==== Front Innov Aging Innov Aging innovateage Innovation in Aging 2399-5300 Oxford University Press US 10.1093/geroni/igaa057.381 igaa057.381 Abstracts Session 2872 (Poster) Services and Intervention: Experiences and Outcomes AcademicSubjects/SOC02600 Age and Sex Differences of Comorbidities in Medicare Older Adults With Chronic Obstructive Pulmonary Disease Le Tham Simoni-Wastila Linda University of Maryland, Baltimore, Maryland, United States 2020 16 12 2020 16 12 2020 4 Suppl 1 Program Abstracts from The GSA 2020 Annual Scientific Meeting “Turning 75: Why Age Matters”115 116 © The Author(s) 2020. Published by Oxford University Press on behalf of The Gerontological Society of America.2020This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.Abstract OBJECTIVES: Although comorbidity varies by sex and age, comorbidity variation among individuals with specific primary conditions is less well-understood. We sought to quantify chronic comorbidities in older adults with chronic obstructive pulmonary disease (COPD) using representative Medicare claims data. METHODS: This retrospective cohort study consisted of individuals aged 65+ with a COPD diagnosis identified in a 5% Medicare sample enrolled between 1/1/2012-1/1/2015. We quantified the prevalence of 40 comorbidities and sex and age variation (≥ or ≤ 85 years). RESULTS: Of 461,268 eligible beneficiaries, 60% were female, 86% were white, with mean (SD) age of 79 (8) years. The majority (89.2%) had at least 5 comorbidities; 50.4% had ≥ ten comorbidities. Most prevalent conditions included: hypertension (92.6%), hyperlipidemia (86.4%), anemia (74.9%), rheumatoid arthritis (RA) (68.0%), congestive heart failure (CHF) (49.6%), diabetes (46.7%), depression (43.7%), peripheral vascular disease (PVD) (42.9%), and chronic kidney disease (CKD) (38.6.) Male patients had higher prevalence of CHF, diabetes, CKD, atrial fibrillation (AFib), AMI, cancer, tobacco use disorder, and liver disease, while females had higher prevalence of hypertension, anemia, RA, depression, asthma, osteoporosis, pain, hypothyroid, obesity, dementia, and glaucoma. Compared to patients under 85, those aged ≥85 years had higher prevalence of cardiovascular disease, depression, musculoskeletal conditions, cancer, dementia, glaucoma, and CKD; but lower prevalence of asthma, anxiety, and metabolic disorders. CONCLUSIONS: Older adults with COPD encounter a high prevalence of comorbidities. Comorbidity patterns differs across age and sex spectrum, highlighting the significance of age and sex in developing individualized clinical care and epidemiological research.