LOCUS       NP_001106659             677 aa            linear   ROD 07-OCT-2023
DEFINITION  RNA-binding protein FXR1 isoform 1 [Mus musculus].
ACCESSION   NP_001106659
VERSION     NP_001106659.1
DBSOURCE    REFSEQ: accession NM_001113188.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 677)
  AUTHORS   Zhou GF, Tang J, Ma YL, Fu X, Liu JY, Yang RZ, Zhang HS, Cai XH,
            Wang JW, Xie XY, Song L, Luo B, Chen J, Chen L, Deng XJ and Chen
            GJ.
  TITLE     ARL6IP1 mediates small-molecule-induced alleviation of Alzheimer
            pathology through FXR1-dependent BACE1 translation initiation
  JOURNAL   Proc Natl Acad Sci U S A 120 (22), e2220148120 (2023)
   PUBMED   37216506
  REMARK    GeneRIF: ARL6IP1 mediates small-molecule-induced alleviation of
            Alzheimer pathology through FXR1-dependent BACE1 translation
            initiation.
REFERENCE   2  (residues 1 to 677)
  AUTHORS   Corbett CB, St Paul A, Leigh T, Kelemen SE, Peluzzo AM, Okune RN,
            Eguchi S, Haines DS and Autieri MV.
  TITLE     Genetic Deletion of FXR1 Reduces Intimal Hyperplasia and Induces
            Senescence in Vascular Smooth Muscle Cells
  JOURNAL   Am J Pathol 193 (5), 638-653 (2023)
   PUBMED   37080662
  REMARK    GeneRIF: Genetic Deletion of FXR1 Reduces Intimal Hyperplasia and
            Induces Senescence in Vascular Smooth Muscle Cells.
REFERENCE   3  (residues 1 to 677)
  AUTHORS   St Paul A, Corbett C, Peluzzo A, Kelemen S, Okune R, Haines DS,
            Preston K, Eguchi S and Autieri MV.
  TITLE     FXR1 regulates vascular smooth muscle cell cytoskeleton, VSMC
            contractility, and blood pressure by multiple mechanisms
  JOURNAL   Cell Rep 42 (4), 112381 (2023)
   PUBMED   37043351
REFERENCE   4  (residues 1 to 677)
  AUTHORS   Kang JY, Wen Z, Pan D, Zhang Y, Li Q, Zhong A, Yu X, Wu YC, Chen Y,
            Zhang X, Kou PC, Geng J, Wang YY, Hua MM, Zong R, Li B, Shi HJ, Li
            D, Fu XD, Li J, Nelson DL, Guo X, Zhou Y, Gou LT, Huang Y and Liu
            MF.
  TITLE     LLPS of FXR1 drives spermiogenesis by activating translation of
            stored mRNAs
  JOURNAL   Science 377 (6607), eabj6647 (2022)
   PUBMED   35951695
  REMARK    GeneRIF: LLPS of FXR1 drives spermiogenesis by activating
            translation of stored mRNAs.
REFERENCE   5  (residues 1 to 677)
  AUTHORS   Khamoui AV, Tokmina-Roszyk D, Feresin RG, Fields GB and Visavadiya
            NP.
  TITLE     Skeletal muscle proteome expression differentiates severity of
            cancer cachexia in mice and identifies loss of fragile X mental
            retardation syndrome-related protein 1
  JOURNAL   Proteomics 22 (10), e2100157 (2022)
   PUBMED   35289490
  REMARK    GeneRIF: Skeletal muscle proteome expression differentiates
            severity of cancer cachexia in mice and identifies loss of fragile
            X mental retardation syndrome-related protein 1.
REFERENCE   6  (residues 1 to 677)
  AUTHORS   Schenck A, Bardoni B, Moro A, Bagni C and Mandel JL.
  TITLE     A highly conserved protein family interacting with the fragile X
            mental retardation protein (FMRP) and displaying selective
            interactions with FMRP-related proteins FXR1P and FXR2P
  JOURNAL   Proc Natl Acad Sci U S A 98 (15), 8844-8849 (2001)
   PUBMED   11438699
REFERENCE   7  (residues 1 to 677)
  AUTHORS   Dube M, Huot ME and Khandjian EW.
  TITLE     Muscle specific fragile X related protein 1 isoforms are
            sequestered in the nucleus of undifferentiated myoblast
  JOURNAL   BMC Genet 1, 4 (2000)
   PUBMED   11178106
  REMARK    GeneRIF: Four FXR1 isoforms of molecular weight 70, 74, 78, 80 kDa
            are widely distributed in mouse organs, while in striated muscles
            these isoforms are replaced by proteins of 82 and 84 kDa containing
            an extra pocket of 27 amino acids.
REFERENCE   8  (residues 1 to 677)
  AUTHORS   Ceman S, Brown V and Warren ST.
  TITLE     Isolation of an FMRP-associated messenger ribonucleoprotein
            particle and identification of nucleolin and the fragile X-related
            proteins as components of the complex
  JOURNAL   Mol Cell Biol 19 (12), 7925-7932 (1999)
   PUBMED   10567518
REFERENCE   9  (residues 1 to 677)
  AUTHORS   Kirkpatrick LL, McIlwain KA and Nelson DL.
  TITLE     Alternative splicing in the murine and human FXR1 genes
  JOURNAL   Genomics 59 (2), 193-202 (1999)
   PUBMED   10409431
REFERENCE   10 (residues 1 to 677)
  AUTHORS   Coy JF, Sedlacek Z, Bachner D, Hameister H, Joos S, Lichter P,
            Delius H and Poustka A.
  TITLE     Highly conserved 3' UTR and expression pattern of FXR1 points to a
            divergent gene regulation of FXR1 and FMR1
  JOURNAL   Hum Mol Genet 4 (12), 2209-2218 (1995)
   PUBMED   8634689
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115078.11 and AC068294.26.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1, also known as
            isoform e).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.17386.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..677
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 16.41 cM"
     Protein         1..677
                     /product="RNA-binding protein FXR1 isoform 1"
                     /note="RNA-binding protein FXR1"
                     /calculated_mol_wt=76091
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:P51114; propagated from
                     UniProtKB/Swiss-Prot (Q61584.2)"
     Region          3..57
                     /region_name="Tudor_Agenet_FXR1_rpt1"
                     /note="first Tudor-like Agenet domain found in fragile X
                     mental retardation syndrome-related protein 1 (FXR1) and
                     similar proteins; cd20472"
                     /db_xref="CDD:410543"
     Site            order(10,14,16,32,36,38)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410543"
     Region          61..126
                     /region_name="Tudor_Agenet_FXR1_rpt2"
                     /note="second Tudor-like Agenet domain found in fragile X
                     mental retardation syndrome-related protein 1 (FXR1) and
                     similar proteins; cd20475"
                     /db_xref="CDD:410546"
     Site            68
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0007744|PubMed:17947660; propagated from
                     UniProtKB/Swiss-Prot (Q61584.2)"
     Site            order(69,78,80,96,101,103)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410546"
     Region          123..199
                     /region_name="KH_I_FXR1_rpt1"
                     /note="first type I K homology (KH) RNA-binding domain
                     found in fragile X mental retardation syndrome-related
                     protein 1 (FXR1) and similar proteins; cd22504"
                     /db_xref="CDD:411932"
     Region          218..280
                     /region_name="KH_I_FXR1_rpt2"
                     /note="second type I K homology (KH) RNA-binding domain
                     found in fragile X mental retardation syndrome-related
                     protein 1 (FXR1) and similar proteins; cd22507"
                     /db_xref="CDD:411935"
     Site            order(228,230..232,234..238,241..242,245..246,252..255)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:411935"
     Region          281..358
                     /region_name="KH_I_FXR1_rpt3"
                     /note="third type I K homology (KH) RNA-binding domain
                     found in fragile X mental retardation syndrome-related
                     protein 1 (FXR1) and similar proteins; cd22510"
                     /db_xref="CDD:411938"
     Site            order(291,293..295,297..301,304..305,308..309,315..318)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:411938"
     Region          354..467
                     /region_name="FXMRP1_C_core"
                     /note="Fragile X-related 1 protein core C terminal;
                     pfam12235"
                     /db_xref="CDD:432414"
     Region          380..677
                     /region_name="Disordered.
                     /evidence=ECO:0000269|PubMed:35951695"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61584.2)"
     Site            398
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q5XI81; propagated from
                     UniProtKB/Swiss-Prot (Q61584.2)"
     Site            430
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P51114; propagated from
                     UniProtKB/Swiss-Prot (Q61584.2)"
     Site            432
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q5XI81; propagated from
                     UniProtKB/Swiss-Prot (Q61584.2)"
     Site            435
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61584.2)"
     Site            438
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61584.2)"
     Site            449
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355; propagated from
                     UniProtKB/Swiss-Prot (Q61584.2)"
     Site            452
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P51114; propagated from
                     UniProtKB/Swiss-Prot (Q61584.2)"
     Region          471..486
                     /region_name="RNA-binding RGG-box"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61584.2)"
     Site            476
                     /site_type="methylation"
                     /note="Asymmetric dimethylarginine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P35922;
                     Omega-N-methylarginine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P35922; propagated from
                     UniProtKB/Swiss-Prot (Q61584.2)"
     Site            482
                     /site_type="methylation"
                     /note="Asymmetric dimethylarginine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P35922;
                     Omega-N-methylarginine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P35922; propagated from
                     UniProtKB/Swiss-Prot (Q61584.2)"
     Site            484
                     /site_type="methylation"
                     /note="Asymmetric dimethylarginine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P35922;
                     Omega-N-methylarginine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P35922; propagated from
                     UniProtKB/Swiss-Prot (Q61584.2)"
     Region          491..564
                     /region_name="FXR_C1"
                     /note="Fragile X-related 1 protein C-terminal region 2;
                     pfam16096"
                     /db_xref="CDD:435133"
     Site            512
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61584.2)"
     Site            514
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P51114; propagated from
                     UniProtKB/Swiss-Prot (Q61584.2)"
     Site            553
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P51116; propagated from
                     UniProtKB/Swiss-Prot (Q61584.2)"
     Region          610..676
                     /region_name="FXR_C3"
                     /note="Fragile X-related 1 protein C-terminal region 3;
                     pfam16097"
                     /db_xref="CDD:435134"
     Site            643
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61584.2)"
     Site            667
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P51114; propagated from
                     UniProtKB/Swiss-Prot (Q61584.2)"
     CDS             1..677
                     /gene="Fxr1"
                     /gene_synonym="1110050J02Rik; 9530073J07Rik; Fxr1h; Fxr1p"
                     /coded_by="NM_001113188.2:16..2049"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS50891.1"
                     /db_xref="GeneID:14359"
                     /db_xref="MGI:MGI:104860"
ORIGIN      
        1 maeltvevrg sngafykgfi kdvhedsltv vfennwqper qvpfnevrlp pppdikkeis
       61 egdevevysr andqepcgww lakvrmmkge fyvieyaacd atyneivtfe rlrpvnqnkt
      121 vkkntffkct vdvpedlrea canenahkdf kkavgacrif yhpettqlmi lsaseatvkr
      181 vnilsdmhlr sirtklmlms rneeatkhle ctkqlaaafh eefvvredlm glaigthgsn
      241 iqqarkvpgv taieldedtg tfriygesae avkkargfle fvedfiqvpr nlvgkvigkn
      301 gkviqeivdk sgvvrvrieg dnenklpred gmvpfvfvgt kesignvqvl leyhiaylke
      361 veqlrmerlq ideqlrqigm gfrpsstrgp erekgyatde stvssvqgsr sysgrgrgrr
      421 gpnytsgygt nselsnpset eserkdelsd wslageddre trhqrdsrrr pggrgrsvsg
      481 grgrggprgg kssissvlkd pdsnpyslld ntesdqtadt daseshhstn rrrrsrrrrt
      541 dedavlmdgl tesdtasvne nglddsekkp qrrnrsrrrr frgqaedrqp vtvadyisra
      601 esqsrqrnlp retlaknkke makdvieehg psekaingpt sasgdeipkl prtlgeektk
      661 tlkedstqea avlngvs
//
LOCUS       NP_001106660             621 aa            linear   ROD 07-OCT-2023
DEFINITION  RNA-binding protein FXR1 isoform 2 [Mus musculus].
ACCESSION   NP_001106660
VERSION     NP_001106660.1
DBSOURCE    REFSEQ: accession NM_001113189.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 621)
  AUTHORS   Zhou GF, Tang J, Ma YL, Fu X, Liu JY, Yang RZ, Zhang HS, Cai XH,
            Wang JW, Xie XY, Song L, Luo B, Chen J, Chen L, Deng XJ and Chen
            GJ.
  TITLE     ARL6IP1 mediates small-molecule-induced alleviation of Alzheimer
            pathology through FXR1-dependent BACE1 translation initiation
  JOURNAL   Proc Natl Acad Sci U S A 120 (22), e2220148120 (2023)
   PUBMED   37216506
  REMARK    GeneRIF: ARL6IP1 mediates small-molecule-induced alleviation of
            Alzheimer pathology through FXR1-dependent BACE1 translation
            initiation.
REFERENCE   2  (residues 1 to 621)
  AUTHORS   Corbett CB, St Paul A, Leigh T, Kelemen SE, Peluzzo AM, Okune RN,
            Eguchi S, Haines DS and Autieri MV.
  TITLE     Genetic Deletion of FXR1 Reduces Intimal Hyperplasia and Induces
            Senescence in Vascular Smooth Muscle Cells
  JOURNAL   Am J Pathol 193 (5), 638-653 (2023)
   PUBMED   37080662
  REMARK    GeneRIF: Genetic Deletion of FXR1 Reduces Intimal Hyperplasia and
            Induces Senescence in Vascular Smooth Muscle Cells.
REFERENCE   3  (residues 1 to 621)
  AUTHORS   St Paul A, Corbett C, Peluzzo A, Kelemen S, Okune R, Haines DS,
            Preston K, Eguchi S and Autieri MV.
  TITLE     FXR1 regulates vascular smooth muscle cell cytoskeleton, VSMC
            contractility, and blood pressure by multiple mechanisms
  JOURNAL   Cell Rep 42 (4), 112381 (2023)
   PUBMED   37043351
REFERENCE   4  (residues 1 to 621)
  AUTHORS   Kang JY, Wen Z, Pan D, Zhang Y, Li Q, Zhong A, Yu X, Wu YC, Chen Y,
            Zhang X, Kou PC, Geng J, Wang YY, Hua MM, Zong R, Li B, Shi HJ, Li
            D, Fu XD, Li J, Nelson DL, Guo X, Zhou Y, Gou LT, Huang Y and Liu
            MF.
  TITLE     LLPS of FXR1 drives spermiogenesis by activating translation of
            stored mRNAs
  JOURNAL   Science 377 (6607), eabj6647 (2022)
   PUBMED   35951695
  REMARK    GeneRIF: LLPS of FXR1 drives spermiogenesis by activating
            translation of stored mRNAs.
REFERENCE   5  (residues 1 to 621)
  AUTHORS   Khamoui AV, Tokmina-Roszyk D, Feresin RG, Fields GB and Visavadiya
            NP.
  TITLE     Skeletal muscle proteome expression differentiates severity of
            cancer cachexia in mice and identifies loss of fragile X mental
            retardation syndrome-related protein 1
  JOURNAL   Proteomics 22 (10), e2100157 (2022)
   PUBMED   35289490
  REMARK    GeneRIF: Skeletal muscle proteome expression differentiates
            severity of cancer cachexia in mice and identifies loss of fragile
            X mental retardation syndrome-related protein 1.
REFERENCE   6  (residues 1 to 621)
  AUTHORS   Schenck A, Bardoni B, Moro A, Bagni C and Mandel JL.
  TITLE     A highly conserved protein family interacting with the fragile X
            mental retardation protein (FMRP) and displaying selective
            interactions with FMRP-related proteins FXR1P and FXR2P
  JOURNAL   Proc Natl Acad Sci U S A 98 (15), 8844-8849 (2001)
   PUBMED   11438699
REFERENCE   7  (residues 1 to 621)
  AUTHORS   Dube M, Huot ME and Khandjian EW.
  TITLE     Muscle specific fragile X related protein 1 isoforms are
            sequestered in the nucleus of undifferentiated myoblast
  JOURNAL   BMC Genet 1, 4 (2000)
   PUBMED   11178106
  REMARK    GeneRIF: Four FXR1 isoforms of molecular weight 70, 74, 78, 80 kDa
            are widely distributed in mouse organs, while in striated muscles
            these isoforms are replaced by proteins of 82 and 84 kDa containing
            an extra pocket of 27 amino acids.
REFERENCE   8  (residues 1 to 621)
  AUTHORS   Ceman S, Brown V and Warren ST.
  TITLE     Isolation of an FMRP-associated messenger ribonucleoprotein
            particle and identification of nucleolin and the fragile X-related
            proteins as components of the complex
  JOURNAL   Mol Cell Biol 19 (12), 7925-7932 (1999)
   PUBMED   10567518
REFERENCE   9  (residues 1 to 621)
  AUTHORS   Kirkpatrick LL, McIlwain KA and Nelson DL.
  TITLE     Alternative splicing in the murine and human FXR1 genes
  JOURNAL   Genomics 59 (2), 193-202 (1999)
   PUBMED   10409431
REFERENCE   10 (residues 1 to 621)
  AUTHORS   Coy JF, Sedlacek Z, Bachner D, Hameister H, Joos S, Lichter P,
            Delius H and Poustka A.
  TITLE     Highly conserved 3' UTR and expression pattern of FXR1 points to a
            divergent gene regulation of FXR1 and FMR1
  JOURNAL   Hum Mol Genet 4 (12), 2209-2218 (1995)
   PUBMED   8634689
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115078.11 and AC068294.26.
            
            Transcript Variant: This variant (2) lacks alternate in-frame
            segments in both the mid-coding and 3' coding regions, compared to
            variant 1, resulting in a shorter protein (isoform 2, also known as
            isoform d), compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422600.560329.1,
                                           SRR13422590.40118.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..621
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 16.41 cM"
     Protein         1..621
                     /product="RNA-binding protein FXR1 isoform 2"
                     /note="RNA-binding protein FXR1"
                     /calculated_mol_wt=69584
     Region          3..57
                     /region_name="Tudor_Agenet_FXR1_rpt1"
                     /note="first Tudor-like Agenet domain found in fragile X
                     mental retardation syndrome-related protein 1 (FXR1) and
                     similar proteins; cd20472"
                     /db_xref="CDD:410543"
     Site            order(10,14,16,32,36,38)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410543"
     Region          61..126
                     /region_name="Tudor_Agenet_FXR1_rpt2"
                     /note="second Tudor-like Agenet domain found in fragile X
                     mental retardation syndrome-related protein 1 (FXR1) and
                     similar proteins; cd20475"
                     /db_xref="CDD:410546"
     Site            order(69,78,80,96,101,103)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410546"
     Region          123..199
                     /region_name="KH_I_FXR1_rpt1"
                     /note="first type I K homology (KH) RNA-binding domain
                     found in fragile X mental retardation syndrome-related
                     protein 1 (FXR1) and similar proteins; cd22504"
                     /db_xref="CDD:411932"
     Region          218..280
                     /region_name="KH_I_FXR1_rpt2"
                     /note="second type I K homology (KH) RNA-binding domain
                     found in fragile X mental retardation syndrome-related
                     protein 1 (FXR1) and similar proteins; cd22507"
                     /db_xref="CDD:411935"
     Site            order(228,230..232,234..238,241..242,245..246,252..255)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:411935"
     Region          281..358
                     /region_name="KH_I_FXR1_rpt3"
                     /note="third type I K homology (KH) RNA-binding domain
                     found in fragile X mental retardation syndrome-related
                     protein 1 (FXR1) and similar proteins; cd22510"
                     /db_xref="CDD:411938"
     Site            order(291,293..295,297..301,304..305,308..309,315..318)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:411938"
     Region          354..438
                     /region_name="FXMRP1_C_core"
                     /note="Fragile X-related 1 protein core C terminal;
                     pfam12235"
                     /db_xref="CDD:432414"
     Region          462..535
                     /region_name="FXR_C1"
                     /note="Fragile X-related 1 protein C-terminal region 2;
                     pfam16096"
                     /db_xref="CDD:435133"
     Region          554..620
                     /region_name="FXR_C3"
                     /note="Fragile X-related 1 protein C-terminal region 3;
                     pfam16097"
                     /db_xref="CDD:435134"
     CDS             1..621
                     /gene="Fxr1"
                     /gene_synonym="1110050J02Rik; 9530073J07Rik; Fxr1h; Fxr1p"
                     /coded_by="NM_001113189.2:16..1881"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS79896.1"
                     /db_xref="GeneID:14359"
                     /db_xref="MGI:MGI:104860"
ORIGIN      
        1 maeltvevrg sngafykgfi kdvhedsltv vfennwqper qvpfnevrlp pppdikkeis
       61 egdevevysr andqepcgww lakvrmmkge fyvieyaacd atyneivtfe rlrpvnqnkt
      121 vkkntffkct vdvpedlrea canenahkdf kkavgacrif yhpettqlmi lsaseatvkr
      181 vnilsdmhlr sirtklmlms rneeatkhle ctkqlaaafh eefvvredlm glaigthgsn
      241 iqqarkvpgv taieldedtg tfriygesae avkkargfle fvedfiqvpr nlvgkvigkn
      301 gkviqeivdk sgvvrvrieg dnenklpred gmvpfvfvgt kesignvqvl leyhiaylke
      361 veqlrmerlq ideqlrqigs rsysgrgrgr rgpnytsgyg tnselsnpse teserkdels
      421 dwslageddr etrhqrdsrr rpggrgrsvs ggrgrggprg gkssissvlk dpdsnpysll
      481 dntesdqtad tdaseshhst nrrrrsrrrr tdedavlmdg ltesdtasvn englvtvady
      541 israesqsrq rnlpretlak nkkemakdvi eehgpsekai ngptsasgde ipklprtlge
      601 ektktlkeds tqeaavlngv s
//
LOCUS       NP_001157553            1197 aa            linear   ROD 07-OCT-2023
DEFINITION  protein timeless homolog isoform 2 [Mus musculus].
ACCESSION   NP_001157553
VERSION     NP_001157553.1
DBSOURCE    REFSEQ: accession NM_001164081.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1197)
  AUTHORS   Barrio-Alonso E, Lituma PJ, Notaras MJ, Albero R, Bouchekioua Y,
            Wayland N, Stankovic IN, Jain T, Gao S, Calderon DP, Castillo PE
            and Colak D.
  TITLE     Circadian protein TIMELESS regulates synaptic function and memory
            by modulating cAMP signaling
  JOURNAL   Cell Rep 42 (4), 112375 (2023)
   PUBMED   37043347
  REMARK    GeneRIF: Circadian protein TIMELESS regulates synaptic function and
            memory by modulating cAMP signaling.
REFERENCE   2  (residues 1 to 1197)
  AUTHORS   Bedogni F and Hevner RF.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1197)
  AUTHORS   Kurien P, Hsu PK, Leon J, Wu D, McMahon T, Shi G, Xu Y, Lipzen A,
            Pennacchio LA, Jones CR, Fu YH and Ptacek LJ.
  TITLE     TIMELESS mutation alters phase responsiveness and causes advanced
            sleep phase
  JOURNAL   Proc Natl Acad Sci U S A 116 (24), 12045-12053 (2019)
   PUBMED   31138685
  REMARK    GeneRIF: The mutation prevents TIM accumulation in the nucleus and
            has altered affinity for CRY2.
REFERENCE   4  (residues 1 to 1197)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1197)
  AUTHORS   Inaguma Y, Ito H, Hara A, Iwamoto I, Matsumoto A, Yamagata T,
            Tabata H and Nagata K.
  TITLE     Morphological characterization of mammalian timeless in the mouse
            brain development
  JOURNAL   Neurosci Res 92, 21-28 (2015)
   PUBMED   25448545
  REMARK    GeneRIF: The obtained results suggest that Tim is expressed in
            neuronal tissues in a spatiotemporally regulated manner and
            involved in developmental stage-specific neuronal functions.
REFERENCE   6  (residues 1 to 1197)
  AUTHORS   Dunlap JC.
  TITLE     Molecular bases for circadian clocks
  JOURNAL   Cell 96 (2), 271-290 (1999)
   PUBMED   9988221
  REMARK    Review article
REFERENCE   7  (residues 1 to 1197)
  AUTHORS   Jin X, Shearman LP, Weaver DR, Zylka MJ, de Vries GJ and Reppert
            SM.
  TITLE     A molecular mechanism regulating rhythmic output from the
            suprachiasmatic circadian clock
  JOURNAL   Cell 96 (1), 57-68 (1999)
   PUBMED   9989497
REFERENCE   8  (residues 1 to 1197)
  AUTHORS   Koike N, Hida A, Numano R, Hirose M, Sakaki Y and Tei H.
  TITLE     Identification of the mammalian homologues of the Drosophila
            timeless gene, Timeless1
  JOURNAL   FEBS Lett 441 (3), 427-431 (1998)
   PUBMED   9891984
REFERENCE   9  (residues 1 to 1197)
  AUTHORS   Zylka MJ, Shearman LP, Levine JD, Jin X, Weaver DR and Reppert SM.
  TITLE     Molecular analysis of mammalian timeless
  JOURNAL   Neuron 21 (5), 1115-1122 (1998)
   PUBMED   9856466
REFERENCE   10 (residues 1 to 1197)
  AUTHORS   Sangoram AM, Saez L, Antoch MP, Gekakis N, Staknis D, Whiteley A,
            Fruechte EM, Vitaterna MH, Shimomura K, King DP, Young MW, Weitz CJ
            and Takahashi JS.
  TITLE     Mammalian circadian autoregulatory loop: a timeless ortholog and
            mPer1 interact and negatively regulate CLOCK-BMAL1-induced
            transcription
  JOURNAL   Neuron 21 (5), 1101-1113 (1998)
   PUBMED   9856465
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC052884.1, BC082770.1 and CJ088470.1.
            
            Summary: The protein encoded by this gene is highly conserved and
            is involved in cell survival after damage or stress, increase in
            DNA polymerase epsilon activity, maintenance of telomere length,
            and epithelial cell morphogenesis. The encoded protein also plays a
            role in the circadian rhythm autoregulatory loop, interacting with
            the PERIOD genes (PER1, PER2, and PER3) and others to downregulate
            activation of PER1 by CLOCK/ARNTL. Changes in this gene or its
            expression may promote prostate cancer, lung cancer, breast cancer,
            and mental disorders. Several transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Feb 2014].
            
            Transcript Variant: This variant (4) represents the longest
            transcript and encodes the longest isoform (2). Both variants 2 and
            4 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF071506.1, AB019001.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849388
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1197
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 76.49 cM"
     Protein         1..1197
                     /product="protein timeless homolog isoform 2"
                     /note="protein timeless homolog; mTim"
                     /calculated_mol_wt=137372
     Region          1..309
                     /region_name="Required for homodimerization and for
                     interaction with CRY1 and CHEK1.
                     /evidence=ECO:0000269|PubMed:23418588"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1X4.3)"
     Region          25..284
                     /region_name="TIMELESS"
                     /note="Timeless protein; pfam04821"
                     /db_xref="CDD:398476"
     Site            281
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UNS1; propagated from
                     UniProtKB/Swiss-Prot (Q9R1X4.3)"
     Region          647..674
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1X4.3)"
     Region          810..949
                     /region_name="DNA-binding domain.
                     /evidence=ECO:0000250|UniProtKB:Q9UNS1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1X4.3)"
     Region          943..1002
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1X4.3)"
     Region          997..1095
                     /region_name="Interaction with PARP1.
                     /evidence=ECO:0000250|UniProtKB:Q9UNS1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1X4.3)"
     Region          1003..1089
                     /region_name="TIMELESS_C"
                     /note="Timeless protein C terminal region; pfam05029"
                     /db_xref="CDD:398621"
     Site            1071
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UNS1; propagated from
                     UniProtKB/Swiss-Prot (Q9R1X4.3)"
     Region          1079..1197
                     /region_name="Required for nuclear localization.
                     /evidence=ECO:0000269|PubMed:23418588"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1X4.3)"
     Site            1084
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UNS1; propagated from
                     UniProtKB/Swiss-Prot (Q9R1X4.3)"
     Site            1086
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9UNS1; propagated from
                     UniProtKB/Swiss-Prot (Q9R1X4.3)"
     Region          1088..1197
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1X4.3)"
     Site            1165
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UNS1; propagated from
                     UniProtKB/Swiss-Prot (Q9R1X4.3)"
     CDS             1..1197
                     /gene="Timeless"
                     /gene_synonym="Debt69; tim"
                     /coded_by="NM_001164081.1:181..3774"
                     /note="isoform 2 is encoded by transcript variant 4"
                     /db_xref="CCDS:CCDS24266.1"
                     /db_xref="GeneID:21853"
                     /db_xref="MGI:MGI:1321393"
ORIGIN      
        1 mdlymmncel latcsalgyl eggtyhkepd clesvkdlir ylrhedetrd vrqqlgaaqi
       61 lqsdllpilt qhrqdkplfd avirlmvnlt qpallcfgsv pkdssvrhhf lqvltylqay
      121 keafasekaf gvlsetlyel lqlgwedrqe ednllieril llvrnilhvp anleqeksid
      181 ddasihdrll waihlsgmdd lllflssssa eqqwslhvle iislmfrdqt peqlagvgqg
      241 rlaqerstdv aelevlrqre maekraralq rgnrhsrfgg syivqglksi gekdvvfhkg
      301 lhnlqnyssd lgkqprrvpk rrqaaqelsv hrrsvlnvrl flrdfcsefl encynplmga
      361 vkdhllrera qqhdetyymw amaffmafnr aatfrpglvs etlsirtfhf veqnltnyye
      421 mmltdrkeaa swarrmhlal kayqellatv nemdmcpdea vressriikn nifymmeyre
      481 lflalfrkfd eryhprsflr dlvetthlfl kmlerfcrsr gnlmvqnkrk krkkkkkvqd
      541 qgvafsqspg eleamwpala eqllqcaqdp elsvdpvvpf daasevpvee qrveamvriq
      601 dcltagqapq alallrsare vwpegnafgs pvispgeemq llkqilstpl prqqepeegd
      661 aeeeeeeeee eelqvvqvse kefnfleylk rfasstivra yvlllrsyrq nsahtnhcia
      721 kmlhrlahgl gmeallfqls lfclfnrlls dpaaaaykel vtfakyiigk ffalaavnqk
      781 afvellfwkn tavvremtqg ygsldsgsss hraplwspee eaqlqelyla hkdvegqdvv
      841 etilahlkvv prtrkqvihh lvrmgladsv kefqkrkgtq ivlwtedqel elqrlfeefr
      901 dsddvlgqim knitakrsra rvvdkllalg lvserrqlyk krrkklapsc mqngeksprd
      961 pwqedpeeed ehlpedesed eeseeglpsg qgqgssslsa enlgeslrqe glsapllwlq
     1021 ssliraandr eedgcsqaip lvplteenee ameneqfqhl lrklgirpps sgqetfwrip
     1081 aklsstqlrr vaaslsqqen eeereeepep gvpgeqgpse ehrtealral lsarkrkagl
     1141 gpteeeatge eewnsapkkr qlldsdeeed degrrqavsg tprvhrkkrf qiededd
//
LOCUS       NP_035719               1197 aa            linear   ROD 07-OCT-2023
DEFINITION  protein timeless homolog isoform 2 [Mus musculus].
ACCESSION   NP_035719 XP_912611
VERSION     NP_035719.1
DBSOURCE    REFSEQ: accession NM_011589.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1197)
  AUTHORS   Barrio-Alonso E, Lituma PJ, Notaras MJ, Albero R, Bouchekioua Y,
            Wayland N, Stankovic IN, Jain T, Gao S, Calderon DP, Castillo PE
            and Colak D.
  TITLE     Circadian protein TIMELESS regulates synaptic function and memory
            by modulating cAMP signaling
  JOURNAL   Cell Rep 42 (4), 112375 (2023)
   PUBMED   37043347
  REMARK    GeneRIF: Circadian protein TIMELESS regulates synaptic function and
            memory by modulating cAMP signaling.
REFERENCE   2  (residues 1 to 1197)
  AUTHORS   Bedogni F and Hevner RF.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1197)
  AUTHORS   Kurien P, Hsu PK, Leon J, Wu D, McMahon T, Shi G, Xu Y, Lipzen A,
            Pennacchio LA, Jones CR, Fu YH and Ptacek LJ.
  TITLE     TIMELESS mutation alters phase responsiveness and causes advanced
            sleep phase
  JOURNAL   Proc Natl Acad Sci U S A 116 (24), 12045-12053 (2019)
   PUBMED   31138685
  REMARK    GeneRIF: The mutation prevents TIM accumulation in the nucleus and
            has altered affinity for CRY2.
REFERENCE   4  (residues 1 to 1197)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1197)
  AUTHORS   Inaguma Y, Ito H, Hara A, Iwamoto I, Matsumoto A, Yamagata T,
            Tabata H and Nagata K.
  TITLE     Morphological characterization of mammalian timeless in the mouse
            brain development
  JOURNAL   Neurosci Res 92, 21-28 (2015)
   PUBMED   25448545
  REMARK    GeneRIF: The obtained results suggest that Tim is expressed in
            neuronal tissues in a spatiotemporally regulated manner and
            involved in developmental stage-specific neuronal functions.
REFERENCE   6  (residues 1 to 1197)
  AUTHORS   Dunlap JC.
  TITLE     Molecular bases for circadian clocks
  JOURNAL   Cell 96 (2), 271-290 (1999)
   PUBMED   9988221
  REMARK    Review article
REFERENCE   7  (residues 1 to 1197)
  AUTHORS   Jin X, Shearman LP, Weaver DR, Zylka MJ, de Vries GJ and Reppert
            SM.
  TITLE     A molecular mechanism regulating rhythmic output from the
            suprachiasmatic circadian clock
  JOURNAL   Cell 96 (1), 57-68 (1999)
   PUBMED   9989497
REFERENCE   8  (residues 1 to 1197)
  AUTHORS   Koike N, Hida A, Numano R, Hirose M, Sakaki Y and Tei H.
  TITLE     Identification of the mammalian homologues of the Drosophila
            timeless gene, Timeless1
  JOURNAL   FEBS Lett 441 (3), 427-431 (1998)
   PUBMED   9891984
REFERENCE   9  (residues 1 to 1197)
  AUTHORS   Zylka MJ, Shearman LP, Levine JD, Jin X, Weaver DR and Reppert SM.
  TITLE     Molecular analysis of mammalian timeless
  JOURNAL   Neuron 21 (5), 1115-1122 (1998)
   PUBMED   9856466
REFERENCE   10 (residues 1 to 1197)
  AUTHORS   Sangoram AM, Saez L, Antoch MP, Gekakis N, Staknis D, Whiteley A,
            Fruechte EM, Vitaterna MH, Shimomura K, King DP, Young MW, Weitz CJ
            and Takahashi JS.
  TITLE     Mammalian circadian autoregulatory loop: a timeless ortholog and
            mPer1 interact and negatively regulate CLOCK-BMAL1-induced
            transcription
  JOURNAL   Neuron 21 (5), 1101-1113 (1998)
   PUBMED   9856465
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF098161.1 and BC082770.1.
            
            On Dec 7, 2005 this sequence version replaced XP_912611.1.
            
            Summary: The protein encoded by this gene is highly conserved and
            is involved in cell survival after damage or stress, increase in
            DNA polymerase epsilon activity, maintenance of telomere length,
            and epithelial cell morphogenesis. The encoded protein also plays a
            role in the circadian rhythm autoregulatory loop, interacting with
            the PERIOD genes (PER1, PER2, and PER3) and others to downregulate
            activation of PER1 by CLOCK/ARNTL. Changes in this gene or its
            expression may promote prostate cancer, lung cancer, breast cancer,
            and mental disorders. Several transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Feb 2014].
            
            Transcript Variant: This variant (2) represents use of an alternate
            promoter and 5' UTR, compared to variant 4. Both variants 2 and 4
            encode the same isoform (2).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF098161.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1197
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 76.49 cM"
     Protein         1..1197
                     /product="protein timeless homolog isoform 2"
                     /note="protein timeless homolog; mTim"
                     /calculated_mol_wt=137372
     Region          1..309
                     /region_name="Required for homodimerization and for
                     interaction with CRY1 and CHEK1.
                     /evidence=ECO:0000269|PubMed:23418588"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1X4.3)"
     Region          25..284
                     /region_name="TIMELESS"
                     /note="Timeless protein; pfam04821"
                     /db_xref="CDD:398476"
     Site            281
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UNS1; propagated from
                     UniProtKB/Swiss-Prot (Q9R1X4.3)"
     Region          647..674
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1X4.3)"
     Region          810..949
                     /region_name="DNA-binding domain.
                     /evidence=ECO:0000250|UniProtKB:Q9UNS1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1X4.3)"
     Region          943..1002
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1X4.3)"
     Region          997..1095
                     /region_name="Interaction with PARP1.
                     /evidence=ECO:0000250|UniProtKB:Q9UNS1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1X4.3)"
     Region          1003..1089
                     /region_name="TIMELESS_C"
                     /note="Timeless protein C terminal region; pfam05029"
                     /db_xref="CDD:398621"
     Site            1071
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UNS1; propagated from
                     UniProtKB/Swiss-Prot (Q9R1X4.3)"
     Region          1079..1197
                     /region_name="Required for nuclear localization.
                     /evidence=ECO:0000269|PubMed:23418588"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1X4.3)"
     Site            1084
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UNS1; propagated from
                     UniProtKB/Swiss-Prot (Q9R1X4.3)"
     Site            1086
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9UNS1; propagated from
                     UniProtKB/Swiss-Prot (Q9R1X4.3)"
     Region          1088..1197
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1X4.3)"
     Site            1165
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UNS1; propagated from
                     UniProtKB/Swiss-Prot (Q9R1X4.3)"
     CDS             1..1197
                     /gene="Timeless"
                     /gene_synonym="Debt69; tim"
                     /coded_by="NM_011589.2:124..3717"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS24266.1"
                     /db_xref="GeneID:21853"
                     /db_xref="MGI:MGI:1321393"
ORIGIN      
        1 mdlymmncel latcsalgyl eggtyhkepd clesvkdlir ylrhedetrd vrqqlgaaqi
       61 lqsdllpilt qhrqdkplfd avirlmvnlt qpallcfgsv pkdssvrhhf lqvltylqay
      121 keafasekaf gvlsetlyel lqlgwedrqe ednllieril llvrnilhvp anleqeksid
      181 ddasihdrll waihlsgmdd lllflssssa eqqwslhvle iislmfrdqt peqlagvgqg
      241 rlaqerstdv aelevlrqre maekraralq rgnrhsrfgg syivqglksi gekdvvfhkg
      301 lhnlqnyssd lgkqprrvpk rrqaaqelsv hrrsvlnvrl flrdfcsefl encynplmga
      361 vkdhllrera qqhdetyymw amaffmafnr aatfrpglvs etlsirtfhf veqnltnyye
      421 mmltdrkeaa swarrmhlal kayqellatv nemdmcpdea vressriikn nifymmeyre
      481 lflalfrkfd eryhprsflr dlvetthlfl kmlerfcrsr gnlmvqnkrk krkkkkkvqd
      541 qgvafsqspg eleamwpala eqllqcaqdp elsvdpvvpf daasevpvee qrveamvriq
      601 dcltagqapq alallrsare vwpegnafgs pvispgeemq llkqilstpl prqqepeegd
      661 aeeeeeeeee eelqvvqvse kefnfleylk rfasstivra yvlllrsyrq nsahtnhcia
      721 kmlhrlahgl gmeallfqls lfclfnrlls dpaaaaykel vtfakyiigk ffalaavnqk
      781 afvellfwkn tavvremtqg ygsldsgsss hraplwspee eaqlqelyla hkdvegqdvv
      841 etilahlkvv prtrkqvihh lvrmgladsv kefqkrkgtq ivlwtedqel elqrlfeefr
      901 dsddvlgqim knitakrsra rvvdkllalg lvserrqlyk krrkklapsc mqngeksprd
      961 pwqedpeeed ehlpedesed eeseeglpsg qgqgssslsa enlgeslrqe glsapllwlq
     1021 ssliraandr eedgcsqaip lvplteenee ameneqfqhl lrklgirpps sgqetfwrip
     1081 aklsstqlrr vaaslsqqen eeereeepep gvpgeqgpse ehrtealral lsarkrkagl
     1141 gpteeeatge eewnsapkkr qlldsdeeed degrrqavsg tprvhrkkrf qiededd
//
LOCUS       NP_001096035             389 aa            linear   ROD 07-OCT-2023
DEFINITION  nucleic acid dioxygenase ALKBH1 [Mus musculus].
ACCESSION   NP_001096035
VERSION     NP_001096035.1
DBSOURCE    REFSEQ: accession NM_001102565.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 389)
  AUTHORS   Wang X, Wong CC, Chen H, Fu K, Shi L, Su H, Guo S, Gou H, Hu X,
            Zhang L, Ji J and Yu J.
  TITLE     The N6-methyladenine DNA demethylase ALKBH1 promotes gastric
            carcinogenesis by disrupting NRF1 binding capacity
  JOURNAL   Cell Rep 42 (3), 112279 (2023)
   PUBMED   36989111
  REMARK    GeneRIF: The N[6]-methyladenine DNA demethylase ALKBH1 promotes
            gastric carcinogenesis by disrupting NRF1 binding capacity.
REFERENCE   2  (residues 1 to 389)
  AUTHORS   Cai GP, Liu YL, Luo LP, Xiao Y, Jiang TJ, Yuan J and Wang M.
  TITLE     Alkbh1-mediated DNA N6-methyladenine modification regulates bone
            marrow mesenchymal stem cell fate during skeletal aging
  JOURNAL   Cell Prolif 55 (2), e13178 (2022)
   PUBMED   35018683
  REMARK    GeneRIF: Alkbh1-mediated DNA N6-methyladenine modification
            regulates bone marrow mesenchymal stem cell fate during skeletal
            aging.
REFERENCE   3  (residues 1 to 389)
  AUTHORS   Luo L, Liu Y, Nizigiyimana P, Ye M, Xiao Y, Guo Q, Su T, Luo X,
            Huang Y and Zhou H.
  TITLE     DNA 6mA Demethylase ALKBH1 Orchestrates Fatty Acid Metabolism and
            Suppresses Diet-Induced Hepatic Steatosis
  JOURNAL   Cell Mol Gastroenterol Hepatol 14 (6), 1213-1233 (2022)
   PUBMED   36058506
  REMARK    GeneRIF: DNA 6mA Demethylase ALKBH1 Orchestrates Fatty Acid
            Metabolism and Suppresses Diet-Induced Hepatic Steatosis.
REFERENCE   4  (residues 1 to 389)
  AUTHORS   Ouyang L, Su X, Li W, Tang L, Zhang M, Zhu Y, Xie C, Zhang P, Chen
            J and Huang H.
  TITLE     ALKBH1-demethylated DNA N6-methyladenine modification triggers
            vascular calcification via osteogenic reprogramming in chronic
            kidney disease
  JOURNAL   J Clin Invest 131 (14) (2021)
   PUBMED   34003800
  REMARK    GeneRIF: ALKBH1-demethylated DNA N6-methyladenine modification
            triggers vascular calcification via osteogenic reprogramming in
            chronic kidney disease.
REFERENCE   5  (residues 1 to 389)
  AUTHORS   Diao LT, Xie SJ, Yu PJ, Sun YJ, Yang F, Tan YY, Tao S, Hou YR,
            Zheng LL, Xiao ZD and Zhang Q.
  TITLE     N6-methyladenine demethylase ALKBH1 inhibits the differentiation of
            skeletal muscle
  JOURNAL   Exp Cell Res 400 (2), 112492 (2021)
   PUBMED   33529710
REFERENCE   6  (residues 1 to 389)
  AUTHORS   Ougland R, Lando D, Jonson I, Dahl JA, Moen MN, Nordstrand LM,
            Rognes T, Lee JT, Klungland A, Kouzarides T and Larsen E.
  TITLE     ALKBH1 is a histone H2A dioxygenase involved in neural
            differentiation
  JOURNAL   Stem Cells 30 (12), 2672-2682 (2012)
   PUBMED   22961808
  REMARK    GeneRIF: Results suggest that ALKBH1 is involved in neural
            development by modifying the methylation status of histone H2A.
REFERENCE   7  (residues 1 to 389)
  AUTHORS   Nordstrand LM, Svard J, Larsen E, Nilsen A, Ougland R, Furu K, Lien
            GF, Rognes T, Namekawa SH, Lee JT and Klungland A.
  TITLE     Mice lacking Alkbh1 display sex-ratio distortion and unilateral eye
            defects
  JOURNAL   PLoS One 5 (11), e13827 (2010)
   PUBMED   21072209
  REMARK    GeneRIF: Data suggest that Alkbh1 mediates gene regulation in
            spermatogenesis, and that Alkbh1 is essential for normal sex-ratio
            distribution and embryonic development.
            Publication Status: Online-Only
REFERENCE   8  (residues 1 to 389)
  AUTHORS   Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X,
            Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y,
            Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague
            B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R,
            Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K,
            Eichler EE and Ponting CP.
  CONSRTM   Mouse Genome Sequencing Consortium
  TITLE     Lineage-specific biology revealed by a finished genome assembly of
            the mouse
  JOURNAL   PLoS Biol 7 (5), e1000112 (2009)
   PUBMED   19468303
REFERENCE   9  (residues 1 to 389)
  AUTHORS   Pan Z, Sikandar S, Witherspoon M, Dizon D, Nguyen T, Benirschke K,
            Wiley C, Vrana P and Lipkin SM.
  TITLE     Impaired placental trophoblast lineage differentiation in
            Alkbh1(-/-) mice
  JOURNAL   Dev Dyn 237 (2), 316-327 (2008)
   PUBMED   18163532
  REMARK    GeneRIF: Alkbh1 performs important functions in placental
            trophoblast lineage differentiation and participates in mechanisms
            of transcriptional regulation.
REFERENCE   10 (residues 1 to 389)
  AUTHORS   Gorba T, Bradoo P, Antonic A, Marvin K, Liu DX, Lobie PE, Reymann
            KG, Gluckman PD and Sieg F.
  TITLE     Neural regeneration protein is a novel chemoattractive and neuronal
            survival-promoting factor
  JOURNAL   Exp Cell Res 312 (16), 3060-3074 (2006)
   PUBMED   16860792
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK144828.1 and BC094381.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144828.1, SRR1660815.220444.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..389
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 41.65 cM"
     Protein         1..389
                     /product="nucleic acid dioxygenase ALKBH1"
                     /EC_number="4.2.99.18"
                     /EC_number="1.14.11.33"
                     /EC_number="1.14.11.51"
                     /note="Alkylated DNA repair protein alkB homolog 1; DNA
                     lyase ABH1; alpha-ketoglutarate-dependent dioxygenase
                     ABH1; DNA oxidative demethylase ALKBH1; alkB, alkylation
                     repair homolog 1; DNA 6mA demethylase; DNA demethylase
                     ALKBH1; tRNA N1-methyl adenine demethylase; mRNA
                     N(3)-methylcytidine demethylase; DNA N6-methyl adenine
                     demethylase ALKBH1"
                     /calculated_mol_wt=43615
     Region          1..127
                     /region_name="Interaction with DNAJB6.
                     /evidence=ECO:0000269|PubMed:18163532"
                     /note="propagated from UniProtKB/Swiss-Prot (P0CB42.1)"
     Region          86..389
                     /region_name="tRNA-binding.
                     /evidence=ECO:0000250|UniProtKB:Q13686"
                     /note="propagated from UniProtKB/Swiss-Prot (P0CB42.1)"
     Region          119..289
                     /region_name="2OG-FeII_Oxy"
                     /note="2OG-Fe(II) oxygenase superfamily; cl21496"
                     /db_xref="CDD:451274"
     CDS             1..389
                     /gene="Alkbh1"
                     /gene_synonym="2700073G19Rik; Abh; alkB; Alkbh; hABH"
                     /coded_by="NM_001102565.1:16..1185"
                     /db_xref="CCDS:CCDS49120.1"
                     /db_xref="GeneID:211064"
                     /db_xref="MGI:MGI:2384034"
ORIGIN      
        1 mgkmaaavas latlaaepre dafrklfrfy rqsrpgtadl gavidfseah larspkpgvp
       61 qvvrfplnvs svterdaerv glepvskwra yglegypgfi fipnpflpgc qrhwvkqclk
      121 lysqkpnvcn ldkhmtkeet qglweqskev lrskevtkrr prsllerlrw vtlgyhynwd
      181 skkysadhyt pfpsdlafls eqvatacgfq gfqaeagiln yyrldstlgi hvdrseldhs
      241 kpllsfsfgq saifllgglk rdeaptamfm hsgdimvmsg fsrllnhavp rvlphpdgec
      301 lphcletplp avlpsnslve pcsvedwqvc atylrtarvn mtvrqvlatg qdfplepvee
      361 tkrdiaadgl chlhdpnspv krkrlnpns
//
LOCUS       NP_001157552            1196 aa            linear   ROD 07-OCT-2023
DEFINITION  protein timeless homolog isoform 3 [Mus musculus].
ACCESSION   NP_001157552
VERSION     NP_001157552.1
DBSOURCE    REFSEQ: accession NM_001164080.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1196)
  AUTHORS   Barrio-Alonso E, Lituma PJ, Notaras MJ, Albero R, Bouchekioua Y,
            Wayland N, Stankovic IN, Jain T, Gao S, Calderon DP, Castillo PE
            and Colak D.
  TITLE     Circadian protein TIMELESS regulates synaptic function and memory
            by modulating cAMP signaling
  JOURNAL   Cell Rep 42 (4), 112375 (2023)
   PUBMED   37043347
  REMARK    GeneRIF: Circadian protein TIMELESS regulates synaptic function and
            memory by modulating cAMP signaling.
REFERENCE   2  (residues 1 to 1196)
  AUTHORS   Bedogni F and Hevner RF.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1196)
  AUTHORS   Kurien P, Hsu PK, Leon J, Wu D, McMahon T, Shi G, Xu Y, Lipzen A,
            Pennacchio LA, Jones CR, Fu YH and Ptacek LJ.
  TITLE     TIMELESS mutation alters phase responsiveness and causes advanced
            sleep phase
  JOURNAL   Proc Natl Acad Sci U S A 116 (24), 12045-12053 (2019)
   PUBMED   31138685
  REMARK    GeneRIF: The mutation prevents TIM accumulation in the nucleus and
            has altered affinity for CRY2.
REFERENCE   4  (residues 1 to 1196)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1196)
  AUTHORS   Inaguma Y, Ito H, Hara A, Iwamoto I, Matsumoto A, Yamagata T,
            Tabata H and Nagata K.
  TITLE     Morphological characterization of mammalian timeless in the mouse
            brain development
  JOURNAL   Neurosci Res 92, 21-28 (2015)
   PUBMED   25448545
  REMARK    GeneRIF: The obtained results suggest that Tim is expressed in
            neuronal tissues in a spatiotemporally regulated manner and
            involved in developmental stage-specific neuronal functions.
REFERENCE   6  (residues 1 to 1196)
  AUTHORS   Dunlap JC.
  TITLE     Molecular bases for circadian clocks
  JOURNAL   Cell 96 (2), 271-290 (1999)
   PUBMED   9988221
  REMARK    Review article
REFERENCE   7  (residues 1 to 1196)
  AUTHORS   Jin X, Shearman LP, Weaver DR, Zylka MJ, de Vries GJ and Reppert
            SM.
  TITLE     A molecular mechanism regulating rhythmic output from the
            suprachiasmatic circadian clock
  JOURNAL   Cell 96 (1), 57-68 (1999)
   PUBMED   9989497
REFERENCE   8  (residues 1 to 1196)
  AUTHORS   Koike N, Hida A, Numano R, Hirose M, Sakaki Y and Tei H.
  TITLE     Identification of the mammalian homologues of the Drosophila
            timeless gene, Timeless1
  JOURNAL   FEBS Lett 441 (3), 427-431 (1998)
   PUBMED   9891984
REFERENCE   9  (residues 1 to 1196)
  AUTHORS   Zylka MJ, Shearman LP, Levine JD, Jin X, Weaver DR and Reppert SM.
  TITLE     Molecular analysis of mammalian timeless
  JOURNAL   Neuron 21 (5), 1115-1122 (1998)
   PUBMED   9856466
REFERENCE   10 (residues 1 to 1196)
  AUTHORS   Sangoram AM, Saez L, Antoch MP, Gekakis N, Staknis D, Whiteley A,
            Fruechte EM, Vitaterna MH, Shimomura K, King DP, Young MW, Weitz CJ
            and Takahashi JS.
  TITLE     Mammalian circadian autoregulatory loop: a timeless ortholog and
            mPer1 interact and negatively regulate CLOCK-BMAL1-induced
            transcription
  JOURNAL   Neuron 21 (5), 1101-1113 (1998)
   PUBMED   9856465
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC052884.1, AK153838.1 and BC082770.1.
            
            Summary: The protein encoded by this gene is highly conserved and
            is involved in cell survival after damage or stress, increase in
            DNA polymerase epsilon activity, maintenance of telomere length,
            and epithelial cell morphogenesis. The encoded protein also plays a
            role in the circadian rhythm autoregulatory loop, interacting with
            the PERIOD genes (PER1, PER2, and PER3) and others to downregulate
            activation of PER1 by CLOCK/ARNTL. Changes in this gene or its
            expression may promote prostate cancer, lung cancer, breast cancer,
            and mental disorders. Several transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Feb 2014].
            
            Transcript Variant: This variant (3) uses an alternate in-frame
            splice site in the 3' coding region, compared to variant 4. The
            resulting isoform (3) lacks one aa near the C-terminus, compared to
            isoform 2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK153838.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849388
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1196
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 76.49 cM"
     Protein         1..1196
                     /product="protein timeless homolog isoform 3"
                     /note="protein timeless homolog; mTim"
                     /calculated_mol_wt=137301
     Region          1..309
                     /region_name="Required for homodimerization and for
                     interaction with CRY1 and CHEK1.
                     /evidence=ECO:0000269|PubMed:23418588"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1X4.3)"
     Region          24..284
                     /region_name="TIMELESS"
                     /note="Timeless protein; pfam04821"
                     /db_xref="CDD:428142"
     Site            281
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UNS1; propagated from
                     UniProtKB/Swiss-Prot (Q9R1X4.3)"
     Region          647..674
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1X4.3)"
     Region          810..949
                     /region_name="DNA-binding domain.
                     /evidence=ECO:0000250|UniProtKB:Q9UNS1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1X4.3)"
     Region          943..1002
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1X4.3)"
     Region          997..1095
                     /region_name="Interaction with PARP1.
                     /evidence=ECO:0000250|UniProtKB:Q9UNS1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1X4.3)"
     Region          1003..1089
                     /region_name="TIMELESS_C"
                     /note="Timeless protein C terminal region; pfam05029"
                     /db_xref="CDD:428267"
     Site            1071
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UNS1; propagated from
                     UniProtKB/Swiss-Prot (Q9R1X4.3)"
     Site            1084
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UNS1; propagated from
                     UniProtKB/Swiss-Prot (Q9R1X4.3)"
     Site            1086
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9UNS1; propagated from
                     UniProtKB/Swiss-Prot (Q9R1X4.3)"
     Site            1165
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UNS1; propagated from
                     UniProtKB/Swiss-Prot (Q9R1X4.3)"
     CDS             1..1196
                     /gene="Timeless"
                     /gene_synonym="Debt69; tim"
                     /coded_by="NM_001164080.1:181..3771"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS48724.1"
                     /db_xref="GeneID:21853"
                     /db_xref="MGI:MGI:1321393"
ORIGIN      
        1 mdlymmncel latcsalgyl eggtyhkepd clesvkdlir ylrhedetrd vrqqlgaaqi
       61 lqsdllpilt qhrqdkplfd avirlmvnlt qpallcfgsv pkdssvrhhf lqvltylqay
      121 keafasekaf gvlsetlyel lqlgwedrqe ednllieril llvrnilhvp anleqeksid
      181 ddasihdrll waihlsgmdd lllflssssa eqqwslhvle iislmfrdqt peqlagvgqg
      241 rlaqerstdv aelevlrqre maekraralq rgnrhsrfgg syivqglksi gekdvvfhkg
      301 lhnlqnyssd lgkqprrvpk rrqaaqelsv hrrsvlnvrl flrdfcsefl encynplmga
      361 vkdhllrera qqhdetyymw amaffmafnr aatfrpglvs etlsirtfhf veqnltnyye
      421 mmltdrkeaa swarrmhlal kayqellatv nemdmcpdea vressriikn nifymmeyre
      481 lflalfrkfd eryhprsflr dlvetthlfl kmlerfcrsr gnlmvqnkrk krkkkkkvqd
      541 qgvafsqspg eleamwpala eqllqcaqdp elsvdpvvpf daasevpvee qrveamvriq
      601 dcltagqapq alallrsare vwpegnafgs pvispgeemq llkqilstpl prqqepeegd
      661 aeeeeeeeee eelqvvqvse kefnfleylk rfasstivra yvlllrsyrq nsahtnhcia
      721 kmlhrlahgl gmeallfqls lfclfnrlls dpaaaaykel vtfakyiigk ffalaavnqk
      781 afvellfwkn tavvremtqg ygsldsgsss hraplwspee eaqlqelyla hkdvegqdvv
      841 etilahlkvv prtrkqvihh lvrmgladsv kefqkrkgtq ivlwtedqel elqrlfeefr
      901 dsddvlgqim knitakrsra rvvdkllalg lvserrqlyk krrkklapsc mqngeksprd
      961 pwqedpeeed ehlpedesed eeseeglpsg qgqgssslsa enlgeslrqe glsapllwlq
     1021 ssliraandr eedgcsqaip lvplteenee ameneqfqhl lrklgirpps sgqetfwrip
     1081 aklsstqlrr vaaslsqqen eeereeepep gvpgeqgpse ehrtealral lsarkrkagl
     1141 gpteeeatge eewnsapkkr qlldsdeeed degrrqvsgt prvhrkkrfq iededd
//
LOCUS       NP_001129554            1196 aa            linear   ROD 07-OCT-2023
DEFINITION  protein timeless homolog isoform 1 [Mus musculus].
ACCESSION   NP_001129554
VERSION     NP_001129554.1
DBSOURCE    REFSEQ: accession NM_001136082.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1196)
  AUTHORS   Barrio-Alonso E, Lituma PJ, Notaras MJ, Albero R, Bouchekioua Y,
            Wayland N, Stankovic IN, Jain T, Gao S, Calderon DP, Castillo PE
            and Colak D.
  TITLE     Circadian protein TIMELESS regulates synaptic function and memory
            by modulating cAMP signaling
  JOURNAL   Cell Rep 42 (4), 112375 (2023)
   PUBMED   37043347
  REMARK    GeneRIF: Circadian protein TIMELESS regulates synaptic function and
            memory by modulating cAMP signaling.
REFERENCE   2  (residues 1 to 1196)
  AUTHORS   Bedogni F and Hevner RF.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1196)
  AUTHORS   Kurien P, Hsu PK, Leon J, Wu D, McMahon T, Shi G, Xu Y, Lipzen A,
            Pennacchio LA, Jones CR, Fu YH and Ptacek LJ.
  TITLE     TIMELESS mutation alters phase responsiveness and causes advanced
            sleep phase
  JOURNAL   Proc Natl Acad Sci U S A 116 (24), 12045-12053 (2019)
   PUBMED   31138685
  REMARK    GeneRIF: The mutation prevents TIM accumulation in the nucleus and
            has altered affinity for CRY2.
REFERENCE   4  (residues 1 to 1196)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1196)
  AUTHORS   Inaguma Y, Ito H, Hara A, Iwamoto I, Matsumoto A, Yamagata T,
            Tabata H and Nagata K.
  TITLE     Morphological characterization of mammalian timeless in the mouse
            brain development
  JOURNAL   Neurosci Res 92, 21-28 (2015)
   PUBMED   25448545
  REMARK    GeneRIF: The obtained results suggest that Tim is expressed in
            neuronal tissues in a spatiotemporally regulated manner and
            involved in developmental stage-specific neuronal functions.
REFERENCE   6  (residues 1 to 1196)
  AUTHORS   Dunlap JC.
  TITLE     Molecular bases for circadian clocks
  JOURNAL   Cell 96 (2), 271-290 (1999)
   PUBMED   9988221
  REMARK    Review article
REFERENCE   7  (residues 1 to 1196)
  AUTHORS   Jin X, Shearman LP, Weaver DR, Zylka MJ, de Vries GJ and Reppert
            SM.
  TITLE     A molecular mechanism regulating rhythmic output from the
            suprachiasmatic circadian clock
  JOURNAL   Cell 96 (1), 57-68 (1999)
   PUBMED   9989497
REFERENCE   8  (residues 1 to 1196)
  AUTHORS   Koike N, Hida A, Numano R, Hirose M, Sakaki Y and Tei H.
  TITLE     Identification of the mammalian homologues of the Drosophila
            timeless gene, Timeless1
  JOURNAL   FEBS Lett 441 (3), 427-431 (1998)
   PUBMED   9891984
REFERENCE   9  (residues 1 to 1196)
  AUTHORS   Zylka MJ, Shearman LP, Levine JD, Jin X, Weaver DR and Reppert SM.
  TITLE     Molecular analysis of mammalian timeless
  JOURNAL   Neuron 21 (5), 1115-1122 (1998)
   PUBMED   9856466
REFERENCE   10 (residues 1 to 1196)
  AUTHORS   Sangoram AM, Saez L, Antoch MP, Gekakis N, Staknis D, Whiteley A,
            Fruechte EM, Vitaterna MH, Shimomura K, King DP, Young MW, Weitz CJ
            and Takahashi JS.
  TITLE     Mammalian circadian autoregulatory loop: a timeless ortholog and
            mPer1 interact and negatively regulate CLOCK-BMAL1-induced
            transcription
  JOURNAL   Neuron 21 (5), 1101-1113 (1998)
   PUBMED   9856465
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC052884.1 and BC082770.1.
            
            Summary: The protein encoded by this gene is highly conserved and
            is involved in cell survival after damage or stress, increase in
            DNA polymerase epsilon activity, maintenance of telomere length,
            and epithelial cell morphogenesis. The encoded protein also plays a
            role in the circadian rhythm autoregulatory loop, interacting with
            the PERIOD genes (PER1, PER2, and PER3) and others to downregulate
            activation of PER1 by CLOCK/ARNTL. Changes in this gene or its
            expression may promote prostate cancer, lung cancer, breast cancer,
            and mental disorders. Several transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Feb 2014].
            
            Transcript Variant: This variant (1) uses an alternate in-frame
            splice site in the 3' coding region, compared to variant 4. This
            variant is distinct from but the same length as variant 3. The
            resulting isoform (1) lacks one aa near the C-terminus, compared to
            isoform 2, and is distinct from isoform 3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC082770.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1196
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 76.49 cM"
     Protein         1..1196
                     /product="protein timeless homolog isoform 1"
                     /note="protein timeless homolog; mTim"
                     /calculated_mol_wt=137244
     Region          1..309
                     /region_name="Required for homodimerization and for
                     interaction with CRY1 and CHEK1.
                     /evidence=ECO:0000269|PubMed:23418588"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1X4.3)"
     Region          24..284
                     /region_name="TIMELESS"
                     /note="Timeless protein; pfam04821"
                     /db_xref="CDD:428142"
     Site            281
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UNS1; propagated from
                     UniProtKB/Swiss-Prot (Q9R1X4.3)"
     Region          647..674
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1X4.3)"
     Region          810..949
                     /region_name="DNA-binding domain.
                     /evidence=ECO:0000250|UniProtKB:Q9UNS1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1X4.3)"
     Region          996..1094
                     /region_name="Interaction with PARP1.
                     /evidence=ECO:0000250|UniProtKB:Q9UNS1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1X4.3)"
     Region          1002..1088
                     /region_name="TIMELESS_C"
                     /note="Timeless protein C terminal region; pfam05029"
                     /db_xref="CDD:428267"
     Site            1070
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UNS1; propagated from
                     UniProtKB/Swiss-Prot (Q9R1X4.3)"
     Region          1078..1196
                     /region_name="Required for nuclear localization.
                     /evidence=ECO:0000269|PubMed:23418588"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1X4.3)"
     Site            1083
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UNS1; propagated from
                     UniProtKB/Swiss-Prot (Q9R1X4.3)"
     Site            1085
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9UNS1; propagated from
                     UniProtKB/Swiss-Prot (Q9R1X4.3)"
     Region          1087..1196
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1X4.3)"
     Site            1164
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UNS1; propagated from
                     UniProtKB/Swiss-Prot (Q9R1X4.3)"
     CDS             1..1196
                     /gene="Timeless"
                     /gene_synonym="Debt69; tim"
                     /coded_by="NM_001136082.2:181..3771"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS48725.1"
                     /db_xref="GeneID:21853"
                     /db_xref="MGI:MGI:1321393"
ORIGIN      
        1 mdlymmncel latcsalgyl eggtyhkepd clesvkdlir ylrhedetrd vrqqlgaaqi
       61 lqsdllpilt qhrqdkplfd avirlmvnlt qpallcfgsv pkdssvrhhf lqvltylqay
      121 keafasekaf gvlsetlyel lqlgwedrqe ednllieril llvrnilhvp anleqeksid
      181 ddasihdrll waihlsgmdd lllflssssa eqqwslhvle iislmfrdqt peqlagvgqg
      241 rlaqerstdv aelevlrqre maekraralq rgnrhsrfgg syivqglksi gekdvvfhkg
      301 lhnlqnyssd lgkqprrvpk rrqaaqelsv hrrsvlnvrl flrdfcsefl encynplmga
      361 vkdhllrera qqhdetyymw amaffmafnr aatfrpglvs etlsirtfhf veqnltnyye
      421 mmltdrkeaa swarrmhlal kayqellatv nemdmcpdea vressriikn nifymmeyre
      481 lflalfrkfd eryhprsflr dlvetthlfl kmlerfcrsr gnlmvqnkrk krkkkkkvqd
      541 qgvafsqspg eleamwpala eqllqcaqdp elsvdpvvpf daasevpvee qrveamvriq
      601 dcltagqapq alallrsare vwpegnafgs pvispgeemq llkqilstpl prqqepeegd
      661 aeeeeeeeee eelqvvqvse kefnfleylk rfasstivra yvlllrsyrq nsahtnhcia
      721 kmlhrlahgl gmeallfqls lfclfnrlls dpaaaaykel vtfakyiigk ffalaavnqk
      781 afvellfwkn tavvremtqg ygsldsgsss hraplwspee eaqlqelyla hkdvegqdvv
      841 etilahlkvv prtrkqvihh lvrmgladsv kefqkrkgtq ivlwtedqel elqrlfeefr
      901 dsddvlgqim knitakrsra rvvdkllalg lvserrqlyk krrkklapsc mngeksprdp
      961 wqedpeeede hlpedesede eseeglpsgq gqgssslsae nlgeslrqeg lsapllwlqs
     1021 sliraandre edgcsqaipl vplteeneea meneqfqhll rklgirppss gqetfwripa
     1081 klsstqlrrv aaslsqqene eereeepepg vpgeqgpsee hrtealrall sarkrkaglg
     1141 pteeeatgee ewnsapkkrq lldsdeeedd egrrqavsgt prvhrkkrfq iededd
//
LOCUS       NP_032079                539 aa            linear   ROD 07-OCT-2023
DEFINITION  RNA-binding protein FXR1 isoform 3 [Mus musculus].
ACCESSION   NP_032079
VERSION     NP_032079.1
DBSOURCE    REFSEQ: accession NM_008053.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 539)
  AUTHORS   Zhou GF, Tang J, Ma YL, Fu X, Liu JY, Yang RZ, Zhang HS, Cai XH,
            Wang JW, Xie XY, Song L, Luo B, Chen J, Chen L, Deng XJ and Chen
            GJ.
  TITLE     ARL6IP1 mediates small-molecule-induced alleviation of Alzheimer
            pathology through FXR1-dependent BACE1 translation initiation
  JOURNAL   Proc Natl Acad Sci U S A 120 (22), e2220148120 (2023)
   PUBMED   37216506
  REMARK    GeneRIF: ARL6IP1 mediates small-molecule-induced alleviation of
            Alzheimer pathology through FXR1-dependent BACE1 translation
            initiation.
REFERENCE   2  (residues 1 to 539)
  AUTHORS   Corbett CB, St Paul A, Leigh T, Kelemen SE, Peluzzo AM, Okune RN,
            Eguchi S, Haines DS and Autieri MV.
  TITLE     Genetic Deletion of FXR1 Reduces Intimal Hyperplasia and Induces
            Senescence in Vascular Smooth Muscle Cells
  JOURNAL   Am J Pathol 193 (5), 638-653 (2023)
   PUBMED   37080662
  REMARK    GeneRIF: Genetic Deletion of FXR1 Reduces Intimal Hyperplasia and
            Induces Senescence in Vascular Smooth Muscle Cells.
REFERENCE   3  (residues 1 to 539)
  AUTHORS   St Paul A, Corbett C, Peluzzo A, Kelemen S, Okune R, Haines DS,
            Preston K, Eguchi S and Autieri MV.
  TITLE     FXR1 regulates vascular smooth muscle cell cytoskeleton, VSMC
            contractility, and blood pressure by multiple mechanisms
  JOURNAL   Cell Rep 42 (4), 112381 (2023)
   PUBMED   37043351
REFERENCE   4  (residues 1 to 539)
  AUTHORS   Kang JY, Wen Z, Pan D, Zhang Y, Li Q, Zhong A, Yu X, Wu YC, Chen Y,
            Zhang X, Kou PC, Geng J, Wang YY, Hua MM, Zong R, Li B, Shi HJ, Li
            D, Fu XD, Li J, Nelson DL, Guo X, Zhou Y, Gou LT, Huang Y and Liu
            MF.
  TITLE     LLPS of FXR1 drives spermiogenesis by activating translation of
            stored mRNAs
  JOURNAL   Science 377 (6607), eabj6647 (2022)
   PUBMED   35951695
  REMARK    GeneRIF: LLPS of FXR1 drives spermiogenesis by activating
            translation of stored mRNAs.
REFERENCE   5  (residues 1 to 539)
  AUTHORS   Khamoui AV, Tokmina-Roszyk D, Feresin RG, Fields GB and Visavadiya
            NP.
  TITLE     Skeletal muscle proteome expression differentiates severity of
            cancer cachexia in mice and identifies loss of fragile X mental
            retardation syndrome-related protein 1
  JOURNAL   Proteomics 22 (10), e2100157 (2022)
   PUBMED   35289490
  REMARK    GeneRIF: Skeletal muscle proteome expression differentiates
            severity of cancer cachexia in mice and identifies loss of fragile
            X mental retardation syndrome-related protein 1.
REFERENCE   6  (residues 1 to 539)
  AUTHORS   Schenck A, Bardoni B, Moro A, Bagni C and Mandel JL.
  TITLE     A highly conserved protein family interacting with the fragile X
            mental retardation protein (FMRP) and displaying selective
            interactions with FMRP-related proteins FXR1P and FXR2P
  JOURNAL   Proc Natl Acad Sci U S A 98 (15), 8844-8849 (2001)
   PUBMED   11438699
REFERENCE   7  (residues 1 to 539)
  AUTHORS   Dube M, Huot ME and Khandjian EW.
  TITLE     Muscle specific fragile X related protein 1 isoforms are
            sequestered in the nucleus of undifferentiated myoblast
  JOURNAL   BMC Genet 1, 4 (2000)
   PUBMED   11178106
  REMARK    GeneRIF: Four FXR1 isoforms of molecular weight 70, 74, 78, 80 kDa
            are widely distributed in mouse organs, while in striated muscles
            these isoforms are replaced by proteins of 82 and 84 kDa containing
            an extra pocket of 27 amino acids.
REFERENCE   8  (residues 1 to 539)
  AUTHORS   Ceman S, Brown V and Warren ST.
  TITLE     Isolation of an FMRP-associated messenger ribonucleoprotein
            particle and identification of nucleolin and the fragile X-related
            proteins as components of the complex
  JOURNAL   Mol Cell Biol 19 (12), 7925-7932 (1999)
   PUBMED   10567518
REFERENCE   9  (residues 1 to 539)
  AUTHORS   Kirkpatrick LL, McIlwain KA and Nelson DL.
  TITLE     Alternative splicing in the murine and human FXR1 genes
  JOURNAL   Genomics 59 (2), 193-202 (1999)
   PUBMED   10409431
REFERENCE   10 (residues 1 to 539)
  AUTHORS   Coy JF, Sedlacek Z, Bachner D, Hameister H, Joos S, Lichter P,
            Delius H and Poustka A.
  TITLE     Highly conserved 3' UTR and expression pattern of FXR1 points to a
            divergent gene regulation of FXR1 and FMR1
  JOURNAL   Hum Mol Genet 4 (12), 2209-2218 (1995)
   PUBMED   8634689
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115078.11 and AC068294.26.
            
            Transcript Variant: This variant (3) differs in the 3' UTR, and
            lacks an alternate in-frame segment in the mid-coding region and
            two alternate exons in the 3' coding region, compared to variant 1.
            The resulting protein (isoform 3, also known as isoform a) contains
            a distinct C-terminus and is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC019139.1, X90875.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..539
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 16.41 cM"
     Protein         1..539
                     /product="RNA-binding protein FXR1 isoform 3"
                     /note="RNA-binding protein FXR1"
                     /calculated_mol_wt=60685
     Region          3..57
                     /region_name="Tudor_Agenet_FXR1_rpt1"
                     /note="first Tudor-like Agenet domain found in fragile X
                     mental retardation syndrome-related protein 1 (FXR1) and
                     similar proteins; cd20472"
                     /db_xref="CDD:410543"
     Site            order(10,14,16,32,36,38)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410543"
     Region          61..126
                     /region_name="Tudor_Agenet_FXR1_rpt2"
                     /note="second Tudor-like Agenet domain found in fragile X
                     mental retardation syndrome-related protein 1 (FXR1) and
                     similar proteins; cd20475"
                     /db_xref="CDD:410546"
     Site            order(69,78,80,96,101,103)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:410546"
     Region          123..199
                     /region_name="KH_I_FXR1_rpt1"
                     /note="first type I K homology (KH) RNA-binding domain
                     found in fragile X mental retardation syndrome-related
                     protein 1 (FXR1) and similar proteins; cd22504"
                     /db_xref="CDD:411932"
     Region          218..280
                     /region_name="KH_I_FXR1_rpt2"
                     /note="second type I K homology (KH) RNA-binding domain
                     found in fragile X mental retardation syndrome-related
                     protein 1 (FXR1) and similar proteins; cd22507"
                     /db_xref="CDD:411935"
     Site            order(228,230..232,234..238,241..242,245..246,252..255)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:411935"
     Site            235..238
                     /site_type="other"
                     /note="GXXG motif"
                     /db_xref="CDD:411935"
     Region          281..358
                     /region_name="KH_I_FXR1_rpt3"
                     /note="third type I K homology (KH) RNA-binding domain
                     found in fragile X mental retardation syndrome-related
                     protein 1 (FXR1) and similar proteins; cd22510"
                     /db_xref="CDD:411938"
     Site            order(291,293..295,297..301,304..305,308..309,315..318)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:411938"
     Site            298..301
                     /site_type="other"
                     /note="GXXG motif"
                     /db_xref="CDD:411938"
     Region          354..438
                     /region_name="FXMRP1_C_core"
                     /note="Fragile X-related 1 protein core C terminal;
                     pfam12235"
                     /db_xref="CDD:432414"
     Region          462..535
                     /region_name="FXR_C1"
                     /note="Fragile X-related 1 protein C-terminal region 2;
                     pfam16096"
                     /db_xref="CDD:435133"
     CDS             1..539
                     /gene="Fxr1"
                     /gene_synonym="1110050J02Rik; 9530073J07Rik; Fxr1h; Fxr1p"
                     /coded_by="NM_008053.3:16..1635"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS50890.1"
                     /db_xref="GeneID:14359"
                     /db_xref="MGI:MGI:104860"
ORIGIN      
        1 maeltvevrg sngafykgfi kdvhedsltv vfennwqper qvpfnevrlp pppdikkeis
       61 egdevevysr andqepcgww lakvrmmkge fyvieyaacd atyneivtfe rlrpvnqnkt
      121 vkkntffkct vdvpedlrea canenahkdf kkavgacrif yhpettqlmi lsaseatvkr
      181 vnilsdmhlr sirtklmlms rneeatkhle ctkqlaaafh eefvvredlm glaigthgsn
      241 iqqarkvpgv taieldedtg tfriygesae avkkargfle fvedfiqvpr nlvgkvigkn
      301 gkviqeivdk sgvvrvrieg dnenklpred gmvpfvfvgt kesignvqvl leyhiaylke
      361 veqlrmerlq ideqlrqigs rsysgrgrgr rgpnytsgyg tnselsnpse teserkdels
      421 dwslageddr etrhqrdsrr rpggrgrsvs ggrgrggprg gkssissvlk dpdsnpysll
      481 dntesdqtad tdaseshhst nrrrrsrrrr tdedavlmdg ltesdtasvn englgkrcd
//
LOCUS       NP_851411                822 aa            linear   ROD 08-OCT-2023
DEFINITION  BRCA1-associated ATM activator 1 isoform 2 [Mus musculus].
ACCESSION   NP_851411
VERSION     NP_851411.1
DBSOURCE    REFSEQ: accession NM_181066.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 822)
  AUTHORS   Low LH, Chow YL, Li Y, Goh CP, Putz U, Silke J, Ouchi T, Howitt J
            and Tan SS.
  TITLE     Nedd4 family interacting protein 1 (Ndfip1) is required for
            ubiquitination and nuclear trafficking of BRCA1-associated ATM
            activator 1 (BRAT1) during the DNA damage response
  JOURNAL   J Biol Chem 290 (11), 7141-7150 (2015)
   PUBMED   25631046
  REMARK    GeneRIF: Ndfip1 is required during stress for ubiquitinating and
            trafficking BRAT1 into the nucleus.
REFERENCE   2  (residues 1 to 822)
  AUTHORS   So EY and Ouchi T.
  TITLE     The Potential Role of BRCA1-Associated ATM Activator-1 (BRAT1) in
            Regulation of mTOR
  JOURNAL   J Cancer Biol Res 1 (1) (2013)
   PUBMED   25657994
REFERENCE   3  (residues 1 to 822)
  AUTHORS   So EY and Ouchi T.
  TITLE     Functional interaction of BRCA1/ATM-associated BAAT1 with the
            DNA-PK catalytic subunit
  JOURNAL   Exp Ther Med 2 (3), 443-447 (2011)
   PUBMED   22977523
REFERENCE   4  (residues 1 to 822)
  AUTHORS   Ouchi M and Ouchi T.
  TITLE     Regulation of ATM/DNA-PKcs Phosphorylation by BRCA1-Associated
            BAAT1
  JOURNAL   Genes Cancer 1 (12), 1211-1214 (2010)
   PUBMED   21779444
REFERENCE   5  (residues 1 to 822)
  AUTHORS   Carninci P, Waki K, Shiraki T, Konno H, Shibata K, Itoh M, Aizawa
            K, Arakawa T, Ishii Y, Sasaki D, Bono H, Kondo S, Sugahara Y, Saito
            R, Osato N, Fukuda S, Sato K, Watahiki A, Hirozane-Kishikawa T,
            Nakamura M, Shibata Y, Yasunishi A, Kikuchi N, Yoshiki A, Kusakabe
            M, Gustincich S, Beisel K, Pavan W, Aidinis V, Nakagawara A, Held
            WA, Iwata H, Kono T, Nakauchi H, Lyons P, Wells C, Hume DA,
            Fagiolini M, Hensch TK, Brinkmeier M, Camper S, Hirota J, Mombaerts
            P, Muramatsu M, Okazaki Y, Kawai J and Hayashizaki Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC110253.10.
            
            Summary: A similar gene in human encodes a Breast Cancer 1 (BRCA1)
            interacting protein that is involved in cell cycle checkpoint
            signaling. The similar human protein is localized to DNA double
            strand breaks caused by ionizing radiation, and regulates cellular
            DNA damage response through interactions with Ataxia Telangiectasia
            Mutated (ATM) and DNA-dependent Protein Kinase. A pseudogene of
            this gene is located on chromosome 3. Alternative splicing results
            in multiple transcript variants. [provided by RefSeq, Jan 2013].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            initiates translation at a downstream start codon, compared to
            variant 3. The encoded isoform (2) has a shorter N-terminus,
            compared to isoform 3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript from the same
            strain was available for the full length of the gene. The extent of
            this transcript is supported by transcript alignments and
            orthologous data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK085091.1, SRR13862062.102798.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..822
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 79.25 cM"
     Protein         1..822
                     /product="BRCA1-associated ATM activator 1 isoform 2"
                     /note="BRCA1-associated protein required for ATM
                     activation protein 1"
                     /calculated_mol_wt=88955
     Region          100..200
                     /region_name="Required for interaction with NDFIP1.
                     /evidence=ECO:0000250|UniProtKB:Q6PJG6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C3R1.1)"
     Region          448..481
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          495..531
                     /region_name="HEAT 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C3R1.1)"
     Region          501..530
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          540..575
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          544..576
                     /region_name="HEAT 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C3R1.1)"
     Region          592..619
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          630..657
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Site            743
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8C3R1.1)"
     CDS             1..822
                     /gene="Brat1"
                     /gene_synonym="Baat1"
                     /coded_by="NM_181066.4:71..2539"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS19823.1"
                     /db_xref="GeneID:231841"
                     /db_xref="MGI:MGI:1891679"
ORIGIN      
        1 mdpecsrllp alcavladpr qlvaddtcle klldwfktvt eaesslqllq dhpclmells
       61 hvlkpqdvsp rvlsfalrlv gvfaaqedcf eylqqgelll glfgesgapg waawsipsvr
      121 sgwiqglcyl ahhpsalhfl adsgavdtlf slqgdpslfv asaasqllvh ilalsmqgga
      181 pgspvpeaaa wpmcaqkivn hvdeslhaka tpqvtqalnv ltttfgrchn pwtgvlwerl
      241 sppvarlfer dpipavhalm dlllsvarsp vlnfaacglw emlaqtlsrl spiqagplal
      301 gtlklqhcpq elrtqafgvl lqplacilka ttqapgppgl ldgtvgsllt vdillasksa
      361 cvgllcqtla hleelqmlpq cpspwpqvhl lqaaltilhl cdgsadpsss aggrlcgtlg
      421 gcvrvqraal dflgtlsqgt splelvlevf avllktlesp esspmvlkka fqatlrwlqn
      481 phktpsssdl ssdallflge lfpilqkrlc spcwevrdsa leflthlirh wggqadfrea
      541 lrssevptla lqllqdpesy vrasavgaag qlssqglqaa paspensqaq qgllmdlmhi
      601 lstdsegfpr ravlrvftdw lrdghadvvr dtewfvatvl qavsrdldwe vrvqglelar
      661 vfltqalgqp slhcpytvgl prassprphp eflqtlcrlp lfefafcall dcdrpvaqka
      721 cdlllflrdk tvpcssprea gdspnsasve aalqrwrege qaqplgdldp eamlailral
      781 dleglqgrla kssdhveksp qsllqdmlat vgvleenead cy
//
LOCUS       NP_001411575             821 aa            linear   ROD 08-OCT-2023
DEFINITION  BRCA1-associated ATM activator 1 isoform 5 [Mus musculus].
ACCESSION   NP_001411575 XP_030110300
VERSION     NP_001411575.1
DBSOURCE    REFSEQ: accession NM_001424646.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 821)
  AUTHORS   Low LH, Chow YL, Li Y, Goh CP, Putz U, Silke J, Ouchi T, Howitt J
            and Tan SS.
  TITLE     Nedd4 family interacting protein 1 (Ndfip1) is required for
            ubiquitination and nuclear trafficking of BRCA1-associated ATM
            activator 1 (BRAT1) during the DNA damage response
  JOURNAL   J Biol Chem 290 (11), 7141-7150 (2015)
   PUBMED   25631046
  REMARK    GeneRIF: Ndfip1 is required during stress for ubiquitinating and
            trafficking BRAT1 into the nucleus.
REFERENCE   2  (residues 1 to 821)
  AUTHORS   So EY and Ouchi T.
  TITLE     The Potential Role of BRCA1-Associated ATM Activator-1 (BRAT1) in
            Regulation of mTOR
  JOURNAL   J Cancer Biol Res 1 (1) (2013)
   PUBMED   25657994
REFERENCE   3  (residues 1 to 821)
  AUTHORS   So EY and Ouchi T.
  TITLE     Functional interaction of BRCA1/ATM-associated BAAT1 with the
            DNA-PK catalytic subunit
  JOURNAL   Exp Ther Med 2 (3), 443-447 (2011)
   PUBMED   22977523
REFERENCE   4  (residues 1 to 821)
  AUTHORS   Ouchi M and Ouchi T.
  TITLE     Regulation of ATM/DNA-PKcs Phosphorylation by BRCA1-Associated
            BAAT1
  JOURNAL   Genes Cancer 1 (12), 1211-1214 (2010)
   PUBMED   21779444
REFERENCE   5  (residues 1 to 821)
  AUTHORS   Carninci P, Waki K, Shiraki T, Konno H, Shibata K, Itoh M, Aizawa
            K, Arakawa T, Ishii Y, Sasaki D, Bono H, Kondo S, Sugahara Y, Saito
            R, Osato N, Fukuda S, Sato K, Watahiki A, Hirozane-Kishikawa T,
            Nakamura M, Shibata Y, Yasunishi A, Kikuchi N, Yoshiki A, Kusakabe
            M, Gustincich S, Beisel K, Pavan W, Aidinis V, Nakagawara A, Held
            WA, Iwata H, Kono T, Nakauchi H, Lyons P, Wells C, Hume DA,
            Fagiolini M, Hensch TK, Brinkmeier M, Camper S, Hirota J, Mombaerts
            P, Muramatsu M, Okazaki Y, Kawai J and Hayashizaki Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC110253.10.
            
            On Oct 1, 2023 this sequence version replaced XP_030110300.1.
            
            Summary: A similar gene in human encodes a Breast Cancer 1 (BRCA1)
            interacting protein that is involved in cell cycle checkpoint
            signaling. The similar human protein is localized to DNA double
            strand breaks caused by ionizing radiation, and regulates cellular
            DNA damage response through interactions with Ataxia Telangiectasia
            Mutated (ATM) and DNA-dependent Protein Kinase. A pseudogene of
            this gene is located on chromosome 3. Alternative splicing results
            in multiple transcript variants. [provided by RefSeq, Jan 2013].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422600.1022936.1,
                                           SRR13948564.444882.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..821
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 79.25 cM"
     Protein         1..821
                     /product="BRCA1-associated ATM activator 1 isoform 5"
                     /note="BRCA1-associated protein required for ATM
                     activation protein 1"
                     /calculated_mol_wt=88827
     Region          99..199
                     /region_name="Required for interaction with NDFIP1.
                     /evidence=ECO:0000250|UniProtKB:Q6PJG6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C3R1.1)"
     Region          494..530
                     /region_name="HEAT 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C3R1.1)"
     Region          543..575
                     /region_name="HEAT 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C3R1.1)"
     Site            742
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8C3R1.1)"
     CDS             1..821
                     /gene="Brat1"
                     /gene_synonym="Baat1"
                     /coded_by="NM_001424646.1:71..2536"
                     /note="isoform 5 is encoded by transcript variant 7"
                     /db_xref="GeneID:231841"
                     /db_xref="MGI:MGI:1891679"
ORIGIN      
        1 mdpecsrllp alcavladpr qlvaddtcle klldwfktvt eaesslqllq dhpclmells
       61 hvlkpqdvsp rvlsfalrlv gvfaaqedcf eylqgelllg lfgesgapgw aawsipsvrs
      121 gwiqglcyla hhpsalhfla dsgavdtlfs lqgdpslfva saasqllvhi lalsmqggap
      181 gspvpeaaaw pmcaqkivnh vdeslhakat pqvtqalnvl tttfgrchnp wtgvlwerls
      241 ppvarlferd pipavhalmd lllsvarspv lnfaacglwe mlaqtlsrls piqagplalg
      301 tlklqhcpqe lrtqafgvll qplacilkat tqapgppgll dgtvgslltv dillasksac
      361 vgllcqtlah leelqmlpqc pspwpqvhll qaaltilhlc dgsadpsssa ggrlcgtlgg
      421 cvrvqraald flgtlsqgts plelvlevfa vllktlespe sspmvlkkaf qatlrwlqnp
      481 hktpsssdls sdallflgel fpilqkrlcs pcwevrdsal eflthlirhw ggqadfreal
      541 rssevptlal qllqdpesyv rasavgaagq lssqglqaap aspensqaqq gllmdlmhil
      601 stdsegfprr avlrvftdwl rdghadvvrd tewfvatvlq avsrdldwev rvqglelarv
      661 fltqalgqps lhcpytvglp rassprphpe flqtlcrlpl fefafcalld cdrpvaqkac
      721 dlllflrdkt vpcsspreag dspnsasvea alqrwregeq aqplgdldpe amlailrald
      781 leglqgrlak ssdhvekspq sllqdmlatv gvleeneadc y
//
LOCUS       NP_001411574             544 aa            linear   ROD 08-OCT-2023
DEFINITION  BRCA1-associated ATM activator 1 isoform 4 [Mus musculus].
ACCESSION   NP_001411574
VERSION     NP_001411574.1
DBSOURCE    REFSEQ: accession NM_001424645.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 544)
  AUTHORS   Low LH, Chow YL, Li Y, Goh CP, Putz U, Silke J, Ouchi T, Howitt J
            and Tan SS.
  TITLE     Nedd4 family interacting protein 1 (Ndfip1) is required for
            ubiquitination and nuclear trafficking of BRCA1-associated ATM
            activator 1 (BRAT1) during the DNA damage response
  JOURNAL   J Biol Chem 290 (11), 7141-7150 (2015)
   PUBMED   25631046
  REMARK    GeneRIF: Ndfip1 is required during stress for ubiquitinating and
            trafficking BRAT1 into the nucleus.
REFERENCE   2  (residues 1 to 544)
  AUTHORS   So EY and Ouchi T.
  TITLE     The Potential Role of BRCA1-Associated ATM Activator-1 (BRAT1) in
            Regulation of mTOR
  JOURNAL   J Cancer Biol Res 1 (1) (2013)
   PUBMED   25657994
REFERENCE   3  (residues 1 to 544)
  AUTHORS   So EY and Ouchi T.
  TITLE     Functional interaction of BRCA1/ATM-associated BAAT1 with the
            DNA-PK catalytic subunit
  JOURNAL   Exp Ther Med 2 (3), 443-447 (2011)
   PUBMED   22977523
REFERENCE   4  (residues 1 to 544)
  AUTHORS   Ouchi M and Ouchi T.
  TITLE     Regulation of ATM/DNA-PKcs Phosphorylation by BRCA1-Associated
            BAAT1
  JOURNAL   Genes Cancer 1 (12), 1211-1214 (2010)
   PUBMED   21779444
REFERENCE   5  (residues 1 to 544)
  AUTHORS   Carninci P, Waki K, Shiraki T, Konno H, Shibata K, Itoh M, Aizawa
            K, Arakawa T, Ishii Y, Sasaki D, Bono H, Kondo S, Sugahara Y, Saito
            R, Osato N, Fukuda S, Sato K, Watahiki A, Hirozane-Kishikawa T,
            Nakamura M, Shibata Y, Yasunishi A, Kikuchi N, Yoshiki A, Kusakabe
            M, Gustincich S, Beisel K, Pavan W, Aidinis V, Nakagawara A, Held
            WA, Iwata H, Kono T, Nakauchi H, Lyons P, Wells C, Hume DA,
            Fagiolini M, Hensch TK, Brinkmeier M, Camper S, Hirota J, Mombaerts
            P, Muramatsu M, Okazaki Y, Kawai J and Hayashizaki Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC110253.10.
            
            Summary: A similar gene in human encodes a Breast Cancer 1 (BRCA1)
            interacting protein that is involved in cell cycle checkpoint
            signaling. The similar human protein is localized to DNA double
            strand breaks caused by ionizing radiation, and regulates cellular
            DNA damage response through interactions with Ataxia Telangiectasia
            Mutated (ATM) and DNA-dependent Protein Kinase. A pseudogene of
            this gene is located on chromosome 3. Alternative splicing results
            in multiple transcript variants. [provided by RefSeq, Jan 2013].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13948564.1050097.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..544
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 79.25 cM"
     Protein         1..544
                     /product="BRCA1-associated ATM activator 1 isoform 4"
                     /note="BRCA1-associated protein required for ATM
                     activation protein 1"
                     /calculated_mol_wt=58463
     Region          100..200
                     /region_name="Required for interaction with NDFIP1.
                     /evidence=ECO:0000250|UniProtKB:Q6PJG6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C3R1.1)"
     Region          495..531
                     /region_name="HEAT 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C3R1.1)"
     CDS             1..544
                     /gene="Brat1"
                     /gene_synonym="Baat1"
                     /coded_by="NM_001424645.1:71..1705"
                     /note="isoform 4 is encoded by transcript variant 6"
                     /db_xref="GeneID:231841"
                     /db_xref="MGI:MGI:1891679"
ORIGIN      
        1 mdpecsrllp alcavladpr qlvaddtcle klldwfktvt eaesslqllq dhpclmells
       61 hvlkpqdvsp rvlsfalrlv gvfaaqedcf eylqqgelll glfgesgapg waawsipsvr
      121 sgwiqglcyl ahhpsalhfl adsgavdtlf slqgdpslfv asaasqllvh ilalsmqgga
      181 pgspvpeaaa wpmcaqkivn hvdeslhaka tpqvtqalnv ltttfgrchn pwtgvlwerl
      241 sppvarlfer dpipavhalm dlllsvarsp vlnfaacglw emlaqtlsrl spiqagplal
      301 gtlklqhcpq elrtqafgvl lqplacilka ttqapgppgl ldgtvgsllt vdillasksa
      361 cvgllcqtla hleelqmlpq cpspwpqvhl lqaaltilhl cdgsadpsss aggrlcgtlg
      421 gcvrvqraal dflgtlsqgt splelvlevf avllktlesp esspmvlkka fqatlrwlqn
      481 phktpsssdl ssdallflge lfpilqkrlc spcwevrdsa leflthlirh wggpthgpya
      541 ypvh
//
LOCUS       NP_001411577             830 aa            linear   ROD 08-OCT-2023
DEFINITION  BRCA1-associated ATM activator 1 isoform 7 [Mus musculus].
ACCESSION   NP_001411577 XP_006504739
VERSION     NP_001411577.1
DBSOURCE    REFSEQ: accession NM_001424648.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 830)
  AUTHORS   Low LH, Chow YL, Li Y, Goh CP, Putz U, Silke J, Ouchi T, Howitt J
            and Tan SS.
  TITLE     Nedd4 family interacting protein 1 (Ndfip1) is required for
            ubiquitination and nuclear trafficking of BRCA1-associated ATM
            activator 1 (BRAT1) during the DNA damage response
  JOURNAL   J Biol Chem 290 (11), 7141-7150 (2015)
   PUBMED   25631046
  REMARK    GeneRIF: Ndfip1 is required during stress for ubiquitinating and
            trafficking BRAT1 into the nucleus.
REFERENCE   2  (residues 1 to 830)
  AUTHORS   So EY and Ouchi T.
  TITLE     The Potential Role of BRCA1-Associated ATM Activator-1 (BRAT1) in
            Regulation of mTOR
  JOURNAL   J Cancer Biol Res 1 (1) (2013)
   PUBMED   25657994
REFERENCE   3  (residues 1 to 830)
  AUTHORS   So EY and Ouchi T.
  TITLE     Functional interaction of BRCA1/ATM-associated BAAT1 with the
            DNA-PK catalytic subunit
  JOURNAL   Exp Ther Med 2 (3), 443-447 (2011)
   PUBMED   22977523
REFERENCE   4  (residues 1 to 830)
  AUTHORS   Ouchi M and Ouchi T.
  TITLE     Regulation of ATM/DNA-PKcs Phosphorylation by BRCA1-Associated
            BAAT1
  JOURNAL   Genes Cancer 1 (12), 1211-1214 (2010)
   PUBMED   21779444
REFERENCE   5  (residues 1 to 830)
  AUTHORS   Carninci P, Waki K, Shiraki T, Konno H, Shibata K, Itoh M, Aizawa
            K, Arakawa T, Ishii Y, Sasaki D, Bono H, Kondo S, Sugahara Y, Saito
            R, Osato N, Fukuda S, Sato K, Watahiki A, Hirozane-Kishikawa T,
            Nakamura M, Shibata Y, Yasunishi A, Kikuchi N, Yoshiki A, Kusakabe
            M, Gustincich S, Beisel K, Pavan W, Aidinis V, Nakagawara A, Held
            WA, Iwata H, Kono T, Nakauchi H, Lyons P, Wells C, Hume DA,
            Fagiolini M, Hensch TK, Brinkmeier M, Camper S, Hirota J, Mombaerts
            P, Muramatsu M, Okazaki Y, Kawai J and Hayashizaki Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC110253.10.
            
            On Oct 1, 2023 this sequence version replaced XP_006504739.1.
            
            Summary: A similar gene in human encodes a Breast Cancer 1 (BRCA1)
            interacting protein that is involved in cell cycle checkpoint
            signaling. The similar human protein is localized to DNA double
            strand breaks caused by ionizing radiation, and regulates cellular
            DNA damage response through interactions with Ataxia Telangiectasia
            Mutated (ATM) and DNA-dependent Protein Kinase. A pseudogene of
            this gene is located on chromosome 3. Alternative splicing results
            in multiple transcript variants. [provided by RefSeq, Jan 2013].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422600.10480.1,
                                           SRR17784651.110767.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..830
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 79.25 cM"
     Protein         1..830
                     /product="BRCA1-associated ATM activator 1 isoform 7"
                     /note="BRCA1-associated protein required for ATM
                     activation protein 1"
                     /calculated_mol_wt=89576
     Region          100..200
                     /region_name="Required for interaction with NDFIP1.
                     /evidence=ECO:0000250|UniProtKB:Q6PJG6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C3R1.1)"
     Region          503..539
                     /region_name="HEAT 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C3R1.1)"
     Region          552..584
                     /region_name="HEAT 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C3R1.1)"
     Site            751
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8C3R1.1)"
     CDS             1..830
                     /gene="Brat1"
                     /gene_synonym="Baat1"
                     /coded_by="NM_001424648.1:71..2563"
                     /note="isoform 7 is encoded by transcript variant 9"
                     /db_xref="GeneID:231841"
                     /db_xref="MGI:MGI:1891679"
ORIGIN      
        1 mdpecsrllp alcavladpr qlvaddtcle klldwfktvt eaesslqllq dhpclmells
       61 hvlkpqdvsp rvlsfalrlv gvfaaqedcf eylqqgelll glfgesgapg waawsipsvr
      121 sgwiqglcyl ahhpsalhfl adsgavdtlf slqgdpslfv asaasqllvh ilalsmqgga
      181 pgspvpeaaa wpmcaqkivn hvdeslhaka tpqvtqalnv ltttfgrchn pwtgvlwerl
      241 sppvarlfer dpipavhalm dlllsvarsg gcgdsgspvl nfaacglwem laqtlsrlsp
      301 iqagplalgt lklqhcpqel rtqafgvllq placilkatt qapgppglld gtvgslltvd
      361 illasksacv gllcqtlahl eelqmlpqcp spwpqvhllq aaltilhlcd gsadpsssag
      421 grlcgtlggc vrvqraaldf lgtlsqgtsp lelvlevfav llktlespes spmvlkkafq
      481 atlrwlqnph ktpsssdlss dallflgelf pilqkrlcsp cwevrdsale flthlirhwg
      541 gqadfrealr ssevptlalq llqdpesyvr asavgaagql ssqglqaapa spensqaqqg
      601 llmdlmhils tdsegfprra vlrvftdwlr dghadvvrdt ewfvatvlqa vsrdldwevr
      661 vqglelarvf ltqalgqpsl hcpytvglpr assprphpef lqtlcrlplf efafcalldc
      721 drpvaqkacd lllflrdktv pcsspreagd spnsasveaa lqrwregeqa qplgdldpea
      781 mlailraldl eglqgrlaks sdhvekspqs llqdmlatvg vleeneadcy
//
LOCUS       NP_001411573             822 aa            linear   ROD 08-OCT-2023
DEFINITION  BRCA1-associated ATM activator 1 isoform 2 [Mus musculus].
ACCESSION   NP_001411573
VERSION     NP_001411573.1
DBSOURCE    REFSEQ: accession NM_001424644.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 822)
  AUTHORS   Low LH, Chow YL, Li Y, Goh CP, Putz U, Silke J, Ouchi T, Howitt J
            and Tan SS.
  TITLE     Nedd4 family interacting protein 1 (Ndfip1) is required for
            ubiquitination and nuclear trafficking of BRCA1-associated ATM
            activator 1 (BRAT1) during the DNA damage response
  JOURNAL   J Biol Chem 290 (11), 7141-7150 (2015)
   PUBMED   25631046
  REMARK    GeneRIF: Ndfip1 is required during stress for ubiquitinating and
            trafficking BRAT1 into the nucleus.
REFERENCE   2  (residues 1 to 822)
  AUTHORS   So EY and Ouchi T.
  TITLE     The Potential Role of BRCA1-Associated ATM Activator-1 (BRAT1) in
            Regulation of mTOR
  JOURNAL   J Cancer Biol Res 1 (1) (2013)
   PUBMED   25657994
REFERENCE   3  (residues 1 to 822)
  AUTHORS   So EY and Ouchi T.
  TITLE     Functional interaction of BRCA1/ATM-associated BAAT1 with the
            DNA-PK catalytic subunit
  JOURNAL   Exp Ther Med 2 (3), 443-447 (2011)
   PUBMED   22977523
REFERENCE   4  (residues 1 to 822)
  AUTHORS   Ouchi M and Ouchi T.
  TITLE     Regulation of ATM/DNA-PKcs Phosphorylation by BRCA1-Associated
            BAAT1
  JOURNAL   Genes Cancer 1 (12), 1211-1214 (2010)
   PUBMED   21779444
REFERENCE   5  (residues 1 to 822)
  AUTHORS   Carninci P, Waki K, Shiraki T, Konno H, Shibata K, Itoh M, Aizawa
            K, Arakawa T, Ishii Y, Sasaki D, Bono H, Kondo S, Sugahara Y, Saito
            R, Osato N, Fukuda S, Sato K, Watahiki A, Hirozane-Kishikawa T,
            Nakamura M, Shibata Y, Yasunishi A, Kikuchi N, Yoshiki A, Kusakabe
            M, Gustincich S, Beisel K, Pavan W, Aidinis V, Nakagawara A, Held
            WA, Iwata H, Kono T, Nakauchi H, Lyons P, Wells C, Hume DA,
            Fagiolini M, Hensch TK, Brinkmeier M, Camper S, Hirota J, Mombaerts
            P, Muramatsu M, Okazaki Y, Kawai J and Hayashizaki Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC110253.10.
            
            Summary: A similar gene in human encodes a Breast Cancer 1 (BRCA1)
            interacting protein that is involved in cell cycle checkpoint
            signaling. The similar human protein is localized to DNA double
            strand breaks caused by ionizing radiation, and regulates cellular
            DNA damage response through interactions with Ataxia Telangiectasia
            Mutated (ATM) and DNA-dependent Protein Kinase. A pseudogene of
            this gene is located on chromosome 3. Alternative splicing results
            in multiple transcript variants. [provided by RefSeq, Jan 2013].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.171589.1,
                                           SRR1660813.112899.1 [ECO:0000332]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..822
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 79.25 cM"
     Protein         1..822
                     /product="BRCA1-associated ATM activator 1 isoform 2"
                     /note="BRCA1-associated protein required for ATM
                     activation protein 1"
                     /calculated_mol_wt=88955
     Region          100..200
                     /region_name="Required for interaction with NDFIP1.
                     /evidence=ECO:0000250|UniProtKB:Q6PJG6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C3R1.1)"
     Region          495..531
                     /region_name="HEAT 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C3R1.1)"
     Region          544..576
                     /region_name="HEAT 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C3R1.1)"
     Site            743
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8C3R1.1)"
     CDS             1..822
                     /gene="Brat1"
                     /gene_synonym="Baat1"
                     /coded_by="NM_001424644.1:531..2999"
                     /note="isoform 2 is encoded by transcript variant 5"
                     /db_xref="GeneID:231841"
                     /db_xref="MGI:MGI:1891679"
ORIGIN      
        1 mdpecsrllp alcavladpr qlvaddtcle klldwfktvt eaesslqllq dhpclmells
       61 hvlkpqdvsp rvlsfalrlv gvfaaqedcf eylqqgelll glfgesgapg waawsipsvr
      121 sgwiqglcyl ahhpsalhfl adsgavdtlf slqgdpslfv asaasqllvh ilalsmqgga
      181 pgspvpeaaa wpmcaqkivn hvdeslhaka tpqvtqalnv ltttfgrchn pwtgvlwerl
      241 sppvarlfer dpipavhalm dlllsvarsp vlnfaacglw emlaqtlsrl spiqagplal
      301 gtlklqhcpq elrtqafgvl lqplacilka ttqapgppgl ldgtvgsllt vdillasksa
      361 cvgllcqtla hleelqmlpq cpspwpqvhl lqaaltilhl cdgsadpsss aggrlcgtlg
      421 gcvrvqraal dflgtlsqgt splelvlevf avllktlesp esspmvlkka fqatlrwlqn
      481 phktpsssdl ssdallflge lfpilqkrlc spcwevrdsa leflthlirh wggqadfrea
      541 lrssevptla lqllqdpesy vrasavgaag qlssqglqaa paspensqaq qgllmdlmhi
      601 lstdsegfpr ravlrvftdw lrdghadvvr dtewfvatvl qavsrdldwe vrvqglelar
      661 vfltqalgqp slhcpytvgl prassprphp eflqtlcrlp lfefafcall dcdrpvaqka
      721 cdlllflrdk tvpcssprea gdspnsasve aalqrwrege qaqplgdldp eamlailral
      781 dleglqgrla kssdhveksp qsllqdmlat vgvleenead cy
//
LOCUS       NP_001411576             829 aa            linear   ROD 08-OCT-2023
DEFINITION  BRCA1-associated ATM activator 1 isoform 6 [Mus musculus].
ACCESSION   NP_001411576 XP_006504740
VERSION     NP_001411576.1
DBSOURCE    REFSEQ: accession NM_001424647.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 829)
  AUTHORS   Low LH, Chow YL, Li Y, Goh CP, Putz U, Silke J, Ouchi T, Howitt J
            and Tan SS.
  TITLE     Nedd4 family interacting protein 1 (Ndfip1) is required for
            ubiquitination and nuclear trafficking of BRCA1-associated ATM
            activator 1 (BRAT1) during the DNA damage response
  JOURNAL   J Biol Chem 290 (11), 7141-7150 (2015)
   PUBMED   25631046
  REMARK    GeneRIF: Ndfip1 is required during stress for ubiquitinating and
            trafficking BRAT1 into the nucleus.
REFERENCE   2  (residues 1 to 829)
  AUTHORS   So EY and Ouchi T.
  TITLE     The Potential Role of BRCA1-Associated ATM Activator-1 (BRAT1) in
            Regulation of mTOR
  JOURNAL   J Cancer Biol Res 1 (1) (2013)
   PUBMED   25657994
REFERENCE   3  (residues 1 to 829)
  AUTHORS   So EY and Ouchi T.
  TITLE     Functional interaction of BRCA1/ATM-associated BAAT1 with the
            DNA-PK catalytic subunit
  JOURNAL   Exp Ther Med 2 (3), 443-447 (2011)
   PUBMED   22977523
REFERENCE   4  (residues 1 to 829)
  AUTHORS   Ouchi M and Ouchi T.
  TITLE     Regulation of ATM/DNA-PKcs Phosphorylation by BRCA1-Associated
            BAAT1
  JOURNAL   Genes Cancer 1 (12), 1211-1214 (2010)
   PUBMED   21779444
REFERENCE   5  (residues 1 to 829)
  AUTHORS   Carninci P, Waki K, Shiraki T, Konno H, Shibata K, Itoh M, Aizawa
            K, Arakawa T, Ishii Y, Sasaki D, Bono H, Kondo S, Sugahara Y, Saito
            R, Osato N, Fukuda S, Sato K, Watahiki A, Hirozane-Kishikawa T,
            Nakamura M, Shibata Y, Yasunishi A, Kikuchi N, Yoshiki A, Kusakabe
            M, Gustincich S, Beisel K, Pavan W, Aidinis V, Nakagawara A, Held
            WA, Iwata H, Kono T, Nakauchi H, Lyons P, Wells C, Hume DA,
            Fagiolini M, Hensch TK, Brinkmeier M, Camper S, Hirota J, Mombaerts
            P, Muramatsu M, Okazaki Y, Kawai J and Hayashizaki Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC110253.10.
            
            On Oct 1, 2023 this sequence version replaced XP_006504740.1.
            
            Summary: A similar gene in human encodes a Breast Cancer 1 (BRCA1)
            interacting protein that is involved in cell cycle checkpoint
            signaling. The similar human protein is localized to DNA double
            strand breaks caused by ionizing radiation, and regulates cellular
            DNA damage response through interactions with Ataxia Telangiectasia
            Mutated (ATM) and DNA-dependent Protein Kinase. A pseudogene of
            this gene is located on chromosome 3. Alternative splicing results
            in multiple transcript variants. [provided by RefSeq, Jan 2013].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784647.173530.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..829
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 79.25 cM"
     Protein         1..829
                     /product="BRCA1-associated ATM activator 1 isoform 6"
                     /note="BRCA1-associated protein required for ATM
                     activation protein 1"
                     /calculated_mol_wt=89447
     Region          99..199
                     /region_name="Required for interaction with NDFIP1.
                     /evidence=ECO:0000250|UniProtKB:Q6PJG6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C3R1.1)"
     Region          502..538
                     /region_name="HEAT 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C3R1.1)"
     Region          551..583
                     /region_name="HEAT 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C3R1.1)"
     Site            750
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8C3R1.1)"
     CDS             1..829
                     /gene="Brat1"
                     /gene_synonym="Baat1"
                     /coded_by="NM_001424647.1:71..2560"
                     /note="isoform 6 is encoded by transcript variant 8"
                     /db_xref="GeneID:231841"
                     /db_xref="MGI:MGI:1891679"
ORIGIN      
        1 mdpecsrllp alcavladpr qlvaddtcle klldwfktvt eaesslqllq dhpclmells
       61 hvlkpqdvsp rvlsfalrlv gvfaaqedcf eylqgelllg lfgesgapgw aawsipsvrs
      121 gwiqglcyla hhpsalhfla dsgavdtlfs lqgdpslfva saasqllvhi lalsmqggap
      181 gspvpeaaaw pmcaqkivnh vdeslhakat pqvtqalnvl tttfgrchnp wtgvlwerls
      241 ppvarlferd pipavhalmd lllsvarsgg cgdsgspvln faacglweml aqtlsrlspi
      301 qagplalgtl klqhcpqelr tqafgvllqp lacilkattq apgppglldg tvgslltvdi
      361 llasksacvg llcqtlahle elqmlpqcps pwpqvhllqa altilhlcdg sadpsssagg
      421 rlcgtlggcv rvqraaldfl gtlsqgtspl elvlevfavl lktlespess pmvlkkafqa
      481 tlrwlqnphk tpsssdlssd allflgelfp ilqkrlcspc wevrdsalef lthlirhwgg
      541 qadfrealrs sevptlalql lqdpesyvra savgaagqls sqglqaapas pensqaqqgl
      601 lmdlmhilst dsegfprrav lrvftdwlrd ghadvvrdte wfvatvlqav srdldwevrv
      661 qglelarvfl tqalgqpslh cpytvglpra ssprphpefl qtlcrlplfe fafcalldcd
      721 rpvaqkacdl llflrdktvp csspreagds pnsasveaal qrwregeqaq plgdldpeam
      781 lailraldle glqgrlakss dhvekspqsl lqdmlatvgv leeneadcy
//
LOCUS       NP_001297615             384 aa            linear   ROD 09-OCT-2023
DEFINITION  mitogen-activated protein kinase 10 isoform 5 [Mus musculus].
ACCESSION   NP_001297615 XP_006535014 XP_017176379
VERSION     NP_001297615.1
DBSOURCE    REFSEQ: accession NM_001310686.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 384)
  AUTHORS   Priego M, Noriega L, Kalinin S, Hoffman LM, Feinstein DL and
            Morfini G.
  TITLE     Genetic deletion of c-Jun amino-terminal kinase 3 (JNK3) modestly
            increases disease severity in a mouse model of multiple sclerosis
  JOURNAL   J Neuroimmunol 382, 578152 (2023)
   PUBMED   37454525
  REMARK    GeneRIF: Genetic deletion of c-Jun amino-terminal kinase 3 (JNK3)
            modestly increases disease severity in a mouse model of multiple
            sclerosis.
REFERENCE   2  (residues 1 to 384)
  AUTHORS   Liu F, Deng Y, Zhao Y, Li Z, Gao J, Zhang Y, Yang X, Liu Y and Xia
            Y.
  TITLE     Time series RNA-seq analysis identifies MAPK10 as a critical gene
            in diabetes mellitus-induced atrial fibrillation in mice
  JOURNAL   J Mol Cell Cardiol 168, 70-82 (2022)
   PUBMED   35489387
  REMARK    GeneRIF: Time series RNA-seq analysis identifies MAPK10 as a
            critical gene in diabetes mellitus-induced atrial fibrillation in
            mice.
REFERENCE   3  (residues 1 to 384)
  AUTHORS   Cunningham JG, Scripter JD, Nti SA and Tucker ES.
  TITLE     Early construction of the thalamocortical axon pathway requires
            c-Jun N-terminal kinase signaling within the ventral forebrain
  JOURNAL   Dev Dyn 251 (3), 459-480 (2022)
   PUBMED   34494344
REFERENCE   4  (residues 1 to 384)
  AUTHORS   Goodwani S, Fernandez C, Acton PJ, Buggia-Prevot V, McReynolds ML,
            Ma J, Hu CH, Hamby ME, Jiang Y, Le K, Soth MJ, Jones P and Ray WJ.
  TITLE     Dual Leucine Zipper Kinase Is Constitutively Active in the Adult
            Mouse Brain and Has Both Stress-Induced and Homeostatic Functions
  JOURNAL   Int J Mol Sci 21 (14), 4849 (2020)
   PUBMED   32659913
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 384)
  AUTHORS   Loughran G, Chou MY, Ivanov IP, Jungreis I, Kellis M, Kiran AM,
            Baranov PV and Atkins JF.
  TITLE     Evidence of efficient stop codon readthrough in four mammalian
            genes
  JOURNAL   Nucleic Acids Res 42 (14), 8928-8938 (2014)
   PUBMED   25013167
REFERENCE   6  (residues 1 to 384)
  AUTHORS   Beier H and Grimm M.
  TITLE     Misreading of termination codons in eukaryotes by natural nonsense
            suppressor tRNAs
  JOURNAL   Nucleic Acids Res 29 (23), 4767-4782 (2001)
   PUBMED   11726686
  REMARK    Review article
REFERENCE   7  (residues 1 to 384)
  AUTHORS   Yang DD, Kuan CY, Whitmarsh AJ, Rincon M, Zheng TS, Davis RJ, Rakic
            P and Flavell RA.
  TITLE     Absence of excitotoxicity-induced apoptosis in the hippocampus of
            mice lacking the Jnk3 gene
  JOURNAL   Nature 389 (6653), 865-870 (1997)
   PUBMED   9349820
REFERENCE   8  (residues 1 to 384)
  AUTHORS   Casanova E, Garate C, Ovalle S, Calvo P and Chinchetru MA.
  TITLE     Identification of four splice variants of the mouse
            stress-activated protein kinase JNK/SAPK alpha-isoform
  JOURNAL   Neuroreport 7 (7), 1320-1324 (1996)
   PUBMED   8817558
REFERENCE   9  (residues 1 to 384)
  AUTHORS   Martin JH, Mohit AA and Miller CA.
  TITLE     Developmental expression in the mouse nervous system of the p493F12
            SAP kinase
  JOURNAL   Brain Res Mol Brain Res 35 (1-2), 47-57 (1996)
   PUBMED   8717339
REFERENCE   10 (residues 1 to 384)
  AUTHORS   Suzuki J, Yoshida S, Chen ZL, Momota Y, Kato K, Hirata A and
            Shiosaka S.
  TITLE     Ontogeny of neuropsin mRNA expression in the mouse brain
  JOURNAL   Neurosci Res 23 (4), 345-351 (1995)
   PUBMED   8602273
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC160244.11, AC123664.15,
            AC137121.9 and AC125252.7.
            
            On or before Jun 6, 2022 this sequence version replaced
            XP_017176379.1, XP_006535014.1.
            
            Summary: The protein encoded by this gene is a member of the MAP
            kinase family. MAP kinases act as integration points for multiple
            biochemical signals, and thus are involved in a wide variety of
            cellular processes, such as proliferation, differentiation,
            transcription regulation and development. This kinase is
            specifically expressed in a subset of neurons in the nervous system
            and is activated by threonine and tyrosine phosphorylation.
            Targeted deletion of this gene in mice suggests that it may have a
            role in stress-induced neuronal apoptosis. Alternatively spliced
            transcript variants encoding different isoforms have been found for
            this gene. A recent study provided evidence for translational
            readthrough in this gene, and expression of an additional
            C-terminally extended isoform via the use of an alternative
            in-frame translation termination codon. [provided by RefSeq, Dec
            2017].
            
            Transcript Variant: This variant (5) uses an alternate acceptor
            splice site in the 5' region and at the 3' terminal exon compared
            to variant 1. These differences result in translation initiation
            from an in-frame, downstream start codon, and an isoform (5) with a
            shorter N-terminus and a shorter and distinct C-terminus compared
            to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.1017145.1,
                                           SRR1660817.46366.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..384
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 49.61 cM"
     Protein         1..384
                     /product="mitogen-activated protein kinase 10 isoform 5"
                     /EC_number="2.7.11.24"
                     /note="JNK3 beta1 protein kinase; JNK3 beta2 protein
                     kinase; MAP kinase 10; MAP kinase p49 3F12; c-Jun
                     N-terminal kinase 3; stress-activated protein kinase JNK3;
                     SAPK/Erk/kinase 2"
                     /calculated_mol_wt=43966
     Region          25..360
                     /region_name="STKc_JNK"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     c-Jun N-terminal Kinase; cd07850"
                     /db_xref="CDD:270840"
     Site            order(32..38,40,53,55,72,86,108..114,116..117,151,153,
                     155..156,158,168..169,172,183,185..188,190,227)
                     /site_type="active"
                     /db_xref="CDD:270840"
     Site            order(32..38,40,53,55,86,108..114,158,168)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270840"
     Site            order(72,116,151,153,172,183,185..188,190,227)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270840"
     Site            order(112,118,127,130,159..163,323..324,326,329)
                     /site_type="other"
                     /note="KIM docking site [polypeptide binding]"
                     /db_xref="CDD:270840"
     Site            order(168..178,182..190)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270840"
     CDS             1..384
                     /gene="Mapk10"
                     /gene_synonym="C230008H04Rik; JNK3; JNK3B1; JNK3B2;
                     p493F12; p54bSAPK; SAPK(beta); Serk2"
                     /coded_by="NM_001310686.3:658..1812"
                     /note="isoform 5 is encoded by transcript variant 5"
                     /db_xref="GeneID:26414"
                     /db_xref="MGI:MGI:1346863"
ORIGIN      
        1 mskskvdnqf ysvevgdstf tvlkryqnlk pigsgaqgiv caaydavldr nvaikklsrp
       61 fqnqthakra yrelvlmkcv nhkniislln vftpqktlee fqdvylvmel mdanlcqviq
      121 meldhermsy llyqmlcgik hlhsagiihr dlkpsnivvk sdctlkildf glartagtsf
      181 mmtpyvvtry yrapevilgm gykenvdiws vgcimgemvr hkilfpgrdy idqwnkvieq
      241 lgtpcpefmk klqptvrnyv enrpkyaglt fpklfpdslf padsehnklk asqardllsk
      301 mlvidpakri svddalqhpy invwydpaev eapppqiydk qlderehtie ewkeliykev
      361 mnseektkng vvkgqpspsa qvqq
//
LOCUS       NP_001277655             619 aa            linear   ROD 09-OCT-2023
DEFINITION  AT-rich interactive domain-containing protein 5A isoform 5 [Mus
            musculus].
ACCESSION   NP_001277655
VERSION     NP_001277655.1
DBSOURCE    REFSEQ: accession NM_001290726.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 619)
  AUTHORS   Li X, Hua S, Fang D, Fei X, Tan Z, Zheng F, Wang W and Fang M.
  TITLE     RAGE deficiency ameliorates autoimmune hepatitis involving
            inhibition of IL-6 production via suppressing protein Arid5a in
            mice
  JOURNAL   Clin Exp Med 23 (6), 2167-2179 (2023)
   PUBMED   36454447
  REMARK    GeneRIF: RAGE deficiency ameliorates autoimmune hepatitis involving
            inhibition of IL-6 production via suppressing protein Arid5a in
            mice.
REFERENCE   2  (residues 1 to 619)
  AUTHORS   Taylor TC, Li Y, Li DD, Majumder S, McGeachy MJ, Biswas PS, Gingras
            S and Gaffen SL.
  TITLE     Arid5a Mediates an IL-17-Dependent Pathway That Drives Autoimmunity
            but Not Antifungal Host Defense
  JOURNAL   J Immunol 209 (6), 1138-1145 (2022)
   PUBMED   35940634
  REMARK    GeneRIF: Arid5a Mediates an IL-17-Dependent Pathway That Drives
            Autoimmunity but Not Antifungal Host Defense.
REFERENCE   3  (residues 1 to 619)
  AUTHORS   Catela C, Chen Y, Weng Y, Wen K and Kratsios P.
  TITLE     Control of spinal motor neuron terminal differentiation through
            sustained Hoxc8 gene activity
  JOURNAL   Elife 11, e70766 (2022)
   PUBMED   35315772
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 619)
  AUTHORS   Nyati KK, Hashimoto S, Singh SK, Tekguc M, Metwally H, Liu YC,
            Okuzaki D, Gemechu Y, Kang S and Kishimoto T.
  TITLE     The novel long noncoding RNA AU021063, induced by IL-6/Arid5a
            signaling, exacerbates breast cancer invasion and metastasis by
            stabilizing Trib3 and activating the Mek/Erk pathway
  JOURNAL   Cancer Lett 520, 295-306 (2021)
   PUBMED   34389433
  REMARK    GeneRIF: The novel long noncoding RNA AU021063, induced by
            IL-6/Arid5a signaling, exacerbates breast cancer invasion and
            metastasis by stabilizing Trib3 and activating the Mek/Erk pathway.
REFERENCE   5  (residues 1 to 619)
  AUTHORS   Chalise JP, Hashimoto S, Parajuli G, Kang S, Singh SK, Gemechu Y,
            Metwally H, Nyati KK, Dubey PK, Zaman MM, Nagahama Y, Hamza H,
            Masuda K and Kishimoto T.
  TITLE     Feedback regulation of Arid5a and Ppar-gamma2 maintains adipose
            tissue homeostasis
  JOURNAL   Proc Natl Acad Sci U S A 116 (30), 15128-15133 (2019)
   PUBMED   31289228
  REMARK    GeneRIF: Feedback regulation of Arid5a and Ppar-gamma2 maintains
            adipose tissue homeostasis.
REFERENCE   6  (residues 1 to 619)
  AUTHORS   Zaman MM, Masuda K, Nyati KK, Dubey PK, Ripley B, Wang K, Chalise
            JP, Higa M, Hanieh H and Kishimoto T.
  TITLE     Arid5a exacerbates IFN-gamma-mediated septic shock by stabilizing
            T-bet mRNA
  JOURNAL   Proc Natl Acad Sci U S A 113 (41), 11543-11548 (2016)
   PUBMED   27671645
  REMARK    GeneRIF: Arid5a deficiency resulted in decreased levels of
            IFN-gamma under Th1 cell conditions, in which T-box expressed in T
            cells (T-bet) mRNA expression was inhibited.
REFERENCE   7  (residues 1 to 619)
  AUTHORS   Masuda K, Ripley B, Nyati KK, Dubey PK, Zaman MM, Hanieh H, Higa M,
            Yamashita K, Standley DM, Mashima T, Katahira M, Okamoto T,
            Matsuura Y, Takeuchi O and Kishimoto T.
  TITLE     Arid5a regulates naive CD4+ T cell fate through selective
            stabilization of Stat3 mRNA
  JOURNAL   J Exp Med 213 (4), 605-619 (2016)
   PUBMED   27022145
  REMARK    GeneRIF: T cell-intrinsic role of Arid5a on fate decisions of naive
            CD4(+)T cells through selective stabilization of Stat3 mRNA.
REFERENCE   8  (residues 1 to 619)
  AUTHORS   Masuda K, Ripley B, Nishimura R, Mino T, Takeuchi O, Shioi G,
            Kiyonari H and Kishimoto T.
  TITLE     Arid5a controls IL-6 mRNA stability, which contributes to elevation
            of IL-6 level in vivo
  JOURNAL   Proc Natl Acad Sci U S A 110 (23), 9409-9414 (2013)
   PUBMED   23676272
  REMARK    GeneRIF: Arid5a controls IL-6 mRNA stability, which contributes to
            elevation of IL-6 level in vivo.
REFERENCE   9  (residues 1 to 619)
  AUTHORS   Amano K, Hata K, Muramatsu S, Wakabayashi M, Takigawa Y, Ono K,
            Nakanishi M, Takashima R, Kogo M, Matsuda A, Nishimura R and Yoneda
            T.
  TITLE     Arid5a cooperates with Sox9 to stimulate chondrocyte-specific
            transcription
  JOURNAL   Mol Biol Cell 22 (8), 1300-1311 (2011)
   PUBMED   21346191
  REMARK    GeneRIF: AT-rich interactive domain-containing protein 5a (Arid5a)
            cooperates with Sox9 to stimulate chondrocyte-specific
            transcription.
REFERENCE   10 (residues 1 to 619)
  AUTHORS   Wilsker D, Probst L, Wain HM, Maltais L, Tucker PW and Moran E.
  TITLE     Nomenclature of the ARID family of DNA-binding proteins
  JOURNAL   Genomics 86 (2), 242-251 (2005)
   PUBMED   15922553
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY196834.1, AK150170.1, AC132456.5, AK149839.1 and AK029237.1.
            
            Transcript Variant: This variant (5) contains an alternate 5' exon
            and initiates translation from an alternate start codon, compared
            to variant 1. The encoded protein (isoform 5) has a longer and
            distinct N-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK150170.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..619
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 15.2 cM"
     Protein         1..619
                     /product="AT-rich interactive domain-containing protein 5A
                     isoform 5"
                     /note="AT rich interactive domain 5A (Mrf1 like);
                     modulator recognition factor I; AT-rich interactive
                     domain-containing protein 5A; ARID domain-containing
                     protein 5A; AT rich interactive domain 5A (MRF1-like)"
                     /calculated_mol_wt=67033
     Region          85..167
                     /region_name="ARID_ARID5A"
                     /note="ARID/BRIGHT DNA binding domain of AT-rich
                     interactive domain-containing protein 5A (ARID5A) and
                     similar proteins; cd16884"
                     /db_xref="CDD:350648"
     Site            order(102..108,133,135..136,139,150,152..154,156)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:350648"
     CDS             1..619
                     /gene="Arid5a"
                     /gene_synonym="D430024K22Rik; Mrf1"
                     /coded_by="NM_001290726.1:109..1968"
                     /note="isoform 5 is encoded by transcript variant 5"
                     /db_xref="CCDS:CCDS78560.1"
                     /db_xref="GeneID:214855"
                     /db_xref="MGI:MGI:2443039"
ORIGIN      
        1 mlkggrpdlc vvnslielqk lklhvdaehq tappakgnte qseegdlpql pvspkpddeq
       61 srsqsptqlq dspeaggeqe eeqaflvsly kfmkerhtpi ervphlgfkq inlwkiykav
      121 eklgayelvt grrlwknvyd elggspgsts aatctrrhye rlvlpyvrhl kgeddkplpp
      181 tkprkqykma kelrgddgtt eklkkakdse errveqttpg ktksdatgqt qlpcqgssrd
      241 steqlgpvsg psppltgass cpeaykrlls sfyckgahgi msplakkkll aqvskaealq
      301 cqeegcrhga rspnkdiqds pqnlrgpaen sehqltpreg lqapggstrm eaqvgpcpta
      361 pmfsgcfhay ptevlkpvsq hprdffsglk drvllgppgk eegpttkesh lvwggdanhp
      421 safhkgstrk rsfypkpkac wvspmakvpt erpgapsphp sspglgskrg leeegfahgg
      481 kklravspfl kevdsketgg kpaapglavs cllgptpgpt ppeayrgtml rcplnftgsa
      541 dplkgqaslp fsplvipafp ahllattgss pmaaslmhfp ptpydavlrn rlgpassawh
      601 mppvttyaap hffhlntkl
//
LOCUS       NP_001351353             522 aa            linear   ROD 09-OCT-2023
DEFINITION  pro-neuregulin-1, membrane-bound isoform isoform 5 [Mus musculus].
ACCESSION   NP_001351353 XP_017168126
VERSION     NP_001351353.1
DBSOURCE    REFSEQ: accession NM_001364424.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 522)
  AUTHORS   Mikami Y, Iwase F, Ohshima D, Tomida T and Adachi-Akahane S.
  TITLE     Compensatory role of neuregulin-1 in diabetic cardiomyopathy
  JOURNAL   J Pharmacol Sci 153 (3), 130-141 (2023)
   PUBMED   37770154
  REMARK    GeneRIF: Compensatory role of neuregulin-1 in diabetic
            cardiomyopathy.
REFERENCE   2  (residues 1 to 522)
  AUTHORS   Qiao XY, Wang Y, Zhang W, Li Q, Liu C, Dao JJ, Qiao CM, Cui C, Shen
            YQ and Zhao WJ.
  TITLE     Involvement of CXCL10 in Neuronal Damage under the Condition of
            Spinal Cord Injury and the Potential Therapeutic Effect of Nrg1
  JOURNAL   J Integr Neurosci 22 (4), 96 (2023)
   PUBMED   37519170
  REMARK    GeneRIF: Involvement of CXCL10 in Neuronal Damage under the
            Condition of Spinal Cord Injury and the Potential Therapeutic
            Effect of Nrg1.
REFERENCE   3  (residues 1 to 522)
  AUTHORS   Liu H, Lu P, He S, Luo Y, Fang Y, Benkaci S, Wu B, Wang Y and Zhou
            B.
  TITLE     beta-Catenin regulates endocardial cushion growth by suppressing
            p21
  JOURNAL   Life Sci Alliance 6 (9), e202302163 (2023)
   PUBMED   37385754
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 522)
  AUTHORS   Kong L, Hassinan CW, Gerstner F, Buettner JM, Petigrow JB, Valdivia
            DO, Chan-Cortes MH, Mistri A, Cao A, McGaugh SA, Denton M, Brown S,
            Ross J, Schwab MH, Simon CM and Sumner CJ.
  TITLE     Boosting neuregulin 1 type-III expression hastens SMA motor axon
            maturation
  JOURNAL   Acta Neuropathol Commun 11 (1), 53 (2023)
   PUBMED   36997967
  REMARK    GeneRIF: Boosting neuregulin 1 type-III expression hastens SMA
            motor axon maturation.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 522)
  AUTHORS   Zhang X, Xiao G, Johnson C, Cai Y, Horowitz ZK, Mennicke C, Coffey
            R, Haider M, Threadgill D, Eliscu R, Oldham MC, Greenbaum A and
            Ghashghaei HT.
  TITLE     Bulk and mosaic deletions of Egfr reveal regionally defined
            gliogenesis in the developing mouse forebrain
  JOURNAL   iScience 26 (3), 106242 (2023)
   PUBMED   36915679
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 522)
  AUTHORS   Gassmann M, Casagranda F, Orioli D, Simon H, Lai C, Klein R and
            Lemke G.
  TITLE     Aberrant neural and cardiac development in mice lacking the ErbB4
            neuregulin receptor
  JOURNAL   Nature 378 (6555), 390-394 (1995)
   PUBMED   7477376
REFERENCE   7  (residues 1 to 522)
  AUTHORS   Meyer,D. and Birchmeier,C.
  TITLE     Multiple essential functions of neuregulin in development
  JOURNAL   Nature 378 (6555), 386-390 (1995)
   PUBMED   7477375
  REMARK    Erratum:[Nature 1995 Dec 14;378(6558):753]
REFERENCE   8  (residues 1 to 522)
  AUTHORS   Moscoso LM, Chu GC, Gautam M, Noakes PG, Merlie JP and Sanes JR.
  TITLE     Synapse-associated expression of an acetylcholine receptor-inducing
            protein, ARIA/heregulin, and its putative receptors, ErbB2 and
            ErbB3, in developing mammalian muscle
  JOURNAL   Dev Biol 172 (1), 158-169 (1995)
   PUBMED   7589796
REFERENCE   9  (residues 1 to 522)
  AUTHORS   Yang Y, Spitzer E, Meyer D, Sachs M, Niemann C, Hartmann G, Weidner
            KM, Birchmeier C and Birchmeier W.
  TITLE     Sequential requirement of hepatocyte growth factor and neuregulin
            in the morphogenesis and differentiation of the mammary gland
  JOURNAL   J Cell Biol 131 (1), 215-226 (1995)
   PUBMED   7559778
REFERENCE   10 (residues 1 to 522)
  AUTHORS   Ho WH, Armanini MP, Nuijens A, Phillips HS and Osheroff PL.
  TITLE     Sensory and motor neuron-derived factor. A novel heregulin variant
            highly expressed in sensory and motor neurons
  JOURNAL   J Biol Chem 270 (24), 14523-14532 (1995)
   PUBMED   7782315
  REMARK    Erratum:[J Biol Chem. 1995 Nov 3;270(44):26722. PMID: 7592900]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132407.3 and AC127374.4.
            
            On Jun 16, 2018 this sequence version replaced XP_017168126.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR6116558.92618.1,
                                           SRR1660815.141289.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..522
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 18.75 cM"
     Protein         1..522
                     /product="pro-neuregulin-1, membrane-bound isoform isoform
                     5"
                     /note="heregulin; type III neuregulin 1; type I neuregulin
                     1; pro-neuregulin-1, membrane-bound isoform"
                     /calculated_mol_wt=56834
     Region          327..>484
                     /region_name="Neuregulin"
                     /note="Neuregulin family; pfam02158"
                     /db_xref="CDD:426627"
     CDS             1..522
                     /gene="Nrg1"
                     /gene_synonym="6030402G23Rik; ARIA; D230005F13Rik; GGF;
                     GGFII; Hgl; HRG; HRGalpha; NDF; Pro-NRG1; SMDF"
                     /coded_by="NM_001364424.1:641..2209"
                     /note="isoform 5 is encoded by transcript variant 5"
                     /db_xref="GeneID:211323"
                     /db_xref="MGI:MGI:96083"
ORIGIN      
        1 meiyppdmse gaggrsssps tqlsadpsld glpaaehmpd thtedgrspg llglavpccv
       61 cleaerlrgc lnsekicivp ilaclvslcl ciaglkwvfv dkifeydspt hldpgglgqd
      121 pvisldptaa savlvsseay tspvskaqse aeahvtgqgd hvavasepsa vptrknrlsa
      181 fpplhstppp fpspartpev rtpksgtqpq ttetnlqtap klstststtg tshlikcaek
      241 ektfcvngge cfmvkdlsnp srylckcpne ftgdrcqnyv masfykhlgi efmeaeelyq
      301 krvltitgic iallvvgimc vvaycktkkq rqklhdrlrq slrsernnmv niangphhpn
      361 pppenvqlvn qyvsknviss ehiverevet sfstshytst ahhsttvtqt pshswsnght
      421 esiiseshsv immssvensr hsspaggprg rlhglggpre cnsflrhare tpdsyrdsph
      481 serhnliael rrnkayrskc mqielsathl rsssiphlgf il
//
LOCUS       NP_001281072            1169 aa            linear   ROD 09-OCT-2023
DEFINITION  homeodomain-interacting protein kinase 2 isoform 3 [Mus musculus].
ACCESSION   NP_001281072 XP_006505667
VERSION     NP_001281072.1
DBSOURCE    REFSEQ: accession NM_001294143.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1169)
  AUTHORS   Wang G, Ma Z, Song C, Wang X and Zhou Z.
  TITLE     miR-147b is an oncomiR acting synergistically with HIPK2 to promote
            pancreatic carcinogenesis
  JOURNAL   Cell Signal 111, 110840 (2023)
   PUBMED   37543099
  REMARK    GeneRIF: miR-147b is an oncomiR acting synergistically with HIPK2
            to promote pancreatic carcinogenesis.
REFERENCE   2  (residues 1 to 1169)
  AUTHORS   Zhong W, Hong C, Dong Y, Li Y, Xiao C and Liu X.
  TITLE     ASH2L Aggravates Fibrosis and Inflammation through HIPK2 in High
            Glucose-Induced Glomerular Mesangial Cells
  JOURNAL   Genes (Basel) 13 (12), 2244 (2022)
   PUBMED   36553510
  REMARK    GeneRIF: ASH2L Aggravates Fibrosis and Inflammation through HIPK2
            in High Glucose-Induced Glomerular Mesangial Cells.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1169)
  AUTHORS   Zhou Q, Meng D, Li F, Zhang X, Liu L, Zhu Y, Liu S, Xu M, Deng J,
            Lei Z, Sluijter JPG and Xiao J.
  TITLE     Inhibition of HIPK2 protects stress-induced pathological cardiac
            remodeling
  JOURNAL   EBioMedicine 85, 104274 (2022)
   PUBMED   36182775
  REMARK    GeneRIF: Inhibition of HIPK2 protects stress-induced pathological
            cardiac remodeling.
REFERENCE   4  (residues 1 to 1169)
  AUTHORS   Cheung KL, Jaganathan A, Hu Y, Xu F, Lejeune A, Sharma R, Caescu
            CI, Meslamani J, Vincek A, Zhang F, Lee K, Zaware N, Qayum AA, Ren
            C, Kaplan MH, He JC, Xiong H and Zhou MM.
  TITLE     HIPK2 directs cell type-specific regulation of STAT3
            transcriptional activity in Th17 cell differentiation
  JOURNAL   Proc Natl Acad Sci U S A 119 (14), e2117112119 (2022)
   PUBMED   35344430
  REMARK    GeneRIF: HIPK2 directs cell type-specific regulation of STAT3
            transcriptional activity in Th17 cell differentiation.
REFERENCE   5  (residues 1 to 1169)
  AUTHORS   Yu Q, Liu L, Zhang X, Chang H, Ma S, Xie Z, Tang S, Ju X, Zhu H,
            Shen B and Zhang Q.
  TITLE     MiR-221-3p targets HIPK2 to promote diabetic wound healing
  JOURNAL   Microvasc Res 140, 104306 (2022)
   PUBMED   34973299
  REMARK    GeneRIF: MiR-221-3p targets HIPK2 to promote diabetic wound
            healing.
REFERENCE   6  (residues 1 to 1169)
  AUTHORS   Hofmann TG, Mincheva A, Lichter P, Droge W and Schmitz ML.
  TITLE     Human homeodomain-interacting protein kinase-2 (HIPK2) is a member
            of the DYRK family of protein kinases and maps to chromosome
            7q32-q34
  JOURNAL   Biochimie 82 (12), 1123-1127 (2000)
   PUBMED   11120354
REFERENCE   7  (residues 1 to 1169)
  AUTHORS   Wang W, Link V and Green JM.
  TITLE     Identification and cloning of a CD43-associated serine/threonine
            kinase
  JOURNAL   Cell Immunol 205 (1), 34-39 (2000)
   PUBMED   11078605
REFERENCE   8  (residues 1 to 1169)
  AUTHORS   Ebling FJ, Brooks AN, Cronin AS, Ford H and Kerr JB.
  TITLE     Estrogenic induction of spermatogenesis in the hypogonadal mouse
  JOURNAL   Endocrinology 141 (8), 2861-2869 (2000)
   PUBMED   10919273
REFERENCE   9  (residues 1 to 1169)
  AUTHORS   Kim YH, Choi CY and Kim Y.
  TITLE     Covalent modification of the homeodomain-interacting protein kinase
            2 (HIPK2) by the ubiquitin-like protein SUMO-1
  JOURNAL   Proc Natl Acad Sci U S A 96 (22), 12350-12355 (1999)
   PUBMED   10535925
REFERENCE   10 (residues 1 to 1169)
  AUTHORS   Kim YH, Choi CY, Lee SJ, Conti MA and Kim Y.
  TITLE     Homeodomain-interacting protein kinases, a novel family of
            co-repressors for homeodomain transcription factors
  JOURNAL   J Biol Chem 273 (40), 25875-25879 (1998)
   PUBMED   9748262
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154016.2, AF170301.1 and BM122543.2.
            
            On Jun 25, 2014 this sequence version replaced XP_006505667.1.
            
            Transcript Variant: This variant (3) uses an alternate in-frame
            splice site in the central coding region compared to variant 2. The
            encoded isoform (3) is shorter than isoform 2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF170301.1, BC031904.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1169
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 17.85 cM"
     Protein         1..1169
                     /product="homeodomain-interacting protein kinase 2 isoform
                     3"
                     /EC_number="2.7.11.1"
                     /note="nuclear body-associated kinase 1; sialophorin
                     tail-associated nuclear serine/threonine-protein kinase"
                     /calculated_mol_wt=127546
     Region          183..537
                     /region_name="STKc_HIPK2"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     Homeodomain-Interacting Protein Kinase 2; cd14227"
                     /db_xref="CDD:271129"
     Site            order(205..209,213,226,228,242,261,277..280,283,285..286,
                     324,326,328..329,331,346,349,359,361..364,366,403)
                     /site_type="active"
                     /db_xref="CDD:271129"
     Site            order(205..209,213,226,228,261,277..280,283,324,326,
                     328..329,331,346)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271129"
     Site            order(242,285,324,326,349,359,361..364,366,403)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:271129"
     Site            345..366
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:271129"
     CDS             1..1169
                     /gene="Hipk2"
                     /gene_synonym="1110014O20Rik; B230339E18Rik; Stank"
                     /coded_by="NM_001294143.1:374..3883"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS80527.1"
                     /db_xref="GeneID:15258"
                     /db_xref="MGI:MGI:1314872"
ORIGIN      
        1 mapvyegmas hvqvfsphtl qssafcsvkk lkvepssnwd mtgygshskv ysqsknipps
       61 qpasttvsts lpipnpslpy eqtiifpgst ghivvtsass tsvtgqvlgg phnlmrrstv
      121 slldtyqkcg lkrkseeien tssvqiieeh ppmiqnnasg atvatattst atsknsgsns
      181 egdyqlvqhe vlcsmtntye vleflgrgtf gqvvkcwkrg tneivaikil knhpsyarqg
      241 qievsilarl stesaddynf vrayecfqhk nhtclvfeml eqnlydflkq nkfsplplky
      301 irpvlqqvat almklkslgl ihadlkpeni mlvdpsrqpy rvkvidfgsa shvskavcst
      361 ylqsryyrap eiilglpfce aidmwslgcv iaelflgwpl ypgaseydqi ryisqtqglp
      421 aeyllsagtk ttrffnrdtd spyplwrlkt pddheaetgi kskearkyif nclddmaqvn
      481 mttdlegsdm lvekadrref idllkkmlti dadkrvtpie tlnhpfvtmt hlldfphsah
      541 vkscfqnmei ckrrvnmydt vnqsktpfit hvapststnl tmtfnnqltt vhnqpsaasm
      601 aavaprsmpl qtgtaqicar pdpfqqaliv cppgfqglqa spskhagysv rmenavpivt
      661 qapgaqplqi qpgllaqqaw pggaqqillp pawqqltgva thtsvqhaav ipetmagtqq
      721 ladwrnthah gshynpimqq palltghvtl paaqplnvgv ahvmrqqpts ttssrkskqh
      781 qssvrnvstc evtssqaiss pqrskrvken tpprcamvhs spacstsvtc gwgdvasstt
      841 rerqrqtivi pdtpsptvsv itissdtdee eeqkhaptst vskqrknvis cvtvhdspys
      901 dsssntspys vqqrtghngt ntldtkggle nhctgnprti ivpplktqas evlvecdslg
      961 paisashhss sfkskssstv tstsghssgs ssgaiayrqq rpgphfqqqq plnlsqaqqh
     1021 maadrtgshr rqqayitptm aqapytfphn spshgtvhph laaaahlptq phlytytapt
     1081 algstgtvah lvasqgsarh tvqhtaypas ivhqvpvsmg prvlpsptih psqypaqfah
     1141 qtyisaspas tvytgyplsp akvnqypyi
//
LOCUS       NP_001351563             483 aa            linear   ROD 09-OCT-2023
DEFINITION  RNA-binding protein Nova-1 isoform 2 [Mus musculus].
ACCESSION   NP_001351563 XP_006516213
VERSION     NP_001351563.1
DBSOURCE    REFSEQ: accession NM_001364634.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 483)
  AUTHORS   Tajima Y, Ito K, Yuan Y, Frank MO, Saito Y and Darnell RB.
  TITLE     NOVA1 acts on Impact to regulate hypothalamic function and
            translation in inhibitory neurons
  JOURNAL   Cell Rep 42 (2), 112050 (2023)
   PUBMED   36716149
  REMARK    GeneRIF: NOVA1 acts on Impact to regulate hypothalamic function and
            translation in inhibitory neurons.
REFERENCE   2  (residues 1 to 483)
  AUTHORS   Brahma MK, Xiao P, Popa M, Negueruela J, Vandenbempt V, Demine S,
            Cardozo AK and Gurzov EN.
  TITLE     Nova1 or Bim Deficiency in Pancreatic beta-Cells Does Not Alter
            Multiple Low-Dose Streptozotocin-Induced Diabetes and Diet-Induced
            Obesity in Mice
  JOURNAL   Nutrients 14 (18), 3866 (2022)
   PUBMED   36145242
  REMARK    GeneRIF: Nova1 or Bim Deficiency in Pancreatic beta-Cells Does Not
            Alter Multiple Low-Dose Streptozotocin-Induced Diabetes and
            Diet-Induced Obesity in Mice.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 483)
  AUTHORS   Krach F, Wheeler EC, Regensburger M, Boerstler T, Wend H, Vu AQ,
            Wang R, Reischl S, Boldt K, Batra R, Aigner S, Ravits J, Winkler J,
            Yeo GW and Winner B.
  TITLE     Aberrant NOVA1 function disrupts alternative splicing in early
            stages of amyotrophic lateral sclerosis
  JOURNAL   Acta Neuropathol 144 (3), 413-435 (2022)
   PUBMED   35778567
  REMARK    GeneRIF: Aberrant NOVA1 function disrupts alternative splicing in
            early stages of amyotrophic lateral sclerosis.
REFERENCE   4  (residues 1 to 483)
  AUTHORS   Li D, Shen M, Deng X and Bai Y.
  TITLE     MicroRNA miR-27a-3p accelerates cardiac hypertrophy by targeting
            neuro-oncological ventral antigen 1
  JOURNAL   Bioengineered 13 (4), 8982-8993 (2022)
   PUBMED   35348441
  REMARK    GeneRIF: MicroRNA miR-27a-3p accelerates cardiac hypertrophy by
            targeting neuro-oncological ventral antigen 1.
REFERENCE   5  (residues 1 to 483)
  AUTHORS   Johnson V, Junge HJ and Chen Z.
  TITLE     Temporal regulation of axonal repulsion by alternative splicing of
            a conserved microexon in mammalian Robo1 and Robo2
  JOURNAL   Elife 8, e46042 (2019)
   PUBMED   31392959
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 483)
  AUTHORS   Jensen KB, Dredge BK, Stefani G, Zhong R, Buckanovich RJ, Okano HJ,
            Yang YY and Darnell RB.
  TITLE     Nova-1 regulates neuron-specific alternative splicing and is
            essential for neuronal viability
  JOURNAL   Neuron 25 (2), 359-371 (2000)
   PUBMED   10719891
REFERENCE   7  (residues 1 to 483)
  AUTHORS   Yang YY, Yin GL and Darnell RB.
  TITLE     The neuronal RNA-binding protein Nova-2 is implicated as the
            autoantigen targeted in POMA patients with dementia
  JOURNAL   Proc Natl Acad Sci U S A 95 (22), 13254-13259 (1998)
   PUBMED   9789075
REFERENCE   8  (residues 1 to 483)
  AUTHORS   Fletcher CF, Okano HJ, Gilbert DJ, Yang Y, Yang C, Copeland NG,
            Jenkins NA and Darnell RB.
  TITLE     Mouse chromosomal locations of nine genes encoding homologs of
            human paraneoplastic neurologic disorder antigens
  JOURNAL   Genomics 45 (2), 313-319 (1997)
   PUBMED   9344654
REFERENCE   9  (residues 1 to 483)
  AUTHORS   Buckanovich RJ and Darnell RB.
  TITLE     The neuronal RNA binding protein Nova-1 recognizes specific RNA
            targets in vitro and in vivo
  JOURNAL   Mol Cell Biol 17 (6), 3194-3201 (1997)
   PUBMED   9154818
REFERENCE   10 (residues 1 to 483)
  AUTHORS   Buckanovich RJ, Yang YY and Darnell RB.
  TITLE     The onconeural antigen Nova-1 is a neuron-specific RNA-binding
            protein, the activity of which is inhibited by paraneoplastic
            antibodies
  JOURNAL   J Neurosci 16 (3), 1114-1122 (1996)
   PUBMED   8558240
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156636.2, AC108802.15 and CT009504.11.
            
            On Jun 26, 2018 this sequence version replaced XP_006516213.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.26157.1,
                                           SRR1660819.28537.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..483
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 21.46 cM"
     Protein         1..483
                     /product="RNA-binding protein Nova-1 isoform 2"
                     /note="RNA-binding protein Nova-1; ventral neuron-specific
                     protein 1; neuro-oncological ventral antigen 1"
                     /calculated_mol_wt=49150
     Region          49..121
                     /region_name="KH-I_NOVA_rpt1"
                     /note="first type I K homology (KH) RNA-binding domain
                     found in the family of neuro-oncological ventral antigen
                     (Nova); cd22435"
                     /db_xref="CDD:411863"
     Site            order(61..63,65..69,72..73,83..85,87..89,98)
                     /site_type="other"
                     /note="RNA binding site [nucleotide binding]"
                     /db_xref="CDD:411863"
     Region          148..217
                     /region_name="KH-I_NOVA_rpt2"
                     /note="second type I K homology (KH) RNA-binding domain
                     found in the family of neuro-oncological ventral antigen
                     (Nova); cd22436"
                     /db_xref="CDD:411864"
     Site            order(159..161,163..167,170..171,181..183,185..187,195)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:411864"
     Region          398..468
                     /region_name="KH-I_NOVA_rpt3"
                     /note="third type I K homology (KH) RNA-binding domain
                     found in the family of neuro-oncological ventral antigen
                     (Nova); cd09031"
                     /db_xref="CDD:411807"
     Site            order(406..407,409..411,413..417,420..421,431..437,439,
                     444,446)
                     /site_type="other"
                     /note="RNA binding site [nucleotide binding]"
                     /db_xref="CDD:411807"
     CDS             1..483
                     /gene="Nova1"
                     /gene_synonym="9430099M15Rik; G630039L02; Nova-1"
                     /coded_by="NM_001364634.1:17..1468"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="GeneID:664883"
                     /db_xref="MGI:MGI:104297"
ORIGIN      
        1 mmaaapiqqn gthtgvpidl dppdsrkrpl eappeagstk rtntgedgqy flkvlipsya
       61 agsiigkggq tivqlqketg atiklskskd fypgttervc liqgtiealn avhgfiaeki
      121 rempqnvakt epvsilqpqt tvnpdrikqv kiivpnstag liigkggatv kaimeqsgaw
      181 vqlsqkpdgi nlqervvtvs gepeqnrkav eliiqkiqed pqsgsclnis yanvtgpvan
      241 snptgspyan taevlptaaa aagllghanl agvaafpavl sgftgndlva itsalntlas
      301 ygynlntlgl glsqaaatga laaaaasanp aaaaanllat yaseasasgs taggtagtfa
      361 lgslaaataa tngyfgaasp laasailgte kstdgskdvv eiavpenlvg ailgkggktl
      421 veyqeltgar iqiskkgefv pgtrnrkvti tgtpaatqaa qylitqrity eqgvraanpq
      481 kvg
//
LOCUS       NP_001344566             763 aa            linear   ROD 09-OCT-2023
DEFINITION  DNA-binding protein SATB1 isoform 3 [Mus musculus].
ACCESSION   NP_001344566 XP_006523991
VERSION     NP_001344566.1
DBSOURCE    REFSEQ: accession NM_001357637.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 763)
  AUTHORS   Naito T, Ise M, Tanaka Y, Kohwi-Shigematsu T and Kondo M.
  TITLE     Crucial Roles of SATB1 in Regulation of Thymocyte Migration after
            Positive Selection
  JOURNAL   J Immunol 211 (2), 209-218 (2023)
   PUBMED   37256264
  REMARK    GeneRIF: Crucial Roles of SATB1 in Regulation of Thymocyte
            Migration after Positive Selection.
REFERENCE   2  (residues 1 to 763)
  AUTHORS   Nomura A, Kobayashi T, Seo W, Ohno-Oishi M, Kakugawa K, Muroi S,
            Yoshida H, Endo TA, Moro K and Taniuchi I.
  TITLE     Identification of a novel enhancer essential for Satb1 expression
            in TH2 cells and activated ILC2s
  JOURNAL   Life Sci Alliance 6 (8), e202301897 (2023)
   PUBMED   37193606
  REMARK    GeneRIF: Identification of a novel enhancer essential for Satb1
            expression in TH2 cells and activated ILC2s.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 763)
  AUTHORS   Knowles SJ, Stafford AM, Zaman T, Angara K, Williams MR, Newbern JM
            and Vogt D.
  TITLE     Distinct hyperactive RAS/MAPK alleles converge on common GABAergic
            interneuron core programs
  JOURNAL   Development 150 (10) (2023)
   PUBMED   37254876
REFERENCE   4  (residues 1 to 763)
  AUTHORS   Wang B, Ji L and Bian Q.
  TITLE     SATB1 regulates 3D genome architecture in T cells by constraining
            chromatin interactions surrounding CTCF-binding sites
  JOURNAL   Cell Rep 42 (4), 112323 (2023)
   PUBMED   37000624
  REMARK    GeneRIF: SATB1 regulates 3D genome architecture in T cells by
            constraining chromatin interactions surrounding CTCF-binding sites.
REFERENCE   5  (residues 1 to 763)
  AUTHORS   Vasilopoulos N, Kaplanian A, Vinos M, Katsaiti Y, Christodoulou O,
            Denaxa M and Skaliora I.
  TITLE     The role of selective SATB1 deletion in somatostatin expressing
            interneurons on endogenous network activity and the transition to
            epilepsy
  JOURNAL   J Neurosci Res 101 (4), 424-447 (2023)
   PUBMED   36541427
  REMARK    GeneRIF: The role of selective SATB1 deletion in somatostatin
            expressing interneurons on endogenous network activity and the
            transition to epilepsy.
REFERENCE   6  (residues 1 to 763)
  AUTHORS   Seo J, Lozano MM and Dudley JP.
  TITLE     Nuclear matrix binding regulates SATB1-mediated transcriptional
            repression
  JOURNAL   J Biol Chem 280 (26), 24600-24609 (2005)
   PUBMED   15851481
  REMARK    GeneRIF: SATB1-mediated transcriptional repression is regulated by
            nuclear matrix binding
REFERENCE   7  (residues 1 to 763)
  AUTHORS   Nie H, Maika SD, Tucker PW and Gottlieb PD.
  TITLE     A role for SATB1, a nuclear matrix association region-binding
            protein, in the development of CD8SP thymocytes and peripheral T
            lymphocytes
  JOURNAL   J Immunol 174 (8), 4745-4752 (2005)
   PUBMED   15814699
  REMARK    GeneRIF: essential role for SATB1 late in the development and
            maturation of CD8SP T cells
REFERENCE   8  (residues 1 to 763)
  AUTHORS   Cai S, Han HJ and Kohwi-Shigematsu T.
  TITLE     Tissue-specific nuclear architecture and gene expression regulated
            by SATB1
  JOURNAL   Nat Genet 34 (1), 42-51 (2003)
   PUBMED   12692553
  REMARK    GeneRIF: in thymocyte nuclei, SATB1 has a cage-like 'network'
            distribution circumscribing heterochromatin and selectively tethers
            specialized DNA sequences onto its network
REFERENCE   9  (residues 1 to 763)
  AUTHORS   Alvarez JD, Yasui DH, Niida H, Joh T, Loh DY and Kohwi-Shigematsu
            T.
  TITLE     The MAR-binding protein SATB1 orchestrates temporal and spatial
            expression of multiple genes during T-cell development
  JOURNAL   Genes Dev 14 (5), 521-535 (2000)
   PUBMED   10716941
REFERENCE   10 (residues 1 to 763)
  AUTHORS   Nakagomi K, Kohwi Y, Dickinson LA and Kohwi-Shigematsu T.
  TITLE     A novel DNA-binding motif in the nuclear matrix attachment
            DNA-binding protein SATB1
  JOURNAL   Mol Cell Biol 14 (3), 1852-1860 (1994)
   PUBMED   8114718
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154796.2, AC131975.28 and AW045567.1.
            
