data_1W9B # _entry.id 1W9B # _audit_conform.dict_name mmcif_pdbx.dic _audit_conform.dict_version 5.279 _audit_conform.dict_location http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic # loop_ _database_2.database_id _database_2.database_code PDB 1W9B PDBE EBI-21269 WWPDB D_1290021269 # loop_ _pdbx_database_related.db_name _pdbx_database_related.db_id _pdbx_database_related.content_type _pdbx_database_related.details PDB 1MYR unspecified 'MYROSINASE FROM SINAPIS ALBA' PDB 1W9D unspecified 'S. ALBA MYROSINASE IN COMPLEX WITH S-ETHYL PHENYLACETOTHIOHYDROXIMATE-O-SULFATE' # _pdbx_database_status.status_code REL _pdbx_database_status.entry_id 1W9B _pdbx_database_status.deposit_site PDBE _pdbx_database_status.process_site PDBE _pdbx_database_status.SG_entry . _pdbx_database_status.recvd_initial_deposition_date 2004-10-08 _pdbx_database_status.pdb_format_compatible Y _pdbx_database_status.status_code_sf ? _pdbx_database_status.status_code_mr ? _pdbx_database_status.status_code_cs ? _pdbx_database_status.methods_development_category ? # loop_ _audit_author.name _audit_author.pdbx_ordinal 'Bourderioux, A.' 1 'Lefoix, M.' 2 'Gueyrard, D.' 3 'Tatibouet, A.' 4 'Cottaz, S.' 5 'Arzt, S.' 6 'Burmeister, W.P.' 7 'Rollin, P.' 8 # loop_ _citation.id _citation.title _citation.journal_abbrev _citation.journal_volume _citation.page_first _citation.page_last _citation.year _citation.journal_id_ASTM _citation.country _citation.journal_id_ISSN _citation.journal_id_CSD _citation.book_publisher _citation.pdbx_database_id_PubMed _citation.pdbx_database_id_DOI primary 'The Glucosinolate-Myrosinase System. New Insights Into Enzyme-Substrate Interactions by Use of Simplified Inhibitors' Org.Biomol.Chem. 3 1872 ? 2005 ? UK 1477-0520 ? ? 15889170 10.1039/B502990B 1 ;High Resolution X-Ray Crystallography Shows that Ascorbate is a Cofactor for Myrosinase and Substitutes for the Function of the Catalytic Base ; J.Biol.Chem. 275 39385 ? 2000 JBCHA3 US 0021-9258 0071 ? 10978344 10.1074/JBC.M006796200 # loop_ _citation_author.citation_id _citation_author.name _citation_author.ordinal primary 'Bourderioux, A.' 1 primary 'Lefoix, M.' 2 primary 'Gueyrard, D.' 3 primary 'Tatibouet, A.' 4 primary 'Cottaz, S.' 5 primary 'Arzt, S.' 6 primary 'Burmeister, W.P.' 7 primary 'Rollin, P.' 8 1 'Burmeister, W.P.' 9 1 'Cottaz, S.' 10 1 'Rollin, P.' 11 1 'Vasella, A.' 12 1 'Henrissat, B.' 13 # _cell.entry_id 1W9B _cell.length_a 135.300 _cell.length_b 137.200 _cell.length_c 80.600 _cell.angle_alpha 90.00 _cell.angle_beta 90.00 _cell.angle_gamma 90.00 _cell.Z_PDB 8 _cell.pdbx_unique_axis ? # _symmetry.entry_id 1W9B _symmetry.space_group_name_H-M 'C 2 2 21' _symmetry.pdbx_full_space_group_name_H-M ? _symmetry.cell_setting ? _symmetry.Int_Tables_number 20 # loop_ _entity.id _entity.type _entity.src_method _entity.pdbx_description _entity.formula_weight _entity.pdbx_number_of_molecules _entity.pdbx_ec _entity.pdbx_mutation _entity.pdbx_fragment _entity.details 1 polymer nat GLYCOSIDASE 57078.289 1 3.2.3.1 ? ? ? 2 non-polymer man N-ACETYL-D-GLUCOSAMINE 221.208 14 ? ? ? ? 3 non-polymer man ALPHA-L-FUCOSE 164.156 2 ? ? ? ? 4 non-polymer man BETA-D-MANNOSE 180.156 2 ? ? ? ? 5 non-polymer man BETA-D-XYLOPYRANOSE 150.130 2 ? ? ? ? 6 non-polymer man ALPHA-D-MANNOSE 180.156 2 ? ? ? ? 7 non-polymer syn CARBA-GLUCOTROPAEOLIN 407.459 1 ? ? ? ? 8 non-polymer syn GLYCEROL 92.094 3 ? ? ? ? 9 non-polymer syn 'ZINC ION' 65.409 1 ? ? ? ? 10 non-polymer syn 'SULFATE ION' 96.063 4 ? ? ? ? 11 water nat water 18.015 764 ? ? ? ? # _entity_name_com.entity_id 1 _entity_name_com.name MYROSINASE # _entity_poly.entity_id 1 _entity_poly.type 'polypeptide(L)' _entity_poly.nstd_linkage no _entity_poly.nstd_monomer no _entity_poly.pdbx_seq_one_letter_code ;DEEITCQENLPFTCGNTDALNSSSFSSDFIFGVASSAYQIEGTIGRGLNIWDGFTHRYPNKSGPDHGNGDTTCDSFSYWQ KDIDVLDELNATGYRFSIAWSRIIPRGKRSRGVNEKGIDYYHGLISGLIKKGITPFVTLFHWDLPQTLQDEYEGFLDPQI IDDFKDYADLCFEEFGDSVKYWLTINQLYSVPTRGYGSALDAPGRCSPTVDPSCYAGNSSTEPYIVAHHQLLAHAKVVDL YRKNYTHQGGKIGPTMITRWFLPYNDTDRHSIAATERMKEFFLGWFMGPLTNGTYPQIMIDTVGERLPSFSPEESNLVKG SYDFLGLNYYFTQYAQPSPNPVNSTNHTAMMDAGAKLTYINASGHYIGPLFEKDKADSTDNIYYYPKGIYSVMDYFKNKY YNPLIYVTENGISTPGDENRNQSMLDYTRIDYLCSHLCFLNKVIKEKDVNVKGYLAWALGDNYEFNKGFTVRFGLSYIDW NNVTDRDLKKSGQWYQSFISP ; _entity_poly.pdbx_seq_one_letter_code_can ;DEEITCQENLPFTCGNTDALNSSSFSSDFIFGVASSAYQIEGTIGRGLNIWDGFTHRYPNKSGPDHGNGDTTCDSFSYWQ KDIDVLDELNATGYRFSIAWSRIIPRGKRSRGVNEKGIDYYHGLISGLIKKGITPFVTLFHWDLPQTLQDEYEGFLDPQI IDDFKDYADLCFEEFGDSVKYWLTINQLYSVPTRGYGSALDAPGRCSPTVDPSCYAGNSSTEPYIVAHHQLLAHAKVVDL YRKNYTHQGGKIGPTMITRWFLPYNDTDRHSIAATERMKEFFLGWFMGPLTNGTYPQIMIDTVGERLPSFSPEESNLVKG SYDFLGLNYYFTQYAQPSPNPVNSTNHTAMMDAGAKLTYINASGHYIGPLFEKDKADSTDNIYYYPKGIYSVMDYFKNKY YNPLIYVTENGISTPGDENRNQSMLDYTRIDYLCSHLCFLNKVIKEKDVNVKGYLAWALGDNYEFNKGFTVRFGLSYIDW NNVTDRDLKKSGQWYQSFISP ; _entity_poly.pdbx_strand_id M _entity_poly.pdbx_target_identifier ? # loop_ _entity_poly_seq.entity_id _entity_poly_seq.num _entity_poly_seq.mon_id _entity_poly_seq.hetero 1 1 ASP n 1 2 GLU n 1 3 GLU n 1 4 ILE n 1 5 THR n 1 6 CYS n 1 7 GLN n 1 8 GLU n 1 9 ASN n 1 10 LEU n 1 11 PRO n 1 12 PHE n 1 13 THR n 1 14 CYS n 1 15 GLY n 1 16 ASN n 1 17 THR n 1 18 ASP n 1 19 ALA n 1 20 LEU n 1 21 ASN n 1 22 SER n 1 23 SER n 1 24 SER n 1 25 PHE n 1 26 SER n 1 27 SER n 1 28 ASP n 1 29 PHE n 1 30 ILE n 1 31 PHE n 1 32 GLY n 1 33 VAL n 1 34 ALA n 1 35 SER n 1 36 SER n 1 37 ALA n 1 38 TYR n 1 39 GLN n 1 40 ILE n 1 41 GLU n 1 42 GLY n 1 43 THR n 1 44 ILE n 1 45 GLY n 1 46 ARG n 1 47 GLY n 1 48 LEU n 1 49 ASN n 1 50 ILE n 1 51 TRP n 1 52 ASP n 1 53 GLY n 1 54 PHE n 1 55 THR n 1 56 HIS n 1 57 ARG n 1 58 TYR n 1 59 PRO n 1 60 ASN n 1 61 LYS n 1 62 SER n 1 63 GLY n 1 64 PRO n 1 65 ASP n 1 66 HIS n 1 67 GLY n 1 68 ASN n 1 69 GLY n 1 70 ASP n 1 71 THR n 1 72 THR n 1 73 CYS n 1 74 ASP n 1 75 SER n 1 76 PHE n 1 77 SER n 1 78 TYR n 1 79 TRP n 1 80 GLN n 1 81 LYS n 1 82 ASP n 1 83 ILE n 1 84 ASP n 1 85 VAL n 1 86 LEU n 1 87 ASP n 1 88 GLU n 1 89 LEU n 1 90 ASN n 1 91 ALA n 1 92 THR n 1 93 GLY n 1 94 TYR n 1 95 ARG n 1 96 PHE n 1 97 SER n 1 98 ILE n 1 99 ALA n 1 100 TRP n 1 101 SER n 1 102 ARG n 1 103 ILE n 1 104 ILE n 1 105 PRO n 1 106 ARG n 1 107 GLY n 1 108 LYS n 1 109 ARG n 1 110 SER n 1 111 ARG n 1 112 GLY n 1 113 VAL n 1 114 ASN n 1 115 GLU n 1 116 LYS n 1 117 GLY n 1 118 ILE n 1 119 ASP n 1 120 TYR n 1 121 TYR n 1 122 HIS n 1 123 GLY n 1 124 LEU n 1 125 ILE n 1 126 SER n 1 127 GLY n 1 128 LEU n 1 129 ILE n 1 130 LYS n 1 131 LYS n 1 132 GLY n 1 133 ILE n 1 134 THR n 1 135 PRO n 1 136 PHE n 1 137 VAL n 1 138 THR n 1 139 LEU n 1 140 PHE n 1 141 HIS n 1 142 TRP n 1 143 ASP n 1 144 LEU n 1 145 PRO n 1 146 GLN n 1 147 THR n 1 148 LEU n 1 149 GLN n 1 150 ASP n 1 151 GLU n 1 152 TYR n 1 153 GLU n 1 154 GLY n 1 155 PHE n 1 156 LEU n 1 157 ASP n 1 158 PRO n 1 159 GLN n 1 160 ILE n 1 161 ILE n 1 162 ASP n 1 163 ASP n 1 164 PHE n 1 165 LYS n 1 166 ASP n 1 167 TYR n 1 168 ALA n 1 169 ASP n 1 170 LEU n 1 171 CYS n 1 172 PHE n 1 173 GLU n 1 174 GLU n 1 175 PHE n 1 176 GLY n 1 177 ASP n 1 178 SER n 1 179 VAL n 1 180 LYS n 1 181 TYR n 1 182 TRP n 1 183 LEU n 1 184 THR n 1 185 ILE n 1 186 ASN n 1 187 GLN n 1 188 LEU n 1 189 TYR n 1 190 SER n 1 191 VAL n 1 192 PRO n 1 193 THR n 1 194 ARG n 1 195 GLY n 1 196 TYR n 1 197 GLY n 1 198 SER n 1 199 ALA n 1 200 LEU n 1 201 ASP n 1 202 ALA n 1 203 PRO n 1 204 GLY n 1 205 ARG n 1 206 CYS n 1 207 SER n 1 208 PRO n 1 209 THR n 1 210 VAL n 1 211 ASP n 1 212 PRO n 1 213 SER n 1 214 CYS n 1 215 TYR n 1 216 ALA n 1 217 GLY n 1 218 ASN n 1 219 SER n 1 220 SER n 1 221 THR n 1 222 GLU n 1 223 PRO n 1 224 TYR n 1 225 ILE n 1 226 VAL n 1 227 ALA n 1 228 HIS n 1 229 HIS n 1 230 GLN n 1 231 LEU n 1 232 LEU n 1 233 ALA n 1 234 HIS n 1 235 ALA n 1 236 LYS n 1 237 VAL n 1 238 VAL n 1 239 ASP n 1 240 LEU n 1 241 TYR n 1 242 ARG n 1 243 LYS n 1 244 ASN n 1 245 TYR n 1 246 THR n 1 247 HIS n 1 248 GLN n 1 249 GLY n 1 250 GLY n 1 251 LYS n 1 252 ILE n 1 253 GLY n 1 254 PRO n 1 255 THR n 1 256 MET n 1 257 ILE n 1 258 THR n 1 259 ARG n 1 260 TRP n 1 261 PHE n 1 262 LEU n 1 263 PRO n 1 264 TYR n 1 265 ASN n 1 266 ASP n 1 267 THR n 1 268 ASP n 1 269 ARG n 1 270 HIS n 1 271 SER n 1 272 ILE n 1 273 ALA n 1 274 ALA n 1 275 THR n 1 276 GLU n 1 277 ARG n 1 278 MET n 1 279 LYS n 1 280 GLU n 1 281 PHE n 1 282 PHE n 1 283 LEU n 1 284 GLY n 1 285 TRP n 1 286 PHE n 1 287 MET n 1 288 GLY n 1 289 PRO n 1 290 LEU n 1 291 THR n 1 292 ASN n 1 293 GLY n 1 294 THR n 1 295 TYR n 1 296 PRO n 1 297 GLN n 1 298 ILE n 1 299 MET n 1 300 ILE n 1 301 ASP n 1 302 THR n 1 303 VAL n 1 304 GLY n 1 305 GLU n 1 306 ARG n 1 307 LEU n 1 308 PRO n 1 309 SER n 1 310 PHE n 1 311 SER n 1 312 PRO n 1 313 GLU n 1 314 GLU n 1 315 SER n 1 316 ASN n 1 317 LEU n 1 318 VAL n 1 319 LYS n 1 320 GLY n 1 321 SER n 1 322 TYR n 1 323 ASP n 1 324 PHE n 1 325 LEU n 1 326 GLY n 1 327 LEU n 1 328 ASN n 1 329 TYR n 1 330 TYR n 1 331 PHE n 1 332 THR n 1 333 GLN n 1 334 TYR n 1 335 ALA n 1 336 GLN n 1 337 PRO n 1 338 SER n 1 339 PRO n 1 340 ASN n 1 341 PRO n 1 342 VAL n 1 343 ASN n 1 344 SER n 1 345 THR n 1 346 ASN n 1 347 HIS n 1 348 THR n 1 349 ALA n 1 350 MET n 1 351 MET n 1 352 ASP n 1 353 ALA n 1 354 GLY n 1 355 ALA n 1 356 LYS n 1 357 LEU n 1 358 THR n 1 359 TYR n 1 360 ILE n 1 361 ASN n 1 362 ALA n 1 363 SER n 1 364 GLY n 1 365 HIS n 1 366 TYR n 1 367 ILE n 1 368 GLY n 1 369 PRO n 1 370 LEU n 1 371 PHE n 1 372 GLU n 1 373 LYS n 1 374 ASP n 1 375 LYS n 1 376 ALA n 1 377 ASP n 1 378 SER n 1 379 THR n 1 380 ASP n 1 381 ASN n 1 382 ILE n 1 383 TYR n 1 384 TYR n 1 385 TYR n 1 386 PRO n 1 387 LYS n 1 388 GLY n 1 389 ILE n 1 390 TYR n 1 391 SER n 1 392 VAL n 1 393 MET n 1 394 ASP n 1 395 TYR n 1 396 PHE n 1 397 LYS n 1 398 ASN n 1 399 LYS n 1 400 TYR n 1 401 TYR n 1 402 ASN n 1 403 PRO n 1 404 LEU n 1 405 ILE n 1 406 TYR n 1 407 VAL n 1 408 THR n 1 409 GLU n 1 410 ASN n 1 411 GLY n 1 412 ILE n 1 413 SER n 1 414 THR n 1 415 PRO n 1 416 GLY n 1 417 ASP n 1 418 GLU n 1 419 ASN n 1 420 ARG n 1 421 ASN n 1 422 GLN n 1 423 SER n 1 424 MET n 1 425 LEU n 1 426 ASP n 1 427 TYR n 1 428 THR n 1 429 ARG n 1 430 ILE n 1 431 ASP n 1 432 TYR n 1 433 LEU n 1 434 CYS n 1 435 SER n 1 436 HIS n 1 437 LEU n 1 438 CYS n 1 439 PHE n 1 440 LEU n 1 441 ASN n 1 442 LYS n 1 443 VAL n 1 444 ILE n 1 445 LYS n 1 446 GLU n 1 447 LYS n 1 448 ASP n 1 449 VAL n 1 450 ASN n 1 451 VAL n 1 452 LYS n 1 453 GLY n 1 454 TYR n 1 455 LEU n 1 456 ALA n 1 457 TRP n 1 458 ALA n 1 459 LEU n 1 460 GLY n 1 461 ASP n 1 462 ASN n 1 463 TYR n 1 464 GLU n 1 465 PHE n 1 466 ASN n 1 467 LYS n 1 468 GLY n 1 469 PHE n 1 470 THR n 1 471 VAL n 1 472 ARG n 1 473 PHE n 1 474 GLY n 1 475 LEU n 1 476 SER n 1 477 TYR n 1 478 ILE n 1 479 ASP n 1 480 TRP n 1 481 ASN n 1 482 ASN n 1 483 VAL n 1 484 THR n 1 485 ASP n 1 486 ARG n 1 487 ASP n 1 488 LEU n 1 489 LYS n 1 490 LYS n 1 491 SER n 1 492 GLY n 1 493 GLN n 1 494 TRP n 1 495 TYR n 1 496 GLN n 1 497 SER n 1 498 PHE n 1 499 ILE n 1 500 SER n 1 501 PRO n # _entity_src_nat.entity_id 1 _entity_src_nat.pdbx_src_id 1 _entity_src_nat.pdbx_alt_source_flag sample _entity_src_nat.pdbx_beg_seq_num ? _entity_src_nat.pdbx_end_seq_num ? _entity_src_nat.common_name 'WHITE MUSTARD' _entity_src_nat.pdbx_organism_scientific 'SINAPIS ALBA' _entity_src_nat.pdbx_ncbi_taxonomy_id 3728 _entity_src_nat.genus ? _entity_src_nat.species ? _entity_src_nat.strain EMERGO _entity_src_nat.tissue 'MYROSIN GRAINS' _entity_src_nat.tissue_fraction ? _entity_src_nat.pdbx_secretion ? _entity_src_nat.pdbx_fragment ? _entity_src_nat.pdbx_variant ? _entity_src_nat.pdbx_cell_line ? _entity_src_nat.pdbx_atcc ? _entity_src_nat.pdbx_cellular_location ? _entity_src_nat.pdbx_organ SEED _entity_src_nat.pdbx_organelle ? _entity_src_nat.pdbx_cell ? _entity_src_nat.pdbx_plasmid_name ? _entity_src_nat.pdbx_plasmid_details ? _entity_src_nat.details ? # _struct_ref.id 1 _struct_ref.db_name PDB _struct_ref.db_code 1W9B _struct_ref.entity_id 1 _struct_ref.pdbx_seq_one_letter_code ? _struct_ref.pdbx_align_begin ? _struct_ref.pdbx_db_accession 1W9B _struct_ref.pdbx_db_isoform ? # _struct_ref_seq.align_id 1 _struct_ref_seq.ref_id 1 _struct_ref_seq.pdbx_PDB_id_code 1W9B _struct_ref_seq.pdbx_strand_id M _struct_ref_seq.seq_align_beg 1 _struct_ref_seq.pdbx_seq_align_beg_ins_code ? _struct_ref_seq.seq_align_end 501 _struct_ref_seq.pdbx_seq_align_end_ins_code ? _struct_ref_seq.pdbx_db_accession 1W9B _struct_ref_seq.db_align_beg 1 _struct_ref_seq.pdbx_db_align_beg_ins_code ? _struct_ref_seq.db_align_end 501 _struct_ref_seq.pdbx_db_align_end_ins_code ? _struct_ref_seq.pdbx_auth_seq_align_beg 1 _struct_ref_seq.pdbx_auth_seq_align_end 501 # loop_ _chem_comp.id _chem_comp.type _chem_comp.mon_nstd_flag _chem_comp.name _chem_comp.pdbx_synonyms _chem_comp.formula _chem_comp.formula_weight ALA 'L-peptide linking' y ALANINE ? 'C3 H7 N O2' 89.093 ARG 'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1' 175.209 ASN 'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3' 132.118 ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4' 133.103 BMA D-saccharide . BETA-D-MANNOSE ? 'C6 H12 O6' 180.156 CGT non-polymer . CARBA-GLUCOTROPAEOLIN '(1S,2S,3R,4S,5S)-2,3,4-TRIHYDROXY-5-(HYDROXYMETHYL)CYCLOHEXYL (1E)-2-PHENYL-N-(SULFOOXY)ETHANIMIDOTHIOATE' 'C15 H21 N O8 S2' 407.459 CYS 'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S' 121.158 FUC saccharide . ALPHA-L-FUCOSE ? 'C6 H12 O5' 164.156 GLN 'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3' 146.144 GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4' 147.129 GLY 'peptide linking' y GLYCINE ? 'C2 H5 N O2' 75.067 GOL non-polymer . GLYCEROL 'GLYCERIN; PROPANE-1,2,3-TRIOL' 'C3 H8 O3' 92.094 HIS 'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1' 156.162 HOH non-polymer . WATER ? 'H2 O' 18.015 ILE 'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2' 131.173 LEU 'L-peptide linking' y LEUCINE ? 'C6 H13 N O2' 131.173 LYS 'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1' 147.195 MAN D-saccharide . ALPHA-D-MANNOSE ? 'C6 H12 O6' 180.156 MET 'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S' 149.211 NAG D-saccharide . N-ACETYL-D-GLUCOSAMINE ? 'C8 H15 N O6' 221.208 PHE 'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2' 165.189 PRO 'L-peptide linking' y PROLINE ? 'C5 H9 N O2' 115.130 SER 'L-peptide linking' y SERINE ? 'C3 H7 N O3' 105.093 SO4 non-polymer . 'SULFATE ION' ? 'O4 S -2' 96.063 THR 'L-peptide linking' y THREONINE ? 'C4 H9 N O3' 119.119 TRP 'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2' 204.225 TYR 'L-peptide linking' y TYROSINE ? 'C9 H11 N O3' 181.189 VAL 'L-peptide linking' y VALINE ? 'C5 H11 N O2' 117.146 XYP D-saccharide . BETA-D-XYLOPYRANOSE ? 'C5 H10 O5' 150.130 ZN non-polymer . 'ZINC ION' ? 'Zn 2' 65.409 # _exptl.entry_id 1W9B _exptl.method 'X-RAY DIFFRACTION' _exptl.crystals_number 1 # _exptl_crystal.id 1 _exptl_crystal.density_meas ? _exptl_crystal.density_Matthews 3.2 _exptl_crystal.density_percent_sol 50 _exptl_crystal.description ? # _exptl_crystal_grow.crystal_id 1 _exptl_crystal_grow.method ? _exptl_crystal_grow.temp ? _exptl_crystal_grow.temp_details ? _exptl_crystal_grow.pH 7.00 _exptl_crystal_grow.pdbx_pH_range ? _exptl_crystal_grow.pdbx_details ;HANGING DROP METHOD, 12 MG/ML PROTEIN IN 30 MM HEPES, PH 6.5, 0.05 % NAN3, PRECIPITANT 66% SAT. AMMONIUM SULFATE, 100MM TRIS-HCL PH 7.0 ; # _diffrn.id 1 _diffrn.ambient_temp 100.0 _diffrn.ambient_temp_details ? _diffrn.crystal_id 1 # _diffrn_detector.diffrn_id 1 _diffrn_detector.detector CCD _diffrn_detector.type MARRESEARCH _diffrn_detector.pdbx_collection_date 2002-09-27 _diffrn_detector.details 'TOROIDAL MIRROR' # _diffrn_radiation.diffrn_id 1 _diffrn_radiation.wavelength_id 1 _diffrn_radiation.pdbx_monochromatic_or_laue_m_l M _diffrn_radiation.monochromator 'DIAMOND 111 AND SI 220' _diffrn_radiation.pdbx_diffrn_protocol 'SINGLE WAVELENGTH' _diffrn_radiation.pdbx_scattering_type x-ray # _diffrn_radiation_wavelength.id 1 _diffrn_radiation_wavelength.wavelength 0.931 _diffrn_radiation_wavelength.wt 1.0 # _diffrn_source.diffrn_id 1 _diffrn_source.source SYNCHROTRON _diffrn_source.type 'ESRF BEAMLINE ID14-2' _diffrn_source.pdbx_synchrotron_site ESRF _diffrn_source.pdbx_synchrotron_beamline ID14-2 _diffrn_source.pdbx_wavelength 0.931 _diffrn_source.pdbx_wavelength_list ? # _reflns.pdbx_diffrn_id 1 _reflns.pdbx_ordinal 1 _reflns.entry_id 1W9B _reflns.observed_criterion_sigma_I ? _reflns.observed_criterion_sigma_F ? _reflns.d_resolution_low 97.000 _reflns.d_resolution_high 1.700 _reflns.number_obs 82052 _reflns.number_all ? _reflns.percent_possible_obs 98.2 _reflns.pdbx_Rmerge_I_obs 0.07000 _reflns.pdbx_Rsym_value ? _reflns.pdbx_netI_over_sigmaI ? _reflns.B_iso_Wilson_estimate ? _reflns.pdbx_redundancy 3.000 # _reflns_shell.pdbx_diffrn_id 1 _reflns_shell.pdbx_ordinal 1 _reflns_shell.d_res_high 1.70 _reflns_shell.d_res_low 1.76 _reflns_shell.percent_possible_all 98.1 _reflns_shell.Rmerge_I_obs ? _reflns_shell.pdbx_Rsym_value ? _reflns_shell.meanI_over_sigI_obs ? _reflns_shell.pdbx_redundancy ? # _refine.pdbx_refine_id 'X-RAY DIFFRACTION' _refine.entry_id 1W9B _refine.pdbx_diffrn_id 1 _refine.pdbx_TLS_residual_ADP_flag ? _refine.ls_number_reflns_obs 80337 _refine.ls_number_reflns_all ? _refine.pdbx_ls_sigma_I ? _refine.pdbx_ls_sigma_F 0.0 _refine.pdbx_data_cutoff_high_absF 10000 _refine.pdbx_data_cutoff_low_absF ? _refine.pdbx_data_cutoff_high_rms_absF ? _refine.ls_d_res_low 97 _refine.ls_d_res_high 1.7 _refine.ls_percent_reflns_obs 97.4 _refine.ls_R_factor_obs 0.175 _refine.ls_R_factor_all ? _refine.ls_R_factor_R_work 0.175 _refine.ls_R_factor_R_free 0.191 _refine.ls_R_factor_R_free_error 0.003 _refine.ls_R_factor_R_free_error_details ? _refine.ls_percent_reflns_R_free 4.9 _refine.ls_number_reflns_R_free 4055 _refine.ls_number_parameters ? _refine.ls_number_restraints ? _refine.occupancy_min ? _refine.occupancy_max ? _refine.correlation_coeff_Fo_to_Fc ? _refine.correlation_coeff_Fo_to_Fc_free ? _refine.B_iso_mean 19.4 _refine.aniso_B[1][1] 0.768 _refine.aniso_B[2][2] -0.351 _refine.aniso_B[3][3] -0.417 _refine.aniso_B[1][2] 0.000 _refine.aniso_B[1][3] 0.000 _refine.aniso_B[2][3] 0.000 _refine.solvent_model_details 'FLAT MODEL' _refine.solvent_model_param_ksol 0.376585 _refine.solvent_model_param_bsol 38.7848 _refine.pdbx_solvent_vdw_probe_radii ? _refine.pdbx_solvent_ion_probe_radii ? _refine.pdbx_solvent_shrinkage_radii ? _refine.pdbx_ls_cross_valid_method THROUGHOUT _refine.details ? _refine.pdbx_starting_model 'PDB ENTRY 1E4M' _refine.pdbx_method_to_determine_struct 'MOLECULAR REPLACEMENT' _refine.pdbx_isotropic_thermal_model RESTRAINED _refine.pdbx_stereochemistry_target_values ? _refine.pdbx_stereochem_target_val_spec_case ? _refine.pdbx_R_Free_selection_details RANDOM _refine.pdbx_overall_ESU_R ? _refine.pdbx_overall_ESU_R_Free ? _refine.overall_SU_ML ? _refine.pdbx_overall_phase_error ? _refine.overall_SU_B ? _refine.overall_SU_R_Cruickshank_DPI ? _refine.pdbx_overall_SU_R_free_Cruickshank_DPI ? _refine.pdbx_overall_SU_R_Blow_DPI ? _refine.pdbx_overall_SU_R_free_Blow_DPI ? # _refine_analyze.pdbx_refine_id 'X-RAY DIFFRACTION' _refine_analyze.entry_id 1W9B _refine_analyze.Luzzati_coordinate_error_obs 0.16 _refine_analyze.Luzzati_sigma_a_obs 0.07 _refine_analyze.Luzzati_d_res_low_obs 5 _refine_analyze.Luzzati_coordinate_error_free 0.18 _refine_analyze.Luzzati_sigma_a_free 0.09 _refine_analyze.Luzzati_d_res_low_free ? _refine_analyze.number_disordered_residues ? _refine_analyze.occupancy_sum_hydrogen ? _refine_analyze.occupancy_sum_non_hydrogen ? # _refine_hist.pdbx_refine_id 'X-RAY DIFFRACTION' _refine_hist.cycle_id LAST _refine_hist.pdbx_number_atoms_protein 4016 _refine_hist.pdbx_number_atoms_nucleic_acid 0 _refine_hist.pdbx_number_atoms_ligand 344 _refine_hist.number_atoms_solvent 764 _refine_hist.number_atoms_total 5124 _refine_hist.d_res_high 1.7 _refine_hist.d_res_low 97 # loop_ _refine_ls_restr.type _refine_ls_restr.dev_ideal _refine_ls_restr.dev_ideal_target _refine_ls_restr.weight _refine_ls_restr.number _refine_ls_restr.pdbx_refine_id _refine_ls_restr.pdbx_restraint_function c_bond_d 0.0083 ? ? ? 'X-RAY DIFFRACTION' ? c_bond_d_na ? ? ? ? 'X-RAY DIFFRACTION' ? c_bond_d_prot ? ? ? ? 'X-RAY DIFFRACTION' ? c_angle_d ? ? ? ? 'X-RAY DIFFRACTION' ? c_angle_d_na ? ? ? ? 'X-RAY DIFFRACTION' ? c_angle_d_prot ? ? ? ? 'X-RAY DIFFRACTION' ? c_angle_deg 1.47 ? ? ? 'X-RAY DIFFRACTION' ? c_angle_deg_na ? ? ? ? 'X-RAY DIFFRACTION' ? c_angle_deg_prot ? ? ? ? 'X-RAY DIFFRACTION' ? c_dihedral_angle_d 22.7 ? ? ? 'X-RAY DIFFRACTION' ? c_dihedral_angle_d_na ? ? ? ? 'X-RAY DIFFRACTION' ? c_dihedral_angle_d_prot ? ? ? ? 'X-RAY DIFFRACTION' ? c_improper_angle_d 1.46 ? ? ? 'X-RAY DIFFRACTION' ? c_improper_angle_d_na ? ? ? ? 'X-RAY DIFFRACTION' ? c_improper_angle_d_prot ? ? ? ? 'X-RAY DIFFRACTION' ? c_mcbond_it 1.48 2.5 ? ? 'X-RAY DIFFRACTION' ? c_mcangle_it 2.42 3.0 ? ? 'X-RAY DIFFRACTION' ? c_scbond_it 2.16 3.0 ? ? 'X-RAY DIFFRACTION' ? c_scangle_it 3.5 3.5 ? ? 'X-RAY DIFFRACTION' ? # _refine_ls_shell.pdbx_refine_id 'X-RAY DIFFRACTION' _refine_ls_shell.pdbx_total_number_of_bins_used 10 _refine_ls_shell.d_res_high 1.7 _refine_ls_shell.d_res_low 1.76 _refine_ls_shell.number_reflns_R_work 7590 _refine_ls_shell.R_factor_R_work 0.2022 _refine_ls_shell.percent_reflns_obs 0.981 _refine_ls_shell.R_factor_R_free 0.22 _refine_ls_shell.R_factor_R_free_error 0.02 _refine_ls_shell.percent_reflns_R_free 4.97 _refine_ls_shell.number_reflns_R_free 405 _refine_ls_shell.number_reflns_all ? _refine_ls_shell.R_factor_all ? # loop_ _pdbx_xplor_file.pdbx_refine_id _pdbx_xplor_file.serial_no _pdbx_xplor_file.param_file _pdbx_xplor_file.topol_file 'X-RAY DIFFRACTION' 1 PROTEIN.PARAM PROTEIN.TOP 'X-RAY DIFFRACTION' 2 WATER.PARAM WATER.TOP 'X-RAY DIFFRACTION' 3 CGT_PAR.TXT.PAR CGT_TOP.TXT.TOP 'X-RAY DIFFRACTION' 4 CARBOHYDRATE.PARAM CARBOHYDRATE.TOP 'X-RAY DIFFRACTION' 5 ION.PARAM ION.TOP # _struct.entry_id 1W9B _struct.title 'S. alba myrosinase in complex with carba-glucotropaeolin' _struct.pdbx_descriptor 'GLYCOSIDASE (E.C.3.2.3.1)' _struct.pdbx_model_details ? _struct.pdbx_CASP_flag ? _struct.pdbx_model_type_details ? # _struct_keywords.entry_id 1W9B _struct_keywords.pdbx_keywords HYDROLASE _struct_keywords.text 'THIOGLUCOSIDASE, THIOGLYCOSIDASE, MYROSINASE, HYDROLASE, THIO-GLUCOSIDE, THIOHYDROXIMATE, GLUSOSINOLATE, GLUCOTROPAEOLIN' # loop_ _struct_asym.id _struct_asym.pdbx_blank_PDB_chainid_flag _struct_asym.pdbx_modified _struct_asym.entity_id _struct_asym.details A N N 1 ? B N N 2 ? C N N 2 ? D N N 2 ? E N N 2 ? F N N 2 ? G N N 2 ? H N N 3 ? I N N 2 ? J N N 4 ? K N N 5 ? L N N 2 ? M N N 3 ? N N N 2 ? O N N 4 ? P N N 5 ? Q N N 6 ? R N N 6 ? S N N 2 ? T N N 2 ? U N N 2 ? V N N 2 ? W N N 2 ? X N N 7 ? Y N N 8 ? Z N N 9 ? AA N N 10 ? BA N N 10 ? CA N N 10 ? DA N N 10 ? EA N N 8 ? FA N N 8 ? GA N N 11 ? # _struct_biol.id 1 # loop_ _struct_conf.conf_type_id _struct_conf.id _struct_conf.pdbx_PDB_helix_id _struct_conf.beg_label_comp_id _struct_conf.beg_label_asym_id _struct_conf.beg_label_seq_id _struct_conf.pdbx_beg_PDB_ins_code _struct_conf.end_label_comp_id _struct_conf.end_label_asym_id _struct_conf.end_label_seq_id _struct_conf.pdbx_end_PDB_ins_code _struct_conf.beg_auth_comp_id _struct_conf.beg_auth_asym_id _struct_conf.beg_auth_seq_id _struct_conf.end_auth_comp_id _struct_conf.end_auth_asym_id _struct_conf.end_auth_seq_id _struct_conf.pdbx_PDB_helix_class _struct_conf.details _struct_conf.pdbx_PDB_helix_length HELX_P HELX_P1 1 ASN A 21 ? PHE A 25 ? ASN M 21 PHE M 25 5 ? 5 HELX_P HELX_P2 2 SER A 36 ? GLU A 41 ? SER M 36 GLU M 41 1 ? 6 HELX_P HELX_P3 3 ASN A 49 ? TYR A 58 ? ASN M 49 TYR M 58 1 ? 10 HELX_P HELX_P4 4 TYR A 58 ? GLY A 63 ? TYR M 58 GLY M 63 1 ? 6 HELX_P HELX_P5 5 ASP A 74 ? ASN A 90 ? ASP M 74 ASN M 90 1 ? 17 HELX_P HELX_P6 6 ALA A 99 ? ILE A 104 ? ALA M 99 ILE M 104 1 ? 6 HELX_P HELX_P7 7 LYS A 108 ? GLY A 112 ? LYS M 108 GLY M 112 5 ? 5 HELX_P HELX_P8 8 ASN A 114 ? LYS A 131 ? ASN M 114 LYS M 131 1 ? 18 HELX_P HELX_P9 9 PRO A 145 ? GLU A 153 ? PRO M 145 GLU M 153 1 ? 9 HELX_P HELX_P10 10 GLY A 154 ? PRO A 158 ? GLY M 154 PRO M 158 5 ? 5 HELX_P HELX_P11 11 GLN A 159 ? GLY A 176 ? GLN M 159 GLY M 176 1 ? 18 HELX_P HELX_P12 12 TYR A 189 ? GLY A 197 ? TYR M 189 GLY M 197 1 ? 9 HELX_P HELX_P13 13 THR A 221 ? TYR A 245 ? THR M 221 TYR M 245 1 ? 25 HELX_P HELX_P14 14 THR A 246 ? GLY A 249 ? THR M 246 GLY M 249 5 ? 4 HELX_P HELX_P15 15 ASP A 268 ? LEU A 283 ? ASP M 268 LEU M 283 1 ? 16 HELX_P HELX_P16 16 LEU A 283 ? GLY A 293 ? LEU M 283 GLY M 293 1 ? 11 HELX_P HELX_P17 17 PRO A 296 ? GLY A 304 ? PRO M 296 GLY M 304 1 ? 9 HELX_P HELX_P18 18 GLU A 305 ? LEU A 307 ? GLU M 305 LEU M 307 5 ? 3 HELX_P HELX_P19 19 SER A 311 ? LYS A 319 ? SER M 311 LYS M 319 1 ? 9 HELX_P HELX_P20 20 THR A 348 ? ALA A 353 ? THR M 348 ALA M 353 5 ? 6 HELX_P HELX_P21 21 ASP A 377 ? ASN A 381 ? ASP M 377 ASN M 381 5 ? 5 HELX_P HELX_P22 22 PRO A 386 ? TYR A 400 ? PRO M 386 TYR M 400 1 ? 15 HELX_P HELX_P23 23 ASN A 419 ? LEU A 425 ? ASN M 419 LEU M 425 1 ? 7 HELX_P HELX_P24 24 ASP A 426 ? ASP A 448 ? ASP M 426 ASP M 448 1 ? 23 HELX_P HELX_P25 25 LYS A 489 ? SER A 500 ? LYS M 489 SER M 500 1 ? 12 # _struct_conf_type.id HELX_P _struct_conf_type.criteria ? _struct_conf_type.reference ? # loop_ _struct_conn.id _struct_conn.conn_type_id _struct_conn.pdbx_leaving_atom_flag _struct_conn.pdbx_PDB_id _struct_conn.ptnr1_label_asym_id _struct_conn.ptnr1_label_comp_id _struct_conn.ptnr1_label_seq_id _struct_conn.ptnr1_label_atom_id _struct_conn.pdbx_ptnr1_label_alt_id _struct_conn.pdbx_ptnr1_PDB_ins_code _struct_conn.pdbx_ptnr1_standard_comp_id _struct_conn.ptnr1_symmetry _struct_conn.ptnr2_label_asym_id _struct_conn.ptnr2_label_comp_id _struct_conn.ptnr2_label_seq_id _struct_conn.ptnr2_label_atom_id _struct_conn.pdbx_ptnr2_label_alt_id _struct_conn.pdbx_ptnr2_PDB_ins_code _struct_conn.ptnr1_auth_asym_id _struct_conn.ptnr1_auth_comp_id _struct_conn.ptnr1_auth_seq_id _struct_conn.ptnr2_auth_asym_id _struct_conn.ptnr2_auth_comp_id _struct_conn.ptnr2_auth_seq_id _struct_conn.ptnr2_symmetry _struct_conn.pdbx_ptnr3_label_atom_id _struct_conn.pdbx_ptnr3_label_seq_id _struct_conn.pdbx_ptnr3_label_comp_id _struct_conn.pdbx_ptnr3_label_asym_id _struct_conn.pdbx_ptnr3_label_alt_id _struct_conn.pdbx_ptnr3_PDB_ins_code _struct_conn.details _struct_conn.pdbx_dist_value _struct_conn.pdbx_value_order disulf1 disulf ? ? A CYS 6 SG ? ? ? 1_555 A CYS 438 SG ? ? M CYS 6 M CYS 438 1_555 ? ? ? ? ? ? ? 2.044 ? disulf2 disulf ? ? A CYS 14 SG ? ? ? 1_555 A CYS 434 SG ? ? M CYS 14 M CYS 434 1_555 ? ? ? ? ? ? ? 2.042 ? disulf3 disulf ? ? A CYS 206 SG ? ? ? 1_555 A CYS 214 SG ? ? M CYS 206 M CYS 214 1_555 ? ? ? ? ? ? ? 2.032 ? covale1 covale ? ? A ASN 21 ND2 ? ? ? 1_555 B NAG . C1 ? ? M ASN 21 M NAG 901 1_555 ? ? ? ? ? ? ? 1.451 ? covale2 covale ? ? A ASN 90 ND2 ? ? ? 1_555 C NAG . C1 ? ? M ASN 90 M NAG 911 1_555 ? ? ? ? ? ? ? 1.451 ? covale3 covale ? ? A ASN 218 ND2 ? ? ? 1_555 D NAG . C1 ? ? M ASN 218 M NAG 921 1_555 ? ? ? ? ? ? ? 1.449 ? covale4 covale ? ? A ASN 244 ND2 ? ? ? 1_555 F NAG . C1 ? ? M ASN 244 M NAG 931 1_555 ? ? ? ? ? ? ? 1.449 ? covale5 covale ? ? A ASN 265 ND2 ? ? ? 1_555 G NAG . C1 ? ? M ASN 265 M NAG 941 1_555 ? ? ? ? ? ? ? 1.448 ? covale6 covale ? ? A ASN 292 ND2 ? ? ? 1_555 L NAG . C1 ? ? M ASN 292 M NAG 951 1_555 ? ? ? ? ? ? ? 1.447 ? covale7 covale ? ? A ASN 346 ND2 ? ? ? 1_555 T NAG . C1 ? ? M ASN 346 M NAG 971 1_555 ? ? ? ? ? ? ? 1.454 ? covale8 covale ? ? A ASN 361 ND2 ? ? ? 1_555 U NAG . C1 ? ? M ASN 361 M NAG 981 1_555 ? ? ? ? ? ? ? 1.449 ? covale9 covale ? ? A GLU 464 OE2 B ? ? 1_555 X CGT . O6 ? ? M GLU 464 M CGT 999 1_555 ? ? ? ? ? ? ? 1.732 ? covale10 covale ? ? A GLU 464 OE1 B ? ? 1_555 X CGT . O6 ? ? M GLU 464 M CGT 999 1_555 ? ? ? ? ? ? ? 2.045 ? covale11 covale ? ? A GLU 464 CD B ? ? 1_555 X CGT . O6 ? ? M GLU 464 M CGT 999 1_555 ? ? ? ? ? ? ? 1.722 ? covale12 covale ? ? A GLU 464 CD B ? ? 1_555 X CGT . C6 ? ? M GLU 464 M CGT 999 1_555 ? ? ? ? ? ? ? 1.734 ? covale13 covale ? ? A ASN 482 ND2 ? ? ? 1_555 W NAG . C1 ? ? M ASN 482 M NAG 991 1_555 ? ? ? ? ? ? ? 1.449 ? covale14 covale ? ? D NAG . O4 ? ? ? 1_555 E NAG . C1 ? ? M NAG 921 M NAG 923 1_555 ? ? ? ? ? ? ? 1.383 ? covale15 covale ? ? G NAG . O3 ? ? ? 1_555 H FUC . C1 ? ? M NAG 941 M FUC 942 1_555 ? ? ? ? ? ? ? 1.397 ? covale16 covale ? ? G NAG . O4 ? ? ? 1_555 I NAG . C1 ? ? M NAG 941 M NAG 943 1_555 ? ? ? ? ? ? ? 1.383 ? covale17 covale ? ? I NAG . O4 ? ? ? 1_555 J BMA . C1 ? ? M NAG 943 M BMA 944 1_555 ? ? ? ? ? ? ? 1.386 ? covale18 covale ? ? J BMA . O2 ? ? ? 1_555 K XYP . C1B ? ? M BMA 944 M XYP 945 1_555 ? ? ? ? ? ? ? 1.385 ? covale19 covale ? ? L NAG . O3 ? ? ? 1_555 M FUC . C1 ? ? M NAG 951 M FUC 952 1_555 ? ? ? ? ? ? ? 1.396 ? covale20 covale ? ? L NAG . O4 ? ? ? 1_555 N NAG . C1 ? ? M NAG 951 M NAG 953 1_555 ? ? ? ? ? ? ? 1.380 ? covale21 covale ? ? N NAG . O4 ? ? ? 1_555 O BMA . C1 ? ? M NAG 953 M BMA 954 1_555 ? ? ? ? ? ? ? 1.379 ? covale22 covale ? ? O BMA . O2 ? ? ? 1_555 P XYP . C1B ? ? M BMA 954 M XYP 955 1_555 ? ? ? ? ? ? ? 1.385 ? covale23 covale ? ? O BMA . O3 ? ? ? 1_555 Q MAN . C1 ? ? M BMA 954 M MAN 956 1_555 ? ? ? ? ? ? ? 1.398 ? covale24 covale ? ? O BMA . O6 ? ? ? 1_555 R MAN . C1 ? ? M BMA 954 M MAN 957 1_555 ? ? ? ? ? ? ? 1.399 ? covale25 covale ? ? U NAG . O4 ? ? ? 1_555 V NAG . C1 ? ? M NAG 981 M NAG 983 1_555 ? ? ? ? ? ? ? 1.393 ? covale26 covale ? ? X CGT . O3 ? ? ? 1_555 Y GOL . C1 ? ? M CGT 999 M GOL 1000 1_555 ? ? ? ? ? ? ? 1.631 ? covale27 covale ? ? X CGT . O3 ? ? ? 1_555 Y GOL . C2 ? ? M CGT 999 M GOL 1000 1_555 ? ? ? ? ? ? ? 1.407 ? covale28 covale ? ? X CGT . C4 ? ? ? 1_555 Y GOL . C1 ? ? M CGT 999 M GOL 1000 1_555 ? ? ? ? ? ? ? 1.499 ? covale29 covale ? ? X CGT . C4 ? ? ? 1_555 Y GOL . O1 ? ? M CGT 999 M GOL 1000 1_555 ? ? ? ? ? ? ? 1.756 ? covale30 covale ? ? X CGT . O4 ? ? ? 1_555 Y GOL . O1 ? ? M CGT 999 M GOL 1000 1_555 ? ? ? ? ? ? ? 1.743 ? covale31 covale ? ? X CGT . C3 ? ? ? 1_555 Y GOL . C1 ? ? M CGT 999 M GOL 1000 1_555 ? ? ? ? ? ? ? 1.630 ? metalc1 metalc ? ? Z ZN . ZN ? ? ? 1_555 A ASP 70 OD2 ? ? M ZN 1502 M ASP 70 3_656 ? ? ? ? ? ? ? 2.097 ? metalc2 metalc ? ? Z ZN . ZN ? ? ? 1_555 A ASP 70 OD2 ? ? M ZN 1502 M ASP 70 1_555 ? ? ? ? ? ? ? 2.049 ? metalc3 metalc ? ? Z ZN . ZN ? ? ? 1_555 A HIS 56 NE2 ? ? M ZN 1502 M HIS 56 3_656 ? ? ? ? ? ? ? 2.001 ? metalc4 metalc ? ? Z ZN . ZN ? ? ? 1_555 A HIS 56 NE2 ? ? M ZN 1502 M HIS 56 1_555 ? ? ? ? ? ? ? 2.040 ? # loop_ _struct_conn_type.id _struct_conn_type.criteria _struct_conn_type.reference disulf ? ? covale ? ? metalc ? ? # loop_ _struct_mon_prot_cis.pdbx_id _struct_mon_prot_cis.label_comp_id _struct_mon_prot_cis.label_seq_id _struct_mon_prot_cis.label_asym_id _struct_mon_prot_cis.label_alt_id _struct_mon_prot_cis.pdbx_PDB_ins_code _struct_mon_prot_cis.auth_comp_id _struct_mon_prot_cis.auth_seq_id _struct_mon_prot_cis.auth_asym_id _struct_mon_prot_cis.pdbx_label_comp_id_2 _struct_mon_prot_cis.pdbx_label_seq_id_2 _struct_mon_prot_cis.pdbx_label_asym_id_2 _struct_mon_prot_cis.pdbx_PDB_ins_code_2 _struct_mon_prot_cis.pdbx_auth_comp_id_2 _struct_mon_prot_cis.pdbx_auth_seq_id_2 _struct_mon_prot_cis.pdbx_auth_asym_id_2 _struct_mon_prot_cis.pdbx_PDB_model_num _struct_mon_prot_cis.pdbx_omega_angle 1 LEU 10 A . ? LEU 10 M PRO 11 A ? PRO 11 M 1 -0.71 2 ALA 202 A . ? ALA 202 M PRO 203 A ? PRO 203 M 1 1.10 # loop_ _struct_sheet.id _struct_sheet.type _struct_sheet.number_strands _struct_sheet.details MA ? 9 ? MB ? 9 ? MC ? 2 ? MD ? 2 ? ME ? 2 ? # loop_ _struct_sheet_order.sheet_id _struct_sheet_order.range_id_1 _struct_sheet_order.range_id_2 _struct_sheet_order.offset _struct_sheet_order.sense MA 1 2 ? parallel MA 2 3 ? parallel MA 3 4 ? parallel MA 4 5 ? parallel MA 5 6 ? parallel MA 6 7 ? parallel MA 7 8 ? parallel MA 8 9 ? parallel MB 1 2 ? parallel MB 2 3 ? parallel MB 3 4 ? parallel MB 4 5 ? parallel MB 5 6 ? parallel MB 6 7 ? parallel MB 7 8 ? parallel MB 8 9 ? anti-parallel MC 1 2 ? anti-parallel MD 1 2 ? anti-parallel ME 1 2 ? anti-parallel # loop_ _struct_sheet_range.sheet_id _struct_sheet_range.id _struct_sheet_range.beg_label_comp_id _struct_sheet_range.beg_label_asym_id _struct_sheet_range.beg_label_seq_id _struct_sheet_range.pdbx_beg_PDB_ins_code _struct_sheet_range.end_label_comp_id _struct_sheet_range.end_label_asym_id _struct_sheet_range.end_label_seq_id _struct_sheet_range.pdbx_end_PDB_ins_code _struct_sheet_range.beg_auth_comp_id _struct_sheet_range.beg_auth_asym_id _struct_sheet_range.beg_auth_seq_id _struct_sheet_range.end_auth_comp_id _struct_sheet_range.end_auth_asym_id _struct_sheet_range.end_auth_seq_id MA 1 LYS A 251 ? GLY A 253 ? LYS M 251 GLY M 253 MA 2 TYR A 181 ? ILE A 185 ? TYR M 181 ILE M 185 MA 3 THR A 134 ? PHE A 140 ? THR M 134 PHE M 140 MA 4 GLY A 93 ? SER A 97 ? GLY M 93 SER M 97 MA 5 ILE A 30 ? ALA A 34 ? ILE M 30 ALA M 34 MA 6 VAL A 451 ? TRP A 457 ? VAL M 451 TRP M 457 MA 7 ILE A 405 ? GLU A 409 ? ILE M 405 GLU M 409 MA 8 LEU A 325 ? PRO A 337 ? LEU M 325 PRO M 337 MA 9 THR A 255 ? PRO A 263 ? THR M 255 PRO M 263 MB 1 LYS A 251 ? GLY A 253 ? LYS M 251 GLY M 253 MB 2 TYR A 181 ? ILE A 185 ? TYR M 181 ILE M 185 MB 3 THR A 134 ? PHE A 140 ? THR M 134 PHE M 140 MB 4 GLY A 93 ? SER A 97 ? GLY M 93 SER M 97 MB 5 ILE A 30 ? ALA A 34 ? ILE M 30 ALA M 34 MB 6 VAL A 451 ? TRP A 457 ? VAL M 451 TRP M 457 MB 7 ILE A 405 ? GLU A 409 ? ILE M 405 GLU M 409 MB 8 LEU A 325 ? PRO A 337 ? LEU M 325 PRO M 337 MB 9 ALA A 355 ? THR A 358 ? ALA M 355 THR M 358 MC 1 LEU A 370 ? GLU A 372 ? LEU M 370 GLU M 372 MC 2 ILE A 382 ? TYR A 383 ? ILE M 382 TYR M 383 MD 1 THR A 414 ? PRO A 415 ? THR M 414 PRO M 415 MD 2 VAL A 471 ? ARG A 472 ? VAL M 471 ARG M 472 ME 1 SER A 476 ? ASP A 479 ? SER M 476 ASP M 479 ME 2 ASN A 482 ? LEU A 488 ? ASN M 482 LEU M 488 # loop_ _pdbx_struct_sheet_hbond.sheet_id _pdbx_struct_sheet_hbond.range_id_1 _pdbx_struct_sheet_hbond.range_id_2 _pdbx_struct_sheet_hbond.range_1_label_atom_id _pdbx_struct_sheet_hbond.range_1_label_comp_id _pdbx_struct_sheet_hbond.range_1_label_asym_id _pdbx_struct_sheet_hbond.range_1_label_seq_id _pdbx_struct_sheet_hbond.range_1_PDB_ins_code _pdbx_struct_sheet_hbond.range_1_auth_atom_id _pdbx_struct_sheet_hbond.range_1_auth_comp_id _pdbx_struct_sheet_hbond.range_1_auth_asym_id _pdbx_struct_sheet_hbond.range_1_auth_seq_id _pdbx_struct_sheet_hbond.range_2_label_atom_id _pdbx_struct_sheet_hbond.range_2_label_comp_id _pdbx_struct_sheet_hbond.range_2_label_asym_id _pdbx_struct_sheet_hbond.range_2_label_seq_id _pdbx_struct_sheet_hbond.range_2_PDB_ins_code _pdbx_struct_sheet_hbond.range_2_auth_atom_id _pdbx_struct_sheet_hbond.range_2_auth_comp_id _pdbx_struct_sheet_hbond.range_2_auth_asym_id _pdbx_struct_sheet_hbond.range_2_auth_seq_id MA 1 2 N GLY A 253 ? N GLY M 253 O TRP A 182 ? O TRP M 182 MA 2 3 N LEU A 183 ? N LEU M 183 O VAL A 137 ? O VAL M 137 MA 3 4 N PHE A 136 ? N PHE M 136 O TYR A 94 ? O TYR M 94 MA 4 5 N ARG A 95 ? N ARG M 95 O VAL A 33 ? O VAL M 33 MA 5 6 N ILE A 30 ? N ILE M 30 O LYS A 452 ? O LYS M 452 MA 6 7 N LYS A 452 ? N LYS M 452 O ILE A 405 ? O ILE M 405 MA 7 8 N TYR A 406 ? N TYR M 406 O LEU A 325 ? O LEU M 325 MA 8 9 N ASN A 328 ? N ASN M 328 O MET A 256 ? O MET M 256 MB 1 2 N GLY A 253 ? N GLY M 253 O TRP A 182 ? O TRP M 182 MB 2 3 N LEU A 183 ? N LEU M 183 O VAL A 137 ? O VAL M 137 MB 3 4 N PHE A 136 ? N PHE M 136 O TYR A 94 ? O TYR M 94 MB 4 5 N ARG A 95 ? N ARG M 95 O VAL A 33 ? O VAL M 33 MB 5 6 N ILE A 30 ? N ILE M 30 O LYS A 452 ? O LYS M 452 MB 6 7 N LYS A 452 ? N LYS M 452 O ILE A 405 ? O ILE M 405 MB 7 8 N TYR A 406 ? N TYR M 406 O LEU A 325 ? O LEU M 325 MB 8 9 N GLN A 336 ? N GLN M 336 O LYS A 356 ? O LYS M 356 MC 1 2 N PHE A 371 ? N PHE M 371 O ILE A 382 ? O ILE M 382 MD 1 2 N THR A 414 ? N THR M 414 O ARG A 472 ? O ARG M 472 ME 1 2 N ASP A 479 ? N ASP M 479 O ASN A 482 ? O ASN M 482 # loop_ _struct_site.id _struct_site.pdbx_evidence_code _struct_site.pdbx_auth_asym_id _struct_site.pdbx_auth_comp_id _struct_site.pdbx_auth_seq_id _struct_site.pdbx_auth_ins_code _struct_site.pdbx_num_residues _struct_site.details AC1 Software ? ? ? ? 8 'BINDING SITE FOR RESIDUE NAG M 901' AC2 Software ? ? ? ? 6 'BINDING SITE FOR RESIDUE NAG M 911' AC3 Software ? ? ? ? 8 'BINDING SITE FOR RESIDUE NAG M 921' AC4 Software ? ? ? ? 3 'BINDING SITE FOR RESIDUE NAG M 923' AC5 Software ? ? ? ? 4 'BINDING SITE FOR RESIDUE NAG M 931' AC6 Software ? ? ? ? 9 'BINDING SITE FOR RESIDUE NAG M 941' AC7 Software ? ? ? ? 2 'BINDING SITE FOR RESIDUE FUC M 942' AC8 Software ? ? ? ? 9 'BINDING SITE FOR RESIDUE NAG M 943' AC9 Software ? ? ? ? 2 'BINDING SITE FOR RESIDUE BMA M 944' BC1 Software ? ? ? ? 6 'BINDING SITE FOR RESIDUE XYP M 945' BC2 Software ? ? ? ? 9 'BINDING SITE FOR RESIDUE NAG M 951' BC3 Software ? ? ? ? 9 'BINDING SITE FOR RESIDUE FUC M 952' BC4 Software ? ? ? ? 11 'BINDING SITE FOR RESIDUE NAG M 953' BC5 Software ? ? ? ? 7 'BINDING SITE FOR RESIDUE BMA M 954' BC6 Software ? ? ? ? 5 'BINDING SITE FOR RESIDUE XYP M 955' BC7 Software ? ? ? ? 9 'BINDING SITE FOR RESIDUE MAN M 956' BC8 Software ? ? ? ? 8 'BINDING SITE FOR RESIDUE MAN M 957' BC9 Software ? ? ? ? 5 'BINDING SITE FOR RESIDUE NAG M 961' CC1 Software ? ? ? ? 3 'BINDING SITE FOR RESIDUE NAG M 971' CC2 Software ? ? ? ? 9 'BINDING SITE FOR RESIDUE NAG M 981' CC3 Software ? ? ? ? 5 'BINDING SITE FOR RESIDUE NAG M 983' CC4 Software ? ? ? ? 4 'BINDING SITE FOR RESIDUE NAG M 991' CC5 Software ? ? ? ? 2 'BINDING SITE FOR RESIDUE ZN M1502' CC6 Software ? ? ? ? 6 'BINDING SITE FOR RESIDUE SO4 M1503' CC7 Software ? ? ? ? 6 'BINDING SITE FOR RESIDUE SO4 M1504' CC8 Software ? ? ? ? 5 'BINDING SITE FOR RESIDUE SO4 M1505' CC9 Software ? ? ? ? 9 'BINDING SITE FOR RESIDUE SO4 M1506' DC1 Software ? ? ? ? 21 'BINDING SITE FOR RESIDUE CGT M 999' DC2 Software ? ? ? ? 11 'BINDING SITE FOR RESIDUE GOL M1000' DC3 Software ? ? ? ? 8 'BINDING SITE FOR RESIDUE GOL M1512' DC4 Software ? ? ? ? 11 'BINDING SITE FOR RESIDUE GOL M1513' # loop_ _struct_site_gen.id _struct_site_gen.site_id _struct_site_gen.pdbx_num_res _struct_site_gen.label_comp_id _struct_site_gen.label_asym_id _struct_site_gen.label_seq_id _struct_site_gen.pdbx_auth_ins_code _struct_site_gen.auth_comp_id _struct_site_gen.auth_asym_id _struct_site_gen.auth_seq_id _struct_site_gen.label_atom_id _struct_site_gen.label_alt_id _struct_site_gen.symmetry _struct_site_gen.details 1 AC1 8 THR A 17 ? THR M 17 . ? 1_555 ? 2 AC1 8 ASP A 18 ? ASP M 18 . ? 1_555 ? 3 AC1 8 ALA A 19 ? ALA M 19 . ? 1_555 ? 4 AC1 8 ASN A 21 ? ASN M 21 . ? 1_555 ? 5 AC1 8 SER A 24 ? SER M 24 . ? 1_555 ? 6 AC1 8 HOH GA . ? HOH M 2049 . ? 1_555 ? 7 AC1 8 HOH GA . ? HOH M 2672 . ? 1_555 ? 8 AC1 8 HOH GA . ? HOH M 2673 . ? 1_555 ? 9 AC2 6 ASN A 90 ? ASN M 90 . ? 1_555 ? 10 AC2 6 SER A 500 ? SER M 500 . ? 1_555 ? 11 AC2 6 MAN R . ? MAN M 957 . ? 1_555 ? 12 AC2 6 HOH GA . ? HOH M 2669 . ? 1_555 ? 13 AC2 6 HOH GA . ? HOH M 2674 . ? 1_555 ? 14 AC2 6 HOH GA . ? HOH M 2675 . ? 1_555 ? 15 AC3 8 ASN A 218 ? ASN M 218 . ? 1_555 ? 16 AC3 8 THR A 221 ? THR M 221 . ? 1_555 ? 17 AC3 8 NAG E . ? NAG M 923 . ? 1_555 ? 18 AC3 8 HOH GA . ? HOH M 2676 . ? 1_555 ? 19 AC3 8 HOH GA . ? HOH M 2677 . ? 1_555 ? 20 AC3 8 HOH GA . ? HOH M 2678 . ? 1_555 ? 21 AC3 8 HOH GA . ? HOH M 2679 . ? 1_555 ? 22 AC3 8 HOH GA . ? HOH M 2680 . ? 1_555 ? 23 AC4 3 GLU A 305 ? GLU M 305 . ? 1_555 ? 24 AC4 3 NAG D . ? NAG M 921 . ? 1_555 ? 25 AC4 3 HOH GA . ? HOH M 2681 . ? 1_555 ? 26 AC5 4 LYS A 165 ? LYS M 165 . ? 1_555 ? 27 AC5 4 LEU A 240 ? LEU M 240 . ? 1_555 ? 28 AC5 4 ASN A 244 ? ASN M 244 . ? 1_555 ? 29 AC5 4 HOH GA . ? HOH M 2684 . ? 1_555 ? 30 AC6 9 ASN A 265 ? ASN M 265 . ? 1_555 ? 31 AC6 9 ASP A 268 ? ASP M 268 . ? 1_555 ? 32 AC6 9 ALA A 362 ? ALA M 362 . ? 1_555 ? 33 AC6 9 FUC H . ? FUC M 942 . ? 1_555 ? 34 AC6 9 NAG I . ? NAG M 943 . ? 1_555 ? 35 AC6 9 HOH GA . ? HOH M 2685 . ? 1_555 ? 36 AC6 9 HOH GA . ? HOH M 2686 . ? 1_555 ? 37 AC6 9 HOH GA . ? HOH M 2687 . ? 1_555 ? 38 AC6 9 HOH GA . ? HOH M 2689 . ? 1_555 ? 39 AC7 2 NAG G . ? NAG M 941 . ? 1_555 ? 40 AC7 2 NAG I . ? NAG M 943 . ? 1_555 ? 41 AC8 9 ASN A 316 ? ASN M 316 . ? 1_555 ? 42 AC8 9 NAG G . ? NAG M 941 . ? 1_555 ? 43 AC8 9 FUC H . ? FUC M 942 . ? 1_555 ? 44 AC8 9 BMA J . ? BMA M 944 . ? 1_555 ? 45 AC8 9 XYP K . ? XYP M 945 . ? 1_555 ? 46 AC8 9 HOH GA . ? HOH M 2689 . ? 1_555 ? 47 AC8 9 HOH GA . ? HOH M 2691 . ? 1_555 ? 48 AC8 9 HOH GA . ? HOH M 2692 . ? 1_555 ? 49 AC8 9 HOH GA . ? HOH M 2694 . ? 1_555 ? 50 AC9 2 NAG I . ? NAG M 943 . ? 1_555 ? 51 AC9 2 XYP K . ? XYP M 945 . ? 1_555 ? 52 BC1 6 ASN A 316 ? ASN M 316 . ? 1_555 ? 53 BC1 6 LYS A 319 ? LYS M 319 . ? 1_555 ? 54 BC1 6 NAG I . ? NAG M 943 . ? 1_555 ? 55 BC1 6 BMA J . ? BMA M 944 . ? 1_555 ? 56 BC1 6 HOH GA . ? HOH M 2692 . ? 1_555 ? 57 BC1 6 HOH GA . ? HOH M 2695 . ? 1_555 ? 58 BC2 9 ASN A 292 ? ASN M 292 . ? 1_555 ? 59 BC2 9 THR A 294 ? THR M 294 . ? 1_555 ? 60 BC2 9 FUC M . ? FUC M 952 . ? 1_555 ? 61 BC2 9 NAG N . ? NAG M 953 . ? 1_555 ? 62 BC2 9 HOH GA . ? HOH M 2426 . ? 1_555 ? 63 BC2 9 HOH GA . ? HOH M 2430 . ? 1_555 ? 64 BC2 9 HOH GA . ? HOH M 2696 . ? 1_555 ? 65 BC2 9 HOH GA . ? HOH M 2697 . ? 1_555 ? 66 BC2 9 HOH GA . ? HOH M 2762 . ? 1_555 ? 67 BC3 9 ILE A 129 ? ILE M 129 . ? 1_555 ? 68 BC3 9 GLN A 297 ? GLN M 297 . ? 1_555 ? 69 BC3 9 NAG L . ? NAG M 951 . ? 1_555 ? 70 BC3 9 NAG N . ? NAG M 953 . ? 1_555 ? 71 BC3 9 HOH GA . ? HOH M 2700 . ? 1_555 ? 72 BC3 9 HOH GA . ? HOH M 2701 . ? 1_555 ? 73 BC3 9 HOH GA . ? HOH M 2702 . ? 1_555 ? 74 BC3 9 HOH GA . ? HOH M 2704 . ? 1_555 ? 75 BC3 9 HOH GA . ? HOH M 2762 . ? 1_555 ? 76 BC4 11 GLN A 297 ? GLN M 297 . ? 1_555 ? 77 BC4 11 NAG L . ? NAG M 951 . ? 1_555 ? 78 BC4 11 FUC M . ? FUC M 952 . ? 1_555 ? 79 BC4 11 BMA O . ? BMA M 954 . ? 1_555 ? 80 BC4 11 XYP P . ? XYP M 955 . ? 1_555 ? 81 BC4 11 MAN Q . ? MAN M 956 . ? 1_555 ? 82 BC4 11 HOH GA . ? HOH M 2260 . ? 1_555 ? 83 BC4 11 HOH GA . ? HOH M 2705 . ? 1_555 ? 84 BC4 11 HOH GA . ? HOH M 2706 . ? 1_555 ? 85 BC4 11 HOH GA . ? HOH M 2713 . ? 1_555 ? 86 BC4 11 HOH GA . ? HOH M 2717 . ? 1_555 ? 87 BC5 7 NAG N . ? NAG M 953 . ? 1_555 ? 88 BC5 7 XYP P . ? XYP M 955 . ? 1_555 ? 89 BC5 7 MAN Q . ? MAN M 956 . ? 1_555 ? 90 BC5 7 MAN R . ? MAN M 957 . ? 1_555 ? 91 BC5 7 HOH GA . ? HOH M 2708 . ? 1_555 ? 92 BC5 7 HOH GA . ? HOH M 2711 . ? 1_555 ? 93 BC5 7 HOH GA . ? HOH M 2713 . ? 1_555 ? 94 BC6 5 NAG N . ? NAG M 953 . ? 1_555 ? 95 BC6 5 BMA O . ? BMA M 954 . ? 1_555 ? 96 BC6 5 MAN Q . ? MAN M 956 . ? 1_555 ? 97 BC6 5 HOH GA . ? HOH M 2713 . ? 1_555 ? 98 BC6 5 HOH GA . ? HOH M 2714 . ? 1_555 ? 99 BC7 9 GLN A 297 ? GLN M 297 . ? 1_555 ? 100 BC7 9 ILE A 300 ? ILE M 300 . ? 1_555 ? 101 BC7 9 NAG N . ? NAG M 953 . ? 1_555 ? 102 BC7 9 BMA O . ? BMA M 954 . ? 1_555 ? 103 BC7 9 XYP P . ? XYP M 955 . ? 1_555 ? 104 BC7 9 HOH GA . ? HOH M 2716 . ? 1_555 ? 105 BC7 9 HOH GA . ? HOH M 2717 . ? 1_555 ? 106 BC7 9 HOH GA . ? HOH M 2718 . ? 1_555 ? 107 BC7 9 HOH GA . ? HOH M 2719 . ? 1_555 ? 108 BC8 8 THR A 92 ? THR M 92 . ? 1_555 ? 109 BC8 8 NAG C . ? NAG M 911 . ? 1_555 ? 110 BC8 8 BMA O . ? BMA M 954 . ? 1_555 ? 111 BC8 8 HOH GA . ? HOH M 2711 . ? 1_555 ? 112 BC8 8 HOH GA . ? HOH M 2721 . ? 1_555 ? 113 BC8 8 HOH GA . ? HOH M 2722 . ? 1_555 ? 114 BC8 8 HOH GA . ? HOH M 2723 . ? 1_555 ? 115 BC8 8 HOH GA . ? HOH M 2724 . ? 1_555 ? 116 BC9 5 ASN A 60 ? ASN M 60 . ? 1_555 ? 117 BC9 5 HOH GA . ? HOH M 2111 . ? 1_555 ? 118 BC9 5 HOH GA . ? HOH M 2119 . ? 1_555 ? 119 BC9 5 HOH GA . ? HOH M 2728 . ? 1_555 ? 120 BC9 5 HOH GA . ? HOH M 2729 . ? 1_555 ? 121 CC1 3 ASN A 346 ? ASN M 346 . ? 1_555 ? 122 CC1 3 MET A 351 ? MET M 351 . ? 1_555 ? 123 CC1 3 HOH GA . ? HOH M 2498 . ? 1_555 ? 124 CC2 9 ASN A 265 ? ASN M 265 . ? 1_555 ? 125 CC2 9 ASP A 266 ? ASP M 266 . ? 1_555 ? 126 CC2 9 ASN A 361 ? ASN M 361 . ? 1_555 ? 127 CC2 9 SER A 363 ? SER M 363 . ? 1_555 ? 128 CC2 9 HIS A 365 ? HIS M 365 . ? 1_555 ? 129 CC2 9 NAG V . ? NAG M 983 . ? 1_555 ? 130 CC2 9 HOH GA . ? HOH M 2395 . ? 1_555 ? 131 CC2 9 HOH GA . ? HOH M 2399 . ? 1_555 ? 132 CC2 9 HOH GA . ? HOH M 2478 . ? 1_555 ? 133 CC3 5 PRO A 11 ? PRO M 11 . ? 1_555 ? 134 CC3 5 NAG U . ? NAG M 981 . ? 1_555 ? 135 CC3 5 HOH GA . ? HOH M 2005 . ? 1_555 ? 136 CC3 5 HOH GA . ? HOH M 2735 . ? 1_555 ? 137 CC3 5 HOH GA . ? HOH M 2736 . ? 1_555 ? 138 CC4 4 ASN A 482 ? ASN M 482 . ? 1_555 ? 139 CC4 4 ASP A 485 ? ASP M 485 . ? 1_555 ? 140 CC4 4 HOH GA . ? HOH M 2737 . ? 1_555 ? 141 CC4 4 HOH GA . ? HOH M 2738 . ? 1_555 ? 142 CC5 2 HIS A 56 ? HIS M 56 . ? 1_555 ? 143 CC5 2 ASP A 70 ? ASP M 70 . ? 1_555 ? 144 CC6 6 GLU A 153 ? GLU M 153 . ? 1_555 ? 145 CC6 6 ARG A 205 ? ARG M 205 . ? 1_555 ? 146 CC6 6 HOH GA . ? HOH M 2744 . ? 1_555 ? 147 CC6 6 HOH GA . ? HOH M 2745 . ? 1_555 ? 148 CC6 6 HOH GA . ? HOH M 2746 . ? 1_555 ? 149 CC6 6 HOH GA . ? HOH M 2747 . ? 1_555 ? 150 CC7 6 LYS A 108 ? LYS M 108 . ? 1_555 ? 151 CC7 6 ARG A 111 ? ARG M 111 . ? 1_555 ? 152 CC7 6 HOH GA . ? HOH M 2222 . ? 1_555 ? 153 CC7 6 HOH GA . ? HOH M 2749 . ? 1_555 ? 154 CC7 6 HOH GA . ? HOH M 2750 . ? 1_555 ? 155 CC7 6 HOH GA . ? HOH M 2751 . ? 1_555 ? 156 CC8 5 ARG A 259 ? ARG M 259 . ? 1_555 ? 157 CC8 5 GLN A 333 ? GLN M 333 . ? 1_555 ? 158 CC8 5 LEU A 357 ? LEU M 357 . ? 1_555 ? 159 CC8 5 HOH GA . ? HOH M 2333 . ? 1_555 ? 160 CC8 5 HOH GA . ? HOH M 2752 . ? 1_555 ? 161 CC9 9 GLN A 7 ? GLN M 7 . ? 1_555 ? 162 CC9 9 GLU A 8 ? GLU M 8 . ? 1_555 ? 163 CC9 9 ASN A 9 ? ASN M 9 . ? 1_555 ? 164 CC9 9 HOH GA . ? HOH M 2754 . ? 1_555 ? 165 CC9 9 HOH GA . ? HOH M 2755 . ? 1_555 ? 166 CC9 9 HOH GA . ? HOH M 2756 . ? 1_555 ? 167 CC9 9 HOH GA . ? HOH M 2757 . ? 1_555 ? 168 CC9 9 HOH GA . ? HOH M 2758 . ? 1_555 ? 169 CC9 9 HOH GA . ? HOH M 2759 . ? 1_555 ? 170 DC1 21 GLN A 187 ? GLN M 187 . ? 1_555 ? 171 DC1 21 TYR A 189 ? TYR M 189 . ? 1_555 ? 172 DC1 21 SER A 190 ? SER M 190 . ? 1_555 ? 173 DC1 21 ARG A 194 ? ARG M 194 . ? 1_555 ? 174 DC1 21 ILE A 257 ? ILE M 257 . ? 1_555 ? 175 DC1 21 ARG A 259 ? ARG M 259 . ? 1_555 ? 176 DC1 21 TYR A 330 ? TYR M 330 . ? 1_555 ? 177 DC1 21 PHE A 371 ? PHE M 371 . ? 1_555 ? 178 DC1 21 GLU A 409 ? GLU M 409 . ? 1_555 ? 179 DC1 21 TRP A 457 ? TRP M 457 . ? 1_555 ? 180 DC1 21 GLU A 464 ? GLU M 464 . ? 1_555 ? 181 DC1 21 PHE A 465 ? PHE M 465 . ? 1_555 ? 182 DC1 21 PHE A 473 ? PHE M 473 . ? 1_555 ? 183 DC1 21 GOL Y . ? GOL M 1000 . ? 1_555 ? 184 DC1 21 HOH GA . ? HOH M 2532 . ? 1_555 ? 185 DC1 21 HOH GA . ? HOH M 2636 . ? 1_555 ? 186 DC1 21 HOH GA . ? HOH M 2739 . ? 1_555 ? 187 DC1 21 HOH GA . ? HOH M 2740 . ? 1_555 ? 188 DC1 21 HOH GA . ? HOH M 2741 . ? 1_555 ? 189 DC1 21 HOH GA . ? HOH M 2742 . ? 1_555 ? 190 DC1 21 HOH GA . ? HOH M 2743 . ? 1_555 ? 191 DC2 11 GLN A 39 ? GLN M 39 . ? 1_555 ? 192 DC2 11 HIS A 141 ? HIS M 141 . ? 1_555 ? 193 DC2 11 ASN A 186 ? ASN M 186 . ? 1_555 ? 194 DC2 11 GLN A 187 ? GLN M 187 . ? 1_555 ? 195 DC2 11 GLU A 409 ? GLU M 409 . ? 1_555 ? 196 DC2 11 TRP A 457 ? TRP M 457 . ? 1_555 ? 197 DC2 11 GLU A 464 ? GLU M 464 . ? 1_555 ? 198 DC2 11 PHE A 465 ? PHE M 465 . ? 1_555 ? 199 DC2 11 CGT X . ? CGT M 999 . ? 1_555 ? 200 DC2 11 HOH GA . ? HOH M 2742 . ? 1_555 ? 201 DC2 11 HOH GA . ? HOH M 2743 . ? 1_555 ? 202 DC3 8 PHE A 54 ? PHE M 54 . ? 1_555 ? 203 DC3 8 ARG A 57 ? ARG M 57 . ? 1_555 ? 204 DC3 8 GLN A 146 ? GLN M 146 . ? 1_555 ? 205 DC3 8 GLN A 149 ? GLN M 149 . ? 1_555 ? 206 DC3 8 PRO A 203 ? PRO M 203 . ? 1_555 ? 207 DC3 8 TYR A 215 ? TYR M 215 . ? 1_555 ? 208 DC3 8 HOH GA . ? HOH M 2296 . ? 1_555 ? 209 DC3 8 HOH GA . ? HOH M 2760 . ? 1_555 ? 210 DC4 11 THR A 246 ? THR M 246 . ? 1_555 ? 211 DC4 11 HIS A 247 ? HIS M 247 . ? 1_555 ? 212 DC4 11 GLY A 249 ? GLY M 249 . ? 1_555 ? 213 DC4 11 GLU A 280 ? GLU M 280 . ? 1_555 ? 214 DC4 11 GLN A 297 ? GLN M 297 . ? 1_555 ? 215 DC4 11 ILE A 298 ? ILE M 298 . ? 1_555 ? 216 DC4 11 HOH GA . ? HOH M 2701 . ? 1_555 ? 217 DC4 11 HOH GA . ? HOH M 2761 . ? 1_555 ? 218 DC4 11 HOH GA . ? HOH M 2762 . ? 1_555 ? 219 DC4 11 HOH GA . ? HOH M 2763 . ? 1_555 ? 220 DC4 11 HOH GA . ? HOH M 2764 . ? 1_555 ? # _database_PDB_matrix.entry_id 1W9B _database_PDB_matrix.origx[1][1] 1.000000 _database_PDB_matrix.origx[1][2] 0.000000 _database_PDB_matrix.origx[1][3] 0.000000 _database_PDB_matrix.origx[2][1] 0.000000 _database_PDB_matrix.origx[2][2] 1.000000 _database_PDB_matrix.origx[2][3] 0.000000 _database_PDB_matrix.origx[3][1] 0.000000 _database_PDB_matrix.origx[3][2] 0.000000 _database_PDB_matrix.origx[3][3] 1.000000 _database_PDB_matrix.origx_vector[1] 0.00000 _database_PDB_matrix.origx_vector[2] 0.00000 _database_PDB_matrix.origx_vector[3] 0.00000 # _atom_sites.entry_id 1W9B _atom_sites.fract_transf_matrix[1][1] 0.007391 _atom_sites.fract_transf_matrix[1][2] 0.000000 _atom_sites.fract_transf_matrix[1][3] 0.000000 _atom_sites.fract_transf_matrix[2][1] 0.000000 _atom_sites.fract_transf_matrix[2][2] 0.007289 _atom_sites.fract_transf_matrix[2][3] 0.000000 _atom_sites.fract_transf_matrix[3][1] 0.000000 _atom_sites.fract_transf_matrix[3][2] 0.000000 _atom_sites.fract_transf_matrix[3][3] 0.012407 _atom_sites.fract_transf_vector[1] 0.00000 _atom_sites.fract_transf_vector[2] 0.00000 _atom_sites.fract_transf_vector[3] 0.00000 # loop_ _atom_type.symbol C N O S ZN # loop_ _atom_site.group_PDB _atom_site.id _atom_site.type_symbol _atom_site.label_atom_id _atom_site.label_alt_id _atom_site.label_comp_id _atom_site.label_asym_id _atom_site.label_entity_id _atom_site.label_seq_id _atom_site.pdbx_PDB_ins_code _atom_site.Cartn_x _atom_site.Cartn_y _atom_site.Cartn_z _atom_site.occupancy _atom_site.B_iso_or_equiv _atom_site.pdbx_formal_charge _atom_site.auth_seq_id _atom_site.auth_comp_id _atom_site.auth_asym_id _atom_site.auth_atom_id _atom_site.pdbx_PDB_model_num ATOM 1 N N . GLU A 1 3 ? 14.523 126.765 50.992 1.00 43.29 ? 3 GLU M N 1 ATOM 2 C CA . GLU A 1 3 ? 15.478 126.517 49.874 1.00 43.20 ? 3 GLU M CA 1 ATOM 3 C C . GLU A 1 3 ? 16.740 127.351 50.095 1.00 41.03 ? 3 GLU M C 1 ATOM 4 O O . GLU A 1 3 ? 16.681 128.580 50.169 1.00 40.89 ? 3 GLU M O 1 ATOM 5 C CB . GLU A 1 3 ? 14.823 126.877 48.534 1.00 45.11 ? 3 GLU M CB 1 ATOM 6 C CG . GLU A 1 3 ? 15.400 126.156 47.312 1.00 48.81 ? 3 GLU M CG 1 ATOM 7 C CD . GLU A 1 3 ? 16.795 126.621 46.936 1.00 51.11 ? 3 GLU M CD 1 ATOM 8 O OE1 . GLU A 1 3 ? 16.957 127.812 46.593 1.00 53.47 ? 3 GLU M OE1 1 ATOM 9 O OE2 . GLU A 1 3 ? 17.730 125.792 46.975 1.00 52.58 ? 3 GLU M OE2 1 ATOM 10 N N . ILE A 1 4 ? 17.874 126.667 50.212 1.00 37.94 ? 4 ILE M N 1 ATOM 11 C CA . ILE A 1 4 ? 19.161 127.316 50.436 1.00 34.14 ? 4 ILE M CA 1 ATOM 12 C C . ILE A 1 4 ? 19.848 127.702 49.131 1.00 31.44 ? 4 ILE M C 1 ATOM 13 O O . ILE A 1 4 ? 19.963 126.892 48.215 1.00 31.67 ? 4 ILE M O 1 ATOM 14 C CB . ILE A 1 4 ? 20.112 126.398 51.239 1.00 34.25 ? 4 ILE M CB 1 ATOM 15 C CG1 . ILE A 1 4 ? 19.503 126.078 52.604 1.00 35.00 ? 4 ILE M CG1 1 ATOM 16 C CG2 . ILE A 1 4 ? 21.481 127.051 51.406 1.00 33.47 ? 4 ILE M CG2 1 ATOM 17 C CD1 . ILE A 1 4 ? 20.352 125.159 53.439 1.00 35.36 ? 4 ILE M CD1 1 ATOM 18 N N . THR A 1 5 ? 20.298 128.949 49.056 1.00 28.10 ? 5 THR M N 1 ATOM 19 C CA . THR A 1 5 ? 20.997 129.444 47.878 1.00 25.10 ? 5 THR M CA 1 ATOM 20 C C . THR A 1 5 ? 22.405 129.852 48.298 1.00 21.06 ? 5 THR M C 1 ATOM 21 O O . THR A 1 5 ? 22.577 130.590 49.267 1.00 21.08 ? 5 THR M O 1 ATOM 22 C CB . THR A 1 5 ? 20.278 130.664 47.264 1.00 28.10 ? 5 THR M CB 1 ATOM 23 O OG1 . THR A 1 5 ? 18.944 130.296 46.889 1.00 31.32 ? 5 THR M OG1 1 ATOM 24 C CG2 . THR A 1 5 ? 21.022 131.155 46.029 1.00 29.72 ? 5 THR M CG2 1 ATOM 25 N N . CYS A 1 6 ? 23.405 129.325 47.598 1.00 17.07 ? 6 CYS M N 1 ATOM 26 C CA . CYS A 1 6 ? 24.798 129.645 47.889 1.00 14.50 ? 6 CYS M CA 1 ATOM 27 C C . CYS A 1 6 ? 25.469 130.287 46.688 1.00 13.18 ? 6 CYS M C 1 ATOM 28 O O . CYS A 1 6 ? 25.193 129.930 45.546 1.00 18.28 ? 6 CYS M O 1 ATOM 29 C CB . CYS A 1 6 ? 25.576 128.393 48.287 1.00 15.98 ? 6 CYS M CB 1 ATOM 30 S SG . CYS A 1 6 ? 25.034 127.658 49.858 1.00 17.87 ? 6 CYS M SG 1 ATOM 31 N N . GLN A 1 7 ? 26.373 131.219 46.963 1.00 13.82 ? 7 GLN M N 1 ATOM 32 C CA . GLN A 1 7 ? 27.101 131.929 45.920 1.00 13.39 ? 7 GLN M CA 1 ATOM 33 C C . GLN A 1 7 ? 28.316 131.144 45.439 1.00 12.50 ? 7 GLN M C 1 ATOM 34 O O . GLN A 1 7 ? 28.975 130.462 46.221 1.00 12.23 ? 7 GLN M O 1 ATOM 35 C CB . GLN A 1 7 ? 27.542 133.291 46.449 1.00 15.61 ? 7 GLN M CB 1 ATOM 36 C CG . GLN A 1 7 ? 26.379 134.162 46.896 1.00 17.66 ? 7 GLN M CG 1 ATOM 37 C CD . GLN A 1 7 ? 26.772 135.162 47.961 1.00 16.83 ? 7 GLN M CD 1 ATOM 38 O OE1 . GLN A 1 7 ? 27.608 134.878 48.820 1.00 19.36 ? 7 GLN M OE1 1 ATOM 39 N NE2 . GLN A 1 7 ? 26.147 136.329 47.931 1.00 19.65 ? 7 GLN M NE2 1 ATOM 40 N N . GLU A 1 8 ? 28.612 131.264 44.148 1.00 11.55 ? 8 GLU M N 1 ATOM 41 C CA . GLU A 1 8 ? 29.748 130.578 43.541 1.00 9.20 ? 8 GLU M CA 1 ATOM 42 C C . GLU A 1 8 ? 30.810 131.554 43.064 1.00 11.08 ? 8 GLU M C 1 ATOM 43 O O . GLU A 1 8 ? 31.960 131.169 42.843 1.00 12.27 ? 8 GLU M O 1 ATOM 44 C CB . GLU A 1 8 ? 29.290 129.750 42.342 1.00 11.53 ? 8 GLU M CB 1 ATOM 45 C CG . GLU A 1 8 ? 28.316 128.642 42.680 1.00 12.73 ? 8 GLU M CG 1 ATOM 46 C CD . GLU A 1 8 ? 28.023 127.760 41.488 1.00 18.04 ? 8 GLU M CD 1 ATOM 47 O OE1 . GLU A 1 8 ? 28.949 127.067 41.014 1.00 17.72 ? 8 GLU M OE1 1 ATOM 48 O OE2 . GLU A 1 8 ? 26.868 127.765 41.015 1.00 25.25 ? 8 GLU M OE2 1 ATOM 49 N N . ASN A 1 9 ? 30.423 132.818 42.917 1.00 11.05 ? 9 ASN M N 1 ATOM 50 C CA . ASN A 1 9 ? 31.335 133.846 42.422 1.00 12.38 ? 9 ASN M CA 1 ATOM 51 C C . ASN A 1 9 ? 31.413 135.060 43.335 1.00 10.65 ? 9 ASN M C 1 ATOM 52 O O . ASN A 1 9 ? 30.499 135.322 44.120 1.00 13.32 ? 9 ASN M O 1 ATOM 53 C CB . ASN A 1 9 ? 30.865 134.327 41.045 1.00 14.87 ? 9 ASN M CB 1 ATOM 54 C CG . ASN A 1 9 ? 30.551 133.185 40.099 1.00 14.44 ? 9 ASN M CG 1 ATOM 55 O OD1 . ASN A 1 9 ? 31.450 132.537 39.578 1.00 16.26 ? 9 ASN M OD1 1 ATOM 56 N ND2 . ASN A 1 9 ? 29.263 132.940 39.867 1.00 16.18 ? 9 ASN M ND2 1 ATOM 57 N N . LEU A 1 10 ? 32.510 135.804 43.217 1.00 10.75 ? 10 LEU M N 1 ATOM 58 C CA . LEU A 1 10 ? 32.689 137.024 43.993 1.00 10.72 ? 10 LEU M CA 1 ATOM 59 C C . LEU A 1 10 ? 31.665 138.028 43.465 1.00 12.09 ? 10 LEU M C 1 ATOM 60 O O . LEU A 1 10 ? 31.347 138.024 42.280 1.00 12.97 ? 10 LEU M O 1 ATOM 61 C CB . LEU A 1 10 ? 34.098 137.583 43.795 1.00 13.48 ? 10 LEU M CB 1 ATOM 62 C CG . LEU A 1 10 ? 35.261 136.834 44.450 1.00 14.72 ? 10 LEU M CG 1 ATOM 63 C CD1 . LEU A 1 10 ? 36.583 137.418 43.976 1.00 15.21 ? 10 LEU M CD1 1 ATOM 64 C CD2 . LEU A 1 10 ? 35.148 136.925 45.963 1.00 19.88 ? 10 LEU M CD2 1 ATOM 65 N N . PRO A 1 11 ? 31.123 138.888 44.338 1.00 14.27 ? 11 PRO M N 1 ATOM 66 C CA . PRO A 1 11 ? 31.404 138.958 45.773 1.00 12.75 ? 11 PRO M CA 1 ATOM 67 C C . PRO A 1 11 ? 30.539 137.997 46.576 1.00 13.19 ? 11 PRO M C 1 ATOM 68 O O . PRO A 1 11 ? 29.443 137.623 46.153 1.00 14.03 ? 11 PRO M O 1 ATOM 69 C CB . PRO A 1 11 ? 31.057 140.407 46.100 1.00 16.20 ? 11 PRO M CB 1 ATOM 70 C CG . PRO A 1 11 ? 29.864 140.640 45.240 1.00 16.02 ? 11 PRO M CG 1 ATOM 71 C CD . PRO A 1 11 ? 30.263 140.011 43.919 1.00 15.74 ? 11 PRO M CD 1 ATOM 72 N N . PHE A 1 12 ? 31.048 137.593 47.732 1.00 14.28 ? 12 PHE M N 1 ATOM 73 C CA . PHE A 1 12 ? 30.324 136.689 48.616 1.00 13.39 ? 12 PHE M CA 1 ATOM 74 C C . PHE A 1 12 ? 29.719 137.497 49.752 1.00 15.41 ? 12 PHE M C 1 ATOM 75 O O . PHE A 1 12 ? 30.288 138.504 50.177 1.00 17.22 ? 12 PHE M O 1 ATOM 76 C CB . PHE A 1 12 ? 31.272 135.631 49.187 1.00 13.75 ? 12 PHE M CB 1 ATOM 77 C CG . PHE A 1 12 ? 31.819 134.687 48.158 1.00 14.55 ? 12 PHE M CG 1 ATOM 78 C CD1 . PHE A 1 12 ? 30.976 133.804 47.492 1.00 17.22 ? 12 PHE M CD1 1 ATOM 79 C CD2 . PHE A 1 12 ? 33.168 134.700 47.825 1.00 17.61 ? 12 PHE M CD2 1 ATOM 80 C CE1 . PHE A 1 12 ? 31.473 132.938 46.519 1.00 16.79 ? 12 PHE M CE1 1 ATOM 81 C CE2 . PHE A 1 12 ? 33.674 133.834 46.851 1.00 16.87 ? 12 PHE M CE2 1 ATOM 82 C CZ . PHE A 1 12 ? 32.822 132.959 46.193 1.00 15.50 ? 12 PHE M CZ 1 ATOM 83 N N . THR A 1 13 ? 28.557 137.064 50.229 1.00 14.29 ? 13 THR M N 1 ATOM 84 C CA . THR A 1 13 ? 27.887 137.743 51.332 1.00 16.57 ? 13 THR M CA 1 ATOM 85 C C . THR A 1 13 ? 27.674 136.783 52.497 1.00 17.02 ? 13 THR M C 1 ATOM 86 O O . THR A 1 13 ? 27.006 137.128 53.473 1.00 17.82 ? 13 THR M O 1 ATOM 87 C CB . THR A 1 13 ? 26.522 138.327 50.903 1.00 16.92 ? 13 THR M CB 1 ATOM 88 O OG1 . THR A 1 13 ? 25.678 137.278 50.414 1.00 19.24 ? 13 THR M OG1 1 ATOM 89 C CG2 . THR A 1 13 ? 26.705 139.377 49.814 1.00 20.84 ? 13 THR M CG2 1 ATOM 90 N N . CYS A 1 14 ? 28.270 135.593 52.402 1.00 15.47 ? 14 CYS M N 1 ATOM 91 C CA . CYS A 1 14 ? 28.142 134.579 53.446 1.00 15.52 ? 14 CYS M CA 1 ATOM 92 C C . CYS A 1 14 ? 28.913 134.886 54.721 1.00 15.21 ? 14 CYS M C 1 ATOM 93 O O . CYS A 1 14 ? 28.825 134.137 55.691 1.00 16.47 ? 14 CYS M O 1 ATOM 94 C CB . CYS A 1 14 ? 28.535 133.192 52.925 1.00 15.65 ? 14 CYS M CB 1 ATOM 95 S SG . CYS A 1 14 ? 30.094 133.057 51.982 1.00 17.72 ? 14 CYS M SG 1 ATOM 96 N N . GLY A 1 15 ? 29.684 135.971 54.702 1.00 14.12 ? 15 GLY M N 1 ATOM 97 C CA . GLY A 1 15 ? 30.450 136.371 55.868 1.00 16.49 ? 15 GLY M CA 1 ATOM 98 C C . GLY A 1 15 ? 29.566 137.016 56.921 1.00 16.94 ? 15 GLY M C 1 ATOM 99 O O . GLY A 1 15 ? 30.013 137.299 58.032 1.00 19.40 ? 15 GLY M O 1 ATOM 100 N N . ASN A 1 16 ? 28.312 137.269 56.555 1.00 17.42 ? 16 ASN M N 1 ATOM 101 C CA . ASN A 1 16 ? 27.339 137.870 57.459 1.00 18.53 ? 16 ASN M CA 1 ATOM 102 C C . ASN A 1 16 ? 26.752 136.764 58.331 1.00 16.88 ? 16 ASN M C 1 ATOM 103 O O . ASN A 1 16 ? 25.952 135.952 57.863 1.00 16.99 ? 16 ASN M O 1 ATOM 104 C CB . ASN A 1 16 ? 26.229 138.553 56.654 1.00 21.36 ? 16 ASN M CB 1 ATOM 105 C CG . ASN A 1 16 ? 25.218 139.268 57.533 1.00 23.73 ? 16 ASN M CG 1 ATOM 106 O OD1 . ASN A 1 16 ? 25.306 139.238 58.764 1.00 24.13 ? 16 ASN M OD1 1 ATOM 107 N ND2 . ASN A 1 16 ? 24.250 139.924 56.900 1.00 27.04 ? 16 ASN M ND2 1 ATOM 108 N N . THR A 1 17 ? 27.135 136.752 59.604 1.00 18.81 ? 17 THR M N 1 ATOM 109 C CA . THR A 1 17 ? 26.667 135.730 60.535 1.00 21.18 ? 17 THR M CA 1 ATOM 110 C C . THR A 1 17 ? 25.164 135.730 60.810 1.00 23.25 ? 17 THR M C 1 ATOM 111 O O . THR A 1 17 ? 24.647 134.804 61.433 1.00 23.12 ? 17 THR M O 1 ATOM 112 C CB . THR A 1 17 ? 27.447 135.769 61.863 1.00 21.53 ? 17 THR M CB 1 ATOM 113 O OG1 . THR A 1 17 ? 27.324 137.064 62.459 1.00 22.65 ? 17 THR M OG1 1 ATOM 114 C CG2 . THR A 1 17 ? 28.918 135.461 61.618 1.00 21.20 ? 17 THR M CG2 1 ATOM 115 N N . ASP A 1 18 ? 24.468 136.772 60.361 1.00 25.28 ? 18 ASP M N 1 ATOM 116 C CA . ASP A 1 18 ? 23.020 136.841 60.534 1.00 28.68 ? 18 ASP M CA 1 ATOM 117 C C . ASP A 1 18 ? 22.364 135.923 59.502 1.00 29.16 ? 18 ASP M C 1 ATOM 118 O O . ASP A 1 18 ? 21.249 135.438 59.703 1.00 31.82 ? 18 ASP M O 1 ATOM 119 C CB . ASP A 1 18 ? 22.511 138.275 60.345 1.00 32.20 ? 18 ASP M CB 1 ATOM 120 C CG . ASP A 1 18 ? 23.009 139.223 61.421 1.00 33.09 ? 18 ASP M CG 1 ATOM 121 O OD1 . ASP A 1 18 ? 23.116 138.805 62.593 1.00 36.49 ? 18 ASP M OD1 1 ATOM 122 O OD2 . ASP A 1 18 ? 23.290 140.395 61.091 1.00 37.97 ? 18 ASP M OD2 1 ATOM 123 N N . ALA A 1 19 ? 23.075 135.691 58.401 1.00 27.65 ? 19 ALA M N 1 ATOM 124 C CA . ALA A 1 19 ? 22.595 134.839 57.318 1.00 26.95 ? 19 ALA M CA 1 ATOM 125 C C . ALA A 1 19 ? 23.125 133.410 57.435 1.00 26.08 ? 19 ALA M C 1 ATOM 126 O O . ALA A 1 19 ? 22.385 132.449 57.225 1.00 27.37 ? 19 ALA M O 1 ATOM 127 C CB . ALA A 1 19 ? 22.988 135.434 55.977 1.00 27.11 ? 19 ALA M CB 1 ATOM 128 N N . LEU A 1 20 ? 24.407 133.275 57.767 1.00 22.39 ? 20 LEU M N 1 ATOM 129 C CA . LEU A 1 20 ? 25.029 131.960 57.903 1.00 19.10 ? 20 LEU M CA 1 ATOM 130 C C . LEU A 1 20 ? 25.823 131.841 59.196 1.00 17.39 ? 20 LEU M C 1 ATOM 131 O O . LEU A 1 20 ? 26.730 132.632 59.452 1.00 14.72 ? 20 LEU M O 1 ATOM 132 C CB . LEU A 1 20 ? 25.951 131.676 56.711 1.00 18.73 ? 20 LEU M CB 1 ATOM 133 C CG . LEU A 1 20 ? 26.704 130.341 56.733 1.00 20.03 ? 20 LEU M CG 1 ATOM 134 C CD1 . LEU A 1 20 ? 25.725 129.182 56.611 1.00 19.30 ? 20 LEU M CD1 1 ATOM 135 C CD2 . LEU A 1 20 ? 27.722 130.303 55.603 1.00 20.22 ? 20 LEU M CD2 1 ATOM 136 N N . ASN A 1 21 ? 25.480 130.841 60.002 1.00 16.23 ? 21 ASN M N 1 ATOM 137 C CA . ASN A 1 21 ? 26.167 130.604 61.264 1.00 17.16 ? 21 ASN M CA 1 ATOM 138 C C . ASN A 1 21 ? 26.038 129.139 61.682 1.00 17.20 ? 21 ASN M C 1 ATOM 139 O O . ASN A 1 21 ? 25.425 128.337 60.977 1.00 17.29 ? 21 ASN M O 1 ATOM 140 C CB . ASN A 1 21 ? 25.637 131.547 62.355 1.00 17.37 ? 21 ASN M CB 1 ATOM 141 C CG . ASN A 1 21 ? 24.150 131.391 62.590 1.00 21.45 ? 21 ASN M CG 1 ATOM 142 O OD1 . ASN A 1 21 ? 23.692 130.315 62.956 1.00 19.75 ? 21 ASN M OD1 1 ATOM 143 N ND2 . ASN A 1 21 ? 23.394 132.463 62.377 1.00 23.84 ? 21 ASN M ND2 1 ATOM 144 N N . SER A 1 22 ? 26.615 128.795 62.828 1.00 16.88 ? 22 SER M N 1 ATOM 145 C CA . SER A 1 22 ? 26.579 127.424 63.324 1.00 17.18 ? 22 SER M CA 1 ATOM 146 C C . SER A 1 22 ? 25.175 126.881 63.572 1.00 17.69 ? 22 SER M C 1 ATOM 147 O O . SER A 1 22 ? 24.962 125.676 63.491 1.00 17.10 ? 22 SER M O 1 ATOM 148 C CB . SER A 1 22 ? 27.423 127.290 64.591 1.00 19.12 ? 22 SER M CB 1 ATOM 149 O OG . SER A 1 22 ? 26.931 128.125 65.620 1.00 20.10 ? 22 SER M OG 1 ATOM 150 N N . SER A 1 23 ? 24.224 127.767 63.865 1.00 17.07 ? 23 SER M N 1 ATOM 151 C CA . SER A 1 23 ? 22.843 127.356 64.114 1.00 19.00 ? 23 SER M CA 1 ATOM 152 C C . SER A 1 23 ? 22.174 126.808 62.858 1.00 19.73 ? 23 SER M C 1 ATOM 153 O O . SER A 1 23 ? 21.121 126.172 62.937 1.00 19.85 ? 23 SER M O 1 ATOM 154 C CB . SER A 1 23 ? 22.027 128.519 64.677 1.00 21.26 ? 23 SER M CB 1 ATOM 155 O OG . SER A 1 23 ? 22.571 128.953 65.911 1.00 28.07 ? 23 SER M OG 1 ATOM 156 N N . SER A 1 24 ? 22.783 127.073 61.703 1.00 20.06 ? 24 SER M N 1 ATOM 157 C CA . SER A 1 24 ? 22.274 126.588 60.424 1.00 20.83 ? 24 SER M CA 1 ATOM 158 C C . SER A 1 24 ? 22.487 125.075 60.353 1.00 20.99 ? 24 SER M C 1 ATOM 159 O O . SER A 1 24 ? 21.785 124.370 59.628 1.00 21.84 ? 24 SER M O 1 ATOM 160 C CB . SER A 1 24 ? 23.019 127.263 59.264 1.00 23.18 ? 24 SER M CB 1 ATOM 161 O OG . SER A 1 24 ? 22.990 128.679 59.375 1.00 25.40 ? 24 SER M OG 1 ATOM 162 N N . PHE A 1 25 ? 23.469 124.592 61.112 1.00 17.51 ? 25 PHE M N 1 ATOM 163 C CA . PHE A 1 25 ? 23.811 123.171 61.165 1.00 16.24 ? 25 PHE M CA 1 ATOM 164 C C . PHE A 1 25 ? 23.161 122.494 62.374 1.00 18.74 ? 25 PHE M C 1 ATOM 165 O O . PHE A 1 25 ? 22.609 123.168 63.247 1.00 18.55 ? 25 PHE M O 1 ATOM 166 C CB . PHE A 1 25 ? 25.335 123.005 61.251 1.00 14.14 ? 25 PHE M CB 1 ATOM 167 C CG . PHE A 1 25 ? 26.079 123.525 60.051 1.00 12.22 ? 25 PHE M CG 1 ATOM 168 C CD1 . PHE A 1 25 ? 26.209 124.893 59.832 1.00 12.75 ? 25 PHE M CD1 1 ATOM 169 C CD2 . PHE A 1 25 ? 26.647 122.644 59.135 1.00 12.20 ? 25 PHE M CD2 1 ATOM 170 C CE1 . PHE A 1 25 ? 26.902 125.377 58.724 1.00 12.34 ? 25 PHE M CE1 1 ATOM 171 C CE2 . PHE A 1 25 ? 27.344 123.117 58.021 1.00 12.49 ? 25 PHE M CE2 1 ATOM 172 C CZ . PHE A 1 25 ? 27.467 124.487 57.815 1.00 13.33 ? 25 PHE M CZ 1 ATOM 173 N N . SER A 1 26 ? 23.231 121.163 62.422 1.00 20.86 ? 26 SER M N 1 ATOM 174 C CA . SER A 1 26 ? 22.665 120.396 63.534 1.00 22.83 ? 26 SER M CA 1 ATOM 175 C C . SER A 1 26 ? 23.378 120.768 64.828 1.00 23.44 ? 26 SER M C 1 ATOM 176 O O . SER A 1 26 ? 24.574 121.055 64.824 1.00 21.58 ? 26 SER M O 1 ATOM 177 C CB . SER A 1 26 ? 22.797 118.891 63.282 1.00 25.40 ? 26 SER M CB 1 ATOM 178 O OG . SER A 1 26 ? 22.069 118.495 62.132 1.00 31.50 ? 26 SER M OG 1 ATOM 179 N N . SER A 1 27 ? 22.640 120.748 65.934 1.00 23.43 ? 27 SER M N 1 ATOM 180 C CA . SER A 1 27 ? 23.172 121.112 67.247 1.00 24.67 ? 27 SER M CA 1 ATOM 181 C C . SER A 1 27 ? 24.487 120.450 67.661 1.00 24.44 ? 27 SER M C 1 ATOM 182 O O . SER A 1 27 ? 25.303 121.067 68.347 1.00 27.03 ? 27 SER M O 1 ATOM 183 C CB . SER A 1 27 ? 22.118 120.861 68.331 1.00 26.52 ? 27 SER M CB 1 ATOM 184 O OG . SER A 1 27 ? 21.807 119.481 68.427 1.00 31.17 ? 27 SER M OG 1 ATOM 185 N N . ASP A 1 28 ? 24.693 119.204 67.251 1.00 22.95 ? 28 ASP M N 1 ATOM 186 C CA . ASP A 1 28 ? 25.909 118.486 67.619 1.00 23.99 ? 28 ASP M CA 1 ATOM 187 C C . ASP A 1 28 ? 27.056 118.596 66.616 1.00 20.25 ? 28 ASP M C 1 ATOM 188 O O . ASP A 1 28 ? 28.117 118.004 66.824 1.00 20.23 ? 28 ASP M O 1 ATOM 189 C CB . ASP A 1 28 ? 25.595 117.010 67.903 1.00 26.57 ? 28 ASP M CB 1 ATOM 190 C CG . ASP A 1 28 ? 25.159 116.238 66.660 1.00 32.40 ? 28 ASP M CG 1 ATOM 191 O OD1 . ASP A 1 28 ? 24.547 116.832 65.742 1.00 34.63 ? 28 ASP M OD1 1 ATOM 192 O OD2 . ASP A 1 28 ? 25.425 115.016 66.611 1.00 36.67 ? 28 ASP M OD2 1 ATOM 193 N N . PHE A 1 29 ? 26.856 119.374 65.555 1.00 15.51 ? 29 PHE M N 1 ATOM 194 C CA . PHE A 1 29 ? 27.874 119.542 64.516 1.00 12.94 ? 29 PHE M CA 1 ATOM 195 C C . PHE A 1 29 ? 29.143 120.145 65.102 1.00 12.14 ? 29 PHE M C 1 ATOM 196 O O . PHE A 1 29 ? 29.097 121.153 65.803 1.00 14.25 ? 29 PHE M O 1 ATOM 197 C CB . PHE A 1 29 ? 27.339 120.430 63.388 1.00 12.74 ? 29 PHE M CB 1 ATOM 198 C CG . PHE A 1 29 ? 28.091 120.285 62.090 1.00 11.81 ? 29 PHE M CG 1 ATOM 199 C CD1 . PHE A 1 29 ? 29.191 121.086 61.812 1.00 11.80 ? 29 PHE M CD1 1 ATOM 200 C CD2 . PHE A 1 29 ? 