CE3 . TRP A 1 430 ? 110.291 27.992 46.341 1.00 34.94 ? 430 TRP A CE3 1 ATOM 3439 C CZ2 . TRP A 1 430 ? 111.228 27.185 43.782 1.00 32.17 ? 430 TRP A CZ2 1 ATOM 3440 C CZ3 . TRP A 1 430 ? 109.494 27.233 45.478 1.00 31.69 ? 430 TRP A CZ3 1 ATOM 3441 C CH2 . TRP A 1 430 ? 109.953 26.877 44.204 1.00 34.59 ? 430 TRP A CH2 1 ATOM 3442 N N . PRO A 1 431 ? 111.185 31.181 50.296 1.00 42.61 ? 431 PRO A N 1 ATOM 3443 C CA . PRO A 1 431 ? 111.205 31.703 51.658 1.00 42.76 ? 431 PRO A CA 1 ATOM 3444 C C . PRO A 1 431 ? 112.394 31.220 52.541 1.00 44.99 ? 431 PRO A C 1 ATOM 3445 O O . PRO A 1 431 ? 113.165 30.295 52.143 1.00 46.16 ? 431 PRO A O 1 ATOM 3446 C CB . PRO A 1 431 ? 109.852 31.310 52.210 1.00 42.41 ? 431 PRO A CB 1 ATOM 3447 C CG . PRO A 1 431 ? 109.423 30.133 51.365 1.00 44.09 ? 431 PRO A CG 1 ATOM 3448 C CD . PRO A 1 431 ? 109.999 30.356 50.004 1.00 41.87 ? 431 PRO A CD 1 ATOM 3449 N N . GLU A 1 432 ? 112.548 31.844 53.709 1.00 45.00 ? 432 GLU A N 1 ATOM 3450 C CA . GLU A 1 432 ? 113.685 31.609 54.605 1.00 46.57 ? 432 GLU A CA 1 ATOM 3451 C C . GLU A 1 432 ? 113.719 30.226 55.169 1.00 46.31 ? 432 GLU A C 1 ATOM 3452 O O . GLU A 1 432 ? 114.791 29.675 55.371 1.00 47.10 ? 432 GLU A O 1 ATOM 3453 C CB . GLU A 1 432 ? 113.774 32.645 55.747 1.00 46.78 ? 432 GLU A CB 1 ATOM 3454 C CG . GLU A 1 432 ? 114.940 33.638 55.603 0.50 49.65 ? 432 GLU A CG 1 ATOM 3455 C CD . GLU A 1 432 ? 116.303 33.070 56.042 0.50 53.98 ? 432 GLU A CD 1 ATOM 3456 O OE1 . GLU A 1 432 ? 117.337 33.404 55.405 0.50 52.54 ? 432 GLU A OE1 1 ATOM 3457 O OE2 . GLU A 1 432 ? 116.359 32.277 57.027 0.50 56.86 ? 432 GLU A OE2 1 ATOM 3458 N N . TRP A 1 433 ? 112.545 29.669 55.394 1.00 46.67 ? 433 TRP A N 1 ATOM 3459 C CA . TRP A 1 433 ? 112.393 28.373 56.033 1.00 47.00 ? 433 TRP A CA 1 ATOM 3460 C C . TRP A 1 433 ? 112.931 27.283 55.120 1.00 47.00 ? 433 TRP A C 1 ATOM 3461 O O . TRP A 1 433 ? 113.279 26.223 55.600 1.00 46.77 ? 433 TRP A O 1 ATOM 3462 C CB . TRP A 1 433 ? 110.908 28.104 56.390 1.00 47.42 ? 433 TRP A CB 1 ATOM 3463 C CG . TRP A 1 433 ? 109.933 27.739 55.258 1.00 47.47 ? 433 TRP A CG 1 ATOM 3464 C CD1 . TRP A 1 433 ? 108.987 28.553 54.720 1.00 46.79 ? 433 TRP A CD1 1 ATOM 3465 C CD2 . TRP A 1 433 ? 109.762 26.447 54.598 1.00 47.84 ? 433 TRP A CD2 1 ATOM 3466 N NE1 . TRP A 1 433 ? 108.266 27.881 53.759 1.00 47.36 ? 433 TRP A NE1 1 ATOM 3467 C CE2 . TRP A 1 433 ? 108.718 26.592 53.661 1.00 45.77 ? 433 TRP A CE2 1 ATOM 3468 C CE3 . TRP A 1 433 ? 110.397 25.188 54.700 1.00 47.62 ? 433 TRP A CE3 1 ATOM 3469 C CZ2 . TRP A 1 433 ? 108.291 25.545 52.832 1.00 47.83 ? 433 TRP A CZ2 1 ATOM 3470 C CZ3 . TRP A 1 433 ? 109.987 24.143 53.859 1.00 46.14 ? 433 TRP A CZ3 1 ATOM 3471 C CH2 . TRP A 1 433 ? 108.945 24.329 52.931 1.00 47.65 ? 433 TRP A CH2 1 ATOM 3472 N N . MET A 1 434 ? 112.980 27.546 53.804 1.00 45.92 ? 434 MET A N 1 ATOM 3473 C CA . MET A 1 434 ? 113.514 26.555 52.861 1.00 44.82 ? 434 MET A CA 1 ATOM 3474 C C . MET A 1 434 ? 115.021 26.444 52.934 1.00 43.04 ? 434 MET A C 1 ATOM 3475 O O . MET A 1 434 ? 115.568 25.492 52.448 1.00 43.67 ? 434 MET A O 1 ATOM 3476 C CB . MET A 1 434 ? 113.046 26.791 51.424 1.00 44.44 ? 434 MET A CB 1 ATOM 3477 C CG . MET A 1 434 ? 111.503 26.856 51.272 1.00 45.54 ? 434 MET A CG 1 ATOM 3478 S SD . MET A 1 434 ? 111.111 26.559 49.561 1.00 45.95 ? 434 MET A SD 1 ATOM 3479 C CE . MET A 1 434 ? 109.434 26.055 49.662 1.00 48.04 ? 434 MET A CE 1 ATOM 3480 N N . GLY A 1 435 ? 115.665 27.435 53.520 1.00 42.08 ? 435 GLY A N 1 ATOM 3481 C CA . GLY A 1 435 ? 117.111 27.451 53.776 1.00 41.27 ? 435 GLY A CA 1 ATOM 3482 C C . GLY A 1 435 ? 118.039 27.459 52.577 1.00 41.18 ? 435 GLY A C 1 ATOM 3483 O O . GLY A 1 435 ? 117.798 28.207 51.618 1.00 40.78 ? 435 GLY A O 1 ATOM 3484 N N . VAL A 1 436 ? 119.103 26.627 52.664 1.00 40.09 ? 436 VAL A N 1 ATOM 3485 C CA . VAL A 1 436 ? 120.168 26.466 51.674 1.00 37.78 ? 436 VAL A CA 1 ATOM 3486 C C . VAL A 1 436 ? 119.697 25.375 50.732 1.00 39.16 ? 436 VAL A C 1 ATOM 3487 O O . VAL A 1 436 ? 119.969 24.164 50.916 1.00 39.76 ? 436 VAL A O 1 ATOM 3488 C CB . VAL A 1 436 ? 121.524 26.052 52.366 1.00 37.98 ? 436 VAL A CB 1 ATOM 3489 C CG1 . VAL A 1 436 ? 122.670 26.002 51.380 1.00 34.04 ? 436 VAL A CG1 1 ATOM 3490 C CG2 . VAL A 1 436 ? 121.852 26.988 53.534 1.00 35.55 ? 436 VAL A CG2 1 ATOM 3491 N N . MET A 1 437 ? 118.989 25.787 49.695 1.00 38.30 ? 437 MET A N 1 ATOM 3492 C CA . MET A 1 437 ? 118.231 24.818 48.940 1.00 37.85 ? 437 MET A CA 1 ATOM 3493 C C . MET A 1 437 ? 119.080 24.002 48.011 1.00 37.77 ? 437 MET A C 1 ATOM 3494 O O . MET A 1 437 ? 120.173 24.384 47.651 1.00 36.60 ? 437 MET A O 1 ATOM 3495 C CB . MET A 1 437 ? 117.103 25.489 48.164 1.00 37.26 ? 437 MET A CB 1 ATOM 3496 C CG . MET A 1 437 ? 115.960 25.883 49.031 1.00 38.10 ? 437 MET A CG 1 ATOM 3497 S SD . MET A 1 437 ? 114.838 26.971 48.136 1.00 42.08 ? 437 MET A SD 1 ATOM 3498 C CE . MET A 1 437 ? 114.112 25.853 46.941 1.00 33.27 ? 437 MET A CE 1 ATOM 3499 N N . HIS A 1 438 ? 118.521 22.864 47.637 1.00 38.50 ? 438 HIS A N 1 ATOM 3500 C CA . HIS A 1 438 ? 118.949 22.089 46.483 1.00 39.70 ? 438 HIS A CA 1 ATOM 3501 C C . HIS A 1 438 ? 119.031 23.012 45.249 1.00 39.88 ? 438 HIS A C 1 ATOM 3502 O O . HIS A 1 438 ? 118.081 23.749 44.990 1.00 39.86 ? 438 HIS A O 1 ATOM 3503 C CB . HIS A 1 438 ? 117.885 20.989 46.277 1.00 39.74 ? 438 HIS A CB 1 ATOM 3504 C CG . HIS A 1 438 ? 118.195 20.044 45.169 1.00 40.68 ? 438 HIS A CG 1 ATOM 3505 N ND1 . HIS A 1 438 ? 119.175 19.084 45.266 1.00 40.97 ? 438 HIS A ND1 1 ATOM 3506 C CD2 . HIS A 1 438 ? 117.644 19.900 43.944 1.00 42.07 ? 438 HIS A CD2 1 ATOM 3507 C CE1 . HIS A 1 438 ? 119.230 18.400 44.140 1.00 39.14 ? 438 HIS A CE1 1 ATOM 3508 N NE2 . HIS A 1 438 ? 118.310 18.876 43.322 1.00 44.07 ? 438 HIS A NE2 1 ATOM 3509 N N . GLY A 1 439 ? 120.178 23.005 44.554 1.00 39.81 ? 439 GLY A N 1 ATOM 3510 C CA . GLY A 1 439 ? 120.368 23.692 43.274 1.00 39.54 ? 439 GLY A CA 1 ATOM 3511 C C . GLY A 1 439 ? 121.043 25.033 43.460 1.00 39.77 ? 439 GLY A C 1 ATOM 3512 O O . GLY A 1 439 ? 121.453 25.655 42.496 1.00 40.27 ? 439 GLY A O 1 ATOM 3513 N N . TYR A 1 440 ? 121.151 25.503 44.693 1.00 39.29 ? 440 TYR A N 1 ATOM 3514 C CA . TYR A 1 440 ? 121.512 26.910 44.898 1.00 39.13 ? 440 TYR A CA 1 ATOM 3515 C C . TYR A 1 440 ? 122.979 27.134 45.306 1.00 39.35 ? 440 TYR A C 1 ATOM 3516 O O . TYR A 1 440 ? 123.363 28.234 45.695 1.00 39.93 ? 440 TYR A O 1 ATOM 3517 C CB . TYR A 1 440 ? 120.476 27.614 45.798 1.00 38.80 ? 440 TYR A CB 1 ATOM 3518 C CG . TYR A 1 440 ? 119.192 27.809 45.001 1.00 39.06 ? 440 TYR A CG 1 ATOM 3519 C CD1 . TYR A 1 440 ? 118.206 26.811 44.959 1.00 38.67 ? 440 TYR A CD1 1 ATOM 3520 C CD2 . TYR A 1 440 ? 119.023 28.922 44.191 1.00 39.00 ? 440 TYR A CD2 1 ATOM 3521 C CE1 . TYR A 1 440 ? 117.061 26.949 44.164 1.00 39.57 ? 440 TYR A CE1 1 ATOM 3522 C CE2 . TYR A 1 440 ? 117.873 29.069 43.382 1.00 36.51 ? 440 TYR A CE2 1 ATOM 3523 C CZ . TYR A 1 440 ? 116.897 28.118 43.394 1.00 39.81 ? 440 TYR A CZ 1 ATOM 3524 O OH . TYR A 1 440 ? 115.771 28.301 42.610 1.00 40.73 ? 440 TYR A OH 1 ATOM 3525 N N . GLU A 1 441 ? 123.781 26.071 45.188 1.00 39.14 ? 441 GLU A N 1 ATOM 3526 C CA . GLU A 1 441 ? 125.242 26.181 45.115 1.00 38.68 ? 441 GLU A CA 1 ATOM 3527 C C . GLU A 1 441 ? 125.716 26.451 43.684 1.00 38.51 ? 441 GLU A C 1 ATOM 3528 O O . GLU A 1 441 ? 126.826 26.950 43.491 1.00 38.52 ? 441 GLU A O 1 ATOM 3529 C CB . GLU A 1 441 ? 125.921 24.902 45.642 1.00 39.06 ? 441 GLU A CB 1 ATOM 3530 C CG . GLU A 1 441 ? 126.230 23.861 44.575 1.00 37.66 ? 441 GLU A CG 1 ATOM 3531 C CD . GLU A 1 441 ? 124.978 23.091 44.102 1.00 40.92 ? 441 GLU A CD 1 ATOM 3532 O OE1 . GLU A 1 441 ? 123.863 23.386 44.596 1.00 36.67 ? 441 GLU A OE1 1 ATOM 3533 O OE2 . GLU A 1 441 ? 125.117 22.186 43.237 1.00 38.87 ? 441 GLU A OE2 1 ATOM 3534 N N . ILE A 1 442 ? 124.890 26.114 42.696 1.00 37.02 ? 442 ILE A N 1 ATOM 3535 C CA . ILE A 1 442 ? 125.334 26.080 41.317 1.00 38.16 ? 442 ILE A CA 1 ATOM 3536 C C . ILE A 1 442 ? 125.837 27.455 40.894 1.00 38.89 ? 442 ILE A C 1 ATOM 3537 O O . ILE A 1 442 ? 126.888 27.580 40.271 1.00 39.38 ? 442 ILE A O 1 ATOM 3538 C CB . ILE A 1 442 ? 124.176 25.582 40.375 1.00 38.08 ? 442 ILE A CB 1 ATOM 3539 C CG1 . ILE A 1 442 ? 123.840 24.108 40.655 1.00 37.21 ? 442 ILE A CG1 1 ATOM 3540 C CG2 . ILE A 1 442 ? 124.547 25.790 38.901 1.00 40.17 ? 442 ILE A CG2 1 ATOM 3541 C CD1 . ILE A 1 442 ? 122.602 23.554 39.918 1.00 33.69 ? 442 ILE A CD1 1 ATOM 3542 N N . GLU A 1 443 ? 125.091 28.505 41.249 1.00 39.92 ? 443 GLU A N 1 ATOM 3543 C CA . GLU A 1 443 ? 125.449 29.856 40.795 1.00 39.73 ? 443 GLU A CA 1 ATOM 3544 C C . GLU A 1 443 ? 126.810 30.313 41.354 1.00 39.76 ? 443 GLU A C 1 ATOM 3545 O O . GLU A 1 443 ? 127.542 31.039 40.693 1.00 40.30 ? 443 GLU A O 1 ATOM 3546 C CB . GLU A 1 443 ? 124.346 30.844 41.133 1.00 39.40 ? 443 GLU A CB 1 ATOM 3547 C CG . GLU A 1 443 ? 123.974 30.876 42.596 1.00 40.06 ? 443 GLU A CG 1 ATOM 3548 C CD . GLU A 1 443 ? 122.577 31.430 42.794 1.00 42.51 ? 443 GLU A CD 1 ATOM 3549 O OE1 . GLU A 1 443 ? 121.569 30.667 42.694 1.00 41.44 ? 443 GLU A OE1 1 ATOM 3550 O OE2 . GLU A 1 443 ? 122.515 32.641 43.060 1.00 43.38 ? 443 GLU A OE2 1 ATOM 3551 N N . PHE A 1 444 ? 127.139 29.869 42.569 1.00 39.37 ? 444 PHE A N 1 ATOM 3552 C CA . PHE A 1 444 ? 128.483 30.007 43.132 1.00 38.12 ? 444 PHE A CA 1 ATOM 3553 C C . PHE A 1 444 ? 129.616 29.299 42.379 1.00 37.60 ? 444 PHE A C 1 ATOM 3554 O O . PHE A 1 444 ? 130.693 29.881 42.155 1.00 38.02 ? 444 PHE A O 1 ATOM 3555 C CB . PHE A 1 444 ? 128.439 29.604 44.588 1.00 37.51 ? 444 PHE A CB 1 ATOM 3556 C CG . PHE A 1 444 ? 127.723 30.603 45.391 1.00 37.59 ? 444 PHE A CG 1 ATOM 3557 C CD1 . PHE A 1 444 ? 126.326 30.636 45.390 1.00 35.07 ? 444 PHE A CD1 1 ATOM 3558 C CD2 . PHE A 1 444 ? 128.437 31.603 46.052 1.00 36.80 ? 444 PHE A CD2 1 ATOM 3559 C CE1 . PHE A 1 444 ? 125.663 31.622 46.098 1.00 37.48 ? 444 PHE A CE1 1 ATOM 3560 C CE2 . PHE A 1 444 ? 127.766 32.608 46.764 1.00 36.53 ? 444 PHE A CE2 1 ATOM 3561 C CZ . PHE A 1 444 ? 126.381 32.603 46.789 1.00 36.79 ? 444 PHE A CZ 1 ATOM 3562 N N . VAL A 1 445 ? 129.377 28.052 41.993 1.00 36.33 ? 445 VAL A N 1 ATOM 3563 C CA . VAL A 1 445 ? 130.342 27.260 41.213 1.00 35.43 ? 445 VAL A CA 1 ATOM 3564 C C . VAL A 1 445 ? 130.628 27.915 39.836 1.00 35.87 ? 445 VAL A C 1 ATOM 3565 O O . VAL A 1 445 ? 131.778 27.921 39.340 1.00 36.00 ? 445 VAL A O 1 ATOM 3566 C CB . VAL A 1 445 ? 129.802 25.771 41.037 1.00 35.43 ? 445 VAL A CB 1 ATOM 3567 C CG1 . VAL A 1 445 ? 130.581 24.998 39.991 1.00 30.31 ? 445 VAL A CG1 1 ATOM 3568 C CG2 . VAL A 1 445 ? 129.813 25.034 42.426 1.00 34.90 ? 445 VAL A CG2 1 ATOM 3569 N N . PHE A 1 446 ? 129.568 28.468 39.239 1.00 36.00 ? 446 PHE A N 1 ATOM 3570 C CA . PHE A 1 446 ? 129.654 29.066 37.927 1.00 36.36 ? 446 PHE A CA 1 ATOM 3571 C C . PHE A 1 446 ? 130.180 30.534 37.987 1.00 37.52 ? 446 PHE A C 1 ATOM 3572 O O . PHE A 1 446 ? 130.559 31.131 36.952 1.00 38.34 ? 446 PHE A O 1 ATOM 3573 C CB . PHE A 1 446 ? 128.319 28.848 37.186 1.00 34.83 ? 446 PHE A CB 1 ATOM 3574 C CG . PHE A 1 446 ? 128.255 27.539 36.403 1.00 32.95 ? 446 PHE A CG 1 ATOM 3575 C CD1 . PHE A 1 446 ? 127.645 26.398 36.949 1.00 31.77 ? 446 PHE A CD1 1 ATOM 3576 C CD2 . PHE A 1 446 ? 128.820 27.455 35.150 1.00 28.69 ? 446 PHE A CD2 1 ATOM 3577 C CE1 . PHE A 1 446 ? 127.608 25.183 36.258 1.00 31.95 ? 446 PHE A CE1 1 ATOM 3578 C CE2 . PHE A 1 446 ? 128.769 26.261 34.398 1.00 32.31 ? 446 PHE A CE2 1 ATOM 3579 C CZ . PHE A 1 446 ? 128.156 25.118 34.945 1.00 34.56 ? 446 PHE A CZ 1 ATOM 3580 N N . GLY A 1 447 ? 130.259 31.103 39.197 1.00 38.42 ? 447 GLY A N 1 ATOM 3581 C CA . GLY A 1 447 ? 130.888 32.435 39.369 1.00 39.37 ? 447 GLY A CA 1 ATOM 3582 C C . GLY A 1 447 ? 129.953 33.601 39.043 1.00 41.11 ? 447 GLY A C 1 ATOM 3583 O O . GLY A 1 447 ? 130.378 34.664 38.596 1.00 40.22 ? 447 GLY A O 1 ATOM 3584 N N . LEU A 1 448 ? 128.662 33.391 39.254 1.00 41.48 ? 448 LEU A N 1 ATOM 3585 C CA . LEU A 1 448 ? 127.726 34.463 39.083 1.00 43.86 ? 448 LEU A CA 1 ATOM 3586 C C . LEU A 1 448 ? 127.947 35.659 40.040 1.00 45.46 ? 448 LEU A C 1 ATOM 3587 O O . LEU A 1 448 ? 127.880 36.827 39.571 1.00 46.02 ? 448 LEU A O 1 ATOM 3588 C CB . LEU A 1 448 ? 126.284 33.958 39.122 1.00 43.18 ? 448 LEU A CB 1 ATOM 3589 C CG . LEU A 1 448 ? 125.642 33.550 37.784 1.00 42.80 ? 448 LEU A CG 1 ATOM 3590 C CD1 . LEU A 1 448 ? 126.409 32.429 37.062 1.00 39.53 ? 448 LEU A CD1 1 ATOM 3591 C CD2 . LEU A 1 448 ? 124.138 33.146 38.022 1.00 42.12 ? 448 LEU A CD2 1 ATOM 3592 N N . PRO A 1 449 ? 128.166 35.398 41.347 1.00 46.08 ? 449 PRO A N 1 ATOM 3593 C CA . PRO A 1 449 ? 128.477 36.475 42.304 1.00 46.72 ? 449 PRO A CA 1 ATOM 3594 C C . PRO A 1 449 ? 129.739 37.246 41.993 1.00 47.62 ? 449 PRO A C 1 ATOM 3595 O O . PRO A 1 449 ? 130.009 38.239 42.663 1.00 47.32 ? 449 PRO A O 1 ATOM 3596 C CB . PRO A 1 449 ? 128.614 35.744 43.636 1.00 45.48 ? 449 PRO A CB 1 ATOM 3597 C CG . PRO A 1 449 ? 127.752 34.573 43.438 1.00 46.92 ? 449 PRO A CG 1 ATOM 3598 C CD . PRO A 1 449 ? 128.062 34.100 42.038 1.00 45.01 ? 449 PRO A CD 1 ATOM 3599 N N . LEU A 1 450 ? 130.508 36.795 41.003 1.00 49.70 ? 450 LEU A N 1 ATOM 3600 C CA . LEU A 1 450 ? 131.677 37.562 40.526 1.00 50.86 ? 450 LEU A CA 1 ATOM 3601 C C . LEU A 1 450 ? 131.239 38.816 39.731 1.00 53.13 ? 450 LEU A C 1 ATOM 3602 O O . LEU A 1 450 ? 131.959 39.828 39.669 1.00 52.43 ? 450 LEU A O 1 ATOM 3603 C CB . LEU A 1 450 ? 132.680 36.688 39.767 1.00 49.12 ? 450 LEU A CB 1 ATOM 3604 C CG . LEU A 1 450 ? 133.141 35.421 40.544 1.00 49.32 ? 450 LEU A CG 1 ATOM 3605 C CD1 . LEU A 1 450 ? 134.319 34.655 39.877 1.00 44.22 ? 450 LEU A CD1 1 ATOM 3606 C CD2 . LEU A 1 450 ? 133.451 35.696 42.032 1.00 50.77 ? 450 LEU A CD2 1 ATOM 3607 N N . GLU A 1 451 ? 130.040 38.743 39.161 1.00 56.11 ? 451 GLU A N 1 ATOM 3608 C CA . GLU A 1 451 ? 129.474 39.859 38.443 1.00 59.08 ? 451 GLU A CA 1 ATOM 3609 C C . GLU A 1 451 ? 128.885 40.848 39.431 1.00 60.49 ? 451 GLU A C 1 ATOM 3610 O O . GLU A 1 451 ? 127.803 40.622 40.019 1.00 61.30 ? 451 GLU A O 1 ATOM 3611 C CB . GLU A 1 451 ? 128.450 39.402 37.412 1.00 59.69 ? 451 GLU A CB 1 ATOM 3612 C CG . GLU A 1 451 ? 127.793 40.538 36.627 1.00 64.22 ? 451 GLU A CG 1 ATOM 3613 C CD . GLU A 1 451 ? 128.765 41.267 35.694 1.00 68.39 ? 451 GLU A CD 1 ATOM 3614 O OE1 . GLU A 1 451 ? 129.495 42.204 36.148 1.00 70.87 ? 451 GLU A OE1 1 ATOM 3615 O OE2 . GLU A 1 451 ? 128.797 40.899 34.495 1.00 70.84 ? 451 GLU A OE2 1 ATOM 3616 N N . ARG A 1 452 ? 129.639 41.927 39.616 1.00 62.12 ? 452 ARG A N 1 ATOM 3617 C CA . ARG A 1 452 ? 129.295 43.043 40.499 1.00 64.67 ? 452 ARG A CA 1 ATOM 3618 C C . ARG A 1 452 ? 127.965 43.745 40.231 1.00 64.43 ? 452 ARG A C 1 ATOM 3619 O O . ARG A 1 452 ? 127.306 44.184 41.162 1.00 64.49 ? 452 ARG A O 1 ATOM 3620 C CB . ARG A 1 452 ? 130.420 44.085 40.505 1.00 65.25 ? 452 ARG A CB 1 ATOM 3621 C CG . ARG A 1 452 ? 131.321 43.929 41.691 1.00 70.00 ? 452 ARG A CG 1 ATOM 3622 C CD . ARG A 1 452 ? 130.553 44.134 42.986 1.00 76.98 ? 452 ARG A CD 1 ATOM 3623 N NE . ARG A 1 452 ? 130.928 43.201 44.048 1.00 80.17 ? 452 ARG A NE 1 ATOM 3624 C CZ . ARG A 1 452 ? 130.200 42.979 45.146 1.00 82.16 ? 452 ARG A CZ 1 ATOM 3625 N NH1 . ARG A 1 452 ? 129.030 43.595 45.346 1.00 81.48 ? 452 ARG A NH1 1 ATOM 3626 N NH2 . ARG A 1 452 ? 130.652 42.129 46.054 1.00 83.00 ? 452 ARG A NH2 1 ATOM 3627 N N . ARG A 1 453 ? 127.574 43.851 38.969 1.00 64.56 ? 453 ARG A N 1 ATOM 3628 C CA . ARG A 1 453 ? 126.324 44.531 38.645 1.00 64.76 ? 453 ARG A CA 1 ATOM 3629 C C . ARG A 1 453 ? 125.107 43.803 39.240 1.00 65.07 ? 453 ARG A C 1 ATOM 3630 O O . ARG A 1 453 ? 124.024 44.392 39.346 1.00 65.72 ? 453 ARG A O 1 ATOM 3631 C CB . ARG A 1 453 ? 126.176 44.703 37.117 1.00 65.11 ? 453 ARG A CB 1 ATOM 3632 C CG . ARG A 1 453 ? 127.411 45.272 36.375 0.30 63.78 ? 453 ARG A CG 1 ATOM 3633 C CD . ARG A 1 453 ? 127.879 46.665 36.817 0.30 62.87 ? 453 ARG A CD 1 ATOM 3634 N NE . ARG A 1 453 ? 126.774 47.609 37.003 0.30 61.96 ? 453 ARG A NE 1 ATOM 3635 C CZ . ARG A 1 453 ? 126.413 48.132 38.171 0.30 60.90 ? 453 ARG A CZ 1 ATOM 3636 N NH1 . ARG A 1 453 ? 127.073 47.830 39.282 0.30 60.53 ? 453 ARG A NH1 1 ATOM 3637 N NH2 . ARG A 1 453 ? 125.394 48.975 38.228 0.30 60.07 ? 453 ARG A NH2 1 ATOM 3638 N N . ASP A 1 454 ? 125.303 42.547 39.671 1.00 64.42 ? 454 ASP A N 1 ATOM 3639 C CA . ASP A 1 454 ? 124.198 41.609 39.895 1.00 63.68 ? 454 ASP A CA 1 ATOM 3640 C C . ASP A 1 454 ? 123.494 41.588 41.297 1.00 63.16 ? 454 ASP A C 1 ATOM 3641 O O . ASP A 1 454 ? 122.515 40.843 41.485 1.00 64.06 ? 454 ASP A O 1 ATOM 3642 C CB . ASP A 1 454 ? 124.638 40.198 39.460 1.00 64.12 ? 454 ASP A CB 1 ATOM 3643 C CG . ASP A 1 454 ? 123.477 39.343 38.933 0.50 64.24 ? 454 ASP A CG 1 ATOM 3644 O OD1 . ASP A 1 454 ? 122.321 39.827 38.900 0.50 64.46 ? 454 ASP A OD1 1 ATOM 3645 O OD2 . ASP A 1 454 ? 123.633 38.166 38.532 0.50 63.69 ? 454 ASP A OD2 1 ATOM 3646 N N . GLN A 1 455 ? 123.954 42.394 42.259 1.00 61.38 ? 455 GLN A N 1 ATOM 3647 C CA . GLN A 1 455 ? 123.272 42.503 43.589 1.00 59.59 ? 