data_1MZ5 # _entry.id 1MZ5 # _audit_conform.dict_name mmcif_pdbx.dic _audit_conform.dict_version 5.281 _audit_conform.dict_location http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic # loop_ _database_2.database_id _database_2.database_code PDB 1MZ5 RCSB RCSB017319 WWPDB D_1000017319 # loop_ _pdbx_database_related.db_name _pdbx_database_related.db_id _pdbx_database_related.details _pdbx_database_related.content_type PDB 1MZ6 'Trypanosoma rangeli sialidase in complex with inhibitor DANA' unspecified PDB 1MR5 'Orthorhombic form of Trypanosoma cruzi trans-sialidase' unspecified PDB 1MS0 ;Monoclinic form of Trypanosoma cruzi trans-sialidase, in complex with 3-deoxy-2,3-dehydro-N-acetylneuraminic acid (DANA)and lactose ; unspecified PDB 1MS1 ;Monoclinic form of Trypanosoma cruzi trans-sialidase, in complex with 3-deoxy-2,3-dehydro-N-acetylneuraminic acid (DANA) ; unspecified PDB 1MS3 'Monoclinic form of Trypanosoma cruzi trans-sialidase' unspecified PDB 1MS4 'Triclinic form of Trypanosoma cruzi trans-sialidase' unspecified PDB 1MS5 ;Triclinic form of Trypanosoma cruzi trans-sialidase, soaked with N-acetylneuraminyl-a-2,3-thio-galactoside (NA-S-Gal) ; unspecified PDB 1MS8 ;Triclinic form of Trypanosoma cruzi trans-sialidase, in complex with 3-deoxy-2,3-dehydro-N-acetylneuraminic acid (DANA) ; unspecified PDB 1MS9 'Triclinic form of Trypanosoma cruzi trans-sialidase, in complex with lactose' unspecified # _pdbx_database_status.status_code REL _pdbx_database_status.entry_id 1MZ5 _pdbx_database_status.recvd_initial_deposition_date 2002-10-05 _pdbx_database_status.deposit_site RCSB _pdbx_database_status.process_site RCSB _pdbx_database_status.SG_entry . _pdbx_database_status.pdb_format_compatible Y _pdbx_database_status.status_code_mr ? _pdbx_database_status.status_code_sf ? _pdbx_database_status.status_code_cs ? # loop_ _audit_author.name _audit_author.pdbx_ordinal 'Buschiazzo, A.' 1 'Tavares, G.A.' 2 'Campetella, O.' 3 'Spinelli, S.' 4 'Cremona, M.L.' 5 'Paris, G.' 6 'Amaya, M.F.' 7 'Frasch, A.C.C.' 8 'Alzari, P.M.' 9 # _citation.id primary _citation.title 'Structural basis of sialyltransferase activity in trypanosomal sialidases' _citation.journal_abbrev 'Embo J.' _citation.journal_volume 19 _citation.page_first 16 _citation.page_last 24 _citation.year 2000 _citation.journal_id_ASTM EMJODG _citation.country UK _citation.journal_id_ISSN 0261-4189 _citation.journal_id_CSD 0897 _citation.book_publisher ? _citation.pdbx_database_id_PubMed 10619840 _citation.pdbx_database_id_DOI 10.1093/emboj/19.1.16 # loop_ _citation_author.citation_id _citation_author.name _citation_author.ordinal primary 'Buschiazzo, A.' 1 primary 'Tavares, G.A.' 2 primary 'Campetella, O.' 3 primary 'Spinelli, S.' 4 primary 'Cremona, M.L.' 5 primary 'Paris, G.' 6 primary 'Amaya, M.F.' 7 primary 'Frasch, A.C.C.' 8 primary 'Alzari, P.M.' 9 # _cell.entry_id 1MZ5 _cell.length_a 76.150 _cell.length_b 93.410 _cell.length_c 105.480 _cell.angle_alpha 90.00 _cell.angle_beta 90.00 _cell.angle_gamma 90.00 _cell.Z_PDB 4 _cell.pdbx_unique_axis ? # _symmetry.entry_id 1MZ5 _symmetry.space_group_name_H-M 'P 21 21 21' _symmetry.pdbx_full_space_group_name_H-M ? _symmetry.cell_setting ? _symmetry.Int_Tables_number 19 # loop_ _entity.id _entity.type _entity.src_method _entity.pdbx_description _entity.formula_weight _entity.pdbx_number_of_molecules _entity.pdbx_ec _entity.pdbx_mutation _entity.pdbx_fragment _entity.details 1 polymer nat sialidase 69705.445 1 3.2.1.18 ? 'mature sialidase' ? 2 non-polymer man N-ACETYL-D-GLUCOSAMINE 221.208 5 ? ? ? ? 3 water nat water 18.015 365 ? ? ? ? # _entity_poly.entity_id 1 _entity_poly.type 'polypeptide(L)' _entity_poly.nstd_linkage no _entity_poly.nstd_monomer no _entity_poly.pdbx_seq_one_letter_code ;LAPGSSRVELFKRKNSTVPFEESNGTIRERVVHSFRIPTIVNVDGVMVATADARYETSFDNSFIETAVKYSVDDGATWNT QIAIKNSRASSVSRVMDATVIVKGNKLYILVGSFNKTRNSWTQHRDGSDWEPLLVVGEVTKSAANGKTTATISWGKPVSL KPLFPAEFDGILTKEFVGGVGAAIVGSNGNLVYPVQIADMGGRVFTKIMYSEDDGNTWKFAEGRSKFGCSEPAVLEWEGK LIINNRVDGNRRLVYESSDMGKTWVEALGTLSHVWTNSPTSNQQDCQSSFVAVTIEGKRVMLFTHPLNLKGRWMRDRLHL WMTDNQRIFDVGQISIGDENSGYSSVLYKDDKLYSLHEINTNDVYSLVFVRFIGELQLMKSVVRTWKEEDNHLASICTPV VPATPPSKGGCGAAVPTAGLVGFLSHSANGSVWEDVYRCVDANVANAERVPNGLKFNGVGGGAVWPVARQGQTRRYQFAN YRFTLVATVTIDELPKGTSPLLGAGLEGPGDAKLLGLSYDKNRQWRPLYGAAPASPTGSWELHKKYHVVLTMADRQGSVY VDGQPLAGSGNTVVRGATLPDISHFYIGGPRSKGAPTDSRVTVTNIVLYNRRLNSSEIRTLFLSQDMIGTDGGAGTAA ; _entity_poly.pdbx_seq_one_letter_code_can ;LAPGSSRVELFKRKNSTVPFEESNGTIRERVVHSFRIPTIVNVDGVMVATADARYETSFDNSFIETAVKYSVDDGATWNT QIAIKNSRASSVSRVMDATVIVKGNKLYILVGSFNKTRNSWTQHRDGSDWEPLLVVGEVTKSAANGKTTATISWGKPVSL KPLFPAEFDGILTKEFVGGVGAAIVGSNGNLVYPVQIADMGGRVFTKIMYSEDDGNTWKFAEGRSKFGCSEPAVLEWEGK LIINNRVDGNRRLVYESSDMGKTWVEALGTLSHVWTNSPTSNQQDCQSSFVAVTIEGKRVMLFTHPLNLKGRWMRDRLHL WMTDNQRIFDVGQISIGDENSGYSSVLYKDDKLYSLHEINTNDVYSLVFVRFIGELQLMKSVVRTWKEEDNHLASICTPV VPATPPSKGGCGAAVPTAGLVGFLSHSANGSVWEDVYRCVDANVANAERVPNGLKFNGVGGGAVWPVARQGQTRRYQFAN YRFTLVATVTIDELPKGTSPLLGAGLEGPGDAKLLGLSYDKNRQWRPLYGAAPASPTGSWELHKKYHVVLTMADRQGSVY VDGQPLAGSGNTVVRGATLPDISHFYIGGPRSKGAPTDSRVTVTNIVLYNRRLNSSEIRTLFLSQDMIGTDGGAGTAA ; _entity_poly.pdbx_strand_id A _entity_poly.pdbx_target_identifier ? # loop_ _entity_poly_seq.entity_id _entity_poly_seq.num _entity_poly_seq.mon_id _entity_poly_seq.hetero 1 1 LEU n 1 2 ALA n 1 3 PRO n 1 4 GLY n 1 5 SER n 1 6 SER n 1 7 ARG n 1 8 VAL n 1 9 GLU n 1 10 LEU n 1 11 PHE n 1 12 LYS n 1 13 ARG n 1 14 LYS n 1 15 ASN n 1 16 SER n 1 17 THR n 1 18 VAL n 1 19 PRO n 1 20 PHE n 1 21 GLU n 1 22 GLU n 1 23 SER n 1 24 ASN n 1 25 GLY n 1 26 THR n 1 27 ILE n 1 28 ARG n 1 29 GLU n 1 30 ARG n 1 31 VAL n 1 32 VAL n 1 33 HIS n 1 34 SER n 1 35 PHE n 1 36 ARG n 1 37 ILE n 1 38 PRO n 1 39 THR n 1 40 ILE n 1 41 VAL n 1 42 ASN n 1 43 VAL n 1 44 ASP n 1 45 GLY n 1 46 VAL n 1 47 MET n 1 48 VAL n 1 49 ALA n 1 50 THR n 1 51 ALA n 1 52 ASP n 1 53 ALA n 1 54 ARG n 1 55 TYR n 1 56 GLU n 1 57 THR n 1 58 SER n 1 59 PHE n 1 60 ASP n 1 61 ASN n 1 62 SER n 1 63 PHE n 1 64 ILE n 1 65 GLU n 1 66 THR n 1 67 ALA n 1 68 VAL n 1 69 LYS n 1 70 TYR n 1 71 SER n 1 72 VAL n 1 73 ASP n 1 74 ASP n 1 75 GLY n 1 76 ALA n 1 77 THR n 1 78 TRP n 1 79 ASN n 1 80 THR n 1 81 GLN n 1 82 ILE n 1 83 ALA n 1 84 ILE n 1 85 LYS n 1 86 ASN n 1 87 SER n 1 88 ARG n 1 89 ALA n 1 90 SER n 1 91 SER n 1 92 VAL n 1 93 SER n 1 94 ARG n 1 95 VAL n 1 96 MET n 1 97 ASP n 1 98 ALA n 1 99 THR n 1 100 VAL n 1 101 ILE n 1 102 VAL n 1 103 LYS n 1 104 GLY n 1 105 ASN n 1 106 LYS n 1 107 LEU n 1 108 TYR n 1 109 ILE n 1 110 LEU n 1 111 VAL n 1 112 GLY n 1 113 SER n 1 114 PHE n 1 115 ASN n 1 116 LYS n 1 117 THR n 1 118 ARG n 1 119 ASN n 1 120 SER n 1 121 TRP n 1 122 THR n 1 123 GLN n 1 124 HIS n 1 125 ARG n 1 126 ASP n 1 127 GLY n 1 128 SER n 1 129 ASP n 1 130 TRP n 1 131 GLU n 1 132 PRO n 1 133 LEU n 1 134 LEU n 1 135 VAL n 1 136 VAL n 1 137 GLY n 1 138 GLU n 1 139 VAL n 1 140 THR n 1 141 LYS n 1 142 SER n 1 143 ALA n 1 144 ALA n 1 145 ASN n 1 146 GLY n 1 147 LYS n 1 148 THR n 1 149 THR n 1 150 ALA n 1 151 THR n 1 152 ILE n 1 153 SER n 1 154 TRP n 1 155 GLY n 1 156 LYS n 1 157 PRO n 1 158 VAL n 1 159 SER n 1 160 LEU n 1 161 LYS n 1 162 PRO n 1 163 LEU n 1 164 PHE n 1 165 PRO n 1 166 ALA n 1 167 GLU n 1 168 PHE n 1 169 ASP n 1 170 GLY n 1 171 ILE n 1 172 LEU n 1 173 THR n 1 174 LYS n 1 175 GLU n 1 176 PHE n 1 177 VAL n 1 178 GLY n 1 179 GLY n 1 180 VAL n 1 181 GLY n 1 182 ALA n 1 183 ALA n 1 184 ILE n 1 185 VAL n 1 186 GLY n 1 187 SER n 1 188 ASN n 1 189 GLY n 1 190 ASN n 1 191 LEU n 1 192 VAL n 1 193 TYR n 1 194 PRO n 1 195 VAL n 1 196 GLN n 1 197 ILE n 1 198 ALA n 1 199 ASP n 1 200 MET n 1 201 GLY n 1 202 GLY n 1 203 ARG n 1 204 VAL n 1 205 PHE n 1 206 THR n 1 207 LYS n 1 208 ILE n 1 209 MET n 1 210 TYR n 1 211 SER n 1 212 GLU n 1 213 ASP n 1 214 ASP n 1 215 GLY n 1 216 ASN n 1 217 THR n 1 218 TRP n 1 219 LYS n 1 220 PHE n 1 221 ALA n 1 222 GLU n 1 223 GLY n 1 224 ARG n 1 225 SER n 1 226 LYS n 1 227 PHE n 1 228 GLY n 1 229 CYS n 1 230 SER n 1 231 GLU n 1 232 PRO n 1 233 ALA n 1 234 VAL n 1 235 LEU n 1 236 GLU n 1 237 TRP n 1 238 GLU n 1 239 GLY n 1 240 LYS n 1 241 LEU n 1 242 ILE n 1 243 ILE n 1 244 ASN n 1 245 ASN n 1 246 ARG n 1 247 VAL n 1 248 ASP n 1 249 GLY n 1 250 ASN n 1 251 ARG n 1 252 ARG n 1 253 LEU n 1 254 VAL n 1 255 TYR n 1 256 GLU n 1 257 SER n 1 258 SER n 1 259 ASP n 1 260 MET n 1 261 GLY n 1 262 LYS n 1 263 THR n 1 264 TRP n 1 265 VAL n 1 266 GLU n 1 267 ALA n 1 268 LEU n 1 269 GLY n 1 270 THR n 1 271 LEU n 1 272 SER n 1 273 HIS n 1 274 VAL n 1 275 TRP n 1 276 THR n 1 277 ASN n 1 278 SER n 1 279 PRO n 1 280 THR n 1 281 SER n 1 282 ASN n 1 283 GLN n 1 284 GLN n 1 285 ASP n 1 286 CYS n 1 287 GLN n 1 288 SER n 1 289 SER n 1 290 PHE n 1 291 VAL n 1 292 ALA n 1 293 VAL n 1 294 THR n 1 295 ILE n 1 296 GLU n 1 297 GLY n 1 298 LYS n 1 299 ARG n 1 300 VAL n 1 301 MET n 1 302 LEU n 1 303 PHE n 1 304 THR n 1 305 HIS n 1 306 PRO n 1 307 LEU n 1 308 ASN n 1 309 LEU n 1 310 LYS n 1 311 GLY n 1 312 ARG n 1 313 TRP n 1 314 MET n 1 315 ARG n 1 316 ASP n 1 317 ARG n 1 318 LEU n 1 319 HIS n 1 320 LEU n 1 321 TRP n 1 322 MET n 1 323 THR n 1 324 ASP n 1 325 ASN n 1 326 GLN n 1 327 ARG n 1 328 ILE n 1 329 PHE n 1 330 ASP n 1 331 VAL n 1 332 GLY n 1 333 GLN n 1 334 ILE n 1 335 SER n 1 336 ILE n 1 337 GLY n 1 338 ASP n 1 339 GLU n 1 340 ASN n 1 341 SER n 1 342 GLY n 1 343 TYR n 1 344 SER n 1 345 SER n 1 346 VAL n 1 347 LEU n 1 348 TYR n 1 349 LYS n 1 350 ASP n 1 351 ASP n 1 352 LYS n 1 353 LEU n 1 354 TYR n 1 355 SER n 1 356 LEU n 1 357 HIS n 1 358 GLU n 1 359 ILE n 1 360 ASN n 1 361 THR n 1 362 ASN n 1 363 ASP n 1 364 VAL n 1 365 TYR n 1 366 SER n 1 367 LEU n 1 368 VAL n 1 369 PHE n 1 370 VAL n 1 371 ARG n 1 372 PHE n 1 373 ILE n 1 374 GLY n 1 375 GLU n 1 376 LEU n 1 377 GLN n 1 378 LEU n 1 379 MET n 1 380 LYS n 1 381 SER n 1 382 VAL n 1 383 VAL n 1 384 ARG n 1 385 THR n 1 386 TRP n 1 387 LYS n 1 388 GLU n 1 389 GLU n 1 390 ASP n 1 391 ASN n 1 392 HIS n 1 393 LEU n 1 394 ALA n 1 395 SER n 1 396 ILE n 1 397 CYS n 1 398 THR n 1 399 PRO n 1 400 VAL n 1 401 VAL n 1 402 PRO n 1 403 ALA n 1 404 THR n 1 405 PRO n 1 406 PRO n 1 407 SER n 1 408 LYS n 1 409 GLY n 1 410 GLY n 1 411 CYS n 1 412 GLY n 1 413 ALA n 1 414 ALA n 1 415 VAL n 1 416 PRO n 1 417 THR n 1 418 ALA n 1 419 GLY n 1 420 LEU n 1 421 VAL n 1 422 GLY n 1 423 PHE n 1 424 LEU n 1 425 SER n 1 426 HIS n 1 427 SER n 1 428 ALA n 1 429 ASN n 1 430 GLY n 1 431 SER n 1 432 VAL n 1 433 TRP n 1 434 GLU n 1 435 ASP n 1 436 VAL n 1 437 TYR n 1 438 ARG n 1 439 CYS n 1 440 VAL n 1 441 ASP n 1 442 ALA n 1 443 ASN n 1 444 VAL n 1 445 ALA n 1 446 ASN n 1 447 ALA n 1 448 GLU n 1 449 ARG n 1 450 VAL n 1 451 PRO n 1 452 ASN n 1 453 GLY n 1 454 LEU n 1 455 LYS n 1 456 PHE n 1 457 ASN n 1 458 GLY n 1 459 VAL n 1 460 GLY n 1 461 GLY n 1 462 GLY n 1 463 ALA n 1 464 VAL n 1 465 TRP n 1 466 PRO n 1 467 VAL n 1 468 ALA n 1 469 ARG n 1 470 GLN n 1 471 GLY n 1 472 GLN n 1 473 THR n 1 474 ARG n 1 475 ARG n 1 476 TYR n 1 477 GLN n 1 478 PHE n 1 479 ALA n 1 480 ASN n 1 481 TYR n 1 482 ARG n 1 483 PHE n 1 484 THR n 1 485 LEU n 1 486 VAL n 1 487 ALA n 1 488 THR n 1 489 VAL n 1 490 THR n 1 491 ILE n 1 492 ASP n 1 493 GLU n 1 494 LEU n 1 495 PRO n 1 496 LYS n 1 497 GLY n 1 498 THR n 1 499 SER n 1 500 PRO n 1 501 LEU n 1 502 LEU n 1 503 GLY n 1 504 ALA n 1 505 GLY n 1 506 LEU n 1 507 GLU n 1 508 GLY n 1 509 PRO n 1 510 GLY n 1 511 ASP n 1 512 ALA n 1 513 LYS n 1 514 LEU n 1 515 LEU n 1 516 GLY n 1 517 LEU n 1 518 SER n 1 519 TYR n 1 520 ASP n 1 521 LYS n 1 522 ASN n 1 523 ARG n 1 524 GLN n 1 525 TRP n 1 526 ARG n 1 527 PRO n 1 528 LEU n 1 529 TYR n 1 530 GLY n 1 531 ALA n 1 532 ALA n 1 533 PRO n 1 534 ALA n 1 535 SER n 1 536 PRO n 1 537 THR n 1 538 GLY n 1 539 SER n 1 540 TRP n 1 541 GLU n 1 542 LEU n 1 543 HIS n 1 544 LYS n 1 545 LYS n 1 546 TYR n 1 547 HIS n 1 548 VAL n 1 549 VAL n 1 550 LEU n 1 551 THR n 1 552 MET n 1 553 ALA n 1 554 ASP n 1 555 ARG n 1 556 GLN n 1 557 GLY n 1 558 SER n 1 559 VAL n 1 560 TYR n 1 561 VAL n 1 562 ASP n 1 563 GLY n 1 564 GLN n 1 565 PRO n 1 566 LEU n 1 567 ALA n 1 568 GLY n 1 569 SER n 1 570 GLY n 1 571 ASN n 1 572 THR n 1 573 VAL n 1 574 VAL n 1 575 ARG n 1 576 GLY n 1 577 ALA n 1 578 THR n 1 579 LEU n 1 580 PRO n 1 581 ASP n 1 582 ILE n 1 583 SER n 1 584 HIS n 1 585 PHE n 1 586 TYR n 1 587 ILE n 1 588 GLY n 1 589 GLY n 1 590 PRO n 1 591 ARG n 1 592 SER n 1 593 LYS n 1 594 GLY n 1 595 ALA n 1 596 PRO n 1 597 THR n 1 598 ASP n 1 599 SER n 1 600 ARG n 1 601 VAL n 1 602 THR n 1 603 VAL n 1 604 THR n 1 605 ASN n 1 606 ILE n 1 607 VAL n 1 608 LEU n 1 609 TYR n 1 610 ASN n 1 611 ARG n 1 612 ARG n 1 613 LEU n 1 614 ASN n 1 615 SER n 1 616 SER n 1 617 GLU n 1 618 ILE n 1 619 ARG n 1 620 THR n 1 621 LEU n 1 622 PHE n 1 623 LEU n 1 624 SER n 1 625 GLN n 1 626 ASP n 1 627 MET n 1 628 ILE n 1 629 GLY n 1 630 THR n 1 631 ASP n 1 632 GLY n 1 633 GLY n 1 634 ALA n 1 635 GLY n 1 636 THR n 1 637 ALA n 1 638 ALA n # _entity_src_nat.entity_id 1 _entity_src_nat.pdbx_src_id 1 _entity_src_nat.pdbx_alt_source_flag sample _entity_src_nat.pdbx_beg_seq_num ? _entity_src_nat.pdbx_end_seq_num ? _entity_src_nat.common_name ? _entity_src_nat.pdbx_organism_scientific 'Trypanosoma rangeli' _entity_src_nat.pdbx_ncbi_taxonomy_id 5698 _entity_src_nat.genus Trypanosoma _entity_src_nat.species ? _entity_src_nat.strain ? _entity_src_nat.tissue ? _entity_src_nat.tissue_fraction ? _entity_src_nat.pdbx_secretion ? _entity_src_nat.pdbx_fragment ? _entity_src_nat.pdbx_variant ? _entity_src_nat.pdbx_cell_line ? _entity_src_nat.pdbx_atcc ? _entity_src_nat.pdbx_cellular_location ? _entity_src_nat.pdbx_organ ? _entity_src_nat.pdbx_organelle ? _entity_src_nat.pdbx_cell ? _entity_src_nat.pdbx_plasmid_name ? _entity_src_nat.pdbx_plasmid_details ? _entity_src_nat.details ? # _struct_ref.id 1 _struct_ref.db_name UNP _struct_ref.db_code O44049_TRYRA _struct_ref.entity_id 1 _struct_ref.pdbx_seq_one_letter_code ;LAPGSSRVELFKRKNSTVPFEESNGTIRERVVHSFRIPTIVNVDGVMVATADARYETSFDNSFIETAVKYSVDDGATWNT QIAIKNSRASSVSRVMDATVIVKGNKLYILVGSFNKTRNSWTQHRDGSDWEPLLVVGEVTKSAANGKTTATISWGKPVSL KPLFPAEFDGILTKEFIGGVGAAIVGSNGNLVYPVQIADMGGRVFTKIMYSEDDGNTWKFAEGRSKFGCSEPAVLEWEGK LIINNRVDGNRRLVYESSDMGKTWVEALGTLSHVWTNSPTSNQQDCQSSFVAVTIEGKRVMLFTHPLNLKGRWMRDRLHL WMTDNQRIFDVGQISIGDENSGYSSVLYKDDKLYSLHEINTNDVYSLVFVRFIGELQLMKSVVRTWKEEDNHLASICTPV VPATPPSKGGCGAAVPTAGLVGFLSHSANGSVWEDVYRCVDANVANAERVPNGLKFNGVGGGAVWPVARQGQTRRYQFAN YRFTLVATVTIDELPKGTSPLLGAGLEGPGDAKLLGLSYDKNRQWRPLYGAAPASPTGSWELHKKYHVVLTMADRQGSVY VDGQPLAGSGNTVVRGATLPDISHFYIGGPRSKGAPTDSRVTVTNIVLYNRRLNSSEIRTLFLSQDMIGTDGGAGTAA ; _struct_ref.pdbx_align_begin 23 _struct_ref.pdbx_db_accession O44049 _struct_ref.pdbx_db_isoform ? # _struct_ref_seq.align_id 1 _struct_ref_seq.ref_id 1 _struct_ref_seq.pdbx_PDB_id_code 1MZ5 _struct_ref_seq.pdbx_strand_id A _struct_ref_seq.seq_align_beg 1 _struct_ref_seq.pdbx_seq_align_beg_ins_code ? _struct_ref_seq.seq_align_end 638 _struct_ref_seq.pdbx_seq_align_end_ins_code ? _struct_ref_seq.pdbx_db_accession O44049 _struct_ref_seq.db_align_beg 23 _struct_ref_seq.pdbx_db_align_beg_ins_code ? _struct_ref_seq.db_align_end 660 _struct_ref_seq.pdbx_db_align_end_ins_code ? _struct_ref_seq.pdbx_auth_seq_align_beg 1 _struct_ref_seq.pdbx_auth_seq_align_end 638 # _struct_ref_seq_dif.align_id 1 _struct_ref_seq_dif.pdbx_pdb_id_code 1MZ5 _struct_ref_seq_dif.mon_id VAL _struct_ref_seq_dif.pdbx_pdb_strand_id A _struct_ref_seq_dif.seq_num 177 _struct_ref_seq_dif.pdbx_pdb_ins_code ? _struct_ref_seq_dif.pdbx_seq_db_name UNP _struct_ref_seq_dif.pdbx_seq_db_accession_code O44049 _struct_ref_seq_dif.db_mon_id ILE _struct_ref_seq_dif.pdbx_seq_db_seq_num 199 _struct_ref_seq_dif.details CONFLICT _struct_ref_seq_dif.pdbx_auth_seq_num 177 _struct_ref_seq_dif.pdbx_ordinal 1 # loop_ _chem_comp.id _chem_comp.type _chem_comp.mon_nstd_flag _chem_comp.name _chem_comp.pdbx_synonyms _chem_comp.formula _chem_comp.formula_weight ALA 'L-peptide linking' y ALANINE ? 'C3 H7 N O2' 89.093 ARG 'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1' 175.209 ASN 'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3' 132.118 ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4' 133.103 CYS 'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S' 121.158 GLN 'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3' 146.144 GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4' 147.129 GLY 'peptide linking' y GLYCINE ? 'C2 H5 N O2' 75.067 HIS 'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1' 156.162 HOH non-polymer . WATER ? 'H2 O' 18.015 ILE 'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2' 131.173 LEU 'L-peptide linking' y LEUCINE ? 'C6 H13 N O2' 131.173 LYS 'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1' 147.195 MET 'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S' 149.211 NAG D-saccharide . N-ACETYL-D-GLUCOSAMINE ? 'C8 H15 N O6' 221.208 PHE 'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2' 165.189 PRO 'L-peptide linking' y PROLINE ? 'C5 H9 N O2' 115.130 SER 'L-peptide linking' y SERINE ? 'C3 H7 N O3' 105.093 THR 'L-peptide linking' y THREONINE ? 'C4 H9 N O3' 119.119 TRP 'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2' 204.225 TYR 'L-peptide linking' y TYROSINE ? 'C9 H11 N O3' 181.189 VAL 'L-peptide linking' y VALINE ? 'C5 H11 N O2' 117.146 # _exptl.entry_id 1MZ5 _exptl.method 'X-RAY DIFFRACTION' _exptl.crystals_number 1 # _exptl_crystal.id 1 _exptl_crystal.density_meas ? _exptl_crystal.density_percent_sol 54.27 _exptl_crystal.density_Matthews 2.69 _exptl_crystal.description ? # _exptl_crystal_grow.crystal_id 1 _exptl_crystal_grow.method 'VAPOR DIFFUSION, HANGING DROP' _exptl_crystal_grow.temp 293 _exptl_crystal_grow.temp_details ? _exptl_crystal_grow.pH 6.5 _exptl_crystal_grow.pdbx_details 'PEG-8000, ammonium sulfate, morpholinoethanesulfonate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K' _exptl_crystal_grow.pdbx_pH_range ? # _diffrn.id 1 _diffrn.ambient_temp 100 _diffrn.ambient_temp_details ? _diffrn.crystal_id 1 # _diffrn_detector.diffrn_id 1 _diffrn_detector.detector 'IMAGE PLATE' _diffrn_detector.type MARRESEARCH _diffrn_detector.pdbx_collection_date 1998-12-07 _diffrn_detector.details ? # _diffrn_radiation.diffrn_id 1 _diffrn_radiation.wavelength_id 1 _diffrn_radiation.monochromator ? _diffrn_radiation.pdbx_monochromatic_or_laue_m_l M _diffrn_radiation.pdbx_diffrn_protocol 'SINGLE WAVELENGTH' _diffrn_radiation.pdbx_scattering_type x-ray # _diffrn_radiation_wavelength.id 1 _diffrn_radiation_wavelength.wavelength 0.95 _diffrn_radiation_wavelength.wt 1.0 # _diffrn_source.diffrn_id 1 _diffrn_source.source SYNCHROTRON _diffrn_source.type 'EMBL/DESY, HAMBURG BEAMLINE BW7B' _diffrn_source.pdbx_synchrotron_site 'EMBL/DESY, Hamburg' _diffrn_source.pdbx_synchrotron_beamline BW7B _diffrn_source.pdbx_wavelength ? _diffrn_source.pdbx_wavelength_list 0.95 # _reflns.entry_id 1MZ5 _reflns.observed_criterion_sigma_F 0 _reflns.observed_criterion_sigma_I 0 _reflns.d_resolution_high 2.2 _reflns.d_resolution_low 20 _reflns.number_all 38612 _reflns.number_obs 38612 _reflns.percent_possible_obs 99.3 _reflns.pdbx_Rmerge_I_obs ? _reflns.pdbx_Rsym_value 0.126 _reflns.pdbx_netI_over_sigmaI ? _reflns.B_iso_Wilson_estimate ? _reflns.pdbx_redundancy 5.4 _reflns.R_free_details ? _reflns.limit_h_max ? _reflns.limit_h_min ? _reflns.limit_k_max ? _reflns.limit_k_min ? _reflns.limit_l_max ? _reflns.limit_l_min ? _reflns.observed_criterion_F_max ? _reflns.observed_criterion_F_min ? _reflns.pdbx_ordinal 1 _reflns.pdbx_diffrn_id 1 # _reflns_shell.d_res_high 2.2 _reflns_shell.d_res_low 2.24 _reflns_shell.percent_possible_all 97.7 _reflns_shell.Rmerge_I_obs ? _reflns_shell.pdbx_Rsym_value 0.354 _reflns_shell.meanI_over_sigI_obs ? _reflns_shell.pdbx_redundancy ? _reflns_shell.percent_possible_obs ? _reflns_shell.number_unique_all ? _reflns_shell.pdbx_ordinal 1 _reflns_shell.pdbx_diffrn_id 1 # _refine.entry_id 1MZ5 _refine.ls_number_reflns_obs 36590 _refine.ls_number_reflns_all 36590 _refine.pdbx_ls_sigma_I 0 _refine.pdbx_ls_sigma_F 0 _refine.pdbx_data_cutoff_high_absF ? _refine.pdbx_data_cutoff_low_absF ? _refine.ls_d_res_low 15.00 _refine.ls_d_res_high 2.20 _refine.ls_percent_reflns_obs 99.46 _refine.ls_R_factor_obs 0.18327 _refine.ls_R_factor_all 0.18327 _refine.ls_R_factor_R_work 0.18042 _refine.ls_R_factor_R_free 0.23747 _refine.ls_R_factor_R_free_error ? _refine.ls_R_factor_R_free_error_details ? _refine.ls_percent_reflns_R_free 5.0 _refine.ls_number_reflns_R_free 1938 _refine.ls_number_parameters ? _refine.ls_number_restraints ? _refine.occupancy_min ? _refine.occupancy_max ? _refine.correlation_coeff_Fo_to_Fc 0.938 _refine.correlation_coeff_Fo_to_Fc_free 0.894 _refine.B_iso_mean 17.573 _refine.aniso_B[1][1] 0.59 _refine.aniso_B[2][2] 0.18 _refine.aniso_B[3][3] -0.77 _refine.aniso_B[1][2] 0.00 _refine.aniso_B[1][3] 0.00 _refine.aniso_B[2][3] 0.00 _refine.solvent_model_details 'BABINET MODEL WITH MASK' _refine.solvent_model_param_ksol ? _refine.solvent_model_param_bsol ? _refine.pdbx_solvent_vdw_probe_radii 1.40 _refine.pdbx_solvent_ion_probe_radii 0.80 _refine.pdbx_solvent_shrinkage_radii 0.80 _refine.pdbx_ls_cross_valid_method THROUGHOUT _refine.details ? _refine.pdbx_starting_model ? _refine.pdbx_method_to_determine_struct 'MIR + Molecular Replacement' _refine.pdbx_isotropic_thermal_model ? _refine.pdbx_stereochemistry_target_values 'MAXIMUM LIKELIHOOD' _refine.pdbx_stereochem_target_val_spec_case ? _refine.pdbx_R_Free_selection_details RANDOM _refine.pdbx_overall_ESU_R_Free ? _refine.overall_SU_B ? _refine.ls_redundancy_reflns_obs ? _refine.B_iso_min ? _refine.B_iso_max ? _refine.overall_SU_R_Cruickshank_DPI ? _refine.overall_SU_R_free ? _refine.overall_SU_ML ? _refine.pdbx_overall_ESU_R ? _refine.pdbx_data_cutoff_high_rms_absF ? _refine.pdbx_refine_id 'X-RAY DIFFRACTION' _refine.pdbx_diffrn_id 1 _refine.pdbx_TLS_residual_ADP_flag ? _refine.pdbx_overall_phase_error ? _refine.pdbx_overall_SU_R_free_Cruickshank_DPI ? _refine.pdbx_overall_SU_R_Blow_DPI ? _refine.pdbx_overall_SU_R_free_Blow_DPI ? # _refine_hist.pdbx_refine_id 'X-RAY DIFFRACTION' _refine_hist.cycle_id LAST _refine_hist.pdbx_number_atoms_protein 4768 _refine_hist.pdbx_number_atoms_nucleic_acid 0 _refine_hist.pdbx_number_atoms_ligand 70 _refine_hist.number_atoms_solvent 365 _refine_hist.number_atoms_total 5203 _refine_hist.d_res_high 2.20 _refine_hist.d_res_low 15.00 # loop_ _refine_ls_restr.type _refine_ls_restr.dev_ideal _refine_ls_restr.dev_ideal_target _refine_ls_restr.weight _refine_ls_restr.number _refine_ls_restr.pdbx_refine_id _refine_ls_restr.pdbx_restraint_function r_bond_refined_d 0.017 0.021 ? 4951 'X-RAY DIFFRACTION' ? r_angle_refined_deg 1.825 1.950 ? 6737 'X-RAY DIFFRACTION' ? r_dihedral_angle_1_deg 5.232 3.000 ? 619 'X-RAY DIFFRACTION' ? r_dihedral_angle_3_deg 18.261 15.000 ? 828 'X-RAY DIFFRACTION' ? r_chiral_restr 0.130 0.200 ? 764 'X-RAY DIFFRACTION' ? r_gen_planes_refined 0.007 0.020 ? 3735 'X-RAY DIFFRACTION' ? r_nbd_refined 0.244 0.300 ? 2331 'X-RAY DIFFRACTION' ? r_xyhbond_nbd_refined 0.146 0.500 ? 625 'X-RAY DIFFRACTION' ? r_symmetry_vdw_refined 0.248 0.300 ? 20 'X-RAY DIFFRACTION' ? r_symmetry_hbond_refined 0.251 0.500 ? 9 'X-RAY DIFFRACTION' ? r_mcbond_it 0.841 1.500 ? 3075 'X-RAY DIFFRACTION' ? r_mcangle_it 1.525 2.000 ? 4950 'X-RAY DIFFRACTION' ? r_scbond_it 2.490 3.000 ? 1876 'X-RAY DIFFRACTION' ? r_scangle_it 3.951 4.500 ? 1787 'X-RAY DIFFRACTION' ? # _refine_ls_shell.pdbx_total_number_of_bins_used 20 _refine_ls_shell.d_res_high 2.200 _refine_ls_shell.d_res_low 2.256 _refine_ls_shell.number_reflns_R_work 2586 _refine_ls_shell.R_factor_R_work 0.198 _refine_ls_shell.percent_reflns_obs ? _refine_ls_shell.R_factor_R_free 0.269 _refine_ls_shell.R_factor_R_free_error ? _refine_ls_shell.percent_reflns_R_free ? _refine_ls_shell.number_reflns_R_free 143 _refine_ls_shell.number_reflns_obs ? _refine_ls_shell.redundancy_reflns_obs ? _refine_ls_shell.number_reflns_all ? _refine_ls_shell.pdbx_refine_id 'X-RAY DIFFRACTION' _refine_ls_shell.R_factor_all ? # _struct.entry_id 1MZ5 _struct.title 'Trypanosoma rangeli sialidase' _struct.pdbx_descriptor 'sialidase (3.2.1.18)' _struct.pdbx_model_details ? _struct.pdbx_CASP_flag ? _struct.pdbx_model_type_details ? # _struct_keywords.entry_id 1MZ5 _struct_keywords.pdbx_keywords HYDROLASE _struct_keywords.text 'inibitor complex, trypanosomal sialidase, sialyltransferase, hydrolase' # loop_ _struct_asym.id _struct_asym.pdbx_blank_PDB_chainid_flag _struct_asym.pdbx_modified _struct_asym.entity_id _struct_asym.details A N N 1 ? B N N 2 ? C N N 2 ? D N N 2 ? E N N 2 ? F N N 2 ? G N N 3 ? # _struct_biol.id 1 # loop_ _struct_conf.conf_type_id _struct_conf.id _struct_conf.pdbx_PDB_helix_id _struct_conf.beg_label_comp_id _struct_conf.beg_label_asym_id _struct_conf.beg_label_seq_id _struct_conf.pdbx_beg_PDB_ins_code _struct_conf.end_label_comp_id _struct_conf.end_label_asym_id _struct_conf.end_label_seq_id _struct_conf.pdbx_end_PDB_ins_code _struct_conf.beg_auth_comp_id _struct_conf.beg_auth_asym_id _struct_conf.beg_auth_seq_id _struct_conf.end_auth_comp_id _struct_conf.end_auth_asym_id _struct_conf.end_auth_seq_id _struct_conf.pdbx_PDB_helix_class _struct_conf.details _struct_conf.pdbx_PDB_helix_length HELX_P HELX_P1 1 SER A 120 ? HIS A 124 ? SER A 120 HIS A 124 5 ? 5 HELX_P HELX_P2 2 LYS A 161 ? PHE A 164 ? LYS A 161 PHE A 164 5 ? 4 HELX_P HELX_P3 3 PHE A 372 ? ILE A 396 ? PHE A 372 ILE A 396 1 ? 25 HELX_P HELX_P4 4 ALA A 468 ? GLY A 471 ? ALA A 468 GLY A 471 5 ? 4 HELX_P HELX_P5 5 TYR A 476 ? TYR A 481 ? TYR A 476 TYR A 481 5 ? 6 HELX_P HELX_P6 6 ASN A 614 ? GLN A 625 ? ASN A 614 GLN A 625 1 ? 12 # _struct_conf_type.id HELX_P _struct_conf_type.criteria ? _struct_conf_type.reference ? # loop_ _struct_conn.id _struct_conn.conn_type_id _struct_conn.pdbx_leaving_atom_flag _struct_conn.pdbx_PDB_id _struct_conn.ptnr1_label_asym_id _struct_conn.ptnr1_label_comp_id _struct_conn.ptnr1_label_seq_id _struct_conn.ptnr1_label_atom_id _struct_conn.pdbx_ptnr1_label_alt_id _struct_conn.pdbx_ptnr1_PDB_ins_code _struct_conn.pdbx_ptnr1_standard_comp_id _struct_conn.ptnr1_symmetry _struct_conn.ptnr2_label_asym_id _struct_conn.ptnr2_label_comp_id _struct_conn.ptnr2_label_seq_id _struct_conn.ptnr2_label_atom_id _struct_conn.pdbx_ptnr2_label_alt_id _struct_conn.pdbx_ptnr2_PDB_ins_code _struct_conn.ptnr1_auth_asym_id _struct_conn.ptnr1_auth_comp_id _struct_conn.ptnr1_auth_seq_id _struct_conn.ptnr2_auth_asym_id _struct_conn.ptnr2_auth_comp_id _struct_conn.ptnr2_auth_seq_id _struct_conn.ptnr2_symmetry _struct_conn.pdbx_ptnr3_label_atom_id _struct_conn.pdbx_ptnr3_label_seq_id _struct_conn.pdbx_ptnr3_label_comp_id _struct_conn.pdbx_ptnr3_label_asym_id _struct_conn.pdbx_ptnr3_label_alt_id _struct_conn.pdbx_ptnr3_PDB_ins_code _struct_conn.details _struct_conn.pdbx_dist_value _struct_conn.pdbx_value_order disulf1 disulf ? ? A CYS 397 SG ? ? ? 1_555 A CYS 411 SG ? ? A CYS 397 A CYS 411 1_555 ? ? ? ? ? ? ? 2.030 ? covale1 covale ? ? A ASN 15 ND2 ? ? ? 1_555 B NAG . C1 ? ? A ASN 15 A NAG 651 1_555 ? ? ? ? ? ? ? 1.455 ? covale2 covale ? ? A ASN 24 ND2 ? ? ? 1_555 C NAG . C1 ? ? A ASN 24 A NAG 652 1_555 ? ? ? ? ? ? ? 1.447 ? covale3 covale ? ? A ASN 115 ND2 ? ? ? 1_555 D NAG . C1 ? ? A ASN 115 A NAG 653 1_555 ? ? ? ? ? ? ? 1.445 ? covale4 covale ? ? A ASN 429 ND2 ? ? ? 1_555 E NAG . C1 ? ? A ASN 429 A NAG 654 1_555 ? ? ? ? ? ? ? 1.429 ? covale5 covale ? ? A ASN 614 ND2 ? ? ? 1_555 F NAG . C1 ? ? A ASN 614 A NAG 655 1_555 ? ? ? ? ? ? ? 1.437 ? # loop_ _struct_conn_type.id _struct_conn_type.criteria _struct_conn_type.reference disulf ? ? covale ? ? # loop_ _struct_sheet.id _struct_sheet.type _struct_sheet.number_strands _struct_sheet.details A ? 4 ? B ? 2 ? C ? 4 ? D ? 7 ? E ? 7 ? F ? 4 ? G ? 4 ? H ? 19 ? # loop_ _struct_sheet_order.sheet_id _struct_sheet_order.range_id_1 _struct_sheet_order.range_id_2 _struct_sheet_order.offset _struct_sheet_order.sense A 1 2 ? anti-parallel A 2 3 ? anti-parallel A 3 4 ? anti-parallel B 1 2 ? anti-parallel C 1 2 ? anti-parallel C 2 3 ? anti-parallel C 3 4 ? anti-parallel D 1 2 ? anti-parallel D 2 3 ? anti-parallel D 3 4 ? anti-parallel D 4 5 ? anti-parallel D 5 6 ? anti-parallel D 6 7 ? parallel E 1 2 ? anti-parallel E 2 3 ? anti-parallel E 3 4 ? anti-parallel E 4 5 ? anti-parallel E 5 6 ? anti-parallel E 6 7 ? anti-parallel F 1 2 ? anti-parallel F 2 3 ? anti-parallel F 3 4 ? anti-parallel G 1 2 ? anti-parallel G 2 3 ? anti-parallel G 3 4 ? anti-parallel H 1 2 ? anti-parallel H 2 3 ? anti-parallel H 3 4 ? anti-parallel H 4 5 ? anti-parallel H 5 6 ? anti-parallel H 6 7 ? anti-parallel H 7 8 ? anti-parallel H 8 9 ? anti-parallel H 9 10 ? anti-parallel H 10 11 ? anti-parallel H 11 12 ? anti-parallel H 12 13 ? anti-parallel H 13 14 ? anti-parallel H 14 15 ? anti-parallel H 15 16 ? anti-parallel H 16 17 ? anti-parallel H 17 18 ? anti-parallel H 18 19 ? anti-parallel # loop_ _struct_sheet_range.sheet_id _struct_sheet_range.id _struct_sheet_range.beg_label_comp_id _struct_sheet_range.beg_label_asym_id _struct_sheet_range.beg_label_seq_id _struct_sheet_range.pdbx_beg_PDB_ins_code _struct_sheet_range.end_label_comp_id _struct_sheet_range.end_label_asym_id _struct_sheet_range.end_label_seq_id _struct_sheet_range.pdbx_end_PDB_ins_code _struct_sheet_range.beg_auth_comp_id _struct_sheet_range.beg_auth_asym_id _struct_sheet_range.beg_auth_seq_id _struct_sheet_range.end_auth_comp_id _struct_sheet_range.end_auth_asym_id _struct_sheet_range.end_auth_seq_id A 1 SER A 6 ? PHE A 11 ? SER A 6 PHE A 11 A 2 VAL A 364 ? ARG A 371 ? VAL A 364 ARG A 371 A 3 LYS A 352 ? THR A 361 ? LYS A 352 THR A 361 A 4 SER A 344 ? LYS A 349 ? SER A 344 LYS A 349 B 1 THR A 17 ? GLU A 21 ? THR A 17 GLU A 21 B 2 ILE A 27 ? VAL A 31 ? ILE A 27 VAL A 31 C 1 SER A 34 ? VAL A 43 ? SER A 34 VAL A 43 C 2 VAL A 46 ? ARG A 54 ? VAL A 46 ARG A 54 C 3 ILE A 64 ? SER A 71 ? ILE A 64 SER A 71 C 4 ASN A 79 ? ILE A 84 ? ASN A 79 ILE A 84 D 1 THR A 149 ? TRP A 154 ? THR A 149 TRP A 154 D 2 TRP A 130 ? SER A 142 ? TRP A 130 SER A 142 D 3 VAL A 158 ? SER A 159 ? VAL A 158 SER A 159 D 4 TRP A 130 ? SER A 142 ? TRP A 130 SER A 142 D 5 LYS A 106 ? PHE A 114 ? LYS A 106 PHE A 114 D 6 ARG A 94 ? LYS A 103 ? ARG A 94 LYS A 103 D 7 GLY A 181 ? ALA A 182 ? GLY A 181 ALA A 182 E 1 GLU A 167 ? PHE A 168 ? GLU A 167 PHE A 168 E 2 ILE A 171 ? GLY A 178 ? ILE A 171 GLY A 178 E 3 LEU A 191 ? ASP A 199 ? LEU A 191 ASP A 199 E 4 ILE A 184 ? VAL A 185 ? ILE A 184 VAL A 185 E 5 LEU A 191 ? ASP A 199 ? LEU A 191 ASP A 199 E 6 VAL A 204 ? SER A 211 ? VAL A 204 SER A 211 E 7 LYS A 219 ? PHE A 220 ? LYS A 219 PHE A 220 F 1 CYS A 229 ? TRP A 237 ? CYS A 229 TRP A 237 F 2 LYS A 240 ? VAL A 247 ? LYS A 240 VAL A 247 F 3 VAL A 254 ? SER A 257 ? VAL A 254 SER A 257 F 4 VAL A 265 ? GLU A 266 ? VAL A 265 GLU A 266 G 1 PHE A 290 ? ILE A 295 ? PHE A 290 ILE A 295 G 2 LYS A 298 ? PRO A 306 ? LYS A 298 PRO A 306 G 3 LEU A 318 ? THR A 323 ? LEU A 318 THR A 323 G 4 ILE A 328 ? GLN A 333 ? ILE A 328 GLN A 333 H 1 TRP A 525 ? TYR A 529 ? TRP A 525 TYR A 529 H 2 LYS A 513 ? ASP A 520 ? LYS A 513 ASP A 520 H 3 THR A 498 ? LEU A 506 ? THR A 498 LEU A 506 H 4 ILE A 582 ? GLY A 588 ? ILE A 582 GLY A 588 H 5 GLY A 462 ? PRO A 466 ? GLY A 462 PRO A 466 H 6 ALA A 442 ? ALA A 445 ? ALA A 442 ALA A 445 H 7 VAL A 432 ? ASP A 435 ? VAL A 432 ASP A 435 H 8 LEU A 420 ? ALA A 428 ? LEU A 420 ALA A 428 H 9 VAL A 601 ? TYR A 609 ? VAL A 601 TYR A 609 H 10 GLY A 453 ? PHE A 456 ? GLY A 453 PHE A 456 H 11 ALA A 447 ? VAL A 450 ? ALA A 447 VAL A 450 H 12 GLY A 453 ? PHE A 456 ? GLY A 453 PHE A 456 H 13 VAL A 601 ? TYR A 609 ? VAL A 601 TYR A 609 H 14 PHE A 483 ? ILE A 491 ? PHE A 483 ILE A 491 H 15 LYS A 545 ? ALA A 553 ? LYS A 545 ALA A 553 H 16 GLN A 556 ? VAL A 561 ? GLN A 556 VAL A 561 H 17 GLN A 564 ? PRO A 565 ? GLN A 564 PRO A 565 H 18 GLN A 556 ? VAL A 561 ? GLN A 556 VAL A 561 H 19 ASN A 571 ? THR A 572 ? ASN A 571 THR A 572 # loop_ _pdbx_struct_sheet_hbond.sheet_id _pdbx_struct_sheet_hbond.range_id_1 _pdbx_struct_sheet_hbond.range_id_2 _pdbx_struct_sheet_hbond.range_1_label_atom_id _pdbx_struct_sheet_hbond.range_1_label_comp_id _pdbx_struct_sheet_hbond.range_1_label_asym_id _pdbx_struct_sheet_hbond.range_1_label_seq_id _pdbx_struct_sheet_hbond.range_1_PDB_ins_code _pdbx_struct_sheet_hbond.range_1_auth_atom_id _pdbx_struct_sheet_hbond.range_1_auth_comp_id _pdbx_struct_sheet_hbond.range_1_auth_asym_id _pdbx_struct_sheet_hbond.range_1_auth_seq_id _pdbx_struct_sheet_hbond.range_2_label_atom_id _pdbx_struct_sheet_hbond.range_2_label_comp_id _pdbx_struct_sheet_hbond.range_2_label_asym_id _pdbx_struct_sheet_hbond.range_2_label_seq_id _pdbx_struct_sheet_hbond.range_2_PDB_ins_code _pdbx_struct_sheet_hbond.range_2_auth_atom_id _pdbx_struct_sheet_hbond.range_2_auth_comp_id _pdbx_struct_sheet_hbond.range_2_auth_asym_id _pdbx_struct_sheet_hbond.range_2_auth_seq_id A 1 2 O PHE A 11 ? O PHE A 11 N LEU A 367 ? N LEU A 367 A 2 3 N VAL A 370 ? N VAL A 370 O SER A 355 ? O SER A 355 A 3 4 N LEU A 356 ? N LEU A 356 O SER A 345 ? O SER A 345 B 1 2 O PHE A 20 ? O PHE A 20 N ARG A 28 ? N ARG A 28 C 1 2 O VAL A 43 ? O VAL A 43 N VAL A 46 ? N VAL A 46 C 2 3 N ALA A 53 ? N ALA A 53 O GLU A 65 ? O GLU A 65 C 3 4 O TYR A 70 ? O TYR A 70 N ASN A 79 ? N ASN A 79 D 1 2 O SER A 153 ? O SER A 153 N GLU A 138 ? N GLU A 138 D 2 3 N LEU A 134 ? N LEU A 134 O VAL A 158 ? O VAL A 158 D 3 4 O VAL A 158 ? O VAL A 158 N LEU A 134 ? N LEU A 134 D 4 5 N GLY A 137 ? N GLY A 137 O LEU A 107 ? O LEU A 107 D 5 6 N PHE A 114 ? N PHE A 114 O ARG A 94 ? O ARG A 94 D 6 7 N VAL A 100 ? N VAL A 100 O GLY A 181 ? O GLY A 181 E 1 2 O PHE A 168 ? O PHE A 168 N ILE A 171 ? N ILE A 171 E 2 3 O VAL A 177 ? O VAL A 177 N GLN A 196 ? N GLN A 196 E 3 4 N VAL A 192 ? N VAL A 192 O ILE A 184 ? O ILE A 184 E 4 5 O ILE A 184 ? O ILE A 184 N VAL A 192 ? N VAL A 192 E 5 6 N ILE A 197 ? N ILE A 197 O PHE A 205 ? O PHE A 205 E 6 7 N TYR A 210 ? N TYR A 210 O LYS A 219 ? O LYS A 219 F 1 2 N TRP A 237 ? N TRP A 237 O LYS A 240 ? O LYS A 240 F 2 3 N ILE A 243 ? N ILE A 243 O TYR A 255 ? O TYR A 255 F 3 4 N GLU A 256 ? N GLU A 256 O VAL A 265 ? O VAL A 265 G 1 2 N ILE A 295 ? N ILE A 295 O LYS A 298 ? O LYS A 298 G 2 3 O HIS A 305 ? O HIS A 305 N HIS A 319 ? N HIS A 319 G 3 4 O MET A 322 ? O MET A 322 N PHE A 329 ? N PHE A 329 H 1 2 N LEU A 528 ? N LEU A 528 O GLY A 516 ? O GLY A 516 H 2 3 O TYR A 519 ? O TYR A 519 N SER A 499 ? N SER A 499 H 3 4 O GLY A 505 ? O GLY A 505 N SER A 583 ? N SER A 583 H 4 5 O ILE A 587 ? O ILE A 587 N ALA A 463 ? N ALA A 463 H 5 6 O VAL A 464 ? O VAL A 464 N ASN A 443 ? N ASN A 443 H 6 7 O ALA A 442 ? O ALA A 442 N TRP A 433 ? N TRP A 433 H 7 8 O GLU A 434 ? O GLU A 434 N SER A 425 ? N SER A 425 H 8 9 N LEU A 424 ? N LEU A 424 O ILE A 606 ? O ILE A 606 H 9 10 N VAL A 603 ? N VAL A 603 O LEU A 454 ? O LEU A 454 H 10 11 N LYS A 455 ? N LYS A 455 O GLU A 448 ? O GLU A 448 H 11 12 N VAL A 450 ? N VAL A 450 O GLY A 453 ? O GLY A 453 H 12 13 N PHE A 456 ? N PHE A 456 O VAL A 601 ? O VAL A 601 H 13 14 N TYR A 609 ? N TYR A 609 O THR A 484 ? O THR A 484 H 14 15 O VAL A 489 ? O VAL A 489 N TYR A 546 ? N TYR A 546 H 15 16 O ALA A 553 ? O ALA A 553 N GLN A 556 ? N GLN A 556 H 16 17 N VAL A 561 ? N VAL A 561 O GLN A 564 ? O GLN A 564 H 17 18 O GLN A 564 ? O GLN A 564 N VAL A 561 ? N VAL A 561 H 18 19 N GLY A 557 ? N GLY A 557 O ASN A 571 ? O ASN A 571 # loop_ _struct_site.id _struct_site.pdbx_evidence_code _struct_site.pdbx_auth_asym_id _struct_site.pdbx_auth_comp_id _struct_site.pdbx_auth_seq_id _struct_site.pdbx_auth_ins_code _struct_site.pdbx_num_residues _struct_site.details AC1 Software ? ? ? ? 2 'BINDING SITE FOR RESIDUE NAG A 651' AC2 Software ? ? ? ? 2 'BINDING SITE FOR RESIDUE NAG A 652' AC3 Software ? ? ? ? 3 'BINDING SITE FOR RESIDUE NAG A 653' AC4 Software ? ? ? ? 4 'BINDING SITE FOR RESIDUE NAG A 654' AC5 Software ? ? ? ? 4 'BINDING SITE FOR RESIDUE NAG A 655' # loop_ _struct_site_gen.id _struct_site_gen.site_id _struct_site_gen.pdbx_num_res _struct_site_gen.label_comp_id _struct_site_gen.label_asym_id _struct_site_gen.label_seq_id _struct_site_gen.pdbx_auth_ins_code _struct_site_gen.auth_comp_id _struct_site_gen.auth_asym_id _struct_site_gen.auth_seq_id _struct_site_gen.label_atom_id _struct_site_gen.label_alt_id _struct_site_gen.symmetry _struct_site_gen.details 1 AC1 2 LYS A 12 ? LYS A 12 . ? 1_555 ? 2 AC1 2 ASN A 15 ? ASN A 15 . ? 1_555 ? 3 AC2 2 ASN A 24 ? ASN A 24 . ? 1_555 ? 4 AC2 2 THR A 26 ? THR A 26 . ? 1_555 ? 5 AC3 3 ASN A 115 ? ASN A 115 . ? 1_555 ? 6 AC3 3 SER A 128 ? SER A 128 . ? 1_555 ? 7 AC3 3 TRP A 130 ? TRP A 130 . ? 1_555 ? 8 AC4 4 ASN A 429 ? ASN A 429 . ? 1_555 ? 9 AC4 4 SER A 431 ? SER A 431 . ? 1_555 ? 10 AC4 4 VAL A 432 ? VAL A 432 . ? 1_555 ? 11 AC4 4 GLU A 434 ? GLU A 434 . ? 1_555 ? 12 AC5 4 ASN A 614 ? ASN A 614 . ? 1_555 ? 13 AC5 4 GLU A 617 ? GLU A 617 . ? 1_555 ? 14 AC5 4 HOH G . ? HOH A 907 . ? 1_555 ? 15 AC5 4 HOH G . ? HOH A 936 . ? 1_555 ? # _database_PDB_matrix.entry_id 1MZ5 _database_PDB_matrix.origx[1][1] 1.000000 _database_PDB_matrix.origx[1][2] 0.000000 _database_PDB_matrix.origx[1][3] 0.000000 _database_PDB_matrix.origx[2][1] 0.000000 _database_PDB_matrix.origx[2][2] 1.000000 _database_PDB_matrix.origx[2][3] 0.000000 _database_PDB_matrix.origx[3][1] 0.000000 _database_PDB_matrix.origx[3][2] 0.000000 _database_PDB_matrix.origx[3][3] 1.000000 _database_PDB_matrix.origx_vector[1] 0.00000 _database_PDB_matrix.origx_vector[2] 0.00000 _database_PDB_matrix.origx_vector[3] 0.00000 # _atom_sites.entry_id 1MZ5 _atom_sites.fract_transf_matrix[1][1] 0.013132 _atom_sites.fract_transf_matrix[1][2] 0.000000 _atom_sites.fract_transf_matrix[1][3] 0.000000 _atom_sites.fract_transf_matrix[2][1] 0.000000 _atom_sites.fract_transf_matrix[2][2] 0.010705 _atom_sites.fract_transf_matrix[2][3] 0.000000 _atom_sites.fract_transf_matrix[3][1] 0.000000 _atom_sites.fract_transf_matrix[3][2] 0.000000 _atom_sites.fract_transf_matrix[3][3] 0.009480 _atom_sites.fract_transf_vector[1] 0.00000 _atom_sites.fract_transf_vector[2] 0.00000 _atom_sites.fract_transf_vector[3] 0.00000 # loop_ _atom_type.symbol C N O S # loop_ _atom_site.group_PDB _atom_site.id _atom_site.type_symbol _atom_site.label_atom_id _atom_site.label_alt_id _atom_site.label_comp_id _atom_site.label_asym_id _atom_site.label_entity_id _atom_site.label_seq_id _atom_site.pdbx_PDB_ins_code _atom_site.Cartn_x _atom_site.Cartn_y _atom_site.Cartn_z _atom_site.occupancy _atom_site.B_iso_or_equiv _atom_site.pdbx_formal_charge _atom_site.auth_seq_id _atom_site.auth_comp_id _atom_site.auth_asym_id _atom_site.auth_atom_id _atom_site.pdbx_PDB_model_num ATOM 1 N N . LEU A 1 1 ? 48.711 1.967 9.340 1.00 11.93 ? 1 LEU A N 1 ATOM 2 C CA . LEU A 1 1 ? 48.787 3.358 8.804 1.00 11.52 ? 1 LEU A CA 1 ATOM 3 C C . LEU A 1 1 ? 50.241 3.583 8.411 1.00 10.87 ? 1 LEU A C 1 ATOM 4 O O . LEU A 1 1 ? 51.133 3.168 9.135 1.00 11.53 ? 1 LEU A O 1 ATOM 5 C CB . LEU A 1 1 ? 48.318 4.349 9.868 1.00 10.68 ? 1 LEU A CB 1 ATOM 6 C CG . LEU A 1 1 ? 48.260 5.822 9.444 1.00 11.25 ? 1 LEU A CG 1 ATOM 7 C CD1 . LEU A 1 1 ? 47.339 6.011 8.273 1.00 7.52 ? 1 LEU A CD1 1 ATOM 8 C CD2 . LEU A 1 1 ? 47.837 6.734 10.621 1.00 12.65 ? 1 LEU A CD2 1 ATOM 9 N N . ALA A 1 2 ? 50.481 4.213 7.277 1.00 9.91 ? 2 ALA A N 1 ATOM 10 C CA . ALA A 1 2 ? 51.842 4.364 6.748 1.00 10.85 ? 2 ALA A CA 1 ATOM 11 C C . ALA A 1 2 ? 52.691 5.356 7.556 1.00 11.49 ? 2 ALA A C 1 ATOM 12 O O . ALA A 1 2 ? 52.173 6.328 8.121 1.00 12.07 ? 2 ALA A O 1 ATOM 13 C CB . ALA A 1 2 ? 51.782 4.859 5.272 1.00 9.85 ? 2 ALA A CB 1 ATOM 14 N N . PRO A 1 3 ? 53.989 5.151 7.583 1.00 12.55 ? 3 PRO A N 1 ATOM 15 C CA . PRO A 1 3 ? 54.855 6.141 8.238 1.00 13.40 ? 3 PRO A CA 1 ATOM 16 C C . PRO A 1 3 ? 54.640 7.499 7.570 1.00 14.50 ? 3 PRO A C 1 ATOM 17 O O . PRO A 1 3 ? 54.523 7.584 6.328 1.00 14.44 ? 3 PRO A O 1 ATOM 18 C CB . PRO A 1 3 ? 56.258 5.619 7.966 1.00 13.53 ? 3 PRO A CB 1 ATOM 19 C CG . PRO A 1 3 ? 56.034 4.136 7.839 1.00 14.27 ? 3 PRO A CG 1 ATOM 20 C CD . PRO A 1 3 ? 54.728 3.982 7.058 1.00 11.48 ? 3 PRO A CD 1 ATOM 21 N N . GLY A 1 4 ? 54.537 8.547 8.379 1.00 13.97 ? 4 GLY A N 1 ATOM 22 C CA . GLY A 1 4 ? 54.326 9.876 7.832 1.00 14.00 ? 4 GLY A CA 1 ATOM 23 C C . GLY A 1 4 ? 52.845 10.230 7.839 1.00 14.76 ? 4 GLY A C 1 ATOM 24 O O . GLY A 1 4 ? 52.496 11.371 7.800 1.00 14.63 ? 4 GLY A O 1 ATOM 25 N N . SER A 1 5 ? 51.957 9.249 7.922 1.00 14.25 ? 5 SER A N 1 ATOM 26 C CA . SER A 1 5 ? 50.537 9.588 7.933 1.00 14.24 ? 5 SER A CA 1 ATOM 27 C C . SER A 1 5 ? 50.086 9.806 9.367 1.00 13.60 ? 5 SER A C 1 ATOM 28 O O . SER A 1 5 ? 50.833 9.557 10.295 1.00 13.62 ? 5 SER A O 1 ATOM 29 C CB . SER A 1 5 ? 49.701 8.478 7.260 1.00 14.08 ? 5 SER A CB 1 ATOM 30 O OG . SER A 1 5 ? 50.116 8.284 5.922 1.00 12.43 ? 5 SER A OG 1 ATOM 31 N N . SER A 1 6 ? 48.865 10.277 9.540 1.00 13.63 ? 6 SER A N 1 ATOM 32 C CA . SER A 1 6 ? 48.339 10.528 10.875 1.00 14.40 ? 6 SER A CA 1 ATOM 33 C C . SER A 1 6 ? 46.828 10.707 10.827 1.00 14.68 ? 6 SER A C 1 ATOM 34 O O . SER A 1 6 ? 46.237 10.846 9.737 1.00 13.96 ? 6 SER A O 1 ATOM 35 C CB . SER A 1 6 ? 49.003 11.775 11.522 1.00 14.38 ? 6 SER A CB 1 ATOM 36 O OG . SER A 1 6 ? 48.576 12.961 10.870 1.00 15.84 ? 6 SER A OG 1 ATOM 37 N N . ARG A 1 7 ? 46.202 10.710 12.009 1.00 15.58 ? 7 ARG A N 1 ATOM 38 C CA . ARG A 1 7 ? 44.755 10.821 12.109 1.00 16.82 ? 7 ARG A CA 1 ATOM 39 C C . ARG A 1 7 ? 44.318 11.460 13.443 1.00 17.79 ? 7 ARG A C 1 ATOM 40 O O . ARG A 1 7 ? 45.122 11.585 14.369 1.00 18.11 ? 7 ARG A O 1 ATOM 41 C CB . ARG A 1 7 ? 44.142 9.425 11.981 1.00 17.67 ? 7 ARG A CB 1 ATOM 42 C CG . ARG A 1 7 ? 44.267 8.514 13.270 1.00 17.84 ? 7 ARG A CG 1 ATOM 43 C CD . ARG A 1 7 ? 43.883 7.038 13.053 1.00 19.03 ? 7 ARG A CD 1 ATOM 44 N NE . ARG A 1 7 ? 43.593 6.371 14.328 1.00 17.24 ? 7 ARG A NE 1 ATOM 45 C CZ . ARG A 1 7 ? 43.259 5.107 14.483 1.00 14.51 ? 7 ARG A CZ 1 ATOM 46 N NH1 . ARG A 1 7 ? 43.166 4.268 13.429 1.00 7.71 ? 7 ARG A NH1 1 ATOM 47 N NH2 . ARG A 1 7 ? 42.999 4.696 15.717 1.00 7.61 ? 7 ARG A NH2 1 ATOM 48 N N . VAL A 1 8 ? 43.047 11.861 13.510 1.00 17.46 ? 8 VAL A N 1 ATOM 49 C CA . VAL A 1 8 ? 42.435 12.405 14.697 1.00 17.43 ? 8 VAL A CA 1 ATOM 50 C C . VAL A 1 8 ? 41.098 11.699 14.814 1.00 17.25 ? 8 VAL A C 1 ATOM 51 O O . VAL A 1 8 ? 40.501 11.288 13.817 1.00 16.67 ? 8 VAL A O 1 ATOM 52 C CB . VAL A 1 8 ? 42.195 13.969 14.634 1.00 18.14 ? 8 VAL A CB 1 ATOM 53 C CG1 . VAL A 1 8 ? 43.544 14.759 14.525 1.00 19.64 ? 8 VAL A CG1 1 ATOM 54 C CG2 . VAL A 1 8 ? 41.263 14.340 13.488 1.00 16.23 ? 8 VAL A CG2 1 ATOM 55 N N . GLU A 1 9 ? 40.623 11.581 16.035 1.00 17.36 ? 9 GLU A N 1 ATOM 56 C CA . GLU A 1 9 ? 39.345 10.960 16.306 1.00 18.40 ? 9 GLU A CA 1 ATOM 57 C C . GLU A 1 9 ? 38.317 12.067 16.124 1.00 18.63 ? 9 GLU A C 1 ATOM 58 O O . GLU A 1 9 ? 37.939 12.740 17.072 1.00 19.25 ? 9 GLU A O 1 ATOM 59 C CB . GLU A 1 9 ? 39.368 10.384 17.735 1.00 18.02 ? 9 GLU A CB 1 ATOM 60 C CG . GLU A 1 9 ? 38.137 9.600 18.204 1.00 19.76 ? 9 GLU A CG 1 ATOM 61 C CD . GLU A 1 9 ? 38.460 8.540 19.273 1.00 22.52 ? 9 GLU A CD 1 ATOM 62 O OE1 . GLU A 1 9 ? 37.552 7.802 19.723 1.00 21.79 ? 9 GLU A OE1 1 ATOM 63 O OE2 . GLU A 1 9 ? 39.631 8.412 19.670 1.00 22.93 ? 9 GLU A OE2 1 ATOM 64 N N . LEU A 1 10 ? 37.878 12.269 14.886 1.00 18.78 ? 10 LEU A N 1 ATOM 65 C CA . LEU A 1 10 ? 36.969 13.375 14.548 1.00 17.92 ? 10 LEU A CA 1 ATOM 66 C C . LEU A 1 10 ? 35.509 13.283 15.109 1.00 17.99 ? 10 LEU A C 1 ATOM 67 O O . LEU A 1 10 ? 34.933 14.285 15.528 1.00 18.20 ? 10 LEU A O 1 ATOM 68 C CB . LEU A 1 10 ? 36.962 13.571 13.032 1.00 17.49 ? 10 LEU A CB 1 ATOM 69 C CG . LEU A 1 10 ? 35.965 14.589 12.483 1.00 18.84 ? 10 LEU A CG 1 ATOM 70 C CD1 . LEU A 1 10 ? 36.337 16.017 12.955 1.00 18.05 ? 10 LEU A CD1 1 ATOM 71 C CD2 . LEU A 1 10 ? 35.897 14.481 10.956 1.00 17.56 ? 10 LEU A CD2 1 ATOM 72 N N . PHE A 1 11 ? 34.900 12.102 15.040 1.00 16.41 ? 11 PHE A N 1 ATOM 73 C CA . PHE A 1 11 ? 33.615 11.830 15.649 1.00 15.41 ? 11 PHE A CA 1 ATOM 74 C C . PHE A 1 11 ? 33.958 10.881 16.773 1.00 15.87 ? 11 PHE A C 1 ATOM 75 O O . PHE A 1 11 ? 34.187 9.693 16.545 1.00 16.76 ? 11 PHE A O 1 ATOM 76 C CB . PHE A 1 11 ? 32.727 11.107 14.679 1.00 14.60 ? 11 PHE A CB 1 ATOM 77 C CG . PHE A 1 11 ? 32.301 11.931 13.528 1.00 13.73 ? 11 PHE A CG 1 ATOM 78 C CD1 . PHE A 1 11 ? 31.030 12.466 13.491 1.00 13.40 ? 11 PHE A CD1 1 ATOM 79 C CD2 . PHE A 1 11 ? 33.153 12.148 12.460 1.00 10.71 ? 11 PHE A CD2 1 ATOM 80 C CE1 . PHE A 1 11 ? 30.593 13.203 12.380 1.00 14.17 ? 11 PHE A CE1 1 ATOM 81 C CE2 . PHE A 1 11 ? 32.737 12.871 11.378 1.00 13.59 ? 11 PHE A CE2 1 ATOM 82 C CZ . PHE A 1 11 ? 31.453 13.409 11.328 1.00 12.72 ? 11 PHE A CZ 1 ATOM 83 N N . LYS A 1 12 ? 34.051 11.403 17.986 1.00 16.38 ? 12 LYS A N 1 ATOM 84 C CA . LYS A 1 12 ? 34.541 10.620 19.110 1.00 16.28 ? 12 LYS A CA 1 ATOM 85 C C . LYS A 1 12 ? 33.400 10.078 19.960 1.00 16.02 ? 12 LYS A C 1 ATOM 86 O O . LYS A 1 12 ? 32.659 10.849 20.581 1.00 14.02 ? 12 LYS A O 1 ATOM 87 C CB . LYS A 1 12 ? 35.482 11.472 19.975 1.00 16.37 ? 12 LYS A CB 1 ATOM 88 C CG . LYS A 1 12 ? 36.347 10.723 21.054 1.00 19.41 ? 12 LYS A CG 1 ATOM 89 C CD . LYS A 1 12 ? 37.453 11.680 21.616 1.00 23.92 ? 12 LYS A CD 1 ATOM 90 C CE . LYS A 1 12 ? 38.055 11.227 22.979 1.00 29.13 ? 12 LYS A CE 1 ATOM 91 N NZ . LYS A 1 12 ? 39.050 10.095 22.925 1.00 30.28 ? 12 LYS A NZ 1 ATOM 92 N N . ARG A 1 13 ? 33.306 8.748 20.020 1.00 15.33 ? 13 ARG A N 1 ATOM 93 C CA . ARG A 1 13 ? 32.303 8.074 20.833 1.00 15.51 ? 13 ARG A CA 1 ATOM 94 C C . ARG A 1 13 ? 32.156 8.687 22.252 1.00 16.43 ? 13 ARG A C 1 ATOM 95 O O . ARG A 1 13 ? 33.134 9.131 22.815 1.00 15.43 ? 13 ARG A O 1 ATOM 96 C CB . ARG A 1 13 ? 32.647 6.578 20.920 1.00 15.09 ? 13 ARG A CB 1 ATOM 97 C CG . ARG A 1 13 ? 34.037 6.229 21.520 1.00 12.50 ? 13 ARG A CG 1 ATOM 98 C CD . ARG A 1 13 ? 34.579 4.871 21.022 1.00 9.63 ? 13 ARG A CD 1 ATOM 99 N NE . ARG A 1 13 ? 36.028 4.730 21.208 1.00 12.52 ? 13 ARG A NE 1 ATOM 100 C CZ . ARG A 1 13 ? 36.774 3.853 20.536 1.00 14.90 ? 13 ARG A CZ 1 ATOM 101 N NH1 . ARG A 1 13 ? 36.186 3.036 19.635 1.00 15.19 ? 13 ARG A NH1 1 ATOM 102 N NH2 . ARG A 1 13 ? 38.103 3.817 20.698 1.00 9.37 ? 13 ARG A NH2 1 ATOM 103 N N . LYS A 1 14 ? 30.938 8.707 22.800 1.00 18.03 ? 14 LYS A N 1 ATOM 104 C CA . LYS A 1 14 ? 30.693 9.201 24.160 1.00 20.15 ? 14 LYS A CA 1 ATOM 105 C C . LYS A 1 14 ? 31.532 10.441 24.501 1.00 20.99 ? 14 LYS A C 1 ATOM 106 O O . LYS A 1 14 ? 32.114 10.530 25.582 1.00 21.93 ? 14 LYS A O 1 ATOM 107 C CB . LYS A 1 14 ? 31.010 8.091 25.176 1.00 20.67 ? 14 LYS A CB 1 ATOM 108 C CG . LYS A 1 14 ? 30.388 6.755 24.853 1.00 23.06 ? 14 LYS A CG 1 ATOM 109 C CD . LYS A 1 14 ? 30.573 5.754 25.981 1.00 25.94 ? 14 LYS A CD 1 ATOM 110 C CE . LYS A 1 14 ? 29.598 4.611 25.783 1.00 26.93 ? 14 LYS A CE 1 ATOM 111 N NZ . LYS A 1 14 ? 29.578 3.644 26.905 1.00 28.90 ? 14 LYS A NZ 1 ATOM 112 N N . ASN A 1 15 ? 31.601 11.377 23.572 1.00 21.35 ? 15 ASN A N 1 ATOM 113 C CA . ASN A 1 15 ? 32.436 12.557 23.753 1.00 23.06 ? 15 ASN A CA 1 ATOM 114 C C . ASN A 1 15 ? 31.954 13.628 22.811 1.00 22.48 ? 15 ASN A C 1 ATOM 115 O O . ASN A 1 15 ? 31.431 14.641 23.251 1.00 23.11 ? 15 ASN A O 1 ATOM 116 C CB . ASN A 1 15 ? 33.918 12.221 23.537 1.00 24.00 ? 15 ASN A CB 1 ATOM 117 C CG . ASN A 1 15 ? 34.873 13.357 23.970 1.00 28.97 ? 15 ASN A CG 1 ATOM 118 O OD1 . ASN A 1 15 ? 34.799 14.470 23.463 1.00 31.08 ? 15 ASN A OD1 1 ATOM 119 N ND2 . ASN A 1 15 ? 35.799 13.045 24.888 1.00 37.70 ? 15 ASN A ND2 1 ATOM 120 N N . SER A 1 16 ? 32.090 13.411 21.512 1.00 21.93 ? 16 SER A N 1 ATOM 121 C CA . SER A 1 16 ? 31.597 14.414 20.562 1.00 21.75 ? 16 SER A CA 1 ATOM 122 C C . SER A 1 16 ? 30.099 14.622 20.640 1.00 21.42 ? 16 SER A C 1 ATOM 123 O O . SER A 1 16 ? 29.299 13.705 20.653 1.00 21.54 ? 16 SER A O 1 ATOM 124 C CB . SER A 1 16 ? 32.017 14.119 19.135 1.00 21.42 ? 16 SER A CB 1 ATOM 125 O OG . SER A 1 16 ? 33.420 13.982 19.090 1.00 21.12 ? 16 SER A OG 1 ATOM 126 N N . THR A 1 17 ? 29.750 15.881 20.662 1.00 20.81 ? 17 THR A N 1 ATOM 127 C CA . THR A 1 17 ? 28.400 16.333 20.847 1.00 20.12 ? 17 THR A CA 1 ATOM 128 C C . THR A 1 17 ? 27.787 16.733 19.517 1.00 19.49 ? 17 THR A C 1 ATOM 129 O O . THR A 1 17 ? 28.507 17.157 18.615 1.00 19.21 ? 17 THR A O 1 ATOM 130 C CB . THR A 1 17 ? 28.571 17.545 21.791 1.00 21.06 ? 17 THR A CB 1 ATOM 131 O OG1 . THR A 1 17 ? 28.063 17.224 23.099 1.00 22.60 ? 17 THR A OG1 1 ATOM 132 C CG2 . THR A 1 17 ? 27.848 18.712 21.327 1.00 19.90 ? 17 THR A CG2 1 ATOM 133 N N . VAL A 1 18 ? 26.475 16.554 19.364 1.00 19.14 ? 18 VAL A N 1 ATOM 134 C CA . VAL A 1 18 ? 25.778 17.027 18.167 1.00 19.11 ? 18 VAL A CA 1 ATOM 135 C C . VAL A 1 18 ? 24.560 17.868 18.606 1.00 20.24 ? 18 VAL A C 1 ATOM 136 O O . VAL A 1 18 ? 23.994 17.636 19.680 1.00 20.90 ? 18 VAL A O 1 ATOM 137 C CB . VAL A 1 18 ? 25.294 15.886 17.246 1.00 18.97 ? 18 VAL A CB 1 ATOM 138 C CG1 . VAL A 1 18 ? 26.452 15.011 16.766 1.00 18.90 ? 18 VAL A CG1 1 ATOM 139 C CG2 . VAL A 1 18 ? 24.237 15.060 17.937 1.00 16.80 ? 18 VAL A CG2 1 ATOM 140 N N . PRO A 1 19 ? 24.172 18.864 17.813 1.00 20.27 ? 19 PRO A N 1 ATOM 141 C CA . PRO A 1 19 ? 23.052 19.730 18.208 1.00 20.48 ? 19 PRO A CA 1 ATOM 142 C C . PRO A 1 19 ? 21.715 19.069 18.002 1.00 21.59 ? 19 PRO A C 1 ATOM 143 O O . PRO A 1 19 ? 21.099 19.255 16.976 1.00 21.46 ? 19 PRO A O 1 ATOM 144 C CB . PRO A 1 19 ? 23.171 20.925 17.269 1.00 19.67 ? 19 PRO A CB 1 ATOM 145 C CG . PRO A 1 19 ? 23.902 20.396 16.070 1.00 20.61 ? 19 PRO A CG 1 ATOM 146 C CD . PRO A 1 19 ? 24.802 19.290 16.554 1.00 19.17 ? 19 PRO A CD 1 ATOM 147 N N . PHE A 1 20 ? 21.274 18.308 18.989 1.00 22.87 ? 20 PHE A N 1 ATOM 148 C CA . PHE A 1 20 ? 19.970 17.669 18.965 1.00 23.66 ? 20 PHE A CA 1 ATOM 149 C C . PHE A 1 20 ? 18.810 18.672 19.051 1.00 25.31 ? 20 PHE A C 1 ATOM 150 O O . PHE A 1 20 ? 18.767 19.529 19.931 1.00 25.41 ? 20 PHE A O 1 ATOM 151 C CB . PHE A 1 20 ? 19.894 16.698 20.138 1.00 23.14 ? 20 PHE A CB 1 ATOM 152 C CG . PHE A 1 20 ? 18.639 15.893 20.166 1.00 21.77 ? 20 PHE A CG 1 ATOM 153 C CD1 . PHE A 1 20 ? 18.396 14.941 19.173 1.00 15.98 ? 20 PHE A CD1 1 ATOM 154 C CD2 . PHE A 1 20 ? 17.687 16.111 21.170 1.00 18.32 ? 20 PHE A CD2 1 ATOM 155 C CE1 . PHE A 1 20 ? 17.232 14.201 19.177 1.00 18.67 ? 20 PHE A CE1 1 ATOM 156 C CE2 . PHE A 1 20 ? 16.521 15.382 21.190 1.00 20.43 ? 20 PHE A CE2 1 ATOM 157 C CZ . PHE A 1 20 ? 16.280 14.413 20.181 1.00 21.43 ? 20 PHE A CZ 1 ATOM 158 N N . GLU A 1 21 ? 17.854 18.560 18.139 1.00 27.39 ? 21 GLU A N 1 ATOM 159 C CA . GLU A 1 21 ? 16.712 19.469 18.156 1.00 29.20 ? 21 GLU A CA 1 ATOM 160 C C . GLU A 1 21 ? 15.541 18.801 18.820 1.00 29.74 ? 21 GLU A C 1 ATOM 161 O O . GLU A 1 21 ? 14.955 17.863 18.292 1.00 29.36 ? 21 GLU A O 1 ATOM 162 C CB . GLU A 1 21 ? 16.335 19.921 16.750 1.00 29.48 ? 21 GLU A CB 1 ATOM 163 C CG . GLU A 1 21 ? 15.066 20.766 16.691 1.00 32.70 ? 21 GLU A CG 1 ATOM 164 C CD . GLU A 1 21 ? 14.785 21.321 15.296 1.00 38.28 ? 21 GLU A CD 1 ATOM 165 O OE1 . GLU A 1 21 ? 15.731 21.463 14.475 1.00 38.71 ? 21 GLU A OE1 1 ATOM 166 O OE2 . GLU A 1 21 ? 13.601 21.627 15.017 1.00 41.80 ? 21 GLU A OE2 1 ATOM 167 N N . GLU A 1 22 ? 15.204 19.294 19.998 1.00 31.66 ? 22 GLU A N 1 ATOM 168 C CA . GLU A 1 22 ? 14.113 18.733 20.765 1.00 33.69 ? 22 GLU A CA 1 ATOM 169 C C . GLU A 1 22 ? 12.800 18.982 20.011 1.00 34.30 ? 22 GLU A C 1 ATOM 170 O O . GLU A 1 22 ? 12.738 19.838 19.153 1.00 34.10 ? 22 GLU A O 1 ATOM 171 C CB . GLU A 1 22 ? 14.107 19.326 22.179 1.00 33.64 ? 22 GLU A CB 1 ATOM 172 C CG . GLU A 1 22 ? 13.751 18.324 23.265 1.00 35.75 ? 22 GLU A CG 1 ATOM 173 C CD . GLU A 1 22 ? 14.936 17.540 23.808 1.00 36.93 ? 22 GLU A CD 1 ATOM 174 O OE1 . GLU A 1 22 ? 14.767 16.334 24.089 1.00 39.14 ? 22 GLU A OE1 1 ATOM 175 O OE2 . GLU A 1 22 ? 16.032 18.107 23.966 1.00 37.48 ? 22 GLU A OE2 1 ATOM 176 N N . SER A 1 23 ? 11.767 18.207 20.309 1.00 36.28 ? 23 SER A N 1 ATOM 177 C CA . SER A 1 23 ? 10.483 18.330 19.611 1.00 38.33 ? 23 SER A CA 1 ATOM 178 C C . SER A 1 23 ? 9.888 19.749 19.598 1.00 39.71 ? 23 SER A C 1 ATOM 179 O O . SER A 1 23 ? 9.060 20.071 18.744 1.00 40.33 ? 23 SER A O 1 ATOM 180 C CB . SER A 1 23 ? 9.459 17.342 20.196 1.00 38.32 ? 23 SER A CB 1 ATOM 181 N N . ASN A 1 24 ? 10.299 20.597 20.531 1.00 40.60 ? 24 ASN A N 1 ATOM 182 C CA . ASN A 1 24 ? 9.731 21.936 20.592 1.00 41.97 ? 24 ASN A CA 1 ATOM 183 C C . ASN A 1 24 ? 10.605 22.992 19.932 1.00 41.73 ? 24 ASN A C 1 ATOM 184 O O . ASN A 1 24 ? 10.407 24.200 20.104 1.00 41.38 ? 24 ASN A O 1 ATOM 185 C CB . ASN A 1 24 ? 9.419 22.313 22.037 1.00 42.53 ? 24 ASN A CB 1 ATOM 186 C CG . ASN A 1 24 ? 10.645 22.415 22.886 1.00 45.95 ? 24 ASN A CG 1 ATOM 187 O OD1 . ASN A 1 24 ? 11.748 22.169 22.417 1.00 47.91 ? 24 ASN A OD1 1 ATOM 188 N ND2 . ASN A 1 24 ? 10.458 22.793 24.158 1.00 52.38 ? 24 ASN A ND2 1 ATOM 189 N N . GLY A 1 25 ? 11.595 22.535 19.188 1.00 41.19 ? 25 GLY A N 1 ATOM 190 C CA . GLY A 1 25 ? 12.462 23.473 18.520 1.00 40.83 ? 25 GLY A CA 1 ATOM 191 C C . GLY A 1 25 ? 13.726 23.769 19.297 1.00 40.30 ? 25 GLY A C 1 ATOM 192 O O . GLY A 1 25 ? 14.738 24.125 18.677 1.00 40.46 ? 25 GLY A O 1 ATOM 193 N N . THR A 1 26 ? 13.688 23.632 20.628 1.00 39.32 ? 26 THR A N 1 ATOM 194 C CA . THR A 1 26 ? 14.889 23.885 21.425 1.00 38.99 ? 26 THR A CA 1 ATOM 195 C C . THR A 1 26 ? 16.038 22.918 21.050 1.00 37.92 ? 26 THR A C 1 ATOM 196 O O . THR A 1 26 ? 15.813 21.740 20.744 1.00 37.70 ? 26 THR A O 1 ATOM 197 C CB . THR A 1 26 ? 14.591 23.876 22.946 1.00 39.39 ? 26 THR A CB 1 ATOM 198 O OG1 . THR A 1 26 ? 15.822 23.914 23.675 1.00 40.08 ? 26 THR A OG1 1 ATOM 199 C CG2 . THR A 1 26 ? 14.044 22.554 23.369 1.00 40.81 ? 26 THR A CG2 1 ATOM 200 N N . ILE A 1 27 ? 17.261 23.435 21.059 1.00 36.57 ? 27 ILE A N 1 ATOM 201 C CA . ILE A 1 27 ? 18.408 22.654 20.642 1.00 35.58 ? 27 ILE A CA 1 ATOM 202 C C . ILE A 1 27 ? 19.437 22.438 21.745 1.00 34.05 ? 27 ILE A C 1 ATOM 203 O O . ILE A 1 27 ? 19.946 23.375 22.343 1.00 33.80 ? 27 ILE A O 1 ATOM 204 C CB . ILE A 1 27 ? 19.091 23.241 19.361 1.00 35.53 ? 27 ILE A CB 1 ATOM 205 C CG1 . ILE A 1 27 ? 20.357 24.002 19.723 1.00 37.14 ? 27 ILE A CG1 1 ATOM 206 C CG2 . ILE A 1 27 ? 18.140 24.072 18.519 1.00 36.35 ? 27 ILE A CG2 1 ATOM 207 C CD1 . ILE A 1 27 ? 21.581 23.082 19.943 1.00 38.98 ? 27 ILE A CD1 1 ATOM 208 N N . ARG A 1 28 ? 19.779 21.180 21.969 1.00 32.21 ? 28 ARG A N 1 ATOM 209 C CA . ARG A 1 28 ? 20.716 20.862 23.019 1.00 30.70 ? 28 ARG A CA 1 ATOM 210 C C . ARG A 1 28 ? 21.884 20.063 22.467 1.00 29.51 ? 28 ARG A C 1 ATOM 211 O O . ARG A 1 28 ? 21.711 19.216 21.581 1.00 29.48 ? 28 ARG A O 1 ATOM 212 C CB . ARG A 1 28 ? 19.992 20.069 24.160 1.00 30.04 ? 28 ARG A CB 1 ATOM 213 N N . GLU A 1 29 ? 23.067 20.318 23.013 1.00 27.80 ? 29 GLU A N 1 ATOM 214 C CA . GLU A 1 29 ? 24.243 19.573 22.636 1.00 26.89 ? 29 GLU A CA 1 ATOM 215 C C . GLU A 1 29 ? 24.196 18.245 23.394 1.00 26.36 ? 29 GLU A C 1 ATOM 216 O O . GLU A 1 29 ? 24.356 18.208 24.613 1.00 27.65 ? 29 GLU A O 1 ATOM 217 C CB . GLU A 1 29 ? 25.495 20.373 22.939 1.00 26.24 ? 29 GLU A CB 1 ATOM 218 C CG . GLU A 1 29 ? 25.643 21.614 22.053 1.00 28.91 ? 29 GLU A CG 1 ATOM 219 C CD . GLU A 1 29 ? 25.981 21.310 20.583 1.00 29.75 ? 29 GLU A CD 1 ATOM 220 O OE1 . GLU A 1 29 ? 25.562 22.075 19.679 1.00 29.94 ? 29 GLU A OE1 1 ATOM 221 O OE2 . GLU A 1 29 ? 26.668 20.310 20.318 1.00 26.56 ? 29 GLU A OE2 1 ATOM 222 N N . ARG A 1 30 ? 23.975 17.161 22.657 1.00 24.75 ? 30 ARG A N 1 ATOM 223 C CA . ARG A 1 30 ? 23.780 15.841 23.210 1.00 23.44 ? 30 ARG A CA 1 ATOM 224 C C . ARG A 1 30 ? 24.907 14.870 22.850 1.00 22.71 ? 30 ARG A C 1 ATOM 225 O O . ARG A 1 30 ? 25.302 14.779 21.695 1.00 22.66 ? 30 ARG A O 1 ATOM 226 C CB . ARG A 1 30 ? 22.473 15.311 22.650 1.00 23.47 ? 30 ARG A CB 1 ATOM 227 C CG . ARG A 1 30 ? 22.080 13.926 23.088 1.00 24.83 ? 30 ARG A CG 1 ATOM 228 C CD . ARG A 1 30 ? 20.714 13.533 22.576 1.00 24.32 ? 30 ARG A CD 1 ATOM 229 N NE . ARG A 1 30 ? 20.365 12.140 22.841 1.00 23.85 ? 30 ARG A NE 1 ATOM 230 C CZ . ARG A 1 30 ? 19.140 11.659 22.649 1.00 24.44 ? 30 ARG A CZ 1 ATOM 231 N NH1 . ARG A 1 30 ? 18.178 12.463 22.228 1.00 23.56 ? 30 ARG A NH1 1 ATOM 232 N NH2 . ARG A 1 30 ? 18.864 10.386 22.879 1.00 24.44 ? 30 ARG A NH2 1 ATOM 233 N N . VAL A 1 31 ? 25.408 14.139 23.835 1.00 21.78 ? 31 VAL A N 1 ATOM 234 C CA . VAL A 1 31 ? 26.481 13.198 23.609 1.00 20.74 ? 31 VAL A CA 1 ATOM 235 C C . VAL A 1 31 ? 25.961 12.038 22.802 1.00 20.09 ? 31 VAL A C 1 ATOM 236 O O . VAL A 1 31 ? 24.795 11.714 22.855 1.00 19.21 ? 31 VAL A O 1 ATOM 237 C CB . VAL A 1 31 ? 27.046 12.711 24.934 1.00 21.88 ? 31 VAL A CB 1 ATOM 238 N N . VAL A 1 32 ? 26.842 11.407 22.047 1.00 19.98 ? 32 VAL A N 1 ATOM 239 C CA . VAL A 1 32 ? 26.445 10.303 21.170 1.00 18.91 ? 32 VAL A CA 1 ATOM 240 C C . VAL A 1 32 ? 27.284 9.084 21.415 1.00 18.45 ? 32 VAL A C 1 ATOM 241 O O . VAL A 1 32 ? 28.492 9.151 21.317 1.00 19.19 ? 32 VAL A O 1 ATOM 242 C CB . VAL A 1 32 ? 26.642 10.706 19.686 1.00 18.87 ? 32 VAL A CB 1 ATOM 243 C CG1 . VAL A 1 32 ? 26.320 9.544 18.766 1.00 16.81 ? 32 VAL A CG1 1 ATOM 244 C CG2 . VAL A 1 32 ? 25.784 11.915 19.375 1.00 18.51 ? 32 VAL A CG2 1 ATOM 245 N N . HIS A 1 33 ? 26.641 7.957 21.678 1.00 18.24 ? 33 HIS A N 1 ATOM 246 C CA . HIS A 1 33 ? 27.329 6.704 21.960 1.00 17.73 ? 33 HIS A CA 1 ATOM 247 C C . HIS A 1 33 ? 28.312 6.254 20.859 1.00 16.76 ? 33 HIS A C 1 ATOM 248 O O . HIS A 1 33 ? 29.479 6.072 21.104 1.00 17.19 ? 33 HIS A O 1 ATOM 249 C CB . HIS A 1 33 ? 26.285 5.605 22.229 1.00 18.09 ? 33 HIS A CB 1 ATOM 250 C CG . HIS A 1 33 ? 26.873 4.258 22.533 1.00 19.64 ? 33 HIS A CG 1 ATOM 251 N ND1 . HIS A 1 33 ? 27.344 3.408 21.551 1.00 19.22 ? 33 HIS A ND1 1 ATOM 252 C CD2 . HIS A 1 33 ? 27.023 3.593 23.710 1.00 20.71 ? 33 HIS A CD2 1 ATOM 253 C CE1 . HIS A 1 33 ? 27.759 2.280 22.108 1.00 20.90 ? 33 HIS A CE1 1 ATOM 254 N NE2 . HIS A 1 33 ? 27.596 2.376 23.420 1.00 19.50 ? 33 HIS A NE2 1 ATOM 255 N N . SER A 1 34 ? 27.839 6.070 19.646 1.00 16.74 ? 34 SER A N 1 ATOM 256 C CA . SER A 1 34 ? 28.697 5.610 18.568 1.00 15.52 ? 34 SER A CA 1 ATOM 257 C C . SER A 1 34 ? 28.407 6.390 17.297 1.00 15.12 ? 34 SER A C 1 ATOM 258 O O . SER A 1 34 ? 27.248 6.741 17.026 1.00 16.19 ? 34 SER A O 1 ATOM 259 C CB . SER A 1 34 ? 28.418 4.131 18.288 1.00 15.50 ? 34 SER A CB 1 ATOM 260 O OG . SER A 1 34 ? 28.805 3.293 19.374 1.00 15.03 ? 34 SER A OG 1 ATOM 261 N N . PHE A 1 35 ? 29.449 6.617 16.495 1.00 13.33 ? 35 PHE A N 1 ATOM 262 C CA . PHE A 1 35 ? 29.321 7.284 15.204 1.00 12.23 ? 35 PHE A CA 1 ATOM 263 C C . PHE A 1 35 ? 29.731 6.200 14.231 1.00 11.98 ? 35 PHE A C 1 ATOM 264 O O . PHE A 1 35 ? 30.820 5.660 14.365 1.00 10.96 ? 35 PHE A O 1 ATOM 265 C CB . PHE A 1 35 ? 30.267 8.487 15.099 1.00 11.66 ? 35 PHE A CB 1 ATOM 266 C CG . PHE A 1 35 ? 29.798 9.688 15.889 1.00 12.27 ? 35 PHE A CG 1 ATOM 267 C CD1 . PHE A 1 35 ? 30.326 9.960 17.127 1.00 9.12 ? 35 PHE A CD1 1 ATOM 268 C CD2 . PHE A 1 35 ? 28.826 10.537 15.376 1.00 12.76 ? 35 PHE A CD2 1 ATOM 269 C CE1 . PHE A 1 35 ? 29.904 11.075 17.855 1.00 12.67 ? 35 PHE A CE1 1 ATOM 270 C CE2 . PHE A 1 35 ? 28.371 11.628 16.118 1.00 13.28 ? 35 PHE A CE2 1 ATOM 271 C CZ . PHE A 1 35 ? 28.917 11.894 17.348 1.00 12.19 ? 35 PHE A CZ 1 ATOM 272 N N . ARG A 1 36 ? 28.838 5.846 13.304 1.00 11.92 ? 36 ARG A N 1 ATOM 273 C CA . ARG A 1 36 ? 29.054 4.756 12.374 1.00 11.97 ? 36 ARG A CA 1 ATOM 274 C C . ARG A 1 36 ? 28.736 5.166 10.927 1.00 12.37 ? 36 ARG A C 1 ATOM 275 O O . ARG A 1 36 ? 28.168 6.238 10.712 1.00 12.06 ? 36 ARG A O 1 ATOM 276 C CB . ARG A 1 36 ? 28.154 3.602 12.778 1.00 12.19 ? 36 ARG A CB 1 ATOM 277 C CG . ARG A 1 36 ? 28.677 2.763 14.001 1.00 13.87 ? 36 ARG A CG 1 ATOM 278 C CD . ARG A 1 36 ? 28.328 1.256 13.961 1.00 14.40 ? 36 ARG A CD 1 ATOM 279 N NE . ARG A 1 36 ? 28.980 0.607 12.804 1.00 15.94 ? 36 ARG A NE 1 ATOM 280 C CZ . ARG A 1 36 ? 28.583 -0.545 12.264 1.00 15.43 ? 36 ARG A CZ 1 ATOM 281 N NH1 . ARG A 1 36 ? 29.190 -1.026 11.194 1.00 18.36 ? 36 ARG A NH1 1 ATOM 282 N NH2 . ARG A 1 36 ? 27.575 -1.224 12.788 1.00 14.91 ? 36 ARG A NH2 1 ATOM 283 N N . ILE A 1 37 ? 29.104 4.317 9.957 1.00 11.55 ? 37 ILE A N 1 ATOM 284 C CA . ILE A 1 37 ? 28.671 4.475 8.580 1.00 11.19 ? 37 ILE A CA 1 ATOM 285 C C . ILE A 1 37 ? 29.118 5.810 7.981 1.00 12.44 ? 37 ILE A C 1 ATOM 286 O O . ILE A 1 37 ? 28.289 6.608 7.550 1.00 11.32 ? 37 ILE A O 1 ATOM 287 C CB . ILE A 1 37 ? 27.143 4.376 8.461 1.00 11.75 ? 37 ILE A CB 1 ATOM 288 C CG1 . ILE A 1 37 ? 26.492 3.370 9.460 1.00 11.69 ? 37 ILE A CG1 1 ATOM 289 C CG2 . ILE A 1 37 ? 26.725 4.010 7.034 1.00 8.80 ? 37 ILE A CG2 1 ATOM 290 C CD1 . ILE A 1 37 ? 26.991 1.894 9.320 1.00 10.98 ? 37 ILE A CD1 1 ATOM 291 N N . PRO A 1 38 ? 30.425 6.050 7.949 1.00 12.17 ? 38 PRO A N 1 ATOM 292 C CA . PRO A 1 38 ? 30.959 7.326 7.440 1.00 12.69 ? 38 PRO A CA 1 ATOM 293 C C . PRO A 1 38 ? 31.029 7.492 5.936 1.00 12.63 ? 38 PRO A C 1 ATOM 294 O O . PRO A 1 38 ? 31.144 6.539 5.198 1.00 14.09 ? 38 PRO A O 1 ATOM 295 C CB . PRO A 1 38 ? 32.414 7.326 7.927 1.00 12.46 ? 38 PRO A CB 1 ATOM 296 C CG . PRO A 1 38 ? 32.826 5.862 7.988 1.00 12.89 ? 38 PRO A CG 1 ATOM 297 C CD . PRO A 1 38 ? 31.483 5.122 8.406 1.00 12.64 ? 38 PRO A CD 1 ATOM 298 N N . THR A 1 39 ? 30.980 8.739 5.511 1.00 12.56 ? 39 THR A N 1 ATOM 299 C CA . THR A 1 39 ? 31.313 9.139 4.153 1.00 11.85 ? 39 THR A CA 1 ATOM 300 C C . THR A 1 39 ? 31.881 10.546 4.249 1.00 10.94 ? 39 THR A C 1 ATOM 301 O O . THR A 1 39 ? 31.324 11.410 4.911 1.00 10.59 ? 39 THR A O 1 ATOM 302 C CB . THR A 1 39 ? 30.057 9.161 3.249 1.00 12.00 ? 39 THR A CB 1 ATOM 303 O OG1 . THR A 1 39 ? 29.590 7.829 3.110 1.00 10.96 ? 39 THR A OG1 1 ATOM 304 C CG2 . THR A 1 39 ? 30.456 9.557 1.791 1.00 11.52 ? 39 THR A CG2 1 ATOM 305 N N . ILE A 1 40 ? 32.986 10.765 3.579 1.00 11.43 ? 40 ILE A N 1 ATOM 306 C CA . ILE A 1 40 ? 33.555 12.080 3.475 1.00 11.42 ? 40 ILE A CA 1 ATOM 307 C C . ILE A 1 40 ? 33.701 12.435 1.996 1.00 11.99 ? 40 ILE A C 1 ATOM 308 O O . ILE A 1 40 ? 34.286 11.687 1.218 1.00 11.59 ? 40 ILE A O 1 ATOM 309 C CB . ILE A 1 40 ? 34.884 12.191 4.187 1.00 12.87 ? 40 ILE A CB 1 ATOM 310 C CG1 . ILE A 1 40 ? 35.336 13.660 4.204 1.00 13.98 ? 40 ILE A CG1 1 ATOM 311 C CG2 . ILE A 1 40 ? 35.936 11.380 3.473 1.00 10.93 ? 40 ILE A CG2 1 ATOM 312 C CD1 . ILE A 1 40 ? 36.368 13.984 5.222 1.00 17.58 ? 40 ILE A CD1 1 ATOM 313 N N . VAL A 1 41 ? 33.086 13.554 1.602 1.00 12.33 ? 41 VAL A N 1 ATOM 314 C CA . VAL A 1 41 ? 33.175 14.052 0.224 1.00 12.75 ? 41 VAL A CA 1 ATOM 315 C C . VAL A 1 41 ? 33.663 15.491 0.162 1.00 14.87 ? 41 VAL A C 1 ATOM 316 O O . VAL A 1 41 ? 33.934 16.116 1.188 1.00 14.43 ? 