==== Front Innov Aging Innov Aging innovateage Innovation in Aging 2399-5300 Oxford University Press US 10.1093/geroni/igaa057.1127 igaa057.1127 Abstracts Session 2944 (Poster) Caregiving I (BSS) AcademicSubjects/SOC02600 Caregiver Depression, Change in the Severity of Neuropsychiatric Symptoms, and Subsequent Caregiver Abuse Fang Boye 1 Yan Elsie 2 Pei Yaolin 3 Chen Gengzhen 4 1 Sun Yat-Sen University, Guangzhou, China 2 The Hong Kong Polytechnic University, Hong Kong, China 3 New York University, New York, New York, United States 4 Shantou University Medical College, Shantou, China 2020 16 12 2020 16 12 2020 4 Suppl 1 Program Abstracts from The GSA 2020 Annual Scientific Meeting “Turning 75: Why Age Matters”350 351 © The Author(s) 2020. Published by Oxford University Press on behalf of The Gerontological Society of America.2020This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.Abstract Objectives: To examine whether caregiver (CG) depression predicts subsequent occurrence of elder abuse and whether change in the severity how care-recipient change in the severity of care recipient (CR) neuropsychiatric symptoms influence this association. Methods: Using two-year longitudinal data, we analyzed a consecutive sample of 800 Chinese family CGs and their CRs with dementia recruited from the geriatric and neurological departments of three Grade-A hospitals in People’s Republic of China (PRC). All the participatory dyads were assessed between September 2015 and February 2016 and followed for two years. Results: CG depression at baseline predicted the subsequent occurrence of physical and psychological abuse and CG neglect. However, change in the severity of CR neuropsychiatric symptoms altered these relationships. Specifically, while unchanged and increased CR neuropsychiatric symptoms heightened the positive effect of CG depression on subsequent abuse, decreased CR neuropsychiatric symptoms protected older adults from abuse by a depressed CG. Conclusion: This study showed the differential impact of CG depression on subsequent occurrence of elder abuse depending on the change in the severity of neuropsychiatric symptoms related to the CRs. The present findings provide important insights to the design of a systematic and integrative intervention protocol for elder abuse that simultaneously focuses on treating CG depression and CR neuropsychiatric symptoms.