455 GLN A CA 1 ATOM 3648 C C . GLN A 1 455 ? 123.570 41.397 44.663 1.00 58.53 ? 455 GLN A C 1 ATOM 3649 O O . GLN A 1 455 ? 122.933 41.381 45.734 1.00 59.45 ? 455 GLN A O 1 ATOM 3650 C CB . GLN A 1 455 ? 121.750 42.735 43.444 0.30 59.46 ? 455 GLN A CB 1 ATOM 3651 C CG . GLN A 1 455 ? 121.324 44.209 43.300 0.30 58.87 ? 455 GLN A CG 1 ATOM 3652 C CD . GLN A 1 455 ? 121.483 44.748 41.887 0.30 57.69 ? 455 GLN A CD 1 ATOM 3653 O OE1 . GLN A 1 455 ? 122.268 45.669 41.655 0.30 55.62 ? 455 GLN A OE1 1 ATOM 3654 N NE2 . GLN A 1 455 ? 120.742 44.171 40.940 0.30 56.79 ? 455 GLN A NE2 1 ATOM 3655 N N . TYR A 1 456 ? 124.520 40.487 44.401 1.00 55.44 ? 456 TYR A N 1 ATOM 3656 C CA . TYR A 1 456 ? 125.080 39.662 45.488 1.00 52.79 ? 456 TYR A CA 1 ATOM 3657 C C . TYR A 1 456 ? 125.929 40.538 46.426 1.00 51.98 ? 456 TYR A C 1 ATOM 3658 O O . TYR A 1 456 ? 126.485 41.539 46.004 1.00 50.50 ? 456 TYR A O 1 ATOM 3659 C CB . TYR A 1 456 ? 125.946 38.515 44.946 1.00 51.34 ? 456 TYR A CB 1 ATOM 3660 C CG . TYR A 1 456 ? 125.218 37.473 44.114 1.00 46.78 ? 456 TYR A CG 1 ATOM 3661 C CD1 . TYR A 1 456 ? 125.153 37.584 42.725 1.00 43.57 ? 456 TYR A CD1 1 ATOM 3662 C CD2 . TYR A 1 456 ? 124.642 36.346 44.718 1.00 42.96 ? 456 TYR A CD2 1 ATOM 3663 C CE1 . TYR A 1 456 ? 124.521 36.590 41.932 1.00 43.31 ? 456 TYR A CE1 1 ATOM 3664 C CE2 . TYR A 1 456 ? 124.016 35.346 43.950 1.00 42.77 ? 456 TYR A CE2 1 ATOM 3665 C CZ . TYR A 1 456 ? 123.962 35.485 42.548 1.00 44.26 ? 456 TYR A CZ 1 ATOM 3666 O OH . TYR A 1 456 ? 123.356 34.529 41.789 1.00 40.30 ? 456 TYR A OH 1 ATOM 3667 N N . THR A 1 457 ? 126.031 40.139 47.690 1.00 51.03 ? 457 THR A N 1 ATOM 3668 C CA . THR A 1 457 ? 126.879 40.836 48.650 1.00 49.82 ? 457 THR A CA 1 ATOM 3669 C C . THR A 1 457 ? 128.350 40.587 48.379 1.00 50.18 ? 457 THR A C 1 ATOM 3670 O O . THR A 1 457 ? 128.742 39.755 47.549 1.00 50.13 ? 457 THR A O 1 ATOM 3671 C CB . THR A 1 457 ? 126.604 40.381 50.077 1.00 49.67 ? 457 THR A CB 1 ATOM 3672 O OG1 . THR A 1 457 ? 126.961 39.002 50.176 1.00 50.18 ? 457 THR A OG1 1 ATOM 3673 C CG2 . THR A 1 457 ? 125.125 40.423 50.423 1.00 47.01 ? 457 THR A CG2 1 ATOM 3674 N N . LYS A 1 458 ? 129.172 41.321 49.111 1.00 49.82 ? 458 LYS A N 1 ATOM 3675 C CA . LYS A 1 458 ? 130.607 41.226 48.955 1.00 50.08 ? 458 LYS A CA 1 ATOM 3676 C C . LYS A 1 458 ? 131.097 39.871 49.461 1.00 49.03 ? 458 LYS A C 1 ATOM 3677 O O . LYS A 1 458 ? 132.036 39.277 48.923 1.00 48.98 ? 458 LYS A O 1 ATOM 3678 C CB . LYS A 1 458 ? 131.294 42.400 49.720 1.00 50.13 ? 458 LYS A CB 1 ATOM 3679 C CG . LYS A 1 458 ? 132.793 42.407 49.624 1.00 50.98 ? 458 LYS A CG 1 ATOM 3680 C CD . LYS A 1 458 ? 133.187 42.996 48.295 1.00 58.38 ? 458 LYS A CD 1 ATOM 3681 C CE . LYS A 1 458 ? 134.543 42.489 47.832 1.00 61.54 ? 458 LYS A CE 1 ATOM 3682 N NZ . LYS A 1 458 ? 134.859 43.101 46.485 1.00 65.13 ? 458 LYS A NZ 1 ATOM 3683 N N . ALA A 1 459 ? 130.469 39.404 50.527 1.00 47.98 ? 459 ALA A N 1 ATOM 3684 C CA . ALA A 1 459 ? 130.899 38.187 51.104 1.00 47.67 ? 459 ALA A CA 1 ATOM 3685 C C . ALA A 1 459 ? 130.669 37.068 50.080 1.00 47.09 ? 459 ALA A C 1 ATOM 3686 O O . ALA A 1 459 ? 131.470 36.145 49.995 1.00 47.46 ? 459 ALA A O 1 ATOM 3687 C CB . ALA A 1 459 ? 130.185 37.938 52.448 1.00 47.76 ? 459 ALA A CB 1 ATOM 3688 N N . GLU A 1 460 ? 129.602 37.187 49.291 1.00 46.95 ? 460 GLU A N 1 ATOM 3689 C CA . GLU A 1 460 ? 129.220 36.208 48.247 1.00 46.30 ? 460 GLU A CA 1 ATOM 3690 C C . GLU A 1 460 ? 130.194 36.161 47.072 1.00 46.11 ? 460 GLU A C 1 ATOM 3691 O O . GLU A 1 460 ? 130.608 35.080 46.621 1.00 45.01 ? 460 GLU A O 1 ATOM 3692 C CB . GLU A 1 460 ? 127.794 36.476 47.772 1.00 45.82 ? 460 GLU A CB 1 ATOM 3693 C CG . GLU A 1 460 ? 126.807 35.994 48.812 1.00 46.63 ? 460 GLU A CG 1 ATOM 3694 C CD . GLU A 1 460 ? 125.356 36.228 48.465 1.00 48.97 ? 460 GLU A CD 1 ATOM 3695 O OE1 . GLU A 1 460 ? 125.063 37.248 47.824 1.00 48.31 ? 460 GLU A OE1 1 ATOM 3696 O OE2 . GLU A 1 460 ? 124.489 35.414 48.905 1.00 49.00 ? 460 GLU A OE2 1 ATOM 3697 N N . GLU A 1 461 ? 130.590 37.350 46.607 1.00 46.54 ? 461 GLU A N 1 ATOM 3698 C CA . GLU A 1 461 ? 131.634 37.491 45.611 1.00 45.85 ? 461 GLU A CA 1 ATOM 3699 C C . GLU A 1 461 ? 132.849 36.674 46.030 1.00 45.64 ? 461 GLU A C 1 ATOM 3700 O O . GLU A 1 461 ? 133.401 35.904 45.234 1.00 46.08 ? 461 GLU A O 1 ATOM 3701 C CB . GLU A 1 461 ? 132.016 38.971 45.446 1.00 45.95 ? 461 GLU A CB 1 ATOM 3702 C CG . GLU A 1 461 ? 133.123 39.166 44.404 1.00 49.58 ? 461 GLU A CG 1 ATOM 3703 C CD . GLU A 1 461 ? 133.762 40.576 44.352 1.00 53.69 ? 461 GLU A CD 1 ATOM 3704 O OE1 . GLU A 1 461 ? 135.004 40.620 44.215 1.00 55.92 ? 461 GLU A OE1 1 ATOM 3705 O OE2 . GLU A 1 461 ? 133.058 41.629 44.428 1.00 54.94 ? 461 GLU A OE2 1 ATOM 3706 N N . ILE A 1 462 ? 133.289 36.874 47.277 1.00 44.98 ? 462 ILE A N 1 ATOM 3707 C CA . ILE A 1 462 ? 134.476 36.209 47.786 1.00 44.69 ? 462 ILE A CA 1 ATOM 3708 C C . ILE A 1 462 ? 134.280 34.688 47.945 1.00 43.98 ? 462 ILE A C 1 ATOM 3709 O O . ILE A 1 462 ? 135.200 33.906 47.682 1.00 43.53 ? 462 ILE A O 1 ATOM 3710 C CB . ILE A 1 462 ? 134.939 36.847 49.146 1.00 45.79 ? 462 ILE A CB 1 ATOM 3711 C CG1 . ILE A 1 462 ? 135.244 38.343 48.994 1.00 48.18 ? 462 ILE A CG1 1 ATOM 3712 C CG2 . ILE A 1 462 ? 136.215 36.138 49.691 1.00 45.37 ? 462 ILE A CG2 1 ATOM 3713 C CD1 . ILE A 1 462 ? 136.527 38.617 48.125 1.00 49.90 ? 462 ILE A CD1 1 ATOM 3714 N N . LEU A 1 463 ? 133.085 34.276 48.380 1.00 43.32 ? 463 LEU A N 1 ATOM 3715 C CA . LEU A 1 463 ? 132.773 32.852 48.526 1.00 42.29 ? 463 LEU A CA 1 ATOM 3716 C C . LEU A 1 463 ? 132.856 32.182 47.170 1.00 41.58 ? 463 LEU A C 1 ATOM 3717 O O . LEU A 1 463 ? 133.457 31.141 47.038 1.00 42.03 ? 463 LEU A O 1 ATOM 3718 C CB . LEU A 1 463 ? 131.394 32.621 49.162 1.00 42.09 ? 463 LEU A CB 1 ATOM 3719 C CG . LEU A 1 463 ? 130.944 31.134 49.173 1.00 41.24 ? 463 LEU A CG 1 ATOM 3720 C CD1 . LEU A 1 463 ? 132.022 30.153 49.766 1.00 38.86 ? 463 LEU A CD1 1 ATOM 3721 C CD2 . LEU A 1 463 ? 129.603 31.016 49.861 1.00 39.48 ? 463 LEU A CD2 1 ATOM 3722 N N . SER A 1 464 ? 132.311 32.828 46.150 1.00 41.21 ? 464 SER A N 1 ATOM 3723 C CA . SER A 1 464 ? 132.282 32.242 44.816 1.00 41.31 ? 464 SER A CA 1 ATOM 3724 C C . SER A 1 464 ? 133.695 32.180 44.176 1.00 41.83 ? 464 SER A C 1 ATOM 3725 O O . SER A 1 464 ? 134.075 31.199 43.527 1.00 42.62 ? 464 SER A O 1 ATOM 3726 C CB . SER A 1 464 ? 131.254 33.015 43.954 1.00 40.96 ? 464 SER A CB 1 ATOM 3727 O OG . SER A 1 464 ? 131.295 32.624 42.599 1.00 38.73 ? 464 SER A OG 1 ATOM 3728 N N . ARG A 1 465 ? 134.482 33.221 44.394 1.00 42.43 ? 465 ARG A N 1 ATOM 3729 C CA . ARG A 1 465 ? 135.846 33.313 43.903 1.00 42.67 ? 465 ARG A CA 1 ATOM 3730 C C . ARG A 1 465 ? 136.695 32.162 44.416 1.00 42.58 ? 465 ARG A C 1 ATOM 3731 O O . ARG A 1 465 ? 137.463 31.538 43.674 1.00 43.44 ? 465 ARG A O 1 ATOM 3732 C CB . ARG A 1 465 ? 136.469 34.678 44.331 1.00 42.96 ? 465 ARG A CB 1 ATOM 3733 C CG . ARG A 1 465 ? 137.916 34.901 43.786 1.00 42.39 ? 465 ARG A CG 1 ATOM 3734 C CD . ARG A 1 465 ? 137.972 35.139 42.296 1.00 47.31 ? 465 ARG A CD 1 ATOM 3735 N NE . ARG A 1 465 ? 139.274 34.779 41.719 1.00 52.25 ? 465 ARG A NE 1 ATOM 3736 C CZ . ARG A 1 465 ? 139.664 33.546 41.330 1.00 51.82 ? 465 ARG A CZ 1 ATOM 3737 N NH1 . ARG A 1 465 ? 138.872 32.442 41.435 1.00 44.22 ? 465 ARG A NH1 1 ATOM 3738 N NH2 . ARG A 1 465 ? 140.898 33.431 40.842 1.00 52.71 ? 465 ARG A NH2 1 ATOM 3739 N N . SER A 1 466 ? 136.565 31.912 45.709 1.00 42.43 ? 466 SER A N 1 ATOM 3740 C CA . SER A 1 466 ? 137.191 30.794 46.369 1.00 42.59 ? 466 SER A CA 1 ATOM 3741 C C . SER A 1 466 ? 136.741 29.409 45.802 1.00 41.48 ? 466 SER A C 1 ATOM 3742 O O . SER A 1 466 ? 137.588 28.590 45.415 1.00 42.87 ? 466 SER A O 1 ATOM 3743 C CB . SER A 1 466 ? 136.922 30.933 47.868 1.00 42.39 ? 466 SER A CB 1 ATOM 3744 O OG . SER A 1 466 ? 137.571 29.879 48.566 1.00 48.89 ? 466 SER A OG 1 ATOM 3745 N N . ILE A 1 467 ? 135.429 29.178 45.675 1.00 41.00 ? 467 ILE A N 1 ATOM 3746 C CA . ILE A 1 467 ? 134.866 27.886 45.193 1.00 38.96 ? 467 ILE A CA 1 ATOM 3747 C C . ILE A 1 467 ? 135.346 27.646 43.753 1.00 38.89 ? 467 ILE A C 1 ATOM 3748 O O . ILE A 1 467 ? 135.757 26.558 43.363 1.00 38.35 ? 467 ILE A O 1 ATOM 3749 C CB . ILE A 1 467 ? 133.291 27.944 45.277 1.00 39.94 ? 467 ILE A CB 1 ATOM 3750 C CG1 . ILE A 1 467 ? 132.798 27.929 46.744 1.00 38.77 ? 467 ILE A CG1 1 ATOM 3751 C CG2 . ILE A 1 467 ? 132.585 26.850 44.379 1.00 38.04 ? 467 ILE A CG2 1 ATOM 3752 C CD1 . ILE A 1 467 ? 131.245 28.091 46.915 1.00 32.65 ? 467 ILE A CD1 1 ATOM 3753 N N . VAL A 1 468 ? 135.290 28.700 42.956 1.00 38.85 ? 468 VAL A N 1 ATOM 3754 C CA . VAL A 1 468 ? 135.789 28.660 41.587 1.00 38.33 ? 468 VAL A CA 1 ATOM 3755 C C . VAL A 1 468 ? 137.259 28.275 41.570 1.00 38.16 ? 468 VAL A C 1 ATOM 3756 O O . VAL A 1 468 ? 137.691 27.407 40.798 1.00 39.45 ? 468 VAL A O 1 ATOM 3757 C CB . VAL A 1 468 ? 135.518 30.069 40.862 1.00 38.65 ? 468 VAL A CB 1 ATOM 3758 C CG1 . VAL A 1 468 ? 136.270 30.172 39.560 1.00 36.18 ? 468 VAL A CG1 1 ATOM 3759 C CG2 . VAL A 1 468 ? 133.993 30.274 40.674 1.00 34.75 ? 468 VAL A CG2 1 ATOM 3760 N N . LYS A 1 469 ? 138.040 28.889 42.440 1.00 37.35 ? 469 LYS A N 1 ATOM 3761 C CA . LYS A 1 469 ? 139.448 28.529 42.479 1.00 36.34 ? 469 LYS A CA 1 ATOM 3762 C C . LYS A 1 469 ? 139.617 27.041 42.889 1.00 35.68 ? 469 LYS A C 1 ATOM 3763 O O . LYS A 1 469 ? 140.353 26.258 42.258 1.00 35.73 ? 469 LYS A O 1 ATOM 3764 C CB . LYS A 1 469 ? 140.191 29.485 43.425 1.00 35.37 ? 469 LYS A CB 1 ATOM 3765 C CG . LYS A 1 469 ? 141.659 29.227 43.550 1.00 35.30 ? 469 LYS A CG 1 ATOM 3766 C CD . LYS A 1 469 ? 142.349 29.069 42.205 1.00 37.09 ? 469 LYS A CD 1 ATOM 3767 C CE . LYS A 1 469 ? 142.832 30.381 41.659 1.00 39.68 ? 469 LYS A CE 1 ATOM 3768 N NZ . LYS A 1 469 ? 143.311 30.222 40.214 1.00 39.67 ? 469 LYS A NZ 1 ATOM 3769 N N . ARG A 1 470 ? 138.899 26.657 43.931 1.00 34.63 ? 470 ARG A N 1 ATOM 3770 C CA . ARG A 1 470 ? 138.972 25.268 44.408 1.00 34.73 ? 470 ARG A CA 1 ATOM 3771 C C . ARG A 1 470 ? 138.568 24.230 43.337 1.00 34.69 ? 470 ARG A C 1 ATOM 3772 O O . ARG A 1 470 ? 139.236 23.208 43.193 1.00 35.35 ? 470 ARG A O 1 ATOM 3773 C CB . ARG A 1 470 ? 138.136 25.099 45.678 1.00 33.09 ? 470 ARG A CB 1 ATOM 3774 C CG . ARG A 1 470 ? 138.728 25.775 46.909 1.00 32.42 ? 470 ARG A CG 1 ATOM 3775 C CD . ARG A 1 470 ? 137.906 25.462 48.123 1.00 33.97 ? 470 ARG A CD 1 ATOM 3776 N NE . ARG A 1 470 ? 138.285 26.190 49.319 1.00 36.19 ? 470 ARG A NE 1 ATOM 3777 C CZ . ARG A 1 470 ? 139.276 25.836 50.130 1.00 37.64 ? 470 ARG A CZ 1 ATOM 3778 N NH1 . ARG A 1 470 ? 139.508 26.550 51.219 1.00 39.57 ? 470 ARG A NH1 1 ATOM 3779 N NH2 . ARG A 1 470 ? 140.019 24.765 49.878 1.00 38.30 ? 470 ARG A NH2 1 ATOM 3780 N N . TRP A 1 471 ? 137.472 24.501 42.607 1.00 35.60 ? 471 TRP A N 1 ATOM 3781 C CA . TRP A 1 471 ? 136.960 23.615 41.529 1.00 34.04 ? 471 TRP A CA 1 ATOM 3782 C C . TRP A 1 471 ? 137.947 23.505 40.384 1.00 33.97 ? 471 TRP A C 1 ATOM 3783 O O . TRP A 1 471 ? 138.113 22.440 39.770 1.00 34.84 ? 471 TRP A O 1 ATOM 3784 C CB . TRP A 1 471 ? 135.595 24.150 41.038 1.00 32.61 ? 471 TRP A CB 1 ATOM 3785 C CG . TRP A 1 471 ? 134.306 23.458 41.660 1.00 32.78 ? 471 TRP A CG 1 ATOM 3786 C CD1 . TRP A 1 471 ? 133.262 22.883 40.955 1.00 33.52 ? 471 TRP A CD1 1 ATOM 3787 C CD2 . TRP A 1 471 ? 133.969 23.286 43.058 1.00 32.77 ? 471 TRP A CD2 1 ATOM 3788 N NE1 . TRP A 1 471 ? 132.314 22.386 41.826 1.00 36.51 ? 471 TRP A NE1 1 ATOM 3789 C CE2 . TRP A 1 471 ? 132.719 22.606 43.117 1.00 31.53 ? 471 TRP A CE2 1 ATOM 3790 C CE3 . TRP A 1 471 ? 134.589 23.649 44.268 1.00 30.95 ? 471 TRP A CE3 1 ATOM 3791 C CZ2 . TRP A 1 471 ? 132.078 22.310 44.317 1.00 32.85 ? 471 TRP A CZ2 1 ATOM 3792 C CZ3 . TRP A 1 471 ? 133.958 23.342 45.458 1.00 33.09 ? 471 TRP A CZ3 1 ATOM 3793 C CH2 . TRP A 1 471 ? 132.716 22.683 45.488 1.00 33.05 ? 471 TRP A CH2 1 ATOM 3794 N N . ALA A 1 472 ? 138.601 24.626 40.079 1.00 34.49 ? 472 ALA A N 1 ATOM 3795 C CA . ALA A 1 472 ? 139.528 24.712 38.967 1.00 35.39 ? 472 ALA A CA 1 ATOM 3796 C C . ALA A 1 472 ? 140.863 24.053 39.315 1.00 35.00 ? 472 ALA A C 1 ATOM 3797 O O . ALA A 1 472 ? 141.431 23.315 38.526 1.00 35.19 ? 472 ALA A O 1 ATOM 3798 C CB . ALA A 1 472 ? 139.723 26.195 38.555 1.00 37.37 ? 472 ALA A CB 1 ATOM 3799 N N . ASN A 1 473 ? 141.325 24.262 40.535 1.00 35.13 ? 473 ASN A N 1 ATOM 3800 C CA . ASN A 1 473 ? 142.462 23.481 41.032 1.00 33.77 ? 473 ASN A CA 1 ATOM 3801 C C . ASN A 1 473 ? 142.169 22.028 41.153 1.00 32.88 ? 473 ASN A C 1 ATOM 3802 O O . ASN A 1 473 ? 143.065 21.203 40.913 1.00 34.30 ? 473 ASN A O 1 ATOM 3803 C CB . ASN A 1 473 ? 142.943 24.009 42.382 1.00 33.90 ? 473 ASN A CB 1 ATOM 3804 C CG . ASN A 1 473 ? 143.770 25.285 42.237 1.00 36.34 ? 473 ASN A CG 1 ATOM 3805 O OD1 . ASN A 1 473 ? 144.138 25.708 41.106 1.00 35.29 ? 473 ASN A OD1 1 ATOM 3806 N ND2 . ASN A 1 473 ? 144.016 25.948 43.373 1.00 36.21 ? 473 ASN A ND2 1 ATOM 3807 N N . PHE A 1 474 ? 140.937 21.659 41.519 1.00 33.00 ? 474 PHE A N 1 ATOM 3808 C CA . PHE A 1 474 ? 140.599 20.218 41.450 1.00 32.68 ? 474 PHE A CA 1 ATOM 3809 C C . PHE A 1 474 ? 140.734 19.712 40.029 1.00 32.74 ? 474 PHE A C 1 ATOM 3810 O O . PHE A 1 474 ? 141.334 18.697 39.785 1.00 33.83 ? 474 PHE A O 1 ATOM 3811 C CB . PHE A 1 474 ? 139.189 19.894 41.969 1.00 32.77 ? 474 PHE A CB 1 ATOM 3812 C CG . PHE A 1 474 ? 138.894 18.416 41.946 1.00 32.67 ? 474 PHE A CG 1 ATOM 3813 C CD1 . PHE A 1 474 ? 139.522 17.562 42.879 1.00 30.00 ? 474 PHE A CD1 1 ATOM 3814 C CD2 . PHE A 1 474 ? 138.005 17.882 40.999 1.00 28.64 ? 474 PHE A CD2 1 ATOM 3815 C CE1 . PHE A 1 474 ? 139.263 16.217 42.874 1.00 28.67 ? 474 PHE A CE1 1 ATOM 3816 C CE2 . PHE A 1 474 ? 137.736 16.512 40.970 1.00 29.52 ? 474 PHE A CE2 1 ATOM 3817 C CZ . PHE A 1 474 ? 138.373 15.668 41.908 1.00 27.84 ? 474 PHE A CZ 1 ATOM 3818 N N . ALA A 1 475 ? 140.153 20.418 39.080 1.00 33.76 ? 475 ALA A N 1 ATOM 3819 C CA . ALA A 1 475 ? 140.174 19.982 37.685 1.00 34.74 ? 475 ALA A CA 1 ATOM 3820 C C . ALA A 1 475 ? 141.603 19.909 37.176 1.00 35.55 ? 475 ALA A C 1 ATOM 3821 O O . ALA A 1 475 ? 142.047 18.892 36.672 1.00 36.58 ? 475 ALA A O 1 ATOM 3822 C CB . ALA A 1 475 ? 139.343 20.944 36.829 1.00 33.53 ? 475 ALA A CB 1 ATOM 3823 N N . LYS A 1 476 ? 142.339 20.995 37.317 1.00 37.36 ? 476 LYS A N 1 ATOM 3824 C CA . LYS A 1 476 ? 143.695 21.010 36.783 1.00 38.81 ? 476 LYS A CA 1 ATOM 3825 C C . LYS A 1 476 ? 144.596 20.051 37.566 1.00 38.98 ? 476 LYS A C 1 ATOM 3826 O O . LYS A 1 476 ? 145.376 19.375 36.965 1.00 38.73 ? 476 LYS A O 1 ATOM 3827 C CB . LYS A 1 476 ? 144.284 22.424 36.793 1.00 38.84 ? 476 LYS A CB 1 ATOM 3828 C CG . LYS A 1 476 ? 143.506 23.473 35.941 1.00 39.45 ? 476 LYS A CG 1 ATOM 3829 C CD . LYS A 1 476 ? 143.980 24.879 36.326 1.00 40.70 ? 476 LYS A CD 1 ATOM 3830 C CE . LYS A 1 476 ? 143.199 25.936 35.564 1.00 43.27 ? 476 LYS A CE 1 ATOM 3831 N NZ . LYS A 1 476 ? 143.250 27.339 36.152 1.00 38.48 ? 476 LYS A NZ 1 ATOM 3832 N N . TYR A 1 477 ? 144.492 20.006 38.896 1.00 39.48 ? 477 TYR A N 1 ATOM 3833 C CA . TYR A 1 477 ? 145.558 19.357 39.685 1.00 40.56 ? 477 TYR A CA 1 ATOM 3834 C C . TYR A 1 477 ? 145.141 18.241 40.639 1.00 40.61 ? 477 TYR A C 1 ATOM 3835 O O . TYR A 1 477 ? 146.008 17.622 41.264 1.00 41.14 ? 477 TYR A O 1 ATOM 3836 C CB . TYR A 1 477 ? 146.292 20.395 40.531 1.00 40.17 ? 477 TYR A CB 1 ATOM 3837 C CG . TYR A 1 477 ? 146.643 21.629 39.778 1.00 40.14 ? 477 TYR A CG 1 ATOM 3838 C CD1 . TYR A 1 477 ? 146.181 22.882 40.198 1.00 39.48 ? 477 TYR A CD1 1 ATOM 3839 C CD2 . TYR A 1 477 ? 147.427 21.557 38.635 1.00 38.61 ? 477 TYR A CD2 1 ATOM 3840 C CE1 . TYR A 1 477 ? 146.499 24.034 39.469 1.00 40.79 ? 477 TYR A CE1 1 ATOM 3841 C CE2 . TYR A 1 477 ? 147.762 22.715 37.908 1.00 40.14 ? 477 TYR A CE2 1 ATOM 3842 C CZ . TYR A 1 477 ? 147.293 23.933 38.322 1.00 40.88 ? 477 TYR A CZ 1 ATOM 3843 O OH . TYR A 1 477 ? 147.643 25.052 37.600 1.00 42.44 ? 477 TYR A OH 1 ATOM 3844 N N . GLY A 1 478 ? 143.837 18.031 40.790 1.00 39.30 ? 478 GLY A N 1 ATOM 3845 C CA . GLY A 1 478 ? 143.318 16.891 41.525 1.00 38.46 ? 478 GLY A CA 1 ATOM 3846 C C . GLY A 1 478 ? 143.238 17.198 42.982 1.00 38.89 ? 478 GLY A C 1 ATOM 3847 O O . GLY A 1 478 ? 143.121 16.261 43.793 1.00 39.38 ? 478 GLY A O 1 ATOM 3848 N N . ASN A 1 479 ? 143.251 18.495 43.307 1.00 38.84 ? 479 ASN A N 1 ATOM 3849 C CA . ASN A 1 479 ? 143.382 18.990 44.674 1.00 39.89 ? 479 ASN A CA 1 ATOM 3850 C C . ASN A 1 479 ? 142.653 20.314 44.823 1.00 39.85 ? 479 ASN A C 1 ATOM 3851 O O . ASN A 1 479 ? 143.147 21.335 44.331 1.00 40.90 ? 479 ASN A O 1 ATOM 3852 C CB . ASN A 1 479 ? 144.862 19.200 44.997 1.00 40.39 ? 479 ASN A CB 1 ATOM 3853 C CG . ASN A 1 479 ? 145.228 18.821 46.447 1.00 42.41 ? 479 ASN A CG 1 ATOM 3854 O OD1 . ASN A 1 479 ? 144.409 18.946 47.371 1.00 44.73 ? 479 ASN A OD1 1 ATOM 3855 N ND2 . ASN A 1 479 ? 146.475 18.375 46.643 1.00 42.22 ? 479 ASN A ND2 1 ATOM 3856 N N . PRO A 1 480 ? 141.496 20.307 45.507 1.00 39.30 ? 480 PRO A N 1 ATOM 3857 C CA . PRO A 1 480 ? 140.616 21.463 45.561 1.00 39.44 ? 480 PRO A CA 1 ATOM 3858 C C . PRO A 1 480 ? 