            On Nov 4, 2017 this sequence version replaced XP_006523991.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.101744.1,
                                           SRR11927934.5132987.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..763
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 26.81 cM"
     Protein         1..763
                     /product="DNA-binding protein SATB1 isoform 3"
                     /note="DNA-binding protein Satb1"
                     /calculated_mol_wt=85621
     Region          1..56
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60611.2)"
     Region          20..40
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60611.2)"
     Region          72..170
                     /region_name="ULD"
                     /note="Ubiquitin-like oligomerization domain of SATB;
                     pfam16534"
                     /db_xref="CDD:435405"
     Site            order(75,77,94..98,100,132,134,137..138,144..147,155..156,
                     159..161,163..164)
                     /site_type="other"
                     /note="tetramer interface [polypeptide binding]"
                     /db_xref="CDD:211426"
     Site            136
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q01826; propagated from
                     UniProtKB/Swiss-Prot (Q60611.2)"
     Region          139..143
                     /region_name="Protein interaction. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60611.2)"
     Region          176..247
                     /region_name="CUTL"
                     /note="CUT1-like DNA-binding domain of SATB; pfam16557"
                     /db_xref="CDD:435427"
     Site            185
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q01826; propagated from
                     UniProtKB/Swiss-Prot (Q60611.2)"
     Region          224..278
                     /region_name="Nuclear matrix targeting sequence (NMTS)"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60611.2)"
     Region          224..278
                     /region_name="Nuclear matrix targeting sequence (NMTS).
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60611.2)"
     Site            254..255
                     /site_type="cleavage"
                     /note="Cleavage, by caspases; propagated from
                     UniProtKB/Swiss-Prot (Q60611.2)"
     Region          266..307
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60611.2)"
     Region          372..444
                     /region_name="CUT"
                     /note="CUT domain; pfam02376"
                     /db_xref="CDD:426745"
     Region          450..474
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60611.2)"
     Region          497..567
                     /region_name="CUT"
                     /note="CUT domain; pfam02376"
                     /db_xref="CDD:426745"
     Site            637
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q60611.2)"
     Region          644..701
                     /region_name="HOX"
                     /note="Homeodomain; smart00389"
                     /db_xref="CDD:197696"
     Site            order(646..649,651,669,675,688,690..691,694..695,697..699,
                     701..702)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     Site            order(647,650,691,694..695,698)
                     /site_type="other"
                     /note="specific DNA base contacts [nucleotide binding]"
                     /db_xref="CDD:238039"
     CDS             1..763
                     /gene="Satb1"
                     /gene_synonym="2610306G12Rik"
                     /coded_by="NM_001357637.1:452..2743"
                     /note="isoform 3 is encoded by transcript variant 7"
                     /db_xref="GeneID:20230"
                     /db_xref="MGI:MGI:105084"
ORIGIN      
        1 mdhlneatqg kehsemsnnv sdpkgppaki arleqngspl grgrlgstgg kmqgvplkhs
       61 ghlmktnlrk gtmlpvfcvv ehyenaieyd ckeehaefvl vrkdmlfnql iemallslgy
      121 shssaaqakg liqvgkwnpv plsyvtdapd atvadmlqdv yhvvtlkiql hscpkledlp
      181 peqwshttvr nalkdllkdm nqsslakecp lsqsmissiv nstyyanvsa akcqefgrwy
      241 khfkktkdmm vemdslsels qqganhvnfg qqpvpgntae qppspaqlsh gsqpsvrtpl
      301 pnlhpglvst pispqlvnqq lvmaqllnqq yavnrllaqq slnqqylnhp ppvsrsmnkp
      361 leqqvstnte vsseiyqwvr delkragisq avfarvafnr tqgllseilr keedpktasq
      421 sllvnlramq nflqlpeaer driyqderer slnaasamgp apllstppsr ppqvktatla
      481 terngkpenn tmninasiyd eiqqemkrak vsqalfakva atksqgwlce llrwkedpsp
      541 enrtlwenls mirrflslpq perdaiyeqe snavhhhgdr pphiihvpae qiqqqqqqqq
      601 qqqqqqpppp ppqpqpqpqa gprlpprqpt vassaesdee nrqktrprtk isvealgilq
      661 sfiqdvglyp deeaiqtlsa qldlpkytii kffqnqryyl khhgklkdns glevdvaeyk
      721 deellkdlee svqdknantl fsvkleeels vegstdvnad lkd
//
LOCUS       NP_001351351             692 aa            linear   ROD 09-OCT-2023
DEFINITION  pro-neuregulin-1, membrane-bound isoform isoform 3 [Mus musculus].
ACCESSION   NP_001351351 XP_017168125
VERSION     NP_001351351.1
DBSOURCE    REFSEQ: accession NM_001364422.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 692)
  AUTHORS   Mikami Y, Iwase F, Ohshima D, Tomida T and Adachi-Akahane S.
  TITLE     Compensatory role of neuregulin-1 in diabetic cardiomyopathy
  JOURNAL   J Pharmacol Sci 153 (3), 130-141 (2023)
   PUBMED   37770154
  REMARK    GeneRIF: Compensatory role of neuregulin-1 in diabetic
            cardiomyopathy.
REFERENCE   2  (residues 1 to 692)
  AUTHORS   Qiao XY, Wang Y, Zhang W, Li Q, Liu C, Dao JJ, Qiao CM, Cui C, Shen
            YQ and Zhao WJ.
  TITLE     Involvement of CXCL10 in Neuronal Damage under the Condition of
            Spinal Cord Injury and the Potential Therapeutic Effect of Nrg1
  JOURNAL   J Integr Neurosci 22 (4), 96 (2023)
   PUBMED   37519170
  REMARK    GeneRIF: Involvement of CXCL10 in Neuronal Damage under the
            Condition of Spinal Cord Injury and the Potential Therapeutic
            Effect of Nrg1.
REFERENCE   3  (residues 1 to 692)
  AUTHORS   Liu H, Lu P, He S, Luo Y, Fang Y, Benkaci S, Wu B, Wang Y and Zhou
            B.
  TITLE     beta-Catenin regulates endocardial cushion growth by suppressing
            p21
  JOURNAL   Life Sci Alliance 6 (9), e202302163 (2023)
   PUBMED   37385754
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 692)
  AUTHORS   Kong L, Hassinan CW, Gerstner F, Buettner JM, Petigrow JB, Valdivia
            DO, Chan-Cortes MH, Mistri A, Cao A, McGaugh SA, Denton M, Brown S,
            Ross J, Schwab MH, Simon CM and Sumner CJ.
  TITLE     Boosting neuregulin 1 type-III expression hastens SMA motor axon
            maturation
  JOURNAL   Acta Neuropathol Commun 11 (1), 53 (2023)
   PUBMED   36997967
  REMARK    GeneRIF: Boosting neuregulin 1 type-III expression hastens SMA
            motor axon maturation.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 692)
  AUTHORS   Zhang X, Xiao G, Johnson C, Cai Y, Horowitz ZK, Mennicke C, Coffey
            R, Haider M, Threadgill D, Eliscu R, Oldham MC, Greenbaum A and
            Ghashghaei HT.
  TITLE     Bulk and mosaic deletions of Egfr reveal regionally defined
            gliogenesis in the developing mouse forebrain
  JOURNAL   iScience 26 (3), 106242 (2023)
   PUBMED   36915679
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 692)
  AUTHORS   Gassmann M, Casagranda F, Orioli D, Simon H, Lai C, Klein R and
            Lemke G.
  TITLE     Aberrant neural and cardiac development in mice lacking the ErbB4
            neuregulin receptor
  JOURNAL   Nature 378 (6555), 390-394 (1995)
   PUBMED   7477376
REFERENCE   7  (residues 1 to 692)
  AUTHORS   Meyer,D. and Birchmeier,C.
  TITLE     Multiple essential functions of neuregulin in development
  JOURNAL   Nature 378 (6555), 386-390 (1995)
   PUBMED   7477375
  REMARK    Erratum:[Nature 1995 Dec 14;378(6558):753]
REFERENCE   8  (residues 1 to 692)
  AUTHORS   Moscoso LM, Chu GC, Gautam M, Noakes PG, Merlie JP and Sanes JR.
  TITLE     Synapse-associated expression of an acetylcholine receptor-inducing
            protein, ARIA/heregulin, and its putative receptors, ErbB2 and
            ErbB3, in developing mammalian muscle
  JOURNAL   Dev Biol 172 (1), 158-169 (1995)
   PUBMED   7589796
REFERENCE   9  (residues 1 to 692)
  AUTHORS   Yang Y, Spitzer E, Meyer D, Sachs M, Niemann C, Hartmann G, Weidner
            KM, Birchmeier C and Birchmeier W.
  TITLE     Sequential requirement of hepatocyte growth factor and neuregulin
            in the morphogenesis and differentiation of the mammary gland
  JOURNAL   J Cell Biol 131 (1), 215-226 (1995)
   PUBMED   7559778
REFERENCE   10 (residues 1 to 692)
  AUTHORS   Ho WH, Armanini MP, Nuijens A, Phillips HS and Osheroff PL.
  TITLE     Sensory and motor neuron-derived factor. A novel heregulin variant
            highly expressed in sensory and motor neurons
  JOURNAL   J Biol Chem 270 (24), 14523-14532 (1995)
   PUBMED   7782315
  REMARK    Erratum:[J Biol Chem. 1995 Nov 3;270(44):26722. PMID: 7592900]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132407.3 and AC127374.4.
            
            On Jun 16, 2018 this sequence version replaced XP_017168125.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.81953.1,
                                           SRR7345562.726293.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..692
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 18.75 cM"
     Protein         1..692
                     /product="pro-neuregulin-1, membrane-bound isoform isoform
                     3"
                     /note="heregulin; type III neuregulin 1; type I neuregulin
                     1; pro-neuregulin-1, membrane-bound isoform"
                     /calculated_mol_wt=75417
     Region          245..275
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          319..674
                     /region_name="Neuregulin"
                     /note="Neuregulin family; pfam02158"
                     /db_xref="CDD:426627"
     CDS             1..692
                     /gene="Nrg1"
                     /gene_synonym="6030402G23Rik; ARIA; D230005F13Rik; GGF;
                     GGFII; Hgl; HRG; HRGalpha; NDF; Pro-NRG1; SMDF"
                     /coded_by="NM_001364422.1:641..2719"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="GeneID:211323"
                     /db_xref="MGI:MGI:96083"
ORIGIN      
        1 meiyppdmse gaggrsssps tqlsadpsld glpaaehmpd thtedgrspg llglavpccv
       61 cleaerlrgc lnsekicivp ilaclvslcl ciaglkwvfv dkifeydspt hldpgglgqd
      121 pvisldptaa savlvsseay tspvskaqse aeahvtgqgd hvavasepsa vptrknrlsa
      181 fpplhstppp fpspartpev rtpksgtqpq ttetnlqtap klstststtg tshlikcaek
      241 ektfcvngge cfmvkdlsnp srylckcpne ftgdrcqnyv masfykaeel yqkrvltitg
      301 iciallvvgi mcvvaycktk kqrqklhdrl rqslrsernn mvniangphh pnpppenvql
      361 vnqyvsknvi ssehiverev etsfstshyt stahhsttvt qtpshswsng htesiisesh
      421 svimmssven srhsspaggp rgrlhglggp recnsflrha retpdsyrds phseryvsam
      481 ttparmspvd fhtpsspksp psemsppvss mtvsmpsvav spfveeerpl llvtpprlre
      541 kkydhhpqql nsfhhnpahq stslppsplr ivedeeyett qeyepiqepi kkvtnsrrak
      601 rtkpnghian rlemdsnpss vssnsesete dervgedtpf lgiqnplaas levapafrla
      661 esrtnpagrf stqeelqarl ssvianqdpi av
//
LOCUS       NP_001349211             534 aa            linear   ROD 09-OCT-2023
DEFINITION  CUGBP Elav-like family member 4 isoform 8 [Mus musculus].
ACCESSION   NP_001349211 XP_017173277
VERSION     NP_001349211.1
DBSOURCE    REFSEQ: accession NM_001362282.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 534)
  AUTHORS   Salamon I, Park Y, Miskic T, Kopic J, Matteson P, Page NF, Roque A,
            McAuliffe GW, Favate J, Garcia-Forn M, Shah P, Judas M, Millonig
            JH, Kostovic I, De Rubeis S, Hart RP, Krsnik Z and Rasin MR.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    GeneRIF: Celf4 controls mRNA translation underlying synaptic
            development in the prenatal mammalian neocortex.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 534)
  AUTHORS   Shen Y, Zhang C, Xiao K, Liu D and Xie G.
  TITLE     CELF4 regulates spine formation and depression-like behaviors of
            mice
  JOURNAL   Biochem Biophys Res Commun 605, 39-44 (2022)
   PUBMED   35306363
  REMARK    GeneRIF: CELF4 regulates spine formation and depression-like
            behaviors of mice.
REFERENCE   3  (residues 1 to 534)
  AUTHORS   Moreau MX, Saillour Y, Cwetsch AW, Pierani A and Causeret F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   4  (residues 1 to 534)
  AUTHORS   Li C, Li X, Bi Z, Sugino K, Wang G, Zhu T and Liu Z.
  TITLE     Comprehensive transcriptome analysis of cochlear spiral ganglion
            neurons at multiple ages
  JOURNAL   Elife 9, e50491 (2020)
   PUBMED   31913118
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 534)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 534)
  AUTHORS   Ladd AN, Taffet G, Hartley C, Kearney DL and Cooper TA.
  TITLE     Cardiac tissue-specific repression of CELF activity disrupts
            alternative splicing and causes cardiomyopathy
  JOURNAL   Mol Cell Biol 25 (14), 6267-6278 (2005)
   PUBMED   15988035
  REMARK    GeneRIF: CELF protein activity is required for normal alternative
            splicing in the heart in vivo and normal CELF-mediated alternative
            splicing regulation is in turn required for normal cardiac
            function.
REFERENCE   7  (residues 1 to 534)
  AUTHORS   Meins M, Schlickum S, Wilhelm C, Missbach J, Yadav S, Glaser B,
            Grzmil M, Burfeind P and Laccone F.
  TITLE     Identification and characterization of murine Brunol4, a new member
            of the elav/bruno family
  JOURNAL   Cytogenet Genome Res 97 (3-4), 254-260 (2002)
   PUBMED   12438720
  REMARK    GeneRIF: cloning and characterization
REFERENCE   8  (residues 1 to 534)
  AUTHORS   Ladd AN, Charlet N and Cooper TA.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   9  (residues 1 to 534)
  AUTHORS   Good PJ, Chen Q, Warner SJ and Herring DC.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
REFERENCE   10 (residues 1 to 534)
  AUTHORS   Yulug IG, Egan SE, See CG and Fisher EM.
  TITLE     Mapping GRB2, a signal transduction gene in the human and the mouse
  JOURNAL   Genomics 22 (2), 313-318 (1994)
   PUBMED   7806216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121094.8 and AC144938.3.
            
            On Apr 12, 2018 this sequence version replaced XP_017173277.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.310148.1,
                                           SRR1660819.5606.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..534
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 13.92 cM"
     Protein         1..534
                     /product="CUGBP Elav-like family member 4 isoform 8"
                     /note="CUG-BP- and ETR-3-like factor 4; bruno-like protein
                     4; RNA-binding protein BRUNOL-4; bruno-like 4, RNA binding
                     protein"
                     /calculated_mol_wt=56829
     Region          18..39
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          49..135
                     /region_name="RRM1_CELF3_4_5_6"
                     /note="RNA recognition motif 1 (RRM1) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12632"
                     /db_xref="CDD:410041"
     Site            order(55,57,59..60,63,82,84,86,95..97,99,129,131)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410041"
     Region          121..149
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          150..230
                     /region_name="RRM2_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12635"
                     /db_xref="CDD:410043"
     Site            order(152,154,156..157,160,179,181,183,191..193,195,225,
                     227)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410043"
     Region          238..257
                     /region_name="Necessary for TNNT2 exon 5 inclusion.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          415..>443
                     /region_name="RRM_SF"
                     /note="RNA recognition motif (RRM) superfamily; cl17169"
                     /db_xref="CDD:450164"
     CDS             1..534
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /coded_by="NM_001362282.1:531..2135"
                     /note="isoform 8 is encoded by transcript variant 14"
                     /db_xref="GeneID:108013"
                     /db_xref="MGI:MGI:1932407"
ORIGIN      
        1 myikmatlan gqadnaslst nglgsspgsa ghmnglshsp gnpstipmkd hdaiklfigq
       61 iprnldekdl kplfeefgki yeltvlkdrf tgmhkgcafl tyceresalk aqsalheqkt
      121 lpgmnrpiqv kpadsesrgg ssclrqppsh rklfvgmlnk qqseddvrrl feafgnieec
      181 tilrgpdgns kgcafvkyss haeaqaaina lhgsqtmpga ssslvvkfad tdkertmrrm
      241 qqmagqmgmf npmaipfgay gayaqalmqq qaalmasvaq ggylnpmaaf aaaqmqqmaa
      301 lnmnglaaap mtptsggstp pgitapavps ipspigvngf tglppqangq paaeavfang
      361 ihpypaqspt aadplqqaya gvqqyagpay paaygqisqa fpqpppmipq qqregpegcn
      421 lliyhlpqef gdaelmqmfl pfgrhpvpsr cqapscqggq caisssarrl relrqpgqrt
      481 drhpgherlp drheeaqgaa eaaqrrqspv lsaggsvprg rpglaqgrml nglh
//
LOCUS       NP_109636                930 aa            linear   ROD 09-OCT-2023
DEFINITION  endoplasmic reticulum aminopeptidase 1 precursor [Mus musculus].
ACCESSION   NP_109636
VERSION     NP_109636.1
DBSOURCE    REFSEQ: accession NM_030711.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 930)
  AUTHORS   Ryu HM, Islam SMS, Sayeed HM, Babita R, Seong JK, Lee H and Sohn S.
  TITLE     Characterization of immune responses associated with ERAP-1
            expression in HSV-induced Behcet's disease mouse model
  JOURNAL   Clin Immunol 250, 109305 (2023)
   PUBMED   37003592
  REMARK    GeneRIF: Characterization of immune responses associated with
            ERAP-1 expression in HSV-induced Behcet's disease mouse model.
REFERENCE   2  (residues 1 to 930)
  AUTHORS   Geiger KM, Manoharan M, Coombs R, Arana K, Park CS, Lee AY, Shastri
            N, Robey EA and Coscoy L.
  TITLE     Murine cytomegalovirus downregulates ERAAP and induces an
            unconventional T cell response to self
  JOURNAL   Cell Rep 42 (4), 112317 (2023)
   PUBMED   36995940
  REMARK    GeneRIF: Murine cytomegalovirus downregulates ERAAP and induces an
            unconventional T cell response to self.
REFERENCE   3  (residues 1 to 930)
  AUTHORS   Niu Y, Jiang H, Yin H, Wang F, Hu R, Hu X, Peng B, Shu Y, Li Z,
            Chen S and Guo F.
  TITLE     Hepatokine ERAP1 Disturbs Skeletal Muscle Insulin Sensitivity Via
            Inhibiting USP33-Mediated ADRB2 Deubiquitination
  JOURNAL   Diabetes 71 (5), 921-933 (2022)
   PUBMED   35192681
REFERENCE   4  (residues 1 to 930)
  AUTHORS   Blake MK, O'Connell P, Pepelyayeva Y, Godbehere S, Aldhamen YA and
            Amalfitano A.
  TITLE     ERAP1 is a critical regulator of inflammasome-mediated
            proinflammatory and ER stress responses
  JOURNAL   BMC Immunol 23 (1), 9 (2022)
   PUBMED   35246034
  REMARK    GeneRIF: ERAP1 is a critical regulator of inflammasome-mediated
            proinflammatory and ER stress responses.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 930)
  AUTHORS   O'Connell P, Blake MK, Godbehere S, Aldhamen YA and Amalfitano A.
  TITLE     Absence of ERAP1 in B Cells Increases Susceptibility to Central
            Nervous System Autoimmunity, Alters B Cell Biology, and
            Mechanistically Explains Genetic Associations between ERAP1 and
            Multiple Sclerosis
  JOURNAL   J Immunol 207 (12), 2952-2965 (2021)
   PUBMED   34810226
  REMARK    GeneRIF: Absence of ERAP1 in B Cells Increases Susceptibility to
            Central Nervous System Autoimmunity, Alters B Cell Biology, and
            Mechanistically Explains Genetic Associations between ERAP1 and
            Multiple Sclerosis.
REFERENCE   6  (residues 1 to 930)
  AUTHORS   Yan J, Parekh VV, Mendez-Fernandez Y, Olivares-Villagomez D,
            Dragovic S, Hill T, Roopenian DC, Joyce S and Van Kaer L.
  TITLE     In vivo role of ER-associated peptidase activity in tailoring
            peptides for presentation by MHC class Ia and class Ib molecules
  JOURNAL   J Exp Med 203 (3), 647-659 (2006)
   PUBMED   16505142
REFERENCE   7  (residues 1 to 930)
  AUTHORS   Hammer GE, Gonzalez F, Champsaur M, Cado D and Shastri N.
  TITLE     The aminopeptidase ERAAP shapes the peptide repertoire displayed by
            major histocompatibility complex class I molecules
  JOURNAL   Nat Immunol 7 (1), 103-112 (2006)
   PUBMED   16299505
REFERENCE   8  (residues 1 to 930)
  AUTHORS   Yamazaki T, Akada T, Niizeki O, Suzuki T, Miyashita H and Sato Y.
  TITLE     Puromycin-insensitive leucyl-specific aminopeptidase (PILSAP) binds
            and catalyzes PDK1, allowing VEGF-stimulated activation of S6K for
            endothelial cell proliferation and angiogenesis
  JOURNAL   Blood 104 (8), 2345-2352 (2004)
   PUBMED   15187024
REFERENCE   9  (residues 1 to 930)
  AUTHORS   Serwold T, Gonzalez F, Kim J, Jacob R and Shastri N.
  TITLE     ERAAP customizes peptides for MHC class I molecules in the
            endoplasmic reticulum
  JOURNAL   Nature 419 (6906), 480-483 (2002)
   PUBMED   12368856
  REMARK    GeneRIF: identification of ERAAP, the aminopeptidase associated
            with antigen processing in the endoplasmic reticulum (ERAAP)
REFERENCE   10 (residues 1 to 930)
  AUTHORS   Miyashita H, Yamazaki T, Akada T, Niizeki O, Ogawa M, Nishikawa S
            and Sato Y.
  TITLE     A mouse orthologue of puromycin-insensitive leucyl-specific
            aminopeptidase is expressed in endothelial cells and plays an
            important role in angiogenesis
  JOURNAL   Blood 99 (9), 3241-3249 (2002)
   PUBMED   11964289
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC138120.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036559.1, AK030329.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..930
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 40.48 cM"
     Protein         1..930
                     /product="endoplasmic reticulum aminopeptidase 1
                     precursor"
                     /note="type 1 tumor necrosis factor receptor shedding
                     aminopeptidase regulator; adipocyte-derived leucine
                     aminopeptidase; aminopeptidase PILS; VEGF-induced
                     aminopeptidase; puromycin-insensitive leucyl-specific
                     aminopeptidase"
                     /calculated_mol_wt=104440
     sig_peptide     1..20
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=2178
     Site            3..23
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQH2.2)"
     Region          50..515
                     /region_name="M1_APN-Q_like"
                     /note="Peptidase M1 aminopeptidase N catalytic domain
                     family which includes aminopeptidase N (APN),
                     aminopeptidase Q (APQ), tricorn interacting factor F3, and
                     endoplasmic reticulum aminopeptidase 1 (ERAP1); cd09601"
                     /db_xref="CDD:341064"
     Site            59
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9EQH2.2)"
     Site            143
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9EQH2.2)"
     Site            order(170,172,306..309,342..343,346,365,369,422,427)
                     /site_type="active"
                     /db_xref="CDD:341064"
     Site            403
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9EQH2.2)"
     Site            427
                     /site_type="other"
                     /note="Transition state stabilizer. /evidence=ECO:0000250;
                     propagated from UniProtKB/Swiss-Prot (Q9EQH2.2)"
     Region          586..905
                     /region_name="ERAP1_C"
                     /note="ERAP1-like C-terminal domain; pfam11838"
                     /db_xref="CDD:432117"
     Site            655
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9EQH2.2)"
     Site            749
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9EQH2.2)"
     Site            890
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9EQH2.2)"
     CDS             1..930
                     /gene="Erap1"
                     /gene_synonym="A-LAP; ARTS-1; Arts1; ERAAP; PILSA; PILSAP"
                     /coded_by="NM_030711.5:95..2887"
                     /db_xref="CCDS:CCDS26647.1"
                     /db_xref="GeneID:80898"
                     /db_xref="MGI:MGI:1933403"
ORIGIN      
        1 mpsllplvlt flsvsspswc qnsdieslka sngdsfpwnn mrlpeymtpi hydlmihanl
       61 stltfwgkte veiiasrpts tiimhshhlq iskatlrrga gemlseeplk vleypaheqv
      121 allaaqplla gslytviidy aanlsesfhg fykstyrtqe gemrilaatq feptaarmaf
      181 pcfdepalka sfsikikrdp rhlaisnmpl vksvnvaegl iedhfditvk mstylvafii
      241 sdfksvskmt ksgvkvsvya vpdkinqady aldaavtlle fyedyfnipy plpkqdlaai
      301 pdfqsgamen wglttyress llydkekssa ssklgitmiv shelahqwfg nlvtmewwnd
      361 lwlnegfakf mefvsvtvth pelkvedyff gkcfnamevd alnsshpvst pvenpaqire
      421 mfddvsyekg acilnmlrdy lsadtfkrgi vqylqkysyk ntknedlwns mmhicptdgt
      481 qtmdgfcsrs qhssstshwr qevvdvktmm ntwtlqkgfp lititvsgrn vhmkqehymk
      541 gserfpetgy lwhvpltfit sksdsvqrfl lktktdvlil peavqwikfn vgmngyyivh
      601 yaddgwasls gllkeahtti ssndraslin nafqlvsiek lsiekaldlt lylkneteim
      661 pifqalneli pmyklmekrd mievetqfkd fllkllkdli dkqtwtdegs vsermlrsql
      721 lllacvrnyq pcvqraeryf rewkssngnm sipidvtlav favgaqnteg wdflyskyqs
      781 slssteksqi efslctskdp eklqwlldqs fkgeiiktqe fphiltligr npvgyplawk
      841 flrenwnklv qkfelgsssi ahmvmgttdq fstrarleev kgffsslken gsqlrcvqqt
      901 ietieenirw mdknfdkirl wlqkekpell
//
LOCUS       NP_001103777             624 aa            linear   ROD 09-OCT-2023
DEFINITION  kelch-like ECH-associated protein 1 [Mus musculus].
ACCESSION   NP_001103777
VERSION     NP_001103777.1
DBSOURCE    REFSEQ: accession NM_001110307.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 624)
  AUTHORS   Li F, Huang H, Zhao P, Jiang J, Ding X, Lu D and Ji L.
  TITLE     Curculigoside mitigates dextran sulfate sodium-induced colitis by
            activation of KEAP1-NRF2 interaction to inhibit oxidative damage
            and autophagy of intestinal epithelium barrier
  JOURNAL   Int J Mol Med 52 (5) (2023)
   PUBMED   37772380
  REMARK    GeneRIF: Curculigoside mitigates dextran sulfate sodium-induced
            colitis by activation of KEAP1-NRF2 interaction to inhibit
            oxidative damage and autophagy of intestinal epithelium barrier.
REFERENCE   2  (residues 1 to 624)
  AUTHORS   Baird L, Taguchi K, Zhang A, Takahashi Y, Suzuki T, Kensler TW and
            Yamamoto M.
  TITLE     A NRF2-induced secretory phenotype activates immune surveillance to
            remove irreparably damaged cells
  JOURNAL   Redox Biol 66, 102845 (2023)
   PUBMED   37597423
REFERENCE   3  (residues 1 to 624)
  AUTHORS   Zhang A, Suzuki T, Adachi S, Yoshida E, Sakaguchi S and Yamamoto M.
  TITLE     Nrf2 activation improves experimental rheumatoid arthritis
  JOURNAL   Free Radic Biol Med 207, 279-295 (2023)
   PUBMED   37494986
  REMARK    GeneRIF: Nrf2 activation improves experimental rheumatoid
            arthritis.
REFERENCE   4  (residues 1 to 624)
  AUTHORS   Ushimoto C, Sugiki S, Kunii K, Inoue S, Kuroda E, Akai R, Iwawaki T
            and Miyazawa K.
  TITLE     Dynamic change and preventive role of stress response via
            Keap1-Nrf2 during renal crystal formation
  JOURNAL   Free Radic Biol Med 207, 120-132 (2023)
   PUBMED   37451369
  REMARK    GeneRIF: Dynamic change and preventive role of stress response via
            Keap1-Nrf2 during renal crystal formation.
REFERENCE   5  (residues 1 to 624)
  AUTHORS   Zhou M, Barkema HW, Gao J, Yang J, Wang Y, Kastelic JP, Khan S, Liu
            G and Han B.
  TITLE     MicroRNA miR-223 modulates NLRP3 and Keap1, mitigating
            lipopolysaccharide-induced inflammation and oxidative stress in
            bovine mammary epithelial cells and murine mammary glands
  JOURNAL   Vet Res 54 (1), 78 (2023)
   PUBMED   37710276
  REMARK    GeneRIF: MicroRNA miR-223 modulates NLRP3 and Keap1, mitigating
            lipopolysaccharide-induced inflammation and oxidative stress in
            bovine mammary epithelial cells and murine mammary glands.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 624)
  AUTHORS   Zipper LM and Mulcahy RT.
  TITLE     The Keap1 BTB/POZ dimerization function is required to sequester
            Nrf2 in cytoplasm
  JOURNAL   J Biol Chem 277 (39), 36544-36552 (2002)
   PUBMED   12145307
REFERENCE   7  (residues 1 to 624)
  AUTHORS   Dinkova-Kostova AT, Holtzclaw WD, Cole RN, Itoh K, Wakabayashi N,
            Katoh Y, Yamamoto M and Talalay P.
  TITLE     Direct evidence that sulfhydryl groups of Keap1 are the sensors
            regulating induction of phase 2 enzymes that protect against
            carcinogens and oxidants
  JOURNAL   Proc Natl Acad Sci U S A 99 (18), 11908-11913 (2002)
   PUBMED   12193649
  REMARK    GeneRIF: evidence that sulfhydryl groups of Keap1 are the sensors
            regulating induction of phase 2 enzymes that protect against
            carcinogens and oxidants
REFERENCE   8  (residues 1 to 624)
  AUTHORS   Kotilinek LA, Bacskai B, Westerman M, Kawarabayashi T, Younkin L,
            Hyman BT, Younkin S and Ashe KH.
  TITLE     Reversible memory loss in a mouse transgenic model of Alzheimer's
            disease
  JOURNAL   J Neurosci 22 (15), 6331-6335 (2002)
   PUBMED   12151510
REFERENCE   9  (residues 1 to 624)
  AUTHORS   Itoh K, Wakabayashi N, Katoh Y, Ishii T, Igarashi K, Engel JD and
            Yamamoto M.
  TITLE     Keap1 represses nuclear activation of antioxidant responsive
            elements by Nrf2 through binding to the amino-terminal Neh2 domain
  JOURNAL   Genes Dev 13 (1), 76-86 (1999)
   PUBMED   9887101
REFERENCE   10 (residues 1 to 624)
  AUTHORS   Chu CC and Paul WE.
  TITLE     Expressed genes in interleukin-4 treated B cells identified by cDNA
            representational difference analysis
  JOURNAL   Mol Immunol 35 (8), 487-502 (1998)
   PUBMED   9798653
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK004738.1 and BY586021.1.
            
            Transcript Variant: This variant (4) uses a different splice site
            in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 all
            encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004738.1, AK150437.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..624
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 7.74 cM"
     Protein         1..624
                     /product="kelch-like ECH-associated protein 1"
                     /note="NRF2 cytosolic inhibitor; cytosolic inhibitor of
                     Nrf2; ring canal protein"
                     /calculated_mol_wt=69422
     Region          56..180
                     /region_name="BTB_POZ_KLHL19_KEAP1"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in Kelch-like
                     ECH-associated protein 1 (KEAP1); cd18248"
                     /db_xref="CDD:349557"
     Region          95..596
                     /region_name="PHA03098"
                     /note="kelch-like protein; Provisional"
                     /db_xref="CDD:222983"
     Site            order(106,109..110,115..117,125..126,157,161..162)
                     /site_type="other"
                     /note="cullin binding site [polypeptide binding]"
                     /db_xref="CDD:349557"
     Site            order(129,131..132,147..148,150..151,154)
                     /site_type="other"
                     /note="modulator binding site [chemical binding]"
                     /db_xref="CDD:349557"
     Site            151
                     /site_type="other"
                     /note="Sensor for electrophilic agents.
                     /evidence=ECO:0000269|PubMed:18268004,
                     ECO:0000269|PubMed:22014577, ECO:0000269|PubMed:26527616;
                     propagated from UniProtKB/Swiss-Prot (Q9Z2X8.1)"
     Site            257
                     /site_type="other"
                     /note="Sensor for electrophilic agents.
                     /evidence=ECO:0000250|UniProtKB:Q14145; propagated from
                     UniProtKB/Swiss-Prot (Q9Z2X8.1)"
     Site            273
                     /site_type="other"
                     /note="Sensor for electrophilic agents.
                     /evidence=ECO:0000269|PubMed:14764894,
                     ECO:0000269|PubMed:26527616; propagated from
                     UniProtKB/Swiss-Prot (Q9Z2X8.1)"
     Site            288
                     /site_type="other"
                     /note="Sensor for electrophilic agents.
                     /evidence=ECO:0000269|PubMed:14764894,
                     ECO:0000269|PubMed:22014577, ECO:0000269|PubMed:26527616;
                     propagated from UniProtKB/Swiss-Prot (Q9Z2X8.1)"
     Region          327..372
                     /region_name="Kelch 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2X8.1)"
     Region          362..409
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          373..423
                     /region_name="Kelch 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2X8.1)"
     Region          413..456
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          424..470
                     /region_name="Kelch 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2X8.1)"
     Site            434
                     /site_type="other"
                     /note="Sensor for electrophilic agents.
                     /evidence=ECO:0000269|PubMed:20498371; propagated from
                     UniProtKB/Swiss-Prot (Q9Z2X8.1)"
     Region          460..503
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          471..517
                     /region_name="Kelch 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2X8.1)"
     Region          507..551
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          519..564
                     /region_name="Kelch 5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2X8.1)"
     Region          554..597
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          565..611
                     /region_name="Kelch 6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2X8.1)"
     CDS             1..624
                     /gene="Keap1"
                     /gene_synonym="INRF2; mKIAA0132"
                     /coded_by="NM_001110307.1:305..2179"
                     /db_xref="CCDS:CCDS22897.1"
                     /db_xref="GeneID:50868"
                     /db_xref="MGI:MGI:1858732"
ORIGIN      
        1 mqpepklsga prssqflplw skcpegagda vmyastecka evtpsqdgnr tfsytledht
       61 kqafgvmnel rlsqqlcdvt lqvkyedipa aqfmahkvvl assspvfkam ftnglreqgm
      121 evvsiegihp kvmerliefa ytasisvgek cvlhvmngav myqidsvvra csdflvqqld
      181 psnaigianf aeqigctelh qrareyiymh fgevakqeef fnlshcqlat lisrddlnvr
      241 cesevfhaci dwvkydcpqr rfyvqallra vrchaltprf lqtqlqkcei lqadarckdy
      301 lvqifqeltl hkptqavpcr apkvgrliyt aggyfrqsls yleaynpsng swlrladlqv
      361 prsglagcvv ggllyavggr nnspdgntds saldcynpmt nqwspcasms vprnrigvgv
      421 idghiyavgg shgcihhssv eryeperdew hlvapmltrr igvgvavlnr llyavggfdg
      481 tnrlnsaecy ypernewrmi tpmntirsga gvcvlhnciy aaggydgqdq lnsverydve
      541 tetwtfvapm rhhrsalgit vhqgkiyvlg gydghtflds vecydpdsdt wsevtrmtsg
      601 rsgvgvavtm epcrkqidqq nctc
//
LOCUS       NP_033852                998 aa            linear   ROD 09-OCT-2023
DEFINITION  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform a [Mus
            musculus].
ACCESSION   NP_033852
VERSION     NP_033852.1
DBSOURCE    REFSEQ: accession NM_009722.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 998)
  AUTHORS   Iida H, Kono T, Lee CC, Krishnan P, Arvin MC, Weaver SA, Jarvela
            TS, Branco RCS, McLaughlin MR, Bone RN, Tong X, Arvan P, Lindberg I
            and Evans-Molina C.
  TITLE     SERCA2 regulates proinsulin processing and processing enzyme
            maturation in pancreatic beta cells
  JOURNAL   Diabetologia 66 (11), 2042-2061 (2023)
   PUBMED   37537395
  REMARK    GeneRIF: SERCA2 regulates proinsulin processing and processing
            enzyme maturation in pancreatic beta cells.
REFERENCE   2  (residues 1 to 998)
  AUTHORS   Karatsai O, Lehka L, Wojton D, Grabowska AI, Duda MK, Lenartowski R
            and Redowicz MJ.
  TITLE     Unconventional myosin VI in the heart: Involvement in cardiac
            dysfunction progressing with age
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1869 (6), 166748 (2023)
   PUBMED   37169038
REFERENCE   3  (residues 1 to 998)
  AUTHORS   Chen HX, Wang XC, Hou HT, Wang J, Yang Q, Chen YL, Chen HZ and He
            GW.
  TITLE     Lysine crotonylation of SERCA2a correlates to cardiac dysfunction
            and arrhythmia in Sirt1 cardiac-specific knockout mice
  JOURNAL   Int J Biol Macromol 242 (Pt 4), 125151 (2023)
   PUBMED   37270127
  REMARK    GeneRIF: Lysine crotonylation of SERCA2a correlates to cardiac
            dysfunction and arrhythmia in Sirt1 cardiac-specific knockout mice.
REFERENCE   4  (residues 1 to 998)
  AUTHORS   Skogestad J, Albert I, Hougen K, Lothe GB, Lunde M, Eken OS, Veras
            I, Huynh NTT, Borstad M, Marshall S, Shen X, Louch WE, Robinson EL,
            Cleveland JC Jr, Ambardekar AV, Schwisow JA, Jonas E, Calejo AI,
            Morth JP, Tasken K, Melleby AO, Lunde PK, Sjaastad I, Carlson CR
            and Aronsen JM.
  TITLE     Disruption of Phosphodiesterase 3A Binding to SERCA2 Increases
            SERCA2 Activity and Reduces Mortality in Mice With Chronic Heart
            Failure
  JOURNAL   Circulation 147 (16), 1221-1236 (2023)
   PUBMED   36876489
  REMARK    GeneRIF: Disruption of Phosphodiesterase 3A Binding to SERCA2
            Increases SERCA2 Activity and Reduces Mortality in Mice With
            Chronic Heart Failure.
REFERENCE   5  (residues 1 to 998)
  AUTHORS   Ye B, Zhou H, Chen Y, Luo W, Lin W, Zhao Y, Han J, Han X, Huang W,
            Wu G, Wang X and Liang G.
  TITLE     USP25 Ameliorates Pathological Cardiac Hypertrophy by Stabilizing
            SERCA2a in Cardiomyocytes
  JOURNAL   Circ Res 132 (4), 465-480 (2023)
   PUBMED   36722348
  REMARK    GeneRIF: USP25 Ameliorates Pathological Cardiac Hypertrophy by
            Stabilizing SERCA2a in Cardiomyocytes.
REFERENCE   6  (residues 1 to 998)
  AUTHORS   Ko MS, Threat TA, Wang X, Horton JH, Cui Y, Wang X, Pryor E, Paris
            J, Wells-Smith J, Kitchen JR, Rowe LB, Eppig J, Satoh T, Brant L,
            Fujiwara H, Yotsumoto S and Nakashima H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
REFERENCE   7  (residues 1 to 998)
  AUTHORS   Ya J, Erdtsieck-Ernste EB, de Boer PA, van Kempen MJ, Jongsma H,
            Gros D, Moorman AF and Lamers WH.
  TITLE     Heart defects in connexin43-deficient mice
  JOURNAL   Circ Res 82 (3), 360-366 (1998)
   PUBMED   9486664
  REMARK    Review article
REFERENCE   8  (residues 1 to 998)
  AUTHORS   Harrer JM, Haghighi K, Kim HW, Ferguson DG and Kranias EG.
  TITLE     Coordinate regulation of SR Ca(2+)-ATPase and phospholamban
            expression in developing murine heart
  JOURNAL   Am J Physiol 272 (1 Pt 2), H57-H66 (1997)
   PUBMED   9038922
REFERENCE   9  (residues 1 to 998)
  AUTHORS   Hawkins C, Xu A and Narayanan N.
  TITLE     Sarcoplasmic reticulum calcium pump in cardiac and slow twitch
            skeletal muscle but not fast twitch skeletal muscle undergoes
            phosphorylation by endogenous and exogenous
            Ca2+/calmodulin-dependent protein kinase. Characterization of
            optimal conditions for calcium pump phosphorylation
  JOURNAL   J Biol Chem 269 (49), 31198-31206 (1994)
   PUBMED   7983062
REFERENCE   10 (residues 1 to 998)
  AUTHORS   Hsu DK, Donohue PJ, Alberts GF and Winkles JA.
  TITLE     Fibroblast growth factor-1 induces phosphofructokinase, fatty acid
            synthase and Ca(2+)-ATPase mRNA expression in NIH 3T3 cells
  JOURNAL   Biochem Biophys Res Commun 197 (3), 1483-1491 (1993)
   PUBMED   7506544
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ162528.1, AK220538.1 and BC054748.1.
            
            Transcript Variant: This variant (2) differs in the 3' coding
            region and 3' UTR, compared to variant 1. The resulting isoform
            (a), also known as SERCA2A, has a shorter and distinct C-terminus
            compared to isoform b.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ223584.1, SRR10223969.6018.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..998
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 62.38 cM"
     Protein         1..998
                     /product="sarcoplasmic/endoplasmic reticulum calcium
                     ATPase 2 isoform a"
                     /EC_number="7.2.2.10"
                     /note="sarcoplasmic/endoplasmic reticulum calcium ATPase
                     2; calcium pump 2; SR Ca(2+)-ATPase 2; endoplasmic
                     reticulum class 1/2 Ca(2+) ATPase; sarco/endoplasmic
                     reticulum Ca2+-ATPase 2"
                     /calculated_mol_wt=109623
     Region          5..988
                     /region_name="P-type_ATPase_SERCA"
                     /note="sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA),
                     similar to mammalian ATP2A1-3/SERCA1-3; cd02083"
                     /db_xref="CDD:319778"
     Site            38
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (O55143.2)"
     Site            49..69
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O55143.2)"
     Site            90..110
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O55143.2)"
     Site            254..273
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O55143.2)"
     Site            296..313
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O55143.2)"
     Site            order(309,795,799)
                     /site_type="other"
                     /note="Ca binding site [ion binding]"
                     /db_xref="CDD:319778"
     Site            order(351..353,442,487,489,492,494,514..516,559,561,
                     624..626,677,683,702,705)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:319778"
     Site            441
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q64578; propagated from
                     UniProtKB/Swiss-Prot (O55143.2)"
     Site            531
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (O55143.2)"
     Region          575..594
                     /region_name="Interaction with HAX1.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (O55143.2)"
     Site            580
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P16615; propagated from
                     UniProtKB/Swiss-Prot (O55143.2)"
     Site            661
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P11507; propagated from
                     UniProtKB/Swiss-Prot (O55143.2)"
     Site            663
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:19144319, ECO:0007744|PubMed:21183079;
                     propagated from UniProtKB/Swiss-Prot (O55143.2)"
     Site            757..776
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O55143.2)"
     Site            order(767,770,798..799,907)
                     /site_type="other"
                     /note="Ca binding site [ion binding]"
                     /db_xref="CDD:319778"
     Region          787..807
                     /region_name="Interaction with PLN.
                     /evidence=ECO:0000250|UniProtKB:P04191"
                     /note="propagated from UniProtKB/Swiss-Prot (O55143.2)"
     Site            787..807
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O55143.2)"
     Site            828..850
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O55143.2)"
     Site            897..916
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O55143.2)"
     Site            930..948
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O55143.2)"
     Region          931..942
                     /region_name="Interaction with PLN.
                     /evidence=ECO:0000250|UniProtKB:P04191"
                     /note="propagated from UniProtKB/Swiss-Prot (O55143.2)"
     Site            964..984
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O55143.2)"
     CDS             1..998
                     /gene="Atp2a2"
                     /gene_synonym="9530097L16Rik; D5Wsu150e; mKIAA4195;
                     SERCA2; Serca2a; SERCA2B"
                     /coded_by="NM_009722.3:541..3537"
                     /note="isoform a is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS57379.1"
                     /db_xref="GeneID:11938"
                     /db_xref="MGI:MGI:88110"
ORIGIN      
        1 menahtktve evlghfgvne stglsleqvk klkerwgsne lpaeegktll elvieqfedl
       61 lvrilllaac isfvlawfee geetitafve pfvillilva naivgvwqer naenaiealk
      121 eyepemgkvy rqdrksvqri kakdivpgdi veiavgdkvp adirltsiks ttlrvdqsil
      181 tgesvsvikh tdpvpdprav nqdkknmlfs gtniaagkam gvvvatgvnt eigkirdemv
      241 ateqertplq qkldefgeql skvislicia vwiinighfn dpvhggswir gaiyyfkiav
      301 alavaaipeg lpavittcla lgtrrmakkn aivrslpsve tlgctsvics dktgtlttnq
      361 msvcrmfild kvegdtcsln efsitgstya pigevqkddk pvkchqydgl velaticalc
      421 ndsaldynea kgvyekvgea tetaltclve kmnvfdtelk glskierana cnsvikqlmk
      481 keftlefsrd rksmsvyctp nkpsrtsmsk mfvkgapegv idrcthirvg stkvpmtpgv
      541 kqkimsvire wgsgsdtlrc lalathdnpl kreemhleds anfikyetnl tfvgcvgmld
      601 pprievassv klcrqagirv imitgdnkgt avaicrrigi fgqdedvtsk aftgrefdel
      661 spsaqrdacl narcfarvep shkskivefl qsfdeitamt gdgvndapal kkseigiamg
      721 sgtavaktas emvladdnfs tivaaveegr aiynnmkqfi rylissnvge vvcifltaal
      781 gfpealipvq llwvnlvtdg lpatalgfnp pdldimnkpp rnpkeplisg wlffrylaig
      841 cyvgaatvga aawwfiaadg gprvsfyqls hflqckednp dfdgvdcaif espypmtmal
      901 svlvtiemcn alnslsenqs llrmppweni wlvgsiclsm slhflilyve plplifqitp
      961 lnltqwlmvl kislpvilmd etlkfvarny leqpaile
//
LOCUS       NP_001404201             247 aa            linear   ROD 09-OCT-2023
DEFINITION  syntaxin-4 isoform 2 [Mus musculus].
ACCESSION   NP_001404201 XP_030098171
VERSION     NP_001404201.1
DBSOURCE    REFSEQ: accession NM_001417272.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 247)
  AUTHORS   Tondeur EGM, Voerman JSA, Geleijnse MAA, van Hofwegen LS, van
            Krimpen A, Koerner J, Mishra G, Song Z and Schliehe C.
  TITLE     Sec22b and Stx4 Depletion Has No Major Effect on Cross-Presentation
            of PLGA Microsphere-Encapsulated Antigen and a Synthetic Long
            Peptide In Vitro
  JOURNAL   J Immunol 211 (8), 1203-1215 (2023)
   PUBMED   37638825
  REMARK    GeneRIF: Sec22b and Stx4 Depletion Has No Major Effect on
            Cross-Presentation of PLGA Microsphere-Encapsulated Antigen and a
            Synthetic Long Peptide In Vitro.
REFERENCE   2  (residues 1 to 247)
  AUTHORS   Black HL, Livingstone R, Mastick CC, Al Tobi M, Taylor H, Geiser A,
            Stirrat L, Kioumourtzoglou D, Petrie JR, Boyle JG, Bryant NJ and
            Gould GW.
  TITLE     Knockout of syntaxin-4 in 3T3-L1 adipocytes reveals new insight
            into GLUT4 trafficking and adiponectin secretion
  JOURNAL   J Cell Sci 135 (1) (2022)
   PUBMED   34859814
  REMARK    GeneRIF: Knockout of syntaxin-4 in 3T3-L1 adipocytes reveals new
            insight into GLUT4 trafficking and adiponectin secretion.
REFERENCE   3  (residues 1 to 247)
  AUTHORS   Merz KE, Hwang J, Zhou C, Veluthakal R, McCown EM, Hamilton A, Oh
            E, Dai W, Fueger PT, Jiang L, Huss JM and Thurmond DC.
  TITLE     Enrichment of the exocytosis protein STX4 in skeletal muscle
            remediates peripheral insulin resistance and alters mitochondrial
            dynamics via Drp1
  JOURNAL   Nat Commun 13 (1), 424 (2022)
   PUBMED   35058456
  REMARK    GeneRIF: Enrichment of the exocytosis protein STX4 in skeletal
            muscle remediates peripheral insulin resistance and alters
            mitochondrial dynamics via Drp1.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 247)
  AUTHORS   Oh E, McCown EM, Ahn M, Garcia PA, Branciamore S, Tang S, Zeng DF,
            Roep BO and Thurmond DC.
  TITLE     Syntaxin 4 Enrichment in beta-Cells Prevents Conversion to
            Autoimmune Diabetes in Non-Obese Diabetic (NOD) Mice
  JOURNAL   Diabetes 70 (12), 2837-2849 (2021)
   PUBMED   34556496
  REMARK    GeneRIF: Syntaxin 4 Enrichment in beta-Cells Prevents Conversion to
            Autoimmune Diabetes in Non-Obese Diabetic (NOD) Mice.
REFERENCE   5  (residues 1 to 247)
  AUTHORS   Sanchez E, Gonzalez EA, Moreno DS, Cardenas RA, Ramos MA, Davalos
            AJ, Manllo J, Rodarte AI, Petrova Y, Moreira DC, Chavez MA,
            Tortoriello A, Lara A, Gutierrez BA, Burns AR, Heidelberger R and
            Adachi R.
  TITLE     Syntaxin 3, but not syntaxin 4, is required for mast cell-regulated
            exocytosis, where it plays a primary role mediating compound
            exocytosis
  JOURNAL   J Biol Chem 294 (9), 3012-3023 (2019)
   PUBMED   30563839
  REMARK    GeneRIF: the residual exocytic function of Stx3-deficient MCs was
            sufficient to drive a full anaphylactic response in mice
REFERENCE   6  (residues 1 to 247)
  AUTHORS   Lehtonen S, Riento K, Olkkonen VM and Lehtonen E.
  TITLE     Syntaxin 3 and Munc-18-2 in epithelial cells during kidney
            development
  JOURNAL   Kidney Int 56 (3), 815-826 (1999)
   PUBMED   10469351
REFERENCE   7  (residues 1 to 247)
  AUTHORS   Min J, Okada S, Kanzaki M, Elmendorf JS, Coker KJ, Ceresa BP, Syu
            LJ, Noda Y, Saltiel AR and Pessin JE.
  TITLE     Synip: a novel insulin-regulated syntaxin 4-binding protein
            mediating GLUT4 translocation in adipocytes
  JOURNAL   Mol Cell 3 (6), 751-760 (1999)
   PUBMED   10394363
  REMARK    Erratum:[Mol Cell 1999 Jul;4(1):following 142]
REFERENCE   8  (residues 1 to 247)
  AUTHORS   Gerst JE.
  TITLE     SNAREs and SNARE regulators in membrane fusion and exocytosis
  JOURNAL   Cell Mol Life Sci 55 (5), 707-734 (1999)
   PUBMED   10379359
  REMARK    Review article
REFERENCE   9  (residues 1 to 247)
  AUTHORS   Tellam JT, Macaulay SL, McIntosh S, Hewish DR, Ward CW and James
            DE.
  TITLE     Characterization of Munc-18c and syntaxin-4 in 3T3-L1 adipocytes.
            Putative role in insulin-dependent movement of GLUT-4
  JOURNAL   J Biol Chem 272 (10), 6179-6186 (1997)
   PUBMED   9045631
REFERENCE   10 (residues 1 to 247)
  AUTHORS   Katagiri H, Terasaki J, Murata T, Ishihara H, Ogihara T, Inukai K,
            Fukushima Y, Anai M, Kikuchi M, Miyazaki J et al.
  TITLE     A novel isoform of syntaxin-binding protein homologous to yeast
            Sec1 expressed ubiquitously in mammalian cells
  JOURNAL   J Biol Chem 270 (10), 4963-4966 (1995)
   PUBMED   7890599
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC149222.4.
            
            On Mar 2, 2023 this sequence version replaced XP_030098171.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.66540.1,
                                           SRR13422590.44128.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..247
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.77 cM"
     Protein         1..247
                     /product="syntaxin-4 isoform 2"
                     /note="syntaxin-4"
                     /calculated_mol_wt=28213
     Region          1..138
                     /region_name="SynN"
                     /note="Syntaxin N-terminus domain; syntaxins are nervous
                     system-specific proteins implicated in the docking of
                     synaptic vesicles with the presynaptic plasma membrane;
                     they are a family of receptors for intracellular transport
                     vesicles; each target membrane may...; cd00179"
                     /db_xref="CDD:238105"
     Site            order(18,29,32..33,40,44,47,54,76,81,84,90,97..98,
                     101..102,104..105,108,135)
                     /site_type="active"
                     /note="interdomain interaction site [active]"
                     /db_xref="CDD:238105"
     Site            order(115..125,134..138)
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238105"
     Region          148..209
                     /region_name="SNARE"
                     /note="SNARE motif; cl22856"
                     /db_xref="CDD:451431"
     Site            order(180,187,190)
                     /site_type="other"
                     /note="flanking leucine-zipper layers"
                     /db_xref="CDD:277192"
     Site            183
                     /site_type="active"
                     /note="zero layer [active]"
                     /db_xref="CDD:277192"
     Region          185..236
                     /region_name="SNARE"
                     /note="SNARE domain; pfam05739"
                     /db_xref="CDD:428611"
     CDS             1..247
                     /gene="Stx4a"
                     /gene_synonym="Stx4; Syn-4; Syn4"
                     /coded_by="NM_001417272.1:451..1194"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="GeneID:20909"
                     /db_xref="MGI:MGI:893577"
ORIGIN      
        1 makleskvre lekqqvtila tplpeesmkq glqnlreeik qlgrevraql kaiepqkeea
       61 denynsvntr mkktqhgvls qqfvelinkc nsmqseyrek nverirrqlk itnagmvsde
      121 eleqmldsgq sevfvsnilk dtqvtrqaln eisarhseiq qlersirelh eiftflatev
      181 emqgeminri eknilssady vergqehvki alenqkkark kkvmiaicvs vtvlilavii
      241 gititvg
//
LOCUS       NP_001032255             452 aa            linear   ROD 09-OCT-2023
DEFINITION  nuclear factor of activated T-cells, cytoplasmic 2 isoform c [Mus
            musculus].
ACCESSION   NP_001032255
VERSION     NP_001032255.1
DBSOURCE    REFSEQ: accession NM_001037178.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 452)
  AUTHORS   Fu Y, Wang J, Liu C, Liao K, Gao X, Tang R, Fan B, Hong Y, Xiao N,
            Xiao C and Liu WH.
  TITLE     Glycogen synthase kinase 3 controls T-cell exhaustion by regulating
            NFAT activation
  JOURNAL   Cell Mol Immunol 20 (10), 1127-1139 (2023)
   PUBMED   37553428
  REMARK    GeneRIF: Glycogen synthase kinase 3 controls T-cell exhaustion by
            regulating NFAT activation.
REFERENCE   2  (residues 1 to 452)
  AUTHORS   Wan X, Zhao S, Dai Y, Zhang J, Shen Y, Gong L and Le Q.
  TITLE     WNT16b promotes the proliferation and self-renewal of human limbal
            epithelial stem/progenitor cells via activating the
            calcium/calcineurin A/NFATC2 pathway
  JOURNAL   Cell Prolif 56 (10), e13460 (2023)
   PUBMED   36974338
  REMARK    GeneRIF: WNT16b promotes the proliferation and self-renewal of
            human limbal epithelial stem/progenitor cells via activating the
            calcium/calcineurin A/NFATC2 pathway.
REFERENCE   3  (residues 1 to 452)
  AUTHORS   Jiang F, Guo Y, Hu L, Zhang M, Meng J, Si Y and Shi H.
  TITLE     Role of nuclear factor of activated T Cells-1 in Sepsis-induced
            behavioral deficits in mice
  JOURNAL   Brain Res 1806, 148299 (2023)
   PUBMED   36842570
REFERENCE   4  (residues 1 to 452)
  AUTHORS   Nagai J, Lin J and Boyce JA.
  TITLE     Macrophage P2Y6 Receptor Signaling Selectively Activates NFATC2 and
            Suppresses Allergic Lung Inflammation
  JOURNAL   J Immunol 209 (12), 2293-2303 (2022)
   PUBMED   36307120
  REMARK    GeneRIF: Macrophage P2Y6 Receptor Signaling Selectively Activates
            NFATC2 and Suppresses Allergic Lung Inflammation.
REFERENCE   5  (residues 1 to 452)
  AUTHORS   Zhu L, Zhou X, Gu M, Kim J, Li Y, Ko CJ, Xie X, Gao T, Cheng X and
            Sun SC.
  TITLE     Dapl1 controls NFATc2 activation to regulate CD8+ T cell exhaustion
            and responses in chronic infection and cancer
  JOURNAL   Nat Cell Biol 24 (7), 1165-1176 (2022)
   PUBMED   35773432
REFERENCE   6  (residues 1 to 452)
  AUTHORS   Vihma H, Pruunsild P and Timmusk T.
  TITLE     Alternative splicing and expression of human and mouse NFAT genes
  JOURNAL   Genomics 92 (5), 279-291 (2008)
   PUBMED   18675896
REFERENCE   7  (residues 1 to 452)
  AUTHORS   Ho SN, Thomas DJ, Timmerman LA, Li X, Francke U and Crabtree GR.
  TITLE     NFATc3, a lymphoid-specific NFATc family member that is
            calcium-regulated and exhibits distinct DNA binding specificity
  JOURNAL   J Biol Chem 270 (34), 19898-19907 (1995)
   PUBMED   7650004
REFERENCE   8  (residues 1 to 452)
  AUTHORS   Jain J, Burgeon E, Badalian TM, Hogan PG and Rao A.
  TITLE     A similar DNA-binding motif in NFAT family proteins and the Rel
            homology region
  JOURNAL   J Biol Chem 270 (8), 4138-4145 (1995)
   PUBMED   7876165
REFERENCE   9  (residues 1 to 452)
  AUTHORS   Li X, Ho SN, Luna J, Giacalone J, Thomas DJ, Timmerman LA, Crabtree
            GR and Francke U.
  TITLE     Cloning and chromosomal localization of the human and murine genes
            for the T-cell transcription factors NFATc and NFATp
  JOURNAL   Cytogenet Cell Genet 68 (3-4), 185-191 (1995)
   PUBMED   7842733
REFERENCE   10 (residues 1 to 452)
  AUTHORS   Ho AM, Jain J, Rao A and Hogan PG.
  TITLE     Expression of the transcription factor NFATp in a neuronal cell
            line and in the murine nervous system
  JOURNAL   J Biol Chem 269 (45), 28181-28186 (1994)
   PUBMED   7961754
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK044489.1, EU887601.1 and AW049827.1.
            
            Transcript Variant: This variant (3, also known as IA-IIS-VIIa)
            contains alternate 5' and 3' exon structure, and it thus differs in
            both UTRs, initiates translation at a downstream in-frame start
            codon, and differs in the 3' coding region, compared to variant 1.
            The encoded isoform (c) is shorter at the N-terminus and has a
            distinct C-terminus, compared to isoform a. Both variants 3 and 16
            encode isoform c.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU887601.1, AK083119.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..452
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 88.91 cM"
     Protein         1..452
                     /product="nuclear factor of activated T-cells, cytoplasmic
                     2 isoform c"
                     /note="nuclear factor of activated T-cells, cytoplasmic 2;
                     NFAT pre-existing subunit; T-cell transcription factor
                     NFAT1"
                     /calculated_mol_wt=48777
     Region          179..353
                     /region_name="RHD-n_NFAT"
                     /note="N-terminal sub-domain of the Rel homology domain
                     (RHD) of nuclear factor of activated T-cells (NFAT)
                     proteins; cd07881"
                     /db_xref="CDD:143641"
     Site            order(202,205,207..208,210..212,260,301,303..304,318..319,
                     321,352)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143641"
     Region          358..>397
                     /region_name="IPT"
                     /note="Immunoglobulin-like fold, Plexins, Transcription
                     factors (IPT). IPTs are also known as Transcription factor
                     ImmunoGlobin (TIG) domains. They are present in
                     intracellular transcription factors, cell surface
                     receptors (such as plexins and scatter factor...; cl15674"
                     /db_xref="CDD:449574"
     CDS             1..452
                     /gene="Nfatc2"
                     /gene_synonym="NF-ATc2; NF-ATp; NFAT1; NFAT1-D; Nfatp"
                     /coded_by="NM_001037178.2:203..1561"
                     /note="isoform c is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS17114.1"
                     /db_xref="GeneID:18019"
                     /db_xref="MGI:MGI:102463"
ORIGIN      
        1 msprtslaed sclgrhspvp rpasrssspg akrrhscaea lvaplpaasp qrsrspspqp
       61 sphvalqdds ipagypptag savlmdalnt latdspcgip skiwktspdp tpvstapska
      121 glarhiyptv eflgpceqee rrnsapesil lvpptwpkql vpaipicsip vtaslpplew
      181 plsnqsgsye lrievqpkph hrahyetegs rgavkaptgg hpvvqlhgym enkplglqif
      241 igtaderilk phafyqvhri tgktvtttsy ekivgntkvl eiplepknnm ratidcagil
      301 klrnadielr kgetdigrkn trvrlvfrvh vpepsgrivs lqaasnpiec sqrsahelpm
      361 verqdmdscl vyggqqmilt gqnftaeskv vfmekttgpa gtcetrplpi slisadrlsp
      421 wlsrlqrnpp gsvfrcsvll papgsslvll al
//
LOCUS       NP_001271274            1164 aa            linear   ROD 09-OCT-2023
DEFINITION  phospholipid-transporting ATPase IA isoform c [Mus musculus].
ACCESSION   NP_001271274
VERSION     NP_001271274.1
DBSOURCE    REFSEQ: accession NM_001284345.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1164)
  AUTHORS   Xu H, Oses-Prieto JA, Khvotchev M, Jain S, Liang J, Burlingame A
            and Edwards RH.
  TITLE     Adaptor protein AP-3 produces synaptic vesicles that release at
            high frequency by recruiting phospholipid flippase ATP8A1
  JOURNAL   Nat Neurosci 26 (10), 1685-1700 (2023)
   PUBMED   37723322
  REMARK    GeneRIF: Adaptor protein AP-3 produces synaptic vesicles that
            release at high frequency by recruiting phospholipid flippase
            ATP8A1.
REFERENCE   2  (residues 1 to 1164)
  AUTHORS   Zheng L, Pan C, Tian W, Liang C, Feng Y, He W, Yang Z, Wang B, Qiu
            Q, Li N, Sun Y, Qiu H, Sample KM, Zhou L, Zhu X and Hu Y.
  TITLE     Atp8a1 deletion increases the proliferative activity of
            hematopoietic stem cells by impairing PTEN function
  JOURNAL   Cell Oncol (Dordr) 46 (4), 1069-1083 (2023)
   PUBMED   36930333
  REMARK    GeneRIF: Atp8a1 deletion increases the proliferative activity of
            hematopoietic stem cells by impairing PTEN function.
REFERENCE   3  (residues 1 to 1164)
  AUTHORS   Kook S, Wang P, Meng S, Jetter CS, Sucre JMS, Benjamin JT, Gokey
            JJ, Hanby HA, Jaume A, Goetzl L, Marks MS and Guttentag SH.
  TITLE     AP-3-dependent targeting of flippase ATP8A1 to lamellar bodies
            suppresses activation of YAP in alveolar epithelial type 2 cells
  JOURNAL   Proc Natl Acad Sci U S A 118 (20) (2021)
   PUBMED   33990468
REFERENCE   4  (residues 1 to 1164)
  AUTHORS   Yap YT, Li YH, Li W, Banerjee P and Zhang Z.
  TITLE     ATP8a1, an IFT27 binding partner, is dispensable for
            spermatogenesis and male fertility
  JOURNAL   Mol Reprod Dev 88 (5), 371-375 (2021)
   PUBMED   33821543
  REMARK    GeneRIF: ATP8a1, an IFT27 binding partner, is dispensable for
            spermatogenesis and male fertility.
REFERENCE   5  (residues 1 to 1164)
  AUTHORS   Jing W, Yabas M, Broer A, Coupland L, Gardiner EE, Enders A and
            Broer S.
  TITLE     Calpain cleaves phospholipid flippase ATP8A1 during apoptosis in
            platelets
  JOURNAL   Blood Adv 3 (3), 219-229 (2019)
   PUBMED   30674456
  REMARK    GeneRIF: ATP8A1 is cleaved by the cysteine protease calpain during
            apoptosis, and the cleavage is prevented indirectly by caspase
            inhibition, involving blockage of calcium influx into platelets and
            subsequent calpain activation.
REFERENCE   6  (residues 1 to 1164)
  AUTHORS   Wang L, Beserra C and Garbers DL.
  TITLE     A novel aminophospholipid transporter exclusively expressed in
            spermatozoa is required for membrane lipid asymmetry and normal
            fertilization
  JOURNAL   Dev Biol 267 (1), 203-215 (2004)
   PUBMED   14975727
  REMARK    GeneRIF: role in normal phospholipid distribution in the bilayer,
            and for normal binding, penetration, and signaling by the zona
            pellucida
REFERENCE   7  (residues 1 to 1164)
  AUTHORS   Ding J, Wu Z, Crider BP, Ma Y, Li X, Slaughter C, Gong L and Xie
            XS.
  TITLE     Identification and functional expression of four isoforms of ATPase
            II, the putative aminophospholipid translocase. Effect of isoform
            variation on the ATPase activity and phospholipid specificity
  JOURNAL   J Biol Chem 275 (30), 23378-23386 (2000)
   PUBMED   10801890
REFERENCE   8  (residues 1 to 1164)
  AUTHORS   Wang Y, Saigoh K, Osaka H, Yamanishi T, Suh J, Kiyosawa H, Sakai Y,
            Wakana S and Wada K.
  TITLE     YAC/BAC-based physical and transcript mapping around the gracile
            axonal dystrophy (gad) locus identifies Uchl1, Pmx2b, Atp3a2, and
            Hip2 genes
  JOURNAL   Genomics 66 (3), 333-336 (2000)
   PUBMED   10873389
REFERENCE   9  (residues 1 to 1164)
  AUTHORS   Halleck MS, Lawler JF JR, Blackshaw S, Gao L, Nagarajan P, Hacker
            C, Pyle S, Newman JT, Nakanishi Y, Ando H, Weinstock D, Williamson
            P and Schlegel RA.
  TITLE     Differential expression of putative transbilayer amphipath
            transporters
  JOURNAL   Physiol Genomics 1 (3), 139-150 (1999)
   PUBMED   11015572
  REMARK    Publication Status: Online-Only
REFERENCE   10 (residues 1 to 1164)
  AUTHORS   Halleck MS, Pradhan D, Blackman C, Berkes C, Williamson P and
            Schlegel RA.
  TITLE     Multiple members of a third subfamily of P-type ATPases identified
            by genomic sequences and ESTs
  JOURNAL   Genome Res 8 (4), 354-361 (1998)
   PUBMED   9548971
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK151709.1, AK045367.1, AK141559.1, BC094235.1 and AC123662.13.
            
            Transcript Variant: This variant (3) lacks an alternate exon and
            contains a different alternate exon in the 5' coding region,
            compared to variant 1. It encodes isoform c, which is of the same
            size but lacks an internal segment, compared to isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC129872.1, SRR10662773.365692.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1164
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 36.15 cM"
     Protein         1..1164
                     /product="phospholipid-transporting ATPase IA isoform c"
                     /EC_number="7.6.2.1"
                     /note="probable phospholipid-transporting ATPase IA;
                     chromaffin granule ATPase II; ATPase class I type 8A
                     member 1; ATPase 8A1, p type; ATPase 8A1,
                     aminophospholipid transporter (APLT), class I; P4-ATPase
                     flippase complex alpha subunit ATP8A1; ATPase,
                     aminophospholipid transporter (APLT), class I, type 8A,
                     member 1"
                     /calculated_mol_wt=131378
     Site            25
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19144319,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P70704.2)"
     Site            28
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:19144319, ECO:0007744|PubMed:21183079;
                     propagated from UniProtKB/Swiss-Prot (P70704.2)"
     Site            29
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:19144319, ECO:0007744|PubMed:21183079;
                     propagated from UniProtKB/Swiss-Prot (P70704.2)"
     Region          49..1086
                     /region_name="ATPase-Plipid"
                     /note="phospholipid-translocating P-type ATPase, flippase;
                     TIGR01652"
                     /db_xref="CDD:273734"
     Site            76..96
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P70704.2)"
     Site            101..121
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P70704.2)"
     Site            139
                     /site_type="cleavage"
                     /note="Cleavage, by calpain.
                     /evidence=ECO:0000305|PubMed:30674456; propagated from
                     UniProtKB/Swiss-Prot (P70704.2)"
     Site            298..318
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P70704.2)"
     Site            340..360
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P70704.2)"
     Site            352
                     /site_type="other"
                     /note="Involved in the recognition of the lipid substrate
                     on the exoplasmic side.
                     /evidence=ECO:0000250|UniProtKB:C7EXK4; propagated from
                     UniProtKB/Swiss-Prot (P70704.2)"
     Site            357
                     /site_type="other"
                     /note="Involved in the release of the transported lipid
                     into the cytosolic leaflet.
                     /evidence=ECO:0000250|UniProtKB:C7EXK4; propagated from
                     UniProtKB/Swiss-Prot (P70704.2)"
     Site            443
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P70704.2)"
     Site            867..887
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P70704.2)"
     Site            891..911
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P70704.2)"
     Site            940..960
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P70704.2)"
     Site            978..998
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P70704.2)"
     Site            1009..1029
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P70704.2)"
     Site            1045..1065
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P70704.2)"
     Site            1126
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P70704.2)"
     CDS             1..1164
                     /gene="Atp8a1"
                     /gene_synonym="APLT; Atp3a2; B230107D19Rik; ClassI"
                     /coded_by="NM_001284345.1:222..3716"
                     /note="isoform c is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS80295.1"
                     /db_xref="GeneID:11980"
                     /db_xref="MGI:MGI:1330848"
ORIGIN      
        1 mptmrrtvse irsraegyek tddvsektsl adqeevrtif inqpqltkfc nnhvstakyn
       61 vitflprfly sqfrraansf flfiallqqi pdvsptgryt tlvpllfila vaaikeiied
      121 ikrhkadnav nkkqtqvlrn gaweivhwek vnvgdiviik gkeyipadtv llsssepqam
      181 cyietsnldg etnlkirqgl patsdikdid slmrisgrie cespnrhlyd fvgnirldgh
      241 gtvplgadqi llrgaqlrnt qwvhgivvyt ghdtklmqns tspplklsnv eritnvqili
      301 lfciliamsl vcsvgsaiwn rrhsgkdwyl hlhyggasnf glnfltfiil fnnlipisll
      361 vtlevvkftq ayfinwdldm hyeptdtaam artsnlneel gqvkyifsdk tgtltcnvmq
      421 fkkctiagva yghvpepedy gcspdewqss qfgdektfnd pslldnlqnn hptapiicef
      481 ltmmavchta vperegdkii yqaaspdega lvraakqlnf vftgrtpdsv iidslgqeer
      541 yellnvleft sarkrmsvvv rtpsgklrly ckgadtviye rlaetskyke itlkhleqfa
      601 teglrtlcfa vaeisesdfe ewravyhras tsvqnrllkl eesyeliekn lqllgataie
      661 dklqdqvpet ietlmkadik iwiltgdkqe tainighscr llkrnmgmiv inegsldgtr
      721 etlsrhcttl gdalrkendf aliidgktlk yaltfgvrqy fldlalscka viccrvsplq
      781 ksevvemvkk qvkvitlaig dgandvsmiq tahvgvgisg neglqaanss dysiaqfkyl
      841 knllmvhgaw nynrvskcil ycfyknivly iieiwfafvn gfsgqilfer wciglynvmf
      901 tamppltlgi ferscrkenm lkypelykts qnaldfntkv fwvhclnglf hsvilfwfpl
      961 kalqygtvfg ngktsdylll gnfvytfvvi tvclkaglet sywtwfshia iwgsialwvv
     1021 ffgiysslwp avpmapdmsg eaamlfssgv fwvgllsipv asllldvlyk vikrtafktl
     1081 vdevqeleak sqdpgavvlg kslteraqll knvfkknhvn lyrseslqqn llhgyafsqd
     1141 engivsqsev iraydttkqr pdew
//
LOCUS       NP_001349244             485 aa            linear   ROD 09-OCT-2023
DEFINITION  CUGBP Elav-like family member 4 isoform 35 [Mus musculus].
ACCESSION   NP_001349244
VERSION     NP_001349244.1
DBSOURCE    REFSEQ: accession NM_001362315.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 485)
  AUTHORS   Salamon I, Park Y, Miskic T, Kopic J, Matteson P, Page NF, Roque A,
            McAuliffe GW, Favate J, Garcia-Forn M, Shah P, Judas M, Millonig
            JH, Kostovic I, De Rubeis S, Hart RP, Krsnik Z and Rasin MR.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    GeneRIF: Celf4 controls mRNA translation underlying synaptic
            development in the prenatal mammalian neocortex.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 485)
  AUTHORS   Shen Y, Zhang C, Xiao K, Liu D and Xie G.
  TITLE     CELF4 regulates spine formation and depression-like behaviors of
            mice
  JOURNAL   Biochem Biophys Res Commun 605, 39-44 (2022)
   PUBMED   35306363
  REMARK    GeneRIF: CELF4 regulates spine formation and depression-like
            behaviors of mice.
REFERENCE   3  (residues 1 to 485)
  AUTHORS   Moreau MX, Saillour Y, Cwetsch AW, Pierani A and Causeret F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   4  (residues 1 to 485)
  AUTHORS   Li C, Li X, Bi Z, Sugino K, Wang G, Zhu T and Liu Z.
  TITLE     Comprehensive transcriptome analysis of cochlear spiral ganglion
            neurons at multiple ages
  JOURNAL   Elife 9, e50491 (2020)
   PUBMED   31913118
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 485)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 485)
  AUTHORS   Ladd AN, Taffet G, Hartley C, Kearney DL and Cooper TA.
  TITLE     Cardiac tissue-specific repression of CELF activity disrupts
            alternative splicing and causes cardiomyopathy
  JOURNAL   Mol Cell Biol 25 (14), 6267-6278 (2005)
   PUBMED   15988035
  REMARK    GeneRIF: CELF protein activity is required for normal alternative
            splicing in the heart in vivo and normal CELF-mediated alternative
            splicing regulation is in turn required for normal cardiac
            function.
REFERENCE   7  (residues 1 to 485)
  AUTHORS   Meins M, Schlickum S, Wilhelm C, Missbach J, Yadav S, Glaser B,
            Grzmil M, Burfeind P and Laccone F.
  TITLE     Identification and characterization of murine Brunol4, a new member
            of the elav/bruno family
  JOURNAL   Cytogenet Genome Res 97 (3-4), 254-260 (2002)
   PUBMED   12438720
  REMARK    GeneRIF: cloning and characterization
REFERENCE   8  (residues 1 to 485)
  AUTHORS   Ladd AN, Charlet N and Cooper TA.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   9  (residues 1 to 485)
  AUTHORS   Good PJ, Chen Q, Warner SJ and Herring DC.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
REFERENCE   10 (residues 1 to 485)
  AUTHORS   Yulug IG, Egan SE, See CG and Fisher EM.
  TITLE     Mapping GRB2, a signal transduction gene in the human and the mouse
  JOURNAL   Genomics 22 (2), 313-318 (1994)
   PUBMED   7806216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121094.8 and AC144938.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660821.93113.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 13.92 cM"
     Protein         1..485
                     /product="CUGBP Elav-like family member 4 isoform 35"
                     /note="CUG-BP- and ETR-3-like factor 4; bruno-like protein
                     4; RNA-binding protein BRUNOL-4; bruno-like 4, RNA binding
                     protein"
                     /calculated_mol_wt=51730
     Region          1..298
                     /region_name="Sufficient for RNA-binding and MSE-dependent
                     splicing activity. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          18..39
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          49..135
                     /region_name="RRM1_CELF3_4_5_6"
                     /note="RNA recognition motif 1 (RRM1) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12632"
                     /db_xref="CDD:410041"
     Site            order(55,57,59..60,63,82,84,86,95..97,99,129,131)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410041"
     Region          <56..378
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     Region          121..149
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          151..231
                     /region_name="RRM2_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12635"
                     /db_xref="CDD:410043"
     Site            order(153,155,157..158,161,180,182,184,192..194,196,226,
                     228)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410043"
     Region          239..258
                     /region_name="Necessary for TNNT2 exon 5 inclusion.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          416..474
                     /region_name="RRM_SF"
                     /note="RNA recognition motif (RRM) superfamily; cl17169"
                     /db_xref="CDD:450164"
     CDS             1..485
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /coded_by="NM_001362315.1:531..1988"
                     /note="isoform 35 is encoded by transcript variant 39"
                     /db_xref="CCDS:CCDS89205.1"
                     /db_xref="GeneID:108013"
                     /db_xref="MGI:MGI:1932407"
ORIGIN      
        1 myikmatlan gqadnaslst nglgsspgsa ghmnglshsp gnpstipmkd hdaiklfigq
       61 iprnldekdl kplfeefgki yeltvlkdrf tgmhkgcafl tyceresalk aqsalheqkt
      121 lpgmnrpiqv kpadsesrgg ssclrqppsq drklfvgmln kqqseddvrr lfeafgniee
      181 ctilrgpdgn skgcafvkys shaeaqaain alhgsqtmpg assslvvkfa dtdkertmrr
      241 mqqmagqmgm fnpmaipfga ygayaqalmq qqaalmasva qggylnpmaa faaaqmqqma
      301 alnmnglaaa pmtptsggst ppgitapavp sipspigvng ftglppqang qpaaeavfan
      361 gihpypaqsp taadplqqay agvqqyagpa ypaaygqisq afpqpppmip qqqregpegc
      421 nlliyhlpqe fgdaelmqmf lpfgfvsfdn pasaqtaiqa mngfqigmkr lkvqlkrpkd
      481 anrpy
//
LOCUS       NP_001392990             141 aa            linear   ROD 09-OCT-2023
DEFINITION  bcl-2-like protein 11 isoform 7 [Mus musculus].
ACCESSION   NP_001392990
VERSION     NP_001392990.1
DBSOURCE    REFSEQ: accession NM_001406061.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 141)
  AUTHORS   Jiang M, Wang XB and Jiang S.
  TITLE     circ_0000018 downregulation peripherally ameliorates
            neuroprotection against acute ischemic stroke through the
            miR-871/BCL2L11 axis
  JOURNAL   Mol Med Rep 28 (5) (2023)
   PUBMED   37772397
  REMARK    GeneRIF: circ_0000018 downregulation peripherally ameliorates
            neuroprotection against acute ischemic stroke through the
            miR-871/BCL2L11 axis.
REFERENCE   2  (residues 1 to 141)
  AUTHORS   Lu Y, Tang K, Wang S, Tian Z, Fan Y, Li B, Wang M, Zhao J and Xie
            J.
  TITLE     Dach1 deficiency drives alveolar epithelium apoptosis in pulmonary
            fibrosis via modulating C-Jun/Bim activity
  JOURNAL   Transl Res 257, 54-65 (2023)
   PUBMED   36754276
  REMARK    GeneRIF: Dach1 deficiency drives alveolar epithelium apoptosis in
            pulmonary fibrosis via modulating C-Jun/Bim activity.
REFERENCE   3  (residues 1 to 141)
  AUTHORS   Nguyen HV, Vandenberg CJ, Robati MR, Ng AP and Cory S.
  TITLE     MNT suppresses T cell apoptosis via BIM and is critical for T
            lymphomagenesis
  JOURNAL   Cell Death Differ 30 (4), 1018-1032 (2023)
   PUBMED   36755068
  REMARK    GeneRIF: MNT suppresses T cell apoptosis via BIM and is critical
            for T lymphomagenesis.
REFERENCE   4  (residues 1 to 141)
  AUTHORS   Chen H, Bai Y, Kobayashi M, Xiao S, Cai W, Barajas S, Chen S, Miao
            J, Meke FN, Vemula S, Ropa JP, Croop JM, Boswell HS, Wan J, Jia Y,
            Liu H, Li LS, Altman JK, Eklund EA, Ji P, Tong W, Band H, Huang DT,
            Platanias LC, Zhang ZY and Liu Y.
  TITLE     PRL2 phosphatase enhances oncogenic FLT3 signaling via
            dephosphorylation of the E3 ubiquitin ligase CBL at tyrosine 371
  JOURNAL   Blood 141 (3), 244-259 (2023)
   PUBMED   36206490
REFERENCE   5  (residues 1 to 141)
  AUTHORS   Brahma MK, Xiao P, Popa M, Negueruela J, Vandenbempt V, Demine S,
            Cardozo AK and Gurzov EN.
  TITLE     Nova1 or Bim Deficiency in Pancreatic beta-Cells Does Not Alter
            Multiple Low-Dose Streptozotocin-Induced Diabetes and Diet-Induced
            Obesity in Mice
  JOURNAL   Nutrients 14 (18), 3866 (2022)
   PUBMED   36145242
  REMARK    GeneRIF: Nova1 or Bim Deficiency in Pancreatic beta-Cells Does Not
            Alter Multiple Low-Dose Streptozotocin-Induced Diabetes and
            Diet-Induced Obesity in Mice.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 141)
  AUTHORS   Bouillet P, Zhang LC, Huang DC, Webb GC, Bottema CD, Shore P, Eyre
            HJ, Sutherland GR and Adams JM.
  TITLE     Gene structure alternative splicing, and chromosomal localization
            of pro-apoptotic Bcl-2 relative Bim
  JOURNAL   Mamm Genome 12 (2), 163-168 (2001)
   PUBMED   11210187
REFERENCE   7  (residues 1 to 141)
  AUTHORS   Bouillet P, Metcalf D, Huang DC, Tarlinton DM, Kay TW, Kontgen F,
            Adams JM and Strasser A.
  TITLE     Proapoptotic Bcl-2 relative Bim required for certain apoptotic
            responses, leukocyte homeostasis, and to preclude autoimmunity
  JOURNAL   Science 286 (5445), 1735-1738 (1999)
   PUBMED   10576740
REFERENCE   8  (residues 1 to 141)
  AUTHORS   Puthalakath H, Huang DC, O'Reilly LA, King SM and Strasser A.
  TITLE     The proapoptotic activity of the Bcl-2 family member Bim is
            regulated by interaction with the dynein motor complex
  JOURNAL   Mol Cell 3 (3), 287-296 (1999)
   PUBMED   10198631
REFERENCE   9  (residues 1 to 141)
  AUTHORS   Reed JC.
  TITLE     Bcl-2 family proteins
  JOURNAL   Oncogene 17 (25), 3225-3236 (1998)
   PUBMED   9916985
  REMARK    Review article
REFERENCE   10 (residues 1 to 141)
  AUTHORS   O'Connor L, Strasser A, O'Reilly LA, Hausmann G, Adams JM, Cory S
            and Huang DC.
  TITLE     Bim: a novel member of the Bcl-2 family that promotes apoptosis
  JOURNAL   EMBO J 17 (2), 384-395 (1998)
   PUBMED   9430630
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL805950.11.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR12282455.9073958.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..141
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 62.23 cM"
     Protein         1..141
                     /product="bcl-2-like protein 11 isoform 7"
                     /note="bcl-2-like protein 11; bcl2-interacting mediator of
                     cell death; Bcl2 interacting mediator of cell death;
                     BCL2-like 11 (apoptosis facilitator)"
                     /calculated_mol_wt=16145
     Region          4..40
                     /region_name="Bim_N"
                     /note="Bim protein N-terminus; pfam06773"
                     /db_xref="CDD:429111"
     Region          74..109
                     /region_name="Bclx_interact"
                     /note="Bcl-x interacting, BH3 domain; pfam08945"
                     /db_xref="CDD:430337"
     CDS             1..141
                     /gene="Bcl2l11"
                     /gene_synonym="1500006F24Rik; bcl2-L-11; Bim; Bod"
                     /coded_by="NM_001406061.1:229..654"
                     /note="isoform 7 is encoded by transcript variant 10"
                     /db_xref="GeneID:12125"
                     /db_xref="MGI:MGI:1197519"
ORIGIN      
        1 makqpsdvss ecdreggqlq paerppqlrp gaptslqtep qdrspapmsc dkstqtpspp
       61 cqafnhylsa maasirqsqe epedlrpeir iaqelrrigd efnetytrrv fandyreaed
      121 hpqmvilqll rfifrlvwrr h
//
LOCUS       NP_038695                553 aa            linear   ROD 09-OCT-2023
DEFINITION  solute carrier family 22 member 2 isoform 1 [Mus musculus].
ACCESSION   NP_038695
VERSION     NP_038695.1
DBSOURCE    REFSEQ: accession NM_013667.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 553)
  AUTHORS   Orrico-Sanchez A, Guiard BP, Manta S, Callebert J, Launay JM, Louis
            F, Paccard A, Gruszczynski C, Betancur C, Vialou V and Gautron S.
  TITLE     Organic cation transporter 2 contributes to SSRI antidepressant
            efficacy by controlling tryptophan availability in the brain
  JOURNAL   Transl Psychiatry 13 (1), 302 (2023)
   PUBMED   37775532
  REMARK    GeneRIF: Organic cation transporter 2 contributes to SSRI
            antidepressant efficacy by controlling tryptophan availability in
            the brain.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 553)
  AUTHORS   Hucke A, Schroter R, Ceresa C, Chiorazzi A, Canta A, Semperboni S,
            Marmiroli P, Cavaletti G, Gess B and Ciarimboli G.
  TITLE     Role of Mouse Organic Cation Transporter 2 for Nephro- and
            Peripheral Neurotoxicity Induced by Chemotherapeutic Treatment with
            Cisplatin
  JOURNAL   Int J Mol Sci 24 (14), 11486 (2023)
   PUBMED   37511245
  REMARK    GeneRIF: Role of Mouse Organic Cation Transporter 2 for Nephro- and
            Peripheral Neurotoxicity Induced by Chemotherapeutic Treatment with
            Cisplatin.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 553)
  AUTHORS   La Manno G, Siletti K, Furlan A, Gyllborg D, Vinsland E, Mossi
            Albiach A, Mattsson Langseth C, Khven I, Lederer AR, Dratva LM,
            Johnsson A, Nilsson M, Lonnerberg P and Linnarsson S.
  TITLE     Molecular architecture of the developing mouse brain
  JOURNAL   Nature 596 (7870), 92-96 (2021)
   PUBMED   34321664
REFERENCE   4  (residues 1 to 553)
  AUTHORS   Martinez ME and Hernandez A.
  TITLE     The Type 3 Deiodinase Is a Critical Modulator of Thyroid Hormone
            Sensitivity in the Fetal Brain
  JOURNAL   Front Neurosci 15, 703730 (2021)
   PUBMED   34248495
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 553)
  AUTHORS   Morse BL, Chen LH, Catlow JT, Fallon JK, Smith PC and Hillgren KM.
  TITLE     Expansion of Knowledge on OCT1 Variant Activity In Vitro and In
            Vivo Using Oct1/2-/- Mice
  JOURNAL   Front Pharmacol 12, 631793 (2021)
   PUBMED   33658943
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 553)
  AUTHORS   Sleutels F, Zwart R and Barlow DP.
  TITLE     The non-coding Air RNA is required for silencing autosomal
            imprinted genes
  JOURNAL   Nature 415 (6873), 810-813 (2002)
   PUBMED   11845212
  REMARK    GeneRIF: Slc22a2 is one of three imprinted genes on chromosome 17
            that is expressed from the maternal allele. A non-coding Air RNA is
            required for repression of all three genes on the paternal allele.
REFERENCE   7  (residues 1 to 553)
  AUTHORS   Vallette-Kasic S, Pellegrini-Bouiller I, Sampieri F, Gunz G, Diaz
            A, Radovick S, Enjalbert A and Brue T.
  TITLE     Combined pituitary hormone deficiency due to the F135C human Pit-1
            (pituitary-specific factor 1) gene mutation: functional and
            structural correlates
  JOURNAL   Mol Endocrinol 15 (3), 411-420 (2001)
   PUBMED   11222742
REFERENCE   8  (residues 1 to 553)
  AUTHORS   Mooslehner KA and Allen ND.
  TITLE     Cloning of the mouse organic cation transporter 2 gene, Slc22a2,
            from an enhancer-trap transgene integration locus
  JOURNAL   Mamm Genome 10 (3), 218-224 (1999)
   PUBMED   10051314
REFERENCE   9  (residues 1 to 553)
  AUTHORS   Verhaagh S, Schweifer N, Barlow DP and Zwart R.
  TITLE     Cloning of the mouse and human solute carrier 22a3
            (Slc22a3/SLC22A3) identifies a conserved cluster of three organic
            cation transporters on mouse chromosome 17 and human 6q26-q27
  JOURNAL   Genomics 55 (2), 209-218 (1999)
   PUBMED   9933568
REFERENCE   10 (residues 1 to 553)
  AUTHORS   Koehler MR, Wissinger B, Gorboulev V, Koepsell H and Schmid M.
  TITLE     The two human organic cation transporter genes SLC22A1 and SLC22A2
            are located on chromosome 6q26
  JOURNAL   Cytogenet Cell Genet 79 (3-4), 198-200 (1997)
   PUBMED   9605850
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC167817.4, AK143892.1, AK052658.1 and BB739804.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC069911.1, AK143892.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            imprinted gene         :: PMID: 11845212
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..553
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 8.61 cM"
     Protein         1..553
                     /product="solute carrier family 22 member 2 isoform 1"
                     /note="organic cation transporter 2; solute carrier family
                     22 member 2"
                     /calculated_mol_wt=61700
     Region          12..525
                     /region_name="2A0119"
                     /note="cation transport protein; TIGR00898"
                     /db_xref="CDD:273328"
     Site            22..42
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O70577.1)"
     Site            71
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O70577.1)"
     Site            151..171
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O70577.1)"
     Site            178..198
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O70577.1)"
     Site            211..231
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O70577.1)"
     Site            239..259
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O70577.1)"
     Site            264..284
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O70577.1)"
     Region          284..288
                     /region_name="Proline-rich sequence.
                     /evidence=ECO:0000250|UniProtKB:O15244"
                     /note="propagated from UniProtKB/Swiss-Prot (O70577.1)"
     Site            349..369
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O70577.1)"
     Site            376..396
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O70577.1)"
     Site            405..425
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O70577.1)"
     Site            433..453
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O70577.1)"
     Site            451
                     /site_type="other"
                     /note="Involved in recognition of organic cations and
                     participates in structural changes that occur during
                     translocation of organic cations.
                     /evidence=ECO:0000250|UniProtKB:Q9R0W2; propagated from
                     UniProtKB/Swiss-Prot (O70577.1)"
     Site            465..485
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O70577.1)"
     Site            495..515
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O70577.1)"
     CDS             1..553
                     /gene="Slc22a2"
                     /gene_synonym="mOCT2; Oct2; Orct2"
                     /coded_by="NM_013667.3:93..1754"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS28392.1"
                     /db_xref="GeneID:20518"
                     /db_xref="MGI:MGI:1335072"
ORIGIN      
        1 mptvddileh igefhlfqkq tffllallsg aftpiyvgiv flgftpnhhc rspgvaelsq
       61 rcgwspaeel nytvpglgsa gevsflsqcm ryevdwnqst ldcvdplssl aanrshlpls
      121 pcehgwvydt pgssivtefn lvcahswmld lfqslvnvgf figavgigyl adrfgrkfcl
      181 lvtilinais gvlmaispny awmlvfrflq glvskagwli gyilitefvg lgyrrtvgic
      241 yqiaftvgll ilagvayalp nwrwlqfavt lpnfcfllyf wcipesprwl isqnknakam
      301 kiikhiakkn gksvpvslqs ltadedtgmk lnpsfldlvr tpqirkhtli lmynwftssv
      361 lyqglimhmg lagdniyldf fysalvefpa afiiiltidr igrrypwavs nmvagaacla
      421 svfipddlqw lkitvaclgr mgitiayemv clvnaelypt yirnlavlvc ssmcdiggiv
      481 tpflvyrltd iwlefplvvf avvglvaggl vlllpetkgk alpetiedae kmqrprkkke
      541 kriylqvkka els
//
LOCUS       NP_001157174             280 aa            linear   ROD 09-OCT-2023
DEFINITION  F-box only protein 27 isoform 1 [Mus musculus].
ACCESSION   NP_001157174
VERSION     NP_001157174.1
DBSOURCE    REFSEQ: accession NM_001163702.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 280)
  AUTHORS   Liu D, Xing R, Zhang Q, Tian X, Qi Y, Song H, Liu Y, Yu H, Zhang X,
            Jing Q, Yan C and Han Y.
  TITLE     The CREG1-FBXO27-LAMP2 axis alleviates diabetic cardiomyopathy by
            promoting autophagy in cardiomyocytes
  JOURNAL   Exp Mol Med 55 (9), 2025-2038 (2023)
   PUBMED   37658156
  REMARK    GeneRIF: The CREG1-FBXO27-LAMP2 axis alleviates diabetic
            cardiomyopathy by promoting autophagy in cardiomyocytes.
REFERENCE   2  (residues 1 to 280)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK158463.1 and BQ033399.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC075656.1, AK158463.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..280
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 16.89 cM"
     Protein         1..280
                     /product="F-box only protein 27 isoform 1"
                     /note="F-box only protein 27"
                     /calculated_mol_wt=31502
     Region          <37..70
                     /region_name="F-box_SF"
                     /note="F-box domain superfamily; cl45894"
                     /db_xref="CDD:459239"
     Region          102..275
                     /region_name="FBA"
                     /note="F-box associated region; pfam04300"
                     /db_xref="CDD:427850"
     CDS             1..280
                     /gene="Fbxo27"
                     /gene_synonym="E130008B10Rik; FBG5; Gm161"
                     /coded_by="NM_001163702.1:153..995"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS52164.1"
                     /db_xref="GeneID:233040"
                     /db_xref="MGI:MGI:2685007"
ORIGIN      
        1 mgawisrtrv ptpepdpqev ldlsrlppel lllvlshvpp rtllmhcrrv crawralvdg
       61 qalwllllar dhsaagrall tlarrclppa hedtpcplgq fcalrplgrn lisnpcgqeg
      121 lrkwmvrhgg dgwvveknrk pvpgapsqtc fvtsfswcrk kqvvdlvekg lwpelldsgg
      181 veiavsdwwg arhdsgckyr lfvtlldahq nvidkfsavp dpieqwnndi ylqvthvfsg
      241 irrgirfvsf ehwgqdtqfw aghygarvtn ssviirvcqs
//
LOCUS       NP_659137                503 aa            linear   ROD 09-OCT-2023
DEFINITION  mitochondrial antiviral-signaling protein isoform 1 [Mus musculus].
ACCESSION   NP_659137
VERSION     NP_659137.1
DBSOURCE    REFSEQ: accession NM_144888.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 503)
  AUTHORS   Liu F, Zhuang W, Song B, Yang Y, Liu J, Zheng Y, Liu B, Zheng J,
            Zhao W and Gao C.
  TITLE     MAVS-loaded unanchored Lys63-linked polyubiquitin chains activate
            the RIG-I-MAVS signaling cascade
  JOURNAL   Cell Mol Immunol 20 (10), 1186-1202 (2023)
   PUBMED   37582970
  REMARK    GeneRIF: MAVS-loaded unanchored Lys63-linked polyubiquitin chains
            activate the RIG-I-MAVS signaling cascade.
REFERENCE   2  (residues 1 to 503)
  AUTHORS   Ingle H, Makimaa H, Aggarwal S, Deng H, Foster L, Li Y, Kennedy EA,
            Peterson ST, Wilen CB, Lee S, Suthar MS and Baldridge MT.
  TITLE     IFN-lambda derived from nonsusceptible enterocytes acts on tuft
            cells to limit persistent norovirus
  JOURNAL   Sci Adv 9 (37), eadi2562 (2023)
   PUBMED   37703370
REFERENCE   3  (residues 1 to 503)
  AUTHORS   He QQ, Huang Y, Nie L, Ren S, Xu G, Deng F, Cheng Z, Zuo Q, Zhang
            L, Cai H, Wang Q, Wang F, Ren H, Yan H, Xu K, Zhou L, Lu M, Lu Z,
            Zhu Y and Liu S.
  TITLE     MAVS integrates glucose metabolism and RIG-I-like receptor
            signaling
  JOURNAL   Nat Commun 14 (1), 5343 (2023)
   PUBMED   37660168
  REMARK    GeneRIF: MAVS integrates glucose metabolism and RIG-I-like receptor
            signaling.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 503)
  AUTHORS   Li J, Zhang R, Wang C, Zhu J, Ren M, Jiang Y, Hou X, Du Y, Wu Q, Qi
            S, Li L, Chen S, Yang H and Hou F.
  TITLE     WDR77 inhibits prion-like aggregation of MAVS to limit antiviral
            innate immune response
  JOURNAL   Nat Commun 14 (1), 4824 (2023)
   PUBMED   37563140
  REMARK    GeneRIF: WDR77 inhibits prion-like aggregation of MAVS to limit
            antiviral innate immune response.
            Erratum:[Nat Commun. 2023 Sep 25;14(1):5960. PMID: 37749076]
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 503)
  AUTHORS   Wang H, Sun W, Traba J, Wu J, Qi CF, Amo L, Kole HK, Scott B, Singh
            K, Sack MN and Bolland S.
  TITLE     MAVS Positively Regulates Mitochondrial Integrity and Metabolic
            Fitness in B Cells
  JOURNAL   Immunohorizons 7 (8), 587-599 (2023)
   PUBMED   37610299
  REMARK    GeneRIF: MAVS Positively Regulates Mitochondrial Integrity and
            Metabolic Fitness in B Cells.
REFERENCE   6  (residues 1 to 503)
  AUTHORS   Kumar H, Kawai T, Kato H, Sato S, Takahashi K, Coban C, Yamamoto M,
            Uematsu S, Ishii KJ, Takeuchi O and Akira S.
  TITLE     Essential role of IPS-1 in innate immune responses against RNA
            viruses
  JOURNAL   J Exp Med 203 (7), 1795-1803 (2006)
   PUBMED   16785313
  REMARK    GeneRIF: IPS-1 is the sole adapter in both retinoic acid-inducible
            gene (RIG-I) and melanoma differentiation-associated gene 5 (Mda5)
            signaling that mediates effective responses against a variety of
            RNA viruses.
REFERENCE   7  (residues 1 to 503)
  AUTHORS   Sun Q, Sun L, Liu HH, Chen X, Seth RB, Forman J and Chen ZJ.
  TITLE     The specific and essential role of MAVS in antiviral innate immune
            responses
  JOURNAL   Immunity 24 (5), 633-642 (2006)
   PUBMED   16713980
REFERENCE   8  (residues 1 to 503)
  AUTHORS   Meylan E, Curran J, Hofmann K, Moradpour D, Binder M,
            Bartenschlager R and Tschopp J.
  TITLE     Cardif is an adaptor protein in the RIG-I antiviral pathway and is
            targeted by hepatitis C virus
  JOURNAL   Nature 437 (7062), 1167-1172 (2005)
   PUBMED   16177806
REFERENCE   9  (residues 1 to 503)
  AUTHORS   Xu LG, Wang YY, Han KJ, Li LY, Zhai Z and Shu HB.
  TITLE     VISA is an adapter protein required for virus-triggered IFN-beta
            signaling
  JOURNAL   Mol Cell 19 (6), 727-740 (2005)
   PUBMED   16153868
  REMARK    GeneRIF: Data suggest that VISA is critically involved in both
            virus-triggered TLR3-independent and TLR3-mediated antiviral
            interferon signaling.
REFERENCE   10 (residues 1 to 503)
  AUTHORS   Seth RB, Sun L, Ea CK and Chen ZJ.
  TITLE     Identification and characterization of MAVS, a mitochondrial
            antiviral signaling protein that activates NF-kappaB and IRF 3
  JOURNAL   Cell 122 (5), 669-682 (2005)
   PUBMED   16125763
  REMARK    GeneRIF: The overexpression of mitochondrial antiviral
            signaling(MAVS)induces the expression of IFN-beta through
            activation of NF-kappaB and IRF 3, thus boosting antiviral
            immunity.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL808128.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1). Variants 1 and 2
            encode the same isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC025825.1, AK085038.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: PMID: 16125763; reported by
                                                  MitoCarta
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 63.3 cM"
     Protein         1..503
                     /product="mitochondrial antiviral-signaling protein
                     isoform 1"
                     /note="IFN-beta promoter stimulator-1; mitochondrial
                     anti-viral signaling protein; virus-induced signaling
                     adapter; CARD adapter inducing interferon beta; interferon
                     beta promoter stimulator protein 1"
                     /calculated_mol_wt=53268
     Region          3..93
                     /region_name="CARD_IPS1"
                     /note="Caspase activation and recruitment domain (CARD)
                     found in IPS-1; cd08811"
                     /db_xref="CDD:260073"
     Region          10..77
                     /region_name="Required for interaction with NLRX1.
                     /evidence=ECO:0000250|UniProtKB:Q7Z434"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCF0.1)"
     Region          119..202
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCF0.1)"
     Region          143..147
                     /region_name="Interaction with TRAF2.
                     /evidence=ECO:0000250|UniProtKB:Q7Z434"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCF0.1)"
     Site            152
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8VCF0.1)"
     Region          153..158
                     /region_name="Interaction with TRAF6 1.
                     /evidence=ECO:0000250|UniProtKB:Q7Z434"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCF0.1)"
     Site            157
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q7Z434; propagated from
                     UniProtKB/Swiss-Prot (Q8VCF0.1)"
     Site            172
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8VCF0.1)"
     Site            186
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q7Z434; propagated from
                     UniProtKB/Swiss-Prot (Q8VCF0.1)"
     Site            220
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q7Z434; propagated from
                     UniProtKB/Swiss-Prot (Q8VCF0.1)"
     Site            234
                     /site_type="methylation"
                     /note="Asymmetric dimethylarginine.
                     /evidence=ECO:0007744|PubMed:24129315; propagated from
                     UniProtKB/Swiss-Prot (Q8VCF0.1)"
     Site            251
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q7Z434; propagated from
                     UniProtKB/Swiss-Prot (Q8VCF0.1)"
     Site            256
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q7Z434; propagated from
                     UniProtKB/Swiss-Prot (Q8VCF0.1)"
     Region          337..503
                     /region_name="Interaction with DHX33.
                     /evidence=ECO:0000269|PubMed:24037184"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCF0.1)"
     Region          346..398
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCF0.1)"
     Site            384
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8VCF0.1)"
     Site            405..406
                     /site_type="cleavage"
                     /note="Cleavage, by CASP3.
                     /evidence=ECO:0000250|UniProtKB:Q7Z434; propagated from
                     UniProtKB/Swiss-Prot (Q8VCF0.1)"
     Region          415..418
                     /region_name="pLxIS motif.
                     /evidence=ECO:0000250|UniProtKB:Q7Z434"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCF0.1)"
     Site            418
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by TBK1.
                     /evidence=ECO:0000250|UniProtKB:Q7Z434; propagated from
                     UniProtKB/Swiss-Prot (Q8VCF0.1)"
     Region          431..436
                     /region_name="Interaction with TRAF6 2.
                     /evidence=ECO:0000250|UniProtKB:Q7Z434"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCF0.1)"
     Region          446..466
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCF0.1)"
     Site            479..496
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCF0.1)"
     CDS             1..503
                     /gene="Mavs"
                     /gene_synonym="cardif; D430028G21Rik; IPS-1; Visa"
                     /coded_by="NM_144888.2:352..1863"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS16760.1"
                     /db_xref="GeneID:228607"
                     /db_xref="MGI:MGI:2444773"
ORIGIN      
        1 mtfaedktyk yirdnhskfc cvdvleilpy lscltasdqd rlrasyrqig nrdtlwglfn
       61 nlqrrpgwve vfiralqice lpgladqvtr vyqsylppgt slrsleplql pdfpaavsgp
      121 safapghnip dhglretpsc pkpvqdtqpp espvenseql lqtnsgavar msggslipsp
      181 nqqalspqps rehqeqepel ggahaanvas vpiatygpvs ptvsfqplpr talrtnllsg
      241 vtvsalsadt slsssstgsa fakgagdqak aatcfsttlt nsvttssvps prlvpvktms
      301 sklplsskst aamtstvltn tapsklpsns vyagtvpsrv pasvakapan tippernskq
      361 aketpegpat kvttggnqtg pnssirslhs gpemskpgvl vsqldepfsa csvdlaisps
      421 sslvsepnhg peeneyssfr iqvdespsad llgspeplat qqpqeeeehc assmpwakwl
      481 gatsallavf lavmlyrsrr laq
//
LOCUS       NP_067618                302 aa            linear   ROD 09-OCT-2023
DEFINITION  serine/threonine-protein kinase Nek7 isoform 1 [Mus musculus].
ACCESSION   NP_067618
VERSION     NP_067618.1
DBSOURCE    REFSEQ: accession NM_021605.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 302)
  AUTHORS   Park YJ, Dodantenna N, Kim Y, Kim TH, Lee HS, Yoo YS, Heo J, Lee
            JH, Kwon MH, Kang HC, Lee JS and Cho H.
  TITLE     MARCH5-dependent NLRP3 ubiquitination is required for mitochondrial
            NLRP3-NEK7 complex formation and NLRP3 inflammasome activation
  JOURNAL   EMBO J 42 (19), e113481 (2023)
   PUBMED   37575012
  REMARK    GeneRIF: MARCH5-dependent NLRP3 ubiquitination is required for
            mitochondrial NLRP3-NEK7 complex formation and NLRP3 inflammasome
            activation.
REFERENCE   2  (residues 1 to 302)
  AUTHORS   Sun W, Yue M, Xi G, Wang K and Sai J.
  TITLE     Knockdown of NEK7 alleviates anterior cruciate ligament transection
            osteoarthritis (ACLT)-induced knee osteoarthritis in mice via
            inhibiting NLRP3 activation
  JOURNAL   Autoimmunity 55 (6), 398-407 (2022)
   PUBMED   35798413
  REMARK    GeneRIF: Knockdown of NEK7 alleviates anterior cruciate ligament
            transection osteoarthritis (ACLT)-induced knee osteoarthritis in
            mice via inhibiting NLRP3 activation.
REFERENCE   3  (residues 1 to 302)
  AUTHORS   Zhang M, Zhi D, Lin J, Liu P, Wang Y and Duan M.
  TITLE     miR-181a-5p Inhibits Pyroptosis in Sepsis-Induced Acute Kidney
            Injury through Downregulation of NEK7
  JOURNAL   J Immunol Res 2022, 1825490 (2022)
   PUBMED   35991122
  REMARK    GeneRIF: miR-181a-5p Inhibits Pyroptosis in Sepsis-Induced Acute
            Kidney Injury through Downregulation of NEK7.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 302)
  AUTHORS   Wu G, Zhang D, Yang L, Wu Q and Yuan L.
  TITLE     MicroRNA-200c-5p targets NIMA Related Kinase 7 (NEK7) to inhibit
            NOD-like receptor 3 (NLRP3) inflammasome activation, MODE-K cell
            pyroptosis, and inflammatory bowel disease in mice
  JOURNAL   Mol Immunol 146, 57-68 (2022)
   PUBMED   35447415
  REMARK    GeneRIF: MicroRNA-200c-5p targets NIMA Related Kinase 7 (NEK7) to
            inhibit NOD-like receptor 3 (NLRP3) inflammasome activation, MODE-K
            cell pyroptosis, and inflammatory bowel disease in mice.
REFERENCE   5  (residues 1 to 302)
  AUTHORS   Jeltema D, Wang J, Cai J, Kelley N, Yang Z and He Y.
  TITLE     A Single Amino Acid Residue Defines the Difference in NLRP3
            Inflammasome Activation between NEK7 and NEK6
  JOURNAL   J Immunol 208 (8), 2029-2036 (2022)
   PUBMED   35354613
  REMARK    GeneRIF: A Single Amino Acid Residue Defines the Difference in
            NLRP3 Inflammasome Activation between NEK7 and NEK6.
REFERENCE   6  (residues 1 to 302)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (residues 1 to 302)
  AUTHORS   Morrish TA, Gilbert N, Myers JS, Vincent BJ, Stamato TD, Taccioli
            GE, Batzer MA and Moran JV.
  TITLE     DNA repair mediated by endonuclease-independent LINE-1
            retrotransposition
  JOURNAL   Nat Genet 31 (2), 159-165 (2002)
   PUBMED   12006980
REFERENCE   8  (residues 1 to 302)
  AUTHORS   Feige E and Motro B.
  TITLE     The related murine kinases, Nek6 and Nek7, display distinct
            patterns of expression
  JOURNAL   Mech Dev 110 (1-2), 219-223 (2002)
   PUBMED   11744387
  REMARK    GeneRIF: During early embryogenesis nek7 is expressed in the site
            of decidual reaction. Later in embryogenesis, nek7 is highly
            expressed in the dorsal thalamus.
REFERENCE   9  (residues 1 to 302)
  AUTHORS   Kimura M and Okano Y.
  TITLE     Identification and assignment of the human NIMA-related protein
            kinase 7 gene (NEK7) to human chromosome 1q31.3
  JOURNAL   Cytogenet Cell Genet 94 (1-2), 33-38 (2001)
   PUBMED   11701951
REFERENCE   10 (residues 1 to 302)
  AUTHORS   Kandli M, Feige E, Chen A, Kilfin G and Motro B.
  TITLE     Isolation and characterization of two evolutionarily conserved
            murine kinases (Nek6 and nek7) related to the fungal mitotic
            regulator, NIMA
  JOURNAL   Genomics 68 (2), 187-196 (2000)
   PUBMED   10964517
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC118216.15 and AC161436.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK149308.1, AK035502.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..302
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 60.82 cM"
     Protein         1..302
                     /product="serine/threonine-protein kinase Nek7 isoform 1"
                     /EC_number="2.7.11.34"
                     /note="NIMA-related kinase 7; serine/threonine-protein
                     kinase Nek7; nimA-related protein kinase 7; never in
                     mitosis A-related kinase 7; NIMA-related expressed kinase
                     7"
                     /calculated_mol_wt=34406
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:Q8TDX7; propagated from
                     UniProtKB/Swiss-Prot (Q9ES74.1)"
     Site            5
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8TDX7; propagated from
                     UniProtKB/Swiss-Prot (Q9ES74.1)"
     Region          20..33
                     /region_name="NTE motif.
                     /evidence=ECO:0000250|UniProtKB:Q8TDX7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ES74.1)"
     Region          33..294
                     /region_name="STKc_Nek6_7"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     Never In Mitosis gene A (NIMA)-related kinase 6 and 7;
                     cd08224"
                     /db_xref="CDD:270863"
     Site            order(40..44,48,61,63,95,111..114,118,120,161,163,
                     165..166,168,179,182,184,198..201)
                     /site_type="active"
                     /db_xref="CDD:270863"
     Site            order(40..41,43..44,48,61,63,95,112..114,118,166,168,184)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270863"
     Site            order(44,118,120,161,163,165,182,198..201)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270863"
     Site            97
                     /site_type="other"
                     /note="Autoinhibitory.
                     /evidence=ECO:0000250|UniProtKB:Q8TDX7; propagated from
                     UniProtKB/Swiss-Prot (Q9ES74.1)"
     Site            178..201
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270863"
     Site            195
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by NEK9.
                     /evidence=ECO:0000250|UniProtKB:Q8TDX7; propagated from
                     UniProtKB/Swiss-Prot (Q9ES74.1)"
     CDS             1..302
                     /gene="Nek7"
                     /gene_synonym="2810460C19Rik"
                     /coded_by="NM_021605.5:219..1127"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS15332.1"
                     /db_xref="GeneID:59125"
                     /db_xref="MGI:MGI:1890645"
ORIGIN      
        1 mdeqsqgmqg ppvtqfqpqk alrpdmgynt lanfriekki grgqfsevyr asclldgvpv
       61 alkkvqifdl mdakaradci keidllkqln hpnvikyyas fiednelniv leladagdls
      121 rmikhfkkqk rlipertvwk yfvqlcsald hmhsrrvmhr dikpanvfit atgvvklgdl
      181 glgrffsskt taahslvgtp yymsperihe ngynfksdiw slgcllyema alqspfygdk
      241 mnlyslckki eqcdypplps dhyseelrql vnicinpdpe krpdiayvyd vakrmhacta
      301 st
//
LOCUS       NP_001278100             473 aa            linear   ROD 09-OCT-2023
DEFINITION  nuclear factor of activated T-cells, cytoplasmic 2 isoform h [Mus
            musculus].
ACCESSION   NP_001278100
VERSION     NP_001278100.1
DBSOURCE    REFSEQ: accession NM_001291171.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 473)
  AUTHORS   Fu Y, Wang J, Liu C, Liao K, Gao X, Tang R, Fan B, Hong Y, Xiao N,
            Xiao C and Liu WH.
  TITLE     Glycogen synthase kinase 3 controls T-cell exhaustion by regulating
            NFAT activation
  JOURNAL   Cell Mol Immunol 20 (10), 1127-1139 (2023)
   PUBMED   37553428
  REMARK    GeneRIF: Glycogen synthase kinase 3 controls T-cell exhaustion by
            regulating NFAT activation.
REFERENCE   2  (residues 1 to 473)
  AUTHORS   Wan X, Zhao S, Dai Y, Zhang J, Shen Y, Gong L and Le Q.
  TITLE     WNT16b promotes the proliferation and self-renewal of human limbal
            epithelial stem/progenitor cells via activating the
            calcium/calcineurin A/NFATC2 pathway
  JOURNAL   Cell Prolif 56 (10), e13460 (2023)
   PUBMED   36974338
  REMARK    GeneRIF: WNT16b promotes the proliferation and self-renewal of
            human limbal epithelial stem/progenitor cells via activating the
            calcium/calcineurin A/NFATC2 pathway.
REFERENCE   3  (residues 1 to 473)
  AUTHORS   Jiang F, Guo Y, Hu L, Zhang M, Meng J, Si Y and Shi H.
  TITLE     Role of nuclear factor of activated T Cells-1 in Sepsis-induced
            behavioral deficits in mice
  JOURNAL   Brain Res 1806, 148299 (2023)
   PUBMED   36842570
REFERENCE   4  (residues 1 to 473)
  AUTHORS   Nagai J, Lin J and Boyce JA.
  TITLE     Macrophage P2Y6 Receptor Signaling Selectively Activates NFATC2 and
            Suppresses Allergic Lung Inflammation
  JOURNAL   J Immunol 209 (12), 2293-2303 (2022)
   PUBMED   36307120
  REMARK    GeneRIF: Macrophage P2Y6 Receptor Signaling Selectively Activates
            NFATC2 and Suppresses Allergic Lung Inflammation.
REFERENCE   5  (residues 1 to 473)
  AUTHORS   Zhu L, Zhou X, Gu M, Kim J, Li Y, Ko CJ, Xie X, Gao T, Cheng X and
            Sun SC.
  TITLE     Dapl1 controls NFATc2 activation to regulate CD8+ T cell exhaustion
            and responses in chronic infection and cancer
  JOURNAL   Nat Cell Biol 24 (7), 1165-1176 (2022)
   PUBMED   35773432
REFERENCE   6  (residues 1 to 473)
  AUTHORS   Vihma H, Pruunsild P and Timmusk T.
  TITLE     Alternative splicing and expression of human and mouse NFAT genes
  JOURNAL   Genomics 92 (5), 279-291 (2008)
   PUBMED   18675896
REFERENCE   7  (residues 1 to 473)
  AUTHORS   Ho SN, Thomas DJ, Timmerman LA, Li X, Francke U and Crabtree GR.
  TITLE     NFATc3, a lymphoid-specific NFATc family member that is
            calcium-regulated and exhibits distinct DNA binding specificity
  JOURNAL   J Biol Chem 270 (34), 19898-19907 (1995)
   PUBMED   7650004
REFERENCE   8  (residues 1 to 473)
  AUTHORS   Jain J, Burgeon E, Badalian TM, Hogan PG and Rao A.
  TITLE     A similar DNA-binding motif in NFAT family proteins and the Rel
            homology region
  JOURNAL   J Biol Chem 270 (8), 4138-4145 (1995)
   PUBMED   7876165
REFERENCE   9  (residues 1 to 473)
  AUTHORS   Li X, Ho SN, Luna J, Giacalone J, Thomas DJ, Timmerman LA, Crabtree
            GR and Francke U.
  TITLE     Cloning and chromosomal localization of the human and murine genes
            for the T-cell transcription factors NFATc and NFATp
  JOURNAL   Cytogenet Cell Genet 68 (3-4), 185-191 (1995)
   PUBMED   7842733
REFERENCE   10 (residues 1 to 473)
  AUTHORS   Ho AM, Jain J, Rao A and Hogan PG.
  TITLE     Expression of the transcription factor NFATp in a neuronal cell
            line and in the murine nervous system
  JOURNAL   J Biol Chem 269 (45), 28181-28186 (1994)
   PUBMED   7961754
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK044489.1, EU887585.1 and BP757417.1.
            
            Transcript Variant: This variant (8, also known as IA-deltaII-Xa)
            contains alternate 5' and 3' exon structure, and it thus differs in
            both UTRs, initiates translation at a downstream in-frame start
            codon, and differs in the 3' coding region, compared to variant 1.
            The encoded isoform (h) is shorter at at the N-terminus and has a
            distinct C-terminus, compared to isoform a. Both variants 8 and 13
            encode isoform h.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU887585.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..473
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 88.91 cM"
     Protein         1..473
                     /product="nuclear factor of activated T-cells, cytoplasmic
                     2 isoform h"
                     /note="nuclear factor of activated T-cells, cytoplasmic 2;
                     NFAT pre-existing subunit; T-cell transcription factor
                     NFAT1"
                     /calculated_mol_wt=52180
     Region          <1..124
                     /region_name="RHD-n"
                     /note="N-terminal sub-domain of the Rel homology domain
                     (RHD); cl08275"
                     /db_xref="CDD:447596"
     Region          129..229
                     /region_name="IPT_NFAT"
                     /note="IPT domain of the NFAT family of transcription
                     factors. NFAT transcription complexes are a target of
                     calcineurin, a calcium dependent phosphatase, and activate
                     genes mainly involved in cell-cell-interaction; cd01178"
                     /db_xref="CDD:238583"
     Site            order(153,217)
                     /site_type="DNA binding"
                     /note="DNA binding sites [nucleotide binding]"
                     /db_xref="CDD:238583"
     CDS             1..473
                     /gene="Nfatc2"
                     /gene_synonym="NF-ATc2; NF-ATp; NFAT1; NFAT1-D; Nfatp"
                     /coded_by="NM_001291171.1:374..1795"
                     /note="isoform h is encoded by transcript variant 8"
                     /db_xref="GeneID:18019"
                     /db_xref="MGI:MGI:102463"
ORIGIN      
        1 menkplglqi figtaderil kphafyqvhr itgktvttts yekivgntkv leiplepknn
       61 mratidcagi lklrnadiel rkgetdigrk ntrvrlvfrv hvpepsgriv slqaasnpie
      121 csqrsahelp mverqdmdsc lvyggqqmil tgqnftaesk vvfmekttdg qqiwemeatv
      181 dkdksqpnml fveipeyrnk hirvpvkvnf yvingkrkrs qpqhftyhpv paiktepsde
      241 yepslicspa hgglgsqpyy pqhpmlaesp sclvatmapc qqfrsglssp daryqqqspa
      301 aalyqrsksl spgllgyqqp sllaaplgla dahrsvlvha gsqgqgqgst lphtssasqq
      361 aspvihyspt nqqlrggghq efqhimycen fgpssarpgp ppinqgqrls pgayptviqq
      421 qtapsqraak ngpsdqkeal ptgvtvkqeq nldqtyldde lidthlswiq nil
//
LOCUS       NP_001390661             733 aa            linear   ROD 09-OCT-2023
DEFINITION  transcriptional repressor CTCF isoform 4 [Mus musculus].
ACCESSION   NP_001390661
VERSION     NP_001390661.1
DBSOURCE    REFSEQ: accession NM_001403732.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 733)
  AUTHORS   Hewitt SC, Gruzdev A, Willson CJ, Wu SP, Lydon JP, Galjart N and
            DeMayo FJ.
  TITLE     Chromatin architectural factor CTCF is essential for
            progesterone-dependent uterine maturation
  JOURNAL   FASEB J 37 (8), e23103 (2023)
   PUBMED   37489832
  REMARK    GeneRIF: Chromatin architectural factor CTCF is essential for
            progesterone-dependent uterine maturation.
REFERENCE   2  (residues 1 to 733)
  AUTHORS   Smits WK, Vermeulen C, Hagelaar R, Kimura S, Vroegindeweij EM,
            Buijs-Gladdines JGCAM, van de Geer E, Verstegen MJAM, Splinter E,
            van Reijmersdal SV, Buijs A, Galjart N, van Eyndhoven W, van Min M,
            Kuiper R, Kemmeren P, Mullighan CG, de Laat W and Meijerink JPP.
  TITLE     Elevated enhancer-oncogene contacts and higher oncogene expression
            levels by recurrent CTCF inactivating mutations in acute T cell
            leukemia
  JOURNAL   Cell Rep 42 (4), 112373 (2023)
   PUBMED   37060567
REFERENCE   3  (residues 1 to 733)
  AUTHORS   Wang B, Ji L and Bian Q.
  TITLE     SATB1 regulates 3D genome architecture in T cells by constraining
            chromatin interactions surrounding CTCF-binding sites
  JOURNAL   Cell Rep 42 (4), 112323 (2023)
   PUBMED   37000624
  REMARK    GeneRIF: SATB1 regulates 3D genome architecture in T cells by
            constraining chromatin interactions surrounding CTCF-binding sites.
REFERENCE   4  (residues 1 to 733)
  AUTHORS   Marina-Zarate E, Rodriguez-Ronchel A, Gomez MJ, Sanchez-Cabo F and
            Ramiro AR.
  TITLE     Low-affinity CTCF binding drives transcriptional regulation whereas
            high-affinity binding encompasses architectural functions
  JOURNAL   iScience 26 (3), 106106 (2023)
   PUBMED   36852270
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 733)
  AUTHORS   Hsieh TS, Cattoglio C, Slobodyanyuk E, Hansen AS, Darzacq X and
            Tjian R.
  TITLE     Enhancer-promoter interactions and transcription are largely
            maintained upon acute loss of CTCF, cohesin, WAPL or YY1
  JOURNAL   Nat Genet 54 (12), 1919-1932 (2022)
   PUBMED   36471071
  REMARK    GeneRIF: Enhancer-promoter interactions and transcription are
            largely maintained upon acute loss of CTCF, cohesin, WAPL or YY1.
REFERENCE   6  (residues 1 to 733)
  AUTHORS   Farrell CM, West AG and Felsenfeld G.
  TITLE     Conserved CTCF insulator elements flank the mouse and human
            beta-globin loci
  JOURNAL   Mol Cell Biol 22 (11), 3820-3831 (2002)
   PUBMED   11997516
  REMARK    GeneRIF: Conserved CTCF insulator elements flank the mouse and
            human beta-globin loci.
REFERENCE   7  (residues 1 to 733)
  AUTHORS   Burke LJ, Hollemann T, Pieler T and Renkawitz R.
  TITLE     Molecular cloning and expression of the chromatin insulator protein
            CTCF in Xenopus laevis
  JOURNAL   Mech Dev 113 (1), 95-98 (2002)
   PUBMED   11900981
REFERENCE   8  (residues 1 to 733)
  AUTHORS   Chao W, Huynh KD, Spencer RJ, Davidow LS and Lee JT.
  TITLE     CTCF, a candidate trans-acting factor for X-inactivation choice
  JOURNAL   Science 295 (5553), 345-347 (2002)
   PUBMED   11743158
  REMARK    GeneRIF: It's proposed that Tsix and CTCF together establish a
            regulatable epigenetic switch for X-inactivation.
REFERENCE   9  (residues 1 to 733)
  AUTHORS   Lutz M, Burke LJ, Barreto G, Goeman F, Greb H, Arnold R,
            Schultheiss H, Brehm A, Kouzarides T, Lobanenkov V and Renkawitz R.
  TITLE     Transcriptional repression by the insulator protein CTCF involves
            histone deacetylases
  JOURNAL   Nucleic Acids Res 28 (8), 1707-1713 (2000)
   PUBMED   10734189
REFERENCE   10 (residues 1 to 733)
  AUTHORS   Filippova GN, Fagerlie S, Klenova EM, Myers C, Dehner Y, Goodwin G,
            Neiman PE, Collins SJ and Lobanenkov VV.
  TITLE     An exceptionally conserved transcriptional repressor, CTCF, employs
            different combinations of zinc fingers to bind diverged promoter
            sequences of avian and mammalian c-myc oncogenes
  JOURNAL   Mol Cell Biol 16 (6), 2802-2813 (1996)
   PUBMED   8649389
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127419.3 and AC152826.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784646.823109.1,
                                           SRR13422598.816888.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..733
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.04 cM"
     Protein         1..733
                     /product="transcriptional repressor CTCF isoform 4"
                     /note="transcriptional repressor CTCF; CTCFL paralog;
                     11-zinc finger protein"
                     /calculated_mol_wt=83313
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          180..211
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61164.2)"
     Region          266..289
                     /region_name="zf-H2C2_5"
                     /note="C2H2-type zinc-finger domain; pfam13909"
                     /db_xref="CDD:404746"
     Region          268..288
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(273,275,277,279..280,283..284,287,301,303,307..308,
                     311..312,315,329,331,333,335..336,339..340,346)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          280..305
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:433230"
     Site            289
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          296..316
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          309..333
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:433230"
     Site            317
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          324..347
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          351..375
                     /region_name="zf-H2C2_5"
                     /note="C2H2-type zinc-finger domain; pfam13909"
                     /db_xref="CDD:404746"
     Region          353..373
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          <366..500
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Site            374
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          381..401
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            402
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          409..426
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          439..457
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          469..489
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(474,476,478,480..481,484..485,488,502,504,508..509,
                     512..513,516,530,532,534,536..537,540..541,545)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          497..517
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          509..534
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:433230"
     Region          525..546
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          557..573
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            609
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Site            610
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Site            612
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          696..723
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61164.2)"
     CDS             1..733
                     /gene="Ctcf"
                     /coded_by="NM_001403732.1:143..2344"
                     /note="isoform 4 is encoded by transcript variant 12"
                     /db_xref="GeneID:13018"
                     /db_xref="MGI:MGI:109447"
ORIGIN      
        1 megeaveaiv eesetfikgk erktyqrrre ggqeedachl pqnqtdggev vqdvnssvqm
       61 vmmeqldptl lqmktevmeg tvapeaeaav ddtqiitlqv vnmeeqpini gelqlvqvpv
      121 pvtvpvatts veelqgayen evskeglaes epmichtlpl pegfqvvkvg angevetleq
      181 gelppqedss wqkdpdyqpp akktkktkks klryteegkd vdvsvydfee eqqegllsev
      241 naekvvgnmk ppkptkikkk gvkktfqcel csytcprrsn ldrhmkshtd erphkchlcg
      301 rafrtvtllr nhlnthtgtr phkcpdcdma fvtsgelvrh rrykhthekp fkcsmcdyas
      361 vevsklkrhi rshtgerpfq cslcsyasrd tyklkrhmrt hsgekpyecy icharftqsg
      421 tmkmhilqkh tenvakfhcp hcdtviarks dlgvhlrkqh syieqgkkcr ycdavfhery
      481 aliqhqkshk nekrfkcdqc dyacrqerhm imhkrthtge kpyacshcdk tfrqkqlldm
      541 hfkryhdpnf vpaafvcskc gktftrrntm arhadncagp dgvegengge tkkskrgrkr
      601 kmrskkedss dsenaepdld dneeeeepav eiepepepqp qpppppqpva papppakkrr
      661 grppgrtnqp kqnqpiiqve dqntgaieni ivevkkepda epaegeeeea qaattdapng
      721 dltpemilsm mdr
//
LOCUS       NP_001103775             624 aa            linear   ROD 09-OCT-2023
DEFINITION  kelch-like ECH-associated protein 1 [Mus musculus].
ACCESSION   NP_001103775
VERSION     NP_001103775.1
DBSOURCE    REFSEQ: accession NM_001110305.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 624)
  AUTHORS   Li F, Huang H, Zhao P, Jiang J, Ding X, Lu D and Ji L.
  TITLE     Curculigoside mitigates dextran sulfate sodium-induced colitis by
            activation of KEAP1-NRF2 interaction to inhibit oxidative damage
            and autophagy of intestinal epithelium barrier
  JOURNAL   Int J Mol Med 52 (5) (2023)
   PUBMED   37772380
  REMARK    GeneRIF: Curculigoside mitigates dextran sulfate sodium-induced
            colitis by activation of KEAP1-NRF2 interaction to inhibit
            oxidative damage and autophagy of intestinal epithelium barrier.
REFERENCE   2  (residues 1 to 624)
  AUTHORS   Baird L, Taguchi K, Zhang A, Takahashi Y, Suzuki T, Kensler TW and
            Yamamoto M.
  TITLE     A NRF2-induced secretory phenotype activates immune surveillance to
            remove irreparably damaged cells
  JOURNAL   Redox Biol 66, 102845 (2023)
   PUBMED   37597423
REFERENCE   3  (residues 1 to 624)
  AUTHORS   Zhang A, Suzuki T, Adachi S, Yoshida E, Sakaguchi S and Yamamoto M.
  TITLE     Nrf2 activation improves experimental rheumatoid arthritis
  JOURNAL   Free Radic Biol Med 207, 279-295 (2023)
   PUBMED   37494986
  REMARK    GeneRIF: Nrf2 activation improves experimental rheumatoid
            arthritis.
REFERENCE   4  (residues 1 to 624)
  AUTHORS   Ushimoto C, Sugiki S, Kunii K, Inoue S, Kuroda E, Akai R, Iwawaki T
            and Miyazawa K.
  TITLE     Dynamic change and preventive role of stress response via
            Keap1-Nrf2 during renal crystal formation
  JOURNAL   Free Radic Biol Med 207, 120-132 (2023)
   PUBMED   37451369
  REMARK    GeneRIF: Dynamic change and preventive role of stress response via
            Keap1-Nrf2 during renal crystal formation.
REFERENCE   5  (residues 1 to 624)
  AUTHORS   Zhou M, Barkema HW, Gao J, Yang J, Wang Y, Kastelic JP, Khan S, Liu
            G and Han B.
  TITLE     MicroRNA miR-223 modulates NLRP3 and Keap1, mitigating
            lipopolysaccharide-induced inflammation and oxidative stress in
            bovine mammary epithelial cells and murine mammary glands
  JOURNAL   Vet Res 54 (1), 78 (2023)
   PUBMED   37710276
  REMARK    GeneRIF: MicroRNA miR-223 modulates NLRP3 and Keap1, mitigating
            lipopolysaccharide-induced inflammation and oxidative stress in
            bovine mammary epithelial cells and murine mammary glands.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 624)
  AUTHORS   Zipper LM and Mulcahy RT.
  TITLE     The Keap1 BTB/POZ dimerization function is required to sequester
            Nrf2 in cytoplasm
  JOURNAL   J Biol Chem 277 (39), 36544-36552 (2002)
   PUBMED   12145307
REFERENCE   7  (residues 1 to 624)
  AUTHORS   Dinkova-Kostova AT, Holtzclaw WD, Cole RN, Itoh K, Wakabayashi N,
            Katoh Y, Yamamoto M and Talalay P.
  TITLE     Direct evidence that sulfhydryl groups of Keap1 are the sensors
            regulating induction of phase 2 enzymes that protect against
            carcinogens and oxidants
  JOURNAL   Proc Natl Acad Sci U S A 99 (18), 11908-11913 (2002)
   PUBMED   12193649
  REMARK    GeneRIF: evidence that sulfhydryl groups of Keap1 are the sensors
            regulating induction of phase 2 enzymes that protect against
            carcinogens and oxidants
REFERENCE   8  (residues 1 to 624)
  AUTHORS   Kotilinek LA, Bacskai B, Westerman M, Kawarabayashi T, Younkin L,
            Hyman BT, Younkin S and Ashe KH.
  TITLE     Reversible memory loss in a mouse transgenic model of Alzheimer's
            disease
  JOURNAL   J Neurosci 22 (15), 6331-6335 (2002)
   PUBMED   12151510
REFERENCE   9  (residues 1 to 624)
  AUTHORS   Itoh K, Wakabayashi N, Katoh Y, Ishii T, Igarashi K, Engel JD and
            Yamamoto M.
  TITLE     Keap1 represses nuclear activation of antioxidant responsive
            elements by Nrf2 through binding to the amino-terminal Neh2 domain
  JOURNAL   Genes Dev 13 (1), 76-86 (1999)
   PUBMED   9887101
REFERENCE   10 (residues 1 to 624)
  AUTHORS   Chu CC and Paul WE.
  TITLE     Expressed genes in interleukin-4 treated B cells identified by cDNA
            representational difference analysis
  JOURNAL   Mol Immunol 35 (8), 487-502 (1998)
   PUBMED   9798653
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163637.4, AK150485.1, AK159858.1 and BY586021.1.
            
            Transcript Variant: This variant (2) uses a different splice site
            in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 all
            encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK039549.1, AK046178.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..624
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 7.74 cM"
     Protein         1..624
                     /product="kelch-like ECH-associated protein 1"
                     /note="NRF2 cytosolic inhibitor; cytosolic inhibitor of
                     Nrf2; ring canal protein"
                     /calculated_mol_wt=69422
     Region          56..180
                     /region_name="BTB_POZ_KLHL19_KEAP1"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in Kelch-like
                     ECH-associated protein 1 (KEAP1); cd18248"
                     /db_xref="CDD:349557"
     Region          95..596
                     /region_name="PHA03098"
                     /note="kelch-like protein; Provisional"
                     /db_xref="CDD:222983"
     Site            order(106,109..110,115..117,125..126,157,161..162)
                     /site_type="other"
                     /note="cullin binding site [polypeptide binding]"
                     /db_xref="CDD:349557"
     Site            order(129,131..132,147..148,150..151,154)
                     /site_type="other"
                     /note="modulator binding site [chemical binding]"
                     /db_xref="CDD:349557"
     Site            151
                     /site_type="other"
                     /note="Sensor for electrophilic agents.
                     /evidence=ECO:0000269|PubMed:18268004,
                     ECO:0000269|PubMed:22014577, ECO:0000269|PubMed:26527616;
                     propagated from UniProtKB/Swiss-Prot (Q9Z2X8.1)"
     Site            257
                     /site_type="other"
                     /note="Sensor for electrophilic agents.
                     /evidence=ECO:0000250|UniProtKB:Q14145; propagated from
                     UniProtKB/Swiss-Prot (Q9Z2X8.1)"
     Site            273
                     /site_type="other"
                     /note="Sensor for electrophilic agents.
                     /evidence=ECO:0000269|PubMed:14764894,
                     ECO:0000269|PubMed:26527616; propagated from
                     UniProtKB/Swiss-Prot (Q9Z2X8.1)"
     Site            288
                     /site_type="other"
                     /note="Sensor for electrophilic agents.
                     /evidence=ECO:0000269|PubMed:14764894,
                     ECO:0000269|PubMed:22014577, ECO:0000269|PubMed:26527616;
                     propagated from UniProtKB/Swiss-Prot (Q9Z2X8.1)"
     Region          327..372
                     /region_name="Kelch 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2X8.1)"
     Region          362..409
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          373..423
                     /region_name="Kelch 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2X8.1)"
     Region          413..456
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          424..470
                     /region_name="Kelch 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2X8.1)"
     Site            434
                     /site_type="other"
                     /note="Sensor for electrophilic agents.
                     /evidence=ECO:0000269|PubMed:20498371; propagated from
                     UniProtKB/Swiss-Prot (Q9Z2X8.1)"
     Region          460..503
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          471..517
                     /region_name="Kelch 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2X8.1)"
     Region          507..551
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          519..564
                     /region_name="Kelch 5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2X8.1)"
     Region          554..597
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          565..611
                     /region_name="Kelch 6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2X8.1)"
     CDS             1..624
                     /gene="Keap1"
                     /gene_synonym="INRF2; mKIAA0132"
                     /coded_by="NM_001110305.1:588..2462"
                     /db_xref="CCDS:CCDS22897.1"
                     /db_xref="GeneID:50868"
                     /db_xref="MGI:MGI:1858732"
ORIGIN      
        1 mqpepklsga prssqflplw skcpegagda vmyastecka evtpsqdgnr tfsytledht
       61 kqafgvmnel rlsqqlcdvt lqvkyedipa aqfmahkvvl assspvfkam ftnglreqgm
      121 evvsiegihp kvmerliefa ytasisvgek cvlhvmngav myqidsvvra csdflvqqld
      181 psnaigianf aeqigctelh qrareyiymh fgevakqeef fnlshcqlat lisrddlnvr
      241 cesevfhaci dwvkydcpqr rfyvqallra vrchaltprf lqtqlqkcei lqadarckdy
      301 lvqifqeltl hkptqavpcr apkvgrliyt aggyfrqsls yleaynpsng swlrladlqv
      361 prsglagcvv ggllyavggr nnspdgntds saldcynpmt nqwspcasms vprnrigvgv
      421 idghiyavgg shgcihhssv eryeperdew hlvapmltrr igvgvavlnr llyavggfdg
      481 tnrlnsaecy ypernewrmi tpmntirsga gvcvlhnciy aaggydgqdq lnsverydve
      541 tetwtfvapm rhhrsalgit vhqgkiyvlg gydghtflds vecydpdsdt wsevtrmtsg
      601 rsgvgvavtm epcrkqidqq nctc
//
LOCUS       NP_001152865             304 aa            linear   ROD 09-OCT-2023
DEFINITION  interferon regulatory factor 1 isoform b [Mus musculus].
ACCESSION   NP_001152865
VERSION     NP_001152865.1
DBSOURCE    REFSEQ: accession NM_001159393.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 304)
  AUTHORS   Kong P, Yang M, Wang Y, Yu KN, Wu L and Han W.
  TITLE     Ferroptosis triggered by STAT1- IRF1-ACSL4 pathway was involved in
            radiation-induced intestinal injury
  JOURNAL   Redox Biol 66, 102857 (2023)
   PUBMED   37611494
  REMARK    GeneRIF: Ferroptosis triggered by STAT1- IRF1-ACSL4 pathway was
            involved in radiation-induced intestinal injury.
REFERENCE   2  (residues 1 to 304)
  AUTHORS   Sharma BR, Karki R, Rajesh Y and Kanneganti TD.
  TITLE     Immune regulator IRF1 contributes to ZBP1-, AIM2-, RIPK1-, and
            NLRP12-PANoptosome activation and inflammatory cell death
            (PANoptosis)
  JOURNAL   J Biol Chem 299 (9), 105141 (2023)
   PUBMED   37557956
  REMARK    GeneRIF: Immune regulator IRF1 contributes to ZBP1-, AIM2-, RIPK1-,
            and NLRP12-PANoptosome activation and inflammatory cell death
            (PANoptosis).
REFERENCE   3  (residues 1 to 304)
  AUTHORS   Gungabeesoon J, Gort-Freitas NA, Kiss M, Bolli E, Messemaker M,
            Siwicki M, Hicham M, Bill R, Koch P, Cianciaruso C, Duval F,
            Pfirschke C, Mazzola M, Peters S, Homicsko K, Garris C, Weissleder
            R, Klein AM and Pittet MJ.
  TITLE     A neutrophil response linked to tumor control in immunotherapy
  JOURNAL   Cell 186 (7), 1448-1464 (2023)
   PUBMED   37001504
REFERENCE   4  (residues 1 to 304)
  AUTHORS   Chen X, Qi D, Fan S, He Y, Jing H and Wang D.
  TITLE     Interferon regulatory factor 1 (IRF1) inhibits lung endothelial
            regeneration following inflammation-induced acute lung injury
  JOURNAL   Clin Sci (Lond) 137 (5), 367-383 (2023)
   PUBMED   36857175
  REMARK    GeneRIF: Interferon regulatory factor 1 (IRF1) inhibits lung
            endothelial regeneration following inflammation-induced acute lung
            injury.
REFERENCE   5  (residues 1 to 304)
  AUTHORS   Rosain J, Neehus AL, Manry J, Yang R, Le Pen J, Daher W, Liu Z,
            Chan YH, Tahuil N, Turel O, Bourgey M, Ogishi M, Doisne JM,
            Izquierdo HM, Shirasaki T, Le Voyer T, Guerin A, Bastard P,
            Moncada-Velez M, Han JE, Khan T, Rapaport F, Hong SH, Cheung A,
            Haake K, Mindt BC, Perez L, Philippot Q, Lee D, Zhang P, Rinchai D,
            Al Ali F, Ahmad Ata MM, Rahman M, Peel JN, Heissel S, Molina H,
            Kendir-Demirkol Y, Bailey R, Zhao S, Bohlen J, Mancini M,
            Seeleuthner Y, Roelens M, Lorenzo L, Soudee C, Paz MEJ, Gonzalez
            ML, Jeljeli M, Soulier J, Romana S, L'Honneur AS, Materna M,
            Martinez-Barricarte R, Pochon M, Oleaga-Quintas C, Michev A, Migaud
            M, Levy R, Alyanakian MA, Rozenberg F, Croft CA, Vogt G, Emile JF,
            Kremer L, Ma CS, Fritz JH, Lemon SM, Spaan AN, Manel N, Abel L,
            MacDonald MR, Boisson-Dupuis S, Marr N, Tangye SG, Di Santo JP,
            Zhang Q, Zhang SY, Rice CM, Beziat V, Lachmann N, Langlais D,
            Casanova JL, Gros P and Bustamante J.
  TITLE     Human IRF1 governs macrophagic IFN-gamma immunity to mycobacteria
  JOURNAL   Cell 186 (3), 621-645 (2023)
   PUBMED   36736301
REFERENCE   6  (residues 1 to 304)
  AUTHORS   Gribaudo G, Caliendo A, Lembo D, Cavallo R and Landolfo S.
  TITLE     Molecular cloning of interferon-gamma inducible genes from a murine
            pre-B cell leukemia
  JOURNAL   J Biol Regul Homeost Agents 6 (4), 137-141 (1992)
   PUBMED   1296455
REFERENCE   7  (residues 1 to 304)
  AUTHORS   Tanaka N and Taniguchi T.
  TITLE     Cytokine gene regulation: regulatory cis-elements and DNA binding
            factors involved in the interferon system
  JOURNAL   Adv Immunol 52, 263-281 (1992)
   PUBMED   1442307
  REMARK    Review article
REFERENCE   8  (residues 1 to 304)
  AUTHORS   Buckwalter MS, Lossie AC, Scarlett LM and Camper SA.
  TITLE     Localization of the human chromosome 5q genes Gabra-1, Gabrg-2,
            Il-4, Il-5, and Irf-1 on mouse chromosome 11
  JOURNAL   Mamm Genome 3 (10), 604-607 (1992)
   PUBMED   1358285
REFERENCE   9  (residues 1 to 304)
  AUTHORS   Driggers PH, Ennist DL, Gleason SL, Mak WH, Marks MS, Levi BZ,
            Flanagan JR, Appella E and Ozato K.
  TITLE     An interferon gamma-regulated protein that binds the
            interferon-inducible enhancer element of major histocompatibility
            complex class I genes
  JOURNAL   Proc Natl Acad Sci U S A 87 (10), 3743-3747 (1990)
   PUBMED   2111015
REFERENCE   10 (residues 1 to 304)
  AUTHORS   Harada H, Fujita T, Miyamoto M, Kimura Y, Maruyama M, Furia A,
            Miyata T and Taniguchi T.
  TITLE     Structurally similar but functionally distinct factors, IRF-1 and
            IRF-2, bind to the same regulatory elements of IFN and
            IFN-inducible genes
  JOURNAL   Cell 58 (4), 729-739 (1989)
   PUBMED   2475256
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY266109.1 and AK152193.1.
            
            Transcript Variant: This variant (3) uses an alternate splice site
            in the 3' coding region, compared to variant 1. The resulting
            isoform (b) has a shorter and distinct C-terminus, compared to
            isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK152193.1, AK153514.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849374,
                                           SAMN00849375 [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..304
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 32.0 cM"
     Protein         1..304
                     /product="interferon regulatory factor 1 isoform b"
                     /calculated_mol_wt=34496
     Region          7..112
                     /region_name="IRF"
                     /note="Interferon regulatory factor transcription factor;
                     pfam00605"
                     /db_xref="CDD:425772"
     Site            order(40,80,82..83,86)
                     /site_type="other"
                     /note="DNA sequence recognition sites [nucleotide
                     binding]"
                     /db_xref="CDD:238051"
     Site            78
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P10914; propagated from
                     UniProtKB/Swiss-Prot (P15314.1)"
     Site            order(85..86,88,91)
                     /site_type="metal-binding"
                     /db_xref="CDD:238051"
     Region          93..166
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P15314.1)"
     CDS             1..304
                     /gene="Irf1"
                     /gene_synonym="Irf-1"
                     /coded_by="NM_001159393.1:270..1184"
                     /note="isoform b is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS48796.1"
                     /db_xref="GeneID:16362"
                     /db_xref="MGI:MGI:96590"
ORIGIN      
        1 mpitrmrmrp wlemqinsnq ipgliwinke emifqipwkh aakhgwdink daclfrswai
       61 htgrykagek epdpktwkan frcamnslpd ieevkdqsrn kgssavrvyr mlppltrnqr
      121 kerkskssrd tksktkrklc gdvspdtfsd glssstlpdd hssyttqgyl gqdldmerdi
      181 tpalspcvvs sslsewhmqm diipdsttdl ynlqvspmps tseaatdede egkiaedlmk
      241 lfeqsewqpt hidgkgylln epgtqlssvy gdfsckeepe idsprgnllm gvfcwlsawa
      301 saeh
//
LOCUS       NP_001397157             515 aa            linear   ROD 09-OCT-2023
DEFINITION  nuclear respiratory factor 1 isoform f [Mus musculus].
ACCESSION   NP_001397157 XP_036021814
VERSION     NP_001397157.1
DBSOURCE    REFSEQ: accession NM_001410228.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 515)
  AUTHORS   Cheng C, Tian Y, Yang R, Guo W, Xiao K, Zhang F, Tian J, Deng Z,
            Yang W, Yang H and Zhou Z.
  TITLE     miR-5581 Contributes to Osteoarthritis by Targeting NRF1 to Disturb
            the Proliferation and Functions of Chondrocytes
  JOURNAL   Am J Pathol 193 (9), 1234-1247 (2023)
   PUBMED   37611970
  REMARK    GeneRIF: miR-5581 Contributes to Osteoarthritis by Targeting NRF1
            to Disturb the Proliferation and Functions of Chondrocytes.
REFERENCE   2  (residues 1 to 515)
  AUTHORS   Meng Z, Liang B, Wu Y, Liu C, Wang H, Du Y, Gan L, Gao E, Lau WB,
            Christopher TA, Lopez BL, Koch WJ, Ma X, Zhao F, Wang Y and Zhao J.
  TITLE     Hypoadiponectinemia-induced upregulation of microRNA449b
            downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury
            in diabetic mice
  JOURNAL   J Mol Cell Cardiol 182, 1-14 (2023)
   PUBMED   37437402
  REMARK    GeneRIF: Hypoadiponectinemia-induced upregulation of microRNA449b
            downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury
            in diabetic mice.
REFERENCE   3  (residues 1 to 515)
  AUTHORS   Zhao T, Zhang J, Lei H, Meng Y, Cheng H, Zhao Y, Geng G, Mu C, Chen
            L, Liu Q, Luo Q, Zhang C, Long Y, Su J, Wang Y, Li Z, Sun J, Chen
            G, Li Y, Liao X, Shang Y, Hu G, Chen Q and Zhu Y.
  TITLE     NRF1-mediated mitochondrial biogenesis antagonizes innate antiviral
            immunity
  JOURNAL   EMBO J 42 (16), e113258 (2023)
   PUBMED   37409632
  REMARK    GeneRIF: NRF1-mediated mitochondrial biogenesis antagonizes innate
            antiviral immunity.
REFERENCE   4  (residues 1 to 515)
  AUTHORS   Akl MG, Baccetto R, Stebbings BM, Li L and Widenmaier SB.
  TITLE     Euglycemia is affected by stress defense factor hepatocyte NRF1,
            but not NRF2
  JOURNAL   Biochem Biophys Res Commun 668, 96-103 (2023)
   PUBMED   37245295
  REMARK    GeneRIF: Euglycemia is affected by stress defense factor hepatocyte
            NRF1, but not NRF2.
REFERENCE   5  (residues 1 to 515)
  AUTHORS   Akl MG, Li L, Baccetto R, Phanse S, Zhang Q, Trites MJ, McDonald S,
            Aoki H, Babu M and Widenmaier SB.
  TITLE     Complementary gene regulation by NRF1 and NRF2 protects against
            hepatic cholesterol overload
  JOURNAL   Cell Rep 42 (4), 112399 (2023)
   PUBMED   37060561
  REMARK    GeneRIF: Complementary gene regulation by NRF1 and NRF2 protects
            against hepatic cholesterol overload.
            Erratum:[Cell Rep. 2023 Jul 25;42(7):112872. PMID: 37454293]
REFERENCE   6  (residues 1 to 515)
  AUTHORS   Carmona MC, Iglesias R, Obregon MJ, Darlington GJ, Villarroya F and
            Giralt M.
  TITLE     Mitochondrial biogenesis and thyroid status maturation in brown fat
            require CCAAT/enhancer-binding protein alpha
  JOURNAL   J Biol Chem 277 (24), 21489-21498 (2002)
   PUBMED   11940593
REFERENCE   7  (residues 1 to 515)
  AUTHORS   Huo L and Scarpulla RC.
  TITLE     Mitochondrial DNA instability and peri-implantation lethality
            associated with targeted disruption of nuclear respiratory factor 1
            in mice
  JOURNAL   Mol Cell Biol 21 (2), 644-654 (2001)
   PUBMED   11134350
REFERENCE   8  (residues 1 to 515)
  AUTHORS   Schaefer L, Engman H and Miller JB.
  TITLE     Coding sequence, chromosomal localization, and expression pattern
            of Nrf1: the mouse homolog of Drosophila erect wing
  JOURNAL   Mamm Genome 11 (2), 104-110 (2000)
   PUBMED   10656923
REFERENCE   9  (residues 1 to 515)
  AUTHORS   Huo L and Scarpulla RC.
  TITLE     Multiple 5'-untranslated exons in the nuclear respiratory factor 1
            gene span 47 kb and contribute to transcript heterogeneity and
            translational efficiency
  JOURNAL   Gene 233 (1-2), 213-224 (1999)
   PUBMED   10375638
REFERENCE   10 (residues 1 to 515)
  AUTHORS   Virbasius CA, Virbasius JV and Scarpulla RC.
  TITLE     NRF-1, an activator involved in nuclear-mitochondrial interactions,
            utilizes a new DNA-binding domain conserved in a family of
            developmental regulators
  JOURNAL   Genes Dev 7 (12A), 2431-2445 (1993)
   PUBMED   8253388
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134897.4 and AC153632.2.
            
            On Aug 1, 2022 this sequence version replaced XP_036021814.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784643.1299742.1,
                                           SRR9219382.55428.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..515
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 12.47 cM"
     Protein         1..515
                     /product="nuclear respiratory factor 1 isoform f"
                     /note="NRF-1; alpha-pal; alpha palindromic-binding
                     protein"
                     /calculated_mol_wt=54726
     Region          87..295
                     /region_name="Nrf1_DNA-bind"
                     /note="NLS-binding and DNA-binding and dimerization
                     domains of Nrf1; pfam10491"
                     /db_xref="CDD:402218"
     Region          462..514
                     /region_name="Nrf1_activ_bdg"
                     /note="Nrf1 activator activation site binding domain;
                     pfam10492"
                     /db_xref="CDD:431313"
     CDS             1..515
                     /gene="Nrf1"
                     /gene_synonym="D6Ertd415e"
                     /coded_by="NM_001410228.1:271..1818"
                     /note="isoform f is encoded by transcript variant 18"
                     /db_xref="GeneID:18181"
                     /db_xref="MGI:MGI:1332235"
ORIGIN      
        1 meehgvtqte hmatieahav aqqvqqvhva tytehsmlsa dedspssped tsyddsdiln
       61 staadevtah laaavlgikp rashilgpvg maaaaavatg kkrkrphvfe snpsirkrqq
      121 trllrklrat ldeyttrvgq qaivlcisps kpnpvfkvfg aaplenvvrk yksmiledle
      181 salaehapap qevnselppl tidgipvsvd kmtqaqlraf ipemlkystg rgkpgwgkes
      241 ckpiwwpedi pwanvrsdvr teeqkqrvsw tqalrtivkn cykqhgredl lyafedqqtq
      301 tqattthsia hlvpsqtvvq tfsnpdgtvs liqvgtgatv atladaselp ttvtvaqvny
      361 savadgeveq nwatlqggem tiqttqasea tqavaslaea avaasqemqq gatvtmalns
      421 eaaahavatl aeatlqgggq ivlsgetaaa vgaltgvqda nglvqipvsm yqtvvtslaq
      481 gngpvqvama pvttrisdsa vtmdgqavev vtleq
//
LOCUS       NP_001277414             416 aa            linear   ROD 09-OCT-2023
DEFINITION  lysosome-associated membrane glycoprotein 2 isoform 3 precursor
            [Mus musculus].
ACCESSION   NP_001277414 XP_006541493
VERSION     NP_001277414.1
DBSOURCE    REFSEQ: accession NM_001290485.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 416)
  AUTHORS   Liu D, Xing R, Zhang Q, Tian X, Qi Y, Song H, Liu Y, Yu H, Zhang X,
            Jing Q, Yan C and Han Y.
  TITLE     The CREG1-FBXO27-LAMP2 axis alleviates diabetic cardiomyopathy by
            promoting autophagy in cardiomyocytes
  JOURNAL   Exp Mol Med 55 (9), 2025-2038 (2023)
   PUBMED   37658156
  REMARK    GeneRIF: The CREG1-FBXO27-LAMP2 axis alleviates diabetic
            cardiomyopathy by promoting autophagy in cardiomyocytes.
REFERENCE   2  (residues 1 to 416)
  AUTHORS   Wang Y, Hang K, Ying L, Wu J, Wu X, Zhang W, Li L, Wang Z, Bai J,
            Gao X, Xue D and Pan Z.
  TITLE     LAMP2A regulates the balance of mesenchymal stem cell
            adipo-osteogenesis via the Wnt/beta-catenin/GSK3beta signaling
            pathway
  JOURNAL   J Mol Med (Berl) 101 (7), 783-799 (2023)
   PUBMED   37162558
  REMARK    GeneRIF: LAMP2A regulates the balance of mesenchymal stem cell
            adipo-osteogenesis via the Wnt/beta-catenin/GSK3beta signaling
            pathway.
REFERENCE   3  (residues 1 to 416)
  AUTHORS   Zhang KK, Zhang P, Kodur A, Erturk I, Burns CM, Kenyon C, Miller RA
            and Endicott SJ.
  TITLE     LAMP2A, and other chaperone-mediated autophagy related proteins, do
            not decline with age in genetically heterogeneous UM-HET3 mice
  JOURNAL   Aging (Albany NY) 15 (11), 4685-4698 (2023)
   PUBMED   37315291
  REMARK    GeneRIF: LAMP2A, and other chaperone-mediated autophagy related
            proteins, do not decline with age in genetically heterogeneous
            UM-HET3 mice.
REFERENCE   4  (residues 1 to 416)
  AUTHORS   Maglica M, Kelam N, Haque E, Perutina I, Racetin A, Filipovic N,
            Katsuyama Y and Vukojevic K.
  TITLE     Immunoexpression Pattern of Autophagy Markers in Developing and
            Postnatal Kidneys of Dab1-/-(yotari) Mice
  JOURNAL   Biomolecules 13 (3), 402 (2023)
   PUBMED   36979337
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 416)
  AUTHORS   Sutton KA and Wilkinson MF.
  TITLE     The rapidly evolving Pem homeobox gene and Agtr2, Ant2, and Lamp2
            are closely linked in the proximal region of the mouse X chromosome
  JOURNAL   Genomics 45 (2), 447-450 (1997)
   PUBMED   9344676
REFERENCE   6  (residues 1 to 416)
  AUTHORS   Cella N, Cornejo-Uribe RR, Montes GS, Hynes NE and Chammas R.
  TITLE     The lysosomal-associated membrane protein LAMP-1 is a novel
            differentiation marker for HC11 mouse mammary epithelial cells
  JOURNAL   Differentiation 61 (2), 113-120 (1996)
   PUBMED   8983177
REFERENCE   7  (residues 1 to 416)
  AUTHORS   Gough NR, Hatem CL and Fambrough DM.
  TITLE     The family of LAMP-2 proteins arises by alternative splicing from a
            single gene: characterization of the avian LAMP-2 gene and
            identification of mammalian homologs of LAMP-2b and LAMP-2c
  JOURNAL   DNA Cell Biol 14 (10), 863-867 (1995)
   PUBMED   7546292
REFERENCE   8  (residues 1 to 416)
  AUTHORS   Dardik A, Smith RM and Schultz RM.
  TITLE     Colocalization of transforming growth factor-alpha and a functional
            epidermal growth factor receptor (EGFR) to the inner cell mass and
            preferential localization of the EGFR on the basolateral surface of
            the trophectoderm in the mouse blastocyst
  JOURNAL   Dev Biol 154 (2), 396-409 (1992)
   PUBMED   1426645
REFERENCE   9  (residues 1 to 416)
  AUTHORS   Granger BL, Green SA, Gabel CA, Howe CL, Mellman I and Helenius A.
  TITLE     Characterization and cloning of lgp110, a lysosomal membrane
            glycoprotein from mouse and rat cells
  JOURNAL   J Biol Chem 265 (20), 12036-12043 (1990)
   PUBMED   2142158
REFERENCE   10 (residues 1 to 416)
  AUTHORS   Cha Y, Holland SM and August JT.
  TITLE     The cDNA sequence of mouse LAMP-2. Evidence for two classes of
            lysosomal membrane glycoproteins
  JOURNAL   J Biol Chem 265 (9), 5008-5013 (1990)
   PUBMED   2318880
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK163933.1, AK078193.1, BQ176100.1 and AL513356.8.
            
            On Mar 13, 2014 this sequence version replaced XP_006541493.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK078193.1, SRR17784650.1034226.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..416
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 22.67 cM"
     Protein         1..416
                     /product="lysosome-associated membrane glycoprotein 2
                     isoform 3 precursor"
                     /note="lysosome-associated membrane glycoprotein 2; CD107
                     antigen-like family member B; lysosomal membrane
                     glycoprotein type B; lysosomal membrane glycoprotein 2"
                     /calculated_mol_wt=43181
     sig_peptide     1..25
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=2634
     Region          225..363
                     /region_name="Lamp"
                     /note="Lysosome-associated membrane glycoprotein (Lamp);
                     pfam01299"
                     /db_xref="CDD:426189"
     CDS             1..416
                     /gene="Lamp2"
                     /gene_synonym="CD107b; Lamp II; Lamp-2; Lamp-2a; Lamp-2b;
                     Lamp-2c; LGP-B; Mac3"
                     /coded_by="NM_001290485.2:158..1408"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 3"
                     /db_xref="CCDS:CCDS72369.1"
                     /db_xref="GeneID:16784"
                     /db_xref="MGI:MGI:96748"
ORIGIN      
        1 mclspvkgak liliflflga vqsnalivnl tdskgtclya ewemnftity ettnqtnkti
       61 tiavpdkath dgsscgddrn sakimiqfgf avswavnftk eashysihdi vlsyntsdst
      121 vfpgavakgv htvknpenfk vpldvifkcn svltynltpv vqkywgihlq afvqngtvsk
      181 neqvceedqt pttvapiiht tapsttttlt ptstptptpt ptptvgnysi rngnttclla
      241 tmglqlnite ekvpfifnin pattnftgsc qpqsaqlrln nsqikyldfi favknekrfy
      301 lkevnvymyl angsafnisn knlsfwdapl gssymcnkeq vlsvsrafqi ntfnlkvqpf
      361 nvtkgqysta eecaadsdln flipvavgva lgfliiavfi symigrrksr tgyqsv
//
LOCUS       NP_001349233             495 aa            linear   ROD 09-OCT-2023
DEFINITION  CUGBP Elav-like family member 4 isoform 28 [Mus musculus].
ACCESSION   NP_001349233 XP_017173282
VERSION     NP_001349233.1
DBSOURCE    REFSEQ: accession NM_001362304.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 495)
  AUTHORS   Salamon I, Park Y, Miskic T, Kopic J, Matteson P, Page NF, Roque A,
            McAuliffe GW, Favate J, Garcia-Forn M, Shah P, Judas M, Millonig
            JH, Kostovic I, De Rubeis S, Hart RP, Krsnik Z and Rasin MR.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    GeneRIF: Celf4 controls mRNA translation underlying synaptic
            development in the prenatal mammalian neocortex.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 495)
  AUTHORS   Shen Y, Zhang C, Xiao K, Liu D and Xie G.
  TITLE     CELF4 regulates spine formation and depression-like behaviors of
            mice
  JOURNAL   Biochem Biophys Res Commun 605, 39-44 (2022)
   PUBMED   35306363
  REMARK    GeneRIF: CELF4 regulates spine formation and depression-like
            behaviors of mice.
REFERENCE   3  (residues 1 to 495)
  AUTHORS   Moreau MX, Saillour Y, Cwetsch AW, Pierani A and Causeret F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   4  (residues 1 to 495)
  AUTHORS   Li C, Li X, Bi Z, Sugino K, Wang G, Zhu T and Liu Z.
  TITLE     Comprehensive transcriptome analysis of cochlear spiral ganglion
            neurons at multiple ages
  JOURNAL   Elife 9, e50491 (2020)
   PUBMED   31913118
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 495)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 495)
  AUTHORS   Ladd AN, Taffet G, Hartley C, Kearney DL and Cooper TA.
  TITLE     Cardiac tissue-specific repression of CELF activity disrupts
            alternative splicing and causes cardiomyopathy
  JOURNAL   Mol Cell Biol 25 (14), 6267-6278 (2005)
   PUBMED   15988035
  REMARK    GeneRIF: CELF protein activity is required for normal alternative
            splicing in the heart in vivo and normal CELF-mediated alternative
            splicing regulation is in turn required for normal cardiac
            function.
REFERENCE   7  (residues 1 to 495)
  AUTHORS   Meins M, Schlickum S, Wilhelm C, Missbach J, Yadav S, Glaser B,
            Grzmil M, Burfeind P and Laccone F.
  TITLE     Identification and characterization of murine Brunol4, a new member
            of the elav/bruno family
  JOURNAL   Cytogenet Genome Res 97 (3-4), 254-260 (2002)
   PUBMED   12438720
  REMARK    GeneRIF: cloning and characterization
REFERENCE   8  (residues 1 to 495)
  AUTHORS   Ladd AN, Charlet N and Cooper TA.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   9  (residues 1 to 495)
  AUTHORS   Good PJ, Chen Q, Warner SJ and Herring DC.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
REFERENCE   10 (residues 1 to 495)
  AUTHORS   Yulug IG, Egan SE, See CG and Fisher EM.
  TITLE     Mapping GRB2, a signal transduction gene in the human and the mouse
  JOURNAL   Genomics 22 (2), 313-318 (1994)
   PUBMED   7806216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121094.8 and AC144938.3.
            