41 VAL A O 1 ATOM 317 C CB . VAL A 1 41 ? 31.862 13.965 -0.519 1.00 13.56 ? 41 VAL A CB 1 ATOM 318 C CG1 . VAL A 1 41 ? 31.461 12.492 -0.743 1.00 12.39 ? 41 VAL A CG1 1 ATOM 319 C CG2 . VAL A 1 41 ? 30.730 14.701 0.246 1.00 11.44 ? 41 VAL A CG2 1 ATOM 320 N N . ASN A 1 42 ? 33.817 15.996 -1.057 1.00 16.43 ? 42 ASN A N 1 ATOM 321 C CA . ASN A 1 42 ? 34.301 17.355 -1.286 1.00 17.29 ? 42 ASN A CA 1 ATOM 322 C C . ASN A 1 42 ? 33.250 18.135 -2.045 1.00 17.30 ? 42 ASN A C 1 ATOM 323 O O . ASN A 1 42 ? 32.922 17.791 -3.147 1.00 16.64 ? 42 ASN A O 1 ATOM 324 C CB . ASN A 1 42 ? 35.537 17.319 -2.167 1.00 17.57 ? 42 ASN A CB 1 ATOM 325 C CG . ASN A 1 42 ? 35.949 18.719 -2.670 1.00 19.73 ? 42 ASN A CG 1 ATOM 326 O OD1 . ASN A 1 42 ? 35.621 19.748 -2.057 1.00 17.96 ? 42 ASN A OD1 1 ATOM 327 N ND2 . ASN A 1 42 ? 36.727 18.751 -3.748 1.00 18.71 ? 42 ASN A ND2 1 ATOM 328 N N . VAL A 1 43 ? 32.716 19.185 -1.452 1.00 19.02 ? 43 VAL A N 1 ATOM 329 C CA . VAL A 1 43 ? 31.719 19.979 -2.148 1.00 19.85 ? 43 VAL A CA 1 ATOM 330 C C . VAL A 1 43 ? 32.340 21.336 -2.427 1.00 21.04 ? 43 VAL A C 1 ATOM 331 O O . VAL A 1 43 ? 32.627 22.113 -1.501 1.00 20.12 ? 43 VAL A O 1 ATOM 332 C CB . VAL A 1 43 ? 30.418 20.120 -1.346 1.00 19.61 ? 43 VAL A CB 1 ATOM 333 C CG1 . VAL A 1 43 ? 29.358 20.819 -2.178 1.00 20.88 ? 43 VAL A CG1 1 ATOM 334 C CG2 . VAL A 1 43 ? 29.886 18.744 -0.951 1.00 19.46 ? 43 VAL A CG2 1 ATOM 335 N N . ASP A 1 44 ? 32.668 21.563 -3.696 1.00 22.51 ? 44 ASP A N 1 ATOM 336 C CA . ASP A 1 44 ? 33.088 22.885 -4.077 1.00 24.15 ? 44 ASP A CA 1 ATOM 337 C C . ASP A 1 44 ? 34.157 23.396 -3.116 1.00 23.33 ? 44 ASP A C 1 ATOM 338 O O . ASP A 1 44 ? 34.088 24.522 -2.688 1.00 24.14 ? 44 ASP A O 1 ATOM 339 C CB . ASP A 1 44 ? 31.827 23.746 -3.908 1.00 25.22 ? 44 ASP A CB 1 ATOM 340 C CG . ASP A 1 44 ? 31.863 25.044 -4.667 1.00 30.27 ? 44 ASP A CG 1 ATOM 341 O OD1 . ASP A 1 44 ? 32.891 25.767 -4.669 1.00 34.02 ? 44 ASP A OD1 1 ATOM 342 O OD2 . ASP A 1 44 ? 30.840 25.447 -5.258 1.00 36.59 ? 44 ASP A OD2 1 ATOM 343 N N . GLY A 1 45 ? 35.112 22.576 -2.725 1.00 22.34 ? 45 GLY A N 1 ATOM 344 C CA . GLY A 1 45 ? 36.160 23.069 -1.847 1.00 21.99 ? 45 GLY A CA 1 ATOM 345 C C . GLY A 1 45 ? 35.937 22.868 -0.356 1.00 21.15 ? 45 GLY A C 1 ATOM 346 O O . GLY A 1 45 ? 36.852 23.088 0.438 1.00 21.11 ? 45 GLY A O 1 ATOM 347 N N . VAL A 1 46 ? 34.729 22.454 0.028 1.00 20.44 ? 46 VAL A N 1 ATOM 348 C CA . VAL A 1 46 ? 34.419 22.204 1.435 1.00 19.43 ? 46 VAL A CA 1 ATOM 349 C C . VAL A 1 46 ? 34.323 20.700 1.750 1.00 20.01 ? 46 VAL A C 1 ATOM 350 O O . VAL A 1 46 ? 33.539 19.990 1.112 1.00 19.64 ? 46 VAL A O 1 ATOM 351 C CB . VAL A 1 46 ? 33.021 22.815 1.789 1.00 19.99 ? 46 VAL A CB 1 ATOM 352 C CG1 . VAL A 1 46 ? 32.612 22.473 3.212 1.00 18.12 ? 46 VAL A CG1 1 ATOM 353 C CG2 . VAL A 1 46 ? 33.009 24.319 1.572 1.00 18.79 ? 46 VAL A CG2 1 ATOM 354 N N . MET A 1 47 ? 35.078 20.221 2.741 1.00 19.49 ? 47 MET A N 1 ATOM 355 C CA . MET A 1 47 ? 34.989 18.814 3.139 1.00 19.16 ? 47 MET A CA 1 ATOM 356 C C . MET A 1 47 ? 33.704 18.610 3.870 1.00 18.31 ? 47 MET A C 1 ATOM 357 O O . MET A 1 47 ? 33.393 19.384 4.748 1.00 18.55 ? 47 MET A O 1 ATOM 358 C CB . MET A 1 47 ? 36.097 18.434 4.108 1.00 19.68 ? 47 MET A CB 1 ATOM 359 C CG . MET A 1 47 ? 37.429 18.195 3.476 1.00 20.19 ? 47 MET A CG 1 ATOM 360 S SD . MET A 1 47 ? 38.643 17.696 4.677 1.00 22.23 ? 47 MET A SD 1 ATOM 361 C CE . MET A 1 47 ? 40.096 17.556 3.560 1.00 19.54 ? 47 MET A CE 1 ATOM 362 N N . VAL A 1 48 ? 32.973 17.558 3.516 1.00 17.78 ? 48 VAL A N 1 ATOM 363 C CA . VAL A 1 48 ? 31.717 17.215 4.168 1.00 16.69 ? 48 VAL A CA 1 ATOM 364 C C . VAL A 1 48 ? 31.764 15.739 4.588 1.00 16.28 ? 48 VAL A C 1 ATOM 365 O O . VAL A 1 48 ? 31.913 14.814 3.751 1.00 15.62 ? 48 VAL A O 1 ATOM 366 C CB . VAL A 1 48 ? 30.501 17.488 3.269 1.00 16.50 ? 48 VAL A CB 1 ATOM 367 C CG1 . VAL A 1 48 ? 29.194 17.477 4.077 1.00 15.31 ? 48 VAL A CG1 1 ATOM 368 C CG2 . VAL A 1 48 ? 30.647 18.852 2.602 1.00 17.87 ? 48 VAL A CG2 1 ATOM 369 N N . ALA A 1 49 ? 31.663 15.553 5.903 1.00 15.41 ? 49 ALA A N 1 ATOM 370 C CA . ALA A 1 49 ? 31.737 14.255 6.559 1.00 14.84 ? 49 ALA A CA 1 ATOM 371 C C . ALA A 1 49 ? 30.335 13.924 7.092 1.00 15.09 ? 49 ALA A C 1 ATOM 372 O O . ALA A 1 49 ? 29.786 14.684 7.890 1.00 14.38 ? 49 ALA A O 1 ATOM 373 C CB . ALA A 1 49 ? 32.709 14.326 7.670 1.00 13.79 ? 49 ALA A CB 1 ATOM 374 N N . THR A 1 50 ? 29.761 12.822 6.597 1.00 14.94 ? 50 THR A N 1 ATOM 375 C CA . THR A 1 50 ? 28.405 12.430 6.897 1.00 14.39 ? 50 THR A CA 1 ATOM 376 C C . THR A 1 50 ? 28.487 11.153 7.716 1.00 15.08 ? 50 THR A C 1 ATOM 377 O O . THR A 1 50 ? 29.355 10.286 7.471 1.00 15.52 ? 50 THR A O 1 ATOM 378 C CB . THR A 1 50 ? 27.652 12.156 5.578 1.00 15.43 ? 50 THR A CB 1 ATOM 379 O OG1 . THR A 1 50 ? 27.551 13.365 4.777 1.00 18.10 ? 50 THR A OG1 1 ATOM 380 C CG2 . THR A 1 50 ? 26.175 11.739 5.827 1.00 11.87 ? 50 THR A CG2 1 ATOM 381 N N . ALA A 1 51 ? 27.603 11.008 8.691 1.00 14.34 ? 51 ALA A N 1 ATOM 382 C CA . ALA A 1 51 ? 27.632 9.794 9.491 1.00 14.44 ? 51 ALA A CA 1 ATOM 383 C C . ALA A 1 51 ? 26.349 9.541 10.266 1.00 14.16 ? 51 ALA A C 1 ATOM 384 O O . ALA A 1 51 ? 25.541 10.453 10.439 1.00 14.37 ? 51 ALA A O 1 ATOM 385 C CB . ALA A 1 51 ? 28.787 9.855 10.444 1.00 14.62 ? 51 ALA A CB 1 ATOM 386 N N . ASP A 1 52 ? 26.149 8.288 10.689 1.00 13.88 ? 52 ASP A N 1 ATOM 387 C CA . ASP A 1 52 ? 25.054 7.945 11.611 1.00 13.47 ? 52 ASP A CA 1 ATOM 388 C C . ASP A 1 52 ? 25.474 8.468 12.997 1.00 13.67 ? 52 ASP A C 1 ATOM 389 O O . ASP A 1 52 ? 26.575 8.087 13.475 1.00 12.41 ? 52 ASP A O 1 ATOM 390 C CB . ASP A 1 52 ? 24.991 6.434 11.840 1.00 13.35 ? 52 ASP A CB 1 ATOM 391 C CG . ASP A 1 52 ? 24.119 5.689 10.852 1.00 13.64 ? 52 ASP A CG 1 ATOM 392 O OD1 . ASP A 1 52 ? 23.789 6.228 9.783 1.00 10.62 ? 52 ASP A OD1 1 ATOM 393 O OD2 . ASP A 1 52 ? 23.723 4.517 11.104 1.00 14.50 ? 52 ASP A OD2 1 ATOM 394 N N . ALA A 1 53 ? 24.629 9.274 13.652 1.00 12.57 ? 53 ALA A N 1 ATOM 395 C CA . ALA A 1 53 ? 24.818 9.518 15.085 1.00 13.10 ? 53 ALA A CA 1 ATOM 396 C C . ALA A 1 53 ? 23.943 8.523 15.847 1.00 13.70 ? 53 ALA A C 1 ATOM 397 O O . ALA A 1 53 ? 22.730 8.728 15.968 1.00 13.94 ? 53 ALA A O 1 ATOM 398 C CB . ALA A 1 53 ? 24.435 10.940 15.462 1.00 13.03 ? 53 ALA A CB 1 ATOM 399 N N . ARG A 1 54 ? 24.531 7.458 16.371 1.00 14.04 ? 54 ARG A N 1 ATOM 400 C CA . ARG A 1 54 ? 23.761 6.459 17.114 1.00 14.86 ? 54 ARG A CA 1 ATOM 401 C C . ARG A 1 54 ? 23.817 6.891 18.584 1.00 16.39 ? 54 ARG A C 1 ATOM 402 O O . ARG A 1 54 ? 24.757 6.592 19.332 1.00 16.66 ? 54 ARG A O 1 ATOM 403 C CB . ARG A 1 54 ? 24.320 5.038 16.870 1.00 14.45 ? 54 ARG A CB 1 ATOM 404 C CG . ARG A 1 54 ? 24.313 4.702 15.369 1.00 12.55 ? 54 ARG A CG 1 ATOM 405 C CD . ARG A 1 54 ? 24.570 3.274 15.008 1.00 12.30 ? 54 ARG A CD 1 ATOM 406 N NE . ARG A 1 54 ? 24.424 3.118 13.572 1.00 12.54 ? 54 ARG A NE 1 ATOM 407 C CZ . ARG A 1 54 ? 24.320 1.951 12.974 1.00 12.25 ? 54 ARG A CZ 1 ATOM 408 N NH1 . ARG A 1 54 ? 24.382 0.827 13.696 1.00 11.70 ? 54 ARG A NH1 1 ATOM 409 N NH2 . ARG A 1 54 ? 24.129 1.906 11.675 1.00 10.23 ? 54 ARG A NH2 1 ATOM 410 N N . TYR A 1 55 ? 22.786 7.607 18.986 1.00 17.24 ? 55 TYR A N 1 ATOM 411 C CA . TYR A 1 55 ? 22.825 8.316 20.254 1.00 18.16 ? 55 TYR A CA 1 ATOM 412 C C . TYR A 1 55 ? 23.020 7.467 21.476 1.00 18.43 ? 55 TYR A C 1 ATOM 413 O O . TYR A 1 55 ? 23.801 7.843 22.337 1.00 18.35 ? 55 TYR A O 1 ATOM 414 C CB . TYR A 1 55 ? 21.552 9.140 20.448 1.00 17.07 ? 55 TYR A CB 1 ATOM 415 C CG . TYR A 1 55 ? 21.388 10.351 19.555 1.00 18.41 ? 55 TYR A CG 1 ATOM 416 C CD1 . TYR A 1 55 ? 20.708 10.267 18.338 1.00 18.06 ? 55 TYR A CD1 1 ATOM 417 C CD2 . TYR A 1 55 ? 21.880 11.594 19.936 1.00 18.19 ? 55 TYR A CD2 1 ATOM 418 C CE1 . TYR A 1 55 ? 20.516 11.389 17.545 1.00 18.08 ? 55 TYR A CE1 1 ATOM 419 C CE2 . TYR A 1 55 ? 21.699 12.728 19.126 1.00 16.56 ? 55 TYR A CE2 1 ATOM 420 C CZ . TYR A 1 55 ? 21.027 12.618 17.944 1.00 17.10 ? 55 TYR A CZ 1 ATOM 421 O OH . TYR A 1 55 ? 20.830 13.754 17.169 1.00 19.00 ? 55 TYR A OH 1 ATOM 422 N N . GLU A 1 56 ? 22.336 6.322 21.529 1.00 19.05 ? 56 GLU A N 1 ATOM 423 C CA . GLU A 1 56 ? 22.242 5.543 22.763 1.00 20.46 ? 56 GLU A CA 1 ATOM 424 C C . GLU A 1 56 ? 23.035 4.256 22.753 1.00 20.77 ? 56 GLU A C 1 ATOM 425 O O . GLU A 1 56 ? 23.482 3.787 23.798 1.00 20.39 ? 56 GLU A O 1 ATOM 426 C CB . GLU A 1 56 ? 20.759 5.197 23.051 1.00 20.36 ? 56 GLU A CB 1 ATOM 427 C CG . GLU A 1 56 ? 19.851 6.410 23.264 1.00 22.90 ? 56 GLU A CG 1 ATOM 428 C CD . GLU A 1 56 ? 20.432 7.347 24.283 1.00 26.46 ? 56 GLU A CD 1 ATOM 429 O OE1 . GLU A 1 56 ? 20.726 6.811 25.381 1.00 27.06 ? 56 GLU A OE1 1 ATOM 430 O OE2 . GLU A 1 56 ? 20.628 8.571 23.982 1.00 25.07 ? 56 GLU A OE2 1 ATOM 431 N N . THR A 1 57 ? 23.181 3.667 21.574 1.00 21.18 ? 57 THR A N 1 ATOM 432 C CA . THR A 1 57 ? 23.873 2.392 21.453 1.00 21.68 ? 57 THR A CA 1 ATOM 433 C C . THR A 1 57 ? 24.429 2.227 20.026 1.00 20.87 ? 57 THR A C 1 ATOM 434 O O . THR A 1 57 ? 24.035 2.954 19.146 1.00 21.49 ? 57 THR A O 1 ATOM 435 C CB . THR A 1 57 ? 22.865 1.281 21.794 1.00 22.01 ? 57 THR A CB 1 ATOM 436 O OG1 . THR A 1 57 ? 23.374 0.031 21.350 1.00 25.74 ? 57 THR A OG1 1 ATOM 437 C CG2 . THR A 1 57 ? 21.647 1.396 20.938 1.00 21.82 ? 57 THR A CG2 1 ATOM 438 N N . SER A 1 58 ? 25.312 1.273 19.776 1.00 20.50 ? 58 SER A N 1 ATOM 439 C CA . SER A 1 58 ? 25.824 1.094 18.423 1.00 20.87 ? 58 SER A CA 1 ATOM 440 C C . SER A 1 58 ? 24.883 0.266 17.570 1.00 21.65 ? 58 SER A C 1 ATOM 441 O O . SER A 1 58 ? 25.091 0.108 16.364 1.00 20.56 ? 58 SER A O 1 ATOM 442 C CB . SER A 1 58 ? 27.180 0.404 18.461 1.00 20.91 ? 58 SER A CB 1 ATOM 443 O OG . SER A 1 58 ? 27.027 -0.877 19.043 1.00 22.52 ? 58 SER A OG 1 ATOM 444 N N . PHE A 1 59 ? 23.827 -0.259 18.180 1.00 22.79 ? 59 PHE A N 1 ATOM 445 C CA . PHE A 1 59 ? 22.923 -1.116 17.427 1.00 24.35 ? 59 PHE A CA 1 ATOM 446 C C . PHE A 1 59 ? 22.125 -0.493 16.297 1.00 24.04 ? 59 PHE A C 1 ATOM 447 O O . PHE A 1 59 ? 21.705 0.659 16.346 1.00 23.91 ? 59 PHE A O 1 ATOM 448 C CB . PHE A 1 59 ? 22.013 -1.918 18.357 1.00 25.59 ? 59 PHE A CB 1 ATOM 449 C CG . PHE A 1 59 ? 22.758 -2.976 19.123 1.00 30.09 ? 59 PHE A CG 1 ATOM 450 C CD1 . PHE A 1 59 ? 23.632 -3.831 18.451 1.00 33.47 ? 59 PHE A CD1 1 ATOM 451 C CD2 . PHE A 1 59 ? 22.628 -3.088 20.494 1.00 33.24 ? 59 PHE A CD2 1 ATOM 452 C CE1 . PHE A 1 59 ? 24.343 -4.797 19.130 1.00 34.04 ? 59 PHE A CE1 1 ATOM 453 C CE2 . PHE A 1 59 ? 23.333 -4.058 21.186 1.00 36.79 ? 59 PHE A CE2 1 ATOM 454 C CZ . PHE A 1 59 ? 24.200 -4.910 20.493 1.00 36.15 ? 59 PHE A CZ 1 ATOM 455 N N . ASP A 1 60 ? 21.901 -1.309 15.276 1.00 23.81 ? 60 ASP A N 1 ATOM 456 C CA . ASP A 1 60 ? 21.154 -0.883 14.111 1.00 24.13 ? 60 ASP A CA 1 ATOM 457 C C . ASP A 1 60 ? 19.737 -0.435 14.465 1.00 23.48 ? 60 ASP A C 1 ATOM 458 O O . ASP A 1 60 ? 19.215 0.503 13.894 1.00 23.39 ? 60 ASP A O 1 ATOM 459 C CB . ASP A 1 60 ? 21.116 -2.006 13.089 1.00 23.54 ? 60 ASP A CB 1 ATOM 460 C CG . ASP A 1 60 ? 22.405 -2.107 12.303 1.00 26.02 ? 60 ASP A CG 1 ATOM 461 O OD1 . ASP A 1 60 ? 22.321 -2.565 11.143 1.00 28.54 ? 60 ASP A OD1 1 ATOM 462 O OD2 . ASP A 1 60 ? 23.537 -1.722 12.736 1.00 23.58 ? 60 ASP A OD2 1 ATOM 463 N N . ASN A 1 61 ? 19.136 -1.098 15.430 1.00 23.12 ? 61 ASN A N 1 ATOM 464 C CA . ASN A 1 61 ? 17.730 -0.866 15.717 1.00 23.84 ? 61 ASN A CA 1 ATOM 465 C C . ASN A 1 61 ? 17.547 0.018 16.890 1.00 22.93 ? 61 ASN A C 1 ATOM 466 O O . ASN A 1 61 ? 16.879 -0.368 17.824 1.00 24.63 ? 61 ASN A O 1 ATOM 467 C CB . ASN A 1 61 ? 17.059 -2.195 16.043 1.00 24.04 ? 61 ASN A CB 1 ATOM 468 C CG . ASN A 1 61 ? 16.700 -2.976 14.814 1.00 25.48 ? 61 ASN A CG 1 ATOM 469 O OD1 . ASN A 1 61 ? 15.636 -2.765 14.244 1.00 31.05 ? 61 ASN A OD1 1 ATOM 470 N ND2 . ASN A 1 61 ? 17.553 -3.904 14.414 1.00 25.79 ? 61 ASN A ND2 1 ATOM 471 N N . SER A 1 62 ? 18.163 1.184 16.870 1.00 21.79 ? 62 SER A N 1 ATOM 472 C CA . SER A 1 62 ? 18.102 2.095 18.004 1.00 19.52 ? 62 SER A CA 1 ATOM 473 C C . SER A 1 62 ? 17.882 3.529 17.485 1.00 18.87 ? 62 SER A C 1 ATOM 474 O O . SER A 1 62 ? 17.692 3.726 16.277 1.00 17.92 ? 62 SER A O 1 ATOM 475 C CB . SER A 1 62 ? 19.390 1.980 18.809 1.00 19.76 ? 62 SER A CB 1 ATOM 476 O OG . SER A 1 62 ? 20.488 2.493 18.090 1.00 19.59 ? 62 SER A OG 1 ATOM 477 N N . PHE A 1 63 ? 17.911 4.508 18.389 1.00 17.60 ? 63 PHE A N 1 ATOM 478 C CA . PHE A 1 63 ? 17.618 5.922 18.071 1.00 17.45 ? 63 PHE A CA 1 ATOM 479 C C . PHE A 1 63 ? 18.777 6.549 17.275 1.00 16.94 ? 63 PHE A C 1 ATOM 480 O O . PHE A 1 63 ? 19.837 6.760 17.832 1.00 17.07 ? 63 PHE A O 1 ATOM 481 C CB . PHE A 1 63 ? 17.378 6.703 19.388 1.00 16.69 ? 63 PHE A CB 1 ATOM 482 C CG . PHE A 1 63 ? 16.747 8.093 19.204 1.00 17.69 ? 63 PHE A CG 1 ATOM 483 C CD1 . PHE A 1 63 ? 15.410 8.229 18.858 1.00 14.16 ? 63 PHE A CD1 1 ATOM 484 C CD2 . PHE A 1 63 ? 17.505 9.259 19.401 1.00 15.91 ? 63 PHE A CD2 1 ATOM 485 C CE1 . PHE A 1 63 ? 14.825 9.503 18.677 1.00 14.86 ? 63 PHE A CE1 1 ATOM 486 C CE2 . PHE A 1 63 ? 16.928 10.535 19.222 1.00 17.99 ? 63 PHE A CE2 1 ATOM 487 C CZ . PHE A 1 63 ? 15.589 10.656 18.863 1.00 16.30 ? 63 PHE A CZ 1 ATOM 488 N N . ILE A 1 64 ? 18.571 6.868 15.988 1.00 16.50 ? 64 ILE A N 1 ATOM 489 C CA . ILE A 1 64 ? 19.649 7.426 15.153 1.00 14.96 ? 64 ILE A CA 1 ATOM 490 C C . ILE A 1 64 ? 19.318 8.630 14.266 1.00 14.63 ? 64 ILE A C 1 ATOM 491 O O . ILE A 1 64 ? 18.248 8.725 13.694 1.00 14.08 ? 64 ILE A O 1 ATOM 492 C CB . ILE A 1 64 ? 20.226 6.324 14.246 1.00 15.34 ? 64 ILE A CB 1 ATOM 493 C CG1 . ILE A 1 64 ? 20.692 5.104 15.083 1.00 14.12 ? 64 ILE A CG1 1 ATOM 494 C CG2 . ILE A 1 64 ? 21.384 6.878 13.423 1.00 13.50 ? 64 ILE A CG2 1 ATOM 495 C CD1 . ILE A 1 64 ? 20.823 3.778 14.219 1.00 12.77 ? 64 ILE A CD1 1 ATOM 496 N N . GLU A 1 65 ? 20.263 9.551 14.122 1.00 14.58 ? 65 GLU A N 1 ATOM 497 C CA . GLU A 1 65 ? 20.052 10.663 13.190 1.00 14.78 ? 65 GLU A CA 1 ATOM 498 C C . GLU A 1 65 ? 21.284 10.819 12.332 1.00 14.67 ? 65 GLU A C 1 ATOM 499 O O . GLU A 1 65 ? 22.325 10.256 12.635 1.00 14.46 ? 65 GLU A O 1 ATOM 500 C CB . GLU A 1 65 ? 19.580 11.981 13.905 1.00 13.90 ? 65 GLU A CB 1 ATOM 501 C CG . GLU A 1 65 ? 18.198 11.815 14.583 1.00 14.51 ? 65 GLU A CG 1 ATOM 502 C CD . GLU A 1 65 ? 17.628 13.110 15.165 1.00 17.19 ? 65 GLU A CD 1 ATOM 503 O OE1 . GLU A 1 65 ? 18.396 13.872 15.787 1.00 15.16 ? 65 GLU A OE1 1 ATOM 504 O OE2 . GLU A 1 65 ? 16.416 13.367 14.974 1.00 15.38 ? 65 GLU A OE2 1 ATOM 505 N N . THR A 1 66 ? 21.156 11.543 11.225 1.00 15.52 ? 66 THR A N 1 ATOM 506 C CA . THR A 1 66 ? 22.309 11.771 10.368 1.00 15.41 ? 66 THR A CA 1 ATOM 507 C C . THR A 1 66 ? 23.092 12.990 10.772 1.00 15.83 ? 66 THR A C 1 ATOM 508 O O . THR A 1 66 ? 22.599 14.104 10.628 1.00 15.55 ? 66 THR A O 1 ATOM 509 C CB . THR A 1 66 ? 21.866 12.004 8.957 1.00 16.00 ? 66 THR A CB 1 ATOM 510 O OG1 . THR A 1 66 ? 21.001 10.938 8.556 1.00 15.62 ? 66 THR A OG1 1 ATOM 511 C CG2 . THR A 1 66 ? 23.071 11.924 8.039 1.00 13.60 ? 66 THR A CG2 1 ATOM 512 N N . ALA A 1 67 ? 24.320 12.793 11.228 1.00 15.67 ? 67 ALA A N 1 ATOM 513 C CA . ALA A 1 67 ? 25.158 13.923 11.573 1.00 17.06 ? 67 ALA A CA 1 ATOM 514 C C . ALA A 1 67 ? 26.040 14.348 10.401 1.00 17.42 ? 67 ALA A C 1 ATOM 515 O O . ALA A 1 67 ? 26.378 13.536 9.526 1.00 17.80 ? 67 ALA A O 1 ATOM 516 C CB . ALA A 1 67 ? 26.041 13.570 12.761 1.00 16.60 ? 67 ALA A CB 1 ATOM 517 N N . VAL A 1 68 ? 26.445 15.612 10.411 1.00 17.14 ? 68 VAL A N 1 ATOM 518 C CA . VAL A 1 68 ? 27.401 16.101 9.456 1.00 17.00 ? 68 VAL A CA 1 ATOM 519 C C . VAL A 1 68 ? 28.407 16.994 10.149 1.00 16.89 ? 68 VAL A C 1 ATOM 520 O O . VAL A 1 68 ? 28.071 17.759 11.038 1.00 17.14 ? 68 VAL A O 1 ATOM 521 C CB . VAL A 1 68 ? 26.765 16.929 8.311 1.00 16.90 ? 68 VAL A CB 1 ATOM 522 C CG1 . VAL A 1 68 ? 25.943 16.073 7.379 1.00 17.77 ? 68 VAL A CG1 1 ATOM 523 C CG2 . VAL A 1 68 ? 25.897 17.930 8.865 1.00 20.66 ? 68 VAL A CG2 1 ATOM 524 N N . LYS A 1 69 ? 29.664 16.880 9.741 1.00 16.49 ? 69 LYS A N 1 ATOM 525 C CA . LYS A 1 69 ? 30.672 17.865 10.098 1.00 16.08 ? 69 LYS A CA 1 ATOM 526 C C . LYS A 1 69 ? 31.225 18.351 8.758 1.00 16.90 ? 69 LYS A C 1 ATOM 527 O O . LYS A 1 69 ? 31.436 17.547 7.852 1.00 17.19 ? 69 LYS A O 1 ATOM 528 C CB . LYS A 1 69 ? 31.804 17.270 10.955 1.00 15.60 ? 69 LYS A CB 1 ATOM 529 C CG . LYS A 1 69 ? 31.411 16.925 12.413 1.00 14.60 ? 69 LYS A CG 1 ATOM 530 C CD . LYS A 1 69 ? 32.554 16.245 13.143 1.00 13.90 ? 69 LYS A CD 1 ATOM 531 C CE . LYS A 1 69 ? 32.208 15.978 14.595 1.00 16.19 ? 69 LYS A CE 1 ATOM 532 N NZ . LYS A 1 69 ? 32.207 17.204 15.435 1.00 14.72 ? 69 LYS A NZ 1 ATOM 533 N N . TYR A 1 70 ? 31.460 19.648 8.601 1.00 17.87 ? 70 TYR A N 1 ATOM 534 C CA . TYR A 1 70 ? 32.055 20.115 7.359 1.00 19.03 ? 70 TYR A CA 1 ATOM 535 C C . TYR A 1 70 ? 33.184 21.035 7.666 1.00 19.72 ? 70 TYR A C 1 ATOM 536 O O . TYR A 1 70 ? 33.250 21.570 8.754 1.00 19.58 ? 70 TYR A O 1 ATOM 537 C CB . TYR A 1 70 ? 31.027 20.795 6.465 1.00 19.77 ? 70 TYR A CB 1 ATOM 538 C CG . TYR A 1 70 ? 30.373 22.010 7.072 1.00 21.78 ? 70 TYR A CG 1 ATOM 539 C CD1 . TYR A 1 70 ? 29.186 21.904 7.771 1.00 22.79 ? 70 TYR A CD1 1 ATOM 540 C CD2 . TYR A 1 70 ? 30.942 23.269 6.936 1.00 24.06 ? 70 TYR A CD2 1 ATOM 541 C CE1 . TYR A 1 70 ? 28.584 23.026 8.312 1.00 25.04 ? 70 TYR A CE1 1 ATOM 542 C CE2 . TYR A 1 70 ? 30.347 24.396 7.472 1.00 25.12 ? 70 TYR A CE2 1 ATOM 543 C CZ . TYR A 1 70 ? 29.174 24.271 8.158 1.00 26.08 ? 70 TYR A CZ 1 ATOM 544 O OH . TYR A 1 70 ? 28.589 25.394 8.702 1.00 27.42 ? 70 TYR A OH 1 ATOM 545 N N . SER A 1 71 ? 34.084 21.238 6.708 1.00 20.60 ? 71 SER A N 1 ATOM 546 C CA . SER A 1 71 ? 35.243 22.082 6.960 1.00 20.85 ? 71 SER A CA 1 ATOM 547 C C . SER A 1 71 ? 35.697 22.783 5.703 1.00 21.64 ? 71 SER A C 1 ATOM 548 O O . SER A 1 71 ? 35.751 22.178 4.629 1.00 21.06 ? 71 SER A O 1 ATOM 549 C CB . SER A 1 71 ? 36.401 21.233 7.480 1.00 21.74 ? 71 SER A CB 1 ATOM 550 O OG . SER A 1 71 ? 37.678 21.900 7.327 1.00 22.00 ? 71 SER A OG 1 ATOM 551 N N . VAL A 1 72 ? 36.071 24.053 5.857 1.00 22.08 ? 72 VAL A N 1 ATOM 552 C CA . VAL A 1 72 ? 36.529 24.868 4.749 1.00 22.32 ? 72 VAL A CA 1 ATOM 553 C C . VAL A 1 72 ? 38.023 24.967 4.767 1.00 22.76 ? 72 VAL A C 1 ATOM 554 O O . VAL A 1 72 ? 38.621 25.639 3.919 1.00 22.66 ? 72 VAL A O 1 ATOM 555 C CB . VAL A 1 72 ? 35.982 26.304 4.839 1.00 22.69 ? 72 VAL A CB 1 ATOM 556 C CG1 . VAL A 1 72 ? 34.478 26.263 4.816 1.00 22.61 ? 72 VAL A CG1 1 ATOM 557 C CG2 . VAL A 1 72 ? 36.496 27.014 6.112 1.00 21.23 ? 72 VAL A CG2 1 ATOM 558 N N . ASP A 1 73 ? 38.647 24.281 5.715 1.00 23.53 ? 73 ASP A N 1 ATOM 559 C CA . ASP A 1 73 ? 40.102 24.376 5.819 1.00 24.66 ? 73 ASP A CA 1 ATOM 560 C C . ASP A 1 73 ? 40.842 23.045 5.877 1.00 24.91 ? 73 ASP A C 1 ATOM 561 O O . ASP A 1 73 ? 41.795 22.898 6.626 1.00 24.77 ? 73 ASP A O 1 ATOM 562 C CB . ASP A 1 73 ? 40.502 25.252 7.008 1.00 24.77 ? 73 ASP A CB 1 ATOM 563 C CG . ASP A 1 73 ? 39.896 24.782 8.316 1.00 26.21 ? 73 ASP A CG 1 ATOM 564 O OD1 . ASP A 1 73 ? 39.520 23.588 8.451 1.00 24.70 ? 73 ASP A OD1 1 ATOM 565 O OD2 . ASP A 1 73 ? 39.743 25.564 9.278 1.00 28.59 ? 73 ASP A OD2 1 ATOM 566 N N . ASP A 1 74 ? 40.380 22.086 5.094 1.00 25.42 ? 74 ASP A N 1 ATOM 567 C CA . ASP A 1 74 ? 41.045 20.803 4.985 1.00 26.39 ? 74 ASP A CA 1 ATOM 568 C C . ASP A 1 74 ? 41.246 20.100 6.307 1.00 26.77 ? 74 ASP A C 1 ATOM 569 O O . ASP A 1 74 ? 42.203 19.345 6.481 1.00 27.01 ? 74 ASP A O 1 ATOM 570 C CB . ASP A 1 74 ? 42.351 20.949 4.200 1.00 26.25 ? 74 ASP A CB 1 ATOM 571 C CG . ASP A 1 74 ? 42.081 21.280 2.757 1.00 27.88 ? 74 ASP A CG 1 ATOM 572 O OD1 . ASP A 1 74 ? 42.645 22.251 2.226 1.00 31.13 ? 74 ASP A OD1 1 ATOM 573 O OD2 . ASP A 1 74 ? 41.234 20.651 2.082 1.00 30.35 ? 74 ASP A OD2 1 ATOM 574 N N . GLY A 1 75 ? 40.331 20.359 7.233 1.00 27.20 ? 75 GLY A N 1 ATOM 575 C CA . GLY A 1 75 ? 40.330 19.692 8.521 1.00 27.56 ? 75 GLY A CA 1 ATOM 576 C C . GLY A 1 75 ? 40.971 20.389 9.709 1.00 27.68 ? 75 GLY A C 1 ATOM 577 O O . GLY A 1 75 ? 41.103 19.787 10.774 1.00 28.14 ? 75 GLY A O 1 ATOM 578 N N . ALA A 1 76 ? 41.397 21.634 9.570 1.00 27.00 ? 76 ALA A N 1 ATOM 579 C CA . ALA A 1 76 ? 41.872 22.299 10.775 1.00 27.35 ? 76 ALA A CA 1 ATOM 580 C C . ALA A 1 76 ? 40.668 22.757 11.620 1.00 27.44 ? 76 ALA A C 1 ATOM 581 O O . ALA A 1 76 ? 40.797 23.216 12.752 1.00 28.68 ? 76 ALA A O 1 ATOM 582 C CB . ALA A 1 76 ? 42.738 23.491 10.428 1.00 27.09 ? 76 ALA A CB 1 ATOM 583 N N . THR A 1 77 ? 39.481 22.641 11.090 1.00 26.83 ? 77 THR A N 1 ATOM 584 C CA . THR A 1 77 ? 38.359 23.212 11.808 1.00 26.66 ? 77 THR A CA 1 ATOM 585 C C . THR A 1 77 ? 37.115 22.670 11.181 1.00 24.63 ? 77 THR A C 1 ATOM 586 O O . THR A 1 77 ? 37.057 22.595 9.962 1.00 23.66 ? 77 THR A O 1 ATOM 587 C CB . THR A 1 77 ? 38.435 24.770 11.649 1.00 27.45 ? 77 THR A CB 1 ATOM 588 O OG1 . THR A 1 77 ? 38.786 25.337 12.907 1.00 29.87 ? 77 THR A OG1 1 ATOM 589 C CG2 . THR A 1 77 ? 37.106 25.395 11.347 1.00 27.85 ? 77 THR A CG2 1 ATOM 590 N N . TRP A 1 78 ? 36.135 22.330 12.020 1.00 23.42 ? 78 TRP A N 1 ATOM 591 C CA . TRP A 1 78 ? 34.881 21.731 11.584 1.00 22.28 ? 78 TRP A CA 1 ATOM 592 C C . TRP A 1 78 ? 33.671 22.330 12.310 1.00 22.41 ? 78 TRP A C 1 ATOM 593 O O . TRP A 1 78 ? 33.761 22.646 13.486 1.00 21.43 ? 78 TRP A O 1 ATOM 594 C CB . TRP A 1 78 ? 34.883 20.225 11.909 1.00 21.68 ? 78 TRP A CB 1 ATOM 595 C CG . TRP A 1 78 ? 35.967 19.433 11.299 1.00 19.37 ? 78 TRP A CG 1 ATOM 596 C CD1 . TRP A 1 78 ? 37.210 19.230 11.799 1.00 16.27 ? 78 TRP A CD1 1 ATOM 597 C CD2 . TRP A 1 78 ? 35.905 18.710 10.069 1.00 17.24 ? 78 TRP A CD2 1 ATOM 598 N NE1 . TRP A 1 78 ? 37.933 18.446 10.942 1.00 14.33 ? 78 TRP A NE1 1 ATOM 599 C CE2 . TRP A 1 78 ? 37.146 18.105 9.878 1.00 15.70 ? 78 TRP A CE2 1 ATOM 600 C CE3 . TRP A 1 78 ? 34.907 18.499 9.117 1.00 16.25 ? 78 TRP A CE3 1 ATOM 601 C CZ2 . TRP A 1 78 ? 37.428 17.319 8.774 1.00 17.08 ? 78 TRP A CZ2 1 ATOM 602 C CZ3 . TRP A 1 78 ? 35.180 17.733 8.031 1.00 16.81 ? 78 TRP A CZ3 1 ATOM 603 C CH2 . TRP A 1 78 ? 36.435 17.142 7.863 1.00 17.13 ? 78 TRP A CH2 1 ATOM 604 N N . ASN A 1 79 ? 32.546 22.469 11.601 1.00 22.39 ? 79 ASN A N 1 ATOM 605 C CA . ASN A 1 79 ? 31.274 22.799 12.224 1.00 23.00 ? 79 ASN A CA 1 ATOM 606 C C . ASN A 1 79 ? 30.431 21.501 12.211 1.00 22.73 ? 79 ASN A C 1 ATOM 607 O O . ASN A 1 79 ? 30.605 20.664 11.309 1.00 22.10 ? 79 ASN A O 1 ATOM 608 C CB . ASN A 1 79 ? 30.553 23.874 11.423 1.00 23.86 ? 79 ASN A CB 1 ATOM 609 C CG . ASN A 1 79 ? 31.207 25.263 11.550 1.00 27.50 ? 79 ASN A CG 1 ATOM 610 O OD1 . ASN A 1 79 ? 32.039 25.516 12.432 1.00 30.29 ? 79 ASN A OD1 1 ATOM 611 N ND2 . ASN A 1 79 ? 30.822 26.163 10.660 1.00 27.81 ? 79 ASN A ND2 1 ATOM 612 N N . THR A 1 80 ? 29.473 21.391 13.134 1.00 21.19 ? 80 THR A N 1 ATOM 613 C CA . THR A 1 80 ? 28.682 20.186 13.335 1.00 20.06 ? 80 THR A CA 1 ATOM 614 C C . THR A 1 80 ? 27.181 20.456 13.238 1.00 20.96 ? 80 THR A C 1 ATOM 615 O O . THR A 1 80 ? 26.682 21.460 13.765 1.00 20.80 ? 80 THR A O 1 ATOM 616 C CB . THR A 1 80 ? 29.053 19.617 14.728 1.00 19.48 ? 80 THR A CB 1 ATOM 617 O OG1 . THR A 1 80 ? 30.444 19.302 14.737 1.00 18.43 ? 80 THR A OG1 1 ATOM 618 C CG2 . THR A 1 80 ? 28.438 18.286 14.969 1.00 18.69 ? 80 THR A CG2 1 ATOM 619 N N . GLN A 1 81 ? 26.465 19.576 12.541 1.00 20.89 ? 81 GLN A N 1 ATOM 620 C CA . GLN A 1 81 ? 25.020 19.686 12.404 1.00 21.24 ? 81 GLN A CA 1 ATOM 621 C C . GLN A 1 81 ? 24.417 18.317 12.461 1.00 21.24 ? 81 GLN A C 1 ATOM 622 O O . GLN A 1 81 ? 25.126 17.303 12.381 1.00 21.69 ? 81 GLN A O 1 ATOM 623 C CB . GLN A 1 81 ? 24.611 20.220 11.032 1.00 21.88 ? 81 GLN A CB 1 ATOM 624 C CG . GLN A 1 81 ? 25.290 21.488 10.566 1.00 23.83 ? 81 GLN A CG 1 ATOM 625 C CD . GLN A 1 81 ? 25.099 21.683 9.088 1.00 23.95 ? 81 GLN A CD 1 ATOM 626 O OE1 . GLN A 1 81 ? 25.453 20.811 8.277 1.00 24.10 ? 81 GLN A OE1 1 ATOM 627 N NE2 . GLN A 1 81 ? 24.525 22.808 8.724 1.00 23.32 ? 81 GLN A NE2 1 ATOM 628 N N . ILE A 1 82 ? 23.101 18.306 12.601 1.00 20.25 ? 82 ILE A N 1 ATOM 629 C CA . ILE A 1 82 ? 22.293 17.132 12.405 1.00 19.95 ? 82 ILE A CA 1 ATOM 630 C C . ILE A 1 82 ? 21.568 17.441 11.113 1.00 21.28 ? 82 ILE A C 1 ATOM 631 O O . ILE A 1 82 ? 20.712 18.309 11.084 1.00 22.40 ? 82 ILE A O 1 ATOM 632 C CB . ILE A 1 82 ? 21.263 16.991 13.522 1.00 19.95 ? 82 ILE A CB 1 ATOM 633 C CG1 . ILE A 1 82 ? 21.920 16.431 14.785 1.00 16.90 ? 82 ILE A CG1 1 ATOM 634 C CG2 . ILE A 1 82 ? 20.101 16.109 13.056 1.00 17.39 ? 82 ILE A CG2 1 ATOM 635 C CD1 . ILE A 1 82 ? 22.859 15.233 14.525 1.00 15.53 ? 82 ILE A CD1 1 ATOM 636 N N . ALA A 1 83 ? 21.925 16.752 10.037 1.00 21.76 ? 83 ALA A N 1 ATOM 637 C CA . ALA A 1 83 ? 21.383 17.030 8.716 1.00 21.31 ? 83 ALA A CA 1 ATOM 638 C C . ALA A 1 83 ? 20.026 16.415 8.440 1.00 21.13 ? 83 ALA A C 1 ATOM 639 O O . ALA A 1 83 ? 19.295 16.914 7.600 1.00 21.86 ? 83 ALA A O 1 ATOM 640 C CB . ALA A 1 83 ? 22.343 16.576 7.686 1.00 21.24 ? 83 ALA A CB 1 ATOM 641 N N . ILE A 1 84 ? 19.704 15.313 9.109 1.00 20.80 ? 84 ILE A N 1 ATOM 642 C CA . ILE A 1 84 ? 18.422 14.653 8.920 1.00 20.47 ? 84 ILE A CA 1 ATOM 643 C C . ILE A 1 84 ? 17.999 14.111 10.265 1.00 21.07 ? 84 ILE A C 1 ATOM 644 O O . ILE A 1 84 ? 18.726 13.313 10.856 1.00 20.92 ? 84 ILE A O 1 ATOM 645 C CB . ILE A 1 84 ? 18.502 13.463 7.924 1.00 20.14 ? 84 ILE A CB 1 ATOM 646 C CG1 . ILE A 1 84 ? 19.292 13.838 6.672 1.00 19.07 ? 84 ILE A CG1 1 ATOM 647 C CG2 . ILE A 1 84 ? 17.066 12.970 7.586 1.00 18.19 ? 84 ILE A CG2 1 ATOM 648 C CD1 . ILE A 1 84 ? 19.583 12.671 5.809 1.00 18.88 ? 84 ILE A CD1 1 ATOM 649 N N . LYS A 1 85 ? 16.824 14.549 10.715 1.00 21.21 ? 85 LYS A N 1 ATOM 650 C CA . LYS A 1 85 ? 16.227 14.163 11.983 1.00 21.45 ? 85 LYS A CA 1 ATOM 651 C C . LYS A 1 85 ? 15.459 12.911 11.708 1.00 20.96 ? 85 LYS A C 1 ATOM 652 O O . LYS A 1 85 ? 15.031 12.700 10.584 1.00 21.20 ? 85 LYS A O 1 ATOM 653 C CB . LYS A 1 85 ? 15.190 15.212 12.422 1.00 21.60 ? 85 LYS A CB 1 ATOM 654 C CG . LYS A 1 85 ? 15.750 16.552 12.890 1.00 24.84 ? 85 LYS A CG 1 ATOM 655 C CD . LYS A 1 85 ? 14.774 17.727 12.548 1.00 31.36 ? 85 LYS A CD 1 ATOM 656 C CE . LYS A 1 85 ? 13.389 17.622 13.246 1.00 33.89 ? 85 LYS A CE 1 ATOM 657 N NZ . LYS A 1 85 ? 12.234 18.178 12.446 1.00 34.78 ? 85 LYS A NZ 1 ATOM 658 N N . ASN A 1 86 ? 15.260 12.080 12.712 1.00 20.67 ? 86 ASN A N 1 ATOM 659 C CA . ASN A 1 86 ? 14.424 10.923 12.470 1.00 21.85 ? 86 ASN A CA 1 ATOM 660 C C . ASN A 1 86 ? 12.976 11.326 12.815 1.00 22.17 ? 86 ASN A C 1 ATOM 661 O O . ASN A 1 86 ? 12.747 12.428 13.279 1.00 22.35 ? 86 ASN A O 1 ATOM 662 C CB . ASN A 1 86 ? 14.902 9.695 13.263 1.00 20.45 ? 86 ASN A CB 1 ATOM 663 C CG . ASN A 1 86 ? 14.877 9.925 14.766 1.00 21.63 ? 86 ASN A CG 1 ATOM 664 O OD1 . ASN A 1 86 ? 15.804 9.533 15.490 1.00 21.01 ? 86 ASN A OD1 1 ATOM 665 N ND2 . ASN A 1 86 ? 13.797 10.533 15.252 1.00 17.19 ? 86 ASN A ND2 1 ATOM 666 N N . SER A 1 87 ? 12.029 10.419 12.624 1.00 22.99 ? 87 SER A N 1 ATOM 667 C CA . SER A 1 87 ? 10.616 10.691 12.839 1.00 23.76 ? 87 SER A CA 1 ATOM 668 C C . SER A 1 87 ? 10.155 10.902 14.269 1.00 24.60 ? 87 SER A C 1 ATOM 669 O O . SER A 1 87 ? 9.031 11.354 14.482 1.00 25.46 ? 87 SER A O 1 ATOM 670 C CB . SER A 1 87 ? 9.812 9.514 12.333 1.00 23.90 ? 87 SER A CB 1 ATOM 671 O OG . SER A 1 87 ? 9.906 8.469 13.284 1.00 24.87 ? 87 SER A OG 1 ATOM 672 N N . ARG A 1 88 ? 10.955 10.493 15.242 1.00 25.15 ? 88 ARG A N 1 ATOM 673 C CA . ARG A 1 88 ? 10.606 10.656 16.647 1.00 25.70 ? 88 ARG A CA 1 ATOM 674 C C . ARG A 1 88 ? 9.354 9.841 17.016 1.00 26.27 ? 88 ARG A C 1 ATOM 675 O O . ARG A 1 88 ? 8.637 10.154 17.955 1.00 25.97 ? 88 ARG A O 1 ATOM 676 C CB . ARG A 1 88 ? 10.392 12.137 16.958 1.00 25.91 ? 88 ARG A CB 1 ATOM 677 C CG . ARG A 1 88 ? 11.566 13.032 16.609 1.00 25.09 ? 88 ARG A CG 1 ATOM 678 C CD . ARG A 1 88 ? 12.860 12.713 17.359 1.00 26.24 ? 88 ARG A CD 1 ATOM 679 N NE . ARG A 1 88 ? 13.978 13.443 16.766 1.00 26.72 ? 88 ARG A NE 1 ATOM 680 C CZ . ARG A 1 88 ? 14.363 14.635 17.168 1.00 27.46 ? 88 ARG A CZ 1 ATOM 681 N NH1 . ARG A 1 88 ? 15.381 15.255 16.571 1.00 27.12 ? 88 ARG A NH1 1 ATOM 682 N NH2 . ARG A 1 88 ? 13.737 15.209 18.194 1.00 27.99 ? 88 ARG A NH2 1 ATOM 683 N N . ALA A 1 89 ? 9.092 8.785 16.266 1.00 26.64 ? 89 ALA A N 1 ATOM 684 C CA . ALA A 1 89 ? 7.890 8.029 16.505 1.00 26.82 ? 89 ALA A CA 1 ATOM 685 C C . ALA A 1 89 ? 8.003 7.086 17.701 1.00 27.29 ? 89 ALA A C 1 ATOM 686 O O . ALA A 1 89 ? 7.016 6.848 18.368 1.00 27.93 ? 89 ALA A O 1 ATOM 687 C CB . ALA A 1 89 ? 7.505 7.291 15.280 1.00 26.08 ? 89 ALA A CB 1 ATOM 688 N N . SER A 1 90 ? 9.184 6.521 17.944 1.00 27.44 ? 90 SER A N 1 ATOM 689 C CA . SER A 1 90 ? 9.415 5.663 19.118 1.00 26.82 ? 90 SER A CA 1 ATOM 690 C C . SER A 1 90 ? 10.846 5.838 19.522 1.00 26.46 ? 90 SER A C 1 ATOM 691 O O . SER A 1 90 ? 11.589 6.593 18.890 1.00 26.44 ? 90 SER A O 1 ATOM 692 C CB . SER A 1 90 ? 9.224 4.193 18.792 1.00 26.66 ? 90 SER A CB 1 ATOM 693 O OG . SER A 1 90 ? 10.440 3.648 18.289 1.00 27.51 ? 90 SER A OG 1 ATOM 694 N N . SER A 1 91 ? 11.257 5.073 20.522 1.00 26.25 ? 91 SER A N 1 ATOM 695 C CA . SER A 1 91 ? 12.620 5.127 21.012 1.00 25.78 ? 91 SER A CA 1 ATOM 696 C C . SER A 1 91 ? 13.630 4.505 20.060 1.00 24.84 ? 91 SER A C 1 ATOM 697 O O . SER A 1 91 ? 14.845 4.572 20.319 1.00 25.54 ? 91 SER A O 1 ATOM 698 C CB . SER A 1 91 ? 12.722 4.435 22.378 1.00 26.66 ? 91 SER A CB 1 ATOM 699 O OG . SER A 1 91 ? 12.502 3.038 22.252 1.00 29.12 ? 91 SER A OG 1 ATOM 700 N N . VAL A 1 92 ? 13.163 3.879 18.984 1.00 23.00 ? 92 VAL A N 1 ATOM 701 C CA . VAL A 1 92 ? 14.091 3.299 18.014 1.00 22.02 ? 92 VAL A CA 1 ATOM 702 C C . VAL A 1 92 ? 13.971 3.939 16.615 1.00 21.82 ? 92 VAL A C 1 ATOM 703 O O . VAL A 1 92 ? 14.540 3.443 15.646 1.00 21.01 ? 92 VAL A O 1 ATOM 704 C CB . VAL A 1 92 ? 13.959 1.756 17.895 1.00 22.05 ? 92 VAL A CB 1 ATOM 705 C CG1 . VAL A 1 92 ? 14.320 1.092 19.212 1.00 21.05 ? 92 VAL A CG1 1 ATOM 706 C CG2 . VAL A 1 92 ? 12.551 1.354 17.420 1.00 19.45 ? 92 VAL A CG2 1 ATOM 707 N N . SER A 1 93 ? 13.227 5.029 16.511 1.00 20.89 ? 93 SER A N 1 ATOM 708 C CA . SER A 1 93 ? 13.080 5.660 15.218 1.00 20.78 ? 93 SER A CA 1 ATOM 709 C C . SER A 1 93 ? 14.487 6.064 14.763 1.00 19.81 ? 93 SER A C 1 ATOM 710 O O . SER A 1 93 ? 15.292 6.562 15.554 1.00 20.26 ? 93 SER A O 1 ATOM 711 C CB . SER A 1 93 ? 12.183 6.891 15.311 1.00 20.83 ? 93 SER A CB 1 ATOM 712 O OG . SER A 1 93 ? 10.886 6.536 15.786 1.00 23.04 ? 93 SER A OG 1 ATOM 713 N N . ARG A 1 94 ? 14.775 5.837 13.495 1.00 17.73 ? 94 ARG A N 1 ATOM 714 C CA . ARG A 1 94 ? 16.097 6.101 12.999 1.00 16.23 ? 94 ARG A CA 1 ATOM 715 C C . ARG A 1 94 ? 16.078 6.473 11.537 1.00 15.20 ? 94 ARG A C 1 ATOM 716 O O . ARG A 1 94 ? 15.232 6.006 10.784 1.00 14.74 ? 94 ARG A O 1 ATOM 717 C CB . ARG A 1 94 ? 16.955 4.841 13.203 1.00 15.68 ? 94 ARG A CB 1 ATOM 718 C CG . ARG A 1 94 ? 16.270 3.588 12.748 1.00 13.45 ? 94 ARG A CG 1 ATOM 719 C CD . ARG A 1 94 ? 16.830 2.304 13.309 1.00 14.15 ? 94 ARG A CD 1 ATOM 720 N NE . ARG A 1 94 ? 16.248 1.108 12.686 1.00 12.67 ? 94 ARG A NE 1 ATOM 721 C CZ . ARG A 1 94 ? 15.123 0.521 13.079 1.00 13.25 ? 94 ARG A CZ 1 ATOM 722 N NH1 . ARG A 1 94 ? 14.425 1.054 14.077 1.00 14.78 ? 94 ARG A NH1 1 ATOM 723 N NH2 . ARG A 1 94 ? 14.663 -0.586 12.466 1.00 11.85 ? 94 ARG A NH2 1 ATOM 724 N N . VAL A 1 95 ? 17.003 7.350 11.171 1.00 15.29 ? 95 VAL A N 1 ATOM 725 C CA . VAL A 1 95 ? 17.344 7.639 9.776 1.00 15.56 ? 95 VAL A CA 1 ATOM 726 C C . VAL A 1 95 ? 18.827 7.215 9.736 1.00 15.34 ? 95 VAL A C 1 ATOM 727 O O . VAL A 1 95 ? 19.593 7.552 10.654 1.00 15.32 ? 95 VAL A O 1 ATOM 728 C CB . VAL A 1 95 ? 17.105 9.109 9.379 1.00 15.67 ? 95 VAL A CB 1 ATOM 729 C CG1 . VAL A 1 95 ? 15.618 9.384 9.277 1.00 16.56 ? 95 VAL A CG1 1 ATOM 730 C CG2 . VAL A 1 95 ? 17.746 10.101 10.373 1.00 15.11 ? 95 VAL A CG2 1 ATOM 731 N N . MET A 1 96 ? 19.223 6.454 8.713 1.00 14.39 ? 96 MET A N 1 ATOM 732 C CA . MET A 1 96 ? 20.504 5.757 8.783 1.00 13.45 ? 96 MET A CA 1 ATOM 733 C C . MET A 1 96 ? 21.028 5.245 7.437 1.00 12.65 ? 96 MET A C 1 ATOM 734 O O . MET A 1 96 ? 20.287 5.163 6.443 1.00 11.18 ? 96 MET A O 1 ATOM 735 C CB . MET A 1 96 ? 20.362 4.553 9.728 1.00 13.49 ? 96 MET A CB 1 ATOM 736 C CG . MET A 1 96 ? 19.456 3.409 9.153 1.00 14.91 ? 96 MET A CG 1 ATOM 737 S SD . MET A 1 96 ? 18.890 2.100 10.366 1.00 16.84 ? 96 MET A SD 1 ATOM 738 C CE . MET A 1 96 ? 20.544 1.479 10.917 1.00 15.87 ? 96 MET A CE 1 ATOM 739 N N . ASP A 1 97 ? 22.324 4.913 7.430 1.00 11.95 ? 97 ASP A N 1 ATOM 740 C CA . ASP A 1 97 ? 22.991 4.326 6.255 1.00 12.80 ? 97 ASP A CA 1 ATOM 741 C C . ASP A 1 97 ? 23.044 5.260 5.058 1.00 12.82 ? 97 ASP A C 1 ATOM 742 O O . ASP A 1 97 ? 22.607 4.912 3.967 1.00 13.31 ? 97 ASP A O 1 ATOM 743 C CB . ASP A 1 97 ? 22.311 3.014 5.850 1.00 12.39 ? 97 ASP A CB 1 ATOM 744 C CG . ASP A 1 97 ? 22.354 1.975 6.958 1.00 15.55 ? 97 ASP A CG 1 ATOM 745 O OD1 . ASP A 1 97 ? 23.427 1.837 7.609 1.00 15.94 ? 97 ASP A OD1 1 ATOM 746 O OD2 . ASP A 1 97 ? 21.357 1.287 7.294 1.00 15.56 ? 97 ASP A OD2 1 ATOM 747 N N . ALA A 1 98 ? 23.584 6.448 5.260 1.00 12.54 ? 98 ALA A N 1 ATOM 748 C CA . ALA A 1 98 ? 23.645 7.430 4.195 1.00 12.44 ? 98 ALA A CA 1 ATOM 749 C C . ALA A 1 98 ? 24.406 7.008 2.925 1.00 12.70 ? 98 ALA A C 1 ATOM 750 O O . ALA A 1 98 ? 25.506 6.485 2.995 1.00 12.32 ? 98 ALA A O 1 ATOM 751 C CB . ALA A 1 98 ? 24.246 8.674 4.741 1.00 11.48 ? 98 ALA A CB 1 ATOM 752 N N . THR A 1 99 ? 23.806 7.280 1.776 1.00 13.15 ? 99 THR A N 1 ATOM 753 C CA . THR A 1 99 ? 24.452 7.123 0.480 1.00 14.02 ? 99 THR A CA 1 ATOM 754 C C . THR A 1 99 ? 24.407 8.529 -0.080 1.00 14.34 ? 99 THR A C 1 ATOM 755 O O . THR A 1 99 ? 23.382 9.210 0.043 1.00 15.50 ? 99 THR A O 1 ATOM 756 C CB . THR A 1 99 ? 23.717 6.146 -0.414 1.00 14.65 ? 99 THR A CB 1 ATOM 757 O OG1 . THR A 1 99 ? 23.506 4.916 0.295 1.00 15.84 ? 99 THR A OG1 1 ATOM 758 C CG2 . THR A 1 99 ? 24.646 5.734 -1.578 1.00 11.60 ? 99 THR A CG2 1 ATOM 759 N N . VAL A 1 100 ? 25.497 8.965 -0.689 1.00 13.46 ? 100 VAL A N 1 ATOM 760 C CA . VAL A 1 100 ? 25.666 10.371 -0.961 1.00 13.14 ? 100 VAL A CA 1 ATOM 761 C C . VAL A 1 100 ? 26.179 10.622 -2.354 1.00 13.68 ? 100 VAL A C 1 ATOM 762 O O . VAL A 1 100 ? 27.096 9.945 -2.814 1.00 14.33 ? 100 VAL A O 1 ATOM 763 C CB . VAL A 1 100 ? 26.768 10.915 0.034 1.00 13.79 ? 100 VAL A CB 1 ATOM 764 C CG1 . VAL A 1 100 ? 27.073 12.388 -0.191 1.00 11.84 ? 100 VAL A CG1 1 ATOM 765 C CG2 . VAL A 1 100 ? 26.292 10.687 1.467 1.00 13.91 ? 100 VAL A CG2 1 ATOM 766 N N . ILE A 1 101 ? 25.597 11.600 -3.027 1.00 14.26 ? 101 ILE A N 1 ATOM 767 C CA . ILE A 1 101 ? 26.089 12.025 -4.329 1.00 14.41 ? 101 ILE A CA 1 ATOM 768 C C . ILE A 1 101 ? 26.341 13.531 -4.276 1.00 14.92 ? 101 ILE A C 1 ATOM 769 O O . ILE A 1 101 ? 25.518 14.267 -3.737 1.00 14.65 ? 101 ILE A O 1 ATOM 770 C CB . ILE A 1 101 ? 25.049 11.771 -5.431 1.00 14.65 ? 101 ILE A CB 1 ATOM 771 C CG1 . ILE A 1 101 ? 24.730 10.285 -5.576 1.00 14.45 ? 101 ILE A CG1 1 ATOM 772 C CG2 . ILE A 1 101 ? 25.527 12.396 -6.743 1.00 14.15 ? 101 ILE A CG2 1 ATOM 773 C CD1 . ILE A 1 101 ? 23.519 10.021 -6.545 1.00 14.11 ? 101 ILE A CD1 1 ATOM 774 N N . VAL A 1 102 ? 27.470 13.982 -4.820 1.00 14.87 ? 102 VAL A N 1 ATOM 775 C CA . VAL A 1 102 ? 27.771 15.397 -4.880 1.00 15.96 ? 102 VAL A CA 1 ATOM 776 C C . VAL A 1 102 ? 27.610 15.885 -6.316 1.00 16.50 ? 102 VAL A C 1 ATOM 777 O O . VAL A 1 102 ? 28.154 15.292 -7.240 1.00 15.98 ? 102 VAL A O 1 ATOM 778 C CB . VAL A 1 102 ? 29.233 15.689 -4.443 1.00 16.63 ? 102 VAL A CB 1 ATOM 779 C CG1 . VAL A 1 102 ? 29.643 17.123 -4.798 1.00 16.58 ? 102 VAL A CG1 1 ATOM 780 C CG2 . VAL A 1 102 ? 29.411 15.426 -2.936 1.00 15.74 ? 102 VAL A CG2 1 ATOM 781 N N . LYS A 1 103 ? 26.800 16.917 -6.517 1.00 17.33 ? 103 LYS A N 1 ATOM 782 C CA . LYS A 1 103 ? 26.753 17.561 -7.840 1.00 18.40 ? 103 LYS A CA 1 ATOM 783 C C . LYS A 1 103 ? 26.717 19.062 -7.705 1.00 18.61 ? 103 LYS A C 1 ATOM 784 O O . LYS A 1 103 ? 25.772 19.609 -7.138 1.00 19.42 ? 103 LYS A O 1 ATOM 785 C CB . LYS A 1 103 ? 25.601 17.079 -8.734 1.00 18.39 ? 103 LYS A CB 1 ATOM 786 C CG . LYS A 1 103 ? 25.825 17.444 -10.225 1.00 16.81 ? 103 LYS A CG 1 ATOM 787 C CD . LYS A 1 103 ? 24.627 17.080 -11.127 1.00 15.58 ? 103 LYS A CD 1 ATOM 788 C CE . LYS A 1 103 ? 24.875 17.316 -12.652 1.00 11.53 ? 103 LYS A CE 1 ATOM 789 N NZ . LYS A 1 103 ? 23.627 16.927 -13.470 1.00 8.92 ? 103 LYS A NZ 1 ATOM 790 N N . GLY A 1 104 ? 27.741 19.721 -8.249 1.00 19.38 ? 104 GLY A N 1 ATOM 791 C CA . GLY A 1 104 ? 27.891 21.168 -8.156 1.00 18.63 ? 104 GLY A CA 1 ATOM 792 C C . GLY A 1 104 ? 28.028 21.495 -6.685 1.00 19.12 ? 104 GLY A C 1 ATOM 793 O O . GLY A 1 104 ? 28.840 20.875 -5.971 1.00 18.79 ? 104 GLY A O 1 ATOM 794 N N . ASN A 1 105 ? 27.235 22.447 -6.204 1.00 19.20 ? 105 ASN A N 1 ATOM 795 C CA . ASN A 1 105 ? 27.281 22.778 -4.790 1.00 19.90 ? 105 ASN A CA 1 ATOM 796 C C . ASN A 1 105 ? 26.184 22.017 -4.025 1.00 19.06 ? 105 ASN A C 1 ATOM 797 O O . ASN A 1 105 ? 25.820 22.372 -2.901 1.00 18.34 ? 105 ASN A O 1 ATOM 798 C CB . ASN A 1 105 ? 27.202 24.290 -4.572 1.00 20.53 ? 105 ASN A CB 1 ATOM 799 C CG . ASN A 1 105 ? 25.778 24.812 -4.628 1.00 24.40 ? 105 ASN A CG 1 ATOM 800 O OD1 . ASN A 1 105 ? 24.945 24.281 -5.354 1.00 27.31 ? 105 ASN A OD1 1 ATOM 801 N ND2 . ASN A 1 105 ? 25.495 25.881 -3.865 1.00 29.15 ? 105 ASN A ND2 1 ATOM 802 N N . LYS A 1 106 ? 25.686 20.935 -4.615 1.00 18.61 ? 106 LYS A N 1 ATOM 803 C CA . LYS A 1 106 ? 24.641 20.199 -3.912 1.00 19.60 ? 106 LYS A CA 1 ATOM 804 C C . LYS A 1 106 ? 24.995 18.791 -3.500 1.00 18.86 ? 106 LYS A C 1 ATOM 805 O O . LYS A 1 106 ? 25.728 18.100 -4.193 1.00 18.07 ? 106 LYS A O 1 ATOM 806 C CB . LYS A 1 106 ? 23.355 20.168 -4.746 1.00 20.08 ? 106 LYS A CB 1 ATOM 807 C CG . LYS A 1 106 ? 22.865 21.567 -5.101 1.00 22.68 ? 106 LYS A CG 1 ATOM 808 C CD . LYS A 1 106 ? 21.382 21.601 -5.374 1.00 26.19 ? 106 LYS A CD 1 ATOM 809 C CE . LYS A 1 106 ? 20.918 23.043 -5.588 1.00 30.28 ? 106 LYS A CE 1 ATOM 810 N NZ . LYS A 1 106 ? 19.460 23.083 -5.888 1.00 32.22 ? 106 LYS A NZ 1 ATOM 811 N N . LEU A 1 107 ? 24.423 18.376 -2.373 1.00 19.30 ? 107 LEU A N 1 ATOM 812 C CA . LEU A 1 107 ? 24.547 17.006 -1.886 1.00 19.07 ? 107 LEU A CA 1 ATOM 813 C C . LEU A 1 107 ? 23.194 16.321 -1.860 1.00 18.77 ? 107 LEU A C 1 ATOM 814 O O . LEU A 1 107 ? 22.215 16.850 -1.324 1.00 19.27 ? 107 LEU A O 1 ATOM 815 C CB . LEU A 1 107 ? 25.089 16.968 -0.470 1.00 19.86 ? 107 LEU A CB 1 ATOM 816 C CG . LEU A 1 107 ? 26.398 17.649 -0.151 1.00 21.20 ? 107 LEU A CG 1 ATOM 817 C CD1 . LEU A 1 107 ? 26.223 18.905 0.684 1.00 21.96 ? 107 LEU A CD1 1 ATOM 818 C CD2 . LEU A 1 107 ? 27.335 16.672 0.578 1.00 22.86 ? 107 LEU A CD2 1 ATOM 819 N N . TYR A 1 108 ? 23.143 15.131 -2.431 1.00 17.26 ? 108 TYR A N 1 ATOM 820 C CA . TYR A 1 108 ? 21.956 14.325 -2.386 1.00 16.23 ? 108 TYR A CA 1 ATOM 821 C C . TYR A 1 108 ? 22.245 13.163 -1.449 1.00 16.42 ? 108 TYR A C 1 ATOM 822 O O . TYR A 1 108 ? 23.134 12.351 -1.707 1.00 16.86 ? 108 TYR A O 1 ATOM 823 C CB . TYR A 1 108 ? 21.630 13.830 -3.770 1.00 16.00 ? 108 TYR A CB 1 ATOM 824 C CG . TYR A 1 108 ? 21.333 14.980 -4.721 1.00 17.39 ? 108 TYR A CG 1 ATOM 825 C CD1 . TYR A 1 108 ? 20.029 15.354 -5.006 1.00 16.82 ? 108 TYR A CD1 1 ATOM 826 C CD2 . TYR A 1 108 ? 22.359 15.672 -5.321 1.00 15.34 ? 108 TYR A CD2 1 ATOM 827 C CE1 . TYR A 1 108 ? 19.762 16.388 -5.849 1.00 17.46 ? 108 TYR A CE1 1 ATOM 828 C CE2 . TYR A 1 108 ? 22.120 16.698 -6.146 1.00 17.58 ? 108 TYR A CE2 1 ATOM 829 C CZ . TYR A 1 108 ? 20.816 17.062 -6.418 1.00 19.18 ? 108 TYR A CZ 1 ATOM 830 O OH . TYR A 1 108 ? 20.597 18.117 -7.276 1.00 20.12 ? 108 TYR A OH 1 ATOM 831 N N . ILE A 1 109 ? 21.505 13.105 -0.355 1.00 15.81 ? 109 ILE A N 1 ATOM 832 C CA . ILE A 1 109 ? 21.656 12.051 0.632 1.00 15.69 ? 109 ILE A CA 1 ATOM 833 C C . ILE A 1 109 ? 20.421 11.171 0.691 1.00 16.29 ? 109 ILE A C 1 ATOM 834 O O . ILE A 1 109 ? 19.293 11.642 0.950 1.00 16.41 ? 109 ILE A O 1 ATOM 835 C CB . ILE A 1 109 ? 21.906 12.624 2.041 1.00 15.81 ? 109 ILE A CB 1 ATOM 836 C CG1 . ILE A 1 109 ? 23.167 13.484 2.111 1.00 16.30 ? 109 ILE A CG1 1 ATOM 837 C CG2 . ILE A 1 109 ? 22.038 11.507 3.056 1.00 13.30 ? 109 ILE A CG2 1 ATOM 838 C CD1 . ILE A 1 109 ? 23.644 13.746 3.587 1.00 16.03 ? 109 ILE A CD1 1 ATOM 839 N N . LEU A 1 110 ? 20.620 9.886 0.447 1.00 15.48 ? 110 LEU A N 1 ATOM 840 C CA . LEU A 1 110 ? 19.555 8.910 0.543 1.00 15.10 ? 110 LEU A CA 1 ATOM 841 C C . LEU A 1 110 ? 19.793 8.085 1.823 1.00 15.20 ? 110 LEU A C 1 ATOM 842 O O . LEU A 1 110 ? 20.898 7.609 2.063 1.00 13.80 ? 110 LEU A O 1 ATOM 843 C CB . LEU A 1 110 ? 19.614 8.037 -0.698 1.00 14.86 ? 110 LEU A CB 1 ATOM 844 C CG . LEU A 1 110 ? 18.776 6.784 -0.735 1.00 13.65 ? 110 LEU A CG 1 ATOM 845 C CD1 . LEU A 1 110 ? 17.305 7.216 -0.704 1.00 15.76 ? 110 LEU A CD1 1 ATOM 846 C CD2 . LEU A 1 110 ? 19.054 5.919 -1.955 1.00 10.43 ? 110 LEU A CD2 1 ATOM 847 N N . VAL A 1 111 ? 18.762 7.974 2.657 1.00 15.06 ? 111 VAL A N 1 ATOM 848 C CA . VAL A 1 111 ? 18.869 7.211 3.900 1.00 14.97 ? 111 VAL A CA 1 ATOM 849 C C . VAL A 1 111 ? 17.667 6.315 4.042 1.00 15.13 ? 111 VAL A C 1 ATOM 850 O O . VAL A 1 111 ? 16.627 6.550 3.407 1.00 14.36 ? 111 VAL A O 1 ATOM 851 C CB . VAL A 1 111 ? 18.945 8.125 5.184 1.00 14.47 ? 111 VAL A CB 1 ATOM 852 C CG1 . VAL A 1 111 ? 20.348 8.794 5.348 1.00 13.63 ? 111 VAL A CG1 1 ATOM 853 C CG2 . VAL A 1 111 ? 17.788 9.174 5.200 1.00 14.09 ? 111 VAL A CG2 1 ATOM 854 N N . GLY A 1 112 ? 17.808 5.280 4.876 1.00 15.61 ? 112 GLY A N 1 ATOM 855 C CA . GLY A 1 112 ? 16.677 4.421 5.204 1.00 16.34 ? 112 GLY A CA 1 ATOM 856 C C . GLY A 1 112 ? 16.022 4.993 6.443 1.00 17.46 ? 112 GLY A C 1 ATOM 857 O O . GLY A 1 112 ? 16.720 5.387 7.388 1.00 17.63 ? 112 GLY A O 1 ATOM 858 N N . SER A 1 113 ? 14.695 5.076 6.451 1.00 18.21 ? 113 SER A N 1 ATOM 859 C CA . SER A 1 113 ? 13.999 5.641 7.608 1.00 18.44 ? 113 SER A CA 1 ATOM 860 C C . SER A 1 113 ? 13.043 4.639 8.223 1.00 18.62 ? 113 SER A C 1 ATOM 861 O O . SER A 1 113 ? 12.247 4.050 7.531 1.00 18.87 ? 113 SER A O 1 ATOM 862 C CB . SER A 1 113 ? 13.235 6.926 7.223 1.00 19.33 ? 113 SER A CB 1 ATOM 863 O OG . SER A 1 113 ? 12.636 7.536 8.362 1.00 16.49 ? 113 SER A OG 1 ATOM 864 N N . PHE A 1 114 ? 13.143 4.485 9.537 1.00 19.25 ? 114 PHE A N 1 ATOM 865 C CA . PHE A 1 114 ? 12.369 3.522 10.286 1.00 20.03 ? 114 PHE A CA 1 ATOM 866 C C . PHE A 1 114 ? 11.751 4.152 11.544 1.00 21.01 ? 114 PHE A C 1 ATOM 867 O O . PHE A 1 114 ? 12.369 4.987 12.208 1.00 20.95 ? 114 PHE A O 1 ATOM 868 C CB . PHE A 1 114 ? 13.250 2.326 10.650 1.00 19.14 ? 114 PHE A CB 1 ATOM 869 C CG . PHE A 1 114 ? 13.906 1.694 9.457 1.00 19.27 ? 114 PHE A CG 1 ATOM 870 C CD1 . PHE A 1 114 ? 15.168 2.131 9.022 1.00 16.05 ? 114 PHE A CD1 1 ATOM 871 C CD2 . PHE A 1 114 ? 13.242 0.696 8.727 1.00 17.73 ? 114 PHE A CD2 1 ATOM 872 C CE1 . PHE A 1 114 ? 15.778 1.562 7.899 1.00 15.36 ? 114 PHE A CE1 1 ATOM 873 C CE2 . PHE A 1 114 ? 13.847 0.110 7.610 1.00 18.27 ? 114 PHE A CE2 1 ATOM 874 C CZ . PHE A 1 114 ? 15.127 0.559 7.189 1.00 17.62 ? 114 PHE A CZ 1 ATOM 875 N N . ASN A 1 115 ? 10.530 3.718 11.854 1.00 21.72 ? 115 ASN A N 1 ATOM 876 C CA . ASN A 1 115 ? 9.760 4.256 12.972 1.00 23.31 ? 115 ASN A CA 1 ATOM 877 C C . ASN A 1 115 ? 9.836 3.439 14.263 1.00 23.27 ? 115 ASN A C 1 ATOM 878 O O . ASN A 1 115 ? 10.197 3.967 15.323 1.00 22.44 ? 115 ASN A O 1 ATOM 879 C CB . ASN A 1 115 ? 8.288 4.480 12.540 1.00 23.92 ? 115 ASN A CB 1 ATOM 880 C CG . ASN A 1 115 ? 8.144 5.718 11.694 1.00 26.37 ? 115 ASN A CG 1 ATOM 881 O OD1 . ASN A 1 115 ? 9.077 6.512 11.631 1.00 27.53 ? 115 ASN A OD1 1 ATOM 882 N ND2 . ASN A 1 115 ? 7.004 5.892 11.039 1.00 32.97 ? 115 ASN A ND2 1 ATOM 883 N N . LYS A 1 116 ? 9.543 2.148 14.184 1.00 23.70 ? 116 LYS A N 1 ATOM 884 C CA . LYS A 1 116 ? 9.525 1.392 15.423 1.00 25.21 ? 116 LYS A CA 1 ATOM 885 C C . LYS A 1 116 ? 9.911 -0.080 15.422 1.00 25.23 ? 116 LYS A C 1 ATOM 886 O O . LYS A 1 116 ? 9.790 -0.708 16.471 1.00 25.30 ? 116 LYS A O 1 ATOM 887 C CB . LYS A 1 116 ? 8.171 1.578 16.128 1.00 26.39 ? 116 LYS A CB 1 ATOM 888 C CG . LYS A 1 116 ? 6.962 0.970 15.396 1.00 29.53 ? 116 LYS A CG 1 ATOM 889 C CD . LYS A 1 116 ? 5.584 1.366 16.065 1.00 37.09 ? 116 LYS A CD 1 ATOM 890 C CE . LYS A 1 116 ? 5.103 2.831 15.755 1.00 39.12 ? 116 LYS A CE 1 ATOM 891 N NZ . LYS A 1 116 ? 3.791 3.241 16.431 1.00 42.13 ? 116 LYS A NZ 1 ATOM 892 N N . THR A 1 117 ? 10.375 -0.648 14.300 1.00 24.60 ? 117 THR A N 1 ATOM 893 C CA . THR A 1 117 ? 10.761 -2.070 14.337 1.00 24.34 ? 117 THR A CA 1 ATOM 894 C C . THR A 1 117 ? 12.033 -2.277 15.111 1.00 25.49 ? 117 THR A C 1 ATOM 895 O O . THR A 1 117 ? 12.874 -1.382 15.220 1.00 25.55 ? 117 THR A O 1 ATOM 896 C CB . THR A 1 117 ? 10.938 -2.700 12.959 1.00 24.26 ? 117 THR A CB 1 ATOM 897 O OG1 . THR A 1 117 ? 11.785 -1.878 12.136 1.00 20.51 ? 117 THR A OG1 1 ATOM 898 C CG2 . THR A 1 117 ? 9.585 -2.761 12.223 1.00 23.51 ? 117 THR A CG2 1 ATOM 899 N N . ARG A 1 118 ? 12.200 -3.490 15.597 1.00 26.33 ? 118 ARG A N 1 ATOM 900 C CA . ARG A 1 118 ? 13.315 -3.784 16.445 1.00 27.92 ? 118 ARG A CA 1 ATOM 901 C C . ARG A 1 118 ? 14.141 -4.856 15.815 1.00 27.85 ? 118 ARG A C 1 ATOM 902 O O . ARG A 1 118 ? 15.178 -5.235 16.337 1.00 27.35 ? 118 ARG A O 1 ATOM 903 C CB . ARG A 1 118 ? 12.820 -4.208 17.832 1.00 29.17 ? 118 ARG A CB 1 ATOM 904 C CG . ARG A 1 118 ? 12.069 -3.087 18.546 1.00 32.47 ? 118 ARG A CG 1 ATOM 905 C CD . ARG A 1 118 ? 11.964 -3.261 20.049 1.00 41.22 ? 118 ARG A CD 1 ATOM 906 N NE . ARG A 1 118 ? 11.399 -2.067 20.678 1.00 47.07 ? 118 ARG A NE 1 ATOM 907 C CZ . ARG A 1 118 ? 12.016 -1.337 21.605 1.00 49.22 ? 118 ARG A CZ 1 ATOM 908 N NH1 . ARG A 1 118 ? 13.239 -1.670 22.024 1.00 48.40 ? 118 ARG A NH1 1 ATOM 909 N NH2 . ARG A 1 118 ? 11.406 -0.259 22.103 1.00 50.97 ? 118 ARG A NH2 1 ATOM 910 N N . ASN A 1 119 ? 13.661 -5.383 14.701 1.00 27.99 ? 119 ASN A N 1 ATOM 911 C CA . ASN A 1 119 ? 14.501 -6.297 13.964 1.00 28.42 ? 119 ASN A CA 1 ATOM 912 C C . ASN A 1 119 ? 15.012 -5.648 12.691 1.00 27.54 ? 119 ASN A C 1 ATOM 913 O O . ASN A 1 119 ? 14.612 -4.542 12.345 1.00 26.93 ? 119 ASN A O 1 ATOM 914 C CB . ASN A 1 119 ? 13.799 -7.612 13.673 1.00 29.27 ? 119 ASN A CB 1 ATOM 915 C CG . ASN A 1 119 ? 12.431 -7.428 13.083 1.00 32.71 ? 119 ASN A CG 1 ATOM 916 O OD1 . ASN A 1 119 ? 11.858 -6.326 13.098 1.00 36.20 ? 119 ASN A OD1 1 ATOM 917 N ND2 . ASN A 1 119 ? 11.875 -8.522 12.569 1.00 35.54 ? 119 ASN A ND2 1 ATOM 918 N N . SER A 1 120 ? 15.879 -6.360 11.984 1.00 27.09 ? 120 SER A N 1 ATOM 919 C CA . SER A 1 120 ? 16.516 -5.821 10.803 1.00 26.94 ? 120 SER A CA 1 ATOM 920 C C . SER A 1 120 ? 15.620 -5.825 9.561 1.00 26.70 ? 120 SER A C 1 ATOM 921 O O . SER A 1 120 ? 14.763 -6.719 9.363 1.00 25.58 ? 120 SER A O 1 ATOM 922 C CB . SER A 1 120 ? 17.832 -6.534 10.547 1.00 26.82 ? 120 SER A CB 1 ATOM 923 O OG . SER A 1 120 ? 17.727 -7.407 9.429 1.00 30.36 ? 120 SER A OG 1 ATOM 924 N N . TRP A 1 121 ? 15.865 -4.824 8.723 1.00 26.27 ? 121 TRP A N 1 ATOM 925 C CA . TRP A 1 121 ? 15.048 -4.569 7.539 1.00 26.31 ? 121 TRP A CA 1 ATOM 926 C C . TRP A 1 121 ? 14.762 -5.793 6.677 1.00 26.10 ? 121 TRP A C 1 ATOM 927 O O . TRP A 1 121 ? 13.636 -5.976 6.256 1.00 25.79 ? 121 TRP A O 1 ATOM 928 C CB . TRP A 1 121 ? 15.626 -3.410 6.715 1.00 25.47 ? 121 TRP A CB 1 ATOM 929 C CG . TRP A 1 121 ? 16.839 -3.731 5.919 1.00 25.90 ? 121 TRP A CG 1 ATOM 930 C CD1 . TRP A 1 121 ? 18.049 -4.151 6.387 1.00 27.27 ? 121 TRP A CD1 1 ATOM 931 C CD2 . TRP A 1 121 ? 16.977 -3.622 4.498 1.00 22.75 ? 121 TRP A CD2 1 ATOM 932 N NE1 . TRP A 1 121 ? 18.918 -4.319 5.335 1.00 26.87 ? 121 TRP A NE1 1 ATOM 933 C CE2 . TRP A 1 121 ? 18.279 -3.996 4.168 1.00 22.62 ? 121 TRP A CE2 1 ATOM 934 C CE3 . TRP A 1 121 ? 16.122 -3.226 3.476 1.00 21.80 ? 121 TRP A CE3 1 ATOM 935 C CZ2 . TRP A 1 121 ? 18.749 -3.997 2.858 1.00 21.75 ? 121 TRP A CZ2 1 ATOM 936 C CZ3 . TRP A 1 121 ? 16.575 -3.241 2.177 1.00 21.57 ? 121 TRP A CZ3 1 ATOM 937 C CH2 . TRP A 1 121 ? 17.871 -3.626 1.876 1.00 22.66 ? 121 TRP A CH2 1 ATOM 938 N N . THR A 1 122 ? 15.749 -6.649 6.433 1.00 26.35 ? 122 THR A N 1 ATOM 939 C CA . THR A 1 122 ? 15.484 -7.828 5.589 1.00 26.32 ? 122 THR A CA 1 ATOM 940 C C . THR A 1 122 ? 14.519 -8.770 6.271 1.00 26.37 ? 122 THR A C 1 ATOM 941 O O . THR A 1 122 ? 13.915 -9.630 5.609 1.00 27.23 ? 122 THR A O 1 ATOM 942 C CB . THR A 1 122 ? 16.762 -8.657 5.256 1.00 26.14 ? 122 THR A CB 1 ATOM 943 O OG1 . THR A 1 122 ? 17.446 -8.982 6.476 1.00 27.05 ? 122 THR A OG1 1 ATOM 944 C CG2 . THR A 1 122 ? 17.781 -7.848 4.452 1.00 26.96 ? 122 THR A CG2 1 ATOM 945 N N . GLN A 1 123 ? 14.378 -8.638 7.585 1.00 25.76 ? 123 GLN A N 1 ATOM 946 C CA . GLN A 1 123 ? 13.485 -9.541 8.324 1.00 25.89 ? 123 GLN A CA 1 ATOM 947 C C . GLN A 1 123 ? 12.064 -9.020 8.494 1.00 25.82 ? 123 GLN A C 1 ATOM 948 O O . GLN A 1 123 ? 11.235 -9.720 9.092 1.00 25.95 ? 123 GLN A O 1 ATOM 949 C CB . GLN A 1 123 ? 14.073 -9.878 9.737 1.00 26.76 ? 123 GLN A CB 1 ATOM 950 N N . HIS A 1 124 ? 11.771 -7.811 8.004 1.00 24.22 ? 124 HIS A N 1 ATOM 951 C CA . HIS A 1 124 ? 10.435 -7.257 8.221 1.00 23.69 ? 124 HIS A CA 1 ATOM 952 C C . HIS A 1 124 ? 9.368 -8.060 7.503 1.00 23.55 ? 124 HIS A C 1 ATOM 953 O O . HIS A 1 124 ? 9.621 -8.625 6.437 1.00 23.40 ? 124 HIS A O 1 ATOM 954 C CB . HIS A 1 124 ? 10.337 -5.787 7.772 1.00 23.39 ? 124 HIS A CB 1 ATOM 955 C CG . HIS A 1 124 ? 11.222 -4.863 8.539 1.00 20.51 ? 124 HIS A CG 1 ATOM 956 N ND1 . HIS A 1 124 ? 11.858 -5.241 9.698 1.00 21.30 ? 124 HIS A ND1 1 ATOM 957 C CD2 . HIS A 1 124 ? 11.572 -3.578 8.324 1.00 18.50 ? 124 HIS A CD2 1 ATOM 958 C CE1 . HIS A 1 124 ? 12.553 -4.228 10.176 1.00 17.02 ? 124 HIS A CE1 1 ATOM 959 N NE2 . HIS A 1 124 ? 12.406 -3.210 9.353 1.00 19.14 ? 124 HIS A NE2 1 ATOM 960 N N . ARG A 1 125 ? 8.180 -8.088 8.107 1.00 23.13 ? 125 ARG A N 1 ATOM 961 C CA . ARG A 1 125 ? 7.009 -8.737 7.550 1.00 22.99 ? 125 ARG A CA 1 ATOM 962 C C . ARG A 1 125 ? 6.604 -8.072 6.238 1.00 22.61 ? 125 ARG A C 1 ATOM 963 O O . ARG A 1 125 ? 6.285 -8.752 5.283 1.00 22.51 ? 125 ARG A O 1 ATOM 964 C CB . ARG A 1 125 ? 5.814 -8.700 8.579 1.00 23.68 ? 125 ARG A CB 1 ATOM 965 N N . ASP A 1 126 ? 6.597 -6.746 6.214 1.00 22.30 ? 126 ASP A N 1 ATOM 966 C CA . ASP A 1 126 ? 6.347 -5.963 4.999 1.00 22.21 ? 126 ASP A CA 1 ATOM 967 C C . ASP A 1 126 ? 7.154 -4.668 5.118 1.00 21.10 ? 126 ASP A C 1 ATOM 968 O O . ASP A 1 126 ? 8.012 -4.547 5.999 1.00 21.72 ? 126 ASP A O 1 ATOM 969 C CB . ASP A 1 126 ? 4.861 -5.633 4.828 1.00 22.39 ? 126 ASP A CB 1 ATOM 970 C CG . ASP A 1 126 ? 4.276 -5.004 6.064 1.00 25.81 ? 126 ASP A CG 1 ATOM 971 O OD1 . ASP A 1 126 ? 4.995 -4.213 6.713 1.00 27.19 ? 126 ASP A OD1 1 ATOM 972 O OD2 . ASP A 1 126 ? 3.124 -5.271 6.498 1.00 28.26 ? 126 ASP A OD2 1 ATOM 973 N N . GLY A 1 127 ? 6.872 -3.697 4.258 1.00 20.00 ? 127 GLY A N 1 ATOM 974 C CA . GLY A 1 127 ? 7.587 -2.445 4.277 1.00 19.01 ? 127 GLY A CA 1 ATOM 975 C C . GLY A 1 127 ? 6.951 -1.311 5.055 1.00 18.79 ? 127 GLY A C 1 ATOM 976 O O . GLY A 1 127 ? 7.404 -0.163 4.946 1.00 18.19 ? 127 GLY A O 1 ATOM 977 N N . SER A 1 128 ? 5.918 -1.618 5.842 1.00 18.21 ? 128 SER A N 1 ATOM 978 C CA . SER A 1 128 ? 5.133 -0.587 6.557 1.00 18.51 ? 128 SER A CA 1 ATOM 979 C C . SER A 1 128 ? 5.859 0.270 7.595 1.00 18.76 ? 128 SER A C 1 ATOM 980 O O . SER A 1 128 ? 5.432 1.376 7.894 1.00 18.11 ? 128 SER A O 1 ATOM 981 C CB . SER A 1 128 ? 3.868 -1.204 7.190 1.00 18.61 ? 128 SER A CB 1 ATOM 982 O OG . SER A 1 128 ? 4.216 -2.214 8.102 1.00 17.52 ? 128 SER A OG 1 ATOM 983 N N . ASP A 1 129 ? 6.943 -0.228 8.164 1.00 18.65 ? 129 ASP A N 1 ATOM 984 C CA . ASP A 1 129 ? 7.695 0.602 9.095 1.00 19.45 ? 129 ASP A CA 1 ATOM 985 C C . ASP A 1 129 ? 8.761 1.466 8.371 1.00 19.08 ? 129 ASP A C 1 ATOM 986 O O . ASP A 1 129 ? 9.478 2.261 9.008 1.00 20.00 ? 129 ASP A O 1 ATOM 987 C CB . ASP A 1 129 ? 8.400 -0.288 10.104 1.00 19.45 ? 129 ASP A CB 1 ATOM 988 C CG . ASP A 1 129 ? 9.072 0.509 11.188 1.00 22.31 ? 129 ASP A CG 1 ATOM 989 O OD1 . ASP A 1 129 ? 8.335 1.365 11.725 1.00 21.99 ? 129 ASP A OD1 1 ATOM 990 O OD2 . ASP A 1 129 ? 10.306 0.378 11.544 1.00 21.73 ? 129 ASP A OD2 1 ATOM 991 N N . TRP A 1 130 ? 8.857 1.335 7.054 1.00 18.20 ? 130 TRP A N 1 ATOM 992 C CA . TRP A 1 130 ? 10.023 1.890 6.328 1.00 18.29 ? 130 TRP A CA 1 ATOM 993 C C . TRP A 1 130 ? 9.797 2.972 5.292 1.00 18.43 ? 130 TRP A C 1 ATOM 994 O O . TRP A 1 130 ? 8.825 2.935 4.567 1.00 18.74 ? 130 TRP A O 1 ATOM 995 C CB . TRP A 1 130 ? 10.728 0.720 5.605 1.00 17.10 ? 130 TRP A CB 1 ATOM 996 C CG . TRP A 1 130 ? 11.544 1.093 4.431 1.00 17.33 ? 130 TRP A CG 1 ATOM 997 C CD1 . TRP A 1 130 ? 12.853 1.446 4.430 1.00 14.88 ? 130 TRP A CD1 1 ATOM 998 C CD2 . TRP A 1 130 ? 11.113 1.145 3.059 1.00 16.97 ? 130 TRP A CD2 1 ATOM 999 N NE1 . TRP A 1 130 ? 13.276 1.688 3.149 1.00 13.95 ? 130 TRP A NE1 1 ATOM 1000 C CE2 . TRP A 1 130 ? 12.231 1.502 2.285 1.00 15.47 ? 130 TRP A CE2 1 ATOM 1001 C CE3 . TRP A 1 130 ? 9.895 0.902 2.409 1.00 19.26 ? 130 TRP A CE3 1 ATOM 1002 C CZ2 . TRP A 1 130 ? 12.178 1.658 0.908 1.00 16.26 ? 130 TRP A CZ2 1 ATOM 1003 C CZ3 . TRP A 1 130 ? 9.834 1.043 1.033 1.00 19.65 ? 130 TRP A CZ3 1 ATOM 1004 C CH2 . TRP A 1 130 ? 10.990 1.415 0.295 1.00 20.31 ? 130 TRP A CH2 1 ATOM 1005 N N . GLU A 1 131 ? 10.747 3.891 5.162 1.00 18.53 ? 131 GLU A N 1 ATOM 1006 C CA . GLU A 1 131 ? 10.672 4.854 4.078 1.00 18.81 ? 131 GLU A CA 1 ATOM 1007 C C . GLU A 1 131 ? 12.061 5.209 3.623 1.00 18.10 ? 131 GLU A C 1 ATOM 1008 O O . GLU A 1 131 ? 12.915 5.475 4.463 1.00 16.93 ? 131 GLU A O 1 ATOM 1009 C CB . GLU A 1 131 ? 10.019 6.146 4.539 1.00 19.26 ? 131 GLU A CB 1 ATOM 1010 C CG . GLU A 1 131 ? 8.548 6.201 4.241 1.00 24.61 ? 131 GLU A CG 1 ATOM 1011 C CD . GLU A 1 131 ? 7.911 7.476 4.739 1.00 27.74 ? 131 GLU A CD 1 ATOM 1012 O OE1 . GLU A 1 131 ? 8.537 8.203 5.528 1.00 25.61 ? 131 GLU A OE1 1 ATOM 1013 O OE2 . GLU A 1 131 ? 6.772 7.744 4.312 1.00 33.62 ? 131 GLU A OE2 1 ATOM 1014 N N . PRO A 1 132 ? 12.263 5.288 2.305 1.00 18.02 ? 132 PRO A N 1 ATOM 1015 C CA . PRO A 1 132 ? 13.578 5.679 1.753 1.00 17.92 ? 132 PRO A CA 1 ATOM 1016 C C . PRO A 1 132 ? 13.530 7.192 1.620 1.00 17.87 ? 132 PRO A C 1 ATOM 1017 O O . PRO A 1 132 ? 12.662 7.682 0.877 1.00 17.96 ? 132 PRO A O 1 ATOM 1018 C CB . PRO A 1 132 ? 13.579 5.061 0.353 1.00 16.62 ? 132 PRO A CB 1 ATOM 1019 C CG . PRO A 1 132 ? 12.114 4.812 0.014 1.00 18.49 ? 132 PRO A CG 1 ATOM 1020 C CD . PRO A 1 132 ? 11.242 5.081 1.252 1.00 18.01 ? 132 PRO A CD 1 ATOM 1021 N N . LEU A 1 133 ? 14.345 7.927 2.364 1.00 17.43 ? 133 LEU A N 1 ATOM 1022 C CA . LEU A 1 133 ? 14.282 9.387 2.298 1.00 17.62 ? 133 LEU A CA 1 ATOM 1023 C C . LEU A 1 133 ? 15.437 9.996 1.488 1.00 17.72 ? 133 LEU A C 1 ATOM 1024 O O . LEU A 1 133 ? 16.578 9.593 1.651 1.00 18.39 ? 133 LEU A O 1 ATOM 1025 C CB . LEU A 1 133 ? 14.316 9.959 3.726 1.00 17.57 ? 133 LEU A CB 1 ATOM 1026 C CG . LEU A 1 133 ? 13.167 9.526 4.614 1.00 17.65 ? 133 LEU A CG 1 ATOM 1027 C CD1 . LEU A 1 133 ? 13.285 10.179 5.972 1.00 18.36 ? 133 LEU A CD1 1 ATOM 1028 C CD2 . LEU A 1 133 ? 11.871 9.946 3.934 1.00 17.61 ? 133 LEU A CD2 1 ATOM 1029 N N . LEU A 1 134 ? 15.127 10.961 0.621 1.00 17.60 ? 134 LEU A N 1 ATOM 1030 C CA . LEU A 1 134 ? 16.104 11.713 -0.161 1.00 16.68 ? 134 LEU A CA 1 ATOM 1031 C C . LEU A 1 134 ? 16.136 13.116 0.406 1.00 16.91 ? 134 LEU A C 1 ATOM 1032 O O . LEU A 1 134 ? 15.096 13.748 0.593 1.00 16.85 ? 134 LEU A O 1 ATOM 1033 C CB . LEU A 1 134 ? 15.703 11.781 -1.623 1.00 16.14 ? 134 LEU A CB 1 ATOM 1034 C CG . LEU A 1 134 ? 16.641 12.614 -2.506 1.00 16.58 ? 134 LEU A CG 1 ATOM 1035 C CD1 . LEU A 1 134 ? 18.033 12.038 -2.581 1.00 18.48 ? 134 LEU A CD1 1 ATOM 1036 C CD2 . LEU A 1 134 ? 16.059 12.776 -3.900 1.00 15.18 ? 134 LEU A CD2 1 ATOM 1037 N N . VAL A 1 135 ? 17.334 13.598 0.689 1.00 17.13 ? 135 VAL A N 1 ATOM 1038 C CA . VAL A 1 135 ? 17.528 14.911 1.283 1.00 16.61 ? 135 VAL A CA 1 ATOM 1039 C C . VAL A 1 135 ? 18.557 15.683 0.493 1.00 16.91 ? 135 VAL A C 1 ATOM 1040 O O . VAL A 1 135 ? 19.657 15.159 0.187 1.00 17.22 ? 135 VAL A O 1 ATOM 1041 C CB . VAL A 1 135 ? 17.983 14.773 2.744 1.00 17.18 ? 135 VAL A CB 1 ATOM 1042 C CG1 . VAL A 1 135 ? 18.479 16.090 3.330 1.00 16.66 ? 135 VAL A CG1 1 ATOM 1043 C CG2 . VAL A 1 135 ? 16.858 14.258 3.610 1.00 18.76 ? 135 VAL A CG2 1 ATOM 1044 N N . VAL A 1 136 ? 18.270 16.942 0.188 1.00 16.70 ? 136 VAL A N 1 ATOM 1045 C CA . VAL A 1 136 ? 19.224 17.738 -0.583 1.00 16.78 ? 136 VAL A CA 1 ATOM 1046 C C . VAL A 1 136 ? 19.909 18.817 0.251 1.00 17.42 ? 136 VAL A C 1 ATOM 1047 O O . VAL A 1 136 ? 19.274 19.617 0.910 1.00 17.97 ? 136 VAL A O 1 ATOM 1048 C CB . VAL A 1 136 ? 18.532 18.414 -1.799 1.00 17.52 ? 136 VAL A CB 1 ATOM 1049 C CG1 . VAL A 1 136 ? 19.522 19.339 -2.543 1.00 16.37 ? 136 VAL A CG1 1 ATOM 1050 C CG2 . VAL A 1 136 ? 17.923 17.374 -2.718 1.00 17.13 ? 136 VAL A CG2 1 ATOM 1051 N N . GLY A 1 137 ? 21.220 18.856 0.243 1.00 17.82 ? 137 GLY A N 1 ATOM 1052 C CA . GLY A 1 137 ? 21.861 19.926 0.968 1.00 18.80 ? 137 GLY A CA 1 ATOM 1053 C C . GLY A 1 137 ? 22.587 20.861 0.014 1.00 20.63 ? 137 GLY A C 1 ATOM 1054 O O . GLY A 1 137 ? 23.052 20.452 -1.039 1.00 19.96 ? 137 GLY A O 1 ATOM 1055 N N . GLU A 1 138 ? 22.686 22.127 0.383 1.00 21.84 ? 138 GLU A N 1 ATOM 1056 C CA . GLU A 1 138 ? 23.286 23.098 -0.508 1.00 23.73 ? 138 GLU A CA 1 ATOM 1057 C C . GLU A 1 138 ? 24.403 23.837 0.168 1.00 23.93 ? 138 GLU A C 1 ATOM 1058 O O . GLU A 1 138 ? 24.194 24.462 1.209 1.00 23.83 ? 138 GLU A O 1 ATOM 1059 C CB . GLU A 1 138 ? 22.248 24.106 -0.979 1.00 23.90 ? 138 GLU A CB 1 ATOM 1060 C CG . GLU A 1 138 ? 22.832 25.101 -1.962 1.00 27.60 ? 138 GLU A CG 1 ATOM 1061 C CD . GLU A 1 138 ? 21.753 25.967 -2.618 1.00 34.01 ? 138 GLU A CD 1 ATOM 1062 O OE1 . GLU A 1 138 ? 20.573 25.529 -2.645 1.00 36.49 ? 138 GLU A OE1 1 ATOM 1063 O OE2 . GLU A 1 138 ? 22.080 27.068 -3.102 1.00 33.06 ? 138 GLU A OE2 1 ATOM 1064 N N . VAL A 1 139 ? 25.583 23.781 -0.438 1.00 24.54 ? 139 VAL A N 1 ATOM 1065 C CA . VAL A 1 139 ? 26.729 24.457 0.119 1.00 25.79 ? 139 VAL A CA 1 ATOM 1066 C C . VAL A 1 139 ? 26.960 25.857 -0.457 1.00 27.44 ? 139 VAL A C 1 ATOM 1067 O O . VAL A 1 139 ? 26.958 26.074 -1.680 1.00 26.70 ? 139 VAL A O 1 ATOM 1068 C CB . VAL A 1 139 ? 27.999 23.606 -0.027 1.00 25.55 ? 139 VAL A CB 1 ATOM 1069 C CG1 . VAL A 1 139 ? 29.202 24.363 0.477 1.00 23.86 ? 139 VAL A CG1 1 ATOM 1070 C CG2 . VAL A 1 139 ? 27.821 22.300 0.733 1.00 25.82 ? 139 VAL A CG2 1 ATOM 1071 N N . THR A 1 140 ? 27.184 26.790 0.461 1.00 29.22 ? 140 THR A N 1 ATOM 1072 C CA . THR A 1 140 ? 27.389 28.191 0.153 1.00 31.62 ? 140 THR A CA 1 ATOM 1073 C C . THR A 1 140 ? 28.686 28.623 0.811 1.00 32.98 ? 140 THR A C 1 ATOM 1074 O O . THR A 1 140 ? 28.813 28.611 2.036 1.00 31.98 ? 140 THR A O 1 ATOM 1075 C CB . THR A 1 140 ? 26.209 29.016 0.721 1.00 31.56 ? 140 THR A CB 1 ATOM 1076 O OG1 . THR A 1 140 ? 25.011 28.665 0.031 1.00 32.20 ? 140 THR A OG1 1 ATOM 1077 C CG2 . THR A 1 140 ? 26.384 30.500 0.416 1.00 32.51 ? 140 THR A CG2 1 ATOM 1078 N N . LYS A 1 141 ? 29.651 29.000 -0.011 1.00 35.61 ? 141 LYS A N 1 ATOM 1079 C CA . LYS A 1 141 ? 30.939 29.404 0.486 1.00 38.62 ? 141 LYS A CA 1 ATOM 1080 C C . LYS A 1 141 ? 31.086 30.881 0.364 1.00 41.31 ? 141 LYS A C 1 ATOM 1081 O O . LYS A 1 141 ? 31.301 31.368 -0.741 1.00 42.63 ? 141 LYS A O 1 ATOM 1082 C CB . LYS A 1 141 ? 32.042 28.830 -0.396 1.00 38.53 ? 141 LYS A CB 1 ATOM 1083 C CG . LYS A 1 141 ? 32.840 27.703 0.185 1.00 38.16 ? 141 LYS A CG 1 ATOM 1084 C CD . LYS A 1 141 ? 34.169 27.592 -0.554 1.00 37.62 ? 141 LYS A CD 1 ATOM 1085 C CE . LYS A 1 141 ? 33.965 27.702 -2.054 1.00 39.53 ? 141 LYS A CE 1 ATOM 1086 N NZ . LYS A 1 141 ? 35.151 27.196 -2.785 1.00 39.76 ? 141 LYS A NZ 1 ATOM 1087 N N . SER A 1 142 ? 30.975 31.623 1.453 1.00 43.79 ? 142 SER A N 1 ATOM 1088 C CA . SER A 1 142 ? 31.391 33.005 1.337 1.00 46.34 ? 142 SER A CA 1 ATOM 1089 C C . SER A 1 142 ? 32.816 33.086 1.890 1.00 48.02 ? 142 SER A C 1 ATOM 1090 O O . SER A 1 142 ? 33.697 32.294 1.531 1.00 48.34 ? 142 SER A O 1 ATOM 1091 C CB . SER A 1 142 ? 30.430 33.985 2.019 1.00 46.43 ? 142 SER A CB 1 ATOM 1092 O OG . SER A 1 142 ? 30.076 33.566 3.316 1.00 46.59 ? 142 SER A OG 1 ATOM 1093 N N . ALA A 1 143 ? 33.027 34.040 2.776 1.00 50.20 ? 143 ALA A N 1 ATOM 1094 C CA . ALA A 1 143 ? 34.317 34.276 3.403 1.00 52.43 ? 143 ALA A CA 1 ATOM 1095 C C . ALA A 1 143 ? 34.262 35.680 3.961 1.00 53.76 ? 143 ALA A C 1 ATOM 1096 O O . ALA A 1 143 ? 33.190 36.206 4.246 1.00 54.43 ? 143 ALA A O 1 ATOM 1097 C CB . ALA A 1 143 ? 35.492 34.151 2.394 1.00 52.47 ? 143 ALA A CB 1 ATOM 1098 N N . ALA A 1 144 ? 35.428 36.291 4.093 1.00 55.34 ? 144 ALA A N 1 ATOM 1099 C CA . ALA A 1 144 ? 35.550 37.634 4.627 1.00 56.19 ? 144 ALA A CA 1 ATOM 1100 C C . ALA A 1 144 ? 37.031 37.945 4.561 1.00 56.71 ? 144 ALA A C 1 ATOM 1101 O O . ALA A 1 144 ? 37.825 37.109 4.104 1.00 56.95 ? 144 ALA A O 1 ATOM 1102 C CB . ALA A 1 144 ? 35.040 37.687 6.072 1.00 56.32 ? 144 ALA A CB 1 ATOM 1103 N N . ASN A 1 145 ? 37.404 39.143 4.996 1.00 57.24 ? 145 ASN A N 1 ATOM 1104 C CA . ASN A 1 145 ? 38.808 39.535 5.006 1.00 57.41 ? 145 ASN A CA 1 ATOM 1105 C C . ASN A 1 145 ? 39.749 38.389 5.415 1.00 56.67 ? 145 ASN A C 1 ATOM 1106 O O . ASN A 1 145 ? 39.994 38.140 6.608 1.00 56.28 ? 145 ASN A O 1 ATOM 1107 C CB . ASN A 1 145 ? 39.034 40.776 5.880 1.00 58.02 ? 145 ASN A CB 1 ATOM 1108 C CG . ASN A 1 145 ? 38.305 40.699 7.224 1.00 59.79 ? 145 ASN A CG 1 ATOM 1109 O OD1 . ASN A 1 145 ? 38.075 41.731 7.867 1.00 61.48 ? 145 ASN A OD1 1 ATOM 1110 N ND2 . ASN A 1 145 ? 37.951 39.479 7.659 1.00 60.81 ? 145 ASN A ND2 1 ATOM 1111 N N . GLY A 1 146 ? 40.240 37.675 4.406 1.00 55.68 ? 146 GLY A N 1 ATOM 1112 C CA . GLY A 1 146 ? 41.221 36.637 4.638 1.00 54.68 ? 146 GLY A CA 1 ATOM 1113 C C . GLY A 1 146 ? 40.773 35.304 5.205 1.00 53.80 ? 146 GLY A C 1 ATOM 1114 O O . GLY A 1 146 ? 41.621 34.439 5.460 1.00 54.27 ? 146 GLY A O 1 ATOM 1115 N N . LYS A 1 147 ? 39.474 35.112 5.424 1.00 52.13 ? 147 LYS A N 1 ATOM 1116 C CA . LYS A 1 147 ? 39.026 33.815 5.930 1.00 50.43 ? 147 LYS A CA 1 ATOM 1117 C C . LYS A 1 147 ? 37.725 33.375 5.285 1.00 48.53 ? 147 LYS A C 1 ATOM 1118 O O . LYS A 1 147 ? 36.687 34.000 5.464 1.00 48.72 ? 147 LYS A O 1 ATOM 1119 C CB . LYS A 1 147 ? 38.916 33.810 7.465 1.00 50.90 ? 147 LYS A CB 1 ATOM 1120 C CG . LYS A 1 147 ? 40.068 33.073 8.181 1.00 52.13 ? 147 LYS A CG 1 ATOM 1121 C CD . LYS A 1 147 ? 41.346 33.925 8.360 1.00 54.27 ? 147 LYS A CD 1 ATOM 1122 C CE . LYS A 1 147 ? 41.432 34.629 9.746 1.00 55.95 ? 147 LYS A CE 1 ATOM 1123 N NZ . LYS A 1 147 ? 40.241 35.473 10.131 1.00 54.98 ? 147 LYS A NZ 1 ATOM 1124 N N . THR A 1 148 ? 37.802 32.311 4.504 1.00 45.93 ? 148 THR A N 1 ATOM 1125 C CA . THR A 1 148 ? 36.629 31.733 3.875 1.00 43.04 ? 