141.098 22.500 46.584 1.00 39.05 ? 480 PRO A C 1 ATOM 3859 O O . PRO A 1 480 ? 140.329 22.939 47.440 1.00 38.75 ? 480 PRO A O 1 ATOM 3860 C CB . PRO A 1 480 ? 139.271 20.844 46.003 1.00 40.48 ? 480 PRO A CB 1 ATOM 3861 C CG . PRO A 1 480 ? 139.688 19.682 46.919 1.00 38.05 ? 480 PRO A CG 1 ATOM 3862 C CD . PRO A 1 480 ? 140.950 19.181 46.287 1.00 39.07 ? 480 PRO A CD 1 ATOM 3863 N N . GLN A 1 481 ? 142.362 22.901 46.485 1.00 39.49 ? 481 GLN A N 1 ATOM 3864 C CA . GLN A 1 481 ? 142.927 23.827 47.471 1.00 39.42 ? 481 GLN A CA 1 ATOM 3865 C C . GLN A 1 481 ? 142.804 25.195 46.899 1.00 39.87 ? 481 GLN A C 1 ATOM 3866 O O . GLN A 1 481 ? 142.795 25.364 45.676 1.00 39.60 ? 481 GLN A O 1 ATOM 3867 C CB . GLN A 1 481 ? 144.422 23.521 47.794 1.00 37.99 ? 481 GLN A CB 1 ATOM 3868 C CG . GLN A 1 481 ? 144.744 22.093 48.305 1.00 35.21 ? 481 GLN A CG 1 ATOM 3869 C CD . GLN A 1 481 ? 143.818 21.594 49.408 1.00 34.78 ? 481 GLN A CD 1 ATOM 3870 O OE1 . GLN A 1 481 ? 143.328 22.379 50.224 1.00 36.03 ? 481 GLN A OE1 1 ATOM 3871 N NE2 . GLN A 1 481 ? 143.518 20.295 49.387 1.00 32.91 ? 481 GLN A NE2 1 ATOM 3872 N N . GLU A 1 482 ? 142.693 26.165 47.788 1.00 41.01 ? 482 GLU A N 1 ATOM 3873 C CA . GLU A 1 482 ? 142.929 27.561 47.471 1.00 44.00 ? 482 GLU A CA 1 ATOM 3874 C C . GLU A 1 482 ? 144.235 27.884 48.234 1.00 45.08 ? 482 GLU A C 1 ATOM 3875 O O . GLU A 1 482 ? 144.232 27.934 49.471 1.00 45.67 ? 482 GLU A O 1 ATOM 3876 C CB . GLU A 1 482 ? 141.766 28.430 47.928 1.00 42.99 ? 482 GLU A CB 1 ATOM 3877 C CG . GLU A 1 482 ? 141.810 29.839 47.336 1.00 48.17 ? 482 GLU A CG 1 ATOM 3878 C CD . GLU A 1 482 ? 143.004 30.682 47.811 1.00 51.86 ? 482 GLU A CD 1 ATOM 3879 O OE1 . GLU A 1 482 ? 143.627 31.380 46.976 1.00 51.34 ? 482 GLU A OE1 1 ATOM 3880 O OE2 . GLU A 1 482 ? 143.338 30.638 49.021 1.00 53.60 ? 482 GLU A OE2 1 ATOM 3881 N N . THR A 1 483 ? 145.356 28.014 47.516 1.00 46.11 ? 483 THR A N 1 ATOM 3882 C CA . THR A 1 483 ? 146.695 28.053 48.163 1.00 47.55 ? 483 THR A CA 1 ATOM 3883 C C . THR A 1 483 ? 147.252 29.453 48.555 1.00 48.85 ? 483 THR A C 1 ATOM 3884 O O . THR A 1 483 ? 148.204 29.535 49.299 1.00 48.24 ? 483 THR A O 1 ATOM 3885 C CB . THR A 1 483 ? 147.732 27.379 47.270 1.00 46.91 ? 483 THR A CB 1 ATOM 3886 O OG1 . THR A 1 483 ? 147.645 27.960 45.952 1.00 48.46 ? 483 THR A OG1 1 ATOM 3887 C CG2 . THR A 1 483 ? 147.404 25.936 47.061 1.00 47.08 ? 483 THR A CG2 1 ATOM 3888 N N . GLN A 1 484 ? 146.654 30.532 48.060 1.00 50.86 ? 484 GLN A N 1 ATOM 3889 C CA . GLN A 1 484 ? 147.272 31.845 48.136 1.00 52.95 ? 484 GLN A CA 1 ATOM 3890 C C . GLN A 1 484 ? 146.765 32.740 49.257 1.00 53.97 ? 484 GLN A C 1 ATOM 3891 O O . GLN A 1 484 ? 147.473 33.645 49.705 1.00 53.17 ? 484 GLN A O 1 ATOM 3892 C CB . GLN A 1 484 ? 147.062 32.587 46.821 1.00 52.98 ? 484 GLN A CB 1 ATOM 3893 C CG . GLN A 1 484 ? 147.792 31.971 45.657 1.00 56.14 ? 484 GLN A CG 1 ATOM 3894 C CD . GLN A 1 484 ? 147.585 32.739 44.384 1.00 61.46 ? 484 GLN A CD 1 ATOM 3895 O OE1 . GLN A 1 484 ? 146.459 33.226 44.077 1.00 61.25 ? 484 GLN A OE1 1 ATOM 3896 N NE2 . GLN A 1 484 ? 148.673 32.872 43.619 1.00 64.39 ? 484 GLN A NE2 1 ATOM 3897 N N . ASN A 1 485 ? 145.524 32.536 49.676 1.00 55.26 ? 485 ASN A N 1 ATOM 3898 C CA . ASN A 1 485 ? 144.921 33.502 50.591 1.00 56.77 ? 485 ASN A CA 1 ATOM 3899 C C . ASN A 1 485 ? 144.744 32.995 52.032 1.00 57.32 ? 485 ASN A C 1 ATOM 3900 O O . ASN A 1 485 ? 143.736 33.317 52.692 1.00 58.23 ? 485 ASN A O 1 ATOM 3901 C CB . ASN A 1 485 ? 143.608 34.039 50.012 1.00 57.10 ? 485 ASN A CB 1 ATOM 3902 C CG . ASN A 1 485 ? 143.802 34.923 48.746 1.00 60.68 ? 485 ASN A CG 1 ATOM 3903 O OD1 . ASN A 1 485 ? 144.896 35.045 48.189 1.00 62.92 ? 485 ASN A OD1 1 ATOM 3904 N ND2 . ASN A 1 485 ? 142.709 35.531 48.303 1.00 66.34 ? 485 ASN A ND2 1 ATOM 3905 N N . GLN A 1 486 ? 145.737 32.247 52.540 1.00 57.61 ? 486 GLN A N 1 ATOM 3906 C CA . GLN A 1 486 ? 145.657 31.624 53.878 1.00 57.84 ? 486 GLN A CA 1 ATOM 3907 C C . GLN A 1 486 ? 144.248 31.037 54.105 1.00 57.98 ? 486 GLN A C 1 ATOM 3908 O O . GLN A 1 486 ? 143.468 31.521 54.945 1.00 58.06 ? 486 GLN A O 1 ATOM 3909 C CB . GLN A 1 486 ? 145.988 32.613 55.019 1.00 58.38 ? 486 GLN A CB 1 ATOM 3910 C CG . GLN A 1 486 ? 146.880 33.815 54.656 0.50 58.60 ? 486 GLN A CG 1 ATOM 3911 C CD . GLN A 1 486 ? 146.489 35.057 55.447 0.50 58.83 ? 486 GLN A CD 1 ATOM 3912 O OE1 . GLN A 1 486 ? 146.106 36.071 54.870 0.50 58.04 ? 486 GLN A OE1 1 ATOM 3913 N NE2 . GLN A 1 486 ? 146.556 34.966 56.773 0.50 59.68 ? 486 GLN A NE2 1 ATOM 3914 N N . SER A 1 487 ? 143.928 30.020 53.316 1.00 56.69 ? 487 SER A N 1 ATOM 3915 C CA . SER A 1 487 ? 142.649 29.364 53.372 1.00 55.35 ? 487 SER A CA 1 ATOM 3916 C C . SER A 1 487 ? 142.819 28.034 54.037 1.00 54.21 ? 487 SER A C 1 ATOM 3917 O O . SER A 1 487 ? 143.925 27.484 54.071 1.00 53.94 ? 487 SER A O 1 ATOM 3918 C CB . SER A 1 487 ? 142.101 29.144 51.964 1.00 55.33 ? 487 SER A CB 1 ATOM 3919 O OG . SER A 1 487 ? 141.670 30.387 51.464 1.00 57.29 ? 487 SER A OG 1 ATOM 3920 N N . THR A 1 488 ? 141.702 27.533 54.564 1.00 53.16 ? 488 THR A N 1 ATOM 3921 C CA . THR A 1 488 ? 141.611 26.233 55.205 1.00 51.59 ? 488 THR A CA 1 ATOM 3922 C C . THR A 1 488 ? 141.969 25.207 54.145 1.00 50.72 ? 488 THR A C 1 ATOM 3923 O O . THR A 1 488 ? 141.493 25.294 53.000 1.00 50.91 ? 488 THR A O 1 ATOM 3924 C CB . THR A 1 488 ? 140.160 26.031 55.703 1.00 51.81 ? 488 THR A CB 1 ATOM 3925 O OG1 . THR A 1 488 ? 139.825 27.088 56.616 1.00 53.15 ? 488 THR A OG1 1 ATOM 3926 C CG2 . THR A 1 488 ? 140.012 24.764 56.559 1.00 52.24 ? 488 THR A CG2 1 ATOM 3927 N N . SER A 1 489 ? 142.857 24.290 54.501 1.00 49.39 ? 489 SER A N 1 ATOM 3928 C CA . SER A 1 489 ? 143.234 23.212 53.621 1.00 48.89 ? 489 SER A CA 1 ATOM 3929 C C . SER A 1 489 ? 142.072 22.220 53.655 1.00 47.79 ? 489 SER A C 1 ATOM 3930 O O . SER A 1 489 ? 141.391 22.076 54.684 1.00 47.77 ? 489 SER A O 1 ATOM 3931 C CB . SER A 1 489 ? 144.518 22.553 54.103 1.00 49.72 ? 489 SER A CB 1 ATOM 3932 O OG . SER A 1 489 ? 145.240 22.065 52.976 1.00 54.27 ? 489 SER A OG 1 ATOM 3933 N N . TRP A 1 490 ? 141.788 21.620 52.508 1.00 44.94 ? 490 TRP A N 1 ATOM 3934 C CA . TRP A 1 490 ? 140.684 20.742 52.389 1.00 42.58 ? 490 TRP A CA 1 ATOM 3935 C C . TRP A 1 490 ? 141.265 19.335 52.513 1.00 40.98 ? 490 TRP A C 1 ATOM 3936 O O . TRP A 1 490 ? 142.005 18.931 51.662 1.00 38.37 ? 490 TRP A O 1 ATOM 3937 C CB . TRP A 1 490 ? 140.034 20.929 51.023 1.00 41.86 ? 490 TRP A CB 1 ATOM 3938 C CG . TRP A 1 490 ? 138.722 20.226 50.852 1.00 41.57 ? 490 TRP A CG 1 ATOM 3939 C CD1 . TRP A 1 490 ? 138.238 19.111 51.556 1.00 39.88 ? 490 TRP A CD1 1 ATOM 3940 C CD2 . TRP A 1 490 ? 137.698 20.571 49.905 1.00 39.16 ? 490 TRP A CD2 1 ATOM 3941 N NE1 . TRP A 1 490 ? 136.992 18.768 51.080 1.00 37.42 ? 490 TRP A NE1 1 ATOM 3942 C CE2 . TRP A 1 490 ? 136.643 19.630 50.059 1.00 36.57 ? 490 TRP A CE2 1 ATOM 3943 C CE3 . TRP A 1 490 ? 137.570 21.579 48.924 1.00 37.98 ? 490 TRP A CE3 1 ATOM 3944 C CZ2 . TRP A 1 490 ? 135.476 19.675 49.274 1.00 35.74 ? 490 TRP A CZ2 1 ATOM 3945 C CZ3 . TRP A 1 490 ? 136.404 21.616 48.129 1.00 37.89 ? 490 TRP A CZ3 1 ATOM 3946 C CH2 . TRP A 1 490 ? 135.390 20.655 48.309 1.00 37.72 ? 490 TRP A CH2 1 ATOM 3947 N N . PRO A 1 491 ? 140.957 18.611 53.592 1.00 41.59 ? 491 PRO A N 1 ATOM 3948 C CA . PRO A 1 491 ? 141.533 17.287 53.798 1.00 41.65 ? 491 PRO A CA 1 ATOM 3949 C C . PRO A 1 491 ? 140.876 16.244 52.938 1.00 41.94 ? 491 PRO A C 1 ATOM 3950 O O . PRO A 1 491 ? 139.712 16.364 52.575 1.00 43.17 ? 491 PRO A O 1 ATOM 3951 C CB . PRO A 1 491 ? 141.262 17.006 55.284 1.00 42.63 ? 491 PRO A CB 1 ATOM 3952 C CG . PRO A 1 491 ? 140.047 17.786 55.614 1.00 42.37 ? 491 PRO A CG 1 ATOM 3953 C CD . PRO A 1 491 ? 140.083 19.014 54.717 1.00 41.70 ? 491 PRO A CD 1 ATOM 3954 N N . VAL A 1 492 ? 141.645 15.242 52.563 1.00 41.63 ? 492 VAL A N 1 ATOM 3955 C CA . VAL A 1 492 ? 141.100 14.096 51.903 1.00 41.64 ? 492 VAL A CA 1 ATOM 3956 C C . VAL A 1 492 ? 140.024 13.469 52.859 1.00 42.31 ? 492 VAL A C 1 ATOM 3957 O O . VAL A 1 492 ? 140.161 13.489 54.102 1.00 42.13 ? 492 VAL A O 1 ATOM 3958 C CB . VAL A 1 492 ? 142.266 13.167 51.454 1.00 41.80 ? 492 VAL A CB 1 ATOM 3959 C CG1 . VAL A 1 492 ? 141.794 11.878 50.980 1.00 44.70 ? 492 VAL A CG1 1 ATOM 3960 C CG2 . VAL A 1 492 ? 143.095 13.807 50.327 1.00 40.71 ? 492 VAL A CG2 1 ATOM 3961 N N . PHE A 1 493 ? 138.927 13.004 52.264 1.00 41.79 ? 493 PHE A N 1 ATOM 3962 C CA . PHE A 1 493 ? 137.912 12.154 52.921 1.00 42.42 ? 493 PHE A CA 1 ATOM 3963 C C . PHE A 1 493 ? 138.369 10.687 52.895 1.00 43.08 ? 493 PHE A C 1 ATOM 3964 O O . PHE A 1 493 ? 138.756 10.176 51.855 1.00 44.19 ? 493 PHE A O 1 ATOM 3965 C CB . PHE A 1 493 ? 136.563 12.321 52.176 1.00 41.37 ? 493 PHE A CB 1 ATOM 3966 C CG . PHE A 1 493 ? 135.392 11.611 52.803 1.00 41.16 ? 493 PHE A CG 1 ATOM 3967 C CD1 . PHE A 1 493 ? 135.170 10.266 52.577 1.00 40.98 ? 493 PHE A CD1 1 ATOM 3968 C CD2 . PHE A 1 493 ? 134.459 12.320 53.557 1.00 42.24 ? 493 PHE A CD2 1 ATOM 3969 C CE1 . PHE A 1 493 ? 134.074 9.610 53.139 1.00 41.91 ? 493 PHE A CE1 1 ATOM 3970 C CE2 . PHE A 1 493 ? 133.350 11.679 54.103 1.00 42.40 ? 493 PHE A CE2 1 ATOM 3971 C CZ . PHE A 1 493 ? 133.173 10.325 53.908 1.00 41.91 ? 493 PHE A CZ 1 ATOM 3972 N N . LYS A 1 494 ? 138.362 10.043 54.055 1.00 44.42 ? 494 LYS A N 1 ATOM 3973 C CA . LYS A 1 494 ? 138.826 8.662 54.252 1.00 46.08 ? 494 LYS A CA 1 ATOM 3974 C C . LYS A 1 494 ? 137.735 8.021 55.074 1.00 47.17 ? 494 LYS A C 1 ATOM 3975 O O . LYS A 1 494 ? 137.174 8.711 55.941 1.00 46.75 ? 494 LYS A O 1 ATOM 3976 C CB . LYS A 1 494 ? 140.118 8.647 55.062 1.00 45.68 ? 494 LYS A CB 1 ATOM 3977 C CG . LYS A 1 494 ? 141.398 9.000 54.320 1.00 47.45 ? 494 LYS A CG 1 ATOM 3978 C CD . LYS A 1 494 ? 142.425 9.593 55.314 1.00 51.92 ? 494 LYS A CD 1 ATOM 3979 C CE . LYS A 1 494 ? 143.882 9.597 54.801 1.00 54.91 ? 494 LYS A CE 1 ATOM 3980 N NZ . LYS A 1 494 ? 144.562 10.950 54.950 1.00 56.62 ? 494 LYS A NZ 1 ATOM 3981 N N . SER A 1 495 ? 137.398 6.744 54.838 1.00 48.59 ? 495 SER A N 1 ATOM 3982 C CA . SER A 1 495 ? 136.196 6.200 55.535 1.00 50.12 ? 495 SER A CA 1 ATOM 3983 C C . SER A 1 495 ? 136.299 5.979 57.059 1.00 49.66 ? 495 SER A C 1 ATOM 3984 O O . SER A 1 495 ? 135.259 5.848 57.738 1.00 50.16 ? 495 SER A O 1 ATOM 3985 C CB . SER A 1 495 ? 135.582 4.982 54.841 1.00 50.50 ? 495 SER A CB 1 ATOM 3986 O OG . SER A 1 495 ? 136.526 3.935 54.853 1.00 54.62 ? 495 SER A OG 1 ATOM 3987 N N . THR A 1 496 ? 137.513 6.011 57.598 1.00 49.52 ? 496 THR A N 1 ATOM 3988 C CA . THR A 1 496 ? 137.703 6.068 59.048 1.00 50.07 ? 496 THR A CA 1 ATOM 3989 C C . THR A 1 496 ? 137.291 7.471 59.578 1.00 48.56 ? 496 THR A C 1 ATOM 3990 O O . THR A 1 496 ? 136.285 7.627 60.290 1.00 47.97 ? 496 THR A O 1 ATOM 3991 C CB . THR A 1 496 ? 139.201 5.738 59.445 1.00 51.27 ? 496 THR A CB 1 ATOM 3992 O OG1 . THR A 1 496 ? 140.111 6.502 58.613 1.00 55.68 ? 496 THR A OG1 1 ATOM 3993 C CG2 . THR A 1 496 ? 139.587 4.275 59.115 1.00 52.70 ? 496 THR A CG2 1 ATOM 3994 N N . GLU A 1 497 ? 138.040 8.503 59.207 1.00 47.18 ? 497 GLU A N 1 ATOM 3995 C CA . GLU A 1 497 ? 137.749 9.822 59.761 1.00 46.13 ? 497 GLU A CA 1 ATOM 3996 C C . GLU A 1 497 ? 136.608 10.621 59.163 1.00 43.48 ? 497 GLU A C 1 ATOM 3997 O O . GLU A 1 497 ? 135.922 11.357 59.890 1.00 41.92 ? 497 GLU A O 1 ATOM 3998 C CB . GLU A 1 497 ? 139.001 10.642 59.826 1.00 47.12 ? 497 GLU A CB 1 ATOM 3999 C CG . GLU A 1 497 ? 139.913 10.058 60.861 1.00 52.54 ? 497 GLU A CG 1 ATOM 4000 C CD . GLU A 1 497 ? 141.303 9.965 60.340 1.00 59.45 ? 497 GLU A CD 1 ATOM 4001 O OE1 . GLU A 1 497 ? 142.083 10.902 60.630 1.00 61.02 ? 497 GLU A OE1 1 ATOM 4002 O OE2 . GLU A 1 497 ? 141.576 8.970 59.609 1.00 64.31 ? 497 GLU A OE2 1 ATOM 4003 N N . GLN A 1 498 ? 136.433 10.498 57.849 1.00 41.74 ? 498 GLN A N 1 ATOM 4004 C CA . GLN A 1 498 ? 135.318 11.112 57.146 1.00 39.32 ? 498 GLN A CA 1 ATOM 4005 C C . GLN A 1 498 ? 135.258 12.640 57.340 1.00 38.63 ? 498 GLN A C 1 ATOM 4006 O O . GLN A 1 498 ? 134.196 13.223 57.682 1.00 37.57 ? 498 GLN A O 1 ATOM 4007 C CB . GLN A 1 498 ? 134.028 10.461 57.626 1.00 40.39 ? 498 GLN A CB 1 ATOM 4008 C CG . GLN A 1 498 ? 133.975 8.985 57.407 1.00 40.42 ? 498 GLN A CG 1 ATOM 4009 C CD . GLN A 1 498 ? 132.867 8.335 58.194 1.00 44.48 ? 498 GLN A CD 1 ATOM 4010 O OE1 . GLN A 1 498 ? 131.739 8.839 58.263 1.00 39.33 ? 498 GLN A OE1 1 ATOM 4011 N NE2 . GLN A 1 498 ? 133.183 7.191 58.786 1.00 48.38 ? 498 GLN A NE2 1 ATOM 4012 N N . LYS A 1 499 ? 136.420 13.261 57.154 1.00 37.35 ? 499 LYS A N 1 ATOM 4013 C CA . LYS A 1 499 ? 136.573 14.705 57.208 1.00 37.41 ? 499 LYS A CA 1 ATOM 4014 C C . LYS A 1 499 ? 135.937 15.306 55.971 1.00 36.33 ? 499 LYS A C 1 ATOM 4015 O O . LYS A 1 499 ? 136.073 14.768 54.866 1.00 36.79 ? 499 LYS A O 1 ATOM 4016 C CB . LYS A 1 499 ? 138.051 15.137 57.330 1.00 35.67 ? 499 LYS A CB 1 ATOM 4017 C CG . LYS A 1 499 ? 138.720 14.658 58.610 1.00 37.49 ? 499 LYS A CG 1 ATOM 4018 C CD . LYS A 1 499 ? 140.122 15.260 58.813 1.00 37.67 ? 499 LYS A CD 1 ATOM 4019 C CE . LYS A 1 499 ? 140.967 14.411 59.817 1.00 39.73 ? 499 LYS A CE 1 ATOM 4020 N NZ . LYS A 1 499 ? 142.322 15.013 59.870 1.00 40.33 ? 499 LYS A NZ 1 ATOM 4021 N N . TYR A 1 500 ? 135.254 16.423 56.192 1.00 35.68 ? 500 TYR A N 1 ATOM 4022 C CA . TYR A 1 500 ? 134.648 17.196 55.124 1.00 35.94 ? 500 TYR A CA 1 ATOM 4023 C C . TYR A 1 500 ? 134.828 18.699 55.398 1.00 36.30 ? 500 TYR A C 1 ATOM 4024 O O . TYR A 1 500 ? 134.953 19.109 56.557 1.00 36.45 ? 500 TYR A O 1 ATOM 4025 C CB . TYR A 1 500 ? 133.174 16.827 54.967 1.00 33.55 ? 500 TYR A CB 1 ATOM 4026 C CG . TYR A 1 500 ? 132.264 17.228 56.112 1.00 32.79 ? 500 TYR A CG 1 ATOM 4027 C CD1 . TYR A 1 500 ? 132.097 16.389 57.214 1.00 29.93 ? 500 TYR A CD1 1 ATOM 4028 C CD2 . TYR A 1 500 ? 131.502 18.403 56.057 1.00 30.04 ? 500 TYR A CD2 1 ATOM 4029 C CE1 . TYR A 1 500 ? 131.255 16.739 58.298 1.00 30.92 ? 500 TYR A CE1 1 ATOM 4030 C CE2 . TYR A 1 500 ? 130.620 18.747 57.124 1.00 33.40 ? 500 TYR A CE2 1 ATOM 4031 C CZ . TYR A 1 500 ? 130.535 17.912 58.253 1.00 30.93 ? 500 TYR A CZ 1 ATOM 4032 O OH . TYR A 1 500 ? 129.702 18.224 59.316 1.00 31.37 ? 500 TYR A OH 1 ATOM 4033 N N . LEU A 1 501 ? 134.784 19.499 54.337 1.00 37.09 ? 501 LEU A N 1 ATOM 4034 C CA . LEU A 1 501 ? 134.934 20.971 54.419 1.00 38.25 ? 501 LEU A CA 1 ATOM 4035 C C . LEU A 1 501 ? 133.566 21.701 54.298 1.00 38.06 ? 501 LEU A C 1 ATOM 4036 O O . LEU A 1 501 ? 132.765 21.333 53.464 1.00 36.54 ? 501 LEU A O 1 ATOM 4037 C CB . LEU A 1 501 ? 135.880 21.456 53.310 1.00 37.78 ? 501 LEU A CB 1 ATOM 4038 C CG . LEU A 1 501 ? 136.209 22.960 53.152 1.00 40.54 ? 501 LEU A CG 1 ATOM 4039 C CD1 . LEU A 1 501 ? 137.035 23.351 54.353 1.00 44.07 ? 501 LEU A CD1 1 ATOM 4040 C CD2 . LEU A 1 501 ? 137.011 23.279 51.920 1.00 39.57 ? 501 LEU A CD2 1 ATOM 4041 N N . THR A 1 502 ? 133.313 22.702 55.152 1.00 39.67 ? 502 THR A N 1 ATOM 4042 C CA . THR A 1 502 ? 132.092 23.502 55.064 1.00 40.60 ? 502 THR A CA 1 ATOM 4043 C C . THR A 1 502 ? 132.355 24.748 54.248 1.00 41.10 ? 502 THR A C 1 ATOM 4044 O O . THR A 1 502 ? 133.445 25.325 54.328 1.00 40.43 ? 502 THR A O 1 ATOM 4045 C CB . THR A 1 502 ? 131.465 23.864 56.436 1.00 41.83 ? 502 THR A CB 1 ATOM 4046 O OG1 . THR A 1 502 ? 132.356 24.695 57.206 1.00 41.93 ? 502 THR A OG1 1 ATOM 4047 C CG2 . THR A 1 502 ? 131.241 22.594 57.266 1.00 39.12 ? 502 THR A CG2 1 ATOM 4048 N N . LEU A 1 503 ? 131.369 25.125 53.432 1.00 40.58 ? 503 LEU A N 1 ATOM 4049 C CA . LEU A 1 503 ? 131.522 26.217 52.526 1.00 41.49 ? 503 LEU A CA 1 ATOM 4050 C C . LEU A 1 503 ? 130.484 27.221 52.959 1.00 43.91 ? 503 LEU A C 1 ATOM 4051 O O . LEU A 1 503 ? 129.282 26.943 52.973 1.00 44.15 ? 503 LEU A O 1 ATOM 4052 C CB . LEU A 1 503 ? 131.335 25.791 51.065 1.00 40.87 ? 503 LEU A CB 1 ATOM 4053 C CG . LEU A 1 503 ? 132.306 24.806 50.414 1.00 40.49 ? 503 LEU A CG 1 ATOM 4054 C CD1 . LEU A 1 503 ? 131.780 24.368 49.032 1.00 35.95 ? 503 LEU A CD1 1 ATOM 4055 C CD2 . LEU A 1 503 ? 133.734 25.363 50.346 1.00 38.16 ? 503 LEU A CD2 1 ATOM 4056 N N . ASN A 1 504 ? 130.965 28.384 53.374 1.00 46.42 ? 504 ASN A N 1 ATOM 4057 C CA . ASN A 1 504 ? 130.094 29.462 53.838 1.00 48.72 ? 504 ASN A CA 1 ATOM 4058 C C . ASN A 1 504 ? 130.860 30.791 53.751 1.00 49.72 ? 504 ASN A C 1 ATOM 4059 O O . ASN A 1 504 ? 132.083 30.793 53.514 1.00 48.94 ? 504 ASN A O 1 ATOM 4060 C CB . ASN A 1 504 ? 129.516 29.168 55.245 1.00 47.60 ? 504 ASN A CB 1 ATOM 4061 C CG . ASN A 1 504 ? 130.588 29.088 56.311 1.00 51.27 ? 504 ASN A CG 1 ATOM 4062 O OD1 . ASN A 1 504 ? 131.123 30.112 56.709 1.00 52.67 ? 504 ASN A OD1 1 ATOM 4063 N ND2 . ASN A 1 504 ? 130.915 27.864 56.787 1.00 52.71 ? 504 ASN A ND2 1 ATOM 4064 N N . THR A 1 505 ? 130.140 31.907 53.931 1.00 52.32 ? 505 THR A N 1 ATOM 4065 C CA . THR A 1 505 ? 130.773 33.230 53.849 1.00 54.63 ? 505 THR A CA 1 ATOM 4066 C C . THR A 1 505 ? 131.648 33.547 55.060 1.00 57.68 ? 505 THR A C 1 ATOM 4067 O O . THR A 1 505 ? 132.712 34.158 54.904 1.00 59.50 ? 505 THR A O 1 ATOM 4068 C CB . THR A 1 505 ? 129.776 34.368 53.606 1.00 54.06 ? 