27.673 119.368 61.129 1.00 11.57 ? 29 PHE M CD2 1 ATOM 201 C CE1 . PHE A 1 29 ? 29.876 120.971 60.601 1.00 11.38 ? 29 PHE M CE1 1 ATOM 202 C CE2 . PHE A 1 29 ? 28.350 119.244 59.915 1.00 11.30 ? 29 PHE M CE2 1 ATOM 203 C CZ . PHE A 1 29 ? 29.451 120.053 59.648 1.00 10.94 ? 29 PHE M CZ 1 ATOM 204 N N . ILE A 1 30 ? 30.277 119.510 64.819 1.00 10.01 ? 30 ILE M N 1 ATOM 205 C CA . ILE A 1 30 ? 31.558 119.973 65.335 1.00 9.63 ? 30 ILE M CA 1 ATOM 206 C C . ILE A 1 30 ? 32.224 120.998 64.423 1.00 8.65 ? 30 ILE M C 1 ATOM 207 O O . ILE A 1 30 ? 32.249 120.834 63.206 1.00 10.14 ? 30 ILE M O 1 ATOM 208 C CB . ILE A 1 30 ? 32.516 118.781 65.566 1.00 11.40 ? 30 ILE M CB 1 ATOM 209 C CG1 . ILE A 1 30 ? 31.999 117.922 66.722 1.00 15.10 ? 30 ILE M CG1 1 ATOM 210 C CG2 . ILE A 1 30 ? 33.939 119.268 65.834 1.00 13.26 ? 30 ILE M CG2 1 ATOM 211 C CD1 . ILE A 1 30 ? 32.750 116.626 66.905 1.00 18.59 ? 30 ILE M CD1 1 ATOM 212 N N . PHE A 1 31 ? 32.707 122.081 65.026 1.00 9.40 ? 31 PHE M N 1 ATOM 213 C CA . PHE A 1 31 ? 33.406 123.133 64.298 1.00 9.63 ? 31 PHE M CA 1 ATOM 214 C C . PHE A 1 31 ? 34.758 123.352 64.948 1.00 10.16 ? 31 PHE M C 1 ATOM 215 O O . PHE A 1 31 ? 34.863 123.457 66.171 1.00 10.90 ? 31 PHE M O 1 ATOM 216 C CB . PHE A 1 31 ? 32.617 124.442 64.309 1.00 11.86 ? 31 PHE M CB 1 ATOM 217 C CG . PHE A 1 31 ? 31.453 124.449 63.372 1.00 10.40 ? 31 PHE M CG 1 ATOM 218 C CD1 . PHE A 1 31 ? 31.657 124.494 61.996 1.00 11.09 ? 31 PHE M CD1 1 ATOM 219 C CD2 . PHE A 1 31 ? 30.150 124.386 63.859 1.00 12.63 ? 31 PHE M CD2 1 ATOM 220 C CE1 . PHE A 1 31 ? 30.580 124.484 61.116 1.00 10.88 ? 31 PHE M CE1 1 ATOM 221 C CE2 . PHE A 1 31 ? 29.067 124.376 62.988 1.00 12.77 ? 31 PHE M CE2 1 ATOM 222 C CZ . PHE A 1 31 ? 29.283 124.421 61.614 1.00 11.04 ? 31 PHE M CZ 1 ATOM 223 N N . GLY A 1 32 ? 35.799 123.398 64.127 1.00 10.30 ? 32 GLY M N 1 ATOM 224 C CA . GLY A 1 32 ? 37.122 123.610 64.673 1.00 7.77 ? 32 GLY M CA 1 ATOM 225 C C . GLY A 1 32 ? 38.138 123.922 63.607 1.00 7.46 ? 32 GLY M C 1 ATOM 226 O O . GLY A 1 32 ? 37.797 124.398 62.523 1.00 8.16 ? 32 GLY M O 1 ATOM 227 N N . VAL A 1 33 ? 39.399 123.662 63.932 1.00 8.42 ? 33 VAL M N 1 ATOM 228 C CA . VAL A 1 33 ? 40.504 123.900 63.017 1.00 9.11 ? 33 VAL M CA 1 ATOM 229 C C . VAL A 1 33 ? 41.433 122.696 63.041 1.00 7.66 ? 33 VAL M C 1 ATOM 230 O O . VAL A 1 33 ? 41.294 121.809 63.890 1.00 7.76 ? 33 VAL M O 1 ATOM 231 C CB . VAL A 1 33 ? 41.285 125.185 63.377 1.00 9.49 ? 33 VAL M CB 1 ATOM 232 C CG1 . VAL A 1 33 ? 40.450 126.428 63.049 1.00 10.56 ? 33 VAL M CG1 1 ATOM 233 C CG2 . VAL A 1 33 ? 41.650 125.176 64.850 1.00 13.11 ? 33 VAL M CG2 1 ATOM 234 N N . ALA A 1 34 ? 42.394 122.681 62.126 1.00 7.42 ? 34 ALA M N 1 ATOM 235 C CA . ALA A 1 34 ? 43.323 121.562 62.013 1.00 7.12 ? 34 ALA M CA 1 ATOM 236 C C . ALA A 1 34 ? 44.774 122.012 61.914 1.00 6.64 ? 34 ALA M C 1 ATOM 237 O O . ALA A 1 34 ? 45.054 123.167 61.604 1.00 7.95 ? 34 ALA M O 1 ATOM 238 C CB . ALA A 1 34 ? 42.963 120.725 60.788 1.00 6.55 ? 34 ALA M CB 1 ATOM 239 N N . SER A 1 35 ? 45.685 121.073 62.163 1.00 6.82 ? 35 SER M N 1 ATOM 240 C CA . SER A 1 35 ? 47.126 121.316 62.097 1.00 6.04 ? 35 SER M CA 1 ATOM 241 C C . SER A 1 35 ? 47.828 119.973 61.917 1.00 5.71 ? 35 SER M C 1 ATOM 242 O O . SER A 1 35 ? 47.174 118.930 61.914 1.00 6.48 ? 35 SER M O 1 ATOM 243 C CB . SER A 1 35 ? 47.619 121.948 63.401 1.00 7.02 ? 35 SER M CB 1 ATOM 244 O OG . SER A 1 35 ? 47.589 120.998 64.461 1.00 8.75 ? 35 SER M OG 1 ATOM 245 N N . SER A 1 36 ? 49.149 120.005 61.739 1.00 6.26 ? 36 SER M N 1 ATOM 246 C CA . SER A 1 36 ? 49.942 118.777 61.633 1.00 5.28 ? 36 SER M CA 1 ATOM 247 C C . SER A 1 36 ? 51.256 118.971 62.393 1.00 5.23 ? 36 SER M C 1 ATOM 248 O O . SER A 1 36 ? 51.773 120.086 62.478 1.00 6.44 ? 36 SER M O 1 ATOM 249 C CB . SER A 1 36 ? 50.190 118.363 60.179 1.00 8.04 ? 36 SER M CB 1 ATOM 250 O OG . SER A 1 36 ? 51.392 118.898 59.658 1.00 8.31 ? 36 SER M OG 1 ATOM 251 N N . ALA A 1 37 ? 51.789 117.875 62.928 1.00 5.63 ? 37 ALA M N 1 ATOM 252 C CA . ALA A 1 37 ? 53.004 117.904 63.743 1.00 6.38 ? 37 ALA M CA 1 ATOM 253 C C . ALA A 1 37 ? 54.241 118.524 63.117 1.00 5.84 ? 37 ALA M C 1 ATOM 254 O O . ALA A 1 37 ? 54.873 119.388 63.725 1.00 6.01 ? 37 ALA M O 1 ATOM 255 C CB . ALA A 1 37 ? 53.326 116.508 64.258 1.00 7.60 ? 37 ALA M CB 1 ATOM 256 N N . TYR A 1 38 ? 54.608 118.080 61.920 1.00 6.13 ? 38 TYR M N 1 ATOM 257 C CA . TYR A 1 38 ? 55.797 118.634 61.288 1.00 5.95 ? 38 TYR M CA 1 ATOM 258 C C . TYR A 1 38 ? 55.680 120.137 61.078 1.00 6.83 ? 38 TYR M C 1 ATOM 259 O O . TYR A 1 38 ? 56.645 120.885 61.258 1.00 7.15 ? 38 TYR M O 1 ATOM 260 C CB . TYR A 1 38 ? 56.084 117.972 59.936 1.00 5.99 ? 38 TYR M CB 1 ATOM 261 C CG . TYR A 1 38 ? 57.379 118.468 59.346 1.00 4.69 ? 38 TYR M CG 1 ATOM 262 C CD1 . TYR A 1 38 ? 58.603 118.100 59.911 1.00 5.60 ? 38 TYR M CD1 1 ATOM 263 C CD2 . TYR A 1 38 ? 57.385 119.393 58.303 1.00 6.03 ? 38 TYR M CD2 1 ATOM 264 C CE1 . TYR A 1 38 ? 59.798 118.650 59.459 1.00 7.45 ? 38 TYR M CE1 1 ATOM 265 C CE2 . TYR A 1 38 ? 58.578 119.949 57.843 1.00 7.96 ? 38 TYR M CE2 1 ATOM 266 C CZ . TYR A 1 38 ? 59.778 119.575 58.432 1.00 7.22 ? 38 TYR M CZ 1 ATOM 267 O OH . TYR A 1 38 ? 60.959 120.140 58.013 1.00 7.33 ? 38 TYR M OH 1 ATOM 268 N N . GLN A 1 39 ? 54.475 120.572 60.734 1.00 6.36 ? 39 GLN M N 1 ATOM 269 C CA . GLN A 1 39 ? 54.223 121.971 60.456 1.00 6.73 ? 39 GLN M CA 1 ATOM 270 C C . GLN A 1 39 ? 54.195 122.914 61.640 1.00 9.06 ? 39 GLN M C 1 ATOM 271 O O . GLN A 1 39 ? 54.525 124.085 61.479 1.00 9.81 ? 39 GLN M O 1 ATOM 272 C CB . GLN A 1 39 ? 52.931 122.110 59.656 1.00 6.12 ? 39 GLN M CB 1 ATOM 273 C CG . GLN A 1 39 ? 52.980 121.360 58.339 1.00 8.32 ? 39 GLN M CG 1 ATOM 274 C CD . GLN A 1 39 ? 51.676 121.438 57.583 1.00 10.12 ? 39 GLN M CD 1 ATOM 275 O OE1 . GLN A 1 39 ? 50.783 120.620 57.785 1.00 9.69 ? 39 GLN M OE1 1 ATOM 276 N NE2 . GLN A 1 39 ? 51.562 122.418 56.695 1.00 12.00 ? 39 GLN M NE2 1 ATOM 277 N N . ILE A 1 40 ? 53.883 122.408 62.832 1.00 8.02 ? 40 ILE M N 1 ATOM 278 C CA . ILE A 1 40 ? 53.784 123.293 63.991 1.00 7.55 ? 40 ILE M CA 1 ATOM 279 C C . ILE A 1 40 ? 54.676 123.069 65.211 1.00 6.20 ? 40 ILE M C 1 ATOM 280 O O . ILE A 1 40 ? 54.947 124.015 65.948 1.00 8.07 ? 40 ILE M O 1 ATOM 281 C CB . ILE A 1 40 ? 52.320 123.354 64.517 1.00 6.90 ? 40 ILE M CB 1 ATOM 282 C CG1 . ILE A 1 40 ? 51.927 122.022 65.178 1.00 8.09 ? 40 ILE M CG1 1 ATOM 283 C CG2 . ILE A 1 40 ? 51.358 123.688 63.382 1.00 9.48 ? 40 ILE M CG2 1 ATOM 284 C CD1 . ILE A 1 40 ? 50.579 122.051 65.885 1.00 7.41 ? 40 ILE M CD1 1 ATOM 285 N N . GLU A 1 41 ? 55.161 121.851 65.421 1.00 7.67 ? 41 GLU M N 1 ATOM 286 C CA . GLU A 1 41 ? 55.934 121.567 66.631 1.00 6.28 ? 41 GLU M CA 1 ATOM 287 C C . GLU A 1 41 ? 57.371 122.036 66.765 1.00 7.01 ? 41 GLU M C 1 ATOM 288 O O . GLU A 1 41 ? 57.746 122.633 67.779 1.00 8.84 ? 41 GLU M O 1 ATOM 289 C CB . GLU A 1 41 ? 55.913 120.071 66.926 1.00 8.37 ? 41 GLU M CB 1 ATOM 290 C CG . GLU A 1 41 ? 54.532 119.480 67.123 1.00 8.19 ? 41 GLU M CG 1 ATOM 291 C CD . GLU A 1 41 ? 54.578 117.995 67.411 1.00 8.99 ? 41 GLU M CD 1 ATOM 292 O OE1 . GLU A 1 41 ? 55.666 117.388 67.304 1.00 8.83 ? 41 GLU M OE1 1 ATOM 293 O OE2 . GLU A 1 41 ? 53.514 117.430 67.728 1.00 7.73 ? 41 GLU M OE2 1 ATOM 294 N N . GLY A 1 42 ? 58.173 121.721 65.756 1.00 8.96 ? 42 GLY M N 1 ATOM 295 C CA . GLY A 1 42 ? 59.589 122.023 65.798 1.00 8.31 ? 42 GLY M CA 1 ATOM 296 C C . GLY A 1 42 ? 60.272 120.690 66.077 1.00 10.23 ? 42 GLY M C 1 ATOM 297 O O . GLY A 1 42 ? 59.624 119.732 66.524 1.00 11.43 ? 42 GLY M O 1 ATOM 298 N N . THR A 1 43 ? 61.576 120.618 65.833 1.00 7.67 ? 43 THR M N 1 ATOM 299 C CA . THR A 1 43 ? 62.330 119.383 66.038 1.00 8.49 ? 43 THR M CA 1 ATOM 300 C C . THR A 1 43 ? 62.718 119.116 67.490 1.00 6.83 ? 43 THR M C 1 ATOM 301 O O . THR A 1 43 ? 63.130 118.008 67.831 1.00 7.25 ? 43 THR M O 1 ATOM 302 C CB . THR A 1 43 ? 63.623 119.390 65.214 1.00 9.92 ? 43 THR M CB 1 ATOM 303 O OG1 . THR A 1 43 ? 64.389 120.546 65.564 1.00 11.25 ? 43 THR M OG1 1 ATOM 304 C CG2 . THR A 1 43 ? 63.314 119.422 63.728 1.00 10.42 ? 43 THR M CG2 1 ATOM 305 N N . ILE A 1 44 ? 62.626 120.137 68.335 1.00 7.25 ? 44 ILE M N 1 ATOM 306 C CA . ILE A 1 44 ? 62.984 119.975 69.737 1.00 8.34 ? 44 ILE M CA 1 ATOM 307 C C . ILE A 1 44 ? 62.218 118.826 70.388 1.00 7.89 ? 44 ILE M C 1 ATOM 308 O O . ILE A 1 44 ? 61.004 118.695 70.205 1.00 9.16 ? 44 ILE M O 1 ATOM 309 C CB . ILE A 1 44 ? 62.763 121.290 70.533 1.00 11.25 ? 44 ILE M CB 1 ATOM 310 C CG1 . ILE A 1 44 ? 63.096 121.083 72.012 1.00 12.58 ? 44 ILE M CG1 1 ATOM 311 C CG2 . ILE A 1 44 ? 61.343 121.799 70.338 1.00 15.19 ? 44 ILE M CG2 1 ATOM 312 C CD1 . ILE A 1 44 ? 63.114 122.373 72.824 1.00 15.91 ? 44 ILE M CD1 1 ATOM 313 N N . GLY A 1 45 ? 62.958 117.943 71.053 1.00 6.90 ? 45 GLY M N 1 ATOM 314 C CA . GLY A 1 45 ? 62.351 116.824 71.749 1.00 7.00 ? 45 GLY M CA 1 ATOM 315 C C . GLY A 1 45 ? 61.938 115.621 70.926 1.00 8.73 ? 45 GLY M C 1 ATOM 316 O O . GLY A 1 45 ? 61.307 114.708 71.457 1.00 8.99 ? 45 GLY M O 1 ATOM 317 N N . ARG A 1 46 ? 62.278 115.604 69.642 1.00 6.99 ? 46 ARG M N 1 ATOM 318 C CA . ARG A 1 46 ? 61.917 114.462 68.814 1.00 7.03 ? 46 ARG M CA 1 ATOM 319 C C . ARG A 1 46 ? 63.046 113.993 67.915 1.00 7.61 ? 46 ARG M C 1 ATOM 320 O O . ARG A 1 46 ? 64.053 114.685 67.737 1.00 7.48 ? 46 ARG M O 1 ATOM 321 C CB . ARG A 1 46 ? 60.678 114.768 67.960 1.00 6.81 ? 46 ARG M CB 1 ATOM 322 C CG . ARG A 1 46 ? 60.858 115.856 66.907 1.00 7.12 ? 46 ARG M CG 1 ATOM 323 C CD . ARG A 1 46 ? 59.726 115.749 65.898 1.00 8.04 ? 46 ARG M CD 1 ATOM 324 N NE . ARG A 1 46 ? 59.701 116.829 64.915 1.00 6.81 ? 46 ARG M NE 1 ATOM 325 C CZ . ARG A 1 46 ? 60.495 116.892 63.853 1.00 7.28 ? 46 ARG M CZ 1 ATOM 326 N NH1 . ARG A 1 46 ? 61.403 115.946 63.638 1.00 7.32 ? 46 ARG M NH1 1 ATOM 327 N NH2 . ARG A 1 46 ? 60.315 117.849 62.953 1.00 6.88 ? 46 ARG M NH2 1 ATOM 328 N N . GLY A 1 47 ? 62.876 112.788 67.383 1.00 6.74 ? 47 GLY M N 1 ATOM 329 C CA . GLY A 1 47 ? 63.845 112.235 66.461 1.00 7.59 ? 47 GLY M CA 1 ATOM 330 C C . GLY A 1 47 ? 63.623 112.874 65.099 1.00 8.35 ? 47 GLY M C 1 ATOM 331 O O . GLY A 1 47 ? 62.718 113.696 64.924 1.00 9.49 ? 47 GLY M O 1 ATOM 332 N N . LEU A 1 48 ? 64.438 112.485 64.129 1.00 8.29 ? 48 LEU M N 1 ATOM 333 C CA . LEU A 1 48 ? 64.342 113.026 62.779 1.00 7.84 ? 48 LEU M CA 1 ATOM 334 C C . LEU A 1 48 ? 63.447 112.176 61.898 1.00 7.10 ? 48 LEU M C 1 ATOM 335 O O . LEU A 1 48 ? 63.472 110.947 61.974 1.00 8.41 ? 48 LEU M O 1 ATOM 336 C CB . LEU A 1 48 ? 65.730 113.096 62.141 1.00 9.68 ? 48 LEU M CB 1 ATOM 337 C CG . LEU A 1 48 ? 66.768 113.972 62.840 1.00 12.67 ? 48 LEU M CG 1 ATOM 338 C CD1 . LEU A 1 48 ? 68.135 113.731 62.201 1.00 14.67 ? 48 LEU M CD1 1 ATOM 339 C CD2 . LEU A 1 48 ? 66.362 115.433 62.748 1.00 14.07 ? 48 LEU M CD2 1 ATOM 340 N N . ASN A 1 49 ? 62.669 112.843 61.051 1.00 7.26 ? 49 ASN M N 1 ATOM 341 C CA . ASN A 1 49 ? 61.772 112.154 60.127 1.00 7.49 ? 49 ASN M CA 1 ATOM 342 C C . ASN A 1 49 ? 62.107 112.528 58.687 1.00 6.96 ? 49 ASN M C 1 ATOM 343 O O . ASN A 1 49 ? 62.975 113.373 58.447 1.00 7.14 ? 49 ASN M O 1 ATOM 344 C CB . ASN A 1 49 ? 60.306 112.453 60.456 1.00 6.41 ? 49 ASN M CB 1 ATOM 345 C CG . ASN A 1 49 ? 59.990 113.931 60.447 1.00 7.35 ? 49 ASN M CG 1 ATOM 346 O OD1 . ASN A 1 49 ? 60.197 114.616 59.448 1.00 7.58 ? 49 ASN M OD1 1 ATOM 347 N ND2 . ASN A 1 49 ? 59.455 114.427 61.558 1.00 9.11 ? 49 ASN M ND2 1 ATOM 348 N N . ILE A 1 50 ? 61.413 111.919 57.729 1.00 6.07 ? 50 ILE M N 1 ATOM 349 C CA . ILE A 1 50 ? 61.708 112.189 56.326 1.00 6.50 ? 50 ILE M CA 1 ATOM 350 C C . ILE A 1 50 ? 61.443 113.607 55.857 1.00 6.64 ? 50 ILE M C 1 ATOM 351 O O . ILE A 1 50 ? 61.950 114.008 54.817 1.00 6.90 ? 50 ILE M O 1 ATOM 352 C CB . ILE A 1 50 ? 61.037 111.182 55.373 1.00 5.93 ? 50 ILE M CB 1 ATOM 353 C CG1 . ILE A 1 50 ? 59.515 111.285 55.455 1.00 7.85 ? 50 ILE M CG1 1 ATOM 354 C CG2 . ILE A 1 50 ? 61.505 109.776 55.708 1.00 7.77 ? 50 ILE M CG2 1 ATOM 355 C CD1 . ILE A 1 50 ? 58.796 110.412 54.413 1.00 9.64 ? 50 ILE M CD1 1 ATOM 356 N N . TRP A 1 51 ? 60.624 114.360 56.584 1.00 6.22 ? 51 TRP M N 1 ATOM 357 C CA . TRP A 1 51 ? 60.415 115.733 56.179 1.00 7.41 ? 51 TRP M CA 1 ATOM 358 C C . TRP A 1 51 ? 61.615 116.566 56.608 1.00 6.34 ? 51 TRP M C 1 ATOM 359 O O . TRP A 1 51 ? 62.009 117.488 55.902 1.00 7.21 ? 51 TRP M O 1 ATOM 360 C CB . TRP A 1 51 ? 59.066 116.274 56.635 1.00 7.19 ? 51 TRP M CB 1 ATOM 361 C CG . TRP A 1 51 ? 58.066 116.083 55.538 1.00 5.77 ? 51 TRP M CG 1 ATOM 362 C CD1 . TRP A 1 51 ? 57.176 115.053 55.395 1.00 6.67 ? 51 TRP M CD1 1 ATOM 363 C CD2 . TRP A 1 51 ? 57.928 116.898 54.374 1.00 6.09 ? 51 TRP M CD2 1 ATOM 364 N NE1 . TRP A 1 51 ? 56.500 115.175 54.200 1.00 6.81 ? 51 TRP M NE1 1 ATOM 365 C CE2 . TRP A 1 51 ? 56.945 116.304 53.554 1.00 6.88 ? 51 TRP M CE2 1 ATOM 366 C CE3 . TRP A 1 51 ? 58.549 118.079 53.934 1.00 6.53 ? 51 TRP M CE3 1 ATOM 367 C CZ2 . TRP A 1 51 ? 56.562 116.847 52.323 1.00 7.05 ? 51 TRP M CZ2 1 ATOM 368 C CZ3 . TRP A 1 51 ? 58.170 118.623 52.706 1.00 6.14 ? 51 TRP M CZ3 1 ATOM 369 C CH2 . TRP A 1 51 ? 57.186 118.003 51.915 1.00 8.08 ? 51 TRP M CH2 1 ATOM 370 N N . ASP A 1 52 ? 62.236 116.199 57.730 1.00 7.33 ? 52 ASP M N 1 ATOM 371 C CA . ASP A 1 52 ? 63.458 116.876 58.162 1.00 6.54 ? 52 ASP M CA 1 ATOM 372 C C . ASP A 1 52 ? 64.506 116.515 57.097 1.00 7.69 ? 52 ASP M C 1 ATOM 373 O O . ASP A 1 52 ? 65.221 117.377 56.585 1.00 7.52 ? 52 ASP M O 1 ATOM 374 C CB . ASP A 1 52 ? 63.967 116.317 59.500 1.00 7.72 ? 52 ASP M CB 1 ATOM 375 C CG . ASP A 1 52 ? 63.003 116.534 60.648 1.00 7.95 ? 52 ASP M CG 1 ATOM 376 O OD1 . ASP A 1 52 ? 62.551 117.673 60.867 1.00 9.10 ? 52 ASP M OD1 1 ATOM 377 O OD2 . ASP A 1 52 ? 62.727 115.554 61.364 1.00 9.31 ? 52 ASP M OD2 1 ATOM 378 N N . GLY A 1 53 ? 64.578 115.226 56.769 1.00 6.00 ? 53 GLY M N 1 ATOM 379 C CA . GLY A 1 53 ? 65.544 114.750 55.792 1.00 4.99 ? 53 GLY M CA 1 ATOM 380 C C . GLY A 1 53 ? 65.400 115.384 54.425 1.00 6.46 ? 53 GLY M C 1 ATOM 381 O O . GLY A 1 53 ? 66.378 115.837 53.829 1.00 7.44 ? 53 GLY M O 1 ATOM 382 N N . PHE A 1 54 ? 64.166 115.421 53.938 1.00 6.78 ? 54 PHE M N 1 ATOM 383 C CA . PHE A 1 54 ? 63.853 115.981 52.628 1.00 7.50 ? 54 PHE M CA 1 ATOM 384 C C . PHE A 1 54 ? 64.144 117.476 52.543 1.00 7.02 ? 54 PHE M C 1 ATOM 385 O O . PHE A 1 54 ? 64.815 117.933 51.614 1.00 7.23 ? 54 PHE M O 1 ATOM 386 C CB . PHE A 1 54 ? 62.386 115.697 52.315 1.00 7.88 ? 54 PHE M CB 1 ATOM 387 C CG . PHE A 1 54 ? 61.930 116.208 50.985 1.00 7.36 ? 54 PHE M CG 1 ATOM 388 C CD1 . PHE A 1 54 ? 62.311 115.567 49.809 1.00 7.16 ? 54 PHE M CD1 1 ATOM 389 C CD2 . PHE A 1 54 ? 61.069 117.298 50.908 1.00 8.66 ? 54 PHE M CD2 1 ATOM 390 C CE1 . PHE A 1 54 ? 61.840 116.006 48.577 1.00 9.01 ? 54 PHE M CE1 1 ATOM 391 C CE2 . PHE A 1 54 ? 60.590 117.746 49.677 1.00 9.56 ? 54 PHE M CE2 1 ATOM 392 C CZ . PHE A 1 54 ? 60.975 117.096 48.511 1.00 7.97 ? 54 PHE M CZ 1 ATOM 393 N N . THR A 1 55 ? 63.662 118.237 53.520 1.00 6.07 ? 55 THR M N 1 ATOM 394 C CA . THR A 1 55 ? 63.869 119.682 53.513 1.00 7.09 ? 55 THR M CA 1 ATOM 395 C C . THR A 1 55 ? 65.334 120.073 53.654 1.00 8.26 ? 55 THR M C 1 ATOM 396 O O . THR A 1 55 ? 65.750 121.127 53.174 1.00 7.42 ? 55 THR M O 1 ATOM 397 C CB . THR A 1 55 ? 63.059 120.387 54.615 1.00 7.18 ? 55 THR M CB 1 ATOM 398 O OG1 . THR A 1 55 ? 63.434 119.877 55.900 1.00 7.32 ? 55 THR M OG1 1 ATOM 399 C CG2 . THR A 1 55 ? 61.561 120.186 54.394 1.00 7.52 ? 55 THR M CG2 1 ATOM 400 N N . HIS A 1 56 ? 66.112 119.223 54.313 1.00 7.51 ? 56 HIS M N 1 ATOM 401 C CA . HIS A 1 56 ? 67.531 119.499 54.516 1.00 6.72 ? 56 HIS M CA 1 ATOM 402 C C . HIS A 1 56 ? 68.422 119.043 53.373 1.00 6.46 ? 56 HIS M C 1 ATOM 403 O O . HIS A 1 56 ? 69.417 119.696 53.064 1.00 8.21 ? 56 HIS M O 1 ATOM 404 C CB . HIS A 1 56 ? 67.998 118.902 55.842 1.00 5.82 ? 56 HIS M CB 1 ATOM 405 C CG . HIS A 1 56 ? 67.500 119.661 57.030 1.00 8.46 ? 56 HIS M CG 1 ATOM 406 N ND1 . HIS A 1 56 ? 66.158 119.866 57.263 1.00 7.90 ? 56 HIS M ND1 1 ATOM 407 C CD2 . HIS A 1 56 ? 68.160 120.310 58.014 1.00 9.16 ? 56 HIS M CD2 1 ATOM 408 C CE1 . HIS A 1 56 ? 66.011 120.613 58.342 1.00 8.46 ? 56 HIS M CE1 1 ATOM 409 N NE2 . HIS A 1 56 ? 67.208 120.895 58.817 1.00 6.55 ? 56 HIS M NE2 1 ATOM 410 N N . ARG A 1 57 ? 68.064 117.931 52.740 1.00 6.71 ? 57 ARG M N 1 ATOM 411 C CA . ARG A 1 57 ? 68.849 117.426 51.619 1.00 7.06 ? 57 ARG M CA 1 ATOM 412 C C . ARG A 1 57 ? 68.513 118.186 50.334 1.00 7.79 ? 57 ARG M C 1 ATOM 413 O O . ARG A 1 57 ? 69.381 118.416 49.488 1.00 7.84 ? 57 ARG M O 1 ATOM 414 C CB . ARG A 1 57 ? 68.588 115.936 51.421 1.00 7.52 ? 57 ARG M CB 1 ATOM 415 C CG . ARG A 1 57 ? 69.446 115.307 50.339 1.00 8.32 ? 57 ARG M CG 1 ATOM 416 C CD . ARG A 1 57 ? 69.274 113.808 50.327 1.00 9.14 ? 57 ARG M CD 1 ATOM 417 N NE . ARG A 1 57 ? 70.133 113.165 49.340 1.00 10.22 ? 57 ARG M NE 1 ATOM 418 C CZ . ARG A 1 57 ? 70.286 111.850 49.224 1.00 10.09 ? 57 ARG M CZ 1 ATOM 419 N NH1 . ARG A 1 57 ? 69.635 111.030 50.040 1.00 11.62 ? 57 ARG M NH1 1 ATOM 420 N NH2 . ARG A 1 57 ? 71.077 111.356 48.280 1.00 10.67 ? 57 ARG M NH2 1 ATOM 421 N N . TYR A 1 58 ? 67.251 118.589 50.211 1.00 8.04 ? 58 TYR M N 1 ATOM 422 C CA . TYR A 1 58 ? 66.764 119.310 49.037 1.00 8.06 ? 58 TYR M CA 1 ATOM 423 C C . TYR A 1 58 ? 66.119 120.620 49.472 1.00 9.39 ? 58 TYR M C 1 ATOM 424 O O . TYR A 1 58 ? 64.899 120.783 49.387 1.00 8.73 ? 58 TYR M O 1 ATOM 425 C CB . TYR A 1 58 ? 65.731 118.446 48.307 1.00 7.77 ? 58 TYR M CB 1 ATOM 426 C CG . TYR A 1 58 ? 66.235 117.070 47.941 1.00 7.50 ? 58 TYR M CG 1 ATOM 427 C CD1 . TYR A 1 58 ? 67.132 116.895 46.891 1.00 11.42 ? 58 TYR M CD1 1 ATOM 428 C CD2 . TYR A 1 58 ? 65.817 115.941 48.649 1.00 8.63 ? 58 TYR M CD2 1 ATOM 429 C CE1 . TYR A 1 58 ? 67.604 115.636 46.553 1.00 12.22 ? 58 TYR M CE1 1 ATOM 430 C CE2 . TYR A 1 58 ? 66.281 114.675 48.318 1.00 10.51 ? 58 TYR M CE2 1 ATOM 431 C CZ . TYR A 1 58 ? 67.170 114.529 47.271 1.00 12.86 ? 58 TYR M CZ 1 ATOM 432 O OH . TYR A 1 58 ? 67.617 113.279 46.930 1.00 13.54 ? 58 TYR M OH 1 ATOM 433 N N . PRO A 1 59 ? 66.935 121.592 49.911 1.00 10.71 ? 59 PRO M N 1 ATOM 434 C CA . PRO A 1 59 ? 66.414 122.887 50.361 1.00 10.46 ? 59 PRO M CA 1 ATOM 435 C C . PRO A 1 59 ? 65.499 123.603 49.369 1.00 12.49 ? 59 PRO M C 1 ATOM 436 O O . PRO A 1 59 ? 64.509 124.222 49.771 1.00 13.42 ? 59 PRO M O 1 ATOM 437 C CB . PRO A 1 59 ? 67.685 123.683 50.668 1.00 12.74 ? 59 PRO M CB 1 ATOM 438 C CG . PRO A 1 59 ? 68.727 123.042 49.800 1.00 15.57 ? 59 PRO M CG 1 ATOM 439 C CD . PRO A 1 59 ? 68.407 121.581 49.943 1.00 11.67 ? 59 PRO M CD 1 ATOM 440 N N . ASN A 1 60 ? 65.812 123.499 48.080 1.00 12.48 ? 60 ASN M N 1 ATOM 441 C CA . ASN A 1 60 ? 64.999 124.139 47.048 1.00 16.69 ? 60 ASN M CA 1 ATOM 442 C C . ASN A 1 60 ? 63.581 123.559 47.007 1.00 16.41 ? 60 ASN M C 1 ATOM 443 O O . ASN A 1 60 ? 62.638 124.237 46.601 1.00 17.91 ? 60 ASN M O 1 ATOM 444 C CB . ASN A 1 60 ? 65.666 123.998 45.675 1.00 23.52 ? 60 ASN M CB 1 ATOM 445 C CG . ASN A 1 60 ? 65.680 122.564 45.172 1.00 28.91 ? 60 ASN M CG 1 ATOM 446 O OD1 . ASN A 1 60 ? 66.029 121.636 45.906 1.00 35.41 ? 60 ASN M OD1 1 ATOM 447 N ND2 . ASN A 1 60 ? 65.292 122.377 43.916 1.00 35.59 ? 60 ASN M ND2 1 ATOM 448 N N . LYS A 1 61 ? 63.435 122.308 47.436 1.00 11.77 ? 61 LYS M N 1 ATOM 449 C CA . LYS A 1 61 ? 62.130 121.651 47.450 1.00 11.76 ? 61 LYS M CA 1 ATOM 450 C C . LYS A 1 61 ? 61.326 121.921 48.717 1.00 11.88 ? 61 LYS M C 1 ATOM 451 O O . LYS A 1 61 ? 60.114 121.705 48.740 1.00 12.83 ? 61 LYS M O 1 ATOM 452 C CB . LYS A 1 61 ? 62.280 120.139 47.263 1.00 13.06 ? 61 LYS M CB 1 ATOM 453 C CG . LYS A 1 61 ? 62.869 119.732 45.930 1.00 14.98 ? 61 LYS M CG 1 ATOM 454 C CD . LYS A 1 61 ? 62.720 118.233 45.733 1.00 13.97 ? 61 LYS M CD 1 ATOM 455 C CE . LYS A 1 61 ? 63.227 117.793 44.388 1.00 18.15 ? 61 LYS M CE 1 ATOM 456 N NZ . LYS A 1 61 ? 62.877 116.373 44.140 1.00 13.75 ? 61 LYS M NZ 1 ATOM 457 N N . SER A 1 62 ? 61.997 122.363 49.778 1.00 13.39 ? 62 SER M N 1 ATOM 458 C CA . SER A 1 62 ? 61.310 122.644 51.039 1.00 13.96 ? 62 SER M CA 1 ATOM 459 C C . SER A 1 62 ? 60.434 123.885 50.898 1.00 13.42 ? 62 SER M C 1 ATOM 460 O O . SER A 1 62 ? 59.398 124.004 51.551 1.00 13.52 ? 62 SER M O 1 ATOM 461 C CB . SER A 1 62 ? 62.316 122.840 52.178 1.00 16.29 ? 62 SER M CB 1 ATOM 462 O OG . SER A 1 62 ? 63.064 124.032 52.014 1.00 19.68 ? 62 SER M OG 1 ATOM 463 N N . GLY A 1 63 ? 60.867 124.802 50.038 1.00 12.13 ? 63 GLY M N 1 ATOM 464 C CA . GLY A 1 63 ? 60.130 126.030 49.805 1.00 13.28 ? 63 GLY M CA 1 ATOM 465 C C . GLY A 1 63 ? 61.020 127.023 49.082 1.00 14.61 ? 63 GLY M C 1 ATOM 466 O O . GLY A 1 63 ? 62.240 126.847 49.060 1.00 14.30 ? 63 GLY M O 1 ATOM 467 N N . PRO A 1 64 ? 60.447 128.063 48.454 1.00 15.47 ? 64 PRO M N 1 ATOM 468 C CA . PRO A 1 64 ? 61.249 129.063 47.738 1.00 18.04 ? 64 PRO M CA 1 ATOM 469 C C . PRO A 1 64 ? 62.218 129.780 48.678 1.00 18.41 ? 64 PRO M C 1 ATOM 470 O O . PRO A 1 64 ? 63.283 130.238 48.262 1.00 19.94 ? 64 PRO M O 1 ATOM 471 C CB . PRO A 1 64 ? 60.186 130.020 47.197 1.00 17.79 ? 64 PRO M CB 1 ATOM 472 C CG . PRO A 1 64 ? 59.015 129.118 46.969 1.00 20.07 ? 64 PRO M CG 1 ATOM 473 C CD . PRO A 1 64 ? 59.009 128.297 48.238 1.00 16.58 ? 64 PRO M CD 1 ATOM 474 N N . ASP A 1 65 ? 61.842 129.848 49.951 1.00 16.28 ? 65 ASP M N 1 ATOM 475 C CA . ASP A 1 65 ? 62.647 130.491 50.984 1.00 18.17 ? 65 ASP M CA 1 ATOM 476 C C . ASP A 1 65 ? 63.544 129.490 51.715 1.00 16.46 ? 65 ASP M C 1 ATOM 477 O O . ASP A 1 65 ? 64.248 129.853 52.661 1.00 16.43 ? 65 ASP M O 1 ATOM 478 C CB . ASP A 1 65 ? 61.729 131.195 51.994 1.00 18.95 ? 65 ASP M CB 1 ATOM 479 C CG . ASP A 1 65 ? 60.728 130.244 52.666 1.00 20.43 ? 65 ASP M CG 1 ATOM 480 O OD1 . ASP A 1 65 ? 60.632 129.059 52.273 1.00 14.94 ? 65 ASP M OD1 1 ATOM 481 O OD2 . ASP A 1 65 ? 60.030 130.691 53.599 1.00 21.80 ? 65 ASP M OD2 1 ATOM 482 N N . HIS A 1 66 ? 63.507 128.234 51.273 1.00 14.89 ? 66 HIS M N 1 ATOM 483 C CA . HIS A 1 66 ? 64.282 127.155 51.889 1.00 15.12 ? 66 HIS M CA 1 ATOM 484 C C . HIS A 1 66 ? 63.862 126.926 53.339 1.00 14.93 ? 66 HIS M C 1 ATOM 485 O O . HIS A 1 66 ? 64.594 126.314 54.118 1.00 15.24 ? 66 HIS M O 1 ATOM 486 C CB . HIS A 1 66 ? 65.788 127.434 51.813 1.00 15.81 ? 66 HIS M CB 1 ATOM 487 C CG . HIS A 1 66 ? 66.345 127.374 50.430 1.00 16.82 ? 66 HIS M CG 1 ATOM 488 N ND1 . HIS A 1 66 ? 67.699 127.299 50.173 1.00 21.45 ? 66 HIS M ND1 1 ATOM 489 C CD2 . HIS A 1 66 ? 65.740 127.382 49.215 1.00 18.29 ? 66 HIS M CD2 1 ATOM 490 C CE1 . HIS A 1 66 ? 67.902 127.263 48.873 1.00 21.82 ? 66 HIS M CE1 1 ATOM 491 N NE2 . HIS A 1 66 ? 66.723 127.313 48.266 1.00 19.47 ? 66 HIS M NE2 1 ATOM 492 N N . GLY A 1 67 ? 62.673 127.410 53.688 1.00 14.22 ? 67 GLY M N 1 ATOM 493 C CA . GLY A 1 67 ? 62.165 127.247 55.037 1.00 13.60 ? 67 GLY M CA 1 ATOM 494 C C . GLY A 1 67 ? 61.786 125.805 55.315 1.00 13.69 ? 67 GLY M C 1 ATOM 495 O O . GLY A 1 67 ? 61.460 125.053 54.394 1.00 14.97 ? 67 GLY M O 1 ATOM 496 N N . ASN A 1 68 ? 61.833 125.418 56.583 1.00 11.73 ? 68 ASN M N 1 ATOM 497 C CA . ASN A 1 68 ? 61.490 124.059 56.981 1.00 10.96 ? 68 ASN M CA 1 ATOM 498 C C . ASN A 1 68 ? 60.808 124.060 58.348 1.00 10.31 ? 68 ASN M C 1 ATOM 499 O O . ASN A 1 68 ? 60.521 125.124 58.905 1.00 10.39 ? 68 ASN M O 1 ATOM 500 C CB . ASN A 1 68 ? 62.747 123.170 56.974 1.00 9.27 ? 68 ASN M CB 1 ATOM 501 C CG . ASN A 1 68 ? 63.861 123.725 57.838 1.00 10.57 ? 68 ASN M CG 1 ATOM 502 O OD1 . ASN A 1 68 ? 63.636 124.095 58.980 1.00 9.76 ? 68 ASN M OD1 1 ATOM 503 N ND2 . ASN A 1 68 ? 65.073 123.789 57.288 1.00 11.60 ? 68 ASN M ND2 1 ATOM 504 N N . GLY A 1 69 ? 60.532 122.872 58.880 1.00 9.73 ? 69 GLY M N 1 ATOM 505 C CA . GLY A 1 69 ? 59.867 122.774 60.167 1.00 9.79 ? 69 GLY M CA 1 ATOM 506 C C . GLY A 1 69 ? 60.763 122.714 61.392 1.00 9.59 ? 69 GLY M C 1 ATOM 507 O O . GLY A 1 69 ? 60.337 122.238 62.436 1.00 11.40 ? 69 GLY M O 1 ATOM 508 N N . ASP A 1 70 ? 61.990 123.215 61.284 1.00 9.38 ? 70 ASP M N 1 ATOM 509 C CA . ASP A 1 70 ? 62.922 123.185 62.408 1.00 8.34 ? 70 ASP M CA 1 ATOM 510 C C . ASP A 1 70 ? 62.393 123.808 63.686 1.00 11.91 ? 70 ASP M C 1 ATOM 511 O O . ASP A 1 70 ? 62.498 123.225 64.765 1.00 11.74 ? 70 ASP M O 1 ATOM 512 C CB . ASP A 1 70 ? 64.225 123.880 62.036 1.00 9.26 ? 70 ASP M CB 1 ATOM 513 C CG . ASP A 1 70 ? 65.178 122.971 61.304 1.00 9.66 ? 70 ASP M CG 1 ATOM 514 O OD1 . ASP A 1 70 ? 64.833 121.799 61.028 1.00 8.79 ? 70 ASP M OD1 1 ATOM 515 O OD2 . ASP A 1 70 ? 66.281 123.450 61.012 1.00 8.38 ? 70 ASP M OD2 1 ATOM 516 N N . THR A 1 71 ? 61.831 125.000 63.558 1.00 12.40 ? 71 THR M N 1 ATOM 517 C CA . THR A 1 71 ? 61.301 125.687 64.723 1.00 16.96 ? 71 THR M CA 1 ATOM 518 C C . THR A 1 71 ? 59.846 126.056 64.496 1.00 17.24 ? 71 THR M C 1 ATOM 519 O O . THR A 1 71 ? 59.014 125.874 65.381 1.00 17.04 ? 71 THR M O 1 ATOM 520 C CB . THR A 1 71 ? 62.121 126.953 65.042 1.00 18.03 ? 71 THR M CB 1 ATOM 521 O OG1 . THR A 1 71 ? 62.182 127.789 63.882 1.00 20.29 ? 71 THR M OG1 1 ATOM 522 C CG2 . THR A 1 71 ? 63.528 126.583 65.447 1.00 15.24 ? 71 THR M CG2 1 ATOM 523 N N . THR A 1 72 ? 59.543 126.513 63.281 1.00 18.83 ? 72 THR M N 1 ATOM 524 C CA . THR A 1 72 ? 58.197 126.924 62.888 1.00 19.80 ? 72 THR M CA 1 ATOM 525 C C . THR A 1 72 ? 57.500 127.709 64.010 1.00 19.38 ? 72 THR M C 1 ATOM 526 O O . THR A 1 72 ? 58.148 128.510 64.683 1.00 17.56 ? 72 THR M O 1 ATOM 527 C CB . THR A 1 72 ? 57.357 125.715 62.342 1.00 19.52 ? 72 THR M CB 1 ATOM 528 O OG1 . THR A 1 72 ? 56.056 126.162 61.946 1.00 17.07 ? 72 THR M OG1 1 ATOM 529 C CG2 . THR A 1 72 ? 57.233 124.593 63.364 1.00 21.23 ? 72 THR M CG2 1 ATOM 530 N N . CYS A 1 73 ? 56.209 127.484 64.236 1.00 20.42 ? 73 CYS M N 1 ATOM 531 C CA . CYS A 1 73 ? 55.508 128.219 65.285 1.00 19.71 ? 73 CYS M CA 1 ATOM 532 C C . CYS A 1 73 ? 55.795 127.726 66.704 1.00 20.58 ? 73 CYS M C 1 ATOM 533 O O . CYS A 1 73 ? 55.226 128.239 67.668 1.00 19.35 ? 73 CYS M O 1 ATOM 534 C CB . CYS A 1 73 ? 54.010 128.241 65.020 1.00 23.89 ? 73 CYS M CB 1 ATOM 535 S SG . CYS A 1 73 ? 53.289 126.624 64.836 1.00 23.35 ? 73 CYS M SG 1 ATOM 536 N N . ASP A 1 74 ? 56.665 126.723 66.817 1.00 18.06 ? 74 ASP M N 1 ATOM 537 C CA . ASP A 1 74 ? 57.075 126.163 68.107 1.00 19.18 ? 74 ASP M CA 1 ATOM 538 C C . ASP A 1 74 ? 55.908 125.750 69.004 1.00 20.83 ? 74 ASP M C 1 ATOM 539 O O . ASP A 1 74 ? 55.804 126.189 70.152 1.00 18.56 ? 74 ASP M O 1 ATOM 540 C CB . ASP A 1 74 ? 58.000 127.157 68.841 1.00 19.13 ? 74 ASP M CB 1 ATOM 541 C CG . ASP A 1 74 ? 58.714 126.540 70.046 1.00 23.75 ? 74 ASP M CG 1 ATOM 542 O OD1 . ASP A 1 74 ? 58.538 125.335 70.323 1.00 22.92 ? 74 ASP M OD1 1 ATOM 543 O OD2 . ASP A 1 74 ? 59.461 127.276 70.727 1.00 25.47 ? 74 ASP M OD2 1 ATOM 544 N N . SER A 1 75 ? 55.030 124.899 68.485 1.00 18.94 ? 75 SER M N 1 ATOM 545 C CA . SER A 1 75 ? 53.905 124.433 69.283 1.00 18.82 ? 75 SER M CA 1 ATOM 546 C C . SER A 1 75 ? 54.364 123.453 70.355 1.00 19.51 ? 75 SER M C 1 ATOM 547 O O . SER A 1 75 ? 53.577 123.045 71.207 1.00 16.91 ? 75 SER M O 1 ATOM 548 C CB . SER A 1 75 ? 52.815 123.826 68.407 1.00 19.31 ? 75 SER M CB 1 ATOM 549 O OG . SER A 1 75 ? 52.093 124.856 67.755 1.00 19.83 ? 75 SER M OG 1 ATOM 550 N N . PHE A 1 76 ? 55.634 123.058 70.300 1.00 18.14 ? 76 PHE M N 1 ATOM 551 C CA . PHE A 1 76 ? 56.174 122.172 71.320 1.00 20.60 ? 76 PHE M CA 1 ATOM 552 C C . PHE A 1 76 ? 56.149 122.971 72.623 1.00 20.37 ? 76 PHE M C 1 ATOM 553 O O . PHE A 1 76 ? 55.684 122.487 73.654 1.00 18.67 ? 76 PHE M O 1 ATOM 554 C CB . PHE A 1 76 ? 57.612 121.763 71.000 1.00 22.16 ? 76 PHE M CB 1 ATOM 555 C CG . PHE A 1 76 ? 58.298 121.048 72.134 1.00 23.55 ? 76 PHE M CG 1 ATOM 556 C CD1 . PHE A 1 76 ? 58.068 119.697 72.362 1.00 25.96 ? 76 PHE M CD1 1 ATOM 557 C CD2 . PHE A 1 76 ? 59.156 121.736 72.989 1.00 25.88 ? 76 PHE M CD2 1 ATOM 558 C CE1 . PHE A 1 76 ? 58.680 119.040 73.427 1.00 28.96 ? 76 PHE M CE1 1 ATOM 559 C CE2 . PHE A 1 76 ? 59.772 121.089 74.056 1.00 28.69 ? 76 PHE M CE2 1 ATOM 560 C CZ . PHE A 1 76 ? 59.534 119.739 74.275 1.00 27.61 ? 76 PHE M CZ 1 ATOM 561 N N . SER A 1 77 ? 56.637 124.207 72.552 1.00 22.08 ? 77 SER M N 1 ATOM 562 C CA . SER A 1 77 ? 56.670 125.091 73.712 1.00 22.05 ? 77 SER M CA 1 ATOM 563 C C . SER A 1 77 ? 55.339 125.808 73.909 1.00 19.83 ? 77 SER M C 1 ATOM 564 O O . SER A 1 77 ? 54.882 125.991 75.037 1.00 19.40 ? 77 SER M O 1 ATOM 565 C CB . SER A 1 77 ? 57.767 126.156 73.552 1.00 22.00 ? 77 SER M CB 1 ATOM 566 O OG . SER A 1 77 ? 59.042 125.582 73.322 1.00 23.03 ? 77 SER M OG 1 ATOM 567 N N . TYR A 1 78 ? 54.706 126.187 72.805 1.00 17.75 ? 78 TYR M N 1 ATOM 568 C CA . TYR A 1 78 ? 53.461 126.945 72.867 1.00 18.79 ? 78 TYR M CA 1 ATOM 569 C C . TYR A 1 78 ? 52.153 126.211 72.590 1.00 15.93 ? 78 TYR M C 1 ATOM 570 O O . TYR A 1 78 ? 51.192 126.819 72.114 1.00 15.87 ? 78 TYR M O 1 ATOM 571 C CB . TYR A 1 78 ? 53.587 128.181 71.972 1.00 17.81 ? 78 TYR M CB 1 ATOM 572 C CG . TYR A 1 78 ? 54.846 128.962 72.263 1.00 23.36 ? 78 TYR M CG 1 ATOM 573 C CD1 . TYR A 1 78 ? 55.137 129.384 73.558 1.00 21.95 ? 78 TYR M CD1 1 ATOM 574 C CD2 . TYR A 1 78 ? 55.778 129.221 71.260 1.00 23.92 ? 78 TYR M CD2 1 ATOM 575 C CE1 . TYR A 1 78 ? 56.329 130.037 73.853 1.00 26.28 ? 78 TYR M CE1 1 ATOM 576 C CE2 . TYR A 1 78 ? 56.976 129.875 71.543 1.00 25.22 ? 78 TYR M CE2 1 ATOM 577 C CZ . TYR A 1 78 ? 57.243 130.278 72.842 1.00 24.85 ? 78 TYR M CZ 1 ATOM 578 O OH . TYR A 1 78 ? 58.426 130.909 73.135 1.00 28.14 ? 78 TYR M OH 1 ATOM 579 N N . TRP A 1 79 ? 52.094 124.926 72.933 1.00 17.85 ? 79 TRP M N 1 ATOM 580 C CA . TRP A 1 79 ? 50.875 124.138 72.730 1.00 15.53 ? 79 TRP M CA 1 ATOM 581 C C . TRP A 1 79 ? 49.690 124.753 73.483 1.00 15.15 ? 79 TRP M C 1 ATOM 582 O O . TRP A 1 79 ? 48.548 124.684 73.028 1.00 11.41 ? 79 TRP M O 1 ATOM 583 C CB . TRP A 1 79 ? 51.085 122.688 73.183 1.00 20.67 ? 79 TRP M CB 1 ATOM 584 C CG . TRP A 1 79 ? 51.539 122.558 74.609 1.00 20.99 ? 79 TRP M CG 1 ATOM 585 C CD1 . TRP A 1 79 ? 52.825 122.616 75.070 1.00 22.20 ? 79 TRP M CD1 1 ATOM 586 C CD2 . TRP A 1 79 ? 50.705 122.370 75.762 1.00 21.91 ? 79 TRP M CD2 1 ATOM 587 N NE1 . TRP A 1 79 ? 52.843 122.482 76.439 1.00 21.46 ? 79 TRP M NE1 1 ATOM 588 C CE2 . TRP A 1 79 ? 51.561 122.333 76.887 1.00 22.91 ? 79 TRP M CE2 1 ATOM 589 C CE3 . TRP A 1 79 ? 49.325 122.238 75.950 1.00 19.62 ? 79 TRP M CE3 1 ATOM 590 C CZ2 . TRP A 1 79 ? 51.071 122.160 78.190 1.00 23.83 ? 79 TRP M CZ2 1 ATOM 591 C CZ3 . TRP A 1 79 ? 48.841 122.068 77.243 1.00 23.31 ? 79 TRP M CZ3 1 ATOM 592 C CH2 . TRP A 1 79 ? 49.714 122.033 78.347 1.00 23.52 ? 79 TRP M CH2 1 ATOM 593 N N . GLN A 1 80 ? 49.968 125.367 74.631 1.00 13.51 ? 80 GLN M N 1 ATOM 594 C CA . GLN A 1 80 ? 48.914 125.993 75.425 1.00 14.11 ? 80 GLN M CA 1 ATOM 595 C C . GLN A 1 80 ? 48.303 127.164 74.661 1.00 12.41 ? 80 GLN M C 1 ATOM 596 O O . GLN A 1 80 ? 47.103 127.424 74.767 1.00 12.92 ? 80 GLN M O 1 ATOM 597 C CB . GLN A 1 80 ? 49.457 126.459 76.780 1.00 16.56 ? 80 GLN M CB 1 ATOM 598 C CG . GLN A 1 80 ? 48.407 127.098 77.689 1.00 20.83 ? 80 GLN M CG 1 ATOM 599 C CD . GLN A 1 80 ? 47.208 126.196 77.938 1.00 23.35 ? 80 GLN M CD 1 ATOM 600 O OE1 . GLN A 1 80 ? 46.073 126.551 77.615 1.00 26.74 ? 80 GLN M OE1 1 ATOM 601 N NE2 . GLN A 1 80 ? 47.456 125.026 78.511 1.00 22.12 ? 80 GLN M NE2 1 ATOM 602 N N . LYS A 1 81 ? 49.134 127.859 73.884 1.00 12.44 ? 81 LYS M N 1 ATOM 603 C CA . LYS A 1 81 ? 48.663 128.988 73.086 1.00 12.47 ? 81 LYS M CA 1 ATOM 604 C C . LYS A 1 81 ? 47.710 128.485 72.009 1.00 12.88 ? 81 LYS M C 1 ATOM 605 O O . LYS A 1 81 ? 46.816 129.215 71.579 1.00 12.24 ? 81 LYS M O 1 ATOM 606 C CB . LYS A 1 81 ? 49.833 129.735 72.438 1.00 15.94 ? 81 LYS M CB 1 ATOM 607 C CG . LYS A 1 81 ? 50.856 130.277 73.424 1.00 23.30 ? 81 LYS M CG 1 ATOM 608 C CD . LYS A 1 81 ? 50.238 131.257 74.406 1.00 27.76 ? 81 LYS M CD 1 ATOM 609 C CE . LYS A 1 81 ? 51.286 131.784 75.376 1.00 30.29 ? 81 LYS M CE 1 ATOM 610 N NZ . LYS A 1 81 ? 50.696 132.689 76.400 1.00 31.57 ? 81 LYS M NZ 1 ATOM 611 N N . ASP A 1 82 ? 47.927 127.254 71.548 1.00 12.59 ? 82 ASP M N 1 ATOM 612 C CA . ASP A 1 82 ? 47.054 126.659 70.539 1.00 12.35 ? 82 ASP M CA 1 ATOM 613 C C . ASP A 1 82 ? 45.687 126.421 71.185 1.00 13.34 ? 82 ASP M C 1 ATOM 614 O O . ASP A 1 82 ? 44.651 126.739 70.603 1.00 12.74 ? 82 ASP M O 1 ATOM 615 C CB . ASP A 1 82 ? 47.628 125.331 70.027 1.00 13.29 ? 82 ASP M CB 1 ATOM 616 C CG . ASP A 1 82 ? 48.930 125.502 69.252 1.00 15.20 ? 82 ASP M CG 1 ATOM 617 O OD1 . ASP A 1 82 ? 49.239 126.628 68.807 1.00 13.56 ? 82 ASP M OD1 1 ATOM 618 O OD2 . ASP A 1 82 ? 49.644 124.492 69.076 1.00 16.37 ? 82 ASP M OD2 1 ATOM 619 N N . ILE A 1 83 ? 45.695 125.861 72.393 1.00 12.49 ? 83 ILE M N 1 ATOM 620 C CA . ILE A 1 83 ? 44.455 125.603 73.121 1.00 12.58 ? 83 ILE M CA 1 ATOM 621 C C . ILE A 1 83 ? 43.725 126.923 73.377 1.00 13.81 ? 83 ILE M C 1 ATOM 622 O O . ILE A 1 83 ? 42.502 126.988 73.284 1.00 12.11 ? 83 ILE M O 1 ATOM 623 C CB . ILE A 1 83 ? 44.720 124.887 74.461 1.00 13.14 ? 83 ILE M CB 1 ATOM 624 C CG1 . ILE A 1 83 ? 45.342 123.512 74.206 1.00 14.33 ? 83 ILE M CG1 1 ATOM 625 C CG2 . ILE A 1 83 ? 43.421 124.733 75.252 1.00 15.22 ? 83 ILE M CG2 1 ATOM 626 C CD1 . ILE A 1 83 ? 45.675 122.746 75.468 1.00 14.72 ? 83 ILE M CD1 1 ATOM 627 N N . ASP A 1 84 ? 44.483 127.979 73.664 1.00 14.29 ? 84 ASP M N 1 ATOM 628 C CA . ASP A 1 84 ? 43.891 129.293 73.915 1.00 15.14 ? 84 ASP M CA 1 ATOM 629 C C . ASP A 1 84 ? 43.150 129.824 72.687 1.00 15.15 ? 84 ASP M C 1 ATOM 630 O O . ASP A 1 84 ? 42.089 130.439 72.819 1.00 15.32 ? 84 ASP M O 1 ATOM 631 C CB . ASP A 1 84 ? 44.956 130.296 74.369 1.00 19.36 ? 84 ASP M CB 1 ATOM 632 C CG . ASP A 1 84 ? 45.544 129.958 75.734 1.00 24.19 ? 84 ASP M CG 1 ATOM 633 O OD1 . ASP A 1 84 ? 44.921 129.193 76.502 1.00 23.33 ? 84 ASP M OD1 1 ATOM 634 O OD2 . ASP A 1 84 ? 46.643 130.465 76.042 1.00 25.98 ? 84 ASP M OD2 1 ATOM 635 N N . VAL A 1 85 ? 43.707 129.590 71.499 1.00 12.91 ? 85 VAL M N 1 ATOM 636 C CA . VAL A 1 85 ? 43.074 130.020 70.251 1.00 13.87 ? 85 VAL M CA 1 ATOM 637 C C . VAL A 1 85 ? 41.757 129.272 70.077 1.00 12.72 ? 85 VAL M C 1 ATOM 638 O O . VAL A 1 85 ? 40.736 129.860 69.721 1.00 11.56 ? 85 VAL M O 1 ATOM 639 C CB . VAL A 1 85 ? 43.966 129.717 69.020 1.00 16.82 ? 85 VAL M CB 1 ATOM 640 C CG1 . VAL A 1 85 ? 43.197 129.967 67.719 1.00 20.10 ? 85 VAL M CG1 1 ATOM 641 C CG2 . VAL A 1 85 ? 45.198 130.571 69.060 1.00 20.57 ? 85 VAL M CG2 1 ATOM 642 N N . LEU A 1 86 ? 41.793 127.966 70.331 1.00 10.95 ? 86 LEU M N 1 ATOM 643 C CA . LEU A 1 86 ? 40.608 127.122 70.209 1.00 9.57 ? 86 LEU M CA 1 ATOM 644 C C . LEU A 1 86 ? 39.536 127.554 71.200 1.00 11.20 ? 86 LEU M C 1 ATOM 645 O O . LEU A 1 86 ? 38.347 127.593 70.872 1.00 10.12 ? 86 LEU M O 1 ATOM 646 C CB . LEU A 1 86 ? 40.989 125.663 70.445 1.00 11.06 ? 86 LEU M CB 1 ATOM 647 C CG . LEU A 1 86 ? 41.832 125.083 69.312 1.00 10.50 ? 86 LEU M CG 1 ATOM 648 C CD1 . LEU A 1 86 ? 42.659 123.916 69.801 1.00 9.81 ? 86 LEU M CD1 1 ATOM 649 C CD2 . LEU A 1 86 ? 40.919 124.682 68.165 1.00 11.85 ? 86 LEU M CD2 1 ATOM 650 N N . ASP A 1 87 ? 39.978 127.898 72.407 1.00 12.58 ? 87 ASP M N 1 ATOM 651 C CA . ASP A 1 87 ? 39.085 128.349 73.473 1.00 15.14 ? 87 ASP M CA 1 ATOM 652 C C . ASP A 1 87 ? 38.432 129.669 73.057 1.00 14.54 ? 87 ASP M C 1 ATOM 653 O O . ASP A 1 87 ? 37.226 129.856 73.224 1.00 14.63 ? 87 ASP M O 1 ATOM 654 C CB . ASP A 1 87 ? 39.889 128.523 74.768 1.00 15.27 ? 87 ASP M CB 1 ATOM 655 C CG . ASP A 1 87 ? 39.014 128.803 75.982 1.00 22.37 ? 87 ASP M CG 1 ATOM 656 O OD1 . ASP A 1 87 ? 37.886 128.272 76.061 1.00 23.02 ? 87 ASP M OD1 1 ATOM 657 O OD2 . ASP A 1 87 ? 39.477 129.538 76.877 1.00 27.52 ? 87 ASP M OD2 1 ATOM 658 N N . GLU A 1 88 ? 39.232 130.561 72.477 1.00 14.91 ? 88 GLU M N 1 ATOM 659 C CA . GLU A 1 88 ? 38.753 131.860 72.015 1.00 16.66 ? 88 GLU M CA 1 ATOM 660 C C . GLU A 1 88 ? 37.701 131.687 70.918 1.00 16.10 ? 88 GLU M C 1 ATOM 661 O O . GLU A 1 88 ? 36.689 132.388 70.898 1.00 16.48 ? 88 GLU M O 1 ATOM 662 C CB . GLU A 1 88 ? 39.932 132.694 71.507 1.00 19.33 ? 88 GLU M CB 1 ATOM 663 C CG . GLU A 1 88 ? 39.614 134.153 71.238 1.00 23.80 ? 88 GLU M CG 1 ATOM 664 C CD . GLU A 1 88 ? 40.853 134.979 70.912 1.00 27.49 ? 88 GLU M CD 1 ATOM 665 O OE1 . GLU A 1 88 ? 41.961 134.403 70.810 1.00 29.36 ? 88 GLU M OE1 1 ATOM 666 O OE2 . GLU A 1 88 ? 40.716 136.211 70.757 1.00 30.14 ? 88 GLU M OE2 1 ATOM 667 N N . LEU A 1 89 ? 37.929 130.725 70.029 1.00 13.54 ? 89 LEU M N 1 ATOM 668 C CA . LEU A 1 89 ? 36.997 130.439 68.941 1.00 12.00 ? 89 LEU M CA 1 ATOM 669 C C . LEU A 1 89 ? 35.750 129.705 69.422 1.00 12.44 ? 89 LEU M C 1 ATOM 670 O O . LEU A 1 89 ? 34.751 129.643 68.702 1.00 14.43 ? 89 LEU M O 1 ATOM 671 C CB . LEU A 1 89 ? 37.672 129.552 67.891 1.00 11.16 ? 89 LEU M CB 1 ATOM 672 C CG . LEU A 1 89 ? 38.741 130.158 66.988 1.00 11.65 ? 89 LEU M CG 1 ATOM 673 C CD1 . LEU A 1 89 ? 39.447 129.039 66.225 1.00 13.20 ? 89 LEU M CD1 1 ATOM 674 C CD2 . LEU A 1 89 ? 38.099 131.145 66.030 1.00 14.76 ? 89 LEU M CD2 1 ATOM 675 N N . ASN A 1 90 ? 35.817 129.150 70.631 1.00 11.49 ? 90 ASN M N 1 ATOM 676 C CA . ASN A 1 90 ? 34.731 128.350 71.206 1.00 11.37 ? 90 ASN M CA 1 ATOM 677 C C . ASN A 1 90 ? 34.591 127.122 70.293 1.00 11.89 ? 90 ASN M C 1 ATOM 678 O O . ASN A 1 90 ? 33.495 126.608 70.059 1.00 12.72 ? 90 ASN M O 1 ATOM 679 C CB . ASN A 1 90 ? 33.415 129.142 71.283 1.00 13.39 ? 90 ASN M CB 1 ATOM 680 C CG . ASN A 1 90 ? 32.442 128.583 72.325 1.00 18.70 ? 90 ASN M CG 1 ATOM 681 O OD1 . ASN A 1 90 ? 32.759 127.648 73.071 1.00 17.44 ? 90 ASN M OD1 1 ATOM 682 N ND2 . ASN A 1 90 ? 31.254 129.182 72.380 1.00 19.45 ? 90 ASN M ND2 1 ATOM 683 N N . ALA A 1 91 ? 35.730 126.673 69.772 1.00 10.77 ? 91 ALA M N 1 ATOM 684 C CA . ALA A 1 91 ? 35.780 125.509 68.900 1.00 9.85 ? 91 ALA M CA 1 ATOM 685 C C . ALA A 1 91 ? 35.396 124.267 69.690 1.00 10.05 ? 91 ALA M C 1 ATOM 686 O O . ALA A 1 91 ? 35.670 124.171 70.890 1.00 13.50 ? 91 ALA M O 1 ATOM 687 C CB . ALA A 1 91 ? 37.185 125.341 68.328 1.00 12.70 ? 91 ALA M CB 1 ATOM 688 N N . THR A 1 92 ? 34.754 123.321 69.017 1.00 9.91 ? 92 THR M N 1 ATOM 689 C CA . THR A 1 92 ? 34.361 122.075 69.661 1.00 9.99 ? 92 THR M CA 1 ATOM 690 C C . THR A 1 92 ? 35.195 120.909 69.141 1.00 10.37 ? 92 THR M C 1 ATOM 691 O O . THR A 1 92 ? 35.055 119.778 69.603 1.00 9.84 ? 92 THR M O 1 ATOM 692 C CB . THR A 1 92 ? 32.859 121.792 69.480 1.00 11.08 ? 92 THR M CB 1 ATOM 693 O OG1 . THR A 1 92 ? 32.495 121.967 68.107 1.00 11.39 ? 92 THR M OG1 1 ATOM 694 C CG2 . THR A 1 92 ? 32.042 122.750 70.335 1.00 13.99 ? 92 THR M CG2 1 ATOM 695 N N . GLY A 1 93 ? 36.095 121.206 68.207 1.00 8.75 ? 93 GLY M N 1 ATOM 696 C CA . GLY A 1 93 ? 36.954 120.177 67.659 1.00 9.65 ? 93 GLY M CA 1 ATOM 697 C C . GLY A 1 93 ? 38.313 120.708 67.251 1.00 7.97 ? 93 GLY M C 1 ATOM 698 O O . GLY A 1 93 ? 38.456 121.881 66.912 1.00 8.43 ? 93 GLY M O 1 ATOM 699 N N . TYR A 1 94 ? 39.323 119.848 67.315 1.00 6.89 ? 94 TYR M N 1 ATOM 700 C CA . TYR A 1 94 ? 40.669 120.232 66.917 1.00 5.47 ? 94 TYR M CA 1 ATOM 701 C C . TYR A 1 94 ? 41.372 119.014 66.367 1.00 7.87 ? 94 TYR M C 1 ATOM 702 O O . TYR A 1 94 ? 41.423 117.963 67.011 1.00 7.40 ? 94 TYR M O 1 ATOM 703 C CB . TYR A 1 94 ? 41.475 120.805 68.092 1.00 6.40 ? 94 TYR M CB 1 ATOM 704 C CG . TYR A 1 94 ? 42.925 121.125 67.753 1.00 7.12 ? 94 TYR M CG 1 ATOM 705 C CD1 . TYR A 1 94 ? 43.255 121.833 66.594 1.00 7.40 ? 94 TYR M CD1 1 ATOM 706 C CD2 . TYR A 1 94 ? 43.962 120.741 68.605 1.00 7.86 ? 94 TYR M CD2 1 ATOM 707 C CE1 . TYR A 1 94 ? 44.585 122.148 66.292 1.00 8.35 ? 94 TYR M CE1 1 ATOM 708 C CE2 . TYR A 1 94 ? 45.295 121.056 68.313 1.00 6.46 ? 94 TYR M CE2 1 ATOM 709 C CZ . TYR A 1 94 ? 45.594 121.761 67.155 1.00 9.15 ? 94 TYR M CZ 1 ATOM 710 O OH . TYR A 1 94 ? 46.904 122.088 66.866 1.00 9.57 ? 94 TYR M OH 1 ATOM 711 N N . ARG A 1 95 ? 41.864 119.149 65.144 1.00 7.11 ? 95 ARG M N 1 ATOM 712 C CA . ARG A 1 95 ? 42.589 118.061 64.526 1.00 5.86 ? 95 ARG M CA 1 ATOM 713 C C . ARG A 1 95 ? 44.072 118.378 64.545 1.00 7.10 ? 95 ARG M C 1 ATOM 714 O O . ARG A 1 95 ? 44.498 119.453 64.114 1.00 8.26 ? 95 ARG M O 1 ATOM 715 C CB . ARG A 1 95 ? 42.125 117.823 63.088 1.00 6.20 ? 95 ARG M CB 1 ATOM 716 C CG . ARG A 1 95 ? 42.999 116.816 62.360 1.00 8.04 ? 95 ARG M CG 1 ATOM 717 C CD . ARG A 1 95 ? 42.447 116.443 60.995 1.00 9.59 ? 95 ARG M CD 1 ATOM 718 N NE . ARG A 1 95 ? 43.392 115.563 60.314 1.00 11.48 ? 95 ARG M NE 1 ATOM 719 C CZ . ARG A 1 95 ? 43.931 115.813 59.126 1.00 11.13 ? 95 ARG M CZ 1 ATOM 720 N NH1 . ARG A 1 95 ? 43.607 116.915 58.464 1.00 11.55 ? 95 ARG M NH1 1 ATOM 721 N NH2 . ARG A 1 95 ? 44.840 114.987 58.625 1.00 9.65 ? 95 ARG M NH2 1 ATOM 722 N N . PHE A 1 96 ? 44.844 117.465 65.115 1.00 7.19 ? 96 PHE M N 1 ATOM 723 C CA . PHE A 1 96 ? 46.289 117.613 65.167 1.00 5.78 ? 96 PHE M CA 1 ATOM 724 C C . PHE A 1 96 ? 46.869 116.241 64.890 1.00 7.35 ? 96 PHE M C 1 ATOM 725 O O . PHE A 1 96 ? 46.136 115.249 64.847 1.00 7.31 ? 96 PHE M O 1 ATOM 726 C CB . PHE A 1 96 ? 46.766 118.164 66.528 1.00 7.25 ? 96 PHE M CB 1 ATOM 727 C CG . PHE A 1 96 ? 46.586 117.216 67.690 1.00 7.95 ? 96 PHE M CG 1 ATOM 728 C CD1 . PHE A 1 96 ? 45.425 117.249 68.458 1.00 7.67 ? 96 PHE M CD1 1 ATOM 729 C CD2 . PHE A 1 96 ? 47.589 116.313 68.034 1.00 7.14 ? 96 PHE M CD2 1 ATOM 730 C CE1 . PHE A 1 96 ? 45.272 116.402 69.560 1.00 8.04 ? 96 PHE M CE1 1 ATOM 731 C CE2 . PHE A 1 96 ? 47.443 115.462 69.135 1.00 8.80 ? 96 PHE M CE2 1 ATOM 732 C CZ . PHE A 1 96 ? 46.279 115.508 69.896 1.00 7.57 ? 96 PHE M CZ 1 ATOM 733 N N . SER A 1 97 ? 48.168 116.178 64.635 1.00 6.85 ? 97 SER M N 1 ATOM 734 C CA . SER A 1 97 ? 48.767 114.879 64.383 1.00 7.50 ? 97 SER M CA 1 ATOM 735 C C . SER A 1 97 ? 49.839 114.577 65.410 1.00 6.90 ? 97 SER M C 1 ATOM 736 O O . SER A 1 97 ? 50.375 115.481 66.055 1.00 7.84 ? 97 SER M O 1 ATOM 737 C CB . SER A 1 97 ? 49.350 114.797 62.967 1.00 7.39 ? 97 SER M CB 1 ATOM 738 O OG . SER A 1 97 ? 50.622 115.417 62.878 1.00 8.06 ? 97 SER M OG 1 ATOM 739 N N . ILE A 1 98 ? 50.077 113.290 65.620 1.00 5.73 ? 98 ILE M N 1 ATOM 740 C CA . ILE A 1 98 ? 51.117 112.844 66.535 1.00 6.13 ? 98 ILE M CA 1 ATOM 741 C C . ILE A 1 98 ? 52.356 112.584 65.685 1.00 6.88 ? 98 ILE M C 1 ATOM 742 O O . ILE A 1 98 ? 52.276 111.937 64.638 1.00 7.83 ? 98 ILE M O 1 ATOM 743 C CB . ILE A 1 98 ? 50.714 111.532 67.256 1.00 6.48 ? 98 ILE M CB 1 ATOM 744 C CG1 . ILE A 1 98 ? 49.596 111.806 68.261 1.00 8.57 ? 98 ILE M CG1 1 ATOM 745 C CG2 . ILE A 1 98 ? 51.925 110.904 67.952 1.00 6.59 ? 98 ILE M CG2 1 ATOM 746 C CD1 . ILE A 1 98 ? 49.026 110.550 68.902 1.00 8.91 ? 98 ILE M CD1 1 ATOM 747 N N . ALA A 1 99 ? 53.489 113.139 66.100 1.00 5.99 ? 99 ALA M N 1 ATOM 748 C CA . ALA A 1 99 ? 54.733 112.926 65.375 1.00 6.12 ? 99 ALA M CA 1 ATOM 749 C C . ALA A 1 99 ? 55.306 111.585 65.818 1.00 6.32 ? 99 ALA M C 1 ATOM 750 O O . ALA A 1 99 ? 55.666 111.405 66.980 1.00 8.08 ? 99 ALA M O 1 ATOM 751 C CB . ALA A 1 99 ? 55.723 114.045 65.662 1.00 5.80 ? 99 ALA M CB 1 ATOM 752 N N . TRP A 1 100 ? 55.317 110.631 64.896 1.00 6.62 ? 100 TRP M N 1 ATOM 753 C CA . TRP A 1 100 ? 55.842 109.296 65.148 1.00 6.81 ? 100 TRP M CA 1 ATOM 754 C C . TRP A 1 100 ? 57.257 109.432 65.731 1.00 7.37 ? 100 TRP M C 1 ATOM 755 O O . TRP A 1 100 ? 57.611 108.757 66.698 1.00 8.54 ? 100 TRP M O 1 ATOM 756 C CB . TRP A 1 100 ? 55.862 108.544 63.816 1.00 5.49 ? 100 TRP M CB 1 ATOM 757 C CG . TRP A 1 100 ? 56.178 107.083 63.855 1.00 5.16 ? 100 TRP M CG 1 ATOM 758 C CD1 . TRP A 1 100 ? 56.918 106.403 64.787 1.00 7.64 ? 100 TRP M CD1 1 ATOM 759 C CD2 . TRP A 1 100 ? 55.840 106.134 62.840 1.00 6.12 ? 100 TRP M CD2 1 ATOM 760 N NE1 . TRP A 1 100 ? 57.073 105.088 64.396 1.00 8.45 ? 100 TRP M NE1 1 ATOM 761 C CE2 . TRP A 1 100 ? 56.420 104.901 63.210 1.00 7.19 ? 100 TRP M CE2 1 ATOM 762 C CE3 . TRP A 1 100 ? 55.104 106.213 61.650 1.00 8.55 ? 100 TRP M CE3 1 ATOM 763 C CZ2 . TRP A 1 100 ? 56.290 103.753 62.418 1.00 8.12 ? 100 TRP M CZ2 1 ATOM 764 C CZ3 . TRP A 1 100 ? 54.978 105.075 60.866 1.00 7.57 ? 100 TRP M CZ3 1 ATOM 765 C CH2 . TRP A 1 100 ? 55.566 103.859 61.257 1.00 8.92 ? 100 TRP M CH2 1 ATOM 766 N N . SER A 1 101 ? 58.033 110.358 65.171 1.00 6.61 ? 101 SER M N 1 ATOM 767 C CA . SER A 1 101 ? 59.400 110.607 65.622 1.00 7.01 ? 101 SER M CA 1 ATOM 768 C C . SER A 1 101 ? 59.504 111.171 67.033 1.00 6.95 ? 101 SER M C 1 ATOM 769 O O . SER A 1 101 ? 60.580 111.144 67.630 1.00 7.83 ? 101 SER M O 1 ATOM 770 C CB . SER A 1 101 ? 60.118 111.538 64.643 1.00 7.05 ? 101 SER M CB 1 ATOM 771 O OG . SER A 1 101 ? 60.366 110.857 63.429 1.00 10.68 ? 101 SER M OG 1 ATOM 772 N N . ARG A 1 102 ? 58.401 111.702 67.556 1.00 5.96 ? 102 ARG M N 1 ATOM 773 C CA . ARG A 1 102 ? 58.403 112.252 68.904 1.00 6.37 ? 102 ARG M CA 1 ATOM 774 C C . ARG A 1 102 ? 58.167 111.161 69.943 1.00 7.03 ? 102 ARG M C 1 ATOM 775 O O . ARG A 1 102 ? 58.773 111.180 71.012 1.00 8.75 ? 102 ARG M O 1 ATOM 776 C CB . ARG A 1 102 ? 57.350 113.355 69.058 1.00 6.62 ? 102 ARG M CB 1 ATOM 777 C CG . ARG A 1 102 ? 57.422 114.053 70.419 1.00 7.16 ? 102 ARG M CG 1 ATOM 778 C CD . ARG A 1 102 ? 56.531 115.278 70.469 1.00 6.73 ? 102 ARG M CD 1 ATOM 779 N NE . ARG A 1 102 ? 56.938 116.290 69.496 1.00 7.05 ? 102 ARG M NE 1 ATOM 780 C CZ . ARG A 1 102 ? 58.026 117.048 69.611 1.00 8.05 ? 102 ARG M CZ 1 ATOM 781 N NH1 . ARG A 1 102 ? 58.826 116.918 70.661 1.00 8.13 ? 102 ARG M NH1 1 ATOM 782 N NH2 . ARG A 1 102 ? 58.323 117.930 68.665 1.00 9.07 ? 102 ARG M NH2 1 ATOM 783 N N . ILE A 1 103 ? 57.299 110.200 69.640 1.00 7.74 ? 103 ILE M N 1 ATOM 784 C CA . ILE A 1 103 ? 57.047 109.153 70.621 1.00 8.23 ? 103 ILE M CA 1 ATOM 785 C C . ILE A 1 103 ? 57.877 107.885 70.456 1.00 9.04 ? 103 ILE M C 1 ATOM 786 O O . ILE A 1 103 ? 58.074 107.155 71.418 1.00 9.56 ? 103 ILE M O 1 ATOM 787 C CB . ILE A 1 103 ? 55.545 108.862 70.807 1.00 10.86 ? 103 ILE M CB 1 ATOM 788 C CG1 . ILE A 1 103 ? 54.942 108.240 69.555 1.00 12.85 ? 103 ILE M CG1 1 ATOM 789 C CG2 . ILE A 1 103 ? 54.808 110.161 71.164 1.00 10.57 ? 103 ILE M CG2 1 ATOM 790 C CD1 . ILE A 1 103 ? 53.493 107.806 69.769 1.00 14.09 ? 103 ILE M CD1 1 ATOM 791 N N . ILE A 1 104 ? 58.340 107.616 69.233 1.00 7.78 ? 104 ILE M N 1 ATOM 792 C CA . ILE A 1 104 ? 59.220 106.476 68.961 1.00 8.26 ? 104 ILE M CA 1 ATOM 793 C C . ILE A 1 104 ? 60.284 106.988 67.995 1.00 7.91 ? 104 ILE M C 1 ATOM 794 O O . ILE A 1 104 ? 60.225 106.728 66.787 1.00 8.62 ? 104 ILE M O 1 ATOM 795 C CB . ILE A 1 104 ? 58.519 105.272 68.292 1.00 7.62 ? 104 ILE M CB 1 ATOM 796 C CG1 . ILE A 1 104 ? 57.256 104.875 69.054 1.00 7.08 ? 104 ILE M CG1 1 ATOM 797 C CG2 . ILE A 1 104 ? 59.483 104.081 68.275 1.00 8.86 ? 104 ILE M CG2 1 ATOM 798 C CD1 . ILE A 1 104 ? 56.454 103.774 68.365 1.00 9.51 ? 104 ILE M CD1 1 ATOM 799 N N . PRO A 1 105 ? 61.255 107.755 68.513 1.00 8.04 ? 105 PRO M N 1 ATOM 800 C CA . PRO A 1 105 ? 62.342 108.321 67.710 1.00 7.23 ? 105 PRO M CA 1 ATOM 801 C C . PRO A 1 105 ? 63.083 107.293 66.862 1.00 7.97 ? 105 PRO M C 1 ATOM 802 O O . PRO A 1 105 ? 63.559 107.609 65.771 1.00 9.28 ? 105 PRO M O 1 ATOM 803 C CB . PRO A 1 105 ? 63.254 108.931 68.770 1.00 7.86 ? 105 PRO M CB 1 ATOM 804 C CG . PRO A 1 105 ? 62.293 109.393 69.801 1.00 10.71 ? 105 PRO M CG 1 ATOM 805 C CD . PRO A 1 105 ? 61.342 108.222 69.909 1.00 8.93 ? 105 PRO M CD 1 ATOM 806 N N . ARG A 1 106 ? 63.181 106.065 67.365 1.00 6.55 ? 106 ARG M N 1 ATOM 807 C CA . ARG A 1 106 ? 63.880 105.013 66.636 1.00 6.79 ? 106 ARG M CA 1 ATOM 808 C C . ARG A 1 106 ? 62.996 104.226 65.662 1.00 7.12 ? 106 ARG M C 1 ATOM 809 O O . ARG A 1 106 ? 63.422 103.211 65.111 1.00 8.22 ? 106 ARG M O 1 ATOM 810 C CB . ARG A 1 106 ? 64.612 104.090 67.616 1.00 9.00 ? 106 ARG M CB 1 ATOM 811 C CG . ARG A 1 106 ? 65.684 104.820 68.422 1.00 6.44 ? 106 ARG M CG 1 ATOM 812 C CD . ARG A 1 106 ? 66.391 103.896 69.392 1.00 7.44 ? 106 ARG M CD 1 ATOM 813 N NE . ARG A 1 106 ? 67.113 102.836 68.692 1.00 8.57 ? 106 ARG M NE 1 ATOM 814 C CZ . ARG A 1 106 ? 67.678 101.794 69.290 1.00 9.92 ? 106 ARG M CZ 1 ATOM 815 N NH1 . ARG A 1 106 ? 67.611 101.664 70.610 1.00 11.02 ? 106 ARG M NH1 1 ATOM 816 N NH2 . ARG A 1 106 ? 68.286 100.866 68.563 1.00 10.98 ? 106 ARG M NH2 1 ATOM 817 N N . GLY A 1 107 ? 61.782 104.724 65.429 1.00 6.79 ? 107 GLY M N 1 ATOM 818 C CA . GLY A 1 107 ? 60.866 104.095 64.488 1.00 7.65 ? 107 GLY M CA 1 ATOM 819 C C . GLY A 1 107 ? 60.164 102.830 64.938 1.00 7.27 ? 107 GLY M C 1 ATOM 820 O O . GLY A 1 107 ? 58.937 102.787 65.002 1.00 9.05 ? 107 GLY M O 1 ATOM 821 N N . LYS A 1 108 ? 60.944 101.781 65.180 1.00 8.03 ? 108 LYS M N 1 ATOM 822 C CA . LYS A 1 108 ? 60.416 100.496 65.627 1.00 9.52 ? 108 LYS M CA 1 ATOM 823 C C . LYS A 1 108 ? 60.196 100.556 67.139 1.00 10.44 ? 108 LYS M C 1 ATOM 824 O O . LYS A 1 108 ? 61.123 100.826 67.897 1.00 10.68 ? 108 LYS M O 1 ATOM 825 C CB . LYS A 1 108 ? 61.400 99.380 65.258 1.00 12.05 ? 108 LYS M CB 1 ATOM 826 C CG . LYS A 1 108 ? 60.983 97.987 65.694 1.00 19.34 ? 108 LYS M CG 1 ATOM 827 C CD . LYS A 1 108 ? 61.937 96.936 65.141 1.00 24.25 ? 108 LYS M CD 1 ATOM 828 C CE . LYS A 1 108 ? 61.606 95.540 65.665 1.00 25.88 ? 108 LYS M CE 1 ATOM 829 N NZ . LYS A 1 108 ? 60.189 95.143 65.427 1.00 34.03 ? 108 LYS M NZ 1 ATOM 830 N N . ARG A 1 109 ? 58.968 100.278 67.564 1.00 9.22 ? 109 ARG M N 1 ATOM 831 C CA . ARG A 1 109 ? 58.598 100.339 68.975 1.00 8.65 ? 109 ARG M CA 1 ATOM 832 C C . ARG A 1 109 ? 59.462 99.515 69.932 1.00 9.26 ? 109 ARG M C 1 ATOM 833 O O . ARG A 1 109 ? 59.710 99.936 71.064 1.00 10.15 ? 109 ARG M O 1 ATOM 834 C CB . ARG A 1 109 ? 57.130 99.959 69.137 1.00 9.34 ? 109 ARG M CB 1 ATOM 835 C CG . ARG A 1 109 ? 56.613 100.108 70.550 1.00 10.77 ? 109 ARG M CG 1 ATOM 836 C CD . ARG A 1 109 ? 55.172 99.696 70.593 1.00 15.31 ? 109 ARG M CD 1 ATOM 837 N NE . ARG A 1 109 ? 54.612 99.762 71.935 1.00 16.78 ? 109 ARG M NE 1 ATOM 838 C CZ . ARG A 1 109 ? 53.337 99.519 72.203 1.00 19.30 ? 109 ARG M CZ 1 ATOM 839 N NH1 . ARG A 1 109 ? 52.510 99.202 71.214 1.00 19.35 ? 109 ARG M NH1 1 ATOM 840 N NH2 . ARG A 1 109 ? 52.895 99.583 73.449 1.00 18.46 ? 109 ARG M NH2 1 ATOM 841 N N . SER A 1 110 ? 59.951 98.370 69.469 1.00 11.37 ? 110 SER M N 1 ATOM 842 C CA . SER A 1 110 ? 60.783 97.508 70.307 1.00 12.26 ? 110 SER M CA 1 ATOM 843 C C . SER A 1 110 ? 62.097 98.172 70.707 1.00 13.02 ? 110 SER M C 1 ATOM 844 O O . SER A 1 110 ? 62.764 97.728 71.641 1.00 14.28 ? 110 SER M O 1 ATOM 845 C CB . SER A 1 110 ? 61.068 96.184 69.597 1.00 14.32 ? 110 SER M CB 1 ATOM 846 O OG . SER A 1 110 ? 61.871 96.394 68.452 1.00 17.75 ? 110 SER M OG 1 ATOM 847 N N . ARG A 1 111 ? 62.463 99.234 69.995 1.00 10.72 ? 111 ARG M N 1 ATOM 848 C CA . ARG A 1 111 ? 63.692 99.967 70.277 1.00 10.53 ? 111 ARG M CA 1 ATOM 849 C C . ARG A 1 111 ? 63.520 100.958 71.418 1.00 12.53 ? 111 ARG M C 1 ATOM 850 O O . ARG A 1 111 ? 64.480 101.614 71.833 1.00 13.71 ? 111 ARG M O 1 ATOM 851 C CB . ARG A 1 111 ? 64.177 100.683 69.017 1.00 9.55 ? 111 ARG M CB 1 ATOM 852 C CG . ARG A 1 111 ? 64.554 99.714 67.919 1.00 8.76 ? 111 ARG M CG 1 ATOM 853 C CD . ARG A 1 111 ? 64.878 100.417 66.624 1.00 7.25 ? 111 ARG M CD 1 ATOM 854 N NE . ARG A 1 111 ? 65.247 99.437 65.607 1.00 8.91 ? 111 ARG M NE 1 ATOM 855 C CZ . ARG A 1 111 ? 65.237 99.674 64.301 1.00 11.67 ? 111 ARG M CZ 1 ATOM 856 N NH1 . ARG A 1 111 ? 64.878 100.866 63.842 1.00 10.96 ? 111 ARG M NH1 1 ATOM 857 N NH2 . ARG A 1 111 ? 65.573 98.712 63.453 1.00 12.30 ? 111 ARG M NH2 1 ATOM 858 N N . GLY A 1 112 ? 62.289 101.079 71.906 1.00 10.18 ? 112 GLY M N 1 ATOM 859 C CA . GLY A 1 112 ? 62.018 101.979 73.010 1.00 10.71 ? 112 GLY M CA 1 ATOM 860 C C . GLY A 1 112 ? 61.146 103.154 72.634 1.00 11.68 ? 112 GLY M C 1 ATOM 861 O O . GLY A 1 112 ? 61.058 103.531 71.468 1.00 13.21 ? 112 GLY M O 1 ATOM 862 N N . VAL A 1 113 ? 60.485 103.725 73.631 1.00 11.42 ? 113 VAL M N 1 ATOM 863 C CA . VAL A 1 113 ? 59.616 104.866 73.400 1.00 12.73 ? 113 VAL M CA 1 ATOM 864 C C . VAL A 1 113 ? 60.154 106.085 74.135 1.00 15.10 ? 113 VAL M C 1 ATOM 865 O O . VAL A 1 113 ? 60.970 105.966 75.051 1.00 16.89 ? 113 VAL M O 1 ATOM 866 C CB . VAL A 1 113 ? 58.163 104.574 73.853 1.00 15.06 ? 113 VAL M CB 1 ATOM 867 C CG1 . VAL A 1 113 ? 57.624 103.353 73.122 1.00 18.65 ? 113 VAL M CG1 1 ATOM 868 C CG2 . VAL A 1 113 ? 58.094 104.376 75.359 1.00 20.27 ? 113 VAL M CG2 1 ATOM 869 N N . ASN A 1 114 ? 59.740 107.261 73.686 1.00 11.28 ? 114 ASN M N 1 ATOM 870 C CA . ASN A 1 114 ? 60.155 108.505 74.311 1.00 10.57 ? 114 ASN M CA 1 ATOM 871 C C . ASN A 1 114 ? 59.041 108.919 75.266 1.00 12.94 ? 114 ASN M C 1 ATOM 872 O O . ASN A 1 114 ? 58.028 109.478 74.844 1.00 11.37 ? 114 ASN M O 1 ATOM 873 C CB . ASN A 1 114 ? 60.372 109.581 73.245 1.00 11.14 ? 114 ASN M CB 1 ATOM 874 C CG . ASN A 1 114 ? 60.745 110.927 73.838 1.00 12.05 ? 114 ASN M CG 1 ATOM 875 O OD1 . ASN A 1 114 ? 61.061 111.031 75.024 1.00 12.26 ? 114 ASN M OD1 1 ATOM 876 N ND2 . ASN A 1 114 ? 60.707 111.967 73.012 1.00 11.80 ? 114 ASN M ND2 1 ATOM 877 N N . GLU A 1 115 ? 59.230 108.637 76.552 1.00 11.98 ? 115 GLU M N 1 ATOM 878 C CA . GLU A 1 115 ? 58.225 108.972 77.558 1.00 14.58 ? 115 GLU M CA 1 ATOM 879 C C . GLU A 1 115 ? 57.900 110.465 77.601 1.00 13.07 ? 115 GLU M C 1 ATOM 880 O O . GLU A 1 115 ? 56.752 110.839 77.824 1.00 12.11 ? 115 GLU M O 1 ATOM 881 C CB . GLU A 1 115 ? 58.664 108.478 78.939 1.00 17.22 ? 115 GLU M CB 1 ATOM 882 C CG . GLU A 1 115 ? 57.520 108.328 79.940 1.00 28.28 ? 115 GLU M CG 1 ATOM 883 C CD . GLU A 1 115 ? 56.501 107.259 79.541 1.00 31.41 ? 115 GLU M CD 1 ATOM 884 O OE1 . GLU A 1 115 ? 56.824 106.376 78.714 1.00 35.47 ? 115 GLU M OE1 1 ATOM 885 O OE2 . GLU A 1 115 ? 55.368 107.297 80.066 1.00 37.01 ? 115 GLU M OE2 1 ATOM 886 N N . LYS A 1 116 ? 58.903 111.318 77.394 1.00 11.91 ? 116 LYS M N 1 ATOM 887 C CA . LYS A 1 116 ? 58.664 112.761 77.400 1.00 11.83 ? 116 LYS M CA 1 ATOM 888 C C . LYS A 1 116 ? 57.786 113.152 76.214 1.00 10.15 ? 116 LYS M C 1 ATOM 889 O O . LYS A 1 116 ? 56.955 114.056 76.315 1.00 10.32 ? 116 LYS M O 1 ATOM 890 C CB . LYS A 1 116 ? 59.984 113.540 77.369 1.00 16.00 ? 116 LYS M CB 1 ATOM 891 C CG . LYS A 1 116 ? 60.800 113.421 78.651 1.00 22.00 ? 116 LYS M CG 1 ATOM 892 C CD . LYS A 1 116 ? 59.965 113.774 79.882 1.00 25.53 ? 116 LYS M CD 1 ATOM 893 C CE . LYS A 1 116 ? 59.412 115.191 79.806 1.00 28.26 ? 116 LYS M CE 1 ATOM 894 N NZ . LYS A 1 116 ? 58.446 115.473 80.907 1.00 33.30 ? 116 LYS M NZ 1 ATOM 895 N N . GLY A 1 117 ? 57.954 112.438 75.103 1.00 10.22 ? 117 GLY M N 1 ATOM 896 C CA . GLY A 1 117 ? 57.160 112.701 73.915 1.00 9.66 ? 117 GLY M CA 1 ATOM 897 C C . GLY A 1 117 ? 55.715 112.313 74.154 1.00 10.27 ? 117 GLY M C 1 ATOM 898 O O . GLY A 1 117 ? 54.790 113.010 73.730 1.00 11.33 ? 117 GLY M O 1 ATOM 899 N N . ILE A 1 118 ? 55.523 111.185 74.833 1.00 9.22 ? 118 ILE M N 1 ATOM 900 C CA . ILE A 1 118 ? 54.189 110.701 75.158 1.00 10.62 ? 118 ILE M CA 1 ATOM 901 C C . ILE A 1 118 ? 53.519 111.711 76.090 1.00 9.82 ? 118 ILE M C 1 ATOM 902 O O . ILE A 1 118 ? 52.356 112.063 75.896 1.00 10.46 ? 118 ILE M O 1 ATOM 903 C CB . ILE A 1 118 ? 54.252 109.306 75.815 1.00 10.82 ? 118 ILE M CB 1 ATOM 904 C CG1 . ILE A 1 118 ? 54.728 108.274 74.787 1.00 13.33 ? 118 ILE M CG1 1 ATOM 905 C CG2 . ILE A 1 118 ? 52.886 108.909 76.366 1.00 13.51 ? 118 ILE M CG2 1 ATOM 906 C CD1 . ILE A 1 118 ? 55.001 106.905 75.369 1.00 15.25 ? 118 ILE M CD1 1 ATOM 907 N N . ASP A 1 119 ? 54.286 112.232 77.048 1.00 10.76 ? 119 ASP M N 1 ATOM 908 C CA . ASP A 1 119 ? 53.778 113.225 77.994 1.00 11.49 ? 119 ASP M CA 1 ATOM 909 C C . ASP A 1 119 ? 53.341 114.502 77.285 1.00 10.08 ? 119 ASP M C 1 ATOM 910 O O . ASP A 1 119 ? 52.377 115.150 77.696 1.00 9.82 ? 119 ASP M O 1 ATOM 911 C CB . ASP A 1 119 ? 54.837 113.567 79.047 1.00 16.08 ? 119 ASP M CB 1 ATOM 912 C CG . ASP A 1 119 ? 54.996 112.484 80.099 1.00 23.65 ? 119 ASP M CG 1 ATOM 913 O OD1 . ASP A 1 119 ? 54.005 111.784 80.399 1.00 31.26 ? 119 ASP M OD1 1 ATOM 914 O OD2 . ASP A 1 119 ? 56.112 112.346 80.644 1.00 29.59 ? 119 ASP M OD2 1 ATOM 915 N N . TYR A 1 120 ? 54.072 114.883 76.239 1.00 9.65 ? 120 TYR M N 1 ATOM 916 C CA . TYR A 1 120 ? 53.732 116.079 75.478 1.00 9.22 ? 120 TYR M CA 1 ATOM 917 C C . TYR A 1 120 ? 52.293 115.993 74.960 1.00 9.59 ? 120 TYR M C 1 ATOM 918 O O . TYR A 1 120 ? 51.503 116.914 75.156 1.00 9.55 ? 120 TYR M O 1 ATOM 919 C CB . TYR A 1 120 ? 54.711 116.273 74.312 1.00 9.64 ? 120 TYR M CB 1 ATOM 920 C CG . TYR A 1 120 ? 54.295 117.364 73.348 1.00 11.94 ? 120 TYR M CG 1 ATOM 921 C CD1 . TYR A 1 120 ? 54.412 118.713 73.688 1.00 15.84 ? 120 TYR M CD1 1 ATOM 922 C CD2 . TYR A 1 120 ? 53.742 117.046 72.112 1.00 12.12 ? 120 TYR M CD2 1 ATOM 923 C CE1 . TYR A 1 120 ? 53.982 119.717 72.813 1.00 15.36 ? 120 TYR M CE1 1 ATOM 924 C CE2 . TYR A 1 120 ? 53.312 118.036 71.233 1.00 14.78 ? 120 TYR M CE2 1 ATOM 925 C CZ . TYR A 1 120 ? 53.431 119.367 71.588 1.00 17.80 ? 120 TYR M CZ 1 ATOM 926 O OH . TYR A 1 120 ? 52.993 120.342 70.717 1.00 18.27 ? 120 TYR M OH 1 ATOM 927 N N . TYR A 1 121 ? 51.945 114.864 74.346 1.00 7.96 ? 121 TYR M N 1 ATOM 928 C CA . TYR A 1 121 ? 50.599 114.685 73.816 1.00 7.23 ? 121 TYR M CA 1 ATOM 929 C C . TYR A 1 121 ? 49.557 114.505 74.915 1.00 8.95 ? 121 TYR M C 1 ATOM 930 O O . TYR A 1 121 ? 48.427 114.958 74.774 1.00 8.90 ? 121 TYR M O 1 ATOM 931 C CB . TYR A 1 121 ? 50.563 113.547 72.793 1.00 8.94 ? 121 TYR M CB 1 ATOM 932 C CG . TYR A 1 121 ? 51.377 113.870 71.565 1.00 7.92 ? 121 TYR M CG 1 ATOM 933 C CD1 . TYR A 1 121 ? 51.000 114.911 70.713 1.00 7.38 ? 121 TYR M CD1 1 ATOM 934 C CD2 . TYR A 1 121 ? 52.561 113.186 71.290 1.00 7.45 ? 121 TYR M CD2 1 ATOM 935 C CE1 . TYR A 1 121 ? 51.789 115.269 69.620 1.00 6.82 ? 121 TYR M CE1 1 ATOM 936 C CE2 . TYR A 1 121 ? 53.353 113.534 70.205 1.00 7.02 ? 121 TYR M CE2 1 ATOM 937 C CZ . TYR A 1 121 ? 52.966 114.575 69.381 1.00 6.21 ? 121 TYR M CZ 1 ATOM 938 O OH . TYR A 1 121 ? 53.773 114.931 68.334 1.00 6.67 ? 121 TYR M OH 1 ATOM 939 N N . HIS A 1 122 ? 49.943 113.879 76.023 1.00 10.75 ? 122 HIS M N 1 ATOM 940 C CA . HIS A 1 122 ? 49.017 113.712 77.143 1.00 12.68 ? 122 HIS M CA 1 ATOM 941 C C . HIS A 1 122 ? 48.561 115.085 77.633 1.00 12.61 ? 122 HIS M C 1 ATOM 942 O O . HIS A 1 122 ? 47.372 115.302 77.888 1.00 12.87 ? 122 HIS M O 1 ATOM 943 C CB . HIS A 1 122 ? 49.686 112.975 78.306 1.00 13.95 ? 122 HIS M CB 1 ATOM 944 C CG . HIS A 1 122 ? 49.637 111.488 78.191 1.00 18.36 ? 122 HIS M CG 1 ATOM 945 N ND1 . HIS A 1 122 ? 48.481 110.802 77.886 1.00 18.12 ? 122 HIS M ND1 1 ATOM 946 C CD2 . HIS A 1 122 ? 50.594 110.545 78.370 1.00 17.74 ? 122 HIS M CD2 1 ATOM 947 C CE1 . HIS A 1 122 ? 48.727 109.506 77.882 1.00 19.86 ? 122 HIS M CE1 1 ATOM 948 N NE2 . HIS A 1 122 ? 50.005 109.323 78.173 1.00 19.61 ? 122 HIS M NE2 1 ATOM 949 N N . GLY A 1 123 ? 49.518 116.004 77.761 1.00 10.44 ? 123 GLY M N 1 ATOM 950 C CA . GLY A 1 123 ? 49.218 117.347 78.224 1.00 11.39 ? 123 GLY M CA 1 ATOM 951 C C . GLY A 1 123 ? 48.319 118.094 77.260 1.00 10.69 ? 123 GLY M C 1 ATOM 952 O O . GLY A 1 123 ? 47.366 118.756 77.671 1.00 10.13 ? 123 GLY M O 1 ATOM 953 N N . LEU A 1 124 ? 48.601 117.957 75.968 1.00 8.85 ? 124 LEU M N 1 ATOM 954 C CA . LEU A 1 124 ? 47.803 118.626 74.950 1.00 10.01 ? 124 LEU M CA 1 ATOM 955 C C . LEU A 1 124 ? 46.369 118.107 74.956 1.00 8.60 ? 124 LEU M C 1 ATOM 956 O O . LEU A 1 124 ? 45.419 118.888 74.984 1.00 10.35 ? 124 LEU M O 1 ATOM 957 C CB . LEU A 1 124 ? 48.426 118.433 73.564 1.00 9.36 ? 124 LEU M CB 1 ATOM 958 C CG . LEU A 1 124 ? 47.582 118.926 72.384 1.00 10.78 ? 124 LEU M CG 1 ATOM 959 C CD1 . LEU A 1 124 ? 47.286 120.416 72.508 1.00 11.78 ? 124 LEU M CD1 1 ATOM 960 C CD2 . LEU A 1 124 ? 48.300 118.621 71.084 1.00 8.55 ? 124 LEU M CD2 1 ATOM 961 N N . ILE A 1 125 ? 46.227 116.786 74.959 1.00 7.98 ? 125 ILE M N 1 ATOM 962 C CA . ILE A 1 125 ? 44.918 116.148 74.956 1.00 9.40 ? 125 ILE M CA 1 ATOM 963 C C . ILE A 1 125 ? 44.123 116.517 76.209 1.00 10.83 ? 125 ILE M C 1 ATOM 964 O O . ILE A 1 125 ? 42.943 116.869 76.122 1.00 11.08 ? 125 ILE M O 1 ATOM 965 C CB . ILE A 1 125 ? 45.055 114.616 74.821 1.00 10.14 ? 125 ILE M CB 1 ATOM 966 C CG1 . ILE A 1 125 ? 45.626 114.275 73.437 1.00 9.20 ? 125 ILE M CG1 1 ATOM 967 C CG2 . ILE A 1 125 ? 43.704 113.943 75.017 1.00 11.16 ? 125 ILE M CG2 1 ATOM 968 C CD1 . ILE A 1 125 ? 46.172 112.866 73.322 1.00 12.75 ? 125 ILE M CD1 1 ATOM 969 N N . SER A 1 126 ? 44.784 116.481 77.362 1.00 10.84 ? 126 SER M N 1 ATOM 970 C CA . SER A 1 126 ? 44.133 116.820 78.626 1.00 13.88 ? 126 SER M CA 1 ATOM 971 C C . SER A 1 126 ? 43.636 118.263 78.596 1.00 14.02 ? 126 SER M C 1 ATOM 972 O O . SER A 1 126 ? 42.523 118.553 79.036 1.00 12.85 ? 126 SER M O 1 ATOM 973 C CB . SER A 1 126 ? 45.102 116.629 79.796 1.00 16.08 ? 126 SER M CB 1 ATOM 974 O OG . SER A 1 126 ? 44.485 116.949 81.033 1.00 28.71 ? 126 SER M OG 1 ATOM 975 N N . GLY A 1 127 ? 44.463 119.154 78.053 1.00 11.35 ? 127 GLY M N 1 ATOM 976 C CA . GLY A 1 127 ? 44.103 120.558 77.963 1.00 12.63 ? 127 GLY M CA 1 ATOM 977 C C . GLY A 1 127 ? 42.941 120.826 77.025 1.00 13.06 ? 127 GLY M C 1 ATOM 978 O O . GLY A 1 127 ? 42.112 121.697 77.291 1.00 13.04 ? 127 GLY M O 1 ATOM 979 N N . LEU A 1 128 ? 42.876 120.083 75.923 1.00 9.52 ? 128 LEU M N 1 ATOM 980 C CA . LEU A 1 128 ? 41.794 120.244 74.957 1.00 9.07 ? 128 LEU M CA 1 ATOM 981 C C . LEU A 1 128 ? 40.467 119.806 75.564 1.00 10.35 ? 128 LEU M C 1 ATOM 982 O O . LEU A 1 128 ? 39.465 120.514 75.479 1.00 11.68 ? 128 LEU M O 1 ATOM 983 C CB . LEU A 1 128 ? 42.073 119.404 73.708 1.00 9.98 ? 128 LEU M CB 1 ATOM 984 C CG . LEU A 1 128 ? 43.232 119.867 72.830 1.00 9.11 ? 128 LEU M CG 1 ATOM 985 C CD1 . LEU A 1 128 ? 43.567 118.785 71.812 1.00 9.45 ? 128 LEU M CD1 1 ATOM 986 C CD2 . LEU A 1 128 ? 42.860 121.172 72.150 1.00 10.69 ? 128 LEU M CD2 1 ATOM 987 N N . ILE A 1 129 ? 40.476 118.632 76.184 1.00 11.96 ? 129 ILE M N 1 ATOM 988 C CA . ILE A 1 129 ? 39.274 118.080 76.797 1.00 14.12 ? 129 ILE M CA 1 ATOM 989 C C . ILE A 1 129 ? 38.749 118.981 77.910 1.00 16.13 ? 129 ILE M C 1 ATOM 990 O O . ILE A 1 129 ? 37.537 119.170 78.042 1.00 16.19 ? 129 ILE M O 1 ATOM 991 C CB . ILE A 1 129 ? 39.535 116.651 77.306 1.00 16.36 ? 129 ILE M CB 1 ATOM 992 C CG1 . ILE A 1 129 ? 39.741 115.725 76.104 1.00 16.82 ? 129 ILE M CG1 1 ATOM 993 C CG2 . ILE A 1 129 ? 38.371 116.154 78.162 1.00 21.75 ? 129 ILE M CG2 1 ATOM 994 C CD1 . ILE A 1 129 ? 40.155 114.336 76.470 1.00 21.35 ? 129 ILE M CD1 1 ATOM 995 N N . LYS A 1 130 ? 39.663 119.575 78.672 1.00 15.89 ? 130 LYS M N 1 ATOM 996 C CA . LYS A 1 130 ? 39.281 120.469 79.762 1.00 18.38 ? 130 LYS M CA 1 ATOM 997 C C . LYS A 1 130 ? 38.562 121.720 79.265 1.00 19.99 ? 130 LYS M C 1 ATOM 998 O O . LYS A 1 130 ? 37.827 122.363 80.017 1.00 19.29 ? 130 LYS M O 1 ATOM 999 C CB . LYS A 1 130 ? 40.501 120.845 80.599 1.00 22.40 ? 130 LYS M CB 1 ATOM 1000 C CG . LYS A 1 130 ? 40.975 119.713 81.495 1.00 27.54 ? 130 LYS M CG 1 ATOM 1001 C CD . LYS A 1 130 ? 42.233 120.081 82.256 1.00 32.82 ? 130 LYS M CD 1 ATOM 1002 C CE . LYS A 1 130 ? 42.670 118.938 83.159 1.00 35.81 ? 130 LYS M CE 1 ATOM 1003 N NZ . LYS A 1 130 ? 43.915 119.261 83.910 1.00 39.00 ? 130 LYS M NZ 1 ATOM 1004 N N . LYS A 1 131 ? 38.769 122.053 77.994 1.00 17.15 ? 131 LYS M N 1 ATOM 1005 C CA . LYS A 1 131 ? 38.125 123.213 77.387 1.00 17.41 ? 131 LYS M CA 1 ATOM 1006 C C . LYS A 1 131 ? 36.945 122.806 76.500 1.00 16.65 ? 131 LYS M C 1 ATOM 1007 O O . LYS A 1 131 ? 36.439 123.612 75.718 1.00 17.60 ? 131 LYS M O 1 ATOM 1008 C CB . LYS A 1 131 ? 39.141 124.037 76.592 1.00 18.59 ? 131 LYS M CB 1 ATOM 1009 C CG . LYS A 1 131 ? 40.111 124.822 77.463 1.00 18.76 ? 131 LYS M CG 1 ATOM 1010 C CD . LYS A 1 131 ? 39.357 125.797 78.357 1.00 25.62 ? 131 LYS M CD 1 ATOM 1011 C CE . LYS A 1 131 ? 40.296 126.577 79.261 1.00 27.96 ? 131 LYS M CE 1 ATOM 1012 N NZ . LYS A 1 131 ? 39.538 127.516 80.138 1.00 30.94 ? 131 LYS M NZ 1 ATOM 1013 N N . GLY A 1 132 ? 36.521 121.550 76.626 1.00 14.66 ? 132 GLY M N 1 ATOM 1014 C CA . GLY A 1 132 ? 35.400 121.044 75.851 1.00 13.68 ? 132 GLY M CA 1 ATOM 1015 C C . GLY A 1 132 ? 35.668 120.900 74.365 1.00 14.16 ? 132 GLY M C 1 ATOM 1016 O O . GLY A 1 132 ? 34.757 121.018 73.548 1.00 14.43 ? 132 GLY M O 1 ATOM 1017 N N . ILE A 1 133 ? 36.922 120.636 74.016 1.00 11.43 ? 133 ILE M N 1 ATOM 1018 C CA . ILE A 1 133 ? 37.314 120.477 72.620 1.00 10.39 ? 133 ILE M CA 1 ATOM 1019 C C . ILE A 1 133 ? 37.564 119.007 72.318 1.00 11.92 ? 133 ILE M C 1 ATOM 1020 O O . ILE A 1 133 ? 38.358 118.360 72.998 1.00 14.18 ? 133 ILE M O 1 ATOM 1021 C CB . ILE A 1 133 ? 38.597 121.279 72.322 1.00 9.10 ? 133 ILE M CB 1 ATOM 1022 C CG1 . ILE A 1 133 ? 38.388 122.746 72.697 1.00 11.50 ? 133 ILE M CG1 1 ATOM 1023 C CG2 . ILE A 1 133 ? 38.971 121.156 70.849 1.00 11.87 ? 133 ILE M CG2 1 ATOM 1024 C CD1 . ILE A 1 133 ? 39.674 123.513 72.887 1.00 11.61 ? 133 ILE M CD1 1 ATOM 1025 N N . THR A 1 134 ? 36.879 118.492 71.299 1.00 9.04 ? 134 THR M N 1 ATOM 1026 C CA . THR A 1 134 ? 37.016 117.099 70.889 1.00 10.69 ? 134 THR M CA 1 ATOM 1027 C C . THR A 1 134 ? 38.235 116.922 69.989 1.00 10.12 ? 134 THR M C 1 ATOM 1028 O O . THR A 1 134 ? 