            On Apr 12, 2018 this sequence version replaced XP_017173282.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660825.85301.1,
                                           SRR1660811.210590.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 13.92 cM"
     Protein         1..495
                     /product="CUGBP Elav-like family member 4 isoform 28"
                     /note="CUG-BP- and ETR-3-like factor 4; bruno-like protein
                     4; RNA-binding protein BRUNOL-4; bruno-like 4, RNA binding
                     protein"
                     /calculated_mol_wt=52901
     Region          49..135
                     /region_name="RRM1_CELF3_4_5_6"
                     /note="RNA recognition motif 1 (RRM1) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12632"
                     /db_xref="CDD:410041"
     Site            order(55,57,59..60,63,82,84,86,95..97,99,129,131)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410041"
     Region          141..221
                     /region_name="RRM2_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12635"
                     /db_xref="CDD:410043"
     Site            order(143,145,147..148,151,170,172,174,182..184,186,216,
                     218)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410043"
     Region          406..484
                     /region_name="RRM3_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12639"
                     /db_xref="CDD:241083"
     CDS             1..495
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /coded_by="NM_001362304.1:531..2018"
                     /note="isoform 28 is encoded by transcript variant 33"
                     /db_xref="GeneID:108013"
                     /db_xref="MGI:MGI:1932407"
ORIGIN      
        1 myikmatlan gqadnaslst nglgsspgsa ghmnglshsp gnpstipmkd hdaiklfigq
       61 iprnldekdl kplfeefgki yeltvlkdrf tgmhkgcafl tyceresalk aqsalheqkt
      121 lpgmnrpiqv kpadsesrge drklfvgmln kqqseddvrr lfeafgniee ctilrgpdgn
      181 skgcafvkys shaeaqaain alhgsqtmpg assslvvkfa dtdkertmrr mqqmagqmgm
      241 fnpmaipfga ygayaqalmq qqaalmasva qggylnpmaa faaaqmqqma alnmnglaaa
      301 pmtptsggst ppgitapavp sipspigvng ftglppqang qpaaeavfan gihpypaqsp
      361 taadplqqay agvqqyagpa ypaaygqisq afpqpppmip qqqregpegc nlliyhlpqe
      421 fgdaelmqmf lpfgnvissk vfvdratnqs kcfgfvsfdn pasaqtaiqa mngfqigmkr
      481 lkvqlkrpkd anrpy
//
LOCUS       NP_001342178              73 aa            linear   ROD 09-OCT-2023
DEFINITION  SWI/SNF-related matrix-associated actin-dependent regulator of
            chromatin subfamily A containing DEAD/H box 1 isoform 3 [Mus
            musculus].
ACCESSION   NP_001342178
VERSION     NP_001342178.1
DBSOURCE    REFSEQ: accession NM_001355249.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 73)
  AUTHORS   Sachs P, Bergmaier P, Treutwein K and Mermoud JE.
  TITLE     The Conserved Chromatin Remodeler SMARCAD1 Interacts with TFIIIC
            and Architectural Proteins in Human and Mouse
  JOURNAL   Genes (Basel) 14 (9), 1793 (2023)
   PUBMED   37761933
  REMARK    GeneRIF: The Conserved Chromatin Remodeler SMARCAD1 Interacts with
            TFIIIC and Architectural Proteins in Human and Mouse.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 73)
  AUTHORS   Bedogni F and Hevner RF.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 73)
  AUTHORS   Niu Q, Wang W, Wei Z, Byeon B, Das AB, Chen BS and Wu WH.
  TITLE     Role of the ATP-dependent chromatin remodeling enzyme
            Fun30/Smarcad1 in the regulation of mRNA splicing
  JOURNAL   Biochem Biophys Res Commun 526 (2), 453-458 (2020)
   PUBMED   32234239
  REMARK    GeneRIF: Role of the ATP-dependent chromatin remodeling enzyme
            Fun30/Smarcad1 in the regulation of mRNA splicing.
REFERENCE   4  (residues 1 to 73)
  AUTHORS   Kazakevych J, Denizot J, Liebert A, Portovedo M, Mosavie M, Jain P,
            Stellato C, Fraser C, Correa RO, Celestine M, Mattiuz R, Okkenhaug
            H, Miller JR, Vinolo MAR, Veldhoen M and Varga-Weisz P.
  TITLE     Smarcad1 mediates microbiota-induced inflammation in mouse and
            coordinates gene expression in the intestinal epithelium
  JOURNAL   Genome Biol 21 (1), 64 (2020)
   PUBMED   32160911
  REMARK    GeneRIF: Smarcad1 mediates microbiota-induced inflammation in mouse
            and coordinates gene expression in the intestinal epithelium.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 73)
  AUTHORS   Sachs P, Ding D, Bergmaier P, Lamp B, Schlagheck C, Finkernagel F,
            Nist A, Stiewe T and Mermoud JE.
  TITLE     SMARCAD1 ATPase activity is required to silence endogenous
            retroviruses in embryonic stem cells
  JOURNAL   Nat Commun 10 (1), 1335 (2019)
   PUBMED   30902974
  REMARK    GeneRIF: These findings uncover a role for the enzymatic activity
            of SMARCAD1 in cooperating with KAP1 to silence Endogenous
            retroviruses.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 73)
  AUTHORS   Ben-Arie N, McCall AE, Berkman S, Eichele G, Bellen HJ and Zoghbi
            HY.
  TITLE     Evolutionary conservation of sequence and expression of the bHLH
            protein Atonal suggests a conserved role in neurogenesis
  JOURNAL   Hum Mol Genet 5 (9), 1207-1216 (1996)
   PUBMED   8872459
REFERENCE   7  (residues 1 to 73)
  AUTHORS   Villeneuve L, Jiang X, Turmel C, Kozak CA and Jolicoeur P.
  TITLE     Long-range mapping of Mis-2, a common provirus integration site
            identified in murine leukemia virus-induced thymomas and located
            160 kilobase pairs downstream of Myb
  JOURNAL   J Virol 67 (10), 5733-5739 (1993)
   PUBMED   8371338
REFERENCE   8  (residues 1 to 73)
  AUTHORS   Schoor M, Schuster-Gossler K and Gossler A.
  TITLE     The Etl-1 gene encodes a nuclear protein differentially expressed
            during early mouse development
  JOURNAL   Dev Dyn 197 (3), 227-237 (1993)
   PUBMED   8219362
REFERENCE   9  (residues 1 to 73)
  AUTHORS   Soininen R, Schoor M, Henseling U, Tepe C, Kisters-Woike B, Rossant
            J and Gossler A.
  TITLE     The mouse Enhancer trap locus 1 (Etl-1): a novel mammalian gene
            related to Drosophila and yeast transcriptional regulator genes
  JOURNAL   Mech Dev 39 (1-2), 111-123 (1992)
   PUBMED   1489724
REFERENCE   10 (residues 1 to 73)
  AUTHORS   O'Kane CJ and Gehring WJ.
  TITLE     Detection in situ of genomic regulatory elements in Drosophila
  JOURNAL   Proc Natl Acad Sci U S A 84 (24), 9123-9127 (1987)
   PUBMED   2827169
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC138622.4.
            
            Transcript Variant: This variant (4) differs in the 5' UTR, lacks
            several exons and includes an alternate 3' terminal exon, compared
            to variant 1. The encoded protein (isoform 3) is shorter and has a
            distinct C-terminus, compared to isoform 1. Variants 3, 4, and 7
            all encode the same protein (isoform 3).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BG077183.2, SRR13422586.327073.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..73
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 30.11 cM"
     Protein         1..73
                     /product="SWI/SNF-related matrix-associated
                     actin-dependent regulator of chromatin subfamily A
                     containing DEAD/H box 1 isoform 3"
                     /EC_number="3.6.4.12"
                     /note="enhancer trap locus homolog 1; ATP-dependent
                     helicase SMARCAD1; enhancer trap locus 1"
                     /calculated_mol_wt=7806
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:Q9H4L7; propagated from
                     UniProtKB/Swiss-Prot (Q04692.2)"
     Site            54
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9H4L7; propagated from
                     UniProtKB/Swiss-Prot (Q04692.2)"
     Site            57
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H4L7; propagated from
                     UniProtKB/Swiss-Prot (Q04692.2)"
     CDS             1..73
                     /gene="Smarcad1"
                     /gene_synonym="D6Pas1; etl-1; Etl1; mKIAA1122"
                     /coded_by="NM_001355249.2:176..397"
                     /note="isoform 3 is encoded by transcript variant 4"
                     /db_xref="CCDS:CCDS90055.1"
                     /db_xref="GeneID:13990"
                     /db_xref="MGI:MGI:95453"
ORIGIN      
        1 mnlfnldrfr fekrskieea peaapqpsqa rpsspislsa eeenaegegs rantpdsdvt
       61 ektgsdfval alv
//
LOCUS       NP_033098               1388 aa            linear   ROD 09-OCT-2023
DEFINITION  rho-associated protein kinase 2 [Mus musculus].
ACCESSION   NP_033098
VERSION     NP_033098.2
DBSOURCE    REFSEQ: accession NM_009072.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1388)
  AUTHORS   Lee E, Chan SL, Lee Y, Polacheck WJ, Kwak S, Wen A, Nguyen DT,
            Kutys ML, Alimperti S, Kolarzyk AM, Kwak TJ, Eyckmans J, Bielenberg
            DR, Chen H and Chen CS.
  TITLE     A 3D biomimetic model of lymphatics reveals cell-cell junction
            tightening and lymphedema via a cytokine-induced ROCK2/JAM-A
            complex
  JOURNAL   Proc Natl Acad Sci U S A 120 (41), e2308941120 (2023)
   PUBMED   37782785
  REMARK    GeneRIF: A 3D biomimetic model of lymphatics reveals cell-cell
            junction tightening and lymphedema via a cytokine-induced
            ROCK2/JAM-A complex.
REFERENCE   2  (residues 1 to 1388)
  AUTHORS   Guo M, Zhang H, Zhang P, Yu J, Meng T, Li S, Song L, Chai Z, Yu J
            and Ma C.
  TITLE     [Knock-down of ROCK2 gene improves cognitive function and reduces
            neuronal apoptosis in AD mice by promoting mitochondrial fusion and
            inhibiting its division]
  JOURNAL   Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 39 (8), 701-707 (2023)
   PUBMED   37515336
  REMARK    GeneRIF: [Knock-down of ROCK2 gene improves cognitive function and
            reduces neuronal apoptosis in AD mice by promoting mitochondrial
            fusion and inhibiting its division].
REFERENCE   3  (residues 1 to 1388)
  AUTHORS   Jin X, Liao X, Wu L, Huang J, Li Z, Li Y and Guo F.
  TITLE     FOXO4 alleviates hippocampal neuronal damage in epileptic mice via
            the miR-138-5p/ROCK2 axis
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 189 (7-8), 271-284 (2022)
   PUBMED   35796190
  REMARK    GeneRIF: FOXO4 alleviates hippocampal neuronal damage in epileptic
            mice via the miR-138-5p/ROCK2 axis.
REFERENCE   4  (residues 1 to 1388)
  AUTHORS   Tseng CC, Zheng RH, Lin TW, Chou CC, Shih YC, Liang SW and Lee HH.
  TITLE     alpha-Actinin-4 recruits Shp2 into focal adhesions to potentiate
            ROCK2 activation in podocytes
  JOURNAL   Life Sci Alliance 5 (11), e202201557 (2022)
   PUBMED   36096674
  REMARK    GeneRIF: alpha-Actinin-4 recruits Shp2 into focal adhesions to
            potentiate ROCK2 activation in podocytes.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1388)
  AUTHORS   Chatterjee S, Patra D, Ghosh P, Banerjee S, Chowdhury KD,
            Chakraborty P, Basu A and Sadhukhan GC.
  TITLE     Activity of ROCKII not ROCKI promotes pulmonary metastasis of
            melanoma cells via modulating Smad2/3-MMP9 and FAK-Src-VEGF
            signalling
  JOURNAL   Cell Signal 97, 110389 (2022)
   PUBMED   35718242
  REMARK    GeneRIF: Activity of ROCKII not ROCKI promotes pulmonary metastasis
            of melanoma cells via modulating Smad2/3-MMP9 and FAK-Src-VEGF
            signalling.
REFERENCE   6  (residues 1 to 1388)
  AUTHORS   Zhao Z and Rivkees SA.
  TITLE     Rho-associated kinases play an essential role in cardiac
            morphogenesis and cardiomyocyte proliferation
  JOURNAL   Dev Dyn 226 (1), 24-32 (2003)
   PUBMED   12508221
REFERENCE   7  (residues 1 to 1388)
  AUTHORS   Gaikwad JS, Cavender A and D'Souza RN.
  TITLE     Identification of tooth-specific downstream targets of Runx2
  JOURNAL   Gene 279 (1), 91-97 (2001)
   PUBMED   11722849
REFERENCE   8  (residues 1 to 1388)
  AUTHORS   Wei L, Roberts W, Wang L, Yamada M, Zhang S, Zhao Z, Rivkees SA,
            Schwartz RJ and Imanaka-Yoshida K.
  TITLE     Rho kinases play an obligatory role in vertebrate embryonic
            organogenesis
  JOURNAL   Development 128 (15), 2953-2962 (2001)
   PUBMED   11532918
REFERENCE   9  (residues 1 to 1388)
  AUTHORS   Di Cunto F, Imarisio S, Hirsch E, Broccoli V, Bulfone A, Migheli A,
            Atzori C, Turco E, Triolo R, Dotto GP, Silengo L and Altruda F.
  TITLE     Defective neurogenesis in citron kinase knockout mice by altered
            cytokinesis and massive apoptosis
  JOURNAL   Neuron 28 (1), 115-127 (2000)
   PUBMED   11086988
REFERENCE   10 (residues 1 to 1388)
  AUTHORS   Nakagawa O, Fujisawa K, Ishizaki T, Saito Y, Nakao K and Narumiya
            S.
  TITLE     ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil
            forming protein serine/threonine kinase in mice
  JOURNAL   FEBS Lett 392 (2), 189-193 (1996)
   PUBMED   8772201
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ127012.1, AK163082.1, U58513.1, AK045517.1, CN536850.1,
            AK048955.1 and AK153280.1.
            
            On Mar 31, 2007 this sequence version replaced NP_033098.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849380,
                              SAMN00849381 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1388
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 8.04 cM"
     Protein         1..1388
                     /product="rho-associated protein kinase 2"
                     /EC_number="2.7.11.1"
                     /note="p164 ROCK-2; rho-associated, coiled-coil-containing
                     protein kinase 2; Rho-associated coiled-coil forming
                     kinage 2; rho-associated, coiled-coil-containing protein
                     kinase II"
                     /calculated_mol_wt=160485
     Region          1..26
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70336.1)"
     Region          39..417
                     /region_name="STKc_ROCK2"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     Rho-associated coiled-coil containing protein kinase 2;
                     cd05621"
                     /db_xref="CDD:270771"
     Site            order(53,65,67,71,74..75,78,84..88,91,157,404..406,
                     408..409,411,416)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:270771"
     Site            order(98..102,106,119,121,153,169..170,172,176,178,214,
                     216,218..219,221,231..232,235,250..255,286,292,295)
                     /site_type="active"
                     /db_xref="CDD:270771"
     Site            order(98..102,106,119,121,153,170..172,176,214,216,
                     218..219,221,231..232)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270771"
     Site            order(102,176,178,214,216,218,235,250..255,286,292,295)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270771"
     Site            231..255
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270771"
     Region          363..784
                     /region_name="Interaction with PPP1R12A.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P70336.1)"
     Region          373..420
                     /region_name="Interaction with NPM1.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P70336.1)"
     Site            410..415
                     /site_type="other"
                     /note="hydrophobic motif (HM)"
                     /db_xref="CDD:270771"
     Site            414
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by ROCK2.
                     /evidence=ECO:0000250|UniProtKB:Q62868; propagated from
                     UniProtKB/Swiss-Prot (P70336.1)"
     Region          <437..1101
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase [Cell cycle control,
                     cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:224117"
     Region          512..532
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70336.1)"
     Site            722
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by SRC.
                     /evidence=ECO:0000250|UniProtKB:O75116; propagated from
                     UniProtKB/Swiss-Prot (P70336.1)"
     Region          856..936
                     /region_name="ROCK_SBD"
                     /note="Shroom-binding domain found in Rho-associated
                     coiled-coil containing protein kinase; cd22250"
                     /db_xref="CDD:409019"
     Site            order(859,862..863,865..866,869..870,872..873,876..877,
                     879..880,883..884,886..887,890..891,900,904)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:409019"
     Site            order(861,864..865,867..869,871..872,874..879,882)
                     /site_type="other"
                     /note="Shroom binding site [polypeptide binding]"
                     /db_xref="CDD:409019"
     Region          979..1047
                     /region_name="RHOA binding. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P70336.1)"
     Site            1131..1132
                     /site_type="cleavage"
                     /note="Cleavage, by granzyme B; propagated from
                     UniProtKB/Swiss-Prot (P70336.1)"
     Site            1137
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P70336.1)"
     Region          1151..1257
                     /region_name="PH_ROCK"
                     /note="Rho-associated coiled-coil containing protein
                     kinase pleckstrin homology (PH) domain; cd01242"
                     /db_xref="CDD:269948"
     Site            1212
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:O75116; propagated from
                     UniProtKB/Swiss-Prot (P70336.1)"
     Region          1250..1320
                     /region_name="C1_ROCK2"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     found in Rho-associated coiled-coil containing protein
                     kinase 2 (ROCK2) and similar proteins; cd20875"
                     /db_xref="CDD:410425"
     Region          1345..1388
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70336.1)"
     Site            1362
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75116; propagated from
                     UniProtKB/Swiss-Prot (P70336.1)"
     Site            1374
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P70336.1)"
     CDS             1..1388
                     /gene="Rock2"
                     /gene_synonym="B230113H15Rik; mKIAA0619; Rho-kinase;
                     Rock-II; Rock2m; ROKalpha"
                     /coded_by="NM_009072.2:213..4379"
                     /db_xref="CCDS:CCDS36410.1"
                     /db_xref="GeneID:19878"
                     /db_xref="MGI:MGI:107926"
ORIGIN      
        1 msrppptgkm pgapetapgd gagagrqrkl ealirdprsp inveslldgl nslvldldfp
       61 alrknknidn flnryekivk kirglqmkae dydvvkvigr gafgevqlvr hkasqkvyam
      121 kllskfemik rsdsaffwee rdimafansp wvvqlfcafq ddrylymvme ympggdlvnl
      181 msnydvpekw akfytaevvl aldaihsmgl ihrdvkpdnm lldkhghlkl adfgtcmkmd
      241 etgmvhcdta vgtpdyispe vlksqggdgy ygrecdwwsv gvflfemlvg dtpfyadslv
      301 gtyskimdhk nslcfpedte iskhaknlic afltdrevrl grngveeikq hpffkndqwn
      361 wdniretaap vvpelssdid ssnfddiedd kgdvetfpip kafvgnqlpf igftyfrenl
      421 llsdsppcre ndaiqtrkse esqeiqkkly aleehlssev qakeeleqkc ksintrlekt
      481 akeleeeitl rksvestlrq lerekallqh knaeyqrkad headkkrnle ndvnslkdql
      541 edlkkrnqss qistekvnql qkqldeanal lrtesdtaar lrktqaessk qiqqlesnnr
      601 dlqdknclle taklklekef inlqsalese rrdrthgsei indlqgrisg leedlktgka
      661 llakvelekr qlqekltdle keksnmeidm tyqlkviqqs leqeeaehkt tkarladknk
      721 iyesieeaks eamkemekkl leerslkqkv enllleaekr csildcdlkq sqqklnellk
      781 qkdvlnedvr nltlkieqet qkrclmqndl kmqtqqvntl kmsekqikqe nnhlmemkmn
      841 lekqntelrk erqdadgqmk elqdqleaeq yfstlyktqv relkeeneek tklckelqqk
      901 kqdlqderds laaqleitlt kadseqlars iaeeqysdle kekimkelei kemmarhkqe
      961 ltekdttias leetnrtlts dvanlaneke elnnklkdsq eqlsklkdee msaaaikaqf
     1021 ekqllnertl ktqavnklae imnrkepvkr gsdtdvrrke kenrklhmel kserekltqq
     1081 mikyqkelne mqaqiaeesq irielqmtld skdsdieqlr sqlqalhigm dsssigsgpg
     1141 daepddgfpe srlegwlslp vrnntkkfgw vkkyvivssk kilfydseqd keqsnpymvl
     1201 didklfhvrp vtqtdvyrad akeiprifqi lyanegeskk epefpvepvg eksnyichkg
     1261 hefiptlyhf ptnceacmkp lwhmfkpppa lecrrchikc hkdhmdkkee iiapckvyyd
     1321 issaknllll ansteeqqkw vsrlvkkipk kppapdpfar ssprtsmkiq qnqsirrpsr
     1381 qlapnkps
//
LOCUS       NP_001295379             471 aa            linear   ROD 09-OCT-2023
DEFINITION  aldehyde dehydrogenase, mitochondrial isoform 2 precursor [Mus
            musculus].
ACCESSION   NP_001295379
VERSION     NP_001295379.1
DBSOURCE    REFSEQ: accession NM_001308450.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 471)
  AUTHORS   Qu Y, Liu Y and Zhang H.
  TITLE     ALDH2 activation attenuates oxygen-glucose
            deprivation/reoxygenation-induced cell apoptosis, pyroptosis,
            ferroptosis and autophagy
  JOURNAL   Clin Transl Oncol 25 (11), 3203-3216 (2023)
   PUBMED   37103763
  REMARK    GeneRIF: ALDH2 activation attenuates oxygen-glucose
            deprivation/reoxygenation-induced cell apoptosis, pyroptosis,
            ferroptosis and autophagy.
REFERENCE   2  (residues 1 to 471)
  AUTHORS   Chang YC, Lee HL, Yang W, Hsieh ML, Liu CC, Lee TY, Huang JY, Nong
            JY, Li FA, Chuang HL, Ding ZZ, Su WL, Chueh LY, Tsai YT, Chen CH,
            Mochly-Rosen D and Chuang LM.
  TITLE     A common East-Asian ALDH2 mutation causes metabolic disorders and
            the therapeutic effect of ALDH2 activators
  JOURNAL   Nat Commun 14 (1), 5971 (2023)
   PUBMED   37749090
  REMARK    GeneRIF: A common East-Asian ALDH2 mutation causes metabolic
            disorders and the therapeutic effect of ALDH2 activators.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 471)
  AUTHORS   Wang L, Tian M, Li R, Wu Y, Wang S, Lu H, Liu Z and Yu Y.
  TITLE     [Acetaldehyde dehydrogenase 2 ameliorates lung endothelial barrier
            and balances mitochondrial dynamics in mice with acute lung injury]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 43 (8), 1388-1395 (2023)
   PUBMED   37712276
  REMARK    GeneRIF: [Acetaldehyde dehydrogenase 2 ameliorates lung endothelial
            barrier and balances mitochondrial dynamics in mice with acute lung
            injury].
REFERENCE   4  (residues 1 to 471)
  AUTHORS   Wang M, Brandt LTL, Wang X, Russell H, Mitchell E, Kamimae-Lanning
            AN, Brown JM, Dingler FA, Garaycoechea JI, Isobe T, Kinston SJ, Gu
            M, Vassiliou GS, Wilson NK, Gottgens B and Patel KJ.
  TITLE     Genotoxic aldehyde stress prematurely ages hematopoietic stem cells
            in a p53-driven manner
  JOURNAL   Mol Cell 83 (14), 2417-2433 (2023)
   PUBMED   37348497
REFERENCE   5  (residues 1 to 471)
  AUTHORS   Lee AS, Sung YL, Pan SH, Sung KT, Su CH, Ding SL, Lu YJ, Hsieh CL,
            Chen YF, Liu CC, Chen WY, Chen XR, Chung FP, Wang SW, Chen CH,
            Mochly-Rosen D, Hung CL, Yeh HI and Lin SF.
  TITLE     A Common East Asian aldehyde dehydrogenase 2*2 variant promotes
            ventricular arrhythmia with chronic light-to-moderate alcohol use
            in mice
  JOURNAL   Commun Biol 6 (1), 610 (2023)
   PUBMED   37280327
  REMARK    GeneRIF: A Common East Asian aldehyde dehydrogenase 2*2 variant
            promotes ventricular arrhythmia with chronic light-to-moderate
            alcohol use in mice.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 471)
  AUTHORS   Fijneman RJ and Demant P.
  TITLE     A gene for susceptibility to small intestinal cancer, ssic1, maps
            to the distal part of mouse chromosome 4
  JOURNAL   Cancer Res 55 (14), 3179-3182 (1995)
   PUBMED   7606739
REFERENCE   7  (residues 1 to 471)
  AUTHORS   Chang C and Yoshida A.
  TITLE     Cloning and characterization of the gene encoding mouse
            mitochondrial aldehyde dehydrogenase
  JOURNAL   Gene 148 (2), 331-336 (1994)
   PUBMED   7958964
REFERENCE   8  (residues 1 to 471)
  AUTHORS   Caubin J, Iglesias T, Bernal J, Munoz A, Marquez G, Barbero JL and
            Zaballos A.
  TITLE     Isolation of genomic DNA fragments corresponding to genes modulated
            in vivo by a transcription factor
  JOURNAL   Nucleic Acids Res 22 (20), 4132-4138 (1994)
   PUBMED   7937138
REFERENCE   9  (residues 1 to 471)
  AUTHORS   Chen M, Achkar C and Gudas LJ.
  TITLE     Enzymatic conversion of retinaldehyde to retinoic acid by cloned
            murine cytosolic and mitochondrial aldehyde dehydrogenases
  JOURNAL   Mol Pharmacol 46 (1), 88-96 (1994)
   PUBMED   8058062
REFERENCE   10 (residues 1 to 471)
  AUTHORS   McCaffery P, Tempst P, Lara G and Drager UC.
  TITLE     Aldehyde dehydrogenase is a positional marker in the retina
  JOURNAL   Development 112 (3), 693-702 (1991)
   PUBMED   1935685
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK165032.1, AK043506.1 and CO039039.1.
            
            Transcript Variant: This variant (2) lacks two alternate 3' exons
            and has a 3' end that extends into an intron compared to variant 1.
            The resulting isoform (2) has a shorter C-terminus compared to
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK043506.1, SRR7345562.279537.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 61.86 cM"
     Protein         1..471
                     /product="aldehyde dehydrogenase, mitochondrial isoform 2
                     precursor"
                     /EC_number="1.2.1.3"
                     /note="aldehyde dehydrogenase, mitochondrial; ALDH class
                     2"
                     /calculated_mol_wt=49187
     transit_peptide 1..19
                     /note="Mitochondrion. /evidence=ECO:0000250; propagated
                     from UniProtKB/Swiss-Prot (P47738.1)"
                     /calculated_mol_wt=2181
     Region          33..471
                     /region_name="ALDH_F1AB_F2_RALDH1"
                     /note="NAD+-dependent retinal dehydrogenase 1, ALDH
                     families 1A, 1B, and 2-like; cd07141"
                     /db_xref="CDD:143459"
     Site            54
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P47738.1)"
     Site            75
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P47738.1)"
     Site            80
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P47738.1)"
     Site            161
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P47738.1)"
     Site            order(184..187,211,214,244,248..249,262,265,268,288..289,
                     321,368,371,418)
                     /site_type="other"
                     /note="NAD binding site [chemical binding]"
                     /db_xref="CDD:143459"
     Site            order(188,287,318,321)
                     /site_type="active"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:143459"
     Site            188
                     /site_type="other"
                     /note="Transition state stabilizer.
                     /evidence=ECO:0000250|UniProtKB:P20000; propagated from
                     UniProtKB/Swiss-Prot (P47738.1)"
     Site            370
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P47738.1)"
     Site            377
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P47738.1)"
     Site            385
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P47738.1)"
     Site            409
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P47738.1)"
     Site            428
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P47738.1)"
     Site            430
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753,
                     ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P47738.1)"
     Site            443
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P47738.1)"
     Site            453
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P47738.1)"
     CDS             1..471
                     /gene="Aldh2"
                     /gene_synonym="Ahd-5; AHD-M1; Ahd5; ALDH-E2; ALDHI"
                     /coded_by="NM_001308450.1:344..1759"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2"
                     /db_xref="CCDS:CCDS84951.1"
                     /db_xref="GeneID:11669"
                     /db_xref="MGI:MGI:99600"
ORIGIN      
        1 mlraalttvr rgprlsrlls aaatsavpap nhqpevfcnq ifinnewhda vsrktfptvn
       61 pstgevicqv aegnkedvdk avkaaraafq lgspwrrmda sdrgrllyrl adlierdrty
      121 laaletldng kpyvisylvd ldmvlkclry yagwadkyhg ktipidgdff sytrhepvgv
      181 cgqiipwnfp llmqawklgp alatgnvvvm kvaeqtplta lyvanlikea gfppgvvniv
      241 pgfgptagaa iashegvdkv aftgstevgh liqvaagssn lkrvtlelgg kspniimsda
      301 dmdwaveqah falffnqgqc ccagsrtfvq envydefver svaraksrvv gnpfdsrteq
      361 gpqvdetqfk kilgyiksgq qegakllcgg gaaadrgyfi qptvfgdvkd gmtiakeeif
      421 gpvmqilkfk tieevvgran dskyglaaav ftkdldkany lsqalqagtv w
//
LOCUS       NP_001013385             559 aa            linear   ROD 09-OCT-2023
DEFINITION  5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 1
            [Mus musculus].
ACCESSION   NP_001013385 XP_139298
VERSION     NP_001013385.3
DBSOURCE    REFSEQ: accession NM_001013367.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 559)
  AUTHORS   Yang Y, Yuan K, Liu Y, Wang Q, Lin Y, Yang S, Huang K, Kan T, Zhang
            Y, Xu M, Yu Z, Fan Q, Wang Y, Li H and Tang T.
  TITLE     Constitutively activated AMPKalpha1 protects against skeletal aging
            in mice by promoting bone-derived IGF-1 secretion
  JOURNAL   Cell Prolif 56 (10), e13476 (2023)
   PUBMED   37042047
  REMARK    GeneRIF: Constitutively activated AMPKalpha1 protects against
            skeletal aging in mice by promoting bone-derived IGF-1 secretion.
REFERENCE   2  (residues 1 to 559)
  AUTHORS   Zahedi E, Sadr SS, Sanaeierad A and Roghani M.
  TITLE     Valproate-induced murine autism spectrum disorder is associated
            with dysfunction of amygdala parvalbumin interneurons and
            downregulation of AMPK/SIRT1/PGC1alpha signaling
  JOURNAL   Metab Brain Dis 38 (6), 2093-2103 (2023)
   PUBMED   37184727
  REMARK    GeneRIF: Valproate-induced murine autism spectrum disorder is
            associated with dysfunction of amygdala parvalbumin interneurons
            and downregulation of AMPK/SIRT1/PGC1alpha signaling.
REFERENCE   3  (residues 1 to 559)
  AUTHORS   Knaus LS, Basilico B, Malzl D, Gerykova Bujalkova M, Smogavec M,
            Schwarz LA, Gorkiewicz S, Amberg N, Pauler FM, Knittl-Frank C,
            Tassinari M, Maulide N, Rulicke T, Menche J, Hippenmeyer S and
            Novarino G.
  TITLE     Large neutral amino acid levels tune perinatal neuronal
            excitability and survival
  JOURNAL   Cell 186 (9), 1950-1967 (2023)
   PUBMED   36996814
REFERENCE   4  (residues 1 to 559)
  AUTHORS   Bustamante-Barrientos FA, Mendez-Ruette M, Molina L, Koning T,
            Ehrenfeld P, Gonzalez CB, Wyneken U, Henzi R and Batiz LF.
  TITLE     Alpha-SNAP (M105I) mutation promotes neuronal differentiation of
            neural stem/progenitor cells through overactivation of AMPK
  JOURNAL   Front Cell Dev Biol 11, 1061777 (2023)
   PUBMED   37113766
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 559)
  AUTHORS   Aguiar CF, Correa-da-Silva F, Gonzatti MB, Angelim MK, Pretti MA,
            Davanzo GG, Castelucci BG, Monteiro LB, Castro G, Virgilio-da-Silva
            JV, Ribeiro G, Jaccomo V, Pereira Andrade MC, Costa WL, Gambarini
            V, Terra FF, Alves-Filho JC, Saraiva Camara NO, Boroni M, Keller AC
            and Moraes-Vieira PM.
  TITLE     Tissue-specific metabolic profile drives iNKT cell function during
            obesity and liver injury
  JOURNAL   Cell Rep 42 (1), 112035 (2023)
   PUBMED   36848232
REFERENCE   6  (residues 1 to 559)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (residues 1 to 559)
  AUTHORS   Sato T, Sato-Harada R, Takano M, Kato S, Saburi S and Harada A.
  TITLE     Localization of cAMP-dependent protein kinase in the actin and
            microtubule cytoskeletons in mouse hippocampal neurons
  JOURNAL   Neurosci Lett 325 (2), 83-86 (2002)
   PUBMED   12044627
REFERENCE   8  (residues 1 to 559)
  AUTHORS   Fryer LG, Foufelle F, Barnes K, Baldwin SA, Woods A and Carling D.
  TITLE     Characterization of the role of the AMP-activated protein kinase in
            the stimulation of glucose transport in skeletal muscle cells
  JOURNAL   Biochem J 363 (Pt 1), 167-174 (2002)
   PUBMED   11903059
REFERENCE   9  (residues 1 to 559)
  AUTHORS   Piao Y, Ko NT, Lim MK and Ko MS.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (residues 1 to 559)
  AUTHORS   Turnley AM, Stapleton D, Mann RJ, Witters LA, Kemp BE and Bartlett
            PF.
  TITLE     Cellular distribution and developmental expression of AMP-activated
            protein kinase isoforms in mouse central nervous system
  JOURNAL   J Neurochem 72 (4), 1707-1716 (1999)
   PUBMED   10098881
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY134921.1, AK160612.1, CB245934.1, AK081874.1 and AC135079.9.
            
            On May 5, 2006 this sequence version replaced NP_001013385.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086695.1, SRR1660813.253715.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..559
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 1.99 cM"
     Protein         1..559
                     /product="5'-AMP-activated protein kinase catalytic
                     subunit alpha-1 isoform 1"
                     /EC_number="2.7.11.1"
                     /EC_number="2.7.11.26"
                     /EC_number="2.7.11.27"
                     /EC_number="2.7.11.31"
                     /note="5'-AMP-activated protein kinase catalytic subunit
                     alpha-1; AMP-activated protein kinase, alpha 1 catalytic
                     subunit; AMPK subunit alpha-1; ACACA kinase; HMGCR kinase;
                     acetyl-CoA carboxylase kinase; hydroxymethylglutaryl-CoA
                     reductase kinase; tau-protein kinase PRKAA1"
                     /calculated_mol_wt=63798
     Region          24..279
                     /region_name="STKc_AMPK_alpha"
                     /note="Catalytic domain of the Alpha subunit of the
                     Serine/Threonine Kinase, AMP-activated protein kinase;
                     cd14079"
                     /db_xref="CDD:270981"
     Site            32
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q13131; propagated from
                     UniProtKB/Swiss-Prot (Q5EG47.2)"
     Site            order(33..37,41,54,56,88,104..107,111,113..114,116,
                     149..150,152,154..155,157,167..168,171,185..189,191,
                     221..224)
                     /site_type="active"
                     /db_xref="CDD:270981"
     Site            order(33..36,41,54,56,88,104..107,111,154..155,157,
                     167..168)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270981"
     Site            order(111,113..114,116,150,152,154,171,185..189,191,
                     221..224)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270981"
     Site            167..189
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270981"
     Site            order(175..180,199..200,202,205,265)
                     /site_type="other"
                     /note="heterotrimer interface [polypeptide binding]"
                     /db_xref="CDD:270981"
     Site            183
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by LKB1 and CaMKK2.
                     /evidence=ECO:0000269|PubMed:15980064,
                     ECO:0000269|PubMed:16054095, ECO:0000269|PubMed:16308421;
                     propagated from UniProtKB/Swiss-Prot (Q5EG47.2)"
     Region          296..360
                     /region_name="UBA_AID_AAPK1"
                     /note="UBA-like autoinhibitory domain (AID) found in
                     vertebrate 5'-AMP-activated protein kinase catalytic
                     subunit alpha-1 (AMPKalpha-1); cd14403"
                     /db_xref="CDD:270586"
     Region          302..381
                     /region_name="AIS. /evidence=ECO:0000250|UniProtKB:Q13131"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5EG47.2)"
     Site            355
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q13131; propagated from
                     UniProtKB/Swiss-Prot (Q5EG47.2)"
     Site            356
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13131; propagated from
                     UniProtKB/Swiss-Prot (Q5EG47.2)"
     Site            360
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by ULK1.
                     /evidence=ECO:0000250|UniProtKB:P54645; propagated from
                     UniProtKB/Swiss-Prot (Q5EG47.2)"
     Site            368
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by ULK1.
                     /evidence=ECO:0000250|UniProtKB:P54645; propagated from
                     UniProtKB/Swiss-Prot (Q5EG47.2)"
     Site            382
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q13131; propagated from
                     UniProtKB/Swiss-Prot (Q5EG47.2)"
     Site            397
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by ULK1.
                     /evidence=ECO:0000250|UniProtKB:P54645; propagated from
                     UniProtKB/Swiss-Prot (Q5EG47.2)"
     Region          404..557
                     /region_name="AMPKA1_C"
                     /note="C-terminal regulatory domain of 5'-AMP-activated
                     protein kinase (AMPK) alpha 1 catalytic subunit; cd12199"
                     /db_xref="CDD:213384"
     Site            order(404..410,412,417,439..441,461..465,470,473..476,478,
                     543,546..548,550..551,555)
                     /site_type="other"
                     /note="beta subunit interface [polypeptide binding]"
                     /db_xref="CDD:213384"
     Site            order(404,449,451,541..542,544..545,548)
                     /site_type="other"
                     /note="gamma subunit interface [polypeptide binding]"
                     /db_xref="CDD:213384"
     Site            467
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13131; propagated from
                     UniProtKB/Swiss-Prot (Q5EG47.2)"
     Region          485..536
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5EG47.2)"
     Site            486
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q5EG47.2)"
     Site            488
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by ULK1.
                     /evidence=ECO:0000250|UniProtKB:P54645; propagated from
                     UniProtKB/Swiss-Prot (Q5EG47.2)"
     Site            490
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q5EG47.2)"
     Site            496
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19144319; propagated from
                     UniProtKB/Swiss-Prot (Q5EG47.2)"
     Site            508
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13131; propagated from
                     UniProtKB/Swiss-Prot (Q5EG47.2)"
     Site            524
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13131; propagated from
                     UniProtKB/Swiss-Prot (Q5EG47.2)"
     Site            527
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13131; propagated from
                     UniProtKB/Swiss-Prot (Q5EG47.2)"
     CDS             1..559
                     /gene="Prkaa1"
                     /gene_synonym="AMPKalpha1; C130083N04Rik"
                     /coded_by="NM_001013367.3:9..1688"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS49574.1"
                     /db_xref="GeneID:105787"
                     /db_xref="MGI:MGI:2145955"
ORIGIN      
        1 mrrlsswrkm ataekqkhdg rvkighyilg dtlgvgtfgk vkvgkheltg hkvavkilnr
       61 qkirsldvvg kirreiqnlk lfrhphiikl yqvistpsdi fmvmeyvsgg elfdyickng
      121 rldekesrrl fqqilsgvdy chrhmvvhrd lkpenvllda hmnakiadfg lsnmmsdgef
      181 lrtscgspny aapevisgrl yagpevdiws sgvilyallc gtlpfdddhv ptlfkkicdg
      241 ifytpqylnp svisllkhml qvdpmkraai kdirehewfk qdlpkylfpe dpsysstmid
      301 dealkevcek fecseeevls clynrnhqdp lavayhliid nrrimneakd fylatsppds
      361 flddhhltrp hpervpflva etprarhtld elnpqkskhq gvrkakwhlg irsqsrpndi
      421 maevcraikq ldyewkvvnp yylrvrrknp vtstfskmsl qlyqvdsrty lldfrsidde
      481 iteaksgtat pqrsgsisny rscqrsdsda eaqgkpsdvs ltssvtslds spvdvaprpg
      541 shtieffemc anlikilaq
//
LOCUS       NP_001157104             764 aa            linear   ROD 09-OCT-2023
DEFINITION  DNA-binding protein SATB1 isoform 1 [Mus musculus].
ACCESSION   NP_001157104
VERSION     NP_001157104.1
DBSOURCE    REFSEQ: accession NM_001163632.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 764)
  AUTHORS   Naito T, Ise M, Tanaka Y, Kohwi-Shigematsu T and Kondo M.
  TITLE     Crucial Roles of SATB1 in Regulation of Thymocyte Migration after
            Positive Selection
  JOURNAL   J Immunol 211 (2), 209-218 (2023)
   PUBMED   37256264
  REMARK    GeneRIF: Crucial Roles of SATB1 in Regulation of Thymocyte
            Migration after Positive Selection.
REFERENCE   2  (residues 1 to 764)
  AUTHORS   Nomura A, Kobayashi T, Seo W, Ohno-Oishi M, Kakugawa K, Muroi S,
            Yoshida H, Endo TA, Moro K and Taniuchi I.
  TITLE     Identification of a novel enhancer essential for Satb1 expression
            in TH2 cells and activated ILC2s
  JOURNAL   Life Sci Alliance 6 (8), e202301897 (2023)
   PUBMED   37193606
  REMARK    GeneRIF: Identification of a novel enhancer essential for Satb1
            expression in TH2 cells and activated ILC2s.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 764)
  AUTHORS   Knowles SJ, Stafford AM, Zaman T, Angara K, Williams MR, Newbern JM
            and Vogt D.
  TITLE     Distinct hyperactive RAS/MAPK alleles converge on common GABAergic
            interneuron core programs
  JOURNAL   Development 150 (10) (2023)
   PUBMED   37254876
REFERENCE   4  (residues 1 to 764)
  AUTHORS   Wang B, Ji L and Bian Q.
  TITLE     SATB1 regulates 3D genome architecture in T cells by constraining
            chromatin interactions surrounding CTCF-binding sites
  JOURNAL   Cell Rep 42 (4), 112323 (2023)
   PUBMED   37000624
  REMARK    GeneRIF: SATB1 regulates 3D genome architecture in T cells by
            constraining chromatin interactions surrounding CTCF-binding sites.
REFERENCE   5  (residues 1 to 764)
  AUTHORS   Vasilopoulos N, Kaplanian A, Vinos M, Katsaiti Y, Christodoulou O,
            Denaxa M and Skaliora I.
  TITLE     The role of selective SATB1 deletion in somatostatin expressing
            interneurons on endogenous network activity and the transition to
            epilepsy
  JOURNAL   J Neurosci Res 101 (4), 424-447 (2023)
   PUBMED   36541427
  REMARK    GeneRIF: The role of selective SATB1 deletion in somatostatin
            expressing interneurons on endogenous network activity and the
            transition to epilepsy.
REFERENCE   6  (residues 1 to 764)
  AUTHORS   Seo J, Lozano MM and Dudley JP.
  TITLE     Nuclear matrix binding regulates SATB1-mediated transcriptional
            repression
  JOURNAL   J Biol Chem 280 (26), 24600-24609 (2005)
   PUBMED   15851481
  REMARK    GeneRIF: SATB1-mediated transcriptional repression is regulated by
            nuclear matrix binding
REFERENCE   7  (residues 1 to 764)
  AUTHORS   Nie H, Maika SD, Tucker PW and Gottlieb PD.
  TITLE     A role for SATB1, a nuclear matrix association region-binding
            protein, in the development of CD8SP thymocytes and peripheral T
            lymphocytes
  JOURNAL   J Immunol 174 (8), 4745-4752 (2005)
   PUBMED   15814699
  REMARK    GeneRIF: essential role for SATB1 late in the development and
            maturation of CD8SP T cells
REFERENCE   8  (residues 1 to 764)
  AUTHORS   Cai S, Han HJ and Kohwi-Shigematsu T.
  TITLE     Tissue-specific nuclear architecture and gene expression regulated
            by SATB1
  JOURNAL   Nat Genet 34 (1), 42-51 (2003)
   PUBMED   12692553
  REMARK    GeneRIF: in thymocyte nuclei, SATB1 has a cage-like 'network'
            distribution circumscribing heterochromatin and selectively tethers
            specialized DNA sequences onto its network
REFERENCE   9  (residues 1 to 764)
  AUTHORS   Alvarez JD, Yasui DH, Niida H, Joh T, Loh DY and Kohwi-Shigematsu
            T.
  TITLE     The MAR-binding protein SATB1 orchestrates temporal and spatial
            expression of multiple genes during T-cell development
  JOURNAL   Genes Dev 14 (5), 521-535 (2000)
   PUBMED   10716941
REFERENCE   10 (residues 1 to 764)
  AUTHORS   Nakagomi K, Kohwi Y, Dickinson LA and Kohwi-Shigematsu T.
  TITLE     A novel DNA-binding motif in the nuclear matrix attachment
            DNA-binding protein SATB1
  JOURNAL   Mol Cell Biol 14 (3), 1852-1860 (1994)
   PUBMED   8114718
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154796.2, AK134040.1, AK037740.1, AK081385.1, AC131975.28 and
            AW045567.1.
            
            Transcript Variant: This variant (4) differs in the 5' UTR compared
            to variant 1. Variants 1-4 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011132.1, SRR7974084.10598.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..764
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 26.81 cM"
     Protein         1..764
                     /product="DNA-binding protein SATB1 isoform 1"
                     /note="DNA-binding protein Satb1"
                     /calculated_mol_wt=85749
     Region          1..56
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60611.2)"
     Region          20..40
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60611.2)"
     Region          72..170
                     /region_name="ULD"
                     /note="Ubiquitin-like oligomerization domain of SATB;
                     pfam16534"
                     /db_xref="CDD:435405"
     Site            order(75,77,94..98,100,132,134,137..138,144..147,155..156,
                     159..161,163..164)
                     /site_type="other"
                     /note="tetramer interface [polypeptide binding]"
                     /db_xref="CDD:211426"
     Site            136
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q01826; propagated from
                     UniProtKB/Swiss-Prot (Q60611.2)"
     Region          139..143
                     /region_name="Protein interaction. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60611.2)"
     Region          176..247
                     /region_name="CUTL"
                     /note="CUT1-like DNA-binding domain of SATB; pfam16557"
                     /db_xref="CDD:435427"
     Site            185
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q01826; propagated from
                     UniProtKB/Swiss-Prot (Q60611.2)"
     Region          224..278
                     /region_name="Nuclear matrix targeting sequence (NMTS)"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60611.2)"
     Region          224..278
                     /region_name="Nuclear matrix targeting sequence (NMTS).
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60611.2)"
     Site            254..255
                     /site_type="cleavage"
                     /note="Cleavage, by caspases; propagated from
                     UniProtKB/Swiss-Prot (Q60611.2)"
     Region          266..307
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60611.2)"
     Region          372..444
                     /region_name="CUT"
                     /note="CUT domain; pfam02376"
                     /db_xref="CDD:426745"
     Region          450..474
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60611.2)"
     Region          497..567
                     /region_name="CUT"
                     /note="CUT domain; pfam02376"
                     /db_xref="CDD:426745"
     Region          591..650
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60611.2)"
     Site            638
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q60611.2)"
     Region          645..702
                     /region_name="HOX"
                     /note="Homeodomain; smart00389"
                     /db_xref="CDD:197696"
     Site            order(647..650,652,670,676,689,691..692,695..696,698..700,
                     702..703)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     Site            order(648,651,692,695..696,699)
                     /site_type="other"
                     /note="specific DNA base contacts [nucleotide binding]"
                     /db_xref="CDD:238039"
     CDS             1..764
                     /gene="Satb1"
                     /gene_synonym="2610306G12Rik"
                     /coded_by="NM_001163632.1:163..2457"
                     /note="isoform 1 is encoded by transcript variant 4"
                     /db_xref="CCDS:CCDS28876.1"
                     /db_xref="GeneID:20230"
                     /db_xref="MGI:MGI:105084"
ORIGIN      
        1 mdhlneatqg kehsemsnnv sdpkgppaki arleqngspl grgrlgstgg kmqgvplkhs
       61 ghlmktnlrk gtmlpvfcvv ehyenaieyd ckeehaefvl vrkdmlfnql iemallslgy
      121 shssaaqakg liqvgkwnpv plsyvtdapd atvadmlqdv yhvvtlkiql hscpkledlp
      181 peqwshttvr nalkdllkdm nqsslakecp lsqsmissiv nstyyanvsa akcqefgrwy
      241 khfkktkdmm vemdslsels qqganhvnfg qqpvpgntae qppspaqlsh gsqpsvrtpl
      301 pnlhpglvst pispqlvnqq lvmaqllnqq yavnrllaqq slnqqylnhp ppvsrsmnkp
      361 leqqvstnte vsseiyqwvr delkragisq avfarvafnr tqgllseilr keedpktasq
      421 sllvnlramq nflqlpeaer driyqderer slnaasamgp apllstppsr ppqvktatla
      481 terngkpenn tmninasiyd eiqqemkrak vsqalfakva atksqgwlce llrwkedpsp
      541 enrtlwenls mirrflslpq perdaiyeqe snavhhhgdr pphiihvpae qiqqqqqqqq
      601 qqqqqqqppp pppqpqpqpq agprlpprqp tvassaesde enrqktrprt kisvealgil
      661 qsfiqdvgly pdeeaiqtls aqldlpkyti ikffqnqryy lkhhgklkdn sglevdvaey
      721 kdeellkdle esvqdknant lfsvkleeel svegstdvna dlkd
//
LOCUS       NP_001368854             657 aa            linear   ROD 09-OCT-2023
DEFINITION  broad substrate specificity ATP-binding cassette transporter ABCG2
            [Mus musculus].
ACCESSION   NP_001368854 XP_006506212
VERSION     NP_001368854.1
DBSOURCE    REFSEQ: accession NM_001381925.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 657)
  AUTHORS   Notsu T, Kurata Y, Ninomiya H, Taufiq F, Komatsu K, Miake J, Sawano
            T, Tsuneto M, Shirayoshi Y and Hisatome I.
  TITLE     Inhibition of the uric acid efflux transporter ABCG2 enhances
            stimulating effect of soluble uric acid on IL-1beta production in
            murine macrophage-like J774.1 cells
  JOURNAL   Hypertens Res 46 (10), 2368-2377 (2023)
   PUBMED   37592041
  REMARK    GeneRIF: Inhibition of the uric acid efflux transporter ABCG2
            enhances stimulating effect of soluble uric acid on IL-1beta
            production in murine macrophage-like J774.1 cells.
REFERENCE   2  (residues 1 to 657)
  AUTHORS   Harby SA, Khalil NA, El-Sayed NS, Thabet EH, Saleh SR and Fathelbab
            MH.
  TITLE     Implications of BCRP modulation on PTZ-induced seizures in mice:
            Role of ko143 and metformin as adjuvants to lamotrigine
  JOURNAL   Naunyn Schmiedebergs Arch Pharmacol 396 (10), 2627-2636 (2023)
   PUBMED   37067582
  REMARK    GeneRIF: Implications of BCRP modulation on PTZ-induced seizures in
            mice: Role of ko143 and metformin as adjuvants to lamotrigine.
REFERENCE   3  (residues 1 to 657)
  AUTHORS   Blanco-Paniagua E, Alvarez-Fernandez L, Rodriguez-Alonso A,
            Millan-Garcia A, Alvarez AI and Merino G.
  TITLE     Role of the Abcg2 Transporter in Secretion into Milk of the
            Anthelmintic Clorsulon: Interaction with Ivermectin
  JOURNAL   Antimicrob Agents Chemother 67 (5), e0009523 (2023)
   PUBMED   37078871
  REMARK    GeneRIF: Role of the Abcg2 Transporter in Secretion into Milk of
            the Anthelmintic Clorsulon: Interaction with Ivermectin.
REFERENCE   4  (residues 1 to 657)
  AUTHORS   Wu C, Xiao Y, Wu C, Xie D, Luo M, Yao D, Chen M and Lu D.
  TITLE     Regulation of BCRP expression and sulfasalazine pharmacokinetics by
            the nuclear receptor REV-ERBalpha
  JOURNAL   Xenobiotica 53 (3), 215-222 (2023)
   PUBMED   37039301
  REMARK    GeneRIF: Regulation of BCRP expression and sulfasalazine
            pharmacokinetics by the nuclear receptor REV-ERBalpha.
REFERENCE   5  (residues 1 to 657)
  AUTHORS   Alvarez-Fernandez L, Gomez-Gomez A, Haro N, Garcia-Lino AM, Alvarez
            AI, Pozo OJ and Merino G.
  TITLE     ABCG2 transporter plays a key role in the biodistribution of
            melatonin and its main metabolites
  JOURNAL   J Pineal Res 74 (2), e12849 (2023)
   PUBMED   36562106
  REMARK    GeneRIF: ABCG2 transporter plays a key role in the biodistribution
            of melatonin and its main metabolites.
REFERENCE   6  (residues 1 to 657)
  AUTHORS   Geschwind DH, Ou J, Easterday MC, Dougherty JD, Jackson RL, Chen Z,
            Antoine H, Terskikh A, Weissman IL, Nelson SF and Kornblum HI.
  TITLE     A genetic analysis of neural progenitor differentiation
  JOURNAL   Neuron 29 (2), 325-339 (2001)
   PUBMED   11239426
REFERENCE   7  (residues 1 to 657)
  AUTHORS   Jonker JW, Smit JW, Brinkhuis RF, Maliepaard M, Beijnen JH,
            Schellens JH and Schinkel AH.
  TITLE     Role of breast cancer resistance protein in the bioavailability and
            fetal penetration of topotecan
  JOURNAL   J Natl Cancer Inst 92 (20), 1651-1656 (2000)
   PUBMED   11036110
REFERENCE   8  (residues 1 to 657)
  AUTHORS   Schriml LM and Dean M.
  TITLE     Identification of 18 mouse ABC genes and characterization of the
            ABC superfamily in Mus musculus
  JOURNAL   Genomics 64 (1), 24-31 (2000)
   PUBMED   10708515
REFERENCE   9  (residues 1 to 657)
  AUTHORS   Allen JD, Brinkhuis RF, Wijnholds J and Schinkel AH.
  TITLE     The mouse Bcrp1/Mxr/Abcp gene: amplification and overexpression in
            cell lines selected for resistance to topotecan, mitoxantrone, or
            doxorubicin
  JOURNAL   Cancer Res 59 (17), 4237-4241 (1999)
   PUBMED   10485464
REFERENCE   10 (residues 1 to 657)
  AUTHORS   Allikmets R, Schriml LM, Hutchinson A, Romano-Spica V and Dean M.
  TITLE     A human placenta-specific ATP-binding cassette gene (ABCP) on
            chromosome 4q22 that is involved in multidrug resistance
  JOURNAL   Cancer Res 58 (23), 5337-5339 (1998)
   PUBMED   9850061
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121855.3 and AC121859.2.
            
            On Apr 20, 2020 this sequence version replaced XP_006506212.1.
            
            Summary: The membrane-associated protein encoded by this gene is
            included in the superfamily of ATP-binding cassette (ABC)
            transporters. ABC proteins transport various molecules across
            extra- and intra-cellular membranes. ABC genes are divided into
            seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,
            White). This protein is a member of the White subfamily.
            Alternatively referred to as a breast cancer resistance protein,
            the human protein functions as a xenobiotic transporter which may
            play a major role in multi-drug resistance. This protein likely
            serves as a cellular defense mechanism in response to mitoxantrone
            and anthracycline exposure. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422591.516871.1,
                                           SRR7345562.2893332.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..657
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 27.82 cM"
     Protein         1..657
                     /product="broad substrate specificity ATP-binding cassette
                     transporter ABCG2"
                     /EC_number="7.6.2.2"
                     /note="mitoxantrone resistance protein 1; ATP-binding
                     cassette sub-family G member 2; breast cancer resistance
                     protein 1 homolog; urate exporter; ATP-binding cassette,
                     sub-family G (WHITE), member 2"
                     /calculated_mol_wt=72891
     Region          1..24
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TMS5.1)"
     Region          46..651
                     /region_name="3a01204"
                     /note="The Eye Pigment Precursor Transporter (EPP) Family
                     protein; TIGR00955"
                     /db_xref="CDD:273361"
     Site            394..414
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TMS5.1)"
     Site            429..449
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TMS5.1)"
     Site            478..498
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TMS5.1)"
     Site            507..527
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TMS5.1)"
     Site            536..556
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TMS5.1)"
     Site            596
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TMS5.1)"
     Site            600
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TMS5.1)"
     Site            633..653
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TMS5.1)"
     CDS             1..657
                     /gene="Abcg2"
                     /gene_synonym="ABC15; ABCP; BCRP; Bcrp1; MXR; MXR1"
                     /coded_by="NM_001381925.1:212..2185"
                     /db_xref="GeneID:26357"
                     /db_xref="MGI:MGI:1347061"
ORIGIN      
        1 msssndhvlv pmsqrnnngl prmnsravrt laegdvlsfh hityrvkvks gflvrktvek
       61 eilsdingim kpglnailgp tgggksslld vlaarkdpkg lsgdvlinga pqpahfkccs
      121 gyvvqddvvm gtltvrenlq fsaalrlptt mknhekneri ntiikelgle kvadskvgtq
      181 firgisgger krtsigmeli tdpsilflde pttgldssta navllllkrm skqgrtiifs
      241 ihqprysifk lfdsltllas gklvfhgpaq kaleyfasag yhcepynnpa dffldvingd
      301 ssavmlnree qdneanktee pskgekpvie nlsefyinsa iygetkaeld qlpgaqekkg
      361 tsafkepvyv tsfchqlrwi arrsfknllg npqasvaqli vtvilgliig aiyfdlkyda
      421 agmqnragvl fflttnqcfs svsavelfvv ekklfiheyi sgyyrvssyf fgkvmsdllp
      481 mrflpsvift cilyfmlglk ktvdaffimm ftlimvayta ssmalaiatg qsvvsvatll
      541 mtiafvfmml fsgllvnlrt igpwlswlqy fsiprygfta lqyneflgqe fcpgfnvtdn
      601 stcvnsyaic tgneylinqg ielspwglwk nhvalacmii ifltiaylkl lflkkys
//
LOCUS       NP_001349222             512 aa            linear   ROD 09-OCT-2023
DEFINITION  CUGBP Elav-like family member 4 isoform 18 [Mus musculus].
ACCESSION   NP_001349222
VERSION     NP_001349222.1
DBSOURCE    REFSEQ: accession NM_001362293.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 512)
  AUTHORS   Salamon I, Park Y, Miskic T, Kopic J, Matteson P, Page NF, Roque A,
            McAuliffe GW, Favate J, Garcia-Forn M, Shah P, Judas M, Millonig
            JH, Kostovic I, De Rubeis S, Hart RP, Krsnik Z and Rasin MR.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    GeneRIF: Celf4 controls mRNA translation underlying synaptic
            development in the prenatal mammalian neocortex.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 512)
  AUTHORS   Shen Y, Zhang C, Xiao K, Liu D and Xie G.
  TITLE     CELF4 regulates spine formation and depression-like behaviors of
            mice
  JOURNAL   Biochem Biophys Res Commun 605, 39-44 (2022)
   PUBMED   35306363
  REMARK    GeneRIF: CELF4 regulates spine formation and depression-like
            behaviors of mice.
REFERENCE   3  (residues 1 to 512)
  AUTHORS   Moreau MX, Saillour Y, Cwetsch AW, Pierani A and Causeret F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   4  (residues 1 to 512)
  AUTHORS   Li C, Li X, Bi Z, Sugino K, Wang G, Zhu T and Liu Z.
  TITLE     Comprehensive transcriptome analysis of cochlear spiral ganglion
            neurons at multiple ages
  JOURNAL   Elife 9, e50491 (2020)
   PUBMED   31913118
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 512)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 512)
  AUTHORS   Ladd AN, Taffet G, Hartley C, Kearney DL and Cooper TA.
  TITLE     Cardiac tissue-specific repression of CELF activity disrupts
            alternative splicing and causes cardiomyopathy
  JOURNAL   Mol Cell Biol 25 (14), 6267-6278 (2005)
   PUBMED   15988035
  REMARK    GeneRIF: CELF protein activity is required for normal alternative
            splicing in the heart in vivo and normal CELF-mediated alternative
            splicing regulation is in turn required for normal cardiac
            function.
REFERENCE   7  (residues 1 to 512)
  AUTHORS   Meins M, Schlickum S, Wilhelm C, Missbach J, Yadav S, Glaser B,
            Grzmil M, Burfeind P and Laccone F.
  TITLE     Identification and characterization of murine Brunol4, a new member
            of the elav/bruno family
  JOURNAL   Cytogenet Genome Res 97 (3-4), 254-260 (2002)
   PUBMED   12438720
  REMARK    GeneRIF: cloning and characterization
REFERENCE   8  (residues 1 to 512)
  AUTHORS   Ladd AN, Charlet N and Cooper TA.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   9  (residues 1 to 512)
  AUTHORS   Good PJ, Chen Q, Warner SJ and Herring DC.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
REFERENCE   10 (residues 1 to 512)
  AUTHORS   Yulug IG, Egan SE, See CG and Fisher EM.
  TITLE     Mapping GRB2, a signal transduction gene in the human and the mouse
  JOURNAL   Genomics 22 (2), 313-318 (1994)
   PUBMED   7806216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121094.8 and AC144938.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164131,
                              SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 13.92 cM"
     Protein         1..512
                     /product="CUGBP Elav-like family member 4 isoform 18"
                     /note="CUG-BP- and ETR-3-like factor 4; bruno-like protein
                     4; RNA-binding protein BRUNOL-4; bruno-like 4, RNA binding
                     protein"
                     /calculated_mol_wt=54533
     Region          49..135
                     /region_name="RRM1_CELF3_4_5_6"
                     /note="RNA recognition motif 1 (RRM1) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12632"
                     /db_xref="CDD:410041"
     Site            order(55,57,59..60,63,82,84,86,95..97,99,129,131)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410041"
     Region          140..220
                     /region_name="RRM2_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12635"
                     /db_xref="CDD:410043"
     Site            order(142,144,146..147,150,169,171,173,181..183,185,215,
                     217)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410043"
     Region          378..>422
                     /region_name="RRM_SF"
                     /note="RNA recognition motif (RRM) superfamily; cl17169"
                     /db_xref="CDD:450164"
     CDS             1..512
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /coded_by="NM_001362293.1:531..2069"
                     /note="isoform 18 is encoded by transcript variant 24"
                     /db_xref="GeneID:108013"
                     /db_xref="MGI:MGI:1932407"
ORIGIN      
        1 myikmatlan gqadnaslst nglgsspgsa ghmnglshsp gnpstipmkd hdaiklfigq
       61 iprnldekdl kplfeefgki yeltvlkdrf tgmhkgcafl tyceresalk aqsalheqkt
      121 lpgmnrpiqv kpadsesrgd rklfvgmlnk qqseddvrrl feafgnieec tilrgpdgns
      181 kgcafvkyss haeaqaaina lhgsqtmpga ssslvvkfad tdkertmrrm qqmagqmgmf
      241 npmaipfgay gayaqamqqq aalmasvaqg gylnpmaafa aaqmqqmaal nmnglaaapm
      301 tptsggstpp gitapavpsi pspigvngft glppqangqp aaeavfangi hpypaqspta
      361 adplqqayag vqqyagrpeg cnlliyhlpq efgdaelmqm flpfgnviss kvfvdratnq
      421 srhpvpsrcq apscqggqca isssarrlre lrqpgqrtdr hpgherlpdr heeaqgaaea
      481 aqrrqspvls aggsvprgrp glaqgrmlng lh
//
LOCUS       NP_084063                301 aa            linear   ROD 09-OCT-2023
DEFINITION  NADH-cytochrome b5 reductase 3 [Mus musculus].
ACCESSION   NP_084063
VERSION     NP_084063.1
DBSOURCE    REFSEQ: accession NM_029787.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 301)
  AUTHORS   Sanchez-Mendoza LM, Perez-Sanchez C, Rodriguez-Lopez S,
            Lopez-Pedrera C, Calvo-Rubio M, de Cabo R, Buron MI, Gonzalez-Reyes
            JA and Villalba JM.
  TITLE     Sex-specific metabolic adaptations in transgenic mice
            overexpressing cytochrome b5 reductase-3
  JOURNAL   Free Radic Biol Med 207, 144-160 (2023)
   PUBMED   37463636
  REMARK    GeneRIF: Sex-specific metabolic adaptations in transgenic mice
            overexpressing cytochrome b5 reductase-3.
REFERENCE   2  (residues 1 to 301)
  AUTHORS   Bueno M, Calyeca J, Khaliullin T, Miller MP, Alvarez D, Rosas L,
            Brands J, Baker C, Nasser A, Shulkowski S, Mathien A, Uzoukwu N,
            Sembrat J, Mays BG, Fiedler K, Hahn SA, Salvatore SR, Schopfer FJ,
            Rojas M, Sandner P, Straub AC and Mora AL.
  TITLE     CYB5R3 in type II alveolar epithelial cells protects against lung
            fibrosis by suppressing TGF-beta1 signaling
  JOURNAL   JCI Insight 8 (5), e161487 (2023)
   PUBMED   36749633
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 301)
  AUTHORS   Watanabe H, Du W, Son J, Sui L, Asahara SI, Kurland IJ, Kuo T,
            Kitamoto T, Miyachi Y, de Cabo R and Accili D.
  TITLE     Cyb5r3-based mechanism and reversal of secondary failure to
            sulfonylurea in diabetes
  JOURNAL   Sci Transl Med 15 (681), eabq4126 (2023)
   PUBMED   36724243
  REMARK    GeneRIF: Cyb5r3-based mechanism and reversal of secondary failure
            to sulfonylurea in diabetes.
REFERENCE   4  (residues 1 to 301)
  AUTHORS   Ishimura R, El-Gowily AH, Noshiro D, Komatsu-Hirota S, Ono Y,
            Shindo M, Hatta T, Abe M, Uemura T, Lee-Okada HC, Mohamed TM,
            Yokomizo T, Ueno T, Sakimura K, Natsume T, Sorimachi H, Inada T,
            Waguri S, Noda NN and Komatsu M.
  TITLE     The UFM1 system regulates ER-phagy through the ufmylation of CYB5R3
  JOURNAL   Nat Commun 13 (1), 7857 (2022)
   PUBMED   36543799
  REMARK    GeneRIF: The UFM1 system regulates ER-phagy through the ufmylation
            of CYB5R3.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 301)
  AUTHORS   Yuan S, Hahn SA, Miller MP, Sanker S, Calderon MJ, Sullivan M,
            Dosunmu-Ogunbi AM, Fazzari M, Li Y, Reynolds M, Wood KC, St Croix
            CM, Stolz D, Cifuentes-Pagano E, Navas P, Shiva S, Schopfer FJ,
            Pagano PJ and Straub AC.
  TITLE     Cooperation between CYB5R3 and NOX4 via coenzyme Q mitigates
            endothelial inflammation
  JOURNAL   Redox Biol 47, 102166 (2021)
   PUBMED   34656824
  REMARK    GeneRIF: Cooperation between CYB5R3 and NOX4 via coenzyme Q
            mitigates endothelial inflammation.
REFERENCE   6  (residues 1 to 301)
  AUTHORS   Yoshida T and Tsuda H.
  TITLE     Gene targeting of DT-diaphorase in mouse embryonic stem cells:
            establishment of null mutant and its mitomycin C-resistance
  JOURNAL   Biochem Biophys Res Commun 214 (2), 701-708 (1995)
   PUBMED   7677784
REFERENCE   7  (residues 1 to 301)
  AUTHORS   Hawkes R and Turner RW.
  TITLE     Compartmentation of NADPH-diaphorase activity in the mouse
            cerebellar cortex
  JOURNAL   J Comp Neurol 346 (4), 499-516 (1994)
   PUBMED   7527060
REFERENCE   8  (residues 1 to 301)
  AUTHORS   Bucan M, Gatalica B, Nolan P, Chung A, Leroux A, Grossman MH,
            Nadeau JH, Emanuel BS and Budarf M.
  TITLE     Comparative mapping of 9 human chromosome 22q loci in the
            laboratory mouse
  JOURNAL   Hum Mol Genet 2 (8), 1245-1252 (1993)
   PUBMED   8401507
REFERENCE   9  (residues 1 to 301)
  AUTHORS   Francke,U., Tetri,P., Taggart,R.T. and Oliver,N.
  TITLE     Conserved autosomal syntenic group on mouse (MMU) chromosome 15 and
            human (HSA) chromosome 22: assignment of a gene for arylsulfatase A
            to MMU 15 and regional mapping of DIA1, ARSA, and ACO2 on HSA 22
  JOURNAL   Cytogenet Cell Genet 31 (2), 58-69 (1981)
   PUBMED   6118238
REFERENCE   10 (residues 1 to 301)
  AUTHORS   Taggart,R.T., Tetri,P. and Francke,U.
  TITLE     Assignment of the gene for NADH diaphorase Dia-1 to Mouse
            chromosome 15
  JOURNAL   Somatic Cell Genet 6 (6), 769-776 (1980)
   PUBMED   6893763
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC043074.1 and AI839369.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC004760.2, BC043074.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..301
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 39.4 cM"
     Protein         1..301
                     /product="NADH-cytochrome b5 reductase 3"
                     /EC_number="1.6.2.2"
                     /note="diaphorase 1 (NADH)"
                     /calculated_mol_wt=33997
     Region          <14..301
                     /region_name="PLN02252"
                     /note="nitrate reductase [NADPH]"
                     /db_xref="CDD:215141"
     Site            42
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753,
                     ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (Q9DCN2.3)"
     Site            43
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P00387; propagated from
                     UniProtKB/Swiss-Prot (Q9DCN2.3)"
     Site            50
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (Q9DCN2.3)"
     Site            120
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:16916647; propagated from
                     UniProtKB/Swiss-Prot (Q9DCN2.3)"
     CDS             1..301
                     /gene="Cyb5r3"
                     /gene_synonym="0610016L08Rik; 2500002N19Rik; B5R; Dia-1;
                     Dia1; WU:Cyb5r3"
                     /coded_by="NM_029787.3:52..957"
                     /db_xref="CCDS:CCDS27698.1"
                     /db_xref="GeneID:109754"
                     /db_xref="MGI:MGI:94893"
ORIGIN      
        1 mgaqlstlsh vvlspvwfiy slfmklfqrs tpaitlenpd ikyplrlidk evispdtrrf
       61 rfalpspqhi lglpigqhiy lstridgnlv irpytpvssd ddkgfvdlvv kvyfkdthpk
      121 fpaggkmsqy lenmkigdti efrgpngllv yqgkgkfair adkksnpvvr tvksvgmiag
      181 gtgitpmlqv iravlkdpnd htvcyllfan qsekdillrp eleelrnehs arfklwytvd
      241 kapdawdysq gfvneemird hlptpgeepl ilmcgpppmi qfaclpnler vghpkercft
      301 f
//
LOCUS       NP_001281073            1168 aa            linear   ROD 09-OCT-2023
DEFINITION  homeodomain-interacting protein kinase 2 isoform 4 [Mus musculus].
ACCESSION   NP_001281073 XP_006505668
VERSION     NP_001281073.1
DBSOURCE    REFSEQ: accession NM_001294144.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1168)
  AUTHORS   Wang G, Ma Z, Song C, Wang X and Zhou Z.
  TITLE     miR-147b is an oncomiR acting synergistically with HIPK2 to promote
            pancreatic carcinogenesis
  JOURNAL   Cell Signal 111, 110840 (2023)
   PUBMED   37543099
  REMARK    GeneRIF: miR-147b is an oncomiR acting synergistically with HIPK2
            to promote pancreatic carcinogenesis.
REFERENCE   2  (residues 1 to 1168)
  AUTHORS   Zhong W, Hong C, Dong Y, Li Y, Xiao C and Liu X.
  TITLE     ASH2L Aggravates Fibrosis and Inflammation through HIPK2 in High
            Glucose-Induced Glomerular Mesangial Cells
  JOURNAL   Genes (Basel) 13 (12), 2244 (2022)
   PUBMED   36553510
  REMARK    GeneRIF: ASH2L Aggravates Fibrosis and Inflammation through HIPK2
            in High Glucose-Induced Glomerular Mesangial Cells.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1168)
  AUTHORS   Zhou Q, Meng D, Li F, Zhang X, Liu L, Zhu Y, Liu S, Xu M, Deng J,
            Lei Z, Sluijter JPG and Xiao J.
  TITLE     Inhibition of HIPK2 protects stress-induced pathological cardiac
            remodeling
  JOURNAL   EBioMedicine 85, 104274 (2022)
   PUBMED   36182775
  REMARK    GeneRIF: Inhibition of HIPK2 protects stress-induced pathological
            cardiac remodeling.
REFERENCE   4  (residues 1 to 1168)
  AUTHORS   Cheung KL, Jaganathan A, Hu Y, Xu F, Lejeune A, Sharma R, Caescu
            CI, Meslamani J, Vincek A, Zhang F, Lee K, Zaware N, Qayum AA, Ren
            C, Kaplan MH, He JC, Xiong H and Zhou MM.
  TITLE     HIPK2 directs cell type-specific regulation of STAT3
            transcriptional activity in Th17 cell differentiation
  JOURNAL   Proc Natl Acad Sci U S A 119 (14), e2117112119 (2022)
   PUBMED   35344430
  REMARK    GeneRIF: HIPK2 directs cell type-specific regulation of STAT3
            transcriptional activity in Th17 cell differentiation.
REFERENCE   5  (residues 1 to 1168)
  AUTHORS   Yu Q, Liu L, Zhang X, Chang H, Ma S, Xie Z, Tang S, Ju X, Zhu H,
            Shen B and Zhang Q.
  TITLE     MiR-221-3p targets HIPK2 to promote diabetic wound healing
  JOURNAL   Microvasc Res 140, 104306 (2022)
   PUBMED   34973299
  REMARK    GeneRIF: MiR-221-3p targets HIPK2 to promote diabetic wound
            healing.
REFERENCE   6  (residues 1 to 1168)
  AUTHORS   Hofmann TG, Mincheva A, Lichter P, Droge W and Schmitz ML.
  TITLE     Human homeodomain-interacting protein kinase-2 (HIPK2) is a member
            of the DYRK family of protein kinases and maps to chromosome
            7q32-q34
  JOURNAL   Biochimie 82 (12), 1123-1127 (2000)
   PUBMED   11120354
REFERENCE   7  (residues 1 to 1168)
  AUTHORS   Wang W, Link V and Green JM.
  TITLE     Identification and cloning of a CD43-associated serine/threonine
            kinase
  JOURNAL   Cell Immunol 205 (1), 34-39 (2000)
   PUBMED   11078605
REFERENCE   8  (residues 1 to 1168)
  AUTHORS   Ebling FJ, Brooks AN, Cronin AS, Ford H and Kerr JB.
  TITLE     Estrogenic induction of spermatogenesis in the hypogonadal mouse
  JOURNAL   Endocrinology 141 (8), 2861-2869 (2000)
   PUBMED   10919273
REFERENCE   9  (residues 1 to 1168)
  AUTHORS   Kim YH, Choi CY and Kim Y.
  TITLE     Covalent modification of the homeodomain-interacting protein kinase
            2 (HIPK2) by the ubiquitin-like protein SUMO-1
  JOURNAL   Proc Natl Acad Sci U S A 96 (22), 12350-12355 (1999)
   PUBMED   10535925
REFERENCE   10 (residues 1 to 1168)
  AUTHORS   Kim YH, Choi CY, Lee SJ, Conti MA and Kim Y.
  TITLE     Homeodomain-interacting protein kinases, a novel family of
            co-repressors for homeodomain transcription factors
  JOURNAL   J Biol Chem 273 (40), 25875-25879 (1998)
   PUBMED   9748262
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154016.2, AC118613.8 and AC161147.6.
            
            On Jun 25, 2014 this sequence version replaced XP_006505668.1.
            
            Transcript Variant: This variant (4) uses two alternate in-frame
            splice sites in the coding region compared to variant 2. The
            encoded isoform (4) is shorter than isoform 2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784650.967530.1,
                                           SRR17784645.92735.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1168
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 17.85 cM"
     Protein         1..1168
                     /product="homeodomain-interacting protein kinase 2 isoform
                     4"
                     /EC_number="2.7.11.1"
                     /note="nuclear body-associated kinase 1; sialophorin
                     tail-associated nuclear serine/threonine-protein kinase"
                     /calculated_mol_wt=127417
     Region          183..537
                     /region_name="STKc_HIPK2"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     Homeodomain-Interacting Protein Kinase 2; cd14227"
                     /db_xref="CDD:271129"
     Site            order(205..209,213,226,228,242,261,277..280,283,285..286,
                     324,326,328..329,331,346,349,359,361..364,366,403)
                     /site_type="active"
                     /db_xref="CDD:271129"
     Site            order(205..209,213,226,228,261,277..280,283,324,326,
                     328..329,331,346)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271129"
     Site            order(242,285,324,326,349,359,361..364,366,403)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:271129"
     Site            345..366
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:271129"
     CDS             1..1168
                     /gene="Hipk2"
                     /gene_synonym="1110014O20Rik; B230339E18Rik; Stank"
                     /coded_by="NM_001294144.1:374..3880"
                     /note="isoform 4 is encoded by transcript variant 4"
                     /db_xref="CCDS:CCDS80526.1"
                     /db_xref="GeneID:15258"
                     /db_xref="MGI:MGI:1314872"
ORIGIN      
        1 mapvyegmas hvqvfsphtl qssafcsvkk lkvepssnwd mtgygshskv ysqsknipps
       61 qpasttvsts lpipnpslpy eqtiifpgst ghivvtsass tsvtgqvlgg phnlmrrstv
      121 slldtyqkcg lkrkseeien tssvqiieeh ppmiqnnasg atvatattst atsknsgsns
      181 egdyqlvqhe vlcsmtntye vleflgrgtf gqvvkcwkrg tneivaikil knhpsyarqg
      241 qievsilarl stesaddynf vrayecfqhk nhtclvfeml eqnlydflkq nkfsplplky
      301 irpvlqqvat almklkslgl ihadlkpeni mlvdpsrqpy rvkvidfgsa shvskavcst
      361 ylqsryyrap eiilglpfce aidmwslgcv iaelflgwpl ypgaseydqi ryisqtqglp
      421 aeyllsagtk ttrffnrdtd spyplwrlkt pddheaetgi kskearkyif nclddmaqvn
      481 mttdlegsdm lvekadrref idllkkmlti dadkrvtpie tlnhpfvtmt hlldfphsah
      541 vkscfqnmei ckrrvnmydt vnqsktpfit hvapststnl tmtfnnqltt vhnqpsaasm
      601 aavaprsmpl qtgtaqicar pdpfqqaliv cppgfqglqa spskhagysv rmenavpivt
      661 qapgaqplqi qpgllaqawp ggaqqillpp awqqltgvat htsvqhaavi petmagtqql
      721 adwrnthahg shynpimqqp alltghvtlp aaqplnvgva hvmrqqptst tssrkskqhq
      781 ssvrnvstce vtssqaissp qrskrvkent pprcamvhss pacstsvtcg wgdvassttr
      841 erqrqtivip dtpsptvsvi tissdtdeee eqkhaptstv skqrknvisc vtvhdspysd
      901 sssntspysv qqrtghngtn tldtkgglen hctgnprtii vpplktqase vlvecdslgp
      961 aisashhsss fkskssstvt stsghssgss sgaiayrqqr pgphfqqqqp lnlsqaqqhm
     1021 aadrtgshrr qqayitptma qapytfphns pshgtvhphl aaaahlptqp hlytytapta
     1081 lgstgtvahl vasqgsarht vqhtaypasi vhqvpvsmgp rvlpsptihp sqypaqfahq
     1141 tyisaspast vytgyplspa kvnqypyi
//
LOCUS       NP_997563                196 aa            linear   ROD 09-OCT-2023
DEFINITION  bcl-2-like protein 11 isoform 1 [Mus musculus].
ACCESSION   NP_997563
VERSION     NP_997563.1
DBSOURCE    REFSEQ: accession NM_207680.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 196)
  AUTHORS   Jiang M, Wang XB and Jiang S.
  TITLE     circ_0000018 downregulation peripherally ameliorates
            neuroprotection against acute ischemic stroke through the
            miR-871/BCL2L11 axis
  JOURNAL   Mol Med Rep 28 (5) (2023)
   PUBMED   37772397
  REMARK    GeneRIF: circ_0000018 downregulation peripherally ameliorates
            neuroprotection against acute ischemic stroke through the
            miR-871/BCL2L11 axis.
REFERENCE   2  (residues 1 to 196)
  AUTHORS   Lu Y, Tang K, Wang S, Tian Z, Fan Y, Li B, Wang M, Zhao J and Xie
            J.
  TITLE     Dach1 deficiency drives alveolar epithelium apoptosis in pulmonary
            fibrosis via modulating C-Jun/Bim activity
  JOURNAL   Transl Res 257, 54-65 (2023)
   PUBMED   36754276
  REMARK    GeneRIF: Dach1 deficiency drives alveolar epithelium apoptosis in
            pulmonary fibrosis via modulating C-Jun/Bim activity.
REFERENCE   3  (residues 1 to 196)
  AUTHORS   Nguyen HV, Vandenberg CJ, Robati MR, Ng AP and Cory S.
  TITLE     MNT suppresses T cell apoptosis via BIM and is critical for T
            lymphomagenesis
  JOURNAL   Cell Death Differ 30 (4), 1018-1032 (2023)
   PUBMED   36755068
  REMARK    GeneRIF: MNT suppresses T cell apoptosis via BIM and is critical
            for T lymphomagenesis.
REFERENCE   4  (residues 1 to 196)
  AUTHORS   Chen H, Bai Y, Kobayashi M, Xiao S, Cai W, Barajas S, Chen S, Miao
            J, Meke FN, Vemula S, Ropa JP, Croop JM, Boswell HS, Wan J, Jia Y,
            Liu H, Li LS, Altman JK, Eklund EA, Ji P, Tong W, Band H, Huang DT,
            Platanias LC, Zhang ZY and Liu Y.
  TITLE     PRL2 phosphatase enhances oncogenic FLT3 signaling via
            dephosphorylation of the E3 ubiquitin ligase CBL at tyrosine 371
  JOURNAL   Blood 141 (3), 244-259 (2023)
   PUBMED   36206490
REFERENCE   5  (residues 1 to 196)
  AUTHORS   Brahma MK, Xiao P, Popa M, Negueruela J, Vandenbempt V, Demine S,
            Cardozo AK and Gurzov EN.
  TITLE     Nova1 or Bim Deficiency in Pancreatic beta-Cells Does Not Alter
            Multiple Low-Dose Streptozotocin-Induced Diabetes and Diet-Induced
            Obesity in Mice
  JOURNAL   Nutrients 14 (18), 3866 (2022)
   PUBMED   36145242
  REMARK    GeneRIF: Nova1 or Bim Deficiency in Pancreatic beta-Cells Does Not
            Alter Multiple Low-Dose Streptozotocin-Induced Diabetes and
            Diet-Induced Obesity in Mice.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 196)
  AUTHORS   Bouillet P, Zhang LC, Huang DC, Webb GC, Bottema CD, Shore P, Eyre
            HJ, Sutherland GR and Adams JM.
  TITLE     Gene structure alternative splicing, and chromosomal localization
            of pro-apoptotic Bcl-2 relative Bim
  JOURNAL   Mamm Genome 12 (2), 163-168 (2001)
   PUBMED   11210187
REFERENCE   7  (residues 1 to 196)
  AUTHORS   Bouillet P, Metcalf D, Huang DC, Tarlinton DM, Kay TW, Kontgen F,
            Adams JM and Strasser A.
  TITLE     Proapoptotic Bcl-2 relative Bim required for certain apoptotic
            responses, leukocyte homeostasis, and to preclude autoimmunity
  JOURNAL   Science 286 (5445), 1735-1738 (1999)
   PUBMED   10576740
REFERENCE   8  (residues 1 to 196)
  AUTHORS   Puthalakath H, Huang DC, O'Reilly LA, King SM and Strasser A.
  TITLE     The proapoptotic activity of the Bcl-2 family member Bim is
            regulated by interaction with the dynein motor complex
  JOURNAL   Mol Cell 3 (3), 287-296 (1999)
   PUBMED   10198631
REFERENCE   9  (residues 1 to 196)
  AUTHORS   Reed JC.
  TITLE     Bcl-2 family proteins
  JOURNAL   Oncogene 17 (25), 3225-3236 (1998)
   PUBMED   9916985
  REMARK    Review article
REFERENCE   10 (residues 1 to 196)
  AUTHORS   O'Connor L, Strasser A, O'Reilly LA, Hausmann G, Adams JM, Cory S
            and Huang DC.
  TITLE     Bim: a novel member of the Bcl-2 family that promotes apoptosis
  JOURNAL   EMBO J 17 (2), 384-395 (1998)
   PUBMED   9430630
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK037885.1, AK082613.1, CB521709.1, CA321725.1, AA881651.1 and
            BE136124.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK082613.1, AK011490.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..196
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 62.23 cM"
     Protein         1..196
                     /product="bcl-2-like protein 11 isoform 1"
                     /note="bcl-2-like protein 11; bcl2-interacting mediator of
                     cell death; Bcl2 interacting mediator of cell death;
                     BCL2-like 11 (apoptosis facilitator)"
                     /calculated_mol_wt=21936
     Region          1..68
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O54918.1)"
     Region          4..40
                     /region_name="Bim_N"
                     /note="Bim protein N-terminus; pfam06773"
                     /db_xref="CDD:429111"
     Site            65
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by MAPK.
                     /evidence=ECO:0000269|PubMed:21478148,
                     ECO:0000269|PubMed:27013495; propagated from
                     UniProtKB/Swiss-Prot (O54918.1)"
     Site            73
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O88498; propagated from
                     UniProtKB/Swiss-Prot (O54918.1)"
     Site            83
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O88498; propagated from
                     UniProtKB/Swiss-Prot (O54918.1)"
     Site            90
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O43521; propagated from
                     UniProtKB/Swiss-Prot (O54918.1)"
     Region          129..164
                     /region_name="Bclx_interact"
                     /note="Bcl-x interacting, BH3 domain; pfam08945"
                     /db_xref="CDD:430337"
     Region          146..160
                     /region_name="BH3"
                     /note="propagated from UniProtKB/Swiss-Prot (O54918.1)"
     CDS             1..196
                     /gene="Bcl2l11"
                     /gene_synonym="1500006F24Rik; bcl2-L-11; Bim; Bod"
                     /coded_by="NM_207680.2:229..819"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS16713.1"
                     /db_xref="GeneID:12125"
                     /db_xref="MGI:MGI:1197519"
ORIGIN      
        1 makqpsdvss ecdreggqlq paerppqlrp gaptslqtep qgnpdgegdr cphgspqgpl
       61 appaspgpfa trsplfifvr rssllsrsss gyfsfdtdrs papmscdkst qtpsppcqaf
      121 nhylsamasi rqsqeepedl rpeiriaqel rrigdefnet ytrrvfandy reaedhpqmv
      181 ilqllrfifr lvwrrh
//
LOCUS       NP_076006                241 aa            linear   ROD 09-OCT-2023
DEFINITION  tumor necrosis factor ligand superfamily member 13 isoform 1 [Mus
            musculus].
ACCESSION   NP_076006
VERSION     NP_076006.2
DBSOURCE    REFSEQ: accession NM_023517.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 241)
  AUTHORS   Doll JR, Moreno-Fernandez ME, Stankiewicz TE, Wayland JL, Wilburn
            A, Weinhaus B, Chougnet CA, Giordano D, Cappelletti M, Presicce P,
            Kallapur SG, Salomonis N, Tilburgs T and Divanovic S.
  TITLE     BAFF and APRIL counterregulate susceptibility to
            inflammation-induced preterm birth
  JOURNAL   Cell Rep 42 (4), 112352 (2023)
   PUBMED   37027297
  REMARK    GeneRIF: BAFF and APRIL counterregulate susceptibility to
            inflammation-induced preterm birth.
REFERENCE   2  (residues 1 to 241)
  AUTHORS   Sturm N, Roger-Margueritat M, Pierrel F, Lehours P, Genevay M and
            Huard B.
  TITLE     Spatial heterogeneity for APRIL production by eosinophils in the
            small intestine
  JOURNAL   J Leukoc Biol 113 (4), 376-382 (2023)
   PUBMED   36808499
  REMARK    GeneRIF: Spatial heterogeneity for APRIL production by eosinophils
            in the small intestine.
REFERENCE   3  (residues 1 to 241)
  AUTHORS   Tsiantoulas D, Eslami M, Obermayer G, Clement M, Smeets D, Mayer
            FJ, Kiss MG, Enders L, Weisser J, Goderle L, Lambert J, Frommlet F,
            Mueller A, Hendrikx T, Ozsvar-Kozma M, Porsch F, Willen L,
            Afonyushkin T, Murphy JE, Fogelstrand P, Donze O, Pasterkamp G,
            Hoke M, Kubicek S, Jorgensen HF, Danchin N, Simon T, Scharnagl H,
            Marz W, Boren J, Hess H, Mallat Z, Schneider P and Binder CJ.
  TITLE     APRIL limits atherosclerosis by binding to heparan sulfate
            proteoglycans
  JOURNAL   Nature 597 (7874), 92-96 (2021)
   PUBMED   34433968
REFERENCE   4  (residues 1 to 241)
  AUTHORS   Chan CC, Harley ITW, Pfluger PT, Trompette A, Stankiewicz TE, Allen
            JL, Moreno-Fernandez ME, Damen MSMA, Oates JR, Alarcon PC, Doll JR,
            Flick MJ, Flick LM, Sanchez-Gurmaches J, Mukherjee R, Karns R,
            Helmrath M, Inge TH, Weisberg SP, Pamp SJ, Relman DA, Seeley RJ,
            Tschop MH, Karp CL and Divanovic S.
  TITLE     A BAFF/APRIL axis regulates obesogenic diet-driven weight gain
  JOURNAL   Nat Commun 12 (1), 2911 (2021)
   PUBMED   34006859
  REMARK    GeneRIF: A BAFF/APRIL axis regulates obesogenic diet-driven weight
            gain.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 241)
  AUTHORS   Benet Z, Jing Z and Fooksman DR.
  TITLE     Plasma cell dynamics in the bone marrow niche
  JOURNAL   Cell Rep 34 (6), 108733 (2021)
   PUBMED   33567286
REFERENCE   6  (residues 1 to 241)
  AUTHORS   Varfolomeev E, Kischkel F, Martin F, Seshasayee D, Wang H, Lawrence
            D, Olsson C, Tom L, Erickson S, French D, Schow P, Grewal IS and
            Ashkenazi A.
  TITLE     APRIL-deficient mice have normal immune system development
  JOURNAL   Mol Cell Biol 24 (3), 997-1006 (2004)
   PUBMED   14729948
REFERENCE   7  (residues 1 to 241)
  AUTHORS   MacLennan I and Vinuesa C.
  TITLE     Dendritic cells, BAFF, and APRIL: innate players in adaptive
            antibody responses
  JOURNAL   Immunity 17 (3), 235-238 (2002)
   PUBMED   12354377
  REMARK    GeneRIF: Review. Dendritic cell-derived TNF-family ligand APRIL
            enhances plasmablast survival and differentiation to plasma cells.
            Review article
REFERENCE   8  (residues 1 to 241)
  AUTHORS   Stein JV, Lopez-Fraga M, Elustondo FA, Carvalho-Pinto CE, Rodriguez
            D, Gomez-Caro R, De Jong J, Martinez-A C, Medema JP and Hahne M.
  TITLE     APRIL modulates B and T cell immunity
  JOURNAL   J Clin Invest 109 (12), 1587-1598 (2002)
   PUBMED   12070306
REFERENCE   9  (residues 1 to 241)
  AUTHORS   Locksley RM, Killeen N and Lenardo MJ.
  TITLE     The TNF and TNF receptor superfamilies: integrating mammalian
            biology
  JOURNAL   Cell 104 (4), 487-501 (2001)
   PUBMED   11239407
  REMARK    Review article
REFERENCE   10 (residues 1 to 241)
  AUTHORS   Yu G, Boone T, Delaney J, Hawkins N, Kelley M, Ramakrishnan M,
            McCabe S, Qiu WR, Kornuc M, Xia XZ, Guo J, Stolina M, Boyle WJ,
            Sarosi I, Hsu H, Senaldi G and Theill LE.
  TITLE     APRIL and TALL-I and receptors BCMA and TACI: system for regulating
            humoral immunity
  JOURNAL   Nat Immunol 1 (3), 252-256 (2000)
   PUBMED   10973284
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK009514.1, AK134028.1 and BY463961.1.
            
            On Oct 13, 2005 this sequence version replaced NP_076006.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK009514.1, BC069900.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..241
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.86 cM"
     Protein         1..241
                     /product="tumor necrosis factor ligand superfamily member
                     13 isoform 1"
                     /note="a proliferation-inducing ligand; tumor necrosis
                     factor ligand 7b"
                     /calculated_mol_wt=26758
     Site            95..96
                     /site_type="cleavage"
                     /note="Cleavage, by furin. /evidence=ECO:0000250;
                     propagated from UniProtKB/Swiss-Prot (Q9D777.1)"
     Region          108..239
                     /region_name="TNF"
                     /note="Tumor Necrosis Factor; TNF superfamily members
                     include the cytokines: TNF (TNF-alpha), LT
                     (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL),
                     Fas ligand, and osteoprotegerin (OPG) ligand. These
                     proteins generally have an intracellular N-terminal...;
                     cd00184"
                     /db_xref="CDD:238108"
     Site            order(110,155,157,203,208,235,239)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:238108"
     Site            115
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9D777.1)"
     Site            order(130..131,136,170,177,182)
                     /site_type="active"
                     /note="receptor binding sites [active]"
                     /db_xref="CDD:238108"
     CDS             1..241
                     /gene="Tnfsf13"
                     /gene_synonym="2310026N09Rik; April; Tall2; Tnlg7b; Trdl1"
                     /coded_by="NM_023517.2:296..1021"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:69583"
                     /db_xref="MGI:MGI:1916833"
ORIGIN      
        1 mpasspghmg gsvrepalsv alwlswgavl gavtcavall iqqtelqslr revsrlqrsg
       61 gpsqkqgerp wqslweqspd vleawkdgak srrrravltq khkkkhsvlh lvpvnitska
      121 dsdvtevmwq pvlrrgrgle aqgdivrvwd tgiyllysqv lfhdvtftmg qvvsregqgr
      181 retlfrcirs mpsdpdrayn scysagvfhl hqgdiitvki pranaklsls phgtflgfvk
      241 l
//
LOCUS       NP_001349254             476 aa            linear   ROD 09-OCT-2023
DEFINITION  CUGBP Elav-like family member 4 isoform 43 [Mus musculus].
ACCESSION   NP_001349254 XP_017173286
VERSION     NP_001349254.1
DBSOURCE    REFSEQ: accession NM_001362325.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 476)
  AUTHORS   Salamon I, Park Y, Miskic T, Kopic J, Matteson P, Page NF, Roque A,
            McAuliffe GW, Favate J, Garcia-Forn M, Shah P, Judas M, Millonig
            JH, Kostovic I, De Rubeis S, Hart RP, Krsnik Z and Rasin MR.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    GeneRIF: Celf4 controls mRNA translation underlying synaptic
            development in the prenatal mammalian neocortex.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 476)
  AUTHORS   Shen Y, Zhang C, Xiao K, Liu D and Xie G.
  TITLE     CELF4 regulates spine formation and depression-like behaviors of
            mice
  JOURNAL   Biochem Biophys Res Commun 605, 39-44 (2022)
   PUBMED   35306363
  REMARK    GeneRIF: CELF4 regulates spine formation and depression-like
            behaviors of mice.
REFERENCE   3  (residues 1 to 476)
  AUTHORS   Moreau MX, Saillour Y, Cwetsch AW, Pierani A and Causeret F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   4  (residues 1 to 476)
  AUTHORS   Li C, Li X, Bi Z, Sugino K, Wang G, Zhu T and Liu Z.
  TITLE     Comprehensive transcriptome analysis of cochlear spiral ganglion
            neurons at multiple ages
  JOURNAL   Elife 9, e50491 (2020)
   PUBMED   31913118
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 476)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 476)
  AUTHORS   Ladd AN, Taffet G, Hartley C, Kearney DL and Cooper TA.
  TITLE     Cardiac tissue-specific repression of CELF activity disrupts
            alternative splicing and causes cardiomyopathy
  JOURNAL   Mol Cell Biol 25 (14), 6267-6278 (2005)
   PUBMED   15988035
  REMARK    GeneRIF: CELF protein activity is required for normal alternative
            splicing in the heart in vivo and normal CELF-mediated alternative
            splicing regulation is in turn required for normal cardiac
            function.
REFERENCE   7  (residues 1 to 476)
  AUTHORS   Meins M, Schlickum S, Wilhelm C, Missbach J, Yadav S, Glaser B,
            Grzmil M, Burfeind P and Laccone F.
  TITLE     Identification and characterization of murine Brunol4, a new member
            of the elav/bruno family
  JOURNAL   Cytogenet Genome Res 97 (3-4), 254-260 (2002)
   PUBMED   12438720
  REMARK    GeneRIF: cloning and characterization
REFERENCE   8  (residues 1 to 476)
  AUTHORS   Ladd AN, Charlet N and Cooper TA.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   9  (residues 1 to 476)
  AUTHORS   Good PJ, Chen Q, Warner SJ and Herring DC.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
REFERENCE   10 (residues 1 to 476)
  AUTHORS   Yulug IG, Egan SE, See CG and Fisher EM.
  TITLE     Mapping GRB2, a signal transduction gene in the human and the mouse
  JOURNAL   Genomics 22 (2), 313-318 (1994)
   PUBMED   7806216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121094.8 and AC144938.3.
            
            On Apr 12, 2018 this sequence version replaced XP_017173286.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.179136.1,
                                           SRR1660813.266419.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..476
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 13.92 cM"
     Protein         1..476
                     /product="CUGBP Elav-like family member 4 isoform 43"
                     /note="CUG-BP- and ETR-3-like factor 4; bruno-like protein
                     4; RNA-binding protein BRUNOL-4; bruno-like 4, RNA binding
                     protein"
                     /calculated_mol_wt=50789
     Region          49..135
                     /region_name="RRM1_CELF3_4_5_6"
                     /note="RNA recognition motif 1 (RRM1) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12632"
                     /db_xref="CDD:410041"
     Site            order(55,57,59..60,63,82,84,86,95..97,99,129,131)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410041"
     Region          141..221
                     /region_name="RRM2_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12635"
                     /db_xref="CDD:410043"
     Site            order(143,145,147..148,151,170,172,174,182..184,186,216,
                     218)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410043"
     Region          407..465
                     /region_name="RRM_SF"
                     /note="RNA recognition motif (RRM) superfamily; cl17169"
                     /db_xref="CDD:450164"
     CDS             1..476
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /coded_by="NM_001362325.1:531..1961"
                     /note="isoform 43 is encoded by transcript variant 45"
                     /db_xref="GeneID:108013"
                     /db_xref="MGI:MGI:1932407"
ORIGIN      
        1 myikmatlan gqadnaslst nglgsspgsa ghmnglshsp gnpstipmkd hdaiklfigq
       61 iprnldekdl kplfeefgki yeltvlkdrf tgmhkgcafl tyceresalk aqsalheqkt
      121 lpgmnrpiqv kpadsesrge drklfvgmln kqqseddvrr lfeafgniee ctilrgpdgn
      181 skgcafvkys shaeaqaain alhgsqtmpg assslvvkfa dtdkertmrr mqqmagqmgm
      241 fnpmaipfga ygayaqalmq qqaalmasva qggylnpmaa faaaqmqqma alnmnglaaa
      301 pmtptsggst ppgitapavp sipspigvng ftglppqang qpaaeavfan gihpypaqsp
      361 taadplqqay agvqqyagpa aypaaygqis qafpqpppmi pqqqregpeg cnlliyhlpq
      421 efgdaelmqm flpfgfvsfd npasaqtaiq amngfqigmk rlkvqlkrpk danrpy
//
LOCUS       NP_001394528             384 aa            linear   ROD 09-OCT-2023
DEFINITION  mitogen-activated protein kinase 10 isoform 12 [Mus musculus].
ACCESSION   NP_001394528 XP_030110379
VERSION     NP_001394528.1
DBSOURCE    REFSEQ: accession NM_001407599.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 384)
  AUTHORS   Priego M, Noriega L, Kalinin S, Hoffman LM, Feinstein DL and
            Morfini G.
  TITLE     Genetic deletion of c-Jun amino-terminal kinase 3 (JNK3) modestly
            increases disease severity in a mouse model of multiple sclerosis
  JOURNAL   J Neuroimmunol 382, 578152 (2023)
   PUBMED   37454525
  REMARK    GeneRIF: Genetic deletion of c-Jun amino-terminal kinase 3 (JNK3)
            modestly increases disease severity in a mouse model of multiple
            sclerosis.
REFERENCE   2  (residues 1 to 384)
  AUTHORS   Liu F, Deng Y, Zhao Y, Li Z, Gao J, Zhang Y, Yang X, Liu Y and Xia
            Y.
  TITLE     Time series RNA-seq analysis identifies MAPK10 as a critical gene
            in diabetes mellitus-induced atrial fibrillation in mice
  JOURNAL   J Mol Cell Cardiol 168, 70-82 (2022)
   PUBMED   35489387
  REMARK    GeneRIF: Time series RNA-seq analysis identifies MAPK10 as a
            critical gene in diabetes mellitus-induced atrial fibrillation in
            mice.
REFERENCE   3  (residues 1 to 384)
  AUTHORS   Cunningham JG, Scripter JD, Nti SA and Tucker ES.
  TITLE     Early construction of the thalamocortical axon pathway requires
            c-Jun N-terminal kinase signaling within the ventral forebrain
  JOURNAL   Dev Dyn 251 (3), 459-480 (2022)
   PUBMED   34494344
REFERENCE   4  (residues 1 to 384)
  AUTHORS   Goodwani S, Fernandez C, Acton PJ, Buggia-Prevot V, McReynolds ML,
            Ma J, Hu CH, Hamby ME, Jiang Y, Le K, Soth MJ, Jones P and Ray WJ.
  TITLE     Dual Leucine Zipper Kinase Is Constitutively Active in the Adult
            Mouse Brain and Has Both Stress-Induced and Homeostatic Functions
  JOURNAL   Int J Mol Sci 21 (14), 4849 (2020)
   PUBMED   32659913
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 384)
  AUTHORS   Loughran G, Chou MY, Ivanov IP, Jungreis I, Kellis M, Kiran AM,
            Baranov PV and Atkins JF.
  TITLE     Evidence of efficient stop codon readthrough in four mammalian
            genes
  JOURNAL   Nucleic Acids Res 42 (14), 8928-8938 (2014)
   PUBMED   25013167
REFERENCE   6  (residues 1 to 384)
  AUTHORS   Beier H and Grimm M.
  TITLE     Misreading of termination codons in eukaryotes by natural nonsense
            suppressor tRNAs
  JOURNAL   Nucleic Acids Res 29 (23), 4767-4782 (2001)
   PUBMED   11726686
  REMARK    Review article
REFERENCE   7  (residues 1 to 384)
  AUTHORS   Yang DD, Kuan CY, Whitmarsh AJ, Rincon M, Zheng TS, Davis RJ, Rakic
            P and Flavell RA.
  TITLE     Absence of excitotoxicity-induced apoptosis in the hippocampus of
            mice lacking the Jnk3 gene
  JOURNAL   Nature 389 (6653), 865-870 (1997)
   PUBMED   9349820
REFERENCE   8  (residues 1 to 384)
  AUTHORS   Casanova E, Garate C, Ovalle S, Calvo P and Chinchetru MA.
  TITLE     Identification of four splice variants of the mouse
            stress-activated protein kinase JNK/SAPK alpha-isoform
  JOURNAL   Neuroreport 7 (7), 1320-1324 (1996)
   PUBMED   8817558
REFERENCE   9  (residues 1 to 384)
  AUTHORS   Martin JH, Mohit AA and Miller CA.
  TITLE     Developmental expression in the mouse nervous system of the p493F12
            SAP kinase
  JOURNAL   Brain Res Mol Brain Res 35 (1-2), 47-57 (1996)
   PUBMED   8717339
REFERENCE   10 (residues 1 to 384)
  AUTHORS   Suzuki J, Yoshida S, Chen ZL, Momota Y, Kato K, Hirata A and
            Shiosaka S.
  TITLE     Ontogeny of neuropsin mRNA expression in the mouse brain
  JOURNAL   Neurosci Res 23 (4), 345-351 (1995)
   PUBMED   8602273
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC160244.11, AC123664.15,
            AC137121.9 and AC125252.7.
            
            On Jun 6, 2022 this sequence version replaced XP_030110379.1.
            
            Summary: The protein encoded by this gene is a member of the MAP
            kinase family. MAP kinases act as integration points for multiple
            biochemical signals, and thus are involved in a wide variety of
            cellular processes, such as proliferation, differentiation,
            transcription regulation and development. This kinase is
            specifically expressed in a subset of neurons in the nervous system
            and is activated by threonine and tyrosine phosphorylation.
            Targeted deletion of this gene in mice suggests that it may have a
            role in stress-induced neuronal apoptosis. Alternatively spliced
            transcript variants encoding different isoforms have been found for
            this gene. A recent study provided evidence for translational
            readthrough in this gene, and expression of an additional
            C-terminally extended isoform via the use of an alternative
            in-frame translation termination codon. [provided by RefSeq, Dec
            2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.3294689.1,
                                           SRR17784646.337333.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849376 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..384
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 49.61 cM"
     Protein         1..384
                     /product="mitogen-activated protein kinase 10 isoform 12"
                     /EC_number="2.7.11.24"
                     /note="JNK3 beta1 protein kinase; JNK3 beta2 protein
                     kinase; MAP kinase 10; MAP kinase p49 3F12; c-Jun
                     N-terminal kinase 3; stress-activated protein kinase JNK3;
                     SAPK/Erk/kinase 2"
                     /calculated_mol_wt=43736
     Region          25..360
                     /region_name="STKc_JNK"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     c-Jun N-terminal Kinase; cd07850"
                     /db_xref="CDD:270840"
     Site            order(32..38,40,53,55,72,86,108..114,116..117,151,153,
                     155..156,158,168..169,172,183,185..188,190,227)
                     /site_type="active"
                     /db_xref="CDD:270840"
     Site            order(32..38,40,53,55,86,108..114,158,168)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270840"
     Site            order(72,116,151,153,172,183,185..188,190,227)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270840"
     Site            order(112,118,127,130,159..163,323..324,326,329)
                     /site_type="other"
                     /note="KIM docking site [polypeptide binding]"
                     /db_xref="CDD:270840"
     Site            order(168..178,182..190)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270840"
     CDS             1..384
                     /gene="Mapk10"
                     /gene_synonym="C230008H04Rik; JNK3; JNK3B1; JNK3B2;
                     p493F12; p54bSAPK; SAPK(beta); Serk2"
                     /coded_by="NM_001407599.1:658..1812"
                     /note="isoform 12 is encoded by transcript variant 22"
                     /db_xref="GeneID:26414"
                     /db_xref="MGI:MGI:1346863"
ORIGIN      
        1 mskskvdnqf ysvevgdstf tvlkryqnlk pigsgaqgiv caaydavldr nvaikklsrp
       61 fqnqthakra yrelvlmkcv nhkniislln vftpqktlee fqdvylvmel mdanlcqviq
      121 meldhermsy llyqmlcgik hlhsagiihr dlkpsnivvk sdctlkildf glartagtsf
      181 mmtpyvvtry yrapevilgm gykenvdlws vgcimgemvk gtvlfpgtdh idqwnkvieq
      241 lgtpcpefmk klqptvrnyv enrpkyaglt fpklfpdslf padsehnklk asqardllsk
      301 mlvidpakri svddalqhpy invwydpaev eapppqiydk qlderehtie ewkeliykev
      361 mnseektkng vvkgqpspsa qvqq
//
LOCUS       NP_035621                296 aa            linear   ROD 09-OCT-2023
DEFINITION  stanniocalcin-2 precursor [Mus musculus].
ACCESSION   NP_035621
VERSION     NP_035621.1
DBSOURCE    REFSEQ: accession NM_011491.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 296)
  AUTHORS   Patil NY, Rus I and Joshi AD.
  TITLE     Role of ERK1/2 Signaling in Cinnabarinic Acid-Driven Stanniocalcin
            2-Mediated Protection against Alcohol-Induced Apoptosis
  JOURNAL   J Pharmacol Exp Ther 387 (1), 111-120 (2023)
   PUBMED   37562971
  REMARK    GeneRIF: Role of ERK1/2 Signaling in Cinnabarinic Acid-Driven
            Stanniocalcin 2-Mediated Protection against Alcohol-Induced
            Apoptosis.
REFERENCE   2  (residues 1 to 296)
  AUTHORS   Lionikas A, Hernandez Cordero AI, Kilikevicius A, Carroll AM,
            Bewick GS, Bunger L, Ratkevicius A, Heisler LK, Harboe M and Oxvig
            C.
  TITLE     Stanniocalcin-2 inhibits skeletal muscle growth and is upregulated
            in functional overload-induced hypertrophy
  JOURNAL   Physiol Rep 11 (15), e15793 (2023)
   PUBMED   37568262
  REMARK    GeneRIF: Stanniocalcin-2 inhibits skeletal muscle growth and is
            upregulated in functional overload-induced hypertrophy.
REFERENCE   3  (residues 1 to 296)
  AUTHORS   Zhang L, He X, Xiong Y, Ran Q, Xiong A, Wang J, Wu D, Niu B and Li
            G.
  TITLE     Transcriptome-wide profiling discover: PM2.5 aggravates airway
            dysfunction through epithelial barrier damage regulated by
            Stanniocalcin 2 in an OVA-induced model
  JOURNAL   Ecotoxicol Environ Saf 220, 112408 (2021)
   PUBMED   34111662
  REMARK    GeneRIF: Transcriptome-wide profiling discover: PM2.5 aggravates
            airway dysfunction through epithelial barrier damage regulated by
            Stanniocalcin 2 in an OVA-induced model.
REFERENCE   4  (residues 1 to 296)
  AUTHORS   Jeon Y, Shin JE, Kwon M, Cho E, Cavalli V and Cho Y.
  TITLE     In Vivo Gene Delivery of STC2 Promotes Axon Regeneration in Sciatic
            Nerves
  JOURNAL   Mol Neurobiol 58 (2), 750-760 (2021)
   PUBMED   33011858
  REMARK    GeneRIF: In Vivo Gene Delivery of STC2 Promotes Axon Regeneration
            in Sciatic Nerves.
REFERENCE   5  (residues 1 to 296)
  AUTHORS   Hernandez Cordero AI, Gonzales NM, Parker CC, Sokolof G,
            Vandenbergh DJ, Cheng R, Abney M, Sko A, Douglas A, Palmer AA,
            Gregory JS and Lionikas A.
  TITLE     Genome-wide Associations Reveal Human-Mouse Genetic Convergence and
            Modifiers of Myogenesis, CPNE1 and STC2
  JOURNAL   Am J Hum Genet 105 (6), 1222-1236 (2019)
   PUBMED   31761296
  REMARK    Erratum:[Am J Hum Genet. 2020 Jan 2;106(1):138. PMID: 31901248]
REFERENCE   6  (residues 1 to 296)
  AUTHORS   Ito D, Walker JR, Thompson CS, Moroz I, Lin W, Veselits ML, Hakim
            AM, Fienberg AA and Thinakaran G.
  TITLE     Characterization of stanniocalcin 2, a novel target of the
            mammalian unfolded protein response with cytoprotective properties
  JOURNAL   Mol Cell Biol 24 (21), 9456-9469 (2004)
   PUBMED   15485913
  REMARK    GeneRIF: induced STC2 expression is an essential feature of
            survival component of the unfolded-protein response
REFERENCE   7  (residues 1 to 296)
  AUTHORS   Yadav N, Lee J, Kim J, Shen J, Hu MC, Aldaz CM and Bedford MT.
  TITLE     Specific protein methylation defects and gene expression
            perturbations in coactivator-associated arginine methyltransferase
            1-deficient mice
  JOURNAL   Proc Natl Acad Sci U S A 100 (11), 6464-6468 (2003)
   PUBMED   12756295
REFERENCE   8  (residues 1 to 296)
  AUTHORS   Moore EE, Kuestner RE, Conklin DC, Whitmore TE, Downey W, Buddle
            MM, Adams RL, Bell LA, Thompson DL, Wolf A, Chen L, Stamm MR, Grant
            FJ, Lok S, Ren H and De Jongh KS.
  TITLE     Stanniocalcin 2: characterization of the protein and its
            localization to human pancreatic alpha cells
  JOURNAL   Horm Metab Res 31 (7), 406-414 (1999)
   PUBMED   10450831
REFERENCE   9  (residues 1 to 296)
  AUTHORS   Ishibashi K, Miyamoto K, Taketani Y, Morita K, Takeda E, Sasaki S
            and Imai M.
  TITLE     Molecular cloning of a second human stanniocalcin homologue (STC2)
  JOURNAL   Biochem Biophys Res Commun 250 (2), 252-258 (1998)
   PUBMED   9753616
REFERENCE   10 (residues 1 to 296)
  AUTHORS   Chang AC and Reddel RR.
  TITLE     Identification of a second stanniocalcin cDNA in mouse and human:
            stanniocalcin 2
  JOURNAL   Mol Cell Endocrinol 141 (1-2), 95-99 (1998)
   PUBMED   9723890
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF031035.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF031035.1, BC012206.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..296
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 18.4 cM"
     Protein         1..296
                     /product="stanniocalcin-2 precursor"
                     /calculated_mol_wt=30068
     sig_peptide     1..24
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=2552
     Region          12..213
                     /region_name="Stanniocalcin"
                     /note="Stanniocalcin family; pfam03298"
                     /db_xref="CDD:397405"
     Region          21..44
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O88452.1)"
     Site            73
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O88452.1)"
     Region          218..296
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O88452.1)"
     CDS             1..296
                     /gene="Stc2"
                     /gene_synonym="mustc2; Stc-2; Stc2l"
                     /coded_by="NM_011491.3:200..1090"
                     /db_xref="CCDS:CCDS24512.1"
                     /db_xref="GeneID:20856"
                     /db_xref="MGI:MGI:1316731"
ORIGIN      
        1 mcaerlgqfv tlalvfatld paqgtdstnp pegpqdrssq qkgrlslqnt aeiqhclvna
       61 gdvgcgvfec fennsceiqg lhgicmtflh nagkfdaqgk sfikdalrck ahalrhkfgc
      121 isrkcpaire mvfqlqrecy lkhdlcsaaq envgvivemi hfkdlllhep yvdlvnlllt
      181 cgedvkeavt rsvqaqceqs wgglcsilsf ctsniqrppt aapehqplad raqlsrphhr
      241 dtdhhltanr gakgergsks hpnahargrt ggqsaqgpsg ssewedeqse ysdirr
//
LOCUS       NP_001344567             764 aa            linear   ROD 09-OCT-2023
DEFINITION  DNA-binding protein SATB1 isoform 1 [Mus musculus].
ACCESSION   NP_001344567 XP_017172853
VERSION     NP_001344567.1
DBSOURCE    REFSEQ: accession NM_001357638.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 764)
  AUTHORS   Naito T, Ise M, Tanaka Y, Kohwi-Shigematsu T and Kondo M.
  TITLE     Crucial Roles of SATB1 in Regulation of Thymocyte Migration after
            Positive Selection
  JOURNAL   J Immunol 211 (2), 209-218 (2023)
   PUBMED   37256264
  REMARK    GeneRIF: Crucial Roles of SATB1 in Regulation of Thymocyte
            Migration after Positive Selection.
REFERENCE   2  (residues 1 to 764)
  AUTHORS   Nomura A, Kobayashi T, Seo W, Ohno-Oishi M, Kakugawa K, Muroi S,
            Yoshida H, Endo TA, Moro K and Taniuchi I.
  TITLE     Identification of a novel enhancer essential for Satb1 expression
            in TH2 cells and activated ILC2s
  JOURNAL   Life Sci Alliance 6 (8), e202301897 (2023)
   PUBMED   37193606
  REMARK    GeneRIF: Identification of a novel enhancer essential for Satb1
            expression in TH2 cells and activated ILC2s.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 764)
  AUTHORS   Knowles SJ, Stafford AM, Zaman T, Angara K, Williams MR, Newbern JM
            and Vogt D.
  TITLE     Distinct hyperactive RAS/MAPK alleles converge on common GABAergic
            interneuron core programs
  JOURNAL   Development 150 (10) (2023)
   PUBMED   37254876
REFERENCE   4  (residues 1 to 764)
  AUTHORS   Wang B, Ji L and Bian Q.
  TITLE     SATB1 regulates 3D genome architecture in T cells by constraining
            chromatin interactions surrounding CTCF-binding sites
  JOURNAL   Cell Rep 42 (4), 112323 (2023)
   PUBMED   37000624
  REMARK    GeneRIF: SATB1 regulates 3D genome architecture in T cells by
            constraining chromatin interactions surrounding CTCF-binding sites.
REFERENCE   5  (residues 1 to 764)
  AUTHORS   Vasilopoulos N, Kaplanian A, Vinos M, Katsaiti Y, Christodoulou O,
            Denaxa M and Skaliora I.
  TITLE     The role of selective SATB1 deletion in somatostatin expressing
            interneurons on endogenous network activity and the transition to
            epilepsy
  JOURNAL   J Neurosci Res 101 (4), 424-447 (2023)
   PUBMED   36541427
  REMARK    GeneRIF: The role of selective SATB1 deletion in somatostatin
            expressing interneurons on endogenous network activity and the
            transition to epilepsy.
REFERENCE   6  (residues 1 to 764)
  AUTHORS   Seo J, Lozano MM and Dudley JP.
  TITLE     Nuclear matrix binding regulates SATB1-mediated transcriptional
            repression
  JOURNAL   J Biol Chem 280 (26), 24600-24609 (2005)
   PUBMED   15851481
  REMARK    GeneRIF: SATB1-mediated transcriptional repression is regulated by
            nuclear matrix binding
REFERENCE   7  (residues 1 to 764)
  AUTHORS   Nie H, Maika SD, Tucker PW and Gottlieb PD.
  TITLE     A role for SATB1, a nuclear matrix association region-binding
            protein, in the development of CD8SP thymocytes and peripheral T
            lymphocytes
  JOURNAL   J Immunol 174 (8), 4745-4752 (2005)
   PUBMED   15814699
  REMARK    GeneRIF: essential role for SATB1 late in the development and
            maturation of CD8SP T cells
REFERENCE   8  (residues 1 to 764)
  AUTHORS   Cai S, Han HJ and Kohwi-Shigematsu T.
  TITLE     Tissue-specific nuclear architecture and gene expression regulated
            by SATB1
  JOURNAL   Nat Genet 34 (1), 42-51 (2003)
   PUBMED   12692553
  REMARK    GeneRIF: in thymocyte nuclei, SATB1 has a cage-like 'network'
            distribution circumscribing heterochromatin and selectively tethers
            specialized DNA sequences onto its network
REFERENCE   9  (residues 1 to 764)
  AUTHORS   Alvarez JD, Yasui DH, Niida H, Joh T, Loh DY and Kohwi-Shigematsu
            T.
  TITLE     The MAR-binding protein SATB1 orchestrates temporal and spatial
            expression of multiple genes during T-cell development
  JOURNAL   Genes Dev 14 (5), 521-535 (2000)
   PUBMED   10716941
REFERENCE   10 (residues 1 to 764)
  AUTHORS   Nakagomi K, Kohwi Y, Dickinson LA and Kohwi-Shigematsu T.
  TITLE     A novel DNA-binding motif in the nuclear matrix attachment
            DNA-binding protein SATB1
  JOURNAL   Mol Cell Biol 14 (3), 1852-1860 (1994)
   PUBMED   8114718
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154796.2, AC131975.28 and AW045567.1.
            
            On Nov 4, 2017 this sequence version replaced XP_017172853.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.176553.1,
                                           SRR7974084.10601.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..764
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 26.81 cM"
     Protein         1..764
                     /product="DNA-binding protein SATB1 isoform 1"
                     /note="DNA-binding protein Satb1"
                     /calculated_mol_wt=85749
     Region          1..56
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60611.2)"
     Region          20..40
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60611.2)"
     Region          72..170
                     /region_name="ULD"
                     /note="Ubiquitin-like oligomerization domain of SATB;
                     pfam16534"
                     /db_xref="CDD:435405"
     Site            order(75,77,94..98,100,132,134,137..138,144..147,155..156,
                     159..161,163..164)
                     /site_type="other"
                     /note="tetramer interface [polypeptide binding]"
                     /db_xref="CDD:211426"
     Site            136
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q01826; propagated from
                     UniProtKB/Swiss-Prot (Q60611.2)"
     Region          139..143
                     /region_name="Protein interaction. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60611.2)"
     Region          176..247
                     /region_name="CUTL"
                     /note="CUT1-like DNA-binding domain of SATB; pfam16557"
                     /db_xref="CDD:435427"
     Site            185
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q01826; propagated from
                     UniProtKB/Swiss-Prot (Q60611.2)"
     Region          224..278
                     /region_name="Nuclear matrix targeting sequence (NMTS)"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60611.2)"
     Region          224..278
                     /region_name="Nuclear matrix targeting sequence (NMTS).
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60611.2)"
     Site            254..255
                     /site_type="cleavage"
                     /note="Cleavage, by caspases; propagated from
                     UniProtKB/Swiss-Prot (Q60611.2)"
     Region          266..307
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60611.2)"
     Region          372..444
                     /region_name="CUT"
                     /note="CUT domain; pfam02376"
                     /db_xref="CDD:426745"
     Region          450..474
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60611.2)"
     Region          497..567
                     /region_name="CUT"
                     /note="CUT domain; pfam02376"
                     /db_xref="CDD:426745"
     Region          591..650
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60611.2)"
     Site            638
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q60611.2)"
     Region          645..702
                     /region_name="HOX"
                     /note="Homeodomain; smart00389"
                     /db_xref="CDD:197696"
     Site            order(647..650,652,670,676,689,691..692,695..696,698..700,
                     702..703)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     Site            order(648,651,692,695..696,699)
                     /site_type="other"
                     /note="specific DNA base contacts [nucleotide binding]"
                     /db_xref="CDD:238039"
     CDS             1..764
                     /gene="Satb1"
                     /gene_synonym="2610306G12Rik"
                     /coded_by="NM_001357638.1:463..2757"
                     /note="isoform 1 is encoded by transcript variant 5"
                     /db_xref="CCDS:CCDS28876.1"
                     /db_xref="GeneID:20230"
                     /db_xref="MGI:MGI:105084"
ORIGIN      
        1 mdhlneatqg kehsemsnnv sdpkgppaki arleqngspl grgrlgstgg kmqgvplkhs
       61 ghlmktnlrk gtmlpvfcvv ehyenaieyd ckeehaefvl vrkdmlfnql iemallslgy
      121 shssaaqakg liqvgkwnpv plsyvtdapd atvadmlqdv yhvvtlkiql hscpkledlp
      181 peqwshttvr nalkdllkdm nqsslakecp lsqsmissiv nstyyanvsa akcqefgrwy
      241 khfkktkdmm vemdslsels qqganhvnfg qqpvpgntae qppspaqlsh gsqpsvrtpl
      301 pnlhpglvst pispqlvnqq lvmaqllnqq yavnrllaqq slnqqylnhp ppvsrsmnkp
      361 leqqvstnte vsseiyqwvr delkragisq avfarvafnr tqgllseilr keedpktasq
      421 sllvnlramq nflqlpeaer driyqderer slnaasamgp apllstppsr ppqvktatla
      481 terngkpenn tmninasiyd eiqqemkrak vsqalfakva atksqgwlce llrwkedpsp
      541 enrtlwenls mirrflslpq perdaiyeqe snavhhhgdr pphiihvpae qiqqqqqqqq
      601 qqqqqqqppp pppqpqpqpq agprlpprqp tvassaesde enrqktrprt kisvealgil
      661 qsfiqdvgly pdeeaiqtls aqldlpkyti ikffqnqryy lkhhgklkdn sglevdvaey
      721 kdeellkdle esvqdknant lfsvkleeel svegstdvna dlkd
//
LOCUS       NP_001392986             140 aa            linear   ROD 09-OCT-2023
DEFINITION  bcl-2-like protein 11 isoform 2 [Mus musculus].
ACCESSION   NP_001392986
VERSION     NP_001392986.1
DBSOURCE    REFSEQ: accession NM_001406057.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 140)
  AUTHORS   Jiang M, Wang XB and Jiang S.
  TITLE     circ_0000018 downregulation peripherally ameliorates
            neuroprotection against acute ischemic stroke through the
            miR-871/BCL2L11 axis
  JOURNAL   Mol Med Rep 28 (5) (2023)
   PUBMED   37772397
  REMARK    GeneRIF: circ_0000018 downregulation peripherally ameliorates
            neuroprotection against acute ischemic stroke through the
            miR-871/BCL2L11 axis.
REFERENCE   2  (residues 1 to 140)
  AUTHORS   Lu Y, Tang K, Wang S, Tian Z, Fan Y, Li B, Wang M, Zhao J and Xie
            J.
  TITLE     Dach1 deficiency drives alveolar epithelium apoptosis in pulmonary
            fibrosis via modulating C-Jun/Bim activity
  JOURNAL   Transl Res 257, 54-65 (2023)
   PUBMED   36754276
  REMARK    GeneRIF: Dach1 deficiency drives alveolar epithelium apoptosis in
            pulmonary fibrosis via modulating C-Jun/Bim activity.
REFERENCE   3  (residues 1 to 140)
  AUTHORS   Nguyen HV, Vandenberg CJ, Robati MR, Ng AP and Cory S.
  TITLE     MNT suppresses T cell apoptosis via BIM and is critical for T
            lymphomagenesis
  JOURNAL   Cell Death Differ 30 (4), 1018-1032 (2023)
   PUBMED   36755068
  REMARK    GeneRIF: MNT suppresses T cell apoptosis via BIM and is critical
            for T lymphomagenesis.
REFERENCE   4  (residues 1 to 140)
  AUTHORS   Chen H, Bai Y, Kobayashi M, Xiao S, Cai W, Barajas S, Chen S, Miao
            J, Meke FN, Vemula S, Ropa JP, Croop JM, Boswell HS, Wan J, Jia Y,
            Liu H, Li LS, Altman JK, Eklund EA, Ji P, Tong W, Band H, Huang DT,
            Platanias LC, Zhang ZY and Liu Y.
  TITLE     PRL2 phosphatase enhances oncogenic FLT3 signaling via
            dephosphorylation of the E3 ubiquitin ligase CBL at tyrosine 371
  JOURNAL   Blood 141 (3), 244-259 (2023)
   PUBMED   36206490
REFERENCE   5  (residues 1 to 140)
  AUTHORS   Brahma MK, Xiao P, Popa M, Negueruela J, Vandenbempt V, Demine S,
            Cardozo AK and Gurzov EN.
  TITLE     Nova1 or Bim Deficiency in Pancreatic beta-Cells Does Not Alter
            Multiple Low-Dose Streptozotocin-Induced Diabetes and Diet-Induced
            Obesity in Mice
  JOURNAL   Nutrients 14 (18), 3866 (2022)
   PUBMED   36145242
  REMARK    GeneRIF: Nova1 or Bim Deficiency in Pancreatic beta-Cells Does Not
            Alter Multiple Low-Dose Streptozotocin-Induced Diabetes and
            Diet-Induced Obesity in Mice.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 140)
  AUTHORS   Bouillet P, Zhang LC, Huang DC, Webb GC, Bottema CD, Shore P, Eyre
            HJ, Sutherland GR and Adams JM.
  TITLE     Gene structure alternative splicing, and chromosomal localization
            of pro-apoptotic Bcl-2 relative Bim
  JOURNAL   Mamm Genome 12 (2), 163-168 (2001)
   PUBMED   11210187
REFERENCE   7  (residues 1 to 140)
  AUTHORS   Bouillet P, Metcalf D, Huang DC, Tarlinton DM, Kay TW, Kontgen F,
            Adams JM and Strasser A.
  TITLE     Proapoptotic Bcl-2 relative Bim required for certain apoptotic
            responses, leukocyte homeostasis, and to preclude autoimmunity
  JOURNAL   Science 286 (5445), 1735-1738 (1999)
   PUBMED   10576740
REFERENCE   8  (residues 1 to 140)
  AUTHORS   Puthalakath H, Huang DC, O'Reilly LA, King SM and Strasser A.
  TITLE     The proapoptotic activity of the Bcl-2 family member Bim is
            regulated by interaction with the dynein motor complex
  JOURNAL   Mol Cell 3 (3), 287-296 (1999)
   PUBMED   10198631
REFERENCE   9  (residues 1 to 140)
  AUTHORS   Reed JC.
  TITLE     Bcl-2 family proteins
  JOURNAL   Oncogene 17 (25), 3225-3236 (1998)
   PUBMED   9916985
  REMARK    Review article
REFERENCE   10 (residues 1 to 140)
  AUTHORS   O'Connor L, Strasser A, O'Reilly LA, Hausmann G, Adams JM, Cory S
            and Huang DC.
  TITLE     Bim: a novel member of the Bcl-2 family that promotes apoptosis
  JOURNAL   EMBO J 17 (2), 384-395 (1998)
   PUBMED   9430630
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL805950.11.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253013.859364.1,
                                           SRR13422600.1774686.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..140
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 62.23 cM"
     Protein         1..140
                     /product="bcl-2-like protein 11 isoform 2"
                     /note="bcl-2-like protein 11; bcl2-interacting mediator of
                     cell death; Bcl2 interacting mediator of cell death;
                     BCL2-like 11 (apoptosis facilitator)"
                     /calculated_mol_wt=16074
     Region          4..40
                     /region_name="Bim_N"
                     /note="Bim protein N-terminus; pfam06773"
                     /db_xref="CDD:429111"
     Region          73..108
                     /region_name="Bclx_interact"
                     /note="Bcl-x interacting, BH3 domain; pfam08945"
                     /db_xref="CDD:430337"
     CDS             1..140
                     /gene="Bcl2l11"
                     /gene_synonym="1500006F24Rik; bcl2-L-11; Bim; Bod"
                     /coded_by="NM_001406057.1:221..643"
                     /note="isoform 2 is encoded by transcript variant 6"
                     /db_xref="GeneID:12125"
                     /db_xref="MGI:MGI:1197519"
ORIGIN      
        1 makqpsdvss ecdreggqlq paerppqlrp gaptslqtep qdrspapmsc dkstqtpspp
       61 cqafnhylsa masirqsqee pedlrpeiri aqelrrigde fnetytrrvf andyreaedh
      121 pqmvilqllr fifrlvwrrh
//
LOCUS       NP_067249                 98 aa            linear   ROD 09-OCT-2023
DEFINITION  C-X-C motif chemokine 10 precursor [Mus musculus].
ACCESSION   NP_067249 XP_911349 XP_924823 XP_924830
VERSION     NP_067249.1
DBSOURCE    REFSEQ: accession NM_021274.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 98)
  AUTHORS   Wang J, Peng Z, Guo J, Wang Y, Wang S, Jiang H, Wang M, Xie Y, Li
            X, Hu M, Xie Y, Cheng H, Li T, Jia L, Song J, Wang Y, Hou J and Liu
            Z.
  TITLE     CXCL10 Recruitment of gammadelta T Cells into the Hypoxic Bone
            Marrow Environment Leads to IL17 Expression and Multiple Myeloma
            Progression
  JOURNAL   Cancer Immunol Res 11 (10), 1384-1399 (2023)
   PUBMED   37586075
  REMARK    GeneRIF: CXCL10 Recruitment of gammadelta T Cells into the Hypoxic
            Bone Marrow Environment Leads to IL17 Expression and Multiple
            Myeloma Progression.
REFERENCE   2  (residues 1 to 98)
  AUTHORS   Zhou C, Shen Z, Shen B, Dai W, Sun Z, Guo Y, Xu X, Wang J, Lu J,
            Zhang Q, Luo X, Qu Y, Dong H and Lu L.
  TITLE     FABP4 in LSECs promotes CXCL10-mediated macrophage recruitment and
            M1 polarization during NAFLD progression
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1869 (7), 166810 (2023)
   PUBMED   37487374
  REMARK    GeneRIF: FABP4 in LSECs promotes CXCL10-mediated macrophage
            recruitment and M1 polarization during NAFLD progression.
REFERENCE   3  (residues 1 to 98)
  AUTHORS   Qiao XY, Wang Y, Zhang W, Li Q, Liu C, Dao JJ, Qiao CM, Cui C, Shen
            YQ and Zhao WJ.
  TITLE     Involvement of CXCL10 in Neuronal Damage under the Condition of
            Spinal Cord Injury and the Potential Therapeutic Effect of Nrg1
  JOURNAL   J Integr Neurosci 22 (4), 96 (2023)
   PUBMED   37519170
  REMARK    GeneRIF: Involvement of CXCL10 in Neuronal Damage under the
            Condition of Spinal Cord Injury and the Potential Therapeutic
            Effect of Nrg1.
REFERENCE   4  (residues 1 to 98)
  AUTHORS   Shi ZB, Hu Y, Ruan QQ, Fan M, Zhao M and Zhu LL.
  TITLE     [Hypoxia promotes lipopolysaccharide-induced CXCL10 expression in
            microglia]
  JOURNAL   Sheng Li Xue Bao 75 (2), 153-159 (2023)
   PUBMED   37089089
  REMARK    GeneRIF: [Hypoxia promotes lipopolysaccharide-induced CXCL10
            expression in microglia].
REFERENCE   5  (residues 1 to 98)
  AUTHORS   Coburn PS, Parrott AC, Miller FC, LaGrow AL, Mursalin MH and
            Callegan MC.
  TITLE     The Role of C-X-C Chemokines in Staphylococcus aureus
            Endophthalmitis
  JOURNAL   Invest Ophthalmol Vis Sci 64 (3), 10 (2023)
   PUBMED   36867134
REFERENCE   6  (residues 1 to 98)
  AUTHORS   Smith JB and Herschman HR.
  TITLE     Glucocorticoid-attenuated response genes encode intercellular
            mediators, including a new C-X-C chemokine
  JOURNAL   J Biol Chem 270 (28), 16756-16765 (1995)
   PUBMED   7622488
REFERENCE   7  (residues 1 to 98)
  AUTHORS   Gattass CR, King LB, Luster AD and Ashwell JD.
  TITLE     Constitutive expression of interferon gamma-inducible protein 10 in
            lymphoid organs and inducible expression in T cells and thymocytes
  JOURNAL   J Exp Med 179 (4), 1373-1378 (1994)
   PUBMED   8145049
REFERENCE   8  (residues 1 to 98)
  AUTHORS   Narumi S, Wyner LM, Stoler MH, Tannenbaum CS and Hamilton TA.
  TITLE     Tissue-specific expression of murine IP-10 mRNA following systemic
            treatment with interferon gamma
  JOURNAL   J Leukoc Biol 52 (1), 27-33 (1992)
   PUBMED   1640172
REFERENCE   9  (residues 1 to 98)
  AUTHORS   Vanguri P and Farber JM.
  TITLE     Identification of CRG-2. An interferon-inducible mRNA predicted to
            encode a murine monokine
  JOURNAL   J Biol Chem 265 (25), 15049-15057 (1990)
   PUBMED   2118520
REFERENCE   10 (residues 1 to 98)
  AUTHORS   Ohmori Y and Hamilton TA.
  TITLE     A macrophage LPS-inducible early gene encodes the murine homologue
            of IP-10
  JOURNAL   Biochem Biophys Res Commun 168 (3), 1261-1267 (1990)
   PUBMED   2189406
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY165450.1 and BC030067.1.
            
            On or before Dec 7, 2005 this sequence version replaced
            XP_924823.1, XP_924830.1, XP_911349.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030067.1, AK146144.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..98
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 46.57 cM"
     Protein         1..98
                     /product="C-X-C motif chemokine 10 precursor"
                     /note="C-X-C motif chemokine 10; gamma-IP10;
                     small-inducible cytokine B10; interferon-gamma induced
                     protein CRG-2; 10 kDa interferon gamma-induced protein;
                     small inducible cytokine B subfamily (Cys-X-Cys), member
                     10; chemokine (C-X-C motif) ligand 10; interferon
                     activated gene 10"
                     /calculated_mol_wt=8701
     sig_peptide     1..21
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=2106
     mat_peptide     22..98
                     /product="C-X-C motif chemokine 10. /id=PRO_0000005104"
                     /note="propagated from UniProtKB/Swiss-Prot (P17515.1)"
                     /calculated_mol_wt=8701
     Region          27..88
                     /region_name="Chemokine_CXC"
                     /note="1 of 4 subgroup designations based on the
                     arrangement of the two N-terminal cysteine residues;
                     includes a number of secreted growth factors and
                     interferons involved in mitogenic, chemotactic, and
                     inflammatory activity; many members contain an RCxC
                     motif...; cd00273"
                     /db_xref="CDD:238171"
     Site            order(27..29,35,40..45,54..56,66..67,71..73,79,84)
                     /site_type="active"
                     /note="receptor binding site [active]"
                     /db_xref="CDD:238171"
     Site            27..29
                     /site_type="active"
                     /note="ELR motif [active]"
                     /db_xref="CDD:238171"
     Site            order(28,31,45..46,49..51,61..64,66,71..72,75,82,86)
                     /site_type="other"
                     /note="tetramer interface [polypeptide binding]"
                     /db_xref="CDD:238171"
     Site            order(28,31,49,51,61,63,66,71..72)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:238171"
     Site            order(29..30,32)
                     /site_type="active"
                     /note="RCXC motif [active]"
                     /db_xref="CDD:238171"
     Site            order(31..37,40..45)
                     /site_type="active"
                     /note="N-loop [active]"
                     /db_xref="CDD:238171"
     Site            order(33..34,36,40,44,63,66,71,73)
                     /site_type="active"
                     /note="receptor binding cleft [active]"
                     /db_xref="CDD:238171"
     Site            order(41,43,78,81,83..86,88)
                     /site_type="other"
                     /note="glycosaminoglycan (GAG) binding site [chemical
                     binding]"
                     /db_xref="CDD:238171"
     Site            order(43,46,65,67,71..72)
                     /site_type="other"
                     /note="putative glycosaminoglycan (GAG) binding site
                     [chemical binding]"
                     /db_xref="CDD:238171"
     Site            order(45..46,50,62,64,75,82,86)
                     /site_type="other"
                     /note="dimer interface (I form) [polypeptide binding]"
                     /db_xref="CDD:238171"
     Site            54..56
                     /site_type="other"
                     /note="30s-loop"
                     /db_xref="CDD:238171"
     Site            54..56
                     /site_type="other"
                     /note="GPH motif"
                     /db_xref="CDD:238171"
     Site            67..69
                     /site_type="other"
                     /note="40s-loop"
                     /db_xref="CDD:238171"
     CDS             1..98
                     /gene="Cxcl10"
                     /gene_synonym="C7; CRG-2; gIP-10; Ifi10; INP10; IP-10;
                     IP10; mob-1; Scyb10"
                     /coded_by="NM_021274.2:76..372"
                     /db_xref="CCDS:CCDS39153.1"
                     /db_xref="GeneID:15945"
                     /db_xref="MGI:MGI:1352450"
ORIGIN      
        1 mnpsaavifc lillglsgtq giplartvrc ncihiddgpv rmraigklei ipaslscprv
       61 eiiatmkknd eqrclnpesk tiknlmkafs qkrskrap
//
LOCUS       NP_001409070             824 aa            linear   ROD 09-OCT-2023
DEFINITION  hypoxia-inducible factor 1-alpha isoform 4 [Mus musculus].
ACCESSION   NP_001409070 XP_036013089
VERSION     NP_001409070.1
DBSOURCE    REFSEQ: accession NM_001422141.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 824)
  AUTHORS   Xu R, Shen S, Wang D, Ye J, Song S, Wang Z and Yue Z.
  TITLE     The role of HIF-1alpha-mediated autophagy in ionizing
            radiation-induced testicular injury
  JOURNAL   J Mol Histol 54 (5), 439-451 (2023)
   PUBMED   37728670
  REMARK    GeneRIF: The role of HIF-1alpha-mediated autophagy in ionizing
            radiation-induced testicular injury.
REFERENCE   2  (residues 1 to 824)
  AUTHORS   Yang Z, Su W, Wei X, Qu S, Zhao D, Zhou J, Wang Y, Guan Q, Qin C,
            Xiang J, Zen K and Yao B.
  TITLE     HIF-1alpha drives resistance to ferroptosis in solid tumors by
            promoting lactate production and activating SLC1A1
  JOURNAL   Cell Rep 42 (8), 112945 (2023)
   PUBMED   37542723
  REMARK    GeneRIF: HIF-1alpha drives resistance to ferroptosis in solid
            tumors by promoting lactate production and activating SLC1A1.
REFERENCE   3  (residues 1 to 824)
  AUTHORS   Dery KJ, Kojima H, Kageyama S, Kadono K, Hirao H, Cheng B, Zhai Y,
            Farmer DG, Kaldas FM, Yuan X, Eltzschig HK and Kupiec-Weglinski JW.
  TITLE     Alternative splicing of CEACAM1 by hypoxia-inducible factor-1alpha
            enhances tolerance to hepatic ischemia in mice and humans
  JOURNAL   Sci Transl Med 15 (707), eadf2059 (2023)
   PUBMED   37531413
  REMARK    GeneRIF: Alternative splicing of CEACAM1 by hypoxia-inducible
            factor-1alpha enhances tolerance to hepatic ischemia in mice and
            humans.
REFERENCE   4  (residues 1 to 824)
  AUTHORS   Guo Z, Yu X, Zhao S, Zhong X, Huang D, Feng R, Li P, Fang Z, Hu Y,
            Zhang Z, Abdurahman M, Huang L, Zhao Y, Wang X, Ge J and Li H.
  TITLE     SIRT6 deficiency in endothelial cells exacerbates oxidative stress
            by enhancing HIF1alpha accumulation and H3K9 acetylation at the
            Ero1alpha promoter
  JOURNAL   Clin Transl Med 13 (8), e1377 (2023)
   PUBMED   37598403
  REMARK    GeneRIF: SIRT6 deficiency in endothelial cells exacerbates
            oxidative stress by enhancing HIF1alpha accumulation and H3K9
            acetylation at the Ero1alpha promoter.
REFERENCE   5  (residues 1 to 824)
  AUTHORS   Zhang G, Liu B, Yang Y, Xie S, Chen L, Luo H, Zhong J, Wei Y, Guo
            F, Gan J, Zhu F, Xu L, Li Q, Shen Y, Zhang H, Liu Y, Li R, Deng H
            and Yang H.
  TITLE     Mitochondrial UQCC3 controls embryonic and tumor angiogenesis by
            regulating VEGF expression
  JOURNAL   iScience 26 (8), 107370 (2023)
   PUBMED   37539028
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 824)
  AUTHORS   Li H, Ko HP and Whitlock JP.
  TITLE     Induction of phosphoglycerate kinase 1 gene expression by hypoxia.
            Roles of Arnt and HIF1alpha
  JOURNAL   J Biol Chem 271 (35), 21262-21267 (1996)
   PUBMED   8702901
REFERENCE   7  (residues 1 to 824)
  AUTHORS   Wood SM, Gleadle JM, Pugh CW, Hankinson O and Ratcliffe PJ.
  TITLE     The role of the aryl hydrocarbon receptor nuclear translocator
            (ARNT) in hypoxic induction of gene expression. Studies in
            ARNT-deficient cells
  JOURNAL   J Biol Chem 271 (25), 15117-15123 (1996)
   PUBMED   8662957
REFERENCE   8  (residues 1 to 824)
  AUTHORS   Semenza GL, Rue EA, Iyer NV, Pang MG and Kearns WG.
  TITLE     Assignment of the hypoxia-inducible factor 1alpha gene to a region
            of conserved synteny on mouse chromosome 12 and human chromosome
            14q
  JOURNAL   Genomics 34 (3), 437-439 (1996)
   PUBMED   8786149
REFERENCE   9  (residues 1 to 824)
  AUTHORS   Wenger RH, Rolfs A, Marti HH, Guenet JL and Gassmann M.
  TITLE     Nucleotide sequence, chromosomal assignment and mRNA expression of
            mouse hypoxia-inducible factor-1 alpha
  JOURNAL   Biochem Biophys Res Commun 223 (1), 54-59 (1996)
   PUBMED   8660378
REFERENCE   10 (residues 1 to 824)
  AUTHORS   Obara N and Takeda M.
  TITLE     Expression of neural cell adhesion molecule (NCAM) during the first
            molar development in the mouse
  JOURNAL   Anat Embryol (Berl) 187 (3), 209-219 (1993)
   PUBMED   8470821
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124712.5.
            
            On Jun 6, 2023 this sequence version replaced XP_036013089.1.
            
            Summary: This gene encodes the alpha subunit which, along with the
            beta subunit, forms a heterodimeric transcription factor that
            regulates the cellular and developmental response to reduced oxygen
            tension. The transcription factor has been shown to regulate genes
            involved in several biological processes, including erythropoiesis
            and angiogenesis which aid in increased delivery of oxygen to
            hypoxic regions. The transcription factor also plays a role in the
            induction of genes involved in cell proliferation and survival,
            energy metabolism, apoptosis, and glucose and iron metabolism.
            Alternative splicing results in multiple transcript variants
            encoding different isoforms. [provided by RefSeq, Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.253033.1,
                                           SRR17253014.4874676.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..824
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 31.99 cM"
     Protein         1..824
                     /product="hypoxia-inducible factor 1-alpha isoform 4"
                     /note="hypoxia-inducible factor 1-alpha; ARNT-interacting
                     protein"
                     /calculated_mol_wt=92126
     Region          1..71
                     /region_name="bHLH-PAS_HIF1a_PASD8"
                     /note="basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS)
                     domain found in hypoxia-inducible factor 1-alpha (HIF1a)
                     and similar proteins; cd19727"
                     /db_xref="CDD:381570"
     Site            order(6..7,9..11,14..15,17..18,43..44)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381570"
     Site            order(20..21,23..24,27..28,31..32,43..45,48..49,52,55..56,
                     59)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:381570"
     Region          81..136
                     /region_name="PAS"
                     /note="PAS domain; smart00091"
                     /db_xref="CDD:214512"
     Region          242..327
                     /region_name="PAS_3"
                     /note="PAS fold; pfam08447"
                     /db_xref="CDD:430001"
     Site            order(243,247,253,266..269,295,300)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:238075"
     Site            order(263,267,275,278..279,307,309)
                     /site_type="other"
                     /note="heme pocket [chemical binding]"
                     /db_xref="CDD:238075"
     Region          552..581
                     /region_name="HIF-1"
                     /note="Hypoxia-inducible factor-1; pfam11413"
                     /db_xref="CDD:431874"
     Region          787..823
                     /region_name="HIF-1a_CTAD"
                     /note="HIF-1 alpha C terminal transactivation domain;
                     pfam08778"
                     /db_xref="CDD:430212"
     CDS             1..824
                     /gene="Hif1a"
                     /gene_synonym="bHLHe78; HIF-1-alpha; HIF1-alpha;
                     HIF1alpha; MOP1"
                     /coded_by="NM_001422141.1:89..2563"
                     /note="isoform 4 is encoded by transcript variant 4"
                     /db_xref="GeneID:15251"
                     /db_xref="MGI:MGI:106918"
ORIGIN      
        1 msserrkeks rdaarsrrsk esevfyelah qlplphnvss hldkasvmrl tisylrvrkl
       61 ldaggldsed emkaqmdcfy lkaldgfvmv ltddgdmvyi sdnvnkymgl tqfeltghsv
      121 fdfthpcdhe emremlthrn gpvrkgkeln tqrsfflrmk ctltsrgrtm niksatwkvl
      181 hctghihvyd tnsnqpqcgy kkppmtclvl icepiphpsn ieipldsktf lsrhsldmkf
      241 sycderitel mgyepeellg rsiyeyyhal dsdhltkthh dmftkgqvtt gqyrmlakrg
      301 gyvwvetqat viyntknsqp qcivcvnyvv sgiiqhdlif slqqtesvlk pvessdmkmt
      361 qlftkvesed tsclfdklkk epdaltllap aagdtiisld fgsddteted qqledvplyn
      421 dvmfpssnek lninlamspl pssetpkplr ssadpalnqe valklesspe slglsftmpq
      481 iqdqpaspsd gstrqssper llqenvntpn fsqpnspsey cfdvdsdmvn vfklelvekl
      541 faedteaknp fstqdtdldl emlapyipmd ddfqlrsfdq lsplesnsps ppsmstvtgf
      601 qqtqlqkpti tatatttatt desktetkdn kedikilias psstqvpqet ttakasaysg
      661 thsrtaspdr agkrvieqtd kahprslnls atlnqrntvp eeelnpktia sqnaqrkrkm
      721 ehdgslfqaa gigtllqqpg dcaptmslsw krvkgfisse qngteqktii lipsdlacrl
      781 lgqsmdesgl pqltsydcev napiqgsrnl lqgeellral dqvn
//
LOCUS       NP_001342696             544 aa            linear   ROD 09-OCT-2023
DEFINITION  solute carrier family 22 member 2 isoform 2 [Mus musculus].
ACCESSION   NP_001342696 XP_011244498
VERSION     NP_001342696.1
DBSOURCE    REFSEQ: accession NM_001355767.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 544)
  AUTHORS   Orrico-Sanchez A, Guiard BP, Manta S, Callebert J, Launay JM, Louis
            F, Paccard A, Gruszczynski C, Betancur C, Vialou V and Gautron S.
  TITLE     Organic cation transporter 2 contributes to SSRI antidepressant
            efficacy by controlling tryptophan availability in the brain
  JOURNAL   Transl Psychiatry 13 (1), 302 (2023)
   PUBMED   37775532
  REMARK    GeneRIF: Organic cation transporter 2 contributes to SSRI
            antidepressant efficacy by controlling tryptophan availability in
            the brain.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 544)
  AUTHORS   Hucke A, Schroter R, Ceresa C, Chiorazzi A, Canta A, Semperboni S,
            Marmiroli P, Cavaletti G, Gess B and Ciarimboli G.
  TITLE     Role of Mouse Organic Cation Transporter 2 for Nephro- and
            Peripheral Neurotoxicity Induced by Chemotherapeutic Treatment with
            Cisplatin
  JOURNAL   Int J Mol Sci 24 (14), 11486 (2023)
   PUBMED   37511245
  REMARK    GeneRIF: Role of Mouse Organic Cation Transporter 2 for Nephro- and
            Peripheral Neurotoxicity Induced by Chemotherapeutic Treatment with
            Cisplatin.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 544)
  AUTHORS   La Manno G, Siletti K, Furlan A, Gyllborg D, Vinsland E, Mossi
            Albiach A, Mattsson Langseth C, Khven I, Lederer AR, Dratva LM,
            Johnsson A, Nilsson M, Lonnerberg P and Linnarsson S.
  TITLE     Molecular architecture of the developing mouse brain
  JOURNAL   Nature 596 (7870), 92-96 (2021)
   PUBMED   34321664
REFERENCE   4  (residues 1 to 544)
  AUTHORS   Martinez ME and Hernandez A.
  TITLE     The Type 3 Deiodinase Is a Critical Modulator of Thyroid Hormone
            Sensitivity in the Fetal Brain
  JOURNAL   Front Neurosci 15, 703730 (2021)
   PUBMED   34248495
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 544)
  AUTHORS   Morse BL, Chen LH, Catlow JT, Fallon JK, Smith PC and Hillgren KM.
  TITLE     Expansion of Knowledge on OCT1 Variant Activity In Vitro and In
            Vivo Using Oct1/2-/- Mice
  JOURNAL   Front Pharmacol 12, 631793 (2021)
   PUBMED   33658943
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 544)
  AUTHORS   Sleutels F, Zwart R and Barlow DP.
  TITLE     The non-coding Air RNA is required for silencing autosomal
            imprinted genes
  JOURNAL   Nature 415 (6873), 810-813 (2002)
   PUBMED   11845212
  REMARK    GeneRIF: Slc22a2 is one of three imprinted genes on chromosome 17
            that is expressed from the maternal allele. A non-coding Air RNA is
            required for repression of all three genes on the paternal allele.
REFERENCE   7  (residues 1 to 544)
  AUTHORS   Vallette-Kasic S, Pellegrini-Bouiller I, Sampieri F, Gunz G, Diaz
            A, Radovick S, Enjalbert A and Brue T.
  TITLE     Combined pituitary hormone deficiency due to the F135C human Pit-1
            (pituitary-specific factor 1) gene mutation: functional and
            structural correlates
  JOURNAL   Mol Endocrinol 15 (3), 411-420 (2001)
   PUBMED   11222742
REFERENCE   8  (residues 1 to 544)
  AUTHORS   Mooslehner KA and Allen ND.
  TITLE     Cloning of the mouse organic cation transporter 2 gene, Slc22a2,
            from an enhancer-trap transgene integration locus
  JOURNAL   Mamm Genome 10 (3), 218-224 (1999)
   PUBMED   10051314
REFERENCE   9  (residues 1 to 544)
  AUTHORS   Verhaagh S, Schweifer N, Barlow DP and Zwart R.
  TITLE     Cloning of the mouse and human solute carrier 22a3
            (Slc22a3/SLC22A3) identifies a conserved cluster of three organic
            cation transporters on mouse chromosome 17 and human 6q26-q27
  JOURNAL   Genomics 55 (2), 209-218 (1999)
   PUBMED   9933568
REFERENCE   10 (residues 1 to 544)
  AUTHORS   Koehler MR, Wissinger B, Gorboulev V, Koepsell H and Schmid M.
  TITLE     The two human organic cation transporter genes SLC22A1 and SLC22A2
            are located on chromosome 6q26
  JOURNAL   Cytogenet Cell Genet 79 (3-4), 198-200 (1997)
   PUBMED   9605850
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC167817.4, AK143892.1 and AK052658.1.
            
            On Sep 27, 2017 this sequence version replaced XP_011244498.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK052658.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            imprinted gene :: PMID: 11845212
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..544
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 8.61 cM"
     Protein         1..544
                     /product="solute carrier family 22 member 2 isoform 2"
                     /note="organic cation transporter 2; solute carrier family
                     22 member 2"
                     /calculated_mol_wt=60413
     Region          12..525
                     /region_name="2A0119"
                     /note="cation transport protein; TIGR00898"
                     /db_xref="CDD:273328"
     Site            22..42
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O70577.1)"
     Site            71
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O70577.1)"
     Site            151..171
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O70577.1)"
     Site            178..198
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O70577.1)"
     Site            211..231
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O70577.1)"
     Site            239..259
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O70577.1)"
     Site            264..284
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O70577.1)"
     Region          284..288
                     /region_name="Proline-rich sequence.
                     /evidence=ECO:0000250|UniProtKB:O15244"
                     /note="propagated from UniProtKB/Swiss-Prot (O70577.1)"
     Site            349..369
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O70577.1)"
     Site            376..396
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O70577.1)"
     Site            405..425
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O70577.1)"
     Site            433..453
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O70577.1)"
     Site            451
                     /site_type="other"
                     /note="Involved in recognition of organic cations and
                     participates in structural changes that occur during
                     translocation of organic cations.
                     /evidence=ECO:0000250|UniProtKB:Q9R0W2; propagated from
                     UniProtKB/Swiss-Prot (O70577.1)"
     Site            465..485
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O70577.1)"
     Site            495..515
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O70577.1)"
     CDS             1..544
                     /gene="Slc22a2"
                     /gene_synonym="mOCT2; Oct2; Orct2"
                     /coded_by="NM_001355767.1:93..1727"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS88992.1"
                     /db_xref="GeneID:20518"
                     /db_xref="MGI:MGI:1335072"
ORIGIN      
        1 mptvddileh igefhlfqkq tffllallsg aftpiyvgiv flgftpnhhc rspgvaelsq
       61 rcgwspaeel nytvpglgsa gevsflsqcm ryevdwnqst ldcvdplssl aanrshlpls
      121 pcehgwvydt pgssivtefn lvcahswmld lfqslvnvgf figavgigyl adrfgrkfcl
      181 lvtilinais gvlmaispny awmlvfrflq glvskagwli gyilitefvg lgyrrtvgic
      241 yqiaftvgll ilagvayalp nwrwlqfavt lpnfcfllyf wcipesprwl isqnknakam
      301 kiikhiakkn gksvpvslqs ltadedtgmk lnpsfldlvr tpqirkhtli lmynwftssv
      361 lyqglimhmg lagdniyldf fysalvefpa afiiiltidr igrrypwavs nmvagaacla
      421 svfipddlqw lkitvaclgr mgitiayemv clvnaelypt yirnlavlvc ssmcdiggiv
      481 tpflvyrltd iwlefplvvf avvglvaggl vlllpetkgk alpetiedae kmqslgrlvq
      541 tvch
//
LOCUS       NP_031557                299 aa            linear   ROD 09-OCT-2023
DEFINITION  prohibitin-2 [Mus musculus].
ACCESSION   NP_031557
VERSION     NP_031557.2
DBSOURCE    REFSEQ: accession NM_007531.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 299)
  AUTHORS   Yang M, Abudureyimu M, Wang X, Zhou Y, Zhang Y and Ren J.
  TITLE     PHB2 ameliorates Doxorubicin-induced cardiomyopathy through
            interaction with NDUFV2 and restoration of mitochondrial complex I
            function
  JOURNAL   Redox Biol 65, 102812 (2023)
   PUBMED   37451140
REFERENCE   2  (residues 1 to 299)
  AUTHORS   Cai C, Li Z, Zheng Z, Guo Z, Li Q, Deng S, Shi N, Ou Q, Zhou H, Guo
            Z, Chen Z and Zhu H.
  TITLE     Pgam5-mediated PHB2 dephosphorylation contributes to
            endotoxemia-induced myocardial dysfunction by inhibiting mitophagy
            and the mitochondrial unfolded protein response
  JOURNAL   Int J Biol Sci 19 (14), 4657-4671 (2023)
   PUBMED   37781037
  REMARK    GeneRIF: Pgam5-mediated PHB2 dephosphorylation contributes to
            endotoxemia-induced myocardial dysfunction by inhibiting mitophagy
            and the mitochondrial unfolded protein response.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 299)
  AUTHORS   Jia Y, Mao C, Ma Z, Huang J, Li W, Ma X, Zhang S, Li M, Yu F, Sun
            Y, Chen J, Feng J, Zhou Y, Xu Q, Zhao L, Fu Y and Kong W.
  TITLE     PHB2 Maintains the Contractile Phenotype of VSMCs by Counteracting
            PKM2 Splicing
  JOURNAL   Circ Res 131 (10), 807-824 (2022)
   PUBMED   36200440
  REMARK    GeneRIF: PHB2 Maintains the Contractile Phenotype of VSMCs by
            Counteracting PKM2 Splicing.
REFERENCE   4  (residues 1 to 299)
  AUTHORS   Li L, Krznar P, Erban A, Agazzi A, Martin-Levilain J, Supale S,
            Kopka J, Zamboni N and Maechler P.
  TITLE     Metabolomics Identifies a Biomarker Revealing In Vivo Loss of
            Functional beta-Cell Mass Before Diabetes Onset
  JOURNAL   Diabetes 68 (12), 2272-2286 (2019)
   PUBMED   31537525
REFERENCE   5  (residues 1 to 299)
  AUTHORS   Li L, Martin-Levilain J, Jimenez-Sanchez C, Karaca M, Foti M,
            Martinou JC and Maechler P.
  TITLE     In vivo stabilization of OPA1 in hepatocytes potentiates
            mitochondrial respiration and gluconeogenesis in a
            prohibitin-dependent way
  JOURNAL   J Biol Chem 294 (34), 12581-12598 (2019)
   PUBMED   31285263
REFERENCE   6  (residues 1 to 299)
  AUTHORS   Da Cruz S, Xenarios I, Langridge J, Vilbois F, Parone PA and
            Martinou JC.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   7  (residues 1 to 299)
  AUTHORS   Coates PJ, Nenutil R, McGregor A, Picksley SM, Crouch DH, Hall PA
            and Wright EG.
  TITLE     Mammalian prohibitin proteins respond to mitochondrial stress and
            decrease during cellular senescence
  JOURNAL   Exp Cell Res 265 (2), 262-273 (2001)
   PUBMED   11302691
REFERENCE   8  (residues 1 to 299)
  AUTHORS   Chu CC and Paul WE.
  TITLE     Expressed genes in interleukin-4 treated B cells identified by cDNA
            representational difference analysis
  JOURNAL   Mol Immunol 35 (8), 487-502 (1998)
   PUBMED   9798653
REFERENCE   9  (residues 1 to 299)
  AUTHORS   Ansari-Lari MA, Oeltjen JC, Schwartz S, Zhang Z, Muzny DM, Lu J,
            Gorrell JH, Chinault AC, Belmont JW, Miller W and Gibbs RA.
  TITLE     Comparative sequence analysis of a gene-rich cluster at human
            chromosome 12p13 and its syntenic region in mouse chromosome 6
  JOURNAL   Genome Res 8 (1), 29-40 (1998)
   PUBMED   9445485
REFERENCE   10 (residues 1 to 299)
  AUTHORS   Terashima M, Kim KM, Adachi T, Nielsen PJ, Reth M, Kohler G and
            Lamers MC.
  TITLE     The IgM antigen receptor of B lymphocytes is associated with
            prohibitin and a prohibitin-related protein
  JOURNAL   EMBO J 13 (16), 3782-3792 (1994)
   PUBMED   8070406
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB595613.1, AK132058.1, AK152375.1 and AK002334.1.
            