505 THR A CB 1 ATOM 4069 O OG1 . THR A 1 505 ? 128.776 34.374 54.638 1.00 53.50 ? 505 THR A OG1 1 ATOM 4070 C CG2 . THR A 1 505 ? 129.039 34.203 52.253 1.00 49.58 ? 505 THR A CG2 1 ATOM 4071 N N . GLU A 1 506 ? 131.217 33.126 56.249 1.00 59.80 ? 506 GLU A N 1 ATOM 4072 C CA . GLU A 1 506 ? 131.974 33.392 57.480 1.00 61.63 ? 506 GLU A CA 1 ATOM 4073 C C . GLU A 1 506 ? 133.357 32.678 57.581 1.00 62.13 ? 506 GLU A C 1 ATOM 4074 O O . GLU A 1 506 ? 134.414 33.326 57.520 1.00 63.21 ? 506 GLU A O 1 ATOM 4075 C CB . GLU A 1 506 ? 131.091 33.127 58.710 1.00 62.42 ? 506 GLU A CB 1 ATOM 4076 C CG . GLU A 1 506 ? 130.002 32.079 58.489 1.00 65.48 ? 506 GLU A CG 1 ATOM 4077 C CD . GLU A 1 506 ? 128.903 32.111 59.547 1.00 69.80 ? 506 GLU A CD 1 ATOM 4078 O OE1 . GLU A 1 506 ? 128.816 31.126 60.345 1.00 73.15 ? 506 GLU A OE1 1 ATOM 4079 O OE2 . GLU A 1 506 ? 128.125 33.103 59.585 1.00 69.17 ? 506 GLU A OE2 1 ATOM 4080 N N . SER A 1 507 ? 133.341 31.347 57.683 1.00 61.85 ? 507 SER A N 1 ATOM 4081 C CA . SER A 1 507 ? 134.484 30.543 58.106 1.00 60.77 ? 507 SER A CA 1 ATOM 4082 C C . SER A 1 507 ? 134.355 29.189 57.495 1.00 59.50 ? 507 SER A C 1 ATOM 4083 O O . SER A 1 507 ? 133.305 28.567 57.627 1.00 59.70 ? 507 SER A O 1 ATOM 4084 C CB . SER A 1 507 ? 134.342 30.306 59.605 1.00 62.14 ? 507 SER A CB 1 ATOM 4085 O OG . SER A 1 507 ? 133.062 29.730 59.882 1.00 63.58 ? 507 SER A OG 1 ATOM 4086 N N . THR A 1 508 ? 135.380 28.698 56.828 1.00 57.50 ? 508 THR A N 1 ATOM 4087 C CA . THR A 1 508 ? 135.314 27.309 56.457 1.00 56.47 ? 508 THR A CA 1 ATOM 4088 C C . THR A 1 508 ? 135.789 26.468 57.618 1.00 55.06 ? 508 THR A C 1 ATOM 4089 O O . THR A 1 508 ? 136.808 26.782 58.236 1.00 55.63 ? 508 THR A O 1 ATOM 4090 C CB . THR A 1 508 ? 136.131 26.964 55.210 1.00 56.30 ? 508 THR A CB 1 ATOM 4091 O OG1 . THR A 1 508 ? 137.511 26.870 55.559 1.00 58.64 ? 508 THR A OG1 1 ATOM 4092 C CG2 . THR A 1 508 ? 136.064 28.062 54.222 1.00 57.86 ? 508 THR A CG2 1 ATOM 4093 N N . ARG A 1 509 ? 135.060 25.387 57.887 1.00 52.74 ? 509 ARG A N 1 ATOM 4094 C CA . ARG A 1 509 ? 135.436 24.488 58.927 1.00 51.01 ? 509 ARG A CA 1 ATOM 4095 C C . ARG A 1 509 ? 135.762 23.108 58.398 1.00 49.22 ? 509 ARG A C 1 ATOM 4096 O O . ARG A 1 509 ? 135.179 22.652 57.393 1.00 48.81 ? 509 ARG A O 1 ATOM 4097 C CB . ARG A 1 509 ? 134.355 24.472 59.997 1.00 51.84 ? 509 ARG A CB 1 ATOM 4098 C CG . ARG A 1 509 ? 134.559 25.607 60.959 1.00 54.31 ? 509 ARG A CG 1 ATOM 4099 C CD . ARG A 1 509 ? 133.340 26.072 61.748 1.00 62.95 ? 509 ARG A CD 1 ATOM 4100 N NE . ARG A 1 509 ? 133.539 27.466 62.192 0.80 68.00 ? 509 ARG A NE 1 ATOM 4101 C CZ . ARG A 1 509 ? 134.575 27.905 62.936 1.00 70.73 ? 509 ARG A CZ 1 ATOM 4102 N NH1 . ARG A 1 509 ? 135.535 27.065 63.356 1.00 68.76 ? 509 ARG A NH1 1 ATOM 4103 N NH2 . ARG A 1 509 ? 134.659 29.204 63.239 1.00 71.49 ? 509 ARG A NH2 1 ATOM 4104 N N . ILE A 1 510 ? 136.746 22.478 59.044 1.00 46.06 ? 510 ILE A N 1 ATOM 4105 C CA . ILE A 1 510 ? 136.915 21.052 58.932 1.00 43.42 ? 510 ILE A CA 1 ATOM 4106 C C . ILE A 1 510 ? 136.056 20.360 59.985 1.00 41.36 ? 510 ILE A C 1 ATOM 4107 O O . ILE A 1 510 ? 136.221 20.586 61.180 1.00 40.93 ? 510 ILE A O 1 ATOM 4108 C CB . ILE A 1 510 ? 138.405 20.603 59.014 1.00 43.44 ? 510 ILE A CB 1 ATOM 4109 C CG1 . ILE A 1 510 ? 139.253 21.290 57.928 1.00 45.85 ? 510 ILE A CG1 1 ATOM 4110 C CG2 . ILE A 1 510 ? 138.528 19.115 58.752 1.00 42.46 ? 510 ILE A CG2 1 ATOM 4111 C CD1 . ILE A 1 510 ? 138.595 21.357 56.553 1.00 47.62 ? 510 ILE A CD1 1 ATOM 4112 N N A MET A 1 511 ? 135.163 19.495 59.523 0.50 40.37 ? 511 MET A N 1 ATOM 4113 N N B MET A 1 511 ? 135.129 19.529 59.515 0.50 40.12 ? 511 MET A N 1 ATOM 4114 C CA A MET A 1 511 ? 134.315 18.702 60.411 0.50 39.09 ? 511 MET A CA 1 ATOM 4115 C CA B MET A 1 511 ? 134.226 18.744 60.369 0.50 38.67 ? 511 MET A CA 1 ATOM 4116 C C A MET A 1 511 ? 134.346 17.231 60.037 0.50 38.40 ? 511 MET A C 1 ATOM 4117 C C B MET A 1 511 ? 134.338 17.250 60.042 0.50 38.12 ? 511 MET A C 1 ATOM 4118 O O A MET A 1 511 ? 134.944 16.843 59.004 0.50 38.07 ? 511 MET A O 1 ATOM 4119 O O B MET A 1 511 ? 134.971 16.868 59.028 0.50 37.85 ? 511 MET A O 1 ATOM 4120 C CB A MET A 1 511 ? 132.901 19.253 60.381 0.50 39.25 ? 511 MET A CB 1 ATOM 4121 C CB B MET A 1 511 ? 132.789 19.219 60.167 0.50 38.44 ? 511 MET A CB 1 ATOM 4122 C CG A MET A 1 511 ? 132.850 20.659 60.951 0.50 38.74 ? 511 MET A CG 1 ATOM 4123 C CG B MET A 1 511 ? 132.560 20.715 60.439 0.50 37.40 ? 511 MET A CG 1 ATOM 4124 S SD A MET A 1 511 ? 131.222 21.371 61.037 0.50 39.30 ? 511 MET A SD 1 ATOM 4125 S SD B MET A 1 511 ? 132.842 21.185 62.163 0.50 34.27 ? 511 MET A SD 1 ATOM 4126 C CE A MET A 1 511 ? 130.528 20.453 62.407 0.50 35.08 ? 511 MET A CE 1 ATOM 4127 C CE B MET A 1 511 ? 131.305 20.625 62.916 0.50 35.99 ? 511 MET A CE 1 ATOM 4128 N N . THR A 1 512 ? 133.731 16.406 60.878 1.00 37.75 ? 512 THR A N 1 ATOM 4129 C CA . THR A 1 512 ? 133.732 14.948 60.671 1.00 36.55 ? 512 THR A CA 1 ATOM 4130 C C . THR A 1 512 ? 132.352 14.320 60.755 1.00 36.33 ? 512 THR A C 1 ATOM 4131 O O . THR A 1 512 ? 131.465 14.735 61.529 1.00 34.36 ? 512 THR A O 1 ATOM 4132 C CB . THR A 1 512 ? 134.660 14.225 61.704 1.00 37.34 ? 512 THR A CB 1 ATOM 4133 O OG1 . THR A 1 512 ? 134.308 14.666 63.017 1.00 41.05 ? 512 THR A OG1 1 ATOM 4134 C CG2 . THR A 1 512 ? 136.154 14.653 61.565 1.00 34.36 ? 512 THR A CG2 1 ATOM 4135 N N . LYS A 1 513 ? 132.168 13.300 59.932 1.00 36.67 ? 513 LYS A N 1 ATOM 4136 C CA . LYS A 1 513 ? 131.037 12.396 60.086 1.00 36.86 ? 513 LYS A CA 1 ATOM 4137 C C . LYS A 1 513 ? 129.715 13.115 59.949 1.00 36.13 ? 513 LYS A C 1 ATOM 4138 O O . LYS A 1 513 ? 128.890 13.125 60.872 1.00 36.56 ? 513 LYS A O 1 ATOM 4139 C CB . LYS A 1 513 ? 131.182 11.588 61.406 1.00 37.36 ? 513 LYS A CB 1 ATOM 4140 C CG . LYS A 1 513 ? 132.295 10.494 61.308 1.00 38.87 ? 513 LYS A CG 1 ATOM 4141 C CD . LYS A 1 513 ? 132.719 9.974 62.689 1.00 40.10 ? 513 LYS A CD 1 ATOM 4142 C CE . LYS A 1 513 ? 133.810 8.919 62.597 1.00 43.92 ? 513 LYS A CE 1 ATOM 4143 N NZ . LYS A 1 513 ? 134.002 8.171 63.919 1.00 48.02 ? 513 LYS A NZ 1 ATOM 4144 N N . LEU A 1 514 ? 129.531 13.754 58.792 1.00 36.61 ? 514 LEU A N 1 ATOM 4145 C CA . LEU A 1 514 ? 128.286 14.494 58.483 1.00 36.31 ? 514 LEU A CA 1 ATOM 4146 C C . LEU A 1 514 ? 127.068 13.571 58.701 1.00 36.85 ? 514 LEU A C 1 ATOM 4147 O O . LEU A 1 514 ? 127.053 12.432 58.185 1.00 37.15 ? 514 LEU A O 1 ATOM 4148 C CB . LEU A 1 514 ? 128.330 14.961 57.043 1.00 34.74 ? 514 LEU A CB 1 ATOM 4149 C CG . LEU A 1 514 ? 127.197 15.807 56.457 1.00 36.55 ? 514 LEU A CG 1 ATOM 4150 C CD1 . LEU A 1 514 ? 126.909 17.095 57.281 1.00 34.99 ? 514 LEU A CD1 1 ATOM 4151 C CD2 . LEU A 1 514 ? 127.515 16.143 54.968 1.00 36.20 ? 514 LEU A CD2 1 ATOM 4152 N N . ARG A 1 515 ? 126.076 14.023 59.455 1.00 37.30 ? 515 ARG A N 1 ATOM 4153 C CA . ARG A 1 515 ? 124.799 13.285 59.532 1.00 39.37 ? 515 ARG A CA 1 ATOM 4154 C C . ARG A 1 515 ? 124.978 11.828 59.947 1.00 40.08 ? 515 ARG A C 1 ATOM 4155 O O . ARG A 1 515 ? 124.284 10.962 59.429 1.00 40.27 ? 515 ARG A O 1 ATOM 4156 C CB . ARG A 1 515 ? 124.066 13.294 58.159 1.00 38.81 ? 515 ARG A CB 1 ATOM 4157 C CG . ARG A 1 515 ? 123.617 14.629 57.654 1.00 39.73 ? 515 ARG A CG 1 ATOM 4158 C CD . ARG A 1 515 ? 122.235 15.043 58.157 1.00 42.38 ? 515 ARG A CD 1 ATOM 4159 N NE . ARG A 1 515 ? 121.649 16.131 57.398 1.00 40.41 ? 515 ARG A NE 1 ATOM 4160 C CZ . ARG A 1 515 ? 122.220 17.326 57.285 1.00 47.88 ? 515 ARG A CZ 1 ATOM 4161 N NH1 . ARG A 1 515 ? 121.655 18.324 56.560 1.00 44.68 ? 515 ARG A NH1 1 ATOM 4162 N NH2 . ARG A 1 515 ? 123.366 17.542 57.938 1.00 47.61 ? 515 ARG A NH2 1 ATOM 4163 N N . ALA A 1 516 ? 125.900 11.547 60.872 1.00 41.22 ? 516 ALA A N 1 ATOM 4164 C CA . ALA A 1 516 ? 126.283 10.171 61.136 1.00 42.02 ? 516 ALA A CA 1 ATOM 4165 C C . ALA A 1 516 ? 125.087 9.306 61.641 1.00 42.73 ? 516 ALA A C 1 ATOM 4166 O O . ALA A 1 516 ? 124.916 8.163 61.198 1.00 41.38 ? 516 ALA A O 1 ATOM 4167 C CB . ALA A 1 516 ? 127.463 10.131 62.107 1.00 42.26 ? 516 ALA A CB 1 ATOM 4168 N N . GLN A 1 517 ? 124.253 9.840 62.543 1.00 43.96 ? 517 GLN A N 1 ATOM 4169 C CA . GLN A 1 517 ? 123.094 9.059 63.067 1.00 45.48 ? 517 GLN A CA 1 ATOM 4170 C C . GLN A 1 517 ? 122.017 8.848 62.003 1.00 44.56 ? 517 GLN A C 1 ATOM 4171 O O . GLN A 1 517 ? 121.480 7.761 61.850 1.00 43.40 ? 517 GLN A O 1 ATOM 4172 C CB . GLN A 1 517 ? 122.450 9.765 64.244 1.00 47.12 ? 517 GLN A CB 1 ATOM 4173 C CG . GLN A 1 517 ? 123.038 9.467 65.612 1.00 52.83 ? 517 GLN A CG 1 ATOM 4174 C CD . GLN A 1 517 ? 122.162 10.082 66.700 1.00 60.17 ? 517 GLN A CD 1 ATOM 4175 O OE1 . GLN A 1 517 ? 121.127 9.508 67.073 1.00 60.50 ? 517 GLN A OE1 1 ATOM 4176 N NE2 . GLN A 1 517 ? 122.542 11.277 67.166 1.00 60.66 ? 517 GLN A NE2 1 ATOM 4177 N N . GLN A 1 518 ? 121.765 9.899 61.230 1.00 44.44 ? 518 GLN A N 1 ATOM 4178 C CA . GLN A 1 518 ? 120.781 9.867 60.162 1.00 43.93 ? 518 GLN A CA 1 ATOM 4179 C C . GLN A 1 518 ? 121.115 8.866 59.106 1.00 43.87 ? 518 GLN A C 1 ATOM 4180 O O . GLN A 1 518 ? 120.272 8.098 58.683 1.00 44.06 ? 518 GLN A O 1 ATOM 4181 C CB . GLN A 1 518 ? 120.646 11.249 59.548 1.00 43.72 ? 518 GLN A CB 1 ATOM 4182 C CG . GLN A 1 518 ? 120.101 12.221 60.564 1.00 44.24 ? 518 GLN A CG 1 ATOM 4183 C CD . GLN A 1 518 ? 121.190 12.979 61.333 1.00 46.45 ? 518 GLN A CD 1 ATOM 4184 O OE1 . GLN A 1 518 ? 120.986 14.122 61.655 1.00 51.02 ? 518 GLN A OE1 1 ATOM 4185 N NE2 . GLN A 1 518 ? 122.333 12.352 61.596 1.00 44.74 ? 518 GLN A NE2 1 ATOM 4186 N N . CYS A 1 519 ? 122.371 8.839 58.694 1.00 44.88 ? 519 CYS A N 1 ATOM 4187 C CA . CYS A 1 519 ? 122.772 7.978 57.608 1.00 45.48 ? 519 CYS A CA 1 ATOM 4188 C C . CYS A 1 519 ? 122.869 6.505 58.033 1.00 45.58 ? 519 CYS A C 1 ATOM 4189 O O . CYS A 1 519 ? 122.545 5.611 57.222 1.00 45.35 ? 519 CYS A O 1 ATOM 4190 C CB . CYS A 1 519 ? 124.034 8.536 56.944 1.00 46.60 ? 519 CYS A CB 1 ATOM 4191 S SG . CYS A 1 519 ? 123.673 10.100 56.056 1.00 51.82 ? 519 CYS A SG 1 ATOM 4192 N N . ARG A 1 520 ? 123.232 6.245 59.297 1.00 44.16 ? 520 ARG A N 1 ATOM 4193 C CA . ARG A 1 520 ? 123.160 4.884 59.813 1.00 44.84 ? 520 ARG A CA 1 ATOM 4194 C C . ARG A 1 520 ? 121.748 4.354 59.582 1.00 43.42 ? 520 ARG A C 1 ATOM 4195 O O . ARG A 1 520 ? 121.587 3.272 59.076 1.00 41.89 ? 520 ARG A O 1 ATOM 4196 C CB . ARG A 1 520 ? 123.547 4.765 61.308 1.00 45.68 ? 520 ARG A CB 1 ATOM 4197 C CG . ARG A 1 520 ? 125.014 4.327 61.569 1.00 51.82 ? 520 ARG A CG 1 ATOM 4198 C CD . ARG A 1 520 ? 125.483 4.359 63.083 1.00 54.18 ? 520 ARG A CD 1 ATOM 4199 N NE . ARG A 1 520 ? 126.269 5.558 63.448 1.00 57.19 ? 520 ARG A NE 1 ATOM 4200 C CZ . ARG A 1 520 ? 125.889 6.492 64.327 1.00 55.59 ? 520 ARG A CZ 1 ATOM 4201 N NH1 . ARG A 1 520 ? 126.686 7.523 64.588 1.00 56.67 ? 520 ARG A NH1 1 ATOM 4202 N NH2 . ARG A 1 520 ? 124.723 6.394 64.968 1.00 60.23 ? 520 ARG A NH2 1 ATOM 4203 N N . PHE A 1 521 ? 120.740 5.151 59.937 1.00 42.43 ? 521 PHE A N 1 ATOM 4204 C CA . PHE A 1 521 ? 119.349 4.805 59.657 1.00 42.37 ? 521 PHE A CA 1 ATOM 4205 C C . PHE A 1 521 ? 119.002 4.504 58.164 1.00 42.64 ? 521 PHE A C 1 ATOM 4206 O O . PHE A 1 521 ? 118.433 3.471 57.847 1.00 43.27 ? 521 PHE A O 1 ATOM 4207 C CB . PHE A 1 521 ? 118.421 5.890 60.238 1.00 41.69 ? 521 PHE A CB 1 ATOM 4208 C CG . PHE A 1 521 ? 116.974 5.668 59.907 1.00 42.76 ? 521 PHE A CG 1 ATOM 4209 C CD1 . PHE A 1 521 ? 116.223 4.710 60.611 1.00 40.49 ? 521 PHE A CD1 1 ATOM 4210 C CD2 . PHE A 1 521 ? 116.369 6.381 58.873 1.00 40.10 ? 521 PHE A CD2 1 ATOM 4211 C CE1 . PHE A 1 521 ? 114.901 4.478 60.267 1.00 41.10 ? 521 PHE A CE1 1 ATOM 4212 C CE2 . PHE A 1 521 ? 115.035 6.156 58.528 1.00 42.04 ? 521 PHE A CE2 1 ATOM 4213 C CZ . PHE A 1 521 ? 114.291 5.206 59.239 1.00 40.55 ? 521 PHE A CZ 1 ATOM 4214 N N . TRP A 1 522 ? 119.323 5.422 57.259 1.00 43.15 ? 522 TRP A N 1 ATOM 4215 C CA . TRP A 1 522 ? 118.960 5.284 55.854 1.00 43.41 ? 522 TRP A CA 1 ATOM 4216 C C . TRP A 1 522 ? 119.765 4.199 55.199 1.00 45.34 ? 522 TRP A C 1 ATOM 4217 O O . TRP A 1 522 ? 119.281 3.422 54.394 1.00 46.37 ? 522 TRP A O 1 ATOM 4218 C CB . TRP A 1 522 ? 119.143 6.640 55.129 1.00 41.87 ? 522 TRP A CB 1 ATOM 4219 C CG . TRP A 1 522 ? 118.133 7.643 55.566 1.00 40.37 ? 522 TRP A CG 1 ATOM 4220 C CD1 . TRP A 1 522 ? 118.356 8.794 56.301 1.00 41.44 ? 522 TRP A CD1 1 ATOM 4221 C CD2 . TRP A 1 522 ? 116.717 7.572 55.368 1.00 37.50 ? 522 TRP A CD2 1 ATOM 4222 N NE1 . TRP A 1 522 ? 117.165 9.430 56.574 1.00 39.64 ? 522 TRP A NE1 1 ATOM 4223 C CE2 . TRP A 1 522 ? 116.140 8.705 56.005 1.00 39.52 ? 522 TRP A CE2 1 ATOM 4224 C CE3 . TRP A 1 522 ? 115.867 6.659 54.726 1.00 37.91 ? 522 TRP A CE3 1 ATOM 4225 C CZ2 . TRP A 1 522 ? 114.751 8.951 56.000 1.00 36.74 ? 522 TRP A CZ2 1 ATOM 4226 C CZ3 . TRP A 1 522 ? 114.481 6.886 54.755 1.00 38.42 ? 522 TRP A CZ3 1 ATOM 4227 C CH2 . TRP A 1 522 ? 113.941 8.035 55.382 1.00 36.39 ? 522 TRP A CH2 1 ATOM 4228 N N . THR A 1 523 ? 121.025 4.130 55.586 1.00 48.34 ? 523 THR A N 1 ATOM 4229 C CA . THR A 1 523 ? 121.993 3.286 54.930 1.00 50.24 ? 523 THR A CA 1 ATOM 4230 C C . THR A 1 523 ? 121.963 1.843 55.405 1.00 51.96 ? 523 THR A C 1 ATOM 4231 O O . THR A 1 523 ? 122.078 0.924 54.584 1.00 52.51 ? 523 THR A O 1 ATOM 4232 C CB . THR A 1 523 ? 123.359 3.961 55.089 1.00 49.79 ? 523 THR A CB 1 ATOM 4233 O OG1 . THR A 1 523 ? 123.282 5.250 54.431 1.00 51.67 ? 523 THR A OG1 1 ATOM 4234 C CG2 . THR A 1 523 ? 124.460 3.217 54.359 1.00 50.28 ? 523 THR A CG2 1 ATOM 4235 N N . SER A 1 524 ? 121.757 1.631 56.706 1.00 53.06 ? 524 SER A N 1 ATOM 4236 C CA . SER A 1 524 ? 121.874 0.283 57.262 1.00 54.54 ? 524 SER A CA 1 ATOM 4237 C C . SER A 1 524 ? 120.570 -0.320 57.665 1.00 55.25 ? 524 SER A C 1 ATOM 4238 O O . SER A 1 524 ? 120.437 -1.529 57.622 1.00 57.48 ? 524 SER A O 1 ATOM 4239 C CB . SER A 1 524 ? 122.809 0.252 58.490 1.00 55.31 ? 524 SER A CB 1 ATOM 4240 O OG . SER A 1 524 ? 124.138 0.637 58.151 1.00 54.40 ? 524 SER A OG 1 ATOM 4241 N N . PHE A 1 525 ? 119.613 0.481 58.100 1.00 54.97 ? 525 PHE A N 1 ATOM 4242 C CA . PHE A 1 525 ? 118.337 -0.089 58.468 1.00 55.01 ? 525 PHE A CA 1 ATOM 4243 C C . PHE A 1 525 ? 117.273 0.005 57.351 1.00 55.79 ? 525 PHE A C 1 ATOM 4244 O O . PHE A 1 525 ? 116.673 -1.023 56.952 1.00 55.61 ? 525 PHE A O 1 ATOM 4245 C CB . PHE A 1 525 ? 117.788 0.546 59.736 1.00 55.01 ? 525 PHE A CB 1 ATOM 4246 C CG . PHE A 1 525 ? 116.353 0.205 59.983 1.00 56.75 ? 525 PHE A CG 1 ATOM 4247 C CD1 . PHE A 1 525 ? 115.474 1.149 60.441 1.00 56.42 ? 525 PHE A CD1 1 ATOM 4248 C CD2 . PHE A 1 525 ? 115.877 -1.111 59.747 1.00 58.71 ? 525 PHE A CD2 1 ATOM 4249 C CE1 . PHE A 1 525 ? 114.124 0.824 60.649 1.00 55.80 ? 525 PHE A CE1 1 ATOM 4250 C CE2 . PHE A 1 525 ? 114.562 -1.448 59.948 1.00 57.64 ? 525 PHE A CE2 1 ATOM 4251 C CZ . PHE A 1 525 ? 113.677 -0.461 60.398 1.00 57.81 ? 525 PHE A CZ 1 ATOM 4252 N N . PHE A 1 526 ? 117.020 1.225 56.857 1.00 54.72 ? 526 PHE A N 1 ATOM 4253 C CA . PHE A 1 526 ? 115.935 1.422 55.897 1.00 53.59 ? 526 PHE A CA 1 ATOM 4254 C C . PHE A 1 526 ? 115.911 0.498 54.625 1.00 53.99 ? 526 PHE A C 1 ATOM 4255 O O . PHE A 1 526 ? 114.812 0.137 54.169 1.00 53.09 ? 526 PHE A O 1 ATOM 4256 C CB . PHE A 1 526 ? 115.796 2.910 55.515 1.00 52.46 ? 526 PHE A CB 1 ATOM 4257 C CG . PHE A 1 526 ? 114.434 3.263 54.963 1.00 48.91 ? 526 PHE A CG 1 ATOM 4258 C CD1 . PHE A 1 526 ? 113.352 3.431 55.805 1.00 46.75 ? 526 PHE A CD1 1 ATOM 4259 C CD2 . PHE A 1 526 ? 114.232 3.387 53.606 1.00 43.93 ? 526 PHE A CD2 1 ATOM 4260 C CE1 . PHE A 1 526 ? 112.106 3.748 55.299 1.00 44.72 ? 526 PHE A CE1 1 ATOM 4261 C CE2 . PHE A 1 526 ? 112.986 3.712 53.099 1.00 43.87 ? 526 PHE A CE2 1 ATOM 4262 C CZ . PHE A 1 526 ? 111.934 3.905 53.945 1.00 44.69 ? 526 PHE A CZ 1 ATOM 4263 N N . PRO A 1 527 ? 117.062 0.174 54.016 1.00 54.55 ? 527 PRO A N 1 ATOM 4264 C CA . PRO A 1 527 ? 117.075 -0.738 52.862 1.00 55.98 ? 527 PRO A CA 1 ATOM 4265 C C . PRO A 1 527 ? 116.317 -2.063 53.108 1.00 57.89 ? 527 PRO A C 1 ATOM 4266 O O . PRO A 1 527 ? 116.043 -2.826 52.153 1.00 57.25 ? 527 PRO A O 1 ATOM 4267 C CB . PRO A 1 527 ? 118.574 -1.000 52.620 1.00 55.53 ? 527 PRO A CB 1 ATOM 4268 C CG . PRO A 1 527 ? 119.250 0.188 53.139 1.00 55.56 ? 527 PRO A CG 1 ATOM 4269 C CD . PRO A 1 527 ? 118.411 0.697 54.296 1.00 54.72 ? 527 PRO A CD 1 ATOM 4270 N N . LYS A 1 528 ? 115.968 -2.302 54.377 1.00 59.46 ? 528 LYS A N 1 ATOM 4271 C CA . LYS A 1 528 ? 115.343 -3.545 54.801 1.00 61.26 ? 528 LYS A CA 1 ATOM 4272 C C . LYS A 1 528 ? 113.826 -3.541 54.698 1.00 62.37 ? 528 LYS A C 1 ATOM 4273 O O . LYS A 1 528 ? 113.227 -4.559 54.331 1.00 62.83 ? 528 LYS A O 1 ATOM 4274 C CB . LYS A 1 528 ? 115.795 -3.902 56.217 1.00 60.66 ? 528 LYS A CB 1 ATOM 4275 C CG . LYS A 1 528 ? 117.157 -4.536 56.231 1.00 61.17 ? 528 LYS A CG 1 ATOM 4276 C CD . LYS A 1 528 ? 117.867 -4.393 57.553 1.00 61.48 ? 528 LYS A CD 1 ATOM 4277 C CE . LYS A 1 528 ? 119.275 -4.866 57.379 1.00 61.49 ? 528 LYS A CE 1 ATOM 4278 N NZ . LYS A 1 528 ? 120.145 -4.279 58.399 1.00 62.22 ? 528 LYS A NZ 1 ATOM 4279 N N . VAL A 1 529 ? 113.210 -2.403 55.016 1.00 63.79 ? 