148 THR A CA 1 ATOM 1126 C C . THR A 1 148 ? 35.685 31.142 4.933 1.00 40.82 ? 148 THR A C 1 ATOM 1127 O O . THR A 1 148 ? 36.143 30.716 5.983 1.00 40.34 ? 148 THR A O 1 ATOM 1128 C CB . THR A 1 148 ? 37.100 30.638 2.912 1.00 43.45 ? 148 THR A CB 1 ATOM 1129 O OG1 . THR A 1 148 ? 37.730 31.240 1.776 1.00 42.81 ? 148 THR A OG1 1 ATOM 1130 C CG2 . THR A 1 148 ? 35.919 29.901 2.303 1.00 44.00 ? 148 THR A CG2 1 ATOM 1131 N N . THR A 1 149 ? 34.373 31.158 4.701 1.00 38.16 ? 149 THR A N 1 ATOM 1132 C CA . THR A 1 149 ? 33.469 30.452 5.605 1.00 35.62 ? 149 THR A CA 1 ATOM 1133 C C . THR A 1 149 ? 32.461 29.745 4.764 1.00 34.03 ? 149 THR A C 1 ATOM 1134 O O . THR A 1 149 ? 32.345 30.011 3.583 1.00 33.38 ? 149 THR A O 1 ATOM 1135 C CB . THR A 1 149 ? 32.684 31.360 6.570 1.00 35.70 ? 149 THR A CB 1 ATOM 1136 O OG1 . THR A 1 149 ? 32.060 32.410 5.826 1.00 35.79 ? 149 THR A OG1 1 ATOM 1137 C CG2 . THR A 1 149 ? 33.600 32.039 7.576 1.00 35.20 ? 149 THR A CG2 1 ATOM 1138 N N . ALA A 1 150 ? 31.692 28.874 5.398 1.00 32.19 ? 150 ALA A N 1 ATOM 1139 C CA . ALA A 1 150 ? 30.703 28.133 4.674 1.00 30.70 ? 150 ALA A CA 1 ATOM 1140 C C . ALA A 1 150 ? 29.534 27.787 5.543 1.00 29.85 ? 150 ALA A C 1 ATOM 1141 O O . ALA A 1 150 ? 29.657 27.684 6.746 1.00 30.02 ? 150 ALA A O 1 ATOM 1142 C CB . ALA A 1 150 ? 31.321 26.863 4.133 1.00 30.68 ? 150 ALA A CB 1 ATOM 1143 N N . THR A 1 151 ? 28.388 27.619 4.911 1.00 28.88 ? 151 THR A N 1 ATOM 1144 C CA . THR A 1 151 ? 27.214 27.100 5.575 1.00 28.78 ? 151 THR A CA 1 ATOM 1145 C C . THR A 1 151 ? 26.643 26.021 4.665 1.00 26.95 ? 151 THR A C 1 ATOM 1146 O O . THR A 1 151 ? 26.943 25.952 3.472 1.00 26.80 ? 151 THR A O 1 ATOM 1147 C CB . THR A 1 151 ? 26.106 28.197 5.809 1.00 29.53 ? 151 THR A CB 1 ATOM 1148 O OG1 . THR A 1 151 ? 25.613 28.665 4.546 1.00 31.51 ? 151 THR A OG1 1 ATOM 1149 C CG2 . THR A 1 151 ? 26.686 29.461 6.461 1.00 29.98 ? 151 THR A CG2 1 ATOM 1150 N N . ILE A 1 152 ? 25.821 25.166 5.230 1.00 25.23 ? 152 ILE A N 1 ATOM 1151 C CA . ILE A 1 152 ? 25.164 24.177 4.432 1.00 24.13 ? 152 ILE A CA 1 ATOM 1152 C C . ILE A 1 152 ? 23.741 24.200 4.889 1.00 24.17 ? 152 ILE A C 1 ATOM 1153 O O . ILE A 1 152 ? 23.466 24.170 6.084 1.00 23.58 ? 152 ILE A O 1 ATOM 1154 C CB . ILE A 1 152 ? 25.758 22.800 4.635 1.00 23.63 ? 152 ILE A CB 1 ATOM 1155 C CG1 . ILE A 1 152 ? 27.262 22.817 4.350 1.00 23.19 ? 152 ILE A CG1 1 ATOM 1156 C CG2 . ILE A 1 152 ? 25.065 21.828 3.714 1.00 22.47 ? 152 ILE A CG2 1 ATOM 1157 C CD1 . ILE A 1 152 ? 27.939 21.476 4.529 1.00 23.15 ? 152 ILE A CD1 1 ATOM 1158 N N . SER A 1 153 ? 22.833 24.258 3.941 1.00 24.18 ? 153 SER A N 1 ATOM 1159 C CA . SER A 1 153 ? 21.420 24.298 4.290 1.00 25.87 ? 153 SER A CA 1 ATOM 1160 C C . SER A 1 153 ? 20.757 22.978 3.824 1.00 25.77 ? 153 SER A C 1 ATOM 1161 O O . SER A 1 153 ? 20.972 22.521 2.702 1.00 25.51 ? 153 SER A O 1 ATOM 1162 C CB . SER A 1 153 ? 20.804 25.561 3.670 1.00 25.86 ? 153 SER A CB 1 ATOM 1163 O OG . SER A 1 153 ? 19.426 25.441 3.381 1.00 28.94 ? 153 SER A OG 1 ATOM 1164 N N . TRP A 1 154 ? 19.975 22.363 4.703 1.00 25.66 ? 154 TRP A N 1 ATOM 1165 C CA . TRP A 1 154 ? 19.384 21.067 4.422 1.00 25.09 ? 154 TRP A CA 1 ATOM 1166 C C . TRP A 1 154 ? 17.885 21.153 4.178 1.00 26.22 ? 154 TRP A C 1 ATOM 1167 O O . TRP A 1 154 ? 17.156 21.669 5.016 1.00 26.49 ? 154 TRP A O 1 ATOM 1168 C CB . TRP A 1 154 ? 19.686 20.101 5.581 1.00 24.84 ? 154 TRP A CB 1 ATOM 1169 C CG . TRP A 1 154 ? 21.173 19.833 5.764 1.00 22.07 ? 154 TRP A CG 1 ATOM 1170 C CD1 . TRP A 1 154 ? 22.003 20.364 6.713 1.00 19.53 ? 154 TRP A CD1 1 ATOM 1171 C CD2 . TRP A 1 154 ? 21.983 19.002 4.949 1.00 19.88 ? 154 TRP A CD2 1 ATOM 1172 N NE1 . TRP A 1 154 ? 23.283 19.912 6.535 1.00 17.76 ? 154 TRP A NE1 1 ATOM 1173 C CE2 . TRP A 1 154 ? 23.296 19.062 5.456 1.00 19.41 ? 154 TRP A CE2 1 ATOM 1174 C CE3 . TRP A 1 154 ? 21.731 18.183 3.842 1.00 21.17 ? 154 TRP A CE3 1 ATOM 1175 C CZ2 . TRP A 1 154 ? 24.351 18.350 4.887 1.00 18.03 ? 154 TRP A CZ2 1 ATOM 1176 C CZ3 . TRP A 1 154 ? 22.795 17.482 3.268 1.00 19.87 ? 154 TRP A CZ3 1 ATOM 1177 C CH2 . TRP A 1 154 ? 24.083 17.567 3.804 1.00 18.13 ? 154 TRP A CH2 1 ATOM 1178 N N . GLY A 1 155 ? 17.423 20.622 3.043 1.00 26.22 ? 155 GLY A N 1 ATOM 1179 C CA . GLY A 1 155 ? 16.008 20.619 2.709 1.00 26.36 ? 155 GLY A CA 1 ATOM 1180 C C . GLY A 1 155 ? 15.193 19.637 3.539 1.00 26.83 ? 155 GLY A C 1 ATOM 1181 O O . GLY A 1 155 ? 15.724 18.929 4.402 1.00 26.81 ? 155 GLY A O 1 ATOM 1182 N N . LYS A 1 156 ? 13.886 19.603 3.310 1.00 26.77 ? 156 LYS A N 1 ATOM 1183 C CA . LYS A 1 156 ? 13.068 18.651 4.027 1.00 27.02 ? 156 LYS A CA 1 ATOM 1184 C C . LYS A 1 156 ? 13.219 17.357 3.277 1.00 26.40 ? 156 LYS A C 1 ATOM 1185 O O . LYS A 1 156 ? 13.389 17.352 2.059 1.00 26.67 ? 156 LYS A O 1 ATOM 1186 C CB . LYS A 1 156 ? 11.572 19.074 4.064 1.00 27.66 ? 156 LYS A CB 1 ATOM 1187 N N . PRO A 1 157 ? 13.191 16.265 4.009 1.00 25.75 ? 157 PRO A N 1 ATOM 1188 C CA . PRO A 1 157 ? 13.296 14.937 3.410 1.00 25.18 ? 157 PRO A CA 1 ATOM 1189 C C . PRO A 1 157 ? 12.128 14.672 2.479 1.00 24.70 ? 157 PRO A C 1 ATOM 1190 O O . PRO A 1 157 ? 11.014 15.124 2.713 1.00 23.87 ? 157 PRO A O 1 ATOM 1191 C CB . PRO A 1 157 ? 13.220 14.016 4.616 1.00 25.12 ? 157 PRO A CB 1 ATOM 1192 C CG . PRO A 1 157 ? 13.677 14.879 5.751 1.00 25.86 ? 157 PRO A CG 1 ATOM 1193 C CD . PRO A 1 157 ? 13.107 16.230 5.477 1.00 25.48 ? 157 PRO A CD 1 ATOM 1194 N N . VAL A 1 158 ? 12.388 13.927 1.423 1.00 24.02 ? 158 VAL A N 1 ATOM 1195 C CA . VAL A 1 158 ? 11.326 13.565 0.517 1.00 24.44 ? 158 VAL A CA 1 ATOM 1196 C C . VAL A 1 158 ? 11.303 12.052 0.414 1.00 24.04 ? 158 VAL A C 1 ATOM 1197 O O . VAL A 1 158 ? 12.381 11.416 0.304 1.00 24.10 ? 158 VAL A O 1 ATOM 1198 C CB . VAL A 1 158 ? 11.506 14.230 -0.849 1.00 24.45 ? 158 VAL A CB 1 ATOM 1199 C CG1 . VAL A 1 158 ? 10.594 13.597 -1.839 1.00 25.24 ? 158 VAL A CG1 1 ATOM 1200 C CG2 . VAL A 1 158 ? 11.191 15.723 -0.732 1.00 25.67 ? 158 VAL A CG2 1 ATOM 1201 N N . SER A 1 159 ? 10.107 11.470 0.488 1.00 23.21 ? 159 SER A N 1 ATOM 1202 C CA . SER A 1 159 ? 10.016 10.027 0.427 1.00 22.69 ? 159 SER A CA 1 ATOM 1203 C C . SER A 1 159 ? 9.970 9.602 -1.012 1.00 22.25 ? 159 SER A C 1 ATOM 1204 O O . SER A 1 159 ? 9.285 10.218 -1.813 1.00 22.56 ? 159 SER A O 1 ATOM 1205 C CB . SER A 1 159 ? 8.802 9.507 1.186 1.00 22.17 ? 159 SER A CB 1 ATOM 1206 O OG . SER A 1 159 ? 8.747 8.093 1.109 1.00 22.55 ? 159 SER A OG 1 ATOM 1207 N N . LEU A 1 160 ? 10.694 8.531 -1.329 1.00 22.24 ? 160 LEU A N 1 ATOM 1208 C CA . LEU A 1 160 ? 10.769 7.982 -2.675 1.00 20.98 ? 160 LEU A CA 1 ATOM 1209 C C . LEU A 1 160 ? 9.992 6.682 -2.693 1.00 20.53 ? 160 LEU A C 1 ATOM 1210 O O . LEU A 1 160 ? 10.068 5.904 -3.621 1.00 19.58 ? 160 LEU A O 1 ATOM 1211 C CB . LEU A 1 160 ? 12.216 7.668 -3.012 1.00 21.14 ? 160 LEU A CB 1 ATOM 1212 C CG . LEU A 1 160 ? 13.231 8.794 -3.126 1.00 23.02 ? 160 LEU A CG 1 ATOM 1213 C CD1 . LEU A 1 160 ? 14.513 8.270 -3.872 1.00 21.95 ? 160 LEU A CD1 1 ATOM 1214 C CD2 . LEU A 1 160 ? 12.610 9.987 -3.863 1.00 25.20 ? 160 LEU A CD2 1 ATOM 1215 N N . LYS A 1 161 ? 9.274 6.414 -1.620 1.00 21.29 ? 161 LYS A N 1 ATOM 1216 C CA . LYS A 1 161 ? 8.502 5.169 -1.542 1.00 21.24 ? 161 LYS A CA 1 ATOM 1217 C C . LYS A 1 161 ? 7.492 4.973 -2.676 1.00 21.81 ? 161 LYS A C 1 ATOM 1218 O O . LYS A 1 161 ? 7.352 3.867 -3.206 1.00 20.58 ? 161 LYS A O 1 ATOM 1219 C CB . LYS A 1 161 ? 7.858 5.039 -0.169 1.00 21.23 ? 161 LYS A CB 1 ATOM 1220 C CG . LYS A 1 161 ? 7.085 3.741 0.076 1.00 21.47 ? 161 LYS A CG 1 ATOM 1221 C CD . LYS A 1 161 ? 7.047 3.492 1.576 1.00 23.18 ? 161 LYS A CD 1 ATOM 1222 C CE . LYS A 1 161 ? 6.275 2.246 1.969 1.00 23.82 ? 161 LYS A CE 1 ATOM 1223 N NZ . LYS A 1 161 ? 6.412 2.057 3.450 1.00 24.09 ? 161 LYS A NZ 1 ATOM 1224 N N . PRO A 1 162 ? 6.771 6.019 -3.058 1.00 22.77 ? 162 PRO A N 1 ATOM 1225 C CA . PRO A 1 162 ? 5.846 5.889 -4.212 1.00 24.10 ? 162 PRO A CA 1 ATOM 1226 C C . PRO A 1 162 ? 6.527 5.493 -5.538 1.00 24.76 ? 162 PRO A C 1 ATOM 1227 O O . PRO A 1 162 ? 5.827 5.024 -6.439 1.00 24.70 ? 162 PRO A O 1 ATOM 1228 C CB . PRO A 1 162 ? 5.221 7.286 -4.353 1.00 24.14 ? 162 PRO A CB 1 ATOM 1229 C CG . PRO A 1 162 ? 5.405 7.928 -2.955 1.00 23.74 ? 162 PRO A CG 1 ATOM 1230 C CD . PRO A 1 162 ? 6.711 7.344 -2.424 1.00 22.52 ? 162 PRO A CD 1 ATOM 1231 N N . LEU A 1 163 ? 7.842 5.682 -5.674 1.00 25.35 ? 163 LEU A N 1 ATOM 1232 C CA . LEU A 1 163 ? 8.507 5.356 -6.935 1.00 25.62 ? 163 LEU A CA 1 ATOM 1233 C C . LEU A 1 163 ? 9.010 3.911 -6.938 1.00 26.23 ? 163 LEU A C 1 ATOM 1234 O O . LEU A 1 163 ? 9.616 3.450 -7.910 1.00 26.24 ? 163 LEU A O 1 ATOM 1235 C CB . LEU A 1 163 ? 9.713 6.284 -7.184 1.00 26.26 ? 163 LEU A CB 1 ATOM 1236 C CG . LEU A 1 163 ? 9.703 7.794 -6.876 1.00 26.34 ? 163 LEU A CG 1 ATOM 1237 C CD1 . LEU A 1 163 ? 10.980 8.462 -7.346 1.00 24.42 ? 163 LEU A CD1 1 ATOM 1238 C CD2 . LEU A 1 163 ? 8.470 8.521 -7.480 1.00 28.94 ? 163 LEU A CD2 1 ATOM 1239 N N . PHE A 1 164 ? 8.801 3.205 -5.835 1.00 26.37 ? 164 PHE A N 1 ATOM 1240 C CA . PHE A 1 164 ? 9.339 1.866 -5.694 1.00 26.17 ? 164 PHE A CA 1 ATOM 1241 C C . PHE A 1 164 ? 8.351 0.894 -6.277 1.00 26.72 ? 164 PHE A C 1 ATOM 1242 O O . PHE A 1 164 ? 7.250 0.775 -5.776 1.00 27.22 ? 164 PHE A O 1 ATOM 1243 C CB . PHE A 1 164 ? 9.486 1.538 -4.206 1.00 25.83 ? 164 PHE A CB 1 ATOM 1244 C CG . PHE A 1 164 ? 10.292 0.298 -3.917 1.00 23.98 ? 164 PHE A CG 1 ATOM 1245 C CD1 . PHE A 1 164 ? 11.369 -0.054 -4.712 1.00 21.09 ? 164 PHE A CD1 1 ATOM 1246 C CD2 . PHE A 1 164 ? 10.003 -0.481 -2.805 1.00 22.73 ? 164 PHE A CD2 1 ATOM 1247 C CE1 . PHE A 1 164 ? 12.120 -1.173 -4.424 1.00 21.16 ? 164 PHE A CE1 1 ATOM 1248 C CE2 . PHE A 1 164 ? 10.754 -1.612 -2.519 1.00 20.68 ? 164 PHE A CE2 1 ATOM 1249 C CZ . PHE A 1 164 ? 11.824 -1.943 -3.329 1.00 20.21 ? 164 PHE A CZ 1 ATOM 1250 N N . PRO A 1 165 ? 8.739 0.170 -7.309 1.00 27.09 ? 165 PRO A N 1 ATOM 1251 C CA . PRO A 1 165 ? 7.842 -0.831 -7.873 1.00 27.53 ? 165 PRO A CA 1 ATOM 1252 C C . PRO A 1 165 ? 7.562 -1.911 -6.839 1.00 27.74 ? 165 PRO A C 1 ATOM 1253 O O . PRO A 1 165 ? 8.370 -2.191 -5.909 1.00 27.12 ? 165 PRO A O 1 ATOM 1254 C CB . PRO A 1 165 ? 8.624 -1.401 -9.058 1.00 28.23 ? 165 PRO A CB 1 ATOM 1255 C CG . PRO A 1 165 ? 9.791 -0.474 -9.270 1.00 28.31 ? 165 PRO A CG 1 ATOM 1256 C CD . PRO A 1 165 ? 10.038 0.231 -7.996 1.00 27.16 ? 165 PRO A CD 1 ATOM 1257 N N . ALA A 1 166 ? 6.400 -2.522 -7.020 1.00 27.61 ? 166 ALA A N 1 ATOM 1258 C CA . ALA A 1 166 ? 5.904 -3.548 -6.129 1.00 27.44 ? 166 ALA A CA 1 ATOM 1259 C C . ALA A 1 166 ? 6.513 -4.875 -6.511 1.00 27.40 ? 166 ALA A C 1 ATOM 1260 O O . ALA A 1 166 ? 6.544 -5.823 -5.733 1.00 28.13 ? 166 ALA A O 1 ATOM 1261 C CB . ALA A 1 166 ? 4.371 -3.599 -6.225 1.00 28.16 ? 166 ALA A CB 1 ATOM 1262 N N . GLU A 1 167 ? 7.031 -4.937 -7.726 1.00 27.75 ? 167 GLU A N 1 ATOM 1263 C CA . GLU A 1 167 ? 7.646 -6.156 -8.206 1.00 27.58 ? 167 GLU A CA 1 ATOM 1264 C C . GLU A 1 167 ? 8.696 -5.833 -9.236 1.00 27.88 ? 167 GLU A C 1 ATOM 1265 O O . GLU A 1 167 ? 8.639 -4.793 -9.890 1.00 26.92 ? 167 GLU A O 1 ATOM 1266 C CB . GLU A 1 167 ? 6.593 -7.043 -8.818 1.00 28.24 ? 167 GLU A CB 1 ATOM 1267 N N . PHE A 1 168 ? 9.661 -6.730 -9.368 1.00 28.58 ? 168 PHE A N 1 ATOM 1268 C CA . PHE A 1 168 ? 10.676 -6.647 -10.410 1.00 30.22 ? 168 PHE A CA 1 ATOM 1269 C C . PHE A 1 168 ? 10.663 -8.061 -10.953 1.00 32.21 ? 168 PHE A C 1 ATOM 1270 O O . PHE A 1 168 ? 10.708 -9.001 -10.163 1.00 32.78 ? 168 PHE A O 1 ATOM 1271 C CB . PHE A 1 168 ? 12.077 -6.389 -9.832 1.00 29.39 ? 168 PHE A CB 1 ATOM 1272 C CG . PHE A 1 168 ? 12.324 -4.972 -9.393 1.00 27.10 ? 168 PHE A CG 1 ATOM 1273 C CD1 . PHE A 1 168 ? 12.776 -4.706 -8.111 1.00 25.21 ? 168 PHE A CD1 1 ATOM 1274 C CD2 . PHE A 1 168 ? 12.153 -3.915 -10.263 1.00 25.54 ? 168 PHE A CD2 1 ATOM 1275 C CE1 . PHE A 1 168 ? 13.044 -3.418 -7.703 1.00 23.42 ? 168 PHE A CE1 1 ATOM 1276 C CE2 . PHE A 1 168 ? 12.408 -2.624 -9.862 1.00 22.69 ? 168 PHE A CE2 1 ATOM 1277 C CZ . PHE A 1 168 ? 12.846 -2.375 -8.573 1.00 23.87 ? 168 PHE A CZ 1 ATOM 1278 N N . ASP A 1 169 ? 10.561 -8.240 -12.269 1.00 34.64 ? 169 ASP A N 1 ATOM 1279 C CA . ASP A 1 169 ? 10.641 -9.589 -12.802 1.00 36.65 ? 169 ASP A CA 1 ATOM 1280 C C . ASP A 1 169 ? 9.795 -10.545 -11.996 1.00 37.54 ? 169 ASP A C 1 ATOM 1281 O O . ASP A 1 169 ? 10.208 -11.699 -11.798 1.00 38.38 ? 169 ASP A O 1 ATOM 1282 C CB . ASP A 1 169 ? 12.043 -10.113 -12.575 1.00 37.78 ? 169 ASP A CB 1 ATOM 1283 C CG . ASP A 1 169 ? 12.878 -10.124 -13.805 1.00 40.43 ? 169 ASP A CG 1 ATOM 1284 O OD1 . ASP A 1 169 ? 14.083 -10.424 -13.633 1.00 44.34 ? 169 ASP A OD1 1 ATOM 1285 O OD2 . ASP A 1 169 ? 12.442 -9.865 -14.952 1.00 42.75 ? 169 ASP A OD2 1 ATOM 1286 N N . GLY A 1 170 ? 8.663 -10.086 -11.469 1.00 37.71 ? 170 GLY A N 1 ATOM 1287 C CA . GLY A 1 170 ? 7.831 -10.963 -10.676 1.00 37.76 ? 170 GLY A CA 1 ATOM 1288 C C . GLY A 1 170 ? 8.305 -11.101 -9.232 1.00 38.06 ? 170 GLY A C 1 ATOM 1289 O O . GLY A 1 170 ? 7.622 -11.773 -8.438 1.00 38.16 ? 170 GLY A O 1 ATOM 1290 N N . ILE A 1 171 ? 9.460 -10.501 -8.888 1.00 36.91 ? 171 ILE A N 1 ATOM 1291 C CA . ILE A 1 171 ? 9.962 -10.515 -7.503 1.00 35.59 ? 171 ILE A CA 1 ATOM 1292 C C . ILE A 1 171 ? 9.138 -9.499 -6.691 1.00 34.04 ? 171 ILE A C 1 ATOM 1293 O O . ILE A 1 171 ? 9.170 -8.316 -6.979 1.00 34.36 ? 171 ILE A O 1 ATOM 1294 C CB . ILE A 1 171 ? 11.467 -10.089 -7.448 1.00 35.75 ? 171 ILE A CB 1 ATOM 1295 C CG1 . ILE A 1 171 ? 12.344 -10.886 -8.404 1.00 35.88 ? 171 ILE A CG1 1 ATOM 1296 C CG2 . ILE A 1 171 ? 12.036 -10.224 -6.049 1.00 36.12 ? 171 ILE A CG2 1 ATOM 1297 C CD1 . ILE A 1 171 ? 13.765 -10.330 -8.483 1.00 36.28 ? 171 ILE A CD1 1 ATOM 1298 N N . LEU A 1 172 ? 8.397 -9.922 -5.683 1.00 32.30 ? 172 LEU A N 1 ATOM 1299 C CA . LEU A 1 172 ? 7.657 -8.915 -4.919 1.00 31.32 ? 172 LEU A CA 1 ATOM 1300 C C . LEU A 1 172 ? 8.590 -8.139 -3.970 1.00 28.88 ? 172 LEU A C 1 ATOM 1301 O O . LEU A 1 172 ? 9.341 -8.735 -3.198 1.00 27.99 ? 172 LEU A O 1 ATOM 1302 C CB . LEU A 1 172 ? 6.510 -9.567 -4.168 1.00 32.16 ? 172 LEU A CB 1 ATOM 1303 C CG . LEU A 1 172 ? 6.113 -10.872 -4.874 1.00 35.43 ? 172 LEU A CG 1 ATOM 1304 C CD1 . LEU A 1 172 ? 5.319 -11.829 -3.921 1.00 38.59 ? 172 LEU A CD1 1 ATOM 1305 C CD2 . LEU A 1 172 ? 5.330 -10.590 -6.186 1.00 37.97 ? 172 LEU A CD2 1 ATOM 1306 N N . THR A 1 173 ? 8.547 -6.816 -4.048 1.00 26.34 ? 173 THR A N 1 ATOM 1307 C CA . THR A 1 173 ? 9.435 -6.001 -3.238 1.00 24.23 ? 173 THR A CA 1 ATOM 1308 C C . THR A 1 173 ? 8.948 -5.724 -1.823 1.00 23.36 ? 173 THR A C 1 ATOM 1309 O O . THR A 1 173 ? 7.751 -5.746 -1.539 1.00 22.64 ? 173 THR A O 1 ATOM 1310 C CB . THR A 1 173 ? 9.753 -4.653 -3.932 1.00 24.77 ? 173 THR A CB 1 ATOM 1311 O OG1 . THR A 1 173 ? 8.543 -3.913 -4.183 1.00 22.63 ? 173 THR A OG1 1 ATOM 1312 C CG2 . THR A 1 173 ? 10.362 -4.899 -5.321 1.00 24.91 ? 173 THR A CG2 1 ATOM 1313 N N . LYS A 1 174 ? 9.902 -5.452 -0.942 1.00 21.70 ? 174 LYS A N 1 ATOM 1314 C CA . LYS A 1 174 ? 9.605 -5.093 0.430 1.00 21.21 ? 174 LYS A CA 1 ATOM 1315 C C . LYS A 1 174 ? 10.225 -3.740 0.766 1.00 20.47 ? 174 LYS A C 1 ATOM 1316 O O . LYS A 1 174 ? 9.551 -2.819 1.183 1.00 19.60 ? 174 LYS A O 1 ATOM 1317 C CB . LYS A 1 174 ? 10.152 -6.143 1.405 1.00 21.78 ? 174 LYS A CB 1 ATOM 1318 C CG . LYS A 1 174 ? 9.651 -5.943 2.837 1.00 24.22 ? 174 LYS A CG 1 ATOM 1319 C CD . LYS A 1 174 ? 9.737 -7.207 3.643 1.00 24.40 ? 174 LYS A CD 1 ATOM 1320 C CE . LYS A 1 174 ? 11.181 -7.571 3.941 1.00 26.45 ? 174 LYS A CE 1 ATOM 1321 N NZ . LYS A 1 174 ? 11.226 -9.035 4.253 1.00 26.83 ? 174 LYS A NZ 1 ATOM 1322 N N . GLU A 1 175 ? 11.543 -3.606 0.603 1.00 19.56 ? 175 GLU A N 1 ATOM 1323 C CA . GLU A 1 175 ? 12.149 -2.352 0.987 1.00 18.81 ? 175 GLU A CA 1 ATOM 1324 C C . GLU A 1 175 ? 13.396 -2.096 0.142 1.00 18.86 ? 175 GLU A C 1 ATOM 1325 O O . GLU A 1 175 ? 13.960 -3.001 -0.454 1.00 19.97 ? 175 GLU A O 1 ATOM 1326 C CB . GLU A 1 175 ? 12.591 -2.433 2.477 1.00 18.08 ? 175 GLU A CB 1 ATOM 1327 C CG . GLU A 1 175 ? 11.436 -2.624 3.458 1.00 19.51 ? 175 GLU A CG 1 ATOM 1328 C CD . GLU A 1 175 ? 11.834 -2.668 4.932 1.00 20.31 ? 175 GLU A CD 1 ATOM 1329 O OE1 . GLU A 1 175 ? 12.945 -2.210 5.299 1.00 19.78 ? 175 GLU A OE1 1 ATOM 1330 O OE2 . GLU A 1 175 ? 11.010 -3.144 5.747 1.00 16.13 ? 175 GLU A OE2 1 ATOM 1331 N N . PHE A 1 176 ? 13.881 -0.877 0.104 1.00 17.64 ? 176 PHE A N 1 ATOM 1332 C CA . PHE A 1 176 ? 15.183 -0.700 -0.487 1.00 17.67 ? 176 PHE A CA 1 ATOM 1333 C C . PHE A 1 176 ? 15.944 0.393 0.238 1.00 17.58 ? 176 PHE A C 1 ATOM 1334 O O . PHE A 1 176 ? 15.337 1.231 0.917 1.00 17.09 ? 176 PHE A O 1 ATOM 1335 C CB . PHE A 1 176 ? 15.119 -0.405 -1.973 1.00 17.55 ? 176 PHE A CB 1 ATOM 1336 C CG . PHE A 1 176 ? 14.869 1.017 -2.291 1.00 17.41 ? 176 PHE A CG 1 ATOM 1337 C CD1 . PHE A 1 176 ? 15.935 1.915 -2.440 1.00 18.51 ? 176 PHE A CD1 1 ATOM 1338 C CD2 . PHE A 1 176 ? 13.582 1.467 -2.498 1.00 18.67 ? 176 PHE A CD2 1 ATOM 1339 C CE1 . PHE A 1 176 ? 15.714 3.252 -2.786 1.00 15.89 ? 176 PHE A CE1 1 ATOM 1340 C CE2 . PHE A 1 176 ? 13.342 2.807 -2.816 1.00 18.33 ? 176 PHE A CE2 1 ATOM 1341 C CZ . PHE A 1 176 ? 14.411 3.707 -2.951 1.00 16.18 ? 176 PHE A CZ 1 ATOM 1342 N N . VAL A 1 177 ? 17.266 0.377 0.073 1.00 16.51 ? 177 VAL A N 1 ATOM 1343 C CA . VAL A 1 177 ? 18.110 1.372 0.679 1.00 15.97 ? 177 VAL A CA 1 ATOM 1344 C C . VAL A 1 177 ? 19.335 1.584 -0.232 1.00 15.30 ? 177 VAL A C 1 ATOM 1345 O O . VAL A 1 177 ? 19.690 0.694 -1.042 1.00 14.84 ? 177 VAL A O 1 ATOM 1346 C CB . VAL A 1 177 ? 18.447 0.934 2.135 1.00 16.84 ? 177 VAL A CB 1 ATOM 1347 C CG1 . VAL A 1 177 ? 19.823 1.301 2.543 1.00 18.27 ? 177 VAL A CG1 1 ATOM 1348 C CG2 . VAL A 1 177 ? 17.401 1.505 3.144 1.00 18.73 ? 177 VAL A CG2 1 ATOM 1349 N N . GLY A 1 178 ? 19.921 2.785 -0.157 1.00 13.99 ? 178 GLY A N 1 ATOM 1350 C CA . GLY A 1 178 ? 21.137 3.121 -0.886 1.00 12.88 ? 178 GLY A CA 1 ATOM 1351 C C . GLY A 1 178 ? 22.200 2.111 -0.537 1.00 12.81 ? 178 GLY A C 1 ATOM 1352 O O . GLY A 1 178 ? 22.110 1.446 0.492 1.00 12.57 ? 178 GLY A O 1 ATOM 1353 N N . GLY A 1 179 ? 23.243 1.999 -1.350 1.00 12.38 ? 179 GLY A N 1 ATOM 1354 C CA . GLY A 1 179 ? 24.267 0.999 -1.094 1.00 11.78 ? 179 GLY A CA 1 ATOM 1355 C C . GLY A 1 179 ? 25.299 1.335 -0.031 1.00 12.04 ? 179 GLY A C 1 ATOM 1356 O O . GLY A 1 179 ? 26.094 0.495 0.339 1.00 11.76 ? 179 GLY A O 1 ATOM 1357 N N . VAL A 1 180 ? 25.235 2.570 0.456 1.00 12.24 ? 180 VAL A N 1 ATOM 1358 C CA . VAL A 1 180 ? 26.078 3.094 1.521 1.00 12.03 ? 180 VAL A CA 1 ATOM 1359 C C . VAL A 1 180 ? 27.316 3.713 1.011 1.00 11.95 ? 180 VAL A C 1 ATOM 1360 O O . VAL A 1 180 ? 28.154 3.072 0.350 1.00 12.77 ? 180 VAL A O 1 ATOM 1361 C CB . VAL A 1 180 ? 26.364 2.079 2.631 1.00 13.35 ? 180 VAL A CB 1 ATOM 1362 C CG1 . VAL A 1 180 ? 27.346 2.674 3.682 1.00 14.08 ? 180 VAL A CG1 1 ATOM 1363 C CG2 . VAL A 1 180 ? 25.032 1.654 3.311 1.00 11.73 ? 180 VAL A CG2 1 ATOM 1364 N N . GLY A 1 181 ? 27.454 4.995 1.303 1.00 11.73 ? 181 GLY A N 1 ATOM 1365 C CA . GLY A 1 181 ? 28.745 5.623 0.999 1.00 11.23 ? 181 GLY A CA 1 ATOM 1366 C C . GLY A 1 181 ? 28.579 6.577 -0.152 1.00 11.73 ? 181 GLY A C 1 ATOM 1367 O O . GLY A 1 181 ? 27.422 6.999 -0.468 1.00 13.22 ? 181 GLY A O 1 ATOM 1368 N N . ALA A 1 182 ? 29.696 6.896 -0.786 1.00 11.08 ? 182 ALA A N 1 ATOM 1369 C CA . ALA A 1 182 ? 29.733 7.849 -1.871 1.00 10.86 ? 182 ALA A CA 1 ATOM 1370 C C . ALA A 1 182 ? 29.378 7.186 -3.194 1.00 10.71 ? 182 ALA A C 1 ATOM 1371 O O . ALA A 1 182 ? 29.995 6.196 -3.608 1.00 9.56 ? 182 ALA A O 1 ATOM 1372 C CB . ALA A 1 182 ? 31.148 8.509 -1.963 1.00 11.03 ? 182 ALA A CB 1 ATOM 1373 N N . ALA A 1 183 ? 28.403 7.781 -3.873 1.00 11.36 ? 183 ALA A N 1 ATOM 1374 C CA . ALA A 1 183 ? 27.967 7.305 -5.176 1.00 11.39 ? 183 ALA A CA 1 ATOM 1375 C C . ALA A 1 183 ? 28.350 8.404 -6.147 1.00 11.44 ? 183 ALA A C 1 ATOM 1376 O O . ALA A 1 183 ? 29.232 9.195 -5.807 1.00 12.29 ? 183 ALA A O 1 ATOM 1377 C CB . ALA A 1 183 ? 26.463 7.025 -5.176 1.00 11.67 ? 183 ALA A CB 1 ATOM 1378 N N . ILE A 1 184 ? 27.707 8.514 -7.320 1.00 11.15 ? 184 ILE A N 1 ATOM 1379 C CA . ILE A 1 184 ? 28.247 9.444 -8.336 1.00 10.82 ? 184 ILE A CA 1 ATOM 1380 C C . ILE A 1 184 ? 27.272 10.211 -9.206 1.00 11.34 ? 184 ILE A C 1 ATOM 1381 O O . ILE A 1 184 ? 26.100 9.891 -9.307 1.00 10.32 ? 184 ILE A O 1 ATOM 1382 C CB . ILE A 1 184 ? 29.099 8.635 -9.356 1.00 11.44 ? 184 ILE A CB 1 ATOM 1383 C CG1 . ILE A 1 184 ? 28.188 7.680 -10.175 1.00 9.63 ? 184 ILE A CG1 1 ATOM 1384 C CG2 . ILE A 1 184 ? 30.173 7.761 -8.652 1.00 12.24 ? 184 ILE A CG2 1 ATOM 1385 C CD1 . ILE A 1 184 ? 28.954 6.855 -11.233 1.00 9.67 ? 184 ILE A CD1 1 ATOM 1386 N N . VAL A 1 185 ? 27.826 11.225 -9.865 1.00 12.87 ? 185 VAL A N 1 ATOM 1387 C CA . VAL A 1 185 ? 27.221 11.811 -11.046 1.00 13.19 ? 185 VAL A CA 1 ATOM 1388 C C . VAL A 1 185 ? 27.958 11.169 -12.199 1.00 13.58 ? 185 VAL A C 1 ATOM 1389 O O . VAL A 1 185 ? 29.175 11.180 -12.222 1.00 14.31 ? 185 VAL A O 1 ATOM 1390 C CB . VAL A 1 185 ? 27.479 13.329 -11.171 1.00 14.06 ? 185 VAL A CB 1 ATOM 1391 C CG1 . VAL A 1 185 ? 26.855 13.840 -12.459 1.00 10.53 ? 185 VAL A CG1 1 ATOM 1392 C CG2 . VAL A 1 185 ? 26.873 14.087 -9.968 1.00 12.75 ? 185 VAL A CG2 1 ATOM 1393 N N . GLY A 1 186 ? 27.234 10.554 -13.121 1.00 14.51 ? 186 GLY A N 1 ATOM 1394 C CA . GLY A 1 186 ? 27.825 9.951 -14.325 1.00 13.75 ? 186 GLY A CA 1 ATOM 1395 C C . GLY A 1 186 ? 28.352 11.035 -15.276 1.00 13.68 ? 186 GLY A C 1 ATOM 1396 O O . GLY A 1 186 ? 27.998 12.203 -15.153 1.00 12.51 ? 186 GLY A O 1 ATOM 1397 N N . SER A 1 187 ? 29.179 10.660 -16.244 1.00 13.03 ? 187 SER A N 1 ATOM 1398 C CA . SER A 1 187 ? 29.698 11.658 -17.163 1.00 14.84 ? 187 SER A CA 1 ATOM 1399 C C . SER A 1 187 ? 28.550 12.268 -17.961 1.00 15.22 ? 187 SER A C 1 ATOM 1400 O O . SER A 1 187 ? 28.684 13.396 -18.454 1.00 13.97 ? 187 SER A O 1 ATOM 1401 C CB . SER A 1 187 ? 30.761 11.091 -18.124 1.00 14.75 ? 187 SER A CB 1 ATOM 1402 O OG . SER A 1 187 ? 30.200 10.036 -18.906 1.00 19.42 ? 187 SER A OG 1 ATOM 1403 N N . ASN A 1 188 ? 27.431 11.539 -18.103 1.00 15.13 ? 188 ASN A N 1 ATOM 1404 C CA . ASN A 1 188 ? 26.279 12.137 -18.792 1.00 14.85 ? 188 ASN A CA 1 ATOM 1405 C C . ASN A 1 188 ? 25.437 12.998 -17.862 1.00 14.60 ? 188 ASN A C 1 ATOM 1406 O O . ASN A 1 188 ? 24.356 13.465 -18.253 1.00 14.64 ? 188 ASN A O 1 ATOM 1407 C CB . ASN A 1 188 ? 25.396 11.106 -19.466 1.00 14.31 ? 188 ASN A CB 1 ATOM 1408 C CG . ASN A 1 188 ? 24.636 10.224 -18.465 1.00 15.69 ? 188 ASN A CG 1 ATOM 1409 O OD1 . ASN A 1 188 ? 24.665 10.467 -17.253 1.00 13.60 ? 188 ASN A OD1 1 ATOM 1410 N ND2 . ASN A 1 188 ? 23.958 9.177 -18.987 1.00 11.59 ? 188 ASN A ND2 1 ATOM 1411 N N . GLY A 1 189 ? 25.929 13.208 -16.641 1.00 13.96 ? 189 GLY A N 1 ATOM 1412 C CA . GLY A 1 189 ? 25.228 14.059 -15.685 1.00 13.22 ? 189 GLY A CA 1 ATOM 1413 C C . GLY A 1 189 ? 24.144 13.363 -14.840 1.00 13.52 ? 189 GLY A C 1 ATOM 1414 O O . GLY A 1 189 ? 23.584 13.985 -13.924 1.00 10.81 ? 189 GLY A O 1 ATOM 1415 N N . ASN A 1 190 ? 23.828 12.094 -15.145 1.00 13.13 ? 190 ASN A N 1 ATOM 1416 C CA . ASN A 1 190 ? 22.882 11.330 -14.305 1.00 12.39 ? 190 ASN A CA 1 ATOM 1417 C C . ASN A 1 190 ? 23.323 11.219 -12.849 1.00 12.90 ? 190 ASN A C 1 ATOM 1418 O O . ASN A 1 190 ? 24.528 11.049 -12.562 1.00 13.17 ? 190 ASN A O 1 ATOM 1419 C CB . ASN A 1 190 ? 22.718 9.892 -14.822 1.00 11.88 ? 190 ASN A CB 1 ATOM 1420 C CG . ASN A 1 190 ? 21.896 9.823 -16.078 1.00 12.76 ? 190 ASN A CG 1 ATOM 1421 O OD1 . ASN A 1 190 ? 21.439 10.850 -16.584 1.00 13.95 ? 190 ASN A OD1 1 ATOM 1422 N ND2 . ASN A 1 190 ? 21.692 8.616 -16.592 1.00 9.92 ? 190 ASN A ND2 1 ATOM 1423 N N . LEU A 1 191 ? 22.351 11.288 -11.936 1.00 13.12 ? 191 LEU A N 1 ATOM 1424 C CA . LEU A 1 191 ? 22.612 11.008 -10.539 1.00 13.81 ? 191 LEU A CA 1 ATOM 1425 C C . LEU A 1 191 ? 22.556 9.476 -10.471 1.00 13.27 ? 191 LEU A C 1 ATOM 1426 O O . LEU A 1 191 ? 21.593 8.880 -10.950 1.00 13.64 ? 191 LEU A O 1 ATOM 1427 C CB . LEU A 1 191 ? 21.559 11.637 -9.632 1.00 12.44 ? 191 LEU A CB 1 ATOM 1428 C CG . LEU A 1 191 ? 21.472 13.173 -9.593 1.00 14.52 ? 191 LEU A CG 1 ATOM 1429 C CD1 . LEU A 1 191 ? 20.470 13.669 -8.505 1.00 12.70 ? 191 LEU A CD1 1 ATOM 1430 C CD2 . LEU A 1 191 ? 22.832 13.858 -9.403 1.00 13.98 ? 191 LEU A CD2 1 ATOM 1431 N N . VAL A 1 192 ? 23.586 8.830 -9.940 1.00 12.34 ? 192 VAL A N 1 ATOM 1432 C CA . VAL A 1 192 ? 23.550 7.355 -9.899 1.00 12.85 ? 192 VAL A CA 1 ATOM 1433 C C . VAL A 1 192 ? 23.738 6.711 -8.531 1.00 12.59 ? 192 VAL A C 1 ATOM 1434 O O . VAL A 1 192 ? 24.788 6.781 -7.928 1.00 13.48 ? 192 VAL A O 1 ATOM 1435 C CB . VAL A 1 192 ? 24.555 6.739 -10.874 1.00 12.83 ? 192 VAL A CB 1 ATOM 1436 C CG1 . VAL A 1 192 ? 24.471 5.233 -10.859 1.00 10.85 ? 192 VAL A CG1 1 ATOM 1437 C CG2 . VAL A 1 192 ? 24.298 7.285 -12.274 1.00 12.37 ? 192 VAL A CG2 1 ATOM 1438 N N . TYR A 1 193 ? 22.681 6.103 -8.053 1.00 12.31 ? 193 TYR A N 1 ATOM 1439 C CA . TYR A 1 193 ? 22.658 5.425 -6.774 1.00 11.85 ? 193 TYR A CA 1 ATOM 1440 C C . TYR A 1 193 ? 22.598 3.936 -7.002 1.00 11.53 ? 193 TYR A C 1 ATOM 1441 O O . TYR A 1 193 ? 21.684 3.431 -7.672 1.00 11.44 ? 193 TYR A O 1 ATOM 1442 C CB . TYR A 1 193 ? 21.368 5.771 -5.982 1.00 11.77 ? 193 TYR A CB 1 ATOM 1443 C CG . TYR A 1 193 ? 21.413 7.024 -5.131 1.00 11.25 ? 193 TYR A CG 1 ATOM 1444 C CD1 . TYR A 1 193 ? 20.380 7.938 -5.192 1.00 7.78 ? 193 TYR A CD1 1 ATOM 1445 C CD2 . TYR A 1 193 ? 22.482 7.293 -4.281 1.00 8.38 ? 193 TYR A CD2 1 ATOM 1446 C CE1 . TYR A 1 193 ? 20.392 9.081 -4.438 1.00 8.94 ? 193 TYR A CE1 1 ATOM 1447 C CE2 . TYR A 1 193 ? 22.513 8.471 -3.494 1.00 9.44 ? 193 TYR A CE2 1 ATOM 1448 C CZ . TYR A 1 193 ? 21.440 9.351 -3.586 1.00 10.80 ? 193 TYR A CZ 1 ATOM 1449 O OH . TYR A 1 193 ? 21.404 10.526 -2.874 1.00 11.10 ? 193 TYR A OH 1 ATOM 1450 N N . PRO A 1 194 ? 23.548 3.227 -6.413 1.00 11.55 ? 194 PRO A N 1 ATOM 1451 C CA . PRO A 1 194 ? 23.485 1.773 -6.383 1.00 11.00 ? 194 PRO A CA 1 ATOM 1452 C C . PRO A 1 194 ? 22.575 1.551 -5.201 1.00 11.37 ? 194 PRO A C 1 ATOM 1453 O O . PRO A 1 194 ? 22.700 2.265 -4.191 1.00 11.09 ? 194 PRO A O 1 ATOM 1454 C CB . PRO A 1 194 ? 24.896 1.362 -6.017 1.00 10.40 ? 194 PRO A CB 1 ATOM 1455 C CG . PRO A 1 194 ? 25.432 2.485 -5.209 1.00 10.86 ? 194 PRO A CG 1 ATOM 1456 C CD . PRO A 1 194 ? 24.715 3.759 -5.686 1.00 11.27 ? 194 PRO A CD 1 ATOM 1457 N N . VAL A 1 195 ? 21.649 0.617 -5.312 1.00 11.85 ? 195 VAL A N 1 ATOM 1458 C CA . VAL A 1 195 ? 20.745 0.371 -4.196 1.00 12.06 ? 195 VAL A CA 1 ATOM 1459 C C . VAL A 1 195 ? 20.657 -1.120 -3.846 1.00 12.53 ? 195 VAL A C 1 ATOM 1460 O O . VAL A 1 195 ? 20.983 -1.985 -4.666 1.00 12.02 ? 195 VAL A O 1 ATOM 1461 C CB . VAL A 1 195 ? 19.340 0.911 -4.519 1.00 13.01 ? 195 VAL A CB 1 ATOM 1462 C CG1 . VAL A 1 195 ? 19.360 2.443 -4.730 1.00 9.24 ? 195 VAL A CG1 1 ATOM 1463 C CG2 . VAL A 1 195 ? 18.741 0.171 -5.754 1.00 13.55 ? 195 VAL A CG2 1 ATOM 1464 N N . GLN A 1 196 ? 20.229 -1.412 -2.623 1.00 13.50 ? 196 GLN A N 1 ATOM 1465 C CA . GLN A 1 196 ? 20.065 -2.787 -2.184 1.00 14.88 ? 196 GLN A CA 1 ATOM 1466 C C . GLN A 1 196 ? 18.583 -2.972 -1.916 1.00 16.64 ? 196 GLN A C 1 ATOM 1467 O O . GLN A 1 196 ? 17.955 -2.150 -1.273 1.00 17.26 ? 196 GLN A O 1 ATOM 1468 C CB . GLN A 1 196 ? 20.917 -3.097 -0.946 1.00 15.15 ? 196 GLN A CB 1 ATOM 1469 C CG . GLN A 1 196 ? 20.993 -1.986 0.088 1.00 14.27 ? 196 GLN A CG 1 ATOM 1470 C CD . GLN A 1 196 ? 22.008 -2.225 1.205 1.00 13.30 ? 196 GLN A CD 1 ATOM 1471 O OE1 . GLN A 1 196 ? 22.395 -1.282 1.895 1.00 15.73 ? 196 GLN A OE1 1 ATOM 1472 N NE2 . GLN A 1 196 ? 22.384 -3.478 1.420 1.00 8.14 ? 196 GLN A NE2 1 ATOM 1473 N N . ILE A 1 197 ? 18.032 -4.045 -2.463 1.00 17.70 ? 197 ILE A N 1 ATOM 1474 C CA . ILE A 1 197 ? 16.631 -4.354 -2.367 1.00 17.61 ? 197 ILE A CA 1 ATOM 1475 C C . ILE A 1 197 ? 16.398 -5.662 -1.620 1.00 18.91 ? 197 ILE A C 1 ATOM 1476 O O . ILE A 1 197 ? 17.056 -6.668 -1.891 1.00 18.13 ? 197 ILE A O 1 ATOM 1477 C CB . ILE A 1 197 ? 16.053 -4.623 -3.765 1.00 17.14 ? 197 ILE A CB 1 ATOM 1478 C CG1 . ILE A 1 197 ? 16.536 -3.636 -4.816 1.00 16.60 ? 197 ILE A CG1 1 ATOM 1479 C CG2 . ILE A 1 197 ? 14.528 -4.820 -3.688 1.00 14.24 ? 197 ILE A CG2 1 ATOM 1480 C CD1 . ILE A 1 197 ? 15.834 -2.336 -4.848 1.00 17.80 ? 197 ILE A CD1 1 ATOM 1481 N N . ALA A 1 198 ? 15.397 -5.662 -0.742 1.00 20.42 ? 198 ALA A N 1 ATOM 1482 C CA . ALA A 1 198 ? 14.962 -6.881 -0.047 1.00 21.06 ? 198 ALA A CA 1 ATOM 1483 C C . ALA A 1 198 ? 13.617 -7.264 -0.623 1.00 21.87 ? 198 ALA A C 1 ATOM 1484 O O . ALA A 1 198 ? 12.708 -6.434 -0.659 1.00 20.34 ? 198 ALA A O 1 ATOM 1485 C CB . ALA A 1 198 ? 14.788 -6.609 1.435 1.00 20.87 ? 198 ALA A CB 1 ATOM 1486 N N . ASP A 1 199 ? 13.475 -8.511 -1.049 1.00 23.91 ? 199 ASP A N 1 ATOM 1487 C CA . ASP A 1 199 ? 12.187 -8.982 -1.546 1.00 25.99 ? 199 ASP A CA 1 ATOM 1488 C C . ASP A 1 199 ? 11.345 -9.557 -0.391 1.00 27.27 ? 199 ASP A C 1 ATOM 1489 O O . ASP A 1 199 ? 11.815 -9.637 0.743 1.00 27.06 ? 199 ASP A O 1 ATOM 1490 C CB . ASP A 1 199 ? 12.354 -9.992 -2.686 1.00 25.82 ? 199 ASP A CB 1 ATOM 1491 C CG . ASP A 1 199 ? 12.809 -11.335 -2.214 1.00 25.99 ? 199 ASP A CG 1 ATOM 1492 O OD1 . ASP A 1 199 ? 12.903 -11.535 -1.006 1.00 25.71 ? 199 ASP A OD1 1 ATOM 1493 O OD2 . ASP A 1 199 ? 13.107 -12.268 -2.991 1.00 29.93 ? 199 ASP A OD2 1 ATOM 1494 N N . MET A 1 200 ? 10.108 -9.948 -0.679 1.00 28.56 ? 200 MET A N 1 ATOM 1495 C CA . MET A 1 200 ? 9.205 -10.396 0.377 1.00 30.44 ? 200 MET A CA 1 ATOM 1496 C C . MET A 1 200 ? 9.772 -11.594 1.153 1.00 31.73 ? 200 MET A C 1 ATOM 1497 O O . MET A 1 200 ? 9.573 -11.698 2.363 1.00 32.65 ? 200 MET A O 1 ATOM 1498 C CB . MET A 1 200 ? 7.791 -10.643 -0.165 1.00 30.23 ? 200 MET A CB 1 ATOM 1499 C CG . MET A 1 200 ? 6.995 -9.353 -0.413 1.00 30.67 ? 200 MET A CG 1 ATOM 1500 S SD . MET A 1 200 ? 6.895 -8.296 1.060 1.00 31.04 ? 200 MET A SD 1 ATOM 1501 C CE . MET A 1 200 ? 5.943 -9.327 2.152 1.00 33.64 ? 200 MET A CE 1 ATOM 1502 N N . GLY A 1 201 ? 10.549 -12.447 0.477 1.00 31.89 ? 201 GLY A N 1 ATOM 1503 C CA . GLY A 1 201 ? 11.120 -13.627 1.114 1.00 31.41 ? 201 GLY A CA 1 ATOM 1504 C C . GLY A 1 201 ? 12.426 -13.382 1.843 1.00 31.24 ? 201 GLY A C 1 ATOM 1505 O O . GLY A 1 201 ? 13.156 -14.318 2.208 1.00 31.74 ? 201 GLY A O 1 ATOM 1506 N N . GLY A 1 202 ? 12.770 -12.115 2.033 1.00 29.83 ? 202 GLY A N 1 ATOM 1507 C CA . GLY A 1 202 ? 14.018 -11.788 2.707 1.00 28.16 ? 202 GLY A CA 1 ATOM 1508 C C . GLY A 1 202 ? 15.292 -11.904 1.870 1.00 27.43 ? 202 GLY A C 1 ATOM 1509 O O . GLY A 1 202 ? 16.389 -11.828 2.424 1.00 27.55 ? 202 GLY A O 1 ATOM 1510 N N . ARG A 1 203 ? 15.171 -12.096 0.555 1.00 25.80 ? 203 ARG A N 1 ATOM 1511 C CA . ARG A 1 203 ? 16.360 -12.162 -0.297 1.00 24.55 ? 203 ARG A CA 1 ATOM 1512 C C . ARG A 1 203 ? 16.870 -10.762 -0.523 1.00 22.77 ? 203 ARG A C 1 ATOM 1513 O O . ARG A 1 203 ? 16.088 -9.833 -0.542 1.00 23.05 ? 203 ARG A O 1 ATOM 1514 C CB . ARG A 1 203 ? 16.054 -12.819 -1.644 1.00 24.96 ? 203 ARG A CB 1 ATOM 1515 C CG . ARG A 1 203 ? 15.561 -14.256 -1.532 1.00 26.17 ? 203 ARG A CG 1 ATOM 1516 C CD . ARG A 1 203 ? 15.389 -14.947 -2.862 1.00 28.41 ? 203 ARG A CD 1 ATOM 1517 N NE . ARG A 1 203 ? 14.228 -14.430 -3.593 1.00 30.97 ? 203 ARG A NE 1 ATOM 1518 C CZ . ARG A 1 203 ? 13.770 -14.968 -4.723 1.00 31.31 ? 203 ARG A CZ 1 ATOM 1519 N NH1 . ARG A 1 203 ? 14.394 -16.022 -5.241 1.00 31.27 ? 203 ARG A NH1 1 ATOM 1520 N NH2 . ARG A 1 203 ? 12.708 -14.451 -5.342 1.00 29.44 ? 203 ARG A NH2 1 ATOM 1521 N N . VAL A 1 204 ? 18.183 -10.594 -0.659 1.00 20.88 ? 204 VAL A N 1 ATOM 1522 C CA . VAL A 1 204 ? 18.731 -9.262 -0.927 1.00 18.52 ? 204 VAL A CA 1 ATOM 1523 C C . VAL A 1 204 ? 19.399 -9.248 -2.293 1.00 16.89 ? 204 VAL A C 1 ATOM 1524 O O . VAL A 1 204 ? 19.941 -10.263 -2.719 1.00 16.59 ? 204 VAL A O 1 ATOM 1525 C CB . VAL A 1 204 ? 19.698 -8.767 0.201 1.00 19.26 ? 204 VAL A CB 1 ATOM 1526 C CG1 . VAL A 1 204 ? 20.946 -9.672 0.344 1.00 19.49 ? 204 VAL A CG1 1 ATOM 1527 C CG2 . VAL A 1 204 ? 20.150 -7.300 -0.035 1.00 20.30 ? 204 VAL A CG2 1 ATOM 1528 N N . PHE A 1 205 ? 19.317 -8.131 -3.013 1.00 14.37 ? 205 PHE A N 1 ATOM 1529 C CA . PHE A 1 205 ? 19.992 -8.049 -4.302 1.00 13.49 ? 205 PHE A CA 1 ATOM 1530 C C . PHE A 1 205 ? 20.186 -6.585 -4.646 1.00 13.06 ? 205 PHE A C 1 ATOM 1531 O O . PHE A 1 205 ? 19.609 -5.709 -4.001 1.00 13.53 ? 205 PHE A O 1 ATOM 1532 C CB . PHE A 1 205 ? 19.212 -8.795 -5.390 1.00 14.05 ? 205 PHE A CB 1 ATOM 1533 C CG . PHE A 1 205 ? 17.808 -8.264 -5.608 1.00 14.32 ? 205 PHE A CG 1 ATOM 1534 C CD1 . PHE A 1 205 ? 17.550 -7.330 -6.592 1.00 14.67 ? 205 PHE A CD1 1 ATOM 1535 C CD2 . PHE A 1 205 ? 16.769 -8.687 -4.809 1.00 13.69 ? 205 PHE A CD2 1 ATOM 1536 C CE1 . PHE A 1 205 ? 16.269 -6.830 -6.794 1.00 15.83 ? 205 PHE A CE1 1 ATOM 1537 C CE2 . PHE A 1 205 ? 15.491 -8.207 -5.008 1.00 15.96 ? 205 PHE A CE2 1 ATOM 1538 C CZ . PHE A 1 205 ? 15.244 -7.274 -6.009 1.00 16.68 ? 205 PHE A CZ 1 ATOM 1539 N N . THR A 1 206 ? 21.018 -6.285 -5.634 1.00 12.30 ? 206 THR A N 1 ATOM 1540 C CA . THR A 1 206 ? 21.252 -4.893 -5.924 1.00 11.52 ? 206 THR A CA 1 ATOM 1541 C C . THR A 1 206 ? 20.842 -4.464 -7.317 1.00 12.07 ? 206 THR A C 1 ATOM 1542 O O . THR A 1 206 ? 20.752 -5.277 -8.210 1.00 11.95 ? 206 THR A O 1 ATOM 1543 C CB . THR A 1 206 ? 22.703 -4.506 -5.619 1.00 11.23 ? 206 THR A CB 1 ATOM 1544 O OG1 . THR A 1 206 ? 23.592 -5.183 -6.528 1.00 8.23 ? 206 THR A OG1 1 ATOM 1545 C CG2 . THR A 1 206 ? 23.056 -5.022 -4.229 1.00 9.75 ? 206 THR A CG2 1 ATOM 1546 N N . LYS A 1 207 ? 20.627 -3.160 -7.460 1.00 13.01 ? 207 LYS A N 1 ATOM 1547 C CA . LYS A 1 207 ? 20.148 -2.526 -8.703 1.00 14.08 ? 207 LYS A CA 1 ATOM 1548 C C . LYS A 1 207 ? 20.696 -1.112 -8.762 1.00 13.49 ? 207 LYS A C 1 ATOM 1549 O O . LYS A 1 207 ? 21.237 -0.601 -7.762 1.00 14.12 ? 207 LYS A O 1 ATOM 1550 C CB . LYS A 1 207 ? 18.606 -2.402 -8.695 1.00 13.54 ? 207 LYS A CB 1 ATOM 1551 C CG . LYS A 1 207 ? 17.873 -3.596 -9.218 1.00 16.58 ? 207 LYS A CG 1 ATOM 1552 C CD . LYS A 1 207 ? 16.432 -3.226 -9.673 1.00 18.15 ? 207 LYS A CD 1 ATOM 1553 C CE . LYS A 1 207 ? 15.876 -4.362 -10.495 1.00 18.38 ? 207 LYS A CE 1 ATOM 1554 N NZ . LYS A 1 207 ? 16.497 -4.384 -11.861 1.00 18.67 ? 207 LYS A NZ 1 ATOM 1555 N N . ILE A 1 208 ? 20.543 -0.485 -9.925 1.00 13.58 ? 208 ILE A N 1 ATOM 1556 C CA . ILE A 1 208 ? 20.914 0.914 -10.108 1.00 13.67 ? 208 ILE A CA 1 ATOM 1557 C C . ILE A 1 208 ? 19.650 1.769 -10.049 1.00 14.49 ? 208 ILE A C 1 ATOM 1558 O O . ILE A 1 208 ? 18.666 1.462 -10.747 1.00 15.49 ? 208 ILE A O 1 ATOM 1559 C CB . ILE A 1 208 ? 21.568 1.141 -11.469 1.00 13.07 ? 208 ILE A CB 1 ATOM 1560 C CG1 . ILE A 1 208 ? 22.974 0.523 -11.546 1.00 12.73 ? 208 ILE A CG1 1 ATOM 1561 C CG2 . ILE A 1 208 ? 21.623 2.598 -11.771 1.00 12.07 ? 208 ILE A CG2 1 ATOM 1562 C CD1 . ILE A 1 208 ? 23.947 0.958 -10.355 1.00 11.07 ? 208 ILE A CD1 1 ATOM 1563 N N . MET A 1 209 ? 19.655 2.836 -9.238 1.00 14.55 ? 209 MET A N 1 ATOM 1564 C CA . MET A 1 209 ? 18.522 3.776 -9.244 1.00 13.94 ? 209 MET A CA 1 ATOM 1565 C C . MET A 1 209 ? 19.092 5.112 -9.683 1.00 14.00 ? 209 MET A C 1 ATOM 1566 O O . MET A 1 209 ? 20.040 5.595 -9.086 1.00 13.57 ? 209 MET A O 1 ATOM 1567 C CB . MET A 1 209 ? 17.853 3.883 -7.873 1.00 13.11 ? 209 MET A CB 1 ATOM 1568 C CG . MET A 1 209 ? 16.626 4.800 -7.887 1.00 15.08 ? 209 MET A CG 1 ATOM 1569 S SD . MET A 1 209 ? 15.894 4.993 -6.219 1.00 16.30 ? 209 MET A SD 1 ATOM 1570 C CE . MET A 1 209 ? 17.169 6.053 -5.500 1.00 12.61 ? 209 MET A CE 1 ATOM 1571 N N . TYR A 1 210 ? 18.534 5.723 -10.731 1.00 14.57 ? 210 TYR A N 1 ATOM 1572 C CA . TYR A 1 210 ? 19.171 6.925 -11.266 1.00 15.00 ? 210 TYR A CA 1 ATOM 1573 C C . TYR A 1 210 ? 18.225 8.043 -11.713 1.00 15.56 ? 210 TYR A C 1 ATOM 1574 O O . TYR A 1 210 ? 17.047 7.807 -12.019 1.00 15.35 ? 210 TYR A O 1 ATOM 1575 C CB . TYR A 1 210 ? 20.059 6.527 -12.453 1.00 14.98 ? 210 TYR A CB 1 ATOM 1576 C CG . TYR A 1 210 ? 19.291 6.066 -13.677 1.00 16.36 ? 210 TYR A CG 1 ATOM 1577 C CD1 . TYR A 1 210 ? 18.843 4.739 -13.789 1.00 18.09 ? 210 TYR A CD1 1 ATOM 1578 C CD2 . TYR A 1 210 ? 18.983 6.961 -14.712 1.00 18.21 ? 210 TYR A CD2 1 ATOM 1579 C CE1 . TYR A 1 210 ? 18.136 4.302 -14.888 1.00 17.71 ? 210 TYR A CE1 1 ATOM 1580 C CE2 . TYR A 1 210 ? 18.255 6.535 -15.846 1.00 18.96 ? 210 TYR A CE2 1 ATOM 1581 C CZ . TYR A 1 210 ? 17.856 5.208 -15.926 1.00 19.65 ? 210 TYR A CZ 1 ATOM 1582 O OH . TYR A 1 210 ? 17.185 4.778 -17.024 1.00 19.69 ? 210 TYR A OH 1 ATOM 1583 N N . SER A 1 211 ? 18.781 9.242 -11.810 1.00 14.59 ? 211 SER A N 1 ATOM 1584 C CA . SER A 1 211 ? 18.025 10.392 -12.238 1.00 15.45 ? 211 SER A CA 1 ATOM 1585 C C . SER A 1 211 ? 18.715 11.171 -13.381 1.00 16.05 ? 211 SER A C 1 ATOM 1586 O O . SER A 1 211 ? 19.891 11.563 -13.278 1.00 15.49 ? 211 SER A O 1 ATOM 1587 C CB . SER A 1 211 ? 17.834 11.337 -11.058 1.00 15.30 ? 211 SER A CB 1 ATOM 1588 O OG . SER A 1 211 ? 17.156 12.512 -11.454 1.00 14.29 ? 211 SER A OG 1 ATOM 1589 N N . GLU A 1 212 ? 17.963 11.413 -14.448 1.00 15.62 ? 212 GLU A N 1 ATOM 1590 C CA . GLU A 1 212 ? 18.431 12.261 -15.552 1.00 15.75 ? 212 GLU A CA 1 ATOM 1591 C C . GLU A 1 212 ? 18.056 13.687 -15.367 1.00 15.95 ? 212 GLU A C 1 ATOM 1592 O O . GLU A 1 212 ? 18.364 14.503 -16.232 1.00 16.18 ? 212 GLU A O 1 ATOM 1593 C CB . GLU A 1 212 ? 17.810 11.800 -16.859 1.00 14.72 ? 212 GLU A CB 1 ATOM 1594 C CG . GLU A 1 212 ? 17.796 10.299 -16.907 1.00 15.77 ? 212 GLU A CG 1 ATOM 1595 C CD . GLU A 1 212 ? 17.083 9.748 -18.099 1.00 13.88 ? 212 GLU A CD 1 ATOM 1596 O OE1 . GLU A 1 212 ? 16.072 10.350 -18.502 1.00 16.68 ? 212 GLU A OE1 1 ATOM 1597 O OE2 . GLU A 1 212 ? 17.578 8.728 -18.649 1.00 14.92 ? 212 GLU A OE2 1 ATOM 1598 N N . ASP A 1 213 ? 17.380 14.013 -14.265 1.00 16.57 ? 213 ASP A N 1 ATOM 1599 C CA . ASP A 1 213 ? 16.907 15.388 -14.082 1.00 18.31 ? 213 ASP A CA 1 ATOM 1600 C C . ASP A 1 213 ? 17.248 15.975 -12.713 1.00 18.74 ? 213 ASP A C 1 ATOM 1601 O O . ASP A 1 213 ? 16.403 16.601 -12.065 1.00 18.07 ? 213 ASP A O 1 ATOM 1602 C CB . ASP A 1 213 ? 15.378 15.492 -14.295 1.00 18.09 ? 213 ASP A CB 1 ATOM 1603 C CG . ASP A 1 213 ? 14.604 14.571 -13.352 1.00 20.57 ? 213 ASP A CG 1 ATOM 1604 O OD1 . ASP A 1 213 ? 13.415 14.263 -13.592 1.00 18.65 ? 213 ASP A OD1 1 ATOM 1605 O OD2 . ASP A 1 213 ? 15.144 14.055 -12.355 1.00 23.11 ? 213 ASP A OD2 1 ATOM 1606 N N . ASP A 1 214 ? 18.463 15.749 -12.264 1.00 19.25 ? 214 ASP A N 1 ATOM 1607 C CA . ASP A 1 214 ? 18.890 16.319 -11.008 1.00 20.52 ? 214 ASP A CA 1 ATOM 1608 C C . ASP A 1 214 ? 18.003 15.993 -9.818 1.00 20.94 ? 214 ASP A C 1 ATOM 1609 O O . ASP A 1 214 ? 17.862 16.810 -8.896 1.00 21.09 ? 214 ASP A O 1 ATOM 1610 C CB . ASP A 1 214 ? 19.094 17.828 -11.151 1.00 21.09 ? 214 ASP A CB 1 ATOM 1611 C CG . ASP A 1 214 ? 20.365 18.152 -11.959 1.00 23.11 ? 214 ASP A CG 1 ATOM 1612 O OD1 . ASP A 1 214 ? 20.553 19.276 -12.434 1.00 26.53 ? 214 ASP A OD1 1 ATOM 1613 O OD2 . ASP A 1 214 ? 21.232 17.305 -12.189 1.00 25.25 ? 214 ASP A OD2 1 ATOM 1614 N N . GLY A 1 215 ? 17.417 14.802 -9.830 1.00 20.46 ? 215 GLY A N 1 ATOM 1615 C CA . GLY A 1 215 ? 16.720 14.337 -8.651 1.00 21.57 ? 215 GLY A CA 1 ATOM 1616 C C . GLY A 1 215 ? 15.226 14.548 -8.552 1.00 22.40 ? 215 GLY A C 1 ATOM 1617 O O . GLY A 1 215 ? 14.647 14.238 -7.527 1.00 22.57 ? 215 GLY A O 1 ATOM 1618 N N . ASN A 1 216 ? 14.620 15.084 -9.607 1.00 22.82 ? 216 ASN A N 1 ATOM 1619 C CA . ASN A 1 216 ? 13.185 15.274 -9.712 1.00 23.54 ? 216 ASN A CA 1 ATOM 1620 C C . ASN A 1 216 ? 12.485 13.924 -9.930 1.00 22.88 ? 216 ASN A C 1 ATOM 1621 O O . ASN A 1 216 ? 11.464 13.659 -9.296 1.00 22.95 ? 216 ASN A O 1 ATOM 1622 C CB . ASN A 1 216 ? 12.919 16.203 -10.893 1.00 24.67 ? 216 ASN A CB 1 ATOM 1623 C CG . ASN A 1 216 ? 11.476 16.690 -10.971 1.00 29.46 ? 216 ASN A CG 1 ATOM 1624 O OD1 . ASN A 1 216 ? 11.102 17.682 -10.341 1.00 33.46 ? 216 ASN A OD1 1 ATOM 1625 N ND2 . ASN A 1 216 ? 10.667 16.014 -11.787 1.00 33.84 ? 216 ASN A ND2 1 ATOM 1626 N N . THR A 1 217 ? 13.018 13.074 -10.817 1.00 20.89 ? 217 THR A N 1 ATOM 1627 C CA . THR A 1 217 ? 12.457 11.720 -11.030 1.00 19.74 ? 217 THR A CA 1 ATOM 1628 C C . THR A 1 217 ? 13.567 10.669 -10.993 1.00 18.91 ? 217 THR A C 1 ATOM 1629 O O . THR A 1 217 ? 14.720 10.976 -11.279 1.00 18.70 ? 217 THR A O 1 ATOM 1630 C CB . THR A 1 217 ? 11.716 11.593 -12.377 1.00 19.37 ? 217 THR A CB 1 ATOM 1631 O OG1 . THR A 1 217 ? 12.586 11.987 -13.435 1.00 18.70 ? 217 THR A OG1 1 ATOM 1632 C CG2 . THR A 1 217 ? 10.582 12.608 -12.475 1.00 20.85 ? 217 THR A CG2 1 ATOM 1633 N N . TRP A 1 218 ? 13.215 9.426 -10.699 1.00 17.99 ? 218 TRP A N 1 ATOM 1634 C CA . TRP A 1 218 ? 14.186 8.384 -10.507 1.00 17.42 ? 218 TRP A CA 1 ATOM 1635 C C . TRP A 1 218 ? 13.594 7.202 -11.176 1.00 18.69 ? 218 TRP A C 1 ATOM 1636 O O . TRP A 1 218 ? 12.368 7.071 -11.210 1.00 19.09 ? 218 TRP A O 1 ATOM 1637 C CB . TRP A 1 218 ? 14.342 8.056 -9.017 1.00 17.04 ? 218 TRP A CB 1 ATOM 1638 C CG . TRP A 1 218 ? 14.924 9.156 -8.231 1.00 15.15 ? 218 TRP A CG 1 ATOM 1639 C CD1 . TRP A 1 218 ? 14.246 10.144 -7.566 1.00 15.71 ? 218 TRP A CD1 1 ATOM 1640 C CD2 . TRP A 1 218 ? 16.309 9.411 -8.018 1.00 14.80 ? 218 TRP A CD2 1 ATOM 1641 N NE1 . TRP A 1 218 ? 15.136 11.012 -6.970 1.00 14.59 ? 218 TRP A NE1 1 ATOM 1642 C CE2 . TRP A 1 218 ? 16.410 10.582 -7.235 1.00 15.01 ? 218 TRP A CE2 1 ATOM 1643 C CE3 . TRP A 1 218 ? 17.494 8.776 -8.426 1.00 16.45 ? 218 TRP A CE3 1 ATOM 1644 C CZ2 . TRP A 1 218 ? 17.639 11.125 -6.846 1.00 16.76 ? 218 TRP A CZ2 1 ATOM 1645 C CZ3 . TRP A 1 218 ? 18.710 9.325 -8.044 1.00 14.44 ? 218 TRP A CZ3 1 ATOM 1646 C CH2 . TRP A 1 218 ? 18.772 10.484 -7.261 1.00 13.77 ? 218 TRP A CH2 1 ATOM 1647 N N . LYS A 1 219 ? 14.477 6.340 -11.672 1.00 19.24 ? 219 LYS A N 1 ATOM 1648 C CA . LYS A 1 219 ? 14.145 5.122 -12.385 1.00 20.68 ? 219 LYS A CA 1 ATOM 1649 C C . LYS A 1 219 ? 15.010 3.992 -11.859 1.00 20.20 ? 219 LYS A C 1 ATOM 1650 O O . LYS A 1 219 ? 16.179 4.222 -11.524 1.00 19.64 ? 219 LYS A O 1 ATOM 1651 C CB . LYS A 1 219 ? 14.535 5.283 -13.844 1.00 21.38 ? 219 LYS A CB 1 ATOM 1652 C CG . LYS A 1 219 ? 14.523 6.726 -14.308 1.00 24.59 ? 219 LYS A CG 1 ATOM 1653 C CD . LYS A 1 219 ? 13.254 7.086 -15.058 1.00 28.38 ? 219 LYS A CD 1 ATOM 1654 C CE . LYS A 1 219 ? 13.603 7.665 -16.422 1.00 28.65 ? 219 LYS A CE 1 ATOM 1655 N NZ . LYS A 1 219 ? 14.001 6.509 -17.273 1.00 30.89 ? 219 LYS A NZ 1 ATOM 1656 N N . PHE A 1 220 ? 14.430 2.790 -11.808 1.00 19.30 ? 220 PHE A N 1 ATOM 1657 C CA . PHE A 1 220 ? 15.126 1.587 -11.404 1.00 19.30 ? 220 PHE A CA 1 ATOM 1658 C C . PHE A 1 220 ? 15.533 0.931 -12.711 1.00 19.34 ? 220 PHE A C 1 ATOM 1659 O O . PHE A 1 220 ? 14.680 0.665 -13.565 1.00 19.33 ? 220 PHE A O 1 ATOM 1660 C CB . PHE A 1 220 ? 14.224 0.682 -10.533 1.00 19.65 ? 220 PHE A CB 1 ATOM 1661 C CG . PHE A 1 220 ? 14.014 1.233 -9.128 1.00 20.32 ? 220 PHE A CG 1 ATOM 1662 C CD1 . PHE A 1 220 ? 13.027 2.179 -8.876 1.00 20.32 ? 220 PHE A CD1 1 ATOM 1663 C CD2 . PHE A 1 220 ? 14.856 0.868 -8.090 1.00 18.22 ? 220 PHE A CD2 1 ATOM 1664 C CE1 . PHE A 1 220 ? 12.869 2.716 -7.597 1.00 20.22 ? 220 PHE A CE1 1 ATOM 1665 C CE2 . PHE A 1 220 ? 14.689 1.400 -6.816 1.00 18.75 ? 220 PHE A CE2 1 ATOM 1666 C CZ . PHE A 1 220 ? 13.705 2.315 -6.575 1.00 20.05 ? 220 PHE A CZ 1 ATOM 1667 N N . ALA A 1 221 ? 16.832 0.735 -12.915 1.00 18.37 ? 221 ALA A N 1 ATOM 1668 C CA . ALA A 1 221 ? 17.248 0.163 -14.173 1.00 18.12 ? 221 ALA A CA 1 ATOM 1669 C C . ALA A 1 221 ? 16.880 -1.300 -14.151 1.00 18.31 ? 221 ALA A C 1 ATOM 1670 O O . ALA A 1 221 ? 16.646 -1.874 -13.092 1.00 18.39 ? 221 ALA A O 1 ATOM 1671 C CB . ALA A 1 221 ? 18.716 0.362 -14.418 1.00 17.85 ? 221 ALA A CB 1 ATOM 1672 N N . GLU A 1 222 ? 16.862 -1.919 -15.316 1.00 18.06 ? 222 GLU A N 1 ATOM 1673 C CA . GLU A 1 222 ? 16.375 -3.270 -15.399 1.00 18.33 ? 222 GLU A CA 1 ATOM 1674 C C . GLU A 1 222 ? 17.261 -4.361 -14.819 1.00 17.32 ? 222 GLU A C 1 ATOM 1675 O O . GLU A 1 222 ? 16.735 -5.373 -14.350 1.00 16.72 ? 222 GLU A O 1 ATOM 1676 C CB . GLU A 1 222 ? 16.038 -3.624 -16.854 1.00 18.94 ? 222 GLU A CB 1 ATOM 1677 C CG . GLU A 1 222 ? 14.704 -3.068 -17.302 1.00 22.30 ? 222 GLU A CG 1 ATOM 1678 C CD . GLU A 1 222 ? 14.517 -3.150 -18.822 1.00 27.24 ? 222 GLU A CD 1 ATOM 1679 O OE1 . GLU A 1 222 ? 14.701 -4.236 -19.421 1.00 26.51 ? 222 GLU A OE1 1 ATOM 1680 O OE2 . GLU A 1 222 ? 14.201 -2.107 -19.417 1.00 29.67 ? 222 GLU A OE2 1 ATOM 1681 N N . GLY A 1 223 ? 18.578 -4.196 -14.882 1.00 15.36 ? 223 GLY A N 1 ATOM 1682 C CA . GLY A 1 223 ? 19.437 -5.263 -14.408 1.00 15.16 ? 223 GLY A CA 1 ATOM 1683 C C . GLY A 1 223 ? 19.532 -5.384 -12.889 1.00 14.33 ? 223 GLY A C 1 ATOM 1684 O O . GLY A 1 223 ? 19.018 -4.552 -12.140 1.00 13.36 ? 223 GLY A O 1 ATOM 1685 N N . ARG A 1 224 ? 20.206 -6.431 -12.445 1.00 14.77 ? 224 ARG A N 1 ATOM 1686 C CA . ARG A 1 224 ? 20.462 -6.645 -11.017 1.00 14.95 ? 224 ARG A CA 1 ATOM 1687 C C . ARG A 1 224 ? 21.563 -7.666 -10.783 1.00 14.57 ? 224 ARG A C 1 ATOM 1688 O O . ARG A 1 224 ? 21.925 -8.429 -11.682 1.00 13.45 ? 224 ARG A O 1 ATOM 1689 C CB . ARG A 1 224 ? 19.202 -7.158 -10.313 1.00 14.86 ? 224 ARG A CB 1 ATOM 1690 C CG . ARG A 1 224 ? 18.702 -8.485 -10.835 1.00 15.20 ? 224 ARG A CG 1 ATOM 1691 C CD . ARG A 1 224 ? 17.716 -9.132 -9.878 1.00 15.18 ? 224 ARG A CD 1 ATOM 1692 N NE . ARG A 1 224 ? 17.211 -10.423 -10.326 1.00 18.26 ? 224 ARG A NE 1 ATOM 1693 C CZ . ARG A 1 224 ? 17.765 -11.608 -10.052 1.00 24.59 ? 224 ARG A CZ 1 ATOM 1694 N NH1 . ARG A 1 224 ? 18.891 -11.689 -9.331 1.00 26.49 ? 224 ARG A NH1 1 ATOM 1695 N NH2 . ARG A 1 224 ? 17.188 -12.727 -10.490 1.00 25.77 ? 224 ARG A NH2 1 ATOM 1696 N N . SER A 1 225 ? 22.057 -7.690 -9.547 1.00 14.29 ? 225 SER A N 1 ATOM 1697 C CA . SER A 1 225 ? 23.026 -8.693 -9.112 1.00 14.72 ? 225 SER A CA 1 ATOM 1698 C C . SER A 1 225 ? 22.338 -10.007 -8.826 1.00 14.92 ? 225 SER A C 1 ATOM 1699 O O . SER A 1 225 ? 21.112 -10.088 -8.789 1.00 14.85 ? 225 SER A O 1 ATOM 1700 C CB . SER A 1 225 ? 23.640 -8.278 -7.772 1.00 14.44 ? 225 SER A CB 1 ATOM 1701 O OG . SER A 1 225 ? 22.644 -8.345 -6.730 1.00 13.87 ? 225 SER A OG 1 ATOM 1702 N N . LYS A 1 226 ? 23.141 -11.033 -8.591 1.00 15.57 ? 226 LYS A N 1 ATOM 1703 C CA . LYS A 1 226 ? 22.617 -12.262 -8.035 1.00 16.61 ? 226 LYS A CA 1 ATOM 1704 C C . LYS A 1 226 ? 22.097 -11.940 -6.636 1.00 16.51 ? 226 LYS A C 1 ATOM 1705 O O . LYS A 1 226 ? 22.514 -10.954 -5.995 1.00 15.08 ? 226 LYS A O 1 ATOM 1706 C CB . LYS A 1 226 ? 23.714 -13.291 -7.828 1.00 16.81 ? 226 LYS A CB 1 ATOM 1707 C CG . LYS A 1 226 ? 24.161 -14.013 -9.069 1.00 21.99 ? 226 LYS A CG 1 ATOM 1708 C CD . LYS A 1 226 ? 25.185 -15.095 -8.712 1.00 28.07 ? 226 LYS A CD 1 ATOM 1709 C CE . LYS A 1 226 ? 25.303 -16.173 -9.796 1.00 34.06 ? 226 LYS A CE 1 ATOM 1710 N NZ . LYS A 1 226 ? 25.827 -17.474 -9.202 1.00 38.99 ? 226 LYS A NZ 1 ATOM 1711 N N . PHE A 1 227 ? 21.206 -12.806 -6.160 1.00 16.14 ? 227 PHE A N 1 ATOM 1712 C CA . PHE A 1 227 ? 20.771 -12.739 -4.779 1.00 17.04 ? 227 PHE A CA 1 ATOM 1713 C C . PHE A 1 227 ? 21.977 -12.942 -3.880 1.00 15.10 ? 227 PHE A C 1 ATOM 1714 O O . PHE A 1 227 ? 22.898 -13.652 -4.239 1.00 15.31 ? 227 PHE A O 1 ATOM 1715 C CB . PHE A 1 227 ? 19.716 -13.821 -4.492 1.00 17.17 ? 227 PHE A CB 1 ATOM 1716 C CG . PHE A 1 227 ? 18.466 -13.623 -5.260 1.00 18.66 ? 227 PHE A CG 1 ATOM 1717 C CD1 . PHE A 1 227 ? 18.086 -14.523 -6.252 1.00 20.03 ? 227 PHE A CD1 1 ATOM 1718 C CD2 . PHE A 1 227 ? 17.689 -12.507 -5.025 1.00 20.46 ? 227 PHE A CD2 1 ATOM 1719 C CE1 . PHE A 1 227 ? 16.905 -14.317 -7.004 1.00 22.08 ? 227 PHE A CE1 1 ATOM 1720 C CE2 . PHE A 1 227 ? 16.514 -12.285 -5.736 1.00 20.62 ? 227 PHE A CE2 1 ATOM 1721 C CZ . PHE A 1 227 ? 16.114 -13.208 -6.737 1.00 23.32 ? 227 PHE A CZ 1 ATOM 1722 N N . GLY A 1 228 ? 21.960 -12.319 -2.723 1.00 14.34 ? 228 GLY A N 1 ATOM 1723 C CA . GLY A 1 228 ? 23.080 -12.457 -1.799 1.00 14.39 ? 228 GLY A CA 1 ATOM 1724 C C . GLY A 1 228 ? 24.014 -11.252 -1.762 1.00 13.15 ? 228 GLY A C 1 ATOM 1725 O O . GLY A 1 228 ? 24.934 -11.235 -0.948 1.00 12.43 ? 228 GLY A O 1 ATOM 1726 N N . CYS A 1 229 ? 23.767 -10.283 -2.656 1.00 12.41 ? 229 CYS A N 1 ATOM 1727 C CA . CYS A 1 229 ? 24.547 -9.057 -2.757 1.00 11.69 ? 229 CYS A CA 1 ATOM 1728 C C . CYS A 1 229 ? 23.848 -7.951 -1.993 1.00 12.10 ? 229 CYS A C 1 ATOM 1729 O O . CYS A 1 229 ? 22.614 -7.777 -2.111 1.00 12.37 ? 229 CYS A O 1 ATOM 1730 C CB . CYS A 1 229 ? 24.695 -8.618 -4.224 1.00 10.36 ? 229 CYS A CB 1 ATOM 1731 S SG . CYS A 1 229 ? 25.705 -9.727 -5.238 1.00 11.11 ? 229 CYS A SG 1 ATOM 1732 N N . SER A 1 230 ? 24.655 -7.176 -1.272 1.00 11.85 ? 230 SER A N 1 ATOM 1733 C CA . SER A 1 230 ? 24.181 -6.057 -0.471 1.00 12.14 ? 230 SER A CA 1 ATOM 1734 C C . SER A 1 230 ? 25.214 -4.944 -0.537 1.00 11.92 ? 230 SER A C 1 ATOM 1735 O O . SER A 1 230 ? 26.273 -5.099 -1.188 1.00 12.22 ? 230 SER A O 1 ATOM 1736 C CB . SER A 1 230 ? 23.966 -6.505 0.979 1.00 11.94 ? 230 SER A CB 1 ATOM 1737 O OG . SER A 1 230 ? 25.245 -6.846 1.542 1.00 11.60 ? 230 SER A OG 1 ATOM 1738 N N . GLU A 1 231 ? 24.905 -3.832 0.132 1.00 11.40 ? 231 GLU A N 1 ATOM 1739 C CA . GLU A 1 231 ? 25.724 -2.604 0.159 1.00 10.61 ? 231 GLU A CA 1 ATOM 1740 C C . GLU A 1 231 ? 26.593 -2.381 -1.061 1.00 11.39 ? 231 GLU A C 1 ATOM 1741 O O . GLU A 1 231 ? 27.825 -2.362 -0.999 1.00 11.18 ? 231 GLU A O 1 ATOM 1742 C CB . GLU A 1 231 ? 26.520 -2.510 1.482 1.00 11.15 ? 231 GLU A CB 1 ATOM 1743 C CG . GLU A 1 231 ? 25.604 -2.330 2.706 1.00 10.15 ? 231 GLU A CG 1 ATOM 1744 C CD . GLU A 1 231 ? 26.341 -2.433 4.048 1.00 10.96 ? 231 GLU A CD 1 ATOM 1745 O OE1 . GLU A 1 231 ? 27.465 -2.948 4.077 1.00 11.44 ? 231 GLU A OE1 1 ATOM 1746 O OE2 . GLU A 1 231 ? 25.819 -1.977 5.087 1.00 8.91 ? 231 GLU A OE2 1 ATOM 1747 N N . PRO A 1 232 ? 25.961 -2.232 -2.215 1.00 11.37 ? 232 PRO A N 1 ATOM 1748 C CA . PRO A 1 232 ? 26.736 -2.047 -3.438 1.00 10.45 ? 232 PRO A CA 1 ATOM 1749 C C . PRO A 1 232 ? 27.385 -0.658 -3.494 1.00 10.71 ? 232 PRO A C 1 ATOM 1750 O O . PRO A 1 232 ? 26.782 0.338 -3.083 1.00 10.01 ? 232 PRO A O 1 ATOM 1751 C CB . PRO A 1 232 ? 25.670 -2.159 -4.521 1.00 10.35 ? 232 PRO A CB 1 ATOM 1752 C CG . PRO A 1 232 ? 24.420 -1.616 -3.851 1.00 11.12 ? 232 PRO A CG 1 ATOM 1753 C CD . PRO A 1 232 ? 24.505 -2.251 -2.469 1.00 10.86 ? 232 PRO A CD 1 ATOM 1754 N N . ALA A 1 233 ? 28.616 -0.604 -3.995 1.00 11.09 ? 233 ALA A N 1 ATOM 1755 C CA . ALA A 1 233 ? 29.262 0.678 -4.328 1.00 11.00 ? 233 ALA A CA 1 ATOM 1756 C C . ALA A 1 233 ? 29.481 0.777 -5.851 1.00 10.44 ? 233 ALA A C 1 ATOM 1757 O O . ALA A 1 233 ? 29.801 -0.212 -6.524 1.00 10.86 ? 233 ALA A O 1 ATOM 1758 C CB . ALA A 1 233 ? 30.585 0.834 -3.591 1.00 10.69 ? 233 ALA A CB 1 ATOM 1759 N N . VAL A 1 234 ? 29.352 1.974 -6.408 1.00 10.49 ? 234 VAL A N 1 ATOM 1760 C CA . VAL A 1 234 ? 29.476 2.104 -7.842 1.00 9.57 ? 234 VAL A CA 1 ATOM 1761 C C . VAL A 1 234 ? 30.382 3.257 -8.214 1.00 9.11 ? 234 VAL A C 1 ATOM 1762 O O . VAL A 1 234 ? 30.497 4.223 -7.483 1.00 8.46 ? 234 VAL A O 1 ATOM 1763 C CB . VAL A 1 234 ? 28.095 2.349 -8.496 1.00 9.32 ? 234 VAL A CB 1 ATOM 1764 C CG1 . VAL A 1 234 ? 27.587 3.729 -8.107 1.00 10.75 ? 234 VAL A CG1 1 ATOM 1765 C CG2 . VAL A 1 234 ? 28.206 2.268 -10.051 1.00 10.33 ? 234 VAL A CG2 1 ATOM 1766 N N . LEU A 1 235 ? 31.054 3.116 -9.352 1.00 9.29 ? 235 LEU A N 1 ATOM 1767 C CA . LEU A 1 235 ? 31.835 4.199 -9.959 1.00 9.31 ? 235 LEU A CA 1 ATOM 1768 C C . LEU A 1 235 ? 31.702 4.003 -11.456 1.00 9.54 ? 235 LEU A C 1 ATOM 1769 O O . LEU A 1 235 ? 31.146 3.011 -11.907 1.00 8.41 ? 235 LEU A O 1 ATOM 1770 C CB . LEU A 1 235 ? 33.297 4.157 -9.543 1.00 8.45 ? 235 LEU A CB 1 ATOM 1771 C CG . LEU A 1 235 ? 34.138 2.923 -9.863 1.00 9.87 ? 235 LEU A CG 1 ATOM 1772 C CD1 . LEU A 1 235 ? 34.435 2.734 -11.409 1.00 6.59 ? 235 LEU A CD1 1 ATOM 1773 C CD2 . LEU A 1 235 ? 35.453 2.913 -8.986 1.00 9.55 ? 235 LEU A CD2 1 ATOM 1774 N N . GLU A 1 236 ? 32.236 4.945 -12.226 1.00 11.49 ? 236 GLU A N 1 ATOM 1775 C CA . GLU A 1 236 ? 32.171 4.868 -13.671 1.00 11.39 ? 236 GLU A CA 1 ATOM 1776 C C . GLU A 1 236 ? 33.560 4.692 -14.231 1.00 11.48 ? 236 GLU A C 1 ATOM 1777 O O . GLU A 1 236 ? 34.489 5.416 -13.881 1.00 11.08 ? 236 GLU A O 1 ATOM 1778 C CB . GLU A 1 236 ? 31.553 6.157 -14.250 1.00 12.75 ? 236 GLU A CB 1 ATOM 1779 C CG . GLU A 1 236 ? 31.418 6.153 -15.792 1.00 15.29 ? 236 GLU A CG 1 ATOM 1780 C CD . GLU A 1 236 ? 30.546 7.304 -16.349 1.00 19.79 ? 236 GLU A CD 1 ATOM 1781 O OE1 . GLU A 1 236 ? 30.763 8.453 -15.944 1.00 19.86 ? 236 GLU A OE1 1 ATOM 1782 O OE2 . GLU A 1 236 ? 29.625 7.056 -17.188 1.00 22.75 ? 236 GLU A OE2 1 ATOM 1783 N N . TRP A 1 237 ? 33.712 3.742 -15.129 1.00 11.14 ? 237 TRP A N 1 ATOM 1784 C CA . TRP A 1 237 ? 35.030 3.496 -15.669 1.00 11.55 ? 237 TRP A CA 1 ATOM 1785 C C . TRP A 1 237 ? 34.941 3.234 -17.165 1.00 12.42 ? 237 TRP A C 1 ATOM 1786 O O . TRP A 1 237 ? 34.231 2.324 -17.601 1.00 12.38 ? 237 TRP A O 1 ATOM 1787 C CB . TRP A 1 237 ? 35.683 2.319 -14.944 1.00 9.40 ? 237 TRP A CB 1 ATOM 1788 C CG . TRP A 1 237 ? 37.058 1.974 -15.467 1.00 9.09 ? 237 TRP A CG 1 ATOM 1789 C CD1 . TRP A 1 237 ? 37.352 1.039 -16.430 1.00 8.10 ? 237 TRP A CD1 1 ATOM 1790 C CD2 . TRP A 1 237 ? 38.324 2.526 -15.057 1.00 9.01 ? 237 TRP A CD2 1 ATOM 1791 N NE1 . TRP A 1 237 ? 38.710 0.980 -16.632 1.00 8.85 ? 237 TRP A NE1 1 ATOM 1792 C CE2 . TRP A 1 237 ? 39.333 1.873 -15.803 1.00 9.22 ? 237 TRP A CE2 1 ATOM 1793 C CE3 . TRP A 1 237 ? 38.713 3.495 -14.118 1.00 6.78 ? 237 TRP A CE3 1 ATOM 1794 C CZ2 . TRP A 1 237 ? 40.701 2.175 -15.663 1.00 8.79 ? 237 TRP A CZ2 1 ATOM 1795 C CZ3 . TRP A 1 237 ? 40.051 3.772 -13.964 1.00 7.09 ? 237 TRP A CZ3 1 ATOM 1796 C CH2 . TRP A 1 237 ? 41.038 3.123 -14.725 1.00 7.03 ? 237 TRP A CH2 1 ATOM 1797 N N . GLU A 1 238 ? 35.602 4.084 -17.954 1.00 13.97 ? 238 GLU A N 1 ATOM 1798 C CA . GLU A 1 238 ? 35.601 3.903 -19.414 1.00 15.12 ? 238 GLU A CA 1 ATOM 1799 C C . GLU A 1 238 ? 34.227 3.614 -19.999 1.00 15.60 ? 238 GLU A C 1 ATOM 1800 O O . GLU A 1 238 ? 34.042 2.646 -20.755 1.00 14.81 ? 238 GLU A O 1 ATOM 1801 C CB . GLU A 1 238 ? 36.624 2.853 -19.837 1.00 15.26 ? 238 GLU A CB 1 ATOM 1802 C CG . GLU A 1 238 ? 38.009 3.295 -19.347 1.00 18.05 ? 238 GLU A CG 1 ATOM 1803 C CD . GLU A 1 238 ? 39.178 2.450 -19.814 1.00 22.75 ? 238 GLU A CD 1 ATOM 1804 O OE1 . GLU A 1 238 ? 38.987 1.297 -20.308 1.00 21.75 ? 238 GLU A OE1 1 ATOM 1805 O OE2 . GLU A 1 238 ? 40.315 2.950 -19.637 1.00 24.03 ? 238 GLU A OE2 1 ATOM 1806 N N . GLY A 1 239 ? 33.281 4.485 -19.645 1.00 15.50 ? 239 GLY A N 1 ATOM 1807 C CA . GLY A 1 239 ? 31.937 4.422 -20.192 1.00 16.30 ? 239 GLY A CA 1 ATOM 1808 C C . GLY A 1 239 ? 31.065 3.367 -19.543 1.00 17.01 ? 239 GLY A C 1 ATOM 1809 O O . GLY A 1 239 ? 29.998 3.096 -20.063 1.00 18.30 ? 239 GLY A O 1 ATOM 1810 N N . LYS A 1 240 ? 31.503 2.747 -18.441 1.00 16.06 ? 240 LYS A N 1 ATOM 1811 C CA . LYS A 1 240 ? 30.678 1.724 -17.791 1.00 15.32 ? 240 LYS A CA 1 ATOM 1812 C C . LYS A 1 240 ? 30.532 1.944 -16.298 1.00 14.43 ? 240 LYS A C 1 ATOM 1813 O O . LYS A 1 240 ? 31.425 2.491 -15.629 1.00 14.16 ? 240 LYS A O 1 ATOM 1814 C CB . LYS A 1 240 ? 31.266 0.327 -17.985 1.00 15.47 ? 240 LYS A CB 1 ATOM 1815 C CG . LYS A 1 240 ? 31.195 -0.193 -19.395 1.00 18.84 ? 240 LYS A CG 1 ATOM 1816 C CD . LYS A 1 240 ? 32.483 -0.780 -19.884 1.00 25.11 ? 240 LYS A CD 1 ATOM 1817 C CE . LYS A 1 240 ? 32.425 -2.293 -19.906 1.00 29.63 ? 240 LYS A CE 1 ATOM 1818 N NZ . LYS A 1 240 ? 32.985 -2.889 -21.192 1.00 26.63 ? 240 LYS A NZ 1 ATOM 1819 N N . LEU A 1 241 ? 29.409 1.497 -15.767 1.00 13.15 ? 241 LEU A N 1 ATOM 1820 C CA . LEU A 1 241 ? 29.228 1.491 -14.324 1.00 12.70 ? 241 LEU A CA 1 ATOM 1821 C C . LEU A 1 241 ? 29.917 0.222 -13.805 1.00 12.18 ? 241 LEU A C 1 ATOM 1822 O O . LEU A 1 241 ? 29.746 -0.825 -14.388 1.00 10.51 ? 241 LEU A O 1 ATOM 1823 C CB . LEU A 1 241 ? 27.729 1.374 -14.019 1.00 12.15 ? 241 LEU A CB 1 ATOM 1824 C CG . LEU A 1 241 ? 26.999 2.628 -14.486 1.00 10.96 ? 241 LEU A CG 1 ATOM 1825 C CD1 . LEU A 1 241 ? 25.534 2.601 -14.047 1.00 9.41 ? 241 LEU A CD1 1 ATOM 1826 C CD2 . LEU A 1 241 ? 27.717 3.793 -13.874 1.00 7.78 ? 241 LEU A CD2 1 ATOM 1827 N N . ILE A 1 242 ? 30.697 0.316 -12.736 1.00 11.65 ? 242 ILE A N 1 ATOM 1828 C CA . ILE A 1 242 ? 31.239 -0.892 -12.125 1.00 10.80 ? 242 ILE A CA 1 ATOM 1829 C C . ILE A 1 242 ? 30.621 -1.016 -10.763 1.00 10.81 ? 242 ILE A C 1 ATOM 1830 O O . ILE A 1 242 ? 30.714 -0.108 -9.953 1.00 11.79 ? 242 ILE A O 1 ATOM 1831 C CB . ILE A 1 242 ? 32.742 -0.809 -12.026 1.00 12.10 ? 242 ILE A CB 1 ATOM 1832 C CG1 . ILE A 1 242 ? 33.313 -0.450 -13.392 1.00 11.89 ? 242 ILE A CG1 1 ATOM 1833 C CG2 . ILE A 1 242 ? 33.323 -2.133 -11.550 1.00 10.30 ? 242 ILE A CG2 1 ATOM 1834 C CD1 . ILE A 1 242 ? 34.818 -0.790 -13.533 1.00 17.62 ? 242 ILE A CD1 1 ATOM 1835 N N . ILE A 1 243 ? 29.922 -2.106 -10.519 1.00 9.18 ? 243 ILE A N 1 ATOM 1836 C CA . ILE A 1 243 ? 29.213 -2.246 -9.281 1.00 9.49 ? 243 ILE A CA 1 ATOM 1837 C C . ILE A 1 243 ? 29.872 -3.314 -8.462 1.00 9.22 ? 243 ILE A C 1 ATOM 1838 O O . ILE A 1 243 ? 29.897 -4.457 -8.876 1.00 7.32 ? 243 ILE A O 1 ATOM 1839 C CB . ILE A 1 243 ? 27.702 -2.579 -9.548 1.00 9.85 ? 243 ILE A CB 1 ATOM 1840 C CG1 . ILE A 1 243 ? 27.137 -1.588 -10.557 1.00 11.64 ? 243 ILE A CG1 1 ATOM 1841 C CG2 . ILE A 1 243 ? 26.908 -2.418 -8.264 1.00 10.41 ? 243 ILE A CG2 1 ATOM 1842 C CD1 . ILE A 1 243 ? 26.449 -2.220 -11.751 1.00 15.55 ? 243 ILE A CD1 1 ATOM 1843 N N . ASN A 1 244 ? 30.413 -2.902 -7.304 1.00 9.65 ? 244 ASN A N 1 ATOM 1844 C CA . ASN A 1 244 ? 31.233 -3.748 -6.428 1.00 9.39 ? 244 ASN A CA 1 ATOM 1845 C C . ASN A 1 244 ? 30.384 -4.084 -5.194 1.00 9.65 ? 244 ASN A C 1 ATOM 1846 O O . ASN A 1 244 ? 30.054 -3.186 -4.394 1.00 9.36 ? 244 ASN A O 1 ATOM 1847 C CB . ASN A 1 244 ? 32.470 -2.959 -6.023 1.00 8.69 ? 244 ASN A CB 1 ATOM 1848 C CG . ASN A 1 244 ? 33.515 -3.813 -5.327 1.00 10.48 ? 244 ASN A CG 1 ATOM 1849 O OD1 . ASN A 1 244 ? 33.175 -4.692 -4.529 1.00 11.12 ? 244 ASN A OD1 1 ATOM 1850 N ND2 . ASN A 1 244 ? 34.809 -3.553 -5.618 1.00 7.88 ? 244 ASN A ND2 1 ATOM 1851 N N . ASN A 1 245 ? 30.018 -5.355 -5.039 1.00 9.12 ? 245 ASN A N 1 ATOM 1852 C CA . ASN A 1 245 ? 29.050 -5.712 -3.999 1.00 8.48 ? 245 ASN A CA 1 ATOM 1853 C C . ASN A 1 245 ? 29.586 -6.353 -2.746 1.00 8.83 ? 245 ASN A C 1 ATOM 1854 O O . ASN A 1 245 ? 30.522 -7.152 -2.803 1.00 7.01 ? 245 ASN A O 1 ATOM 1855 C CB . ASN A 1 245 ? 28.001 -6.696 -4.550 1.00 7.74 ? 245 ASN A CB 1 ATOM 1856 C CG . ASN A 1 245 ? 27.228 -6.126 -5.750 1.00 8.21 ? 245 ASN A CG 1 ATOM 1857 O OD1 . ASN A 1 245 ? 26.161 -5.548 -5.587 1.00 6.93 ? 245 ASN A OD1 1 ATOM 1858 N ND2 . ASN A 1 245 ? 27.766 -6.312 -6.950 1.00 7.17 ? 245 ASN A ND2 1 ATOM 1859 N N . ARG A 1 246 ? 28.950 -6.031 -1.617 1.00 8.25 ? 246 ARG A N 1 ATOM 1860 C CA . ARG A 1 246 ? 29.155 -6.804 -0.406 1.00 8.22 ? 246 ARG A CA 1 ATOM 1861 C C . ARG A 1 246 ? 28.457 -8.166 -0.622 1.00 9.09 ? 246 ARG A C 1 ATOM 1862 O O . ARG A 1 246 ? 27.344 -8.242 -1.221 1.00 8.45 ? 246 ARG A O 1 ATOM 1863 C CB . ARG A 1 246 ? 28.499 -6.091 0.786 1.00 8.52 ? 246 ARG A CB 1 ATOM 1864 C CG . ARG A 1 246 ? 28.568 -6.878 2.090 1.00 9.75 ? 246 ARG A CG 1 ATOM 1865 C CD . ARG A 1 246 ? 28.280 -6.088 3.372 1.00 9.21 ? 246 ARG A CD 1 ATOM 1866 N NE . ARG A 1 246 ? 27.850 -6.996 4.414 1.00 9.96 ? 246 ARG A NE 1 ATOM 1867 C CZ . ARG A 1 246 ? 27.455 -6.619 5.625 1.00 11.48 ? 246 ARG A CZ 1 ATOM 1868 N NH1 . ARG A 1 246 ? 27.468 -5.351 5.953 1.00 14.27 ? 246 ARG A NH1 1 ATOM 1869 N NH2 . ARG A 1 246 ? 27.055 -7.515 6.503 1.00 10.11 ? 246 ARG A NH2 1 ATOM 1870 N N . VAL A 1 247 ? 29.100 -9.240 -0.178 1.00 9.09 ? 247 VAL A N 1 ATOM 1871 C CA . VAL A 1 247 ? 28.514 -10.581 -0.270 1.00 8.67 ? 247 VAL A CA 1 ATOM 1872 C C . VAL A 1 247 ? 28.878 -11.324 0.999 1.00 9.63 ? 247 VAL A C 1 ATOM 1873 O O . VAL A 1 247 ? 30.026 -11.760 1.144 1.00 8.78 ? 247 VAL A O 1 ATOM 1874 C CB . VAL A 1 247 ? 29.084 -11.375 -1.468 1.00 9.52 ? 247 VAL A CB 1 ATOM 1875 C CG1 . VAL A 1 247 ? 28.503 -12.844 -1.519 1.00 6.94 ? 247 VAL A CG1 1 ATOM 1876 C CG2 . VAL A 1 247 ? 28.804 -10.622 -2.830 1.00 6.08 ? 247 VAL A CG2 1 ATOM 1877 N N . ASP A 1 248 ? 27.940 -11.449 1.936 1.00 10.05 ? 248 ASP A N 1 ATOM 1878 C CA . ASP A 1 248 ? 28.256 -12.169 3.166 1.00 11.01 ? 248 ASP A CA 1 ATOM 1879 C C . ASP A 1 248 ? 28.392 -13.647 2.843 1.00 11.37 ? 248 ASP A C 1 ATOM 1880 O O . ASP A 1 248 ? 27.554 -14.201 2.121 1.00 10.78 ? 248 ASP A O 1 ATOM 1881 C CB . ASP A 1 248 ? 27.158 -12.042 4.200 1.00 12.17 ? 248 ASP A CB 1 ATOM 1882 C CG . ASP A 1 248 ? 26.918 -10.607 4.652 1.00 14.03 ? 248 ASP A CG 1 ATOM 1883 O OD1 . ASP A 1 248 ? 25.718 -10.292 4.860 1.00 18.75 ? 248 ASP A OD1 1 ATOM 1884 O OD2 . ASP A 1 248 ? 27.826 -9.754 4.846 1.00 13.00 ? 248 ASP A OD2 1 ATOM 1885 N N . GLY A 1 249 ? 29.419 -14.296 3.393 1.00 11.77 ? 249 GLY A N 1 ATOM 1886 C CA . GLY A 1 249 ? 29.569 -15.753 3.233 1.00 11.52 ? 249 GLY A CA 1 ATOM 1887 C C . GLY A 1 249 ? 30.148 -16.233 1.924 1.00 12.10 ? 249 GLY A C 1 ATOM 1888 O O . GLY A 1 249 ? 30.135 -17.432 1.645 1.00 11.99 ? 249 GLY A O 1 ATOM 1889 N N . ASN A 1 250 ? 30.636 -15.302 1.114 1.00 12.28 ? 250 ASN A N 1 ATOM 1890 C CA . ASN A 1 250 ? 31.291 -15.655 -0.138 1.00 13.19 ? 250 ASN A CA 1 ATOM 1891 C C . ASN A 1 250 ? 32.072 -14.493 -0.721 1.00 12.62 ? 250 ASN A C 1 ATOM 1892 O O . ASN A 1 250 ? 32.000 -13.390 -0.198 1.00 12.27 ? 250 ASN A O 1 ATOM 1893 C CB . ASN A 1 250 ? 30.284 -16.174 -1.156 1.00 13.39 ? 250 ASN A CB 1 ATOM 1894 C CG . ASN A 1 250 ? 30.841 -17.336 -1.977 1.00 18.56 ? 250 ASN A CG 1 ATOM 1895 O OD1 . ASN A 1 250 ? 30.112 -18.293 -2.257 1.00 24.01 ? 250 ASN A OD1 1 ATOM 1896 N ND2 . ASN A 1 250 ? 32.143 -17.259 -2.389 1.00 19.18 ? 250 ASN A ND2 1 ATOM 1897 N N . ARG A 1 251 ? 32.793 -14.742 -1.814 1.00 13.08 ? 251 ARG A N 1 ATOM 1898 C CA . ARG A 1 251 ? 33.623 -13.722 -2.455 1.00 12.57 ? 251 ARG A CA 1 ATOM 1899 C C . ARG A 1 251 ? 32.796 -12.620 -3.081 1.00 13.03 ? 251 ARG A C 1 ATOM 1900 O O . ARG A 1 251 ? 31.628 -12.814 -3.468 1.00 13.14 ? 251 ARG A O 1 ATOM 1901 C CB . ARG A 1 251 ? 34.616 -14.353 -3.446 1.00 12.19 ? 251 ARG A CB 1 ATOM 1902 C CG . ARG A 1 251 ? 35.574 -15.337 -2.731 1.00 11.69 ? 251 ARG A CG 1 ATOM 1903 C CD . ARG A 1 251 ? 36.693 -15.884 -3.551 1.00 14.84 ? 251 ARG A CD 1 ATOM 1904 N NE . ARG A 1 251 ? 37.658 -14.811 -3.701 1.00 16.55 ? 251 ARG A NE 1 ATOM 1905 C CZ . ARG A 1 251 ? 38.740 -14.628 -2.955 1.00 13.74 ? 251 ARG A CZ 1 ATOM 1906 N NH1 . ARG A 1 251 ? 39.449 -13.559 -3.208 1.00 14.10 ? 251 ARG A NH1 1 ATOM 1907 N NH2 . ARG A 1 251 ? 39.127 -15.495 -2.007 1.00 9.98 ? 251 ARG A NH2 1 ATOM 1908 N N . ARG A 1 252 ? 33.405 -11.440 -3.145 1.00 12.47 ? 252 ARG A N 1 ATOM 1909 C CA . ARG A 1 252 ? 