            On Mar 8, 2007 this sequence version replaced NP_031557.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK151952.1, AK132058.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..299
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 59.17 cM"
     Protein         1..299
                     /product="prohibitin-2"
                     /note="repressor of estrogen receptor activity; B-cell
                     receptor-associated protein BAP37; B-cell
                     receptor-associated protein 37"
                     /calculated_mol_wt=33165
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:Q99623; propagated from
                     UniProtKB/Swiss-Prot (O35129.1)"
     Region          19..49
                     /region_name="Necessary for transcriptional repression.
                     /evidence=ECO:0000250|UniProtKB:Q99623"
                     /note="propagated from UniProtKB/Swiss-Prot (O35129.1)"
     Region          40..235
                     /region_name="SPFH_prohibitin"
                     /note="Prohibitin family; SPFH (stomatin, prohibitin,
                     flotillin, and HflK/C) superfamily; cd03401"
                     /db_xref="CDD:259799"
     Site            128
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q99623; propagated from
                     UniProtKB/Swiss-Prot (O35129.1)"
     Site            147
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (O35129.1)"
     Region          150..174
                     /region_name="Necessary for transcriptional repression.
                     /evidence=ECO:0000250|UniProtKB:Q99623"
                     /note="propagated from UniProtKB/Swiss-Prot (O35129.1)"
     Site            151
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q99623; propagated from
                     UniProtKB/Swiss-Prot (O35129.1)"
     Site            200
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (O35129.1)"
     Site            236
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (O35129.1)"
     Site            250
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q99623; propagated from
                     UniProtKB/Swiss-Prot (O35129.1)"
     Site            262
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (O35129.1)"
     CDS             1..299
                     /gene="Phb2"
                     /gene_synonym="BAP; Bap37; Bcap37; REA"
                     /coded_by="NM_007531.2:149..1048"
                     /db_xref="CCDS:CCDS39627.1"
                     /db_xref="GeneID:12034"
                     /db_xref="MGI:MGI:102520"
ORIGIN      
        1 maqnlkdlag rlpagprgmg talklllgag avaygvresv ftvegghrai ffnriggvqq
       61 dtilaeglhf ripwfqypii ydirarprki ssptgskdlq mvnislrvls rpnaqelpsm
      121 yqrlgldyee rvlpsivnev lksvvakfna sqlitqraqv sllirrelte rakdfslild
      181 dvaitelsfs reytaaveak qvaqqeaqra qflvekakqe qrqkivqaeg eaeaakmlge
      241 alsknpgyik lrkiraaqni sktiatsqnr iyltadnlvl nlqdesftrg sdslikgkk
//
LOCUS       NP_079874                115 aa            linear   ROD 09-OCT-2023
DEFINITION  pancreatic progenitor cell differentiation and proliferation factor
            isoform a [Mus musculus].
ACCESSION   NP_079874
VERSION     NP_079874.1
DBSOURCE    REFSEQ: accession NM_025598.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 115)
  AUTHORS   Wang YK, Ma N, Xu S, Huang JY, Ni QZ, Cao HJ, Zheng QW, Zhu B, Xia
            J, Zhang FK, Ding XF, Qiu XS, Chen TW, Wang K, Chen W, Li ZG, Cheng
            SQ, Xie D and Li JJ.
  TITLE     PPDPF suppresses the development of hepatocellular carcinoma
            through TRIM21-mediated ubiquitination of RIPK1
  JOURNAL   Cell Rep 42 (4), 112340 (2023)
   PUBMED   37027301
  REMARK    GeneRIF: PPDPF suppresses the development of hepatocellular
            carcinoma through TRIM21-mediated ubiquitination of RIPK1.
REFERENCE   2  (residues 1 to 115)
  AUTHORS   Ni QZ, Zhu B, Ji Y, Zheng QW, Liang X, Ma N, Jiang H, Zhang FK,
            Shang YR, Wang YK, Xu S, Zhang EB, Yuan YM, Chen TW, Yin FF, Cao
            HJ, Huang JY, Xia J, Ding XF, Qiu XS, Ding K, Song C, Zhou WT, Wu
            M, Wang K, Lui R, Lin Q, Chen W, Li ZG, Cheng SQ, Wang XF, Xie D
            and Li JJ.
  TITLE     PPDPF Promotes the Development of Mutant KRAS-Driven Pancreatic
            Ductal Adenocarcinoma by Regulating the GEF Activity of SOS1
  JOURNAL   Adv Sci (Weinh) 10 (2), e2202448 (2023)
   PUBMED   36453576
  REMARK    GeneRIF: PPDPF Promotes the Development of Mutant KRAS-Driven
            Pancreatic Ductal Adenocarcinoma by Regulating the GEF Activity of
            SOS1.
REFERENCE   3  (residues 1 to 115)
  AUTHORS   Zheng QW, Ni QZ, Zhu B, Liang X, Ma N, Wang YK, Xu S, Cao HJ, Xia
            J, Zhang FK, Zhang EB, Qiu XS, Ding XF, Qiu L, Zhang XL, Dong ZH,
            Li ZG, Zhang XL, Xie D and Li JJ.
  TITLE     PPDPF promotes lung adenocarcinoma progression via inhibiting
            apoptosis and NK cell-mediated cytotoxicity through STAT3
  JOURNAL   Oncogene 41 (36), 4244-4256 (2022)
   PUBMED   35906391
  REMARK    Erratum:[Oncogene. 2023 Aug;42(35):2655-2656. PMID: 37491607]
REFERENCE   4  (residues 1 to 115)
  AUTHORS   Ma N, Wang YK, Xu S, Ni QZ, Zheng QW, Zhu B, Cao HJ, Jiang H, Zhang
            FK, Yuan YM, Zhang EB, Chen TW, Xia J, Ding XF, Chen ZH, Zhang XP,
            Wang K, Cheng SQ, Qiu L, Li ZG, Yu YC, Wang XF, Zhou B, Li JJ and
            Xie D.
  TITLE     PPDPF alleviates hepatic steatosis through inhibition of mTOR
            signaling
  JOURNAL   Nat Commun 12 (1), 3059 (2021)
   PUBMED   34031390
  REMARK    GeneRIF: PPDPF alleviates hepatic steatosis through inhibition of
            mTOR signaling.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 115)
  AUTHORS   Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK,
            Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L,
            Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre
            JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A,
            Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ,
            Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall
            S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA,
            Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR,
            Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana
            S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, MacArthur DG,
            Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC,
            Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL,
            de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown
            SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bucan M and Murray
            SA.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. PMID: 29144450]
REFERENCE   6  (residues 1 to 115)
  AUTHORS   Lewandowski JP, Du F, Zhang S, Powell MB, Falkenstein KN, Ji H and
            Vokes SA.
  TITLE     Spatiotemporal regulation of GLI target genes in the mammalian limb
            bud
  JOURNAL   Dev Biol 406 (1), 92-103 (2015)
   PUBMED   26238476
REFERENCE   7  (residues 1 to 115)
  AUTHORS   Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H,
            Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T,
            Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P,
            Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ,
            Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD,
            Flicek P, Skarnes WC, Mallon AM and Parkinson H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL450341.10 and BC058516.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a). Variants 1 and 2
            both encode the same isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK003282.1, AK154758.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..115
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 103.62 cM"
     Protein         1..115
                     /product="pancreatic progenitor cell differentiation and
                     proliferation factor isoform a"
                     /note="exocrine differentiation and proliferation factor"
                     /calculated_mol_wt=12129
     Region          1..111
                     /region_name="PPDFL"
                     /note="Differentiation and proliferation regulator;
                     pfam15060"
                     /db_xref="CDD:434428"
     Site            9
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H3Y8; propagated from
                     UniProtKB/Swiss-Prot (Q9CR37.1)"
     Region          21..46
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CR37.1)"
     Region          73..115
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CR37.1)"
     CDS             1..115
                     /gene="Ppdpf"
                     /gene_synonym="0610012G23Rik; 2610317A05Rik;
                     2700038C09Rik; 3110053G12Rik"
                     /coded_by="NM_025598.3:341..688"
                     /note="isoform a is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS17202.1"
                     /db_xref="GeneID:66496"
                     /db_xref="MGI:MGI:1913746"
ORIGIN      
        1 maaipssgsl vathdyyrrr lgsssssssg gsaeypgdav lqspglpkad pghwwasfff
       61 gkstlpfmtt vlespersae spqvsrspmt cgltpetmkq qpvihsgqtn prdls
//
LOCUS       NP_032630                750 aa            linear   ROD 09-OCT-2023
DEFINITION  neprilysin [Mus musculus].
ACCESSION   NP_032630
VERSION     NP_032630.2
DBSOURCE    REFSEQ: accession NM_008604.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 750)
  AUTHORS   Esser N, Mongovin SM, Mundinger TO, Barrow BM and Zraika S.
  TITLE     Neprilysin deficiency reduces hepatic gluconeogenesis in high
            fat-fed mice
  JOURNAL   Peptides 168, 171076 (2023)
   PUBMED   37572792
  REMARK    GeneRIF: Neprilysin deficiency reduces hepatic gluconeogenesis in
            high fat-fed mice.
REFERENCE   2  (residues 1 to 750)
  AUTHORS   Esser N, Mundinger TO, Barrow BM and Zraika S.
  TITLE     Acute Inhibition of Intestinal Neprilysin Enhances Insulin
            Secretion via GLP-1 Receptor Signaling in Male Mice
  JOURNAL   Endocrinology 164 (5) (2023)
   PUBMED   36964914
  REMARK    GeneRIF: Acute Inhibition of Intestinal Neprilysin Enhances Insulin
            Secretion via GLP-1 Receptor Signaling in Male Mice.
REFERENCE   3  (residues 1 to 750)
  AUTHORS   Ortiz C, Klein S, Reul WH, Magdaleno F, Groschl S, Dietrich P,
            Schierwagen R, Uschner FE, Torres S, Hieber C, Meier C, Kraus N,
            Tyc O, Brol M, Zeuzem S, Welsch C, Poglitsch M, Hellerbrand C,
            Alfonso-Prieto M, Mira F, Keller UAD, Tetzner A, Moore A, Walther T
            and Trebicka J.
  TITLE     Neprilysin-dependent neuropeptide Y cleavage in the liver promotes
            fibrosis by blocking NPY-receptor 1
  JOURNAL   Cell Rep 42 (2), 112059 (2023)
   PUBMED   36729833
  REMARK    GeneRIF: Neprilysin-dependent neuropeptide Y cleavage in the liver
            promotes fibrosis by blocking NPY-receptor 1.
REFERENCE   4  (residues 1 to 750)
  AUTHORS   Chen Y and Burnett JC Jr.
  TITLE     Biochemistry, Therapeutics, and Biomarker Implications of
            Neprilysin in Cardiorenal Disease
  JOURNAL   Clin Chem 63 (1), 108-115 (2017)
   PUBMED   28062615
  REMARK    Review article
REFERENCE   5  (residues 1 to 750)
  AUTHORS   Bayes-Genis A, Barallat J and Richards AM.
  TITLE     A Test in Context: Neprilysin: Function, Inhibition, and Biomarker
  JOURNAL   J Am Coll Cardiol 68 (6), 639-653 (2016)
   PUBMED   27491909
  REMARK    Review article
REFERENCE   6  (residues 1 to 750)
  AUTHORS   Turner AJ and Nalivaeva NN.
  TITLE     Proteinase dysbalance in pathology: the neprilysin (NEP) and
            angiotensin-converting enzyme (ACE) families
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 52 (4), 40-48 (2006)
   PUBMED   17543197
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   7  (residues 1 to 750)
  AUTHORS   Weil M, Itin A and Keshet E.
  TITLE     A role for mesenchyme-derived tachykinins in tooth and mammary
            gland morphogenesis
  JOURNAL   Development 121 (8), 2419-2428 (1995)
   PUBMED   7545574
REFERENCE   8  (residues 1 to 750)
  AUTHORS   Kalled SL, Siva N, Stein H and Reinherz EL.
  TITLE     The distribution of CD10 (NEP 24.11, CALLA) in humans and mice is
            similar in non-lymphoid organs but differs within the hematopoietic
            system: absence on murine T and B lymphoid progenitors
  JOURNAL   Eur J Immunol 25 (3), 677-687 (1995)
   PUBMED   7705396
REFERENCE   9  (residues 1 to 750)
  AUTHORS   Watson ML, Rao JK, Gilkeson GS, Ruiz P, Eicher EM, Pisetsky DS,
            Matsuzawa A, Rochelle JM and Seldin MF.
  TITLE     Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis
            gene to disease manifestations and renal disease-modifying loci
  JOURNAL   J Exp Med 176 (6), 1645-1656 (1992)
   PUBMED   1460423
REFERENCE   10 (residues 1 to 750)
  AUTHORS   Chen CY, Salles G, Seldin MF, Kister AE, Reinherz EL and Shipp MA.
  TITLE     Murine common acute lymphoblastic leukemia antigen (CD10 neutral
            endopeptidase 24.11). Molecular characterization, chromosomal
            localization, and modeling of the active site
  JOURNAL   J Immunol 148 (9), 2817-2825 (1992)
   PUBMED   1374101
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK031446.1 and AC121840.3.
            
            On Jun 9, 2003 this sequence version replaced NP_032630.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK031446.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..750
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 29.97 cM"
     Protein         1..750
                     /product="neprilysin"
                     /EC_number="3.4.24.11"
                     /note="common acute lymphoblastic leukemia antigen;
                     enkephalinase; atriopeptidase; neutral endopeptidase
                     24.11; skin fibroblast elastase"
                     /calculated_mol_wt=85571
     Site            4
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61391.3)"
     Site            6
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61391.3)"
     Region          16..23
                     /region_name="Stop-transfer sequence.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61391.3)"
     Site            29..51
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61391.3)"
     Region          77..748
                     /region_name="M13"
                     /note="Peptidase family M13 includes neprilysin and
                     endothelin-converting enzyme I; cd08662"
                     /db_xref="CDD:341056"
     Site            order(107,537,542..545,564,580..581,584..585,588,647,690,
                     693..694,711..712,718)
                     /site_type="active"
                     /db_xref="CDD:341056"
     Site            145
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19349973; propagated from
                     UniProtKB/Swiss-Prot (Q61391.3)"
     Site            211
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61391.3)"
     Site            285
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19349973; propagated from
                     UniProtKB/Swiss-Prot (Q61391.3)"
     Site            311
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19349973; propagated from
                     UniProtKB/Swiss-Prot (Q61391.3)"
     Site            325
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000250|UniProtKB:P08473; propagated from
                     UniProtKB/Swiss-Prot (Q61391.3)"
     Site            628
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000250|UniProtKB:P08473; propagated from
                     UniProtKB/Swiss-Prot (Q61391.3)"
     CDS             1..750
                     /gene="Mme"
                     /gene_synonym="6030454K05Rik; CALLA; CD10; NEP; SFE"
                     /coded_by="NM_008604.4:89..2341"
                     /db_xref="CCDS:CCDS17381.1"
                     /db_xref="GeneID:17380"
                     /db_xref="MGI:MGI:97004"
ORIGIN      
        1 mgrsesqmdi tdinapkpkk kqrwtpleis lsvlvlllti iavtmialya tyddgickss
       61 dciksaarli qnmdasvepc tdffkyacgg wlkrnvipet ssrysnfdil rdelevilkd
      121 vlqepktedi vavqkaktly rscinesaid srggqpllkl lpdiygwpva sdnwdqtygt
      181 swtaeksiaq lnskygkkvl inffvgtddk nstqhiihfd qprlglpsrd yyectgiyke
      241 actayvdfmi svarlirqeq slpidenqls lemnkvmele keianattkp edrndpmlly
      301 nkmtlaklqn nfslevngks fswsnftnei mstvniniqn eeevvvyape yltklkpilt
      361 kysprdlqnl mswrfimdlv sslsrnykes rnafrkalyg ttsetatwrr canyvngnme
      421 navgrlyvea afageskhvv edliaqirev fiqtlddltw mdaetkkkae ekalaikeri
      481 gypddiisne nklnneylel nyredeyfen iiqnlkfsqs kqlkklrekv dkdewisgaa
      541 vvnafyssgr nqivfpagil qppffsaqqs nslnyggigm vigheithgf ddngrnfnkd
      601 gdlvdwwtqq sannfkdqsq cmvyqygnfs wdlaggqhln gintlgenia dnggigqayr
      661 ayqnyvkkng eekllpgldl nhkqlfflnf aqvwcgtyrp eyavnsiktd vhspgnfrii
      721 gtlqnsaefa dafhcrknsy mnperkcrvw
//
LOCUS       NP_001003911            1615 aa            linear   ROD 09-OCT-2023
DEFINITION  A disintegrin and metalloproteinase with thrombospondin motifs 7
            isoform 1 precursor [Mus musculus].
ACCESSION   NP_001003911 XP_135041
VERSION     NP_001003911.2
DBSOURCE    REFSEQ: accession NM_001003911.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1615)
  AUTHORS   Sharifi MA, Wierer M, Dang TA, Milic J, Moggio A, Sachs N, von
            Scheidt M, Hinterdobler J, Muller P, Werner J, Stiller B,
            Aherrahrou Z, Erdmann J, Zaliani A, Graettinger M, Reinshagen J,
            Gul S, Gribbon P, Maegdefessel L, Bernhagen J, Sager HB, Mann M,
            Schunkert H and Kessler T.
  TITLE     ADAMTS-7 Modulates Atherosclerotic Plaque Formation by Degradation
            of TIMP-1
  JOURNAL   Circ Res 133 (8), 674-686 (2023)
   PUBMED   37675562
  REMARK    GeneRIF: ADAMTS-7 Modulates Atherosclerotic Plaque Formation by
            Degradation of TIMP-1.
REFERENCE   2  (residues 1 to 1615)
  AUTHORS   Gong Z, Huang J, Wang D, Yang S, Ma Z, Fu Y, Ma Q and Kong W.
  TITLE     ADAMTS-7 deficiency attenuates thoracic aortic aneurysm and
            dissection in mice
  JOURNAL   J Mol Med (Berl) 101 (3), 237-248 (2023)
   PUBMED   36662289
  REMARK    GeneRIF: ADAMTS-7 deficiency attenuates thoracic aortic aneurysm
            and dissection in mice.
REFERENCE   3  (residues 1 to 1615)
  AUTHORS   Ma Z, Mao C, Jia Y, Yu F, Xu P, Tan Y, Zou QH, Zhou XJ, Kong W and
            Fu Y.
  TITLE     ADAMTS7-Mediated Complement Factor H Degradation Potentiates
            Complement Activation to Contributing to Renal Injuries
  JOURNAL   J Am Soc Nephrol 34 (2), 291-308 (2023)
   PUBMED   36735376
  REMARK    GeneRIF: ADAMTS7-Mediated Complement Factor H Degradation
            Potentiates Complement Activation to Contributing to Renal
            Injuries.
REFERENCE   4  (residues 1 to 1615)
  AUTHORS   Jaiswal AK and Mishra A.
  TITLE     ADAMTS7 Attenuates House Dust Mite-Induced Airway Inflammation and
            Th2 Immune Responses
  JOURNAL   Lung 200 (3), 305-313 (2022)
   PUBMED   35503474
  REMARK    GeneRIF: ADAMTS7 Attenuates House Dust Mite-Induced Airway
            Inflammation and Th2 Immune Responses.
REFERENCE   5  (residues 1 to 1615)
  AUTHORS   Mizoguchi T, MacDonald BT, Bhandary B, Popp NR, Laprise D, Arduini
            A, Lai D, Zhu QM, Xing Y, Kaushik VK, Kathiresan S and Ellinor PT.
  TITLE     Coronary Disease Association With ADAMTS7 Is Due to Protease
            Activity
  JOURNAL   Circ Res 129 (4), 458-470 (2021)
   PUBMED   34176299
REFERENCE   6  (residues 1 to 1615)
  AUTHORS   Lai Y, Bai X, Zhao Y, Tian Q, Liu B, Lin EA, Chen Y, Lee B,
            Appleton CT, Beier F, Yu XP and Liu CJ.
  TITLE     ADAMTS-7 forms a positive feedback loop with TNF-alpha in the
            pathogenesis of osteoarthritis
  JOURNAL   Ann Rheum Dis 73 (8), 1575-1584 (2014)
   PUBMED   23928557
  REMARK    GeneRIF: ADAMTS-7 and TNF-alpha form a positive feedback loop in
            the regulation of cartilage degradation and osteoarthritis
            progression.
REFERENCE   7  (residues 1 to 1615)
  AUTHORS   Du J, Takeuchi H, Leonhard-Melief C, Shroyer KR, Dlugosz M,
            Haltiwanger RS and Holdener BC.
  TITLE     O-fucosylation of thrombospondin type 1 repeats restricts
            epithelial to mesenchymal transition (EMT) and maintains epiblast
            pluripotency during mouse gastrulation
  JOURNAL   Dev Biol 346 (1), 25-38 (2010)
   PUBMED   20637190
REFERENCE   8  (residues 1 to 1615)
  AUTHORS   Bai XH, Wang DW, Kong L, Zhang Y, Luan Y, Kobayashi T, Kronenberg
            HM, Yu XP and Liu CJ.
  TITLE     ADAMTS-7, a direct target of PTHrP, adversely regulates
            endochondral bone growth by associating with and inactivating GEP
            growth factor
  JOURNAL   Mol Cell Biol 29 (15), 4201-4219 (2009)
   PUBMED   19487464
  REMARK    GeneRIF: Findings demonstrate that ADAMTS-7, a direct target of
            PTHrP signaling, negatively regulates endochondral bone formation
            by associating with and inactivating GEP chondrogenic growth
            factor.
REFERENCE   9  (residues 1 to 1615)
  AUTHORS   Somerville RP, Longpre JM, Apel ED, Lewis RM, Wang LW, Sanes JR,
            Leduc R and Apte SS.
  TITLE     ADAMTS7B, the full-length product of the ADAMTS7 gene, is a
            chondroitin sulfate proteoglycan containing a mucin domain
  JOURNAL   J Biol Chem 279 (34), 35159-35175 (2004)
   PUBMED   15192113
  REMARK    GeneRIF: ADAMTS7B has a domain organization with a total of eight
            thrombospondin type 1 repeats in its ancillary domain. Of these,
            seven are arranged in two distinct clusters that are separated by a
            mucin domain
REFERENCE   10 (residues 1 to 1615)
  AUTHORS   Hurskainen TL, Hirohata S, Seldin MF and Apte SS.
  TITLE     ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of
            zinc metalloproteases. General features and genomic distribution of
            the ADAM-TS family
  JOURNAL   J Biol Chem 274 (36), 25555-25563 (1999)
   PUBMED   10464288
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY347798.1, BC076575.1,
            CB246893.1 and BC058991.1.
            
            On Mar 20, 2007 this sequence version replaced NP_001003911.1.
            
            Summary: This gene encodes a member of 'a disintegrin and
            metalloproteinase with thrombospondin motifs' (ADAMTS) family of
            multi-domain matrix-associated metalloendopeptidases that have
            diverse roles in tissue morphogenesis and pathophysiological
            remodeling, in inflammation and in vascular biology. The encoded
            preproprotein undergoes proteolytic processing to generate an
            active, zinc-dependent enzyme that degrades cartilage oligomeric
            matrix protein. The deficiency of the encoded protein decreases
            atherosclerosis in genetically hyperlipidemic mice and in response
            to vascular injury. Alternative splicing results in multiple
            transcript variants encoding different isoforms, some of which may
            undergo similar processing. [provided by RefSeq, May 2016].
            
            Transcript Variant: This variant (1) encodes isoform (1). This
            isoform (1) may undergo proteolytic processing similar to isoform
            4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC141173.1, SRR9219380.40329.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1615
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 47.46 cM"
     Protein         1..1615
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 7 isoform 1 precursor"
                     /EC_number="3.4.24.-"
                     /note="a disintegrin and metalloproteinase with
                     thrombospondin motifs 7; COMPase; a disintegrin-like and
                     metalloprotease (reprolysin type) with thrombospondin type
                     1 motif, 7; a disintegrin-like and metallopeptidase
                     (reprolysin type) with thrombospondin type 1 motif, 7"
                     /calculated_mol_wt=175298
     sig_peptide     1..24
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=2433
     Region          34..174
                     /region_name="Pep_M12B_propep"
                     /note="Reprolysin family propeptide; pfam01562"
                     /db_xref="CDD:426325"
     Region          226..434
                     /region_name="ZnMc_ADAMTS_like"
                     /note="Zinc-dependent metalloprotease, ADAMTS_like
                     subgroup. ADAMs (A Disintegrin And Metalloprotease) are
                     glycoproteins, which play roles in cell signaling, cell
                     fusion, and cell-cell interactions. This particular
                     subfamily represents domain architectures that...;
                     cd04273"
                     /db_xref="CDD:239801"
     Site            order(372..373,376,382)
                     /site_type="active"
                     /db_xref="CDD:239801"
     Region          449..513
                     /region_name="ADAM_CR_2"
                     /note="ADAM cysteine-rich domain; pfam17771"
                     /db_xref="CDD:436031"
     Region          526..578
                     /region_name="TSP1"
                     /note="Thrombospondin type 1 repeats; smart00209"
                     /db_xref="CDD:214559"
     Region          584..682
                     /region_name="ADAM_CR_3"
                     /note="ADAM cysteine-rich domain; pfam19236"
                     /db_xref="CDD:437068"
     Region          684..793
                     /region_name="ADAM_spacer1"
                     /note="ADAM-TS Spacer 1; pfam05986"
                     /db_xref="CDD:428708"
     Region          808..862
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:408800"
     Region          866..922
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:408800"
     Region          <1023..1361
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          1344..1392
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:408800"
     Region          1395..1450
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:408800"
     Region          1453..1499
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:408800"
     Region          1502..1557
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:408800"
     CDS             1..1615
                     /gene="Adamts7"
                     /gene_synonym="ADAM-TS7; ADAMTS7B"
                     /coded_by="NM_001003911.2:268..5115"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS40724.1"
                     /db_xref="GeneID:108153"
                     /db_xref="MGI:MGI:1347346"
ORIGIN      
        1 mhrgpsllli lcalasrvlg pasglvtegr agldivhpvr vdaggsflsy elwprvlrkr
       61 dvsttqassa fyqlqyqgre llfnlttnpy lmapgfvsei rrhstlghah iqtsvptchl
      121 lgdvqdpele ggfaaisacd glrgvfqlsn edyfiepldg vsaqpghaqp hvvykhqgsr
      181 kqaqqgdsrp sgtcgmqvpp dleqqrehwe qqqqkrrqqr svskekwvet lvvadskmve
      241 yhgqpqvesy vltimnmvag lfhdpsignp ihisivrlii ledeekdlki thhaeetlkn
      301 fcrwqknini kgddhpqhhd tailltrkdl casmnqpcet lglshvsglc hpqlscsvse
      361 dtgmplaftv ahelghsfgi qhdgtgndce sigkrpfims pqllydrgip ltwsrcsrey
      421 itrfldrgwg lclddrpskd vialpsvlpg vlydvnhqcr lqygshsayc edmddvchtl
      481 wcsvgttchs kldaavdgts cgknkwclkg ecvpegfqpe avdggwsgws awsdcsrscg
      541 vgvrsserqc tqpvpknrgk ycvgerkrsq lcnlpacppd rpsfrhtqcs qfdgmlykgk
      601 lhkwvpvpnd dnpcelhcrp snssnteklr davvdgtpcy qsrisrdicl ngicknvgcd
      661 fvidsgaeed rcgvcrgdgs tcqtvsrtfk etegqgyvdi glipagarei lieevaeaan
      721 flalrsedpd kyflnggwti qwngdyrvag ttftyarkgn wenltspgpt sepvwiqllf
      781 qeknpgvhyq ytiqrdshdq vrppefswhy gpwskctvtc gtgvqrqsly cmerqagvva
      841 eeycntlnrp derqrkcsee pcpprwwage wqpcsrscgp eglsrravfc irsmgldeqr
      901 alelsacehl prplaetpcn rhvicpstwg vgnwsqypmy ivdtgasgsg ssspelfnev
      961 dfipnqlapr pspasspkpv sisnaideee ldppgpvfvd dfyydynfin fhedlsygsf
     1021 eephpdlvdn ggwtapphir ptespsdtpv ptagalgaea ediqgswsps pllseasysp
     1081 pgleqtsinp lanflteedt pmgapelgfp slpwppasvd dmmtpvgpgn pdellvkede
     1141 qsppstpwsd rnklstdgnp lghtspalpq spiptqpspp sisptqasps pdvvevstgw
     1201 naawdpvlea dlkpghgelp stvevasppl lpmatvpgiw grdsplepgt ptfsspelss
     1261 qhlktltmpg tllltvptdl rspgpsgqpq tpnlegtqsp gllptparet qtnsskdpev
     1321 qplqpsleed gdpadplpar naswqvgnws qcsttcglga iwrlvscssg ndedctlasr
     1381 pqparhchlr pcaawrtgnw skcsrncggg sstrdvqcvd trdlrplrpf hcqpgptkpp
     1441 nrqlcgtqpc lpwytsswre cseacgggeq qrlvtcpepg lceeslrpnn srpcnthpct
     1501 qwvvgpwgqc sapcgggvqr rlvrcvntqt glaeedsdlc sheawpessr pcatedcelv
     1561 epprcerdrl sfnfcetlrl lgrcqlptir aqccrscppl srgvpsrghq rvarr
//
LOCUS       NP_001104572             574 aa            linear   ROD 09-OCT-2023
DEFINITION  prelamin-A/C isoform C [Mus musculus].
ACCESSION   NP_001104572
VERSION     NP_001104572.1
DBSOURCE    REFSEQ: accession NM_001111102.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 574)
  AUTHORS   Kim JR, Kim PH, Presnell A, Tu Y and Young SG.
  TITLE     Revisiting the truncated lamin A produced by a commonly used strain
            of Lmna knockout mice
  JOURNAL   Nucleus 14 (1), 2262308 (2023)
   PUBMED   37754663
  REMARK    GeneRIF: Revisiting the truncated lamin A produced by a commonly
            used strain of Lmna knockout mice.
REFERENCE   2  (residues 1 to 574)
  AUTHORS   Chang L, Huang R, Chen J, Li G, Shi G, Xu B and Wang L.
  TITLE     An alpha-helix variant p.Arg156Pro in LMNA as a cause of hereditary
            dilated cardiomyopathy: genetics and bioinfomatics exploration
  JOURNAL   BMC Med Genomics 16 (1), 229 (2023)
   PUBMED   37784143
  REMARK    GeneRIF: An alpha-helix variant p.Arg156Pro in LMNA as a cause of
            hereditary dilated cardiomyopathy: genetics and bioinfomatics
            exploration.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 574)
  AUTHORS   Pruvost M, Patzig J, Yattah C, Selcen I, Hernandez M, Park HJ,
            Moyon S, Liu S, Morioka MS, Shopland L, Al-Dalahmah O, Bendl J,
            Fullard JF, Roussos P, Goldman J, He Y, Dupree JL and Casaccia P.
  TITLE     The stability of the myelinating oligodendrocyte transcriptome is
            regulated by the nuclear lamina
  JOURNAL   Cell Rep 42 (8), 112848 (2023)
   PUBMED   37515770
REFERENCE   4  (residues 1 to 574)
  AUTHORS   Jahn D, Schramm S, Benavente R and Alsheimer M.
  TITLE     Dynamic properties of meiosis-specific lamin C2 and its impact on
            nuclear envelope integrity
  JOURNAL   Nucleus 1 (3), 273-283 (2010)
   PUBMED   21327075
  REMARK    GeneRIF: lamin C2 as a 'natural lamin deletion mutant' that confers
            unique properties to the nuclear envelope which would be essential
            for dynamic telomere repositioning during meiotic prophase I
REFERENCE   5  (residues 1 to 574)
  AUTHORS   Sullivan T, Escalante-Alcalde D, Bhatt H, Anver M, Bhat N,
            Nagashima K, Stewart CL and Burke B.
  TITLE     Loss of A-type lamin expression compromises nuclear envelope
            integrity leading to muscular dystrophy
  JOURNAL   J Cell Biol 147 (5), 913-920 (1999)
   PUBMED   10579712
REFERENCE   6  (residues 1 to 574)
  AUTHORS   Eggert M, Radomski N, Tripier D, Traub P and Jost E.
  TITLE     Identification of phosphorylation sites on murine nuclear lamin C
            by RP-HPLC and microsequencing
  JOURNAL   FEBS Lett 292 (1-2), 205-209 (1991)
   PUBMED   1959608
REFERENCE   7  (residues 1 to 574)
  AUTHORS   Weber K, Plessmann U and Traub P.
  TITLE     Maturation of nuclear lamin A involves a specific carboxy-terminal
            trimming, which removes the polyisoprenylation site from the
            precursor; implications for the structure of the nuclear lamina
  JOURNAL   FEBS Lett 257 (2), 411-414 (1989)
   PUBMED   2583287
REFERENCE   8  (residues 1 to 574)
  AUTHORS   Riedel W and Werner D.
  TITLE     Nucleotide sequence of the full-length mouse lamin C cDNA and its
            deduced amino-acid sequence
  JOURNAL   Biochim Biophys Acta 1008 (1), 119-122 (1989)
   PUBMED   2719959
REFERENCE   9  (residues 1 to 574)
  AUTHORS   Rober RA, Weber K and Osborn M.
  TITLE     Differential timing of nuclear lamin A/C expression in the various
            organs of the mouse embryo and the young animal: a developmental
            study
  JOURNAL   Development 105 (2), 365-378 (1989)
   PUBMED   2680424
REFERENCE   10 (residues 1 to 574)
  AUTHORS   Houliston E, Guilly MN, Courvalin JC and Maro B.
  TITLE     Expression of nuclear lamins during mouse preimplantation
            development
  JOURNAL   Development 102 (2), 271-278 (1988)
   PUBMED   3046911
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC145168.5, AK149998.1 and
            AK210245.1.
            
            Summary: This gene encodes a protein that is a member of the lamin
            family. Nuclear lamins, intermediate filament-like proteins, are
            the major components of the nuclear lamina, a protein meshwork
            associated with the inner nuclear membrane. This meshwork is
            thought to maintain the integrity of the nuclear envelope,
            participate in chromatin organization, and regulate gene
            transcription. Vertebrate lamins consist of two types, A and B.
            This protein is an A-type and is proposed to be developmentally
            regulated. In mouse deficiency of this gene is associated with
            muscular dystrophy. Mouse lines with different mutations in this
            gene serve as pathophysiological models for several human
            laminopathies. In humans, mutations in this gene lead to several
            diseases: Emery-Dreifuss muscular dystrophy, familial partial
            lipodystrophy, limb girdle muscular dystrophy, dilated
            cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford
            progeria syndrome. Alternative splicing results in multiple
            transcript variants that encode different protein isoforms.
            [provided by RefSeq, May 2013].
            
            Transcript Variant: This variant (3) lacks several 3' exons but
            contains an alternate 3' structure, and thus differs in the 3'
            coding region and 3' UTR, compared to variant 1. The encoded
            isoform (C) has a distinct and shorter C-terminus, compared to
            isoform A.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK149998.1, AK152846.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..574
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 38.84 cM"
     Protein         1..574
                     /product="prelamin-A/C isoform C"
                     /note="prelamin-A/C; lamin-A/C; lamin C"
                     /calculated_mol_wt=65315
     Region          1..130
                     /region_name="Interaction with MLIP.
                     /evidence=ECO:0000250|UniProtKB:P02545"
                     /note="propagated from UniProtKB/Swiss-Prot (P48678.2)"
     Region          1..33
                     /region_name="Head"
                     /note="propagated from UniProtKB/Swiss-Prot (P48678.2)"
     Region          1..25
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P48678.2)"
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            3
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            12
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            18
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            19
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            22
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:19144319, ECO:0007744|PubMed:21183079;
                     propagated from UniProtKB/Swiss-Prot (P48678.2)"
     Region          30..386
                     /region_name="Filament"
                     /note="Intermediate filament protein; pfam00038"
                     /db_xref="CDD:425436"
     Site            32
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Region          34..70
                     /region_name="Coil 1A"
                     /note="propagated from UniProtKB/Swiss-Prot (P48678.2)"
     Site            51
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            66
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Region          71..80
                     /region_name="Linker 1"
                     /note="propagated from UniProtKB/Swiss-Prot (P48678.2)"
     Site            71
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Region          81..218
                     /region_name="Coil 1B"
                     /note="propagated from UniProtKB/Swiss-Prot (P48678.2)"
     Site            107
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            108
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            123
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            135
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            155
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            171
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            201
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            212
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Region          219..242
                     /region_name="Linker 2"
                     /note="propagated from UniProtKB/Swiss-Prot (P48678.2)"
     Region          243..383
                     /region_name="Coil 2"
                     /note="propagated from UniProtKB/Swiss-Prot (P48678.2)"
     Site            260
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            266
                     /site_type="other"
                     /note="Heptad change of phase; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            270
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            277
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            301
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            307
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            311
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            325
                     /site_type="other"
                     /note="Stutter. /evidence=ECO:0000305; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            330
                     /site_type="other"
                     /note="Heptad change of phase; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Region          384..442
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P48678.2)"
     Site            390
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19131326,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            392
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:1959608; Phosphoserine, by
                     CDK1. /evidence=ECO:0000269|PubMed:1959608,
                     ECO:0007744|PubMed:19131326, ECO:0007744|PubMed:21183079;
                     propagated from UniProtKB/Swiss-Prot (P48678.2)"
     Site            395
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            398
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            403
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            404
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            407
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:1959608; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            409
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:1959608; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            414
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Region          417..422
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (P48678.2)"
     Site            429
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            431
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Region          434..541
                     /region_name="LTD"
                     /note="Lamin Tail Domain; pfam00932"
                     /db_xref="CDD:425951"
     Site            450
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            457
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            458
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            460
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            463
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            496
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P48679; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            500
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P48679; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            505
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            510
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P48679; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            533
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            546
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19144319; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            548
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            569
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            570
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     CDS             1..574
                     /gene="Lmna"
                     /gene_synonym="Dhe"
                     /coded_by="NM_001111102.2:250..1974"
                     /note="isoform C is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS50951.1"
                     /db_xref="GeneID:16905"
                     /db_xref="MGI:MGI:96794"
ORIGIN      
        1 metpsqrrat rsgaqasstp lsptritrlq ekedlqelnd rlavyidrvr sletenaglr
       61 lriteseevv srevsgikaa yeaelgdark tldsvakera rlqlelskvr eefkelkarn
      121 tkkegdllaa qarlkdleal lnskeaalst alsekrtleg elhdlrgqva kleaalgeak
      181 kqlqdemlrr vdaenrlqtl keeldfqkni yseelretkr rhetrlveid ngkqrefesr
      241 ladalqelra qhedqveqyk kelektysak ldnarqsaer nsnlvgaahe elqqsririd
      301 slsaqlsqlq kqlaakeakl rdledslare rdtsrrllae keremaemra rmqqqldeyq
      361 elldiklald meihayrkll egeeerlrls psptsqrsrg rasshssqsq gggsvtkkrk
      421 lessesrssf sqhartsgrv aveevdeegk fvrlrnksne dqsmgnwqir rqngddplmt
      481 yrfppkftlk agqvvtiwas gagathsppt dlvwkaqntw gcgsslrtal instgeevam
      541 rklvrsltmv ednedddedg eellhhhrvs gsrr
//
LOCUS       NP_032052                452 aa            linear   ROD 09-OCT-2023
DEFINITION  Friend leukemia integration 1 transcription factor isoform 1 [Mus
            musculus].
ACCESSION   NP_032052
VERSION     NP_032052.1
DBSOURCE    REFSEQ: accession NM_008026.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 452)
  AUTHORS   Wang X, Richard ML, Caldwell TS, Sundararaj K, Sato S, Nowling TK
            and Zhang XK.
  TITLE     Role of the transcription factor Fli-1 on the CXCL10/CXCR3 Axis
  JOURNAL   Front Immunol 14, 1219279 (2023)
   PUBMED   37790939
  REMARK    GeneRIF: Role of the transcription factor Fli-1 on the CXCL10/CXCR3
            Axis.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 452)
  AUTHORS   Sato S, Zhang XK, Matsuoka N, Sumichika Y, Saito K, Yoshida S,
            Matsumoto H, Temmoku J, Fujita Y, Asano T and Migita K.
  TITLE     Transcription factor Fli-1 impacts the expression of CXCL13 and
            regulates immune cell infiltration into the kidney in MRL/lpr mouse
  JOURNAL   Lupus Sci Med 10 (1) (2023)
   PUBMED   37094946
  REMARK    GeneRIF: Transcription factor Fli-1 impacts the expression of
            CXCL13 and regulates immune cell infiltration into the kidney in
            MRL/lpr mouse.
REFERENCE   3  (residues 1 to 452)
  AUTHORS   Shintani A, Fukai S, Nobusawa R, Taniguchi K, Hatatani T, Nagai H,
            Sakai T, Yoshimura T, Miyasaka M and Hayasaka H.
  TITLE     Dach1 transcription factor regulates the expression of peripheral
            node addressin and lymphocyte trafficking in lymph nodes
  JOURNAL   Curr Res Immunol 3, 175-185 (2022)
   PUBMED   36045707
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 452)
  AUTHORS   Sinha T, Lammerts van Bueren K, Dickel DE, Zlatanova I, Thomas R,
            Lizama CO, Xu SM, Zovein AC, Ikegami K, Moskowitz IP, Pollard KS,
            Pennacchio LA and Black BL.
  TITLE     Differential Etv2 threshold requirement for endothelial and
            erythropoietic development
  JOURNAL   Cell Rep 39 (9), 110881 (2022)
   PUBMED   35649376
REFERENCE   5  (residues 1 to 452)
  AUTHORS   Sarrazin S, Starck J, Gonnet C, Doubeikovski A, Melet F and Morle
            F.
  TITLE     Negative and translation termination-dependent positive control of
            FLI-1 protein synthesis by conserved overlapping 5' upstream open
            reading frames in Fli-1 mRNA
  JOURNAL   Mol Cell Biol 20 (9), 2959-2969 (2000)
   PUBMED   10757781
REFERENCE   6  (residues 1 to 452)
  AUTHORS   Barbeau B, Bergeron D, Beaulieu M, Nadjem Z and Rassart E.
  TITLE     Characterization of the human and mouse Fli-1 promoter regions
  JOURNAL   Biochim Biophys Acta 1307 (2), 220-232 (1996)
   PUBMED   8679708
REFERENCE   7  (residues 1 to 452)
  AUTHORS   Watson DK, Smyth FE, Thompson DM, Cheng JQ, Testa JR, Papas TS and
            Seth A.
  TITLE     The ERGB/Fli-1 gene: isolation and characterization of a new member
            of the family of human ETS transcription factors
  JOURNAL   Cell Growth Differ 3 (10), 705-713 (1992)
   PUBMED   1445800
REFERENCE   8  (residues 1 to 452)
  AUTHORS   Delattre O, Zucman J, Plougastel B, Desmaze C, Melot T, Peter M,
            Kovar H, Joubert I, de Jong P, Rouleau G et al.
  TITLE     Gene fusion with an ETS DNA-binding domain caused by chromosome
            translocation in human tumours
  JOURNAL   Nature 359 (6391), 162-165 (1992)
   PUBMED   1522903
REFERENCE   9  (residues 1 to 452)
  AUTHORS   Moore SK, Appella E, Villar CJ and Kozak CA.
  TITLE     Mapping of the mouse 86-kDa heat-shock protein expressed gene
            (Hsp86-1) on chromosome 12 and related genes on chromosomes 3, 4,
            9, and 11
  JOURNAL   Genomics 10 (4), 1019-1029 (1991)
   PUBMED   1916807
REFERENCE   10 (residues 1 to 452)
  AUTHORS   Bergeron D, Poliquin L, Kozak CA and Rassart E.
  TITLE     Identification of a common viral integration region in Cas-Br-E
            murine leukemia virus-induced non-T-, non-B-cell lymphomas
  JOURNAL   J Virol 65 (1), 7-15 (1991)
   PUBMED   1845910
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127581.4 and AC141646.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036655.1, AK154714.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            regulatory uORF        :: PMID: 10757781
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..452
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 17.74 cM"
     Protein         1..452
                     /product="Friend leukemia integration 1 transcription
                     factor isoform 1"
                     /note="friend leukemia integration 1 transcription factor;
                     retroviral integration site protein Fli-1"
                     /calculated_mol_wt=50871
     Site            39
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P26323.1)"
     Region          114..204
                     /region_name="SAM_PNT-FLI-1"
                     /note="Sterile alpha motif (SAM)/Pointed domain of friend
                     leukemia integration 1 transcription activator; cd08541"
                     /db_xref="CDD:188883"
     Region          236..260
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P26323.1)"
     Region          280..363
                     /region_name="ETS"
                     /note="erythroblast transformation specific domain;
                     smart00413"
                     /db_xref="CDD:197710"
     CDS             1..452
                     /gene="Fli1"
                     /gene_synonym="EWSR2; Fli-1; SIC-1; Sic1"
                     /coded_by="NM_008026.6:190..1548"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS40571.1"
                     /db_xref="GeneID:14247"
                     /db_xref="MGI:MGI:95554"
ORIGIN      
        1 mdgtikeals vvsddqslfd saygaaahlp kadmtasgsp dygqphkinp lppqqewinq
       61 pvrvnvkrey dhmngsresp vdcsvskcnk lvgggeanpm nynsymdekn gppppnmttn
      121 errvivpadp tlwtqehvrq wlewaikeyg lmeidtsffq nmdgkelckm nkedflrats
      181 ayntevllsh lsylressll aynttshtdq ssrlnvkedp sydsvrrgaw nnnmnsglnk
      241 spllggsqtm gknteqrpqp dpyqilgpts srlanpgsgq iqlwqfllel lsdsanasci
      301 twegtngefk mtdpdevarr wgerkskpnm nydklsralr yyydknimtk vhgkryaykf
      361 dfhgiaqalq phptetsmyk ypsdisymps yhahqqkvnf vpshpssmpv tsssffgaas
      421 qywtsptagi ypnpsvprhp nthvpshlgs yy
//
LOCUS       NP_001259027              73 aa            linear   ROD 09-OCT-2023
DEFINITION  uncharacterized protein LOC16592 isoform 3 [Mus musculus].
ACCESSION   NP_001259027
VERSION     NP_001259027.1
DBSOURCE    REFSEQ: accession NM_001272098.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 73)
  AUTHORS   Penman SL, Roeder NM, Berthold EC, Senetra AS, Marion M, Richardson
            BJ, White O, Fearby NL, McCurdy CR, Hamilton J, Sharma A and Thanos
            PK.
  TITLE     FABP5 is important for cognitive function and is an important
            regulator of the physiological effects and pharmacokinetics of
            acute Delta9 tetrahydrocannabinol inhalation in mice
  JOURNAL   Pharmacol Biochem Behav 231, 173633 (2023)
   PUBMED   37716413
  REMARK    GeneRIF: FABP5 is important for cognitive function and is an
            important regulator of the physiological effects and
            pharmacokinetics of acute Delta9 tetrahydrocannabinol inhalation in
            mice.
REFERENCE   2  (residues 1 to 73)
  AUTHORS   Chen Z, He C, Gao Z, Li Y, He Q, Wang Y and Cai C.
  TITLE     Polypyrimidine tract binding protein 1 exacerbates cardiac fibrosis
            by regulating fatty acid-binding protein 5
  JOURNAL   ESC Heart Fail 10 (3), 1677-1688 (2023)
   PUBMED   36788730
  REMARK    GeneRIF: Polypyrimidine tract binding protein 1 exacerbates cardiac
            fibrosis by regulating fatty acid-binding protein 5.
REFERENCE   3  (residues 1 to 73)
  AUTHORS   Guo Q, Kawahata I, Cheng A, Wang H, Jia W, Yoshino H and Fukunaga
            K.
  TITLE     Fatty acid-binding proteins 3 and 5 are involved in the initiation
            of mitochondrial damage in ischemic neurons
  JOURNAL   Redox Biol 59, 102547 (2023)
   PUBMED   36481733
  REMARK    GeneRIF: Fatty acid-binding proteins 3 and 5 are involved in the
            initiation of mitochondrial damage in ischemic neurons.
REFERENCE   4  (residues 1 to 73)
  AUTHORS   Reynolds JM, Liu Q, Brittingham KC, Liu Y, Gruenthal M, Gorgun CZ,
            Hotamisligil GS, Stout RD and Suttles J.
  TITLE     Deficiency of fatty acid-binding proteins in mice confers
            protection from development of experimental autoimmune
            encephalomyelitis
  JOURNAL   J Immunol 179 (1), 313-321 (2007)
   PUBMED   17579051
  REMARK    GeneRIF: Metabolic-inflammatory pathway cross-regulation by
            epidermal-type FABP contributes to adaptive immune responses and
            subsequent autoimmune inflammation.
REFERENCE   5  (residues 1 to 73)
  AUTHORS   Maeda K, Cao H, Kono K, Gorgun CZ, Furuhashi M, Uysal KT, Cao Q,
            Atsumi G, Malone H, Krishnan B, Minokoshi Y, Kahn BB, Parker RA and
            Hotamisligil GS.
  TITLE     Adipocyte/macrophage fatty acid binding proteins control integrated
            metabolic responses in obesity and diabetes
  JOURNAL   Cell Metab 1 (2), 107-119 (2005)
   PUBMED   16054052
REFERENCE   6  (residues 1 to 73)
  AUTHORS   Owada Y, Suzuki R, Iwasa H, Spener F and Kondo H.
  TITLE     Localization of epidermal-type fatty acid binding protein in the
            thymic epithelial cells of mice
  JOURNAL   Histochem Cell Biol 117 (1), 55-60 (2002)
   PUBMED   11819097
REFERENCE   7  (residues 1 to 73)
  AUTHORS   Yanase H, Shimizu H, Kanda T, Fujii H and Iwanaga T.
  TITLE     Cellular localization of the diazepam binding inhibitor (DBI) in
            the gastrointestinal tract of mice and its coexistence with the
            fatty acid binding protein (FABP)
  JOURNAL   Arch Histol Cytol 64 (4), 449-460 (2001)
   PUBMED   11757913
REFERENCE   8  (residues 1 to 73)
  AUTHORS   Hertzel AV and Bernlohr DA.
  TITLE     Cloning and chromosomal location of the murine keratinocyte
            lipid-binding protein gene
  JOURNAL   Gene 221 (2), 235-243 (1998)
   PUBMED   9795232
REFERENCE   9  (residues 1 to 73)
  AUTHORS   Bleck B, Hohoff C, Binas B, Rustow B, Dixkens C, Hameister H,
            Borchers T and Spener F.
  TITLE     Cloning and chromosomal localisation of the murine epidermal-type
            fatty acid binding protein gene (Fabpe)
  JOURNAL   Gene 215 (1), 123-130 (1998)
   PUBMED   9666100
REFERENCE   10 (residues 1 to 73)
  AUTHORS   Krieg P, Feil S, Furstenberger G and Bowden GT.
  TITLE     Tumor-specific overexpression of a novel keratinocyte lipid-binding
            protein. Identification and characterization of a cloned sequence
            activated during multistage carcinogenesis in mouse skin
  JOURNAL   J Biol Chem 268 (23), 17362-17369 (1993)
   PUBMED   8349619
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC157379.7, W54445.1 and
            BE987062.1.
            
            Summary: The protein encoded by this gene is part of the fatty acid
            binding protein family (FABP). FABPs are a family of small, highly
            conserved, cytoplasmic proteins that bind long-chain fatty acids
            and other hydrophobic ligands and participate in fatty acid uptake,
            transport, and metabolism. In humans this gene has been associated
            with psoriasis and type 2 diabetes. In mouse deficiency of this
            gene in combination with a deficiency in Fabp4 confers protection
            against atherosclerosis, diet-induced obesity, insulin resistance
            and experimental autoimmune encephalomyelitis (the mouse model for
            multiple sclerosis). Alternative splicing results in multiple
            transcript variants that encode different protein isoforms. The
            mouse genome contains many pseudogenes similar to this locus.
            [provided by RefSeq, Jan 2013].
            
            Transcript Variant: This variant (3) lacks an exon in the coding
            region, which results in a frameshift, compared to variant 1.
            Variant 3 lacks a large portion of the central coding region found
            in variant 1. The encoded isoform (3) is shorter and has a distinct
            C-terminus, compared to isoform 1. This isoform lacks the lipocalin
            domain found in isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: W54445.1, SRR7345562.4455647.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..73
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 2.47 cM"
     Protein         1..73
                     /product="uncharacterized protein LOC16592 isoform 3"
                     /note="fatty acid-binding protein, epidermal; epithelial
                     fatty acid-binding protein; keratinocyte lipid-binding
                     protein; epidermal-type fatty acid-binding protein;
                     psoriasis-associated fatty acid-binding protein homolog"
                     /calculated_mol_wt=8239
     Region          6..>26
                     /region_name="lipocalin_FABP"
                     /note="lipocalin/cytosolic fatty acid-binding protein
                     family; cl10502"
                     /db_xref="CDD:447910"
     CDS             1..73
                     /gene="Fabp5"
                     /gene_synonym="E-FABP; Fabpe; Klbp; mal1; PA-FABP"
                     /coded_by="NM_001272098.1:56..277"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="GeneID:16592"
                     /db_xref="MGI:MGI:101790"
ORIGIN      
        1 maslkdlegk wrlmeshgfe eymkeldglh lprrcpgpap amgregehdn kktegweddr
       61 gvcheqchlh sgl
//
LOCUS       NP_032863                416 aa            linear   ROD 09-OCT-2023
DEFINITION  PRKCA-binding protein [Mus musculus].
ACCESSION   NP_032863
VERSION     NP_032863.2
DBSOURCE    REFSEQ: accession NM_008837.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 416)
  AUTHORS   Birmingham EA, Wickens MM, Kirkland JM, Knouse MC, McGrath AG and
            Briand LA.
  TITLE     Circulating ovarian hormones interact with protein interacting with
            C kinase (PICK1) within the medial prefrontal cortex to influence
            cocaine seeking in female mice
  JOURNAL   Horm Behav 155, 105408 (2023)
   PUBMED   37541099
  REMARK    GeneRIF: Circulating ovarian hormones interact with protein
            interacting with C kinase (PICK1) within the medial prefrontal
            cortex to influence cocaine seeking in female mice.
REFERENCE   2  (residues 1 to 416)
  AUTHORS   Ramsakha N, Ojha P, Pal S, Routh S, Citri A and Bhattacharyya S.
  TITLE     A vital role for PICK1 in the differential regulation of
            metabotropic glutamate receptor internalization and synaptic AMPA
            receptor endocytosis
  JOURNAL   J Biol Chem 299 (6), 104837 (2023)
   PUBMED   37209824
  REMARK    GeneRIF: A vital role for PICK1 in the differential regulation of
            metabotropic glutamate receptor internalization and synaptic AMPA
            receptor endocytosis.
REFERENCE   3  (residues 1 to 416)
  AUTHORS   Du YQ, Shu CY, Zheng M, Xu WD, Sun Y, Shen L, Zhang C, Zhang YX,
            Wang QN, Li KQ, Chen BY, Hao K, Lyu JX and Wang Z.
  TITLE     Truncating PICK1 Variant Identified in Azoospermia Affected
            Mitochondrial Dysfunction in Knockout Mice
  JOURNAL   Curr Med Sci 43 (2), 313-323 (2023)
   PUBMED   36971977
  REMARK    GeneRIF: Truncating PICK1 Variant Identified in Azoospermia
            Affected Mitochondrial Dysfunction in Knockout Mice.
REFERENCE   4  (residues 1 to 416)
  AUTHORS   Zhu Z, Wang W, Gu C, Wang M and Yan Y.
  TITLE     The M1 muscarinic acetylcholine receptor regulates the surface
            expression of the AMPA receptor subunit GluA2 via PICK1
  JOURNAL   Psychopharmacology (Berl) 240 (1), 239-248 (2023)
   PUBMED   36564670
  REMARK    GeneRIF: The M1 muscarinic acetylcholine receptor regulates the
            surface expression of the AMPA receptor subunit GluA2 via PICK1.
REFERENCE   5  (residues 1 to 416)
  AUTHORS   Longatti A, Ponzoni L, Moretto E, Giansante G, Lattuada N, Colombo
            MN, Francolini M, Sala M, Murru L and Passafaro M.
  TITLE     Arhgap22 Disruption Leads to RAC1 Hyperactivity Affecting
            Hippocampal Glutamatergic Synapses and Cognition in Mice
  JOURNAL   Mol Neurobiol 58 (12), 6092-6110 (2021)
   PUBMED   34455539
REFERENCE   6  (residues 1 to 416)
  AUTHORS   Takeya R, Takeshige K and Sumimoto H.
  TITLE     Interaction of the PDZ domain of human PICK1 with class I
            ADP-ribosylation factors
  JOURNAL   Biochem Biophys Res Commun 267 (1), 149-155 (2000)
   PUBMED   10623590
REFERENCE   7  (residues 1 to 416)
  AUTHORS   Dev KK, Nishimune A, Henley JM and Nakanishi S.
  TITLE     The protein kinase C alpha binding protein PICK1 interacts with
            short but not long form alternative splice variants of AMPA
            receptor subunits
  JOURNAL   Neuropharmacology 38 (5), 635-644 (1999)
   PUBMED   10340301
REFERENCE   8  (residues 1 to 416)
  AUTHORS   Torres R, Firestein BL, Dong H, Staudinger J, Olson EN, Huganir RL,
            Bredt DS, Gale NW and Yancopoulos GD.
  TITLE     PDZ proteins bind, cluster, and synaptically colocalize with Eph
            receptors and their ephrin ligands
  JOURNAL   Neuron 21 (6), 1453-1463 (1998)
   PUBMED   9883737
REFERENCE   9  (residues 1 to 416)
  AUTHORS   Staudinger J, Lu J and Olson EN.
  TITLE     Specific interaction of the PDZ domain protein PICK1 with the COOH
            terminus of protein kinase C-alpha
  JOURNAL   J Biol Chem 272 (51), 32019-32024 (1997)
   PUBMED   9405395
REFERENCE   10 (residues 1 to 416)
  AUTHORS   Staudinger J, Zhou J, Burgess R, Elledge SJ and Olson EN.
  TITLE     PICK1: a perinuclear binding protein and substrate for protein
            kinase C isolated by the yeast two-hybrid system
  JOURNAL   J Cell Biol 128 (3), 263-271 (1995)
   PUBMED   7844141
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591921.6, BU698586.1, AK090155.1, AI893973.1 and AI385692.1.
            
            On Sep 2, 2006 this sequence version replaced NP_032863.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.2754765.1,
                                           SRR7652917.769742.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..416
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 37.7 cM"
     Protein         1..416
                     /product="PRKCA-binding protein"
                     /note="protein kinase C-alpha-binding protein; protein
                     that interacts with C kinase 1"
                     /calculated_mol_wt=46396
     Region          19..99
                     /region_name="PDZ"
                     /note="Domain present in PSD-95, Dlg, and ZO-1/2;
                     smart00228"
                     /db_xref="CDD:214570"
     Site            order(32..35,37,86..87,90..91)
                     /site_type="other"
                     /note="protein binding site [polypeptide binding]"
                     /db_xref="CDD:238492"
     Site            82
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9NRD5; propagated from
                     UniProtKB/Swiss-Prot (Q62083.2)"
     Region          146..360
                     /region_name="BAR_PICK1"
                     /note="The Bin/Amphiphysin/Rvs (BAR) domain of Protein
                     Interacting with C Kinase 1; cd07659"
                     /db_xref="CDD:153343"
     Site            order(162..163,169,173,176,179..180,183,186..187,191,
                     193..194,197,200..201,206..207,209..210,213,217,326,
                     330..331,334..335,337..338,345..346,348..349)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:153343"
     Site            order(168,171,174..175,178..179,181..183,185..186,222,225,
                     229,232..233)
                     /site_type="active"
                     /note="putative Rac binding site [active]"
                     /db_xref="CDD:153343"
     Region          373..416
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62083.2)"
     CDS             1..416
                     /gene="Pick1"
                     /gene_synonym="Prkcabp"
                     /coded_by="NM_008837.3:312..1562"
                     /db_xref="CCDS:CCDS27635.1"
                     /db_xref="GeneID:18693"
                     /db_xref="MGI:MGI:894645"
ORIGIN      
        1 mfadldydie edklgiptvp gkvtlqkdaq nligisiggg aqycpclyiv qvfdntpaal
       61 dgtvaagdei tgvngksikg ktkvevakmi qevkgevtih ynklqadpkq gmsldivlkk
      121 vkhrlvenms sgtadalgls railcndglv krleelerta elykgmteht knllrafyel
      181 sqthrafgdv fsvigvrepq paaseafvkf adahrsiekf girllktikp mltdlntyln
      241 kaipdtrlti kkyldvkfey lsyclkvkem ddeeyscial geplyrvstg nyeyrlilrc
      301 rqeararfsq mrkdvlekme lldqkhvqdi vfqlqrfvst mskyyndcya vlqdadvfpi
      361 evdlahttla ygpnqgsftd geeedeeeed gaarevskda cgatgptdkg gswcds
//
LOCUS       NP_032986                403 aa            linear   ROD 09-OCT-2023
DEFINITION  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and
            dual-specificity protein phosphatase PTEN [Mus musculus].
ACCESSION   NP_032986
VERSION     NP_032986.1
DBSOURCE    REFSEQ: accession NM_008960.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 403)
  AUTHORS   Brodaczewska K, Majewska A, Filipiak-Duliban A and Kieda C.
  TITLE     Pten knockout affects drug resistance differently in melanoma and
            kidney cancer
  JOURNAL   Pharmacol Rep 75 (5), 1187-1199 (2023)
   PUBMED   37673853
  REMARK    GeneRIF: Pten knockout affects drug resistance differently in
            melanoma and kidney cancer.
REFERENCE   2  (residues 1 to 403)
  AUTHORS   Baird L, Taguchi K, Zhang A, Takahashi Y, Suzuki T, Kensler TW and
            Yamamoto M.
  TITLE     A NRF2-induced secretory phenotype activates immune surveillance to
            remove irreparably damaged cells
  JOURNAL   Redox Biol 66, 102845 (2023)
   PUBMED   37597423
REFERENCE   3  (residues 1 to 403)
  AUTHORS   Doha ZO, Wang X, Calistri NL, Eng J, Daniel CJ, Ternes L, Kim EN,
            Pelz C, Munks M, Betts C, Kwon S, Bucher E, Li X, Waugh T, Tatarova
            Z, Blumberg D, Ko A, Kirchberger N, Pietenpol JA, Sanders ME,
            Langer EM, Dai MS, Mills G, Chin K, Chang YH, Coussens LM, Gray JW,
            Heiser LM and Sears RC.
  TITLE     MYC Deregulation and PTEN Loss Model Tumor and Stromal
            Heterogeneity of Aggressive Triple-Negative Breast Cancer
  JOURNAL   Nat Commun 14 (1), 5665 (2023)
   PUBMED   37704631
  REMARK    GeneRIF: MYC Deregulation and PTEN Loss Model Tumor and Stromal
            Heterogeneity of Aggressive Triple-Negative Breast Cancer.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 403)
  AUTHORS   Xu Z, He L, Wu Y, Yang L, Li C and Wu H.
  TITLE     PTEN regulates hematopoietic lineage plasticity via PU.1-dependent
            chromatin accessibility
  JOURNAL   Cell Rep 42 (8), 112967 (2023)
   PUBMED   37561626
  REMARK    GeneRIF: PTEN regulates hematopoietic lineage plasticity via
            PU.1-dependent chromatin accessibility.
REFERENCE   5  (residues 1 to 403)
  AUTHORS   Chessa TAM, Jung P, Anwar A, Suire S, Anderson KE, Barneda D,
            Kielkowska A, Sadiq BA, Lai IW, Felisbino S, Turnham DJ, Pearson
            HB, Phillips WA, Sasaki J, Sasaki T, Oxley D, Spensberger D,
            Segonds-Pichon A, Wilson M, Walker S, Okkenhaug H, Cosulich S,
            Hawkins PT and Stephens LR.
  TITLE     PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null
            prostate
  JOURNAL   Mol Cell 83 (16), 2991-3009 (2023)
   PUBMED   37567175
  REMARK    GeneRIF: PLEKHS1 drives PI3Ks and remodels pathway homeostasis in
            PTEN-null prostate.
REFERENCE   6  (residues 1 to 403)
  AUTHORS   Suzuki A, de la Pompa JL, Stambolic V, Elia AJ, Sasaki T, del Barco
            Barrantes I, Ho A, Wakeham A, Itie A, Khoo W, Fukumoto M and Mak
            TW.
  TITLE     High cancer susceptibility and embryonic lethality associated with
            mutation of the PTEN tumor suppressor gene in mice
  JOURNAL   Curr Biol 8 (21), 1169-1178 (1998)
   PUBMED   9799734
REFERENCE   7  (residues 1 to 403)
  AUTHORS   Stambolic V, Suzuki A, de la Pompa JL, Brothers GM, Mirtsos C,
            Sasaki T, Ruland J, Penninger JM, Siderovski DP and Mak TW.
  TITLE     Negative regulation of PKB/Akt-dependent cell survival by the tumor
            suppressor PTEN
  JOURNAL   Cell 95 (1), 29-39 (1998)
   PUBMED   9778245
REFERENCE   8  (residues 1 to 403)
  AUTHORS   Di Cristofano A, Pesce B, Cordon-Cardo C and Pandolfi PP.
  TITLE     Pten is essential for embryonic development and tumour suppression
  JOURNAL   Nat Genet 19 (4), 348-355 (1998)
   PUBMED   9697695
REFERENCE   9  (residues 1 to 403)
  AUTHORS   Hansen GM and Justice MJ.
  TITLE     Pten, a candidate tumor suppressor gene, maps to mouse chromosome
            19
  JOURNAL   Mamm Genome 9 (1), 88-90 (1998)
   PUBMED   9434957
REFERENCE   10 (residues 1 to 403)
  AUTHORS   Steck PA, Pershouse MA, Jasser SA, Yung WK, Lin H, Ligon AH,
            Langford LA, Baumgard ML, Hattier T, Davis T, Frye C, Hu R,
            Swedlund B, Teng DH and Tavtigian SV.
  TITLE     Identification of a candidate tumour suppressor gene, MMAC1, at
            chromosome 10q23.3 that is mutated in multiple advanced cancers
  JOURNAL   Nat Genet 15 (4), 356-362 (1997)
   PUBMED   9090379
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U92437.1, AK138025.1,
            CK616227.1 and BU701098.1.
            
            Summary: This gene encodes a phosphatase with dual activity against
            phospholipids and proteins, and acts as a tumor-suppressor. The
            protein contains four structural domains, a PIP2-binding domain, a
            catalytic tensin-type phosphatase domain, a C2 tensin-type domain
            and a PDZ-binding domain. The protein belongs to the protein
            tyrosine phosphatase family. Deletion of this gene in mice
            contribute to tumorigenesis in multiple tissues. [provided by
            RefSeq, Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK076980.1, AK088717.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..403
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 28.14 cM"
     Protein         1..403
                     /product="phosphatidylinositol 3,4,5-trisphosphate
                     3-phosphatase and dual-specificity protein phosphatase
                     PTEN"
                     /EC_number="3.1.3.67"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="mutated in multiple advanced cancers 1;
                     mitochondrial PTENalpha; PTENepsilon"
                     /calculated_mol_wt=47021
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylthreonine.
                     /evidence=ECO:0000250|UniProtKB:P60484; propagated from
                     UniProtKB/Swiss-Prot (O08586.1)"
     Region          24..181
                     /region_name="PTP_PTEN"
                     /note="protein tyrosine phosphatase-like catalytic domain
                     of phosphatase and tensin homolog; cd14509"
                     /db_xref="CDD:350359"
     Region          188..349
                     /region_name="PTEN_C2"
                     /note="C2 domain of PTEN tumor-suppressor protein;
                     pfam10409"
                     /db_xref="CDD:431265"
     Site            294
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (O08586.1)"
     Site            319
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P60484; propagated from
                     UniProtKB/Swiss-Prot (O08586.1)"
     Site            321
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P60484; propagated from
                     UniProtKB/Swiss-Prot (O08586.1)"
     Site            336
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by FRK.
                     /evidence=ECO:0000250|UniProtKB:P60484; propagated from
                     UniProtKB/Swiss-Prot (O08586.1)"
     Region          338..348
                     /region_name="Required for interaction with NOP53.
                     /evidence=ECO:0000250|UniProtKB:P60484"
                     /note="propagated from UniProtKB/Swiss-Prot (O08586.1)"
     Region          352..403
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O08586.1)"
     Site            366
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by GSK3-beta and PLK3.
                     /evidence=ECO:0000269|PubMed:20940307; propagated from
                     UniProtKB/Swiss-Prot (O08586.1)"
     Site            370
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2 and PLK3.
                     /evidence=ECO:0000269|PubMed:20940307; propagated from
                     UniProtKB/Swiss-Prot (O08586.1)"
     Site            380
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by ROCK1.
                     /evidence=ECO:0000269|PubMed:20008297,
                     ECO:0000269|PubMed:33428810; propagated from
                     UniProtKB/Swiss-Prot (O08586.1)"
     Site            382
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by ROCK1.
                     /evidence=ECO:0000269|PubMed:20008297,
                     ECO:0000269|PubMed:33428810; propagated from
                     UniProtKB/Swiss-Prot (O08586.1)"
     Site            383
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by ROCK1.
                     /evidence=ECO:0000269|PubMed:20008297,
                     ECO:0000269|PubMed:33428810; propagated from
                     UniProtKB/Swiss-Prot (O08586.1)"
     Site            385
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (O08586.1)"
     Region          401..403
                     /region_name="PDZ domain-binding.
                     /evidence=ECO:0000305|PubMed:33428810"
                     /note="propagated from UniProtKB/Swiss-Prot (O08586.1)"
     Site            401
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P60484; propagated from
                     UniProtKB/Swiss-Prot (O08586.1)"
     CDS             1..403
                     /gene="Pten"
                     /gene_synonym="2310035O07Rik; A130070J02Rik;
                     B430203M17Rik; MMAC1; PTENbeta; TEP1"
                     /coded_by="NM_008960.2:869..2080"
                     /db_xref="CCDS:CCDS29753.1"
                     /db_xref="GeneID:19211"
                     /db_xref="MGI:MGI:109583"
ORIGIN      
        1 mtaiikeivs rnkrryqedg fdldltyiyp niiamgfpae rlegvyrnni ddvvrfldsk
       61 hknhykiynl caerhydtak fncrvaqypf edhnppqlel ikpfcedldq wlseddnhva
      121 aihckagkgr tgvmicayll hrgkflkaqe aldfygevrt rdkkgvtips qrryvyyysy
      181 llknhldyrp vallfhkmmf etipmfsggt cnpqfvvcql kvkiyssnsg ptrredkfmy
      241 fefpqplpvc gdikveffhk qnkmlkkdkm fhfwvntffi pgpeetsekv engslcdqei
      301 dsicsierad ndkeylvltl tkndldkank dkanryfspn fkvklyftkt veepsnpeas
      361 sstsvtpdvs dnepdhyrys dttdsdpene pfdedqhsqi tkv
//
LOCUS       NP_001277746             301 aa            linear   ROD 09-OCT-2023
DEFINITION  SPARC isoform 2 precursor [Mus musculus].
ACCESSION   NP_001277746 XP_006532730
VERSION     NP_001277746.1
DBSOURCE    REFSEQ: accession NM_001290817.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 301)
  AUTHORS   Ryu S, Spadaro O, Sidorov S, Lee AH, Caprio S, Morrison C, Smith
            SR, Ravussin E, Shchukina I, Artyomov MN, Youm YH and Dixit VD.
  TITLE     Reduction of SPARC protects mice against NLRP3 inflammasome
            activation and obesity
  JOURNAL   J Clin Invest 133 (19), e169173 (2023)
   PUBMED   37781916
  REMARK    GeneRIF: Reduction of SPARC protects mice against NLRP3
            inflammasome activation and obesity.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 301)
  AUTHORS   Pina JO, Raju R, Roth DM, Winchester EW, Chattaraj P, Kidwai F,
            Faucz FR, Iben J, Mitra A, Campbell K, Fridell G, Esnault C, Cotney
            JL, Dale RK and D'Souza RN.
  TITLE     Multimodal spatiotemporal transcriptomic resolution of embryonic
            palate osteogenesis
  JOURNAL   Nat Commun 14 (1), 5687 (2023)
   PUBMED   37709732
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 301)
  AUTHORS   Feldt J, Garriz A, Rodriguez Benavente MC, Woodward AM, Zoukhri D
            and Argueso P.
  TITLE     The Matricellular Protein SPARC Decreases in the Lacrimal Gland At
            Adulthood and During Inflammation
  JOURNAL   Invest Ophthalmol Vis Sci 63 (13), 8 (2022)
   PUBMED   36479944
  REMARK    GeneRIF: The Matricellular Protein SPARC Decreases in the Lacrimal
            Gland At Adulthood and During Inflammation.
REFERENCE   4  (residues 1 to 301)
  AUTHORS   Mathes S, Fahrner A, Luca E and Krutzfeldt J.
  TITLE     Growth hormone/IGF-I-dependent signaling restores decreased
            expression of the myokine SPARC in aged skeletal muscle
  JOURNAL   J Mol Med (Berl) 100 (11), 1647-1658 (2022)
   PUBMED   36178526
  REMARK    GeneRIF: Growth hormone/IGF-I-dependent signaling restores
            decreased expression of the myokine SPARC in aged skeletal muscle.
REFERENCE   5  (residues 1 to 301)
  AUTHORS   Ryu S, Sidorov S, Ravussin E, Artyomov M, Iwasaki A, Wang A and
            Dixit VD.
  TITLE     The matricellular protein SPARC induces inflammatory
            interferon-response in macrophages during aging
  JOURNAL   Immunity 55 (9), 1609-1626 (2022)
   PUBMED   35963236
REFERENCE   6  (residues 1 to 301)
  AUTHORS   Baron B, Poirier C, Simon-Chazottes D, Barnier C and Guenet JL.
  TITLE     A new strategy useful for rapid identification of microsatellites
            from DNA libraries with large size inserts
  JOURNAL   Nucleic Acids Res 20 (14), 3665-3669 (1992)
   PUBMED   1386425
REFERENCE   7  (residues 1 to 301)
  AUTHORS   Bloom ML, Lee BK, Birkenmeier CS, Ma Y, Zimmer WE, Goodman SR,
            Eicher EM and Barker JE.
  TITLE     Brain beta spectrin isoform 235 (Spnb-2) maps to mouse chromosome
            11
  JOURNAL   Mamm Genome 3 (5), 293-295 (1992)
   PUBMED   1638088
REFERENCE   8  (residues 1 to 301)
  AUTHORS   Le Roy H, Simon-Chazottes D, Montagutelli X and Guenet JL.
  TITLE     A set of anonymous DNA clones as markers for mouse gene mapping
  JOURNAL   Mamm Genome 3 (4), 244-246 (1992)
   PUBMED   1351769
REFERENCE   9  (residues 1 to 301)
  AUTHORS   Baldacci PA, Richoux V, Renard JP, Guenet JL and Babinet C.
  TITLE     The locus Om, responsible for the DDK syndrome, maps close to Sigje
            on mouse chromosome 11
  JOURNAL   Mamm Genome 2 (2), 100-105 (1992)
   PUBMED   1347470
REFERENCE   10 (residues 1 to 301)
  AUTHORS   Buckwalter MS, Katz RW and Camper SA.
  TITLE     Localization of the panhypopituitary dwarf mutation (df) on mouse
            chromosome 11 in an intersubspecific backcross
  JOURNAL   Genomics 10 (3), 515-526 (1991)
   PUBMED   1889803
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY781653.1, BB857564.1, AK148670.1, AK161229.1, AA798908.1,
            CJ132527.1 and BE655213.1.
            
            On Mar 20, 2014 this sequence version replaced XP_006532730.1.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the central coding region, compared to variant 1.
            The encoded isoform (2) is shorter, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.62997.1, AK148670.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..301
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 33.04 cM"
     Protein         1..301
                     /product="SPARC isoform 2 precursor"
                     /note="basement-membrane protein 40; secreted protein
                     acidic and rich in cysteine; osteonectin"
                     /calculated_mol_wt=32388
     sig_peptide     1..17
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=1952
     Region          69..150
                     /region_name="FSL_SPARC"
                     /note="Follistatin-like SPARC (secreted protein, acidic,
                     and rich in cysteines) domain; SPARC/BM-40/osteonectin is
                     a multifunctional glycoprotein which modulates cellular
                     interaction with the extracellular matrix by its binding
                     to structural matrix proteins...; cd01328"
                     /db_xref="CDD:238649"
     Site            114
                     /site_type="other"
                     /note="N-glycosylation site [posttranslational
                     modification]"
                     /db_xref="CDD:238649"
     Site            114
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000305|PubMed:3427055; propagated from
                     UniProtKB/Swiss-Prot (P07214.1)"
     Region          153..292
                     /region_name="EFh_SPARC_SPARC"
                     /note="EF-hand, extracellular calcium-binding (EC) motif,
                     found in secreted protein acidic and rich in cysteine
                     (SPARC); cd16235"
                     /db_xref="CDD:320014"
     Site            order(160..161,164..165,167..168,171..172,175,179,257,
                     260..261)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:320014"
     Region          225..258
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320014"
     Site            order(237,242,249,272,274,276,283)
                     /site_type="other"
                     /note="Ca binding site [ion binding]"
                     /db_xref="CDD:320014"
     Site            order(247..248,262)
                     /site_type="other"
                     /note="EC/FS-domain interface"
                     /db_xref="CDD:320014"
     Region          260..292
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320014"
     CDS             1..301
                     /gene="Sparc"
                     /gene_synonym="BM-40; ON"
                     /coded_by="NM_001290817.1:307..1212"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2"
                     /db_xref="CCDS:CCDS70189.1"
                     /db_xref="GeneID:20692"
                     /db_xref="MGI:MGI:98373"
ORIGIN      
        1 mrawiffllc lagralaapq tevaeeivee etvveetgvp vganpvqvem gefedgaeet
       61 veevvadnpc qnhhckhgkv celdesntpm cvcqdptscp apigefekvc sndnktfdss
      121 chffatkctl egtkkghklh ldyigpckyi apcldselte fplrmrdwlk nvlvtlyerd
      181 egnnlltekq klrvkkihen ekrleagdhp vellardfek nynmyifpvh wqfgqldqhp
      241 idgylshtel aplraplipm ehcttrffet cdldndkyia leewagcfgi keqdinkdlv
      301 i
//
LOCUS       NP_001240685             179 aa            linear   ROD 09-OCT-2023
DEFINITION  neuronal membrane glycoprotein M6-a isoform 3 [Mus musculus].
ACCESSION   NP_001240685
VERSION     NP_001240685.1
DBSOURCE    REFSEQ: accession NM_001253756.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 179)
  AUTHORS   Li L, Sun Y, Davis AE, Shah SH, Hamed LK, Wu MR, Lin CH, Ding JB
            and Wang S.
  TITLE     Mettl14-mediated m6A modification ensures the cell-cycle
            progression of late-born retinal progenitor cells
  JOURNAL   Cell Rep 42 (6), 112596 (2023)
   PUBMED   37269288
  REMARK    GeneRIF: Mettl14-mediated m[6]A modification ensures the cell-cycle
            progression of late-born retinal progenitor cells.
REFERENCE   2  (residues 1 to 179)
  AUTHORS   Xie W, Zhang A, Huang X, Zhou H, Ying H, Ye C, Ren M, Qian M, Liu X
            and Mo Y.
  TITLE     SILENCING M 6 A READER YTHDC1 REDUCES INFLAMMATORY RESPONSE IN
            SEPSIS-INDUCED CARDIOMYOPATHY BY INHIBITING SERPINA3N EXPRESSION
  JOURNAL   Shock 59 (5), 791-802 (2023)
   PUBMED   36877222
  REMARK    GeneRIF: SILENCING M 6 A READER YTHDC1 REDUCES INFLAMMATORY
            RESPONSE IN SEPSIS-INDUCED CARDIOMYOPATHY BY INHIBITING SERPINA3N
            EXPRESSION.
REFERENCE   3  (residues 1 to 179)
  AUTHORS   Xue A, Huang Y, Li M, Wei Q and Bu Q.
  TITLE     Comprehensive Analysis of Differential m6A RNA Methylomes in the
            Hippocampus of Cocaine-Conditioned Mice
  JOURNAL   Mol Neurobiol 58 (8), 3759-3768 (2021)
   PUBMED   33826069
  REMARK    GeneRIF: Comprehensive Analysis of Differential m6A RNA Methylomes
            in the Hippocampus of Cocaine-Conditioned Mice.
REFERENCE   4  (residues 1 to 179)
  AUTHORS   Bedogni F and Hevner RF.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 179)
  AUTHORS   Ogawa T, Li Y, Lua I, Hartner A and Asahina K.
  TITLE     Isolation of a unique hepatic stellate cell population expressing
            integrin alpha8 from embryonic mouse livers
  JOURNAL   Dev Dyn 247 (6), 867-881 (2018)
   PUBMED   29665133
REFERENCE   6  (residues 1 to 179)
  AUTHORS   Yan Y, Narayanan V and Lagenaur C.
  TITLE     Expression of members of the proteolipid protein gene family in the
            developing murine central nervous system
  JOURNAL   J Comp Neurol 370 (4), 465-478 (1996)
   PUBMED   8807448
REFERENCE   7  (residues 1 to 179)
  AUTHORS   Olinsky S, Loop BT, DeKosky A, Ripepi B, Weng W, Cummins J, Wenger
            SL, Yan Y, Lagenaur C and Narayanan V.
  TITLE     Chromosomal mapping of the human M6 genes
  JOURNAL   Genomics 33 (3), 532-536 (1996)
   PUBMED   8661015
REFERENCE   8  (residues 1 to 179)
  AUTHORS   Shimizu F, Watanabe TK, Fujiwara T, Takahashi E, Nakamura Y and
            Maekawa H.
  TITLE     Isolation and mapping of the human glycoprotein M6 gene (GPM6A) to
            4q33-->q34
  JOURNAL   Cytogenet Cell Genet 74 (1-2), 138-139 (1996)
   PUBMED   8893821
REFERENCE   9  (residues 1 to 179)
  AUTHORS   Yan Y, Lagenaur C and Narayanan V.
  TITLE     Molecular cloning of M6: identification of a PLP/DM20 gene family
  JOURNAL   Neuron 11 (3), 423-431 (1993)
   PUBMED   8398137
REFERENCE   10 (residues 1 to 179)
  AUTHORS   Baumrind NL, Parkinson D, Wayne DB, Heuser JE and Pearlman AL.
  TITLE     EMA: a developmentally regulated cell-surface glycoprotein of CNS
            neurons that is concentrated at the leading edge of growth cones
  JOURNAL   Dev Dyn 194 (4), 311-325 (1992)
   PUBMED   1286213
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY247392.1, AK081877.1, CD354193.1 and BC033357.1.
            
            Transcript Variant: This variant (3) has a different segment in its
            5' UTR and lacks an alternate exon in the 5' coding region, which
            results in the use of a downstream start codon, compared to variant
            1. The resulting protein (isoform 3) is shorter when it is compared
            to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CD354193.1, SRR11927938.2687994.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..179
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 29.33 cM"
     Protein         1..179
                     /product="neuronal membrane glycoprotein M6-a isoform 3"
                     /note="neuronal membrane glycoprotein M6-a"
                     /calculated_mol_wt=20268
     Region          <1..148
                     /region_name="Myelin_PLP"
                     /note="Myelin proteolipid protein (PLP or lipophilin);
                     cl02417"
                     /db_xref="CDD:445775"
     CDS             1..179
                     /gene="Gpm6a"
                     /gene_synonym="Gpm6; M6A"
                     /coded_by="NM_001253756.1:656..1195"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="GeneID:234267"
                     /db_xref="MGI:MGI:107671"
ORIGIN      
        1 mvegffttga ikdlygdfki ttcgrcvsaw fimltylfml awlgvtafts lpvymyfnvw
       61 ticrnttlve ganlcldlrq fgivtigeek kictasenfl rmcestelnm tfhlfivala
      121 gagaaviamv hylmvlsanw ayvkdacrmq kyedikskee qelhdihstr skerlnayt
//
LOCUS       NP_034561                836 aa            linear   ROD 09-OCT-2023
DEFINITION  hypoxia-inducible factor 1-alpha isoform 2 [Mus musculus].
ACCESSION   NP_034561
VERSION     NP_034561.2
DBSOURCE    REFSEQ: accession NM_010431.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 836)
  AUTHORS   Xu R, Shen S, Wang D, Ye J, Song S, Wang Z and Yue Z.
  TITLE     The role of HIF-1alpha-mediated autophagy in ionizing
            radiation-induced testicular injury
  JOURNAL   J Mol Histol 54 (5), 439-451 (2023)
   PUBMED   37728670
  REMARK    GeneRIF: The role of HIF-1alpha-mediated autophagy in ionizing
            radiation-induced testicular injury.
REFERENCE   2  (residues 1 to 836)
  AUTHORS   Yang Z, Su W, Wei X, Qu S, Zhao D, Zhou J, Wang Y, Guan Q, Qin C,
            Xiang J, Zen K and Yao B.
  TITLE     HIF-1alpha drives resistance to ferroptosis in solid tumors by
            promoting lactate production and activating SLC1A1
  JOURNAL   Cell Rep 42 (8), 112945 (2023)
   PUBMED   37542723
  REMARK    GeneRIF: HIF-1alpha drives resistance to ferroptosis in solid
            tumors by promoting lactate production and activating SLC1A1.
REFERENCE   3  (residues 1 to 836)
  AUTHORS   Dery KJ, Kojima H, Kageyama S, Kadono K, Hirao H, Cheng B, Zhai Y,
            Farmer DG, Kaldas FM, Yuan X, Eltzschig HK and Kupiec-Weglinski JW.
  TITLE     Alternative splicing of CEACAM1 by hypoxia-inducible factor-1alpha
            enhances tolerance to hepatic ischemia in mice and humans
  JOURNAL   Sci Transl Med 15 (707), eadf2059 (2023)
   PUBMED   37531413
  REMARK    GeneRIF: Alternative splicing of CEACAM1 by hypoxia-inducible
            factor-1alpha enhances tolerance to hepatic ischemia in mice and
            humans.
REFERENCE   4  (residues 1 to 836)
  AUTHORS   Guo Z, Yu X, Zhao S, Zhong X, Huang D, Feng R, Li P, Fang Z, Hu Y,
            Zhang Z, Abdurahman M, Huang L, Zhao Y, Wang X, Ge J and Li H.
  TITLE     SIRT6 deficiency in endothelial cells exacerbates oxidative stress
            by enhancing HIF1alpha accumulation and H3K9 acetylation at the
            Ero1alpha promoter
  JOURNAL   Clin Transl Med 13 (8), e1377 (2023)
   PUBMED   37598403
  REMARK    GeneRIF: SIRT6 deficiency in endothelial cells exacerbates
            oxidative stress by enhancing HIF1alpha accumulation and H3K9
            acetylation at the Ero1alpha promoter.
REFERENCE   5  (residues 1 to 836)
  AUTHORS   Zhang G, Liu B, Yang Y, Xie S, Chen L, Luo H, Zhong J, Wei Y, Guo
            F, Gan J, Zhu F, Xu L, Li Q, Shen Y, Zhang H, Liu Y, Li R, Deng H
            and Yang H.
  TITLE     Mitochondrial UQCC3 controls embryonic and tumor angiogenesis by
            regulating VEGF expression
  JOURNAL   iScience 26 (8), 107370 (2023)
   PUBMED   37539028
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 836)
  AUTHORS   Li H, Ko HP and Whitlock JP.
  TITLE     Induction of phosphoglycerate kinase 1 gene expression by hypoxia.
            Roles of Arnt and HIF1alpha
  JOURNAL   J Biol Chem 271 (35), 21262-21267 (1996)
   PUBMED   8702901
REFERENCE   7  (residues 1 to 836)
  AUTHORS   Wood SM, Gleadle JM, Pugh CW, Hankinson O and Ratcliffe PJ.
  TITLE     The role of the aryl hydrocarbon receptor nuclear translocator
            (ARNT) in hypoxic induction of gene expression. Studies in
            ARNT-deficient cells
  JOURNAL   J Biol Chem 271 (25), 15117-15123 (1996)
   PUBMED   8662957
REFERENCE   8  (residues 1 to 836)
  AUTHORS   Semenza GL, Rue EA, Iyer NV, Pang MG and Kearns WG.
  TITLE     Assignment of the hypoxia-inducible factor 1alpha gene to a region
            of conserved synteny on mouse chromosome 12 and human chromosome
            14q
  JOURNAL   Genomics 34 (3), 437-439 (1996)
   PUBMED   8786149
REFERENCE   9  (residues 1 to 836)
  AUTHORS   Wenger RH, Rolfs A, Marti HH, Guenet JL and Gassmann M.
  TITLE     Nucleotide sequence, chromosomal assignment and mRNA expression of
            mouse hypoxia-inducible factor-1 alpha
  JOURNAL   Biochem Biophys Res Commun 223 (1), 54-59 (1996)
   PUBMED   8660378
REFERENCE   10 (residues 1 to 836)
  AUTHORS   Obara N and Takeda M.
  TITLE     Expression of neural cell adhesion molecule (NCAM) during the first
            molar development in the mouse
  JOURNAL   Anat Embryol (Berl) 187 (3), 209-219 (1993)
   PUBMED   8470821
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124712.5.
            
            On Apr 1, 2009 this sequence version replaced NP_034561.1.
            
            Summary: This gene encodes the alpha subunit which, along with the
            beta subunit, forms a heterodimeric transcription factor that
            regulates the cellular and developmental response to reduced oxygen
            tension. The transcription factor has been shown to regulate genes
            involved in several biological processes, including erythropoiesis
            and angiogenesis which aid in increased delivery of oxygen to
            hypoxic regions. The transcription factor also plays a role in the
            induction of genes involved in cell proliferation and survival,
            energy metabolism, apoptosis, and glucose and iron metabolism.
            Alternative splicing results in multiple transcript variants
            encoding different isoforms. [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 5' coding region, compared to variant 1. The
            encoded isoform (2) is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK150367.1, BC026139.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..836
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 31.99 cM"
     Protein         1..836
                     /product="hypoxia-inducible factor 1-alpha isoform 2"
                     /note="hypoxia-inducible factor 1-alpha; ARNT-interacting
                     protein"
                     /calculated_mol_wt=93385
     Region          1..401
                     /region_name="Interaction with TSGA10.
                     /evidence=ECO:0000269|PubMed:16777103"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Region          1..30
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Region          13..83
                     /region_name="bHLH-PAS_HIF1a_PASD8"
                     /note="basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS)
                     domain found in hypoxia-inducible factor 1-alpha (HIF1a)
                     and similar proteins; cd19727"
                     /db_xref="CDD:381570"
     Site            order(18..19,21..23,26..27,29..30,55..56)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381570"
     Region          21..30
                     /region_name="DNA-binding.
                     /evidence=ECO:0000269|PubMed:26245371"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Site            order(32..33,35..36,39..40,43..44,55..57,60..61,64,67..68,
                     71)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:381570"
     Region          93..148
                     /region_name="PAS"
                     /note="PAS domain; smart00091"
                     /db_xref="CDD:214512"
     Region          170..191
                     /region_name="Required for heterodimer formation with
                     ARNT. /evidence=ECO:0000269|PubMed:26245371"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Site            247
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK1.
                     /evidence=ECO:0000250|UniProtKB:Q16665; propagated from
                     UniProtKB/Swiss-Prot (Q61221.3)"
     Region          254..339
                     /region_name="PAS_3"
                     /note="PAS fold; pfam08447"
                     /db_xref="CDD:430001"
     Site            order(255,259,265,278..281,307,312)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:238075"
     Site            order(275,279,287,290..291,319,321)
                     /site_type="other"
                     /note="heme pocket [chemical binding]"
                     /db_xref="CDD:238075"
     Region          380..417
                     /region_name="N-terminal VHL recognition site"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Region          401..613
                     /region_name="ODD"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Site            402
                     /site_type="hydroxylation"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:Q16665; propagated from
                     UniProtKB/Swiss-Prot (Q61221.3)"
     Region          492..511
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Region          544..588
                     /region_name="NTAD"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Site            545
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:Q16665; propagated from
                     UniProtKB/Swiss-Prot (Q61221.3)"
     Region          564..593
                     /region_name="HIF-1"
                     /note="Hypoxia-inducible factor-1; pfam11413"
                     /db_xref="CDD:431874"
     Site            564
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by GSK3-beta.
                     /evidence=ECO:0000250|UniProtKB:Q16665; propagated from
                     UniProtKB/Swiss-Prot (Q61221.3)"
     Site            568
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by GSK3-beta.
                     /evidence=ECO:0000250|UniProtKB:Q16665; propagated from
                     UniProtKB/Swiss-Prot (Q61221.3)"
     Region          569..585
                     /region_name="C-terminal VHL recognition site"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Site            577
                     /site_type="hydroxylation"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:Q16665; propagated from
                     UniProtKB/Swiss-Prot (Q61221.3)"
     Region          589..795
                     /region_name="ID"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Site            589
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PLK3.
                     /evidence=ECO:0000250|UniProtKB:Q16665; propagated from
                     UniProtKB/Swiss-Prot (Q61221.3)"
     Region          593..684
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Site            602
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by GSK3-beta.
                     /evidence=ECO:0000250|UniProtKB:Q16665; propagated from
                     UniProtKB/Swiss-Prot (Q61221.3)"
     Site            668
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PLK3.
                     /evidence=ECO:0000250|UniProtKB:Q16665; propagated from
                     UniProtKB/Swiss-Prot (Q61221.3)"
     Region          707..734
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Site            719
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q16665; propagated from
                     UniProtKB/Swiss-Prot (Q61221.3)"
     Region          728..731
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Region          796..836
                     /region_name="CTAD"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Region          799..835
                     /region_name="HIF-1a_CTAD"
                     /note="HIF-1 alpha C terminal transactivation domain;
                     pfam08778"
                     /db_xref="CDD:430212"
     Site            813
                     /site_type="hydroxylation"
                     /note="(3S)-3-hydroxyasparagine.
                     /evidence=ECO:0000250|UniProtKB:Q16665; propagated from
                     UniProtKB/Swiss-Prot (Q61221.3)"
     CDS             1..836
                     /gene="Hif1a"
                     /gene_synonym="bHLHe78; HIF-1-alpha; HIF1-alpha;
                     HIF1alpha; MOP1"
                     /coded_by="NM_010431.3:290..2800"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS25977.1"
                     /db_xref="GeneID:15251"
                     /db_xref="MGI:MGI:106918"
ORIGIN      
        1 megaggenek kkmsserrke ksrdaarsrr skesevfyel ahqlplphnv sshldkasvm
       61 rltisylrvr klldagglds edemkaqmdc fylkaldgfv mvltddgdmv yisdnvnkym
      121 gltqfeltgh svfdfthpcd heemremlth rngpvrkgke lntqrsfflr mkctltsrgr
      181 tmniksatwk vlhctghihv ydtnsnqpqc gykkppmtcl vlicepiphp snieipldsk
      241 tflsrhsldm kfsycderit elmgyepeel lgrsiyeyyh aldsdhltkt hhdmftkgqv
      301 ttgqyrmlak rggyvwvetq atviyntkns qpqcivcvny vvsgiiqhdl ifslqqtesv
      361 lkpvessdmk mtqlftkves edtsclfdkl kkepdaltll apaagdtiis ldfgsddtet
      421 edqqledvpl yndvmfpssn eklninlams plpssetpkp lrssadpaln qevalkless
      481 peslglsftm pqiqdqpasp sdgstrqssp erllqenvnt pnfsqpnsps eycfdvdsdm
      541 vnvfklelve klfaedteak npfstqdtdl dlemlapyip mdddfqlrsf dqlsplesns
      601 psppsmstvt gfqqtqlqkp titatattta ttdesktetk dnkedikili aspsstqvpq
      661 etttakasay sgthsrtasp dragkrvieq tdkahprsln lsatlnqrnt vpeeelnpkt
      721 iasqnaqrkr kmehdgslfq aagigtllqq pgdcaptmsl swkrvkgfis seqngteqkt
      781 iilipsdlac rllgqsmdes glpqltsydc evnapiqgsr nllqgeellr aldqvn
//
LOCUS       NP_035617                748 aa            linear   ROD 09-OCT-2023
DEFINITION  signal transducer and activator of transcription 4 [Mus musculus].
ACCESSION   NP_035617 XP_988970
VERSION     NP_035617.1
DBSOURCE    REFSEQ: accession NM_011487.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 748)
  AUTHORS   Zhang XL, Hollander CM, Khan MY, D'silva M, Ma H, Yang X, Bai R,
            Keeter CK, Galkina EV, Nadler JL and Stanton PK.
  TITLE     Myeloid cell deficiency of the inflammatory transcription factor
            Stat4 protects long-term synaptic plasticity from the effects of a
            high-fat, high-cholesterol diet
  JOURNAL   Commun Biol 6 (1), 967 (2023)
   PUBMED   37783748
  REMARK    GeneRIF: Myeloid cell deficiency of the inflammatory transcription
            factor Stat4 protects long-term synaptic plasticity from the
            effects of a high-fat, high-cholesterol diet.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 748)
  AUTHORS   Keeter WC, Moriarty AK, Akers R, Ma S, Mussbacher M, Nadler JL and
            Galkina EV.
  TITLE     Neutrophil-specific STAT4 deficiency attenuates atherosclerotic
            burden and improves plaque stability via reduction in neutrophil
            activation and recruitment into aortas of Ldlr-/- mice
  JOURNAL   Front Cardiovasc Med 10, 1175673 (2023)
   PUBMED   37396582
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 748)
  AUTHORS   Buzzelli AA, McWilliams IL, Shin B, Bryars MT and Harrington LE.
  TITLE     Intrinsic STAT4 Expression Controls Effector CD4 T Cell Migration
            and Th17 Pathogenicity
  JOURNAL   J Immunol 210 (11), 1667-1676 (2023)
   PUBMED   37093664
REFERENCE   4  (residues 1 to 748)
  AUTHORS   Hildreth AD, Padilla ET, Tafti RY, Legala AR and O'Sullivan TE.
  TITLE     Sterile liver injury induces a protective tissue-resident cDC1-ILC1
            circuit through cDC1-intrinsic cGAS-STING-dependent IL-12
            production
  JOURNAL   Cell Rep 42 (2), 112141 (2023)
   PUBMED   36807146
REFERENCE   5  (residues 1 to 748)
  AUTHORS   Liang Y, Pan HF and Ye DQ.
  TITLE     Therapeutic potential of STAT4 in autoimmunity
  JOURNAL   Expert Opin Ther Targets 18 (8), 945-960 (2014)
   PUBMED   24844303
  REMARK    Review article
REFERENCE   6  (residues 1 to 748)
  AUTHORS   Wang Y, Feng D, Wang H, Xu MJ, Park O, Li Y and Gao B.
  TITLE     STAT4 knockout mice are more susceptible to concanavalin A-induced
            T-cell hepatitis
  JOURNAL   Am J Pathol 184 (6), 1785-1794 (2014)
   PUBMED   24731448
REFERENCE   7  (residues 1 to 748)
  AUTHORS   Copeland NG, Gilbert DJ, Schindler C, Zhong Z, Wen Z, Darnell JE
            Jr, Mui AL, Miyajima A, Quelle FW, Ihle JN et al.
  TITLE     Distribution of the mammalian Stat gene family in mouse chromosomes
  JOURNAL   Genomics 29 (1), 225-228 (1995)
   PUBMED   8530075
REFERENCE   8  (residues 1 to 748)
  AUTHORS   Yamamoto K, Quelle FW, Thierfelder WE, Kreider BL, Gilbert DJ,
            Jenkins NA, Copeland NG, Silvennoinen O and Ihle JN.
  TITLE     Stat4, a novel gamma interferon activation site-binding protein
            expressed in early myeloid differentiation
  JOURNAL   Mol Cell Biol 14 (7), 4342-4349 (1994)
   PUBMED   8007943
REFERENCE   9  (residues 1 to 748)
  AUTHORS   Zhong Z, Wen Z and Darnell JE Jr.
  TITLE     Stat3 and Stat4: members of the family of signal transducers and
            activators of transcription
  JOURNAL   Proc Natl Acad Sci U S A 91 (11), 4806-4810 (1994)
   PUBMED   7545930
REFERENCE   10 (residues 1 to 748)
  AUTHORS   Zhong Z, Wen Z and Darnell JE Jr.
  TITLE     Stat3: a STAT family member activated by tyrosine phosphorylation
            in response to epidermal growth factor and interleukin-6
  JOURNAL   Science 264 (5155), 95-98 (1994)
   PUBMED   8140422
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY097735.1, AC108840.13,
            BY750146.1, AK132675.1 and BF020635.1.
            
            On May 4, 2006 this sequence version replaced XP_988970.1.
            
            Summary: The protein encoded by this gene is a member of the STAT
            family of transcription factors. In response to cytokines and
            growth factors, STAT family members are phosphorylated by the
            receptor associated kinases, and then form homo- or heterodimers
            that translocate to the cell nucleus where they act as
            transcription activators. Homozygous knockout mice for this gene
            exhibit reduced inflammation and cytokine production in response to
            immune challenge. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Apr 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U09351.1, BC098499.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN00849388
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..748
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 26.67 cM"
     Protein         1..748
                     /product="signal transducer and activator of transcription
                     4"
                     /calculated_mol_wt=85723
     Region          2..121
                     /region_name="STAT_int"
                     /note="STAT protein, protein interaction domain;
                     smart00964"
                     /db_xref="CDD:214942"
     Region          140..312
                     /region_name="STAT4_CCD"
                     /note="Coiled-coil domain of Signal Transducer and
                     Activator of Transcription 4 (STAT4); cd16854"
                     /db_xref="CDD:341079"
     Site            order(141..164,208..234,258..279)
                     /site_type="other"
                     /note="coiled-coil motif"
                     /db_xref="CDD:341079"
     Region          316..473
                     /region_name="STAT4_DBD"
                     /note="DNA-binding domain of Signal Transducer and
                     Activator of Transcription 4 (STAT4); cd16848"
                     /db_xref="CDD:341086"
     Region          553..700
                     /region_name="SH2_STAT4"
                     /note="Src homology 2 (SH2) domain found in signal
                     transducer and activator of transcription (STAT)
                     4proteins; cd10375"
                     /db_xref="CDD:198238"
     Site            order(580,598,624,626)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198238"
     Site            order(625,641)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198238"
     Site            order(635..636,698)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:198238"
     Site            667
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q14765; propagated from
                     UniProtKB/Swiss-Prot (P42228.1)"
     Site            693
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by JAK.
                     /evidence=ECO:0000250|UniProtKB:Q14765; propagated from
                     UniProtKB/Swiss-Prot (P42228.1)"
     Site            721
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q14765; propagated from
                     UniProtKB/Swiss-Prot (P42228.1)"
     CDS             1..748
                     /gene="Stat4"
                     /coded_by="NM_011487.5:491..2737"
                     /db_xref="CCDS:CCDS14943.1"
                     /db_xref="GeneID:20849"
                     /db_xref="MGI:MGI:103062"
ORIGIN      
        1 msqwnqvqql eikfleqvdq fyddnfpmei rhllaqwiet qdwevasnne tmatillqnl
       61 liqldeqlgr vskeknllli hnlkrirkvl qgkfhgnpmh vavvisnclr eerrilaaan
      121 mpiqgpleks lqsssvserq rnvehkvsai knsvqmteqd tkyledlqde fdyryktiqt
      181 mdqgdknsil vnqevltlqe mlnsldfkrk ealskmtqiv netdllmnsm lleelqdwkk
      241 rqqiaciggp lhngldqlqn cftllaeslf qlrqqleklq eqstkmtyeg dpipaqrahl
      301 leratfliyn lfknsfvver qpcmpthpqr pmvlktliqf tvklrllikl pelnyqvkvk
      361 asidknvstl snrrfvlcgt hvkamssees sngslsvefr hlqpkemkcs tgskgnegch
      421 mvteelhsit fetqiclygl tinletsslp vvmisnvsql pnawasiiwy nvstndsqnl
      481 vffnnppsvt lgqllevmsw qfssyvgrgl nseqlnmlae kltvqsnynd ghltwakfck
      541 ehlpgktftf wtwleaildl ikkhilplwi dgyimgfvsk ekerlllkdk mpgtfllrfs
      601 eshlggitft wvdqsengev rfhsvepynk grlsalpfad ilrdykvima enipenplky
      661 lypdipkdka fgkhyssqpc evsrptergd kgyvpsvfip istirsdste pqspsdllpm
      721 spsayavlre nlspttieta mnspysae
//
LOCUS       NP_001077404             591 aa            linear   ROD 09-OCT-2023
DEFINITION  parathyroid hormone/parathyroid hormone-related peptide receptor
            precursor [Mus musculus].
ACCESSION   NP_001077404
VERSION     NP_001077404.1
DBSOURCE    REFSEQ: accession NM_001083935.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 591)
  AUTHORS   Amano K, Kitaoka Y, Kato S, Fujiwara M, Okuzaki D, Aikawa T, Kogo M
            and Iida S.
  TITLE     Pth1r Signal in Gli1+ Cells Maintains Postnatal Cranial Base
            Synchondrosis
  JOURNAL   J Dent Res 102 (11), 1241-1251 (2023)
   PUBMED   37575041
  REMARK    GeneRIF: Pth1r Signal in Gli1+ Cells Maintains Postnatal Cranial
            Base Synchondrosis.
REFERENCE   2  (residues 1 to 591)
  AUTHORS   Liu H, Wada A, Le I, Le PT, Lee AWF, Zhou J, Gori F, Baron R and
            Rosen CJ.
  TITLE     PTH regulates osteogenesis and suppresses adipogenesis through
            Zfp467 in a feed-forward, PTH1R-cyclic AMP-dependent manner
  JOURNAL   Elife 12, e83345 (2023)
   PUBMED   37159501
  REMARK    GeneRIF: PTH regulates osteogenesis and suppresses adipogenesis
            through Zfp467 in a feed-forward, PTH1R-cyclic AMP-dependent
            manner.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 591)
  AUTHORS   Chu TL, Chen P, Yu AX, Kong M, Tan Z, Tsang KY, Zhou Z and Cheah
            KSE.
  TITLE     MMP14 cleaves PTH1R in the chondrocyte-derived osteoblast lineage,
            curbing signaling intensity for proper bone anabolism
  JOURNAL   Elife 12, e82142 (2023)
   PUBMED   36892459
  REMARK    GeneRIF: MMP14 cleaves PTH1R in the chondrocyte-derived osteoblast
            lineage, curbing signaling intensity for proper bone anabolism.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 591)
  AUTHORS   Wang F, Rummukainen P, Pehkonen M, Saamanen AM, Heino TJ and
            Kiviranta R.
  TITLE     Mesenchymal cell-derived Wnt1 signaling regulates subchondral bone
            remodeling but has no effects on the development of growth plate or
            articular cartilage in mice
  JOURNAL   Bone 163, 116497 (2022)
   PUBMED   35863746
REFERENCE   5  (residues 1 to 591)
  AUTHORS   Kimura T, Panaroni C, Rankin EB, Purton LE and Wu JY.
  TITLE     Loss of Parathyroid Hormone Receptor Signaling in Osteoprogenitors
            Is Associated With Accumulation of Multiple Hematopoietic Lineages
            in the Bone Marrow
  JOURNAL   J Bone Miner Res 37 (7), 1321-1334 (2022)
   PUBMED   35490308
  REMARK    GeneRIF: Loss of Parathyroid Hormone Receptor Signaling in
            Osteoprogenitors Is Associated With Accumulation of Multiple
            Hematopoietic Lineages in the Bone Marrow.
REFERENCE   6  (residues 1 to 591)
  AUTHORS   McCuaig KA, Lee HS, Clarke JC, Assar H, Horsford J and White JH.
  TITLE     Parathyroid hormone/parathyroid hormone related peptide receptor
            gene transcripts are expressed from tissue-specific and ubiquitous
            promoters
  JOURNAL   Nucleic Acids Res 23 (11), 1948-1955 (1995)
   PUBMED   7596823
  REMARK    Erratum:[Nucleic Acids Res 1995 Aug 11;23(15):3082]
REFERENCE   7  (residues 1 to 591)
  AUTHORS   Karperien M, van Dijk TB, Hoeijmakers T, Cremers F, Abou-Samra AB,
            Boonstra J, de Laat SW and Defize LH.
  TITLE     Expression pattern of parathyroid hormone/parathyroid hormone
            related peptide receptor mRNA in mouse postimplantation embryos
            indicates involvement in multiple developmental processes
  JOURNAL   Mech Dev 47 (1), 29-42 (1994)
   PUBMED   7524627
REFERENCE   8  (residues 1 to 591)
  AUTHORS   Kong XF, Schipani E, Lanske B, Joun H, Karperien M, Defize LH,
            Juppner H, Potts JT Jr, Segre GV, Kronenberg HM et al.
  TITLE     The rat, mouse and human genes encoding the receptor for
            parathyroid hormone and parathyroid hormone-related peptide are
            highly homologous
  JOURNAL   Biochem Biophys Res Commun 200 (3), 1290-1299 (1994)
   PUBMED   8185578
  REMARK    Erratum:[Biochem Biophys Res Commun. 1994 Jun 15;201(2):1058. PMID:
            8002976]
REFERENCE   9  (residues 1 to 591)
  AUTHORS   Pausova Z, Bourdon J, Clayton D, Mattei MG, Seldin MF, Janicic N,
            Riviere M, Szpirer J, Levan G, Szpirer C et al.
  TITLE     Cloning of a parathyroid hormone/parathyroid hormone-related
            peptide receptor (PTHR) cDNA from a rat osteosarcoma (UMR 106) cell
            line: chromosomal assignment of the gene in the human, mouse, and
            rat genomes
  JOURNAL   Genomics 20 (1), 20-26 (1994)
   PUBMED   8020952
REFERENCE   10 (residues 1 to 591)
  AUTHORS   Seldin MF, Mattei MG and Hendy GN.
  TITLE     Localization of mouse parathyroid hormone-like peptide gene (Pthlh)
            to distal chromosome 6 using interspecific backcross mice and in
            situ hybridization
  JOURNAL   Cytogenet Cell Genet 60 (3-4), 252-254 (1992)
   PUBMED   1354597
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC139378.4, CB192926.1, BC051981.1 and AI607947.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 3. Variants 1, 2, and 3 encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X78936.1, SRR7974084.4357.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN01164140
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..591
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 60.56 cM"
     Protein         1..591
                     /product="parathyroid hormone/parathyroid hormone-related
                     peptide receptor precursor"
                     /note="parathyroid hormone receptor 1; parathyroid
                     hormone/parathyroid hormone-related peptide receptor; PTH1
                     receptor; PTH/PTHr receptor; PTH/PTHrP type I receptor;
                     PTH-related peptide receptor; PTH/PTHrP receptor"
                     /calculated_mol_wt=63570
     sig_peptide     1..28
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=2820
     Region          67..104
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P41593.2)"
     Region          105..170
                     /region_name="HRM"
                     /note="Hormone receptor domain; pfam02793"
                     /db_xref="CDD:397086"
     Site            151
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P41593.2)"
     Site            161
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P41593.2)"
     Site            166
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P41593.2)"
     Site            176
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P41593.2)"
     Region          184..476
                     /region_name="7tm_GPCRs"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; cl28897"
                     /db_xref="CDD:452889"
     Region          187..211
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:410628"
     Site            189..212
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P41593.2)"
     Region          220..241
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:410628"
     Site            220..239
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P41593.2)"
     Region          282..304
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:410628"
     Site            283..306
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P41593.2)"
     Site            321..342
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P41593.2)"
     Region          323..339
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:410628"
     Region          356..379
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:410628"
     Site            362..382
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P41593.2)"
     Region          407..429
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:410628"
     Site            410..428
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P41593.2)"
     Region          438..463
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:410628"
     Site            441..463
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P41593.2)"
     Region          474..477
                     /region_name="Important for interaction with G proteins.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P41593.2)"
     CDS             1..591
                     /gene="Pth1r"
                     /gene_synonym="PPR; Pthr; Pthr1"
                     /coded_by="NM_001083935.1:278..2053"
                     /db_xref="CCDS:CCDS52940.1"
                     /db_xref="GeneID:19228"
                     /db_xref="MGI:MGI:97801"
ORIGIN      
        1 mgtariapsl alllccpvls sayalvdadd vftkeeqifl lhraqaqcdk llkevlhtaa
       61 nimesdkgwt pastsgkprk ekapgkfype skenkdvptg srrrgrpclp ewdnivcwpl
      121 gapgevvavp cpdyiydfnh kghayrrcdr ngswevvpgh nrtwanysec lkfmtnetre
      181 revfdrlgmi ytvgysmsla sltvavlila yfrrlhctrn yihmhmflsf mlraasifvk
      241 davlysgftl deaerlteee lhiiaqvppp paaaavgyag crvavtffly flatnyywil
      301 veglylhsli fmaffsekky lwgftifgwg lpavfvavwv gvratlantg cwdlssghkk
      361 wiiqvpilas vvlnfilfin iirvlatklr etnagrcdtr qqyrkllrst lvlvplfgvh
      421 ytvfmalpyt evsgtlwqiq mhyemlfnsf qgffvaiiyc fcngevqaei rkswsrwtla
      481 ldfkrkarsg sssysygpmv shtsvtnvgp raglslplsp rllpattngh sqlpghakpg
      541 apaienetip vtmtvpkddg flngscsgld eeasgsarpp pllqeewetv m
//
LOCUS       NP_001193311             333 aa            linear   ROD 09-OCT-2023
DEFINITION  mitochondrial antiviral-signaling protein isoform 2 [Mus musculus].
ACCESSION   NP_001193311
VERSION     NP_001193311.1
DBSOURCE    REFSEQ: accession NM_001206382.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 333)
  AUTHORS   Liu F, Zhuang W, Song B, Yang Y, Liu J, Zheng Y, Liu B, Zheng J,
            Zhao W and Gao C.
  TITLE     MAVS-loaded unanchored Lys63-linked polyubiquitin chains activate
            the RIG-I-MAVS signaling cascade
  JOURNAL   Cell Mol Immunol 20 (10), 1186-1202 (2023)
   PUBMED   37582970
  REMARK    GeneRIF: MAVS-loaded unanchored Lys63-linked polyubiquitin chains
            activate the RIG-I-MAVS signaling cascade.
REFERENCE   2  (residues 1 to 333)
  AUTHORS   Ingle H, Makimaa H, Aggarwal S, Deng H, Foster L, Li Y, Kennedy EA,
            Peterson ST, Wilen CB, Lee S, Suthar MS and Baldridge MT.
  TITLE     IFN-lambda derived from nonsusceptible enterocytes acts on tuft
            cells to limit persistent norovirus
  JOURNAL   Sci Adv 9 (37), eadi2562 (2023)
   PUBMED   37703370
REFERENCE   3  (residues 1 to 333)
  AUTHORS   He QQ, Huang Y, Nie L, Ren S, Xu G, Deng F, Cheng Z, Zuo Q, Zhang
            L, Cai H, Wang Q, Wang F, Ren H, Yan H, Xu K, Zhou L, Lu M, Lu Z,
            Zhu Y and Liu S.
  TITLE     MAVS integrates glucose metabolism and RIG-I-like receptor
            signaling
  JOURNAL   Nat Commun 14 (1), 5343 (2023)
   PUBMED   37660168
  REMARK    GeneRIF: MAVS integrates glucose metabolism and RIG-I-like receptor
            signaling.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 333)
  AUTHORS   Li J, Zhang R, Wang C, Zhu J, Ren M, Jiang Y, Hou X, Du Y, Wu Q, Qi
            S, Li L, Chen S, Yang H and Hou F.
  TITLE     WDR77 inhibits prion-like aggregation of MAVS to limit antiviral
            innate immune response
  JOURNAL   Nat Commun 14 (1), 4824 (2023)
   PUBMED   37563140
  REMARK    GeneRIF: WDR77 inhibits prion-like aggregation of MAVS to limit
            antiviral innate immune response.
            Erratum:[Nat Commun. 2023 Sep 25;14(1):5960. PMID: 37749076]
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 333)
  AUTHORS   Wang H, Sun W, Traba J, Wu J, Qi CF, Amo L, Kole HK, Scott B, Singh
            K, Sack MN and Bolland S.
  TITLE     MAVS Positively Regulates Mitochondrial Integrity and Metabolic
            Fitness in B Cells
  JOURNAL   Immunohorizons 7 (8), 587-599 (2023)
   PUBMED   37610299
  REMARK    GeneRIF: MAVS Positively Regulates Mitochondrial Integrity and
            Metabolic Fitness in B Cells.
REFERENCE   6  (residues 1 to 333)
  AUTHORS   Kumar H, Kawai T, Kato H, Sato S, Takahashi K, Coban C, Yamamoto M,
            Uematsu S, Ishii KJ, Takeuchi O and Akira S.
  TITLE     Essential role of IPS-1 in innate immune responses against RNA
            viruses
  JOURNAL   J Exp Med 203 (7), 1795-1803 (2006)
   PUBMED   16785313
  REMARK    GeneRIF: IPS-1 is the sole adapter in both retinoic acid-inducible
            gene (RIG-I) and melanoma differentiation-associated gene 5 (Mda5)
            signaling that mediates effective responses against a variety of
            RNA viruses.
REFERENCE   7  (residues 1 to 333)
  AUTHORS   Sun Q, Sun L, Liu HH, Chen X, Seth RB, Forman J and Chen ZJ.
  TITLE     The specific and essential role of MAVS in antiviral innate immune
            responses
  JOURNAL   Immunity 24 (5), 633-642 (2006)
   PUBMED   16713980
REFERENCE   8  (residues 1 to 333)
  AUTHORS   Meylan E, Curran J, Hofmann K, Moradpour D, Binder M,
            Bartenschlager R and Tschopp J.
  TITLE     Cardif is an adaptor protein in the RIG-I antiviral pathway and is
            targeted by hepatitis C virus
  JOURNAL   Nature 437 (7062), 1167-1172 (2005)
   PUBMED   16177806
REFERENCE   9  (residues 1 to 333)
  AUTHORS   Xu LG, Wang YY, Han KJ, Li LY, Zhai Z and Shu HB.
  TITLE     VISA is an adapter protein required for virus-triggered IFN-beta
            signaling
  JOURNAL   Mol Cell 19 (6), 727-740 (2005)
   PUBMED   16153868
  REMARK    GeneRIF: Data suggest that VISA is critically involved in both
            virus-triggered TLR3-independent and TLR3-mediated antiviral
            interferon signaling.
REFERENCE   10 (residues 1 to 333)
  AUTHORS   Seth RB, Sun L, Ea CK and Chen ZJ.
  TITLE     Identification and characterization of MAVS, a mitochondrial
            antiviral signaling protein that activates NF-kappaB and IRF 3
  JOURNAL   Cell 122 (5), 669-682 (2005)
   PUBMED   16125763
  REMARK    GeneRIF: The overexpression of mitochondrial antiviral
            signaling(MAVS)induces the expression of IFN-beta through
            activation of NF-kappaB and IRF 3, thus boosting antiviral
            immunity.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK153748.1 and AL808128.4.
            
            Transcript Variant: This variant (3) differs in the 5' UTR, and
            initiates translation at a downstream, in-frame start codon,
            compared to variant 1. Variants 3 and 4 encode the same isoform
            (2), which has a shorter N-terminus, compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK153748.1, SRR9219380.27689.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: PMID: 16125763; reported by
                                                  MitoCarta
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..333
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 63.3 cM"
     Protein         1..333
                     /product="mitochondrial antiviral-signaling protein
                     isoform 2"
                     /note="IFN-beta promoter stimulator-1; mitochondrial
                     anti-viral signaling protein; virus-induced signaling
                     adapter; CARD adapter inducing interferon beta; interferon
                     beta promoter stimulator protein 1"
                     /calculated_mol_wt=34258
     CDS             1..333
                     /gene="Mavs"
                     /gene_synonym="cardif; D430028G21Rik; IPS-1; Visa"
                     /coded_by="NM_001206382.1:725..1726"
                     /note="isoform 2 is encoded by transcript variant 3"
                     /db_xref="GeneID:228607"
                     /db_xref="MGI:MGI:2444773"
ORIGIN      
        1 msggslipsp nqqalspqps rehqeqepel ggahaanvas vpiatygpvs ptvsfqplpr
       61 talrtnllsg vtvsalsadt slsssstgsa fakgagdqak aatcfsttlt nsvttssvps
      121 prlvpvktms sklplsskst aamtstvltn tapsklpsns vyagtvpsrv pasvakapan
      181 tippernskq aketpegpat kvttggnqtg pnssirslhs gpemskpgvl vsqldepfsa
      241 csvdlaisps sslvsepnhg peeneyssfr iqvdespsad llgspeplat qqpqeeeehc
      301 assmpwakwl gatsallavf lavmlyrsrr laq
//
LOCUS       NP_001259026             134 aa            linear   ROD 09-OCT-2023
DEFINITION  fatty acid-binding protein 5 isoform 2 [Mus musculus].
ACCESSION   NP_001259026
VERSION     NP_001259026.1
DBSOURCE    REFSEQ: accession NM_001272097.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 134)
  AUTHORS   Penman SL, Roeder NM, Berthold EC, Senetra AS, Marion M, Richardson
            BJ, White O, Fearby NL, McCurdy CR, Hamilton J, Sharma A and Thanos
            PK.
  TITLE     FABP5 is important for cognitive function and is an important
            regulator of the physiological effects and pharmacokinetics of
            acute Delta9 tetrahydrocannabinol inhalation in mice
  JOURNAL   Pharmacol Biochem Behav 231, 173633 (2023)
   PUBMED   37716413
  REMARK    GeneRIF: FABP5 is important for cognitive function and is an
            important regulator of the physiological effects and
            pharmacokinetics of acute Delta9 tetrahydrocannabinol inhalation in
            mice.
REFERENCE   2  (residues 1 to 134)
  AUTHORS   Chen Z, He C, Gao Z, Li Y, He Q, Wang Y and Cai C.
  TITLE     Polypyrimidine tract binding protein 1 exacerbates cardiac fibrosis
            by regulating fatty acid-binding protein 5
  JOURNAL   ESC Heart Fail 10 (3), 1677-1688 (2023)
   PUBMED   36788730
  REMARK    GeneRIF: Polypyrimidine tract binding protein 1 exacerbates cardiac
            fibrosis by regulating fatty acid-binding protein 5.
REFERENCE   3  (residues 1 to 134)
  AUTHORS   Guo Q, Kawahata I, Cheng A, Wang H, Jia W, Yoshino H and Fukunaga
            K.
  TITLE     Fatty acid-binding proteins 3 and 5 are involved in the initiation
            of mitochondrial damage in ischemic neurons
  JOURNAL   Redox Biol 59, 102547 (2023)
   PUBMED   36481733
  REMARK    GeneRIF: Fatty acid-binding proteins 3 and 5 are involved in the
            initiation of mitochondrial damage in ischemic neurons.
REFERENCE   4  (residues 1 to 134)
  AUTHORS   Reynolds JM, Liu Q, Brittingham KC, Liu Y, Gruenthal M, Gorgun CZ,
            Hotamisligil GS, Stout RD and Suttles J.
  TITLE     Deficiency of fatty acid-binding proteins in mice confers
            protection from development of experimental autoimmune
            encephalomyelitis
  JOURNAL   J Immunol 179 (1), 313-321 (2007)
   PUBMED   17579051
  REMARK    GeneRIF: Metabolic-inflammatory pathway cross-regulation by
            epidermal-type FABP contributes to adaptive immune responses and
            subsequent autoimmune inflammation.
REFERENCE   5  (residues 1 to 134)
  AUTHORS   Maeda K, Cao H, Kono K, Gorgun CZ, Furuhashi M, Uysal KT, Cao Q,
            Atsumi G, Malone H, Krishnan B, Minokoshi Y, Kahn BB, Parker RA and
            Hotamisligil GS.
  TITLE     Adipocyte/macrophage fatty acid binding proteins control integrated
            metabolic responses in obesity and diabetes
  JOURNAL   Cell Metab 1 (2), 107-119 (2005)
   PUBMED   16054052
REFERENCE   6  (residues 1 to 134)
  AUTHORS   Owada Y, Suzuki R, Iwasa H, Spener F and Kondo H.
  TITLE     Localization of epidermal-type fatty acid binding protein in the
            thymic epithelial cells of mice
  JOURNAL   Histochem Cell Biol 117 (1), 55-60 (2002)
   PUBMED   11819097
REFERENCE   7  (residues 1 to 134)
  AUTHORS   Yanase H, Shimizu H, Kanda T, Fujii H and Iwanaga T.
  TITLE     Cellular localization of the diazepam binding inhibitor (DBI) in
            the gastrointestinal tract of mice and its coexistence with the
            fatty acid binding protein (FABP)
  JOURNAL   Arch Histol Cytol 64 (4), 449-460 (2001)
   PUBMED   11757913
REFERENCE   8  (residues 1 to 134)
  AUTHORS   Hertzel AV and Bernlohr DA.
  TITLE     Cloning and chromosomal location of the murine keratinocyte
            lipid-binding protein gene
  JOURNAL   Gene 221 (2), 235-243 (1998)
   PUBMED   9795232
REFERENCE   9  (residues 1 to 134)
  AUTHORS   Bleck B, Hohoff C, Binas B, Rustow B, Dixkens C, Hameister H,
            Borchers T and Spener F.
  TITLE     Cloning and chromosomal localisation of the murine epidermal-type
            fatty acid binding protein gene (Fabpe)
  JOURNAL   Gene 215 (1), 123-130 (1998)
   PUBMED   9666100
REFERENCE   10 (residues 1 to 134)
  AUTHORS   Krieg P, Feil S, Furstenberger G and Bowden GT.
  TITLE     Tumor-specific overexpression of a novel keratinocyte lipid-binding
            protein. Identification and characterization of a cloned sequence
            activated during multistage carcinogenesis in mouse skin
  JOURNAL   J Biol Chem 268 (23), 17362-17369 (1993)
   PUBMED   8349619
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC157379.7.
            
            Summary: The protein encoded by this gene is part of the fatty acid
            binding protein family (FABP). FABPs are a family of small, highly
            conserved, cytoplasmic proteins that bind long-chain fatty acids
            and other hydrophobic ligands and participate in fatty acid uptake,
            transport, and metabolism. In humans this gene has been associated
            with psoriasis and type 2 diabetes. In mouse deficiency of this
            gene in combination with a deficiency in Fabp4 confers protection
            against atherosclerosis, diet-induced obesity, insulin resistance
            and experimental autoimmune encephalomyelitis (the mouse model for
            multiple sclerosis). Alternative splicing results in multiple
            transcript variants that encode different protein isoforms. The
            mouse genome contains many pseudogenes similar to this locus.
            [provided by RefSeq, Jan 2013].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            acceptor splice site in the 3' coding region, compared to variant
            1. This results in a shorter protein (by one amino acid; isoform
            2), compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AV451451.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..134
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 2.47 cM"
     Protein         1..134
                     /product="fatty acid-binding protein 5 isoform 2"
                     /note="fatty acid-binding protein, epidermal; epithelial
                     fatty acid-binding protein; keratinocyte lipid-binding
                     protein; epidermal-type fatty acid-binding protein;
                     psoriasis-associated fatty acid-binding protein homolog"
                     /calculated_mol_wt=14877
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:Q01469; propagated from
                     UniProtKB/Swiss-Prot (Q05816.3)"
     Site            3
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P55053; propagated from
                     UniProtKB/Swiss-Prot (Q05816.3)"
     Region          6..132
                     /region_name="FABP5"
                     /note="fatty acid binding protein 5; cd19468"
                     /db_xref="CDD:381243"
     Site            order(7,19,22..23,26,28,32..33,35..36,39,41,43,45,52,54,
                     56,58,60..61,63..65,67,75..79,81,94,96,107,109,116,118,
                     119,128,130)
                     /site_type="other"
                     /note="ligand binding cavity [chemical binding]"
                     /db_xref="CDD:381243"
     Site            order(22..23,26,32,36,41,56,60..61,78..79,107,118,119,128,
                     130)
                     /site_type="other"
                     /note="endocannabinoid binding site [chemical binding]"
                     /db_xref="CDD:381243"
     Region          24..34
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000250|UniProtKB:Q01469"
                     /note="propagated from UniProtKB/Swiss-Prot (Q05816.3)"
     Site            130
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q01469; propagated from
                     UniProtKB/Swiss-Prot (Q05816.3)"
     CDS             1..134
                     /gene="Fabp5"
                     /gene_synonym="E-FABP; Fabpe; Klbp; mal1; PA-FABP"
                     /coded_by="NM_001272097.1:56..460"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="GeneID:16592"
                     /db_xref="MGI:MGI:101790"
ORIGIN      
        1 maslkdlegk wrlmeshgfe eymkelgvgl alrkmaamak pdciitcdgn nitvktestv
       61 kttvfscnlg ekfdettadg rktetvctfq dgalvqhqqw dgkestitrk lkdgkmivcv
      121 mnnatctrvy ekvq
//
LOCUS       NP_001394518             390 aa            linear   ROD 09-OCT-2023
DEFINITION  mitogen-activated protein kinase 10 isoform 11 [Mus musculus].
ACCESSION   NP_001394518 XP_030110378
VERSION     NP_001394518.1
DBSOURCE    REFSEQ: accession NM_001407589.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 390)
  AUTHORS   Priego M, Noriega L, Kalinin S, Hoffman LM, Feinstein DL and
            Morfini G.
  TITLE     Genetic deletion of c-Jun amino-terminal kinase 3 (JNK3) modestly
            increases disease severity in a mouse model of multiple sclerosis
  JOURNAL   J Neuroimmunol 382, 578152 (2023)
   PUBMED   37454525
  REMARK    GeneRIF: Genetic deletion of c-Jun amino-terminal kinase 3 (JNK3)
            modestly increases disease severity in a mouse model of multiple
            sclerosis.
REFERENCE   2  (residues 1 to 390)
  AUTHORS   Liu F, Deng Y, Zhao Y, Li Z, Gao J, Zhang Y, Yang X, Liu Y and Xia
            Y.
  TITLE     Time series RNA-seq analysis identifies MAPK10 as a critical gene
            in diabetes mellitus-induced atrial fibrillation in mice
  JOURNAL   J Mol Cell Cardiol 168, 70-82 (2022)
   PUBMED   35489387
  REMARK    GeneRIF: Time series RNA-seq analysis identifies MAPK10 as a
            critical gene in diabetes mellitus-induced atrial fibrillation in
            mice.
REFERENCE   3  (residues 1 to 390)
  AUTHORS   Cunningham JG, Scripter JD, Nti SA and Tucker ES.
  TITLE     Early construction of the thalamocortical axon pathway requires
            c-Jun N-terminal kinase signaling within the ventral forebrain
  JOURNAL   Dev Dyn 251 (3), 459-480 (2022)
   PUBMED   34494344
REFERENCE   4  (residues 1 to 390)
  AUTHORS   Goodwani S, Fernandez C, Acton PJ, Buggia-Prevot V, McReynolds ML,
            Ma J, Hu CH, Hamby ME, Jiang Y, Le K, Soth MJ, Jones P and Ray WJ.
  TITLE     Dual Leucine Zipper Kinase Is Constitutively Active in the Adult
            Mouse Brain and Has Both Stress-Induced and Homeostatic Functions
  JOURNAL   Int J Mol Sci 21 (14), 4849 (2020)
   PUBMED   32659913
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 390)
  AUTHORS   Loughran G, Chou MY, Ivanov IP, Jungreis I, Kellis M, Kiran AM,
            Baranov PV and Atkins JF.
  TITLE     Evidence of efficient stop codon readthrough in four mammalian
            genes
  JOURNAL   Nucleic Acids Res 42 (14), 8928-8938 (2014)
   PUBMED   25013167
REFERENCE   6  (residues 1 to 390)
  AUTHORS   Beier H and Grimm M.
  TITLE     Misreading of termination codons in eukaryotes by natural nonsense
            suppressor tRNAs
  JOURNAL   Nucleic Acids Res 29 (23), 4767-4782 (2001)
   PUBMED   11726686
  REMARK    Review article
REFERENCE   7  (residues 1 to 390)
  AUTHORS   Yang DD, Kuan CY, Whitmarsh AJ, Rincon M, Zheng TS, Davis RJ, Rakic
            P and Flavell RA.
  TITLE     Absence of excitotoxicity-induced apoptosis in the hippocampus of
            mice lacking the Jnk3 gene
  JOURNAL   Nature 389 (6653), 865-870 (1997)
   PUBMED   9349820
REFERENCE   8  (residues 1 to 390)
  AUTHORS   Casanova E, Garate C, Ovalle S, Calvo P and Chinchetru MA.
  TITLE     Identification of four splice variants of the mouse
            stress-activated protein kinase JNK/SAPK alpha-isoform
  JOURNAL   Neuroreport 7 (7), 1320-1324 (1996)
   PUBMED   8817558
REFERENCE   9  (residues 1 to 390)
  AUTHORS   Martin JH, Mohit AA and Miller CA.
  TITLE     Developmental expression in the mouse nervous system of the p493F12
            SAP kinase
  JOURNAL   Brain Res Mol Brain Res 35 (1-2), 47-57 (1996)
   PUBMED   8717339
REFERENCE   10 (residues 1 to 390)
  AUTHORS   Suzuki J, Yoshida S, Chen ZL, Momota Y, Kato K, Hirata A and
            Shiosaka S.
  TITLE     Ontogeny of neuropsin mRNA expression in the mouse brain
  JOURNAL   Neurosci Res 23 (4), 345-351 (1995)
   PUBMED   8602273
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC123664.15, AC137121.9 and
            AC125252.7.
            
            On Jun 6, 2022 this sequence version replaced XP_030110378.1.
            
            Summary: The protein encoded by this gene is a member of the MAP
            kinase family. MAP kinases act as integration points for multiple
            biochemical signals, and thus are involved in a wide variety of
            cellular processes, such as proliferation, differentiation,
            transcription regulation and development. This kinase is
            specifically expressed in a subset of neurons in the nervous system
            and is activated by threonine and tyrosine phosphorylation.
            Targeted deletion of this gene in mice suggests that it may have a
            role in stress-induced neuronal apoptosis. Alternatively spliced
            transcript variants encoding different isoforms have been found for
            this gene. A recent study provided evidence for translational
            readthrough in this gene, and expression of an additional
            C-terminally extended isoform via the use of an alternative
            in-frame translation termination codon. [provided by RefSeq, Dec
            2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849376
                              [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..390
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 49.61 cM"
     Protein         1..390
                     /product="mitogen-activated protein kinase 10 isoform 11"
                     /EC_number="2.7.11.24"
                     /note="JNK3 beta1 protein kinase; JNK3 beta2 protein
                     kinase; MAP kinase 10; MAP kinase p49 3F12; c-Jun
                     N-terminal kinase 3; stress-activated protein kinase JNK3;
                     SAPK/Erk/kinase 2"
                     /calculated_mol_wt=43909
     Region          6..324
                     /region_name="STKc_JNK"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     c-Jun N-terminal Kinase; cd07850"
                     /db_xref="CDD:270840"
     Site            order(36,80,115,117,136,147,149..152,154,191)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270840"
     Site            order(76,82,91,94,123..127,287..288,290,293)
                     /site_type="other"
                     /note="KIM docking site [polypeptide binding]"
                     /db_xref="CDD:270840"
     Site            order(132..142,146..154)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270840"
     CDS             1..390
                     /gene="Mapk10"
                     /gene_synonym="C230008H04Rik; JNK3; JNK3B1; JNK3B2;
                     p493F12; p54bSAPK; SAPK(beta); Serk2"
                     /coded_by="NM_001407589.1:226..1398"
                     /note="isoform 11 is encoded by transcript variant 19"
                     /db_xref="GeneID:26414"
                     /db_xref="MGI:MGI:1346863"
ORIGIN      
        1 mntwsaayda vldrnvaikk lsrpfqnqth akrayrelvl mkcvnhknii sllnvftpqk
       61 tleefqdvyl vmelmdanlc qviqmeldhe rmsyllyqml cgikhlhsag iihrdlkpsn
      121 ivvksdctlk ildfglarta gtsfmmtpyv vtryyrapev ilgmgykenv dlwsvgcimg
      181 emvkgtvlfp gtdhidqwnk vieqlgtpcp efmkklqptv rnyvenrpky agltfpklfp
      241 dslfpadseh nklkasqard llskmlvidp akrisvddal qhpyinvwyd paeveapppq
      301 iydkqldere htieewkeli ykevmnseek tkngvvkgqp spsgaavnss eslppsssvn
      361 dissmstdqt lasdtdssle asagplgccr
//
LOCUS       NP_034631                403 aa            linear   ROD 09-OCT-2023
DEFINITION  interferon-induced protein with tetratricopeptide repeats 3 [Mus
            musculus].
ACCESSION   NP_034631
VERSION     NP_034631.1
DBSOURCE    REFSEQ: accession NM_010501.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 403)
  AUTHORS   Lu YJ, Deng YT, Ko HH, Peng HH, Lee HC, Kuo MY and Cheng SJ.
  TITLE     Lysyl oxidase-like 2 promotes stemness and enhances antitumor
            effects of gefitinib in head and neck cancer via IFIT1 and IFIT3
  JOURNAL   Cancer Sci 114 (10), 3957-3971 (2023)
   PUBMED   37496288
  REMARK    GeneRIF: Lysyl oxidase-like 2 promotes stemness and enhances
            antitumor effects of gefitinib in head and neck cancer via IFIT1
            and IFIT3.
REFERENCE   2  (residues 1 to 403)
  AUTHORS   Aditi, Downing SM, Schreiner PA, Kwak YD, Li Y, Shaw TI, Russell HR
            and McKinnon PJ.
  TITLE     Genome instability independent of type I interferon signaling
            drives neuropathology caused by impaired ribonucleotide excision
            repair
  JOURNAL   Neuron 109 (24), 3962-3979 (2021)
   PUBMED   34655526
REFERENCE   3  (residues 1 to 403)
  AUTHORS   Sun J, Zhang Q, Liu X and Shang X.
  TITLE     Downregulation of interferon-induced protein with tetratricopeptide
            repeats 3 relieves the inflammatory response and myocardial
            fibrosis of mice with myocardial infarction and improves their
            cardiac function
  JOURNAL   Exp Anim 70 (4), 522-531 (2021)
   PUBMED   34234081
  REMARK    GeneRIF: Downregulation of interferon-induced protein with
            tetratricopeptide repeats 3 relieves the inflammatory response and
            myocardial fibrosis of mice with myocardial infarction and improves
            their cardiac function.
REFERENCE   4  (residues 1 to 403)
  AUTHORS   Chai B, Tian D, Zhou M, Tian B, Yuan Y, Sui B, Wang K, Pei J, Huang
            F, Wu Q, Lv L, Yang Y, Wang C, Fu Z and Zhao L.
  TITLE     Murine Ifit3 restricts the replication of Rabies virus both in
            vitro and in vivo
  JOURNAL   J Gen Virol 102 (7) (2021)
   PUBMED   34269675
  REMARK    GeneRIF: Murine Ifit3 restricts the replication of Rabies virus
            both in vitro and in vivo.
REFERENCE   5  (residues 1 to 403)
  AUTHORS   Uehara R, Cerritelli SM, Hasin N, Sakhuja K, London M, Iranzo J,
            Chon H, Grinberg A and Crouch RJ.
  TITLE     Two RNase H2 Mutants with Differential rNMP Processing Activity
            Reveal a Threshold of Ribonucleotide Tolerance for Embryonic
            Development
  JOURNAL   Cell Rep 25 (5), 1135-1145 (2018)
   PUBMED   30380406
REFERENCE   6  (residues 1 to 403)
  AUTHORS   Wacher C, Muller M, Hofer MJ, Getts DR, Zabaras R, Ousman SS,
            Terenzi F, Sen GC, King NJ and Campbell IL.
  TITLE     Coordinated regulation and widespread cellular expression of
            interferon-stimulated genes (ISG) ISG-49, ISG-54, and ISG-56 in the
            central nervous system after infection with distinct viruses
  JOURNAL   J Virol 81 (2), 860-871 (2007)
   PUBMED   17079283
  REMARK    GeneRIF: Expression increased significantly during LCMV and WNV
            infection, being widespread and localized predominantly to common
            as well as distinct neuronal populations in the brain.
REFERENCE   7  (residues 1 to 403)
  AUTHORS   Yoshida H, Okabe Y, Kawane K, Fukuyama H and Nagata S.
  TITLE     Lethal anemia caused by interferon-beta produced in mouse embryos
            carrying undigested DNA
  JOURNAL   Nat Immunol 6 (1), 49-56 (2005)
   PUBMED   15568025
REFERENCE   8  (residues 1 to 403)
  AUTHORS   Smith JB and Herschman HR.
  TITLE     The glucocorticoid attenuated response genes GARG-16, GARG-39, and
            GARG-49/IRG2 encode inducible proteins containing multiple
            tetratricopeptide repeat domains
  JOURNAL   Arch Biochem Biophys 330 (2), 290-300 (1996)
   PUBMED   8660659
REFERENCE   9  (residues 1 to 403)
  AUTHORS   Smith JB and Herschman HR.
  TITLE     Glucocorticoid-attenuated response genes encode intercellular
            mediators, including a new C-X-C chemokine
  JOURNAL   J Biol Chem 270 (28), 16756-16765 (1995)
   PUBMED   7622488
REFERENCE   10 (residues 1 to 403)
  AUTHORS   Lee CG, Demarquoy J, Jackson MJ and O'Brien WE.
  TITLE     Molecular cloning and characterization of a murine LPS-inducible
            cDNA
  JOURNAL   J Immunol 152 (12), 5758-5767 (1994)
   PUBMED   8207206
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK153226.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK077459.1, AK153226.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..403
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 29.74 cM"
     Protein         1..403
                     /product="interferon-induced protein with
                     tetratricopeptide repeats 3"
                     /note="IRG2; IFIT-3; GARG-49; glucocorticoid-attenuated
                     response gene 49 protein"
                     /calculated_mol_wt=47092
     Region          51..126
                     /region_name="TPR_12"
                     /note="Tetratricopeptide repeat; pfam13424"
                     /db_xref="CDD:315987"
     Region          51..79
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          <56..>300
                     /region_name="PEP_TPR_lipo"
                     /note="putative PEP-CTERM system TPR-repeat lipoprotein;
                     TIGR02917"
                     /db_xref="CDD:274350"
     Region          84..123
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          94..127
                     /region_name="TPR 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64345.1)"
     Region          136..169
                     /region_name="TPR 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64345.1)"
     Region          136..164
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(137,140..141,144..145,147,171,174..175,178..179,
                     181..182,242,245..246,249..250,253)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          169..202
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          172..206
                     /region_name="TPR 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64345.1)"
     Region          241..274
                     /region_name="TPR 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64345.1)"
     Region          241..269
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..403
                     /gene="Ifit3"
                     /gene_synonym="Ifi49; P49"
                     /coded_by="NM_010501.2:72..1283"
                     /db_xref="CCDS:CCDS29762.1"
                     /db_xref="GeneID:15959"
                     /db_xref="MGI:MGI:1101055"
ORIGIN      
        1 msevnresle ailpqlkchf twnlfregsm sshmedrvcn qvehlnseek atmydllayi
       61 khldgeskaa leclgqaedl rksehndqse irrlvtwgny awiyyhmgrl seaqayvdkv
      121 rqvcqkfanp ysmecpelec eegwtrlkcg rnerakmcfe kaleekpkdp ecssgmaiam
      181 frleekpekq fsvdalkqam elnpqnqylk vllalkllrm geeaegerli kdalgkapnq
      241 tdvlqkaaqf ykkkgnldra iellgkalrs tvnnsplysl vmcryreile qlqnkgdads
      301 serrqrmael rrltmefmqk tlqrrrspln sysdlidfpe vercyqmvis kespdveeed
      361 lyerycnlqe yhrksedlaa lecllqfprn ersiekeevk eqt
//
LOCUS       NP_001351359             129 aa            linear   ROD 09-OCT-2023
DEFINITION  pro-neuregulin-1, membrane-bound isoform isoform 11 precursor [Mus
            musculus].
ACCESSION   NP_001351359
VERSION     NP_001351359.1
DBSOURCE    REFSEQ: accession NM_001364430.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 129)
  AUTHORS   Mikami Y, Iwase F, Ohshima D, Tomida T and Adachi-Akahane S.
  TITLE     Compensatory role of neuregulin-1 in diabetic cardiomyopathy
  JOURNAL   J Pharmacol Sci 153 (3), 130-141 (2023)
   PUBMED   37770154
  REMARK    GeneRIF: Compensatory role of neuregulin-1 in diabetic
            cardiomyopathy.
REFERENCE   2  (residues 1 to 129)
  AUTHORS   Qiao XY, Wang Y, Zhang W, Li Q, Liu C, Dao JJ, Qiao CM, Cui C, Shen
            YQ and Zhao WJ.
  TITLE     Involvement of CXCL10 in Neuronal Damage under the Condition of
            Spinal Cord Injury and the Potential Therapeutic Effect of Nrg1
  JOURNAL   J Integr Neurosci 22 (4), 96 (2023)
   PUBMED   37519170
  REMARK    GeneRIF: Involvement of CXCL10 in Neuronal Damage under the
            Condition of Spinal Cord Injury and the Potential Therapeutic
            Effect of Nrg1.
REFERENCE   3  (residues 1 to 129)
  AUTHORS   Liu H, Lu P, He S, Luo Y, Fang Y, Benkaci S, Wu B, Wang Y and Zhou
            B.
  TITLE     beta-Catenin regulates endocardial cushion growth by suppressing
            p21
  JOURNAL   Life Sci Alliance 6 (9), e202302163 (2023)
   PUBMED   37385754
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 129)
  AUTHORS   Kong L, Hassinan CW, Gerstner F, Buettner JM, Petigrow JB, Valdivia
            DO, Chan-Cortes MH, Mistri A, Cao A, McGaugh SA, Denton M, Brown S,
            Ross J, Schwab MH, Simon CM and Sumner CJ.
  TITLE     Boosting neuregulin 1 type-III expression hastens SMA motor axon
            maturation
  JOURNAL   Acta Neuropathol Commun 11 (1), 53 (2023)
   PUBMED   36997967
  REMARK    GeneRIF: Boosting neuregulin 1 type-III expression hastens SMA
            motor axon maturation.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 129)
  AUTHORS   Zhang X, Xiao G, Johnson C, Cai Y, Horowitz ZK, Mennicke C, Coffey
            R, Haider M, Threadgill D, Eliscu R, Oldham MC, Greenbaum A and
            Ghashghaei HT.
  TITLE     Bulk and mosaic deletions of Egfr reveal regionally defined
            gliogenesis in the developing mouse forebrain
  JOURNAL   iScience 26 (3), 106242 (2023)
   PUBMED   36915679
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 129)
  AUTHORS   Gassmann M, Casagranda F, Orioli D, Simon H, Lai C, Klein R and
            Lemke G.
  TITLE     Aberrant neural and cardiac development in mice lacking the ErbB4
            neuregulin receptor
  JOURNAL   Nature 378 (6555), 390-394 (1995)
   PUBMED   7477376
REFERENCE   7  (residues 1 to 129)
  AUTHORS   Meyer,D. and Birchmeier,C.
  TITLE     Multiple essential functions of neuregulin in development
  JOURNAL   Nature 378 (6555), 386-390 (1995)
   PUBMED   7477375
  REMARK    Erratum:[Nature 1995 Dec 14;378(6558):753]
REFERENCE   8  (residues 1 to 129)
  AUTHORS   Moscoso LM, Chu GC, Gautam M, Noakes PG, Merlie JP and Sanes JR.
  TITLE     Synapse-associated expression of an acetylcholine receptor-inducing
            protein, ARIA/heregulin, and its putative receptors, ErbB2 and
            ErbB3, in developing mammalian muscle
  JOURNAL   Dev Biol 172 (1), 158-169 (1995)
   PUBMED   7589796
REFERENCE   9  (residues 1 to 129)
  AUTHORS   Yang Y, Spitzer E, Meyer D, Sachs M, Niemann C, Hartmann G, Weidner
            KM, Birchmeier C and Birchmeier W.
  TITLE     Sequential requirement of hepatocyte growth factor and neuregulin
            in the morphogenesis and differentiation of the mammary gland
  JOURNAL   J Cell Biol 131 (1), 215-226 (1995)
   PUBMED   7559778
REFERENCE   10 (residues 1 to 129)
  AUTHORS   Ho WH, Armanini MP, Nuijens A, Phillips HS and Osheroff PL.
  TITLE     Sensory and motor neuron-derived factor. A novel heregulin variant
            highly expressed in sensory and motor neurons
  JOURNAL   J Biol Chem 270 (24), 14523-14532 (1995)
   PUBMED   7782315
  REMARK    Erratum:[J Biol Chem. 1995 Nov 3;270(44):26722. PMID: 7592900]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132407.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AA798243.1, SRR13861889.87879.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..129
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 18.75 cM"
     Protein         1..129
                     /product="pro-neuregulin-1, membrane-bound isoform isoform
                     11 precursor"
                     /note="heregulin; type III neuregulin 1; type I neuregulin
                     1; pro-neuregulin-1, membrane-bound isoform"
                     /calculated_mol_wt=11205
     sig_peptide     1..26
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=2841
     CDS             1..129
                     /gene="Nrg1"
                     /gene_synonym="6030402G23Rik; ARIA; D230005F13Rik; GGF;
                     GGFII; Hgl; HRG; HRGalpha; NDF; Pro-NRG1; SMDF"
                     /coded_by="NM_001364430.1:39..428"
                     /note="isoform 11 precursor is encoded by transcript
                     variant 11"
                     /db_xref="GeneID:211323"
                     /db_xref="MGI:MGI:96083"
ORIGIN      
        1 mapapsllhy piivchllff adlttgmsas terpyvsses pirisvsteg antssststs
       61 ttgtshlikc aekektfcvn ggecfmvkdl snpsrylckc pneftgdrcq nyvmasfyst
      121 stpflslpe
//
LOCUS       NP_001349263             448 aa            linear   ROD 09-OCT-2023
DEFINITION  CUGBP Elav-like family member 4 isoform 52 [Mus musculus].
ACCESSION   NP_001349263
VERSION     NP_001349263.1
DBSOURCE    REFSEQ: accession NM_001362334.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 448)
  AUTHORS   Salamon I, Park Y, Miskic T, Kopic J, Matteson P, Page NF, Roque A,
            McAuliffe GW, Favate J, Garcia-Forn M, Shah P, Judas M, Millonig
            JH, Kostovic I, De Rubeis S, Hart RP, Krsnik Z and Rasin MR.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    GeneRIF: Celf4 controls mRNA translation underlying synaptic
            development in the prenatal mammalian neocortex.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 448)
  AUTHORS   Shen Y, Zhang C, Xiao K, Liu D and Xie G.
  TITLE     CELF4 regulates spine formation and depression-like behaviors of
            mice
  JOURNAL   Biochem Biophys Res Commun 605, 39-44 (2022)
   PUBMED   35306363
  REMARK    GeneRIF: CELF4 regulates spine formation and depression-like
            behaviors of mice.
REFERENCE   3  (residues 1 to 448)
  AUTHORS   Moreau MX, Saillour Y, Cwetsch AW, Pierani A and Causeret F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   4  (residues 1 to 448)
  AUTHORS   Li C, Li X, Bi Z, Sugino K, Wang G, Zhu T and Liu Z.
  TITLE     Comprehensive transcriptome analysis of cochlear spiral ganglion
            neurons at multiple ages
  JOURNAL   Elife 9, e50491 (2020)
   PUBMED   31913118
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 448)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 448)
  AUTHORS   Ladd AN, Taffet G, Hartley C, Kearney DL and Cooper TA.
  TITLE     Cardiac tissue-specific repression of CELF activity disrupts
            alternative splicing and causes cardiomyopathy
  JOURNAL   Mol Cell Biol 25 (14), 6267-6278 (2005)
   PUBMED   15988035
  REMARK    GeneRIF: CELF protein activity is required for normal alternative
            splicing in the heart in vivo and normal CELF-mediated alternative
            splicing regulation is in turn required for normal cardiac
            function.
REFERENCE   7  (residues 1 to 448)
  AUTHORS   Meins M, Schlickum S, Wilhelm C, Missbach J, Yadav S, Glaser B,
            Grzmil M, Burfeind P and Laccone F.
  TITLE     Identification and characterization of murine Brunol4, a new member
            of the elav/bruno family
  JOURNAL   Cytogenet Genome Res 97 (3-4), 254-260 (2002)
   PUBMED   12438720
  REMARK    GeneRIF: cloning and characterization
REFERENCE   8  (residues 1 to 448)
  AUTHORS   Ladd AN, Charlet N and Cooper TA.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   9  (residues 1 to 448)
  AUTHORS   Good PJ, Chen Q, Warner SJ and Herring DC.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
REFERENCE   10 (residues 1 to 448)
  AUTHORS   Yulug IG, Egan SE, See CG and Fisher EM.
  TITLE     Mapping GRB2, a signal transduction gene in the human and the mouse
  JOURNAL   Genomics 22 (2), 313-318 (1994)
   PUBMED   7806216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121094.8 and AC144938.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.98055.1,
                                           SRR10662772.1704143.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..448
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 13.92 cM"
     Protein         1..448
                     /product="CUGBP Elav-like family member 4 isoform 52"
                     /note="CUG-BP- and ETR-3-like factor 4; bruno-like protein
                     4; RNA-binding protein BRUNOL-4; bruno-like 4, RNA binding
                     protein"
                     /calculated_mol_wt=47581
     Region          49..135
                     /region_name="RRM1_CELF3_4_5_6"
                     /note="RNA recognition motif 1 (RRM1) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12632"
                     /db_xref="CDD:410041"
     Site            order(55,57,59..60,63,82,84,86,95..97,99,129,131)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410041"
     Region          56..444
                     /region_name="ELAV_HUD_SF"
                     /note="ELAV/HuD family splicing factor; TIGR01661"
                     /db_xref="CDD:273741"
     Region          142..222
                     /region_name="RRM2_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12635"
                     /db_xref="CDD:410043"
     Site            order(144,146,148..149,152,171,173,175,183..185,187,217,
                     219)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410043"
     CDS             1..448
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /coded_by="NM_001362334.1:531..1877"
                     /note="isoform 52 is encoded by transcript variant 53"
                     /db_xref="GeneID:108013"
                     /db_xref="MGI:MGI:1932407"
ORIGIN      
        1 myikmatlan gqadnaslst nglgsspgsa ghmnglshsp gnpstipmkd hdaiklfigq
       61 iprnldekdl kplfeefgki yeltvlkdrf tgmhkgcafl tyceresalk aqsalheqkt
      121 lpgmnrpiqv kpadsesrgg kdrklfvgml nkqqseddvr rlfeafgnie ectilrgpdg
      181 nskgcafvky sshaeaqaai nalhgsqtmp gassslvvkf adtdkertmr rmqqmagqmg
      241 mfnpmaipfg aygayaqalm qqqaalmasv aqggylnpma afaaaqmqqm aalnmnglaa
      301 apmtptsggs tppgitapav psipspigvn gftglppqan gqpaaeavfa ngihpypaqs
      361 ptaadplqqa yagvqqyagp aypaaygqis qafpqpppmi pqqqregfvs fdnpasaqta
      421 iqamngfqig mkrlkvqlkr pkdanrpy
//
LOCUS       NP_001394529             178 aa            linear   ROD 09-OCT-2023
DEFINITION  mitogen-activated protein kinase 10 isoform 13 [Mus musculus].
ACCESSION   NP_001394529
VERSION     NP_001394529.1
DBSOURCE    REFSEQ: accession NM_001407600.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 178)
  AUTHORS   Priego M, Noriega L, Kalinin S, Hoffman LM, Feinstein DL and
            Morfini G.
  TITLE     Genetic deletion of c-Jun amino-terminal kinase 3 (JNK3) modestly
            increases disease severity in a mouse model of multiple sclerosis
  JOURNAL   J Neuroimmunol 382, 578152 (2023)
   PUBMED   37454525
  REMARK    GeneRIF: Genetic deletion of c-Jun amino-terminal kinase 3 (JNK3)
            modestly increases disease severity in a mouse model of multiple
            sclerosis.
REFERENCE   2  (residues 1 to 178)
  AUTHORS   Liu F, Deng Y, Zhao Y, Li Z, Gao J, Zhang Y, Yang X, Liu Y and Xia
            Y.
  TITLE     Time series RNA-seq analysis identifies MAPK10 as a critical gene
            in diabetes mellitus-induced atrial fibrillation in mice
  JOURNAL   J Mol Cell Cardiol 168, 70-82 (2022)
   PUBMED   35489387
  REMARK    GeneRIF: Time series RNA-seq analysis identifies MAPK10 as a
            critical gene in diabetes mellitus-induced atrial fibrillation in
            mice.
REFERENCE   3  (residues 1 to 178)
  AUTHORS   Cunningham JG, Scripter JD, Nti SA and Tucker ES.
  TITLE     Early construction of the thalamocortical axon pathway requires
            c-Jun N-terminal kinase signaling within the ventral forebrain
  JOURNAL   Dev Dyn 251 (3), 459-480 (2022)
   PUBMED   34494344
REFERENCE   4  (residues 1 to 178)
  AUTHORS   Goodwani S, Fernandez C, Acton PJ, Buggia-Prevot V, McReynolds ML,
            Ma J, Hu CH, Hamby ME, Jiang Y, Le K, Soth MJ, Jones P and Ray WJ.
  TITLE     Dual Leucine Zipper Kinase Is Constitutively Active in the Adult
            Mouse Brain and Has Both Stress-Induced and Homeostatic Functions
  JOURNAL   Int J Mol Sci 21 (14), 4849 (2020)
   PUBMED   32659913
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 178)
  AUTHORS   Loughran G, Chou MY, Ivanov IP, Jungreis I, Kellis M, Kiran AM,
            Baranov PV and Atkins JF.
  TITLE     Evidence of efficient stop codon readthrough in four mammalian
            genes
  JOURNAL   Nucleic Acids Res 42 (14), 8928-8938 (2014)
   PUBMED   25013167
REFERENCE   6  (residues 1 to 178)
  AUTHORS   Beier H and Grimm M.
  TITLE     Misreading of termination codons in eukaryotes by natural nonsense
            suppressor tRNAs
  JOURNAL   Nucleic Acids Res 29 (23), 4767-4782 (2001)
   PUBMED   11726686
  REMARK    Review article
REFERENCE   7  (residues 1 to 178)
  AUTHORS   Yang DD, Kuan CY, Whitmarsh AJ, Rincon M, Zheng TS, Davis RJ, Rakic
            P and Flavell RA.
  TITLE     Absence of excitotoxicity-induced apoptosis in the hippocampus of
            mice lacking the Jnk3 gene
  JOURNAL   Nature 389 (6653), 865-870 (1997)
   PUBMED   9349820
REFERENCE   8  (residues 1 to 178)
  AUTHORS   Casanova E, Garate C, Ovalle S, Calvo P and Chinchetru MA.
  TITLE     Identification of four splice variants of the mouse
            stress-activated protein kinase JNK/SAPK alpha-isoform
  JOURNAL   Neuroreport 7 (7), 1320-1324 (1996)
   PUBMED   8817558
REFERENCE   9  (residues 1 to 178)
  AUTHORS   Martin JH, Mohit AA and Miller CA.
  TITLE     Developmental expression in the mouse nervous system of the p493F12
            SAP kinase
  JOURNAL   Brain Res Mol Brain Res 35 (1-2), 47-57 (1996)
   PUBMED   8717339
REFERENCE   10 (residues 1 to 178)
  AUTHORS   Suzuki J, Yoshida S, Chen ZL, Momota Y, Kato K, Hirata A and
            Shiosaka S.
  TITLE     Ontogeny of neuropsin mRNA expression in the mouse brain
  JOURNAL   Neurosci Res 23 (4), 345-351 (1995)
   PUBMED   8602273
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC123664.15 and AC137121.9.
            