38.323 117.541 68.929 1.00 9.94 ? 134 THR M O 1 ATOM 1029 C CB . THR A 1 134 ? 35.772 116.628 70.106 1.00 12.45 ? 134 THR M CB 1 ATOM 1030 O OG1 . THR A 1 134 ? 34.606 116.752 70.931 1.00 13.55 ? 134 THR M OG1 1 ATOM 1031 C CG2 . THR A 1 134 ? 35.924 115.172 69.673 1.00 13.09 ? 134 THR M CG2 1 ATOM 1032 N N . PRO A 1 135 ? 39.198 116.087 70.410 1.00 9.34 ? 135 PRO M N 1 ATOM 1033 C CA . PRO A 1 135 ? 40.394 115.861 69.595 1.00 8.66 ? 135 PRO M CA 1 ATOM 1034 C C . PRO A 1 135 ? 40.141 114.889 68.440 1.00 10.20 ? 135 PRO M C 1 ATOM 1035 O O . PRO A 1 135 ? 39.421 113.899 68.597 1.00 10.66 ? 135 PRO M O 1 ATOM 1036 C CB . PRO A 1 135 ? 41.379 115.226 70.585 1.00 10.81 ? 135 PRO M CB 1 ATOM 1037 C CG . PRO A 1 135 ? 40.830 115.580 71.950 1.00 14.08 ? 135 PRO M CG 1 ATOM 1038 C CD . PRO A 1 135 ? 39.352 115.487 71.744 1.00 10.34 ? 135 PRO M CD 1 ATOM 1039 N N . PHE A 1 136 ? 40.694 115.220 67.276 1.00 8.66 ? 136 PHE M N 1 ATOM 1040 C CA . PHE A 1 136 ? 40.641 114.373 66.082 1.00 7.73 ? 136 PHE M CA 1 ATOM 1041 C C . PHE A 1 136 ? 42.132 114.212 65.829 1.00 7.61 ? 136 PHE M C 1 ATOM 1042 O O . PHE A 1 136 ? 42.801 115.159 65.427 1.00 9.74 ? 136 PHE M O 1 ATOM 1043 C CB . PHE A 1 136 ? 39.970 115.086 64.908 1.00 6.46 ? 136 PHE M CB 1 ATOM 1044 C CG . PHE A 1 136 ? 38.480 115.160 65.025 1.00 8.23 ? 136 PHE M CG 1 ATOM 1045 C CD1 . PHE A 1 136 ? 37.881 116.042 65.918 1.00 9.91 ? 136 PHE M CD1 1 ATOM 1046 C CD2 . PHE A 1 136 ? 37.672 114.321 64.265 1.00 9.69 ? 136 PHE M CD2 1 ATOM 1047 C CE1 . PHE A 1 136 ? 36.495 116.081 66.059 1.00 10.80 ? 136 PHE M CE1 1 ATOM 1048 C CE2 . PHE A 1 136 ? 36.285 114.353 64.402 1.00 8.57 ? 136 PHE M CE2 1 ATOM 1049 C CZ . PHE A 1 136 ? 35.698 115.232 65.295 1.00 11.05 ? 136 PHE M CZ 1 ATOM 1050 N N . VAL A 1 137 ? 42.655 113.023 66.104 1.00 6.46 ? 137 VAL M N 1 ATOM 1051 C CA . VAL A 1 137 ? 44.088 112.793 65.992 1.00 6.60 ? 137 VAL M CA 1 ATOM 1052 C C . VAL A 1 137 ? 44.566 111.973 64.805 1.00 7.34 ? 137 VAL M C 1 ATOM 1053 O O . VAL A 1 137 ? 44.150 110.829 64.607 1.00 7.99 ? 137 VAL M O 1 ATOM 1054 C CB . VAL A 1 137 ? 44.623 112.157 67.296 1.00 7.00 ? 137 VAL M CB 1 ATOM 1055 C CG1 . VAL A 1 137 ? 46.135 112.004 67.234 1.00 9.64 ? 137 VAL M CG1 1 ATOM 1056 C CG2 . VAL A 1 137 ? 44.213 113.001 68.500 1.00 8.41 ? 137 VAL M CG2 1 ATOM 1057 N N . THR A 1 138 ? 45.451 112.581 64.021 1.00 7.53 ? 138 THR M N 1 ATOM 1058 C CA . THR A 1 138 ? 46.037 111.929 62.856 1.00 5.95 ? 138 THR M CA 1 ATOM 1059 C C . THR A 1 138 ? 47.288 111.185 63.315 1.00 5.85 ? 138 THR M C 1 ATOM 1060 O O . THR A 1 138 ? 48.198 111.783 63.887 1.00 7.38 ? 138 THR M O 1 ATOM 1061 C CB . THR A 1 138 ? 46.451 112.963 61.789 1.00 7.26 ? 138 THR M CB 1 ATOM 1062 O OG1 . THR A 1 138 ? 45.346 113.828 61.501 1.00 8.72 ? 138 THR M OG1 1 ATOM 1063 C CG2 . THR A 1 138 ? 46.899 112.262 60.509 1.00 7.60 ? 138 THR M CG2 1 ATOM 1064 N N . LEU A 1 139 ? 47.323 109.878 63.082 1.00 6.23 ? 139 LEU M N 1 ATOM 1065 C CA . LEU A 1 139 ? 48.477 109.066 63.467 1.00 7.11 ? 139 LEU M CA 1 ATOM 1066 C C . LEU A 1 139 ? 49.674 109.352 62.571 1.00 7.99 ? 139 LEU M C 1 ATOM 1067 O O . LEU A 1 139 ? 50.810 109.446 63.033 1.00 8.18 ? 139 LEU M O 1 ATOM 1068 C CB . LEU A 1 139 ? 48.135 107.579 63.354 1.00 7.84 ? 139 LEU M CB 1 ATOM 1069 C CG . LEU A 1 139 ? 47.117 107.047 64.357 1.00 8.58 ? 139 LEU M CG 1 ATOM 1070 C CD1 . LEU A 1 139 ? 46.682 105.640 63.964 1.00 10.13 ? 139 LEU M CD1 1 ATOM 1071 C CD2 . LEU A 1 139 ? 47.728 107.055 65.746 1.00 10.92 ? 139 LEU M CD2 1 ATOM 1072 N N . PHE A 1 140 ? 49.415 109.522 61.283 1.00 6.86 ? 140 PHE M N 1 ATOM 1073 C CA . PHE A 1 140 ? 50.508 109.744 60.358 1.00 7.75 ? 140 PHE M CA 1 ATOM 1074 C C . PHE A 1 140 ? 50.254 110.860 59.372 1.00 7.81 ? 140 PHE M C 1 ATOM 1075 O O . PHE A 1 140 ? 49.514 110.684 58.397 1.00 8.49 ? 140 PHE M O 1 ATOM 1076 C CB . PHE A 1 140 ? 50.820 108.443 59.608 1.00 7.39 ? 140 PHE M CB 1 ATOM 1077 C CG . PHE A 1 140 ? 51.970 108.551 58.651 1.00 7.39 ? 140 PHE M CG 1 ATOM 1078 C CD1 . PHE A 1 140 ? 53.269 108.701 59.124 1.00 9.47 ? 140 PHE M CD1 1 ATOM 1079 C CD2 . PHE A 1 140 ? 51.754 108.523 57.275 1.00 10.14 ? 140 PHE M CD2 1 ATOM 1080 C CE1 . PHE A 1 140 ? 54.340 108.812 58.237 1.00 8.41 ? 140 PHE M CE1 1 ATOM 1081 C CE2 . PHE A 1 140 ? 52.819 108.632 56.377 1.00 10.38 ? 140 PHE M CE2 1 ATOM 1082 C CZ . PHE A 1 140 ? 54.115 108.782 56.862 1.00 9.84 ? 140 PHE M CZ 1 ATOM 1083 N N . HIS A 1 141 ? 50.864 112.011 59.636 1.00 5.41 ? 141 HIS M N 1 ATOM 1084 C CA . HIS A 1 141 ? 50.737 113.147 58.739 1.00 5.58 ? 141 HIS M CA 1 ATOM 1085 C C . HIS A 1 141 ? 52.056 113.351 57.978 1.00 8.10 ? 141 HIS M C 1 ATOM 1086 O O . HIS A 1 141 ? 52.691 114.406 58.061 1.00 8.05 ? 141 HIS M O 1 ATOM 1087 C CB . HIS A 1 141 ? 50.315 114.409 59.497 1.00 7.01 ? 141 HIS M CB 1 ATOM 1088 C CG . HIS A 1 141 ? 49.643 115.436 58.636 1.00 8.53 ? 141 HIS M CG 1 ATOM 1089 N ND1 . HIS A 1 141 ? 48.350 115.857 58.854 1.00 8.52 ? 141 HIS M ND1 1 ATOM 1090 C CD2 . HIS A 1 141 ? 50.095 116.143 57.572 1.00 8.78 ? 141 HIS M CD2 1 ATOM 1091 C CE1 . HIS A 1 141 ? 48.033 116.784 57.964 1.00 6.31 ? 141 HIS M CE1 1 ATOM 1092 N NE2 . HIS A 1 141 ? 49.075 116.974 57.177 1.00 8.44 ? 141 HIS M NE2 1 ATOM 1093 N N . TRP A 1 142 ? 52.482 112.282 57.302 1.00 7.51 ? 142 TRP M N 1 ATOM 1094 C CA . TRP A 1 142 ? 53.670 112.249 56.439 1.00 8.21 ? 142 TRP M CA 1 ATOM 1095 C C . TRP A 1 142 ? 55.063 112.230 57.051 1.00 8.05 ? 142 TRP M C 1 ATOM 1096 O O . TRP A 1 142 ? 56.038 111.942 56.350 1.00 8.63 ? 142 TRP M O 1 ATOM 1097 C CB . TRP A 1 142 ? 53.623 113.394 55.423 1.00 9.62 ? 142 TRP M CB 1 ATOM 1098 C CG . TRP A 1 142 ? 52.347 113.493 54.645 1.00 9.60 ? 142 TRP M CG 1 ATOM 1099 C CD1 . TRP A 1 142 ? 51.349 112.567 54.567 1.00 9.33 ? 142 TRP M CD1 1 ATOM 1100 C CD2 . TRP A 1 142 ? 51.942 114.595 53.827 1.00 9.18 ? 142 TRP M CD2 1 ATOM 1101 N NE1 . TRP A 1 142 ? 50.343 113.026 53.747 1.00 9.48 ? 142 TRP M NE1 1 ATOM 1102 C CE2 . TRP A 1 142 ? 50.682 114.262 53.281 1.00 9.57 ? 142 TRP M CE2 1 ATOM 1103 C CE3 . TRP A 1 142 ? 52.525 115.822 53.501 1.00 10.22 ? 142 TRP M CE3 1 ATOM 1104 C CZ2 . TRP A 1 142 ? 49.992 115.131 52.425 1.00 9.58 ? 142 TRP M CZ2 1 ATOM 1105 C CZ3 . TRP A 1 142 ? 51.838 116.681 52.649 1.00 12.82 ? 142 TRP M CZ3 1 ATOM 1106 C CH2 . TRP A 1 142 ? 50.585 116.327 52.119 1.00 13.09 ? 142 TRP M CH2 1 ATOM 1107 N N . ASP A 1 143 ? 55.164 112.548 58.334 1.00 7.60 ? 143 ASP M N 1 ATOM 1108 C CA . ASP A 1 143 ? 56.454 112.606 59.016 1.00 7.88 ? 143 ASP M CA 1 ATOM 1109 C C . ASP A 1 143 ? 56.995 111.261 59.506 1.00 7.53 ? 143 ASP M C 1 ATOM 1110 O O . ASP A 1 143 ? 57.113 111.011 60.705 1.00 8.82 ? 143 ASP M O 1 ATOM 1111 C CB . ASP A 1 143 ? 56.389 113.634 60.155 1.00 8.56 ? 143 ASP M CB 1 ATOM 1112 C CG . ASP A 1 143 ? 55.226 113.398 61.113 1.00 11.34 ? 143 ASP M CG 1 ATOM 1113 O OD1 . ASP A 1 143 ? 54.219 112.767 60.730 1.00 9.98 ? 143 ASP M OD1 1 ATOM 1114 O OD2 . ASP A 1 143 ? 55.319 113.869 62.266 1.00 10.99 ? 143 ASP M OD2 1 ATOM 1115 N N . LEU A 1 144 ? 57.355 110.404 58.558 1.00 7.46 ? 144 LEU M N 1 ATOM 1116 C CA . LEU A 1 144 ? 57.887 109.081 58.864 1.00 7.57 ? 144 LEU M CA 1 ATOM 1117 C C . LEU A 1 144 ? 59.307 109.158 59.425 1.00 5.01 ? 144 LEU M C 1 ATOM 1118 O O . LEU A 1 144 ? 60.154 109.843 58.865 1.00 7.91 ? 144 LEU M O 1 ATOM 1119 C CB . LEU A 1 144 ? 57.939 108.249 57.581 1.00 6.30 ? 144 LEU M CB 1 ATOM 1120 C CG . LEU A 1 144 ? 58.393 106.798 57.763 1.00 8.41 ? 144 LEU M CG 1 ATOM 1121 C CD1 . LEU A 1 144 ? 57.244 105.990 58.339 1.00 9.44 ? 144 LEU M CD1 1 ATOM 1122 C CD2 . LEU A 1 144 ? 58.811 106.219 56.419 1.00 9.22 ? 144 LEU M CD2 1 ATOM 1123 N N . PRO A 1 145 ? 59.588 108.448 60.529 1.00 5.74 ? 145 PRO M N 1 ATOM 1124 C CA . PRO A 1 145 ? 60.937 108.466 61.110 1.00 6.40 ? 145 PRO M CA 1 ATOM 1125 C C . PRO A 1 145 ? 61.961 108.148 60.015 1.00 8.69 ? 145 PRO M C 1 ATOM 1126 O O . PRO A 1 145 ? 61.789 107.191 59.247 1.00 6.82 ? 145 PRO M O 1 ATOM 1127 C CB . PRO A 1 145 ? 60.866 107.350 62.145 1.00 7.16 ? 145 PRO M CB 1 ATOM 1128 C CG . PRO A 1 145 ? 59.473 107.478 62.644 1.00 8.05 ? 145 PRO M CG 1 ATOM 1129 C CD . PRO A 1 145 ? 58.668 107.659 61.367 1.00 5.95 ? 145 PRO M CD 1 ATOM 1130 N N . GLN A 1 146 ? 63.013 108.958 59.938 1.00 6.99 ? 146 GLN M N 1 ATOM 1131 C CA . GLN A 1 146 ? 64.036 108.795 58.905 1.00 7.53 ? 146 GLN M CA 1 ATOM 1132 C C . GLN A 1 146 ? 64.655 107.408 58.886 1.00 6.82 ? 146 GLN M C 1 ATOM 1133 O O . GLN A 1 146 ? 64.944 106.864 57.819 1.00 6.27 ? 146 GLN M O 1 ATOM 1134 C CB . GLN A 1 146 ? 65.131 109.853 59.065 1.00 7.76 ? 146 GLN M CB 1 ATOM 1135 C CG . GLN A 1 146 ? 66.182 109.850 57.943 1.00 9.19 ? 146 GLN M CG 1 ATOM 1136 C CD . GLN A 1 146 ? 65.593 110.197 56.583 1.00 11.79 ? 146 GLN M CD 1 ATOM 1137 O OE1 . GLN A 1 146 ? 64.897 111.204 56.431 1.00 13.14 ? 146 GLN M OE1 1 ATOM 1138 N NE2 . GLN A 1 146 ? 65.852 109.353 55.592 1.00 10.25 ? 146 GLN M NE2 1 ATOM 1139 N N . THR A 1 147 ? 64.839 106.832 60.070 1.00 7.95 ? 147 THR M N 1 ATOM 1140 C CA . THR A 1 147 ? 65.420 105.499 60.190 1.00 8.20 ? 147 THR M CA 1 ATOM 1141 C C . THR A 1 147 ? 64.658 104.453 59.372 1.00 8.79 ? 147 THR M C 1 ATOM 1142 O O . THR A 1 147 ? 65.272 103.597 58.744 1.00 7.21 ? 147 THR M O 1 ATOM 1143 C CB . THR A 1 147 ? 65.503 105.068 61.672 1.00 9.74 ? 147 THR M CB 1 ATOM 1144 O OG1 . THR A 1 147 ? 66.068 103.749 61.767 1.00 16.36 ? 147 THR M OG1 1 ATOM 1145 C CG2 . THR A 1 147 ? 64.121 105.095 62.327 1.00 10.66 ? 147 THR M CG2 1 ATOM 1146 N N . LEU A 1 148 ? 63.328 104.548 59.343 1.00 7.77 ? 148 LEU M N 1 ATOM 1147 C CA . LEU A 1 148 ? 62.527 103.586 58.586 1.00 8.18 ? 148 LEU M CA 1 ATOM 1148 C C . LEU A 1 148 ? 62.682 103.781 57.083 1.00 8.22 ? 148 LEU M C 1 ATOM 1149 O O . LEU A 1 148 ? 62.656 102.814 56.314 1.00 7.91 ? 148 LEU M O 1 ATOM 1150 C CB . LEU A 1 148 ? 61.054 103.649 59.009 1.00 7.48 ? 148 LEU M CB 1 ATOM 1151 C CG . LEU A 1 148 ? 60.824 103.431 60.509 1.00 6.46 ? 148 LEU M CG 1 ATOM 1152 C CD1 . LEU A 1 148 ? 59.335 103.489 60.808 1.00 9.70 ? 148 LEU M CD1 1 ATOM 1153 C CD2 . LEU A 1 148 ? 61.407 102.093 60.959 1.00 7.54 ? 148 LEU M CD2 1 ATOM 1154 N N . GLN A 1 149 ? 62.829 105.031 56.656 1.00 6.71 ? 149 GLN M N 1 ATOM 1155 C CA . GLN A 1 149 ? 63.027 105.301 55.243 1.00 6.15 ? 149 GLN M CA 1 ATOM 1156 C C . GLN A 1 149 ? 64.420 104.807 54.847 1.00 7.30 ? 149 GLN M C 1 ATOM 1157 O O . GLN A 1 149 ? 64.623 104.310 53.743 1.00 7.40 ? 149 GLN M O 1 ATOM 1158 C CB . GLN A 1 149 ? 62.912 106.793 54.950 1.00 6.77 ? 149 GLN M CB 1 ATOM 1159 C CG . GLN A 1 149 ? 62.772 107.108 53.465 1.00 6.29 ? 149 GLN M CG 1 ATOM 1160 C CD . GLN A 1 149 ? 61.424 106.688 52.917 1.00 5.32 ? 149 GLN M CD 1 ATOM 1161 O OE1 . GLN A 1 149 ? 60.401 106.856 53.573 1.00 6.91 ? 149 GLN M OE1 1 ATOM 1162 N NE2 . GLN A 1 149 ? 61.417 106.141 51.705 1.00 6.17 ? 149 GLN M NE2 1 ATOM 1163 N N . ASP A 1 150 ? 65.382 104.940 55.754 1.00 7.81 ? 150 ASP M N 1 ATOM 1164 C CA . ASP A 1 150 ? 66.738 104.491 55.461 1.00 7.11 ? 150 ASP M CA 1 ATOM 1165 C C . ASP A 1 150 ? 66.908 102.981 55.577 1.00 7.95 ? 150 ASP M C 1 ATOM 1166 O O . ASP A 1 150 ? 67.705 102.393 54.852 1.00 8.98 ? 150 ASP M O 1 ATOM 1167 C CB . ASP A 1 150 ? 67.754 105.239 56.325 1.00 8.65 ? 150 ASP M CB 1 ATOM 1168 C CG . ASP A 1 150 ? 67.918 106.686 55.898 1.00 11.52 ? 150 ASP M CG 1 ATOM 1169 O OD1 . ASP A 1 150 ? 67.599 107.004 54.731 1.00 13.48 ? 150 ASP M OD1 1 ATOM 1170 O OD2 . ASP A 1 150 ? 68.370 107.509 56.719 1.00 12.16 ? 150 ASP M OD2 1 ATOM 1171 N N . GLU A 1 151 ? 66.135 102.347 56.454 1.00 8.26 ? 151 GLU M N 1 ATOM 1172 C CA . GLU A 1 151 ? 66.226 100.898 56.615 1.00 8.18 ? 151 GLU M CA 1 ATOM 1173 C C . GLU A 1 151 ? 65.619 100.139 55.445 1.00 8.59 ? 151 GLU M C 1 ATOM 1174 O O . GLU A 1 151 ? 66.239 99.222 54.911 1.00 10.39 ? 151 GLU M O 1 ATOM 1175 C CB . GLU A 1 151 ? 65.506 100.429 57.879 1.00 9.71 ? 151 GLU M CB 1 ATOM 1176 C CG . GLU A 1 151 ? 66.239 100.663 59.177 1.00 12.92 ? 151 GLU M CG 1 ATOM 1177 C CD . GLU A 1 151 ? 65.505 100.022 60.334 1.00 14.80 ? 151 GLU M CD 1 ATOM 1178 O OE1 . GLU A 1 151 ? 65.672 98.808 60.548 1.00 18.84 ? 151 GLU M OE1 1 ATOM 1179 O OE2 . GLU A 1 151 ? 64.719 100.713 61.000 1.00 17.40 ? 151 GLU M OE2 1 ATOM 1180 N N . TYR A 1 152 ? 64.409 100.528 55.044 1.00 7.30 ? 152 TYR M N 1 ATOM 1181 C CA . TYR A 1 152 ? 63.712 99.823 53.974 1.00 6.81 ? 152 TYR M CA 1 ATOM 1182 C C . TYR A 1 152 ? 62.878 100.714 53.059 1.00 7.31 ? 152 TYR M C 1 ATOM 1183 O O . TYR A 1 152 ? 61.971 100.236 52.379 1.00 9.14 ? 152 TYR M O 1 ATOM 1184 C CB . TYR A 1 152 ? 62.824 98.722 54.584 1.00 7.96 ? 152 TYR M CB 1 ATOM 1185 C CG . TYR A 1 152 ? 61.870 99.191 55.672 1.00 7.52 ? 152 TYR M CG 1 ATOM 1186 C CD1 . TYR A 1 152 ? 60.701 99.886 55.353 1.00 7.56 ? 152 TYR M CD1 1 ATOM 1187 C CD2 . TYR A 1 152 ? 62.114 98.901 57.018 1.00 7.47 ? 152 TYR M CD2 1 ATOM 1188 C CE1 . TYR A 1 152 ? 59.800 100.272 56.338 1.00 9.37 ? 152 TYR M CE1 1 ATOM 1189 C CE2 . TYR A 1 152 ? 61.212 99.283 58.014 1.00 9.19 ? 152 TYR M CE2 1 ATOM 1190 C CZ . TYR A 1 152 ? 60.058 99.966 57.662 1.00 8.99 ? 152 TYR M CZ 1 ATOM 1191 O OH . TYR A 1 152 ? 59.140 100.322 58.625 1.00 8.82 ? 152 TYR M OH 1 ATOM 1192 N N . GLU A 1 153 ? 63.214 101.998 53.022 1.00 7.32 ? 153 GLU M N 1 ATOM 1193 C CA . GLU A 1 153 ? 62.505 102.978 52.203 1.00 7.90 ? 153 GLU M CA 1 ATOM 1194 C C . GLU A 1 153 ? 61.028 103.155 52.558 1.00 9.13 ? 153 GLU M C 1 ATOM 1195 O O . GLU A 1 153 ? 60.162 103.295 51.685 1.00 8.13 ? 153 GLU M O 1 ATOM 1196 C CB . GLU A 1 153 ? 62.709 102.718 50.706 1.00 8.64 ? 153 GLU M CB 1 ATOM 1197 C CG . GLU A 1 153 ? 64.157 102.948 50.226 1.00 8.94 ? 153 GLU M CG 1 ATOM 1198 C CD . GLU A 1 153 ? 64.641 104.399 50.367 1.00 10.25 ? 153 GLU M CD 1 ATOM 1199 O OE1 . GLU A 1 153 ? 63.821 105.338 50.330 1.00 9.79 ? 153 GLU M OE1 1 ATOM 1200 O OE2 . GLU A 1 153 ? 65.862 104.610 50.491 1.00 13.80 ? 153 GLU M OE2 1 ATOM 1201 N N . GLY A 1 154 ? 60.760 103.154 53.862 1.00 8.08 ? 154 GLY M N 1 ATOM 1202 C CA . GLY A 1 154 ? 59.419 103.378 54.375 1.00 6.50 ? 154 GLY M CA 1 ATOM 1203 C C . GLY A 1 154 ? 58.263 102.641 53.738 1.00 7.89 ? 154 GLY M C 1 ATOM 1204 O O . GLY A 1 154 ? 58.269 101.417 53.643 1.00 7.53 ? 154 GLY M O 1 ATOM 1205 N N . PHE A 1 155 ? 57.270 103.400 53.283 1.00 6.79 ? 155 PHE M N 1 ATOM 1206 C CA . PHE A 1 155 ? 56.084 102.811 52.675 1.00 6.44 ? 155 PHE M CA 1 ATOM 1207 C C . PHE A 1 155 ? 56.308 102.069 51.368 1.00 8.10 ? 155 PHE M C 1 ATOM 1208 O O . PHE A 1 155 ? 55.383 101.458 50.840 1.00 9.16 ? 155 PHE M O 1 ATOM 1209 C CB . PHE A 1 155 ? 54.965 103.845 52.547 1.00 7.17 ? 155 PHE M CB 1 ATOM 1210 C CG . PHE A 1 155 ? 54.213 104.066 53.833 1.00 6.67 ? 155 PHE M CG 1 ATOM 1211 C CD1 . PHE A 1 155 ? 54.678 104.977 54.781 1.00 7.66 ? 155 PHE M CD1 1 ATOM 1212 C CD2 . PHE A 1 155 ? 53.037 103.365 54.094 1.00 8.56 ? 155 PHE M CD2 1 ATOM 1213 C CE1 . PHE A 1 155 ? 53.993 105.166 55.980 1.00 7.98 ? 155 PHE M CE1 1 ATOM 1214 C CE2 . PHE A 1 155 ? 52.345 103.547 55.291 1.00 8.75 ? 155 PHE M CE2 1 ATOM 1215 C CZ . PHE A 1 155 ? 52.818 104.457 56.231 1.00 8.17 ? 155 PHE M CZ 1 ATOM 1216 N N . LEU A 1 156 ? 57.532 102.111 50.851 1.00 7.76 ? 156 LEU M N 1 ATOM 1217 C CA . LEU A 1 156 ? 57.848 101.390 49.624 1.00 7.50 ? 156 LEU M CA 1 ATOM 1218 C C . LEU A 1 156 ? 57.985 99.894 49.929 1.00 8.13 ? 156 LEU M C 1 ATOM 1219 O O . LEU A 1 156 ? 57.857 99.056 49.037 1.00 9.91 ? 156 LEU M O 1 ATOM 1220 C CB . LEU A 1 156 ? 59.154 101.918 49.021 1.00 8.25 ? 156 LEU M CB 1 ATOM 1221 C CG . LEU A 1 156 ? 59.565 101.330 47.668 1.00 10.42 ? 156 LEU M CG 1 ATOM 1222 C CD1 . LEU A 1 156 ? 58.499 101.634 46.626 1.00 10.31 ? 156 LEU M CD1 1 ATOM 1223 C CD2 . LEU A 1 156 ? 60.899 101.914 47.245 1.00 9.61 ? 156 LEU M CD2 1 ATOM 1224 N N . ASP A 1 157 ? 58.183 99.566 51.204 1.00 7.81 ? 157 ASP M N 1 ATOM 1225 C CA . ASP A 1 157 ? 58.375 98.183 51.641 1.00 8.27 ? 157 ASP M CA 1 ATOM 1226 C C . ASP A 1 157 ? 57.265 97.702 52.575 1.00 10.18 ? 157 ASP M C 1 ATOM 1227 O O . ASP A 1 157 ? 56.761 98.468 53.393 1.00 8.91 ? 157 ASP M O 1 ATOM 1228 C CB . ASP A 1 157 ? 59.724 98.084 52.360 1.00 10.50 ? 157 ASP M CB 1 ATOM 1229 C CG . ASP A 1 157 ? 60.209 96.662 52.509 1.00 12.89 ? 157 ASP M CG 1 ATOM 1230 O OD1 . ASP A 1 157 ? 59.755 95.966 53.440 1.00 11.30 ? 157 ASP M OD1 1 ATOM 1231 O OD2 . ASP A 1 157 ? 61.053 96.240 51.694 1.00 17.93 ? 157 ASP M OD2 1 ATOM 1232 N N . PRO A 1 158 ? 56.864 96.422 52.460 1.00 10.64 ? 158 PRO M N 1 ATOM 1233 C CA . PRO A 1 158 ? 55.807 95.880 53.321 1.00 10.33 ? 158 PRO M CA 1 ATOM 1234 C C . PRO A 1 158 ? 56.138 95.876 54.819 1.00 7.84 ? 158 PRO M C 1 ATOM 1235 O O . PRO A 1 158 ? 55.242 95.742 55.651 1.00 10.03 ? 158 PRO M O 1 ATOM 1236 C CB . PRO A 1 158 ? 55.585 94.471 52.757 1.00 13.03 ? 158 PRO M CB 1 ATOM 1237 C CG . PRO A 1 158 ? 56.878 94.134 52.115 1.00 15.12 ? 158 PRO M CG 1 ATOM 1238 C CD . PRO A 1 158 ? 57.268 95.432 51.448 1.00 12.42 ? 158 PRO M CD 1 ATOM 1239 N N . GLN A 1 159 ? 57.415 96.045 55.165 1.00 8.46 ? 159 GLN M N 1 ATOM 1240 C CA . GLN A 1 159 ? 57.824 96.095 56.570 1.00 8.72 ? 159 GLN M CA 1 ATOM 1241 C C . GLN A 1 159 ? 57.182 97.278 57.294 1.00 10.45 ? 159 GLN M C 1 ATOM 1242 O O . GLN A 1 159 ? 57.084 97.287 58.518 1.00 9.55 ? 159 GLN M O 1 ATOM 1243 C CB . GLN A 1 159 ? 59.345 96.192 56.684 1.00 11.88 ? 159 GLN M CB 1 ATOM 1244 C CG . GLN A 1 159 ? 60.054 94.888 56.381 1.00 18.38 ? 159 GLN M CG 1 ATOM 1245 C CD . GLN A 1 159 ? 61.548 95.060 56.266 1.00 22.03 ? 159 GLN M CD 1 ATOM 1246 O OE1 . GLN A 1 159 ? 62.263 95.063 57.266 1.00 32.06 ? 159 GLN M OE1 1 ATOM 1247 N NE2 . GLN A 1 159 ? 62.030 95.215 55.041 1.00 26.31 ? 159 GLN M NE2 1 ATOM 1248 N N . ILE A 1 160 ? 56.739 98.276 56.533 1.00 8.63 ? 160 ILE M N 1 ATOM 1249 C CA . ILE A 1 160 ? 56.099 99.451 57.124 1.00 7.76 ? 160 ILE M CA 1 ATOM 1250 C C . ILE A 1 160 ? 54.792 99.084 57.838 1.00 10.05 ? 160 ILE M C 1 ATOM 1251 O O . ILE A 1 160 ? 54.393 99.740 58.801 1.00 8.84 ? 160 ILE M O 1 ATOM 1252 C CB . ILE A 1 160 ? 55.794 100.524 56.039 1.00 8.81 ? 160 ILE M CB 1 ATOM 1253 C CG1 . ILE A 1 160 ? 55.378 101.843 56.691 1.00 8.63 ? 160 ILE M CG1 1 ATOM 1254 C CG2 . ILE A 1 160 ? 54.676 100.045 55.111 1.00 8.49 ? 160 ILE M CG2 1 ATOM 1255 C CD1 . ILE A 1 160 ? 56.496 102.528 57.445 1.00 7.05 ? 160 ILE M CD1 1 ATOM 1256 N N . ILE A 1 161 ? 54.130 98.032 57.363 1.00 8.82 ? 161 ILE M N 1 ATOM 1257 C CA . ILE A 1 161 ? 52.861 97.610 57.941 1.00 8.92 ? 161 ILE M CA 1 ATOM 1258 C C . ILE A 1 161 ? 52.970 97.283 59.427 1.00 9.57 ? 161 ILE M C 1 ATOM 1259 O O . ILE A 1 161 ? 52.248 97.856 60.240 1.00 10.25 ? 161 ILE M O 1 ATOM 1260 C CB . ILE A 1 161 ? 52.258 96.430 57.151 1.00 10.32 ? 161 ILE M CB 1 ATOM 1261 C CG1 . ILE A 1 161 ? 52.008 96.863 55.706 1.00 10.81 ? 161 ILE M CG1 1 ATOM 1262 C CG2 . ILE A 1 161 ? 50.943 95.993 57.780 1.00 10.55 ? 161 ILE M CG2 1 ATOM 1263 C CD1 . ILE A 1 161 ? 51.766 95.712 54.743 1.00 12.24 ? 161 ILE M CD1 1 ATOM 1264 N N . ASP A 1 162 ? 53.903 96.410 59.790 1.00 9.77 ? 162 ASP M N 1 ATOM 1265 C CA . ASP A 1 162 ? 54.074 96.046 61.196 1.00 11.35 ? 162 ASP M CA 1 ATOM 1266 C C . ASP A 1 162 ? 54.600 97.191 62.057 1.00 9.42 ? 162 ASP M C 1 ATOM 1267 O O . ASP A 1 162 ? 54.177 97.353 63.202 1.00 9.66 ? 162 ASP M O 1 ATOM 1268 C CB . ASP A 1 162 ? 54.971 94.816 61.337 1.00 15.92 ? 162 ASP M CB 1 ATOM 1269 C CG . ASP A 1 162 ? 54.242 93.516 61.015 1.00 23.12 ? 162 ASP M CG 1 ATOM 1270 O OD1 . ASP A 1 162 ? 52.991 93.517 60.941 1.00 27.37 ? 162 ASP M OD1 1 ATOM 1271 O OD2 . ASP A 1 162 ? 54.925 92.485 60.844 1.00 26.81 ? 162 ASP M OD2 1 ATOM 1272 N N . ASP A 1 163 ? 55.512 97.990 61.512 1.00 7.82 ? 163 ASP M N 1 ATOM 1273 C CA . ASP A 1 163 ? 56.057 99.117 62.269 1.00 8.01 ? 163 ASP M CA 1 ATOM 1274 C C . ASP A 1 163 ? 54.981 100.172 62.513 1.00 8.45 ? 163 ASP M C 1 ATOM 1275 O O . ASP A 1 163 ? 54.901 100.743 63.602 1.00 7.98 ? 163 ASP M O 1 ATOM 1276 C CB . ASP A 1 163 ? 57.276 99.719 61.562 1.00 9.31 ? 163 ASP M CB 1 ATOM 1277 C CG . ASP A 1 163 ? 58.519 98.849 61.697 1.00 12.41 ? 163 ASP M CG 1 ATOM 1278 O OD1 . ASP A 1 163 ? 58.572 97.997 62.612 1.00 13.88 ? 163 ASP M OD1 1 ATOM 1279 O OD2 . ASP A 1 163 ? 59.458 99.020 60.898 1.00 12.58 ? 163 ASP M OD2 1 ATOM 1280 N N . PHE A 1 164 ? 54.135 100.406 61.512 1.00 6.99 ? 164 PHE M N 1 ATOM 1281 C CA . PHE A 1 164 ? 53.053 101.376 61.658 1.00 7.78 ? 164 PHE M CA 1 ATOM 1282 C C . PHE A 1 164 ? 52.028 100.832 62.653 1.00 7.86 ? 164 PHE M C 1 ATOM 1283 O O . PHE A 1 164 ? 51.520 101.569 63.497 1.00 8.21 ? 164 PHE M O 1 ATOM 1284 C CB . PHE A 1 164 ? 52.385 101.666 60.309 1.00 8.62 ? 164 PHE M CB 1 ATOM 1285 C CG . PHE A 1 164 ? 51.323 102.732 60.373 1.00 9.10 ? 164 PHE M CG 1 ATOM 1286 C CD1 . PHE A 1 164 ? 51.592 103.973 60.946 1.00 9.40 ? 164 PHE M CD1 1 ATOM 1287 C CD2 . PHE A 1 164 ? 50.048 102.491 59.868 1.00 9.24 ? 164 PHE M CD2 1 ATOM 1288 C CE1 . PHE A 1 164 ? 50.612 104.954 61.022 1.00 9.53 ? 164 PHE M CE1 1 ATOM 1289 C CE2 . PHE A 1 164 ? 49.056 103.472 59.939 1.00 11.72 ? 164 PHE M CE2 1 ATOM 1290 C CZ . PHE A 1 164 ? 49.340 104.704 60.514 1.00 10.04 ? 164 PHE M CZ 1 ATOM 1291 N N . LYS A 1 165 ? 51.745 99.534 62.564 1.00 8.83 ? 165 LYS M N 1 ATOM 1292 C CA . LYS A 1 165 ? 50.791 98.902 63.472 1.00 8.19 ? 165 LYS M CA 1 ATOM 1293 C C . LYS A 1 165 ? 51.254 99.029 64.923 1.00 8.54 ? 165 LYS M C 1 ATOM 1294 O O . LYS A 1 165 ? 50.460 99.354 65.803 1.00 8.90 ? 165 LYS M O 1 ATOM 1295 C CB . LYS A 1 165 ? 50.608 97.423 63.115 1.00 9.98 ? 165 LYS M CB 1 ATOM 1296 C CG . LYS A 1 165 ? 49.655 96.684 64.045 1.00 13.71 ? 165 LYS M CG 1 ATOM 1297 C CD . LYS A 1 165 ? 49.581 95.206 63.710 1.00 20.29 ? 165 LYS M CD 1 ATOM 1298 C CE . LYS A 1 165 ? 48.606 94.493 64.629 1.00 23.84 ? 165 LYS M CE 1 ATOM 1299 N NZ . LYS A 1 165 ? 48.474 93.052 64.272 1.00 28.19 ? 165 LYS M NZ 1 ATOM 1300 N N . ASP A 1 166 ? 52.541 98.785 65.169 1.00 8.86 ? 166 ASP M N 1 ATOM 1301 C CA . ASP A 1 166 ? 53.085 98.877 66.525 1.00 9.07 ? 166 ASP M CA 1 ATOM 1302 C C . ASP A 1 166 ? 53.031 100.304 67.055 1.00 8.39 ? 166 ASP M C 1 ATOM 1303 O O . ASP A 1 166 ? 52.780 100.525 68.238 1.00 8.71 ? 166 ASP M O 1 ATOM 1304 C CB . ASP A 1 166 ? 54.520 98.344 66.576 1.00 9.99 ? 166 ASP M CB 1 ATOM 1305 C CG . ASP A 1 166 ? 54.597 96.835 66.382 1.00 14.83 ? 166 ASP M CG 1 ATOM 1306 O OD1 . ASP A 1 166 ? 53.593 96.131 66.627 1.00 16.32 ? 166 ASP M OD1 1 ATOM 1307 O OD2 . ASP A 1 166 ? 55.678 96.346 65.998 1.00 16.78 ? 166 ASP M OD2 1 ATOM 1308 N N . TYR A 1 167 ? 53.254 101.270 66.167 1.00 6.55 ? 167 TYR M N 1 ATOM 1309 C CA . TYR A 1 167 ? 53.196 102.682 66.528 1.00 6.63 ? 167 TYR M CA 1 ATOM 1310 C C . TYR A 1 167 ? 51.752 103.068 66.872 1.00 8.24 ? 167 TYR M C 1 ATOM 1311 O O . TYR A 1 167 ? 51.502 103.708 67.892 1.00 6.85 ? 167 TYR M O 1 ATOM 1312 C CB . TYR A 1 167 ? 53.724 103.532 65.367 1.00 6.23 ? 167 TYR M CB 1 ATOM 1313 C CG . TYR A 1 167 ? 53.278 104.971 65.373 1.00 7.00 ? 167 TYR M CG 1 ATOM 1314 C CD1 . TYR A 1 167 ? 53.600 105.823 66.430 1.00 7.76 ? 167 TYR M CD1 1 ATOM 1315 C CD2 . TYR A 1 167 ? 52.545 105.489 64.307 1.00 9.84 ? 167 TYR M CD2 1 ATOM 1316 C CE1 . TYR A 1 167 ? 53.206 107.151 66.421 1.00 9.14 ? 167 TYR M CE1 1 ATOM 1317 C CE2 . TYR A 1 167 ? 52.146 106.816 64.290 1.00 8.22 ? 167 TYR M CE2 1 ATOM 1318 C CZ . TYR A 1 167 ? 52.482 107.642 65.348 1.00 9.15 ? 167 TYR M CZ 1 ATOM 1319 O OH . TYR A 1 167 ? 52.106 108.961 65.315 1.00 9.29 ? 167 TYR M OH 1 ATOM 1320 N N . ALA A 1 168 ? 50.805 102.656 66.030 1.00 7.65 ? 168 ALA M N 1 ATOM 1321 C CA . ALA A 1 168 ? 49.400 102.963 66.268 1.00 7.32 ? 168 ALA M CA 1 ATOM 1322 C C . ALA A 1 168 ? 48.934 102.330 67.573 1.00 7.33 ? 168 ALA M C 1 ATOM 1323 O O . ALA A 1 168 ? 48.183 102.943 68.330 1.00 7.51 ? 168 ALA M O 1 ATOM 1324 C CB . ALA A 1 168 ? 48.538 102.477 65.108 1.00 7.55 ? 168 ALA M CB 1 ATOM 1325 N N . ASP A 1 169 ? 49.408 101.116 67.842 1.00 6.87 ? 169 ASP M N 1 ATOM 1326 C CA . ASP A 1 169 ? 49.044 100.410 69.064 1.00 8.55 ? 169 ASP M CA 1 ATOM 1327 C C . ASP A 1 169 ? 49.466 101.220 70.284 1.00 8.14 ? 169 ASP M C 1 ATOM 1328 O O . ASP A 1 169 ? 48.717 101.329 71.251 1.00 9.12 ? 169 ASP M O 1 ATOM 1329 C CB . ASP A 1 169 ? 49.699 99.031 69.109 1.00 8.02 ? 169 ASP M CB 1 ATOM 1330 C CG . ASP A 1 169 ? 49.286 98.239 70.331 1.00 13.21 ? 169 ASP M CG 1 ATOM 1331 O OD1 . ASP A 1 169 ? 48.103 97.864 70.415 1.00 13.58 ? 169 ASP M OD1 1 ATOM 1332 O OD2 . ASP A 1 169 ? 50.129 98.016 71.222 1.00 18.11 ? 169 ASP M OD2 1 ATOM 1333 N N . LEU A 1 170 ? 50.667 101.792 70.227 1.00 8.83 ? 170 LEU M N 1 ATOM 1334 C CA . LEU A 1 170 ? 51.174 102.612 71.322 1.00 8.27 ? 170 LEU M CA 1 ATOM 1335 C C . LEU A 1 170 ? 50.267 103.824 71.521 1.00 8.69 ? 170 LEU M C 1 ATOM 1336 O O . LEU A 1 170 ? 49.944 104.183 72.648 1.00 8.96 ? 170 LEU M O 1 ATOM 1337 C CB . LEU A 1 170 ? 52.599 103.084 71.019 1.00 8.06 ? 170 LEU M CB 1 ATOM 1338 C CG . LEU A 1 170 ? 53.210 104.034 72.052 1.00 10.50 ? 170 LEU M CG 1 ATOM 1339 C CD1 . LEU A 1 170 ? 53.348 103.330 73.390 1.00 12.39 ? 170 LEU M CD1 1 ATOM 1340 C CD2 . LEU A 1 170 ? 54.564 104.525 71.568 1.00 10.88 ? 170 LEU M CD2 1 ATOM 1341 N N . CYS A 1 171 ? 49.857 104.447 70.418 1.00 7.47 ? 171 CYS M N 1 ATOM 1342 C CA . CYS A 1 171 ? 48.979 105.614 70.477 1.00 7.58 ? 171 CYS M CA 1 ATOM 1343 C C . CYS A 1 171 ? 47.616 105.287 71.084 1.00 6.81 ? 171 CYS M C 1 ATOM 1344 O O . CYS A 1 171 ? 47.103 106.043 71.904 1.00 7.93 ? 171 CYS M O 1 ATOM 1345 C CB . CYS A 1 171 ? 48.798 106.215 69.088 1.00 7.46 ? 171 CYS M CB 1 ATOM 1346 S SG . CYS A 1 171 ? 50.305 106.969 68.429 1.00 8.91 ? 171 CYS M SG 1 ATOM 1347 N N . PHE A 1 172 ? 47.016 104.177 70.662 1.00 8.81 ? 172 PHE M N 1 ATOM 1348 C CA . PHE A 1 172 ? 45.715 103.781 71.202 1.00 7.20 ? 172 PHE M CA 1 ATOM 1349 C C . PHE A 1 172 ? 45.849 103.484 72.695 1.00 8.17 ? 172 PHE M C 1 ATOM 1350 O O . PHE A 1 172 ? 45.022 103.904 73.499 1.00 9.28 ? 172 PHE M O 1 ATOM 1351 C CB . PHE A 1 172 ? 45.182 102.536 70.489 1.00 9.31 ? 172 PHE M CB 1 ATOM 1352 C CG . PHE A 1 172 ? 44.994 102.710 69.005 1.00 7.84 ? 172 PHE M CG 1 ATOM 1353 C CD1 . PHE A 1 172 ? 44.648 103.948 68.467 1.00 7.23 ? 172 PHE M CD1 1 ATOM 1354 C CD2 . PHE A 1 172 ? 45.163 101.630 68.145 1.00 8.05 ? 172 PHE M CD2 1 ATOM 1355 C CE1 . PHE A 1 172 ? 44.462 104.100 67.094 1.00 7.88 ? 172 PHE M CE1 1 ATOM 1356 C CE2 . PHE A 1 172 ? 44.981 101.769 66.772 1.00 8.62 ? 172 PHE M CE2 1 ATOM 1357 C CZ . PHE A 1 172 ? 44.633 103.005 66.242 1.00 8.37 ? 172 PHE M CZ 1 ATOM 1358 N N . GLU A 1 173 ? 46.909 102.767 73.049 1.00 9.54 ? 173 GLU M N 1 ATOM 1359 C CA . GLU A 1 173 ? 47.178 102.399 74.435 1.00 11.36 ? 173 GLU M CA 1 ATOM 1360 C C . GLU A 1 173 ? 47.355 103.625 75.326 1.00 11.95 ? 173 GLU M C 1 ATOM 1361 O O . GLU A 1 173 ? 46.748 103.722 76.393 1.00 13.88 ? 173 GLU M O 1 ATOM 1362 C CB . GLU A 1 173 ? 48.442 101.535 74.489 1.00 13.94 ? 173 GLU M CB 1 ATOM 1363 C CG . GLU A 1 173 ? 48.949 101.203 75.882 1.00 21.15 ? 173 GLU M CG 1 ATOM 1364 C CD . GLU A 1 173 ? 50.303 100.521 75.844 1.00 25.08 ? 173 GLU M CD 1 ATOM 1365 O OE1 . GLU A 1 173 ? 50.366 99.350 75.412 1.00 28.30 ? 173 GLU M OE1 1 ATOM 1366 O OE2 . GLU A 1 173 ? 51.307 101.162 76.229 1.00 28.20 ? 173 GLU M OE2 1 ATOM 1367 N N . GLU A 1 174 ? 48.157 104.578 74.864 1.00 10.36 ? 174 GLU M N 1 ATOM 1368 C CA . GLU A 1 174 ? 48.440 105.778 75.642 1.00 10.55 ? 174 GLU M CA 1 ATOM 1369 C C . GLU A 1 174 ? 47.391 106.877 75.640 1.00 11.73 ? 174 GLU M C 1 ATOM 1370 O O . GLU A 1 174 ? 47.104 107.466 76.684 1.00 11.90 ? 174 GLU M O 1 ATOM 1371 C CB . GLU A 1 174 ? 49.776 106.388 75.195 1.00 11.28 ? 174 GLU M CB 1 ATOM 1372 C CG . GLU A 1 174 ? 50.984 105.509 75.467 1.00 16.30 ? 174 GLU M CG 1 ATOM 1373 C CD . GLU A 1 174 ? 51.203 105.267 76.948 1.00 22.81 ? 174 GLU M CD 1 ATOM 1374 O OE1 . GLU A 1 174 ? 51.061 106.228 77.735 1.00 23.14 ? 174 GLU M OE1 1 ATOM 1375 O OE2 . GLU A 1 174 ? 51.502 104.112 77.323 1.00 27.85 ? 174 GLU M OE2 1 ATOM 1376 N N . PHE A 1 175 ? 46.784 107.122 74.485 1.00 9.59 ? 175 PHE M N 1 ATOM 1377 C CA . PHE A 1 175 ? 45.835 108.223 74.354 1.00 8.65 ? 175 PHE M CA 1 ATOM 1378 C C . PHE A 1 175 ? 44.380 107.867 74.092 1.00 9.27 ? 175 PHE M C 1 ATOM 1379 O O . PHE A 1 175 ? 43.512 108.735 74.186 1.00 9.75 ? 175 PHE M O 1 ATOM 1380 C CB . PHE A 1 175 ? 46.323 109.144 73.230 1.00 8.77 ? 175 PHE M CB 1 ATOM 1381 C CG . PHE A 1 175 ? 47.804 109.425 73.271 1.00 8.67 ? 175 PHE M CG 1 ATOM 1382 C CD1 . PHE A 1 175 ? 48.369 110.082 74.357 1.00 8.27 ? 175 PHE M CD1 1 ATOM 1383 C CD2 . PHE A 1 175 ? 48.632 109.007 72.234 1.00 10.05 ? 175 PHE M CD2 1 ATOM 1384 C CE1 . PHE A 1 175 ? 49.738 110.338 74.403 1.00 10.16 ? 175 PHE M CE1 1 ATOM 1385 C CE2 . PHE A 1 175 ? 50.004 109.256 72.266 1.00 10.10 ? 175 PHE M CE2 1 ATOM 1386 C CZ . PHE A 1 175 ? 50.560 109.917 73.361 1.00 10.36 ? 175 PHE M CZ 1 ATOM 1387 N N . GLY A 1 176 ? 44.127 106.604 73.754 1.00 9.28 ? 176 GLY M N 1 ATOM 1388 C CA . GLY A 1 176 ? 42.786 106.146 73.429 1.00 10.06 ? 176 GLY M CA 1 ATOM 1389 C C . GLY A 1 176 ? 41.685 106.318 74.454 1.00 10.33 ? 176 GLY M C 1 ATOM 1390 O O . GLY A 1 176 ? 40.508 106.282 74.098 1.00 9.64 ? 176 GLY M O 1 ATOM 1391 N N . ASP A 1 177 ? 42.044 106.453 75.727 1.00 14.27 ? 177 ASP M N 1 ATOM 1392 C CA . ASP A 1 177 ? 41.030 106.645 76.756 1.00 15.66 ? 177 ASP M CA 1 ATOM 1393 C C . ASP A 1 177 ? 40.422 108.038 76.668 1.00 15.50 ? 177 ASP M C 1 ATOM 1394 O O . ASP A 1 177 ? 39.303 108.263 77.127 1.00 14.21 ? 177 ASP M O 1 ATOM 1395 C CB . ASP A 1 177 ? 41.612 106.405 78.150 1.00 20.10 ? 177 ASP M CB 1 ATOM 1396 C CG . ASP A 1 177 ? 41.831 104.932 78.444 1.00 28.57 ? 177 ASP M CG 1 ATOM 1397 O OD1 . ASP A 1 177 ? 41.010 104.100 77.998 1.00 30.59 ? 177 ASP M OD1 1 ATOM 1398 O OD2 . ASP A 1 177 ? 42.824 104.603 79.127 1.00 34.24 ? 177 ASP M OD2 1 ATOM 1399 N N . SER A 1 178 ? 41.148 108.960 76.040 1.00 12.46 ? 178 SER M N 1 ATOM 1400 C CA . SER A 1 178 ? 40.683 110.335 75.891 1.00 13.38 ? 178 SER M CA 1 ATOM 1401 C C . SER A 1 178 ? 40.364 110.700 74.442 1.00 12.93 ? 178 SER M C 1 ATOM 1402 O O . SER A 1 178 ? 39.455 111.490 74.180 1.00 14.03 ? 178 SER M O 1 ATOM 1403 C CB . SER A 1 178 ? 41.725 111.304 76.458 1.00 15.69 ? 178 SER M CB 1 ATOM 1404 O OG . SER A 1 178 ? 41.871 111.134 77.860 1.00 24.36 ? 178 SER M OG 1 ATOM 1405 N N . VAL A 1 179 ? 41.110 110.123 73.506 1.00 9.27 ? 179 VAL M N 1 ATOM 1406 C CA . VAL A 1 179 ? 40.909 110.389 72.081 1.00 7.35 ? 179 VAL M CA 1 ATOM 1407 C C . VAL A 1 179 ? 39.913 109.387 71.510 1.00 9.12 ? 179 VAL M C 1 ATOM 1408 O O . VAL A 1 179 ? 40.142 108.182 71.578 1.00 11.55 ? 179 VAL M O 1 ATOM 1409 C CB . VAL A 1 179 ? 42.234 110.279 71.303 1.00 8.30 ? 179 VAL M CB 1 ATOM 1410 C CG1 . VAL A 1 179 ? 41.982 110.437 69.807 1.00 9.06 ? 179 VAL M CG1 1 ATOM 1411 C CG2 . VAL A 1 179 ? 43.215 111.334 71.798 1.00 10.30 ? 179 VAL M CG2 1 ATOM 1412 N N . LYS A 1 180 ? 38.818 109.894 70.947 1.00 9.11 ? 180 LYS M N 1 ATOM 1413 C CA . LYS A 1 180 ? 37.767 109.042 70.393 1.00 9.45 ? 180 LYS M CA 1 ATOM 1414 C C . LYS A 1 180 ? 37.609 109.145 68.880 1.00 9.07 ? 180 LYS M C 1 ATOM 1415 O O . LYS A 1 180 ? 36.725 108.515 68.301 1.00 11.04 ? 180 LYS M O 1 ATOM 1416 C CB . LYS A 1 180 ? 36.426 109.344 71.077 1.00 10.07 ? 180 LYS M CB 1 ATOM 1417 C CG . LYS A 1 180 ? 36.487 109.297 72.601 1.00 10.21 ? 180 LYS M CG 1 ATOM 1418 C CD . LYS A 1 180 ? 36.962 107.946 73.107 1.00 12.23 ? 180 LYS M CD 1 ATOM 1419 C CE . LYS A 1 180 ? 37.176 107.969 74.619 1.00 13.68 ? 180 LYS M CE 1 ATOM 1420 N NZ . LYS A 1 180 ? 37.706 106.672 75.131 1.00 11.46 ? 180 LYS M NZ 1 ATOM 1421 N N . TYR A 1 181 ? 38.439 109.967 68.244 1.00 8.27 ? 181 TYR M N 1 ATOM 1422 C CA . TYR A 1 181 ? 38.394 110.129 66.795 1.00 7.37 ? 181 TYR M CA 1 ATOM 1423 C C . TYR A 1 181 ? 39.815 110.056 66.280 1.00 7.82 ? 181 TYR M C 1 ATOM 1424 O O . TYR A 1 181 ? 40.625 110.939 66.547 1.00 8.79 ? 181 TYR M O 1 ATOM 1425 C CB . TYR A 1 181 ? 37.773 111.469 66.405 1.00 8.39 ? 181 TYR M CB 1 ATOM 1426 C CG . TYR A 1 181 ? 36.296 111.544 66.679 1.00 10.87 ? 181 TYR M CG 1 ATOM 1427 C CD1 . TYR A 1 181 ? 35.819 112.098 67.864 1.00 12.21 ? 181 TYR M CD1 1 ATOM 1428 C CD2 . TYR A 1 181 ? 35.373 111.051 65.757 1.00 11.76 ? 181 TYR M CD2 1 ATOM 1429 C CE1 . TYR A 1 181 ? 34.456 112.164 68.125 1.00 15.51 ? 181 TYR M CE1 1 ATOM 1430 C CE2 . TYR A 1 181 ? 34.007 111.112 66.009 1.00 15.29 ? 181 TYR M CE2 1 ATOM 1431 C CZ . TYR A 1 181 ? 33.559 111.669 67.195 1.00 16.28 ? 181 TYR M CZ 1 ATOM 1432 O OH . TYR A 1 181 ? 32.208 111.729 67.453 1.00 20.58 ? 181 TYR M OH 1 ATOM 1433 N N . TRP A 1 182 ? 40.112 108.974 65.572 1.00 7.65 ? 182 TRP M N 1 ATOM 1434 C CA . TRP A 1 182 ? 41.436 108.739 65.021 1.00 7.24 ? 182 TRP M CA 1 ATOM 1435 C C . TRP A 1 182 ? 41.455 108.761 63.505 1.00 7.82 ? 182 TRP M C 1 ATOM 1436 O O . TRP A 1 182 ? 40.542 108.248 62.854 1.00 8.62 ? 182 TRP M O 1 ATOM 1437 C CB . TRP A 1 182 ? 41.947 107.368 65.463 1.00 7.33 ? 182 TRP M CB 1 ATOM 1438 C CG . TRP A 1 182 ? 42.203 107.234 66.921 1.00 7.39 ? 182 TRP M CG 1 ATOM 1439 C CD1 . TRP A 1 182 ? 41.385 106.657 67.852 1.00 10.31 ? 182 TRP M CD1 1 ATOM 1440 C CD2 . TRP A 1 182 ? 43.376 107.638 67.614 1.00 7.40 ? 182 TRP M CD2 1 ATOM 1441 N NE1 . TRP A 1 182 ? 41.985 106.670 69.086 1.00 7.55 ? 182 TRP M NE1 1 ATOM 1442 C CE2 . TRP A 1 182 ? 43.222 107.276 68.969 1.00 7.00 ? 182 TRP M CE2 1 ATOM 1443 C CE3 . TRP A 1 182 ? 44.567 108.280 67.225 1.00 7.20 ? 182 TRP M CE3 1 ATOM 1444 C CZ2 . TRP A 1 182 ? 44.192 107.520 69.936 1.00 9.07 ? 182 TRP M CZ2 1 ATOM 1445 C CZ3 . TRP A 1 182 ? 45.539 108.526 68.185 1.00 7.87 ? 182 TRP M CZ3 1 ATOM 1446 C CH2 . TRP A 1 182 ? 45.345 108.148 69.527 1.00 7.97 ? 182 TRP M CH2 1 ATOM 1447 N N . LEU A 1 183 ? 42.500 109.370 62.953 1.00 6.64 ? 183 LEU M N 1 ATOM 1448 C CA . LEU A 1 183 ? 42.712 109.414 61.512 1.00 7.35 ? 183 LEU M CA 1 ATOM 1449 C C . LEU A 1 183 ? 44.008 108.634 61.328 1.00 7.36 ? 183 LEU M C 1 ATOM 1450 O O . LEU A 1 183 ? 44.973 108.846 62.060 1.00 10.28 ? 183 LEU M O 1 ATOM 1451 C CB . LEU A 1 183 ? 42.882 110.852 60.999 1.00 7.30 ? 183 LEU M CB 1 ATOM 1452 C CG . LEU A 1 183 ? 41.681 111.808 60.983 1.00 11.42 ? 183 LEU M CG 1 ATOM 1453 C CD1 . LEU A 1 183 ? 40.486 111.141 60.319 1.00 10.51 ? 183 LEU M CD1 1 ATOM 1454 C CD2 . LEU A 1 183 ? 41.340 112.259 62.389 1.00 20.22 ? 183 LEU M CD2 1 ATOM 1455 N N . THR A 1 184 ? 44.025 107.704 60.382 1.00 6.17 ? 184 THR M N 1 ATOM 1456 C CA . THR A 1 184 ? 45.218 106.892 60.172 1.00 6.45 ? 184 THR M CA 1 ATOM 1457 C C . THR A 1 184 ? 46.311 107.600 59.382 1.00 8.79 ? 184 THR M C 1 ATOM 1458 O O . THR A 1 184 ? 47.310 108.050 59.948 1.00 11.18 ? 184 THR M O 1 ATOM 1459 C CB . THR A 1 184 ? 44.867 105.562 59.493 1.00 7.43 ? 184 THR M CB 1 ATOM 1460 O OG1 . THR A 1 184 ? 44.136 105.821 58.289 1.00 8.52 ? 184 THR M OG1 1 ATOM 1461 C CG2 . THR A 1 184 ? 44.008 104.713 60.418 1.00 8.67 ? 184 THR M CG2 1 ATOM 1462 N N . ILE A 1 185 ? 46.094 107.723 58.079 1.00 8.03 ? 185 ILE M N 1 ATOM 1463 C CA . ILE A 1 185 ? 47.055 108.353 57.186 1.00 7.42 ? 185 ILE M CA 1 ATOM 1464 C C . ILE A 1 185 ? 46.449 109.580 56.525 1.00 8.81 ? 185 ILE M C 1 ATOM 1465 O O . ILE A 1 185 ? 45.335 109.533 55.995 1.00 9.17 ? 185 ILE M O 1 ATOM 1466 C CB . ILE A 1 185 ? 47.527 107.350 56.097 1.00 7.36 ? 185 ILE M CB 1 ATOM 1467 C CG1 . ILE A 1 185 ? 48.247 106.172 56.760 1.00 8.93 ? 185 ILE M CG1 1 ATOM 1468 C CG2 . ILE A 1 185 ? 48.457 108.043 55.089 1.00 9.20 ? 185 ILE M CG2 1 ATOM 1469 C CD1 . ILE A 1 185 ? 48.602 105.041 55.804 1.00 12.84 ? 185 ILE M CD1 1 ATOM 1470 N N . ASN A 1 186 ? 47.175 110.691 56.581 1.00 8.37 ? 186 ASN M N 1 ATOM 1471 C CA . ASN A 1 186 ? 46.698 111.924 55.973 1.00 8.50 ? 186 ASN M CA 1 ATOM 1472 C C . ASN A 1 186 ? 46.794 111.883 54.453 1.00 10.92 ? 186 ASN M C 1 ATOM 1473 O O . ASN A 1 186 ? 47.841 111.530 53.905 1.00 12.18 ? 186 ASN M O 1 ATOM 1474 C CB . ASN A 1 186 ? 47.498 113.119 56.476 1.00 9.54 ? 186 ASN M CB 1 ATOM 1475 C CG . ASN A 1 186 ? 47.017 114.410 55.875 1.00 10.17 ? 186 ASN M CG 1 ATOM 1476 O OD1 . ASN A 1 186 ? 45.864 114.791 56.064 1.00 9.39 ? 186 ASN M OD1 1 ATOM 1477 N ND2 . ASN A 1 186 ? 47.879 115.071 55.106 1.00 10.34 ? 186 ASN M ND2 1 ATOM 1478 N N . GLN A 1 187 ? 45.700 112.271 53.794 1.00 9.32 ? 187 GLN M N 1 ATOM 1479 C CA . GLN A 1 187 ? 45.595 112.323 52.330 1.00 7.77 ? 187 GLN M CA 1 ATOM 1480 C C . GLN A 1 187 ? 46.315 111.188 51.619 1.00 8.60 ? 187 GLN M C 1 ATOM 1481 O O . GLN A 1 187 ? 47.429 111.354 51.121 1.00 7.82 ? 187 GLN M O 1 ATOM 1482 C CB . GLN A 1 187 ? 46.084 113.681 51.814 1.00 7.20 ? 187 GLN M CB 1 ATOM 1483 C CG . GLN A 1 187 ? 45.338 114.856 52.438 1.00 7.79 ? 187 GLN M CG 1 ATOM 1484 C CD . GLN A 1 187 ? 45.693 116.202 51.824 1.00 8.66 ? 187 GLN M CD 1 ATOM 1485 O OE1 . GLN A 1 187 ? 45.092 117.218 52.163 1.00 8.90 ? 187 GLN M OE1 1 ATOM 1486 N NE2 . GLN A 1 187 ? 46.665 116.216 50.916 1.00 9.52 ? 187 GLN M NE2 1 ATOM 1487 N N . LEU A 1 188 ? 45.648 110.042 51.554 1.00 7.10 ? 188 LEU M N 1 ATOM 1488 C CA . LEU A 1 188 ? 46.202 108.843 50.942 1.00 6.89 ? 188 LEU M CA 1 ATOM 1489 C C . LEU A 1 188 ? 46.864 109.042 49.584 1.00 6.57 ? 188 LEU M C 1 ATOM 1490 O O . LEU A 1 188 ? 47.909 108.463 49.311 1.00 7.36 ? 188 LEU M O 1 ATOM 1491 C CB . LEU A 1 188 ? 45.112 107.780 50.838 1.00 6.67 ? 188 LEU M CB 1 ATOM 1492 C CG . LEU A 1 188 ? 44.677 107.185 52.176 1.00 8.43 ? 188 LEU M CG 1 ATOM 1493 C CD1 . LEU A 1 188 ? 43.421 106.336 51.988 1.00 10.56 ? 188 LEU M CD1 1 ATOM 1494 C CD2 . LEU A 1 188 ? 45.818 106.337 52.718 1.00 11.84 ? 188 LEU M CD2 1 ATOM 1495 N N . TYR A 1 189 ? 46.270 109.891 48.756 1.00 6.72 ? 189 TYR M N 1 ATOM 1496 C CA . TYR A 1 189 ? 46.777 110.153 47.412 1.00 6.80 ? 189 TYR M CA 1 ATOM 1497 C C . TYR A 1 189 ? 48.114 110.890 47.344 1.00 7.27 ? 189 TYR M C 1 ATOM 1498 O O . TYR A 1 189 ? 48.906 110.665 46.429 1.00 7.02 ? 189 TYR M O 1 ATOM 1499 C CB . TYR A 1 189 ? 45.715 110.951 46.643 1.00 8.41 ? 189 TYR M CB 1 ATOM 1500 C CG . TYR A 1 189 ? 46.081 111.329 45.224 1.00 6.59 ? 189 TYR M CG 1 ATOM 1501 C CD1 . TYR A 1 189 ? 45.696 110.525 44.153 1.00 8.23 ? 189 TYR M CD1 1 ATOM 1502 C CD2 . TYR A 1 189 ? 46.784 112.507 44.952 1.00 9.98 ? 189 TYR M CD2 1 ATOM 1503 C CE1 . TYR A 1 189 ? 45.999 110.886 42.843 1.00 9.69 ? 189 TYR M CE1 1 ATOM 1504 C CE2 . TYR A 1 189 ? 47.094 112.873 43.652 1.00 11.29 ? 189 TYR M CE2 1 ATOM 1505 C CZ . TYR A 1 189 ? 46.695 112.058 42.603 1.00 11.21 ? 189 TYR M CZ 1 ATOM 1506 O OH . TYR A 1 189 ? 46.983 112.433 41.312 1.00 13.60 ? 189 TYR M OH 1 ATOM 1507 N N . SER A 1 190 ? 48.380 111.722 48.345 1.00 6.12 ? 190 SER M N 1 ATOM 1508 C CA . SER A 1 190 ? 49.568 112.568 48.374 1.00 6.41 ? 190 SER M CA 1 ATOM 1509 C C . SER A 1 190 ? 50.965 111.972 48.381 1.00 6.80 ? 190 SER M C 1 ATOM 1510 O O . SER A 1 190 ? 51.769 112.292 47.503 1.00 8.45 ? 190 SER M O 1 ATOM 1511 C CB . SER A 1 190 ? 49.432 113.594 49.493 1.00 6.92 ? 190 SER M CB 1 ATOM 1512 O OG . SER A 1 190 ? 48.236 114.338 49.329 1.00 7.74 ? 190 SER M OG 1 ATOM 1513 N N . VAL A 1 191 ? 51.282 111.144 49.370 1.00 6.20 ? 191 VAL M N 1 ATOM 1514 C CA . VAL A 1 191 ? 52.623 110.566 49.426 1.00 7.43 ? 191 VAL M CA 1 ATOM 1515 C C . VAL A 1 191 ? 52.972 109.727 48.197 1.00 6.72 ? 191 VAL M C 1 ATOM 1516 O O . VAL A 1 191 ? 54.049 109.888 47.630 1.00 7.81 ? 191 VAL M O 1 ATOM 1517 C CB . VAL A 1 191 ? 52.870 109.770 50.724 1.00 6.75 ? 191 VAL M CB 1 ATOM 1518 C CG1 . VAL A 1 191 ? 54.256 109.120 50.695 1.00 8.89 ? 191 VAL M CG1 1 ATOM 1519 C CG2 . VAL A 1 191 ? 52.772 110.704 51.918 1.00 8.53 ? 191 VAL M CG2 1 ATOM 1520 N N . PRO A 1 192 ? 52.058 108.848 47.744 1.00 5.91 ? 192 PRO M N 1 ATOM 1521 C CA . PRO A 1 192 ? 52.406 108.051 46.563 1.00 6.45 ? 192 PRO M CA 1 ATOM 1522 C C . PRO A 1 192 ? 52.750 108.911 45.348 1.00 7.18 ? 192 PRO M C 1 ATOM 1523 O O . PRO A 1 192 ? 53.743 108.670 44.666 1.00 7.92 ? 192 PRO M O 1 ATOM 1524 C CB . PRO A 1 192 ? 51.131 107.242 46.308 1.00 7.31 ? 192 PRO M CB 1 ATOM 1525 C CG . PRO A 1 192 ? 50.555 107.070 47.679 1.00 9.13 ? 192 PRO M CG 1 ATOM 1526 C CD . PRO A 1 192 ? 50.757 108.430 48.297 1.00 6.36 ? 192 PRO M CD 1 ATOM 1527 N N . THR A 1 193 ? 51.947 109.939 45.104 1.00 4.95 ? 193 THR M N 1 ATOM 1528 C CA . THR A 1 193 ? 52.170 110.789 43.941 1.00 5.72 ? 193 THR M CA 1 ATOM 1529 C C . THR A 1 193 ? 53.255 111.852 44.091 1.00 7.30 ? 193 THR M C 1 ATOM 1530 O O . THR A 1 193 ? 54.157 111.950 43.259 1.00 8.99 ? 193 THR M O 1 ATOM 1531 C CB . THR A 1 193 ? 50.855 111.443 43.470 1.00 6.24 ? 193 THR M CB 1 ATOM 1532 O OG1 . THR A 1 193 ? 50.312 112.254 44.515 1.00 6.72 ? 193 THR M OG1 1 ATOM 1533 C CG2 . THR A 1 193 ? 49.835 110.363 43.101 1.00 7.93 ? 193 THR M CG2 1 ATOM 1534 N N . ARG A 1 194 ? 53.183 112.635 45.159 1.00 6.33 ? 194 ARG M N 1 ATOM 1535 C CA . ARG A 1 194 ? 54.153 113.702 45.380 1.00 8.02 ? 194 ARG M CA 1 ATOM 1536 C C . ARG A 1 194 ? 55.476 113.224 45.960 1.00 7.37 ? 194 ARG M C 1 ATOM 1537 O O . ARG A 1 194 ? 56.529 113.778 45.644 1.00 8.42 ? 194 ARG M O 1 ATOM 1538 C CB . ARG A 1 194 ? 53.553 114.771 46.292 1.00 8.94 ? 194 ARG M CB 1 ATOM 1539 C CG . ARG A 1 194 ? 52.229 115.330 45.799 1.00 11.99 ? 194 ARG M CG 1 ATOM 1540 C CD . ARG A 1 194 ? 51.634 116.305 46.803 1.00 17.01 ? 194 ARG M CD 1 ATOM 1541 N NE . ARG A 1 194 ? 52.475 117.488 46.967 1.00 18.54 ? 194 ARG M NE 1 ATOM 1542 C CZ . ARG A 1 194 ? 52.514 118.511 46.116 1.00 23.96 ? 194 ARG M CZ 1 ATOM 1543 N NH1 . ARG A 1 194 ? 51.754 118.510 45.026 1.00 25.37 ? 194 ARG M NH1 1 ATOM 1544 N NH2 . ARG A 1 194 ? 53.320 119.536 46.349 1.00 24.87 ? 194 ARG M NH2 1 ATOM 1545 N N . GLY A 1 195 ? 55.424 112.184 46.786 1.00 6.83 ? 195 GLY M N 1 ATOM 1546 C CA . GLY A 1 195 ? 56.635 111.678 47.407 1.00 7.98 ? 195 GLY M CA 1 ATOM 1547 C C . GLY A 1 195 ? 57.398 110.652 46.601 1.00 7.98 ? 195 GLY M C 1 ATOM 1548 O O . GLY A 1 195 ? 58.618 110.556 46.725 1.00 8.32 ? 195 GLY M O 1 ATOM 1549 N N . TYR A 1 196 ? 56.683 109.903 45.764 1.00 7.75 ? 196 TYR M N 1 ATOM 1550 C CA . TYR A 1 196 ? 57.284 108.851 44.950 1.00 6.14 ? 196 TYR M CA 1 ATOM 1551 C C . TYR A 1 196 ? 57.038 108.983 43.452 1.00 7.54 ? 196 TYR M C 1 ATOM 1552 O O . TYR A 1 196 ? 57.496 108.142 42.677 1.00 9.32 ? 196 TYR M O 1 ATOM 1553 C CB . TYR A 1 196 ? 56.778 107.482 45.410 1.00 5.78 ? 196 TYR M CB 1 ATOM 1554 C CG . TYR A 1 196 ? 57.261 107.063 46.778 1.00 7.48 ? 196 TYR M CG 1 ATOM 1555 C CD1 . TYR A 1 196 ? 56.652 107.548 47.939 1.00 7.80 ? 196 TYR M CD1 1 ATOM 1556 C CD2 . TYR A 1 196 ? 58.311 106.156 46.911 1.00 7.62 ? 196 TYR M CD2 1 ATOM 1557 C CE1 . TYR A 1 196 ? 57.076 107.127 49.199 1.00 6.09 ? 196 TYR M CE1 1 ATOM 1558 C CE2 . TYR A 1 196 ? 58.739 105.727 48.164 1.00 6.22 ? 196 TYR M CE2 1 ATOM 1559 C CZ . TYR A 1 196 ? 58.121 106.217 49.300 1.00 7.46 ? 196 TYR M CZ 1 ATOM 1560 O OH . TYR A 1 196 ? 58.543 105.787 50.530 1.00 7.39 ? 196 TYR M OH 1 ATOM 1561 N N . GLY A 1 197 ? 56.298 110.014 43.051 1.00 7.60 ? 197 GLY M N 1 ATOM 1562 C CA . GLY A 1 197 ? 56.012 110.218 41.640 1.00 9.00 ? 197 GLY M CA 1 ATOM 1563 C C . GLY A 1 197 ? 56.713 111.446 41.099 1.00 10.25 ? 197 GLY M C 1 ATOM 1564 O O . GLY A 1 197 ? 57.644 111.346 40.296 1.00 10.88 ? 197 GLY M O 1 ATOM 1565 N N . SER A 1 198 ? 56.286 112.614 41.568 1.00 8.96 ? 198 SER M N 1 ATOM 1566 C CA . SER A 1 198 ? 56.866 113.883 41.138 1.00 9.27 ? 198 SER M CA 1 ATOM 1567 C C . SER A 1 198 ? 58.043 114.322 42.008 1.00 9.19 ? 198 SER M C 1 ATOM 1568 O O . SER A 1 198 ? 58.778 115.239 41.642 1.00 10.03 ? 198 SER M O 1 ATOM 1569 C CB . SER A 1 198 ? 55.797 114.969 41.170 1.00 11.33 ? 198 SER M CB 1 ATOM 1570 O OG . SER A 1 198 ? 55.268 115.095 42.475 1.00 11.42 ? 198 SER M OG 1 ATOM 1571 N N . ALA A 1 199 ? 58.182 113.689 43.172 1.00 8.82 ? 199 ALA M N 1 ATOM 1572 C CA . ALA A 1 199 ? 59.244 113.997 44.131 1.00 11.12 ? 199 ALA M CA 1 ATOM 1573 C C . ALA A 1 199 ? 59.171 115.432 44.653 1.00 8.92 ? 199 ALA M C 1 ATOM 1574 O O . ALA A 1 199 ? 60.184 116.036 45.001 1.00 11.11 ? 199 ALA M O 1 ATOM 1575 C CB . ALA A 1 199 ? 60.618 113.704 43.543 1.00 12.14 ? 199 ALA M CB 1 ATOM 1576 N N . LEU A 1 200 ? 57.968 115.993 44.666 1.00 8.28 ? 200 LEU M N 1 ATOM 1577 C CA . LEU A 1 200 ? 57.772 117.339 45.184 1.00 8.25 ? 200 LEU M CA 1 ATOM 1578 C C . LEU A 1 200 ? 57.780 117.282 46.706 1.00 9.53 ? 200 LEU M C 1 ATOM 1579 O O . LEU A 1 200 ? 58.094 118.272 47.372 1.00 9.06 ? 200 LEU M O 1 ATOM 1580 C CB . LEU A 1 200 ? 56.435 117.909 44.714 1.00 10.20 ? 200 LEU M CB 1 ATOM 1581 C CG . LEU A 1 200 ? 56.325 118.225 43.225 1.00 13.64 ? 200 LEU M CG 1 ATOM 1582 C CD1 . LEU A 1 200 ? 54.931 118.754 42.930 1.00 18.25 ? 200 LEU M CD1 1 ATOM 1583 C CD2 . LEU A 1 200 ? 57.386 119.243 42.833 1.00 18.33 ? 200 LEU M CD2 1 ATOM 1584 N N . ASP A 1 201 ? 57.431 116.114 47.242 1.00 9.30 ? 201 ASP M N 1 ATOM 1585 C CA . ASP A 1 201 ? 57.365 115.888 48.686 1.00 6.61 ? 201 ASP M CA 1 ATOM 1586 C C . ASP A 1 201 ? 58.330 114.794 49.128 1.00 7.30 ? 201 ASP M C 1 ATOM 1587 O O . ASP A 1 201 ? 58.829 114.018 48.312 1.00 6.97 ? 201 ASP M O 1 ATOM 1588 C CB . ASP A 1 201 ? 55.956 115.418 49.091 1.00 7.29 ? 201 ASP M CB 1 ATOM 1589 C CG . ASP A 1 201 ? 54.894 116.502 48.969 1.00 10.82 ? 201 ASP M CG 1 ATOM 1590 O OD1 . ASP A 1 201 ? 55.151 117.562 48.376 1.00 13.73 ? 201 ASP M OD1 1 ATOM 1591 O OD2 . ASP A 1 201 ? 53.769 116.268 49.459 1.00 13.19 ? 201 ASP M OD2 1 ATOM 1592 N N . ALA A 1 202 ? 58.525 114.701 50.441 1.00 6.87 ? 202 ALA M N 1 ATOM 1593 C CA . ALA A 1 202 ? 59.371 113.669 51.031 1.00 6.02 ? 202 ALA M CA 1 ATOM 1594 C C . ALA A 1 202 ? 58.700 112.333 50.705 1.00 6.12 ? 202 ALA M C 1 ATOM 1595 O O . ALA A 1 202 ? 57.472 112.251 50.650 1.00 7.18 ? 202 ALA M O 1 ATOM 1596 C CB . ALA A 1 202 ? 59.436 113.859 52.548 1.00 5.61 ? 202 ALA M CB 1 ATOM 1597 N N . PRO A 1 203 ? 59.488 111.261 50.524 1.00 6.59 ? 203 PRO M N 1 ATOM 1598 C CA . PRO A 1 203 ? 60.951 111.188 50.620 1.00 5.76 ? 203 PRO M CA 1 ATOM 1599 C C . PRO A 1 203 ? 61.713 111.770 49.426 1.00 7.87 ? 203 PRO M C 1 ATOM 1600 O O . PRO A 1 203 ? 62.940 111.886 49.470 1.00 10.25 ? 203 PRO M O 1 ATOM 1601 C CB . PRO A 1 203 ? 61.201 109.689 50.762 1.00 6.93 ? 203 PRO M CB 1 ATOM 1602 C CG . PRO A 1 203 ? 60.123 109.105 49.900 1.00 6.75 ? 203 PRO M CG 1 ATOM 1603 C CD . PRO A 1 203 ? 58.913 109.923 50.290 1.00 7.57 ? 203 PRO M CD 1 ATOM 1604 N N . GLY A 1 204 ? 60.997 112.112 48.358 1.00 7.62 ? 204 GLY M N 1 ATOM 1605 C CA . GLY A 1 204 ? 61.651 112.685 47.193 1.00 6.55 ? 204 GLY M CA 1 ATOM 1606 C C . GLY A 1 204 ? 62.211 111.669 46.210 1.00 7.67 ? 204 GLY M C 1 ATOM 1607 O O . GLY A 1 204 ? 63.312 111.839 45.693 1.00 8.70 ? 204 GLY M O 1 ATOM 1608 N N . ARG A 1 205 ? 61.459 110.603 45.967 1.00 7.29 ? 205 ARG M N 1 ATOM 1609 C CA . ARG A 1 205 ? 61.871 109.570 45.021 1.00 7.47 ? 205 ARG M CA 1 ATOM 1610 C C . ARG A 1 205 ? 61.133 109.749 43.696 1.00 6.87 ? 205 ARG M C 1 ATOM 1611 O O . ARG A 1 205 ? 59.985 110.195 43.669 1.00 8.47 ? 205 ARG M O 1 ATOM 1612 C CB . ARG A 1 205 ? 61.582 108.178 45.587 1.00 7.60 ? 205 ARG M CB 1 ATOM 1613 C CG . ARG A 1 205 ? 62.477 107.797 46.758 1.00 6.54 ? 205 ARG M CG 1 ATOM 1614 C CD . ARG A 1 205 ? 62.062 106.467 47.374 1.00 8.07 ? 205 ARG M CD 1 ATOM 1615 N NE . ARG A 1 205 ? 62.235 105.355 46.440 1.00 9.13 ? 205 ARG M NE 1 ATOM 1616 C CZ . ARG A 1 205 ? 63.317 104.580 46.380 1.00 10.42 ? 205 ARG M CZ 1 ATOM 1617 N NH1 . ARG A 1 205 ? 64.337 104.780 47.206 1.00 10.21 ? 205 ARG M NH1 1 ATOM 1618 N NH2 . ARG A 1 205 ? 63.387 103.606 45.483 1.00 8.92 ? 205 ARG M NH2 1 ATOM 1619 N N . CYS A 1 206 ? 61.811 109.427 42.599 1.00 7.36 ? 206 CYS M N 1 ATOM 1620 C CA . CYS A 1 206 ? 61.217 109.541 41.272 1.00 8.50 ? 206 CYS M CA 1 ATOM 1621 C C . CYS A 1 206 ? 62.144 108.921 40.240 1.00 8.54 ? 206 CYS M C 1 ATOM 1622 O O . CYS A 1 206 ? 63.254 108.507 40.569 1.00 8.81 ? 206 CYS M O 1 ATOM 1623 C CB . CYS A 1 206 ? 60.989 111.014 40.914 1.00 8.91 ? 206 CYS M CB 1 ATOM 1624 S SG . CYS A 1 206 ? 62.501 111.945 40.490 1.00 12.63 ? 206 CYS M SG 1 ATOM 1625 N N . SER A 1 207 ? 61.668 108.838 38.999 1.00 8.55 ? 207 SER M N 1 ATOM 1626 C CA . SER A 1 207 ? 62.477 108.304 37.906 1.00 9.86 ? 207 SER M CA 1 ATOM 1627 C C . SER A 1 207 ? 63.547 109.346 37.586 1.00 9.35 ? 207 SER M C 1 ATOM 1628 O O . SER A 1 207 ? 63.288 110.545 37.657 1.00 10.45 ? 207 SER M O 1 ATOM 1629 C CB . SER A 1 207 ? 61.610 108.066 36.671 1.00 10.46 ? 207 SER M CB 1 ATOM 1630 O OG . SER A 1 207 ? 60.637 107.070 36.920 1.00 10.75 ? 207 SER M OG 1 ATOM 1631 N N . PRO A 1 208 ? 64.755 108.899 37.199 1.00 12.96 ? 208 PRO M N 1 ATOM 1632 C CA . PRO A 1 208 ? 65.875 109.785 36.867 1.00 15.68 ? 208 PRO M CA 1 ATOM 1633 C C . PRO A 1 208 ? 65.556 110.951 35.932 1.00 15.73 ? 208 PRO M C 1 ATOM 1634 O O . PRO A 1 208 ? 66.015 112.069 36.160 1.00 17.12 ? 208 PRO M O 1 ATOM 1635 C CB . PRO A 1 208 ? 66.880 108.827 36.234 1.00 16.23 ? 208 PRO M CB 1 ATOM 1636 C CG . PRO A 1 208 ? 66.664 107.582 37.000 1.00 16.68 ? 208 PRO M CG 1 ATOM 1637 C CD . PRO A 1 208 ? 65.150 107.490 37.036 1.00 13.46 ? 208 PRO M CD 1 ATOM 1638 N N . THR A 1 209 ? 64.775 110.696 34.885 1.00 15.63 ? 209 THR M N 1 ATOM 1639 C CA . THR A 1 209 ? 64.438 111.750 33.931 1.00 16.40 ? 209 THR M CA 1 ATOM 1640 C C . THR A 1 209 ? 63.302 112.673 34.361 1.00 15.63 ? 209 THR M C 1 ATOM 1641 O O . THR A 1 209 ? 63.073 113.709 33.738 1.00 18.16 ? 209 THR M O 1 ATOM 1642 C CB . THR A 1 209 ? 64.164 111.188 32.517 1.00 18.48 ? 209 THR M CB 1 ATOM 1643 O OG1 . THR A 1 209 ? 63.036 110.310 32.553 1.00 20.92 ? 209 THR M OG1 1 ATOM 1644 C CG2 . THR A 1 209 ? 65.380 110.431 32.004 1.00 18.50 ? 209 THR M CG2 1 ATOM 1645 N N . VAL A 1 210 ? 62.574 112.291 35.407 1.00 14.25 ? 210 VAL M N 1 ATOM 1646 C CA . VAL A 1 210 ? 61.494 113.130 35.923 1.00 13.14 ? 210 VAL M CA 1 ATOM 1647 C C . VAL A 1 210 ? 62.141 114.274 36.703 1.00 14.19 ? 210 VAL M C 1 ATOM 1648 O O . VAL A 1 210 ? 61.752 115.435 36.567 1.00 15.18 ? 210 VAL M O 1 ATOM 1649 C CB . VAL A 1 210 ? 60.542 112.333 36.849 1.00 12.30 ? 210 VAL M CB 1 ATOM 1650 C CG1 . VAL A 1 210 ? 59.576 113.275 37.563 1.00 13.87 ? 210 VAL M CG1 1 ATOM 1651 C CG2 . VAL A 1 210 ? 59.758 111.314 36.032 1.00 13.40 ? 210 VAL M CG2 1 ATOM 1652 N N . ASP A 1 211 ? 63.149 113.932 37.501 1.00 13.09 ? 211 ASP M N 1 ATOM 1653 C CA . ASP A 1 211 ? 63.890 114.907 38.296 1.00 15.09 ? 211 ASP M CA 1 ATOM 1654 C C . ASP A 1 211 ? 65.231 114.285 38.666 1.00 13.75 ? 211 ASP M C 1 ATOM 1655 O O . ASP A 1 211 ? 65.292 113.373 39.483 1.00 13.85 ? 211 ASP M O 1 ATOM 1656 C CB . ASP A 1 211 ? 63.111 115.275 39.565 1.00 16.37 ? 211 ASP M CB 1 ATOM 1657 C CG . ASP A 1 211 ? 63.777 116.385 40.374 1.00 18.92 ? 211 ASP M CG 1 ATOM 1658 O OD1 . ASP A 1 211 ? 64.926 116.776 40.078 1.00 19.73 ? 211 ASP M OD1 1 ATOM 1659 O OD2 . ASP A 1 211 ? 63.139 116.873 41.325 1.00 21.04 ? 211 ASP M OD2 1 ATOM 1660 N N . PRO A 1 212 ? 66.326 114.785 38.071 1.00 15.09 ? 212 PRO M N 1 ATOM 1661 C CA . PRO A 1 212 ? 67.680 114.285 38.327 1.00 15.05 ? 212 PRO M CA 1 ATOM 1662 C C . PRO A 1 212 ? 68.113 114.375 39.789 1.00 14.18 ? 212 PRO M C 1 ATOM 1663 O O . PRO A 1 212 ? 69.029 113.668 40.209 1.00 17.18 ? 212 PRO M O 1 ATOM 1664 C CB . PRO A 1 212 ? 68.546 115.184 37.439 1.00 17.01 ? 212 PRO M CB 1 ATOM 1665 C CG . PRO A 1 212 ? 67.637 115.514 36.307 1.00 21.79 ? 212 PRO M CG 1 ATOM 1666 C CD . PRO A 1 212 ? 66.352 115.832 37.034 1.00 20.75 ? 212 PRO M CD 1 ATOM 1667 N N . SER A 1 213 ? 67.446 115.226 40.564 1.00 14.69 ? 213 SER M N 1 ATOM 1668 C CA . SER A 1 213 ? 67.793 115.386 41.972 1.00 15.39 ? 213 SER M CA 1 ATOM 1669 C C . SER A 1 213 ? 67.350 114.220 42.852 1.00 14.75 ? 213 SER M C 1 ATOM 1670 O O . SER A 1 213 ? 67.918 114.013 43.922 1.00 15.35 ? 213 SER M O 1 ATOM 1671 C CB . SER A 1 213 ? 67.261 116.709 42.531 1.00 18.25 ? 213 SER M CB 1 ATOM 1672 O OG . SER A 1 213 ? 65.859 116.679 42.716 1.00 22.09 ? 213 SER M OG 1 ATOM 1673 N N . CYS A 1 214 ? 66.354 113.451 42.410 1.00 12.57 ? 214 CYS M N 1 ATOM 1674 C CA . CYS A 1 214 ? 65.888 112.310 43.206 1.00 10.80 ? 214 CYS M CA 1 ATOM 1675 C C . CYS A 1 214 ? 67.044 111.344 43.434 1.00 12.14 ? 214 CYS M C 1 ATOM 1676 O O . CYS A 1 214 ? 67.823 111.070 42.517 1.00 11.87 ? 214 CYS M O 1 ATOM 1677 C CB . CYS A 1 214 ? 64.733 111.573 42.521 1.00 12.31 ? 214 CYS M CB 1 ATOM 1678 S SG . CYS A 1 214 ? 63.256 112.602 42.259 1.00 15.10 ? 214 CYS M SG 1 ATOM 1679 N N . TYR A 1 215 ? 67.160 110.838 44.657 1.00 9.38 ? 215 TYR M N 1 ATOM 1680 C CA . TYR A 1 215 ? 68.245 109.919 44.989 1.00 9.63 ? 215 TYR M CA 1 ATOM 1681 C C . TYR A 1 215 ? 68.036 108.516 44.430 1.00 10.07 ? 215 TYR M C 1 ATOM 1682 O O . TYR A 1 215 ? 68.992 107.756 44.262 1.00 10.63 ? 215 TYR M O 1 ATOM 1683 C CB . TYR A 1 215 ? 68.476 109.877 46.504 1.00 9.12 ? 215 TYR M CB 1 ATOM 1684 C CG . TYR A 1 215 ? 67.321 109.346 47.325 1.00 8.70 ? 215 TYR M CG 1 ATOM 1685 C CD1 . TYR A 1 215 ? 66.273 110.184 47.714 1.00 9.91 ? 215 TYR M CD1 1 ATOM 1686 C CD2 . TYR A 1 215 ? 67.293 108.017 47.746 1.00 11.27 ? 215 TYR M CD2 1 ATOM 1687 C CE1 . TYR A 1 215 ? 65.231 109.709 48.513 1.00 11.84 ? 215 TYR M CE1 1 ATOM 1688 C CE2 . TYR A 1 215 ? 66.256 107.532 48.546 1.00 10.20 ? 215 TYR M CE2 1 ATOM 1689 C CZ . TYR A 1 215 ? 65.231 108.384 48.923 1.00 10.34 ? 215 TYR M CZ 1 ATOM 1690 O OH . TYR A 1 215 ? 64.216 107.923 49.724 1.00 10.93 ? 215 TYR M OH 1 ATOM 1691 N N . ALA A 1 216 ? 66.779 108.191 44.140 1.00 9.43 ? 216 ALA M N 1 ATOM 1692 C CA . ALA A 1 216 ? 66.387 106.894 43.595 1.00 8.33 ? 216 ALA M CA 1 ATOM 1693 C C . ALA A 1 216 ? 64.902 106.952 43.289 1.00 8.24 ? 216 ALA M C 1 ATOM 1694 O O . ALA A 1 216 ? 64.247 107.960 43.558 1.00 8.41 ? 216 ALA M O 1 ATOM 1695 C CB . ALA A 1 216 ? 66.651 105.781 44.617 1.00 10.55 ? 216 ALA M CB 1 ATOM 1696 N N . GLY A 1 217 ? 64.380 105.888 42.687 1.00 8.99 ? 217 GLY M N 1 ATOM 1697 C CA . GLY A 1 217 ? 62.958 105.859 42.417 1.00 9.23 ? 217 GLY M CA 1 ATOM 1698 C C . GLY A 1 217 ? 62.527 105.415 41.041 1.00 10.41 ? 217 GLY M C 1 ATOM 1699 O O . GLY A 1 217 ? 63.341 105.140 40.159 1.00 9.94 ? 217 GLY M O 1 ATOM 1700 N N . ASN A 1 218 ? 61.211 105.352 40.880 1.00 9.34 ? 218 ASN M N 1 ATOM 1701 C CA . ASN A 1 218 ? 60.572 104.967 39.635 1.00 8.80 ? 218 ASN M CA 1 ATOM 1702 C C . ASN A 1 218 ? 59.158 105.518 39.748 1.00 7.45 ? 218 ASN M C 1 ATOM 1703 O O . ASN A 1 218 ? 58.304 104.943 40.425 1.00 8.87 ? 218 ASN M O 1 ATOM 1704 C CB . ASN A 1 218 ? 60.551 103.450 39.491 1.00 10.26 ? 218 ASN M CB 1 ATOM 1705 C CG . ASN A 1 218 ? 60.024 103.007 38.151 1.00 10.28 ? 218 ASN M CG 1 ATOM 1706 O OD1 . ASN A 1 218 ? 59.067 103.582 37.625 1.00 8.82 ? 218 ASN M OD1 1 ATOM 1707 N ND2 . ASN A 1 218 ? 60.661 101.985 37.593 1.00 12.41 ? 218 ASN M ND2 1 ATOM 1708 N N . SER A 1 219 ? 58.930 106.644 39.081 1.00 7.16 ? 219 SER M N 1 ATOM 1709 C CA . SER A 1 219 ? 57.649 107.340 39.115 1.00 8.08 ? 219 SER M CA 1 ATOM 1710 C C . SER A 1 219 ? 56.477 106.556 38.548 1.00 8.82 ? 219 SER M C 1 ATOM 1711 O O . SER A 1 219 ? 55.330 106.849 38.857 1.00 8.52 ? 219 SER M O 1 ATOM 1712 C CB . SER A 1 219 ? 57.771 108.661 38.361 1.00 9.63 ? 219 SER M CB 1 ATOM 1713 O OG . SER A 1 219 ? 58.818 109.445 38.894 1.00 9.70 ? 219 SER M OG 1 ATOM 1714 N N . SER A 1 220 ? 56.772 105.569 37.711 1.00 9.24 ? 220 SER M N 1 ATOM 1715 C CA . SER A 1 220 ? 55.735 104.765 37.078 1.00 9.69 ? 220 SER M CA 1 ATOM 1716 C C . SER A 1 220 ? 55.220 103.611 37.938 1.00 9.95 ? 220 SER M C 1 ATOM 1717 O O . SER A 1 220 ? 54.055 103.227 37.843 1.00 11.06 ? 220 SER M O 1 ATOM 1718 C CB . SER A 1 220 ? 56.268 104.224 35.743 1.00 9.93 ? 220 SER M CB 1 ATOM 1719 O OG . SER A 1 220 ? 55.253 103.557 35.013 1.00 14.88 ? 220 SER M OG 1 ATOM 1720 N N . THR A 1 221 ? 56.081 103.082 38.798 1.00 7.81 ? 221 THR M N 1 ATOM 1721 C CA . THR A 1 221 ? 55.727 101.945 39.633 1.00 8.52 ? 221 THR M CA 1 ATOM 1722 C C . THR A 1 221 ? 55.586 102.217 41.124 1.00 7.91 ? 221 THR M C 1 ATOM 1723 O O . THR A 1 221 ? 54.677 101.698 41.769 1.00 8.26 ? 221 THR M O 1 ATOM 1724 C CB . THR A 1 221 ? 56.775 100.836 39.493 1.00 10.45 ? 221 THR M CB 1 ATOM 1725 O OG1 . THR A 1 221 ? 58.069 101.368 39.811 1.00 10.13 ? 221 THR M OG1 1 ATOM 1726 C CG2 . THR A 1 221 ? 56.787 100.287 38.078 1.00 12.18 ? 221 THR M CG2 1 ATOM 1727 N N . GLU A 1 222 ? 56.501 103.007 41.672 1.00 8.28 ? 222 GLU M N 1 ATOM 1728 C CA . GLU A 1 222 ? 56.492 103.278 43.104 1.00 8.23 ? 222 GLU M CA 1 ATOM 1729 C C . GLU A 1 222 ? 55.223 103.876 43.708 1.00 6.92 ? 222 GLU M C 1 ATOM 1730 O O . GLU A 1 222 ? 54.831 103.488 44.807 1.00 7.72 ? 222 GLU M O 1 ATOM 1731 C CB . GLU A 1 222 ? 57.762 104.022 43.521 1.00 7.18 ? 222 GLU M CB 1 ATOM 1732 C CG . GLU A 1 222 ? 59.006 103.176 43.205 1.00 8.80 ? 222 GLU M CG 1 ATOM 1733 C CD . GLU A 1 222 ? 60.270 103.632 43.904 1.00 8.27 ? 222 GLU M CD 1 ATOM 1734 O OE1 . GLU A 1 222 ? 60.254 104.672 44.586 1.00 9.20 ? 222 GLU M OE1 1 ATOM 1735 O OE2 . GLU A 1 222 ? 61.296 102.927 43.772 1.00 9.85 ? 222 GLU M OE2 1 ATOM 1736 N N . PRO A 1 223 ? 54.564 104.817 43.012 1.00 6.15 ? 223 PRO M N 1 ATOM 1737 C CA . PRO A 1 223 ? 53.339 105.368 43.605 1.00 6.17 ? 223 PRO M CA 1 ATOM 1738 C C . PRO A 1 223 ? 52.297 104.273 43.885 1.00 7.19 ? 223 PRO M C 1 ATOM 1739 O O . PRO A 1 223 ? 51.598 104.315 44.895 1.00 5.92 ? 223 PRO M O 1 ATOM 1740 C CB . PRO A 1 223 ? 52.853 106.338 42.532 1.00 5.74 ? 223 PRO M CB 1 ATOM 1741 C CG . PRO A 1 223 ? 54.136 106.850 41.946 1.00 6.50 ? 223 PRO M CG 1 ATOM 1742 C CD . PRO A 1 223 ? 54.957 105.580 41.811 1.00 6.63 ? 223 PRO M CD 1 ATOM 1743 N N . TYR A 1 224 ? 52.225 103.267 43.015 1.00 6.84 ? 224 TYR M N 1 ATOM 1744 C CA . TYR A 1 224 ? 51.261 102.183 43.214 1.00 7.99 ? 224 TYR M CA 1 ATOM 1745 C C . TYR A 1 224 ? 51.649 101.271 44.366 1.00 6.70 ? 224 TYR M C 1 ATOM 1746 O O . TYR A 1 224 ? 50.792 100.810 45.112 1.00 7.61 ? 224 TYR M O 1 ATOM 1747 C CB . TYR A 1 224 ? 51.078 101.378 41.924 1.00 6.53 ? 224 TYR M CB 1 ATOM 1748 C CG . TYR A 1 224 ? 50.441 102.208 40.846 1.00 5.90 ? 224 TYR M CG 1 ATOM 1749 C CD1 . TYR A 1 224 ? 49.136 102.672 40.996 1.00 7.77 ? 224 TYR M CD1 1 ATOM 1750 C CD2 . TYR A 1 224 ? 51.161 102.605 39.719 1.00 7.95 ? 224 TYR M CD2 1 ATOM 1751 C CE1 . TYR A 1 224 ? 48.565 103.520 40.069 1.00 6.60 ? 224 TYR M CE1 1 ATOM 1752 C CE2 . TYR A 1 224 ? 50.594 103.459 38.777 1.00 8.06 ? 224 TYR M CE2 1 ATOM 1753 C CZ . TYR A 1 224 ? 49.293 103.913 38.966 1.00 7.31 ? 224 TYR M CZ 1 ATOM 1754 O OH . TYR A 1 224 ? 48.716 104.793 38.085 1.00 8.84 ? 224 TYR M OH 1 ATOM 1755 N N . ILE A 1 225 ? 52.945 101.007 44.499 1.00 7.06 ? 225 ILE M N 1 ATOM 1756 C CA . ILE A 1 225 ? 53.447 100.167 45.577 1.00 6.48 ? 225 ILE M CA 1 ATOM 1757 C C . ILE A 1 225 ? 53.192 100.861 46.915 1.00 6.32 ? 225 ILE M C 1 ATOM 1758 O O . ILE A 1 225 ? 52.683 100.250 47.855 1.00 6.71 ? 225 ILE M O 1 ATOM 1759 C CB . ILE A 1 225 ? 54.956 99.898 45.406 1.00 9.52 ? 225 ILE M CB 1 ATOM 1760 C CG1 . ILE A 1 225 ? 55.193 99.093 44.123 1.00 10.11 ? 225 ILE M CG1 1 ATOM 1761 C CG2 . ILE A 1 225 ? 55.505 99.140 46.611 1.00 10.85 ? 225 ILE M CG2 1 ATOM 1762 C CD1 . ILE A 1 225 ? 56.662 98.957 43.748 1.00 11.91 ? 225 ILE M CD1 1 ATOM 1763 N N . VAL A 1 226 ? 53.524 102.146 46.981 1.00 6.53 ? 226 VAL M N 1 ATOM 1764 C CA . VAL A 1 226 ? 53.329 102.926 48.201 1.00 6.30 ? 226 VAL M CA 1 ATOM 1765 C C . VAL A 1 226 ? 51.849 103.048 48.565 1.00 7.42 ? 226 VAL M C 1 ATOM 1766 O O . VAL A 1 226 ? 51.484 102.897 49.727 1.00 6.95 ? 226 VAL M O 1 ATOM 1767 C CB . VAL A 1 226 ? 53.979 104.309 48.071 1.00 6.65 ? 226 VAL M CB 1 ATOM 1768 C CG1 . VAL A 1 226 ? 53.641 105.195 49.275 1.00 7.40 ? 226 VAL M CG1 1 ATOM 1769 C CG2 . VAL A 1 226 ? 55.489 104.141 47.943 1.00 6.75 ? 226 VAL M CG2 1 ATOM 1770 N N . ALA A 1 227 ? 51.000 103.317 47.575 1.00 6.70 ? 227 ALA M N 1 ATOM 1771 C CA . ALA A 1 227 ? 49.558 103.436 47.814 1.00 6.26 ? 227 ALA M CA 1 ATOM 1772 C C . ALA A 1 227 ? 49.013 102.121 48.362 1.00 6.92 ? 227 ALA M C 1 ATOM 1773 O O . ALA A 1 227 ? 48.202 102.107 49.288 1.00 6.73 ? 227 ALA M O 1 ATOM 1774 C CB . ALA A 1 227 ? 48.844 103.793 46.527 1.00 5.61 ? 227 ALA M CB 1 ATOM 1775 N N . HIS A 1 228 ? 49.482 101.017 47.791 1.00 6.67 ? 228 HIS M N 1 ATOM 1776 C CA . HIS A 1 228 ? 49.058 99.690 48.210 1.00 6.70 ? 228 HIS M CA 1 ATOM 1777 C C . HIS A 1 228 ? 49.435 99.452 49.667 1.00 6.01 ? 228 HIS M C 1 ATOM 1778 O O . HIS A 1 228 ? 48.613 99.002 50.462 1.00 6.55 ? 228 HIS M O 1 ATOM 1779 C CB . HIS A 1 228 ? 49.713 98.634 47.321 1.00 6.29 ? 228 HIS M CB 1 ATOM 1780 C CG . HIS A 1 228 ? 49.068 97.288 47.405 1.00 9.04 ? 228 HIS M CG 1 ATOM 1781 N ND1 . HIS A 1 228 ? 47.823 97.029 46.873 1.00 9.32 ? 228 HIS M ND1 1 ATOM 1782 C CD2 . HIS A 1 228 ? 49.507 96.121 47.929 1.00 8.80 ? 228 HIS M CD2 1 ATOM 1783 C CE1 . HIS A 1 228 ? 47.526 95.756 47.063 1.00 10.40 ? 228 HIS M CE1 1 ATOM 1784 N NE2 . HIS A 1 228 ? 48.528 95.183 47.701 1.00 10.67 ? 228 HIS M NE2 1 ATOM 1785 N N . HIS A 1 229 ? 50.682 99.756 50.016 1.00 5.67 ? 229 HIS M N 1 ATOM 1786 C CA . HIS A 1 229 ? 51.137 99.569 51.391 1.00 6.71 ? 229 HIS M CA 1 ATOM 1787 C C . HIS A 1 229 ? 50.423 100.491 52.361 1.00 6.41 ? 229 HIS M C 1 ATOM 1788 O O . HIS A 1 229 ? 50.205 100.124 53.513 1.00 7.66 ? 229 HIS M O 1 ATOM 1789 C CB . HIS A 1 229 ? 52.649 99.735 51.489 1.00 7.50 ? 229 HIS M CB 1 ATOM 1790 C CG . HIS A 1 229 ? 53.405 98.647 50.803 1.00 7.95 ? 229 HIS M CG 1 ATOM 1791 N ND1 . HIS A 1 229 ? 54.677 98.822 50.301 1.00 9.60 ? 229 HIS M ND1 1 ATOM 1792 C CD2 . HIS A 1 229 ? 53.060 97.369 50.512 1.00 12.37 ? 229 HIS M CD2 1 ATOM 1793 C CE1 . HIS A 1 229 ? 55.080 97.702 49.729 1.00 9.58 ? 229 HIS M CE1 1 ATOM 1794 N NE2 . HIS A 1 229 ? 54.116 96.804 49.844 1.00 11.99 ? 229 HIS M NE2 1 ATOM 1795 N N . GLN A 1 230 ? 50.070 101.692 51.900 1.00 7.06 ? 230 GLN M N 1 ATOM 1796 C CA . GLN A 1 230 ? 49.329 102.626 52.744 1.00 6.53 ? 230 GLN M CA 1 ATOM 1797 C C . GLN A 1 230 ? 47.979 102.009 53.085 1.00 7.04 ? 230 GLN M C 1 ATOM 1798 O O . GLN A 1 230 ? 47.552 102.023 54.237 1.00 7.41 ? 230 GLN M O 1 ATOM 1799 C CB . GLN A 1 230 ? 49.090 103.953 52.025 1.00 6.30 ? 230 GLN M CB 1 ATOM 1800 C CG . GLN A 1 230 ? 50.306 104.859 51.971 1.00 7.87 ? 230 GLN M CG 1 ATOM 1801 C CD . GLN A 1 230 ? 49.969 106.233 51.428 1.00 11.43 ? 230 GLN M CD 1 ATOM 1802 O OE1 . GLN A 1 230 ? 50.642 107.212 51.734 1.00 10.62 ? 230 GLN M OE1 1 ATOM 1803 N NE2 . GLN A 1 230 ? 48.918 106.311 50.617 1.00 11.12 ? 230 GLN M NE2 1 ATOM 1804 N N . LEU A 1 231 ? 47.308 101.456 52.079 1.00 6.94 ? 231 LEU M N 1 ATOM 1805 C CA . LEU A 1 231 ? 46.011 100.831 52.305 1.00 6.43 ? 231 LEU M CA 1 ATOM 1806 C C . LEU A 1 231 ? 46.113 99.650 53.265 1.00 6.87 ? 231 LEU M C 1 ATOM 1807 O O . LEU A 1 231 ? 45.289 99.511 54.168 1.00 7.72 ? 231 LEU M O 1 ATOM 1808 C CB . LEU A 1 231 ? 45.384 100.404 50.976 1.00 6.60 ? 231 LEU M CB 1 ATOM 1809 C CG . LEU A 1 231 ? 44.815 101.563 50.151 1.00 6.70 ? 231 LEU M CG 1 ATOM 1810 C CD1 . LEU A 1 231 ? 44.589 101.118 48.708 1.00 8.43 ? 231 LEU M CD1 1 ATOM 1811 C CD2 . LEU A 1 231 ? 43.512 102.049 50.776 1.00 8.17 ? 231 LEU M CD2 1 ATOM 1812 N N . LEU A 1 232 ? 47.137 98.820 53.083 1.00 7.11 ? 232 LEU M N 1 ATOM 1813 C CA . LEU A 1 232 ? 47.341 97.664 53.949 1.00 7.46 ? 232 LEU M CA 1 ATOM 1814 C C . LEU A 1 232 ? 47.699 98.094 55.368 1.00 8.29 ? 232 LEU M C 1 ATOM 1815 O O . LEU A 1 232 ? 47.184 97.529 56.329 1.00 7.78 ? 232 LEU M O 1 ATOM 1816 C CB . LEU A 1 232 ? 48.432 96.751 53.391 1.00 7.66 ? 232 LEU M CB 1 ATOM 1817 C CG . LEU A 1 232 ? 48.129 96.066 52.057 1.00 9.90 ? 232 LEU M CG 1 ATOM 1818 C CD1 . LEU A 1 232 ? 49.321 95.233 51.624 1.00 10.37 ? 232 LEU M CD1 1 ATOM 1819 C CD2 . LEU A 1 232 ? 46.887 95.199 52.180 1.00 10.55 ? 232 LEU M CD2 1 ATOM 1820 N N . ALA A 1 233 ? 48.581 99.087 55.493 1.00 7.57 ? 233 ALA M N 1 ATOM 1821 C CA . ALA A 1 233 ? 48.998 99.594 56.805 1.00 8.53 ? 233 ALA M CA 1 ATOM 1822 C C . ALA A 1 233 ? 47.788 100.197 57.512 1.00 8.07 ? 233 ALA M C 1 ATOM 1823 O O . ALA A 1 233 ? 47.537 99.928 58.687 1.00 7.64 ? 233 ALA M O 1 ATOM 1824 C CB . ALA A 1 233 ? 50.096 100.642 56.647 1.00 9.12 ? 233 ALA M CB 1 ATOM 1825 N N . HIS A 1 234 ? 47.049 101.026 56.784 1.00 7.47 ? 234 HIS M N 1 ATOM 1826 C CA . HIS A 1 234 ? 45.842 101.646 57.316 1.00 7.26 ? 234 HIS M CA 1 ATOM 1827 C C . HIS A 1 234 ? 44.858 100.574 57.799 1.00 8.49 ? 234 HIS M C 1 ATOM 1828 O O . HIS A 1 234 ? 44.332 100.655 58.906 1.00 7.94 ? 234 HIS M O 1 ATOM 1829 C CB . HIS A 1 234 ? 45.173 102.504 56.232 1.00 7.56 ? 234 HIS M CB 1 ATOM 1830 C CG . HIS A 1 234 ? 43.690 102.629 56.397 1.00 5.90 ? 234 HIS M CG 1 ATOM 1831 N ND1 . HIS A 1 234 ? 43.110 103.574 57.217 1.00 6.46 ? 234 HIS M ND1 1 ATOM 1832 C CD2 . HIS A 1 234 ? 42.673 101.882 55.909 1.00 6.54 ? 234 HIS M CD2 1 ATOM 1833 C CE1 . HIS A 1 234 ? 41.804 103.397 57.234 1.00 8.37 ? 234 HIS M CE1 1 ATOM 1834 N NE2 . HIS A 1 234 ? 41.510 102.374 56.449 1.00 7.54 ? 234 HIS M NE2 1 ATOM 1835 N N . ALA A 1 235 ? 44.613 99.581 56.948 1.00 7.90 ? 235 ALA M N 1 ATOM 1836 C CA . ALA A 1 235 ? 