529 VAL A N 1 ATOM 4280 C CA . VAL A 1 529 ? 111.738 -2.322 55.170 1.00 64.97 ? 529 VAL A CA 1 ATOM 4281 C C . VAL A 1 529 ? 110.945 -2.738 53.897 1.00 66.07 ? 529 VAL A C 1 ATOM 4282 O O . VAL A 1 529 ? 111.505 -2.863 52.795 1.00 66.58 ? 529 VAL A O 1 ATOM 4283 C CB . VAL A 1 529 ? 111.284 -0.916 55.722 1.00 65.11 ? 529 VAL A CB 1 ATOM 4284 C CG1 . VAL A 1 529 ? 112.065 -0.545 57.014 1.00 63.13 ? 529 VAL A CG1 1 ATOM 4285 C CG2 . VAL A 1 529 ? 111.420 0.184 54.660 1.00 63.79 ? 529 VAL A CG2 1 ATOM 4286 O OXT . VAL A 1 529 ? 109.723 -2.982 53.921 1.00 67.20 ? 529 VAL A OXT 1 HETATM 4287 C C1 . NAG B 2 . ? 102.250 -1.585 36.567 1.00 76.76 ? 530 NAG A C1 1 HETATM 4288 C C2 . NAG B 2 . ? 102.172 -1.390 38.089 1.00 81.48 ? 530 NAG A C2 1 HETATM 4289 C C3 . NAG B 2 . ? 100.763 -1.556 38.674 1.00 81.40 ? 530 NAG A C3 1 HETATM 4290 C C4 . NAG B 2 . ? 99.633 -1.052 37.773 1.00 82.82 ? 530 NAG A C4 1 HETATM 4291 C C5 . NAG B 2 . ? 99.934 -1.199 36.273 1.00 81.17 ? 530 NAG A C5 1 HETATM 4292 C C6 . NAG B 2 . ? 99.022 -0.349 35.407 1.00 80.49 ? 530 NAG A C6 1 HETATM 4293 C C7 . NAG B 2 . ? 104.199 -1.739 39.366 1.00 87.28 ? 530 NAG A C7 1 HETATM 4294 C C8 . NAG B 2 . ? 105.546 -2.072 38.767 1.00 88.23 ? 530 NAG A C8 1 HETATM 4295 N N2 . NAG B 2 . ? 103.122 -2.262 38.767 1.00 84.53 ? 530 NAG A N2 1 HETATM 4296 O O3 . NAG B 2 . ? 100.662 -0.847 39.889 1.00 80.77 ? 530 NAG A O3 1 HETATM 4297 O O4 . NAG B 2 . ? 98.461 -1.773 38.126 1.00 87.19 ? 530 NAG A O4 1 HETATM 4298 O O5 . NAG B 2 . ? 101.244 -0.775 35.984 1.00 79.32 ? 530 NAG A O5 1 HETATM 4299 O O6 . NAG B 2 . ? 98.337 0.585 36.210 1.00 80.51 ? 530 NAG A O6 1 HETATM 4300 O O7 . NAG B 2 . ? 104.122 -0.998 40.359 1.00 87.66 ? 530 NAG A O7 1 HETATM 4301 C C1 . NAG C 2 . ? 97.374 -0.910 38.532 1.00 89.40 ? 531 NAG A C1 1 HETATM 4302 C C2 . NAG C 2 . ? 96.024 -1.621 38.571 1.00 90.02 ? 531 NAG A C2 1 HETATM 4303 C C3 . NAG C 2 . ? 94.940 -0.542 38.748 1.00 92.17 ? 531 NAG A C3 1 HETATM 4304 C C4 . NAG C 2 . ? 95.251 0.579 39.755 1.00 92.97 ? 531 NAG A C4 1 HETATM 4305 C C5 . NAG C 2 . ? 96.737 0.722 40.183 1.00 93.13 ? 531 NAG A C5 1 HETATM 4306 C C6 . NAG C 2 . ? 96.849 0.789 41.709 1.00 93.42 ? 531 NAG A C6 1 HETATM 4307 C C7 . NAG C 2 . ? 96.386 -3.493 36.937 1.00 88.96 ? 531 NAG A C7 1 HETATM 4308 C C8 . NAG C 2 . ? 96.243 -3.801 35.480 1.00 89.79 ? 531 NAG A C8 1 HETATM 4309 N N2 . NAG C 2 . ? 95.758 -2.388 37.357 1.00 89.11 ? 531 NAG A N2 1 HETATM 4310 O O3 . NAG C 2 . ? 93.721 -1.116 39.180 1.00 93.57 ? 531 NAG A O3 1 HETATM 4311 O O4 . NAG C 2 . ? 94.715 1.797 39.251 1.00 92.71 ? 531 NAG A O4 1 HETATM 4312 O O5 . NAG C 2 . ? 97.623 -0.322 39.783 1.00 91.27 ? 531 NAG A O5 1 HETATM 4313 O O6 . NAG C 2 . ? 97.564 -0.343 42.180 1.00 91.78 ? 531 NAG A O6 1 HETATM 4314 O O7 . NAG C 2 . ? 97.066 -4.245 37.635 1.00 88.97 ? 531 NAG A O7 1 HETATM 4315 C C1 . FUL D 3 . ? 98.359 1.861 35.567 1.00 80.65 ? 532 FUL A C1 1 HETATM 4316 C C2 . FUL D 3 . ? 97.631 2.950 36.329 1.00 80.87 ? 532 FUL A C2 1 HETATM 4317 O O2 . FUL D 3 . ? 97.677 2.789 37.722 1.00 79.82 ? 532 FUL A O2 1 HETATM 4318 C C3 . FUL D 3 . ? 98.427 4.172 35.921 1.00 81.92 ? 532 FUL A C3 1 HETATM 4319 O O3 . FUL D 3 . ? 98.045 5.301 36.693 1.00 83.19 ? 532 FUL A O3 1 HETATM 4320 C C4 . FUL D 3 . ? 98.371 4.355 34.380 1.00 82.51 ? 532 FUL A C4 1 HETATM 4321 O O4 . FUL D 3 . ? 97.264 5.163 33.973 1.00 83.88 ? 532 FUL A O4 1 HETATM 4322 C C5 . FUL D 3 . ? 98.542 3.007 33.615 1.00 82.00 ? 532 FUL A C5 1 HETATM 4323 C C6 . FUL D 3 . ? 98.186 3.013 32.130 1.00 81.61 ? 532 FUL A C6 1 HETATM 4324 O O5 . FUL D 3 . ? 97.877 1.924 34.246 1.00 80.54 ? 532 FUL A O5 1 HETATM 4325 C C1 . NAG E 2 . ? 100.254 27.693 54.399 1.00 58.20 ? 533 NAG A C1 1 HETATM 4326 C C2 . NAG E 2 . ? 99.242 27.554 55.544 1.00 62.25 ? 533 NAG A C2 1 HETATM 4327 C C3 . NAG E 2 . ? 98.476 26.234 55.410 1.00 63.21 ? 533 NAG A C3 1 HETATM 4328 C C4 . NAG E 2 . ? 97.869 26.003 54.014 1.00 65.74 ? 533 NAG A C4 1 HETATM 4329 C C5 . NAG E 2 . ? 98.893 26.303 52.906 1.00 62.12 ? 533 NAG A C5 1 HETATM 4330 C C6 . NAG E 2 . ? 98.201 26.370 51.536 1.00 62.41 ? 533 NAG A C6 1 HETATM 4331 C C7 . NAG E 2 . ? 100.230 28.447 57.709 1.00 68.66 ? 533 NAG A C7 1 HETATM 4332 C C8 . NAG E 2 . ? 99.827 29.880 57.506 1.00 69.70 ? 533 NAG A C8 1 HETATM 4333 N N2 . NAG E 2 . ? 99.873 27.489 56.841 1.00 65.81 ? 533 NAG A N2 1 HETATM 4334 O O3 . NAG E 2 . ? 97.461 26.205 56.385 1.00 63.54 ? 533 NAG A O3 1 HETATM 4335 O O4 . NAG E 2 . ? 97.321 24.689 53.894 1.00 70.17 ? 533 NAG A O4 1 HETATM 4336 O O5 . NAG E 2 . ? 99.587 27.531 53.152 1.00 59.88 ? 533 NAG A O5 1 HETATM 4337 O O6 . NAG E 2 . ? 97.531 27.609 51.340 1.00 65.27 ? 533 NAG A O6 1 HETATM 4338 O O7 . NAG E 2 . ? 100.905 28.166 58.706 1.00 70.31 ? 533 NAG A O7 1 HETATM 4339 C C1 . NAG F 2 . ? 95.889 24.732 53.774 1.00 77.30 ? 534 NAG A C1 1 HETATM 4340 C C2 . NAG F 2 . ? 95.375 23.402 53.203 1.00 80.26 ? 534 NAG A C2 1 HETATM 4341 C C3 . NAG F 2 . ? 93.831 23.272 53.217 1.00 80.53 ? 534 NAG A C3 1 HETATM 4342 C C4 . NAG F 2 . ? 93.137 23.966 54.411 1.00 81.17 ? 534 NAG A C4 1 HETATM 4343 C C5 . NAG F 2 . ? 94.126 24.368 55.517 1.00 82.56 ? 534 NAG A C5 1 HETATM 4344 C C6 . NAG F 2 . ? 94.507 23.162 56.414 1.00 83.64 ? 534 NAG A C6 1 HETATM 4345 C C7 . NAG F 2 . ? 97.072 22.392 51.748 1.00 86.23 ? 534 NAG A C7 1 HETATM 4346 C C8 . NAG F 2 . ? 97.490 21.930 50.368 1.00 86.42 ? 534 NAG A C8 1 HETATM 4347 N N2 . NAG F 2 . ? 95.970 23.162 51.887 1.00 82.86 ? 534 NAG A N2 1 HETATM 4348 O O3 . NAG F 2 . ? 93.463 21.911 53.272 1.00 78.97 ? 534 NAG A O3 1 HETATM 4349 O O4 . NAG F 2 . ? 92.409 25.109 54.011 1.00 77.54 ? 534 NAG A O4 1 HETATM 4350 O O5 . NAG F 2 . ? 95.269 25.106 55.007 1.00 81.51 ? 534 NAG A O5 1 HETATM 4351 O O6 . NAG F 2 . ? 95.653 23.443 57.206 1.00 83.37 ? 534 NAG A O6 1 HETATM 4352 O O7 . NAG F 2 . ? 97.766 22.041 52.708 1.00 87.04 ? 534 NAG A O7 1 HETATM 4353 C C1 . NAG G 2 . ? 148.963 19.012 26.666 1.00 68.93 ? 535 NAG A C1 1 HETATM 4354 C C2 . NAG G 2 . ? 149.974 18.721 25.515 1.00 73.12 ? 535 NAG A C2 1 HETATM 4355 C C3 . NAG G 2 . ? 150.175 17.193 25.397 1.00 73.63 ? 535 NAG A C3 1 HETATM 4356 C C4 . NAG G 2 . ? 150.506 16.535 26.748 1.00 74.54 ? 535 NAG A C4 1 HETATM 4357 C C5 . NAG G 2 . ? 149.464 16.952 27.819 1.00 73.82 ? 535 NAG A C5 1 HETATM 4358 C C6 . NAG G 2 . ? 149.760 16.405 29.224 1.00 74.38 ? 535 NAG A C6 1 HETATM 4359 C C7 . NAG G 2 . ? 149.939 20.578 23.746 1.00 73.50 ? 535 NAG A C7 1 HETATM 4360 C C8 . NAG G 2 . ? 150.694 21.571 24.597 1.00 73.55 ? 535 NAG A C8 1 HETATM 4361 N N2 . NAG G 2 . ? 149.614 19.345 24.216 1.00 72.58 ? 535 NAG A N2 1 HETATM 4362 O O3 . NAG G 2 . ? 151.179 16.865 24.458 1.00 74.59 ? 535 NAG A O3 1 HETATM 4363 O O4 . NAG G 2 . ? 150.633 15.133 26.553 1.00 74.81 ? 535 NAG A O4 1 HETATM 4364 O O5 . NAG G 2 . ? 149.382 18.377 27.877 1.00 71.37 ? 535 NAG A O5 1 HETATM 4365 O O6 . NAG G 2 . ? 148.719 16.637 30.167 1.00 74.92 ? 535 NAG A O6 1 HETATM 4366 O O7 . NAG G 2 . ? 149.633 20.948 22.607 1.00 73.89 ? 535 NAG A O7 1 HETATM 4367 C C1 . NAG H 2 . ? 126.541 32.995 9.767 1.00 82.32 ? 536 NAG A C1 1 HETATM 4368 C C2 . NAG H 2 . ? 125.736 33.339 8.517 1.00 86.52 ? 536 NAG A C2 1 HETATM 4369 C C3 . NAG H 2 . ? 126.647 34.181 7.603 1.00 87.08 ? 536 NAG A C3 1 HETATM 4370 C C4 . NAG H 2 . ? 127.003 35.505 8.318 1.00 86.42 ? 536 NAG A C4 1 HETATM 4371 C C5 . NAG H 2 . ? 127.383 35.334 9.804 1.00 85.72 ? 536 NAG A C5 1 HETATM 4372 C C6 . NAG H 2 . ? 127.140 36.658 10.550 1.00 86.02 ? 536 NAG A C6 1 HETATM 4373 C C7 . NAG H 2 . ? 123.741 31.911 8.166 1.00 87.26 ? 536 NAG A C7 1 HETATM 4374 C C8 . NAG H 2 . ? 122.736 33.041 8.240 1.00 86.85 ? 536 NAG A C8 1 HETATM 4375 N N2 . NAG H 2 . ? 125.050 32.180 7.923 1.00 86.20 ? 536 NAG A N2 1 HETATM 4376 O O3 . NAG H 2 . ? 126.018 34.466 6.361 1.00 88.58 ? 536 NAG A O3 1 HETATM 4377 O O4 . NAG H 2 . ? 128.030 36.205 7.639 1.00 85.46 ? 536 NAG A O4 1 HETATM 4378 O O5 . NAG H 2 . ? 126.689 34.252 10.462 1.00 84.89 ? 536 NAG A O5 1 HETATM 4379 O O6 . NAG H 2 . ? 128.234 37.549 10.397 1.00 85.52 ? 536 NAG A O6 1 HETATM 4380 O O7 . NAG H 2 . ? 123.315 30.763 8.323 1.00 87.08 ? 536 NAG A O7 1 HETATM 4381 C C1 . NAG I 2 . ? 142.931 36.388 47.168 1.00 72.77 ? 537 NAG A C1 1 HETATM 4382 C C2 . NAG I 2 . ? 141.931 36.194 46.009 1.00 73.66 ? 537 NAG A C2 1 HETATM 4383 C C3 . NAG I 2 . ? 142.106 37.247 44.884 1.00 75.46 ? 537 NAG A C3 1 HETATM 4384 C C4 . NAG I 2 . ? 142.778 38.589 45.268 0.50 76.53 ? 537 NAG A C4 1 HETATM 4385 C C5 . NAG I 2 . ? 143.619 38.562 46.567 0.50 76.91 ? 537 NAG A C5 1 HETATM 4386 C C6 . NAG I 2 . ? 143.925 39.958 47.136 0.80 78.26 ? 537 NAG A C6 1 HETATM 4387 C C7 . NAG I 2 . ? 141.146 33.832 45.562 1.00 67.05 ? 537 NAG A C7 1 HETATM 4388 C C8 . NAG I 2 . ? 141.270 32.796 44.486 1.00 64.57 ? 537 NAG A C8 1 HETATM 4389 N N2 . NAG I 2 . ? 142.042 34.841 45.471 1.00 69.39 ? 537 NAG A N2 1 HETATM 4390 O O3 . NAG I 2 . ? 140.822 37.562 44.382 1.00 76.63 ? 537 NAG A O3 1 HETATM 4391 O O4 . NAG I 2 . ? 143.555 39.033 44.168 0.50 76.01 ? 537 NAG A O4 1 HETATM 4392 O O5 . NAG I 2 . ? 142.971 37.764 47.554 1.00 76.53 ? 537 NAG A O5 1 HETATM 4393 O O6 . NAG I 2 . ? 143.242 40.166 48.363 0.80 79.35 ? 537 NAG A O6 1 HETATM 4394 O O7 . NAG I 2 . ? 140.272 33.679 46.425 1.00 64.66 ? 537 NAG A O7 1 HETATM 4395 C C1 . NAG J 2 . ? 108.787 -8.841 15.482 1.00 82.02 ? 538 NAG A C1 1 HETATM 4396 C C2 . NAG J 2 . ? 109.485 -10.151 15.099 1.00 81.82 ? 538 NAG A C2 1 HETATM 4397 C C3 . NAG J 2 . ? 110.864 -9.873 14.482 0.50 81.76 ? 538 NAG A C3 1 HETATM 4398 C C4 . NAG J 2 . ? 110.827 -8.783 13.401 0.50 81.14 ? 538 NAG A C4 1 HETATM 4399 C C5 . NAG J 2 . ? 110.030 -7.556 13.851 0.50 80.75 ? 538 NAG A C5 1 HETATM 4400 C C6 . NAG J 2 . ? 109.776 -6.623 12.671 0.50 80.17 ? 538 NAG A C6 1 HETATM 4401 C C7 . NAG J 2 . ? 108.975 -12.154 16.451 1.00 84.20 ? 538 NAG A C7 1 HETATM 4402 C C8 . NAG J 2 . ? 109.673 -13.428 16.035 0.50 83.96 ? 538 NAG A C8 1 HETATM 4403 N N2 . NAG J 2 . ? 109.641 -11.006 16.267 0.50 83.00 ? 538 NAG A N2 1 HETATM 4404 O O3 . NAG J 2 . ? 111.401 -11.066 13.942 0.50 81.50 ? 538 NAG A O3 1 HETATM 4405 O O4 . NAG J 2 . ? 112.143 -8.401 13.053 0.50 80.02 ? 538 NAG A O4 1 HETATM 4406 O O5 . NAG J 2 . ? 108.771 -7.933 14.382 1.00 81.15 ? 538 NAG A O5 1 HETATM 4407 O O6 . NAG J 2 . ? 109.773 -5.295 13.129 0.50 78.69 ? 538 NAG A O6 1 HETATM 4408 O O7 . NAG J 2 . ? 107.847 -12.199 16.953 0.50 83.91 ? 538 NAG A O7 1 HETATM 4409 S S . SO4 K 4 . ? 145.056 9.511 44.244 1.00 61.10 ? 601 SO4 A S 1 HETATM 4410 O O1 . SO4 K 4 . ? 145.787 9.764 43.014 1.00 61.58 ? 601 SO4 A O1 1 HETATM 4411 O O2 . SO4 K 4 . ? 143.605 9.569 43.978 1.00 59.05 ? 601 SO4 A O2 1 HETATM 4412 O O3 . SO4 K 4 . ? 145.415 10.515 45.251 1.00 61.82 ? 601 SO4 A O3 1 HETATM 4413 O O4 . SO4 K 4 . ? 145.490 8.207 44.734 1.00 60.09 ? 601 SO4 A O4 1 HETATM 4414 S S . SO4 L 4 . ? 119.658 2.852 63.724 0.50 47.33 ? 602 SO4 A S 1 HETATM 4415 O O1 . SO4 L 4 . ? 119.758 1.467 63.212 0.50 45.37 ? 602 SO4 A O1 1 HETATM 4416 O O2 . SO4 L 4 . ? 120.714 3.114 64.699 0.50 44.73 ? 602 SO4 A O2 1 HETATM 4417 O O3 . SO4 L 4 . ? 118.326 3.100 64.290 0.50 44.84 ? 602 SO4 A O3 1 HETATM 4418 O O4 . SO4 L 4 . ? 119.857 3.776 62.621 0.50 45.00 ? 602 SO4 A O4 1 HETATM 4419 S S . SO4 M 4 . ? 100.237 8.767 66.529 0.50 55.53 ? 603 SO4 A S 1 HETATM 4420 O O1 . SO4 M 4 . ? 101.708 8.883 66.539 0.50 54.12 ? 603 SO4 A O1 1 HETATM 4421 O O2 . SO4 M 4 . ? 99.765 7.950 65.406 0.50 52.35 ? 603 SO4 A O2 1 HETATM 4422 O O3 . SO4 M 4 . ? 99.674 10.121 66.448 0.50 54.41 ? 603 SO4 A O3 1 HETATM 4423 O O4 . SO4 M 4 . ? 99.807 8.125 67.758 0.50 55.08 ? 603 SO4 A O4 1 HETATM 4424 CL CL . CL N 5 . ? 123.133 21.189 59.478 1.00 74.99 ? 701 CL A CL 1 HETATM 4425 CL CL . CL O 5 . ? 138.782 30.294 54.852 1.00 65.41 ? 702 CL A CL 1 HETATM 4426 CL CL . CL P 5 . ? 101.704 -2.374 55.463 1.00 73.52 ? 703 CL A CL 1 HETATM 4427 C C12 . EFS Q 6 . ? 115.337 13.726 41.651 1.00 34.22 ? 1001 EFS A C12 1 HETATM 4428 C C11 . EFS Q 6 . ? 116.685 14.089 41.068 1.00 34.45 ? 1001 EFS A C11 1 HETATM 4429 O O2 . EFS Q 6 . ? 116.866 15.463 41.363 1.00 35.68 ? 1001 EFS A O2 1 HETATM 4430 P P . EFS Q 6 . ? 117.795 16.511 40.619 1.00 36.68 ? 1001 EFS A P 1 HETATM 4431 O O4 . EFS Q 6 . ? 117.167 17.810 40.949 1.00 36.64 ? 1001 EFS A O4 1 HETATM 4432 O O1 . EFS Q 6 . ? 118.073 16.238 39.136 1.00 34.91 ? 1001 EFS A O1 1 HETATM 4433 C C1 . GOL R 7 . ? 111.486 5.992 41.636 1.00 61.24 ? 604 GOL A C1 1 HETATM 4434 O O1 . GOL R 7 . ? 111.131 7.321 41.386 1.00 63.36 ? 604 GOL A O1 1 HETATM 4435 C C2 . GOL R 7 . ? 112.047 5.440 40.343 1.00 60.21 ? 604 GOL A C2 1 HETATM 4436 O O2 . GOL R 7 . ? 112.169 4.072 40.549 1.00 65.42 ? 604 GOL A O2 1 HETATM 4437 C C3 . GOL R 7 . ? 113.466 5.915 40.054 1.00 60.34 ? 604 GOL A C3 1 HETATM 4438 O O3 . GOL R 7 . ? 113.612 5.857 38.659 1.00 56.67 ? 604 GOL A O3 1 HETATM 4439 C C1 . GOL S 7 . ? 117.670 21.862 40.461 1.00 54.70 ? 605 GOL A C1 1 HETATM 4440 O O1 . GOL S 7 . ? 116.488 22.098 41.185 1.00 57.33 ? 605 GOL A O1 1 HETATM 4441 C C2 . GOL S 7 . ? 117.166 21.601 39.052 1.00 58.85 ? 605 GOL A C2 1 HETATM 4442 O O2 . GOL S 7 . ? 116.371 20.436 38.998 1.00 58.86 ? 605 GOL A O2 1 HETATM 4443 C C3 . GOL S 7 . ? 118.358 21.394 38.156 1.00 60.00 ? 605 GOL A C3 1 HETATM 4444 O O3 . GOL S 7 . ? 119.001 20.200 38.548 1.00 62.77 ? 605 GOL A O3 1 HETATM 4445 C C1 . GOL T 7 . ? 126.565 33.010 27.312 1.00 61.64 ? 606 GOL A C1 1 HETATM 4446 O O1 . GOL T 7 . ? 127.926 32.929 27.671 1.00 60.35 ? 606 GOL A O1 1 HETATM 4447 C C2 . GOL T 7 . ? 126.248 34.474 27.075 1.00 62.95 ? 606 GOL A C2 1 HETATM 4448 O O2 . GOL T 7 . ? 126.230 35.160 28.313 1.00 66.00 ? 606 GOL A O2 1 HETATM 4449 C C3 . GOL T 7 . ? 124.875 34.515 26.444 1.00 66.19 ? 606 GOL A C3 1 HETATM 4450 O O3 . GOL T 7 . ? 125.049 34.342 25.059 1.00 68.43 ? 606 GOL A O3 1 HETATM 4451 C C1 . GOL U 7 . ? 118.639 32.169 42.228 1.00 57.71 ? 607 GOL A C1 1 HETATM 4452 O O1 . GOL U 7 . ? 119.714 32.177 41.346 1.00 57.11 ? 607 GOL A O1 1 HETATM 4453 C C2 . GOL U 7 . ? 118.375 33.569 42.746 1.00 62.60 ? 607 GOL A C2 1 HETATM 4454 O O2 . GOL U 7 . ? 118.738 34.641 41.878 1.00 62.92 ? 607 GOL A O2 1 HETATM 4455 C C3 . GOL U 7 . ? 119.090 33.653 44.075 1.00 62.93 ? 607 GOL A C3 1 HETATM 4456 O O3 . GOL U 7 . ? 120.479 33.651 43.897 1.00 63.13 ? 607 GOL A O3 1 HETATM 4457 O O . HOH V 8 . ? 137.006 16.102 52.600 1.00 35.55 ? 1102 HOH A O 1 HETATM 4458 O O . HOH V 8 . ? 115.949 22.088 48.800 1.00 31.64 ? 1103 HOH A O 1 HETATM 4459 O O . HOH V 8 . ? 119.032 21.593 34.560 1.00 28.29 ? 1104 HOH A O 1 HETATM 4460 O O . HOH V 8 . ? 116.915 3.780 30.762 1.00 35.58 ? 1105 HOH A O 1 HETATM 4461 O O . HOH V 8 . ? 124.925 19.736 30.495 1.00 32.90 ? 1106 HOH A O 1 HETATM 4462 O O . HOH V 8 . ? 121.692 20.993 37.729 1.00 35.69 ? 1107 HOH A O 1 HETATM 4463 O O . HOH V 8 . ? 118.121 15.590 33.918 1.00 34.35 ? 1108 HOH A O 1 HETATM 4464 O O . HOH V 8 . ? 125.819 20.721 46.184 1.00 36.59 ? 1109 HOH A O 1 HETATM 4465 O O . HOH V 8 . ? 111.337 21.470 32.142 1.00 46.17 ? 1110 HOH A O 1 HETATM 4466 O O . HOH V 8 . ? 139.125 12.081 56.056 1.00 38.80 ? 1111 HOH A O 1 HETATM 4467 O O . HOH V 8 . ? 113.945 11.868 19.778 1.00 35.70 ? 1112 HOH A O 1 HETATM 4468 O O . HOH V 8 . ? 117.752 19.910 27.029 1.00 32.24 ? 1113 HOH A O 1 HETATM 4469 O O . HOH V 8 . ? 132.290 -0.582 36.265 1.00 43.46 ? 1114 HOH A O 1 HETATM 4470 O O . HOH V 8 . ? 121.913 6.067 51.713 1.00 33.00 ? 1115 HOH A O 1 HETATM 4471 O O . HOH V 8 . ? 125.589 7.303 54.574 1.00 57.85 ? 1116 HOH A O 1 HETATM 4472 O O . HOH V 8 . ? 122.487 21.140 44.415 1.00 35.95 ? 1117 HOH A O 1 HETATM 4473 O O . HOH V 8 . ? 136.218 14.328 26.851 1.00 32.53 ? 1118 HOH A O 1 HETATM 4474 O O . HOH V 8 . ? 123.297 11.621 46.140 1.00 43.52 ? 1119 HOH A O 1 HETATM 4475 O O . HOH V 8 . ? 122.470 29.323 48.241 1.00 45.05 ? 1120 HOH A O 1 HETATM 4476 O O . HOH V 8 . ? 126.068 25.305 30.397 1.00 35.81 ? 1121 HOH A O 1 HETATM 4477 O O . HOH V 8 . ? 122.619 17.319 16.339 1.00 41.98 ? 1122 HOH A O 1 HETATM 4478 O O . HOH V 8 . ? 113.741 3.890 32.336 1.00 43.20 ? 1123 HOH A O 1 HETATM 4479 O O . HOH V 8 . ? 119.061 17.286 55.570 1.00 31.73 ? 1124 HOH A O 1 HETATM 4480 O O . HOH V 8 . ? 113.970 14.592 25.431 1.00 43.49 ? 1125 HOH A O 1 HETATM 4481 O O . HOH V 8 . ? 136.946 21.972 63.509 1.00 47.04 ? 1126 HOH A O 1 HETATM 4482 O O . HOH V 8 . ? 124.217 28.332 29.879 1.00 42.21 ? 1127 HOH A O 1 HETATM 4483 O O . HOH V 8 . ? 138.481 23.898 61.003 1.00 37.69 ? 1128 HOH A O 1 HETATM 4484 O O . HOH V 8 . ? 118.012 4.155 42.206 1.00 54.73 ? 1129 HOH A O 1 HETATM 4485 O O . HOH V 8 . ? 130.966 30.481 34.530 1.00 42.16 ? 1130 HOH A O 1 HETATM 4486 O O . HOH V 8 . ? 103.278 17.427 55.085 1.00 47.38 ? 1131 HOH A O 1 HETATM 4487 O O . HOH V 8 . ? 111.459 24.420 38.529 1.00 32.82 ? 1132 HOH A O 1 HETATM 4488 O O . HOH V 8 . ? 131.533 13.075 56.970 1.00 35.71 ? 1133 HOH A O 1 HETATM 4489 O O . HOH V 8 . ? 140.367 9.656 49.670 1.00 37.71 ? 1134 HOH A O 1 HETATM 4490 O O . HOH V 8 . ? 111.667 22.046 56.265 1.00 46.51 ? 