            Summary: The protein encoded by this gene is a member of the MAP
            kinase family. MAP kinases act as integration points for multiple
            biochemical signals, and thus are involved in a wide variety of
            cellular processes, such as proliferation, differentiation,
            transcription regulation and development. This kinase is
            specifically expressed in a subset of neurons in the nervous system
            and is activated by threonine and tyrosine phosphorylation.
            Targeted deletion of this gene in mice suggests that it may have a
            role in stress-induced neuronal apoptosis. Alternatively spliced
            transcript variants encoding different isoforms have been found for
            this gene. A recent study provided evidence for translational
            readthrough in this gene, and expression of an additional
            C-terminally extended isoform via the use of an alternative
            in-frame translation termination codon. [provided by RefSeq, Dec
            2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK163385.1, BY725991.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849376 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..178
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 49.61 cM"
     Protein         1..178
                     /product="mitogen-activated protein kinase 10 isoform 13"
                     /EC_number="2.7.11.24"
                     /note="JNK3 beta1 protein kinase; JNK3 beta2 protein
                     kinase; MAP kinase 10; MAP kinase p49 3F12; c-Jun
                     N-terminal kinase 3; stress-activated protein kinase JNK3;
                     SAPK/Erk/kinase 2"
                     /calculated_mol_wt=20249
     Region          6..>169
                     /region_name="PKc_like"
                     /note="Protein Kinases, catalytic domain; cl21453"
                     /db_xref="CDD:451246"
     CDS             1..178
                     /gene="Mapk10"
                     /gene_synonym="C230008H04Rik; JNK3; JNK3B1; JNK3B2;
                     p493F12; p54bSAPK; SAPK(beta); Serk2"
                     /coded_by="NM_001407600.1:226..762"
                     /note="isoform 13 is encoded by transcript variant 23"
                     /db_xref="GeneID:26414"
                     /db_xref="MGI:MGI:1346863"
ORIGIN      
        1 mntwsaayda vldrnvaikk lsrpfqnqth akrayrelvl mkcvnhknii sllnvftpqk
       61 tleefqdvyl vmelmdanlc qviqmeldhe rmsyllyqml cgikhlhsag iihrdlkpsn
      121 ivvksdctlk ildfglarta gtsfmmtpyv vtryyrapev ilgmgykeng rdgsgtsi
//
LOCUS       NP_001157010             288 aa            linear   ROD 09-OCT-2023
DEFINITION  serine/threonine-protein phosphatase PGAM5, mitochondrial isoform 1
            [Mus musculus].
ACCESSION   NP_001157010
VERSION     NP_001157010.1
DBSOURCE    REFSEQ: accession NM_001163538.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 288)
  AUTHORS   Cai C, Li Z, Zheng Z, Guo Z, Li Q, Deng S, Shi N, Ou Q, Zhou H, Guo
            Z, Chen Z and Zhu H.
  TITLE     Pgam5-mediated PHB2 dephosphorylation contributes to
            endotoxemia-induced myocardial dysfunction by inhibiting mitophagy
            and the mitochondrial unfolded protein response
  JOURNAL   Int J Biol Sci 19 (14), 4657-4671 (2023)
   PUBMED   37781037
  REMARK    GeneRIF: Pgam5-mediated PHB2 dephosphorylation contributes to
            endotoxemia-induced myocardial dysfunction by inhibiting mitophagy
            and the mitochondrial unfolded protein response.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 288)
  AUTHORS   Dai C, Qu B, Peng B, Liu B, Li Y, Niu C, Peng B and Li D.
  TITLE     Phosphoglycerate mutase 5 facilitates mitochondrial dysfunction and
            neuroinflammation in spinal tissues after spinal cord injury
  JOURNAL   Int Immunopharmacol 116, 109773 (2023)
   PUBMED   36773566
  REMARK    GeneRIF: Phosphoglycerate mutase 5 facilitates mitochondrial
            dysfunction and neuroinflammation in spinal tissues after spinal
            cord injury.
REFERENCE   3  (residues 1 to 288)
  AUTHORS   Li J, Sun X, Yang N, Ni J, Xie H, Guo H, Wang X, Zhou L, Liu J,
            Chen S, Wang X, Zhang Y, Yu C, Zhang W and Lu L.
  TITLE     Phosphoglycerate mutase 5 initiates inflammation in acute kidney
            injury by triggering mitochondrial DNA release by dephosphorylating
            the pro-apoptotic protein Bax
  JOURNAL   Kidney Int 103 (1), 115-133 (2023)
   PUBMED   36089186
  REMARK    GeneRIF: Phosphoglycerate mutase 5 initiates inflammation in acute
            kidney injury by triggering mitochondrial DNA release by
            dephosphorylating the pro-apoptotic protein Bax.
REFERENCE   4  (residues 1 to 288)
  AUTHORS   Denk D, Petrocelli V, Conche C, Drachsler M, Ziegler PK, Braun A,
            Kress A, Nicolas AM, Mohs K, Becker C, Neurath MF, Farin HF,
            Buchholz CJ, Andreux PA, Rinsch C and Greten FR.
  TITLE     Expansion of T memory stem cells with superior anti-tumor immunity
            by Urolithin A-induced mitophagy
  JOURNAL   Immunity 55 (11), 2059-2073 (2022)
   PUBMED   36351375
REFERENCE   5  (residues 1 to 288)
  AUTHORS   Zhu P, Wang J, Du W, Ren J, Zhang Y, Xie F and Xu G.
  TITLE     NR4A1 Promotes LPS-Induced Acute Lung Injury through Inhibition of
            Opa1-Mediated Mitochondrial Fusion and Activation of PGAM5-Related
            Necroptosis
  JOURNAL   Oxid Med Cell Longev 2022, 6638244 (2022)
   PUBMED   35222801
  REMARK    GeneRIF: NR4A1 Promotes LPS-Induced Acute Lung Injury through
            Inhibition of Opa1-Mediated Mitochondrial Fusion and Activation of
            PGAM5-Related Necroptosis.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 288)
  AUTHORS   Kang YJ, Bang BR, Han KH, Hong L, Shim EJ, Ma J, Lerner RA and
            Otsuka M.
  TITLE     Regulation of NKT cell-mediated immune responses to tumours and
            liver inflammation by mitochondrial PGAM5-Drp1 signalling
  JOURNAL   Nat Commun 6, 8371 (2015)
   PUBMED   26381214
  REMARK    GeneRIF: Results identify a crucial role for RIPK3-PGAM5-Drp1/NFAT
            signalling in NKT cell activation, and further suggest that
            RIPK3-PGAM5 signalling may mediate crosstalk between mitochondrial
            function and immune signalling.
            Publication Status: Online-Only
REFERENCE   7  (residues 1 to 288)
  AUTHORS   Lu W, Karuppagounder SS, Springer DA, Allen MD, Zheng L, Chao B,
            Zhang Y, Dawson VL, Dawson TM and Lenardo M.
  TITLE     Genetic deficiency of the mitochondrial protein PGAM5 causes a
            Parkinson's-like movement disorder
  JOURNAL   Nat Commun 5, 4930 (2014)
   PUBMED   25222142
  REMARK    GeneRIF: Loss of PGAM5 disables PINK1-mediated mitophagy in vitro
            and leads to dopaminergic neurodegeneration and mild dopamine loss
            in vivo causing a Parkinson's-like movement disorder.
            Publication Status: Online-Only
REFERENCE   8  (residues 1 to 288)
  AUTHORS   Wilkins JM, McConnell C, Tipton PA and Hannink M.
  TITLE     A conserved motif mediates both multimer formation and allosteric
            activation of phosphoglycerate mutase 5
  JOURNAL   J Biol Chem 289 (36), 25137-25148 (2014)
   PUBMED   25012655
  REMARK    GeneRIF: Data indicate that phosphoglycerate mutase 5 (PGAM5)
            contains an N-terminal WDXNWD motif required for multimerization
            and maximal phosphatase activity.
REFERENCE   9  (residues 1 to 288)
  AUTHORS   Wang Z, Jiang H, Chen S, Du F and Wang X.
  TITLE     The mitochondrial phosphatase PGAM5 functions at the convergence
            point of multiple necrotic death pathways
  JOURNAL   Cell 148 (1-2), 228-243 (2012)
   PUBMED   22265414
  REMARK    GeneRIF: Experimental data indicate that the two splice variants of
            the mitochondrial protein phosphatase PGAM5 are at the convergent
            point of multiple necrosis pathways.
REFERENCE   10 (residues 1 to 288)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY101410.1, BC052179.1 and BY620990.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146216.1, AK169643.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..288
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 53.43 cM"
     Protein         1..288
                     /product="serine/threonine-protein phosphatase PGAM5,
                     mitochondrial isoform 1"
                     /EC_number="3.1.3.16"
                     /note="serine/threonine-protein phosphatase PGAM5,
                     mitochondrial"
                     /calculated_mol_wt=31863
     Site            7..29
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BX10.1)"
     Region          13..286
                     /region_name="HP"
                     /note="Histidine phosphatase domain found in a
                     functionally diverse set of proteins, mostly phosphatases;
                     contains a His residue which is phosphorylated during the
                     reaction; cl11399"
                     /db_xref="CDD:448243"
     Site            24..25
                     /site_type="cleavage"
                     /note="Cleavage, by PARL.
                     /evidence=ECO:0000250|UniProtKB:Q96HS1; propagated from
                     UniProtKB/Swiss-Prot (Q8BX10.1)"
     Region          76..81
                     /region_name="Interaction with KEAP1.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BX10.1)"
     Site            79
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96HS1; propagated from
                     UniProtKB/Swiss-Prot (Q8BX10.1)"
     Site            86
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96HS1; propagated from
                     UniProtKB/Swiss-Prot (Q8BX10.1)"
     Site            order(103..104,151,229..230)
                     /site_type="active"
                     /note="catalytic core [active]"
                     /db_xref="CDD:132718"
     Site            115
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q96HS1; propagated from
                     UniProtKB/Swiss-Prot (Q8BX10.1)"
     Site            143
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q96HS1; propagated from
                     UniProtKB/Swiss-Prot (Q8BX10.1)"
     Site            190
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q96HS1; propagated from
                     UniProtKB/Swiss-Prot (Q8BX10.1)"
     CDS             1..288
                     /gene="Pgam5"
                     /gene_synonym="2610528A17Rik"
                     /coded_by="NM_001163538.1:61..927"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS51606.1"
                     /db_xref="GeneID:72542"
                     /db_xref="MGI:MGI:1919792"
ORIGIN      
        1 mafrqalqla acglaggsaa vlfsavavgk prgggdadtr ateppawtga ragrgvwdtn
       61 wdrreplsli nlkkrnvesg edeltsrldh ykakatrhif lirhsqyhvd gslekdrtlt
      121 plgreqaelt glrlaslglk fnkivhssmt ravettdiis khlpgvsrvs tdllregapi
      181 epdppvshwk peavqyyedg arieaafrny ihradarqee dsyeificha nviryivcra
      241 lqfppegwlr lslnngsith lvirpngrva lrtlgdtgfm ppdkitrs
//
LOCUS       NP_001278101             653 aa            linear   ROD 09-OCT-2023
DEFINITION  nuclear factor of activated T-cells, cytoplasmic 2 isoform i [Mus
            musculus].
ACCESSION   NP_001278101 XP_006498958
VERSION     NP_001278101.1
DBSOURCE    REFSEQ: accession NM_001291172.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 653)
  AUTHORS   Fu Y, Wang J, Liu C, Liao K, Gao X, Tang R, Fan B, Hong Y, Xiao N,
            Xiao C and Liu WH.
  TITLE     Glycogen synthase kinase 3 controls T-cell exhaustion by regulating
            NFAT activation
  JOURNAL   Cell Mol Immunol 20 (10), 1127-1139 (2023)
   PUBMED   37553428
  REMARK    GeneRIF: Glycogen synthase kinase 3 controls T-cell exhaustion by
            regulating NFAT activation.
REFERENCE   2  (residues 1 to 653)
  AUTHORS   Wan X, Zhao S, Dai Y, Zhang J, Shen Y, Gong L and Le Q.
  TITLE     WNT16b promotes the proliferation and self-renewal of human limbal
            epithelial stem/progenitor cells via activating the
            calcium/calcineurin A/NFATC2 pathway
  JOURNAL   Cell Prolif 56 (10), e13460 (2023)
   PUBMED   36974338
  REMARK    GeneRIF: WNT16b promotes the proliferation and self-renewal of
            human limbal epithelial stem/progenitor cells via activating the
            calcium/calcineurin A/NFATC2 pathway.
REFERENCE   3  (residues 1 to 653)
  AUTHORS   Jiang F, Guo Y, Hu L, Zhang M, Meng J, Si Y and Shi H.
  TITLE     Role of nuclear factor of activated T Cells-1 in Sepsis-induced
            behavioral deficits in mice
  JOURNAL   Brain Res 1806, 148299 (2023)
   PUBMED   36842570
REFERENCE   4  (residues 1 to 653)
  AUTHORS   Nagai J, Lin J and Boyce JA.
  TITLE     Macrophage P2Y6 Receptor Signaling Selectively Activates NFATC2 and
            Suppresses Allergic Lung Inflammation
  JOURNAL   J Immunol 209 (12), 2293-2303 (2022)
   PUBMED   36307120
  REMARK    GeneRIF: Macrophage P2Y6 Receptor Signaling Selectively Activates
            NFATC2 and Suppresses Allergic Lung Inflammation.
REFERENCE   5  (residues 1 to 653)
  AUTHORS   Zhu L, Zhou X, Gu M, Kim J, Li Y, Ko CJ, Xie X, Gao T, Cheng X and
            Sun SC.
  TITLE     Dapl1 controls NFATc2 activation to regulate CD8+ T cell exhaustion
            and responses in chronic infection and cancer
  JOURNAL   Nat Cell Biol 24 (7), 1165-1176 (2022)
   PUBMED   35773432
REFERENCE   6  (residues 1 to 653)
  AUTHORS   Vihma H, Pruunsild P and Timmusk T.
  TITLE     Alternative splicing and expression of human and mouse NFAT genes
  JOURNAL   Genomics 92 (5), 279-291 (2008)
   PUBMED   18675896
REFERENCE   7  (residues 1 to 653)
  AUTHORS   Ho SN, Thomas DJ, Timmerman LA, Li X, Francke U and Crabtree GR.
  TITLE     NFATc3, a lymphoid-specific NFATc family member that is
            calcium-regulated and exhibits distinct DNA binding specificity
  JOURNAL   J Biol Chem 270 (34), 19898-19907 (1995)
   PUBMED   7650004
REFERENCE   8  (residues 1 to 653)
  AUTHORS   Jain J, Burgeon E, Badalian TM, Hogan PG and Rao A.
  TITLE     A similar DNA-binding motif in NFAT family proteins and the Rel
            homology region
  JOURNAL   J Biol Chem 270 (8), 4138-4145 (1995)
   PUBMED   7876165
REFERENCE   9  (residues 1 to 653)
  AUTHORS   Li X, Ho SN, Luna J, Giacalone J, Thomas DJ, Timmerman LA, Crabtree
            GR and Francke U.
  TITLE     Cloning and chromosomal localization of the human and murine genes
            for the T-cell transcription factors NFATc and NFATp
  JOURNAL   Cytogenet Cell Genet 68 (3-4), 185-191 (1995)
   PUBMED   7842733
REFERENCE   10 (residues 1 to 653)
  AUTHORS   Ho AM, Jain J, Rao A and Hogan PG.
  TITLE     Expression of the transcription factor NFATp in a neuronal cell
            line and in the murine nervous system
  JOURNAL   J Biol Chem 269 (45), 28181-28186 (1994)
   PUBMED   7961754
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK044489.1, EU887599.1 and AW049827.1.
            
            On Mar 27, 2014 this sequence version replaced XP_006498958.1.
            
            Transcript Variant: This variant (9, also known as IA-IIL-VIIa)
            contains alternate 5' and 3' exon structure, and it thus differs in
            both UTRs and in the 5' and 3' coding regions, compared to variant
            1. The encoded isoform (i) has distinct N- and C-termini and is
            shorter than isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK044489.1, EU887599.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..653
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 88.91 cM"
     Protein         1..653
                     /product="nuclear factor of activated T-cells, cytoplasmic
                     2 isoform i"
                     /note="nuclear factor of activated T-cells, cytoplasmic 2;
                     NFAT pre-existing subunit; T-cell transcription factor
                     NFAT1"
                     /calculated_mol_wt=69806
     Region          380..554
                     /region_name="RHD-n_NFAT"
                     /note="N-terminal sub-domain of the Rel homology domain
                     (RHD) of nuclear factor of activated T-cells (NFAT)
                     proteins; cd07881"
                     /db_xref="CDD:143641"
     Site            order(403,406,408..409,411..413,461,502,504..505,519..520,
                     522,553)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143641"
     Region          559..>598
                     /region_name="IPT"
                     /note="Immunoglobulin-like fold, Plexins, Transcription
                     factors (IPT). IPTs are also known as Transcription factor
                     ImmunoGlobin (TIG) domains. They are present in
                     intracellular transcription factors, cell surface
                     receptors (such as plexins and scatter factor...; cl15674"
                     /db_xref="CDD:449574"
     CDS             1..653
                     /gene="Nfatc2"
                     /gene_synonym="NF-ATc2; NF-ATp; NFAT1; NFAT1-D; Nfatp"
                     /coded_by="NM_001291172.1:120..2081"
                     /note="isoform i is encoded by transcript variant 9"
                     /db_xref="CCDS:CCDS71201.1"
                     /db_xref="GeneID:18019"
                     /db_xref="MGI:MGI:102463"
ORIGIN      
        1 mqrpalrrpg prqplrtmgs adreepiahk aisspsglay pddvldyglk pcnplaslsg
       61 eppgrfgepd sigfqnflsp vkpagasgps prieitpshe lmqaggalrg rdaglspeqp
      121 alalagvaas prftlpvpgy egyreplcls passgssasf isdtfspyts pcvspnnagp
      181 ddlcpqfqni pahysprtsp imsprtslae dsclgrhspv prpasrsssp gakrrhscae
      241 alvaplpaas pqrsrspspq psphvalqdd sipagyppta gsavlmdaln tlatdspcgi
      301 pskiwktspd ptpvstapsk aglarhiypt veflgpceqe errnsapesi llvpptwpkq
      361 lvpaipicsi pvtaslpple wplsnqsgsy elrievqpkp hhrahyeteg srgavkaptg
      421 ghpvvqlhgy menkplglqi figtaderil kphafyqvhr itgktvttts yekivgntkv
      481 leiplepknn mratidcagi lklrnadiel rkgetdigrk ntrvrlvfrv hvpepsgriv
      541 slqaasnpie csqrsahelp mverqdmdsc lvyggqqmil tgqnftaesk vvfmekttgp
      601 agtcetrplp islisadrls pwlsrlqrnp pgsvfrcsvl lpapgsslvl lal
//
LOCUS       NP_001344565             796 aa            linear   ROD 09-OCT-2023
DEFINITION  DNA-binding protein SATB1 isoform 2 [Mus musculus].
ACCESSION   NP_001344565 XP_006523986
VERSION     NP_001344565.1
DBSOURCE    REFSEQ: accession NM_001357636.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 796)
  AUTHORS   Naito T, Ise M, Tanaka Y, Kohwi-Shigematsu T and Kondo M.
  TITLE     Crucial Roles of SATB1 in Regulation of Thymocyte Migration after
            Positive Selection
  JOURNAL   J Immunol 211 (2), 209-218 (2023)
   PUBMED   37256264
  REMARK    GeneRIF: Crucial Roles of SATB1 in Regulation of Thymocyte
            Migration after Positive Selection.
REFERENCE   2  (residues 1 to 796)
  AUTHORS   Nomura A, Kobayashi T, Seo W, Ohno-Oishi M, Kakugawa K, Muroi S,
            Yoshida H, Endo TA, Moro K and Taniuchi I.
  TITLE     Identification of a novel enhancer essential for Satb1 expression
            in TH2 cells and activated ILC2s
  JOURNAL   Life Sci Alliance 6 (8), e202301897 (2023)
   PUBMED   37193606
  REMARK    GeneRIF: Identification of a novel enhancer essential for Satb1
            expression in TH2 cells and activated ILC2s.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 796)
  AUTHORS   Knowles SJ, Stafford AM, Zaman T, Angara K, Williams MR, Newbern JM
            and Vogt D.
  TITLE     Distinct hyperactive RAS/MAPK alleles converge on common GABAergic
            interneuron core programs
  JOURNAL   Development 150 (10) (2023)
   PUBMED   37254876
REFERENCE   4  (residues 1 to 796)
  AUTHORS   Wang B, Ji L and Bian Q.
  TITLE     SATB1 regulates 3D genome architecture in T cells by constraining
            chromatin interactions surrounding CTCF-binding sites
  JOURNAL   Cell Rep 42 (4), 112323 (2023)
   PUBMED   37000624
  REMARK    GeneRIF: SATB1 regulates 3D genome architecture in T cells by
            constraining chromatin interactions surrounding CTCF-binding sites.
REFERENCE   5  (residues 1 to 796)
  AUTHORS   Vasilopoulos N, Kaplanian A, Vinos M, Katsaiti Y, Christodoulou O,
            Denaxa M and Skaliora I.
  TITLE     The role of selective SATB1 deletion in somatostatin expressing
            interneurons on endogenous network activity and the transition to
            epilepsy
  JOURNAL   J Neurosci Res 101 (4), 424-447 (2023)
   PUBMED   36541427
  REMARK    GeneRIF: The role of selective SATB1 deletion in somatostatin
            expressing interneurons on endogenous network activity and the
            transition to epilepsy.
REFERENCE   6  (residues 1 to 796)
  AUTHORS   Seo J, Lozano MM and Dudley JP.
  TITLE     Nuclear matrix binding regulates SATB1-mediated transcriptional
            repression
  JOURNAL   J Biol Chem 280 (26), 24600-24609 (2005)
   PUBMED   15851481
  REMARK    GeneRIF: SATB1-mediated transcriptional repression is regulated by
            nuclear matrix binding
REFERENCE   7  (residues 1 to 796)
  AUTHORS   Nie H, Maika SD, Tucker PW and Gottlieb PD.
  TITLE     A role for SATB1, a nuclear matrix association region-binding
            protein, in the development of CD8SP thymocytes and peripheral T
            lymphocytes
  JOURNAL   J Immunol 174 (8), 4745-4752 (2005)
   PUBMED   15814699
  REMARK    GeneRIF: essential role for SATB1 late in the development and
            maturation of CD8SP T cells
REFERENCE   8  (residues 1 to 796)
  AUTHORS   Cai S, Han HJ and Kohwi-Shigematsu T.
  TITLE     Tissue-specific nuclear architecture and gene expression regulated
            by SATB1
  JOURNAL   Nat Genet 34 (1), 42-51 (2003)
   PUBMED   12692553
  REMARK    GeneRIF: in thymocyte nuclei, SATB1 has a cage-like 'network'
            distribution circumscribing heterochromatin and selectively tethers
            specialized DNA sequences onto its network
REFERENCE   9  (residues 1 to 796)
  AUTHORS   Alvarez JD, Yasui DH, Niida H, Joh T, Loh DY and Kohwi-Shigematsu
            T.
  TITLE     The MAR-binding protein SATB1 orchestrates temporal and spatial
            expression of multiple genes during T-cell development
  JOURNAL   Genes Dev 14 (5), 521-535 (2000)
   PUBMED   10716941
REFERENCE   10 (residues 1 to 796)
  AUTHORS   Nakagomi K, Kohwi Y, Dickinson LA and Kohwi-Shigematsu T.
  TITLE     A novel DNA-binding motif in the nuclear matrix attachment
            DNA-binding protein SATB1
  JOURNAL   Mol Cell Biol 14 (3), 1852-1860 (1994)
   PUBMED   8114718
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154796.2, AC131975.28 and AW045567.1.
            
            On Nov 4, 2017 this sequence version replaced XP_006523986.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.251618.1,
                                           SRR1660819.36183.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..796
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 26.81 cM"
     Protein         1..796
                     /product="DNA-binding protein SATB1 isoform 2"
                     /note="DNA-binding protein Satb1"
                     /calculated_mol_wt=89031
     Region          72..170
                     /region_name="ULD"
                     /note="Ubiquitin-like oligomerization domain of SATB;
                     pfam16534"
                     /db_xref="CDD:435405"
     Site            order(75,77,94..98,100,132,134,137..138,144..147,155..156,
                     159..161,163..164)
                     /site_type="other"
                     /note="tetramer interface [polypeptide binding]"
                     /db_xref="CDD:211426"
     Region          176..247
                     /region_name="CUTL"
                     /note="CUT1-like DNA-binding domain of SATB; pfam16557"
                     /db_xref="CDD:435427"
     Region          372..444
                     /region_name="CUT"
                     /note="CUT domain; pfam02376"
                     /db_xref="CDD:426745"
     Region          497..567
                     /region_name="CUT"
                     /note="CUT domain; pfam02376"
                     /db_xref="CDD:426745"
     Region          677..734
                     /region_name="HOX"
                     /note="Homeodomain; smart00389"
                     /db_xref="CDD:197696"
     Site            order(679..682,684,702,708,721,723..724,727..728,730..732,
                     734..735)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     Site            order(680,683,724,727..728,731)
                     /site_type="other"
                     /note="specific DNA base contacts [nucleotide binding]"
                     /db_xref="CDD:238039"
     CDS             1..796
                     /gene="Satb1"
                     /gene_synonym="2610306G12Rik"
                     /coded_by="NM_001357636.1:452..2842"
                     /note="isoform 2 is encoded by transcript variant 6"
                     /db_xref="GeneID:20230"
                     /db_xref="MGI:MGI:105084"
ORIGIN      
        1 mdhlneatqg kehsemsnnv sdpkgppaki arleqngspl grgrlgstgg kmqgvplkhs
       61 ghlmktnlrk gtmlpvfcvv ehyenaieyd ckeehaefvl vrkdmlfnql iemallslgy
      121 shssaaqakg liqvgkwnpv plsyvtdapd atvadmlqdv yhvvtlkiql hscpkledlp
      181 peqwshttvr nalkdllkdm nqsslakecp lsqsmissiv nstyyanvsa akcqefgrwy
      241 khfkktkdmm vemdslsels qqganhvnfg qqpvpgntae qppspaqlsh gsqpsvrtpl
      301 pnlhpglvst pispqlvnqq lvmaqllnqq yavnrllaqq slnqqylnhp ppvsrsmnkp
      361 leqqvstnte vsseiyqwvr delkragisq avfarvafnr tqgllseilr keedpktasq
      421 sllvnlramq nflqlpeaer driyqderer slnaasamgp apllstppsr ppqvktatla
      481 terngkpenn tmninasiyd eiqqemkrak vsqalfakva atksqgwlce llrwkedpsp
      541 enrtlwenls mirrflslpq perdaiyeqe snavhhhgdr pphiihvpae qiqslspstl
      601 gkgesrgvfl pslltpapwp haapqqqqqq qqqqqqqqqp pppppqpqpq pqagprlppr
      661 qptvassaes deenrqktrp rtkisvealg ilqsfiqdvg lypdeeaiqt lsaqldlpky
      721 tiikffqnqr yylkhhgklk dnsglevdva eykdeellkd leesvqdkna ntlfsvklee
      781 elsvegstdv nadlkd
//
LOCUS       NP_001386155              45 aa            linear   ROD 09-OCT-2023
DEFINITION  nuclear factor erythroid 2-related factor 2 isoform 2 [Mus
            musculus].
ACCESSION   NP_001386155
VERSION     NP_001386155.1
DBSOURCE    REFSEQ: accession NM_001399226.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 45)
  AUTHORS   Li F, Huang H, Zhao P, Jiang J, Ding X, Lu D and Ji L.
  TITLE     Curculigoside mitigates dextran sulfate sodium-induced colitis by
            activation of KEAP1-NRF2 interaction to inhibit oxidative damage
            and autophagy of intestinal epithelium barrier
  JOURNAL   Int J Mol Med 52 (5) (2023)
   PUBMED   37772380
  REMARK    GeneRIF: Curculigoside mitigates dextran sulfate sodium-induced
            colitis by activation of KEAP1-NRF2 interaction to inhibit
            oxidative damage and autophagy of intestinal epithelium barrier.
REFERENCE   2  (residues 1 to 45)
  AUTHORS   Dong C, Li J, Tang Q, Wang Y, Zeng C, Du L and Sun Q.
  TITLE     Denervation aggravates renal ischemia reperfusion injury via
            BMAL1-mediated Nrf2/ARE pathway
  JOURNAL   Arch Biochem Biophys 746, 109736 (2023)
   PUBMED   37657745
  REMARK    GeneRIF: Denervation aggravates renal ischemia reperfusion injury
            via BMAL1-mediated Nrf2/ARE pathway.
REFERENCE   3  (residues 1 to 45)
  AUTHORS   Vaikunthanathan T, Landmann E, Correa DM, Romano M, Trevelin SC,
            Peng Q, Crespo E, Corrado M, Lozano JJ, Pearce EL, Perpinan E,
            Zoccarato A, Siew L, Edwards-Hicks J, Khan R, Luu NT, Thursz MR,
            Newsome PN, Martinez-Llordella M, Shah N, Lechler RI, Shah AM,
            Sanchez-Fueyo A, Lombardi G and Safinia N.
  TITLE     Dysregulated anti-oxidant signalling and compromised mitochondrial
            integrity negatively influence regulatory T cell function and
            viability in liver disease
  JOURNAL   EBioMedicine 95, 104778 (2023)
   PUBMED   37657135
REFERENCE   4  (residues 1 to 45)
  AUTHORS   You T, Zhao Y, Liu S and Xu H.
  TITLE     Lactiplantibacillus plantarum P101 Attenuated
            Cyclophosphamide-Induced Liver Injury in Mice by Regulating the
            Nrf2/ARE Signaling Pathway
  JOURNAL   Int J Mol Sci 24 (17), 13424 (2023)
   PUBMED   37686229
  REMARK    GeneRIF: Lactiplantibacillus plantarum P101 Attenuated
            Cyclophosphamide-Induced Liver Injury in Mice by Regulating the
            Nrf2/ARE Signaling Pathway.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 45)
  AUTHORS   Wakabayashi N, Yagishita Y, Joshi T and Kensler TW.
  TITLE     Forced Hepatic Expression of NRF2 or NQO1 Impedes Hepatocyte Lipid
            Accumulation in a Lipodystrophy Mouse Model
  JOURNAL   Int J Mol Sci 24 (17), 13345 (2023)
   PUBMED   37686150
  REMARK    GeneRIF: Forced Hepatic Expression of NRF2 or NQO1 Impedes
            Hepatocyte Lipid Accumulation in a Lipodystrophy Mouse Model.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 45)
  AUTHORS   Yehiely F, Bamborough P, Da Costa M, Perry BJ, Thinakaran G, Cohen
            FE, Carlson GA and Prusiner SB.
  TITLE     Identification of candidate proteins binding to prion protein
  JOURNAL   Neurobiol Dis 3 (4), 339-355 (1997)
   PUBMED   9173930
  REMARK    Erratum:[Neurobiol Dis 2002 Jun;10(1):67-8]
REFERENCE   7  (residues 1 to 45)
  AUTHORS   Chan K, Lu R, Chang JC and Kan YW.
  TITLE     NRF2, a member of the NFE2 family of transcription factors, is not
            essential for murine erythropoiesis, growth, and development
  JOURNAL   Proc Natl Acad Sci U S A 93 (24), 13943-13948 (1996)
   PUBMED   8943040
REFERENCE   8  (residues 1 to 45)
  AUTHORS   Oyake T, Itoh K, Motohashi H, Hayashi N, Hoshino H, Nishizawa M,
            Yamamoto M and Igarashi K.
  TITLE     Bach proteins belong to a novel family of BTB-basic leucine zipper
            transcription factors that interact with MafK and regulate
            transcription through the NF-E2 site
  JOURNAL   Mol Cell Biol 16 (11), 6083-6095 (1996)
   PUBMED   8887638
REFERENCE   9  (residues 1 to 45)
  AUTHORS   Shivdasani RA and Orkin SH.
  TITLE     Erythropoiesis and globin gene expression in mice lacking the
            transcription factor NF-E2
  JOURNAL   Proc Natl Acad Sci U S A 92 (19), 8690-8694 (1995)
   PUBMED   7567998
REFERENCE   10 (residues 1 to 45)
  AUTHORS   Chui DH, Tang W and Orkin SH.
  TITLE     cDNA cloning of murine Nrf 2 gene, coding for a p45 NF-E2 related
            transcription factor
  JOURNAL   Biochem Biophys Res Commun 209 (1), 40-46 (1995)
   PUBMED   7726861
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL772404.5.
            
            Summary: This gene encodes a transcription factor which is a member
            of a small family of basic leucine zipper (bZIP) proteins. The
            encoded transcription factor regulates genes which contain
            antioxidant response elements (ARE) in their promoters; many of
            these genes encode proteins involved in response to injury and
            inflammation which includes the production of free radicals.
            [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (2) lacks several alternate 3'
            exons and uses an alternate 3' terminal exon, compared to variant
            1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057948.1, AK029360.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..45
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 44.75 cM"
     Protein         1..45
                     /product="nuclear factor erythroid 2-related factor 2
                     isoform 2"
                     /note="nuclear factor erythroid 2-related factor 2;
                     NFE2-related factor 2; NF-E2-related factor 2"
                     /calculated_mol_wt=4931
     CDS             1..45
                     /gene="Nfe2l2"
                     /gene_synonym="Nrf2"
                     /coded_by="NM_001399226.1:256..393"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="GeneID:18024"
                     /db_xref="MGI:MGI:108420"
ORIGIN      
        1 mmdlelpppg lqsqqsdgcp lggllcvqtr rykfwkevse haesv
//
LOCUS       NP_001193314             503 aa            linear   ROD 09-OCT-2023
DEFINITION  mitochondrial antiviral-signaling protein isoform 1 [Mus musculus].
ACCESSION   NP_001193314
VERSION     NP_001193314.1
DBSOURCE    REFSEQ: accession NM_001206385.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 503)
  AUTHORS   Liu F, Zhuang W, Song B, Yang Y, Liu J, Zheng Y, Liu B, Zheng J,
            Zhao W and Gao C.
  TITLE     MAVS-loaded unanchored Lys63-linked polyubiquitin chains activate
            the RIG-I-MAVS signaling cascade
  JOURNAL   Cell Mol Immunol 20 (10), 1186-1202 (2023)
   PUBMED   37582970
  REMARK    GeneRIF: MAVS-loaded unanchored Lys63-linked polyubiquitin chains
            activate the RIG-I-MAVS signaling cascade.
REFERENCE   2  (residues 1 to 503)
  AUTHORS   Ingle H, Makimaa H, Aggarwal S, Deng H, Foster L, Li Y, Kennedy EA,
            Peterson ST, Wilen CB, Lee S, Suthar MS and Baldridge MT.
  TITLE     IFN-lambda derived from nonsusceptible enterocytes acts on tuft
            cells to limit persistent norovirus
  JOURNAL   Sci Adv 9 (37), eadi2562 (2023)
   PUBMED   37703370
REFERENCE   3  (residues 1 to 503)
  AUTHORS   He QQ, Huang Y, Nie L, Ren S, Xu G, Deng F, Cheng Z, Zuo Q, Zhang
            L, Cai H, Wang Q, Wang F, Ren H, Yan H, Xu K, Zhou L, Lu M, Lu Z,
            Zhu Y and Liu S.
  TITLE     MAVS integrates glucose metabolism and RIG-I-like receptor
            signaling
  JOURNAL   Nat Commun 14 (1), 5343 (2023)
   PUBMED   37660168
  REMARK    GeneRIF: MAVS integrates glucose metabolism and RIG-I-like receptor
            signaling.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 503)
  AUTHORS   Li J, Zhang R, Wang C, Zhu J, Ren M, Jiang Y, Hou X, Du Y, Wu Q, Qi
            S, Li L, Chen S, Yang H and Hou F.
  TITLE     WDR77 inhibits prion-like aggregation of MAVS to limit antiviral
            innate immune response
  JOURNAL   Nat Commun 14 (1), 4824 (2023)
   PUBMED   37563140
  REMARK    GeneRIF: WDR77 inhibits prion-like aggregation of MAVS to limit
            antiviral innate immune response.
            Erratum:[Nat Commun. 2023 Sep 25;14(1):5960. PMID: 37749076]
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 503)
  AUTHORS   Wang H, Sun W, Traba J, Wu J, Qi CF, Amo L, Kole HK, Scott B, Singh
            K, Sack MN and Bolland S.
  TITLE     MAVS Positively Regulates Mitochondrial Integrity and Metabolic
            Fitness in B Cells
  JOURNAL   Immunohorizons 7 (8), 587-599 (2023)
   PUBMED   37610299
  REMARK    GeneRIF: MAVS Positively Regulates Mitochondrial Integrity and
            Metabolic Fitness in B Cells.
REFERENCE   6  (residues 1 to 503)
  AUTHORS   Kumar H, Kawai T, Kato H, Sato S, Takahashi K, Coban C, Yamamoto M,
            Uematsu S, Ishii KJ, Takeuchi O and Akira S.
  TITLE     Essential role of IPS-1 in innate immune responses against RNA
            viruses
  JOURNAL   J Exp Med 203 (7), 1795-1803 (2006)
   PUBMED   16785313
  REMARK    GeneRIF: IPS-1 is the sole adapter in both retinoic acid-inducible
            gene (RIG-I) and melanoma differentiation-associated gene 5 (Mda5)
            signaling that mediates effective responses against a variety of
            RNA viruses.
REFERENCE   7  (residues 1 to 503)
  AUTHORS   Sun Q, Sun L, Liu HH, Chen X, Seth RB, Forman J and Chen ZJ.
  TITLE     The specific and essential role of MAVS in antiviral innate immune
            responses
  JOURNAL   Immunity 24 (5), 633-642 (2006)
   PUBMED   16713980
REFERENCE   8  (residues 1 to 503)
  AUTHORS   Meylan E, Curran J, Hofmann K, Moradpour D, Binder M,
            Bartenschlager R and Tschopp J.
  TITLE     Cardif is an adaptor protein in the RIG-I antiviral pathway and is
            targeted by hepatitis C virus
  JOURNAL   Nature 437 (7062), 1167-1172 (2005)
   PUBMED   16177806
REFERENCE   9  (residues 1 to 503)
  AUTHORS   Xu LG, Wang YY, Han KJ, Li LY, Zhai Z and Shu HB.
  TITLE     VISA is an adapter protein required for virus-triggered IFN-beta
            signaling
  JOURNAL   Mol Cell 19 (6), 727-740 (2005)
   PUBMED   16153868
  REMARK    GeneRIF: Data suggest that VISA is critically involved in both
            virus-triggered TLR3-independent and TLR3-mediated antiviral
            interferon signaling.
REFERENCE   10 (residues 1 to 503)
  AUTHORS   Seth RB, Sun L, Ea CK and Chen ZJ.
  TITLE     Identification and characterization of MAVS, a mitochondrial
            antiviral signaling protein that activates NF-kappaB and IRF 3
  JOURNAL   Cell 122 (5), 669-682 (2005)
   PUBMED   16125763
  REMARK    GeneRIF: The overexpression of mitochondrial antiviral
            signaling(MAVS)induces the expression of IFN-beta through
            activation of NF-kappaB and IRF 3, thus boosting antiviral
            immunity.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK153748.1, AK028421.1 and AL808128.4.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1 and 2 encode the same isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC020006.1, AK028421.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: PMID: 16125763; reported by
                                                  MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 63.3 cM"
     Protein         1..503
                     /product="mitochondrial antiviral-signaling protein
                     isoform 1"
                     /note="IFN-beta promoter stimulator-1; mitochondrial
                     anti-viral signaling protein; virus-induced signaling
                     adapter; CARD adapter inducing interferon beta; interferon
                     beta promoter stimulator protein 1"
                     /calculated_mol_wt=53268
     Region          3..93
                     /region_name="CARD_IPS1"
                     /note="Caspase activation and recruitment domain (CARD)
                     found in IPS-1; cd08811"
                     /db_xref="CDD:260073"
     Region          10..77
                     /region_name="Required for interaction with NLRX1.
                     /evidence=ECO:0000250|UniProtKB:Q7Z434"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCF0.1)"
     Region          119..202
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCF0.1)"
     Region          143..147
                     /region_name="Interaction with TRAF2.
                     /evidence=ECO:0000250|UniProtKB:Q7Z434"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCF0.1)"
     Site            152
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8VCF0.1)"
     Region          153..158
                     /region_name="Interaction with TRAF6 1.
                     /evidence=ECO:0000250|UniProtKB:Q7Z434"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCF0.1)"
     Site            157
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q7Z434; propagated from
                     UniProtKB/Swiss-Prot (Q8VCF0.1)"
     Site            172
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8VCF0.1)"
     Site            186
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q7Z434; propagated from
                     UniProtKB/Swiss-Prot (Q8VCF0.1)"
     Site            220
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q7Z434; propagated from
                     UniProtKB/Swiss-Prot (Q8VCF0.1)"
     Site            234
                     /site_type="methylation"
                     /note="Asymmetric dimethylarginine.
                     /evidence=ECO:0007744|PubMed:24129315; propagated from
                     UniProtKB/Swiss-Prot (Q8VCF0.1)"
     Site            251
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q7Z434; propagated from
                     UniProtKB/Swiss-Prot (Q8VCF0.1)"
     Site            256
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q7Z434; propagated from
                     UniProtKB/Swiss-Prot (Q8VCF0.1)"
     Region          337..503
                     /region_name="Interaction with DHX33.
                     /evidence=ECO:0000269|PubMed:24037184"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCF0.1)"
     Region          346..398
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCF0.1)"
     Site            384
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8VCF0.1)"
     Site            405..406
                     /site_type="cleavage"
                     /note="Cleavage, by CASP3.
                     /evidence=ECO:0000250|UniProtKB:Q7Z434; propagated from
                     UniProtKB/Swiss-Prot (Q8VCF0.1)"
     Region          415..418
                     /region_name="pLxIS motif.
                     /evidence=ECO:0000250|UniProtKB:Q7Z434"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCF0.1)"
     Site            418
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by TBK1.
                     /evidence=ECO:0000250|UniProtKB:Q7Z434; propagated from
                     UniProtKB/Swiss-Prot (Q8VCF0.1)"
     Region          431..436
                     /region_name="Interaction with TRAF6 2.
                     /evidence=ECO:0000250|UniProtKB:Q7Z434"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCF0.1)"
     Region          446..466
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCF0.1)"
     Site            479..496
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCF0.1)"
     CDS             1..503
                     /gene="Mavs"
                     /gene_synonym="cardif; D430028G21Rik; IPS-1; Visa"
                     /coded_by="NM_001206385.1:124..1635"
                     /note="isoform 1 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS16760.1"
                     /db_xref="GeneID:228607"
                     /db_xref="MGI:MGI:2444773"
ORIGIN      
        1 mtfaedktyk yirdnhskfc cvdvleilpy lscltasdqd rlrasyrqig nrdtlwglfn
       61 nlqrrpgwve vfiralqice lpgladqvtr vyqsylppgt slrsleplql pdfpaavsgp
      121 safapghnip dhglretpsc pkpvqdtqpp espvenseql lqtnsgavar msggslipsp
      181 nqqalspqps rehqeqepel ggahaanvas vpiatygpvs ptvsfqplpr talrtnllsg
      241 vtvsalsadt slsssstgsa fakgagdqak aatcfsttlt nsvttssvps prlvpvktms
      301 sklplsskst aamtstvltn tapsklpsns vyagtvpsrv pasvakapan tippernskq
      361 aketpegpat kvttggnqtg pnssirslhs gpemskpgvl vsqldepfsa csvdlaisps
      421 sslvsepnhg peeneyssfr iqvdespsad llgspeplat qqpqeeeehc assmpwakwl
      481 gatsallavf lavmlyrsrr laq
//
LOCUS       NP_001349217             525 aa            linear   ROD 09-OCT-2023
DEFINITION  CUGBP Elav-like family member 4 isoform 13 [Mus musculus].
ACCESSION   NP_001349217 XP_017173280
VERSION     NP_001349217.1
DBSOURCE    REFSEQ: accession NM_001362288.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 525)
  AUTHORS   Salamon I, Park Y, Miskic T, Kopic J, Matteson P, Page NF, Roque A,
            McAuliffe GW, Favate J, Garcia-Forn M, Shah P, Judas M, Millonig
            JH, Kostovic I, De Rubeis S, Hart RP, Krsnik Z and Rasin MR.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    GeneRIF: Celf4 controls mRNA translation underlying synaptic
            development in the prenatal mammalian neocortex.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 525)
  AUTHORS   Shen Y, Zhang C, Xiao K, Liu D and Xie G.
  TITLE     CELF4 regulates spine formation and depression-like behaviors of
            mice
  JOURNAL   Biochem Biophys Res Commun 605, 39-44 (2022)
   PUBMED   35306363
  REMARK    GeneRIF: CELF4 regulates spine formation and depression-like
            behaviors of mice.
REFERENCE   3  (residues 1 to 525)
  AUTHORS   Moreau MX, Saillour Y, Cwetsch AW, Pierani A and Causeret F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   4  (residues 1 to 525)
  AUTHORS   Li C, Li X, Bi Z, Sugino K, Wang G, Zhu T and Liu Z.
  TITLE     Comprehensive transcriptome analysis of cochlear spiral ganglion
            neurons at multiple ages
  JOURNAL   Elife 9, e50491 (2020)
   PUBMED   31913118
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 525)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 525)
  AUTHORS   Ladd AN, Taffet G, Hartley C, Kearney DL and Cooper TA.
  TITLE     Cardiac tissue-specific repression of CELF activity disrupts
            alternative splicing and causes cardiomyopathy
  JOURNAL   Mol Cell Biol 25 (14), 6267-6278 (2005)
   PUBMED   15988035
  REMARK    GeneRIF: CELF protein activity is required for normal alternative
            splicing in the heart in vivo and normal CELF-mediated alternative
            splicing regulation is in turn required for normal cardiac
            function.
REFERENCE   7  (residues 1 to 525)
  AUTHORS   Meins M, Schlickum S, Wilhelm C, Missbach J, Yadav S, Glaser B,
            Grzmil M, Burfeind P and Laccone F.
  TITLE     Identification and characterization of murine Brunol4, a new member
            of the elav/bruno family
  JOURNAL   Cytogenet Genome Res 97 (3-4), 254-260 (2002)
   PUBMED   12438720
  REMARK    GeneRIF: cloning and characterization
REFERENCE   8  (residues 1 to 525)
  AUTHORS   Ladd AN, Charlet N and Cooper TA.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   9  (residues 1 to 525)
  AUTHORS   Good PJ, Chen Q, Warner SJ and Herring DC.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
REFERENCE   10 (residues 1 to 525)
  AUTHORS   Yulug IG, Egan SE, See CG and Fisher EM.
  TITLE     Mapping GRB2, a signal transduction gene in the human and the mouse
  JOURNAL   Genomics 22 (2), 313-318 (1994)
   PUBMED   7806216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121094.8 and AC144938.3.
            
            On Apr 12, 2018 this sequence version replaced XP_017173280.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR6116558.147019.1,
                                           SRR1660815.4726.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..525
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 13.92 cM"
     Protein         1..525
                     /product="CUGBP Elav-like family member 4 isoform 13"
                     /note="CUG-BP- and ETR-3-like factor 4; bruno-like protein
                     4; RNA-binding protein BRUNOL-4; bruno-like 4, RNA binding
                     protein"
                     /calculated_mol_wt=55865
     Region          49..135
                     /region_name="RRM1_CELF3_4_5_6"
                     /note="RNA recognition motif 1 (RRM1) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12632"
                     /db_xref="CDD:410041"
     Site            order(55,57,59..60,63,82,84,86,95..97,99,129,131)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410041"
     Region          140..220
                     /region_name="RRM2_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12635"
                     /db_xref="CDD:410043"
     Site            order(142,144,146..147,150,169,171,173,181..183,185,215,
                     217)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410043"
     Region          406..>434
                     /region_name="RRM_SF"
                     /note="RNA recognition motif (RRM) superfamily; cl17169"
                     /db_xref="CDD:450164"
     CDS             1..525
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /coded_by="NM_001362288.1:531..2108"
                     /note="isoform 13 is encoded by transcript variant 19"
                     /db_xref="GeneID:108013"
                     /db_xref="MGI:MGI:1932407"
ORIGIN      
        1 myikmatlan gqadnaslst nglgsspgsa ghmnglshsp gnpstipmkd hdaiklfigq
       61 iprnldekdl kplfeefgki yeltvlkdrf tgmhkgcafl tyceresalk aqsalheqkt
      121 lpgmnrpiqv kpadsesrgd rklfvgmlnk qqseddvrrl feafgnieec tilrgpdgns
      181 kgcafvkyss haeaqaaina lhgsqtmpga ssslvvkfad tdkertmrrm qqmagqmgmf
      241 npmaipfgay gayaqalmqq qaalmasvaq ggylnpmaaf aaaqmqqmaa lnmnglaaap
      301 mtptsggstp pgitapavps ipspigvngf tglppqangq paaeavfang ihpypaqspt
      361 aadplqqaya gvqqyagpaa ypaaygqisq afpqpppmip qqqregpegc nlliyhlpqe
      421 fgdaelmqmf lpfgrhpvps rcqapscqgg qcaisssarr lrelrqpgqr tdrhpgherl
      481 pdrheeaqga aeaaqrrqsp vlsaggsvpr grpglaqgrm lnglh
//
LOCUS       NP_998824                770 aa            linear   ROD 09-OCT-2023
DEFINITION  signal transducer and activator of transcription 3 isoform 1 [Mus
            musculus].
ACCESSION   NP_998824
VERSION     NP_998824.1
DBSOURCE    REFSEQ: accession NM_213659.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 770)
  AUTHORS   Xiao D, Zeng T, Zhu W, Yu ZZ, Huang W, Yi H, Lu SS, Feng J, Feng
            XP, Wu D, Wen Q, Zhou JH, Yuan L, Zhuang W and Xiao ZQ.
  TITLE     ANXA1 Promotes Tumor Immune Evasion by Binding PARP1 and
            Upregulating Stat3-Induced Expression of PD-L1 in Multiple Cancers
  JOURNAL   Cancer Immunol Res 11 (10), 1367-1383 (2023)
   PUBMED   37566399
  REMARK    GeneRIF: ANXA1 Promotes Tumor Immune Evasion by Binding PARP1 and
            Upregulating Stat3-Induced Expression of PD-L1 in Multiple Cancers.
REFERENCE   2  (residues 1 to 770)
  AUTHORS   Ramos RB, Martino N, Chuy D, Lu S, Zuo MXG, Balasubramanian U, Di
            John Portela I, Vincent PA and Adam AP.
  TITLE     Shock drives a STAT3 and JunB-mediated coordinated transcriptional
            and DNA methylation response in the endothelium
  JOURNAL   J Cell Sci 136 (18) (2023)
   PUBMED   37667913
  REMARK    GeneRIF: Shock drives a STAT3 and JunB-mediated coordinated
            transcriptional and DNA methylation response in the endothelium.
REFERENCE   3  (residues 1 to 770)
  AUTHORS   Liu L, Xu W, Li K, Hu Y, Shen L, Zhang H and Wang Y.
  TITLE     Kv1.3 mediates ox-LDL-induced vascular smooth muscle cell
            proliferation through JAK2/STAT3 signaling pathway
  JOURNAL   Arch Biochem Biophys 746, 109719 (2023)
   PUBMED   37591369
  REMARK    GeneRIF: Kv1.3 mediates ox-LDL-induced vascular smooth muscle cell
            proliferation through JAK2/STAT3 signaling pathway.
REFERENCE   4  (residues 1 to 770)
  AUTHORS   Xu F, Lu S, Jia X and Zhou Y.
  TITLE     Bromodomain protein 4 mediates the roles of TGFbeta1-induced Stat3
            signaling in mouse liver fibrogenesis
  JOURNAL   Toxicol Lett 385, 42-50 (2023)
   PUBMED   37634812
  REMARK    GeneRIF: Bromodomain protein 4 mediates the roles of
            TGFbeta1-induced Stat3 signaling in mouse liver fibrogenesis.
REFERENCE   5  (residues 1 to 770)
  AUTHORS   Pencik J, Philippe C, Schlederer M, Atas E, Pecoraro M,
            Grund-Groschke S, Li WJ, Tracz A, Heidegger I, Lagger S, Trachtova
            K, Oberhuber M, Heitzer E, Aksoy O, Neubauer HA, Wingelhofer B,
            Orlova A, Witzeneder N, Dillinger T, Redl E, Greiner G, D'Andrea D,
            Ostman JR, Tangermann S, Hermanova I, Schafer G, Sternberg F, Pohl
            EE, Sternberg C, Varady A, Horvath J, Stoiber D, Malcolm TI, Turner
            SD, Parkes EE, Hantusch B, Egger G, Rose-John S, Poli V, Jain S,
            Armstrong CWD, Hoermann G, Goffin V, Aberger F, Moriggl R,
            Carracedo A, McKinney C, Kennedy RD, Klocker H, Speicher MR, Tang
            DG, Moazzami AA, Heery DM, Hacker M and Kenner L.
  TITLE     STAT3/LKB1 controls metastatic prostate cancer by regulating
            mTORC1/CREB pathway
  JOURNAL   Mol Cancer 22 (1), 133 (2023)
   PUBMED   37573301
  REMARK    GeneRIF: STAT3/LKB1 controls metastatic prostate cancer by
            regulating mTORC1/CREB pathway.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 770)
  AUTHORS   Schaefer TS, Sanders LK and Nathans D.
  TITLE     Cooperative transcriptional activity of Jun and Stat3 beta, a short
            form of Stat3
  JOURNAL   Proc Natl Acad Sci U S A 92 (20), 9097-9101 (1995)
   PUBMED   7568080
REFERENCE   7  (residues 1 to 770)
  AUTHORS   Wen Z, Zhong Z and Darnell JE Jr.
  TITLE     Maximal activation of transcription by Stat1 and Stat3 requires
            both tyrosine and serine phosphorylation
  JOURNAL   Cell 82 (2), 241-250 (1995)
   PUBMED   7543024
REFERENCE   8  (residues 1 to 770)
  AUTHORS   Raz R, Durbin JE and Levy DE.
  TITLE     Acute phase response factor and additional members of the
            interferon-stimulated gene factor 3 family integrate diverse
            signals from cytokines, interferons, and growth factors
  JOURNAL   J Biol Chem 269 (39), 24391-24395 (1994)
   PUBMED   7523373
REFERENCE   9  (residues 1 to 770)
  AUTHORS   Zhong Z, Wen Z and Darnell JE Jr.
  TITLE     Stat3 and Stat4: members of the family of signal transducers and
            activators of transcription
  JOURNAL   Proc Natl Acad Sci U S A 91 (11), 4806-4810 (1994)
   PUBMED   7545930
REFERENCE   10 (residues 1 to 770)
  AUTHORS   Akira S, Nishio Y, Inoue M, Wang XJ, Wei S, Matsusaka T, Yoshida K,
            Sudo T, Naruto M and Kishimoto T.
  TITLE     Molecular cloning of APRF, a novel IFN-stimulated gene factor 3
            p91-related transcription factor involved in the gp130-mediated
            signaling pathway
  JOURNAL   Cell 77 (1), 63-71 (1994)
   PUBMED   7512451
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL591466.8, AK145486.1,
            AA123454.1 and AK153170.1.
            
            Summary: The protein encoded by this gene is a member of the STAT
            protein family. In response to cytokines and growth factors, STAT
            family members are phosphorylated by the receptor associated
            kinases, and then form homo- or heterodimers that translocate to
            the cell nucleus where they act as transcription activators. This
            protein is activated through phosphorylation in response to various
            cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF,
            LIF and BMP2. This protein mediates the expression of a variety of
            genes in response to cell stimuli, and thus plays a key role in
            many cellular processes such as cell growth and apoptosis. The
            small GTPase Rac1 has been shown to bind and regulate the activity
            of this protein. PIAS3 protein is a specific inhibitor of this
            protein. Alternative splicing results in multiple transcript
            variants encoding distinct isoforms. [provided by RefSeq, Sep
            2015].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK153472.1, AK153005.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..770
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 63.82 cM"
     Protein         1..770
                     /product="signal transducer and activator of transcription
                     3 isoform 1"
                     /note="acute phase response factor"
                     /calculated_mol_wt=87923
     Region          2..120
                     /region_name="STAT_int"
                     /note="STAT protein, protein interaction domain;
                     smart00964"
                     /db_xref="CDD:214942"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:P40763; propagated from
                     UniProtKB/Swiss-Prot (P42227.2)"
     Region          139..318
                     /region_name="STAT3_CCD"
                     /note="Coiled-coil domain of Signal Transducer and
                     Activator of Transcription 3 (STAT3); cd16853"
                     /db_xref="CDD:341078"
     Site            order(142..165,213..239,263..284)
                     /site_type="other"
                     /note="coiled-coil motif"
                     /db_xref="CDD:341078"
     Region          150..162
                     /region_name="Essential for nuclear import"
                     /note="propagated from UniProtKB/Swiss-Prot (P42227.2)"
     Site            214..215
                     /site_type="other"
                     /note="ligand inducing"
                     /db_xref="CDD:341078"
     Site            order(243,245,247..248,251..252,260..261,264,267..268,
                     271..272,275,278..279,313..314)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:341078"
     Region          321..484
                     /region_name="STAT3_DBD"
                     /note="DNA-binding domain of Signal Transducer and
                     Activator of Transcription 3 (STAT3); cd16847"
                     /db_xref="CDD:341085"
     Site            order(382,417,432,465..466,469)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:341085"
     Region          554..715
                     /region_name="SH2_STAT3"
                     /note="Src homology 2 (SH2) domain found in signal
                     transducer and activator of transcription (STAT) 3
                     proteins; cd10374"
                     /db_xref="CDD:198237"
     Site            order(591,609,636,638)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198237"
     Site            601
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P40763; propagated from
                     UniProtKB/Swiss-Prot (P42227.2)"
     Site            615
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P40763; propagated from
                     UniProtKB/Swiss-Prot (P42227.2)"
     Site            631
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P40763; propagated from
                     UniProtKB/Swiss-Prot (P42227.2)"
     Site            order(637,653)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198237"
     Site            order(647..648,710)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:198237"
     Site            685
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P40763; propagated from
                     UniProtKB/Swiss-Prot (P42227.2)"
     Site            705
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by FER and PTK6.
                     /evidence=ECO:0000269|PubMed:11294897,
                     ECO:0000269|PubMed:11553624, ECO:0007744|PubMed:18034455;
                     propagated from UniProtKB/Swiss-Prot (P42227.2)"
     Site            707
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P40763; propagated from
                     UniProtKB/Swiss-Prot (P42227.2)"
     Site            714
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P42227.2)"
     Site            727
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by DYRK2, NLK, NEK6, IRAK1, RPS6KA5,
                     ZIPK/DAPK3 and PKC/PRKCE.
                     /evidence=ECO:0000305|PubMed:11553624,
                     ECO:0000305|PubMed:15004007, ECO:0000305|PubMed:20595392,
                     ECO:0000305|PubMed:7543024, ECO:0007744|PubMed:21183079;
                     propagated from UniProtKB/Swiss-Prot (P42227.2)"
     CDS             1..770
                     /gene="Stat3"
                     /gene_synonym="1110034C02Rik; Aprf"
                     /coded_by="NM_213659.3:309..2621"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS25440.1"
                     /db_xref="GeneID:20848"
                     /db_xref="MGI:MGI:103038"
ORIGIN      
        1 maqwnqlqql dtryleqlhq lysdsfpmel rqflapwies qdwayaaske shatlvfhnl
       61 lgeidqqysr flqesnvlyq hnlrrikqfl qsrylekpme iarivarclw eesrllqtaa
      121 taaqqggqan hptaavvtek qqmleqhlqd vrkrvqdleq kmkvvenlqd dfdfnyktlk
      181 sqgdmqdlng nnqsvtrqkm qqleqmltal dqmrrsivse lagllsamey vqktltdeel
      241 adwkrrqqia ciggppnicl drlenwitsl aesqlqtrqq ikkleelqqk vsykgdpivq
      301 hrpmleeriv elfrnlmksa fvverqpcmp mhpdrplvik tgvqfttkvr llvkfpelny
      361 qlkikvcidk dsgdvaalrg srkfnilgtn tkvmnmeesn ngslsaefkh ltlreqrcgn
      421 ggrancdasl ivteelhlit fetevyhqgl kidlethslp vvvisnicqm pnawasilwy
      481 nmltnnpknv nfftkppigt wdqvaevlsw qfssttkrgl sieqlttlae kllgpgvnys
      541 gcqitwakfc kenmagkgfs fwvwldniid lvkkyilalw negyimgfis kererailst
      601 kppgtfllrf sesskeggvt ftwvekdisg ktqiqsvepy tkqqlnnmsf aeiimgykim
      661 datnilvspl vylypdipke eafgkycrpe sqehpeadpg saapylktkf icvtpttcsn
      721 tidlpmsprt ldslmqfgnn gegaepsagg qfesltfdmd ltsecatspm
//
LOCUS       NP_033134                484 aa            linear   ROD 09-OCT-2023
DEFINITION  bile acid receptor isoform 3 [Mus musculus].
ACCESSION   NP_033134
VERSION     NP_033134.2
DBSOURCE    REFSEQ: accession NM_009108.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 484)
  AUTHORS   Xu Z, Huang Z, Zhang Y, Sun H, Hinz U, Heger U, Loos M, Gonzalez
            FJ, Hackert T, Bergmann F and Fortunato F.
  TITLE     Farnesoid X receptor activation inhibits pancreatic carcinogenesis
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1869 (7), 166811 (2023)
   PUBMED   37515840
REFERENCE   2  (residues 1 to 484)
  AUTHORS   Qiu Y, Kang N, Wang X, Yao Y, Cui J, Zhang X and Zheng L.
  TITLE     Loss of Farnesoid X receptor (FXR) accelerates dysregulated glucose
            and renal injury in db/db mice
  JOURNAL   PeerJ 11, e16155 (2023)
   PUBMED   37790634
  REMARK    GeneRIF: Loss of Farnesoid X receptor (FXR) accelerates
            dysregulated glucose and renal injury in db/db mice.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 484)
  AUTHORS   Dean AE, Jungwirth E, Panzitt K, Wagner M and Anakk S.
  TITLE     Hepatic farnesoid X receptor is necessary to facilitate ductular
            reaction and expression of heme biosynthetic genes
  JOURNAL   Hepatol Commun 7 (10), e0213 (2023)
   PUBMED   37695073
  REMARK    GeneRIF: Hepatic farnesoid X receptor is necessary to facilitate
            ductular reaction and expression of heme biosynthetic genes.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 484)
  AUTHORS   Li Z, Dong H, Bian S, Wu H, Song W, Jia X, Chen J, Zhu X, Zhao L,
            Xuan Z, Jin C, Zhou M, Zheng S and Song P.
  TITLE     FXR Maintains the Intestinal Barrier and Stemness by Regulating
            CYP11A1-Mediated Corticosterone Synthesis in Biliary Obstruction
            Diseases
  JOURNAL   Int J Mol Sci 24 (17), 13494 (2023)
   PUBMED   37686300
  REMARK    GeneRIF: FXR Maintains the Intestinal Barrier and Stemness by
            Regulating CYP11A1-Mediated Corticosterone Synthesis in Biliary
            Obstruction Diseases.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 484)
  AUTHORS   Song X, Zhang H, Zhang Y, Goh B, Bao B, Mello SS, Sun X, Zheng W,
            Gazzaniga FS, Wu M, Qu F, Yin Q, Gilmore MS, Oh SF and Kasper DL.
  TITLE     Gut microbial fatty acid isomerization modulates intraepithelial T
            cells
  JOURNAL   Nature 619 (7971), 837-843 (2023)
   PUBMED   37380774
REFERENCE   6  (residues 1 to 484)
  AUTHORS   Shih DQ, Bussen M, Sehayek E, Ananthanarayanan M, Shneider BL,
            Suchy FJ, Shefer S, Bollileni JS, Gonzalez FJ, Breslow JL and
            Stoffel M.
  TITLE     Hepatocyte nuclear factor-1alpha is an essential regulator of bile
            acid and plasma cholesterol metabolism
  JOURNAL   Nat Genet 27 (4), 375-382 (2001)
   PUBMED   11279518
REFERENCE   7  (residues 1 to 484)
  AUTHORS   Lammert F, Carey MC and Paigen B.
  TITLE     Chromosomal organization of candidate genes involved in cholesterol
            gallstone formation: a murine gallstone map
  JOURNAL   Gastroenterology 120 (1), 221-238 (2001)
   PUBMED   11208732
  REMARK    Review article
REFERENCE   8  (residues 1 to 484)
  AUTHORS   Sinal CJ, Tohkin M, Miyata M, Ward JM, Lambert G and Gonzalez FJ.
  TITLE     Targeted disruption of the nuclear receptor FXR/BAR impairs bile
            acid and lipid homeostasis
  JOURNAL   Cell 102 (6), 731-744 (2000)
   PUBMED   11030617
REFERENCE   9  (residues 1 to 484)
  AUTHORS   Kozak CA, Adamson MC and Weinberger C.
  TITLE     Genetic mapping of gene encoding the farnesoid receptor, Fxr, to
            mouse Chromosome 10
  JOURNAL   Mamm Genome 7 (2), 164-165 (1996)
   PUBMED   8835541
REFERENCE   10 (residues 1 to 484)
  AUTHORS   Seol W, Choi HS and Moore DD.
  TITLE     Isolation of proteins that interact specifically with the retinoid
            X receptor: two novel orphan receptors
  JOURNAL   Mol Endocrinol 9 (1), 72-85 (1995)
   PUBMED   7760852
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC152417.3 and AK132255.1.
            
            On Jul 30, 2009 this sequence version replaced NP_033134.1.
            
            Transcript Variant: This variant (3), alternatively referred to as
            beta 2 and alpha 4, uses an alternate in-frame splice site in the
            coding region, compared to variant 1. This results in a shorter
            isoform (2), compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132255.1, U09416.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..484
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 44.98 cM"
     Protein         1..484
                     /product="bile acid receptor isoform 3"
                     /note="bile acid receptor; farnesoid X activated receptor;
                     RXR-interacting protein 14; retinoid X
                     receptor-interacting protein 14; farnesol receptor HRR-1"
                     /calculated_mol_wt=55411
     Region          135..218
                     /region_name="NR_DBD_FXR"
                     /note="DNA-binding domain of Farnesoid X receptor (FXR)
                     family is composed of two C4-type zinc fingers; cd06962"
                     /db_xref="CDD:143520"
     Site            order(138,141,155,158,174,180,190,193)
                     /site_type="other"
                     /note="zinc binding site [ion binding]"
                     /db_xref="CDD:143520"
     Site            order(143..144,184..185,188)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:143520"
     Site            146
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKC/PRKCA.
                     /evidence=ECO:0000250|UniProtKB:Q96RI1; propagated from
                     UniProtKB/Swiss-Prot (Q60641.3)"
     Site            order(147..150,156..157,159,161,163..164,187..189,191,194,
                     208)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143520"
     Site            165
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKC/PRKCA.
                     /evidence=ECO:0000250|UniProtKB:Q96RI1; propagated from
                     UniProtKB/Swiss-Prot (Q60641.3)"
     Site            168
                     /site_type="acetylation"
                     /note="N6-acetyllysine, by EP300.
                     /evidence=ECO:0000250|UniProtKB:Q96RI1; propagated from
                     UniProtKB/Swiss-Prot (Q60641.3)"
     Site            217
                     /site_type="methylation"
                     /note="N6-methyllysine, by SETD7.
                     /evidence=ECO:0000250|UniProtKB:Q96RI1; propagated from
                     UniProtKB/Swiss-Prot (Q60641.3)"
     Site            224
                     /site_type="acetylation"
                     /note="N6-acetyllysine, by EP300.
                     /evidence=ECO:0000250|UniProtKB:Q96RI1; propagated from
                     UniProtKB/Swiss-Prot (Q60641.3)"
     Region          260..479
                     /region_name="NR_LBD_Fxr"
                     /note="The ligand binding domain of Farnesoid X receptor:a
                     member of the nuclear receptor superfamily of
                     ligand-activated transcription factors; cd06936"
                     /db_xref="CDD:132734"
     Site            order(277,296,299..300,302..303,306,340..341,343..344,347,
                     459,473)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:132734"
     Site            order(308,311,315,325..326,329,332..333,476,479)
                     /site_type="other"
                     /note="coactivator recognition site [polypeptide binding]"
                     /db_xref="CDD:132734"
     Site            order(387,406,413,417,440,443..444,447..448,450,453..454,
                     457..458)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:132734"
     Site            454
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by PKC/PRKCZ.
                     /evidence=ECO:0000250|UniProtKB:Q96RI1; propagated from
                     UniProtKB/Swiss-Prot (Q60641.3)"
     CDS             1..484
                     /gene="Nr1h4"
                     /gene_synonym="Fxr; HRR1; RIP14; Rxrip14"
                     /coded_by="NM_009108.2:43..1497"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS24116.1"
                     /db_xref="GeneID:20186"
                     /db_xref="MGI:MGI:1352464"
ORIGIN      
        1 mvmqfqglen piqislhhsh rlsgfvpegm svkpakgmlt ehaagplgqn ldlesyspyn
       61 nvpfpqvqpq issssyysnl gfypqqpedw yspgiyelrr mpaetgyqge tevsempvtk
      121 kprmaaasag rikgdelcvv cgdrasgyhy naltcegckg ffrrsitkna vykcknggnc
      181 vmdmymrrkc qecrlrkcke mgmlaecllt eiqckskrlr knvkqhadqt aneddsegrd
      241 lrqvtsttkf crekteltad qqtlldyimd synkqrmpqe itnkilkeef saeenflilt
      301 ematshvqil veftkklpgf qtldhedqia llkgsaveam flrsaeifnk klpaghadll
      361 eerirksgis deyitpmfsf yksvgelkmt qeeyalltai vilspdrqyi kdreaveklq
      421 eplldvlqkl ckmyqpenpq hfacllgrlt elrtfnhhha emlmswrvnd hkftpllcei
      481 wdvq
//
LOCUS       NP_001103675             509 aa            linear   ROD 09-OCT-2023
DEFINITION  activin receptor type-1 precursor [Mus musculus].
ACCESSION   NP_001103675
VERSION     NP_001103675.1
DBSOURCE    REFSEQ: accession NM_001110205.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 509)
  AUTHORS   Yang YS, Lin C, Ma H, Xie J, Kaplan FS, Gao G and Shim JH.
  TITLE     AAV-Mediated Targeting of the Activin A-ACVR1R206H Signaling in
            Fibrodysplasia Ossificans Progressiva
  JOURNAL   Biomolecules 13 (9), 1364 (2023)
   PUBMED   37759764
  REMARK    GeneRIF: AAV-Mediated Targeting of the Activin A-ACVR1[R206H]
            Signaling in Fibrodysplasia Ossificans Progressiva.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 509)
  AUTHORS   Yamaguchi H, Shen J, Little DR, Li M, Sozen S, Suzuki K, Mishina Y
            and Komatsu Y.
  TITLE     Enhanced BMP signaling through ALK2 attenuates keratinocyte
            differentiation
  JOURNAL   Biochem Biophys Res Commun 629, 101-105 (2022)
   PUBMED   36116371
  REMARK    GeneRIF: Enhanced BMP signaling through ALK2 attenuates
            keratinocyte differentiation.
REFERENCE   3  (residues 1 to 509)
  AUTHORS   Yamamoto M, Stoessel SJ, Yamamoto S and Goldhamer DJ.
  TITLE     Overexpression of Wild-Type ACVR1 in Fibrodysplasia Ossificans
            Progressiva Mice Rescues Perinatal Lethality and Inhibits
            Heterotopic Ossification
  JOURNAL   J Bone Miner Res 37 (11), 2077-2093 (2022)
   PUBMED   35637634
  REMARK    GeneRIF: Overexpression of Wild-Type ACVR1 in Fibrodysplasia
            Ossificans Progressiva Mice Rescues Perinatal Lethality and
            Inhibits Heterotopic Ossification.
REFERENCE   4  (residues 1 to 509)
  AUTHORS   Lees-Shepard JB, Stoessel SJ, Chandler JT, Bouchard K, Bento P,
            Apuzzo LN, Devarakonda PM, Hunter JW and Goldhamer DJ.
  TITLE     An anti-ACVR1 antibody exacerbates heterotopic ossification by
            fibro-adipogenic progenitors in fibrodysplasia ossificans
            progressiva mice
  JOURNAL   J Clin Invest 132 (12) (2022)
   PUBMED   35503416
REFERENCE   5  (residues 1 to 509)
  AUTHORS   Chen HY, Hu Y, Xu XB, Zhou YA, Li NS, He C, Xie C, Lu NH and Zhu Y.
  TITLE     Upregulation of oncogene Activin A receptor type I by Helicobacter
            pylori infection promotes gastric intestinal metaplasia via
            regulating CDX2
  JOURNAL   Helicobacter 26 (6), e12849 (2021)
   PUBMED   34490965
  REMARK    GeneRIF: Upregulation of oncogene Activin A receptor type I by
            Helicobacter pylori infection promotes gastric intestinal
            metaplasia via regulating CDX2.
REFERENCE   6  (residues 1 to 509)
  AUTHORS   Schmitt J, Mielke R and Schrewe H.
  TITLE     Genomic organization of a mouse type I activin receptor
  JOURNAL   Biochem Biophys Res Commun 213 (1), 211-217 (1995)
   PUBMED   7639738
REFERENCE   7  (residues 1 to 509)
  AUTHORS   Verschueren K, Dewulf N, Goumans MJ, Lonnoy O, Feijen A, Grimsby S,
            Vandi Spiegle K, ten Dijke P, Moren A, Vanscheeuwijck P, Heldin CH,
            Miyazono K, Mummery C, Van Den Eijnden-Van Raaij J and Huylebroeck
            D.
  TITLE     Expression of type I and type IB receptors for activin in
            midgestation mouse embryos suggests distinct functions in
            organogenesis
  JOURNAL   Mech Dev 52 (1), 109-123 (1995)
   PUBMED   7577669
REFERENCE   8  (residues 1 to 509)
  AUTHORS   Roelen BA, Lin HY, Knezevic V, Freund E and Mummery CL.
  TITLE     Expression of TGF-beta s and their receptors during implantation
            and organogenesis of the mouse embryo
  JOURNAL   Dev Biol 166 (2), 716-728 (1994)
   PUBMED   7813789
REFERENCE   9  (residues 1 to 509)
  AUTHORS   Nakamura T, Sugino K, Kurosawa N, Sawai M, Takio K, Eto Y, Iwashita
            S, Muramatsu M, Titani K and Sugino H.
  TITLE     Isolation and characterization of activin receptor from mouse
            embryonal carcinoma cells. Identification of its
            serine/threonine/tyrosine protein kinase activity
  JOURNAL   J Biol Chem 267 (26), 18924-18928 (1992)
   PUBMED   1326537
REFERENCE   10 (residues 1 to 509)
  AUTHORS   Mathews LS and Vale WW.
  TITLE     Expression cloning of an activin receptor, a predicted
            transmembrane serine kinase
  JOURNAL   Cell 65 (6), 973-982 (1991)
   PUBMED   1646080
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            L15436.1, BC058718.1 and BQ030975.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. All five variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L15436.1, SRR7345562.1940085.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 33.05 cM"
     Protein         1..509
                     /product="activin receptor type-1 precursor"
                     /EC_number="2.7.11.30"
                     /note="activin receptor type-1; TSR-I; TSK-7L; activin
                     receptor type I; TGF-B superfamily receptor type I;
                     serine/threonine-protein kinase receptor R1"
                     /calculated_mol_wt=55077
     sig_peptide     1..20
                     /note="/evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (P37172.2)"
                     /calculated_mol_wt=2167
     mat_peptide     21..509
                     /product="Activin receptor type-1. /id=PRO_0000024395"
                     /note="propagated from UniProtKB/Swiss-Prot (P37172.2)"
                     /calculated_mol_wt=55077
     Region          33..103
                     /region_name="Activin_recp"
                     /note="Activin types I and II receptor domain; pfam01064"
                     /db_xref="CDD:426025"
     Site            102
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P37172.2)"
     Site            124..146
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P37172.2)"
     Region          179..206
                     /region_name="TGF_beta_GS"
                     /note="Transforming growth factor beta type I GS-motif;
                     pfam08515"
                     /db_xref="CDD:430045"
     Region          202..499
                     /region_name="STKc_ACVR1_ALK1"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     Activin Type I Receptor and Activin receptor-Like Kinase
                     1; cd14142"
                     /db_xref="CDD:271044"
     Site            order(202..203,206..207,245..246,249..250,253..254,268,
                     270)
                     /site_type="other"
                     /note="FKBP12 binding site [polypeptide binding]"
                     /db_xref="CDD:271044"
     Site            order(214..218,222,233,235,263,283..286,290,292,336,338,
                     340..341,343,354,357,377..380)
                     /site_type="active"
                     /db_xref="CDD:271044"
     Site            order(214..220,222,233,235,283..284,286,290,340..341,343,
                     354)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271044"
     Site            order(218,290,292,336,338,340,357,377..380)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:271044"
     Site            353..380
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:271044"
     Site            501
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04771; propagated from
                     UniProtKB/Swiss-Prot (P37172.2)"
     CDS             1..509
                     /gene="Acvr1"
                     /gene_synonym="ActR-I; ActRIA; Acvr; Acvr1a; Acvrlk2;
                     Alk-2; ALK2; Alk8; D330013D15Rik; SKR1; Tsk7L"
                     /coded_by="NM_001110205.1:146..1675"
                     /db_xref="CCDS:CCDS16050.1"
                     /db_xref="GeneID:11477"
                     /db_xref="MGI:MGI:87911"
ORIGIN      
        1 mvdgvmilpv lmmmafpsps vedekpkvnq klymcvcegl scgnedhceg qqcfsslsin
       61 dgfhvyqkgc fqvyeqgkmt cktppspgqa veccqgdwcn rnitaqlptk gksfpgtqnf
      121 hlevgliils vvfavcllac ilgvalrkfk rrnqerlnpr dveygtiegl ittnvgdstl
      181 aelldhscts gsgsglpflv qrtvarqitl lecvgkgryg evwrgswqge nvavkifssr
      241 dekswfrete lyntvmlrhe nilgfiasdm tsrhsstqlw lithyhemgs lydylqlttl
      301 dtvsclrivl siasglahlh ieifgtqgks aiahrdlksk nilvkkngqc ciadlglavm
      361 hsqstnqldv gnnprvgtkr ymapevldet iqvdcfdsyk rvdiwafglv lwevarrmvs
      421 ngivedykpp fydvvpndps fedmrkvvcv dqqrpnipnr wfsdptltsl aklmkecwyq
      481 npsarltalr ikktltkidn sldklktdc
//
LOCUS       NP_001157172             488 aa            linear   ROD 09-OCT-2023
DEFINITION  bile acid receptor isoform 1 [Mus musculus].
ACCESSION   NP_001157172
VERSION     NP_001157172.1
DBSOURCE    REFSEQ: accession NM_001163700.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 488)
  AUTHORS   Xu Z, Huang Z, Zhang Y, Sun H, Hinz U, Heger U, Loos M, Gonzalez
            FJ, Hackert T, Bergmann F and Fortunato F.
  TITLE     Farnesoid X receptor activation inhibits pancreatic carcinogenesis
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1869 (7), 166811 (2023)
   PUBMED   37515840
REFERENCE   2  (residues 1 to 488)
  AUTHORS   Qiu Y, Kang N, Wang X, Yao Y, Cui J, Zhang X and Zheng L.
  TITLE     Loss of Farnesoid X receptor (FXR) accelerates dysregulated glucose
            and renal injury in db/db mice
  JOURNAL   PeerJ 11, e16155 (2023)
   PUBMED   37790634
  REMARK    GeneRIF: Loss of Farnesoid X receptor (FXR) accelerates
            dysregulated glucose and renal injury in db/db mice.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 488)
  AUTHORS   Dean AE, Jungwirth E, Panzitt K, Wagner M and Anakk S.
  TITLE     Hepatic farnesoid X receptor is necessary to facilitate ductular
            reaction and expression of heme biosynthetic genes
  JOURNAL   Hepatol Commun 7 (10), e0213 (2023)
   PUBMED   37695073
  REMARK    GeneRIF: Hepatic farnesoid X receptor is necessary to facilitate
            ductular reaction and expression of heme biosynthetic genes.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 488)
  AUTHORS   Li Z, Dong H, Bian S, Wu H, Song W, Jia X, Chen J, Zhu X, Zhao L,
            Xuan Z, Jin C, Zhou M, Zheng S and Song P.
  TITLE     FXR Maintains the Intestinal Barrier and Stemness by Regulating
            CYP11A1-Mediated Corticosterone Synthesis in Biliary Obstruction
            Diseases
  JOURNAL   Int J Mol Sci 24 (17), 13494 (2023)
   PUBMED   37686300
  REMARK    GeneRIF: FXR Maintains the Intestinal Barrier and Stemness by
            Regulating CYP11A1-Mediated Corticosterone Synthesis in Biliary
            Obstruction Diseases.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 488)
  AUTHORS   Song X, Zhang H, Zhang Y, Goh B, Bao B, Mello SS, Sun X, Zheng W,
            Gazzaniga FS, Wu M, Qu F, Yin Q, Gilmore MS, Oh SF and Kasper DL.
  TITLE     Gut microbial fatty acid isomerization modulates intraepithelial T
            cells
  JOURNAL   Nature 619 (7971), 837-843 (2023)
   PUBMED   37380774
REFERENCE   6  (residues 1 to 488)
  AUTHORS   Shih DQ, Bussen M, Sehayek E, Ananthanarayanan M, Shneider BL,
            Suchy FJ, Shefer S, Bollileni JS, Gonzalez FJ, Breslow JL and
            Stoffel M.
  TITLE     Hepatocyte nuclear factor-1alpha is an essential regulator of bile
            acid and plasma cholesterol metabolism
  JOURNAL   Nat Genet 27 (4), 375-382 (2001)
   PUBMED   11279518
REFERENCE   7  (residues 1 to 488)
  AUTHORS   Lammert F, Carey MC and Paigen B.
  TITLE     Chromosomal organization of candidate genes involved in cholesterol
            gallstone formation: a murine gallstone map
  JOURNAL   Gastroenterology 120 (1), 221-238 (2001)
   PUBMED   11208732
  REMARK    Review article
REFERENCE   8  (residues 1 to 488)
  AUTHORS   Sinal CJ, Tohkin M, Miyata M, Ward JM, Lambert G and Gonzalez FJ.
  TITLE     Targeted disruption of the nuclear receptor FXR/BAR impairs bile
            acid and lipid homeostasis
  JOURNAL   Cell 102 (6), 731-744 (2000)
   PUBMED   11030617
REFERENCE   9  (residues 1 to 488)
  AUTHORS   Kozak CA, Adamson MC and Weinberger C.
  TITLE     Genetic mapping of gene encoding the farnesoid receptor, Fxr, to
            mouse Chromosome 10
  JOURNAL   Mamm Genome 7 (2), 164-165 (1996)
   PUBMED   8835541
REFERENCE   10 (residues 1 to 488)
  AUTHORS   Seol W, Choi HS and Moore DD.
  TITLE     Isolation of proteins that interact specifically with the retinoid
            X receptor: two novel orphan receptors
  JOURNAL   Mol Endocrinol 9 (1), 72-85 (1995)
   PUBMED   7760852
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC152417.3 and AK002513.1.
            
            Transcript Variant: This variant (1), alternatively referred to as
            beta 1 and alpha 3, encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK002513.1, SRR5189682.62501.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 44.98 cM"
     Protein         1..488
                     /product="bile acid receptor isoform 1"
                     /note="bile acid receptor; farnesoid X activated receptor;
                     RXR-interacting protein 14; retinoid X
                     receptor-interacting protein 14; farnesol receptor HRR-1"
                     /calculated_mol_wt=55863
     Region          135..222
                     /region_name="NR_DBD_FXR"
                     /note="DNA-binding domain of Farnesoid X receptor (FXR)
                     family is composed of two C4-type zinc fingers; cd06962"
                     /db_xref="CDD:143520"
     Site            order(138,141,155,158,174,180,190,193)
                     /site_type="other"
                     /note="zinc binding site [ion binding]"
                     /db_xref="CDD:143520"
     Site            order(143..144,184..185,188)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:143520"
     Site            146
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKC/PRKCA.
                     /evidence=ECO:0000250|UniProtKB:Q96RI1; propagated from
                     UniProtKB/Swiss-Prot (Q60641.3)"
     Site            order(147..150,156..157,159,161,163..164,187..189,191,194,
                     208)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143520"
     Site            165
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKC/PRKCA.
                     /evidence=ECO:0000250|UniProtKB:Q96RI1; propagated from
                     UniProtKB/Swiss-Prot (Q60641.3)"
     Site            168
                     /site_type="acetylation"
                     /note="N6-acetyllysine, by EP300.
                     /evidence=ECO:0000250|UniProtKB:Q96RI1; propagated from
                     UniProtKB/Swiss-Prot (Q60641.3)"
     Site            221
                     /site_type="methylation"
                     /note="N6-methyllysine, by SETD7.
                     /evidence=ECO:0000250|UniProtKB:Q96RI1; propagated from
                     UniProtKB/Swiss-Prot (Q60641.3)"
     Site            228
                     /site_type="acetylation"
                     /note="N6-acetyllysine, by EP300.
                     /evidence=ECO:0000250|UniProtKB:Q96RI1; propagated from
                     UniProtKB/Swiss-Prot (Q60641.3)"
     Region          264..483
                     /region_name="NR_LBD_Fxr"
                     /note="The ligand binding domain of Farnesoid X receptor:a
                     member of the nuclear receptor superfamily of
                     ligand-activated transcription factors; cd06936"
                     /db_xref="CDD:132734"
     Site            order(281,300,303..304,306..307,310,344..345,347..348,351,
                     463,477)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:132734"
     Site            order(312,315,319,329..330,333,336..337,480,483)
                     /site_type="other"
                     /note="coactivator recognition site [polypeptide binding]"
                     /db_xref="CDD:132734"
     Site            order(391,410,417,421,444,447..448,451..452,454,457..458,
                     461..462)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:132734"
     Site            458
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by PKC/PRKCZ.
                     /evidence=ECO:0000250|UniProtKB:Q96RI1; propagated from
                     UniProtKB/Swiss-Prot (Q60641.3)"
     CDS             1..488
                     /gene="Nr1h4"
                     /gene_synonym="Fxr; HRR1; RIP14; Rxrip14"
                     /coded_by="NM_001163700.1:43..1509"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS48668.1"
                     /db_xref="GeneID:20186"
                     /db_xref="MGI:MGI:1352464"
ORIGIN      
        1 mvmqfqglen piqislhhsh rlsgfvpegm svkpakgmlt ehaagplgqn ldlesyspyn
       61 nvpfpqvqpq issssyysnl gfypqqpedw yspgiyelrr mpaetgyqge tevsempvtk
      121 kprmaaasag rikgdelcvv cgdrasgyhy naltcegckg ffrrsitkna vykcknggnc
      181 vmdmymrrkc qecrlrkcke mgmlaecmyt gllteiqcks krlrknvkqh adqtanedds
      241 egrdlrqvts ttkfcrekte ltadqqtlld yimdsynkqr mpqeitnkil keefsaeenf
      301 liltematsh vqilveftkk lpgfqtldhe dqiallkgsa veamflrsae ifnkklpagh
      361 adlleerirk sgisdeyitp mfsfyksvge lkmtqeeyal ltaivilspd rqyikdreav
      421 eklqeplldv lqklckmyqp enpqhfacll grltelrtfn hhhaemlmsw rvndhkftpl
      481 lceiwdvq
//
LOCUS       NP_001349261             456 aa            linear   ROD 09-OCT-2023
DEFINITION  CUGBP Elav-like family member 4 isoform 50 [Mus musculus].
ACCESSION   NP_001349261 XP_017173288
VERSION     NP_001349261.1
DBSOURCE    REFSEQ: accession NM_001362332.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 456)
  AUTHORS   Salamon I, Park Y, Miskic T, Kopic J, Matteson P, Page NF, Roque A,
            McAuliffe GW, Favate J, Garcia-Forn M, Shah P, Judas M, Millonig
            JH, Kostovic I, De Rubeis S, Hart RP, Krsnik Z and Rasin MR.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    GeneRIF: Celf4 controls mRNA translation underlying synaptic
            development in the prenatal mammalian neocortex.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 456)
  AUTHORS   Shen Y, Zhang C, Xiao K, Liu D and Xie G.
  TITLE     CELF4 regulates spine formation and depression-like behaviors of
            mice
  JOURNAL   Biochem Biophys Res Commun 605, 39-44 (2022)
   PUBMED   35306363
  REMARK    GeneRIF: CELF4 regulates spine formation and depression-like
            behaviors of mice.
REFERENCE   3  (residues 1 to 456)
  AUTHORS   Moreau MX, Saillour Y, Cwetsch AW, Pierani A and Causeret F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   4  (residues 1 to 456)
  AUTHORS   Li C, Li X, Bi Z, Sugino K, Wang G, Zhu T and Liu Z.
  TITLE     Comprehensive transcriptome analysis of cochlear spiral ganglion
            neurons at multiple ages
  JOURNAL   Elife 9, e50491 (2020)
   PUBMED   31913118
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 456)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 456)
  AUTHORS   Ladd AN, Taffet G, Hartley C, Kearney DL and Cooper TA.
  TITLE     Cardiac tissue-specific repression of CELF activity disrupts
            alternative splicing and causes cardiomyopathy
  JOURNAL   Mol Cell Biol 25 (14), 6267-6278 (2005)
   PUBMED   15988035
  REMARK    GeneRIF: CELF protein activity is required for normal alternative
            splicing in the heart in vivo and normal CELF-mediated alternative
            splicing regulation is in turn required for normal cardiac
            function.
REFERENCE   7  (residues 1 to 456)
  AUTHORS   Meins M, Schlickum S, Wilhelm C, Missbach J, Yadav S, Glaser B,
            Grzmil M, Burfeind P and Laccone F.
  TITLE     Identification and characterization of murine Brunol4, a new member
            of the elav/bruno family
  JOURNAL   Cytogenet Genome Res 97 (3-4), 254-260 (2002)
   PUBMED   12438720
  REMARK    GeneRIF: cloning and characterization
REFERENCE   8  (residues 1 to 456)
  AUTHORS   Ladd AN, Charlet N and Cooper TA.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   9  (residues 1 to 456)
  AUTHORS   Good PJ, Chen Q, Warner SJ and Herring DC.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
REFERENCE   10 (residues 1 to 456)
  AUTHORS   Yulug IG, Egan SE, See CG and Fisher EM.
  TITLE     Mapping GRB2, a signal transduction gene in the human and the mouse
  JOURNAL   Genomics 22 (2), 313-318 (1994)
   PUBMED   7806216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121094.8 and AC144938.3.
            
            On Apr 12, 2018 this sequence version replaced XP_017173288.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.245280.1,
                                           SRR1660813.196395.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..456
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 13.92 cM"
     Protein         1..456
                     /product="CUGBP Elav-like family member 4 isoform 50"
                     /note="CUG-BP- and ETR-3-like factor 4; bruno-like protein
                     4; RNA-binding protein BRUNOL-4; bruno-like 4, RNA binding
                     protein"
                     /calculated_mol_wt=48431
     Region          49..135
                     /region_name="RRM1_CELF3_4_5_6"
                     /note="RNA recognition motif 1 (RRM1) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12632"
                     /db_xref="CDD:410041"
     Site            order(55,57,59..60,63,82,84,86,95..97,99,129,131)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410041"
     Region          150..230
                     /region_name="RRM2_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12635"
                     /db_xref="CDD:410043"
     Site            order(152,154,156..157,160,179,181,183,191..193,195,225,
                     227)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410043"
     Region          <415..455
                     /region_name="RRM_SF"
                     /note="RNA recognition motif (RRM) superfamily; cl17169"
                     /db_xref="CDD:450164"
     CDS             1..456
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /coded_by="NM_001362332.1:531..1901"
                     /note="isoform 50 is encoded by transcript variant 52"
                     /db_xref="GeneID:108013"
                     /db_xref="MGI:MGI:1932407"
ORIGIN      
        1 myikmatlan gqadnaslst nglgsspgsa ghmnglshsp gnpstipmkd hdaiklfigq
       61 iprnldekdl kplfeefgki yeltvlkdrf tgmhkgcafl tyceresalk aqsalheqkt
      121 lpgmnrpiqv kpadsesrgg ssclrqppsh rklfvgmlnk qqseddvrrl feafgnieec
      181 tilrgpdgns kgcafvkyss haeaqaaina lhgsqtmpga ssslvvkfad tdkertmrrm
      241 qqmagqmgmf npmaipfgay gayaqalmqq qaalmasvaq ggylnpmaaf aaaqmqqmaa
      301 lnmnglaaap mtptsggstp pgitapavps ipspigvngf tglppqangq paaeavfang
      361 ihpypaqspt aadplqqaya gvqqyagpay paaygqisqa fpqpppmipq qqregfvsfd
      421 npasaqtaiq amngfqigmk rlkvqlkrpk danrpy
//
LOCUS       NP_848904                514 aa            linear   ROD 09-OCT-2023
DEFINITION  transmembrane protein 117 [Mus musculus].
ACCESSION   NP_848904
VERSION     NP_848904.1
DBSOURCE    REFSEQ: accession NM_178789.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 514)
  AUTHORS   Yang Y, Wang X, Yan P, Wang D, Luo T, Zhou Y, Chen S, Liu Q, Hou J
            and Wang P.
  TITLE     Transmembrane protein 117 knockdown protects against
            angiotensin-II-induced cardiac hypertrophy
  JOURNAL   Hypertens Res 46 (10), 2326-2339 (2023)
   PUBMED   37488300
  REMARK    GeneRIF: Transmembrane protein 117 knockdown protects against
            angiotensin-II-induced cardiac hypertrophy.
REFERENCE   2  (residues 1 to 514)
  AUTHORS   Gaspari S, Labouebe G, Picard A, Berney X, Rodriguez
            Sanchez-Archidona A and Thorens B.
  TITLE     Tmem117 in AVP neurons regulates the counterregulatory response to
            hypoglycemia
  JOURNAL   EMBO Rep 24 (8), e57344 (2023)
   PUBMED   37314252
  REMARK    GeneRIF: Tmem117 in AVP neurons regulates the counterregulatory
            response to hypoglycemia.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC147160.2,
            AC158918.7, AC118683.10 and AC102905.9.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK047437.1, AK048597.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 48.65 cM"
     Protein         1..514
                     /product="transmembrane protein 117"
                     /calculated_mol_wt=60225
     Region          4..403
                     /region_name="TMEM117"
                     /note="TMEM117 protein family; pfam15113"
                     /db_xref="CDD:434469"
     Site            16..36
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BH18.1)"
     Site            66..86
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BH18.1)"
     Site            111..131
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BH18.1)"
     Site            155..175
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BH18.1)"
     Site            199..219
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BH18.1)"
     Site            240..260
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BH18.1)"
     Site            296..316
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BH18.1)"
     Site            353
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000250|UniProtKB:Q9H0C3; propagated from
                     UniProtKB/Swiss-Prot (Q8BH18.1)"
     Site            371
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000250|UniProtKB:Q9H0C3; propagated from
                     UniProtKB/Swiss-Prot (Q8BH18.1)"
     Site            395..415
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BH18.1)"
     Region          430..450
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BH18.1)"
     Site            453
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8BH18.1)"
     Region          494..514
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BH18.1)"
     CDS             1..514
                     /gene="Tmem117"
                     /gene_synonym="B930062P21Rik"
                     /coded_by="NM_178789.4:145..1689"
                     /db_xref="CCDS:CCDS27774.1"
                     /db_xref="GeneID:320709"
                     /db_xref="MGI:MGI:2444580"
ORIGIN      
        1 mgkdfryyfq hpwsrmivay lviffnflif aedpvshsqt eanvivvgnc fsfvtnkypr
       61 gvgwrilkvl lwllailigl iagkflfhqr lfgqllrlkm fredhgswmt mffstilflf
      121 ifshiyntil lmdgnmgayl itdymgirne sfmklaavgt wmgdfvtawm vtdmmlqdkp
      181 ypdwgksara fwkkgnvrii lfwtvlftlt svvvlvittd wiswdklnrg flpsdevsra
      241 flasfilvfd llivmqdwef phfmgdvdvn lpglhtphmq fkipffqkif keeyrihitg
      301 kwfnygiifl vlildlnmwk nqifykphey gqyigpgqki ytvkdseslk dlnrtklswe
      361 wrsnhtnpqt nktyvegdmf lhsrfigasl dvkclafvps liafvwfgff iwffgrflkn
      421 eqgmenqdkt ytrmkrksps ehskdmgitr entqvsvedp lndpalvcir sdfneivyks
      481 shltsenlsl hlkestseve aeqepaasqr mrtn
//
LOCUS       NP_001397152             534 aa            linear   ROD 09-OCT-2023
DEFINITION  nuclear respiratory factor 1 isoform b [Mus musculus].
ACCESSION   NP_001397152 XP_006505069
VERSION     NP_001397152.1
DBSOURCE    REFSEQ: accession NM_001410223.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 534)
  AUTHORS   Cheng C, Tian Y, Yang R, Guo W, Xiao K, Zhang F, Tian J, Deng Z,
            Yang W, Yang H and Zhou Z.
  TITLE     miR-5581 Contributes to Osteoarthritis by Targeting NRF1 to Disturb
            the Proliferation and Functions of Chondrocytes
  JOURNAL   Am J Pathol 193 (9), 1234-1247 (2023)
   PUBMED   37611970
  REMARK    GeneRIF: miR-5581 Contributes to Osteoarthritis by Targeting NRF1
            to Disturb the Proliferation and Functions of Chondrocytes.
REFERENCE   2  (residues 1 to 534)
  AUTHORS   Meng Z, Liang B, Wu Y, Liu C, Wang H, Du Y, Gan L, Gao E, Lau WB,
            Christopher TA, Lopez BL, Koch WJ, Ma X, Zhao F, Wang Y and Zhao J.
  TITLE     Hypoadiponectinemia-induced upregulation of microRNA449b
            downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury
            in diabetic mice
  JOURNAL   J Mol Cell Cardiol 182, 1-14 (2023)
   PUBMED   37437402
  REMARK    GeneRIF: Hypoadiponectinemia-induced upregulation of microRNA449b
            downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury
            in diabetic mice.
REFERENCE   3  (residues 1 to 534)
  AUTHORS   Zhao T, Zhang J, Lei H, Meng Y, Cheng H, Zhao Y, Geng G, Mu C, Chen
            L, Liu Q, Luo Q, Zhang C, Long Y, Su J, Wang Y, Li Z, Sun J, Chen
            G, Li Y, Liao X, Shang Y, Hu G, Chen Q and Zhu Y.
  TITLE     NRF1-mediated mitochondrial biogenesis antagonizes innate antiviral
            immunity
  JOURNAL   EMBO J 42 (16), e113258 (2023)
   PUBMED   37409632
  REMARK    GeneRIF: NRF1-mediated mitochondrial biogenesis antagonizes innate
            antiviral immunity.
REFERENCE   4  (residues 1 to 534)
  AUTHORS   Akl MG, Baccetto R, Stebbings BM, Li L and Widenmaier SB.
  TITLE     Euglycemia is affected by stress defense factor hepatocyte NRF1,
            but not NRF2
  JOURNAL   Biochem Biophys Res Commun 668, 96-103 (2023)
   PUBMED   37245295
  REMARK    GeneRIF: Euglycemia is affected by stress defense factor hepatocyte
            NRF1, but not NRF2.
REFERENCE   5  (residues 1 to 534)
  AUTHORS   Akl MG, Li L, Baccetto R, Phanse S, Zhang Q, Trites MJ, McDonald S,
            Aoki H, Babu M and Widenmaier SB.
  TITLE     Complementary gene regulation by NRF1 and NRF2 protects against
            hepatic cholesterol overload
  JOURNAL   Cell Rep 42 (4), 112399 (2023)
   PUBMED   37060561
  REMARK    GeneRIF: Complementary gene regulation by NRF1 and NRF2 protects
            against hepatic cholesterol overload.
            Erratum:[Cell Rep. 2023 Jul 25;42(7):112872. PMID: 37454293]
REFERENCE   6  (residues 1 to 534)
  AUTHORS   Carmona MC, Iglesias R, Obregon MJ, Darlington GJ, Villarroya F and
            Giralt M.
  TITLE     Mitochondrial biogenesis and thyroid status maturation in brown fat
            require CCAAT/enhancer-binding protein alpha
  JOURNAL   J Biol Chem 277 (24), 21489-21498 (2002)
   PUBMED   11940593
REFERENCE   7  (residues 1 to 534)
  AUTHORS   Huo L and Scarpulla RC.
  TITLE     Mitochondrial DNA instability and peri-implantation lethality
            associated with targeted disruption of nuclear respiratory factor 1
            in mice
  JOURNAL   Mol Cell Biol 21 (2), 644-654 (2001)
   PUBMED   11134350
REFERENCE   8  (residues 1 to 534)
  AUTHORS   Schaefer L, Engman H and Miller JB.
  TITLE     Coding sequence, chromosomal localization, and expression pattern
            of Nrf1: the mouse homolog of Drosophila erect wing
  JOURNAL   Mamm Genome 11 (2), 104-110 (2000)
   PUBMED   10656923
REFERENCE   9  (residues 1 to 534)
  AUTHORS   Huo L and Scarpulla RC.
  TITLE     Multiple 5'-untranslated exons in the nuclear respiratory factor 1
            gene span 47 kb and contribute to transcript heterogeneity and
            translational efficiency
  JOURNAL   Gene 233 (1-2), 213-224 (1999)
   PUBMED   10375638
REFERENCE   10 (residues 1 to 534)
  AUTHORS   Virbasius CA, Virbasius JV and Scarpulla RC.
  TITLE     NRF-1, an activator involved in nuclear-mitochondrial interactions,
            utilizes a new DNA-binding domain conserved in a family of
            developmental regulators
  JOURNAL   Genes Dev 7 (12A), 2431-2445 (1993)
   PUBMED   8253388
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134897.4 and AC153632.2.
            
            On Aug 1, 2022 this sequence version replaced XP_006505069.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.1498865.1,
                                           SRR12282455.21974378.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..534
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 12.47 cM"
     Protein         1..534
                     /product="nuclear respiratory factor 1 isoform b"
                     /note="NRF-1; alpha-pal; alpha palindromic-binding
                     protein"
                     /calculated_mol_wt=57152
     Region          1..78
                     /region_name="Dimerization. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU00.2)"
     Region          36..57
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU00.2)"
     Site            39
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:Q16656; propagated from
                     UniProtKB/Swiss-Prot (Q9WU00.2)"
     Site            44
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:Q16656; propagated from
                     UniProtKB/Swiss-Prot (Q9WU00.2)"
     Site            46
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:Q16656; propagated from
                     UniProtKB/Swiss-Prot (Q9WU00.2)"
     Site            47
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:Q16656; propagated from
                     UniProtKB/Swiss-Prot (Q9WU00.2)"
     Site            52
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:Q16656; propagated from
                     UniProtKB/Swiss-Prot (Q9WU00.2)"
     Region          87..283
                     /region_name="Nrf1_DNA-bind"
                     /note="NLS-binding and DNA-binding and dimerization
                     domains of Nrf1; pfam10491"
                     /db_xref="CDD:402218"
     Region          88..116
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU00.2)"
     Region          450..525
                     /region_name="TGS_YchF_OLA1"
                     /note="TGS (ThrRS, GTPase and SpoT) domain found in the
                     YchF/OLA1 family proteins; cd04867"
                     /db_xref="CDD:340516"
     CDS             1..534
                     /gene="Nrf1"
                     /gene_synonym="D6Ertd415e"
                     /coded_by="NM_001410223.1:295..1899"
                     /note="isoform b is encoded by transcript variant 13"
                     /db_xref="GeneID:18181"
                     /db_xref="MGI:MGI:1332235"
ORIGIN      
        1 meehgvtqte hmatieahav aqqvqqvhva tytehsmlsa dedspssped tsyddsdiln
       61 staadevtah laaagpvgma aaaavatgkk rkrphvfesn psirkrqqtr llrklratld
      121 eyttrvgqqa ivlcispskp npvfkvfgaa plenvvrkyk smiledlesa laehapapqe
      181 vnselpplti dgipvsvdkm tqaqlrafip emlkystgrg kpgwgkesck piwwpedipw
      241 anvrsdvrte eqkqrvswtq alrtivkncy kqhgredlly afedqqtqtq attthsiahl
      301 vpsqtvvqtf snpdgtvsli qvgtgatvat ladaselptt vtvaqvnysa vadgeveqnw
      361 atlqggemti qttqaseatq avaslaeaav aasqemqqga tvtmalnsea aahavatlae
      421 atlqgggqiv lsgetaaavg altgvqdang pdgvhawtis kavtapqaag kihtdfgkgf
      481 imaevmkded lkeessenaa kaagkykqqg rayvvedgdi iffkfnspqq lkkk
//
LOCUS       NP_001397161             481 aa            linear   ROD 09-OCT-2023
DEFINITION  nuclear respiratory factor 1 isoform j [Mus musculus].
ACCESSION   NP_001397161
VERSION     NP_001397161.1
DBSOURCE    REFSEQ: accession NM_001410232.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 481)
  AUTHORS   Cheng C, Tian Y, Yang R, Guo W, Xiao K, Zhang F, Tian J, Deng Z,
            Yang W, Yang H and Zhou Z.
  TITLE     miR-5581 Contributes to Osteoarthritis by Targeting NRF1 to Disturb
            the Proliferation and Functions of Chondrocytes
  JOURNAL   Am J Pathol 193 (9), 1234-1247 (2023)
   PUBMED   37611970
  REMARK    GeneRIF: miR-5581 Contributes to Osteoarthritis by Targeting NRF1
            to Disturb the Proliferation and Functions of Chondrocytes.
REFERENCE   2  (residues 1 to 481)
  AUTHORS   Meng Z, Liang B, Wu Y, Liu C, Wang H, Du Y, Gan L, Gao E, Lau WB,
            Christopher TA, Lopez BL, Koch WJ, Ma X, Zhao F, Wang Y and Zhao J.
  TITLE     Hypoadiponectinemia-induced upregulation of microRNA449b
            downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury
            in diabetic mice
  JOURNAL   J Mol Cell Cardiol 182, 1-14 (2023)
   PUBMED   37437402
  REMARK    GeneRIF: Hypoadiponectinemia-induced upregulation of microRNA449b
            downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury
            in diabetic mice.
REFERENCE   3  (residues 1 to 481)
  AUTHORS   Zhao T, Zhang J, Lei H, Meng Y, Cheng H, Zhao Y, Geng G, Mu C, Chen
            L, Liu Q, Luo Q, Zhang C, Long Y, Su J, Wang Y, Li Z, Sun J, Chen
            G, Li Y, Liao X, Shang Y, Hu G, Chen Q and Zhu Y.
  TITLE     NRF1-mediated mitochondrial biogenesis antagonizes innate antiviral
            immunity
  JOURNAL   EMBO J 42 (16), e113258 (2023)
   PUBMED   37409632
  REMARK    GeneRIF: NRF1-mediated mitochondrial biogenesis antagonizes innate
            antiviral immunity.
REFERENCE   4  (residues 1 to 481)
  AUTHORS   Akl MG, Baccetto R, Stebbings BM, Li L and Widenmaier SB.
  TITLE     Euglycemia is affected by stress defense factor hepatocyte NRF1,
            but not NRF2
  JOURNAL   Biochem Biophys Res Commun 668, 96-103 (2023)
   PUBMED   37245295
  REMARK    GeneRIF: Euglycemia is affected by stress defense factor hepatocyte
            NRF1, but not NRF2.
REFERENCE   5  (residues 1 to 481)
  AUTHORS   Akl MG, Li L, Baccetto R, Phanse S, Zhang Q, Trites MJ, McDonald S,
            Aoki H, Babu M and Widenmaier SB.
  TITLE     Complementary gene regulation by NRF1 and NRF2 protects against
            hepatic cholesterol overload
  JOURNAL   Cell Rep 42 (4), 112399 (2023)
   PUBMED   37060561
  REMARK    GeneRIF: Complementary gene regulation by NRF1 and NRF2 protects
            against hepatic cholesterol overload.
            Erratum:[Cell Rep. 2023 Jul 25;42(7):112872. PMID: 37454293]
REFERENCE   6  (residues 1 to 481)
  AUTHORS   Carmona MC, Iglesias R, Obregon MJ, Darlington GJ, Villarroya F and
            Giralt M.
  TITLE     Mitochondrial biogenesis and thyroid status maturation in brown fat
            require CCAAT/enhancer-binding protein alpha
  JOURNAL   J Biol Chem 277 (24), 21489-21498 (2002)
   PUBMED   11940593
REFERENCE   7  (residues 1 to 481)
  AUTHORS   Huo L and Scarpulla RC.
  TITLE     Mitochondrial DNA instability and peri-implantation lethality
            associated with targeted disruption of nuclear respiratory factor 1
            in mice
  JOURNAL   Mol Cell Biol 21 (2), 644-654 (2001)
   PUBMED   11134350
REFERENCE   8  (residues 1 to 481)
  AUTHORS   Schaefer L, Engman H and Miller JB.
  TITLE     Coding sequence, chromosomal localization, and expression pattern
            of Nrf1: the mouse homolog of Drosophila erect wing
  JOURNAL   Mamm Genome 11 (2), 104-110 (2000)
   PUBMED   10656923
REFERENCE   9  (residues 1 to 481)
  AUTHORS   Huo L and Scarpulla RC.
  TITLE     Multiple 5'-untranslated exons in the nuclear respiratory factor 1
            gene span 47 kb and contribute to transcript heterogeneity and
            translational efficiency
  JOURNAL   Gene 233 (1-2), 213-224 (1999)
   PUBMED   10375638
REFERENCE   10 (residues 1 to 481)
  AUTHORS   Virbasius CA, Virbasius JV and Scarpulla RC.
  TITLE     NRF-1, an activator involved in nuclear-mitochondrial interactions,
            utilizes a new DNA-binding domain conserved in a family of
            developmental regulators
  JOURNAL   Genes Dev 7 (12A), 2431-2445 (1993)
   PUBMED   8253388
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134897.4 and AC153632.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253012.7872344.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 12.47 cM"
     Protein         1..481
                     /product="nuclear respiratory factor 1 isoform j"
                     /note="NRF-1; alpha-pal; alpha palindromic-binding
                     protein"
                     /calculated_mol_wt=51463
     Region          87..283
                     /region_name="Nrf1_DNA-bind"
                     /note="NLS-binding and DNA-binding and dimerization
                     domains of Nrf1; pfam10491"
                     /db_xref="CDD:402218"
     CDS             1..481
                     /gene="Nrf1"
                     /gene_synonym="D6Ertd415e"
                     /coded_by="NM_001410232.1:274..1719"
                     /note="isoform j is encoded by transcript variant 22"
                     /db_xref="GeneID:18181"
                     /db_xref="MGI:MGI:1332235"
ORIGIN      
        1 meehgvtqte hmatieahav aqqvqqvhva tytehsmlsa dedspssped tsyddsdiln
       61 staadevtah laaagpvgma aaaavatgkk rkrphvfesn psirkrqqtr llrklratld
      121 eyttrvgqqa ivlcispskp npvfkvfgaa plenvvrkyk smiledlesa laehapapqe
      181 vnselpplti dgipvsvdkm tqaqlrafip emlkystgrg kpgwgkesck piwwpedipw
      241 anvrsdvrte eqkqrvswtq alrtivkncy kqhgredlly afedqqtqtq attthsiahl
      301 vpsqtvvqtf snpdgtvsli qvgtgatvat ladaselptt vtvaqvnysa vadgeveqnw
      361 atlqggemti qttqaseatq avaslaeaav aasqemqqga tvtmalnsea aahavatlae
      421 atlqgggqiv lsgetaaavg altgvqdang lfmadcggyk wilarrlqaq mefmhgpsak
      481 p
//
LOCUS       NP_001344569             744 aa            linear   ROD 09-OCT-2023
DEFINITION  DNA-binding protein SATB1 isoform 4 [Mus musculus].
ACCESSION   NP_001344569 XP_006523992
VERSION     NP_001344569.1
DBSOURCE    REFSEQ: accession NM_001357640.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 744)
  AUTHORS   Naito T, Ise M, Tanaka Y, Kohwi-Shigematsu T and Kondo M.
  TITLE     Crucial Roles of SATB1 in Regulation of Thymocyte Migration after
            Positive Selection
  JOURNAL   J Immunol 211 (2), 209-218 (2023)
   PUBMED   37256264
  REMARK    GeneRIF: Crucial Roles of SATB1 in Regulation of Thymocyte
            Migration after Positive Selection.
REFERENCE   2  (residues 1 to 744)
  AUTHORS   Nomura A, Kobayashi T, Seo W, Ohno-Oishi M, Kakugawa K, Muroi S,
            Yoshida H, Endo TA, Moro K and Taniuchi I.
  TITLE     Identification of a novel enhancer essential for Satb1 expression
            in TH2 cells and activated ILC2s
  JOURNAL   Life Sci Alliance 6 (8), e202301897 (2023)
   PUBMED   37193606
  REMARK    GeneRIF: Identification of a novel enhancer essential for Satb1
            expression in TH2 cells and activated ILC2s.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 744)
  AUTHORS   Knowles SJ, Stafford AM, Zaman T, Angara K, Williams MR, Newbern JM
            and Vogt D.
  TITLE     Distinct hyperactive RAS/MAPK alleles converge on common GABAergic
            interneuron core programs
  JOURNAL   Development 150 (10) (2023)
   PUBMED   37254876
REFERENCE   4  (residues 1 to 744)
  AUTHORS   Wang B, Ji L and Bian Q.
  TITLE     SATB1 regulates 3D genome architecture in T cells by constraining
            chromatin interactions surrounding CTCF-binding sites
  JOURNAL   Cell Rep 42 (4), 112323 (2023)
   PUBMED   37000624
  REMARK    GeneRIF: SATB1 regulates 3D genome architecture in T cells by
            constraining chromatin interactions surrounding CTCF-binding sites.
REFERENCE   5  (residues 1 to 744)
  AUTHORS   Vasilopoulos N, Kaplanian A, Vinos M, Katsaiti Y, Christodoulou O,
            Denaxa M and Skaliora I.
  TITLE     The role of selective SATB1 deletion in somatostatin expressing
            interneurons on endogenous network activity and the transition to
            epilepsy
  JOURNAL   J Neurosci Res 101 (4), 424-447 (2023)
   PUBMED   36541427
  REMARK    GeneRIF: The role of selective SATB1 deletion in somatostatin
            expressing interneurons on endogenous network activity and the
            transition to epilepsy.
REFERENCE   6  (residues 1 to 744)
  AUTHORS   Seo J, Lozano MM and Dudley JP.
  TITLE     Nuclear matrix binding regulates SATB1-mediated transcriptional
            repression
  JOURNAL   J Biol Chem 280 (26), 24600-24609 (2005)
   PUBMED   15851481
  REMARK    GeneRIF: SATB1-mediated transcriptional repression is regulated by
            nuclear matrix binding
REFERENCE   7  (residues 1 to 744)
  AUTHORS   Nie H, Maika SD, Tucker PW and Gottlieb PD.
  TITLE     A role for SATB1, a nuclear matrix association region-binding
            protein, in the development of CD8SP thymocytes and peripheral T
            lymphocytes
  JOURNAL   J Immunol 174 (8), 4745-4752 (2005)
   PUBMED   15814699
  REMARK    GeneRIF: essential role for SATB1 late in the development and
            maturation of CD8SP T cells
REFERENCE   8  (residues 1 to 744)
  AUTHORS   Cai S, Han HJ and Kohwi-Shigematsu T.
  TITLE     Tissue-specific nuclear architecture and gene expression regulated
            by SATB1
  JOURNAL   Nat Genet 34 (1), 42-51 (2003)
   PUBMED   12692553
  REMARK    GeneRIF: in thymocyte nuclei, SATB1 has a cage-like 'network'
            distribution circumscribing heterochromatin and selectively tethers
            specialized DNA sequences onto its network
REFERENCE   9  (residues 1 to 744)
  AUTHORS   Alvarez JD, Yasui DH, Niida H, Joh T, Loh DY and Kohwi-Shigematsu
            T.
  TITLE     The MAR-binding protein SATB1 orchestrates temporal and spatial
            expression of multiple genes during T-cell development
  JOURNAL   Genes Dev 14 (5), 521-535 (2000)
   PUBMED   10716941
REFERENCE   10 (residues 1 to 744)
  AUTHORS   Nakagomi K, Kohwi Y, Dickinson LA and Kohwi-Shigematsu T.
  TITLE     A novel DNA-binding motif in the nuclear matrix attachment
            DNA-binding protein SATB1
  JOURNAL   Mol Cell Biol 14 (3), 1852-1860 (1994)
   PUBMED   8114718
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154796.2, AC131975.28 and AW045567.1.
            
            On Nov 4, 2017 this sequence version replaced XP_006523992.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660825.95303.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..744
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 26.81 cM"
     Protein         1..744
                     /product="DNA-binding protein SATB1 isoform 4"
                     /note="DNA-binding protein Satb1"
                     /calculated_mol_wt=83309
     Region          72..170
                     /region_name="ULD"
                     /note="Ubiquitin-like oligomerization domain of SATB;
                     pfam16534"
                     /db_xref="CDD:435405"
     Site            order(75,77,94..98,100,132,134,137..138,144..147,155..156,
                     159..161,163..164)
                     /site_type="other"
                     /note="tetramer interface [polypeptide binding]"
                     /db_xref="CDD:211426"
     Region          176..247
                     /region_name="CUTL"
                     /note="CUT1-like DNA-binding domain of SATB; pfam16557"
                     /db_xref="CDD:435427"
     Region          372..444
                     /region_name="CUT"
                     /note="CUT domain; pfam02376"
                     /db_xref="CDD:426745"
     Region          625..682
                     /region_name="HOX"
                     /note="Homeodomain; smart00389"
                     /db_xref="CDD:197696"
     Site            order(627..630,632,650,656,669,671..672,675..676,678..680,
                     682..683)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     Site            order(628,631,672,675..676,679)
                     /site_type="other"
                     /note="specific DNA base contacts [nucleotide binding]"
                     /db_xref="CDD:238039"
     CDS             1..744
                     /gene="Satb1"
                     /gene_synonym="2610306G12Rik"
                     /coded_by="NM_001357640.1:452..2686"
                     /note="isoform 4 is encoded by transcript variant 8"
                     /db_xref="GeneID:20230"
                     /db_xref="MGI:MGI:105084"
ORIGIN      
        1 mdhlneatqg kehsemsnnv sdpkgppaki arleqngspl grgrlgstgg kmqgvplkhs
       61 ghlmktnlrk gtmlpvfcvv ehyenaieyd ckeehaefvl vrkdmlfnql iemallslgy
      121 shssaaqakg liqvgkwnpv plsyvtdapd atvadmlqdv yhvvtlkiql hscpkledlp
      181 peqwshttvr nalkdllkdm nqsslakecp lsqsmissiv nstyyanvsa akcqefgrwy
      241 khfkktkdmm vemdslsels qqganhvnfg qqpvpgntae qppspaqlsh gsqpsvrtpl
      301 pnlhpglvst pispqlvnqq lvmaqllnqq yavnrllaqq slnqqylnhp ppvsrsmnkp
      361 leqqvstnte vsseiyqwvr delkragisq avfarvafnr tqgllseilr keedpktasq
      421 sllvnlramq nflqlpeaer driyqderer slnaasamgp apllstppsr ppqgwlcell
      481 rwkedpspen rtlwenlsmi rrflslpqpe rdaiyeqesn avhhhgdrpp hiihvpaeqi
      541 qslspstlgk gesrgvflps lltpapwpha apqqqqqqqq qqqqqqqppp pppqpqpqpq
      601 agprlpprqp tvassaesde enrqktrprt kisvealgil qsfiqdvgly pdeeaiqtls
      661 aqldlpkyti ikffqnqryy lkhhgklkdn sglevdvaey kdeellkdle esvqdknant
      721 lfsvkleeel svegstdvna dlkd
//
LOCUS       NP_001349242             485 aa            linear   ROD 09-OCT-2023
DEFINITION  CUGBP Elav-like family member 4 isoform 34 [Mus musculus].
ACCESSION   NP_001349242 XP_006525583
VERSION     NP_001349242.1
DBSOURCE    REFSEQ: accession NM_001362313.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 485)
  AUTHORS   Salamon I, Park Y, Miskic T, Kopic J, Matteson P, Page NF, Roque A,
            McAuliffe GW, Favate J, Garcia-Forn M, Shah P, Judas M, Millonig
            JH, Kostovic I, De Rubeis S, Hart RP, Krsnik Z and Rasin MR.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    GeneRIF: Celf4 controls mRNA translation underlying synaptic
            development in the prenatal mammalian neocortex.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 485)
  AUTHORS   Shen Y, Zhang C, Xiao K, Liu D and Xie G.
  TITLE     CELF4 regulates spine formation and depression-like behaviors of
            mice
  JOURNAL   Biochem Biophys Res Commun 605, 39-44 (2022)
   PUBMED   35306363
  REMARK    GeneRIF: CELF4 regulates spine formation and depression-like
            behaviors of mice.
REFERENCE   3  (residues 1 to 485)
  AUTHORS   Moreau MX, Saillour Y, Cwetsch AW, Pierani A and Causeret F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   4  (residues 1 to 485)
  AUTHORS   Li C, Li X, Bi Z, Sugino K, Wang G, Zhu T and Liu Z.
  TITLE     Comprehensive transcriptome analysis of cochlear spiral ganglion
            neurons at multiple ages
  JOURNAL   Elife 9, e50491 (2020)
   PUBMED   31913118
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 485)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 485)
  AUTHORS   Ladd AN, Taffet G, Hartley C, Kearney DL and Cooper TA.
  TITLE     Cardiac tissue-specific repression of CELF activity disrupts
            alternative splicing and causes cardiomyopathy
  JOURNAL   Mol Cell Biol 25 (14), 6267-6278 (2005)
   PUBMED   15988035
  REMARK    GeneRIF: CELF protein activity is required for normal alternative
            splicing in the heart in vivo and normal CELF-mediated alternative
            splicing regulation is in turn required for normal cardiac
            function.
REFERENCE   7  (residues 1 to 485)
  AUTHORS   Meins M, Schlickum S, Wilhelm C, Missbach J, Yadav S, Glaser B,
            Grzmil M, Burfeind P and Laccone F.
  TITLE     Identification and characterization of murine Brunol4, a new member
            of the elav/bruno family
  JOURNAL   Cytogenet Genome Res 97 (3-4), 254-260 (2002)
   PUBMED   12438720
  REMARK    GeneRIF: cloning and characterization
REFERENCE   8  (residues 1 to 485)
  AUTHORS   Ladd AN, Charlet N and Cooper TA.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   9  (residues 1 to 485)
  AUTHORS   Good PJ, Chen Q, Warner SJ and Herring DC.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
REFERENCE   10 (residues 1 to 485)
  AUTHORS   Yulug IG, Egan SE, See CG and Fisher EM.
  TITLE     Mapping GRB2, a signal transduction gene in the human and the mouse
  JOURNAL   Genomics 22 (2), 313-318 (1994)
   PUBMED   7806216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121094.8 and AC144938.3.
            
            On Apr 12, 2018 this sequence version replaced XP_006525583.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.114847.1,
                                           SRR1660817.107084.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 13.92 cM"
     Protein         1..485
                     /product="CUGBP Elav-like family member 4 isoform 34"
                     /note="CUG-BP- and ETR-3-like factor 4; bruno-like protein
                     4; RNA-binding protein BRUNOL-4; bruno-like 4, RNA binding
                     protein"
                     /calculated_mol_wt=51695
     Region          18..39
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          49..135
                     /region_name="RRM1_CELF3_4_5_6"
                     /note="RNA recognition motif 1 (RRM1) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12632"
                     /db_xref="CDD:410041"
     Site            order(55,57,59..60,63,82,84,86,95..97,99,129,131)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410041"
     Region          121..149
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          150..230
                     /region_name="RRM2_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12635"
                     /db_xref="CDD:410043"
     Site            order(152,154,156..157,160,179,181,183,191..193,195,225,
                     227)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410043"
     Region          238..257
                     /region_name="Necessary for TNNT2 exon 5 inclusion.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          416..474
                     /region_name="RRM_SF"
                     /note="RNA recognition motif (RRM) superfamily; cl17169"
                     /db_xref="CDD:450164"
     CDS             1..485
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /coded_by="NM_001362313.1:531..1988"
                     /note="isoform 34 is encoded by transcript variant 38"
                     /db_xref="GeneID:108013"
                     /db_xref="MGI:MGI:1932407"
ORIGIN      
        1 myikmatlan gqadnaslst nglgsspgsa ghmnglshsp gnpstipmkd hdaiklfigq
       61 iprnldekdl kplfeefgki yeltvlkdrf tgmhkgcafl tyceresalk aqsalheqkt
      121 lpgmnrpiqv kpadsesrgg ssclrqppsh rklfvgmlnk qqseddvrrl feafgnieec
      181 tilrgpdgns kgcafvkyss haeaqaaina lhgsqtmpga ssslvvkfad tdkertmrrm
      241 qqmagqmgmf npmaipfgay gayaqalmqq qaalmasvaq ggylnpmaaf aaaqmqqmaa
      301 lnmnglaaap mtptsggstp pgitapavps ipspigvngf tglppqangq paaeavfang
      361 ihpypaqspt aadplqqaya gvqqyagpaa ypaaygqisq afpqpppmip qqqregpegc
      421 nlliyhlpqe fgdaelmqmf lpfgfvsfdn pasaqtaiqa mngfqigmkr lkvqlkrpkd
      481 anrpy
//
LOCUS       NP_001192243             749 aa            linear   ROD 09-OCT-2023
DEFINITION  signal transducer and activator of transcription 1 isoform 2 [Mus
            musculus].
ACCESSION   NP_001192243
VERSION     NP_001192243.1
DBSOURCE    REFSEQ: accession NM_001205314.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 749)
  AUTHORS   Kong P, Yang M, Wang Y, Yu KN, Wu L and Han W.
  TITLE     Ferroptosis triggered by STAT1- IRF1-ACSL4 pathway was involved in
            radiation-induced intestinal injury
  JOURNAL   Redox Biol 66, 102857 (2023)
   PUBMED   37611494
  REMARK    GeneRIF: Ferroptosis triggered by STAT1- IRF1-ACSL4 pathway was
            involved in radiation-induced intestinal injury.
REFERENCE   2  (residues 1 to 749)
  AUTHORS   Clark DN, O'Neil SM, Xu L, Steppe JT, Savage JT, Raghunathan K and
            Filiano AJ.
  TITLE     Prolonged STAT1 activation in neurons drives a pathological
            transcriptional response
  JOURNAL   J Neuroimmunol 382, 578168 (2023)
   PUBMED   37556887
  REMARK    GeneRIF: Prolonged STAT1 activation in neurons drives a
            pathological transcriptional response.
REFERENCE   3  (residues 1 to 749)
  AUTHORS   Imitola J, Hollingsworth EW, Watanabe F, Olah M, Elyaman W,
            Starossom S, Kivisakk P and Khoury SJ.
  TITLE     Stat1 is an inducible transcriptional repressor of neural stem
            cells self-renewal program during neuroinflammation
  JOURNAL   Front Cell Neurosci 17, 1156802 (2023)
   PUBMED   37663126
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 749)
  AUTHORS   Han W, Pu H, Li S, Liu Y, Zhao Y, Xu M, Chen C, Wu Y, Yang T, Ye Q,
            Wang H, Stetler RA, Chen J and Shi Y.
  TITLE     Targeted ablation of signal transducer and activator of
            transduction 1 alleviates inflammation by microglia/macrophages and
            promotes long-term recovery after ischemic stroke
  JOURNAL   J Neuroinflammation 20 (1), 178 (2023)
   PUBMED   37516843
  REMARK    GeneRIF: Targeted ablation of signal transducer and activator of
            transduction 1 alleviates inflammation by microglia/macrophages and
            promotes long-term recovery after ischemic stroke.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 749)
  AUTHORS   Largent AD, Lambert K, Chiang K, Shumlak N, Liggitt D, Oukka M,
            Torgerson TR, Buckner JH, Allenspach EJ, Rawlings DJ and Jackson
            SW.
  TITLE     Dysregulated IFN-gamma signals promote autoimmunity in STAT1
            gain-of-function syndrome
  JOURNAL   Sci Transl Med 15 (703), eade7028 (2023)
   PUBMED   37406138
REFERENCE   6  (residues 1 to 749)
  AUTHORS   Novak U, Harpur AG, Paradiso L, Kanagasundaram V, Jaworowski A,
            Wilks AF and Hamilton JA.
  TITLE     Colony-stimulating factor 1-induced STAT1 and STAT3 activation is
            accompanied by phosphorylation of Tyk2 in macrophages and Tyk2 and
            JAK1 in fibroblasts
  JOURNAL   Blood 86 (8), 2948-2956 (1995)
   PUBMED   7579387
REFERENCE   7  (residues 1 to 749)
  AUTHORS   Finidori J and Kelly PA.
  TITLE     Cytokine receptor signalling through two novel families of
            transducer molecules: Janus kinases, and signal transducers and
            activators of transcription
  JOURNAL   J Endocrinol 147 (1), 11-23 (1995)
   PUBMED   7490523
  REMARK    Review article
REFERENCE   8  (residues 1 to 749)
  AUTHORS   Harroch S, Gothelf Y, Revel M and Chebath J.
  TITLE     5' upstream sequences of MyD88, an IL-6 primary response gene in M1
            cells: detection of functional IRF-1 and Stat factors binding sites
  JOURNAL   Nucleic Acids Res 23 (17), 3539-3546 (1995)
   PUBMED   7567467
REFERENCE   9  (residues 1 to 749)
  AUTHORS   Matsuda T and Hirano T.
  TITLE     Association of p72 tyrosine kinase with Stat factors and its
            activation by interleukin-3, interleukin-6, and granulocyte
            colony-stimulating factor
  JOURNAL   Blood 83 (12), 3457-3461 (1994)
   PUBMED   7515712
REFERENCE   10 (residues 1 to 749)
  AUTHORS   Zhong Z, Wen Z and Darnell JE Jr.
  TITLE     Stat3 and Stat4: members of the family of signal transducers and
            activators of transcription
  JOURNAL   Proc Natl Acad Sci U S A 91 (11), 4806-4810 (1994)
   PUBMED   7545930
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK039458.1, AK084855.1, BC042551.1 and BX513160.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR and uses
            an alternate in-frame splice site in the 3' coding region, compared
            to variant 1. This results in a shorter protein (isoform 2),
            compared to isoform 1. Variants 2, 3, and 4 encode the same
            isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK084855.1, SRR1660813.156759.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..749
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 26.81 cM"
     Protein         1..749
                     /product="signal transducer and activator of transcription
                     1 isoform 2"
                     /calculated_mol_wt=87184
     Region          2..121
                     /region_name="STAT_int"
                     /note="STAT protein, protein interaction domain;
                     smart00964"
                     /db_xref="CDD:214942"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylserine.
                     /evidence=ECO:0000250|UniProtKB:P42224; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     Site            114
                     /site_type="methylation"
                     /note="N6-methyllysine.
                     /evidence=ECO:0000250|UniProtKB:P42224; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     Region          138..313
                     /region_name="STAT1_CCD"
                     /note="Coiled-coil domain of Signal Transducer and
                     Activator of Transcription 1 (STAT1); cd16851"
                     /db_xref="CDD:341076"
     Site            order(164..165,168..169,172,175..176,179,232,236,239..241,
                     243..244,256..257,259..260,263..264,267,271,274,306,
                     309..311)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:341076"
     Site            175
                     /site_type="methylation"
                     /note="N6-methyllysine.
                     /evidence=ECO:0000250|UniProtKB:P42224; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     Site            order(239..241,243..244,256..257,260,263..264,267,271,274,
                     302,306,309..310)
                     /site_type="other"
                     /note="CCD-DBD interface [polypeptide binding]"
                     /db_xref="CDD:341076"
     Site            296
                     /site_type="methylation"
                     /note="N6-methyllysine.
                     /evidence=ECO:0000250|UniProtKB:P42224; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     Region          317..477
                     /region_name="STAT1_DBD"
                     /note="DNA-binding domain of Signal Transducer and
                     Activator of Transcription 1 (STAT1); cd16845"
                     /db_xref="CDD:341083"
     Site            order(336,340,378,411,413,426..427,459..460,463)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:341083"
     Site            366
                     /site_type="methylation"
                     /note="N6-methyllysine.
                     /evidence=ECO:0000250|UniProtKB:P42224; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     Site            525
                     /site_type="methylation"
                     /note="N6-methyllysine.
                     /evidence=ECO:0000250|UniProtKB:P42224; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     Region          557..707
                     /region_name="SH2_STAT1"
                     /note="Src homology 2 (SH2) domain found in signal
                     transducer and activator of transcription (STAT) 1
                     proteins; cd10372"
                     /db_xref="CDD:198235"
     Site            order(584,602,630,632)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198235"
     Site            order(631,647)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198235"
     Site            637
                     /site_type="methylation"
                     /note="N6-methyllysine.
                     /evidence=ECO:0000250|UniProtKB:P42224; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     Site            order(641..642,706)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:198235"
     Site            665
                     /site_type="methylation"
                     /note="N6-methyllysine.
                     /evidence=ECO:0000250|UniProtKB:P42224; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     Site            701
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by JAK1, JAK2 or TYK2.
                     /evidence=ECO:0000269|PubMed:19088846,
                     ECO:0000269|PubMed:22065572; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     Site            708
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by IKKE.
                     /evidence=ECO:0000269|PubMed:17332413,
                     ECO:0000269|PubMed:22065572; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     Region          715..739
                     /region_name="STAT1_TAZ2bind"
                     /note="STAT1 TAZ2 binding domain; pfam12162"
                     /db_xref="CDD:432372"
     Site            724
                     /site_type="other"
                     /note="Required for recruitment of EP300/p300.
                     /evidence=ECO:0000250|UniProtKB:P42224; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     Site            727
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CaMK2 and MAPK14.
                     /evidence=ECO:0000269|PubMed:11972023,
                     ECO:0000269|PubMed:22065572; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     Site            744
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by IKKE.
                     /evidence=ECO:0000305|PubMed:17332413; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     CDS             1..749
                     /gene="Stat1"
                     /gene_synonym="2010005J02Rik"
                     /coded_by="NM_001205314.1:336..2585"
                     /note="isoform 2 is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS56628.1"
                     /db_xref="GeneID:20846"
                     /db_xref="MGI:MGI:103063"
ORIGIN      
        1 msqwfelqql dskfleqvhq lyddsfpmei rqylaqwlek qdwehaaydv sfatirfhdl
       61 lsqlddqysr fslennfllq hnirkskrnl qdnfqedpvq msmiiynclk eerkilenaq
      121 rfnqaqegni qntvmldkqk eldskvrnvk dqvmcieqei ktleelqdey dfkcktsqnr
      181 egeangvaks dqkqeqlllh kmflmldnkr keiihkirel lnsieltqnt lindelvewk
      241 rrqqsacigg ppnacldqlq swftivaetl qqirqqlkkl eeleqkftye pdpitknkqv
      301 lsdrtfllfq qliqssfvve rqpcmpthpq rplvlktgvq ftvklrllvk lqelnynlkv
      361 kvsfdkdvne kntvkgfrkf nilgthtkvm nmeestngsl aaefrhlqlk eqknagnrtn
      421 egplivteel hslsfetqlc qpglvidlet tslpvvvisn vsqlpsgwas ilwynmlvte
      481 prnlsfflnp pcawwsqlse vlswqfssvt krglnadqls mlgekllgpn agpdglipwt
      541 rfckenindk nfsfwpwidt ilelikkhll clwndgcimg fiskereral lkdqqpgtfl
      601 lrfsessreg aitftwvers qnggepdfha vepytkkels avtfpdiirn ykvmaaenip
      661 enplkylypn idkdhafgky ysrpkeapep melddpkrtg yiktelisvs evhpsrlqtt
      721 dnllpmspee fdemsrivgp efdsmmstv
//
LOCUS       NP_001139764             504 aa            linear   ROD 09-OCT-2023
DEFINITION  CUGBP Elav-like family member 4 isoform 22 [Mus musculus].
ACCESSION   NP_001139764
VERSION     NP_001139764.1
DBSOURCE    REFSEQ: accession NM_001146292.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 504)
  AUTHORS   Salamon I, Park Y, Miskic T, Kopic J, Matteson P, Page NF, Roque A,
            McAuliffe GW, Favate J, Garcia-Forn M, Shah P, Judas M, Millonig
            JH, Kostovic I, De Rubeis S, Hart RP, Krsnik Z and Rasin MR.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    GeneRIF: Celf4 controls mRNA translation underlying synaptic
            development in the prenatal mammalian neocortex.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 504)
  AUTHORS   Shen Y, Zhang C, Xiao K, Liu D and Xie G.
  TITLE     CELF4 regulates spine formation and depression-like behaviors of
            mice
  JOURNAL   Biochem Biophys Res Commun 605, 39-44 (2022)
   PUBMED   35306363
  REMARK    GeneRIF: CELF4 regulates spine formation and depression-like
            behaviors of mice.
REFERENCE   3  (residues 1 to 504)
  AUTHORS   Moreau MX, Saillour Y, Cwetsch AW, Pierani A and Causeret F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   4  (residues 1 to 504)
  AUTHORS   Li C, Li X, Bi Z, Sugino K, Wang G, Zhu T and Liu Z.
  TITLE     Comprehensive transcriptome analysis of cochlear spiral ganglion
            neurons at multiple ages
  JOURNAL   Elife 9, e50491 (2020)
   PUBMED   31913118
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 504)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 504)
  AUTHORS   Ladd AN, Taffet G, Hartley C, Kearney DL and Cooper TA.
  TITLE     Cardiac tissue-specific repression of CELF activity disrupts
            alternative splicing and causes cardiomyopathy
  JOURNAL   Mol Cell Biol 25 (14), 6267-6278 (2005)
   PUBMED   15988035
  REMARK    GeneRIF: CELF protein activity is required for normal alternative
            splicing in the heart in vivo and normal CELF-mediated alternative
            splicing regulation is in turn required for normal cardiac
            function.
REFERENCE   7  (residues 1 to 504)
  AUTHORS   Meins M, Schlickum S, Wilhelm C, Missbach J, Yadav S, Glaser B,
            Grzmil M, Burfeind P and Laccone F.
  TITLE     Identification and characterization of murine Brunol4, a new member
            of the elav/bruno family
  JOURNAL   Cytogenet Genome Res 97 (3-4), 254-260 (2002)
   PUBMED   12438720
  REMARK    GeneRIF: cloning and characterization
REFERENCE   8  (residues 1 to 504)
  AUTHORS   Ladd AN, Charlet N and Cooper TA.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   9  (residues 1 to 504)
  AUTHORS   Good PJ, Chen Q, Warner SJ and Herring DC.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
REFERENCE   10 (residues 1 to 504)
  AUTHORS   Yulug IG, Egan SE, See CG and Fisher EM.
  TITLE     Mapping GRB2, a signal transduction gene in the human and the mouse
  JOURNAL   Genomics 22 (2), 313-318 (1994)
   PUBMED   7806216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121094.8, AK048427.1, BC048405.1, AF515450.1, CX242398.1,
            AK038871.1 and AK078071.1.
            
            Transcript Variant: This variant (1) encodes isoform (22, also
            known as A).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC048405.1, SRR1660817.289057.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 13.92 cM"
     Protein         1..504
                     /product="CUGBP Elav-like family member 4 isoform 22"
                     /note="CUG-BP- and ETR-3-like factor 4; bruno-like protein
                     4; RNA-binding protein BRUNOL-4; bruno-like 4, RNA binding
                     protein"
                     /calculated_mol_wt=53807
     Region          49..135
                     /region_name="RRM1_CELF3_4_5_6"
                     /note="RNA recognition motif 1 (RRM1) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12632"
                     /db_xref="CDD:410041"
     Site            order(55,57,59..60,63,82,84,86,95..97,99,129,131)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410041"
     Region          150..230
                     /region_name="RRM2_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12635"
                     /db_xref="CDD:410043"
     Site            order(152,154,156..157,160,179,181,183,191..193,195,225,
                     227)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410043"
     Region          415..493
                     /region_name="RRM3_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12639"
                     /db_xref="CDD:241083"
     CDS             1..504
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /coded_by="NM_001146292.2:531..2045"
                     /note="isoform 22 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS50241.1"
                     /db_xref="GeneID:108013"
                     /db_xref="MGI:MGI:1932407"
ORIGIN      
        1 myikmatlan gqadnaslst nglgsspgsa ghmnglshsp gnpstipmkd hdaiklfigq
       61 iprnldekdl kplfeefgki yeltvlkdrf tgmhkgcafl tyceresalk aqsalheqkt
      121 lpgmnrpiqv kpadsesrgg ssclrqppsh rklfvgmlnk qqseddvrrl feafgnieec
      181 tilrgpdgns kgcafvkyss haeaqaaina lhgsqtmpga ssslvvkfad tdkertmrrm
      241 qqmagqmgmf npmaipfgay gayaqalmqq qaalmasvaq ggylnpmaaf aaaqmqqmaa
      301 lnmnglaaap mtptsggstp pgitapavps ipspigvngf tglppqangq paaeavfang
      361 ihpypaqspt aadplqqaya gvqqyagpay paaygqisqa fpqpppmipq qqregpegcn
      421 lliyhlpqef gdaelmqmfl pfgnvisskv fvdratnqsk cfgfvsfdnp asaqtaiqam
      481 ngfqigmkrl kvqlkrpkda nrpy
//
LOCUS       NP_001263339            2296 aa            linear   ROD 09-OCT-2023
DEFINITION  fibronectin isoform d precursor [Mus musculus].
ACCESSION   NP_001263339
VERSION     NP_001263339.1
DBSOURCE    REFSEQ: accession NM_001276410.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 2296)
  AUTHORS   Huo X, Ma S, Wang C, Song L, Yao B, Zhu S, Li P, Wang L, Wu Z and
            Wang K.
  TITLE     Unravelling the role of immune cells and FN1 in the recurrence and
            therapeutic process of skull base chordoma
  JOURNAL   Clin Transl Med 13 (10), e1429 (2023)
   PUBMED   37784253
  REMARK    GeneRIF: Unravelling the role of immune cells and FN1 in the
            recurrence and therapeutic process of skull base chordoma.
REFERENCE   2  (residues 1 to 2296)
  AUTHORS   Whisler J, Shahreza S, Schlegelmilch K, Ege N, Javanmardi Y,
            Malandrino A, Agrawal A, Fantin A, Serwinski B, Azizgolshani H,
            Park C, Shone V, Demuren OO, Del Rosario A, Butty VL, Holroyd N,
            Domart MC, Hooper S, Szita N, Boyer LA, Walker-Samuel S, Djordjevic
            B, Sheridan GK, Collinson L, Calvo F, Ruhrberg C, Sahai E, Kamm R
            and Moeendarbary E.
  TITLE     Emergent mechanical control of vascular morphogenesis
  JOURNAL   Sci Adv 9 (32), eadg9781 (2023)
   PUBMED   37566656
REFERENCE   3  (residues 1 to 2296)
  AUTHORS   Jena SK, Das S, Chakraborty S and Ain R.
  TITLE     Molecular determinants of epithelial mesenchymal transition in
            mouse placenta and trophoblast stem cell
  JOURNAL   Sci Rep 13 (1), 10978 (2023)
   PUBMED   37414855
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 2296)
  AUTHORS   Hiver S, Shimizu-Mizuno N, Ikawa Y, Kajikawa E, Sai X, Nishimura H,
            Takaoka K, Nishimura O, Kuraku S, Tanaka S and Hamada H.
  TITLE     Gse1, a component of the CoREST complex, is required for placenta
            development in the mouse
  JOURNAL   Dev Biol 498, 97-105 (2023)
   PUBMED   37019373
REFERENCE   5  (residues 1 to 2296)
  AUTHORS   Ozguldez HO, Govindasamy N, Fan R, Long H, Mildner K, Zeuschner D,
            Trappmann B, Ranga A and Bedzhov I.
  TITLE     Polarity inversion reorganizes the stem cell compartment of the
            trophoblast lineage
  JOURNAL   Cell Rep 42 (4), 112313 (2023)
   PUBMED   36989113
REFERENCE   6  (residues 1 to 2296)
  AUTHORS   Saga Y, Yagi T, Ikawa Y, Sakakura T and Aizawa S.
  TITLE     Mice develop normally without tenascin
  JOURNAL   Genes Dev 6 (10), 1821-1831 (1992)
   PUBMED   1383086
REFERENCE   7  (residues 1 to 2296)
  AUTHORS   Khandjian EW, Salomon C, Leonard N, Tremblay S and Turler H.
  TITLE     Fibronectin gene expression in proliferating, quiescent, and
            SV40-infected mouse kidney cells
  JOURNAL   Exp Cell Res 202 (2), 464-470 (1992)
   PUBMED   1327855
REFERENCE   8  (residues 1 to 2296)
  AUTHORS   Vidal SM, Epstein DJ, Malo D, Weith A, Vekemans M and Gros P.
  TITLE     Identification and mapping of six microdissected genomic DNA probes
            to the proximal region of mouse chromosome 1
  JOURNAL   Genomics 14 (1), 32-37 (1992)
   PUBMED   1358796
REFERENCE   9  (residues 1 to 2296)
  AUTHORS   Malo D, Schurr E, Epstein DJ, Vekemans M, Skamene E and Gros P.
  TITLE     The host resistance locus Bcg is tightly linked to a group of
            cytoskeleton-associated protein genes that include villin and
            desmin
  JOURNAL   Genomics 10 (2), 356-364 (1991)
   PUBMED   1676979
REFERENCE   10 (residues 1 to 2296)
  AUTHORS   Wartiovaara,J., Leivo,I. and Vaheri,A.
  TITLE     Expression of the cell surface-associated glycoprotein,
            fibronectin, in the early mouse embryo
  JOURNAL   Dev Biol 69 (1), 247-257 (1979)
   PUBMED   376373
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ098561.1, AK171339.1, CK639246.1, CN692112.1, CN536551.1,
            CN532664.1, AK147315.1 and AC124821.5.
            
            Transcript Variant: This variant (4) lacks two in-frame exons in
            the coding region, compared to variant 1. The encoded isoform (d)
            is shorter than isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK170755.1, SRR10223971.453.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2296
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 36.05 cM"
     Protein         1..2296
                     /product="fibronectin isoform d precursor"
                     /calculated_mol_wt=250233
     sig_peptide     1..27
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=2797
     Region          53..90
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain, approximately 40 residue
                     long with two conserved disulfide bridges. FN1 is one of
                     three types of internal repeats which combine to form
                     larger domains within fibronectin. Fibronectin, a plasma
                     protein that binds cell surfaces...; cd00061"
                     /db_xref="CDD:238018"
     Region          98..141
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          142..185
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          187..231
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          232..271
                     /region_name="fn1"
                     /note="Fibronectin type I domain; pfam00039"
                     /db_xref="CDD:425437"
     Region          308..347
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          353..401
                     /region_name="FN2"
                     /note="Fibronectin type 2 domain; smart00059"
                     /db_xref="CDD:128373"
     Site            order(364,366,371,385,392,398,400)
                     /site_type="active"
                     /note="putative gelatin-binding site [active]"
                     /db_xref="CDD:238019"
     Region          413..461
                     /region_name="FN2"
                     /note="Fibronectin type 2 domain; smart00059"
                     /db_xref="CDD:128373"
     Site            order(424,426,431,445,452,458,460)
                     /site_type="active"
                     /note="putative gelatin-binding site [active]"
                     /db_xref="CDD:238019"
     Region          470..513
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          518..560
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          561..604
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          619..688
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Region          726..797
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(797..798,800..801)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Site            order(810,871,886)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Region          811..882
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(887..888,890..891)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          907..987
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(984..985,987..988)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          997..1075
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(1073..1074,1076..1077)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1091..1158
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Region          1174..1257
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(1254..1255,1257..1258)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1267..1348
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Region          1358..1438
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Region          1450..1529
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(1525..1526,1528..1529)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1542..1622
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(1619..1620,1622..1623)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1632..1712
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(1709..1710,1712..1713)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1724..1803
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(1800..1801,1803..1804)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1813..1893
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Region          2029..2084
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Region          2115..2159
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          2160..2201
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          2203..2242
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain, approximately 40 residue
                     long with two conserved disulfide bridges. FN1 is one of
                     three types of internal repeats which combine to form
                     larger domains within fibronectin. Fibronectin, a plasma
                     protein that binds cell surfaces...; cd00061"
                     /db_xref="CDD:238018"
     CDS             1..2296
                     /gene="Fn1"
                     /gene_synonym="E330027I09; Fn; Fn-1"
                     /coded_by="NM_001276410.1:253..7143"
                     /note="isoform d precursor is encoded by transcript
                     variant 4"
                     /db_xref="CCDS:CCDS78609.1"
                     /db_xref="GeneID:14268"
                     /db_xref="MGI:MGI:95566"
ORIGIN      
        1 mlrgpgpgrl lllavlclgt svrcteagks krqaqqivqp qspvavsqsk pgcfdngkhy
       61 qinqqwerty lgnalvctcy ggsrgfnces kpepeetcfd kytgntykvg dtyerpkdsm
      121 iwdctcigag rgrisctian rcheggqsyk igdkwrrphe tggymleclc lgngkgewtc
      181 kpiaekcfdh aagtsyvvge twekpyqgwm mvdctclgeg ngritctsrn rcndqdtrts
      241 yrigdtwskk dnrgnllqcv ctgngrgewk cerhalqsas agsgsftdvr taiyqpqthp
      301 qpapyghcvt dsgvvysvgm qwlksqgnkq mlctclgngv scqetavtqt yggnsngepc
      361 vlpftyngrt fyscttegrq dghlwcstts nyeqdqkysf ctdhavlvqt rggnsngalc
      421 hfpflynnrn ytdctsegrr dnmkwcgttq nydadqkfgf cpmaaheeic ttnegvmyri
      481 gdqwdkqhdl ghmmrctcvg ngrgewacip ysqlrdqciv dditynvndt fhkrheeghm
      541 lnctcfgqgr grwkcdpidq cqdsetrtfy qigdswekfv hgvryqcycy grgigewhcq
      601 plqtypgttg pvqviitetp sqpnshpiqw napepshitk yilrwrpkts tgrwkeatip
      661 ghlnsytikg ltpgviyegq lisiqqyghr evtrfdftts astpvtsntv tgetapyspv
      721 vatsesvtei tassfvvswv sasdtvsgfr veyelseegd epqyldlpst atsvnipdll
      781 pgrkyivnvy qiseegkqsl ilstsqttap dappdptvdq vddtsivvrw srpqapitgy
      841 rivyspsveg sstelnlpet ansvtlsdlq pgvqynitiy aveenqestp vfiqqettgt
      901 prsdnvpppt dlqfveltdv kvtimwtppd svvsgyrvev lpvslpgehg qrlpvnrntf
      961 aeitglspgv tylfkvfavh qgresnplta qqttkldapt nlqfvnetdr tvlvtwtppr
     1021 ariagyrlta gltrggqpkq ynvgplasky plrnlqpgse ytvtlvavkg nqqspkatgv
     1081 fttlqplrsi ppyntevtet tivitwtpap rigfklgvrp sqggeaprev tsdsgsivvs
     1141 gltpgveyty tiqvlrdgqe rdapivnrvv tplspptnlh leanpdtgvl tvswersttp
     1201 ditgyrittt ptngqqgtsl eevvhadqss ctfenlnpgl eynvsvytvk ddkesapisd
     1261 tvvpavpppt dlrftnigpd tmrvtwappp sieltnllvr yspvkneedv aelsispsdn
     1321 avvltnllpg teylvsvssv yeqhesiplr grqktgldsp tgfdssdita nsftvhwvap
     1381 rapitgyiir hhaehsvgrp rqdrvppsrn sitltnlnpg teyvvsiiav ngreesppli
     1441 gqqatvsdip rdleviastp tslliswepp avsvryyrit ygetggnspv qeftvpgsks
     1501 tatinnikpg adytitlyav tgrgdspass kpvsinykte idkpsqmqvt dvqdnsisvr
     1561 wlpstspvtg yrvtttpkng lgpsktktas pdqtemtieg lqptveyvvs vyaqnrnges
     1621 qplvqtavtt ipaptnlkfs qvtptsftaq wiapsvqltg yrvrvnpkek tgpmkeinls
     1681 pdsssvivsg lmvatkyevs vyalkdtlts rpaqgvittl envspprrar vtdatettit
     1741 iswrtkteti tgfqvdaipa ngqtpvqrsi spdvrsytit glqpgtdyki hlytlndnar
     1801 sspviidast aidapsnlrf ltttpnsllv swqaprarit gyiikyekpg spprevvprp
     1861 rpgvteatit glepgteyti yvialknnqk sepligrkkt delpqlvtlp hpnlhgpeil
     1921 dvpstvqktp fitnpgydte ngiqlpgtth qqpsvgqqmi feehgfrrtt pptaatpvrl
     1981 rprpylpnvd eevqighvpr gdvdyhlyph vpglnpnast gqealsqtti swtpfqesse
     2041 yiiscqpvgt deeplqfqvp gtstsatltg ltrgvtynii vealqnqrrh kvreevvtvg
     2101 navseglnqp tddscfdpyt vshyaigeew erlsdagfkl tcqclgfgsg hfrcdsskwc
     2161 hdngvnykig ekwdrqgeng qrmsctclgn gkgefkcdph eatcyddgkt yhvgeqwqke
     2221 ylgaicsctc fggqrgwrcd ncrrpgaaep spdgttghty nqytqrynqr tntnvncpie
     2281 cfmpldvqad rddsre
//
LOCUS       NP_031603                351 aa            linear   ROD 09-OCT-2023
DEFINITION  C5a anaphylatoxin chemotactic receptor 1 [Mus musculus].
ACCESSION   NP_031603
VERSION     NP_031603.2
DBSOURCE    REFSEQ: accession NM_007577.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 351)
  AUTHORS   Petrisko TJ, Gargus M, Chu SH, Selvan P, Whiteson KL and Tenner AJ.
  TITLE     Influence of complement protein C1q or complement receptor C5aR1 on
            gut microbiota composition in wildtype and Alzheimer's mouse models
  JOURNAL   J Neuroinflammation 20 (1), 211 (2023)
   PUBMED   37726739
  REMARK    GeneRIF: Influence of complement protein C1q or complement receptor
            C5aR1 on gut microbiota composition in wildtype and Alzheimer's
            mouse models.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 351)
  AUTHORS   Wiese AV, Duhn J, Korkmaz RU, Quell KM, Osman I, Ender F, Schroder
            T, Lewkowich I, Hogan S, Huber-Lang M, Gumprecht F, Konig P, Kohl J
            and Laumonnier Y.
  TITLE     C5aR1 activation in mice controls inflammatory eosinophil
            recruitment and functions in allergic asthma
  JOURNAL   Allergy 78 (7), 1893-1908 (2023)
   PUBMED   36757006
  REMARK    GeneRIF: C5aR1 activation in mice controls inflammatory eosinophil
            recruitment and functions in allergic asthma.
REFERENCE   3  (residues 1 to 351)
  AUTHORS   Silva BM, Gomes GF, Veras FP, Cambier S, Silva GV, Quadros AU,
            Caetite DB, Nascimento DC, Silva CM, Silva JC, Damasceno S,
            Schneider AH, Beretta F, Batah SS, Castro IM, Paiva IM, Rodrigues
            T, Salina A, Martins R, Cebinelli GC, Bibo NL, Jorge DM, Nakaya HI,
            Zamboni DS, Leiria LO, Fabro AT, Alves-Filho JC, Arruda E,
            Louzada-Junior P, Oliveira RD, Cunha LD, Van Mol P, Vanderbeke L,
            Feys S, Wauters E, Brandolini L, Aramini A, Cunha FQ, Kohl J,
            Allegretti M, Lambrechts D, Wauters J, Proost P and Cunha TM.
  TITLE     C5aR1 signaling triggers lung immunopathology in COVID-19 through
            neutrophil extracellular traps
  JOURNAL   J Clin Invest 133 (12), e163105 (2023)
   PUBMED   37104043
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 351)
  AUTHORS   Ratajczak MZ, Adamiak M, Abdelbaset-Ismail A, Bujko K, Thapa A,
            Chumak V, Franczak S, Brzezniakiewicz-Janus K, Ratajczak J and
            Kucia M.
  TITLE     Intracellular complement (complosome) is expressed in hematopoietic
            stem/progenitor cells (HSPCs) and regulates cell trafficking,
            metabolism and proliferation in an intracrine Nlrp3
            inflammasome-dependent manner
  JOURNAL   Leukemia 37 (6), 1401-1405 (2023)
   PUBMED   37055506
REFERENCE   5  (residues 1 to 351)
  AUTHORS   Kong LR, Chen XH, Sun Q, Zhang KY, Xu L, Ding L, Zhou YP, Zhang ZB,
            Lin JR and Gao PJ.
  TITLE     Loss of C3a and C5a receptors promotes adipocyte browning and
            attenuates diet-induced obesity via activating inosine/A2aR pathway
  JOURNAL   Cell Rep 42 (2), 112078 (2023)
   PUBMED   36735535
  REMARK    GeneRIF: Loss of C3a and C5a receptors promotes adipocyte browning
            and attenuates diet-induced obesity via activating inosine/A2aR
            pathway.
REFERENCE   6  (residues 1 to 351)
  AUTHORS   Clynes R, Maizes JS, Guinamard R, Ono M, Takai T and Ravetch JV.
  TITLE     Modulation of immune complex-induced inflammation in vivo by the
            coordinate expression of activation and inhibitory Fc receptors
  JOURNAL   J Exp Med 189 (1), 179-185 (1999)
   PUBMED   9874574
REFERENCE   7  (residues 1 to 351)
  AUTHORS   Hopken UE, Lu B, Gerard NP and Gerard C.
  TITLE     Impaired inflammatory responses in the reverse arthus reaction
            through genetic deletion of the C5a receptor
  JOURNAL   J Exp Med 186 (5), 749-756 (1997)
   PUBMED   9271590
REFERENCE   8  (residues 1 to 351)
  AUTHORS   Bozic CR, Lu B, Hopken UE, Gerard C and Gerard NP.
  TITLE     Neurogenic amplification of immune complex inflammation
  JOURNAL   Science 273 (5282), 1722-1725 (1996)
   PUBMED   8781237
REFERENCE   9  (residues 1 to 351)
  AUTHORS   Hopken UE, Lu B, Gerard NP and Gerard C.
  TITLE     The C5a chemoattractant receptor mediates mucosal defence to
            infection
  JOURNAL   Nature 383 (6595), 86-89 (1996)
   PUBMED   8779720
REFERENCE   10 (residues 1 to 351)
  AUTHORS   Gerard C, Bao L, Orozco O, Pearson M, Kunz D and Gerard NP.
  TITLE     Structural diversity in the extracellular faces of peptidergic
            G-protein-coupled receptors. Molecular cloning of the mouse C5a
            anaphylatoxin receptor
  JOURNAL   J Immunol 149 (8), 2600-2606 (1992)
   PUBMED   1401897
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB666123.1, BC125641.1 and AC156630.6.
            
