==== Front Innov Aging Innov Aging innovateage Innovation in Aging 2399-5300 Oxford University Press US 10.1093/geroni/igaa057.2295 igaa057.2295 Abstracts Session 5950 (Symposium) AcademicSubjects/SOC02600 Gender-Specific Determinants of Instrumental Activities and Associations With Cognitive Decline in TILDA McGarrigle Christine 1 Donoghue Orna A 2 Orr Joanna 2 Kenny Rose Anne 2 1 Trinity College Dublin, Dublin, Ireland 2 The Irish Longitudinal Study on Ageing (TILDA), Dublin, Dublin, Ireland 2020 16 12 2020 16 12 2020 4 Suppl 1 Program Abstracts from The GSA 2020 Annual Scientific Meeting “Turning 75: Why Age Matters”663 664 © The Author(s) 2020. Published by Oxford University Press on behalf of The Gerontological Society of America.2020This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.Abstract Detecting functional decline is critical in recognizing clinical progression into mild cognitive impairment and dementia as people age. This study aimed to investigate differences in Instrumental Activities of Daily Living (IADL) and associations with cognition by gender. Data are from five waves of TILDA, a nationally representative cohort of 8,175 aged ≥50 years, measured every 2 years between 2009 and 2018. IADL assessed were preparing a hot meal, doing household chores, shopping for groceries, making telephone calls, taking medications, and managing money. Cognition was assessed using the Mini-Mental-State Examination (MMSE). Latent class analysis and growth mixture modelling techniques were used to identify IADL and cognitive latent classes and examine change trajectories. IADL trajectories differed by gender and were associated with cognitive decline. Functional decline discrepancies between men and women may be driven by domestic tasks within IADL which are associated with social gender roles, rather than determining differential cognitive trajectories.