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Innov Aging
Innov Aging
innovateage
Innovation in Aging
2399-5300 Oxford University Press US 

10.1093/geroni/igaa057.3152
igaa057.3152
Abstracts
Session 7710 (Symposium)
AcademicSubjects/SOC02600
REGARDS Cognitive Assessment and Approaches to Defining Cognitive Impairment and Change in Cognitive Function
Manly Jennifer 1 Unverzagt Frederick 2 McClure Leslie 3 Judd Suzanne 4 Rhodes J David 4 Howard George 4 1 
Columbia University, New York, New York, United States
2 
Indiana University School of Medicine, Indianapolis, Indiana, United States
3 
Drexel University, Philadelphia, Pennsylvania, United States
4 
University of Alabama at Birmingham, Birmingham, Alabama, United States
2020 
16 12 2020 
16 12 2020 
4 Suppl 1 Program Abstracts from The GSA 2020 Annual Scientific Meeting “Turning 75: Why Age Matters”856 856
© The Author(s) 2020. Published by Oxford University Press on behalf of The Gerontological Society of America.2020This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.Abstract
Since 2003, REGARDS participants have taken part in telephone-based cognitive assessments. Global cognitive status is assessed annually with the Six-item Screener. Between 2006 and 2009, measures of learning and memory (CERAD Word List) and language/executive function (Animal and Letter Fluency) were implemented, and are administered biennially. A Brain Health Substudy, conducting in-home clinical examinations of neuropsychological, neurological, and functional status among 1000 participants, is underway to validate telephone assessments and estimate prevalence of VCID in REGARDS. Approaches to defining incident cognitive impairment and cognitive change, including definitions employed for case/cohort studies using stored blood samples, will be described. We will discuss psychometric and methodological considerations for characterization of risks for cognitive impairment across race and region, as well as longitudinal trajectories of cognitive function.