==== Front Innov Aging Innov Aging innovateage Innovation in Aging 2399-5300 Oxford University Press US 10.1093/geroni/igaa057.826 igaa057.826 Abstracts Session 2917 (Paper) Chronic Disease and Multimorbidity II AcademicSubjects/SOC02600 Dual-Task Gait Cost and Frontal Lobe Integrity in Poststroke: Results From ONDRI Pieruccini-Faria Frederico 1 McLaughlin Paula 2 Cornish Benjamin 3 Binns Malcolm 4 Bartha Robert 5 McIlroy Bill 3 ONDRI Collaborators 6 Odasso Manuel Montero 7 Faria Frederico 1 1 University of Western Ontario, London, Ontario, Canada 2 Queens University, Kingston, Ontario, Canada 3 University of Waterloo, Waterloo, Ontario, Canada 4 Baycrest Health Sciences, Toronto, Ontario, Canada 5 Robarts-Western University, London, Ontario, Canada 6 Ontario Brain Institute, Toronto, Ontario, Canada 7 The University of Western Ontario, London, Ontario, Canada 2020 16 12 2020 16 12 2020 4 Suppl 1 Program Abstracts from The GSA 2020 Annual Scientific Meeting “Turning 75: Why Age Matters”257 257 © The Author(s) 2020. Published by Oxford University Press on behalf of The Gerontological Society of America.2020This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.Abstract Dual-task gait performance is a marker of motor-cognitive interactions modulated by the frontal lobes. After a stroke, gait disturbances are more evident, particularly when concurrently completing a mental task and walking, an effect called high dual-task cost (DTC). Following a stroke, the potential association of high-DTC, integrity of the frontal lobes and cognitive functioning is unclear. This study screened 161 participants with stroke history from the Ontario Neurodegenerative Disease Research Initiative (ONDRI)-cerebrovascular disease cohort (69.2±7.41 years of age; 31.7% women). Individuals scoring zero in the National Institute of Health Stroke Scale were analyzed (n=102). DTC was the percentage change in gait speed from the single to dual-task condition. Standardized normal-appearing white matter (NAWM) and grey matter (NAGM) volumes from superior, middle and inferior frontal lobe were compared between DTC quartiles (adjusted for age, sex, and education) using a multivariate model (MANOVA), with total frontal lobe volume as a covariate. Another model compared group performance across 5 adjusted cognitive domains (attention, memory, language, visuospatial performance, and executive functioning). Univariate tests revealed that NAWM volume in the superior frontal lobe (F=4.50; p=0.005; partial eta-squared=0.122) was significantly different across DTC quartiles. Contrast tests suggested that the first quartile had larger NAWM than the second and fourth. DTC quartiles also showed differences in attention (F=2.93; p=0.03; partial eta-squared=0.083) and contrast tests indicated that the first quartile performed significantly better than second and fourth. DTC poststroke may be a proxy for structural integrity of superior frontal lobe regions and attention.