32.713 -10.250 -3.632 1.00 12.06 ? 252 ARG A CA 1 ATOM 1910 C C . ARG A 1 252 ? 32.505 -10.255 -5.136 1.00 11.41 ? 252 ARG A C 1 ATOM 1911 O O . ARG A 1 252 ? 33.437 -10.367 -5.914 1.00 10.80 ? 252 ARG A O 1 ATOM 1912 C CB . ARG A 1 252 ? 33.470 -8.975 -3.229 1.00 11.58 ? 252 ARG A CB 1 ATOM 1913 C CG . ARG A 1 252 ? 33.502 -8.746 -1.740 1.00 11.17 ? 252 ARG A CG 1 ATOM 1914 C CD . ARG A 1 252 ? 34.295 -7.533 -1.310 1.00 10.81 ? 252 ARG A CD 1 ATOM 1915 N NE . ARG A 1 252 ? 33.701 -6.302 -1.857 1.00 11.89 ? 252 ARG A NE 1 ATOM 1916 C CZ . ARG A 1 252 ? 32.845 -5.553 -1.185 1.00 12.94 ? 252 ARG A CZ 1 ATOM 1917 N NH1 . ARG A 1 252 ? 32.344 -4.457 -1.727 1.00 13.43 ? 252 ARG A NH1 1 ATOM 1918 N NH2 . ARG A 1 252 ? 32.463 -5.919 0.023 1.00 11.07 ? 252 ARG A NH2 1 ATOM 1919 N N . LEU A 1 253 ? 31.259 -10.092 -5.516 1.00 11.24 ? 253 LEU A N 1 ATOM 1920 C CA . LEU A 1 253 ? 30.874 -10.079 -6.913 1.00 10.90 ? 253 LEU A CA 1 ATOM 1921 C C . LEU A 1 253 ? 30.937 -8.667 -7.461 1.00 9.88 ? 253 LEU A C 1 ATOM 1922 O O . LEU A 1 253 ? 30.465 -7.703 -6.819 1.00 9.48 ? 253 LEU A O 1 ATOM 1923 C CB . LEU A 1 253 ? 29.462 -10.644 -7.083 1.00 9.72 ? 253 LEU A CB 1 ATOM 1924 C CG . LEU A 1 253 ? 29.277 -12.103 -6.712 1.00 13.05 ? 253 LEU A CG 1 ATOM 1925 C CD1 . LEU A 1 253 ? 27.785 -12.494 -6.677 1.00 14.59 ? 253 LEU A CD1 1 ATOM 1926 C CD2 . LEU A 1 253 ? 30.005 -12.991 -7.720 1.00 15.19 ? 253 LEU A CD2 1 ATOM 1927 N N . VAL A 1 254 ? 31.481 -8.548 -8.662 1.00 8.69 ? 254 VAL A N 1 ATOM 1928 C CA . VAL A 1 254 ? 31.583 -7.236 -9.296 1.00 7.95 ? 254 VAL A CA 1 ATOM 1929 C C . VAL A 1 254 ? 30.942 -7.301 -10.656 1.00 8.59 ? 254 VAL A C 1 ATOM 1930 O O . VAL A 1 254 ? 31.141 -8.270 -11.361 1.00 10.04 ? 254 VAL A O 1 ATOM 1931 C CB . VAL A 1 254 ? 33.039 -6.798 -9.408 1.00 7.32 ? 254 VAL A CB 1 ATOM 1932 C CG1 . VAL A 1 254 ? 33.144 -5.435 -10.112 1.00 5.28 ? 254 VAL A CG1 1 ATOM 1933 C CG2 . VAL A 1 254 ? 33.641 -6.707 -8.005 1.00 6.80 ? 254 VAL A CG2 1 ATOM 1934 N N . TYR A 1 255 ? 30.157 -6.299 -11.032 1.00 9.16 ? 255 TYR A N 1 ATOM 1935 C CA . TYR A 1 255 ? 29.490 -6.317 -12.336 1.00 10.58 ? 255 TYR A CA 1 ATOM 1936 C C . TYR A 1 255 ? 29.790 -5.052 -13.100 1.00 11.76 ? 255 TYR A C 1 ATOM 1937 O O . TYR A 1 255 ? 30.141 -4.008 -12.490 1.00 11.57 ? 255 TYR A O 1 ATOM 1938 C CB . TYR A 1 255 ? 27.961 -6.376 -12.179 1.00 10.33 ? 255 TYR A CB 1 ATOM 1939 C CG . TYR A 1 255 ? 27.450 -7.617 -11.492 1.00 10.48 ? 255 TYR A CG 1 ATOM 1940 C CD1 . TYR A 1 255 ? 27.380 -7.696 -10.091 1.00 9.05 ? 255 TYR A CD1 1 ATOM 1941 C CD2 . TYR A 1 255 ? 27.050 -8.721 -12.229 1.00 8.70 ? 255 TYR A CD2 1 ATOM 1942 C CE1 . TYR A 1 255 ? 26.903 -8.848 -9.467 1.00 8.65 ? 255 TYR A CE1 1 ATOM 1943 C CE2 . TYR A 1 255 ? 26.585 -9.877 -11.602 1.00 10.28 ? 255 TYR A CE2 1 ATOM 1944 C CZ . TYR A 1 255 ? 26.500 -9.921 -10.231 1.00 9.85 ? 255 TYR A CZ 1 ATOM 1945 O OH . TYR A 1 255 ? 26.042 -11.060 -9.628 1.00 14.96 ? 255 TYR A OH 1 ATOM 1946 N N . GLU A 1 256 ? 29.636 -5.128 -14.420 1.00 12.13 ? 256 GLU A N 1 ATOM 1947 C CA . GLU A 1 256 ? 29.789 -3.938 -15.269 1.00 14.38 ? 256 GLU A CA 1 ATOM 1948 C C . GLU A 1 256 ? 28.502 -3.753 -16.083 1.00 14.15 ? 256 GLU A C 1 ATOM 1949 O O . GLU A 1 256 ? 27.912 -4.746 -16.537 1.00 13.47 ? 256 GLU A O 1 ATOM 1950 C CB . GLU A 1 256 ? 30.978 -4.072 -16.250 1.00 13.70 ? 256 GLU A CB 1 ATOM 1951 C CG . GLU A 1 256 ? 32.349 -4.018 -15.592 1.00 18.43 ? 256 GLU A CG 1 ATOM 1952 C CD . GLU A 1 256 ? 33.513 -4.289 -16.565 1.00 21.79 ? 256 GLU A CD 1 ATOM 1953 O OE1 . GLU A 1 256 ? 34.680 -3.858 -16.269 1.00 23.11 ? 256 GLU A OE1 1 ATOM 1954 O OE2 . GLU A 1 256 ? 33.243 -4.903 -17.626 1.00 23.23 ? 256 GLU A OE2 1 ATOM 1955 N N . SER A 1 257 ? 28.109 -2.493 -16.294 1.00 13.75 ? 257 SER A N 1 ATOM 1956 C CA . SER A 1 257 ? 26.950 -2.163 -17.119 1.00 14.18 ? 257 SER A CA 1 ATOM 1957 C C . SER A 1 257 ? 27.292 -1.002 -18.018 1.00 15.11 ? 257 SER A C 1 ATOM 1958 O O . SER A 1 257 ? 27.705 0.056 -17.537 1.00 15.06 ? 257 SER A O 1 ATOM 1959 C CB . SER A 1 257 ? 25.750 -1.794 -16.256 1.00 13.62 ? 257 SER A CB 1 ATOM 1960 O OG . SER A 1 257 ? 24.669 -1.342 -17.049 1.00 14.09 ? 257 SER A OG 1 ATOM 1961 N N . SER A 1 258 ? 27.126 -1.211 -19.325 1.00 15.64 ? 258 SER A N 1 ATOM 1962 C CA . SER A 1 258 ? 27.375 -0.190 -20.361 1.00 16.55 ? 258 SER A CA 1 ATOM 1963 C C . SER A 1 258 ? 26.117 0.625 -20.691 1.00 16.65 ? 258 SER A C 1 ATOM 1964 O O . SER A 1 258 ? 26.155 1.527 -21.523 1.00 16.39 ? 258 SER A O 1 ATOM 1965 C CB . SER A 1 258 ? 27.778 -0.889 -21.667 1.00 16.25 ? 258 SER A CB 1 ATOM 1966 O OG . SER A 1 258 ? 28.913 -1.736 -21.464 1.00 22.34 ? 258 SER A OG 1 ATOM 1967 N N . ASP A 1 259 ? 24.986 0.289 -20.090 1.00 16.97 ? 259 ASP A N 1 ATOM 1968 C CA . ASP A 1 259 ? 23.747 0.989 -20.462 1.00 17.30 ? 259 ASP A CA 1 ATOM 1969 C C . ASP A 1 259 ? 22.994 1.502 -19.234 1.00 16.75 ? 259 ASP A C 1 ATOM 1970 O O . ASP A 1 259 ? 21.806 1.267 -19.071 1.00 17.48 ? 259 ASP A O 1 ATOM 1971 C CB . ASP A 1 259 ? 22.896 0.059 -21.349 1.00 17.50 ? 259 ASP A CB 1 ATOM 1972 C CG . ASP A 1 259 ? 22.782 -1.343 -20.747 1.00 18.85 ? 259 ASP A CG 1 ATOM 1973 O OD1 . ASP A 1 259 ? 22.291 -2.288 -21.427 1.00 17.81 ? 259 ASP A OD1 1 ATOM 1974 O OD2 . ASP A 1 259 ? 23.164 -1.550 -19.561 1.00 18.15 ? 259 ASP A OD2 1 ATOM 1975 N N . MET A 1 260 ? 23.703 2.205 -18.350 1.00 16.67 ? 260 MET A N 1 ATOM 1976 C CA . MET A 1 260 ? 23.072 2.799 -17.187 1.00 16.32 ? 260 MET A CA 1 ATOM 1977 C C . MET A 1 260 ? 22.283 1.735 -16.384 1.00 15.37 ? 260 MET A C 1 ATOM 1978 O O . MET A 1 260 ? 21.155 1.960 -15.935 1.00 14.88 ? 260 MET A O 1 ATOM 1979 C CB . MET A 1 260 ? 22.171 3.954 -17.649 1.00 16.68 ? 260 MET A CB 1 ATOM 1980 C CG . MET A 1 260 ? 21.741 4.951 -16.556 1.00 20.28 ? 260 MET A CG 1 ATOM 1981 S SD . MET A 1 260 ? 23.159 5.721 -15.717 1.00 25.47 ? 260 MET A SD 1 ATOM 1982 C CE . MET A 1 260 ? 23.286 4.709 -14.410 1.00 26.78 ? 260 MET A CE 1 ATOM 1983 N N . GLY A 1 261 ? 22.860 0.553 -16.239 1.00 14.84 ? 261 GLY A N 1 ATOM 1984 C CA . GLY A 1 261 ? 22.252 -0.492 -15.427 1.00 14.07 ? 261 GLY A CA 1 ATOM 1985 C C . GLY A 1 261 ? 21.207 -1.407 -16.040 1.00 14.73 ? 261 GLY A C 1 ATOM 1986 O O . GLY A 1 261 ? 20.767 -2.356 -15.394 1.00 13.31 ? 261 GLY A O 1 ATOM 1987 N N . LYS A 1 262 ? 20.817 -1.145 -17.288 1.00 15.73 ? 262 LYS A N 1 ATOM 1988 C CA . LYS A 1 262 ? 19.797 -1.977 -17.922 1.00 17.23 ? 262 LYS A CA 1 ATOM 1989 C C . LYS A 1 262 ? 20.287 -3.397 -18.035 1.00 17.35 ? 262 LYS A C 1 ATOM 1990 O O . LYS A 1 262 ? 19.541 -4.350 -17.794 1.00 16.35 ? 262 LYS A O 1 ATOM 1991 C CB . LYS A 1 262 ? 19.394 -1.429 -19.293 1.00 18.43 ? 262 LYS A CB 1 ATOM 1992 C CG . LYS A 1 262 ? 18.380 -2.305 -20.047 1.00 21.15 ? 262 LYS A CG 1 ATOM 1993 C CD . LYS A 1 262 ? 17.921 -1.585 -21.315 1.00 29.32 ? 262 LYS A CD 1 ATOM 1994 C CE . LYS A 1 262 ? 17.408 -2.550 -22.407 1.00 35.82 ? 262 LYS A CE 1 ATOM 1995 N NZ . LYS A 1 262 ? 18.495 -2.898 -23.410 1.00 40.75 ? 262 LYS A NZ 1 ATOM 1996 N N . THR A 1 263 ? 21.565 -3.550 -18.340 1.00 17.74 ? 263 THR A N 1 ATOM 1997 C CA . THR A 1 263 ? 22.095 -4.889 -18.389 1.00 19.00 ? 263 THR A CA 1 ATOM 1998 C C . THR A 1 263 ? 23.454 -5.013 -17.645 1.00 18.56 ? 263 THR A C 1 ATOM 1999 O O . THR A 1 263 ? 24.341 -4.154 -17.807 1.00 18.27 ? 263 THR A O 1 ATOM 2000 C CB . THR A 1 263 ? 22.058 -5.420 -19.875 1.00 19.78 ? 263 THR A CB 1 ATOM 2001 O OG1 . THR A 1 263 ? 23.056 -6.424 -20.081 1.00 26.00 ? 263 THR A OG1 1 ATOM 2002 C CG2 . THR A 1 263 ? 22.450 -4.384 -20.851 1.00 20.36 ? 263 THR A CG2 1 ATOM 2003 N N . TRP A 1 264 ? 23.560 -6.029 -16.780 1.00 16.94 ? 264 TRP A N 1 ATOM 2004 C CA . TRP A 1 264 ? 24.740 -6.272 -15.927 1.00 16.48 ? 264 TRP A CA 1 ATOM 2005 C C . TRP A 1 264 ? 25.481 -7.511 -16.431 1.00 15.86 ? 264 TRP A C 1 ATOM 2006 O O . TRP A 1 264 ? 24.870 -8.446 -16.894 1.00 15.08 ? 264 TRP A O 1 ATOM 2007 C CB . TRP A 1 264 ? 24.338 -6.534 -14.448 1.00 15.91 ? 264 TRP A CB 1 ATOM 2008 C CG . TRP A 1 264 ? 23.746 -5.360 -13.724 1.00 15.00 ? 264 TRP A CG 1 ATOM 2009 C CD1 . TRP A 1 264 ? 23.022 -4.355 -14.276 1.00 14.43 ? 264 TRP A CD1 1 ATOM 2010 C CD2 . TRP A 1 264 ? 23.814 -5.078 -12.319 1.00 11.22 ? 264 TRP A CD2 1 ATOM 2011 N NE1 . TRP A 1 264 ? 22.641 -3.455 -13.314 1.00 13.81 ? 264 TRP A NE1 1 ATOM 2012 C CE2 . TRP A 1 264 ? 23.098 -3.888 -12.097 1.00 13.66 ? 264 TRP A CE2 1 ATOM 2013 C CE3 . TRP A 1 264 ? 24.401 -5.716 -11.221 1.00 7.75 ? 264 TRP A CE3 1 ATOM 2014 C CZ2 . TRP A 1 264 ? 22.980 -3.299 -10.829 1.00 9.95 ? 264 TRP A CZ2 1 ATOM 2015 C CZ3 . TRP A 1 264 ? 24.314 -5.129 -9.984 1.00 8.73 ? 264 TRP A CZ3 1 ATOM 2016 C CH2 . TRP A 1 264 ? 23.614 -3.928 -9.792 1.00 11.23 ? 264 TRP A CH2 1 ATOM 2017 N N . VAL A 1 265 ? 26.796 -7.503 -16.329 1.00 15.81 ? 265 VAL A N 1 ATOM 2018 C CA . VAL A 1 265 ? 27.648 -8.616 -16.779 1.00 16.96 ? 265 VAL A CA 1 ATOM 2019 C C . VAL A 1 265 ? 28.703 -8.783 -15.698 1.00 15.78 ? 265 VAL A C 1 ATOM 2020 O O . VAL A 1 265 ? 29.333 -7.810 -15.280 1.00 15.28 ? 265 VAL A O 1 ATOM 2021 C CB . VAL A 1 265 ? 28.405 -8.243 -18.099 1.00 17.46 ? 265 VAL A CB 1 ATOM 2022 C CG1 . VAL A 1 265 ? 29.550 -9.223 -18.391 1.00 20.87 ? 265 VAL A CG1 1 ATOM 2023 C CG2 . VAL A 1 265 ? 27.434 -8.163 -19.296 1.00 19.77 ? 265 VAL A CG2 1 ATOM 2024 N N . GLU A 1 266 ? 28.911 -9.997 -15.236 1.00 14.55 ? 266 GLU A N 1 ATOM 2025 C CA . GLU A 1 266 ? 29.888 -10.172 -14.185 1.00 12.98 ? 266 GLU A CA 1 ATOM 2026 C C . GLU A 1 266 ? 31.258 -9.839 -14.692 1.00 12.39 ? 266 GLU A C 1 ATOM 2027 O O . GLU A 1 266 ? 31.647 -10.289 -15.779 1.00 11.31 ? 266 GLU A O 1 ATOM 2028 C CB . GLU A 1 266 ? 29.906 -11.600 -13.639 1.00 13.08 ? 266 GLU A CB 1 ATOM 2029 C CG . GLU A 1 266 ? 30.659 -11.622 -12.292 1.00 11.67 ? 266 GLU A CG 1 ATOM 2030 C CD . GLU A 1 266 ? 30.576 -12.953 -11.562 1.00 12.20 ? 266 GLU A CD 1 ATOM 2031 O OE1 . GLU A 1 266 ? 29.650 -13.752 -11.828 1.00 14.74 ? 266 GLU A OE1 1 ATOM 2032 O OE2 . GLU A 1 266 ? 31.455 -13.223 -10.745 1.00 11.12 ? 266 GLU A OE2 1 ATOM 2033 N N . ALA A 1 267 ? 32.016 -9.076 -13.896 1.00 10.93 ? 267 ALA A N 1 ATOM 2034 C CA . ALA A 1 267 ? 33.371 -8.689 -14.307 1.00 10.30 ? 267 ALA A CA 1 ATOM 2035 C C . ALA A 1 267 ? 34.388 -9.825 -14.090 1.00 10.11 ? 267 ALA A C 1 ATOM 2036 O O . ALA A 1 267 ? 35.332 -9.705 -13.297 1.00 10.71 ? 267 ALA A O 1 ATOM 2037 C CB . ALA A 1 267 ? 33.781 -7.415 -13.529 1.00 10.25 ? 267 ALA A CB 1 ATOM 2038 N N . LEU A 1 268 ? 34.209 -10.933 -14.802 1.00 10.82 ? 268 LEU A N 1 ATOM 2039 C CA . LEU A 1 268 ? 35.032 -12.136 -14.627 1.00 10.53 ? 268 LEU A CA 1 ATOM 2040 C C . LEU A 1 268 ? 36.455 -11.962 -15.099 1.00 10.10 ? 268 LEU A C 1 ATOM 2041 O O . LEU A 1 268 ? 37.374 -12.670 -14.661 1.00 8.98 ? 268 LEU A O 1 ATOM 2042 C CB . LEU A 1 268 ? 34.425 -13.349 -15.380 1.00 10.94 ? 268 LEU A CB 1 ATOM 2043 C CG . LEU A 1 268 ? 33.047 -13.818 -14.877 1.00 14.89 ? 268 LEU A CG 1 ATOM 2044 C CD1 . LEU A 1 268 ? 32.488 -15.021 -15.713 1.00 14.36 ? 268 LEU A CD1 1 ATOM 2045 C CD2 . LEU A 1 268 ? 33.089 -14.171 -13.393 1.00 13.45 ? 268 LEU A CD2 1 ATOM 2046 N N . GLY A 1 269 ? 36.633 -11.065 -16.047 1.00 9.91 ? 269 GLY A N 1 ATOM 2047 C CA . GLY A 1 269 ? 37.958 -10.867 -16.600 1.00 9.78 ? 269 GLY A CA 1 ATOM 2048 C C . GLY A 1 269 ? 38.736 -9.763 -15.900 1.00 9.90 ? 269 GLY A C 1 ATOM 2049 O O . GLY A 1 269 ? 39.824 -9.431 -16.346 1.00 9.44 ? 269 GLY A O 1 ATOM 2050 N N . THR A 1 270 ? 38.193 -9.191 -14.823 1.00 9.85 ? 270 THR A N 1 ATOM 2051 C CA . THR A 1 270 ? 38.893 -8.103 -14.141 1.00 9.78 ? 270 THR A CA 1 ATOM 2052 C C . THR A 1 270 ? 38.842 -8.150 -12.607 1.00 11.02 ? 270 THR A C 1 ATOM 2053 O O . THR A 1 270 ? 39.841 -8.474 -11.939 1.00 11.28 ? 270 THR A O 1 ATOM 2054 C CB . THR A 1 270 ? 38.357 -6.690 -14.567 1.00 9.91 ? 270 THR A CB 1 ATOM 2055 O OG1 . THR A 1 270 ? 36.915 -6.628 -14.444 1.00 8.63 ? 270 THR A OG1 1 ATOM 2056 C CG2 . THR A 1 270 ? 38.709 -6.345 -16.049 1.00 9.69 ? 270 THR A CG2 1 ATOM 2057 N N . LEU A 1 271 ? 37.685 -7.814 -12.054 1.00 9.06 ? 271 LEU A N 1 ATOM 2058 C CA . LEU A 1 271 ? 37.607 -7.623 -10.636 1.00 9.44 ? 271 LEU A CA 1 ATOM 2059 C C . LEU A 1 271 ? 36.707 -8.553 -9.835 1.00 9.92 ? 271 LEU A C 1 ATOM 2060 O O . LEU A 1 271 ? 36.783 -8.587 -8.593 1.00 11.23 ? 271 LEU A O 1 ATOM 2061 C CB . LEU A 1 271 ? 37.120 -6.206 -10.398 1.00 8.61 ? 271 LEU A CB 1 ATOM 2062 C CG . LEU A 1 271 ? 37.999 -5.036 -10.852 1.00 9.00 ? 271 LEU A CG 1 ATOM 2063 C CD1 . LEU A 1 271 ? 37.315 -3.692 -10.494 1.00 8.51 ? 271 LEU A CD1 1 ATOM 2064 C CD2 . LEU A 1 271 ? 39.454 -5.065 -10.327 1.00 8.31 ? 271 LEU A CD2 1 ATOM 2065 N N . SER A 1 272 ? 35.829 -9.286 -10.493 1.00 9.48 ? 272 SER A N 1 ATOM 2066 C CA . SER A 1 272 ? 34.893 -10.099 -9.726 1.00 9.72 ? 272 SER A CA 1 ATOM 2067 C C . SER A 1 272 ? 35.620 -11.157 -8.943 1.00 9.10 ? 272 SER A C 1 ATOM 2068 O O . SER A 1 272 ? 36.538 -11.755 -9.454 1.00 8.88 ? 272 SER A O 1 ATOM 2069 C CB . SER A 1 272 ? 33.838 -10.726 -10.638 1.00 8.56 ? 272 SER A CB 1 ATOM 2070 O OG . SER A 1 272 ? 32.736 -11.022 -9.823 1.00 8.23 ? 272 SER A OG 1 ATOM 2071 N N . HIS A 1 273 ? 35.238 -11.370 -7.693 1.00 9.77 ? 273 HIS A N 1 ATOM 2072 C CA . HIS A 1 273 ? 35.873 -12.401 -6.869 1.00 10.28 ? 273 HIS A CA 1 ATOM 2073 C C . HIS A 1 273 ? 37.333 -12.161 -6.419 1.00 10.15 ? 273 HIS A C 1 ATOM 2074 O O . HIS A 1 273 ? 37.930 -13.001 -5.755 1.00 10.26 ? 273 HIS A O 1 ATOM 2075 C CB . HIS A 1 273 ? 35.708 -13.782 -7.521 1.00 11.54 ? 273 HIS A CB 1 ATOM 2076 C CG . HIS A 1 273 ? 34.407 -14.451 -7.168 1.00 15.93 ? 273 HIS A CG 1 ATOM 2077 N ND1 . HIS A 1 273 ? 34.223 -15.816 -7.221 1.00 20.66 ? 273 HIS A ND1 1 ATOM 2078 C CD2 . HIS A 1 273 ? 33.241 -13.934 -6.700 1.00 20.79 ? 273 HIS A CD2 1 ATOM 2079 C CE1 . HIS A 1 273 ? 32.995 -16.109 -6.826 1.00 23.85 ? 273 HIS A CE1 1 ATOM 2080 N NE2 . HIS A 1 273 ? 32.381 -14.986 -6.494 1.00 22.97 ? 273 HIS A NE2 1 ATOM 2081 N N . VAL A 1 274 ? 37.902 -11.014 -6.766 1.00 9.79 ? 274 VAL A N 1 ATOM 2082 C CA . VAL A 1 274 ? 39.218 -10.682 -6.284 1.00 8.68 ? 274 VAL A CA 1 ATOM 2083 C C . VAL A 1 274 ? 39.189 -10.487 -4.773 1.00 8.86 ? 274 VAL A C 1 ATOM 2084 O O . VAL A 1 274 ? 40.003 -11.021 -4.073 1.00 9.42 ? 274 VAL A O 1 ATOM 2085 C CB . VAL A 1 274 ? 39.743 -9.369 -6.940 1.00 8.90 ? 274 VAL A CB 1 ATOM 2086 C CG1 . VAL A 1 274 ? 40.968 -8.793 -6.162 1.00 7.31 ? 274 VAL A CG1 1 ATOM 2087 C CG2 . VAL A 1 274 ? 40.110 -9.629 -8.394 1.00 8.10 ? 274 VAL A CG2 1 ATOM 2088 N N . TRP A 1 275 ? 38.221 -9.741 -4.264 1.00 8.72 ? 275 TRP A N 1 ATOM 2089 C CA . TRP A 1 275 ? 38.222 -9.401 -2.848 1.00 8.38 ? 275 TRP A CA 1 ATOM 2090 C C . TRP A 1 275 ? 37.204 -10.267 -2.081 1.00 8.84 ? 275 TRP A C 1 ATOM 2091 O O . TRP A 1 275 ? 36.302 -10.849 -2.671 1.00 9.52 ? 275 TRP A O 1 ATOM 2092 C CB . TRP A 1 275 ? 37.915 -7.902 -2.676 1.00 7.82 ? 275 TRP A CB 1 ATOM 2093 C CG . TRP A 1 275 ? 39.012 -6.965 -3.152 1.00 7.86 ? 275 TRP A CG 1 ATOM 2094 C CD1 . TRP A 1 275 ? 40.214 -6.745 -2.539 1.00 7.90 ? 275 TRP A CD1 1 ATOM 2095 C CD2 . TRP A 1 275 ? 39.020 -6.143 -4.336 1.00 8.50 ? 275 TRP A CD2 1 ATOM 2096 N NE1 . TRP A 1 275 ? 40.956 -5.840 -3.249 1.00 6.93 ? 275 TRP A NE1 1 ATOM 2097 C CE2 . TRP A 1 275 ? 40.247 -5.450 -4.357 1.00 8.61 ? 275 TRP A CE2 1 ATOM 2098 C CE3 . TRP A 1 275 ? 38.107 -5.902 -5.362 1.00 7.71 ? 275 TRP A CE3 1 ATOM 2099 C CZ2 . TRP A 1 275 ? 40.586 -4.536 -5.370 1.00 7.22 ? 275 TRP A CZ2 1 ATOM 2100 C CZ3 . TRP A 1 275 ? 38.449 -5.009 -6.376 1.00 10.23 ? 275 TRP A CZ3 1 ATOM 2101 C CH2 . TRP A 1 275 ? 39.685 -4.337 -6.369 1.00 9.38 ? 275 TRP A CH2 1 ATOM 2102 N N . THR A 1 276 ? 37.336 -10.334 -0.774 1.00 9.22 ? 276 THR A N 1 ATOM 2103 C CA . THR A 1 276 ? 36.420 -11.147 -0.002 1.00 10.50 ? 276 THR A CA 1 ATOM 2104 C C . THR A 1 276 ? 36.284 -10.647 1.449 1.00 10.89 ? 276 THR A C 1 ATOM 2105 O O . THR A 1 276 ? 36.753 -9.560 1.782 1.00 11.31 ? 276 THR A O 1 ATOM 2106 C CB . THR A 1 276 ? 36.873 -12.602 -0.112 1.00 11.06 ? 276 THR A CB 1 ATOM 2107 O OG1 . THR A 1 276 ? 35.930 -13.467 0.526 1.00 9.83 ? 276 THR A OG1 1 ATOM 2108 C CG2 . THR A 1 276 ? 38.274 -12.813 0.580 1.00 8.84 ? 276 THR A CG2 1 ATOM 2109 N N . ASN A 1 277 ? 35.627 -11.435 2.295 1.00 11.18 ? 277 ASN A N 1 ATOM 2110 C CA . ASN A 1 277 ? 35.262 -11.014 3.660 1.00 10.95 ? 277 ASN A CA 1 ATOM 2111 C C . ASN A 1 277 ? 36.227 -11.410 4.774 1.00 10.41 ? 277 ASN A C 1 ATOM 2112 O O . ASN A 1 277 ? 36.090 -10.951 5.891 1.00 11.28 ? 277 ASN A O 1 ATOM 2113 C CB . ASN A 1 277 ? 33.861 -11.579 4.028 1.00 10.57 ? 277 ASN A CB 1 ATOM 2114 C CG . ASN A 1 277 ? 33.715 -13.098 3.732 1.00 12.23 ? 277 ASN A CG 1 ATOM 2115 O OD1 . ASN A 1 277 ? 33.108 -13.503 2.706 1.00 16.84 ? 277 ASN A OD1 1 ATOM 2116 N ND2 . ASN A 1 277 ? 34.271 -13.930 4.597 1.00 5.74 ? 277 ASN A ND2 1 ATOM 2117 N N . SER A 1 278 ? 37.158 -12.287 4.475 1.00 9.35 ? 278 SER A N 1 ATOM 2118 C CA . SER A 1 278 ? 38.015 -12.888 5.497 1.00 10.26 ? 278 SER A CA 1 ATOM 2119 C C . SER A 1 278 ? 38.865 -13.921 4.796 1.00 10.84 ? 278 SER A C 1 ATOM 2120 O O . SER A 1 278 ? 38.535 -14.302 3.654 1.00 10.82 ? 278 SER A O 1 ATOM 2121 C CB . SER A 1 278 ? 37.144 -13.633 6.526 1.00 10.78 ? 278 SER A CB 1 ATOM 2122 O OG . SER A 1 278 ? 36.452 -14.728 5.917 1.00 9.11 ? 278 SER A OG 1 ATOM 2123 N N . PRO A 1 279 ? 39.929 -14.394 5.448 1.00 11.01 ? 279 PRO A N 1 ATOM 2124 C CA . PRO A 1 279 ? 40.808 -15.391 4.847 1.00 11.77 ? 279 PRO A CA 1 ATOM 2125 C C . PRO A 1 279 ? 40.089 -16.606 4.328 1.00 12.45 ? 279 PRO A C 1 ATOM 2126 O O . PRO A 1 279 ? 40.527 -17.098 3.280 1.00 13.59 ? 279 PRO A O 1 ATOM 2127 C CB . PRO A 1 279 ? 41.752 -15.810 6.000 1.00 11.94 ? 279 PRO A CB 1 ATOM 2128 C CG . PRO A 1 279 ? 41.767 -14.639 6.916 1.00 12.29 ? 279 PRO A CG 1 ATOM 2129 C CD . PRO A 1 279 ? 40.400 -13.989 6.775 1.00 11.35 ? 279 PRO A CD 1 ATOM 2130 N N . THR A 1 280 ? 39.075 -17.102 5.036 1.00 11.64 ? 280 THR A N 1 ATOM 2131 C CA . THR A 1 280 ? 38.332 -18.261 4.572 1.00 12.13 ? 280 THR A CA 1 ATOM 2132 C C . THR A 1 280 ? 37.055 -17.966 3.755 1.00 12.79 ? 280 THR A C 1 ATOM 2133 O O . THR A 1 280 ? 36.420 -18.940 3.309 1.00 13.14 ? 280 THR A O 1 ATOM 2134 C CB . THR A 1 280 ? 37.922 -19.165 5.764 1.00 11.71 ? 280 THR A CB 1 ATOM 2135 O OG1 . THR A 1 280 ? 37.103 -18.406 6.662 1.00 12.68 ? 280 THR A OG1 1 ATOM 2136 C CG2 . THR A 1 280 ? 39.153 -19.565 6.601 1.00 10.76 ? 280 THR A CG2 1 ATOM 2137 N N . SER A 1 281 ? 36.668 -16.690 3.578 1.00 11.17 ? 281 SER A N 1 ATOM 2138 C CA . SER A 1 281 ? 35.491 -16.301 2.764 1.00 12.52 ? 281 SER A CA 1 ATOM 2139 C C . SER A 1 281 ? 34.114 -16.670 3.263 1.00 12.17 ? 281 SER A C 1 ATOM 2140 O O . SER A 1 281 ? 33.132 -16.392 2.560 1.00 12.37 ? 281 SER A O 1 ATOM 2141 C CB . SER A 1 281 ? 35.549 -16.767 1.307 1.00 13.20 ? 281 SER A CB 1 ATOM 2142 O OG . SER A 1 281 ? 36.842 -16.482 0.758 1.00 15.84 ? 281 SER A OG 1 ATOM 2143 N N . ASN A 1 282 ? 34.035 -17.255 4.455 1.00 11.62 ? 282 ASN A N 1 ATOM 2144 C CA . ASN A 1 282 ? 32.741 -17.702 4.996 1.00 12.41 ? 282 ASN A CA 1 ATOM 2145 C C . ASN A 1 282 ? 32.211 -16.847 6.130 1.00 11.24 ? 282 ASN A C 1 ATOM 2146 O O . ASN A 1 282 ? 31.326 -17.280 6.875 1.00 12.70 ? 282 ASN A O 1 ATOM 2147 C CB . ASN A 1 282 ? 32.837 -19.165 5.474 1.00 13.00 ? 282 ASN A CB 1 ATOM 2148 C CG . ASN A 1 282 ? 33.689 -19.306 6.742 1.00 14.01 ? 282 ASN A CG 1 ATOM 2149 O OD1 . ASN A 1 282 ? 34.482 -18.430 7.068 1.00 14.82 ? 282 ASN A OD1 1 ATOM 2150 N ND2 . ASN A 1 282 ? 33.527 -20.418 7.448 1.00 14.50 ? 282 ASN A ND2 1 ATOM 2151 N N . GLN A 1 283 ? 32.731 -15.637 6.270 1.00 10.46 ? 283 GLN A N 1 ATOM 2152 C CA . GLN A 1 283 ? 32.297 -14.724 7.332 1.00 10.94 ? 283 GLN A CA 1 ATOM 2153 C C . GLN A 1 283 ? 31.379 -13.625 6.815 1.00 11.25 ? 283 GLN A C 1 ATOM 2154 O O . GLN A 1 283 ? 31.198 -13.501 5.590 1.00 10.84 ? 283 GLN A O 1 ATOM 2155 C CB . GLN A 1 283 ? 33.523 -14.089 7.980 1.00 10.69 ? 283 GLN A CB 1 ATOM 2156 C CG . GLN A 1 283 ? 34.528 -15.130 8.464 1.00 9.73 ? 283 GLN A CG 1 ATOM 2157 C CD . GLN A 1 283 ? 34.075 -15.758 9.739 1.00 8.31 ? 283 GLN A CD 1 ATOM 2158 O OE1 . GLN A 1 283 ? 33.875 -15.071 10.734 1.00 8.05 ? 283 GLN A OE1 1 ATOM 2159 N NE2 . GLN A 1 283 ? 33.902 -17.054 9.726 1.00 8.44 ? 283 GLN A NE2 1 ATOM 2160 N N . GLN A 1 284 ? 30.776 -12.824 7.712 1.00 11.15 ? 284 GLN A N 1 ATOM 2161 C CA . GLN A 1 284 ? 29.961 -11.737 7.200 1.00 11.87 ? 284 GLN A CA 1 ATOM 2162 C C . GLN A 1 284 ? 30.878 -10.719 6.551 1.00 11.40 ? 284 GLN A C 1 ATOM 2163 O O . GLN A 1 284 ? 32.021 -10.545 6.976 1.00 9.64 ? 284 GLN A O 1 ATOM 2164 C CB . GLN A 1 284 ? 29.132 -11.060 8.271 1.00 13.03 ? 284 GLN A CB 1 ATOM 2165 C CG . GLN A 1 284 ? 29.904 -10.160 9.165 1.00 17.18 ? 284 GLN A CG 1 ATOM 2166 C CD . GLN A 1 284 ? 29.068 -9.809 10.432 1.00 20.91 ? 284 GLN A CD 1 ATOM 2167 O OE1 . GLN A 1 284 ? 28.953 -10.629 11.341 1.00 23.43 ? 284 GLN A OE1 1 ATOM 2168 N NE2 . GLN A 1 284 ? 28.489 -8.629 10.456 1.00 21.67 ? 284 GLN A NE2 1 ATOM 2169 N N . ASP A 1 285 ? 30.371 -10.051 5.519 1.00 10.28 ? 285 ASP A N 1 ATOM 2170 C CA . ASP A 1 285 ? 31.200 -9.134 4.766 1.00 9.97 ? 285 ASP A CA 1 ATOM 2171 C C . ASP A 1 285 ? 31.066 -7.758 5.366 1.00 10.03 ? 285 ASP A C 1 ATOM 2172 O O . ASP A 1 285 ? 30.446 -7.584 6.423 1.00 9.43 ? 285 ASP A O 1 ATOM 2173 C CB . ASP A 1 285 ? 30.796 -9.163 3.295 1.00 9.12 ? 285 ASP A CB 1 ATOM 2174 C CG . ASP A 1 285 ? 31.892 -8.631 2.372 1.00 10.23 ? 285 ASP A CG 1 ATOM 2175 O OD1 . ASP A 1 285 ? 32.997 -8.227 2.853 1.00 10.29 ? 285 ASP A OD1 1 ATOM 2176 O OD2 . ASP A 1 285 ? 31.713 -8.564 1.136 1.00 7.00 ? 285 ASP A OD2 1 ATOM 2177 N N . CYS A 1 286 ? 31.677 -6.785 4.709 1.00 9.62 ? 286 CYS A N 1 ATOM 2178 C CA . CYS A 1 286 ? 31.703 -5.423 5.206 1.00 9.81 ? 286 CYS A CA 1 ATOM 2179 C C . CYS A 1 286 ? 31.574 -4.494 4.003 1.00 9.95 ? 286 CYS A C 1 ATOM 2180 O O . CYS A 1 286 ? 31.912 -4.861 2.861 1.00 7.85 ? 286 CYS A O 1 ATOM 2181 C CB . CYS A 1 286 ? 33.038 -5.150 5.926 1.00 9.96 ? 286 CYS A CB 1 ATOM 2182 S SG . CYS A 1 286 ? 33.283 -3.469 6.660 1.00 12.41 ? 286 CYS A SG 1 ATOM 2183 N N . GLN A 1 287 ? 31.064 -3.301 4.274 1.00 9.97 ? 287 GLN A N 1 ATOM 2184 C CA . GLN A 1 287 ? 31.009 -2.232 3.284 1.00 10.23 ? 287 GLN A CA 1 ATOM 2185 C C . GLN A 1 287 ? 32.421 -1.837 2.807 1.00 9.49 ? 287 GLN A C 1 ATOM 2186 O O . GLN A 1 287 ? 33.394 -2.004 3.540 1.00 8.76 ? 287 GLN A O 1 ATOM 2187 C CB . GLN A 1 287 ? 30.270 -1.026 3.898 1.00 9.57 ? 287 GLN A CB 1 ATOM 2188 C CG . GLN A 1 287 ? 30.266 0.215 3.037 1.00 8.22 ? 287 GLN A CG 1 ATOM 2189 C CD . GLN A 1 287 ? 31.456 1.119 3.295 1.00 10.57 ? 287 GLN A CD 1 ATOM 2190 O OE1 . GLN A 1 287 ? 32.256 0.875 4.206 1.00 11.84 ? 287 GLN A OE1 1 ATOM 2191 N NE2 . GLN A 1 287 ? 31.596 2.157 2.474 1.00 10.55 ? 287 GLN A NE2 1 ATOM 2192 N N . SER A 1 288 ? 32.505 -1.333 1.575 1.00 10.13 ? 288 SER A N 1 ATOM 2193 C CA . SER A 1 288 ? 33.746 -0.877 0.955 1.00 10.56 ? 288 SER A CA 1 ATOM 2194 C C . SER A 1 288 ? 33.478 0.404 0.236 1.00 11.39 ? 288 SER A C 1 ATOM 2195 O O . SER A 1 288 ? 32.400 0.561 -0.332 1.00 11.70 ? 288 SER A O 1 ATOM 2196 C CB . SER A 1 288 ? 34.189 -1.854 -0.123 1.00 10.18 ? 288 SER A CB 1 ATOM 2197 O OG . SER A 1 288 ? 34.571 -3.070 0.480 1.00 11.69 ? 288 SER A OG 1 ATOM 2198 N N . SER A 1 289 ? 34.465 1.306 0.210 1.00 11.41 ? 289 SER A N 1 ATOM 2199 C CA . SER A 1 289 ? 34.293 2.490 -0.612 1.00 10.29 ? 289 SER A CA 1 ATOM 2200 C C . SER A 1 289 ? 34.970 2.087 -1.882 1.00 9.38 ? 289 SER A C 1 ATOM 2201 O O . SER A 1 289 ? 35.929 1.328 -1.829 1.00 8.01 ? 289 SER A O 1 ATOM 2202 C CB . SER A 1 289 ? 34.973 3.709 0.016 1.00 11.12 ? 289 SER A CB 1 ATOM 2203 O OG . SER A 1 289 ? 36.400 3.559 0.075 1.00 13.23 ? 289 SER A OG 1 ATOM 2204 N N . PHE A 1 290 ? 34.498 2.615 -3.007 1.00 9.26 ? 290 PHE A N 1 ATOM 2205 C CA . PHE A 1 290 ? 35.007 2.289 -4.347 1.00 9.59 ? 290 PHE A CA 1 ATOM 2206 C C . PHE A 1 290 ? 34.882 3.601 -5.133 1.00 10.42 ? 290 PHE A C 1 ATOM 2207 O O . PHE A 1 290 ? 33.774 4.047 -5.455 1.00 10.27 ? 290 PHE A O 1 ATOM 2208 C CB . PHE A 1 290 ? 34.120 1.203 -4.921 1.00 9.04 ? 290 PHE A CB 1 ATOM 2209 C CG . PHE A 1 290 ? 34.648 0.530 -6.155 1.00 9.13 ? 290 PHE A CG 1 ATOM 2210 C CD1 . PHE A 1 290 ? 35.970 0.148 -6.269 1.00 8.46 ? 290 PHE A CD1 1 ATOM 2211 C CD2 . PHE A 1 290 ? 33.768 0.202 -7.189 1.00 9.76 ? 290 PHE A CD2 1 ATOM 2212 C CE1 . PHE A 1 290 ? 36.400 -0.532 -7.420 1.00 8.10 ? 290 PHE A CE1 1 ATOM 2213 C CE2 . PHE A 1 290 ? 34.200 -0.469 -8.331 1.00 9.47 ? 290 PHE A CE2 1 ATOM 2214 C CZ . PHE A 1 290 ? 35.506 -0.825 -8.447 1.00 8.14 ? 290 PHE A CZ 1 ATOM 2215 N N . VAL A 1 291 ? 36.020 4.237 -5.407 1.00 9.72 ? 291 VAL A N 1 ATOM 2216 C CA . VAL A 1 291 ? 35.996 5.587 -5.907 1.00 10.74 ? 291 VAL A CA 1 ATOM 2217 C C . VAL A 1 291 ? 37.014 5.744 -7.026 1.00 10.99 ? 291 VAL A C 1 ATOM 2218 O O . VAL A 1 291 ? 38.145 5.247 -6.919 1.00 10.31 ? 291 VAL A O 1 ATOM 2219 C CB . VAL A 1 291 ? 36.351 6.559 -4.727 1.00 11.61 ? 291 VAL A CB 1 ATOM 2220 C CG1 . VAL A 1 291 ? 36.691 7.945 -5.209 1.00 13.67 ? 291 VAL A CG1 1 ATOM 2221 C CG2 . VAL A 1 291 ? 35.206 6.617 -3.699 1.00 10.56 ? 291 VAL A CG2 1 ATOM 2222 N N . ALA A 1 292 ? 36.601 6.390 -8.112 1.00 11.32 ? 292 ALA A N 1 ATOM 2223 C CA . ALA A 1 292 ? 37.522 6.698 -9.205 1.00 12.24 ? 292 ALA A CA 1 ATOM 2224 C C . ALA A 1 292 ? 38.174 8.055 -8.962 1.00 12.93 ? 292 ALA A C 1 ATOM 2225 O O . ALA A 1 292 ? 37.486 9.014 -8.576 1.00 13.86 ? 292 ALA A O 1 ATOM 2226 C CB . ALA A 1 292 ? 36.783 6.705 -10.542 1.00 12.52 ? 292 ALA A CB 1 ATOM 2227 N N . VAL A 1 293 ? 39.482 8.138 -9.195 1.00 12.82 ? 293 VAL A N 1 ATOM 2228 C CA . VAL A 1 293 ? 40.262 9.367 -9.018 1.00 13.05 ? 293 VAL A CA 1 ATOM 2229 C C . VAL A 1 293 ? 41.327 9.434 -10.111 1.00 13.94 ? 293 VAL A C 1 ATOM 2230 O O . VAL A 1 293 ? 41.530 8.476 -10.852 1.00 14.91 ? 293 VAL A O 1 ATOM 2231 C CB . VAL A 1 293 ? 40.994 9.436 -7.656 1.00 12.87 ? 293 VAL A CB 1 ATOM 2232 C CG1 . VAL A 1 293 ? 40.018 9.288 -6.472 1.00 12.69 ? 293 VAL A CG1 1 ATOM 2233 C CG2 . VAL A 1 293 ? 42.110 8.351 -7.577 1.00 12.11 ? 293 VAL A CG2 1 ATOM 2234 N N . THR A 1 294 ? 42.017 10.568 -10.214 1.00 14.42 ? 294 THR A N 1 ATOM 2235 C CA . THR A 1 294 ? 43.063 10.711 -11.207 1.00 14.57 ? 294 THR A CA 1 ATOM 2236 C C . THR A 1 294 ? 44.302 11.065 -10.439 1.00 15.36 ? 294 THR A C 1 ATOM 2237 O O . THR A 1 294 ? 44.304 12.035 -9.687 1.00 14.81 ? 294 THR A O 1 ATOM 2238 C CB . THR A 1 294 ? 42.732 11.807 -12.217 1.00 14.95 ? 294 THR A CB 1 ATOM 2239 O OG1 . THR A 1 294 ? 41.591 11.410 -12.967 1.00 13.89 ? 294 THR A OG1 1 ATOM 2240 C CG2 . THR A 1 294 ? 43.838 11.954 -13.298 1.00 12.78 ? 294 THR A CG2 1 ATOM 2241 N N . ILE A 1 295 ? 45.337 10.244 -10.597 1.00 15.34 ? 295 ILE A N 1 ATOM 2242 C CA . ILE A 1 295 ? 46.582 10.456 -9.902 1.00 16.42 ? 295 ILE A CA 1 ATOM 2243 C C . ILE A 1 295 ? 47.743 10.503 -10.886 1.00 17.25 ? 295 ILE A C 1 ATOM 2244 O O . ILE A 1 295 ? 47.924 9.628 -11.713 1.00 15.86 ? 295 ILE A O 1 ATOM 2245 C CB . ILE A 1 295 ? 46.818 9.403 -8.830 1.00 16.96 ? 295 ILE A CB 1 ATOM 2246 C CG1 . ILE A 1 295 ? 45.735 9.468 -7.745 1.00 16.71 ? 295 ILE A CG1 1 ATOM 2247 C CG2 . ILE A 1 295 ? 48.167 9.677 -8.138 1.00 19.16 ? 295 ILE A CG2 1 ATOM 2248 C CD1 . ILE A 1 295 ? 45.718 8.241 -6.823 1.00 16.73 ? 295 ILE A CD1 1 ATOM 2249 N N . GLU A 1 296 ? 48.510 11.585 -10.794 1.00 19.95 ? 296 GLU A N 1 ATOM 2250 C CA . GLU A 1 296 ? 49.648 11.807 -11.666 1.00 21.51 ? 296 GLU A CA 1 ATOM 2251 C C . GLU A 1 296 ? 49.198 11.629 -13.125 1.00 21.50 ? 296 GLU A C 1 ATOM 2252 O O . GLU A 1 296 ? 49.832 10.947 -13.956 1.00 22.01 ? 296 GLU A O 1 ATOM 2253 C CB . GLU A 1 296 ? 50.766 10.853 -11.272 1.00 22.36 ? 296 GLU A CB 1 ATOM 2254 C CG . GLU A 1 296 ? 52.136 11.399 -11.633 1.00 27.97 ? 296 GLU A CG 1 ATOM 2255 C CD . GLU A 1 296 ? 52.860 12.052 -10.485 1.00 29.55 ? 296 GLU A CD 1 ATOM 2256 O OE1 . GLU A 1 296 ? 54.087 12.148 -10.603 1.00 36.68 ? 296 GLU A OE1 1 ATOM 2257 O OE2 . GLU A 1 296 ? 52.248 12.455 -9.487 1.00 30.46 ? 296 GLU A OE2 1 ATOM 2258 N N . GLY A 1 297 ? 48.043 12.202 -13.419 1.00 21.00 ? 297 GLY A N 1 ATOM 2259 C CA . GLY A 1 297 ? 47.518 12.167 -14.766 1.00 20.38 ? 297 GLY A CA 1 ATOM 2260 C C . GLY A 1 297 ? 46.844 10.881 -15.196 1.00 20.08 ? 297 GLY A C 1 ATOM 2261 O O . GLY A 1 297 ? 46.312 10.831 -16.296 1.00 21.53 ? 297 GLY A O 1 ATOM 2262 N N . LYS A 1 298 ? 46.836 9.856 -14.353 1.00 17.53 ? 298 LYS A N 1 ATOM 2263 C CA . LYS A 1 298 ? 46.208 8.603 -14.736 1.00 16.68 ? 298 LYS A CA 1 ATOM 2264 C C . LYS A 1 298 ? 44.954 8.289 -13.887 1.00 15.38 ? 298 LYS A C 1 ATOM 2265 O O . LYS A 1 298 ? 44.956 8.465 -12.687 1.00 14.30 ? 298 LYS A O 1 ATOM 2266 C CB . LYS A 1 298 ? 47.228 7.457 -14.680 1.00 16.37 ? 298 LYS A CB 1 ATOM 2267 C CG . LYS A 1 298 ? 46.602 6.105 -14.894 1.00 20.11 ? 298 LYS A CG 1 ATOM 2268 C CD . LYS A 1 298 ? 47.632 4.972 -14.916 1.00 27.18 ? 298 LYS A CD 1 ATOM 2269 C CE . LYS A 1 298 ? 47.212 3.921 -15.938 1.00 32.84 ? 298 LYS A CE 1 ATOM 2270 N NZ . LYS A 1 298 ? 47.680 2.573 -15.509 1.00 38.15 ? 298 LYS A NZ 1 ATOM 2271 N N . ARG A 1 299 ? 43.888 7.839 -14.538 1.00 14.51 ? 299 ARG A N 1 ATOM 2272 C CA . ARG A 1 299 ? 42.649 7.484 -13.871 1.00 14.66 ? 299 ARG A CA 1 ATOM 2273 C C . ARG A 1 299 ? 42.842 6.132 -13.216 1.00 13.38 ? 299 ARG A C 1 ATOM 2274 O O . ARG A 1 299 ? 43.287 5.199 -13.870 1.00 12.85 ? 299 ARG A O 1 ATOM 2275 C CB . ARG A 1 299 ? 41.546 7.376 -14.939 1.00 15.48 ? 299 ARG A CB 1 ATOM 2276 C CG . ARG A 1 299 ? 40.136 7.592 -14.435 1.00 20.59 ? 299 ARG A CG 1 ATOM 2277 C CD . ARG A 1 299 ? 39.994 8.800 -13.541 1.00 24.41 ? 299 ARG A CD 1 ATOM 2278 N NE . ARG A 1 299 ? 38.612 9.097 -13.158 1.00 27.51 ? 299 ARG A NE 1 ATOM 2279 C CZ . ARG A 1 299 ? 38.283 10.173 -12.441 1.00 26.74 ? 299 ARG A CZ 1 ATOM 2280 N NH1 . ARG A 1 299 ? 39.227 11.007 -12.065 1.00 23.51 ? 299 ARG A NH1 1 ATOM 2281 N NH2 . ARG A 1 299 ? 37.025 10.416 -12.102 1.00 27.55 ? 299 ARG A NH2 1 ATOM 2282 N N . VAL A 1 300 ? 42.528 6.018 -11.930 1.00 11.79 ? 300 VAL A N 1 ATOM 2283 C CA . VAL A 1 300 ? 42.631 4.724 -11.256 1.00 11.00 ? 300 VAL A CA 1 ATOM 2284 C C . VAL A 1 300 ? 41.433 4.585 -10.326 1.00 11.56 ? 300 VAL A C 1 ATOM 2285 O O . VAL A 1 300 ? 40.657 5.509 -10.156 1.00 11.15 ? 300 VAL A O 1 ATOM 2286 C CB . VAL A 1 300 ? 43.936 4.545 -10.417 1.00 11.68 ? 300 VAL A CB 1 ATOM 2287 C CG1 . VAL A 1 300 ? 45.216 4.458 -11.326 1.00 9.85 ? 300 VAL A CG1 1 ATOM 2288 C CG2 . VAL A 1 300 ? 44.078 5.663 -9.373 1.00 9.22 ? 300 VAL A CG2 1 ATOM 2289 N N . MET A 1 301 ? 41.276 3.407 -9.745 1.00 11.17 ? 301 MET A N 1 ATOM 2290 C CA . MET A 1 301 ? 40.184 3.151 -8.832 1.00 10.56 ? 301 MET A CA 1 ATOM 2291 C C . MET A 1 301 ? 40.749 2.853 -7.442 1.00 9.77 ? 301 MET A C 1 ATOM 2292 O O . MET A 1 301 ? 41.729 2.108 -7.315 1.00 9.74 ? 301 MET A O 1 ATOM 2293 C CB . MET A 1 301 ? 39.394 1.951 -9.326 1.00 9.25 ? 301 MET A CB 1 ATOM 2294 C CG . MET A 1 301 ? 38.629 2.223 -10.596 1.00 12.42 ? 301 MET A CG 1 ATOM 2295 S SD . MET A 1 301 ? 37.753 0.735 -11.131 1.00 15.44 ? 301 MET A SD 1 ATOM 2296 C CE . MET A 1 301 ? 38.890 0.040 -12.190 1.00 12.21 ? 301 MET A CE 1 ATOM 2297 N N . LEU A 1 302 ? 40.123 3.414 -6.415 1.00 9.27 ? 302 LEU A N 1 ATOM 2298 C CA . LEU A 1 302 ? 40.504 3.131 -5.044 1.00 9.21 ? 302 LEU A CA 1 ATOM 2299 C C . LEU A 1 302 ? 39.436 2.265 -4.379 1.00 8.72 ? 302 LEU A C 1 ATOM 2300 O O . LEU A 1 302 ? 38.227 2.550 -4.490 1.00 8.12 ? 302 LEU A O 1 ATOM 2301 C CB . LEU A 1 302 ? 40.626 4.422 -4.263 1.00 9.91 ? 302 LEU A CB 1 ATOM 2302 C CG . LEU A 1 302 ? 41.601 5.427 -4.854 1.00 11.43 ? 302 LEU A CG 1 ATOM 2303 C CD1 . LEU A 1 302 ? 41.793 6.569 -3.861 1.00 10.49 ? 302 LEU A CD1 1 ATOM 2304 C CD2 . LEU A 1 302 ? 42.927 4.774 -5.223 1.00 11.00 ? 302 LEU A CD2 1 ATOM 2305 N N . PHE A 1 303 ? 39.888 1.236 -3.654 1.00 8.35 ? 303 PHE A N 1 ATOM 2306 C CA . PHE A 1 303 ? 38.987 0.324 -2.989 1.00 8.72 ? 303 PHE A CA 1 ATOM 2307 C C . PHE A 1 303 ? 39.431 0.093 -1.544 1.00 9.40 ? 303 PHE A C 1 ATOM 2308 O O . PHE A 1 303 ? 40.596 -0.198 -1.291 1.00 11.06 ? 303 PHE A O 1 ATOM 2309 C CB . PHE A 1 303 ? 38.962 -1.018 -3.772 1.00 7.96 ? 303 PHE A CB 1 ATOM 2310 C CG . PHE A 1 303 ? 38.175 -2.147 -3.089 1.00 7.95 ? 303 PHE A CG 1 ATOM 2311 C CD1 . PHE A 1 303 ? 36.791 -2.197 -3.151 1.00 9.85 ? 303 PHE A CD1 1 ATOM 2312 C CD2 . PHE A 1 303 ? 38.820 -3.154 -2.449 1.00 8.57 ? 303 PHE A CD2 1 ATOM 2313 C CE1 . PHE A 1 303 ? 36.047 -3.248 -2.559 1.00 10.50 ? 303 PHE A CE1 1 ATOM 2314 C CE2 . PHE A 1 303 ? 38.101 -4.196 -1.831 1.00 11.35 ? 303 PHE A CE2 1 ATOM 2315 C CZ . PHE A 1 303 ? 36.714 -4.254 -1.896 1.00 10.76 ? 303 PHE A CZ 1 ATOM 2316 N N . THR A 1 304 ? 38.525 0.190 -0.585 1.00 9.34 ? 304 THR A N 1 ATOM 2317 C CA . THR A 1 304 ? 38.936 -0.100 0.794 1.00 10.80 ? 304 THR A CA 1 ATOM 2318 C C . THR A 1 304 ? 38.132 -1.262 1.336 1.00 10.90 ? 304 THR A C 1 ATOM 2319 O O . THR A 1 304 ? 36.946 -1.430 1.022 1.00 11.00 ? 304 THR A O 1 ATOM 2320 C CB . THR A 1 304 ? 38.700 1.085 1.740 1.00 11.37 ? 304 THR A CB 1 ATOM 2321 O OG1 . THR A 1 304 ? 37.323 1.481 1.657 1.00 10.76 ? 304 THR A OG1 1 ATOM 2322 C CG2 . THR A 1 304 ? 39.536 2.296 1.305 1.00 10.26 ? 304 THR A CG2 1 ATOM 2323 N N . HIS A 1 305 ? 38.764 -2.028 2.206 1.00 9.83 ? 305 HIS A N 1 ATOM 2324 C CA . HIS A 1 305 ? 38.132 -3.174 2.824 1.00 9.90 ? 305 HIS A CA 1 ATOM 2325 C C . HIS A 1 305 ? 39.028 -3.761 3.920 1.00 10.00 ? 305 HIS A C 1 ATOM 2326 O O . HIS A 1 305 ? 40.246 -3.825 3.780 1.00 10.22 ? 305 HIS A O 1 ATOM 2327 C CB . HIS A 1 305 ? 37.861 -4.257 1.777 1.00 9.44 ? 305 HIS A CB 1 ATOM 2328 C CG . HIS A 1 305 ? 36.921 -5.318 2.249 1.00 11.44 ? 305 HIS A CG 1 ATOM 2329 N ND1 . HIS A 1 305 ? 35.662 -5.493 1.713 1.00 13.16 ? 305 HIS A ND1 1 ATOM 2330 C CD2 . HIS A 1 305 ? 37.034 -6.238 3.243 1.00 15.26 ? 305 HIS A CD2 1 ATOM 2331 C CE1 . HIS A 1 305 ? 35.052 -6.486 2.337 1.00 12.23 ? 305 HIS A CE1 1 ATOM 2332 N NE2 . HIS A 1 305 ? 35.858 -6.946 3.277 1.00 14.45 ? 305 HIS A NE2 1 ATOM 2333 N N . PRO A 1 306 ? 38.420 -4.192 5.011 1.00 9.72 ? 306 PRO A N 1 ATOM 2334 C CA . PRO A 1 306 ? 39.157 -4.856 6.089 1.00 10.02 ? 306 PRO A CA 1 ATOM 2335 C C . PRO A 1 306 ? 39.659 -6.263 5.708 1.00 10.57 ? 306 PRO A C 1 ATOM 2336 O O . PRO A 1 306 ? 38.996 -6.923 4.871 1.00 10.58 ? 306 PRO A O 1 ATOM 2337 C CB . PRO A 1 306 ? 38.096 -5.001 7.171 1.00 10.04 ? 306 PRO A CB 1 ATOM 2338 C CG . PRO A 1 306 ? 37.058 -3.920 6.799 1.00 9.74 ? 306 PRO A CG 1 ATOM 2339 C CD . PRO A 1 306 ? 36.999 -3.991 5.322 1.00 8.53 ? 306 PRO A CD 1 ATOM 2340 N N . LEU A 1 307 ? 40.770 -6.717 6.309 1.00 10.16 ? 307 LEU A N 1 ATOM 2341 C CA . LEU A 1 307 ? 41.165 -8.117 6.160 1.00 11.31 ? 307 LEU A CA 1 ATOM 2342 C C . LEU A 1 307 ? 40.269 -8.990 7.038 1.00 11.59 ? 307 LEU A C 1 ATOM 2343 O O . LEU A 1 307 ? 39.954 -10.126 6.664 1.00 12.24 ? 307 LEU A O 1 ATOM 2344 C CB . LEU A 1 307 ? 42.633 -8.369 6.516 1.00 10.84 ? 307 LEU A CB 1 ATOM 2345 C CG . LEU A 1 307 ? 43.627 -7.616 5.640 1.00 13.61 ? 307 LEU A CG 1 ATOM 2346 C CD1 . LEU A 1 307 ? 45.087 -8.066 5.933 1.00 16.12 ? 307 LEU A CD1 1 ATOM 2347 C CD2 . LEU A 1 307 ? 43.267 -7.787 4.149 1.00 15.04 ? 307 LEU A CD2 1 ATOM 2348 N N . ASN A 1 308 ? 39.840 -8.465 8.185 1.00 11.15 ? 308 ASN A N 1 ATOM 2349 C CA . ASN A 1 308 ? 38.936 -9.204 9.052 1.00 11.68 ? 308 ASN A CA 1 ATOM 2350 C C . ASN A 1 308 ? 39.530 -10.566 9.435 1.00 11.14 ? 308 ASN A C 1 ATOM 2351 O O . ASN A 1 308 ? 38.846 -11.580 9.328 1.00 10.10 ? 308 ASN A O 1 ATOM 2352 C CB . ASN A 1 308 ? 37.554 -9.408 8.362 1.00 11.66 ? 308 ASN A CB 1 ATOM 2353 C CG . ASN A 1 308 ? 36.459 -9.885 9.342 1.00 12.72 ? 308 ASN A CG 1 ATOM 2354 O OD1 . ASN A 1 308 ? 36.487 -9.545 10.537 1.00 12.46 ? 308 ASN A OD1 1 ATOM 2355 N ND2 . ASN A 1 308 ? 35.464 -10.617 8.831 1.00 7.76 ? 308 ASN A ND2 1 ATOM 2356 N N . LEU A 1 309 ? 40.788 -10.564 9.879 1.00 11.49 ? 309 LEU A N 1 ATOM 2357 C CA . LEU A 1 309 ? 41.488 -11.788 10.304 1.00 12.39 ? 309 LEU A CA 1 ATOM 2358 C C . LEU A 1 309 ? 40.831 -12.316 11.561 1.00 13.84 ? 309 LEU A C 1 ATOM 2359 O O . LEU A 1 309 ? 40.916 -13.515 11.866 1.00 14.89 ? 309 LEU A O 1 ATOM 2360 C CB . LEU A 1 309 ? 42.996 -11.563 10.549 1.00 11.28 ? 309 LEU A CB 1 ATOM 2361 C CG . LEU A 1 309 ? 43.877 -11.135 9.351 1.00 13.42 ? 309 LEU A CG 1 ATOM 2362 C CD1 . LEU A 1 309 ? 45.361 -11.346 9.669 1.00 13.93 ? 309 LEU A CD1 1 ATOM 2363 C CD2 . LEU A 1 309 ? 43.563 -11.864 7.979 1.00 9.49 ? 309 LEU A CD2 1 ATOM 2364 N N . LYS A 1 310 ? 40.146 -11.434 12.282 1.00 14.87 ? 310 LYS A N 1 ATOM 2365 C CA . LYS A 1 310 ? 39.471 -11.847 13.500 1.00 15.80 ? 310 LYS A CA 1 ATOM 2366 C C . LYS A 1 310 ? 38.083 -12.443 13.195 1.00 16.68 ? 310 LYS A C 1 ATOM 2367 O O . LYS A 1 310 ? 37.525 -13.163 14.017 1.00 17.12 ? 310 LYS A O 1 ATOM 2368 C CB . LYS A 1 310 ? 39.309 -10.679 14.480 1.00 15.88 ? 310 LYS A CB 1 ATOM 2369 C CG . LYS A 1 310 ? 40.590 -9.992 14.915 1.00 16.76 ? 310 LYS A CG 1 ATOM 2370 C CD . LYS A 1 310 ? 40.248 -8.792 15.861 1.00 16.70 ? 310 LYS A CD 1 ATOM 2371 C CE . LYS A 1 310 ? 41.498 -8.066 16.393 1.00 17.93 ? 310 LYS A CE 1 ATOM 2372 N NZ . LYS A 1 310 ? 41.048 -6.771 17.099 1.00 18.30 ? 310 LYS A NZ 1 ATOM 2373 N N . GLY A 1 311 ? 37.496 -12.107 12.051 1.00 15.44 ? 311 GLY A N 1 ATOM 2374 C CA . GLY A 1 311 ? 36.227 -12.715 11.701 1.00 14.64 ? 311 GLY A CA 1 ATOM 2375 C C . GLY A 1 311 ? 35.021 -11.984 12.228 1.00 13.91 ? 311 GLY A C 1 ATOM 2376 O O . GLY A 1 311 ? 35.145 -11.026 12.996 1.00 13.78 ? 311 GLY A O 1 ATOM 2377 N N . ARG A 1 312 ? 33.862 -12.434 11.784 1.00 12.69 ? 312 ARG A N 1 ATOM 2378 C CA . ARG A 1 312 ? 32.605 -11.842 12.174 1.00 13.55 ? 312 ARG A CA 1 ATOM 2379 C C . ARG A 1 312 ? 32.593 -10.342 11.903 1.00 13.69 ? 312 ARG A C 1 ATOM 2380 O O . ARG A 1 312 ? 33.013 -9.937 10.821 1.00 13.22 ? 312 ARG A O 1 ATOM 2381 C CB . ARG A 1 312 ? 32.228 -12.235 13.608 1.00 12.94 ? 312 ARG A CB 1 ATOM 2382 C CG . ARG A 1 312 ? 31.976 -13.780 13.703 1.00 13.92 ? 312 ARG A CG 1 ATOM 2383 C CD . ARG A 1 312 ? 31.549 -14.338 15.083 1.00 13.26 ? 312 ARG A CD 1 ATOM 2384 N NE . ARG A 1 312 ? 32.452 -13.844 16.111 1.00 9.00 ? 312 ARG A NE 1 ATOM 2385 C CZ . ARG A 1 312 ? 32.133 -13.636 17.382 1.00 11.23 ? 312 ARG A CZ 1 ATOM 2386 N NH1 . ARG A 1 312 ? 30.907 -13.895 17.855 1.00 6.34 ? 312 ARG A NH1 1 ATOM 2387 N NH2 . ARG A 1 312 ? 33.077 -13.169 18.202 1.00 9.93 ? 312 ARG A NH2 1 ATOM 2388 N N . TRP A 1 313 ? 32.131 -9.517 12.846 1.00 12.49 ? 313 TRP A N 1 ATOM 2389 C CA . TRP A 1 313 ? 32.033 -8.093 12.540 1.00 12.36 ? 313 TRP A CA 1 ATOM 2390 C C . TRP A 1 313 ? 33.269 -7.331 13.036 1.00 12.74 ? 313 TRP A C 1 ATOM 2391 O O . TRP A 1 313 ? 33.286 -6.096 13.009 1.00 12.90 ? 313 TRP A O 1 ATOM 2392 C CB . TRP A 1 313 ? 30.751 -7.508 13.182 1.00 12.63 ? 313 TRP A CB 1 ATOM 2393 C CG . TRP A 1 313 ? 30.877 -7.484 14.666 1.00 12.14 ? 313 TRP A CG 1 ATOM 2394 C CD1 . TRP A 1 313 ? 31.305 -6.439 15.435 1.00 11.38 ? 313 TRP A CD1 1 ATOM 2395 C CD2 . TRP A 1 313 ? 30.679 -8.583 15.557 1.00 12.07 ? 313 TRP A CD2 1 ATOM 2396 N NE1 . TRP A 1 313 ? 31.363 -6.813 16.754 1.00 13.50 ? 313 TRP A NE1 1 ATOM 2397 C CE2 . TRP A 1 313 ? 30.971 -8.124 16.859 1.00 12.42 ? 313 TRP A CE2 1 ATOM 2398 C CE3 . TRP A 1 313 ? 30.247 -9.904 15.392 1.00 14.27 ? 313 TRP A CE3 1 ATOM 2399 C CZ2 . TRP A 1 313 ? 30.849 -8.930 17.976 1.00 13.50 ? 313 TRP A CZ2 1 ATOM 2400 C CZ3 . TRP A 1 313 ? 30.137 -10.706 16.490 1.00 13.15 ? 313 TRP A CZ3 1 ATOM 2401 C CH2 . TRP A 1 313 ? 30.433 -10.219 17.776 1.00 15.02 ? 313 TRP A CH2 1 ATOM 2402 N N . MET A 1 314 ? 34.295 -8.025 13.528 1.00 11.56 ? 314 MET A N 1 ATOM 2403 C CA . MET A 1 314 ? 35.464 -7.270 14.030 1.00 13.56 ? 314 MET A CA 1 ATOM 2404 C C . MET A 1 314 ? 36.119 -6.381 12.928 1.00 12.70 ? 314 MET A C 1 ATOM 2405 O O . MET A 1 314 ? 36.530 -5.243 13.175 1.00 13.32 ? 314 MET A O 1 ATOM 2406 C CB . MET A 1 314 ? 36.547 -8.190 14.609 1.00 12.79 ? 314 MET A CB 1 ATOM 2407 C CG . MET A 1 314 ? 36.045 -9.313 15.366 1.00 20.34 ? 314 MET A CG 1 ATOM 2408 S SD . MET A 1 314 ? 34.979 -8.838 16.721 1.00 28.68 ? 314 MET A SD 1 ATOM 2409 C CE . MET A 1 314 ? 36.188 -8.014 17.566 1.00 25.61 ? 314 MET A CE 1 ATOM 2410 N N . ARG A 1 315 ? 36.269 -6.924 11.731 1.00 11.66 ? 315 ARG A N 1 ATOM 2411 C CA . ARG A 1 315 ? 36.736 -6.089 10.620 1.00 10.40 ? 315 ARG A CA 1 ATOM 2412 C C . ARG A 1 315 ? 38.042 -5.337 10.923 1.00 10.03 ? 315 ARG A C 1 ATOM 2413 O O . ARG A 1 315 ? 38.157 -4.137 10.693 1.00 8.78 ? 315 ARG A O 1 ATOM 2414 C CB . ARG A 1 315 ? 35.624 -5.101 10.254 1.00 10.02 ? 315 ARG A CB 1 ATOM 2415 C CG . ARG A 1 315 ? 34.468 -5.749 9.562 1.00 9.16 ? 315 ARG A CG 1 ATOM 2416 C CD . ARG A 1 315 ? 33.118 -5.032 9.754 1.00 10.78 ? 315 ARG A CD 1 ATOM 2417 N NE . ARG A 1 315 ? 32.001 -5.757 9.136 1.00 9.79 ? 315 ARG A NE 1 ATOM 2418 C CZ . ARG A 1 315 ? 30.719 -5.349 9.220 1.00 14.63 ? 315 ARG A CZ 1 ATOM 2419 N NH1 . ARG A 1 315 ? 30.425 -4.256 9.898 1.00 15.96 ? 315 ARG A NH1 1 ATOM 2420 N NH2 . ARG A 1 315 ? 29.724 -6.027 8.642 1.00 12.99 ? 315 ARG A NH2 1 ATOM 2421 N N . ASP A 1 316 ? 39.031 -6.068 11.395 1.00 9.35 ? 316 ASP A N 1 ATOM 2422 C CA . ASP A 1 316 ? 40.321 -5.507 11.632 1.00 10.60 ? 316 ASP A CA 1 ATOM 2423 C C . ASP A 1 316 ? 41.094 -5.375 10.313 1.00 10.24 ? 316 ASP A C 1 ATOM 2424 O O . ASP A 1 316 ? 40.772 -6.012 9.311 1.00 10.11 ? 316 ASP A O 1 ATOM 2425 C CB . ASP A 1 316 ? 41.109 -6.468 12.526 1.00 10.68 ? 316 ASP A CB 1 ATOM 2426 C CG . ASP A 1 316 ? 41.075 -7.868 11.994 1.00 12.07 ? 316 ASP A CG 1 ATOM 2427 O OD1 . ASP A 1 316 ? 42.110 -8.281 11.343 1.00 12.53 ? 316 ASP A OD1 1 ATOM 2428 O OD2 . ASP A 1 316 ? 40.056 -8.598 12.172 1.00 9.17 ? 316 ASP A OD2 1 ATOM 2429 N N . ARG A 1 317 ? 42.116 -4.546 10.356 1.00 10.01 ? 317 ARG A N 1 ATOM 2430 C CA . ARG A 1 317 ? 43.061 -4.327 9.252 1.00 12.42 ? 317 ARG A CA 1 ATOM 2431 C C . ARG A 1 317 ? 42.515 -3.804 7.947 1.00 11.40 ? 317 ARG A C 1 ATOM 2432 O O . ARG A 1 317 ? 42.541 -4.484 6.912 1.00 11.87 ? 317 ARG A O 1 ATOM 2433 C CB . ARG A 1 317 ? 43.879 -5.578 9.031 1.00 12.01 ? 317 ARG A CB 1 ATOM 2434 C CG . ARG A 1 317 ? 44.137 -6.196 10.371 1.00 17.05 ? 317 ARG A CG 1 ATOM 2435 C CD . ARG A 1 317 ? 45.094 -7.295 10.341 1.00 20.85 ? 317 ARG A CD 1 ATOM 2436 N NE . ARG A 1 317 ? 46.330 -6.629 10.356 1.00 28.07 ? 317 ARG A NE 1 ATOM 2437 C CZ . ARG A 1 317 ? 47.152 -6.697 11.376 1.00 32.75 ? 317 ARG A CZ 1 ATOM 2438 N NH1 . ARG A 1 317 ? 46.825 -7.483 12.435 1.00 31.14 ? 317 ARG A NH1 1 ATOM 2439 N NH2 . ARG A 1 317 ? 48.286 -5.995 11.306 1.00 27.40 ? 317 ARG A NH2 1 ATOM 2440 N N . LEU A 1 318 ? 42.062 -2.576 8.006 1.00 11.35 ? 318 LEU A N 1 ATOM 2441 C CA . LEU A 1 318 ? 41.486 -1.957 6.847 1.00 10.88 ? 318 LEU A CA 1 ATOM 2442 C C . LEU A 1 318 ? 42.603 -1.683 5.843 1.00 10.38 ? 318 LEU A C 1 ATOM 2443 O O . LEU A 1 318 ? 43.593 -1.040 6.167 1.00 9.82 ? 318 LEU A O 1 ATOM 2444 C CB . LEU A 1 318 ? 40.784 -0.693 7.305 1.00 10.55 ? 318 LEU A CB 1 ATOM 2445 C CG . LEU A 1 318 ? 40.150 0.142 6.198 1.00 13.33 ? 318 LEU A CG 1 ATOM 2446 C CD1 . LEU A 1 318 ? 38.978 -0.627 5.565 1.00 9.63 ? 318 LEU A CD1 1 ATOM 2447 C CD2 . LEU A 1 318 ? 39.696 1.514 6.774 1.00 11.90 ? 318 LEU A CD2 1 ATOM 2448 N N . HIS A 1 319 ? 42.460 -2.222 4.632 1.00 9.78 ? 319 HIS A N 1 ATOM 2449 C CA . HIS A 1 319 ? 43.434 -1.996 3.579 1.00 8.74 ? 319 HIS A CA 1 ATOM 2450 C C . HIS A 1 319 ? 42.883 -1.082 2.492 1.00 9.60 ? 319 HIS A C 1 ATOM 2451 O O . HIS A 1 319 ? 41.673 -0.880 2.358 1.00 8.70 ? 319 HIS A O 1 ATOM 2452 C CB . HIS A 1 319 ? 43.874 -3.318 2.950 1.00 9.26 ? 319 HIS A CB 1 ATOM 2453 C CG . HIS A 1 319 ? 45.092 -3.919 3.588 1.00 8.49 ? 319 HIS A CG 1 ATOM 2454 N ND1 . HIS A 1 319 ? 46.294 -4.016 2.930 1.00 5.82 ? 319 HIS A ND1 1 ATOM 2455 C CD2 . HIS A 1 319 ? 45.290 -4.443 4.825 1.00 7.12 ? 319 HIS A CD2 1 ATOM 2456 C CE1 . HIS A 1 319 ? 47.185 -4.586 3.731 1.00 9.30 ? 319 HIS A CE1 1 ATOM 2457 N NE2 . HIS A 1 319 ? 46.599 -4.860 4.886 1.00 8.57 ? 319 HIS A NE2 1 ATOM 2458 N N . LEU A 1 320 ? 43.816 -0.534 1.715 1.00 10.40 ? 320 LEU A N 1 ATOM 2459 C CA . LEU A 1 320 ? 43.496 0.315 0.577 1.00 9.24 ? 320 LEU A CA 1 ATOM 2460 C C . LEU A 1 320 ? 44.144 -0.287 -0.651 1.00 9.77 ? 320 LEU A C 1 ATOM 2461 O O . LEU A 1 320 ? 45.331 -0.611 -0.616 1.00 9.79 ? 320 LEU A O 1 ATOM 2462 C CB . LEU A 1 320 ? 44.052 1.724 0.786 1.00 9.02 ? 320 LEU A CB 1 ATOM 2463 C CG . LEU A 1 320 ? 44.095 2.651 -0.433 1.00 7.88 ? 320 LEU A CG 1 ATOM 2464 C CD1 . LEU A 1 320 ? 42.692 2.980 -0.968 1.00 3.96 ? 320 LEU A CD1 1 ATOM 2465 C CD2 . LEU A 1 320 ? 44.825 3.934 -0.043 1.00 8.71 ? 320 LEU A CD2 1 ATOM 2466 N N . TRP A 1 321 ? 43.377 -0.483 -1.726 1.00 9.36 ? 321 TRP A N 1 ATOM 2467 C CA . TRP A 1 321 ? 43.982 -0.986 -2.949 1.00 9.30 ? 321 TRP A CA 1 ATOM 2468 C C . TRP A 1 321 ? 43.745 0.029 -4.062 1.00 9.82 ? 321 TRP A C 1 ATOM 2469 O O . TRP A 1 321 ? 42.774 0.815 -4.020 1.00 9.50 ? 321 TRP A O 1 ATOM 2470 C CB . TRP A 1 321 ? 43.371 -2.325 -3.389 1.00 9.91 ? 321 TRP A CB 1 ATOM 2471 C CG . TRP A 1 321 ? 43.723 -3.615 -2.596 1.00 8.20 ? 321 TRP A CG 1 ATOM 2472 C CD1 . TRP A 1 321 ? 44.659 -4.584 -2.922 1.00 10.39 ? 321 TRP A CD1 1 ATOM 2473 C CD2 . TRP A 1 321 ? 43.083 -4.069 -1.421 1.00 9.50 ? 321 TRP A CD2 1 ATOM 2474 N NE1 . TRP A 1 321 ? 44.648 -5.595 -1.979 1.00 13.48 ? 321 TRP A NE1 1 ATOM 2475 C CE2 . TRP A 1 321 ? 43.681 -5.301 -1.043 1.00 12.76 ? 321 TRP A CE2 1 ATOM 2476 C CE3 . TRP A 1 321 ? 42.055 -3.560 -0.629 1.00 8.55 ? 321 TRP A CE3 1 ATOM 2477 C CZ2 . TRP A 1 321 ? 43.258 -6.016 0.088 1.00 14.00 ? 321 TRP A CZ2 1 ATOM 2478 C CZ3 . TRP A 1 321 ? 41.648 -4.256 0.483 1.00 11.47 ? 321 TRP A CZ3 1 ATOM 2479 C CH2 . TRP A 1 321 ? 42.195 -5.482 0.816 1.00 12.95 ? 321 TRP A CH2 1 ATOM 2480 N N . MET A 1 322 ? 44.605 -0.023 -5.070 1.00 8.62 ? 322 MET A N 1 ATOM 2481 C CA . MET A 1 322 ? 44.519 0.885 -6.199 1.00 8.60 ? 322 MET A CA 1 ATOM 2482 C C . MET A 1 322 ? 44.597 0.016 -7.423 1.00 8.56 ? 322 MET A C 1 ATOM 2483 O O . MET A 1 322 ? 45.491 -0.836 -7.537 1.00 7.45 ? 322 MET A O 1 ATOM 2484 C CB . MET A 1 322 ? 45.731 1.861 -6.194 1.00 8.24 ? 322 MET A CB 1 ATOM 2485 C CG . MET A 1 322 ? 45.795 2.819 -7.383 1.00 8.53 ? 322 MET A CG 1 ATOM 2486 S SD . MET A 1 322 ? 47.305 3.833 -7.356 1.00 15.22 ? 322 MET A SD 1 ATOM 2487 C CE . MET A 1 322 ? 46.862 4.994 -6.590 1.00 18.48 ? 322 MET A CE 1 ATOM 2488 N N . THR A 1 323 ? 43.690 0.246 -8.362 1.00 8.66 ? 323 THR A N 1 ATOM 2489 C CA . THR A 1 323 ? 43.701 -0.545 -9.583 1.00 8.41 ? 323 THR A CA 1 ATOM 2490 C C . THR A 1 323 ? 43.348 0.289 -10.785 1.00 9.30 ? 323 THR A C 1 ATOM 2491 O O . THR A 1 323 ? 42.507 1.197 -10.689 1.00 8.25 ? 323 THR A O 1 ATOM 2492 C CB . THR A 1 323 ? 42.705 -1.721 -9.492 1.00 8.12 ? 323 THR A CB 1 ATOM 2493 O OG1 . THR A 1 323 ? 42.707 -2.438 -10.742 1.00 9.71 ? 323 THR A OG1 1 ATOM 2494 C CG2 . THR A 1 323 ? 41.295 -1.214 -9.369 1.00 5.93 ? 323 THR A CG2 1 ATOM 2495 N N . ASP A 1 324 ? 44.025 -0.009 -11.901 1.00 9.77 ? 324 ASP A N 1 ATOM 2496 C CA . ASP A 1 324 ? 43.680 0.583 -13.180 1.00 11.04 ? 324 ASP A CA 1 ATOM 2497 C C . ASP A 1 324 ? 42.850 -0.413 -14.049 1.00 10.94 ? 324 ASP A C 1 ATOM 2498 O O . ASP A 1 324 ? 42.822 -0.299 -15.300 1.00 11.09 ? 324 ASP A O 1 ATOM 2499 C CB . ASP A 1 324 ? 44.943 0.981 -13.930 1.00 11.46 ? 324 ASP A CB 1 ATOM 2500 C CG . ASP A 1 324 ? 45.723 -0.209 -14.344 1.00 12.40 ? 324 ASP A CG 1 ATOM 2501 O OD1 . ASP A 1 324 ? 46.643 -0.049 -15.156 1.00 13.57 ? 324 ASP A OD1 1 ATOM 2502 O OD2 . ASP A 1 324 ? 45.452 -1.349 -13.908 1.00 10.34 ? 324 ASP A OD2 1 ATOM 2503 N N . ASN A 1 325 ? 42.169 -1.344 -13.390 1.00 9.50 ? 325 ASN A N 1 ATOM 2504 C CA . ASN A 1 325 ? 41.377 -2.377 -14.077 1.00 10.50 ? 325 ASN A CA 1 ATOM 2505 C C . ASN A 1 325 ? 42.254 -3.422 -14.766 1.00 10.63 ? 325 ASN A C 1 ATOM 2506 O O . ASN A 1 325 ? 41.734 -4.241 -15.550 1.00 10.95 ? 325 ASN A O 1 ATOM 2507 C CB . ASN A 1 325 ? 40.440 -1.771 -15.123 1.00 10.27 ? 325 ASN A CB 1 ATOM 2508 C CG . ASN A 1 325 ? 39.091 -2.481 -15.201 1.00 11.07 ? 325 ASN A CG 1 ATOM 2509 O OD1 . ASN A 1 325 ? 38.488 -2.509 -16.264 1.00 14.36 ? 325 ASN A OD1 1 ATOM 2510 N ND2 . ASN A 1 325 ? 38.610 -3.042 -14.090 1.00 6.42 ? 325 ASN A ND2 1 ATOM 2511 N N . GLN A 1 326 ? 43.570 -3.368 -14.520 1.00 9.40 ? 326 GLN A N 1 ATOM 2512 C CA . GLN A 1 326 ? 44.466 -4.401 -15.018 1.00 10.17 ? 326 GLN A CA 1 ATOM 2513 C C . GLN A 1 326 ? 45.348 -4.858 -13.847 1.00 10.61 ? 326 GLN A C 1 ATOM 2514 O O . GLN A 1 326 ? 45.246 -6.012 -13.364 1.00 10.93 ? 326 GLN A O 1 ATOM 2515 C CB . GLN A 1 326 ? 45.295 -3.872 -16.216 1.00 10.79 ? 326 GLN A CB 1 ATOM 2516 C CG . GLN A 1 326 ? 44.435 -3.144 -17.342 1.00 12.63 ? 326 GLN A CG 1 ATOM 2517 C CD . GLN A 1 326 ? 45.289 -2.492 -18.491 1.00 16.49 ? 326 GLN A CD 1 ATOM 2518 O OE1 . GLN A 1 326 ? 44.843 -2.395 -19.629 1.00 18.88 ? 326 GLN A OE1 1 ATOM 2519 N NE2 . GLN A 1 326 ? 46.505 -2.072 -18.169 1.00 20.43 ? 326 GLN A NE2 1 ATOM 2520 N N . ARG A 1 327 ? 46.198 -3.951 -13.373 1.00 10.01 ? 327 ARG A N 1 ATOM 2521 C CA . ARG A 1 327 ? 47.040 -4.227 -12.229 1.00 9.13 ? 327 ARG A CA 1 ATOM 2522 C C . ARG A 1 327 ? 46.249 -3.903 -10.980 1.00 9.20 ? 327 ARG A C 1 ATOM 2523 O O . ARG A 1 327 ? 45.337 -3.056 -10.997 1.00 8.75 ? 327 ARG A O 1 ATOM 2524 C CB . ARG A 1 327 ? 48.321 -3.392 -12.264 1.00 9.42 ? 327 ARG A CB 1 ATOM 2525 C CG . ARG A 1 327 ? 49.088 -3.507 -13.566 1.00 9.74 ? 327 ARG A CG 1 ATOM 2526 C CD . ARG A 1 327 ? 48.800 -2.390 -14.544 1.00 11.82 ? 327 ARG A CD 1 ATOM 2527 N NE . ARG A 1 327 ? 49.346 -2.688 -15.847 1.00 17.22 ? 327 ARG A NE 1 ATOM 2528 C CZ . ARG A 1 327 ? 49.601 -1.770 -16.762 1.00 16.42 ? 327 ARG A CZ 1 ATOM 2529 N NH1 . ARG A 1 327 ? 49.344 -0.497 -16.493 1.00 11.90 ? 327 ARG A NH1 1 ATOM 2530 N NH2 . ARG A 1 327 ? 50.119 -2.136 -17.929 1.00 15.60 ? 327 ARG A NH2 1 ATOM 2531 N N . ILE A 1 328 ? 46.571 -4.602 -9.899 1.00 9.07 ? 328 ILE A N 1 ATOM 2532 C CA . ILE A 1 328 ? 45.925 -4.369 -8.631 1.00 9.21 ? 328 ILE A CA 1 ATOM 2533 C C . ILE A 1 328 ? 46.970 -4.265 -7.535 1.00 10.42 ? 328 ILE A C 1 ATOM 2534 O O . ILE A 1 328 ? 47.552 -5.270 -7.155 1.00 10.64 ? 328 ILE A O 1 ATOM 2535 C CB . ILE A 1 328 ? 44.944 -5.508 -8.298 1.00 9.00 ? 328 ILE A CB 1 ATOM 2536 C CG1 . ILE A 1 328 ? 43.852 -5.588 -9.371 1.00 8.33 ? 328 ILE A CG1 1 ATOM 2537 C CG2 . ILE A 1 328 ? 44.323 -5.248 -6.916 1.00 7.15 ? 328 ILE A CG2 1 ATOM 2538 C CD1 . ILE A 1 328 ? 42.837 -6.752 -9.199 1.00 13.27 ? 328 ILE A CD1 1 ATOM 2539 N N . PHE A 1 329 ? 47.181 -3.045 -7.026 1.00 10.54 ? 329 PHE A N 1 ATOM 2540 C CA . PHE A 1 329 ? 48.193 -2.756 -6.007 1.00 9.72 ? 329 PHE A CA 1 ATOM 2541 C C . PHE A 1 329 ? 47.620 -2.598 -4.607 1.00 9.54 ? 329 PHE A C 1 ATOM 2542 O O . PHE A 1 329 ? 46.667 -1.873 -4.405 1.00 10.12 ? 329 PHE A O 1 ATOM 2543 C CB . PHE A 1 329 ? 48.929 -1.472 -6.361 1.00 8.48 ? 329 PHE A CB 1 ATOM 2544 C CG . PHE A 1 329 ? 50.110 -1.186 -5.468 1.00 10.97 ? 329 PHE A CG 1 ATOM 2545 C CD1 . PHE A 1 329 ? 51.302 -1.858 -5.642 1.00 8.19 ? 329 PHE A CD1 1 ATOM 2546 C CD2 . PHE A 1 329 ? 50.030 -0.226 -4.453 1.00 11.06 ? 329 PHE A CD2 1 ATOM 2547 C CE1 . PHE A 1 329 ? 52.424 -1.590 -4.795 1.00 9.39 ? 329 PHE A CE1 1 ATOM 2548 C CE2 . PHE A 1 329 ? 51.125 0.063 -3.635 1.00 12.37 ? 329 PHE A CE2 1 ATOM 2549 C CZ . PHE A 1 329 ? 52.337 -0.637 -3.804 1.00 12.23 ? 329 PHE A CZ 1 ATOM 2550 N N . ASP A 1 330 ? 48.225 -3.261 -3.640 1.00 9.96 ? 330 ASP A N 1 ATOM 2551 C CA . ASP A 1 330 ? 47.792 -3.150 -2.238 1.00 10.38 ? 330 ASP A CA 1 ATOM 2552 C C . ASP A 1 330 ? 48.607 -1.995 -1.623 1.00 9.99 ? 330 ASP A C 1 ATOM 2553 O O . ASP A 1 330 ? 49.789 -2.130 -1.312 1.00 9.43 ? 330 ASP A O 1 ATOM 2554 C CB . ASP A 1 330 ? 48.064 -4.474 -1.527 1.00 9.46 ? 330 ASP A CB 1 ATOM 2555 C CG . ASP A 1 330 ? 47.688 -4.446 -0.080 1.00 12.06 ? 330 ASP A CG 1 ATOM 2556 O OD1 . ASP A 1 330 ? 47.133 -3.435 0.378 1.00 11.63 ? 330 ASP A OD1 1 ATOM 2557 O OD2 . ASP A 1 330 ? 47.941 -5.398 0.696 1.00 15.13 ? 330 ASP A OD2 1 ATOM 2558 N N . VAL A 1 331 ? 47.986 -0.841 -1.477 1.00 10.17 ? 331 VAL A N 1 ATOM 2559 C CA . VAL A 1 331 ? 48.734 0.313 -1.019 1.00 9.73 ? 331 VAL A CA 1 ATOM 2560 C C . VAL A 1 331 ? 49.218 0.048 0.393 1.00 10.31 ? 331 VAL A C 1 ATOM 2561 O O . VAL A 1 331 ? 50.229 0.548 0.828 1.00 9.71 ? 331 VAL A O 1 ATOM 2562 C CB . VAL A 1 331 ? 47.846 1.561 -1.015 1.00 10.37 ? 331 VAL A CB 1 ATOM 2563 C CG1 . VAL A 1 331 ? 48.621 2.779 -0.478 1.00 7.81 ? 331 VAL A CG1 1 ATOM 2564 C CG2 . VAL A 1 331 ? 47.291 1.836 -2.428 1.00 8.14 ? 331 VAL A CG2 1 ATOM 2565 N N . GLY A 1 332 ? 48.391 -0.686 1.131 1.00 10.29 ? 332 GLY A N 1 ATOM 2566 C CA . GLY A 1 332 ? 48.739 -1.048 2.484 1.00 10.25 ? 332 GLY A CA 1 ATOM 2567 C C . GLY A 1 332 ? 47.599 -0.973 3.488 1.00 10.98 ? 332 GLY A C 1 ATOM 2568 O O . GLY A 1 332 ? 46.432 -0.797 3.120 1.00 10.05 ? 332 GLY A O 1 ATOM 2569 N N . GLN A 1 333 ? 47.951 -1.087 4.770 1.00 10.93 ? 333 GLN A N 1 ATOM 2570 C CA . GLN A 1 333 ? 46.970 -1.046 5.862 1.00 11.00 ? 333 GLN A CA 1 ATOM 2571 C C . GLN A 1 333 ? 46.772 0.390 6.352 1.00 10.44 ? 333 GLN A C 1 ATOM 2572 O O . GLN A 1 333 ? 47.702 0.997 6.804 1.00 10.45 ? 333 GLN A O 1 ATOM 2573 C CB . GLN A 1 333 ? 47.427 -1.905 7.064 1.00 11.10 ? 333 GLN A CB 1 ATOM 2574 C CG . GLN A 1 333 ? 46.312 -1.995 8.216 1.00 13.07 ? 333 GLN A CG 1 ATOM 2575 C CD . GLN A 1 333 ? 46.737 -2.901 9.413 1.00 12.43 ? 333 GLN A CD 1 ATOM 2576 O OE1 . GLN A 1 333 ? 47.027 -4.072 9.221 1.00 10.46 ? 333 GLN A OE1 1 ATOM 2577 N NE2 . GLN A 1 333 ? 46.812 -2.324 10.619 1.00 10.22 ? 333 GLN A NE2 1 ATOM 2578 N N . ILE A 1 334 ? 45.571 0.928 6.274 1.00 10.33 ? 334 ILE A N 1 ATOM 2579 C CA . ILE A 1 334 ? 45.375 2.260 6.795 1.00 10.92 ? 334 ILE A CA 1 ATOM 2580 C C . ILE A 1 334 ? 44.904 2.301 8.249 1.00 11.78 ? 334 ILE A C 1 ATOM 2581 O O . ILE A 1 334 ? 45.074 3.313 8.901 1.00 12.26 ? 334 ILE A O 1 ATOM 2582 C CB . ILE A 1 334 ? 44.495 3.091 5.905 1.00 11.25 ? 334 ILE A CB 1 ATOM 2583 C CG1 . ILE A 1 334 ? 43.047 2.689 6.010 1.00 12.99 ? 334 ILE A CG1 1 ATOM 2584 C CG2 . ILE A 1 334 ? 44.949 3.011 4.409 1.00 12.52 ? 334 ILE A CG2 1 ATOM 2585 C CD1 . ILE A 1 334 ? 42.244 3.200 4.783 1.00 15.99 ? 334 ILE A CD1 1 ATOM 2586 N N . SER A 1 335 ? 44.305 1.226 8.768 1.00 11.45 ? 335 SER A N 1 ATOM 2587 C CA . SER A 1 335 ? 43.972 1.234 10.207 1.00 12.12 ? 335 SER A CA 1 ATOM 2588 C C . SER A 1 335 ? 45.264 0.982 10.992 1.00 12.04 ? 335 SER A C 1 ATOM 2589 O O . SER A 1 335 ? 46.328 0.784 10.402 1.00 12.20 ? 335 SER A O 1 ATOM 2590 C CB . SER A 1 335 ? 42.887 0.216 10.564 1.00 11.06 ? 335 SER A CB 1 ATOM 2591 O OG . SER A 1 335 ? 43.244 -1.086 10.114 1.00 11.94 ? 335 SER A OG 1 ATOM 2592 N N . ILE A 1 336 ? 45.189 0.999 12.312 1.00 12.29 ? 336 ILE A N 1 ATOM 2593 C CA . ILE A 1 336 ? 46.406 0.852 13.110 1.00 12.26 ? 336 ILE A CA 1 ATOM 2594 C C . ILE A 1 336 ? 46.493 -0.486 13.862 1.00 13.24 ? 336 ILE A C 1 ATOM 2595 O O . ILE A 1 336 ? 45.616 -0.846 14.651 1.00 12.96 ? 336 ILE A O 1 ATOM 2596 C CB . ILE A 1 336 ? 46.576 2.067 14.097 1.00 12.89 ? 336 ILE A CB 1 ATOM 2597 C CG1 . ILE A 1 336 ? 46.740 3.369 13.315 1.00 10.68 ? 336 ILE A CG1 1 ATOM 2598 C CG2 . ILE A 1 336 ? 47.782 1.837 15.066 1.00 12.22 ? 336 ILE A CG2 1 ATOM 2599 C CD1 . ILE A 1 336 ? 46.849 4.661 14.197 1.00 15.58 ? 336 ILE A CD1 1 ATOM 2600 N N . GLY A 1 337 ? 47.559 -1.225 13.593 1.00 14.08 ? 337 GLY A N 1 ATOM 2601 C CA . GLY A 1 337 ? 47.808 -2.484 14.267 1.00 14.55 ? 337 GLY A CA 1 ATOM 2602 C C . GLY A 1 337 ? 46.658 -3.462 14.073 1.00 15.51 ? 337 GLY A C 1 ATOM 2603 O O . GLY A 1 337 ? 46.115 -3.639 12.945 1.00 15.02 ? 337 GLY A O 1 ATOM 2604 N N . ASP A 1 338 ? 46.273 -4.112 15.166 1.00 15.29 ? 338 ASP A N 1 ATOM 2605 C CA . ASP A 1 338 ? 45.191 -5.074 15.059 1.00 16.04 ? 338 ASP A CA 1 ATOM 2606 C C . ASP A 1 338 ? 43.877 -4.481 15.539 1.00 15.37 ? 338 ASP A C 1 ATOM 2607 O O . ASP A 1 338 ? 42.956 -5.214 15.903 1.00 14.59 ? 338 ASP A O 1 ATOM 2608 C CB . ASP A 1 338 ? 45.527 -6.392 15.780 1.00 16.53 ? 338 ASP A CB 1 ATOM 2609 C CG . ASP A 1 338 ? 45.380 -6.309 17.280 1.00 19.41 ? 338 ASP A CG 1 ATOM 2610 O OD1 . ASP A 1 338 ? 45.551 -5.226 17.859 1.00 19.76 ? 338 ASP A OD1 1 ATOM 2611 O OD2 . ASP A 1 338 ? 45.063 -7.304 17.981 1.00 28.24 ? 338 ASP A OD2 1 ATOM 2612 N N . GLU A 1 339 ? 43.772 -3.161 15.565 1.00 13.57 ? 339 GLU A N 1 ATOM 2613 C CA . GLU A 1 339 ? 42.489 -2.622 16.003 1.00 13.44 ? 339 GLU A CA 1 ATOM 2614 C C . GLU A 1 339 ? 41.321 -3.067 15.062 1.00 12.97 ? 339 GLU A C 1 ATOM 2615 O O . GLU A 1 339 ? 41.527 -3.331 13.863 1.00 11.92 ? 339 GLU A O 1 ATOM 2616 C CB . GLU A 1 339 ? 42.542 -1.087 16.010 1.00 13.16 ? 339 GLU A CB 1 ATOM 2617 C CG . GLU A 1 339 ? 42.389 -0.441 14.612 1.00 14.44 ? 339 GLU A CG 1 ATOM 2618 C CD . GLU A 1 339 ? 42.655 1.072 14.612 1.00 15.18 ? 339 GLU A CD 1 ATOM 2619 O OE1 . GLU A 1 339 ? 42.980 1.614 13.542 1.00 14.03 ? 339 GLU A OE1 1 ATOM 2620 O OE2 . GLU A 1 339 ? 42.548 1.728 15.696 1.00 14.04 ? 339 GLU A OE2 1 ATOM 2621 N N . ASN A 1 340 ? 40.106 -3.125 15.604 1.00 12.80 ? 340 ASN A N 1 ATOM 2622 C CA . ASN A 1 340 ? 38.914 -3.361 14.804 1.00 12.40 ? 340 ASN A CA 1 ATOM 2623 C C . ASN A 1 340 ? 38.494 -2.088 14.096 1.00 12.49 ? 340 ASN A C 1 ATOM 2624 O O . ASN A 1 340 ? 38.376 -1.040 14.729 1.00 11.53 ? 340 ASN A O 1 ATOM 2625 C CB . ASN A 1 340 ? 37.798 -3.857 15.683 1.00 13.30 ? 340 ASN A CB 1 ATOM 2626 C CG . ASN A 1 340 ? 38.187 -5.121 16.444 1.00 16.03 ? 340 ASN A CG 1 ATOM 2627 O OD1 . ASN A 1 340 ? 38.888 -5.991 15.912 1.00 16.92 ? 340 ASN A OD1 1 ATOM 2628 N ND2 . ASN A 1 340 ? 37.745 -5.224 17.687 1.00 17.12 ? 340 ASN A ND2 1 ATOM 2629 N N . SER A 1 341 ? 38.297 -2.155 12.772 1.00 12.11 ? 341 SER A N 1 ATOM 2630 C CA . SER A 1 341 ? 37.825 -0.981 12.042 1.00 12.40 ? 341 SER A CA 1 ATOM 2631 C C . SER A 1 341 ? 36.386 -1.209 11.639 1.00 12.98 ? 341 SER A C 1 ATOM 2632 O O . SER A 1 341 ? 35.540 -1.409 12.516 1.00 13.07 ? 341 SER A O 1 ATOM 2633 C CB . SER A 1 341 ? 38.701 -0.672 10.828 1.00 12.76 ? 341 SER A CB 1 ATOM 2634 O OG . SER A 1 341 ? 38.741 -1.724 9.898 1.00 12.52 ? 341 SER A OG 1 ATOM 2635 N N . GLY A 1 342 ? 36.098 -1.227 10.330 1.00 12.38 ? 342 GLY A N 1 ATOM 2636 C CA . GLY A 1 342 ? 34.735 -1.415 9.844 1.00 11.57 ? 342 GLY A CA 1 ATOM 2637 C C . GLY A 1 342 ? 34.472 -0.648 8.556 1.00 12.19 ? 342 GLY A C 1 ATOM 2638 O O . GLY A 1 342 ? 35.270 -0.737 7.603 1.00 12.13 ? 342 GLY A O 1 ATOM 2639 N N . TYR A 1 343 ? 33.391 0.128 8.528 1.00 11.80 ? 343 TYR A N 1 ATOM 2640 C CA . TYR A 1 343 ? 32.987 0.867 7.337 1.00 12.12 ? 343 TYR A CA 1 ATOM 2641 C C . TYR A 1 343 ? 33.990 1.977 7.079 1.00 12.59 ? 343 TYR A C 1 ATOM 2642 O O . TYR A 1 343 ? 34.579 2.481 8.031 1.00 12.88 ? 343 TYR A O 1 ATOM 2643 C CB . TYR A 1 343 ? 31.594 1.492 7.518 1.00 12.83 ? 343 TYR A CB 1 ATOM 2644 C CG . TYR A 1 343 ? 30.414 0.527 7.373 1.00 13.90 ? 343 TYR A CG 1 ATOM 2645 C CD1 . TYR A 1 343 ? 30.377 -0.670 8.079 1.00 19.12 ? 343 TYR A CD1 1 ATOM 2646 C CD2 . TYR A 1 343 ? 29.347 0.809 6.545 1.00 13.09 ? 343 TYR A CD2 1 ATOM 2647 C CE1 . TYR A 1 343 ? 29.281 -1.583 7.940 1.00 17.73 ? 343 TYR A CE1 1 ATOM 2648 C CE2 . TYR A 1 343 ? 28.247 -0.087 6.412 1.00 12.11 ? 343 TYR A CE2 1 ATOM 2649 C CZ . TYR A 1 343 ? 28.232 -1.264 7.113 1.00 14.12 ? 343 TYR A CZ 1 ATOM 2650 O OH . TYR A 1 343 ? 27.184 -2.132 7.023 1.00 15.38 ? 343 TYR A OH 1 ATOM 2651 N N . SER A 1 344 ? 34.168 2.383 5.814 1.00 11.32 ? 344 SER A N 1 ATOM 2652 C CA . SER A 1 344 ? 35.179 3.372 5.486 1.00 10.56 ? 344 SER A CA 1 ATOM 2653 C C . SER A 1 344 ? 34.803 4.235 4.284 1.00 10.83 ? 344 SER A C 1 ATOM 2654 O O . SER A 1 344 ? 33.870 3.930 3.542 1.00 10.12 ? 344 SER A O 1 ATOM 2655 C CB . SER A 1 344 ? 36.474 2.660 5.146 1.00 11.05 ? 344 SER A CB 1 ATOM 2656 O OG . SER A 1 344 ? 36.259 1.746 4.074 1.00 10.97 ? 344 SER A OG 1 ATOM 2657 N N . SER A 1 345 ? 35.618 5.259 4.052 1.00 11.49 ? 345 SER A N 1 ATOM 2658 C CA . SER A 1 345 ? 35.460 6.205 2.970 1.00 11.51 ? 345 SER A CA 1 ATOM 2659 C C . SER A 1 345 ? 36.866 6.808 2.651 1.00 11.71 ? 345 SER A C 1 ATOM 2660 O O . SER A 1 345 ? 37.675 6.995 3.562 1.00 11.70 ? 345 SER A O 1 ATOM 2661 C CB . SER A 1 345 ? 34.454 7.279 3.477 1.00 11.83 ? 345 SER A CB 1 ATOM 2662 O OG . SER A 1 345 ? 34.315 8.427 2.650 1.00 12.43 ? 345 SER A OG 1 ATOM 2663 N N . VAL A 1 346 ? 37.162 7.051 1.372 1.00 11.86 ? 346 VAL A N 1 ATOM 2664 C CA . VAL A 1 346 ? 38.414 7.683 0.957 1.00 12.51 ? 346 VAL A CA 1 ATOM 2665 C C . VAL A 1 346 ? 38.140 8.880 0.045 1.00 12.55 ? 346 VAL A C 1 ATOM 2666 O O . VAL A 1 346 ? 37.099 8.908 -0.675 1.00 13.15 ? 346 VAL A O 1 ATOM 2667 C CB . VAL A 1 346 ? 39.393 6.683 0.284 1.00 13.62 ? 346 VAL A CB 1 ATOM 2668 C CG1 . VAL A 1 346 ? 39.758 5.601 1.263 1.00 15.65 ? 346 VAL A CG1 1 ATOM 2669 C CG2 . VAL A 1 346 ? 38.730 6.066 -0.957 1.00 11.38 ? 346 VAL A CG2 1 ATOM 2670 N N . LEU A 1 347 ? 38.988 9.897 0.097 1.00 11.72 ? 347 LEU A N 1 ATOM 2671 C CA . LEU A 1 347 ? 38.682 11.099 -0.655 1.00 12.04 ? 347 LEU A CA 1 ATOM 2672 C C . LEU A 1 347 ? 39.971 11.745 -1.106 1.00 11.96 ? 347 LEU A C 1 ATOM 2673 O O . LEU A 1 347 ? 40.886 11.906 -0.317 1.00 11.40 ? 347 LEU A O 1 ATOM 2674 C CB . LEU A 1 347 ? 37.858 12.077 0.211 1.00 12.57 ? 347 LEU A CB 1 ATOM 2675 C CG . LEU A 1 347 ? 37.991 13.556 -0.196 1.00 13.45 ? 347 LEU A CG 1 ATOM 2676 C CD1 . LEU A 1 347 ? 37.133 13.818 -1.442 1.00 13.75 ? 347 LEU A CD1 1 ATOM 2677 C CD2 . LEU A 1 347 ? 37.635 14.500 0.941 1.00 10.53 ? 347 LEU A CD2 1 ATOM 2678 N N . TYR A 1 348 ? 40.050 12.068 -2.391 1.00 11.84 ? 348 TYR A N 1 ATOM 2679 C CA . TYR A 1 348 ? 41.222 12.702 -2.934 1.00 12.18 ? 348 TYR A CA 1 ATOM 2680 C C . TYR A 1 348 ? 40.797 14.110 -3.281 1.00 12.95 ? 348 TYR A C 1 ATOM 2681 O O . TYR A 1 348 ? 39.916 14.326 -4.131 1.00 11.83 ? 348 TYR A O 1 ATOM 2682 C CB . TYR A 1 348 ? 41.687 11.959 -4.168 1.00 12.30 ? 348 TYR A CB 1 ATOM 2683 C CG . TYR A 1 348 ? 42.993 12.433 -4.758 1.00 13.68 ? 348 TYR A CG 1 ATOM 2684 C CD1 . TYR A 1 348 ? 44.162 12.468 -3.995 1.00 14.77 ? 348 TYR A CD1 1 ATOM 2685 C CD2 . TYR A 1 348 ? 43.068 12.799 -6.086 1.00 16.73 ? 348 TYR A CD2 1 ATOM 2686 C CE1 . TYR A 1 348 ? 45.345 12.884 -4.525 1.00 16.62 ? 348 TYR A CE1 1 ATOM 2687 C CE2 . TYR A 1 348 ? 44.286 13.224 -6.646 1.00 18.45 ? 348 TYR A CE2 1 ATOM 2688 C CZ . TYR A 1 348 ? 45.409 13.255 -5.858 1.00 18.88 ? 348 TYR A CZ 1 ATOM 2689 O OH . TYR A 1 348 ? 46.601 13.644 -6.416 1.00 20.43 ? 348 TYR A OH 1 ATOM 2690 N N . LYS A 1 349 ? 41.403 15.077 -2.613 1.00 13.84 ? 349 LYS A N 1 ATOM 2691 C CA . LYS A 1 349 ? 41.010 16.478 -2.822 1.00 15.64 ? 