43.670 98.511 57.265 1.00 9.69 ? 235 ALA M CA 1 ATOM 1837 C C . ALA A 1 235 ? 44.084 97.677 58.470 1.00 7.75 ? 235 ALA M C 1 ATOM 1838 O O . ALA A 1 235 ? 43.240 97.278 59.267 1.00 8.64 ? 235 ALA M O 1 ATOM 1839 C CB . ALA A 1 235 ? 43.468 97.619 56.055 1.00 9.63 ? 235 ALA M CB 1 ATOM 1840 N N . LYS A 1 236 ? 45.383 97.423 58.600 1.00 7.98 ? 236 LYS M N 1 ATOM 1841 C CA . LYS A 1 236 ? 45.901 96.637 59.718 1.00 8.92 ? 236 LYS M CA 1 ATOM 1842 C C . LYS A 1 236 ? 45.661 97.404 61.014 1.00 10.41 ? 236 LYS M C 1 ATOM 1843 O O . LYS A 1 236 ? 45.305 96.822 62.044 1.00 9.05 ? 236 LYS M O 1 ATOM 1844 C CB . LYS A 1 236 ? 47.399 96.389 59.531 1.00 10.96 ? 236 LYS M CB 1 ATOM 1845 C CG . LYS A 1 236 ? 47.971 95.287 60.407 1.00 21.69 ? 236 LYS M CG 1 ATOM 1846 C CD . LYS A 1 236 ? 47.457 93.922 59.973 1.00 26.97 ? 236 LYS M CD 1 ATOM 1847 C CE . LYS A 1 236 ? 48.052 92.810 60.823 1.00 30.70 ? 236 LYS M CE 1 ATOM 1848 N NZ . LYS A 1 236 ? 47.535 91.476 60.406 1.00 34.87 ? 236 LYS M NZ 1 ATOM 1849 N N . VAL A 1 237 ? 45.846 98.718 60.949 1.00 8.67 ? 237 VAL M N 1 ATOM 1850 C CA . VAL A 1 237 ? 45.646 99.579 62.110 1.00 8.02 ? 237 VAL M CA 1 ATOM 1851 C C . VAL A 1 237 ? 44.173 99.681 62.495 1.00 8.09 ? 237 VAL M C 1 ATOM 1852 O O . VAL A 1 237 ? 43.838 99.677 63.681 1.00 8.67 ? 237 VAL M O 1 ATOM 1853 C CB . VAL A 1 237 ? 46.255 100.973 61.872 1.00 7.63 ? 237 VAL M CB 1 ATOM 1854 C CG1 . VAL A 1 237 ? 45.774 101.964 62.928 1.00 8.55 ? 237 VAL M CG1 1 ATOM 1855 C CG2 . VAL A 1 237 ? 47.778 100.869 61.908 1.00 10.80 ? 237 VAL M CG2 1 ATOM 1856 N N . VAL A 1 238 ? 43.291 99.768 61.502 1.00 7.25 ? 238 VAL M N 1 ATOM 1857 C CA . VAL A 1 238 ? 41.860 99.844 61.785 1.00 6.83 ? 238 VAL M CA 1 ATOM 1858 C C . VAL A 1 238 ? 41.400 98.526 62.413 1.00 5.84 ? 238 VAL M C 1 ATOM 1859 O O . VAL A 1 238 ? 40.610 98.520 63.357 1.00 8.81 ? 238 VAL M O 1 ATOM 1860 C CB . VAL A 1 238 ? 41.046 100.154 60.513 1.00 6.85 ? 238 VAL M CB 1 ATOM 1861 C CG1 . VAL A 1 238 ? 39.550 100.004 60.784 1.00 8.88 ? 238 VAL M CG1 1 ATOM 1862 C CG2 . VAL A 1 238 ? 41.346 101.577 60.054 1.00 7.72 ? 238 VAL M CG2 1 ATOM 1863 N N . ASP A 1 239 ? 41.923 97.415 61.899 1.00 8.64 ? 239 ASP M N 1 ATOM 1864 C CA . ASP A 1 239 ? 41.592 96.093 62.424 1.00 9.42 ? 239 ASP M CA 1 ATOM 1865 C C . ASP A 1 239 ? 42.045 95.997 63.883 1.00 10.34 ? 239 ASP M C 1 ATOM 1866 O O . ASP A 1 239 ? 41.323 95.476 64.739 1.00 9.61 ? 239 ASP M O 1 ATOM 1867 C CB . ASP A 1 239 ? 42.280 95.012 61.581 1.00 10.11 ? 239 ASP M CB 1 ATOM 1868 C CG . ASP A 1 239 ? 41.986 93.610 62.072 1.00 18.52 ? 239 ASP M CG 1 ATOM 1869 O OD1 . ASP A 1 239 ? 40.844 93.153 61.894 1.00 16.56 ? 239 ASP M OD1 1 ATOM 1870 O OD2 . ASP A 1 239 ? 42.899 92.966 62.629 1.00 24.77 ? 239 ASP M OD2 1 ATOM 1871 N N . LEU A 1 240 ? 43.246 96.501 64.157 1.00 8.94 ? 240 LEU M N 1 ATOM 1872 C CA . LEU A 1 240 ? 43.804 96.494 65.510 1.00 9.07 ? 240 LEU M CA 1 ATOM 1873 C C . LEU A 1 240 ? 42.917 97.320 66.433 1.00 8.99 ? 240 LEU M C 1 ATOM 1874 O O . LEU A 1 240 ? 42.585 96.899 67.541 1.00 9.84 ? 240 LEU M O 1 ATOM 1875 C CB . LEU A 1 240 ? 45.210 97.099 65.509 1.00 10.23 ? 240 LEU M CB 1 ATOM 1876 C CG . LEU A 1 240 ? 45.802 97.471 66.877 1.00 12.30 ? 240 LEU M CG 1 ATOM 1877 C CD1 . LEU A 1 240 ? 46.097 96.221 67.689 1.00 14.77 ? 240 LEU M CD1 1 ATOM 1878 C CD2 . LEU A 1 240 ? 47.069 98.290 66.676 1.00 14.92 ? 240 LEU M CD2 1 ATOM 1879 N N . TYR A 1 241 ? 42.537 98.502 65.961 1.00 7.42 ? 241 TYR M N 1 ATOM 1880 C CA . TYR A 1 241 ? 41.704 99.398 66.751 1.00 6.79 ? 241 TYR M CA 1 ATOM 1881 C C . TYR A 1 241 ? 40.347 98.791 67.082 1.00 9.46 ? 241 TYR M C 1 ATOM 1882 O O . TYR A 1 241 ? 39.908 98.811 68.234 1.00 9.82 ? 241 TYR M O 1 ATOM 1883 C CB . TYR A 1 241 ? 41.496 100.724 66.012 1.00 8.39 ? 241 TYR M CB 1 ATOM 1884 C CG . TYR A 1 241 ? 40.769 101.751 66.841 1.00 7.81 ? 241 TYR M CG 1 ATOM 1885 C CD1 . TYR A 1 241 ? 41.392 102.347 67.936 1.00 6.59 ? 241 TYR M CD1 1 ATOM 1886 C CD2 . TYR A 1 241 ? 39.454 102.110 66.551 1.00 8.86 ? 241 TYR M CD2 1 ATOM 1887 C CE1 . TYR A 1 241 ? 40.726 103.273 68.725 1.00 9.15 ? 241 TYR M CE1 1 ATOM 1888 C CE2 . TYR A 1 241 ? 38.777 103.041 67.335 1.00 9.97 ? 241 TYR M CE2 1 ATOM 1889 C CZ . TYR A 1 241 ? 39.421 103.613 68.419 1.00 10.57 ? 241 TYR M CZ 1 ATOM 1890 O OH . TYR A 1 241 ? 38.763 104.519 69.206 1.00 11.35 ? 241 TYR M OH 1 ATOM 1891 N N . ARG A 1 242 ? 39.703 98.216 66.076 1.00 9.73 ? 242 ARG M N 1 ATOM 1892 C CA . ARG A 1 242 ? 38.379 97.646 66.277 1.00 10.23 ? 242 ARG M CA 1 ATOM 1893 C C . ARG A 1 242 ? 38.346 96.304 66.995 1.00 13.29 ? 242 ARG M C 1 ATOM 1894 O O . ARG A 1 242 ? 37.331 95.942 67.587 1.00 14.56 ? 242 ARG M O 1 ATOM 1895 C CB . ARG A 1 242 ? 37.605 97.635 64.954 1.00 13.70 ? 242 ARG M CB 1 ATOM 1896 C CG . ARG A 1 242 ? 37.491 99.055 64.384 1.00 13.72 ? 242 ARG M CG 1 ATOM 1897 C CD . ARG A 1 242 ? 36.392 99.235 63.354 1.00 18.72 ? 242 ARG M CD 1 ATOM 1898 N NE . ARG A 1 242 ? 36.683 98.537 62.114 1.00 14.49 ? 242 ARG M NE 1 ATOM 1899 C CZ . ARG A 1 242 ? 36.113 98.806 60.943 1.00 12.26 ? 242 ARG M CZ 1 ATOM 1900 N NH1 . ARG A 1 242 ? 35.217 99.778 60.827 1.00 13.28 ? 242 ARG M NH1 1 ATOM 1901 N NH2 . ARG A 1 242 ? 36.400 98.053 59.897 1.00 10.58 ? 242 ARG M NH2 1 ATOM 1902 N N . LYS A 1 243 ? 39.473 95.603 67.018 1.00 11.02 ? 243 LYS M N 1 ATOM 1903 C CA . LYS A 1 243 ? 39.524 94.314 67.699 1.00 13.15 ? 243 LYS M CA 1 ATOM 1904 C C . LYS A 1 243 ? 40.114 94.373 69.100 1.00 14.55 ? 243 LYS M C 1 ATOM 1905 O O . LYS A 1 243 ? 39.692 93.627 69.982 1.00 12.41 ? 243 LYS M O 1 ATOM 1906 C CB . LYS A 1 243 ? 40.273 93.286 66.858 1.00 15.08 ? 243 LYS M CB 1 ATOM 1907 C CG . LYS A 1 243 ? 39.442 92.762 65.704 1.00 18.27 ? 243 LYS M CG 1 ATOM 1908 C CD . LYS A 1 243 ? 40.190 91.732 64.902 1.00 21.39 ? 243 LYS M CD 1 ATOM 1909 C CE . LYS A 1 243 ? 39.310 91.178 63.798 1.00 21.77 ? 243 LYS M CE 1 ATOM 1910 N NZ . LYS A 1 243 ? 40.105 90.335 62.873 1.00 24.63 ? 243 LYS M NZ 1 ATOM 1911 N N . ASN A 1 244 ? 41.070 95.272 69.310 1.00 13.09 ? 244 ASN M N 1 ATOM 1912 C CA . ASN A 1 244 ? 41.721 95.391 70.613 1.00 13.57 ? 244 ASN M CA 1 ATOM 1913 C C . ASN A 1 244 ? 41.403 96.642 71.419 1.00 13.06 ? 244 ASN M C 1 ATOM 1914 O O . ASN A 1 244 ? 41.731 96.708 72.607 1.00 12.69 ? 244 ASN M O 1 ATOM 1915 C CB . ASN A 1 244 ? 43.237 95.256 70.462 1.00 15.24 ? 244 ASN M CB 1 ATOM 1916 C CG . ASN A 1 244 ? 43.666 93.840 70.139 1.00 23.92 ? 244 ASN M CG 1 ATOM 1917 O OD1 . ASN A 1 244 ? 42.834 92.944 70.015 1.00 26.42 ? 244 ASN M OD1 1 ATOM 1918 N ND2 . ASN A 1 244 ? 44.970 93.631 70.017 1.00 29.86 ? 244 ASN M ND2 1 ATOM 1919 N N . TYR A 1 245 ? 40.782 97.633 70.786 1.00 9.12 ? 245 TYR M N 1 ATOM 1920 C CA . TYR A 1 245 ? 40.457 98.873 71.483 1.00 8.28 ? 245 TYR M CA 1 ATOM 1921 C C . TYR A 1 245 ? 38.994 99.293 71.400 1.00 8.45 ? 245 TYR M C 1 ATOM 1922 O O . TYR A 1 245 ? 38.670 100.459 71.608 1.00 9.97 ? 245 TYR M O 1 ATOM 1923 C CB . TYR A 1 245 ? 41.376 100.002 70.990 1.00 7.77 ? 245 TYR M CB 1 ATOM 1924 C CG . TYR A 1 245 ? 42.817 99.757 71.359 1.00 9.24 ? 245 TYR M CG 1 ATOM 1925 C CD1 . TYR A 1 245 ? 43.293 100.098 72.625 1.00 10.48 ? 245 TYR M CD1 1 ATOM 1926 C CD2 . TYR A 1 245 ? 43.684 99.115 70.478 1.00 8.72 ? 245 TYR M CD2 1 ATOM 1927 C CE1 . TYR A 1 245 ? 44.590 99.799 73.007 1.00 9.60 ? 245 TYR M CE1 1 ATOM 1928 C CE2 . TYR A 1 245 ? 44.993 98.810 70.852 1.00 9.07 ? 245 TYR M CE2 1 ATOM 1929 C CZ . TYR A 1 245 ? 45.435 99.153 72.120 1.00 11.35 ? 245 TYR M CZ 1 ATOM 1930 O OH . TYR A 1 245 ? 46.712 98.831 72.516 1.00 12.57 ? 245 TYR M OH 1 ATOM 1931 N N . THR A 1 246 ? 38.100 98.336 71.152 1.00 9.60 ? 246 THR M N 1 ATOM 1932 C CA . THR A 1 246 ? 36.680 98.662 71.057 1.00 12.33 ? 246 THR M CA 1 ATOM 1933 C C . THR A 1 246 ? 36.125 99.160 72.393 1.00 10.49 ? 246 THR M C 1 ATOM 1934 O O . THR A 1 246 ? 35.107 99.847 72.432 1.00 12.43 ? 246 THR M O 1 ATOM 1935 C CB . THR A 1 246 ? 35.843 97.470 70.528 1.00 15.69 ? 246 THR M CB 1 ATOM 1936 O OG1 . THR A 1 246 ? 34.491 97.889 70.317 1.00 26.44 ? 246 THR M OG1 1 ATOM 1937 C CG2 . THR A 1 246 ? 35.841 96.340 71.503 1.00 16.44 ? 246 THR M CG2 1 ATOM 1938 N N . HIS A 1 247 ? 36.822 98.842 73.480 1.00 11.50 ? 247 HIS M N 1 ATOM 1939 C CA . HIS A 1 247 ? 36.398 99.282 74.807 1.00 12.38 ? 247 HIS M CA 1 ATOM 1940 C C . HIS A 1 247 ? 36.514 100.799 74.962 1.00 12.08 ? 247 HIS M C 1 ATOM 1941 O O . HIS A 1 247 ? 35.889 101.390 75.842 1.00 12.11 ? 247 HIS M O 1 ATOM 1942 C CB . HIS A 1 247 ? 37.222 98.585 75.894 1.00 12.85 ? 247 HIS M CB 1 ATOM 1943 C CG . HIS A 1 247 ? 38.684 98.903 75.848 1.00 12.57 ? 247 HIS M CG 1 ATOM 1944 N ND1 . HIS A 1 247 ? 39.565 98.240 75.022 1.00 13.49 ? 247 HIS M ND1 1 ATOM 1945 C CD2 . HIS A 1 247 ? 39.421 99.809 76.535 1.00 15.21 ? 247 HIS M CD2 1 ATOM 1946 C CE1 . HIS A 1 247 ? 40.782 98.722 75.202 1.00 15.98 ? 247 HIS M CE1 1 ATOM 1947 N NE2 . HIS A 1 247 ? 40.722 99.674 76.115 1.00 14.34 ? 247 HIS M NE2 1 ATOM 1948 N N . GLN A 1 248 ? 37.312 101.427 74.101 1.00 11.52 ? 248 GLN M N 1 ATOM 1949 C CA . GLN A 1 248 ? 37.498 102.875 74.160 1.00 10.04 ? 248 GLN M CA 1 ATOM 1950 C C . GLN A 1 248 ? 36.323 103.644 73.562 1.00 10.47 ? 248 GLN M C 1 ATOM 1951 O O . GLN A 1 248 ? 36.191 104.845 73.776 1.00 11.89 ? 248 GLN M O 1 ATOM 1952 C CB . GLN A 1 248 ? 38.819 103.271 73.498 1.00 10.38 ? 248 GLN M CB 1 ATOM 1953 C CG . GLN A 1 248 ? 40.023 102.664 74.205 1.00 9.28 ? 248 GLN M CG 1 ATOM 1954 C CD . GLN A 1 248 ? 41.348 103.081 73.606 1.00 11.15 ? 248 GLN M CD 1 ATOM 1955 O OE1 . GLN A 1 248 ? 41.425 103.463 72.440 1.00 10.82 ? 248 GLN M OE1 1 ATOM 1956 N NE2 . GLN A 1 248 ? 42.402 103.013 74.408 1.00 10.68 ? 248 GLN M NE2 1 ATOM 1957 N N . GLY A 1 249 ? 35.471 102.942 72.817 1.00 10.95 ? 249 GLY M N 1 ATOM 1958 C CA . GLY A 1 249 ? 34.296 103.564 72.230 1.00 12.41 ? 249 GLY M CA 1 ATOM 1959 C C . GLY A 1 249 ? 34.565 104.706 71.275 1.00 11.93 ? 249 GLY M C 1 ATOM 1960 O O . GLY A 1 249 ? 33.808 105.675 71.226 1.00 13.38 ? 249 GLY M O 1 ATOM 1961 N N . GLY A 1 250 ? 35.648 104.592 70.518 1.00 9.84 ? 250 GLY M N 1 ATOM 1962 C CA . GLY A 1 250 ? 35.990 105.631 69.568 1.00 7.66 ? 250 GLY M CA 1 ATOM 1963 C C . GLY A 1 250 ? 35.774 105.188 68.137 1.00 9.78 ? 250 GLY M C 1 ATOM 1964 O O . GLY A 1 250 ? 35.284 104.085 67.876 1.00 11.11 ? 250 GLY M O 1 ATOM 1965 N N . LYS A 1 251 ? 36.143 106.060 67.208 1.00 8.28 ? 251 LYS M N 1 ATOM 1966 C CA . LYS A 1 251 ? 36.000 105.790 65.786 1.00 8.52 ? 251 LYS M CA 1 ATOM 1967 C C . LYS A 1 251 ? 37.326 106.064 65.097 1.00 10.12 ? 251 LYS M C 1 ATOM 1968 O O . LYS A 1 251 ? 38.112 106.895 65.551 1.00 9.19 ? 251 LYS M O 1 ATOM 1969 C CB . LYS A 1 251 ? 34.922 106.689 65.179 1.00 9.28 ? 251 LYS M CB 1 ATOM 1970 C CG . LYS A 1 251 ? 33.511 106.376 65.642 1.00 14.50 ? 251 LYS M CG 1 ATOM 1971 C CD . LYS A 1 251 ? 32.502 107.277 64.955 1.00 15.93 ? 251 LYS M CD 1 ATOM 1972 C CE . LYS A 1 251 ? 31.090 107.005 65.455 1.00 23.24 ? 251 LYS M CE 1 ATOM 1973 N NZ . LYS A 1 251 ? 30.676 105.594 65.217 1.00 26.92 ? 251 LYS M NZ 1 ATOM 1974 N N . ILE A 1 252 ? 37.554 105.380 63.983 1.00 7.78 ? 252 ILE M N 1 ATOM 1975 C CA . ILE A 1 252 ? 38.792 105.543 63.236 1.00 7.93 ? 252 ILE M CA 1 ATOM 1976 C C . ILE A 1 252 ? 38.511 105.540 61.742 1.00 8.44 ? 252 ILE M C 1 ATOM 1977 O O . ILE A 1 252 ? 37.560 104.914 61.276 1.00 8.48 ? 252 ILE M O 1 ATOM 1978 C CB . ILE A 1 252 ? 39.795 104.415 63.595 1.00 8.11 ? 252 ILE M CB 1 ATOM 1979 C CG1 . ILE A 1 252 ? 41.173 104.703 62.998 1.00 8.39 ? 252 ILE M CG1 1 ATOM 1980 C CG2 . ILE A 1 252 ? 39.268 103.052 63.116 1.00 8.59 ? 252 ILE M CG2 1 ATOM 1981 C CD1 . ILE A 1 252 ? 42.290 103.874 63.631 1.00 6.11 ? 252 ILE M CD1 1 ATOM 1982 N N . GLY A 1 253 ? 39.313 106.293 60.999 1.00 7.14 ? 253 GLY M N 1 ATOM 1983 C CA . GLY A 1 253 ? 39.138 106.337 59.564 1.00 6.83 ? 253 GLY M CA 1 ATOM 1984 C C . GLY A 1 253 ? 40.335 106.955 58.886 1.00 6.66 ? 253 GLY M C 1 ATOM 1985 O O . GLY A 1 253 ? 41.219 107.495 59.547 1.00 7.15 ? 253 GLY M O 1 ATOM 1986 N N . PRO A 1 254 ? 40.417 106.835 57.556 1.00 6.42 ? 254 PRO M N 1 ATOM 1987 C CA . PRO A 1 254 ? 41.518 107.397 56.773 1.00 5.98 ? 254 PRO M CA 1 ATOM 1988 C C . PRO A 1 254 ? 41.162 108.831 56.408 1.00 8.23 ? 254 PRO M C 1 ATOM 1989 O O . PRO A 1 254 ? 40.031 109.276 56.621 1.00 7.91 ? 254 PRO M O 1 ATOM 1990 C CB . PRO A 1 254 ? 41.502 106.527 55.520 1.00 5.91 ? 254 PRO M CB 1 ATOM 1991 C CG . PRO A 1 254 ? 40.019 106.328 55.304 1.00 8.41 ? 254 PRO M CG 1 ATOM 1992 C CD . PRO A 1 254 ? 39.522 106.021 56.712 1.00 8.06 ? 254 PRO M CD 1 ATOM 1993 N N . THR A 1 255 ? 42.147 109.564 55.911 1.00 7.11 ? 255 THR M N 1 ATOM 1994 C CA . THR A 1 255 ? 41.905 110.920 55.456 1.00 8.17 ? 255 THR M CA 1 ATOM 1995 C C . THR A 1 255 ? 42.116 110.892 53.952 1.00 7.77 ? 255 THR M C 1 ATOM 1996 O O . THR A 1 255 ? 43.116 110.370 53.462 1.00 7.36 ? 255 THR M O 1 ATOM 1997 C CB . THR A 1 255 ? 42.864 111.941 56.092 1.00 8.31 ? 255 THR M CB 1 ATOM 1998 O OG1 . THR A 1 255 ? 42.556 112.082 57.486 1.00 18.63 ? 255 THR M OG1 1 ATOM 1999 C CG2 . THR A 1 255 ? 42.714 113.300 55.411 1.00 9.29 ? 255 THR M CG2 1 ATOM 2000 N N . MET A 1 256 ? 41.122 111.378 53.223 1.00 6.98 ? 256 MET M N 1 ATOM 2001 C CA . MET A 1 256 ? 41.196 111.431 51.778 1.00 8.40 ? 256 MET M CA 1 ATOM 2002 C C . MET A 1 256 ? 41.329 112.871 51.334 1.00 9.79 ? 256 MET M C 1 ATOM 2003 O O . MET A 1 256 ? 40.722 113.759 51.934 1.00 9.21 ? 256 MET M O 1 ATOM 2004 C CB . MET A 1 256 ? 39.892 110.910 51.168 1.00 10.32 ? 256 MET M CB 1 ATOM 2005 C CG . MET A 1 256 ? 39.701 109.413 51.186 1.00 10.36 ? 256 MET M CG 1 ATOM 2006 S SD . MET A 1 256 ? 40.712 108.617 49.949 1.00 11.37 ? 256 MET M SD 1 ATOM 2007 C CE . MET A 1 256 ? 40.006 109.284 48.435 1.00 10.70 ? 256 MET M CE 1 ATOM 2008 N N . ILE A 1 257 ? 42.199 113.124 50.361 1.00 9.40 ? 257 ILE M N 1 ATOM 2009 C CA . ILE A 1 257 ? 42.236 114.461 49.801 1.00 7.88 ? 257 ILE M CA 1 ATOM 2010 C C . ILE A 1 257 ? 41.195 114.321 48.689 1.00 8.32 ? 257 ILE M C 1 ATOM 2011 O O . ILE A 1 257 ? 41.198 113.341 47.927 1.00 8.66 ? 257 ILE M O 1 ATOM 2012 C CB . ILE A 1 257 ? 43.611 114.888 49.216 1.00 7.95 ? 257 ILE M CB 1 ATOM 2013 C CG1 . ILE A 1 257 ? 43.453 116.202 48.433 1.00 7.49 ? 257 ILE M CG1 1 ATOM 2014 C CG2 . ILE A 1 257 ? 44.211 113.800 48.337 1.00 6.60 ? 257 ILE M CG2 1 ATOM 2015 C CD1 . ILE A 1 257 ? 43.012 117.393 49.277 1.00 7.41 ? 257 ILE M CD1 1 ATOM 2016 N N . THR A 1 258 ? 40.209 115.202 48.703 1.00 7.30 ? 258 THR M N 1 ATOM 2017 C CA . THR A 1 258 ? 39.180 115.155 47.682 1.00 7.30 ? 258 THR M CA 1 ATOM 2018 C C . THR A 1 258 ? 39.226 116.411 46.841 1.00 8.36 ? 258 THR M C 1 ATOM 2019 O O . THR A 1 258 ? 39.702 117.457 47.273 1.00 7.55 ? 258 THR M O 1 ATOM 2020 C CB . THR A 1 258 ? 37.757 115.044 48.272 1.00 8.22 ? 258 THR M CB 1 ATOM 2021 O OG1 . THR A 1 258 ? 37.410 116.263 48.949 1.00 7.20 ? 258 THR M OG1 1 ATOM 2022 C CG2 . THR A 1 258 ? 37.671 113.869 49.246 1.00 7.95 ? 258 THR M CG2 1 ATOM 2023 N N . ARG A 1 259 ? 38.766 116.255 45.611 1.00 8.10 ? 259 ARG M N 1 ATOM 2024 C CA . ARG A 1 259 ? 38.647 117.334 44.648 1.00 6.56 ? 259 ARG M CA 1 ATOM 2025 C C . ARG A 1 259 ? 37.444 116.916 43.838 1.00 7.36 ? 259 ARG M C 1 ATOM 2026 O O . ARG A 1 259 ? 37.076 115.735 43.826 1.00 8.00 ? 259 ARG M O 1 ATOM 2027 C CB . ARG A 1 259 ? 39.827 117.364 43.671 1.00 9.42 ? 259 ARG M CB 1 ATOM 2028 C CG . ARG A 1 259 ? 41.171 117.739 44.241 1.00 6.70 ? 259 ARG M CG 1 ATOM 2029 C CD . ARG A 1 259 ? 42.203 117.755 43.119 1.00 11.36 ? 259 ARG M CD 1 ATOM 2030 N NE . ARG A 1 259 ? 43.567 117.840 43.633 1.00 11.88 ? 259 ARG M NE 1 ATOM 2031 C CZ . ARG A 1 259 ? 44.658 117.558 42.927 1.00 13.61 ? 259 ARG M CZ 1 ATOM 2032 N NH1 . ARG A 1 259 ? 44.560 117.177 41.660 1.00 15.54 ? 259 ARG M NH1 1 ATOM 2033 N NH2 . ARG A 1 259 ? 45.849 117.592 43.512 1.00 15.67 ? 259 ARG M NH2 1 ATOM 2034 N N . TRP A 1 260 ? 36.776 117.880 43.225 1.00 8.51 ? 260 TRP M N 1 ATOM 2035 C CA . TRP A 1 260 ? 35.702 117.506 42.327 1.00 7.43 ? 260 TRP M CA 1 ATOM 2036 C C . TRP A 1 260 ? 36.339 117.706 40.956 1.00 8.64 ? 260 TRP M C 1 ATOM 2037 O O . TRP A 1 260 ? 37.422 118.304 40.838 1.00 7.01 ? 260 TRP M O 1 ATOM 2038 C CB . TRP A 1 260 ? 34.459 118.384 42.475 1.00 7.09 ? 260 TRP M CB 1 ATOM 2039 C CG . TRP A 1 260 ? 33.288 117.847 41.683 1.00 9.04 ? 260 TRP M CG 1 ATOM 2040 C CD1 . TRP A 1 260 ? 32.518 118.531 40.786 1.00 8.65 ? 260 TRP M CD1 1 ATOM 2041 C CD2 . TRP A 1 260 ? 32.766 116.511 41.723 1.00 8.19 ? 260 TRP M CD2 1 ATOM 2042 N NE1 . TRP A 1 260 ? 31.547 117.703 40.264 1.00 9.03 ? 260 TRP M NE1 1 ATOM 2043 C CE2 . TRP A 1 260 ? 31.679 116.458 40.821 1.00 8.31 ? 260 TRP M CE2 1 ATOM 2044 C CE3 . TRP A 1 260 ? 33.113 115.353 42.434 1.00 9.27 ? 260 TRP M CE3 1 ATOM 2045 C CZ2 . TRP A 1 260 ? 30.930 115.292 40.613 1.00 8.83 ? 260 TRP M CZ2 1 ATOM 2046 C CZ3 . TRP A 1 260 ? 32.369 114.193 42.228 1.00 10.50 ? 260 TRP M CZ3 1 ATOM 2047 C CH2 . TRP A 1 260 ? 31.290 114.173 41.322 1.00 9.13 ? 260 TRP M CH2 1 ATOM 2048 N N . PHE A 1 261 ? 35.722 117.139 39.933 1.00 7.59 ? 261 PHE M N 1 ATOM 2049 C CA . PHE A 1 261 ? 36.226 117.281 38.580 1.00 7.96 ? 261 PHE M CA 1 ATOM 2050 C C . PHE A 1 261 ? 35.065 117.562 37.660 1.00 6.77 ? 261 PHE M C 1 ATOM 2051 O O . PHE A 1 261 ? 33.998 116.955 37.790 1.00 7.80 ? 261 PHE M O 1 ATOM 2052 C CB . PHE A 1 261 ? 36.951 116.008 38.133 1.00 8.24 ? 261 PHE M CB 1 ATOM 2053 C CG . PHE A 1 261 ? 38.166 115.688 38.955 1.00 7.15 ? 261 PHE M CG 1 ATOM 2054 C CD1 . PHE A 1 261 ? 39.357 116.373 38.752 1.00 8.72 ? 261 PHE M CD1 1 ATOM 2055 C CD2 . PHE A 1 261 ? 38.109 114.724 39.958 1.00 7.83 ? 261 PHE M CD2 1 ATOM 2056 C CE1 . PHE A 1 261 ? 40.483 116.099 39.530 1.00 9.47 ? 261 PHE M CE1 1 ATOM 2057 C CE2 . PHE A 1 261 ? 39.227 114.442 40.741 1.00 9.19 ? 261 PHE M CE2 1 ATOM 2058 C CZ . PHE A 1 261 ? 40.415 115.133 40.531 1.00 8.82 ? 261 PHE M CZ 1 ATOM 2059 N N . LEU A 1 262 ? 35.273 118.518 36.761 1.00 7.58 ? 262 LEU M N 1 ATOM 2060 C CA . LEU A 1 262 ? 34.276 118.907 35.774 1.00 8.86 ? 262 LEU M CA 1 ATOM 2061 C C . LEU A 1 262 ? 34.925 118.782 34.404 1.00 7.47 ? 262 LEU M C 1 ATOM 2062 O O . LEU A 1 262 ? 36.144 118.881 34.273 1.00 7.41 ? 262 LEU M O 1 ATOM 2063 C CB . LEU A 1 262 ? 33.843 120.362 35.991 1.00 8.59 ? 262 LEU M CB 1 ATOM 2064 C CG . LEU A 1 262 ? 33.134 120.704 37.301 1.00 10.48 ? 262 LEU M CG 1 ATOM 2065 C CD1 . LEU A 1 262 ? 32.910 122.208 37.363 1.00 11.34 ? 262 LEU M CD1 1 ATOM 2066 C CD2 . LEU A 1 262 ? 31.809 119.951 37.414 1.00 13.42 ? 262 LEU M CD2 1 ATOM 2067 N N . PRO A 1 263 ? 34.119 118.536 33.363 1.00 7.46 ? 263 PRO M N 1 ATOM 2068 C CA . PRO A 1 263 ? 34.687 118.411 32.019 1.00 8.41 ? 263 PRO M CA 1 ATOM 2069 C C . PRO A 1 263 ? 35.188 119.755 31.499 1.00 7.75 ? 263 PRO M C 1 ATOM 2070 O O . PRO A 1 263 ? 34.497 120.768 31.612 1.00 8.22 ? 263 PRO M O 1 ATOM 2071 C CB . PRO A 1 263 ? 33.494 117.933 31.186 1.00 9.73 ? 263 PRO M CB 1 ATOM 2072 C CG . PRO A 1 263 ? 32.601 117.261 32.186 1.00 13.57 ? 263 PRO M CG 1 ATOM 2073 C CD . PRO A 1 263 ? 32.690 118.179 33.370 1.00 10.18 ? 263 PRO M CD 1 ATOM 2074 N N . TYR A 1 264 ? 36.408 119.749 30.968 1.00 7.99 ? 264 TYR M N 1 ATOM 2075 C CA . TYR A 1 264 ? 37.037 120.922 30.373 1.00 9.00 ? 264 TYR M CA 1 ATOM 2076 C C . TYR A 1 264 ? 36.088 121.437 29.281 1.00 10.91 ? 264 TYR M C 1 ATOM 2077 O O . TYR A 1 264 ? 35.961 122.643 29.050 1.00 9.74 ? 264 TYR M O 1 ATOM 2078 C CB . TYR A 1 264 ? 38.384 120.499 29.788 1.00 8.64 ? 264 TYR M CB 1 ATOM 2079 C CG . TYR A 1 264 ? 39.096 121.543 28.968 1.00 10.03 ? 264 TYR M CG 1 ATOM 2080 C CD1 . TYR A 1 264 ? 39.667 122.662 29.569 1.00 11.22 ? 264 TYR M CD1 1 ATOM 2081 C CD2 . TYR A 1 264 ? 39.228 121.393 27.589 1.00 11.75 ? 264 TYR M CD2 1 ATOM 2082 C CE1 . TYR A 1 264 ? 40.358 123.608 28.812 1.00 11.16 ? 264 TYR M CE1 1 ATOM 2083 C CE2 . TYR A 1 264 ? 39.913 122.329 26.826 1.00 12.68 ? 264 TYR M CE2 1 ATOM 2084 C CZ . TYR A 1 264 ? 40.475 123.432 27.444 1.00 13.59 ? 264 TYR M CZ 1 ATOM 2085 O OH . TYR A 1 264 ? 41.149 124.364 26.691 1.00 15.06 ? 264 TYR M OH 1 ATOM 2086 N N . ASN A 1 265 ? 35.407 120.501 28.628 1.00 11.52 ? 265 ASN M N 1 ATOM 2087 C CA . ASN A 1 265 ? 34.424 120.822 27.606 1.00 10.91 ? 265 ASN M CA 1 ATOM 2088 C C . ASN A 1 265 ? 33.260 119.882 27.894 1.00 10.48 ? 265 ASN M C 1 ATOM 2089 O O . ASN A 1 265 ? 33.347 118.682 27.631 1.00 11.53 ? 265 ASN M O 1 ATOM 2090 C CB . ASN A 1 265 ? 34.985 120.581 26.208 1.00 11.16 ? 265 ASN M CB 1 ATOM 2091 C CG . ASN A 1 265 ? 34.010 120.975 25.126 1.00 10.77 ? 265 ASN M CG 1 ATOM 2092 O OD1 . ASN A 1 265 ? 32.800 120.873 25.306 1.00 11.88 ? 265 ASN M OD1 1 ATOM 2093 N ND2 . ASN A 1 265 ? 34.534 121.434 23.999 1.00 15.67 ? 265 ASN M ND2 1 ATOM 2094 N N . ASP A 1 266 ? 32.171 120.436 28.421 1.00 11.11 ? 266 ASP M N 1 ATOM 2095 C CA . ASP A 1 266 ? 31.015 119.630 28.798 1.00 13.20 ? 266 ASP M CA 1 ATOM 2096 C C . ASP A 1 266 ? 30.174 119.019 27.683 1.00 14.33 ? 266 ASP M C 1 ATOM 2097 O O . ASP A 1 266 ? 29.191 118.336 27.964 1.00 15.26 ? 266 ASP M O 1 ATOM 2098 C CB . ASP A 1 266 ? 30.134 120.371 29.818 1.00 17.50 ? 266 ASP M CB 1 ATOM 2099 C CG . ASP A 1 266 ? 29.543 121.663 29.276 1.00 21.57 ? 266 ASP M CG 1 ATOM 2100 O OD1 . ASP A 1 266 ? 29.518 121.860 28.046 1.00 22.23 ? 266 ASP M OD1 1 ATOM 2101 O OD2 . ASP A 1 266 ? 29.093 122.491 30.097 1.00 29.05 ? 266 ASP M OD2 1 ATOM 2102 N N . THR A 1 267 ? 30.539 119.280 26.430 1.00 13.53 ? 267 THR M N 1 ATOM 2103 C CA . THR A 1 267 ? 29.817 118.700 25.299 1.00 16.22 ? 267 THR M CA 1 ATOM 2104 C C . THR A 1 267 ? 30.733 117.782 24.492 1.00 15.76 ? 267 THR M C 1 ATOM 2105 O O . THR A 1 267 ? 30.347 117.275 23.440 1.00 16.97 ? 267 THR M O 1 ATOM 2106 C CB . THR A 1 267 ? 29.205 119.778 24.365 1.00 17.20 ? 267 THR M CB 1 ATOM 2107 O OG1 . THR A 1 267 ? 30.246 120.543 23.747 1.00 20.91 ? 267 THR M OG1 1 ATOM 2108 C CG2 . THR A 1 267 ? 28.285 120.704 25.150 1.00 19.55 ? 267 THR M CG2 1 ATOM 2109 N N . ASP A 1 268 ? 31.950 117.580 24.993 1.00 13.39 ? 268 ASP M N 1 ATOM 2110 C CA . ASP A 1 268 ? 32.944 116.724 24.349 1.00 11.94 ? 268 ASP M CA 1 ATOM 2111 C C . ASP A 1 268 ? 33.032 115.409 25.121 1.00 12.89 ? 268 ASP M C 1 ATOM 2112 O O . ASP A 1 268 ? 33.454 115.390 26.276 1.00 12.40 ? 268 ASP M O 1 ATOM 2113 C CB . ASP A 1 268 ? 34.310 117.428 24.337 1.00 14.52 ? 268 ASP M CB 1 ATOM 2114 C CG . ASP A 1 268 ? 35.456 116.512 23.911 1.00 18.19 ? 268 ASP M CG 1 ATOM 2115 O OD1 . ASP A 1 268 ? 35.238 115.567 23.125 1.00 21.47 ? 268 ASP M OD1 1 ATOM 2116 O OD2 . ASP A 1 268 ? 36.592 116.749 24.367 1.00 26.31 ? 268 ASP M OD2 1 ATOM 2117 N N . ARG A 1 269 ? 32.663 114.309 24.471 1.00 12.17 ? 269 ARG M N 1 ATOM 2118 C CA . ARG A 1 269 ? 32.688 113.004 25.127 1.00 10.20 ? 269 ARG M CA 1 ATOM 2119 C C . ARG A 1 269 ? 34.061 112.617 25.669 1.00 9.83 ? 269 ARG M C 1 ATOM 2120 O O . ARG A 1 269 ? 34.153 111.914 26.674 1.00 10.40 ? 269 ARG M O 1 ATOM 2121 C CB . ARG A 1 269 ? 32.161 111.913 24.187 1.00 13.06 ? 269 ARG M CB 1 ATOM 2122 C CG . ARG A 1 269 ? 33.009 111.676 22.947 1.00 15.52 ? 269 ARG M CG 1 ATOM 2123 C CD . ARG A 1 269 ? 32.364 110.626 22.058 1.00 19.23 ? 269 ARG M CD 1 ATOM 2124 N NE . ARG A 1 269 ? 33.179 110.315 20.885 1.00 19.93 ? 269 ARG M NE 1 ATOM 2125 C CZ . ARG A 1 269 ? 34.111 109.366 20.846 1.00 19.91 ? 269 ARG M CZ 1 ATOM 2126 N NH1 . ARG A 1 269 ? 34.360 108.626 21.917 1.00 20.63 ? 269 ARG M NH1 1 ATOM 2127 N NH2 . ARG A 1 269 ? 34.783 109.142 19.724 1.00 23.35 ? 269 ARG M NH2 1 ATOM 2128 N N . HIS A 1 270 ? 35.124 113.081 25.013 1.00 9.15 ? 270 HIS M N 1 ATOM 2129 C CA . HIS A 1 270 ? 36.481 112.765 25.451 1.00 8.80 ? 270 HIS M CA 1 ATOM 2130 C C . HIS A 1 270 ? 36.819 113.465 26.763 1.00 9.58 ? 270 HIS M C 1 ATOM 2131 O O . HIS A 1 270 ? 37.474 112.889 27.630 1.00 9.93 ? 270 HIS M O 1 ATOM 2132 C CB . HIS A 1 270 ? 37.494 113.137 24.371 1.00 11.18 ? 270 HIS M CB 1 ATOM 2133 C CG . HIS A 1 270 ? 37.283 112.403 23.080 1.00 13.24 ? 270 HIS M CG 1 ATOM 2134 N ND1 . HIS A 1 270 ? 37.539 111.060 22.947 1.00 15.53 ? 270 HIS M ND1 1 ATOM 2135 C CD2 . HIS A 1 270 ? 36.817 112.827 21.884 1.00 16.81 ? 270 HIS M CD2 1 ATOM 2136 C CE1 . HIS A 1 270 ? 37.240 110.680 21.713 1.00 16.47 ? 270 HIS M CE1 1 ATOM 2137 N NE2 . HIS A 1 270 ? 36.802 111.729 21.051 1.00 17.41 ? 270 HIS M NE2 1 ATOM 2138 N N . SER A 1 271 ? 36.371 114.708 26.900 1.00 8.10 ? 271 SER M N 1 ATOM 2139 C CA . SER A 1 271 ? 36.607 115.473 28.121 1.00 8.45 ? 271 SER M CA 1 ATOM 2140 C C . SER A 1 271 ? 35.740 114.890 29.234 1.00 7.96 ? 271 SER M C 1 ATOM 2141 O O . SER A 1 271 ? 36.176 114.769 30.372 1.00 8.98 ? 271 SER M O 1 ATOM 2142 C CB . SER A 1 271 ? 36.262 116.948 27.902 1.00 11.79 ? 271 SER M CB 1 ATOM 2143 O OG . SER A 1 271 ? 36.357 117.678 29.112 1.00 14.35 ? 271 SER M OG 1 ATOM 2144 N N . ILE A 1 272 ? 34.510 114.522 28.890 1.00 7.97 ? 272 ILE M N 1 ATOM 2145 C CA . ILE A 1 272 ? 33.589 113.930 29.854 1.00 9.21 ? 272 ILE M CA 1 ATOM 2146 C C . ILE A 1 272 ? 34.180 112.619 30.395 1.00 8.21 ? 272 ILE M C 1 ATOM 2147 O O . ILE A 1 272 ? 34.157 112.373 31.605 1.00 9.48 ? 272 ILE M O 1 ATOM 2148 C CB . ILE A 1 272 ? 32.206 113.682 29.204 1.00 9.77 ? 272 ILE M CB 1 ATOM 2149 C CG1 . ILE A 1 272 ? 31.544 115.026 28.889 1.00 11.01 ? 272 ILE M CG1 1 ATOM 2150 C CG2 . ILE A 1 272 ? 31.318 112.859 30.125 1.00 11.26 ? 272 ILE M CG2 1 ATOM 2151 C CD1 . ILE A 1 272 ? 30.297 114.920 28.021 1.00 13.86 ? 272 ILE M CD1 1 ATOM 2152 N N . ALA A 1 273 ? 34.735 111.801 29.505 1.00 7.96 ? 273 ALA M N 1 ATOM 2153 C CA . ALA A 1 273 ? 35.347 110.529 29.902 1.00 8.68 ? 273 ALA M CA 1 ATOM 2154 C C . ALA A 1 273 ? 36.571 110.761 30.785 1.00 8.58 ? 273 ALA M C 1 ATOM 2155 O O . ALA A 1 273 ? 36.782 110.038 31.758 1.00 9.76 ? 273 ALA M O 1 ATOM 2156 C CB . ALA A 1 273 ? 35.736 109.718 28.675 1.00 9.86 ? 273 ALA M CB 1 ATOM 2157 N N . ALA A 1 274 ? 37.381 111.758 30.433 1.00 7.98 ? 274 ALA M N 1 ATOM 2158 C CA . ALA A 1 274 ? 38.577 112.091 31.208 1.00 7.60 ? 274 ALA M CA 1 ATOM 2159 C C . ALA A 1 274 ? 38.178 112.505 32.621 1.00 8.34 ? 274 ALA M C 1 ATOM 2160 O O . ALA A 1 274 ? 38.871 112.202 33.593 1.00 9.06 ? 274 ALA M O 1 ATOM 2161 C CB . ALA A 1 274 ? 39.353 113.225 30.518 1.00 8.49 ? 274 ALA M CB 1 ATOM 2162 N N . THR A 1 275 ? 37.044 113.189 32.722 1.00 6.73 ? 275 THR M N 1 ATOM 2163 C CA . THR A 1 275 ? 36.525 113.653 34.004 1.00 8.11 ? 275 THR M CA 1 ATOM 2164 C C . THR A 1 275 ? 36.137 112.467 34.879 1.00 8.78 ? 275 THR M C 1 ATOM 2165 O O . THR A 1 275 ? 36.437 112.436 36.075 1.00 9.43 ? 275 THR M O 1 ATOM 2166 C CB . THR A 1 275 ? 35.316 114.567 33.783 1.00 8.35 ? 275 THR M CB 1 ATOM 2167 O OG1 . THR A 1 275 ? 35.725 115.678 32.975 1.00 7.82 ? 275 THR M OG1 1 ATOM 2168 C CG2 . THR A 1 275 ? 34.770 115.077 35.105 1.00 7.82 ? 275 THR M CG2 1 ATOM 2169 N N . GLU A 1 276 ? 35.487 111.476 34.277 1.00 9.13 ? 276 GLU M N 1 ATOM 2170 C CA . GLU A 1 276 ? 35.093 110.298 35.033 1.00 9.61 ? 276 GLU M CA 1 ATOM 2171 C C . GLU A 1 276 ? 36.303 109.451 35.396 1.00 9.42 ? 276 GLU M C 1 ATOM 2172 O O . GLU A 1 276 ? 36.335 108.846 36.471 1.00 11.29 ? 276 GLU M O 1 ATOM 2173 C CB . GLU A 1 276 ? 34.043 109.487 34.274 1.00 8.80 ? 276 GLU M CB 1 ATOM 2174 C CG . GLU A 1 276 ? 32.730 110.239 34.122 1.00 10.56 ? 276 GLU M CG 1 ATOM 2175 C CD . GLU A 1 276 ? 32.202 110.794 35.433 1.00 16.95 ? 276 GLU M CD 1 ATOM 2176 O OE1 . GLU A 1 276 ? 31.972 110.004 36.375 1.00 18.86 ? 276 GLU M OE1 1 ATOM 2177 O OE2 . GLU A 1 276 ? 32.030 112.027 35.528 1.00 15.77 ? 276 GLU M OE2 1 ATOM 2178 N N . ARG A 1 277 ? 37.305 109.419 34.517 1.00 8.84 ? 277 ARG M N 1 ATOM 2179 C CA . ARG A 1 277 ? 38.524 108.670 34.808 1.00 8.57 ? 277 ARG M CA 1 ATOM 2180 C C . ARG A 1 277 ? 39.228 109.319 35.991 1.00 10.07 ? 277 ARG M C 1 ATOM 2181 O O . ARG A 1 277 ? 39.752 108.626 36.860 1.00 9.46 ? 277 ARG M O 1 ATOM 2182 C CB . ARG A 1 277 ? 39.477 108.643 33.614 1.00 11.86 ? 277 ARG M CB 1 ATOM 2183 C CG . ARG A 1 277 ? 39.114 107.635 32.544 1.00 13.17 ? 277 ARG M CG 1 ATOM 2184 C CD . ARG A 1 277 ? 40.316 107.343 31.658 1.00 13.50 ? 277 ARG M CD 1 ATOM 2185 N NE . ARG A 1 277 ? 40.839 108.545 31.011 1.00 13.26 ? 277 ARG M NE 1 ATOM 2186 C CZ . ARG A 1 277 ? 40.314 109.098 29.919 1.00 14.41 ? 277 ARG M CZ 1 ATOM 2187 N NH1 . ARG A 1 277 ? 39.240 108.564 29.345 1.00 12.21 ? 277 ARG M NH1 1 ATOM 2188 N NH2 . ARG A 1 277 ? 40.871 110.178 29.390 1.00 13.85 ? 277 ARG M NH2 1 ATOM 2189 N N . MET A 1 278 ? 39.226 110.650 36.026 1.00 8.32 ? 278 MET M N 1 ATOM 2190 C CA . MET A 1 278 ? 39.864 111.372 37.126 1.00 8.87 ? 278 MET M CA 1 ATOM 2191 C C . MET A 1 278 ? 39.241 111.017 38.458 1.00 9.21 ? 278 MET M C 1 ATOM 2192 O O . MET A 1 278 ? 39.950 110.846 39.443 1.00 8.60 ? 278 MET M O 1 ATOM 2193 C CB . MET A 1 278 ? 39.812 112.888 36.924 1.00 9.79 ? 278 MET M CB 1 ATOM 2194 C CG . MET A 1 278 ? 40.941 113.433 36.077 1.00 12.24 ? 278 MET M CG 1 ATOM 2195 S SD . MET A 1 278 ? 42.592 112.859 36.592 1.00 12.03 ? 278 MET M SD 1 ATOM 2196 C CE . MET A 1 278 ? 42.690 113.432 38.254 1.00 13.88 ? 278 MET M CE 1 ATOM 2197 N N . LYS A 1 279 ? 37.917 110.877 38.488 1.00 7.93 ? 279 LYS M N 1 ATOM 2198 C CA . LYS A 1 279 ? 37.241 110.525 39.733 1.00 7.50 ? 279 LYS M CA 1 ATOM 2199 C C . LYS A 1 279 ? 37.716 109.153 40.204 1.00 9.97 ? 279 LYS M C 1 ATOM 2200 O O . LYS A 1 279 ? 37.988 108.947 41.386 1.00 10.23 ? 279 LYS M O 1 ATOM 2201 C CB . LYS A 1 279 ? 35.723 110.550 39.544 1.00 7.60 ? 279 LYS M CB 1 ATOM 2202 C CG . LYS A 1 279 ? 35.201 111.947 39.238 1.00 9.99 ? 279 LYS M CG 1 ATOM 2203 C CD . LYS A 1 279 ? 33.719 111.940 38.899 1.00 10.56 ? 279 LYS M CD 1 ATOM 2204 C CE . LYS A 1 279 ? 33.266 113.333 38.486 1.00 10.51 ? 279 LYS M CE 1 ATOM 2205 N NZ . LYS A 1 279 ? 31.867 113.342 37.985 1.00 10.06 ? 279 LYS M NZ 1 ATOM 2206 N N . GLU A 1 280 ? 37.882 108.234 39.260 1.00 8.84 ? 280 GLU M N 1 ATOM 2207 C CA . GLU A 1 280 ? 38.342 106.888 39.589 1.00 8.81 ? 280 GLU M CA 1 ATOM 2208 C C . GLU A 1 280 ? 39.816 106.834 39.982 1.00 8.01 ? 280 GLU M C 1 ATOM 2209 O O . GLU A 1 280 ? 40.182 106.153 40.936 1.00 8.29 ? 280 GLU M O 1 ATOM 2210 C CB . GLU A 1 280 ? 38.087 105.939 38.415 1.00 9.75 ? 280 GLU M CB 1 ATOM 2211 C CG . GLU A 1 280 ? 36.613 105.622 38.188 1.00 13.54 ? 280 GLU M CG 1 ATOM 2212 C CD . GLU A 1 280 ? 36.050 104.681 39.239 1.00 18.06 ? 280 GLU M CD 1 ATOM 2213 O OE1 . GLU A 1 280 ? 35.784 105.128 40.374 1.00 19.62 ? 280 GLU M OE1 1 ATOM 2214 O OE2 . GLU A 1 280 ? 35.874 103.485 38.928 1.00 17.73 ? 280 GLU M OE2 1 ATOM 2215 N N . PHE A 1 281 ? 40.662 107.551 39.250 1.00 6.84 ? 281 PHE M N 1 ATOM 2216 C CA . PHE A 1 281 ? 42.093 107.545 39.534 1.00 7.20 ? 281 PHE M CA 1 ATOM 2217 C C . PHE A 1 281 ? 42.498 108.357 40.749 1.00 8.59 ? 281 PHE M C 1 ATOM 2218 O O . PHE A 1 281 ? 43.499 108.049 41.400 1.00 10.81 ? 281 PHE M O 1 ATOM 2219 C CB . PHE A 1 281 ? 42.881 108.025 38.318 1.00 8.13 ? 281 PHE M CB 1 ATOM 2220 C CG . PHE A 1 281 ? 43.218 106.929 37.349 1.00 9.10 ? 281 PHE M CG 1 ATOM 2221 C CD1 . PHE A 1 281 ? 42.318 106.559 36.355 1.00 11.04 ? 281 PHE M CD1 1 ATOM 2222 C CD2 . PHE A 1 281 ? 44.442 106.271 37.429 1.00 11.35 ? 281 PHE M CD2 1 ATOM 2223 C CE1 . PHE A 1 281 ? 42.629 105.539 35.453 1.00 13.23 ? 281 PHE M CE1 1 ATOM 2224 C CE2 . PHE A 1 281 ? 44.763 105.247 36.530 1.00 10.63 ? 281 PHE M CE2 1 ATOM 2225 C CZ . PHE A 1 281 ? 43.855 104.887 35.540 1.00 12.65 ? 281 PHE M CZ 1 ATOM 2226 N N . PHE A 1 282 ? 41.716 109.385 41.054 1.00 6.87 ? 282 PHE M N 1 ATOM 2227 C CA . PHE A 1 282 ? 42.012 110.258 42.184 1.00 7.12 ? 282 PHE M CA 1 ATOM 2228 C C . PHE A 1 282 ? 41.326 109.795 43.466 1.00 7.85 ? 282 PHE M C 1 ATOM 2229 O O . PHE A 1 282 ? 41.964 109.689 44.513 1.00 9.84 ? 282 PHE M O 1 ATOM 2230 C CB . PHE A 1 282 ? 41.599 111.694 41.848 1.00 6.90 ? 282 PHE M CB 1 ATOM 2231 C CG . PHE A 1 282 ? 42.134 112.726 42.802 1.00 8.01 ? 282 PHE M CG 1 ATOM 2232 C CD1 . PHE A 1 282 ? 43.404 113.262 42.617 1.00 7.98 ? 282 PHE M CD1 1 ATOM 2233 C CD2 . PHE A 1 282 ? 41.379 113.146 43.892 1.00 8.47 ? 282 PHE M CD2 1 ATOM 2234 C CE1 . PHE A 1 282 ? 43.910 114.211 43.502 1.00 10.69 ? 282 PHE M CE1 1 ATOM 2235 C CE2 . PHE A 1 282 ? 41.877 114.097 44.787 1.00 8.93 ? 282 PHE M CE2 1 ATOM 2236 C CZ . PHE A 1 282 ? 43.143 114.624 44.595 1.00 9.75 ? 282 PHE M CZ 1 ATOM 2237 N N . LEU A 1 283 ? 40.025 109.535 43.384 1.00 7.55 ? 283 LEU M N 1 ATOM 2238 C CA . LEU A 1 283 ? 39.254 109.095 44.545 1.00 8.10 ? 283 LEU M CA 1 ATOM 2239 C C . LEU A 1 283 ? 39.128 107.575 44.620 1.00 9.39 ? 283 LEU M C 1 ATOM 2240 O O . LEU A 1 283 ? 39.371 106.975 45.672 1.00 8.56 ? 283 LEU M O 1 ATOM 2241 C CB . LEU A 1 283 ? 37.850 109.714 44.512 1.00 9.05 ? 283 LEU M CB 1 ATOM 2242 C CG . LEU A 1 283 ? 37.745 111.239 44.418 1.00 9.92 ? 283 LEU M CG 1 ATOM 2243 C CD1 . LEU A 1 283 ? 36.288 111.646 44.241 1.00 10.95 ? 283 LEU M CD1 1 ATOM 2244 C CD2 . LEU A 1 283 ? 38.327 111.884 45.675 1.00 9.16 ? 283 LEU M CD2 1 ATOM 2245 N N . GLY A 1 284 ? 38.755 106.962 43.496 1.00 7.09 ? 284 GLY M N 1 ATOM 2246 C CA . GLY A 1 284 ? 38.566 105.521 43.445 1.00 7.66 ? 284 GLY M CA 1 ATOM 2247 C C . GLY A 1 284 ? 39.774 104.676 43.793 1.00 7.28 ? 284 GLY M C 1 ATOM 2248 O O . GLY A 1 284 ? 39.626 103.562 44.290 1.00 8.92 ? 284 GLY M O 1 ATOM 2249 N N . TRP A 1 285 ? 40.965 105.195 43.506 1.00 6.30 ? 285 TRP M N 1 ATOM 2250 C CA . TRP A 1 285 ? 42.221 104.506 43.791 1.00 6.37 ? 285 TRP M CA 1 ATOM 2251 C C . TRP A 1 285 ? 42.227 104.005 45.238 1.00 8.77 ? 285 TRP M C 1 ATOM 2252 O O . TRP A 1 285 ? 42.723 102.918 45.539 1.00 7.82 ? 285 TRP M O 1 ATOM 2253 C CB . TRP A 1 285 ? 43.368 105.491 43.561 1.00 7.18 ? 285 TRP M CB 1 ATOM 2254 C CG . TRP A 1 285 ? 44.761 104.934 43.594 1.00 6.13 ? 285 TRP M CG 1 ATOM 2255 C CD1 . TRP A 1 285 ? 45.141 103.632 43.786 1.00 6.20 ? 285 TRP M CD1 1 ATOM 2256 C CD2 . TRP A 1 285 ? 45.965 105.682 43.433 1.00 7.45 ? 285 TRP M CD2 1 ATOM 2257 N NE1 . TRP A 1 285 ? 46.512 103.531 43.757 1.00 7.63 ? 285 TRP M NE1 1 ATOM 2258 C CE2 . TRP A 1 285 ? 47.045 104.782 43.545 1.00 7.45 ? 285 TRP M CE2 1 ATOM 2259 C CE3 . TRP A 1 285 ? 46.243 107.040 43.214 1.00 8.06 ? 285 TRP M CE3 1 ATOM 2260 C CZ2 . TRP A 1 285 ? 48.378 105.184 43.437 1.00 6.99 ? 285 TRP M CZ2 1 ATOM 2261 C CZ3 . TRP A 1 285 ? 47.564 107.443 43.108 1.00 8.19 ? 285 TRP M CZ3 1 ATOM 2262 C CH2 . TRP A 1 285 ? 48.616 106.517 43.224 1.00 7.38 ? 285 TRP M CH2 1 ATOM 2263 N N . PHE A 1 286 ? 41.650 104.802 46.129 1.00 7.68 ? 286 PHE M N 1 ATOM 2264 C CA . PHE A 1 286 ? 41.590 104.440 47.536 1.00 7.63 ? 286 PHE M CA 1 ATOM 2265 C C . PHE A 1 286 ? 40.199 104.052 47.996 1.00 6.63 ? 286 PHE M C 1 ATOM 2266 O O . PHE A 1 286 ? 40.040 103.105 48.762 1.00 7.70 ? 286 PHE M O 1 ATOM 2267 C CB . PHE A 1 286 ? 42.148 105.586 48.374 1.00 7.28 ? 286 PHE M CB 1 ATOM 2268 C CG . PHE A 1 286 ? 43.559 105.921 48.021 1.00 7.77 ? 286 PHE M CG 1 ATOM 2269 C CD1 . PHE A 1 286 ? 44.601 105.104 48.453 1.00 9.10 ? 286 PHE M CD1 1 ATOM 2270 C CD2 . PHE A 1 286 ? 43.844 106.985 47.170 1.00 7.90 ? 286 PHE M CD2 1 ATOM 2271 C CE1 . PHE A 1 286 ? 45.910 105.335 48.034 1.00 8.92 ? 286 PHE M CE1 1 ATOM 2272 C CE2 . PHE A 1 286 ? 45.148 107.224 46.745 1.00 8.05 ? 286 PHE M CE2 1 ATOM 2273 C CZ . PHE A 1 286 ? 46.181 106.399 47.175 1.00 7.54 ? 286 PHE M CZ 1 ATOM 2274 N N . MET A 1 287 ? 39.184 104.751 47.498 1.00 8.57 ? 287 MET M N 1 ATOM 2275 C CA . MET A 1 287 ? 37.816 104.455 47.895 1.00 8.73 ? 287 MET M CA 1 ATOM 2276 C C . MET A 1 287 ? 37.311 103.114 47.378 1.00 8.33 ? 287 MET M C 1 ATOM 2277 O O . MET A 1 287 ? 36.444 102.505 47.998 1.00 9.63 ? 287 MET M O 1 ATOM 2278 C CB . MET A 1 287 ? 36.880 105.591 47.495 1.00 7.92 ? 287 MET M CB 1 ATOM 2279 C CG . MET A 1 287 ? 37.121 106.871 48.286 1.00 7.85 ? 287 MET M CG 1 ATOM 2280 S SD . MET A 1 287 ? 37.139 106.590 50.072 1.00 10.05 ? 287 MET M SD 1 ATOM 2281 C CE . MET A 1 287 ? 35.488 105.958 50.333 1.00 9.48 ? 287 MET M CE 1 ATOM 2282 N N . GLY A 1 288 ? 37.846 102.664 46.245 1.00 8.41 ? 288 GLY M N 1 ATOM 2283 C CA . GLY A 1 288 ? 37.461 101.365 45.707 1.00 7.60 ? 288 GLY M CA 1 ATOM 2284 C C . GLY A 1 288 ? 37.899 100.312 46.715 1.00 8.27 ? 288 GLY M C 1 ATOM 2285 O O . GLY A 1 288 ? 37.095 99.484 47.143 1.00 11.16 ? 288 GLY M O 1 ATOM 2286 N N . PRO A 1 289 ? 39.189 100.293 47.088 1.00 6.99 ? 289 PRO M N 1 ATOM 2287 C CA . PRO A 1 289 ? 39.659 99.309 48.067 1.00 7.29 ? 289 PRO M CA 1 ATOM 2288 C C . PRO A 1 289 ? 38.932 99.443 49.411 1.00 8.47 ? 289 PRO M C 1 ATOM 2289 O O . PRO A 1 289 ? 38.537 98.446 50.015 1.00 9.32 ? 289 PRO M O 1 ATOM 2290 C CB . PRO A 1 289 ? 41.138 99.655 48.195 1.00 8.06 ? 289 PRO M CB 1 ATOM 2291 C CG . PRO A 1 289 ? 41.495 100.024 46.784 1.00 10.15 ? 289 PRO M CG 1 ATOM 2292 C CD . PRO A 1 289 ? 40.330 100.918 46.391 1.00 7.04 ? 289 PRO M CD 1 ATOM 2293 N N . LEU A 1 290 ? 38.720 100.678 49.856 1.00 8.99 ? 290 LEU M N 1 ATOM 2294 C CA . LEU A 1 290 ? 38.053 100.920 51.135 1.00 9.00 ? 290 LEU M CA 1 ATOM 2295 C C . LEU A 1 290 ? 36.588 100.494 51.193 1.00 9.73 ? 290 LEU M C 1 ATOM 2296 O O . LEU A 1 290 ? 36.098 100.137 52.260 1.00 10.70 ? 290 LEU M O 1 ATOM 2297 C CB . LEU A 1 290 ? 38.185 102.391 51.549 1.00 9.07 ? 290 LEU M CB 1 ATOM 2298 C CG . LEU A 1 290 ? 39.601 102.857 51.904 1.00 9.84 ? 290 LEU M CG 1 ATOM 2299 C CD1 . LEU A 1 290 ? 39.637 104.373 51.993 1.00 11.35 ? 290 LEU M CD1 1 ATOM 2300 C CD2 . LEU A 1 290 ? 40.056 102.219 53.215 1.00 10.58 ? 290 LEU M CD2 1 ATOM 2301 N N . THR A 1 291 ? 35.896 100.495 50.055 1.00 9.95 ? 291 THR M N 1 ATOM 2302 C CA . THR A 1 291 ? 34.482 100.108 50.048 1.00 9.40 ? 291 THR M CA 1 ATOM 2303 C C . THR A 1 291 ? 34.208 98.768 49.384 1.00 12.43 ? 291 THR M C 1 ATOM 2304 O O . THR A 1 291 ? 33.134 98.188 49.569 1.00 12.71 ? 291 THR M O 1 ATOM 2305 C CB . THR A 1 291 ? 33.603 101.152 49.324 1.00 11.17 ? 291 THR M CB 1 ATOM 2306 O OG1 . THR A 1 291 ? 34.029 101.274 47.962 1.00 10.80 ? 291 THR M OG1 1 ATOM 2307 C CG2 . THR A 1 291 ? 33.688 102.507 50.009 1.00 11.19 ? 291 THR M CG2 1 ATOM 2308 N N . ASN A 1 292 ? 35.187 98.250 48.652 1.00 11.71 ? 292 ASN M N 1 ATOM 2309 C CA . ASN A 1 292 ? 34.974 97.005 47.935 1.00 14.55 ? 292 ASN M CA 1 ATOM 2310 C C . ASN A 1 292 ? 36.144 96.023 47.953 1.00 13.01 ? 292 ASN M C 1 ATOM 2311 O O . ASN A 1 292 ? 36.009 94.888 47.492 1.00 12.76 ? 292 ASN M O 1 ATOM 2312 C CB . ASN A 1 292 ? 34.592 97.348 46.496 1.00 14.55 ? 292 ASN M CB 1 ATOM 2313 C CG . ASN A 1 292 ? 33.967 96.186 45.769 1.00 18.41 ? 292 ASN M CG 1 ATOM 2314 O OD1 . ASN A 1 292 ? 32.924 95.671 46.177 1.00 20.74 ? 292 ASN M OD1 1 ATOM 2315 N ND2 . ASN A 1 292 ? 34.617 95.773 44.690 1.00 16.86 ? 292 ASN M ND2 1 ATOM 2316 N N . GLY A 1 293 ? 37.284 96.456 48.484 1.00 11.53 ? 293 GLY M N 1 ATOM 2317 C CA . GLY A 1 293 ? 38.453 95.595 48.551 1.00 11.18 ? 293 GLY M CA 1 ATOM 2318 C C . GLY A 1 293 ? 39.174 95.397 47.231 1.00 11.07 ? 293 GLY M C 1 ATOM 2319 O O . GLY A 1 293 ? 40.013 94.504 47.109 1.00 12.30 ? 293 GLY M O 1 ATOM 2320 N N . THR A 1 294 ? 38.852 96.227 46.243 1.00 11.05 ? 294 THR M N 1 ATOM 2321 C CA . THR A 1 294 ? 39.472 96.140 44.924 1.00 9.67 ? 294 THR M CA 1 ATOM 2322 C C . THR A 1 294 ? 39.683 97.529 44.337 1.00 7.90 ? 294 THR M C 1 ATOM 2323 O O . THR A 1 294 ? 38.978 98.475 44.684 1.00 9.93 ? 294 THR M O 1 ATOM 2324 C CB . THR A 1 294 ? 38.571 95.377 43.915 1.00 12.18 ? 294 THR M CB 1 ATOM 2325 O OG1 . THR A 1 294 ? 37.363 96.117 43.700 1.00 13.50 ? 294 THR M OG1 1 ATOM 2326 C CG2 . THR A 1 294 ? 38.222 93.990 44.430 1.00 13.66 ? 294 THR M CG2 1 ATOM 2327 N N . TYR A 1 295 ? 40.654 97.640 43.440 1.00 8.71 ? 295 TYR M N 1 ATOM 2328 C CA . TYR A 1 295 ? 40.920 98.898 42.758 1.00 9.15 ? 295 TYR M CA 1 ATOM 2329 C C . TYR A 1 295 ? 39.883 99.046 41.644 1.00 8.47 ? 295 TYR M C 1 ATOM 2330 O O . TYR A 1 295 ? 39.315 98.050 41.181 1.00 9.93 ? 295 TYR M O 1 ATOM 2331 C CB . TYR A 1 295 ? 42.320 98.872 42.141 1.00 9.30 ? 295 TYR M CB 1 ATOM 2332 C CG . TYR A 1 295 ? 43.432 98.966 43.154 1.00 7.30 ? 295 TYR M CG 1 ATOM 2333 C CD1 . TYR A 1 295 ? 43.575 100.102 43.948 1.00 7.65 ? 295 TYR M CD1 1 ATOM 2334 C CD2 . TYR A 1 295 ? 44.346 97.926 43.316 1.00 7.73 ? 295 TYR M CD2 1 ATOM 2335 C CE1 . TYR A 1 295 ? 44.604 100.204 44.878 1.00 7.68 ? 295 TYR M CE1 1 ATOM 2336 C CE2 . TYR A 1 295 ? 45.379 98.017 44.239 1.00 8.40 ? 295 TYR M CE2 1 ATOM 2337 C CZ . TYR A 1 295 ? 45.500 99.160 45.019 1.00 6.06 ? 295 TYR M CZ 1 ATOM 2338 O OH . TYR A 1 295 ? 46.523 99.259 45.933 1.00 8.73 ? 295 TYR M OH 1 ATOM 2339 N N . PRO A 1 296 ? 39.596 100.290 41.220 1.00 10.65 ? 296 PRO M N 1 ATOM 2340 C CA . PRO A 1 296 ? 38.619 100.525 40.148 1.00 9.37 ? 296 PRO M CA 1 ATOM 2341 C C . PRO A 1 296 ? 39.037 99.757 38.898 1.00 8.08 ? 296 PRO M C 1 ATOM 2342 O O . PRO A 1 296 ? 40.227 99.608 38.633 1.00 8.60 ? 296 PRO M O 1 ATOM 2343 C CB . PRO A 1 296 ? 38.736 102.029 39.909 1.00 11.65 ? 296 PRO M CB 1 ATOM 2344 C CG . PRO A 1 296 ? 39.084 102.557 41.269 1.00 9.38 ? 296 PRO M CG 1 ATOM 2345 C CD . PRO A 1 296 ? 40.123 101.566 41.740 1.00 11.48 ? 296 PRO M CD 1 ATOM 2346 N N . GLN A 1 297 ? 38.063 99.280 38.127 1.00 9.36 ? 297 GLN M N 1 ATOM 2347 C CA . GLN A 1 297 ? 38.374 98.525 36.918 1.00 9.74 ? 297 GLN M CA 1 ATOM 2348 C C . GLN A 1 297 ? 39.229 99.308 35.927 1.00 9.18 ? 297 GLN M C 1 ATOM 2349 O O . GLN A 1 297 ? 40.140 98.748 35.318 1.00 10.18 ? 297 GLN M O 1 ATOM 2350 C CB . GLN A 1 297 ? 37.096 98.039 36.231 1.00 10.49 ? 297 GLN M CB 1 ATOM 2351 C CG . GLN A 1 297 ? 37.355 97.024 35.121 1.00 11.48 ? 297 GLN M CG 1 ATOM 2352 C CD . GLN A 1 297 ? 37.942 95.733 35.654 1.00 12.61 ? 297 GLN M CD 1 ATOM 2353 O OE1 . GLN A 1 297 ? 37.415 95.147 36.598 1.00 14.28 ? 297 GLN M OE1 1 ATOM 2354 N NE2 . GLN A 1 297 ? 39.048 95.294 35.067 1.00 14.92 ? 297 GLN M NE2 1 ATOM 2355 N N . ILE A 1 298 ? 38.957 100.601 35.775 1.00 10.11 ? 298 ILE M N 1 ATOM 2356 C CA . ILE A 1 298 ? 39.737 101.412 34.843 1.00 12.36 ? 298 ILE M CA 1 ATOM 2357 C C . ILE A 1 298 ? 41.214 101.437 35.241 1.00 11.34 ? 298 ILE M C 1 ATOM 2358 O O . ILE A 1 298 ? 42.092 101.472 34.379 1.00 11.47 ? 298 ILE M O 1 ATOM 2359 C CB . ILE A 1 298 ? 39.169 102.844 34.689 1.00 11.32 ? 298 ILE M CB 1 ATOM 2360 C CG1 . ILE A 1 298 ? 39.928 103.605 33.597 1.00 13.92 ? 298 ILE M CG1 1 ATOM 2361 C CG2 . ILE A 1 298 ? 39.227 103.601 36.011 1.00 9.13 ? 298 ILE M CG2 1 ATOM 2362 C CD1 . ILE A 1 298 ? 39.822 102.975 32.222 1.00 16.40 ? 298 ILE M CD1 1 ATOM 2363 N N . MET A 1 299 ? 41.490 101.377 36.542 1.00 10.43 ? 299 MET M N 1 ATOM 2364 C CA . MET A 1 299 ? 42.876 101.360 37.000 1.00 9.48 ? 299 MET M CA 1 ATOM 2365 C C . MET A 1 299 ? 43.487 99.987 36.738 1.00 8.65 ? 299 MET M C 1 ATOM 2366 O O . MET A 1 299 ? 44.637 99.880 36.321 1.00 9.82 ? 299 MET M O 1 ATOM 2367 C CB . MET A 1 299 ? 42.973 101.714 38.483 1.00 10.70 ? 299 MET M CB 1 ATOM 2368 C CG . MET A 1 299 ? 42.577 103.142 38.778 1.00 9.30 ? 299 MET M CG 1 ATOM 2369 S SD . MET A 1 299 ? 43.084 103.664 40.418 1.00 9.57 ? 299 MET M SD 1 ATOM 2370 C CE . MET A 1 299 ? 44.871 103.716 40.209 1.00 11.21 ? 299 MET M CE 1 ATOM 2371 N N . ILE A 1 300 ? 42.710 98.937 36.983 1.00 8.63 ? 300 ILE M N 1 ATOM 2372 C CA . ILE A 1 300 ? 43.185 97.576 36.747 1.00 9.86 ? 300 ILE M CA 1 ATOM 2373 C C . ILE A 1 300 ? 43.564 97.409 35.274 1.00 11.82 ? 300 ILE M C 1 ATOM 2374 O O . ILE A 1 300 ? 44.627 96.874 34.954 1.00 10.94 ? 300 ILE M O 1 ATOM 2375 C CB . ILE A 1 300 ? 42.110 96.535 37.129 1.00 10.26 ? 300 ILE M CB 1 ATOM 2376 C CG1 . ILE A 1 300 ? 41.858 96.578 38.638 1.00 11.31 ? 300 ILE M CG1 1 ATOM 2377 C CG2 . ILE A 1 300 ? 42.554 95.128 36.712 1.00 12.56 ? 300 ILE M CG2 1 ATOM 2378 C CD1 . ILE A 1 300 ? 40.694 95.716 39.093 1.00 11.49 ? 300 ILE M CD1 1 ATOM 2379 N N . ASP A 1 301 ? 42.712 97.922 34.391 1.00 13.54 ? 301 ASP M N 1 ATOM 2380 C CA . ASP A 1 301 ? 42.930 97.830 32.950 1.00 14.84 ? 301 ASP M CA 1 ATOM 2381 C C . ASP A 1 301 ? 44.104 98.670 32.450 1.00 13.70 ? 301 ASP M C 1 ATOM 2382 O O . ASP A 1 301 ? 44.926 98.197 31.664 1.00 15.59 ? 301 ASP M O 1 ATOM 2383 C CB . ASP A 1 301 ? 41.662 98.251 32.190 1.00 17.44 ? 301 ASP M CB 1 ATOM 2384 C CG . ASP A 1 301 ? 40.476 97.332 32.455 1.00 19.61 ? 301 ASP M CG 1 ATOM 2385 O OD1 . ASP A 1 301 ? 40.680 96.180 32.882 1.00 21.40 ? 301 ASP M OD1 1 ATOM 2386 O OD2 . ASP A 1 301 ? 39.329 97.769 32.224 1.00 25.04 ? 301 ASP M OD2 1 ATOM 2387 N N . THR A 1 302 ? 44.189 99.909 32.925 1.00 11.74 ? 302 THR M N 1 ATOM 2388 C CA . THR A 1 302 ? 45.235 100.832 32.496 1.00 11.30 ? 302 THR M CA 1 ATOM 2389 C C . THR A 1 302 ? 46.614 100.579 33.090 1.00 11.24 ? 302 THR M C 1 ATOM 2390 O O . THR A 1 302 ? 47.619 100.568 32.373 1.00 11.72 ? 302 THR M O 1 ATOM 2391 C CB . THR A 1 302 ? 44.843 102.290 32.820 1.00 13.13 ? 302 THR M CB 1 ATOM 2392 O OG1 . THR A 1 302 ? 43.574 102.586 32.229 1.00 14.36 ? 302 THR M OG1 1 ATOM 2393 C CG2 . THR A 1 302 ? 45.886 103.264 32.282 1.00 15.26 ? 302 THR M CG2 1 ATOM 2394 N N . VAL A 1 303 ? 46.656 100.402 34.405 1.00 10.39 ? 303 VAL M N 1 ATOM 2395 C CA . VAL A 1 303 ? 47.914 100.201 35.114 1.00 10.97 ? 303 VAL M CA 1 ATOM 2396 C C . VAL A 1 303 ? 48.484 98.793 34.957 1.00 10.33 ? 303 VAL M C 1 ATOM 2397 O O . VAL A 1 303 ? 49.699 98.595 35.039 1.00 12.26 ? 303 VAL M O 1 ATOM 2398 C CB . VAL A 1 303 ? 47.766 100.596 36.593 1.00 9.69 ? 303 VAL M CB 1 ATOM 2399 C CG1 . VAL A 1 303 ? 49.117 100.585 37.278 1.00 9.25 ? 303 VAL M CG1 1 ATOM 2400 C CG2 . VAL A 1 303 ? 47.149 101.999 36.685 1.00 10.19 ? 303 VAL M CG2 1 ATOM 2401 N N . GLY A 1 304 ? 47.604 97.827 34.706 1.00 12.01 ? 304 GLY M N 1 ATOM 2402 C CA . GLY A 1 304 ? 48.026 96.450 34.496 1.00 14.98 ? 304 GLY M CA 1 ATOM 2403 C C . GLY A 1 304 ? 48.987 95.844 35.504 1.00 12.29 ? 304 GLY M C 1 ATOM 2404 O O . GLY A 1 304 ? 48.713 95.817 36.703 1.00 13.00 ? 304 GLY M O 1 ATOM 2405 N N . GLU A 1 305 ? 50.128 95.374 35.002 1.00 12.84 ? 305 GLU M N 1 ATOM 2406 C CA . GLU A 1 305 ? 51.159 94.732 35.815 1.00 15.50 ? 305 GLU M CA 1 ATOM 2407 C C . GLU A 1 305 ? 51.738 95.623 36.914 1.00 15.13 ? 305 GLU M C 1 ATOM 2408 O O . GLU A 1 305 ? 52.273 95.122 37.903 1.00 14.76 ? 305 GLU M O 1 ATOM 2409 C CB . GLU A 1 305 ? 52.286 94.225 34.906 1.00 20.34 ? 305 GLU M CB 1 ATOM 2410 C CG . GLU A 1 305 ? 53.361 93.406 35.616 1.00 30.78 ? 305 GLU M CG 1 ATOM 2411 C CD . GLU A 1 305 ? 54.463 92.918 34.682 1.00 33.30 ? 305 GLU M CD 1 ATOM 2412 O OE1 . GLU A 1 305 ? 54.249 92.886 33.449 1.00 37.03 ? 305 GLU M OE1 1 ATOM 2413 O OE2 . GLU A 1 305 ? 55.549 92.560 35.188 1.00 36.85 ? 305 GLU M OE2 1 ATOM 2414 N N . ARG A 1 306 ? 51.639 96.936 36.737 1.00 12.56 ? 306 ARG M N 1 ATOM 2415 C CA . ARG A 1 306 ? 52.160 97.879 37.726 1.00 11.62 ? 306 ARG M CA 1 ATOM 2416 C C . ARG A 1 306 ? 51.220 98.081 38.916 1.00 11.26 ? 306 ARG M C 1 ATOM 2417 O O . ARG A 1 306 ? 51.591 98.712 39.905 1.00 12.23 ? 306 ARG M O 1 ATOM 2418 C CB . ARG A 1 306 ? 52.481 99.223 37.068 1.00 10.52 ? 306 ARG M CB 1 ATOM 2419 C CG . ARG A 1 306 ? 53.676 99.185 36.116 1.00 12.14 ? 306 ARG M CG 1 ATOM 2420 C CD . ARG A 1 306 ? 53.906 100.530 35.444 1.00 12.07 ? 306 ARG M CD 1 ATOM 2421 N NE . ARG A 1 306 ? 52.838 100.859 34.501 1.00 10.66 ? 306 ARG M NE 1 ATOM 2422 C CZ . ARG A 1 306 ? 52.032 101.912 34.610 1.00 13.14 ? 306 ARG M CZ 1 ATOM 2423 N NH1 . ARG A 1 306 ? 52.169 102.763 35.622 1.00 10.54 ? 306 ARG M NH1 1 ATOM 2424 N NH2 . ARG A 1 306 ? 51.068 102.099 33.722 1.00 13.11 ? 306 ARG M NH2 1 ATOM 2425 N N . LEU A 1 307 ? 50.007 97.542 38.826 1.00 9.48 ? 307 LEU M N 1 ATOM 2426 C CA . LEU A 1 307 ? 49.045 97.682 39.915 1.00 10.64 ? 307 LEU M CA 1 ATOM 2427 C C . LEU A 1 307 ? 49.055 96.428 40.777 1.00 12.95 ? 307 LEU M C 1 ATOM 2428 O O . LEU A 1 307 ? 48.730 95.337 40.302 1.00 11.86 ? 307 LEU M O 1 ATOM 2429 C CB . LEU A 1 307 ? 47.638 97.922 39.362 1.00 10.52 ? 307 LEU M CB 1 ATOM 2430 C CG . LEU A 1 307 ? 46.580 98.331 40.391 1.00 10.56 ? 307 LEU M CG 1 ATOM 2431 C CD1 . LEU A 1 307 ? 46.904 99.713 40.950 1.00 11.38 ? 307 LEU M CD1 1 ATOM 2432 C CD2 . LEU A 1 307 ? 45.209 98.336 39.730 1.00 11.36 ? 307 LEU M CD2 1 ATOM 2433 N N . PRO A 1 308 ? 49.447 96.561 42.054 1.00 10.87 ? 308 PRO M N 1 ATOM 2434 C CA . PRO A 1 308 ? 49.482 95.398 42.945 1.00 12.72 ? 308 PRO M CA 1 ATOM 2435 C C . PRO A 1 308 ? 48.100 94.793 43.147 1.00 12.48 ? 308 PRO M C 1 ATOM 2436 O O . PRO A 1 308 ? 47.082 95.464 42.983 1.00 11.73 ? 308 PRO M O 1 ATOM 2437 C CB . PRO A 1 308 ? 50.014 95.986 44.253 1.00 13.11 ? 308 PRO M CB 1 ATOM 2438 C CG . PRO A 1 308 ? 50.847 97.151 43.795 1.00 13.92 ? 308 PRO M CG 1 ATOM 2439 C CD . PRO A 1 308 ? 49.974 97.759 42.735 1.00 10.39 ? 308 PRO M CD 1 ATOM 2440 N N . SER A 1 309 ? 48.070 93.505 43.462 1.00 15.21 ? 309 SER M N 1 ATOM 2441 C CA . SER A 1 309 ? 46.811 92.822 43.707 1.00 15.25 ? 309 SER M CA 1 ATOM 2442 C C . SER A 1 309 ? 46.666 92.544 45.200 1.00 15.36 ? 309 SER M C 1 ATOM 2443 O O . SER A 1 309 ? 47.661 92.394 45.913 1.00 16.97 ? 309 SER M O 1 ATOM 2444 C CB . SER A 1 309 ? 46.759 91.503 42.931 1.00 21.50 ? 309 SER M CB 1 ATOM 2445 O OG . SER A 1 309 ? 47.823 90.652 43.317 1.00 26.60 ? 309 SER M OG 1 ATOM 2446 N N . PHE A 1 310 ? 45.427 92.559 45.676 1.00 14.09 ? 310 PHE M N 1 ATOM 2447 C CA . PHE A 1 310 ? 45.140 92.255 47.070 1.00 15.70 ? 310 PHE M CA 1 ATOM 2448 C C . PHE A 1 310 ? 44.820 90.769 47.133 1.00 16.90 ? 310 PHE M C 1 ATOM 2449 O O . PHE A 1 310 ? 44.132 90.247 46.257 1.00 16.94 ? 310 PHE M O 1 ATOM 2450 C CB . PHE A 1 310 ? 43.892 92.998 47.554 1.00 16.50 ? 310 PHE M CB 1 ATOM 2451 C CG . PHE A 1 310 ? 44.070 94.475 47.701 1.00 14.45 ? 310 PHE M CG 1 ATOM 2452 C CD1 . PHE A 1 310 ? 44.709 95.002 48.819 1.00 17.14 ? 310 PHE M CD1 1 ATOM 2453 C CD2 . PHE A 1 310 ? 43.567 95.346 46.738 1.00 14.90 ? 310 PHE M CD2 1 ATOM 2454 C CE1 . PHE A 1 310 ? 44.842 96.382 48.980 1.00 16.71 ? 310 PHE M CE1 1 ATOM 2455 C CE2 . PHE A 1 310 ? 43.695 96.729 46.893 1.00 15.30 ? 310 PHE M CE2 1 ATOM 2456 C CZ . PHE A 1 310 ? 44.334 97.243 48.014 1.00 15.31 ? 310 PHE M CZ 1 ATOM 2457 N N . SER A 1 311 ? 45.336 90.084 48.145 1.00 17.19 ? 311 SER M N 1 ATOM 2458 C CA . SER A 1 311 ? 45.022 88.673 48.325 1.00 18.11 ? 311 SER M CA 1 ATOM 2459 C C . SER A 1 311 ? 43.611 88.694 48.921 1.00 18.71 ? 311 SER M C 1 ATOM 2460 O O . SER A 1 311 ? 43.146 89.744 49.366 1.00 17.20 ? 311 SER M O 1 ATOM 2461 C CB . SER A 1 311 ? 45.991 88.035 49.322 1.00 19.25 ? 311 SER M CB 1 ATOM 2462 O OG . SER A 1 311 ? 45.821 88.583 50.619 1.00 17.94 ? 311 SER M OG 1 ATOM 2463 N N . PRO A 1 312 ? 42.898 87.556 48.906 1.00 18.85 ? 312 PRO M N 1 ATOM 2464 C CA . PRO A 1 312 ? 41.545 87.535 49.472 1.00 18.90 ? 312 PRO M CA 1 ATOM 2465 C C . PRO A 1 312 ? 41.516 88.060 50.912 1.00 18.24 ? 312 PRO M C 1 ATOM 2466 O O . PRO A 1 312 ? 40.618 88.816 51.287 1.00 17.67 ? 312 PRO M O 1 ATOM 2467 C CB . PRO A 1 312 ? 41.180 86.055 49.400 1.00 21.00 ? 312 PRO M CB 1 ATOM 2468 C CG . PRO A 1 312 ? 41.852 85.629 48.134 1.00 18.55 ? 312 PRO M CG 1 ATOM 2469 C CD . PRO A 1 312 ? 43.217 86.266 48.265 1.00 20.60 ? 312 PRO M CD 1 ATOM 2470 N N . GLU A 1 313 ? 42.528 87.690 51.693 1.00 17.70 ? 313 GLU M N 1 ATOM 2471 C CA . GLU A 1 313 ? 42.638 88.120 53.086 1.00 18.94 ? 313 GLU M CA 1 ATOM 2472 C C . GLU A 1 313 ? 42.843 89.631 53.178 1.00 16.58 ? 313 GLU M C 1 ATOM 2473 O O . GLU A 1 313 ? 42.219 90.301 54.002 1.00 16.17 ? 313 GLU M O 1 ATOM 2474 C CB . GLU A 1 313 ? 43.801 87.398 53.771 1.00 24.01 ? 313 GLU M CB 1 ATOM 2475 C CG . GLU A 1 313 ? 43.986 87.753 55.241 1.00 31.51 ? 313 GLU M CG 1 ATOM 2476 C CD . GLU A 1 313 ? 45.125 86.986 55.887 1.00 35.68 ? 313 GLU M CD 1 ATOM 2477 O OE1 . GLU A 1 313 ? 44.957 85.775 56.145 1.00 39.06 ? 313 GLU M OE1 1 ATOM 2478 O OE2 . GLU A 1 313 ? 46.189 87.594 56.137 1.00 39.02 ? 313 GLU M OE2 1 ATOM 2479 N N . GLU A 1 314 ? 43.725 90.156 52.333 1.00 15.35 ? 314 GLU M N 1 ATOM 2480 C CA . GLU A 1 314 ? 44.010 91.590 52.309 1.00 14.67 ? 314 GLU M CA 1 ATOM 2481 C C . GLU A 1 314 ? 42.792 92.380 51.845 1.00 13.39 ? 314 GLU M C 1 ATOM 2482 O O . GLU A 1 314 ? 42.474 93.428 52.404 1.00 12.24 ? 314 GLU M O 1 ATOM 2483 C CB . GLU A 1 314 ? 45.204 91.878 51.400 1.00 15.93 ? 314 GLU M CB 1 ATOM 2484 C CG . GLU A 1 314 ? 46.511 91.307 51.926 1.00 18.86 ? 314 GLU M CG 1 ATOM 2485 C CD . GLU A 1 314 ? 47.636 91.359 50.913 1.00 21.72 ? 314 GLU M CD 1 ATOM 2486 O OE1 . GLU A 1 314 ? 47.358 91.516 49.706 1.00 22.17 ? 314 GLU M OE1 1 ATOM 2487 O OE2 . GLU A 1 314 ? 48.807 91.230 51.328 1.00 24.77 ? 314 GLU M OE2 1 ATOM 2488 N N . SER A 1 315 ? 42.097 91.860 50.837 1.00 13.57 ? 315 SER M N 1 ATOM 2489 C CA . SER A 1 315 ? 40.905 92.519 50.314 1.00 13.38 ? 315 SER M CA 1 ATOM 2490 C C . SER A 1 315 ? 39.834 92.623 51.400 1.00 15.23 ? 315 SER M C 1 ATOM 2491 O O . SER A 1 315 ? 39.176 93.653 51.547 1.00 13.37 ? 315 SER M O 1 ATOM 2492 C CB . SER A 1 315 ? 40.363 91.747 49.109 1.00 16.67 ? 315 SER M CB 1 ATOM 2493 O OG . SER A 1 315 ? 39.164 92.329 48.635 1.00 23.33 ? 315 SER M OG 1 ATOM 2494 N N . ASN A 1 316 ? 39.673 91.548 52.164 1.00 14.69 ? 316 ASN M N 1 ATOM 2495 C CA . ASN A 1 316 ? 38.695 91.516 53.244 1.00 15.24 ? 316 ASN M CA 1 ATOM 2496 C C . ASN A 1 316 ? 39.094 92.493 54.352 1.00 15.11 ? 316 ASN M C 1 ATOM 2497 O O . ASN A 1 316 ? 38.239 93.139 54.964 1.00 14.31 ? 316 ASN M O 1 ATOM 2498 C CB . ASN A 1 316 ? 38.591 90.094 53.805 1.00 20.03 ? 316 ASN M CB 1 ATOM 2499 C CG . ASN A 1 316 ? 37.618 89.994 54.959 1.00 23.47 ? 316 ASN M CG 1 ATOM 2500 O OD1 . ASN A 1 316 ? 36.405 90.098 54.776 1.00 28.26 ? 316 ASN M OD1 1 ATOM 2501 N ND2 . ASN A 1 316 ? 38.148 89.801 56.160 1.00 25.65 ? 316 ASN M ND2 1 ATOM 2502 N N . LEU A 1 317 ? 40.398 92.598 54.591 1.00 12.69 ? 317 LEU M N 1 ATOM 2503 C CA . LEU A 1 317 ? 40.936 93.480 55.620 1.00 12.98 ? 317 LEU M CA 1 ATOM 2504 C C . LEU A 1 317 ? 40.731 94.951 55.263 1.00 11.09 ? 317 LEU M C 1 ATOM 2505 O O . LEU A 1 317 ? 40.345 95.760 56.108 1.00 11.32 ? 317 LEU M O 1 ATOM 2506 C CB . LEU A 1 317 ? 42.431 93.207 55.810 1.00 13.99 ? 317 LEU M CB 1 ATOM 2507 C CG . LEU A 1 317 ? 43.136 94.024 56.895 1.00 18.01 ? 317 LEU M CG 1 ATOM 2508 C CD1 . LEU A 1 317 ? 42.607 93.613 58.255 1.00 19.06 ? 317 LEU M CD1 1 ATOM 2509 C CD2 . LEU A 1 317 ? 44.640 93.815 56.825 1.00 20.99 ? 317 LEU M CD2 1 ATOM 2510 N N . VAL A 1 318 ? 40.994 95.289 54.005 1.00 11.03 ? 318 VAL M N 1 ATOM 2511 C CA . VAL A 1 318 ? 40.859 96.667 53.541 1.00 10.54 ? 318 VAL M CA 1 ATOM 2512 C C . VAL A 1 318 ? 39.410 97.103 53.338 1.00 9.65 ? 318 VAL M C 1 ATOM 2513 O O . VAL A 1 318 ? 39.051 98.244 53.638 1.00 8.54 ? 318 VAL M O 1 ATOM 2514 C CB . VAL A 1 318 ? 41.657 96.898 52.239 1.00 11.26 ? 318 VAL M CB 1 ATOM 2515 C CG1 . VAL A 1 318 ? 41.534 98.354 51.797 1.00 11.98 ? 318 VAL M CG1 1 ATOM 2516 C CG2 . VAL A 1 318 ? 43.123 96.545 52.454 1.00 12.81 ? 318 VAL M CG2 1 ATOM 2517 N N . LYS A 1 319 ? 38.574 96.198 52.837 1.00 8.54 ? 319 LYS M N 1 ATOM 2518 C CA . LYS A 1 319 ? 37.174 96.530 52.603 1.00 9.43 ? 319 LYS M CA 1 ATOM 2519 C C . LYS A 1 319 ? 36.450 96.879 53.897 1.00 9.62 ? 319 LYS M C 1 ATOM 2520 O O . LYS A 1 319 ? 36.460 96.105 54.857 1.00 10.93 ? 319 LYS M O 1 ATOM 2521 C CB . LYS A 1 319 ? 36.451 95.378 51.896 1.00 9.89 ? 319 LYS M CB 1 ATOM 2522 C CG . LYS A 1 319 ? 34.984 95.660 51.617 1.00 11.50 ? 319 LYS M CG 1 ATOM 2523 C CD . LYS A 1 319 ? 34.322 94.480 50.928 1.00 16.43 ? 319 LYS M CD 1 ATOM 2524 C CE . LYS A 1 319 ? 32.827 94.706 50.787 1.00 20.32 ? 319 LYS M CE 1 ATOM 2525 N NZ . LYS A 1 319 ? 32.153 93.516 50.199 1.00 25.28 ? 319 LYS M NZ 1 ATOM 2526 N N . GLY A 1 320 ? 35.836 98.059 53.910 1.00 10.11 ? 320 GLY M N 1 ATOM 2527 C CA . GLY A 1 320 ? 35.095 98.521 55.071 1.00 10.48 ? 320 GLY M CA 1 ATOM 2528 C C . GLY A 1 320 ? 35.959 98.930 56.249 1.00 8.33 ? 320 GLY M C 1 ATOM 2529 O O . GLY A 1 320 ? 35.452 99.058 57.360 1.00 9.95 ? 320 GLY M O 1 ATOM 2530 N N . SER A 1 321 ? 37.245 99.172 56.000 1.00 7.79 ? 321 SER M N 1 ATOM 2531 C CA . SER A 1 321 ? 38.186 99.549 57.056 1.00 9.14 ? 321 SER M CA 1 ATOM 2532 C C . SER A 1 321 ? 38.096 101.003 57.509 1.00 8.36 ? 321 SER M C 1 ATOM 2533 O O . SER A 1 321 ? 39.085 101.743 57.489 1.00 8.72 ? 321 SER M O 1 ATOM 2534 C CB . SER A 1 321 ? 39.624 99.206 56.649 1.00 11.00 ? 321 SER M CB 1 ATOM 2535 O OG . SER A 1 321 ? 40.011 99.918 55.485 1.00 10.18 ? 321 SER M OG 1 ATOM 2536 N N . TYR A 1 322 ? 36.902 101.403 57.929 1.00 9.11 ? 322 TYR M N 1 ATOM 2537 C CA . TYR A 1 322 ? 36.679 102.755 58.419 1.00 8.23 ? 322 TYR M CA 1 ATOM 2538 C C . TYR A 1 322 ? 35.337 102.869 59.111 1.00 9.41 ? 322 TYR M C 1 ATOM 2539 O O . TYR A 1 322 ? 34.387 102.163 58.767 1.00 9.90 ? 322 TYR M O 1 ATOM 2540 C CB . TYR A 1 322 ? 36.734 103.773 57.269 1.00 8.15 ? 322 TYR M CB 1 ATOM 2541 C CG . TYR A 1 322 ? 35.662 103.572 56.221 1.00 10.06 ? 322 TYR M CG 1 ATOM 2542 C CD1 . TYR A 1 322 ? 35.857 102.689 55.157 1.00 10.67 ? 322 TYR M CD1 1 ATOM 2543 C CD2 . TYR A 1 322 ? 34.444 104.253 56.299 1.00 9.11 ? 322 TYR M CD2 1 ATOM 2544 C CE1 . TYR A 1 322 ? 34.869 102.487 54.200 1.00 15.10 ? 322 TYR M CE1 1 ATOM 2545 C CE2 . TYR A 1 322 ? 33.443 104.056 55.342 1.00 13.07 ? 322 TYR M CE2 1 ATOM 2546 C CZ . TYR A 1 322 ? 33.667 103.171 54.297 1.00 15.31 ? 322 TYR M CZ 1 ATOM 2547 O OH . TYR A 1 322 ? 32.691 102.957 53.352 1.00 15.44 ? 322 TYR M OH 1 ATOM 2548 N N . ASP A 1 323 ? 35.288 103.732 60.122 1.00 8.34 ? 323 ASP M N 1 ATOM 2549 C CA . ASP A 1 323 ? 34.060 104.014 60.854 1.00 8.09 ? 323 ASP M CA 1 ATOM 2550 C C . ASP A 1 323 ? 33.526 105.320 60.286 1.00 9.95 ? 323 ASP M C 1 ATOM 2551 O O . ASP A 1 323 ? 32.333 105.617 60.370 1.00 10.16 ? 323 ASP M O 1 ATOM 2552 C CB . ASP A 1 323 ? 34.350 104.187 62.341 1.00 9.66 ? 323 ASP M CB 1 ATOM 2553 C CG . ASP A 1 323 ? 34.887 102.928 62.974 1.00 10.84 ? 323 ASP M CG 1 ATOM 2554 O OD1 . ASP A 1 323 ? 34.380 101.831 62.652 1.00 13.72 ? 323 ASP M OD1 1 ATOM 2555 O OD2 . ASP A 1 323 ? 35.811 103.035 63.798 1.00 10.55 ? 323 ASP M OD2 1 ATOM 2556 N N . PHE A 1 324 ? 34.442 106.114 59.738 1.00 8.82 ? 324 PHE M N 1 ATOM 2557 C CA . PHE A 1 324 ? 34.107 107.389 59.122 1.00 9.34 ? 324 PHE M CA 1 ATOM 2558 C C . PHE A 1 324 ? 35.226 107.768 58.167 1.00 7.48 ? 324 PHE M C 1 ATOM 2559 O O . PHE A 1 324 ? 36.277 107.122 58.128 1.00 7.41 ? 324 PHE M O 1 ATOM 2560 C CB . PHE A 1 324 ? 33.923 108.490 60.182 1.00 7.96 ? 324 PHE M CB 1 ATOM 2561 C CG . PHE A 1 324 ? 35.207 108.945 60.834 1.00 8.14 ? 324 PHE M CG 1 ATOM 2562 C CD1 . PHE A 1 324 ? 35.713 108.283 61.947 1.00 10.58 ? 324 PHE M CD1 1 ATOM 2563 C CD2 . PHE A 1 324 ? 35.897 110.049 60.342 1.00 10.03 ? 324 PHE M CD2 1 ATOM 2564 C CE1 . PHE A 1 324 ? 36.889 108.713 62.565 1.00 11.56 ? 324 PHE M CE1 1 ATOM 2565 C CE2 . PHE A 1 324 ? 37.073 110.487 60.952 1.00 12.66 ? 324 PHE M CE2 1 ATOM 2566 C CZ . PHE A 1 324 ? 37.567 109.817 62.066 1.00 11.94 ? 324 PHE M CZ 1 ATOM 2567 N N . LEU A 1 325 ? 34.986 108.800 57.372 1.00 6.03 ? 325 LEU M N 1 ATOM 2568 C CA . LEU A 1 325 ? 35.991 109.265 56.437 1.00 6.40 ? 325 LEU M CA 1 ATOM 2569 C C . LEU A 1 325 ? 36.338 110.696 56.768 1.00 7.79 ? 325 LEU M C 1 ATOM 2570 O O . LEU A 1 325 ? 35.450 111.506 57.033 1.00 8.60 ? 325 LEU M O 1 ATOM 2571 C CB . LEU A 1 325 ? 35.460 109.218 55.004 1.00 8.32 ? 325 LEU M CB 1 ATOM 2572 C CG . LEU A 1 325 ? 35.015 107.868 54.451 1.00 10.07 ? 325 LEU M CG 1 ATOM 2573 C CD1 . LEU A 1 325 ? 34.374 108.072 53.094 1.00 10.01 ? 325 LEU M CD1 1 ATOM 2574 C CD2 . LEU A 1 325 ? 36.205 106.928 54.356 1.00 10.90 ? 325 LEU M CD2 1 ATOM 2575 N N . GLY A 1 326 ? 37.637 110.976 56.824 1.00 7.05 ? 326 GLY M N 1 ATOM 2576 C CA . GLY A 1 326 ? 38.093 112.331 57.051 1.00 6.20 ? 326 GLY M CA 1 ATOM 2577 C C . GLY A 1 326 ? 38.305 112.847 55.639 1.00 7.71 ? 326 GLY M C 1 ATOM 2578 O O . GLY A 1 326 ? 39.151 112.327 54.908 1.00 7.81 ? 326 GLY M O 1 ATOM 2579 N N . LEU A 1 327 ? 37.479 113.795 55.213 1.00 6.18 ? 327 LEU M N 1 ATOM 2580 C CA . LEU A 1 327 ? 37.602 114.334 53.866 1.00 7.06 ? 327 LEU M CA 1 ATOM 2581 C C . LEU A 1 327 ? 38.172 115.740 53.835 1.00 7.34 ? 327 LEU M C 1 ATOM 2582 O O . LEU A 1 327 ? 37.615 116.667 54.424 1.00 7.80 ? 327 LEU M O 1 ATOM 2583 C CB . LEU A 1 327 ? 36.246 114.310 53.144 1.00 8.21 ? 327 LEU M CB 1 ATOM 2584 C CG . LEU A 1 327 ? 35.569 112.942 52.981 1.00 9.05 ? 327 LEU M CG 1 ATOM 2585 C CD1 . LEU A 1 327 ? 34.338 113.091 52.088 1.00 9.77 ? 327 LEU M CD1 1 ATOM 2586 C CD2 . LEU A 1 327 ? 36.541 111.925 52.378 1.00 9.17 ? 327 LEU M CD2 1 ATOM 2587 N N . ASN A 1 328 ? 39.332 115.874 53.205 1.00 6.48 ? 328 ASN M N 1 ATOM 2588 C CA . ASN A 1 328 ? 39.962 117.173 53.038 1.00 6.58 ? 328 ASN M CA 1 ATOM 2589 C C . ASN A 1 328 ? 39.494 117.680 51.681 1.00 7.26 ? 328 ASN M C 1 ATOM 2590 O O . ASN A 1 328 ? 39.452 116.915 50.715 1.00 8.30 ? 328 ASN M O 1 ATOM 2591 C CB . ASN A 1 328 ? 41.482 117.035 52.994 1.00 6.36 ? 328 ASN M CB 1 ATOM 2592 C CG . ASN A 1 328 ? 42.088 116.708 54.344 1.00 8.94 ? 328 ASN M CG 1 ATOM 2593 O OD1 . ASN A 1 328 ? 41.389 116.559 55.348 1.00 7.96 ? 328 ASN M OD1 1 ATOM 2594 N ND2 . ASN A 1 328 ? 43.414 116.612 54.376 1.00 7.53 ? 328 ASN M ND2 1 ATOM 2595 N N . TYR A 1 329 ? 39.135 118.955 51.604 1.00 6.78 ? 329 TYR M N 1 ATOM 2596 C CA . TYR A 1 329 ? 38.700 119.527 50.338 1.00 6.35 ? 329 TYR M CA 1 ATOM 2597 C C . TYR A 1 329 ? 39.220 120.946 50.178 1.00 6.80 ? 329 TYR M C 1 ATOM 2598 O O . TYR A 1 329 ? 39.085 121.769 51.081 1.00 7.73 ? 329 TYR M O 1 ATOM 2599 C CB . TYR A 1 329 ? 37.173 119.532 50.205 1.00 7.24 ? 329 TYR M CB 1 ATOM 2600 C CG . TYR A 1 329 ? 36.738 120.223 48.936 1.00 7.48 ? 329 TYR M CG 1 ATOM 2601 C CD1 . TYR A 1 329 ? 36.798 119.564 47.708 1.00 8.30 ? 329 TYR M CD1 1 ATOM 2602 C CD2 . TYR A 1 329 ? 36.388 121.574 48.946 1.00 6.29 ? 329 TYR M CD2 1 ATOM 2603 C CE1 . TYR A 1 329 ? 36.535 120.240 46.519 1.00 8.49 ? 329 TYR M CE1 1 ATOM 2604 C CE2 . TYR A 1 329 ? 36.129 122.257 47.769 1.00 6.33 ? 329 TYR M CE2 1 ATOM 2605 C CZ . TYR A 1 329 ? 36.207 121.585 46.559 1.00 7.20 ? 329 TYR M CZ 1 ATOM 2606 O OH . TYR A 1 329 ? 36.005 122.275 45.393 1.00 6.47 ? 329 TYR M OH 1 ATOM 2607 N N . TYR A 1 330 ? 39.772 121.230 49.003 1.00 7.71 ? 330 TYR M N 1 ATOM 2608 C CA . TYR A 1 330 ? 40.303 122.552 48.711 1.00 7.64 ? 330 TYR M CA 1 ATOM 2609 C C . TYR A 1 330 ? 39.813 123.129 47.399 1.00 7.09 ? 330 TYR M C 1 ATOM 2610 O O . TYR A 1 330 ? 39.375 124.279 47.354 1.00 7.47 ? 330 TYR M O 1 ATOM 2611 C CB . TYR A 1 330 ? 41.830 122.532 48.703 1.00 6.37 ? 330 TYR M CB 1 ATOM 2612 C CG . TYR A 1 330 ? 42.430 122.363 50.070 1.00 6.63 ? 330 TYR M CG 1 ATOM 2613 C CD1 . TYR A 1 330 ? 42.617 123.463 50.901 1.00 8.36 ? 330 TYR M CD1 1 ATOM 2614 C CD2 . TYR A 1 330 ? 42.820 121.107 50.532 1.00 10.00 ? 330 TYR M CD2 1 ATOM 2615 C CE1 . TYR A 1 330 ? 43.179 123.326 52.152 1.00 10.30 ? 330 TYR M CE1 1 ATOM 2616 C CE2 . TYR A 1 330 ? 43.388 120.955 51.790 1.00 10.88 ? 330 TYR M CE2 1 ATOM 2617 C CZ . TYR A 1 330 ? 43.562 122.075 52.594 1.00 10.70 ? 330 TYR M CZ 1 ATOM 2618 O OH . TYR A 1 330 ? 44.124 121.952 53.840 1.00 13.25 ? 330 TYR M OH 1 ATOM 2619 N N . PHE A 1 331 ? 39.880 122.338 46.331 1.00 6.00 ? 331 PHE M N 1 ATOM 2620 C CA . PHE A 1 331 ? 39.477 122.837 45.026 1.00 7.29 ? 331 PHE M CA 1 ATOM 2621 C C . PHE A 1 331 ? 39.010 121.783 44.027 1.00 7.16 ? 331 PHE M C 1 ATOM 2622 O O . PHE A 1 331 ? 39.043 120.574 44.293 1.00 7.64 ? 331 PHE M O 1 ATOM 2623 C CB . PHE A 1 331 ? 40.601 123.696 44.415 1.00 7.61 ? 331 PHE M CB 1 ATOM 2624 C CG . PHE A 1 331 ? 41.933 123.002 44.334 1.00 8.52 ? 331 PHE M CG 1 ATOM 2625 C CD1 . PHE A 1 331 ? 42.179 122.045 43.354 1.00 10.23 ? 331 PHE M CD1 1 ATOM 2626 C CD2 . PHE A 1 331 ? 42.947 123.317 45.232 1.00 12.82 ? 331 PHE M CD2 1 ATOM 2627 C CE1 . PHE A 1 331 ? 43.418 121.417 43.259 1.00 12.24 ? 331 PHE M CE1 1 ATOM 2628 C CE2 . PHE A 1 331 ? 44.191 122.696 45.146 1.00 12.22 ? 331 PHE M CE2 1 ATOM 2629 C CZ . PHE A 1 331 ? 44.425 121.741 44.160 1.00 14.24 ? 331 PHE M CZ 1 ATOM 2630 N N . THR A 1 332 ? 38.577 122.276 42.873 1.00 6.72 ? 332 THR M N 1 ATOM 2631 C CA . THR A 1 332 ? 38.057 121.453 41.790 1.00 6.71 ? 332 THR M CA 1 ATOM 2632 C C . THR A 1 332 ? 38.789 121.787 40.492 1.00 9.44 ? 332 THR M C 1 ATOM 2633 O O . THR A 1 332 ? 39.206 122.925 40.279 1.00 8.46 ? 332 THR M O 1 ATOM 2634 C CB . THR A 1 332 ? 36.539 121.712 41.645 1.00 7.85 ? 332 THR M CB 1 ATOM 2635 O OG1 . THR A 1 332 ? 35.870 121.184 42.798 1.00 7.63 ? 332 THR M OG1 1 ATOM 2636 C CG2 . THR A 1 332 ? 35.963 121.073 40.379 1.00 8.63 ? 332 THR M CG2 1 ATOM 2637 N N . GLN A 1 333 ? 38.961 120.791 39.628 1.00 7.40 ? 333 GLN M N 1 ATOM 2638 C CA . GLN A 1 333 ? 39.651 121.024 38.365 1.00 6.99 ? 333 GLN M CA 1 ATOM 2639 C C . GLN A 1 333 ? 38.856 120.539 37.173 1.00 8.91 ? 333 GLN M C 1 ATOM 2640 O O . GLN A 1 333 ? 38.009 119.653 37.295 1.00 7.94 ? 333 GLN M O 1 ATOM 2641 C CB . GLN A 1 333 ? 41.000 120.304 38.354 1.00 8.74 ? 333 GLN M CB 1 ATOM 2642 C CG . GLN A 1 333 ? 42.007 120.833 39.355 1.00 10.93 ? 333 GLN M CG 1 ATOM 2643 C CD . GLN A 1 333 ? 43.085 119.814 39.662 1.00 11.72 ? 333 GLN M CD 1 ATOM 2644 O OE1 . GLN A 1 333 ? 42.788 118.661 39.972 1.00 14.97 ? 