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Innov Aging
Innov Aging
innovateage
Innovation in Aging
2399-5300 Oxford University Press US 

10.1093/geroni/igaa057.1672
igaa057.1672
Abstracts
Session 3018 (Symposium)
ESPO/ Biological Sciences Section Symposium: Understanding the Complex and Interconnected Pathways of Aging
AcademicSubjects/SOC02600
Differences in Longitudinal Fasting Blood Glucose and Mortality Risk Across the Lifespan Between Mice and Humans
Palliyaguru Dushani  Shiroma Eric  Nam John  Ferrucci Luigi  de Cabo Rafael  SLAM Investigators  
National Institute on Aging, Bethesda, Maryland, United States
2020 
16 12 2020 
16 12 2020 
4 Suppl 1 Program Abstracts from The GSA 2020 Annual Scientific Meeting “Turning 75: Why Age Matters”518 518
© The Author(s) 2020. Published by Oxford University Press on behalf of The Gerontological Society of America.2020This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.Abstract
Aging profoundly affects metabolism where trajectories of metabolic indices serve as strong predictors of health, disease and mortality. Mice and non-human primates are widely used to model all aspects of human biology, including metabolism. However, there is limited knowledge on how different species metabolically age during their life course. Here, we compare longitudinal predictors of health and mortality of three major metabolic indices among mice, non-human primates and humans. Longitudinal fasting blood glucose, body weight and body composition over the lifespan were compared across species in mice (Study of Longitudinal Aging in Mice), Rhesus monkeys (NIA and Wisconsin colonies) and humans (Baltimore Longitudinal Study on Aging). Survival analysis was conducted to calculate the risk of death for subjects with highest and lowest quartiles of fasting blood glucose. We will present data highlighting species-specific mechanisms of glucose homeostasis over the lifespan and its association with mortality.