349 LYS A CA 1 ATOM 2692 C C . LYS A 1 349 ? 42.228 17.382 -2.797 1.00 15.96 ? 349 LYS A C 1 ATOM 2693 O O . LYS A 1 349 ? 43.076 17.276 -1.919 1.00 15.78 ? 349 LYS A O 1 ATOM 2694 C CB . LYS A 1 349 ? 39.959 16.910 -1.758 1.00 16.28 ? 349 LYS A CB 1 ATOM 2695 C CG . LYS A 1 349 ? 39.790 18.445 -1.528 1.00 14.94 ? 349 LYS A CG 1 ATOM 2696 C CD . LYS A 1 349 ? 38.845 18.677 -0.348 1.00 15.79 ? 349 LYS A CD 1 ATOM 2697 C CE . LYS A 1 349 ? 38.612 20.173 -0.036 1.00 14.70 ? 349 LYS A CE 1 ATOM 2698 N NZ . LYS A 1 349 ? 39.811 21.067 -0.270 1.00 12.46 ? 349 LYS A NZ 1 ATOM 2699 N N . ASP A 1 350 ? 42.338 18.228 -3.809 1.00 17.60 ? 350 ASP A N 1 ATOM 2700 C CA . ASP A 1 350 ? 43.440 19.153 -3.906 1.00 18.64 ? 350 ASP A CA 1 ATOM 2701 C C . ASP A 1 350 ? 44.735 18.394 -3.685 1.00 18.97 ? 350 ASP A C 1 ATOM 2702 O O . ASP A 1 350 ? 45.603 18.811 -2.916 1.00 19.31 ? 350 ASP A O 1 ATOM 2703 C CB . ASP A 1 350 ? 43.265 20.295 -2.891 1.00 19.95 ? 350 ASP A CB 1 ATOM 2704 C CG . ASP A 1 350 ? 41.905 20.976 -3.012 1.00 21.80 ? 350 ASP A CG 1 ATOM 2705 O OD1 . ASP A 1 350 ? 41.427 21.111 -4.149 1.00 27.51 ? 350 ASP A OD1 1 ATOM 2706 O OD2 . ASP A 1 350 ? 41.213 21.384 -2.050 1.00 25.19 ? 350 ASP A OD2 1 ATOM 2707 N N . ASP A 1 351 ? 44.848 17.258 -4.366 1.00 18.99 ? 351 ASP A N 1 ATOM 2708 C CA . ASP A 1 351 ? 46.062 16.480 -4.367 1.00 18.19 ? 351 ASP A CA 1 ATOM 2709 C C . ASP A 1 351 ? 46.498 16.075 -2.961 1.00 17.59 ? 351 ASP A C 1 ATOM 2710 O O . ASP A 1 351 ? 47.693 15.960 -2.650 1.00 16.93 ? 351 ASP A O 1 ATOM 2711 C CB . ASP A 1 351 ? 47.144 17.260 -5.098 1.00 19.58 ? 351 ASP A CB 1 ATOM 2712 C CG . ASP A 1 351 ? 48.449 16.481 -5.215 1.00 21.51 ? 351 ASP A CG 1 ATOM 2713 O OD1 . ASP A 1 351 ? 49.489 17.050 -4.824 1.00 22.85 ? 351 ASP A OD1 1 ATOM 2714 O OD2 . ASP A 1 351 ? 48.521 15.309 -5.652 1.00 20.02 ? 351 ASP A OD2 1 ATOM 2715 N N . LYS A 1 352 ? 45.509 15.857 -2.108 1.00 16.57 ? 352 LYS A N 1 ATOM 2716 C CA . LYS A 1 352 ? 45.777 15.294 -0.811 1.00 16.58 ? 352 LYS A CA 1 ATOM 2717 C C . LYS A 1 352 ? 44.794 14.141 -0.570 1.00 15.60 ? 352 LYS A C 1 ATOM 2718 O O . LYS A 1 352 ? 43.630 14.199 -0.988 1.00 15.02 ? 352 LYS A O 1 ATOM 2719 C CB . LYS A 1 352 ? 45.783 16.382 0.267 1.00 18.27 ? 352 LYS A CB 1 ATOM 2720 C CG . LYS A 1 352 ? 47.184 17.075 0.326 1.00 20.13 ? 352 LYS A CG 1 ATOM 2721 C CD . LYS A 1 352 ? 47.196 18.387 1.093 1.00 26.77 ? 352 LYS A CD 1 ATOM 2722 C CE . LYS A 1 352 ? 48.500 19.166 0.781 1.00 31.49 ? 352 LYS A CE 1 ATOM 2723 N NZ . LYS A 1 352 ? 48.258 20.059 -0.393 1.00 32.77 ? 352 LYS A NZ 1 ATOM 2724 N N . LEU A 1 353 ? 45.274 13.060 0.038 1.00 13.54 ? 353 LEU A N 1 ATOM 2725 C CA . LEU A 1 353 ? 44.433 11.876 0.227 1.00 12.95 ? 353 LEU A CA 1 ATOM 2726 C C . LEU A 1 353 ? 44.011 11.664 1.695 1.00 12.66 ? 353 LEU A C 1 ATOM 2727 O O . LEU A 1 353 ? 44.830 11.757 2.594 1.00 13.03 ? 353 LEU A O 1 ATOM 2728 C CB . LEU A 1 353 ? 45.200 10.655 -0.279 1.00 12.33 ? 353 LEU A CB 1 ATOM 2729 C CG . LEU A 1 353 ? 44.504 9.301 -0.290 1.00 13.95 ? 353 LEU A CG 1 ATOM 2730 C CD1 . LEU A 1 353 ? 43.288 9.356 -1.220 1.00 13.14 ? 353 LEU A CD1 1 ATOM 2731 C CD2 . LEU A 1 353 ? 45.496 8.224 -0.706 1.00 11.23 ? 353 LEU A CD2 1 ATOM 2732 N N . TYR A 1 354 ? 42.758 11.308 1.927 1.00 12.55 ? 354 TYR A N 1 ATOM 2733 C CA . TYR A 1 354 ? 42.229 11.132 3.286 1.00 12.48 ? 354 TYR A CA 1 ATOM 2734 C C . TYR A 1 354 ? 41.325 9.918 3.411 1.00 12.81 ? 354 TYR A C 1 ATOM 2735 O O . TYR A 1 354 ? 40.724 9.451 2.426 1.00 12.26 ? 354 TYR A O 1 ATOM 2736 C CB . TYR A 1 354 ? 41.306 12.328 3.643 1.00 13.24 ? 354 TYR A CB 1 ATOM 2737 C CG . TYR A 1 354 ? 41.895 13.719 3.371 1.00 13.57 ? 354 TYR A CG 1 ATOM 2738 C CD1 . TYR A 1 354 ? 41.790 14.308 2.123 1.00 14.38 ? 354 TYR A CD1 1 ATOM 2739 C CD2 . TYR A 1 354 ? 42.541 14.423 4.383 1.00 14.68 ? 354 TYR A CD2 1 ATOM 2740 C CE1 . TYR A 1 354 ? 42.348 15.569 1.876 1.00 18.03 ? 354 TYR A CE1 1 ATOM 2741 C CE2 . TYR A 1 354 ? 43.095 15.672 4.170 1.00 17.26 ? 354 TYR A CE2 1 ATOM 2742 C CZ . TYR A 1 354 ? 42.996 16.243 2.915 1.00 19.27 ? 354 TYR A CZ 1 ATOM 2743 O OH . TYR A 1 354 ? 43.535 17.486 2.715 1.00 19.51 ? 354 TYR A OH 1 ATOM 2744 N N . SER A 1 355 ? 41.114 9.483 4.648 1.00 12.24 ? 355 SER A N 1 ATOM 2745 C CA . SER A 1 355 ? 40.080 8.503 4.901 1.00 11.95 ? 355 SER A CA 1 ATOM 2746 C C . SER A 1 355 ? 39.233 8.906 6.115 1.00 11.85 ? 355 SER A C 1 ATOM 2747 O O . SER A 1 355 ? 39.751 9.586 6.992 1.00 12.14 ? 355 SER A O 1 ATOM 2748 C CB . SER A 1 355 ? 40.699 7.151 5.157 1.00 12.09 ? 355 SER A CB 1 ATOM 2749 O OG . SER A 1 355 ? 39.684 6.282 5.588 1.00 12.14 ? 355 SER A OG 1 ATOM 2750 N N . LEU A 1 356 ? 37.932 8.579 6.106 1.00 10.25 ? 356 LEU A N 1 ATOM 2751 C CA . LEU A 1 356 ? 37.110 8.650 7.293 1.00 10.84 ? 356 LEU A CA 1 ATOM 2752 C C . LEU A 1 356 ? 36.672 7.202 7.518 1.00 10.37 ? 356 LEU A C 1 ATOM 2753 O O . LEU A 1 356 ? 35.969 6.606 6.675 1.00 10.43 ? 356 LEU A O 1 ATOM 2754 C CB . LEU A 1 356 ? 35.805 9.430 7.077 1.00 10.40 ? 356 LEU A CB 1 ATOM 2755 C CG . LEU A 1 356 ? 35.180 10.399 8.091 1.00 12.31 ? 356 LEU A CG 1 ATOM 2756 C CD1 . LEU A 1 356 ? 33.610 10.467 8.101 1.00 13.07 ? 356 LEU A CD1 1 ATOM 2757 C CD2 . LEU A 1 356 ? 35.740 10.487 9.496 1.00 11.52 ? 356 LEU A CD2 1 ATOM 2758 N N . HIS A 1 357 ? 37.006 6.632 8.653 1.00 9.59 ? 357 HIS A N 1 ATOM 2759 C CA . HIS A 1 357 ? 36.589 5.253 8.858 1.00 8.26 ? 357 HIS A CA 1 ATOM 2760 C C . HIS A 1 357 ? 36.316 4.868 10.301 1.00 9.44 ? 357 HIS A C 1 ATOM 2761 O O . HIS A 1 357 ? 36.801 5.505 11.252 1.00 9.28 ? 357 HIS A O 1 ATOM 2762 C CB . HIS A 1 357 ? 37.609 4.337 8.218 1.00 6.24 ? 357 HIS A CB 1 ATOM 2763 C CG . HIS A 1 357 ? 38.842 4.143 9.036 1.00 7.05 ? 357 HIS A CG 1 ATOM 2764 N ND1 . HIS A 1 357 ? 38.859 3.339 10.154 1.00 5.49 ? 357 HIS A ND1 1 ATOM 2765 C CD2 . HIS A 1 357 ? 40.116 4.587 8.859 1.00 2.52 ? 357 HIS A CD2 1 ATOM 2766 C CE1 . HIS A 1 357 ? 40.085 3.332 10.662 1.00 8.44 ? 357 HIS A CE1 1 ATOM 2767 N NE2 . HIS A 1 357 ? 40.871 4.061 9.884 1.00 7.77 ? 357 HIS A NE2 1 ATOM 2768 N N . GLU A 1 358 ? 35.555 3.800 10.489 1.00 9.92 ? 358 GLU A N 1 ATOM 2769 C CA . GLU A 1 358 ? 35.290 3.364 11.842 1.00 11.11 ? 358 GLU A CA 1 ATOM 2770 C C . GLU A 1 358 ? 36.480 2.784 12.602 1.00 12.08 ? 358 GLU A C 1 ATOM 2771 O O . GLU A 1 358 ? 37.388 2.161 11.996 1.00 12.53 ? 358 GLU A O 1 ATOM 2772 C CB . GLU A 1 358 ? 34.190 2.300 11.820 1.00 11.78 ? 358 GLU A CB 1 ATOM 2773 C CG . GLU A 1 358 ? 32.885 2.792 11.195 1.00 11.16 ? 358 GLU A CG 1 ATOM 2774 C CD . GLU A 1 358 ? 31.831 1.712 11.140 1.00 13.31 ? 358 GLU A CD 1 ATOM 2775 O OE1 . GLU A 1 358 ? 30.643 2.038 11.278 1.00 14.34 ? 358 GLU A OE1 1 ATOM 2776 O OE2 . GLU A 1 358 ? 32.190 0.547 10.943 1.00 11.37 ? 358 GLU A OE2 1 ATOM 2777 N N . ILE A 1 359 ? 36.463 3.001 13.918 1.00 11.46 ? 359 ILE A N 1 ATOM 2778 C CA . ILE A 1 359 ? 37.255 2.195 14.840 1.00 12.85 ? 359 ILE A CA 1 ATOM 2779 C C . ILE A 1 359 ? 36.325 1.709 15.934 1.00 13.05 ? 359 ILE A C 1 ATOM 2780 O O . ILE A 1 359 ? 35.393 2.409 16.359 1.00 13.09 ? 359 ILE A O 1 ATOM 2781 C CB . ILE A 1 359 ? 38.512 2.877 15.415 1.00 13.37 ? 359 ILE A CB 1 ATOM 2782 C CG1 . ILE A 1 359 ? 38.144 4.059 16.311 1.00 13.29 ? 359 ILE A CG1 1 ATOM 2783 C CG2 . ILE A 1 359 ? 39.500 3.243 14.283 1.00 12.71 ? 359 ILE A CG2 1 ATOM 2784 C CD1 . ILE A 1 359 ? 39.336 4.642 17.048 1.00 14.04 ? 359 ILE A CD1 1 ATOM 2785 N N . ASN A 1 360 ? 36.566 0.496 16.382 1.00 13.91 ? 360 ASN A N 1 ATOM 2786 C CA . ASN A 1 360 ? 35.631 -0.141 17.280 1.00 14.31 ? 360 ASN A CA 1 ATOM 2787 C C . ASN A 1 360 ? 36.298 -0.792 18.465 1.00 15.16 ? 360 ASN A C 1 ATOM 2788 O O . ASN A 1 360 ? 37.022 -1.796 18.317 1.00 15.44 ? 360 ASN A O 1 ATOM 2789 C CB . ASN A 1 360 ? 34.869 -1.212 16.491 1.00 13.36 ? 360 ASN A CB 1 ATOM 2790 C CG . ASN A 1 360 ? 34.045 -2.123 17.358 1.00 14.61 ? 360 ASN A CG 1 ATOM 2791 O OD1 . ASN A 1 360 ? 33.394 -3.037 16.851 1.00 19.18 ? 360 ASN A OD1 1 ATOM 2792 N ND2 . ASN A 1 360 ? 34.036 -1.883 18.657 1.00 12.63 ? 360 ASN A ND2 1 ATOM 2793 N N . THR A 1 361 ? 36.031 -0.262 19.650 1.00 14.97 ? 361 THR A N 1 ATOM 2794 C CA . THR A 1 361 ? 36.463 -0.976 20.849 1.00 15.49 ? 361 THR A CA 1 ATOM 2795 C C . THR A 1 361 ? 35.234 -1.351 21.673 1.00 15.89 ? 361 THR A C 1 ATOM 2796 O O . THR A 1 361 ? 34.409 -0.508 21.990 1.00 15.53 ? 361 THR A O 1 ATOM 2797 C CB . THR A 1 361 ? 37.525 -0.154 21.638 1.00 15.17 ? 361 THR A CB 1 ATOM 2798 O OG1 . THR A 1 361 ? 38.774 -0.196 20.921 1.00 14.71 ? 361 THR A OG1 1 ATOM 2799 C CG2 . THR A 1 361 ? 37.881 -0.856 22.983 1.00 16.52 ? 361 THR A CG2 1 ATOM 2800 N N . ASN A 1 362 ? 35.076 -2.643 21.951 1.00 17.20 ? 362 ASN A N 1 ATOM 2801 C CA . ASN A 1 362 ? 33.908 -3.145 22.683 1.00 17.84 ? 362 ASN A CA 1 ATOM 2802 C C . ASN A 1 362 ? 32.566 -2.714 22.079 1.00 17.75 ? 362 ASN A C 1 ATOM 2803 O O . ASN A 1 362 ? 31.549 -2.592 22.808 1.00 18.47 ? 362 ASN A O 1 ATOM 2804 C CB . ASN A 1 362 ? 33.995 -2.757 24.158 1.00 18.35 ? 362 ASN A CB 1 ATOM 2805 C CG . ASN A 1 362 ? 35.178 -3.397 24.852 1.00 21.76 ? 362 ASN A CG 1 ATOM 2806 O OD1 . ASN A 1 362 ? 35.437 -4.595 24.689 1.00 26.03 ? 362 ASN A OD1 1 ATOM 2807 N ND2 . ASN A 1 362 ? 35.909 -2.606 25.624 1.00 22.04 ? 362 ASN A ND2 1 ATOM 2808 N N . ASP A 1 363 ? 32.551 -2.501 20.767 1.00 15.91 ? 363 ASP A N 1 ATOM 2809 C CA . ASP A 1 363 ? 31.311 -2.157 20.048 1.00 15.60 ? 363 ASP A CA 1 ATOM 2810 C C . ASP A 1 363 ? 30.767 -0.775 20.387 1.00 15.13 ? 363 ASP A C 1 ATOM 2811 O O . ASP A 1 363 ? 29.530 -0.520 20.421 1.00 14.85 ? 363 ASP A O 1 ATOM 2812 C CB . ASP A 1 363 ? 30.241 -3.235 20.235 1.00 15.97 ? 363 ASP A CB 1 ATOM 2813 C CG . ASP A 1 363 ? 30.612 -4.553 19.528 1.00 17.64 ? 363 ASP A CG 1 ATOM 2814 O OD1 . ASP A 1 363 ? 31.601 -4.598 18.756 1.00 19.08 ? 363 ASP A OD1 1 ATOM 2815 O OD2 . ASP A 1 363 ? 29.981 -5.603 19.676 1.00 19.14 ? 363 ASP A OD2 1 ATOM 2816 N N . VAL A 1 364 ? 31.707 0.103 20.699 1.00 13.76 ? 364 VAL A N 1 ATOM 2817 C CA . VAL A 1 364 ? 31.439 1.503 20.834 1.00 12.86 ? 364 VAL A CA 1 ATOM 2818 C C . VAL A 1 364 ? 32.291 2.063 19.711 1.00 11.96 ? 364 VAL A C 1 ATOM 2819 O O . VAL A 1 364 ? 33.499 1.840 19.664 1.00 12.58 ? 364 VAL A O 1 ATOM 2820 C CB . VAL A 1 364 ? 31.960 2.072 22.164 1.00 13.58 ? 364 VAL A CB 1 ATOM 2821 C CG1 . VAL A 1 364 ? 31.337 3.460 22.415 1.00 12.90 ? 364 VAL A CG1 1 ATOM 2822 C CG2 . VAL A 1 364 ? 31.703 1.111 23.354 1.00 11.53 ? 364 VAL A CG2 1 ATOM 2823 N N . TYR A 1 365 ? 31.697 2.802 18.810 1.00 12.77 ? 365 TYR A N 1 ATOM 2824 C CA . TYR A 1 365 ? 32.435 3.235 17.621 1.00 13.05 ? 365 TYR A CA 1 ATOM 2825 C C . TYR A 1 365 ? 32.746 4.726 17.466 1.00 12.64 ? 365 TYR A C 1 ATOM 2826 O O . TYR A 1 365 ? 31.921 5.573 17.766 1.00 12.65 ? 365 TYR A O 1 ATOM 2827 C CB . TYR A 1 365 ? 31.729 2.796 16.322 1.00 13.07 ? 365 TYR A CB 1 ATOM 2828 C CG . TYR A 1 365 ? 31.398 1.321 16.143 1.00 14.83 ? 365 TYR A CG 1 ATOM 2829 C CD1 . TYR A 1 365 ? 30.576 0.645 17.046 1.00 15.49 ? 365 TYR A CD1 1 ATOM 2830 C CD2 . TYR A 1 365 ? 31.864 0.621 15.035 1.00 15.47 ? 365 TYR A CD2 1 ATOM 2831 C CE1 . TYR A 1 365 ? 30.264 -0.688 16.876 1.00 14.36 ? 365 TYR A CE1 1 ATOM 2832 C CE2 . TYR A 1 365 ? 31.555 -0.711 14.844 1.00 15.15 ? 365 TYR A CE2 1 ATOM 2833 C CZ . TYR A 1 365 ? 30.747 -1.356 15.764 1.00 16.77 ? 365 TYR A CZ 1 ATOM 2834 O OH . TYR A 1 365 ? 30.416 -2.678 15.570 1.00 15.67 ? 365 TYR A OH 1 ATOM 2835 N N . SER A 1 366 ? 33.949 5.019 16.964 1.00 12.02 ? 366 SER A N 1 ATOM 2836 C CA . SER A 1 366 ? 34.336 6.394 16.584 1.00 12.59 ? 366 SER A CA 1 ATOM 2837 C C . SER A 1 366 ? 34.651 6.426 15.089 1.00 12.17 ? 366 SER A C 1 ATOM 2838 O O . SER A 1 366 ? 34.900 5.401 14.504 1.00 12.21 ? 366 SER A O 1 ATOM 2839 C CB . SER A 1 366 ? 35.642 6.825 17.278 1.00 12.64 ? 366 SER A CB 1 ATOM 2840 O OG . SER A 1 366 ? 35.488 7.136 18.657 1.00 12.09 ? 366 SER A OG 1 ATOM 2841 N N . LEU A 1 367 ? 34.683 7.606 14.484 1.00 12.60 ? 367 LEU A N 1 ATOM 2842 C CA . LEU A 1 367 ? 35.184 7.739 13.115 1.00 12.16 ? 367 LEU A CA 1 ATOM 2843 C C . LEU A 1 367 ? 36.521 8.494 13.185 1.00 13.07 ? 367 LEU A C 1 ATOM 2844 O O . LEU A 1 367 ? 36.597 9.594 13.763 1.00 14.06 ? 367 LEU A O 1 ATOM 2845 C CB . LEU A 1 367 ? 34.179 8.539 12.261 1.00 12.29 ? 367 LEU A CB 1 ATOM 2846 C CG . LEU A 1 367 ? 32.762 7.933 12.311 1.00 11.94 ? 367 LEU A CG 1 ATOM 2847 C CD1 . LEU A 1 367 ? 31.780 8.747 11.499 1.00 12.54 ? 367 LEU A CD1 1 ATOM 2848 C CD2 . LEU A 1 367 ? 32.767 6.487 11.833 1.00 12.55 ? 367 LEU A CD2 1 ATOM 2849 N N . VAL A 1 368 ? 37.578 7.929 12.623 1.00 12.19 ? 368 VAL A N 1 ATOM 2850 C CA . VAL A 1 368 ? 38.821 8.649 12.574 1.00 11.88 ? 368 VAL A CA 1 ATOM 2851 C C . VAL A 1 368 ? 38.969 9.302 11.202 1.00 12.95 ? 368 VAL A C 1 ATOM 2852 O O . VAL A 1 368 ? 38.517 8.733 10.189 1.00 12.27 ? 368 VAL A O 1 ATOM 2853 C CB . VAL A 1 368 ? 40.028 7.750 12.883 1.00 11.51 ? 368 VAL A CB 1 ATOM 2854 C CG1 . VAL A 1 368 ? 40.021 7.353 14.384 1.00 13.18 ? 368 VAL A CG1 1 ATOM 2855 C CG2 . VAL A 1 368 ? 40.064 6.517 11.969 1.00 9.19 ? 368 VAL A CG2 1 ATOM 2856 N N . PHE A 1 369 ? 39.616 10.478 11.178 1.00 12.97 ? 369 PHE A N 1 ATOM 2857 C CA . PHE A 1 369 ? 39.827 11.258 9.965 1.00 13.78 ? 369 PHE A CA 1 ATOM 2858 C C . PHE A 1 369 ? 41.306 11.263 9.747 1.00 14.26 ? 369 PHE A C 1 ATOM 2859 O O . PHE A 1 369 ? 42.081 11.792 10.561 1.00 14.70 ? 369 PHE A O 1 ATOM 2860 C CB . PHE A 1 369 ? 39.248 12.665 10.113 1.00 13.84 ? 369 PHE A CB 1 ATOM 2861 C CG . PHE A 1 369 ? 39.788 13.681 9.103 1.00 14.92 ? 369 PHE A CG 1 ATOM 2862 C CD1 . PHE A 1 369 ? 39.379 13.659 7.774 1.00 11.57 ? 369 PHE A CD1 1 ATOM 2863 C CD2 . PHE A 1 369 ? 40.659 14.685 9.510 1.00 13.84 ? 369 PHE A CD2 1 ATOM 2864 C CE1 . PHE A 1 369 ? 39.851 14.567 6.869 1.00 13.20 ? 369 PHE A CE1 1 ATOM 2865 C CE2 . PHE A 1 369 ? 41.145 15.620 8.574 1.00 15.42 ? 369 PHE A CE2 1 ATOM 2866 C CZ . PHE A 1 369 ? 40.731 15.558 7.262 1.00 13.75 ? 369 PHE A CZ 1 ATOM 2867 N N . VAL A 1 370 ? 41.695 10.654 8.633 1.00 14.18 ? 370 VAL A N 1 ATOM 2868 C CA . VAL A 1 370 ? 43.064 10.271 8.421 1.00 13.69 ? 370 VAL A CA 1 ATOM 2869 C C . VAL A 1 370 ? 43.699 10.980 7.256 1.00 14.45 ? 370 VAL A C 1 ATOM 2870 O O . VAL A 1 370 ? 43.091 11.151 6.222 1.00 15.09 ? 370 VAL A O 1 ATOM 2871 C CB . VAL A 1 370 ? 43.091 8.765 8.090 1.00 14.36 ? 370 VAL A CB 1 ATOM 2872 C CG1 . VAL A 1 370 ? 44.521 8.210 8.035 1.00 12.03 ? 370 VAL A CG1 1 ATOM 2873 C CG2 . VAL A 1 370 ? 42.236 7.979 9.080 1.00 12.94 ? 370 VAL A CG2 1 ATOM 2874 N N . ARG A 1 371 ? 44.945 11.362 7.421 1.00 14.70 ? 371 ARG A N 1 ATOM 2875 C CA . ARG A 1 371 ? 45.673 12.020 6.374 1.00 15.46 ? 371 ARG A CA 1 ATOM 2876 C C . ARG A 1 371 ? 46.632 10.998 5.797 1.00 15.27 ? 371 ARG A C 1 ATOM 2877 O O . ARG A 1 371 ? 47.635 10.662 6.418 1.00 15.70 ? 371 ARG A O 1 ATOM 2878 C CB . ARG A 1 371 ? 46.430 13.228 6.958 1.00 16.25 ? 371 ARG A CB 1 ATOM 2879 C CG . ARG A 1 371 ? 45.482 14.373 7.436 1.00 19.24 ? 371 ARG A CG 1 ATOM 2880 C CD . ARG A 1 371 ? 46.246 15.550 8.037 1.00 23.32 ? 371 ARG A CD 1 ATOM 2881 N NE . ARG A 1 371 ? 45.399 16.504 8.741 1.00 28.07 ? 371 ARG A NE 1 ATOM 2882 C CZ . ARG A 1 371 ? 44.706 17.497 8.160 1.00 30.02 ? 371 ARG A CZ 1 ATOM 2883 N NH1 . ARG A 1 371 ? 44.734 17.683 6.838 1.00 28.67 ? 371 ARG A NH1 1 ATOM 2884 N NH2 . ARG A 1 371 ? 43.985 18.316 8.912 1.00 29.61 ? 371 ARG A NH2 1 ATOM 2885 N N . PHE A 1 372 ? 46.316 10.489 4.610 1.00 14.52 ? 372 PHE A N 1 ATOM 2886 C CA . PHE A 1 372 ? 47.149 9.480 3.988 1.00 14.85 ? 372 PHE A CA 1 ATOM 2887 C C . PHE A 1 372 ? 48.312 10.041 3.228 1.00 14.27 ? 372 PHE A C 1 ATOM 2888 O O . PHE A 1 372 ? 48.327 9.936 2.007 1.00 13.39 ? 372 PHE A O 1 ATOM 2889 C CB . PHE A 1 372 ? 46.330 8.774 2.951 1.00 14.93 ? 372 PHE A CB 1 ATOM 2890 C CG . PHE A 1 372 ? 45.319 7.919 3.524 1.00 17.86 ? 372 PHE A CG 1 ATOM 2891 C CD1 . PHE A 1 372 ? 44.113 7.743 2.892 1.00 18.00 ? 372 PHE A CD1 1 ATOM 2892 C CD2 . PHE A 1 372 ? 45.596 7.255 4.696 1.00 19.44 ? 372 PHE A CD2 1 ATOM 2893 C CE1 . PHE A 1 372 ? 43.221 6.943 3.410 1.00 22.98 ? 372 PHE A CE1 1 ATOM 2894 C CE2 . PHE A 1 372 ? 44.731 6.439 5.232 1.00 21.66 ? 372 PHE A CE2 1 ATOM 2895 C CZ . PHE A 1 372 ? 43.498 6.276 4.610 1.00 27.14 ? 372 PHE A CZ 1 ATOM 2896 N N . ILE A 1 373 ? 49.258 10.629 3.942 1.00 14.12 ? 373 ILE A N 1 ATOM 2897 C CA . ILE A 1 373 ? 50.456 11.172 3.351 1.00 13.26 ? 373 ILE A CA 1 ATOM 2898 C C . ILE A 1 373 ? 51.334 10.085 2.740 1.00 12.96 ? 373 ILE A C 1 ATOM 2899 O O . ILE A 1 373 ? 51.774 10.204 1.591 1.00 13.31 ? 373 ILE A O 1 ATOM 2900 C CB . ILE A 1 373 ? 51.314 11.905 4.443 1.00 13.82 ? 373 ILE A CB 1 ATOM 2901 C CG1 . ILE A 1 373 ? 50.511 12.998 5.134 1.00 16.05 ? 373 ILE A CG1 1 ATOM 2902 C CG2 . ILE A 1 373 ? 52.701 12.413 3.877 1.00 9.19 ? 373 ILE A CG2 1 ATOM 2903 C CD1 . ILE A 1 373 ? 49.449 13.466 4.309 1.00 20.94 ? 373 ILE A CD1 1 ATOM 2904 N N . GLY A 1 374 ? 51.683 9.073 3.529 1.00 12.07 ? 374 GLY A N 1 ATOM 2905 C CA . GLY A 1 374 ? 52.613 8.075 3.018 1.00 11.30 ? 374 GLY A CA 1 ATOM 2906 C C . GLY A 1 374 ? 51.991 7.204 1.933 1.00 11.24 ? 374 GLY A C 1 ATOM 2907 O O . GLY A 1 374 ? 52.630 6.829 0.954 1.00 11.27 ? 374 GLY A O 1 ATOM 2908 N N . GLU A 1 375 ? 50.727 6.881 2.132 1.00 10.63 ? 375 GLU A N 1 ATOM 2909 C CA . GLU A 1 375 ? 49.966 6.127 1.150 1.00 11.14 ? 375 GLU A CA 1 ATOM 2910 C C . GLU A 1 375 ? 49.987 6.802 -0.240 1.00 10.55 ? 375 GLU A C 1 ATOM 2911 O O . GLU A 1 375 ? 50.368 6.202 -1.223 1.00 8.96 ? 375 GLU A O 1 ATOM 2912 C CB . GLU A 1 375 ? 48.555 5.920 1.679 1.00 10.09 ? 375 GLU A CB 1 ATOM 2913 C CG . GLU A 1 375 ? 48.474 4.857 2.770 1.00 11.14 ? 375 GLU A CG 1 ATOM 2914 C CD . GLU A 1 375 ? 48.657 5.423 4.189 1.00 15.63 ? 375 GLU A CD 1 ATOM 2915 O OE1 . GLU A 1 375 ? 48.760 6.672 4.327 1.00 13.09 ? 375 GLU A OE1 1 ATOM 2916 O OE2 . GLU A 1 375 ? 48.676 4.610 5.169 1.00 12.00 ? 375 GLU A OE2 1 ATOM 2917 N N . LEU A 1 376 ? 49.615 8.075 -0.290 1.00 11.79 ? 376 LEU A N 1 ATOM 2918 C CA . LEU A 1 376 ? 49.598 8.826 -1.536 1.00 12.65 ? 376 LEU A CA 1 ATOM 2919 C C . LEU A 1 376 ? 51.005 8.860 -2.165 1.00 13.38 ? 376 LEU A C 1 ATOM 2920 O O . LEU A 1 376 ? 51.154 8.801 -3.385 1.00 14.30 ? 376 LEU A O 1 ATOM 2921 C CB . LEU A 1 376 ? 49.113 10.263 -1.264 1.00 12.57 ? 376 LEU A CB 1 ATOM 2922 C CG . LEU A 1 376 ? 49.032 11.137 -2.535 1.00 12.69 ? 376 LEU A CG 1 ATOM 2923 C CD1 . LEU A 1 376 ? 48.176 10.452 -3.593 1.00 9.71 ? 376 LEU A CD1 1 ATOM 2924 C CD2 . LEU A 1 376 ? 48.472 12.553 -2.277 1.00 16.36 ? 376 LEU A CD2 1 ATOM 2925 N N . GLN A 1 377 ? 52.030 8.971 -1.330 1.00 13.25 ? 377 GLN A N 1 ATOM 2926 C CA . GLN A 1 377 ? 53.391 8.960 -1.838 1.00 14.67 ? 377 GLN A CA 1 ATOM 2927 C C . GLN A 1 377 ? 53.691 7.657 -2.577 1.00 13.84 ? 377 GLN A C 1 ATOM 2928 O O . GLN A 1 377 ? 54.266 7.663 -3.677 1.00 13.07 ? 377 GLN A O 1 ATOM 2929 C CB . GLN A 1 377 ? 54.387 9.148 -0.682 1.00 15.67 ? 377 GLN A CB 1 ATOM 2930 C CG . GLN A 1 377 ? 55.857 9.222 -1.075 1.00 20.49 ? 377 GLN A CG 1 ATOM 2931 C CD . GLN A 1 377 ? 56.762 9.497 0.151 1.00 30.05 ? 377 GLN A CD 1 ATOM 2932 O OE1 . GLN A 1 377 ? 56.742 8.754 1.134 1.00 35.34 ? 377 GLN A OE1 1 ATOM 2933 N NE2 . GLN A 1 377 ? 57.515 10.584 0.095 1.00 32.00 ? 377 GLN A NE2 1 ATOM 2934 N N . LEU A 1 378 ? 53.322 6.546 -1.951 1.00 12.72 ? 378 LEU A N 1 ATOM 2935 C CA . LEU A 1 378 ? 53.525 5.256 -2.562 1.00 12.34 ? 378 LEU A CA 1 ATOM 2936 C C . LEU A 1 378 ? 52.617 5.151 -3.781 1.00 11.79 ? 378 LEU A C 1 ATOM 2937 O O . LEU A 1 378 ? 53.038 4.644 -4.824 1.00 12.45 ? 378 LEU A O 1 ATOM 2938 C CB . LEU A 1 378 ? 53.254 4.136 -1.565 1.00 12.42 ? 378 LEU A CB 1 ATOM 2939 C CG . LEU A 1 378 ? 53.370 2.656 -1.999 1.00 14.19 ? 378 LEU A CG 1 ATOM 2940 C CD1 . LEU A 1 378 ? 54.804 2.236 -2.436 1.00 12.69 ? 378 LEU A CD1 1 ATOM 2941 C CD2 . LEU A 1 378 ? 52.872 1.681 -0.895 1.00 12.48 ? 378 LEU A CD2 1 ATOM 2942 N N . MET A 1 379 ? 51.401 5.680 -3.700 1.00 10.69 ? 379 MET A N 1 ATOM 2943 C CA . MET A 1 379 ? 50.513 5.573 -4.871 1.00 10.15 ? 379 MET A CA 1 ATOM 2944 C C . MET A 1 379 ? 51.073 6.252 -6.122 1.00 9.75 ? 379 MET A C 1 ATOM 2945 O O . MET A 1 379 ? 51.069 5.683 -7.227 1.00 9.84 ? 379 MET A O 1 ATOM 2946 C CB . MET A 1 379 ? 49.107 6.073 -4.544 1.00 9.65 ? 379 MET A CB 1 ATOM 2947 C CG . MET A 1 379 ? 48.393 5.083 -3.661 1.00 9.43 ? 379 MET A CG 1 ATOM 2948 S SD . MET A 1 379 ? 47.182 5.865 -2.661 1.00 13.52 ? 379 MET A SD 1 ATOM 2949 C CE . MET A 1 379 ? 45.943 6.148 -3.890 1.00 8.06 ? 379 MET A CE 1 ATOM 2950 N N . LYS A 1 380 ? 51.581 7.459 -5.933 1.00 9.38 ? 380 LYS A N 1 ATOM 2951 C CA . LYS A 1 380 ? 52.151 8.217 -7.028 1.00 10.86 ? 380 LYS A CA 1 ATOM 2952 C C . LYS A 1 380 ? 53.359 7.487 -7.600 1.00 10.87 ? 380 LYS A C 1 ATOM 2953 O O . LYS A 1 380 ? 53.539 7.445 -8.799 1.00 12.21 ? 380 LYS A O 1 ATOM 2954 C CB . LYS A 1 380 ? 52.561 9.620 -6.547 1.00 9.82 ? 380 LYS A CB 1 ATOM 2955 C CG . LYS A 1 380 ? 51.334 10.484 -6.331 1.00 12.75 ? 380 LYS A CG 1 ATOM 2956 C CD . LYS A 1 380 ? 51.666 11.935 -6.158 1.00 15.80 ? 380 LYS A CD 1 ATOM 2957 C CE . LYS A 1 380 ? 50.424 12.726 -5.852 1.00 17.38 ? 380 LYS A CE 1 ATOM 2958 N NZ . LYS A 1 380 ? 50.818 14.161 -5.613 1.00 19.01 ? 380 LYS A NZ 1 ATOM 2959 N N . SER A 1 381 ? 54.184 6.918 -6.734 1.00 10.57 ? 381 SER A N 1 ATOM 2960 C CA . SER A 1 381 ? 55.358 6.244 -7.234 1.00 10.47 ? 381 SER A CA 1 ATOM 2961 C C . SER A 1 381 ? 54.912 5.070 -8.124 1.00 10.98 ? 381 SER A C 1 ATOM 2962 O O . SER A 1 381 ? 55.412 4.928 -9.230 1.00 10.19 ? 381 SER A O 1 ATOM 2963 C CB . SER A 1 381 ? 56.254 5.747 -6.099 1.00 10.00 ? 381 SER A CB 1 ATOM 2964 O OG . SER A 1 381 ? 57.258 4.899 -6.644 1.00 8.12 ? 381 SER A OG 1 ATOM 2965 N N . VAL A 1 382 ? 53.954 4.254 -7.657 1.00 10.28 ? 382 VAL A N 1 ATOM 2966 C CA . VAL A 1 382 ? 53.517 3.160 -8.530 1.00 10.40 ? 382 VAL A CA 1 ATOM 2967 C C . VAL A 1 382 ? 52.745 3.575 -9.788 1.00 9.85 ? 382 VAL A C 1 ATOM 2968 O O . VAL A 1 382 ? 52.871 2.946 -10.820 1.00 8.89 ? 382 VAL A O 1 ATOM 2969 C CB . VAL A 1 382 ? 52.930 1.891 -7.808 1.00 11.40 ? 382 VAL A CB 1 ATOM 2970 C CG1 . VAL A 1 382 ? 52.990 1.974 -6.325 1.00 11.14 ? 382 VAL A CG1 1 ATOM 2971 C CG2 . VAL A 1 382 ? 51.586 1.416 -8.387 1.00 8.63 ? 382 VAL A CG2 1 ATOM 2972 N N . VAL A 1 383 ? 51.987 4.649 -9.710 1.00 10.57 ? 383 VAL A N 1 ATOM 2973 C CA . VAL A 1 383 ? 51.353 5.163 -10.914 1.00 10.97 ? 383 VAL A CA 1 ATOM 2974 C C . VAL A 1 383 ? 52.437 5.569 -11.918 1.00 11.10 ? 383 VAL A C 1 ATOM 2975 O O . VAL A 1 383 ? 52.347 5.298 -13.107 1.00 11.21 ? 383 VAL A O 1 ATOM 2976 C CB . VAL A 1 383 ? 50.423 6.366 -10.622 1.00 10.75 ? 383 VAL A CB 1 ATOM 2977 C CG1 . VAL A 1 383 ? 50.089 7.069 -11.928 1.00 9.39 ? 383 VAL A CG1 1 ATOM 2978 C CG2 . VAL A 1 383 ? 49.145 5.891 -9.954 1.00 11.10 ? 383 VAL A CG2 1 ATOM 2979 N N . ARG A 1 384 ? 53.483 6.203 -11.425 1.00 11.75 ? 384 ARG A N 1 ATOM 2980 C CA . ARG A 1 384 ? 54.577 6.557 -12.313 1.00 13.39 ? 384 ARG A CA 1 ATOM 2981 C C . ARG A 1 384 ? 55.242 5.319 -12.927 1.00 12.80 ? 384 ARG A C 1 ATOM 2982 O O . ARG A 1 384 ? 55.587 5.300 -14.109 1.00 13.42 ? 384 ARG A O 1 ATOM 2983 C CB . ARG A 1 384 ? 55.601 7.408 -11.549 1.00 13.99 ? 384 ARG A CB 1 ATOM 2984 C CG . ARG A 1 384 ? 55.071 8.832 -11.297 1.00 18.50 ? 384 ARG A CG 1 ATOM 2985 C CD . ARG A 1 384 ? 56.195 9.870 -11.040 1.00 22.46 ? 384 ARG A CD 1 ATOM 2986 N NE . ARG A 1 384 ? 56.835 9.501 -9.801 1.00 25.07 ? 384 ARG A NE 1 ATOM 2987 C CZ . ARG A 1 384 ? 56.473 9.962 -8.620 1.00 25.02 ? 384 ARG A CZ 1 ATOM 2988 N NH1 . ARG A 1 384 ? 57.120 9.554 -7.545 1.00 23.18 ? 384 ARG A NH1 1 ATOM 2989 N NH2 . ARG A 1 384 ? 55.488 10.851 -8.517 1.00 25.85 ? 384 ARG A NH2 1 ATOM 2990 N N . THR A 1 385 ? 55.456 4.278 -12.138 1.00 12.10 ? 385 THR A N 1 ATOM 2991 C CA . THR A 1 385 ? 56.025 3.078 -12.743 1.00 11.83 ? 385 THR A CA 1 ATOM 2992 C C . THR A 1 385 ? 55.096 2.592 -13.900 1.00 12.07 ? 385 THR A C 1 ATOM 2993 O O . THR A 1 385 ? 55.530 2.408 -15.043 1.00 12.16 ? 385 THR A O 1 ATOM 2994 C CB . THR A 1 385 ? 56.136 2.005 -11.690 1.00 11.70 ? 385 THR A CB 1 ATOM 2995 O OG1 . THR A 1 385 ? 57.187 2.351 -10.778 1.00 11.28 ? 385 THR A OG1 1 ATOM 2996 C CG2 . THR A 1 385 ? 56.549 0.643 -12.324 1.00 9.55 ? 385 THR A CG2 1 ATOM 2997 N N . TRP A 1 386 ? 53.805 2.454 -13.614 1.00 11.37 ? 386 TRP A N 1 ATOM 2998 C CA . TRP A 1 386 ? 52.856 1.992 -14.630 1.00 11.78 ? 386 TRP A CA 1 ATOM 2999 C C . TRP A 1 386 ? 52.860 2.815 -15.932 1.00 11.97 ? 386 TRP A C 1 ATOM 3000 O O . TRP A 1 386 ? 52.825 2.259 -17.030 1.00 10.48 ? 386 TRP A O 1 ATOM 3001 C CB . TRP A 1 386 ? 51.424 1.962 -14.097 1.00 10.83 ? 386 TRP A CB 1 ATOM 3002 C CG . TRP A 1 386 ? 51.161 0.984 -12.973 1.00 10.72 ? 386 TRP A CG 1 ATOM 3003 C CD1 . TRP A 1 386 ? 52.002 0.011 -12.493 1.00 7.36 ? 386 TRP A CD1 1 ATOM 3004 C CD2 . TRP A 1 386 ? 49.960 0.901 -12.176 1.00 7.46 ? 386 TRP A CD2 1 ATOM 3005 N NE1 . TRP A 1 386 ? 51.403 -0.649 -11.443 1.00 7.84 ? 386 TRP A NE1 1 ATOM 3006 C CE2 . TRP A 1 386 ? 50.156 -0.118 -11.224 1.00 7.24 ? 386 TRP A CE2 1 ATOM 3007 C CE3 . TRP A 1 386 ? 48.757 1.618 -12.151 1.00 6.89 ? 386 TRP A CE3 1 ATOM 3008 C CZ2 . TRP A 1 386 ? 49.181 -0.458 -10.263 1.00 9.02 ? 386 TRP A CZ2 1 ATOM 3009 C CZ3 . TRP A 1 386 ? 47.798 1.294 -11.214 1.00 8.53 ? 386 TRP A CZ3 1 ATOM 3010 C CH2 . TRP A 1 386 ? 48.016 0.237 -10.278 1.00 9.23 ? 386 TRP A CH2 1 ATOM 3011 N N . LYS A 1 387 ? 52.876 4.139 -15.800 1.00 13.61 ? 387 LYS A N 1 ATOM 3012 C CA . LYS A 1 387 ? 52.783 5.008 -16.973 1.00 15.55 ? 387 LYS A CA 1 ATOM 3013 C C . LYS A 1 387 ? 54.027 4.865 -17.807 1.00 16.06 ? 387 LYS A C 1 ATOM 3014 O O . LYS A 1 387 ? 53.992 4.737 -19.056 1.00 15.85 ? 387 LYS A O 1 ATOM 3015 C CB . LYS A 1 387 ? 52.710 6.462 -16.528 1.00 16.34 ? 387 LYS A CB 1 ATOM 3016 C CG . LYS A 1 387 ? 51.361 6.857 -16.015 1.00 17.31 ? 387 LYS A CG 1 ATOM 3017 C CD . LYS A 1 387 ? 51.418 8.244 -15.362 1.00 19.97 ? 387 LYS A CD 1 ATOM 3018 C CE . LYS A 1 387 ? 51.482 9.394 -16.375 1.00 20.30 ? 387 LYS A CE 1 ATOM 3019 N NZ . LYS A 1 387 ? 52.184 10.566 -15.712 1.00 22.03 ? 387 LYS A NZ 1 ATOM 3020 N N . GLU A 1 388 ? 55.127 4.865 -17.081 1.00 15.94 ? 388 GLU A N 1 ATOM 3021 C CA . GLU A 1 388 ? 56.440 4.799 -17.687 1.00 17.07 ? 388 GLU A CA 1 ATOM 3022 C C . GLU A 1 388 ? 56.676 3.466 -18.377 1.00 15.90 ? 388 GLU A C 1 ATOM 3023 O O . GLU A 1 388 ? 57.138 3.462 -19.501 1.00 16.56 ? 388 GLU A O 1 ATOM 3024 C CB . GLU A 1 388 ? 57.549 5.173 -16.665 1.00 17.70 ? 388 GLU A CB 1 ATOM 3025 C CG . GLU A 1 388 ? 57.492 6.665 -16.233 1.00 23.74 ? 388 GLU A CG 1 ATOM 3026 C CD . GLU A 1 388 ? 58.437 7.048 -15.066 1.00 30.68 ? 388 GLU A CD 1 ATOM 3027 O OE1 . GLU A 1 388 ? 59.226 6.162 -14.591 1.00 31.31 ? 388 GLU A OE1 1 ATOM 3028 O OE2 . GLU A 1 388 ? 58.383 8.240 -14.615 1.00 30.37 ? 388 GLU A OE2 1 ATOM 3029 N N . GLU A 1 389 ? 56.381 2.335 -17.739 1.00 14.57 ? 389 GLU A N 1 ATOM 3030 C CA . GLU A 1 389 ? 56.559 1.078 -18.440 1.00 12.73 ? 389 GLU A CA 1 ATOM 3031 C C . GLU A 1 389 ? 55.596 0.975 -19.626 1.00 12.12 ? 389 GLU A C 1 ATOM 3032 O O . GLU A 1 389 ? 56.003 0.522 -20.698 1.00 10.00 ? 389 GLU A O 1 ATOM 3033 C CB . GLU A 1 389 ? 56.431 -0.136 -17.511 1.00 13.43 ? 389 GLU A CB 1 ATOM 3034 C CG . GLU A 1 389 ? 56.671 -1.503 -18.190 1.00 13.56 ? 389 GLU A CG 1 ATOM 3035 C CD . GLU A 1 389 ? 58.079 -1.675 -18.769 1.00 13.18 ? 389 GLU A CD 1 ATOM 3036 O OE1 . GLU A 1 389 ? 59.001 -0.954 -18.377 1.00 11.91 ? 389 GLU A OE1 1 ATOM 3037 O OE2 . GLU A 1 389 ? 58.270 -2.553 -19.635 1.00 16.46 ? 389 GLU A OE2 1 ATOM 3038 N N . ASP A 1 390 ? 54.336 1.398 -19.460 1.00 11.74 ? 390 ASP A N 1 ATOM 3039 C CA . ASP A 1 390 ? 53.383 1.320 -20.585 1.00 12.88 ? 390 ASP A CA 1 ATOM 3040 C C . ASP A 1 390 ? 53.845 2.219 -21.764 1.00 13.13 ? 390 ASP A C 1 ATOM 3041 O O . ASP A 1 390 ? 53.697 1.852 -22.955 1.00 12.40 ? 390 ASP A O 1 ATOM 3042 C CB . ASP A 1 390 ? 51.973 1.785 -20.187 1.00 12.69 ? 390 ASP A CB 1 ATOM 3043 C CG . ASP A 1 390 ? 51.166 0.714 -19.444 1.00 14.91 ? 390 ASP A CG 1 ATOM 3044 O OD1 . ASP A 1 390 ? 51.539 -0.474 -19.415 1.00 14.48 ? 390 ASP A OD1 1 ATOM 3045 O OD2 . ASP A 1 390 ? 50.140 0.997 -18.819 1.00 16.31 ? 390 ASP A OD2 1 ATOM 3046 N N . ASN A 1 391 ? 54.354 3.412 -21.440 1.00 13.09 ? 391 ASN A N 1 ATOM 3047 C CA . ASN A 1 391 ? 54.744 4.344 -22.523 1.00 14.20 ? 391 ASN A CA 1 ATOM 3048 C C . ASN A 1 391 ? 55.987 3.825 -23.229 1.00 13.89 ? 391 ASN A C 1 ATOM 3049 O O . ASN A 1 391 ? 56.130 3.949 -24.422 1.00 14.13 ? 391 ASN A O 1 ATOM 3050 C CB . ASN A 1 391 ? 54.986 5.747 -21.983 1.00 14.44 ? 391 ASN A CB 1 ATOM 3051 N N . HIS A 1 392 ? 56.880 3.229 -22.465 1.00 13.47 ? 392 HIS A N 1 ATOM 3052 C CA . HIS A 1 392 ? 58.078 2.675 -23.050 1.00 14.10 ? 392 HIS A CA 1 ATOM 3053 C C . HIS A 1 392 ? 57.687 1.513 -23.993 1.00 14.25 ? 392 HIS A C 1 ATOM 3054 O O . HIS A 1 392 ? 58.081 1.470 -25.158 1.00 13.85 ? 392 HIS A O 1 ATOM 3055 C CB . HIS A 1 392 ? 59.023 2.232 -21.931 1.00 13.99 ? 392 HIS A CB 1 ATOM 3056 C CG . HIS A 1 392 ? 60.136 1.361 -22.402 1.00 14.29 ? 392 HIS A CG 1 ATOM 3057 N ND1 . HIS A 1 392 ? 61.214 1.850 -23.111 1.00 16.97 ? 392 HIS A ND1 1 ATOM 3058 C CD2 . HIS A 1 392 ? 60.319 0.022 -22.313 1.00 14.94 ? 392 HIS A CD2 1 ATOM 3059 C CE1 . HIS A 1 392 ? 62.016 0.849 -23.436 1.00 18.51 ? 392 HIS A CE1 1 ATOM 3060 N NE2 . HIS A 1 392 ? 61.496 -0.273 -22.966 1.00 17.58 ? 392 HIS A NE2 1 ATOM 3061 N N . LEU A 1 393 ? 56.894 0.570 -23.511 1.00 13.20 ? 393 LEU A N 1 ATOM 3062 C CA . LEU A 1 393 ? 56.531 -0.518 -24.415 1.00 13.23 ? 393 LEU A CA 1 ATOM 3063 C C . LEU A 1 393 ? 55.756 -0.001 -25.610 1.00 13.44 ? 393 LEU A C 1 ATOM 3064 O O . LEU A 1 393 ? 55.967 -0.470 -26.726 1.00 12.30 ? 393 LEU A O 1 ATOM 3065 C CB . LEU A 1 393 ? 55.754 -1.630 -23.713 1.00 12.80 ? 393 LEU A CB 1 ATOM 3066 C CG . LEU A 1 393 ? 56.519 -2.342 -22.583 1.00 11.13 ? 393 LEU A CG 1 ATOM 3067 C CD1 . LEU A 1 393 ? 55.525 -2.999 -21.673 1.00 10.42 ? 393 LEU A CD1 1 ATOM 3068 C CD2 . LEU A 1 393 ? 57.551 -3.358 -23.153 1.00 9.90 ? 393 LEU A CD2 1 ATOM 3069 N N . ALA A 1 394 ? 54.852 0.947 -25.392 1.00 14.00 ? 394 ALA A N 1 ATOM 3070 C CA . ALA A 1 394 ? 54.043 1.452 -26.500 1.00 14.90 ? 394 ALA A CA 1 ATOM 3071 C C . ALA A 1 394 ? 54.869 2.267 -27.474 1.00 16.45 ? 394 ALA A C 1 ATOM 3072 O O . ALA A 1 394 ? 54.420 2.569 -28.581 1.00 16.15 ? 394 ALA A O 1 ATOM 3073 C CB . ALA A 1 394 ? 52.848 2.288 -26.005 1.00 15.31 ? 394 ALA A CB 1 ATOM 3074 N N . SER A 1 395 ? 56.074 2.638 -27.067 1.00 16.92 ? 395 SER A N 1 ATOM 3075 C CA . SER A 1 395 ? 56.902 3.438 -27.944 1.00 17.71 ? 395 SER A CA 1 ATOM 3076 C C . SER A 1 395 ? 57.950 2.723 -28.760 1.00 16.77 ? 395 SER A C 1 ATOM 3077 O O . SER A 1 395 ? 58.632 3.355 -29.592 1.00 16.46 ? 395 SER A O 1 ATOM 3078 C CB . SER A 1 395 ? 57.531 4.587 -27.165 1.00 17.80 ? 395 SER A CB 1 ATOM 3079 O OG . SER A 1 395 ? 56.510 5.515 -26.833 1.00 23.32 ? 395 SER A OG 1 ATOM 3080 N N . ILE A 1 396 ? 58.079 1.429 -28.523 1.00 15.23 ? 396 ILE A N 1 ATOM 3081 C CA . ILE A 1 396 ? 59.016 0.609 -29.253 1.00 14.68 ? 396 ILE A CA 1 ATOM 3082 C C . ILE A 1 396 ? 58.595 0.485 -30.732 1.00 14.25 ? 396 ILE A C 1 ATOM 3083 O O . ILE A 1 396 ? 57.423 0.271 -31.023 1.00 12.35 ? 396 ILE A O 1 ATOM 3084 C CB . ILE A 1 396 ? 59.055 -0.804 -28.620 1.00 14.36 ? 396 ILE A CB 1 ATOM 3085 C CG1 . ILE A 1 396 ? 59.808 -0.769 -27.284 1.00 13.89 ? 396 ILE A CG1 1 ATOM 3086 C CG2 . ILE A 1 396 ? 59.635 -1.821 -29.641 1.00 13.35 ? 396 ILE A CG2 1 ATOM 3087 C CD1 . ILE A 1 396 ? 59.666 -2.073 -26.456 1.00 12.17 ? 396 ILE A CD1 1 ATOM 3088 N N . CYS A 1 397 ? 59.569 0.598 -31.632 1.00 13.59 ? 397 CYS A N 1 ATOM 3089 C CA . CYS A 1 397 ? 59.353 0.447 -33.051 1.00 13.65 ? 397 CYS A CA 1 ATOM 3090 C C . CYS A 1 397 ? 59.475 -1.017 -33.423 1.00 12.91 ? 397 CYS A C 1 ATOM 3091 O O . CYS A 1 397 ? 60.577 -1.555 -33.496 1.00 13.68 ? 397 CYS A O 1 ATOM 3092 C CB . CYS A 1 397 ? 60.381 1.283 -33.840 1.00 14.30 ? 397 CYS A CB 1 ATOM 3093 S SG . CYS A 1 397 ? 60.076 1.365 -35.664 1.00 16.20 ? 397 CYS A SG 1 ATOM 3094 N N . THR A 1 398 ? 58.355 -1.688 -33.643 1.00 12.99 ? 398 THR A N 1 ATOM 3095 C CA . THR A 1 398 ? 58.396 -3.111 -33.960 1.00 12.65 ? 398 THR A CA 1 ATOM 3096 C C . THR A 1 398 ? 58.460 -3.291 -35.484 1.00 13.18 ? 398 THR A C 1 ATOM 3097 O O . THR A 1 398 ? 58.113 -2.383 -36.263 1.00 11.66 ? 398 THR A O 1 ATOM 3098 C CB . THR A 1 398 ? 57.171 -3.858 -33.442 1.00 12.56 ? 398 THR A CB 1 ATOM 3099 O OG1 . THR A 1 398 ? 56.058 -3.495 -34.253 1.00 12.42 ? 398 THR A OG1 1 ATOM 3100 C CG2 . THR A 1 398 ? 56.808 -3.452 -31.937 1.00 9.20 ? 398 THR A CG2 1 ATOM 3101 N N . PRO A 1 399 ? 58.911 -4.461 -35.894 1.00 12.16 ? 399 PRO A N 1 ATOM 3102 C CA . PRO A 1 399 ? 59.132 -4.717 -37.317 1.00 13.10 ? 399 PRO A CA 1 ATOM 3103 C C . PRO A 1 399 ? 57.866 -4.599 -38.156 1.00 13.95 ? 399 PRO A C 1 ATOM 3104 O O . PRO A 1 399 ? 56.800 -5.093 -37.764 1.00 14.71 ? 399 PRO A O 1 ATOM 3105 C CB . PRO A 1 399 ? 59.724 -6.142 -37.344 1.00 12.84 ? 399 PRO A CB 1 ATOM 3106 C CG . PRO A 1 399 ? 60.383 -6.337 -35.956 1.00 13.04 ? 399 PRO A CG 1 ATOM 3107 C CD . PRO A 1 399 ? 59.354 -5.567 -35.026 1.00 12.75 ? 399 PRO A CD 1 ATOM 3108 N N . VAL A 1 400 ? 57.969 -3.910 -39.281 1.00 14.70 ? 400 VAL A N 1 ATOM 3109 C CA . VAL A 1 400 ? 56.852 -3.854 -40.201 1.00 15.05 ? 400 VAL A CA 1 ATOM 3110 C C . VAL A 1 400 ? 56.645 -5.234 -40.856 1.00 16.64 ? 400 VAL A C 1 ATOM 3111 O O . VAL A 1 400 ? 57.600 -5.850 -41.314 1.00 14.78 ? 400 VAL A O 1 ATOM 3112 C CB . VAL A 1 400 ? 57.079 -2.821 -41.328 1.00 15.81 ? 400 VAL A CB 1 ATOM 3113 C CG1 . VAL A 1 400 ? 55.867 -2.844 -42.315 1.00 13.07 ? 400 VAL A CG1 1 ATOM 3114 C CG2 . VAL A 1 400 ? 57.288 -1.406 -40.772 1.00 13.14 ? 400 VAL A CG2 1 ATOM 3115 N N . VAL A 1 401 ? 55.405 -5.713 -40.896 1.00 17.52 ? 401 VAL A N 1 ATOM 3116 C CA . VAL A 1 401 ? 55.140 -6.993 -41.520 1.00 20.67 ? 401 VAL A CA 1 ATOM 3117 C C . VAL A 1 401 ? 54.661 -6.873 -42.969 1.00 21.28 ? 401 VAL A C 1 ATOM 3118 O O . VAL A 1 401 ? 53.945 -5.957 -43.311 1.00 20.13 ? 401 VAL A O 1 ATOM 3119 C CB . VAL A 1 401 ? 54.102 -7.764 -40.727 1.00 21.74 ? 401 VAL A CB 1 ATOM 3120 C CG1 . VAL A 1 401 ? 54.414 -9.226 -40.859 1.00 25.07 ? 401 VAL A CG1 1 ATOM 3121 C CG2 . VAL A 1 401 ? 54.190 -7.399 -39.226 1.00 23.69 ? 401 VAL A CG2 1 ATOM 3122 N N . PRO A 1 402 ? 55.068 -7.797 -43.825 1.00 23.13 ? 402 PRO A N 1 ATOM 3123 C CA . PRO A 1 402 ? 54.678 -7.762 -45.244 1.00 24.99 ? 402 PRO A CA 1 ATOM 3124 C C . PRO A 1 402 ? 53.163 -7.707 -45.386 1.00 26.58 ? 402 PRO A C 1 ATOM 3125 O O . PRO A 1 402 ? 52.504 -8.423 -44.659 1.00 26.79 ? 402 PRO A O 1 ATOM 3126 C CB . PRO A 1 402 ? 55.195 -9.101 -45.809 1.00 24.55 ? 402 PRO A CB 1 ATOM 3127 C CG . PRO A 1 402 ? 56.137 -9.630 -44.851 1.00 24.19 ? 402 PRO A CG 1 ATOM 3128 C CD . PRO A 1 402 ? 55.935 -8.938 -43.505 1.00 23.79 ? 402 PRO A CD 1 ATOM 3129 N N . ALA A 1 403 ? 52.609 -6.864 -46.255 1.00 28.62 ? 403 ALA A N 1 ATOM 3130 C CA . ALA A 1 403 ? 51.139 -6.840 -46.390 1.00 30.97 ? 403 ALA A CA 1 ATOM 3131 C C . ALA A 1 403 ? 50.650 -7.112 -47.825 1.00 31.93 ? 403 ALA A C 1 ATOM 3132 O O . ALA A 1 403 ? 50.111 -6.226 -48.527 1.00 33.62 ? 403 ALA A O 1 ATOM 3133 C CB . ALA A 1 403 ? 50.519 -5.537 -45.799 1.00 30.96 ? 403 ALA A CB 1 ATOM 3134 N N . GLY A 1 410 ? 56.941 3.469 -40.611 1.00 23.03 ? 410 GLY A N 1 ATOM 3135 C CA . GLY A 1 410 ? 58.301 3.016 -40.246 1.00 22.51 ? 410 GLY A CA 1 ATOM 3136 C C . GLY A 1 410 ? 58.266 1.781 -39.295 1.00 21.38 ? 410 GLY A C 1 ATOM 3137 O O . GLY A 1 410 ? 59.247 1.043 -39.141 1.00 19.47 ? 410 GLY A O 1 ATOM 3138 N N . CYS A 1 411 ? 57.116 1.585 -38.662 1.00 19.31 ? 411 CYS A N 1 ATOM 3139 C CA . CYS A 1 411 ? 57.025 0.615 -37.580 1.00 18.07 ? 411 CYS A CA 1 ATOM 3140 C C . CYS A 1 411 ? 55.786 -0.231 -37.731 1.00 16.70 ? 411 CYS A C 1 ATOM 3141 O O . CYS A 1 411 ? 54.826 0.202 -38.358 1.00 16.10 ? 411 CYS A O 1 ATOM 3142 C CB . CYS A 1 411 ? 56.982 1.363 -36.251 1.00 17.59 ? 411 CYS A CB 1 ATOM 3143 S SG . CYS A 1 411 ? 58.405 2.474 -35.976 1.00 20.60 ? 411 CYS A SG 1 ATOM 3144 N N . GLY A 1 412 ? 55.810 -1.433 -37.154 1.00 15.28 ? 412 GLY A N 1 ATOM 3145 C CA . GLY A 1 412 ? 54.656 -2.310 -37.190 1.00 14.53 ? 412 GLY A CA 1 ATOM 3146 C C . GLY A 1 412 ? 53.680 -1.970 -36.079 1.00 13.83 ? 412 GLY A C 1 ATOM 3147 O O . GLY A 1 412 ? 53.806 -0.943 -35.401 1.00 12.79 ? 412 GLY A O 1 ATOM 3148 N N . ALA A 1 413 ? 52.691 -2.824 -35.877 1.00 13.07 ? 413 ALA A N 1 ATOM 3149 C CA . ALA A 1 413 ? 51.795 -2.596 -34.725 1.00 13.63 ? 413 ALA A CA 1 ATOM 3150 C C . ALA A 1 413 ? 52.561 -2.469 -33.392 1.00 12.74 ? 413 ALA A C 1 ATOM 3151 O O . ALA A 1 413 ? 53.614 -3.087 -33.193 1.00 12.15 ? 413 ALA A O 1 ATOM 3152 C CB . ALA A 1 413 ? 50.722 -3.721 -34.635 1.00 12.13 ? 413 ALA A CB 1 ATOM 3153 N N . ALA A 1 414 ? 52.031 -1.651 -32.497 1.00 12.89 ? 414 ALA A N 1 ATOM 3154 C CA . ALA A 1 414 ? 52.598 -1.477 -31.153 1.00 12.72 ? 414 ALA A CA 1 ATOM 3155 C C . ALA A 1 414 ? 52.638 -2.763 -30.304 1.00 12.24 ? 414 ALA A C 1 ATOM 3156 O O . ALA A 1 414 ? 51.784 -3.645 -30.424 1.00 10.61 ? 414 ALA A O 1 ATOM 3157 C CB . ALA A 1 414 ? 51.784 -0.409 -30.393 1.00 13.03 ? 414 ALA A CB 1 ATOM 3158 N N . VAL A 1 415 ? 53.653 -2.860 -29.460 1.00 12.16 ? 415 VAL A N 1 ATOM 3159 C CA . VAL A 1 415 ? 53.718 -3.924 -28.483 1.00 11.45 ? 415 VAL A CA 1 ATOM 3160 C C . VAL A 1 415 ? 52.425 -3.789 -27.672 1.00 12.28 ? 415 VAL A C 1 ATOM 3161 O O . VAL A 1 415 ? 52.161 -2.738 -27.128 1.00 13.64 ? 415 VAL A O 1 ATOM 3162 C CB . VAL A 1 415 ? 54.976 -3.763 -27.583 1.00 12.09 ? 415 VAL A CB 1 ATOM 3163 C CG1 . VAL A 1 415 ? 55.010 -4.872 -26.528 1.00 9.21 ? 415 VAL A CG1 1 ATOM 3164 C CG2 . VAL A 1 415 ? 56.293 -3.798 -28.429 1.00 8.30 ? 415 VAL A CG2 1 ATOM 3165 N N . PRO A 1 416 ? 51.594 -4.823 -27.601 1.00 11.91 ? 416 PRO A N 1 ATOM 3166 C CA . PRO A 1 416 ? 50.317 -4.691 -26.885 1.00 11.74 ? 416 PRO A CA 1 ATOM 3167 C C . PRO A 1 416 ? 50.507 -4.398 -25.403 1.00 11.51 ? 416 PRO A C 1 ATOM 3168 O O . PRO A 1 416 ? 51.185 -5.158 -24.754 1.00 10.99 ? 416 PRO A O 1 ATOM 3169 C CB . PRO A 1 416 ? 49.670 -6.083 -27.029 1.00 14.18 ? 416 PRO A CB 1 ATOM 3170 C CG . PRO A 1 416 ? 50.411 -6.808 -28.124 1.00 13.28 ? 416 PRO A CG 1 ATOM 3171 C CD . PRO A 1 416 ? 51.798 -6.169 -28.161 1.00 11.16 ? 416 PRO A CD 1 ATOM 3172 N N . THR A 1 417 ? 49.888 -3.336 -24.901 1.00 10.50 ? 417 THR A N 1 ATOM 3173 C CA . THR A 1 417 ? 49.896 -2.992 -23.497 1.00 10.87 ? 417 THR A CA 1 ATOM 3174 C C . THR A 1 417 ? 48.455 -3.011 -22.894 1.00 11.00 ? 417 THR A C 1 ATOM 3175 O O . THR A 1 417 ? 48.303 -3.105 -21.695 1.00 12.33 ? 417 THR A O 1 ATOM 3176 C CB . THR A 1 417 ? 50.552 -1.597 -23.281 1.00 10.19 ? 417 THR A CB 1 ATOM 3177 O OG1 . THR A 1 417 ? 49.887 -0.645 -24.125 1.00 11.21 ? 417 THR A OG1 1 ATOM 3178 C CG2 . THR A 1 417 ? 51.972 -1.560 -23.824 1.00 7.69 ? 417 THR A CG2 1 ATOM 3179 N N . ALA A 1 418 ? 47.403 -2.927 -23.699 1.00 10.88 ? 418 ALA A N 1 ATOM 3180 C CA . ALA A 1 418 ? 46.044 -2.987 -23.134 1.00 10.36 ? 418 ALA A CA 1 ATOM 3181 C C . ALA A 1 418 ? 45.903 -4.343 -22.529 1.00 10.44 ? 418 ALA A C 1 ATOM 3182 O O . ALA A 1 418 ? 46.145 -5.338 -23.212 1.00 10.11 ? 418 ALA A O 1 ATOM 3183 C CB . ALA A 1 418 ? 44.961 -2.856 -24.249 1.00 10.21 ? 418 ALA A CB 1 ATOM 3184 N N . GLY A 1 419 ? 45.472 -4.410 -21.276 1.00 10.48 ? 419 GLY A N 1 ATOM 3185 C CA . GLY A 1 419 ? 45.241 -5.707 -20.654 1.00 10.02 ? 419 GLY A CA 1 ATOM 3186 C C . GLY A 1 419 ? 46.505 -6.357 -20.114 1.00 9.54 ? 419 GLY A C 1 ATOM 3187 O O . GLY A 1 419 ? 46.465 -7.491 -19.635 1.00 9.57 ? 419 GLY A O 1 ATOM 3188 N N . LEU A 1 420 ? 47.622 -5.642 -20.206 1.00 9.04 ? 420 LEU A N 1 ATOM 3189 C CA . LEU A 1 420 ? 48.906 -6.140 -19.710 1.00 9.44 ? 420 LEU A CA 1 ATOM 3190 C C . LEU A 1 420 ? 48.901 -6.030 -18.185 1.00 9.62 ? 420 LEU A C 1 ATOM 3191 O O . LEU A 1 420 ? 48.946 -4.935 -17.653 1.00 10.10 ? 420 LEU A O 1 ATOM 3192 C CB . LEU A 1 420 ? 50.059 -5.309 -20.300 1.00 8.37 ? 420 LEU A CB 1 ATOM 3193 C CG . LEU A 1 420 ? 51.426 -6.034 -20.330 1.00 10.46 ? 420 LEU A CG 1 ATOM 3194 C CD1 . LEU A 1 420 ? 52.485 -5.235 -21.156 1.00 8.28 ? 420 LEU A CD1 1 ATOM 3195 C CD2 . LEU A 1 420 ? 51.994 -6.343 -18.903 1.00 9.25 ? 420 LEU A CD2 1 ATOM 3196 N N . VAL A 1 421 ? 48.868 -7.166 -17.497 1.00 9.64 ? 421 VAL A N 1 ATOM 3197 C CA . VAL A 1 421 ? 48.735 -7.195 -16.047 1.00 9.36 ? 421 VAL A CA 1 ATOM 3198 C C . VAL A 1 421 ? 50.047 -7.304 -15.260 1.00 9.27 ? 421 VAL A C 1 ATOM 3199 O O . VAL A 1 421 ? 50.214 -6.605 -14.279 1.00 8.95 ? 421 VAL A O 1 ATOM 3200 C CB . VAL A 1 421 ? 47.807 -8.369 -15.623 1.00 9.07 ? 421 VAL A CB 1 ATOM 3201 C CG1 . VAL A 1 421 ? 47.934 -8.659 -14.107 1.00 8.01 ? 421 VAL A CG1 1 ATOM 3202 C CG2 . VAL A 1 421 ? 46.389 -8.055 -16.024 1.00 6.85 ? 421 VAL A CG2 1 ATOM 3203 N N . GLY A 1 422 ? 50.922 -8.228 -15.653 1.00 8.79 ? 422 GLY A N 1 ATOM 3204 C CA . GLY A 1 422 ? 52.188 -8.456 -14.984 1.00 8.93 ? 422 GLY A CA 1 ATOM 3205 C C . GLY A 1 422 ? 53.336 -8.707 -15.985 1.00 9.81 ? 422 GLY A C 1 ATOM 3206 O O . GLY A 1 422 ? 53.084 -9.081 -17.119 1.00 9.03 ? 422 GLY A O 1 ATOM 3207 N N . PHE A 1 423 ? 54.583 -8.522 -15.541 1.00 9.73 ? 423 PHE A N 1 ATOM 3208 C CA . PHE A 1 423 ? 55.748 -8.645 -16.408 1.00 9.75 ? 423 PHE A CA 1 ATOM 3209 C C . PHE A 1 423 ? 56.955 -9.002 -15.523 1.00 9.41 ? 423 PHE A C 1 ATOM 3210 O O . PHE A 1 423 ? 57.268 -8.324 -14.555 1.00 10.43 ? 423 PHE A O 1 ATOM 3211 C CB . PHE A 1 423 ? 55.929 -7.310 -17.150 1.00 9.31 ? 423 PHE A CB 1 ATOM 3212 C CG . PHE A 1 423 ? 57.028 -7.313 -18.198 1.00 9.07 ? 423 PHE A CG 1 ATOM 3213 C CD1 . PHE A 1 423 ? 57.656 -6.126 -18.573 1.00 8.96 ? 423 PHE A CD1 1 ATOM 3214 C CD2 . PHE A 1 423 ? 57.392 -8.467 -18.815 1.00 6.28 ? 423 PHE A CD2 1 ATOM 3215 C CE1 . PHE A 1 423 ? 58.667 -6.124 -19.562 1.00 10.05 ? 423 PHE A CE1 1 ATOM 3216 C CE2 . PHE A 1 423 ? 58.377 -8.482 -19.786 1.00 9.55 ? 423 PHE A CE2 1 ATOM 3217 C CZ . PHE A 1 423 ? 59.013 -7.312 -20.158 1.00 9.87 ? 423 PHE A CZ 1 ATOM 3218 N N . LEU A 1 424 ? 57.613 -10.098 -15.829 1.00 9.28 ? 424 LEU A N 1 ATOM 3219 C CA . LEU A 1 424 ? 58.764 -10.546 -15.048 1.00 9.10 ? 424 LEU A CA 1 ATOM 3220 C C . LEU A 1 424 ? 59.907 -10.441 -16.030 1.00 9.81 ? 424 LEU A C 1 ATOM 3221 O O . LEU A 1 424 ? 59.913 -11.114 -17.074 1.00 9.46 ? 424 LEU A O 1 ATOM 3222 C CB . LEU A 1 424 ? 58.610 -11.995 -14.641 1.00 7.77 ? 424 LEU A CB 1 ATOM 3223 C CG . LEU A 1 424 ? 57.342 -12.377 -13.881 1.00 10.25 ? 424 LEU A CG 1 ATOM 3224 C CD1 . LEU A 1 424 ? 57.324 -13.917 -13.585 1.00 6.57 ? 424 LEU A CD1 1 ATOM 3225 C CD2 . LEU A 1 424 ? 57.239 -11.561 -12.602 1.00 9.15 ? 424 LEU A CD2 1 ATOM 3226 N N . SER A 1 425 ? 60.866 -9.582 -15.717 1.00 9.70 ? 425 SER A N 1 ATOM 3227 C CA . SER A 1 425 ? 61.935 -9.327 -16.657 1.00 9.72 ? 425 SER A CA 1 ATOM 3228 C C . SER A 1 425 ? 63.281 -9.287 -15.941 1.00 10.39 ? 425 SER A C 1 ATOM 3229 O O . SER A 1 425 ? 63.631 -10.198 -15.251 1.00 10.11 ? 425 SER A O 1 ATOM 3230 C CB . SER A 1 425 ? 61.663 -8.028 -17.427 1.00 8.76 ? 425 SER A CB 1 ATOM 3231 O OG . SER A 1 425 ? 62.596 -7.931 -18.491 1.00 8.86 ? 425 SER A OG 1 ATOM 3232 N N . HIS A 1 426 ? 64.001 -8.196 -16.064 1.00 11.73 ? 426 HIS A N 1 ATOM 3233 C CA . HIS A 1 426 ? 65.352 -8.169 -15.543 1.00 14.00 ? 426 HIS A CA 1 ATOM 3234 C C . HIS A 1 426 ? 65.520 -8.195 -14.004 1.00 14.01 ? 426 HIS A C 1 ATOM 3235 O O . HIS A 1 426 ? 66.342 -8.961 -13.511 1.00 13.71 ? 426 HIS A O 1 ATOM 3236 C CB . HIS A 1 426 ? 66.146 -7.026 -16.184 1.00 14.46 ? 426 HIS A CB 1 ATOM 3237 C CG . HIS A 1 426 ? 67.607 -7.147 -15.967 1.00 16.14 ? 426 HIS A CG 1 ATOM 3238 N ND1 . HIS A 1 426 ? 68.379 -8.070 -16.634 1.00 17.99 ? 426 HIS A ND1 1 ATOM 3239 C CD2 . HIS A 1 426 ? 68.434 -6.506 -15.102 1.00 18.31 ? 426 HIS A CD2 1 ATOM 3240 C CE1 . HIS A 1 426 ? 69.626 -7.984 -16.201 1.00 20.06 ? 426 HIS A CE1 1 ATOM 3241 N NE2 . HIS A 1 426 ? 69.684 -7.040 -15.273 1.00 18.53 ? 426 HIS A NE2 1 ATOM 3242 N N . SER A 1 427 ? 64.781 -7.399 -13.248 1.00 14.55 ? 427 SER A N 1 ATOM 3243 C CA . SER A 1 427 ? 64.984 -7.445 -11.792 1.00 17.37 ? 427 SER A CA 1 ATOM 3244 C C . SER A 1 427 ? 64.584 -8.768 -11.224 1.00 17.80 ? 427 SER A C 1 ATOM 3245 O O . SER A 1 427 ? 63.459 -9.199 -11.424 1.00 17.79 ? 427 SER A O 1 ATOM 3246 C CB . SER A 1 427 ? 64.182 -6.396 -11.015 1.00 16.80 ? 427 SER A CB 1 ATOM 3247 O OG . SER A 1 427 ? 64.344 -5.155 -11.614 1.00 21.69 ? 427 SER A OG 1 ATOM 3248 N N . ALA A 1 428 ? 65.487 -9.347 -10.450 1.00 19.16 ? 428 ALA A N 1 ATOM 3249 C CA . ALA A 1 428 ? 65.313 -10.650 -9.854 1.00 21.03 ? 428 ALA A CA 1 ATOM 3250 C C . ALA A 1 428 ? 66.488 -10.930 -8.928 1.00 22.73 ? 428 ALA A C 1 ATOM 3251 O O . ALA A 1 428 ? 67.551 -10.302 -9.017 1.00 22.77 ? 428 ALA A O 1 ATOM 3252 C CB . ALA A 1 428 ? 65.273 -11.706 -10.938 1.00 21.36 ? 428 ALA A CB 1 ATOM 3253 N N . ASN A 1 429 ? 66.285 -11.856 -8.013 1.00 24.40 ? 429 ASN A N 1 ATOM 3254 C CA . ASN A 1 429 ? 67.392 -12.361 -7.197 1.00 25.89 ? 429 ASN A CA 1 ATOM 3255 C C . ASN A 1 429 ? 67.165 -13.885 -7.058 1.00 26.06 ? 429 ASN A C 1 ATOM 3256 O O . ASN A 1 429 ? 66.325 -14.441 -7.790 1.00 26.07 ? 429 ASN A O 1 ATOM 3257 C CB . ASN A 1 429 ? 67.585 -11.556 -5.885 1.00 25.93 ? 429 ASN A CB 1 ATOM 3258 C CG . ASN A 1 429 ? 66.455 -11.721 -4.902 1.00 28.31 ? 429 ASN A CG 1 ATOM 3259 O OD1 . ASN A 1 429 ? 65.564 -12.542 -5.080 1.00 26.57 ? 429 ASN A OD1 1 ATOM 3260 N ND2 . ASN A 1 429 ? 66.519 -10.947 -3.827 1.00 33.77 ? 429 ASN A ND2 1 ATOM 3261 N N . GLY A 1 430 ? 67.875 -14.576 -6.164 1.00 25.73 ? 430 GLY A N 1 ATOM 3262 C CA . GLY A 1 430 ? 67.755 -16.030 -6.114 1.00 23.72 ? 430 GLY A CA 1 ATOM 3263 C C . GLY A 1 430 ? 66.449 -16.621 -5.572 1.00 22.69 ? 430 GLY A C 1 ATOM 3264 O O . GLY A 1 430 ? 66.208 -17.850 -5.675 1.00 22.00 ? 430 GLY A O 1 ATOM 3265 N N . SER A 1 431 ? 65.612 -15.759 -5.003 1.00 20.44 ? 431 SER A N 1 ATOM 3266 C CA . SER A 1 431 ? 64.345 -16.186 -4.447 1.00 19.27 ? 431 SER A CA 1 ATOM 3267 C C . SER A 1 431 ? 63.107 -15.345 -4.863 1.00 17.06 ? 431 SER A C 1 ATOM 3268 O O . SER A 1 431 ? 61.990 -15.742 -4.595 1.00 16.16 ? 431 SER A O 1 ATOM 3269 C CB . SER A 1 431 ? 64.446 -16.199 -2.931 1.00 19.30 ? 431 SER A CB 1 ATOM 3270 O OG . SER A 1 431 ? 64.444 -14.860 -2.500 1.00 21.65 ? 431 SER A OG 1 ATOM 3271 N N . VAL A 1 432 ? 63.299 -14.222 -5.538 1.00 15.14 ? 432 VAL A N 1 ATOM 3272 C CA . VAL A 1 432 ? 62.172 -13.391 -5.952 1.00 14.27 ? 432 VAL A CA 1 ATOM 3273 C C . VAL A 1 432 ? 62.377 -12.844 -7.367 1.00 13.63 ? 432 VAL A C 1 ATOM 3274 O O . VAL A 1 432 ? 63.445 -12.345 -7.658 1.00 13.12 ? 432 VAL A O 1 ATOM 3275 C CB . VAL A 1 432 ? 61.999 -12.176 -5.034 1.00 13.93 ? 432 VAL A CB 1 ATOM 3276 C CG1 . VAL A 1 432 ? 60.879 -11.328 -5.535 1.00 14.71 ? 432 VAL A CG1 1 ATOM 3277 C CG2 . VAL A 1 432 ? 61.660 -12.621 -3.606 1.00 16.86 ? 432 VAL A CG2 1 ATOM 3278 N N . TRP A 1 433 ? 61.359 -12.947 -8.229 1.00 12.13 ? 433 TRP A N 1 ATOM 3279 C CA . TRP A 1 433 ? 61.414 -12.420 -9.589 1.00 11.01 ? 433 TRP A CA 1 ATOM 3280 C C . TRP A 1 433 ? 60.412 -11.250 -9.535 1.00 10.98 ? 433 TRP A C 1 ATOM 3281 O O . TRP A 1 433 ? 59.238 -11.442 -9.264 1.00 10.56 ? 433 TRP A O 1 ATOM 3282 C CB . TRP A 1 433 ? 60.940 -13.514 -10.568 1.00 10.92 ? 433 TRP A CB 1 ATOM 3283 C CG . TRP A 1 433 ? 61.337 -13.301 -12.012 1.00 11.12 ? 433 TRP A CG 1 ATOM 3284 C CD1 . TRP A 1 433 ? 61.846 -12.161 -12.576 1.00 10.50 ? 433 TRP A CD1 1 ATOM 3285 C CD2 . TRP A 1 433 ? 61.278 -14.274 -13.059 1.00 12.16 ? 433 TRP A CD2 1 ATOM 3286 N NE1 . TRP A 1 433 ? 62.111 -12.368 -13.910 1.00 10.49 ? 433 TRP A NE1 1 ATOM 3287 C CE2 . TRP A 1 433 ? 61.776 -13.663 -14.232 1.00 11.29 ? 433 TRP A CE2 1 ATOM 3288 C CE3 . TRP A 1 433 ? 60.877 -15.619 -13.120 1.00 12.47 ? 433 TRP A CE3 1 ATOM 3289 C CZ2 . TRP A 1 433 ? 61.871 -14.342 -15.459 1.00 9.75 ? 433 TRP A CZ2 1 ATOM 3290 C CZ3 . TRP A 1 433 ? 60.987 -16.301 -14.352 1.00 13.61 ? 433 TRP A CZ3 1 ATOM 3291 C CH2 . TRP A 1 433 ? 61.477 -15.653 -15.494 1.00 10.36 ? 433 TRP A CH2 1 ATOM 3292 N N . GLU A 1 434 ? 60.853 -10.037 -9.762 1.00 10.62 ? 434 GLU A N 1 ATOM 3293 C CA . GLU A 1 434 ? 59.977 -8.897 -9.533 1.00 11.76 ? 434 GLU A CA 1 ATOM 3294 C C . GLU A 1 434 ? 59.000 -8.552 -10.669 1.00 11.24 ? 434 GLU A C 1 ATOM 3295 O O . GLU A 1 434 ? 59.363 -8.540 -11.828 1.00 9.37 ? 434 GLU A O 1 ATOM 3296 C CB . GLU A 1 434 ? 60.792 -7.655 -9.185 1.00 12.85 ? 434 GLU A CB 1 ATOM 3297 C CG . GLU A 1 434 ? 61.684 -7.792 -7.937 1.00 19.36 ? 434 GLU A CG 1 ATOM 3298 C CD . GLU A 1 434 ? 62.250 -6.434 -7.478 1.00 24.77 ? 434 GLU A CD 1 ATOM 3299 O OE1 . GLU A 1 434 ? 62.345 -6.175 -6.262 1.00 29.21 ? 434 GLU A OE1 1 ATOM 3300 O OE2 . GLU A 1 434 ? 62.559 -5.595 -8.330 1.00 26.40 ? 434 GLU A OE2 1 ATOM 3301 N N . ASP A 1 435 ? 57.755 -8.286 -10.290 1.00 10.21 ? 435 ASP A N 1 ATOM 3302 C CA . ASP A 1 435 ? 56.744 -7.813 -11.222 1.00 10.29 ? 435 ASP A CA 1 ATOM 3303 C C . ASP A 1 435 ? 57.235 -6.445 -11.644 1.00 10.11 ? 435 ASP A C 1 ATOM 3304 O O . ASP A 1 435 ? 57.404 -5.573 -10.831 1.00 10.31 ? 435 ASP A O 1 ATOM 3305 C CB . ASP A 1 435 ? 55.417 -7.706 -10.454 1.00 10.33 ? 435 ASP A CB 1 ATOM 3306 C CG . ASP A 1 435 ? 54.250 -7.278 -11.306 1.00 9.40 ? 435 ASP A CG 1 ATOM 3307 O OD1 . ASP A 1 435 ? 54.368 -7.087 -12.532 1.00 10.69 ? 435 ASP A OD1 1 ATOM 3308 O OD2 . ASP A 1 435 ? 53.150 -7.078 -10.789 1.00 9.55 ? 435 ASP A OD2 1 ATOM 3309 N N . VAL A 1 436 ? 57.502 -6.247 -12.919 1.00 10.58 ? 436 VAL A N 1 ATOM 3310 C CA . VAL A 1 436 ? 57.859 -4.887 -13.349 1.00 9.97 ? 436 VAL A CA 1 ATOM 3311 C C . VAL A 1 436 ? 56.699 -3.934 -12.950 1.00 10.60 ? 436 VAL A C 1 ATOM 3312 O O . VAL A 1 436 ? 56.909 -2.778 -12.651 1.00 10.40 ? 436 VAL A O 1 ATOM 3313 C CB . VAL A 1 436 ? 58.131 -4.838 -14.878 1.00 10.16 ? 436 VAL A CB 1 ATOM 3314 C CG1 . VAL A 1 436 ? 58.182 -3.417 -15.387 1.00 7.94 ? 436 VAL A CG1 1 ATOM 3315 C CG2 . VAL A 1 436 ? 59.447 -5.611 -15.228 1.00 6.26 ? 436 VAL A CG2 1 ATOM 3316 N N . TYR A 1 437 ? 55.478 -4.439 -12.906 1.00 10.06 ? 437 TYR A N 1 ATOM 3317 C CA . TYR A 1 437 ? 54.349 -3.590 -12.517 1.00 9.96 ? 437 TYR A CA 1 ATOM 3318 C C . TYR A 1 437 ? 54.108 -3.484 -11.007 1.00 10.38 ? 437 TYR A C 1 ATOM 3319 O O . TYR A 1 437 ? 53.130 -2.859 -10.596 1.00 10.29 ? 437 TYR A O 1 ATOM 3320 C CB . TYR A 1 437 ? 53.088 -3.969 -13.286 1.00 9.50 ? 437 TYR A CB 1 ATOM 3321 C CG . TYR A 1 437 ? 53.189 -3.493 -14.737 1.00 10.10 ? 437 TYR A CG 1 ATOM 3322 C CD1 . TYR A 1 437 ? 53.875 -4.240 -15.678 1.00 9.84 ? 437 TYR A CD1 1 ATOM 3323 C CD2 . TYR A 1 437 ? 52.633 -2.271 -15.140 1.00 9.58 ? 437 TYR A CD2 1 ATOM 3324 C CE1 . TYR A 1 437 ? 53.986 -3.807 -17.030 1.00 12.60 ? 437 TYR A CE1 1 ATOM 3325 C CE2 . TYR A 1 437 ? 52.738 -1.828 -16.442 1.00 11.06 ? 437 TYR A CE2 1 ATOM 3326 C CZ . TYR A 1 437 ? 53.409 -2.600 -17.391 1.00 12.91 ? 437 TYR A CZ 1 ATOM 3327 O OH . TYR A 1 437 ? 53.537 -2.155 -18.680 1.00 13.68 ? 437 TYR A OH 1 ATOM 3328 N N . ARG A 1 438 ? 55.008 -4.077 -10.203 1.00 10.58 ? 438 ARG A N 1 ATOM 3329 C CA . ARG A 1 438 ? 55.028 -3.921 -8.713 1.00 10.48 ? 438 ARG A CA 1 ATOM 3330 C C . ARG A 1 438 ? 53.830 -4.399 -7.932 1.00 10.16 ? 438 ARG A C 1 ATOM 3331 O O . ARG A 1 438 ? 53.544 -3.893 -6.832 1.00 10.63 ? 438 ARG A O 1 ATOM 3332 C CB . ARG A 1 438 ? 55.301 -2.457 -8.295 1.00 10.19 ? 438 ARG A CB 1 ATOM 3333 C CG . ARG A 1 438 ? 56.574 -1.834 -8.965 1.00 11.86 ? 438 ARG A CG 1 ATOM 3334 C CD . ARG A 1 438 ? 56.752 -0.324 -8.731 1.00 12.02 ? 438 ARG A CD 1 ATOM 3335 N NE . ARG A 1 438 ? 56.926 -0.004 -7.303 1.00 12.52 ? 438 ARG A NE 1 ATOM 3336 C CZ . ARG A 1 438 ? 57.040 1.234 -6.831 1.00 13.76 ? 438 ARG A CZ 1 ATOM 3337 N NH1 . ARG A 1 438 ? 57.225 1.437 -5.535 1.00 10.99 ? 438 ARG A NH1 1 ATOM 3338 N NH2 . ARG A 1 438 ? 56.991 2.275 -7.671 1.00 15.84 ? 438 ARG A NH2 1 ATOM 3339 N N . CYS A 1 439 ? 53.134 -5.379 -8.455 1.00 9.30 ? 439 CYS A N 1 ATOM 3340 C CA . CYS A 1 439 ? 51.953 -5.854 -7.768 1.00 9.01 ? 439 CYS A CA 1 ATOM 3341 C C . CYS A 1 439 ? 52.094 -7.283 -7.273 1.00 9.30 ? 439 CYS A C 1 ATOM 3342 O O . CYS A 1 439 ? 51.855 -7.537 -6.110 1.00 10.30 ? 439 CYS A O 1 ATOM 3343 C CB . CYS A 1 439 ? 50.765 -5.760 -8.689 1.00 8.69 ? 439 CYS A CB 1 ATOM 3344 S SG . CYS A 1 439 ? 50.197 -4.077 -8.974 1.00 10.93 ? 439 CYS A SG 1 ATOM 3345 N N . VAL A 1 440 ? 52.490 -8.213 -8.134 1.00 8.29 ? 440 VAL A N 1 ATOM 3346 C CA . VAL A 1 440 ? 52.572 -9.595 -7.744 1.00 8.29 ? 440 VAL A CA 1 ATOM 3347 C C . VAL A 1 440 ? 53.872 -10.223 -8.208 1.00 9.18 ? 440 VAL A C 1 ATOM 3348 O O . VAL A 1 440 ? 54.019 -10.508 -9.380 1.00 8.39 ? 440 VAL A O 1 ATOM 3349 C CB . VAL A 1 440 ? 51.425 -10.409 -8.382 1.00 9.42 ? 440 VAL A CB 1 ATOM 3350 C CG1 . VAL A 1 440 ? 51.547 -11.859 -7.977 1.00 8.34 ? 440 VAL A CG1 1 ATOM 3351 C CG2 . VAL A 1 440 ? 50.023 -9.837 -7.961 1.00 8.10 ? 440 VAL A CG2 1 ATOM 3352 N N . ASP A 1 441 ? 54.822 -10.416 -7.290 1.00 9.15 ? 441 ASP A N 1 ATOM 3353 C CA . ASP A 1 441 ? 56.087 -11.033 -7.642 1.00 10.07 ? 441 ASP A CA 1 ATOM 3354 C C . ASP A 1 441 ? 55.937 -12.529 -7.773 1.00 9.94 ? 441 ASP A C 1 ATOM 3355 O O . ASP A 1 441 ? 55.005 -13.089 -7.223 1.00 10.46 ? 441 ASP A O 1 ATOM 3356 C CB . ASP A 1 441 ? 57.138 -10.773 -6.556 1.00 9.65 ? 441 ASP A CB 1 ATOM 3357 C CG . ASP A 1 441 ? 57.464 -9.298 -6.394 1.00 11.76 ? 441 ASP A CG 1 ATOM 3358 O OD1 . ASP A 1 441 ? 57.270 -8.518 -7.352 1.00 11.69 ? 441 ASP A OD1 1 ATOM 3359 O OD2 . ASP A 1 441 ? 57.924 -8.836 -5.337 1.00 12.72 ? 441 ASP A OD2 1 ATOM 3360 N N . ALA A 1 442 ? 56.891 -13.170 -8.452 1.00 10.09 ? 442 ALA A N 1 ATOM 3361 C CA . ALA A 1 442 ? 56.970 -14.629 -8.493 1.00 11.56 ? 442 ALA A CA 1 ATOM 3362 C C . ALA A 1 442 ? 58.014 -15.131 -7.503 1.00 12.40 ? 442 ALA A C 1 ATOM 3363 O O . ALA A 1 442 ? 59.022 -14.449 -7.291 1.00 12.24 ? 442 ALA A O 1 ATOM 3364 C CB . ALA A 1 442 ? 57.299 -15.138 -9.932 1.00 10.81 ? 442 ALA A CB 1 ATOM 3365 N N . ASN A 1 443 ? 57.767 -16.306 -6.898 1.00 13.54 ? 443 ASN A N 1 ATOM 3366 C CA . ASN A 1 443 ? 58.726 -16.958 -5.986 1.00 14.81 ? 443 ASN A CA 1 ATOM 3367 C C . ASN A 1 443 ? 59.686 -17.879 -6.770 1.00 13.93 ? 443 ASN A C 1 ATOM 3368 O O . ASN A 1 443 ? 59.257 -18.647 -7.652 1.00 12.13 ? 443 ASN A O 1 ATOM 3369 C CB . ASN A 1 443 ? 58.007 -17.779 -4.900 1.00 16.19 ? 443 ASN A CB 1 ATOM 3370 C CG . ASN A 1 443 ? 56.875 -17.008 -4.263 1.00 22.79 ? 443 ASN A CG 1 ATOM 3371 O OD1 . ASN A 1 443 ? 57.114 -16.043 -3.526 1.00 28.38 ? 443 ASN A OD1 1 ATOM 3372 N ND2 . ASN A 1 443 ? 55.635 -17.401 -4.567 1.00 27.02 ? 443 ASN A ND2 1 ATOM 3373 N N . VAL A 1 444 ? 60.969 -17.815 -6.426 1.00 12.21 ? 444 VAL A N 1 ATOM 3374 C CA . VAL A 1 444 ? 61.981 -18.477 -7.233 1.00 12.00 ? 444 VAL A CA 1 ATOM 3375 C C . VAL A 1 444 ? 62.781 -19.472 -6.438 1.00 11.75 ? 444 VAL A C 1 ATOM 3376 O O . VAL A 1 444 ? 62.963 -19.280 -5.248 1.00 11.67 ? 444 VAL A O 1 ATOM 3377 C CB . VAL A 1 444 ? 62.972 -17.383 -7.729 1.00 12.37 ? 444 VAL A CB 1 ATOM 3378 C CG1 . VAL A 1 444 ? 64.197 -17.950 -8.344 1.00 8.44 ? 444 VAL A CG1 1 ATOM 3379 C CG2 . VAL A 1 444 ? 62.247 -16.407 -8.656 1.00 13.79 ? 444 VAL A CG2 1 ATOM 3380 N N . ALA A 1 445 ? 63.247 -20.527 -7.092 1.00 11.07 ? 445 ALA A N 1 ATOM 3381 C CA . ALA A 1 445 ? 64.233 -21.396 -6.500 1.00 11.99 ? 445 ALA A CA 1 ATOM 3382 C C . ALA A 1 445 ? 65.193 -21.987 -7.554 1.00 12.19 ? 445 ALA A C 1 ATOM 3383 O O . ALA A 1 445 ? 64.833 -22.159 -8.721 1.00 13.01 ? 445 ALA A O 1 ATOM 3384 C CB . ALA A 1 445 ? 63.580 -22.519 -5.671 1.00 12.30 ? 445 ALA A CB 1 ATOM 3385 N N . ASN A 1 446 ? 66.403 -22.291 -7.109 1.00 11.60 ? 446 ASN A N 1 ATOM 3386 C CA . ASN A 1 446 ? 67.431 -22.899 -7.937 1.00 12.16 ? 446 ASN A CA 1 ATOM 3387 C C . ASN A 1 446 ? 67.651 -22.192 -9.255 1.00 11.81 ? 446 ASN A C 1 ATOM 3388 O O . ASN A 1 446 ? 67.627 -22.799 -10.348 1.00 11.23 ? 446 ASN A O 1 ATOM 3389 C CB . ASN A 1 446 ? 67.204 -24.406 -8.062 1.00 12.19 ? 446 ASN A CB 1 ATOM 3390 C CG . ASN A 1 446 ? 67.850 -25.138 -6.910 1.00 15.55 ? 446 ASN A CG 1 ATOM 3391 O OD1 . ASN A 1 446 ? 68.824 -24.633 -6.356 1.00 15.94 ? 446 ASN A OD1 1 ATOM 3392 N ND2 . ASN A 1 446 ? 67.296 -26.284 -6.507 1.00 13.63 ? 446 ASN A ND2 1 ATOM 3393 N N . ALA A 1 447 ? 67.874 -20.885 -9.132 1.00 11.68 ? 447 ALA A N 1 ATOM 3394 C CA . ALA A 1 447 ? 68.031 -20.046 -10.295 1.00 12.15 ? 447 ALA A CA 1 ATOM 3395 C C . ALA A 1 447 ? 69.251 -19.165 -10.236 1.00 13.12 ? 447 ALA A C 1 ATOM 3396 O O . ALA A 1 447 ? 69.715 -18.794 -9.163 1.00 13.36 ? 447 ALA A O 1 ATOM 3397 C CB . ALA A 1 447 ? 66.840 -19.199 -10.472 1.00 10.89 ? 447 ALA A CB 1 ATOM 3398 N N . GLU A 1 448 ? 69.737 -18.825 -11.422 1.00 13.17 ? 448 GLU A N 1 ATOM 3399 C CA . GLU A 1 448 ? 70.785 -17.856 -11.553 1.00 15.07 ? 448 GLU A CA 1 ATOM 3400 C C . GLU A 1 448 ? 70.329 -16.833 -12.601 1.00 14.26 ? 448 GLU A C 1 ATOM 3401 O O . GLU A 1 448 ? 69.669 -17.165 -13.602 1.00 13.10 ? 448 GLU A O 1 ATOM 3402 C CB . GLU A 1 448 ? 72.122 -18.493 -11.923 1.00 15.13 ? 448 GLU A CB 1 ATOM 3403 C CG . GLU A 1 448 ? 72.284 -18.752 -13.405 1.00 20.72 ? 448 GLU A CG 1 ATOM 3404 C CD . GLU A 1 448 ? 73.505 -19.634 -13.740 1.00 28.39 ? 448 GLU A CD 1 ATOM 3405 O OE1 . GLU A 1 448 ? 73.510 -20.858 -13.348 1.00 30.38 ? 448 GLU A OE1 1 ATOM 3406 O OE2 . GLU A 1 448 ? 74.436 -19.112 -14.401 1.00 25.56 ? 448 GLU A OE2 1 ATOM 3407 N N . ARG A 1 449 ? 70.700 -15.588 -12.359 1.00 13.50 ? 449 ARG A N 1 ATOM 3408 C CA . ARG A 1 449 ? 70.304 -14.500 -13.224 1.00 14.28 ? 449 ARG A CA 1 ATOM 3409 C C . ARG A 1 449 ? 70.960 -14.483 -14.600 1.00 13.30 ? 449 ARG A C 1 ATOM 3410 O O . ARG A 1 449 ? 72.142 -14.747 -14.713 1.00 13.48 ? 449 ARG A O 1 ATOM 3411 C CB . ARG A 1 449 ? 70.617 -13.185 -12.521 1.00 14.34 ? 449 ARG A CB 1 ATOM 3412 C CG . ARG A 1 449 ? 69.957 -13.044 -11.127 1.00 19.45 ? 449 ARG A CG 1 ATOM 3413 C CD . ARG A 1 449 ? 70.147 -11.646 -10.536 1.00 22.82 ? 449 ARG A CD 1 ATOM 3414 N NE . ARG A 1 449 ? 69.417 -10.663 -11.337 1.00 24.68 ? 449 ARG A NE 1 ATOM 3415 C CZ . ARG A 1 449 ? 69.579 -9.347 -11.241 1.00 25.94 ? 449 ARG A CZ 1 ATOM 3416 N NH1 . ARG A 1 449 ? 70.445 -8.831 -10.377 1.00 24.89 ? 449 ARG A NH1 1 ATOM 3417 N NH2 . ARG A 1 449 ? 68.841 -8.540 -11.981 1.00 24.49 ? 449 ARG A NH2 1 ATOM 3418 N N . VAL A 1 450 ? 70.174 -14.146 -15.619 1.00 11.62 ? 450 VAL A N 1 ATOM 3419 C CA . VAL A 1 450 ? 70.673 -13.850 -16.953 1.00 11.52 ? 450 VAL A CA 1 ATOM 3420 C C . VAL A 1 450 ? 69.913 -12.599 -17.368 1.00 12.20 ? 450 VAL A C 1 ATOM 3421 O O . VAL A 1 450 ? 68.945 -12.175 -16.690 1.00 12.71 ? 450 VAL A O 1 ATOM 3422 C CB . VAL A 1 450 ? 70.308 -14.911 -17.976 1.00 12.76 ? 450 VAL A CB 1 ATOM 3423 C CG1 . VAL A 1 450 ? 71.014 -16.273 -17.653 1.00 10.82 ? 450 VAL A CG1 1 ATOM 3424 C CG2 . VAL A 1 450 ? 68.758 -15.022 -18.109 1.00 10.05 ? 450 VAL A CG2 1 ATOM 3425 N N . PRO A 1 451 ? 70.356 -11.968 -18.440 1.00 11.65 ? 451 PRO A N 1 ATOM 3426 C CA . PRO A 1 451 ? 69.696 -10.751 -18.928 1.00 11.91 ? 451 PRO A CA 1 ATOM 3427 C C . PRO A 1 451 ? 68.194 -10.949 -19.105 1.00 11.69 ? 451 PRO A C 1 ATOM 3428 O O . PRO A 1 451 ? 67.819 -11.848 -19.833 1.00 11.04 ? 451 PRO A O 1 ATOM 3429 C CB . PRO A 1 451 ? 70.391 -10.505 -20.286 1.00 12.21 ? 451 PRO A CB 1 ATOM 3430 C CG . PRO A 1 451 ? 71.840 -10.987 -19.990 1.00 12.81 ? 451 PRO A CG 1 ATOM 3431 C CD . PRO A 1 451 ? 71.561 -12.312 -19.225 1.00 12.52 ? 451 PRO A CD 1 ATOM 3432 N N . ASN A 1 452 ? 67.371 -10.160 -18.412 1.00 11.51 ? 452 ASN A N 1 ATOM 3433 C CA . ASN A 1 452 ? 65.916 -10.216 -18.563 1.00 11.20 ? 452 ASN A CA 1 ATOM 3434 C C . ASN A 1 452 ? 65.215 -11.470 -18.013 1.00 11.75 ? 452 ASN A C 1 ATOM 3435 O O . ASN A 1 452 ? 64.026 -11.706 -18.272 1.00 12.83 ? 452 ASN A O 1 ATOM 3436 C CB . ASN A 1 452 ? 65.550 -9.968 -20.022 1.00 10.77 ? 452 ASN A CB 1 ATOM 3437 C CG . ASN A 1 452 ? 65.817 -8.535 -20.438 1.00 10.03 ? 452 ASN A CG 1 ATOM 3438 O OD1 . ASN A 1 452 ? 65.559 -7.595 -19.668 1.00 8.01 ? 452 ASN A OD1 1 ATOM 3439 N ND2 . ASN A 1 452 ? 66.325 -8.345 -21.659 1.00 8.70 ? 452 ASN A ND2 1 ATOM 3440 N N . GLY A 1 453 ? 65.928 -12.244 -17.196 1.00 12.23 ? 453 GLY A N 1 ATOM 3441 C CA . GLY A 1 453 ? 65.322 -13.410 -16.602 1.00 11.61 ? 453 GLY A CA 1 ATOM 3442 C C . GLY A 1 453 ? 66.219 -14.352 -15.859 1.00 11.94 ? 453 GLY A C 1 ATOM 3443 O O . GLY A 1 453 ? 67.219 -13.948 -15.245 1.00 13.33 ? 453 GLY A O 1 ATOM 3444 N N . LEU A 1 454 ? 65.862 -15.628 -15.921 1.00 11.17 ? 454 LEU A N 1 ATOM 3445 C CA . LEU A 1 454 ? 66.478 -16.628 -15.050 1.00 11.73 ? 454 LEU A CA 1 ATOM 3446 C C . LEU A 1 454 ? 66.765 -17.940 -15.755 1.00 11.20 ? 454 LEU A C 1 ATOM 3447 O O . LEU A 1 454 ? 66.026 -18.363 -16.616 1.00 10.88 ? 454 LEU A O 1 ATOM 3448 C CB . LEU A 1 454 ? 65.513 -16.909 -13.887 1.00 10.88 ? 454 LEU A CB 1 ATOM 3449 C CG . LEU A 1 454 ? 65.536 -16.220 -12.502 1.00 14.29 ? 454 LEU A CG 1 ATOM 3450 C CD1 . LEU A 1 454 ? 66.637 -15.119 -12.186 1.00 10.24 ? 454 LEU A CD1 1 ATOM 3451 C CD2 . LEU A 1 454 ? 64.130 -15.859 -12.004 1.00 13.58 ? 454 LEU A CD2 1 ATOM 3452 N N . LYS A 1 455 ? 67.883 -18.551 -15.388 1.00 11.35 ? 455 LYS A N 1 ATOM 3453 C CA . LYS A 1 455 ? 68.262 -19.868 -15.853 1.00 11.83 ? 455 LYS A CA 1 ATOM 3454 C C . LYS A 1 455 ? 68.101 -20.812 -14.638 1.00 12.16 ? 455 LYS A C 1 ATOM 3455 O O . LYS A 1 455 ? 68.622 -20.544 -13.557 1.00 10.42 ? 455 LYS A O 1 ATOM 3456 C CB . LYS A 1 455 ? 69.720 -19.834 -16.261 1.00 12.01 ? 455 LYS A CB 1 ATOM 3457 C CG . LYS A 1 455 ? 70.341 -21.164 -16.518 1.00 14.30 ? 455 LYS A CG 1 ATOM 3458 C CD . LYS A 1 455 ? 71.743 -20.984 -17.117 1.00 17.82 ? 455 LYS A CD 1 ATOM 3459 C CE . LYS A 1 455 ? 72.341 -22.343 -17.374 1.00 21.57 ? 455 LYS A CE 1 ATOM 3460 N NZ . LYS A 1 455 ? 73.267 -22.423 -18.559 1.00 23.87 ? 455 LYS A NZ 1 ATOM 3461 N N . PHE A 1 456 ? 67.386 -21.910 -14.820 1.00 12.49 ? 456 PHE A N 1 ATOM 3462 C CA . PHE A 1 456 ? 67.142 -22.809 -13.711 1.00 13.97 ? 456 PHE A CA 1 ATOM 3463 C C . PHE A 1 456 ? 68.043 -24.003 -13.744 1.00 14.98 ? 456 PHE A C 1 ATOM 3464 O O . PHE A 1 456 ? 68.265 -24.582 -14.812 1.00 15.98 ? 456 PHE A O 1 ATOM 3465 C CB . PHE A 1 456 ? 65.670 -23.220 -13.744 1.00 12.81 ? 456 PHE A CB 1 ATOM 3466 C CG . PHE A 1 456 ? 64.759 -22.050 -13.775 1.00 12.98 ? 456 PHE A CG 1 ATOM 3467 C CD1 . PHE A 1 456 ? 64.004 -21.743 -14.928 1.00 14.48 ? 456 PHE A CD1 1 ATOM 3468 C CD2 . PHE A 1 456 ? 64.663 -21.221 -12.665 1.00 12.41 ? 456 PHE A CD2 1 ATOM 3469 C CE1 . PHE A 1 456 ? 63.151 -20.660 -14.949 1.00 12.31 ? 456 PHE A CE1 1 ATOM 3470 C CE2 . PHE A 1 456 ? 63.835 -20.115 -12.681 1.00 13.00 ? 456 PHE A CE2 1 ATOM 3471 C CZ . PHE A 1 456 ? 