333 GLN M OE1 1 ATOM 2645 N NE2 . GLN A 1 333 ? 44.341 120.228 39.564 1.00 15.33 ? 333 GLN M NE2 1 ATOM 2646 N N . TYR A 1 334 ? 39.125 121.152 36.026 1.00 8.10 ? 334 TYR M N 1 ATOM 2647 C CA . TYR A 1 334 ? 38.507 120.750 34.774 1.00 7.93 ? 334 TYR M CA 1 ATOM 2648 C C . TYR A 1 334 ? 39.429 119.664 34.238 1.00 8.40 ? 334 TYR M C 1 ATOM 2649 O O . TYR A 1 334 ? 40.651 119.749 34.386 1.00 7.81 ? 334 TYR M O 1 ATOM 2650 C CB . TYR A 1 334 ? 38.479 121.903 33.774 1.00 7.85 ? 334 TYR M CB 1 ATOM 2651 C CG . TYR A 1 334 ? 37.444 122.948 34.069 1.00 7.32 ? 334 TYR M CG 1 ATOM 2652 C CD1 . TYR A 1 334 ? 36.086 122.644 34.017 1.00 7.24 ? 334 TYR M CD1 1 ATOM 2653 C CD2 . TYR A 1 334 ? 37.817 124.249 34.401 1.00 6.41 ? 334 TYR M CD2 1 ATOM 2654 C CE1 . TYR A 1 334 ? 35.126 123.611 34.288 1.00 8.03 ? 334 TYR M CE1 1 ATOM 2655 C CE2 . TYR A 1 334 ? 36.869 125.216 34.671 1.00 6.73 ? 334 TYR M CE2 1 ATOM 2656 C CZ . TYR A 1 334 ? 35.529 124.895 34.616 1.00 9.70 ? 334 TYR M CZ 1 ATOM 2657 O OH . TYR A 1 334 ? 34.589 125.858 34.894 1.00 10.56 ? 334 TYR M OH 1 ATOM 2658 N N . ALA A 1 335 ? 38.847 118.653 33.605 1.00 6.93 ? 335 ALA M N 1 ATOM 2659 C CA . ALA A 1 335 ? 39.629 117.556 33.056 1.00 6.92 ? 335 ALA M CA 1 ATOM 2660 C C . ALA A 1 335 ? 39.427 117.414 31.557 1.00 7.66 ? 335 ALA M C 1 ATOM 2661 O O . ALA A 1 335 ? 38.313 117.539 31.057 1.00 9.19 ? 335 ALA M O 1 ATOM 2662 C CB . ALA A 1 335 ? 39.257 116.246 33.749 1.00 6.39 ? 335 ALA M CB 1 ATOM 2663 N N . GLN A 1 336 ? 40.526 117.173 30.853 1.00 8.22 ? 336 GLN M N 1 ATOM 2664 C CA . GLN A 1 336 ? 40.502 116.966 29.410 1.00 9.18 ? 336 GLN M CA 1 ATOM 2665 C C . GLN A 1 336 ? 41.407 115.779 29.137 1.00 8.23 ? 336 GLN M C 1 ATOM 2666 O O . GLN A 1 336 ? 42.247 115.432 29.965 1.00 9.34 ? 336 GLN M O 1 ATOM 2667 C CB . GLN A 1 336 ? 41.008 118.201 28.665 1.00 11.46 ? 336 GLN M CB 1 ATOM 2668 C CG . GLN A 1 336 ? 42.448 118.568 28.956 1.00 12.19 ? 336 GLN M CG 1 ATOM 2669 C CD . GLN A 1 336 ? 42.833 119.888 28.325 1.00 15.94 ? 336 GLN M CD 1 ATOM 2670 O OE1 . GLN A 1 336 ? 42.786 120.940 28.972 1.00 14.29 ? 336 GLN M OE1 1 ATOM 2671 N NE2 . GLN A 1 336 ? 43.210 119.845 27.055 1.00 13.28 ? 336 GLN M NE2 1 ATOM 2672 N N . PRO A 1 337 ? 41.231 115.114 27.989 1.00 8.53 ? 337 PRO M N 1 ATOM 2673 C CA . PRO A 1 337 ? 42.092 113.963 27.707 1.00 10.24 ? 337 PRO M CA 1 ATOM 2674 C C . PRO A 1 337 ? 43.569 114.318 27.538 1.00 10.69 ? 337 PRO M C 1 ATOM 2675 O O . PRO A 1 337 ? 43.920 115.435 27.156 1.00 11.33 ? 337 PRO M O 1 ATOM 2676 C CB . PRO A 1 337 ? 41.480 113.381 26.430 1.00 12.04 ? 337 PRO M CB 1 ATOM 2677 C CG . PRO A 1 337 ? 40.859 114.565 25.767 1.00 11.23 ? 337 PRO M CG 1 ATOM 2678 C CD . PRO A 1 337 ? 40.242 115.318 26.915 1.00 10.86 ? 337 PRO M CD 1 ATOM 2679 N N . SER A 1 338 ? 44.423 113.359 27.871 1.00 12.12 ? 338 SER M N 1 ATOM 2680 C CA . SER A 1 338 ? 45.867 113.521 27.762 1.00 15.08 ? 338 SER M CA 1 ATOM 2681 C C . SER A 1 338 ? 46.463 112.142 27.506 1.00 14.76 ? 338 SER M C 1 ATOM 2682 O O . SER A 1 338 ? 45.984 111.143 28.043 1.00 12.52 ? 338 SER M O 1 ATOM 2683 C CB . SER A 1 338 ? 46.431 114.101 29.061 1.00 17.10 ? 338 SER M CB 1 ATOM 2684 O OG . SER A 1 338 ? 47.828 114.312 28.967 1.00 24.71 ? 338 SER M OG 1 ATOM 2685 N N . PRO A 1 339 ? 47.505 112.065 26.665 1.00 16.18 ? 339 PRO M N 1 ATOM 2686 C CA . PRO A 1 339 ? 48.141 110.780 26.361 1.00 16.68 ? 339 PRO M CA 1 ATOM 2687 C C . PRO A 1 339 ? 48.803 110.162 27.586 1.00 13.09 ? 339 PRO M C 1 ATOM 2688 O O . PRO A 1 339 ? 49.179 110.865 28.524 1.00 15.39 ? 339 PRO M O 1 ATOM 2689 C CB . PRO A 1 339 ? 49.199 111.160 25.321 1.00 18.58 ? 339 PRO M CB 1 ATOM 2690 C CG . PRO A 1 339 ? 48.637 112.396 24.683 1.00 21.40 ? 339 PRO M CG 1 ATOM 2691 C CD . PRO A 1 339 ? 48.113 113.147 25.872 1.00 19.56 ? 339 PRO M CD 1 ATOM 2692 N N . ASN A 1 340 ? 48.930 108.840 27.573 1.00 14.34 ? 340 ASN M N 1 ATOM 2693 C CA . ASN A 1 340 ? 49.574 108.117 28.662 1.00 13.99 ? 340 ASN M CA 1 ATOM 2694 C C . ASN A 1 340 ? 50.749 107.330 28.078 1.00 16.66 ? 340 ASN M C 1 ATOM 2695 O O . ASN A 1 340 ? 50.603 106.161 27.724 1.00 18.01 ? 340 ASN M O 1 ATOM 2696 C CB . ASN A 1 340 ? 48.587 107.161 29.337 1.00 13.72 ? 340 ASN M CB 1 ATOM 2697 C CG . ASN A 1 340 ? 49.207 106.433 30.511 1.00 12.71 ? 340 ASN M CG 1 ATOM 2698 O OD1 . ASN A 1 340 ? 50.167 106.919 31.105 1.00 13.49 ? 340 ASN M OD1 1 ATOM 2699 N ND2 . ASN A 1 340 ? 48.673 105.263 30.845 1.00 13.59 ? 340 ASN M ND2 1 ATOM 2700 N N . PRO A 1 341 ? 51.927 107.973 27.957 1.00 17.77 ? 341 PRO M N 1 ATOM 2701 C CA . PRO A 1 341 ? 53.141 107.354 27.410 1.00 17.95 ? 341 PRO M CA 1 ATOM 2702 C C . PRO A 1 341 ? 53.866 106.447 28.407 1.00 18.39 ? 341 PRO M C 1 ATOM 2703 O O . PRO A 1 341 ? 54.926 106.797 28.925 1.00 16.93 ? 341 PRO M O 1 ATOM 2704 C CB . PRO A 1 341 ? 53.983 108.568 27.029 1.00 19.92 ? 341 PRO M CB 1 ATOM 2705 C CG . PRO A 1 341 ? 53.667 109.531 28.126 1.00 22.95 ? 341 PRO M CG 1 ATOM 2706 C CD . PRO A 1 341 ? 52.165 109.393 28.285 1.00 21.50 ? 341 PRO M CD 1 ATOM 2707 N N . VAL A 1 342 ? 53.313 105.255 28.615 1.00 16.83 ? 342 VAL M N 1 ATOM 2708 C CA . VAL A 1 342 ? 53.866 104.282 29.556 1.00 18.73 ? 342 VAL M CA 1 ATOM 2709 C C . VAL A 1 342 ? 55.310 103.856 29.262 1.00 21.17 ? 342 VAL M C 1 ATOM 2710 O O . VAL A 1 342 ? 56.056 103.505 30.176 1.00 20.57 ? 342 VAL M O 1 ATOM 2711 C CB . VAL A 1 342 ? 52.957 103.028 29.653 1.00 18.54 ? 342 VAL M CB 1 ATOM 2712 C CG1 . VAL A 1 342 ? 53.467 102.078 30.729 1.00 20.65 ? 342 VAL M CG1 1 ATOM 2713 C CG2 . VAL A 1 342 ? 51.520 103.439 29.967 1.00 17.11 ? 342 VAL M CG2 1 ATOM 2714 N N . ASN A 1 343 ? 55.709 103.920 27.994 1.00 22.26 ? 343 ASN M N 1 ATOM 2715 C CA . ASN A 1 343 ? 57.059 103.531 27.592 1.00 25.77 ? 343 ASN M CA 1 ATOM 2716 C C . ASN A 1 343 ? 58.119 104.612 27.782 1.00 24.66 ? 343 ASN M C 1 ATOM 2717 O O . ASN A 1 343 ? 59.316 104.315 27.781 1.00 26.05 ? 343 ASN M O 1 ATOM 2718 C CB . ASN A 1 343 ? 57.064 103.060 26.136 1.00 28.62 ? 343 ASN M CB 1 ATOM 2719 C CG . ASN A 1 343 ? 56.210 101.831 25.922 1.00 29.39 ? 343 ASN M CG 1 ATOM 2720 O OD1 . ASN A 1 343 ? 56.132 100.955 26.786 1.00 32.24 ? 343 ASN M OD1 1 ATOM 2721 N ND2 . ASN A 1 343 ? 55.567 101.753 24.762 1.00 32.82 ? 343 ASN M ND2 1 ATOM 2722 N N . SER A 1 344 ? 57.685 105.861 27.935 1.00 22.34 ? 344 SER M N 1 ATOM 2723 C CA . SER A 1 344 ? 58.612 106.976 28.126 1.00 21.14 ? 344 SER M CA 1 ATOM 2724 C C . SER A 1 344 ? 59.343 106.854 29.458 1.00 22.32 ? 344 SER M C 1 ATOM 2725 O O . SER A 1 344 ? 58.770 106.405 30.450 1.00 17.27 ? 344 SER M O 1 ATOM 2726 C CB . SER A 1 344 ? 57.871 108.313 28.066 1.00 23.60 ? 344 SER M CB 1 ATOM 2727 O OG . SER A 1 344 ? 57.328 108.542 26.775 1.00 31.81 ? 344 SER M OG 1 ATOM 2728 N N . THR A 1 345 ? 60.617 107.234 29.468 1.00 20.15 ? 345 THR M N 1 ATOM 2729 C CA . THR A 1 345 ? 61.416 107.166 30.687 1.00 21.88 ? 345 THR M CA 1 ATOM 2730 C C . THR A 1 345 ? 60.897 108.143 31.741 1.00 20.45 ? 345 THR M C 1 ATOM 2731 O O . THR A 1 345 ? 61.166 107.979 32.929 1.00 19.21 ? 345 THR M O 1 ATOM 2732 C CB . THR A 1 345 ? 62.905 107.466 30.414 1.00 21.52 ? 345 THR M CB 1 ATOM 2733 O OG1 . THR A 1 345 ? 63.036 108.768 29.832 1.00 26.12 ? 345 THR M OG1 1 ATOM 2734 C CG2 . THR A 1 345 ? 63.497 106.428 29.474 1.00 25.84 ? 345 THR M CG2 1 ATOM 2735 N N . ASN A 1 346 ? 60.161 109.163 31.301 1.00 18.02 ? 346 ASN M N 1 ATOM 2736 C CA . ASN A 1 346 ? 59.612 110.152 32.223 1.00 20.72 ? 346 ASN M CA 1 ATOM 2737 C C . ASN A 1 346 ? 58.165 109.862 32.620 1.00 16.08 ? 346 ASN M C 1 ATOM 2738 O O . ASN A 1 346 ? 57.490 110.718 33.190 1.00 15.34 ? 346 ASN M O 1 ATOM 2739 C CB . ASN A 1 346 ? 59.735 111.572 31.644 1.00 29.00 ? 346 ASN M CB 1 ATOM 2740 C CG . ASN A 1 346 ? 58.996 111.745 30.324 1.00 36.33 ? 346 ASN M CG 1 ATOM 2741 O OD1 . ASN A 1 346 ? 57.928 111.171 30.114 1.00 37.76 ? 346 ASN M OD1 1 ATOM 2742 N ND2 . ASN A 1 346 ? 59.572 112.545 29.428 1.00 45.73 ? 346 ASN M ND2 1 ATOM 2743 N N . HIS A 1 347 ? 57.691 108.654 32.328 1.00 14.92 ? 347 HIS M N 1 ATOM 2744 C CA . HIS A 1 347 ? 56.319 108.297 32.671 1.00 11.82 ? 347 HIS M CA 1 ATOM 2745 C C . HIS A 1 347 ? 56.102 108.310 34.175 1.00 12.81 ? 347 HIS M C 1 ATOM 2746 O O . HIS A 1 347 ? 56.958 107.869 34.941 1.00 13.57 ? 347 HIS M O 1 ATOM 2747 C CB . HIS A 1 347 ? 55.945 106.912 32.139 1.00 11.89 ? 347 HIS M CB 1 ATOM 2748 C CG . HIS A 1 347 ? 54.535 106.517 32.446 1.00 10.15 ? 347 HIS M CG 1 ATOM 2749 N ND1 . HIS A 1 347 ? 54.207 105.613 33.446 1.00 10.12 ? 347 HIS M ND1 1 ATOM 2750 C CD2 . HIS A 1 347 ? 53.359 106.913 31.912 1.00 9.32 ? 347 HIS M CD2 1 ATOM 2751 C CE1 . HIS A 1 347 ? 52.900 105.478 33.502 1.00 11.13 ? 347 HIS M CE1 1 ATOM 2752 N NE2 . HIS A 1 347 ? 52.355 106.258 32.579 1.00 10.83 ? 347 HIS M NE2 1 ATOM 2753 N N . THR A 1 348 ? 54.955 108.829 34.590 1.00 10.94 ? 348 THR M N 1 ATOM 2754 C CA . THR A 1 348 ? 54.611 108.864 36.004 1.00 9.88 ? 348 THR M CA 1 ATOM 2755 C C . THR A 1 348 ? 53.259 108.194 36.177 1.00 10.33 ? 348 THR M C 1 ATOM 2756 O O . THR A 1 348 ? 52.474 108.103 35.233 1.00 10.15 ? 348 THR M O 1 ATOM 2757 C CB . THR A 1 348 ? 54.509 110.302 36.565 1.00 11.29 ? 348 THR M CB 1 ATOM 2758 O OG1 . THR A 1 348 ? 53.369 110.963 36.004 1.00 11.98 ? 348 THR M OG1 1 ATOM 2759 C CG2 . THR A 1 348 ? 55.767 111.098 36.260 1.00 12.68 ? 348 THR M CG2 1 ATOM 2760 N N . ALA A 1 349 ? 52.993 107.725 37.389 1.00 9.87 ? 349 ALA M N 1 ATOM 2761 C CA . ALA A 1 349 ? 51.727 107.075 37.689 1.00 9.63 ? 349 ALA M CA 1 ATOM 2762 C C . ALA A 1 349 ? 50.565 108.029 37.423 1.00 8.00 ? 349 ALA M C 1 ATOM 2763 O O . ALA A 1 349 ? 49.494 107.610 36.986 1.00 9.18 ? 349 ALA M O 1 ATOM 2764 C CB . ALA A 1 349 ? 51.714 106.631 39.132 1.00 8.56 ? 349 ALA M CB 1 ATOM 2765 N N . MET A 1 350 ? 50.800 109.319 37.656 1.00 8.91 ? 350 MET M N 1 ATOM 2766 C CA . MET A 1 350 ? 49.776 110.338 37.459 1.00 12.75 ? 350 MET M CA 1 ATOM 2767 C C . MET A 1 350 ? 49.296 110.441 36.008 1.00 11.59 ? 350 MET M C 1 ATOM 2768 O O . MET A 1 350 ? 48.172 110.876 35.752 1.00 14.11 ? 350 MET M O 1 ATOM 2769 C CB . MET A 1 350 ? 50.277 111.697 37.955 1.00 14.26 ? 350 MET M CB 1 ATOM 2770 C CG . MET A 1 350 ? 50.575 111.754 39.457 1.00 15.28 ? 350 MET M CG 1 ATOM 2771 S SD . MET A 1 350 ? 52.160 111.012 39.936 1.00 11.96 ? 350 MET M SD 1 ATOM 2772 C CE . MET A 1 350 ? 53.255 112.384 39.645 1.00 14.03 ? 350 MET M CE 1 ATOM 2773 N N . MET A 1 351 ? 50.136 110.018 35.067 1.00 9.66 ? 351 MET M N 1 ATOM 2774 C CA . MET A 1 351 ? 49.781 110.055 33.648 1.00 10.32 ? 351 MET M CA 1 ATOM 2775 C C . MET A 1 351 ? 48.784 108.963 33.284 1.00 9.02 ? 351 MET M C 1 ATOM 2776 O O . MET A 1 351 ? 48.076 109.073 32.281 1.00 9.03 ? 351 MET M O 1 ATOM 2777 C CB . MET A 1 351 ? 51.029 109.895 32.783 1.00 10.80 ? 351 MET M CB 1 ATOM 2778 C CG . MET A 1 351 ? 52.007 111.036 32.908 1.00 12.20 ? 351 MET M CG 1 ATOM 2779 S SD . MET A 1 351 ? 53.471 110.682 31.953 1.00 15.40 ? 351 MET M SD 1 ATOM 2780 C CE . MET A 1 351 ? 54.475 112.116 32.325 1.00 16.71 ? 351 MET M CE 1 ATOM 2781 N N . ASP A 1 352 ? 48.722 107.918 34.107 1.00 9.13 ? 352 ASP M N 1 ATOM 2782 C CA . ASP A 1 352 ? 47.816 106.802 33.860 1.00 9.19 ? 352 ASP M CA 1 ATOM 2783 C C . ASP A 1 352 ? 46.347 107.199 33.754 1.00 10.13 ? 352 ASP M C 1 ATOM 2784 O O . ASP A 1 352 ? 45.581 106.545 33.053 1.00 10.42 ? 352 ASP M O 1 ATOM 2785 C CB . ASP A 1 352 ? 48.001 105.703 34.912 1.00 9.30 ? 352 ASP M CB 1 ATOM 2786 C CG . ASP A 1 352 ? 49.310 104.940 34.740 1.00 10.36 ? 352 ASP M CG 1 ATOM 2787 O OD1 . ASP A 1 352 ? 49.683 104.629 33.588 1.00 10.00 ? 352 ASP M OD1 1 ATOM 2788 O OD2 . ASP A 1 352 ? 49.970 104.643 35.755 1.00 9.66 ? 352 ASP M OD2 1 ATOM 2789 N N . ALA A 1 353 ? 45.956 108.278 34.426 1.00 8.68 ? 353 ALA M N 1 ATOM 2790 C CA . ALA A 1 353 ? 44.569 108.739 34.368 1.00 9.35 ? 353 ALA M CA 1 ATOM 2791 C C . ALA A 1 353 ? 44.190 109.221 32.969 1.00 10.56 ? 353 ALA M C 1 ATOM 2792 O O . ALA A 1 353 ? 43.004 109.303 32.635 1.00 11.92 ? 353 ALA M O 1 ATOM 2793 C CB . ALA A 1 353 ? 44.328 109.841 35.392 1.00 11.93 ? 353 ALA M CB 1 ATOM 2794 N N . GLY A 1 354 ? 45.198 109.546 32.161 1.00 9.35 ? 354 GLY M N 1 ATOM 2795 C CA . GLY A 1 354 ? 44.953 110.014 30.805 1.00 10.90 ? 354 GLY M CA 1 ATOM 2796 C C . GLY A 1 354 ? 44.178 111.316 30.782 1.00 11.90 ? 354 GLY M C 1 ATOM 2797 O O . GLY A 1 354 ? 43.304 111.524 29.938 1.00 11.41 ? 354 GLY M O 1 ATOM 2798 N N . ALA A 1 355 ? 44.516 112.211 31.704 1.00 10.74 ? 355 ALA M N 1 ATOM 2799 C CA . ALA A 1 355 ? 43.827 113.485 31.788 1.00 9.70 ? 355 ALA M CA 1 ATOM 2800 C C . ALA A 1 355 ? 44.750 114.630 32.160 1.00 10.73 ? 355 ALA M C 1 ATOM 2801 O O . ALA A 1 355 ? 45.726 114.448 32.887 1.00 13.64 ? 355 ALA M O 1 ATOM 2802 C CB . ALA A 1 355 ? 42.686 113.393 32.798 1.00 12.17 ? 355 ALA M CB 1 ATOM 2803 N N . LYS A 1 356 ? 44.457 115.793 31.588 1.00 10.41 ? 356 LYS M N 1 ATOM 2804 C CA . LYS A 1 356 ? 45.182 117.024 31.860 1.00 9.89 ? 356 LYS M CA 1 ATOM 2805 C C . LYS A 1 356 ? 44.200 117.866 32.672 1.00 9.61 ? 356 LYS M C 1 ATOM 2806 O O . LYS A 1 356 ? 43.015 117.959 32.333 1.00 9.77 ? 356 LYS M O 1 ATOM 2807 C CB . LYS A 1 356 ? 45.548 117.738 30.559 1.00 13.89 ? 356 LYS M CB 1 ATOM 2808 C CG . LYS A 1 356 ? 46.132 119.133 30.760 1.00 17.90 ? 356 LYS M CG 1 ATOM 2809 C CD . LYS A 1 356 ? 46.491 119.776 29.429 1.00 21.61 ? 356 LYS M CD 1 ATOM 2810 C CE . LYS A 1 356 ? 46.990 121.201 29.622 1.00 26.28 ? 356 LYS M CE 1 ATOM 2811 N NZ . LYS A 1 356 ? 47.384 121.818 28.326 1.00 29.31 ? 356 LYS M NZ 1 ATOM 2812 N N . LEU A 1 357 ? 44.696 118.467 33.746 1.00 8.20 ? 357 LEU M N 1 ATOM 2813 C CA . LEU A 1 357 ? 43.864 119.261 34.644 1.00 8.96 ? 357 LEU M CA 1 ATOM 2814 C C . LEU A 1 357 ? 44.134 120.753 34.537 1.00 9.38 ? 357 LEU M C 1 ATOM 2815 O O . LEU A 1 357 ? 45.289 121.182 34.473 1.00 10.93 ? 357 LEU M O 1 ATOM 2816 C CB . LEU A 1 357 ? 44.090 118.795 36.088 1.00 8.39 ? 357 LEU M CB 1 ATOM 2817 C CG . LEU A 1 357 ? 43.913 117.289 36.309 1.00 10.53 ? 357 LEU M CG 1 ATOM 2818 C CD1 . LEU A 1 357 ? 44.369 116.902 37.709 1.00 11.81 ? 357 LEU M CD1 1 ATOM 2819 C CD2 . LEU A 1 357 ? 42.461 116.894 36.080 1.00 9.99 ? 357 LEU M CD2 1 ATOM 2820 N N . THR A 1 358 ? 43.061 121.539 34.540 1.00 8.49 ? 358 THR M N 1 ATOM 2821 C CA . THR A 1 358 ? 43.160 122.992 34.446 1.00 9.82 ? 358 THR M CA 1 ATOM 2822 C C . THR A 1 358 ? 42.099 123.633 35.334 1.00 10.24 ? 358 THR M C 1 ATOM 2823 O O . THR A 1 358 ? 41.225 122.949 35.871 1.00 9.46 ? 358 THR M O 1 ATOM 2824 C CB . THR A 1 358 ? 42.904 123.493 33.001 1.00 9.06 ? 358 THR M CB 1 ATOM 2825 O OG1 . THR A 1 358 ? 41.578 123.128 32.599 1.00 11.05 ? 358 THR M OG1 1 ATOM 2826 C CG2 . THR A 1 358 ? 43.916 122.906 32.024 1.00 10.26 ? 358 THR M CG2 1 ATOM 2827 N N . TYR A 1 359 ? 42.191 124.951 35.488 1.00 8.95 ? 359 TYR M N 1 ATOM 2828 C CA . TYR A 1 359 ? 41.224 125.704 36.278 1.00 7.74 ? 359 TYR M CA 1 ATOM 2829 C C . TYR A 1 359 ? 40.405 126.596 35.360 1.00 7.90 ? 359 TYR M C 1 ATOM 2830 O O . TYR A 1 359 ? 39.553 127.350 35.818 1.00 9.10 ? 359 TYR M O 1 ATOM 2831 C CB . TYR A 1 359 ? 41.935 126.549 37.336 1.00 8.67 ? 359 TYR M CB 1 ATOM 2832 C CG . TYR A 1 359 ? 42.656 125.698 38.343 1.00 8.79 ? 359 TYR M CG 1 ATOM 2833 C CD1 . TYR A 1 359 ? 41.956 125.061 39.366 1.00 9.19 ? 359 TYR M CD1 1 ATOM 2834 C CD2 . TYR A 1 359 ? 44.023 125.455 38.224 1.00 11.81 ? 359 TYR M CD2 1 ATOM 2835 C CE1 . TYR A 1 359 ? 42.596 124.201 40.244 1.00 11.72 ? 359 TYR M CE1 1 ATOM 2836 C CE2 . TYR A 1 359 ? 44.675 124.595 39.098 1.00 13.58 ? 359 TYR M CE2 1 ATOM 2837 C CZ . TYR A 1 359 ? 43.953 123.969 40.101 1.00 15.10 ? 359 TYR M CZ 1 ATOM 2838 O OH . TYR A 1 359 ? 44.586 123.104 40.954 1.00 15.97 ? 359 TYR M OH 1 ATOM 2839 N N . ILE A 1 360 ? 40.665 126.476 34.059 1.00 9.28 ? 360 ILE M N 1 ATOM 2840 C CA . ILE A 1 360 ? 39.982 127.248 33.026 1.00 6.88 ? 360 ILE M CA 1 ATOM 2841 C C . ILE A 1 360 ? 39.412 126.242 32.033 1.00 6.63 ? 360 ILE M C 1 ATOM 2842 O O . ILE A 1 360 ? 40.102 125.297 31.654 1.00 9.57 ? 360 ILE M O 1 ATOM 2843 C CB . ILE A 1 360 ? 40.980 128.147 32.261 1.00 9.06 ? 360 ILE M CB 1 ATOM 2844 C CG1 . ILE A 1 360 ? 41.846 128.939 33.245 1.00 3.51 ? 360 ILE M CG1 1 ATOM 2845 C CG2 . ILE A 1 360 ? 40.227 129.091 31.337 1.00 1.00 ? 360 ILE M CG2 1 ATOM 2846 C CD1 . ILE A 1 360 ? 43.039 129.616 32.597 1.00 7.77 ? 360 ILE M CD1 1 ATOM 2847 N N . ASN A 1 361 ? 38.156 126.413 31.625 1.00 7.59 ? 361 ASN M N 1 ATOM 2848 C CA . ASN A 1 361 ? 37.600 125.459 30.676 1.00 8.31 ? 361 ASN M CA 1 ATOM 2849 C C . ASN A 1 361 ? 37.823 125.853 29.222 1.00 10.35 ? 361 ASN M C 1 ATOM 2850 O O . ASN A 1 361 ? 38.470 126.865 28.945 1.00 9.86 ? 361 ASN M O 1 ATOM 2851 C CB . ASN A 1 361 ? 36.142 125.087 31.005 1.00 9.02 ? 361 ASN M CB 1 ATOM 2852 C CG . ASN A 1 361 ? 35.123 126.143 30.604 1.00 9.87 ? 361 ASN M CG 1 ATOM 2853 O OD1 . ASN A 1 361 ? 35.445 127.226 30.104 1.00 10.08 ? 361 ASN M OD1 1 ATOM 2854 N ND2 . ASN A 1 361 ? 33.863 125.770 30.826 1.00 10.29 ? 361 ASN M ND2 1 ATOM 2855 N N . ALA A 1 362 ? 37.325 125.033 28.302 1.00 9.66 ? 362 ALA M N 1 ATOM 2856 C CA . ALA A 1 362 ? 37.510 125.261 26.869 1.00 12.17 ? 362 ALA M CA 1 ATOM 2857 C C . ALA A 1 362 ? 37.041 126.613 26.362 1.00 12.49 ? 362 ALA M C 1 ATOM 2858 O O . ALA A 1 362 ? 37.593 127.133 25.392 1.00 14.67 ? 362 ALA M O 1 ATOM 2859 C CB . ALA A 1 362 ? 36.847 124.143 26.067 1.00 11.47 ? 362 ALA M CB 1 ATOM 2860 N N . SER A 1 363 ? 36.018 127.170 27.002 1.00 11.92 ? 363 SER M N 1 ATOM 2861 C CA . SER A 1 363 ? 35.482 128.463 26.600 1.00 14.08 ? 363 SER M CA 1 ATOM 2862 C C . SER A 1 363 ? 36.159 129.641 27.308 1.00 15.04 ? 363 SER M C 1 ATOM 2863 O O . SER A 1 363 ? 35.729 130.782 27.163 1.00 14.60 ? 363 SER M O 1 ATOM 2864 C CB . SER A 1 363 ? 33.961 128.500 26.800 1.00 17.83 ? 363 SER M CB 1 ATOM 2865 O OG . SER A 1 363 ? 33.602 128.313 28.155 1.00 29.94 ? 363 SER M OG 1 ATOM 2866 N N . GLY A 1 364 ? 37.217 129.355 28.065 1.00 11.77 ? 364 GLY M N 1 ATOM 2867 C CA . GLY A 1 364 ? 37.947 130.403 28.765 1.00 13.23 ? 364 GLY M CA 1 ATOM 2868 C C . GLY A 1 364 ? 37.411 130.807 30.124 1.00 14.03 ? 364 GLY M C 1 ATOM 2869 O O . GLY A 1 364 ? 37.855 131.803 30.702 1.00 14.17 ? 364 GLY M O 1 ATOM 2870 N N . HIS A 1 365 ? 36.477 130.026 30.656 1.00 11.31 ? 365 HIS M N 1 ATOM 2871 C CA . HIS A 1 365 ? 35.892 130.320 31.954 1.00 10.62 ? 365 HIS M CA 1 ATOM 2872 C C . HIS A 1 365 ? 36.734 129.823 33.124 1.00 10.32 ? 365 HIS M C 1 ATOM 2873 O O . HIS A 1 365 ? 37.055 128.637 33.197 1.00 9.02 ? 365 HIS M O 1 ATOM 2874 C CB . HIS A 1 365 ? 34.495 129.698 32.045 1.00 11.49 ? 365 HIS M CB 1 ATOM 2875 C CG . HIS A 1 365 ? 33.831 129.896 33.373 1.00 13.81 ? 365 HIS M CG 1 ATOM 2876 N ND1 . HIS A 1 365 ? 33.704 128.887 34.300 1.00 16.31 ? 365 HIS M ND1 1 ATOM 2877 C CD2 . HIS A 1 365 ? 33.257 130.993 33.922 1.00 11.61 ? 365 HIS M CD2 1 ATOM 2878 C CE1 . HIS A 1 365 ? 33.075 129.353 35.368 1.00 10.28 ? 365 HIS M CE1 1 ATOM 2879 N NE2 . HIS A 1 365 ? 32.794 130.624 35.163 1.00 18.12 ? 365 HIS M NE2 1 ATOM 2880 N N . TYR A 1 366 ? 37.117 130.736 34.020 1.00 9.42 ? 366 TYR M N 1 ATOM 2881 C CA . TYR A 1 366 ? 37.867 130.358 35.217 1.00 10.52 ? 366 TYR M CA 1 ATOM 2882 C C . TYR A 1 366 ? 36.827 129.787 36.175 1.00 8.44 ? 366 TYR M C 1 ATOM 2883 O O . TYR A 1 366 ? 35.788 130.398 36.420 1.00 11.14 ? 366 TYR M O 1 ATOM 2884 C CB . TYR A 1 366 ? 38.558 131.565 35.844 1.00 10.71 ? 366 TYR M CB 1 ATOM 2885 C CG . TYR A 1 366 ? 39.852 131.945 35.164 1.00 15.61 ? 366 TYR M CG 1 ATOM 2886 C CD1 . TYR A 1 366 ? 39.857 132.569 33.919 1.00 18.34 ? 366 TYR M CD1 1 ATOM 2887 C CD2 . TYR A 1 366 ? 41.074 131.700 35.781 1.00 18.56 ? 366 TYR M CD2 1 ATOM 2888 C CE1 . TYR A 1 366 ? 41.053 132.949 33.308 1.00 18.71 ? 366 TYR M CE1 1 ATOM 2889 C CE2 . TYR A 1 366 ? 42.274 132.075 35.179 1.00 22.04 ? 366 TYR M CE2 1 ATOM 2890 C CZ . TYR A 1 366 ? 42.255 132.697 33.946 1.00 21.74 ? 366 TYR M CZ 1 ATOM 2891 O OH . TYR A 1 366 ? 43.444 133.076 33.363 1.00 23.49 ? 366 TYR M OH 1 ATOM 2892 N N . ILE A 1 367 ? 37.125 128.622 36.730 1.00 9.53 ? 367 ILE M N 1 ATOM 2893 C CA . ILE A 1 367 ? 36.197 127.919 37.608 1.00 7.68 ? 367 ILE M CA 1 ATOM 2894 C C . ILE A 1 367 ? 35.653 128.686 38.818 1.00 9.11 ? 367 ILE M C 1 ATOM 2895 O O . ILE A 1 367 ? 34.526 128.442 39.258 1.00 9.78 ? 367 ILE M O 1 ATOM 2896 C CB . ILE A 1 367 ? 36.809 126.564 38.031 1.00 7.67 ? 367 ILE M CB 1 ATOM 2897 C CG1 . ILE A 1 367 ? 35.725 125.634 38.566 1.00 9.79 ? 367 ILE M CG1 1 ATOM 2898 C CG2 . ILE A 1 367 ? 37.923 126.776 39.045 1.00 8.88 ? 367 ILE M CG2 1 ATOM 2899 C CD1 . ILE A 1 367 ? 36.198 124.200 38.702 1.00 11.11 ? 367 ILE M CD1 1 ATOM 2900 N N . GLY A 1 368 ? 36.437 129.624 39.337 1.00 8.03 ? 368 GLY M N 1 ATOM 2901 C CA . GLY A 1 368 ? 35.997 130.393 40.482 1.00 8.81 ? 368 GLY M CA 1 ATOM 2902 C C . GLY A 1 368 ? 37.039 131.414 40.883 1.00 8.34 ? 368 GLY M C 1 ATOM 2903 O O . GLY A 1 368 ? 37.950 131.706 40.102 1.00 9.92 ? 368 GLY M O 1 ATOM 2904 N N . PRO A 1 369 ? 36.941 131.966 42.103 1.00 8.98 ? 369 PRO M N 1 ATOM 2905 C CA . PRO A 1 369 ? 37.890 132.966 42.599 1.00 9.00 ? 369 PRO M CA 1 ATOM 2906 C C . PRO A 1 369 ? 39.295 132.411 42.769 1.00 9.24 ? 369 PRO M C 1 ATOM 2907 O O . PRO A 1 369 ? 39.494 131.199 42.881 1.00 9.09 ? 369 PRO M O 1 ATOM 2908 C CB . PRO A 1 369 ? 37.299 133.366 43.957 1.00 8.24 ? 369 PRO M CB 1 ATOM 2909 C CG . PRO A 1 369 ? 35.841 133.011 43.845 1.00 8.10 ? 369 PRO M CG 1 ATOM 2910 C CD . PRO A 1 369 ? 35.889 131.705 43.098 1.00 8.49 ? 369 PRO M CD 1 ATOM 2911 N N . LEU A 1 370 ? 40.270 133.314 42.790 1.00 8.62 ? 370 LEU M N 1 ATOM 2912 C CA . LEU A 1 370 ? 41.669 132.945 42.962 1.00 8.64 ? 370 LEU M CA 1 ATOM 2913 C C . LEU A 1 370 ? 41.877 132.212 44.285 1.00 9.77 ? 370 LEU M C 1 ATOM 2914 O O . LEU A 1 370 ? 41.365 132.630 45.328 1.00 10.60 ? 370 LEU M O 1 ATOM 2915 C CB . LEU A 1 370 ? 42.544 134.203 42.934 1.00 9.38 ? 370 LEU M CB 1 ATOM 2916 C CG . LEU A 1 370 ? 44.052 134.009 43.104 1.00 12.04 ? 370 LEU M CG 1 ATOM 2917 C CD1 . LEU A 1 370 ? 44.636 133.310 41.884 1.00 13.99 ? 370 LEU M CD1 1 ATOM 2918 C CD2 . LEU A 1 370 ? 44.714 135.365 43.307 1.00 14.45 ? 370 LEU M CD2 1 ATOM 2919 N N . PHE A 1 371 ? 42.613 131.106 44.226 1.00 8.71 ? 371 PHE M N 1 ATOM 2920 C CA . PHE A 1 371 ? 42.915 130.308 45.411 1.00 9.59 ? 371 PHE M CA 1 ATOM 2921 C C . PHE A 1 371 ? 44.375 130.519 45.797 1.00 13.07 ? 371 PHE M C 1 ATOM 2922 O O . PHE A 1 371 ? 44.694 130.746 46.964 1.00 13.04 ? 371 PHE M O 1 ATOM 2923 C CB . PHE A 1 371 ? 42.660 128.825 45.131 1.00 8.89 ? 371 PHE M CB 1 ATOM 2924 C CG . PHE A 1 371 ? 42.966 127.927 46.298 1.00 10.06 ? 371 PHE M CG 1 ATOM 2925 C CD1 . PHE A 1 371 ? 42.092 127.846 47.375 1.00 8.32 ? 371 PHE M CD1 1 ATOM 2926 C CD2 . PHE A 1 371 ? 44.126 127.164 46.320 1.00 12.67 ? 371 PHE M CD2 1 ATOM 2927 C CE1 . PHE A 1 371 ? 42.372 127.022 48.461 1.00 8.43 ? 371 PHE M CE1 1 ATOM 2928 C CE2 . PHE A 1 371 ? 44.417 126.337 47.400 1.00 13.16 ? 371 PHE M CE2 1 ATOM 2929 C CZ . PHE A 1 371 ? 43.537 126.265 48.472 1.00 9.73 ? 371 PHE M CZ 1 ATOM 2930 N N . GLU A 1 372 ? 45.260 130.431 44.808 1.00 14.39 ? 372 GLU M N 1 ATOM 2931 C CA . GLU A 1 372 ? 46.685 130.620 45.041 1.00 16.37 ? 372 GLU M CA 1 ATOM 2932 C C . GLU A 1 372 ? 47.363 131.188 43.804 1.00 18.96 ? 372 GLU M C 1 ATOM 2933 O O . GLU A 1 372 ? 47.277 130.619 42.716 1.00 15.31 ? 372 GLU M O 1 ATOM 2934 C CB . GLU A 1 372 ? 47.348 129.299 45.443 1.00 20.32 ? 372 GLU M CB 1 ATOM 2935 C CG . GLU A 1 372 ? 48.852 129.415 45.686 1.00 27.17 ? 372 GLU M CG 1 ATOM 2936 C CD . GLU A 1 372 ? 49.484 128.118 46.152 1.00 30.18 ? 372 GLU M CD 1 ATOM 2937 O OE1 . GLU A 1 372 ? 49.137 127.042 45.618 1.00 32.59 ? 372 GLU M OE1 1 ATOM 2938 O OE2 . GLU A 1 372 ? 50.338 128.174 47.061 1.00 36.63 ? 372 GLU M OE2 1 ATOM 2939 N N . LYS A 1 373 ? 48.012 132.335 43.979 1.00 23.35 ? 373 LYS M N 1 ATOM 2940 C CA . LYS A 1 373 ? 48.726 132.998 42.897 1.00 30.03 ? 373 LYS M CA 1 ATOM 2941 C C . LYS A 1 373 ? 50.149 132.457 42.799 1.00 34.42 ? 373 LYS M C 1 ATOM 2942 O O . LYS A 1 373 ? 50.883 132.430 43.788 1.00 35.28 ? 373 LYS M O 1 ATOM 2943 C CB . LYS A 1 373 ? 48.752 134.514 43.129 1.00 33.04 ? 373 LYS M CB 1 ATOM 2944 C CG . LYS A 1 373 ? 49.688 135.282 42.200 1.00 36.54 ? 373 LYS M CG 1 ATOM 2945 C CD . LYS A 1 373 ? 49.277 135.146 40.746 1.00 39.15 ? 373 LYS M CD 1 ATOM 2946 C CE . LYS A 1 373 ? 50.407 135.547 39.812 1.00 40.89 ? 373 LYS M CE 1 ATOM 2947 N NZ . LYS A 1 373 ? 50.015 135.412 38.383 1.00 42.50 ? 373 LYS M NZ 1 ATOM 2948 N N . ASP A 1 374 ? 50.516 131.999 41.606 1.00 38.34 ? 374 ASP M N 1 ATOM 2949 C CA . ASP A 1 374 ? 51.849 131.468 41.352 1.00 43.55 ? 374 ASP M CA 1 ATOM 2950 C C . ASP A 1 374 ? 52.673 132.566 40.679 1.00 45.26 ? 374 ASP M C 1 ATOM 2951 O O . ASP A 1 374 ? 52.410 132.939 39.534 1.00 44.91 ? 374 ASP M O 1 ATOM 2952 C CB . ASP A 1 374 ? 51.761 130.235 40.442 1.00 45.59 ? 374 ASP M CB 1 ATOM 2953 C CG . ASP A 1 374 ? 53.074 129.459 40.354 1.00 49.03 ? 374 ASP M CG 1 ATOM 2954 O OD1 . ASP A 1 374 ? 54.154 130.039 40.597 1.00 50.25 ? 374 ASP M OD1 1 ATOM 2955 O OD2 . ASP A 1 374 ? 53.021 128.253 40.035 1.00 50.93 ? 374 ASP M OD2 1 ATOM 2956 N N . LYS A 1 375 ? 53.661 133.085 41.403 1.00 48.65 ? 375 LYS M N 1 ATOM 2957 C CA . LYS A 1 375 ? 54.527 134.143 40.888 1.00 51.62 ? 375 LYS M CA 1 ATOM 2958 C C . LYS A 1 375 ? 55.430 133.681 39.747 1.00 52.40 ? 375 LYS M C 1 ATOM 2959 O O . LYS A 1 375 ? 55.733 134.455 38.837 1.00 53.13 ? 375 LYS M O 1 ATOM 2960 C CB . LYS A 1 375 ? 55.376 134.735 42.015 1.00 52.25 ? 375 LYS M CB 1 ATOM 2961 C CG . LYS A 1 375 ? 54.605 135.640 42.964 1.00 53.84 ? 375 LYS M CG 1 ATOM 2962 C CD . LYS A 1 375 ? 54.059 136.859 42.232 1.00 55.22 ? 375 LYS M CD 1 ATOM 2963 C CE . LYS A 1 375 ? 53.337 137.804 43.178 1.00 56.02 ? 375 LYS M CE 1 ATOM 2964 N NZ . LYS A 1 375 ? 54.241 138.353 44.229 1.00 56.52 ? 375 LYS M NZ 1 ATOM 2965 N N . ALA A 1 376 ? 55.849 132.419 39.799 1.00 54.00 ? 376 ALA M N 1 ATOM 2966 C CA . ALA A 1 376 ? 56.716 131.843 38.774 1.00 54.85 ? 376 ALA M CA 1 ATOM 2967 C C . ALA A 1 376 ? 56.023 131.777 37.414 1.00 55.86 ? 376 ALA M C 1 ATOM 2968 O O . ALA A 1 376 ? 56.669 131.924 36.375 1.00 56.77 ? 376 ALA M O 1 ATOM 2969 C CB . ALA A 1 376 ? 57.179 130.454 39.197 1.00 54.96 ? 376 ALA M CB 1 ATOM 2970 N N . ASP A 1 377 ? 54.709 131.567 37.430 1.00 56.00 ? 377 ASP M N 1 ATOM 2971 C CA . ASP A 1 377 ? 53.926 131.484 36.201 1.00 55.95 ? 377 ASP M CA 1 ATOM 2972 C C . ASP A 1 377 ? 52.455 131.793 36.479 1.00 55.25 ? 377 ASP M C 1 ATOM 2973 O O . ASP A 1 377 ? 51.814 131.129 37.295 1.00 55.63 ? 377 ASP M O 1 ATOM 2974 C CB . ASP A 1 377 ? 54.074 130.090 35.577 1.00 55.78 ? 377 ASP M CB 1 ATOM 2975 C CG . ASP A 1 377 ? 53.493 130.000 34.169 1.00 56.46 ? 377 ASP M CG 1 ATOM 2976 O OD1 . ASP A 1 377 ? 53.086 131.036 33.598 1.00 56.91 ? 377 ASP M OD1 1 ATOM 2977 O OD2 . ASP A 1 377 ? 53.453 128.876 33.626 1.00 56.92 ? 377 ASP M OD2 1 ATOM 2978 N N . SER A 1 378 ? 51.932 132.803 35.787 1.00 54.50 ? 378 SER M N 1 ATOM 2979 C CA . SER A 1 378 ? 50.542 133.228 35.939 1.00 53.51 ? 378 SER M CA 1 ATOM 2980 C C . SER A 1 378 ? 49.549 132.145 35.532 1.00 52.38 ? 378 SER M C 1 ATOM 2981 O O . SER A 1 378 ? 48.486 132.009 36.138 1.00 52.00 ? 378 SER M O 1 ATOM 2982 C CB . SER A 1 378 ? 50.277 134.488 35.110 1.00 55.09 ? 378 SER M CB 1 ATOM 2983 O OG . SER A 1 378 ? 51.105 135.561 35.520 1.00 57.10 ? 378 SER M OG 1 ATOM 2984 N N . THR A 1 379 ? 49.901 131.382 34.501 1.00 50.29 ? 379 THR M N 1 ATOM 2985 C CA . THR A 1 379 ? 49.043 130.312 33.999 1.00 48.12 ? 379 THR M CA 1 ATOM 2986 C C . THR A 1 379 ? 49.002 129.098 34.931 1.00 46.18 ? 379 THR M C 1 ATOM 2987 O O . THR A 1 379 ? 48.292 128.126 34.663 1.00 46.33 ? 379 THR M O 1 ATOM 2988 C CB . THR A 1 379 ? 49.486 129.856 32.591 1.00 48.42 ? 379 THR M CB 1 ATOM 2989 O OG1 . THR A 1 379 ? 50.808 129.307 32.653 1.00 48.54 ? 379 THR M OG1 1 ATOM 2990 C CG2 . THR A 1 379 ? 49.479 131.033 31.623 1.00 49.11 ? 379 THR M CG2 1 ATOM 2991 N N . ASP A 1 380 ? 49.767 129.158 36.019 1.00 42.66 ? 380 ASP M N 1 ATOM 2992 C CA . ASP A 1 380 ? 49.818 128.068 36.992 1.00 38.81 ? 380 ASP M CA 1 ATOM 2993 C C . ASP A 1 380 ? 49.065 128.399 38.283 1.00 32.85 ? 380 ASP M C 1 ATOM 2994 O O . ASP A 1 380 ? 49.227 127.721 39.300 1.00 31.28 ? 380 ASP M O 1 ATOM 2995 C CB . ASP A 1 380 ? 51.273 127.705 37.314 1.00 42.33 ? 380 ASP M CB 1 ATOM 2996 C CG . ASP A 1 380 ? 52.019 127.127 36.119 1.00 45.84 ? 380 ASP M CG 1 ATOM 2997 O OD1 . ASP A 1 380 ? 51.385 126.835 35.080 1.00 48.85 ? 380 ASP M OD1 1 ATOM 2998 O OD2 . ASP A 1 380 ? 53.253 126.961 36.221 1.00 48.16 ? 380 ASP M OD2 1 ATOM 2999 N N . ASN A 1 381 ? 48.251 129.450 38.239 1.00 27.38 ? 381 ASN M N 1 ATOM 3000 C CA . ASN A 1 381 ? 47.463 129.864 39.396 1.00 20.15 ? 381 ASN M CA 1 ATOM 3001 C C . ASN A 1 381 ? 46.366 128.845 39.673 1.00 18.86 ? 381 ASN M C 1 ATOM 3002 O O . ASN A 1 381 ? 45.872 128.193 38.757 1.00 18.09 ? 381 ASN M O 1 ATOM 3003 C CB . ASN A 1 381 ? 46.797 131.215 39.141 1.00 21.82 ? 381 ASN M CB 1 ATOM 3004 C CG . ASN A 1 381 ? 47.779 132.366 39.103 1.00 21.20 ? 381 ASN M CG 1 ATOM 3005 O OD1 . ASN A 1 381 ? 48.966 132.205 39.387 1.00 22.80 ? 381 ASN M OD1 1 ATOM 3006 N ND2 . ASN A 1 381 ? 47.279 133.545 38.758 1.00 23.39 ? 381 ASN M ND2 1 ATOM 3007 N N . ILE A 1 382 ? 45.989 128.717 40.941 1.00 12.64 ? 382 ILE M N 1 ATOM 3008 C CA . ILE A 1 382 ? 44.924 127.800 41.334 1.00 11.25 ? 382 ILE M CA 1 ATOM 3009 C C . ILE A 1 382 ? 43.697 128.643 41.658 1.00 9.58 ? 382 ILE M C 1 ATOM 3010 O O . ILE A 1 382 ? 43.819 129.728 42.219 1.00 8.58 ? 382 ILE M O 1 ATOM 3011 C CB . ILE A 1 382 ? 45.313 126.979 42.581 1.00 12.09 ? 382 ILE M CB 1 ATOM 3012 C CG1 . ILE A 1 382 ? 46.564 126.144 42.291 1.00 14.09 ? 382 ILE M CG1 1 ATOM 3013 C CG2 . ILE A 1 382 ? 44.164 126.054 42.991 1.00 11.28 ? 382 ILE M CG2 1 ATOM 3014 C CD1 . ILE A 1 382 ? 47.054 125.353 43.483 1.00 14.89 ? 382 ILE M CD1 1 ATOM 3015 N N . TYR A 1 383 ? 42.522 128.149 41.283 1.00 8.80 ? 383 TYR M N 1 ATOM 3016 C CA . TYR A 1 383 ? 41.269 128.846 41.543 1.00 8.03 ? 383 TYR M CA 1 ATOM 3017 C C . TYR A 1 383 ? 40.350 127.881 42.264 1.00 8.58 ? 383 TYR M C 1 ATOM 3018 O O . TYR A 1 383 ? 40.455 126.671 42.066 1.00 8.99 ? 383 TYR M O 1 ATOM 3019 C CB . TYR A 1 383 ? 40.635 129.317 40.234 1.00 8.89 ? 383 TYR M CB 1 ATOM 3020 C CG . TYR A 1 383 ? 41.490 130.340 39.536 1.00 8.52 ? 383 TYR M CG 1 ATOM 3021 C CD1 . TYR A 1 383 ? 42.585 129.949 38.770 1.00 10.68 ? 383 TYR M CD1 1 ATOM 3022 C CD2 . TYR A 1 383 ? 41.266 131.703 39.722 1.00 10.30 ? 383 TYR M CD2 1 ATOM 3023 C CE1 . TYR A 1 383 ? 43.443 130.887 38.212 1.00 14.01 ? 383 TYR M CE1 1 ATOM 3024 C CE2 . TYR A 1 383 ? 42.119 132.653 39.164 1.00 13.86 ? 383 TYR M CE2 1 ATOM 3025 C CZ . TYR A 1 383 ? 43.206 132.236 38.418 1.00 14.56 ? 383 TYR M CZ 1 ATOM 3026 O OH . TYR A 1 383 ? 44.074 133.168 37.894 1.00 17.32 ? 383 TYR M OH 1 ATOM 3027 N N . TYR A 1 384 ? 39.487 128.403 43.128 1.00 7.17 ? 384 TYR M N 1 ATOM 3028 C CA . TYR A 1 384 ? 38.582 127.531 43.866 1.00 5.92 ? 384 TYR M CA 1 ATOM 3029 C C . TYR A 1 384 ? 37.174 127.477 43.303 1.00 6.58 ? 384 TYR M C 1 ATOM 3030 O O . TYR A 1 384 ? 36.830 128.237 42.400 1.00 9.43 ? 384 TYR M O 1 ATOM 3031 C CB . TYR A 1 384 ? 38.616 127.802 45.376 1.00 6.57 ? 384 TYR M CB 1 ATOM 3032 C CG . TYR A 1 384 ? 38.090 129.132 45.860 1.00 7.76 ? 384 TYR M CG 1 ATOM 3033 C CD1 . TYR A 1 384 ? 36.757 129.268 46.242 1.00 7.86 ? 384 TYR M CD1 1 ATOM 3034 C CD2 . TYR A 1 384 ? 38.947 130.219 46.054 1.00 6.19 ? 384 TYR M CD2 1 ATOM 3035 C CE1 . TYR A 1 384 ? 36.287 130.440 46.820 1.00 8.01 ? 384 TYR M CE1 1 ATOM 3036 C CE2 . TYR A 1 384 ? 38.486 131.406 46.635 1.00 6.70 ? 384 TYR M CE2 1 ATOM 3037 C CZ . TYR A 1 384 ? 37.157 131.504 47.018 1.00 8.45 ? 384 TYR M CZ 1 ATOM 3038 O OH . TYR A 1 384 ? 36.693 132.642 47.635 1.00 8.70 ? 384 TYR M OH 1 ATOM 3039 N N . TYR A 1 385 ? 36.353 126.608 43.883 1.00 6.19 ? 385 TYR M N 1 ATOM 3040 C CA . TYR A 1 385 ? 35.006 126.358 43.393 1.00 8.60 ? 385 TYR M CA 1 ATOM 3041 C C . TYR A 1 385 ? 34.175 125.874 44.582 1.00 8.03 ? 385 TYR M C 1 ATOM 3042 O O . TYR A 1 385 ? 34.151 124.681 44.889 1.00 7.77 ? 385 TYR M O 1 ATOM 3043 C CB . TYR A 1 385 ? 35.141 125.267 42.322 1.00 8.71 ? 385 TYR M CB 1 ATOM 3044 C CG . TYR A 1 385 ? 33.869 124.752 41.700 1.00 8.94 ? 385 TYR M CG 1 ATOM 3045 C CD1 . TYR A 1 385 ? 33.096 125.559 40.874 1.00 8.09 ? 385 TYR M CD1 1 ATOM 3046 C CD2 . TYR A 1 385 ? 33.468 123.433 41.898 1.00 7.59 ? 385 TYR M CD2 1 ATOM 3047 C CE1 . TYR A 1 385 ? 31.956 125.063 40.258 1.00 10.53 ? 385 TYR M CE1 1 ATOM 3048 C CE2 . TYR A 1 385 ? 32.330 122.926 41.288 1.00 8.95 ? 385 TYR M CE2 1 ATOM 3049 C CZ . TYR A 1 385 ? 31.579 123.749 40.468 1.00 10.01 ? 385 TYR M CZ 1 ATOM 3050 O OH . TYR A 1 385 ? 30.449 123.260 39.852 1.00 9.28 ? 385 TYR M OH 1 ATOM 3051 N N . PRO A 1 386 ? 33.479 126.803 45.263 1.00 8.60 ? 386 PRO M N 1 ATOM 3052 C CA . PRO A 1 386 ? 32.655 126.473 46.431 1.00 8.68 ? 386 PRO M CA 1 ATOM 3053 C C . PRO A 1 386 ? 31.688 125.314 46.255 1.00 8.18 ? 386 PRO M C 1 ATOM 3054 O O . PRO A 1 386 ? 31.540 124.499 47.162 1.00 9.24 ? 386 PRO M O 1 ATOM 3055 C CB . PRO A 1 386 ? 31.941 127.790 46.732 1.00 9.65 ? 386 PRO M CB 1 ATOM 3056 C CG . PRO A 1 386 ? 32.953 128.819 46.290 1.00 10.12 ? 386 PRO M CG 1 ATOM 3057 C CD . PRO A 1 386 ? 33.407 128.246 44.968 1.00 7.37 ? 386 PRO M CD 1 ATOM 3058 N N . LYS A 1 387 ? 31.056 125.220 45.091 1.00 8.37 ? 387 LYS M N 1 ATOM 3059 C CA . LYS A 1 387 ? 30.109 124.138 44.831 1.00 8.09 ? 387 LYS M CA 1 ATOM 3060 C C . LYS A 1 387 ? 30.781 122.766 44.852 1.00 9.31 ? 387 LYS M C 1 ATOM 3061 O O . LYS A 1 387 ? 30.118 121.744 45.035 1.00 9.73 ? 387 LYS M O 1 ATOM 3062 C CB . LYS A 1 387 ? 29.395 124.357 43.495 1.00 10.74 ? 387 LYS M CB 1 ATOM 3063 C CG . LYS A 1 387 ? 28.296 123.341 43.212 1.00 14.32 ? 387 LYS M CG 1 ATOM 3064 C CD . LYS A 1 387 ? 27.529 123.692 41.948 1.00 20.86 ? 387 LYS M CD 1 ATOM 3065 C CE . LYS A 1 387 ? 26.458 122.650 41.660 1.00 24.53 ? 387 LYS M CE 1 ATOM 3066 N NZ . LYS A 1 387 ? 25.685 122.974 40.427 1.00 30.37 ? 387 LYS M NZ 1 ATOM 3067 N N . GLY A 1 388 ? 32.100 122.754 44.685 1.00 8.89 ? 388 GLY M N 1 ATOM 3068 C CA . GLY A 1 388 ? 32.841 121.506 44.690 1.00 7.84 ? 388 GLY M CA 1 ATOM 3069 C C . GLY A 1 388 ? 32.654 120.699 45.961 1.00 6.83 ? 388 GLY M C 1 ATOM 3070 O O . GLY A 1 388 ? 32.611 119.473 45.908 1.00 9.09 ? 388 GLY M O 1 ATOM 3071 N N . ILE A 1 389 ? 32.543 121.366 47.106 1.00 6.88 ? 389 ILE M N 1 ATOM 3072 C CA . ILE A 1 389 ? 32.367 120.629 48.352 1.00 8.40 ? 389 ILE M CA 1 ATOM 3073 C C . ILE A 1 389 ? 30.995 119.945 48.370 1.00 8.25 ? 389 ILE M C 1 ATOM 3074 O O . ILE A 1 389 ? 30.848 118.849 48.914 1.00 9.04 ? 389 ILE M O 1 ATOM 3075 C CB . ILE A 1 389 ? 32.614 121.521 49.594 1.00 8.34 ? 389 ILE M CB 1 ATOM 3076 C CG1 . ILE A 1 389 ? 32.894 120.641 50.814 1.00 8.56 ? 389 ILE M CG1 1 ATOM 3077 C CG2 . ILE A 1 389 ? 31.434 122.443 49.849 1.00 8.65 ? 389 ILE M CG2 1 ATOM 3078 C CD1 . ILE A 1 389 ? 33.395 121.415 52.018 1.00 10.42 ? 389 ILE M CD1 1 ATOM 3079 N N . TYR A 1 390 ? 30.003 120.581 47.748 1.00 7.98 ? 390 TYR M N 1 ATOM 3080 C CA . TYR A 1 390 ? 28.653 120.013 47.657 1.00 8.73 ? 390 TYR M CA 1 ATOM 3081 C C . TYR A 1 390 ? 28.730 118.769 46.769 1.00 8.76 ? 390 TYR M C 1 ATOM 3082 O O . TYR A 1 390 ? 28.284 117.682 47.147 1.00 7.94 ? 390 TYR M O 1 ATOM 3083 C CB . TYR A 1 390 ? 27.697 121.048 47.042 1.00 8.88 ? 390 TYR M CB 1 ATOM 3084 C CG . TYR A 1 390 ? 26.264 120.590 46.831 1.00 9.61 ? 390 TYR M CG 1 ATOM 3085 C CD1 . TYR A 1 390 ? 25.930 119.720 45.793 1.00 12.37 ? 390 TYR M CD1 1 ATOM 3086 C CD2 . TYR A 1 390 ? 25.236 121.066 47.644 1.00 10.83 ? 390 TYR M CD2 1 ATOM 3087 C CE1 . TYR A 1 390 ? 24.606 119.338 45.564 1.00 14.34 ? 390 TYR M CE1 1 ATOM 3088 C CE2 . TYR A 1 390 ? 23.906 120.691 47.423 1.00 13.15 ? 390 TYR M CE2 1 ATOM 3089 C CZ . TYR A 1 390 ? 23.602 119.829 46.385 1.00 15.50 ? 390 TYR M CZ 1 ATOM 3090 O OH . TYR A 1 390 ? 22.292 119.468 46.155 1.00 16.15 ? 390 TYR M OH 1 ATOM 3091 N N . SER A 1 391 ? 29.351 118.925 45.604 1.00 6.92 ? 391 SER M N 1 ATOM 3092 C CA . SER A 1 391 ? 29.487 117.825 44.657 1.00 6.03 ? 391 SER M CA 1 ATOM 3093 C C . SER A 1 391 ? 30.267 116.641 45.228 1.00 7.20 ? 391 SER M C 1 ATOM 3094 O O . SER A 1 391 ? 29.884 115.488 45.028 1.00 7.99 ? 391 SER M O 1 ATOM 3095 C CB . SER A 1 391 ? 30.130 118.323 43.368 1.00 8.87 ? 391 SER M CB 1 ATOM 3096 O OG . SER A 1 391 ? 29.311 119.307 42.756 1.00 10.21 ? 391 SER M OG 1 ATOM 3097 N N . VAL A 1 392 ? 31.343 116.924 45.957 1.00 6.69 ? 392 VAL M N 1 ATOM 3098 C CA . VAL A 1 392 ? 32.147 115.862 46.557 1.00 6.90 ? 392 VAL M CA 1 ATOM 3099 C C . VAL A 1 392 ? 31.348 115.080 47.597 1.00 7.88 ? 392 VAL M C 1 ATOM 3100 O O . VAL A 1 392 ? 31.333 113.845 47.579 1.00 8.08 ? 392 VAL M O 1 ATOM 3101 C CB . VAL A 1 392 ? 33.434 116.421 47.212 1.00 7.43 ? 392 VAL M CB 1 ATOM 3102 C CG1 . VAL A 1 392 ? 34.082 115.367 48.111 1.00 8.74 ? 392 VAL M CG1 1 ATOM 3103 C CG2 . VAL A 1 392 ? 34.416 116.847 46.130 1.00 9.12 ? 392 VAL M CG2 1 ATOM 3104 N N . MET A 1 393 ? 30.678 115.796 48.497 1.00 8.15 ? 393 MET M N 1 ATOM 3105 C CA . MET A 1 393 ? 29.892 115.143 49.543 1.00 9.50 ? 393 MET M CA 1 ATOM 3106 C C . MET A 1 393 ? 28.761 114.306 48.954 1.00 9.76 ? 393 MET M C 1 ATOM 3107 O O . MET A 1 393 ? 28.515 113.187 49.399 1.00 8.87 ? 393 MET M O 1 ATOM 3108 C CB . MET A 1 393 ? 29.328 116.168 50.527 1.00 9.02 ? 393 MET M CB 1 ATOM 3109 C CG . MET A 1 393 ? 30.387 116.949 51.294 1.00 8.96 ? 393 MET M CG 1 ATOM 3110 S SD . MET A 1 393 ? 31.592 115.885 52.124 1.00 12.71 ? 393 MET M SD 1 ATOM 3111 C CE . MET A 1 393 ? 33.105 116.808 51.793 1.00 17.63 ? 393 MET M CE 1 ATOM 3112 N N . ASP A 1 394 ? 28.082 114.857 47.952 1.00 9.46 ? 394 ASP M N 1 ATOM 3113 C CA . ASP A 1 394 ? 26.985 114.161 47.280 1.00 10.72 ? 394 ASP M CA 1 ATOM 3114 C C . ASP A 1 394 ? 27.514 112.878 46.633 1.00 9.43 ? 394 ASP M C 1 ATOM 3115 O O . ASP A 1 394 ? 26.889 111.816 46.711 1.00 10.20 ? 394 ASP M O 1 ATOM 3116 C CB . ASP A 1 394 ? 26.377 115.076 46.209 1.00 9.77 ? 394 ASP M CB 1 ATOM 3117 C CG . ASP A 1 394 ? 25.317 114.379 45.367 1.00 16.92 ? 394 ASP M CG 1 ATOM 3118 O OD1 . ASP A 1 394 ? 24.323 113.890 45.938 1.00 16.20 ? 394 ASP M OD1 1 ATOM 3119 O OD2 . ASP A 1 394 ? 25.488 114.315 44.131 1.00 20.62 ? 394 ASP M OD2 1 ATOM 3120 N N . TYR A 1 395 ? 28.678 112.992 46.003 1.00 8.01 ? 395 TYR M N 1 ATOM 3121 C CA . TYR A 1 395 ? 29.311 111.861 45.343 1.00 8.12 ? 395 TYR M CA 1 ATOM 3122 C C . TYR A 1 395 ? 29.667 110.767 46.343 1.00 8.39 ? 395 TYR M C 1 ATOM 3123 O O . TYR A 1 395 ? 29.403 109.591 46.102 1.00 10.26 ? 395 TYR M O 1 ATOM 3124 C CB . TYR A 1 395 ? 30.568 112.328 44.611 1.00 7.99 ? 395 TYR M CB 1 ATOM 3125 C CG . TYR A 1 395 ? 31.198 111.276 43.735 1.00 8.83 ? 395 TYR M CG 1 ATOM 3126 C CD1 . TYR A 1 395 ? 30.585 110.877 42.550 1.00 10.32 ? 395 TYR M CD1 1 ATOM 3127 C CD2 . TYR A 1 395 ? 32.434 110.715 44.061 1.00 8.22 ? 395 TYR M CD2 1 ATOM 3128 C CE1 . TYR A 1 395 ? 31.185 109.956 41.708 1.00 13.49 ? 395 TYR M CE1 1 ATOM 3129 C CE2 . TYR A 1 395 ? 33.045 109.785 43.222 1.00 10.25 ? 395 TYR M CE2 1 ATOM 3130 C CZ . TYR A 1 395 ? 32.412 109.415 42.047 1.00 11.62 ? 395 TYR M CZ 1 ATOM 3131 O OH . TYR A 1 395 ? 33.002 108.512 41.201 1.00 14.68 ? 395 TYR M OH 1 ATOM 3132 N N . PHE A 1 396 ? 30.267 111.151 47.465 1.00 7.49 ? 396 PHE M N 1 ATOM 3133 C CA . PHE A 1 396 ? 30.634 110.169 48.477 1.00 7.49 ? 396 PHE M CA 1 ATOM 3134 C C . PHE A 1 396 ? 29.428 109.447 49.058 1.00 9.09 ? 396 PHE M C 1 ATOM 3135 O O . PHE A 1 396 ? 29.467 108.234 49.241 1.00 9.86 ? 396 PHE M O 1 ATOM 3136 C CB . PHE A 1 396 ? 31.487 110.802 49.577 1.00 7.34 ? 396 PHE M CB 1 ATOM 3137 C CG . PHE A 1 396 ? 32.961 110.745 49.291 1.00 8.81 ? 396 PHE M CG 1 ATOM 3138 C CD1 . PHE A 1 396 ? 33.535 111.601 48.358 1.00 8.61 ? 396 PHE M CD1 1 ATOM 3139 C CD2 . PHE A 1 396 ? 33.766 109.800 49.915 1.00 8.39 ? 396 PHE M CD2 1 ATOM 3140 C CE1 . PHE A 1 396 ? 34.895 111.523 48.062 1.00 10.21 ? 396 PHE M CE1 1 ATOM 3141 C CE2 . PHE A 1 396 ? 35.126 109.715 49.626 1.00 8.45 ? 396 PHE M CE2 1 ATOM 3142 C CZ . PHE A 1 396 ? 35.690 110.575 48.692 1.00 10.03 ? 396 PHE M CZ 1 ATOM 3143 N N . LYS A 1 397 ? 28.342 110.173 49.307 1.00 9.67 ? 397 LYS M N 1 ATOM 3144 C CA . LYS A 1 397 ? 27.153 109.525 49.855 1.00 10.31 ? 397 LYS M CA 1 ATOM 3145 C C . LYS A 1 397 ? 26.546 108.532 48.872 1.00 11.37 ? 397 LYS M C 1 ATOM 3146 O O . LYS A 1 397 ? 26.247 107.397 49.234 1.00 13.28 ? 397 LYS M O 1 ATOM 3147 C CB . LYS A 1 397 ? 26.086 110.547 50.250 1.00 12.00 ? 397 LYS M CB 1 ATOM 3148 C CG . LYS A 1 397 ? 24.777 109.889 50.708 1.00 14.24 ? 397 LYS M CG 1 ATOM 3149 C CD . LYS A 1 397 ? 23.735 110.906 51.112 1.00 17.43 ? 397 LYS M CD 1 ATOM 3150 C CE . LYS A 1 397 ? 22.431 110.224 51.505 1.00 17.77 ? 397 LYS M CE 1 ATOM 3151 N NZ . LYS A 1 397 ? 21.779 109.567 50.340 1.00 21.79 ? 397 LYS M NZ 1 ATOM 3152 N N . ASN A 1 398 ? 26.398 108.953 47.622 1.00 11.79 ? 398 ASN M N 1 ATOM 3153 C CA . ASN A 1 398 ? 25.776 108.106 46.608 1.00 14.95 ? 398 ASN M CA 1 ATOM 3154 C C . ASN A 1 398 ? 26.642 107.034 45.964 1.00 15.30 ? 398 ASN M C 1 ATOM 3155 O O . ASN A 1 398 ? 26.135 105.990 45.556 1.00 15.51 ? 398 ASN M O 1 ATOM 3156 C CB . ASN A 1 398 ? 25.122 108.979 45.537 1.00 19.95 ? 398 ASN M CB 1 ATOM 3157 C CG . ASN A 1 398 ? 23.987 109.815 46.090 1.00 21.06 ? 398 ASN M CG 1 ATOM 3158 O OD1 . ASN A 1 398 ? 23.121 109.310 46.807 1.00 27.06 ? 398 ASN M OD1 1 ATOM 3159 N ND2 . ASN A 1 398 ? 23.988 111.098 45.768 1.00 29.84 ? 398 ASN M ND2 1 ATOM 3160 N N . LYS A 1 399 ? 27.946 107.276 45.891 1.00 12.67 ? 399 LYS M N 1 ATOM 3161 C CA . LYS A 1 399 ? 28.864 106.327 45.274 1.00 12.62 ? 399 LYS M CA 1 ATOM 3162 C C . LYS A 1 399 ? 29.547 105.424 46.294 1.00 12.48 ? 399 LYS M C 1 ATOM 3163 O O . LYS A 1 399 ? 29.809 104.251 46.019 1.00 11.75 ? 399 LYS M O 1 ATOM 3164 C CB . LYS A 1 399 ? 29.928 107.097 44.479 1.00 15.49 ? 399 LYS M CB 1 ATOM 3165 C CG . LYS A 1 399 ? 31.063 106.267 43.896 1.00 19.24 ? 399 LYS M CG 1 ATOM 3166 C CD . LYS A 1 399 ? 30.660 105.550 42.627 1.00 25.74 ? 399 LYS M CD 1 ATOM 3167 C CE . LYS A 1 399 ? 31.868 104.894 41.975 1.00 26.00 ? 399 LYS M CE 1 ATOM 3168 N NZ . LYS A 1 399 ? 31.504 104.254 40.684 1.00 31.27 ? 399 LYS M NZ 1 ATOM 3169 N N . TYR A 1 400 ? 29.806 105.966 47.480 1.00 11.35 ? 400 TYR M N 1 ATOM 3170 C CA . TYR A 1 400 ? 30.515 105.217 48.505 1.00 10.62 ? 400 TYR M CA 1 ATOM 3171 C C . TYR A 1 400 ? 29.769 104.814 49.764 1.00 11.87 ? 400 TYR M C 1 ATOM 3172 O O . TYR A 1 400 ? 30.274 104.942 50.882 1.00 12.06 ? 400 TYR M O 1 ATOM 3173 C CB . TYR A 1 400 ? 31.841 105.909 48.825 1.00 9.71 ? 400 TYR M CB 1 ATOM 3174 C CG . TYR A 1 400 ? 32.757 105.956 47.621 1.00 9.81 ? 400 TYR M CG 1 ATOM 3175 C CD1 . TYR A 1 400 ? 33.106 104.785 46.944 1.00 9.20 ? 400 TYR M CD1 1 ATOM 3176 C CD2 . TYR A 1 400 ? 33.248 107.167 47.137 1.00 11.37 ? 400 TYR M CD2 1 ATOM 3177 C CE1 . TYR A 1 400 ? 33.920 104.821 45.814 1.00 12.80 ? 400 TYR M CE1 1 ATOM 3178 C CE2 . TYR A 1 400 ? 34.064 107.214 46.009 1.00 12.32 ? 400 TYR M CE2 1 ATOM 3179 C CZ . TYR A 1 400 ? 34.395 106.039 45.356 1.00 11.48 ? 400 TYR M CZ 1 ATOM 3180 O OH . TYR A 1 400 ? 35.217 106.082 44.256 1.00 14.72 ? 400 TYR M OH 1 ATOM 3181 N N . TYR A 1 401 ? 28.544 104.348 49.555 1.00 11.63 ? 401 TYR M N 1 ATOM 3182 C CA . TYR A 1 401 ? 27.701 103.820 50.618 1.00 13.33 ? 401 TYR M CA 1 ATOM 3183 C C . TYR A 1 401 ? 27.352 104.678 51.830 1.00 11.40 ? 401 TYR M C 1 ATOM 3184 O O . TYR A 1 401 ? 27.445 104.209 52.966 1.00 11.63 ? 401 TYR M O 1 ATOM 3185 C CB . TYR A 1 401 ? 28.266 102.469 51.065 1.00 15.23 ? 401 TYR M CB 1 ATOM 3186 C CG . TYR A 1 401 ? 28.461 101.512 49.909 1.00 16.52 ? 401 TYR M CG 1 ATOM 3187 C CD1 . TYR A 1 401 ? 27.407 100.722 49.451 1.00 18.53 ? 401 TYR M CD1 1 ATOM 3188 C CD2 . TYR A 1 401 ? 29.685 101.427 49.246 1.00 16.84 ? 401 TYR M CD2 1 ATOM 3189 C CE1 . TYR A 1 401 ? 27.565 99.876 48.360 1.00 22.07 ? 401 TYR M CE1 1 ATOM 3190 C CE2 . TYR A 1 401 ? 29.854 100.581 48.151 1.00 18.51 ? 401 TYR M CE2 1 ATOM 3191 C CZ . TYR A 1 401 ? 28.787 99.810 47.715 1.00 22.10 ? 401 TYR M CZ 1 ATOM 3192 O OH . TYR A 1 401 ? 28.938 98.975 46.632 1.00 24.97 ? 401 TYR M OH 1 ATOM 3193 N N . ASN A 1 402 ? 26.990 105.937 51.586 1.00 10.94 ? 402 ASN M N 1 ATOM 3194 C CA . ASN A 1 402 ? 26.543 106.842 52.646 1.00 10.12 ? 402 ASN M CA 1 ATOM 3195 C C . ASN A 1 402 ? 27.422 106.799 53.903 1.00 8.74 ? 402 ASN M C 1 ATOM 3196 O O . ASN A 1 402 ? 26.969 106.433 54.988 1.00 10.67 ? 402 ASN M O 1 ATOM 3197 C CB . ASN A 1 402 ? 25.087 106.464 52.980 1.00 11.05 ? 402 ASN M CB 1 ATOM 3198 C CG . ASN A 1 402 ? 24.457 107.357 54.024 1.00 13.89 ? 402 ASN M CG 1 ATOM 3199 O OD1 . ASN A 1 402 ? 24.689 108.562 54.055 1.00 13.27 ? 402 ASN M OD1 1 ATOM 3200 N ND2 . ASN A 1 402 ? 23.629 106.762 54.883 1.00 15.58 ? 402 ASN M ND2 1 ATOM 3201 N N . PRO A 1 403 ? 28.690 107.205 53.775 1.00 8.87 ? 403 PRO M N 1 ATOM 3202 C CA . PRO A 1 403 ? 29.592 107.187 54.925 1.00 9.86 ? 403 PRO M CA 1 ATOM 3203 C C . PRO A 1 403 ? 29.422 108.352 55.887 1.00 9.33 ? 403 PRO M C 1 ATOM 3204 O O . PRO A 1 403 ? 28.844 109.387 55.538 1.00 9.67 ? 403 PRO M O 1 ATOM 3205 C CB . PRO A 1 403 ? 30.964 107.249 54.262 1.00 10.68 ? 403 PRO M CB 1 ATOM 3206 C CG . PRO A 1 403 ? 30.709 108.171 53.101 1.00 10.82 ? 403 PRO M CG 1 ATOM 3207 C CD . PRO A 1 403 ? 29.387 107.663 52.558 1.00 9.79 ? 403 PRO M CD 1 ATOM 3208 N N . LEU A 1 404 ? 29.888 108.145 57.116 1.00 9.22 ? 404 LEU M N 1 ATOM 3209 C CA . LEU A 1 404 ? 29.892 109.196 58.125 1.00 7.78 ? 404 LEU M CA 1 ATOM 3210 C C . LEU A 1 404 ? 31.120 110.006 57.709 1.00 9.04 ? 404 LEU M C 1 ATOM 3211 O O . LEU A 1 404 ? 32.198 109.444 57.494 1.00 9.36 ? 404 LEU M O 1 ATOM 3212 C CB . LEU A 1 404 ? 30.100 108.605 59.521 1.00 9.37 ? 404 LEU M CB 1 ATOM 3213 C CG . LEU A 1 404 ? 30.491 109.580 60.635 1.00 10.42 ? 404 LEU M CG 1 ATOM 3214 C CD1 . LEU A 1 404 ? 29.460 110.684 60.778 1.00 10.86 ? 404 LEU M CD1 1 ATOM 3215 C CD2 . LEU A 1 404 ? 30.640 108.819 61.944 1.00 10.36 ? 404 LEU M CD2 1 ATOM 3216 N N . ILE A 1 405 ? 30.953 111.316 57.592 1.00 6.65 ? 405 ILE M N 1 ATOM 3217 C CA . ILE A 1 405 ? 32.029 112.187 57.144 1.00 7.10 ? 405 ILE M CA 1 ATOM 3218 C C . ILE A 1 405 ? 32.317 113.349 58.071 1.00 7.55 ? 405 ILE M C 1 ATOM 3219 O O . ILE A 1 405 ? 31.415 113.917 58.679 1.00 8.65 ? 405 ILE M O 1 ATOM 3220 C CB . ILE A 1 405 ? 31.665 112.786 55.756 1.00 8.43 ? 405 ILE M CB 1 ATOM 3221 C CG1 . ILE A 1 405 ? 31.618 111.684 54.698 1.00 8.07 ? 405 ILE M CG1 1 ATOM 3222 C CG2 . ILE A 1 405 ? 32.636 113.904 55.354 1.00 8.72 ? 405 ILE M CG2 1 ATOM 3223 C CD1 . ILE A 1 405 ? 30.896 112.097 53.433 1.00 9.77 ? 405 ILE M CD1 1 ATOM 3224 N N . TYR A 1 406 ? 33.600 113.678 58.171 1.00 8.74 ? 406 TYR M N 1 ATOM 3225 C CA . TYR A 1 406 ? 34.064 114.835 58.918 1.00 8.29 ? 406 TYR M CA 1 ATOM 3226 C C . TYR A 1 406 ? 34.973 115.551 57.937 1.00 8.26 ? 406 TYR M C 1 ATOM 3227 O O . TYR A 1 406 ? 35.843 114.923 57.328 1.00 7.62 ? 406 TYR M O 1 ATOM 3228 C CB . TYR A 1 406 ? 34.873 114.439 60.153 1.00 10.24 ? 406 TYR M CB 1 ATOM 3229 C CG . TYR A 1 406 ? 34.014 113.947 61.284 1.00 10.79 ? 406 TYR M CG 1 ATOM 3230 C CD1 . TYR A 1 406 ? 33.750 112.589 61.439 1.00 12.96 ? 406 TYR M CD1 1 ATOM 3231 C CD2 . TYR A 1 406 ? 33.431 114.845 62.180 1.00 11.05 ? 406 TYR M CD2 1 ATOM 3232 C CE1 . TYR A 1 406 ? 32.916 112.134 62.454 1.00 13.14 ? 406 TYR M CE1 1 ATOM 3233 C CE2 . TYR A 1 406 ? 32.599 114.398 63.199 1.00 14.76 ? 406 TYR M CE2 1 ATOM 3234 C CZ . TYR A 1 406 ? 32.349 113.043 63.325 1.00 15.41 ? 406 TYR M CZ 1 ATOM 3235 O OH . TYR A 1 406 ? 31.511 112.597 64.317 1.00 21.59 ? 406 TYR M OH 1 ATOM 3236 N N . VAL A 1 407 ? 34.704 116.829 57.690 1.00 7.36 ? 407 VAL M N 1 ATOM 3237 C CA . VAL A 1 407 ? 35.567 117.598 56.794 1.00 6.36 ? 407 VAL M CA 1 ATOM 3238 C C . VAL A 1 407 ? 36.776 117.922 57.664 1.00 8.70 ? 407 VAL M C 1 ATOM 3239 O O . VAL A 1 407 ? 36.693 118.722 58.595 1.00 9.54 ? 407 VAL M O 1 ATOM 3240 C CB . VAL A 1 407 ? 34.878 118.868 56.279 1.00 7.88 ? 407 VAL M CB 1 ATOM 3241 C CG1 . VAL A 1 407 ? 35.863 119.706 55.449 1.00 7.88 ? 407 VAL M CG1 1 ATOM 3242 C CG2 . VAL A 1 407 ? 33.682 118.480 55.424 1.00 8.27 ? 407 VAL M CG2 1 ATOM 3243 N N . THR A 1 408 ? 37.881 117.240 57.383 1.00 8.25 ? 408 THR M N 1 ATOM 3244 C CA . THR A 1 408 ? 39.094 117.372 58.179 1.00 8.17 ? 408 THR M CA 1 ATOM 3245 C C . THR A 1 408 ? 40.078 118.473 57.801 1.00 7.89 ? 408 THR M C 1 ATOM 3246 O O . THR A 1 408 ? 41.006 118.749 58.557 1.00 8.10 ? 408 THR M O 1 ATOM 3247 C CB . THR A 1 408 ? 39.787 116.006 58.301 1.00 8.23 ? 408 THR M CB 1 ATOM 3248 O OG1 . THR A 1 408 ? 39.732 115.340 57.037 1.00 7.45 ? 408 THR M OG1 1 ATOM 3249 C CG2 . THR A 1 408 ? 39.053 115.137 59.332 1.00 8.54 ? 408 THR M CG2 1 ATOM 3250 N N . GLU A 1 409 ? 39.864 119.090 56.640 1.00 6.81 ? 409 GLU M N 1 ATOM 3251 C CA . GLU A 1 409 ? 40.672 120.213 56.158 1.00 7.70 ? 409 GLU M CA 1 ATOM 3252 C C . GLU A 1 409 ? 39.914 120.962 55.074 1.00 6.31 ? 409 GLU M C 1 ATOM 3253 O O . GLU A 1 409 ? 39.314 120.354 54.195 1.00 7.43 ? 409 GLU M O 1 ATOM 3254 C CB . GLU A 1 409 ? 42.015 119.765 55.564 1.00 9.54 ? 409 GLU M CB 1 ATOM 3255 C CG . GLU A 1 409 ? 43.081 119.386 56.577 1.00 10.46 ? 409 GLU M CG 1 ATOM 3256 C CD . GLU A 1 409 ? 44.411 119.072 55.927 1.00 12.46 ? 409 GLU M CD 1 ATOM 3257 O OE1 . GLU A 1 409 ? 44.737 119.707 54.906 1.00 12.24 ? 409 GLU M OE1 1 ATOM 3258 O OE2 . GLU A 1 409 ? 45.138 118.196 56.435 1.00 11.82 ? 409 GLU M OE2 1 ATOM 3259 N N . ASN A 1 410 ? 39.971 122.285 55.144 1.00 7.32 ? 410 ASN M N 1 ATOM 3260 C CA . ASN A 1 410 ? 39.354 123.171 54.157 1.00 6.32 ? 410 ASN M CA 1 ATOM 3261 C C . ASN A 1 410 ? 39.902 124.545 54.503 1.00 6.40 ? 410 ASN M C 1 ATOM 3262 O O . ASN A 1 410 ? 39.677 125.038 55.604 1.00 9.00 ? 410 ASN M O 1 ATOM 3263 C CB . ASN A 1 410 ? 37.822 123.157 54.263 1.00 7.98 ? 410 ASN M CB 1 ATOM 3264 C CG . ASN A 1 410 ? 37.155 124.084 53.248 1.00 9.26 ? 410 ASN M CG 1 ATOM 3265 O OD1 . ASN A 1 410 ? 36.438 125.012 53.618 1.00 10.65 ? 410 ASN M OD1 1 ATOM 3266 N ND2 . ASN A 1 410 ? 37.396 123.836 51.962 1.00 8.51 ? 410 ASN M ND2 1 ATOM 3267 N N . GLY A 1 411 ? 40.653 125.145 53.584 1.00 6.12 ? 411 GLY M N 1 ATOM 3268 C CA . GLY A 1 411 ? 41.230 126.450 53.866 1.00 7.22 ? 411 GLY M CA 1 ATOM 3269 C C . GLY A 1 411 ? 41.873 127.064 52.641 1.00 7.86 ? 411 GLY M C 1 ATOM 3270 O O . GLY A 1 411 ? 41.901 126.452 51.576 1.00 7.79 ? 411 GLY M O 1 ATOM 3271 N N . ILE A 1 412 ? 42.449 128.248 52.812 1.00 6.88 ? 412 ILE M N 1 ATOM 3272 C CA . ILE A 1 412 ? 43.072 128.960 51.699 1.00 6.99 ? 412 ILE M CA 1 ATOM 3273 C C . ILE A 1 412 ? 44.283 129.737 52.204 1.00 8.29 ? 412 ILE M C 1 ATOM 3274 O O . ILE A 1 412 ? 44.344 130.132 53.368 1.00 10.00 ? 412 ILE M O 1 ATOM 3275 C CB . ILE A 1 412 ? 42.047 129.930 51.040 1.00 7.38 ? 412 ILE M CB 1 ATOM 3276 C CG1 . ILE A 1 412 ? 42.640 130.595 49.800 1.00 6.34 ? 412 ILE M CG1 1 ATOM 3277 C CG2 . ILE A 1 412 ? 41.584 130.980 52.042 1.00 9.25 ? 412 ILE M CG2 1 ATOM 3278 C CD1 . ILE A 1 412 ? 41.618 131.395 49.005 1.00 8.24 ? 412 ILE M CD1 1 ATOM 3279 N N . SER A 1 413 ? 45.267 129.922 51.335 1.00 11.54 ? 413 SER M N 1 ATOM 3280 C CA . SER A 1 413 ? 46.461 130.649 51.727 1.00 12.56 ? 413 SER M CA 1 ATOM 3281 C C . SER A 1 413 ? 46.428 132.102 51.288 1.00 12.10 ? 413 SER M C 1 ATOM 3282 O O . SER A 1 413 ? 45.625 132.501 50.442 1.00 12.39 ? 413 SER M O 1 ATOM 3283 C CB . SER A 1 413 ? 47.710 129.994 51.138 1.00 16.02 ? 413 SER M CB 1 ATOM 3284 O OG . SER A 1 413 ? 47.818 130.249 49.746 1.00 18.43 ? 413 SER M OG 1 ATOM 3285 N N . THR A 1 414 ? 47.281 132.888 51.927 1.00 12.65 ? 414 THR M N 1 ATOM 3286 C CA . THR A 1 414 ? 47.465 134.296 51.605 1.00 13.28 ? 414 THR M CA 1 ATOM 3287 C C . THR A 1 414 ? 48.984 134.415 51.501 1.00 15.22 ? 414 THR M C 1 ATOM 3288 O O . THR A 1 414 ? 49.715 133.646 52.131 1.00 13.13 ? 414 THR M O 1 ATOM 3289 C CB . THR A 1 414 ? 46.914 135.246 52.698 1.00 17.12 ? 414 THR M CB 1 ATOM 3290 O OG1 . THR A 1 414 ? 47.370 134.825 53.988 1.00 18.91 ? 414 THR M OG1 1 ATOM 3291 C CG2 . THR A 1 414 ? 45.394 135.276 52.671 1.00 18.35 ? 414 THR M CG2 1 ATOM 3292 N N . PRO A 1 415 ? 49.478 135.331 50.657 1.00 16.27 ? 415 PRO M N 1 ATOM 3293 C CA . PRO A 1 415 ? 50.916 135.537 50.461 1.00 20.95 ? 415 PRO M CA 1 ATOM 3294 C C . PRO A 1 415 ? 51.727 135.790 51.729 1.00 20.98 ? 415 PRO M C 1 ATOM 3295 O O . PRO A 1 415 ? 51.258 136.432 52.667 1.00 24.72 ? 415 PRO M O 1 ATOM 3296 C CB . PRO A 1 415 ? 50.958 136.749 49.530 1.00 21.56 ? 415 PRO M CB 1 ATOM 3297 C CG . PRO A 1 415 ? 49.715 136.593 48.726 1.00 19.67 ? 415 PRO M CG 1 ATOM 3298 C CD . PRO A 1 415 ? 48.701 136.228 49.783 1.00 19.24 ? 415 PRO M CD 1 ATOM 3299 N N . GLY A 1 416 ? 52.945 135.257 51.747 1.00 24.34 ? 416 GLY M N 1 ATOM 3300 C CA . GLY A 1 416 ? 53.830 135.448 52.880 1.00 29.09 ? 416 GLY M CA 1 ATOM 3301 C C . GLY A 1 416 ? 54.504 136.808 52.813 1.00 31.57 ? 416 GLY M C 1 ATOM 3302 O O . GLY A 1 416 ? 55.071 137.270 53.800 1.00 35.14 ? 416 GLY M O 1 ATOM 3303 N N . ASP A 1 417 ? 54.432 137.450 51.646 1.00 35.65 ? 417 ASP M N 1 ATOM 3304 C CA . ASP A 1 417 ? 55.028 138.769 51.433 1.00 37.88 ? 417 ASP M CA 1 ATOM 3305 C C . ASP A 1 417 ? 54.274 139.882 52.154 1.00 38.80 ? 417 ASP M C 1 ATOM 3306 O O . ASP A 1 417 ? 54.846 140.932 52.452 1.00 37.76 ? 417 ASP M O 1 ATOM 3307 C CB . ASP A 1 417 ? 55.091 139.103 49.938 1.00 41.03 ? 417 ASP M CB 1 ATOM 3308 C CG . ASP A 1 417 ? 56.143 138.301 49.197 1.00 44.54 ? 417 ASP M CG 1 ATOM 3309 O OD1 . ASP A 1 417 ? 57.240 138.078 49.755 1.00 48.15 ? 417 ASP M OD1 1 ATOM 3310 O OD2 . ASP A 1 417 ? 55.876 137.905 48.042 1.00 47.83 ? 417 ASP M OD2 1 ATOM 3311 N N . GLU A 1 418 ? 52.988 139.658 52.411 1.00 37.73 ? 418 GLU M N 1 ATOM 3312 C CA . GLU A 1 418 ? 52.158 140.650 53.092 1.00 37.43 ? 418 GLU M CA 1 ATOM 3313 C C . GLU A 1 418 ? 52.683 140.950 54.491 1.00 36.84 ? 418 GLU M C 1 ATOM 3314 O O . GLU A 1 418 ? 53.226 140.068 55.158 1.00 38.57 ? 418 GLU M O 1 ATOM 3315 C CB . GLU A 1 418 ? 50.711 140.162 53.194 1.00 36.55 ? 418 GLU M CB 1 ATOM 3316 C CG . GLU A 1 418 ? 50.013 139.930 51.862 1.00 35.97 ? 418 GLU M CG 1 ATOM 3317 C CD . GLU A 1 418 ? 48.550 139.546 52.026 1.00 36.50 ? 418 GLU M CD 1 ATOM 3318 O OE1 . GLU A 1 418 ? 48.217 138.836 53.001 1.00 32.41 ? 418 GLU M OE1 1 ATOM 3319 O OE2 . GLU A 1 418 ? 47.727 139.959 51.180 1.00 36.95 ? 418 GLU M OE2 1 ATOM 3320 N N . ASN A 1 419 ? 52.539 142.201 54.922 1.00 37.64 ? 419 ASN M N 1 ATOM 3321 C CA . ASN A 1 419 ? 52.979 142.605 56.254 1.00 37.30 ? 419 ASN M CA 1 ATOM 3322 C C . ASN A 1 419 ? 51.950 142.149 57.289 1.00 37.45 ? 419 ASN M C 1 ATOM 3323 O O . ASN A 1 419 ? 50.939 141.540 56.934 1.00 35.23 ? 419 ASN M O 1 ATOM 3324 C CB . ASN A 1 419 ? 53.189 144.125 56.326 1.00 40.07 ? 419 ASN M CB 1 ATOM 3325 C CG . ASN A 1 419 ? 51.953 144.913 55.926 1.00 41.74 ? 419 ASN M CG 1 ATOM 3326 O OD1 . ASN A 1 419 ? 50.922 144.865 56.600 1.00 41.92 ? 419 ASN M OD1 1 ATOM 3327 N ND2 . ASN A 1 419 ? 52.058 145.658 54.831 1.00 43.73 ? 419 ASN M ND2 1 ATOM 3328 N N . ARG A 1 420 ? 52.200 142.458 58.559 1.00 36.58 ? 420 ARG M N 1 ATOM 3329 C CA . ARG A 1 420 ? 51.296 142.064 59.636 1.00 37.26 ? 420 ARG M CA 1 ATOM 3330 C C . ARG A 1 420 ? 49.855 142.527 59.429 1.00 37.16 ? 420 ARG M C 1 ATOM 3331 O O . ARG A 1 420 ? 48.930 141.718 59.489 1.00 34.88 ? 420 ARG M O 1 ATOM 3332 C CB . ARG A 1 420 ? 51.806 142.568 60.987 1.00 38.56 ? 420 ARG M CB 1 ATOM 3333 C CG . ARG A 1 420 ? 51.004 142.042 62.165 1.00 40.68 ? 420 ARG M CG 1 ATOM 3334 C CD . ARG A 1 420 ? 51.528 142.561 63.492 1.00 44.32 ? 420 ARG M CD 1 ATOM 3335 N NE . ARG A 1 420 ? 50.868 141.912 64.624 1.00 46.19 ? 420 ARG M NE 1 ATOM 3336 C CZ . ARG A 1 420 ? 49.628 142.175 65.031 1.00 47.52 ? 420 ARG M CZ 1 ATOM 3337 N NH1 . ARG A 1 420 ? 48.892 143.083 64.403 1.00 48.19 ? 420 ARG M NH1 1 ATOM 3338 N NH2 . ARG A 1 420 ? 49.121 141.520 66.067 1.00 48.87 ? 420 ARG M NH2 1 ATOM 3339 N N . ASN A 1 421 ? 49.671 143.823 59.185 1.00 35.06 ? 421 ASN M N 1 ATOM 3340 C CA . ASN A 1 421 ? 48.337 144.383 58.976 1.00 34.60 ? 421 ASN M CA 1 ATOM 3341 C C . ASN A 1 421 ? 47.595 143.741 57.810 1.00 31.80 ? 421 ASN M C 1 ATOM 3342 O O . ASN A 1 421 ? 46.426 143.383 57.941 1.00 32.87 ? 421 ASN M O 1 ATOM 3343 C CB . ASN A 1 421 ? 48.412 145.901 58.781 1.00 36.93 ? 421 ASN M CB 1 ATOM 3344 C CG . ASN A 1 421 ? 48.831 146.631 60.042 1.00 39.25 ? 421 ASN M CG 1 ATOM 3345 O OD1 . ASN A 1 421 ? 48.524 146.201 61.156 1.00 40.53 ? 421 ASN M OD1 1 ATOM 3346 N ND2 . ASN A 1 421 ? 49.535 147.747 59.874 1.00 41.64 ? 421 ASN M ND2 1 ATOM 3347 N N . GLN A 1 422 ? 48.278 143.588 56.677 1.00 29.96 ? 422 GLN M N 1 ATOM 3348 C CA . GLN A 1 422 ? 47.678 142.979 55.493 1.00 27.40 ? 422 GLN M CA 1 ATOM 3349 C C . GLN A 1 422 ? 47.287 141.529 55.769 1.00 24.38 ? 422 GLN M C 1 ATOM 3350 O O . GLN A 1 422 ? 46.193 141.094 55.405 1.00 22.57 ? 422 GLN M O 1 ATOM 3351 C CB . GLN A 1 422 ? 48.644 143.037 54.306 1.00 29.82 ? 422 GLN M CB 1 ATOM 3352 C CG . GLN A 1 422 ? 48.975 144.446 53.832 1.00 34.21 ? 422 GLN M CG 1 ATOM 3353 C CD . GLN A 1 422 ? 49.930 144.459 52.651 1.00 35.81 ? 422 GLN M CD 1 ATOM 3354 O OE1 . GLN A 1 422 ? 50.891 143.688 52.601 1.00 36.84 ? 422 GLN M OE1 1 ATOM 3355 N NE2 . GLN A 1 422 ? 49.673 145.342 51.694 1.00 38.71 ? 422 GLN M NE2 1 ATOM 3356 N N . SER A 1 423 ? 48.178 140.801 56.439 1.00 23.12 ? 423 SER M N 1 ATOM 3357 C CA . SER A 1 423 ? 47.944 139.398 56.778 1.00 22.07 ? 423 SER M CA 1 ATOM 3358 C C . SER A 1 423 ? 46.755 139.226 57.720 1.00 21.68 ? 423 SER M C 1 ATOM 3359 O O . SER A 1 423 ? 46.021 138.240 57.626 1.00 18.13 ? 423 SER M O 1 ATOM 3360 C CB . SER A 1 423 ? 49.194 138.789 57.416 1.00 25.85 ? 423 SER M CB 1 ATOM 3361 O OG . SER A 1 423 ? 50.303 138.866 56.538 1.00 29.95 ? 423 SER M OG 1 ATOM 3362 N N . MET A 1 424 ? 46.579 140.181 58.632 1.00 18.72 ? 424 MET M N 1 ATOM 3363 C CA . MET A 1 424 ? 45.478 140.150 59.593 1.00 20.24 ? 424 MET M CA 1 ATOM 3364 C C . MET A 1 424 ? 44.133 140.408 58.918 1.00 17.86 ? 424 MET M C 1 ATOM 3365 O O . MET A 1 424 ? 43.108 139.887 59.350 1.00 15.87 ? 424 MET M O 1 ATOM 3366 C CB . MET A 1 424 ? 45.688 141.201 60.686 1.00 23.53 ? 424 MET M CB 1 ATOM 3367 C CG . MET A 1 424 ? 46.884 140.958 61.584 1.00 30.86 ? 424 MET M CG 1 ATOM 3368 S SD . MET A 1 424 ? 46.690 139.496 62.603 1.00 36.39 ? 424 MET M SD 1 ATOM 3369 C CE . MET A 1 424 ? 45.655 140.129 63.922 1.00 35.93 ? 424 MET M CE 1 ATOM 3370 N N . LEU A 1 425 ? 44.142 141.246 57.884 1.00 15.06 ? 425 LEU M N 1 ATOM 3371 C CA . LEU A 1 425 ? 42.926 141.590 57.148 1.00 16.74 ? 425 LEU M CA 1 ATOM 3372 C C . LEU A 1 425 ? 42.705 140.582 56.031 1.00 15.66 ? 425 LEU M C 1 ATOM 3373 O O . LEU A 1 425 ? 42.644 140.937 54.853 1.00 14.85 ? 425 LEU M O 1 ATOM 3374 C CB . LEU A 1 425 ? 43.048 143.001 56.562 1.00 16.95 ? 425 LEU M CB 1 ATOM 3375 C CG . LEU A 1 425 ? 43.236 144.130 57.580 1.00 19.18 ? 425 LEU M CG 1 ATOM 3376 C CD1 . LEU A 1 425 ? 43.418 145.452 56.843 1.00 18.92 ? 425 LEU M CD1 1 ATOM 3377 C CD2 . LEU A 1 425 ? 42.042 144.196 58.515 1.00 20.00 ? 425 LEU M CD2 1 ATOM 3378 N N . ASP A 1 426 ? 42.549 139.321 56.419 1.00 14.62 ? 426 ASP M N 1 ATOM 3379 C CA . ASP A 1 426 ? 42.366 138.240 55.461 1.00 13.63 ? 426 ASP M CA 1 ATOM 3380 C C . ASP A 1 426 ? 40.914 137.989 55.053 1.00 13.39 ? 426 ASP M C 1 ATOM 3381 O O . ASP A 1 426 ? 40.367 136.906 55.269 1.00 11.88 ? 426 ASP M O 1 ATOM 3382 C CB . ASP A 1 426 ? 43.022 136.961 55.997 1.00 13.30 ? 426 ASP M CB 1 ATOM 3383 C CG . ASP A 1 426 ? 42.419 136.489 57.314 1.00 14.92 ? 426 ASP M CG 1 ATOM 3384 O OD1 . ASP A 1 426 ? 41.732 137.269 58.006 1.00 12.47 ? 426 ASP M OD1 1 ATOM 3385 O OD2 . ASP A 1 426 ? 42.635 135.313 57.657 1.00 13.48 ? 426 ASP M OD2 1 ATOM 3386 N N . TYR A 1 427 ? 40.302 138.986 54.419 1.00 11.55 ? 427 TYR M N 1 ATOM 3387 C CA . TYR A 1 427 ? 38.919 138.860 53.977 1.00 11.80 ? 427 TYR M CA 1 ATOM 3388 C C . TYR A 1 427 ? 38.747 137.760 52.931 1.00 10.50 ? 427 TYR M C 1 ATOM 3389 O O . TYR A 1 427 ? 37.669 137.168 52.820 1.00 9.46 ? 427 TYR M O 1 ATOM 3390 C CB . TYR A 1 427 ? 38.407 140.194 53.436 1.00 12.91 ? 427 TYR M CB 1 ATOM 3391 C CG . TYR A 1 427 ? 38.407 141.291 54.476 1.00 14.16 ? 427 TYR M CG 1 ATOM 3392 C CD1 . TYR A 1 427 ? 37.427 141.338 55.466 1.00 18.56 ? 427 TYR M CD1 1 ATOM 3393 C CD2 . TYR A 1 427 ? 39.395 142.275 54.477 1.00 18.71 ? 427 TYR M CD2 1 ATOM 3394 C CE1 . TYR A 1 427 ? 37.429 142.343 56.434 1.00 19.44 ? 427 TYR M CE1 1 ATOM 3395 C CE2 . TYR A 1 427 ? 39.406 143.284 55.440 1.00 19.36 ? 427 TYR M CE2 1 ATOM 3396 C CZ . TYR A 1 427 ? 38.422 143.309 56.412 1.00 20.90 ? 427 TYR M CZ 1 ATOM 3397 O OH . TYR A 1 427 ? 38.437 144.299 57.370 1.00 24.10 ? 427 TYR M OH 1 ATOM 3398 N N . THR A 1 428 ? 39.806 137.483 52.171 1.00 11.18 ? 428 THR M N 1 ATOM 3399 C CA . THR A 1 428 ? 39.745 136.433 51.155 1.00 10.89 ? 428 THR M CA 1 ATOM 3400 C C . THR A 1 428 ? 39.541 135.077 51.824 1.00 10.37 ? 428 THR M C 1 ATOM 3401 O O . THR A 1 428 ? 38.937 134.179 51.242 1.00 11.01 ? 428 THR M O 1 ATOM 3402 C CB . THR A 1 428 ? 41.024 136.361 50.290 1.00 12.64 ? 428 THR M CB 1 ATOM 3403 O OG1 . THR A 1 428 ? 42.178 136.246 51.131 1.00 14.28 ? 428 THR M OG1 1 ATOM 3404 C CG2 . THR A 1 428 ? 41.146 137.589 49.402 1.00 14.77 ? 428 THR M CG2 1 ATOM 3405 N N . ARG A 1 429 ? 40.050 134.936 53.046 1.00 9.63 ? 429 ARG M N 1 ATOM 3406 C CA . ARG A 1 429 ? 39.907 133.688 53.787 1.00 8.57 ? 429 ARG M CA 1 ATOM 3407 C C . ARG A 1 429 ? 38.475 133.550 54.305 1.00 9.92 ? 429 ARG M C 1 ATOM 3408 O O . ARG A 1 429 ? 37.902 132.462 54.277 1.00 9.84 ? 429 ARG M O 1 ATOM 3409 C CB . ARG A 1 429 ? 40.929 133.609 54.926 1.00 9.56 ? 429 ARG M CB 1 ATOM 3410 C CG . ARG A 1 429 ? 40.886 132.304 55.715 1.00 7.58 ? 429 ARG M CG 1 ATOM 3411 C CD . ARG A 1 429 ? 42.153 132.106 56.534 1.00 8.99 ? 429 ARG M CD 1 ATOM 3412 N NE . ARG A 1 429 ? 43.316 131.852 55.688 1.00 11.28 ? 429 ARG M NE 1 ATOM 3413 C CZ . ARG A 1 429 ? 44.344 132.683 55.537 1.00 10.67 ? 429 ARG M CZ 1 ATOM 3414 N NH1 . ARG A 1 429 ? 44.372 133.848 56.175 1.00 11.88 ? 429 ARG M NH1 1 ATOM 3415 N NH2 . ARG A 1 429 ? 45.353 132.346 54.747 1.00 12.80 ? 429 ARG M NH2 1 ATOM 3416 N N . ILE A 1 430 ? 37.881 134.653 54.757 1.00 8.29 ? 430 ILE M N 1 ATOM 3417 C CA . ILE A 1 430 ? 36.498 134.607 55.226 1.00 9.05 ? 430 ILE M CA 1 ATOM 3418 C C . ILE A 1 430 ? 35.614 134.174 54.056 1.00 9.47 ? 430 ILE M C 1 ATOM 3419 O O . ILE A 1 430 ? 34.764 133.292 54.195 1.00 9.20 ? 430 ILE M O 1 ATOM 3420 C CB . ILE A 1 430 ? 36.014 135.983 55.740 1.00 8.68 ? 430 ILE M CB 1 ATOM 3421 C CG1 . ILE A 1 430 ? 36.768 136.356 57.019 1.00 10.45 ? 430 ILE M CG1 1 ATOM 3422 C CG2 . ILE A 1 430 ? 34.508 135.960 55.987 1.00 12.41 ? 430 ILE M CG2 1 ATOM 3423 C CD1 . ILE A 1 430 ? 36.425 137.735 57.571 1.00 11.64 ? 430 ILE M CD1 1 ATOM 3424 N N . ASP A 1 431 ? 35.855 134.764 52.889 1.00 10.19 ? 431 ASP M N 1 ATOM 3425 C CA . ASP A 1 431 ? 35.077 134.441 51.700 1.00 10.58 ? 431 ASP M CA 1 ATOM 3426 C C . ASP A 1 431 ? 35.190 132.977 51.319 1.00 10.58 ? 431 ASP M C 1 ATOM 3427 O O . ASP A 1 431 ? 34.190 132.328 51.011 1.00 10.05 ? 431 ASP M O 1 ATOM 3428 C CB . ASP A 1 431 ? 35.499 135.326 50.532 1.00 11.13 ? 431 ASP M CB 1 ATOM 3429 C CG . ASP A 1 431 ? 34.960 136.743 50.651 1.00 16.29 ? 431 ASP M CG 1 ATOM 3430 O OD1 . ASP A 1 431 ? 34.153 137.014 51.569 1.00 16.43 ? 431 ASP M OD1 1 ATOM 3431 O OD2 . ASP A 1 431 ? 35.333 137.580 49.808 1.00 16.05 ? 431 ASP M OD2 1 ATOM 3432 N N . TYR A 1 432 ? 36.410 132.458 51.354 1.00 8.13 ? 432 TYR M N 1 ATOM 3433 C CA . TYR A 1 432 ? 36.633 131.063 51.017 1.00 6.86 ? 432 TYR M CA 1 ATOM 3434 C C . TYR A 1 432 ? 35.918 130.145 52.006 1.00 7.51 ? 432 TYR M C 1 ATOM 3435 O O . TYR A 1 432 ? 35.155 129.268 51.608 1.00 8.15 ? 432 TYR M O 1 ATOM 3436 C CB . TYR A 1 432 ? 38.130 130.756 51.005 1.00 5.87 ? 432 TYR M CB 1 ATOM 3437 C CG . TYR A 1 432 ? 38.427 129.312 50.700 1.00 7.66 ? 432 TYR M CG 1 ATOM 3438 C CD1 . TYR A 1 432 ? 38.420 128.352 51.713 1.00 6.69 ? 432 TYR M CD1 1 ATOM 3439 C CD2 . TYR A 1 432 ? 38.675 128.892 49.396 1.00 6.59 ? 432 TYR M CD2 1 ATOM 3440 C CE1 . TYR A 1 432 ? 38.644 127.022 51.434 1.00 7.92 ? 432 TYR M CE1 1 ATOM 3441 C CE2 . TYR A 1 432 ? 38.907 127.556 49.107 1.00 7.02 ? 432 TYR M CE2 1 ATOM 3442 C CZ . TYR A 1 432 ? 38.887 126.629 50.130 1.00 9.57 ? 432 TYR M CZ 1 ATOM 3443 O OH . TYR A 1 432 ? 39.104 125.305 49.855 1.00 8.91 ? 432 TYR M OH 1 ATOM 3444 N N . LEU A 1 433 ? 36.154 130.359 53.295 1.00 7.22 ? 433 LEU M N 1 ATOM 3445 C CA . LEU A 1 433 ? 35.545 129.523 54.322 1.00 8.34 ? 433 LEU M CA 1 ATOM 3446 C C . LEU A 1 433 ? 34.023 129.573 54.339 1.00 9.56 ? 433 LEU M C 1 ATOM 3447 O O . LEU A 1 433 ? 33.379 128.528 54.369 1.00 10.17 ? 433 LEU M O 1 ATOM 3448 C CB . LEU A 1 433 ? 