1135 HOH A O 1 HETATM 4491 O O . HOH V 8 . ? 139.370 4.752 44.775 1.00 47.88 ? 1136 HOH A O 1 HETATM 4492 O O . HOH V 8 . ? 125.938 37.463 52.145 1.00 52.72 ? 1137 HOH A O 1 HETATM 4493 O O . HOH V 8 . ? 119.941 24.743 24.609 1.00 43.88 ? 1138 HOH A O 1 HETATM 4494 O O . HOH V 8 . ? 147.261 29.160 27.380 1.00 53.08 ? 1139 HOH A O 1 HETATM 4495 O O . HOH V 8 . ? 112.894 8.853 45.821 1.00 38.89 ? 1140 HOH A O 1 HETATM 4496 O O . HOH V 8 . ? 121.992 28.219 41.716 1.00 39.95 ? 1141 HOH A O 1 HETATM 4497 O O . HOH V 8 . ? 118.887 24.239 17.087 1.00 54.97 ? 1142 HOH A O 1 HETATM 4498 O O . HOH V 8 . ? 136.300 28.031 49.937 1.00 49.52 ? 1143 HOH A O 1 HETATM 4499 O O . HOH V 8 . ? 122.423 -0.639 24.257 1.00 36.39 ? 1144 HOH A O 1 HETATM 4500 O O . HOH V 8 . ? 115.067 13.948 21.313 1.00 32.11 ? 1145 HOH A O 1 HETATM 4501 O O . HOH V 8 . ? 119.319 6.648 51.128 1.00 38.47 ? 1146 HOH A O 1 HETATM 4502 O O . HOH V 8 . ? 143.080 25.421 50.606 1.00 53.58 ? 1147 HOH A O 1 HETATM 4503 O O . HOH V 8 . ? 121.439 0.695 26.058 1.00 39.26 ? 1148 HOH A O 1 HETATM 4504 O O . HOH V 8 . ? 101.203 24.666 57.517 1.00 48.05 ? 1149 HOH A O 1 HETATM 4505 O O . HOH V 8 . ? 120.017 17.115 17.367 1.00 41.74 ? 1150 HOH A O 1 HETATM 4506 O O . HOH V 8 . ? 144.901 27.849 39.644 1.00 46.22 ? 1151 HOH A O 1 HETATM 4507 O O . HOH V 8 . ? 121.066 10.260 16.246 1.00 48.00 ? 1152 HOH A O 1 HETATM 4508 O O . HOH V 8 . ? 140.970 17.663 34.618 1.00 38.21 ? 1153 HOH A O 1 HETATM 4509 O O . HOH V 8 . ? 128.213 10.098 57.800 1.00 40.66 ? 1154 HOH A O 1 HETATM 4510 O O . HOH V 8 . ? 129.702 16.742 61.488 1.00 39.81 ? 1155 HOH A O 1 HETATM 4511 O O . HOH V 8 . ? 135.175 12.511 64.760 1.00 38.89 ? 1156 HOH A O 1 HETATM 4512 O O . HOH V 8 . ? 130.458 10.467 56.753 1.00 44.44 ? 1157 HOH A O 1 HETATM 4513 O O . HOH V 8 . ? 119.186 8.186 17.599 1.00 46.64 ? 1158 HOH A O 1 HETATM 4514 O O . HOH V 8 . ? 114.754 9.575 21.410 1.00 35.33 ? 1159 HOH A O 1 HETATM 4515 O O . HOH V 8 . ? 137.420 30.622 59.079 1.00 50.74 ? 1160 HOH A O 1 HETATM 4516 O O . HOH V 8 . ? 110.599 12.655 26.642 1.00 44.74 ? 1161 HOH A O 1 HETATM 4517 O O . HOH V 8 . ? 116.350 22.490 34.853 1.00 31.76 ? 1162 HOH A O 1 HETATM 4518 O O . HOH V 8 . ? 106.470 27.171 37.862 1.00 49.96 ? 1163 HOH A O 1 HETATM 4519 O O . HOH V 8 . ? 145.276 28.452 44.870 1.00 37.58 ? 1164 HOH A O 1 HETATM 4520 O O . HOH V 8 . ? 110.523 11.852 15.564 1.00 56.12 ? 1165 HOH A O 1 HETATM 4521 O O . HOH V 8 . ? 126.797 14.443 45.771 1.00 35.85 ? 1166 HOH A O 1 HETATM 4522 O O . HOH V 8 . ? 145.854 26.569 21.002 1.00 57.57 ? 1167 HOH A O 1 HETATM 4523 O O . HOH V 8 . ? 105.980 22.053 62.009 1.00 49.70 ? 1168 HOH A O 1 HETATM 4524 O O . HOH V 8 . ? 104.854 21.356 30.120 1.00 66.17 ? 1169 HOH A O 1 HETATM 4525 O O . HOH V 8 . ? 129.230 41.234 52.387 1.00 44.53 ? 1170 HOH A O 1 HETATM 4526 O O . HOH V 8 . ? 133.623 28.356 53.854 1.00 51.18 ? 1171 HOH A O 1 HETATM 4527 O O . HOH V 8 . ? 137.511 18.828 62.618 1.00 44.53 ? 1172 HOH A O 1 HETATM 4528 O O . HOH V 8 . ? 99.082 11.614 52.118 1.00 52.64 ? 1173 HOH A O 1 HETATM 4529 O O . HOH V 8 . ? 101.473 -2.939 26.312 1.00 64.48 ? 1174 HOH A O 1 HETATM 4530 O O . HOH V 8 . ? 108.709 -9.246 21.111 1.00 60.51 ? 1175 HOH A O 1 HETATM 4531 O O . HOH V 8 . ? 109.374 36.249 40.382 1.00 53.35 ? 1176 HOH A O 1 HETATM 4532 O O . HOH V 8 . ? 133.574 0.073 47.336 1.00 55.47 ? 1177 HOH A O 1 HETATM 4533 O O . HOH V 8 . ? 117.373 18.706 54.160 1.00 47.43 ? 1178 HOH A O 1 HETATM 4534 O O . HOH V 8 . ? 123.180 25.104 22.700 1.00 38.53 ? 1179 HOH A O 1 HETATM 4535 O O . HOH V 8 . ? 117.872 30.534 32.497 1.00 44.57 ? 1180 HOH A O 1 HETATM 4536 O O . HOH V 8 . ? 111.039 2.551 30.635 1.00 46.49 ? 1181 HOH A O 1 HETATM 4537 O O . HOH V 8 . ? 129.053 -0.644 33.787 1.00 56.85 ? 1182 HOH A O 1 HETATM 4538 O O . HOH V 8 . ? 114.332 21.062 36.060 1.00 44.38 ? 1183 HOH A O 1 HETATM 4539 O O . HOH V 8 . ? 139.597 32.700 22.305 1.00 46.39 ? 1184 HOH A O 1 HETATM 4540 O O . HOH V 8 . ? 109.634 4.240 11.704 1.00 56.77 ? 1185 HOH A O 1 HETATM 4541 O O . HOH V 8 . ? 131.777 14.243 64.600 1.00 40.06 ? 1186 HOH A O 1 HETATM 4542 O O . HOH V 8 . ? 105.382 20.847 38.742 1.00 44.47 ? 1187 HOH A O 1 HETATM 4543 O O . HOH V 8 . ? 128.075 20.000 59.285 1.00 56.16 ? 1188 HOH A O 1 HETATM 4544 O O . HOH V 8 . ? 104.584 16.328 69.756 1.00 60.48 ? 1189 HOH A O 1 HETATM 4545 O O . HOH V 8 . ? 119.669 -2.899 26.472 1.00 60.19 ? 1190 HOH A O 1 HETATM 4546 O O . HOH V 8 . ? 121.632 32.313 22.790 1.00 48.60 ? 1191 HOH A O 1 HETATM 4547 O O . HOH V 8 . ? 113.893 15.050 22.723 1.00 40.17 ? 1192 HOH A O 1 HETATM 4548 O O . HOH V 8 . ? 110.787 17.966 17.431 1.00 47.53 ? 1193 HOH A O 1 HETATM 4549 O O . HOH V 8 . ? 110.188 33.986 36.275 1.00 54.35 ? 1194 HOH A O 1 HETATM 4550 O O . HOH V 8 . ? 118.661 32.548 36.792 1.00 49.77 ? 1195 HOH A O 1 HETATM 4551 O O . HOH V 8 . ? 119.245 33.468 39.005 1.00 44.62 ? 1196 HOH A O 1 HETATM 4552 O O . HOH V 8 . ? 109.548 16.050 16.337 1.00 45.96 ? 1197 HOH A O 1 HETATM 4553 O O . HOH V 8 . ? 141.425 35.244 21.708 1.00 61.24 ? 1198 HOH A O 1 HETATM 4554 O O . HOH V 8 . ? 146.550 22.862 33.490 1.00 52.08 ? 1199 HOH A O 1 HETATM 4555 O O . HOH V 8 . ? 146.815 20.424 34.159 1.00 54.81 ? 1200 HOH A O 1 HETATM 4556 O O . HOH V 8 . ? 126.970 -8.604 34.728 1.00 54.30 ? 1201 HOH A O 1 HETATM 4557 O O . HOH V 8 . ? 141.362 17.294 20.998 1.00 54.82 ? 1202 HOH A O 1 HETATM 4558 O O . HOH V 8 . ? 141.060 2.822 36.389 1.00 49.71 ? 1203 HOH A O 1 HETATM 4559 O O . HOH V 8 . ? 117.436 -0.911 40.788 1.00 65.86 ? 1204 HOH A O 1 HETATM 4560 O O . HOH V 8 . ? 127.242 -0.329 46.708 1.00 52.95 ? 1205 HOH A O 1 HETATM 4561 O O . HOH V 8 . ? 136.565 -6.862 43.912 1.00 40.55 ? 1206 HOH A O 1 HETATM 4562 O O . HOH V 8 . ? 108.198 -0.996 52.676 1.00 48.64 ? 1207 HOH A O 1 HETATM 4563 O O . HOH V 8 . ? 119.240 15.528 59.402 1.00 62.76 ? 1208 HOH A O 1 HETATM 4564 O O . HOH V 8 . ? 140.627 -2.551 48.698 1.00 60.37 ? 1209 HOH A O 1 HETATM 4565 O O . HOH V 8 . ? 123.502 31.439 54.766 1.00 44.19 ? 1210 HOH A O 1 HETATM 4566 O O . HOH V 8 . ? 127.871 43.907 50.251 1.00 51.82 ? 1211 HOH A O 1 HETATM 4567 O O . HOH V 8 . ? 141.442 36.877 41.539 1.00 59.70 ? 1212 HOH A O 1 HETATM 4568 O O . HOH V 8 . ? 144.752 15.343 53.844 1.00 43.96 ? 1213 HOH A O 1 HETATM 4569 O O . HOH V 8 . ? 139.144 16.992 61.605 1.00 39.38 ? 1214 HOH A O 1 HETATM 4570 O O . HOH V 8 . ? 127.149 31.410 55.244 1.00 52.76 ? 1215 HOH A O 1 HETATM 4571 O O . HOH V 8 . ? 121.829 1.710 50.991 1.00 58.43 ? 1216 HOH A O 1 HETATM 4572 O O . HOH V 8 . ? 129.326 40.880 25.148 1.00 53.88 ? 1217 HOH A O 1 HETATM 4573 O O . HOH V 8 . ? 120.318 1.996 19.699 1.00 57.76 ? 1218 HOH A O 1 HETATM 4574 O O . HOH V 8 . ? 118.960 -6.105 36.273 1.00 56.82 ? 1219 HOH A O 1 HETATM 4575 O O . HOH V 8 . ? 117.781 15.403 61.627 1.00 44.11 ? 1220 HOH A O 1 HETATM 4576 O O . HOH V 8 . ? 121.022 17.649 59.969 1.00 47.61 ? 1221 HOH A O 1 HETATM 4577 O O . HOH V 8 . ? 144.692 14.596 44.855 1.00 42.02 ? 1222 HOH A O 1 HETATM 4578 O O . HOH V 8 . ? 104.573 26.428 32.775 1.00 66.00 ? 1223 HOH A O 1 HETATM 4579 O O . HOH V 8 . ? 108.895 25.026 22.433 1.00 54.91 ? 1224 HOH A O 1 HETATM 4580 O O . HOH V 8 . ? 122.247 24.554 24.718 1.00 50.15 ? 1225 HOH A O 1 HETATM 4581 O O . HOH V 8 . ? 138.497 -2.151 49.545 1.00 54.50 ? 1226 HOH A O 1 HETATM 4582 O O . HOH V 8 . ? 114.913 7.796 68.572 1.00 53.93 ? 1227 HOH A O 1 HETATM 4583 O O . HOH V 8 . ? 122.186 18.851 13.766 1.00 54.85 ? 1228 HOH A O 1 HETATM 4584 O O . HOH V 8 . ? 115.977 10.655 11.261 1.00 51.57 ? 1229 HOH A O 1 HETATM 4585 O O . HOH V 8 . ? 106.560 12.785 15.257 1.00 55.46 ? 1230 HOH A O 1 HETATM 4586 O O . HOH V 8 . ? 123.417 31.970 11.690 1.00 57.30 ? 1231 HOH A O 1 HETATM 4587 O O . HOH V 8 . ? 117.249 33.117 31.406 1.00 59.63 ? 1232 HOH A O 1 HETATM 4588 O O . HOH V 8 . ? 114.883 20.739 13.585 1.00 54.59 ? 1233 HOH A O 1 HETATM 4589 O O . HOH V 8 . ? 144.141 24.707 31.912 1.00 60.75 ? 1234 HOH A O 1 HETATM 4590 O O . HOH V 8 . ? 111.003 3.598 33.008 1.00 50.75 ? 1235 HOH A O 1 HETATM 4591 O O . HOH V 8 . ? 117.425 34.054 34.064 1.00 64.06 ? 1236 HOH A O 1 HETATM 4592 O O . HOH V 8 . ? 117.823 -0.943 29.591 1.00 50.99 ? 1237 HOH A O 1 HETATM 4593 O O . HOH V 8 . ? 142.452 12.279 21.908 1.00 62.04 ? 1238 HOH A O 1 HETATM 4594 O O . HOH V 8 . ? 136.989 4.075 27.337 1.00 55.93 ? 1239 HOH A O 1 HETATM 4595 O O . HOH V 8 . ? 124.908 3.456 49.267 1.00 64.92 ? 1240 HOH A O 1 HETATM 4596 O O . HOH V 8 . ? 129.915 -6.242 35.035 1.00 52.95 ? 1241 HOH A O 1 HETATM 4597 O O . HOH V 8 . ? 123.125 1.306 44.552 1.00 57.51 ? 1242 HOH A O 1 HETATM 4598 O O . HOH V 8 . ? 134.210 -4.734 36.365 1.00 61.28 ? 1243 HOH A O 1 HETATM 4599 O O . HOH V 8 . ? 116.590 20.724 55.828 1.00 42.55 ? 1244 HOH A O 1 HETATM 4600 O O . HOH V 8 . ? 103.532 26.711 47.753 1.00 58.53 ? 1245 HOH A O 1 HETATM 4601 O O . HOH V 8 . ? 109.777 31.360 57.058 1.00 56.77 ? 1246 HOH A O 1 HETATM 4602 O O . HOH V 8 . ? 98.293 16.025 64.362 1.00 53.70 ? 1247 HOH A O 1 HETATM 4603 O O . HOH V 8 . ? 114.443 20.905 57.046 1.00 43.37 ? 1248 HOH A O 1 HETATM 4604 O O . HOH V 8 . ? 125.879 37.189 37.660 1.00 61.30 ? 1249 HOH A O 1 HETATM 4605 O O . HOH V 8 . ? 145.607 25.926 51.836 1.00 50.10 ? 1250 HOH A O 1 HETATM 4606 O O . HOH V 8 . ? 141.297 11.358 57.626 1.00 42.68 ? 1251 HOH A O 1 HETATM 4607 O O . HOH V 8 . ? 136.511 11.255 62.445 1.00 54.61 ? 1252 HOH A O 1 HETATM 4608 O O . HOH V 8 . ? 144.015 15.254 57.109 1.00 58.67 ? 1253 HOH A O 1 HETATM 4609 O O . HOH V 8 . ? 121.642 13.105 65.662 1.00 70.91 ? 1254 HOH A O 1 HETATM 4610 O O . HOH V 8 . ? 116.953 2.289 50.139 1.00 47.50 ? 1255 HOH A O 1 HETATM 4611 O O . HOH V 8 . ? 132.010 41.491 32.676 1.00 49.13 ? 1256 HOH A O 1 HETATM 4612 O O . HOH V 8 . ? 105.900 28.816 35.033 1.00 57.80 ? 1257 HOH A O 1 HETATM 4613 O O . HOH V 8 . ? 117.486 -4.218 37.788 1.00 61.51 ? 1258 HOH A O 1 HETATM 4614 O O . HOH V 8 . ? 139.579 12.317 63.069 1.00 57.34 ? 1259 HOH A O 1 HETATM 4615 O O . HOH V 8 . ? 129.296 9.007 64.800 1.00 53.01 ? 1260 HOH A O 1 HETATM 4616 O O . HOH V 8 . ? 116.219 22.848 13.728 1.00 61.20 ? 1261 HOH A O 1 HETATM 4617 O O . HOH V 8 . ? 119.559 33.761 30.313 1.00 58.06 ? 1262 HOH A O 1 HETATM 4618 O O . HOH V 8 . ? 110.946 23.314 17.721 1.00 62.36 ? 1263 HOH A O 1 HETATM 4619 O O . HOH V 8 . ? 120.979 -0.633 41.510 1.00 70.58 ? 1264 HOH A O 1 HETATM 4620 O O . HOH V 8 . ? 127.921 -0.684 48.939 1.00 61.39 ? 1265 HOH A O 1 HETATM 4621 O O . HOH V 8 . ? 112.589 8.319 9.582 1.00 60.72 ? 1266 HOH A O 1 HETATM 4622 O O . HOH V 8 . ? 109.468 11.797 36.778 1.00 56.97 ? 1267 HOH A O 1 HETATM 4623 O O . HOH V 8 . ? 111.989 8.758 43.031 1.00 45.24 ? 1268 HOH A O 1 HETATM 4624 O O . HOH V 8 . ? 144.292 41.401 42.121 1.00 72.30 ? 1269 HOH A O 1 HETATM 4625 O O . HOH V 8 . ? 99.855 11.721 19.030 1.00 64.74 ? 1270 HOH A O 1 HETATM 4626 O O . HOH V 8 . ? 116.842 21.588 60.008 1.00 58.65 ? 1271 HOH A O 1 HETATM 4627 O O . HOH V 8 . ? 118.384 34.560 51.329 1.00 65.23 ? 1272 HOH A O 1 HETATM 4628 O O . HOH V 8 . ? 133.052 35.246 52.153 1.00 51.54 ? 1273 HOH A O 1 HETATM 4629 O O . HOH V 8 . ? 138.062 28.646 51.936 1.00 49.66 ? 1274 HOH A O 1 HETATM 4630 O O . HOH V 8 . ? 134.092 10.541 65.083 1.00 62.57 ? 1275 HOH A O 1 HETATM 4631 O O . HOH V 8 . ? 140.999 -0.423 38.888 1.00 60.22 ? 1276 HOH A O 1 HETATM 4632 O O . HOH V 8 . ? 140.372 41.364 24.807 1.00 72.77 ? 1277 HOH A O 1 HETATM 4633 O O . HOH V 8 . ? 152.722 11.203 26.252 1.00 60.29 ? 1278 HOH A O 1 HETATM 4634 O O . HOH V 8 . ? 143.881 15.881 20.133 1.00 53.84 ? 1279 HOH A O 1 HETATM 4635 O O . HOH V 8 . ? 144.463 20.536 17.162 1.00 63.13 ? 1280 HOH A O 1 HETATM 4636 O O . HOH V 8 . ? 116.651 -3.196 32.765 1.00 66.97 ? 1281 HOH A O 1 HETATM 4637 O O . HOH V 8 . ? 98.647 31.259 55.065 1.00 52.27 ? 1282 HOH A O 1 HETATM 4638 O O . HOH V 8 . ? 115.139 12.857 66.569 1.00 78.14 ? 1283 HOH A O 1 HETATM 4639 O O . HOH V 8 . ? 125.246 0.977 18.705 1.00 60.64 ? 1284 HOH A O 1 HETATM 4640 O O . HOH V 8 . ? 124.342 -8.984 34.845 1.00 62.83 ? 1285 HOH A O 1 HETATM 4641 O O . HOH V 8 . ? 122.890 4.317 50.015 0.50 42.06 ? 1286 HOH A O 1 HETATM 4642 O O . HOH V 8 . ? 107.027 1.412 37.897 1.00 48.66 ? 1287 HOH A O 1 HETATM 4643 O O . HOH V 8 . ? 104.051 17.488 19.170 1.00 68.82 ? 1288 HOH A O 1 HETATM 4644 O O . HOH V 8 . ? 118.390 10.969 63.115 1.00 72.10 ? 1289 HOH A O 1 HETATM 4645 O O . HOH V 8 . ? 100.335 -2.965 28.964 1.00 75.01 ? 1290 HOH A O 1 HETATM 4646 O O . HOH V 8 . ? 141.306 4.849 55.856 1.00 56.87 ? 1291 HOH A O 1 HETATM 4647 O O . HOH V 8 . ? 125.128 12.136 63.426 1.00 76.58 ? 1292 HOH A O 1 HETATM 4648 O O . HOH V 8 . ? 113.846 0.575 63.265 0.50 48.79 ? 1293 HOH A O 1 HETATM 4649 O O . HOH V 8 . ? 123.064 27.309 17.598 1.00 68.19 ? 1294 HOH A O 1 HETATM 4650 O O . HOH V 8 . ? 120.276 25.122 15.524 1.00 65.87 ? 1295 HOH A O 1 HETATM 4651 O O . HOH V 8 . ? 116.534 36.255 42.502 1.00 65.96 ? 1296 HOH A O 1 HETATM 4652 O O . HOH V 8 . ? 126.270 38.308 31.824 1.00 67.47 ? 1297 HOH A O 1 HETATM 4653 O O . HOH V 8 . ? 142.375 13.157 55.960 1.00 50.60 ? 1298 HOH A O 1 HETATM 4654 O O . HOH V 8 . ? 108.491 33.263 48.334 1.00 49.86 ? 1299 HOH A O 1 HETATM 4655 O O . HOH V 8 . ? 110.944 14.217 28.601 1.00 54.04 ? 1300 HOH A O 1 HETATM 4656 O O . HOH V 8 . ? 127.248 7.389 22.829 1.00 56.48 ? 1301 HOH A O 1 HETATM 4657 O O . HOH V 8 . ? 117.662 -1.428 35.700 1.00 44.02 ? 1302 HOH A O 1 HETATM 4658 O O . HOH V 8 . ? 103.164 10.721 46.110 1.00 56.31 ? 1303 HOH A O 1 HETATM 4659 O O . HOH V 8 . ? 102.779 20.973 48.806 1.00 52.97 ? 1304 HOH A O 1 HETATM 4660 O O . HOH V 8 . ? 102.860 7.987 57.744 1.00 67.77 ? 1305 HOH A O 1 HETATM 4661 O O . HOH V 8 . ? 99.383 4.080 53.246 1.00 59.35 ? 1306 HOH A O 1 HETATM 4662 O O . HOH V 8 . ? 118.050 4.234 52.163 1.00 44.69 ? 1307 HOH A O 1 HETATM 4663 O O . HOH V 8 . ? 119.588 5.236 48.619 1.00 54.22 ? 1308 HOH A O 1 HETATM 4664 O O . HOH V 8 . ? 114.527 18.069 40.345 1.00 51.54 ? 1309 HOH A O 1 HETATM 4665 O O . HOH V 8 . ? 118.861 29.913 35.278 1.00 50.63 ? 1310 HOH A O 1 HETATM 4666 O O . HOH V 8 . ? 111.486 10.527 49.023 1.00 59.56 ? 1311 HOH A O 1 HETATM 4667 O O . HOH V 8 . ? 110.025 6.823 47.412 1.00 57.14 ? 1312 HOH A O 1 HETATM 4668 O O . HOH V 8 . ? 112.181 14.822 39.861 1.00 64.85 ? 1313 HOH A O 1 HETATM 4669 O O . HOH V 8 . ? 141.885 25.354 14.608 1.00 52.26 ? 1314 HOH A O 1 HETATM 4670 O O . HOH V 8 . ? 139.663 14.975 63.279 0.50 44.24 ? 1315 HOH A O 1 HETATM 4671 O O . HOH V 8 . ? 115.918 27.272 20.015 1.00 49.86 ? 1316 HOH A O 1 HETATM 4672 O O . HOH V 8 . ? 135.130 31.468 53.207 1.00 57.21 ? 1317 HOH A O 1 HETATM 4673 O O . HOH V 8 . ? 144.625 30.923 44.955 1.00 39.31 ? 1318 HOH A O 1 HETATM 4674 O O . HOH V 8 . ? 112.805 33.358 35.327 1.00 55.58 ? 1319 HOH A O 1 HETATM 4675 O O . HOH V 8 . ? 130.208 12.639 6.605 1.00 84.39 ? 1320 HOH A O 1 HETATM 4676 O O . HOH V 8 . ? 125.344 16.269 60.981 1.00 67.36 ? 