63.057 -19.837 -13.811 1.00 14.18 ? 456 PHE A CZ 1 ATOM 3472 N N . ASN A 1 457 ? 68.573 -24.372 -12.587 1.00 15.88 ? 457 ASN A N 1 ATOM 3473 C CA . ASN A 1 457 ? 69.405 -25.547 -12.516 1.00 18.93 ? 457 ASN A CA 1 ATOM 3474 C C . ASN A 1 457 ? 69.346 -26.093 -11.112 1.00 19.28 ? 457 ASN A C 1 ATOM 3475 O O . ASN A 1 457 ? 69.844 -25.461 -10.196 1.00 22.14 ? 457 ASN A O 1 ATOM 3476 C CB . ASN A 1 457 ? 70.848 -25.180 -12.891 1.00 19.91 ? 457 ASN A CB 1 ATOM 3477 C CG . ASN A 1 457 ? 71.820 -26.361 -12.732 1.00 24.28 ? 457 ASN A CG 1 ATOM 3478 O OD1 . ASN A 1 457 ? 71.767 -27.104 -11.734 1.00 24.40 ? 457 ASN A OD1 1 ATOM 3479 N ND2 . ASN A 1 457 ? 72.730 -26.520 -13.711 1.00 25.61 ? 457 ASN A ND2 1 ATOM 3480 N N . GLY A 1 458 ? 68.697 -27.226 -10.919 1.00 18.50 ? 458 GLY A N 1 ATOM 3481 C CA . GLY A 1 458 ? 68.589 -27.831 -9.616 1.00 16.01 ? 458 GLY A CA 1 ATOM 3482 C C . GLY A 1 458 ? 67.158 -28.320 -9.413 1.00 15.16 ? 458 GLY A C 1 ATOM 3483 O O . GLY A 1 458 ? 66.270 -27.907 -10.106 1.00 12.68 ? 458 GLY A O 1 ATOM 3484 N N . VAL A 1 459 ? 66.972 -29.211 -8.447 1.00 15.04 ? 459 VAL A N 1 ATOM 3485 C CA . VAL A 1 459 ? 65.689 -29.788 -8.140 1.00 15.24 ? 459 VAL A CA 1 ATOM 3486 C C . VAL A 1 459 ? 64.727 -28.657 -7.819 1.00 14.92 ? 459 VAL A C 1 ATOM 3487 O O . VAL A 1 459 ? 65.034 -27.806 -6.970 1.00 13.41 ? 459 VAL A O 1 ATOM 3488 C CB . VAL A 1 459 ? 65.740 -30.649 -6.817 1.00 16.62 ? 459 VAL A CB 1 ATOM 3489 C CG1 . VAL A 1 459 ? 64.316 -31.087 -6.416 1.00 18.87 ? 459 VAL A CG1 1 ATOM 3490 C CG2 . VAL A 1 459 ? 66.621 -31.828 -6.948 1.00 16.05 ? 459 VAL A CG2 1 ATOM 3491 N N . GLY A 1 460 ? 63.554 -28.650 -8.458 1.00 14.01 ? 460 GLY A N 1 ATOM 3492 C CA . GLY A 1 460 ? 62.590 -27.591 -8.167 1.00 13.65 ? 460 GLY A CA 1 ATOM 3493 C C . GLY A 1 460 ? 63.017 -26.242 -8.773 1.00 13.73 ? 460 GLY A C 1 ATOM 3494 O O . GLY A 1 460 ? 62.464 -25.193 -8.403 1.00 13.82 ? 460 GLY A O 1 ATOM 3495 N N . GLY A 1 461 ? 63.978 -26.254 -9.704 1.00 11.91 ? 461 GLY A N 1 ATOM 3496 C CA . GLY A 1 461 ? 64.372 -25.018 -10.355 1.00 11.85 ? 461 GLY A CA 1 ATOM 3497 C C . GLY A 1 461 ? 63.205 -24.465 -11.160 1.00 12.63 ? 461 GLY A C 1 ATOM 3498 O O . GLY A 1 461 ? 62.671 -25.139 -12.064 1.00 12.81 ? 461 GLY A O 1 ATOM 3499 N N . GLY A 1 462 ? 62.828 -23.217 -10.879 1.00 12.87 ? 462 GLY A N 1 ATOM 3500 C CA . GLY A 1 462 ? 61.640 -22.638 -11.483 1.00 11.74 ? 462 GLY A CA 1 ATOM 3501 C C . GLY A 1 462 ? 61.093 -21.462 -10.680 1.00 12.56 ? 462 GLY A C 1 ATOM 3502 O O . GLY A 1 462 ? 61.701 -21.042 -9.672 1.00 12.25 ? 462 GLY A O 1 ATOM 3503 N N . ALA A 1 463 ? 59.967 -20.900 -11.149 1.00 11.35 ? 463 ALA A N 1 ATOM 3504 C CA . ALA A 1 463 ? 59.335 -19.786 -10.476 1.00 10.30 ? 463 ALA A CA 1 ATOM 3505 C C . ALA A 1 463 ? 57.836 -20.009 -10.396 1.00 10.12 ? 463 ALA A C 1 ATOM 3506 O O . ALA A 1 463 ? 57.265 -20.510 -11.343 1.00 10.65 ? 463 ALA A O 1 ATOM 3507 C CB . ALA A 1 463 ? 59.618 -18.505 -11.232 1.00 9.65 ? 463 ALA A CB 1 ATOM 3508 N N . VAL A 1 464 ? 57.210 -19.583 -9.289 1.00 10.05 ? 464 VAL A N 1 ATOM 3509 C CA . VAL A 1 464 ? 55.776 -19.715 -9.034 1.00 8.48 ? 464 VAL A CA 1 ATOM 3510 C C . VAL A 1 464 ? 55.189 -18.321 -9.032 1.00 9.46 ? 464 VAL A C 1 ATOM 3511 O O . VAL A 1 464 ? 55.642 -17.431 -8.280 1.00 10.01 ? 464 VAL A O 1 ATOM 3512 C CB . VAL A 1 464 ? 55.553 -20.341 -7.657 1.00 9.24 ? 464 VAL A CB 1 ATOM 3513 C CG1 . VAL A 1 464 ? 54.060 -20.290 -7.235 1.00 6.02 ? 464 VAL A CG1 1 ATOM 3514 C CG2 . VAL A 1 464 ? 56.111 -21.802 -7.580 1.00 7.94 ? 464 VAL A CG2 1 ATOM 3515 N N . TRP A 1 465 ? 54.215 -18.078 -9.902 1.00 8.95 ? 465 TRP A N 1 ATOM 3516 C CA . TRP A 1 465 ? 53.590 -16.776 -9.963 1.00 8.94 ? 465 TRP A CA 1 ATOM 3517 C C . TRP A 1 465 ? 52.231 -17.100 -9.426 1.00 8.95 ? 465 TRP A C 1 ATOM 3518 O O . TRP A 1 465 ? 51.415 -17.637 -10.119 1.00 9.24 ? 465 TRP A O 1 ATOM 3519 C CB . TRP A 1 465 ? 53.509 -16.272 -11.419 1.00 9.59 ? 465 TRP A CB 1 ATOM 3520 C CG . TRP A 1 465 ? 53.522 -14.765 -11.603 1.00 9.82 ? 465 TRP A CG 1 ATOM 3521 C CD1 . TRP A 1 465 ? 53.570 -13.773 -10.621 1.00 10.61 ? 465 TRP A CD1 1 ATOM 3522 C CD2 . TRP A 1 465 ? 53.510 -14.078 -12.844 1.00 7.83 ? 465 TRP A CD2 1 ATOM 3523 N NE1 . TRP A 1 465 ? 53.595 -12.521 -11.208 1.00 8.55 ? 465 TRP A NE1 1 ATOM 3524 C CE2 . TRP A 1 465 ? 53.563 -12.688 -12.573 1.00 8.83 ? 465 TRP A CE2 1 ATOM 3525 C CE3 . TRP A 1 465 ? 53.503 -14.493 -14.169 1.00 10.00 ? 465 TRP A CE3 1 ATOM 3526 C CZ2 . TRP A 1 465 ? 53.570 -11.741 -13.575 1.00 7.25 ? 465 TRP A CZ2 1 ATOM 3527 C CZ3 . TRP A 1 465 ? 53.511 -13.521 -15.172 1.00 9.96 ? 465 TRP A CZ3 1 ATOM 3528 C CH2 . TRP A 1 465 ? 53.559 -12.178 -14.860 1.00 8.99 ? 465 TRP A CH2 1 ATOM 3529 N N . PRO A 1 466 ? 51.985 -16.755 -8.169 1.00 9.37 ? 466 PRO A N 1 ATOM 3530 C CA . PRO A 1 466 ? 50.771 -17.189 -7.477 1.00 9.33 ? 466 PRO A CA 1 ATOM 3531 C C . PRO A 1 466 ? 49.485 -16.663 -8.090 1.00 9.99 ? 466 PRO A C 1 ATOM 3532 O O . PRO A 1 466 ? 49.400 -15.463 -8.460 1.00 8.49 ? 466 PRO A O 1 ATOM 3533 C CB . PRO A 1 466 ? 50.877 -16.556 -6.074 1.00 9.61 ? 466 PRO A CB 1 ATOM 3534 C CG . PRO A 1 466 ? 52.198 -15.823 -6.025 1.00 11.24 ? 466 PRO A CG 1 ATOM 3535 C CD . PRO A 1 466 ? 52.842 -15.869 -7.375 1.00 8.78 ? 466 PRO A CD 1 ATOM 3536 N N . VAL A 1 467 ? 48.486 -17.549 -8.133 1.00 9.82 ? 467 VAL A N 1 ATOM 3537 C CA . VAL A 1 467 ? 47.146 -17.173 -8.529 1.00 10.23 ? 467 VAL A CA 1 ATOM 3538 C C . VAL A 1 467 ? 46.263 -17.412 -7.301 1.00 11.19 ? 467 VAL A C 1 ATOM 3539 O O . VAL A 1 467 ? 46.167 -16.530 -6.432 1.00 11.78 ? 467 VAL A O 1 ATOM 3540 C CB . VAL A 1 467 ? 46.710 -17.884 -9.844 1.00 10.37 ? 467 VAL A CB 1 ATOM 3541 C CG1 . VAL A 1 467 ? 45.264 -17.481 -10.230 1.00 9.30 ? 467 VAL A CG1 1 ATOM 3542 C CG2 . VAL A 1 467 ? 47.704 -17.481 -11.009 1.00 7.97 ? 467 VAL A CG2 1 ATOM 3543 N N . ALA A 1 468 ? 45.625 -18.572 -7.171 1.00 11.82 ? 468 ALA A N 1 ATOM 3544 C CA . ALA A 1 468 ? 44.878 -18.830 -5.906 1.00 11.91 ? 468 ALA A CA 1 ATOM 3545 C C . ALA A 1 468 ? 45.859 -18.798 -4.715 1.00 12.22 ? 468 ALA A C 1 ATOM 3546 O O . ALA A 1 468 ? 45.484 -18.491 -3.576 1.00 12.20 ? 468 ALA A O 1 ATOM 3547 C CB . ALA A 1 468 ? 44.176 -20.177 -5.928 1.00 11.37 ? 468 ALA A CB 1 ATOM 3548 N N . ARG A 1 469 ? 47.112 -19.118 -4.987 1.00 12.37 ? 469 ARG A N 1 ATOM 3549 C CA . ARG A 1 469 ? 48.126 -19.069 -3.932 1.00 13.72 ? 469 ARG A CA 1 ATOM 3550 C C . ARG A 1 469 ? 48.355 -17.637 -3.413 1.00 13.20 ? 469 ARG A C 1 ATOM 3551 O O . ARG A 1 469 ? 48.991 -17.480 -2.400 1.00 13.72 ? 469 ARG A O 1 ATOM 3552 C CB . ARG A 1 469 ? 49.456 -19.720 -4.352 1.00 13.66 ? 469 ARG A CB 1 ATOM 3553 C CG . ARG A 1 469 ? 49.396 -21.260 -4.489 1.00 16.04 ? 469 ARG A CG 1 ATOM 3554 C CD . ARG A 1 469 ? 50.751 -21.967 -4.836 1.00 21.26 ? 469 ARG A CD 1 ATOM 3555 N NE . ARG A 1 469 ? 50.564 -23.393 -5.209 1.00 24.05 ? 469 ARG A NE 1 ATOM 3556 C CZ . ARG A 1 469 ? 51.559 -24.207 -5.611 1.00 25.27 ? 469 ARG A CZ 1 ATOM 3557 N NH1 . ARG A 1 469 ? 52.809 -23.749 -5.701 1.00 22.90 ? 469 ARG A NH1 1 ATOM 3558 N NH2 . ARG A 1 469 ? 51.309 -25.475 -5.935 1.00 24.97 ? 469 ARG A NH2 1 ATOM 3559 N N . GLN A 1 470 ? 47.829 -16.610 -4.075 1.00 11.90 ? 470 GLN A N 1 ATOM 3560 C CA . GLN A 1 470 ? 47.863 -15.287 -3.452 1.00 12.13 ? 470 GLN A CA 1 ATOM 3561 C C . GLN A 1 470 ? 47.111 -15.329 -2.089 1.00 12.38 ? 470 GLN A C 1 ATOM 3562 O O . GLN A 1 470 ? 47.359 -14.507 -1.198 1.00 12.40 ? 470 GLN A O 1 ATOM 3563 C CB . GLN A 1 470 ? 47.251 -14.205 -4.372 1.00 11.26 ? 470 GLN A CB 1 ATOM 3564 C CG . GLN A 1 470 ? 48.126 -13.942 -5.609 1.00 10.92 ? 470 GLN A CG 1 ATOM 3565 C CD . GLN A 1 470 ? 47.589 -12.841 -6.509 1.00 9.54 ? 470 GLN A CD 1 ATOM 3566 O OE1 . GLN A 1 470 ? 46.864 -11.915 -6.051 1.00 10.92 ? 470 GLN A OE1 1 ATOM 3567 N NE2 . GLN A 1 470 ? 47.896 -12.956 -7.803 1.00 6.66 ? 470 GLN A NE2 1 ATOM 3568 N N . GLY A 1 471 ? 46.177 -16.266 -1.921 1.00 11.67 ? 471 GLY A N 1 ATOM 3569 C CA . GLY A 1 471 ? 45.509 -16.364 -0.633 1.00 11.15 ? 471 GLY A CA 1 ATOM 3570 C C . GLY A 1 471 ? 44.136 -15.711 -0.605 1.00 10.92 ? 471 GLY A C 1 ATOM 3571 O O . GLY A 1 471 ? 43.268 -16.042 -1.413 1.00 11.80 ? 471 GLY A O 1 ATOM 3572 N N . GLN A 1 472 ? 43.952 -14.762 0.304 1.00 10.15 ? 472 GLN A N 1 ATOM 3573 C CA . GLN A 1 472 ? 42.663 -14.119 0.544 1.00 10.48 ? 472 GLN A CA 1 ATOM 3574 C C . GLN A 1 472 ? 42.258 -13.227 -0.595 1.00 10.18 ? 472 GLN A C 1 ATOM 3575 O O . GLN A 1 472 ? 41.165 -13.343 -1.123 1.00 9.83 ? 472 GLN A O 1 ATOM 3576 C CB . GLN A 1 472 ? 42.706 -13.331 1.882 1.00 10.94 ? 472 GLN A CB 1 ATOM 3577 C CG . GLN A 1 472 ? 41.508 -12.387 2.196 1.00 12.56 ? 472 GLN A CG 1 ATOM 3578 C CD . GLN A 1 472 ? 41.449 -11.919 3.674 1.00 13.75 ? 472 GLN A CD 1 ATOM 3579 O OE1 . GLN A 1 472 ? 42.357 -12.172 4.436 1.00 11.65 ? 472 GLN A OE1 1 ATOM 3580 N NE2 . GLN A 1 472 ? 40.366 -11.256 4.056 1.00 12.16 ? 472 GLN A NE2 1 ATOM 3581 N N . THR A 1 473 ? 43.139 -12.301 -0.957 1.00 9.80 ? 473 THR A N 1 ATOM 3582 C CA . THR A 1 473 ? 42.877 -11.395 -2.055 1.00 10.05 ? 473 THR A CA 1 ATOM 3583 C C . THR A 1 473 ? 43.492 -11.993 -3.307 1.00 10.30 ? 473 THR A C 1 ATOM 3584 O O . THR A 1 473 ? 44.686 -12.172 -3.325 1.00 10.37 ? 473 THR A O 1 ATOM 3585 C CB . THR A 1 473 ? 43.514 -10.055 -1.700 1.00 10.32 ? 473 THR A CB 1 ATOM 3586 O OG1 . THR A 1 473 ? 42.858 -9.534 -0.528 1.00 9.13 ? 473 THR A OG1 1 ATOM 3587 C CG2 . THR A 1 473 ? 43.268 -9.023 -2.800 1.00 8.81 ? 473 THR A CG2 1 ATOM 3588 N N . ARG A 1 474 ? 42.670 -12.327 -4.308 1.00 9.92 ? 474 ARG A N 1 ATOM 3589 C CA . ARG A 1 474 ? 43.109 -13.000 -5.540 1.00 10.71 ? 474 ARG A CA 1 ATOM 3590 C C . ARG A 1 474 ? 43.129 -12.118 -6.798 1.00 10.12 ? 474 ARG A C 1 ATOM 3591 O O . ARG A 1 474 ? 42.214 -12.103 -7.590 1.00 10.45 ? 474 ARG A O 1 ATOM 3592 C CB . ARG A 1 474 ? 42.236 -14.226 -5.784 1.00 10.90 ? 474 ARG A CB 1 ATOM 3593 C CG . ARG A 1 474 ? 42.333 -15.155 -4.591 1.00 13.21 ? 474 ARG A CG 1 ATOM 3594 C CD . ARG A 1 474 ? 41.639 -16.472 -4.697 1.00 11.92 ? 474 ARG A CD 1 ATOM 3595 N NE . ARG A 1 474 ? 42.076 -17.296 -3.585 1.00 16.22 ? 474 ARG A NE 1 ATOM 3596 C CZ . ARG A 1 474 ? 41.851 -18.601 -3.477 1.00 19.61 ? 474 ARG A CZ 1 ATOM 3597 N NH1 . ARG A 1 474 ? 41.212 -19.244 -4.457 1.00 19.44 ? 474 ARG A NH1 1 ATOM 3598 N NH2 . ARG A 1 474 ? 42.286 -19.255 -2.400 1.00 17.38 ? 474 ARG A NH2 1 ATOM 3599 N N . ARG A 1 475 ? 44.231 -11.442 -6.981 1.00 10.09 ? 475 ARG A N 1 ATOM 3600 C CA . ARG A 1 475 ? 44.348 -10.385 -7.967 1.00 9.61 ? 475 ARG A CA 1 ATOM 3601 C C . ARG A 1 475 ? 44.461 -10.902 -9.359 1.00 9.12 ? 475 ARG A C 1 ATOM 3602 O O . ARG A 1 475 ? 44.167 -10.158 -10.301 1.00 9.93 ? 475 ARG A O 1 ATOM 3603 C CB . ARG A 1 475 ? 45.531 -9.476 -7.571 1.00 9.87 ? 475 ARG A CB 1 ATOM 3604 C CG . ARG A 1 475 ? 45.207 -8.733 -6.231 1.00 8.45 ? 475 ARG A CG 1 ATOM 3605 C CD . ARG A 1 475 ? 46.332 -7.834 -5.753 1.00 11.69 ? 475 ARG A CD 1 ATOM 3606 N NE . ARG A 1 475 ? 47.433 -8.576 -5.135 1.00 12.48 ? 475 ARG A NE 1 ATOM 3607 C CZ . ARG A 1 475 ? 48.675 -8.107 -5.015 1.00 15.50 ? 475 ARG A CZ 1 ATOM 3608 N NH1 . ARG A 1 475 ? 49.616 -8.837 -4.428 1.00 14.07 ? 475 ARG A NH1 1 ATOM 3609 N NH2 . ARG A 1 475 ? 48.985 -6.888 -5.461 1.00 14.39 ? 475 ARG A NH2 1 ATOM 3610 N N . TYR A 1 476 ? 44.867 -12.164 -9.495 1.00 7.77 ? 476 TYR A N 1 ATOM 3611 C CA . TYR A 1 476 ? 44.952 -12.789 -10.798 1.00 8.35 ? 476 TYR A CA 1 ATOM 3612 C C . TYR A 1 476 ? 43.739 -13.709 -11.011 1.00 8.98 ? 476 TYR A C 1 ATOM 3613 O O . TYR A 1 476 ? 43.716 -14.573 -11.913 1.00 9.55 ? 476 TYR A O 1 ATOM 3614 C CB . TYR A 1 476 ? 46.268 -13.560 -10.959 1.00 7.79 ? 476 TYR A CB 1 ATOM 3615 C CG . TYR A 1 476 ? 47.522 -12.691 -11.158 1.00 9.35 ? 476 TYR A CG 1 ATOM 3616 C CD1 . TYR A 1 476 ? 48.767 -13.272 -11.288 1.00 7.67 ? 476 TYR A CD1 1 ATOM 3617 C CD2 . TYR A 1 476 ? 47.453 -11.284 -11.180 1.00 6.93 ? 476 TYR A CD2 1 ATOM 3618 C CE1 . TYR A 1 476 ? 49.898 -12.497 -11.461 1.00 10.30 ? 476 TYR A CE1 1 ATOM 3619 C CE2 . TYR A 1 476 ? 48.571 -10.527 -11.334 1.00 6.96 ? 476 TYR A CE2 1 ATOM 3620 C CZ . TYR A 1 476 ? 49.791 -11.132 -11.487 1.00 8.68 ? 476 TYR A CZ 1 ATOM 3621 O OH . TYR A 1 476 ? 50.933 -10.378 -11.678 1.00 11.01 ? 476 TYR A OH 1 ATOM 3622 N N . GLN A 1 477 ? 42.730 -13.538 -10.171 1.00 8.87 ? 477 GLN A N 1 ATOM 3623 C CA . GLN A 1 477 ? 41.466 -14.283 -10.342 1.00 8.53 ? 477 GLN A CA 1 ATOM 3624 C C . GLN A 1 477 ? 40.956 -14.239 -11.773 1.00 7.70 ? 477 GLN A C 1 ATOM 3625 O O . GLN A 1 477 ? 40.295 -15.165 -12.204 1.00 8.12 ? 477 GLN A O 1 ATOM 3626 C CB . GLN A 1 477 ? 40.366 -13.727 -9.392 1.00 9.33 ? 477 GLN A CB 1 ATOM 3627 C CG . GLN A 1 477 ? 38.951 -14.338 -9.526 1.00 8.23 ? 477 GLN A CG 1 ATOM 3628 C CD . GLN A 1 477 ? 38.879 -15.819 -9.156 1.00 11.35 ? 477 GLN A CD 1 ATOM 3629 O OE1 . GLN A 1 477 ? 39.761 -16.333 -8.447 1.00 10.18 ? 477 GLN A OE1 1 ATOM 3630 N NE2 . GLN A 1 477 ? 37.805 -16.506 -9.603 1.00 8.84 ? 477 GLN A NE2 1 ATOM 3631 N N . PHE A 1 478 ? 41.262 -13.181 -12.522 1.00 7.57 ? 478 PHE A N 1 ATOM 3632 C CA . PHE A 1 478 ? 40.758 -13.069 -13.896 1.00 7.27 ? 478 PHE A CA 1 ATOM 3633 C C . PHE A 1 478 ? 41.176 -14.252 -14.746 1.00 7.30 ? 478 PHE A C 1 ATOM 3634 O O . PHE A 1 478 ? 40.463 -14.607 -15.688 1.00 8.45 ? 478 PHE A O 1 ATOM 3635 C CB . PHE A 1 478 ? 41.261 -11.792 -14.624 1.00 7.83 ? 478 PHE A CB 1 ATOM 3636 C CG . PHE A 1 478 ? 42.763 -11.769 -14.817 1.00 7.18 ? 478 PHE A CG 1 ATOM 3637 C CD1 . PHE A 1 478 ? 43.576 -11.119 -13.896 1.00 8.79 ? 478 PHE A CD1 1 ATOM 3638 C CD2 . PHE A 1 478 ? 43.364 -12.465 -15.874 1.00 9.76 ? 478 PHE A CD2 1 ATOM 3639 C CE1 . PHE A 1 478 ? 44.962 -11.120 -14.041 1.00 9.56 ? 478 PHE A CE1 1 ATOM 3640 C CE2 . PHE A 1 478 ? 44.745 -12.491 -16.037 1.00 10.39 ? 478 PHE A CE2 1 ATOM 3641 C CZ . PHE A 1 478 ? 45.554 -11.817 -15.106 1.00 11.58 ? 478 PHE A CZ 1 ATOM 3642 N N . ALA A 1 479 ? 42.336 -14.838 -14.474 1.00 7.24 ? 479 ALA A N 1 ATOM 3643 C CA . ALA A 1 479 ? 42.879 -15.890 -15.360 1.00 7.15 ? 479 ALA A CA 1 ATOM 3644 C C . ALA A 1 479 ? 42.025 -17.147 -15.470 1.00 7.96 ? 479 ALA A C 1 ATOM 3645 O O . ALA A 1 479 ? 42.239 -17.984 -16.364 1.00 6.99 ? 479 ALA A O 1 ATOM 3646 C CB . ALA A 1 479 ? 44.305 -16.285 -14.941 1.00 6.50 ? 479 ALA A CB 1 ATOM 3647 N N . ASN A 1 480 ? 41.130 -17.332 -14.507 1.00 8.85 ? 480 ASN A N 1 ATOM 3648 C CA . ASN A 1 480 ? 40.284 -18.515 -14.475 1.00 9.84 ? 480 ASN A CA 1 ATOM 3649 C C . ASN A 1 480 ? 39.244 -18.426 -15.588 1.00 10.13 ? 480 ASN A C 1 ATOM 3650 O O . ASN A 1 480 ? 38.628 -19.415 -16.016 1.00 10.44 ? 480 ASN A O 1 ATOM 3651 C CB . ASN A 1 480 ? 39.644 -18.663 -13.083 1.00 9.40 ? 480 ASN A CB 1 ATOM 3652 C CG . ASN A 1 480 ? 40.639 -19.196 -12.060 1.00 10.54 ? 480 ASN A CG 1 ATOM 3653 O OD1 . ASN A 1 480 ? 41.296 -20.198 -12.304 1.00 13.87 ? 480 ASN A OD1 1 ATOM 3654 N ND2 . ASN A 1 480 ? 40.766 -18.523 -10.926 1.00 9.64 ? 480 ASN A ND2 1 ATOM 3655 N N . TYR A 1 481 ? 39.103 -17.221 -16.094 1.00 10.28 ? 481 TYR A N 1 ATOM 3656 C CA . TYR A 1 481 ? 38.167 -16.948 -17.176 1.00 10.24 ? 481 TYR A CA 1 ATOM 3657 C C . TYR A 1 481 ? 38.902 -16.757 -18.502 1.00 10.48 ? 481 TYR A C 1 ATOM 3658 O O . TYR A 1 481 ? 38.440 -17.230 -19.508 1.00 11.40 ? 481 TYR A O 1 ATOM 3659 C CB . TYR A 1 481 ? 37.465 -15.663 -16.838 1.00 8.76 ? 481 TYR A CB 1 ATOM 3660 C CG . TYR A 1 481 ? 36.476 -15.194 -17.844 1.00 10.31 ? 481 TYR A CG 1 ATOM 3661 C CD1 . TYR A 1 481 ? 35.317 -15.953 -18.135 1.00 9.05 ? 481 TYR A CD1 1 ATOM 3662 C CD2 . TYR A 1 481 ? 36.646 -13.994 -18.468 1.00 7.99 ? 481 TYR A CD2 1 ATOM 3663 C CE1 . TYR A 1 481 ? 34.399 -15.501 -19.043 1.00 11.51 ? 481 TYR A CE1 1 ATOM 3664 C CE2 . TYR A 1 481 ? 35.705 -13.516 -19.367 1.00 12.84 ? 481 TYR A CE2 1 ATOM 3665 C CZ . TYR A 1 481 ? 34.590 -14.279 -19.657 1.00 13.42 ? 481 TYR A CZ 1 ATOM 3666 O OH . TYR A 1 481 ? 33.640 -13.785 -20.544 1.00 17.15 ? 481 TYR A OH 1 ATOM 3667 N N . ARG A 1 482 ? 40.039 -16.054 -18.506 1.00 10.38 ? 482 ARG A N 1 ATOM 3668 C CA . ARG A 1 482 ? 40.816 -15.871 -19.737 1.00 10.20 ? 482 ARG A CA 1 ATOM 3669 C C . ARG A 1 482 ? 42.228 -15.365 -19.416 1.00 10.51 ? 482 ARG A C 1 ATOM 3670 O O . ARG A 1 482 ? 42.390 -14.636 -18.433 1.00 10.60 ? 482 ARG A O 1 ATOM 3671 C CB . ARG A 1 482 ? 40.138 -14.870 -20.676 1.00 10.28 ? 482 ARG A CB 1 ATOM 3672 C CG . ARG A 1 482 ? 39.880 -13.475 -20.108 1.00 9.92 ? 482 ARG A CG 1 ATOM 3673 C CD . ARG A 1 482 ? 39.024 -12.607 -21.030 1.00 13.33 ? 482 ARG A CD 1 ATOM 3674 N NE . ARG A 1 482 ? 38.886 -11.202 -20.650 1.00 13.49 ? 482 ARG A NE 1 ATOM 3675 C CZ . ARG A 1 482 ? 37.904 -10.422 -21.120 1.00 17.54 ? 482 ARG A CZ 1 ATOM 3676 N NH1 . ARG A 1 482 ? 37.009 -10.925 -21.976 1.00 16.46 ? 482 ARG A NH1 1 ATOM 3677 N NH2 . ARG A 1 482 ? 37.799 -9.163 -20.738 1.00 14.45 ? 482 ARG A NH2 1 ATOM 3678 N N . PHE A 1 483 ? 43.243 -15.769 -20.189 1.00 9.50 ? 483 PHE A N 1 ATOM 3679 C CA . PHE A 1 483 ? 44.567 -15.146 -20.056 1.00 9.37 ? 483 PHE A CA 1 ATOM 3680 C C . PHE A 1 483 ? 45.411 -15.348 -21.274 1.00 9.25 ? 483 PHE A C 1 ATOM 3681 O O . PHE A 1 483 ? 45.089 -16.165 -22.134 1.00 9.33 ? 483 PHE A O 1 ATOM 3682 C CB . PHE A 1 483 ? 45.371 -15.649 -18.827 1.00 8.57 ? 483 PHE A CB 1 ATOM 3683 C CG . PHE A 1 483 ? 45.733 -17.132 -18.874 1.00 10.21 ? 483 PHE A CG 1 ATOM 3684 C CD1 . PHE A 1 483 ? 46.904 -17.562 -19.462 1.00 10.68 ? 483 PHE A CD1 1 ATOM 3685 C CD2 . PHE A 1 483 ? 44.895 -18.087 -18.285 1.00 8.93 ? 483 PHE A CD2 1 ATOM 3686 C CE1 . PHE A 1 483 ? 47.238 -18.933 -19.450 1.00 10.11 ? 483 PHE A CE1 1 ATOM 3687 C CE2 . PHE A 1 483 ? 45.186 -19.434 -18.309 1.00 8.08 ? 483 PHE A CE2 1 ATOM 3688 C CZ . PHE A 1 483 ? 46.374 -19.859 -18.882 1.00 9.90 ? 483 PHE A CZ 1 ATOM 3689 N N . THR A 1 484 ? 46.496 -14.577 -21.325 1.00 8.80 ? 484 THR A N 1 ATOM 3690 C CA . THR A 1 484 ? 47.559 -14.815 -22.256 1.00 8.35 ? 484 THR A CA 1 ATOM 3691 C C . THR A 1 484 ? 48.850 -14.777 -21.441 1.00 8.38 ? 484 THR A C 1 ATOM 3692 O O . THR A 1 484 ? 49.107 -13.835 -20.731 1.00 8.90 ? 484 THR A O 1 ATOM 3693 C CB . THR A 1 484 ? 47.586 -13.797 -23.386 1.00 8.39 ? 484 THR A CB 1 ATOM 3694 O OG1 . THR A 1 484 ? 46.364 -13.882 -24.127 1.00 7.22 ? 484 THR A OG1 1 ATOM 3695 C CG2 . THR A 1 484 ? 48.622 -14.195 -24.416 1.00 6.95 ? 484 THR A CG2 1 ATOM 3696 N N . LEU A 1 485 ? 49.650 -15.826 -21.536 1.00 7.85 ? 485 LEU A N 1 ATOM 3697 C CA . LEU A 1 485 ? 50.878 -15.881 -20.793 1.00 8.22 ? 485 LEU A CA 1 ATOM 3698 C C . LEU A 1 485 ? 51.972 -16.041 -21.878 1.00 7.98 ? 485 LEU A C 1 ATOM 3699 O O . LEU A 1 485 ? 51.892 -16.952 -22.711 1.00 6.86 ? 485 LEU A O 1 ATOM 3700 C CB . LEU A 1 485 ? 50.869 -17.069 -19.837 1.00 7.38 ? 485 LEU A CB 1 ATOM 3701 C CG . LEU A 1 485 ? 52.147 -17.246 -18.983 1.00 9.99 ? 485 LEU A CG 1 ATOM 3702 C CD1 . LEU A 1 485 ? 52.334 -16.135 -17.991 1.00 5.95 ? 485 LEU A CD1 1 ATOM 3703 C CD2 . LEU A 1 485 ? 52.195 -18.637 -18.227 1.00 7.57 ? 485 LEU A CD2 1 ATOM 3704 N N . VAL A 1 486 ? 52.960 -15.145 -21.847 1.00 7.14 ? 486 VAL A N 1 ATOM 3705 C CA . VAL A 1 486 ? 54.006 -15.101 -22.852 1.00 6.80 ? 486 VAL A CA 1 ATOM 3706 C C . VAL A 1 486 ? 55.373 -15.269 -22.246 1.00 7.57 ? 486 VAL A C 1 ATOM 3707 O O . VAL A 1 486 ? 55.606 -14.801 -21.152 1.00 8.87 ? 486 VAL A O 1 ATOM 3708 C CB . VAL A 1 486 ? 53.949 -13.734 -23.493 1.00 7.44 ? 486 VAL A CB 1 ATOM 3709 C CG1 . VAL A 1 486 ? 54.943 -13.606 -24.697 1.00 5.14 ? 486 VAL A CG1 1 ATOM 3710 C CG2 . VAL A 1 486 ? 52.498 -13.451 -23.897 1.00 6.28 ? 486 VAL A CG2 1 ATOM 3711 N N . ALA A 1 487 ? 56.289 -15.915 -22.953 1.00 7.27 ? 487 ALA A N 1 ATOM 3712 C CA . ALA A 1 487 ? 57.663 -16.031 -22.473 1.00 8.26 ? 487 ALA A CA 1 ATOM 3713 C C . ALA A 1 487 ? 58.630 -16.416 -23.591 1.00 9.24 ? 487 ALA A C 1 ATOM 3714 O O . ALA A 1 487 ? 58.221 -17.011 -24.628 1.00 9.77 ? 487 ALA A O 1 ATOM 3715 C CB . ALA A 1 487 ? 57.777 -17.064 -21.312 1.00 7.97 ? 487 ALA A CB 1 ATOM 3716 N N . THR A 1 488 ? 59.896 -16.053 -23.383 1.00 9.23 ? 488 THR A N 1 ATOM 3717 C CA . THR A 1 488 ? 60.975 -16.376 -24.305 1.00 9.50 ? 488 THR A CA 1 ATOM 3718 C C . THR A 1 488 ? 61.793 -17.422 -23.576 1.00 10.11 ? 488 THR A C 1 ATOM 3719 O O . THR A 1 488 ? 62.153 -17.203 -22.402 1.00 9.39 ? 488 THR A O 1 ATOM 3720 C CB . THR A 1 488 ? 61.831 -15.130 -24.591 1.00 9.70 ? 488 THR A CB 1 ATOM 3721 O OG1 . THR A 1 488 ? 61.084 -14.217 -25.428 1.00 11.38 ? 488 THR A OG1 1 ATOM 3722 C CG2 . THR A 1 488 ? 63.052 -15.500 -25.460 1.00 7.59 ? 488 THR A CG2 1 ATOM 3723 N N . VAL A 1 489 ? 62.050 -18.559 -24.243 1.00 10.02 ? 489 VAL A N 1 ATOM 3724 C CA . VAL A 1 489 ? 62.760 -19.669 -23.631 1.00 9.32 ? 489 VAL A CA 1 ATOM 3725 C C . VAL A 1 489 ? 63.903 -20.275 -24.457 1.00 10.82 ? 489 VAL A C 1 ATOM 3726 O O . VAL A 1 489 ? 63.928 -20.172 -25.697 1.00 8.69 ? 489 VAL A O 1 ATOM 3727 C CB . VAL A 1 489 ? 61.806 -20.859 -23.400 1.00 10.19 ? 489 VAL A CB 1 ATOM 3728 C CG1 . VAL A 1 489 ? 60.562 -20.457 -22.629 1.00 6.86 ? 489 VAL A CG1 1 ATOM 3729 C CG2 . VAL A 1 489 ? 61.446 -21.570 -24.722 1.00 9.02 ? 489 VAL A CG2 1 ATOM 3730 N N . THR A 1 490 ? 64.862 -20.913 -23.766 1.00 10.79 ? 490 THR A N 1 ATOM 3731 C CA . THR A 1 490 ? 65.773 -21.828 -24.458 1.00 11.24 ? 490 THR A CA 1 ATOM 3732 C C . THR A 1 490 ? 65.734 -23.136 -23.673 1.00 10.99 ? 490 THR A C 1 ATOM 3733 O O . THR A 1 490 ? 65.559 -23.133 -22.466 1.00 10.75 ? 490 THR A O 1 ATOM 3734 C CB . THR A 1 490 ? 67.271 -21.350 -24.549 1.00 11.72 ? 490 THR A CB 1 ATOM 3735 O OG1 . THR A 1 490 ? 67.814 -21.150 -23.236 1.00 14.36 ? 490 THR A OG1 1 ATOM 3736 C CG2 . THR A 1 490 ? 67.437 -20.041 -25.232 1.00 10.06 ? 490 THR A CG2 1 ATOM 3737 N N . ILE A 1 491 ? 65.895 -24.262 -24.336 1.00 11.45 ? 491 ILE A N 1 ATOM 3738 C CA . ILE A 1 491 ? 66.053 -25.486 -23.568 1.00 11.63 ? 491 ILE A CA 1 ATOM 3739 C C . ILE A 1 491 ? 67.565 -25.660 -23.467 1.00 12.17 ? 491 ILE A C 1 ATOM 3740 O O . ILE A 1 491 ? 68.277 -25.630 -24.475 1.00 12.20 ? 491 ILE A O 1 ATOM 3741 C CB . ILE A 1 491 ? 65.327 -26.609 -24.222 1.00 11.31 ? 491 ILE A CB 1 ATOM 3742 C CG1 . ILE A 1 491 ? 63.829 -26.273 -24.266 1.00 13.90 ? 491 ILE A CG1 1 ATOM 3743 C CG2 . ILE A 1 491 ? 65.438 -27.878 -23.412 1.00 10.85 ? 491 ILE A CG2 1 ATOM 3744 C CD1 . ILE A 1 491 ? 63.115 -27.111 -25.261 1.00 17.67 ? 491 ILE A CD1 1 ATOM 3745 N N . ASP A 1 492 ? 68.065 -25.744 -22.244 1.00 12.54 ? 492 ASP A N 1 ATOM 3746 C CA . ASP A 1 492 ? 69.521 -25.797 -22.027 1.00 12.80 ? 492 ASP A CA 1 ATOM 3747 C C . ASP A 1 492 ? 70.119 -27.211 -22.014 1.00 13.41 ? 492 ASP A C 1 ATOM 3748 O O . ASP A 1 492 ? 71.251 -27.408 -22.438 1.00 13.19 ? 492 ASP A O 1 ATOM 3749 C CB . ASP A 1 492 ? 69.864 -25.088 -20.724 1.00 11.83 ? 492 ASP A CB 1 ATOM 3750 C CG . ASP A 1 492 ? 69.363 -23.660 -20.695 1.00 11.34 ? 492 ASP A CG 1 ATOM 3751 O OD1 . ASP A 1 492 ? 69.422 -23.016 -21.745 1.00 12.33 ? 492 ASP A OD1 1 ATOM 3752 O OD2 . ASP A 1 492 ? 68.884 -23.083 -19.691 1.00 10.77 ? 492 ASP A OD2 1 ATOM 3753 N N . GLU A 1 493 ? 69.364 -28.171 -21.485 1.00 14.26 ? 493 GLU A N 1 ATOM 3754 C CA . GLU A 1 493 ? 69.783 -29.589 -21.433 1.00 14.77 ? 493 GLU A CA 1 ATOM 3755 C C . GLU A 1 493 ? 68.568 -30.492 -21.672 1.00 14.74 ? 493 GLU A C 1 ATOM 3756 O O . GLU A 1 493 ? 67.459 -30.186 -21.214 1.00 13.81 ? 493 GLU A O 1 ATOM 3757 C CB . GLU A 1 493 ? 70.418 -29.931 -20.084 1.00 14.44 ? 493 GLU A CB 1 ATOM 3758 C CG . GLU A 1 493 ? 71.589 -29.017 -19.727 1.00 18.19 ? 493 GLU A CG 1 ATOM 3759 C CD . GLU A 1 493 ? 72.202 -29.324 -18.373 1.00 21.29 ? 493 GLU A CD 1 ATOM 3760 O OE1 . GLU A 1 493 ? 72.007 -28.533 -17.428 1.00 22.39 ? 493 GLU A OE1 1 ATOM 3761 O OE2 . GLU A 1 493 ? 72.875 -30.369 -18.247 1.00 25.24 ? 493 GLU A OE2 1 ATOM 3762 N N . LEU A 1 494 ? 68.788 -31.575 -22.414 1.00 14.77 ? 494 LEU A N 1 ATOM 3763 C CA . LEU A 1 494 ? 67.785 -32.579 -22.668 1.00 15.59 ? 494 LEU A CA 1 ATOM 3764 C C . LEU A 1 494 ? 67.284 -33.171 -21.370 1.00 14.84 ? 494 LEU A C 1 ATOM 3765 O O . LEU A 1 494 ? 68.062 -33.484 -20.471 1.00 16.18 ? 494 LEU A O 1 ATOM 3766 C CB . LEU A 1 494 ? 68.410 -33.723 -23.458 1.00 15.99 ? 494 LEU A CB 1 ATOM 3767 C CG . LEU A 1 494 ? 68.371 -33.960 -24.973 1.00 19.23 ? 494 LEU A CG 1 ATOM 3768 C CD1 . LEU A 1 494 ? 67.812 -32.818 -25.835 1.00 18.35 ? 494 LEU A CD1 1 ATOM 3769 C CD2 . LEU A 1 494 ? 69.742 -34.533 -25.512 1.00 19.65 ? 494 LEU A CD2 1 ATOM 3770 N N . PRO A 1 495 ? 65.983 -33.383 -21.290 1.00 14.18 ? 495 PRO A N 1 ATOM 3771 C CA . PRO A 1 495 ? 65.372 -33.991 -20.107 1.00 13.83 ? 495 PRO A CA 1 ATOM 3772 C C . PRO A 1 495 ? 65.444 -35.542 -20.158 1.00 14.38 ? 495 PRO A C 1 ATOM 3773 O O . PRO A 1 495 ? 65.619 -36.124 -21.226 1.00 13.69 ? 495 PRO A O 1 ATOM 3774 C CB . PRO A 1 495 ? 63.911 -33.566 -20.235 1.00 13.61 ? 495 PRO A CB 1 ATOM 3775 C CG . PRO A 1 495 ? 63.680 -33.504 -21.744 1.00 13.28 ? 495 PRO A CG 1 ATOM 3776 C CD . PRO A 1 495 ? 64.999 -33.078 -22.354 1.00 13.59 ? 495 PRO A CD 1 ATOM 3777 N N . LYS A 1 496 ? 65.275 -36.204 -19.022 1.00 14.44 ? 496 LYS A N 1 ATOM 3778 C CA . LYS A 1 496 ? 65.276 -37.664 -19.027 1.00 15.65 ? 496 LYS A CA 1 ATOM 3779 C C . LYS A 1 496 ? 64.121 -38.194 -19.850 1.00 14.79 ? 496 LYS A C 1 ATOM 3780 O O . LYS A 1 496 ? 64.306 -39.063 -20.695 1.00 14.24 ? 496 LYS A O 1 ATOM 3781 C CB . LYS A 1 496 ? 65.131 -38.238 -17.626 1.00 15.79 ? 496 LYS A CB 1 ATOM 3782 C CG . LYS A 1 496 ? 65.688 -39.664 -17.532 1.00 18.95 ? 496 LYS A CG 1 ATOM 3783 C CD . LYS A 1 496 ? 65.540 -40.147 -16.095 1.00 23.56 ? 496 LYS A CD 1 ATOM 3784 C CE . LYS A 1 496 ? 65.176 -41.625 -16.063 1.00 25.44 ? 496 LYS A CE 1 ATOM 3785 N NZ . LYS A 1 496 ? 66.429 -42.449 -16.128 1.00 28.67 ? 496 LYS A NZ 1 ATOM 3786 N N . GLY A 1 497 ? 62.933 -37.677 -19.579 1.00 13.35 ? 497 GLY A N 1 ATOM 3787 C CA . GLY A 1 497 ? 61.758 -38.062 -20.345 1.00 13.90 ? 497 GLY A CA 1 ATOM 3788 C C . GLY A 1 497 ? 61.040 -36.795 -20.763 1.00 14.46 ? 497 GLY A C 1 ATOM 3789 O O . GLY A 1 497 ? 61.421 -36.146 -21.753 1.00 13.96 ? 497 GLY A O 1 ATOM 3790 N N . THR A 1 498 ? 60.075 -36.399 -19.944 1.00 14.56 ? 498 THR A N 1 ATOM 3791 C CA . THR A 1 498 ? 59.327 -35.154 -20.126 1.00 16.28 ? 498 THR A CA 1 ATOM 3792 C C . THR A 1 498 ? 59.579 -34.180 -18.958 1.00 16.36 ? 498 THR A C 1 ATOM 3793 O O . THR A 1 498 ? 59.724 -34.615 -17.801 1.00 17.75 ? 498 THR A O 1 ATOM 3794 C CB . THR A 1 498 ? 57.855 -35.527 -20.211 1.00 17.07 ? 498 THR A CB 1 ATOM 3795 O OG1 . THR A 1 498 ? 57.633 -36.252 -21.448 1.00 18.14 ? 498 THR A OG1 1 ATOM 3796 C CG2 . THR A 1 498 ? 56.962 -34.292 -20.321 1.00 18.54 ? 498 THR A CG2 1 ATOM 3797 N N . SER A 1 499 ? 59.693 -32.883 -19.244 1.00 15.23 ? 499 SER A N 1 ATOM 3798 C CA . SER A 1 499 ? 59.869 -31.874 -18.194 1.00 13.91 ? 499 SER A CA 1 ATOM 3799 C C . SER A 1 499 ? 59.023 -30.627 -18.499 1.00 13.24 ? 499 SER A C 1 ATOM 3800 O O . SER A 1 499 ? 58.777 -30.317 -19.648 1.00 12.94 ? 499 SER A O 1 ATOM 3801 C CB . SER A 1 499 ? 61.352 -31.525 -18.024 1.00 13.87 ? 499 SER A CB 1 ATOM 3802 O OG . SER A 1 499 ? 61.617 -31.155 -16.673 1.00 18.39 ? 499 SER A OG 1 ATOM 3803 N N . PRO A 1 500 ? 58.546 -29.932 -17.465 1.00 13.31 ? 500 PRO A N 1 ATOM 3804 C CA . PRO A 1 500 ? 57.706 -28.742 -17.637 1.00 12.41 ? 500 PRO A CA 1 ATOM 3805 C C . PRO A 1 500 ? 58.498 -27.473 -17.955 1.00 11.86 ? 500 PRO A C 1 ATOM 3806 O O . PRO A 1 500 ? 59.637 -27.271 -17.533 1.00 11.18 ? 500 PRO A O 1 ATOM 3807 C CB . PRO A 1 500 ? 57.011 -28.581 -16.268 1.00 12.17 ? 500 PRO A CB 1 ATOM 3808 C CG . PRO A 1 500 ? 57.654 -29.564 -15.369 1.00 13.64 ? 500 PRO A CG 1 ATOM 3809 C CD . PRO A 1 500 ? 58.798 -30.221 -16.045 1.00 13.50 ? 500 PRO A CD 1 ATOM 3810 N N . LEU A 1 501 ? 57.850 -26.598 -18.690 1.00 10.71 ? 501 LEU A N 1 ATOM 3811 C CA . LEU A 1 501 ? 58.467 -25.378 -19.154 1.00 10.39 ? 501 LEU A CA 1 ATOM 3812 C C . LEU A 1 501 ? 57.629 -24.162 -18.730 1.00 9.86 ? 501 LEU A C 1 ATOM 3813 O O . LEU A 1 501 ? 58.140 -23.218 -18.152 1.00 10.05 ? 501 LEU A O 1 ATOM 3814 C CB . LEU A 1 501 ? 58.565 -25.450 -20.679 1.00 9.78 ? 501 LEU A CB 1 ATOM 3815 C CG . LEU A 1 501 ? 59.019 -24.180 -21.392 1.00 12.47 ? 501 LEU A CG 1 ATOM 3816 C CD1 . LEU A 1 501 ? 60.388 -23.795 -20.906 1.00 9.56 ? 501 LEU A CD1 1 ATOM 3817 C CD2 . LEU A 1 501 ? 58.988 -24.326 -22.952 1.00 9.54 ? 501 LEU A CD2 1 ATOM 3818 N N . LEU A 1 502 ? 56.331 -24.193 -18.977 1.00 9.12 ? 502 LEU A N 1 ATOM 3819 C CA . LEU A 1 502 ? 55.500 -23.030 -18.667 1.00 9.53 ? 502 LEU A CA 1 ATOM 3820 C C . LEU A 1 502 ? 54.042 -23.444 -18.602 1.00 9.75 ? 502 LEU A C 1 ATOM 3821 O O . LEU A 1 502 ? 53.553 -24.206 -19.486 1.00 9.91 ? 502 LEU A O 1 ATOM 3822 C CB . LEU A 1 502 ? 55.638 -21.985 -19.809 1.00 9.01 ? 502 LEU A CB 1 ATOM 3823 C CG . LEU A 1 502 ? 55.006 -20.628 -19.560 1.00 9.23 ? 502 LEU A CG 1 ATOM 3824 C CD1 . LEU A 1 502 ? 55.790 -19.884 -18.438 1.00 5.82 ? 502 LEU A CD1 1 ATOM 3825 C CD2 . LEU A 1 502 ? 54.921 -19.793 -20.854 1.00 8.43 ? 502 LEU A CD2 1 ATOM 3826 N N . GLY A 1 503 ? 53.308 -22.938 -17.621 1.00 8.79 ? 503 GLY A N 1 ATOM 3827 C CA . GLY A 1 503 ? 51.896 -23.242 -17.650 1.00 8.48 ? 503 GLY A CA 1 ATOM 3828 C C . GLY A 1 503 ? 51.078 -22.741 -16.471 1.00 9.68 ? 503 GLY A C 1 ATOM 3829 O O . GLY A 1 503 ? 51.595 -22.024 -15.618 1.00 8.45 ? 503 GLY A O 1 ATOM 3830 N N . ALA A 1 504 ? 49.796 -23.132 -16.452 1.00 8.52 ? 504 ALA A N 1 ATOM 3831 C CA . ALA A 1 504 ? 48.863 -22.776 -15.394 1.00 10.08 ? 504 ALA A CA 1 ATOM 3832 C C . ALA A 1 504 ? 48.482 -24.063 -14.666 1.00 11.13 ? 504 ALA A C 1 ATOM 3833 O O . ALA A 1 504 ? 47.844 -24.926 -15.236 1.00 10.64 ? 504 ALA A O 1 ATOM 3834 C CB . ALA A 1 504 ? 47.583 -22.118 -15.982 1.00 8.73 ? 504 ALA A CB 1 ATOM 3835 N N . GLY A 1 505 ? 48.839 -24.153 -13.391 1.00 12.86 ? 505 GLY A N 1 ATOM 3836 C CA . GLY A 1 505 ? 48.544 -25.336 -12.607 1.00 14.68 ? 505 GLY A CA 1 ATOM 3837 C C . GLY A 1 505 ? 47.256 -25.147 -11.859 1.00 15.84 ? 505 GLY A C 1 ATOM 3838 O O . GLY A 1 505 ? 46.814 -24.020 -11.670 1.00 15.47 ? 505 GLY A O 1 ATOM 3839 N N . LEU A 1 506 ? 46.640 -26.234 -11.418 1.00 17.39 ? 506 LEU A N 1 ATOM 3840 C CA . LEU A 1 506 ? 45.333 -26.105 -10.755 1.00 18.69 ? 506 LEU A CA 1 ATOM 3841 C C . LEU A 1 506 ? 45.346 -26.511 -9.292 1.00 18.80 ? 506 LEU A C 1 ATOM 3842 O O . LEU A 1 506 ? 46.100 -27.377 -8.911 1.00 17.53 ? 506 LEU A O 1 ATOM 3843 C CB . LEU A 1 506 ? 44.323 -26.981 -11.445 1.00 19.25 ? 506 LEU A CB 1 ATOM 3844 C CG . LEU A 1 506 ? 43.565 -26.584 -12.703 1.00 22.74 ? 506 LEU A CG 1 ATOM 3845 C CD1 . LEU A 1 506 ? 42.320 -27.422 -12.537 1.00 30.58 ? 506 LEU A CD1 1 ATOM 3846 C CD2 . LEU A 1 506 ? 43.129 -25.115 -12.808 1.00 20.25 ? 506 LEU A CD2 1 ATOM 3847 N N . GLU A 1 507 ? 44.509 -25.867 -8.480 1.00 20.05 ? 507 GLU A N 1 ATOM 3848 C CA . GLU A 1 507 ? 44.314 -26.268 -7.088 1.00 21.35 ? 507 GLU A CA 1 ATOM 3849 C C . GLU A 1 507 ? 43.745 -27.678 -7.096 1.00 21.98 ? 507 GLU A C 1 ATOM 3850 O O . GLU A 1 507 ? 43.018 -28.035 -8.000 1.00 20.92 ? 507 GLU A O 1 ATOM 3851 C CB . GLU A 1 507 ? 43.280 -25.391 -6.391 1.00 20.63 ? 507 GLU A CB 1 ATOM 3852 C CG . GLU A 1 507 ? 43.747 -23.976 -6.096 1.00 21.51 ? 507 GLU A CG 1 ATOM 3853 C CD . GLU A 1 507 ? 44.807 -23.959 -5.038 1.00 22.65 ? 507 GLU A CD 1 ATOM 3854 O OE1 . GLU A 1 507 ? 45.841 -23.295 -5.208 1.00 23.44 ? 507 GLU A OE1 1 ATOM 3855 O OE2 . GLU A 1 507 ? 44.612 -24.635 -4.030 1.00 26.84 ? 507 GLU A OE2 1 ATOM 3856 N N . GLY A 1 508 ? 44.045 -28.466 -6.074 1.00 23.45 ? 508 GLY A N 1 ATOM 3857 C CA . GLY A 1 508 ? 43.456 -29.779 -5.993 1.00 25.43 ? 508 GLY A CA 1 ATOM 3858 C C . GLY A 1 508 ? 44.451 -30.933 -5.960 1.00 27.69 ? 508 GLY A C 1 ATOM 3859 O O . GLY A 1 508 ? 45.663 -30.782 -6.197 1.00 26.70 ? 508 GLY A O 1 ATOM 3860 N N . PRO A 1 509 ? 43.900 -32.119 -5.697 1.00 29.02 ? 509 PRO A N 1 ATOM 3861 C CA . PRO A 1 509 ? 44.691 -33.339 -5.581 1.00 29.22 ? 509 PRO A CA 1 ATOM 3862 C C . PRO A 1 509 ? 45.250 -33.636 -6.964 1.00 28.76 ? 509 PRO A C 1 ATOM 3863 O O . PRO A 1 509 ? 44.624 -33.375 -7.978 1.00 28.01 ? 509 PRO A O 1 ATOM 3864 C CB . PRO A 1 509 ? 43.633 -34.386 -5.241 1.00 29.51 ? 509 PRO A CB 1 ATOM 3865 C CG . PRO A 1 509 ? 42.372 -33.824 -5.936 1.00 30.48 ? 509 PRO A CG 1 ATOM 3866 C CD . PRO A 1 509 ? 42.446 -32.373 -5.562 1.00 29.13 ? 509 PRO A CD 1 ATOM 3867 N N . GLY A 1 510 ? 46.433 -34.199 -7.010 1.00 28.90 ? 510 GLY A N 1 ATOM 3868 C CA . GLY A 1 510 ? 46.982 -34.452 -8.296 1.00 29.26 ? 510 GLY A CA 1 ATOM 3869 C C . GLY A 1 510 ? 47.961 -33.343 -8.597 1.00 29.66 ? 510 GLY A C 1 ATOM 3870 O O . GLY A 1 510 ? 48.376 -32.552 -7.742 1.00 29.10 ? 510 GLY A O 1 ATOM 3871 N N . ASP A 1 511 ? 48.230 -33.263 -9.880 1.00 28.72 ? 511 ASP A N 1 ATOM 3872 C CA . ASP A 1 511 ? 49.318 -32.542 -10.454 1.00 28.39 ? 511 ASP A CA 1 ATOM 3873 C C . ASP A 1 511 ? 48.702 -31.886 -11.641 1.00 25.74 ? 511 ASP A C 1 ATOM 3874 O O . ASP A 1 511 ? 49.328 -31.814 -12.683 1.00 25.05 ? 511 ASP A O 1 ATOM 3875 C CB . ASP A 1 511 ? 50.040 -33.674 -11.137 1.00 30.34 ? 511 ASP A CB 1 ATOM 3876 C CG . ASP A 1 511 ? 49.023 -34.530 -11.990 1.00 34.91 ? 511 ASP A CG 1 ATOM 3877 O OD1 . ASP A 1 511 ? 49.360 -34.959 -13.134 1.00 39.18 ? 511 ASP A OD1 1 ATOM 3878 O OD2 . ASP A 1 511 ? 47.822 -34.755 -11.601 1.00 36.28 ? 511 ASP A OD2 1 ATOM 3879 N N . ALA A 1 512 ? 47.455 -31.494 -11.530 1.00 22.61 ? 512 ALA A N 1 ATOM 3880 C CA . ALA A 1 512 ? 46.721 -31.070 -12.702 1.00 20.61 ? 512 ALA A CA 1 ATOM 3881 C C . ALA A 1 512 ? 47.035 -29.673 -13.270 1.00 19.03 ? 512 ALA A C 1 ATOM 3882 O O . ALA A 1 512 ? 47.347 -28.724 -12.540 1.00 17.91 ? 512 ALA A O 1 ATOM 3883 C CB . ALA A 1 512 ? 45.230 -31.228 -12.437 1.00 20.66 ? 512 ALA A CB 1 ATOM 3884 N N . LYS A 1 513 ? 46.924 -29.554 -14.586 1.00 17.44 ? 513 LYS A N 1 ATOM 3885 C CA . LYS A 1 513 ? 47.127 -28.275 -15.246 1.00 17.13 ? 513 LYS A CA 1 ATOM 3886 C C . LYS A 1 513 ? 45.927 -27.851 -16.047 1.00 16.03 ? 513 LYS A C 1 ATOM 3887 O O . LYS A 1 513 ? 45.188 -28.693 -16.571 1.00 17.01 ? 513 LYS A O 1 ATOM 3888 C CB . LYS A 1 513 ? 48.390 -28.317 -16.118 1.00 16.93 ? 513 LYS A CB 1 ATOM 3889 C CG . LYS A 1 513 ? 49.623 -28.271 -15.229 1.00 20.05 ? 513 LYS A CG 1 ATOM 3890 C CD . LYS A 1 513 ? 50.629 -29.286 -15.604 1.00 26.47 ? 513 LYS A CD 1 ATOM 3891 C CE . LYS A 1 513 ? 50.638 -30.447 -14.637 1.00 29.80 ? 513 LYS A CE 1 ATOM 3892 N NZ . LYS A 1 513 ? 52.039 -30.755 -14.226 1.00 33.22 ? 513 LYS A NZ 1 ATOM 3893 N N . LEU A 1 514 ? 45.711 -26.554 -16.125 1.00 13.95 ? 514 LEU A N 1 ATOM 3894 C CA . LEU A 1 514 ? 44.701 -26.056 -17.024 1.00 13.10 ? 514 LEU A CA 1 ATOM 3895 C C . LEU A 1 514 ? 45.247 -26.003 -18.435 1.00 13.11 ? 514 LEU A C 1 ATOM 3896 O O . LEU A 1 514 ? 44.611 -26.481 -19.392 1.00 12.92 ? 514 LEU A O 1 ATOM 3897 C CB . LEU A 1 514 ? 44.273 -24.661 -16.627 1.00 12.04 ? 514 LEU A CB 1 ATOM 3898 C CG . LEU A 1 514 ? 43.106 -24.131 -17.438 1.00 13.57 ? 514 LEU A CG 1 ATOM 3899 C CD1 . LEU A 1 514 ? 41.922 -25.125 -17.450 1.00 15.29 ? 514 LEU A CD1 1 ATOM 3900 C CD2 . LEU A 1 514 ? 42.668 -22.803 -16.852 1.00 15.70 ? 514 LEU A CD2 1 ATOM 3901 N N . LEU A 1 515 ? 46.413 -25.373 -18.592 1.00 12.86 ? 515 LEU A N 1 ATOM 3902 C CA . LEU A 1 515 ? 47.003 -25.253 -19.918 1.00 11.72 ? 515 LEU A CA 1 ATOM 3903 C C . LEU A 1 515 ? 48.482 -25.123 -19.683 1.00 11.95 ? 515 LEU A C 1 ATOM 3904 O O . LEU A 1 515 ? 48.886 -24.534 -18.689 1.00 10.63 ? 515 LEU A O 1 ATOM 3905 C CB . LEU A 1 515 ? 46.463 -24.016 -20.622 1.00 11.27 ? 515 LEU A CB 1 ATOM 3906 C CG . LEU A 1 515 ? 47.018 -23.534 -21.969 1.00 11.51 ? 515 LEU A CG 1 ATOM 3907 C CD1 . LEU A 1 515 ? 46.743 -24.539 -23.040 1.00 12.51 ? 515 LEU A CD1 1 ATOM 3908 C CD2 . LEU A 1 515 ? 46.350 -22.216 -22.390 1.00 10.47 ? 515 LEU A CD2 1 ATOM 3909 N N . GLY A 1 516 ? 49.295 -25.704 -20.568 1.00 11.60 ? 516 GLY A N 1 ATOM 3910 C CA . GLY A 1 516 ? 50.712 -25.613 -20.384 1.00 12.05 ? 516 GLY A CA 1 ATOM 3911 C C . GLY A 1 516 ? 51.499 -26.231 -21.515 1.00 13.33 ? 516 GLY A C 1 ATOM 3912 O O . GLY A 1 516 ? 50.932 -26.691 -22.516 1.00 13.46 ? 516 GLY A O 1 ATOM 3913 N N . LEU A 1 517 ? 52.822 -26.225 -21.349 1.00 13.11 ? 517 LEU A N 1 ATOM 3914 C CA . LEU A 1 517 ? 53.749 -26.715 -22.360 1.00 12.46 ? 517 LEU A CA 1 ATOM 3915 C C . LEU A 1 517 ? 54.921 -27.372 -21.640 1.00 12.19 ? 517 LEU A C 1 ATOM 3916 O O . LEU A 1 517 ? 55.481 -26.816 -20.707 1.00 11.13 ? 517 LEU A O 1 ATOM 3917 C CB . LEU A 1 517 ? 54.264 -25.565 -23.197 1.00 11.51 ? 517 LEU A CB 1 ATOM 3918 C CG . LEU A 1 517 ? 55.323 -25.954 -24.243 1.00 12.04 ? 517 LEU A CG 1 ATOM 3919 C CD1 . LEU A 1 517 ? 54.814 -27.071 -25.203 1.00 10.89 ? 517 LEU A CD1 1 ATOM 3920 C CD2 . LEU A 1 517 ? 55.727 -24.754 -25.092 1.00 11.10 ? 517 LEU A CD2 1 ATOM 3921 N N . SER A 1 518 ? 55.261 -28.560 -22.096 1.00 12.11 ? 518 SER A N 1 ATOM 3922 C CA . SER A 1 518 ? 56.331 -29.350 -21.563 1.00 12.13 ? 518 SER A CA 1 ATOM 3923 C C . SER A 1 518 ? 57.212 -29.730 -22.776 1.00 12.78 ? 518 SER A C 1 ATOM 3924 O O . SER A 1 518 ? 56.836 -29.448 -23.910 1.00 12.60 ? 518 SER A O 1 ATOM 3925 C CB . SER A 1 518 ? 55.713 -30.574 -20.884 1.00 12.69 ? 518 SER A CB 1 ATOM 3926 O OG . SER A 1 518 ? 55.275 -30.298 -19.538 1.00 13.06 ? 518 SER A OG 1 ATOM 3927 N N . TYR A 1 519 ? 58.392 -30.315 -22.553 1.00 12.49 ? 519 TYR A N 1 ATOM 3928 C CA . TYR A 1 519 ? 59.277 -30.687 -23.659 1.00 11.94 ? 519 TYR A CA 1 ATOM 3929 C C . TYR A 1 519 ? 59.835 -32.047 -23.289 1.00 13.04 ? 519 TYR A C 1 ATOM 3930 O O . TYR A 1 519 ? 59.851 -32.401 -22.091 1.00 13.01 ? 519 TYR A O 1 ATOM 3931 C CB . TYR A 1 519 ? 60.396 -29.657 -23.866 1.00 11.07 ? 519 TYR A CB 1 ATOM 3932 C CG . TYR A 1 519 ? 61.233 -29.460 -22.626 1.00 10.80 ? 519 TYR A CG 1 ATOM 3933 C CD1 . TYR A 1 519 ? 62.482 -30.011 -22.528 1.00 9.36 ? 519 TYR A CD1 1 ATOM 3934 C CD2 . TYR A 1 519 ? 60.757 -28.710 -21.560 1.00 8.67 ? 519 TYR A CD2 1 ATOM 3935 C CE1 . TYR A 1 519 ? 63.243 -29.847 -21.378 1.00 12.51 ? 519 TYR A CE1 1 ATOM 3936 C CE2 . TYR A 1 519 ? 61.477 -28.540 -20.427 1.00 9.10 ? 519 TYR A CE2 1 ATOM 3937 C CZ . TYR A 1 519 ? 62.722 -29.115 -20.316 1.00 12.89 ? 519 TYR A CZ 1 ATOM 3938 O OH . TYR A 1 519 ? 63.468 -28.930 -19.148 1.00 11.41 ? 519 TYR A OH 1 ATOM 3939 N N . ASP A 1 520 ? 60.317 -32.801 -24.281 1.00 12.99 ? 520 ASP A N 1 ATOM 3940 C CA . ASP A 1 520 ? 60.732 -34.178 -24.009 1.00 13.52 ? 520 ASP A CA 1 ATOM 3941 C C . ASP A 1 520 ? 62.102 -34.608 -24.544 1.00 13.26 ? 520 ASP A C 1 ATOM 3942 O O . ASP A 1 520 ? 62.768 -33.841 -25.199 1.00 12.42 ? 520 ASP A O 1 ATOM 3943 C CB . ASP A 1 520 ? 59.606 -35.194 -24.319 1.00 12.42 ? 520 ASP A CB 1 ATOM 3944 C CG . ASP A 1 520 ? 59.391 -35.455 -25.824 1.00 14.02 ? 520 ASP A CG 1 ATOM 3945 O OD1 . ASP A 1 520 ? 60.308 -35.228 -26.645 1.00 12.49 ? 520 ASP A OD1 1 ATOM 3946 O OD2 . ASP A 1 520 ? 58.326 -35.951 -26.270 1.00 13.91 ? 520 ASP A OD2 1 ATOM 3947 N N . LYS A 1 521 ? 62.503 -35.840 -24.242 1.00 13.95 ? 521 LYS A N 1 ATOM 3948 C CA . LYS A 1 521 ? 63.860 -36.333 -24.583 1.00 15.72 ? 521 LYS A CA 1 ATOM 3949 C C . LYS A 1 521 ? 64.057 -36.584 -26.078 1.00 15.54 ? 521 LYS A C 1 ATOM 3950 O O . LYS A 1 521 ? 65.174 -36.821 -26.526 1.00 15.59 ? 521 LYS A O 1 ATOM 3951 C CB . LYS A 1 521 ? 64.172 -37.653 -23.820 1.00 16.05 ? 521 LYS A CB 1 ATOM 3952 C CG . LYS A 1 521 ? 63.214 -38.807 -24.260 1.00 20.37 ? 521 LYS A CG 1 ATOM 3953 C CD . LYS A 1 521 ? 63.368 -40.171 -23.504 1.00 26.69 ? 521 LYS A CD 1 ATOM 3954 C CE . LYS A 1 521 ? 64.513 -41.093 -24.028 1.00 33.30 ? 521 LYS A CE 1 ATOM 3955 N NZ . LYS A 1 521 ? 64.681 -42.441 -23.241 1.00 32.83 ? 521 LYS A NZ 1 ATOM 3956 N N . ASN A 1 522 ? 62.973 -36.552 -26.848 1.00 15.25 ? 522 ASN A N 1 ATOM 3957 C CA . ASN A 1 522 ? 63.070 -36.739 -28.295 1.00 15.51 ? 522 ASN A CA 1 ATOM 3958 C C . ASN A 1 522 ? 63.097 -35.381 -28.991 1.00 15.24 ? 522 ASN A C 1 ATOM 3959 O O . ASN A 1 522 ? 62.991 -35.323 -30.211 1.00 15.32 ? 522 ASN A O 1 ATOM 3960 C CB . ASN A 1 522 ? 61.879 -37.541 -28.826 1.00 14.59 ? 522 ASN A CB 1 ATOM 3961 C CG . ASN A 1 522 ? 61.774 -38.918 -28.207 1.00 17.16 ? 522 ASN A CG 1 ATOM 3962 O OD1 . ASN A 1 522 ? 62.778 -39.602 -28.005 1.00 18.05 ? 522 ASN A OD1 1 ATOM 3963 N ND2 . ASN A 1 522 ? 60.551 -39.333 -27.899 1.00 16.78 ? 522 ASN A ND2 1 ATOM 3964 N N . ARG A 1 523 ? 63.205 -34.311 -28.201 1.00 14.30 ? 523 ARG A N 1 ATOM 3965 C CA . ARG A 1 523 ? 63.179 -32.931 -28.709 1.00 13.73 ? 523 ARG A CA 1 ATOM 3966 C C . ARG A 1 523 ? 61.857 -32.558 -29.338 1.00 13.28 ? 523 ARG A C 1 ATOM 3967 O O . ARG A 1 523 ? 61.759 -31.865 -30.358 1.00 13.02 ? 523 ARG A O 1 ATOM 3968 C CB . ARG A 1 523 ? 64.355 -32.624 -29.605 1.00 14.24 ? 523 ARG A CB 1 ATOM 3969 C CG . ARG A 1 523 ? 65.692 -32.790 -28.859 1.00 15.98 ? 523 ARG A CG 1 ATOM 3970 C CD . ARG A 1 523 ? 66.923 -32.240 -29.577 1.00 20.67 ? 523 ARG A CD 1 ATOM 3971 N NE . ARG A 1 523 ? 67.329 -33.063 -30.717 1.00 25.41 ? 523 ARG A NE 1 ATOM 3972 C CZ . ARG A 1 523 ? 67.175 -32.707 -31.987 1.00 30.00 ? 523 ARG A CZ 1 ATOM 3973 N NH1 . ARG A 1 523 ? 66.593 -31.544 -32.290 1.00 31.36 ? 523 ARG A NH1 1 ATOM 3974 N NH2 . ARG A 1 523 ? 67.587 -33.510 -32.965 1.00 30.98 ? 523 ARG A NH2 1 ATOM 3975 N N . GLN A 1 524 ? 60.803 -33.014 -28.688 1.00 13.00 ? 524 GLN A N 1 ATOM 3976 C CA . GLN A 1 524 ? 59.502 -32.610 -29.122 1.00 12.29 ? 524 GLN A CA 1 ATOM 3977 C C . GLN A 1 524 ? 58.840 -31.778 -28.026 1.00 12.14 ? 524 GLN A C 1 ATOM 3978 O O . GLN A 1 524 ? 59.201 -31.837 -26.854 1.00 11.13 ? 524 GLN A O 1 ATOM 3979 C CB . GLN A 1 524 ? 58.631 -33.823 -29.467 1.00 12.02 ? 524 GLN A CB 1 ATOM 3980 C CG . GLN A 1 524 ? 59.144 -34.694 -30.655 1.00 12.47 ? 524 GLN A CG 1 ATOM 3981 C CD . GLN A 1 524 ? 58.014 -35.493 -31.286 1.00 14.25 ? 524 GLN A CD 1 ATOM 3982 O OE1 . GLN A 1 524 ? 57.693 -36.605 -30.823 1.00 14.26 ? 524 GLN A OE1 1 ATOM 3983 N NE2 . GLN A 1 524 ? 57.344 -34.891 -32.296 1.00 12.48 ? 524 GLN A NE2 1 ATOM 3984 N N . TRP A 1 525 ? 57.859 -31.004 -28.459 1.00 12.13 ? 525 TRP A N 1 ATOM 3985 C CA . TRP A 1 525 ? 56.985 -30.285 -27.586 1.00 13.09 ? 525 TRP A CA 1 ATOM 3986 C C . TRP A 1 525 ? 55.857 -31.189 -27.102 1.00 13.44 ? 525 TRP A C 1 ATOM 3987 O O . TRP A 1 525 ? 55.370 -32.043 -27.821 1.00 12.75 ? 525 TRP A O 1 ATOM 3988 C CB . TRP A 1 525 ? 56.372 -29.083 -28.337 1.00 11.51 ? 525 TRP A CB 1 ATOM 3989 C CG . TRP A 1 525 ? 57.353 -28.062 -28.858 1.00 11.97 ? 525 TRP A CG 1 ATOM 3990 C CD1 . TRP A 1 525 ? 57.591 -27.718 -30.173 1.00 10.45 ? 525 TRP A CD1 1 ATOM 3991 C CD2 . TRP A 1 525 ? 58.182 -27.202 -28.067 1.00 12.17 ? 525 TRP A CD2 1 ATOM 3992 N NE1 . TRP A 1 525 ? 58.507 -26.694 -30.226 1.00 12.77 ? 525 TRP A NE1 1 ATOM 3993 C CE2 . TRP A 1 525 ? 58.882 -26.356 -28.949 1.00 11.70 ? 525 TRP A CE2 1 ATOM 3994 C CE3 . TRP A 1 525 ? 58.382 -27.050 -26.688 1.00 11.16 ? 525 TRP A CE3 1 ATOM 3995 C CZ2 . TRP A 1 525 ? 59.794 -25.397 -28.505 1.00 10.66 ? 525 TRP A CZ2 1 ATOM 3996 C CZ3 . TRP A 1 525 ? 59.280 -26.124 -26.248 1.00 13.34 ? 525 TRP A CZ3 1 ATOM 3997 C CH2 . TRP A 1 525 ? 59.976 -25.288 -27.152 1.00 12.26 ? 525 TRP A CH2 1 ATOM 3998 N N . ARG A 1 526 ? 55.404 -30.880 -25.895 1.00 14.31 ? 526 ARG A N 1 ATOM 3999 C CA . ARG A 1 526 ? 54.284 -31.543 -25.271 1.00 14.78 ? 526 ARG A CA 1 ATOM 4000 C C . ARG A 1 526 ? 53.353 -30.505 -24.635 1.00 14.31 ? 526 ARG A C 1 ATOM 4001 O O . ARG A 1 526 ? 53.497 -30.162 -23.470 1.00 13.55 ? 526 ARG A O 1 ATOM 4002 C CB . ARG A 1 526 ? 54.782 -32.569 -24.232 1.00 15.05 ? 526 ARG A CB 1 ATOM 4003 C CG . ARG A 1 526 ? 55.051 -33.951 -24.844 1.00 19.54 ? 526 ARG A CG 1 ATOM 4004 C CD . ARG A 1 526 ? 55.445 -34.984 -23.798 1.00 27.60 ? 526 ARG A CD 1 ATOM 4005 N NE . ARG A 1 526 ? 56.304 -36.056 -24.317 1.00 30.47 ? 526 ARG A NE 1 ATOM 4006 C CZ . ARG A 1 526 ? 55.930 -37.324 -24.361 1.00 32.79 ? 526 ARG A CZ 1 ATOM 4007 N NH1 . ARG A 1 526 ? 54.712 -37.658 -23.937 1.00 32.47 ? 526 ARG A NH1 1 ATOM 4008 N NH2 . ARG A 1 526 ? 56.754 -38.247 -24.837 1.00 33.74 ? 526 ARG A NH2 1 ATOM 4009 N N . PRO A 1 527 ? 52.437 -29.966 -25.437 1.00 14.25 ? 527 PRO A N 1 ATOM 4010 C CA . PRO A 1 527 ? 51.422 -29.037 -24.953 1.00 14.17 ? 527 PRO A CA 1 ATOM 4011 C C . PRO A 1 527 ? 50.402 -29.795 -24.162 1.00 14.78 ? 527 PRO A C 1 ATOM 4012 O O . PRO A 1 527 ? 50.034 -30.904 -24.528 1.00 15.70 ? 527 PRO A O 1 ATOM 4013 C CB . PRO A 1 527 ? 50.796 -28.515 -26.253 1.00 14.55 ? 527 PRO A CB 1 ATOM 4014 C CG . PRO A 1 527 ? 50.973 -29.682 -27.190 1.00 13.29 ? 527 PRO A CG 1 ATOM 4015 C CD . PRO A 1 527 ? 52.371 -30.132 -26.901 1.00 13.77 ? 527 PRO A CD 1 ATOM 4016 N N . LEU A 1 528 ? 49.933 -29.188 -23.088 1.00 15.59 ? 528 LEU A N 1 ATOM 4017 C CA . LEU A 1 528 ? 48.971 -29.796 -22.194 1.00 16.48 ? 528 LEU A CA 1 ATOM 4018 C C . LEU A 1 528 ? 47.660 -29.059 -22.250 1.00 17.45 ? 528 LEU A C 1 ATOM 4019 O O . LEU A 1 528 ? 47.550 -27.894 -21.845 1.00 17.79 ? 528 LEU A O 1 ATOM 4020 C CB . LEU A 1 528 ? 49.511 -29.746 -20.762 1.00 17.00 ? 528 LEU A CB 1 ATOM 4021 C CG . LEU A 1 528 ? 50.989 -30.133 -20.625 1.00 19.00 ? 528 LEU A CG 1 ATOM 4022 C CD1 . LEU A 1 528 ? 51.531 -29.892 -19.200 1.00 21.55 ? 528 LEU A CD1 1 ATOM 4023 C CD2 . LEU A 1 528 ? 51.188 -31.581 -20.999 1.00 20.07 ? 528 LEU A CD2 1 ATOM 4024 N N . TYR A 1 529 ? 46.635 -29.748 -22.708 1.00 18.70 ? 529 TYR A N 1 ATOM 4025 C CA . TYR A 1 529 ? 45.325 -29.140 -22.813 1.00 20.40 ? 529 TYR A CA 1 ATOM 4026 C C . TYR A 1 529 ? 44.395 -29.708 -21.781 1.00 21.95 ? 529 TYR A C 1 ATOM 4027 O O . TYR A 1 529 ? 43.719 -30.710 -22.043 1.00 23.35 ? 529 TYR A O 1 ATOM 4028 C CB . TYR A 1 529 ? 44.739 -29.441 -24.187 1.00 20.32 ? 529 TYR A CB 1 ATOM 4029 C CG . TYR A 1 529 ? 45.633 -28.960 -25.282 1.00 19.78 ? 529 TYR A CG 1 ATOM 4030 C CD1 . TYR A 1 529 ? 46.460 -29.824 -25.963 1.00 17.88 ? 529 TYR A CD1 1 ATOM 4031 C CD2 . TYR A 1 529 ? 45.663 -27.622 -25.619 1.00 18.78 ? 529 TYR A CD2 1 ATOM 4032 C CE1 . TYR A 1 529 ? 47.308 -29.353 -26.975 1.00 19.75 ? 529 TYR A CE1 1 ATOM 4033 C CE2 . TYR A 1 529 ? 46.499 -27.147 -26.622 1.00 17.01 ? 529 TYR A CE2 1 ATOM 4034 C CZ . TYR A 1 529 ? 47.321 -28.016 -27.297 1.00 18.88 ? 529 TYR A CZ 1 ATOM 4035 O OH . TYR A 1 529 ? 48.159 -27.550 -28.294 1.00 18.91 ? 529 TYR A OH 1 ATOM 4036 N N . GLY A 1 530 ? 44.324 -29.088 -20.614 1.00 22.95 ? 530 GLY A N 1 ATOM 4037 C CA . GLY A 1 530 ? 43.408 -29.582 -19.612 1.00 24.16 ? 530 GLY A CA 1 ATOM 4038 C C . GLY A 1 530 ? 43.827 -30.973 -19.169 1.00 25.97 ? 530 GLY A C 1 ATOM 4039 O O . GLY A 1 530 ? 45.001 -31.220 -18.894 1.00 24.97 ? 530 GLY A O 1 ATOM 4040 N N . ALA A 1 531 ? 42.894 -31.907 -19.093 1.00 27.15 ? 531 ALA A N 1 ATOM 4041 C CA . ALA A 1 531 ? 43.301 -33.192 -18.532 1.00 29.65 ? 531 ALA A CA 1 ATOM 4042 C C . ALA A 1 531 ? 43.662 -34.254 -19.566 1.00 30.90 ? 531 ALA A C 1 ATOM 4043 O O . ALA A 1 531 ? 44.064 -35.361 -19.195 1.00 31.90 ? 531 ALA A O 1 ATOM 4044 C CB . ALA A 1 531 ? 42.263 -33.728 -17.516 1.00 29.54 ? 531 ALA A CB 1 ATOM 4045 N N . ALA A 1 532 ? 43.511 -33.915 -20.844 1.00 32.17 ? 532 ALA A N 1 ATOM 4046 C CA . ALA A 1 532 ? 43.841 -34.820 -21.951 1.00 33.61 ? 532 ALA A CA 1 ATOM 4047 C C . ALA A 1 532 ? 45.311 -35.224 -21.928 1.00 34.45 ? 532 ALA A C 1 ATOM 4048 O O . ALA A 1 532 ? 46.175 -34.446 -21.494 1.00 34.44 ? 532 ALA A O 1 ATOM 4049 C CB . ALA A 1 532 ? 43.461 -34.158 -23.331 1.00 33.48 ? 532 ALA A CB 1 ATOM 4050 N N . PRO A 1 533 ? 45.600 -36.456 -22.343 1.00 35.64 ? 533 PRO A N 1 ATOM 4051 C CA . PRO A 1 533 ? 46.986 -36.941 -22.397 1.00 35.69 ? 533 PRO A CA 1 ATOM 4052 C C . PRO A 1 533 ? 47.772 -36.112 -23.387 1.00 35.32 ? 533 PRO A C 1 ATOM 4053 O O . PRO A 1 533 ? 47.262 -35.852 -24.468 1.00 35.41 ? 533 PRO A O 1 ATOM 4054 C CB . PRO A 1 533 ? 46.843 -38.352 -22.982 1.00 36.25 ? 533 PRO A CB 1 ATOM 4055 C CG . PRO A 1 533 ? 45.534 -38.290 -23.728 1.00 36.60 ? 533 PRO A CG 1 ATOM 4056 C CD . PRO A 1 533 ? 44.646 -37.500 -22.755 1.00 36.29 ? 533 PRO A CD 1 ATOM 4057 N N . ALA A 1 534 ? 48.980 -35.696 -23.021 1.00 34.44 ? 534 ALA A N 1 ATOM 4058 C CA . ALA A 1 534 ? 49.834 -34.996 -23.958 1.00 33.47 ? 534 ALA A CA 1 ATOM 4059 C C . ALA A 1 534 ? 50.196 -35.975 -25.068 1.00 32.67 ? 534 ALA A C 1 ATOM 4060 O O . ALA A 1 534 ? 50.246 -37.194 -24.839 1.00 34.12 ? 534 ALA A O 1 ATOM 4061 C CB . ALA A 1 534 ? 51.097 -34.545 -23.273 1.00 33.35 ? 534 ALA A CB 1 ATOM 4062 N N . SER A 1 535 ? 50.386 -35.465 -26.271 1.00 30.18 ? 535 SER A N 1 ATOM 4063 C CA . SER A 1 535 ? 50.978 -36.257 -27.340 1.00 28.91 ? 535 SER A CA 1 ATOM 4064 C C . SER A 1 535 ? 51.981 -35.280 -27.875 1.00 25.87 ? 535 SER A C 1 ATOM 4065 O O . SER A 1 535 ? 51.676 -34.114 -28.058 1.00 26.68 ? 535 SER A O 1 ATOM 4066 C CB . SER A 1 535 ? 49.985 -36.638 -28.434 1.00 28.38 ? 535 SER A CB 1 ATOM 4067 O OG . SER A 1 535 ? 48.998 -35.643 -28.503 1.00 30.85 ? 535 SER A OG 1 ATOM 4068 N N . PRO A 1 536 ? 53.186 -35.758 -28.113 1.00 23.55 ? 536 PRO A N 1 ATOM 4069 C CA . PRO A 1 536 ? 54.259 -34.908 -28.609 1.00 21.66 ? 536 PRO A CA 1 ATOM 4070 C C . PRO A 1 536 ? 53.948 -34.439 -30.007 1.00 20.17 ? 536 PRO A C 1 ATOM 4071 O O . PRO A 1 536 ? 53.200 -35.087 -30.736 1.00 19.36 ? 536 PRO A O 1 ATOM 4072 C CB . PRO A 1 536 ? 55.484 -35.833 -28.616 1.00 21.63 ? 536 PRO A CB 1 ATOM 4073 C CG . PRO A 1 536 ? 55.043 -37.173 -28.077 1.00 22.40 ? 536 PRO A CG 1 ATOM 4074 C CD . PRO A 1 536 ? 53.570 -37.178 -27.973 1.00 23.60 ? 536 PRO A CD 1 ATOM 4075 N N . THR A 1 537 ? 54.516 -33.297 -30.367 1.00 18.26 ? 537 THR A N 1 ATOM 4076 C CA . THR A 1 537 ? 54.356 -32.747 -31.686 1.00 16.14 ? 537 THR A CA 1 ATOM 4077 C C . THR A 1 537 ? 55.575 -31.890 -31.970 1.00 15.90 ? 537 THR A C 1 ATOM 4078 O O . THR A 1 537 ? 56.258 -31.419 -31.043 1.00 15.76 ? 537 THR A O 1 ATOM 4079 C CB . THR A 1 537 ? 53.021 -31.949 -31.787 1.00 16.73 ? 537 THR A CB 1 ATOM 4080 O OG1 . THR A 1 537 ? 52.927 -31.305 -33.083 1.00 14.26 ? 537 THR A OG1 1 ATOM 4081 C CG2 . THR A 1 537 ? 52.976 -30.791 -30.723 1.00 14.87 ? 537 THR A CG2 1 ATOM 4082 N N . GLY A 1 538 ? 55.893 -31.730 -33.245 1.00 15.25 ? 538 GLY A N 1 ATOM 4083 C CA . GLY A 1 538 ? 56.951 -30.819 -33.671 1.00 14.35 ? 538 GLY A CA 1 ATOM 4084 C C . GLY A 1 538 ? 58.400 -31.119 -33.304 1.00 14.80 ? 538 GLY A C 1 ATOM 4085 O O . GLY A 1 538 ? 58.766 -32.254 -32.954 1.00 14.99 ? 538 GLY A O 1 ATOM 4086 N N . SER A 1 539 ? 59.241 -30.093 -33.400 1.00 14.41 ? 539 SER A N 1 ATOM 4087 C CA . SER A 1 539 ? 60.673 -30.266 -33.208 1.00 14.62 ? 539 SER A CA 1 ATOM 4088 C C . SER A 1 539 ? 61.296 -28.973 -32.691 1.00 14.40 ? 539 SER A C 1 ATOM 4089 O O . SER A 1 539 ? 60.913 -27.881 -33.106 1.00 14.72 ? 539 SER A O 1 ATOM 4090 C CB . SER A 1 539 ? 61.298 -30.564 -34.572 1.00 15.09 ? 539 SER A CB 1 ATOM 4091 O OG . SER A 1 539 ? 62.683 -30.900 -34.489 1.00 15.69 ? 539 SER A OG 1 ATOM 4092 N N . TRP A 1 540 ? 62.234 -29.083 -31.766 1.00 14.40 ? 540 TRP A N 1 ATOM 4093 C CA . TRP A 1 540 ? 63.015 -27.914 -31.332 1.00 14.55 ? 540 TRP A CA 1 ATOM 4094 C C . TRP A 1 540 ? 64.482 -28.346 -31.181 1.00 14.05 ? 540 TRP A C 1 ATOM 4095 O O . TRP A 1 540 ? 64.801 -29.516 -31.200 1.00 14.25 ? 540 TRP A O 1 ATOM 4096 C CB . TRP A 1 540 ? 62.472 -27.330 -30.027 1.00 14.41 ? 540 TRP A CB 1 ATOM 4097 C CG . TRP A 1 540 ? 62.338 -28.370 -28.933 1.00 15.99 ? 540 TRP A CG 1 ATOM 4098 C CD1 . TRP A 1 540 ? 61.202 -29.033 -28.573 1.00 14.44 ? 540 TRP A CD1 1 ATOM 4099 C CD2 . TRP A 1 540 ? 63.378 -28.863 -28.077 1.00 15.12 ? 540 TRP A CD2 1 ATOM 4100 N NE1 . TRP A 1 540 ? 61.469 -29.903 -27.546 1.00 13.77 ? 540 TRP A NE1 1 ATOM 4101 C CE2 . TRP A 1 540 ? 62.793 -29.800 -27.210 1.00 15.49 ? 540 TRP A CE2 1 ATOM 4102 C CE3 . TRP A 1 540 ? 64.745 -28.592 -27.944 1.00 17.38 ? 540 TRP A CE3 1 ATOM 4103 C CZ2 . TRP A 1 540 ? 63.534 -30.521 -26.257 1.00 16.94 ? 540 TRP A CZ2 1 ATOM 4104 C CZ3 . TRP A 1 540 ? 65.472 -29.261 -26.972 1.00 18.19 ? 540 TRP A CZ3 1 ATOM 4105 C CH2 . TRP A 1 540 ? 64.865 -30.237 -26.145 1.00 16.10 ? 540 TRP A CH2 1 ATOM 4106 N N . GLU A 1 541 ? 65.365 -27.397 -31.001 1.00 14.59 ? 541 GLU A N 1 ATOM 4107 C CA . GLU A 1 541 ? 66.789 -27.692 -30.832 1.00 14.39 ? 541 GLU A CA 1 ATOM 4108 C C . GLU A 1 541 ? 67.304 -27.079 -29.521 1.00 14.24 ? 541 GLU A C 1 ATOM 4109 O O . GLU A 1 541 ? 66.824 -26.004 -29.107 1.00 14.42 ? 541 GLU A O 1 ATOM 4110 C CB . GLU A 1 541 ? 67.560 -27.134 -32.031 1.00 14.16 ? 541 GLU A CB 1 ATOM 4111 N N . LEU A 1 542 ? 68.215 -27.766 -28.840 1.00 13.59 ? 542 LEU A N 1 ATOM 4112 C CA . LEU A 1 542 ? 68.838 -27.237 -27.635 1.00 15.58 ? 542 LEU A CA 1 ATOM 4113 C C . LEU A 1 542 ? 69.450 -25.911 -27.913 1.00 15.71 ? 542 LEU A C 1 ATOM 4114 O O . LEU A 1 542 ? 70.055 -25.730 -28.966 1.00 15.48 ? 542 LEU A O 1 ATOM 4115 C CB . LEU A 1 542 ? 70.053 -28.034 -27.245 1.00 16.14 ? 542 LEU A CB 1 ATOM 4116 C CG . LEU A 1 542 ? 69.896 -29.308 -26.460 1.00 18.95 ? 542 LEU A CG 1 ATOM 4117 C CD1 . LEU A 1 542 ? 71.293 -29.890 -26.192 1.00 19.77 ? 542 LEU A CD1 1 ATOM 4118 C CD2 . LEU A 1 542 ? 69.131 -29.084 -25.183 1.00 13.59 ? 542 LEU A CD2 1 ATOM 4119 N N . HIS A 1 543 ? 69.374 -25.040 -26.912 1.00 16.16 ? 543 HIS A N 1 ATOM 4120 C CA . HIS A 1 543 ? 70.004 -23.726 -26.915 1.00 17.34 ? 543 HIS A CA 1 ATOM 4121 C C . HIS A 1 543 ? 69.449 -22.761 -27.911 1.00 16.93 ? 543 HIS A C 1 ATOM 4122 O O . HIS A 1 543 ? 70.017 -21.725 -28.075 1.00 19.39 ? 543 HIS A O 1 ATOM 4123 C CB . HIS A 1 543 ? 71.516 -23.836 -27.139 1.00 17.29 ? 543 HIS A CB 1 ATOM 4124 C CG . HIS A 1 543 ? 72.180 -24.831 -26.242 1.00 19.43 ? 543 HIS A CG 1 ATOM 4125 N ND1 . HIS A 1 543 ? 72.854 -25.935 -26.720 1.00 16.36 ? 543 HIS A ND1 1 ATOM 4126 C CD2 . HIS A 1 543 ? 72.269 -24.887 -24.888 1.00 18.47 ? 543 HIS A CD2 1 ATOM 4127 C CE1 . HIS A 1 543 ? 73.324 -26.631 -25.700 1.00 19.22 ? 543 HIS A CE1 1 ATOM 4128 N NE2 . HIS A 1 543 ? 72.974 -26.022 -24.575 1.00 18.95 ? 543 HIS A NE2 1 ATOM 4129 N N . LYS A 1 544 ? 68.376 -23.093 -28.605 1.00 16.10 ? 544 LYS A N 1 ATOM 4130 C CA . LYS A 1 544 ? 67.835 -22.131 -29.550 1.00 15.12 ? 544 LYS A CA 1 ATOM 4131 C C . LYS A 1 544 ? 66.717 -21.352 -28.837 1.00 13.97 ? 544 LYS A C 1 ATOM 4132 O O . LYS A 1 544 ? 66.008 -21.932 -28.034 1.00 11.55 ? 544 LYS A O 1 ATOM 4133 C CB . LYS A 1 544 ? 67.308 -22.877 -30.754 1.00 15.87 ? 544 LYS A CB 1 ATOM 4134 C CG . LYS A 1 544 ? 66.524 -22.032 -31.764 1.00 19.78 ? 544 LYS A CG 1 ATOM 4135 C CD . LYS A 1 544 ? 66.572 -22.720 -33.128 1.00 23.48 ? 544 LYS A CD 1 ATOM 4136 C CE . LYS A 1 544 ? 65.605 -22.098 -34.161 1.00 28.17 ? 544 LYS A CE 1 ATOM 4137 N NZ . LYS A 1 544 ? 65.895 -20.672 -34.498 1.00 27.16 ? 544 LYS A NZ 1 ATOM 4138 N N . LYS A 1 545 ? 66.591 -20.054 -29.112 1.00 12.61 ? 545 LYS A N 1 ATOM 4139 C CA . LYS A 1 545 ? 65.574 -19.245 -28.452 1.00 13.25 ? 545 LYS A CA 1 ATOM 4140 C C . LYS A 1 545 ? 64.200 -19.457 -29.077 1.00 12.02 ? 545 LYS A C 1 ATOM 4141 O O . LYS A 1 545 ? 64.079 -19.389 -30.267 1.00 11.99 ? 545 LYS A O 1 ATOM 4142 C CB . LYS A 1 545 ? 65.943 -17.749 -28.495 1.00 13.48 ? 545 LYS A CB 1 ATOM 4143 N N . TYR A 1 546 ? 63.184 -19.728 -28.260 1.00 11.69 ? 546 TYR A N 1 ATOM 4144 C CA . TYR A 1 546 ? 61.816 -19.899 -28.728 1.00 10.70 ? 546 TYR A CA 1 ATOM 4145 C C . TYR A 1 546 ? 60.865 -18.929 -28.042 1.00 11.07 ? 546 TYR A C 1 ATOM 4146 O O . TYR A 1 546 ? 61.014 -18.636 -26.850 1.00 11.81 ? 546 TYR A O 1 ATOM 4147 C CB . TYR A 1 546 ? 61.337 -21.328 -28.497 1.00 11.55 ? 546 TYR A CB 1 ATOM 4148 C CG . TYR A 1 546 ? 62.050 -22.326 -29.392 1.00 11.80 ? 546 TYR A CG 1 ATOM 4149 C CD1 . TYR A 1 546 ? 63.063 -23.145 -28.890 1.00 11.28 ? 546 TYR A CD1 1 ATOM 4150 C CD2 . TYR A 1 546 ? 61.764 -22.389 -30.758 1.00 12.05 ? 546 TYR A CD2 1 ATOM 4151 C CE1 . TYR A 1 546 ? 63.745 -24.015 -29.704 1.00 11.69 ? 546 TYR A CE1 1 ATOM 4152 C CE2 . TYR A 1 546 ? 62.442 -23.273 -31.587 1.00 13.86 ? 546 TYR A CE2 1 ATOM 4153 C CZ . TYR A 1 546 ? 63.439 -24.084 -31.053 1.00 13.60 ? 546 TYR A CZ 1 ATOM 4154 O OH . TYR A 1 546 ? 64.120 -24.959 -31.886 1.00 14.79 ? 546 TYR A OH 1 ATOM 4155 N N . HIS A 1 547 ? 59.878 -18.434 -28.785 1.00 8.84 ? 547 HIS A N 1 ATOM 4156 C CA . HIS A 1 547 ? 58.894 -17.559 -28.220 1.00 9.11 ? 547 HIS A CA 1 ATOM 4157 C C . HIS A 1 547 ? 57.680 -18.422 -27.875 1.00 9.37 ? 547 HIS A C 1 ATOM 4158 O O . HIS A 1 547 ? 57.152 -19.083 -28.754 1.00 10.00 ? 547 HIS A O 1 ATOM 4159 C CB . HIS A 1 547 ? 58.501 -16.503 -29.238 1.00 8.02 ? 547 HIS A CB 1 ATOM 4160 C CG . HIS A 1 547 ? 57.496 -15.504 -28.738 1.00 8.89 ? 547 HIS A CG 1 ATOM 4161 N ND1 . HIS A 1 547 ? 57.842 -14.481 -27.883 1.00 8.92 ? 547 HIS A ND1 1 ATOM 4162 C CD2 . HIS A 1 547 ? 56.192 -15.302 -29.053 1.00 5.80 ? 547 HIS A CD2 1 ATOM 4163 C CE1 . HIS A 1 547 ? 56.798 -13.690 -27.684 1.00 7.18 ? 547 HIS A CE1 1 ATOM 4164 N NE2 . HIS A 1 547 ? 55.776 -14.191 -28.358 1.00 9.83 ? 547 HIS A NE2 1 ATOM 4165 N N . VAL A 1 548 ? 57.248 -18.427 -26.611 1.00 10.00 ? 548 VAL A N 1 ATOM 4166 C CA . VAL A 1 548 ? 56.096 -19.230 -26.195 1.00 10.74 ? 548 VAL A CA 1 ATOM 4167 C C . VAL A 1 548 ? 54.908 -18.405 -25.741 1.00 11.44 ? 548 VAL A C 1 ATOM 4168 O O . VAL A 1 548 ? 55.051 -17.504 -24.932 1.00 11.76 ? 548 VAL A O 1 ATOM 4169 C CB . VAL A 1 548 ? 56.437 -20.144 -25.001 1.00 10.40 ? 548 VAL A CB 1 ATOM 4170 C CG1 . VAL A 1 548 ? 55.218 -20.908 -24.561 1.00 10.30 ? 548 VAL A CG1 1 ATOM 4171 C CG2 . VAL A 1 548 ? 57.569 -21.072 -25.335 1.00 10.37 ? 548 VAL A CG2 1 ATOM 4172 N N . VAL A 1 549 ? 53.722 -18.753 -26.223 1.00 12.07 ? 549 VAL A N 1 ATOM 4173 C CA . VAL A 1 549 ? 52.524 -18.060 -25.779 1.00 12.04 ? 549 VAL A CA 1 ATOM 4174 C C . VAL A 1 549 ? 51.405 -19.031 -25.464 1.00 11.77 ? 549 VAL A C 1 ATOM 4175 O O . VAL A 1 549 ? 51.103 -19.896 -26.256 1.00 10.47 ? 549 VAL A O 1 ATOM 4176 C CB . VAL A 1 549 ? 52.001 -17.074 -26.856 1.00 12.64 ? 549 VAL A CB 1 ATOM 4177 C CG1 . VAL A 1 549 ? 50.621 -16.542 -26.480 1.00 11.35 ? 549 VAL A CG1 1 ATOM 4178 C CG2 . VAL A 1 549 ? 52.962 -15.868 -27.059 1.00 13.89 ? 549 VAL A CG2 1 ATOM 4179 N N . LEU A 1 550 ? 50.786 -18.877 -24.304 1.00 11.10 ? 550 LEU A N 1 ATOM 4180 C CA . LEU A 1 550 ? 49.642 -19.695 -23.954 1.00 10.90 ? 550 LEU A CA 1 ATOM 4181 C C . LEU A 1 550 ? 48.430 -18.778 -23.992 1.00 10.57 ? 550 LEU A C 1 ATOM 4182 O O . LEU A 1 550 ? 48.452 -17.655 -23.460 1.00 10.57 ? 550 LEU A O 1 ATOM 4183 C CB . LEU A 1 550 ? 49.788 -20.264 -22.536 1.00 11.10 ? 550 LEU A CB 1 ATOM 4184 C CG . LEU A 1 550 ? 51.072 -21.014 -22.199 1.00 11.70 ? 550 LEU A CG 1 ATOM 4185 C CD1 . LEU A 1 550 ? 51.022 -21.528 -20.767 1.00 8.50 ? 550 LEU A CD1 1 ATOM 4186 C CD2 . LEU A 1 550 ? 51.295 -22.166 -23.217 1.00 11.72 ? 550 LEU A CD2 1 ATOM 4187 N N . THR A 1 551 ? 47.367 -19.284 -24.577 1.00 11.38 ? 551 THR A N 1 ATOM 4188 C CA . THR A 1 551 ? 46.098 -18.560 -24.746 1.00 13.28 ? 551 THR A CA 1 ATOM 4189 C C . THR A 1 551 ? 44.898 -19.320 -24.157 1.00 12.18 ? 551 THR A C 1 ATOM 4190 O O . THR A 1 551 ? 44.649 -20.450 -24.544 1.00 11.70 ? 551 THR A O 1 ATOM 4191 C CB . THR A 1 551 ? 45.894 -18.445 -26.272 1.00 13.39 ? 551 THR A CB 1 ATOM 4192 O OG1 . THR A 1 551 ? 46.047 -17.070 -26.633 1.00 20.87 ? 551 THR A OG1 1 ATOM 4193 C CG2 . THR A 1 551 ? 44.479 -18.731 -26.701 1.00 15.15 ? 551 THR A CG2 1 ATOM 4194 N N . MET A 1 552 ? 44.121 -18.687 -23.286 1.00 11.57 ? 552 MET A N 1 ATOM 4195 C CA . MET A 1 552 ? 42.955 -19.348 -22.711 1.00 11.06 ? 552 MET A CA 1 ATOM 4196 C C . MET A 1 552 ? 41.750 -18.397 -22.709 1.00 11.54 ? 552 MET A C 1 ATOM 4197 O O . MET A 1 552 ? 41.810 -17.327 -22.127 1.00 10.58 ? 552 MET A O 1 ATOM 4198 C CB . MET A 1 552 ? 43.247 -19.794 -21.291 1.00 9.96 ? 552 MET A CB 1 ATOM 4199 C CG . MET A 1 552 ? 42.386 -21.013 -20.824 1.00 12.06 ? 552 MET A CG 1 ATOM 4200 S SD . MET A 1 552 ? 40.685 -20.535 -20.413 1.00 17.77 ? 552 MET A SD 1 ATOM 4201 C CE . MET A 1 552 ? 41.010 -19.645 -18.824 1.00 12.24 ? 552 MET A CE 1 ATOM 4202 N N . ALA A 1 553 ? 40.685 -18.786 -23.386 1.00 11.46 ? 553 ALA A N 1 ATOM 4203 C CA . ALA A 1 553 ? 39.419 -18.031 -23.368 1.00 13.53 ? 553 ALA A CA 1 ATOM 4204 C C . ALA A 1 553 ? 38.299 -18.974 -23.800 1.00 13.41 ? 553 ALA A C 1 ATOM 4205 O O . ALA A 1 553 ? 38.560 -19.991 -24.433 1.00 13.04 ? 553 ALA A O 1 ATOM 4206 C CB . ALA A 1 553 ? 39.452 -16.721 -24.243 1.00 12.73 ? 553 ALA A CB 1 ATOM 4207 N N . ASP A 1 554 ? 37.070 -18.684 -23.394 1.00 14.62 ? 554 ASP A N 1 ATOM 4208 C CA . ASP A 1 554 ? 35.964 -19.593 -23.717 1.00 16.01 ? 554 ASP A CA 1 ATOM 4209 C C . ASP A 1 554 ? 36.254 -21.043 -23.391 1.00 15.90 ? 554 ASP A C 1 ATOM 4210 O O . ASP A 1 554 ? 35.852 -21.923 -24.164 1.00 14.01 ? 554 ASP A O 1 ATOM 4211 C CB . ASP A 1 554 ? 35.690 -19.561 -25.205 1.00 17.20 ? 554 ASP A CB 1 ATOM 4212 C CG . ASP A 1 554 ? 34.834 -18.398 -25.600 1.00 21.88 ? 554 ASP A CG 1 ATOM 4213 O OD1 . ASP A 1 554 ? 33.796 -18.631 -26.276 1.00 33.99 ? 554 ASP A OD1 1 ATOM 4214 O OD2 . ASP A 1 554 ? 35.090 -17.249 -25.259 1.00 21.20 ? 554 ASP A OD2 1 ATOM 4215 N N . ARG A 1 555 ? 36.963 -21.292 -22.284 1.00 15.47 ? 555 ARG A N 1 ATOM 4216 C CA . ARG A 1 555 ? 37.269 -22.654 -21.864 1.00 15.98 ? 555 ARG A CA 1 ATOM 4217 C C . ARG A 1 555 ? 38.151 -23.390 -22.870 1.00 15.86 ? 555 ARG A C 1 ATOM 4218 O O . ARG A 1 555 ? 38.365 -24.604 -22.776 1.00 15.91 ? 555 ARG A O 1 ATOM 4219 C CB . ARG A 1 555 ? 35.974 -23.402 -21.574 1.00 17.06 ? 555 ARG A CB 1 ATOM 4220 C CG . ARG A 1 555 ? 35.078 -22.645 -20.540 1.00 21.87 ? 555 ARG A CG 1 ATOM 4221 C CD . ARG A 1 555 ? 33.698 -23.280 -20.301 1.00 28.45 ? 555 ARG A CD 1 ATOM 4222 N NE . ARG A 1 555 ? 33.810 -24.658 -20.762 1.00 39.73 ? 555 ARG A NE 1 ATOM 4223 C CZ . ARG A 1 555 ? 32.819 -25.391 -21.285 1.00 44.12 ? 555 ARG A CZ 1 ATOM 4224 N NH1 . ARG A 1 555 ? 33.066 -26.636 -21.699 1.00 43.29 ? 555 ARG A NH1 1 ATOM 4225 N NH2 . ARG A 1 555 ? 31.584 -24.889 -21.371 1.00 45.95 ? 555 ARG A NH2 1 ATOM 4226 N N . GLN A 1 556 ? 38.724 -22.635 -23.800 1.00 15.69 ? 556 GLN A N 1 ATOM 4227 C CA . GLN A 1 556 ? 39.595 -23.223 -24.813 1.00 16.58 ? 556 GLN A CA 1 ATOM 4228 C C . GLN A 1 556 ? 41.064 -22.773 -24.631 1.00 16.50 ? 556 GLN A C 1 ATOM 4229 O O . GLN A 1 556 ? 41.310 -21.683 -24.101 1.00 16.90 ? 556 GLN A O 1 ATOM 4230 C CB . GLN A 1 556 ? 39.070 -22.865 -26.186 1.00 16.30 ? 556 GLN A CB 1 ATOM 4231 C CG . GLN A 1 556 ? 37.787 -23.642 -26.505 1.00 21.02 ? 556 GLN A CG 1 ATOM 4232 C CD . GLN A 1 556 ? 37.184 -23.244 -27.835 1.00 27.22 ? 556 GLN A CD 1 ATOM 4233 O OE1 . GLN A 1 556 ? 37.461 -22.147 -28.346 1.00 31.77 ? 556 GLN A OE1 1 ATOM 4234 N NE2 . GLN A 1 556 ? 36.347 -24.112 -28.394 1.00 29.18 ? 556 GLN A NE2 1 ATOM 4235 N N . GLY A 1 557 ? 42.013 -23.618 -25.042 1.00 15.23 ? 557 GLY A N 1 ATOM 4236 C CA . GLY A 1 557 ? 