36.091 129.886 55.702 1.00 7.84 ? 433 LEU M CB 1 ATOM 3449 C CG . LEU A 1 433 ? 37.597 129.698 55.922 1.00 7.02 ? 433 LEU M CG 1 ATOM 3450 C CD1 . LEU A 1 433 ? 37.968 130.211 57.311 1.00 9.13 ? 433 LEU M CD1 1 ATOM 3451 C CD2 . LEU A 1 433 ? 37.992 128.236 55.753 1.00 9.92 ? 433 LEU M CD2 1 ATOM 3452 N N . CYS A 1 434 ? 33.445 130.772 54.291 1.00 9.70 ? 434 CYS M N 1 ATOM 3453 C CA . CYS A 1 434 ? 31.988 130.879 54.329 1.00 9.28 ? 434 CYS M CA 1 ATOM 3454 C C . CYS A 1 434 ? 31.294 130.330 53.096 1.00 10.13 ? 434 CYS M C 1 ATOM 3455 O O . CYS A 1 434 ? 30.230 129.724 53.210 1.00 10.03 ? 434 CYS M O 1 ATOM 3456 C CB . CYS A 1 434 ? 31.517 132.312 54.617 1.00 12.16 ? 434 CYS M CB 1 ATOM 3457 S SG . CYS A 1 434 ? 31.610 133.536 53.263 1.00 15.97 ? 434 CYS M SG 1 ATOM 3458 N N . SER A 1 435 ? 31.905 130.515 51.927 1.00 8.91 ? 435 SER M N 1 ATOM 3459 C CA . SER A 1 435 ? 31.313 130.030 50.687 1.00 8.56 ? 435 SER M CA 1 ATOM 3460 C C . SER A 1 435 ? 31.263 128.507 50.679 1.00 9.90 ? 435 SER M C 1 ATOM 3461 O O . SER A 1 435 ? 30.305 127.913 50.181 1.00 10.41 ? 435 SER M O 1 ATOM 3462 C CB . SER A 1 435 ? 32.049 130.580 49.455 1.00 9.24 ? 435 SER M CB 1 ATOM 3463 O OG . SER A 1 435 ? 33.391 130.129 49.378 1.00 10.81 ? 435 SER M OG 1 ATOM 3464 N N . HIS A 1 436 ? 32.274 127.878 51.271 1.00 7.61 ? 436 HIS M N 1 ATOM 3465 C CA . HIS A 1 436 ? 32.300 126.426 51.353 1.00 8.37 ? 436 HIS M CA 1 ATOM 3466 C C . HIS A 1 436 ? 31.345 125.923 52.426 1.00 7.77 ? 436 HIS M C 1 ATOM 3467 O O . HIS A 1 436 ? 30.670 124.911 52.237 1.00 7.77 ? 436 HIS M O 1 ATOM 3468 C CB . HIS A 1 436 ? 33.722 125.919 51.576 1.00 8.42 ? 436 HIS M CB 1 ATOM 3469 C CG . HIS A 1 436 ? 34.561 125.989 50.344 1.00 7.01 ? 436 HIS M CG 1 ATOM 3470 N ND1 . HIS A 1 436 ? 35.172 127.148 49.927 1.00 9.62 ? 436 HIS M ND1 1 ATOM 3471 C CD2 . HIS A 1 436 ? 34.827 125.058 49.392 1.00 9.15 ? 436 HIS M CD2 1 ATOM 3472 C CE1 . HIS A 1 436 ? 35.777 126.935 48.769 1.00 9.10 ? 436 HIS M CE1 1 ATOM 3473 N NE2 . HIS A 1 436 ? 35.580 125.674 48.427 1.00 8.50 ? 436 HIS M NE2 1 ATOM 3474 N N . LEU A 1 437 ? 31.258 126.651 53.536 1.00 8.27 ? 437 LEU M N 1 ATOM 3475 C CA . LEU A 1 437 ? 30.349 126.269 54.610 1.00 7.81 ? 437 LEU M CA 1 ATOM 3476 C C . LEU A 1 437 ? 28.906 126.390 54.140 1.00 9.58 ? 437 LEU M C 1 ATOM 3477 O O . LEU A 1 437 ? 28.056 125.585 54.520 1.00 9.74 ? 437 LEU M O 1 ATOM 3478 C CB . LEU A 1 437 ? 30.589 127.123 55.855 1.00 9.20 ? 437 LEU M CB 1 ATOM 3479 C CG . LEU A 1 437 ? 31.788 126.651 56.681 1.00 8.25 ? 437 LEU M CG 1 ATOM 3480 C CD1 . LEU A 1 437 ? 32.174 127.686 57.722 1.00 8.98 ? 437 LEU M CD1 1 ATOM 3481 C CD2 . LEU A 1 437 ? 31.445 125.323 57.349 1.00 9.38 ? 437 LEU M CD2 1 ATOM 3482 N N . CYS A 1 438 ? 28.634 127.378 53.289 1.00 9.26 ? 438 CYS M N 1 ATOM 3483 C CA . CYS A 1 438 ? 27.281 127.552 52.763 1.00 9.98 ? 438 CYS M CA 1 ATOM 3484 C C . CYS A 1 438 ? 26.894 126.300 51.996 1.00 10.56 ? 438 CYS M C 1 ATOM 3485 O O . CYS A 1 438 ? 25.840 125.715 52.241 1.00 10.51 ? 438 CYS M O 1 ATOM 3486 C CB . CYS A 1 438 ? 27.190 128.739 51.807 1.00 11.79 ? 438 CYS M CB 1 ATOM 3487 S SG . CYS A 1 438 ? 25.477 129.075 51.263 1.00 18.07 ? 438 CYS M SG 1 ATOM 3488 N N . PHE A 1 439 ? 27.761 125.891 51.072 1.00 8.36 ? 439 PHE M N 1 ATOM 3489 C CA . PHE A 1 439 ? 27.507 124.703 50.269 1.00 7.29 ? 439 PHE M CA 1 ATOM 3490 C C . PHE A 1 439 ? 27.486 123.416 51.076 1.00 7.80 ? 439 PHE M C 1 ATOM 3491 O O . PHE A 1 439 ? 26.785 122.470 50.714 1.00 8.68 ? 439 PHE M O 1 ATOM 3492 C CB . PHE A 1 439 ? 28.497 124.598 49.110 1.00 7.47 ? 439 PHE M CB 1 ATOM 3493 C CG . PHE A 1 439 ? 28.047 125.316 47.874 1.00 6.88 ? 439 PHE M CG 1 ATOM 3494 C CD1 . PHE A 1 439 ? 26.992 124.814 47.117 1.00 8.42 ? 439 PHE M CD1 1 ATOM 3495 C CD2 . PHE A 1 439 ? 28.666 126.490 47.466 1.00 8.01 ? 439 PHE M CD2 1 ATOM 3496 C CE1 . PHE A 1 439 ? 26.562 125.467 45.968 1.00 9.34 ? 439 PHE M CE1 1 ATOM 3497 C CE2 . PHE A 1 439 ? 28.244 127.152 46.315 1.00 10.89 ? 439 PHE M CE2 1 ATOM 3498 C CZ . PHE A 1 439 ? 27.191 126.640 45.568 1.00 9.81 ? 439 PHE M CZ 1 ATOM 3499 N N . LEU A 1 440 ? 28.264 123.369 52.153 1.00 7.51 ? 440 LEU M N 1 ATOM 3500 C CA . LEU A 1 440 ? 28.285 122.180 52.998 1.00 6.62 ? 440 LEU M CA 1 ATOM 3501 C C . LEU A 1 440 ? 26.933 122.060 53.701 1.00 8.44 ? 440 LEU M C 1 ATOM 3502 O O . LEU A 1 440 ? 26.351 120.977 53.770 1.00 10.46 ? 440 LEU M O 1 ATOM 3503 C CB . LEU A 1 440 ? 29.421 122.257 54.019 1.00 8.46 ? 440 LEU M CB 1 ATOM 3504 C CG . LEU A 1 440 ? 29.643 121.008 54.879 1.00 9.42 ? 440 LEU M CG 1 ATOM 3505 C CD1 . LEU A 1 440 ? 29.979 119.790 54.004 1.00 11.77 ? 440 LEU M CD1 1 ATOM 3506 C CD2 . LEU A 1 440 ? 30.772 121.283 55.860 1.00 9.61 ? 440 LEU M CD2 1 ATOM 3507 N N . ASN A 1 441 ? 26.424 123.181 54.206 1.00 10.17 ? 441 ASN M N 1 ATOM 3508 C CA . ASN A 1 441 ? 25.121 123.186 54.868 1.00 11.22 ? 441 ASN M CA 1 ATOM 3509 C C . ASN A 1 441 ? 24.059 122.786 53.843 1.00 11.22 ? 441 ASN M C 1 ATOM 3510 O O . ASN A 1 441 ? 23.152 122.006 54.142 1.00 12.33 ? 441 ASN M O 1 ATOM 3511 C CB . ASN A 1 441 ? 24.816 124.579 55.424 1.00 11.67 ? 441 ASN M CB 1 ATOM 3512 C CG . ASN A 1 441 ? 23.412 124.691 55.985 1.00 19.00 ? 441 ASN M CG 1 ATOM 3513 O OD1 . ASN A 1 441 ? 22.991 123.883 56.811 1.00 21.80 ? 441 ASN M OD1 1 ATOM 3514 N ND2 . ASN A 1 441 ? 22.677 125.697 55.532 1.00 21.21 ? 441 ASN M ND2 1 ATOM 3515 N N . LYS A 1 442 ? 24.207 123.298 52.623 1.00 9.80 ? 442 LYS M N 1 ATOM 3516 C CA . LYS A 1 442 ? 23.271 123.013 51.539 1.00 10.47 ? 442 LYS M CA 1 ATOM 3517 C C . LYS A 1 442 ? 23.230 121.530 51.168 1.00 11.79 ? 442 LYS M C 1 ATOM 3518 O O . LYS A 1 442 ? 22.150 120.960 51.004 1.00 11.53 ? 442 LYS M O 1 ATOM 3519 C CB . LYS A 1 442 ? 23.618 123.867 50.312 1.00 13.45 ? 442 LYS M CB 1 ATOM 3520 C CG . LYS A 1 442 ? 22.656 123.747 49.134 1.00 14.17 ? 442 LYS M CG 1 ATOM 3521 C CD . LYS A 1 442 ? 23.145 124.611 47.966 1.00 17.33 ? 442 LYS M CD 1 ATOM 3522 C CE . LYS A 1 442 ? 22.370 124.362 46.680 1.00 19.64 ? 442 LYS M CE 1 ATOM 3523 N NZ . LYS A 1 442 ? 20.973 124.867 46.750 1.00 19.17 ? 442 LYS M NZ 1 ATOM 3524 N N . VAL A 1 443 ? 24.396 120.890 51.091 1.00 10.12 ? 443 VAL M N 1 ATOM 3525 C CA . VAL A 1 443 ? 24.442 119.479 50.726 1.00 9.23 ? 443 VAL M CA 1 ATOM 3526 C C . VAL A 1 443 ? 23.912 118.566 51.830 1.00 11.39 ? 443 VAL M C 1 ATOM 3527 O O . VAL A 1 443 ? 23.298 117.535 51.553 1.00 11.55 ? 443 VAL M O 1 ATOM 3528 C CB . VAL A 1 443 ? 25.862 119.042 50.276 1.00 8.75 ? 443 VAL M CB 1 ATOM 3529 C CG1 . VAL A 1 443 ? 26.796 118.855 51.470 1.00 9.59 ? 443 VAL M CG1 1 ATOM 3530 C CG2 . VAL A 1 443 ? 25.772 117.780 49.429 1.00 8.50 ? 443 VAL M CG2 1 ATOM 3531 N N . ILE A 1 444 ? 24.134 118.956 53.081 1.00 10.07 ? 444 ILE M N 1 ATOM 3532 C CA . ILE A 1 444 ? 23.652 118.171 54.212 1.00 9.81 ? 444 ILE M CA 1 ATOM 3533 C C . ILE A 1 444 ? 22.125 118.195 54.215 1.00 13.69 ? 444 ILE M C 1 ATOM 3534 O O . ILE A 1 444 ? 21.481 117.161 54.391 1.00 15.07 ? 444 ILE M O 1 ATOM 3535 C CB . ILE A 1 444 ? 24.190 118.727 55.548 1.00 10.02 ? 444 ILE M CB 1 ATOM 3536 C CG1 . ILE A 1 444 ? 25.702 118.514 55.625 1.00 10.69 ? 444 ILE M CG1 1 ATOM 3537 C CG2 . ILE A 1 444 ? 23.505 118.034 56.731 1.00 12.27 ? 444 ILE M CG2 1 ATOM 3538 C CD1 . ILE A 1 444 ? 26.363 119.236 56.787 1.00 11.62 ? 444 ILE M CD1 1 ATOM 3539 N N . LYS A 1 445 ? 21.553 119.368 53.963 1.00 12.97 ? 445 LYS M N 1 ATOM 3540 C CA . LYS A 1 445 ? 20.100 119.515 53.945 1.00 15.31 ? 445 LYS M CA 1 ATOM 3541 C C . LYS A 1 445 ? 19.410 118.949 52.707 1.00 16.37 ? 445 LYS M C 1 ATOM 3542 O O . LYS A 1 445 ? 18.359 118.312 52.815 1.00 17.47 ? 445 LYS M O 1 ATOM 3543 C CB . LYS A 1 445 ? 19.714 120.984 54.118 1.00 17.78 ? 445 LYS M CB 1 ATOM 3544 C CG . LYS A 1 445 ? 19.843 121.480 55.545 1.00 21.93 ? 445 LYS M CG 1 ATOM 3545 C CD . LYS A 1 445 ? 19.301 122.888 55.686 1.00 25.32 ? 445 LYS M CD 1 ATOM 3546 C CE . LYS A 1 445 ? 19.139 123.270 57.146 1.00 28.07 ? 445 LYS M CE 1 ATOM 3547 N NZ . LYS A 1 445 ? 20.389 123.062 57.917 1.00 27.45 ? 445 LYS M NZ 1 ATOM 3548 N N . GLU A 1 446 ? 20.002 119.168 51.539 1.00 12.74 ? 446 GLU M N 1 ATOM 3549 C CA . GLU A 1 446 ? 19.410 118.707 50.288 1.00 13.08 ? 446 GLU M CA 1 ATOM 3550 C C . GLU A 1 446 ? 19.679 117.261 49.916 1.00 13.79 ? 446 GLU M C 1 ATOM 3551 O O . GLU A 1 446 ? 18.816 116.598 49.345 1.00 14.62 ? 446 GLU M O 1 ATOM 3552 C CB . GLU A 1 446 ? 19.843 119.602 49.125 1.00 15.02 ? 446 GLU M CB 1 ATOM 3553 C CG . GLU A 1 446 ? 19.388 121.050 49.240 1.00 17.26 ? 446 GLU M CG 1 ATOM 3554 C CD . GLU A 1 446 ? 19.757 121.893 48.025 1.00 18.02 ? 446 GLU M CD 1 ATOM 3555 O OE1 . GLU A 1 446 ? 20.513 121.418 47.151 1.00 19.34 ? 446 GLU M OE1 1 ATOM 3556 O OE2 . GLU A 1 446 ? 19.289 123.046 47.944 1.00 20.98 ? 446 GLU M OE2 1 ATOM 3557 N N . LYS A 1 447 ? 20.876 116.778 50.225 1.00 11.33 ? 447 LYS M N 1 ATOM 3558 C CA . LYS A 1 447 ? 21.258 115.416 49.875 1.00 11.08 ? 447 LYS M CA 1 ATOM 3559 C C . LYS A 1 447 ? 21.345 114.464 51.054 1.00 11.57 ? 447 LYS M C 1 ATOM 3560 O O . LYS A 1 447 ? 21.594 113.276 50.868 1.00 12.94 ? 447 LYS M O 1 ATOM 3561 C CB . LYS A 1 447 ? 22.589 115.430 49.121 1.00 12.10 ? 447 LYS M CB 1 ATOM 3562 C CG . LYS A 1 447 ? 22.553 116.227 47.831 1.00 14.51 ? 447 LYS M CG 1 ATOM 3563 C CD . LYS A 1 447 ? 21.565 115.624 46.848 1.00 15.97 ? 447 LYS M CD 1 ATOM 3564 C CE . LYS A 1 447 ? 21.617 116.326 45.506 1.00 19.37 ? 447 LYS M CE 1 ATOM 3565 N NZ . LYS A 1 447 ? 20.700 115.668 44.532 1.00 20.96 ? 447 LYS M NZ 1 ATOM 3566 N N . ASP A 1 448 ? 21.166 114.998 52.259 1.00 12.15 ? 448 ASP M N 1 ATOM 3567 C CA . ASP A 1 448 ? 21.208 114.213 53.491 1.00 14.87 ? 448 ASP M CA 1 ATOM 3568 C C . ASP A 1 448 ? 22.544 113.490 53.682 1.00 13.03 ? 448 ASP M C 1 ATOM 3569 O O . ASP A 1 448 ? 22.584 112.344 54.124 1.00 13.24 ? 448 ASP M O 1 ATOM 3570 C CB . ASP A 1 448 ? 20.040 113.215 53.525 1.00 18.36 ? 448 ASP M CB 1 ATOM 3571 C CG . ASP A 1 448 ? 19.782 112.651 54.918 1.00 25.17 ? 448 ASP M CG 1 ATOM 3572 O OD1 . ASP A 1 448 ? 19.988 113.375 55.919 1.00 28.37 ? 448 ASP M OD1 1 ATOM 3573 O OD2 . ASP A 1 448 ? 19.361 111.479 55.008 1.00 28.88 ? 448 ASP M OD2 1 ATOM 3574 N N . VAL A 1 449 ? 23.638 114.154 53.319 1.00 12.16 ? 449 VAL M N 1 ATOM 3575 C CA . VAL A 1 449 ? 24.961 113.556 53.485 1.00 10.00 ? 449 VAL M CA 1 ATOM 3576 C C . VAL A 1 449 ? 25.263 113.575 54.976 1.00 8.90 ? 449 VAL M C 1 ATOM 3577 O O . VAL A 1 449 ? 24.981 114.563 55.659 1.00 9.38 ? 449 VAL M O 1 ATOM 3578 C CB . VAL A 1 449 ? 26.044 114.342 52.717 1.00 10.42 ? 449 VAL M CB 1 ATOM 3579 C CG1 . VAL A 1 449 ? 27.395 113.633 52.842 1.00 10.84 ? 449 VAL M CG1 1 ATOM 3580 C CG2 . VAL A 1 449 ? 25.655 114.465 51.247 1.00 10.95 ? 449 VAL M CG2 1 ATOM 3581 N N . ASN A 1 450 ? 25.825 112.479 55.479 1.00 8.55 ? 450 ASN M N 1 ATOM 3582 C CA . ASN A 1 450 ? 26.127 112.358 56.898 1.00 10.46 ? 450 ASN M CA 1 ATOM 3583 C C . ASN A 1 450 ? 27.429 113.027 57.332 1.00 10.06 ? 450 ASN M C 1 ATOM 3584 O O . ASN A 1 450 ? 28.372 112.357 57.757 1.00 9.25 ? 450 ASN M O 1 ATOM 3585 C CB . ASN A 1 450 ? 26.119 110.879 57.307 1.00 9.50 ? 450 ASN M CB 1 ATOM 3586 C CG . ASN A 1 450 ? 26.130 110.684 58.815 1.00 11.69 ? 450 ASN M CG 1 ATOM 3587 O OD1 . ASN A 1 450 ? 25.859 111.610 59.577 1.00 11.83 ? 450 ASN M OD1 1 ATOM 3588 N ND2 . ASN A 1 450 ? 26.442 109.467 59.249 1.00 12.29 ? 450 ASN M ND2 1 ATOM 3589 N N . VAL A 1 451 ? 27.468 114.353 57.221 1.00 9.43 ? 451 VAL M N 1 ATOM 3590 C CA . VAL A 1 451 ? 28.632 115.138 57.635 1.00 8.99 ? 451 VAL M CA 1 ATOM 3591 C C . VAL A 1 451 ? 28.350 115.605 59.058 1.00 9.80 ? 451 VAL M C 1 ATOM 3592 O O . VAL A 1 451 ? 27.298 116.194 59.327 1.00 11.57 ? 451 VAL M O 1 ATOM 3593 C CB . VAL A 1 451 ? 28.838 116.372 56.734 1.00 8.35 ? 451 VAL M CB 1 ATOM 3594 C CG1 . VAL A 1 451 ? 30.084 117.148 57.181 1.00 7.21 ? 451 VAL M CG1 1 ATOM 3595 C CG2 . VAL A 1 451 ? 28.971 115.946 55.279 1.00 9.14 ? 451 VAL M CG2 1 ATOM 3596 N N . LYS A 1 452 ? 29.273 115.332 59.975 1.00 8.81 ? 452 LYS M N 1 ATOM 3597 C CA . LYS A 1 452 ? 29.067 115.716 61.365 1.00 7.95 ? 452 LYS M CA 1 ATOM 3598 C C . LYS A 1 452 ? 30.088 116.683 61.943 1.00 7.99 ? 452 LYS M C 1 ATOM 3599 O O . LYS A 1 452 ? 30.014 117.038 63.118 1.00 9.49 ? 452 LYS M O 1 ATOM 3600 C CB . LYS A 1 452 ? 28.949 114.471 62.246 1.00 9.33 ? 452 LYS M CB 1 ATOM 3601 C CG . LYS A 1 452 ? 27.745 113.601 61.893 1.00 14.81 ? 452 LYS M CG 1 ATOM 3602 C CD . LYS A 1 452 ? 27.508 112.519 62.930 1.00 21.17 ? 452 LYS M CD 1 ATOM 3603 C CE . LYS A 1 452 ? 27.035 113.110 64.243 1.00 27.72 ? 452 LYS M CE 1 ATOM 3604 N NZ . LYS A 1 452 ? 25.764 113.867 64.065 1.00 32.42 ? 452 LYS M NZ 1 ATOM 3605 N N . GLY A 1 453 ? 31.018 117.143 61.112 1.00 9.88 ? 453 GLY M N 1 ATOM 3606 C CA . GLY A 1 453 ? 32.017 118.073 61.600 1.00 10.38 ? 453 GLY M CA 1 ATOM 3607 C C . GLY A 1 453 ? 32.775 118.776 60.495 1.00 8.47 ? 453 GLY M C 1 ATOM 3608 O O . GLY A 1 453 ? 32.834 118.298 59.366 1.00 8.31 ? 453 GLY M O 1 ATOM 3609 N N . TYR A 1 454 ? 33.363 119.916 60.838 1.00 7.65 ? 454 TYR M N 1 ATOM 3610 C CA . TYR A 1 454 ? 34.128 120.711 59.892 1.00 7.16 ? 454 TYR M CA 1 ATOM 3611 C C . TYR A 1 454 ? 35.313 121.332 60.615 1.00 8.39 ? 454 TYR M C 1 ATOM 3612 O O . TYR A 1 454 ? 35.147 122.033 61.610 1.00 8.09 ? 454 TYR M O 1 ATOM 3613 C CB . TYR A 1 454 ? 33.235 121.797 59.284 1.00 7.57 ? 454 TYR M CB 1 ATOM 3614 C CG . TYR A 1 454 ? 33.966 122.816 58.442 1.00 6.25 ? 454 TYR M CG 1 ATOM 3615 C CD1 . TYR A 1 454 ? 34.500 123.965 59.023 1.00 7.81 ? 454 TYR M CD1 1 ATOM 3616 C CD2 . TYR A 1 454 ? 34.100 122.647 57.065 1.00 6.87 ? 454 TYR M CD2 1 ATOM 3617 C CE1 . TYR A 1 454 ? 35.149 124.927 58.253 1.00 8.26 ? 454 TYR M CE1 1 ATOM 3618 C CE2 . TYR A 1 454 ? 34.746 123.600 56.281 1.00 7.69 ? 454 TYR M CE2 1 ATOM 3619 C CZ . TYR A 1 454 ? 35.264 124.738 56.884 1.00 7.71 ? 454 TYR M CZ 1 ATOM 3620 O OH . TYR A 1 454 ? 35.872 125.699 56.112 1.00 9.22 ? 454 TYR M OH 1 ATOM 3621 N N . LEU A 1 455 ? 36.509 121.055 60.108 1.00 7.70 ? 455 LEU M N 1 ATOM 3622 C CA . LEU A 1 455 ? 37.736 121.579 60.695 1.00 7.60 ? 455 LEU M CA 1 ATOM 3623 C C . LEU A 1 455 ? 38.489 122.358 59.621 1.00 9.50 ? 455 LEU M C 1 ATOM 3624 O O . LEU A 1 455 ? 38.966 121.783 58.637 1.00 10.55 ? 455 LEU M O 1 ATOM 3625 C CB . LEU A 1 455 ? 38.594 120.431 61.232 1.00 9.16 ? 455 LEU M CB 1 ATOM 3626 C CG . LEU A 1 455 ? 37.870 119.486 62.198 1.00 9.74 ? 455 LEU M CG 1 ATOM 3627 C CD1 . LEU A 1 455 ? 38.672 118.209 62.397 1.00 16.73 ? 455 LEU M CD1 1 ATOM 3628 C CD2 . LEU A 1 455 ? 37.622 120.187 63.528 1.00 12.55 ? 455 LEU M CD2 1 ATOM 3629 N N . ALA A 1 456 ? 38.564 123.671 59.800 1.00 7.51 ? 456 ALA M N 1 ATOM 3630 C CA . ALA A 1 456 ? 39.243 124.548 58.846 1.00 8.04 ? 456 ALA M CA 1 ATOM 3631 C C . ALA A 1 456 ? 40.751 124.357 58.930 1.00 8.66 ? 456 ALA M C 1 ATOM 3632 O O . ALA A 1 456 ? 41.303 124.192 60.020 1.00 8.65 ? 456 ALA M O 1 ATOM 3633 C CB . ALA A 1 456 ? 38.880 125.999 59.123 1.00 9.83 ? 456 ALA M CB 1 ATOM 3634 N N . TRP A 1 457 ? 41.426 124.407 57.788 1.00 8.20 ? 457 TRP M N 1 ATOM 3635 C CA . TRP A 1 457 ? 42.865 124.209 57.797 1.00 11.10 ? 457 TRP M CA 1 ATOM 3636 C C . TRP A 1 457 ? 43.707 125.322 58.396 1.00 22.81 ? 457 TRP M C 1 ATOM 3637 O O . TRP A 1 457 ? 43.581 126.493 58.052 1.00 22.11 ? 457 TRP M O 1 ATOM 3638 C CB . TRP A 1 457 ? 43.409 123.839 56.418 1.00 10.68 ? 457 TRP M CB 1 ATOM 3639 C CG . TRP A 1 457 ? 44.906 123.677 56.448 1.00 11.94 ? 457 TRP M CG 1 ATOM 3640 C CD1 . TRP A 1 457 ? 45.824 124.453 55.806 1.00 13.25 ? 457 TRP M CD1 1 ATOM 3641 C CD2 . TRP A 1 457 ? 45.656 122.734 57.231 1.00 10.44 ? 457 TRP M CD2 1 ATOM 3642 N NE1 . TRP A 1 457 ? 47.098 124.066 56.147 1.00 15.15 ? 457 TRP M NE1 1 ATOM 3643 C CE2 . TRP A 1 457 ? 47.024 123.012 57.019 1.00 14.29 ? 457 TRP M CE2 1 ATOM 3644 C CE3 . TRP A 1 457 ? 45.304 121.686 58.092 1.00 8.59 ? 457 TRP M CE3 1 ATOM 3645 C CZ2 . TRP A 1 457 ? 48.045 122.279 57.637 1.00 12.39 ? 457 TRP M CZ2 1 ATOM 3646 C CZ3 . TRP A 1 457 ? 46.319 120.955 58.706 1.00 9.65 ? 457 TRP M CZ3 1 ATOM 3647 C CH2 . TRP A 1 457 ? 47.673 121.257 58.474 1.00 11.59 ? 457 TRP M CH2 1 ATOM 3648 N N . ALA A 1 458 ? 44.617 124.895 59.264 1.00 25.29 ? 458 ALA M N 1 ATOM 3649 C CA . ALA A 1 458 ? 45.554 125.753 59.954 1.00 20.18 ? 458 ALA M CA 1 ATOM 3650 C C . ALA A 1 458 ? 44.968 126.660 61.019 1.00 16.97 ? 458 ALA M C 1 ATOM 3651 O O . ALA A 1 458 ? 44.364 127.706 60.744 1.00 10.55 ? 458 ALA M O 1 ATOM 3652 C CB . ALA A 1 458 ? 46.405 126.536 58.973 1.00 23.69 ? 458 ALA M CB 1 ATOM 3653 N N . LEU A 1 459 ? 45.143 126.212 62.253 1.00 14.23 ? 459 LEU M N 1 ATOM 3654 C CA . LEU A 1 459 ? 44.723 126.954 63.427 1.00 15.25 ? 459 LEU M CA 1 ATOM 3655 C C . LEU A 1 459 ? 45.500 128.271 63.360 1.00 16.62 ? 459 LEU M C 1 ATOM 3656 O O . LEU A 1 459 ? 44.972 129.339 63.668 1.00 16.51 ? 459 LEU M O 1 ATOM 3657 C CB . LEU A 1 459 ? 45.112 126.157 64.677 1.00 16.48 ? 459 LEU M CB 1 ATOM 3658 C CG . LEU A 1 459 ? 45.008 126.771 66.075 1.00 16.01 ? 459 LEU M CG 1 ATOM 3659 C CD1 . LEU A 1 459 ? 44.815 125.661 67.093 1.00 14.85 ? 459 LEU M CD1 1 ATOM 3660 C CD2 . LEU A 1 459 ? 46.250 127.591 66.406 1.00 18.39 ? 459 LEU M CD2 1 ATOM 3661 N N . GLY A 1 460 ? 46.744 128.171 62.902 1.00 15.71 ? 460 GLY M N 1 ATOM 3662 C CA . GLY A 1 460 ? 47.604 129.335 62.777 1.00 19.22 ? 460 GLY M CA 1 ATOM 3663 C C . GLY A 1 460 ? 48.606 129.159 61.652 1.00 17.91 ? 460 GLY M C 1 ATOM 3664 O O . GLY A 1 460 ? 48.641 128.108 61.011 1.00 20.91 ? 460 GLY M O 1 ATOM 3665 N N . ASP A 1 461 ? 49.402 130.194 61.389 1.00 16.15 ? 461 ASP M N 1 ATOM 3666 C CA . ASP A 1 461 ? 50.406 130.147 60.330 1.00 15.09 ? 461 ASP M CA 1 ATOM 3667 C C . ASP A 1 461 ? 51.528 129.203 60.723 1.00 21.09 ? 461 ASP M C 1 ATOM 3668 O O . ASP A 1 461 ? 52.027 129.261 61.842 1.00 24.55 ? 461 ASP M O 1 ATOM 3669 C CB . ASP A 1 461 ? 50.960 131.550 60.053 1.00 16.15 ? 461 ASP M CB 1 ATOM 3670 C CG . ASP A 1 461 ? 49.874 132.531 59.647 1.00 15.41 ? 461 ASP M CG 1 ATOM 3671 O OD1 . ASP A 1 461 ? 48.913 132.104 58.974 1.00 11.31 ? 461 ASP M OD1 1 ATOM 3672 O OD2 . ASP A 1 461 ? 49.981 133.725 59.997 1.00 13.56 ? 461 ASP M OD2 1 ATOM 3673 N N . ASN A 1 462 ? 51.949 128.362 59.785 1.00 17.14 ? 462 ASN M N 1 ATOM 3674 C CA . ASN A 1 462 ? 53.000 127.387 60.054 1.00 21.04 ? 462 ASN M CA 1 ATOM 3675 C C . ASN A 1 462 ? 53.819 127.081 58.805 1.00 17.80 ? 462 ASN M C 1 ATOM 3676 O O . ASN A 1 462 ? 53.674 127.748 57.781 1.00 16.75 ? 462 ASN M O 1 ATOM 3677 C CB . ASN A 1 462 ? 52.362 126.099 60.585 1.00 21.30 ? 462 ASN M CB 1 ATOM 3678 C CG . ASN A 1 462 ? 51.203 125.624 59.729 1.00 27.77 ? 462 ASN M CG 1 ATOM 3679 O OD1 . ASN A 1 462 ? 51.368 125.328 58.546 1.00 27.88 ? 462 ASN M OD1 1 ATOM 3680 N ND2 . ASN A 1 462 ? 50.016 125.558 60.325 1.00 31.90 ? 462 ASN M ND2 1 ATOM 3681 N N . TYR A 1 463 ? 54.711 126.098 58.899 1.00 17.19 ? 463 TYR M N 1 ATOM 3682 C CA . TYR A 1 463 ? 55.497 125.715 57.735 1.00 13.07 ? 463 TYR M CA 1 ATOM 3683 C C . TYR A 1 463 ? 54.537 124.989 56.811 1.00 10.66 ? 463 TYR M C 1 ATOM 3684 O O . TYR A 1 463 ? 53.830 124.082 57.229 1.00 10.96 ? 463 TYR M O 1 ATOM 3685 C CB . TYR A 1 463 ? 56.644 124.761 58.101 1.00 12.39 ? 463 TYR M CB 1 ATOM 3686 C CG . TYR A 1 463 ? 57.210 124.043 56.892 1.00 10.64 ? 463 TYR M CG 1 ATOM 3687 C CD1 . TYR A 1 463 ? 58.079 124.690 56.012 1.00 8.22 ? 463 TYR M CD1 1 ATOM 3688 C CD2 . TYR A 1 463 ? 56.810 122.741 56.581 1.00 8.78 ? 463 TYR M CD2 1 ATOM 3689 C CE1 . TYR A 1 463 ? 58.525 124.065 54.852 1.00 10.68 ? 463 TYR M CE1 1 ATOM 3690 C CE2 . TYR A 1 463 ? 57.254 122.108 55.422 1.00 9.43 ? 463 TYR M CE2 1 ATOM 3691 C CZ . TYR A 1 463 ? 58.106 122.778 54.560 1.00 9.93 ? 463 TYR M CZ 1 ATOM 3692 O OH . TYR A 1 463 ? 58.513 122.176 53.392 1.00 10.49 ? 463 TYR M OH 1 ATOM 3693 N N A GLU A 1 464 ? 54.509 125.399 55.552 0.68 12.95 ? 464 GLU M N 1 ATOM 3694 N N B GLU A 1 464 ? 54.507 125.396 55.552 0.52 12.77 ? 464 GLU M N 1 ATOM 3695 C CA A GLU A 1 464 ? 53.644 124.753 54.584 0.68 13.38 ? 464 GLU M CA 1 ATOM 3696 C CA B GLU A 1 464 ? 53.631 124.771 54.576 0.52 13.24 ? 464 GLU M CA 1 ATOM 3697 C C A GLU A 1 464 ? 54.471 123.894 53.651 0.68 12.91 ? 464 GLU M C 1 ATOM 3698 C C B GLU A 1 464 ? 54.467 123.896 53.649 0.52 12.69 ? 464 GLU M C 1 ATOM 3699 O O A GLU A 1 464 ? 55.420 124.374 53.032 0.68 15.27 ? 464 GLU M O 1 ATOM 3700 O O B GLU A 1 464 ? 55.422 124.374 53.034 0.52 14.52 ? 464 GLU M O 1 ATOM 3701 C CB A GLU A 1 464 ? 52.830 125.791 53.813 0.68 15.34 ? 464 GLU M CB 1 ATOM 3702 C CB B GLU A 1 464 ? 52.883 125.857 53.795 0.52 14.94 ? 464 GLU M CB 1 ATOM 3703 C CG A GLU A 1 464 ? 51.744 126.442 54.663 0.68 15.93 ? 464 GLU M CG 1 ATOM 3704 C CG B GLU A 1 464 ? 52.282 125.410 52.466 0.52 16.22 ? 464 GLU M CG 1 ATOM 3705 C CD A GLU A 1 464 ? 50.746 125.435 55.227 0.68 19.75 ? 464 GLU M CD 1 ATOM 3706 C CD B GLU A 1 464 ? 51.110 124.458 52.602 0.52 18.92 ? 464 GLU M CD 1 ATOM 3707 O OE1 A GLU A 1 464 ? 50.647 124.315 54.687 0.68 22.57 ? 464 GLU M OE1 1 ATOM 3708 O OE1 B GLU A 1 464 ? 50.724 124.139 53.739 0.52 19.85 ? 464 GLU M OE1 1 ATOM 3709 O OE2 A GLU A 1 464 ? 50.049 125.765 56.206 0.68 16.08 ? 464 GLU M OE2 1 ATOM 3710 O OE2 B GLU A 1 464 ? 50.568 124.042 51.558 0.52 19.41 ? 464 GLU M OE2 1 ATOM 3711 N N . PHE A 1 465 ? 54.125 122.610 53.584 1.00 11.47 ? 465 PHE M N 1 ATOM 3712 C CA . PHE A 1 465 ? 54.833 121.652 52.737 1.00 10.47 ? 465 PHE M CA 1 ATOM 3713 C C . PHE A 1 465 ? 55.047 122.210 51.334 1.00 13.52 ? 465 PHE M C 1 ATOM 3714 O O . PHE A 1 465 ? 54.108 122.707 50.717 1.00 15.58 ? 465 PHE M O 1 ATOM 3715 C CB . PHE A 1 465 ? 54.053 120.337 52.653 1.00 10.15 ? 465 PHE M CB 1 ATOM 3716 C CG . PHE A 1 465 ? 53.931 119.620 53.965 1.00 10.55 ? 465 PHE M CG 1 ATOM 3717 C CD1 . PHE A 1 465 ? 55.044 119.023 54.551 1.00 8.50 ? 465 PHE M CD1 1 ATOM 3718 C CD2 . PHE A 1 465 ? 52.694 119.496 54.595 1.00 9.78 ? 465 PHE M CD2 1 ATOM 3719 C CE1 . PHE A 1 465 ? 54.935 118.320 55.750 1.00 8.59 ? 465 PHE M CE1 1 ATOM 3720 C CE2 . PHE A 1 465 ? 52.571 118.795 55.793 1.00 9.88 ? 465 PHE M CE2 1 ATOM 3721 C CZ . PHE A 1 465 ? 53.690 118.199 56.370 1.00 11.92 ? 465 PHE M CZ 1 ATOM 3722 N N . ASN A 1 466 ? 56.303 122.196 50.890 1.00 13.65 ? 466 ASN M N 1 ATOM 3723 C CA . ASN A 1 466 ? 56.715 122.688 49.568 1.00 17.31 ? 466 ASN M CA 1 ATOM 3724 C C . ASN A 1 466 ? 56.786 124.202 49.434 1.00 15.85 ? 466 ASN M C 1 ATOM 3725 O O . ASN A 1 466 ? 57.416 124.703 48.504 1.00 18.47 ? 466 ASN M O 1 ATOM 3726 C CB . ASN A 1 466 ? 55.786 122.178 48.456 1.00 21.28 ? 466 ASN M CB 1 ATOM 3727 C CG . ASN A 1 466 ? 55.497 120.706 48.565 1.00 26.16 ? 466 ASN M CG 1 ATOM 3728 O OD1 . ASN A 1 466 ? 54.342 120.302 48.682 1.00 30.08 ? 466 ASN M OD1 1 ATOM 3729 N ND2 . ASN A 1 466 ? 56.541 119.896 48.557 1.00 26.49 ? 466 ASN M ND2 1 ATOM 3730 N N . LYS A 1 467 ? 56.135 124.927 50.339 1.00 15.76 ? 467 LYS M N 1 ATOM 3731 C CA . LYS A 1 467 ? 56.100 126.385 50.256 1.00 17.09 ? 467 LYS M CA 1 ATOM 3732 C C . LYS A 1 467 ? 56.851 127.139 51.345 1.00 17.65 ? 467 LYS M C 1 ATOM 3733 O O . LYS A 1 467 ? 56.961 128.362 51.285 1.00 15.53 ? 467 LYS M O 1 ATOM 3734 C CB . LYS A 1 467 ? 54.644 126.864 50.231 1.00 19.41 ? 467 LYS M CB 1 ATOM 3735 C CG . LYS A 1 467 ? 53.788 126.210 49.158 1.00 23.30 ? 467 LYS M CG 1 ATOM 3736 C CD . LYS A 1 467 ? 54.270 126.578 47.766 1.00 28.67 ? 467 LYS M CD 1 ATOM 3737 C CE . LYS A 1 467 ? 53.545 125.776 46.695 1.00 31.81 ? 467 LYS M CE 1 ATOM 3738 N NZ . LYS A 1 467 ? 52.069 125.979 46.730 1.00 34.54 ? 467 LYS M NZ 1 ATOM 3739 N N . GLY A 1 468 ? 57.363 126.422 52.340 1.00 16.96 ? 468 GLY M N 1 ATOM 3740 C CA . GLY A 1 468 ? 58.073 127.085 53.421 1.00 17.41 ? 468 GLY M CA 1 ATOM 3741 C C . GLY A 1 468 ? 57.147 128.030 54.166 1.00 18.20 ? 468 GLY M C 1 ATOM 3742 O O . GLY A 1 468 ? 56.071 127.635 54.621 1.00 17.10 ? 468 GLY M O 1 ATOM 3743 N N . PHE A 1 469 ? 57.555 129.291 54.268 1.00 17.75 ? 469 PHE M N 1 ATOM 3744 C CA . PHE A 1 469 ? 56.755 130.302 54.949 1.00 17.70 ? 469 PHE M CA 1 ATOM 3745 C C . PHE A 1 469 ? 56.322 131.396 53.972 1.00 18.95 ? 469 PHE M C 1 ATOM 3746 O O . PHE A 1 469 ? 55.950 132.495 54.383 1.00 18.59 ? 469 PHE M O 1 ATOM 3747 C CB . PHE A 1 469 ? 57.541 130.896 56.126 1.00 19.11 ? 469 PHE M CB 1 ATOM 3748 C CG . PHE A 1 469 ? 57.923 129.877 57.163 1.00 16.63 ? 469 PHE M CG 1 ATOM 3749 C CD1 . PHE A 1 469 ? 57.033 129.522 58.170 1.00 17.73 ? 469 PHE M CD1 1 ATOM 3750 C CD2 . PHE A 1 469 ? 59.160 129.242 57.109 1.00 18.95 ? 469 PHE M CD2 1 ATOM 3751 C CE1 . PHE A 1 469 ? 57.363 128.539 59.105 1.00 18.24 ? 469 PHE M CE1 1 ATOM 3752 C CE2 . PHE A 1 469 ? 59.501 128.261 58.035 1.00 15.08 ? 469 PHE M CE2 1 ATOM 3753 C CZ . PHE A 1 469 ? 58.601 127.910 59.038 1.00 16.75 ? 469 PHE M CZ 1 ATOM 3754 N N . THR A 1 470 ? 56.335 131.067 52.682 1.00 17.02 ? 470 THR M N 1 ATOM 3755 C CA . THR A 1 470 ? 55.950 132.011 51.635 1.00 20.90 ? 470 THR M CA 1 ATOM 3756 C C . THR A 1 470 ? 54.438 132.180 51.516 1.00 21.27 ? 470 THR M C 1 ATOM 3757 O O . THR A 1 470 ? 53.965 133.026 50.758 1.00 21.22 ? 470 THR M O 1 ATOM 3758 C CB . THR A 1 470 ? 56.524 131.615 50.261 1.00 21.73 ? 470 THR M CB 1 ATOM 3759 O OG1 . THR A 1 470 ? 55.988 130.353 49.853 1.00 18.63 ? 470 THR M OG1 1 ATOM 3760 C CG2 . THR A 1 470 ? 58.047 131.522 50.329 1.00 22.09 ? 470 THR M CG2 1 ATOM 3761 N N . VAL A 1 471 ? 53.690 131.326 52.210 1.00 19.67 ? 471 VAL M N 1 ATOM 3762 C CA . VAL A 1 471 ? 52.229 131.403 52.221 1.00 18.55 ? 471 VAL M CA 1 ATOM 3763 C C . VAL A 1 471 ? 51.736 131.151 53.642 1.00 19.05 ? 471 VAL M C 1 ATOM 3764 O O . VAL A 1 471 ? 52.385 130.444 54.418 1.00 16.69 ? 471 VAL M O 1 ATOM 3765 C CB . VAL A 1 471 ? 51.543 130.390 51.253 1.00 19.26 ? 471 VAL M CB 1 ATOM 3766 C CG1 . VAL A 1 471 ? 51.923 130.677 49.810 1.00 20.59 ? 471 VAL M CG1 1 ATOM 3767 C CG2 . VAL A 1 471 ? 51.881 128.957 51.629 1.00 20.33 ? 471 VAL M CG2 1 ATOM 3768 N N . ARG A 1 472 ? 50.618 131.777 53.989 1.00 14.35 ? 472 ARG M N 1 ATOM 3769 C CA . ARG A 1 472 ? 50.020 131.629 55.311 1.00 14.68 ? 472 ARG M CA 1 ATOM 3770 C C . ARG A 1 472 ? 48.636 131.009 55.149 1.00 14.70 ? 472 ARG M C 1 ATOM 3771 O O . ARG A 1 472 ? 47.890 131.396 54.257 1.00 13.32 ? 472 ARG M O 1 ATOM 3772 C CB . ARG A 1 472 ? 49.890 132.994 55.997 1.00 16.69 ? 472 ARG M CB 1 ATOM 3773 C CG . ARG A 1 472 ? 51.208 133.696 56.294 1.00 19.04 ? 472 ARG M CG 1 ATOM 3774 C CD . ARG A 1 472 ? 50.970 134.992 57.055 1.00 20.49 ? 472 ARG M CD 1 ATOM 3775 N NE . ARG A 1 472 ? 52.216 135.692 57.371 1.00 23.75 ? 472 ARG M NE 1 ATOM 3776 C CZ . ARG A 1 472 ? 52.890 135.561 58.511 1.00 25.83 ? 472 ARG M CZ 1 ATOM 3777 N NH1 . ARG A 1 472 ? 52.449 134.753 59.466 1.00 23.59 ? 472 ARG M NH1 1 ATOM 3778 N NH2 . ARG A 1 472 ? 54.014 136.242 58.697 1.00 25.56 ? 472 ARG M NH2 1 ATOM 3779 N N . PHE A 1 473 ? 48.313 130.022 55.983 1.00 11.16 ? 473 PHE M N 1 ATOM 3780 C CA . PHE A 1 473 ? 47.006 129.362 55.934 1.00 11.59 ? 473 PHE M CA 1 ATOM 3781 C C . PHE A 1 473 ? 46.226 129.531 57.236 1.00 9.29 ? 473 PHE M C 1 ATOM 3782 O O . PHE A 1 473 ? 45.064 129.143 57.323 1.00 11.06 ? 473 PHE M O 1 ATOM 3783 C CB . PHE A 1 473 ? 47.174 127.854 55.711 1.00 10.08 ? 473 PHE M CB 1 ATOM 3784 C CG . PHE A 1 473 ? 47.189 127.431 54.272 1.00 10.07 ? 473 PHE M CG 1 ATOM 3785 C CD1 . PHE A 1 473 ? 45.999 127.164 53.601 1.00 11.16 ? 473 PHE M CD1 1 ATOM 3786 C CD2 . PHE A 1 473 ? 48.390 127.245 53.601 1.00 13.84 ? 473 PHE M CD2 1 ATOM 3787 C CE1 . PHE A 1 473 ? 46.008 126.705 52.282 1.00 11.48 ? 473 PHE M CE1 1 ATOM 3788 C CE2 . PHE A 1 473 ? 48.411 126.786 52.281 1.00 12.77 ? 473 PHE M CE2 1 ATOM 3789 C CZ . PHE A 1 473 ? 47.219 126.519 51.621 1.00 13.01 ? 473 PHE M CZ 1 ATOM 3790 N N . GLY A 1 474 ? 46.864 130.101 58.250 1.00 9.65 ? 474 GLY M N 1 ATOM 3791 C CA . GLY A 1 474 ? 46.205 130.218 59.537 1.00 8.14 ? 474 GLY M CA 1 ATOM 3792 C C . GLY A 1 474 ? 45.045 131.172 59.733 1.00 9.87 ? 474 GLY M C 1 ATOM 3793 O O . GLY A 1 474 ? 44.910 132.178 59.031 1.00 9.65 ? 474 GLY M O 1 ATOM 3794 N N . LEU A 1 475 ? 44.152 130.801 60.646 1.00 8.05 ? 475 LEU M N 1 ATOM 3795 C CA . LEU A 1 475 ? 43.035 131.669 61.003 1.00 7.75 ? 475 LEU M CA 1 ATOM 3796 C C . LEU A 1 475 ? 43.560 132.598 62.101 1.00 10.54 ? 475 LEU M C 1 ATOM 3797 O O . LEU A 1 475 ? 42.923 133.593 62.451 1.00 11.28 ? 475 LEU M O 1 ATOM 3798 C CB . LEU A 1 475 ? 41.822 130.867 61.485 1.00 9.43 ? 475 LEU M CB 1 ATOM 3799 C CG . LEU A 1 475 ? 40.860 130.443 60.367 1.00 10.23 ? 475 LEU M CG 1 ATOM 3800 C CD1 . LEU A 1 475 ? 41.507 129.404 59.463 1.00 9.78 ? 475 LEU M CD1 1 ATOM 3801 C CD2 . LEU A 1 475 ? 39.576 129.895 60.978 1.00 12.44 ? 475 LEU M CD2 1 ATOM 3802 N N . SER A 1 476 ? 44.722 132.241 62.648 1.00 11.66 ? 476 SER M N 1 ATOM 3803 C CA . SER A 1 476 ? 45.395 133.040 63.668 1.00 13.63 ? 476 SER M CA 1 ATOM 3804 C C . SER A 1 476 ? 46.789 133.346 63.130 1.00 17.37 ? 476 SER M C 1 ATOM 3805 O O . SER A 1 476 ? 47.420 132.499 62.482 1.00 11.56 ? 476 SER M O 1 ATOM 3806 C CB . SER A 1 476 ? 45.458 132.319 65.026 1.00 12.14 ? 476 SER M CB 1 ATOM 3807 O OG . SER A 1 476 ? 46.253 131.150 64.996 1.00 13.16 ? 476 SER M OG 1 ATOM 3808 N N . TYR A 1 477 ? 47.218 134.590 63.336 1.00 19.32 ? 477 TYR M N 1 ATOM 3809 C CA . TYR A 1 477 ? 48.509 135.086 62.869 1.00 23.12 ? 477 TYR M CA 1 ATOM 3810 C C . TYR A 1 477 ? 49.671 134.750 63.793 1.00 23.35 ? 477 TYR M C 1 ATOM 3811 O O . TYR A 1 477 ? 49.521 134.698 65.016 1.00 23.60 ? 477 TYR M O 1 ATOM 3812 C CB . TYR A 1 477 ? 48.428 136.606 62.669 1.00 24.42 ? 477 TYR M CB 1 ATOM 3813 C CG . TYR A 1 477 ? 49.716 137.255 62.202 1.00 27.34 ? 477 TYR M CG 1 ATOM 3814 C CD1 . TYR A 1 477 ? 50.054 137.285 60.849 1.00 29.55 ? 477 TYR M CD1 1 ATOM 3815 C CD2 . TYR A 1 477 ? 50.590 137.847 63.113 1.00 29.48 ? 477 TYR M CD2 1 ATOM 3816 C CE1 . TYR A 1 477 ? 51.236 137.887 60.416 1.00 31.66 ? 477 TYR M CE1 1 ATOM 3817 C CE2 . TYR A 1 477 ? 51.773 138.451 62.690 1.00 31.40 ? 477 TYR M CE2 1 ATOM 3818 C CZ . TYR A 1 477 ? 52.087 138.469 61.341 1.00 31.24 ? 477 TYR M CZ 1 ATOM 3819 O OH . TYR A 1 477 ? 53.253 139.068 60.920 1.00 34.12 ? 477 TYR M OH 1 ATOM 3820 N N . ILE A 1 478 ? 50.834 134.529 63.189 1.00 24.34 ? 478 ILE M N 1 ATOM 3821 C CA . ILE A 1 478 ? 52.048 134.213 63.931 1.00 25.75 ? 478 ILE M CA 1 ATOM 3822 C C . ILE A 1 478 ? 53.227 135.005 63.373 1.00 27.30 ? 478 ILE M C 1 ATOM 3823 O O . ILE A 1 478 ? 53.524 134.936 62.179 1.00 25.49 ? 478 ILE M O 1 ATOM 3824 C CB . ILE A 1 478 ? 52.368 132.698 63.886 1.00 27.20 ? 478 ILE M CB 1 ATOM 3825 C CG1 . ILE A 1 478 ? 51.248 131.919 64.583 1.00 27.69 ? 478 ILE M CG1 1 ATOM 3826 C CG2 . ILE A 1 478 ? 53.700 132.416 64.578 1.00 29.42 ? 478 ILE M CG2 1 ATOM 3827 C CD1 . ILE A 1 478 ? 51.386 130.426 64.522 1.00 31.42 ? 478 ILE M CD1 1 ATOM 3828 N N . ASP A 1 479 ? 53.858 135.793 64.240 1.00 27.47 ? 479 ASP M N 1 ATOM 3829 C CA . ASP A 1 479 ? 55.016 136.601 63.869 1.00 28.90 ? 479 ASP M CA 1 ATOM 3830 C C . ASP A 1 479 ? 56.230 135.676 63.910 1.00 28.63 ? 479 ASP M C 1 ATOM 3831 O O . ASP A 1 479 ? 56.551 135.117 64.955 1.00 26.99 ? 479 ASP M O 1 ATOM 3832 C CB . ASP A 1 479 ? 55.193 137.748 64.874 1.00 31.13 ? 479 ASP M CB 1 ATOM 3833 C CG . ASP A 1 479 ? 56.192 138.803 64.408 1.00 33.73 ? 479 ASP M CG 1 ATOM 3834 O OD1 . ASP A 1 479 ? 57.167 138.468 63.704 1.00 31.17 ? 479 ASP M OD1 1 ATOM 3835 O OD2 . ASP A 1 479 ? 56.000 139.985 64.764 1.00 37.86 ? 479 ASP M OD2 1 ATOM 3836 N N . TRP A 1 480 ? 56.907 135.523 62.776 1.00 28.88 ? 480 TRP M N 1 ATOM 3837 C CA . TRP A 1 480 ? 58.071 134.646 62.709 1.00 30.60 ? 480 TRP M CA 1 ATOM 3838 C C . TRP A 1 480 ? 59.294 135.149 63.476 1.00 33.21 ? 480 TRP M C 1 ATOM 3839 O O . TRP A 1 480 ? 60.259 134.408 63.662 1.00 31.01 ? 480 TRP M O 1 ATOM 3840 C CB . TRP A 1 480 ? 58.410 134.315 61.253 1.00 29.73 ? 480 TRP M CB 1 ATOM 3841 C CG . TRP A 1 480 ? 57.285 133.590 60.568 1.00 28.11 ? 480 TRP M CG 1 ATOM 3842 C CD1 . TRP A 1 480 ? 56.633 133.972 59.431 1.00 28.59 ? 480 TRP M CD1 1 ATOM 3843 C CD2 . TRP A 1 480 ? 56.632 132.398 61.019 1.00 26.15 ? 480 TRP M CD2 1 ATOM 3844 N NE1 . TRP A 1 480 ? 55.609 133.099 59.152 1.00 25.04 ? 480 TRP M NE1 1 ATOM 3845 C CE2 . TRP A 1 480 ? 55.586 132.116 60.117 1.00 25.92 ? 480 TRP M CE2 1 ATOM 3846 C CE3 . TRP A 1 480 ? 56.825 131.532 62.109 1.00 27.09 ? 480 TRP M CE3 1 ATOM 3847 C CZ2 . TRP A 1 480 ? 54.734 131.021 60.260 1.00 24.45 ? 480 TRP M CZ2 1 ATOM 3848 C CZ3 . TRP A 1 480 ? 55.978 130.438 62.257 1.00 24.84 ? 480 TRP M CZ3 1 ATOM 3849 C CH2 . TRP A 1 480 ? 54.947 130.193 61.336 1.00 26.68 ? 480 TRP M CH2 1 ATOM 3850 N N . ASN A 1 481 ? 59.238 136.397 63.938 1.00 34.54 ? 481 ASN M N 1 ATOM 3851 C CA . ASN A 1 481 ? 60.328 136.985 64.719 1.00 37.58 ? 481 ASN M CA 1 ATOM 3852 C C . ASN A 1 481 ? 60.095 136.716 66.209 1.00 38.78 ? 481 ASN M C 1 ATOM 3853 O O . ASN A 1 481 ? 61.005 136.850 67.029 1.00 38.17 ? 481 ASN M O 1 ATOM 3854 C CB . ASN A 1 481 ? 60.427 138.492 64.466 1.00 38.98 ? 481 ASN M CB 1 ATOM 3855 C CG . ASN A 1 481 ? 60.834 138.820 63.041 1.00 41.08 ? 481 ASN M CG 1 ATOM 3856 O OD1 . ASN A 1 481 ? 61.700 138.164 62.461 1.00 42.26 ? 481 ASN M OD1 1 ATOM 3857 N ND2 . ASN A 1 481 ? 60.211 139.844 62.470 1.00 43.14 ? 481 ASN M ND2 1 ATOM 3858 N N . ASN A 1 482 ? 58.858 136.355 66.540 1.00 38.53 ? 482 ASN M N 1 ATOM 3859 C CA . ASN A 1 482 ? 58.447 136.035 67.905 1.00 40.51 ? 482 ASN M CA 1 ATOM 3860 C C . ASN A 1 482 ? 57.170 135.208 67.775 1.00 39.55 ? 482 ASN M C 1 ATOM 3861 O O . ASN A 1 482 ? 56.058 135.736 67.834 1.00 36.18 ? 482 ASN M O 1 ATOM 3862 C CB . ASN A 1 482 ? 58.182 137.309 68.713 1.00 44.29 ? 482 ASN M CB 1 ATOM 3863 C CG . ASN A 1 482 ? 58.007 137.032 70.197 1.00 48.34 ? 482 ASN M CG 1 ATOM 3864 O OD1 . ASN A 1 482 ? 57.743 135.897 70.602 1.00 48.21 ? 482 ASN M OD1 1 ATOM 3865 N ND2 . ASN A 1 482 ? 58.163 138.071 71.011 1.00 52.35 ? 482 ASN M ND2 1 ATOM 3866 N N . VAL A 1 483 ? 57.355 133.904 67.586 1.00 38.12 ? 483 VAL M N 1 ATOM 3867 C CA . VAL A 1 483 ? 56.262 132.954 67.387 1.00 37.32 ? 483 VAL M CA 1 ATOM 3868 C C . VAL A 1 483 ? 55.369 132.625 68.584 1.00 37.22 ? 483 VAL M C 1 ATOM 3869 O O . VAL A 1 483 ? 54.456 131.808 68.462 1.00 34.92 ? 483 VAL M O 1 ATOM 3870 C CB . VAL A 1 483 ? 56.801 131.625 66.807 1.00 37.42 ? 483 VAL M CB 1 ATOM 3871 C CG1 . VAL A 1 483 ? 57.622 131.894 65.554 1.00 36.56 ? 483 VAL M CG1 1 ATOM 3872 C CG2 . VAL A 1 483 ? 57.640 130.891 67.848 1.00 39.10 ? 483 VAL M CG2 1 ATOM 3873 N N . THR A 1 484 ? 55.610 133.267 69.723 1.00 34.98 ? 484 THR M N 1 ATOM 3874 C CA . THR A 1 484 ? 54.824 133.007 70.927 1.00 33.60 ? 484 THR M CA 1 ATOM 3875 C C . THR A 1 484 ? 53.315 133.204 70.758 1.00 33.59 ? 484 THR M C 1 ATOM 3876 O O . THR A 1 484 ? 52.535 132.278 70.986 1.00 31.50 ? 484 THR M O 1 ATOM 3877 C CB . THR A 1 484 ? 55.312 133.868 72.112 1.00 35.39 ? 484 THR M CB 1 ATOM 3878 O OG1 . THR A 1 484 ? 56.693 133.584 72.373 1.00 36.26 ? 484 THR M OG1 1 ATOM 3879 C CG2 . THR A 1 484 ? 54.499 133.569 73.363 1.00 33.94 ? 484 THR M CG2 1 ATOM 3880 N N . ASP A 1 485 ? 52.916 134.401 70.337 1.00 33.13 ? 485 ASP M N 1 ATOM 3881 C CA . ASP A 1 485 ? 51.504 134.731 70.166 1.00 33.98 ? 485 ASP M CA 1 ATOM 3882 C C . ASP A 1 485 ? 50.774 134.136 68.968 1.00 33.65 ? 485 ASP M C 1 ATOM 3883 O O . ASP A 1 485 ? 51.349 133.924 67.899 1.00 29.77 ? 485 ASP M O 1 ATOM 3884 C CB . ASP A 1 485 ? 51.309 136.252 70.171 1.00 36.54 ? 485 ASP M CB 1 ATOM 3885 C CG . ASP A 1 485 ? 51.453 136.862 71.557 1.00 39.44 ? 485 ASP M CG 1 ATOM 3886 O OD1 . ASP A 1 485 ? 51.802 136.135 72.513 1.00 39.66 ? 485 ASP M OD1 1 ATOM 3887 O OD2 . ASP A 1 485 ? 51.211 138.080 71.690 1.00 41.63 ? 485 ASP M OD2 1 ATOM 3888 N N . ARG A 1 486 ? 49.484 133.889 69.180 1.00 31.74 ? 486 ARG M N 1 ATOM 3889 C CA . ARG A 1 486 ? 48.579 133.350 68.174 1.00 32.08 ? 486 ARG M CA 1 ATOM 3890 C C . ARG A 1 486 ? 47.398 134.324 68.180 1.00 28.67 ? 486 ARG M C 1 ATOM 3891 O O . ARG A 1 486 ? 46.461 134.162 68.958 1.00 29.22 ? 486 ARG M O 1 ATOM 3892 C CB . ARG A 1 486 ? 48.074 131.964 68.592 1.00 31.92 ? 486 ARG M CB 1 ATOM 3893 C CG . ARG A 1 486 ? 49.134 130.946 68.994 1.00 34.62 ? 486 ARG M CG 1 ATOM 3894 C CD . ARG A 1 486 ? 49.866 130.395 67.794 1.00 37.98 ? 486 ARG M CD 1 ATOM 3895 N NE . ARG A 1 486 ? 50.529 129.124 68.091 1.00 39.74 ? 486 ARG M NE 1 ATOM 3896 C CZ . ARG A 1 486 ? 51.757 129.004 68.588 1.00 37.26 ? 486 ARG M CZ 1 ATOM 3897 N NH1 . ARG A 1 486 ? 52.481 130.081 68.860 1.00 37.08 ? 486 ARG M NH1 1 ATOM 3898 N NH2 . ARG A 1 486 ? 52.275 127.799 68.781 1.00 36.57 ? 486 ARG M NH2 1 ATOM 3899 N N . ASP A 1 487 ? 47.468 135.357 67.347 1.00 26.62 ? 487 ASP M N 1 ATOM 3900 C CA . ASP A 1 487 ? 46.405 136.361 67.288 1.00 25.40 ? 487 ASP M CA 1 ATOM 3901 C C . ASP A 1 487 ? 45.393 136.087 66.182 1.00 22.28 ? 487 ASP M C 1 ATOM 3902 O O . ASP A 1 487 ? 45.762 135.971 65.014 1.00 19.51 ? 487 ASP M O 1 ATOM 3903 C CB . ASP A 1 487 ? 47.008 137.755 67.093 1.00 28.36 ? 487 ASP M CB 1 ATOM 3904 C CG . ASP A 1 487 ? 48.044 138.098 68.150 1.00 32.16 ? 487 ASP M CG 1 ATOM 3905 O OD1 . ASP A 1 487 ? 47.743 137.960 69.354 1.00 34.74 ? 487 ASP M OD1 1 ATOM 3906 O OD2 . ASP A 1 487 ? 49.163 138.505 67.773 1.00 34.38 ? 487 ASP M OD2 1 ATOM 3907 N N . LEU A 1 488 ? 44.113 136.029 66.544 1.00 16.39 ? 488 LEU M N 1 ATOM 3908 C CA . LEU A 1 488 ? 43.064 135.779 65.559 1.00 14.49 ? 488 LEU M CA 1 ATOM 3909 C C . LEU A 1 488 ? 43.037 136.850 64.479 1.00 14.32 ? 488 LEU M C 1 ATOM 3910 O O . LEU A 1 488 ? 43.028 138.051 64.770 1.00 12.68 ? 488 LEU M O 1 ATOM 3911 C CB . LEU A 1 488 ? 41.680 135.717 66.215 1.00 15.80 ? 488 LEU M CB 1 ATOM 3912 C CG . LEU A 1 488 ? 41.310 134.535 67.111 1.00 18.44 ? 488 LEU M CG 1 ATOM 3913 C CD1 . LEU A 1 488 ? 39.852 134.677 67.535 1.00 18.12 ? 488 LEU M CD1 1 ATOM 3914 C CD2 . LEU A 1 488 ? 41.509 133.226 66.362 1.00 17.16 ? 488 LEU M CD2 1 ATOM 3915 N N . LYS A 1 489 ? 43.060 136.402 63.229 1.00 10.91 ? 489 LYS M N 1 ATOM 3916 C CA . LYS A 1 489 ? 42.995 137.305 62.088 1.00 11.21 ? 489 LYS M CA 1 ATOM 3917 C C . LYS A 1 489 ? 41.518 137.656 61.911 1.00 11.03 ? 489 LYS M C 1 ATOM 3918 O O . LYS A 1 489 ? 40.678 137.231 62.708 1.00 12.69 ? 489 LYS M O 1 ATOM 3919 C CB . LYS A 1 489 ? 43.497 136.595 60.831 1.00 10.46 ? 489 LYS M CB 1 ATOM 3920 C CG . LYS A 1 489 ? 44.922 136.087 60.915 1.00 10.55 ? 489 LYS M CG 1 ATOM 3921 C CD . LYS A 1 489 ? 45.292 135.369 59.634 1.00 11.80 ? 489 LYS M CD 1 ATOM 3922 C CE . LYS A 1 489 ? 46.687 134.779 59.705 1.00 9.56 ? 489 LYS M CE 1 ATOM 3923 N NZ . LYS A 1 489 ? 47.000 134.021 58.463 1.00 9.36 ? 489 LYS M NZ 1 ATOM 3924 N N . LYS A 1 490 ? 41.192 138.422 60.875 1.00 11.37 ? 490 LYS M N 1 ATOM 3925 C CA . LYS A 1 490 ? 39.793 138.763 60.622 1.00 12.04 ? 490 LYS M CA 1 ATOM 3926 C C . LYS A 1 490 ? 38.993 137.479 60.407 1.00 13.23 ? 490 LYS M C 1 ATOM 3927 O O . LYS A 1 490 ? 37.840 137.382 60.831 1.00 13.15 ? 490 LYS M O 1 ATOM 3928 C CB . LYS A 1 490 ? 39.656 139.673 59.398 1.00 13.48 ? 490 LYS M CB 1 ATOM 3929 C CG . LYS A 1 490 ? 40.018 141.126 59.648 1.00 18.55 ? 490 LYS M CG 1 ATOM 3930 C CD . LYS A 1 490 ? 38.991 141.806 60.546 1.00 22.05 ? 490 LYS M CD 1 ATOM 3931 C CE . LYS A 1 490 ? 39.321 143.278 60.728 1.00 23.64 ? 490 LYS M CE 1 ATOM 3932 N NZ . LYS A 1 490 ? 38.284 143.990 61.522 1.00 27.79 ? 490 LYS M NZ 1 ATOM 3933 N N . SER A 1 491 ? 39.612 136.491 59.758 1.00 11.70 ? 491 SER M N 1 ATOM 3934 C CA . SER A 1 491 ? 38.953 135.209 59.513 1.00 10.54 ? 491 SER M CA 1 ATOM 3935 C C . SER A 1 491 ? 38.671 134.499 60.833 1.00 9.27 ? 491 SER M C 1 ATOM 3936 O O . SER A 1 491 ? 37.591 133.948 61.025 1.00 9.93 ? 491 SER M O 1 ATOM 3937 C CB . SER A 1 491 ? 39.814 134.314 58.621 1.00 9.70 ? 491 SER M CB 1 ATOM 3938 O OG . SER A 1 491 ? 41.063 134.041 59.230 1.00 12.62 ? 491 SER M OG 1 ATOM 3939 N N . GLY A 1 492 ? 39.660 134.503 61.727 1.00 11.27 ? 492 GLY M N 1 ATOM 3940 C CA . GLY A 1 492 ? 39.497 133.877 63.029 1.00 11.12 ? 492 GLY M CA 1 ATOM 3941 C C . GLY A 1 492 ? 38.385 134.554 63.811 1.00 10.83 ? 492 GLY M C 1 ATOM 3942 O O . GLY A 1 492 ? 37.579 133.889 64.456 1.00 10.04 ? 492 GLY M O 1 ATOM 3943 N N . GLN A 1 493 ? 38.328 135.883 63.730 1.00 11.97 ? 493 GLN M N 1 ATOM 3944 C CA . GLN A 1 493 ? 37.295 136.649 64.419 1.00 12.62 ? 493 GLN M CA 1 ATOM 3945 C C . GLN A 1 493 ? 35.921 136.349 63.823 1.00 11.72 ? 493 GLN M C 1 ATOM 3946 O O . GLN A 1 493 ? 34.931 136.253 64.549 1.00 12.59 ? 493 GLN M O 1 ATOM 3947 C CB . GLN A 1 493 ? 37.610 138.147 64.341 1.00 13.32 ? 493 GLN M CB 1 ATOM 3948 C CG . GLN A 1 493 ? 38.895 138.525 65.064 1.00 19.30 ? 493 GLN M CG 1 ATOM 3949 C CD . GLN A 1 493 ? 39.376 139.918 64.717 1.00 24.34 ? 493 GLN M CD 1 ATOM 3950 O OE1 . GLN A 1 493 ? 38.587 140.858 64.643 1.00 27.35 ? 493 GLN M OE1 1 ATOM 3951 N NE2 . GLN A 1 493 ? 40.678 140.056 64.491 1.00 26.98 ? 493 GLN M NE2 1 ATOM 3952 N N . TRP A 1 494 ? 35.863 136.197 62.501 1.00 11.35 ? 494 TRP M N 1 ATOM 3953 C CA . TRP A 1 494 ? 34.605 135.872 61.840 1.00 11.24 ? 494 TRP M CA 1 ATOM 3954 C C . TRP A 1 494 ? 34.153 134.471 62.259 1.00 11.85 ? 494 TRP M C 1 ATOM 3955 O O . TRP A 1 494 ? 32.987 134.256 62.583 1.00 11.97 ? 494 TRP M O 1 ATOM 3956 C CB . TRP A 1 494 ? 34.748 135.920 60.313 1.00 9.60 ? 494 TRP M CB 1 ATOM 3957 C CG . TRP A 1 494 ? 33.673 135.126 59.627 1.00 9.23 ? 494 TRP M CG 1 ATOM 3958 C CD1 . TRP A 1 494 ? 32.373 135.498 59.440 1.00 11.37 ? 494 TRP M CD1 1 ATOM 3959 C CD2 . TRP A 1 494 ? 33.773 133.774 59.166 1.00 10.71 ? 494 TRP M CD2 1 ATOM 3960 N NE1 . TRP A 1 494 ? 31.652 134.457 58.908 1.00 14.15 ? 494 TRP M NE1 1 ATOM 3961 C CE2 . TRP A 1 494 ? 32.490 133.384 58.726 1.00 12.77 ? 494 TRP M CE2 1 ATOM 3962 C CE3 . TRP A 1 494 ? 34.826 132.848 59.088 1.00 12.92 ? 494 TRP M CE3 1 ATOM 3963 C CZ2 . TRP A 1 494 ? 32.223 132.109 58.222 1.00 14.71 ? 494 TRP M CZ2 1 ATOM 3964 C CZ3 . TRP A 1 494 ? 34.561 131.580 58.588 1.00 14.32 ? 494 TRP M CZ3 1 ATOM 3965 C CH2 . TRP A 1 494 ? 33.270 131.224 58.159 1.00 13.89 ? 494 TRP M CH2 1 ATOM 3966 N N . TYR A 1 495 ? 35.083 133.519 62.222 1.00 10.75 ? 495 TYR M N 1 ATOM 3967 C CA . TYR A 1 495 ? 34.789 132.131 62.576 1.00 9.83 ? 495 TYR M CA 1 ATOM 3968 C C . TYR A 1 495 ? 34.260 132.050 64.002 1.00 10.01 ? 495 TYR M C 1 ATOM 3969 O O . TYR A 1 495 ? 33.362 131.264 64.295 1.00 10.98 ? 495 TYR M O 1 ATOM 3970 C CB . TYR A 1 495 ? 36.048 131.276 62.403 1.00 9.87 ? 495 TYR M CB 1 ATOM 3971 C CG . TYR A 1 495 ? 35.815 129.777 62.323 1.00 10.11 ? 495 TYR M CG 1 ATOM 3972 C CD1 . TYR A 1 495 ? 34.694 129.249 61.679 1.00 10.64 ? 495 TYR M CD1 1 ATOM 3973 C CD2 . TYR A 1 495 ? 36.751 128.887 62.848 1.00 9.41 ? 495 TYR M CD2 1 ATOM 3974 C CE1 . TYR A 1 495 ? 34.518 127.865 61.557 1.00 10.64 ? 495 TYR M CE1 1 ATOM 3975 C CE2 . TYR A 1 495 ? 36.587 127.511 62.728 1.00 10.25 ? 495 TYR M CE2 1 ATOM 3976 C CZ . TYR A 1 495 ? 35.475 127.005 62.082 1.00 9.32 ? 495 TYR M CZ 1 ATOM 3977 O OH . TYR A 1 495 ? 35.339 125.639 61.943 1.00 8.01 ? 495 TYR M OH 1 ATOM 3978 N N . GLN A 1 496 ? 34.799 132.899 64.871 1.00 11.58 ? 496 GLN M N 1 ATOM 3979 C CA . GLN A 1 496 ? 34.376 132.962 66.267 1.00 12.39 ? 496 GLN M CA 1 ATOM 3980 C C . GLN A 1 496 ? 32.898 133.356 66.306 1.00 12.75 ? 496 GLN M C 1 ATOM 3981 O O . GLN A 1 496 ? 32.096 132.742 67.010 1.00 12.55 ? 496 GLN M O 1 ATOM 3982 C CB . GLN A 1 496 ? 35.219 133.999 67.011 1.00 14.36 ? 496 GLN M CB 1 ATOM 3983 C CG . GLN A 1 496 ? 34.858 134.189 68.474 1.00 17.57 ? 496 GLN M CG 1 ATOM 3984 C CD . GLN A 1 496 ? 35.663 135.299 69.122 1.00 21.51 ? 496 GLN M CD 1 ATOM 3985 O OE1 . GLN A 1 496 ? 35.752 136.409 68.593 1.00 24.82 ? 496 GLN M OE1 1 ATOM 3986 N NE2 . GLN A 1 496 ? 36.259 135.006 70.269 1.00 23.20 ? 496 GLN M NE2 1 ATOM 3987 N N . SER A 1 497 ? 32.540 134.368 65.521 1.00 12.68 ? 497 SER M N 1 ATOM 3988 C CA . SER A 1 497 ? 31.158 134.830 65.464 1.00 14.14 ? 497 SER M CA 1 ATOM 3989 C C . SER A 1 497 ? 30.270 133.776 64.801 1.00 11.83 ? 497 SER M C 1 ATOM 3990 O O . SER A 1 497 ? 29.142 133.541 65.233 1.00 13.23 ? 497 SER M O 1 ATOM 3991 C CB . SER A 1 497 ? 31.073 136.163 64.716 1.00 15.46 ? 497 SER M CB 1 ATOM 3992 O OG . SER A 1 497 ? 29.761 136.696 64.785 1.00 27.26 ? 497 SER M OG 1 ATOM 3993 N N . PHE A 1 498 ? 30.790 133.128 63.759 1.00 10.14 ? 498 PHE M N 1 ATOM 3994 C CA . PHE A 1 498 ? 30.046 132.082 63.065 1.00 9.87 ? 498 PHE M CA 1 ATOM 3995 C C . PHE A 1 498 ? 29.675 130.967 64.044 1.00 9.53 ? 498 PHE M C 1 ATOM 3996 O O . PHE A 1 498 ? 28.534 130.501 64.064 1.00 12.40 ? 498 PHE M O 1 ATOM 3997 C CB . PHE A 1 498 ? 30.890 131.504 61.917 1.00 11.48 ? 498 PHE M CB 1 ATOM 3998 C CG . PHE A 1 498 ? 30.313 130.255 61.305 1.00 10.87 ? 498 PHE M CG 1 ATOM 3999 C CD1 . PHE A 1 498 ? 30.609 129.001 61.839 1.00 14.10 ? 498 PHE M CD1 1 ATOM 4000 C CD2 . PHE A 1 498 ? 29.471 130.329 60.202 1.00 13.47 ? 498 PHE M CD2 1 ATOM 4001 C CE1 . PHE A 1 498 ? 30.062 127.845 61.292 1.00 11.83 ? 498 PHE M CE1 1 ATOM 4002 C CE2 . PHE A 1 498 ? 28.919 129.175 59.647 1.00 12.35 ? 498 PHE M CE2 1 ATOM 4003 C CZ . PHE A 1 498 ? 29.219 127.932 60.193 1.00 12.03 ? 498 PHE M CZ 1 ATOM 4004 N N . ILE A 1 499 ? 30.645 130.562 64.861 1.00 9.23 ? 499 ILE M N 1 ATOM 4005 C CA . ILE A 1 499 ? 30.449 129.489 65.836 1.00 10.66 ? 499 ILE M CA 1 ATOM 4006 C C . ILE A 1 499 ? 29.474 129.874 66.947 1.00 14.61 ? 499 ILE M C 1 ATOM 4007 O O . ILE A 1 499 ? 28.631 129.067 67.342 1.00 14.01 ? 499 ILE M O 1 ATOM 4008 C CB . ILE A 1 499 ? 31.799 129.033 66.443 1.00 11.87 ? 499 ILE M CB 1 ATOM 4009 C CG1 . ILE A 1 499 ? 32.660 128.375 65.356 1.00 10.28 ? 499 ILE M CG1 1 ATOM 4010 C CG2 . ILE A 1 499 ? 31.569 128.060 67.599 1.00 12.90 ? 499 ILE M CG2 1 ATOM 4011 C CD1 . ILE A 1 499 ? 34.055 127.989 65.816 1.00 11.65 ? 499 ILE M CD1 1 ATOM 4012 N N . SER A 1 500 ? 29.594 131.104 67.438 1.00 13.83 ? 500 SER M N 1 ATOM 4013 C CA . SER A 1 500 ? 28.725 131.605 68.501 1.00 16.05 ? 500 SER M CA 1 ATOM 4014 C C . SER A 1 500 ? 28.127 132.934 68.042 1.00 15.85 ? 500 SER M C 1 ATOM 4015 O O . SER A 1 500 ? 28.577 134.002 68.455 1.00 17.18 ? 500 SER M O 1 ATOM 4016 C CB . SER A 1 500 ? 29.531 131.804 69.787 1.00 17.82 ? 500 SER M CB 1 ATOM 4017 O OG . SER A 1 500 ? 30.225 130.619 70.138 1.00 17.59 ? 500 SER M OG 1 ATOM 4018 N N . PRO A 1 501 ? 27.098 132.879 67.180 1.00 18.37 ? 501 PRO M N 1 ATOM 4019 C CA . PRO A 1 501 ? 26.434 134.075 66.650 1.00 19.84 ? 501 PRO M CA 1 ATOM 4020 C C . PRO A 1 501 ? 25.679 134.908 67.686 1.00 22.82 ? 501 PRO M C 1 ATOM 4021 O O . PRO A 1 501 ? 25.470 136.111 67.414 1.00 25.73 ? 501 PRO M O 1 ATOM 4022 C CB . PRO A 1 501 ? 25.502 133.498 65.585 1.00 18.96 ? 501 PRO M CB 1 ATOM 4023 C CG . PRO A 1 501 ? 25.142 132.167 66.142 1.00 19.93 ? 501 PRO M CG 1 ATOM 4024 C CD . PRO A 1 501 ? 26.471 131.657 66.646 1.00 17.01 ? 501 PRO M CD 1 ATOM 4025 O OXT . PRO A 1 501 ? 25.324 134.362 68.752 1.00 25.90 ? 501 PRO M OXT 1 HETATM 4026 C C1 . NAG B 2 . ? 21.956 132.318 62.250 1.00 29.57 ? 901 NAG M C1 1 HETATM 4027 C C2 . NAG B 2 . ? 21.247 133.524 62.868 1.00 31.03 ? 901 NAG M C2 1 HETATM 4028 C C3 . NAG B 2 . ? 19.732 133.393 62.693 1.00 33.66 ? 901 NAG M C3 1 HETATM 4029 C C4 . NAG B 2 . ? 19.394 133.146 61.226 1.00 34.52 ? 901 NAG M C4 1 HETATM 4030 C C5 . NAG B 2 . ? 20.173 131.934 60.725 1.00 35.11 ? 901 NAG M C5 1 HETATM 4031 C C6 . NAG B 2 . ? 19.926 131.631 59.263 1.00 34.46 ? 901 NAG M C6 1 HETATM 4032 C C7 . NAG B 2 . ? 22.007 134.750 64.800 1.00 31.07 ? 901 NAG M C7 1 HETATM 4033 C C8 . NAG B 2 . ? 22.101 134.828 66.314 1.00 32.02 ? 901 NAG M C8 1 HETATM 4034 N N2 . NAG B 2 . ? 21.573 133.607 64.280 1.00 30.94 ? 901 NAG M N2 1 HETATM 4035 O O3 . NAG B 2 . ? 19.093 134.583 63.135 1.00 35.44 ? 901 NAG M O3 1 HETATM 4036 O O4 . NAG B 2 . ? 17.998 132.916 61.084 1.00 38.37 ? 901 NAG M O4 1 HETATM 4037 O O5 . NAG B 2 . ? 21.584 132.168 60.878 1.00 30.04 ? 901 NAG M O5 1 HETATM 4038 O O6 . NAG B 2 . ? 20.430 130.349 58.916 1.00 39.61 ? 901 NAG M O6 1 HETATM 4039 O O7 . NAG B 2 . ? 22.324 135.723 64.115 1.00 33.88 ? 901 NAG M O7 1 HETATM 4040 C C1 . NAG C 2 . ? 30.258 128.773 73.353 1.00 22.94 ? 911 NAG M C1 1 HETATM 4041 C C2 . NAG C 2 . ? 29.601 130.019 73.959 1.00 25.05 ? 911 NAG M C2 1 HETATM 4042 C C3 . NAG C 2 . ? 28.469 129.633 74.911 1.00 27.92 ? 911 NAG M C3 1 HETATM 4043 C C4 . NAG C 2 . ? 27.499 128.692 74.205 1.00 27.47 ? 911 NAG M C4 1 HETATM 4044 C C5 . NAG C 2 . ? 28.268 127.496 73.655 1.00 27.48 ? 911 NAG M C5 1 HETATM 4045 C C6 . NAG C 2 . ? 27.383 126.510 72.915 1.00 27.65 ? 911 NAG M C6 1 HETATM 4046 C C7 . NAG C 2 . ? 31.037 131.942 74.165 1.00 27.32 ? 911 NAG M C7 1 HETATM 4047 C C8 . NAG C 2 . ? 31.676 132.931 75.127 1.00 27.52 ? 911 NAG M C8 1 HETATM 4048 N N2 . NAG C 2 . ? 30.595 130.796 74.674 1.00 24.68 ? 911 NAG M N2 1 HETATM 4049 O O3 . NAG C 2 . ? 27.778 130.804 75.328 1.00 28.03 ? 911 NAG M O3 1 HETATM 4050 O O4 . NAG C 2 . ? 26.509 128.247 75.122 1.00 32.59 ? 911 NAG M O4 1 HETATM 4051 O O5 . NAG C 2 . ? 29.274 127.946 72.729 1.00 24.08 ? 911 NAG M O5 1 HETATM 4052 O O6 . NAG C 2 . ? 26.768 127.109 71.784 1.00 30.57 ? 911 NAG M O6 1 HETATM 4053 O O7 . NAG C 2 . ? 30.931 132.228 72.973 1.00 27.02 ? 911 NAG M O7 1 HETATM 4054 C C1 . NAG D 2 . ? 60.115 101.333 36.420 1.00 18.69 ? 921 NAG M C1 1 HETATM 4055 C C2 . NAG D 2 . ? 61.067 101.500 35.237 1.00 18.65 ? 921 NAG M C2 1 HETATM 4056 C C3 . NAG D 2 . ? 60.462 100.828 34.006 1.00 22.99 ? 921 NAG M C3 1 HETATM 4057 C C4 . NAG D 2 . ? 60.100 99.377 34.317 1.00 25.91 ? 921 NAG M C4 1 HETATM 4058 C C5 . NAG D 2 . ? 59.243 99.294 35.579 1.00 24.30 ? 921 NAG M C5 1 HETATM 4059 C C6 . NAG D 2 . ? 58.973 97.866 36.004 1.00 24.61 ? 921 NAG M C6 1 HETATM 4060 C C7 . NAG D 2 . ? 62.472 103.461 35.217 1.00 19.37 ? 921 NAG M C7 1 HETATM 4061 C C8 . NAG D 2 . ? 62.717 104.845 34.639 1.00 22.77 ? 921 NAG M C8 1 HETATM 4062 N N2 . NAG D 2 . ? 61.289 102.908 34.970 1.00 19.85 ? 921 NAG M N2 1 HETATM 4063 O O3 . NAG D 2 . ? 61.394 100.872 32.937 1.00 22.37 ? 921 NAG M O3 1 HETATM 4064 O O4 . NAG D 2 . ? 59.359 98.822 33.214 1.00 30.38 ? 921 NAG M O4 1 HETATM 4065 O O5 . NAG D 2 . ? 59.908 99.946 36.676 1.00 17.38 ? 921 NAG M O5 1 HETATM 4066 O O6 . NAG D 2 . ? 60.154 97.238 36.480 1.00 27.71 ? 921 NAG M O6 1 HETATM 4067 O O7 . NAG D 2 . ? 63.348 102.907 35.882 1.00 20.35 ? 921 NAG M O7 1 HETATM 4068 C C1 . NAG E 2 . ? 59.872 97.663 32.660 1.00 37.46 ? 923 NAG M C1 1 HETATM 4069 C C2 . NAG E 2 . ? 58.749 96.881 31.978 1.00 38.20 ? 923 NAG M C2 1 HETATM 4070 C C3 . NAG E 2 . ? 59.325 95.646 31.292 1.00 40.42 ? 923 NAG M C3 1 HETATM 4071 C C4 . NAG E 2 . ? 60.442 96.064 30.340 1.00 41.15 ? 923 NAG M C4 1 HETATM 4072 C C5 . NAG E 2 . ? 61.488 96.893 31.088 1.00 41.81 ? 923 NAG M C5 1 HETATM 4073 C C6 . NAG E 2 . ? 62.578 97.418 30.173 1.00 42.23 ? 923 NAG M C6 1 HETATM 4074 C C7 . NAG E 2 . ? 56.491 96.877 32.817 1.00 40.27 ? 923 NAG M C7 1 HETATM 4075 C C8 . NAG E 2 . ? 55.430 95.790 32.742 1.00 41.98 ? 923 NAG M C8 1 HETATM 4076 N N2 . NAG E 2 . ? 57.755 96.488 32.959 1.00 38.49 ? 923 NAG M N2 1 HETATM 4077 O O3 . NAG E 2 . ? 58.300 94.980 30.567 1.00 41.49 ? 923 NAG M O3 1 HETATM 4078 O O4 . NAG E 2 . ? 61.055 94.909 29.784 1.00 42.37 ? 923 NAG M O4 1 HETATM 4079 O O5 . NAG E 2 . ? 60.866 98.038 31.703 1.00 38.99 ? 923 NAG M O5 1 HETATM 4080 O O6 . NAG E 2 . ? 62.029 98.157 29.092 1.00 43.86 ? 923 NAG M O6 1 HETATM 4081 O O7 . NAG E 2 . ? 56.163 98.060 32.719 1.00 40.80 ? 923 NAG M O7 1 HETATM 4082 C C1 . NAG F 2 . ? 45.508 92.308 70.260 1.00 38.28 ? 931 NAG M C1 1 HETATM 4083 C C2 . NAG F 2 . ? 46.144 91.756 68.990 1.00 40.44 ? 931 NAG M C2 1 HETATM 4084 C C3 . NAG F 2 . ? 46.672 90.353 69.261 1.00 42.71 ? 931 NAG M C3 1 HETATM 4085 C C4 . NAG F 2 . ? 47.631 90.386 70.446 1.00 43.03 ? 931 NAG M C4 1 HETATM 4086 C C5 . NAG F 2 . ? 46.938 91.015 71.653 1.00 43.68 ? 931 NAG M C5 1 HETATM 4087 C C6 . NAG F 2 . ? 47.857 91.158 72.849 1.00 44.03 ? 931 NAG M C6 1 HETATM 4088 C C7 . NAG F 2 . ? 45.424 92.338 66.768 1.00 40.81 ? 931 NAG M C7 1 HETATM 4089 C C8 . NAG F 2 . ? 46.841 92.242 66.235 1.00 42.27 ? 931 NAG M C8 1 HETATM 4090 N N2 . NAG F 2 . ? 45.171 91.718 67.915 1.00 41.03 ? 931 NAG M N2 1 HETATM 4091 O O3 . NAG F 2 . ? 47.343 89.861 68.110 1.00 45.19 ? 931 NAG M O3 1 HETATM 4092 O O4 . NAG F 2 . ? 48.042 89.065 70.764 1.00 45.09 ? 931 NAG M O4 1 HETATM 4093 O O5 . NAG F 2 . ? 46.467 92.334 71.318 1.00 41.34 ? 931 NAG M O5 1 HETATM 4094 O O6 . NAG F 2 . ? 49.021 91.902 72.517 1.00 46.53 ? 931 NAG M O6 1 HETATM 4095 O O7 . NAG F 2 . ? 44.565 92.937 66.124 1.00 43.10 ? 931 NAG M O7 1 HETATM 4096 C C1 . NAG G 2 . ? 33.720 121.471 22.802 1.00 18.13 ? 941 NAG M C1 1 HETATM 4097 C C2 . NAG G 2 . ? 34.202 122.587 21.874 1.00 18.21 ? 941 NAG M C2 1 HETATM 4098 C C3 . NAG G 2 . ? 33.423 122.567 20.559 1.00 22.65 ? 941 NAG M C3 1 HETATM 4099 C C4 . NAG G 2 . ? 33.439 121.167 19.958 1.00 21.28 ? 941 NAG M C4 1 HETATM 4100 C C5 . NAG G 2 . ? 32.919 120.178 20.986 1.00 20.41 ? 941 NAG M C5 1 HETATM 4101 C C6 . NAG G 2 . ? 32.880 118.745 20.490 1.00 20.96 ? 941 NAG M C6 1 HETATM 4102 C C7 . NAG G 2 . ? 35.055 124.645 22.800 1.00 17.20 ? 941 NAG M C7 1 HETATM 4103 C C8 . NAG G 2 . ? 34.761 125.982 23.457 1.00 18.45 ? 941 NAG M C8 1 HETATM 4104 N N2 . NAG G 2 . ? 34.012 123.871 22.523 1.00 17.29 ? 941 NAG M N2 1 HETATM 4105 O O3 . NAG G 2 . ? 34.021 123.496 19.638 1.00 26.25 ? 941 NAG M O3 1 HETATM 4106 O O4 . NAG G 2 . ? 32.605 121.131 18.788 1.00 23.84 ? 941 NAG M O4 1 HETATM 4107 O O5 . NAG G 2 . ? 33.769 120.208 22.139 1.00 18.35 ? 941 NAG M O5 1 HETATM 4108 O O6 . NAG G 2 . ? 34.181 118.272 20.178 1.00 21.76 ? 941 NAG M O6 1 HETATM 4109 O O7 . NAG G 2 . ? 36.216 124.322 22.558 1.00 19.64 ? 941 NAG M O7 1 HETATM 4110 C C1 . FUC H 3 . ? 33.386 124.739 19.570 1.00 30.22 ? 942 FUC M C1 1 HETATM 4111 C C2 . FUC H 3 . ? 34.299 125.743 18.871 1.00 33.14 ? 942 FUC M C2 1 HETATM 4112 C C3 . FUC H 3 . ? 34.482 125.337 17.413 1.00 35.51 ? 942 FUC M C3 1 HETATM 4113 C C4 . FUC H 3 . ? 33.114 125.241 16.743 1.00 35.23 ? 942 FUC M C4 1 HETATM 4114 C C5 . FUC H 3 . ? 32.231 124.260 17.517 1.00 33.87 ? 942 FUC M C5 1 HETATM 4115 C C6 . FUC H 3 . ? 30.817 124.185 16.971 1.00 32.47 ? 942 FUC M C6 1 HETATM 4116 O O2 . FUC H 3 . ? 35.561 125.782 19.522 1.00 36.50 ? 942 FUC M O2 1 HETATM 4117 O O3 . FUC H 3 . ? 35.285 126.298 16.743 1.00 38.40 ? 942 FUC M O3 1 HETATM 4118 O O4 . FUC H 3 . ? 32.502 126.523 16.723 1.00 36.27 ? 942 FUC M O4 1 HETATM 4119 O O5 . FUC H 3 . ? 32.136 124.665 18.898 1.00 30.69 ? 942 FUC M O5 1 HETATM 4120 C C1 . NAG I 2 . ? 33.177 120.550 17.671 1.00 29.72 ? 943 NAG M C1 1 HETATM 4121 C C2 . NAG I 2 . ? 32.105 120.316 16.613 1.00 30.06 ? 943 NAG M C2 1 HETATM 4122 C C3 . NAG I 2 . ? 32.743 119.741 15.354 1.00 34.54 ? 943 NAG M C3 1 HETATM 4123 C C4 . NAG I 2 . ? 33.880 120.643 14.885 1.00 35.75 ? 943 NAG M C4 1 HETATM 4124 C C5 . NAG I 2 . ? 34.864 120.904 16.028 1.00 36.01 ? 943 NAG M C5 1 HETATM 4125 C C6 . NAG I 2 . ? 35.932 121.909 15.644 1.00 37.08 ? 943 NAG M C6 1 HETATM 4126 C C7 . NAG I 2 . ? 29.864 119.821 17.344 1.00 29.71 ? 943 NAG M C7 1 HETATM 4127 C C8 . NAG I 2 . ? 28.776 118.763 17.408 1.00 30.44 ? 943 NAG M C8 1 HETATM 4128 N N2 . NAG I 2 . ? 31.107 119.400 17.129 1.00 28.66 ? 943 NAG M N2 1 HETATM 4129 O O3 . NAG I 2 . ? 31.764 119.639 14.331 1.00 34.26 ? 943 NAG M O3 1 HETATM 4130 O O4 . NAG I 2 . ? 34.575 120.007 13.797 1.00 40.39 ? 943 NAG M O4 1 HETATM 4131 O O5 . NAG I 2 . ? 34.173 121.444 17.171 1.00 33.17 ? 943 NAG M O5 1 HETATM 4132 O O6 . NAG I 2 . ? 37.020 121.875 16.556 1.00 39.59 ? 943 NAG M O6 1 HETATM 4133 O O7 . NAG I 2 . ? 29.573 121.010 17.476 1.00 31.24 ? 943 NAG M O7 1 HETATM 4134 C C1 . BMA J 4 . ? 34.889 120.804 12.708 1.00 45.42 ? 944 BMA M C1 1 HETATM 4135 C C2 . BMA J 4 . ? 35.985 120.129 11.889 1.00 47.75 ? 944 BMA M C2 1 HETATM 4136 C C3 . BMA J 4 . ? 36.279 120.949 10.636 1.00 48.61 ? 944 BMA M C3 1 HETATM 4137 C C4 . BMA J 4 . ? 34.990 121.166 9.851 1.00 48.86 ? 944 BMA M C4 1 HETATM 4138 C C5 . BMA J 4 . ? 33.929 121.791 10.758 1.00 48.53 ? 944 BMA M C5 1 HETATM 4139 C C6 . BMA J 4 . ? 32.591 121.961 10.064 1.00 48.89 ? 944 BMA M C6 1 HETATM 4140 O O2 . BMA J 4 . ? 35.560 118.804 11.520 1.00 49.85 ? 944 BMA M O2 1 HETATM 4141 O O3 . BMA J 4 . ? 37.230 120.272 9.828 1.00 49.70 ? 944 BMA M O3 1 HETATM 4142 O O4 . BMA J 4 . ? 35.243 122.022 8.746 1.00 49.58 ? 944 BMA M O4 1 HETATM 4143 O O5 . BMA J 4 . ? 33.708 120.955 11.913 1.00 46.36 ? 944 BMA M O5 1 HETATM 4144 O O6 . BMA J 4 . ? 32.188 120.760 9.421 1.00 50.54 ? 944 BMA M O6 1 HETATM 4145 C C1B . XYP K 5 . ? 36.126 117.766 12.241 1.00 51.90 ? 945 XYP M C1B 1 HETATM 4146 C C2B . XYP K 5 . ? 35.336 116.480 11.997 1.00 52.48 ? 945 XYP M C2B 1 HETATM 4147 C C3B . XYP K 5 . ? 36.019 115.301 12.687 1.00 53.07 ? 945 XYP M C3B 1 HETATM 4148 C C4B . XYP K 5 . ? 37.479 115.224 12.251 1.00 53.12 ? 945 XYP M C4B 1 HETATM 4149 C C5B . XYP K 5 . ? 38.165 116.562 12.510 1.00 52.75 ? 945 XYP M C5B 1 HETATM 4150 O O2B . XYP K 5 . ? 34.019 116.629 12.506 1.00 53.31 ? 945 XYP M O2B 1 HETATM 4151 O O3B . XYP K 5 . ? 35.352 114.094 12.347 1.00 52.86 ? 945 XYP M O3B 1 HETATM 4152 O O4B . XYP K 5 . ? 38.144 114.196 12.972 1.00 53.62 ? 945 XYP M O4B 1 HETATM 4153 O O5B . XYP K 5 . ? 37.479 117.611 11.803 1.00 52.41 ? 945 XYP M O5B 1 HETATM 4154 C C1 . NAG L 2 . ? 34.058 94.738 43.848 1.00 19.90 ? 951 NAG M C1 1 HETATM 4155 C C2 . NAG L 2 . ? 34.143 95.192 42.390 1.00 19.65 ? 951 NAG M C2 1 HETATM 4156 C C3 . NAG L 2 . ? 33.732 94.080 41.431 1.00 21.40 ? 951 NAG M C3 1 HETATM 4157 C C4 . NAG L 2 . ? 34.476 92.801 41.764 1.00 22.58 ? 951 NAG M C4 1 HETATM 4158 C C5 . NAG L 2 . ? 34.283 92.451 43.227 1.00 23.15 ? 951 NAG M C5 1 HETATM 4159 C C6 . NAG L 2 . ? 35.043 91.200 43.618 1.00 25.31 ? 951 NAG M C6 1 HETATM 4160 C C7 . NAG L 2 . ? 33.793 97.555 42.043 1.00 25.40 ? 951 NAG M C7 1 HETATM 4161 C C8 . NAG L 2 . ? 32.856 98.728 42.281 1.00 25.75 ? 951 NAG M C8 1 HETATM 4162 N N2 . NAG L 2 . ? 33.278 96.338 42.185 1.00 20.45 ? 951 NAG M N2 1 HETATM 4163 O O3 . NAG L 2 . ? 34.058 94.478 40.090 1.00 20.51 ? 951 NAG M O3 1 HETATM 4164 O O4 . NAG L 2 . ? 33.995 91.723 40.944 1.00 23.94 ? 951 NAG M O4 1 HETATM 4165 O O5 . NAG L 2 . ? 34.781 93.522 44.044 1.00 20.56 ? 951 NAG M O5 1 HETATM 4166 O O6 . NAG L 2 . ? 34.824 90.874 44.982 1.00 26.42 ? 951 NAG M O6 1 HETATM 4167 O O7 . NAG L 2 . ? 34.970 97.758 41.739 1.00 23.10 ? 951 NAG M O7 1 HETATM 4168 C C1 . FUC M 3 . ? 33.003 95.018 39.353 1.00 25.98 ? 952 FUC M C1 1 HETATM 4169 C C2 . FUC M 3 . ? 33.565 95.718 38.117 1.00 27.18 ? 952 FUC M C2 1 HETATM 4170 C C3 . FUC M 3 . ? 34.200 94.684 37.189 1.00 26.99 ? 952 FUC M C3 1 HETATM 4171 C C4 . FUC M 3 . ? 33.178 93.606 36.846 1.00 29.09 ? 952 FUC M C4 1 HETATM 4172 C C5 . FUC M 3 . ? 32.636 92.990 38.131 1.00 28.70 ? 952 FUC M C5 1 HETATM 4173 C C6 . FUC M 3 . ? 31.547 91.967 37.876 1.00 31.47 ? 952 FUC M C6 1 HETATM 4174 O O2 . FUC M 3 . ? 34.543 96.671 38.512 1.00 26.05 ? 952 FUC M O2 1 HETATM 4175 O O3 . FUC M 3 . ? 34.647 95.316 36.001 1.00 26.99 ? 952 FUC M O3 1 HETATM 4176 O O4 . FUC M 3 . ? 32.112 94.185 36.107 1.00 30.33 ? 952 FUC M O4 1 HETATM 4177 O O5 . FUC M 3 . ? 32.071 94.021 38.962 1.00 25.62 ? 952 FUC M O5 1 HETATM 4178 C C1 . NAG N 2 . ? 34.989 90.984 40.336 1.00 27.95 ? 953 NAG M C1 1 HETATM 4179 C C2 . NAG N 2 . ? 34.447 89.631 39.892 1.00 29.86 ? 953 NAG M C2 1 HETATM 4180 C C3 . NAG N 2 . ? 35.541 88.856 39.167 1.00 32.55 ? 953 NAG M C3 1 HETATM 4181 C C4 . NAG N 2 . ? 36.229 89.702 38.091 1.00 33.24 ? 953 NAG M C4 1 HETATM 4182 C C5 . NAG N 2 . ? 36.593 91.092 38.610 1.00 30.35 ? 953 NAG M C5 1 HETATM 4183 C C6 . NAG N 2 . ? 37.079 92.011 37.509 1.00 30.01 ? 953 NAG M C6 1 HETATM 4184 C C7 . NAG N 2 . ? 32.730 88.831 41.391 1.00 31.45 ? 953 NAG M C7 1 HETATM 4185 C C8 . NAG N 2 . ? 32.404 88.289 42.773 1.00 32.36 ? 953 NAG M C8 1 HETATM 4186 N N2 . NAG N 2 . ? 34.014 88.869 41.049 1.00 31.10 ? 953 NAG M N2 1 HETATM 4187 O O3 . NAG N 2 . ? 34.977 87.700 38.565 1.00 31.51 ? 953 NAG M O3 1 HETATM 4188 O O4 . NAG N 2 . ? 37.440 89.044 37.694 1.00 36.87 ? 953 NAG M O4 1 HETATM 4189 O O5 . NAG N 2 . ? 35.449 91.715 39.205 1.00 26.04 ? 953 NAG M O5 1 HETATM 4190 O O6 . NAG N 2 . ? 37.804 93.106 38.045 1.00 24.09 ? 953 NAG M O6 1 HETATM 4191 O O7 . NAG N 2 . ? 31.823 89.216 40.653 1.00 33.00 ? 953 NAG M O7 1 HETATM 4192 C C1 . BMA O 4 . ? 37.568 88.713 36.361 1.00 43.43 ? 954 BMA M C1 1 HETATM 4193 C C2 . BMA O 4 . ? 39.052 88.628 36.027 1.00 45.42 ? 954 BMA M C2 1 HETATM 4194 C C3 . BMA O 4 . ? 39.237 88.159 34.597 1.00 46.89 ? 954 BMA M C3 1 HETATM 4195 C C4 . BMA O 4 . ? 38.525 86.824 34.417 1.00 47.06 ? 954 BMA M C4 1 HETATM 4196 C C5 . BMA O 4 . ? 37.052 86.947 34.828 1.00 47.33 ? 954 BMA M C5 1 HETATM 4197 C C6 . BMA O 4 . ? 36.336 85.609 34.804 1.00 48.63 ? 954 BMA M C6 1 HETATM 4198 O O2 . BMA O 4 . ? 39.689 87.703 36.926 1.00 46.85 ? 954 BMA M O2 1 HETATM 4199 O O3 . BMA O 4 . ? 40.643 88.008 34.323 1.00 47.63 ? 954 BMA M O3 1 HETATM 4200 O O4 . BMA O 4 . ? 38.615 86.418 33.060 1.00 47.08 ? 954 BMA M O4 1 HETATM 4201 O O5 . BMA O 4 . ? 36.947 87.438 36.178 1.00 43.63 ? 954 BMA M O5 1 HETATM 4202 O O6 . BMA O 4 . ? 36.939 84.729 35.771 1.00 51.27 ? 954 BMA M O6 1 HETATM 4203 C C1B . XYP P 5 . ? 40.631 88.238 37.789 1.00 49.12 ? 955 XYP M C1B 1 HETATM 4204 C C2B . XYP P 5 . ? 40.734 87.364 39.035 1.00 49.97 ? 955 XYP M C2B 1 HETATM 4205 C C3B . XYP P 5 . ? 41.832 87.892 39.952 1.00 51.02 ? 955 XYP M C3B 1 HETATM 4206 C C4B . XYP P 5 . ? 43.140 87.989 39.175 1.00 51.00 ? 955 XYP M C4B 1 HETATM 4207 C C5B . XYP P 5 . ? 42.936 88.836 37.920 1.00 50.43 ? 955 XYP M C5B 1 HETATM 4208 O O2B . XYP P 5 . ? 39.492 87.366 39.723 1.00 49.65 ? 955 XYP M O2B 1 HETATM 4209 O O3B . XYP P 5 . ? 41.993 87.019 41.061 1.00 52.61 ? 955 XYP M O3B 1 HETATM 4210 O O4B . XYP P 5 . ? 44.142 88.576 39.993 1.00 52.75 ? 955 XYP M O4B 1 HETATM 4211 O O5B . XYP P 5 . ? 41.888 88.272 37.107 1.00 49.84 ? 955 XYP M O5B 1 HETATM 4212 C C1 . MAN Q 6 . ? 41.154 88.824 33.309 1.00 49.08 ? 956 MAN M C1 1 HETATM 4213 C C2 . MAN Q 6 . ? 42.629 88.501 33.086 1.00 49.76 ? 956 MAN M C2 1 HETATM 4214 C C3 . MAN Q 6 . ? 43.434 88.905 34.317 1.00 50.20 ? 956 MAN M C3 1 HETATM 4215 C C4 . MAN Q 6 . ? 43.208 90.383 34.611 1.00 49.99 ? 956 MAN M C4 1 HETATM 4216 C C5 . MAN Q 6 . ? 41.712 90.666 34.761 1.00 49.46 ? 956 MAN M C5 1 HETATM 4217 C C6 . MAN Q 6 . ? 41.428 92.150 34.905 1.00 48.48 ? 956 MAN M C6 1 HETATM 4218 O O2 . MAN Q 6 . ? 43.105 89.206 31.949 1.00 49.46 ? 956 MAN M O2 1 HETATM 4219 O O3 . MAN Q 6 . ? 44.816 88.665 34.090 1.00 50.06 ? 956 MAN M O3 1 HETATM 4220 O O4 . MAN Q 6 . ? 43.887 90.743 35.805 1.00 49.57 ? 956 MAN M O4 1 HETATM 4221 O O5 . MAN Q 6 . ? 40.996 90.209 33.595 1.00 49.12 ? 956 MAN M O5 1 HETATM 4222 O O6 . MAN Q 6 . ? 40.182 92.376 35.548 1.00 43.24 ? 956 MAN M O6 1 HETATM 4223 C C1 . MAN R 6 . ? 36.166 83.590 36.022 1.00 53.59 ? 957 MAN M C1 1 HETATM 4224 C C2 . MAN R 6 . ? 36.830 82.764 37.119 1.00 55.00 ? 957 MAN M C2 1 HETATM 4225 C C3 . MAN R 6 . ? 38.185 82.273 36.622 1.00 55.63 ? 957 MAN M C3 1 HETATM 4226 C C4 . MAN R 6 . ? 38.006 81.480 35.331 1.00 55.85 ? 957 MAN M C4 1 HETATM 4227 C C5 . MAN R 6 . ? 37.228 82.297 34.294 1.00 55.80 ? 957 MAN M C5 1 HETATM 4228 C C6 . MAN R 6 . ? 36.853 81.469 33.080 1.00 55.35 ? 957 MAN M C6 1 HETATM 4229 O O2 . MAN R 6 . ? 36.007 81.654 37.451 1.00 55.21 ? 957 MAN M O2 1 HETATM 4230 O O3 . MAN R 6 . ? 38.791 81.453 37.611 1.00 56.84 ? 957 MAN M O3 1 HETATM 4231 O O4 . MAN R 6 . ? 39.281 81.140 34.805 1.00 56.95 ? 957 MAN M O4 1 HETATM 4232 O O5 . MAN R 6 . ? 35.997 82.790 34.861 1.00 54.78 ? 957 MAN M O5 1 HETATM 4233 O O6 . MAN R 6 . ? 37.953 81.323 32.196 1.00 55.82 ? 957 MAN M O6 1 HETATM 4234 C C1 . NAG S 2 . ? 68.190 122.950 43.023 1.00 83.30 ? 961 NAG M C1 1 HETATM 4235 C C2 . NAG S 2 . ? 68.240 123.209 41.517 1.00 83.11 ? 961 NAG M C2 1 HETATM 4236 C C3 . NAG S 2 . ? 68.003 121.908 40.752 1.00 83.09 ? 961 NAG M C3 1 HETATM 4237 C C4 . NAG S 2 . ? 68.978 120.836 41.231 1.00 83.04 ? 961 NAG M C4 1 HETATM 4238 C C5 . NAG S 2 . ? 68.878 120.687 42.747 1.00 82.82 ? 961 NAG M C5 1 HETATM 4239 C C6 . NAG S 2 . ? 69.869 119.684 43.306 1.00 82.81 ? 961 NAG M C6 1 HETATM 4240 C C7 . NAG S 2 . ? 67.584 125.313 40.546 1.00 82.89 ? 961 NAG M C7 1 HETATM 4241 C C8 . NAG S 2 . ? 67.595 125.310 39.025 1.00 82.76 ? 961 NAG M C8 1 HETATM 4242 N N2 . NAG S 2 . ? 67.230 124.185 41.153 1.00 82.96 ? 961 NAG M N2 1 HETATM 4243 O O1 . NAG S 2 . ? 68.507 124.112 43.708 1.00 83.78 ? 961 NAG M O1 1 HETATM 4244 O O3 . NAG S 2 . ? 68.182 122.131 39.361 1.00 83.24 ? 961 NAG M O3 1 HETATM 4245 O O4 . NAG S 2 . ? 68.675 119.597 40.605 1.00 83.09 ? 961 NAG M O4 1 HETATM 4246 O O5 . NAG S 2 . ? 69.147 121.950 43.384 1.00 83.10 ? 961 NAG M O5 1 HETATM 4247 O O6 . NAG S 2 . ? 69.465 119.223 44.587 1.00 82.35 ? 961 NAG M O6 1 HETATM 4248 O O7 . NAG S 2 . ? 67.893 126.335 41.160 1.00 82.63 ? 961 NAG M O7 1 HETATM 4249 C C1 . NAG T 2 . ? 59.175 113.939 29.311 1.00 50.78 ? 