==== Front
Innov Aging
Innov Aging
innovateage
Innovation in Aging
2399-5300 Oxford University Press US 

10.1093/geroni/igaa057.864
igaa057.864
Abstracts
Session 2925 (Paper)
Frailty
AcademicSubjects/SOC02600
Frailty Component Trajectories After Restoration of Kidney Function Among Kidney Transplant Recipients
Chu Nadia 1 Chen Xiaomeng 1 Segev Dorry 1 McAdams-DeMarco Mara 2 1 
Johns Hopkins School of Medicine, Baltimore, Maryland, United States
2 
Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States
2020 
16 12 2020 
16 12 2020 
4 Suppl 1 Program Abstracts from The GSA 2020 Annual Scientific Meeting “Turning 75: Why Age Matters”270 270
© The Author(s) 2020. Published by Oxford University Press on behalf of The Gerontological Society of America.2020This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.Abstract
Frailty is associated with decreased access to kidney transplantation (KT) and poor post-KT outcomes. Little is known about how an acute stressor, like KT, can impact the five physical frailty phenotype (PFP) criteria. We conducted a two-center prospective cohort study (2009-2019) of adult patients undergoing KT. PFP criteria were measured at KT admission, 1 month, 3 months, 6 months, 1 year, and annually thereafter post-KT. We used adjusted mixed effects models with fixed and random effects for person and time to describe repeated measures of continuous criteria components (weight, gait speed, grip strength, activity). We used an adjusted generalized estimating equation to quantify longitudinal, binomial response patterns of exhaustion. Among 1,410 KT recipients (mean age=53) followed for a mean of 1.9 years (IQR=0.1-3.2), 46.8% had low activity, 46.7% weakness, 29.0% exhaustion, 16.1% slowness, and 14.3% unintentional weight loss at KT admission. Among continuous components, weight worsened (0.3lb/month, 95%CI:0.2,0.4), while grip strength (0.09kg/month, 95%CI: 0.07,0.11) and activity (5.8Kcal/month, 95%CI: 3.3, 8.2) improved post-KT; gait speed remained stable (-0.0004s/month, 95%CI: -0.01, 0.0005). Additionally, likelihood of transitioning from being exhausted did not change (OR=1.0, 95%CI: -0.01, 0.0005). Trajectories differed by age, such that improvements were observed among younger recipients (<65 years), but not among older recipients (≥65 years) (p-interactions<0.05). After undergoing a common surgical stressor, KT recipients demonstrated weight gain as well as improvements in strength and activity. Despite benefits of restoration of kidney function, clinicians should consider monitoring KT recipients for persistent weight gain, exhaustion, and slowness post-KT, particularly among older adults.