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Innov Aging
Innov Aging
innovateage
Innovation in Aging
2399-5300 Oxford University Press US 

10.1093/geroni/igaa057.2204
igaa057.2204
Abstracts
Session 5850 (Symposium)
AcademicSubjects/SOC02600
Interplay Between Socioeconomic Markers and Genetic Predisposition to the Time to Dementia Onset
Ajnakina Olesya  Cadar Dorina  Steptoe Andrew  
University College London, London, England, United Kingdom
2020 
16 12 2020 
16 12 2020 
4 Suppl 1 Program Abstracts from The GSA 2020 Annual Scientific Meeting “Turning 75: Why Age Matters”642 642
© The Author(s) 2020. Published by Oxford University Press on behalf of The Gerontological Society of America.2020This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.Abstract
Identifying interplay between socio-economic markers (education and financial resources) and genetic factors influencing time of dementia and Alzheimer’s disease (AD) diagnosis is of central relevance for the development of preventative strategies. Using 7039 individuals aged >50 years from the English Longitudinal Study of Ageing, 320 (4.6%) of whom developed dementia over the 10-year follow-up, we investigated interactions between polygenic score for AD (AD-PGS) and socioeconomic markers on the timing of dementia or AD diagnosis. One standard deviation increase in AD-PGS was associated with an accelerated time to dementia onset by 4.8 months. Interactions between AD-PGS and lower wealth accelerated time to AD diagnosis by 24 months; an interaction between AD-PGS and years of schooling in decelerating time to AD by 3.0 months suggests education serves as protective mechanisms against AD diagnosis. Socio-economic markers are important factors influencing time to dementia and AD, particularly in those with polygenetic predisposition to AD.