971 NAG M C1 1 HETATM 4250 C C2 . NAG T 2 . ? 58.670 114.234 27.896 1.00 53.71 ? 971 NAG M C2 1 HETATM 4251 C C3 . NAG T 2 . ? 58.264 115.703 27.784 1.00 54.66 ? 971 NAG M C3 1 HETATM 4252 C C4 . NAG T 2 . ? 57.273 116.063 28.887 1.00 55.31 ? 971 NAG M C4 1 HETATM 4253 C C5 . NAG T 2 . ? 57.848 115.680 30.248 1.00 54.39 ? 971 NAG M C5 1 HETATM 4254 C C6 . NAG T 2 . ? 56.880 115.936 31.386 1.00 55.34 ? 971 NAG M C6 1 HETATM 4255 C C7 . NAG T 2 . ? 59.552 112.937 26.067 1.00 56.25 ? 971 NAG M C7 1 HETATM 4256 C C8 . NAG T 2 . ? 60.501 111.758 26.203 1.00 56.64 ? 971 NAG M C8 1 HETATM 4257 N N2 . NAG T 2 . ? 59.705 113.942 26.923 1.00 55.55 ? 971 NAG M N2 1 HETATM 4258 O O3 . NAG T 2 . ? 57.674 115.942 26.514 1.00 55.59 ? 971 NAG M O3 1 HETATM 4259 O O4 . NAG T 2 . ? 57.007 117.459 28.855 1.00 56.67 ? 971 NAG M O4 1 HETATM 4260 O O5 . NAG T 2 . ? 58.167 114.276 30.269 1.00 53.76 ? 971 NAG M O5 1 HETATM 4261 O O6 . NAG T 2 . ? 55.662 115.230 31.196 1.00 55.95 ? 971 NAG M O6 1 HETATM 4262 O O7 . NAG T 2 . ? 58.681 112.927 25.196 1.00 57.38 ? 971 NAG M O7 1 HETATM 4263 C C1 . NAG U 2 . ? 32.744 126.654 30.569 1.00 10.54 ? 981 NAG M C1 1 HETATM 4264 C C2 . NAG U 2 . ? 31.737 125.957 29.646 1.00 11.87 ? 981 NAG M C2 1 HETATM 4265 C C3 . NAG U 2 . ? 30.520 126.855 29.409 1.00 14.56 ? 981 NAG M C3 1 HETATM 4266 C C4 . NAG U 2 . ? 29.951 127.359 30.729 1.00 15.36 ? 981 NAG M C4 1 HETATM 4267 C C5 . NAG U 2 . ? 31.056 127.961 31.617 1.00 13.84 ? 981 NAG M C5 1 HETATM 4268 C C6 . NAG U 2 . ? 30.566 128.329 33.003 1.00 14.84 ? 981 NAG M C6 1 HETATM 4269 C C7 . NAG U 2 . ? 32.500 124.373 27.981 1.00 14.59 ? 981 NAG M C7 1 HETATM 4270 C C8 . NAG U 2 . ? 32.961 124.144 26.552 1.00 15.20 ? 981 NAG M C8 1 HETATM 4271 N N2 . NAG U 2 . ? 32.369 125.638 28.377 1.00 10.49 ? 981 NAG M N2 1 HETATM 4272 O O3 . NAG U 2 . ? 29.511 126.109 28.736 1.00 15.71 ? 981 NAG M O3 1 HETATM 4273 O O4 . NAG U 2 . ? 28.945 128.351 30.461 1.00 15.74 ? 981 NAG M O4 1 HETATM 4274 O O5 . NAG U 2 . ? 32.113 126.997 31.797 1.00 11.37 ? 981 NAG M O5 1 HETATM 4275 O O6 . NAG U 2 . ? 30.085 127.190 33.704 1.00 18.99 ? 981 NAG M O6 1 HETATM 4276 O O7 . NAG U 2 . ? 32.262 123.408 28.709 1.00 14.12 ? 981 NAG M O7 1 HETATM 4277 C C1 . NAG V 2 . ? 27.641 128.054 30.852 1.00 22.40 ? 983 NAG M C1 1 HETATM 4278 C C2 . NAG V 2 . ? 26.823 129.327 30.907 1.00 23.84 ? 983 NAG M C2 1 HETATM 4279 C C3 . NAG V 2 . ? 25.337 129.059 31.100 1.00 27.32 ? 983 NAG M C3 1 HETATM 4280 C C4 . NAG V 2 . ? 24.867 128.069 30.082 1.00 29.50 ? 983 NAG M C4 1 HETATM 4281 C C5 . NAG V 2 . ? 25.712 126.825 30.223 1.00 29.59 ? 983 NAG M C5 1 HETATM 4282 C C6 . NAG V 2 . ? 25.272 125.755 29.258 1.00 33.40 ? 983 NAG M C6 1 HETATM 4283 C C7 . NAG V 2 . ? 28.071 131.124 31.758 1.00 24.78 ? 983 NAG M C7 1 HETATM 4284 C C8 . NAG V 2 . ? 28.621 131.899 32.944 1.00 28.18 ? 983 NAG M C8 1 HETATM 4285 N N2 . NAG V 2 . ? 27.255 130.125 32.016 1.00 25.51 ? 983 NAG M N2 1 HETATM 4286 O O3 . NAG V 2 . ? 24.625 130.273 30.933 1.00 29.88 ? 983 NAG M O3 1 HETATM 4287 O O4 . NAG V 2 . ? 23.497 127.769 30.303 1.00 34.32 ? 983 NAG M O4 1 HETATM 4288 O O5 . NAG V 2 . ? 27.104 127.129 29.923 1.00 28.22 ? 983 NAG M O5 1 HETATM 4289 O O6 . NAG V 2 . ? 25.380 126.202 27.917 1.00 36.16 ? 983 NAG M O6 1 HETATM 4290 O O7 . NAG V 2 . ? 28.384 131.437 30.613 1.00 28.99 ? 983 NAG M O7 1 HETATM 4291 C C1 . NAG W 2 . ? 57.702 137.993 72.383 1.00 55.84 ? 991 NAG M C1 1 HETATM 4292 C C2 . NAG W 2 . ? 58.279 139.154 73.196 1.00 57.69 ? 991 NAG M C2 1 HETATM 4293 C C3 . NAG W 2 . ? 57.761 139.101 74.632 1.00 58.11 ? 991 NAG M C3 1 HETATM 4294 C C4 . NAG W 2 . ? 56.236 139.034 74.635 1.00 58.06 ? 991 NAG M C4 1 HETATM 4295 C C5 . NAG W 2 . ? 55.772 137.863 73.773 1.00 57.84 ? 991 NAG M C5 1 HETATM 4296 C C6 . NAG W 2 . ? 54.261 137.760 73.681 1.00 57.29 ? 991 NAG M C6 1 HETATM 4297 C C7 . NAG W 2 . ? 60.440 139.944 72.475 1.00 60.04 ? 991 NAG M C7 1 HETATM 4298 C C8 . NAG W 2 . ? 60.909 139.481 71.105 1.00 59.93 ? 991 NAG M C8 1 HETATM 4299 N N2 . NAG W 2 . ? 59.729 139.083 73.197 1.00 59.17 ? 991 NAG M N2 1 HETATM 4300 O O3 . NAG W 2 . ? 58.192 140.256 75.339 1.00 58.14 ? 991 NAG M O3 1 HETATM 4301 O O4 . NAG W 2 . ? 55.764 138.870 75.965 1.00 57.87 ? 991 NAG M O4 1 HETATM 4302 O O5 . NAG W 2 . ? 56.272 138.014 72.433 1.00 56.91 ? 991 NAG M O5 1 HETATM 4303 O O6 . NAG W 2 . ? 53.712 138.864 72.975 1.00 57.30 ? 991 NAG M O6 1 HETATM 4304 O O7 . NAG W 2 . ? 60.722 141.076 72.871 1.00 60.63 ? 991 NAG M O7 1 HETATM 4305 C C1 . CGT X 7 . ? 48.012 120.509 50.792 0.48 35.87 ? 999 CGT M C1 1 HETATM 4306 S S1 . CGT X 7 . ? 48.110 119.052 49.722 0.63 34.87 ? 999 CGT M S1 1 HETATM 4307 C C2 . CGT X 7 . ? 47.657 120.077 52.209 0.48 36.46 ? 999 CGT M C2 1 HETATM 4308 O O2 . CGT X 7 . ? 46.433 119.361 52.192 0.48 35.30 ? 999 CGT M O2 1 HETATM 4309 C C3 . CGT X 7 . ? 47.511 121.302 53.102 0.48 37.34 ? 999 CGT M C3 1 HETATM 4310 O O3 . CGT X 7 . ? 47.294 120.889 54.444 0.48 36.58 ? 999 CGT M O3 1 HETATM 4311 C C4 . CGT X 7 . ? 48.761 122.176 53.039 0.48 37.77 ? 999 CGT M C4 1 HETATM 4312 O O4 . CGT X 7 . ? 48.504 123.386 53.733 0.48 39.38 ? 999 CGT M O4 1 HETATM 4313 C C5 . CGT X 7 . ? 49.150 122.498 51.592 0.48 37.42 ? 999 CGT M C5 1 HETATM 4314 C C7 . CGT X 7 . ? 49.325 121.223 50.821 0.48 36.59 ? 999 CGT M C7 1 HETATM 4315 C C6 . CGT X 7 . ? 50.435 123.298 51.504 0.48 37.31 ? 999 CGT M C6 1 HETATM 4316 O O6 . CGT X 7 . ? 51.424 122.780 52.380 0.48 38.47 ? 999 CGT M O6 1 HETATM 4317 C CB . CGT X 7 . ? 45.685 120.320 48.739 0.63 30.25 ? 999 CGT M CB 1 HETATM 4318 C CG . CGT X 7 . ? 46.338 121.584 48.250 0.63 27.67 ? 999 CGT M CG 1 HETATM 4319 C CD1 . CGT X 7 . ? 46.150 122.784 48.931 0.63 26.57 ? 999 CGT M CD1 1 HETATM 4320 C CD2 . CGT X 7 . ? 47.135 121.580 47.109 0.63 27.56 ? 999 CGT M CD2 1 HETATM 4321 C CE1 . CGT X 7 . ? 46.744 123.958 48.482 0.63 26.46 ? 999 CGT M CE1 1 HETATM 4322 C CE2 . CGT X 7 . ? 47.734 122.750 46.651 0.63 26.75 ? 999 CGT M CE2 1 HETATM 4323 C CZ . CGT X 7 . ? 47.539 123.940 47.338 0.63 26.99 ? 999 CGT M CZ 1 HETATM 4324 C C13 . CGT X 7 . ? 46.681 119.181 48.736 0.63 31.99 ? 999 CGT M C13 1 HETATM 4325 N N17 . CGT X 7 . ? 46.361 118.269 47.900 0.63 30.36 ? 999 CGT M N17 1 HETATM 4326 O O18 . CGT X 7 . ? 47.309 117.194 47.908 0.63 29.45 ? 999 CGT M O18 1 HETATM 4327 S S19 . CGT X 7 . ? 47.417 116.591 46.544 0.63 26.27 ? 999 CGT M S19 1 HETATM 4328 O O20 . CGT X 7 . ? 48.176 117.581 45.753 0.63 27.49 ? 999 CGT M O20 1 HETATM 4329 O O21 . CGT X 7 . ? 48.134 115.326 46.752 0.63 24.59 ? 999 CGT M O21 1 HETATM 4330 O O22 . CGT X 7 . ? 46.019 116.413 46.093 0.63 27.04 ? 999 CGT M O22 1 HETATM 4331 C C1 . GOL Y 8 . ? 48.853 121.013 53.980 0.37 14.75 ? 1000 GOL M C1 1 HETATM 4332 O O1 . GOL Y 8 . ? 49.261 122.166 54.722 0.37 15.67 ? 1000 GOL M O1 1 HETATM 4333 C C2 . GOL Y 8 . ? 48.233 119.978 54.961 0.37 12.59 ? 1000 GOL M C2 1 HETATM 4334 O O2 . GOL Y 8 . ? 49.318 119.424 55.717 0.37 13.06 ? 1000 GOL M O2 1 HETATM 4335 C C3 . GOL Y 8 . ? 47.765 118.850 54.017 0.37 12.69 ? 1000 GOL M C3 1 HETATM 4336 O O3 . GOL Y 8 . ? 47.247 117.749 54.779 0.37 9.34 ? 1000 GOL M O3 1 HETATM 4337 ZN ZN . ZN Z 9 . ? 67.626 121.999 60.481 0.50 8.33 ? 1502 ZN M ZN 1 HETATM 4338 S S . SO4 AA 10 . ? 66.393 101.545 45.946 1.00 34.19 ? 1503 SO4 M S 1 HETATM 4339 O O1 . SO4 AA 10 . ? 65.472 101.519 44.796 1.00 37.92 ? 1503 SO4 M O1 1 HETATM 4340 O O2 . SO4 AA 10 . ? 66.763 100.165 46.308 1.00 37.48 ? 1503 SO4 M O2 1 HETATM 4341 O O3 . SO4 AA 10 . ? 65.739 102.195 47.095 1.00 36.74 ? 1503 SO4 M O3 1 HETATM 4342 O O4 . SO4 AA 10 . ? 67.609 102.298 45.585 1.00 39.45 ? 1503 SO4 M O4 1 HETATM 4343 S S . SO4 BA 10 . ? 65.755 95.617 65.597 1.00 44.67 ? 1504 SO4 M S 1 HETATM 4344 O O1 . SO4 BA 10 . ? 64.578 94.776 65.891 1.00 43.52 ? 1504 SO4 M O1 1 HETATM 4345 O O2 . SO4 BA 10 . ? 65.770 96.782 66.503 1.00 40.80 ? 1504 SO4 M O2 1 HETATM 4346 O O3 . SO4 BA 10 . ? 65.688 96.080 64.197 1.00 43.45 ? 1504 SO4 M O3 1 HETATM 4347 O O4 . SO4 BA 10 . ? 66.985 94.824 65.793 1.00 44.51 ? 1504 SO4 M O4 1 HETATM 4348 S S . SO4 CA 10 . ? 47.550 118.397 40.014 1.00 67.61 ? 1505 SO4 M S 1 HETATM 4349 O O1 . SO4 CA 10 . ? 47.089 117.105 40.560 1.00 67.05 ? 1505 SO4 M O1 1 HETATM 4350 O O2 . SO4 CA 10 . ? 47.625 119.394 41.099 1.00 67.19 ? 1505 SO4 M O2 1 HETATM 4351 O O3 . SO4 CA 10 . ? 46.600 118.863 38.987 1.00 67.02 ? 1505 SO4 M O3 1 HETATM 4352 O O4 . SO4 CA 10 . ? 48.885 118.225 39.409 1.00 67.59 ? 1505 SO4 M O4 1 HETATM 4353 S S . SO4 DA 10 . ? 26.512 133.546 42.233 1.00 21.58 ? 1506 SO4 M S 1 HETATM 4354 O O1 . SO4 DA 10 . ? 26.422 132.084 42.391 1.00 20.74 ? 1506 SO4 M O1 1 HETATM 4355 O O2 . SO4 DA 10 . ? 25.342 134.184 42.869 1.00 24.13 ? 1506 SO4 M O2 1 HETATM 4356 O O3 . SO4 DA 10 . ? 26.533 133.883 40.799 1.00 25.64 ? 1506 SO4 M O3 1 HETATM 4357 O O4 . SO4 DA 10 . ? 27.742 134.046 42.872 1.00 22.06 ? 1506 SO4 M O4 1 HETATM 4358 C C1 . GOL EA 8 . ? 64.651 111.561 52.501 1.00 24.65 ? 1512 GOL M C1 1 HETATM 4359 O O1 . GOL EA 8 . ? 64.565 112.816 51.489 1.00 18.49 ? 1512 GOL M O1 1 HETATM 4360 C C2 . GOL EA 8 . ? 65.548 110.482 52.401 1.00 28.08 ? 1512 GOL M C2 1 HETATM 4361 O O2 . GOL EA 8 . ? 64.949 109.315 52.625 1.00 25.78 ? 1512 GOL M O2 1 HETATM 4362 C C3 . GOL EA 8 . ? 66.655 110.886 52.169 1.00 30.67 ? 1512 GOL M C3 1 HETATM 4363 O O3 . GOL EA 8 . ? 67.829 111.853 51.881 1.00 34.44 ? 1512 GOL M O3 1 HETATM 4364 C C1 . GOL FA 8 . ? 33.447 104.331 76.405 1.00 30.33 ? 1513 GOL M C1 1 HETATM 4365 O O1 . GOL FA 8 . ? 33.606 105.796 77.055 1.00 28.15 ? 1513 GOL M O1 1 HETATM 4366 C C2 . GOL FA 8 . ? 32.256 103.608 76.283 1.00 33.71 ? 1513 GOL M C2 1 HETATM 4367 O O2 . GOL FA 8 . ? 31.285 104.112 77.061 1.00 20.54 ? 1513 GOL M O2 1 HETATM 4368 C C3 . GOL FA 8 . ? 32.419 102.702 75.503 1.00 32.67 ? 1513 GOL M C3 1 HETATM 4369 O O3 . GOL FA 8 . ? 33.115 101.748 74.489 1.00 40.59 ? 1513 GOL M O3 1 HETATM 4370 O O . HOH GA 11 . ? 24.536 132.696 51.592 1.00 42.57 ? 2001 HOH M O 1 HETATM 4371 O O . HOH GA 11 . ? 24.741 122.612 44.668 1.00 52.72 ? 2002 HOH M O 1 HETATM 4372 O O . HOH GA 11 . ? 19.947 130.811 51.441 1.00 42.61 ? 2003 HOH M O 1 HETATM 4373 O O . HOH GA 11 . ? 23.447 133.304 48.816 1.00 52.46 ? 2004 HOH M O 1 HETATM 4374 O O . HOH GA 11 . ? 26.576 140.643 46.686 1.00 50.00 ? 2005 HOH M O 1 HETATM 4375 O O . HOH GA 11 . ? 23.674 124.792 43.144 1.00 38.67 ? 2006 HOH M O 1 HETATM 4376 O O . HOH GA 11 . ? 26.414 132.758 36.609 1.00 38.31 ? 2007 HOH M O 1 HETATM 4377 O O . HOH GA 11 . ? 28.828 140.461 53.977 1.00 24.31 ? 2008 HOH M O 1 HETATM 4378 O O . HOH GA 11 . ? 23.442 125.766 70.829 1.00 46.11 ? 2009 HOH M O 1 HETATM 4379 O O . HOH GA 11 . ? 22.834 127.676 45.370 1.00 26.89 ? 2010 HOH M O 1 HETATM 4380 O O . HOH GA 11 . ? 37.150 135.837 40.620 1.00 11.45 ? 2011 HOH M O 1 HETATM 4381 O O . HOH GA 11 . ? 27.065 132.082 49.803 1.00 21.28 ? 2012 HOH M O 1 HETATM 4382 O O . HOH GA 11 . ? 28.614 129.778 48.829 1.00 11.63 ? 2013 HOH M O 1 HETATM 4383 O O . HOH GA 11 . ? 25.888 137.808 45.659 1.00 37.41 ? 2014 HOH M O 1 HETATM 4384 O O . HOH GA 11 . ? 30.661 140.935 56.720 1.00 69.04 ? 2015 HOH M O 1 HETATM 4385 O O . HOH GA 11 . ? 33.333 139.411 62.750 1.00 67.84 ? 2016 HOH M O 1 HETATM 4386 O O . HOH GA 11 . ? 24.537 127.548 42.863 1.00 38.43 ? 2017 HOH M O 1 HETATM 4387 O O . HOH GA 11 . ? 32.935 128.893 41.588 1.00 11.55 ? 2018 HOH M O 1 HETATM 4388 O O . HOH GA 11 . ? 28.057 125.433 38.957 1.00 45.38 ? 2019 HOH M O 1 HETATM 4389 O O . HOH GA 11 . ? 28.305 141.381 58.959 1.00 38.10 ? 2020 HOH M O 1 HETATM 4390 O O . HOH GA 11 . ? 31.248 130.630 37.788 1.00 21.00 ? 2021 HOH M O 1 HETATM 4391 O O . HOH GA 11 . ? 28.188 130.934 38.177 1.00 44.63 ? 2022 HOH M O 1 HETATM 4392 O O . HOH GA 11 . ? 34.013 133.059 39.646 1.00 19.07 ? 2023 HOH M O 1 HETATM 4393 O O . HOH GA 11 . ? 23.019 124.972 67.378 1.00 48.24 ? 2024 HOH M O 1 HETATM 4394 O O . HOH GA 11 . ? 28.691 137.882 41.544 1.00 19.76 ? 2025 HOH M O 1 HETATM 4395 O O . HOH GA 11 . ? 32.986 137.200 40.300 0.50 11.57 ? 2026 HOH M O 1 HETATM 4396 O O . HOH GA 11 . ? 34.602 135.187 41.268 1.00 11.40 ? 2027 HOH M O 1 HETATM 4397 O O . HOH GA 11 . ? 32.449 139.828 51.543 1.00 71.64 ? 2028 HOH M O 1 HETATM 4398 O O . HOH GA 11 . ? 33.197 138.895 48.705 1.00 17.64 ? 2029 HOH M O 1 HETATM 4399 O O . HOH GA 11 . ? 28.273 112.309 67.366 1.00 64.46 ? 2030 HOH M O 1 HETATM 4400 O O . HOH GA 11 . ? 54.798 129.874 77.719 1.00 45.78 ? 2031 HOH M O 1 HETATM 4401 O O . HOH GA 11 . ? 22.924 138.632 50.420 1.00 67.00 ? 2032 HOH M O 1 HETATM 4402 O O . HOH GA 11 . ? 24.474 135.679 52.655 1.00 83.70 ? 2033 HOH M O 1 HETATM 4403 O O . HOH GA 11 . ? 28.934 133.739 58.283 1.00 18.31 ? 2034 HOH M O 1 HETATM 4404 O O . HOH GA 11 . ? 32.144 139.029 59.452 1.00 63.10 ? 2035 HOH M O 1 HETATM 4405 O O . HOH GA 11 . ? 31.278 137.113 52.619 1.00 24.14 ? 2036 HOH M O 1 HETATM 4406 O O . HOH GA 11 . ? 24.801 140.809 53.602 1.00 47.77 ? 2037 HOH M O 1 HETATM 4407 O O . HOH GA 11 . ? 28.768 139.055 60.849 1.00 30.11 ? 2038 HOH M O 1 HETATM 4408 O O . HOH GA 11 . ? 57.843 96.182 72.409 1.00 41.13 ? 2039 HOH M O 1 HETATM 4409 O O . HOH GA 11 . ? 21.774 141.190 58.539 1.00 48.48 ? 2040 HOH M O 1 HETATM 4410 O O . HOH GA 11 . ? 22.890 130.426 54.329 1.00 51.83 ? 2041 HOH M O 1 HETATM 4411 O O . HOH GA 11 . ? 20.320 132.646 55.223 1.00 50.38 ? 2042 HOH M O 1 HETATM 4412 O O . HOH GA 11 . ? 39.853 122.426 84.038 1.00 68.87 ? 2043 HOH M O 1 HETATM 4413 O O . HOH GA 11 . ? 68.155 124.261 54.694 1.00 25.17 ? 2044 HOH M O 1 HETATM 4414 O O . HOH GA 11 . ? 25.009 127.394 67.410 1.00 38.70 ? 2045 HOH M O 1 HETATM 4415 O O . HOH GA 11 . ? 72.905 118.665 45.855 1.00 40.44 ? 2046 HOH M O 1 HETATM 4416 O O . HOH GA 11 . ? 54.700 95.424 45.036 1.00 39.84 ? 2047 HOH M O 1 HETATM 4417 O O . HOH GA 11 . ? 59.013 96.028 43.306 1.00 43.41 ? 2048 HOH M O 1 HETATM 4418 O O . HOH GA 11 . ? 21.179 131.448 66.350 1.00 37.76 ? 2049 HOH M O 1 HETATM 4419 O O . HOH GA 11 . ? 60.397 120.286 40.959 1.00 64.38 ? 2050 HOH M O 1 HETATM 4420 O O . HOH GA 11 . ? 63.035 119.696 38.896 1.00 89.24 ? 2051 HOH M O 1 HETATM 4421 O O . HOH GA 11 . ? 61.154 127.566 43.483 1.00 59.14 ? 2052 HOH M O 1 HETATM 4422 O O . HOH GA 11 . ? 60.241 121.273 44.004 1.00 30.84 ? 2053 HOH M O 1 HETATM 4423 O O . HOH GA 11 . ? 59.036 134.793 56.557 1.00 63.06 ? 2054 HOH M O 1 HETATM 4424 O O . HOH GA 11 . ? 63.277 134.312 54.555 1.00 62.74 ? 2055 HOH M O 1 HETATM 4425 O O . HOH GA 11 . ? 60.723 132.891 58.334 1.00 39.04 ? 2056 HOH M O 1 HETATM 4426 O O . HOH GA 11 . ? 64.273 130.241 56.799 1.00 49.80 ? 2057 HOH M O 1 HETATM 4427 O O . HOH GA 11 . ? 69.254 129.563 54.018 1.00 71.78 ? 2058 HOH M O 1 HETATM 4428 O O . HOH GA 11 . ? 68.800 126.722 56.281 1.00 57.28 ? 2059 HOH M O 1 HETATM 4429 O O . HOH GA 11 . ? 22.117 115.812 59.954 1.00 56.93 ? 2060 HOH M O 1 HETATM 4430 O O . HOH GA 11 . ? 20.039 121.470 61.427 1.00 54.59 ? 2061 HOH M O 1 HETATM 4431 O O . HOH GA 11 . ? 19.426 118.435 62.646 1.00 45.75 ? 2062 HOH M O 1 HETATM 4432 O O . HOH GA 11 . ? 24.260 119.906 60.141 1.00 15.73 ? 2063 HOH M O 1 HETATM 4433 O O . HOH GA 11 . ? 25.148 123.606 65.165 1.00 26.64 ? 2064 HOH M O 1 HETATM 4434 O O . HOH GA 11 . ? 19.739 120.188 65.716 1.00 39.57 ? 2065 HOH M O 1 HETATM 4435 O O . HOH GA 11 . ? 63.470 125.326 69.220 1.00 75.57 ? 2066 HOH M O 1 HETATM 4436 O O . HOH GA 11 . ? 59.688 130.883 60.194 1.00 29.19 ? 2067 HOH M O 1 HETATM 4437 O O . HOH GA 11 . ? 61.182 130.426 67.268 1.00 28.40 ? 2068 HOH M O 1 HETATM 4438 O O . HOH GA 11 . ? 28.670 115.635 68.704 1.00 65.20 ? 2069 HOH M O 1 HETATM 4439 O O . HOH GA 11 . ? 28.907 116.045 65.391 1.00 24.63 ? 2070 HOH M O 1 HETATM 4440 O O . HOH GA 11 . ? 29.168 119.921 69.036 1.00 65.41 ? 2071 HOH M O 1 HETATM 4441 O O . HOH GA 11 . ? 26.340 116.639 63.505 1.00 55.42 ? 2072 HOH M O 1 HETATM 4442 O O . HOH GA 11 . ? 56.283 119.045 77.322 1.00 43.68 ? 2073 HOH M O 1 HETATM 4443 O O . HOH GA 11 . ? 58.743 123.203 77.608 1.00 74.98 ? 2074 HOH M O 1 HETATM 4444 O O . HOH GA 11 . ? 27.681 123.508 66.370 1.00 27.04 ? 2075 HOH M O 1 HETATM 4445 O O . HOH GA 11 . ? 52.324 125.483 78.994 1.00 31.84 ? 2076 HOH M O 1 HETATM 4446 O O . HOH GA 11 . ? 52.350 128.780 76.289 1.00 40.98 ? 2077 HOH M O 1 HETATM 4447 O O . HOH GA 11 . ? 51.287 129.633 79.152 1.00 58.85 ? 2078 HOH M O 1 HETATM 4448 O O . HOH GA 11 . ? 53.077 116.605 59.857 1.00 7.98 ? 2079 HOH M O 1 HETATM 4449 O O . HOH GA 11 . ? 29.869 120.813 33.861 1.00 31.96 ? 2080 HOH M O 1 HETATM 4450 O O . HOH GA 11 . ? 58.570 120.188 63.124 1.00 10.51 ? 2081 HOH M O 1 HETATM 4451 O O . HOH GA 11 . ? 60.485 116.664 76.033 1.00 39.96 ? 2082 HOH M O 1 HETATM 4452 O O . HOH GA 11 . ? 51.037 118.113 66.990 1.00 9.34 ? 2083 HOH M O 1 HETATM 4453 O O . HOH GA 11 . ? 56.943 117.562 64.843 1.00 8.09 ? 2084 HOH M O 1 HETATM 4454 O O . HOH GA 11 . ? 66.864 97.565 70.693 1.00 31.83 ? 2085 HOH M O 1 HETATM 4455 O O . HOH GA 11 . ? 56.622 96.247 69.655 1.00 39.69 ? 2086 HOH M O 1 HETATM 4456 O O . HOH GA 11 . ? 63.806 101.719 76.655 1.00 48.73 ? 2087 HOH M O 1 HETATM 4457 O O . HOH GA 11 . ? 64.529 106.533 71.497 1.00 15.00 ? 2088 HOH M O 1 HETATM 4458 O O . HOH GA 11 . ? 65.491 122.645 64.541 1.00 29.53 ? 2089 HOH M O 1 HETATM 4459 O O . HOH GA 11 . ? 58.389 101.626 77.852 1.00 49.97 ? 2090 HOH M O 1 HETATM 4460 O O . HOH GA 11 . ? 63.223 108.121 80.604 1.00 68.37 ? 2091 HOH M O 1 HETATM 4461 O O . HOH GA 11 . ? 59.330 118.197 78.518 1.00 66.50 ? 2092 HOH M O 1 HETATM 4462 O O . HOH GA 11 . ? 53.587 118.496 79.083 1.00 72.55 ? 2093 HOH M O 1 HETATM 4463 O O . HOH GA 11 . ? 47.809 112.367 81.587 1.00 46.11 ? 2094 HOH M O 1 HETATM 4464 O O . HOH GA 11 . ? 49.603 120.816 81.931 1.00 54.04 ? 2095 HOH M O 1 HETATM 4465 O O . HOH GA 11 . ? 52.571 110.754 23.989 1.00 38.11 ? 2096 HOH M O 1 HETATM 4466 O O . HOH GA 11 . ? 64.805 103.569 32.096 1.00 40.87 ? 2097 HOH M O 1 HETATM 4467 O O . HOH GA 11 . ? 47.782 125.227 32.179 1.00 64.90 ? 2098 HOH M O 1 HETATM 4468 O O . HOH GA 11 . ? 66.211 110.338 64.777 1.00 15.26 ? 2099 HOH M O 1 HETATM 4469 O O . HOH GA 11 . ? 40.588 113.972 80.090 1.00 56.49 ? 2100 HOH M O 1 HETATM 4470 O O . HOH GA 11 . ? 40.945 124.005 81.504 1.00 73.74 ? 2101 HOH M O 1 HETATM 4471 O O . HOH GA 11 . ? 37.804 120.048 83.454 1.00 73.54 ? 2102 HOH M O 1 HETATM 4472 O O . HOH GA 11 . ? 31.541 115.918 73.556 1.00 45.99 ? 2103 HOH M O 1 HETATM 4473 O O . HOH GA 11 . ? 33.465 112.245 71.887 1.00 36.64 ? 2104 HOH M O 1 HETATM 4474 O O . HOH GA 11 . ? 36.059 113.257 72.453 1.00 31.93 ? 2105 HOH M O 1 HETATM 4475 O O . HOH GA 11 . ? 62.936 120.042 59.780 1.00 8.85 ? 2106 HOH M O 1 HETATM 4476 O O . HOH GA 11 . ? 68.846 114.752 54.762 1.00 14.32 ? 2107 HOH M O 1 HETATM 4477 O O . HOH GA 11 . ? 55.716 108.086 53.755 1.00 8.54 ? 2108 HOH M O 1 HETATM 4478 O O . HOH GA 11 . ? 65.407 123.597 54.305 1.00 16.28 ? 2109 HOH M O 1 HETATM 4479 O O . HOH GA 11 . ? 69.860 122.401 53.113 1.00 25.88 ? 2110 HOH M O 1 HETATM 4480 O O . HOH GA 11 . ? 70.353 117.906 46.954 1.00 20.89 ? 2111 HOH M O 1 HETATM 4481 O O . HOH GA 11 . ? 68.884 108.168 50.701 1.00 12.45 ? 2112 HOH M O 1 HETATM 4482 O O . HOH GA 11 . ? 71.164 114.767 47.085 1.00 20.33 ? 2113 HOH M O 1 HETATM 4483 O O . HOH GA 11 . ? 71.662 108.679 47.870 1.00 10.75 ? 2114 HOH M O 1 HETATM 4484 O O . HOH GA 11 . ? 56.943 95.301 47.506 1.00 58.69 ? 2115 HOH M O 1 HETATM 4485 O O . HOH GA 11 . ? 60.606 98.176 45.203 1.00 31.49 ? 2116 HOH M O 1 HETATM 4486 O O . HOH GA 11 . ? 62.161 123.704 43.691 1.00 55.82 ? 2117 HOH M O 1 HETATM 4487 O O . HOH GA 11 . ? 59.943 124.972 46.364 1.00 51.73 ? 2118 HOH M O 1 HETATM 4488 O O . HOH GA 11 . ? 66.488 119.539 44.381 1.00 37.08 ? 2119 HOH M O 1 HETATM 4489 O O . HOH GA 11 . ? 63.352 121.579 41.743 1.00 75.84 ? 2120 HOH M O 1 HETATM 4490 O O . HOH GA 11 . ? 68.518 121.538 46.518 1.00 39.40 ? 2121 HOH M O 1 HETATM 4491 O O . HOH GA 11 . ? 63.642 126.934 45.580 1.00 63.31 ? 2122 HOH M O 1 HETATM 4492 O O . HOH GA 11 . ? 54.502 91.317 55.212 1.00 61.84 ? 2123 HOH M O 1 HETATM 4493 O O . HOH GA 11 . ? 57.412 92.353 55.497 1.00 42.65 ? 2124 HOH M O 1 HETATM 4494 O O . HOH GA 11 . ? 64.223 114.498 45.716 1.00 10.75 ? 2125 HOH M O 1 HETATM 4495 O O . HOH GA 11 . ? 48.983 93.808 68.972 1.00 47.07 ? 2126 HOH M O 1 HETATM 4496 O O . HOH GA 11 . ? 43.608 108.677 80.534 1.00 63.58 ? 2127 HOH M O 1 HETATM 4497 O O . HOH GA 11 . ? 61.331 133.673 48.708 1.00 44.17 ? 2128 HOH M O 1 HETATM 4498 O O . HOH GA 11 . ? 66.606 131.183 49.475 1.00 57.41 ? 2129 HOH M O 1 HETATM 4499 O O . HOH GA 11 . ? 59.881 133.552 53.650 1.00 42.70 ? 2130 HOH M O 1 HETATM 4500 O O . HOH GA 11 . ? 61.780 131.712 55.722 1.00 58.06 ? 2131 HOH M O 1 HETATM 4501 O O . HOH GA 11 . ? 66.154 127.977 55.840 1.00 60.28 ? 2132 HOH M O 1 HETATM 4502 O O . HOH GA 11 . ? 71.130 127.638 49.823 1.00 45.93 ? 2133 HOH M O 1 HETATM 4503 O O . HOH GA 11 . ? 69.213 126.700 52.547 1.00 35.41 ? 2134 HOH M O 1 HETATM 4504 O O . HOH GA 11 . ? 32.803 109.500 71.094 1.00 41.10 ? 2135 HOH M O 1 HETATM 4505 O O . HOH GA 11 . ? 63.074 127.571 58.298 1.00 16.83 ? 2136 HOH M O 1 HETATM 4506 O O . HOH GA 11 . ? 65.142 126.347 59.906 1.00 29.05 ? 2137 HOH M O 1 HETATM 4507 O O . HOH GA 11 . ? 61.407 126.405 61.181 1.00 15.70 ? 2138 HOH M O 1 HETATM 4508 O O . HOH GA 11 . ? 62.722 123.137 67.385 1.00 15.17 ? 2139 HOH M O 1 HETATM 4509 O O . HOH GA 11 . ? 67.762 125.222 62.399 1.00 22.28 ? 2140 HOH M O 1 HETATM 4510 O O . HOH GA 11 . ? 54.758 124.878 43.502 1.00 95.45 ? 2141 HOH M O 1 HETATM 4511 O O . HOH GA 11 . ? 62.051 129.104 60.670 1.00 26.00 ? 2142 HOH M O 1 HETATM 4512 O O . HOH GA 11 . ? 64.496 127.742 62.447 1.00 30.34 ? 2143 HOH M O 1 HETATM 4513 O O . HOH GA 11 . ? 56.009 114.981 37.844 1.00 34.64 ? 2144 HOH M O 1 HETATM 4514 O O . HOH GA 11 . ? 56.435 118.944 38.912 1.00 46.97 ? 2145 HOH M O 1 HETATM 4515 O O . HOH GA 11 . ? 60.420 129.638 64.418 1.00 20.29 ? 2146 HOH M O 1 HETATM 4516 O O . HOH GA 11 . ? 60.099 130.072 70.103 1.00 28.33 ? 2147 HOH M O 1 HETATM 4517 O O . HOH GA 11 . ? 60.057 124.609 67.930 1.00 35.78 ? 2148 HOH M O 1 HETATM 4518 O O . HOH GA 11 . ? 68.305 106.669 40.212 1.00 37.37 ? 2149 HOH M O 1 HETATM 4519 O O . HOH GA 11 . ? 50.377 126.280 66.356 1.00 39.63 ? 2150 HOH M O 1 HETATM 4520 O O . HOH GA 11 . ? 71.343 115.014 34.552 1.00 69.04 ? 2151 HOH M O 1 HETATM 4521 O O . HOH GA 11 . ? 56.370 121.799 76.209 1.00 53.28 ? 2152 HOH M O 1 HETATM 4522 O O . HOH GA 11 . ? 62.168 125.929 72.508 1.00 57.26 ? 2153 HOH M O 1 HETATM 4523 O O . HOH GA 11 . ? 60.560 128.303 73.546 1.00 41.18 ? 2154 HOH M O 1 HETATM 4524 O O . HOH GA 11 . ? 56.238 125.605 77.766 1.00 56.04 ? 2155 HOH M O 1 HETATM 4525 O O . HOH GA 11 . ? 52.414 125.790 76.109 1.00 23.99 ? 2156 HOH M O 1 HETATM 4526 O O . HOH GA 11 . ? 60.684 124.585 75.537 1.00 53.17 ? 2157 HOH M O 1 HETATM 4527 O O . HOH GA 11 . ? 69.506 110.359 38.506 1.00 35.61 ? 2158 HOH M O 1 HETATM 4528 O O . HOH GA 11 . ? 64.107 98.780 36.340 1.00 76.52 ? 2159 HOH M O 1 HETATM 4529 O O . HOH GA 11 . ? 54.654 122.954 78.910 1.00 33.37 ? 2160 HOH M O 1 HETATM 4530 O O . HOH GA 11 . ? 58.450 97.135 40.598 1.00 29.95 ? 2161 HOH M O 1 HETATM 4531 O O . HOH GA 11 . ? 49.619 125.099 80.285 1.00 31.56 ? 2162 HOH M O 1 HETATM 4532 O O . HOH GA 11 . ? 43.586 126.362 78.896 1.00 39.66 ? 2163 HOH M O 1 HETATM 4533 O O . HOH GA 11 . ? 46.115 122.959 79.624 1.00 32.09 ? 2164 HOH M O 1 HETATM 4534 O O . HOH GA 11 . ? 46.714 131.934 72.049 1.00 27.19 ? 2165 HOH M O 1 HETATM 4535 O O . HOH GA 11 . ? 50.128 134.713 74.413 1.00 48.49 ? 2166 HOH M O 1 HETATM 4536 O O . HOH GA 11 . ? 48.867 134.435 77.585 1.00 57.47 ? 2167 HOH M O 1 HETATM 4537 O O . HOH GA 11 . ? 52.144 92.647 50.056 1.00 53.15 ? 2168 HOH M O 1 HETATM 4538 O O . HOH GA 11 . ? 52.449 94.510 46.659 1.00 39.68 ? 2169 HOH M O 1 HETATM 4539 O O . HOH GA 11 . ? 48.439 131.059 77.995 1.00 43.83 ? 2170 HOH M O 1 HETATM 4540 O O . HOH GA 11 . ? 41.385 131.805 75.371 1.00 36.82 ? 2171 HOH M O 1 HETATM 4541 O O . HOH GA 11 . ? 42.420 128.066 76.818 1.00 32.16 ? 2172 HOH M O 1 HETATM 4542 O O . HOH GA 11 . ? 47.388 133.046 74.891 1.00 51.00 ? 2173 HOH M O 1 HETATM 4543 O O . HOH GA 11 . ? 45.693 130.049 79.313 1.00 49.14 ? 2174 HOH M O 1 HETATM 4544 O O . HOH GA 11 . ? 35.273 128.059 74.899 1.00 44.02 ? 2175 HOH M O 1 HETATM 4545 O O . HOH GA 11 . ? 37.982 137.028 71.883 1.00 49.17 ? 2176 HOH M O 1 HETATM 4546 O O . HOH GA 11 . ? 35.039 132.283 73.172 1.00 29.21 ? 2177 HOH M O 1 HETATM 4547 O O . HOH GA 11 . ? 43.956 133.429 72.615 1.00 38.30 ? 2178 HOH M O 1 HETATM 4548 O O . HOH GA 11 . ? 41.378 93.571 74.621 1.00 82.12 ? 2179 HOH M O 1 HETATM 4549 O O . HOH GA 11 . ? 27.776 105.901 62.494 1.00 66.18 ? 2180 HOH M O 1 HETATM 4550 O O . HOH GA 11 . ? 27.651 109.138 64.602 1.00 39.21 ? 2181 HOH M O 1 HETATM 4551 O O . HOH GA 11 . ? 31.779 126.673 75.708 1.00 88.67 ? 2182 HOH M O 1 HETATM 4552 O O . HOH GA 11 . ? 36.435 125.829 73.025 1.00 26.00 ? 2183 HOH M O 1 HETATM 4553 O O . HOH GA 11 . ? 29.950 122.663 67.879 1.00 79.03 ? 2184 HOH M O 1 HETATM 4554 O O . HOH GA 11 . ? 32.450 124.861 67.684 1.00 67.69 ? 2185 HOH M O 1 HETATM 4555 O O . HOH GA 11 . ? 27.930 114.755 37.675 1.00 45.60 ? 2186 HOH M O 1 HETATM 4556 O O . HOH GA 11 . ? 29.842 116.382 34.524 1.00 75.40 ? 2187 HOH M O 1 HETATM 4557 O O . HOH GA 11 . ? 31.360 122.900 33.409 1.00 25.47 ? 2188 HOH M O 1 HETATM 4558 O O . HOH GA 11 . ? 48.577 121.911 68.955 1.00 11.37 ? 2189 HOH M O 1 HETATM 4559 O O . HOH GA 11 . ? 48.066 124.533 65.517 1.00 20.72 ? 2190 HOH M O 1 HETATM 4560 O O . HOH GA 11 . ? 26.317 119.222 21.839 1.00 48.68 ? 2191 HOH M O 1 HETATM 4561 O O . HOH GA 11 . ? 40.786 118.708 24.082 1.00 51.79 ? 2192 HOH M O 1 HETATM 4562 O O . HOH GA 11 . ? 34.905 110.416 14.532 1.00 48.29 ? 2193 HOH M O 1 HETATM 4563 O O . HOH GA 11 . ? 49.489 118.785 64.713 1.00 7.27 ? 2194 HOH M O 1 HETATM 4564 O O . HOH GA 11 . ? 28.908 113.839 32.878 1.00 67.93 ? 2195 HOH M O 1 HETATM 4565 O O . HOH GA 11 . ? 42.172 105.083 29.292 1.00 56.04 ? 2196 HOH M O 1 HETATM 4566 O O . HOH GA 11 . ? 36.167 106.001 27.233 1.00 39.75 ? 2197 HOH M O 1 HETATM 4567 O O . HOH GA 11 . ? 39.475 103.780 28.494 1.00 66.37 ? 2198 HOH M O 1 HETATM 4568 O O . HOH GA 11 . ? 27.829 112.897 41.240 1.00 23.83 ? 2199 HOH M O 1 HETATM 4569 O O . HOH GA 11 . ? 34.835 101.311 43.342 1.00 17.41 ? 2200 HOH M O 1 HETATM 4570 O O . HOH GA 11 . ? 58.790 115.611 73.154 1.00 17.30 ? 2201 HOH M O 1 HETATM 4571 O O . HOH GA 11 . ? 34.228 90.159 48.525 1.00 68.28 ? 2202 HOH M O 1 HETATM 4572 O O . HOH GA 11 . ? 40.786 90.295 43.019 1.00 68.03 ? 2203 HOH M O 1 HETATM 4573 O O . HOH GA 11 . ? 40.467 93.084 41.584 1.00 24.23 ? 2204 HOH M O 1 HETATM 4574 O O . HOH GA 11 . ? 62.665 109.599 64.280 1.00 13.79 ? 2205 HOH M O 1 HETATM 4575 O O . HOH GA 11 . ? 69.599 98.502 69.439 1.00 40.57 ? 2206 HOH M O 1 HETATM 4576 O O . HOH GA 11 . ? 39.335 93.247 30.528 1.00 71.22 ? 2207 HOH M O 1 HETATM 4577 O O . HOH GA 11 . ? 41.754 98.033 28.445 1.00 56.34 ? 2208 HOH M O 1 HETATM 4578 O O . HOH GA 11 . ? 39.377 96.203 28.848 1.00 60.45 ? 2209 HOH M O 1 HETATM 4579 O O . HOH GA 11 . ? 56.877 100.939 65.672 1.00 12.39 ? 2210 HOH M O 1 HETATM 4580 O O . HOH GA 11 . ? 45.348 93.659 39.200 1.00 43.49 ? 2211 HOH M O 1 HETATM 4581 O O . HOH GA 11 . ? 55.678 97.073 39.893 1.00 30.63 ? 2212 HOH M O 1 HETATM 4582 O O . HOH GA 11 . ? 48.644 91.957 36.375 1.00 47.42 ? 2213 HOH M O 1 HETATM 4583 O O . HOH GA 11 . ? 59.014 99.747 73.791 1.00 28.51 ? 2214 HOH M O 1 HETATM 4584 O O . HOH GA 11 . ? 56.421 99.993 74.077 1.00 25.20 ? 2215 HOH M O 1 HETATM 4585 O O . HOH GA 11 . ? 53.515 96.557 69.925 1.00 76.47 ? 2216 HOH M O 1 HETATM 4586 O O . HOH GA 11 . ? 46.913 87.032 45.807 1.00 53.94 ? 2217 HOH M O 1 HETATM 4587 O O . HOH GA 11 . ? 53.057 90.481 47.691 1.00 80.10 ? 2218 HOH M O 1 HETATM 4588 O O . HOH GA 11 . ? 38.874 88.309 47.083 1.00 48.70 ? 2219 HOH M O 1 HETATM 4589 O O . HOH GA 11 . ? 63.103 98.977 74.686 1.00 59.89 ? 2220 HOH M O 1 HETATM 4590 O O . HOH GA 11 . ? 58.636 96.807 67.510 1.00 20.67 ? 2221 HOH M O 1 HETATM 4591 O O . HOH GA 11 . ? 64.553 96.140 68.916 1.00 25.93 ? 2222 HOH M O 1 HETATM 4592 O O . HOH GA 11 . ? 62.110 95.656 73.419 1.00 52.34 ? 2223 HOH M O 1 HETATM 4593 O O . HOH GA 11 . ? 47.925 93.514 55.862 1.00 51.36 ? 2224 HOH M O 1 HETATM 4594 O O . HOH GA 11 . ? 41.161 85.979 55.762 1.00 67.65 ? 2225 HOH M O 1 HETATM 4595 O O . HOH GA 11 . ? 52.476 92.376 53.027 1.00 44.83 ? 2226 HOH M O 1 HETATM 4596 O O . HOH GA 11 . ? 65.124 104.165 72.891 1.00 26.29 ? 2227 HOH M O 1 HETATM 4597 O O . HOH GA 11 . ? 62.574 105.119 69.996 1.00 13.75 ? 2228 HOH M O 1 HETATM 4598 O O . HOH GA 11 . ? 30.381 102.744 57.587 1.00 44.94 ? 2229 HOH M O 1 HETATM 4599 O O . HOH GA 11 . ? 60.993 102.520 76.230 1.00 24.34 ? 2230 HOH M O 1 HETATM 4600 O O . HOH GA 11 . ? 63.668 104.884 75.227 1.00 22.96 ? 2231 HOH M O 1 HETATM 4601 O O . HOH GA 11 . ? 61.089 104.879 77.986 1.00 30.56 ? 2232 HOH M O 1 HETATM 4602 O O . HOH GA 11 . ? 27.918 105.352 59.174 1.00 27.04 ? 2233 HOH M O 1 HETATM 4603 O O . HOH GA 11 . ? 61.170 114.367 74.311 1.00 30.81 ? 2234 HOH M O 1 HETATM 4604 O O . HOH GA 11 . ? 63.514 111.211 76.211 1.00 22.40 ? 2235 HOH M O 1 HETATM 4605 O O . HOH GA 11 . ? 58.630 104.278 79.735 1.00 58.48 ? 2236 HOH M O 1 HETATM 4606 O O . HOH GA 11 . ? 61.778 107.636 77.546 1.00 13.92 ? 2237 HOH M O 1 HETATM 4607 O O . HOH GA 11 . ? 56.707 116.235 78.401 1.00 52.51 ? 2238 HOH M O 1 HETATM 4608 O O . HOH GA 11 . ? 57.582 116.924 75.647 1.00 74.45 ? 2239 HOH M O 1 HETATM 4609 O O . HOH GA 11 . ? 61.840 110.427 78.776 1.00 58.84 ? 2240 HOH M O 1 HETATM 4610 O O . HOH GA 11 . ? 44.197 126.944 27.426 1.00 76.53 ? 2241 HOH M O 1 HETATM 4611 O O . HOH GA 11 . ? 49.266 116.106 24.044 1.00 53.46 ? 2242 HOH M O 1 HETATM 4612 O O . HOH GA 11 . ? 54.469 109.565 79.027 1.00 57.89 ? 2243 HOH M O 1 HETATM 4613 O O . HOH GA 11 . ? 51.968 112.539 82.724 1.00 44.22 ? 2244 HOH M O 1 HETATM 4614 O O . HOH GA 11 . ? 51.411 115.172 80.704 1.00 59.55 ? 2245 HOH M O 1 HETATM 4615 O O . HOH GA 11 . ? 51.384 107.885 24.138 1.00 59.79 ? 2246 HOH M O 1 HETATM 4616 O O . HOH GA 11 . ? 51.889 119.305 76.308 1.00 31.22 ? 2247 HOH M O 1 HETATM 4617 O O . HOH GA 11 . ? 50.648 120.026 68.946 1.00 13.19 ? 2248 HOH M O 1 HETATM 4618 O O . HOH GA 11 . ? 65.936 106.332 33.124 1.00 28.46 ? 2249 HOH M O 1 HETATM 4619 O O . HOH GA 11 . ? 50.026 114.247 34.996 1.00 56.69 ? 2250 HOH M O 1 HETATM 4620 O O . HOH GA 11 . ? 45.739 111.228 76.847 1.00 33.11 ? 2251 HOH M O 1 HETATM 4621 O O . HOH GA 11 . ? 45.804 113.277 79.014 1.00 62.38 ? 2252 HOH M O 1 HETATM 4622 O O . HOH GA 11 . ? 47.216 120.028 80.115 1.00 22.49 ? 2253 HOH M O 1 HETATM 4623 O O . HOH GA 11 . ? 46.790 124.438 35.641 1.00 43.29 ? 2254 HOH M O 1 HETATM 4624 O O . HOH GA 11 . ? 44.835 126.359 31.687 1.00 34.73 ? 2255 HOH M O 1 HETATM 4625 O O . HOH GA 11 . ? 41.431 116.631 81.008 1.00 47.22 ? 2256 HOH M O 1 HETATM 4626 O O . HOH GA 11 . ? 42.983 123.544 79.064 1.00 22.50 ? 2257 HOH M O 1 HETATM 4627 O O . HOH GA 11 . ? 34.062 132.897 31.754 1.00 59.24 ? 2258 HOH M O 1 HETATM 4628 O O . HOH GA 11 . ? 38.529 135.349 33.551 1.00 19.13 ? 2259 HOH M O 1 HETATM 4629 O O . HOH GA 11 . ? 35.266 119.489 79.573 1.00 42.72 ? 2260 HOH M O 1 HETATM 4630 O O . HOH GA 11 . ? 39.993 135.521 37.381 1.00 25.29 ? 2261 HOH M O 1 HETATM 4631 O O . HOH GA 11 . ? 35.395 121.236 81.968 1.00 47.68 ? 2262 HOH M O 1 HETATM 4632 O O . HOH GA 11 . ? 45.244 121.389 82.270 1.00 89.95 ? 2263 HOH M O 1 HETATM 4633 O O . HOH GA 11 . ? 35.276 123.625 79.506 1.00 49.95 ? 2264 HOH M O 1 HETATM 4634 O O . HOH GA 11 . ? 41.411 137.200 40.300 0.50 21.91 ? 2265 HOH M O 1 HETATM 4635 O O . HOH GA 11 . ? 34.366 125.362 76.776 1.00 54.37 ? 2266 HOH M O 1 HETATM 4636 O O . HOH GA 11 . ? 55.561 128.989 45.415 1.00 74.14 ? 2267 HOH M O 1 HETATM 4637 O O . HOH GA 11 . ? 47.856 136.782 45.804 1.00 39.81 ? 2268 HOH M O 1 HETATM 4638 O O . HOH GA 11 . ? 32.451 115.087 70.834 1.00 35.74 ? 2269 HOH M O 1 HETATM 4639 O O . HOH GA 11 . ? 33.532 118.970 72.096 1.00 23.35 ? 2270 HOH M O 1 HETATM 4640 O O . HOH GA 11 . ? 38.182 112.571 70.621 1.00 10.85 ? 2271 HOH M O 1 HETATM 4641 O O . HOH GA 11 . ? 42.360 136.520 34.925 1.00 52.42 ? 2272 HOH M O 1 HETATM 4642 O O . HOH GA 11 . ? 28.415 121.992 36.292 1.00 50.01 ? 2273 HOH M O 1 HETATM 4643 O O . HOH GA 11 . ? 46.705 116.239 61.221 1.00 9.84 ? 2274 HOH M O 1 HETATM 4644 O O . HOH GA 11 . ? 25.299 113.533 39.505 1.00 50.89 ? 2275 HOH M O 1 HETATM 4645 O O . HOH GA 11 . ? 27.875 109.036 41.696 1.00 59.49 ? 2276 HOH M O 1 HETATM 4646 O O . HOH GA 11 . ? 24.208 102.515 48.558 1.00 49.82 ? 2277 HOH M O 1 HETATM 4647 O O . HOH GA 11 . ? 55.449 110.792 53.933 1.00 9.67 ? 2278 HOH M O 1 HETATM 4648 O O . HOH GA 11 . ? 28.493 99.230 42.007 1.00 79.31 ? 2279 HOH M O 1 HETATM 4649 O O . HOH GA 11 . ? 51.919 113.100 62.149 1.00 6.93 ? 2280 HOH M O 1 HETATM 4650 O O . HOH GA 11 . ? 53.722 110.426 62.326 1.00 7.98 ? 2281 HOH M O 1 HETATM 4651 O O . HOH GA 11 . ? 57.248 115.871 62.611 1.00 8.88 ? 2282 HOH M O 1 HETATM 4652 O O . HOH GA 11 . ? 57.535 112.298 63.050 1.00 8.10 ? 2283 HOH M O 1 HETATM 4653 O O . HOH GA 11 . ? 58.394 137.453 58.516 1.00 64.05 ? 2284 HOH M O 1 HETATM 4654 O O . HOH GA 11 . ? 51.680 139.941 48.584 1.00 36.86 ? 2285 HOH M O 1 HETATM 4655 O O . HOH GA 11 . ? 45.291 136.855 47.426 1.00 74.54 ? 2286 HOH M O 1 HETATM 4656 O O . HOH GA 11 . ? 53.078 138.497 68.131 1.00 73.96 ? 2287 HOH M O 1 HETATM 4657 O O . HOH GA 11 . ? 70.135 108.414 58.519 1.00 12.66 ? 2288 HOH M O 1 HETATM 4658 O O . HOH GA 11 . ? 68.950 108.946 53.485 1.00 19.31 ? 2289 HOH M O 1 HETATM 4659 O O . HOH GA 11 . ? 45.570 144.771 53.493 1.00 64.49 ? 2290 HOH M O 1 HETATM 4660 O O . HOH GA 11 . ? 63.808 96.575 60.689 1.00 47.09 ? 2291 HOH M O 1 HETATM 4661 O O . HOH GA 11 . ? 67.650 97.270 60.450 0.50 27.66 ? 2292 HOH M O 1 HETATM 4662 O O . HOH GA 11 . ? 35.125 141.214 59.121 1.00 35.80 ? 2293 HOH M O 1 HETATM 4663 O O . HOH GA 11 . ? 63.178 99.061 49.688 1.00 40.44 ? 2294 HOH M O 1 HETATM 4664 O O . HOH GA 11 . ? 33.770 140.422 56.467 1.00 29.66 ? 2295 HOH M O 1 HETATM 4665 O O . HOH GA 11 . ? 66.504 106.928 52.046 1.00 13.77 ? 2296 HOH M O 1 HETATM 4666 O O . HOH GA 11 . ? 59.033 97.331 47.373 1.00 25.88 ? 2297 HOH M O 1 HETATM 4667 O O . HOH GA 11 . ? 61.414 96.920 49.081 1.00 37.40 ? 2298 HOH M O 1 HETATM 4668 O O . HOH GA 11 . ? 60.251 93.277 52.815 1.00 33.19 ? 2299 HOH M O 1 HETATM 4669 O O . HOH GA 11 . ? 19.162 118.321 57.792 1.00 52.97 ? 2300 HOH M O 1 HETATM 4670 O O . HOH GA 11 . ? 55.122 94.375 58.028 1.00 14.20 ? 2301 HOH M O 1 HETATM 4671 O O . HOH GA 11 . ? 22.374 111.280 58.328 1.00 50.50 ? 2302 HOH M O 1 HETATM 4672 O O . HOH GA 11 . ? 63.471 95.040 52.621 1.00 41.79 ? 2303 HOH M O 1 HETATM 4673 O O . HOH GA 11 . ? 60.977 96.335 59.602 1.00 51.08 ? 2304 HOH M O 1 HETATM 4674 O O . HOH GA 11 . ? 64.692 94.920 55.271 1.00 38.00 ? 2305 HOH M O 1 HETATM 4675 O O . HOH GA 11 . ? 64.592 96.334 57.836 1.00 37.88 ? 2306 HOH M O 1 HETATM 4676 O O . HOH GA 11 . ? 58.221 95.341 59.965 1.00 21.20 ? 2307 HOH M O 1 HETATM 4677 O O . HOH GA 11 . ? 57.484 92.781 58.773 1.00 30.43 ? 2308 HOH M O 1 HETATM 4678 O O . HOH GA 11 . ? 52.896 92.229 57.852 1.00 53.60 ? 2309 HOH M O 1 HETATM 4679 O O . HOH GA 11 . ? 62.356 98.896 61.647 1.00 21.41 ? 2310 HOH M O 1 HETATM 4680 O O . HOH GA 11 . ? 57.832 95.217 63.220 1.00 48.45 ? 2311 HOH M O 1 HETATM 4681 O O . HOH GA 11 . ? 60.679 96.032 62.453 1.00 50.08 ? 2312 HOH M O 1 HETATM 4682 O O . HOH GA 11 . ? 57.837 133.070 46.672 1.00 53.67 ? 2313 HOH M O 1 HETATM 4683 O O . HOH GA 11 . ? 56.155 93.480 65.283 1.00 73.28 ? 2314 HOH M O 1 HETATM 4684 O O . HOH GA 11 . ? 50.929 95.841 67.923 1.00 37.29 ? 2315 HOH M O 1 HETATM 4685 O O . HOH GA 11 . ? 57.693 97.994 65.197 1.00 23.00 ? 2316 HOH M O 1 HETATM 4686 O O . HOH GA 11 . ? 50.437 95.736 72.819 1.00 37.71 ? 2317 HOH M O 1 HETATM 4687 O O . HOH GA 11 . ? 47.103 95.403 71.034 1.00 29.04 ? 2318 HOH M O 1 HETATM 4688 O O . HOH GA 11 . ? 44.581 105.418 76.894 1.00 21.12 ? 2319 HOH M O 1 HETATM 4689 O O . HOH GA 11 . ? 45.431 101.667 78.031 1.00 44.81 ? 2320 HOH M O 1 HETATM 4690 O O . HOH GA 11 . ? 52.303 107.391 79.911 1.00 38.17 ? 2321 HOH M O 1 HETATM 4691 O O . HOH GA 11 . ? 44.371 108.543 77.435 1.00 28.18 ? 2322 HOH M O 1 HETATM 4692 O O . HOH GA 11 . ? 47.251 106.026 79.525 1.00 42.13 ? 2323 HOH M O 1 HETATM 4693 O O . HOH GA 11 . ? 54.825 103.720 77.270 1.00 44.25 ? 2324 HOH M O 1 HETATM 4694 O O . HOH GA 11 . ? 38.226 104.336 77.186 1.00 37.16 ? 2325 HOH M O 1 HETATM 4695 O O . HOH GA 11 . ? 42.382 101.921 77.252 1.00 28.38 ? 2326 HOH M O 1 HETATM 4696 O O . HOH GA 11 . ? 43.297 112.425 80.700 1.00 67.84 ? 2327 HOH M O 1 HETATM 4697 O O . HOH GA 11 . ? 33.780 108.601 68.551 1.00 20.77 ? 2328 HOH M O 1 HETATM 4698 O O . HOH GA 11 . ? 30.953 109.262 68.013 1.00 63.75 ? 2329 HOH M O 1 HETATM 4699 O O . HOH GA 11 . ? 31.075 113.001 69.507 1.00 50.74 ? 2330 HOH M O 1 HETATM 4700 O O . HOH GA 11 . ? 49.740 110.013 51.592 1.00 11.19 ? 2331 HOH M O 1 HETATM 4701 O O . HOH GA 11 . ? 45.328 111.354 39.476 1.00 32.85 ? 2332 HOH M O 1 HETATM 4702 O O . HOH GA 11 . ? 48.661 114.537 40.609 1.00 44.81 ? 2333 HOH M O 1 HETATM 4703 O O . HOH GA 11 . ? 50.246 114.640 43.056 1.00 24.38 ? 2334 HOH M O 1 HETATM 4704 O O . HOH GA 11 . ? 53.692 122.361 45.181 1.00 46.00 ? 2335 HOH M O 1 HETATM 4705 O O . HOH GA 11 . ? 57.738 106.367 52.943 1.00 7.25 ? 2336 HOH M O 1 HETATM 4706 O O . HOH GA 11 . ? 59.817 106.829 42.904 1.00 9.13 ? 2337 HOH M O 1 HETATM 4707 O O . HOH GA 11 . ? 52.734 115.761 41.984 1.00 21.29 ? 2338 HOH M O 1 HETATM 4708 O O . HOH GA 11 . ? 58.488 116.528 39.040 1.00 35.84 ? 2339 HOH M O 1 HETATM 4709 O O . HOH GA 11 . ? 58.701 120.699 46.583 1.00 17.26 ? 2340 HOH M O 1 HETATM 4710 O O . HOH GA 11 . ? 52.482 118.553 49.923 1.00 27.43 ? 2341 HOH M O 1 HETATM 4711 O O . HOH GA 11 . ? 53.229 113.879 50.681 1.00 10.61 ? 2342 HOH M O 1 HETATM 4712 O O . HOH GA 11 . ? 55.440 113.220 52.326 1.00 7.59 ? 2343 HOH M O 1 HETATM 4713 O O . HOH GA 11 . ? 65.985 108.496 40.449 1.00 13.61 ? 2344 HOH M O 1 HETATM 4714 O O . HOH GA 11 . ? 68.490 111.978 34.544 1.00 52.55 ? 2345 HOH M O 1 HETATM 4715 O O . HOH GA 11 . ? 65.501 119.472 41.222 1.00 65.55 ? 2346 HOH M O 1 HETATM 4716 O O . HOH GA 11 . ? 60.520 117.295 41.796 1.00 21.42 ? 2347 HOH M O 1 HETATM 4717 O O . HOH GA 11 . ? 70.644 112.745 42.450 1.00 33.57 ? 2348 HOH M O 1 HETATM 4718 O O . HOH GA 11 . ? 69.805 113.071 45.472 1.00 19.54 ? 2349 HOH M O 1 HETATM 4719 O O . HOH GA 11 . ? 66.943 111.135 39.886 1.00 15.06 ? 2350 HOH M O 1 HETATM 4720 O O . HOH GA 11 . ? 69.938 105.441 43.056 1.00 35.07 ? 2351 HOH M O 1 HETATM 4721 O O . HOH GA 11 . ? 71.480 108.312 45.059 1.00 15.10 ? 2352 HOH M O 1 HETATM 4722 O O . HOH GA 11 . ? 65.969 104.958 39.392 1.00 35.85 ? 2353 HOH M O 1 HETATM 4723 O O . HOH GA 11 . ? 65.752 103.326 42.259 1.00 20.55 ? 2354 HOH M O 1 HETATM 4724 O O . HOH GA 11 . ? 62.875 100.709 38.841 1.00 33.02 ? 2355 HOH M O 1 HETATM 4725 O O . HOH GA 11 . ? 56.414 102.083 32.943 1.00 44.20 ? 2356 HOH M O 1 HETATM 4726 O O . HOH GA 11 . ? 59.875 99.602 40.618 1.00 19.93 ? 2357 HOH M O 1 HETATM 4727 O O . HOH GA 11 . ? 63.123 101.985 41.799 1.00 28.06 ? 2358 HOH M O 1 HETATM 4728 O O . HOH GA 11 . ? 60.911 100.225 43.347 1.00 23.65 ? 2359 HOH M O 1 HETATM 4729 O O . HOH GA 11 . ? 48.140 101.061 44.333 1.00 7.43 ? 2360 HOH M O 1 HETATM 4730 O O . HOH GA 11 . ? 48.142 107.019 39.811 1.00 19.53 ? 2361 HOH M O 1 HETATM 4731 O O . HOH GA 11 . ? 54.362 94.284 48.846 1.00 33.33 ? 2362 HOH M O 1 HETATM 4732 O O . HOH GA 11 . ? 52.961 107.185 53.275 1.00 11.21 ? 2363 HOH M O 1 HETATM 4733 O O . HOH GA 11 . ? 40.559 96.659 58.803 1.00 11.57 ? 2364 HOH M O 1 HETATM 4734 O O . HOH GA 11 . ? 45.548 94.177 62.816 1.00 19.46 ? 2365 HOH M O 1 HETATM 4735 O O . HOH GA 11 . ? 49.293 89.793 62.490 1.00 62.59 ? 2366 HOH M O 1 HETATM 4736 O O . HOH GA 11 . ? 43.550 90.137 63.229 1.00 57.67 ? 2367 HOH M O 1 HETATM 4737 O O . HOH GA 11 . ? 37.037 100.087 68.017 1.00 24.11 ? 2368 HOH M O 1 HETATM 4738 O O . HOH GA 11 . ? 40.242 105.515 71.194 1.00 11.20 ? 2369 HOH M O 1 HETATM 4739 O O . HOH GA 11 . ? 38.496 96.344 60.711 1.00 15.96 ? 2370 HOH M O 1 HETATM 4740 O O . HOH GA 11 . ? 34.877 96.366 67.147 1.00 16.91 ? 2371 HOH M O 1 HETATM 4741 O O . HOH GA 11 . ? 40.409 91.161 70.689 1.00 34.44 ? 2372 HOH M O 1 HETATM 4742 O O . HOH GA 11 . ? 41.408 88.452 64.780 1.00 39.08 ? 2373 HOH M O 1 HETATM 4743 O O . HOH GA 11 . ? 38.488 95.463 71.548 1.00 18.84 ? 2374 HOH M O 1 HETATM 4744 O O . HOH GA 11 . ? 44.177 96.133 74.283 1.00 61.28 ? 2375 HOH M O 1 HETATM 4745 O O . HOH GA 11 . ? 47.246 97.821 75.331 1.00 55.51 ? 2376 HOH M O 1 HETATM 4746 O O . HOH GA 11 . ? 36.960 102.100 70.167 1.00 15.26 ? 2377 HOH M O 1 HETATM 4747 O O . HOH GA 11 . ? 33.328 100.493 70.264 1.00 34.66 ? 2378 HOH M O 1 HETATM 4748 O O . HOH GA 11 . ? 32.191 98.465 72.100 1.00 30.41 ? 2379 HOH M O 1 HETATM 4749 O O . HOH GA 11 . ? 34.321 99.186 67.722 1.00 47.57 ? 2380 HOH M O 1 HETATM 4750 O O . HOH GA 11 . ? 34.673 100.875 78.258 1.00 41.77 ? 2381 HOH M O 1 HETATM 4751 O O . HOH GA 11 . ? 43.931 99.412 76.455 1.00 43.57 ? 2382 HOH M O 1 HETATM 4752 O O . HOH GA 11 . ? 38.959 95.635 74.295 1.00 30.15 ? 2383 HOH M O 1 HETATM 4753 O O . HOH GA 11 . ? 32.704 107.345 73.105 1.00 22.61 ? 2384 HOH M O 1 HETATM 4754 O O . HOH GA 11 . ? 32.000 106.338 69.189 1.00 32.38 ? 2385 HOH M O 1 HETATM 4755 O O . HOH GA 11 . ? 30.823 103.914 70.837 1.00 42.50 ? 2386 HOH M O 1 HETATM 4756 O O . HOH GA 11 . ? 33.040 102.995 68.904 1.00 27.81 ? 2387 HOH M O 1 HETATM 4757 O O . HOH GA 11 . ? 27.483 106.118 66.079 1.00 61.79 ? 2388 HOH M O 1 HETATM 4758 O O . HOH GA 11 . ? 30.803 103.230 66.966 1.00 68.27 ? 2389 HOH M O 1 HETATM 4759 O O . HOH GA 11 . ? 43.359 110.611 49.195 1.00 7.31 ? 2390 HOH M O 1 HETATM 4760 O O . HOH GA 11 . ? 41.055 119.732 46.868 1.00 8.49 ? 2391 HOH M O 1 HETATM 4761 O O . HOH GA 11 . ? 43.679 119.495 46.161 1.00 18.92 ? 2392 HOH M O 1 HETATM 4762 O O . HOH GA 11 . ? 29.103 117.713 38.281 1.00 21.30 ? 2393 HOH M O 1 HETATM 4763 O O . HOH GA 11 . ? 31.653 116.060 37.007 1.00 11.36 ? 2394 HOH M O 1 HETATM 4764 O O . HOH GA 11 . ? 33.109 123.070 31.305 1.00 9.82 ? 2395 HOH M O 1 HETATM 4765 O O . HOH GA 11 . ? 41.312 123.774 23.966 1.00 43.67 ? 2396 HOH M O 1 HETATM 4766 O O . HOH GA 11 . ? 37.377 121.070 23.706 1.00 23.87 ? 2397 HOH M O 1 HETATM 4767 O O . HOH GA 11 . ? 26.724 123.937 31.334 1.00 83.12 ? 2398 HOH M O 1 HETATM 4768 O O . HOH GA 11 . ? 29.127 124.114 26.584 1.00 35.94 ? 2399 HOH M O 1 HETATM 4769 O O . HOH GA 11 . ? 26.509 117.660 27.541 1.00 45.45 ? 2400 HOH M O 1 HETATM 4770 O O . HOH GA 11 . ? 28.868 116.990 30.518 1.00 24.48 ? 2401 HOH M O 1 HETATM 4771 O O . HOH GA 11 . ? 29.464 116.561 20.976 1.00 38.56 ? 2402 HOH M O 1 HETATM 4772 O O . HOH GA 11 . ? 29.343 119.495 20.958 1.00 42.59 ? 2403 HOH M O 1 HETATM 4773 O O . HOH GA 11 . ? 38.225 118.766 25.467 1.00 25.62 ? 2404 HOH M O 1 HETATM 4774 O O . HOH GA 11 . ? 39.054 116.095 22.977 1.00 47.82 ? 2405 HOH M O 1 HETATM 4775 O O . HOH GA 11 . ? 34.017 108.508 24.581 1.00 22.13 ? 2406 HOH M O 1 HETATM 4776 O O . HOH GA 11 . ? 35.106 106.392 18.858 1.00 54.78 ? 2407 HOH M O 1 HETATM 4777 O O . HOH GA 11 . ? 33.525 110.276 17.384 1.00 53.70 ? 2408 HOH M O 1 HETATM 4778 O O . HOH GA 11 . ? 36.738 107.101 21.832 1.00 62.40 ? 2409 HOH M O 1 HETATM 4779 O O . HOH GA 11 . ? 38.089 107.942 19.302 1.00 62.47 ? 2410 HOH M O 1 HETATM 4780 O O . HOH GA 11 . ? 31.708 114.643 21.771 1.00 20.22 ? 2411 HOH M O 1 HETATM 4781 O O . HOH GA 11 . ? 39.126 110.710 27.223 1.00 17.66 ? 2412 HOH M O 1 HETATM 4782 O O . HOH GA 11 . ? 35.471 112.691 18.256 1.00 39.40 ? 2413 HOH M O 1 HETATM 4783 O O . HOH GA 11 . ? 33.727 107.788 37.293 1.00 20.83 ? 2414 HOH M O 1 HETATM 4784 O O . HOH GA 11 . ? 31.910 114.010 33.515 1.00 34.60 ? 2415 HOH M O 1 HETATM 4785 O O . HOH GA 11 . ? 29.936 109.862 38.188 1.00 28.93 ? 2416 HOH M O 1 HETATM 4786 O O . HOH GA 11 . ? 37.623 106.203 29.725 1.00 23.08 ? 2417 HOH M O 1 HETATM 4787 O O . HOH GA 11 . ? 42.674 107.699 27.847 1.00 54.42 ? 2418 HOH M O 1 HETATM 4788 O O . HOH GA 11 . ? 29.489 112.455 39.068 1.00 18.23 ? 2419 HOH M O 1 HETATM 4789 O O . HOH GA 11 . ? 34.585 101.695 40.542 1.00 17.54 ? 2420 HOH M O 1 HETATM 4790 O O . HOH GA 11 . ? 45.870 108.634 39.953 1.00 20.54 ? 2421 HOH M O 1 HETATM 4791 O O . HOH GA 11 . ? 42.309 111.157 46.746 1.00 10.88 ? 2422 HOH M O 1 HETATM 4792 O O . HOH GA 11 . ? 33.012 100.684 45.472 1.00 17.74 ? 2423 HOH M O 1 HETATM 4793 O O . HOH GA 11 . ? 31.840 97.878 52.165 1.00 38.23 ? 2424 HOH M O 1 HETATM 4794 O O . HOH GA 11 . ? 33.426 93.071 47.455 1.00 46.33 ? 2425 HOH M O 1 HETATM 4795 O O . HOH GA 11 . ? 36.500 92.182 47.109 1.00 39.63 ? 2426 HOH M O 1 HETATM 4796 O O . HOH GA 11 . ? 30.824 96.593 48.188 1.00 36.91 ? 2427 HOH M O 1 HETATM 4797 O O . HOH GA 11 . ? 41.032 92.303 45.720 1.00 60.59 ? 2428 HOH M O 1 HETATM 4798 O O . HOH GA 11 . ? 41.985 95.165 42.729 1.00 11.93 ? 2429 HOH M O 1 HETATM 4799 O O . HOH GA 11 . ? 37.187 96.511 40.676 1.00 16.04 ? 2430 HOH M O 1 HETATM 4800 O O . HOH GA 11 . ? 44.573 94.369 33.138 1.00 43.98 ? 2431 HOH M O 1 HETATM 4801 O O . HOH GA 11 . ? 37.337 99.990 32.917 1.00 26.13 ? 2432 HOH M O 1 HETATM 4802 O O . HOH GA 11 . ? 37.558 95.383 31.812 1.00 67.50 ? 2433 HOH M O 1 HETATM 4803 O O . HOH GA 11 . ? 41.867 93.701 32.202 1.00 56.31 ? 2434 HOH M O 1 HETATM 4804 O O . HOH GA 11 . ? 39.160 99.780 29.656 1.00 50.32 ? 2435 HOH M O 1 HETATM 4805 O O . HOH GA 11 . ? 46.285 95.662 31.110 1.00 52.37 ? 2436 HOH M O 1 HETATM 4806 O O . HOH GA 11 . ? 47.726 100.770 29.527 1.00 40.32 ? 2437 HOH M O 1 HETATM 4807 O O . HOH GA 11 . ? 42.530 101.129 29.864 1.00 48.14 ? 2438 HOH M O 1 HETATM 4808 O O . HOH GA 11 . ? 46.037 95.395 36.976 1.00 16.26 ? 2439 HOH M O 1 HETATM 4809 O O . HOH GA 11 . ? 50.668 95.618 32.163 1.00 39.84 ? 2440 HOH M O 1 HETATM 4810 O O . HOH GA 11 . ? 52.456 95.310 40.831 1.00 28.26 ? 2441 HOH M O 1 HETATM 4811 O O . HOH GA 11 . ? 55.729 95.965 37.139 1.00 41.91 ? 2442 HOH M O 1 HETATM 4812 O O . HOH GA 11 . ? 54.065 99.230 40.642 1.00 16.23 ? 2443 HOH M O 1 HETATM 4813 O O . HOH GA 11 . ? 50.602 99.760 31.995 1.00 35.07 ? 2444 HOH M O 1 HETATM 4814 O O . HOH GA 11 . ? 48.504 92.638 39.538 1.00 57.45 ? 2445 HOH M O 1 HETATM 4815 O O . HOH GA 11 . ? 44.661 94.889 41.634 1.00 19.59 ? 2446 HOH M O 1 HETATM 4816 O O . HOH GA 11 . ? 50.709 92.090 46.046 1.00 32.89 ? 2447 HOH M O 1 HETATM 4817 O O . HOH GA 11 . ? 48.624 89.768 46.809 1.00 39.98 ? 2448 HOH M O 1 HETATM 4818 O O . HOH GA 11 . ? 50.868 92.037 43.115 1.00 34.13 ? 2449 HOH M O 1 HETATM 4819 O O . HOH GA 11 . ? 41.599 89.113 46.037 1.00 51.64 ? 2450 HOH M O 1 HETATM 4820 O O . HOH GA 11 . ? 43.333 92.613 43.764 1.00 27.05 ? 2451 HOH M O 1 HETATM 4821 O O . HOH GA 11 . ? 47.388 87.558 52.611 1.00 34.31 ? 2452 HOH M O 1 HETATM 4822 O O . HOH GA 11 . ? 38.154 88.570 50.078 1.00 32.50 ? 2453 HOH M O 1 HETATM 4823 O O . HOH GA 11 . ? 44.374 85.399 51.371 1.00 28.50 ? 2454 HOH M O 1 HETATM 4824 O O . HOH GA 11 . ? 41.102 89.341 56.337 1.00 23.58 ? 2455 HOH M O 1 HETATM 4825 O O . HOH GA 11 . ? 46.252 90.559 55.359 1.00 44.53 ? 2456 HOH M O 1 HETATM 4826 O O . HOH GA 11 . ? 44.701 90.115 57.983 1.00 39.56 ? 2457 HOH M O 1 HETATM 4827 O O . HOH GA 11 . ? 49.499 92.766 48.581 1.00 23.66 ? 2458 HOH M O 1 HETATM 4828 O O . HOH GA 11 . ? 50.248 89.369 49.447 1.00 51.59 ? 2459 HOH M O 1 HETATM 4829 O O . HOH GA 11 . ? 49.643 91.719 54.099 1.00 60.12 ? 2460 HOH M O 1 HETATM 4830 O O . HOH GA 11 . ? 36.763 91.327 50.040 1.00 37.04 ? 2461 HOH M O 1 HETATM 4831 O O . HOH GA 11 . ? 35.502 93.396 55.057 1.00 20.87 ? 2462 HOH M O 1 HETATM 4832 O O . HOH GA 11 . ? 37.173 89.544 58.653 1.00 81.37 ? 2463 HOH M O 1 HETATM 4833 O O . HOH GA 11 . ? 34.548 89.175 57.283 1.00 46.05 ? 2464 HOH M O 1 HETATM 4834 O O . HOH GA 11 . ? 37.128 96.075 57.455 1.00 19.95 ? 2465 HOH M O 1 HETATM 4835 O O . HOH GA 11 . ? 29.340 94.409 49.986 1.00 59.43 ? 2466 HOH M O 1 HETATM 4836 O O . HOH GA 11 . ? 31.863 100.349 53.584 1.00 50.68 ? 2467 HOH M O 1 HETATM 4837 O O . HOH GA 11 . ? 30.410 104.118 53.724 1.00 18.99 ? 2468 HOH M O 1 HETATM 4838 O O . HOH GA 11 . ? 32.455 100.879 56.550 1.00 43.28 ? 2469 HOH M O 1 HETATM 4839 O O . HOH GA 11 . ? 30.548 104.910 62.286 1.00 29.68 ? 2470 HOH M O 1 HETATM 4840 O O . HOH GA 11 . ? 31.674 101.518 61.737 1.00 33.15 ? 2471 HOH M O 1 HETATM 4841 O O . HOH GA 11 . ? 33.173 100.413 64.841 1.00 47.88 ? 2472 HOH M O 1 HETATM 4842 O O . HOH GA 11 . ? 30.899 105.568 57.896 1.00 14.00 ? 2473 HOH M O 1 HETATM 4843 O O . HOH GA 11 . ? 35.595 101.804 66.151 1.00 21.28 ? 2474 HOH M O 1 HETATM 4844 O O . HOH GA 11 . ? 38.448 124.885 41.856 1.00 6.85 ? 2475 HOH M O 1 HETATM 4845 O O . HOH GA 11 . ? 28.309 120.981 11.807 1.00 54.06 ? 2476 HOH M O 1 HETATM 4846 O O . HOH GA 11 . ? 32.288 124.465 12.869 1.00 55.91 ? 2477 HOH M O 1 HETATM 4847 O O . HOH GA 11 . ? 31.906 125.311 34.772 1.00 21.10 ? 2478 HOH M O 1 HETATM 4848 O O . HOH GA 11 . ? 44.015 123.493 28.212 1.00 24.17 ? 2479 HOH M O 1 HETATM 4849 O O . HOH GA 11 . ? 44.070 122.110 25.315 1.00 49.20 ? 2480 HOH M O 1 HETATM 4850 O O . HOH GA 11 . ? 43.004 117.406 25.570 1.00 26.42 ? 2481 HOH M O 1 HETATM 4851 O O . HOH GA 11 . ? 46.106 117.296 26.273 1.00 43.86 ? 2482 HOH M O 1 HETATM 4852 O O . HOH GA 11 . ? 44.887 113.443 24.067 1.00 48.76 ? 2483 HOH M O 1 HETATM 4853 O O . HOH GA 11 . ? 48.699 116.650 27.588 1.00 40.36 ? 2484 HOH M O 1 HETATM 4854 O O . HOH GA 11 . ? 45.607 107.923 27.036 1.00 60.11 ? 2485 HOH M O 1 HETATM 4855 O O . HOH GA 11 . ? 42.566 82.207 32.184 1.00 53.99 ? 2486 HOH M O 1 HETATM 4856 O O . HOH GA 11 . ? 48.170 111.606 30.891 1.00 17.60 ? 2487 HOH M O 1 HETATM 4857 O O . HOH GA 11 . ? 50.963 113.169 28.484 1.00 43.98 ? 2488 HOH M O 1 HETATM 4858 O O . HOH GA 11 . ? 48.906 104.332 26.772 1.00 42.45 ? 2489 HOH M O 1 HETATM 4859 O O . HOH GA 11 . ? 47.957 107.295 25.025 1.00 41.21 ? 2490 HOH M O 1 HETATM 4860 O O . HOH GA 11 . ? 46.794 103.904 28.980 1.00 35.64 ? 2491 HOH M O 1 HETATM 4861 O O . HOH GA 11 . ? 71.359 117.176 41.235 1.00 61.15 ? 2492 HOH M O 1 HETATM 4862 O O . HOH GA 11 . ? 74.485 120.869 42.489 1.00 79.37 ? 2493 HOH M O 1 HETATM 4863 O O . HOH GA 11 . ? 54.905 105.430 25.375 1.00 33.42 ? 2494 HOH M O 1 HETATM 4864 O O . HOH GA 11 . ? 56.434 103.711 22.618 1.00 61.06 ? 2495 HOH M O 1 HETATM 4865 O O . HOH GA 11 . ? 52.704 102.318 24.348 1.00 52.00 ? 2496 HOH M O 1 HETATM 4866 O O . HOH GA 11 . ? 58.690 103.783 30.891 1.00 34.62 ? 2497 HOH M O 1 HETATM 4867 O O . HOH GA 11 . ? 60.907 110.087 28.559 1.00 61.66 ? 2498 HOH M O 1 HETATM 4868 O O . HOH GA 11 . ? 63.761 107.982 34.069 1.00 14.64 ? 2499 HOH M O 1 HETATM 4869 O O . HOH GA 11 . ? 61.610 107.886 26.543 1.00 38.37 ? 2500 HOH M O 1 HETATM 4870 O O . HOH GA 11 . ? 57.385 113.400 33.523 1.00 24.06 ? 2501 HOH M O 1 HETATM 4871 O O . HOH GA 11 . ? 59.358 106.795 34.596 1.00 12.67 ? 2502 HOH M O 1 HETATM 4872 O O . HOH GA 11 . ? 53.085 113.615 35.920 1.00 26.44 ? 2503 HOH M O 1 HETATM 4873 O O . HOH GA 11 . ? 46.886 108.567 37.245 1.00 33.39 ? 2504 HOH M O 1 HETATM 4874 O O . HOH GA 11 . ? 46.464 112.486 37.124 1.00 19.92 ? 2505 HOH M O 1 HETATM 4875 O O . HOH GA 11 . ? 46.751 111.971 33.716 1.00 20.93 ? 2506 HOH M O 1 HETATM 4876 O O . HOH GA 11 . ? 43.041 105.463 32.165 1.00 37.71 ? 2507 HOH M O 1 HETATM 4877 O O . HOH GA 11 . ? 45.107 106.421 30.166 1.00 38.34 ? 2508 HOH M O 1 HETATM 4878 O O . HOH GA 11 . ? 48.847 114.246 32.136 1.00 49.99 ? 2509 HOH M O 1 HETATM 4879 O O . HOH GA 11 . ? 45.891 122.091 37.387 1.00 38.89 ? 2510 HOH M O 1 HETATM 4880 O O . HOH GA 11 . ? 47.584 121.590 32.936 1.00 32.27 ? 2511 HOH M O 1 HETATM 4881 O O . HOH GA 11 . ? 47.451 118.105 34.464 1.00 14.41 ? 2512 HOH M O 1 HETATM 4882 O O . HOH GA 11 . ? 41.466 120.485 31.517 1.00 11.06 ? 2513 HOH M O 1 HETATM 4883 O O . HOH GA 11 . ? 44.481 126.305 34.557 1.00 15.08 ? 2514 HOH M O 1 HETATM 4884 O O . HOH GA 11 . ? 47.215 122.505 40.492 1.00 36.54 ? 2515 HOH M O 1 HETATM 4885 O O . HOH GA 11 . ? 42.604 125.817 29.828 1.00 50.69 ? 2516 HOH M O 1 HETATM 4886 O O . HOH GA 11 . ? 41.062 127.763 27.471 1.00 44.85 ? 2517 HOH M O 1 HETATM 4887 O O . HOH GA 11 . ? 40.142 127.663 24.452 1.00 30.81 ? 2518 HOH M O 1 HETATM 4888 O O . HOH GA 11 . ? 35.320 132.965 28.540 1.00 24.13 ? 2519 HOH M O 1 HETATM 4889 O O . HOH GA 11 . ? 34.337 131.275 24.816 1.00 28.11 ? 2520 HOH M O 1 HETATM 4890 O O . HOH GA 11 . ? 32.801 131.416 29.370 1.00 44.35 ? 2521 HOH M O 1 HETATM 4891 O O . HOH GA 11 . ? 39.386 134.058 30.778 1.00 23.15 ? 2522 HOH M O 1 HETATM 4892 O O . HOH GA 11 . ? 35.470 133.107 36.969 1.00 19.42 ? 2523 HOH M O 1 HETATM 4893 O O . HOH GA 11 . ? 43.842 133.231 30.696 1.00 40.18 ? 2524 HOH M O 1 HETATM 4894 O O . HOH GA 11 . ? 46.232 131.746 32.221 1.00 64.12 ? 2525 HOH M O 1 HETATM 4895 O O . HOH GA 11 . ? 36.272 133.598 33.865 1.00 21.86 ? 2526 HOH M O 1 HETATM 4896 O O . HOH GA 11 . ? 32.319 127.865 37.760 1.00 13.71 ? 2527 HOH M O 1 HETATM 4897 O O . HOH GA 11 . ? 37.793 133.975 38.568 1.00 13.11 ? 2528 HOH M O 1 HETATM 4898 O O . HOH GA 11 . ? 40.487 134.938 46.477 1.00 15.01 ? 2529 HOH M O 1 HETATM 4899 O O . HOH GA 11 . ? 39.581 136.041 42.063 1.00 10.68 ? 2530 HOH M O 1 HETATM 4900 O O . HOH GA 11 . ? 45.149 133.204 47.904 1.00 29.02 ? 2531 HOH M O 1 HETATM 4901 O O . HOH GA 11 . ? 47.721 126.834 48.247 1.00 28.54 ? 2532 HOH M O 1 HETATM 4902 O O . HOH GA 11 . ? 52.576 130.184 46.282 1.00 53.94 ? 2533 HOH M O 1 HETATM 4903 O O . HOH GA 11 . ? 47.430 133.905 46.345 1.00 30.02 ? 2534 HOH M O 1 HETATM 4904 O O . HOH GA 11 . ? 50.849 132.864 46.695 1.00 49.67 ? 2535 HOH M O 1 HETATM 4905 O O . HOH GA 11 . ? 47.516 136.699 37.887 1.00 48.36 ? 2536 HOH M O 1 HETATM 4906 O O . HOH GA 11 . ? 53.517 131.973 30.735 1.00 74.44 ? 2537 HOH M O 1 HETATM 4907 O O . HOH GA 11 . ? 54.613 133.820 34.044 1.00 62.63 ? 2538 HOH M O 1 HETATM 4908 O O . HOH GA 11 . ? 45.831 131.573 35.477 1.00 46.12 ? 2539 HOH M O 1 HETATM 4909 O O . HOH GA 11 . ? 50.951 138.555 35.141 1.00 54.09 ? 2540 HOH M O 1 HETATM 4910 O O . HOH GA 11 . ? 53.055 136.651 33.681 1.00 54.04 ? 2541 HOH M O 1 HETATM 4911 O O . HOH GA 11 . ? 46.539 128.705 31.895 1.00 50.24 ? 2542 HOH M O 1 HETATM 4912 O O . HOH GA 11 . ? 45.721 135.732 39.997 1.00 74.04 ? 2543 HOH M O 1 HETATM 4913 O O . HOH GA 11 . ? 45.250 128.543 36.114 1.00 19.80 ? 2544 HOH M O 1 HETATM 4914 O O . HOH GA 11 . ? 43.112 135.887 38.390 1.00 41.69 ? 2545 HOH M O 1 HETATM 4915 O O . HOH GA 11 . ? 45.572 135.624 35.797 1.00 40.99 ? 2546 HOH M O 1 HETATM 4916 O O . HOH GA 11 . ? 38.552 134.364 48.482 1.00 10.46 ? 2547 HOH M O 1 HETATM 4917 O O . HOH GA 11 . ? 29.734 120.703 40.452 1.00 11.29 ? 2548 HOH M O 1 HETATM 4918 O O . HOH GA 11 . ? 30.202 124.683 37.052 1.00 51.90 ? 2549 HOH M O 1 HETATM 4919 O O . HOH GA 11 . ? 31.111 127.057 42.918 1.00 10.98 ? 2550 HOH M O 1 HETATM 4920 O O . HOH GA 11 . ? 27.101 120.551 38.728 1.00 42.27 ? 2551 HOH M O 1 HETATM 4921 O O . HOH GA 11 . ? 27.540 117.153 40.974 1.00 52.14 ? 2552 HOH M O 1 HETATM 4922 O O . HOH GA 11 . ? 26.436 119.426 42.569 1.00 67.11 ? 2553 HOH M O 1 HETATM 4923 O O . HOH GA 11 . ? 24.310 112.415 48.278 1.00 79.50 ? 2554 HOH M O 1 HETATM 4924 O O . HOH GA 11 . ? 25.865 111.248 43.057 1.00 48.16 ? 2555 HOH M O 1 HETATM 4925 O O . HOH GA 11 . ? 27.974 115.000 43.016 1.00 12.89 ? 2556 HOH M O 1 HETATM 4926 O O . HOH GA 11 . ? 24.732 116.937 43.002 1.00 53.23 ? 2557 HOH M O 1 HETATM 4927 O O . HOH GA 11 . ? 23.490 114.234 41.917 1.00 51.42 ? 2558 HOH M O 1 HETATM 4928 O O . HOH GA 11 . ? 22.213 113.039 44.397 1.00 24.59 ? 2559 HOH M O 1 HETATM 4929 O O . HOH GA 11 . ? 35.351 107.444 41.895 1.00 18.39 ? 2560 HOH M O 1 HETATM 4930 O O . HOH GA 11 . ? 21.876 106.321 51.329 1.00 44.59 ? 2561 HOH M O 1 HETATM 4931 O O . HOH GA 11 . ? 24.153 105.536 49.094 1.00 29.88 ? 2562 HOH M O 1 HETATM 4932 O O . HOH GA 11 . ? 18.972 109.344 51.809 1.00 57.35 ? 2563 HOH M O 1 HETATM 4933 O O . HOH GA 11 . ? 26.739 103.825 47.289 1.00 17.59 ? 2564 HOH M O 1 HETATM 4934 O O . HOH GA 11 . ? 23.292 105.287 45.398 1.00 46.26 ? 2565 HOH M O 1 HETATM 4935 O O . HOH GA 11 . ? 26.332 106.626 42.271 1.00 53.86 ? 2566 HOH M O 1 HETATM 4936 O O . HOH GA 11 . ? 27.061 103.752 42.850 1.00 54.35 ? 2567 HOH M O 1 HETATM 4937 O O . HOH GA 11 . ? 21.953 107.416 48.309 1.00 70.19 ? 2568 HOH M O 1 HETATM 4938 O O . HOH GA 11 . ? 29.742 107.147 39.513 1.00 46.86 ? 2569 HOH M O 1 HETATM 4939 O O . HOH GA 11 . ? 31.889 101.936 39.098 1.00 71.72 ? 2570 HOH M O 1 HETATM 4940 O O . HOH GA 11 . ? 28.523 104.055 39.746 1.00 63.24 ? 2571 HOH M O 1 HETATM 4941 O O . HOH GA 11 . ? 29.964 101.946 41.645 1.00 42.45 ? 2572 HOH M O 1 HETATM 4942 O O . HOH GA 11 . ? 30.896 102.312 44.377 1.00 24.95 ? 2573 HOH M O 1 HETATM 4943 O O . HOH GA 11 . ? 27.598 101.791 45.166 1.00 50.67 ? 2574 HOH M O 1 HETATM 4944 O O . HOH GA 11 . ? 35.796 103.944 42.948 1.00 16.33 ? 2575 HOH M O 1 HETATM 4945 O O . HOH GA 11 . ? 29.210 96.721 43.968 1.00 57.18 ? 2576 HOH M O 1 HETATM 4946 O O . HOH GA 11 . ? 31.379 98.396 45.550 1.00 26.77 ? 2577 HOH M O 1 HETATM 4947 O O . HOH GA 11 . ? 28.703 101.973 55.074 1.00 55.50 ? 2578 HOH M O 1 HETATM 4948 O O . HOH GA 11 . ? 26.766 110.245 53.912 1.00 10.16 ? 2579 HOH M O 1 HETATM 4949 O O . HOH GA 11 . ? 22.801 103.638 54.158 1.00 38.00 ? 2580 HOH M O 1 HETATM 4950 O O . HOH GA 11 . ? 20.520 107.932 54.733 1.00 42.25 ? 2581 HOH M O 1 HETATM 4951 O O . HOH GA 11 . ? 26.230 107.146 57.570 1.00 17.31 ? 2582 HOH M O 1 HETATM 4952 O O . HOH GA 11 . ? 26.295 103.910 55.909 1.00 33.64 ? 2583 HOH M O 1 HETATM 4953 O O . HOH GA 11 . ? 23.240 107.245 57.943 1.00 34.96 ? 2584 HOH M O 1 HETATM 4954 O O . HOH GA 11 . ? 30.268 110.389 65.233 1.00 26.73 ? 2585 HOH M O 1 HETATM 4955 O O . HOH GA 11 . ? 30.732 114.034 66.422 1.00 45.86 ? 2586 HOH M O 1 HETATM 4956 O O . HOH GA 11 . ? 45.808 128.934 48.738 1.00 20.46 ? 2587 HOH M O 1 HETATM 4957 O O . HOH GA 11 . ? 48.732 132.752 48.732 1.00 26.45 ? 2588 HOH M O 1 HETATM 4958 O O . HOH GA 11 . ? 46.714 135.804 56.404 1.00 20.55 ? 2589 HOH M O 1 HETATM 4959 O O . HOH GA 11 . ? 49.241 136.748 54.390 1.00 26.11 ? 2590 HOH M O 1 HETATM 4960 O O . HOH GA 11 . ? 57.509 135.294 53.790 1.00 53.89 ? 2591 HOH M O 1 HETATM 4961 O O . HOH GA 11 . ? 55.647 137.085 56.478 1.00 66.27 ? 2592 HOH M O 1 HETATM 4962 O O . HOH GA 11 . ? 54.611 135.511 49.116 1.00 47.29 ? 2593 HOH M O 1 HETATM 4963 O O . HOH GA 11 . ? 56.272 140.155 54.841 1.00 53.19 ? 2594 HOH M O 1 HETATM 4964 O O . HOH GA 11 . ? 57.536 135.062 50.566 1.00 39.48 ? 2595 HOH M O 1 HETATM 4965 O O . HOH GA 11 . ? 45.555 138.411 50.061 1.00 45.80 ? 2596 HOH M O 1 HETATM 4966 O O . HOH GA 11 . ? 48.444 140.161 48.371 1.00 58.24 ? 2597 HOH M O 1 HETATM 4967 O O . HOH GA 11 . ? 45.554 138.788 53.860 1.00 26.82 ? 2598 HOH M O 1 HETATM 4968 O O . HOH GA 11 . ? 55.265 143.686 59.044 1.00 42.32 ? 2599 HOH M O 1 HETATM 4969 O O . HOH GA 11 . ? 52.856 140.220 65.513 1.00 50.53 ? 2600 HOH M O 1 HETATM 4970 O O . HOH GA 11 . ? 52.359 145.844 59.496 1.00 70.58 ? 2601 HOH M O 1 HETATM 4971 O O . HOH GA 11 . ? 45.124 145.372 61.056 1.00 56.47 ? 2602 HOH M O 1 HETATM 4972 O O . HOH GA 11 . ? 41.535 140.548 51.729 1.00 31.37 ? 2603 HOH M O 1 HETATM 4973 O O . HOH GA 11 . ? 42.722 143.257 52.810 1.00 52.38 ? 2604 HOH M O 1 HETATM 4974 O O . HOH GA 11 . ? 35.537 144.820 59.300 1.00 39.59 ? 2605 HOH M O 1 HETATM 4975 O O . HOH GA 11 . ? 43.257 133.843 50.648 1.00 57.56 ? 2606 HOH M O 1 HETATM 4976 O O . HOH GA 11 . ? 42.975 135.056 47.960 1.00 38.42 ? 2607 HOH M O 1 HETATM 4977 O O . HOH GA 11 . ? 43.300 138.443 52.117 1.00 25.90 ? 2608 HOH M O 1 HETATM 4978 O O . HOH GA 11 . ? 36.591 139.915 50.031 1.00 23.85 ? 2609 HOH M O 1 HETATM 4979 O O . HOH GA 11 . ? 34.403 139.064 53.702 1.00 32.78 ? 2610 HOH M O 1 HETATM 4980 O O . HOH GA 11 . ? 37.551 136.938 48.479 1.00 13.82 ? 2611 HOH M O 1 HETATM 4981 O O . HOH GA 11 . ? 36.960 124.934 46.142 1.00 7.63 ? 2612 HOH M O 1 HETATM 4982 O O . HOH GA 11 . ? 23.797 127.482 53.752 1.00 38.12 ? 2613 HOH M O 1 HETATM 4983 O O . HOH GA 11 . ? 23.466 121.481 57.688 1.00 35.13 ? 2614 HOH M O 1 HETATM 4984 O O . HOH GA 11 . ? 20.160 126.409 57.005 1.00 41.36 ? 2615 HOH M O 1 HETATM 4985 O O . HOH GA 11 . ? 20.014 127.145 44.252 1.00 48.00 ? 2616 HOH M O 1 HETATM 4986 O O . HOH GA 11 . ? 19.231 116.256 55.657 1.00 42.30 ? 2617 HOH M O 1 HETATM 4987 O O . HOH GA 11 . ? 21.124 120.309 58.858 1.00 48.46 ? 2618 HOH M O 1 HETATM 4988 O O . HOH GA 11 . ? 17.428 115.347 52.401 1.00 56.66 ? 2619 HOH M O 1 HETATM 4989 O O . HOH GA 11 . ? 17.587 123.914 49.855 1.00 35.40 ? 2620 HOH M O 1 HETATM 4990 O O . HOH GA 11 . ? 18.249 113.339 49.761 1.00 41.14 ? 2621 HOH M O 1 HETATM 4991 O O . HOH GA 11 . ? 21.380 111.996 48.403 1.00 22.55 ? 2622 HOH M O 1 HETATM 4992 O O . HOH GA 11 . ? 18.108 116.395 45.718 1.00 62.06 ? 2623 HOH M O 1 HETATM 4993 O O . HOH GA 11 . ? 21.570 117.349 42.056 1.00 51.90 ? 2624 HOH M O 1 HETATM 4994 O O . HOH GA 11 . ? 22.764 110.014 55.371 1.00 23.21 ? 2625 HOH M O 1 HETATM 4995 O O . HOH GA 11 . ? 22.678 114.580 57.249 1.00 27.64 ? 2626 HOH M O 1 HETATM 4996 O O . HOH GA 11 . ? 26.350 108.480 61.999 1.00 26.38 ? 2627 HOH M O 1 HETATM 4997 O O . HOH GA 11 . ? 24.883 117.166 60.192 1.00 18.19 ? 2628 HOH M O 1 HETATM 4998 O O . HOH GA 11 . ? 23.577 115.592 62.941 1.00 63.29 ? 2629 HOH M O 1 HETATM 4999 O O . HOH GA 11 . ? 49.225 127.313 64.107 1.00 37.43 ? 2630 HOH M O 1 HETATM 5000 O O . HOH GA 11 . ? 51.661 127.355 63.188 1.00 39.72 ? 2631 HOH M O 1 HETATM 5001 O O . HOH GA 11 . ? 48.173 125.246 62.541 1.00 24.69 ? 2632 HOH M O 1 HETATM 5002 O O . HOH GA 11 . ? 53.026 130.424 57.174 1.00 25.92 ? 2633 HOH M O 1 HETATM 5003 O O . HOH GA 11 . ? 49.464 122.965 60.757 1.00 18.65 ? 2634 HOH M O 1 HETATM 5004 O O . HOH GA 11 . ? 50.266 125.585 49.102 1.00 30.27 ? 2635 HOH M O 1 HETATM 5005 O O . HOH GA 11 . ? 51.643 122.135 49.719 1.00 30.83 ? 2636 HOH M O 1 HETATM 5006 O O . HOH GA 11 . ? 57.035 123.791 45.554 1.00 70.94 ? 2637 HOH M O 1 HETATM 5007 O O . HOH GA 11 . ? 53.748 133.023 47.615 1.00 55.74 ? 2638 HOH M O 1 HETATM 5008 O O . HOH GA 11 . ? 56.004 137.312 60.528 1.00 29.40 ? 2639 HOH M O 1 HETATM 5009 O O . HOH GA 11 . ? 52.409 137.426 55.265 1.00 37.55 ? 2640 HOH M O 1 HETATM 5010 O O . HOH GA 11 . ? 42.758 128.954 55.671 1.00 9.46 ? 2641 HOH M O 1 HETATM 5011 O O . HOH GA 11 . ? 50.464 128.487 57.161 1.00 15.15 ? 2642 HOH M O 1 HETATM 5012 O O . HOH GA 11 . ? 53.801 139.433 58.061 1.00 72.99 ? 2643 HOH M O 1 HETATM 5013 O O . HOH GA 11 . ? 56.041 139.845 67.830 1.00 75.31 ? 2644 HOH M O 1 HETATM 5014 O O . HOH GA 11 . ? 62.177 133.314 65.516 1.00 54.10 ? 2645 HOH M O 1 HETATM 5015 O O . HOH GA 11 . ? 60.596 131.884 62.681 1.00 30.94 ? 2646 HOH M O 1 HETATM 5016 O O . HOH GA 11 . ? 54.448 133.008 56.689 1.00 49.06 ? 2647 HOH M O 1 HETATM 5017 O O . HOH GA 11 . ? 54.661 136.753 70.053 1.00 34.06 ? 2648 HOH M O 1 HETATM 5018 O O . HOH GA 11 . ? 60.292 133.215 68.106 1.00 36.39 ? 2649 HOH M O 1 HETATM 5019 O O . HOH GA 11 . ? 59.322 133.406 71.259 1.00 59.74 ? 2650 HOH M O 1 HETATM 5020 O O . HOH GA 11 . ? 57.658 134.434 75.281 1.00 76.34 ? 2651 HOH M O 1 HETATM 5021 O O . HOH GA 11 . ? 50.890 140.073 69.666 1.00 44.37 ? 2652 HOH M O 1 HETATM 5022 O O . HOH GA 11 . ? 53.346 135.511 67.015 1.00 26.02 ? 2653 HOH M O 1 HETATM 5023 O O . HOH GA 11 . ? 50.725 137.982 74.898 1.00 57.49 ? 2654 HOH M O 1 HETATM 5024 O O . HOH GA 11 . ? 48.841 133.882 71.840 1.00 60.08 ? 2655 HOH M O 1 HETATM 5025 O O . HOH GA 11 . ? 46.956 136.393 71.822 1.00 65.85 ? 2656 HOH M O 1 HETATM 5026 O O . HOH GA 11 . ? 45.171 139.082 70.349 1.00 71.73 ? 2657 HOH M O 1 HETATM 5027 O O . HOH GA 11 . ? 43.611 139.534 67.058 1.00 36.39 ? 2658 HOH M O 1 HETATM 5028 O O . HOH GA 11 . ? 43.210 136.797 69.232 1.00 38.02 ? 2659 HOH M O 1 HETATM 5029 O O . HOH GA 11 . ? 35.988 139.282 61.102 1.00 20.10 ? 2660 HOH M O 1 HETATM 5030 O O . HOH GA 11 . ? 38.956 143.515 64.321 1.00 43.11 ? 2661 HOH M O 1 HETATM 5031 O O . HOH GA 11 . ? 42.376 141.945 62.960 1.00 50.53 ? 2662 HOH M O 1 HETATM 5032 O O . HOH GA 11 . ? 34.293 137.824 66.706 1.00 26.89 ? 2663 HOH M O 1 HETATM 5033 O O . HOH GA 11 . ? 36.172 141.251 63.268 1.00 31.87 ? 2664 HOH M O 1 HETATM 5034 O O . HOH GA 11 . ? 32.747 131.346 69.082 1.00 16.04 ? 2665 HOH M O 1 HETATM 5035 O O . HOH GA 11 . ? 38.100 138.214 68.628 1.00 44.08 ? 2666 HOH M O 1 HETATM 5036 O O . HOH GA 11 . ? 27.764 138.131 66.232 1.00 46.55 ? 2667 HOH M O 1 HETATM 5037 O O . HOH GA 11 . ? 29.155 125.602 67.810 1.00 55.86 ? 2668 HOH M O 1 HETATM 5038 O O . HOH GA 11 . ? 28.635 127.889 69.859 1.00 34.86 ? 2669 HOH M O 1 HETATM 5039 O O . HOH GA 11 . ? 