==== Front Innov Aging Innov Aging innovateage Innovation in Aging 2399-5300 Oxford University Press US 10.1093/geroni/igaa057.2821 igaa057.2821 Abstracts Session 7155 (Symposium) AcademicSubjects/SOC02600 Cognitive Reserve and Well-Being Among Centenarians Martin Peter 1 Lee Gina 1 Gondo Yasuyuki 2 Poon Leonard 3 1 Iowa State University, Ames, Iowa, United States 2 Osaka University, Suita, Osaka, Japan 3 University of Georgia, Athens, Georgia, United States 2020 16 12 2020 16 12 2020 4 Suppl 1 Program Abstracts from The GSA 2020 Annual Scientific Meeting “Turning 75: Why Age Matters”780 780 © The Author(s) 2020. Published by Oxford University Press on behalf of The Gerontological Society of America.2020This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.Abstract The purpose of this study was to assess cognitive reserve among centenarians and to evaluate whether reserve variables explain significantly more variance in cognitive functioning than education alone. Centenarians from the Georgia Centenarians Study were included. Results indicate that education, activity, social engagement, and engaged lifestyle significantly related to cognitive functioning. After adding cognitive reserve variables, the effect of education on cognitive functioning diminished. The overall model fit well, Χ2 (df=6) = 12.35, p = .06; CFI = .97, RMSEA = .067. Education indirectly related to cognitive functioning through occupational responsibility and engaged lifestyle. Social engagement directly related to cognitive functioning but also indirectly through activity levels. The four direct predictors (i.e., education, social engagement, activity, and engaged lifestyle) explained 33 percent of the variance in cognitive functioning. The results provide important information for cognitive reserve theories with implications for physical health and interventions that build cognitive reserves.