43.427 -23.314 -24.897 1.00 14.68 ? 557 GLY A CA 1 ATOM 4237 C C . GLY A 1 557 ? 44.213 -23.533 -26.173 1.00 15.19 ? 557 GLY A C 1 ATOM 4238 O O . GLY A 1 557 ? 43.957 -24.479 -26.921 1.00 14.78 ? 557 GLY A O 1 ATOM 4239 N N . SER A 1 558 ? 45.165 -22.642 -26.431 1.00 13.40 ? 558 SER A N 1 ATOM 4240 C CA . SER A 1 558 ? 46.063 -22.818 -27.559 1.00 12.89 ? 558 SER A CA 1 ATOM 4241 C C . SER A 1 558 ? 47.478 -22.625 -27.052 1.00 12.78 ? 558 SER A C 1 ATOM 4242 O O . SER A 1 558 ? 47.702 -21.840 -26.108 1.00 13.25 ? 558 SER A O 1 ATOM 4243 C CB . SER A 1 558 ? 45.754 -21.815 -28.681 1.00 12.43 ? 558 SER A CB 1 ATOM 4244 O OG . SER A 1 558 ? 44.405 -21.957 -29.115 1.00 13.49 ? 558 SER A OG 1 ATOM 4245 N N . VAL A 1 559 ? 48.441 -23.274 -27.687 1.00 12.23 ? 559 VAL A N 1 ATOM 4246 C CA . VAL A 1 559 ? 49.830 -23.035 -27.341 1.00 12.14 ? 559 VAL A CA 1 ATOM 4247 C C . VAL A 1 559 ? 50.560 -22.652 -28.611 1.00 11.70 ? 559 VAL A C 1 ATOM 4248 O O . VAL A 1 559 ? 50.470 -23.352 -29.606 1.00 11.72 ? 559 VAL A O 1 ATOM 4249 C CB . VAL A 1 559 ? 50.469 -24.296 -26.758 1.00 11.89 ? 559 VAL A CB 1 ATOM 4250 C CG1 . VAL A 1 559 ? 51.933 -24.058 -26.404 1.00 11.33 ? 559 VAL A CG1 1 ATOM 4251 C CG2 . VAL A 1 559 ? 49.686 -24.765 -25.557 1.00 10.61 ? 559 VAL A CG2 1 ATOM 4252 N N . TYR A 1 560 ? 51.288 -21.551 -28.567 1.00 11.33 ? 560 TYR A N 1 ATOM 4253 C CA . TYR A 1 560 ? 52.035 -21.081 -29.732 1.00 11.43 ? 560 TYR A CA 1 ATOM 4254 C C . TYR A 1 560 ? 53.515 -21.130 -29.494 1.00 11.30 ? 560 TYR A C 1 ATOM 4255 O O . TYR A 1 560 ? 53.973 -20.736 -28.445 1.00 9.81 ? 560 TYR A O 1 ATOM 4256 C CB . TYR A 1 560 ? 51.715 -19.619 -30.002 1.00 10.76 ? 560 TYR A CB 1 ATOM 4257 C CG . TYR A 1 560 ? 50.291 -19.355 -30.393 1.00 11.81 ? 560 TYR A CG 1 ATOM 4258 C CD1 . TYR A 1 560 ? 49.311 -19.281 -29.442 1.00 10.08 ? 560 TYR A CD1 1 ATOM 4259 C CD2 . TYR A 1 560 ? 49.933 -19.188 -31.733 1.00 12.63 ? 560 TYR A CD2 1 ATOM 4260 C CE1 . TYR A 1 560 ? 48.007 -19.038 -29.785 1.00 10.74 ? 560 TYR A CE1 1 ATOM 4261 C CE2 . TYR A 1 560 ? 48.611 -18.931 -32.097 1.00 14.40 ? 560 TYR A CE2 1 ATOM 4262 C CZ . TYR A 1 560 ? 47.654 -18.872 -31.103 1.00 13.55 ? 560 TYR A CZ 1 ATOM 4263 O OH . TYR A 1 560 ? 46.355 -18.648 -31.403 1.00 13.36 ? 560 TYR A OH 1 ATOM 4264 N N . VAL A 1 561 ? 54.257 -21.586 -30.493 1.00 11.81 ? 561 VAL A N 1 ATOM 4265 C CA . VAL A 1 561 ? 55.701 -21.471 -30.478 1.00 13.09 ? 561 VAL A CA 1 ATOM 4266 C C . VAL A 1 561 ? 56.117 -20.648 -31.705 1.00 14.05 ? 561 VAL A C 1 ATOM 4267 O O . VAL A 1 561 ? 55.676 -20.930 -32.792 1.00 14.94 ? 561 VAL A O 1 ATOM 4268 C CB . VAL A 1 561 ? 56.367 -22.841 -30.544 1.00 13.04 ? 561 VAL A CB 1 ATOM 4269 C CG1 . VAL A 1 561 ? 57.877 -22.680 -30.661 1.00 12.64 ? 561 VAL A CG1 1 ATOM 4270 C CG2 . VAL A 1 561 ? 56.002 -23.671 -29.310 1.00 12.16 ? 561 VAL A CG2 1 ATOM 4271 N N . ASP A 1 562 ? 56.963 -19.633 -31.551 1.00 14.75 ? 562 ASP A N 1 ATOM 4272 C CA . ASP A 1 562 ? 57.347 -18.837 -32.720 1.00 14.73 ? 562 ASP A CA 1 ATOM 4273 C C . ASP A 1 562 ? 56.128 -18.346 -33.526 1.00 14.56 ? 562 ASP A C 1 ATOM 4274 O O . ASP A 1 562 ? 56.141 -18.319 -34.744 1.00 14.59 ? 562 ASP A O 1 ATOM 4275 C CB . ASP A 1 562 ? 58.408 -19.552 -33.602 1.00 14.52 ? 562 ASP A CB 1 ATOM 4276 C CG . ASP A 1 562 ? 59.744 -19.691 -32.874 1.00 16.65 ? 562 ASP A CG 1 ATOM 4277 O OD1 . ASP A 1 562 ? 59.905 -19.004 -31.825 1.00 17.44 ? 562 ASP A OD1 1 ATOM 4278 O OD2 . ASP A 1 562 ? 60.665 -20.474 -33.206 1.00 17.93 ? 562 ASP A OD2 1 ATOM 4279 N N . GLY A 1 563 ? 55.060 -17.989 -32.821 1.00 14.71 ? 563 GLY A N 1 ATOM 4280 C CA . GLY A 1 563 ? 53.950 -17.284 -33.428 1.00 13.57 ? 563 GLY A CA 1 ATOM 4281 C C . GLY A 1 563 ? 53.037 -18.185 -34.198 1.00 14.28 ? 563 GLY A C 1 ATOM 4282 O O . GLY A 1 563 ? 52.096 -17.696 -34.804 1.00 13.54 ? 563 GLY A O 1 ATOM 4283 N N . GLN A 1 564 ? 53.286 -19.499 -34.134 1.00 14.52 ? 564 GLN A N 1 ATOM 4284 C CA . GLN A 1 564 ? 52.435 -20.473 -34.811 1.00 15.01 ? 564 GLN A CA 1 ATOM 4285 C C . GLN A 1 564 ? 51.869 -21.434 -33.770 1.00 15.63 ? 564 GLN A C 1 ATOM 4286 O O . GLN A 1 564 ? 52.570 -21.862 -32.849 1.00 15.53 ? 564 GLN A O 1 ATOM 4287 C CB . GLN A 1 564 ? 53.219 -21.262 -35.884 1.00 15.30 ? 564 GLN A CB 1 ATOM 4288 C CG . GLN A 1 564 ? 53.852 -20.405 -37.002 1.00 18.89 ? 564 GLN A CG 1 ATOM 4289 C CD . GLN A 1 564 ? 52.831 -19.501 -37.722 1.00 22.67 ? 564 GLN A CD 1 ATOM 4290 O OE1 . GLN A 1 564 ? 51.729 -19.937 -38.065 1.00 22.83 ? 564 GLN A OE1 1 ATOM 4291 N NE2 . GLN A 1 564 ? 53.208 -18.250 -37.953 1.00 22.21 ? 564 GLN A NE2 1 ATOM 4292 N N . PRO A 1 565 ? 50.607 -21.807 -33.920 1.00 15.88 ? 565 PRO A N 1 ATOM 4293 C CA . PRO A 1 565 ? 49.971 -22.684 -32.937 1.00 16.27 ? 565 PRO A CA 1 ATOM 4294 C C . PRO A 1 565 ? 50.454 -24.124 -33.097 1.00 16.49 ? 565 PRO A C 1 ATOM 4295 O O . PRO A 1 565 ? 50.713 -24.577 -34.217 1.00 17.50 ? 565 PRO A O 1 ATOM 4296 C CB . PRO A 1 565 ? 48.473 -22.612 -33.316 1.00 17.03 ? 565 PRO A CB 1 ATOM 4297 C CG . PRO A 1 565 ? 48.449 -22.321 -34.799 1.00 16.12 ? 565 PRO A CG 1 ATOM 4298 C CD . PRO A 1 565 ? 49.712 -21.465 -35.046 1.00 16.47 ? 565 PRO A CD 1 ATOM 4299 N N . LEU A 1 566 ? 50.566 -24.849 -32.003 1.00 15.14 ? 566 LEU A N 1 ATOM 4300 C CA . LEU A 1 566 ? 50.927 -26.237 -32.109 1.00 14.99 ? 566 LEU A CA 1 ATOM 4301 C C . LEU A 1 566 ? 49.664 -27.101 -32.248 1.00 16.09 ? 566 LEU A C 1 ATOM 4302 O O . LEU A 1 566 ? 48.597 -26.699 -31.836 1.00 15.49 ? 566 LEU A O 1 ATOM 4303 C CB . LEU A 1 566 ? 51.637 -26.658 -30.833 1.00 15.20 ? 566 LEU A CB 1 ATOM 4304 C CG . LEU A 1 566 ? 52.878 -25.866 -30.385 1.00 13.20 ? 566 LEU A CG 1 ATOM 4305 C CD1 . LEU A 1 566 ? 53.371 -26.574 -29.125 1.00 11.12 ? 566 LEU A CD1 1 ATOM 4306 C CD2 . LEU A 1 566 ? 53.931 -25.891 -31.498 1.00 9.59 ? 566 LEU A CD2 1 ATOM 4307 N N . ALA A 1 567 ? 49.804 -28.304 -32.800 1.00 17.11 ? 567 ALA A N 1 ATOM 4308 C CA . ALA A 1 567 ? 48.695 -29.264 -32.871 1.00 18.39 ? 567 ALA A CA 1 ATOM 4309 C C . ALA A 1 567 ? 47.894 -29.393 -31.527 1.00 19.23 ? 567 ALA A C 1 ATOM 4310 O O . ALA A 1 567 ? 48.464 -29.331 -30.404 1.00 18.39 ? 567 ALA A O 1 ATOM 4311 C CB . ALA A 1 567 ? 49.219 -30.630 -33.308 1.00 17.52 ? 567 ALA A CB 1 ATOM 4312 N N . GLY A 1 568 ? 46.581 -29.581 -31.649 1.00 18.84 ? 568 GLY A N 1 ATOM 4313 C CA . GLY A 1 568 ? 45.732 -29.676 -30.474 1.00 19.11 ? 568 GLY A CA 1 ATOM 4314 C C . GLY A 1 568 ? 45.238 -28.322 -29.997 1.00 19.54 ? 568 GLY A C 1 ATOM 4315 O O . GLY A 1 568 ? 44.369 -28.225 -29.118 1.00 20.35 ? 568 GLY A O 1 ATOM 4316 N N . SER A 1 569 ? 45.734 -27.258 -30.604 1.00 19.70 ? 569 SER A N 1 ATOM 4317 C CA . SER A 1 569 ? 45.338 -25.925 -30.157 1.00 19.94 ? 569 SER A CA 1 ATOM 4318 C C . SER A 1 569 ? 43.890 -25.670 -30.472 1.00 20.50 ? 569 SER A C 1 ATOM 4319 O O . SER A 1 569 ? 43.381 -26.198 -31.455 1.00 19.63 ? 569 SER A O 1 ATOM 4320 C CB . SER A 1 569 ? 46.269 -24.841 -30.706 1.00 20.25 ? 569 SER A CB 1 ATOM 4321 O OG . SER A 1 569 ? 47.429 -24.777 -29.871 1.00 18.00 ? 569 SER A OG 1 ATOM 4322 N N . GLY A 1 570 ? 43.220 -24.887 -29.625 1.00 20.95 ? 570 GLY A N 1 ATOM 4323 C CA . GLY A 1 570 ? 41.780 -24.692 -29.776 1.00 21.98 ? 570 GLY A CA 1 ATOM 4324 C C . GLY A 1 570 ? 41.025 -25.764 -28.984 1.00 22.53 ? 570 GLY A C 1 ATOM 4325 O O . GLY A 1 570 ? 39.831 -25.687 -28.807 1.00 23.08 ? 570 GLY A O 1 ATOM 4326 N N . ASN A 1 571 ? 41.719 -26.770 -28.479 1.00 23.40 ? 571 ASN A N 1 ATOM 4327 C CA . ASN A 1 571 ? 41.029 -27.756 -27.635 1.00 24.93 ? 571 ASN A CA 1 ATOM 4328 C C . ASN A 1 571 ? 40.442 -27.197 -26.310 1.00 24.62 ? 571 ASN A C 1 ATOM 4329 O O . ASN A 1 571 ? 41.005 -26.308 -25.681 1.00 24.17 ? 571 ASN A O 1 ATOM 4330 C CB . ASN A 1 571 ? 41.913 -28.984 -27.350 1.00 26.08 ? 571 ASN A CB 1 ATOM 4331 C CG . ASN A 1 571 ? 42.082 -29.908 -28.573 1.00 29.43 ? 571 ASN A CG 1 ATOM 4332 O OD1 . ASN A 1 571 ? 41.447 -29.713 -29.634 1.00 32.48 ? 571 ASN A OD1 1 ATOM 4333 N ND2 . ASN A 1 571 ? 42.970 -30.888 -28.439 1.00 29.00 ? 571 ASN A ND2 1 ATOM 4334 N N . THR A 1 572 ? 39.294 -27.744 -25.922 1.00 24.50 ? 572 THR A N 1 ATOM 4335 C CA . THR A 1 572 ? 38.598 -27.418 -24.685 1.00 24.05 ? 572 THR A CA 1 ATOM 4336 C C . THR A 1 572 ? 39.476 -27.780 -23.505 1.00 23.68 ? 572 THR A C 1 ATOM 4337 O O . THR A 1 572 ? 39.995 -28.882 -23.456 1.00 23.97 ? 572 THR A O 1 ATOM 4338 C CB . THR A 1 572 ? 37.278 -28.209 -24.608 1.00 24.28 ? 572 THR A CB 1 ATOM 4339 O OG1 . THR A 1 572 ? 36.305 -27.607 -25.489 1.00 25.69 ? 572 THR A OG1 1 ATOM 4340 C CG2 . THR A 1 572 ? 36.624 -28.011 -23.230 1.00 24.91 ? 572 THR A CG2 1 ATOM 4341 N N . VAL A 1 573 ? 39.664 -26.864 -22.559 1.00 22.44 ? 573 VAL A N 1 ATOM 4342 C CA . VAL A 1 573 ? 40.541 -27.158 -21.455 1.00 21.43 ? 573 VAL A CA 1 ATOM 4343 C C . VAL A 1 573 ? 39.781 -27.387 -20.174 1.00 22.83 ? 573 VAL A C 1 ATOM 4344 O O . VAL A 1 573 ? 40.295 -28.006 -19.258 1.00 21.68 ? 573 VAL A O 1 ATOM 4345 C CB . VAL A 1 573 ? 41.591 -26.053 -21.251 1.00 22.09 ? 573 VAL A CB 1 ATOM 4346 C CG1 . VAL A 1 573 ? 42.454 -25.908 -22.494 1.00 19.82 ? 573 VAL A CG1 1 ATOM 4347 C CG2 . VAL A 1 573 ? 40.934 -24.710 -20.837 1.00 18.07 ? 573 VAL A CG2 1 ATOM 4348 N N . VAL A 1 574 ? 38.557 -26.885 -20.082 1.00 24.12 ? 574 VAL A N 1 ATOM 4349 C CA . VAL A 1 574 ? 37.789 -27.201 -18.894 1.00 26.59 ? 574 VAL A CA 1 ATOM 4350 C C . VAL A 1 574 ? 36.341 -27.544 -19.254 1.00 28.60 ? 574 VAL A C 1 ATOM 4351 O O . VAL A 1 574 ? 35.792 -27.000 -20.201 1.00 28.28 ? 574 VAL A O 1 ATOM 4352 C CB . VAL A 1 574 ? 37.824 -26.048 -17.884 1.00 26.54 ? 574 VAL A CB 1 ATOM 4353 C CG1 . VAL A 1 574 ? 37.150 -24.837 -18.459 1.00 24.69 ? 574 VAL A CG1 1 ATOM 4354 C CG2 . VAL A 1 574 ? 37.153 -26.459 -16.563 1.00 26.69 ? 574 VAL A CG2 1 ATOM 4355 N N . ARG A 1 575 ? 35.716 -28.449 -18.510 1.00 31.51 ? 575 ARG A N 1 ATOM 4356 C CA . ARG A 1 575 ? 34.301 -28.774 -18.779 1.00 34.49 ? 575 ARG A CA 1 ATOM 4357 C C . ARG A 1 575 ? 33.370 -28.273 -17.678 1.00 35.08 ? 575 ARG A C 1 ATOM 4358 O O . ARG A 1 575 ? 33.747 -28.252 -16.511 1.00 35.38 ? 575 ARG A O 1 ATOM 4359 C CB . ARG A 1 575 ? 34.105 -30.286 -18.978 1.00 35.48 ? 575 ARG A CB 1 ATOM 4360 C CG . ARG A 1 575 ? 33.783 -30.727 -20.404 1.00 38.63 ? 575 ARG A CG 1 ATOM 4361 C CD . ARG A 1 575 ? 34.945 -30.550 -21.360 1.00 45.39 ? 575 ARG A CD 1 ATOM 4362 N NE . ARG A 1 575 ? 34.807 -31.289 -22.619 1.00 49.01 ? 575 ARG A NE 1 ATOM 4363 C CZ . ARG A 1 575 ? 35.775 -32.035 -23.141 1.00 51.17 ? 575 ARG A CZ 1 ATOM 4364 N NH1 . ARG A 1 575 ? 36.943 -32.154 -22.508 1.00 51.87 ? 575 ARG A NH1 1 ATOM 4365 N NH2 . ARG A 1 575 ? 35.578 -32.659 -24.294 1.00 51.98 ? 575 ARG A NH2 1 ATOM 4366 N N . GLY A 1 576 ? 32.160 -27.861 -18.053 1.00 36.11 ? 576 GLY A N 1 ATOM 4367 C CA . GLY A 1 576 ? 31.177 -27.418 -17.075 1.00 36.56 ? 576 GLY A CA 1 ATOM 4368 C C . GLY A 1 576 ? 31.065 -25.913 -16.823 1.00 37.29 ? 576 GLY A C 1 ATOM 4369 O O . GLY A 1 576 ? 31.761 -25.101 -17.431 1.00 37.66 ? 576 GLY A O 1 ATOM 4370 N N . ALA A 1 577 ? 30.184 -25.546 -15.897 1.00 37.30 ? 577 ALA A N 1 ATOM 4371 C CA . ALA A 1 577 ? 29.912 -24.138 -15.587 1.00 36.97 ? 577 ALA A CA 1 ATOM 4372 C C . ALA A 1 577 ? 30.818 -23.539 -14.501 1.00 36.22 ? 577 ALA A C 1 ATOM 4373 O O . ALA A 1 577 ? 30.928 -22.304 -14.371 1.00 36.13 ? 577 ALA A O 1 ATOM 4374 C CB . ALA A 1 577 ? 28.447 -23.961 -15.201 1.00 37.04 ? 577 ALA A CB 1 ATOM 4375 N N . THR A 1 578 ? 31.439 -24.417 -13.709 1.00 34.36 ? 578 THR A N 1 ATOM 4376 C CA . THR A 1 578 ? 32.319 -23.969 -12.646 1.00 32.38 ? 578 THR A CA 1 ATOM 4377 C C . THR A 1 578 ? 33.637 -23.438 -13.186 1.00 29.49 ? 578 THR A C 1 ATOM 4378 O O . THR A 1 578 ? 34.352 -24.140 -13.909 1.00 28.79 ? 578 THR A O 1 ATOM 4379 C CB . THR A 1 578 ? 32.620 -25.136 -11.714 1.00 32.94 ? 578 THR A CB 1 ATOM 4380 O OG1 . THR A 1 578 ? 31.405 -25.569 -11.095 1.00 35.32 ? 578 THR A OG1 1 ATOM 4381 C CG2 . THR A 1 578 ? 33.467 -24.673 -10.521 1.00 33.99 ? 578 THR A CG2 1 ATOM 4382 N N . LEU A 1 579 ? 33.948 -22.200 -12.841 1.00 26.40 ? 579 LEU A N 1 ATOM 4383 C CA . LEU A 1 579 ? 35.253 -21.633 -13.170 1.00 24.04 ? 579 LEU A CA 1 ATOM 4384 C C . LEU A 1 579 ? 36.417 -22.486 -12.673 1.00 21.61 ? 579 LEU A C 1 ATOM 4385 O O . LEU A 1 579 ? 36.414 -23.002 -11.590 1.00 21.33 ? 579 LEU A O 1 ATOM 4386 C CB . LEU A 1 579 ? 35.425 -20.290 -12.495 1.00 24.22 ? 579 LEU A CB 1 ATOM 4387 C CG . LEU A 1 579 ? 34.974 -19.018 -13.193 1.00 24.66 ? 579 LEU A CG 1 ATOM 4388 C CD1 . LEU A 1 579 ? 35.516 -17.845 -12.356 1.00 25.24 ? 579 LEU A CD1 1 ATOM 4389 C CD2 . LEU A 1 579 ? 35.479 -18.959 -14.595 1.00 20.27 ? 579 LEU A CD2 1 ATOM 4390 N N . PRO A 1 580 ? 37.426 -22.630 -13.493 1.00 19.82 ? 580 PRO A N 1 ATOM 4391 C CA . PRO A 1 580 ? 38.659 -23.253 -13.043 1.00 18.46 ? 580 PRO A CA 1 ATOM 4392 C C . PRO A 1 580 ? 39.164 -22.507 -11.810 1.00 17.52 ? 580 PRO A C 1 ATOM 4393 O O . PRO A 1 580 ? 38.760 -21.371 -11.545 1.00 16.27 ? 580 PRO A O 1 ATOM 4394 C CB . PRO A 1 580 ? 39.603 -22.987 -14.202 1.00 18.04 ? 580 PRO A CB 1 ATOM 4395 C CG . PRO A 1 580 ? 38.750 -22.833 -15.353 1.00 19.17 ? 580 PRO A CG 1 ATOM 4396 C CD . PRO A 1 580 ? 37.457 -22.248 -14.906 1.00 18.71 ? 580 PRO A CD 1 ATOM 4397 N N . ASP A 1 581 ? 40.046 -23.159 -11.065 1.00 16.26 ? 581 ASP A N 1 ATOM 4398 C CA . ASP A 1 581 ? 40.668 -22.564 -9.892 1.00 15.62 ? 581 ASP A CA 1 ATOM 4399 C C . ASP A 1 581 ? 42.195 -22.714 -10.016 1.00 14.55 ? 581 ASP A C 1 ATOM 4400 O O . ASP A 1 581 ? 42.818 -23.591 -9.403 1.00 13.82 ? 581 ASP A O 1 ATOM 4401 C CB . ASP A 1 581 ? 40.143 -23.246 -8.626 1.00 16.25 ? 581 ASP A CB 1 ATOM 4402 C CG . ASP A 1 581 ? 40.588 -22.549 -7.324 1.00 18.20 ? 581 ASP A CG 1 ATOM 4403 O OD1 . ASP A 1 581 ? 41.127 -21.419 -7.386 1.00 15.83 ? 581 ASP A OD1 1 ATOM 4404 O OD2 . ASP A 1 581 ? 40.426 -23.086 -6.186 1.00 16.73 ? 581 ASP A OD2 1 ATOM 4405 N N . ILE A 1 582 ? 42.788 -21.862 -10.831 1.00 12.52 ? 582 ILE A N 1 ATOM 4406 C CA . ILE A 1 582 ? 44.227 -21.881 -11.025 1.00 11.06 ? 582 ILE A CA 1 ATOM 4407 C C . ILE A 1 582 ? 44.973 -21.519 -9.751 1.00 10.86 ? 582 ILE A C 1 ATOM 4408 O O . ILE A 1 582 ? 44.674 -20.516 -9.113 1.00 11.35 ? 582 ILE A O 1 ATOM 4409 C CB . ILE A 1 582 ? 44.597 -20.884 -12.101 1.00 10.45 ? 582 ILE A CB 1 ATOM 4410 C CG1 . ILE A 1 582 ? 43.872 -21.253 -13.388 1.00 9.23 ? 582 ILE A CG1 1 ATOM 4411 C CG2 . ILE A 1 582 ? 46.094 -20.865 -12.304 1.00 8.32 ? 582 ILE A CG2 1 ATOM 4412 C CD1 . ILE A 1 582 ? 44.073 -20.280 -14.555 1.00 7.33 ? 582 ILE A CD1 1 ATOM 4413 N N . SER A 1 583 ? 45.944 -22.344 -9.397 1.00 10.17 ? 583 SER A N 1 ATOM 4414 C CA . SER A 1 583 ? 46.778 -22.133 -8.215 1.00 10.87 ? 583 SER A CA 1 ATOM 4415 C C . SER A 1 583 ? 47.932 -21.181 -8.511 1.00 9.92 ? 583 SER A C 1 ATOM 4416 O O . SER A 1 583 ? 48.242 -20.318 -7.688 1.00 10.75 ? 583 SER A O 1 ATOM 4417 C CB . SER A 1 583 ? 47.379 -23.465 -7.737 1.00 10.10 ? 583 SER A CB 1 ATOM 4418 O OG . SER A 1 583 ? 47.983 -24.154 -8.847 1.00 13.00 ? 583 SER A OG 1 ATOM 4419 N N . HIS A 1 584 ? 48.556 -21.333 -9.675 1.00 9.33 ? 584 HIS A N 1 ATOM 4420 C CA . HIS A 1 584 ? 49.712 -20.489 -10.051 1.00 9.10 ? 584 HIS A CA 1 ATOM 4421 C C . HIS A 1 584 ? 50.087 -20.688 -11.496 1.00 8.62 ? 584 HIS A C 1 ATOM 4422 O O . HIS A 1 584 ? 49.576 -21.581 -12.159 1.00 9.59 ? 584 HIS A O 1 ATOM 4423 C CB . HIS A 1 584 ? 50.938 -20.859 -9.201 1.00 8.83 ? 584 HIS A CB 1 ATOM 4424 C CG . HIS A 1 584 ? 51.438 -22.260 -9.430 1.00 11.67 ? 584 HIS A CG 1 ATOM 4425 N ND1 . HIS A 1 584 ? 50.707 -23.383 -9.089 1.00 12.46 ? 584 HIS A ND1 1 ATOM 4426 C CD2 . HIS A 1 584 ? 52.602 -22.721 -9.959 1.00 13.68 ? 584 HIS A CD2 1 ATOM 4427 C CE1 . HIS A 1 584 ? 51.395 -24.471 -9.404 1.00 13.30 ? 584 HIS A CE1 1 ATOM 4428 N NE2 . HIS A 1 584 ? 52.548 -24.096 -9.931 1.00 12.16 ? 584 HIS A NE2 1 ATOM 4429 N N . PHE A 1 585 ? 50.980 -19.849 -11.999 1.00 8.72 ? 585 PHE A N 1 ATOM 4430 C CA . PHE A 1 585 ? 51.603 -20.121 -13.272 1.00 8.14 ? 585 PHE A CA 1 ATOM 4431 C C . PHE A 1 585 ? 52.964 -20.637 -12.873 1.00 8.82 ? 585 PHE A C 1 ATOM 4432 O O . PHE A 1 585 ? 53.571 -20.115 -11.930 1.00 9.06 ? 585 PHE A O 1 ATOM 4433 C CB . PHE A 1 585 ? 51.775 -18.849 -14.079 1.00 7.80 ? 585 PHE A CB 1 ATOM 4434 C CG . PHE A 1 585 ? 50.484 -18.203 -14.456 1.00 7.61 ? 585 PHE A CG 1 ATOM 4435 C CD1 . PHE A 1 585 ? 50.072 -17.048 -13.825 1.00 6.80 ? 585 PHE A CD1 1 ATOM 4436 C CD2 . PHE A 1 585 ? 49.689 -18.754 -15.454 1.00 5.68 ? 585 PHE A CD2 1 ATOM 4437 C CE1 . PHE A 1 585 ? 48.877 -16.457 -14.172 1.00 8.42 ? 585 PHE A CE1 1 ATOM 4438 C CE2 . PHE A 1 585 ? 48.504 -18.170 -15.814 1.00 8.40 ? 585 PHE A CE2 1 ATOM 4439 C CZ . PHE A 1 585 ? 48.077 -17.024 -15.171 1.00 6.53 ? 585 PHE A CZ 1 ATOM 4440 N N . TYR A 1 586 ? 53.459 -21.650 -13.565 1.00 8.11 ? 586 TYR A N 1 ATOM 4441 C CA . TYR A 1 586 ? 54.791 -22.115 -13.309 1.00 9.20 ? 586 TYR A CA 1 ATOM 4442 C C . TYR A 1 586 ? 55.643 -21.807 -14.517 1.00 9.51 ? 586 TYR A C 1 ATOM 4443 O O . TYR A 1 586 ? 55.144 -21.801 -15.620 1.00 8.78 ? 586 TYR A O 1 ATOM 4444 C CB . TYR A 1 586 ? 54.823 -23.606 -13.021 1.00 9.44 ? 586 TYR A CB 1 ATOM 4445 C CG . TYR A 1 586 ? 54.162 -24.467 -14.063 1.00 9.07 ? 586 TYR A CG 1 ATOM 4446 C CD1 . TYR A 1 586 ? 54.913 -25.039 -15.107 1.00 9.25 ? 586 TYR A CD1 1 ATOM 4447 C CD2 . TYR A 1 586 ? 52.812 -24.718 -14.011 1.00 6.28 ? 586 TYR A CD2 1 ATOM 4448 C CE1 . TYR A 1 586 ? 54.298 -25.835 -16.063 1.00 9.15 ? 586 TYR A CE1 1 ATOM 4449 C CE2 . TYR A 1 586 ? 52.193 -25.511 -14.962 1.00 10.15 ? 586 TYR A CE2 1 ATOM 4450 C CZ . TYR A 1 586 ? 52.955 -26.082 -15.967 1.00 10.53 ? 586 TYR A CZ 1 ATOM 4451 O OH . TYR A 1 586 ? 52.350 -26.857 -16.912 1.00 14.57 ? 586 TYR A OH 1 ATOM 4452 N N . ILE A 1 587 ? 56.919 -21.507 -14.252 1.00 9.54 ? 587 ILE A N 1 ATOM 4453 C CA . ILE A 1 587 ? 57.923 -21.195 -15.232 1.00 9.51 ? 587 ILE A CA 1 ATOM 4454 C C . ILE A 1 587 ? 59.082 -22.095 -14.829 1.00 10.40 ? 587 ILE A C 1 ATOM 4455 O O . ILE A 1 587 ? 59.564 -21.990 -13.688 1.00 10.45 ? 587 ILE A O 1 ATOM 4456 C CB . ILE A 1 587 ? 58.364 -19.727 -15.095 1.00 9.64 ? 587 ILE A CB 1 ATOM 4457 C CG1 . ILE A 1 587 ? 57.170 -18.786 -15.202 1.00 10.73 ? 587 ILE A CG1 1 ATOM 4458 C CG2 . ILE A 1 587 ? 59.412 -19.405 -16.154 1.00 9.33 ? 587 ILE A CG2 1 ATOM 4459 C CD1 . ILE A 1 587 ? 57.288 -17.471 -14.362 1.00 10.03 ? 587 ILE A CD1 1 ATOM 4460 N N . GLY A 1 588 ? 59.521 -22.975 -15.743 1.00 10.40 ? 588 GLY A N 1 ATOM 4461 C CA . GLY A 1 588 ? 60.500 -23.996 -15.421 1.00 10.59 ? 588 GLY A CA 1 ATOM 4462 C C . GLY A 1 588 ? 59.763 -25.110 -14.734 1.00 11.33 ? 588 GLY A C 1 ATOM 4463 O O . GLY A 1 588 ? 58.607 -25.364 -15.062 1.00 10.40 ? 588 GLY A O 1 ATOM 4464 N N . GLY A 1 589 ? 60.400 -25.774 -13.772 1.00 11.14 ? 589 GLY A N 1 ATOM 4465 C CA . GLY A 1 589 ? 59.710 -26.807 -13.026 1.00 10.48 ? 589 GLY A CA 1 ATOM 4466 C C . GLY A 1 589 ? 59.778 -26.621 -11.521 1.00 11.23 ? 589 GLY A C 1 ATOM 4467 O O . GLY A 1 589 ? 60.408 -27.400 -10.848 1.00 11.58 ? 589 GLY A O 1 ATOM 4468 N N . PRO A 1 590 ? 59.092 -25.628 -10.972 1.00 11.27 ? 590 PRO A N 1 ATOM 4469 C CA . PRO A 1 590 ? 59.158 -25.360 -9.515 1.00 12.36 ? 590 PRO A CA 1 ATOM 4470 C C . PRO A 1 590 ? 58.617 -26.485 -8.598 1.00 12.34 ? 590 PRO A C 1 ATOM 4471 O O . PRO A 1 590 ? 57.692 -27.072 -9.150 1.00 13.79 ? 590 PRO A O 1 ATOM 4472 C CB . PRO A 1 590 ? 58.324 -24.092 -9.336 1.00 11.99 ? 590 PRO A CB 1 ATOM 4473 C CG . PRO A 1 590 ? 57.423 -24.034 -10.570 1.00 12.63 ? 590 PRO A CG 1 ATOM 4474 C CD . PRO A 1 590 ? 58.176 -24.743 -11.705 1.00 11.08 ? 590 PRO A CD 1 ATOM 4475 N N . GLY A 1 594 ? 56.814 -33.128 -4.725 1.00 33.02 ? 594 GLY A N 1 ATOM 4476 C CA . GLY A 1 594 ? 56.882 -34.569 -4.920 1.00 32.85 ? 594 GLY A CA 1 ATOM 4477 C C . GLY A 1 594 ? 58.011 -35.053 -5.828 1.00 32.55 ? 594 GLY A C 1 ATOM 4478 O O . GLY A 1 594 ? 59.144 -35.227 -5.404 1.00 33.38 ? 594 GLY A O 1 ATOM 4479 N N . ALA A 1 595 ? 57.715 -35.274 -7.096 1.00 32.15 ? 595 ALA A N 1 ATOM 4480 C CA . ALA A 1 595 ? 58.740 -35.699 -8.019 1.00 31.55 ? 595 ALA A CA 1 ATOM 4481 C C . ALA A 1 595 ? 59.884 -34.661 -8.044 1.00 31.43 ? 595 ALA A C 1 ATOM 4482 O O . ALA A 1 595 ? 59.672 -33.446 -7.876 1.00 30.73 ? 595 ALA A O 1 ATOM 4483 C CB . ALA A 1 595 ? 58.149 -35.908 -9.428 1.00 32.08 ? 595 ALA A CB 1 ATOM 4484 N N . PRO A 1 596 ? 61.104 -35.154 -8.230 1.00 30.14 ? 596 PRO A N 1 ATOM 4485 C CA . PRO A 1 596 ? 62.278 -34.295 -8.203 1.00 29.47 ? 596 PRO A CA 1 ATOM 4486 C C . PRO A 1 596 ? 62.533 -33.541 -9.503 1.00 27.99 ? 596 PRO A C 1 ATOM 4487 O O . PRO A 1 596 ? 63.690 -33.445 -9.955 1.00 28.58 ? 596 PRO A O 1 ATOM 4488 C CB . PRO A 1 596 ? 63.392 -35.307 -7.926 1.00 29.67 ? 596 PRO A CB 1 ATOM 4489 C CG . PRO A 1 596 ? 62.967 -36.440 -8.774 1.00 30.20 ? 596 PRO A CG 1 ATOM 4490 C CD . PRO A 1 596 ? 61.485 -36.572 -8.378 1.00 30.27 ? 596 PRO A CD 1 ATOM 4491 N N . THR A 1 597 ? 61.491 -32.972 -10.081 1.00 24.92 ? 597 THR A N 1 ATOM 4492 C CA . THR A 1 597 ? 61.649 -32.258 -11.345 1.00 22.24 ? 597 THR A CA 1 ATOM 4493 C C . THR A 1 597 ? 62.902 -31.337 -11.416 1.00 20.57 ? 597 THR A C 1 ATOM 4494 O O . THR A 1 597 ? 63.177 -30.600 -10.494 1.00 20.62 ? 597 THR A O 1 ATOM 4495 C CB . THR A 1 597 ? 60.352 -31.468 -11.578 1.00 22.96 ? 597 THR A CB 1 ATOM 4496 O OG1 . THR A 1 597 ? 59.235 -32.373 -11.444 1.00 23.33 ? 597 THR A OG1 1 ATOM 4497 C CG2 . THR A 1 597 ? 60.260 -30.953 -12.996 1.00 18.35 ? 597 THR A CG2 1 ATOM 4498 N N . ASP A 1 598 ? 63.651 -31.394 -12.514 1.00 18.67 ? 598 ASP A N 1 ATOM 4499 C CA . ASP A 1 598 ? 64.800 -30.504 -12.736 1.00 17.15 ? 598 ASP A CA 1 ATOM 4500 C C . ASP A 1 598 ? 64.853 -30.089 -14.199 1.00 15.23 ? 598 ASP A C 1 ATOM 4501 O O . ASP A 1 598 ? 65.573 -30.670 -15.008 1.00 14.07 ? 598 ASP A O 1 ATOM 4502 C CB . ASP A 1 598 ? 66.126 -31.156 -12.325 1.00 17.48 ? 598 ASP A CB 1 ATOM 4503 C CG . ASP A 1 598 ? 67.307 -30.183 -12.388 1.00 17.31 ? 598 ASP A CG 1 ATOM 4504 O OD1 . ASP A 1 598 ? 67.171 -29.089 -12.980 1.00 16.07 ? 598 ASP A OD1 1 ATOM 4505 O OD2 . ASP A 1 598 ? 68.413 -30.417 -11.857 1.00 17.99 ? 598 ASP A OD2 1 ATOM 4506 N N . SER A 1 599 ? 64.041 -29.096 -14.532 1.00 14.11 ? 599 SER A N 1 ATOM 4507 C CA . SER A 1 599 ? 63.935 -28.595 -15.889 1.00 12.89 ? 599 SER A CA 1 ATOM 4508 C C . SER A 1 599 ? 65.075 -27.629 -16.179 1.00 11.82 ? 599 SER A C 1 ATOM 4509 O O . SER A 1 599 ? 65.158 -26.552 -15.574 1.00 10.17 ? 599 SER A O 1 ATOM 4510 C CB . SER A 1 599 ? 62.627 -27.836 -16.071 1.00 12.78 ? 599 SER A CB 1 ATOM 4511 O OG . SER A 1 599 ? 61.526 -28.728 -16.126 1.00 16.96 ? 599 SER A OG 1 ATOM 4512 N N . ARG A 1 600 ? 65.947 -28.009 -17.109 1.00 10.30 ? 600 ARG A N 1 ATOM 4513 C CA . ARG A 1 600 ? 67.077 -27.182 -17.449 1.00 9.62 ? 600 ARG A CA 1 ATOM 4514 C C . ARG A 1 600 ? 66.768 -26.225 -18.581 1.00 9.47 ? 600 ARG A C 1 ATOM 4515 O O . ARG A 1 600 ? 67.084 -26.472 -19.762 1.00 9.66 ? 600 ARG A O 1 ATOM 4516 C CB . ARG A 1 600 ? 68.275 -28.089 -17.752 1.00 9.73 ? 600 ARG A CB 1 ATOM 4517 C CG . ARG A 1 600 ? 68.684 -28.860 -16.471 1.00 9.98 ? 600 ARG A CG 1 ATOM 4518 C CD . ARG A 1 600 ? 69.388 -27.994 -15.445 1.00 7.37 ? 600 ARG A CD 1 ATOM 4519 N NE . ARG A 1 600 ? 69.698 -28.704 -14.213 1.00 10.48 ? 600 ARG A NE 1 ATOM 4520 C CZ . ARG A 1 600 ? 70.891 -29.261 -13.938 1.00 12.07 ? 600 ARG A CZ 1 ATOM 4521 N NH1 . ARG A 1 600 ? 71.928 -29.159 -14.787 1.00 8.86 ? 600 ARG A NH1 1 ATOM 4522 N NH2 . ARG A 1 600 ? 71.053 -29.885 -12.791 1.00 10.80 ? 600 ARG A NH2 1 ATOM 4523 N N . VAL A 1 601 ? 66.187 -25.102 -18.203 1.00 8.78 ? 601 VAL A N 1 ATOM 4524 C CA . VAL A 1 601 ? 65.757 -24.109 -19.157 1.00 7.92 ? 601 VAL A CA 1 ATOM 4525 C C . VAL A 1 601 ? 66.078 -22.710 -18.631 1.00 9.40 ? 601 VAL A C 1 ATOM 4526 O O . VAL A 1 601 ? 66.426 -22.516 -17.430 1.00 9.75 ? 601 VAL A O 1 ATOM 4527 C CB . VAL A 1 601 ? 64.236 -24.220 -19.373 1.00 8.62 ? 601 VAL A CB 1 ATOM 4528 C CG1 . VAL A 1 601 ? 63.869 -25.639 -19.868 1.00 6.51 ? 601 VAL A CG1 1 ATOM 4529 C CG2 . VAL A 1 601 ? 63.491 -23.937 -18.066 1.00 5.06 ? 601 VAL A CG2 1 ATOM 4530 N N . THR A 1 602 ? 65.973 -21.747 -19.535 1.00 9.06 ? 602 THR A N 1 ATOM 4531 C CA . THR A 1 602 ? 66.243 -20.366 -19.236 1.00 10.28 ? 602 THR A CA 1 ATOM 4532 C C . THR A 1 602 ? 65.050 -19.588 -19.754 1.00 10.55 ? 602 THR A C 1 ATOM 4533 O O . THR A 1 602 ? 64.657 -19.723 -20.906 1.00 11.08 ? 602 THR A O 1 ATOM 4534 C CB . THR A 1 602 ? 67.516 -19.933 -19.962 1.00 10.96 ? 602 THR A CB 1 ATOM 4535 O OG1 . THR A 1 602 ? 68.642 -20.607 -19.373 1.00 10.66 ? 602 THR A OG1 1 ATOM 4536 C CG2 . THR A 1 602 ? 67.781 -18.432 -19.761 1.00 10.35 ? 602 THR A CG2 1 ATOM 4537 N N . VAL A 1 603 ? 64.436 -18.785 -18.905 1.00 10.96 ? 603 VAL A N 1 ATOM 4538 C CA . VAL A 1 603 ? 63.246 -18.088 -19.349 1.00 10.96 ? 603 VAL A CA 1 ATOM 4539 C C . VAL A 1 603 ? 63.370 -16.624 -19.057 1.00 11.30 ? 603 VAL A C 1 ATOM 4540 O O . VAL A 1 603 ? 63.759 -16.238 -17.941 1.00 11.09 ? 603 VAL A O 1 ATOM 4541 C CB . VAL A 1 603 ? 62.025 -18.620 -18.607 1.00 10.81 ? 603 VAL A CB 1 ATOM 4542 C CG1 . VAL A 1 603 ? 60.774 -17.949 -19.112 1.00 11.37 ? 603 VAL A CG1 1 ATOM 4543 C CG2 . VAL A 1 603 ? 61.952 -20.101 -18.786 1.00 11.43 ? 603 VAL A CG2 1 ATOM 4544 N N . THR A 1 604 ? 62.995 -15.806 -20.034 1.00 10.98 ? 604 THR A N 1 ATOM 4545 C CA . THR A 1 604 ? 63.064 -14.352 -19.867 1.00 10.26 ? 604 THR A CA 1 ATOM 4546 C C . THR A 1 604 ? 61.777 -13.681 -20.312 1.00 9.67 ? 604 THR A C 1 ATOM 4547 O O . THR A 1 604 ? 61.069 -14.227 -21.158 1.00 9.08 ? 604 THR A O 1 ATOM 4548 C CB . THR A 1 604 ? 64.204 -13.787 -20.758 1.00 10.78 ? 604 THR A CB 1 ATOM 4549 O OG1 . THR A 1 604 ? 64.056 -14.299 -22.096 1.00 9.36 ? 604 THR A OG1 1 ATOM 4550 C CG2 . THR A 1 604 ? 65.603 -14.319 -20.263 1.00 8.22 ? 604 THR A CG2 1 ATOM 4551 N N . ASN A 1 605 ? 61.515 -12.487 -19.759 1.00 9.35 ? 605 ASN A N 1 ATOM 4552 C CA . ASN A 1 605 ? 60.423 -11.635 -20.229 1.00 7.75 ? 605 ASN A CA 1 ATOM 4553 C C . ASN A 1 605 ? 59.068 -12.321 -20.265 1.00 7.91 ? 605 ASN A C 1 ATOM 4554 O O . ASN A 1 605 ? 58.481 -12.463 -21.336 1.00 6.96 ? 605 ASN A O 1 ATOM 4555 C CB . ASN A 1 605 ? 60.715 -11.085 -21.625 1.00 7.67 ? 605 ASN A CB 1 ATOM 4556 C CG . ASN A 1 605 ? 61.896 -10.089 -21.671 1.00 7.81 ? 605 ASN A CG 1 ATOM 4557 O OD1 . ASN A 1 605 ? 62.687 -10.088 -22.646 1.00 10.42 ? 605 ASN A OD1 1 ATOM 4558 N ND2 . ASN A 1 605 ? 62.040 -9.273 -20.653 1.00 6.50 ? 605 ASN A ND2 1 ATOM 4559 N N . ILE A 1 606 ? 58.546 -12.681 -19.084 1.00 8.80 ? 606 ILE A N 1 ATOM 4560 C CA . ILE A 1 606 ? 57.267 -13.369 -18.970 1.00 9.49 ? 606 ILE A CA 1 ATOM 4561 C C . ILE A 1 606 ? 56.200 -12.326 -18.829 1.00 10.48 ? 606 ILE A C 1 ATOM 4562 O O . ILE A 1 606 ? 56.243 -11.490 -17.911 1.00 11.19 ? 606 ILE A O 1 ATOM 4563 C CB . ILE A 1 606 ? 57.263 -14.287 -17.760 1.00 9.53 ? 606 ILE A CB 1 ATOM 4564 C CG1 . ILE A 1 606 ? 58.385 -15.282 -17.906 1.00 11.37 ? 606 ILE A CG1 1 ATOM 4565 C CG2 . ILE A 1 606 ? 55.932 -15.047 -17.617 1.00 4.84 ? 606 ILE A CG2 1 ATOM 4566 C CD1 . ILE A 1 606 ? 58.271 -16.453 -16.929 1.00 19.25 ? 606 ILE A CD1 1 ATOM 4567 N N . VAL A 1 607 ? 55.257 -12.354 -19.751 1.00 9.66 ? 607 VAL A N 1 ATOM 4568 C CA . VAL A 1 607 ? 54.275 -11.308 -19.807 1.00 10.30 ? 607 VAL A CA 1 ATOM 4569 C C . VAL A 1 607 ? 52.869 -11.884 -19.567 1.00 10.54 ? 607 VAL A C 1 ATOM 4570 O O . VAL A 1 607 ? 52.535 -12.928 -20.108 1.00 9.88 ? 607 VAL A O 1 ATOM 4571 C CB . VAL A 1 607 ? 54.281 -10.642 -21.211 1.00 10.89 ? 607 VAL A CB 1 ATOM 4572 C CG1 . VAL A 1 607 ? 53.514 -9.288 -21.149 1.00 9.83 ? 607 VAL A CG1 1 ATOM 4573 C CG2 . VAL A 1 607 ? 55.704 -10.425 -21.722 1.00 10.55 ? 607 VAL A CG2 1 ATOM 4574 N N . LEU A 1 608 ? 52.052 -11.204 -18.758 1.00 11.16 ? 608 LEU A N 1 ATOM 4575 C CA . LEU A 1 608 ? 50.704 -11.724 -18.425 1.00 10.40 ? 608 LEU A CA 1 ATOM 4576 C C . LEU A 1 608 ? 49.618 -10.743 -18.837 1.00 10.49 ? 608 LEU A C 1 ATOM 4577 O O . LEU A 1 608 ? 49.664 -9.563 -18.443 1.00 10.02 ? 608 LEU A O 1 ATOM 4578 C CB . LEU A 1 608 ? 50.607 -12.021 -16.909 1.00 10.55 ? 608 LEU A CB 1 ATOM 4579 C CG . LEU A 1 608 ? 49.235 -12.428 -16.324 1.00 10.48 ? 608 LEU A CG 1 ATOM 4580 C CD1 . LEU A 1 608 ? 48.685 -13.677 -17.006 1.00 8.55 ? 608 LEU A CD1 1 ATOM 4581 C CD2 . LEU A 1 608 ? 49.279 -12.656 -14.779 1.00 7.26 ? 608 LEU A CD2 1 ATOM 4582 N N . TYR A 1 609 ? 48.667 -11.199 -19.658 1.00 10.12 ? 609 TYR A N 1 ATOM 4583 C CA . TYR A 1 609 ? 47.533 -10.343 -20.065 1.00 10.38 ? 609 TYR A CA 1 ATOM 4584 C C . TYR A 1 609 ? 46.197 -10.898 -19.566 1.00 10.23 ? 609 TYR A C 1 ATOM 4585 O O . TYR A 1 609 ? 46.029 -12.103 -19.506 1.00 9.16 ? 609 TYR A O 1 ATOM 4586 C CB . TYR A 1 609 ? 47.441 -10.220 -21.595 1.00 9.82 ? 609 TYR A CB 1 ATOM 4587 C CG . TYR A 1 609 ? 48.622 -9.514 -22.244 1.00 10.28 ? 609 TYR A CG 1 ATOM 4588 C CD1 . TYR A 1 609 ? 49.800 -10.214 -22.526 1.00 9.76 ? 609 TYR A CD1 1 ATOM 4589 C CD2 . TYR A 1 609 ? 48.545 -8.159 -22.609 1.00 9.76 ? 609 TYR A CD2 1 ATOM 4590 C CE1 . TYR A 1 609 ? 50.882 -9.607 -23.151 1.00 9.10 ? 609 TYR A CE1 1 ATOM 4591 C CE2 . TYR A 1 609 ? 49.645 -7.519 -23.236 1.00 9.10 ? 609 TYR A CE2 1 ATOM 4592 C CZ . TYR A 1 609 ? 50.792 -8.263 -23.492 1.00 10.51 ? 609 TYR A CZ 1 ATOM 4593 O OH . TYR A 1 609 ? 51.858 -7.683 -24.077 1.00 11.38 ? 609 TYR A OH 1 ATOM 4594 N N . ASN A 1 610 ? 45.228 -10.023 -19.286 1.00 10.65 ? 610 ASN A N 1 ATOM 4595 C CA . ASN A 1 610 ? 43.912 -10.477 -18.782 1.00 10.81 ? 610 ASN A CA 1 ATOM 4596 C C . ASN A 1 610 ? 42.888 -10.707 -19.879 1.00 11.40 ? 610 ASN A C 1 ATOM 4597 O O . ASN A 1 610 ? 41.657 -10.567 -19.672 1.00 11.48 ? 610 ASN A O 1 ATOM 4598 C CB . ASN A 1 610 ? 43.348 -9.574 -17.660 1.00 9.26 ? 610 ASN A CB 1 ATOM 4599 C CG . ASN A 1 610 ? 43.100 -8.144 -18.112 1.00 10.48 ? 610 ASN A CG 1 ATOM 4600 O OD1 . ASN A 1 610 ? 43.183 -7.825 -19.281 1.00 10.67 ? 610 ASN A OD1 1 ATOM 4601 N ND2 . ASN A 1 610 ? 42.746 -7.285 -17.171 1.00 9.16 ? 610 ASN A ND2 1 ATOM 4602 N N . ARG A 1 611 ? 43.401 -11.092 -21.039 1.00 11.60 ? 611 ARG A N 1 ATOM 4603 C CA . ARG A 1 611 ? 42.550 -11.346 -22.185 1.00 12.51 ? 611 ARG A CA 1 ATOM 4604 C C . ARG A 1 611 ? 43.317 -12.213 -23.140 1.00 12.45 ? 611 ARG A C 1 ATOM 4605 O O . ARG A 1 611 ? 44.535 -12.382 -22.988 1.00 11.46 ? 611 ARG A O 1 ATOM 4606 C CB . ARG A 1 611 ? 42.160 -10.026 -22.854 1.00 12.48 ? 611 ARG A CB 1 ATOM 4607 C CG . ARG A 1 611 ? 43.363 -9.191 -23.379 1.00 13.79 ? 611 ARG A CG 1 ATOM 4608 C CD . ARG A 1 611 ? 42.982 -7.805 -23.991 1.00 13.51 ? 611 ARG A CD 1 ATOM 4609 N NE . ARG A 1 611 ? 44.175 -7.044 -24.429 1.00 11.23 ? 611 ARG A NE 1 ATOM 4610 C CZ . ARG A 1 611 ? 44.697 -7.107 -25.660 1.00 13.22 ? 611 ARG A CZ 1 ATOM 4611 N NH1 . ARG A 1 611 ? 44.157 -7.905 -26.591 1.00 9.21 ? 611 ARG A NH1 1 ATOM 4612 N NH2 . ARG A 1 611 ? 45.770 -6.400 -25.956 1.00 9.92 ? 611 ARG A NH2 1 ATOM 4613 N N . ARG A 1 612 ? 42.614 -12.764 -24.126 1.00 12.30 ? 612 ARG A N 1 ATOM 4614 C CA . ARG A 1 612 ? 43.252 -13.615 -25.117 1.00 13.13 ? 612 ARG A CA 1 ATOM 4615 C C . ARG A 1 612 ? 43.761 -12.731 -26.233 1.00 12.66 ? 612 ARG A C 1 ATOM 4616 O O . ARG A 1 612 ? 42.970 -12.173 -26.998 1.00 13.55 ? 612 ARG A O 1 ATOM 4617 C CB . ARG A 1 612 ? 42.269 -14.677 -25.689 1.00 13.75 ? 612 ARG A CB 1 ATOM 4618 C CG . ARG A 1 612 ? 42.853 -15.385 -26.935 1.00 17.35 ? 612 ARG A CG 1 ATOM 4619 C CD . ARG A 1 612 ? 42.172 -16.659 -27.384 1.00 23.55 ? 612 ARG A CD 1 ATOM 4620 N NE . ARG A 1 612 ? 40.763 -16.492 -27.706 1.00 26.01 ? 612 ARG A NE 1 ATOM 4621 C CZ . ARG A 1 612 ? 39.882 -17.485 -27.788 1.00 26.97 ? 612 ARG A CZ 1 ATOM 4622 N NH1 . ARG A 1 612 ? 40.246 -18.757 -27.581 1.00 25.97 ? 612 ARG A NH1 1 ATOM 4623 N NH2 . ARG A 1 612 ? 38.622 -17.194 -28.082 1.00 24.10 ? 612 ARG A NH2 1 ATOM 4624 N N . LEU A 1 613 ? 45.071 -12.552 -26.324 1.00 13.00 ? 613 LEU A N 1 ATOM 4625 C CA . LEU A 1 613 ? 45.647 -11.763 -27.418 1.00 13.97 ? 613 LEU A CA 1 ATOM 4626 C C . LEU A 1 613 ? 45.249 -12.321 -28.792 1.00 14.60 ? 613 LEU A C 1 ATOM 4627 O O . LEU A 1 613 ? 45.167 -13.544 -28.964 1.00 13.71 ? 613 LEU A O 1 ATOM 4628 C CB . LEU A 1 613 ? 47.173 -11.747 -27.302 1.00 13.91 ? 613 LEU A CB 1 ATOM 4629 C CG . LEU A 1 613 ? 47.786 -10.877 -26.183 1.00 15.91 ? 613 LEU A CG 1 ATOM 4630 C CD1 . LEU A 1 613 ? 49.225 -10.481 -26.531 1.00 15.35 ? 613 LEU A CD1 1 ATOM 4631 C CD2 . LEU A 1 613 ? 46.932 -9.719 -25.747 1.00 12.43 ? 613 LEU A CD2 1 ATOM 4632 N N . ASN A 1 614 ? 44.971 -11.472 -29.783 1.00 14.92 ? 614 ASN A N 1 ATOM 4633 C CA . ASN A 1 614 ? 44.675 -12.096 -31.096 1.00 16.69 ? 614 ASN A CA 1 ATOM 4634 C C . ASN A 1 614 ? 45.941 -12.530 -31.873 1.00 16.74 ? 614 ASN A C 1 ATOM 4635 O O . ASN A 1 614 ? 47.063 -12.282 -31.410 1.00 14.79 ? 614 ASN A O 1 ATOM 4636 C CB . ASN A 1 614 ? 43.715 -11.268 -31.980 1.00 16.82 ? 614 ASN A CB 1 ATOM 4637 C CG . ASN A 1 614 ? 44.321 -9.957 -32.460 1.00 20.73 ? 614 ASN A CG 1 ATOM 4638 O OD1 . ASN A 1 614 ? 45.536 -9.870 -32.777 1.00 16.24 ? 614 ASN A OD1 1 ATOM 4639 N ND2 . ASN A 1 614 ? 43.465 -8.908 -32.496 1.00 24.42 ? 614 ASN A ND2 1 ATOM 4640 N N . SER A 1 615 ? 45.747 -13.178 -33.035 1.00 17.26 ? 615 SER A N 1 ATOM 4641 C CA . SER A 1 615 ? 46.878 -13.730 -33.787 1.00 18.63 ? 615 SER A CA 1 ATOM 4642 C C . SER A 1 615 ? 47.920 -12.675 -34.188 1.00 17.76 ? 615 SER A C 1 ATOM 4643 O O . SER A 1 615 ? 49.114 -12.943 -34.121 1.00 18.98 ? 615 SER A O 1 ATOM 4644 C CB . SER A 1 615 ? 46.436 -14.549 -35.023 1.00 19.32 ? 615 SER A CB 1 ATOM 4645 O OG . SER A 1 615 ? 45.611 -13.762 -35.865 1.00 22.15 ? 615 SER A OG 1 ATOM 4646 N N . SER A 1 616 ? 47.502 -11.483 -34.557 1.00 15.95 ? 616 SER A N 1 ATOM 4647 C CA . SER A 1 616 ? 48.513 -10.518 -34.949 1.00 16.69 ? 616 SER A CA 1 ATOM 4648 C C . SER A 1 616 ? 49.216 -9.843 -33.761 1.00 15.01 ? 616 SER A C 1 ATOM 4649 O O . SER A 1 616 ? 50.363 -9.377 -33.871 1.00 13.60 ? 616 SER A O 1 ATOM 4650 C CB . SER A 1 616 ? 48.000 -9.522 -35.994 1.00 16.57 ? 616 SER A CB 1 ATOM 4651 O OG . SER A 1 616 ? 46.922 -8.821 -35.469 1.00 21.97 ? 616 SER A OG 1 ATOM 4652 N N . GLU A 1 617 ? 48.514 -9.774 -32.639 1.00 14.04 ? 617 GLU A N 1 ATOM 4653 C CA . GLU A 1 617 ? 49.130 -9.309 -31.407 1.00 13.74 ? 617 GLU A CA 1 ATOM 4654 C C . GLU A 1 617 ? 50.203 -10.313 -31.003 1.00 13.42 ? 617 GLU A C 1 ATOM 4655 O O . GLU A 1 617 ? 51.290 -9.963 -30.608 1.00 13.90 ? 617 GLU A O 1 ATOM 4656 C CB . GLU A 1 617 ? 48.069 -9.182 -30.324 1.00 13.58 ? 617 GLU A CB 1 ATOM 4657 C CG . GLU A 1 617 ? 47.164 -7.980 -30.562 1.00 12.78 ? 617 GLU A CG 1 ATOM 4658 C CD . GLU A 1 617 ? 46.121 -7.867 -29.505 1.00 13.77 ? 617 GLU A CD 1 ATOM 4659 O OE1 . GLU A 1 617 ? 45.404 -8.882 -29.308 1.00 18.18 ? 617 GLU A OE1 1 ATOM 4660 O OE2 . GLU A 1 617 ? 46.036 -6.787 -28.865 1.00 13.99 ? 617 GLU A OE2 1 ATOM 4661 N N . ILE A 1 618 ? 49.879 -11.583 -31.107 1.00 13.45 ? 618 ILE A N 1 ATOM 4662 C CA . ILE A 1 618 ? 50.837 -12.607 -30.804 1.00 13.75 ? 618 ILE A CA 1 ATOM 4663 C C . ILE A 1 618 ? 52.075 -12.428 -31.714 1.00 14.23 ? 618 ILE A C 1 ATOM 4664 O O . ILE A 1 618 ? 53.197 -12.520 -31.241 1.00 13.61 ? 618 ILE A O 1 ATOM 4665 C CB . ILE A 1 618 ? 50.171 -13.997 -30.961 1.00 13.18 ? 618 ILE A CB 1 ATOM 4666 C CG1 . ILE A 1 618 ? 49.252 -14.271 -29.753 1.00 12.63 ? 618 ILE A CG1 1 ATOM 4667 C CG2 . ILE A 1 618 ? 51.208 -15.107 -31.084 1.00 13.14 ? 618 ILE A CG2 1 ATOM 4668 C CD1 . ILE A 1 618 ? 48.339 -15.487 -29.865 1.00 5.20 ? 618 ILE A CD1 1 ATOM 4669 N N . ARG A 1 619 ? 51.857 -12.138 -32.999 1.00 14.67 ? 619 ARG A N 1 ATOM 4670 C CA . ARG A 1 619 ? 52.956 -12.034 -33.966 1.00 15.85 ? 619 ARG A CA 1 ATOM 4671 C C . ARG A 1 619 ? 53.826 -10.834 -33.653 1.00 14.68 ? 619 ARG A C 1 ATOM 4672 O O . ARG A 1 619 ? 55.064 -10.874 -33.834 1.00 14.78 ? 619 ARG A O 1 ATOM 4673 C CB . ARG A 1 619 ? 52.425 -11.928 -35.434 1.00 16.88 ? 619 ARG A CB 1 ATOM 4674 C CG . ARG A 1 619 ? 53.525 -11.806 -36.499 1.00 20.80 ? 619 ARG A CG 1 ATOM 4675 C CD . ARG A 1 619 ? 53.023 -11.649 -37.953 1.00 27.25 ? 619 ARG A CD 1 ATOM 4676 N NE . ARG A 1 619 ? 51.880 -10.732 -37.997 1.00 32.77 ? 619 ARG A NE 1 ATOM 4677 C CZ . ARG A 1 619 ? 50.990 -10.666 -38.987 1.00 36.59 ? 619 ARG A CZ 1 ATOM 4678 N NH1 . ARG A 1 619 ? 51.100 -11.473 -40.043 1.00 37.27 ? 619 ARG A NH1 1 ATOM 4679 N NH2 . ARG A 1 619 ? 49.986 -9.795 -38.913 1.00 36.49 ? 619 ARG A NH2 1 ATOM 4680 N N . THR A 1 620 ? 53.172 -9.777 -33.176 1.00 13.50 ? 620 THR A N 1 ATOM 4681 C CA . THR A 1 620 ? 53.881 -8.584 -32.783 1.00 13.64 ? 620 THR A CA 1 ATOM 4682 C C . THR A 1 620 ? 54.820 -8.923 -31.636 1.00 13.70 ? 620 THR A C 1 ATOM 4683 O O . THR A 1 620 ? 55.981 -8.544 -31.635 1.00 13.67 ? 620 THR A O 1 ATOM 4684 C CB . THR A 1 620 ? 52.927 -7.491 -32.337 1.00 13.58 ? 620 THR A CB 1 ATOM 4685 O OG1 . THR A 1 620 ? 52.014 -7.184 -33.399 1.00 14.74 ? 620 THR A OG1 1 ATOM 4686 C CG2 . THR A 1 620 ? 53.703 -6.152 -32.169 1.00 14.48 ? 620 THR A CG2 1 ATOM 4687 N N . LEU A 1 621 ? 54.311 -9.636 -30.638 1.00 13.35 ? 621 LEU A N 1 ATOM 4688 C CA . LEU A 1 621 ? 55.178 -10.007 -29.540 1.00 12.45 ? 621 LEU A CA 1 ATOM 4689 C C . LEU A 1 621 ? 56.278 -10.932 -30.076 1.00 12.48 ? 621 LEU A C 1 ATOM 4690 O O . LEU A 1 621 ? 57.460 -10.795 -29.734 1.00 10.86 ? 621 LEU A O 1 ATOM 4691 C CB . LEU A 1 621 ? 54.399 -10.645 -28.389 1.00 12.01 ? 621 LEU A CB 1 ATOM 4692 C CG . LEU A 1 621 ? 53.445 -9.755 -27.590 1.00 12.73 ? 621 LEU A CG 1 ATOM 4693 C CD1 . LEU A 1 621 ? 52.619 -10.637 -26.657 1.00 12.55 ? 621 LEU A CD1 1 ATOM 4694 C CD2 . LEU A 1 621 ? 54.230 -8.739 -26.809 1.00 14.27 ? 621 LEU A CD2 1 ATOM 4695 N N . PHE A 1 622 ? 55.924 -11.875 -30.941 1.00 12.21 ? 622 PHE A N 1 ATOM 4696 C CA . PHE A 1 622 ? 57.014 -12.720 -31.440 1.00 12.84 ? 622 PHE A CA 1 ATOM 4697 C C . PHE A 1 622 ? 58.102 -11.852 -32.102 1.00 12.81 ? 622 PHE A C 1 ATOM 4698 O O . PHE A 1 622 ? 59.271 -11.996 -31.793 1.00 13.02 ? 622 PHE A O 1 ATOM 4699 C CB . PHE A 1 622 ? 56.470 -13.824 -32.348 1.00 11.12 ? 622 PHE A CB 1 ATOM 4700 C CG . PHE A 1 622 ? 57.475 -14.474 -33.246 1.00 13.11 ? 622 PHE A CG 1 ATOM 4701 C CD1 . PHE A 1 622 ? 58.528 -15.200 -32.743 1.00 13.41 ? 622 PHE A CD1 1 ATOM 4702 C CD2 . PHE A 1 622 ? 57.279 -14.462 -34.637 1.00 14.26 ? 622 PHE A CD2 1 ATOM 4703 C CE1 . PHE A 1 622 ? 59.416 -15.847 -33.608 1.00 13.55 ? 622 PHE A CE1 1 ATOM 4704 C CE2 . PHE A 1 622 ? 58.154 -15.119 -35.522 1.00 12.31 ? 622 PHE A CE2 1 ATOM 4705 C CZ . PHE A 1 622 ? 59.230 -15.801 -35.008 1.00 13.68 ? 622 PHE A CZ 1 ATOM 4706 N N . LEU A 1 623 ? 57.717 -10.904 -32.951 1.00 13.21 ? 623 LEU A N 1 ATOM 4707 C CA . LEU A 1 623 ? 58.717 -10.127 -33.675 1.00 12.11 ? 623 LEU A CA 1 ATOM 4708 C C . LEU A 1 623 ? 59.491 -9.142 -32.821 1.00 12.51 ? 623 LEU A C 1 ATOM 4709 O O . LEU A 1 623 ? 60.574 -8.698 -33.211 1.00 12.26 ? 623 LEU A O 1 ATOM 4710 C CB . LEU A 1 623 ? 58.039 -9.396 -34.832 1.00 12.43 ? 623 LEU A CB 1 ATOM 4711 C CG . LEU A 1 623 ? 57.425 -10.325 -35.892 1.00 14.28 ? 623 LEU A CG 1 ATOM 4712 C CD1 . LEU A 1 623 ? 56.644 -9.556 -36.913 1.00 12.48 ? 623 LEU A CD1 1 ATOM 4713 C CD2 . LEU A 1 623 ? 58.466 -11.210 -36.590 1.00 14.74 ? 623 LEU A CD2 1 ATOM 4714 N N . SER A 1 624 ? 58.940 -8.765 -31.668 1.00 11.95 ? 624 SER A N 1 ATOM 4715 C CA . SER A 1 624 ? 59.580 -7.756 -30.857 1.00 12.62 ? 624 SER A CA 1 ATOM 4716 C C . SER A 1 624 ? 60.194 -8.274 -29.576 1.00 13.25 ? 624 SER A C 1 ATOM 4717 O O . SER A 1 624 ? 60.508 -7.486 -28.662 1.00 12.62 ? 624 SER A O 1 ATOM 4718 C CB . SER A 1 624 ? 58.570 -6.676 -30.466 1.00 12.92 ? 624 SER A CB 1 ATOM 4719 O OG . SER A 1 624 ? 57.580 -7.203 -29.599 1.00 14.75 ? 624 SER A OG 1 ATOM 4720 N N . GLN A 1 625 ? 60.423 -9.573 -29.504 1.00 13.54 ? 625 GLN A N 1 ATOM 4721 C CA . GLN A 1 625 ? 60.885 -10.119 -28.245 1.00 14.79 ? 625 GLN A CA 1 ATOM 4722 C C . GLN A 1 625 ? 62.230 -9.654 -27.700 1.00 14.54 ? 625 GLN A C 1 ATOM 4723 O O . GLN A 1 625 ? 62.431 -9.602 -26.484 1.00 13.47 ? 625 GLN A O 1 ATOM 4724 C CB . GLN A 1 625 ? 60.725 -11.639 -28.218 1.00 15.23 ? 625 GLN A CB 1 ATOM 4725 C CG . GLN A 1 625 ? 61.851 -12.407 -28.796 1.00 16.78 ? 625 GLN A CG 1 ATOM 4726 C CD . GLN A 1 625 ? 61.486 -13.896 -28.989 1.00 19.38 ? 625 GLN A CD 1 ATOM 4727 O OE1 . GLN A 1 625 ? 61.516 -14.402 -30.120 1.00 21.91 ? 625 GLN A OE1 1 ATOM 4728 N NE2 . GLN A 1 625 ? 61.150 -14.584 -27.901 1.00 11.62 ? 625 GLN A NE2 1 ATOM 4729 N N . ASP A 1 626 ? 63.115 -9.216 -28.580 1.00 15.11 ? 626 ASP A N 1 ATOM 4730 C CA . ASP A 1 626 ? 64.392 -8.729 -28.121 1.00 15.46 ? 626 ASP A CA 1 ATOM 4731 C C . ASP A 1 626 ? 64.306 -7.245 -27.795 1.00 15.01 ? 626 ASP A C 1 ATOM 4732 O O . ASP A 1 626 ? 65.311 -6.614 -27.464 1.00 14.56 ? 626 ASP A O 1 ATOM 4733 C CB . ASP A 1 626 ? 65.451 -8.927 -29.210 1.00 17.10 ? 626 ASP A CB 1 ATOM 4734 C CG . ASP A 1 626 ? 65.792 -10.385 -29.442 1.00 22.27 ? 626 ASP A CG 1 ATOM 4735 O OD1 . ASP A 1 626 ? 65.487 -11.265 -28.572 1.00 26.27 ? 626 ASP A OD1 1 ATOM 4736 O OD2 . ASP A 1 626 ? 66.360 -10.738 -30.497 1.00 29.02 ? 626 ASP A OD2 1 ATOM 4737 N N . MET A 1 627 ? 63.104 -6.690 -27.890 1.00 14.49 ? 627 MET A N 1 ATOM 4738 C CA . MET A 1 627 ? 62.935 -5.252 -27.663 1.00 14.68 ? 627 MET A CA 1 ATOM 4739 C C . MET A 1 627 ? 62.276 -4.872 -26.329 1.00 13.94 ? 627 MET A C 1 ATOM 4740 O O . MET A 1 627 ? 62.435 -3.733 -25.867 1.00 13.61 ? 627 MET A O 1 ATOM 4741 C CB . MET A 1 627 ? 62.171 -4.576 -28.833 1.00 15.90 ? 627 MET A CB 1 ATOM 4742 C CG . MET A 1 627 ? 62.592 -5.017 -30.201 1.00 16.01 ? 627 MET A CG 1 ATOM 4743 S SD . MET A 1 627 ? 61.808 -4.186 -31.584 1.00 19.42 ? 627 MET A SD 1 ATOM 4744 C CE . MET A 1 627 ? 60.326 -4.451 -31.336 1.00 24.99 ? 627 MET A CE 1 ATOM 4745 N N . ILE A 1 628 ? 61.593 -5.816 -25.673 1.00 12.20 ? 628 ILE A N 1 ATOM 4746 C CA . ILE A 1 628 ? 60.784 -5.415 -24.521 1.00 11.72 ? 628 ILE A CA 1 ATOM 4747 C C . ILE A 1 628 ? 61.441 -5.497 -23.156 1.00 11.38 ? 628 ILE A C 1 ATOM 4748 O O . ILE A 1 628 ? 60.869 -5.021 -22.193 1.00 11.00 ? 628 ILE A O 1 ATOM 4749 C CB . ILE A 1 628 ? 59.472 -6.234 -24.471 1.00 12.17 ? 628 ILE A CB 1 ATOM 4750 C CG1 . ILE A 1 628 ? 59.788 -7.718 -24.343 1.00 9.37 ? 628 ILE A CG1 1 ATOM 4751 C CG2 . ILE A 1 628 ? 58.731 -6.107 -25.763 1.00 13.32 ? 628 ILE A CG2 1 ATOM 4752 C CD1 . ILE A 1 628 ? 58.541 -8.539 -23.958 1.00 11.31 ? 628 ILE A CD1 1 ATOM 4753 N N . GLY A 1 629 ? 62.624 -6.093 -23.042 1.00 11.31 ? 629 GLY A N 1 ATOM 4754 C CA . GLY A 1 629 ? 63.194 -6.303 -21.708 1.00 12.31 ? 629 GLY A CA 1 ATOM 4755 C C . GLY A 1 629 ? 63.584 -5.057 -20.919 1.00 13.23 ? 629 GLY A C 1 ATOM 4756 O O . GLY A 1 629 ? 63.849 -4.019 -21.500 1.00 12.76 ? 629 GLY A O 1 ATOM 4757 N N . THR A 1 630 ? 63.575 -5.145 -19.595 1.00 13.94 ? 630 THR A N 1 ATOM 4758 C CA . THR A 1 630 ? 63.957 -4.007 -18.773 1.00 15.18 ? 630 THR A CA 1 ATOM 4759 C C . THR A 1 630 ? 65.490 -3.848 -18.565 1.00 16.28 ? 630 THR A C 1 ATOM 4760 O O . THR A 1 630 ? 65.925 -2.912 -17.901 1.00 15.79 ? 630 THR A O 1 ATOM 4761 C CB . THR A 1 630 ? 63.178 -4.012 -17.448 1.00 15.31 ? 630 THR A CB 1 ATOM 4762 O OG1 . THR A 1 630 ? 63.545 -5.165 -16.669 1.00 15.71 ? 630 THR A OG1 1 ATOM 4763 C CG2 . THR A 1 630 ? 61.661 -4.152 -17.750 1.00 14.32 ? 630 THR A CG2 1 ATOM 4764 N N . ASP A 1 631 ? 66.247 -4.817 -19.095 1.00 17.42 ? 631 ASP A N 1 ATOM 4765 C CA . ASP A 1 631 ? 67.724 -4.801 -19.342 1.00 19.39 ? 631 ASP A CA 1 ATOM 4766 C C . ASP A 1 631 ? 68.649 -5.758 -18.581 1.00 20.64 ? 631 ASP A C 1 ATOM 4767 O O . ASP A 1 631 ? 69.920 -5.764 -18.757 1.00 23.26 ? 631 ASP A O 1 ATOM 4768 C CB . ASP A 1 631 ? 68.349 -3.295 -19.525 1.00 18.80 ? 631 ASP A CB 1 HETATM 4769 C C1 . NAG B 2 . ? 36.691 14.159 25.173 1.00 44.46 ? 651 NAG A C1 1 HETATM 4770 C C2 . NAG B 2 . ? 36.950 14.176 26.682 1.00 48.19 ? 651 NAG A C2 1 HETATM 4771 C C3 . NAG B 2 . ? 37.947 15.255 27.082 1.00 49.37 ? 651 NAG A C3 1 HETATM 4772 C C4 . NAG B 2 . ? 39.196 15.180 26.223 1.00 49.11 ? 651 NAG A C4 1 HETATM 4773 C C5 . NAG B 2 . ? 38.851 15.041 24.749 1.00 48.77 ? 651 NAG A C5 1 HETATM 4774 C C6 . NAG B 2 . ? 40.136 14.793 23.969 1.00 49.37 ? 651 NAG A C6 1 HETATM 4775 C C7 . NAG B 2 . ? 35.271 13.431 28.259 1.00 53.58 ? 651 NAG A C7 1 HETATM 4776 C C8 . NAG B 2 . ? 33.776 13.391 28.469 1.00 53.95 ? 651 NAG A C8 1 HETATM 4777 N N2 . NAG B 2 . ? 35.730 14.378 27.430 1.00 50.86 ? 651 NAG A N2 1 HETATM 4778 O O3 . NAG B 2 . ? 38.305 15.109 28.442 1.00 49.78 ? 651 NAG A O3 1 HETATM 4779 O O4 . NAG B 2 . ? 39.900 16.390 26.377 1.00 51.35 ? 651 NAG A O4 1 HETATM 4780 O O5 . NAG B 2 . ? 37.943 13.976 24.537 1.00 45.69 ? 651 NAG A O5 1 HETATM 4781 O O6 . NAG B 2 . ? 40.930 13.867 24.681 1.00 49.17 ? 651 NAG A O6 1 HETATM 4782 O O7 . NAG B 2 . ? 36.007 12.614 28.834 1.00 54.40 ? 651 NAG A O7 1 HETATM 4783 C C1 . NAG C 2 . ? 11.567 22.525 25.048 1.00 58.95 ? 652 NAG A C1 1 HETATM 4784 C C2 . NAG C 2 . ? 11.742 23.486 26.232 1.00 63.29 ? 652 NAG A C2 1 HETATM 4785 C C3 . NAG C 2 . ? 13.078 23.192 26.902 1.00 63.92 ? 652 NAG A C3 1 HETATM 4786 C C4 . NAG C 2 . ? 12.944 21.804 27.476 1.00 63.82 ? 652 NAG A C4 1 HETATM 4787 C C5 . NAG C 2 . ? 12.703 20.845 26.312 1.00 63.15 ? 652 NAG A C5 1 HETATM 4788 C C6 . NAG C 2 . ? 12.539 19.422 26.836 1.00 64.90 ? 652 NAG A C6 1 HETATM 4789 C C7 . NAG C 2 . ? 10.573 25.642 25.890 1.00 67.97 ? 652 NAG A C7 1 HETATM 4790 C C8 . NAG C 2 . ? 10.654 27.034 25.306 1.00 67.74 ? 652 NAG A C8 1 HETATM 4791 N N2 . NAG C 2 . ? 11.686 24.892 25.861 1.00 65.92 ? 652 NAG A N2 1 HETATM 4792 O O3 . NAG C 2 . ? 13.428 24.111 27.917 1.00 63.77 ? 652 NAG A O3 1 HETATM 4793 O O4 . NAG C 2 . ? 14.139 21.497 28.155 1.00 65.63 ? 652 NAG A O4 1 HETATM 4794 O O5 . NAG C 2 . ? 11.555 21.206 25.557 1.00 60.50 ? 652 NAG A O5 1 HETATM 4795 O O6 . NAG C 2 . ? 12.955 19.395 28.189 1.00 67.64 ? 652 NAG A O6 1 HETATM 4796 O O7 . NAG C 2 . ? 9.509 25.228 26.362 1.00 68.25 ? 652 NAG A O7 1 HETATM 4797 C C1 . NAG D 2 . ? 6.830 7.252 10.583 1.00 39.60 ? 653 NAG A C1 1 HETATM 4798 C C2 . NAG D 2 . ? 5.860 7.161 9.419 1.00 44.55 ? 653 NAG A C2 1 HETATM 4799 C C3 . NAG D 2 . ? 5.588 8.545 8.845 1.00 46.46 ? 653 NAG A C3 1 HETATM 4800 C C4 . NAG D 2 . ? 5.125 9.494 9.938 1.00 46.65 ? 653 NAG A C4 1 HETATM 4801 C C5 . NAG D 2 . ? 6.151 9.442 11.079 1.00 44.85 ? 653 NAG A C5 1 HETATM 4802 C C6 . NAG D 2 . ? 5.818 10.411 12.214 1.00 45.37 ? 653 NAG A C6 1 HETATM 4803 C C7 . NAG D 2 . ? 5.854 5.338 7.822 1.00 47.86 ? 653 NAG A C7 1 HETATM 4804 C C8 . NAG D 2 . ? 6.723 4.358 7.099 1.00 48.33 ? 653 NAG A C8 1 HETATM 4805 N N2 . NAG D 2 . ? 6.468 6.384 8.367 1.00 46.71 ? 653 NAG A N2 1 HETATM 4806 O O3 . NAG D 2 . ? 4.669 8.476 7.772 1.00 47.17 ? 653 NAG A O3 1 HETATM 4807 O O4 . NAG D 2 . ? 5.063 10.802 9.390 1.00 47.99 ? 653 NAG A O4 1 HETATM 4808 O O5 . NAG D 2 . ? 6.282 8.113 11.560 1.00 42.04 ? 653 NAG A O5 1 HETATM 4809 O O6 . NAG D 2 . ? 4.608 10.034 12.826 1.00 48.22 ? 653 NAG A O6 1 HETATM 4810 O O7 . NAG D 2 . ? 4.638 5.156 7.897 1.00 49.90 ? 653 NAG A O7 1 HETATM 4811 C C1 . NAG E 2 . ? 65.260 -10.637 -3.227 1.00 44.63 ? 654 NAG A C1 1 HETATM 4812 C C2 . NAG E 2 . ? 65.395 -10.254 -1.757 1.00 51.62 ? 654 NAG A C2 1 HETATM 4813 C C3 . NAG E 2 . ? 64.062 -9.798 -1.135 1.00 52.56 ? 654 NAG A C3 1 HETATM 4814 C C4 . NAG E 2 . ? 63.184 -8.946 -2.055 1.00 53.46 ? 654 NAG A C4 1 HETATM 4815 C C5 . NAG E 2 . ? 63.440 -9.282 -3.527 1.00 51.71 ? 654 NAG A C5 1 HETATM 4816 C C6 . NAG E 2 . ? 63.059 -8.208 -4.513 1.00 52.54 ? 654 NAG A C6 1 HETATM 4817 C C7 . NAG E 2 . ? 65.739 -12.633 -1.184 1.00 56.32 ? 654 NAG A C7 1 HETATM 4818 C C8 . NAG E 2 . ? 64.524 -13.170 -0.464 1.00 56.78 ? 654 NAG A C8 1 HETATM 4819 N N2 . NAG E 2 . ? 66.014 -11.333 -0.998 1.00 54.68 ? 654 NAG A N2 1 HETATM 4820 O O3 . NAG E 2 . ? 64.303 -9.054 0.038 1.00 53.85 ? 654 NAG A O3 1 HETATM 4821 O O4 . NAG E 2 . ? 61.815 -9.151 -1.710 1.00 54.82 ? 654 NAG A O4 1 HETATM 4822 O O5 . NAG E 2 . ? 64.810 -9.453 -3.790 1.00 47.95 ? 654 NAG A O5 1 HETATM 4823 O O6 . NAG E 2 . ? 63.832 -8.547 -5.655 1.00 56.17 ? 654 NAG A O6 1 HETATM 4824 O O7 . NAG E 2 . ? 66.430 -13.380 -1.889 1.00 55.48 ? 654 NAG A O7 1 HETATM 4825 C C1 . NAG F 2 . ? 43.879 -7.732 -33.211 1.00 29.62 ? 655 NAG A C1 1 HETATM 4826 C C2 . NAG F 2 . ? 43.014 -7.278 -34.391 1.00 33.59 ? 655 NAG A C2 1 HETATM 4827 C C3 . NAG F 2 . ? 43.440 -5.938 -34.981 1.00 32.87 ? 655 NAG A C3 1 HETATM 4828 C C4 . NAG F 2 . ? 43.762 -4.977 -33.859 1.00 32.20 ? 655 NAG A C4 1 HETATM 4829 C C5 . NAG F 2 . ? 44.773 -5.623 -32.915 1.00 29.48 ? 655 NAG A C5 1 HETATM 4830 C C6 . NAG F 2 . ? 45.128 -4.721 -31.769 1.00 31.63 ? 655 NAG A C6 1 HETATM 4831 C C7 . NAG F 2 . ? 42.305 -9.237 -35.667 1.00 41.40 ? 655 NAG A C7 1 HETATM 4832 C C8 . NAG F 2 . ? 42.974 -10.535 -36.048 1.00 43.65 ? 655 NAG A C8 1 HETATM 4833 N N2 . NAG F 2 . ? 43.162 -8.247 -35.448 1.00 38.84 ? 655 NAG A N2 1 HETATM 4834 O O3 . NAG F 2 . ? 42.432 -5.377 -35.815 1.00 34.76 ? 655 NAG A O3 1 HETATM 4835 O O4 . NAG F 2 . ? 44.229 -3.780 -34.434 1.00 30.30 ? 655 NAG A O4 1 HETATM 4836 O O5 . NAG F 2 . ? 44.088 -6.672 -32.308 1.00 28.43 ? 655 NAG A O5 1 HETATM 4837 O O6 . NAG F 2 . ? 44.002 -4.769 -30.921 1.00 33.66 ? 655 NAG A O6 1 HETATM 4838 O O7 . NAG F 2 . ? 41.070 -9.115 -35.565 1.00 42.23 ? 655 NAG A O7 1 HETATM 4839 O O . HOH G 3 . ? 27.135 2.989 -2.461 1.00 9.65 ? 656 HOH A O 1 HETATM 4840 O O . HOH G 3 . ? 43.710 5.023 10.509 1.00 10.10 ? 657 HOH A O 1 HETATM 4841 O O . HOH G 3 . ? 45.763 -8.005 -11.309 1.00 6.78 ? 658 HOH A O 1 HETATM 4842 O O . HOH G 3 . ? 28.561 3.899 -4.535 1.00 6.14 ? 659 HOH A O 1 HETATM 4843 O O . HOH G 3 . ? 58.240 -37.723 -28.314 1.00 13.71 ? 660 HOH A O 1 HETATM 4844 O O . HOH G 3 . ? 25.455 -13.532 0.498 1.00 5.95 ? 661 HOH A O 1 HETATM 4845 O O . HOH G 3 . ? 50.634 -7.657 -11.740 1.00 8.49 ? 662 HOH A O 1 HETATM 4846 O O . HOH G 3 . ? 66.093 -26.388 -12.784 1.00 12.09 ? 663 HOH A O 1 HETATM 4847 O O . HOH G 3 . ? 31.790 5.398 2.704 1.00 10.29 ? 664 HOH A O 1 HETATM 4848 O O . HOH G 3 . ? 38.706 1.581 18.887 1.00 9.44 ? 665 HOH A O 1 HETATM 4849 O O . HOH G 3 . ? 44.636 -14.624 -7.944 1.00 9.34 ? 666 HOH A O 1 HETATM 4850 O O . HOH G 3 . ? 26.325 -3.808 -20.085 1.00 17.92 ? 667 HOH A O 1 HETATM 4851 O O . HOH G 3 . ? 62.892 -27.795 -12.218 1.00 7.50 ? 668 HOH A O 1 HETATM 4852 O O . HOH G 3 . ? 48.060 -6.841 -10.412 1.00 9.36 ? 669 HOH A O 1 HETATM 4853 O O . HOH G 3 . ? 57.903 -9.048 -27.324 1.00 9.27 ? 670 HOH A O 1 HETATM 4854 O O . HOH G 3 . ? 43.621 -2.965 12.275 1.00 11.63 ? 671 HOH A O 1 HETATM 4855 O O . HOH G 3 . ? 54.857 -17.658 -30.028 1.00 10.43 ? 672 HOH A O 1 HETATM 4856 O O . HOH G 3 . ? 58.791 -12.735 -24.104 1.00 6.36 ? 673 HOH A O 1 HETATM 4857 O O . HOH G 3 . ? 30.390 3.895 5.332 1.00 8.44 ? 674 HOH A O 1 HETATM 4858 O O . HOH G 3 . ? 25.337 7.193 7.661 1.00 15.28 ? 675 HOH A O 1 HETATM 4859 O O . HOH G 3 . ? 46.789 -10.572 -3.092 1.00 9.68 ? 676 HOH A O 1 HETATM 4860 O O . HOH G 3 . ? 32.347 6.038 -6.553 1.00 11.79 ? 677 HOH A O 1 HETATM 4861 O O . HOH G 3 . ? 66.276 -32.081 -17.091 1.00 15.81 ? 678 HOH A O 1 HETATM 4862 O O . HOH G 3 . ? 59.530 -25.711 -32.736 1.00 10.67 ? 679 HOH A O 1 HETATM 4863 O O . HOH G 3 . ? 47.452 -4.507 -28.959 1.00 14.66 ? 680 HOH A O 1 HETATM 4864 O O . HOH G 3 . ? 32.973 7.617 -10.885 1.00 7.48 ? 681 HOH A O 1 HETATM 4865 O O . HOH G 3 . ? 61.552 -8.240 -13.385 1.00 8.16 ? 682 HOH A O 1 HETATM 4866 O O . HOH G 3 . ? 28.813 0.395 -0.264 1.00 13.22 ? 683 HOH A O 1 HETATM 4867 O O . HOH G 3 . ? 30.531 -2.069 -0.623 1.00 12.25 ? 684 HOH A O 1 HETATM 4868 O O . HOH G 3 . ? 62.860 -2.506 -23.529 1.00 9.45 ? 685 HOH A O 1 HETATM 4869 O O . HOH G 3 . ? 38.003 -19.723 -9.217 1.00 15.13 ? 686 HOH A O 1 HETATM 4870 O O . HOH G 3 . ? 39.210 -8.826 2.710 1.00 17.03 ? 687 HOH A O 1 HETATM 4871 O O . HOH G 3 . ? 21.543 13.628 -17.330 1.00 16.00 ? 688 HOH A O 1 HETATM 4872 O O . HOH G 3 . ? 65.989 -24.315 -26.928 1.00 7.73 ? 689 HOH A O 1 HETATM 4873 O O . HOH G 3 . ? 27.411 -4.702 11.847 1.00 17.95 ? 690 HOH A O 1 HETATM 4874 O O . HOH G 3 . ? 29.470 -15.862 -10.052 1.00 20.27 ? 691 HOH A O 1 HETATM 4875 O O . HOH G 3 . ? 39.632 -18.399 -6.999 1.00 18.94 ? 692 HOH A O 1 HETATM 4876 O O . HOH G 3 . ? 23.179 -1.505 4.910 1.00 9.20 ? 693 HOH A O 1 HETATM 4877 O O . HOH G 3 . ? 37.807 11.511 -4.182 1.00 11.17 ? 694 HOH A O 1 HETATM 4878 O O . HOH G 3 . ? 35.831 -8.698 -5.770 1.00 8.39 ? 695 HOH A O 1 HETATM 4879 O O . HOH G 3 . ? 30.637 2.965 -0.471 1.00 9.48 ? 696 HOH A O 1 HETATM 4880 O O . HOH G 3 . ? 36.278 -4.379 -14.050 1.00 8.47 ? 697 HOH A O 1 HETATM 4881 O O . HOH G 3 . ? 49.903 1.661 11.786 1.00 10.05 ? 698 HOH A O 1 HETATM 4882 O O . HOH G 3 . ? 33.029 -10.888 0.644 1.00 8.88 ? 699 HOH A O 1 HETATM 4883 O O . HOH G 3 . ? 57.617 -27.179 -33.821 1.00 18.63 ? 700 HOH A O 1 HETATM 4884 O O . HOH G 3 . ? 42.520 -16.719 -8.091 1.00 11.59 ? 701 HOH A O 1 HETATM 4885 O O . HOH G 3 . ? 44.042 14.060 10.629 1.00 13.13 ? 702 HOH A O 1 HETATM 4886 O O . HOH G 3 . ? 22.371 -4.751 4.351 1.00 22.39 ? 703 HOH A O 1 HETATM 4887 O O . HOH G 3 . ? 42.279 -19.272 -8.811 1.00 10.89 ? 704 HOH A O 1 HETATM 4888 O O . HOH G 3 . ? 49.313 2.223 4.540 1.00 12.82 ? 705 HOH A O 1 HETATM 4889 O O . HOH G 3 . ? 63.425 -25.303 -34.253 1.00 21.61 ? 706 HOH A O 1 HETATM 4890 O O . HOH G 3 . ? 39.846 -1.026 -18.658 1.00 15.38 ? 707 HOH A O 1 HETATM 4891 O O . HOH G 3 . ? 35.559 -0.688 4.893 1.00 8.59 ? 708 HOH A O 1 HETATM 4892 O O . HOH G 3 . ? 37.042 -19.499 -20.281 1.00 8.55 ? 709 HOH A O 1 HETATM 4893 O O . HOH G 3 . ? 46.824 16.529 4.632 1.00 12.34 ? 710 HOH A O 1 HETATM 4894 O O . HOH G 3 . ? 62.564 -5.782 -14.427 1.00 12.98 ? 711 HOH A O 1 HETATM 4895 O O . HOH G 3 . ? 39.876 -8.403 -19.033 1.00 23.56 ? 712 HOH A O 1 HETATM 4896 O O . HOH G 3 . ? 68.405 -18.763 -30.970 1.00 19.70 ? 713 HOH A O 1 HETATM 4897 O O . HOH G 3 . ? 46.523 -31.847 -16.336 1.00 14.92 ? 714 HOH A O 1 HETATM 4898 O O . HOH G 3 . ? 62.452 -11.873 -25.052 1.00 9.01 ? 715 HOH A O 1 HETATM 4899 O O . HOH G 3 . ? 32.049 4.290 -2.514 1.00 11.74 ? 716 HOH A O 1 HETATM 4900 O O . HOH G 3 . ? 53.835 2.960 2.795 1.00 22.51 ? 717 HOH A O 1 HETATM 4901 O O . HOH G 3 . ? 15.562 18.020 0.534 1.00 13.42 ? 718 HOH A O 1 HETATM 4902 O O . HOH G 3 . ? 54.321 -28.285 -18.424 1.00 17.95 ? 719 HOH A O 1 HETATM 4903 O O . HOH G 3 . ? 63.952 -8.163 -24.733 1.00 12.99 ? 720 HOH A O 1 HETATM 4904 O O . HOH G 3 . ? 55.712 -0.090 -33.493 1.00 18.35 ? 721 HOH A O 1 HETATM 4905 O O . HOH G 3 . ? 46.465 -7.720 -2.016 1.00 9.51 ? 722 HOH A O 1 HETATM 4906 O O . HOH G 3 . ? 53.159 -6.866 -35.976 1.00 16.10 ? 723 HOH A O 1 HETATM 4907 O O . HOH G 3 . ? 51.804 14.871 -3.121 1.00 20.18 ? 724 HOH A O 1 HETATM 4908 O O . HOH G 3 . ? 46.036 14.109 11.876 1.00 13.14 ? 725 HOH A O 1 HETATM 4909 O O . HOH G 3 . ? 50.290 14.311 0.708 1.00 14.57 ? 726 HOH A O 1 HETATM 4910 O O . HOH G 3 . ? 37.971 6.702 22.593 1.00 24.57 ? 727 HOH A O 1 HETATM 4911 O O . HOH G 3 . ? 29.537 12.128 -5.696 1.00 17.71 ? 728 HOH A O 1 HETATM 4912 O O . HOH G 3 . ? 33.320 -15.083 -9.812 1.00 25.21 ? 729 HOH A O 1 HETATM 4913 O O . HOH G 3 . ? 31.878 8.544 -5.374 1.00 12.05 ? 730 HOH A O 1 HETATM 4914 O O . HOH G 3 . ? 23.585 -10.413 3.140 1.00 20.34 ? 731 HOH A O 1 HETATM 4915 O O . HOH G 3 . ? 34.965 -8.232 6.228 1.00 11.70 ? 732 HOH A O 1 HETATM 4916 O O . HOH G 3 . ? 41.226 17.667 11.892 1.00 30.99 ? 733 HOH A O 1 HETATM 4917 O O . HOH G 3 . ? 44.842 -9.548 1.165 1.00 14.76 ? 734 HOH A O 1 HETATM 4918 O O . HOH G 3 . ? 60.649 -2.821 -20.774 1.00 12.08 ? 735 HOH A O 1 HETATM 4919 O O . HOH G 3 . ? 34.380 7.413 0.037 1.00 16.02 ? 736 HOH A O 1 HETATM 4920 O O . HOH G 3 . ? 36.636 -16.359 -21.636 1.00 10.39 ? 737 HOH A O 1 HETATM 4921 O O . HOH G 3 . ? 52.115 -4.763 -37.730 1.00 12.34 ? 738 HOH A O 1 HETATM 4922 O O . HOH G 3 . ? 27.572 7.375 4.994 1.00 8.76 ? 739 HOH A O 1 HETATM 4923 O O . HOH G 3 . ? 59.959 -21.723 -7.272 1.00 17.98 ? 740 HOH A O 1 HETATM 4924 O O . HOH G 3 . ? 50.232 15.948 -1.631 1.00 16.21 ? 741 HOH A O 1 HETATM 4925 O O . HOH G 3 . ? 54.331 -9.780 -4.603 1.00 15.19 ? 742 HOH A O 1 HETATM 4926 O O . HOH G 3 . ? 37.584 -14.889 -13.148 1.00 13.18 ? 743 HOH A O 1 HETATM 4927 O O . HOH G 3 . ? 35.614 -20.583 9.601 1.00 26.00 ? 744 HOH A O 1 HETATM 4928 O O . HOH G 3 . ? 31.118 17.425 18.131 1.00 20.05 ? 745 HOH A O 1 HETATM 4929 O O . HOH G 3 . ? 57.353 -1.991 -5.538 1.00 21.31 ? 746 HOH A O 1 HETATM 4930 O O . HOH G 3 . ? 54.215 -26.526 -10.758 1.00 23.16 ? 747 HOH A O 1 HETATM 4931 O O . HOH G 3 . ? 66.992 -21.994 -4.253 1.00 18.83 ? 748 HOH A O 1 HETATM 4932 O O . HOH G 3 . ? 52.530 12.507 -2.581 1.00 21.41 ? 749 HOH A O 1 HETATM 4933 O O . HOH G 3 . ? 48.187 9.628 14.171 1.00 22.49 ? 750 HOH A O 1 HETATM 4934 O O . HOH G 3 . ? 36.767 6.764 -14.239 1.00 10.88 ? 751 HOH A O 1 HETATM 4935 O O . HOH G 3 . ? 62.447 -0.806 -19.887 1.00 19.10 ? 752 HOH A O 1 HETATM 4936 O O . HOH G 3 . ? 74.720 -30.565 -16.300 1.00 21.19 ? 753 HOH A O 1 HETATM 4937 O O . HOH G 3 . ? 44.050 7.571 -17.345 1.00 17.45 ? 754 HOH A O 1 HETATM 4938 O O . HOH G 3 . ? 67.687 -27.242 -3.756 1.00 20.18 ? 755 HOH A O 1 HETATM 4939 O O . HOH G 3 . ? 55.720 -5.972 -35.498 1.00 13.04 ? 756 HOH A O 1 HETATM 4940 O O . HOH G 3 . ? 26.497 2.721 -18.106 1.00 12.73 ? 757 HOH A O 1 HETATM 4941 O O . HOH G 3 . ? 39.922 -26.143 -11.133 1.00 13.51 ? 758 HOH A O 1 HETATM 4942 O O . HOH G 3 . ? 63.255 -20.152 -32.813 1.00 16.37 ? 759 HOH A O 1 HETATM 4943 O O . HOH G 3 . ? 71.627 -32.264 -22.900 1.00 16.87 ? 760 HOH A O 1 HETATM 4944 O O . HOH G 3 . ? 39.964 -2.249 18.407 1.00 17.02 ? 761 HOH A O 1 HETATM 4945 O O . HOH G 3 . ? 51.962 12.362 0.135 1.00 16.84 ? 762 HOH A O 1 HETATM 4946 O O . HOH G 3 . ? 35.945 -14.781 -10.912 1.00 13.83 ? 763 HOH A O 1 HETATM 4947 O O . HOH G 3 . ? 53.683 -5.001 -4.225 1.00 16.20 ? 764 HOH A O 1 HETATM 4948 O O . HOH G 3 . ? 60.590 -24.894 -6.512 1.00 26.40 ? 765 HOH A O 1 HETATM 4949 O O . HOH G 3 . ? 58.251 5.509 -9.795 1.00 11.47 ? 766 HOH A O 1 HETATM 4950 O O . HOH G 3 . ? 30.383 -14.712 -4.591 1.00 14.06 ? 767 HOH A O 1 HETATM 4951 O O . HOH G 3 . ? 20.338 -15.636 -9.053 1.00 16.96 ? 768 HOH A O 1 HETATM 4952 O O . HOH G 3 . ? 34.880 -9.889 -17.891 1.00 13.09 ? 769 HOH A O 1 HETATM 4953 O O . HOH G 3 . ? 46.138 -30.321 -9.119 1.00 22.85 ? 770 HOH A O 1 HETATM 4954 O O . HOH G 3 . ? 68.553 -32.763 -10.356 1.00 14.04 ? 771 HOH A O 1 HETATM 4955 O O . HOH G 3 . ? 65.776 -30.321 -19.082 1.00 14.85 ? 772 HOH A O 1 HETATM 4956 O O . HOH G 3 . ? 42.257 12.507 18.183 1.00 19.72 ? 773 HOH A O 1 HETATM 4957 O O . HOH G 3 . ? 52.533 -28.886 -33.831 1.00 13.47 ? 774 HOH A O 1 HETATM 4958 O O . HOH G 3 . ? 47.799 12.837 1.342 1.00 12.05 ? 775 HOH A O 1 HETATM 4959 O O . HOH G 3 . ? 44.417 -8.420 12.936 1.00 18.53 ? 776 HOH A O 1 HETATM 4960 O O . HOH G 3 . ? 39.881 -9.443 0.203 1.00 4.77 ? 777 HOH A O 1 HETATM 4961 O O . HOH G 3 . ? 55.978 -27.825 -12.329 1.00 15.92 ? 778 HOH A O 1 HETATM 4962 O O . HOH G 3 . ? 22.709 -11.406 -12.868 1.00 32.03 ? 779 HOH A O 1 HETATM 4963 O O . HOH G 3 . ? 14.473 9.611 -20.417 1.00 23.68 ? 780 HOH A O 1 HETATM 4964 O O . HOH G 3 . ? 21.413 4.702 19.349 1.00 18.75 ? 781 HOH A O 1 HETATM 4965 O O . HOH G 3 . ? 38.356 -14.459 9.853 1.00 16.53 ? 782 HOH A O 1 HETATM 4966 O O . HOH G 3 . ? 49.385 -11.117 -2.870 1.00 21.77 ? 783 HOH A O 1 HETATM 4967 O O . HOH G 3 . ? 41.855 -0.682 19.568 1.00 13.54 ? 784 HOH A O 1 HETATM 4968 O O . HOH G 3 . ? 51.086 16.109 2.634 1.00 22.91 ? 785 HOH A O 1 HETATM 4969 O O . HOH G 3 . ? 20.198 7.623 -18.888 1.00 16.59 ? 786 HOH A O 1 HETATM 4970 O O . HOH G 3 . ? 32.343 5.763 -0.007 1.00 13.67 ? 787 HOH A O 1 HETATM 4971 O O . HOH G 3 . ? 54.645 1.629 -31.714 1.00 13.57 ? 788 HOH A O 1 HETATM 4972 O O . HOH G 3 . ? 48.198 13.727 -8.941 1.00 20.73 ? 789 HOH A O 1 HETATM 4973 O O . HOH G 3 . ? 11.685 2.717 -12.554 1.00 13.34 ? 790 HOH A O 1 HETATM 4974 O O . HOH G 3 . ? 42.666 -7.705 -14.149 1.00 14.18 ? 791 HOH A O 1 HETATM 4975 O O . HOH G 3 . ? 37.758 15.853 -4.548 1.00 20.78 ? 792 HOH A O 1 HETATM 4976 O O . HOH G 3 . ? 31.967 -2.236 11.812 1.00 18.38 ? 793 HOH A O 1 HETATM 4977 O O . HOH G 3 . ? 19.734 -2.018 -12.188 1.00 13.44 ? 794 HOH A O 1 HETATM 4978 O O . HOH G 3 . ? 18.802 15.584 25.039 1.00 27.79 ? 795 HOH A O 1 HETATM 4979 O O . HOH G 3 . ? 34.717 9.929 -0.841 1.00 17.09 ? 796 HOH A O 1 HETATM 4980 O O . HOH G 3 . ? 64.967 -25.728 -2.554 1.00 27.61 ? 797 HOH A O 1 HETATM 4981 O O . HOH G 3 . ? 15.000 10.689 -14.417 1.00 22.43 ? 798 HOH A O 1 HETATM 4982 O O . HOH G 3 . ? 48.766 -7.741 -0.520 1.00 12.34 ? 799 HOH A O 1 HETATM 4983 O O . HOH G 3 . ? 53.371 -4.187 -39.943 1.00 19.49 ? 800 HOH A O 1 HETATM 4984 O O . HOH G 3 . ? 57.230 -11.345 -26.101 1.00 11.21 ? 801 HOH A O 1 HETATM 4985 O O . HOH G 3 . ? 17.026 -0.047 -17.440 1.00 13.03 ? 802 HOH A O 1 HETATM 4986 O O . HOH G 3 . ? 16.672 16.998 6.652 1.00 19.48 ? 803 HOH A O 1 HETATM 4987 O O . HOH G 3 . ? 33.942 -3.229 13.614 1.00 16.18 ? 804 HOH A O 1 HETATM 4988 O O . HOH G 3 . ? 41.444 -4.657 -18.281 1.00 12.37 ? 805 HOH A O 1 HETATM 4989 O O . HOH G 3 . ? 41.852 -9.535 -26.760 1.00 11.02 ? 806 HOH A O 1 HETATM 4990 O O . HOH G 3 . ? 28.113 4.706 -18.225 1.00 20.05 ? 807 HOH A O 1 HETATM 4991 O O . HOH G 3 . ? 55.284 -0.594 -29.419 1.00 13.14 ? 808 HOH A O 1 HETATM 4992 O O . HOH G 3 . ? 38.711 -16.475 8.110 1.00 16.56 ? 809 HOH A O 1 HETATM 4993 O O . HOH G 3 . ? 62.348 -35.758 -17.411 1.00 14.86 ? 810 HOH A O 1 HETATM 4994 O O . HOH G 3 . ? 69.379 -24.580 -17.327 1.00 13.81 ? 811 HOH A O 1 HETATM 4995 O O . HOH G 3 . ? 23.239 -4.055 14.848 1.00 26.99 ? 812 HOH A O 1 HETATM 4996 O O . HOH G 3 . ? 44.210 -17.532 -29.292 1.00 22.70 ? 813 HOH A O 1 HETATM 4997 O O . HOH G 3 . ? 39.366 -5.476 -19.485 1.00 14.46 ? 814 HOH A O 1 HETATM 4998 O O . HOH G 3 . ? 44.093 4.400 -16.409 1.00 25.19 ? 815 HOH A O 1 HETATM 4999 O O . HOH G 3 . ? 65.175 -16.939 -22.515 1.00 15.55 ? 816 HOH A O 1 HETATM 5000 O O . HOH G 3 . ? 62.761 -8.640 -31.610 1.00 14.43 ? 817 HOH A O 1 HETATM 5001 O O . HOH G 3 . ? 21.277 15.936 -15.645 1.00 28.32 ? 818 HOH A O 1 HETATM 5002 O O . HOH G 3 . ? 51.269 -8.453 -36.553 1.00 18.46 ? 819 HOH A O 1 HETATM 5003 O O . HOH G 3 . ? 46.085 -12.279 -0.050 1.00 18.92 ? 820 HOH A O 1 HETATM 5004 O O . HOH G 3 . ? 71.226 -22.998 -23.687 1.00 13.22 ? 821 HOH A O 1 HETATM 5005 O O . HOH G 3 . ? 33.835 7.223 -18.210 1.00 19.81 ? 822 HOH A O 1 HETATM 5006 O O . HOH G 3 . ? 20.608 14.208 -13.209 1.00 19.99 ? 823 HOH A O 1 HETATM 5007 O O . HOH G 3 . ? 32.937 -8.477 8.406 1.00 13.63 ? 824 HOH A O 1 HETATM 5008 O O . HOH G 3 . ? 70.836 -19.756 -20.513 1.00 18.74 ? 825 HOH A O 1 HETATM 5009 O O . HOH G 3 . ? 