31.258 135.221 69.381 1.00 44.85 ? 2670 HOH M O 1 HETATM 5040 O O . HOH GA 11 . ? 25.943 131.943 70.445 1.00 31.74 ? 2671 HOH M O 1 HETATM 5041 O O . HOH GA 11 . ? 17.464 133.377 65.243 1.00 43.33 ? 2672 HOH M O 1 HETATM 5042 O O . HOH GA 11 . ? 20.695 129.247 56.214 1.00 43.74 ? 2673 HOH M O 1 HETATM 5043 O O . HOH GA 11 . ? 32.924 133.217 71.362 1.00 31.41 ? 2674 HOH M O 1 HETATM 5044 O O . HOH GA 11 . ? 25.668 129.095 69.840 1.00 50.35 ? 2675 HOH M O 1 HETATM 5045 O O . HOH GA 11 . ? 63.707 99.396 33.304 1.00 39.11 ? 2676 HOH M O 1 HETATM 5046 O O . HOH GA 11 . ? 65.987 104.240 36.188 1.00 36.99 ? 2677 HOH M O 1 HETATM 5047 O O . HOH GA 11 . ? 61.706 97.989 38.620 1.00 57.23 ? 2678 HOH M O 1 HETATM 5048 O O . HOH GA 11 . ? 59.821 100.737 30.295 1.00 42.16 ? 2679 HOH M O 1 HETATM 5049 O O . HOH GA 11 . ? 59.110 104.103 33.721 1.00 18.97 ? 2680 HOH M O 1 HETATM 5050 O O . HOH GA 11 . ? 53.545 98.883 32.383 1.00 42.82 ? 2681 HOH M O 1 HETATM 5051 O O . HOH GA 11 . ? 59.618 94.127 34.391 1.00 52.94 ? 2682 HOH M O 1 HETATM 5052 O O . HOH GA 11 . ? 44.560 93.001 73.785 1.00 48.61 ? 2683 HOH M O 1 HETATM 5053 O O . HOH GA 11 . ? 42.745 90.506 68.491 1.00 63.18 ? 2684 HOH M O 1 HETATM 5054 O O . HOH GA 11 . ? 38.093 126.630 22.201 1.00 46.02 ? 2685 HOH M O 1 HETATM 5055 O O . HOH GA 11 . ? 38.870 123.315 22.247 1.00 53.74 ? 2686 HOH M O 1 HETATM 5056 O O . HOH GA 11 . ? 34.381 115.278 20.191 1.00 58.78 ? 2687 HOH M O 1 HETATM 5057 O O . HOH GA 11 . ? 31.064 124.706 23.036 1.00 33.78 ? 2688 HOH M O 1 HETATM 5058 O O . HOH GA 11 . ? 36.876 122.895 19.341 1.00 51.42 ? 2689 HOH M O 1 HETATM 5059 O O . HOH GA 11 . ? 36.962 119.255 21.319 1.00 38.55 ? 2690 HOH M O 1 HETATM 5060 O O . HOH GA 11 . ? 29.711 122.463 20.033 1.00 78.96 ? 2691 HOH M O 1 HETATM 5061 O O . HOH GA 11 . ? 31.697 118.108 12.046 1.00 54.49 ? 2692 HOH M O 1 HETATM 5062 O O . HOH GA 11 . ? 29.949 122.466 14.076 1.00 55.04 ? 2693 HOH M O 1 HETATM 5063 O O . HOH GA 11 . ? 29.081 119.027 14.140 1.00 52.88 ? 2694 HOH M O 1 HETATM 5064 O O . HOH GA 11 . ? 32.378 114.416 12.306 1.00 52.14 ? 2695 HOH M O 1 HETATM 5065 O O . HOH GA 11 . ? 30.806 94.694 42.534 1.00 50.31 ? 2696 HOH M O 1 HETATM 5066 O O . HOH GA 11 . ? 36.736 99.248 43.145 1.00 17.41 ? 2697 HOH M O 1 HETATM 5067 O O . HOH GA 11 . ? 35.725 88.085 46.267 1.00 66.23 ? 2698 HOH M O 1 HETATM 5068 O O . HOH GA 11 . ? 38.367 90.657 45.263 1.00 57.66 ? 2699 HOH M O 1 HETATM 5069 O O . HOH GA 11 . ? 30.285 92.798 34.708 1.00 51.23 ? 2700 HOH M O 1 HETATM 5070 O O . HOH GA 11 . ? 33.786 97.707 35.198 1.00 20.22 ? 2701 HOH M O 1 HETATM 5071 O O . HOH GA 11 . ? 35.732 93.578 34.131 1.00 50.36 ? 2702 HOH M O 1 HETATM 5072 O O . HOH GA 11 . ? 28.759 94.889 39.939 1.00 76.35 ? 2703 HOH M O 1 HETATM 5073 O O . HOH GA 11 . ? 30.375 95.786 37.325 1.00 65.90 ? 2704 HOH M O 1 HETATM 5074 O O . HOH GA 11 . ? 37.813 93.744 40.710 1.00 21.16 ? 2705 HOH M O 1 HETATM 5075 O O . HOH GA 11 . ? 29.118 88.593 41.770 1.00 61.45 ? 2706 HOH M O 1 HETATM 5076 O O . HOH GA 11 . ? 36.380 87.323 42.745 1.00 42.36 ? 2707 HOH M O 1 HETATM 5077 O O . HOH GA 11 . ? 36.872 87.223 30.881 1.00 39.23 ? 2708 HOH M O 1 HETATM 5078 O O . HOH GA 11 . ? 41.524 85.173 35.335 1.00 55.40 ? 2709 HOH M O 1 HETATM 5079 O O . HOH GA 11 . ? 40.977 85.985 31.046 1.00 41.05 ? 2710 HOH M O 1 HETATM 5080 O O . HOH GA 11 . ? 36.864 84.550 32.284 1.00 83.37 ? 2711 HOH M O 1 HETATM 5081 O O . HOH GA 11 . ? 42.923 92.006 39.649 1.00 56.22 ? 2712 HOH M O 1 HETATM 5082 O O . HOH GA 11 . ? 37.359 85.786 38.546 1.00 47.02 ? 2713 HOH M O 1 HETATM 5083 O O . HOH GA 11 . ? 38.165 89.551 41.145 1.00 62.37 ? 2714 HOH M O 1 HETATM 5084 O O . HOH GA 11 . ? 37.134 108.215 80.403 1.00 80.79 ? 2715 HOH M O 1 HETATM 5085 O O . HOH GA 11 . ? 38.198 91.897 33.820 1.00 35.30 ? 2716 HOH M O 1 HETATM 5086 O O . HOH GA 11 . ? 40.357 91.860 38.242 1.00 27.27 ? 2717 HOH M O 1 HETATM 5087 O O . HOH GA 11 . ? 45.695 92.959 35.476 1.00 34.80 ? 2718 HOH M O 1 HETATM 5088 O O . HOH GA 11 . ? 43.702 87.137 30.194 1.00 76.73 ? 2719 HOH M O 1 HETATM 5089 O O . HOH GA 11 . ? 38.542 89.666 31.420 1.00 72.77 ? 2720 HOH M O 1 HETATM 5090 O O . HOH GA 11 . ? 36.828 79.734 30.253 1.00 17.63 ? 2721 HOH M O 1 HETATM 5091 O O . HOH GA 11 . ? 39.670 83.488 32.825 1.00 61.46 ? 2722 HOH M O 1 HETATM 5092 O O . HOH GA 11 . ? 39.579 82.129 29.909 1.00 78.61 ? 2723 HOH M O 1 HETATM 5093 O O . HOH GA 11 . ? 33.857 81.869 33.020 1.00 34.61 ? 2724 HOH M O 1 HETATM 5094 O O . HOH GA 11 . ? 34.574 84.160 38.797 1.00 65.73 ? 2725 HOH M O 1 HETATM 5095 O O . HOH GA 11 . ? 72.267 121.278 44.599 1.00 57.96 ? 2726 HOH M O 1 HETATM 5096 O O . HOH GA 11 . ? 69.524 124.778 46.776 1.00 58.65 ? 2727 HOH M O 1 HETATM 5097 O O . HOH GA 11 . ? 71.433 124.555 44.146 1.00 69.22 ? 2728 HOH M O 1 HETATM 5098 O O . HOH GA 11 . ? 70.438 116.340 44.243 1.00 58.19 ? 2729 HOH M O 1 HETATM 5099 O O . HOH GA 11 . ? 55.405 115.078 34.820 1.00 49.89 ? 2730 HOH M O 1 HETATM 5100 O O . HOH GA 11 . ? 60.164 115.031 32.746 1.00 61.79 ? 2731 HOH M O 1 HETATM 5101 O O . HOH GA 11 . ? 29.416 127.682 25.853 1.00 62.77 ? 2732 HOH M O 1 HETATM 5102 O O . HOH GA 11 . ? 29.359 129.484 35.679 1.00 68.48 ? 2733 HOH M O 1 HETATM 5103 O O . HOH GA 11 . ? 30.206 130.438 28.032 1.00 60.95 ? 2734 HOH M O 1 HETATM 5104 O O . HOH GA 11 . ? 30.383 132.498 30.680 1.00 53.71 ? 2735 HOH M O 1 HETATM 5105 O O . HOH GA 11 . ? 24.351 132.508 31.957 1.00 69.13 ? 2736 HOH M O 1 HETATM 5106 O O . HOH GA 11 . ? 54.650 140.350 70.627 1.00 83.01 ? 2737 HOH M O 1 HETATM 5107 O O . HOH GA 11 . ? 60.702 136.310 73.958 1.00 49.95 ? 2738 HOH M O 1 HETATM 5108 O O . HOH GA 11 . ? 50.560 119.850 51.115 1.00 32.64 ? 2739 HOH M O 1 HETATM 5109 O O . HOH GA 11 . ? 49.700 116.890 44.010 1.00 43.24 ? 2740 HOH M O 1 HETATM 5110 O O . HOH GA 11 . ? 46.346 118.493 46.407 0.52 38.98 ? 2741 HOH M O 1 HETATM 5111 O O . HOH GA 11 . ? 49.291 119.557 55.649 0.48 22.96 ? 2742 HOH M O 1 HETATM 5112 O O . HOH GA 11 . ? 47.158 117.775 54.582 0.48 15.87 ? 2743 HOH M O 1 HETATM 5113 O O . HOH GA 11 . ? 66.055 99.685 48.801 1.00 44.82 ? 2744 HOH M O 1 HETATM 5114 O O . HOH GA 11 . ? 67.473 103.776 48.284 1.00 20.71 ? 2745 HOH M O 1 HETATM 5115 O O . HOH GA 11 . ? 68.550 102.754 43.155 1.00 48.73 ? 2746 HOH M O 1 HETATM 5116 O O . HOH GA 11 . ? 69.502 100.515 46.828 1.00 43.25 ? 2747 HOH M O 1 HETATM 5117 O O . HOH GA 11 . ? 63.673 99.318 46.414 1.00 63.11 ? 2748 HOH M O 1 HETATM 5118 O O . HOH GA 11 . ? 68.575 96.632 67.380 1.00 50.90 ? 2749 HOH M O 1 HETATM 5119 O O . HOH GA 11 . ? 67.778 95.319 62.702 1.00 45.73 ? 2750 HOH M O 1 HETATM 5120 O O . HOH GA 11 . ? 64.676 94.162 62.436 1.00 57.67 ? 2751 HOH M O 1 HETATM 5121 O O . HOH GA 11 . ? 48.004 119.824 36.957 1.00 42.71 ? 2752 HOH M O 1 HETATM 5122 O O . HOH GA 11 . ? 48.104 115.233 37.561 1.00 54.50 ? 2753 HOH M O 1 HETATM 5123 O O . HOH GA 11 . ? 27.941 136.436 43.953 1.00 20.73 ? 2754 HOH M O 1 HETATM 5124 O O . HOH GA 11 . ? 23.456 133.257 44.965 1.00 36.30 ? 2755 HOH M O 1 HETATM 5125 O O . HOH GA 11 . ? 25.916 130.579 40.114 1.00 40.50 ? 2756 HOH M O 1 HETATM 5126 O O . HOH GA 11 . ? 24.090 130.707 43.064 1.00 47.87 ? 2757 HOH M O 1 HETATM 5127 O O . HOH GA 11 . ? 24.680 136.840 41.925 1.00 47.99 ? 2758 HOH M O 1 HETATM 5128 O O . HOH GA 11 . ? 26.308 135.034 38.427 1.00 38.42 ? 2759 HOH M O 1 HETATM 5129 O O . HOH GA 11 . ? 67.706 112.298 54.652 1.00 17.05 ? 2760 HOH M O 1 HETATM 5130 O O . HOH GA 11 . ? 31.606 99.486 74.904 1.00 47.90 ? 2761 HOH M O 1 HETATM 5131 O O . HOH GA 11 . ? 32.302 106.449 79.416 1.00 12.12 ? 2762 HOH M O 1 HETATM 5132 O O . HOH GA 11 . ? 36.310 106.448 77.837 1.00 33.04 ? 2763 HOH M O 1 HETATM 5133 O O . HOH GA 11 . ? 31.041 101.316 72.369 1.00 62.55 ? 2764 HOH M O 1 # loop_ _pdbx_poly_seq_scheme.asym_id _pdbx_poly_seq_scheme.entity_id _pdbx_poly_seq_scheme.seq_id _pdbx_poly_seq_scheme.mon_id _pdbx_poly_seq_scheme.ndb_seq_num _pdbx_poly_seq_scheme.pdb_seq_num _pdbx_poly_seq_scheme.auth_seq_num _pdbx_poly_seq_scheme.pdb_mon_id _pdbx_poly_seq_scheme.auth_mon_id _pdbx_poly_seq_scheme.pdb_strand_id _pdbx_poly_seq_scheme.pdb_ins_code _pdbx_poly_seq_scheme.hetero A 1 1 ASP 1 1 ? ? ? M . n A 1 2 GLU 2 2 ? ? ? M . n A 1 3 GLU 3 3 3 GLU GLU M . n A 1 4 ILE 4 4 4 ILE ILE M . n A 1 5 THR 5 5 5 THR THR M . n A 1 6 CYS 6 6 6 CYS CYS M . n A 1 7 GLN 7 7 7 GLN GLN M . n A 1 8 GLU 8 8 8 GLU GLU M . n A 1 9 ASN 9 9 9 ASN ASN M . n A 1 10 LEU 10 10 10 LEU LEU M . n A 1 11 PRO 11 11 11 PRO PRO M . n A 1 12 PHE 12 12 12 PHE PHE M . n A 1 13 THR 13 13 13 THR THR M . n A 1 14 CYS 14 14 14 CYS CYS M . n A 1 15 GLY 15 15 15 GLY GLY M . n A 1 16 ASN 16 16 16 ASN ASN M . n A 1 17 THR 17 17 17 THR THR M . n A 1 18 ASP 18 18 18 ASP ASP M . n A 1 19 ALA 19 19 19 ALA ALA M . n A 1 20 LEU 20 20 20 LEU LEU M . n A 1 21 ASN 21 21 21 ASN ASN M . n A 1 22 SER 22 22 22 SER SER M . n A 1 23 SER 23 23 23 SER SER M . n A 1 24 SER 24 24 24 SER SER M . n A 1 25 PHE 25 25 25 PHE PHE M . n A 1 26 SER 26 26 26 SER SER M . n A 1 27 SER 27 27 27 SER SER M . n A 1 28 ASP 28 28 28 ASP ASP M . n A 1 29 PHE 29 29 29 PHE PHE M . n A 1 30 ILE 30 30 30 ILE ILE M . n A 1 31 PHE 31 31 31 PHE PHE M . n A 1 32 GLY 32 32 32 GLY GLY M . n A 1 33 VAL 33 33 33 VAL VAL M . n A 1 34 ALA 34 34 34 ALA ALA M . n A 1 35 SER 35 35 35 SER SER M . n A 1 36 SER 36 36 36 SER SER M . n A 1 37 ALA 37 37 37 ALA ALA M . n A 1 38 TYR 38 38 38 TYR TYR M . n A 1 39 GLN 39 39 39 GLN GLN M . n A 1 40 ILE 40 40 40 ILE ILE M . n A 1 41 GLU 41 41 41 GLU GLU M . n A 1 42 GLY 42 42 42 GLY GLY M . n A 1 43 THR 43 43 43 THR THR M . n A 1 44 ILE 44 44 44 ILE ILE M . n A 1 45 GLY 45 45 45 GLY GLY M . n A 1 46 ARG 46 46 46 ARG ARG M . n A 1 47 GLY 47 47 47 GLY GLY M . n A 1 48 LEU 48 48 48 LEU LEU M . n A 1 49 ASN 49 49 49 ASN ASN M . n A 1 50 ILE 50 50 50 ILE ILE M . n A 1 51 TRP 51 51 51 TRP TRP M . n A 1 52 ASP 52 52 52 ASP ASP M . n A 1 53 GLY 53 53 53 GLY GLY M . n A 1 54 PHE 54 54 54 PHE PHE M . n A 1 55 THR 55 55 55 THR THR M . n A 1 56 HIS 56 56 56 HIS HIS M . n A 1 57 ARG 57 57 57 ARG ARG M . n A 1 58 TYR 58 58 58 TYR TYR M . n A 1 59 PRO 59 59 59 PRO PRO M . n A 1 60 ASN 60 60 60 ASN ASN M . n A 1 61 LYS 61 61 61 LYS LYS M . n A 1 62 SER 62 62 62 SER SER M . n A 1 63 GLY 63 63 63 GLY GLY M . n A 1 64 PRO 64 64 64 PRO PRO M . n A 1 65 ASP 65 65 65 ASP ASP M . n A 1 66 HIS 66 66 66 HIS HIS M . n A 1 67 GLY 67 67 67 GLY GLY M . n A 1 68 ASN 68 68 68 ASN ASN M . n A 1 69 GLY 69 69 69 GLY GLY M . n A 1 70 ASP 70 70 70 ASP ASP M . n A 1 71 THR 71 71 71 THR THR M . n A 1 72 THR 72 72 72 THR THR M . n A 1 73 CYS 73 73 73 CYS CYS M . n A 1 74 ASP 74 74 74 ASP ASP M . n A 1 75 SER 75 75 75 SER SER M . n A 1 76 PHE 76 76 76 PHE PHE M . n A 1 77 SER 77 77 77 SER SER M . n A 1 78 TYR 78 78 78 TYR TYR M . n A 1 79 TRP 79 79 79 TRP TRP M . n A 1 80 GLN 80 80 80 GLN GLN M . n A 1 81 LYS 81 81 81 LYS LYS M . n A 1 82 ASP 82 82 82 ASP ASP M . n A 1 83 ILE 83 83 83 ILE ILE M . n A 1 84 ASP 84 84 84 ASP ASP M . n A 1 85 VAL 85 85 85 VAL VAL M . n A 1 86 LEU 86 86 86 LEU LEU M . n A 1 87 ASP 87 87 87 ASP ASP M . n A 1 88 GLU 88 88 88 GLU GLU M . n A 1 89 LEU 89 89 89 LEU LEU M . n A 1 90 ASN 90 90 90 ASN ASN M . n A 1 91 ALA 91 91 91 ALA ALA M . n A 1 92 THR 92 92 92 THR THR M . n A 1 93 GLY 93 93 93 GLY GLY M . n A 1 94 TYR 94 94 94 TYR TYR M . n A 1 95 ARG 95 95 95 ARG ARG M . n A 1 96 PHE 96 96 96 PHE PHE M . n A 1 97 SER 97 97 97 SER SER M . n A 1 98 ILE 98 98 98 ILE ILE M . n A 1 99 ALA 99 99 99 ALA ALA M . n A 1 100 TRP 100 100 100 TRP TRP M . n A 1 101 SER 101 101 101 SER SER M . n A 1 102 ARG 102 102 102 ARG ARG M . n A 1 103 ILE 103 103 103 ILE ILE M . n A 1 104 ILE 104 104 104 ILE ILE M . n A 1 105 PRO 105 105 105 PRO PRO M . n A 1 106 ARG 106 106 106 ARG ARG M . n A 1 107 GLY 107 107 107 GLY GLY M . n A 1 108 LYS 108 108 108 LYS LYS M . n A 1 109 ARG 109 109 109 ARG ARG M . n A 1 110 SER 110 110 110 SER SER M . n A 1 111 ARG 111 111 111 ARG ARG M . n A 1 112 GLY 112 112 112 GLY GLY M . n A 1 113 VAL 113 113 113 VAL VAL M . n A 1 114 ASN 114 114 114 ASN ASN M . n A 1 115 GLU 115 115 115 GLU GLU M . n A 1 116 LYS 116 116 116 LYS LYS M . n A 1 117 GLY 117 117 117 GLY GLY M . n A 1 118 ILE 118 118 118 ILE ILE M . n A 1 119 ASP 119 119 119 ASP ASP M . n A 1 120 TYR 120 120 120 TYR TYR M . n A 1 121 TYR 121 121 121 TYR TYR M . n A 1 122 HIS 122 122 122 HIS HIS M . n A 1 123 GLY 123 123 123 GLY GLY M . n A 1 124 LEU 124 124 124 LEU LEU M . n A 1 125 ILE 125 125 125 ILE ILE M . n A 1 126 SER 126 126 126 SER SER M . n A 1 127 GLY 127 127 127 GLY GLY M . n A 1 128 LEU 128 128 128 LEU LEU M . n A 1 129 ILE 129 129 129 ILE ILE M . n A 1 130 LYS 130 130 130 LYS LYS M . n A 1 131 LYS 131 131 131 LYS LYS M . n A 1 132 GLY 132 132 132 GLY GLY M . n A 1 133 ILE 133 133 133 ILE ILE M . n A 1 134 THR 134 134 134 THR THR M . n A 1 135 PRO 135 135 135 PRO PRO M . n A 1 136 PHE 136 136 136 PHE PHE M . n A 1 137 VAL 137 137 137 VAL VAL M . n A 1 138 THR 138 138 138 THR THR M . n A 1 139 LEU 139 139 139 LEU LEU M . n A 1 140 PHE 140 140 140 PHE PHE M . n A 1 141 HIS 141 141 141 HIS HIS M . n A 1 142 TRP 142 142 142 TRP TRP M . n A 1 143 ASP 143 143 143 ASP ASP M . n A 1 144 LEU 144 144 144 LEU LEU M . n A 1 145 PRO 145 145 145 PRO PRO M . n A 1 146 GLN 146 146 146 GLN GLN M . n A 1 147 THR 147 147 147 THR THR M . n A 1 148 LEU 148 148 148 LEU LEU M . n A 1 149 GLN 149 149 149 GLN GLN M . n A 1 150 ASP 150 150 150 ASP ASP M . n A 1 151 GLU 151 151 151 GLU GLU M . n A 1 152 TYR 152 152 152 TYR TYR M . n A 1 153 GLU 153 153 153 GLU GLU M . n A 1 154 GLY 154 154 154 GLY GLY M . n A 1 155 PHE 155 155 155 PHE PHE M . n A 1 156 LEU 156 156 156 LEU LEU M . n A 1 157 ASP 157 157 157 ASP ASP M . n A 1 158 PRO 158 158 158 PRO PRO M . n A 1 159 GLN 159 159 159 GLN GLN M . n A 1 160 ILE 160 160 160 ILE ILE M . n A 1 161 ILE 161 161 161 ILE ILE M . n A 1 162 ASP 162 162 162 ASP ASP M . n A 1 163 ASP 163 163 163 ASP ASP M . n A 1 164 PHE 164 164 164 PHE PHE M . n A 1 165 LYS 165 165 165 LYS LYS M . n A 1 166 ASP 166 166 166 ASP ASP M . n A 1 167 TYR 167 167 167 TYR TYR M . n A 1 168 ALA 168 168 168 ALA ALA M . n A 1 169 ASP 169 169 169 ASP ASP M . n A 1 170 LEU 170 170 170 LEU LEU M . n A 1 171 CYS 171 171 171 CYS CYS M . n A 1 172 PHE 172 172 172 PHE PHE M . n A 1 173 GLU 173 173 173 GLU GLU M . n A 1 174 GLU 174 174 174 GLU GLU M . n A 1 175 PHE 175 175 175 PHE PHE M . n A 1 176 GLY 176 176 176 GLY GLY M . n A 1 177 ASP 177 177 177 ASP ASP M . n A 1 178 SER 178 178 178 SER SER M . n A 1 179 VAL 179 179 179 VAL VAL M . n A 1 180 LYS 180 180 180 LYS LYS M . n A 1 181 TYR 181 181 181 TYR TYR M . n A 1 182 TRP 182 182 182 TRP TRP M . n A 1 183 LEU 183 183 183 LEU LEU M . n A 1 184 THR 184 184 184 THR THR M . n A 1 185 ILE 185 185 185 ILE ILE M . n A 1 186 ASN 186 186 186 ASN ASN M . n A 1 187 GLN 187 187 187 GLN GLN M . n A 1 188 LEU 188 188 188 LEU LEU M . n A 1 189 TYR 189 189 189 TYR TYR M . n A 1 190 SER 190 190 190 SER SER M . n A 1 191 VAL 191 191 191 VAL VAL M . n A 1 192 PRO 192 192 192 PRO PRO M . n A 1 193 THR 193 193 193 THR THR M . n A 1 194 ARG 194 194 194 ARG ARG M . n A 1 195 GLY 195 195 195 GLY GLY M . n A 1 196 TYR 196 196 196 TYR TYR M . n A 1 197 GLY 197 197 197 GLY GLY M . n A 1 198 SER 198 198 198 SER SER M . n A 1 199 ALA 199 199 199 ALA ALA M . n A 1 200 LEU 200 200 200 LEU LEU M . n A 1 201 ASP 201 201 201 ASP ASP M . n A 1 202 ALA 202 202 202 ALA ALA M . n A 1 203 PRO 203 203 203 PRO PRO M . n A 1 204 GLY 204 204 204 GLY GLY M . n A 1 205 ARG 205 205 205 ARG ARG M . n A 1 206 CYS 206 206 206 CYS CYS M . n A 1 207 SER 207 207 207 SER SER M . n A 1 208 PRO 208 208 208 PRO PRO M . n A 1 209 THR 209 209 209 THR THR M . n A 1 210 VAL 210 210 210 VAL VAL M . n A 1 211 ASP 211 211 211 ASP ASP M . n A 1 212 PRO 212 212 212 PRO PRO M . n A 1 213 SER 213 213 213 SER SER M . n A 1 214 CYS 214 214 214 CYS CYS M . n A 1 215 TYR 215 215 215 TYR TYR M . n A 1 216 ALA 216 216 216 ALA ALA M . n A 1 217 GLY 217 217 217 GLY GLY M . n A 1 218 ASN 218 218 218 ASN ASN M . n A 1 219 SER 219 219 219 SER SER M . n A 1 220 SER 220 220 220 SER SER M . n A 1 221 THR 221 221 221 THR THR M . n A 1 222 GLU 222 222 222 GLU GLU M . n A 1 223 PRO 223 223 223 PRO PRO M . n A 1 224 TYR 224 224 224 TYR TYR M . n A 1 225 ILE 225 225 225 ILE ILE M . n A 1 226 VAL 226 226 226 VAL VAL M . n A 1 227 ALA 227 227 227 ALA ALA M . n A 1 228 HIS 228 228 228 HIS HIS M . n A 1 229 HIS 229 229 229 HIS HIS M . n A 1 230 GLN 230 230 230 GLN GLN M . n A 1 231 LEU 231 231 231 LEU LEU M . n A 1 232 LEU 232 232 232 LEU LEU M . n A 1 233 ALA 233 233 233 ALA ALA M . n A 1 234 HIS 234 234 234 HIS HIS M . n A 1 235 ALA 235 235 235 ALA ALA M . n A 1 236 LYS 236 236 236 LYS LYS M . n A 1 237 VAL 237 237 237 VAL VAL M . n A 1 238 VAL 238 238 238 VAL VAL M . n A 1 239 ASP 239 239 239 ASP ASP M . n A 1 240 LEU 240 240 240 LEU LEU M . n A 1 241 TYR 241 241 241 TYR TYR M . n A 1 242 ARG 242 242 242 ARG ARG M . n A 1 243 LYS 243 243 243 LYS LYS M . n A 1 244 ASN 244 244 244 ASN ASN M . n A 1 245 TYR 245 245 245 TYR TYR M . n A 1 246 THR 246 246 246 THR THR M . n A 1 247 HIS 247 247 247 HIS HIS M . n A 1 248 GLN 248 248 248 GLN GLN M . n A 1 249 GLY 249 249 249 GLY GLY M . n A 1 250 GLY 250 250 250 GLY GLY M . n A 1 251 LYS 251 251 251 LYS LYS M . n A 1 252 ILE 252 252 252 ILE ILE M . n A 1 253 GLY 253 253 253 GLY GLY M . n A 1 254 PRO 254 254 254 PRO PRO M . n A 1 255 THR 255 255 255 THR THR M . n A 1 256 MET 256 256 256 MET MET M . n A 1 257 ILE 257 257 257 ILE ILE M . n A 1 258 THR 258 258 258 THR THR M . n A 1 259 ARG 259 259 259 ARG ARG M . n A 1 260 TRP 260 260 260 TRP TRP M . n A 1 261 PHE 261 261 261 PHE PHE M . n A 1 262 LEU 262 262 262 LEU LEU M . n A 1 263 PRO 263 263 263 PRO PRO M . n A 1 264 TYR 264 264 264 TYR TYR M . n A 1 265 ASN 265 265 265 ASN ASN M . n A 1 266 ASP 266 266 266 ASP ASP M . n A 1 267 THR 267 267 267 THR THR M . n A 1 268 ASP 268 268 268 ASP ASP M . n A 1 269 ARG 269 269 269 ARG ARG M . n A 1 270 HIS 270 270 270 HIS HIS M . n A 1 271 SER 271 271 271 SER SER M . n A 1 272 ILE 272 272 272 ILE ILE M . n A 1 273 ALA 273 273 273 ALA ALA M . n A 1 274 ALA 274 274 274 ALA ALA M . n A 1 275 THR 275 275 275 THR THR M . n A 1 276 GLU 276 276 276 GLU GLU M . n A 1 277 ARG 277 277 277 ARG ARG M . n A 1 278 MET 278 278 278 MET MET M . n A 1 279 LYS 279 279 279 LYS LYS M . n A 1 280 GLU 280 280 280 GLU GLU M . n A 1 281 PHE 281 281 281 PHE PHE M . n A 1 282 PHE 282 282 282 PHE PHE M . n A 1 283 LEU 283 283 283 LEU LEU M . n A 1 284 GLY 284 284 284 GLY GLY M . n A 1 285 TRP 285 285 285 TRP TRP M . n A 1 286 PHE 286 286 286 PHE PHE M . n A 1 287 MET 287 287 287 MET MET M . n A 1 288 GLY 288 288 288 GLY GLY M . n A 1 289 PRO 289 289 289 PRO PRO M . n A 1 290 LEU 290 290 290 LEU LEU M . n A 1 291 THR 291 291 291 THR THR M . n A 1 292 ASN 292 292 292 ASN ASN M . n A 1 293 GLY 293 293 293 GLY GLY M . n A 1 294 THR 294 294 294 THR THR M . n A 1 295 TYR 295 295 295 TYR TYR M . n A 1 296 PRO 296 296 296 PRO PRO M . n A 1 297 GLN 297 297 297 GLN GLN M . n A 1 298 ILE 298 298 298 ILE ILE M . n A 1 299 MET 299 299 299 MET MET M . n A 1 300 ILE 300 300 300 ILE ILE M . n A 1 301 ASP 301 301 301 ASP ASP M . n A 1 302 THR 302 302 302 THR THR M . n A 1 303 VAL 303 303 303 VAL VAL M . n A 1 304 GLY 304 304 304 GLY GLY M . n A 1 305 GLU 305 305 305 GLU GLU M . n A 1 306 ARG 306 306 306 ARG ARG M . n A 1 307 LEU 307 307 307 LEU LEU M . n A 1 308 PRO 308 308 308 PRO PRO M . n A 1 309 SER 309 309 309 SER SER M . n A 1 310 PHE 310 310 310 PHE PHE M . n A 1 311 SER 311 311 311 SER SER M . n A 1 312 PRO 312 312 312 PRO PRO M . n A 1 313 GLU 313 313 313 GLU GLU M . n A 1 314 GLU 314 314 314 GLU GLU M . n A 1 315 SER 315 315 315 SER SER M . n A 1 316 ASN 316 316 316 ASN ASN M . n A 1 317 LEU 317 317 317 LEU LEU M . n A 1 318 VAL 318 318 318 VAL VAL M . n A 1 319 LYS 319 319 319 LYS LYS M . n A 1 320 GLY 320 320 320 GLY GLY M . n A 1 321 SER 321 321 321 SER SER M . n A 1 322 TYR 322 322 322 TYR TYR M . n A 1 323 ASP 323 323 323 ASP ASP M . n A 1 324 PHE 324 324 324 PHE PHE M . n A 1 325 LEU 325 325 325 LEU LEU M . n A 1 326 GLY 326 326 326 GLY GLY M . n A 1 327 LEU 327 327 327 LEU LEU M . n A 1 328 ASN 328 328 328 ASN ASN M . n A 1 329 TYR 329 329 329 TYR TYR M . n A 1 330 TYR 330 330 330 TYR TYR M . n A 1 331 PHE 331 331 331 PHE PHE M . n A 1 332 THR 332 332 332 THR THR M . n A 1 333 GLN 333 333 333 GLN GLN M . n A 1 334 TYR 334 334 334 TYR TYR M . n A 1 335 ALA 335 335 335 ALA ALA M . n A 1 336 GLN 336 336 336 GLN GLN M . n A 1 337 PRO 337 337 337 PRO PRO M . n A 1 338 SER 338 338 338 SER SER M . n A 1 339 PRO 339 339 339 PRO PRO M . n A 1 340 ASN 340 340 340 ASN ASN M . n A 1 341 PRO 341 341 341 PRO PRO M . n A 1 342 VAL 342 342 342 VAL VAL M . n A 1 343 ASN 343 343 343 ASN ASN M . n A 1 344 SER 344 344 344 SER SER M . n A 1 345 THR 345 345 345 THR THR M . n A 1 346 ASN 346 346 346 ASN ASN M . n A 1 347 HIS 347 347 347 HIS HIS M . n A 1 348 THR 348 348 348 THR THR M . n A 1 349 ALA 349 349 349 ALA ALA M . n A 1 350 MET 350 350 350 MET MET M . n A 1 351 MET 351 351 351 MET MET M . n A 1 352 ASP 352 352 352 ASP ASP M . n A 1 353 ALA 353 353 353 ALA ALA M . n A 1 354 GLY 354 354 354 GLY GLY M . n A 1 355 ALA 355 355 355 ALA ALA M . n A 1 356 LYS 356 356 356 LYS LYS M . n A 1 357 LEU 357 357 357 LEU LEU M . n A 1 358 THR 358 358 358 THR THR M . n A 1 359 TYR 359 359 359 TYR TYR M . n A 1 360 ILE 360 360 360 ILE ILE M . n A 1 361 ASN 361 361 361 ASN ASN M . n A 1 362 ALA 362 362 362 ALA ALA M . n A 1 363 SER 363 363 363 SER SER M . n A 1 364 GLY 364 364 364 GLY GLY M . n A 1 365 HIS 365 365 365 HIS HIS M . n A 1 366 TYR 366 366 366 TYR TYR M . n A 1 367 ILE 367 367 367 ILE ILE M . n A 1 368 GLY 368 368 368 GLY GLY M . n A 1 369 PRO 369 369 369 PRO PRO M . n A 1 370 LEU 370 370 370 LEU LEU M . n A 1 371 PHE 371 371 371 PHE PHE M . n A 1 372 GLU 372 372 372 GLU GLU M . n A 1 373 LYS 373 373 373 LYS LYS M . n A 1 374 ASP 374 374 374 ASP ASP M . n A 1 375 LYS 375 375 375 LYS LYS M . n A 1 376 ALA 376 376 376 ALA ALA M . n A 1 377 ASP 377 377 377 ASP ASP M . n A 1 378 SER 378 378 378 SER SER M . n A 1 379 THR 379 379 379 THR THR M . n A 1 380 ASP 380 380 380 ASP ASP M . n A 1 381 ASN 381 381 381 ASN ASN M . n A 1 382 ILE 382 382 382 ILE ILE M . n A 1 383 TYR 383 383 383 TYR TYR M . n A 1 384 TYR 384 384 384 TYR TYR M . n A 1 385 TYR 385 385 385 TYR TYR M . n A 1 386 PRO 386 386 386 PRO PRO M . n A 1 387 LYS 387 387 387 LYS LYS M . n A 1 388 GLY 388 388 388 GLY GLY M . n A 1 389 ILE 389 389 389 ILE ILE M . n A 1 390 TYR 390 390 390 TYR TYR M . n A 1 391 SER 391 391 391 SER SER M . n A 1 392 VAL 392 392 392 VAL VAL M . n A 1 393 MET 393 393 393 MET MET M . n A 1 394 ASP 394 394 394 ASP ASP M . n A 1 395 TYR 395 395 395 TYR TYR M . n A 1 396 PHE 396 396 396 PHE PHE M . n A 1 397 LYS 397 397 397 LYS LYS M . n A 1 398 ASN 398 398 398 ASN ASN M . n A 1 399 LYS 399 399 399 LYS LYS M . n A 1 400 TYR 400 400 400 TYR TYR M . n A 1 401 TYR 401 401 401 TYR TYR M . n A 1 402 ASN 402 402 402 ASN ASN M . n A 1 403 PRO 403 403 403 PRO PRO M . n A 1 404 LEU 404 404 404 LEU LEU M . n A 1 405 ILE 405 405 405 ILE ILE M . n A 1 406 TYR 406 406 406 TYR TYR M . n A 1 407 VAL 407 407 407 VAL VAL M . n A 1 408 THR 408 408 408 THR THR M . n A 1 409 GLU 409 409 409 GLU GLU M . n A 1 410 ASN 410 410 410 ASN ASN M . n A 1 411 GLY 411 411 411 GLY GLY M . n A 1 412 ILE 412 412 412 ILE ILE M . n A 1 413 SER 413 413 413 SER SER M . n A 1 414 THR 414 414 414 THR THR M . n A 1 415 PRO 415 415 415 PRO PRO M . n A 1 416 GLY 416 416 416 GLY GLY M . n A 1 417 ASP 417 417 417 ASP ASP M . n A 1 418 GLU 418 418 418 GLU GLU M . n A 1 419 ASN 419 419 419 ASN ASN M . n A 1 420 ARG 420 420 420 ARG ARG M . n A 1 421 ASN 421 421 421 ASN ASN M . n A 1 422 GLN 422 422 422 GLN GLN M . n A 1 423 SER 423 423 423 SER SER M . n A 1 424 MET 424 424 424 MET MET M . n A 1 425 LEU 425 425 425 LEU LEU M . n A 1 426 ASP 426 426 426 ASP ASP M . n A 1 427 TYR 427 427 427 TYR TYR M . n A 1 428 THR 428 428 428 THR THR M . n A 1 429 ARG 429 429 429 ARG ARG M . n A 1 430 ILE 430 430 430 ILE ILE M . n A 1 431 ASP 431 431 431 ASP ASP M . n A 1 432 TYR 432 432 432 TYR TYR M . n A 1 433 LEU 433 433 433 LEU LEU M . n A 1 434 CYS 434 434 434 CYS CYS M . n A 1 435 SER 435 435 435 SER SER M . n A 1 436 HIS 436 436 436 HIS HIS M . n A 1 437 LEU 437 437 437 LEU LEU M . n A 1 438 CYS 438 438 438 CYS CYS M . n A 1 439 PHE 439 439 439 PHE PHE M . n A 1 440 LEU 440 440 440 LEU LEU M . n A 1 441 ASN 441 441 441 ASN ASN M . n A 1 442 LYS 442 442 442 LYS LYS M . n A 1 443 VAL 443 443 443 VAL VAL M . n A 1 444 ILE 444 444 444 ILE ILE M . n A 1 445 LYS 445 445 445 LYS LYS M . n A 1 446 GLU 446 446 446 GLU GLU M . n A 1 447 LYS 447 447 447 LYS LYS M . n A 1 448 ASP 448 448 448 ASP ASP M . n A 1 449 VAL 449 449 449 VAL VAL M . n A 1 450 ASN 450 450 450 ASN ASN M . n A 1 451 VAL 451 451 451 VAL VAL M . n A 1 452 LYS 452 452 452 LYS LYS M . n A 1 453 GLY 453 453 453 GLY GLY M . n A 1 454 TYR 454 454 454 TYR TYR M . n A 1 455 LEU 455 455 455 LEU LEU M . n A 1 456 ALA 456 456 456 ALA ALA M . n A 1 457 TRP 457 457 457 TRP TRP M . n A 1 458 ALA 458 458 458 ALA ALA M . n A 1 459 LEU 459 459 459 LEU LEU M . n A 1 460 GLY 460 460 460 GLY GLY M . n A 1 461 ASP 461 461 461 ASP ASP M . n A 1 462 ASN 462 462 462 ASN ASN M . n A 1 463 TYR 463 463 463 TYR TYR M . n A 1 464 GLU 464 464 464 GLU GLU M . n A 1 465 PHE 465 465 465 PHE PHE M . n A 1 466 ASN 466 466 466 ASN ASN M . n A 1 467 LYS 467 467 467 LYS LYS M . n A 1 468 GLY 468 468 468 GLY GLY M . n A 1 469 PHE 469 469 469 PHE PHE M . n A 1 470 THR 470 470 470 THR THR M . n A 1 471 VAL 471 471 471 VAL VAL M . n A 1 472 ARG 472 472 472 ARG ARG M . n A 1 473 PHE 473 473 473 PHE PHE M . n A 1 474 GLY 474 474 474 GLY GLY M . n A 1 475 LEU 475 475 475 LEU LEU M . n A 1 476 SER 476 476 476 SER SER M . n A 1 477 TYR 477 477 477 TYR TYR M . n A 1 478 ILE 478 478 478 ILE ILE M . n A 1 479 ASP 479 479 479 ASP ASP M . n A 1 480 TRP 480 480 480 TRP TRP M . n A 1 481 ASN 481 481 481 ASN ASN M . n A 1 482 ASN 482 482 482 ASN ASN M . n A 1 483 VAL 483 483 483 VAL VAL M . n A 1 484 THR 484 484 484 THR THR M . n A 1 485 ASP 485 485 485 ASP ASP M . n A 1 486 ARG 486 486 486 ARG ARG M . n A 1 487 ASP 487 487 487 ASP ASP M . n A 1 488 LEU 488 488 488 LEU LEU M . n A 1 489 LYS 489 489 489 LYS LYS M . n A 1 490 LYS 490 490 490 LYS LYS M . n A 1 491 SER 491 491 491 SER SER M . n A 1 492 GLY 492 492 492 GLY GLY M . n A 1 493 GLN 493 493 493 GLN GLN M . n A 1 494 TRP 494 494 494 TRP TRP M . n A 1 495 TYR 495 495 495 TYR TYR M . n A 1 496 GLN 496 496 496 GLN GLN M . n A 1 497 SER 497 497 497 SER SER M . n A 1 498 PHE 498 498 498 PHE PHE M . n A 1 499 ILE 499 499 499 ILE ILE M . n A 1 500 SER 500 500 500 SER SER M . n A 1 501 PRO 501 501 501 PRO PRO M . n # loop_ _pdbx_nonpoly_scheme.asym_id _pdbx_nonpoly_scheme.entity_id _pdbx_nonpoly_scheme.mon_id _pdbx_nonpoly_scheme.ndb_seq_num _pdbx_nonpoly_scheme.pdb_seq_num _pdbx_nonpoly_scheme.auth_seq_num _pdbx_nonpoly_scheme.pdb_mon_id _pdbx_nonpoly_scheme.auth_mon_id _pdbx_nonpoly_scheme.pdb_strand_id _pdbx_nonpoly_scheme.pdb_ins_code B 2 NAG 1 901 901 NAG NAG M . C 2 NAG 1 911 911 NAG NAG M . D 2 NAG 1 921 921 NAG NAG M . E 2 NAG 2 923 923 NAG NAG M . F 2 NAG 1 931 931 NAG NAG M . G 2 NAG 1 941 941 NAG NAG M . H 3 FUC 2 942 942 FUC FUC M . I 2 NAG 3 943 943 NAG NAG M . J 4 BMA 4 944 944 BMA BMA M . K 5 XYP 5 945 945 XYP XYP M . L 2 NAG 1 951 951 NAG NAG M . M 3 FUC 2 952 952 FUC FUC M . N 2 NAG 3 953 953 NAG NAG M . O 4 BMA 4 954 954 BMA BMA M . P 5 XYP 5 955 955 XYP XYP M . Q 6 MAN 6 956 956 MAN MAN M . R 6 MAN 7 957 957 MAN MAN M . S 2 NAG 1 961 961 NAG NAG M . T 2 NAG 1 971 971 NAG NAG M . U 2 NAG 1 981 981 NAG NAG M . V 2 NAG 2 983 983 NAG NAG M . W 2 NAG 1 991 991 NAG NAG M . X 7 CGT 1 999 999 CGT CGT M . Y 8 GOL 1 1000 1000 GOL GOL M . Z 9 ZN 1 1502 1502 ZN ZN M . AA 10 SO4 1 1503 1503 SO4 SO4 M . BA 10 SO4 1 1504 1504 SO4 SO4 M . CA 10 SO4 1 1505 1505 SO4 SO4 M . DA 10 SO4 1 1506 1506 SO4 SO4 M . EA 8 GOL 1 1512 1512 GOL GOL M . FA 8 GOL 1 1513 1513 GOL GOL M . GA 11 HOH 1 2001 2001 HOH HOH M . GA 11 HOH 2 2002 2002 HOH HOH M . GA 11 HOH 3 2003 2003 HOH HOH M . GA 11 HOH 4 2004 2004 HOH HOH M . GA 11 HOH 5 2005 2005 HOH HOH M . GA 11 HOH 6 2006 2006 HOH HOH M . GA 11 HOH 7 2007 2007 HOH HOH M . GA 11 HOH 8 2008 2008 HOH HOH M . GA 11 HOH 9 2009 2009 HOH HOH M . GA 11 HOH 10 2010 2010 HOH HOH M . GA 11 HOH 11 2011 2011 HOH HOH M . GA 11 HOH 12 2012 2012 HOH HOH M . GA 11 HOH 13 2013 2013 HOH HOH M . GA 11 HOH 14 2014 2014 HOH HOH M . GA 11 HOH 15 2015 2015 HOH HOH M . GA 11 HOH 16 2016 2016 HOH HOH M . GA 11 HOH 17 2017 2017 HOH HOH M . GA 11 HOH 18 2018 2018 HOH HOH M . GA 11 HOH 19 2019 2019 HOH HOH M . GA 11 HOH 20 2020 2020 HOH HOH M . GA 11 HOH 21 2021 2021 HOH HOH M . GA 11 HOH 22 2022 2022 HOH HOH M . GA 11 HOH 23 2023 2023 HOH HOH M . GA 11 HOH 24 2024 2024 HOH HOH M . GA 11 HOH 25 2025 2025 HOH HOH M . GA 11 HOH 26 2026 2026 HOH HOH M . GA 11 HOH 27 2027 2027 HOH HOH M . GA 11 HOH 28 2028 2028 HOH HOH M . GA 11 HOH 29 2029 2029 HOH HOH M . GA 11 HOH 30 2030 2030 HOH HOH M . GA 11 HOH 31 2031 2031 HOH HOH M . GA 11 HOH 32 2032 2032 HOH HOH M . GA 11 HOH 33 2033 2033 HOH HOH M . GA 11 HOH 34 2034 2034 HOH HOH M . GA 11 HOH 35 2035 2035 HOH HOH M . GA 11 HOH 36 2036 2036 HOH HOH M . GA 11 HOH 37 2037 2037 HOH HOH M . GA 11 HOH 38 2038 2038 HOH HOH M . GA 11 HOH 39 2039 2039 HOH HOH M . GA 11 HOH 40 2040 2040 HOH HOH M . GA 11 HOH 41 2041 2041 HOH HOH M . GA 11 HOH 42 2042 2042 HOH HOH M . GA 11 HOH 43 2043 2043 HOH HOH M . GA 11 HOH 44 2044 2044 HOH HOH M . GA 11 HOH 45 2045 2045 HOH HOH M . GA 11 HOH 46 2046 2046 HOH HOH M . GA 11 HOH 47 2047 2047 HOH HOH M . GA 11 HOH 48 2048 2048 HOH HOH M . GA 11 HOH 49 2049 2049 HOH HOH M . GA 11 HOH 50 2050 2050 HOH HOH M . GA 11 HOH 51 2051 2051 HOH HOH M . GA 11 HOH 52 2052 2052 HOH HOH M . GA 11 HOH 53 2053 2053 HOH HOH M . GA 11 HOH 54 2054 2054 HOH HOH M . GA 11 HOH 55 2055 2055 HOH HOH M . GA 11 HOH 56 2056 2056 HOH HOH M . GA 11 HOH 57 2057 2057 HOH HOH M . GA 11 HOH 58 2058 2058 HOH HOH M . GA 11 HOH 59 2059 2059 HOH HOH M . GA 11 HOH 60 2060 2060 HOH HOH M . GA 11 HOH 61 2061 2061 HOH HOH M . GA 11 HOH 62 2062 2062 HOH HOH M . GA 11 HOH 63 2063 2063 HOH HOH M . GA 11 HOH 64 2064 2064 HOH HOH M . GA 11 HOH 65 2065 2065 HOH HOH M . GA 11 HOH 66 2066 2066 HOH HOH M . GA 11 HOH 67 2067 2067 HOH HOH M . GA 11 HOH 68 2068 2068 HOH HOH M . GA 11 HOH 69 2069 2069 HOH HOH M . GA 11 HOH 70 2070 2070 HOH HOH M . GA 11 HOH 71 2071 2071 HOH HOH M . GA 11 HOH 72 2072 2072 HOH HOH M . GA 11 HOH 73 2073 2073 HOH HOH M . GA 11 HOH 74 2074 2074 HOH HOH M . GA 11 HOH 75 2075 2075 HOH HOH M . GA 11 HOH 76 2076 2076 HOH HOH M . GA 11 HOH 77 2077 2077 HOH HOH M . GA 11 HOH 78 2078 2078 HOH HOH M . GA 11 HOH 79 2079 2079 HOH HOH M . GA 11 HOH 80 2080 2080 HOH HOH M . GA 11 HOH 81 2081 2081 HOH HOH M . GA 11 HOH 82 2082 2082 HOH HOH M . GA 11 HOH 83 2083 2083 HOH HOH M . GA 11 HOH 84 2084 2084 HOH HOH M . GA 11 HOH 85 2085 2085 HOH HOH M . GA 11 HOH 86 2086 2086 HOH HOH M . GA 11 HOH 87 2087 2087 HOH HOH M . GA 11 HOH 88 2088 2088 HOH HOH M . GA 11 HOH 89 2089 2089 HOH HOH M . GA 11 HOH 90 2090 2090 HOH HOH M . GA 11 HOH 91 2091 2091 HOH HOH M . GA 11 HOH 92 2092 2092 HOH HOH M . GA 11 HOH 93 2093 2093 HOH HOH M . GA 11 HOH 94 2094 2094 HOH HOH M . GA 11 HOH 95 2095 2095 HOH HOH M . GA 11 HOH 96 2096 2096 HOH HOH M . GA 11 HOH 97 2097 2097 HOH HOH M . GA 11 HOH 98 2098 2098 HOH HOH M . GA 11 HOH 99 2099 2099 HOH HOH M . GA 11 HOH 100 2100 2100 HOH HOH M . GA 11 HOH 101 2101 2101 HOH HOH M . GA 11 HOH 102 2102 2102 HOH HOH M . GA 11 HOH 103 2103 2103 HOH HOH M . GA 11 HOH 104 2104 2104 HOH HOH M . GA 11 HOH 105 2105 2105 HOH HOH M . GA 11 HOH 106 2106 2106 HOH HOH M . GA 11 HOH 107 2107 2107 HOH HOH M . GA 11 HOH 108 2108 2108 HOH HOH M . GA 11 HOH 109 2109 2109 HOH HOH M . GA 11 HOH 110 2110 2110 HOH HOH M . GA 11 HOH 111 2111 2111 HOH HOH M . GA 11 HOH 112 2112 2112 HOH HOH M . GA 11 HOH 113 2113 2113 HOH HOH M . GA 11 HOH 114 2114 2114 HOH HOH M . GA 11 HOH 115 2115 2115 HOH HOH M . GA 11 HOH 116 2116 2116 HOH HOH M . GA 11 HOH 117 2117 2117 HOH HOH M . GA 11 HOH 118 2118 2118 HOH HOH M . GA 11 HOH 119 2119 2119 HOH HOH M . GA 11 HOH 120 2120 2120 HOH HOH M . GA 11 HOH 121 2121 2121 HOH HOH M . GA 11 HOH 122 2122 2122 HOH HOH M . GA 11 HOH 123 2123 2123 HOH HOH M . GA 11 HOH 124 2124 2124 HOH HOH M . GA 11 HOH 125 2125 2125 HOH HOH M . GA 11 HOH 126 2126 2126 HOH HOH M . GA 11 HOH 127 2127 2127 HOH HOH M . GA 11 HOH 128 2128 2128 HOH HOH M . GA 11 HOH 129 2129 2129 HOH HOH M . GA 11 HOH 130 2130 2130 HOH HOH M . GA 11 HOH 131 2131 2131 HOH HOH M . GA 11 HOH 132 2132 2132 HOH HOH M . GA 11 HOH 133 2133 2133 HOH HOH M . GA 11 HOH 134 2134 2134 HOH HOH M . GA 11 HOH 135 2135 2135 HOH HOH M . GA 11 HOH 136 2136 2136 HOH HOH M . GA 11 HOH 137 2137 2137 HOH HOH M . GA 11 HOH 138 2138 2138 HOH HOH M . GA 11 HOH 139 2139 2139 HOH HOH M . GA 11 HOH 140 2140 2140 HOH HOH M . GA 11 HOH 141 2141 2141 HOH HOH M . GA 11 HOH 142 2142 2142 HOH HOH M . GA 11 HOH 143 2143 2143 HOH HOH M . GA 11 HOH 144 2144 2144 HOH HOH M . GA 11 HOH 145 2145 2145 HOH HOH M . GA 11 HOH 146 2146 2146 HOH HOH M . GA 11 HOH 147 2147 2147 HOH HOH M . GA 11 HOH 148 2148 2148 HOH HOH M . GA 11 HOH 149 2149 2149 HOH HOH M . GA 11 HOH 150 2150 2150 HOH HOH M . GA 11 HOH 151 2151 2151 HOH HOH M . GA 11 HOH 152 2152 2152 HOH HOH M . GA 11 HOH 153 2153 2153 HOH HOH M . GA 11 HOH 154 2154 2154 HOH HOH M . GA 11 HOH 155 2155 2155 HOH HOH M . GA 11 HOH 156 2156 2156 HOH HOH M . GA 11 HOH 157 2157 2157 HOH HOH M . GA 11 HOH 158 2158 2158 HOH HOH M . GA 11 HOH 159 2159 2159 HOH HOH M . GA 11 HOH 160 2160 2160 HOH HOH M . GA 11 HOH 161 2161 2161 HOH HOH M . GA 11 HOH 162 2162 2162 HOH HOH M . GA 11 HOH 163 2163 2163 HOH HOH M . GA 11 HOH 164 2164 2164 HOH HOH M . GA 11 HOH 165 2165 2165 HOH HOH M . GA 11 HOH 166 2166 2166 HOH HOH M . GA 11 HOH 167 2167 2167 HOH HOH M . GA 11 HOH 168 2168 2168 HOH HOH M . GA 11 HOH 169 2169 2169 HOH HOH M . GA 11 HOH 170 2170 2170 HOH HOH M . GA 11 HOH 171 2171 2171 HOH HOH M . GA 11 HOH 172 2172 2172 HOH HOH M . GA 11 HOH 173 2173 2173 HOH HOH M . GA 11 HOH 174 2174 2174 HOH HOH M . GA 11 HOH 175 2175 2175 HOH HOH M . GA 11 HOH 176 2176 2176 HOH HOH M . GA 11 HOH 177 2177 2177 HOH HOH M . GA 11 HOH 178 2178 2178 HOH HOH M . GA 11 HOH 179 2179 2179 HOH HOH M . GA 11 HOH 180 2180 2180 HOH HOH M . GA 11 HOH 181 2181 2181 HOH HOH M . GA 11 HOH 182 2182 2182 HOH HOH M . GA 11 HOH 183 2183 2183 HOH HOH M . GA 11 HOH 184 2184 2184 HOH HOH M . GA 11 HOH 185 2185 2185 HOH HOH M . GA 11 HOH 186 2186 2186 HOH HOH M . GA 11 HOH 187 2187 2187 HOH HOH M . GA 11 HOH 188 2188 2188 HOH HOH M . GA 11 HOH 189 2189 2189 HOH HOH M . GA 11 HOH 190 2190 2190 HOH HOH M . GA 11 HOH 191 2191 2191 HOH HOH M . GA 11 HOH 192 2192 2192 HOH HOH M . GA 11 HOH 193 2193 2193 HOH HOH M . GA 11 HOH 194 2194 2194 HOH HOH M . GA 11 HOH 195 2195 2195 HOH HOH M . GA 11 HOH 196 2196 2196 HOH HOH M . GA 11 HOH 197 2197 2197 HOH HOH M . GA 11 HOH 198 2198 2198 HOH HOH M . GA 11 HOH 199 2199 2199 HOH HOH M . GA 11 HOH 200 2200 2200 HOH HOH M . GA 11 HOH 201 2201 2201 HOH HOH M . GA 11 HOH 202 2202 2202 HOH HOH M . GA 11 HOH 203 2203 2203 HOH HOH M . GA 11 HOH 204 2204 2204 HOH HOH M . GA 11 HOH 205 2205 2205 HOH HOH M . GA 11 HOH 206 2206 2206 HOH HOH M . GA 11 HOH 207 2207 2207 HOH HOH M . GA 11 HOH 208 2208 2208 HOH HOH M . GA 11 HOH 209 2209 2209 HOH HOH M . GA 11 HOH 210 2210 2210 HOH HOH M . GA 11 HOH 211 2211 2211 HOH HOH M . GA 11 HOH 212 2212 2212 HOH HOH M . GA 11 HOH 213 2213 2213 HOH HOH M . GA 11 HOH 214 2214 2214 HOH HOH M . GA 11 HOH 215 2215 2215 HOH HOH M . GA 11 HOH 216 2216 2216 HOH HOH M . GA 11 HOH 217 2217 2217 HOH HOH M . GA 11 HOH 218 2218 2218 HOH HOH M . GA 11 HOH 219 2219 2219 HOH HOH M . GA 11 HOH 220 2220 2220 HOH HOH M . GA 11 HOH 221 2221 2221 HOH HOH M . GA 11 HOH 222 2222 2222 HOH HOH M . GA 11 HOH 223 2223 2223 HOH HOH M . GA 11 HOH 224 2224 2224 HOH HOH M . GA 11 HOH 225 2225 2225 HOH HOH M . GA 11 HOH 226 2226 2226 HOH HOH M . GA 11 HOH 227 2227 2227 HOH HOH M . GA 11 HOH 228 2228 2228 HOH HOH M . GA 11 HOH 229 2229 2229 HOH HOH M . GA 11 HOH 230 2230 2230 HOH HOH M . GA 11 HOH 231 2231 2231 HOH HOH M . GA 11 HOH 232 2232 2232 HOH HOH M . GA 11 HOH 233 2233 2233 HOH HOH M . GA 11 HOH 234 2234 2234 HOH HOH M . GA 11 HOH 235 2235 2235 HOH HOH M . GA 11 HOH 236 2236 2236 HOH HOH M . GA 11 HOH 237 2237 2237 HOH HOH M . GA 11 HOH 238 2238 2238 HOH HOH M . GA 11 HOH 239 2239 2239 HOH HOH M . GA 11 HOH 240 2240 2240 HOH HOH M . GA 11 HOH 241 2241 2241 HOH HOH M . GA 11 HOH 242 2242 2242 HOH HOH M . GA 11 HOH 243 2243 2243 HOH HOH M . GA 11 HOH 244 2244 2244 HOH HOH M . GA 11 HOH 245 2245 2245 HOH HOH M . GA 11 HOH 246 2246 2246 HOH HOH M . GA 11 HOH 247 2247 2247 HOH HOH M . GA 11 HOH 248 2248 2248 HOH HOH M . GA 11 HOH 249 2249 2249 HOH HOH M . GA 11 HOH 250 2250 2250 HOH HOH M . GA 11 HOH 251 2251 2251 HOH HOH M . GA 11 HOH 252 2252 2252 HOH HOH M . GA 11 HOH 253 2253 2253 HOH HOH M . GA 11 HOH 254 2254 2254 HOH HOH M . GA 11 HOH 255 2255 2255 HOH HOH M . GA 11 HOH 256 2256 2256 HOH HOH M . GA 11 HOH 257 2257 2257 HOH HOH M . GA 11 HOH 258 2258 2258 HOH HOH M . GA 11 HOH 259 2259 2259 HOH HOH M . GA 11 HOH 260 2260 2260 HOH HOH M . GA 11 HOH 261 2261 2261 HOH HOH M . GA 11 HOH 262 2262 2262 HOH HOH M . GA 11 HOH 263 2263 2263 HOH HOH M . GA 11 HOH 264 2264 2264 HOH HOH M . GA 11 HOH 265 2265 2265 HOH HOH M . GA 11 HOH 266 2266 2266 HOH HOH M . GA 11 HOH 267 2267 2267 HOH HOH M . GA 11 HOH 268 2268 2268 HOH HOH M . GA 11 HOH 269 2269 2269 HOH HOH M . GA 11 HOH 270 2270 2270 HOH HOH M . GA 11 HOH 271 2271 2271 HOH HOH M . GA 11 HOH 272 2272 2272 HOH HOH M . GA 11 HOH 273 2273 2273 HOH HOH M . GA 11 HOH 274 2274 2274 HOH HOH M . GA 11 HOH 275 2275 2275 HOH HOH M . GA 11 HOH 276 2276 2276 HOH HOH M . GA 11 HOH 277 2277 2277 HOH HOH M . GA 11 HOH 278 2278 2278 HOH HOH M . GA 11 HOH 279 2279 2279 HOH HOH M . GA 11 HOH 280 2280 2280 HOH HOH M . GA 11 HOH 281 2281 2281 HOH HOH M . GA 11 HOH 282 2282 2282 HOH HOH M . GA 11 HOH 283 2283 2283 HOH HOH M . GA 11 HOH 284 2284 2284 HOH HOH M . GA 11 HOH 285 2285 2285 HOH HOH M . GA 11 HOH 286 2286 2286 HOH HOH M . GA 11 HOH 287 2287 2287 HOH HOH M . GA 11 HOH 288 2288 2288 HOH HOH M . GA 11 HOH 289 2289 2289 HOH HOH M . GA 11 HOH 290 2290 2290 HOH HOH M . GA 11 HOH 291 2291 2291 HOH HOH M . GA 11 HOH 292 2292 2292 HOH HOH M . GA 11 HOH 293 2293 2293 HOH HOH M . GA 11 HOH 294 2294 2294 HOH HOH M . GA 11 HOH 295 2295 2295 HOH HOH M . GA 11 HOH 296 2296 2296 HOH HOH M . GA 11 HOH 297 2297 2297 HOH HOH M . GA 11 HOH 298 2298 2298 HOH HOH M . GA 11 HOH 299 2299 2299 HOH HOH M . GA 11 HOH 300 2300 2300 HOH HOH M . GA 11 HOH 301 2301 2301 HOH HOH M . GA 11 HOH 302 2302 2302 HOH HOH M . GA 11 HOH 303 2303 2303 HOH HOH M . GA 11 HOH 304 2304 2304 HOH HOH M . GA 11 HOH 305 2305 2305 HOH HOH M . GA 11 HOH 306 2306 2306 HOH HOH M . GA 11 HOH 307 2307 2307 HOH HOH M . GA 11 HOH 308 2308 2308 HOH HOH M . GA 11 HOH 309 2309 2309 HOH HOH M . GA 11 HOH 310 2310 2310 HOH HOH M . GA 11 HOH 311 2311 2311 HOH HOH M . GA 11 HOH 312 2312 2312 HOH HOH M . GA 11 HOH 313 2313 2313 HOH HOH M . GA 11 HOH 314 2314 2314 HOH HOH M . GA 11 HOH 315 2315 2315 HOH HOH M . GA 11 HOH 316 2316 2316 HOH HOH M . GA 11 HOH 317 2317 2317 HOH HOH M . GA 11 HOH 318 2318 2318 HOH HOH M . GA 11 HOH 319 2319 2319 HOH HOH M . GA 11 HOH 320 2320 2320 HOH HOH M . GA 11 HOH 321 2321 2321 HOH HOH M . GA 11 HOH 322 2322 2322 HOH HOH M . GA 11 HOH 323 2323 2323 HOH HOH M . GA 11 HOH 324 2324 2324 HOH HOH M . GA 11 HOH 325 2325 2325 HOH HOH M . GA 11 HOH 326 2326 2326 HOH HOH M . GA 11 HOH 327 2327 2327 HOH HOH M . GA 11 HOH 328 2328 2328 HOH HOH M . GA 11 HOH 329 2329 2329 HOH HOH M . GA 11 HOH 330 2330 2330 HOH HOH M . GA 11 HOH 331 2331 2331 HOH HOH M . GA 11 HOH 332 2332 2332 HOH HOH M . GA 11 HOH 333 2333 2333 HOH HOH M . GA 11 HOH 334 2334 2334 HOH HOH M . GA 11 HOH 335 2335 2335 HOH HOH M . GA 11 HOH 336 2336 2336 HOH HOH M . GA 11 HOH 337 2337 2337 HOH HOH M . GA 11 HOH 338 2338 2338 HOH HOH M . GA 11 HOH 339 2339 2339 HOH HOH M . GA 11 HOH 340 2340 2340 HOH HOH M . GA 11 HOH 341 2341 2341 HOH HOH M . GA 11 HOH 342 2342 2342 HOH HOH M . GA 11 HOH 343 2343 2343 HOH HOH M . GA 11 HOH 344 2344 2344 HOH HOH M . GA 11 HOH 345 2345 2345 HOH HOH M . GA 11 HOH 346 2346 2346 HOH HOH M . GA 11 HOH 347 2347 2347 HOH HOH M . GA 11 HOH 348 2348 2348 HOH HOH M . GA 11 HOH 349 2349 2349 HOH HOH M . GA 11 HOH 350 2350 2350 HOH HOH M . GA 11 HOH 351 2351 2351 HOH HOH M . GA 11 HOH 352 2352 2352 HOH HOH M . GA 11 HOH 353 2353 2353 HOH HOH M . GA 11 HOH 354 2354 2354 HOH HOH M . GA 11 HOH 355 2355 2355 HOH HOH M . GA 11 HOH 356 2356 2356 HOH HOH M . GA 11 HOH 357 2357 2357 HOH HOH M . GA 11 HOH 358 2358 2358 HOH HOH M . GA 11 HOH 359 2359 2359 HOH HOH M . GA 11 HOH 360 2360 2360 HOH HOH M . GA 11 HOH 361 2361 2361 HOH HOH M . GA 11 HOH 362 2362 2362 HOH HOH M . GA 11 HOH 363 2363 2363 HOH HOH M . GA 11 HOH 364 2364 2364 HOH HOH M . GA 11 HOH 365 2365 2365 HOH HOH M . GA 11 HOH 366 2366 2366 HOH HOH M . GA 11 HOH 367 2367 2367 HOH HOH M . GA 11 HOH 368 2368 2368 HOH HOH M . GA 11 HOH 369 2369 2369 HOH HOH M . GA 11 HOH 370 2370 2370 HOH HOH M . GA 11 HOH 371 2371 2371 HOH HOH M . GA 11 HOH 372 2372 2372 HOH HOH M . GA 11 HOH 373 2373 2373 HOH HOH M . GA 11 HOH 374 2374 2374 HOH HOH M . GA 11 HOH 375 2375 2375 HOH HOH M . GA 11 HOH 376 2376 2376 HOH HOH M . GA 11 HOH 377 2377 2377 HOH HOH M . GA 11 HOH 378 2378 2378 HOH HOH M . GA 11 HOH 379 2379 2379 HOH HOH M . GA 11 HOH 380 2380 2380 HOH HOH M . GA 11 HOH 381 2381 2381 HOH HOH M . GA 11 HOH 382 2382 2382 HOH HOH M . GA 11 HOH 383 2383 2383 HOH HOH M . GA 11 HOH 384 2384 2384 HOH HOH M . GA 11 HOH 385 2385 2385 HOH HOH M . GA 11 HOH 386 2386 2386 HOH HOH M . GA 11 HOH 387 2387 2387 HOH HOH M . GA 11 HOH 388 2388 2388 HOH HOH M . GA 11 HOH 389 2389 2389 HOH HOH M . GA 11 HOH 390 2390 2390 HOH HOH M . GA 11 HOH 391 2391 2391 HOH HOH M . GA 11 HOH 392 2392 2392 HOH HOH M . GA 11 HOH 393 2393 2393 HOH HOH M . GA 11 HOH 394 2394 2394 HOH HOH M . GA 11 HOH 395 2395 2395 HOH HOH M . GA 11 HOH 396 2396 2396 HOH HOH M . GA 11 HOH 397 2397 2397 HOH HOH M . GA 11 HOH 398 2398 2398 HOH HOH M . GA 11 HOH 399 2399 2399 HOH HOH M . GA 11 HOH 400 2400 2400 HOH HOH M . GA 11 HOH 401 2401 2401 HOH HOH M . GA 11 HOH 402 2402 2402 HOH HOH M . GA 11 HOH 403 2403 2403 HOH HOH M . GA 11 HOH 404 2404 2404 HOH HOH M . GA 11 HOH 405 2405 2405 HOH HOH M . GA 11 HOH 406 2406 2406 HOH HOH M . GA 11 HOH 407 2407 2407 HOH HOH M . GA 11 HOH 408 2408 2408 HOH HOH M . GA 11 HOH 409 2409 2409 HOH HOH M . GA 11 HOH 410 2410 2410 HOH HOH M . GA 11 HOH 411 2411 2411 HOH HOH M . GA 11 HOH 412 2412 2412 HOH HOH M . GA 11 HOH 413 2413 2413 HOH HOH M . GA 11 HOH 414 2414 2414 HOH HOH M . GA 11 HOH 415 2415 2415 HOH HOH M . GA 11 HOH 416 2416 2416 HOH HOH M . GA 11 HOH 417 2417 2417 HOH HOH M . GA 11 HOH 418 2418 2418 HOH HOH M . GA 11 HOH 419 2419 2419 HOH HOH M . GA 11 HOH 420 2420 2420 HOH HOH M . GA 11 HOH 421 2421 2421 HOH HOH M . GA 11 HOH 422 2422 2422 HOH HOH M . GA 11 HOH 423 2423 2423 HOH HOH M . GA 11 HOH 424 2424 2424 HOH HOH M . GA 11 HOH 425 2425 2425 HOH HOH M . GA 11 HOH 426 2426 2426 HOH HOH M . GA 11 HOH 427 2427 2427 HOH HOH M . GA 11 HOH 428 2428 2428 HOH HOH M . GA 11 HOH 429 2429 2429 HOH HOH M . GA 11 HOH 430 2430 2430 HOH HOH M . GA 11 HOH 431 2431 2431 HOH HOH M . GA 11 HOH 432 2432 2432 HOH HOH M . GA 11 HOH 433 2433 2433 HOH HOH M . GA 11 HOH 434 2434 2434 HOH HOH M . GA 11 HOH 435 2435 2435 HOH HOH M . GA 11 HOH 436 2436 2436 HOH HOH M . GA 11 HOH 437 2437 2437 HOH HOH M . GA 11 HOH 438 2438 2438 HOH HOH M . GA 11 HOH 439 2439 2439 HOH HOH M . GA 11 HOH 440 2440 2440 HOH HOH M . GA 11 HOH 441 2441 2441 HOH HOH M . GA 11 HOH 442 2442 2442 HOH HOH M . GA 11 HOH 443 2443 2443 HOH HOH M . GA 11 HOH 444 2444 2444 HOH HOH M . GA 11 HOH 445 2445 2445 HOH HOH M . GA 11 HOH 446 2446 2446 HOH HOH M . GA 11 HOH 447 2447 2447 HOH HOH M . GA 11 HOH 448 2448 2448 HOH HOH M . GA 11 HOH 449 2449 2449 HOH HOH M . GA 11 HOH 450 2450 2450 HOH HOH M . GA 11 HOH 451 2451 2451 HOH HOH M . GA 11 HOH 452 2452 2452 HOH HOH M . GA 11 HOH 453 2453 2453 HOH HOH M . GA 11 HOH 454 2454 2454 HOH HOH M . GA 11 HOH 455 2455 2455 HOH HOH M . GA 11 HOH 456 2456 2456 HOH HOH M . GA 11 HOH 457 2457 2457 HOH HOH M . GA 11 HOH 458 2458 2458 HOH HOH M . GA 11 HOH 459 2459 2459 HOH HOH M . GA 11 HOH 460 2460 2460 HOH HOH M . GA 11 HOH 461 2461 2461 HOH HOH M . GA 11 HOH 462 2462 2462 HOH HOH M . GA 11 HOH 463 2463 2463 HOH HOH M . GA 11 HOH 464 2464 2464 HOH HOH M . GA 11 HOH 465 2465 2465 HOH HOH M . GA 11 HOH 466 2466 2466 HOH HOH M . GA 11 HOH 467 2467 2467 HOH HOH M . GA 11 HOH 468 2468 2468 HOH HOH M . GA 11 HOH 469 2469 2469 HOH HOH M . GA 11 HOH 470 2470 2470 HOH HOH M . GA 11 HOH 471 2471 2471 HOH HOH M . GA 11 HOH 472 2472 2472 HOH HOH M . GA 11 HOH 473 2473 2473 HOH HOH M . GA 11 HOH 474 2474 2474 HOH HOH M . GA 11 HOH 475 2475 2475 HOH HOH M . GA 11 HOH 476 2476 2476 HOH HOH M . GA 11 HOH 477 2477 2477 HOH HOH M . GA 11 HOH 478 2478 2478 HOH HOH M . GA 11 HOH 479 2479 2479 HOH HOH M . GA 11 HOH 480 2480 2480 HOH HOH M . GA 11 HOH 481 2481 2481 HOH HOH M . GA 11 HOH 482 2482 2482 HOH HOH M . GA 11 HOH 483 2483 2483 HOH HOH M . GA 11 HOH 484 2484 2484 HOH HOH M . GA 11 HOH 485 2485 2485 HOH HOH M . GA 11 HOH 486 2486 2486 HOH HOH M . GA 11 HOH 487 2487 2487 HOH HOH M . GA 11 HOH 488 2488 2488 HOH HOH M . GA 11 HOH 489 2489 2489 HOH HOH M . GA 11 HOH 490 2490 2490 HOH HOH M . GA 11 HOH 491 2491 2491 HOH HOH M . GA 11 HOH 492 2492 2492 HOH HOH M . GA 11 HOH 493 2493 2493 HOH HOH M . GA 11 HOH 494 2494 2494 HOH HOH M . GA 11 HOH 495 2495 2495 HOH HOH M . GA 11 HOH 496 2496 2496 HOH HOH M . GA 11 HOH 497 2497 2497 HOH HOH M . GA 11 HOH 498 2498 2498 HOH HOH M . GA 11 HOH 499 2499 2499 HOH HOH M . GA 11 HOH 500 2500 2500 HOH HOH M . GA 11 HOH 501 2501 2501 HOH HOH M . GA 11 HOH 502 2502 2502 HOH HOH M . GA 11 HOH 503 2503 2503 HOH HOH M . GA 11 HOH 504 2504 2504 HOH HOH M . GA 11 HOH 505 2505 2505 HOH HOH M . GA 11 HOH 506 2506 2506 HOH HOH M . GA 11 HOH 507 2507 2507 HOH HOH M . GA 11 HOH 508 2508 2508 HOH HOH M . GA 11 HOH 509 2509 2509 HOH HOH M . GA 11 HOH 510 2510 2510 HOH HOH M . GA 11 HOH 511 2511 2511 HOH HOH M . GA 11 HOH 512 2512 2512 HOH HOH M . GA 11 HOH 513 2513 2513 HOH HOH M . GA 11 HOH 514 2514 2514 HOH HOH M . GA 11 HOH 515 2515 2515 HOH HOH M . GA 11 HOH 516 2516 2516 HOH HOH M . GA 11 HOH 517 2517 2517 HOH HOH M . GA 11 HOH 518 2518 2518 HOH HOH M . GA 11 HOH 519 2519 2519 HOH HOH M . GA 11 HOH 520 2520 2520 HOH HOH M . GA 11 HOH 521 2521 2521 HOH HOH M . GA 11 HOH 522 2522 2522 HOH HOH M . GA 11 HOH 523 2523 2523 HOH HOH M . GA 11 HOH 524 2524 2524 HOH HOH M . GA 11 HOH 525 2525 2525 HOH HOH M . GA 11 HOH 526 2526 2526 HOH HOH M . GA 11 HOH 527 2527 2527 HOH HOH M . GA 11 HOH 528 2528 2528 HOH HOH M . GA 11 HOH 529 2529 2529 HOH HOH M . GA 11 HOH 530 2530 2530 HOH HOH M . GA 11 HOH 531 2531 2531 HOH HOH M . GA 11 HOH 532 2532 2532 HOH HOH M . GA 11 HOH 533 2533 2533 HOH HOH M . GA 11 HOH 534 2534 2534 HOH HOH M . GA 11 HOH 535 2535 2535 HOH HOH M . GA 11 HOH 536 2536 2536 HOH HOH M . GA 11 HOH 537 2537 2537 HOH HOH M . GA 11 HOH 538 2538 2538 HOH HOH M . GA 11 HOH 539 2539 2539 HOH HOH M . GA 11 HOH 540 2540 2540 HOH HOH M . GA 11 HOH 541 2541 2541 HOH HOH M . GA 11 HOH 542 2542 2542 HOH HOH M . GA 11 HOH 543 2543 2543 HOH HOH M . GA 11 HOH 544 2544 2544 HOH HOH M . GA 11 HOH 545 2545 2545 HOH HOH M . GA 11 HOH 546 2546 2546 HOH HOH M . GA 11 HOH 547 2547 2547 HOH HOH M . GA 11 HOH 548 2548 2548 HOH HOH M . GA 11 HOH 549 2549 2549 HOH HOH M . GA 11 HOH 550 2550 2550 HOH HOH M . GA 11 HOH 551 2551 2551 HOH HOH M . GA 11 HOH 552 2552 2552 HOH HOH M . GA 11 HOH 553 2553 2553 HOH HOH M . GA 11 HOH 554 2554 2554 HOH HOH M . GA 11 HOH 555 2555 2555 HOH HOH M . GA 11 HOH 556 2556 2556 HOH HOH M . GA 11 HOH 557 2557 2557 HOH HOH M . GA 11 HOH 558 2558 2558 HOH HOH M . GA 11 HOH 559 2559 2559 HOH HOH M . GA 11 HOH 560 2560 2560 HOH HOH M . GA 11 HOH 561 2561 2561 HOH HOH M . GA 11 HOH 562 2562 2562 HOH HOH M . GA 11 HOH 563 2563 2563 HOH HOH M . GA 11 HOH 564 2564 2564 HOH HOH M . GA 11 HOH 565 2565 2565 HOH HOH M . GA 11 HOH 566 2566 2566 HOH HOH M . GA 11 HOH 567 2567 2567 HOH HOH M . GA 11 HOH 568 2568 2568 HOH HOH M . GA 11 HOH 569 2569 2569 HOH HOH M . GA 11 HOH 570 2570 2570 HOH HOH M . GA 11 HOH 571 2571 2571 HOH HOH M . GA 11 HOH 572 2572 2572 HOH HOH M . GA 11 HOH 573 2573 2573 HOH HOH M . GA 11 HOH 574 2574 2574 HOH HOH M . GA 11 HOH 575 2575 2575 HOH HOH M . GA 11 HOH 576 2576 2576 HOH HOH M . GA 11 HOH 577 2577 2577 HOH HOH M . GA 11 HOH 578 2578 2578 HOH HOH M . GA 11 HOH 579 2579 2579 HOH HOH M . GA 11 HOH 580 2580 2580 HOH HOH M . GA 11 HOH 581 2581 2581 HOH HOH M . GA 11 HOH 582 2582 2582 HOH HOH M . GA 11 HOH 583 2583 2583 HOH HOH M . GA 11 HOH 584 2584 2584 HOH HOH M . GA 11 HOH 585 2585 2585 HOH HOH M . GA 11 HOH 586 2586 2586 HOH HOH M . GA 11 HOH 587 2587 2587 HOH HOH M . GA 11 HOH 588 2588 2588 HOH HOH M . GA 11 HOH 589 2589 2589 HOH HOH M . GA 11 HOH 590 2590 2590 HOH HOH M . GA 11 HOH 591 2591 2591 HOH HOH M . GA 11 HOH 592 2592 2592 HOH HOH M . GA 11 HOH 593 2593 2593 HOH HOH M . GA 11 HOH 594 2594 2594 HOH HOH M . GA 11 HOH 595 2595 2595 HOH HOH M . GA 11 HOH 596 2596 2596 HOH HOH M . GA 11 HOH 597 2597 2597 HOH HOH M . GA 11 HOH 598 2598 2598 HOH HOH M . GA 11 HOH 599 2599 2599 HOH HOH M . GA 11 HOH 600 2600 2600 HOH HOH M . GA 11 HOH 601 2601 2601 HOH HOH M . GA 11 HOH 602 2602 2602 HOH HOH M . GA 11 HOH 603 2603 2603 HOH HOH M . GA 11 HOH 604 2604 2604 HOH HOH M . GA 11 HOH 605 2605 2605 HOH HOH M . GA 11 HOH 606 2606 2606 HOH HOH M . GA 11 HOH 607 2607 2607 HOH HOH M . GA 11 HOH 608 2608 2608 HOH HOH M . GA 11 HOH 609 2609 2609 HOH HOH M . GA 11 HOH 610 2610 2610 HOH HOH M . GA 11 HOH 611 2611 2611 HOH HOH M . GA 11 HOH 612 2612 2612 HOH HOH M . GA 11 HOH 613 2613 2613 HOH HOH M . GA 11 HOH 614 2614 2614 HOH HOH M . GA 11 HOH 615 2615 2615 HOH HOH M . GA 11 HOH 616 2616 2616 HOH HOH M . GA 11 HOH 617 2617 2617 HOH HOH M . GA 11 HOH 618 2618 2618 HOH HOH M . GA 11 HOH 619 2619 2619 HOH HOH M . GA 11 HOH 620 2620 2620 HOH HOH M . GA 11 HOH 621 2621 2621 HOH HOH M . GA 11 HOH 622 2622 2622 HOH HOH M . GA 11 HOH 623 2623 2623 HOH HOH M . GA 11 HOH 624 2624 2624 HOH HOH M . GA 11 HOH 625 2625 2625 HOH HOH M . GA 11 HOH 626 2626 2626 HOH HOH M . GA 11 HOH 627 2627 2627 HOH HOH M . GA 11 HOH 628 2628 2628 HOH HOH M . GA 11 HOH 629 2629 2629 HOH HOH M . GA 11 HOH 630 2630 2630 HOH HOH M . GA 11 HOH 631 2631 2631 HOH HOH M . GA 11 HOH 632 2632 2632 HOH HOH M . GA 11 HOH 633 2633 2633 HOH HOH M . GA 11 HOH 634 2634 2634 HOH HOH M . GA 11 HOH 635 2635 2635 HOH HOH M . GA 11 HOH 636 2636 2636 HOH HOH M . GA 11 HOH 637 2637 2637 HOH HOH M . GA 11 HOH 638 2638 2638 HOH HOH M . GA 11 HOH 639 2639 2639 HOH HOH M . GA 11 HOH 640 2640 2640 HOH HOH M . GA 11 HOH 641 2641 2641 HOH HOH M . GA 11 HOH 642 2642 2642 HOH HOH M . GA 11 HOH 643 2643 2643 HOH HOH M . GA 11 HOH 644 2644 2644 HOH HOH M . GA 11 HOH 645 2645 2645 HOH HOH M . GA 11 HOH 646 2646 2646 HOH HOH M . GA 11 HOH 647 2647 2647 HOH HOH M . GA 11 HOH 648 2648 2648 HOH HOH M . GA 11 HOH 649 2649 2649 HOH HOH M . GA 11 HOH 650 2650 2650 HOH HOH M . GA 11 HOH 651 2651 2651 HOH HOH M . GA 11 HOH 652 2652 2652 HOH HOH M . GA 11 HOH 653 2653 2653 HOH HOH M . GA 11 HOH 654 2654 2654 HOH HOH M . GA 11 HOH 655 2655 2655 HOH HOH M . GA 11 HOH 656 2656 2656 HOH HOH M . GA 11 HOH 657 2657 2657 HOH HOH M . GA 11 HOH 658 2658 2658 HOH HOH M . GA 11 HOH 659 2659 2659 HOH HOH M . GA 11 HOH 660 2660 2660 HOH HOH M . GA 11 HOH 661 2661 2661 HOH HOH M . GA 11 HOH 662 2662 2662 HOH HOH M . GA 11 HOH 663 2663 2663 HOH HOH M . GA 11 HOH 664 2664 2664 HOH HOH M . GA 11 HOH 665 2665 2665 HOH HOH M . GA 11 HOH 666 2666 2666 HOH HOH M . GA 11 HOH 667 2667 2667 HOH HOH M . GA 11 HOH 668 2668 2668 HOH HOH M . GA 11 HOH 669 2669 2669 HOH HOH M . GA 11 HOH 670 2670 2670 HOH HOH M . GA 11 HOH 671 2671 2671 HOH HOH M . GA 11 HOH 672 2672 2672 HOH HOH M . GA 11 HOH 673 2673 2673 HOH HOH M . GA 11 HOH 674 2674 2674 HOH HOH M . GA 11 HOH 675 2675 2675 HOH HOH M . GA 11 HOH 676 2676 2676 HOH HOH M . GA 11 HOH 677 2677 2677 HOH HOH M . GA 11 HOH 678 2678 2678 HOH HOH M . GA 11 HOH 679 2679 2679 HOH HOH M . GA 11 HOH 680 2680 2680 HOH HOH M . GA 11 HOH 681 2681 2681 HOH HOH M . GA 11 HOH 682 2682 2682 HOH HOH M . GA 11 HOH 683 2683 2683 HOH HOH M . GA 11 HOH 684 2684 2684 HOH HOH M . GA 11 HOH 685 2685 2685 HOH HOH M . GA 11 HOH 686 2686 2686 HOH HOH M . GA 11 HOH 687 2687 2687 HOH HOH M . GA 11 HOH 688 2688 2688 HOH HOH M . GA 11 HOH 689 2689 2689 HOH HOH M . GA 11 HOH 690 2690 2690 HOH HOH M . GA 11 HOH 691 2691 2691 HOH HOH M . GA 11 HOH 692 2692 2692 HOH HOH M . GA 11 HOH 693 2693 2693 HOH HOH M . GA 11 HOH 694 2694 2694 HOH HOH M . GA 11 HOH 695 2695 2695 HOH HOH M . GA 11 HOH 696 2696 2696 HOH HOH M . GA 11 HOH 697 2697 2697 HOH HOH M . GA 11 HOH 698 2698 2698 HOH HOH M . GA 11 HOH 699 2699 2699 HOH HOH M . GA 11 HOH 700 2700 2700 HOH HOH M . GA 11 HOH 701 2701 2701 HOH HOH M . GA 11 HOH 702 2702 2702 HOH HOH M . GA 11 HOH 703 2703 2703 HOH HOH M . GA 11 HOH 704 2704 2704 HOH HOH M . GA 11 HOH 705 2705 2705 HOH HOH M . GA 11 HOH 706 2706 2706 HOH HOH M . GA 11 HOH 707 2707 2707 HOH HOH M . GA 11 HOH 708 2708 2708 HOH HOH M . GA 11 HOH 709 2709 2709 HOH HOH M . GA 11 HOH 710 2710 2710 HOH HOH M . GA 11 HOH 711 2711 2711 HOH HOH M . GA 11 HOH 712 2712 2712 HOH HOH M . GA 11 HOH 713 2713 2713 HOH HOH M . GA 11 HOH 714 2714 2714 HOH HOH M . GA 11 HOH 715 2715 2715 HOH HOH M . GA 11 HOH 716 2716 2716 HOH HOH M . GA 11 HOH 717 2717 2717 HOH HOH M . GA 11 HOH 718 2718 2718 HOH HOH M . GA 11 HOH 719 2719 2719 HOH HOH M . GA 11 HOH 720 2720 2720 HOH HOH M . GA 11 HOH 721 2721 2721 HOH HOH M . GA 11 HOH 722 2722 2722 HOH HOH M . GA 11 HOH 723 2723 2723 HOH HOH M . GA 11 HOH 724 2724 2724 HOH HOH M . GA 11 HOH 725 2725 2725 HOH HOH M . GA 11 HOH 726 2726 2726 HOH HOH M . GA 11 HOH 727 2727 2727 HOH HOH M . GA 11 HOH 728 2728 2728 HOH HOH M . GA 11 HOH 729 2729 2729 HOH HOH M . GA 11 HOH 730 2730 2730 HOH HOH M . GA 11 HOH 731 2731 2731 HOH HOH M . GA 11 HOH 732 2732 2732 HOH HOH M . GA 11 HOH 733 2733 2733 HOH HOH M . GA 11 HOH 734 2734 2734 HOH HOH M . GA 11 HOH 735 2735 2735 HOH HOH M . GA 11 HOH 736 2736 2736 HOH HOH M . GA 11 HOH 737 2737 2737 HOH HOH M . GA 11 HOH 738 2738 2738 HOH HOH M . GA 11 HOH 739 2739 2739 HOH HOH M . GA 11 HOH 740 2740 2740 HOH HOH M . GA 11 HOH 741 2741 2741 HOH HOH M . GA 11 HOH 742 2742 2742 HOH HOH M . GA 11 HOH 743 2743 2743 HOH HOH M . GA 11 HOH 744 2744 2744 HOH HOH M . GA 11 HOH 745 2745 2745 HOH HOH M . GA 11 HOH 746 2746 2746 HOH HOH M . GA 11 HOH 747 2747 2747 HOH HOH M . GA 11 HOH 748 2748 2748 HOH HOH M . GA 11 HOH 749 2749 2749 HOH HOH M . GA 11 HOH 750 2750 2750 HOH HOH M . GA 11 HOH 751 2751 2751 HOH HOH M . GA 11 HOH 752 2752 2752 HOH HOH M . GA 11 HOH 753 2753 2753 HOH HOH M . GA 11 HOH 754 2754 2754 HOH HOH M . GA 11 HOH 755 2755 2755 HOH HOH M . GA 11 HOH 756 2756 2756 HOH HOH M . GA 11 HOH 757 2757 2757 HOH HOH M . GA 11 HOH 758 2758 2758 HOH HOH M . GA 11 HOH 759 2759 2759 HOH HOH M . GA 11 HOH 760 2760 2760 HOH HOH M . GA 11 HOH 761 2761 2761 HOH HOH M . GA 11 HOH 762 2762 2762 HOH HOH M . GA 11 HOH 763 2763 2763 HOH HOH M . GA 11 HOH 764 2764 2764 HOH HOH M . # loop_ _pdbx_struct_mod_residue.id _pdbx_struct_mod_residue.label_asym_id _pdbx_struct_mod_residue.label_comp_id _pdbx_struct_mod_residue.label_seq_id _pdbx_struct_mod_residue.auth_asym_id _pdbx_struct_mod_residue.auth_comp_id _pdbx_struct_mod_residue.auth_seq_id _pdbx_struct_mod_residue.PDB_ins_code _pdbx_struct_mod_residue.parent_comp_id _pdbx_struct_mod_residue.details 1 A ASN 21 M ASN 21 ? ASN 'GLYCOSYLATION SITE' 2 A ASN 90 M ASN 90 ? ASN 'GLYCOSYLATION SITE' 3 A ASN 218 M ASN 218 ? ASN 'GLYCOSYLATION SITE' 4 A ASN 244 M ASN 244 ? ASN 'GLYCOSYLATION SITE' 5 A ASN 265 M ASN 265 ? ASN 'GLYCOSYLATION SITE' 6 A ASN 292 M ASN 292 ? ASN 'GLYCOSYLATION SITE' 7 A ASN 346 M ASN 346 ? ASN 'GLYCOSYLATION SITE' 8 A ASN 361 M ASN 361 ? ASN 'GLYCOSYLATION SITE' 9 A ASN 482 M ASN 482 ? ASN 'GLYCOSYLATION SITE' # _pdbx_struct_assembly.id 1 _pdbx_struct_assembly.details author_and_software_defined_assembly _pdbx_struct_assembly.method_details PQS _pdbx_struct_assembly.oligomeric_details monomeric _pdbx_struct_assembly.oligomeric_count 1 # _pdbx_struct_assembly_gen.assembly_id 1 _pdbx_struct_assembly_gen.oper_expression 1 _pdbx_struct_assembly_gen.asym_id_list A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R,S,T,U,V,W,X,Y,Z,AA,BA,CA,DA,EA,FA,GA # _pdbx_struct_oper_list.id 1 _pdbx_struct_oper_list.type 'identity operation' _pdbx_struct_oper_list.name 1_555 _pdbx_struct_oper_list.symmetry_operation x,y,z _pdbx_struct_oper_list.matrix[1][1] 1.0000000000 _pdbx_struct_oper_list.matrix[1][2] 0.0000000000 _pdbx_struct_oper_list.matrix[1][3] 0.0000000000 _pdbx_struct_oper_list.vector[1] 0.0000000000 _pdbx_struct_oper_list.matrix[2][1] 0.0000000000 _pdbx_struct_oper_list.matrix[2][2] 1.0000000000 _pdbx_struct_oper_list.matrix[2][3] 0.0000000000 _pdbx_struct_oper_list.vector[2] 0.0000000000 _pdbx_struct_oper_list.matrix[3][1] 0.0000000000 _pdbx_struct_oper_list.matrix[3][2] 0.0000000000 _pdbx_struct_oper_list.matrix[3][3] 1.0000000000 _pdbx_struct_oper_list.vector[3] 0.0000000000 # loop_ _pdbx_struct_special_symmetry.id _pdbx_struct_special_symmetry.PDB_model_num _pdbx_struct_special_symmetry.auth_asym_id _pdbx_struct_special_symmetry.auth_comp_id _pdbx_struct_special_symmetry.auth_seq_id _pdbx_struct_special_symmetry.PDB_ins_code _pdbx_struct_special_symmetry.label_asym_id _pdbx_struct_special_symmetry.label_comp_id _pdbx_struct_special_symmetry.label_seq_id 1 1 M ZN 1502 ? Z ZN . 2 1 M HOH 2026 ? GA HOH . 3 1 M HOH 2265 ? GA HOH . 4 1 M HOH 2292 ? GA HOH . # loop_ _pdbx_struct_conn_angle.id _pdbx_struct_conn_angle.ptnr1_label_atom_id _pdbx_struct_conn_angle.ptnr1_label_alt_id _pdbx_struct_conn_angle.ptnr1_label_asym_id _pdbx_struct_conn_angle.ptnr1_label_comp_id _pdbx_struct_conn_angle.ptnr1_label_seq_id _pdbx_struct_conn_angle.ptnr1_auth_atom_id _pdbx_struct_conn_angle.ptnr1_auth_asym_id _pdbx_struct_conn_angle.ptnr1_auth_comp_id _pdbx_struct_conn_angle.ptnr1_auth_seq_id _pdbx_struct_conn_angle.ptnr1_PDB_ins_code _pdbx_struct_conn_angle.ptnr1_symmetry _pdbx_struct_conn_angle.ptnr2_label_atom_id _pdbx_struct_conn_angle.ptnr2_label_alt_id _pdbx_struct_conn_angle.ptnr2_label_asym_id _pdbx_struct_conn_angle.ptnr2_label_comp_id _pdbx_struct_conn_angle.ptnr2_label_seq_id _pdbx_struct_conn_angle.ptnr2_auth_atom_id _pdbx_struct_conn_angle.ptnr2_auth_asym_id _pdbx_struct_conn_angle.ptnr2_auth_comp_id _pdbx_struct_conn_angle.ptnr2_auth_seq_id _pdbx_struct_conn_angle.ptnr2_PDB_ins_code _pdbx_struct_conn_angle.ptnr2_symmetry _pdbx_struct_conn_angle.ptnr3_label_atom_id _pdbx_struct_conn_angle.ptnr3_label_alt_id _pdbx_struct_conn_angle.ptnr3_label_asym_id _pdbx_struct_conn_angle.ptnr3_label_comp_id _pdbx_struct_conn_angle.ptnr3_label_seq_id _pdbx_struct_conn_angle.ptnr3_auth_atom_id _pdbx_struct_conn_angle.ptnr3_auth_asym_id _pdbx_struct_conn_angle.ptnr3_auth_comp_id _pdbx_struct_conn_angle.ptnr3_auth_seq_id _pdbx_struct_conn_angle.ptnr3_PDB_ins_code _pdbx_struct_conn_angle.ptnr3_symmetry _pdbx_struct_conn_angle.value _pdbx_struct_conn_angle.value_esd 1 OD2 ? A ASP 70 ? M ASP 70 ? 3_656 ZN ? Z ZN . ? M ZN 1502 ? 1_555 OD2 ? A ASP 70 ? M ASP 70 ? 1_555 91.1 ? 2 OD2 ? A ASP 70 ? M ASP 70 ? 3_656 ZN ? Z ZN . ? M ZN 1502 ? 1_555 NE2 ? A HIS 56 ? M HIS 56 ? 3_656 117.0 ? 3 OD2 ? A ASP 70 ? M ASP 70 ? 1_555 ZN ? Z ZN . ? M ZN 1502 ? 1_555 NE2 ? A HIS 56 ? M HIS 56 ? 3_656 109.6 ? 4 OD2 ? A ASP 70 ? M ASP 70 ? 3_656 ZN ? Z ZN . ? M ZN 1502 ? 1_555 NE2 ? A HIS 56 ? M HIS 56 ? 1_555 106.3 ? 5 OD2 ? A ASP 70 ? M ASP 70 ? 1_555 ZN ? Z ZN . ? M ZN 1502 ? 1_555 NE2 ? A HIS 56 ? M HIS 56 ? 1_555 117.4 ? 6 NE2 ? A HIS 56 ? M HIS 56 ? 3_656 ZN ? Z ZN . ? M ZN 1502 ? 1_555 NE2 ? A HIS 56 ? M HIS 56 ? 1_555 113.7 ? # loop_ _pdbx_audit_revision_history.ordinal _pdbx_audit_revision_history.data_content_type _pdbx_audit_revision_history.major_revision _pdbx_audit_revision_history.minor_revision _pdbx_audit_revision_history.revision_date 1 'Structure model' 1 0 2005-05-19 2 'Structure model' 1 1 2011-05-08 3 'Structure model' 1 2 2011-07-13 # _pdbx_audit_revision_details.ordinal 1 _pdbx_audit_revision_details.revision_ordinal 1 _pdbx_audit_revision_details.data_content_type 'Structure model' _pdbx_audit_revision_details.provider repository _pdbx_audit_revision_details.type 'Initial release' _pdbx_audit_revision_details.description ? # loop_ _pdbx_audit_revision_group.ordinal _pdbx_audit_revision_group.revision_ordinal _pdbx_audit_revision_group.data_content_type _pdbx_audit_revision_group.group 1 2 'Structure model' 'Version format compliance' 2 3 'Structure model' 'Version format compliance' # loop_ _software.name _software.classification _software.version _software.citation_id _software.pdbx_ordinal CNS refinement 1.0 ? 1 MOSFLM 'data reduction' . ? 2 SCALA 'data scaling' . ? 3 # _pdbx_database_remark.id 700 _pdbx_database_remark.text ; SHEET THE SHEET STRUCTURE OF THIS MOLECULE IS BIFURCATED. IN ORDER TO REPRESENT THIS FEATURE IN THE SHEET RECORDS BELOW, TWO SHEETS ARE DEFINED. ; # _pdbx_entry_details.entry_id 1W9B _pdbx_entry_details.compound_details ? _pdbx_entry_details.source_details ? _pdbx_entry_details.nonpolymer_details ? _pdbx_entry_details.sequence_details ;OUR SEQUENCE IS AN X-RAY SEQUENCE BASED ON THE ASSIGNMENT OF THE RESIDUES BY THEIR ELECTRON DENSITY. SOME AMBIGUITIES MAY EXIST. FURTHERMORE A DIFFERENT ISOFORM OF THE ENZYME MAY BE PRESENT IN THE CRYSTAL. THE SEQUENCE WAS ORIGINALLY IDENTIFIED DURING THE DETERMINATION OF THE STRUCTURE IN PDB ENTRY 1E4M. ; # _pdbx_validate_close_contact.id 1 _pdbx_validate_close_contact.PDB_model_num 1 _pdbx_validate_close_contact.auth_atom_id_1 C7 _pdbx_validate_close_contact.auth_asym_id_1 M _pdbx_validate_close_contact.auth_comp_id_1 CGT _pdbx_validate_close_contact.auth_seq_id_1 999 _pdbx_validate_close_contact.PDB_ins_code_1 ? _pdbx_validate_close_contact.label_alt_id_1 ? _pdbx_validate_close_contact.auth_atom_id_2 O _pdbx_validate_close_contact.auth_asym_id_2 M _pdbx_validate_close_contact.auth_comp_id_2 HOH _pdbx_validate_close_contact.auth_seq_id_2 2739 _pdbx_validate_close_contact.PDB_ins_code_2 ? _pdbx_validate_close_contact.label_alt_id_2 ? _pdbx_validate_close_contact.dist 1.87 # loop_ _pdbx_validate_torsion.id _pdbx_validate_torsion.PDB_model_num _pdbx_validate_torsion.auth_comp_id _pdbx_validate_torsion.auth_asym_id _pdbx_validate_torsion.auth_seq_id _pdbx_validate_torsion.PDB_ins_code _pdbx_validate_torsion.label_alt_id _pdbx_validate_torsion.phi _pdbx_validate_torsion.psi 1 1 THR M 72 ? ? 40.75 -140.00 2 1 HIS M 141 ? ? -107.17 55.77 3 1 TRP M 142 ? ? 74.33 -14.95 4 1 TYR M 152 ? ? -144.24 22.21 5 1 THR M 184 ? ? -79.09 -74.57 6 1 GLN M 187 ? ? 37.29 81.64 7 1 TYR M 330 ? ? -130.09 -48.34 8 1 ASN M 410 ? ? -169.58 116.92 9 1 ALA M 458 ? ? 70.57 100.74 10 1 ASN M 466 ? ? 76.45 -18.42 11 1 ASN M 482 ? ? -159.77 85.11 # loop_ _pdbx_distant_solvent_atoms.id _pdbx_distant_solvent_atoms.PDB_model_num _pdbx_distant_solvent_atoms.auth_atom_id _pdbx_distant_solvent_atoms.label_alt_id _pdbx_distant_solvent_atoms.auth_asym_id _pdbx_distant_solvent_atoms.auth_comp_id _pdbx_distant_solvent_atoms.auth_seq_id _pdbx_distant_solvent_atoms.PDB_ins_code _pdbx_distant_solvent_atoms.neighbor_macromolecule_distance _pdbx_distant_solvent_atoms.neighbor_ligand_distance 1 1 O ? M HOH 2048 ? 6.45 . 2 1 O ? M HOH 2151 ? 6.13 . # loop_ _pdbx_unobs_or_zero_occ_residues.id _pdbx_unobs_or_zero_occ_residues.PDB_model_num _pdbx_unobs_or_zero_occ_residues.polymer_flag _pdbx_unobs_or_zero_occ_residues.occupancy_flag _pdbx_unobs_or_zero_occ_residues.auth_asym_id _pdbx_unobs_or_zero_occ_residues.auth_comp_id _pdbx_unobs_or_zero_occ_residues.auth_seq_id _pdbx_unobs_or_zero_occ_residues.PDB_ins_code _pdbx_unobs_or_zero_occ_residues.label_asym_id _pdbx_unobs_or_zero_occ_residues.label_comp_id _pdbx_unobs_or_zero_occ_residues.label_seq_id 1 1 Y 1 M ASP 1 ? A ASP 1 2 1 Y 1 M GLU 2 ? A GLU 2 # loop_ _pdbx_entity_nonpoly.entity_id _pdbx_entity_nonpoly.name _pdbx_entity_nonpoly.comp_id 2 N-ACETYL-D-GLUCOSAMINE NAG 3 ALPHA-L-FUCOSE FUC 4 BETA-D-MANNOSE BMA 5 BETA-D-XYLOPYRANOSE XYP 6 ALPHA-D-MANNOSE MAN 7 CARBA-GLUCOTROPAEOLIN CGT 8 GLYCEROL GOL 9 'ZINC ION' ZN 10 'SULFATE ION' SO4 11 water HOH #