            On Feb 15, 2005 this sequence version replaced NP_031603.1.
            
            Transcript Variant: This variant (1) and variant 2 encode the same
            protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BB666123.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849374,
                                           SAMN00849375 [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..351
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 8.77 cM"
     Protein         1..351
                     /product="C5a anaphylatoxin chemotactic receptor 1"
                     /note="C5a anaphylatoxin receptor; C5a-R; complement
                     component 5, receptor 1; C5a ligand"
                     /calculated_mol_wt=38892
     Site            6
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P30993.2)"
     Site            13
                     /site_type="sulfatation"
                     /note="Sulfotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P21730; propagated from
                     UniProtKB/Swiss-Prot (P30993.2)"
     Site            16
                     /site_type="sulfatation"
                     /note="Sulfotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P21730; propagated from
                     UniProtKB/Swiss-Prot (P30993.2)"
     Region          38..312
                     /region_name="7tm_GPCRs"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; cl28897"
                     /db_xref="CDD:452889"
     Site            38..64
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P30993.2)"
     Region          40..64
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:410628"
     Site            70..93
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P30993.2)"
     Region          72..93
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:410628"
     Region          110..132
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:410628"
     Site            111..132
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P30993.2)"
     Site            154..174
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P30993.2)"
     Region          155..171
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:410628"
     Region          201..224
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:410628"
     Site            202..227
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P30993.2)"
     Region          242..264
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:410628"
     Site            244..266
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P30993.2)"
     Region          280..305
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:410628"
     Site            284..304
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P30993.2)"
     Site            315
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P21730; propagated from
                     UniProtKB/Swiss-Prot (P30993.2)"
     Site            318
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P21730; propagated from
                     UniProtKB/Swiss-Prot (P30993.2)"
     Site            325
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19144319,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P30993.2)"
     Site            328
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P21730; propagated from
                     UniProtKB/Swiss-Prot (P30993.2)"
     Region          329..351
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P30993.2)"
     Site            333
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19144319; propagated from
                     UniProtKB/Swiss-Prot (P30993.2)"
     Site            339
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P21730; propagated from
                     UniProtKB/Swiss-Prot (P30993.2)"
     CDS             1..351
                     /gene="C5ar1"
                     /gene_synonym="C5aR; C5r1; Cd88; D7Msu1"
                     /coded_by="NM_007577.4:131..1186"
                     /db_xref="CCDS:CCDS20846.1"
                     /db_xref="GeneID:12273"
                     /db_xref="MGI:MGI:88232"
ORIGIN      
        1 mdpidnssfe inydhygtmd pnipadgihl pkrqpgdvaa liiysvvflv gvpgnalvvw
       61 vtafearrav naiwflnlav adllsclalp vlfttvlnhn ywyfdataci vlpslillnm
      121 yasilllati sadrfllvfk piwcqkvrgt glawmacgva wvlallltip sfvyreaykd
      181 fysehtvcgi nygggsfpke kavailrlmv gfvlplltln icytflllrt wsrkatrstk
      241 tlkvvmavvi cffifwlpyq vtgvmiawlp pssptlkrve klnslcvsla yinccvnpii
      301 yvmagqgfhg rllrslpsii rnalsedsvg rdsktftpst tdtstrksqa v
//
LOCUS       NP_001349264             447 aa            linear   ROD 09-OCT-2023
DEFINITION  CUGBP Elav-like family member 4 isoform 53 [Mus musculus].
ACCESSION   NP_001349264 XP_017173289
VERSION     NP_001349264.1
DBSOURCE    REFSEQ: accession NM_001362335.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 447)
  AUTHORS   Salamon I, Park Y, Miskic T, Kopic J, Matteson P, Page NF, Roque A,
            McAuliffe GW, Favate J, Garcia-Forn M, Shah P, Judas M, Millonig
            JH, Kostovic I, De Rubeis S, Hart RP, Krsnik Z and Rasin MR.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    GeneRIF: Celf4 controls mRNA translation underlying synaptic
            development in the prenatal mammalian neocortex.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 447)
  AUTHORS   Shen Y, Zhang C, Xiao K, Liu D and Xie G.
  TITLE     CELF4 regulates spine formation and depression-like behaviors of
            mice
  JOURNAL   Biochem Biophys Res Commun 605, 39-44 (2022)
   PUBMED   35306363
  REMARK    GeneRIF: CELF4 regulates spine formation and depression-like
            behaviors of mice.
REFERENCE   3  (residues 1 to 447)
  AUTHORS   Moreau MX, Saillour Y, Cwetsch AW, Pierani A and Causeret F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   4  (residues 1 to 447)
  AUTHORS   Li C, Li X, Bi Z, Sugino K, Wang G, Zhu T and Liu Z.
  TITLE     Comprehensive transcriptome analysis of cochlear spiral ganglion
            neurons at multiple ages
  JOURNAL   Elife 9, e50491 (2020)
   PUBMED   31913118
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 447)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 447)
  AUTHORS   Ladd AN, Taffet G, Hartley C, Kearney DL and Cooper TA.
  TITLE     Cardiac tissue-specific repression of CELF activity disrupts
            alternative splicing and causes cardiomyopathy
  JOURNAL   Mol Cell Biol 25 (14), 6267-6278 (2005)
   PUBMED   15988035
  REMARK    GeneRIF: CELF protein activity is required for normal alternative
            splicing in the heart in vivo and normal CELF-mediated alternative
            splicing regulation is in turn required for normal cardiac
            function.
REFERENCE   7  (residues 1 to 447)
  AUTHORS   Meins M, Schlickum S, Wilhelm C, Missbach J, Yadav S, Glaser B,
            Grzmil M, Burfeind P and Laccone F.
  TITLE     Identification and characterization of murine Brunol4, a new member
            of the elav/bruno family
  JOURNAL   Cytogenet Genome Res 97 (3-4), 254-260 (2002)
   PUBMED   12438720
  REMARK    GeneRIF: cloning and characterization
REFERENCE   8  (residues 1 to 447)
  AUTHORS   Ladd AN, Charlet N and Cooper TA.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   9  (residues 1 to 447)
  AUTHORS   Good PJ, Chen Q, Warner SJ and Herring DC.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
REFERENCE   10 (residues 1 to 447)
  AUTHORS   Yulug IG, Egan SE, See CG and Fisher EM.
  TITLE     Mapping GRB2, a signal transduction gene in the human and the mouse
  JOURNAL   Genomics 22 (2), 313-318 (1994)
   PUBMED   7806216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121094.8 and AC144938.3.
            
            On Apr 12, 2018 this sequence version replaced XP_017173289.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.159897.1,
                                           SRR10662772.1815682.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..447
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 13.92 cM"
     Protein         1..447
                     /product="CUGBP Elav-like family member 4 isoform 53"
                     /note="CUG-BP- and ETR-3-like factor 4; bruno-like protein
                     4; RNA-binding protein BRUNOL-4; bruno-like 4, RNA binding
                     protein"
                     /calculated_mol_wt=47525
     Region          49..135
                     /region_name="RRM1_CELF3_4_5_6"
                     /note="RNA recognition motif 1 (RRM1) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12632"
                     /db_xref="CDD:410041"
     Site            order(55,57,59..60,63,82,84,86,95..97,99,129,131)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410041"
     Region          56..443
                     /region_name="ELAV_HUD_SF"
                     /note="ELAV/HuD family splicing factor; TIGR01661"
                     /db_xref="CDD:273741"
     Region          141..221
                     /region_name="RRM2_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12635"
                     /db_xref="CDD:410043"
     Site            order(143,145,147..148,151,170,172,174,182..184,186,216,
                     218)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410043"
     CDS             1..447
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /coded_by="NM_001362335.1:531..1874"
                     /note="isoform 53 is encoded by transcript variant 54"
                     /db_xref="GeneID:108013"
                     /db_xref="MGI:MGI:1932407"
ORIGIN      
        1 myikmatlan gqadnaslst nglgsspgsa ghmnglshsp gnpstipmkd hdaiklfigq
       61 iprnldekdl kplfeefgki yeltvlkdrf tgmhkgcafl tyceresalk aqsalheqkt
      121 lpgmnrpiqv kpadsesrge drklfvgmln kqqseddvrr lfeafgniee ctilrgpdgn
      181 skgcafvkys shaeaqaain alhgsqtmpg assslvvkfa dtdkertmrr mqqmagqmgm
      241 fnpmaipfga ygayaqalmq qqaalmasva qggylnpmaa faaaqmqqma alnmnglaaa
      301 pmtptsggst ppgitapavp sipspigvng ftglppqang qpaaeavfan gihpypaqsp
      361 taadplqqay agvqqyagpa ypaaygqisq afpqpppmip qqqregfvsf dnpasaqtai
      421 qamngfqigm krlkvqlkrp kdanrpy
//
LOCUS       NP_001074944             448 aa            linear   ROD 09-OCT-2023
DEFINITION  nuclear autoantigenic sperm protein isoform 1 [Mus musculus].
ACCESSION   NP_001074944
VERSION     NP_001074944.1
DBSOURCE    REFSEQ: accession NM_001081475.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 448)
  AUTHORS   Bao Y, Lian M, Chen Y, Gu X, Cao K, Du X and Ju J.
  TITLE     sNASP Mutation Aggravates to the TLR4-Mediated Inflammation in SLE
            by TAK1 Pathway
  JOURNAL   J Immunol Res 2023, 4877700 (2023)
   PUBMED   37771504
  REMARK    GeneRIF: sNASP Mutation Aggravates to the TLR4-Mediated
            Inflammation in SLE by TAK1 Pathway.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 448)
  AUTHORS   Li J, Jiang H, Mu Y, Wei Z, Ma A, Sun M, Zhao J, Zhu C and Chen X.
  TITLE     SRSF10 regulates proliferation of neural progenitor cells and
            affects neurogenesis in developing mouse neocortex
  JOURNAL   iScience 26 (7), 107042 (2023)
   PUBMED   37360696
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 448)
  AUTHORS   Zhang Y, Yan H, Zhu J, Chen L, Wang H and Ju J.
  TITLE     [Hepatic fibrosis aggravation in nuclear autoantigenic sperm
            protein (NASP) mutant mice induced by concanavalin A]
  JOURNAL   Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 38 (7), 577-583 (2022)
   PUBMED   35786450
  REMARK    GeneRIF: [Hepatic fibrosis aggravation in nuclear autoantigenic
            sperm protein (NASP) mutant mice induced by concanavalin A].
REFERENCE   4  (residues 1 to 448)
  AUTHORS   Zhang J, Du X, Wang H, Bao Y, Lian M, Xu Z and Ju J.
  TITLE     A Variant of sNASP Exacerbates Lymphocyte Subset Disorder and
            Nephritis in a Spontaneous Lupus Model Sle1.Yaa Mouse
  JOURNAL   Mediators Inflamm 2021, 8175863 (2021)
   PUBMED   34720750
  REMARK    GeneRIF: A Variant of sNASP Exacerbates Lymphocyte Subset Disorder
            and Nephritis in a Spontaneous Lupus Model Sle1.Yaa Mouse.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 448)
  AUTHORS   Ju J, Xu J, Zhu Y, Fu X, Morel L and Xu Z.
  TITLE     A Variant of the Histone-Binding Protein sNASP Contributes to Mouse
            Lupus
  JOURNAL   Front Immunol 10, 637 (2019)
   PUBMED   31001259
  REMARK    GeneRIF: A Variant of the Histone-Binding Protein sNASP Contributes
            to Mouse Lupus.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 448)
  AUTHORS   Piao Y, Ko NT, Lim MK and Ko MS.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   7  (residues 1 to 448)
  AUTHORS   Richardson RT, Bencic DC and O'Rand MG.
  TITLE     Comparison of mouse and human NASP genes and expression in human
            transformed and tumor cell lines
  JOURNAL   Gene 274 (1-2), 67-75 (2001)
   PUBMED   11674998
REFERENCE   8  (residues 1 to 448)
  AUTHORS   Richardson RT, Batova IN, Widgren EE, Zheng LX, Whitfield M,
            Marzluff WF and O'Rand MG.
  TITLE     Characterization of the histone H1-binding protein, NASP, as a cell
            cycle-regulated somatic protein
  JOURNAL   J Biol Chem 275 (39), 30378-30386 (2000)
   PUBMED   10893414
REFERENCE   9  (residues 1 to 448)
  AUTHORS   Hemberger M, Himmelbauer H, Ruschmann J, Zeitz C and Fundele R.
  TITLE     cDNA subtraction cloning reveals novel genes whose temporal and
            spatial expression indicates association with trophoblast invasion
  JOURNAL   Dev Biol 222 (1), 158-169 (2000)
   PUBMED   10885754
REFERENCE   10 (residues 1 to 448)
  AUTHORS   Leimeister C, Bach A, Woolf AS and Gessler M.
  TITLE     Screen for genes regulated during early kidney morphogenesis
  JOURNAL   Dev Genet 24 (3-4), 273-283 (1999)
   PUBMED   10322635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK083333.1 and AL669953.7.
            
            Transcript Variant: This variant (1) differs in the 5' UTR and
            lacks an alternate in-frame exon in the coding region, compared to
            variant 2. It encodes isoform 1, which is shorter than isoform 2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK083333.1, SRR1660815.131659.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..448
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 53.24 cM"
     Protein         1..448
                     /product="nuclear autoantigenic sperm protein isoform 1"
                     /note="somatic histone binding protein NASP"
                     /calculated_mol_wt=48635
     Region          172..195
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          201..277
                     /region_name="TPR_12"
                     /note="Tetratricopeptide repeat; pfam13424"
                     /db_xref="CDD:315987"
     Region          203..240
                     /region_name="SHNi-TPR"
                     /note="pfam10516"
                     /db_xref="CDD:402238"
     Region          203..231
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(204,207..208,211..212,214,246,249..250,253..254,
                     256..257,278,281..282,285)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          236..274
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..448
                     /gene="Nasp"
                     /gene_synonym="5033430J04Rik; D4Ertd767e; Epcs32; Nasp-T"
                     /coded_by="NM_001081475.1:108..1454"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS38852.1"
                     /db_xref="GeneID:50927"
                     /db_xref="MGI:MGI:1355328"
ORIGIN      
        1 matestaaaa iaaelvsadk iedapapsts adkmesldvd seakkllglg qkhlvmgdip
       61 aavnafqeaa sllgkkyget anecgeafff ygksllelar mengvlgnal egvhveeeeg
      121 ektedeslve nndnvdeteg seeedrendk aeetpnesvl ekkslqenee eeignlelaw
      181 dmldlakiif krqetkeaql yaaqahlklg evsvesenyi qaveefqacl slqeqyleah
      241 drllaethyq lglaygynsq ydeavaqfgk sidviekrma vlheqmkeae gsfteyekei
      301 eelkellpei rekiedakes qrsgnvaela lkatlvesst sgftpsgaga svsmiasrkp
      361 tdgasssncv tdishlvrkk rkpeeesprk ddakkakqep evnggsgdav ssgkevsenm
      421 eaeaenqaes qtaegtvesa atikstac
//
LOCUS       NP_034265                804 aa            linear   ROD 09-OCT-2023
DEFINITION  protein enabled homolog isoform 1 [Mus musculus].
ACCESSION   NP_034265
VERSION     NP_034265.2
DBSOURCE    REFSEQ: accession NM_010135.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 804)
  AUTHORS   Yun S, Cha SS and Kim JH.
  TITLE     DJ-1 promotes cell migration by interacting with Mena, the
            mammalian homolog of Drosophila enabled
  JOURNAL   Adv Biol Regul 88, 100943 (2023)
   PUBMED   36542983
  REMARK    GeneRIF: DJ-1 promotes cell migration by interacting with Mena, the
            mammalian homolog of Drosophila enabled.
REFERENCE   2  (residues 1 to 804)
  AUTHORS   Wang W, Taufalele PV, Millet M, Homsy K, Smart K, Berestesky ED,
            Schunk CT, Rowe MM, Bordeleau F and Reinhart-King CA.
  TITLE     Matrix stiffness regulates tumor cell intravasation through
            expression and ESRP1-mediated alternative splicing of MENA
  JOURNAL   Cell Rep 42 (4), 112338 (2023)
   PUBMED   37027295
  REMARK    GeneRIF: Matrix stiffness regulates tumor cell intravasation
            through expression and ESRP1-mediated alternative splicing of MENA.
REFERENCE   3  (residues 1 to 804)
  AUTHORS   Borriello L, Coste A, Traub B, Sharma VP, Karagiannis GS, Lin Y,
            Wang Y, Ye X, Duran CL, Chen X, Friedman M, Sosa MS, Sun D, Dalla
            E, Singh DK, Oktay MH, Aguirre-Ghiso JA, Condeelis JS and Entenberg
            D.
  TITLE     Primary tumor associated macrophages activate programs of invasion
            and dormancy in disseminating tumor cells
  JOURNAL   Nat Commun 13 (1), 626 (2022)
   PUBMED   35110548
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 804)
  AUTHORS   Hooper JE, Jones KL, Smith FJ, Williams T and Li H.
  TITLE     An Alternative Splicing Program for Mouse Craniofacial Development
  JOURNAL   Front Physiol 11, 1099 (2020)
   PUBMED   33013468
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 804)
  AUTHORS   Lee S, Sears MJ, Zhang Z, Li H, Salhab I, Krebs P, Xing Y, Nah HD,
            Williams T and Carstens RP.
  TITLE     Cleft lip and cleft palate in Esrp1 knockout mice is associated
            with alterations in epithelial-mesenchymal crosstalk
  JOURNAL   Development 147 (21) (2020)
   PUBMED   32253237
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 804)
  AUTHORS   Ermekova KS, Zambrano N, Linn H, Minopoli G, Gertler F, Russo T and
            Sudol M.
  TITLE     The WW domain of neural protein FE65 interacts with proline-rich
            motifs in Mena, the mammalian homolog of Drosophila enabled
  JOURNAL   J Biol Chem 272 (52), 32869-32877 (1997)
   PUBMED   9407065
REFERENCE   7  (residues 1 to 804)
  AUTHORS   Bedford MT, Chan DC and Leder P.
  TITLE     FBP WW domains and the Abl SH3 domain bind to a specific class of
            proline-rich ligands
  JOURNAL   EMBO J 16 (9), 2376-2383 (1997)
   PUBMED   9171351
REFERENCE   8  (residues 1 to 804)
  AUTHORS   Yamabhai M and Kay BK.
  TITLE     Examining the specificity of Src homology 3 domain--ligand
            interactions with alkaline phosphatase fusion proteins
  JOURNAL   Anal Biochem 247 (1), 143-151 (1997)
   PUBMED   9126384
REFERENCE   9  (residues 1 to 804)
  AUTHORS   Gertler FB, Niebuhr K, Reinhard M, Wehland J and Soriano P.
  TITLE     Mena, a relative of VASP and Drosophila Enabled, is implicated in
            the control of microfilament dynamics
  JOURNAL   Cell 87 (2), 227-239 (1996)
   PUBMED   8861907
REFERENCE   10 (residues 1 to 804)
  AUTHORS   Sazuka T, Tomooka Y, Kathju S, Ikawa Y, Noda M and Kumar S.
  TITLE     Identification of a developmentally regulated gene in the mouse
            central nervous system which encodes a novel proline rich protein
  JOURNAL   Biochim Biophys Acta 1132 (3), 240-248 (1992)
   PUBMED   1420303
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122204.3 and AC165229.7.
            
            On Mar 20, 2007 this sequence version replaced NP_034265.1.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U72523.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..804
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 84.93 cM"
     Protein         1..804
                     /product="protein enabled homolog isoform 1"
                     /note="protein enabled homolog; NPC derived proline rich
                     protein 1"
                     /calculated_mol_wt=85922
     Region          5..112
                     /region_name="EVH1_Ena_VASP-like"
                     /note="Enabled/VASP family EVH1 domain; cd01207"
                     /db_xref="CDD:269918"
     Site            order(16,23,69,71,77,79,81)
                     /site_type="other"
                     /note="proline-rich peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:269918"
     Region          143..166
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q03173.2)"
     Site            144
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:15345747; propagated from
                     UniProtKB/Swiss-Prot (Q03173.2)"
     Region          175..209
                     /region_name="7 X 5 AA tandem repeats of
                     [LM]-E-[QR]-[EQ]-[QR]"
                     /note="propagated from UniProtKB/Swiss-Prot (Q03173.2)"
     Region          245..287
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q03173.2)"
     Site            255
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKA.
                     /evidence=ECO:0000269|PubMed:15066263,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q03173.2)"
     Region          <321..541
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Site            383
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q03173.2)"
     Site            559
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000269|PubMed:12672821; propagated from
                     UniProtKB/Swiss-Prot (Q03173.2)"
     Region          619..645
                     /region_name="WH2_hVASP-like"
                     /note="Wiskott-Aldrich syndrome protein (WASP)-homology
                     domain 2 (WH2) of human Vasodilator-stimulated
                     phosphoprotein and related proteins; cd22185"
                     /db_xref="CDD:409225"
     Region          625..801
                     /region_name="EVH2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q03173.2)"
     Region          625..645
                     /region_name="EVH2 block A"
                     /note="propagated from UniProtKB/Swiss-Prot (Q03173.2)"
     Site            order(626..627,629..630,633,635..639)
                     /site_type="other"
                     /note="actin-binding motif [polypeptide binding]"
                     /db_xref="CDD:409225"
     Region          634..637
                     /region_name="KLKR"
                     /note="propagated from UniProtKB/Swiss-Prot (Q03173.2)"
     Region          635..638
                     /region_name="actin-binding sequence"
                     /note="actin-binding sequence [structural motif]"
                     /db_xref="CDD:409225"
     Region          641..677
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q03173.2)"
     Region          676..693
                     /region_name="EVH2 block B"
                     /note="propagated from UniProtKB/Swiss-Prot (Q03173.2)"
     Region          693..766
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q03173.2)"
     Site            740
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8N8S7; propagated from
                     UniProtKB/Swiss-Prot (Q03173.2)"
     Site            742
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8N8S7; propagated from
                     UniProtKB/Swiss-Prot (Q03173.2)"
     Region          765..800
                     /region_name="VASP_tetra"
                     /note="VASP tetramerisation domain; pfam08776"
                     /db_xref="CDD:430211"
     Region          767..801
                     /region_name="EVH2 block C"
                     /note="propagated from UniProtKB/Swiss-Prot (Q03173.2)"
     CDS             1..804
                     /gene="Enah"
                     /gene_synonym="Mena; NDPP-1; Ndpp1; WBP8"
                     /coded_by="NM_010135.4:449..2863"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS35811.1"
                     /db_xref="GeneID:13800"
                     /db_xref="MGI:MGI:108360"
ORIGIN      
        1 mseqsicqar aavmvyddan kkwvpaggst gfsrvhiyhh tgnntfrvvg rkiqdhqvvi
       61 ncaipkglky nqatqtfhqw rdarqvygln fgskedanvf asammhalev lnsqeaaqsk
      121 vtatqdstnl rcifcgptlp rqnsqlpaqv qngpsqeele iqrrqlqeqq rqkelererm
      181 ererlererl ererlererl eqeqlerqrq erehverler erlerlerer qerererleq
      241 lereqvewer errmsnaaps sdsslssapl peysscqpps apppsyakvi sapvsdatpd
      301 yavvtalppt stpptpplrh aatrfatslg safhpvlphy atvprplnkn srpsspvntp
      361 ssqppaaksc awptsnfspl ppsppimiss ppgkatgprp vlpvcvsspv pqmppsptap
      421 ngsldsvtyp vsppptsgpa appppppppp pppppppplp ppplpplasl shcgsqaspp
      481 pgtplastps skpsvlpsps aaapasaetp lnpelgdssa sepglqaasq paesptpqgl
      541 vlgppapppp pplpsgpaya salppppgpp pppplpstgp pppppppppl pnqapppppp
      601 ppapplpasg ifsgstsedn rpltglaaai agaklrkvsr vedgsfpggg ntgsvslass
      661 kadagrgngp lplggsglme emsallarrr riaekgstie teqkedrned aepitakaps
      721 tstpeptrkp wertntmngs kspvisrpks tpssqpsang vqtegldydr lkqdildemr
      781 kelaklkeel idairqelsk snta
//
LOCUS       NP_036050                657 aa            linear   ROD 09-OCT-2023
DEFINITION  broad substrate specificity ATP-binding cassette transporter ABCG2
            [Mus musculus].
ACCESSION   NP_036050
VERSION     NP_036050.1
DBSOURCE    REFSEQ: accession NM_011920.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 657)
  AUTHORS   Notsu T, Kurata Y, Ninomiya H, Taufiq F, Komatsu K, Miake J, Sawano
            T, Tsuneto M, Shirayoshi Y and Hisatome I.
  TITLE     Inhibition of the uric acid efflux transporter ABCG2 enhances
            stimulating effect of soluble uric acid on IL-1beta production in
            murine macrophage-like J774.1 cells
  JOURNAL   Hypertens Res 46 (10), 2368-2377 (2023)
   PUBMED   37592041
  REMARK    GeneRIF: Inhibition of the uric acid efflux transporter ABCG2
            enhances stimulating effect of soluble uric acid on IL-1beta
            production in murine macrophage-like J774.1 cells.
REFERENCE   2  (residues 1 to 657)
  AUTHORS   Harby SA, Khalil NA, El-Sayed NS, Thabet EH, Saleh SR and Fathelbab
            MH.
  TITLE     Implications of BCRP modulation on PTZ-induced seizures in mice:
            Role of ko143 and metformin as adjuvants to lamotrigine
  JOURNAL   Naunyn Schmiedebergs Arch Pharmacol 396 (10), 2627-2636 (2023)
   PUBMED   37067582
  REMARK    GeneRIF: Implications of BCRP modulation on PTZ-induced seizures in
            mice: Role of ko143 and metformin as adjuvants to lamotrigine.
REFERENCE   3  (residues 1 to 657)
  AUTHORS   Blanco-Paniagua E, Alvarez-Fernandez L, Rodriguez-Alonso A,
            Millan-Garcia A, Alvarez AI and Merino G.
  TITLE     Role of the Abcg2 Transporter in Secretion into Milk of the
            Anthelmintic Clorsulon: Interaction with Ivermectin
  JOURNAL   Antimicrob Agents Chemother 67 (5), e0009523 (2023)
   PUBMED   37078871
  REMARK    GeneRIF: Role of the Abcg2 Transporter in Secretion into Milk of
            the Anthelmintic Clorsulon: Interaction with Ivermectin.
REFERENCE   4  (residues 1 to 657)
  AUTHORS   Wu C, Xiao Y, Wu C, Xie D, Luo M, Yao D, Chen M and Lu D.
  TITLE     Regulation of BCRP expression and sulfasalazine pharmacokinetics by
            the nuclear receptor REV-ERBalpha
  JOURNAL   Xenobiotica 53 (3), 215-222 (2023)
   PUBMED   37039301
  REMARK    GeneRIF: Regulation of BCRP expression and sulfasalazine
            pharmacokinetics by the nuclear receptor REV-ERBalpha.
REFERENCE   5  (residues 1 to 657)
  AUTHORS   Alvarez-Fernandez L, Gomez-Gomez A, Haro N, Garcia-Lino AM, Alvarez
            AI, Pozo OJ and Merino G.
  TITLE     ABCG2 transporter plays a key role in the biodistribution of
            melatonin and its main metabolites
  JOURNAL   J Pineal Res 74 (2), e12849 (2023)
   PUBMED   36562106
  REMARK    GeneRIF: ABCG2 transporter plays a key role in the biodistribution
            of melatonin and its main metabolites.
REFERENCE   6  (residues 1 to 657)
  AUTHORS   Geschwind DH, Ou J, Easterday MC, Dougherty JD, Jackson RL, Chen Z,
            Antoine H, Terskikh A, Weissman IL, Nelson SF and Kornblum HI.
  TITLE     A genetic analysis of neural progenitor differentiation
  JOURNAL   Neuron 29 (2), 325-339 (2001)
   PUBMED   11239426
REFERENCE   7  (residues 1 to 657)
  AUTHORS   Jonker JW, Smit JW, Brinkhuis RF, Maliepaard M, Beijnen JH,
            Schellens JH and Schinkel AH.
  TITLE     Role of breast cancer resistance protein in the bioavailability and
            fetal penetration of topotecan
  JOURNAL   J Natl Cancer Inst 92 (20), 1651-1656 (2000)
   PUBMED   11036110
REFERENCE   8  (residues 1 to 657)
  AUTHORS   Schriml LM and Dean M.
  TITLE     Identification of 18 mouse ABC genes and characterization of the
            ABC superfamily in Mus musculus
  JOURNAL   Genomics 64 (1), 24-31 (2000)
   PUBMED   10708515
REFERENCE   9  (residues 1 to 657)
  AUTHORS   Allen JD, Brinkhuis RF, Wijnholds J and Schinkel AH.
  TITLE     The mouse Bcrp1/Mxr/Abcp gene: amplification and overexpression in
            cell lines selected for resistance to topotecan, mitoxantrone, or
            doxorubicin
  JOURNAL   Cancer Res 59 (17), 4237-4241 (1999)
   PUBMED   10485464
REFERENCE   10 (residues 1 to 657)
  AUTHORS   Allikmets R, Schriml LM, Hutchinson A, Romano-Spica V and Dean M.
  TITLE     A human placenta-specific ATP-binding cassette gene (ABCP) on
            chromosome 4q22 that is involved in multidrug resistance
  JOURNAL   Cancer Res 58 (23), 5337-5339 (1998)
   PUBMED   9850061
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121855.3, CO039662.1, AC121859.2, AK087830.1, AF103875.1 and
            AI428558.1.
            
            Summary: The membrane-associated protein encoded by this gene is
            included in the superfamily of ATP-binding cassette (ABC)
            transporters. ABC proteins transport various molecules across
            extra- and intra-cellular membranes. ABC genes are divided into
            seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,
            White). This protein is a member of the White subfamily.
            Alternatively referred to as a breast cancer resistance protein,
            the human protein functions as a xenobiotic transporter which may
            play a major role in multi-drug resistance. This protein likely
            serves as a cellular defense mechanism in response to mitoxantrone
            and anthracycline exposure. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no full-length transcript from the
            C57BL/6J reference strain was available. The extent of this
            transcript is supported by its existence in a single strain,
            C57BL/6NCrl.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053730.1, SRR7652917.858451.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..657
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 27.82 cM"
     Protein         1..657
                     /product="broad substrate specificity ATP-binding cassette
                     transporter ABCG2"
                     /EC_number="7.6.2.2"
                     /note="mitoxantrone resistance protein 1; ATP-binding
                     cassette sub-family G member 2; breast cancer resistance
                     protein 1 homolog; urate exporter; ATP-binding cassette,
                     sub-family G (WHITE), member 2"
                     /calculated_mol_wt=72891
     Region          1..24
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TMS5.1)"
     Region          46..651
                     /region_name="3a01204"
                     /note="The Eye Pigment Precursor Transporter (EPP) Family
                     protein; TIGR00955"
                     /db_xref="CDD:273361"
     Site            394..414
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TMS5.1)"
     Site            429..449
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TMS5.1)"
     Site            478..498
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TMS5.1)"
     Site            507..527
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TMS5.1)"
     Site            536..556
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TMS5.1)"
     Site            596
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TMS5.1)"
     Site            600
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TMS5.1)"
     Site            633..653
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TMS5.1)"
     CDS             1..657
                     /gene="Abcg2"
                     /gene_synonym="ABC15; ABCP; BCRP; Bcrp1; MXR; MXR1"
                     /coded_by="NM_011920.3:457..2430"
                     /db_xref="CCDS:CCDS20195.1"
                     /db_xref="GeneID:26357"
                     /db_xref="MGI:MGI:1347061"
ORIGIN      
        1 msssndhvlv pmsqrnnngl prmnsravrt laegdvlsfh hityrvkvks gflvrktvek
       61 eilsdingim kpglnailgp tgggksslld vlaarkdpkg lsgdvlinga pqpahfkccs
      121 gyvvqddvvm gtltvrenlq fsaalrlptt mknhekneri ntiikelgle kvadskvgtq
      181 firgisgger krtsigmeli tdpsilflde pttgldssta navllllkrm skqgrtiifs
      241 ihqprysifk lfdsltllas gklvfhgpaq kaleyfasag yhcepynnpa dffldvingd
      301 ssavmlnree qdneanktee pskgekpvie nlsefyinsa iygetkaeld qlpgaqekkg
      361 tsafkepvyv tsfchqlrwi arrsfknllg npqasvaqli vtvilgliig aiyfdlkyda
      421 agmqnragvl fflttnqcfs svsavelfvv ekklfiheyi sgyyrvssyf fgkvmsdllp
      481 mrflpsvift cilyfmlglk ktvdaffimm ftlimvayta ssmalaiatg qsvvsvatll
      541 mtiafvfmml fsgllvnlrt igpwlswlqy fsiprygfta lqyneflgqe fcpgfnvtdn
      601 stcvnsyaic tgneylinqg ielspwglwk nhvalacmii ifltiaylkl lflkkys
//
LOCUS       NP_032999                168 aa            linear   ROD 09-OCT-2023
DEFINITION  pleiotrophin precursor [Mus musculus].
ACCESSION   NP_032999
VERSION     NP_032999.1
DBSOURCE    REFSEQ: accession NM_008973.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 168)
  AUTHORS   Li H, Xu L, Jiang W, Qiu X, Xu H, Zhu F, Hu Y, Liang S, Cai C, Qiu
            W, Lu Z, Cui Y and Tang C.
  TITLE     Pleiotrophin ameliorates age-induced adult hippocampal neurogenesis
            decline and cognitive dysfunction
  JOURNAL   Cell Rep 42 (9), 113022 (2023)
   PUBMED   37610873
  REMARK    GeneRIF: Pleiotrophin ameliorates age-induced adult hippocampal
            neurogenesis decline and cognitive dysfunction.
REFERENCE   2  (residues 1 to 168)
  AUTHORS   Zhou Y, Li H, Liu X, Chi X, Gu Z, Cui B, Bergquist J, Wang B, Tian
            G, Yang C, Xu F and Mi J.
  TITLE     The Combination of Quantitative Proteomics and Systems Genetics
            Analysis Reveals that PTN Is Associated with Sleep-Loss-Induced
            Cognitive Impairment
  JOURNAL   J Proteome Res 22 (9), 2936-2949 (2023)
   PUBMED   37611228
  REMARK    GeneRIF: The Combination of Quantitative Proteomics and Systems
            Genetics Analysis Reveals that PTN Is Associated with
            Sleep-Loss-Induced Cognitive Impairment.
REFERENCE   3  (residues 1 to 168)
  AUTHORS   Ganguly D, Schmidt MO, Coleman M, Ngo TC, Sorrelle N, Dominguez
            ATA, Murimwa GZ, Toombs JE, Lewis C, Fang YV, Valdes-Mora F,
            Gallego-Ortega D, Wellstein A and Brekken RA.
  TITLE     Pleiotrophin drives a prometastatic immune niche in breast cancer
  JOURNAL   J Exp Med 220 (5) (2023)
   PUBMED   36828390
  REMARK    GeneRIF: Pleiotrophin drives a prometastatic immune niche in breast
            cancer.
REFERENCE   4  (residues 1 to 168)
  AUTHORS   Wang X, Zhou D, Zhou W, Liu J, Xue Q, Huang Y, Cheng C, Wang Y,
            Chang J, Wang P and Miao C.
  TITLE     Clematichinenoside AR inhibits the pathology of rheumatoid
            arthritis by blocking the circPTN/miR-145-5p/FZD4 signal axis
  JOURNAL   Int Immunopharmacol 113 (Pt A), 109376 (2022)
   PUBMED   36279670
  REMARK    GeneRIF: Clematichinenoside AR inhibits the pathology of rheumatoid
            arthritis by blocking the circPTN/miR-145-5p/FZD4 signal axis.
REFERENCE   5  (residues 1 to 168)
  AUTHORS   Drake KA, Chaney C, Patel M, Das A, Bittencourt J, Cohn M and
            Carroll TJ.
  TITLE     Transcription Factors YAP/TAZ and SRF Cooperate To Specify Renal
            Myofibroblasts in the Developing Mouse Kidney
  JOURNAL   J Am Soc Nephrol 33 (9), 1694-1707 (2022)
   PUBMED   35918150
  REMARK    Erratum:[J Am Soc Nephrol. 2023 Mar 1;34(3):515-516. PMID:
            36857501]
REFERENCE   6  (residues 1 to 168)
  AUTHORS   Li YS, Hoffman RM, Le Beau MM, Espinosa R 3rd, Jenkins NA, Gilbert
            DJ, Copeland NG and Deuel TF.
  TITLE     Characterization of the human pleiotrophin gene. Promoter region
            and chromosomal localization
  JOURNAL   J Biol Chem 267 (36), 26011-26016 (1992)
   PUBMED   1464612
REFERENCE   7  (residues 1 to 168)
  AUTHORS   Katoh K, Takeshita S, Sato M, Ito T and Amann E.
  TITLE     Genomic organization of the mouse OSF-1 gene
  JOURNAL   DNA Cell Biol 11 (10), 735-743 (1992)
   PUBMED   1457042
REFERENCE   8  (residues 1 to 168)
  AUTHORS   Nurcombe V, Fraser N, Herlaar E and Heath JK.
  TITLE     MK: a pluripotential embryonic stem-cell-derived neuroregulatory
            factor
  JOURNAL   Development 116 (4), 1175-1183 (1992)
   PUBMED   1295735
REFERENCE   9  (residues 1 to 168)
  AUTHORS   Li YS, Gurrieri M and Deuel TF.
  TITLE     Pleiotrophin gene expression is highly restricted and is regulated
            by platelet-derived growth factor
  JOURNAL   Biochem Biophys Res Commun 184 (1), 427-432 (1992)
   PUBMED   1373617
REFERENCE   10 (residues 1 to 168)
  AUTHORS   Naito A, Yoshikura H and Iwamoto A.
  TITLE     Similarity of the genomic structure between the two members in a
            new family of heparin-binding factors
  JOURNAL   Biochem Biophys Res Commun 183 (2), 701-707 (1992)
   PUBMED   1550576
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK011346.1, AK011699.1 and AI838962.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061695.1, AK011346.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..168
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 15.48 cM"
     Protein         1..168
                     /product="pleiotrophin precursor"
                     /note="osteoblast-specific factor 1; heparin-binding
                     neutrophic factor; heparin-binding brain mitogen;
                     heparin-binding growth factor 8; heparin-binding
                     growth-associated molecule"
                     /calculated_mol_wt=15299
     sig_peptide     1..32
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=3588
     mat_peptide     33..168
                     /product="Pleiotrophin. /id=PRO_0000024660"
                     /note="propagated from UniProtKB/Swiss-Prot (P63089.1)"
                     /calculated_mol_wt=15299
     Region          47..131
                     /region_name="PTN_MK_N"
                     /note="PTN/MK heparin-binding protein family, N-terminal
                     domain; cl02505"
                     /db_xref="CDD:445801"
     Region          92..99
                     /region_name="Chondroitin sulfate binding.
                     /evidence=ECO:0000250|UniProtKB:P21246"
                     /note="propagated from UniProtKB/Swiss-Prot (P63089.1)"
     Region          123..131
                     /region_name="Chondroitin sulfate binding.
                     /evidence=ECO:0000250|UniProtKB:P21246"
                     /note="propagated from UniProtKB/Swiss-Prot (P63089.1)"
     Region          139..168
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P63089.1)"
     Region          147..168
                     /region_name="Chondroitin sulfate A binding.
                     /evidence=ECO:0000250|UniProtKB:P21246"
                     /note="propagated from UniProtKB/Swiss-Prot (P63089.1)"
     CDS             1..168
                     /gene="Ptn"
                     /gene_synonym="HARP; HB-GAM; HBBM; HBBN; HBGF-8; HBNF;
                     OSF; Osf-1; Osf1"
                     /coded_by="NM_008973.3:289..795"
                     /db_xref="CCDS:CCDS20005.1"
                     /db_xref="GeneID:19242"
                     /db_xref="MGI:MGI:97804"
ORIGIN      
        1 mssqqyqqqr rkfaaaflal ifilaavdta eagkkekpek kvkksdcgew qwsvcvptsg
       61 dcglgtregt rtgaeckqtm ktqrckipcn wkkqfgaeck yqfqawgecd lntalktrtg
      121 slkralhnad cqktvtiskp cgkltkpkpq aeskkkkkeg kkqekmld
//
LOCUS       NP_918944                681 aa            linear   ROD 09-OCT-2023
DEFINITION  epithelial splicing regulatory protein 1 isoform 1 [Mus musculus].
ACCESSION   NP_918944
VERSION     NP_918944.2
DBSOURCE    REFSEQ: accession NM_194055.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 681)
  AUTHORS   Wang W, Taufalele PV, Millet M, Homsy K, Smart K, Berestesky ED,
            Schunk CT, Rowe MM, Bordeleau F and Reinhart-King CA.
  TITLE     Matrix stiffness regulates tumor cell intravasation through
            expression and ESRP1-mediated alternative splicing of MENA
  JOURNAL   Cell Rep 42 (4), 112338 (2023)
   PUBMED   37027295
  REMARK    GeneRIF: Matrix stiffness regulates tumor cell intravasation
            through expression and ESRP1-mediated alternative splicing of MENA.
REFERENCE   2  (residues 1 to 681)
  AUTHORS   Zhao Y, Li M, Wu W, Miao W and Liu H.
  TITLE     Downregulated ESRP1/2 promotes lung metastasis of bladder carcinoma
            through altering FGFR2 splicing and macrophage polarization
  JOURNAL   Front Immunol 14, 1161273 (2023)
   PUBMED   37090731
  REMARK    GeneRIF: Downregulated ESRP1/2 promotes lung metastasis of bladder
            carcinoma through altering FGFR2 splicing and macrophage
            polarization.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 681)
  AUTHORS   Peart NJ, Hwang JY, Quesnel-Vallieres M, Sears MJ, Yang Y, Stoilov
            P, Barash Y, Park JW, Lynch KW and Carstens RP.
  TITLE     The global Protein-RNA interaction map of ESRP1 defines a
            post-transcriptional program that is essential for epithelial cell
            function
  JOURNAL   iScience 25 (10), 105205 (2022)
   PUBMED   36238894
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 681)
  AUTHORS   Spruce T, Plass M, Gohr A, Ray D, Martinez de Lagran M, Rot G,
            Novoa A, Burguera D, Permanyer J, Miret M, Zheng H, Swanson MS,
            Morris Q, Mallo M, Dierssen M, Hughes TR, Pernaute B and Irimia M.
  TITLE     The X-linked splicing regulator MBNL3 has been co-opted to restrict
            placental growth in eutherians
  JOURNAL   PLoS Biol 20 (4), e3001615 (2022)
   PUBMED   35476669
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 681)
  AUTHORS   Yu L, Zhang H, Guan X, Qin D, Zhou J and Wu X.
  TITLE     Loss of ESRP1 blocks mouse oocyte development and leads to female
            infertility
  JOURNAL   Development 148 (2) (2021)
   PUBMED   33318146
  REMARK    GeneRIF: Loss of ESRP1 blocks mouse oocyte development and leads to
            female infertility.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 681)
  AUTHORS   Warzecha CC, Sato TK, Nabet B, Hogenesch JB and Carstens RP.
  TITLE     ESRP1 and ESRP2 are epithelial cell-type-specific regulators of
            FGFR2 splicing
  JOURNAL   Mol Cell 33 (5), 591-601 (2009)
   PUBMED   19285943
  REMARK    GeneRIF: Epithelial splicing regulatory proteins 1/2 (ESRP1/2) are
            epithelial cell-type-specific regulators of FGFR2 splicing.
REFERENCE   7  (residues 1 to 681)
  AUTHORS   Sherwood RI, Jitianu C, Cleaver O, Shaywitz DA, Lamenzo JO, Chen
            AE, Golub TR and Melton DA.
  TITLE     Prospective isolation and global gene expression analysis of
            definitive and visceral endoderm
  JOURNAL   Dev Biol 304 (2), 541-555 (2007)
   PUBMED   17328885
REFERENCE   8  (residues 1 to 681)
  AUTHORS   Evsikov AV, Graber JH, Brockman JM, Hampl A, Holbrook AE, Singh P,
            Eppig JJ, Solter D and Knowles BB.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   9  (residues 1 to 681)
  AUTHORS   McKee AE, Minet E, Stern C, Riahi S, Stiles CD and Silver PA.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   10 (residues 1 to 681)
  AUTHORS   Piao Y, Ko NT, Lim MK and Ko MS.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK140848.1, CJ081693.1, AK042164.1, DV657411.1, DV648780.1 and
            AA647208.1.
            
            On Jan 19, 2008 this sequence version replaced NP_918944.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..681
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 5.11 cM"
     Protein         1..681
                     /product="epithelial splicing regulatory protein 1 isoform
                     1"
                     /note="RNA binding motif protein 35A"
                     /calculated_mol_wt=75506
     Region          29..>145
                     /region_name="DnaQ_like_exo"
                     /note="DnaQ-like (or DEDD) 3'-5' exonuclease domain
                     superfamily; cl10012"
                     /db_xref="CDD:447876"
     Region          216..308
                     /region_name="RRM_SF"
                     /note="RNA recognition motif (RRM) superfamily; cl17169"
                     /db_xref="CDD:450164"
     Region          310..419
                     /region_name="RRM2_ESRP1"
                     /note="RNA recognition motif 2 (RRM2) found in epithelial
                     splicing regulatory protein 1 (ESRP1) and similar
                     proteins; cd12739"
                     /db_xref="CDD:410136"
     Region          444..524
                     /region_name="RRM3_ESRP1_ESRP2"
                     /note="RNA recognition motif 3 (RRM3) found in epithelial
                     splicing regulatory protein ESRP1, ESRP2 and similar
                     proteins; cd12742"
                     /db_xref="CDD:410138"
     Site            543
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H6T0; propagated from
                     UniProtKB/Swiss-Prot (Q3US41.2)"
     Site            582
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:Q6NXG1; propagated from
                     UniProtKB/Swiss-Prot (Q3US41.2)"
     Region          633..>672
                     /region_name="RRM_SF"
                     /note="RNA recognition motif (RRM) superfamily; cl17169"
                     /db_xref="CDD:450164"
     CDS             1..681
                     /gene="Esrp1"
                     /gene_synonym="2210008M09Rik; A630065D16; Rbm35a"
                     /coded_by="NM_194055.3:348..2393"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS51119.1"
                     /db_xref="GeneID:207920"
                     /db_xref="MGI:MGI:1917326"
ORIGIN      
        1 mtaspdylvv lfgitagatg aklgsdekel illlwkvvdl ankkvgqlhe vlvrpdqlel
       61 tedckeetki daenlssapq ldqalrqfnq svsnelnigv gtsfclctdg qlhirqilhp
      121 easkknvllp ecfysffdlr kefkkccpgs pdidkldvaa mteslnfeks dsvsrygasq
      181 vedmgniila misepynhrf sdpervnykf esgtcskmel iddstvvrar glpwqssdqd
      241 iarffkglni akggaalcln aqgrrngeal vrfvseehrd lalqrhkhhm gtryievyka
      301 tgedflkiag gtsnevaqfl skenqvivrm rglpftatae evvaffgqhc pitggkegil
      361 fvtypdgrpt gdafvlface eyaqnalrkh kellgkryie lfrstaaevq qvlnrfssap
      421 liplptppii pvlpqqfvpp tnvrdcirlr glpyaatied ildflgefst dirthgvhmv
      481 lnhqgrpsgd afiqmkstdr afmaaqkyhk ktmkdryvev fqcsaeemnf vlmggtlnrn
      541 glspppcklp clsppsytfp aptaviptea aiyqpsllln pralqpstay ypagtqlfmn
      601 ytayypsppg spnslgyfpt aanlssvppq pgtvvrmqgl ayntgvkeil nffqgyqyat
      661 edglvhtndq artlpkewvc i
//
LOCUS       NP_001297449            1167 aa            linear   ROD 09-OCT-2023
DEFINITION  zinc finger protein 423 isoform 2 [Mus musculus].
ACCESSION   NP_001297449 XP_006531603
VERSION     NP_001297449.1
DBSOURCE    REFSEQ: accession NM_001310520.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1167)
  AUTHORS   Roth L, Johann K, Hones GS, Oelkrug R, Wagner L, Hoffmann A, Krohn
            K, Moeller LC, Weiner J, Heiker JT, Kloting N, Tonjes A, Stumvoll
            M, Bluher M, Mittag J and Krause K.
  TITLE     Thyroid hormones regulate Zfp423 expression in regionally distinct
            adipose depots through direct and cell-autonomous action
  JOURNAL   Cell Rep 42 (2), 112088 (2023)
   PUBMED   36753417
  REMARK    GeneRIF: Thyroid hormones regulate Zfp423 expression in regionally
            distinct adipose depots through direct and cell-autonomous action.
REFERENCE   2  (residues 1 to 1167)
  AUTHORS   Shao M, Zhang Q, Truong A, Shan B, Vishvanath L, Li L, Seale P and
            Gupta RK.
  TITLE     ZFP423 controls EBF2 coactivator recruitment and PPARgamma
            occupancy to determine the thermogenic plasticity of adipocytes
  JOURNAL   Genes Dev 35 (21-22), 1461-1474 (2021)
   PUBMED   34620682
  REMARK    GeneRIF: ZFP423 controls EBF2 coactivator recruitment and PPARgamma
            occupancy to determine the thermogenic plasticity of adipocytes.
REFERENCE   3  (residues 1 to 1167)
  AUTHORS   Han S, Okawa S, Wilkinson GA, Ghazale H, Adnani L, Dixit R, Tavares
            L, Faisal I, Brooks MJ, Cortay V, Zinyk D, Sivitilli A, Li S, Malik
            F, Ilnytskyy Y, Angarica VE, Gao J, Chinchalongporn V, Oproescu AM,
            Vasan L, Touahri Y, David LA, Raharjo E, Kim JW, Wu W, Rahmani W,
            Chan JA, Kovalchuk I, Attisano L, Kurrasch D, Dehay C, Swaroop A,
            Castro DS, Biernaskie J, Del Sol A and Schuurmans C.
  TITLE     Proneural genes define ground-state rules to regulate neurogenic
            patterning and cortical folding
  JOURNAL   Neuron 109 (18), 2847-2863 (2021)
   PUBMED   34407390
REFERENCE   4  (residues 1 to 1167)
  AUTHORS   Casoni F, Croci L, Vincenti F, Podini P, Riba M, Massimino L,
            Cremona O and Consalez GG.
  TITLE     ZFP423 regulates early patterning and multiciliogenesis in the
            hindbrain choroid plexus
  JOURNAL   Development 147 (22) (2020)
   PUBMED   33046507
  REMARK    GeneRIF: ZFP423 regulates early patterning and multiciliogenesis in
            the hindbrain choroid plexus.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1167)
  AUTHORS   Alcaraz WA, Liu Z, Valdes P, Chen E, Valdovino Gonzalez AG, Wade S,
            Wong C, Kim E, Chen HM, Ponn A, Concepcion D and Hamilton BA.
  TITLE     Strain-Dependent Modifier Genes Determine Survival in Zfp423 Mice
  JOURNAL   G3 (Bethesda) 10 (11), 4241-4247 (2020)
   PUBMED   32967895
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1167)
  AUTHORS   Warming S, Liu P, Suzuki T, Akagi K, Lindtner S, Pavlakis GN,
            Jenkins NA and Copeland NG.
  TITLE     Evi3, a common retroviral integration site in murine B-cell
            lymphoma, encodes an EBFAZ-related Kruppel-like zinc finger protein
  JOURNAL   Blood 101 (5), 1934-1940 (2003)
   PUBMED   12393497
REFERENCE   7  (residues 1 to 1167)
  AUTHORS   Okazaki N, Kikuno R, Ohara R, Inamoto S, Aizawa H, Yuasa S,
            Nakajima D, Nagase T, Ohara O and Koga H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   8  (residues 1 to 1167)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (residues 1 to 1167)
  AUTHORS   Araki K, Imaizumi T, Sekimoto T, Yoshinobu K, Yoshimuta J, Akizuki
            M, Miura K, Araki M and Yamamura K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   10 (residues 1 to 1167)
  AUTHORS   Tsai RY and Reed RR.
  TITLE     Cloning and functional characterization of Roaz, a zinc finger
            protein that interacts with O/E-1 to regulate gene expression:
            implications for olfactory neuronal development
  JOURNAL   J Neurosci 17 (11), 4159-4169 (1997)
   PUBMED   9151733
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK133497.1, BC079586.1 and AI845255.1.
            
            On Jul 15, 2015 this sequence version replaced XP_006531603.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and uses a downstream start codon
            compared to variant 1. It encodes isoform 2, which has a shorter
            N-terminus than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK133497.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1167
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 42.29 cM"
     Protein         1..1167
                     /product="zinc finger protein 423 isoform 2"
                     /note="early B-cell factor associated zinc finger protein;
                     olf1/EBF-associated zinc finger protein; smad- and
                     Olf-interacting zinc finger protein; zinc finger protein
                     104; early B-cell factor associated zinc finger
                     transcription factor"
                     /calculated_mol_wt=131449
     Region          23..43
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(23,26,39,43)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:275368"
     Site            order(28,30,32,34..35,38..39,42,56,58,62..63,66..67,70,84,
                     86,88,90..91,94..95,98)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          51..71
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          77..478
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          79..99
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          107..127
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          148..167
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          294..315
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(294,297,311,315)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:275368"
     Site            order(299,302,304,306..307,310..311,314,331,333,337..338,
                     341..342,349,370,372,374,376..377,380..381,384)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          326..350
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          365..384
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          547..567
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(547,550,563,567)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:275368"
     Region          577..598
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          605..626
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(605,608,621,626)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:275368"
     Site            order(610,612,614,616..617,620..621,624,640,642,646..647,
                     650..651,655,671,673,675,677..678,681..682,685)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          635..656
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          666..686
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          692..710
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          771..792
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(771,774,787,792)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:275368"
     Region          815..835
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(815,818,831,835)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:275368"
     Region          844..864
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          1083..1103
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(1083,1086,1099,1103)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:275368"
     Site            order(1088,1090,1092,1094..1095,1098..1099,1102,1119,1121,
                     1125..1126,1129..1130,1134,1149,1151,1153,1155..1156,
                     1159..1160)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          1114..1135
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          1144..1160
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..1167
                     /gene="Zfp423"
                     /gene_synonym="ataxia1; Ebfaz; mKIAA0760; nur12; Roaz;
                     Zfp104; Znf423"
                     /coded_by="NM_001310520.1:163..3666"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS80911.1"
                     /db_xref="GeneID:94187"
                     /db_xref="MGI:MGI:1891217"
ORIGIN      
        1 migdgcdlgl geeeggtglp ypcqfcdksf irlsylkrhe qihsdklpfk ctfcsrlfkh
       61 krsrdrhikl htgdkkyhch eceaafsrsd hlkihlkths sskpfkcsvc krgfsstssl
      121 qshmqahkkn kehlakseke akkddfmcdy cedtfsqtee lekhvltlhp qlsekadlqc
      181 ihcpevfvde stllahihqa hanqkhkcpm cpeqfssveg vychldshrq pdssnhsvsp
      241 dpvlgsvasm ssatpdssas vergstpdst lkplrgqkkm rddgqswpkv vyscpycskr
      301 dftslavlei hlktihadkp qqshtcqicl dsmptlynln ehvrklhksh aypvmqfgni
      361 safhcnycpe mfadinslqe hirvshcgpn anppdgnnaf fcnqcsmgfl tessltehiq
      421 qahcsvgstk lespvvqptq sfmevyscpy ctnspifgsi lkltkhiken hkniplahsk
      481 kskaeqspvs sdvevsspkr qrlsgsansi sngeypcnqc dlkfsnfesf qthlklhlel
      541 llrkqacpqc kedfdsqesl lqhltvhymt tsthyvcesc dkqfssvddl qkhlldmhtf
      601 vlyhctlcqe vfdskvsiqv hlavkhsnek kmyrctacnw dfrkeadlqv hvkhshlgnp
      661 akahkcifcg etfstevelq chitthskky ncrfcskafh avillekhlr ekhcvfdaaa
      721 engtangvpp tstkkaepad lqgmllknpe apnsheased dvdasepmyg cdicgaaytm
      781 evllqnhrlr dhnirpgedd gsrkkaefik gshkcnvcsr tffsenglre hlqthrgpak
      841 hymcpicger fpslltlteh kvthsksldt gtcrickmpl qseeefiehc qmhpdlrnsl
      901 tgfrcvvcmq tvtstlelki hgtfhmqkla gssaasspng qglqklykca lclkefrskq
      961 dlvrldvngl pyglcagcma rsangqvggl appepadrpc aglrcpecnv kfesaedles
     1021 hmqvdhrdlt petsgprkga qtspvprkkt yqcikcqmtf enereiqihv anhmieegin
     1081 hecklcnqmf dspakllchl iehsfegmgg tfkcpvcftv fvqanklqqh ifavhgqedk
     1141 iydcsqcpqk fffqtelqnh tmsqhaq
//
LOCUS       NP_001277686            1050 aa            linear   ROD 09-OCT-2023
DEFINITION  toll-like receptor 7 isoform a precursor [Mus musculus].
ACCESSION   NP_001277686 XP_006528777
VERSION     NP_001277686.1
DBSOURCE    REFSEQ: accession NM_001290757.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1050)
  AUTHORS   Huang Y, Liu D, Chen M, Xu S, Peng Q, Zhu Y, Long J, Liu T, Deng Z,
            Xie H, Li J, Liu F and Xiao W.
  TITLE     TLR7 promotes skin inflammation via activating NFkappaB-mTORC1 axis
            in rosacea
  JOURNAL   PeerJ 11, e15976 (2023)
   PUBMED   37780385
  REMARK    GeneRIF: TLR7 promotes skin inflammation via activating
            NFkappaB-mTORC1 axis in rosacea.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1050)
  AUTHORS   Miles MA, Liong S, Liong F, Coward-Smith M, Trollope GS, Oseghale
            O, Erlich JR, Brooks RD, Logan JM, Hickey S, Wang H, Bozinovski S,
            O'Leary JJ, Brooks DA and Selemidis S.
  TITLE     TLR7 promotes chronic airway disease in RSV-infected mice
  JOURNAL   Front Immunol 14, 1240552 (2023)
   PUBMED   37795093
  REMARK    GeneRIF: TLR7 promotes chronic airway disease in RSV-infected mice.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1050)
  AUTHORS   Cosgrove HA, Gingras S, Kim M, Bastacky S, Tilstra JS and Shlomchik
            MJ.
  TITLE     B cell-intrinsic TLR7 expression drives severe lupus in
            TLR9-deficient mice
  JOURNAL   JCI Insight 8 (16), e172219 (2023)
   PUBMED   37606042
  REMARK    GeneRIF: B cell-intrinsic TLR7 expression drives severe lupus in
            TLR9-deficient mice.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1050)
  AUTHORS   Kim J, Ha S, Son M, Kim D, Kim MJ, Kim B, Kim D, Chung HY and Chung
            KW.
  TITLE     TLR7 activation by miR-21 promotes renal fibrosis by activating the
            pro-inflammatory signaling pathway in tubule epithelial cells
  JOURNAL   Cell Commun Signal 21 (1), 215 (2023)
   PUBMED   37596656
  REMARK    GeneRIF: TLR7 activation by miR-21 promotes renal fibrosis by
            activating the pro-inflammatory signaling pathway in tubule
            epithelial cells.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1050)
  AUTHORS   Jackson WD, Giacomassi C, Ward S, Owen A, Luis TC, Spear S,
            Woollard KJ, Johansson C, Strid J and Botto M.
  TITLE     TLR7 activation at epithelial barriers promotes emergency
            myelopoiesis and lung antiviral immunity
  JOURNAL   Elife 12, e85647 (2023)
   PUBMED   37566453
  REMARK    GeneRIF: TLR7 activation at epithelial barriers promotes emergency
            myelopoiesis and lung antiviral immunity.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1050)
  AUTHORS   Heil F, Hemmi H, Hochrein H, Ampenberger F, Kirschning C, Akira S,
            Lipford G, Wagner H and Bauer S.
  TITLE     Species-specific recognition of single-stranded RNA via toll-like
            receptor 7 and 8
  JOURNAL   Science 303 (5663), 1526-1529 (2004)
   PUBMED   14976262
  REMARK    GeneRIF: mediates species-specific recognition of GU-rich
            single-stranded RNA (ssRNA); data suggest that ssRNA represents a
            physiological ligand for TLR7
REFERENCE   7  (residues 1 to 1050)
  AUTHORS   Diebold SS, Kaisho T, Hemmi H, Akira S and Reis e Sousa C.
  TITLE     Innate antiviral responses by means of TLR7-mediated recognition of
            single-stranded RNA
  JOURNAL   Science 303 (5663), 1529-1531 (2004)
   PUBMED   14976261
  REMARK    GeneRIF: results identify ssRNA as a ligand for TLR7 and suggest
            that cells of the innate immune system sense endosomal ssRNA to
            detect infection by RNA viruses
REFERENCE   8  (residues 1 to 1050)
  AUTHORS   Pinhal-Enfield G, Ramanathan M, Hasko G, Vogel SN, Salzman AL,
            Boons GJ and Leibovich SJ.
  TITLE     An angiogenic switch in macrophages involving synergy between
            Toll-like receptors 2, 4, 7, and 9 and adenosine A(2A) receptors
  JOURNAL   Am J Pathol 163 (2), 711-721 (2003)
   PUBMED   12875990
  REMARK    GeneRIF: Results suggest novel signaling pathway in murine
            macrophages involving synergy between toll-like receptors 2, 4, 7,
            and 9 and adenosine A(2A)receptors, that up-regulates VEGF and
            down-regulates TNFalpha expression, thus acting as an angiogenic
            switch.
REFERENCE   9  (residues 1 to 1050)
  AUTHORS   Jurk,M., Heil,F., Vollmer,J., Schetter,C., Krieg,A.M., Wagner,H.,
            Lipford,G. and Bauer,S.
  TITLE     Human TLR7 or TLR8 independently confer responsiveness to the
            antiviral compound R-848
  JOURNAL   Nat Immunol 3 (6), 499 (2002)
   PUBMED   12032557
REFERENCE   10 (residues 1 to 1050)
  AUTHORS   Hemmi H, Kaisho T, Takeuchi O, Sato S, Sanjo H, Hoshino K, Horiuchi
            T, Tomizawa H, Takeda K and Akira S.
  TITLE     Small anti-viral compounds activate immune cells via the TLR7
            MyD88-dependent signaling pathway
  JOURNAL   Nat Immunol 3 (2), 196-200 (2002)
   PUBMED   11812998
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL731735.14, AK036549.1 and BY543663.1.
            
            On Mar 19, 2014 this sequence version replaced XP_006528777.1.
            
            Transcript Variant: This variant (4) lacks two alternate exons and
            uses an alternate splice site in the 5' region, and initiates
            translation from an alternate upstream start codon, compared to
            variant 1. Variants 1, 2, 3, and 4 encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156908.1, AF334943.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1050
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 78.31 cM"
     Protein         1..1050
                     /product="toll-like receptor 7 isoform a precursor"
                     /note="Toll like receptor 7"
                     /calculated_mol_wt=118668
     sig_peptide     1..26
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
                     /calculated_mol_wt=3187
     Region          <32..>243
                     /region_name="PRK15370"
                     /note="type III secretion system effector E3 ubiquitin
                     transferase SlrP"
                     /db_xref="CDD:185268"
     Region          42..64
                     /region_name="LRR 1"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          48..69
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          65..87
                     /region_name="LRR 2"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Site            66
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Site            69
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Region          70..90
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          89..111
                     /region_name="LRR 3"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          91..128
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          126..149
                     /region_name="LRR 4"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          129..152
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          151..170
                     /region_name="LRR 5"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Site            167
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Region          171..195
                     /region_name="LRR 6"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          174..>786
                     /region_name="PLN00113"
                     /note="leucine-rich repeat receptor-like protein kinase;
                     Provisional"
                     /db_xref="CDD:215061"
     Region          174..205
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            190
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Region          203..226
                     /region_name="LRR 7"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          206..226
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            215
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Region          227..250
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          228..247
                     /region_name="LRR 8"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          248..273
                     /region_name="LRR 9"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          251..291
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          275..289
                     /region_name="LRR 10"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          290..312
                     /region_name="LRR 11"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          292..315
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          314..337
                     /region_name="LRR 12"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          316..341
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          339..364
                     /region_name="LRR 13"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          342..398
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          369..392
                     /region_name="LRR 14"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Site            387
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Region          396..419
                     /region_name="LRR 15"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          399..422
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          421..443
                     /region_name="LRR 16"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          493..516
                     /region_name="LRR 17"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          497..519
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          517..542
                     /region_name="LRR 18"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          520..544
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            524
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Site            535
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Region          543..565
                     /region_name="LRR 19"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          545..568
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          567..589
                     /region_name="LRR 20"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          569..598
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            591
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Region          596..619
                     /region_name="LRR 21"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          599..621
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          620..645
                     /region_name="LRR 22"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          622..652
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          650..673
                     /region_name="LRR 23"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          653..677
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          675..698
                     /region_name="LRR 24"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          678..701
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            680
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Region          699..722
                     /region_name="LRR 25"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          702..725
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            721
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Region          724..746
                     /region_name="LRR 26"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          747..770
                     /region_name="LRR 27"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          750..775
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          754..>838
                     /region_name="PCC"
                     /note="polycystin cation channel protein; TIGR00864"
                     /db_xref="CDD:188093"
     Region          773..796
                     /region_name="LRR 28"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Site            800
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Site            838..858
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          891..1036
                     /region_name="TIR"
                     /note="Toll - interleukin 1 - resistance; smart00255"
                     /db_xref="CDD:214587"
     CDS             1..1050
                     /gene="Tlr7"
                     /coded_by="NM_001290757.1:268..3420"
                     /note="isoform a precursor is encoded by transcript
                     variant 4"
                     /db_xref="CCDS:CCDS30531.1"
                     /db_xref="GeneID:170743"
                     /db_xref="MGI:MGI:2176882"
ORIGIN      
        1 mvfsmwtrkr qiliflnmll vsrvfgfrwf pktlpcevkv nipeahvivd ctdkhlteip
       61 egiptnttnl tltinhipsi spdsfrrlnh leeidlrcnc vpvllgskan vctkrlqirp
      121 gsfsglsdlk alyldgnqll eipqdlpssl hllsleanni fsitkenlte lvnietlylg
      181 qncyyrnpcn vsysiekdaf lvmrnlkvls lkdnnvtavp ttlppnllel ylynniikki
      241 qendfnnlne lqvldlsgnc prcynvpypc tpcennsplq ihdnafnslt elkvlrlhsn
      301 slqhvpptwf knmrnlqeld lsqnylarei eeakflhflp nlveldfsfn yelqvyhasi
      361 tlphslssle nlkilrvkgy vfkelknssl svlhklprle vldlgtnfik iadlnifkhf
      421 enlklidlsv nkispseesr evgfcpnaqt svdrhgpqvl ealhyfryde yarscrfknk
      481 eppsflplna dchiygqtld lsrnniffik psdfqhlsfl kclnlsgnti gqtlngselw
      541 plrelryldf snnrldllys tafeelqsle vldlssnshy fqaegithml nftkklrlld
      601 klmmndndis tsasrtmesd slrilefrgn hldvlwragd nryldffknl fnlevldisr
      661 nslnslppev fegmppnlkn lslaknglks ffwdrlqllk hleildlshn qltkvperla
      721 ncskslttli lkhnqirqlt kyfledalql ryldissnki qviqktsfpe nvlnnlemlv
      781 lhhnrflcnc davwfvwwvn htdvtipyla tdvtcvgpga hkgqsvisld lytceldltn
      841 lilfsvsiss vlflmvvmtt shlffwdmwy iyyfwkakik gyqhlqsmes cydafivydt
      901 knsavtewvl qelvakledp rekhfnlcle erdwlpgqpv lenlsqsiql skktvfvmtq
      961 kyaktesfkm afylshqrll dekvdviili flekplqksk flqlrkrlcr ssvlewpanp
     1021 qahpyfwqcl knalttdnhv aysqmfketv
//
LOCUS       NP_001351357             514 aa            linear   ROD 09-OCT-2023
DEFINITION  pro-neuregulin-1, membrane-bound isoform isoform 9 [Mus musculus].
ACCESSION   NP_001351357
VERSION     NP_001351357.1
DBSOURCE    REFSEQ: accession NM_001364428.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 514)
  AUTHORS   Mikami Y, Iwase F, Ohshima D, Tomida T and Adachi-Akahane S.
  TITLE     Compensatory role of neuregulin-1 in diabetic cardiomyopathy
  JOURNAL   J Pharmacol Sci 153 (3), 130-141 (2023)
   PUBMED   37770154
  REMARK    GeneRIF: Compensatory role of neuregulin-1 in diabetic
            cardiomyopathy.
REFERENCE   2  (residues 1 to 514)
  AUTHORS   Qiao XY, Wang Y, Zhang W, Li Q, Liu C, Dao JJ, Qiao CM, Cui C, Shen
            YQ and Zhao WJ.
  TITLE     Involvement of CXCL10 in Neuronal Damage under the Condition of
            Spinal Cord Injury and the Potential Therapeutic Effect of Nrg1
  JOURNAL   J Integr Neurosci 22 (4), 96 (2023)
   PUBMED   37519170
  REMARK    GeneRIF: Involvement of CXCL10 in Neuronal Damage under the
            Condition of Spinal Cord Injury and the Potential Therapeutic
            Effect of Nrg1.
REFERENCE   3  (residues 1 to 514)
  AUTHORS   Liu H, Lu P, He S, Luo Y, Fang Y, Benkaci S, Wu B, Wang Y and Zhou
            B.
  TITLE     beta-Catenin regulates endocardial cushion growth by suppressing
            p21
  JOURNAL   Life Sci Alliance 6 (9), e202302163 (2023)
   PUBMED   37385754
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 514)
  AUTHORS   Kong L, Hassinan CW, Gerstner F, Buettner JM, Petigrow JB, Valdivia
            DO, Chan-Cortes MH, Mistri A, Cao A, McGaugh SA, Denton M, Brown S,
            Ross J, Schwab MH, Simon CM and Sumner CJ.
  TITLE     Boosting neuregulin 1 type-III expression hastens SMA motor axon
            maturation
  JOURNAL   Acta Neuropathol Commun 11 (1), 53 (2023)
   PUBMED   36997967
  REMARK    GeneRIF: Boosting neuregulin 1 type-III expression hastens SMA
            motor axon maturation.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 514)
  AUTHORS   Zhang X, Xiao G, Johnson C, Cai Y, Horowitz ZK, Mennicke C, Coffey
            R, Haider M, Threadgill D, Eliscu R, Oldham MC, Greenbaum A and
            Ghashghaei HT.
  TITLE     Bulk and mosaic deletions of Egfr reveal regionally defined
            gliogenesis in the developing mouse forebrain
  JOURNAL   iScience 26 (3), 106242 (2023)
   PUBMED   36915679
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 514)
  AUTHORS   Gassmann M, Casagranda F, Orioli D, Simon H, Lai C, Klein R and
            Lemke G.
  TITLE     Aberrant neural and cardiac development in mice lacking the ErbB4
            neuregulin receptor
  JOURNAL   Nature 378 (6555), 390-394 (1995)
   PUBMED   7477376
REFERENCE   7  (residues 1 to 514)
  AUTHORS   Meyer,D. and Birchmeier,C.
  TITLE     Multiple essential functions of neuregulin in development
  JOURNAL   Nature 378 (6555), 386-390 (1995)
   PUBMED   7477375
  REMARK    Erratum:[Nature 1995 Dec 14;378(6558):753]
REFERENCE   8  (residues 1 to 514)
  AUTHORS   Moscoso LM, Chu GC, Gautam M, Noakes PG, Merlie JP and Sanes JR.
  TITLE     Synapse-associated expression of an acetylcholine receptor-inducing
            protein, ARIA/heregulin, and its putative receptors, ErbB2 and
            ErbB3, in developing mammalian muscle
  JOURNAL   Dev Biol 172 (1), 158-169 (1995)
   PUBMED   7589796
REFERENCE   9  (residues 1 to 514)
  AUTHORS   Yang Y, Spitzer E, Meyer D, Sachs M, Niemann C, Hartmann G, Weidner
            KM, Birchmeier C and Birchmeier W.
  TITLE     Sequential requirement of hepatocyte growth factor and neuregulin
            in the morphogenesis and differentiation of the mammary gland
  JOURNAL   J Cell Biol 131 (1), 215-226 (1995)
   PUBMED   7559778
REFERENCE   10 (residues 1 to 514)
  AUTHORS   Ho WH, Armanini MP, Nuijens A, Phillips HS and Osheroff PL.
  TITLE     Sensory and motor neuron-derived factor. A novel heregulin variant
            highly expressed in sensory and motor neurons
  JOURNAL   J Biol Chem 270 (24), 14523-14532 (1995)
   PUBMED   7782315
  REMARK    Erratum:[J Biol Chem. 1995 Nov 3;270(44):26722. PMID: 7592900]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132407.3 and AC127374.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.92693.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..514
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 18.75 cM"
     Protein         1..514
                     /product="pro-neuregulin-1, membrane-bound isoform isoform
                     9"
                     /note="heregulin; type III neuregulin 1; type I neuregulin
                     1; pro-neuregulin-1, membrane-bound isoform"
                     /calculated_mol_wt=55876
     Region          319..>476
                     /region_name="Neuregulin"
                     /note="Neuregulin family; pfam02158"
                     /db_xref="CDD:426627"
     CDS             1..514
                     /gene="Nrg1"
                     /gene_synonym="6030402G23Rik; ARIA; D230005F13Rik; GGF;
                     GGFII; Hgl; HRG; HRGalpha; NDF; Pro-NRG1; SMDF"
                     /coded_by="NM_001364428.1:641..2185"
                     /note="isoform 9 is encoded by transcript variant 9"
                     /db_xref="GeneID:211323"
                     /db_xref="MGI:MGI:96083"
ORIGIN      
        1 meiyppdmse gaggrsssps tqlsadpsld glpaaehmpd thtedgrspg llglavpccv
       61 cleaerlrgc lnsekicivp ilaclvslcl ciaglkwvfv dkifeydspt hldpgglgqd
      121 pvisldptaa savlvsseay tspvskaqse aeahvtgqgd hvavasepsa vptrknrlsa
      181 fpplhstppp fpspartpev rtpksgtqpq ttetnlqtap klstststtg tshlikcaek
      241 ektfcvngge cfmvkdlsnp srylckcpne ftgdrcqnyv masfykaeel yqkrvltitg
      301 iciallvvgi mcvvaycktk kqrqklhdrl rqslrsernn mvniangphh pnpppenvql
      361 vnqyvsknvi ssehiverev etsfstshyt stahhsttvt qtpshswsng htesiisesh
      421 svimmssven srhsspaggp rgrlhglggp recnsflrha retpdsyrds phserhnlia
      481 elrrnkayrs kcmqielsat hlrsssiphl gfil
//
LOCUS       NP_001394504             464 aa            linear   ROD 09-OCT-2023
DEFINITION  mitogen-activated protein kinase 10 isoform 1 [Mus musculus].
ACCESSION   NP_001394504
VERSION     NP_001394504.1
DBSOURCE    REFSEQ: accession NM_001407575.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 464)
  AUTHORS   Priego M, Noriega L, Kalinin S, Hoffman LM, Feinstein DL and
            Morfini G.
  TITLE     Genetic deletion of c-Jun amino-terminal kinase 3 (JNK3) modestly
            increases disease severity in a mouse model of multiple sclerosis
  JOURNAL   J Neuroimmunol 382, 578152 (2023)
   PUBMED   37454525
  REMARK    GeneRIF: Genetic deletion of c-Jun amino-terminal kinase 3 (JNK3)
            modestly increases disease severity in a mouse model of multiple
            sclerosis.
REFERENCE   2  (residues 1 to 464)
  AUTHORS   Liu F, Deng Y, Zhao Y, Li Z, Gao J, Zhang Y, Yang X, Liu Y and Xia
            Y.
  TITLE     Time series RNA-seq analysis identifies MAPK10 as a critical gene
            in diabetes mellitus-induced atrial fibrillation in mice
  JOURNAL   J Mol Cell Cardiol 168, 70-82 (2022)
   PUBMED   35489387
  REMARK    GeneRIF: Time series RNA-seq analysis identifies MAPK10 as a
            critical gene in diabetes mellitus-induced atrial fibrillation in
            mice.
REFERENCE   3  (residues 1 to 464)
  AUTHORS   Cunningham JG, Scripter JD, Nti SA and Tucker ES.
  TITLE     Early construction of the thalamocortical axon pathway requires
            c-Jun N-terminal kinase signaling within the ventral forebrain
  JOURNAL   Dev Dyn 251 (3), 459-480 (2022)
   PUBMED   34494344
REFERENCE   4  (residues 1 to 464)
  AUTHORS   Goodwani S, Fernandez C, Acton PJ, Buggia-Prevot V, McReynolds ML,
            Ma J, Hu CH, Hamby ME, Jiang Y, Le K, Soth MJ, Jones P and Ray WJ.
  TITLE     Dual Leucine Zipper Kinase Is Constitutively Active in the Adult
            Mouse Brain and Has Both Stress-Induced and Homeostatic Functions
  JOURNAL   Int J Mol Sci 21 (14), 4849 (2020)
   PUBMED   32659913
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 464)
  AUTHORS   Loughran G, Chou MY, Ivanov IP, Jungreis I, Kellis M, Kiran AM,
            Baranov PV and Atkins JF.
  TITLE     Evidence of efficient stop codon readthrough in four mammalian
            genes
  JOURNAL   Nucleic Acids Res 42 (14), 8928-8938 (2014)
   PUBMED   25013167
REFERENCE   6  (residues 1 to 464)
  AUTHORS   Beier H and Grimm M.
  TITLE     Misreading of termination codons in eukaryotes by natural nonsense
            suppressor tRNAs
  JOURNAL   Nucleic Acids Res 29 (23), 4767-4782 (2001)
   PUBMED   11726686
  REMARK    Review article
REFERENCE   7  (residues 1 to 464)
  AUTHORS   Yang DD, Kuan CY, Whitmarsh AJ, Rincon M, Zheng TS, Davis RJ, Rakic
            P and Flavell RA.
  TITLE     Absence of excitotoxicity-induced apoptosis in the hippocampus of
            mice lacking the Jnk3 gene
  JOURNAL   Nature 389 (6653), 865-870 (1997)
   PUBMED   9349820
REFERENCE   8  (residues 1 to 464)
  AUTHORS   Casanova E, Garate C, Ovalle S, Calvo P and Chinchetru MA.
  TITLE     Identification of four splice variants of the mouse
            stress-activated protein kinase JNK/SAPK alpha-isoform
  JOURNAL   Neuroreport 7 (7), 1320-1324 (1996)
   PUBMED   8817558
REFERENCE   9  (residues 1 to 464)
  AUTHORS   Martin JH, Mohit AA and Miller CA.
  TITLE     Developmental expression in the mouse nervous system of the p493F12
            SAP kinase
  JOURNAL   Brain Res Mol Brain Res 35 (1-2), 47-57 (1996)
   PUBMED   8717339
REFERENCE   10 (residues 1 to 464)
  AUTHORS   Suzuki J, Yoshida S, Chen ZL, Momota Y, Kato K, Hirata A and
            Shiosaka S.
  TITLE     Ontogeny of neuropsin mRNA expression in the mouse brain
  JOURNAL   Neurosci Res 23 (4), 345-351 (1995)
   PUBMED   8602273
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC160244.11, AC123664.15,
            AC137121.9 and AC125252.7.
            
            Summary: The protein encoded by this gene is a member of the MAP
            kinase family. MAP kinases act as integration points for multiple
            biochemical signals, and thus are involved in a wide variety of
            cellular processes, such as proliferation, differentiation,
            transcription regulation and development. This kinase is
            specifically expressed in a subset of neurons in the nervous system
            and is activated by threonine and tyrosine phosphorylation.
            Targeted deletion of this gene in mice suggests that it may have a
            role in stress-induced neuronal apoptosis. Alternatively spliced
            transcript variants encoding different isoforms have been found for
            this gene. A recent study provided evidence for translational
            readthrough in this gene, and expression of an additional
            C-terminally extended isoform via the use of an alternative
            in-frame translation termination codon. [provided by RefSeq, Dec
            2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784649.134640.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN01164131,
                                           SAMN01164138 [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..464
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 49.61 cM"
     Protein         1..464
                     /product="mitogen-activated protein kinase 10 isoform 1"
                     /EC_number="2.7.11.24"
                     /note="JNK3 beta1 protein kinase; JNK3 beta2 protein
                     kinase; MAP kinase 10; MAP kinase p49 3F12; c-Jun
                     N-terminal kinase 3; stress-activated protein kinase JNK3;
                     SAPK/Erk/kinase 2"
                     /calculated_mol_wt=52387
     Region          63..398
                     /region_name="STKc_JNK"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     c-Jun N-terminal Kinase; cd07850"
                     /db_xref="CDD:270840"
     Site            order(70..76,78,91,93,110,124,146..152,154..155,189,191,
                     193..194,196,206..207,210,221,223..226,228,265)
                     /site_type="active"
                     /db_xref="CDD:270840"
     Site            order(70..76,78,91,93,124,146..152,196,206)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270840"
     Site            order(110,154,189,191,210,221,223..226,228,265)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270840"
     Site            order(150,156,165,168,197..201,361..362,364,367)
                     /site_type="other"
                     /note="KIM docking site [polypeptide binding]"
                     /db_xref="CDD:270840"
     Site            order(206..216,220..228)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270840"
     Region          221..223
                     /region_name="TXY"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61831.2)"
     Site            221
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by MAP2K7.
                     /evidence=ECO:0000250|UniProtKB:P53779; propagated from
                     UniProtKB/Swiss-Prot (Q61831.2)"
     Site            223
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by MAP2K4.
                     /evidence=ECO:0000250|UniProtKB:P53779; propagated from
                     UniProtKB/Swiss-Prot (Q61831.2)"
     Region          405..464
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61831.2)"
     CDS             1..464
                     /gene="Mapk10"
                     /gene_synonym="C230008H04Rik; JNK3; JNK3B1; JNK3B2;
                     p493F12; p54bSAPK; SAPK(beta); Serk2"
                     /coded_by="NM_001407575.1:521..1915"
                     /note="isoform 1 is encoded by transcript variant 10"
                     /db_xref="GeneID:26414"
                     /db_xref="MGI:MGI:1346863"
ORIGIN      
        1 mslhflyycs eptldvkiaf cqgfdkhvdv ssiakhynms kskvdnqfys vevgdstftv
       61 lkryqnlkpi gsgaqgivca aydavldrnv aikklsrpfq nqthakrayr elvlmkcvnh
      121 kniisllnvf tpqktleefq dvylvmelmd anlcqviqme ldhermsyll yqmlcgikhl
      181 hsagiihrdl kpsnivvksd ctlkildfgl artagtsfmm tpyvvtryyr apevilgmgy
      241 kenvdiwsvg cimgemvrhk ilfpgrdyid qwnkvieqlg tpcpefmkkl qptvrnyven
      301 rpkyagltfp klfpdslfpa dsehnklkas qardllskml vidpakrisv ddalqhpyin
      361 vwydpaevea pppqiydkql derehtieew keliykevmn seektkngvv kgqpspsgaa
      421 vnsseslpps ssvndissms tdqtlasdtd ssleasagpl gccr
//
LOCUS       NP_001342177              73 aa            linear   ROD 09-OCT-2023
DEFINITION  SWI/SNF-related matrix-associated actin-dependent regulator of
            chromatin subfamily A containing DEAD/H box 1 isoform 3 [Mus
            musculus].
ACCESSION   NP_001342177
VERSION     NP_001342177.1
DBSOURCE    REFSEQ: accession NM_001355248.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 73)
  AUTHORS   Sachs P, Bergmaier P, Treutwein K and Mermoud JE.
  TITLE     The Conserved Chromatin Remodeler SMARCAD1 Interacts with TFIIIC
            and Architectural Proteins in Human and Mouse
  JOURNAL   Genes (Basel) 14 (9), 1793 (2023)
   PUBMED   37761933
  REMARK    GeneRIF: The Conserved Chromatin Remodeler SMARCAD1 Interacts with
            TFIIIC and Architectural Proteins in Human and Mouse.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 73)
  AUTHORS   Bedogni F and Hevner RF.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 73)
  AUTHORS   Niu Q, Wang W, Wei Z, Byeon B, Das AB, Chen BS and Wu WH.
  TITLE     Role of the ATP-dependent chromatin remodeling enzyme
            Fun30/Smarcad1 in the regulation of mRNA splicing
  JOURNAL   Biochem Biophys Res Commun 526 (2), 453-458 (2020)
   PUBMED   32234239
  REMARK    GeneRIF: Role of the ATP-dependent chromatin remodeling enzyme
            Fun30/Smarcad1 in the regulation of mRNA splicing.
REFERENCE   4  (residues 1 to 73)
  AUTHORS   Kazakevych J, Denizot J, Liebert A, Portovedo M, Mosavie M, Jain P,
            Stellato C, Fraser C, Correa RO, Celestine M, Mattiuz R, Okkenhaug
            H, Miller JR, Vinolo MAR, Veldhoen M and Varga-Weisz P.
  TITLE     Smarcad1 mediates microbiota-induced inflammation in mouse and
            coordinates gene expression in the intestinal epithelium
  JOURNAL   Genome Biol 21 (1), 64 (2020)
   PUBMED   32160911
  REMARK    GeneRIF: Smarcad1 mediates microbiota-induced inflammation in mouse
            and coordinates gene expression in the intestinal epithelium.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 73)
  AUTHORS   Sachs P, Ding D, Bergmaier P, Lamp B, Schlagheck C, Finkernagel F,
            Nist A, Stiewe T and Mermoud JE.
  TITLE     SMARCAD1 ATPase activity is required to silence endogenous
            retroviruses in embryonic stem cells
  JOURNAL   Nat Commun 10 (1), 1335 (2019)
   PUBMED   30902974
  REMARK    GeneRIF: These findings uncover a role for the enzymatic activity
            of SMARCAD1 in cooperating with KAP1 to silence Endogenous
            retroviruses.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 73)
  AUTHORS   Ben-Arie N, McCall AE, Berkman S, Eichele G, Bellen HJ and Zoghbi
            HY.
  TITLE     Evolutionary conservation of sequence and expression of the bHLH
            protein Atonal suggests a conserved role in neurogenesis
  JOURNAL   Hum Mol Genet 5 (9), 1207-1216 (1996)
   PUBMED   8872459
REFERENCE   7  (residues 1 to 73)
  AUTHORS   Villeneuve L, Jiang X, Turmel C, Kozak CA and Jolicoeur P.
  TITLE     Long-range mapping of Mis-2, a common provirus integration site
            identified in murine leukemia virus-induced thymomas and located
            160 kilobase pairs downstream of Myb
  JOURNAL   J Virol 67 (10), 5733-5739 (1993)
   PUBMED   8371338
REFERENCE   8  (residues 1 to 73)
  AUTHORS   Schoor M, Schuster-Gossler K and Gossler A.
  TITLE     The Etl-1 gene encodes a nuclear protein differentially expressed
            during early mouse development
  JOURNAL   Dev Dyn 197 (3), 227-237 (1993)
   PUBMED   8219362
REFERENCE   9  (residues 1 to 73)
  AUTHORS   Soininen R, Schoor M, Henseling U, Tepe C, Kisters-Woike B, Rossant
            J and Gossler A.
  TITLE     The mouse Enhancer trap locus 1 (Etl-1): a novel mammalian gene
            related to Drosophila and yeast transcriptional regulator genes
  JOURNAL   Mech Dev 39 (1-2), 111-123 (1992)
   PUBMED   1489724
REFERENCE   10 (residues 1 to 73)
  AUTHORS   O'Kane CJ and Gehring WJ.
  TITLE     Detection in situ of genomic regulatory elements in Drosophila
  JOURNAL   Proc Natl Acad Sci U S A 84 (24), 9123-9127 (1987)
   PUBMED   2827169
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC138622.4.
            
            Transcript Variant: This variant (3) lacks several exons and
            includes an alternate 3' terminal exon, compared to variant 1. The
            encoded protein (isoform 3) is shorter and has a distinct
            C-terminus, compared to isoform 1. Variants 3, 4, and 7 all encode
            the same protein (isoform 3).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CA979535.1, AK011724.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..73
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 30.11 cM"
     Protein         1..73
                     /product="SWI/SNF-related matrix-associated
                     actin-dependent regulator of chromatin subfamily A
                     containing DEAD/H box 1 isoform 3"
                     /EC_number="3.6.4.12"
                     /note="enhancer trap locus homolog 1; ATP-dependent
                     helicase SMARCAD1; enhancer trap locus 1"
                     /calculated_mol_wt=7806
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:Q9H4L7; propagated from
                     UniProtKB/Swiss-Prot (Q04692.2)"
     Site            54
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9H4L7; propagated from
                     UniProtKB/Swiss-Prot (Q04692.2)"
     Site            57
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H4L7; propagated from
                     UniProtKB/Swiss-Prot (Q04692.2)"
     CDS             1..73
                     /gene="Smarcad1"
                     /gene_synonym="D6Pas1; etl-1; Etl1; mKIAA1122"
                     /coded_by="NM_001355248.2:192..413"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS90055.1"
                     /db_xref="GeneID:13990"
                     /db_xref="MGI:MGI:95453"
ORIGIN      
        1 mnlfnldrfr fekrskieea peaapqpsqa rpsspislsa eeenaegegs rantpdsdvt
       61 ektgsdfval alv
//
LOCUS       NP_001346926             656 aa            linear   ROD 09-OCT-2023
DEFINITION  receptor-interacting serine/threonine-protein kinase 1 [Mus
            musculus].
ACCESSION   NP_001346926 XP_006516670
VERSION     NP_001346926.1
DBSOURCE    REFSEQ: accession NM_001359997.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 656)
  AUTHORS   Lu Y, Leng Y, Li Y, Wang J, Wang W, Wang R, Liu Y, Tan Q, Yang W,
            Jiang Y, Cai J, Yuan H, Weng L and Xu Q.
  TITLE     Endothelial RIPK1 protects artery bypass graft against
            arteriosclerosis by regulating SMC growth
  JOURNAL   Sci Adv 9 (35), eadh8939 (2023)
   PUBMED   37647392
  REMARK    GeneRIF: Endothelial RIPK1 protects artery bypass graft against
            arteriosclerosis by regulating SMC growth.
REFERENCE   2  (residues 1 to 656)
  AUTHORS   Sharma BR, Karki R, Rajesh Y and Kanneganti TD.
  TITLE     Immune regulator IRF1 contributes to ZBP1-, AIM2-, RIPK1-, and
            NLRP12-PANoptosome activation and inflammatory cell death
            (PANoptosis)
  JOURNAL   J Biol Chem 299 (9), 105141 (2023)
   PUBMED   37557956
  REMARK    GeneRIF: Immune regulator IRF1 contributes to ZBP1-, AIM2-, RIPK1-,
            and NLRP12-PANoptosome activation and inflammatory cell death
            (PANoptosis).
REFERENCE   3  (residues 1 to 656)
  AUTHORS   Vucur M, Ghallab A, Schneider AT, Adili A, Cheng M, Castoldi M,
            Singer MT, Buttner V, Keysberg LS, Kusgens L, Kohlhepp M, Gorg B,
            Gallage S, Barragan Avila JE, Unger K, Kordes C, Leblond AL,
            Albrecht W, Loosen SH, Lohr C, Jordens MS, Babler A, Hayat S,
            Schumacher D, Koenen MT, Govaere O, Boekschoten MV, Jors S,
            Villacorta-Martin C, Mazzaferro V, Llovet JM, Weiskirchen R, Kather
            JN, Starlinger P, Trauner M, Luedde M, Heij LR, Neumann UP, Keitel
            V, Bode JG, Schneider RK, Tacke F, Levkau B, Lammers T, Fluegen G,
            Alexandrov T, Collins AL, Nelson G, Oakley F, Mann DA, Roderburg C,
            Longerich T, Weber A, Villanueva A, Samson AL, Murphy JM, Kramann
            R, Geisler F, Costa IG, Hengstler JG, Heikenwalder M and Luedde T.
  TITLE     Sublethal necroptosis signaling promotes inflammation and liver
            cancer
  JOURNAL   Immunity 56 (7), 1578-1595 (2023)
   PUBMED   37329888
REFERENCE   4  (residues 1 to 656)
  AUTHORS   Zhang T, Xu D, Trefts E, Lv M, Inuzuka H, Song G, Liu M, Lu J, Liu
            J, Chu C, Wang M, Wang H, Meng H, Liu H, Zhuang Y, Xie X, Dang F,
            Guan D, Men Y, Jiang S, Jiang C, Dai X, Liu J, Wang Z, Yan P, Wang
            J, Tu Z, Babuta M, Erickson E, Hillis AL, Dibble CC, Asara JM,
            Szabo G, Sicinski P, Miao J, Lee YR, Pan L, Shaw RJ, Yuan J and Wei
            W.
  TITLE     Metabolic orchestration of cell death by AMPK-mediated
            phosphorylation of RIPK1
  JOURNAL   Science 380 (6652), 1372-1380 (2023)
   PUBMED   37384704
  REMARK    GeneRIF: Metabolic orchestration of cell death by AMPK-mediated
            phosphorylation of RIPK1.
REFERENCE   5  (residues 1 to 656)
  AUTHORS   Carty F, Layzell S, Barbarulo A, Islam F, Webb LV and Seddon B.
  TITLE     IKK promotes naive T cell survival by repressing RIPK1-dependent
            apoptosis and activating NF-kappaB
  JOURNAL   Sci Signal 16 (791), eabo4094 (2023)
   PUBMED   37368952
  REMARK    GeneRIF: IKK promotes naive T cell survival by repressing
            RIPK1-dependent apoptosis and activating NF-kappaB.
REFERENCE   6  (residues 1 to 656)
  AUTHORS   Kaiserman D, Knaggs S, Scarff KL, Gillard A, Mirza G, Cadman M,
            McKeone R, Denny P, Cooley J, Benarafa C, Remold-O'Donnell E,
            Ragoussis J and Bird PI.
  TITLE     Comparison of human chromosome 6p25 with mouse chromosome 13
            reveals a greatly expanded ov-serpin gene repertoire in the mouse
  JOURNAL   Genomics 79 (3), 349-362 (2002)
   PUBMED   11863365
REFERENCE   7  (residues 1 to 656)
  AUTHORS   Melnick M, Chen H, Zhou Y and Jaskoll T.
  TITLE     Embryonic mouse submandibular salivary gland morphogenesis and the
            TNF/TNF-R1 signal transduction pathway
  JOURNAL   Anat Rec 262 (3), 318-330 (2001)
   PUBMED   11241200
REFERENCE   8  (residues 1 to 656)
  AUTHORS   Hofmann K.
  TITLE     The modular nature of apoptotic signaling proteins
  JOURNAL   Cell Mol Life Sci 55 (8-9), 1113-1128 (1999)
   PUBMED   10442092
  REMARK    Review article
REFERENCE   9  (residues 1 to 656)
  AUTHORS   Kelliher MA, Grimm S, Ishida Y, Kuo F, Stanger BZ and Leder P.
  TITLE     The death domain kinase RIP mediates the TNF-induced NF-kappaB
            signal
  JOURNAL   Immunity 8 (3), 297-303 (1998)
   PUBMED   9529147
REFERENCE   10 (residues 1 to 656)
  AUTHORS   Stanger BZ, Leder P, Lee TH, Kim E and Seed B.
  TITLE     RIP: a novel protein containing a death domain that interacts with
            Fas/APO-1 (CD95) in yeast and causes cell death
  JOURNAL   Cell 81 (4), 513-523 (1995)
   PUBMED   7538908
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161117.4.
            
            On Jan 24, 2018 this sequence version replaced XP_006516670.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156803.1, BC058162.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..656
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 14.01 cM"
     Protein         1..656
                     /product="receptor-interacting serine/threonine-protein
                     kinase 1"
                     /EC_number="2.7.11.1"
                     /note="cell death protein RIP; receptor-interacting
                     protein 1; serine/threonine-protein kinase RIP"
                     /calculated_mol_wt=74724
     Site            6
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by IKKA and IKKB.
                     /evidence=ECO:0000269|PubMed:30988283; propagated from
                     UniProtKB/Swiss-Prot (Q60855.1)"
     Region          23..291
                     /region_name="PKc_like"
                     /note="Protein Kinases, catalytic domain; cl21453"
                     /db_xref="CDD:451246"
     Site            order(23..26,29,31,43,45,76,92..95,138,142..143,145,
                     155..156)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270870"
     Site            25
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by IKKA and IKKB.
                     /evidence=ECO:0000269|PubMed:30988283; propagated from
                     UniProtKB/Swiss-Prot (Q60855.1)"
     Site            161
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by RIPK3 and autocatalysis.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q60855.1)"
     Site            166
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by autocatalysis.
                     /evidence=ECO:0000269|PubMed:27819682,
                     ECO:0000269|PubMed:28701375, ECO:0000269|PubMed:29440439,
                     ECO:0000269|PubMed:30988283, ECO:0000269|PubMed:31519886,
                     ECO:0000269|PubMed:31519887; propagated from
                     UniProtKB/Swiss-Prot (Q60855.1)"
     Site            169
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000269|PubMed:30988283; propagated from
                     UniProtKB/Swiss-Prot (Q60855.1)"
     Region          291..567
                     /region_name="Interaction with SQSTM1.
                     /evidence=ECO:0000250|UniProtKB:Q13546"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60855.1)"
     Site            304
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13546; propagated from
                     UniProtKB/Swiss-Prot (Q60855.1)"
     Site            313
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q60855.1)"
     Site            321
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by MAP3K7.
                     /evidence=ECO:0000269|PubMed:28842570,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q60855.1)"
     Site            325..326
                     /site_type="cleavage"
                     /note="Cleavage, by CASP8.
                     /evidence=ECO:0000269|PubMed:31511692,
                     ECO:0000269|PubMed:31827280, ECO:0000269|PubMed:31827281;
                     propagated from UniProtKB/Swiss-Prot (Q60855.1)"
     Region          327..373
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60855.1)"
     Site            332
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by MAP3K7.
                     /evidence=ECO:0000269|PubMed:28842570; propagated from
                     UniProtKB/Swiss-Prot (Q60855.1)"
     Site            334
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by MAP3K7.
                     /evidence=ECO:0000269|PubMed:28842570; propagated from
                     UniProtKB/Swiss-Prot (Q60855.1)"
     Site            383
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q13546; propagated from
                     UniProtKB/Swiss-Prot (Q60855.1)"
     Region          388..423
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60855.1)"
     Region          520..536
                     /region_name="RIP homotypic interaction motif (RHIM).
                     /evidence=ECO:0000269|PubMed:18442983,
                     ECO:0000269|PubMed:27819681, ECO:0000269|PubMed:27819682"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60855.1)"
     Region          568..653
                     /region_name="Death_RIP1"
                     /note="Death Domain of Receptor-Interacting Protein 1;
                     cd08777"
                     /db_xref="CDD:260048"
     CDS             1..656
                     /gene="Ripk1"
                     /gene_synonym="D330015H01Rik; Rinp; RIP; RIP-1; Rip1"
                     /coded_by="NM_001359997.1:401..2371"
                     /db_xref="CCDS:CCDS26443.1"
                     /db_xref="GeneID:19766"
                     /db_xref="MGI:MGI:108212"
ORIGIN      
        1 mqpdmsldni kmassdllek tdldsggfgk vslcyhrshg fvilkkvytg pnraeynevl
       61 leegkmmhrl rhsrvvkllg iiieegnysl vmeymekgnl mhvlktqidv plslkgriiv
      121 eaiegmcylh dkgvihkdlk penilvdrdf hikiadlgva sfktwskltk ekdnkqkevs
      181 sttkknnggt lyymapehln dinakpteks dvysfgivlw aifakkepye nvicteqfvi
      241 ciksgnrpnv eeileycpre iislmercwq aipedrptfl gieeefrpfy lshfeeyvee
      301 dvaslkkeyp dqspvlqrmf slqhdcvplp psrsnseqpg slhssqglqm gpveeswfss
      361 speypqdend rsvqaklqee asyhafgifa ekqtkpqprq neaynreeer krrvshdpfa
      421 qqrareniks agarghsdps ttsrgiavqq lswpatqtvw nnglynqhgf gttgtgvwyp
      481 pnlsqmysty ktpvpetnip gstptmpyfs gpvaddliky tifnssgiqi gnhnymdvgl
      541 nsqppnntck eestsrhqai fdnttsltde hlnpirenlg rqwkncarkl gftesqidei
      601 dhdyerdglk ekvyqmlqkw lmregtkgat vgklaqalhq ccridllnhl irasqs
//
LOCUS       NP_001394515             402 aa            linear   ROD 09-OCT-2023
DEFINITION  mitogen-activated protein kinase 10 isoform 9 [Mus musculus].
ACCESSION   NP_001394515
VERSION     NP_001394515.1
DBSOURCE    REFSEQ: accession NM_001407586.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 402)
  AUTHORS   Priego M, Noriega L, Kalinin S, Hoffman LM, Feinstein DL and
            Morfini G.
  TITLE     Genetic deletion of c-Jun amino-terminal kinase 3 (JNK3) modestly
            increases disease severity in a mouse model of multiple sclerosis
  JOURNAL   J Neuroimmunol 382, 578152 (2023)
   PUBMED   37454525
  REMARK    GeneRIF: Genetic deletion of c-Jun amino-terminal kinase 3 (JNK3)
            modestly increases disease severity in a mouse model of multiple
            sclerosis.
REFERENCE   2  (residues 1 to 402)
  AUTHORS   Liu F, Deng Y, Zhao Y, Li Z, Gao J, Zhang Y, Yang X, Liu Y and Xia
            Y.
  TITLE     Time series RNA-seq analysis identifies MAPK10 as a critical gene
            in diabetes mellitus-induced atrial fibrillation in mice
  JOURNAL   J Mol Cell Cardiol 168, 70-82 (2022)
   PUBMED   35489387
  REMARK    GeneRIF: Time series RNA-seq analysis identifies MAPK10 as a
            critical gene in diabetes mellitus-induced atrial fibrillation in
            mice.
REFERENCE   3  (residues 1 to 402)
  AUTHORS   Cunningham JG, Scripter JD, Nti SA and Tucker ES.
  TITLE     Early construction of the thalamocortical axon pathway requires
            c-Jun N-terminal kinase signaling within the ventral forebrain
  JOURNAL   Dev Dyn 251 (3), 459-480 (2022)
   PUBMED   34494344
REFERENCE   4  (residues 1 to 402)
  AUTHORS   Goodwani S, Fernandez C, Acton PJ, Buggia-Prevot V, McReynolds ML,
            Ma J, Hu CH, Hamby ME, Jiang Y, Le K, Soth MJ, Jones P and Ray WJ.
  TITLE     Dual Leucine Zipper Kinase Is Constitutively Active in the Adult
            Mouse Brain and Has Both Stress-Induced and Homeostatic Functions
  JOURNAL   Int J Mol Sci 21 (14), 4849 (2020)
   PUBMED   32659913
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 402)
  AUTHORS   Loughran G, Chou MY, Ivanov IP, Jungreis I, Kellis M, Kiran AM,
            Baranov PV and Atkins JF.
  TITLE     Evidence of efficient stop codon readthrough in four mammalian
            genes
  JOURNAL   Nucleic Acids Res 42 (14), 8928-8938 (2014)
   PUBMED   25013167
REFERENCE   6  (residues 1 to 402)
  AUTHORS   Beier H and Grimm M.
  TITLE     Misreading of termination codons in eukaryotes by natural nonsense
            suppressor tRNAs
  JOURNAL   Nucleic Acids Res 29 (23), 4767-4782 (2001)
   PUBMED   11726686
  REMARK    Review article
REFERENCE   7  (residues 1 to 402)
  AUTHORS   Yang DD, Kuan CY, Whitmarsh AJ, Rincon M, Zheng TS, Davis RJ, Rakic
            P and Flavell RA.
  TITLE     Absence of excitotoxicity-induced apoptosis in the hippocampus of
            mice lacking the Jnk3 gene
  JOURNAL   Nature 389 (6653), 865-870 (1997)
   PUBMED   9349820
REFERENCE   8  (residues 1 to 402)
  AUTHORS   Casanova E, Garate C, Ovalle S, Calvo P and Chinchetru MA.
  TITLE     Identification of four splice variants of the mouse
            stress-activated protein kinase JNK/SAPK alpha-isoform
  JOURNAL   Neuroreport 7 (7), 1320-1324 (1996)
   PUBMED   8817558
REFERENCE   9  (residues 1 to 402)
  AUTHORS   Martin JH, Mohit AA and Miller CA.
  TITLE     Developmental expression in the mouse nervous system of the p493F12
            SAP kinase
  JOURNAL   Brain Res Mol Brain Res 35 (1-2), 47-57 (1996)
   PUBMED   8717339
REFERENCE   10 (residues 1 to 402)
  AUTHORS   Suzuki J, Yoshida S, Chen ZL, Momota Y, Kato K, Hirata A and
            Shiosaka S.
  TITLE     Ontogeny of neuropsin mRNA expression in the mouse brain
  JOURNAL   Neurosci Res 23 (4), 345-351 (1995)
   PUBMED   8602273
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC160244.11, AC123664.15,
            AC137121.9 and AC125252.7.
            
            Summary: The protein encoded by this gene is a member of the MAP
            kinase family. MAP kinases act as integration points for multiple
            biochemical signals, and thus are involved in a wide variety of
            cellular processes, such as proliferation, differentiation,
            transcription regulation and development. This kinase is
            specifically expressed in a subset of neurons in the nervous system
            and is activated by threonine and tyrosine phosphorylation.
            Targeted deletion of this gene in mice suggests that it may have a
            role in stress-induced neuronal apoptosis. Alternatively spliced
            transcript variants encoding different isoforms have been found for
            this gene. A recent study provided evidence for translational
            readthrough in this gene, and expression of an additional
            C-terminally extended isoform via the use of an alternative
            in-frame translation termination codon. [provided by RefSeq, Dec
            2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784649.385457.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..402
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 49.61 cM"
     Protein         1..402
                     /product="mitogen-activated protein kinase 10 isoform 9"
                     /EC_number="2.7.11.24"
                     /note="JNK3 beta1 protein kinase; JNK3 beta2 protein
                     kinase; MAP kinase 10; MAP kinase p49 3F12; c-Jun
                     N-terminal kinase 3; stress-activated protein kinase JNK3;
                     SAPK/Erk/kinase 2"
                     /calculated_mol_wt=45208
     Region          25..336
                     /region_name="STKc_JNK"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     c-Jun N-terminal Kinase; cd07850"
                     /db_xref="CDD:270840"
     Site            order(32..38,40,53,55,72,86,108..114,116..117,151,153,
                     155..156,158,168..169,172,183,185..188,190)
                     /site_type="active"
                     /db_xref="CDD:270840"
     Site            order(32..38,40,53,55,86,108..114,158,168)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270840"
     Site            order(72,116,151,153,172,183,185..188,190)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270840"
     Site            order(112,118,127,130,159..163,299..300,302,305)
                     /site_type="other"
                     /note="KIM docking site [polypeptide binding]"
                     /db_xref="CDD:270840"
     Site            order(168..178,182..190)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270840"
     CDS             1..402
                     /gene="Mapk10"
                     /gene_synonym="C230008H04Rik; JNK3; JNK3B1; JNK3B2;
                     p493F12; p54bSAPK; SAPK(beta); Serk2"
                     /coded_by="NM_001407586.1:658..1866"
                     /note="isoform 9 is encoded by transcript variant 17"
                     /db_xref="GeneID:26414"
                     /db_xref="MGI:MGI:1346863"
ORIGIN      
        1 mskskvdnqf ysvevgdstf tvlkryqnlk pigsgaqgiv caaydavldr nvaikklsrp
       61 fqnqthakra yrelvlmkcv nhkniislln vftpqktlee fqdvylvmel mdanlcqviq
      121 meldhermsy llyqmlcgik hlhsagiihr dlkpsnivvk sdctlkildf glartagtsf
      181 mmtpyvvtry yrapevilgm gykendidqw nkvieqlgtp cpefmkklqp tvrnyvenrp
      241 kyagltfpkl fpdslfpads ehnklkasqa rdllskmlvi dpakrisvdd alqhpyinvw
      301 ydpaeveapp pqiydkqlde rehtieewke liykevmnse ektkngvvkg qpspsgaavn
      361 sseslppsss vndissmstd qtlasdtdss leasagplgc cr
//
LOCUS       NP_001397180             430 aa            linear   ROD 09-OCT-2023
DEFINITION  Friend leukemia integration 1 transcription factor isoform 2 [Mus
            musculus].
ACCESSION   NP_001397180 XP_036010504
VERSION     NP_001397180.1
DBSOURCE    REFSEQ: accession NM_001410251.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 430)
  AUTHORS   Wang X, Richard ML, Caldwell TS, Sundararaj K, Sato S, Nowling TK
            and Zhang XK.
  TITLE     Role of the transcription factor Fli-1 on the CXCL10/CXCR3 Axis
  JOURNAL   Front Immunol 14, 1219279 (2023)
   PUBMED   37790939
  REMARK    GeneRIF: Role of the transcription factor Fli-1 on the CXCL10/CXCR3
            Axis.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 430)
  AUTHORS   Sato S, Zhang XK, Matsuoka N, Sumichika Y, Saito K, Yoshida S,
            Matsumoto H, Temmoku J, Fujita Y, Asano T and Migita K.
  TITLE     Transcription factor Fli-1 impacts the expression of CXCL13 and
            regulates immune cell infiltration into the kidney in MRL/lpr mouse
  JOURNAL   Lupus Sci Med 10 (1) (2023)
   PUBMED   37094946
  REMARK    GeneRIF: Transcription factor Fli-1 impacts the expression of
            CXCL13 and regulates immune cell infiltration into the kidney in
            MRL/lpr mouse.
REFERENCE   3  (residues 1 to 430)
  AUTHORS   Shintani A, Fukai S, Nobusawa R, Taniguchi K, Hatatani T, Nagai H,
            Sakai T, Yoshimura T, Miyasaka M and Hayasaka H.
  TITLE     Dach1 transcription factor regulates the expression of peripheral
            node addressin and lymphocyte trafficking in lymph nodes
  JOURNAL   Curr Res Immunol 3, 175-185 (2022)
   PUBMED   36045707
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 430)
  AUTHORS   Sinha T, Lammerts van Bueren K, Dickel DE, Zlatanova I, Thomas R,
            Lizama CO, Xu SM, Zovein AC, Ikegami K, Moskowitz IP, Pollard KS,
            Pennacchio LA and Black BL.
  TITLE     Differential Etv2 threshold requirement for endothelial and
            erythropoietic development
  JOURNAL   Cell Rep 39 (9), 110881 (2022)
   PUBMED   35649376
REFERENCE   5  (residues 1 to 430)
  AUTHORS   Sarrazin S, Starck J, Gonnet C, Doubeikovski A, Melet F and Morle
            F.
  TITLE     Negative and translation termination-dependent positive control of
            FLI-1 protein synthesis by conserved overlapping 5' upstream open
            reading frames in Fli-1 mRNA
  JOURNAL   Mol Cell Biol 20 (9), 2959-2969 (2000)
   PUBMED   10757781
REFERENCE   6  (residues 1 to 430)
  AUTHORS   Barbeau B, Bergeron D, Beaulieu M, Nadjem Z and Rassart E.
  TITLE     Characterization of the human and mouse Fli-1 promoter regions
  JOURNAL   Biochim Biophys Acta 1307 (2), 220-232 (1996)
   PUBMED   8679708
REFERENCE   7  (residues 1 to 430)
  AUTHORS   Watson DK, Smyth FE, Thompson DM, Cheng JQ, Testa JR, Papas TS and
            Seth A.
  TITLE     The ERGB/Fli-1 gene: isolation and characterization of a new member
            of the family of human ETS transcription factors
  JOURNAL   Cell Growth Differ 3 (10), 705-713 (1992)
   PUBMED   1445800
REFERENCE   8  (residues 1 to 430)
  AUTHORS   Delattre O, Zucman J, Plougastel B, Desmaze C, Melot T, Peter M,
            Kovar H, Joubert I, de Jong P, Rouleau G et al.
  TITLE     Gene fusion with an ETS DNA-binding domain caused by chromosome
            translocation in human tumours
  JOURNAL   Nature 359 (6391), 162-165 (1992)
   PUBMED   1522903
REFERENCE   9  (residues 1 to 430)
  AUTHORS   Moore SK, Appella E, Villar CJ and Kozak CA.
  TITLE     Mapping of the mouse 86-kDa heat-shock protein expressed gene
            (Hsp86-1) on chromosome 12 and related genes on chromosomes 3, 4,
            9, and 11
  JOURNAL   Genomics 10 (4), 1019-1029 (1991)
   PUBMED   1916807
REFERENCE   10 (residues 1 to 430)
  AUTHORS   Bergeron D, Poliquin L, Kozak CA and Rassart E.
  TITLE     Identification of a common viral integration region in Cas-Br-E
            murine leukemia virus-induced non-T-, non-B-cell lymphomas
  JOURNAL   J Virol 65 (1), 7-15 (1991)
   PUBMED   1845910
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127581.4 and AC141646.4.
            
            On Aug 1, 2022 this sequence version replaced XP_036010504.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.4528473.1,
                                           SRR13862101.1620945.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..430
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 17.74 cM"
     Protein         1..430
                     /product="Friend leukemia integration 1 transcription
                     factor isoform 2"
                     /note="friend leukemia integration 1 transcription factor;
                     retroviral integration site protein Fli-1"
                     /calculated_mol_wt=48436
     Region          114..199
                     /region_name="SAM_PNT-FLI-1"
                     /note="Sterile alpha motif (SAM)/Pointed domain of friend
                     leukemia integration 1 transcription activator; cd08541"
                     /db_xref="CDD:188883"
     Region          258..341
                     /region_name="ETS"
                     /note="erythroblast transformation specific domain;
                     smart00413"
                     /db_xref="CDD:197710"
     CDS             1..430
                     /gene="Fli1"
                     /gene_synonym="EWSR2; Fli-1; SIC-1; Sic1"
                     /coded_by="NM_001410251.1:190..1482"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="GeneID:14247"
                     /db_xref="MGI:MGI:95554"
ORIGIN      
        1 mdgtikeals vvsddqslfd saygaaahlp kadmtasgsp dygqphkinp lppqqewinq
       61 pvrvnvkrey dhmngsresp vdcsvskcnk lvgggeanpm nynsymdekn gppppnmttn
      121 errvivpadp tlwtqehvrq wlewaikeyg lmeidtsffq nmdgkelckm nkedflrats
      181 ayntevllsh lsylrenpsy dsvrrgawnn nmnsglnksp llggsqtmgk nteqrpqpdp
      241 yqilgptssr lanpgsgqiq lwqfllells dsanascitw egtngefkmt dpdevarrwg
      301 erkskpnmny dklsralryy ydknimtkvh gkryaykfdf hgiaqalqph ptetsmykyp
      361 sdisympsyh ahqqkvnfvp shpssmpvts ssffgaasqy wtsptagiyp npsvprhpnt
      421 hvpshlgsyy
//
LOCUS       NP_296371                309 aa            linear   ROD 09-OCT-2023
DEFINITION  tumor necrosis factor ligand superfamily member 13B isoform 1 [Mus
            musculus].
ACCESSION   NP_296371
VERSION     NP_296371.1
DBSOURCE    REFSEQ: accession NM_033622.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 309)
  AUTHORS   Doll JR, Moreno-Fernandez ME, Stankiewicz TE, Wayland JL, Wilburn
            A, Weinhaus B, Chougnet CA, Giordano D, Cappelletti M, Presicce P,
            Kallapur SG, Salomonis N, Tilburgs T and Divanovic S.
  TITLE     BAFF and APRIL counterregulate susceptibility to
            inflammation-induced preterm birth
  JOURNAL   Cell Rep 42 (4), 112352 (2023)
   PUBMED   37027297
  REMARK    GeneRIF: BAFF and APRIL counterregulate susceptibility to
            inflammation-induced preterm birth.
REFERENCE   2  (residues 1 to 309)
  AUTHORS   Giordano D, Kuley R, Draves KE, Elkon KB, Giltiay NV and Clark EA.
  TITLE     B cell-activating factor (BAFF) from dendritic cells, monocytes and
            neutrophils is required for B cell maturation and autoantibody
            production in SLE-like autoimmune disease
  JOURNAL   Front Immunol 14, 1050528 (2023)
   PUBMED   36923413
  REMARK    GeneRIF: B cell-activating factor (BAFF) from dendritic cells,
            monocytes and neutrophils is required for B cell maturation and
            autoantibody production in SLE-like autoimmune disease.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 309)
  AUTHORS   Kanemitsu-Okada K, Abe M, Nakamura Y, Miyake T, Watanabe T, Yoshida
            O, Koizumi Y, Hirooka M, Tokumoto Y, Matsuura B, Koizumi M and
            Hiasa Y.
  TITLE     Role of B Cell-Activating Factor in Fibrosis Progression in a
            Murine Model of Non-Alcoholic Steatohepatitis
  JOURNAL   Int J Mol Sci 24 (3), 2509 (2023)
   PUBMED   36768854
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 309)
  AUTHORS   Stohl W, Yu N and Wu Y.
  TITLE     B Cell and T Cell Dissimilarities in BAFF-Deficient versus
            BR3-Deficient C57BL/6 Mice
  JOURNAL   J Immunol 209 (11), 2133-2140 (2022)
   PUBMED   36426969
  REMARK    GeneRIF: B Cell and T Cell Dissimilarities in BAFF-Deficient versus
            BR3-Deficient C57BL/6 Mice.
REFERENCE   5  (residues 1 to 309)
  AUTHORS   Liu W, Stachura P, Xu HC, Varaljai R, Shinde P, Ganesh NU, Mack M,
            Van Lierop A, Huang A, Sundaram B, Lang KS, Picard D, Fischer U,
            Remke M, Homey B, Roesch A, Haussinger D, Lang PA, Borkhardt A and
            Pandyra AA.
  TITLE     BAFF Attenuates Immunosuppressive Monocytes in the Melanoma Tumor
            Microenvironment
  JOURNAL   Cancer Res 82 (2), 264-277 (2022)
   PUBMED   34810198
  REMARK    GeneRIF: BAFF Attenuates Immunosuppressive Monocytes in the
            Melanoma Tumor Microenvironment.
REFERENCE   6  (residues 1 to 309)
  AUTHORS   Yu G, Boone T, Delaney J, Hawkins N, Kelley M, Ramakrishnan M,
            McCabe S, Qiu WR, Kornuc M, Xia XZ, Guo J, Stolina M, Boyle WJ,
            Sarosi I, Hsu H, Senaldi G and Theill LE.
  TITLE     APRIL and TALL-I and receptors BCMA and TACI: system for regulating
            humoral immunity
  JOURNAL   Nat Immunol 1 (3), 252-256 (2000)
   PUBMED   10973284
REFERENCE   7  (residues 1 to 309)
  AUTHORS   Xia XZ, Treanor J, Senaldi G, Khare SD, Boone T, Kelley M, Theill
            LE, Colombero A, Solovyev I, Lee F, McCabe S, Elliott R, Miner K,
            Hawkins N, Guo J, Stolina M, Yu G, Wang J, Delaney J, Meng SY,
            Boyle WJ and Hsu H.
  TITLE     TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis
            factor family member involved in B cell regulation
  JOURNAL   J Exp Med 192 (1), 137-143 (2000)
   PUBMED   10880535
REFERENCE   8  (residues 1 to 309)
  AUTHORS   Gross JA, Johnston J, Mudri S, Enselman R, Dillon SR, Madden K, Xu
            W, Parrish-Novak J, Foster D, Lofton-Day C, Moore M, Littau A,
            Grossman A, Haugen H, Foley K, Blumberg H, Harrison K, Kindsvogel W
            and Clegg CH.
  TITLE     TACI and BCMA are receptors for a TNF homologue implicated in
            B-cell autoimmune disease
  JOURNAL   Nature 404 (6781), 995-999 (2000)
   PUBMED   10801128
REFERENCE   9  (residues 1 to 309)
  AUTHORS   Mackay F, Woodcock SA, Lawton P, Ambrose C, Baetscher M, Schneider
            P, Tschopp J and Browning JL.
  TITLE     Mice transgenic for BAFF develop lymphocytic disorders along with
            autoimmune manifestations
  JOURNAL   J Exp Med 190 (11), 1697-1710 (1999)
   PUBMED   10587360
REFERENCE   10 (residues 1 to 309)
  AUTHORS   Schneider P, MacKay F, Steiner V, Hofmann K, Bodmer JL, Holler N,
            Ambrose C, Lawton P, Bixler S, Acha-Orbea H, Valmori D, Romero P,
            Werner-Favre C, Zubler RH, Browning JL and Tschopp J.
  TITLE     BAFF, a novel ligand of the tumor necrosis factor family,
            stimulates B cell growth
  JOURNAL   J Exp Med 189 (11), 1747-1756 (1999)
   PUBMED   10359578
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF119383.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF119383.1, AF352245.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..309
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 4.55 cM"
     Protein         1..309
                     /product="tumor necrosis factor ligand superfamily member
                     13B isoform 1"
                     /note="b cell-activating factor; tumor necrosis factor
                     ligand 7a"
                     /calculated_mol_wt=34061
     Site            48..68
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU72.1)"
     Region          110..140
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU72.1)"
     Site            117
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9WU72.1)"
     Site            126..127
                     /site_type="cleavage"
                     /note="Cleavage. /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (Q9WU72.1)"
     Region          170..306
                     /region_name="TNF"
                     /note="Tumor Necrosis Factor; TNF superfamily members
                     include the cytokines: TNF (TNF-alpha), LT
                     (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL),
                     Fas ligand, and osteoprotegerin (OPG) ligand. These
                     proteins generally have an intracellular N-terminal...;
                     cd00184"
                     /db_xref="CDD:238108"
     Site            order(172,218,220,270,275,302,306)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:238108"
     Site            order(193,195,233,240,249)
                     /site_type="active"
                     /note="receptor binding sites [active]"
                     /db_xref="CDD:238108"
     Site            266
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9WU72.1)"
     CDS             1..309
                     /gene="Tnfsf13b"
                     /gene_synonym="BAFF; BLyS; D8Ertd387e; TALL-1; TALL1;
                     THANK; TNFSF20; Tnlg7a; zTNF4"
                     /coded_by="NM_033622.2:211..1140"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS22094.1"
                     /db_xref="GeneID:24099"
                     /db_xref="MGI:MGI:1344376"
ORIGIN      
        1 mdesaktlpp pclcfcsekg edmkvgydpi tpqkeegawf gicrdgrlla atlllallss
       61 sftamslyql aalqadlmnl rmelqsyrgs atpaaagape ltagvklltp aaprphnssr
      121 ghrnrrafqg peeteqdvdl sappapclpg crhsqhddng mnlrniiqdc lqliadsdtp
      181 tirkgtytfv pwllsfkrgn aleekenkiv vrqtgyffiy sqvlytdpif amghviqrkk
      241 vhvfgdelsl vtlfrciqnm pktlpnnscy sagiarleeg deiqlaipre naqisrngdd
      301 tffgalkll
//
LOCUS       NP_032293                286 aa            linear   ROD 09-OCT-2023
DEFINITION  homeobox protein Hox-B13 [Mus musculus].
ACCESSION   NP_032293
VERSION     NP_032293.1
DBSOURCE    REFSEQ: accession NM_008267.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 286)
  AUTHORS   Chen Y, Dufour CR, Han L, Li T, Xia H and Giguere V.
  TITLE     Hierarchical Phosphorylation of HOXB13 by mTOR Dictates Its
            Activity and Oncogenic Function in Prostate Cancer
  JOURNAL   Mol Cancer Res 21 (10), 1050-1063 (2023)
   PUBMED   37409967
  REMARK    GeneRIF: Hierarchical Phosphorylation of HOXB13 by mTOR Dictates
            Its Activity and Oncogenic Function in Prostate Cancer.
REFERENCE   2  (residues 1 to 286)
  AUTHORS   Li M, Tan T, Geng Y, Tao Y, Pan J, Zhang J, Xu Q, Shen H, Zuo L and
            Chen Y.
  TITLE     HOXB13 facilitates hepatocellular carcinoma progression by
            activating AKT/mTOR signaling pathway
  JOURNAL   Ann Hepatol 28 (1), 100759 (2023)
   PUBMED   36179794
  REMARK    GeneRIF: HOXB13 facilitates hepatocellular carcinoma progression by
            activating AKT/mTOR signaling pathway.
REFERENCE   3  (residues 1 to 286)
  AUTHORS   Hauswirth GM, Garside VC, Wong LSF, Bildsoe H, Manent J, Chang YC,
            Nefzger CM, Firas J, Chen J, Rossello FJ, Polo JM and McGlinn E.
  TITLE     Breaking constraint of mammalian axial formulae
  JOURNAL   Nat Commun 13 (1), 243 (2022)
   PUBMED   35017475
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 286)
  AUTHORS   Sawai A, Pfennig S, Bulajic M, Miller A, Khodadadi-Jamayran A,
            Mazzoni EO and Dasen JS.
  TITLE     PRC1 sustains the integrity of neural fate in the absence of PRC2
            function
  JOURNAL   Elife 11, e72769 (2022)
   PUBMED   34994686
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 286)
  AUTHORS   Yogosawa S, Ohkido M, Horii T, Okazaki Y, Nakayama J, Yoshida S,
            Toyokuni S, Hatada I, Morimoto M and Yoshida K.
  TITLE     Mice lacking DYRK2 exhibit congenital malformations with lung
            hypoplasia and altered Foxf1 expression gradient
  JOURNAL   Commun Biol 4 (1), 1204 (2021)
   PUBMED   34671097
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 286)
  AUTHORS   Landgren C, Beier DR, Fassler R, Heinegard D and Sommarin Y.
  TITLE     The mouse chondroadherin gene: characterization and chromosomal
            localization
  JOURNAL   Genomics 47 (1), 84-91 (1998)
   PUBMED   9465299
REFERENCE   7  (residues 1 to 286)
  AUTHORS   Shen WF, Montgomery JC, Rozenfeld S, Moskow JJ, Lawrence HJ,
            Buchberg AM and Largman C.
  TITLE     AbdB-like Hox proteins stabilize DNA binding by the Meis1
            homeodomain proteins
  JOURNAL   Mol Cell Biol 17 (11), 6448-6458 (1997)
   PUBMED   9343407
REFERENCE   8  (residues 1 to 286)
  AUTHORS   Kohda K, Matsuda Y, Ishibashi T, Tanaka K and Kasahara M.
  TITLE     Structural analysis and chromosomal localization of the mouse Psmb5
            gene coding for the constitutively expressed beta-type proteasome
            subunit
  JOURNAL   Immunogenetics 47 (1), 77-87 (1997)
   PUBMED   9382924
REFERENCE   9  (residues 1 to 286)
  AUTHORS   Kandil E, Kohda K, Ishibashi T, Tanaka K and Kasahara M.
  TITLE     PA28 subunits of the mouse proteasome: primary structures and
            chromosomal localization of the genes
  JOURNAL   Immunogenetics 46 (4), 337-344 (1997)
   PUBMED   9218537
REFERENCE   10 (residues 1 to 286)
  AUTHORS   Zeltser L, Desplan C and Heintz N.
  TITLE     Hoxb-13: a new Hox gene in a distant region of the HOXB cluster
            maintains colinearity
  JOURNAL   Development 122 (8), 2475-2484 (1996)
   PUBMED   8756292
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645478.15.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC051087.1, BQ960077.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849378, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..286
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 59.63 cM"
     Protein         1..286
                     /product="homeobox protein Hox-B13"
                     /note="homeo box B13"
                     /calculated_mol_wt=30832
     Region          12..124
                     /region_name="HoxA13_N"
                     /note="Hox protein A13 N terminal; pfam12284"
                     /db_xref="CDD:432453"
     Region          218..274
                     /region_name="HOX"
                     /note="Homeodomain; smart00389"
                     /db_xref="CDD:197696"
     Site            order(219..223,225,242,248,261,263..264,267..268,270..272,
                     274..275)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     Region          219..248
                     /region_name="Interaction with DNA.
                     /evidence=ECO:0000250|UniProtKB:Q92826"
                     /note="propagated from UniProtKB/Swiss-Prot (P70321.1)"
     Site            order(221,224,264,267..268,271)
                     /site_type="other"
                     /note="specific DNA base contacts [nucleotide binding]"
                     /db_xref="CDD:238039"
     Region          260..275
                     /region_name="Interaction with 5-mCpG DNA.
                     /evidence=ECO:0000250|UniProtKB:Q92826"
                     /note="propagated from UniProtKB/Swiss-Prot (P70321.1)"
     Region          272..275
                     /region_name="Interaction with DNA.
                     /evidence=ECO:0000250|UniProtKB:Q92826"
                     /note="propagated from UniProtKB/Swiss-Prot (P70321.1)"
     CDS             1..286
                     /gene="Hoxb13"
                     /coded_by="NM_008267.4:128..988"
                     /db_xref="CCDS:CCDS25291.1"
                     /db_xref="GeneID:15408"
                     /db_xref="MGI:MGI:107730"
ORIGIN      
        1 mepgnyatld gakdiegllg agggrnlvsh ssplashpaa ptlmptvnya pldlpgsaep
       61 pkqchpcpgv pqgaspapvp ygyfgggyys crvsrsslkp caqtaalaty psetpapgee
      121 ypsrptefaf ypgypgpyqp masyldvsvv qtlgapgepr hdsllpvdsy qpwalaggwn
      181 sqmccqgeqn ppgpfwkaaf aepsvqhppp dgcafrrgrk kripyskgql relereyaan
      241 kfitkdkrrk isaatslser qitiwfqnrr vkekkvlakv ktsttp
//
LOCUS       NP_035410                489 aa            linear   ROD 09-OCT-2023
DEFINITION  tripartite motif-containing protein 10 [Mus musculus].
ACCESSION   NP_035410
VERSION     NP_035410.2
DBSOURCE    REFSEQ: accession NM_011280.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 489)
  AUTHORS   Kong L, Sui C, Chen T, Zhang L, Zhao W, Zheng Y, Liu B, Cheng X and
            Gao C.
  TITLE     The ubiquitin E3 ligase TRIM10 promotes STING aggregation and
            activation in the Golgi apparatus
  JOURNAL   Cell Rep 42 (4), 112306 (2023)
   PUBMED   36972172
  REMARK    GeneRIF: The ubiquitin E3 ligase TRIM10 promotes STING aggregation
            and activation in the Golgi apparatus.
REFERENCE   2  (residues 1 to 489)
  AUTHORS   Yang H, Wang XX, Zhou CY, Xiao X, Tian C, Li HH, Yin CL and Wang
            HX.
  TITLE     Tripartite motif 10 regulates cardiac hypertrophy by targeting the
            PTEN/AKT pathway
  JOURNAL   J Cell Mol Med 24 (11), 6233-6241 (2020)
   PUBMED   32343488
  REMARK    GeneRIF: Tripartite motif 10 regulates cardiac hypertrophy by
            targeting the PTEN/AKT pathway.
            Erratum:[J Cell Mol Med. 2023 Jul;27(13):1915-1917. PMID: 37394903]
REFERENCE   3  (residues 1 to 489)
  AUTHORS   Blaybel R, Theoleyre O, Douablin A and Baklouti F.
  TITLE     Downregulation of the Spi-1/PU.1 oncogene induces the expression of
            TRIM10/HERF1, a key factor required for terminal erythroid cell
            differentiation and survival
  JOURNAL   Cell Res 18 (8), 834-845 (2008)
   PUBMED   18560381
  REMARK    GeneRIF: Primary Spi-1/PU.1 downregulation acts on late erythroid
            differentiation through at least two pathways, one of which
            requires TRIM10/HERF1 upregulation and parallels the
            Spi-1/PU.1-induced Fli-1 shutoff regulatory cascade.
REFERENCE   4  (residues 1 to 489)
  AUTHORS   Uchil PD, Quinlan BD, Chan WT, Luna JM and Mothes W.
  TITLE     TRIM E3 ligases interfere with early and late stages of the
            retroviral life cycle
  JOURNAL   PLoS Pathog 4 (2), e16 (2008)
   PUBMED   18248090
REFERENCE   5  (residues 1 to 489)
  AUTHORS   Takada T, Kumanovics A, Amadou C, Yoshino M, Jones EP, Athanasiou
            M, Evans GA and Fischer Lindahl K.
  TITLE     Species-specific class I gene expansions formed the telomeric 1 mb
            of the mouse major histocompatibility complex
  JOURNAL   Genome Res 13 (4), 589-600 (2003)
   PUBMED   12671000
REFERENCE   6  (residues 1 to 489)
  AUTHORS   Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L,
            Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci
            S, Pelicci PG and Ballabio A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
REFERENCE   7  (residues 1 to 489)
  AUTHORS   Harada H, Harada Y, O'Brien DP, Rice DS, Naeve CW and Downing JR.
  TITLE     HERF1, a novel hematopoiesis-specific RING finger protein, is
            required for terminal differentiation of erythroid cells
  JOURNAL   Mol Cell Biol 19 (5), 3808-3815 (1999)
   PUBMED   10207104
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY712181.1, AK011082.1 and AI324236.1.
            
            On Aug 4, 2009 this sequence version replaced NP_035410.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK011082.1, BC051632.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849388, SAMN00849390
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 19.16 cM"
     Protein         1..489
                     /product="tripartite motif-containing protein 10"
                     /note="ring finger protein 9; tripartite motif protein 10;
                     hematopoietic RING finger 1"
                     /calculated_mol_wt=55499
     Region          9..69
                     /region_name="RING_Ubox"
                     /note="RING finger (Really Interesting New Gene) domain
                     and U-box domain superfamily; cl17238"
                     /db_xref="CDD:450175"
     Site            order(16,19,31,33,36,39,57,60)
                     /site_type="other"
                     /note="cross-brace motif"
                     /db_xref="CDD:438111"
     Region          99..135
                     /region_name="Bbox_SF"
                     /note="B-box-type zinc finger superfamily; cl00034"
                     /db_xref="CDD:444664"
     Region          309..480
                     /region_name="SPRY_PRY_TRIM10"
                     /note="PRY/SPRY domain of tripartite motif-binding protein
                     10 (TRIM10) also known as hematopoietic RING finger 1
                     (HERF1); cd15827"
                     /db_xref="CDD:293999"
     CDS             1..489
                     /gene="Trim10"
                     /gene_synonym="Herf1; Rnf9"
                     /coded_by="NM_011280.2:306..1775"
                     /db_xref="CCDS:CCDS37614.1"
                     /db_xref="GeneID:19824"
                     /db_xref="MGI:MGI:1338757"
ORIGIN      
        1 masapsvtsl adevncpicq gtlrepvtid cghnfcrgcl tryceipgpe seeslscplc
       61 kepfrpgsfr pnwqlanvve nierlqlast rglevedacp ehgekiyffc eedeaqlcvv
      121 cretgqhgah tvrfledaag pyreqiqkcl vclrkereei qetqsrenkr iqvlltqvat
      181 krqqvisqfa hlsqflqqqq tallaqlegl dgdilkqqee fdslatgeic rfstlieele
      241 eknkrtargl ltdirstlir cetrkcrkpe aispelgqri rdfpqqaipl rqemktflek
      301 lcfeldyepa hisldpqtsh pklllsedhr rarfsykwqn spdtpqrfdr vtcvlaqcgf
      361 tggrhtwmvn vdlahggsct vgvvredvrr kgelrlrpee giwavrlawg fvsalgsfpt
      421 rlaleeqprk vqvsldyevg witfvnavtq ehiytftasf tqkifplfgl wgrgssfsls
      481 cqegavsll
//
LOCUS       NP_001390655             735 aa            linear   ROD 09-OCT-2023
DEFINITION  transcriptional repressor CTCF isoform 2 [Mus musculus].
ACCESSION   NP_001390655
VERSION     NP_001390655.1
DBSOURCE    REFSEQ: accession NM_001403726.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 735)
  AUTHORS   Hewitt SC, Gruzdev A, Willson CJ, Wu SP, Lydon JP, Galjart N and
            DeMayo FJ.
  TITLE     Chromatin architectural factor CTCF is essential for
            progesterone-dependent uterine maturation
  JOURNAL   FASEB J 37 (8), e23103 (2023)
   PUBMED   37489832
  REMARK    GeneRIF: Chromatin architectural factor CTCF is essential for
            progesterone-dependent uterine maturation.
REFERENCE   2  (residues 1 to 735)
  AUTHORS   Smits WK, Vermeulen C, Hagelaar R, Kimura S, Vroegindeweij EM,
            Buijs-Gladdines JGCAM, van de Geer E, Verstegen MJAM, Splinter E,
            van Reijmersdal SV, Buijs A, Galjart N, van Eyndhoven W, van Min M,
            Kuiper R, Kemmeren P, Mullighan CG, de Laat W and Meijerink JPP.
  TITLE     Elevated enhancer-oncogene contacts and higher oncogene expression
            levels by recurrent CTCF inactivating mutations in acute T cell
            leukemia
  JOURNAL   Cell Rep 42 (4), 112373 (2023)
   PUBMED   37060567
REFERENCE   3  (residues 1 to 735)
  AUTHORS   Wang B, Ji L and Bian Q.
  TITLE     SATB1 regulates 3D genome architecture in T cells by constraining
            chromatin interactions surrounding CTCF-binding sites
  JOURNAL   Cell Rep 42 (4), 112323 (2023)
   PUBMED   37000624
  REMARK    GeneRIF: SATB1 regulates 3D genome architecture in T cells by
            constraining chromatin interactions surrounding CTCF-binding sites.
REFERENCE   4  (residues 1 to 735)
  AUTHORS   Marina-Zarate E, Rodriguez-Ronchel A, Gomez MJ, Sanchez-Cabo F and
            Ramiro AR.
  TITLE     Low-affinity CTCF binding drives transcriptional regulation whereas
            high-affinity binding encompasses architectural functions
  JOURNAL   iScience 26 (3), 106106 (2023)
   PUBMED   36852270
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 735)
  AUTHORS   Hsieh TS, Cattoglio C, Slobodyanyuk E, Hansen AS, Darzacq X and
            Tjian R.
  TITLE     Enhancer-promoter interactions and transcription are largely
            maintained upon acute loss of CTCF, cohesin, WAPL or YY1
  JOURNAL   Nat Genet 54 (12), 1919-1932 (2022)
   PUBMED   36471071
  REMARK    GeneRIF: Enhancer-promoter interactions and transcription are
            largely maintained upon acute loss of CTCF, cohesin, WAPL or YY1.
REFERENCE   6  (residues 1 to 735)
  AUTHORS   Farrell CM, West AG and Felsenfeld G.
  TITLE     Conserved CTCF insulator elements flank the mouse and human
            beta-globin loci
  JOURNAL   Mol Cell Biol 22 (11), 3820-3831 (2002)
   PUBMED   11997516
  REMARK    GeneRIF: Conserved CTCF insulator elements flank the mouse and
            human beta-globin loci.
REFERENCE   7  (residues 1 to 735)
  AUTHORS   Burke LJ, Hollemann T, Pieler T and Renkawitz R.
  TITLE     Molecular cloning and expression of the chromatin insulator protein
            CTCF in Xenopus laevis
  JOURNAL   Mech Dev 113 (1), 95-98 (2002)
   PUBMED   11900981
REFERENCE   8  (residues 1 to 735)
  AUTHORS   Chao W, Huynh KD, Spencer RJ, Davidow LS and Lee JT.
  TITLE     CTCF, a candidate trans-acting factor for X-inactivation choice
  JOURNAL   Science 295 (5553), 345-347 (2002)
   PUBMED   11743158
  REMARK    GeneRIF: It's proposed that Tsix and CTCF together establish a
            regulatable epigenetic switch for X-inactivation.
REFERENCE   9  (residues 1 to 735)
  AUTHORS   Lutz M, Burke LJ, Barreto G, Goeman F, Greb H, Arnold R,
            Schultheiss H, Brehm A, Kouzarides T, Lobanenkov V and Renkawitz R.
  TITLE     Transcriptional repression by the insulator protein CTCF involves
            histone deacetylases
  JOURNAL   Nucleic Acids Res 28 (8), 1707-1713 (2000)
   PUBMED   10734189
REFERENCE   10 (residues 1 to 735)
  AUTHORS   Filippova GN, Fagerlie S, Klenova EM, Myers C, Dehner Y, Goodwin G,
            Neiman PE, Collins SJ and Lobanenkov VV.
  TITLE     An exceptionally conserved transcriptional repressor, CTCF, employs
            different combinations of zinc fingers to bind diverged promoter
            sequences of avian and mammalian c-myc oncogenes
  JOURNAL   Mol Cell Biol 16 (6), 2802-2813 (1996)
   PUBMED   8649389
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127419.3 and AC152826.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422590.581824.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..735
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.04 cM"
     Protein         1..735
                     /product="transcriptional repressor CTCF isoform 2"
                     /note="transcriptional repressor CTCF; CTCFL paralog;
                     11-zinc finger protein"
                     /calculated_mol_wt=83486
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          180..211
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61164.2)"
     Region          266..289
                     /region_name="zf-H2C2_5"
                     /note="C2H2-type zinc-finger domain; pfam13909"
                     /db_xref="CDD:404746"
     Region          268..288
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(268,271,284,288)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:275368"
     Site            order(273,275,277,279..280,283..284,287,301,303,307..308,
                     311..312,315,329,331,333,335..336,339..340,346)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          280..305
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:433230"
     Site            289
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          296..316
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          309..333
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:433230"
     Site            317
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          324..347
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          351..375
                     /region_name="zf-H2C2_5"
                     /note="C2H2-type zinc-finger domain; pfam13909"
                     /db_xref="CDD:404746"
     Region          353..373
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          <366..500
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Site            374
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          381..401
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            402
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          409..426
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          439..457
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          469..489
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(469,472,485,489)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:275368"
     Site            order(474,476,478,480..481,484..485,488,502,504,508..509,
                     512..513,516,530,532,534,536..537,540..541,545)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          497..517
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          509..534
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:433230"
     Region          525..546
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          557..573
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            609
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Site            610
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Site            612
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          698..725
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61164.2)"
     CDS             1..735
                     /gene="Ctcf"
                     /coded_by="NM_001403726.1:496..2703"
                     /note="isoform 2 is encoded by transcript variant 6"
                     /db_xref="GeneID:13018"
                     /db_xref="MGI:MGI:109447"
ORIGIN      
        1 megeaveaiv eesetfikgk erktyqrrre ggqeedachl pqnqtdggev vqdvnssvqm
       61 vmmeqldptl lqmktevmeg tvapeaeaav ddtqiitlqv vnmeeqpini gelqlvqvpv
      121 pvtvpvatts veelqgayen evskeglaes epmichtlpl pegfqvvkvg angevetleq
      181 gelppqedss wqkdpdyqpp akktkktkks klryteegkd vdvsvydfee eqqegllsev
      241 naekvvgnmk ppkptkikkk gvkktfqcel csytcprrsn ldrhmkshtd erphkchlcg
      301 rafrtvtllr nhlnthtgtr phkcpdcdma fvtsgelvrh rrykhthekp fkcsmcdyas
      361 vevsklkrhi rshtgerpfq cslcsyasrd tyklkrhmrt hsgekpyecy icharftqsg
      421 tmkmhilqkh tenvakfhcp hcdtviarks dlgvhlrkqh syieqgkkcr ycdavfhery
      481 aliqhqkshk nekrfkcdqc dyacrqerhm imhkrthtge kpyacshcdk tfrqkqlldm
      541 hfkryhdpnf vpaafvcskc gktftrrntm arhadncagp dgvegengge tkkskrgrkr
      601 kmrskkedss dsenaepdld dneeeeepav eiepepepqp qpppppqpva papppakkrr
      661 grppgrtnqp kqnqptaiiq vedqntgaie niivevkkep daepaegeee eaqaattdap
      721 ngdltpemil smmdr
//
LOCUS       NP_001298044            1556 aa            linear   ROD 09-OCT-2023
DEFINITION  A disintegrin and metalloproteinase with thrombospondin motifs 7
            isoform 2 precursor [Mus musculus].
ACCESSION   NP_001298044 XP_006510824
VERSION     NP_001298044.1
DBSOURCE    REFSEQ: accession NM_001311115.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1556)
  AUTHORS   Sharifi MA, Wierer M, Dang TA, Milic J, Moggio A, Sachs N, von
            Scheidt M, Hinterdobler J, Muller P, Werner J, Stiller B,
            Aherrahrou Z, Erdmann J, Zaliani A, Graettinger M, Reinshagen J,
            Gul S, Gribbon P, Maegdefessel L, Bernhagen J, Sager HB, Mann M,
            Schunkert H and Kessler T.
  TITLE     ADAMTS-7 Modulates Atherosclerotic Plaque Formation by Degradation
            of TIMP-1
  JOURNAL   Circ Res 133 (8), 674-686 (2023)
   PUBMED   37675562
  REMARK    GeneRIF: ADAMTS-7 Modulates Atherosclerotic Plaque Formation by
            Degradation of TIMP-1.
REFERENCE   2  (residues 1 to 1556)
  AUTHORS   Gong Z, Huang J, Wang D, Yang S, Ma Z, Fu Y, Ma Q and Kong W.
  TITLE     ADAMTS-7 deficiency attenuates thoracic aortic aneurysm and
            dissection in mice
  JOURNAL   J Mol Med (Berl) 101 (3), 237-248 (2023)
   PUBMED   36662289
  REMARK    GeneRIF: ADAMTS-7 deficiency attenuates thoracic aortic aneurysm
            and dissection in mice.
REFERENCE   3  (residues 1 to 1556)
  AUTHORS   Ma Z, Mao C, Jia Y, Yu F, Xu P, Tan Y, Zou QH, Zhou XJ, Kong W and
            Fu Y.
  TITLE     ADAMTS7-Mediated Complement Factor H Degradation Potentiates
            Complement Activation to Contributing to Renal Injuries
  JOURNAL   J Am Soc Nephrol 34 (2), 291-308 (2023)
   PUBMED   36735376
  REMARK    GeneRIF: ADAMTS7-Mediated Complement Factor H Degradation
            Potentiates Complement Activation to Contributing to Renal
            Injuries.
REFERENCE   4  (residues 1 to 1556)
  AUTHORS   Jaiswal AK and Mishra A.
  TITLE     ADAMTS7 Attenuates House Dust Mite-Induced Airway Inflammation and
            Th2 Immune Responses
  JOURNAL   Lung 200 (3), 305-313 (2022)
   PUBMED   35503474
  REMARK    GeneRIF: ADAMTS7 Attenuates House Dust Mite-Induced Airway
            Inflammation and Th2 Immune Responses.
REFERENCE   5  (residues 1 to 1556)
  AUTHORS   Mizoguchi T, MacDonald BT, Bhandary B, Popp NR, Laprise D, Arduini
            A, Lai D, Zhu QM, Xing Y, Kaushik VK, Kathiresan S and Ellinor PT.
  TITLE     Coronary Disease Association With ADAMTS7 Is Due to Protease
            Activity
  JOURNAL   Circ Res 129 (4), 458-470 (2021)
   PUBMED   34176299
REFERENCE   6  (residues 1 to 1556)
  AUTHORS   Lai Y, Bai X, Zhao Y, Tian Q, Liu B, Lin EA, Chen Y, Lee B,
            Appleton CT, Beier F, Yu XP and Liu CJ.
  TITLE     ADAMTS-7 forms a positive feedback loop with TNF-alpha in the
            pathogenesis of osteoarthritis
  JOURNAL   Ann Rheum Dis 73 (8), 1575-1584 (2014)
   PUBMED   23928557
  REMARK    GeneRIF: ADAMTS-7 and TNF-alpha form a positive feedback loop in
            the regulation of cartilage degradation and osteoarthritis
            progression.
REFERENCE   7  (residues 1 to 1556)
  AUTHORS   Du J, Takeuchi H, Leonhard-Melief C, Shroyer KR, Dlugosz M,
            Haltiwanger RS and Holdener BC.
  TITLE     O-fucosylation of thrombospondin type 1 repeats restricts
            epithelial to mesenchymal transition (EMT) and maintains epiblast
            pluripotency during mouse gastrulation
  JOURNAL   Dev Biol 346 (1), 25-38 (2010)
   PUBMED   20637190
REFERENCE   8  (residues 1 to 1556)
  AUTHORS   Bai XH, Wang DW, Kong L, Zhang Y, Luan Y, Kobayashi T, Kronenberg
            HM, Yu XP and Liu CJ.
  TITLE     ADAMTS-7, a direct target of PTHrP, adversely regulates
            endochondral bone growth by associating with and inactivating GEP
            growth factor
  JOURNAL   Mol Cell Biol 29 (15), 4201-4219 (2009)
   PUBMED   19487464
  REMARK    GeneRIF: Findings demonstrate that ADAMTS-7, a direct target of
            PTHrP signaling, negatively regulates endochondral bone formation
            by associating with and inactivating GEP chondrogenic growth
            factor.
REFERENCE   9  (residues 1 to 1556)
  AUTHORS   Somerville RP, Longpre JM, Apel ED, Lewis RM, Wang LW, Sanes JR,
            Leduc R and Apte SS.
  TITLE     ADAMTS7B, the full-length product of the ADAMTS7 gene, is a
            chondroitin sulfate proteoglycan containing a mucin domain
  JOURNAL   J Biol Chem 279 (34), 35159-35175 (2004)
   PUBMED   15192113
  REMARK    GeneRIF: ADAMTS7B has a domain organization with a total of eight
            thrombospondin type 1 repeats in its ancillary domain. Of these,
            seven are arranged in two distinct clusters that are separated by a
            mucin domain
REFERENCE   10 (residues 1 to 1556)
  AUTHORS   Hurskainen TL, Hirohata S, Seldin MF and Apte SS.
  TITLE     ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of
            zinc metalloproteases. General features and genomic distribution of
            the ADAM-TS family
  JOURNAL   J Biol Chem 274 (36), 25555-25563 (1999)
   PUBMED   10464288
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY347798.1, CF532146.1,
            BU055903.1, BC058991.1, CB246893.1, CA316195.1 and BQ748923.1.
            
            On Jul 24, 2015 this sequence version replaced XP_006510824.1.
            
            Summary: This gene encodes a member of 'a disintegrin and
            metalloproteinase with thrombospondin motifs' (ADAMTS) family of
            multi-domain matrix-associated metalloendopeptidases that have
            diverse roles in tissue morphogenesis and pathophysiological
            remodeling, in inflammation and in vascular biology. The encoded
            preproprotein undergoes proteolytic processing to generate an
            active, zinc-dependent enzyme that degrades cartilage oligomeric
            matrix protein. The deficiency of the encoded protein decreases
            atherosclerosis in genetically hyperlipidemic mice and in response
            to vascular injury. Alternative splicing results in multiple
            transcript variants encoding different isoforms, some of which may
            undergo similar processing. [provided by RefSeq, May 2016].
            
            Transcript Variant: This variant (2) uses alternate in-frame splice
            sites in the 3' coding region compared to variant 1. It encodes
            isoform 2, which is shorter than isoform 1. This isoform (2) may
            undergo proteolytic processing similar to isoform 4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC145491.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1556
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 47.46 cM"
     Protein         1..1556
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 7 isoform 2 precursor"
                     /EC_number="3.4.24.-"
                     /note="a disintegrin and metalloproteinase with
                     thrombospondin motifs 7; COMPase; a disintegrin-like and
                     metalloprotease (reprolysin type) with thrombospondin type
                     1 motif, 7; a disintegrin-like and metallopeptidase
                     (reprolysin type) with thrombospondin type 1 motif, 7"
                     /calculated_mol_wt=169162
     sig_peptide     1..24
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=2433
     Region          34..174
                     /region_name="Pep_M12B_propep"
                     /note="Reprolysin family propeptide; pfam01562"
                     /db_xref="CDD:426325"
     Region          226..434
                     /region_name="ZnMc_ADAMTS_like"
                     /note="Zinc-dependent metalloprotease, ADAMTS_like
                     subgroup. ADAMs (A Disintegrin And Metalloprotease) are
                     glycoproteins, which play roles in cell signaling, cell
                     fusion, and cell-cell interactions. This particular
                     subfamily represents domain architectures that...;
                     cd04273"
                     /db_xref="CDD:239801"
     Site            order(372..373,376,382)
                     /site_type="active"
                     /db_xref="CDD:239801"
     Region          449..513
                     /region_name="ADAM_CR_2"
                     /note="ADAM cysteine-rich domain; pfam17771"
                     /db_xref="CDD:436031"
     Region          526..578
                     /region_name="TSP1"
                     /note="Thrombospondin type 1 repeats; smart00209"
                     /db_xref="CDD:214559"
     Region          584..682
                     /region_name="ADAM_CR_3"
                     /note="ADAM cysteine-rich domain; pfam19236"
                     /db_xref="CDD:437068"
     Region          684..793
                     /region_name="ADAM_spacer1"
                     /note="ADAM-TS Spacer 1; pfam05986"
                     /db_xref="CDD:428708"
     Region          808..862
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:408800"
     Region          866..922
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:408800"
     Region          <1016..1302
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          1285..1333
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:408800"
     Region          1336..1391
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:408800"
     Region          1394..1440
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:408800"
     Region          1443..1498
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:408800"
     CDS             1..1556
                     /gene="Adamts7"
                     /gene_synonym="ADAM-TS7; ADAMTS7B"
                     /coded_by="NM_001311115.1:268..4938"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2"
                     /db_xref="CCDS:CCDS81050.1"
                     /db_xref="GeneID:108153"
                     /db_xref="MGI:MGI:1347346"
ORIGIN      
        1 mhrgpsllli lcalasrvlg pasglvtegr agldivhpvr vdaggsflsy elwprvlrkr
       61 dvsttqassa fyqlqyqgre llfnlttnpy lmapgfvsei rrhstlghah iqtsvptchl
      121 lgdvqdpele ggfaaisacd glrgvfqlsn edyfiepldg vsaqpghaqp hvvykhqgsr
      181 kqaqqgdsrp sgtcgmqvpp dleqqrehwe qqqqkrrqqr svskekwvet lvvadskmve
      241 yhgqpqvesy vltimnmvag lfhdpsignp ihisivrlii ledeekdlki thhaeetlkn
      301 fcrwqknini kgddhpqhhd tailltrkdl casmnqpcet lglshvsglc hpqlscsvse
      361 dtgmplaftv ahelghsfgi qhdgtgndce sigkrpfims pqllydrgip ltwsrcsrey
      421 itrfldrgwg lclddrpskd vialpsvlpg vlydvnhqcr lqygshsayc edmddvchtl
      481 wcsvgttchs kldaavdgts cgknkwclkg ecvpegfqpe avdggwsgws awsdcsrscg
      541 vgvrsserqc tqpvpknrgk ycvgerkrsq lcnlpacppd rpsfrhtqcs qfdgmlykgk
      601 lhkwvpvpnd dnpcelhcrp snssnteklr davvdgtpcy qsrisrdicl ngicknvgcd
      661 fvidsgaeed rcgvcrgdgs tcqtvsrtfk etegqgyvdi glipagarei lieevaeaan
      721 flalrsedpd kyflnggwti qwngdyrvag ttftyarkgn wenltspgpt sepvwiqllf
      781 qeknpgvhyq ytiqrdshdq vrppefswhy gpwskctvtc gtgvqrqsly cmerqagvva
      841 eeycntlnrp derqrkcsee pcpprwwage wqpcsrscgp eglsrravfc irsmgldeqr
      901 alelsacehl prplaetpcn rhvicpstwg vgnwsqypmy ivdtgasgsg ssspelfnev
      961 dfipnqlapr pspasspkpv sisnaideee ldppgpvfvd dfyydynfin fhedlsygsf
     1021 eephpdlvdn ggwtapphir ptespsdtpv ptagalgaea ediqgswsps pllseasysp
     1081 pgleqtsinp lanflteedt pmgapelgfp slpwppasvd dmmtpvgpgn pdellvkede
     1141 qsppstpwsd rnklstdgnp lghtspalpq spiptqpspp sisptqasps pdvvevstgw
     1201 naawdpvlea dlkpghvptd lrspgpsgqp qtpnlegtqs pgllptpare tqtnsskdpe
     1261 vqplqpslee dgdpadplpa rnaswqvgnw sqcsttcglg aiwrlvscss gndedctlas
     1321 rpqparhchl rpcaawrtgn wskcsrncgg gsstrdvqcv dtrdlrplrp fhcqpgptkp
     1381 pnrqlcgtqp clpwytsswr ecseacggge qqrlvtcpep glceeslrpn nsrpcnthpc
     1441 tqwvvgpwgq csapcgggvq rrlvrcvntq tglaeedsdl csheawpess rpcatedcel
     1501 vepprcerdr lsfnfcetlr llgrcqlpti raqccrscpp lsrgvpsrgh qrvarr
//
LOCUS       NP_001349253             483 aa            linear   ROD 09-OCT-2023
DEFINITION  CUGBP Elav-like family member 4 isoform 42 [Mus musculus].
ACCESSION   NP_001349253
VERSION     NP_001349253.1
DBSOURCE    REFSEQ: accession NM_001362324.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 483)
  AUTHORS   Salamon I, Park Y, Miskic T, Kopic J, Matteson P, Page NF, Roque A,
            McAuliffe GW, Favate J, Garcia-Forn M, Shah P, Judas M, Millonig
            JH, Kostovic I, De Rubeis S, Hart RP, Krsnik Z and Rasin MR.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    GeneRIF: Celf4 controls mRNA translation underlying synaptic
            development in the prenatal mammalian neocortex.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 483)
  AUTHORS   Shen Y, Zhang C, Xiao K, Liu D and Xie G.
  TITLE     CELF4 regulates spine formation and depression-like behaviors of
            mice
  JOURNAL   Biochem Biophys Res Commun 605, 39-44 (2022)
   PUBMED   35306363
  REMARK    GeneRIF: CELF4 regulates spine formation and depression-like
            behaviors of mice.
REFERENCE   3  (residues 1 to 483)
  AUTHORS   Moreau MX, Saillour Y, Cwetsch AW, Pierani A and Causeret F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   4  (residues 1 to 483)
  AUTHORS   Li C, Li X, Bi Z, Sugino K, Wang G, Zhu T and Liu Z.
  TITLE     Comprehensive transcriptome analysis of cochlear spiral ganglion
            neurons at multiple ages
  JOURNAL   Elife 9, e50491 (2020)
   PUBMED   31913118
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 483)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 483)
  AUTHORS   Ladd AN, Taffet G, Hartley C, Kearney DL and Cooper TA.
  TITLE     Cardiac tissue-specific repression of CELF activity disrupts
            alternative splicing and causes cardiomyopathy
  JOURNAL   Mol Cell Biol 25 (14), 6267-6278 (2005)
   PUBMED   15988035
  REMARK    GeneRIF: CELF protein activity is required for normal alternative
            splicing in the heart in vivo and normal CELF-mediated alternative
            splicing regulation is in turn required for normal cardiac
            function.
REFERENCE   7  (residues 1 to 483)
  AUTHORS   Meins M, Schlickum S, Wilhelm C, Missbach J, Yadav S, Glaser B,
            Grzmil M, Burfeind P and Laccone F.
  TITLE     Identification and characterization of murine Brunol4, a new member
            of the elav/bruno family
  JOURNAL   Cytogenet Genome Res 97 (3-4), 254-260 (2002)
   PUBMED   12438720
  REMARK    GeneRIF: cloning and characterization
REFERENCE   8  (residues 1 to 483)
  AUTHORS   Ladd AN, Charlet N and Cooper TA.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   9  (residues 1 to 483)
  AUTHORS   Good PJ, Chen Q, Warner SJ and Herring DC.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
REFERENCE   10 (residues 1 to 483)
  AUTHORS   Yulug IG, Egan SE, See CG and Fisher EM.
  TITLE     Mapping GRB2, a signal transduction gene in the human and the mouse
  JOURNAL   Genomics 22 (2), 313-318 (1994)
   PUBMED   7806216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121094.8 and AC144938.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.4930.1,
                                           SRR1660817.163922.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..483
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 13.92 cM"
     Protein         1..483
                     /product="CUGBP Elav-like family member 4 isoform 42"
                     /note="CUG-BP- and ETR-3-like factor 4; bruno-like protein
                     4; RNA-binding protein BRUNOL-4; bruno-like 4, RNA binding
                     protein"
                     /calculated_mol_wt=51511
     Region          18..39
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          49..135
                     /region_name="RRM1_CELF3_4_5_6"
                     /note="RNA recognition motif 1 (RRM1) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12632"
                     /db_xref="CDD:410041"
     Site            order(55,57,59..60,63,82,84,86,95..97,99,129,131)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410041"
     Region          121..149
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          150..230
                     /region_name="RRM2_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12635"
                     /db_xref="CDD:410043"
     Site            order(152,154,156..157,160,179,181,183,191..193,195,225,
                     227)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410043"
     Region          238..257
                     /region_name="Necessary for TNNT2 exon 5 inclusion.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          414..472
                     /region_name="RRM_SF"
                     /note="RNA recognition motif (RRM) superfamily; cl17169"
                     /db_xref="CDD:450164"
     CDS             1..483
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /coded_by="NM_001362324.1:531..1982"
                     /note="isoform 42 is encoded by transcript variant 44"
                     /db_xref="GeneID:108013"
                     /db_xref="MGI:MGI:1932407"
ORIGIN      
        1 myikmatlan gqadnaslst nglgsspgsa ghmnglshsp gnpstipmkd hdaiklfigq
       61 iprnldekdl kplfeefgki yeltvlkdrf tgmhkgcafl tyceresalk aqsalheqkt
      121 lpgmnrpiqv kpadsesrgg ssclrqppsh rklfvgmlnk qqseddvrrl feafgnieec
      181 tilrgpdgns kgcafvkyss haeaqaaina lhgsqtmpga ssslvvkfad tdkertmrrm
      241 qqmagqmgmf npmaipfgay gayaqamqqq aalmasvaqg gylnpmaafa aaqmqqmaal
      301 nmnglaaapm tptsggstpp gitapavpsi pspigvngft glppqangqp aaeavfangi
      361 hpypaqspta adplqqayag vqqyagpayp aaygqisqaf pqpppmipqq qregpegcnl
      421 liyhlpqefg daelmqmflp fgfvsfdnpa saqtaiqamn gfqigmkrlk vqlkrpkdan
      481 rpy
//
LOCUS       NP_031441               1014 aa            linear   ROD 09-OCT-2023
DEFINITION  poly [ADP-ribose] polymerase 1 [Mus musculus].
ACCESSION   NP_031441
VERSION     NP_031441.2
DBSOURCE    REFSEQ: accession NM_007415.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1014)
  AUTHORS   Xiao D, Zeng T, Zhu W, Yu ZZ, Huang W, Yi H, Lu SS, Feng J, Feng
            XP, Wu D, Wen Q, Zhou JH, Yuan L, Zhuang W and Xiao ZQ.
  TITLE     ANXA1 Promotes Tumor Immune Evasion by Binding PARP1 and
            Upregulating Stat3-Induced Expression of PD-L1 in Multiple Cancers
  JOURNAL   Cancer Immunol Res 11 (10), 1367-1383 (2023)
   PUBMED   37566399
  REMARK    GeneRIF: ANXA1 Promotes Tumor Immune Evasion by Binding PARP1 and
            Upregulating Stat3-Induced Expression of PD-L1 in Multiple Cancers.
REFERENCE   2  (residues 1 to 1014)
  AUTHORS   Kamaletdinova T, Zong W, Urbanek P, Wang S, Sannai M, Grigaravicius
            P, Sun W, Fanaei-Kahrani Z, Mangerich A, Hottiger MO, Li T and Wang
            ZQ.
  TITLE     Poly(ADP-Ribose) Polymerase-1 Lacking Enzymatic Activity Is Not
            Compatible with Mouse Development
  JOURNAL   Cells 12 (16), 2078 (2023)
   PUBMED   37626888
  REMARK    GeneRIF: Poly(ADP-Ribose) Polymerase-1 Lacking Enzymatic Activity
            Is Not Compatible with Mouse Development.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1014)
  AUTHORS   Chen W, E Q, Sun B, Zhang P, Li N, Fei S, Wang Y, Liu S, Liu X and
            Zhang X.
  TITLE     PARP1-catalyzed PARylation of YY1 mediates endoplasmic reticulum
            stress in granulosa cells to determine primordial follicle
            activation
  JOURNAL   Cell Death Dis 14 (8), 524 (2023)
   PUBMED   37582914
  REMARK    GeneRIF: PARP1-catalyzed PARylation of YY1 mediates endoplasmic
            reticulum stress in granulosa cells to determine primordial
            follicle activation.
            Erratum:[Cell Death Dis. 2023 Oct 5;14(10):650. PMID: 37798270]
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1014)
  AUTHORS   Xu W, Yang Y, Yu Y, Wen C, Zhao S, Cao L, Zhao S, Qin Y and Chen
            ZJ.
  TITLE     FAAP100 is required for the resolution of transcription-replication
            conflicts in primordial germ cells
  JOURNAL   BMC Biol 21 (1), 174 (2023)
   PUBMED   37580696
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1014)
  AUTHORS   Shao Z, Lee BJ, Zhang H, Lin X, Li C, Jiang W, Chirathivat N,
            Gershik S, Shen MM, Baer R and Zha S.
  TITLE     Inactive PARP1 causes embryonic lethality and genome instability in
            a dominant-negative manner
  JOURNAL   Proc Natl Acad Sci U S A 120 (31), e2301972120 (2023)
   PUBMED   37487079
  REMARK    GeneRIF: Inactive PARP1 causes embryonic lethality and genome
            instability in a dominant-negative manner.
REFERENCE   6  (residues 1 to 1014)
  AUTHORS   Wang ZQ, Auer B, Stingl L, Berghammer H, Haidacher D, Schweiger M
            and Wagner EF.
  TITLE     Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but
            are susceptible to skin disease
  JOURNAL   Genes Dev 9 (5), 509-520 (1995)
   PUBMED   7698643
REFERENCE   7  (residues 1 to 1014)
  AUTHORS   Sugiyama S, Utani A, Yamada S, Kozak CA and Yamada Y.
  TITLE     Cloning and expression of the mouse laminin gamma 2 (B2t) chain, a
            subunit of epithelial cell laminin
  JOURNAL   Eur J Biochem 228 (1), 120-128 (1995)
   PUBMED   7882992
REFERENCE   8  (residues 1 to 1014)
  AUTHORS   Auer B, Flick K, Wang ZQ, Haidacher D, Jager S, Berghammer H,
            Kofler B, Schweiger M and Wagner EF.
  TITLE     On the biological role of the nuclear polymerizing NAD+:
            protein(ADP-ribosyl) transferase (ADPRT): ADPRT from Dictyostelium
            discoideum and inactivation of the ADPRT gene in the mouse
  JOURNAL   Biochimie 77 (6), 444-449 (1995)
   PUBMED   7578427
REFERENCE   9  (residues 1 to 1014)
  AUTHORS   Hupp K, Siwarski D, Mock BA and Kinet JP.
  TITLE     Gene mapping of the three subunits of the high affinity FcR for IgE
            to mouse chromosomes 1 and 19
  JOURNAL   J Immunol 143 (11), 3787-3791 (1989)
   PUBMED   2531187
REFERENCE   10 (residues 1 to 1014)
  AUTHORS   Huppi K, Bhatia K, Siwarski D, Klinman D, Cherney B and Smulson M.
  TITLE     Sequence and organization of the mouse poly (ADP-ribose) polymerase
            gene
  JOURNAL   Nucleic Acids Res 17 (9), 3387-3401 (1989)
   PUBMED   2498841
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ153239.1, AK159433.1 and AC167020.3.
            