1321 HOH A O 1 # loop_ _pdbx_poly_seq_scheme.asym_id _pdbx_poly_seq_scheme.entity_id _pdbx_poly_seq_scheme.seq_id _pdbx_poly_seq_scheme.mon_id _pdbx_poly_seq_scheme.ndb_seq_num _pdbx_poly_seq_scheme.pdb_seq_num _pdbx_poly_seq_scheme.auth_seq_num _pdbx_poly_seq_scheme.pdb_mon_id _pdbx_poly_seq_scheme.auth_mon_id _pdbx_poly_seq_scheme.pdb_strand_id _pdbx_poly_seq_scheme.pdb_ins_code _pdbx_poly_seq_scheme.hetero A 1 1 GLU 1 1 ? ? ? A . n A 1 2 ASP 2 2 ? ? ? A . n A 1 3 ASP 3 3 ? ? ? A . n A 1 4 ILE 4 4 4 ILE ILE A . n A 1 5 ILE 5 5 5 ILE ILE A . n A 1 6 ILE 6 6 6 ILE ILE A . n A 1 7 ALA 7 7 7 ALA ALA A . n A 1 8 THR 8 8 8 THR THR A . n A 1 9 LYS 9 9 9 LYS LYS A . n A 1 10 ASN 10 10 10 ASN ASN A . n A 1 11 GLY 11 11 11 GLY GLY A . n A 1 12 LYS 12 12 12 LYS LYS A . n A 1 13 VAL 13 13 13 VAL VAL A . n A 1 14 ARG 14 14 14 ARG ARG A . n A 1 15 GLY 15 15 15 GLY GLY A . n A 1 16 MET 16 16 16 MET MET A . n A 1 17 GLN 17 17 17 GLN GLN A . n A 1 18 LEU 18 18 18 LEU LEU A . n A 1 19 THR 19 19 19 THR THR A . n A 1 20 VAL 20 20 20 VAL VAL A . n A 1 21 PHE 21 21 21 PHE PHE A . n A 1 22 GLY 22 22 22 GLY GLY A . n A 1 23 GLY 23 23 23 GLY GLY A . n A 1 24 THR 24 24 24 THR THR A . n A 1 25 VAL 25 25 25 VAL VAL A . n A 1 26 THR 26 26 26 THR THR A . n A 1 27 ALA 27 27 27 ALA ALA A . n A 1 28 PHE 28 28 28 PHE PHE A . n A 1 29 LEU 29 29 29 LEU LEU A . n A 1 30 GLY 30 30 30 GLY GLY A . n A 1 31 ILE 31 31 31 ILE ILE A . n A 1 32 PRO 32 32 32 PRO PRO A . n A 1 33 TYR 33 33 33 TYR TYR A . n A 1 34 ALA 34 34 34 ALA ALA A . n A 1 35 GLN 35 35 35 GLN GLN A . n A 1 36 PRO 36 36 36 PRO PRO A . n A 1 37 PRO 37 37 37 PRO PRO A . n A 1 38 LEU 38 38 38 LEU LEU A . n A 1 39 GLY 39 39 39 GLY GLY A . n A 1 40 ARG 40 40 40 ARG ARG A . n A 1 41 LEU 41 41 41 LEU LEU A . n A 1 42 ARG 42 42 42 ARG ARG A . n A 1 43 PHE 43 43 43 PHE PHE A . n A 1 44 LYS 44 44 44 LYS LYS A . n A 1 45 LYS 45 45 45 LYS LYS A . n A 1 46 PRO 46 46 46 PRO PRO A . n A 1 47 GLN 47 47 47 GLN GLN A . n A 1 48 SER 48 48 48 SER SER A . n A 1 49 LEU 49 49 49 LEU LEU A . n A 1 50 THR 50 50 50 THR THR A . n A 1 51 LYS 51 51 51 LYS LYS A . n A 1 52 TRP 52 52 52 TRP TRP A . n A 1 53 SER 53 53 53 SER SER A . n A 1 54 ASP 54 54 54 ASP ASP A . n A 1 55 ILE 55 55 55 ILE ILE A . n A 1 56 TRP 56 56 56 TRP TRP A . n A 1 57 ASN 57 57 57 ASN ASN A . n A 1 58 ALA 58 58 58 ALA ALA A . n A 1 59 THR 59 59 59 THR THR A . n A 1 60 LYS 60 60 60 LYS LYS A . n A 1 61 TYR 61 61 61 TYR TYR A . n A 1 62 ALA 62 62 62 ALA ALA A . n A 1 63 ASN 63 63 63 ASN ASN A . n A 1 64 SER 64 64 64 SER SER A . n A 1 65 CYS 65 65 65 CYS CYS A . n A 1 66 CSS 66 66 66 CSS CYS A . n A 1 67 GLN 67 67 67 GLN GLN A . n A 1 68 ASN 68 68 68 ASN ASN A . n A 1 69 ILE 69 69 69 ILE ILE A . n A 1 70 ASP 70 70 70 ASP ASP A . n A 1 71 GLN 71 71 71 GLN GLN A . n A 1 72 SER 72 72 72 SER SER A . n A 1 73 PHE 73 73 73 PHE PHE A . n A 1 74 PRO 74 74 74 PRO PRO A . n A 1 75 GLY 75 75 75 GLY GLY A . n A 1 76 PHE 76 76 76 PHE PHE A . n A 1 77 HIS 77 77 77 HIS HIS A . n A 1 78 GLY 78 78 78 GLY GLY A . n A 1 79 SER 79 79 79 SER SER A . n A 1 80 GLU 80 80 80 GLU GLU A . n A 1 81 MET 81 81 81 MET MET A . n A 1 82 TRP 82 82 82 TRP TRP A . n A 1 83 ASN 83 83 83 ASN ASN A . n A 1 84 PRO 84 84 84 PRO PRO A . n A 1 85 ASN 85 85 85 ASN ASN A . n A 1 86 THR 86 86 86 THR THR A . n A 1 87 ASP 87 87 87 ASP ASP A . n A 1 88 LEU 88 88 88 LEU LEU A . n A 1 89 SER 89 89 89 SER SER A . n A 1 90 GLU 90 90 90 GLU GLU A . n A 1 91 ASP 91 91 91 ASP ASP A . n A 1 92 CYS 92 92 92 CYS CYS A . n A 1 93 LEU 93 93 93 LEU LEU A . n A 1 94 TYR 94 94 94 TYR TYR A . n A 1 95 LEU 95 95 95 LEU LEU A . n A 1 96 ASN 96 96 96 ASN ASN A . n A 1 97 VAL 97 97 97 VAL VAL A . n A 1 98 TRP 98 98 98 TRP TRP A . n A 1 99 ILE 99 99 99 ILE ILE A . n A 1 100 PRO 100 100 100 PRO PRO A . n A 1 101 ALA 101 101 101 ALA ALA A . n A 1 102 PRO 102 102 102 PRO PRO A . n A 1 103 LYS 103 103 103 LYS LYS A . n A 1 104 PRO 104 104 104 PRO PRO A . n A 1 105 LYS 105 105 105 LYS LYS A . n A 1 106 ASN 106 106 106 ASN ASN A . n A 1 107 ALA 107 107 107 ALA ALA A . n A 1 108 THR 108 108 108 THR THR A . n A 1 109 VAL 109 109 109 VAL VAL A . n A 1 110 LEU 110 110 110 LEU LEU A . n A 1 111 ILE 111 111 111 ILE ILE A . n A 1 112 TRP 112 112 112 TRP TRP A . n A 1 113 ILE 113 113 113 ILE ILE A . n A 1 114 TYR 114 114 114 TYR TYR A . n A 1 115 GLY 115 115 115 GLY GLY A . n A 1 116 GLY 116 116 116 GLY GLY A . n A 1 117 GLY 117 117 117 GLY GLY A . n A 1 118 PHE 118 118 118 PHE PHE A . n A 1 119 GLN 119 119 119 GLN GLN A . n A 1 120 THR 120 120 120 THR THR A . n A 1 121 GLY 121 121 121 GLY GLY A . n A 1 122 THR 122 122 122 THR THR A . n A 1 123 SER 123 123 123 SER SER A . n A 1 124 SER 124 124 124 SER SER A . n A 1 125 LEU 125 125 125 LEU LEU A . n A 1 126 HIS 126 126 126 HIS HIS A . n A 1 127 VAL 127 127 127 VAL VAL A . n A 1 128 TYR 128 128 128 TYR TYR A . n A 1 129 ASP 129 129 129 ASP ASP A . n A 1 130 GLY 130 130 130 GLY GLY A . n A 1 131 LYS 131 131 131 LYS LYS A . n A 1 132 PHE 132 132 132 PHE PHE A . n A 1 133 LEU 133 133 133 LEU LEU A . n A 1 134 ALA 134 134 134 ALA ALA A . n A 1 135 ARG 135 135 135 ARG ARG A . n A 1 136 VAL 136 136 136 VAL VAL A . n A 1 137 GLU 137 137 137 GLU GLU A . n A 1 138 ARG 138 138 138 ARG ARG A . n A 1 139 VAL 139 139 139 VAL VAL A . n A 1 140 ILE 140 140 140 ILE ILE A . n A 1 141 VAL 141 141 141 VAL VAL A . n A 1 142 VAL 142 142 142 VAL VAL A . n A 1 143 SER 143 143 143 SER SER A . n A 1 144 MET 144 144 144 MET MET A . n A 1 145 ASN 145 145 145 ASN ASN A . n A 1 146 TYR 146 146 146 TYR TYR A . n A 1 147 ARG 147 147 147 ARG ARG A . n A 1 148 VAL 148 148 148 VAL VAL A . n A 1 149 GLY 149 149 149 GLY GLY A . n A 1 150 ALA 150 150 150 ALA ALA A . n A 1 151 LEU 151 151 151 LEU LEU A . n A 1 152 GLY 152 152 152 GLY GLY A . n A 1 153 PHE 153 153 153 PHE PHE A . n A 1 154 LEU 154 154 154 LEU LEU A . n A 1 155 ALA 155 155 155 ALA ALA A . n A 1 156 LEU 156 156 156 LEU LEU A . n A 1 157 PRO 157 157 157 PRO PRO A . n A 1 158 GLY 158 158 158 GLY GLY A . n A 1 159 ASN 159 159 159 ASN ASN A . n A 1 160 PRO 160 160 160 PRO PRO A . n A 1 161 GLU 161 161 161 GLU GLU A . n A 1 162 ALA 162 162 162 ALA ALA A . n A 1 163 PRO 163 163 163 PRO PRO A . n A 1 164 GLY 164 164 164 GLY GLY A . n A 1 165 ASN 165 165 165 ASN ASN A . n A 1 166 MET 166 166 166 MET MET A . n A 1 167 GLY 167 167 167 GLY GLY A . n A 1 168 LEU 168 168 168 LEU LEU A . n A 1 169 PHE 169 169 169 PHE PHE A . n A 1 170 ASP 170 170 170 ASP ASP A . n A 1 171 GLN 171 171 171 GLN GLN A . n A 1 172 GLN 172 172 172 GLN GLN A . n A 1 173 LEU 173 173 173 LEU LEU A . n A 1 174 ALA 174 174 174 ALA ALA A . n A 1 175 LEU 175 175 175 LEU LEU A . n A 1 176 GLN 176 176 176 GLN GLN A . n A 1 177 TRP 177 177 177 TRP TRP A . n A 1 178 VAL 178 178 178 VAL VAL A . n A 1 179 GLN 179 179 179 GLN GLN A . n A 1 180 LYS 180 180 180 LYS LYS A . n A 1 181 ASN 181 181 181 ASN ASN A . n A 1 182 ILE 182 182 182 ILE ILE A . n A 1 183 ALA 183 183 183 ALA ALA A . n A 1 184 ALA 184 184 184 ALA ALA A . n A 1 185 PHE 185 185 185 PHE PHE A . n A 1 186 GLY 186 186 186 GLY GLY A . n A 1 187 GLY 187 187 187 GLY GLY A . n A 1 188 ASN 188 188 188 ASN ASN A . n A 1 189 PRO 189 189 189 PRO PRO A . n A 1 190 LYS 190 190 190 LYS LYS A . n A 1 191 SER 191 191 191 SER SER A . n A 1 192 VAL 192 192 192 VAL VAL A . n A 1 193 THR 193 193 193 THR THR A . n A 1 194 LEU 194 194 194 LEU LEU A . n A 1 195 PHE 195 195 195 PHE PHE A . n A 1 196 GLY 196 196 196 GLY GLY A . n A 1 197 GLU 197 197 197 GLU GLU A . n A 1 198 SER 198 198 198 SER SER A . n A 1 199 ALA 199 199 199 ALA ALA A . n A 1 200 GLY 200 200 200 GLY GLY A . n A 1 201 ALA 201 201 201 ALA ALA A . n A 1 202 ALA 202 202 202 ALA ALA A . n A 1 203 SER 203 203 203 SER SER A . n A 1 204 VAL 204 204 204 VAL VAL A . n A 1 205 SER 205 205 205 SER SER A . n A 1 206 LEU 206 206 206 LEU LEU A . n A 1 207 HIS 207 207 207 HIS HIS A . n A 1 208 LEU 208 208 208 LEU LEU A . n A 1 209 LEU 209 209 209 LEU LEU A . n A 1 210 SER 210 210 210 SER SER A . n A 1 211 PRO 211 211 211 PRO PRO A . n A 1 212 GLY 212 212 212 GLY GLY A . n A 1 213 SER 213 213 213 SER SER A . n A 1 214 HIS 214 214 214 HIS HIS A . n A 1 215 SER 215 215 215 SER SER A . n A 1 216 LEU 216 216 216 LEU LEU A . n A 1 217 PHE 217 217 217 PHE PHE A . n A 1 218 THR 218 218 218 THR THR A . n A 1 219 ARG 219 219 219 ARG ARG A . n A 1 220 ALA 220 220 220 ALA ALA A . n A 1 221 ILE 221 221 221 ILE ILE A . n A 1 222 LEU 222 222 222 LEU LEU A . n A 1 223 GLN 223 223 223 GLN GLN A . n A 1 224 SER 224 224 224 SER SER A . n A 1 225 GLY 225 225 225 GLY GLY A . n A 1 226 SER 226 226 226 SER SER A . n A 1 227 PHE 227 227 227 PHE PHE A . n A 1 228 ASN 228 228 228 ASN ASN A . n A 1 229 ALA 229 229 229 ALA ALA A . n A 1 230 PRO 230 230 230 PRO PRO A . n A 1 231 TRP 231 231 231 TRP TRP A . n A 1 232 ALA 232 232 232 ALA ALA A . n A 1 233 VAL 233 233 233 VAL VAL A . n A 1 234 THR 234 234 234 THR THR A . n A 1 235 SER 235 235 235 SER SER A . n A 1 236 LEU 236 236 236 LEU LEU A . n A 1 237 TYR 237 237 237 TYR TYR A . n A 1 238 GLU 238 238 238 GLU GLU A . n A 1 239 ALA 239 239 239 ALA ALA A . n A 1 240 ARG 240 240 240 ARG ARG A . n A 1 241 ASN 241 241 241 ASN ASN A . n A 1 242 ARG 242 242 242 ARG ARG A . n A 1 243 THR 243 243 243 THR THR A . n A 1 244 LEU 244 244 244 LEU LEU A . n A 1 245 ASN 245 245 245 ASN ASN A . n A 1 246 LEU 246 246 246 LEU LEU A . n A 1 247 ALA 247 247 247 ALA ALA A . n A 1 248 LYS 248 248 248 LYS LYS A . n A 1 249 LEU 249 249 249 LEU LEU A . n A 1 250 THR 250 250 250 THR THR A . n A 1 251 GLY 251 251 251 GLY GLY A . n A 1 252 CYS 252 252 252 CYS CYS A . n A 1 253 SER 253 253 253 SER SER A . n A 1 254 ARG 254 254 254 ARG ARG A . n A 1 255 GLU 255 255 255 GLU GLU A . n A 1 256 ASN 256 256 256 ASN ASN A . n A 1 257 GLU 257 257 257 GLU GLU A . n A 1 258 THR 258 258 258 THR THR A . n A 1 259 GLU 259 259 259 GLU GLU A . n A 1 260 ILE 260 260 260 ILE ILE A . n A 1 261 ILE 261 261 261 ILE ILE A . n A 1 262 LYS 262 262 262 LYS LYS A . n A 1 263 CYS 263 263 263 CYS CYS A . n A 1 264 LEU 264 264 264 LEU LEU A . n A 1 265 ARG 265 265 265 ARG ARG A . n A 1 266 ASN 266 266 266 ASN ASN A . n A 1 267 LYS 267 267 267 LYS LYS A . n A 1 268 ASP 268 268 268 ASP ASP A . n A 1 269 PRO 269 269 269 PRO PRO A . n A 1 270 GLN 270 270 270 GLN GLN A . n A 1 271 GLU 271 271 271 GLU GLU A . n A 1 272 ILE 272 272 272 ILE ILE A . n A 1 273 LEU 273 273 273 LEU LEU A . n A 1 274 LEU 274 274 274 LEU LEU A . n A 1 275 ASN 275 275 275 ASN ASN A . n A 1 276 GLU 276 276 276 GLU GLU A . n A 1 277 ALA 277 277 277 ALA ALA A . n A 1 278 PHE 278 278 278 PHE PHE A . n A 1 279 VAL 279 279 279 VAL VAL A . n A 1 280 VAL 280 280 280 VAL VAL A . n A 1 281 PRO 281 281 281 PRO PRO A . n A 1 282 TYR 282 282 282 TYR TYR A . n A 1 283 GLY 283 283 283 GLY GLY A . n A 1 284 THR 284 284 284 THR THR A . n A 1 285 PRO 285 285 285 PRO PRO A . n A 1 286 LEU 286 286 286 LEU LEU A . n A 1 287 SER 287 287 287 SER SER A . n A 1 288 VAL 288 288 288 VAL VAL A . n A 1 289 ASN 289 289 289 ASN ASN A . n A 1 290 PHE 290 290 290 PHE PHE A . n A 1 291 GLY 291 291 291 GLY GLY A . n A 1 292 PRO 292 292 292 PRO PRO A . n A 1 293 THR 293 293 293 THR THR A . n A 1 294 VAL 294 294 294 VAL VAL A . n A 1 295 ASP 295 295 295 ASP ASP A . n A 1 296 GLY 296 296 296 GLY GLY A . n A 1 297 ASP 297 297 297 ASP ASP A . n A 1 298 PHE 298 298 298 PHE PHE A . n A 1 299 LEU 299 299 299 LEU LEU A . n A 1 300 THR 300 300 300 THR THR A . n A 1 301 ASP 301 301 301 ASP ASP A . n A 1 302 MET 302 302 302 MET MET A . n A 1 303 PRO 303 303 303 PRO PRO A . n A 1 304 ASP 304 304 304 ASP ASP A . n A 1 305 ILE 305 305 305 ILE ILE A . n A 1 306 LEU 306 306 306 LEU LEU A . n A 1 307 LEU 307 307 307 LEU LEU A . n A 1 308 GLU 308 308 308 GLU GLU A . n A 1 309 LEU 309 309 309 LEU LEU A . n A 1 310 GLY 310 310 310 GLY GLY A . n A 1 311 GLN 311 311 311 GLN GLN A . n A 1 312 PHE 312 312 312 PHE PHE A . n A 1 313 LYS 313 313 313 LYS LYS A . n A 1 314 LYS 314 314 314 LYS LYS A . n A 1 315 THR 315 315 315 THR THR A . n A 1 316 GLN 316 316 316 GLN GLN A . n A 1 317 ILE 317 317 317 ILE ILE A . n A 1 318 LEU 318 318 318 LEU LEU A . n A 1 319 VAL 319 319 319 VAL VAL A . n A 1 320 GLY 320 320 320 GLY GLY A . n A 1 321 VAL 321 321 321 VAL VAL A . n A 1 322 ASN 322 322 322 ASN ASN A . n A 1 323 LYS 323 323 323 LYS LYS A . n A 1 324 ASP 324 324 324 ASP ASP A . n A 1 325 GLU 325 325 325 GLU GLU A . n A 1 326 GLY 326 326 326 GLY GLY A . n A 1 327 THR 327 327 327 THR THR A . n A 1 328 ALA 328 328 328 ALA ALA A . n A 1 329 PHE 329 329 329 PHE PHE A . n A 1 330 LEU 330 330 330 LEU LEU A . n A 1 331 VAL 331 331 331 VAL VAL A . n A 1 332 TYR 332 332 332 TYR TYR A . n A 1 333 GLY 333 333 333 GLY GLY A . n A 1 334 ALA 334 334 334 ALA ALA A . n A 1 335 PRO 335 335 335 PRO PRO A . n A 1 336 GLY 336 336 336 GLY GLY A . n A 1 337 PHE 337 337 337 PHE PHE A . n A 1 338 SER 338 338 338 SER SER A . n A 1 339 LYS 339 339 339 LYS LYS A . n A 1 340 ASP 340 340 340 ASP ASP A . n A 1 341 ASN 341 341 341 ASN ASN A . n A 1 342 ASN 342 342 342 ASN ASN A . n A 1 343 SER 343 343 343 SER SER A . n A 1 344 ILE 344 344 344 ILE ILE A . n A 1 345 ILE 345 345 345 ILE ILE A . n A 1 346 THR 346 346 346 THR THR A . n A 1 347 ARG 347 347 347 ARG ARG A . n A 1 348 LYS 348 348 348 LYS LYS A . n A 1 349 GLU 349 349 349 GLU GLU A . n A 1 350 PHE 350 350 350 PHE PHE A . n A 1 351 GLN 351 351 351 GLN GLN A . n A 1 352 GLU 352 352 352 GLU GLU A . n A 1 353 GLY 353 353 353 GLY GLY A . n A 1 354 LEU 354 354 354 LEU LEU A . n A 1 355 LYS 355 355 355 LYS LYS A . n A 1 356 ILE 356 356 356 ILE ILE A . n A 1 357 PHE 357 357 357 PHE PHE A . n A 1 358 PHE 358 358 358 PHE PHE A . n A 1 359 PRO 359 359 359 PRO PRO A . n A 1 360 GLY 360 360 360 GLY GLY A . n A 1 361 VAL 361 361 361 VAL VAL A . n A 1 362 SER 362 362 362 SER SER A . n A 1 363 GLU 363 363 363 GLU GLU A . n A 1 364 PHE 364 364 364 PHE PHE A . n A 1 365 GLY 365 365 365 GLY GLY A . n A 1 366 LYS 366 366 366 LYS LYS A . n A 1 367 GLU 367 367 367 GLU GLU A . n A 1 368 SER 368 368 368 SER SER A . n A 1 369 ILE 369 369 369 ILE ILE A . n A 1 370 LEU 370 370 370 LEU LEU A . n A 1 371 PHE 371 371 371 PHE PHE A . n A 1 372 HIS 372 372 372 HIS HIS A . n A 1 373 TYR 373 373 373 TYR TYR A . n A 1 374 THR 374 374 374 THR THR A . n A 1 375 ASP 375 375 375 ASP ASP A . n A 1 376 TRP 376 376 376 TRP TRP A . n A 1 377 VAL 377 377 377 VAL VAL A . n A 1 378 ASP 378 378 ? ? ? A . n A 1 379 ASP 379 379 ? ? ? A . n A 1 380 GLN 380 380 380 GLN GLN A . n A 1 381 ARG 381 381 381 ARG ARG A . n A 1 382 PRO 382 382 382 PRO PRO A . n A 1 383 GLU 383 383 383 GLU GLU A . n A 1 384 ASN 384 384 384 ASN ASN A . n A 1 385 TYR 385 385 385 TYR TYR A . n A 1 386 ARG 386 386 386 ARG ARG A . n A 1 387 GLU 387 387 387 GLU GLU A . n A 1 388 ALA 388 388 388 ALA ALA A . n A 1 389 LEU 389 389 389 LEU LEU A . n A 1 390 GLY 390 390 390 GLY GLY A . n A 1 391 ASP 391 391 391 ASP ASP A . n A 1 392 VAL 392 392 392 VAL VAL A . n A 1 393 VAL 393 393 393 VAL VAL A . n A 1 394 GLY 394 394 394 GLY GLY A . n A 1 395 ASP 395 395 395 ASP ASP A . n A 1 396 TYR 396 396 396 TYR TYR A . n A 1 397 ASN 397 397 397 ASN ASN A . n A 1 398 PHE 398 398 398 PHE PHE A . n A 1 399 ILE 399 399 399 ILE ILE A . n A 1 400 CYS 400 400 400 CYS CYS A . n A 1 401 PRO 401 401 401 PRO PRO A . n A 1 402 ALA 402 402 402 ALA ALA A . n A 1 403 LEU 403 403 403 LEU LEU A . n A 1 404 GLU 404 404 404 GLU GLU A . n A 1 405 PHE 405 405 405 PHE PHE A . n A 1 406 THR 406 406 406 THR THR A . n A 1 407 LYS 407 407 407 LYS LYS A . n A 1 408 LYS 408 408 408 LYS LYS A . n A 1 409 PHE 409 409 409 PHE PHE A . n A 1 410 SER 410 410 410 SER SER A . n A 1 411 GLU 411 411 411 GLU GLU A . n A 1 412 TRP 412 412 412 TRP TRP A . n A 1 413 GLY 413 413 413 GLY GLY A . n A 1 414 ASN 414 414 414 ASN ASN A . n A 1 415 ASN 415 415 415 ASN ASN A . n A 1 416 ALA 416 416 416 ALA ALA A . n A 1 417 PHE 417 417 417 PHE PHE A . n A 1 418 PHE 418 418 418 PHE PHE A . n A 1 419 TYR 419 419 419 TYR TYR A . n A 1 420 TYR 420 420 420 TYR TYR A . n A 1 421 PHE 421 421 421 PHE PHE A . n A 1 422 GLU 422 422 422 GLU GLU A . n A 1 423 HIS 423 423 423 HIS HIS A . n A 1 424 ARG 424 424 424 ARG ARG A . n A 1 425 SER 425 425 425 SER SER A . n A 1 426 SER 426 426 426 SER SER A . n A 1 427 LYS 427 427 427 LYS LYS A . n A 1 428 LEU 428 428 428 LEU LEU A . n A 1 429 PRO 429 429 429 PRO PRO A . n A 1 430 TRP 430 430 430 TRP TRP A . n A 1 431 PRO 431 431 431 PRO PRO A . n A 1 432 GLU 432 432 432 GLU GLU A . n A 1 433 TRP 433 433 433 TRP TRP A . n A 1 434 MET 434 434 434 MET MET A . n A 1 435 GLY 435 435 435 GLY GLY A . n A 1 436 VAL 436 436 436 VAL VAL A . n A 1 437 MET 437 437 437 MET MET A . n A 1 438 HIS 438 438 438 HIS HIS A . n A 1 439 GLY 439 439 439 GLY GLY A . n A 1 440 TYR 440 440 440 TYR TYR A . n A 1 441 GLU 441 441 441 GLU GLU A . n A 1 442 ILE 442 442 442 ILE ILE A . n A 1 443 GLU 443 443 443 GLU GLU A . n A 1 444 PHE 444 444 444 PHE PHE A . n A 1 445 VAL 445 445 445 VAL VAL A . n A 1 446 PHE 446 446 446 PHE PHE A . n A 1 447 GLY 447 447 447 GLY GLY A . n A 1 448 LEU 448 448 448 LEU LEU A . n A 1 449 PRO 449 449 449 PRO PRO A . n A 1 450 LEU 450 450 450 LEU LEU A . n A 1 451 GLU 451 451 451 GLU GLU A . n A 1 452 ARG 452 452 452 ARG ARG A . n A 1 453 ARG 453 453 453 ARG ARG A . n A 1 454 ASP 454 454 454 ASP ASP A . n A 1 455 GLN 455 455 455 GLN GLN A . n A 1 456 TYR 456 456 456 TYR TYR A . n A 1 457 THR 457 457 457 THR THR A . n A 1 458 LYS 458 458 458 LYS LYS A . n A 1 459 ALA 459 459 459 ALA ALA A . n A 1 460 GLU 460 460 460 GLU GLU A . n A 1 461 GLU 461 461 461 GLU GLU A . n A 1 462 ILE 462 462 462 ILE ILE A . n A 1 463 LEU 463 463 463 LEU LEU A . n A 1 464 SER 464 464 464 SER SER A . n A 1 465 ARG 465 465 465 ARG ARG A . n A 1 466 SER 466 466 466 SER SER A . n A 1 467 ILE 467 467 467 ILE ILE A . n A 1 468 VAL 468 468 468 VAL VAL A . n A 1 469 LYS 469 469 469 LYS LYS A . n A 1 470 ARG 470 470 470 ARG ARG A . n A 1 471 TRP 471 471 471 TRP TRP A . n A 1 472 ALA 472 472 472 ALA ALA A . n A 1 473 ASN 473 473 473 ASN ASN A . n A 1 474 PHE 474 474 474 PHE PHE A . n A 1 475 ALA 475 475 475 ALA ALA A . n A 1 476 LYS 476 476 476 LYS LYS A . n A 1 477 TYR 477 477 477 TYR TYR A . n A 1 478 GLY 478 478 478 GLY GLY A . n A 1 479 ASN 479 479 479 ASN ASN A . n A 1 480 PRO 480 480 480 PRO PRO A . n A 1 481 GLN 481 481 481 GLN GLN A . n A 1 482 GLU 482 482 482 GLU GLU A . n A 1 483 THR 483 483 483 THR THR A . n A 1 484 GLN 484 484 484 GLN GLN A . n A 1 485 ASN 485 485 485 ASN ASN A . n A 1 486 GLN 486 486 486 GLN GLN A . n A 1 487 SER 487 487 487 SER SER A . n A 1 488 THR 488 488 488 THR THR A . n A 1 489 SER 489 489 489 SER SER A . n A 1 490 TRP 490 490 490 TRP TRP A . n A 1 491 PRO 491 491 491 PRO PRO A . n A 1 492 VAL 492 492 492 VAL VAL A . n A 1 493 PHE 493 493 493 PHE PHE A . n A 1 494 LYS 494 494 494 LYS LYS A . n A 1 495 SER 495 495 495 SER SER A . n A 1 496 THR 496 496 496 THR THR A . n A 1 497 GLU 497 497 497 GLU GLU A . n A 1 498 GLN 498 498 498 GLN GLN A . n A 1 499 LYS 499 499 499 LYS LYS A . n A 1 500 TYR 500 500 500 TYR TYR A . n A 1 501 LEU 501 501 501 LEU LEU A . n A 1 502 THR 502 502 502 THR THR A . n A 1 503 LEU 503 503 503 LEU LEU A . n A 1 504 ASN 504 504 504 ASN ASN