17.912 19.581 9.196 1.00 26.25 ? 826 HOH A O 1 HETATM 5010 O O . HOH G 3 . ? 46.292 -7.172 2.121 1.00 17.10 ? 827 HOH A O 1 HETATM 5011 O O . HOH G 3 . ? 41.527 -10.708 -11.169 1.00 14.17 ? 828 HOH A O 1 HETATM 5012 O O . HOH G 3 . ? 35.577 -7.667 -16.830 1.00 19.74 ? 829 HOH A O 1 HETATM 5013 O O . HOH G 3 . ? 12.600 7.811 11.223 1.00 17.42 ? 830 HOH A O 1 HETATM 5014 O O . HOH G 3 . ? 69.459 -29.766 -30.601 1.00 21.48 ? 831 HOH A O 1 HETATM 5015 O O . HOH G 3 . ? 44.440 -15.755 -30.493 1.00 18.22 ? 832 HOH A O 1 HETATM 5016 O O . HOH G 3 . ? 72.300 -15.187 -9.905 1.00 13.29 ? 833 HOH A O 1 HETATM 5017 O O . HOH G 3 . ? 32.679 -19.681 1.133 1.00 23.72 ? 834 HOH A O 1 HETATM 5018 O O . HOH G 3 . ? 49.224 17.197 4.599 1.00 19.67 ? 835 HOH A O 1 HETATM 5019 O O . HOH G 3 . ? 8.531 -2.677 7.664 1.00 12.84 ? 836 HOH A O 1 HETATM 5020 O O . HOH G 3 . ? 64.893 -34.556 -16.724 1.00 7.99 ? 837 HOH A O 1 HETATM 5021 O O . HOH G 3 . ? 30.703 -3.650 13.384 1.00 21.13 ? 838 HOH A O 1 HETATM 5022 O O . HOH G 3 . ? 21.587 -7.316 4.334 1.00 22.67 ? 839 HOH A O 1 HETATM 5023 O O . HOH G 3 . ? 49.074 -4.030 -31.016 1.00 17.07 ? 840 HOH A O 1 HETATM 5024 O O . HOH G 3 . ? 50.789 -5.049 -3.894 1.00 13.22 ? 841 HOH A O 1 HETATM 5025 O O . HOH G 3 . ? 50.751 -0.497 -26.648 1.00 18.67 ? 842 HOH A O 1 HETATM 5026 O O . HOH G 3 . ? 46.578 14.082 -11.961 1.00 27.03 ? 843 HOH A O 1 HETATM 5027 O O . HOH G 3 . ? 48.192 -24.326 -4.283 1.00 21.17 ? 844 HOH A O 1 HETATM 5028 O O . HOH G 3 . ? 15.320 11.509 22.241 1.00 24.82 ? 845 HOH A O 1 HETATM 5029 O O . HOH G 3 . ? 66.998 -5.621 -23.179 1.00 27.18 ? 846 HOH A O 1 HETATM 5030 O O . HOH G 3 . ? 32.613 27.911 7.946 1.00 33.24 ? 847 HOH A O 1 HETATM 5031 O O . HOH G 3 . ? 55.175 -17.027 -36.874 1.00 18.88 ? 848 HOH A O 1 HETATM 5032 O O . HOH G 3 . ? 58.477 5.696 -20.406 1.00 19.38 ? 849 HOH A O 1 HETATM 5033 O O . HOH G 3 . ? 46.447 13.984 3.428 1.00 15.19 ? 850 HOH A O 1 HETATM 5034 O O . HOH G 3 . ? 33.881 7.624 -8.336 1.00 10.50 ? 851 HOH A O 1 HETATM 5035 O O . HOH G 3 . ? 66.032 -40.683 -21.167 1.00 31.72 ? 852 HOH A O 1 HETATM 5036 O O . HOH G 3 . ? 22.280 8.710 9.666 1.00 14.97 ? 853 HOH A O 1 HETATM 5037 O O . HOH G 3 . ? 16.484 6.518 -19.102 1.00 17.24 ? 854 HOH A O 1 HETATM 5038 O O . HOH G 3 . ? 25.605 -9.748 1.334 1.00 12.60 ? 855 HOH A O 1 HETATM 5039 O O . HOH G 3 . ? 73.723 -25.011 -19.589 1.00 32.74 ? 856 HOH A O 1 HETATM 5040 O O . HOH G 3 . ? 65.093 -7.246 -33.027 1.00 20.04 ? 857 HOH A O 1 HETATM 5041 O O . HOH G 3 . ? 9.645 0.034 19.296 1.00 27.59 ? 858 HOH A O 1 HETATM 5042 O O . HOH G 3 . ? 47.058 -32.207 -20.290 1.00 21.39 ? 859 HOH A O 1 HETATM 5043 O O . HOH G 3 . ? 25.642 25.866 8.098 1.00 25.40 ? 860 HOH A O 1 HETATM 5044 O O . HOH G 3 . ? 47.972 -0.319 -19.848 1.00 19.97 ? 861 HOH A O 1 HETATM 5045 O O . HOH G 3 . ? 33.702 10.343 -4.931 1.00 19.24 ? 862 HOH A O 1 HETATM 5046 O O . HOH G 3 . ? 39.908 -12.062 -24.355 1.00 14.21 ? 863 HOH A O 1 HETATM 5047 O O . HOH G 3 . ? 52.264 -37.719 -30.817 1.00 26.46 ? 864 HOH A O 1 HETATM 5048 O O . HOH G 3 . ? 14.861 15.914 -1.141 1.00 24.41 ? 865 HOH A O 1 HETATM 5049 O O . HOH G 3 . ? 34.209 -18.893 -20.598 1.00 24.82 ? 866 HOH A O 1 HETATM 5050 O O . HOH G 3 . ? 27.738 8.587 -18.527 1.00 17.98 ? 867 HOH A O 1 HETATM 5051 O O . HOH G 3 . ? 70.667 -36.133 -21.413 1.00 30.35 ? 868 HOH A O 1 HETATM 5052 O O . HOH G 3 . ? 28.742 -3.969 -20.114 1.00 18.58 ? 869 HOH A O 1 HETATM 5053 O O . HOH G 3 . ? 12.593 12.969 9.169 1.00 34.16 ? 870 HOH A O 1 HETATM 5054 O O . HOH G 3 . ? 53.340 -11.783 -40.899 1.00 27.06 ? 871 HOH A O 1 HETATM 5055 O O . HOH G 3 . ? 50.825 0.162 7.887 1.00 24.55 ? 872 HOH A O 1 HETATM 5056 O O . HOH G 3 . ? 49.538 -0.026 -33.041 1.00 21.83 ? 873 HOH A O 1 HETATM 5057 O O . HOH G 3 . ? 20.845 21.366 10.262 1.00 24.11 ? 874 HOH A O 1 HETATM 5058 O O . HOH G 3 . ? 36.564 -19.465 -29.049 1.00 29.27 ? 875 HOH A O 1 HETATM 5059 O O . HOH G 3 . ? 67.802 -19.447 -6.715 1.00 16.76 ? 876 HOH A O 1 HETATM 5060 O O . HOH G 3 . ? 18.049 16.531 16.067 1.00 28.36 ? 877 HOH A O 1 HETATM 5061 O O . HOH G 3 . ? 21.032 4.756 1.784 1.00 17.08 ? 878 HOH A O 1 HETATM 5062 O O . HOH G 3 . ? 36.675 -13.637 -23.335 1.00 26.58 ? 879 HOH A O 1 HETATM 5063 O O . HOH G 3 . ? 39.114 -17.655 0.772 1.00 23.54 ? 880 HOH A O 1 HETATM 5064 O O . HOH G 3 . ? 48.381 -8.150 4.072 1.00 22.12 ? 881 HOH A O 1 HETATM 5065 O O . HOH G 3 . ? 15.238 16.427 8.838 1.00 21.00 ? 882 HOH A O 1 HETATM 5066 O O . HOH G 3 . ? 33.867 -5.798 19.837 1.00 34.46 ? 883 HOH A O 1 HETATM 5067 O O . HOH G 3 . ? 7.766 13.041 1.628 1.00 23.31 ? 884 HOH A O 1 HETATM 5068 O O . HOH G 3 . ? 38.304 22.080 3.205 1.00 24.81 ? 885 HOH A O 1 HETATM 5069 O O . HOH G 3 . ? 40.933 -22.375 -3.894 1.00 21.41 ? 886 HOH A O 1 HETATM 5070 O O . HOH G 3 . ? 31.098 20.023 -6.193 1.00 20.48 ? 887 HOH A O 1 HETATM 5071 O O . HOH G 3 . ? 60.771 -3.364 -40.170 1.00 19.55 ? 888 HOH A O 1 HETATM 5072 O O . HOH G 3 . ? 59.148 11.960 2.606 1.00 28.40 ? 889 HOH A O 1 HETATM 5073 O O . HOH G 3 . ? 71.959 -25.936 -17.464 1.00 13.60 ? 890 HOH A O 1 HETATM 5074 O O . HOH G 3 . ? 51.017 4.118 13.299 1.00 25.78 ? 891 HOH A O 1 HETATM 5075 O O . HOH G 3 . ? 23.999 -0.268 9.292 1.00 17.88 ? 892 HOH A O 1 HETATM 5076 O O . HOH G 3 . ? 32.462 9.602 -14.388 1.00 34.24 ? 893 HOH A O 1 HETATM 5077 O O . HOH G 3 . ? 61.889 -17.183 -31.263 1.00 23.14 ? 894 HOH A O 1 HETATM 5078 O O . HOH G 3 . ? 47.285 -5.749 7.484 1.00 16.08 ? 895 HOH A O 1 HETATM 5079 O O . HOH G 3 . ? 37.481 6.287 -17.028 1.00 27.95 ? 896 HOH A O 1 HETATM 5080 O O . HOH G 3 . ? 33.808 14.201 -3.558 1.00 18.03 ? 897 HOH A O 1 HETATM 5081 O O . HOH G 3 . ? 58.077 -27.586 -36.405 1.00 33.90 ? 898 HOH A O 1 HETATM 5082 O O . HOH G 3 . ? 59.431 -39.276 -10.592 1.00 32.67 ? 899 HOH A O 1 HETATM 5083 O O . HOH G 3 . ? 9.753 5.464 8.559 1.00 28.87 ? 900 HOH A O 1 HETATM 5084 O O . HOH G 3 . ? 54.998 12.023 -3.587 1.00 17.16 ? 901 HOH A O 1 HETATM 5085 O O . HOH G 3 . ? 52.134 3.266 -29.356 1.00 21.49 ? 902 HOH A O 1 HETATM 5086 O O . HOH G 3 . ? 39.439 13.385 -6.695 1.00 18.38 ? 903 HOH A O 1 HETATM 5087 O O . HOH G 3 . ? 73.995 -31.836 -20.386 1.00 26.40 ? 904 HOH A O 1 HETATM 5088 O O . HOH G 3 . ? 28.388 -1.366 23.353 1.00 26.87 ? 905 HOH A O 1 HETATM 5089 O O . HOH G 3 . ? 33.059 -19.593 -18.468 1.00 28.75 ? 906 HOH A O 1 HETATM 5090 O O . HOH G 3 . ? 44.276 -8.682 -38.152 1.00 38.30 ? 907 HOH A O 1 HETATM 5091 O O . HOH G 3 . ? 67.745 -11.185 -13.790 1.00 24.22 ? 908 HOH A O 1 HETATM 5092 O O . HOH G 3 . ? 50.176 -4.996 2.423 1.00 19.75 ? 909 HOH A O 1 HETATM 5093 O O . HOH G 3 . ? 36.247 8.475 -17.866 1.00 43.14 ? 910 HOH A O 1 HETATM 5094 O O . HOH G 3 . ? 23.962 24.846 10.973 1.00 22.76 ? 911 HOH A O 1 HETATM 5095 O O . HOH G 3 . ? 40.870 4.870 -17.906 1.00 29.35 ? 912 HOH A O 1 HETATM 5096 O O . HOH G 3 . ? 6.824 -6.903 -11.324 1.00 39.33 ? 913 HOH A O 1 HETATM 5097 O O . HOH G 3 . ? 40.378 -4.746 19.618 1.00 26.38 ? 914 HOH A O 1 HETATM 5098 O O . HOH G 3 . ? 15.300 -7.027 -11.811 1.00 26.14 ? 915 HOH A O 1 HETATM 5099 O O . HOH G 3 . ? 37.517 11.794 -6.810 1.00 27.76 ? 916 HOH A O 1 HETATM 5100 O O . HOH G 3 . ? 55.488 -21.009 -3.880 1.00 35.94 ? 917 HOH A O 1 HETATM 5101 O O . HOH G 3 . ? 43.066 -17.331 2.108 1.00 19.22 ? 918 HOH A O 1 HETATM 5102 O O . HOH G 3 . ? 56.020 -13.717 -38.535 1.00 28.79 ? 919 HOH A O 1 HETATM 5103 O O . HOH G 3 . ? 37.714 -18.244 -1.685 1.00 17.92 ? 920 HOH A O 1 HETATM 5104 O O . HOH G 3 . ? 36.992 -20.814 -17.797 1.00 28.38 ? 921 HOH A O 1 HETATM 5105 O O . HOH G 3 . ? 59.450 -1.782 -12.439 1.00 18.66 ? 922 HOH A O 1 HETATM 5106 O O . HOH G 3 . ? 31.828 17.994 21.015 1.00 32.25 ? 923 HOH A O 1 HETATM 5107 O O . HOH G 3 . ? 54.040 -10.384 -49.087 1.00 30.89 ? 924 HOH A O 1 HETATM 5108 O O . HOH G 3 . ? 36.009 24.913 8.810 1.00 30.61 ? 925 HOH A O 1 HETATM 5109 O O . HOH G 3 . ? 49.740 6.907 17.652 1.00 30.08 ? 926 HOH A O 1 HETATM 5110 O O . HOH G 3 . ? 41.353 -6.683 -20.935 1.00 20.54 ? 927 HOH A O 1 HETATM 5111 O O . HOH G 3 . ? 22.019 -3.243 6.258 1.00 27.69 ? 928 HOH A O 1 HETATM 5112 O O . HOH G 3 . ? 57.069 5.814 -2.668 1.00 20.78 ? 929 HOH A O 1 HETATM 5113 O O . HOH G 3 . ? 34.436 -21.440 -17.066 1.00 16.99 ? 930 HOH A O 1 HETATM 5114 O O . HOH G 3 . ? 49.638 -6.245 -32.714 1.00 26.26 ? 931 HOH A O 1 HETATM 5115 O O . HOH G 3 . ? 40.650 12.832 -9.142 1.00 19.93 ? 932 HOH A O 1 HETATM 5116 O O . HOH G 3 . ? 40.872 -17.709 9.353 1.00 20.07 ? 933 HOH A O 1 HETATM 5117 O O . HOH G 3 . ? 39.101 28.533 8.969 1.00 28.22 ? 934 HOH A O 1 HETATM 5118 O O . HOH G 3 . ? 50.058 1.852 -28.543 1.00 26.19 ? 935 HOH A O 1 HETATM 5119 O O . HOH G 3 . ? 43.547 -5.464 -28.896 1.00 29.64 ? 936 HOH A O 1 HETATM 5120 O O . HOH G 3 . ? 47.411 -2.399 -26.670 1.00 18.87 ? 937 HOH A O 1 HETATM 5121 O O . HOH G 3 . ? 56.941 5.402 -0.032 1.00 27.59 ? 938 HOH A O 1 HETATM 5122 O O . HOH G 3 . ? 42.220 -15.679 10.678 1.00 15.39 ? 939 HOH A O 1 HETATM 5123 O O . HOH G 3 . ? 41.288 -12.656 -29.482 1.00 27.86 ? 940 HOH A O 1 HETATM 5124 O O . HOH G 3 . ? 53.590 -12.516 -4.681 1.00 18.54 ? 941 HOH A O 1 HETATM 5125 O O . HOH G 3 . ? 34.567 7.963 -13.105 1.00 18.73 ? 942 HOH A O 1 HETATM 5126 O O . HOH G 3 . ? 29.282 23.527 15.181 1.00 23.48 ? 943 HOH A O 1 HETATM 5127 O O . HOH G 3 . ? 14.301 -13.597 -11.465 1.00 31.29 ? 944 HOH A O 1 HETATM 5128 O O . HOH G 3 . ? 59.159 -38.928 -24.338 1.00 25.02 ? 945 HOH A O 1 HETATM 5129 O O . HOH G 3 . ? 54.764 13.497 1.146 1.00 29.45 ? 946 HOH A O 1 HETATM 5130 O O . HOH G 3 . ? 39.751 -31.230 -19.764 1.00 35.47 ? 947 HOH A O 1 HETATM 5131 O O . HOH G 3 . ? 63.234 -15.990 -33.510 1.00 16.65 ? 948 HOH A O 1 HETATM 5132 O O . HOH G 3 . ? 18.088 -3.160 9.106 1.00 26.50 ? 949 HOH A O 1 HETATM 5133 O O . HOH G 3 . ? 47.051 -32.252 -23.835 1.00 29.36 ? 950 HOH A O 1 HETATM 5134 O O . HOH G 3 . ? 38.507 -15.925 12.092 1.00 31.10 ? 951 HOH A O 1 HETATM 5135 O O . HOH G 3 . ? 41.476 1.494 18.002 1.00 15.54 ? 952 HOH A O 1 HETATM 5136 O O . HOH G 3 . ? 38.583 21.339 -4.170 1.00 29.64 ? 953 HOH A O 1 HETATM 5137 O O . HOH G 3 . ? 54.871 5.408 1.884 1.00 26.89 ? 954 HOH A O 1 HETATM 5138 O O . HOH G 3 . ? 71.449 -21.101 -7.826 1.00 33.00 ? 955 HOH A O 1 HETATM 5139 O O . HOH G 3 . ? 56.865 -39.994 -28.224 1.00 31.38 ? 956 HOH A O 1 HETATM 5140 O O . HOH G 3 . ? 65.148 -1.241 -21.417 1.00 25.72 ? 957 HOH A O 1 HETATM 5141 O O . HOH G 3 . ? 65.697 -4.323 -25.272 1.00 38.34 ? 958 HOH A O 1 HETATM 5142 O O . HOH G 3 . ? 27.445 -15.746 -4.455 1.00 22.97 ? 959 HOH A O 1 HETATM 5143 O O . HOH G 3 . ? 59.862 -23.180 -34.003 1.00 24.38 ? 960 HOH A O 1 HETATM 5144 O O . HOH G 3 . ? 46.703 -11.277 2.225 1.00 27.65 ? 961 HOH A O 1 HETATM 5145 O O . HOH G 3 . ? 57.653 -5.846 -7.731 1.00 29.84 ? 962 HOH A O 1 HETATM 5146 O O . HOH G 3 . ? 52.048 -9.170 -2.986 1.00 25.24 ? 963 HOH A O 1 HETATM 5147 O O . HOH G 3 . ? 62.623 -17.131 -35.765 1.00 40.38 ? 964 HOH A O 1 HETATM 5148 O O . HOH G 3 . ? 13.719 12.616 -16.596 1.00 22.94 ? 965 HOH A O 1 HETATM 5149 O O . HOH G 3 . ? 65.027 -35.765 -34.188 1.00 35.76 ? 966 HOH A O 1 HETATM 5150 O O . HOH G 3 . ? 16.769 5.828 -21.324 1.00 27.33 ? 967 HOH A O 1 HETATM 5151 O O . HOH G 3 . ? 56.447 3.876 -32.530 1.00 41.26 ? 968 HOH A O 1 HETATM 5152 O O . HOH G 3 . ? 59.337 -38.236 -17.691 1.00 21.99 ? 969 HOH A O 1 HETATM 5153 O O . HOH G 3 . ? 67.924 -16.719 -22.914 1.00 31.00 ? 970 HOH A O 1 HETATM 5154 O O . HOH G 3 . ? 38.160 -11.345 -11.937 1.00 28.62 ? 971 HOH A O 1 HETATM 5155 O O . HOH G 3 . ? 49.544 3.925 -18.381 1.00 26.03 ? 972 HOH A O 1 HETATM 5156 O O . HOH G 3 . ? 30.433 -16.398 -19.004 1.00 33.51 ? 973 HOH A O 1 HETATM 5157 O O . HOH G 3 . ? 10.889 11.759 8.993 1.00 46.48 ? 974 HOH A O 1 HETATM 5158 O O . HOH G 3 . ? 12.621 15.287 9.002 1.00 38.43 ? 975 HOH A O 1 HETATM 5159 O O . HOH G 3 . ? 42.835 16.368 -6.636 1.00 22.51 ? 976 HOH A O 1 HETATM 5160 O O . HOH G 3 . ? 70.032 -6.639 -21.041 1.00 33.48 ? 977 HOH A O 1 HETATM 5161 O O . HOH G 3 . ? 43.230 -3.407 -27.680 1.00 28.53 ? 978 HOH A O 1 HETATM 5162 O O . HOH G 3 . ? 62.213 1.279 -30.895 1.00 17.72 ? 979 HOH A O 1 HETATM 5163 O O . HOH G 3 . ? 22.149 21.163 12.685 1.00 17.29 ? 980 HOH A O 1 HETATM 5164 O O . HOH G 3 . ? 27.537 -12.218 -16.366 1.00 16.88 ? 981 HOH A O 1 HETATM 5165 O O . HOH G 3 . ? 49.612 -6.038 14.706 1.00 38.46 ? 982 HOH A O 1 HETATM 5166 O O . HOH G 3 . ? 44.782 -12.856 4.826 1.00 22.22 ? 983 HOH A O 1 HETATM 5167 O O . HOH G 3 . ? 28.132 20.087 17.951 1.00 28.78 ? 984 HOH A O 1 HETATM 5168 O O . HOH G 3 . ? 45.001 2.110 17.729 1.00 25.76 ? 985 HOH A O 1 HETATM 5169 O O . HOH G 3 . ? 51.060 -6.899 -1.798 1.00 18.72 ? 986 HOH A O 1 HETATM 5170 O O . HOH G 3 . ? 51.179 2.033 2.936 1.00 23.67 ? 987 HOH A O 1 HETATM 5171 O O . HOH G 3 . ? 23.569 27.241 1.934 1.00 27.45 ? 988 HOH A O 1 HETATM 5172 O O . HOH G 3 . ? 6.831 -2.921 -2.333 1.00 26.82 ? 989 HOH A O 1 HETATM 5173 O O . HOH G 3 . ? 73.855 -30.746 -13.231 1.00 21.70 ? 990 HOH A O 1 HETATM 5174 O O . HOH G 3 . ? 21.200 10.604 -19.509 1.00 28.57 ? 991 HOH A O 1 HETATM 5175 O O . HOH G 3 . ? 53.135 -24.817 -35.222 1.00 27.14 ? 992 HOH A O 1 HETATM 5176 O O . HOH G 3 . ? 17.824 3.587 21.119 1.00 32.28 ? 993 HOH A O 1 HETATM 5177 O O . HOH G 3 . ? 70.638 -23.333 -10.053 1.00 23.24 ? 994 HOH A O 1 HETATM 5178 O O . HOH G 3 . ? 52.841 6.387 -21.796 1.00 25.07 ? 995 HOH A O 1 HETATM 5179 O O . HOH G 3 . ? 23.669 17.746 -16.233 1.00 26.38 ? 996 HOH A O 1 HETATM 5180 O O . HOH G 3 . ? 40.632 17.824 -5.949 1.00 26.72 ? 997 HOH A O 1 HETATM 5181 O O . HOH G 3 . ? 16.325 9.158 22.963 1.00 30.71 ? 998 HOH A O 1 HETATM 5182 O O . HOH G 3 . ? 55.834 -38.468 -31.568 1.00 26.18 ? 999 HOH A O 1 HETATM 5183 O O . HOH G 3 . ? 51.057 -13.075 -3.866 1.00 20.93 ? 1000 HOH A O 1 HETATM 5184 O O . HOH G 3 . ? 39.888 -11.726 -33.507 1.00 36.52 ? 1001 HOH A O 1 HETATM 5185 O O . HOH G 3 . ? 50.479 4.209 16.475 1.00 23.44 ? 1002 HOH A O 1 HETATM 5186 O O . HOH G 3 . ? 66.322 -2.634 -14.619 1.00 34.08 ? 1003 HOH A O 1 HETATM 5187 O O . HOH G 3 . ? 20.241 -8.496 -14.411 1.00 24.02 ? 1004 HOH A O 1 HETATM 5188 O O . HOH G 3 . ? 22.481 10.592 23.948 1.00 24.10 ? 1005 HOH A O 1 HETATM 5189 O O . HOH G 3 . ? 55.557 -23.428 -33.925 1.00 23.60 ? 1006 HOH A O 1 HETATM 5190 O O . HOH G 3 . ? 26.939 -13.101 -11.037 1.00 27.35 ? 1007 HOH A O 1 HETATM 5191 O O . HOH G 3 . ? 25.791 -12.506 -14.165 1.00 32.77 ? 1008 HOH A O 1 HETATM 5192 O O . HOH G 3 . ? 39.217 -27.044 -13.848 1.00 28.59 ? 1009 HOH A O 1 HETATM 5193 O O . HOH G 3 . ? 56.001 6.428 4.289 1.00 26.88 ? 1010 HOH A O 1 HETATM 5194 O O . HOH G 3 . ? 18.727 2.147 -17.419 1.00 24.71 ? 1011 HOH A O 1 HETATM 5195 O O . HOH G 3 . ? 51.637 -15.350 -35.376 1.00 28.94 ? 1012 HOH A O 1 HETATM 5196 O O . HOH G 3 . ? 35.332 9.999 -8.015 1.00 33.90 ? 1013 HOH A O 1 HETATM 5197 O O . HOH G 3 . ? 55.729 9.783 -4.695 1.00 21.74 ? 1014 HOH A O 1 HETATM 5198 O O . HOH G 3 . ? 52.444 -3.122 -1.186 1.00 32.63 ? 1015 HOH A O 1 HETATM 5199 O O . HOH G 3 . ? 51.972 -4.748 -42.302 1.00 28.80 ? 1016 HOH A O 1 HETATM 5200 O O . HOH G 3 . ? 19.662 2.318 -20.406 1.00 30.12 ? 1017 HOH A O 1 HETATM 5201 O O . HOH G 3 . ? 43.062 19.034 0.582 1.00 24.78 ? 1018 HOH A O 1 HETATM 5202 O O . HOH G 3 . ? 61.924 -2.310 -35.828 1.00 28.74 ? 1019 HOH A O 1 HETATM 5203 O O . HOH G 3 . ? 61.917 -3.528 -12.665 1.00 27.41 ? 1020 HOH A O 1 # loop_ _pdbx_poly_seq_scheme.asym_id _pdbx_poly_seq_scheme.entity_id _pdbx_poly_seq_scheme.seq_id _pdbx_poly_seq_scheme.mon_id _pdbx_poly_seq_scheme.ndb_seq_num _pdbx_poly_seq_scheme.pdb_seq_num _pdbx_poly_seq_scheme.auth_seq_num _pdbx_poly_seq_scheme.pdb_mon_id _pdbx_poly_seq_scheme.auth_mon_id _pdbx_poly_seq_scheme.pdb_strand_id _pdbx_poly_seq_scheme.pdb_ins_code _pdbx_poly_seq_scheme.hetero A 1 1 LEU 1 1 1 LEU LEU A . n A 1 2 ALA 2 2 2 ALA ALA A . n A 1 3 PRO 3 3 3 PRO PRO A . n A 1 4 GLY 4 4 4 GLY GLY A . n A 1 5 SER 5 5 5 SER SER A . n A 1 6 SER 6 6 6 SER SER A . n A 1 7 ARG 7 7 7 ARG ARG A . n A 1 8 VAL 8 8 8 VAL VAL A . n A 1 9 GLU 9 9 9 GLU GLU A . n A 1 10 LEU 10 10 10 LEU LEU A . n A 1 11 PHE 11 11 11 PHE PHE A . n A 1 12 LYS 12 12 12 LYS LYS A . n A 1 13 ARG 13 13 13 ARG ARG A . n A 1 14 LYS 14 14 14 LYS LYS A . n A 1 15 ASN 15 15 15 ASN ASN A . n A 1 16 SER 16 16 16 SER SER A . n A 1 17 THR 17 17 17 THR THR A . n A 1 18 VAL 18 18 18 VAL VAL A . n A 1 19 PRO 19 19 19 PRO PRO A . n A 1 20 PHE 20 20 20 PHE PHE A . n A 1 21 GLU 21 21 21 GLU GLU A . n A 1 22 GLU 22 22 22 GLU GLU A . n A 1 23 SER 23 23 23 SER ALA A . n A 1 24 ASN 24 24 24 ASN ASN A . n A 1 25 GLY 25 25 25 GLY GLY A . n A 1 26 THR 26 26 26 THR THR A . n A 1 27 ILE 27 27 27 ILE ILE A . n A 1 28 ARG 28 28 28 ARG ALA A . n A 1 29 GLU 29 29 29 GLU GLU A . n A 1 30 ARG 30 30 30 ARG ARG A . n A 1 31 VAL 31 31 31 VAL ALA A . n A 1 32 VAL 32 32 32 VAL VAL A . n A 1 33 HIS 33 33 33 HIS HIS A . n A 1 34 SER 34 34 34 SER SER A . n A 1 35 PHE 35 35 35 PHE PHE A . n A 1 36 ARG 36 36 36 ARG ARG A . n A 1 37 ILE 37 37 37 ILE ILE A . n A 1 38 PRO 38 38 38 PRO PRO A . n A 1 39 THR 39 39 39 THR THR A . n A 1 40 ILE 40 40 40 ILE ILE A . n A 1 41 VAL 41 41 41 VAL VAL A . n A 1 42 ASN 42 42 42 ASN ASN A . n A 1 43 VAL 43 43 43 VAL VAL A . n A 1 44 ASP 44 44 44 ASP ASP A . n A 1 45 GLY 45 45 45 GLY GLY A . n A 1 46 VAL 46 46 46 VAL VAL A . n A 1 47 MET 47 47 47 MET MET A . n A 1 48 VAL 48 48 48 VAL VAL A . n A 1 49 ALA 49 49 49 ALA ALA A . n A 1 50 THR 50 50 50 THR THR A . n A 1 51 ALA 51 51 51 ALA ALA A . n A 1 52 ASP 52 52 52 ASP ASP A . n A 1 53 ALA 53 53 53 ALA ALA A . n A 1 54 ARG 54 54 54 ARG ARG A . n A 1 55 TYR 55 55 55 TYR TYR A . n A 1 56 GLU 56 56 56 GLU GLU A . n A 1 57 THR 57 57 57 THR THR A . n A 1 58 SER 58 58 58 SER SER A . n A 1 59 PHE 59 59 59 PHE PHE A . n A 1 60 ASP 60 60 60 ASP ASP A . n A 1 61 ASN 61 61 61 ASN ASN A . n A 1 62 SER 62 62 62 SER SER A . n A 1 63 PHE 63 63 63 PHE PHE A . n A 1 64 ILE 64 64 64 ILE ILE A . n A 1 65 GLU 65 65 65 GLU GLU A . n A 1 66 THR 66 66 66 THR THR A . n A 1 67 ALA 67 67 67 ALA ALA A . n A 1 68 VAL 68 68 68 VAL VAL A . n A 1 69 LYS 69 69 69 LYS LYS A . n A 1 70 TYR 70 70 70 TYR TYR A . n A 1 71 SER 71 71 71 SER SER A . n A 1 72 VAL 72 72 72 VAL VAL A . n A 1 73 ASP 73 73 73 ASP ASP A . n A 1 74 ASP 74 74 74 ASP ASP A . n A 1 75 GLY 75 75 75 GLY GLY A . n A 1 76 ALA 76 76 76 ALA ALA A . n A 1 77 THR 77 77 77 THR THR A . n A 1 78 TRP 78 78 78 TRP TRP A . n A 1 79 ASN 79 79 79 ASN ASN A . n A 1 80 THR 80 80 80 THR THR A . n A 1 81 GLN 81 81 81 GLN GLN A . n A 1 82 ILE 82 82 82 ILE ILE A . n A 1 83 ALA 83 83 83 ALA ALA A . n A 1 84 ILE 84 84 84 ILE ILE A . n A 1 85 LYS 85 85 85 LYS LYS A . n A 1 86 ASN 86 86 86 ASN ASN A . n A 1 87 SER 87 87 87 SER SER A . n A 1 88 ARG 88 88 88 ARG ARG A . n A 1 89 ALA 89 89 89 ALA ALA A . n A 1 90 SER 90 90 90 SER SER A . n A 1 91 SER 91 91 91 SER SER A . n A 1 92 VAL 92 92 92 VAL VAL A . n A 1 93 SER 93 93 93 SER SER A . n A 1 94 ARG 94 94 94 ARG ARG A . n A 1 95 VAL 95 95 95 VAL VAL A . n A 1 96 MET 96 96 96 MET MET A . n A 1 97 ASP 97 97 97 ASP ASP A . n A 1 98 ALA 98 98 98 ALA ALA A . n A 1 99 THR 99 99 99 THR THR A . n A 1 100 VAL 100 100 100 VAL VAL A . n A 1 101 ILE 101 101 101 ILE ILE A . n A 1 102 VAL 102 102 102 VAL VAL A . n A 1 103 LYS 103 103 103 LYS LYS A . n A 1 104 GLY 104 104 104 GLY GLY A . n A 1 105 ASN 105 105 105 ASN ASN A . n A 1 106 LYS 106 106 106 LYS LYS A . n A 1 107 LEU 107 107 107 LEU LEU A . n A 1 108 TYR 108 108 108 TYR TYR A . n A 1 109 ILE 109 109 109 ILE ILE A . n A 1 110 LEU 110 110 110 LEU LEU A . n A 1 111 VAL 111 111 111 VAL VAL A . n A 1 112 GLY 112 112 112 GLY GLY A . n A 1 113 SER 113 113 113 SER SER A . n A 1 114 PHE 114 114 114 PHE PHE A . n A 1 115 ASN 115 115 115 ASN ASN A . n A 1 116 LYS 116 116 116 LYS LYS A . n A 1 117 THR 117 117 117 THR THR A . n A 1 118 ARG 118 118 118 ARG ARG A . n A 1 119 ASN 119 119 119 ASN ASN A . n A 1 120 SER 120 120 120 SER SER A . n A 1 121 TRP 121 121 121 TRP TRP A . n A 1 122 THR 122 122 122 THR THR A . n A 1 123 GLN 123 123 123 GLN ALA A . n A 1 124 HIS 124 124 124 HIS HIS A . n A 1 125 ARG 125 125 125 ARG ALA A . n A 1 126 ASP 126 126 126 ASP ASP A . n A 1 127 GLY 127 127 127 GLY GLY A . n A 1 128 SER 128 128 128 SER SER A . n A 1 129 ASP 129 129 129 ASP ASP A . n A 1 130 TRP 130 130 130 TRP TRP A . n A 1 131 GLU 131 131 131 GLU GLU A . n A 1 132 PRO 132 132 132 PRO PRO A . n A 1 133 LEU 133 133 133 LEU LEU A . n A 1 134 LEU 134 134 134 LEU LEU A . n A 1 135 VAL 135 135 135 VAL VAL A . n A 1 136 VAL 136 136 136 VAL VAL A . n A 1 137 GLY 137 137 137 GLY GLY A . n A 1 138 GLU 138 138 138 GLU GLU A . n A 1 139 VAL 139 139 139 VAL VAL A . n A 1 140 THR 140 140 140 THR THR A . n A 1 141 LYS 141 141 141 LYS LYS A . n A 1 142 SER 142 142 142 SER SER A . n A 1 143 ALA 143 143 143 ALA ALA A . n A 1 144 ALA 144 144 144 ALA ALA A . n A 1 145 ASN 145 145 145 ASN ASN A . n A 1 146 GLY 146 146 146 GLY GLY A . n A 1 147 LYS 147 147 147 LYS LYS A . n A 1 148 THR 148 148 148 THR THR A . n A 1 149 THR 149 149 149 THR THR A . n A 1 150 ALA 150 150 150 ALA ALA A . n A 1 151 THR 151 151 151 THR THR A . n A 1 152 ILE 152 152 152 ILE ILE A . n A 1 153 SER 153 153 153 SER SER A . n A 1 154 TRP 154 154 154 TRP TRP A . n A 1 155 GLY 155 155 155 GLY GLY A . n A 1 156 LYS 156 156 156 LYS ALA A . n A 1 157 PRO 157 157 157 PRO PRO A . n A 1 158 VAL 158 158 158 VAL VAL A . n A 1 159 SER 159 159 159 SER SER A . n A 1 160 LEU 160 160 160 LEU LEU A . n A 1 161 LYS 161 161 161 LYS LYS A . n A 1 162 PRO 162 162 162 PRO PRO A . n A 1 163 LEU 163 163 163 LEU LEU A . n A 1 164 PHE 164 164 164 PHE PHE A . n A 1 165 PRO 165 165 165 PRO PRO A . n A 1 166 ALA 166 166 166 ALA ALA A . n A 1 167 GLU 167 167 167 GLU ALA A . n A 1 168 PHE 168 168 168 PHE PHE A . n A 1 169 ASP 169 169 169 ASP ASP A . n A 1 170 GLY 170 170 170 GLY GLY A . n A 1 171 ILE 171 171 171 ILE ILE A . n A 1 172 LEU 172 172 172 LEU LEU A . n A 1 173 THR 173 173 173 THR THR A . n A 1 174 LYS 174 174 174 LYS LYS A . n A 1 175 GLU 175 175 175 GLU GLU A . n A 1 176 PHE 176 176 176 PHE PHE A . n A 1 177 VAL 177 177 177 VAL VAL A . n A 1 178 GLY 178 178 178 GLY GLY A . n A 1 179 GLY 179 179 179 GLY GLY A . n A 1 180 VAL 180 180 180 VAL VAL A . n A 1 181 GLY 181 181 181 GLY GLY A . n A 1 182 ALA 182 182 182 ALA ALA A . n A 1 183 ALA 183 183 183 ALA ALA A . n A 1 184 ILE 184 184 184 ILE ILE A . n A 1 185 VAL 185 185 185 VAL VAL A . n A 1 186 GLY 186 186 186 GLY GLY A . n A 1 187 SER 187 187 187 SER SER A . n A 1 188 ASN 188 188 188 ASN ASN A . n A 1 189 GLY 189 189 189 GLY GLY A . n A 1 190 ASN 190 190 190 ASN ASN A . n A 1 191 LEU 191 191 191 LEU LEU A . n A 1 192 VAL 192 192 192 VAL VAL A . n A 1 193 TYR 193 193 193 TYR TYR A . n A 1 194 PRO 194 194 194 PRO PRO A . n A 1 195 VAL 195 195 195 VAL VAL A . n A 1 196 GLN 196 196 196 GLN GLN A . n A 1 197 ILE 197 197 197 ILE ILE A . n A 1 198 ALA 198 198 198 ALA ALA A . n A 1 199 ASP 199 199 199 ASP ASP A . n A 1 200 MET 200 200 200 MET MET A . n A 1 201 GLY 201 201 201 GLY GLY A . n A 1 202 GLY 202 202 202 GLY GLY A . n A 1 203 ARG 203 203 203 ARG ARG A . n A 1 204 VAL 204 204 204 VAL VAL A . n A 1 205 PHE 205 205 205 PHE PHE A . n A 1 206 THR 206 206 206 THR THR A . n A 1 207 LYS 207 207 207 LYS LYS A . n A 1 208 ILE 208 208 208 ILE ILE A . n A 1 209 MET 209 209 209 MET MET A . n A 1 210 TYR 210 210 210 TYR TYR A . n A 1 211 SER 211 211 211 SER SER A . n A 1 212 GLU 212 212 212 GLU GLU A . n A 1 213 ASP 213 213 213 ASP ASP A . n A 1 214 ASP 214 214 214 ASP ASP A . n A 1 215 GLY 215 215 215 GLY GLY A . n A 1 216 ASN 216 216 216 ASN ASN A . n A 1 217 THR 217 217 217 THR THR A . n A 1 218 TRP 218 218 218 TRP TRP A . n A 1 219 LYS 219 219 219 LYS LYS A . n A 1 220 PHE 220 220 220 PHE PHE A . n A 1 221 ALA 221 221 221 ALA ALA A . n A 1 222 GLU 222 222 222 GLU GLU A . n A 1 223 GLY 223 223 223 GLY GLY A . n A 1 224 ARG 224 224 224 ARG ARG A . n A 1 225 SER 225 225 225 SER SER A . n A 1 226 LYS 226 226 226 LYS LYS A . n A 1 227 PHE 227 227 227 PHE PHE A . n A 1 228 GLY 228 228 228 GLY GLY A . n A 1 229 CYS 229 229 229 CYS CYS A . n A 1 230 SER 230 230 230 SER SER A . n A 1 231 GLU 231 231 231 GLU GLU A . n A 1 232 PRO 232 232 232 PRO PRO A . n A 1 233 ALA 233 233 233 ALA ALA A . n A 1 234 VAL 234 234 234 VAL VAL A . n A 1 235 LEU 235 235 235 LEU LEU A . n A 1 236 GLU 236 236 236 GLU GLU A . n A 1 237 TRP 237 237 237 TRP TRP A . n A 1 238 GLU 238 238 238 GLU GLU A . n A 1 239 GLY 239 239 239 GLY GLY A . n A 1 240 LYS 240 240 240 LYS LYS A . n A 1 241 LEU 241 241 241 LEU LEU A . n A 1 242 ILE 242 242 242 ILE ILE A . n A 1 243 ILE 243 243 243 ILE ILE A . n A 1 244 ASN 244 244 244 ASN ASN A . n A 1 245 ASN 245 245 245 ASN ASN A . n A 1 246 ARG 246 246 246 ARG ARG A . n A 1 247 VAL 247 247 247 VAL VAL A . n A 1 248 ASP 248 248 248 ASP ASP A . n A 1 249 GLY 249 249 249 GLY GLY A . n A 1 250 ASN 250 250 250 ASN ASN A . n A 1 251 ARG 251 251 251 ARG ARG A . n A 1 252 ARG 252 252 252 ARG ARG A . n A 1 253 LEU 253 253 253 LEU LEU A . n A 1 254 VAL 254 254 254 VAL VAL A . n A 1 255 TYR 255 255 255 TYR TYR A . n A 1 256 GLU 256 256 256 GLU GLU A . n A 1 257 SER 257 257 257 SER SER A . n A 1 258 SER 258 258 258 SER SER A . n A 1 259 ASP 259 259 259 ASP ASP A . n A 1 260 MET 260 260 260 MET MET A . n A 1 261 GLY 261 261 261 GLY GLY A . n A 1 262 LYS 262 262 262 LYS LYS A . n A 1 263 THR 263 263 263 THR THR A . n A 1 264 TRP 264 264 264 TRP TRP A . n A 1 265 VAL 265 265 265 VAL VAL A . n A 1 266 GLU 266 266 266 GLU GLU A . n A 1 267 ALA 267 267 267 ALA ALA A . n A 1 268 LEU 268 268 268 LEU LEU A . n A 1 269 GLY 269 269 269 GLY GLY A . n A 1 270 THR 270 270 270 THR THR A . n A 1 271 LEU 271 271 271 LEU LEU A . n A 1 272 SER 272 272 272 SER SER A . n A 1 273 HIS 273 273 273 HIS HIS A . n A 1 274 VAL 274 274 274 VAL VAL A . n A 1 275 TRP 275 275 275 TRP TRP A . n A 1 276 THR 276 276 276 THR THR A . n A 1 277 ASN 277 277 277 ASN ASN A . n A 1 278 SER 278 278 278 SER SER A . n A 1 279 PRO 279 279 279 PRO PRO A . n A 1 280 THR 280 280 280 THR THR A . n A 1 281 SER 281 281 281 SER SER A . n A 1 282 ASN 282 282 282 ASN ASN A . n A 1 283 GLN 283 283 283 GLN GLN A . n A 1 284 GLN 284 284 284 GLN GLN A . n A 1 285 ASP 285 285 285 ASP ASP A . n A 1 286 CYS 286 286 286 CYS CYS A . n A 1 287 GLN 287 287 287 GLN GLN A . n A 1 288 SER 288 288 288 SER SER A . n A 1 289 SER 289 289 289 SER SER A . n A 1 290 PHE 290 290 290 PHE PHE A . n A 1 291 VAL 291 291 291 VAL VAL A . n A 1 292 ALA 292 292 292 ALA ALA A . n A 1 293 VAL 293 293 293 VAL VAL A . n A 1 294 THR 294 294 294 THR THR A . n A 1 295 ILE 295 295 295 ILE ILE A . n A 1 296 GLU 296 296 296 GLU GLU A . n A 1 297 GLY 297 297 297 GLY GLY A . n A 1 298 LYS 298 298 298 LYS LYS A . n A 1 299 ARG 299 299 299 ARG ARG A . n A 1 300 VAL 300 300 300 VAL VAL A . n A 1 301 MET 301 301 301 MET MET A . n A 1 302 LEU 302 302 302 LEU LEU A . n A 1 303 PHE 303 303 303 PHE PHE A . n A 1 304 THR 304 304 304 THR THR A . n A 1 305 HIS 305 305 305 HIS HIS A . n A 1 306 PRO 306 306 306 PRO PRO A . n A 1 307 LEU 307 307 307 LEU LEU A . n A 1 308 ASN 308 308 308 ASN ASN A . n A 1 309 LEU 309 309 309 LEU LEU A . n A 1 310 LYS 310 310 310 LYS LYS A . n A 1 311 GLY 311 311 311 GLY GLY A . n A 1 312 ARG 312 312 312 ARG ARG A . n A 1 313 TRP 313 313 313 TRP TRP A . n A 1 314 MET 314 314 314 MET MET A . n A 1 315 ARG 315 315 315 ARG ARG A . n A 1 316 ASP 316 316 316 ASP ASP A . n A 1 317 ARG 317 317 317 ARG ARG A . n A 1 318 LEU 318 318 318 LEU LEU A . n A 1 319 HIS 319 319 319 HIS HIS A . n A 1 320 LEU 320 320 320 LEU LEU A . n A 1 321 TRP 321 321 321 TRP TRP A . n A 1 322 MET 322 322 322 MET MET A . n A 1 323 THR 323 323 323 THR THR A . n A 1 324 ASP 324 324 324 ASP ASP A . n A 1 325 ASN 325 325 325 ASN ASN A . n A 1 326 GLN 326 326 326 GLN GLN A . n A 1 327 ARG 327 327 327 ARG ARG A . n A 1 328 ILE 328 328 328 ILE ILE A . n A 1 329 PHE 329 329 329 PHE PHE A . n A 1 330 ASP 330 330 330 ASP ASP A . n A 1 331 VAL 331 331 331 VAL VAL A . n A 1 332 GLY 332 332 332 GLY GLY A . n A 1 333 GLN 333 333 333 GLN GLN A . n A 1 334 ILE 334 334 334 ILE ILE A . n A 1 335 SER 335 335 335 SER SER A . n A 1 336 ILE 336 336 336 ILE ILE A . n A 1 337 GLY 337 337 337 GLY GLY A . n A 1 338 ASP 338 338 338 ASP ASP A . n A 1 339 GLU 339 339 339 GLU GLU A . n A 1 340 ASN 340 340 340 ASN ASN A . n A 1 341 SER 341 341 341 SER SER A . n A 1 342 GLY 342 342 342 GLY GLY A . n A 1 343 TYR 343 343 343 TYR TYR A . n A 1 344 SER 344 344 344 SER SER A . n A 1 345 SER 345 345 345 SER SER A . n A 1 346 VAL 346 346 346 VAL VAL A . n A 1 347 LEU 347 347 347 LEU LEU A . n A 1 348 TYR 348 348 348 TYR TYR A . n A 1 349 LYS 349 349 349 LYS LYS A . n A 1 350 ASP 350 350 350 ASP ASP A . n A 1 351 ASP 351 351 351 ASP ASP A . n A 1 352 LYS 352 352 352 LYS LYS A . n A 1 353 LEU 353 353 353 LEU LEU A . n A 1 354 TYR 354 354 354 TYR TYR A . n A 1 355 SER 355 355 355 SER SER A . n A 1 356 LEU 356 356 356 LEU LEU A . n A 1 357 HIS 357 357 357 HIS HIS A . n A 1 358 GLU 358 358 358 GLU GLU A . n A 1 359 ILE 359 359 359 ILE ILE A . n A 1 360 ASN 360 360 360 ASN ASN A . n A 1 361 THR 361 361 361 THR THR A . n A 1 362 ASN 362 362 362 ASN ASN A . n A 1 363 ASP 363 363 363 ASP ASP A . n A 1 364 VAL 364 364 364 VAL VAL A . n A 1 365 TYR 365 365 365 TYR TYR A . n A 1 366 SER 366 366 366 SER SER A . n A 1 367 LEU 367 367 367 LEU LEU A . n A 1 368 VAL 368 368 368 VAL VAL A . n A 1 369 PHE 369 369 369 PHE PHE A . n A 1 370 VAL 370 370 370 VAL VAL A . n A 1 371 ARG 371 371 371 ARG ARG A . n A 1 372 PHE 372 372 372 PHE PHE A . n A 1 373 ILE 373 373 373 ILE ILE A . n A 1 374 GLY 374 374 374 GLY GLY A . n A 1 375 GLU 375 375 375 GLU GLU A . n A 1 376 LEU 376 376 376 LEU LEU A . n A 1 377 GLN 377 377 377 GLN GLN A . n A 1 378 LEU 378 378 378 LEU LEU A . n A 1 379 MET 379 379 379 MET MET A . n A 1 380 LYS 380 380 380 LYS LYS A . n A 1 381 SER 381 381 381 SER SER A . n A 1 382 VAL 382 382 382 VAL VAL A . n A 1 383 VAL 383 383 383 VAL VAL A . n A 1 384 ARG 384 384 384 ARG ARG A . n A 1 385 THR 385 385 385 THR THR A . n A 1 386 TRP 386 386 386 TRP TRP A . n A 1 387 LYS 387 387 387 LYS LYS A . n A 1 388 GLU 388 388 388 GLU GLU A . n A 1 389 GLU 389 389 389 GLU GLU A . n A 1 390 ASP 390 390 390 ASP ASP A . n A 1 391 ASN 391 391 391 ASN ALA A . n A 1 392 HIS 392 392 392 HIS HIS A . n A 1 393 LEU 393 393 393 LEU LEU A . n A 1 394 ALA 394 394 394 ALA ALA A . n A 1 395 SER 395 395 395 SER SER A . n A 1 396 ILE 396 396 396 ILE ILE A . n A 1 397 CYS 397 397 397 CYS CYS A . n A 1 398 THR 398 398 398 THR THR A . n A 1 399 PRO 399 399 399 PRO PRO A . n A 1 400 VAL 400 400 400 VAL VAL A . n A 1 401 VAL 401 401 401 VAL VAL A . n A 1 402 PRO 402 402 402 PRO PRO A . n A 1 403 ALA 403 403 403 ALA ALA A . n A 1 404 THR 404 404 ? ? ? A . n A 1 405 PRO 405 405 ? ? ? A . n A 1 406 PRO 406 406 ? ? ? A . n A 1 407 SER 407 407 ? ? ? A . n A 1 408 LYS 408 408 ? ? ? A . n A 1 409 GLY 409 409 ? ? ? A . n A 1 410 GLY 410 410 410 GLY ALA A . n A 1 411 CYS 411 411 411 CYS CYS A . n A 1 412 GLY 412 412 412 GLY GLY A . n A 1 413 ALA 413 413 413 ALA ALA A . n A 1 414 ALA 414 414 414 ALA ALA A . n A 1 415 VAL 415 415 415 VAL VAL A . n A 1 416 PRO 416 416 416 PRO PRO A . n A 1 417 THR 417 417 417 THR THR A . n A 1 418 ALA 418 418 418 ALA ALA A . n A 1 419 GLY 419 419 419 GLY GLY A . n A 1 420 LEU 420 420 420 LEU LEU A . n A 1 421 VAL 421 421 421 VAL VAL A . n A 1 422 GLY 422 422 422 GLY GLY A . n A 1 423 PHE 423 423 423 PHE PHE A . n A 1 424 LEU 424 424 424 LEU LEU A . n A 1 425 SER 425 425 425 SER SER A . n A 1 426 HIS 426 426 426 HIS HIS A . n A 1 427 SER 427 427 427 SER SER A . n A 1 428 ALA 428 428 428 ALA ALA A . n A 1 429 ASN 429 429 429 ASN ASN A . n A 1 430 GLY 430 430 430 GLY GLY A . n A 1 431 SER 431 431 431 SER SER A . n A 1 432 VAL 432 432 432 VAL VAL A . n A 1 433 TRP 433 433 433 TRP TRP A . n A 1 434 GLU 434 434 434 GLU GLU A . n A 1 435 ASP 435 435 435 ASP ASP A . n A 1 436 VAL 436 436 436 VAL VAL A . n A 1 437 TYR 437 437 437 TYR TYR A . n A 1 438 ARG 438 438 438 ARG ARG A . n A 1 439 CYS 439 439 439 CYS CYS A . n A 1 440 VAL 440 440 440 VAL VAL A . n A 1 441 ASP 441 441 441 ASP ASP A . n A 1 442 ALA 442 442 442 ALA ALA A . n A 1 443 ASN 443 443 443 ASN ASN A . n A 1 444 VAL 444 444 444 VAL VAL A . n A 1 445 ALA 445 445 445 ALA ALA A . n A 1 446 ASN 446 446 446 ASN ASN A . n A 1 447 ALA 447 447 447 ALA ALA A . n A 1 448 GLU 448 448 448 GLU GLU A . n A 1 449 ARG 449 449 449 ARG ARG A . n A 1 450 VAL 450 450 450 VAL VAL A . n A 1 451 PRO 451 451 451 PRO PRO A . n A 1 452 ASN 452 452 452 ASN ASN A . n A 1 453 GLY 453 453 453 GLY GLY A . n A 1 454 LEU 454 454 454 LEU LEU A . n A 1 455 LYS 455 455 455 LYS LYS A . n A 1 456 PHE 456 456 456 PHE PHE A . n A 1 457 ASN 457 457 457 ASN ASN A . n A 1 458 GLY 458 458 458 GLY GLY A . n A 1 459 VAL 459 459 459 VAL VAL A . n A 1 460 GLY 460 460 460 GLY GLY A . n A 1 461 GLY 461 461 461 GLY GLY A . n A 1 462 GLY 462 462 462 GLY GLY A . n A 1 463 ALA 463 463 463 ALA ALA A . n A 1 464 VAL 464 464 464 VAL VAL A . n A 1 465 TRP 465 465 465 TRP TRP A . n A 1 466 PRO 466 466 466 PRO PRO A . n A 1 467 VAL 467 467 467 VAL VAL A . n A 1 468 ALA 468 468 468 ALA ALA A . n A 1 469 ARG 469 469 469 ARG ARG A . n A 1 470 GLN 470 470 470 GLN GLN A . n A 1 471 GLY 471 471 471 GLY GLY A . n A 1 472 GLN 472 472 472 GLN GLN A . n A 1 473 THR 473 473 473 THR THR A . n A 1 474 ARG 474 474 474 ARG ARG A . n A 1 475 ARG 475 475 475 ARG ARG A . n A 1 476 TYR 476 476 476 TYR TYR A . n A 1 477 GLN 477 477 477 GLN GLN A . n A 1 478 PHE 478 478 478 PHE PHE A . n A 1 479 ALA 479 479 479 ALA ALA A . n A 1 480 ASN 480 480 480 ASN ASN A . n A 1 481 TYR 481 481 481 TYR TYR A . n A 1 482 ARG 482 482 482 ARG ARG A . n A 1 483 PHE 483 483 483 PHE PHE A . n A 1 484 THR 484 484 484 THR THR A . n A 1 485 LEU 485 485 485 LEU LEU A . n A 1 486 VAL 486 486 486 VAL VAL A . n A 1 487 ALA 487 487 487 ALA ALA A . n A 1 488 THR 488 488 488 THR THR A . n A 1 489 VAL 489 489 489 VAL VAL A . n A 1 490 THR 490 490 490 THR THR A . n A 1 491 ILE 491 491 491 ILE ILE A . n A 1 492 ASP 492 492 492 ASP ASP A . n A 1 493 GLU 493 493 493 GLU GLU A . n A 1 494 LEU 494 494 494 LEU LEU A . n A 1 495 PRO 495 495 495 PRO PRO A . n A 1 496 LYS 496 496 496 LYS LYS A . n A 1 497 GLY 497 497 497 GLY GLY A . n A 1 498 THR 498 498 498 THR THR A . n A 1 499 SER 499 499 499 SER SER A . n A 1 500 PRO 500 500 500 PRO PRO A . n A 1 501 LEU 501 501 501 LEU LEU A . n A 1 502 LEU 502 502 502 LEU LEU A . n A 1 503 GLY 503 503 503 GLY GLY A . n A 1 504 ALA 504 504 504 ALA ALA A . n A 1 505 GLY 505 505 505 GLY GLY A . n A 1 506 LEU 506 506 506 LEU LEU A . n A 1 507 GLU 507 507 507 GLU GLU A . n A 1 508 GLY 508 508 508 GLY GLY A . n A 1 509 PRO 509 509 509 PRO PRO A . n A 1 510 GLY 510 510 510 GLY GLY A . n A 1 511 ASP 511 511 511 ASP ASP A . n A 1 512 ALA 512 512 512 ALA ALA A . n A 1 513 LYS 513 513 513 LYS LYS A . n A 1 514 LEU 514 514 514 LEU LEU A . n A 1 515 LEU 515 515 515 LEU LEU A . n A 1 516 GLY 516 516 516 GLY GLY A . n A 1 517 LEU 517 517 517 LEU LEU A . n A 1 518 SER 518 518 518 SER SER A . n A 1 519 TYR 519 519 519 TYR TYR A . n A 1 520 ASP 520 520 520 ASP ASP A . n A 1 521 LYS 521 521 521 LYS LYS A . n A 1 522 ASN 522 522 522 ASN ASN A . n A 1 523 ARG 523 523 523 ARG ARG A . n A 1 524 GLN 524 524 524 GLN GLN A . n A 1 525 TRP 525 525 525 TRP TRP A . n A 1 526 ARG 526 526 526 ARG ARG A . n A 1 527 PRO 527 527 527 PRO PRO A . n A 1 528 LEU 528 528 528 LEU LEU A . n A 1 529 TYR 529 529 529 TYR TYR A . n A 1 530 GLY 530 530 530 GLY GLY A . n A 1 531 ALA 531 531 531 ALA ALA A . n A 1 532 ALA 532 532 532 ALA ALA A . n A 1 533 PRO 533 533 533 PRO PRO A . n A 1 534 ALA 534 534 534 ALA ALA A . n A 1 535 SER 535 535 535 SER SER A . n A 1 536 PRO 536 536 536 PRO PRO A . n A 1 537 THR 537 537 537 THR THR A . n A 1 538 GLY 538 538 538 GLY GLY A . n A 1 539 SER 539 539 539 SER SER A . n A 1 540 TRP 540 540 540 TRP TRP A . n A 1 541 GLU 541 541 541 GLU ALA A . n A 1 542 LEU 542 542 542 LEU LEU A . n A 1 543 HIS 543 543 543 HIS HIS A . n A 1 544 LYS 544 544 544 LYS LYS A . n A 1 545 LYS 545 545 545 LYS ALA A . n A 1 546 TYR 546 546 546 TYR TYR A . n A 1 547 HIS 547 547 547 HIS HIS A . n A 1 548 VAL 548 548 548 VAL VAL A . n A 1 549 VAL 549 549 549 VAL VAL A . n A 1 550 LEU 550 550 550 LEU LEU A . n A 1 551 THR 551 551 551 THR THR A . n A 1 552 MET 552 552 552 MET MET A . n A 1 553 ALA 553 553 553 ALA ALA A . n A 1 554 ASP 554 554 554 ASP ASP A . n A 1 555 ARG 555 555 555 ARG ARG A . n A 1 556 GLN 556 556 556 GLN GLN A . n A 1 557 GLY 557 557 557 GLY GLY A . n A 1 558 SER 558 558 558 SER SER A . n A 1 559 VAL 559 559 559 VAL VAL A . n A 1 560 TYR 560 560 560 TYR TYR A . n A 1 561 VAL 561 561 561 VAL VAL A . n A 1 562 ASP 562 562 562 ASP ASP A . n A 1 563 GLY 563 563 563 GLY GLY A . n A 1 564 GLN 564 564 564 GLN GLN A . n A 1 565 PRO 565 565 565 PRO PRO A . n A 1 566 LEU 566 566 566 LEU LEU A . n A 1 567 ALA 567 567 567 ALA ALA A . n A 1 568 GLY 568 568 568 GLY GLY A . n A 1 569 SER 569 569 569 SER SER A . n A 1 570 GLY 570 570 570 GLY GLY A . n A 1 571 ASN 571 571 571 ASN ASN A . n A 1 572 THR 572 572 572 THR THR A . n A 1 573 VAL 573 573 573 VAL VAL A . n A 1 574 VAL 574 574 574 VAL VAL A . n A 1 575 ARG 575 575 575 ARG ARG A . n A 1 576 GLY 576 576 576 GLY GLY A . n A 1 577 ALA 577 577 577 ALA ALA A . n A 1 578 THR 578 578 578 THR THR A . n A 1 579 LEU 579 579 579 LEU LEU A . n A 1 580 PRO 580 580 580 PRO PRO A . n A 1 581 ASP 581 581 581 ASP ASP A . n A 1 582 ILE 582 582 582 ILE ILE A . n A 1 583 SER 583 583 583 SER SER A . n A 1 584 HIS 584 584 584 HIS HIS A . n A 1 585 PHE 585 585 585 PHE PHE A . n A 1 586 TYR 586 586 586 TYR TYR A . n A 1 587 ILE 587 587 587 ILE ILE A . n A 1 588 GLY 588 588 588 GLY GLY A . n A 1 589 GLY 589 589 589 GLY GLY A . n A 1 590 PRO 590 590 590 PRO PRO A . n A 1 591 ARG 591 591 ? ? ? A . n A 1 592 SER 592 592 ? ? ? A . n A 1 593 LYS 593 593 ? ? ? A . n A 1 594 GLY 594 594 594 GLY GLY A . n A 1 595 ALA 595 595 595 ALA ALA A . n A 1 596 PRO 596 596 596 PRO PRO A . n A 1 597 THR 597 597 597 THR THR A . n A 1 598 ASP 598 598 598 ASP ASP A . n A 1 599 SER 599 599 599 SER SER A . n A 1 600 ARG 600 600 600 ARG ARG A . n A 1 601 VAL 601 601 601 VAL VAL A . n A 1 602 THR 602 602 602 THR THR A . n A 1 603 VAL 603 603 603 VAL VAL A . n A 1 604 THR 604 604 604 THR THR A . n A 1 605 ASN 605 605 605 ASN ASN A . n A 1 606 ILE 606 606 606 ILE ILE A . n A 1 607 VAL 607 607 607 VAL VAL A . n A 1 608 LEU 608 608 608 LEU LEU A . n A 1 609 TYR 609 609 609 TYR TYR A . n A 1 610 ASN 610 610 610 ASN ASN A . n A 1 611 ARG 611 611 611 ARG ARG A . n A 1 612 ARG 612 612 612 ARG ARG A . n A 1 613 LEU 613 613 613 LEU LEU A . n A 1 614 ASN 614 614 614 ASN ASN A . n A 1 615 SER 615 615 615 SER SER A . n A 1 616 SER 616 616 616 SER SER A . n A 1 617 GLU 617 617 617 GLU GLU A . n A 1 618 ILE 618 618 618 ILE ILE A . n A 1 619 ARG 619 619 619 ARG ARG A . n A 1 620 THR 620 620 620 THR THR A . n A 1 621 LEU 621 621 621 LEU LEU A . n A 1 622 PHE 622 622 622 PHE PHE A . n A 1 623 LEU 623 623 623 LEU LEU A . n A 1 624 SER 624 624 624 SER SER A . n A 1 625 GLN 625 625 625 GLN GLN A . n A 1 626 ASP 626 626 626 ASP ASP A . n A 1 627 MET 627 627 627 MET MET A . n A 1 628 ILE 628 628 628 ILE ILE A . n A 1 629 GLY 629 629 629 GLY GLY A . n A 1 630 THR 630 630 630 THR THR A . n A 1 631 ASP 631 631 631 ASP ALA A . n A 1 632 GLY 632 632 ? ? ? A . n A 1 633 GLY 633 633 ? ? ? A . n A 1 634 ALA 634 634 ? ? ? A . n A 1 635 GLY 635 635 ? ? ? A . n A 1 636 THR 636 636 ? ? ? A . n A 1 637 ALA 637 637 ? ? ? A . n A 1 638 ALA 638 638 ? ? ? A . n # loop_ _pdbx_struct_mod_residue.id _pdbx_struct_mod_residue.label_asym_id _pdbx_struct_mod_residue.label_comp_id _pdbx_struct_mod_residue.label_seq_id _pdbx_struct_mod_residue.auth_asym_id _pdbx_struct_mod_residue.auth_comp_id _pdbx_struct_mod_residue.auth_seq_id _pdbx_struct_mod_residue.PDB_ins_code _pdbx_struct_mod_residue.parent_comp_id _pdbx_struct_mod_residue.details 1 A ASN 15 A ASN 15 ? ASN 'GLYCOSYLATION SITE' 2 A ASN 24 A ASN 24 ? ASN 'GLYCOSYLATION SITE' 3 A ASN 115 A ASN 115 ? ASN 'GLYCOSYLATION SITE' 4 A ASN 429 A ASN 429 ? ASN 'GLYCOSYLATION SITE' 5 A ASN 614 A ASN 614 ? ASN 'GLYCOSYLATION SITE' # _pdbx_struct_assembly.id 1 _pdbx_struct_assembly.details author_defined_assembly _pdbx_struct_assembly.method_details ? _pdbx_struct_assembly.oligomeric_details monomeric _pdbx_struct_assembly.oligomeric_count 1 # _pdbx_struct_assembly_gen.assembly_id 1 _pdbx_struct_assembly_gen.oper_expression 1 _pdbx_struct_assembly_gen.asym_id_list A,B,C,D,E,F,G # _pdbx_struct_oper_list.id 1 _pdbx_struct_oper_list.type 'identity operation' _pdbx_struct_oper_list.name 1_555 _pdbx_struct_oper_list.symmetry_operation x,y,z _pdbx_struct_oper_list.matrix[1][1] 1.0000000000 _pdbx_struct_oper_list.matrix[1][2] 0.0000000000 _pdbx_struct_oper_list.matrix[1][3] 0.0000000000 _pdbx_struct_oper_list.vector[1] 0.0000000000 _pdbx_struct_oper_list.matrix[2][1] 0.0000000000 _pdbx_struct_oper_list.matrix[2][2] 1.0000000000 _pdbx_struct_oper_list.matrix[2][3] 0.0000000000 _pdbx_struct_oper_list.vector[2] 0.0000000000 _pdbx_struct_oper_list.matrix[3][1] 0.0000000000 _pdbx_struct_oper_list.matrix[3][2] 0.0000000000 _pdbx_struct_oper_list.matrix[3][3] 1.0000000000 _pdbx_struct_oper_list.vector[3] 0.0000000000 # loop_ _pdbx_audit_revision_history.ordinal _pdbx_audit_revision_history.data_content_type _pdbx_audit_revision_history.major_revision _pdbx_audit_revision_history.minor_revision _pdbx_audit_revision_history.revision_date 1 'Structure model' 1 0 2002-10-16 2 'Structure model' 1 1 2008-04-28 3 'Structure model' 1 2 2011-07-13 # _pdbx_audit_revision_details.ordinal 1 _pdbx_audit_revision_details.revision_ordinal 1 _pdbx_audit_revision_details.data_content_type 'Structure model' _pdbx_audit_revision_details.provider repository _pdbx_audit_revision_details.type 'Initial release' _pdbx_audit_revision_details.description ? # loop_ _pdbx_audit_revision_group.ordinal _pdbx_audit_revision_group.revision_ordinal _pdbx_audit_revision_group.data_content_type _pdbx_audit_revision_group.group 1 2 'Structure model' 'Version format compliance' 2 3 'Structure model' 'Non-polymer description' 3 3 'Structure model' 'Version format compliance' # loop_ _software.name _software.classification _software.version _software.citation_id _software.pdbx_ordinal DENZO 'data reduction' . ? 1 SCALEPACK 'data scaling' . ? 2 AMoRE phasing '+ MLPHARE' ? 3 REFMAC refinement 5.0 ? 4 MLPHARE phasing . ? 5 # loop_ _pdbx_validate_close_contact.id _pdbx_validate_close_contact.PDB_model_num _pdbx_validate_close_contact.auth_atom_id_1 _pdbx_validate_close_contact.auth_asym_id_1 _pdbx_validate_close_contact.auth_comp_id_1 _pdbx_validate_close_contact.auth_seq_id_1 _pdbx_validate_close_contact.PDB_ins_code_1 _pdbx_validate_close_contact.label_alt_id_1 _pdbx_validate_close_contact.auth_atom_id_2 _pdbx_validate_close_contact.auth_asym_id_2 _pdbx_validate_close_contact.auth_comp_id_2 _pdbx_validate_close_contact.auth_seq_id_2 _pdbx_validate_close_contact.PDB_ins_code_2 _pdbx_validate_close_contact.label_alt_id_2 _pdbx_validate_close_contact.dist 1 1 O A HOH 870 ? ? O A HOH 974 ? ? 2.10 2 1 O A HOH 813 ? ? O A HOH 832 ? ? 2.16 3 1 OD1 A ASP 259 ? ? CG2 A THR 263 ? ? 2.18 4 1 O6 A NAG 655 ? ? O A HOH 936 ? ? 2.19 # loop_ _pdbx_validate_symm_contact.id _pdbx_validate_symm_contact.PDB_model_num _pdbx_validate_symm_contact.auth_atom_id_1 _pdbx_validate_symm_contact.auth_asym_id_1 _pdbx_validate_symm_contact.auth_comp_id_1 _pdbx_validate_symm_contact.auth_seq_id_1 _pdbx_validate_symm_contact.PDB_ins_code_1 _pdbx_validate_symm_contact.label_alt_id_1 _pdbx_validate_symm_contact.site_symmetry_1 _pdbx_validate_symm_contact.auth_atom_id_2 _pdbx_validate_symm_contact.auth_asym_id_2 _pdbx_validate_symm_contact.auth_comp_id_2 _pdbx_validate_symm_contact.auth_seq_id_2 _pdbx_validate_symm_contact.PDB_ins_code_2 _pdbx_validate_symm_contact.label_alt_id_2 _pdbx_validate_symm_contact.site_symmetry_2 _pdbx_validate_symm_contact.dist 1 1 O A HOH 889 ? ? 1_555 O A HOH 924 ? ? 2_655 2.16 2 1 O A HOH 857 ? ? 1_555 O A HOH 926 ? ? 2_654 2.18 # loop_ _pdbx_validate_rmsd_angle.id _pdbx_validate_rmsd_angle.PDB_model_num _pdbx_validate_rmsd_angle.auth_atom_id_1 _pdbx_validate_rmsd_angle.auth_asym_id_1 _pdbx_validate_rmsd_angle.auth_comp_id_1 _pdbx_validate_rmsd_angle.auth_seq_id_1 _pdbx_validate_rmsd_angle.PDB_ins_code_1 _pdbx_validate_rmsd_angle.label_alt_id_1 _pdbx_validate_rmsd_angle.auth_atom_id_2 _pdbx_validate_rmsd_angle.auth_asym_id_2 _pdbx_validate_rmsd_angle.auth_comp_id_2 _pdbx_validate_rmsd_angle.auth_seq_id_2 _pdbx_validate_rmsd_angle.PDB_ins_code_2 _pdbx_validate_rmsd_angle.label_alt_id_2 _pdbx_validate_rmsd_angle.auth_atom_id_3 _pdbx_validate_rmsd_angle.auth_asym_id_3 _pdbx_validate_rmsd_angle.auth_comp_id_3 _pdbx_validate_rmsd_angle.auth_seq_id_3 _pdbx_validate_rmsd_angle.PDB_ins_code_3 _pdbx_validate_rmsd_angle.label_alt_id_3 _pdbx_validate_rmsd_angle.angle_value _pdbx_validate_rmsd_angle.angle_target_value _pdbx_validate_rmsd_angle.angle_deviation _pdbx_validate_rmsd_angle.angle_standard_deviation _pdbx_validate_rmsd_angle.linker_flag 1 1 NE A ARG 7 ? ? CZ A ARG 7 ? ? NH2 A ARG 7 ? ? 117.18 120.30 -3.12 0.50 N 2 1 CB A ASP 60 ? ? CG A ASP 60 ? ? OD2 A ASP 60 ? ? 124.14 118.30 5.84 0.90 N 3 1 CB A ASP 129 ? ? CG A ASP 129 ? ? OD2 A ASP 129 ? ? 124.90 118.30 6.60 0.90 N 4 1 CB A ASP 169 ? ? CG A ASP 169 ? ? OD2 A ASP 169 ? ? 124.05 118.30 5.75 0.90 N 5 1 CB A ASP 248 ? ? CG A ASP 248 ? ? OD2 A ASP 248 ? ? 124.71 118.30 6.41 0.90 N 6 1 NE A ARG 251 ? ? CZ A ARG 251 ? ? NH1 A ARG 251 ? ? 116.50 120.30 -3.80 0.50 N 7 1 CB A ASP 350 ? ? CG A ASP 350 ? ? OD2 A ASP 350 ? ? 125.21 118.30 6.91 0.90 N 8 1 CB A ASP 492 ? ? CG A ASP 492 ? ? OD2 A ASP 492 ? ? 125.19 118.30 6.89 0.90 N 9 1 CB A LEU 506 ? ? CG A LEU 506 ? ? CD1 A LEU 506 ? ? 100.08 111.00 -10.92 1.70 N 10 1 N A ASP 511 ? ? CA A ASP 511 ? ? CB A ASP 511 ? ? 99.69 110.60 -10.91 1.80 N 11 1 CB A ASP 562 ? ? CG A ASP 562 ? ? OD2 A ASP 562 ? ? 124.96 118.30 6.66 0.90 N # loop_ _pdbx_validate_torsion.id _pdbx_validate_torsion.PDB_model_num _pdbx_validate_torsion.auth_comp_id _pdbx_validate_torsion.auth_asym_id _pdbx_validate_torsion.auth_seq_id _pdbx_validate_torsion.PDB_ins_code _pdbx_validate_torsion.label_alt_id _pdbx_validate_torsion.phi _pdbx_validate_torsion.psi 1 1 LYS A 14 ? ? 39.20 44.03 2 1 ASN A 15 ? ? -160.27 -65.99 3 1 ASN A 61 ? ? -100.70 54.11 4 1 SER A 142 ? ? -98.07 -130.23 5 1 ALA A 143 ? ? 161.49 -154.26 6 1 ASN A 145 ? ? -38.83 92.77 7 1 LYS A 174 ? ? -123.33 -57.00 8 1 VAL A 180 ? ? 90.16 119.30 9 1 ALA A 183 ? ? -113.64 -156.91 10 1 GLU A 231 ? ? 27.21 62.30 11 1 THR A 270 ? ? -139.20 -74.17 12 1 SER A 278 ? ? 175.17 165.36 13 1 HIS A 305 ? ? -172.49 141.39 14 1 ARG A 312 ? ? 54.08 -134.36 15 1 ARG A 317 ? ? 60.54 67.41 16 1 GLN A 326 ? ? -130.98 -66.28 17 1 SER A 341 ? ? -107.80 -118.31 18 1 SER A 425 ? ? -136.77 -122.84 19 1 VAL A 467 ? ? -116.48 -93.85 20 1 PRO A 596 ? ? -80.84 44.68 21 1 ASN A 610 ? ? -92.37 30.42 # loop_ _pdbx_unobs_or_zero_occ_atoms.id _pdbx_unobs_or_zero_occ_atoms.PDB_model_num _pdbx_unobs_or_zero_occ_atoms.polymer_flag _pdbx_unobs_or_zero_occ_atoms.occupancy_flag _pdbx_unobs_or_zero_occ_atoms.auth_asym_id _pdbx_unobs_or_zero_occ_atoms.auth_comp_id _pdbx_unobs_or_zero_occ_atoms.auth_seq_id _pdbx_unobs_or_zero_occ_atoms.PDB_ins_code _pdbx_unobs_or_zero_occ_atoms.auth_atom_id _pdbx_unobs_or_zero_occ_atoms.label_alt_id _pdbx_unobs_or_zero_occ_atoms.label_asym_id _pdbx_unobs_or_zero_occ_atoms.label_comp_id _pdbx_unobs_or_zero_occ_atoms.label_seq_id _pdbx_unobs_or_zero_occ_atoms.label_atom_id 1 1 Y 1 A SER 23 ? OG ? A SER 23 OG 2 1 Y 1 A ARG 28 ? CG ? A ARG 28 CG 3 1 Y 1 A ARG 28 ? CD ? A ARG 28 CD 4 1 Y 1 A ARG 28 ? NE ? A ARG 28 NE 5 1 Y 1 A ARG 28 ? CZ ? A ARG 28 CZ 6 1 Y 1 A ARG 28 ? NH1 ? A ARG 28 NH1 7 1 Y 1 A ARG 28 ? NH2 ? A ARG 28 NH2 8 1 Y 1 A VAL 31 ? CG1 ? A VAL 31 CG1 9 1 Y 1 A VAL 31 ? CG2 ? A VAL 31 CG2 10 1 Y 1 A GLN 123 ? CG ? A GLN 123 CG 11 1 Y 1 A GLN 123 ? CD ? A GLN 123 CD 12 1 Y 1 A GLN 123 ? OE1 ? A GLN 123 OE1 13 1 Y 1 A GLN 123 ? NE2 ? A GLN 123 NE2 14 1 Y 1 A ARG 125 ? CG ? A ARG 125 CG 15 1 Y 1 A ARG 125 ? CD ? A ARG 125 CD 16 1 Y 1 A ARG 125 ? NE ? A ARG 125 NE 17 1 Y 1 A ARG 125 ? CZ ? A ARG 125 CZ 18 1 Y 1 A ARG 125 ? NH1 ? A ARG 125 NH1 19 1 Y 1 A ARG 125 ? NH2 ? A ARG 125 NH2 20 1 Y 1 A LYS 156 ? CG ? A LYS 156 CG 21 1 Y 1 A LYS 156 ? CD ? A LYS 156 CD 22 1 Y 1 A LYS 156 ? CE ? A LYS 156 CE 23 1 Y 1 A LYS 156 ? NZ ? A LYS 156 NZ 24 1 Y 1 A GLU 167 ? CG ? A GLU 167 CG 25 1 Y 1 A GLU 167 ? CD ? A GLU 167 CD 26 1 Y 1 A GLU 167 ? OE1 ? A GLU 167 OE1 27 1 Y 1 A GLU 167 ? OE2 ? A GLU 167 OE2 28 1 Y 1 A ASN 391 ? CG ? A ASN 391 CG 29 1 Y 1 A ASN 391 ? OD1 ? A ASN 391 OD1 30 1 Y 1 A ASN 391 ? ND2 ? A ASN 391 ND2 31 1 Y 1 A GLU 541 ? CG ? A GLU 541 CG 32 1 Y 1 A GLU 541 ? CD ? A GLU 541 CD 33 1 Y 1 A GLU 541 ? OE1 ? A GLU 541 OE1 34 1 Y 1 A GLU 541 ? OE2 ? A GLU 541 OE2 35 1 Y 1 A LYS 545 ? CG ? A LYS 545 CG 36 1 Y 1 A LYS 545 ? CD ? A LYS 545 CD 37 1 Y 1 A LYS 545 ? CE ? A LYS 545 CE 38 1 Y 1 A LYS 545 ? NZ ? A LYS 545 NZ 39 1 Y 1 A ASP 631 ? CG ? A ASP 631 CG 40 1 Y 1 A ASP 631 ? OD1 ? A ASP 631 OD1 41 1 Y 1 A ASP 631 ? OD2 ? A ASP 631 OD2 # loop_ _pdbx_unobs_or_zero_occ_residues.id _pdbx_unobs_or_zero_occ_residues.PDB_model_num _pdbx_unobs_or_zero_occ_residues.polymer_flag _pdbx_unobs_or_zero_occ_residues.occupancy_flag _pdbx_unobs_or_zero_occ_residues.auth_asym_id _pdbx_unobs_or_zero_occ_residues.auth_comp_id _pdbx_unobs_or_zero_occ_residues.auth_seq_id _pdbx_unobs_or_zero_occ_residues.PDB_ins_code _pdbx_unobs_or_zero_occ_residues.label_asym_id _pdbx_unobs_or_zero_occ_residues.label_comp_id _pdbx_unobs_or_zero_occ_residues.label_seq_id 1 1 Y 1 A THR 404 ? A THR 404 2 1 Y 1 A PRO 405 ? A PRO 405 3 1 Y 1 A PRO 406 ? A PRO 406 4 1 Y 1 A SER 407 ? A SER 407 5 1 Y 1 A LYS 408 ? A LYS 408 6 1 Y 1 A GLY 409 ? A GLY 409 7 1 Y 1 A ARG 591 ? A ARG 591 8 1 Y 1 A SER 592 ? A SER 592 9 1 Y 1 A LYS 593 ? A LYS 593 10 1 Y 1 A GLY 632 ? A GLY 632 11 1 Y 1 A GLY 633 ? A GLY 633 12 1 Y 1 A ALA 634 ? A ALA 634 13 1 Y 1 A GLY 635 ? A GLY 635 14 1 Y 1 A THR 636 ? A THR 636 15 1 Y 1 A ALA 637 ? A ALA 637 16 1 Y 1 A ALA 638 ? A ALA 638 # loop_ _pdbx_entity_nonpoly.entity_id _pdbx_entity_nonpoly.name _pdbx_entity_nonpoly.comp_id 2 N-ACETYL-D-GLUCOSAMINE NAG 3 water HOH # loop_ _pdbx_nonpoly_scheme.asym_id _pdbx_nonpoly_scheme.entity_id _pdbx_nonpoly_scheme.mon_id _pdbx_nonpoly_scheme.ndb_seq_num _pdbx_nonpoly_scheme.pdb_seq_num _pdbx_nonpoly_scheme.auth_seq_num _pdbx_nonpoly_scheme.pdb_mon_id _pdbx_nonpoly_scheme.auth_mon_id _pdbx_nonpoly_scheme.pdb_strand_id _pdbx_nonpoly_scheme.pdb_ins_code B 2 NAG 1 651 651 NAG NAG A . C 2 NAG 1 652 652 NAG NAG A . D 2 NAG 1 653 653 NAG NAG A . E 2 NAG 1 654 654 NAG NAG A . F 2 NAG 1 655 655 NAG NAG A . G 3 HOH 1 656 1 HOH HOH A . G 3 HOH 2 657 2 HOH HOH A . G 3 HOH 3 658 3 HOH HOH A . G 3 HOH 4 659 4 HOH HOH A . G 3 HOH 5 660 5 HOH HOH A . G 3 HOH 6 661 6 HOH HOH A . G 3 HOH 7 662 7 HOH HOH A . G 3 HOH 8 663 8 HOH HOH A . G 3 HOH 9 664 9 HOH HOH A . G 3 HOH 10 665 10 HOH HOH A . G 3 HOH 11 666 11 HOH HOH A . G 3 HOH 12 667 12 HOH HOH A . G 3 HOH 13 668 13 HOH HOH A . G 3 HOH 14 669 14 HOH HOH A . G 3 HOH 15 670 15 HOH HOH A . G 3 HOH 16 671 16 HOH HOH A . G 3 HOH 17 672 17 HOH HOH A . G 3 HOH 18 673 18 HOH HOH A . G 3 HOH 19 674 19 HOH HOH A . G 3 HOH 20 675 20 HOH HOH A . G 3 HOH 21 676 21 HOH HOH A . G 3 HOH 22 677 22 HOH HOH A . G 3 HOH 23 678 23 HOH HOH A . G 3 HOH 24 679 24 HOH HOH A . G 3 HOH 25 680 25 HOH HOH A . G 3 HOH 26 681 26 HOH HOH A . G 3 HOH 27 682 27 HOH HOH A . G 3 HOH 28 683 28 HOH HOH A . G 3 HOH 29 684 29 HOH HOH A . G 3 HOH 30 685 30 HOH HOH A . G 3 HOH 31 686 31 HOH HOH A . G 3 HOH 32 687 32 HOH HOH A . G 3 HOH 33 688 33 HOH HOH A . G 3 HOH 34 689 34 HOH HOH A . G 3 HOH 35 690 35 HOH HOH A . G 3 HOH 36 691 36 HOH HOH A . G 3 HOH 37 692 37 HOH HOH A . G 3 HOH 38 693 38 HOH HOH A . G 3 HOH 39 694 39 HOH HOH A . G 3 HOH 40 695 40 HOH HOH A . G 3 HOH 41 696 41 HOH HOH A . G 3 HOH 42 697 42 HOH HOH A . G 3 HOH 43 698 43 HOH HOH A . G 3 HOH 44 699 44 HOH HOH A . G 3 HOH 45 700 45 HOH HOH A . G 3 HOH 46 701 46 HOH HOH A . G 3 HOH 47 702 47 HOH HOH A . G 3 HOH 48 703 48 HOH HOH A . G 3 HOH 49 704 49 HOH HOH A . G 3 HOH 50 705 50 HOH HOH A . G 3 HOH 51 706 51 HOH HOH A . G 3 HOH 52 707 52 HOH HOH A . G 3 HOH 53 708 53 HOH HOH A . G 3 HOH 54 709 54 HOH HOH A . G 3 HOH 55 710 55 HOH HOH A . G 3 HOH 56 711 56 HOH HOH A . G 3 HOH 57 712 57 HOH HOH A . G 3 HOH 58 713 58 HOH HOH A . G 3 HOH 59 714 59 HOH HOH A . G 3 HOH 60 715 60 HOH HOH A . G 3 HOH 61 716 61 HOH HOH A . G 3 HOH 62 717 62 HOH HOH A . G 3 HOH 63 718 63 HOH HOH A . G 3 HOH 64 719 64 HOH HOH A . G 3 HOH 65 720 65 HOH HOH A . G 3 HOH 66 721 66 HOH HOH A . G 3 HOH 67 722 67 HOH HOH A . G 3 HOH 68 723 68 HOH HOH A . G 3 HOH 69 724 69 HOH HOH A . G 3 HOH 70 725 70 HOH HOH A . G 3 HOH 71 726 71 HOH HOH A . G 3 HOH 72 727 72 HOH HOH A . G 3 HOH 73 728 73 HOH HOH A . G 3 HOH 74 729 74 HOH HOH A . G 3 HOH 75 730 75 HOH HOH A . G 3 HOH 76 731 76 HOH HOH A . G 3 HOH 77 732 77 HOH HOH A . G 3 HOH 78 733 78 HOH HOH A . G 3 HOH 79 734 79 HOH HOH A . G 3 HOH 80 735 80 HOH HOH A . G 3 HOH 81 736 81 HOH HOH A . G 3 HOH 82 737 82 HOH HOH A . G 3 HOH 83 738 83 HOH HOH A . G 3 HOH 84 739 84 HOH HOH A . G 3 HOH 85 740 85 HOH HOH A . G 3 HOH 86 741 86 HOH HOH A . G 3 HOH 87 742 87 HOH HOH A . G 3 HOH 88 743 88 HOH HOH A . G 3 HOH 89 744 89 HOH HOH A . G 3 HOH 90 745 90 HOH HOH A . G 3 HOH 91 746 91 HOH HOH A . G 3 HOH 92 747 92 HOH HOH A . G 3 HOH 93 748 93 HOH HOH A . G 3 HOH 94 749 94 HOH HOH A . G 3 HOH 95 750 95 HOH HOH A . G 3 HOH 96 751 96 HOH HOH A . G 3 HOH 97 752 97 HOH HOH A . G 3 HOH 98 753 98 HOH HOH A . G 3 HOH 99 754 99 HOH HOH A . G 3 HOH 100 755 100 HOH HOH A . G 3 HOH 101 756 101 HOH HOH A . G 3 HOH 102 757 102 HOH HOH A . G 3 HOH 103 758 103 HOH HOH A . G 3 HOH 104 759 104 HOH HOH A . G 3 HOH 105 760 105 HOH HOH A . G 3 HOH 106 761 106 HOH HOH A . G 3 HOH 107 762 107 HOH HOH A . G 3 HOH 108 763 108 HOH HOH A . G 3 HOH 109 764 109 HOH HOH A . G 3 HOH 110 765 110 HOH HOH A . G 3 HOH 111 766 111 HOH HOH A . G 3 HOH 112 767 112 HOH HOH A . G 3 HOH 113 768 113 HOH HOH A . G 3 HOH 114 769 114 HOH HOH A . G 3 HOH 115 770 115 HOH HOH A . G 3 HOH 116 771 116 HOH HOH A . G 3 HOH 117 772 117 HOH HOH A . G 3 HOH 118 773 118 HOH HOH A . G 3 HOH 119 774 119 HOH HOH A . G 3 HOH 120 775 120 HOH HOH A . G 3 HOH 121 776 121 HOH HOH A . G 3 HOH 122 777 122 HOH HOH A . G 3 HOH 123 778 123 HOH HOH A . G 3 HOH 124 779 124 HOH HOH A . G 3 HOH 125 780 125 HOH HOH A . G 3 HOH 126 781 126 HOH HOH A . G 3 HOH 127 782 127 HOH HOH A . G 3 HOH 128 783 128 HOH HOH A . G 3 HOH 129 784 129 HOH HOH A . G 3 HOH 130 785 130 HOH HOH A . G 3 HOH 131 786 131 HOH HOH A . G 3 HOH 132 787 132 HOH HOH A . G 3 HOH 133 788 133 HOH HOH A . G 3 HOH 134 789 134 HOH HOH A . G 3 HOH 135 790 135 HOH HOH A . G 3 HOH 136 791 136 HOH HOH A . G 3 HOH 137 792 137 HOH HOH A . G 3 HOH 138 793 138 HOH HOH A . G 3 HOH 139 794 139 HOH HOH A . G 3 HOH 140 795 140 HOH HOH A . G 3 HOH 141 796 141 HOH HOH A . G 3 HOH 142 797 142 HOH HOH A . G 3 HOH 143 798 143 HOH HOH A . G 3 HOH 144 799 144 HOH HOH A . G 3 HOH 145 800 145 HOH HOH A . G 3 HOH 146 801 146 HOH HOH A . G 3 HOH 147 802 147 HOH HOH A . G 3 HOH 148 803 148 HOH HOH A . G 3 HOH 149 804 149 HOH HOH A . G 3 HOH 150 805 150 HOH HOH A . G 3 HOH 151 806 151 HOH HOH A . G 3 HOH 152 807 152 HOH HOH A . G 3 HOH 153 808 153 HOH HOH A . G 3 HOH 154 809 154 HOH HOH A . G 3 HOH 155 810 155 HOH HOH A . G 3 HOH 156 811 156 HOH HOH A . G 3 HOH 157 812 157 HOH HOH A . G 3 HOH 158 813 158 HOH HOH A . G 3 HOH 159 814 159 HOH HOH A . G 3 HOH 160 815 160 HOH HOH A . G 3 HOH 161 816 161 HOH HOH A . G 3 HOH 162 817 162 HOH HOH A . G 3 HOH 163 818 163 HOH HOH A . G 3 HOH 164 819 164 HOH HOH A . G 3 HOH 165 820 165 HOH HOH A . G 3 HOH 166 821 166 HOH HOH A . G 3 HOH 167 822 167 HOH HOH A . G 3 HOH 168 823 168 HOH HOH A . G 3 HOH 169 824 169 HOH HOH A . G 3 HOH 170 825 170 HOH HOH A . G 3 HOH 171 826 171 HOH HOH A . G 3 HOH 172 827 172 HOH HOH A . G 3 HOH 173 828 173 HOH HOH A . G 3 HOH 174 829 174 HOH HOH A . G 3 HOH 175 830 175 HOH HOH A . G 3 HOH 176 831 176 HOH HOH A . G 3 HOH 177 832 177 HOH HOH A . G 3 HOH 178 833 178 HOH HOH A . G 3 HOH 179 834 179 HOH HOH A . G 3 HOH 180 835 180 HOH HOH A . G 3 HOH 181 836 181 HOH HOH A . G 3 HOH 182 837 182 HOH HOH A . G 3 HOH 183 838 183 HOH HOH A . G 3 HOH 184 839 184 HOH HOH A . G 3 HOH 185 840 185 HOH HOH A . G 3 HOH 186 841 186 HOH HOH A . G 3 HOH 187 842 187 HOH HOH A . G 3 HOH 188 843 188 HOH HOH A . G 3 HOH 189 844 189 HOH HOH A . G 3 HOH 190 845 190 HOH HOH A . G 3 HOH 191 846 191 HOH HOH A . G 3 HOH 192 847 192 HOH HOH A . G 3 HOH 193 848 193 HOH HOH A . G 3 HOH 194 849 194 HOH HOH A . G 3 HOH 195 850 195 HOH HOH A . G 3 HOH 196 851 196 HOH HOH A . G 3 HOH 197 852 197 HOH HOH A . G 3 HOH 198 853 198 HOH HOH A . G 3 HOH 199 854 199 HOH HOH A . G 3 HOH 200 855 200 HOH HOH A . G 3 HOH 201 856 201 HOH HOH A . G 3 HOH 202 857 202 HOH HOH A . G 3 HOH 203 858 203 HOH HOH A . G 3 HOH 204 859 204 HOH HOH A . G 3 HOH 205 860 205 HOH HOH A . G 3 HOH 206 861 206 HOH HOH A . G 3 HOH 207 862 207 HOH HOH A . G 3 HOH 208 863 208 HOH HOH A . G 3 HOH 209 864 209 HOH HOH A . G 3 HOH 210 865 210 HOH HOH A . G 3 HOH 211 866 211 HOH HOH A . G 3 HOH 212 867 212 HOH HOH A . G 3 HOH 213 868 213 HOH HOH A . G 3 HOH 214 869 214 HOH HOH A . G 3 HOH 215 870 215 HOH HOH A . G 3 HOH 216 871 216 HOH HOH A . G 3 HOH 217 872 217 HOH HOH A . G 3 HOH 218 873 218 HOH HOH A . G 3 HOH 219 874 219 HOH HOH A . G 3 HOH 220 875 220 HOH HOH A . G 3 HOH 221 876 221 HOH HOH A . G 3 HOH 222 877 222 HOH HOH A . G 3 HOH 223 878 223 HOH HOH A . G 3 HOH 224 879 224 HOH HOH A . G 3 HOH 225 880 225 HOH HOH A . G 3 HOH 226 881 226 HOH HOH A . G 3 HOH 227 882 227 HOH HOH A . G 3 HOH 228 883 228 HOH HOH A . G 3 HOH 229 884 229 HOH HOH A . G 3 HOH 230 885 230 HOH HOH A . G 3 HOH 231 886 231 HOH HOH A . G 3 HOH 232 887 232 HOH HOH A . G 3 HOH 233 888 233 HOH HOH A . G 3 HOH 234 889 234 HOH HOH A . G 3 HOH 235 890 235 HOH HOH A . G 3 HOH 236 891 236 HOH HOH A . G 3 HOH 237 892 237 HOH HOH A . G 3 HOH 238 893 238 HOH HOH A . G 3 HOH 239 894 239 HOH HOH A . G 3 HOH 240 895 240 HOH HOH A . G 3 HOH 241 896 241 HOH HOH A . G 3 HOH 242 897 242 HOH HOH A . G 3 HOH 243 898 243 HOH HOH A . G 3 HOH 244 899 244 HOH HOH A . G 3 HOH 245 900 245 HOH HOH A . G 3 HOH 246 901 246 HOH HOH A . G 3 HOH 247 902 247 HOH HOH A . G 3 HOH 248 903 248 HOH HOH A . G 3 HOH 249 904 249 HOH HOH A . G 3 HOH 250 905 250 HOH HOH A . G 3 HOH 251 906 251 HOH HOH A . G 3 HOH 252 907 252 HOH HOH A . G 3 HOH 253 908 253 HOH HOH A . G 3 HOH 254 909 254 HOH HOH A . G 3 HOH 255 910 255 HOH HOH A . G 3 HOH 256 911 256 HOH HOH A . G 3 HOH 257 912 257 HOH HOH A . G 3 HOH 258 913 258 HOH HOH A . G 3 HOH 259 914 259 HOH HOH A . G 3 HOH 260 915 260 HOH HOH A . G 3 HOH 261 916 261 HOH HOH A . G 3 HOH 262 917 262 HOH HOH A . G 3 HOH 263 918 263 HOH HOH A . G 3 HOH 264 919 264 HOH HOH A . G 3 HOH 265 920 265 HOH HOH A . G 3 HOH 266 921 266 HOH HOH A . G 3 HOH 267 922 267 HOH HOH A . G 3 HOH 268 923 268 HOH HOH A . G 3 HOH 269 924 269 HOH HOH A . G 3 HOH 270 925 270 HOH HOH A . G 3 HOH 271 926 271 HOH HOH A . G 3 HOH 272 927 272 HOH HOH A . G 3 HOH 273 928 273 HOH HOH A . G 3 HOH 274 929 274 HOH HOH A . G 3 HOH 275 930 275 HOH HOH A . G 3 HOH 276 931 276 HOH HOH A . G 3 HOH 277 932 277 HOH HOH A . G 3 HOH 278 933 278 HOH HOH A . G 3 HOH 279 934 279 HOH HOH A . G 3 HOH 280 935 280 HOH HOH A . G 3 HOH 281 936 281 HOH HOH A . G 3 HOH 282 937 282 HOH HOH A . G 3 HOH 283 938 283 HOH HOH A . G 3 HOH 284 939 284 HOH HOH A . G 3 HOH 285 940 285 HOH HOH A . G 3 HOH 286 941 286 HOH HOH A . G 3 HOH 287 942 287 HOH HOH A . G 3 HOH 288 943 288 HOH HOH A . G 3 HOH 289 944 289 HOH HOH A . G 3 HOH 290 945 290 HOH HOH A . G 3 HOH 291 946 291 HOH HOH A . G 3 HOH 292 947 292 HOH HOH A . G 3 HOH 293 948 293 HOH HOH A . G 3 HOH 294 949 294 HOH HOH A . G 3 HOH 295 950 295 HOH HOH A . G 3 HOH 296 951 296 HOH HOH A . G 3 HOH 297 952 297 HOH HOH A . G 3 HOH 298 953 298 HOH HOH A . G 3 HOH 299 954 299 HOH HOH A . G 3 HOH 300 955 300 HOH HOH A . G 3 HOH 301 956 301 HOH HOH A . G 3 HOH 302 957 302 HOH HOH A . G 3 HOH 303 958 303 HOH HOH A . G 3 HOH 304 959 304 HOH HOH A . G 3 HOH 305 960 305 HOH HOH A . G 3 HOH 306 961 306 HOH HOH A . G 3 HOH 307 962 307 HOH HOH A . G 3 HOH 308 963 308 HOH HOH A . G 3 HOH 309 964 309 HOH HOH A . G 3 HOH 310 965 310 HOH HOH A . G 3 HOH 311 966 311 HOH HOH A . G 3 HOH 312 967 312 HOH HOH A . G 3 HOH 313 968 313 HOH HOH A . G 3 HOH 314 969 314 HOH HOH A . G 3 HOH 315 970 315 HOH HOH A . G 3 HOH 316 971 316 HOH HOH A . G 3 HOH 317 972 317 HOH HOH A . G 3 HOH 318 973 318 HOH HOH A . G 3 HOH 319 974 319 HOH HOH A . G 3 HOH 320 975 320 HOH HOH A . G 3 HOH 321 976 321 HOH HOH A . G 3 HOH 322 977 322 HOH HOH A . G 3 HOH 323 978 323 HOH HOH A . G 3 HOH 324 979 324 HOH HOH A . G 3 HOH 325 980 325 HOH HOH A . G 3 HOH 326 981 326 HOH HOH A . G 3 HOH 327 982 327 HOH HOH A . G 3 HOH 328 983 328 HOH HOH A . G 3 HOH 329 984 329 HOH HOH A . G 3 HOH 330 985 330 HOH HOH A . G 3 HOH 331 986 331 HOH HOH A . G 3 HOH 332 987 332 HOH HOH A . G 3 HOH 333 988 333 HOH HOH A . G 3 HOH 334 989 334 HOH HOH A . G 3 HOH 335 990 335 HOH HOH A . G 3 HOH 336 991 336 HOH HOH A . G 3 HOH 337 992 337 HOH HOH A . G 3 HOH 338 993 338 HOH HOH A . G 3 HOH 339 994 339 HOH HOH A . G 3 HOH 340 995 340 HOH HOH A . G 3 HOH 341 996 341 HOH HOH A . G 3 HOH 342 997 342 HOH HOH A . G 3 HOH 343 998 343 HOH HOH A . G 3 HOH 344 999 344 HOH HOH A . G 3 HOH 345 1000 345 HOH HOH A . G 3 HOH 346 1001 346 HOH HOH A . G 3 HOH 347 1002 347 HOH HOH A . G 3 HOH 348 1003 348 HOH HOH A . G 3 HOH 349 1004 349 HOH HOH A . G 3 HOH 350 1005 350 HOH HOH A . G 3 HOH 351 1006 351 HOH HOH A . G 3 HOH 352 1007 352 HOH HOH A . G 3 HOH 353 1008 353 HOH HOH A . G 3 HOH 354 1009 354 HOH HOH A . G 3 HOH 355 1010 355 HOH HOH A . G 3 HOH 356 1011 356 HOH HOH A . G 3 HOH 357 1012 357 HOH HOH A . G 3 HOH 358 1013 358 HOH HOH A . G 3 HOH 359 1014 359 HOH HOH A . G 3 HOH 360 1015 360 HOH HOH A . G 3 HOH 361 1016 361 HOH HOH A . G 3 HOH 362 1017 362 HOH HOH A . G 3 HOH 363 1018 363 HOH HOH A . G 3 HOH 364 1019 364 HOH HOH A . G 3 HOH 365 1020 365 HOH HOH A . #