            On May 16, 2002 this sequence version replaced NP_031441.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK088679.1, AK166104.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1014
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 84.44 cM"
     Protein         1..1014
                     /product="poly [ADP-ribose] polymerase 1"
                     /EC_number="2.4.2.30"
                     /note="ADP-ribosyltransferase diphtheria toxin-like 1;
                     ADP-ribosyltransferase (NAD+, poly (ADP-ribose)
                     polymerase) 1; ADPRT 1; poly[ADP-ribose] synthetase 1;
                     NAD(+) ADP-ribosyltransferase 1; poly[ADP-ribose] synthase
                     1; poly(ADP-ribose) polymerase; DNA ADP-ribosyltransferase
                     PARP1; protein poly-ADP-ribosyltransferase PARP1"
                     /calculated_mol_wt=112591
     Region          9..1010
                     /region_name="PLN03123"
                     /note="poly [ADP-ribose] polymerase; Provisional"
                     /db_xref="CDD:215590"
     CDS             1..1014
                     /gene="Parp1"
                     /gene_synonym="5830444G22Rik; Adprp; Adprt1; ARTD1;
                     msPARP; PARP; parp-1; PPOL; sPARP-1"
                     /coded_by="NM_007415.3:144..3188"
                     /db_xref="CCDS:CCDS15569.1"
                     /db_xref="GeneID:11545"
                     /db_xref="MGI:MGI:1340806"
ORIGIN      
        1 maeaserlyr veyaksgras ckkcsesipk dslrmaimvq spmfdgkvph wyhfscfwkv
       61 ghsirqpdve vdgfselrwd dqqkvkktae aggvagkgqd gsggkaektl gdflaeyaks
      121 nrsmckgcle kiekgqmrls kkmvdpekpq lgmidrwyhp tcfvkkrdel gfrpeysasq
      181 lkgfsllsae dkealkkqlp aiknegkrkg devdgtdeva kkkskkgkdk dssklekalk
      241 aqneliwnik delkkacstn dlkellifnq qqvpsgesai ldrvadgmaf gallpckecs
      301 gqlvfksday yctgdvtawt kcmvktqnps rkewvtpkef reisylkklk vkkqdrifpp
      361 essapaplal plsvtsapta vnssapadkp lsnmkiltlg klsqnkdeak avieklggkl
      421 tgsankaslc istkkevekm skkmeevkaa nvrvvcedfl qdvsastksl qellsahsls
      481 swgaevkaep gevvapkgks aapskkskga vkeegvnkse krmkltlkgg aavdpdsgle
      541 hsahvlekgg kvfsatlglv divkgtnsyy klqlleddke srywifrswg rvgtvigsnk
      601 leqmpskeda vehfmklyee ktgnawhskn ftkypkkfyp leidygqdee avkkltvkpg
      661 tksklpkpvq elvgmifdve smkkalveye idlqkmplgk lsrrqiqaay silsevqqav
      721 sqgssesqil dlsnrfytli phdfgmkkpp llnnadsvqa kvemldnlld ievaysllrg
      781 gsddsskdpi dvnyeklktd ikvvdrdsee aevirkyvkn thatthnayd levidifkie
      841 regesqrykp frqlhnrrll whgsrttnfa gilsqglria ppeapvtgym fgkgiyfadm
      901 vsksanycht sqgdpiglil lgevalgnmy elkhashisk lpkgkhsvkg lgkttpdpsa
      961 sitlegvevp lgtgipsgvn dtcllyneyi vydiaqvnlk yllklkfnfk tslw
//
LOCUS       NP_035995                356 aa            linear   ROD 09-OCT-2023
DEFINITION  poly(rC)-binding protein 1 [Mus musculus].
ACCESSION   NP_035995
VERSION     NP_035995.1
DBSOURCE    REFSEQ: accession NM_011865.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 356)
  AUTHORS   Yang ZY, Zhang WL, Jiang CW and Sun G.
  TITLE     PCBP1-mediated regulation of WNT signaling is critical for breast
            tumorigenesis
  JOURNAL   Cell Biol Toxicol 39 (5), 2331-2343 (2023)
   PUBMED   35639300
  REMARK    GeneRIF: PCBP1-mediated regulation of WNT signaling is critical for
            breast tumorigenesis.
REFERENCE   2  (residues 1 to 356)
  AUTHORS   Yang X, Yabe-Wada T, Han J, Saito F, Ogasawara C, Yamada S and Onai
            N.
  TITLE     PCBP1 acts as a regulator of CCL2 expression in macrophages to
            induce recruitment of monocyte-derived macrophages into the
            inflamed colon
  JOURNAL   Int Immunol 35 (6), 287-299 (2023)
   PUBMED   36702545
  REMARK    GeneRIF: PCBP1 acts as a regulator of CCL2 expression in
            macrophages to induce recruitment of monocyte-derived macrophages
            into the inflamed colon.
REFERENCE   3  (residues 1 to 356)
  AUTHORS   Grelet S, Frereux C, Obellianne C, Noguchi K, Howley BV, Dalton AC
            and Howe PH.
  TITLE     TGFbeta-induced expression of long noncoding lincRNA Platr18
            controls breast cancer axonogenesis
  JOURNAL   Life Sci Alliance 5 (2), e202101261 (2021)
   PUBMED   34810279
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 356)
  AUTHORS   Ji X, Jha A, Humenik J, Ghanem LR, Kromer A, Duncan-Lewis C,
            Traxler E, Weiss MJ, Barash Y and Liebhaber SA.
  TITLE     RNA-Binding Proteins PCBP1 and PCBP2 Are Critical Determinants of
            Murine Erythropoiesis
  JOURNAL   Mol Cell Biol 41 (9), e0066820 (2021)
   PUBMED   34180713
  REMARK    GeneRIF: RNA-Binding Proteins PCBP1 and PCBP2 Are Critical
            Determinants of Murine Erythropoiesis.
REFERENCE   5  (residues 1 to 356)
  AUTHORS   Mohanty BK, Karam JA, Howley BV, Dalton AC, Grelet S, Dincman T,
            Streitfeld WS, Yoon JH, Balakrishnan L, Chazin WJ, Long DT and Howe
            PH.
  TITLE     Heterogeneous nuclear ribonucleoprotein E1 binds polycytosine DNA
            and monitors genome integrity
  JOURNAL   Life Sci Alliance 4 (9), e202000995 (2021)
   PUBMED   34272328
  REMARK    GeneRIF: Heterogeneous nuclear ribonucleoprotein E1 binds
            polycytosine DNA and monitors genome integrity.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 356)
  AUTHORS   Papin J and Subramaniam S.
  TITLE     Bioinformatics and cellular signaling
  JOURNAL   Curr Opin Biotechnol 15 (1), 78-81 (2004)
   PUBMED   15102471
  REMARK    Review article
REFERENCE   7  (residues 1 to 356)
  AUTHORS   Li KW, Hornshaw MP, Van Der Schors RC, Watson R, Tate S, Casetta B,
            Jimenez CR, Gouwenberg Y, Gundelfinger ED, Smalla KH and Smit AB.
  TITLE     Proteomics analysis of rat brain postsynaptic density. Implications
            of the diverse protein functional groups for the integration of
            synaptic physiology
  JOURNAL   J Biol Chem 279 (2), 987-1002 (2004)
   PUBMED   14532281
REFERENCE   8  (residues 1 to 356)
  AUTHORS   Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S,
            Bono H, Okazaki Y and Hayashizaki Y.
  TITLE     Protein-protein interaction panel using mouse full-length cDNAs
  JOURNAL   Genome Res 11 (10), 1758-1765 (2001)
   PUBMED   11591653
REFERENCE   9  (residues 1 to 356)
  AUTHORS   Bedford MT, Sarbassova D, Xu J, Leder P and Yaffe MB.
  TITLE     A novel pro-Arg motif recognized by WW domains
  JOURNAL   J Biol Chem 275 (14), 10359-10369 (2000)
   PUBMED   10744724
REFERENCE   10 (residues 1 to 356)
  AUTHORS   Makeyev AV, Chkheidze AN and Liebhaber SA.
  TITLE     A set of highly conserved RNA-binding proteins, alphaCP-1 and
            alphaCP-2, implicated in mRNA stabilization, are coexpressed from
            an intronless gene and its intron-containing paralog
  JOURNAL   J Biol Chem 274 (35), 24849-24857 (1999)
   PUBMED   10455157
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153374.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC069915.1, AF139894.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..356
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 37.72 cM"
     Protein         1..356
                     /product="poly(rC)-binding protein 1"
                     /note="heterogeneous nuclear ribonucleoprotein E1;
                     alpha-CP1"
                     /calculated_mol_wt=37367
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:Q15365; propagated from
                     UniProtKB/Swiss-Prot (P60335.1)"
     Region          13..82
                     /region_name="KH-I_PCBP1_2_rpt1"
                     /note="first type I K homology (KH) RNA-binding domain
                     found in poly(rC)-binding protein 1 (PCBP1) and similar
                     proteins; cd22515"
                     /db_xref="CDD:411943"
     Site            order(22,26..27,29..33,36,40,48..51,53,57)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:411943"
     Region          92..169
                     /region_name="KH-I_PCBP1_2_rpt2"
                     /note="second type I K homology (KH) RNA-binding domain
                     found in poly(rC)-binding protein 1 (PCBP1) and similar
                     proteins; cd22518"
                     /db_xref="CDD:411946"
     Site            order(105,110..111,113..117,120,124,132..134,140,144)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:411946"
     Site            173
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19131326,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P60335.1)"
     Site            189
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P60335.1)"
     Site            190
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P60335.1)"
     Site            246
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q15365; propagated from
                     UniProtKB/Swiss-Prot (P60335.1)"
     Site            264
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q15365; propagated from
                     UniProtKB/Swiss-Prot (P60335.1)"
     Site            273
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q15365; propagated from
                     UniProtKB/Swiss-Prot (P60335.1)"
     Region          276..351
                     /region_name="KH-I_PCBP1_2_rpt3"
                     /note="third type I K homology (KH) RNA-binding domain
                     found in poly(rC)-binding protein 1 (PCBP1) and similar
                     proteins; cd22521"
                     /db_xref="CDD:411949"
     Site            order(289..293,295..299,301..303,306,314..315,317,325,350)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:411949"
     CDS             1..356
                     /gene="Pcbp1"
                     /gene_synonym="alphaCP-1; hnRNP E1; hnRNP-E1; WBP17;
                     [a]CP-1"
                     /coded_by="NM_011865.4:275..1345"
                     /db_xref="CCDS:CCDS20314.1"
                     /db_xref="GeneID:23983"
                     /db_xref="MGI:MGI:1345635"
ORIGIN      
        1 mdagvtesgl nvtltirllm hgkevgsiig kkgesvkrir eesgarinis egncperiit
       61 ltgptnaifk afamiidkle edinssmtns taasrppvtl rlvvpatqcg sligkggcki
      121 keirestgaq vqvagdmlpn steraitiag vpqsvtecvk qiclvmletl sqspqgrvmt
      181 ipyqpmpass pvicaggqdr csdaagypha thdlegppld aysiqgqhti spldlaklnq
      241 varqqshfam mhggtgfagi dssspevkgy wasldastqt theltipnnl igciigrqga
      301 nineirqmsg aqikianpve gssgrqvtit gsaasislaq ylinarlsse kgmgcs
//
LOCUS       NP_001397159             491 aa            linear   ROD 09-OCT-2023
DEFINITION  nuclear respiratory factor 1 isoform h [Mus musculus].
ACCESSION   NP_001397159
VERSION     NP_001397159.1
DBSOURCE    REFSEQ: accession NM_001410230.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 491)
  AUTHORS   Cheng C, Tian Y, Yang R, Guo W, Xiao K, Zhang F, Tian J, Deng Z,
            Yang W, Yang H and Zhou Z.
  TITLE     miR-5581 Contributes to Osteoarthritis by Targeting NRF1 to Disturb
            the Proliferation and Functions of Chondrocytes
  JOURNAL   Am J Pathol 193 (9), 1234-1247 (2023)
   PUBMED   37611970
  REMARK    GeneRIF: miR-5581 Contributes to Osteoarthritis by Targeting NRF1
            to Disturb the Proliferation and Functions of Chondrocytes.
REFERENCE   2  (residues 1 to 491)
  AUTHORS   Meng Z, Liang B, Wu Y, Liu C, Wang H, Du Y, Gan L, Gao E, Lau WB,
            Christopher TA, Lopez BL, Koch WJ, Ma X, Zhao F, Wang Y and Zhao J.
  TITLE     Hypoadiponectinemia-induced upregulation of microRNA449b
            downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury
            in diabetic mice
  JOURNAL   J Mol Cell Cardiol 182, 1-14 (2023)
   PUBMED   37437402
  REMARK    GeneRIF: Hypoadiponectinemia-induced upregulation of microRNA449b
            downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury
            in diabetic mice.
REFERENCE   3  (residues 1 to 491)
  AUTHORS   Zhao T, Zhang J, Lei H, Meng Y, Cheng H, Zhao Y, Geng G, Mu C, Chen
            L, Liu Q, Luo Q, Zhang C, Long Y, Su J, Wang Y, Li Z, Sun J, Chen
            G, Li Y, Liao X, Shang Y, Hu G, Chen Q and Zhu Y.
  TITLE     NRF1-mediated mitochondrial biogenesis antagonizes innate antiviral
            immunity
  JOURNAL   EMBO J 42 (16), e113258 (2023)
   PUBMED   37409632
  REMARK    GeneRIF: NRF1-mediated mitochondrial biogenesis antagonizes innate
            antiviral immunity.
REFERENCE   4  (residues 1 to 491)
  AUTHORS   Akl MG, Baccetto R, Stebbings BM, Li L and Widenmaier SB.
  TITLE     Euglycemia is affected by stress defense factor hepatocyte NRF1,
            but not NRF2
  JOURNAL   Biochem Biophys Res Commun 668, 96-103 (2023)
   PUBMED   37245295
  REMARK    GeneRIF: Euglycemia is affected by stress defense factor hepatocyte
            NRF1, but not NRF2.
REFERENCE   5  (residues 1 to 491)
  AUTHORS   Akl MG, Li L, Baccetto R, Phanse S, Zhang Q, Trites MJ, McDonald S,
            Aoki H, Babu M and Widenmaier SB.
  TITLE     Complementary gene regulation by NRF1 and NRF2 protects against
            hepatic cholesterol overload
  JOURNAL   Cell Rep 42 (4), 112399 (2023)
   PUBMED   37060561
  REMARK    GeneRIF: Complementary gene regulation by NRF1 and NRF2 protects
            against hepatic cholesterol overload.
            Erratum:[Cell Rep. 2023 Jul 25;42(7):112872. PMID: 37454293]
REFERENCE   6  (residues 1 to 491)
  AUTHORS   Carmona MC, Iglesias R, Obregon MJ, Darlington GJ, Villarroya F and
            Giralt M.
  TITLE     Mitochondrial biogenesis and thyroid status maturation in brown fat
            require CCAAT/enhancer-binding protein alpha
  JOURNAL   J Biol Chem 277 (24), 21489-21498 (2002)
   PUBMED   11940593
REFERENCE   7  (residues 1 to 491)
  AUTHORS   Huo L and Scarpulla RC.
  TITLE     Mitochondrial DNA instability and peri-implantation lethality
            associated with targeted disruption of nuclear respiratory factor 1
            in mice
  JOURNAL   Mol Cell Biol 21 (2), 644-654 (2001)
   PUBMED   11134350
REFERENCE   8  (residues 1 to 491)
  AUTHORS   Schaefer L, Engman H and Miller JB.
  TITLE     Coding sequence, chromosomal localization, and expression pattern
            of Nrf1: the mouse homolog of Drosophila erect wing
  JOURNAL   Mamm Genome 11 (2), 104-110 (2000)
   PUBMED   10656923
REFERENCE   9  (residues 1 to 491)
  AUTHORS   Huo L and Scarpulla RC.
  TITLE     Multiple 5'-untranslated exons in the nuclear respiratory factor 1
            gene span 47 kb and contribute to transcript heterogeneity and
            translational efficiency
  JOURNAL   Gene 233 (1-2), 213-224 (1999)
   PUBMED   10375638
REFERENCE   10 (residues 1 to 491)
  AUTHORS   Virbasius CA, Virbasius JV and Scarpulla RC.
  TITLE     NRF-1, an activator involved in nuclear-mitochondrial interactions,
            utilizes a new DNA-binding domain conserved in a family of
            developmental regulators
  JOURNAL   Genes Dev 7 (12A), 2431-2445 (1993)
   PUBMED   8253388
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134897.4 and AC153632.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784648.1336702.1,
                                           SRR12282455.3925931.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 12.47 cM"
     Protein         1..491
                     /product="nuclear respiratory factor 1 isoform h"
                     /note="NRF-1; alpha-pal; alpha palindromic-binding
                     protein"
                     /calculated_mol_wt=52353
     Region          87..295
                     /region_name="Nrf1_DNA-bind"
                     /note="NLS-binding and DNA-binding and dimerization
                     domains of Nrf1; pfam10491"
                     /db_xref="CDD:402218"
     CDS             1..491
                     /gene="Nrf1"
                     /gene_synonym="D6Ertd415e"
                     /coded_by="NM_001410230.1:271..1746"
                     /note="isoform h is encoded by transcript variant 20"
                     /db_xref="GeneID:18181"
                     /db_xref="MGI:MGI:1332235"
ORIGIN      
        1 meehgvtqte hmatieahav aqqvqqvhva tytehsmlsa dedspssped tsyddsdiln
       61 staadevtah laaavlgikp rashilgpvg maaaaavatg kkrkrphvfe snpsirkrqq
      121 trllrklrat ldeyttrvgq qaivlcisps kpnpvfkvfg aaplenvvrk yksmiledle
      181 salaehapap qevnselppl tidgipvsvd kmtqaqlraf ipemlkystg rgkpgwgkes
      241 ckpiwwpedi pwanvrsdvr teeqkqrvsw tqalrtivkn cykqhgredl lyafedqqtq
      301 tqattthsia hlvpsqtvvq tfsnpdgtvs liqvgtgatv atladaselp ttvtvaqvny
      361 savadgeveq nwatlqggem tiqttqasea tqavaslaea avaasqemqq gatvtmalns
      421 eaaahavatl aeatlqgggq ivlsgetaaa vgaltgvqda nglfmadcgg ykwilarrlq
      481 vgsslgregs s
//
LOCUS       NP_001342406             657 aa            linear   ROD 09-OCT-2023
DEFINITION  broad substrate specificity ATP-binding cassette transporter ABCG2
            [Mus musculus].
ACCESSION   NP_001342406 XP_006506214
VERSION     NP_001342406.1
DBSOURCE    REFSEQ: accession NM_001355477.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 657)
  AUTHORS   Notsu T, Kurata Y, Ninomiya H, Taufiq F, Komatsu K, Miake J, Sawano
            T, Tsuneto M, Shirayoshi Y and Hisatome I.
  TITLE     Inhibition of the uric acid efflux transporter ABCG2 enhances
            stimulating effect of soluble uric acid on IL-1beta production in
            murine macrophage-like J774.1 cells
  JOURNAL   Hypertens Res 46 (10), 2368-2377 (2023)
   PUBMED   37592041
  REMARK    GeneRIF: Inhibition of the uric acid efflux transporter ABCG2
            enhances stimulating effect of soluble uric acid on IL-1beta
            production in murine macrophage-like J774.1 cells.
REFERENCE   2  (residues 1 to 657)
  AUTHORS   Harby SA, Khalil NA, El-Sayed NS, Thabet EH, Saleh SR and Fathelbab
            MH.
  TITLE     Implications of BCRP modulation on PTZ-induced seizures in mice:
            Role of ko143 and metformin as adjuvants to lamotrigine
  JOURNAL   Naunyn Schmiedebergs Arch Pharmacol 396 (10), 2627-2636 (2023)
   PUBMED   37067582
  REMARK    GeneRIF: Implications of BCRP modulation on PTZ-induced seizures in
            mice: Role of ko143 and metformin as adjuvants to lamotrigine.
REFERENCE   3  (residues 1 to 657)
  AUTHORS   Blanco-Paniagua E, Alvarez-Fernandez L, Rodriguez-Alonso A,
            Millan-Garcia A, Alvarez AI and Merino G.
  TITLE     Role of the Abcg2 Transporter in Secretion into Milk of the
            Anthelmintic Clorsulon: Interaction with Ivermectin
  JOURNAL   Antimicrob Agents Chemother 67 (5), e0009523 (2023)
   PUBMED   37078871
  REMARK    GeneRIF: Role of the Abcg2 Transporter in Secretion into Milk of
            the Anthelmintic Clorsulon: Interaction with Ivermectin.
REFERENCE   4  (residues 1 to 657)
  AUTHORS   Wu C, Xiao Y, Wu C, Xie D, Luo M, Yao D, Chen M and Lu D.
  TITLE     Regulation of BCRP expression and sulfasalazine pharmacokinetics by
            the nuclear receptor REV-ERBalpha
  JOURNAL   Xenobiotica 53 (3), 215-222 (2023)
   PUBMED   37039301
  REMARK    GeneRIF: Regulation of BCRP expression and sulfasalazine
            pharmacokinetics by the nuclear receptor REV-ERBalpha.
REFERENCE   5  (residues 1 to 657)
  AUTHORS   Alvarez-Fernandez L, Gomez-Gomez A, Haro N, Garcia-Lino AM, Alvarez
            AI, Pozo OJ and Merino G.
  TITLE     ABCG2 transporter plays a key role in the biodistribution of
            melatonin and its main metabolites
  JOURNAL   J Pineal Res 74 (2), e12849 (2023)
   PUBMED   36562106
  REMARK    GeneRIF: ABCG2 transporter plays a key role in the biodistribution
            of melatonin and its main metabolites.
REFERENCE   6  (residues 1 to 657)
  AUTHORS   Geschwind DH, Ou J, Easterday MC, Dougherty JD, Jackson RL, Chen Z,
            Antoine H, Terskikh A, Weissman IL, Nelson SF and Kornblum HI.
  TITLE     A genetic analysis of neural progenitor differentiation
  JOURNAL   Neuron 29 (2), 325-339 (2001)
   PUBMED   11239426
REFERENCE   7  (residues 1 to 657)
  AUTHORS   Jonker JW, Smit JW, Brinkhuis RF, Maliepaard M, Beijnen JH,
            Schellens JH and Schinkel AH.
  TITLE     Role of breast cancer resistance protein in the bioavailability and
            fetal penetration of topotecan
  JOURNAL   J Natl Cancer Inst 92 (20), 1651-1656 (2000)
   PUBMED   11036110
REFERENCE   8  (residues 1 to 657)
  AUTHORS   Schriml LM and Dean M.
  TITLE     Identification of 18 mouse ABC genes and characterization of the
            ABC superfamily in Mus musculus
  JOURNAL   Genomics 64 (1), 24-31 (2000)
   PUBMED   10708515
REFERENCE   9  (residues 1 to 657)
  AUTHORS   Allen JD, Brinkhuis RF, Wijnholds J and Schinkel AH.
  TITLE     The mouse Bcrp1/Mxr/Abcp gene: amplification and overexpression in
            cell lines selected for resistance to topotecan, mitoxantrone, or
            doxorubicin
  JOURNAL   Cancer Res 59 (17), 4237-4241 (1999)
   PUBMED   10485464
REFERENCE   10 (residues 1 to 657)
  AUTHORS   Allikmets R, Schriml LM, Hutchinson A, Romano-Spica V and Dean M.
  TITLE     A human placenta-specific ATP-binding cassette gene (ABCP) on
            chromosome 4q22 that is involved in multidrug resistance
  JOURNAL   Cancer Res 58 (23), 5337-5339 (1998)
   PUBMED   9850061
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121855.3 and AC121859.2.
            
            On Apr 20, 2020 this sequence version replaced XP_006506214.1.
            
            Summary: The membrane-associated protein encoded by this gene is
            included in the superfamily of ATP-binding cassette (ABC)
            transporters. ABC proteins transport various molecules across
            extra- and intra-cellular membranes. ABC genes are divided into
            seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,
            White). This protein is a member of the White subfamily.
            Alternatively referred to as a breast cancer resistance protein,
            the human protein functions as a xenobiotic transporter which may
            play a major role in multi-drug resistance. This protein likely
            serves as a cellular defense mechanism in response to mitoxantrone
            and anthracycline exposure. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189685.124441.1,
                                           SRR5189679.96595.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..657
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 27.82 cM"
     Protein         1..657
                     /product="broad substrate specificity ATP-binding cassette
                     transporter ABCG2"
                     /EC_number="7.6.2.2"
                     /note="mitoxantrone resistance protein 1; ATP-binding
                     cassette sub-family G member 2; breast cancer resistance
                     protein 1 homolog; urate exporter; ATP-binding cassette,
                     sub-family G (WHITE), member 2"
                     /calculated_mol_wt=72891
     Region          1..24
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TMS5.1)"
     Region          46..651
                     /region_name="3a01204"
                     /note="The Eye Pigment Precursor Transporter (EPP) Family
                     protein; TIGR00955"
                     /db_xref="CDD:273361"
     Site            394..414
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TMS5.1)"
     Site            429..449
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TMS5.1)"
     Site            478..498
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TMS5.1)"
     Site            507..527
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TMS5.1)"
     Site            536..556
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TMS5.1)"
     Site            596
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TMS5.1)"
     Site            600
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TMS5.1)"
     Site            633..653
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TMS5.1)"
     CDS             1..657
                     /gene="Abcg2"
                     /gene_synonym="ABC15; ABCP; BCRP; Bcrp1; MXR; MXR1"
                     /coded_by="NM_001355477.2:145..2118"
                     /db_xref="CCDS:CCDS20195.1"
                     /db_xref="GeneID:26357"
                     /db_xref="MGI:MGI:1347061"
ORIGIN      
        1 msssndhvlv pmsqrnnngl prmnsravrt laegdvlsfh hityrvkvks gflvrktvek
       61 eilsdingim kpglnailgp tgggksslld vlaarkdpkg lsgdvlinga pqpahfkccs
      121 gyvvqddvvm gtltvrenlq fsaalrlptt mknhekneri ntiikelgle kvadskvgtq
      181 firgisgger krtsigmeli tdpsilflde pttgldssta navllllkrm skqgrtiifs
      241 ihqprysifk lfdsltllas gklvfhgpaq kaleyfasag yhcepynnpa dffldvingd
      301 ssavmlnree qdneanktee pskgekpvie nlsefyinsa iygetkaeld qlpgaqekkg
      361 tsafkepvyv tsfchqlrwi arrsfknllg npqasvaqli vtvilgliig aiyfdlkyda
      421 agmqnragvl fflttnqcfs svsavelfvv ekklfiheyi sgyyrvssyf fgkvmsdllp
      481 mrflpsvift cilyfmlglk ktvdaffimm ftlimvayta ssmalaiatg qsvvsvatll
      541 mtiafvfmml fsgllvnlrt igpwlswlqy fsiprygfta lqyneflgqe fcpgfnvtdn
      601 stcvnsyaic tgneylinqg ielspwglwk nhvalacmii ifltiaylkl lflkkys
//
LOCUS       NP_001278098             903 aa            linear   ROD 09-OCT-2023
DEFINITION  nuclear factor of activated T-cells, cytoplasmic 2 isoform f [Mus
            musculus].
ACCESSION   NP_001278098 XP_006498953
VERSION     NP_001278098.1
DBSOURCE    REFSEQ: accession NM_001291169.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 903)
  AUTHORS   Fu Y, Wang J, Liu C, Liao K, Gao X, Tang R, Fan B, Hong Y, Xiao N,
            Xiao C and Liu WH.
  TITLE     Glycogen synthase kinase 3 controls T-cell exhaustion by regulating
            NFAT activation
  JOURNAL   Cell Mol Immunol 20 (10), 1127-1139 (2023)
   PUBMED   37553428
  REMARK    GeneRIF: Glycogen synthase kinase 3 controls T-cell exhaustion by
            regulating NFAT activation.
REFERENCE   2  (residues 1 to 903)
  AUTHORS   Wan X, Zhao S, Dai Y, Zhang J, Shen Y, Gong L and Le Q.
  TITLE     WNT16b promotes the proliferation and self-renewal of human limbal
            epithelial stem/progenitor cells via activating the
            calcium/calcineurin A/NFATC2 pathway
  JOURNAL   Cell Prolif 56 (10), e13460 (2023)
   PUBMED   36974338
  REMARK    GeneRIF: WNT16b promotes the proliferation and self-renewal of
            human limbal epithelial stem/progenitor cells via activating the
            calcium/calcineurin A/NFATC2 pathway.
REFERENCE   3  (residues 1 to 903)
  AUTHORS   Jiang F, Guo Y, Hu L, Zhang M, Meng J, Si Y and Shi H.
  TITLE     Role of nuclear factor of activated T Cells-1 in Sepsis-induced
            behavioral deficits in mice
  JOURNAL   Brain Res 1806, 148299 (2023)
   PUBMED   36842570
REFERENCE   4  (residues 1 to 903)
  AUTHORS   Nagai J, Lin J and Boyce JA.
  TITLE     Macrophage P2Y6 Receptor Signaling Selectively Activates NFATC2 and
            Suppresses Allergic Lung Inflammation
  JOURNAL   J Immunol 209 (12), 2293-2303 (2022)
   PUBMED   36307120
  REMARK    GeneRIF: Macrophage P2Y6 Receptor Signaling Selectively Activates
            NFATC2 and Suppresses Allergic Lung Inflammation.
REFERENCE   5  (residues 1 to 903)
  AUTHORS   Zhu L, Zhou X, Gu M, Kim J, Li Y, Ko CJ, Xie X, Gao T, Cheng X and
            Sun SC.
  TITLE     Dapl1 controls NFATc2 activation to regulate CD8+ T cell exhaustion
            and responses in chronic infection and cancer
  JOURNAL   Nat Cell Biol 24 (7), 1165-1176 (2022)
   PUBMED   35773432
REFERENCE   6  (residues 1 to 903)
  AUTHORS   Vihma H, Pruunsild P and Timmusk T.
  TITLE     Alternative splicing and expression of human and mouse NFAT genes
  JOURNAL   Genomics 92 (5), 279-291 (2008)
   PUBMED   18675896
REFERENCE   7  (residues 1 to 903)
  AUTHORS   Ho SN, Thomas DJ, Timmerman LA, Li X, Francke U and Crabtree GR.
  TITLE     NFATc3, a lymphoid-specific NFATc family member that is
            calcium-regulated and exhibits distinct DNA binding specificity
  JOURNAL   J Biol Chem 270 (34), 19898-19907 (1995)
   PUBMED   7650004
REFERENCE   8  (residues 1 to 903)
  AUTHORS   Jain J, Burgeon E, Badalian TM, Hogan PG and Rao A.
  TITLE     A similar DNA-binding motif in NFAT family proteins and the Rel
            homology region
  JOURNAL   J Biol Chem 270 (8), 4138-4145 (1995)
   PUBMED   7876165
REFERENCE   9  (residues 1 to 903)
  AUTHORS   Li X, Ho SN, Luna J, Giacalone J, Thomas DJ, Timmerman LA, Crabtree
            GR and Francke U.
  TITLE     Cloning and chromosomal localization of the human and murine genes
            for the T-cell transcription factors NFATc and NFATp
  JOURNAL   Cytogenet Cell Genet 68 (3-4), 185-191 (1995)
   PUBMED   7842733
REFERENCE   10 (residues 1 to 903)
  AUTHORS   Ho AM, Jain J, Rao A and Hogan PG.
  TITLE     Expression of the transcription factor NFATp in a neuronal cell
            line and in the murine nervous system
  JOURNAL   J Biol Chem 269 (45), 28181-28186 (1994)
   PUBMED   7961754
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK044489.1, EU887581.1 and BP757417.1.
            
            On Mar 27, 2014 this sequence version replaced XP_006498953.1.
            
            Transcript Variant: This variant (6, also known as IA-deltaII-Xa)
            contains an alternate 5' terminal exon, and it thus differs in the
            5' UTR and 5' coding region, and it also contains an additional
            exon that results in an alternate 3' coding region and 3' UTR,
            compared to variant 1. The encoded isoform (f) has distinct N- and
            C-termini and is shorter than isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU887581.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..903
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 88.91 cM"
     Protein         1..903
                     /product="nuclear factor of activated T-cells, cytoplasmic
                     2 isoform f"
                     /note="nuclear factor of activated T-cells, cytoplasmic 2;
                     NFAT pre-existing subunit; T-cell transcription factor
                     NFAT1"
                     /calculated_mol_wt=97487
     Region          380..554
                     /region_name="RHD-n_NFAT"
                     /note="N-terminal sub-domain of the Rel homology domain
                     (RHD) of nuclear factor of activated T-cells (NFAT)
                     proteins; cd07881"
                     /db_xref="CDD:143641"
     Site            order(403,406,408..409,411..413,461,502,504..505,519..520,
                     522,553)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143641"
     Region          559..659
                     /region_name="IPT_NFAT"
                     /note="IPT domain of the NFAT family of transcription
                     factors. NFAT transcription complexes are a target of
                     calcineurin, a calcium dependent phosphatase, and activate
                     genes mainly involved in cell-cell-interaction; cd01178"
                     /db_xref="CDD:238583"
     Site            order(583,647)
                     /site_type="DNA binding"
                     /note="DNA binding sites [nucleotide binding]"
                     /db_xref="CDD:238583"
     CDS             1..903
                     /gene="Nfatc2"
                     /gene_synonym="NF-ATc2; NF-ATp; NFAT1; NFAT1-D; Nfatp"
                     /coded_by="NM_001291169.1:120..2831"
                     /note="isoform f is encoded by transcript variant 6"
                     /db_xref="GeneID:18019"
                     /db_xref="MGI:MGI:102463"
ORIGIN      
        1 mqrpalrrpg prqplrtmgs adreepiahk aisspsglay pddvldyglk pcnplaslsg
       61 eppgrfgepd sigfqnflsp vkpagasgps prieitpshe lmqaggalrg rdaglspeqp
      121 alalagvaas prftlpvpgy egyreplcls passgssasf isdtfspyts pcvspnnagp
      181 ddlcpqfqni pahysprtsp imsprtslae dsclgrhspv prpasrsssp gakrrhscae
      241 alvaplpaas pqrsrspspq psphvalqdd sipagyppta gsavlmdaln tlatdspcgi
      301 pskiwktspd ptpvstapsk aglarhiypt veflgpceqe errnsapesi llvpptwpkq
      361 lvpaipicsi pvtaslpple wplsnqsgsy elrievqpkp hhrahyeteg srgavkaptg
      421 ghpvvqlhgy menkplglqi figtaderil kphafyqvhr itgktvttts yekivgntkv
      481 leiplepknn mratidcagi lklrnadiel rkgetdigrk ntrvrlvfrv hvpepsgriv
      541 slqaasnpie csqrsahelp mverqdmdsc lvyggqqmil tgqnftaesk vvfmekttdg
      601 qqiwemeatv dkdksqpnml fveipeyrnk hirvpvkvnf yvingkrkrs qpqhftyhpv
      661 paiktepsde yepslicspa hgglgsqpyy pqhpmlaesp sclvatmapc qqfrsglssp
      721 daryqqqspa aalyqrsksl spgllgyqqp sllaaplgla dahrsvlvha gsqgqgqgst
      781 lphtssasqq aspvihyspt nqqlrggghq efqhimycen fgpssarpgp ppinqgqrls
      841 pgayptviqq qtapsqraak ngpsdqkeal ptgvtvkqeq nldqtyldde lidthlswiq
      901 nil
//
LOCUS       NP_001390653             736 aa            linear   ROD 09-OCT-2023
DEFINITION  transcriptional repressor CTCF isoform 1 [Mus musculus].
ACCESSION   NP_001390653 XP_006530711
VERSION     NP_001390653.1
DBSOURCE    REFSEQ: accession NM_001403724.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 736)
  AUTHORS   Hewitt SC, Gruzdev A, Willson CJ, Wu SP, Lydon JP, Galjart N and
            DeMayo FJ.
  TITLE     Chromatin architectural factor CTCF is essential for
            progesterone-dependent uterine maturation
  JOURNAL   FASEB J 37 (8), e23103 (2023)
   PUBMED   37489832
  REMARK    GeneRIF: Chromatin architectural factor CTCF is essential for
            progesterone-dependent uterine maturation.
REFERENCE   2  (residues 1 to 736)
  AUTHORS   Smits WK, Vermeulen C, Hagelaar R, Kimura S, Vroegindeweij EM,
            Buijs-Gladdines JGCAM, van de Geer E, Verstegen MJAM, Splinter E,
            van Reijmersdal SV, Buijs A, Galjart N, van Eyndhoven W, van Min M,
            Kuiper R, Kemmeren P, Mullighan CG, de Laat W and Meijerink JPP.
  TITLE     Elevated enhancer-oncogene contacts and higher oncogene expression
            levels by recurrent CTCF inactivating mutations in acute T cell
            leukemia
  JOURNAL   Cell Rep 42 (4), 112373 (2023)
   PUBMED   37060567
REFERENCE   3  (residues 1 to 736)
  AUTHORS   Wang B, Ji L and Bian Q.
  TITLE     SATB1 regulates 3D genome architecture in T cells by constraining
            chromatin interactions surrounding CTCF-binding sites
  JOURNAL   Cell Rep 42 (4), 112323 (2023)
   PUBMED   37000624
  REMARK    GeneRIF: SATB1 regulates 3D genome architecture in T cells by
            constraining chromatin interactions surrounding CTCF-binding sites.
REFERENCE   4  (residues 1 to 736)
  AUTHORS   Marina-Zarate E, Rodriguez-Ronchel A, Gomez MJ, Sanchez-Cabo F and
            Ramiro AR.
  TITLE     Low-affinity CTCF binding drives transcriptional regulation whereas
            high-affinity binding encompasses architectural functions
  JOURNAL   iScience 26 (3), 106106 (2023)
   PUBMED   36852270
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 736)
  AUTHORS   Hsieh TS, Cattoglio C, Slobodyanyuk E, Hansen AS, Darzacq X and
            Tjian R.
  TITLE     Enhancer-promoter interactions and transcription are largely
            maintained upon acute loss of CTCF, cohesin, WAPL or YY1
  JOURNAL   Nat Genet 54 (12), 1919-1932 (2022)
   PUBMED   36471071
  REMARK    GeneRIF: Enhancer-promoter interactions and transcription are
            largely maintained upon acute loss of CTCF, cohesin, WAPL or YY1.
REFERENCE   6  (residues 1 to 736)
  AUTHORS   Farrell CM, West AG and Felsenfeld G.
  TITLE     Conserved CTCF insulator elements flank the mouse and human
            beta-globin loci
  JOURNAL   Mol Cell Biol 22 (11), 3820-3831 (2002)
   PUBMED   11997516
  REMARK    GeneRIF: Conserved CTCF insulator elements flank the mouse and
            human beta-globin loci.
REFERENCE   7  (residues 1 to 736)
  AUTHORS   Burke LJ, Hollemann T, Pieler T and Renkawitz R.
  TITLE     Molecular cloning and expression of the chromatin insulator protein
            CTCF in Xenopus laevis
  JOURNAL   Mech Dev 113 (1), 95-98 (2002)
   PUBMED   11900981
REFERENCE   8  (residues 1 to 736)
  AUTHORS   Chao W, Huynh KD, Spencer RJ, Davidow LS and Lee JT.
  TITLE     CTCF, a candidate trans-acting factor for X-inactivation choice
  JOURNAL   Science 295 (5553), 345-347 (2002)
   PUBMED   11743158
  REMARK    GeneRIF: It's proposed that Tsix and CTCF together establish a
            regulatable epigenetic switch for X-inactivation.
REFERENCE   9  (residues 1 to 736)
  AUTHORS   Lutz M, Burke LJ, Barreto G, Goeman F, Greb H, Arnold R,
            Schultheiss H, Brehm A, Kouzarides T, Lobanenkov V and Renkawitz R.
  TITLE     Transcriptional repression by the insulator protein CTCF involves
            histone deacetylases
  JOURNAL   Nucleic Acids Res 28 (8), 1707-1713 (2000)
   PUBMED   10734189
REFERENCE   10 (residues 1 to 736)
  AUTHORS   Filippova GN, Fagerlie S, Klenova EM, Myers C, Dehner Y, Goodwin G,
            Neiman PE, Collins SJ and Lobanenkov VV.
  TITLE     An exceptionally conserved transcriptional repressor, CTCF, employs
            different combinations of zinc fingers to bind diverged promoter
            sequences of avian and mammalian c-myc oncogenes
  JOURNAL   Mol Cell Biol 16 (6), 2802-2813 (1996)
   PUBMED   8649389
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127419.3 and AC152826.2.
            
            On Apr 4, 2022 this sequence version replaced XP_006530711.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13948564.4200465.1,
                                           SRR13422600.150052.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..736
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.04 cM"
     Protein         1..736
                     /product="transcriptional repressor CTCF isoform 1"
                     /note="transcriptional repressor CTCF; CTCFL paralog;
                     11-zinc finger protein"
                     /calculated_mol_wt=83615
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          180..211
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61164.2)"
     Region          266..289
                     /region_name="zf-H2C2_5"
                     /note="C2H2-type zinc-finger domain; pfam13909"
                     /db_xref="CDD:404746"
     Region          268..288
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(273,275,277,279..280,283..284,287,301,303,307..308,
                     311..312,315,329,331,333,335..336,339..340,346)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          280..305
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:433230"
     Site            289
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          296..316
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          309..333
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:433230"
     Site            317
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          324..347
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          351..375
                     /region_name="zf-H2C2_5"
                     /note="C2H2-type zinc-finger domain; pfam13909"
                     /db_xref="CDD:404746"
     Region          353..373
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          <366..500
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Site            374
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          381..401
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            402
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          409..426
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          439..457
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          469..489
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(474,476,478,480..481,484..485,488,502,504,508..509,
                     512..513,516,530,532,534,536..537,540..541,545)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          497..517
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          509..534
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:433230"
     Region          525..546
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          557..573
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          573..686
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61164.2)"
     Site            609
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Site            610
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Site            612
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          699..726
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61164.2)"
     CDS             1..736
                     /gene="Ctcf"
                     /coded_by="NM_001403724.1:758..2968"
                     /note="isoform 1 is encoded by transcript variant 4"
                     /db_xref="GeneID:13018"
                     /db_xref="MGI:MGI:109447"
ORIGIN      
        1 megeaveaiv eesetfikgk erktyqrrre ggqeedachl pqnqtdggev vqdvnssvqm
       61 vmmeqldptl lqmktevmeg tvapeaeaav ddtqiitlqv vnmeeqpini gelqlvqvpv
      121 pvtvpvatts veelqgayen evskeglaes epmichtlpl pegfqvvkvg angevetleq
      181 gelppqedss wqkdpdyqpp akktkktkks klryteegkd vdvsvydfee eqqegllsev
      241 naekvvgnmk ppkptkikkk gvkktfqcel csytcprrsn ldrhmkshtd erphkchlcg
      301 rafrtvtllr nhlnthtgtr phkcpdcdma fvtsgelvrh rrykhthekp fkcsmcdyas
      361 vevsklkrhi rshtgerpfq cslcsyasrd tyklkrhmrt hsgekpyecy icharftqsg
      421 tmkmhilqkh tenvakfhcp hcdtviarks dlgvhlrkqh syieqgkkcr ycdavfhery
      481 aliqhqkshk nekrfkcdqc dyacrqerhm imhkrthtge kpyacshcdk tfrqkqlldm
      541 hfkryhdpnf vpaafvcskc gktftrrntm arhadncagp dgvegengge tkkskrgrkr
      601 kmrskkedss dseenaepdl ddneeeeepa veiepepepq pqpppppqpv apapppakkr
      661 rgrppgrtnq pkqnqptaii qvedqntgai eniivevkke pdaepaegee eeaqaattda
      721 pngdltpemi lsmmdr
//
LOCUS       NP_001394509             426 aa            linear   ROD 09-OCT-2023
DEFINITION  mitogen-activated protein kinase 10 isoform 4 [Mus musculus].
ACCESSION   NP_001394509 XP_017176378
VERSION     NP_001394509.1
DBSOURCE    REFSEQ: accession NM_001407580.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 426)
  AUTHORS   Priego M, Noriega L, Kalinin S, Hoffman LM, Feinstein DL and
            Morfini G.
  TITLE     Genetic deletion of c-Jun amino-terminal kinase 3 (JNK3) modestly
            increases disease severity in a mouse model of multiple sclerosis
  JOURNAL   J Neuroimmunol 382, 578152 (2023)
   PUBMED   37454525
  REMARK    GeneRIF: Genetic deletion of c-Jun amino-terminal kinase 3 (JNK3)
            modestly increases disease severity in a mouse model of multiple
            sclerosis.
REFERENCE   2  (residues 1 to 426)
  AUTHORS   Liu F, Deng Y, Zhao Y, Li Z, Gao J, Zhang Y, Yang X, Liu Y and Xia
            Y.
  TITLE     Time series RNA-seq analysis identifies MAPK10 as a critical gene
            in diabetes mellitus-induced atrial fibrillation in mice
  JOURNAL   J Mol Cell Cardiol 168, 70-82 (2022)
   PUBMED   35489387
  REMARK    GeneRIF: Time series RNA-seq analysis identifies MAPK10 as a
            critical gene in diabetes mellitus-induced atrial fibrillation in
            mice.
REFERENCE   3  (residues 1 to 426)
  AUTHORS   Cunningham JG, Scripter JD, Nti SA and Tucker ES.
  TITLE     Early construction of the thalamocortical axon pathway requires
            c-Jun N-terminal kinase signaling within the ventral forebrain
  JOURNAL   Dev Dyn 251 (3), 459-480 (2022)
   PUBMED   34494344
REFERENCE   4  (residues 1 to 426)
  AUTHORS   Goodwani S, Fernandez C, Acton PJ, Buggia-Prevot V, McReynolds ML,
            Ma J, Hu CH, Hamby ME, Jiang Y, Le K, Soth MJ, Jones P and Ray WJ.
  TITLE     Dual Leucine Zipper Kinase Is Constitutively Active in the Adult
            Mouse Brain and Has Both Stress-Induced and Homeostatic Functions
  JOURNAL   Int J Mol Sci 21 (14), 4849 (2020)
   PUBMED   32659913
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 426)
  AUTHORS   Loughran G, Chou MY, Ivanov IP, Jungreis I, Kellis M, Kiran AM,
            Baranov PV and Atkins JF.
  TITLE     Evidence of efficient stop codon readthrough in four mammalian
            genes
  JOURNAL   Nucleic Acids Res 42 (14), 8928-8938 (2014)
   PUBMED   25013167
REFERENCE   6  (residues 1 to 426)
  AUTHORS   Beier H and Grimm M.
  TITLE     Misreading of termination codons in eukaryotes by natural nonsense
            suppressor tRNAs
  JOURNAL   Nucleic Acids Res 29 (23), 4767-4782 (2001)
   PUBMED   11726686
  REMARK    Review article
REFERENCE   7  (residues 1 to 426)
  AUTHORS   Yang DD, Kuan CY, Whitmarsh AJ, Rincon M, Zheng TS, Davis RJ, Rakic
            P and Flavell RA.
  TITLE     Absence of excitotoxicity-induced apoptosis in the hippocampus of
            mice lacking the Jnk3 gene
  JOURNAL   Nature 389 (6653), 865-870 (1997)
   PUBMED   9349820
REFERENCE   8  (residues 1 to 426)
  AUTHORS   Casanova E, Garate C, Ovalle S, Calvo P and Chinchetru MA.
  TITLE     Identification of four splice variants of the mouse
            stress-activated protein kinase JNK/SAPK alpha-isoform
  JOURNAL   Neuroreport 7 (7), 1320-1324 (1996)
   PUBMED   8817558
REFERENCE   9  (residues 1 to 426)
  AUTHORS   Martin JH, Mohit AA and Miller CA.
  TITLE     Developmental expression in the mouse nervous system of the p493F12
            SAP kinase
  JOURNAL   Brain Res Mol Brain Res 35 (1-2), 47-57 (1996)
   PUBMED   8717339
REFERENCE   10 (residues 1 to 426)
  AUTHORS   Suzuki J, Yoshida S, Chen ZL, Momota Y, Kato K, Hirata A and
            Shiosaka S.
  TITLE     Ontogeny of neuropsin mRNA expression in the mouse brain
  JOURNAL   Neurosci Res 23 (4), 345-351 (1995)
   PUBMED   8602273
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC160244.11, AC123664.15,
            AC137121.9 and AC125252.7.
            
            On Jun 6, 2022 this sequence version replaced XP_017176378.1.
            
            Summary: The protein encoded by this gene is a member of the MAP
            kinase family. MAP kinases act as integration points for multiple
            biochemical signals, and thus are involved in a wide variety of
            cellular processes, such as proliferation, differentiation,
            transcription regulation and development. This kinase is
            specifically expressed in a subset of neurons in the nervous system
            and is activated by threonine and tyrosine phosphorylation.
            Targeted deletion of this gene in mice suggests that it may have a
            role in stress-induced neuronal apoptosis. Alternatively spliced
            transcript variants encoding different isoforms have been found for
            this gene. A recent study provided evidence for translational
            readthrough in this gene, and expression of an additional
            C-terminally extended isoform via the use of an alternative
            in-frame translation termination codon. [provided by RefSeq, Dec
            2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784644.895398.1,
                                           SRR17784645.974247.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849376 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..426
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 49.61 cM"
     Protein         1..426
                     /product="mitogen-activated protein kinase 10 isoform 4"
                     /EC_number="2.7.11.24"
                     /note="JNK3 beta1 protein kinase; JNK3 beta2 protein
                     kinase; MAP kinase 10; MAP kinase p49 3F12; c-Jun
                     N-terminal kinase 3; stress-activated protein kinase JNK3;
                     SAPK/Erk/kinase 2"
                     /calculated_mol_wt=47767
     Region          25..360
                     /region_name="STKc_JNK"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     c-Jun N-terminal Kinase; cd07850"
                     /db_xref="CDD:270840"
     Site            order(32..38,40,53,55,72,86,108..114,116..117,151,153,
                     155..156,158,168..169,172,183,185..188,190,227)
                     /site_type="active"
                     /db_xref="CDD:270840"
     Site            order(32..38,40,53,55,86,108..114,158,168)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270840"
     Site            order(72,116,151,153,172,183,185..188,190,227)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270840"
     Site            order(112,118,127,130,159..163,323..324,326,329)
                     /site_type="other"
                     /note="KIM docking site [polypeptide binding]"
                     /db_xref="CDD:270840"
     Site            order(168..178,182..190)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270840"
     CDS             1..426
                     /gene="Mapk10"
                     /gene_synonym="C230008H04Rik; JNK3; JNK3B1; JNK3B2;
                     p493F12; p54bSAPK; SAPK(beta); Serk2"
                     /coded_by="NM_001407580.1:658..1938"
                     /note="isoform 4 is encoded by transcript variant 15"
                     /db_xref="GeneID:26414"
                     /db_xref="MGI:MGI:1346863"
ORIGIN      
        1 mskskvdnqf ysvevgdstf tvlkryqnlk pigsgaqgiv caaydavldr nvaikklsrp
       61 fqnqthakra yrelvlmkcv nhkniislln vftpqktlee fqdvylvmel mdanlcqviq
      121 meldhermsy llyqmlcgik hlhsagiihr dlkpsnivvk sdctlkildf glartagtsf
      181 mmtpyvvtry yrapevilgm gykenvdlws vgcimgemvk gtvlfpgtdh idqwnkvieq
      241 lgtpcpefmk klqptvrnyv enrpkyaglt fpklfpdslf padsehnklk asqardllsk
      301 mlvidpakri svddalqhpy invwydpaev eapppqiydk qlderehtie ewkeliykev
      361 mnseektkng vvkgqpspsg aavnsseslp psssvndiss mstdqtlasd tdssleasag
      421 plgccr
//
LOCUS       NP_001313280            1657 aa            linear   ROD 09-OCT-2023
DEFINITION  A disintegrin and metalloproteinase with thrombospondin motifs 7
            isoform 4 preproprotein [Mus musculus].
ACCESSION   NP_001313280 XP_006510821
VERSION     NP_001313280.1
DBSOURCE    REFSEQ: accession NM_001326351.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1657)
  AUTHORS   Sharifi MA, Wierer M, Dang TA, Milic J, Moggio A, Sachs N, von
            Scheidt M, Hinterdobler J, Muller P, Werner J, Stiller B,
            Aherrahrou Z, Erdmann J, Zaliani A, Graettinger M, Reinshagen J,
            Gul S, Gribbon P, Maegdefessel L, Bernhagen J, Sager HB, Mann M,
            Schunkert H and Kessler T.
  TITLE     ADAMTS-7 Modulates Atherosclerotic Plaque Formation by Degradation
            of TIMP-1
  JOURNAL   Circ Res 133 (8), 674-686 (2023)
   PUBMED   37675562
  REMARK    GeneRIF: ADAMTS-7 Modulates Atherosclerotic Plaque Formation by
            Degradation of TIMP-1.
REFERENCE   2  (residues 1 to 1657)
  AUTHORS   Gong Z, Huang J, Wang D, Yang S, Ma Z, Fu Y, Ma Q and Kong W.
  TITLE     ADAMTS-7 deficiency attenuates thoracic aortic aneurysm and
            dissection in mice
  JOURNAL   J Mol Med (Berl) 101 (3), 237-248 (2023)
   PUBMED   36662289
  REMARK    GeneRIF: ADAMTS-7 deficiency attenuates thoracic aortic aneurysm
            and dissection in mice.
REFERENCE   3  (residues 1 to 1657)
  AUTHORS   Ma Z, Mao C, Jia Y, Yu F, Xu P, Tan Y, Zou QH, Zhou XJ, Kong W and
            Fu Y.
  TITLE     ADAMTS7-Mediated Complement Factor H Degradation Potentiates
            Complement Activation to Contributing to Renal Injuries
  JOURNAL   J Am Soc Nephrol 34 (2), 291-308 (2023)
   PUBMED   36735376
  REMARK    GeneRIF: ADAMTS7-Mediated Complement Factor H Degradation
            Potentiates Complement Activation to Contributing to Renal
            Injuries.
REFERENCE   4  (residues 1 to 1657)
  AUTHORS   Jaiswal AK and Mishra A.
  TITLE     ADAMTS7 Attenuates House Dust Mite-Induced Airway Inflammation and
            Th2 Immune Responses
  JOURNAL   Lung 200 (3), 305-313 (2022)
   PUBMED   35503474
  REMARK    GeneRIF: ADAMTS7 Attenuates House Dust Mite-Induced Airway
            Inflammation and Th2 Immune Responses.
REFERENCE   5  (residues 1 to 1657)
  AUTHORS   Mizoguchi T, MacDonald BT, Bhandary B, Popp NR, Laprise D, Arduini
            A, Lai D, Zhu QM, Xing Y, Kaushik VK, Kathiresan S and Ellinor PT.
  TITLE     Coronary Disease Association With ADAMTS7 Is Due to Protease
            Activity
  JOURNAL   Circ Res 129 (4), 458-470 (2021)
   PUBMED   34176299
REFERENCE   6  (residues 1 to 1657)
  AUTHORS   Lai Y, Bai X, Zhao Y, Tian Q, Liu B, Lin EA, Chen Y, Lee B,
            Appleton CT, Beier F, Yu XP and Liu CJ.
  TITLE     ADAMTS-7 forms a positive feedback loop with TNF-alpha in the
            pathogenesis of osteoarthritis
  JOURNAL   Ann Rheum Dis 73 (8), 1575-1584 (2014)
   PUBMED   23928557
  REMARK    GeneRIF: ADAMTS-7 and TNF-alpha form a positive feedback loop in
            the regulation of cartilage degradation and osteoarthritis
            progression.
REFERENCE   7  (residues 1 to 1657)
  AUTHORS   Du J, Takeuchi H, Leonhard-Melief C, Shroyer KR, Dlugosz M,
            Haltiwanger RS and Holdener BC.
  TITLE     O-fucosylation of thrombospondin type 1 repeats restricts
            epithelial to mesenchymal transition (EMT) and maintains epiblast
            pluripotency during mouse gastrulation
  JOURNAL   Dev Biol 346 (1), 25-38 (2010)
   PUBMED   20637190
REFERENCE   8  (residues 1 to 1657)
  AUTHORS   Bai XH, Wang DW, Kong L, Zhang Y, Luan Y, Kobayashi T, Kronenberg
            HM, Yu XP and Liu CJ.
  TITLE     ADAMTS-7, a direct target of PTHrP, adversely regulates
            endochondral bone growth by associating with and inactivating GEP
            growth factor
  JOURNAL   Mol Cell Biol 29 (15), 4201-4219 (2009)
   PUBMED   19487464
  REMARK    GeneRIF: Findings demonstrate that ADAMTS-7, a direct target of
            PTHrP signaling, negatively regulates endochondral bone formation
            by associating with and inactivating GEP chondrogenic growth
            factor.
REFERENCE   9  (residues 1 to 1657)
  AUTHORS   Somerville RP, Longpre JM, Apel ED, Lewis RM, Wang LW, Sanes JR,
            Leduc R and Apte SS.
  TITLE     ADAMTS7B, the full-length product of the ADAMTS7 gene, is a
            chondroitin sulfate proteoglycan containing a mucin domain
  JOURNAL   J Biol Chem 279 (34), 35159-35175 (2004)
   PUBMED   15192113
  REMARK    GeneRIF: ADAMTS7B has a domain organization with a total of eight
            thrombospondin type 1 repeats in its ancillary domain. Of these,
            seven are arranged in two distinct clusters that are separated by a
            mucin domain
REFERENCE   10 (residues 1 to 1657)
  AUTHORS   Hurskainen TL, Hirohata S, Seldin MF and Apte SS.
  TITLE     ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of
            zinc metalloproteases. General features and genomic distribution of
            the ADAM-TS family
  JOURNAL   J Biol Chem 274 (36), 25555-25563 (1999)
   PUBMED   10464288
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY347798.1, BC076575.1,
            CB246893.1, AC140392.3 and BC058991.1.
            
            On May 15, 2016 this sequence version replaced XP_006510821.1.
            
            Summary: This gene encodes a member of 'a disintegrin and
            metalloproteinase with thrombospondin motifs' (ADAMTS) family of
            multi-domain matrix-associated metalloendopeptidases that have
            diverse roles in tissue morphogenesis and pathophysiological
            remodeling, in inflammation and in vascular biology. The encoded
            preproprotein undergoes proteolytic processing to generate an
            active, zinc-dependent enzyme that degrades cartilage oligomeric
            matrix protein. The deficiency of the encoded protein decreases
            atherosclerosis in genetically hyperlipidemic mice and in response
            to vascular injury. Alternative splicing results in multiple
            transcript variants encoding different isoforms, some of which may
            undergo similar processing. [provided by RefSeq, May 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on the transcript AY551090.1. An
            unsupported intron in the 3' coding region of this transcript was
            replaced with sequence from the reference genome assembly.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223969.9220.1,
                                           SRR9219380.72908.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1657
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 47.46 cM"
     Protein         1..1657
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 7 isoform 4 preproprotein"
                     /EC_number="3.4.24.-"
                     /note="a disintegrin and metalloproteinase with
                     thrombospondin motifs 7; COMPase; a disintegrin-like and
                     metalloprotease (reprolysin type) with thrombospondin type
                     1 motif, 7; a disintegrin-like and metallopeptidase
                     (reprolysin type) with thrombospondin type 1 motif, 7"
                     /calculated_mol_wt=180212
     sig_peptide     1..20
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q68SA9.3)"
                     /calculated_mol_wt=2121
     Region          34..174
                     /region_name="Pep_M12B_propep"
                     /note="Reprolysin family propeptide; pfam01562"
                     /db_xref="CDD:426325"
     Site            84
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q68SA9.3)"
     Region          165..221
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q68SA9.3)"
     Region          192..199
                     /region_name="Cysteine switch. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q68SA9.3)"
     mat_peptide     221..1657
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 7. /id=PRO_0000348235"
                     /note="propagated from UniProtKB/Swiss-Prot (Q68SA9.3)"
                     /calculated_mol_wt=157959
     Region          226..434
                     /region_name="ZnMc_ADAMTS_like"
                     /note="Zinc-dependent metalloprotease, ADAMTS_like
                     subgroup. ADAMs (A Disintegrin And Metalloprotease) are
                     glycoproteins, which play roles in cell signaling, cell
                     fusion, and cell-cell interactions. This particular
                     subfamily represents domain architectures that...;
                     cd04273"
                     /db_xref="CDD:239801"
     Site            order(372..373,376,382)
                     /site_type="active"
                     /db_xref="CDD:239801"
     Region          449..513
                     /region_name="ADAM_CR_2"
                     /note="ADAM cysteine-rich domain; pfam17771"
                     /db_xref="CDD:436031"
     Region          526..578
                     /region_name="TSP1"
                     /note="Thrombospondin type 1 repeats; smart00209"
                     /db_xref="CDD:214559"
     Region          584..682
                     /region_name="ADAM_CR_3"
                     /note="ADAM cysteine-rich domain; pfam19236"
                     /db_xref="CDD:437068"
     Site            622
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q68SA9.3)"
     Region          683..794
                     /region_name="Spacer"
                     /note="propagated from UniProtKB/Swiss-Prot (Q68SA9.3)"
     Region          684..793
                     /region_name="ADAM_spacer1"
                     /note="ADAM-TS Spacer 1; pfam05986"
                     /db_xref="CDD:428708"
     Region          808..862
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:408800"
     Region          866..922
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:408800"
     Region          929..977
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:408800"
     Region          1009..1034
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q68SA9.3)"
     Region          <1065..1403
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          1073..1127
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q68SA9.3)"
     Region          1140..1237
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q68SA9.3)"
     Region          1283..1304
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q68SA9.3)"
     Region          1317..1384
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q68SA9.3)"
     Region          1386..1434
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:408800"
     Region          1437..1492
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:408800"
     Region          1495..1541
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:408800"
     Region          1544..1599
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:408800"
     CDS             1..1657
                     /gene="Adamts7"
                     /gene_synonym="ADAM-TS7; ADAMTS7B"
                     /coded_by="NM_001326351.1:268..5241"
                     /note="isoform 4 preproprotein is encoded by transcript
                     variant 4"
                     /db_xref="CCDS:CCDS85708.1"
                     /db_xref="GeneID:108153"
                     /db_xref="MGI:MGI:1347346"
ORIGIN      
        1 mhrgpsllli lcalasrvlg pasglvtegr agldivhpvr vdaggsflsy elwprvlrkr
       61 dvsttqassa fyqlqyqgre llfnlttnpy lmapgfvsei rrhstlghah iqtsvptchl
      121 lgdvqdpele ggfaaisacd glrgvfqlsn edyfiepldg vsaqpghaqp hvvykhqgsr
      181 kqaqqgdsrp sgtcgmqvpp dleqqrehwe qqqqkrrqqr svskekwvet lvvadskmve
      241 yhgqpqvesy vltimnmvag lfhdpsignp ihisivrlii ledeekdlki thhaeetlkn
      301 fcrwqknini kgddhpqhhd tailltrkdl casmnqpcet lglshvsglc hpqlscsvse
      361 dtgmplaftv ahelghsfgi qhdgtgndce sigkrpfims pqllydrgip ltwsrcsrey
      421 itrfldrgwg lclddrpskd vialpsvlpg vlydvnhqcr lqygshsayc edmddvchtl
      481 wcsvgttchs kldaavdgts cgknkwclkg ecvpegfqpe avdggwsgws awsdcsrscg
      541 vgvrsserqc tqpvpknrgk ycvgerkrsq lcnlpacppd rpsfrhtqcs qfdgmlykgk
      601 lhkwvpvpnd dnpcelhcrp snssnteklr davvdgtpcy qsrisrdicl ngicknvgcd
      661 fvidsgaeed rcgvcrgdgs tcqtvsrtfk etegqgyvdi glipagarei lieevaeaan
      721 flalrsedpd kyflnggwti qwngdyrvag ttftyarkgn wenltspgpt sepvwiqllf
      781 qeknpgvhyq ytiqrdshdq vrppefswhy gpwskctvtc gtgvqrqsly cmerqagvva
      841 eeycntlnrp derqrkcsee pcpprwwage wqpcsrscgp eglsrravfc irsmgldeqr
      901 alelsacehl prplaetpcn rhvicpstwg vgnwsqcsvt cgagirqrsv lcinntdvpc
      961 deaerpitet fcflqpcqyp myivdtgasg sgssspelfn evdfipnqla prpspasspk
     1021 pvsisnaide eeldppgpvf vddfyydynf infhedlsyg sfeephpdlv dnggwtapph
     1081 irptespsdt pvptagalga eaediqgsws pspllseasy sppgleqtsi nplanfltee
     1141 dtpmgapelg fpslpwppas vddmmtpvgp gnpdellvke deqsppstpw sdrnklstdg
     1201 nplghtspal pqspiptqps ppsisptqas pspdvvevst gwnaawdpvl eadlkpghge
     1261 lpstvevasp pllpmatvpg iwgrdsplep gtptfsspel ssqhlktltm pgtllltvpt
     1321 dlrspgpsgq pqtpnlegtq spgllptpar etqtnsskdp evqplqpsle edgdpadplp
     1381 arnaswqvgn wsqcsttcgl gaiwrlvscs sgndedctla srpqparhch lrpcaawrtg
     1441 nwskcsrncg ggsstrdvqc vdtrdlrplr pfhcqpgptk ppnrqlcgtq pclpwytssw
     1501 recseacggg eqqrlvtcpe pglceeslrp nnsrpcnthp ctqwvvgpwg qcsapcgggv
     1561 qrrlvrcvnt qtglaeedsd lcsheawpes srpcatedce lvepprcerd rlsfnfcetl
     1621 rllgrcqlpt iraqccrscp plsrgvpsrg hqrvarr
//
LOCUS       NP_001394517             390 aa            linear   ROD 09-OCT-2023
DEFINITION  mitogen-activated protein kinase 10 isoform 10 [Mus musculus].
ACCESSION   NP_001394517 XP_011247752
VERSION     NP_001394517.1
DBSOURCE    REFSEQ: accession NM_001407588.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 390)
  AUTHORS   Priego M, Noriega L, Kalinin S, Hoffman LM, Feinstein DL and
            Morfini G.
  TITLE     Genetic deletion of c-Jun amino-terminal kinase 3 (JNK3) modestly
            increases disease severity in a mouse model of multiple sclerosis
  JOURNAL   J Neuroimmunol 382, 578152 (2023)
   PUBMED   37454525
  REMARK    GeneRIF: Genetic deletion of c-Jun amino-terminal kinase 3 (JNK3)
            modestly increases disease severity in a mouse model of multiple
            sclerosis.
REFERENCE   2  (residues 1 to 390)
  AUTHORS   Liu F, Deng Y, Zhao Y, Li Z, Gao J, Zhang Y, Yang X, Liu Y and Xia
            Y.
  TITLE     Time series RNA-seq analysis identifies MAPK10 as a critical gene
            in diabetes mellitus-induced atrial fibrillation in mice
  JOURNAL   J Mol Cell Cardiol 168, 70-82 (2022)
   PUBMED   35489387
  REMARK    GeneRIF: Time series RNA-seq analysis identifies MAPK10 as a
            critical gene in diabetes mellitus-induced atrial fibrillation in
            mice.
REFERENCE   3  (residues 1 to 390)
  AUTHORS   Cunningham JG, Scripter JD, Nti SA and Tucker ES.
  TITLE     Early construction of the thalamocortical axon pathway requires
            c-Jun N-terminal kinase signaling within the ventral forebrain
  JOURNAL   Dev Dyn 251 (3), 459-480 (2022)
   PUBMED   34494344
REFERENCE   4  (residues 1 to 390)
  AUTHORS   Goodwani S, Fernandez C, Acton PJ, Buggia-Prevot V, McReynolds ML,
            Ma J, Hu CH, Hamby ME, Jiang Y, Le K, Soth MJ, Jones P and Ray WJ.
  TITLE     Dual Leucine Zipper Kinase Is Constitutively Active in the Adult
            Mouse Brain and Has Both Stress-Induced and Homeostatic Functions
  JOURNAL   Int J Mol Sci 21 (14), 4849 (2020)
   PUBMED   32659913
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 390)
  AUTHORS   Loughran G, Chou MY, Ivanov IP, Jungreis I, Kellis M, Kiran AM,
            Baranov PV and Atkins JF.
  TITLE     Evidence of efficient stop codon readthrough in four mammalian
            genes
  JOURNAL   Nucleic Acids Res 42 (14), 8928-8938 (2014)
   PUBMED   25013167
REFERENCE   6  (residues 1 to 390)
  AUTHORS   Beier H and Grimm M.
  TITLE     Misreading of termination codons in eukaryotes by natural nonsense
            suppressor tRNAs
  JOURNAL   Nucleic Acids Res 29 (23), 4767-4782 (2001)
   PUBMED   11726686
  REMARK    Review article
REFERENCE   7  (residues 1 to 390)
  AUTHORS   Yang DD, Kuan CY, Whitmarsh AJ, Rincon M, Zheng TS, Davis RJ, Rakic
            P and Flavell RA.
  TITLE     Absence of excitotoxicity-induced apoptosis in the hippocampus of
            mice lacking the Jnk3 gene
  JOURNAL   Nature 389 (6653), 865-870 (1997)
   PUBMED   9349820
REFERENCE   8  (residues 1 to 390)
  AUTHORS   Casanova E, Garate C, Ovalle S, Calvo P and Chinchetru MA.
  TITLE     Identification of four splice variants of the mouse
            stress-activated protein kinase JNK/SAPK alpha-isoform
  JOURNAL   Neuroreport 7 (7), 1320-1324 (1996)
   PUBMED   8817558
REFERENCE   9  (residues 1 to 390)
  AUTHORS   Martin JH, Mohit AA and Miller CA.
  TITLE     Developmental expression in the mouse nervous system of the p493F12
            SAP kinase
  JOURNAL   Brain Res Mol Brain Res 35 (1-2), 47-57 (1996)
   PUBMED   8717339
REFERENCE   10 (residues 1 to 390)
  AUTHORS   Suzuki J, Yoshida S, Chen ZL, Momota Y, Kato K, Hirata A and
            Shiosaka S.
  TITLE     Ontogeny of neuropsin mRNA expression in the mouse brain
  JOURNAL   Neurosci Res 23 (4), 345-351 (1995)
   PUBMED   8602273
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC123664.15, AC137121.9 and
            AC125252.7.
            
            On Jun 6, 2022 this sequence version replaced XP_011247752.1.
            
            Summary: The protein encoded by this gene is a member of the MAP
            kinase family. MAP kinases act as integration points for multiple
            biochemical signals, and thus are involved in a wide variety of
            cellular processes, such as proliferation, differentiation,
            transcription regulation and development. This kinase is
            specifically expressed in a subset of neurons in the nervous system
            and is activated by threonine and tyrosine phosphorylation.
            Targeted deletion of this gene in mice suggests that it may have a
            role in stress-induced neuronal apoptosis. Alternatively spliced
            transcript variants encoding different isoforms have been found for
            this gene. A recent study provided evidence for translational
            readthrough in this gene, and expression of an additional
            C-terminally extended isoform via the use of an alternative
            in-frame translation termination codon. [provided by RefSeq, Dec
            2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189685.206118.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849376 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..390
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 49.61 cM"
     Protein         1..390
                     /product="mitogen-activated protein kinase 10 isoform 10"
                     /EC_number="2.7.11.24"
                     /note="JNK3 beta1 protein kinase; JNK3 beta2 protein
                     kinase; MAP kinase 10; MAP kinase p49 3F12; c-Jun
                     N-terminal kinase 3; stress-activated protein kinase JNK3;
                     SAPK/Erk/kinase 2"
                     /calculated_mol_wt=44139
     Region          6..324
                     /region_name="STKc_JNK"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     c-Jun N-terminal Kinase; cd07850"
                     /db_xref="CDD:270840"
     Site            order(36,80,115,117,136,147,149..152,154,191)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270840"
     Site            order(76,82,91,94,123..127,287..288,290,293)
                     /site_type="other"
                     /note="KIM docking site [polypeptide binding]"
                     /db_xref="CDD:270840"
     Site            order(132..142,146..154)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270840"
     CDS             1..390
                     /gene="Mapk10"
                     /gene_synonym="C230008H04Rik; JNK3; JNK3B1; JNK3B2;
                     p493F12; p54bSAPK; SAPK(beta); Serk2"
                     /coded_by="NM_001407588.1:226..1398"
                     /note="isoform 10 is encoded by transcript variant 18"
                     /db_xref="GeneID:26414"
                     /db_xref="MGI:MGI:1346863"
ORIGIN      
        1 mntwsaayda vldrnvaikk lsrpfqnqth akrayrelvl mkcvnhknii sllnvftpqk
       61 tleefqdvyl vmelmdanlc qviqmeldhe rmsyllyqml cgikhlhsag iihrdlkpsn
      121 ivvksdctlk ildfglarta gtsfmmtpyv vtryyrapev ilgmgykenv diwsvgcimg
      181 emvrhkilfp grdyidqwnk vieqlgtpcp efmkklqptv rnyvenrpky agltfpklfp
      241 dslfpadseh nklkasqard llskmlvidp akrisvddal qhpyinvwyd paeveapppq
      301 iydkqldere htieewkeli ykevmnseek tkngvvkgqp spsgaavnss eslppsssvn
      361 dissmstdqt lasdtdssle asagplgccr
//
LOCUS       NP_001271339              91 aa            linear   ROD 09-OCT-2023
DEFINITION  bcl-2-like protein 11 isoform 4 [Mus musculus].
ACCESSION   NP_001271339
VERSION     NP_001271339.2
DBSOURCE    REFSEQ: accession NM_001284410.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 91)
  AUTHORS   Jiang M, Wang XB and Jiang S.
  TITLE     circ_0000018 downregulation peripherally ameliorates
            neuroprotection against acute ischemic stroke through the
            miR-871/BCL2L11 axis
  JOURNAL   Mol Med Rep 28 (5) (2023)
   PUBMED   37772397
  REMARK    GeneRIF: circ_0000018 downregulation peripherally ameliorates
            neuroprotection against acute ischemic stroke through the
            miR-871/BCL2L11 axis.
REFERENCE   2  (residues 1 to 91)
  AUTHORS   Lu Y, Tang K, Wang S, Tian Z, Fan Y, Li B, Wang M, Zhao J and Xie
            J.
  TITLE     Dach1 deficiency drives alveolar epithelium apoptosis in pulmonary
            fibrosis via modulating C-Jun/Bim activity
  JOURNAL   Transl Res 257, 54-65 (2023)
   PUBMED   36754276
  REMARK    GeneRIF: Dach1 deficiency drives alveolar epithelium apoptosis in
            pulmonary fibrosis via modulating C-Jun/Bim activity.
REFERENCE   3  (residues 1 to 91)
  AUTHORS   Nguyen HV, Vandenberg CJ, Robati MR, Ng AP and Cory S.
  TITLE     MNT suppresses T cell apoptosis via BIM and is critical for T
            lymphomagenesis
  JOURNAL   Cell Death Differ 30 (4), 1018-1032 (2023)
   PUBMED   36755068
  REMARK    GeneRIF: MNT suppresses T cell apoptosis via BIM and is critical
            for T lymphomagenesis.
REFERENCE   4  (residues 1 to 91)
  AUTHORS   Chen H, Bai Y, Kobayashi M, Xiao S, Cai W, Barajas S, Chen S, Miao
            J, Meke FN, Vemula S, Ropa JP, Croop JM, Boswell HS, Wan J, Jia Y,
            Liu H, Li LS, Altman JK, Eklund EA, Ji P, Tong W, Band H, Huang DT,
            Platanias LC, Zhang ZY and Liu Y.
  TITLE     PRL2 phosphatase enhances oncogenic FLT3 signaling via
            dephosphorylation of the E3 ubiquitin ligase CBL at tyrosine 371
  JOURNAL   Blood 141 (3), 244-259 (2023)
   PUBMED   36206490
REFERENCE   5  (residues 1 to 91)
  AUTHORS   Brahma MK, Xiao P, Popa M, Negueruela J, Vandenbempt V, Demine S,
            Cardozo AK and Gurzov EN.
  TITLE     Nova1 or Bim Deficiency in Pancreatic beta-Cells Does Not Alter
            Multiple Low-Dose Streptozotocin-Induced Diabetes and Diet-Induced
            Obesity in Mice
  JOURNAL   Nutrients 14 (18), 3866 (2022)
   PUBMED   36145242
  REMARK    GeneRIF: Nova1 or Bim Deficiency in Pancreatic beta-Cells Does Not
            Alter Multiple Low-Dose Streptozotocin-Induced Diabetes and
            Diet-Induced Obesity in Mice.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 91)
  AUTHORS   Bouillet P, Zhang LC, Huang DC, Webb GC, Bottema CD, Shore P, Eyre
            HJ, Sutherland GR and Adams JM.
  TITLE     Gene structure alternative splicing, and chromosomal localization
            of pro-apoptotic Bcl-2 relative Bim
  JOURNAL   Mamm Genome 12 (2), 163-168 (2001)
   PUBMED   11210187
REFERENCE   7  (residues 1 to 91)
  AUTHORS   Bouillet P, Metcalf D, Huang DC, Tarlinton DM, Kay TW, Kontgen F,
            Adams JM and Strasser A.
  TITLE     Proapoptotic Bcl-2 relative Bim required for certain apoptotic
            responses, leukocyte homeostasis, and to preclude autoimmunity
  JOURNAL   Science 286 (5445), 1735-1738 (1999)
   PUBMED   10576740
REFERENCE   8  (residues 1 to 91)
  AUTHORS   Puthalakath H, Huang DC, O'Reilly LA, King SM and Strasser A.
  TITLE     The proapoptotic activity of the Bcl-2 family member Bim is
            regulated by interaction with the dynein motor complex
  JOURNAL   Mol Cell 3 (3), 287-296 (1999)
   PUBMED   10198631
REFERENCE   9  (residues 1 to 91)
  AUTHORS   Reed JC.
  TITLE     Bcl-2 family proteins
  JOURNAL   Oncogene 17 (25), 3225-3236 (1998)
   PUBMED   9916985
  REMARK    Review article
REFERENCE   10 (residues 1 to 91)
  AUTHORS   O'Connor L, Strasser A, O'Reilly LA, Hausmann G, Adams JM, Cory S
            and Huang DC.
  TITLE     Bim: a novel member of the Bcl-2 family that promotes apoptosis
  JOURNAL   EMBO J 17 (2), 384-395 (1998)
   PUBMED   9430630
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL805950.11.
            
            On May 9, 2022 this sequence version replaced NP_001271339.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422598.789237.1, BC058175.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849378, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..91
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 62.23 cM"
     Protein         1..91
                     /product="bcl-2-like protein 11 isoform 4"
                     /note="bcl-2-like protein 11; bcl2-interacting mediator of
                     cell death; Bcl2 interacting mediator of cell death;
                     BCL2-like 11 (apoptosis facilitator)"
                     /calculated_mol_wt=9862
     Region          4..40
                     /region_name="Bim_N"
                     /note="Bim protein N-terminus; pfam06773"
                     /db_xref="CDD:429111"
     CDS             1..91
                     /gene="Bcl2l11"
                     /gene_synonym="1500006F24Rik; bcl2-L-11; Bim; Bod"
                     /coded_by="NM_001284410.3:221..496"
                     /note="isoform 4 is encoded by transcript variant 4"
                     /db_xref="GeneID:12125"
                     /db_xref="MGI:MGI:1197519"
ORIGIN      
        1 makqpsdvss ecdreggqlq paerppqlrp gaptslqtep qdrspapmsc dkstqtpspp
       61 cqafnhylsa mdqlenlnqv aqnihgdawy n
//
LOCUS       NP_001342569             415 aa            linear   ROD 09-OCT-2023
DEFINITION  5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 2
            [Mus musculus].
ACCESSION   NP_001342569 XP_006520016
VERSION     NP_001342569.1
DBSOURCE    REFSEQ: accession NM_001355640.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 415)
  AUTHORS   Yang Y, Yuan K, Liu Y, Wang Q, Lin Y, Yang S, Huang K, Kan T, Zhang
            Y, Xu M, Yu Z, Fan Q, Wang Y, Li H and Tang T.
  TITLE     Constitutively activated AMPKalpha1 protects against skeletal aging
            in mice by promoting bone-derived IGF-1 secretion
  JOURNAL   Cell Prolif 56 (10), e13476 (2023)
   PUBMED   37042047
  REMARK    GeneRIF: Constitutively activated AMPKalpha1 protects against
            skeletal aging in mice by promoting bone-derived IGF-1 secretion.
REFERENCE   2  (residues 1 to 415)
  AUTHORS   Zahedi E, Sadr SS, Sanaeierad A and Roghani M.
  TITLE     Valproate-induced murine autism spectrum disorder is associated
            with dysfunction of amygdala parvalbumin interneurons and
            downregulation of AMPK/SIRT1/PGC1alpha signaling
  JOURNAL   Metab Brain Dis 38 (6), 2093-2103 (2023)
   PUBMED   37184727
  REMARK    GeneRIF: Valproate-induced murine autism spectrum disorder is
            associated with dysfunction of amygdala parvalbumin interneurons
            and downregulation of AMPK/SIRT1/PGC1alpha signaling.
REFERENCE   3  (residues 1 to 415)
  AUTHORS   Knaus LS, Basilico B, Malzl D, Gerykova Bujalkova M, Smogavec M,
            Schwarz LA, Gorkiewicz S, Amberg N, Pauler FM, Knittl-Frank C,
            Tassinari M, Maulide N, Rulicke T, Menche J, Hippenmeyer S and
            Novarino G.
  TITLE     Large neutral amino acid levels tune perinatal neuronal
            excitability and survival
  JOURNAL   Cell 186 (9), 1950-1967 (2023)
   PUBMED   36996814
REFERENCE   4  (residues 1 to 415)
  AUTHORS   Bustamante-Barrientos FA, Mendez-Ruette M, Molina L, Koning T,
            Ehrenfeld P, Gonzalez CB, Wyneken U, Henzi R and Batiz LF.
  TITLE     Alpha-SNAP (M105I) mutation promotes neuronal differentiation of
            neural stem/progenitor cells through overactivation of AMPK
  JOURNAL   Front Cell Dev Biol 11, 1061777 (2023)
   PUBMED   37113766
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 415)
  AUTHORS   Aguiar CF, Correa-da-Silva F, Gonzatti MB, Angelim MK, Pretti MA,
            Davanzo GG, Castelucci BG, Monteiro LB, Castro G, Virgilio-da-Silva
            JV, Ribeiro G, Jaccomo V, Pereira Andrade MC, Costa WL, Gambarini
            V, Terra FF, Alves-Filho JC, Saraiva Camara NO, Boroni M, Keller AC
            and Moraes-Vieira PM.
  TITLE     Tissue-specific metabolic profile drives iNKT cell function during
            obesity and liver injury
  JOURNAL   Cell Rep 42 (1), 112035 (2023)
   PUBMED   36848232
REFERENCE   6  (residues 1 to 415)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (residues 1 to 415)
  AUTHORS   Sato T, Sato-Harada R, Takano M, Kato S, Saburi S and Harada A.
  TITLE     Localization of cAMP-dependent protein kinase in the actin and
            microtubule cytoskeletons in mouse hippocampal neurons
  JOURNAL   Neurosci Lett 325 (2), 83-86 (2002)
   PUBMED   12044627
REFERENCE   8  (residues 1 to 415)
  AUTHORS   Fryer LG, Foufelle F, Barnes K, Baldwin SA, Woods A and Carling D.
  TITLE     Characterization of the role of the AMP-activated protein kinase in
            the stimulation of glucose transport in skeletal muscle cells
  JOURNAL   Biochem J 363 (Pt 1), 167-174 (2002)
   PUBMED   11903059
REFERENCE   9  (residues 1 to 415)
  AUTHORS   Piao Y, Ko NT, Lim MK and Ko MS.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (residues 1 to 415)
  AUTHORS   Turnley AM, Stapleton D, Mann RJ, Witters LA, Kemp BE and Bartlett
            PF.
  TITLE     Cellular distribution and developmental expression of AMP-activated
            protein kinase isoforms in mouse central nervous system
  JOURNAL   J Neurochem 72 (4), 1707-1716 (1999)
   PUBMED   10098881
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC135079.9.
            
            On Sep 22, 2017 this sequence version replaced XP_006520016.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.149686.1,
                                           ERR3363658.2031903.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..415
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 1.99 cM"
     Protein         1..415
                     /product="5'-AMP-activated protein kinase catalytic
                     subunit alpha-1 isoform 2"
                     /EC_number="2.7.11.1"
                     /EC_number="2.7.11.26"
                     /EC_number="2.7.11.27"
                     /EC_number="2.7.11.31"
                     /note="5'-AMP-activated protein kinase catalytic subunit
                     alpha-1; AMP-activated protein kinase, alpha 1 catalytic
                     subunit; AMPK subunit alpha-1; ACACA kinase; HMGCR kinase;
                     acetyl-CoA carboxylase kinase; hydroxymethylglutaryl-CoA
                     reductase kinase; tau-protein kinase PRKAA1"
                     /calculated_mol_wt=47089
     Region          <1..135
                     /region_name="PKc_like"
                     /note="Protein Kinases, catalytic domain; cl21453"
                     /db_xref="CDD:451246"
     Region          152..216
                     /region_name="UBA_AID_AAPK1"
                     /note="UBA-like autoinhibitory domain (AID) found in
                     vertebrate 5'-AMP-activated protein kinase catalytic
                     subunit alpha-1 (AMPKalpha-1); cd14403"
                     /db_xref="CDD:270586"
     Region          260..413
                     /region_name="AMPKA1_C"
                     /note="C-terminal regulatory domain of 5'-AMP-activated
                     protein kinase (AMPK) alpha 1 catalytic subunit; cd12199"
                     /db_xref="CDD:213384"
     Site            order(260..266,268,273,295..297,317..321,326,329..332,334,
                     399,402..404,406..407,411)
                     /site_type="other"
                     /note="beta subunit interface [polypeptide binding]"
                     /db_xref="CDD:213384"
     Site            order(260,305,307,397..398,400..401,404)
                     /site_type="other"
                     /note="gamma subunit interface [polypeptide binding]"
                     /db_xref="CDD:213384"
     CDS             1..415
                     /gene="Prkaa1"
                     /gene_synonym="AMPKalpha1; C130083N04Rik"
                     /coded_by="NM_001355640.1:347..1594"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="GeneID:105787"
                     /db_xref="MGI:MGI:2145955"
ORIGIN      
        1 mvvhrdlkpe nvlldahmna kiadfglsnm msdgeflrts cgspnyaape visgrlyagp
       61 evdiwssgvi lyallcgtlp fdddhvptlf kkicdgifyt pqylnpsvis llkhmlqvdp
      121 mkraaikdir ehewfkqdlp kylfpedpsy sstmiddeal kevcekfecs eeevlsclyn
      181 rnhqdplava yhliidnrri mneakdfyla tsppdsfldd hhltrphper vpflvaetpr
      241 arhtldelnp qkskhqgvrk akwhlgirsq srpndimaev craikqldye wkvvnpyylr
      301 vrrknpvtst fskmslqlyq vdsrtylldf rsiddeitea ksgtatpqrs gsisnyrscq
      361 rsdsdaeaqg kpsdvsltss vtsldsspvd vaprpgshti effemcanli kilaq
//
LOCUS       NP_058545                419 aa            linear   ROD 09-OCT-2023
DEFINITION  interferon regulatory factor 3 [Mus musculus].
ACCESSION   NP_058545
VERSION     NP_058545.1
DBSOURCE    REFSEQ: accession NM_016849.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 419)
  AUTHORS   Bourdon M, Manet C, Conquet L, Ramauge Parra C, Kornobis E,
            Bonnefoy E and Montagutelli X.
  TITLE     Susceptibility to Zika virus in a Collaborative Cross mouse strain
            is induced by Irf3 deficiency in vitro but requires other variants
            in vivo
  JOURNAL   PLoS Pathog 19 (9), e1011446 (2023)
   PUBMED   37733807
  REMARK    GeneRIF: Susceptibility to Zika virus in a Collaborative Cross
            mouse strain is induced by Irf3 deficiency in vitro but requires
            other variants in vivo.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 419)
  AUTHORS   Choi YA, Dhakal H, Lee S, Kim N, Lee B, Kwon TK, Khang D and Kim
            SH.
  TITLE     IRF3 Activation in Mast Cells Promotes FcepsilonRI-Mediated
            Allergic Inflammation
  JOURNAL   Cells 12 (11), 1493 (2023)
   PUBMED   37296614
  REMARK    GeneRIF: IRF3 Activation in Mast Cells Promotes
            FcepsilonRI-Mediated Allergic Inflammation.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 419)
  AUTHORS   Wu H, Yan X, Zhao L, Li X, Li X, Zhang Y, Gu C, Yang F, Yan J, Lou
            Y, Li Y, Yang L, Qin X and Wang Y.
  TITLE     p120-catenin promotes innate antiviral immunity through stabilizing
            TBK1-IRF3 complex
  JOURNAL   Mol Immunol 157, 8-17 (2023)
   PUBMED   36958140
  REMARK    GeneRIF: p120-catenin promotes innate antiviral immunity through
            stabilizing TBK1-IRF3 complex.
REFERENCE   4  (residues 1 to 419)
  AUTHORS   Wang S, Chu F, Xia R, Guan J, Zhou L, Fang X, Dai T, Xie F, Zhang L
            and Zhou F.
  TITLE     LPA maintains innate antiviral immunity in a pro-active state via
            STK38L-mediated IRF3 Ser303 phosphorylation
  JOURNAL   Cell Rep 41 (8), 111661 (2022)
   PUBMED   36417850
  REMARK    GeneRIF: LPA maintains innate antiviral immunity in a pro-active
            state via STK38L-mediated IRF3 Ser303 phosphorylation.
REFERENCE   5  (residues 1 to 419)
  AUTHORS   Ko R, Seo J, Park H, Lee N and Lee SY.
  TITLE     Pim1 promotes IFN-beta production by interacting with IRF3
  JOURNAL   Exp Mol Med 54 (11), 2092-2103 (2022)
   PUBMED   36446848
  REMARK    GeneRIF: Pim1 promotes IFN-beta production by interacting with
            IRF3.
REFERENCE   6  (residues 1 to 419)
  AUTHORS   Stockinger S, Materna T, Stoiber D, Bayr L, Steinborn R, Kolbe T,
            Unger H, Chakraborty T, Levy DE, Muller M and Decker T.
  TITLE     Production of type I IFN sensitizes macrophages to cell death
            induced by Listeria monocytogenes
  JOURNAL   J Immunol 169 (11), 6522-6529 (2002)
   PUBMED   12444163
  REMARK    GeneRIF: activation of transcription factor IFN regulatory factor
            3, the synthesis of large amounts of IFN-beta mRNA, and
            IFN-alpha/beta signal transduction in macrophages infected with
            Listeria monocytogenes
REFERENCE   7  (residues 1 to 419)
  AUTHORS   Suhara W, Yoneyama M, Kitabayashi I and Fujita T.
  TITLE     Direct involvement of CREB-binding protein/p300 in
            sequence-specific DNA binding of virus-activated interferon
            regulatory factor-3 holocomplex
  JOURNAL   J Biol Chem 277 (25), 22304-22313 (2002)
   PUBMED   11940575
  REMARK    GeneRIF: Direct involvement of CREB-binding protein/p300 in
            sequence-specific DNA binding of virus-activated interferon
            regulatory factor-3 holocomplex.
REFERENCE   8  (residues 1 to 419)
  AUTHORS   Malakhova O, Malakhov M, Hetherington C and Zhang DE.
  TITLE     Lipopolysaccharide activates the expression of ISG15-specific
            protease UBP43 via interferon regulatory factor 3
  JOURNAL   J Biol Chem 277 (17), 14703-14711 (2002)
   PUBMED   11854279
  REMARK    GeneRIF: role in regulating expression of ISG15-specific protease
            UBP43 in conjunction with lipopolysaccharide
REFERENCE   9  (residues 1 to 419)
  AUTHORS   Sato M, Suemori H, Hata N, Asagiri M, Ogasawara K, Nakao K, Nakaya
            T, Katsuki M, Noguchi S, Tanaka N and Taniguchi T.
  TITLE     Distinct and essential roles of transcription factors IRF-3 and
            IRF-7 in response to viruses for IFN-alpha/beta gene induction
  JOURNAL   Immunity 13 (4), 539-548 (2000)
   PUBMED   11070172
REFERENCE   10 (residues 1 to 419)
  AUTHORS   Bellingham J, Gregory-Evans K and Gregory-Evans CY.
  TITLE     Mapping of human interferon regulatory factor 3 (IRF3) to
            chromosome 19q13.3-13.4 by an intragenic polymorphic marker
  JOURNAL   Ann Hum Genet 62 (Pt 3), 231-234 (1998)
   PUBMED   9803267
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY089035.1, AK013944.1, AK151750.1 and BC050882.1.
            
            Transcript Variant: This variant (1) represents the protein-coding
            transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050882.1, AK013944.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..419
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 29.07 cM"
     Protein         1..419
                     /product="interferon regulatory factor 3"
                     /calculated_mol_wt=46721
     Site            3
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q14653; propagated from
                     UniProtKB/Swiss-Prot (P70671.1)"
     Region          7..110
                     /region_name="IRF"
                     /note="Interferon regulatory factor transcription factor;
                     pfam00605"
                     /db_xref="CDD:425772"
     Site            14
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q14653; propagated from
                     UniProtKB/Swiss-Prot (P70671.1)"
     Site            order(40,79,81..82,85)
                     /site_type="other"
                     /note="DNA sequence recognition sites [nucleotide
                     binding]"
                     /db_xref="CDD:238051"
     Site            75
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q14653; propagated from
                     UniProtKB/Swiss-Prot (P70671.1)"
     Site            order(84..85,87,90)
                     /site_type="metal-binding"
                     /db_xref="CDD:238051"
     Site            97
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q14653; propagated from
                     UniProtKB/Swiss-Prot (P70671.1)"
     Site            121..122
                     /site_type="cleavage"
                     /note="Cleavage, by CASP3.
                     /evidence=ECO:0000250|UniProtKB:Q14653; propagated from
                     UniProtKB/Swiss-Prot (P70671.1)"
     Site            123
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P70671.1)"
     Site            125..126
                     /site_type="cleavage"
                     /note="Cleavage, by CASP3.
                     /evidence=ECO:0000250|UniProtKB:Q14653; propagated from
                     UniProtKB/Swiss-Prot (P70671.1)"
     Site            135
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P70671.1)"
     Region          140..419
                     /region_name="Mediates interaction with ZDHHC11.
                     /evidence=ECO:0000250|UniProtKB:Q14653"
                     /note="propagated from UniProtKB/Swiss-Prot (P70671.1)"
     Region          194..353
                     /region_name="Interaction with HERC5.
                     /evidence=ECO:0000250|UniProtKB:Q14653"
                     /note="propagated from UniProtKB/Swiss-Prot (P70671.1)"
     Region          196..373
                     /region_name="IRF-3"
                     /note="Interferon-regulatory factor 3; pfam10401"
                     /db_xref="CDD:431258"
     Site            230
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q14653; propagated from
                     UniProtKB/Swiss-Prot (P70671.1)"
     Site            237
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q14653; propagated from
                     UniProtKB/Swiss-Prot (P70671.1)"
     Site            246
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q14653; propagated from
                     UniProtKB/Swiss-Prot (P70671.1)"
     Site            378
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q14653; propagated from
                     UniProtKB/Swiss-Prot (P70671.1)"
     Site            379
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by TBK1.
                     /evidence=ECO:0000250|UniProtKB:Q14653; propagated from
                     UniProtKB/Swiss-Prot (P70671.1)"
     Site            388
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by IKKE.
                     /evidence=ECO:0000250|UniProtKB:Q14653; propagated from
                     UniProtKB/Swiss-Prot (P70671.1)"
     Site            390
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q14653; propagated from
                     UniProtKB/Swiss-Prot (P70671.1)"
     Site            396
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q14653; propagated from
                     UniProtKB/Swiss-Prot (P70671.1)"
     CDS             1..419
                     /gene="Irf3"
                     /gene_synonym="C920001K05Rik; IRF-3"
                     /coded_by="NM_016849.4:270..1529"
                     /db_xref="CCDS:CCDS21224.1"
                     /db_xref="GeneID:54131"
                     /db_xref="MGI:MGI:1859179"
ORIGIN      
        1 metpkprilp wlvsqldlgq legvawldes rtrfripwkh glrqdaqmad fgifqawaea
       61 sgaytpgkdk pdvstwkrnf rsalnrkevl rlaadnskdp ydphkvyefv tpgardfvhl
      121 gaspdtngks slphsqenlp klfdglilgp lkdegssdla ivsdpsqqlp spnvnnflnp
      181 apqenplkql laeeqwefev tafyrgrqvf qqtlfcpggl rlvgstadmt lpwqpvtlpd
      241 pegfltdklv keyvgqvlkg lgnglalwqa gqclwaqrlg hshafwalge ellpdsgrgp
      301 dgevhkdkdg avfdlrpfva dliafmegsg hsprytlwfc mgemwpqdqp wvkrlvmvkv
      361 vptclkelle mareggassl ktvdlhisns qpisltsdqy kaylqdlved mdfqatgni
//
LOCUS       NP_062804                371 aa            linear   ROD 09-OCT-2023
DEFINITION  protein arginine N-methyltransferase 1 isoform 1 [Mus musculus].
ACCESSION   NP_062804
VERSION     NP_062804.1
DBSOURCE    REFSEQ: accession NM_019830.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 371)
  AUTHORS   Ye H, Cao L, Jackson-Weaver O, Zheng L and Gou Y.
  TITLE     PRMT1-mediated arginine methylation promotes postnatal calvaria
            bone formation through BMP-Smad signaling
  JOURNAL   Bone 176, 116887 (2023)
   PUBMED   37634683
  REMARK    GeneRIF: PRMT1-mediated arginine methylation promotes postnatal
            calvaria bone formation through BMP-Smad signaling.
REFERENCE   2  (residues 1 to 371)
  AUTHORS   Zhu Y, Wang L, Liu R, Ding X, Yin S, Chen Y, Zhu C, Wang Z and Li
            W.
  TITLE     Inhibition of PRMT1 alleviates sepsis-induced acute kidney injury
            in mice by blocking the TGF-beta1 and IL-6 trans-signaling pathways
  JOURNAL   FEBS Open Bio 13 (10), 1859-1873 (2023)
   PUBMED   37525933
  REMARK    GeneRIF: Inhibition of PRMT1 alleviates sepsis-induced acute kidney
            injury in mice by blocking the TGF-beta1 and IL-6 trans-signaling
            pathways.
REFERENCE   3  (residues 1 to 371)
  AUTHORS   Litzler LC, Zahn A, Dionne KL, Sprumont A, Ferreira SR, Slattery
            MRF, Methot SP, Patenaude AM, Hebert S, Kabir N, Subramani PG, Jung
            S, Richard S, Kleinman CL and Di Noia JM.
  TITLE     Protein arginine methyltransferase 1 regulates B cell fate after
            positive selection in the germinal center in mice
  JOURNAL   J Exp Med 220 (9) (2023)
   PUBMED   37310381
  REMARK    GeneRIF: Protein arginine methyltransferase 1 regulates B cell fate
            after positive selection in the germinal center in mice.
REFERENCE   4  (residues 1 to 371)
  AUTHORS   Li Q, Jiao J, Heng Y, Lu Q, Zheng Y, Li H, Cai J, Mei M and Bao S.
  TITLE     Prmt5 promotes ciliated cell specification of airway epithelial
            progenitors via transcriptional inhibition of Tp63
  JOURNAL   J Biol Chem 299 (8), 104964 (2023)
   PUBMED   37364687
REFERENCE   5  (residues 1 to 371)
  AUTHORS   Liu J, Bu X, Chu C, Dai X, Asara JM, Sicinski P, Freeman GJ and Wei
            W.
  TITLE     PRMT1 mediated methylation of cGAS suppresses anti-tumor immunity
  JOURNAL   Nat Commun 14 (1), 2806 (2023)
   PUBMED   37193698
  REMARK    GeneRIF: PRMT1 mediated methylation of cGAS suppresses anti-tumor
            immunity.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 371)
  AUTHORS   Cimato TR, Tang J, Xu Y, Guarnaccia C, Herschman HR, Pongor S and
            Aletta JM.
  TITLE     Nerve growth factor-mediated increases in protein methylation occur
            predominantly at type I arginine methylation sites and involve
            protein arginine methyltransferase 1
  JOURNAL   J Neurosci Res 67 (4), 435-442 (2002)
   PUBMED   11835310
  REMARK    GeneRIF: Type I protein arginine methyltransferase (PRMT) activity
            produces asymmetric dimethylation of the terminal guanidinonitrogen
            of arginines in substrate proteins, particularly glycine and
            arginine-rich (GAR) segments of proteins
REFERENCE   7  (residues 1 to 371)
  AUTHORS   Pawlak MR, Scherer CA, Chen J, Roshon MJ and Ruley HE.
  TITLE     Arginine N-methyltransferase 1 is required for early
            postimplantation mouse development, but cells deficient in the
            enzyme are viable
  JOURNAL   Mol Cell Biol 20 (13), 4859-4869 (2000)
   PUBMED   10848611
REFERENCE   8  (residues 1 to 371)
  AUTHORS   Brady KP, Rowe LB, Her H, Stevens TJ, Eppig J, Sussman DJ, Sikela J
            and Beier DR.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
REFERENCE   9  (residues 1 to 371)
  AUTHORS   Scherer CA, Chen J, Nachabeh A, Hopkins N and Ruley HE.
  TITLE     Transcriptional specificity of the pluripotent embryonic stem cell
  JOURNAL   Cell Growth Differ 7 (10), 1393-1401 (1996)
   PUBMED   8891343
REFERENCE   10 (residues 1 to 371)
  AUTHORS   Lin WJ, Gary JD, Yang MC, Clarke S and Herschman HR.
  TITLE     The mammalian immediate-early TIS21 protein and the
            leukemia-associated BTG1 protein interact with a protein-arginine
            N-methyltransferase
  JOURNAL   J Biol Chem 271 (25), 15034-15044 (1996)
   PUBMED   8663146
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU524421.1, AF232716.1, BY760714.1 and AI846916.1.
            
            Transcript Variant: This variant (1) encodes the longest protein
            (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF232716.1, SRR7652917.572245.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..371
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 29.07 cM"
     Protein         1..371
                     /product="protein arginine N-methyltransferase 1 isoform
                     1"
                     /EC_number="2.1.1.319"
                     /note="arginine N-methyltransferase 1; histone-arginine
                     N-methyltransferase PRMT1; heterogeneous nuclear
                     ribonucleoproteins methyltransferase-like 2"
                     /calculated_mol_wt=42305
     Region          92..192
                     /region_name="AdoMet_MTases"
                     /note="S-adenosylmethionine-dependent methyltransferases
                     (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes
                     that use S-adenosyl-L-methionine (SAM or AdoMet) as a
                     substrate for methyltransfer, creating the product
                     S-adenosyl-L-homocysteine (AdoHcy); cd02440"
                     /db_xref="CDD:100107"
     Site            order(95..101,118,122,144..146,163)
                     /site_type="other"
                     /note="S-adenosylmethionine binding site [chemical
                     binding]"
                     /db_xref="CDD:100107"
     Site            228
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000269|PubMed:28883095; propagated from
                     UniProtKB/Swiss-Prot (Q9JIF0.1)"
     Site            233
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000269|PubMed:28883095; propagated from
                     UniProtKB/Swiss-Prot (Q9JIF0.1)"
     Site            304
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q99873; propagated from
                     UniProtKB/Swiss-Prot (Q9JIF0.1)"
     Site            307
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q99873; propagated from
                     UniProtKB/Swiss-Prot (Q9JIF0.1)"
     CDS             1..371
                     /gene="Prmt1"
                     /gene_synonym="6720434D09Rik; Hrmt1l2; Mrmt1"
                     /coded_by="NM_019830.3:103..1218"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS21222.1"
                     /db_xref="GeneID:15469"
                     /db_xref="MGI:MGI:107846"
ORIGIN      
        1 maaaeaanci menfvatlan gmslqpplee vscgqaesse kpnaedmtsk dyyfdsyahf
       61 giheemlkde vrtltyrnsm fhnrhlfkdk vvldvgsgtg ilcmfaakag arkvigiecs
      121 sisdyavkiv kankldhvvt iikgkveeve lpvekvdiii sewmgyclfy esmlntvlha
      181 rdkwlapdgl ifpdratlyv taiedrqykd ykihwwenvy gfdmscikdv aikeplvdvv
      241 dpkqlvtnac likevdiytv kvedltftsp fclqvkrndy vhalvayfni eftrchkrtg
      301 fstspespyt hwkqtvfyme dyltvktgee ifgtigmrpn aknnrdldft idldfkgqlc
      361 elscstdyrm r
//
LOCUS       NP_001129545             923 aa            linear   ROD 09-OCT-2023
DEFINITION  nuclear factor of activated T-cells, cytoplasmic 2 isoform d [Mus
            musculus].
ACCESSION   NP_001129545
VERSION     NP_001129545.1
DBSOURCE    REFSEQ: accession NM_001136073.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 923)
  AUTHORS   Fu Y, Wang J, Liu C, Liao K, Gao X, Tang R, Fan B, Hong Y, Xiao N,
            Xiao C and Liu WH.
  TITLE     Glycogen synthase kinase 3 controls T-cell exhaustion by regulating
            NFAT activation
  JOURNAL   Cell Mol Immunol 20 (10), 1127-1139 (2023)
   PUBMED   37553428
  REMARK    GeneRIF: Glycogen synthase kinase 3 controls T-cell exhaustion by
            regulating NFAT activation.
REFERENCE   2  (residues 1 to 923)
  AUTHORS   Wan X, Zhao S, Dai Y, Zhang J, Shen Y, Gong L and Le Q.
  TITLE     WNT16b promotes the proliferation and self-renewal of human limbal
            epithelial stem/progenitor cells via activating the
            calcium/calcineurin A/NFATC2 pathway
  JOURNAL   Cell Prolif 56 (10), e13460 (2023)
   PUBMED   36974338
  REMARK    GeneRIF: WNT16b promotes the proliferation and self-renewal of
            human limbal epithelial stem/progenitor cells via activating the
            calcium/calcineurin A/NFATC2 pathway.
REFERENCE   3  (residues 1 to 923)
  AUTHORS   Jiang F, Guo Y, Hu L, Zhang M, Meng J, Si Y and Shi H.
  TITLE     Role of nuclear factor of activated T Cells-1 in Sepsis-induced
            behavioral deficits in mice
  JOURNAL   Brain Res 1806, 148299 (2023)
   PUBMED   36842570
REFERENCE   4  (residues 1 to 923)
  AUTHORS   Nagai J, Lin J and Boyce JA.
  TITLE     Macrophage P2Y6 Receptor Signaling Selectively Activates NFATC2 and
            Suppresses Allergic Lung Inflammation
  JOURNAL   J Immunol 209 (12), 2293-2303 (2022)
   PUBMED   36307120
  REMARK    GeneRIF: Macrophage P2Y6 Receptor Signaling Selectively Activates
            NFATC2 and Suppresses Allergic Lung Inflammation.
REFERENCE   5  (residues 1 to 923)
  AUTHORS   Zhu L, Zhou X, Gu M, Kim J, Li Y, Ko CJ, Xie X, Gao T, Cheng X and
            Sun SC.
  TITLE     Dapl1 controls NFATc2 activation to regulate CD8+ T cell exhaustion
            and responses in chronic infection and cancer
  JOURNAL   Nat Cell Biol 24 (7), 1165-1176 (2022)
   PUBMED   35773432
REFERENCE   6  (residues 1 to 923)
  AUTHORS   Vihma H, Pruunsild P and Timmusk T.
  TITLE     Alternative splicing and expression of human and mouse NFAT genes
  JOURNAL   Genomics 92 (5), 279-291 (2008)
   PUBMED   18675896
REFERENCE   7  (residues 1 to 923)
  AUTHORS   Ho SN, Thomas DJ, Timmerman LA, Li X, Francke U and Crabtree GR.
  TITLE     NFATc3, a lymphoid-specific NFATc family member that is
            calcium-regulated and exhibits distinct DNA binding specificity
  JOURNAL   J Biol Chem 270 (34), 19898-19907 (1995)
   PUBMED   7650004
REFERENCE   8  (residues 1 to 923)
  AUTHORS   Jain J, Burgeon E, Badalian TM, Hogan PG and Rao A.
  TITLE     A similar DNA-binding motif in NFAT family proteins and the Rel
            homology region
  JOURNAL   J Biol Chem 270 (8), 4138-4145 (1995)
   PUBMED   7876165
REFERENCE   9  (residues 1 to 923)
  AUTHORS   Li X, Ho SN, Luna J, Giacalone J, Thomas DJ, Timmerman LA, Crabtree
            GR and Francke U.
  TITLE     Cloning and chromosomal localization of the human and murine genes
            for the T-cell transcription factors NFATc and NFATp
  JOURNAL   Cytogenet Cell Genet 68 (3-4), 185-191 (1995)
   PUBMED   7842733
REFERENCE   10 (residues 1 to 923)
  AUTHORS   Ho AM, Jain J, Rao A and Hogan PG.
  TITLE     Expression of the transcription factor NFATp in a neuronal cell
            line and in the murine nervous system
  JOURNAL   J Biol Chem 269 (45), 28181-28186 (1994)
   PUBMED   7961754
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK135414.1, EU887582.1 and BP757417.1.
            
            Transcript Variant: This variant (4, also known as IB-IIL-Xa)
            contains an additional exon that results in an alternate 3' coding
            region and 3' UTR, compared to variant 1. The encoded isoform (d)
            has a distinct C-terminus and is shorter than isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU887582.1, SRR10223971.3526.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..923
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 88.91 cM"
     Protein         1..923
                     /product="nuclear factor of activated T-cells, cytoplasmic
                     2 isoform d"
                     /note="nuclear factor of activated T-cells, cytoplasmic 2;
                     NFAT pre-existing subunit; T-cell transcription factor
                     NFAT1"
                     /calculated_mol_wt=99511
     Region          400..574
                     /region_name="RHD-n_NFAT"
                     /note="N-terminal sub-domain of the Rel homology domain
                     (RHD) of nuclear factor of activated T-cells (NFAT)
                     proteins; cd07881"
                     /db_xref="CDD:143641"
     Site            order(423,426,428..429,431..433,481,522,524..525,539..540,
                     542,573)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143641"
     Region          579..679
                     /region_name="IPT_NFAT"
                     /note="IPT domain of the NFAT family of transcription
                     factors. NFAT transcription complexes are a target of
                     calcineurin, a calcium dependent phosphatase, and activate
                     genes mainly involved in cell-cell-interaction; cd01178"
                     /db_xref="CDD:238583"
     Site            order(603,667)
                     /site_type="DNA binding"
                     /note="DNA binding sites [nucleotide binding]"
                     /db_xref="CDD:238583"
     CDS             1..923
                     /gene="Nfatc2"
                     /gene_synonym="NF-ATc2; NF-ATp; NFAT1; NFAT1-D; Nfatp"
                     /coded_by="NM_001136073.2:175..2946"
                     /note="isoform d is encoded by transcript variant 4"
                     /db_xref="CCDS:CCDS50803.1"
                     /db_xref="GeneID:18019"
                     /db_xref="MGI:MGI:102463"
ORIGIN      
        1 mdvpepqpdp dggdgpghep ggspqdeldf silfdydyln pieeepiahk aisspsglay
       61 pddvldyglk pcnplaslsg eppgrfgepd sigfqnflsp vkpagasgps prieitpshe
      121 lmqaggalrg rdaglspeqp alalagvaas prftlpvpgy egyreplcls passgssasf
      181 isdtfspyts pcvspnnagp ddlcpqfqni pahysprtsp imsprtslae dsclgrhspv
      241 prpasrsssp gakrrhscae alvaplpaas pqrsrspspq psphvalqdd sipagyppta
      301 gsavlmdaln tlatdspcgi pskiwktspd ptpvstapsk aglarhiypt veflgpceqe
      361 errnsapesi llvpptwpkq lvpaipicsi pvtaslpple wplsnqsgsy elrievqpkp
      421 hhrahyeteg srgavkaptg ghpvvqlhgy menkplglqi figtaderil kphafyqvhr
      481 itgktvttts yekivgntkv leiplepknn mratidcagi lklrnadiel rkgetdigrk
      541 ntrvrlvfrv hvpepsgriv slqaasnpie csqrsahelp mverqdmdsc lvyggqqmil
      601 tgqnftaesk vvfmekttdg qqiwemeatv dkdksqpnml fveipeyrnk hirvpvkvnf
      661 yvingkrkrs qpqhftyhpv paiktepsde yepslicspa hgglgsqpyy pqhpmlaesp
      721 sclvatmapc qqfrsglssp daryqqqspa aalyqrsksl spgllgyqqp sllaaplgla
      781 dahrsvlvha gsqgqgqgst lphtssasqq aspvihyspt nqqlrggghq efqhimycen
      841 fgpssarpgp ppinqgqrls pgayptviqq qtapsqraak ngpsdqkeal ptgvtvkqeq
      901 nldqtyldde lidthlswiq nil
//
LOCUS       NP_001334238             290 aa            linear   ROD 09-OCT-2023
DEFINITION  tumor necrosis factor ligand superfamily member 13B isoform 2 [Mus
            musculus].
ACCESSION   NP_001334238 XP_006508837
VERSION     NP_001334238.1
DBSOURCE    REFSEQ: accession NM_001347309.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 290)
  AUTHORS   Doll JR, Moreno-Fernandez ME, Stankiewicz TE, Wayland JL, Wilburn
            A, Weinhaus B, Chougnet CA, Giordano D, Cappelletti M, Presicce P,
            Kallapur SG, Salomonis N, Tilburgs T and Divanovic S.
  TITLE     BAFF and APRIL counterregulate susceptibility to
            inflammation-induced preterm birth
  JOURNAL   Cell Rep 42 (4), 112352 (2023)
   PUBMED   37027297
  REMARK    GeneRIF: BAFF and APRIL counterregulate susceptibility to
            inflammation-induced preterm birth.
REFERENCE   2  (residues 1 to 290)
  AUTHORS   Giordano D, Kuley R, Draves KE, Elkon KB, Giltiay NV and Clark EA.
  TITLE     B cell-activating factor (BAFF) from dendritic cells, monocytes and
            neutrophils is required for B cell maturation and autoantibody
            production in SLE-like autoimmune disease
  JOURNAL   Front Immunol 14, 1050528 (2023)
   PUBMED   36923413
  REMARK    GeneRIF: B cell-activating factor (BAFF) from dendritic cells,
            monocytes and neutrophils is required for B cell maturation and
            autoantibody production in SLE-like autoimmune disease.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 290)
  AUTHORS   Kanemitsu-Okada K, Abe M, Nakamura Y, Miyake T, Watanabe T, Yoshida
            O, Koizumi Y, Hirooka M, Tokumoto Y, Matsuura B, Koizumi M and
            Hiasa Y.
  TITLE     Role of B Cell-Activating Factor in Fibrosis Progression in a
            Murine Model of Non-Alcoholic Steatohepatitis
  JOURNAL   Int J Mol Sci 24 (3), 2509 (2023)
   PUBMED   36768854
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 290)
  AUTHORS   Stohl W, Yu N and Wu Y.
  TITLE     B Cell and T Cell Dissimilarities in BAFF-Deficient versus
            BR3-Deficient C57BL/6 Mice
  JOURNAL   J Immunol 209 (11), 2133-2140 (2022)
   PUBMED   36426969
  REMARK    GeneRIF: B Cell and T Cell Dissimilarities in BAFF-Deficient versus
            BR3-Deficient C57BL/6 Mice.
REFERENCE   5  (residues 1 to 290)
  AUTHORS   Liu W, Stachura P, Xu HC, Varaljai R, Shinde P, Ganesh NU, Mack M,
            Van Lierop A, Huang A, Sundaram B, Lang KS, Picard D, Fischer U,
            Remke M, Homey B, Roesch A, Haussinger D, Lang PA, Borkhardt A and
            Pandyra AA.
  TITLE     BAFF Attenuates Immunosuppressive Monocytes in the Melanoma Tumor
            Microenvironment
  JOURNAL   Cancer Res 82 (2), 264-277 (2022)
   PUBMED   34810198
  REMARK    GeneRIF: BAFF Attenuates Immunosuppressive Monocytes in the
            Melanoma Tumor Microenvironment.
REFERENCE   6  (residues 1 to 290)
  AUTHORS   Yu G, Boone T, Delaney J, Hawkins N, Kelley M, Ramakrishnan M,
            McCabe S, Qiu WR, Kornuc M, Xia XZ, Guo J, Stolina M, Boyle WJ,
            Sarosi I, Hsu H, Senaldi G and Theill LE.
  TITLE     APRIL and TALL-I and receptors BCMA and TACI: system for regulating
            humoral immunity
  JOURNAL   Nat Immunol 1 (3), 252-256 (2000)
   PUBMED   10973284
REFERENCE   7  (residues 1 to 290)
  AUTHORS   Xia XZ, Treanor J, Senaldi G, Khare SD, Boone T, Kelley M, Theill
            LE, Colombero A, Solovyev I, Lee F, McCabe S, Elliott R, Miner K,
            Hawkins N, Guo J, Stolina M, Yu G, Wang J, Delaney J, Meng SY,
            Boyle WJ and Hsu H.
  TITLE     TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis
            factor family member involved in B cell regulation
  JOURNAL   J Exp Med 192 (1), 137-143 (2000)
   PUBMED   10880535
REFERENCE   8  (residues 1 to 290)
  AUTHORS   Gross JA, Johnston J, Mudri S, Enselman R, Dillon SR, Madden K, Xu
            W, Parrish-Novak J, Foster D, Lofton-Day C, Moore M, Littau A,
            Grossman A, Haugen H, Foley K, Blumberg H, Harrison K, Kindsvogel W
            and Clegg CH.
  TITLE     TACI and BCMA are receptors for a TNF homologue implicated in
            B-cell autoimmune disease
  JOURNAL   Nature 404 (6781), 995-999 (2000)
   PUBMED   10801128
REFERENCE   9  (residues 1 to 290)
  AUTHORS   Mackay F, Woodcock SA, Lawton P, Ambrose C, Baetscher M, Schneider
            P, Tschopp J and Browning JL.
  TITLE     Mice transgenic for BAFF develop lymphocytic disorders along with
            autoimmune manifestations
  JOURNAL   J Exp Med 190 (11), 1697-1710 (1999)
   PUBMED   10587360
REFERENCE   10 (residues 1 to 290)
  AUTHORS   Schneider P, MacKay F, Steiner V, Hofmann K, Bodmer JL, Holler N,
            Ambrose C, Lawton P, Bixler S, Acha-Orbea H, Valmori D, Romero P,
            Werner-Favre C, Zubler RH, Browning JL and Tschopp J.
  TITLE     BAFF, a novel ligand of the tumor necrosis factor family,
            stimulates B cell growth
  JOURNAL   J Exp Med 189 (11), 1747-1756 (1999)
   PUBMED   10359578
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK079180.1, BC106840.1 and AC138397.4.
            
            On Nov 18, 2016 this sequence version replaced XP_006508837.1.
            
            Transcript Variant: This variant (2) lacks an in-frame exon in the
            central coding region, compared to variant 1. The encoded isoform
            (2) is shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC106840.1, AY290823.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..290
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 4.55 cM"
     Protein         1..290
                     /product="tumor necrosis factor ligand superfamily member
                     13B isoform 2"
                     /note="b cell-activating factor; tumor necrosis factor
                     ligand 7a"
                     /calculated_mol_wt=32035
     Region          164..287
                     /region_name="TNF"
                     /note="Tumor Necrosis Factor; TNF superfamily members
                     include the cytokines: TNF (TNF-alpha), LT
                     (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL),
                     Fas ligand, and osteoprotegerin (OPG) ligand. These
                     proteins generally have an intracellular N-terminal...;
                     cd00184"
                     /db_xref="CDD:238108"
     Site            order(174,176,214,221,230)
                     /site_type="active"
                     /note="receptor binding sites [active]"
                     /db_xref="CDD:238108"
     Site            order(199,201,251,256,283,287)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:238108"
     CDS             1..290
                     /gene="Tnfsf13b"
                     /gene_synonym="BAFF; BLyS; D8Ertd387e; TALL-1; TALL1;
                     THANK; TNFSF20; Tnlg7a; zTNF4"
                     /coded_by="NM_001347309.1:377..1249"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS85498.1"
                     /db_xref="GeneID:24099"
                     /db_xref="MGI:MGI:1344376"
ORIGIN      
        1 mdesaktlpp pclcfcsekg edmkvgydpi tpqkeegawf gicrdgrlla atlllallss
       61 sftamslyql aalqadlmnl rmelqsyrgs atpaaagape ltagvklltp aaprphnssr
      121 ghrnrrafqg peeteqdvdl sappapclpg crhsqhddng mnlrnrtytf vpwllsfkrg
      181 naleekenki vvrqtgyffi ysqvlytdpi famghviqrk kvhvfgdels lvtlfrciqn
      241 mpktlpnnsc ysagiarlee gdeiqlaipr enaqisrngd dtffgalkll
//
LOCUS       NP_001028603            1054 aa            linear   ROD 09-OCT-2023
DEFINITION  NACHT, LRR and PYD domains-containing protein 12 [Mus musculus].
ACCESSION   NP_001028603 XP_001476938 XP_909205
VERSION     NP_001028603.1
DBSOURCE    REFSEQ: accession NM_001033431.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1054)
  AUTHORS   Khan S, Kwak YT, Peng L, Hu S, Cantarel BL, Lewis CM, Gao Y, Mani
            RS, Kanneganti TD and Zaki H.
  TITLE     NLRP12 downregulates the Wnt/beta-catenin pathway via interaction
            with STK38 to suppress colorectal cancer
  JOURNAL   J Clin Invest 133 (19), e166295 (2023)
   PUBMED   37581937
  REMARK    GeneRIF: NLRP12 downregulates the Wnt/beta-catenin pathway via
            interaction with STK38 to suppress colorectal cancer.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1054)
  AUTHORS   Sharma BR, Karki R, Rajesh Y and Kanneganti TD.
  TITLE     Immune regulator IRF1 contributes to ZBP1-, AIM2-, RIPK1-, and
            NLRP12-PANoptosome activation and inflammatory cell death
            (PANoptosis)
  JOURNAL   J Biol Chem 299 (9), 105141 (2023)
   PUBMED   37557956
  REMARK    GeneRIF: Immune regulator IRF1 contributes to ZBP1-, AIM2-, RIPK1-,
            and NLRP12-PANoptosome activation and inflammatory cell death
            (PANoptosis).
REFERENCE   3  (residues 1 to 1054)
  AUTHORS   Abdelhamid L, Mao J, Cabana-Puig X, Zhu J, Swartwout BK, Edwards
            MR, Testerman JC, Michaelis JS, Allen IC, Ahmed SA and Luo XM.
  TITLE     Nlrp12 deficiency alters gut microbiota and ameliorates Faslpr
            -mediated systemic autoimmunity in male mice
  JOURNAL   Front Immunol 14, 1120958 (2023)
   PUBMED   36969209
  REMARK    GeneRIF: Nlrp12 deficiency alters gut microbiota and ameliorates
            Fas[lpr] -mediated systemic autoimmunity in male mice.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1054)
  AUTHORS   Tsao YP, Tseng FY, Chao CW, Chen MH, Yeh YC, Abdulkareem BO, Chen
            SY, Chuang WT, Chang PC, Chen IC, Wang PH, Wu CS, Tsai CY and Chen
            ST.
  TITLE     NLRP12 is an innate immune checkpoint for repressing IFN signatures
            and attenuating lupus nephritis progression
  JOURNAL   J Clin Invest 133 (3), e157272 (2023)
   PUBMED   36719379
  REMARK    GeneRIF: NLRP12 is an innate immune checkpoint for repressing IFN
            signatures and attenuating lupus nephritis progression.
            Erratum:[J Clin Invest. 2023 May 1;133(9):. PMID: 37115700]
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1054)
  AUTHORS   Lee EJ, Napier RJ, Vance EE, Lashley SJ, Truax AD, Ting JP and
            Rosenzweig HL.
  TITLE     The innate immune receptor Nlrp12 suppresses autoimmunity to the
            retina
  JOURNAL   J Neuroinflammation 19 (1), 69 (2022)
   PUBMED   35313917
  REMARK    GeneRIF: The innate immune receptor Nlrp12 suppresses autoimmunity
            to the retina.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1054)
  AUTHORS   Allen IC, Lich JD, Arthur JC, Jania CM, Roberts RA, Callaway JB,
            Tilley SL and Ting JP.
  TITLE     Characterization of NLRP12 during the development of allergic
            airway disease in mice
  JOURNAL   PLoS One 7 (1), e30612 (2012)
   PUBMED   22291998
  REMARK    GeneRIF: NLRP12 does not play a vital role in regulating Th2 driven
            airway inflammation using common model systems that are
            physiologically relevant to human disease.
REFERENCE   7  (residues 1 to 1054)
  AUTHORS   Zaki MH, Vogel P, Malireddi RK, Body-Malapel M, Anand PK, Bertin J,
            Green DR, Lamkanfi M and Kanneganti TD.
  TITLE     The NOD-like receptor NLRP12 attenuates colon inflammation and
            tumorigenesis
  JOURNAL   Cancer Cell 20 (5), 649-660 (2011)
   PUBMED   22094258
  REMARK    GeneRIF: NLRP12 has a critical role in maintaining intestinal
            homeostasis and providing protection against colorectal
            tumorigenesis.
REFERENCE   8  (residues 1 to 1054)
  AUTHORS   Elinav E, Strowig T, Kau AL, Henao-Mejia J, Thaiss CA, Booth CJ,
            Peaper DR, Bertin J, Eisenbarth SC, Gordon JI and Flavell RA.
  TITLE     NLRP6 inflammasome regulates colonic microbial ecology and risk for
            colitis
  JOURNAL   Cell 145 (5), 745-757 (2011)
   PUBMED   21565393
REFERENCE   9  (residues 1 to 1054)
  AUTHORS   Arthur JC, Lich JD, Ye Z, Allen IC, Gris D, Wilson JE, Schneider M,
            Roney KE, O'Connor BP, Moore CB, Morrison A, Sutterwala FS, Bertin
            J, Koller BH, Liu Z and Ting JP.
  TITLE     Cutting edge: NLRP12 controls dendritic and myeloid cell migration
            to affect contact hypersensitivity
  JOURNAL   J Immunol 185 (8), 4515-4519 (2010)
   PUBMED   20861349
  REMARK    GeneRIF: NLRP12 is important in maintaining neutrophils and
            peripheral DCs in a migration-competent state
REFERENCE   10 (residues 1 to 1054)
  AUTHORS   Hornung V, Ablasser A, Charrel-Dennis M, Bauernfeind F, Horvath G,
            Caffrey DR, Latz E and Fitzgerald KA.
  TITLE     AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating
            inflammasome with ASC
  JOURNAL   Nature 458 (7237), 514-518 (2009)
   PUBMED   19158675
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC245272.2.
            
            On or before Sep 10, 2009 this sequence version replaced
            XP_909205.3, XP_001476938.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164135
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1054
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 1.88 cM"
     Protein         1..1054
                     /product="NACHT, LRR and PYD domains-containing protein
                     12"
                     /note="PYRIN-containing APAF1-like protein 7"
                     /calculated_mol_wt=119188
     Region          12..87
                     /region_name="PYRIN"
                     /note="PAAD/DAPIN/Pyrin domain; pfam02758"
                     /db_xref="CDD:426964"
     Region          129..200
                     /region_name="FISNA"
                     /note="Fish-specific NACHT associated domain; pfam14484"
                     /db_xref="CDD:433982"
     Region          211..380
                     /region_name="NACHT"
                     /note="NACHT domain; pfam05729"
                     /db_xref="CDD:428606"
     Region          459..512
                     /region_name="NOD2_WH"
                     /note="NOD2 winged helix domain; pfam17779"
                     /db_xref="CDD:436037"
     Region          514..621
                     /region_name="NLRC4_HD2"
                     /note="NLRC4 helical domain HD2; pfam17776"
                     /db_xref="CDD:436035"
     Region          708..736
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          737..1028
                     /region_name="LRR_RI"
                     /note="Leucine-rich repeats (LRRs), ribonuclease inhibitor
                     (RI)-like subfamily. LRRs are 20-29 residue sequence
                     motifs present in many proteins that participate in
                     protein-protein interactions and have different functions
                     and cellular locations. LRRs correspond...; cd00116"
                     /db_xref="CDD:238064"
     Site            order(737,740,742,745,747,765,768,770,773,775,794,797,799,
                     802,804,822,825,827,830,832,851,854,856,859,861,879,882,
                     884,887,889,908,911,913,916,918,936,939,941,944,946,965,
                     968,970,973,975,993,996,998,1001,1003,1022,1025,1027)
                     /site_type="active"
                     /note="Leucine-rich repeats [active]"
                     /db_xref="CDD:238064"
     Region          737..764
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            order(743..744,801,858,886,943,969,971,997,1026)
                     /site_type="other"
                     /note="Substrate binding site [chemical binding]"
                     /db_xref="CDD:238064"
     Region          765..793
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          794..821
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          821..841
                     /region_name="LRR 1"
                     /note="propagated from UniProtKB/Swiss-Prot (E9Q5R7.1)"
     Region          822..850
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          850..871
                     /region_name="LRR 2"
                     /note="propagated from UniProtKB/Swiss-Prot (E9Q5R7.1)"
     Region          851..878
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          878..899
                     /region_name="LRR 3"
                     /note="propagated from UniProtKB/Swiss-Prot (E9Q5R7.1)"
     Region          879..907
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          907..928
                     /region_name="LRR 4"
                     /note="propagated from UniProtKB/Swiss-Prot (E9Q5R7.1)"
     Region          908..935
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          935..955
                     /region_name="LRR 5"
                     /note="propagated from UniProtKB/Swiss-Prot (E9Q5R7.1)"
     Region          964..985
                     /region_name="LRR 6"
                     /note="propagated from UniProtKB/Swiss-Prot (E9Q5R7.1)"
     Region          965..985
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          992..1013
                     /region_name="LRR 7"
                     /note="propagated from UniProtKB/Swiss-Prot (E9Q5R7.1)"
     Region          1021..1042
                     /region_name="LRR 8"
                     /note="propagated from UniProtKB/Swiss-Prot (E9Q5R7.1)"
     CDS             1..1054
                     /gene="Nlrp12"
                     /gene_synonym="monarch-1; Nalp12; PYPAF7"
                     /coded_by="NM_001033431.1:202..3366"
                     /db_xref="CCDS:CCDS51963.1"
                     /db_xref="GeneID:378425"
                     /db_xref="MGI:MGI:2676630"
ORIGIN      
        1 mlpstardgl yrlstyleel eagelkkfkl flgiaedlsq dkipwgrmek agplemaqlm
       61 vahmgtreaw llalstfqri hrkdlwergq gedlvrvtpn nglclfesqs acpldvspna
      121 prkdlqttyk dyvrrkfqlm edrnarlgec vnlsnrytrl llvkehsnpi wtqqkfvdve
      181 wersrtrrhq tspiqmetlf epdeerpepp htvvlqgaag mgksmlahkv mldwadgrlf
      241 qgrfdyvfyi screlnrsht qcsvqdliss cwpergisle dlmqapdrll fiidgfdklh
      301 psfhdaqgpw clcweekqpt evllgslirr lllpqvslli ttrpcalekl hgllehprhv
      361 eilgfseear keyfyryfhn tgqasrvlsf lmdyeplftm cfvpmvswvv ctclkqqles
      421 gellrqtprt ttavymfyll slmqpkpgtp tfkvpanqrg lvslaaeglw nqkilfdeqd
      481 lgkhgldgad vstflnvnif qkgikcekfy sfihlsfqef faamycalng reavrralae
      541 ygfsernfla ltvhflfgll neemrcyler nlgwsispqv keevlawiqn kagsegstlq
      601 hgslellscl yevqeedfiq qalshfqvvv vrsistkmeh mvcsfcaryc rstevlhlhg
      661 saystgmedd ppepsgvqtq stylqernml pdvysaylsa avctnsnlie lalyrnalgs
      721 qgvrllcqgl rhascklqnl rlkrcqisgs acqdlaaavi anrnlirldl sdnsigvpgl
      781 ellceglqhp rcrlqmiqlr kclleaaagr slasvlsnns ylveldltgn pledsglkll
      841 cqglrhpvcr lrtlwlkich lgqascedla stlkmnqsll eldlglndlg dsgvlllceg
      901 lshpdcklqt lrlgicrlgs vacvgiasvl qvntclqeld lsfndlgdrg lqllgeglrh
      961 qtcrlqklwl dncgltskac edlssilgis qtlhelyltn nalgdtgvcl lckrlrhpgc
     1021 klrvlwlfgm dlnkkthrrm aalrvtkpyl digc
//
LOCUS       NP_001103674             509 aa            linear   ROD 09-OCT-2023
DEFINITION  activin receptor type-1 precursor [Mus musculus].
ACCESSION   NP_001103674
VERSION     NP_001103674.1
DBSOURCE    REFSEQ: accession NM_001110204.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 509)
  AUTHORS   Yang YS, Lin C, Ma H, Xie J, Kaplan FS, Gao G and Shim JH.
  TITLE     AAV-Mediated Targeting of the Activin A-ACVR1R206H Signaling in
            Fibrodysplasia Ossificans Progressiva
  JOURNAL   Biomolecules 13 (9), 1364 (2023)
   PUBMED   37759764
  REMARK    GeneRIF: AAV-Mediated Targeting of the Activin A-ACVR1[R206H]
            Signaling in Fibrodysplasia Ossificans Progressiva.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 509)
  AUTHORS   Yamaguchi H, Shen J, Little DR, Li M, Sozen S, Suzuki K, Mishina Y
            and Komatsu Y.
  TITLE     Enhanced BMP signaling through ALK2 attenuates keratinocyte
            differentiation
  JOURNAL   Biochem Biophys Res Commun 629, 101-105 (2022)
   PUBMED   36116371
  REMARK    GeneRIF: Enhanced BMP signaling through ALK2 attenuates
            keratinocyte differentiation.
REFERENCE   3  (residues 1 to 509)
  AUTHORS   Yamamoto M, Stoessel SJ, Yamamoto S and Goldhamer DJ.
  TITLE     Overexpression of Wild-Type ACVR1 in Fibrodysplasia Ossificans
            Progressiva Mice Rescues Perinatal Lethality and Inhibits
            Heterotopic Ossification
  JOURNAL   J Bone Miner Res 37 (11), 2077-2093 (2022)
   PUBMED   35637634
  REMARK    GeneRIF: Overexpression of Wild-Type ACVR1 in Fibrodysplasia
            Ossificans Progressiva Mice Rescues Perinatal Lethality and
            Inhibits Heterotopic Ossification.
REFERENCE   4  (residues 1 to 509)
  AUTHORS   Lees-Shepard JB, Stoessel SJ, Chandler JT, Bouchard K, Bento P,
            Apuzzo LN, Devarakonda PM, Hunter JW and Goldhamer DJ.
  TITLE     An anti-ACVR1 antibody exacerbates heterotopic ossification by
            fibro-adipogenic progenitors in fibrodysplasia ossificans
            progressiva mice
  JOURNAL   J Clin Invest 132 (12) (2022)
   PUBMED   35503416
REFERENCE   5  (residues 1 to 509)
  AUTHORS   Chen HY, Hu Y, Xu XB, Zhou YA, Li NS, He C, Xie C, Lu NH and Zhu Y.
  TITLE     Upregulation of oncogene Activin A receptor type I by Helicobacter
            pylori infection promotes gastric intestinal metaplasia via
            regulating CDX2
  JOURNAL   Helicobacter 26 (6), e12849 (2021)
   PUBMED   34490965
  REMARK    GeneRIF: Upregulation of oncogene Activin A receptor type I by
            Helicobacter pylori infection promotes gastric intestinal
            metaplasia via regulating CDX2.
REFERENCE   6  (residues 1 to 509)
  AUTHORS   Schmitt J, Mielke R and Schrewe H.
  TITLE     Genomic organization of a mouse type I activin receptor
  JOURNAL   Biochem Biophys Res Commun 213 (1), 211-217 (1995)
   PUBMED   7639738
REFERENCE   7  (residues 1 to 509)
  AUTHORS   Verschueren K, Dewulf N, Goumans MJ, Lonnoy O, Feijen A, Grimsby S,
            Vandi Spiegle K, ten Dijke P, Moren A, Vanscheeuwijck P, Heldin CH,
            Miyazono K, Mummery C, Van Den Eijnden-Van Raaij J and Huylebroeck
            D.
  TITLE     Expression of type I and type IB receptors for activin in
            midgestation mouse embryos suggests distinct functions in
            organogenesis
  JOURNAL   Mech Dev 52 (1), 109-123 (1995)
   PUBMED   7577669
REFERENCE   8  (residues 1 to 509)
  AUTHORS   Roelen BA, Lin HY, Knezevic V, Freund E and Mummery CL.
  TITLE     Expression of TGF-beta s and their receptors during implantation
            and organogenesis of the mouse embryo
  JOURNAL   Dev Biol 166 (2), 716-728 (1994)
   PUBMED   7813789
REFERENCE   9  (residues 1 to 509)
  AUTHORS   Nakamura T, Sugino K, Kurosawa N, Sawai M, Takio K, Eto Y, Iwashita
            S, Muramatsu M, Titani K and Sugino H.
  TITLE     Isolation and characterization of activin receptor from mouse
            embryonal carcinoma cells. Identification of its
            serine/threonine/tyrosine protein kinase activity
  JOURNAL   J Biol Chem 267 (26), 18924-18928 (1992)
   PUBMED   1326537
REFERENCE   10 (residues 1 to 509)
  AUTHORS   Mathews LS and Vale WW.
  TITLE     Expression cloning of an activin receptor, a predicted
            transmembrane serine kinase
  JOURNAL   Cell 65 (6), 973-982 (1991)
   PUBMED   1646080
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK150014.1, AK053428.1, BC058718.1 and BQ030975.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. All five variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK053428.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 33.05 cM"
     Protein         1..509
                     /product="activin receptor type-1 precursor"
                     /EC_number="2.7.11.30"
                     /note="activin receptor type-1; TSR-I; TSK-7L; activin
                     receptor type I; TGF-B superfamily receptor type I;
                     serine/threonine-protein kinase receptor R1"
                     /calculated_mol_wt=55077
     sig_peptide     1..20
                     /note="/evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (P37172.2)"
                     /calculated_mol_wt=2167
     mat_peptide     21..509
                     /product="Activin receptor type-1. /id=PRO_0000024395"
                     /note="propagated from UniProtKB/Swiss-Prot (P37172.2)"
                     /calculated_mol_wt=55077
     Region          33..103
                     /region_name="Activin_recp"
                     /note="Activin types I and II receptor domain; pfam01064"
                     /db_xref="CDD:426025"
     Site            102
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P37172.2)"
     Site            124..146
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P37172.2)"
     Region          179..206
                     /region_name="TGF_beta_GS"
                     /note="Transforming growth factor beta type I GS-motif;
                     pfam08515"
                     /db_xref="CDD:430045"
     Region          202..499
                     /region_name="STKc_ACVR1_ALK1"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     Activin Type I Receptor and Activin receptor-Like Kinase
                     1; cd14142"
                     /db_xref="CDD:271044"
     Site            order(202..203,206..207,245..246,249..250,253..254,268,
                     270)
                     /site_type="other"
                     /note="FKBP12 binding site [polypeptide binding]"
                     /db_xref="CDD:271044"
     Site            order(214..218,222,233,235,263,283..286,290,292,336,338,
                     340..341,343,354,357,377..380)
                     /site_type="active"
                     /db_xref="CDD:271044"
     Site            order(214..220,222,233,235,283..284,286,290,340..341,343,
                     354)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271044"
     Site            order(218,290,292,336,338,340,357,377..380)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:271044"
     Site            353..380
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:271044"
     Site            501
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04771; propagated from
                     UniProtKB/Swiss-Prot (P37172.2)"
     CDS             1..509
                     /gene="Acvr1"
                     /gene_synonym="ActR-I; ActRIA; Acvr; Acvr1a; Acvrlk2;
                     Alk-2; ALK2; Alk8; D330013D15Rik; SKR1; Tsk7L"
                     /coded_by="NM_001110204.1:668..2197"
                     /db_xref="CCDS:CCDS16050.1"
                     /db_xref="GeneID:11477"
                     /db_xref="MGI:MGI:87911"
ORIGIN      
        1 mvdgvmilpv lmmmafpsps vedekpkvnq klymcvcegl scgnedhceg qqcfsslsin
       61 dgfhvyqkgc fqvyeqgkmt cktppspgqa veccqgdwcn rnitaqlptk gksfpgtqnf
      121 hlevgliils vvfavcllac ilgvalrkfk rrnqerlnpr dveygtiegl ittnvgdstl
      181 aelldhscts gsgsglpflv qrtvarqitl lecvgkgryg evwrgswqge nvavkifssr
      241 dekswfrete lyntvmlrhe nilgfiasdm tsrhsstqlw lithyhemgs lydylqlttl
      301 dtvsclrivl siasglahlh ieifgtqgks aiahrdlksk nilvkkngqc ciadlglavm
      361 hsqstnqldv gnnprvgtkr ymapevldet iqvdcfdsyk rvdiwafglv lwevarrmvs
      421 ngivedykpp fydvvpndps fedmrkvvcv dqqrpnipnr wfsdptltsl aklmkecwyq
      481 npsarltalr ikktltkidn sldklktdc
//
LOCUS       NP_001263342            2176 aa            linear   ROD 09-OCT-2023
DEFINITION  fibronectin isoform g precursor [Mus musculus].
ACCESSION   NP_001263342
VERSION     NP_001263342.1
DBSOURCE    REFSEQ: accession NM_001276413.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 2176)
  AUTHORS   Huo X, Ma S, Wang C, Song L, Yao B, Zhu S, Li P, Wang L, Wu Z and
            Wang K.
  TITLE     Unravelling the role of immune cells and FN1 in the recurrence and
            therapeutic process of skull base chordoma
  JOURNAL   Clin Transl Med 13 (10), e1429 (2023)
   PUBMED   37784253
  REMARK    GeneRIF: Unravelling the role of immune cells and FN1 in the
            recurrence and therapeutic process of skull base chordoma.
REFERENCE   2  (residues 1 to 2176)
  AUTHORS   Whisler J, Shahreza S, Schlegelmilch K, Ege N, Javanmardi Y,
            Malandrino A, Agrawal A, Fantin A, Serwinski B, Azizgolshani H,
            Park C, Shone V, Demuren OO, Del Rosario A, Butty VL, Holroyd N,
            Domart MC, Hooper S, Szita N, Boyer LA, Walker-Samuel S, Djordjevic
            B, Sheridan GK, Collinson L, Calvo F, Ruhrberg C, Sahai E, Kamm R
            and Moeendarbary E.
  TITLE     Emergent mechanical control of vascular morphogenesis
  JOURNAL   Sci Adv 9 (32), eadg9781 (2023)
   PUBMED   37566656
REFERENCE   3  (residues 1 to 2176)
  AUTHORS   Jena SK, Das S, Chakraborty S and Ain R.
  TITLE     Molecular determinants of epithelial mesenchymal transition in
            mouse placenta and trophoblast stem cell
  JOURNAL   Sci Rep 13 (1), 10978 (2023)
   PUBMED   37414855
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 2176)
  AUTHORS   Hiver S, Shimizu-Mizuno N, Ikawa Y, Kajikawa E, Sai X, Nishimura H,
            Takaoka K, Nishimura O, Kuraku S, Tanaka S and Hamada H.
  TITLE     Gse1, a component of the CoREST complex, is required for placenta
            development in the mouse
  JOURNAL   Dev Biol 498, 97-105 (2023)
   PUBMED   37019373
REFERENCE   5  (residues 1 to 2176)
  AUTHORS   Ozguldez HO, Govindasamy N, Fan R, Long H, Mildner K, Zeuschner D,
            Trappmann B, Ranga A and Bedzhov I.
  TITLE     Polarity inversion reorganizes the stem cell compartment of the
            trophoblast lineage
  JOURNAL   Cell Rep 42 (4), 112313 (2023)
   PUBMED   36989113
REFERENCE   6  (residues 1 to 2176)
  AUTHORS   Saga Y, Yagi T, Ikawa Y, Sakakura T and Aizawa S.
  TITLE     Mice develop normally without tenascin
  JOURNAL   Genes Dev 6 (10), 1821-1831 (1992)
   PUBMED   1383086
REFERENCE   7  (residues 1 to 2176)
  AUTHORS   Khandjian EW, Salomon C, Leonard N, Tremblay S and Turler H.
  TITLE     Fibronectin gene expression in proliferating, quiescent, and
            SV40-infected mouse kidney cells
  JOURNAL   Exp Cell Res 202 (2), 464-470 (1992)
   PUBMED   1327855
REFERENCE   8  (residues 1 to 2176)
  AUTHORS   Vidal SM, Epstein DJ, Malo D, Weith A, Vekemans M and Gros P.
  TITLE     Identification and mapping of six microdissected genomic DNA probes
            to the proximal region of mouse chromosome 1
  JOURNAL   Genomics 14 (1), 32-37 (1992)
   PUBMED   1358796
REFERENCE   9  (residues 1 to 2176)
  AUTHORS   Malo D, Schurr E, Epstein DJ, Vekemans M, Skamene E and Gros P.
  TITLE     The host resistance locus Bcg is tightly linked to a group of
            cytoskeleton-associated protein genes that include villin and
            desmin
  JOURNAL   Genomics 10 (2), 356-364 (1991)
   PUBMED   1676979
REFERENCE   10 (residues 1 to 2176)
  AUTHORS   Wartiovaara,J., Leivo,I. and Vaheri,A.
  TITLE     Expression of the cell surface-associated glycoprotein,
            fibronectin, in the early mouse embryo
  JOURNAL   Dev Biol 69 (1), 247-257 (1979)
   PUBMED   376373
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ098561.1, AK147701.1, AK171339.1 and AC124821.5.
            
            Transcript Variant: This variant (7) lacks two in-frame exons and
            uses an alternate in-frame splice site in the coding region,
            compared to variant 1. The encoded isoform (g) is shorter than
            isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147701.1, BC145271.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2176
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 36.05 cM"
     Protein         1..2176
                     /product="fibronectin isoform g precursor"
                     /calculated_mol_wt=236943
     sig_peptide     1..27
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=2797
     Region          53..90
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain, approximately 40 residue
                     long with two conserved disulfide bridges. FN1 is one of
                     three types of internal repeats which combine to form
                     larger domains within fibronectin. Fibronectin, a plasma
                     protein that binds cell surfaces...; cd00061"
                     /db_xref="CDD:238018"
     Region          98..141
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          142..185
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          187..231
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          232..271
                     /region_name="fn1"
                     /note="Fibronectin type I domain; pfam00039"
                     /db_xref="CDD:425437"
     Region          308..347
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          353..401
                     /region_name="FN2"
                     /note="Fibronectin type 2 domain; smart00059"
                     /db_xref="CDD:128373"
     Site            order(364,366,371,385,392,398,400)
                     /site_type="active"
                     /note="putative gelatin-binding site [active]"
                     /db_xref="CDD:238019"
     Region          413..461
                     /region_name="FN2"
                     /note="Fibronectin type 2 domain; smart00059"
                     /db_xref="CDD:128373"
     Site            order(424,426,431,445,452,458,460)
                     /site_type="active"
                     /note="putative gelatin-binding site [active]"
                     /db_xref="CDD:238019"
     Region          470..513
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          518..560
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          561..604
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          619..688
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Region          726..797
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(797..798,800..801)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Site            order(810,871,886)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Region          811..882
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(887..888,890..891)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          907..987
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(984..985,987..988)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          997..1075
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(1073..1074,1076..1077)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1091..1158
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Region          1174..1257
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(1254..1255,1257..1258)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1267..1348
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Region          1358..1438
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Region          1450..1529
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(1525..1526,1528..1529)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1542..1622
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(1619..1620,1622..1623)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1632..1712
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(1709..1710,1712..1713)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1724..1803
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(1800..1801,1803..1804)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1813..1893
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Region          1909..1964
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Region          1995..2039
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          2040..2081
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          2083..2122
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain, approximately 40 residue
                     long with two conserved disulfide bridges. FN1 is one of
                     three types of internal repeats which combine to form
                     larger domains within fibronectin. Fibronectin, a plasma
                     protein that binds cell surfaces...; cd00061"
                     /db_xref="CDD:238018"
     CDS             1..2176
                     /gene="Fn1"
                     /gene_synonym="E330027I09; Fn; Fn-1"
                     /coded_by="NM_001276413.1:253..6783"
                     /note="isoform g precursor is encoded by transcript
                     variant 7"
                     /db_xref="CCDS:CCDS78607.1"
                     /db_xref="GeneID:14268"
                     /db_xref="MGI:MGI:95566"
ORIGIN      
        1 mlrgpgpgrl lllavlclgt svrcteagks krqaqqivqp qspvavsqsk pgcfdngkhy
       61 qinqqwerty lgnalvctcy ggsrgfnces kpepeetcfd kytgntykvg dtyerpkdsm
      121 iwdctcigag rgrisctian rcheggqsyk igdkwrrphe tggymleclc lgngkgewtc
      181 kpiaekcfdh aagtsyvvge twekpyqgwm mvdctclgeg ngritctsrn rcndqdtrts
      241 yrigdtwskk dnrgnllqcv ctgngrgewk cerhalqsas agsgsftdvr taiyqpqthp
      301 qpapyghcvt dsgvvysvgm qwlksqgnkq mlctclgngv scqetavtqt yggnsngepc
      361 vlpftyngrt fyscttegrq dghlwcstts nyeqdqkysf ctdhavlvqt rggnsngalc
      421 hfpflynnrn ytdctsegrr dnmkwcgttq nydadqkfgf cpmaaheeic ttnegvmyri
      481 gdqwdkqhdl ghmmrctcvg ngrgewacip ysqlrdqciv dditynvndt fhkrheeghm
      541 lnctcfgqgr grwkcdpidq cqdsetrtfy qigdswekfv hgvryqcycy grgigewhcq
      601 plqtypgttg pvqviitetp sqpnshpiqw napepshitk yilrwrpkts tgrwkeatip
      661 ghlnsytikg ltpgviyegq lisiqqyghr evtrfdftts astpvtsntv tgetapyspv
      721 vatsesvtei tassfvvswv sasdtvsgfr veyelseegd epqyldlpst atsvnipdll
      781 pgrkyivnvy qiseegkqsl ilstsqttap dappdptvdq vddtsivvrw srpqapitgy
      841 rivyspsveg sstelnlpet ansvtlsdlq pgvqynitiy aveenqestp vfiqqettgt
      901 prsdnvpppt dlqfveltdv kvtimwtppd svvsgyrvev lpvslpgehg qrlpvnrntf
      961 aeitglspgv tylfkvfavh qgresnplta qqttkldapt nlqfvnetdr tvlvtwtppr
     1021 ariagyrlta gltrggqpkq ynvgplasky plrnlqpgse ytvtlvavkg nqqspkatgv
     1081 fttlqplrsi ppyntevtet tivitwtpap rigfklgvrp sqggeaprev tsdsgsivvs
     1141 gltpgveyty tiqvlrdgqe rdapivnrvv tplspptnlh leanpdtgvl tvswersttp
     1201 ditgyrittt ptngqqgtsl eevvhadqss ctfenlnpgl eynvsvytvk ddkesapisd
     1261 tvvpavpppt dlrftnigpd tmrvtwappp sieltnllvr yspvkneedv aelsispsdn
     1321 avvltnllpg teylvsvssv yeqhesiplr grqktgldsp tgfdssdita nsftvhwvap
     1381 rapitgyiir hhaehsvgrp rqdrvppsrn sitltnlnpg teyvvsiiav ngreesppli
     1441 gqqatvsdip rdleviastp tslliswepp avsvryyrit ygetggnspv qeftvpgsks
     1501 tatinnikpg adytitlyav tgrgdspass kpvsinykte idkpsqmqvt dvqdnsisvr
     1561 wlpstspvtg yrvtttpkng lgpsktktas pdqtemtieg lqptveyvvs vyaqnrnges
     1621 qplvqtavtt ipaptnlkfs qvtptsftaq wiapsvqltg yrvrvnpkek tgpmkeinls
     1681 pdsssvivsg lmvatkyevs vyalkdtlts rpaqgvittl envspprrar vtdatettit
     1741 iswrtkteti tgfqvdaipa ngqtpvqrsi spdvrsytit glqpgtdyki hlytlndnar
     1801 sspviidast aidapsnlrf ltttpnsllv swqaprarit gyiikyekpg spprevvprp
     1861 rpgvteatit glepgteyti yvialknnqk sepligrkkt gqealsqtti swtpfqesse
     1921 yiiscqpvgt deeplqfqvp gtstsatltg ltrgvtynii vealqnqrrh kvreevvtvg
     1981 navseglnqp tddscfdpyt vshyaigeew erlsdagfkl tcqclgfgsg hfrcdsskwc
     2041 hdngvnykig ekwdrqgeng qrmsctclgn gkgefkcdph eatcyddgkt yhvgeqwqke
     2101 ylgaicsctc fggqrgwrcd ncrrpgaaep spdgttghty nqytqrynqr tntnvncpie
     2161 cfmpldvqad rddsre
//
LOCUS       NP_001351354             448 aa            linear   ROD 09-OCT-2023
DEFINITION  pro-neuregulin-1, membrane-bound isoform isoform 6 [Mus musculus].
ACCESSION   NP_001351354 XP_017168128
VERSION     NP_001351354.1
DBSOURCE    REFSEQ: accession NM_001364425.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 448)
  AUTHORS   Mikami Y, Iwase F, Ohshima D, Tomida T and Adachi-Akahane S.
  TITLE     Compensatory role of neuregulin-1 in diabetic cardiomyopathy
  JOURNAL   J Pharmacol Sci 153 (3), 130-141 (2023)
   PUBMED   37770154
  REMARK    GeneRIF: Compensatory role of neuregulin-1 in diabetic
            cardiomyopathy.
REFERENCE   2  (residues 1 to 448)
  AUTHORS   Qiao XY, Wang Y, Zhang W, Li Q, Liu C, Dao JJ, Qiao CM, Cui C, Shen
            YQ and Zhao WJ.
  TITLE     Involvement of CXCL10 in Neuronal Damage under the Condition of
            Spinal Cord Injury and the Potential Therapeutic Effect of Nrg1
  JOURNAL   J Integr Neurosci 22 (4), 96 (2023)
   PUBMED   37519170
  REMARK    GeneRIF: Involvement of CXCL10 in Neuronal Damage under the
            Condition of Spinal Cord Injury and the Potential Therapeutic
            Effect of Nrg1.
REFERENCE   3  (residues 1 to 448)
  AUTHORS   Liu H, Lu P, He S, Luo Y, Fang Y, Benkaci S, Wu B, Wang Y and Zhou
            B.
  TITLE     beta-Catenin regulates endocardial cushion growth by suppressing
            p21
  JOURNAL   Life Sci Alliance 6 (9), e202302163 (2023)
   PUBMED   37385754
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 448)
  AUTHORS   Kong L, Hassinan CW, Gerstner F, Buettner JM, Petigrow JB, Valdivia
            DO, Chan-Cortes MH, Mistri A, Cao A, McGaugh SA, Denton M, Brown S,
            Ross J, Schwab MH, Simon CM and Sumner CJ.
  TITLE     Boosting neuregulin 1 type-III expression hastens SMA motor axon
            maturation
  JOURNAL   Acta Neuropathol Commun 11 (1), 53 (2023)
   PUBMED   36997967
  REMARK    GeneRIF: Boosting neuregulin 1 type-III expression hastens SMA
            motor axon maturation.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 448)
  AUTHORS   Zhang X, Xiao G, Johnson C, Cai Y, Horowitz ZK, Mennicke C, Coffey
            R, Haider M, Threadgill D, Eliscu R, Oldham MC, Greenbaum A and
            Ghashghaei HT.
  TITLE     Bulk and mosaic deletions of Egfr reveal regionally defined
            gliogenesis in the developing mouse forebrain
  JOURNAL   iScience 26 (3), 106242 (2023)
   PUBMED   36915679
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 448)
  AUTHORS   Gassmann M, Casagranda F, Orioli D, Simon H, Lai C, Klein R and
            Lemke G.
  TITLE     Aberrant neural and cardiac development in mice lacking the ErbB4
            neuregulin receptor
  JOURNAL   Nature 378 (6555), 390-394 (1995)
   PUBMED   7477376
REFERENCE   7  (residues 1 to 448)
  AUTHORS   Meyer,D. and Birchmeier,C.
  TITLE     Multiple essential functions of neuregulin in development
  JOURNAL   Nature 378 (6555), 386-390 (1995)
   PUBMED   7477375
  REMARK    Erratum:[Nature 1995 Dec 14;378(6558):753]
REFERENCE   8  (residues 1 to 448)
  AUTHORS   Moscoso LM, Chu GC, Gautam M, Noakes PG, Merlie JP and Sanes JR.
  TITLE     Synapse-associated expression of an acetylcholine receptor-inducing
            protein, ARIA/heregulin, and its putative receptors, ErbB2 and
            ErbB3, in developing mammalian muscle
  JOURNAL   Dev Biol 172 (1), 158-169 (1995)
   PUBMED   7589796
REFERENCE   9  (residues 1 to 448)
  AUTHORS   Yang Y, Spitzer E, Meyer D, Sachs M, Niemann C, Hartmann G, Weidner
            KM, Birchmeier C and Birchmeier W.
  TITLE     Sequential requirement of hepatocyte growth factor and neuregulin
            in the morphogenesis and differentiation of the mammary gland
  JOURNAL   J Cell Biol 131 (1), 215-226 (1995)
   PUBMED   7559778
REFERENCE   10 (residues 1 to 448)
  AUTHORS   Ho WH, Armanini MP, Nuijens A, Phillips HS and Osheroff PL.
  TITLE     Sensory and motor neuron-derived factor. A novel heregulin variant
            highly expressed in sensory and motor neurons
  JOURNAL   J Biol Chem 270 (24), 14523-14532 (1995)
   PUBMED   7782315
  REMARK    Erratum:[J Biol Chem. 1995 Nov 3;270(44):26722. PMID: 7592900]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132407.3 and AC127374.4.
            