A . n A 1 505 THR 505 505 505 THR THR A . n A 1 506 GLU 506 506 506 GLU GLU A . n A 1 507 SER 507 507 507 SER SER A . n A 1 508 THR 508 508 508 THR THR A . n A 1 509 ARG 509 509 509 ARG ARG A . n A 1 510 ILE 510 510 510 ILE ILE A . n A 1 511 MET 511 511 511 MET MET A . n A 1 512 THR 512 512 512 THR THR A . n A 1 513 LYS 513 513 513 LYS LYS A . n A 1 514 LEU 514 514 514 LEU LEU A . n A 1 515 ARG 515 515 515 ARG ARG A . n A 1 516 ALA 516 516 516 ALA ALA A . n A 1 517 GLN 517 517 517 GLN GLN A . n A 1 518 GLN 518 518 518 GLN GLN A . n A 1 519 CYS 519 519 519 CYS CYS A . n A 1 520 ARG 520 520 520 ARG ARG A . n A 1 521 PHE 521 521 521 PHE PHE A . n A 1 522 TRP 522 522 522 TRP TRP A . n A 1 523 THR 523 523 523 THR THR A . n A 1 524 SER 524 524 524 SER SER A . n A 1 525 PHE 525 525 525 PHE PHE A . n A 1 526 PHE 526 526 526 PHE PHE A . n A 1 527 PRO 527 527 527 PRO PRO A . n A 1 528 LYS 528 528 528 LYS LYS A . n A 1 529 VAL 529 529 529 VAL VAL A . n # loop_ _pdbx_nonpoly_scheme.asym_id _pdbx_nonpoly_scheme.entity_id _pdbx_nonpoly_scheme.mon_id _pdbx_nonpoly_scheme.ndb_seq_num _pdbx_nonpoly_scheme.pdb_seq_num _pdbx_nonpoly_scheme.auth_seq_num _pdbx_nonpoly_scheme.pdb_mon_id _pdbx_nonpoly_scheme.auth_mon_id _pdbx_nonpoly_scheme.pdb_strand_id _pdbx_nonpoly_scheme.pdb_ins_code B 2 NAG 1 530 1 NAG NAG A . C 2 NAG 2 531 2 NAG NAG A . D 3 FUL 3 532 3 FUL FUC A . E 2 NAG 1 533 1 NAG NAG A . F 2 NAG 2 534 2 NAG NAG A . G 2 NAG 1 535 1 NAG NAG A . H 2 NAG 1 536 1 NAG NAG A . I 2 NAG 1 537 1 NAG NAG A . J 2 NAG 1 538 1 NAG NAG A . K 4 SO4 1 601 601 SO4 SO4 A . L 4 SO4 1 602 602 SO4 SO4 A . M 4 SO4 1 603 603 SO4 SO4 A . N 5 CL 1 701 701 CL CL A . O 5 CL 1 702 702 CL CL A . P 5 CL 1 703 703 CL CL A . Q 6 EFS 1 1001 1001 EFS EFS A . R 7 GOL 1 604 604 GOL GOL A . S 7 GOL 1 605 605 GOL GOL A . T 7 GOL 1 606 606 GOL GOL A . U 7 GOL 1 607 607 GOL GOL A . V 8 HOH 1 1102 1 HOH HOH A . V 8 HOH 2 1103 2 HOH HOH A . V 8 HOH 3 1104 3 HOH HOH A . V 8 HOH 4 1105 4 HOH HOH A . V 8 HOH 5 1106 5 HOH HOH A . V 8 HOH 6 1107 6 HOH HOH A . V 8 HOH 7 1108 7 HOH HOH A . V 8 HOH 8 1109 8 HOH HOH A . V 8 HOH 9 1110 9 HOH HOH A . V 8 HOH 10 1111 10 HOH HOH A . V 8 HOH 11 1112 11 HOH HOH A . V 8 HOH 12 1113 12 HOH HOH A . V 8 HOH 13 1114 13 HOH HOH A . V 8 HOH 14 1115 14 HOH HOH A . V 8 HOH 15 1116 15 HOH HOH A . V 8 HOH 16 1117 16 HOH HOH A . V 8 HOH 17 1118 17 HOH HOH A . V 8 HOH 18 1119 18 HOH HOH A . V 8 HOH 19 1120 19 HOH HOH A . V 8 HOH 20 1121 20 HOH HOH A . V 8 HOH 21 1122 21 HOH HOH A . V 8 HOH 22 1123 22 HOH HOH A . V 8 HOH 23 1124 23 HOH HOH A . V 8 HOH 24 1125 24 HOH HOH A . V 8 HOH 25 1126 25 HOH HOH A . V 8 HOH 26 1127 26 HOH HOH A . V 8 HOH 27 1128 27 HOH HOH A . V 8 HOH 28 1129 28 HOH HOH A . V 8 HOH 29 1130 29 HOH HOH A . V 8 HOH 30 1131 30 HOH HOH A . V 8 HOH 31 1132 31 HOH HOH A . V 8 HOH 32 1133 32 HOH HOH A . V 8 HOH 33 1134 33 HOH HOH A . V 8 HOH 34 1135 34 HOH HOH A . V 8 HOH 35 1136 35 HOH HOH A . V 8 HOH 36 1137 36 HOH HOH A . V 8 HOH 37 1138 37 HOH HOH A . V 8 HOH 38 1139 38 HOH HOH A . V 8 HOH 39 1140 39 HOH HOH A . V 8 HOH 40 1141 40 HOH HOH A . V 8 HOH 41 1142 41 HOH HOH A . V 8 HOH 42 1143 42 HOH HOH A . V 8 HOH 43 1144 43 HOH HOH A . V 8 HOH 44 1145 44 HOH HOH A . V 8 HOH 45 1146 45 HOH HOH A . V 8 HOH 46 1147 46 HOH HOH A . V 8 HOH 47 1148 47 HOH HOH A . V 8 HOH 48 1149 48 HOH HOH A . V 8 HOH 49 1150 49 HOH HOH A . V 8 HOH 50 1151 50 HOH HOH A . V 8 HOH 51 1152 51 HOH HOH A . V 8 HOH 52 1153 52 HOH HOH A . V 8 HOH 53 1154 53 HOH HOH A . V 8 HOH 54 1155 54 HOH HOH A . V 8 HOH 55 1156 55 HOH HOH A . V 8 HOH 56 1157 56 HOH HOH A . V 8 HOH 57 1158 57 HOH HOH A . V 8 HOH 58 1159 58 HOH HOH A . V 8 HOH 59 1160 59 HOH HOH A . V 8 HOH 60 1161 60 HOH HOH A . V 8 HOH 61 1162 61 HOH HOH A . V 8 HOH 62 1163 62 HOH HOH A . V 8 HOH 63 1164 63 HOH HOH A . V 8 HOH 64 1165 64 HOH HOH A . V 8 HOH 65 1166 65 HOH HOH A . V 8 HOH 66 1167 66 HOH HOH A . V 8 HOH 67 1168 67 HOH HOH A . V 8 HOH 68 1169 68 HOH HOH A . V 8 HOH 69 1170 69 HOH HOH A . V 8 HOH 70 1171 70 HOH HOH A . V 8 HOH 71 1172 71 HOH HOH A . V 8 HOH 72 1173 72 HOH HOH A . V 8 HOH 73 1174 73 HOH HOH A . V 8 HOH 74 1175 74 HOH HOH A . V 8 HOH 75 1176 75 HOH HOH A . V 8 HOH 76 1177 76 HOH HOH A . V 8 HOH 77 1178 77 HOH HOH A . V 8 HOH 78 1179 78 HOH HOH A . V 8 HOH 79 1180 79 HOH HOH A . V 8 HOH 80 1181 80 HOH HOH A . V 8 HOH 81 1182 81 HOH HOH A . V 8 HOH 82 1183 82 HOH HOH A . V 8 HOH 83 1184 83 HOH HOH A . V 8 HOH 84 1185 84 HOH HOH A . V 8 HOH 85 1186 85 HOH HOH A . V 8 HOH 86 1187 86 HOH HOH A . V 8 HOH 87 1188 87 HOH HOH A . V 8 HOH 88 1189 88 HOH HOH A . V 8 HOH 89 1190 89 HOH HOH A . V 8 HOH 90 1191 90 HOH HOH A . V 8 HOH 91 1192 91 HOH HOH A . V 8 HOH 92 1193 92 HOH HOH A . V 8 HOH 93 1194 93 HOH HOH A . V 8 HOH 94 1195 94 HOH HOH A . V 8 HOH 95 1196 95 HOH HOH A . V 8 HOH 96 1197 96 HOH HOH A . V 8 HOH 97 1198 97 HOH HOH A . V 8 HOH 98 1199 98 HOH HOH A . V 8 HOH 99 1200 99 HOH HOH A . V 8 HOH 100 1201 100 HOH HOH A . V 8 HOH 101 1202 101 HOH HOH A . V 8 HOH 102 1203 102 HOH HOH A . V 8 HOH 103 1204 103 HOH HOH A . V 8 HOH 104 1205 104 HOH HOH A . V 8 HOH 105 1206 105 HOH HOH A . V 8 HOH 106 1207 106 HOH HOH A . V 8 HOH 107 1208 107 HOH HOH A . V 8 HOH 108 1209 108 HOH HOH A . V 8 HOH 109 1210 109 HOH HOH A . V 8 HOH 110 1211 110 HOH HOH A . V 8 HOH 111 1212 111 HOH HOH A . V 8 HOH 112 1213 112 HOH HOH A . V 8 HOH 113 1214 113 HOH HOH A . V 8 HOH 114 1215 114 HOH HOH A . V 8 HOH 115 1216 115 HOH HOH A . V 8 HOH 116 1217 116 HOH HOH A . V 8 HOH 117 1218 117 HOH HOH A . V 8 HOH 118 1219 118 HOH HOH A . V 8 HOH 119 1220 119 HOH HOH A . V 8 HOH 120 1221 120 HOH HOH A . V 8 HOH 121 1222 121 HOH HOH A . V 8 HOH 122 1223 122 HOH HOH A . V 8 HOH 123 1224 123 HOH HOH A . V 8 HOH 124 1225 124 HOH HOH A . V 8 HOH 125 1226 125 HOH HOH A . V 8 HOH 126 1227 126 HOH HOH A . V 8 HOH 127 1228 127 HOH HOH A . V 8 HOH 128 1229 128 HOH HOH A . V 8 HOH 129 1230 129 HOH HOH A . V 8 HOH 130 1231 130 HOH HOH A . V 8 HOH 131 1232 131 HOH HOH A . V 8 HOH 132 1233 132 HOH HOH A . V 8 HOH 133 1234 133 HOH HOH A . V 8 HOH 134 1235 134 HOH HOH A . V 8 HOH 135 1236 135 HOH HOH A . V 8 HOH 136 1237 136 HOH HOH A . V 8 HOH 137 1238 137 HOH HOH A . V 8 HOH 138 1239 138 HOH HOH A . V 8 HOH 139 1240 139 HOH HOH A . V 8 HOH 140 1241 140 HOH HOH A . V 8 HOH 141 1242 141 HOH HOH A . V 8 HOH 142 1243 142 HOH HOH A . V 8 HOH 143 1244 143 HOH HOH A . V 8 HOH 144 1245 144 HOH HOH A . V 8 HOH 145 1246 145 HOH HOH A . V 8 HOH 146 1247 146 HOH HOH A . V 8 HOH 147 1248 147 HOH HOH A . V 8 HOH 148 1249 148 HOH HOH A . V 8 HOH 149 1250 149 HOH HOH A . V 8 HOH 150 1251 150 HOH HOH A . V 8 HOH 151 1252 151 HOH HOH A . V 8 HOH 152 1253 152 HOH HOH A . V 8 HOH 153 1254 153 HOH HOH A . V 8 HOH 154 1255 154 HOH HOH A . V 8 HOH 155 1256 155 HOH HOH A . V 8 HOH 156 1257 156 HOH HOH A . V 8 HOH 157 1258 157 HOH HOH A . V 8 HOH 158 1259 158 HOH HOH A . V 8 HOH 159 1260 159 HOH HOH A . V 8 HOH 160 1261 160 HOH HOH A . V 8 HOH 161 1262 161 HOH HOH A . V 8 HOH 162 1263 162 HOH HOH A . V 8 HOH 163 1264 163 HOH HOH A . V 8 HOH 164 1265 164 HOH HOH A . V 8 HOH 165 1266 165 HOH HOH A . V 8 HOH 166 1267 166 HOH HOH A . V 8 HOH 167 1268 167 HOH HOH A . V 8 HOH 168 1269 168 HOH HOH A . V 8 HOH 169 1270 169 HOH HOH A . V 8 HOH 170 1271 170 HOH HOH A . V 8 HOH 171 1272 171 HOH HOH A . V 8 HOH 172 1273 172 HOH HOH A . V 8 HOH 173 1274 173 HOH HOH A . V 8 HOH 174 1275 174 HOH HOH A . V 8 HOH 175 1276 175 HOH HOH A . V 8 HOH 176 1277 176 HOH HOH A . V 8 HOH 177 1278 177 HOH HOH A . V 8 HOH 178 1279 178 HOH HOH A . V 8 HOH 179 1280 179 HOH HOH A . V 8 HOH 180 1281 180 HOH HOH A . V 8 HOH 181 1282 181 HOH HOH A . V 8 HOH 182 1283 182 HOH HOH A . V 8 HOH 183 1284 183 HOH HOH A . V 8 HOH 184 1285 184 HOH HOH A . V 8 HOH 185 1286 185 HOH HOH A . V 8 HOH 186 1287 186 HOH HOH A . V 8 HOH 187 1288 187 HOH HOH A . V 8 HOH 188 1289 188 HOH HOH A . V 8 HOH 189 1290 189 HOH HOH A . V 8 HOH 190 1291 190 HOH HOH A . V 8 HOH 191 1292 191 HOH HOH A . V 8 HOH 192 1293 192 HOH HOH A . V 8 HOH 193 1294 193 HOH HOH A . V 8 HOH 194 1295 194 HOH HOH A . V 8 HOH 195 1296 195 HOH HOH A . V 8 HOH 196 1297 196 HOH HOH A . V 8 HOH 197 1298 197 HOH HOH A . V 8 HOH 198 1299 198 HOH HOH A . V 8 HOH 199 1300 199 HOH HOH A . V 8 HOH 200 1301 200 HOH HOH A . V 8 HOH 201 1302 201 HOH HOH A . V 8 HOH 202 1303 202 HOH HOH A . V 8 HOH 203 1304 203 HOH HOH A . V 8 HOH 204 1305 204 HOH HOH A . V 8 HOH 205 1306 205 HOH HOH A . V 8 HOH 206 1307 206 HOH HOH A . V 8 HOH 207 1308 207 HOH HOH A . V 8 HOH 208 1309 208 HOH HOH A . V 8 HOH 209 1310 209 HOH HOH A . V 8 HOH 210 1311 210 HOH HOH A . V 8 HOH 211 1312 211 HOH HOH A . V 8 HOH 212 1313 212 HOH HOH A . V 8 HOH 213 1314 213 HOH HOH A . V 8 HOH 214 1315 214 HOH HOH A . V 8 HOH 215 1316 215 HOH HOH A . V 8 HOH 216 1317 216 HOH HOH A . V 8 HOH 217 1318 217 HOH HOH A . V 8 HOH 218 1319 218 HOH HOH A . V 8 HOH 219 1320 219 HOH HOH A . V 8 HOH 220 1321 220 HOH HOH A . # loop_ _pdbx_struct_mod_residue.id _pdbx_struct_mod_residue.label_asym_id _pdbx_struct_mod_residue.label_comp_id _pdbx_struct_mod_residue.label_seq_id _pdbx_struct_mod_residue.auth_asym_id _pdbx_struct_mod_residue.auth_comp_id _pdbx_struct_mod_residue.auth_seq_id _pdbx_struct_mod_residue.PDB_ins_code _pdbx_struct_mod_residue.parent_comp_id _pdbx_struct_mod_residue.details 1 A ASN 57 A ASN 57 ? ASN 'GLYCOSYLATION SITE' 2 A ASN 106 A ASN 106 ? ASN 'GLYCOSYLATION SITE' 3 A ASN 241 A ASN 241 ? ASN 'GLYCOSYLATION SITE' 4 A ASN 256 A ASN 256 ? ASN 'GLYCOSYLATION SITE' 5 A ASN 341 A ASN 341 ? ASN 'GLYCOSYLATION SITE' 6 A ASN 485 A ASN 485 ? ASN 'GLYCOSYLATION SITE' 7 A CSS 66 A CSS 66 ? CYS S-MERCAPTOCYSTEINE # loop_ _pdbx_struct_assembly.id _pdbx_struct_assembly.details _pdbx_struct_assembly.method_details _pdbx_struct_assembly.oligomeric_details _pdbx_struct_assembly.oligomeric_count 1 software_defined_assembly PISA dimeric 2 2 author_defined_assembly ? monomeric 1 # loop_ _pdbx_struct_assembly_gen.assembly_id _pdbx_struct_assembly_gen.oper_expression _pdbx_struct_assembly_gen.asym_id_list 1 1,2 A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R,S,T,U,V 2 1 A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R,S,T,U,V # loop_ _pdbx_struct_assembly_prop.biol_id _pdbx_struct_assembly_prop.type _pdbx_struct_assembly_prop.value _pdbx_struct_assembly_prop.details 1 'ABSA (A^2)' 10200 ? 1 MORE -78 ? 1 'SSA (A^2)' 41550 ? # loop_ _pdbx_struct_oper_list.id _pdbx_struct_oper_list.type _pdbx_struct_oper_list.name _pdbx_struct_oper_list.symmetry_operation _pdbx_struct_oper_list.matrix[1][1] _pdbx_struct_oper_list.matrix[1][2] _pdbx_struct_oper_list.matrix[1][3] _pdbx_struct_oper_list.vector[1] _pdbx_struct_oper_list.matrix[2][1] _pdbx_struct_oper_list.matrix[2][2] _pdbx_struct_oper_list.matrix[2][3] _pdbx_struct_oper_list.vector[2] _pdbx_struct_oper_list.matrix[3][1] _pdbx_struct_oper_list.matrix[3][2] _pdbx_struct_oper_list.matrix[3][3] _pdbx_struct_oper_list.vector[3] 1 'identity operation' 1_555 x,y,z 1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 2 'crystal symmetry operation' 6_556 x,-y,-z+1 1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 126.7060000000 # _pdbx_struct_special_symmetry.id 1 _pdbx_struct_special_symmetry.PDB_model_num 1 _pdbx_struct_special_symmetry.auth_asym_id A _pdbx_struct_special_symmetry.auth_comp_id HOH _pdbx_struct_special_symmetry.auth_seq_id 1315 _pdbx_struct_special_symmetry.PDB_ins_code ? _pdbx_struct_special_symmetry.label_asym_id V _pdbx_struct_special_symmetry.label_comp_id HOH _pdbx_struct_special_symmetry.label_seq_id . # loop_ _pdbx_audit_revision_history.ordinal _pdbx_audit_revision_history.data_content_type _pdbx_audit_revision_history.major_revision _pdbx_audit_revision_history.minor_revision _pdbx_audit_revision_history.revision_date 1 'Structure model' 1 0 2005-02-01 2 'Structure model' 1 1 2008-04-30 3 'Structure model' 1 2 2011-07-13 4 'Structure model' 1 3 2017-10-11 # _pdbx_audit_revision_details.ordinal 1 _pdbx_audit_revision_details.revision_ordinal 1 _pdbx_audit_revision_details.data_content_type 'Structure model' _pdbx_audit_revision_details.provider repository _pdbx_audit_revision_details.type 'Initial release' _pdbx_audit_revision_details.description ? # loop_ _pdbx_audit_revision_group.ordinal _pdbx_audit_revision_group.revision_ordinal _pdbx_audit_revision_group.data_content_type _pdbx_audit_revision_group.group 1 2 'Structure model' 'Version format compliance' 2 3 'Structure model' 'Non-polymer description' 3 3 'Structure model' 'Version format compliance' 4 4 'Structure model' 'Refinement description' # _pdbx_audit_revision_category.ordinal 1 _pdbx_audit_revision_category.revision_ordinal 4 _pdbx_audit_revision_category.data_content_type 'Structure model' _pdbx_audit_revision_category.category software # loop_ _software.name _software.classification _software.version _software.citation_id _software.pdbx_ordinal SCALEPACK 'data scaling' . ? 1 AMoRE phasing . ? 2 REFMAC refinement 5.2 ? 3 # _pdbx_validate_close_contact.id 1 _pdbx_validate_close_contact.PDB_model_num 1 _pdbx_validate_close_contact.auth_atom_id_1 O _pdbx_validate_close_contact.auth_asym_id_1 A _pdbx_validate_close_contact.auth_comp_id_1 HOH _pdbx_validate_close_contact.auth_seq_id_1 1145 _pdbx_validate_close_contact.PDB_ins_code_1 ? _pdbx_validate_close_contact.label_alt_id_1 ? _pdbx_validate_close_contact.auth_atom_id_2 O _pdbx_validate_close_contact.auth_asym_id_2 A _pdbx_validate_close_contact.auth_comp_id_2 HOH _pdbx_validate_close_contact.auth_seq_id_2 1192 _pdbx_validate_close_contact.PDB_ins_code_2 ? _pdbx_validate_close_contact.label_alt_id_2 ? _pdbx_validate_close_contact.dist 2.14 # loop_ _pdbx_validate_rmsd_angle.id _pdbx_validate_rmsd_angle.PDB_model_num _pdbx_validate_rmsd_angle.auth_atom_id_1 _pdbx_validate_rmsd_angle.auth_asym_id_1 _pdbx_validate_rmsd_angle.auth_comp_id_1 _pdbx_validate_rmsd_angle.auth_seq_id_1 _pdbx_validate_rmsd_angle.PDB_ins_code_1 _pdbx_validate_rmsd_angle.label_alt_id_1 _pdbx_validate_rmsd_angle.auth_atom_id_2 _pdbx_validate_rmsd_angle.auth_asym_id_2 _pdbx_validate_rmsd_angle.auth_comp_id_2 _pdbx_validate_rmsd_angle.auth_seq_id_2 _pdbx_validate_rmsd_angle.PDB_ins_code_2 _pdbx_validate_rmsd_angle.label_alt_id_2 _pdbx_validate_rmsd_angle.auth_atom_id_3 _pdbx_validate_rmsd_angle.auth_asym_id_3 _pdbx_validate_rmsd_angle.auth_comp_id_3 _pdbx_validate_rmsd_angle.auth_seq_id_3 _pdbx_validate_rmsd_angle.PDB_ins_code_3 _pdbx_validate_rmsd_angle.label_alt_id_3 _pdbx_validate_rmsd_angle.angle_value _pdbx_validate_rmsd_angle.angle_target_value _pdbx_validate_rmsd_angle.angle_deviation _pdbx_validate_rmsd_angle.angle_standard_deviation _pdbx_validate_rmsd_angle.linker_flag 1 1 CB A ASP 70 ? ? CG A ASP 70 ? ? OD2 A ASP 70 ? ? 124.84 118.30 6.54 0.90 N 2 1 CB A ASP 87 ? A CG A ASP 87 ? A OD2 A ASP 87 ? A 124.16 118.30 5.86 0.90 N 3 1 CB A ASP 268 ? ? CG A ASP 268 ? ? OD2 A ASP 268 ? ? 124.15 118.30 5.85 0.90 N 4 1 CB A ASP 295 ? ? CG A ASP 295 ? ? OD2 A ASP 295 ? ? 124.31 118.30 6.01 0.90 N 5 1 CB A ASP 301 ? ? CG A ASP 301 ? ? OD2 A ASP 301 ? ? 124.32 118.30 6.02 0.90 N 6 1 CB A ASP 395 ? ? CG A ASP 395 ? ? OD2 A ASP 395 ? ? 124.54 118.30 6.24 0.90 N 7 1 NE A ARG 465 ? ? CZ A ARG 465 ? ? NH1 A ARG 465 ? ? 123.34 120.30 3.04 0.50 N 8 1 NE A ARG 465 ? ? CZ A ARG 465 ? ? NH2 A ARG 465 ? ? 116.87 120.30 -3.43 0.50 N # loop_ _pdbx_validate_torsion.id _pdbx_validate_torsion.PDB_model_num _pdbx_validate_torsion.auth_comp_id _pdbx_validate_torsion.auth_asym_id _pdbx_validate_torsion.auth_seq_id _pdbx_validate_torsion.PDB_ins_code _pdbx_validate_torsion.label_alt_id _pdbx_validate_torsion.phi _pdbx_validate_torsion.psi 1 1 PHE A 43 ? ? 80.85 -5.98 2 1 ASP A 54 ? ? 58.60 172.95 3 1 ALA A 58 ? ? -101.12 67.04 4 1 GLN A 67 ? ? -170.20 148.95 5 1 ASN A 106 ? ? -154.97 57.78 6 1 ALA A 162 ? ? -155.37 70.40 7 1 SER A 198 ? ? 50.20 -120.34 8 1 ARG A 254 ? ? -138.91 -141.60 9 1 GLU A 255 ? ? -158.62 -37.95 10 1 PRO A 285 ? ? -59.84 -9.82 11 1 ASP A 297 ? ? -127.36 -71.76 12 1 SER A 362 ? ? -46.65 155.92 13 1 SER A 362 ? ? -46.65 153.85 14 1 PHE A 398 ? ? -126.08 -50.38 15 1 GLN A 455 ? ? 81.26 6.86 # loop_ _pdbx_unobs_or_zero_occ_residues.id _pdbx_unobs_or_zero_occ_residues.PDB_model_num _pdbx_unobs_or_zero_occ_residues.polymer_flag _pdbx_unobs_or_zero_occ_residues.occupancy_flag _pdbx_unobs_or_zero_occ_residues.auth_asym_id _pdbx_unobs_or_zero_occ_residues.auth_comp_id _pdbx_unobs_or_zero_occ_residues.auth_seq_id _pdbx_unobs_or_zero_occ_residues.PDB_ins_code _pdbx_unobs_or_zero_occ_residues.label_asym_id _pdbx_unobs_or_zero_occ_residues.label_comp_id _pdbx_unobs_or_zero_occ_residues.label_seq_id 1 1 Y 1 A GLU 1 ? A GLU 1 2 1 Y 1 A ASP 2 ? A ASP 2 3 1 Y 1 A ASP 3 ? A ASP 3 4 1 Y 1 A ASP 378 ? A ASP 378 5 1 Y 1 A ASP 379 ? A ASP 379 # loop_ _pdbx_entity_nonpoly.entity_id _pdbx_entity_nonpoly.name _pdbx_entity_nonpoly.comp_id 2 N-ACETYL-D-GLUCOSAMINE NAG 3 BETA-L-FUCOSE FUL 4 'SULFATE ION' SO4 5 'CHLORIDE ION' CL 6 'ETHYL DIHYDROGEN PHOSPHATE' EFS 7 GLYCEROL GOL 8 water HOH #