==== Front Innov Aging Innov Aging innovateage Innovation in Aging 2399-5300 Oxford University Press US 10.1093/geroni/igaa057.3008 igaa057.3008 Abstracts Session 7565 (Symposium) AcademicSubjects/SOC02600 Self-Perception of Aging and Frailty Phenotype Among HIV+ and HIV- Older Men Plankey Michael 1 Nieves-Lugo Karen 2 Ware Deanna 1 Haberlen Sabina 3 Althoff Keri 3 Egan James 4 Brown Andre 4 Friedman Mackey 4 1 Georgetown University Medical Center, Washington, District of Columbia, United States 2 National Institutes of Health, Bethesda, Maryland, United States 3 Johns Hopkins University, Baltimore, Maryland, United States 4 University of Pittsburgh, Pittsburgh, Pennsylvania, United States 2020 16 12 2020 16 12 2020 4 Suppl 1 Program Abstracts from The GSA 2020 Annual Scientific Meeting “Turning 75: Why Age Matters”824 824 © The Author(s) 2020. Published by Oxford University Press on behalf of The Gerontological Society of America.2020This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.Abstract Self-perception of aging is an important predictor of health. We examined the relationship of self-perception of aging (age discrepancy and aging satisfaction) with frailty phenotype between HIV+ and HIV- men in the Multicenter AIDS Cohort Study. 499 HIV+ and 549 HIV- men were included in the analytic sample (median age 61 years IQR 56-66 years). Frailty status was based on the Fried frailty phenotype and measured at semi-annual study visits beginning 3/2015 or 9/2015, 3/2016 and 3/2019. Baseline frailty was: HIV- 8.9%; HIV+ 13.9%. Low aging satisfaction and feeling older was positively associated with remaining frail (ORs: 6.64;95%CI:3.88-11.38; 5.68; 95%CI:3.06-10.56) or transitioning between non-frail and frail states (ORs: 2.72;95%CI:1.56-4.74; 2.50; 95%CI:1.11-5.64),), over a 3-year period. There was no statistically significant difference by HIV status. Assessment of self-perception of aging may be useful in the setting of frailty evaluation among HIV+ and HIV- men.