            On Jun 16, 2018 this sequence version replaced XP_017168128.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660825.169274.1,
                                           SRR14995048.255226.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..448
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 18.75 cM"
     Protein         1..448
                     /product="pro-neuregulin-1, membrane-bound isoform isoform
                     6"
                     /note="heregulin; type III neuregulin 1; type I neuregulin
                     1; pro-neuregulin-1, membrane-bound isoform"
                     /calculated_mol_wt=50012
     Region          75..430
                     /region_name="Neuregulin"
                     /note="Neuregulin family; pfam02158"
                     /db_xref="CDD:426627"
     CDS             1..448
                     /gene="Nrg1"
                     /gene_synonym="6030402G23Rik; ARIA; D230005F13Rik; GGF;
                     GGFII; Hgl; HRG; HRGalpha; NDF; Pro-NRG1; SMDF"
                     /coded_by="NM_001364425.1:1327..2673"
                     /note="isoform 6 is encoded by transcript variant 6"
                     /db_xref="GeneID:211323"
                     /db_xref="MGI:MGI:96083"
ORIGIN      
        1 mvkdlsnpsr ylckcpneft gdrcqnyvma sfykhlgief meaeelyqkr vltitgicia
       61 llvvgimcvv aycktkkqrq klhdrlrqsl rsernnmvni angphhpnpp penvqlvnqy
      121 vsknvisseh iverevetsf stshytstah hsttvtqtps hswsnghtes iiseshsvim
      181 mssvensrhs spaggprgrl hglggprecn sflrharetp dsyrdsphse ryvsamttpa
      241 rmspvdfhtp sspksppsem sppvssmtvs mpsvavspfv eeerplllvt pprlrekkyd
      301 hhpqqlnsfh hnpahqstsl ppsplrived eeyettqeye piqepikkvt nsrrakrtkp
      361 nghianrlem dsnpssvssn sesetederv gedtpflgiq nplaasleva pafrlaesrt
      421 npagrfstqe elqarlssvi anqdpiav
//
LOCUS       NP_001397700             526 aa            linear   ROD 09-OCT-2023
DEFINITION  amino acid transporter heavy chain SLC3A2 isoform b [Mus musculus].
ACCESSION   NP_001397700 XP_036017348
VERSION     NP_001397700.1
DBSOURCE    REFSEQ: accession NM_001410771.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 526)
  AUTHORS   Xiang P, Chen Q, Chen L, Lei J, Yuan Z, Hu H, Lu Y, Wang X, Wang T,
            Yu R, Zhang W, Zhang J, Yu C and Ma L.
  TITLE     Metabolite Neu5Ac triggers SLC3A2 degradation promoting vascular
            endothelial ferroptosis and aggravates atherosclerosis progression
            in ApoE-/-mice
  JOURNAL   Theranostics 13 (14), 4993-5016 (2023)
   PUBMED   37771765
  REMARK    GeneRIF: Metabolite Neu5Ac triggers SLC3A2 degradation promoting
            vascular endothelial ferroptosis and aggravates atherosclerosis
            progression in ApoE[-/-]mice.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 526)
  AUTHORS   Puris E, Saveleva L, de Sousa Maciel I, Kanninen KM, Auriola S and
            Fricker G.
  TITLE     Protein Expression of Amino Acid Transporters Is Altered in
            Isolated Cerebral Microvessels of 5xFAD Mouse Model of Alzheimer's
            Disease
  JOURNAL   Mol Neurobiol 60 (2), 732-748 (2023)
   PUBMED   36367657
  REMARK    GeneRIF: Protein Expression of Amino Acid Transporters Is Altered
            in Isolated Cerebral Microvessels of 5xFAD Mouse Model of
            Alzheimer's Disease.
REFERENCE   3  (residues 1 to 526)
  AUTHORS   Eom J, Choi J, Suh SS and Seo JB.
  TITLE     SLC3A2 and SLC7A2 Mediate the Exogenous Putrescine-Induced
            Adipocyte Differentiation
  JOURNAL   Mol Cells 45 (12), 963-975 (2022)
   PUBMED   36572564
  REMARK    GeneRIF: SLC3A2 and SLC7A2 Mediate the Exogenous Putrescine-Induced
            Adipocyte Differentiation.
REFERENCE   4  (residues 1 to 526)
  AUTHORS   Chen Q, Liu L and Ni S.
  TITLE     Screening of ferroptosis-related genes in sepsis-induced liver
            failure and analysis of immune correlation
  JOURNAL   PeerJ 10, e13757 (2022)
   PUBMED   35923893
  REMARK    GeneRIF: Screening of ferroptosis-related genes in sepsis-induced
            liver failure and analysis of immune correlation.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 526)
  AUTHORS   Salazar-Petres E, Pereira-Carvalho D, Lopez-Tello J and
            Sferruzzi-Perri AN.
  TITLE     Placental structure, function, and mitochondrial phenotype relate
            to fetal size in each fetal sex in micedagger
  JOURNAL   Biol Reprod 106 (6), 1292-1311 (2022)
   PUBMED   35293971
REFERENCE   6  (residues 1 to 526)
  AUTHORS   Rochelle JM, Watson ML, Oakey RJ and Seldin MF.
  TITLE     A linkage map of mouse chromosome 19: definition of comparative
            mapping relationships with human chromosomes 10 and 11 including
            the MEN1 locus
  JOURNAL   Genomics 14 (1), 26-31 (1992)
   PUBMED   1358795
REFERENCE   7  (residues 1 to 526)
  AUTHORS   Fowler KJ, Clouston WM, Fournier RE and Evans BA.
  TITLE     The relaxin gene is located on chromosome 19 in the mouse
  JOURNAL   FEBS Lett 292 (1-2), 183-186 (1991)
   PUBMED   1959604
REFERENCE   8  (residues 1 to 526)
  AUTHORS   Horlick KR, Cheng IC, Wong WT, Wakeland EK and Nick HS.
  TITLE     Mouse lipocortin I gene structure and chromosomal assignment: gene
            duplication and the origins of a gene family
  JOURNAL   Genomics 10 (2), 365-374 (1991)
   PUBMED   1676980
REFERENCE   9  (residues 1 to 526)
  AUTHORS   Chainani M, Sampsell B and Elliott RW.
  TITLE     Localization of the gene for plasma retinol binding protein to the
            distal half of mouse chromosome 19
  JOURNAL   Genomics 9 (2), 376-379 (1991)
   PUBMED   2004789
REFERENCE   10 (residues 1 to 526)
  AUTHORS   Levanon D, Hsieh CL, Francke U, Dawson PA, Ridgway ND, Brown MS and
            Goldstein JL.
  TITLE     cDNA cloning of human oxysterol-binding protein and localization of
            the gene to human chromosome 11 and mouse chromosome 19
  JOURNAL   Genomics 7 (1), 65-74 (1990)
   PUBMED   1970801
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC025794.9.
            
            On Aug 15, 2022 this sequence version replaced XP_036017348.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14777531.75074.1,
                                           ERR2680375.263532.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..526
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 5.44 cM"
     Protein         1..526
                     /product="amino acid transporter heavy chain SLC3A2
                     isoform b"
                     /note="antigen identified by monoclonal antibodies 4F2;
                     4F2 cell-surface antigen heavy chain; CD98 heavy chain;
                     type II transmembrane protein; CD98 antigen; solute
                     carrier family 3 member 2; amino acid transporter heavy
                     chain SLC3A2"
                     /calculated_mol_wt=58206
     Region          1..31
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P10852.1)"
     Site            2
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P08195; propagated from
                     UniProtKB/Swiss-Prot (P10852.1)"
     Site            5
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q794F9; propagated from
                     UniProtKB/Swiss-Prot (P10852.1)"
     Region          40..118
                     /region_name="SLC3A2_N"
                     /note="Solute carrier family 3 member 2 N-terminus;
                     pfam16028"
                     /db_xref="CDD:435083"
     Site            58
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19144319,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P10852.1)"
     Site            76..99
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P10852.1)"
     Region          100..429
                     /region_name="AmyAc_family"
                     /note="Alpha amylase catalytic domain family; cl38930"
                     /db_xref="CDD:453893"
     Site            166
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19349973,
                     ECO:0000269|PubMed:19656770; propagated from
                     UniProtKB/Swiss-Prot (P10852.1)"
     Site            order(205,240,242,273,332..333)
                     /site_type="active"
                     /db_xref="CDD:200451"
     Site            order(242,273,333)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:200451"
     Site            259
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19349973,
                     ECO:0000269|PubMed:19656770; propagated from
                     UniProtKB/Swiss-Prot (P10852.1)"
     Site            263
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P10852.1)"
     Site            300
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P08195; propagated from
                     UniProtKB/Swiss-Prot (P10852.1)"
     Site            301
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P10852.1)"
     Site            302
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P08195; propagated from
                     UniProtKB/Swiss-Prot (P10852.1)"
     Site            318
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000250|UniProtKB:P08195; propagated from
                     UniProtKB/Swiss-Prot (P10852.1)"
     Site            385
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19349973,
                     ECO:0000269|PubMed:19656770; propagated from
                     UniProtKB/Swiss-Prot (P10852.1)"
     Site            399
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19349973,
                     ECO:0000269|PubMed:19656770; propagated from
                     UniProtKB/Swiss-Prot (P10852.1)"
     Site            420
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P08195; propagated from
                     UniProtKB/Swiss-Prot (P10852.1)"
     Site            509
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P10852.1)"
     CDS             1..526
                     /gene="Slc3a2"
                     /gene_synonym="4F2; 4F2HC; Cd98; Ly-10; Ly-m10; Ly10;
                     Mdu1; Mgp-2hc; NACAE"
                     /coded_by="NM_001410771.1:250..1830"
                     /note="isoform b is encoded by transcript variant 3"
                     /db_xref="GeneID:17254"
                     /db_xref="MGI:MGI:96955"
ORIGIN      
        1 msqdtevdmk dvelnelepe kqpmnaadga aageknglvk ikvaedetea gvkftglske
       61 ellkvagspg wvrtrwalll lfwlgwlgml agavviivra prcrelpvqr wwhkgalyri
      121 gdlqafvgrd aggiaglksh leylstlkvk glvlgpihkn qkdeinetdl kqinptlgsq
      181 edfkdllqsa kkksihiild ltpnyqgqna wflpaqadiv atkmkealss wlqdgvdgfq
      241 frdvgklmna plylaewqni tknlsedrll iagtessdlq qivnilests dllltssyls
      301 nstftgerte slvtrflnat gsqwcswsvs qaglladfip dhllrlyqll lftlpgtpvf
      361 sygdelglqg alpgqpakap lmpwnessif hiprpvslnm tvkgqnedpg slltqfrrls
      421 dlrgkersll hgdfhalsss pdlfsyirhw dqnerylvvl nfrdsgrsar lgasnlpagi
      481 slpasaklll stdsarqsre edtslklenl slnpyeglll qfpfva
//
LOCUS       NP_001405795             224 aa            linear   ROD 09-OCT-2023
DEFINITION  DDRGK domain-containing protein 1 isoform b [Mus musculus].
ACCESSION   NP_001405795
VERSION     NP_001405795.1
DBSOURCE    REFSEQ: accession NM_001418866.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 224)
  AUTHORS   Yang X, Zhou T, Wang X, Xia Y, Cao X, Cheng X, Cao Y, Ma P, Ma H,
            Qin A and Zhao J.
  TITLE     Loss of DDRGK1 impairs IRE1alpha UFMylation in spondyloepiphyseal
            dysplasia
  JOURNAL   Int J Biol Sci 19 (15), 4709-4725 (2023)
   PUBMED   37781516
  REMARK    GeneRIF: Loss of DDRGK1 impairs IRE1alpha UFMylation in
            spondyloepiphyseal dysplasia.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 224)
  AUTHORS   Tandra V, Anderson T, Ayala JD, Weintraub NL, Singh N, Li H and Li
            J.
  TITLE     Ufmylation of UFBP1 Is Dispensable for Endoplasmic Reticulum Stress
            Response, Embryonic Development, and Cardiac and Intestinal
            Homeostasis
  JOURNAL   Cells 12 (15), 1923 (2023)
   PUBMED   37566002
  REMARK    GeneRIF: Ufmylation of UFBP1 Is Dispensable for Endoplasmic
            Reticulum Stress Response, Embryonic Development, and Cardiac and
            Intestinal Homeostasis.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 224)
  AUTHORS   Chen F, Sheng L, Zhou T, Yan L, Loveless R, Li H, Teng Y and Cai Y.
  TITLE     Loss of Ufl1/Ufbp1 in hepatocytes promotes liver pathological
            damage and carcinogenesis through activating mTOR signaling
  JOURNAL   J Exp Clin Cancer Res 42 (1), 110 (2023)
   PUBMED   37131258
  REMARK    GeneRIF: Loss of Ufl1/Ufbp1 in hepatocytes promotes liver
            pathological damage and carcinogenesis through activating mTOR
            signaling.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 224)
  AUTHORS   Li H, Yu Z, Niu Z, Cheng Y, Wei Z, Cai Y, Ma F, Hu L, Zhu J and
            Zhang W.
  TITLE     A neuroprotective role of Ufmylation through Atg9 in the aging
            brain of Drosophila
  JOURNAL   Cell Mol Life Sci 80 (5), 129 (2023)
   PUBMED   37086384
  REMARK    GeneRIF: A neuroprotective role of Ufmylation through Atg9 in the
            aging brain of Drosophila.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 224)
  AUTHORS   Weisz-Hubshman M, Egunsula AT, Dawson B, Castellon A, Jiang MM,
            Chen-Evenson Y, Zhiyin Y, Lee B and Bae Y.
  TITLE     DDRGK1 is required for the proper development and maintenance of
            the growth plate cartilage
  JOURNAL   Hum Mol Genet 31 (16), 2820-2830 (2022)
   PUBMED   35377455
REFERENCE   6  (residues 1 to 224)
  AUTHORS   Yoo HM, Kang SH, Kim JY, Lee JE, Seong MW, Lee SW, Ka SH, Sou YS,
            Komatsu M, Tanaka K, Lee ST, Noh DY, Baek SH, Jeon YJ and Chung CH.
  TITLE     Modification of ASC1 by UFM1 is crucial for ERalpha transactivation
            and breast cancer development
  JOURNAL   Mol Cell 56 (2), 261-274 (2014)
   PUBMED   25219498
REFERENCE   7  (residues 1 to 224)
  AUTHORS   Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H,
            Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T,
            Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P,
            Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ,
            Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD,
            Flicek P, Skarnes WC, Mallon AM and Parkinson H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (residues 1 to 224)
  AUTHORS   Lemaire K, Moura RF, Granvik M, Igoillo-Esteve M, Hohmeier HE,
            Hendrickx N, Newgard CB, Waelkens E, Cnop M and Schuit F.
  TITLE     Ubiquitin fold modifier 1 (UFM1) and its target UFBP1 protect
            pancreatic beta cells from ER stress-induced apoptosis
  JOURNAL   PLoS One 6 (4), e18517 (2011)
   PUBMED   21494687
  REMARK    GeneRIF: These data suggest that UFM1-UFBP1 participate in
            preventing endoplasmic reticulum stress-induced apoptosis in
            protein secretory cells.
            Publication Status: Online-Only
REFERENCE   9  (residues 1 to 224)
  AUTHORS   Wu J, Lei G, Mei M, Tang Y and Li H.
  TITLE     A novel C53/LZAP-interacting protein regulates stability of
            C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and
            modulates NF-kappaB signaling
  JOURNAL   J Biol Chem 285 (20), 15126-15136 (2010)
   PUBMED   20228063
REFERENCE   10 (residues 1 to 224)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL772162.4 and AL731707.12.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253014.711528.1,
                                           SRR13422600.222129.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164132 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..224
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 63.24 cM"
     Protein         1..224
                     /product="DDRGK domain-containing protein 1 isoform b"
                     /note="DDRGK domain-containing protein 1; UFM1-binding
                     protein 1 containing a PCI domain; UFM1-binding and PCI
                     domain-containing protein 1"
                     /calculated_mol_wt=26041
     Region          25..213
                     /region_name="DDRGK"
                     /note="DDRGK domain; pfam09756"
                     /db_xref="CDD:370664"
     CDS             1..224
                     /gene="Ddrgk1"
                     /gene_synonym="1110001I20Rik; 2600009E05Rik; Ufbp1"
                     /coded_by="NM_001418866.1:296..970"
                     /note="isoform b is encoded by transcript variant 3"
                     /db_xref="GeneID:77006"
                     /db_xref="MGI:MGI:1924256"
ORIGIN      
        1 mrmwvkllfq eeegiekpae vhptgkigak klrkleekqa rkaqreaeea ereerkrles
       61 qreaewkkee erlrlkeeqk eeeerkaqee qarreheeyl klkeafvvee egvsetmtee
      121 qshsfltefi nyikkskvvl ledlafqmgl rtqdainriq dlltegtltg viddrgkfiy
      181 itpeelaava nfirqrgrvs itelaqasns liswgqdlpa qasa
//
LOCUS       NP_001278103             702 aa            linear   ROD 09-OCT-2023
DEFINITION  nuclear factor of activated T-cells, cytoplasmic 2 isoform k [Mus
            musculus].
ACCESSION   NP_001278103 XP_006498956
VERSION     NP_001278103.1
DBSOURCE    REFSEQ: accession NM_001291174.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 702)
  AUTHORS   Fu Y, Wang J, Liu C, Liao K, Gao X, Tang R, Fan B, Hong Y, Xiao N,
            Xiao C and Liu WH.
  TITLE     Glycogen synthase kinase 3 controls T-cell exhaustion by regulating
            NFAT activation
  JOURNAL   Cell Mol Immunol 20 (10), 1127-1139 (2023)
   PUBMED   37553428
  REMARK    GeneRIF: Glycogen synthase kinase 3 controls T-cell exhaustion by
            regulating NFAT activation.
REFERENCE   2  (residues 1 to 702)
  AUTHORS   Wan X, Zhao S, Dai Y, Zhang J, Shen Y, Gong L and Le Q.
  TITLE     WNT16b promotes the proliferation and self-renewal of human limbal
            epithelial stem/progenitor cells via activating the
            calcium/calcineurin A/NFATC2 pathway
  JOURNAL   Cell Prolif 56 (10), e13460 (2023)
   PUBMED   36974338
  REMARK    GeneRIF: WNT16b promotes the proliferation and self-renewal of
            human limbal epithelial stem/progenitor cells via activating the
            calcium/calcineurin A/NFATC2 pathway.
REFERENCE   3  (residues 1 to 702)
  AUTHORS   Jiang F, Guo Y, Hu L, Zhang M, Meng J, Si Y and Shi H.
  TITLE     Role of nuclear factor of activated T Cells-1 in Sepsis-induced
            behavioral deficits in mice
  JOURNAL   Brain Res 1806, 148299 (2023)
   PUBMED   36842570
REFERENCE   4  (residues 1 to 702)
  AUTHORS   Nagai J, Lin J and Boyce JA.
  TITLE     Macrophage P2Y6 Receptor Signaling Selectively Activates NFATC2 and
            Suppresses Allergic Lung Inflammation
  JOURNAL   J Immunol 209 (12), 2293-2303 (2022)
   PUBMED   36307120
  REMARK    GeneRIF: Macrophage P2Y6 Receptor Signaling Selectively Activates
            NFATC2 and Suppresses Allergic Lung Inflammation.
REFERENCE   5  (residues 1 to 702)
  AUTHORS   Zhu L, Zhou X, Gu M, Kim J, Li Y, Ko CJ, Xie X, Gao T, Cheng X and
            Sun SC.
  TITLE     Dapl1 controls NFATc2 activation to regulate CD8+ T cell exhaustion
            and responses in chronic infection and cancer
  JOURNAL   Nat Cell Biol 24 (7), 1165-1176 (2022)
   PUBMED   35773432
REFERENCE   6  (residues 1 to 702)
  AUTHORS   Vihma H, Pruunsild P and Timmusk T.
  TITLE     Alternative splicing and expression of human and mouse NFAT genes
  JOURNAL   Genomics 92 (5), 279-291 (2008)
   PUBMED   18675896
REFERENCE   7  (residues 1 to 702)
  AUTHORS   Ho SN, Thomas DJ, Timmerman LA, Li X, Francke U and Crabtree GR.
  TITLE     NFATc3, a lymphoid-specific NFATc family member that is
            calcium-regulated and exhibits distinct DNA binding specificity
  JOURNAL   J Biol Chem 270 (34), 19898-19907 (1995)
   PUBMED   7650004
REFERENCE   8  (residues 1 to 702)
  AUTHORS   Jain J, Burgeon E, Badalian TM, Hogan PG and Rao A.
  TITLE     A similar DNA-binding motif in NFAT family proteins and the Rel
            homology region
  JOURNAL   J Biol Chem 270 (8), 4138-4145 (1995)
   PUBMED   7876165
REFERENCE   9  (residues 1 to 702)
  AUTHORS   Li X, Ho SN, Luna J, Giacalone J, Thomas DJ, Timmerman LA, Crabtree
            GR and Francke U.
  TITLE     Cloning and chromosomal localization of the human and murine genes
            for the T-cell transcription factors NFATc and NFATp
  JOURNAL   Cytogenet Cell Genet 68 (3-4), 185-191 (1995)
   PUBMED   7842733
REFERENCE   10 (residues 1 to 702)
  AUTHORS   Ho AM, Jain J, Rao A and Hogan PG.
  TITLE     Expression of the transcription factor NFATp in a neuronal cell
            line and in the murine nervous system
  JOURNAL   J Biol Chem 269 (45), 28181-28186 (1994)
   PUBMED   7961754
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK044489.1, EU887583.1 and BP757417.1.
            
            On Mar 27, 2014 this sequence version replaced XP_006498956.1.
            
            Transcript Variant: This variant (11, also known as IA-IIS-Xa)
            contains alternate 5' and 3' exon structure, and it thus differs in
            both UTRs, initiates translation at a downstream in-frame start
            codon, and differs in the 3' coding region, compared to variant 1.
            The encoded isoform (k) is shorter at the N-terminus and has a
            distinct C-terminus, compared to isoform a. Both variants 11 and 12
            encode isoform k.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU887583.1, SRR9219381.212114.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..702
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 88.91 cM"
     Protein         1..702
                     /product="nuclear factor of activated T-cells, cytoplasmic
                     2 isoform k"
                     /note="nuclear factor of activated T-cells, cytoplasmic 2;
                     NFAT pre-existing subunit; T-cell transcription factor
                     NFAT1"
                     /calculated_mol_wt=76458
     Region          179..353
                     /region_name="RHD-n_NFAT"
                     /note="N-terminal sub-domain of the Rel homology domain
                     (RHD) of nuclear factor of activated T-cells (NFAT)
                     proteins; cd07881"
                     /db_xref="CDD:143641"
     Site            order(202,205,207..208,210..212,260,301,303..304,318..319,
                     321,352)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143641"
     Region          358..458
                     /region_name="IPT_NFAT"
                     /note="IPT domain of the NFAT family of transcription
                     factors. NFAT transcription complexes are a target of
                     calcineurin, a calcium dependent phosphatase, and activate
                     genes mainly involved in cell-cell-interaction; cd01178"
                     /db_xref="CDD:238583"
     Site            order(382,446)
                     /site_type="DNA binding"
                     /note="DNA binding sites [nucleotide binding]"
                     /db_xref="CDD:238583"
     CDS             1..702
                     /gene="Nfatc2"
                     /gene_synonym="NF-ATc2; NF-ATp; NFAT1; NFAT1-D; Nfatp"
                     /coded_by="NM_001291174.1:203..2311"
                     /note="isoform k is encoded by transcript variant 11"
                     /db_xref="GeneID:18019"
                     /db_xref="MGI:MGI:102463"
ORIGIN      
        1 msprtslaed sclgrhspvp rpasrssspg akrrhscaea lvaplpaasp qrsrspspqp
       61 sphvalqdds ipagypptag savlmdalnt latdspcgip skiwktspdp tpvstapska
      121 glarhiyptv eflgpceqee rrnsapesil lvpptwpkql vpaipicsip vtaslpplew
      181 plsnqsgsye lrievqpkph hrahyetegs rgavkaptgg hpvvqlhgym enkplglqif
      241 igtaderilk phafyqvhri tgktvtttsy ekivgntkvl eiplepknnm ratidcagil
      301 klrnadielr kgetdigrkn trvrlvfrvh vpepsgrivs lqaasnpiec sqrsahelpm
      361 verqdmdscl vyggqqmilt gqnftaeskv vfmekttdgq qiwemeatvd kdksqpnmlf
      421 veipeyrnkh irvpvkvnfy vingkrkrsq pqhftyhpvp aiktepsdey epslicspah
      481 gglgsqpyyp qhpmlaesps clvatmapcq qfrsglsspd aryqqqspaa alyqrsksls
      541 pgllgyqqps llaaplglad ahrsvlvhag sqgqgqgstl phtssasqqa spvihysptn
      601 qqlrggghqe fqhimycenf gpssarpgpp pinqgqrlsp gayptviqqq tapsqraakn
      661 gpsdqkealp tgvtvkqeqn ldqtylddel idthlswiqn il
//
LOCUS       NP_032715                971 aa            linear   ROD 09-OCT-2023
DEFINITION  nuclear factor NF-kappa-B p105 subunit isoform 1 [Mus musculus].
ACCESSION   NP_032715
VERSION     NP_032715.2
DBSOURCE    REFSEQ: accession NM_008689.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 971)
  AUTHORS   Lin LL, Song GJ, Zhang H, Yin Y, Xin SM, Ding L and Li Y.
  TITLE     GPR34 Knockdown Relieves Cognitive Deficits and Suppresses
            Neuroinflammation in Alzheimer's Disease via the ERK/NF-kappaB
            Signal
  JOURNAL   Neuroscience 528, 129-139 (2023)
   PUBMED   37557947
  REMARK    GeneRIF: GPR34 Knockdown Relieves Cognitive Deficits and Suppresses
            Neuroinflammation in Alzheimer's Disease via the ERK/NF-kappaB
            Signal.
REFERENCE   2  (residues 1 to 971)
  AUTHORS   Harding O, Holzer E, Riley JF, Martens S and Holzbaur ELF.
  TITLE     Damaged mitochondria recruit the effector NEMO to activate
            NF-kappaB signaling
  JOURNAL   Mol Cell 83 (17), 3188-3204 (2023)
   PUBMED   37683611
  REMARK    GeneRIF: Damaged mitochondria recruit the effector NEMO to activate
            NF-kappaB signaling.
REFERENCE   3  (residues 1 to 971)
  AUTHORS   Zhuang L, Zong X, Yang Q, Fan Q and Tao R.
  TITLE     Interleukin-34-NF-kappaB signaling aggravates myocardial
            ischemic/reperfusion injury by facilitating macrophage recruitment
            and polarization
  JOURNAL   EBioMedicine 95, 104744 (2023)
   PUBMED   37556943
  REMARK    GeneRIF: Interleukin-34-NF-kappaB signaling aggravates myocardial
            ischemic/reperfusion injury by facilitating macrophage recruitment
            and polarization.
REFERENCE   4  (residues 1 to 971)
  AUTHORS   Mao W, Wang X, Zhang Y, Zhu H, Dai L and Chen J.
  TITLE     Nuclear factor-kappa B p50-induced microRNA-20a-3p plays a
            detrimental role in sepsis-induced acute kidney injury
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (8), 198-202 (2023)
   PUBMED   37715384
  REMARK    GeneRIF: Nuclear factor-kappa B p50-induced microRNA-20a-3p plays a
            detrimental role in sepsis-induced acute kidney injury.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 971)
  AUTHORS   Verma M, Verma D, Sripada AS, Sirohi K, Varma R, Sahu A and Alam R.
  TITLE     NFkappaB1 inhibits memory formation and supports effector function
            of ILC2s in memory-driven asthma
  JOURNAL   Front Immunol 14, 1217776 (2023)
   PUBMED   37575259
  REMARK    GeneRIF: NFkappaB1 inhibits memory formation and supports effector
            function of ILC2s in memory-driven asthma.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 971)
  AUTHORS   Wulczyn FG, Naumann M and Scheidereit C.
  TITLE     Candidate proto-oncogene bcl-3 encodes a subunit-specific inhibitor
            of transcription factor NF-kappa B
  JOURNAL   Nature 358 (6387), 597-599 (1992)
   PUBMED   1501714
REFERENCE   7  (residues 1 to 971)
  AUTHORS   Inoue J, Kerr LD, Kakizuka A and Verma IM.
  TITLE     I kappa B gamma, a 70 kd protein identical to the C-terminal half
            of p110 NF-kappa B: a new member of the I kappa B family
  JOURNAL   Cell 68 (6), 1109-1120 (1992)
   PUBMED   1339305
REFERENCE   8  (residues 1 to 971)
  AUTHORS   Ryseck RP, Bull P, Takamiya M, Bours V, Siebenlist U, Dobrzanski P
            and Bravo R.
  TITLE     RelB, a new Rel family transcription activator that can interact
            with p50-NF-kappa B
  JOURNAL   Mol Cell Biol 12 (2), 674-684 (1992)
   PUBMED   1732739
REFERENCE   9  (residues 1 to 971)
  AUTHORS   Nolan GP, Ghosh S, Liou HC, Tempst P and Baltimore D.
  TITLE     DNA binding and I kappa B inhibition of the cloned p65 subunit of
            NF-kappa B, a rel-related polypeptide
  JOURNAL   Cell 64 (5), 961-969 (1991)
   PUBMED   2001591
REFERENCE   10 (residues 1 to 971)
  AUTHORS   Ghosh S, Gifford AM, Riviere LR, Tempst P, Nolan GP and Baltimore
            D.
  TITLE     Cloning of the p50 DNA binding subunit of NF-kappa B: homology to
            rel and dorsal
  JOURNAL   Cell 62 (5), 1019-1029 (1990)
   PUBMED   2203532
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC101973.7 and AC110164.26.
            
            On Nov 8, 2006 this sequence version replaced NP_032715.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M57999.1, SRR13422586.332543.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..971
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 62.82 cM"
     Protein         1..971
                     /product="nuclear factor NF-kappa-B p105 subunit isoform
                     1"
                     /note="nuclear factor NF-kappa-B p105 subunit; EBP-1;
                     DNA-binding factor KBF1; NF-kappa-B1 p84/NF-kappa-B1 p98;
                     nuclear factor of kappa light chain gene enhancer in
                     B-cells 1, p105; NF kappaB1; NF-kappaB p50; p50 subunit of
                     NF kappaB; nuclear factor kappaB p50"
                     /calculated_mol_wt=105485
     Region          40..241
                     /region_name="RHD-n_NFkB1"
                     /note="N-terminal sub-domain of the Rel homology domain
                     (RHD) of nuclear factor of kappa B1 (NF-kappa B1);
                     cd07935"
                     /db_xref="CDD:143651"
     Site            order(54,56..57,59..60,63..66,141,143..144,241)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143651"
     Region          248..349
                     /region_name="IPT_NFkappaB"
                     /note="IPT domain of the transcription factor NFkappaB and
                     related transcription factors. NFkappaB is considered a
                     central regulator of stress responses, activated by
                     different stressful conditions, including physical stress,
                     oxidative stress, and exposure to...; cd01177"
                     /db_xref="CDD:238582"
     Site            order(249,251..253,255..257,297..299,312,324,343,346,348)
                     /site_type="other"
                     /note="ankyrin protein binding site [polypeptide binding]"
                     /db_xref="CDD:238582"
     Site            order(251..252,254,267,269,271,304..305,308,310)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:238582"
     Site            order(272,274,305..306)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238582"
     Site            335
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKA. /evidence=ECO:0000255;
                     propagated from UniProtKB/Swiss-Prot (P25799.2)"
     Region          358..363
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (P25799.2)"
     Region          370..392
                     /region_name="GRR. /evidence=ECO:0000250|UniProtKB:P19838"
                     /note="propagated from UniProtKB/Swiss-Prot (P25799.2)"
     Site            431..432
                     /site_type="cleavage"
                     /note="Cleavage (when cotranslationally processed).
                     /evidence=ECO:0000250|UniProtKB:P19838; propagated from
                     UniProtKB/Swiss-Prot (P25799.2)"
     Region          433..971
                     /region_name="Interaction with CFLAR.
                     /evidence=ECO:0000250|UniProtKB:P19838"
                     /note="propagated from UniProtKB/Swiss-Prot (P25799.2)"
     Site            438
                     /site_type="acetylation"
                     /note="N6-acetyllysine, by EP300.
                     /evidence=ECO:0000250|UniProtKB:P19838; propagated from
                     UniProtKB/Swiss-Prot (P25799.2)"
     Region          439..470
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P25799.2)"
     Site            447
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P25799.2)"
     Region          <534..608
                     /region_name="Ank_2"
                     /note="Ankyrin repeats (3 copies); pfam12796"
                     /db_xref="CDD:432791"
     Site            order(538,540,544..545,548..550,552..553,557,560,575,577,
                     579,583..584,587..589,591..592,596,599,608,610,612,
                     616..617,620..622,624..625,629,632)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          538..575
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          577..608
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          582..676
                     /region_name="Ank_2"
                     /note="Ankyrin repeats (3 copies); pfam12796"
                     /db_xref="CDD:432791"
     Site            order(646,648,652..653,656..658,660..661,665,668,677,680,
                     682,686..687,690..692,694..695,700,703,712,714,716,
                     720..721,724..726,728)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          646..680
                     /region_name="Essential for interaction with HIF1AN.
                     /evidence=ECO:0000250|UniProtKB:P19838"
                     /note="propagated from UniProtKB/Swiss-Prot (P25799.2)"
     Region          646..677
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          651..>727
                     /region_name="Ank_2"
                     /note="Ankyrin repeats (3 copies); pfam12796"
                     /db_xref="CDD:432791"
     Site            674
                     /site_type="hydroxylation"
                     /note="(3S)-3-hydroxyasparagine, by HIF1AN.
                     /evidence=ECO:0000250|UniProtKB:P19838; propagated from
                     UniProtKB/Swiss-Prot (P25799.2)"
     Region          680..712
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            755
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q63369; propagated from
                     UniProtKB/Swiss-Prot (P25799.2)"
     Region          812..886
                     /region_name="Death_NFkB1_p105"
                     /note="Death domain of the Nuclear Factor-KappaB1
                     precursor protein p105; cd08797"
                     /db_xref="CDD:260063"
     Site            896
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P19838; propagated from
                     UniProtKB/Swiss-Prot (P25799.2)"
     Site            910
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by GSK3-beta, in vitro.
                     /evidence=ECO:0000250|UniProtKB:P19838; propagated from
                     UniProtKB/Swiss-Prot (P25799.2)"
     Site            926
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P19838; propagated from
                     UniProtKB/Swiss-Prot (P25799.2)"
     Site            930
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by IKKB.
                     /evidence=ECO:0000250|UniProtKB:P19838; propagated from
                     UniProtKB/Swiss-Prot (P25799.2)"
     Site            935
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by IKKB.
                     /evidence=ECO:0000250|UniProtKB:P19838; propagated from
                     UniProtKB/Swiss-Prot (P25799.2)"
     Site            940
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P25799.2)"
     Site            946
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P25799.2)"
     CDS             1..971
                     /gene="Nfkb1"
                     /gene_synonym="NF-kappaB; NF-kappaB1; NF-KB1; p105; p50;
                     p50/p105"
                     /coded_by="NM_008689.3:421..3336"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS17858.1"
                     /db_xref="GeneID:18033"
                     /db_xref="MGI:MGI:97312"
ORIGIN      
        1 madddpygtg qmfhlntalt hsifnaelys peiplstdgp ylqileqpkq rgfrfryvce
       61 gpshgglpga sseknkksyp qvkicnyvgp akvivqlvtn gknihlhahs lvgkhcedgv
      121 ctvtagpkdm vvgfanlgil hvtkkkvfet learmteaci rgynpgllvh sdlaylqaeg
      181 ggdrqltdre keiirqaavq qtkemdlsvv rlmftaflpd stgsftrrle pvvsdaiyds
      241 kapnasnlki vrmdrtagcv tggeeiyllc dkvqkddiqi rfyeeeengg vwegfgdfsp
      301 tdvhrqfaiv fktpkykdvn itkpasvfvq lrrksdlets epkpflyype ikdkeevqrk
      361 rqklmpnfsd sfgggsgaga ggggmfgsgg gggstgspgp gygysnygfp pyggitfhpg
      421 vtksnagvth gtintkfkng pkdcaksdde esltlpeket egegpslpma ctktepiala
      481 stmedkeqdm gfqdnlflek alqlarrhan alfdyavtgd vkmllavqrh ltavqdengd
      541 svlhlaiihl haqlvrdlle vtsglisddi inmrndlyqt plhlavitkq edvvedllrv
      601 gadlslldrw gnsvlhlaak eghdrilsil lksrkaapli dhpngeglna ihiavmsnsl
      661 pcllllvaag aevnaqeqks grtalhlave ydnislagcl llegdahvds ttydgttplh
      721 iaagrgstrl aallkaagad plvenfeply dlddswekag edegvvpgtt pldmaanwqv
      781 fdilngkpye pvftsddilp qgdmkqlted trlqlcklle ipdpdknwat laqklglgil
      841 nnafrlspap sktlmdnyev sggtikelme alqqmgytea ieviqaafrt pattasspvt
      901 taqvhclpls ssstrqhide lrdsdsvcds gvetsfrkls ftesltgdsp llslnkmphg
      961 ygqegpiegk i
//
LOCUS       NP_034815                415 aa            linear   ROD 09-OCT-2023
DEFINITION  lysosome-associated membrane glycoprotein 2 isoform 2 precursor
            [Mus musculus].
ACCESSION   NP_034815
VERSION     NP_034815.2
DBSOURCE    REFSEQ: accession NM_010685.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 415)
  AUTHORS   Liu D, Xing R, Zhang Q, Tian X, Qi Y, Song H, Liu Y, Yu H, Zhang X,
            Jing Q, Yan C and Han Y.
  TITLE     The CREG1-FBXO27-LAMP2 axis alleviates diabetic cardiomyopathy by
            promoting autophagy in cardiomyocytes
  JOURNAL   Exp Mol Med 55 (9), 2025-2038 (2023)
   PUBMED   37658156
  REMARK    GeneRIF: The CREG1-FBXO27-LAMP2 axis alleviates diabetic
            cardiomyopathy by promoting autophagy in cardiomyocytes.
REFERENCE   2  (residues 1 to 415)
  AUTHORS   Wang Y, Hang K, Ying L, Wu J, Wu X, Zhang W, Li L, Wang Z, Bai J,
            Gao X, Xue D and Pan Z.
  TITLE     LAMP2A regulates the balance of mesenchymal stem cell
            adipo-osteogenesis via the Wnt/beta-catenin/GSK3beta signaling
            pathway
  JOURNAL   J Mol Med (Berl) 101 (7), 783-799 (2023)
   PUBMED   37162558
  REMARK    GeneRIF: LAMP2A regulates the balance of mesenchymal stem cell
            adipo-osteogenesis via the Wnt/beta-catenin/GSK3beta signaling
            pathway.
REFERENCE   3  (residues 1 to 415)
  AUTHORS   Zhang KK, Zhang P, Kodur A, Erturk I, Burns CM, Kenyon C, Miller RA
            and Endicott SJ.
  TITLE     LAMP2A, and other chaperone-mediated autophagy related proteins, do
            not decline with age in genetically heterogeneous UM-HET3 mice
  JOURNAL   Aging (Albany NY) 15 (11), 4685-4698 (2023)
   PUBMED   37315291
  REMARK    GeneRIF: LAMP2A, and other chaperone-mediated autophagy related
            proteins, do not decline with age in genetically heterogeneous
            UM-HET3 mice.
REFERENCE   4  (residues 1 to 415)
  AUTHORS   Maglica M, Kelam N, Haque E, Perutina I, Racetin A, Filipovic N,
            Katsuyama Y and Vukojevic K.
  TITLE     Immunoexpression Pattern of Autophagy Markers in Developing and
            Postnatal Kidneys of Dab1-/-(yotari) Mice
  JOURNAL   Biomolecules 13 (3), 402 (2023)
   PUBMED   36979337
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 415)
  AUTHORS   Sutton KA and Wilkinson MF.
  TITLE     The rapidly evolving Pem homeobox gene and Agtr2, Ant2, and Lamp2
            are closely linked in the proximal region of the mouse X chromosome
  JOURNAL   Genomics 45 (2), 447-450 (1997)
   PUBMED   9344676
REFERENCE   6  (residues 1 to 415)
  AUTHORS   Cella N, Cornejo-Uribe RR, Montes GS, Hynes NE and Chammas R.
  TITLE     The lysosomal-associated membrane protein LAMP-1 is a novel
            differentiation marker for HC11 mouse mammary epithelial cells
  JOURNAL   Differentiation 61 (2), 113-120 (1996)
   PUBMED   8983177
REFERENCE   7  (residues 1 to 415)
  AUTHORS   Gough NR, Hatem CL and Fambrough DM.
  TITLE     The family of LAMP-2 proteins arises by alternative splicing from a
            single gene: characterization of the avian LAMP-2 gene and
            identification of mammalian homologs of LAMP-2b and LAMP-2c
  JOURNAL   DNA Cell Biol 14 (10), 863-867 (1995)
   PUBMED   7546292
REFERENCE   8  (residues 1 to 415)
  AUTHORS   Dardik A, Smith RM and Schultz RM.
  TITLE     Colocalization of transforming growth factor-alpha and a functional
            epidermal growth factor receptor (EGFR) to the inner cell mass and
            preferential localization of the EGFR on the basolateral surface of
            the trophectoderm in the mouse blastocyst
  JOURNAL   Dev Biol 154 (2), 396-409 (1992)
   PUBMED   1426645
REFERENCE   9  (residues 1 to 415)
  AUTHORS   Granger BL, Green SA, Gabel CA, Howe CL, Mellman I and Helenius A.
  TITLE     Characterization and cloning of lgp110, a lysosomal membrane
            glycoprotein from mouse and rat cells
  JOURNAL   J Biol Chem 265 (20), 12036-12043 (1990)
   PUBMED   2142158
REFERENCE   10 (residues 1 to 415)
  AUTHORS   Cha Y, Holland SM and August JT.
  TITLE     The cDNA sequence of mouse LAMP-2. Evidence for two classes of
            lysosomal membrane glycoproteins
  JOURNAL   J Biol Chem 265 (9), 5008-5013 (1990)
   PUBMED   2318880
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK163933.1, AK080234.1 and AL513356.8.
            
            On Jun 9, 2003 this sequence version replaced NP_034815.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK163933.1, AK088804.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..415
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 22.67 cM"
     Protein         1..415
                     /product="lysosome-associated membrane glycoprotein 2
                     isoform 2 precursor"
                     /note="lysosome-associated membrane glycoprotein 2; CD107
                     antigen-like family member B; lysosomal membrane
                     glycoprotein type B; lysosomal membrane glycoprotein 2"
                     /calculated_mol_wt=43039
     sig_peptide     1..25
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=2634
     Region          225..363
                     /region_name="Lamp"
                     /note="Lysosome-associated membrane glycoprotein (Lamp);
                     pfam01299"
                     /db_xref="CDD:426189"
     Region          379..407
                     /region_name="TM_EGFR-like"
                     /note="Transmembrane domain of the Epidermal Growth Factor
                     Receptor family of Protein Tyrosine Kinases; cd12087"
                     /db_xref="CDD:213052"
     Site            order(380..381,384..385,387..389,391..392,395)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:213052"
     CDS             1..415
                     /gene="Lamp2"
                     /gene_synonym="CD107b; Lamp II; Lamp-2; Lamp-2a; Lamp-2b;
                     Lamp-2c; LGP-B; Mac3"
                     /coded_by="NM_010685.4:158..1405"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2"
                     /db_xref="CCDS:CCDS30093.1"
                     /db_xref="GeneID:16784"
                     /db_xref="MGI:MGI:96748"
ORIGIN      
        1 mclspvkgak liliflflga vqsnalivnl tdskgtclya ewemnftity ettnqtnkti
       61 tiavpdkath dgsscgddrn sakimiqfgf avswavnftk eashysihdi vlsyntsdst
      121 vfpgavakgv htvknpenfk vpldvifkcn svltynltpv vqkywgihlq afvqngtvsk
      181 neqvceedqt pttvapiiht tapsttttlt ptstptptpt ptptvgnysi rngnttclla
      241 tmglqlnite ekvpfifnin pattnftgsc qpqsaqlrln nsqikyldfi favknekrfy
      301 lkevnvymyl angsafnisn knlsfwdapl gssymcnkeq vlsvsrafqi ntfnlkvqpf
      361 nvtkgqysta qecsldddti lipiivgagl sgliivivia yligrrktya gyqtl
//
LOCUS       NP_112445                211 aa            linear   ROD 09-OCT-2023
DEFINITION  interleukin-6 isoform 1 precursor [Mus musculus].
ACCESSION   NP_112445
VERSION     NP_112445.1
DBSOURCE    REFSEQ: accession NM_031168.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 211)
  AUTHORS   Palmisano B, Riminucci M and Karsenty G.
  TITLE     Interleukin-6 signaling in osteoblasts regulates bone remodeling
            during exercise
  JOURNAL   Bone 176, 116870 (2023)
   PUBMED   37586472
  REMARK    GeneRIF: Interleukin-6 signaling in osteoblasts regulates bone
            remodeling during exercise.
REFERENCE   2  (residues 1 to 211)
  AUTHORS   Zhu Y, Wang L, Liu R, Ding X, Yin S, Chen Y, Zhu C, Wang Z and Li
            W.
  TITLE     Inhibition of PRMT1 alleviates sepsis-induced acute kidney injury
            in mice by blocking the TGF-beta1 and IL-6 trans-signaling pathways
  JOURNAL   FEBS Open Bio 13 (10), 1859-1873 (2023)
   PUBMED   37525933
  REMARK    GeneRIF: Inhibition of PRMT1 alleviates sepsis-induced acute kidney
            injury in mice by blocking the TGF-beta1 and IL-6 trans-signaling
            pathways.
REFERENCE   3  (residues 1 to 211)
  AUTHORS   Okamura K, Lu S, He Z, Altmann C, Montford JR, Li AS, Lucia MS,
            Orlicky DJ, Weiser-Evans M and Faubel S.
  TITLE     IL-6 mediates the hepatic acute phase response after prerenal
            azotemia in a clinically defined murine model
  JOURNAL   Am J Physiol Renal Physiol 325 (3), F328-F344 (2023)
   PUBMED   37471421
  REMARK    GeneRIF: IL-6 mediates the hepatic acute phase response after
            prerenal azotemia in a clinically defined murine model.
REFERENCE   4  (residues 1 to 211)
  AUTHORS   Millrine D, Cardus Figueras A, Uceda Fernandez J, Andrews R,
            Szomolay B, Cossins BC, Rice CM, Li J, Tyrrell VJ, McLeod L,
            Holmans P, O'Donnell VB, Taylor PR, Turner SJ, Jenkins BJ, Jones
            GW, Topley N, Williams NM and Jones SA.
  TITLE     Th1 Cells Alter the Inflammatory Signature of IL-6 by Channeling
            STAT Transcription Factors to Alu-like Retroelements
  JOURNAL   J Immunol 211 (2), 274-286 (2023)
   PUBMED   37272871
  REMARK    GeneRIF: Th1 Cells Alter the Inflammatory Signature of IL-6 by
            Channeling STAT Transcription Factors to Alu-like Retroelements.
REFERENCE   5  (residues 1 to 211)
  AUTHORS   Choi BR, Johnson KR, Maric D and McGavern DB.
  TITLE     Monocyte-derived IL-6 programs microglia to rebuild damaged brain
            vasculature
  JOURNAL   Nat Immunol 24 (7), 1110-1123 (2023)
   PUBMED   37248420
  REMARK    GeneRIF: Monocyte-derived IL-6 programs microglia to rebuild
            damaged brain vasculature.
REFERENCE   6  (residues 1 to 211)
  AUTHORS   Chin H, Mock B, Kim HL, Kim H and Kozak CA.
  TITLE     The gene for the dihydropyridine-sensitive calcium channel alpha 2
            subunit (CCHL2A) maps to the proximal region of mouse chromosome 5
  JOURNAL   Genomics 13 (4), 1325-1327 (1992)
   PUBMED   1324224
REFERENCE   7  (residues 1 to 211)
  AUTHORS   Okada S, Nakauchi H, Nagayoshi K, Nakamura M, Miura Y and Suda T.
  TITLE     Synergistic effect of IL-3 and IL-6 on highly enriched murine
            hemopoietic progenitors
  JOURNAL   Exp Hematol 20 (5), 546-551 (1992)
   PUBMED   1350248
REFERENCE   8  (residues 1 to 211)
  AUTHORS   Vandevoorde V, Haegeman G and Fiers W.
  TITLE     TNF-mediated IL6 gene expression and cytotoxicity are co-inducible
            in TNF-resistant L929 cells
  JOURNAL   FEBS Lett 302 (3), 235-238 (1992)
   PUBMED   1318227
REFERENCE   9  (residues 1 to 211)
  AUTHORS   Fiorillo MT, Toniatti C, Van Snick J and Ciliberto G.
  TITLE     Expression of the murine interleukin 6 receptor in hepatoma cells:
            the intracytoplasmic domain is not required for interleukin 6
            signal transduction
  JOURNAL   Eur J Immunol 22 (3), 799-804 (1992)
   PUBMED   1312474
REFERENCE   10 (residues 1 to 211)
  AUTHORS   Bodine DM, Orlic D, Birkett NC, Seidel NE and Zsebo KM.
  TITLE     Stem cell factor increases colony-forming unit-spleen number in
            vitro in synergy with interleukin-6, and in vivo in Sl/Sld mice as
            a single factor
  JOURNAL   Blood 79 (4), 913-919 (1992)
   PUBMED   1371079
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC112933.16 and AK150440.1.
            
            Summary: This gene encodes a member of the interleukin family of
            cytokines that have important functions in immune response,
            hematopoiesis, inflammation and the acute phase response. The
            ectopic overexpression of the encoded protein in mice results in
            excessive plasma cells in circulation, leading to death. Mice
            lacking the encoded protein exhibit abnormalities in hepatic acute
            phase response, some immune mechanisms, bone resorption in response
            to estrogen, liver regeneration and wound healing. Alternative
            splicing results in multiple transcript variants encoding different
            isoforms. [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK150440.1, J03783.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..211
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 15.7 cM"
     Protein         1..211
                     /product="interleukin-6 isoform 1 precursor"
                     /note="interleukin HP-1; B-cell hybridoma growth factor"
                     /calculated_mol_wt=21735
     sig_peptide     1..24
                     /note="/evidence=ECO:0000269|PubMed:2948184,
                     ECO:0000269|PubMed:3262059; propagated from
                     UniProtKB/Swiss-Prot (P08505.1)"
                     /calculated_mol_wt=2667
     mat_peptide     25..211
                     /product="Interleukin-6. /id=PRO_0000015588"
                     /note="propagated from UniProtKB/Swiss-Prot (P08505.1)"
                     /calculated_mol_wt=21735
     Region          27..210
                     /region_name="IL6"
                     /note="Interleukin-6/G-CSF/MGF family; pfam00489"
                     /db_xref="CDD:395393"
     CDS             1..211
                     /gene="Il6"
                     /gene_synonym="Il-6"
                     /coded_by="NM_031168.2:79..714"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS19153.1"
                     /db_xref="GeneID:16193"
                     /db_xref="MGI:MGI:96559"
ORIGIN      
        1 mkflsardfh pvaflglmlv tttafptsqv rrgdftedtt pnrpvyttsq vgglithvlw
       61 eivemrkelc ngnsdcmnnd dalaennlkl peiqrndgcy qtgynqeicl lkissglley
      121 hsyleymknn lkdnkkdkar vlqrdtetli hifnqevkdl hkivlptpis nalltdkles
      181 qkewlrtkti qfilksleef lkvtlrstrq t
//
LOCUS       NP_001397181             419 aa            linear   ROD 09-OCT-2023
DEFINITION  Friend leukemia integration 1 transcription factor isoform 3 [Mus
            musculus].
ACCESSION   NP_001397181 XP_006510071
VERSION     NP_001397181.1
DBSOURCE    REFSEQ: accession NM_001410252.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 419)
  AUTHORS   Wang X, Richard ML, Caldwell TS, Sundararaj K, Sato S, Nowling TK
            and Zhang XK.
  TITLE     Role of the transcription factor Fli-1 on the CXCL10/CXCR3 Axis
  JOURNAL   Front Immunol 14, 1219279 (2023)
   PUBMED   37790939
  REMARK    GeneRIF: Role of the transcription factor Fli-1 on the CXCL10/CXCR3
            Axis.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 419)
  AUTHORS   Sato S, Zhang XK, Matsuoka N, Sumichika Y, Saito K, Yoshida S,
            Matsumoto H, Temmoku J, Fujita Y, Asano T and Migita K.
  TITLE     Transcription factor Fli-1 impacts the expression of CXCL13 and
            regulates immune cell infiltration into the kidney in MRL/lpr mouse
  JOURNAL   Lupus Sci Med 10 (1) (2023)
   PUBMED   37094946
  REMARK    GeneRIF: Transcription factor Fli-1 impacts the expression of
            CXCL13 and regulates immune cell infiltration into the kidney in
            MRL/lpr mouse.
REFERENCE   3  (residues 1 to 419)
  AUTHORS   Shintani A, Fukai S, Nobusawa R, Taniguchi K, Hatatani T, Nagai H,
            Sakai T, Yoshimura T, Miyasaka M and Hayasaka H.
  TITLE     Dach1 transcription factor regulates the expression of peripheral
            node addressin and lymphocyte trafficking in lymph nodes
  JOURNAL   Curr Res Immunol 3, 175-185 (2022)
   PUBMED   36045707
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 419)
  AUTHORS   Sinha T, Lammerts van Bueren K, Dickel DE, Zlatanova I, Thomas R,
            Lizama CO, Xu SM, Zovein AC, Ikegami K, Moskowitz IP, Pollard KS,
            Pennacchio LA and Black BL.
  TITLE     Differential Etv2 threshold requirement for endothelial and
            erythropoietic development
  JOURNAL   Cell Rep 39 (9), 110881 (2022)
   PUBMED   35649376
REFERENCE   5  (residues 1 to 419)
  AUTHORS   Sarrazin S, Starck J, Gonnet C, Doubeikovski A, Melet F and Morle
            F.
  TITLE     Negative and translation termination-dependent positive control of
            FLI-1 protein synthesis by conserved overlapping 5' upstream open
            reading frames in Fli-1 mRNA
  JOURNAL   Mol Cell Biol 20 (9), 2959-2969 (2000)
   PUBMED   10757781
REFERENCE   6  (residues 1 to 419)
  AUTHORS   Barbeau B, Bergeron D, Beaulieu M, Nadjem Z and Rassart E.
  TITLE     Characterization of the human and mouse Fli-1 promoter regions
  JOURNAL   Biochim Biophys Acta 1307 (2), 220-232 (1996)
   PUBMED   8679708
REFERENCE   7  (residues 1 to 419)
  AUTHORS   Watson DK, Smyth FE, Thompson DM, Cheng JQ, Testa JR, Papas TS and
            Seth A.
  TITLE     The ERGB/Fli-1 gene: isolation and characterization of a new member
            of the family of human ETS transcription factors
  JOURNAL   Cell Growth Differ 3 (10), 705-713 (1992)
   PUBMED   1445800
REFERENCE   8  (residues 1 to 419)
  AUTHORS   Delattre O, Zucman J, Plougastel B, Desmaze C, Melot T, Peter M,
            Kovar H, Joubert I, de Jong P, Rouleau G et al.
  TITLE     Gene fusion with an ETS DNA-binding domain caused by chromosome
            translocation in human tumours
  JOURNAL   Nature 359 (6391), 162-165 (1992)
   PUBMED   1522903
REFERENCE   9  (residues 1 to 419)
  AUTHORS   Moore SK, Appella E, Villar CJ and Kozak CA.
  TITLE     Mapping of the mouse 86-kDa heat-shock protein expressed gene
            (Hsp86-1) on chromosome 12 and related genes on chromosomes 3, 4,
            9, and 11
  JOURNAL   Genomics 10 (4), 1019-1029 (1991)
   PUBMED   1916807
REFERENCE   10 (residues 1 to 419)
  AUTHORS   Bergeron D, Poliquin L, Kozak CA and Rassart E.
  TITLE     Identification of a common viral integration region in Cas-Br-E
            murine leukemia virus-induced non-T-, non-B-cell lymphomas
  JOURNAL   J Virol 65 (1), 7-15 (1991)
   PUBMED   1845910
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127581.4 and AC141646.4.
            
            On Aug 1, 2022 this sequence version replaced XP_006510071.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422603.217109.1,
                                           SRR17784646.1104630.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..419
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 17.74 cM"
     Protein         1..419
                     /product="Friend leukemia integration 1 transcription
                     factor isoform 3"
                     /note="friend leukemia integration 1 transcription factor;
                     retroviral integration site protein Fli-1"
                     /calculated_mol_wt=47465
     Region          81..171
                     /region_name="SAM_PNT-FLI-1"
                     /note="Sterile alpha motif (SAM)/Pointed domain of friend
                     leukemia integration 1 transcription activator; cd08541"
                     /db_xref="CDD:188883"
     Region          247..330
                     /region_name="ETS"
                     /note="erythroblast transformation specific domain;
                     smart00413"
                     /db_xref="CDD:197710"
     CDS             1..419
                     /gene="Fli1"
                     /gene_synonym="EWSR2; Fli-1; SIC-1; Sic1"
                     /coded_by="NM_001410252.1:385..1644"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="GeneID:14247"
                     /db_xref="MGI:MGI:95554"
ORIGIN      
        1 mtasgspdyg qphkinplpp qqewinqpvr vnvkreydhm ngsrespvdc svskcnklvg
       61 ggeanpmnyn symdekngpp ppnmttnerr vivpadptlw tqehvrqwle waikeyglme
      121 idtsffqnmd gkelckmnke dflratsayn tevllshlsy lressllayn ttshtdqssr
      181 lnvkedpsyd svrrgawnnn mnsglnkspl lggsqtmgkn teqrpqpdpy qilgptssrl
      241 anpgsgqiql wqfllellsd sanascitwe gtngefkmtd pdevarrwge rkskpnmnyd
      301 klsralryyy dknimtkvhg kryaykfdfh giaqalqphp tetsmykyps disympsyha
      361 hqqkvnfvps hpssmpvtss sffgaasqyw tsptagiypn psvprhpnth vpshlgsyy
//
LOCUS       NP_035196               1257 aa            linear   ROD 09-OCT-2023
DEFINITION  period circadian protein homolog 2 isoform 1 [Mus musculus].
ACCESSION   NP_035196
VERSION     NP_035196.2
DBSOURCE    REFSEQ: accession NM_011066.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1257)
  AUTHORS   Millius A, Yamada RG, Fujishima H, Maeda K, Standley DM, Sumiyama
            K, Perrin D and Ueda HR.
  TITLE     Circadian ribosome profiling reveals a role for the Period2
            upstream open reading frame in sleep
  JOURNAL   Proc Natl Acad Sci U S A 120 (40), e2214636120 (2023)
   PUBMED   37769257
  REMARK    GeneRIF: Circadian ribosome profiling reveals a role for the
            Period2 upstream open reading frame in sleep.
REFERENCE   2  (residues 1 to 1257)
  AUTHORS   Sayson LV, Lee HJ, Ortiz DM, Kim M, Custodio RJP, Lee CH, Lee YS,
            Cheong JH and Kim HJ.
  TITLE     The differential vulnerabilities of Per2 knockout mice to the
            addictive properties of methamphetamine and cocaine
  JOURNAL   Prog Neuropsychopharmacol Biol Psychiatry 126, 110782 (2023)
   PUBMED   37141987
  REMARK    GeneRIF: The differential vulnerabilities of Per2 knockout mice to
            the addictive properties of methamphetamine and cocaine.
REFERENCE   3  (residues 1 to 1257)
  AUTHORS   Bora G, Onel T, Yildirim E and Yaba A.
  TITLE     Circadian regulation of mTORC1 signaling via Per2 dependent
            mechanism disrupts folliculogenesis and oocyte maturation in female
            mice
  JOURNAL   J Mol Histol 54 (3), 217-229 (2023)
   PUBMED   37162693
  REMARK    GeneRIF: Circadian regulation of mTORC1 signaling via Per2
            dependent mechanism disrupts folliculogenesis and oocyte maturation
            in female mice.
REFERENCE   4  (residues 1 to 1257)
  AUTHORS   Guo L, Cen H, Weng J, He Y, Guo X, He D, Liu K, Duan S, Yang J,
            Zhang X, Qin Z, Wan Y, Chen Z and Wu B.
  TITLE     PER2 integrates circadian disruption and pituitary tumorigenesis
  JOURNAL   Theranostics 13 (8), 2657-2672 (2023)
   PUBMED   37215573
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1257)
  AUTHORS   Wendrich KS, Azimi H, Ripperger JA, Ravussin Y, Rainer G and
            Albrecht U.
  TITLE     Deletion of the Circadian Clock Gene Per2 in the Whole Body, but
            Not in Neurons or Astroglia, Affects Sleep in Response to Sleep
            Deprivation
  JOURNAL   Clocks Sleep 5 (2), 204-225 (2023)
   PUBMED   37092429
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1257)
  AUTHORS   Takumi T, Taguchi K, Miyake S, Sakakida Y, Takashima N, Matsubara
            C, Maebayashi Y, Okumura K, Takekida S, Yamamoto S, Yagita K, Yan
            L, Young MW and Okamura H.
  TITLE     A light-independent oscillatory gene mPer3 in mouse SCN and OVLT
  JOURNAL   EMBO J 17 (16), 4753-4759 (1998)
   PUBMED   9707434
REFERENCE   7  (residues 1 to 1257)
  AUTHORS   Sassone-Corsi,P.
  TITLE     Molecular clocks: mastering time by gene regulation
  JOURNAL   Nature 392 (6679), 871-874 (1998)
   PUBMED   9582067
REFERENCE   8  (residues 1 to 1257)
  AUTHORS   Takumi T, Matsubara C, Shigeyoshi Y, Taguchi K, Yagita K,
            Maebayashi Y, Sakakida Y, Okumura K, Takashima N and Okamura H.
  TITLE     A new mammalian period gene predominantly expressed in the
            suprachiasmatic nucleus
  JOURNAL   Genes Cells 3 (3), 167-176 (1998)
   PUBMED   9619629
REFERENCE   9  (residues 1 to 1257)
  AUTHORS   Albrecht U, Sun ZS, Eichele G and Lee CC.
  TITLE     A differential response of two putative mammalian circadian
            regulators, mper1 and mper2, to light
  JOURNAL   Cell 91 (7), 1055-1064 (1997)
   PUBMED   9428527
REFERENCE   10 (residues 1 to 1257)
  AUTHORS   Shearman LP, Zylka MJ, Weaver DR, Kolakowski LF Jr and Reppert SM.
  TITLE     Two period homologs: circadian expression and photic regulation in
            the suprachiasmatic nuclei
  JOURNAL   Neuron 19 (6), 1261-1269 (1997)
   PUBMED   9427249
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC109199.10 and AC110510.6.
            
            On Jul 25, 2007 this sequence version replaced NP_035196.1.
            
            Summary: This gene is a member of the Period family of genes and is
            expressed in a circadian pattern in the suprachiasmatic nucleus,
            the primary circadian pacemaker in the mammalian brain. Genes in
            this family encode components of the circadian rhythms of locomotor
            activity, metabolism, and behavior. This gene is upregulated by
            Clock/Arntl heterodimers but then represses this upregulation in a
            feedback loop using Per/Cry heterodimers to interact with
            Clock/Arntl. Polymorphisms in this gene may increase the risk of
            getting certain cancers and have been linked to sleep disorders.
            [provided by RefSeq, Jan 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF036893.1, AK122253.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1257
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 46.13 cM"
     Protein         1..1257
                     /product="period circadian protein homolog 2 isoform 1"
                     /note="period 2; period circadian protein homolog 2;
                     circadian clock protein PERIOD 2; period homolog 2"
                     /calculated_mol_wt=135769
     Region          1..60
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O54943.3)"
     Region          109..118
                     /region_name="Nuclear export signal 1.
                     /evidence=ECO:0000269|PubMed:11889036"
                     /note="propagated from UniProtKB/Swiss-Prot (O54943.3)"
     Region          306..310
                     /region_name="LXXLL"
                     /note="propagated from UniProtKB/Swiss-Prot (O54943.3)"
     Region          344..428
                     /region_name="PAS_3"
                     /note="PAS fold; pfam08447"
                     /db_xref="CDD:430001"
     Site            order(344,348,354,367..370,398,403)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:238075"
     Site            order(364,368,376,379..380,410,412)
                     /site_type="other"
                     /note="heme pocket [chemical binding]"
                     /db_xref="CDD:238075"
     Region          <445..>982
                     /region_name="PRK10263"
                     /note="DNA translocase FtsK; Provisional"
                     /db_xref="CDD:236669"
     Region          460..469
                     /region_name="Nuclear export signal 2.
                     /evidence=ECO:0000269|PubMed:11889036"
                     /note="propagated from UniProtKB/Swiss-Prot (O54943.3)"
     Region          471..565
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O54943.3)"
     Region          478..482
                     /region_name="Important for protein stability.
                     /evidence=ECO:0000250|UniProtKB:Q9Z301"
                     /note="propagated from UniProtKB/Swiss-Prot (O54943.3)"
     Region          510..709
                     /region_name="CSNK1E binding domain.
                     /evidence=ECO:0000269|PubMed:14701732"
                     /note="propagated from UniProtKB/Swiss-Prot (O54943.3)"
     Site            525
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:16097765; propagated from
                     UniProtKB/Swiss-Prot (O54943.3)"
     Site            528
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:16097765; propagated from
                     UniProtKB/Swiss-Prot (O54943.3)"
     Site            531
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:16097765; propagated from
                     UniProtKB/Swiss-Prot (O54943.3)"
     Site            538
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:16097765; propagated from
                     UniProtKB/Swiss-Prot (O54943.3)"
     Site            544
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:16097765; propagated from
                     UniProtKB/Swiss-Prot (O54943.3)"
     Site            554
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000269|PubMed:16097765; propagated from
                     UniProtKB/Swiss-Prot (O54943.3)"
     Region          617..638
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O54943.3)"
     Site            659
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O15055; propagated from
                     UniProtKB/Swiss-Prot (O54943.3)"
     Site            693
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (O54943.3)"
     Site            697
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (O54943.3)"
     Site            706
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:16097765; propagated from
                     UniProtKB/Swiss-Prot (O54943.3)"
     Region          757..832
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O54943.3)"
     Site            758
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:16097765; propagated from
                     UniProtKB/Swiss-Prot (O54943.3)"
     Site            763
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:16097765; propagated from
                     UniProtKB/Swiss-Prot (O54943.3)"
     Region          778..794
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000269|PubMed:11889036"
                     /note="propagated from UniProtKB/Swiss-Prot (O54943.3)"
     Region          <790..1038
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Site            858
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000269|PubMed:16097765; propagated from
                     UniProtKB/Swiss-Prot (O54943.3)"
     Region          882..1067
                     /region_name="Interaction with PPARG.
                     /evidence=ECO:0000269|PubMed:21035761"
                     /note="propagated from UniProtKB/Swiss-Prot (O54943.3)"
     Site            939
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:16097765; propagated from
                     UniProtKB/Swiss-Prot (O54943.3)"
     Site            964
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000269|PubMed:16097765; propagated from
                     UniProtKB/Swiss-Prot (O54943.3)"
     Site            971
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:16097765; propagated from
                     UniProtKB/Swiss-Prot (O54943.3)"
     Region          983..990
                     /region_name="Nuclear export signal 3.
                     /evidence=ECO:0000269|PubMed:11889036"
                     /note="propagated from UniProtKB/Swiss-Prot (O54943.3)"
     Region          994..1044
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O54943.3)"
     Region          1040..1210
                     /region_name="Period_C"
                     /note="Period protein 2/3C-terminal region; pfam12114"
                     /db_xref="CDD:432341"
     Region          1051..1055
                     /region_name="LXXLL"
                     /note="propagated from UniProtKB/Swiss-Prot (O54943.3)"
     Region          1070..1115
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O54943.3)"
     Site            1126
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:16097765; propagated from
                     UniProtKB/Swiss-Prot (O54943.3)"
     Region          1157..1257
                     /region_name="CRY binding domain.
                     /evidence=ECO:0000250|UniProtKB:Q9Z301"
                     /note="propagated from UniProtKB/Swiss-Prot (O54943.3)"
     Region          1224..1257
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O54943.3)"
     CDS             1..1257
                     /gene="Per2"
                     /gene_synonym="mKIAA0347; mPer2"
                     /coded_by="NM_011066.4:153..3926"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS35663.1"
                     /db_xref="GeneID:18627"
                     /db_xref="MGI:MGI:1195265"
ORIGIN      
        1 mngyvdfsps ptsptkepga pqptqavlqe dvdmssgssg nencstgrds qgsdcddngk
       61 elrmlvessn thpspddafr lmmteaehnp stsgcsseqs akadahkeli rtlkelkvhl
      121 padkkakgka stlatlkyal rsvkqvkane eyyqllmsse sqpcsvdvps ysmeqvegit
      181 seyivknadm favavslvsg kilyisnqva sifhckkdaf sdakfvefla phdvsvfhsy
      241 ttpyklppws vcsgldsftq ecmeeksffc rvsvgkhhen eiryqpfrmt pylvkvqeqq
      301 gaesqlccll laervhsgye aprippekri fttthtpncl fqavderavp llgylpqdli
      361 etpvlvqlhp sdrplmlaih kkilqaggqp fdyspirfrt rngeyitldt swssfinpws
      421 rkisfiigrh kvrvgplned vfaaspcpee ktphpsvqel teqihrllmq pvphsgssgy
      481 gslgsngshe hlmsqtsssd sngqeeshrr rsgifktsgk iqtkshvshe sggqkeasva
      541 emqssppaqv kavttierds sgaslpkasf peelayknqp pcsyqqiscl dsvirylesc
      601 seaatlkrkc efpanipsrk atvspglhsg eaarpskvts htevsahlss ltlpgkaesv
      661 vsltsqcsys stivhvgdkk pqpeletved masgpesldg aagglsqekg plqklgltke
      721 vlaahtqree qgflqrfrev srlsalqahc qnylqersra qasdrglrnt sglesswkkt
      781 gknrklkskr vktrdssest gsggpvshrp plmglnataw spsdtsqssc psapfptavp
      841 ayplpvfqap givstpgtvv appaathtgf tmpvvpmgtq pefavqplpf aaplapvmaf
      901 mlpsypfppa tpnlpqaflp sqphfpahpt laseitpasq aefpsrtstl rqpcacpvtp
      961 pagtvalgra spplfqsrgs splqlnllql eeapegstga agtlgttgta asgldctsgt
     1021 srdrqpkapp tcnepsdtqn sdaistssdl lnlllgedlc satgsalsrs gasatsdslg
     1081 ssslgfgtsq sgagssdtsh tskyfgsids sennhkakmi pdteeseqfi kyvlqdpiwl
     1141 lmantddsim mtyqlpsrdl qavlkedqek lkllqrsqpr ftegqrrelr evhpwvhtgg
     1201 lptaidvtgc vyceseekgn iclpyeedsp spglcdtsea keeegeqltg prieaqt
//
LOCUS       NP_001368855             657 aa            linear   ROD 09-OCT-2023
DEFINITION  broad substrate specificity ATP-binding cassette transporter ABCG2
            [Mus musculus].
ACCESSION   NP_001368855 XP_030111262
VERSION     NP_001368855.1
DBSOURCE    REFSEQ: accession NM_001381926.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 657)
  AUTHORS   Notsu T, Kurata Y, Ninomiya H, Taufiq F, Komatsu K, Miake J, Sawano
            T, Tsuneto M, Shirayoshi Y and Hisatome I.
  TITLE     Inhibition of the uric acid efflux transporter ABCG2 enhances
            stimulating effect of soluble uric acid on IL-1beta production in
            murine macrophage-like J774.1 cells
  JOURNAL   Hypertens Res 46 (10), 2368-2377 (2023)
   PUBMED   37592041
  REMARK    GeneRIF: Inhibition of the uric acid efflux transporter ABCG2
            enhances stimulating effect of soluble uric acid on IL-1beta
            production in murine macrophage-like J774.1 cells.
REFERENCE   2  (residues 1 to 657)
  AUTHORS   Harby SA, Khalil NA, El-Sayed NS, Thabet EH, Saleh SR and Fathelbab
            MH.
  TITLE     Implications of BCRP modulation on PTZ-induced seizures in mice:
            Role of ko143 and metformin as adjuvants to lamotrigine
  JOURNAL   Naunyn Schmiedebergs Arch Pharmacol 396 (10), 2627-2636 (2023)
   PUBMED   37067582
  REMARK    GeneRIF: Implications of BCRP modulation on PTZ-induced seizures in
            mice: Role of ko143 and metformin as adjuvants to lamotrigine.
REFERENCE   3  (residues 1 to 657)
  AUTHORS   Blanco-Paniagua E, Alvarez-Fernandez L, Rodriguez-Alonso A,
            Millan-Garcia A, Alvarez AI and Merino G.
  TITLE     Role of the Abcg2 Transporter in Secretion into Milk of the
            Anthelmintic Clorsulon: Interaction with Ivermectin
  JOURNAL   Antimicrob Agents Chemother 67 (5), e0009523 (2023)
   PUBMED   37078871
  REMARK    GeneRIF: Role of the Abcg2 Transporter in Secretion into Milk of
            the Anthelmintic Clorsulon: Interaction with Ivermectin.
REFERENCE   4  (residues 1 to 657)
  AUTHORS   Wu C, Xiao Y, Wu C, Xie D, Luo M, Yao D, Chen M and Lu D.
  TITLE     Regulation of BCRP expression and sulfasalazine pharmacokinetics by
            the nuclear receptor REV-ERBalpha
  JOURNAL   Xenobiotica 53 (3), 215-222 (2023)
   PUBMED   37039301
  REMARK    GeneRIF: Regulation of BCRP expression and sulfasalazine
            pharmacokinetics by the nuclear receptor REV-ERBalpha.
REFERENCE   5  (residues 1 to 657)
  AUTHORS   Alvarez-Fernandez L, Gomez-Gomez A, Haro N, Garcia-Lino AM, Alvarez
            AI, Pozo OJ and Merino G.
  TITLE     ABCG2 transporter plays a key role in the biodistribution of
            melatonin and its main metabolites
  JOURNAL   J Pineal Res 74 (2), e12849 (2023)
   PUBMED   36562106
  REMARK    GeneRIF: ABCG2 transporter plays a key role in the biodistribution
            of melatonin and its main metabolites.
REFERENCE   6  (residues 1 to 657)
  AUTHORS   Geschwind DH, Ou J, Easterday MC, Dougherty JD, Jackson RL, Chen Z,
            Antoine H, Terskikh A, Weissman IL, Nelson SF and Kornblum HI.
  TITLE     A genetic analysis of neural progenitor differentiation
  JOURNAL   Neuron 29 (2), 325-339 (2001)
   PUBMED   11239426
REFERENCE   7  (residues 1 to 657)
  AUTHORS   Jonker JW, Smit JW, Brinkhuis RF, Maliepaard M, Beijnen JH,
            Schellens JH and Schinkel AH.
  TITLE     Role of breast cancer resistance protein in the bioavailability and
            fetal penetration of topotecan
  JOURNAL   J Natl Cancer Inst 92 (20), 1651-1656 (2000)
   PUBMED   11036110
REFERENCE   8  (residues 1 to 657)
  AUTHORS   Schriml LM and Dean M.
  TITLE     Identification of 18 mouse ABC genes and characterization of the
            ABC superfamily in Mus musculus
  JOURNAL   Genomics 64 (1), 24-31 (2000)
   PUBMED   10708515
REFERENCE   9  (residues 1 to 657)
  AUTHORS   Allen JD, Brinkhuis RF, Wijnholds J and Schinkel AH.
  TITLE     The mouse Bcrp1/Mxr/Abcp gene: amplification and overexpression in
            cell lines selected for resistance to topotecan, mitoxantrone, or
            doxorubicin
  JOURNAL   Cancer Res 59 (17), 4237-4241 (1999)
   PUBMED   10485464
REFERENCE   10 (residues 1 to 657)
  AUTHORS   Allikmets R, Schriml LM, Hutchinson A, Romano-Spica V and Dean M.
  TITLE     A human placenta-specific ATP-binding cassette gene (ABCP) on
            chromosome 4q22 that is involved in multidrug resistance
  JOURNAL   Cancer Res 58 (23), 5337-5339 (1998)
   PUBMED   9850061
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121855.3 and AC121859.2.
            
            On Apr 20, 2020 this sequence version replaced XP_030111262.1.
            
            Summary: The membrane-associated protein encoded by this gene is
            included in the superfamily of ATP-binding cassette (ABC)
            transporters. ABC proteins transport various molecules across
            extra- and intra-cellular membranes. ABC genes are divided into
            seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,
            White). This protein is a member of the White subfamily.
            Alternatively referred to as a breast cancer resistance protein,
            the human protein functions as a xenobiotic transporter which may
            play a major role in multi-drug resistance. This protein likely
            serves as a cellular defense mechanism in response to mitoxantrone
            and anthracycline exposure. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.1928304.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..657
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 27.82 cM"
     Protein         1..657
                     /product="broad substrate specificity ATP-binding cassette
                     transporter ABCG2"
                     /EC_number="7.6.2.2"
                     /note="mitoxantrone resistance protein 1; ATP-binding
                     cassette sub-family G member 2; breast cancer resistance
                     protein 1 homolog; urate exporter; ATP-binding cassette,
                     sub-family G (WHITE), member 2"
                     /calculated_mol_wt=72891
     Region          1..24
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TMS5.1)"
     Region          46..651
                     /region_name="3a01204"
                     /note="The Eye Pigment Precursor Transporter (EPP) Family
                     protein; TIGR00955"
                     /db_xref="CDD:273361"
     Site            394..414
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TMS5.1)"
     Site            429..449
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TMS5.1)"
     Site            478..498
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TMS5.1)"
     Site            507..527
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TMS5.1)"
     Site            536..556
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TMS5.1)"
     Site            596
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TMS5.1)"
     Site            600
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TMS5.1)"
     Site            633..653
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TMS5.1)"
     CDS             1..657
                     /gene="Abcg2"
                     /gene_synonym="ABC15; ABCP; BCRP; Bcrp1; MXR; MXR1"
                     /coded_by="NM_001381926.1:178..2151"
                     /db_xref="GeneID:26357"
                     /db_xref="MGI:MGI:1347061"
ORIGIN      
        1 msssndhvlv pmsqrnnngl prmnsravrt laegdvlsfh hityrvkvks gflvrktvek
       61 eilsdingim kpglnailgp tgggksslld vlaarkdpkg lsgdvlinga pqpahfkccs
      121 gyvvqddvvm gtltvrenlq fsaalrlptt mknhekneri ntiikelgle kvadskvgtq
      181 firgisgger krtsigmeli tdpsilflde pttgldssta navllllkrm skqgrtiifs
      241 ihqprysifk lfdsltllas gklvfhgpaq kaleyfasag yhcepynnpa dffldvingd
      301 ssavmlnree qdneanktee pskgekpvie nlsefyinsa iygetkaeld qlpgaqekkg
      361 tsafkepvyv tsfchqlrwi arrsfknllg npqasvaqli vtvilgliig aiyfdlkyda
      421 agmqnragvl fflttnqcfs svsavelfvv ekklfiheyi sgyyrvssyf fgkvmsdllp
      481 mrflpsvift cilyfmlglk ktvdaffimm ftlimvayta ssmalaiatg qsvvsvatll
      541 mtiafvfmml fsgllvnlrt igpwlswlqy fsiprygfta lqyneflgqe fcpgfnvtdn
      601 stcvnsyaic tgneylinqg ielspwglwk nhvalacmii ifltiaylkl lflkkys
//
LOCUS       NP_001346489              81 aa            linear   ROD 09-OCT-2023
DEFINITION  costars family protein ABRACL [Mus musculus].
ACCESSION   NP_001346489 XP_011241512
VERSION     NP_001346489.1
DBSOURCE    REFSEQ: accession NM_001359560.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 81)
  AUTHORS   Troumpoukis D, Vasileiou AR, Siskos N, Stylianopoulou E, Ypsilantis
            P, Skavdis G and Grigoriou ME.
  TITLE     Characterization of the Abracl-Expressing Cell Populations in the
            Embryonic Mammalian Telencephalon
  JOURNAL   Biomolecules 13 (9), 1337 (2023)
   PUBMED   37759737
  REMARK    GeneRIF: Characterization of the Abracl-Expressing Cell Populations
            in the Embryonic Mammalian Telencephalon.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 81)
  AUTHORS   Pensold D, Symmank J, Hahn A, Lingner T, Salinas-Riester G, Downie
            BR, Ludewig F, Rotzsch A, Haag N, Andreas N, Schubert K, Hubner CA,
            Pieler T and Zimmer G.
  TITLE     The DNA Methyltransferase 1 (DNMT1) Controls the Shape and Dynamics
            of Migrating POA-Derived Interneurons Fated for the Murine Cerebral
            Cortex
  JOURNAL   Cereb Cortex 27 (12), 5696-5714 (2017)
   PUBMED   29117290
REFERENCE   3  (residues 1 to 81)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   4  (residues 1 to 81)
  AUTHORS   Nelson PS, Pritchard C, Abbott D and Clegg N.
  TITLE     The human (PEDB) and mouse (mPEDB) Prostate Expression Databases
  JOURNAL   Nucleic Acids Res 30 (1), 218-220 (2002)
   PUBMED   11752298
REFERENCE   5  (residues 1 to 81)
  AUTHORS   Kagami Y and Furuichi T.
  TITLE     Investigation of differentially expressed genes during the
            development of mouse cerebellum
  JOURNAL   Brain Res Gene Expr Patterns 1 (1), 39-59 (2001)
   PUBMED   15018818
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB838485.1, AC153896.10, AK013984.1 and AW492391.1.
            
            On Jan 13, 2018 this sequence version replaced XP_011241512.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AW823811.1, SRR7345562.101482.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..81
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 7.39 cM"
     Protein         1..81
                     /product="costars family protein ABRACL"
                     /note="ABRA C-terminal-like protein"
                     /calculated_mol_wt=8927
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:Q9P1F3; propagated from
                     UniProtKB/Swiss-Prot (Q4KML4.1)"
     Region          2..79
                     /region_name="Costars"
                     /note="pfam14705"
                     /db_xref="CDD:434145"
     CDS             1..81
                     /gene="Abracl"
                     /gene_synonym="1700028I04Rik; 3110003A17Rik"
                     /coded_by="NM_001359560.1:103..348"
                     /db_xref="CCDS:CCDS48506.1"
                     /db_xref="GeneID:73112"
                     /db_xref="MGI:MGI:1920362"
ORIGIN      
        1 mnvehevnll veeihrlgsr nadgklsvkf gvlfqddrca nlfealvgtl kaakrrkivt
       61 yagelllqgv hddvdivllq d
//
LOCUS       NP_035616                722 aa            linear   ROD 09-OCT-2023
DEFINITION  signal transducer and activator of transcription 3 isoform 3 [Mus
            musculus].
ACCESSION   NP_035616 XP_912491
VERSION     NP_035616.1
DBSOURCE    REFSEQ: accession NM_011486.5
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 722)
  AUTHORS   Xiao D, Zeng T, Zhu W, Yu ZZ, Huang W, Yi H, Lu SS, Feng J, Feng
            XP, Wu D, Wen Q, Zhou JH, Yuan L, Zhuang W and Xiao ZQ.
  TITLE     ANXA1 Promotes Tumor Immune Evasion by Binding PARP1 and
            Upregulating Stat3-Induced Expression of PD-L1 in Multiple Cancers
  JOURNAL   Cancer Immunol Res 11 (10), 1367-1383 (2023)
   PUBMED   37566399
  REMARK    GeneRIF: ANXA1 Promotes Tumor Immune Evasion by Binding PARP1 and
            Upregulating Stat3-Induced Expression of PD-L1 in Multiple Cancers.
REFERENCE   2  (residues 1 to 722)
  AUTHORS   Ramos RB, Martino N, Chuy D, Lu S, Zuo MXG, Balasubramanian U, Di
            John Portela I, Vincent PA and Adam AP.
  TITLE     Shock drives a STAT3 and JunB-mediated coordinated transcriptional
            and DNA methylation response in the endothelium
  JOURNAL   J Cell Sci 136 (18) (2023)
   PUBMED   37667913
  REMARK    GeneRIF: Shock drives a STAT3 and JunB-mediated coordinated
            transcriptional and DNA methylation response in the endothelium.
REFERENCE   3  (residues 1 to 722)
  AUTHORS   Liu L, Xu W, Li K, Hu Y, Shen L, Zhang H and Wang Y.
  TITLE     Kv1.3 mediates ox-LDL-induced vascular smooth muscle cell
            proliferation through JAK2/STAT3 signaling pathway
  JOURNAL   Arch Biochem Biophys 746, 109719 (2023)
   PUBMED   37591369
  REMARK    GeneRIF: Kv1.3 mediates ox-LDL-induced vascular smooth muscle cell
            proliferation through JAK2/STAT3 signaling pathway.
REFERENCE   4  (residues 1 to 722)
  AUTHORS   Xu F, Lu S, Jia X and Zhou Y.
  TITLE     Bromodomain protein 4 mediates the roles of TGFbeta1-induced Stat3
            signaling in mouse liver fibrogenesis
  JOURNAL   Toxicol Lett 385, 42-50 (2023)
   PUBMED   37634812
  REMARK    GeneRIF: Bromodomain protein 4 mediates the roles of
            TGFbeta1-induced Stat3 signaling in mouse liver fibrogenesis.
REFERENCE   5  (residues 1 to 722)
  AUTHORS   Pencik J, Philippe C, Schlederer M, Atas E, Pecoraro M,
            Grund-Groschke S, Li WJ, Tracz A, Heidegger I, Lagger S, Trachtova
            K, Oberhuber M, Heitzer E, Aksoy O, Neubauer HA, Wingelhofer B,
            Orlova A, Witzeneder N, Dillinger T, Redl E, Greiner G, D'Andrea D,
            Ostman JR, Tangermann S, Hermanova I, Schafer G, Sternberg F, Pohl
            EE, Sternberg C, Varady A, Horvath J, Stoiber D, Malcolm TI, Turner
            SD, Parkes EE, Hantusch B, Egger G, Rose-John S, Poli V, Jain S,
            Armstrong CWD, Hoermann G, Goffin V, Aberger F, Moriggl R,
            Carracedo A, McKinney C, Kennedy RD, Klocker H, Speicher MR, Tang
            DG, Moazzami AA, Heery DM, Hacker M and Kenner L.
  TITLE     STAT3/LKB1 controls metastatic prostate cancer by regulating
            mTORC1/CREB pathway
  JOURNAL   Mol Cancer 22 (1), 133 (2023)
   PUBMED   37573301
  REMARK    GeneRIF: STAT3/LKB1 controls metastatic prostate cancer by
            regulating mTORC1/CREB pathway.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 722)
  AUTHORS   Schaefer TS, Sanders LK and Nathans D.
  TITLE     Cooperative transcriptional activity of Jun and Stat3 beta, a short
            form of Stat3
  JOURNAL   Proc Natl Acad Sci U S A 92 (20), 9097-9101 (1995)
   PUBMED   7568080
REFERENCE   7  (residues 1 to 722)
  AUTHORS   Wen Z, Zhong Z and Darnell JE Jr.
  TITLE     Maximal activation of transcription by Stat1 and Stat3 requires
            both tyrosine and serine phosphorylation
  JOURNAL   Cell 82 (2), 241-250 (1995)
   PUBMED   7543024
REFERENCE   8  (residues 1 to 722)
  AUTHORS   Raz R, Durbin JE and Levy DE.
  TITLE     Acute phase response factor and additional members of the
            interferon-stimulated gene factor 3 family integrate diverse
            signals from cytokines, interferons, and growth factors
  JOURNAL   J Biol Chem 269 (39), 24391-24395 (1994)
   PUBMED   7523373
REFERENCE   9  (residues 1 to 722)
  AUTHORS   Zhong Z, Wen Z and Darnell JE Jr.
  TITLE     Stat3 and Stat4: members of the family of signal transducers and
            activators of transcription
  JOURNAL   Proc Natl Acad Sci U S A 91 (11), 4806-4810 (1994)
   PUBMED   7545930
REFERENCE   10 (residues 1 to 722)
  AUTHORS   Akira S, Nishio Y, Inoue M, Wang XJ, Wei S, Matsusaka T, Yoshida K,
            Sudo T, Naruto M and Kishimoto T.
  TITLE     Molecular cloning of APRF, a novel IFN-stimulated gene factor 3
            p91-related transcription factor involved in the gp130-mediated
            signaling pathway
  JOURNAL   Cell 77 (1), 63-71 (1994)
   PUBMED   7512451
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL591466.8.
            
            On Dec 7, 2005 this sequence version replaced XP_912491.1.
            
            Summary: The protein encoded by this gene is a member of the STAT
            protein family. In response to cytokines and growth factors, STAT
            family members are phosphorylated by the receptor associated
            kinases, and then form homo- or heterodimers that translocate to
            the cell nucleus where they act as transcription activators. This
            protein is activated through phosphorylation in response to various
            cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF,
            LIF and BMP2. This protein mediates the expression of a variety of
            genes in response to cell stimuli, and thus plays a key role in
            many cellular processes such as cell growth and apoptosis. The
            small GTPase Rac1 has been shown to bind and regulate the activity
            of this protein. PIAS3 protein is a specific inhibitor of this
            protein. Alternative splicing results in multiple transcript
            variants encoding distinct isoforms. [provided by RefSeq, Sep
            2015].
            
            Transcript Variant: This variant (3), also called Stat3B or
            Stat3beta, uses an alternate splice site in the 3' coding region,
            resulting in an early stop codon, compared to variant 1. The
            encoded isoform (3) has a shorter and distinct C-terminus, compared
            to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC019168.1, U30709.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..722
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 63.82 cM"
     Protein         1..722
                     /product="signal transducer and activator of transcription
                     3 isoform 3"
                     /note="acute phase response factor"
                     /calculated_mol_wt=82996
     Region          2..120
                     /region_name="STAT_int"
                     /note="STAT protein, protein interaction domain;
                     smart00964"
                     /db_xref="CDD:214942"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:P40763; propagated from
                     UniProtKB/Swiss-Prot (P42227.2)"
     Region          139..318
                     /region_name="STAT3_CCD"
                     /note="Coiled-coil domain of Signal Transducer and
                     Activator of Transcription 3 (STAT3); cd16853"
                     /db_xref="CDD:341078"
     Site            order(142..165,213..239,263..284)
                     /site_type="other"
                     /note="coiled-coil motif"
                     /db_xref="CDD:341078"
     Region          150..162
                     /region_name="Essential for nuclear import"
                     /note="propagated from UniProtKB/Swiss-Prot (P42227.2)"
     Site            214..215
                     /site_type="other"
                     /note="ligand inducing"
                     /db_xref="CDD:341078"
     Site            order(243,245,247..248,251..252,260..261,264,267..268,
                     271..272,275,278..279,313..314)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:341078"
     Region          321..484
                     /region_name="STAT3_DBD"
                     /note="DNA-binding domain of Signal Transducer and
                     Activator of Transcription 3 (STAT3); cd16847"
                     /db_xref="CDD:341085"
     Site            order(382,417,432,465..466,469)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:341085"
     Region          554..715
                     /region_name="SH2_STAT3"
                     /note="Src homology 2 (SH2) domain found in signal
                     transducer and activator of transcription (STAT) 3
                     proteins; cd10374"
                     /db_xref="CDD:198237"
     Site            order(591,609,636,638)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198237"
     Site            601
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P40763; propagated from
                     UniProtKB/Swiss-Prot (P42227.2)"
     Site            615
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P40763; propagated from
                     UniProtKB/Swiss-Prot (P42227.2)"
     Site            631
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P40763; propagated from
                     UniProtKB/Swiss-Prot (P42227.2)"
     Site            order(637,653)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198237"
     Site            order(647..648,710)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:198237"
     Site            685
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P40763; propagated from
                     UniProtKB/Swiss-Prot (P42227.2)"
     Site            705
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by FER and PTK6.
                     /evidence=ECO:0000269|PubMed:11294897,
                     ECO:0000269|PubMed:11553624, ECO:0007744|PubMed:18034455;
                     propagated from UniProtKB/Swiss-Prot (P42227.2)"
     Site            707
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P40763; propagated from
                     UniProtKB/Swiss-Prot (P42227.2)"
     Site            714
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P42227.2)"
     CDS             1..722
                     /gene="Stat3"
                     /gene_synonym="1110034C02Rik; Aprf"
                     /coded_by="NM_011486.5:309..2477"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS25441.1"
                     /db_xref="GeneID:20848"
                     /db_xref="MGI:MGI:103038"
ORIGIN      
        1 maqwnqlqql dtryleqlhq lysdsfpmel rqflapwies qdwayaaske shatlvfhnl
       61 lgeidqqysr flqesnvlyq hnlrrikqfl qsrylekpme iarivarclw eesrllqtaa
      121 taaqqggqan hptaavvtek qqmleqhlqd vrkrvqdleq kmkvvenlqd dfdfnyktlk
      181 sqgdmqdlng nnqsvtrqkm qqleqmltal dqmrrsivse lagllsamey vqktltdeel
      241 adwkrrqqia ciggppnicl drlenwitsl aesqlqtrqq ikkleelqqk vsykgdpivq
      301 hrpmleeriv elfrnlmksa fvverqpcmp mhpdrplvik tgvqfttkvr llvkfpelny
      361 qlkikvcidk dsgdvaalrg srkfnilgtn tkvmnmeesn ngslsaefkh ltlreqrcgn
      421 ggrancdasl ivteelhlit fetevyhqgl kidlethslp vvvisnicqm pnawasilwy
      481 nmltnnpknv nfftkppigt wdqvaevlsw qfssttkrgl sieqlttlae kllgpgvnys
      541 gcqitwakfc kenmagkgfs fwvwldniid lvkkyilalw negyimgfis kererailst
      601 kppgtfllrf sesskeggvt ftwvekdisg ktqiqsvepy tkqqlnnmsf aeiimgykim
      661 datnilvspl vylypdipke eafgkycrpe sqehpeadpg saapylktkf icvtpfidav
      721 wk
//
LOCUS       NP_032519                167 aa            linear   ROD 09-OCT-2023
DEFINITION  leptin precursor [Mus musculus].
ACCESSION   NP_032519
VERSION     NP_032519.1
DBSOURCE    REFSEQ: accession NM_008493.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 167)
  AUTHORS   Williamson A, da Silva A, do Carmo JM, Le Maitre CL, Hall JE and
            Aberdein N.
  TITLE     Impact of leptin deficiency on male tibia and vertebral body 3D
            bone architecture independent of changes in body weight
  JOURNAL   Physiol Rep 11 (19) (2023)
   PUBMED   37786973
  REMARK    GeneRIF: Impact of leptin deficiency on male tibia and vertebral
            body 3D bone architecture independent of changes in body weight.
REFERENCE   2  (residues 1 to 167)
  AUTHORS   Blandin A, Amosse J, Froger J, Hilairet G, Durcin M, Fizanne L,
            Ghesquiere V, Prieur X, Chaigneau J, Vergori L, Dray C, Pradere JP,
            Blandin S, Dupont J, Ducluzeau PH, Dubois S, Boursier J, Cariou B
            and Le Lay S.
  TITLE     Extracellular vesicles are carriers of adiponectin with
            insulin-sensitizing and anti-inflammatory properties
  JOURNAL   Cell Rep 42 (8), 112866 (2023)
   PUBMED   37605533
REFERENCE   3  (residues 1 to 167)
  AUTHORS   Kobiita A, Silva PN, Schmid MW and Stoffel M.
  TITLE     FoxM1 coordinates cell division, protein synthesis, and
            mitochondrial activity in a subset of beta cells during acute
            metabolic stress
  JOURNAL   Cell Rep 42 (8), 112986 (2023)
   PUBMED   37590136
REFERENCE   4  (residues 1 to 167)
  AUTHORS   Wang Y, Wan R and Hu C.
  TITLE     Leptin/obR signaling exacerbates obesity-related neutrophilic
            airway inflammation through inflammatory M1 macrophages
  JOURNAL   Mol Med 29 (1), 100 (2023)
   PUBMED   37488474
  REMARK    GeneRIF: Leptin/obR signaling exacerbates obesity-related
            neutrophilic airway inflammation through inflammatory M1
            macrophages.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 167)
  AUTHORS   Chan MP, Takenaka N and Satoh T.
  TITLE     Impaired Insulin Signaling Mediated by the Small GTPase Rac1 in
            Skeletal Muscle of the Leptin-Deficient Obese Mouse
  JOURNAL   Int J Mol Sci 24 (14), 11531 (2023)
   PUBMED   37511290
  REMARK    GeneRIF: Impaired Insulin Signaling Mediated by the Small GTPase
            Rac1 in Skeletal Muscle of the Leptin-Deficient Obese Mouse.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 167)
  AUTHORS   Thurlby,P.L. and Trayhurn,P.
  TITLE     The role of thermoregulatory thermogenesis in the development of
            obesity in genetically-obese (ob/ob) mice pair-fed with lean
            siblings
  JOURNAL   Br J Nutr 42 (3), 377-385 (1979)
   PUBMED   508700
REFERENCE   7  (residues 1 to 167)
  AUTHORS   Lin,M.H., Romsos,D.R., Akera,T. and Leveille,G.A.
  TITLE     Na+,K+-ATPase enzyme units in skeletal muscle and liver of
            14-day-old lean and obese (ob/ob) mice
  JOURNAL   Proc Soc Exp Biol Med 161 (3), 235-238 (1979)
   PUBMED   223169
REFERENCE   8  (residues 1 to 167)
  AUTHORS   Ruddle,N.H., Conta,B.S., Leinwand,L., Kozak,C., Ruddle,F.,
            Besmer,P. and Baltimore,D.
  TITLE     Assignment of the receptor for ecotropic murine leukemia virus to
            mouse chromosome 5
  JOURNAL   J Exp Med 148 (2), 451-465 (1978)
   PUBMED   212501
REFERENCE   9  (residues 1 to 167)
  AUTHORS   Coleman,D.L.
  TITLE     Obese and diabetes: two mutant genes causing diabetes-obesity
            syndromes in mice
  JOURNAL   Diabetologia 14 (3), 141-148 (1978)
   PUBMED   350680
  REMARK    Review article
REFERENCE   10 (residues 1 to 167)
  AUTHORS   Trayhurn,P. and James,W.P.
  TITLE     Thermoregulation and non-shivering thermogenesis in the genetically
            obese (ob/ob) mouse
  JOURNAL   Pflugers Arch 373 (2), 189-193 (1978)
   PUBMED   565045
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK030984.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030984.1, HQ166716.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..167
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 12.3 cM"
     Protein         1..167
                     /product="leptin precursor"
                     /note="obesity factor"
                     /calculated_mol_wt=16004
     sig_peptide     1..21
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=2722
     Region          26..167
                     /region_name="Leptin"
                     /note="pfam02024"
                     /db_xref="CDD:396559"
     CDS             1..167
                     /gene="Lep"
                     /gene_synonym="ob; obese"
                     /coded_by="NM_008493.3:60..563"
                     /db_xref="CCDS:CCDS19955.1"
                     /db_xref="GeneID:16846"
                     /db_xref="MGI:MGI:104663"
ORIGIN      
        1 mcwrplcrfl wlwsylsyvq avpiqkvqdd tktliktivt rindishtqs vsakqrvtgl
       61 dfipglhpil slskmdqtla vyqqvltslp sqnvlqiand lenlrdllhl lafskscslp
      121 qtsglqkpes ldgvleasly stevvalsrl qgslqdilqq ldvspec
//
LOCUS       NP_001034088            1164 aa            linear   ROD 09-OCT-2023
DEFINITION  phospholipid-transporting ATPase IA isoform a [Mus musculus].
ACCESSION   NP_001034088
VERSION     NP_001034088.1
DBSOURCE    REFSEQ: accession NM_001038999.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1164)
  AUTHORS   Xu H, Oses-Prieto JA, Khvotchev M, Jain S, Liang J, Burlingame A
            and Edwards RH.
  TITLE     Adaptor protein AP-3 produces synaptic vesicles that release at
            high frequency by recruiting phospholipid flippase ATP8A1
  JOURNAL   Nat Neurosci 26 (10), 1685-1700 (2023)
   PUBMED   37723322
  REMARK    GeneRIF: Adaptor protein AP-3 produces synaptic vesicles that
            release at high frequency by recruiting phospholipid flippase
            ATP8A1.
REFERENCE   2  (residues 1 to 1164)
  AUTHORS   Zheng L, Pan C, Tian W, Liang C, Feng Y, He W, Yang Z, Wang B, Qiu
            Q, Li N, Sun Y, Qiu H, Sample KM, Zhou L, Zhu X and Hu Y.
  TITLE     Atp8a1 deletion increases the proliferative activity of
            hematopoietic stem cells by impairing PTEN function
  JOURNAL   Cell Oncol (Dordr) 46 (4), 1069-1083 (2023)
   PUBMED   36930333
  REMARK    GeneRIF: Atp8a1 deletion increases the proliferative activity of
            hematopoietic stem cells by impairing PTEN function.
REFERENCE   3  (residues 1 to 1164)
  AUTHORS   Kook S, Wang P, Meng S, Jetter CS, Sucre JMS, Benjamin JT, Gokey
            JJ, Hanby HA, Jaume A, Goetzl L, Marks MS and Guttentag SH.
  TITLE     AP-3-dependent targeting of flippase ATP8A1 to lamellar bodies
            suppresses activation of YAP in alveolar epithelial type 2 cells
  JOURNAL   Proc Natl Acad Sci U S A 118 (20) (2021)
   PUBMED   33990468
REFERENCE   4  (residues 1 to 1164)
  AUTHORS   Yap YT, Li YH, Li W, Banerjee P and Zhang Z.
  TITLE     ATP8a1, an IFT27 binding partner, is dispensable for
            spermatogenesis and male fertility
  JOURNAL   Mol Reprod Dev 88 (5), 371-375 (2021)
   PUBMED   33821543
  REMARK    GeneRIF: ATP8a1, an IFT27 binding partner, is dispensable for
            spermatogenesis and male fertility.
REFERENCE   5  (residues 1 to 1164)
  AUTHORS   Jing W, Yabas M, Broer A, Coupland L, Gardiner EE, Enders A and
            Broer S.
  TITLE     Calpain cleaves phospholipid flippase ATP8A1 during apoptosis in
            platelets
  JOURNAL   Blood Adv 3 (3), 219-229 (2019)
   PUBMED   30674456
  REMARK    GeneRIF: ATP8A1 is cleaved by the cysteine protease calpain during
            apoptosis, and the cleavage is prevented indirectly by caspase
            inhibition, involving blockage of calcium influx into platelets and
            subsequent calpain activation.
REFERENCE   6  (residues 1 to 1164)
  AUTHORS   Wang L, Beserra C and Garbers DL.
  TITLE     A novel aminophospholipid transporter exclusively expressed in
            spermatozoa is required for membrane lipid asymmetry and normal
            fertilization
  JOURNAL   Dev Biol 267 (1), 203-215 (2004)
   PUBMED   14975727
  REMARK    GeneRIF: role in normal phospholipid distribution in the bilayer,
            and for normal binding, penetration, and signaling by the zona
            pellucida
REFERENCE   7  (residues 1 to 1164)
  AUTHORS   Ding J, Wu Z, Crider BP, Ma Y, Li X, Slaughter C, Gong L and Xie
            XS.
  TITLE     Identification and functional expression of four isoforms of ATPase
            II, the putative aminophospholipid translocase. Effect of isoform
            variation on the ATPase activity and phospholipid specificity
  JOURNAL   J Biol Chem 275 (30), 23378-23386 (2000)
   PUBMED   10801890
REFERENCE   8  (residues 1 to 1164)
  AUTHORS   Wang Y, Saigoh K, Osaka H, Yamanishi T, Suh J, Kiyosawa H, Sakai Y,
            Wakana S and Wada K.
  TITLE     YAC/BAC-based physical and transcript mapping around the gracile
            axonal dystrophy (gad) locus identifies Uchl1, Pmx2b, Atp3a2, and
            Hip2 genes
  JOURNAL   Genomics 66 (3), 333-336 (2000)
   PUBMED   10873389
REFERENCE   9  (residues 1 to 1164)
  AUTHORS   Halleck MS, Lawler JF JR, Blackshaw S, Gao L, Nagarajan P, Hacker
            C, Pyle S, Newman JT, Nakanishi Y, Ando H, Weinstock D, Williamson
            P and Schlegel RA.
  TITLE     Differential expression of putative transbilayer amphipath
            transporters
  JOURNAL   Physiol Genomics 1 (3), 139-150 (1999)
   PUBMED   11015572
  REMARK    Publication Status: Online-Only
REFERENCE   10 (residues 1 to 1164)
  AUTHORS   Halleck MS, Pradhan D, Blackman C, Berkes C, Williamson P and
            Schlegel RA.
  TITLE     Multiple members of a third subfamily of P-type ATPases identified
            by genomic sequences and ESTs
  JOURNAL   Genome Res 8 (4), 354-361 (1998)
   PUBMED   9548971
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK151709.1, AK045367.1, BC094235.1 and AC123662.13.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK220560.1, SRR10223970.7559.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1164
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 36.15 cM"
     Protein         1..1164
                     /product="phospholipid-transporting ATPase IA isoform a"
                     /EC_number="7.6.2.1"
                     /note="probable phospholipid-transporting ATPase IA;
                     chromaffin granule ATPase II; ATPase class I type 8A
                     member 1; ATPase 8A1, p type; ATPase 8A1,
                     aminophospholipid transporter (APLT), class I; P4-ATPase
                     flippase complex alpha subunit ATP8A1; ATPase,
                     aminophospholipid transporter (APLT), class I, type 8A,
                     member 1"
                     /calculated_mol_wt=131283
     Site            25
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19144319,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P70704.2)"
     Site            28
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:19144319, ECO:0007744|PubMed:21183079;
                     propagated from UniProtKB/Swiss-Prot (P70704.2)"
     Site            29
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:19144319, ECO:0007744|PubMed:21183079;
                     propagated from UniProtKB/Swiss-Prot (P70704.2)"
     Region          49..1086
                     /region_name="ATPase-Plipid"
                     /note="phospholipid-translocating P-type ATPase, flippase;
                     TIGR01652"
                     /db_xref="CDD:273734"
     Site            76..96
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P70704.2)"
     Site            101..121
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P70704.2)"
     Site            139
                     /site_type="cleavage"
                     /note="Cleavage, by calpain.
                     /evidence=ECO:0000305|PubMed:30674456; propagated from
                     UniProtKB/Swiss-Prot (P70704.2)"
     Site            298..318
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P70704.2)"
     Site            340..360
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P70704.2)"
     Site            352
                     /site_type="other"
                     /note="Involved in the recognition of the lipid substrate
                     on the exoplasmic side.
                     /evidence=ECO:0000250|UniProtKB:C7EXK4; propagated from
                     UniProtKB/Swiss-Prot (P70704.2)"
     Site            357
                     /site_type="other"
                     /note="Involved in the release of the transported lipid
                     into the cytosolic leaflet.
                     /evidence=ECO:0000250|UniProtKB:C7EXK4; propagated from
                     UniProtKB/Swiss-Prot (P70704.2)"
     Site            443
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P70704.2)"
     Site            867..887
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P70704.2)"
     Site            891..911
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P70704.2)"
     Site            940..960
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P70704.2)"
     Site            978..998
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P70704.2)"
     Site            1009..1029
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P70704.2)"
     Site            1045..1065
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P70704.2)"
     Site            1126
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P70704.2)"
     CDS             1..1164
                     /gene="Atp8a1"
                     /gene_synonym="APLT; Atp3a2; B230107D19Rik; ClassI"
                     /coded_by="NM_001038999.2:222..3716"
                     /note="isoform a is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS39104.1"
                     /db_xref="GeneID:11980"
                     /db_xref="MGI:MGI:1330848"
ORIGIN      
        1 mptmrrtvse irsraegyek tddvsektsl adqeevrtif inqpqltkfc nnhvstakyn
       61 vitflprfly sqfrraansf flfiallqqi pdvsptgryt tlvpllfila vaaikeiied
      121 ikrhkadnav nkkqtqvlrn gaweivhwek vavgeivkvt ngehlpadll slsssepqam
      181 cyietsnldg etnlkirqgl patsdikdid slmrisgrie cespnrhlyd fvgnirldgh
      241 gtvplgadqi llrgaqlrnt qwvhgivvyt ghdtklmqns tspplklsnv eritnvqili
      301 lfciliamsl vcsvgsaiwn rrhsgkdwyl hlhyggasnf glnfltfiil fnnlipisll
      361 vtlevvkftq ayfinwdldm hyeptdtaam artsnlneel gqvkyifsdk tgtltcnvmq
      421 fkkctiagva yghvpepedy gcspdewqss qfgdektfnd pslldnlqnn hptapiicef
      481 ltmmavchta vperegdkii yqaaspdega lvraakqlnf vftgrtpdsv iidslgqeer
      541 yellnvleft sarkrmsvvv rtpsgklrly ckgadtviye rlaetskyke itlkhleqfa
      601 teglrtlcfa vaeisesdfe ewravyhras tsvqnrllkl eesyeliekn lqllgataie
      661 dklqdqvpet ietlmkadik iwiltgdkqe tainighscr llkrnmgmiv inegsldgtr
      721 etlsrhcttl gdalrkendf aliidgktlk yaltfgvrqy fldlalscka viccrvsplq
      781 ksevvemvkk qvkvitlaig dgandvsmiq tahvgvgisg neglqaanss dysiaqfkyl
      841 knllmvhgaw nynrvskcil ycfyknivly iieiwfafvn gfsgqilfer wciglynvmf
      901 tamppltlgi ferscrkenm lkypelykts qnaldfntkv fwvhclnglf hsvilfwfpl
      961 kalqygtvfg ngktsdylll gnfvytfvvi tvclkaglet sywtwfshia iwgsialwvv
     1021 ffgiysslwp avpmapdmsg eaamlfssgv fwvgllsipv asllldvlyk vikrtafktl
     1081 vdevqeleak sqdpgavvlg kslteraqll knvfkknhvn lyrseslqqn llhgyafsqd
     1141 engivsqsev iraydttkqr pdew
//
LOCUS       NP_001278099             706 aa            linear   ROD 09-OCT-2023
DEFINITION  nuclear factor of activated T-cells, cytoplasmic 2 isoform g [Mus
            musculus].
ACCESSION   NP_001278099 XP_006498954
VERSION     NP_001278099.1
DBSOURCE    REFSEQ: accession NM_001291170.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 706)
  AUTHORS   Fu Y, Wang J, Liu C, Liao K, Gao X, Tang R, Fan B, Hong Y, Xiao N,
            Xiao C and Liu WH.
  TITLE     Glycogen synthase kinase 3 controls T-cell exhaustion by regulating
            NFAT activation
  JOURNAL   Cell Mol Immunol 20 (10), 1127-1139 (2023)
   PUBMED   37553428
  REMARK    GeneRIF: Glycogen synthase kinase 3 controls T-cell exhaustion by
            regulating NFAT activation.
REFERENCE   2  (residues 1 to 706)
  AUTHORS   Wan X, Zhao S, Dai Y, Zhang J, Shen Y, Gong L and Le Q.
  TITLE     WNT16b promotes the proliferation and self-renewal of human limbal
            epithelial stem/progenitor cells via activating the
            calcium/calcineurin A/NFATC2 pathway
  JOURNAL   Cell Prolif 56 (10), e13460 (2023)
   PUBMED   36974338
  REMARK    GeneRIF: WNT16b promotes the proliferation and self-renewal of
            human limbal epithelial stem/progenitor cells via activating the
            calcium/calcineurin A/NFATC2 pathway.
REFERENCE   3  (residues 1 to 706)
  AUTHORS   Jiang F, Guo Y, Hu L, Zhang M, Meng J, Si Y and Shi H.
  TITLE     Role of nuclear factor of activated T Cells-1 in Sepsis-induced
            behavioral deficits in mice
  JOURNAL   Brain Res 1806, 148299 (2023)
   PUBMED   36842570
REFERENCE   4  (residues 1 to 706)
  AUTHORS   Nagai J, Lin J and Boyce JA.
  TITLE     Macrophage P2Y6 Receptor Signaling Selectively Activates NFATC2 and
            Suppresses Allergic Lung Inflammation
  JOURNAL   J Immunol 209 (12), 2293-2303 (2022)
   PUBMED   36307120
  REMARK    GeneRIF: Macrophage P2Y6 Receptor Signaling Selectively Activates
            NFATC2 and Suppresses Allergic Lung Inflammation.
REFERENCE   5  (residues 1 to 706)
  AUTHORS   Zhu L, Zhou X, Gu M, Kim J, Li Y, Ko CJ, Xie X, Gao T, Cheng X and
            Sun SC.
  TITLE     Dapl1 controls NFATc2 activation to regulate CD8+ T cell exhaustion
            and responses in chronic infection and cancer
  JOURNAL   Nat Cell Biol 24 (7), 1165-1176 (2022)
   PUBMED   35773432
REFERENCE   6  (residues 1 to 706)
  AUTHORS   Vihma H, Pruunsild P and Timmusk T.
  TITLE     Alternative splicing and expression of human and mouse NFAT genes
  JOURNAL   Genomics 92 (5), 279-291 (2008)
   PUBMED   18675896
REFERENCE   7  (residues 1 to 706)
  AUTHORS   Ho SN, Thomas DJ, Timmerman LA, Li X, Francke U and Crabtree GR.
  TITLE     NFATc3, a lymphoid-specific NFATc family member that is
            calcium-regulated and exhibits distinct DNA binding specificity
  JOURNAL   J Biol Chem 270 (34), 19898-19907 (1995)
   PUBMED   7650004
REFERENCE   8  (residues 1 to 706)
  AUTHORS   Jain J, Burgeon E, Badalian TM, Hogan PG and Rao A.
  TITLE     A similar DNA-binding motif in NFAT family proteins and the Rel
            homology region
  JOURNAL   J Biol Chem 270 (8), 4138-4145 (1995)
   PUBMED   7876165
REFERENCE   9  (residues 1 to 706)
  AUTHORS   Li X, Ho SN, Luna J, Giacalone J, Thomas DJ, Timmerman LA, Crabtree
            GR and Francke U.
  TITLE     Cloning and chromosomal localization of the human and murine genes
            for the T-cell transcription factors NFATc and NFATp
  JOURNAL   Cytogenet Cell Genet 68 (3-4), 185-191 (1995)
   PUBMED   7842733
REFERENCE   10 (residues 1 to 706)
  AUTHORS   Ho AM, Jain J, Rao A and Hogan PG.
  TITLE     Expression of the transcription factor NFATp in a neuronal cell
            line and in the murine nervous system
  JOURNAL   J Biol Chem 269 (45), 28181-28186 (1994)
   PUBMED   7961754
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK044489.1, EU887589.1, EU887585.1 and BP757417.1.
            
            On Mar 27, 2014 this sequence version replaced XP_006498954.1.
            
            Transcript Variant: This variant (7, also known as IA-IIS-deltaXa)
            contains alternate 5' exon structure, and it thus differs in the 5'
            UTR and initiates translation at a downstream in-frame start codon,
            compared to variant 1. The encoded isoform (g) is shorter at the
            N-terminus, compared to isoform a. Both variants 7 and 14 encode
            isoform g.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU887589.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..706
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 88.91 cM"
     Protein         1..706
                     /product="nuclear factor of activated T-cells, cytoplasmic
                     2 isoform g"
                     /note="nuclear factor of activated T-cells, cytoplasmic 2;
                     NFAT pre-existing subunit; T-cell transcription factor
                     NFAT1"
                     /calculated_mol_wt=76835
     Region          179..353
                     /region_name="RHD-n_NFAT"
                     /note="N-terminal sub-domain of the Rel homology domain
                     (RHD) of nuclear factor of activated T-cells (NFAT)
                     proteins; cd07881"
                     /db_xref="CDD:143641"
     Site            order(202,205,207..208,210..212,260,301,303..304,318..319,
                     321,352)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143641"
     Region          358..458
                     /region_name="IPT_NFAT"
                     /note="IPT domain of the NFAT family of transcription
                     factors. NFAT transcription complexes are a target of
                     calcineurin, a calcium dependent phosphatase, and activate
                     genes mainly involved in cell-cell-interaction; cd01178"
                     /db_xref="CDD:238583"
     Site            order(382,446)
                     /site_type="DNA binding"
                     /note="DNA binding sites [nucleotide binding]"
                     /db_xref="CDD:238583"
     CDS             1..706
                     /gene="Nfatc2"
                     /gene_synonym="NF-ATc2; NF-ATp; NFAT1; NFAT1-D; Nfatp"
                     /coded_by="NM_001291170.1:203..2323"
                     /note="isoform g is encoded by transcript variant 7"
                     /db_xref="GeneID:18019"
                     /db_xref="MGI:MGI:102463"
ORIGIN      
        1 msprtslaed sclgrhspvp rpasrssspg akrrhscaea lvaplpaasp qrsrspspqp
       61 sphvalqdds ipagypptag savlmdalnt latdspcgip skiwktspdp tpvstapska
      121 glarhiyptv eflgpceqee rrnsapesil lvpptwpkql vpaipicsip vtaslpplew
      181 plsnqsgsye lrievqpkph hrahyetegs rgavkaptgg hpvvqlhgym enkplglqif
      241 igtaderilk phafyqvhri tgktvtttsy ekivgntkvl eiplepknnm ratidcagil
      301 klrnadielr kgetdigrkn trvrlvfrvh vpepsgrivs lqaasnpiec sqrsahelpm
      361 verqdmdscl vyggqqmilt gqnftaeskv vfmekttdgq qiwemeatvd kdksqpnmlf
      421 veipeyrnkh irvpvkvnfy vingkrkrsq pqhftyhpvp aiktepsdey epslicspah
      481 gglgsqpyyp qhpmlaesps clvatmapcq qfrsglsspd aryqqqspaa alyqrsksls
      541 pgllgyqqps llaaplglad ahrsvlvhag sqgqgqgstl phtssasqqa spvihysptn
      601 qqlrggghqe fqhimycenf gpssarpgpp pinqgqrlsp gayptviqqq tapsqraakn
      661 gpsdqkealp tgvtvkqeqn ldqtylddvn eiirkefsgp psrnqt
//
LOCUS       NP_062263                462 aa            linear   ROD 09-OCT-2023
DEFINITION  prelamin-A/C isoform C2 [Mus musculus].
ACCESSION   NP_062263
VERSION     NP_062263.1
DBSOURCE    REFSEQ: accession NM_019390.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 462)
  AUTHORS   Kim JR, Kim PH, Presnell A, Tu Y and Young SG.
  TITLE     Revisiting the truncated lamin A produced by a commonly used strain
            of Lmna knockout mice
  JOURNAL   Nucleus 14 (1), 2262308 (2023)
   PUBMED   37754663
  REMARK    GeneRIF: Revisiting the truncated lamin A produced by a commonly
            used strain of Lmna knockout mice.
REFERENCE   2  (residues 1 to 462)
  AUTHORS   Chang L, Huang R, Chen J, Li G, Shi G, Xu B and Wang L.
  TITLE     An alpha-helix variant p.Arg156Pro in LMNA as a cause of hereditary
            dilated cardiomyopathy: genetics and bioinfomatics exploration
  JOURNAL   BMC Med Genomics 16 (1), 229 (2023)
   PUBMED   37784143
  REMARK    GeneRIF: An alpha-helix variant p.Arg156Pro in LMNA as a cause of
            hereditary dilated cardiomyopathy: genetics and bioinfomatics
            exploration.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 462)
  AUTHORS   Pruvost M, Patzig J, Yattah C, Selcen I, Hernandez M, Park HJ,
            Moyon S, Liu S, Morioka MS, Shopland L, Al-Dalahmah O, Bendl J,
            Fullard JF, Roussos P, Goldman J, He Y, Dupree JL and Casaccia P.
  TITLE     The stability of the myelinating oligodendrocyte transcriptome is
            regulated by the nuclear lamina
  JOURNAL   Cell Rep 42 (8), 112848 (2023)
   PUBMED   37515770
REFERENCE   4  (residues 1 to 462)
  AUTHORS   Jahn D, Schramm S, Benavente R and Alsheimer M.
  TITLE     Dynamic properties of meiosis-specific lamin C2 and its impact on
            nuclear envelope integrity
  JOURNAL   Nucleus 1 (3), 273-283 (2010)
   PUBMED   21327075
  REMARK    GeneRIF: lamin C2 as a 'natural lamin deletion mutant' that confers
            unique properties to the nuclear envelope which would be essential
            for dynamic telomere repositioning during meiotic prophase I
REFERENCE   5  (residues 1 to 462)
  AUTHORS   Sullivan T, Escalante-Alcalde D, Bhatt H, Anver M, Bhat N,
            Nagashima K, Stewart CL and Burke B.
  TITLE     Loss of A-type lamin expression compromises nuclear envelope
            integrity leading to muscular dystrophy
  JOURNAL   J Cell Biol 147 (5), 913-920 (1999)
   PUBMED   10579712
REFERENCE   6  (residues 1 to 462)
  AUTHORS   Eggert M, Radomski N, Tripier D, Traub P and Jost E.
  TITLE     Identification of phosphorylation sites on murine nuclear lamin C
            by RP-HPLC and microsequencing
  JOURNAL   FEBS Lett 292 (1-2), 205-209 (1991)
   PUBMED   1959608
REFERENCE   7  (residues 1 to 462)
  AUTHORS   Weber K, Plessmann U and Traub P.
  TITLE     Maturation of nuclear lamin A involves a specific carboxy-terminal
            trimming, which removes the polyisoprenylation site from the
            precursor; implications for the structure of the nuclear lamina
  JOURNAL   FEBS Lett 257 (2), 411-414 (1989)
   PUBMED   2583287
REFERENCE   8  (residues 1 to 462)
  AUTHORS   Riedel W and Werner D.
  TITLE     Nucleotide sequence of the full-length mouse lamin C cDNA and its
            deduced amino-acid sequence
  JOURNAL   Biochim Biophys Acta 1008 (1), 119-122 (1989)
   PUBMED   2719959
REFERENCE   9  (residues 1 to 462)
  AUTHORS   Rober RA, Weber K and Osborn M.
  TITLE     Differential timing of nuclear lamin A/C expression in the various
            organs of the mouse embryo and the young animal: a developmental
            study
  JOURNAL   Development 105 (2), 365-378 (1989)
   PUBMED   2680424
REFERENCE   10 (residues 1 to 462)
  AUTHORS   Houliston E, Guilly MN, Courvalin JC and Maro B.
  TITLE     Expression of nuclear lamins during mouse preimplantation
            development
  JOURNAL   Development 102 (2), 271-278 (1988)
   PUBMED   3046911
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC145168.5, BY140664.1 and
            AC102388.7.
            
            Summary: This gene encodes a protein that is a member of the lamin
            family. Nuclear lamins, intermediate filament-like proteins, are
            the major components of the nuclear lamina, a protein meshwork
            associated with the inner nuclear membrane. This meshwork is
            thought to maintain the integrity of the nuclear envelope,
            participate in chromatin organization, and regulate gene
            transcription. Vertebrate lamins consist of two types, A and B.
            This protein is an A-type and is proposed to be developmentally
            regulated. In mouse deficiency of this gene is associated with
            muscular dystrophy. Mouse lines with different mutations in this
            gene serve as pathophysiological models for several human
            laminopathies. In humans, mutations in this gene lead to several
            diseases: Emery-Dreifuss muscular dystrophy, familial partial
            lipodystrophy, limb girdle muscular dystrophy, dilated
            cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford
            progeria syndrome. Alternative splicing results in multiple
            transcript variants that encode different protein isoforms.
            [provided by RefSeq, May 2013].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and 5'
            coding region, uses an alternate start codon, and uses an alternate
            3' structure, and thus differs in the 3' coding region and 3' UTR,
            compared to variant 1. The encoded isoform (C2) has distinct N- and
            C-termini and is shorter than isoform A.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D14850.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..462
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 38.84 cM"
     Protein         1..462
                     /product="prelamin-A/C isoform C2"
                     /note="prelamin-A/C; lamin-A/C; lamin C"
                     /calculated_mol_wt=52521
     Region          5..274
                     /region_name="Filament"
                     /note="Intermediate filament protein; pfam00038"
                     /db_xref="CDD:425436"
     Region          322..429
                     /region_name="LTD"
                     /note="Lamin Tail Domain; pfam00932"
                     /db_xref="CDD:425951"
     CDS             1..462
                     /gene="Lmna"
                     /gene_synonym="Dhe"
                     /coded_by="NM_019390.3:57..1445"
                     /note="isoform C2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS38483.1"
                     /db_xref="GeneID:16905"
                     /db_xref="MGI:MGI:96794"
ORIGIN      
        1 mgnaegrntk kegdllaaqa rlkdlealln skeaalstal sekrtlegel hdlrgqvakl
       61 eaalgeakkq lqdemlrrvd aenrlqtlke eldfqkniys eelretkrrh etrlveidng
      121 kqrefesrla dalqelraqh edqveqykke lektysakld narqsaerns nlvgaaheel
      181 qqsriridsl saqlsqlqkq laakeaklrd ledslarerd tsrrllaeke remaemrarm
      241 qqqldeyqel ldiklaldme ihayrklleg eeerlrlsps ptsqrsrgra sshssqsqgg
      301 gsvtkkrkle ssesrssfsq hartsgrvav eevdeegkfv rlrnksnedq smgnwqirrq
      361 ngddplmtyr fppkftlkag qvvtiwasga gathspptdl vwkaqntwgc gsslrtalin
      421 stgeevamrk lvrsltmved nedddedgee llhhhrvsgs rr
//
LOCUS       NP_035393               1082 aa            linear   ROD 09-OCT-2023
DEFINITION  RE1-silencing transcription factor [Mus musculus].
ACCESSION   NP_035393
VERSION     NP_035393.2
DBSOURCE    REFSEQ: accession NM_011263.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1082)
  AUTHORS   Carvalho LB, Dos Santos Sanna PL, Dos Santos Afonso CC, Bondan EF,
            da Silva Feltran G, Ferreira MR, Birbrair A, Andia DC, Latini A and
            Foganholi da Silva RA.
  TITLE     MicroRNA biogenesis machinery activation and lncRNA and REST
            overexpression as neuroprotective responses to fight inflammation
            in the hippocampus
  JOURNAL   J Neuroimmunol 382, 578149 (2023)
   PUBMED   37481910
  REMARK    GeneRIF: MicroRNA biogenesis machinery activation and lncRNA and
            REST overexpression as neuroprotective responses to fight
            inflammation in the hippocampus.
REFERENCE   2  (residues 1 to 1082)
  AUTHORS   Yamato E.
  TITLE     Aberrant Expression of Rest4 Gene in Low-Functioning Pancreatic
            Beta Cell Line
  JOURNAL   Horm Metab Res 55 (6), 426-431 (2023)
   PUBMED   36758614
  REMARK    GeneRIF: Aberrant Expression of Rest4 Gene in Low-Functioning
            Pancreatic Beta Cell Line.
REFERENCE   3  (residues 1 to 1082)
  AUTHORS   Karapurkar JK, Kim MS, Colaco JC, Suresh B, Sarodaya N, Kim DH,
            Park CH, Hong SH, Kim KS and Ramakrishna S.
  TITLE     CRISPR/Cas9-based genome-wide screening of the deubiquitinase
            subfamily identifies USP3 as a protein stabilizer of REST blocking
            neuronal differentiation and promotes neuroblastoma tumorigenesis
  JOURNAL   J Exp Clin Cancer Res 42 (1), 121 (2023)
   PUBMED   37170124
  REMARK    GeneRIF: CRISPR/Cas9-based genome-wide screening of the
            deubiquitinase subfamily identifies USP3 as a protein stabilizer of
            REST blocking neuronal differentiation and promotes neuroblastoma
            tumorigenesis.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1082)
  AUTHORS   Rigkou A, Magyar A, Speer JM and Roussa E.
  TITLE     TGF-beta2 Regulates Transcription of the K+/Cl- Cotransporter 2
            (KCC2) in Immature Neurons and Its Phosphorylation at T1007 in
            Differentiated Neurons
  JOURNAL   Cells 11 (23), 3861 (2022)
   PUBMED   36497119
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1082)
  AUTHORS   Cloud AS, Koohestani F, McWilliams MM, Ganeshkumar S, Gunewardena
            S, Graham A, Nothnick WB and Chennathukuzhi VM.
  TITLE     Loss of the repressor REST affects progesterone receptor function
            and promotes uterine leiomyoma pathogenesis
  JOURNAL   Proc Natl Acad Sci U S A 119 (44), e2205524119 (2022)
   PUBMED   36282915
  REMARK    GeneRIF: Loss of the repressor REST affects progesterone receptor
            function and promotes uterine leiomyoma pathogenesis.
REFERENCE   6  (residues 1 to 1082)
  AUTHORS   Edlund T and Jessell TM.
  TITLE     Progression from extrinsic to intrinsic signaling in cell fate
            specification: a view from the nervous system
  JOURNAL   Cell 96 (2), 211-224 (1999)
   PUBMED   9988216
  REMARK    Review article
REFERENCE   7  (residues 1 to 1082)
  AUTHORS   Ko MS, Threat TA, Wang X, Horton JH, Cui Y, Wang X, Pryor E, Paris
            J, Wells-Smith J, Kitchen JR, Rowe LB, Eppig J, Satoh T, Brant L,
            Fujiwara H, Yotsumoto S and Nakashima H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
REFERENCE   8  (residues 1 to 1082)
  AUTHORS   Chen ZF, Paquette AJ and Anderson DJ.
  TITLE     NRSF/REST is required in vivo for repression of multiple neuronal
            target genes during embryogenesis
  JOURNAL   Nat Genet 20 (2), 136-142 (1998)
   PUBMED   9771705
REFERENCE   9  (residues 1 to 1082)
  AUTHORS   Chong JA, Tapia-Ramirez J, Kim S, Toledo-Aral JJ, Zheng Y, Boutros
            MC, Altshuller YM, Frohman MA, Kraner SD and Mandel G.
  TITLE     REST: a mammalian silencer protein that restricts sodium channel
            gene expression to neurons
  JOURNAL   Cell 80 (6), 949-957 (1995)
   PUBMED   7697725
REFERENCE   10 (residues 1 to 1082)
  AUTHORS   Schoenherr CJ and Anderson DJ.
  TITLE     The neuron-restrictive silencer factor (NRSF): a coordinate
            repressor of multiple neuron-specific genes
  JOURNAL   Science 267 (5202), 1360-1363 (1995)
   PUBMED   7871435
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK004945.2, BC127065.1, BE132774.1 and AI121875.1.
            
            On Jul 24, 2009 this sequence version replaced NP_035393.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004945.2, AK156514.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1082
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 41.61 cM"
     Protein         1..1082
                     /product="RE1-silencing transcription factor"
                     /note="neural-restrictive silencer factor"
                     /calculated_mol_wt=117653
     Region          32..117
                     /region_name="Interaction with SIN3A.
                     /evidence=ECO:0000250|UniProtKB:Q13127"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VIG1.2)"
     Region          43..57
                     /region_name="Interaction with SIN3B.
                     /evidence=ECO:0000250|UniProtKB:Q13127"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VIG1.2)"
     Region          140..413
                     /region_name="Interaction with ZFP90.
                     /evidence=ECO:0000250|UniProtKB:Q13127"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VIG1.2)"
     Region          196..207
                     /region_name="Required for binding to the
                     neuron-restrictive silencer element.
                     /evidence=ECO:0000269|PubMed:11039732"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VIG1.2)"
     Region          245..265
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          <266..409
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          273..293
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(278,280,282,284..285,288..289,292,306,308,312..313,
                     316..317,320,334,336,338,340..341,344..345,349)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          285..310
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:433230"
     Region          299..323
                     /region_name="zf-H2C2_5"
                     /note="C2H2-type zinc-finger domain; pfam13909"
                     /db_xref="CDD:404746"
     Region          301..321
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          313..338
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:433230"
     Region          329..350
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          386..402
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          408..809
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VIG1.2)"
     Region          <607..776
                     /region_name="PRK12323"
                     /note="DNA polymerase III subunit gamma/tau"
                     /db_xref="CDD:237057"
     Region          831..1027
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VIG1.2)"
     Site            950
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O54963; propagated from
                     UniProtKB/Swiss-Prot (Q8VIG1.2)"
     Region          985..1063
                     /region_name="Interaction with RCOR1.
                     /evidence=ECO:0000250|UniProtKB:Q13127"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VIG1.2)"
     CDS             1..1082
                     /gene="Rest"
                     /gene_synonym="2610008J04Rik; NRSF; REST4"
                     /coded_by="NM_011263.2:305..3553"
                     /db_xref="CCDS:CCDS19372.1"
                     /db_xref="GeneID:19712"
                     /db_xref="MGI:MGI:104897"
ORIGIN      
        1 matqvmgqss gggslfnnsa nmgmaltndm ydlhelskae laapqlimla nvaltgeasg
       61 sccdylvgee rqmaelmpvg dnhfsesege gleesadlkg lenmelgsle lsavepqpvf
      121 easaapeiys ankdpapetp vaedkcrssk akpfrckpcq yeaeseeqfv hhirihsakk
      181 ffveesaekq akawesgssp aeegefskgp ircdrcgynt nrydhymahl khhlragene
      241 riykciicty ttvseyhwrk hlrnhfprkv ytcskcnyfs drknnyvqhv rthtgerpyk
      301 celcpysssq kthltrhmrt hsgekpfkcd qcnyvasnqh evtrharqvh ngpkplncph
      361 cdyktadrsn fkkhvelhvn prqfncpvcd yaaskkcnlq yhfkskhptc psktmdvskv
      421 klkktkkrea dllnnavsne kmeneqtktk gdvsgkknek pvkavgkdas kekkpgssvs
      481 vvqvttrtrk savaaetkaa evkhtdgqtg nnpekpckak knkrkkdaea hpseepvneg
      541 pvtkkkkkse ckskigtnvp kgggraeerp gvkkqsaslk kgtkktppkt ktskkggkla
      601 pkgmgqteps sgalaqvgvs pdpaliqaev tgsgssqtel pspmdiakse paqmevsltg
      661 pppvepaqme pspakppqve aptypqppqr gpapptgpap ptgpapptep apptglaeme
      721 psptepsqke pppsmeppcp eelpqaeppp medcqkelps pvepaqieva qtaptqvqee
      781 pppvsepprv kptkrsslrk draekelsll semarqeqvl mgvglvpvrd skllkgnksa
      841 qdppappsps pkgnsreetp kdqemvsdge gtivfplkkg gpeeagespa elaalkesar
      901 vssseqnsam peggashskc qtgssglcdv dteqktdtvp mkdsaaepvs pptptvdrda
      961 gspavvaspp itlaenesqe idedegihsh dgsdlsdnms egsddsglhg arptppeats
     1021 kngkaglagk vtegefvcif cdrsfrkekd yskhlnrhlv nvyfleeaae eqeeqeeree
     1081 qe
//
LOCUS       NP_034350                456 aa            linear   ROD 09-OCT-2023
DEFINITION  peptidyl-prolyl cis-trans isomerase FKBP5 [Mus musculus].
ACCESSION   NP_034350
VERSION     NP_034350.1
DBSOURCE    REFSEQ: accession NM_010220.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 456)
  AUTHORS   Song Q, Song C, Chen X, Xiong Y, Li L, Liao W, Xue L and Yang S.
  TITLE     FKBP5 deficiency attenuates calcium oxalate kidney stone formation
            by suppressing cell-crystal adhesion, apoptosis and macrophage M1
            polarization via inhibition of NF-kappaB signaling
  JOURNAL   Cell Mol Life Sci 80 (10), 301 (2023)
   PUBMED   37740796
  REMARK    GeneRIF: FKBP5 deficiency attenuates calcium oxalate kidney stone
            formation by suppressing cell-crystal adhesion, apoptosis and
            macrophage M1 polarization via inhibition of NF-kappaB signaling.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 456)
  AUTHORS   Wang X, Song J, Yuan Y, Li L, Abu-Taha I, Heijman J, Sun L, Dobrev
            S, Kamler M, Xie L, Wehrens XHT, Horrigan FT, Dobrev D and Li N.
  TITLE     Downregulation of FKBP5 Promotes Atrial Arrhythmogenesis
  JOURNAL   Circ Res 133 (1), e1-e16 (2023)
   PUBMED   37154033
  REMARK    GeneRIF: Downregulation of FKBP5 Promotes Atrial Arrhythmogenesis.
REFERENCE   3  (residues 1 to 456)
  AUTHORS   Brix LM, Toksoz I, Aman L, Kovarova V, Springer M, Bordes J, van
            Doeselaar L, Engelhardt C, Hausl AS, Narayan S, Sterlemann V, Yang
            H, Deussing JM and Schmidt MV.
  TITLE     Contribution of the co-chaperone FKBP51 in the ventromedial
            hypothalamus to metabolic homeostasis in male and female mice
  JOURNAL   Mol Metab 65, 101579 (2022)
   PUBMED   36007872
  REMARK    GeneRIF: Contribution of the co-chaperone FKBP51 in the
            ventromedial hypothalamus to metabolic homeostasis in male and
            female mice.
REFERENCE   4  (residues 1 to 456)
  AUTHORS   Bajaj T, Hausl AS, Schmidt MV and Gassen NC.
  TITLE     FKBP5/FKBP51 on weight watch: central FKBP5 links regulatory WIPI
            protein networks to autophagy and metabolic control
  JOURNAL   Autophagy 18 (11), 2756-2758 (2022)
   PUBMED   35438043
  REMARK    GeneRIF: FKBP5/FKBP51 on weight watch: central FKBP5 links
            regulatory WIPI protein networks to autophagy and metabolic
            control.
REFERENCE   5  (residues 1 to 456)
  AUTHORS   Gan YL, Wang CY, He RH, Hsu PC, Yeh HH, Hsieh TH, Lin HC, Cheng MY,
            Jeng CJ, Huang MC and Lee YH.
  TITLE     FKBP51 mediates resilience to inflammation-induced anxiety through
            regulation of glutamic acid decarboxylase 65 expression in mouse
            hippocampus
  JOURNAL   J Neuroinflammation 19 (1), 152 (2022)
   PUBMED   35705957
  REMARK    GeneRIF: FKBP51 mediates resilience to inflammation-induced anxiety
            through regulation of glutamic acid decarboxylase 65 expression in
            mouse hippocampus.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 456)
  AUTHORS   Wang HY, Arden KC, Bermingham JR Jr, Viars CS, Lin W, Boyer AD and
            Fu XD.
  TITLE     Localization of serine kinases, SRPK1 (SFRSK1) and SRPK2 (SFRSK2),
            specific for the SR family of splicing factors in mouse and human
            chromosomes
  JOURNAL   Genomics 57 (2), 310-315 (1999)
   PUBMED   10198174
REFERENCE   7  (residues 1 to 456)
  AUTHORS   Nair SC, Rimerman RA, Toran EJ, Chen S, Prapapanich V, Butts RN and
            Smith DF.
  TITLE     Molecular cloning of human FKBP51 and comparisons of immunophilin
            interactions with Hsp90 and progesterone receptor
  JOURNAL   Mol Cell Biol 17 (2), 594-603 (1997)
   PUBMED   9001212
REFERENCE   8  (residues 1 to 456)
  AUTHORS   Yeh WC, Li TK, Bierer BE and McKnight SL.
  TITLE     Identification and characterization of an immunophilin expressed
            during the clonal expansion phase of adipocyte differentiation
  JOURNAL   Proc Natl Acad Sci U S A 92 (24), 11081-11085 (1995)
   PUBMED   7479941
REFERENCE   9  (residues 1 to 456)
  AUTHORS   Baughman G, Wiederrecht GJ, Campbell NF, Martin MM and Bourgeois S.
  TITLE     FKBP51, a novel T-cell-specific immunophilin capable of calcineurin
            inhibition
  JOURNAL   Mol Cell Biol 15 (8), 4395-4402 (1995)
   PUBMED   7542743
REFERENCE   10 (residues 1 to 456)
  AUTHORS   Baughman G, Harrigan MT, Campbell NF, Nurrish SJ and Bourgeois S.
  TITLE     Genes newly identified as regulated by glucocorticoids in murine
            thymocytes
  JOURNAL   Mol Endocrinol 5 (5), 637-644 (1991)
   PUBMED   2072923
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY740772.1, BU613862.1, CF949740.1 and AC154912.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U16959.1, SRR7974084.6335.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..456
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 14.66 cM"
     Protein         1..456
                     /product="peptidyl-prolyl cis-trans isomerase FKBP5"
                     /EC_number="5.2.1.8"
                     /note="rotamase; 51 kDa FK506-binding protein; 51 kDa
                     FKBP; PPIase FKBP5"
                     /calculated_mol_wt=50835
     Region          1..24
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64378.1)"
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:Q13451; propagated from
                     UniProtKB/Swiss-Prot (Q64378.1)"
     Site            28
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q13451; propagated from
                     UniProtKB/Swiss-Prot (Q64378.1)"
     Region          44..135
                     /region_name="FKBP_C"
                     /note="FKBP-type peptidyl-prolyl cis-trans isomerase;
                     pfam00254"
                     /db_xref="CDD:425560"
     Site            155
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q13451; propagated from
                     UniProtKB/Swiss-Prot (Q64378.1)"
     Region          <230..>397
                     /region_name="3a0801s09"
                     /note="mitochondrial precursor proteins import receptor
                     (72 kDa mitochondrial outermembrane protein)
                     (mitochondrial import receptor for the ADP/ATP carrier)
                     (translocase of outermembrane tom70); TIGR00990"
                     /db_xref="CDD:273380"
     Region          268..301
                     /region_name="TPR 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64378.1)"
     Region          268..296
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          317..350
                     /region_name="TPR 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64378.1)"
     Region          319..345
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(321..322,325..326,328,352,355..356,359..360,
                     362..363,386,389..390,393..394,397)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          350..380
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          351..384
                     /region_name="TPR 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64378.1)"
     Region          421..456
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64378.1)"
     Site            444
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13451; propagated from
                     UniProtKB/Swiss-Prot (Q64378.1)"
     CDS             1..456
                     /gene="Fkbp5"
                     /gene_synonym="D17Ertd592e; Dit1; FKBP-5; FKBP51"
                     /coded_by="NM_010220.4:220..1590"
                     /db_xref="CCDS:CCDS37528.1"
                     /db_xref="GeneID:14229"
                     /db_xref="MGI:MGI:104670"
ORIGIN      
        1 mttdegtsnn genpaatmte qgedittkkd rgvlkivkrv gtsdeapmfg dkvyvhykgm
       61 lsdgkkfdss hdrkkpfafs lgqgqvikaw digvstmkkg eichllckpe yaygsaghlq
      121 kipsnatlff eielldfkge dlfedsgvir rikrkgegys npnegatvkv hlegccggrt
      181 fdcrdvvfvv gegedhdipi gidkalvkmq reeqcilylg prygfgeagk pkfgidpnae
      241 lmyevtlksf ekakeswemd tkekltqaai vkekgtvyfk ggkytqaviq yrkivswlem
      301 eyglsekesk asesfllaaf lnlamcylkl reynkavecc dkalgldsan ekglyrrgea
      361 qllmndfesa kgdfekvlav npqnraarlq ismcqrkake hnerdrrvya nmfkkfaerd
      421 akeeaskags kkavegaagk qhesqameeg kakghv
//
LOCUS       NP_001076589             785 aa            linear   ROD 09-OCT-2023
DEFINITION  protein enabled homolog isoform 3 [Mus musculus].
ACCESSION   NP_001076589
VERSION     NP_001076589.1
DBSOURCE    REFSEQ: accession NM_001083120.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 785)
  AUTHORS   Yun S, Cha SS and Kim JH.
  TITLE     DJ-1 promotes cell migration by interacting with Mena, the
            mammalian homolog of Drosophila enabled
  JOURNAL   Adv Biol Regul 88, 100943 (2023)
   PUBMED   36542983
  REMARK    GeneRIF: DJ-1 promotes cell migration by interacting with Mena, the
            mammalian homolog of Drosophila enabled.
REFERENCE   2  (residues 1 to 785)
  AUTHORS   Wang W, Taufalele PV, Millet M, Homsy K, Smart K, Berestesky ED,
            Schunk CT, Rowe MM, Bordeleau F and Reinhart-King CA.
  TITLE     Matrix stiffness regulates tumor cell intravasation through
            expression and ESRP1-mediated alternative splicing of MENA
  JOURNAL   Cell Rep 42 (4), 112338 (2023)
   PUBMED   37027295
  REMARK    GeneRIF: Matrix stiffness regulates tumor cell intravasation
            through expression and ESRP1-mediated alternative splicing of MENA.
REFERENCE   3  (residues 1 to 785)
  AUTHORS   Borriello L, Coste A, Traub B, Sharma VP, Karagiannis GS, Lin Y,
            Wang Y, Ye X, Duran CL, Chen X, Friedman M, Sosa MS, Sun D, Dalla
            E, Singh DK, Oktay MH, Aguirre-Ghiso JA, Condeelis JS and Entenberg
            D.
  TITLE     Primary tumor associated macrophages activate programs of invasion
            and dormancy in disseminating tumor cells
  JOURNAL   Nat Commun 13 (1), 626 (2022)
   PUBMED   35110548
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 785)
  AUTHORS   Hooper JE, Jones KL, Smith FJ, Williams T and Li H.
  TITLE     An Alternative Splicing Program for Mouse Craniofacial Development
  JOURNAL   Front Physiol 11, 1099 (2020)
   PUBMED   33013468
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 785)
  AUTHORS   Lee S, Sears MJ, Zhang Z, Li H, Salhab I, Krebs P, Xing Y, Nah HD,
            Williams T and Carstens RP.
  TITLE     Cleft lip and cleft palate in Esrp1 knockout mice is associated
            with alterations in epithelial-mesenchymal crosstalk
  JOURNAL   Development 147 (21) (2020)
   PUBMED   32253237
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 785)
  AUTHORS   Ermekova KS, Zambrano N, Linn H, Minopoli G, Gertler F, Russo T and
            Sudol M.
  TITLE     The WW domain of neural protein FE65 interacts with proline-rich
            motifs in Mena, the mammalian homolog of Drosophila enabled
  JOURNAL   J Biol Chem 272 (52), 32869-32877 (1997)
   PUBMED   9407065
REFERENCE   7  (residues 1 to 785)
  AUTHORS   Bedford MT, Chan DC and Leder P.
  TITLE     FBP WW domains and the Abl SH3 domain bind to a specific class of
            proline-rich ligands
  JOURNAL   EMBO J 16 (9), 2376-2383 (1997)
   PUBMED   9171351
REFERENCE   8  (residues 1 to 785)
  AUTHORS   Yamabhai M and Kay BK.
  TITLE     Examining the specificity of Src homology 3 domain--ligand
            interactions with alkaline phosphatase fusion proteins
  JOURNAL   Anal Biochem 247 (1), 143-151 (1997)
   PUBMED   9126384
REFERENCE   9  (residues 1 to 785)
  AUTHORS   Gertler FB, Niebuhr K, Reinhard M, Wehland J and Soriano P.
  TITLE     Mena, a relative of VASP and Drosophila Enabled, is implicated in
            the control of microfilament dynamics
  JOURNAL   Cell 87 (2), 227-239 (1996)
   PUBMED   8861907
REFERENCE   10 (residues 1 to 785)
  AUTHORS   Sazuka T, Tomooka Y, Kathju S, Ikawa Y, Noda M and Kumar S.
  TITLE     Identification of a developmentally regulated gene in the mouse
            central nervous system which encodes a novel proline rich protein
  JOURNAL   Biochim Biophys Acta 1132 (3), 240-248 (1992)
   PUBMED   1420303
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122204.3 and AC165229.7.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U72521.1, SRR7974084.11762.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164141 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..785
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 84.93 cM"
     Protein         1..785
                     /product="protein enabled homolog isoform 3"
                     /note="protein enabled homolog; NPC derived proline rich
                     protein 1"
                     /calculated_mol_wt=83854
     Region          5..112
                     /region_name="EVH1_Ena_VASP-like"
                     /note="Enabled/VASP family EVH1 domain; cd01207"
                     /db_xref="CDD:269918"
     Site            order(16,23,69,71,77,79,81)
                     /site_type="other"
                     /note="proline-rich peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:269918"
     Region          <302..522
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          600..626
                     /region_name="WH2_hVASP-like"
                     /note="Wiskott-Aldrich syndrome protein (WASP)-homology
                     domain 2 (WH2) of human Vasodilator-stimulated
                     phosphoprotein and related proteins; cd22185"
                     /db_xref="CDD:409225"
     Site            order(607..608,610..611,614,616..620)
                     /site_type="other"
                     /note="actin-binding motif [polypeptide binding]"
                     /db_xref="CDD:409225"
     Region          616..619
                     /region_name="actin-binding sequence"
                     /note="actin-binding sequence [structural motif]"
                     /db_xref="CDD:409225"
     Region          746..781
                     /region_name="VASP_tetra"
                     /note="VASP tetramerisation domain; pfam08776"
                     /db_xref="CDD:430211"
     CDS             1..785
                     /gene="Enah"
                     /gene_synonym="Mena; NDPP-1; Ndpp1; WBP8"
                     /coded_by="NM_001083120.3:449..2806"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS48473.1"
                     /db_xref="GeneID:13800"
                     /db_xref="MGI:MGI:108360"
ORIGIN      
        1 mseqsicqar aavmvyddan kkwvpaggst gfsrvhiyhh tgnntfrvvg rkiqdhqvvi
       61 ncaipkglky nqatqtfhqw rdarqvygln fgskedanvf asammhalev lnsqeagptl
      121 prqnsqlpaq vqngpsqeel eiqrrqlqeq qrqkelerer mererlerer lererlerer
      181 leqeqlerqr qerehverle rerlerlere rqerererle qlereqvewe rerrmsnaap
      241 ssdsslssap lpeysscqpp sapppsyakv isapvsdatp dyavvtalpp tstpptpplr
      301 haatrfatsl gsafhpvlph yatvprplnk nsrpsspvnt pssqppaaks cawptsnfsp
      361 lppsppimis sppgkatgpr pvlpvcvssp vpqmppspta pngsldsvty pvsppptsgp
      421 aapppppppp pppppppppl pppplpplas lshcgsqasp ppgtplastp sskpsvlpsp
      481 saaapasaet plnpelgdss asepglqaas qpaesptpqg lvlgppappp ppplpsgpay
      541 asalppppgp ppppplpstg pppppppppp lpnqappppp pppapplpas gifsgstsed
      601 nrpltglaaa iagaklrkvs rvedgsfpgg gntgsvslas skadagrgng plplggsglm
      661 eemsallarr rriaekgsti eteqkedrne daepitakap ststpeptrk pwertntmng
      721 skspvisrpk stpssqpsan gvqtegldyd rlkqdildem rkelaklkee lidairqels
      781 ksnta
//
LOCUS       NP_001345853             735 aa            linear   ROD 09-OCT-2023
DEFINITION  transcriptional repressor CTCF isoform 2 [Mus musculus].
ACCESSION   NP_001345853 XP_017168046
VERSION     NP_001345853.1
DBSOURCE    REFSEQ: accession NM_001358924.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 735)
  AUTHORS   Hewitt SC, Gruzdev A, Willson CJ, Wu SP, Lydon JP, Galjart N and
            DeMayo FJ.
  TITLE     Chromatin architectural factor CTCF is essential for
            progesterone-dependent uterine maturation
  JOURNAL   FASEB J 37 (8), e23103 (2023)
   PUBMED   37489832
  REMARK    GeneRIF: Chromatin architectural factor CTCF is essential for
            progesterone-dependent uterine maturation.
REFERENCE   2  (residues 1 to 735)
  AUTHORS   Smits WK, Vermeulen C, Hagelaar R, Kimura S, Vroegindeweij EM,
            Buijs-Gladdines JGCAM, van de Geer E, Verstegen MJAM, Splinter E,
            van Reijmersdal SV, Buijs A, Galjart N, van Eyndhoven W, van Min M,
            Kuiper R, Kemmeren P, Mullighan CG, de Laat W and Meijerink JPP.
  TITLE     Elevated enhancer-oncogene contacts and higher oncogene expression
            levels by recurrent CTCF inactivating mutations in acute T cell
            leukemia
  JOURNAL   Cell Rep 42 (4), 112373 (2023)
   PUBMED   37060567
REFERENCE   3  (residues 1 to 735)
  AUTHORS   Wang B, Ji L and Bian Q.
  TITLE     SATB1 regulates 3D genome architecture in T cells by constraining
            chromatin interactions surrounding CTCF-binding sites
  JOURNAL   Cell Rep 42 (4), 112323 (2023)
   PUBMED   37000624
  REMARK    GeneRIF: SATB1 regulates 3D genome architecture in T cells by
            constraining chromatin interactions surrounding CTCF-binding sites.
REFERENCE   4  (residues 1 to 735)
  AUTHORS   Marina-Zarate E, Rodriguez-Ronchel A, Gomez MJ, Sanchez-Cabo F and
            Ramiro AR.
  TITLE     Low-affinity CTCF binding drives transcriptional regulation whereas
            high-affinity binding encompasses architectural functions
  JOURNAL   iScience 26 (3), 106106 (2023)
   PUBMED   36852270
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 735)
  AUTHORS   Hsieh TS, Cattoglio C, Slobodyanyuk E, Hansen AS, Darzacq X and
            Tjian R.
  TITLE     Enhancer-promoter interactions and transcription are largely
            maintained upon acute loss of CTCF, cohesin, WAPL or YY1
  JOURNAL   Nat Genet 54 (12), 1919-1932 (2022)
   PUBMED   36471071
  REMARK    GeneRIF: Enhancer-promoter interactions and transcription are
            largely maintained upon acute loss of CTCF, cohesin, WAPL or YY1.
REFERENCE   6  (residues 1 to 735)
  AUTHORS   Farrell CM, West AG and Felsenfeld G.
  TITLE     Conserved CTCF insulator elements flank the mouse and human
            beta-globin loci
  JOURNAL   Mol Cell Biol 22 (11), 3820-3831 (2002)
   PUBMED   11997516
  REMARK    GeneRIF: Conserved CTCF insulator elements flank the mouse and
            human beta-globin loci.
REFERENCE   7  (residues 1 to 735)
  AUTHORS   Burke LJ, Hollemann T, Pieler T and Renkawitz R.
  TITLE     Molecular cloning and expression of the chromatin insulator protein
            CTCF in Xenopus laevis
  JOURNAL   Mech Dev 113 (1), 95-98 (2002)
   PUBMED   11900981
REFERENCE   8  (residues 1 to 735)
  AUTHORS   Chao W, Huynh KD, Spencer RJ, Davidow LS and Lee JT.
  TITLE     CTCF, a candidate trans-acting factor for X-inactivation choice
  JOURNAL   Science 295 (5553), 345-347 (2002)
   PUBMED   11743158
  REMARK    GeneRIF: It's proposed that Tsix and CTCF together establish a
            regulatable epigenetic switch for X-inactivation.
REFERENCE   9  (residues 1 to 735)
  AUTHORS   Lutz M, Burke LJ, Barreto G, Goeman F, Greb H, Arnold R,
            Schultheiss H, Brehm A, Kouzarides T, Lobanenkov V and Renkawitz R.
  TITLE     Transcriptional repression by the insulator protein CTCF involves
            histone deacetylases
  JOURNAL   Nucleic Acids Res 28 (8), 1707-1713 (2000)
   PUBMED   10734189
REFERENCE   10 (residues 1 to 735)
  AUTHORS   Filippova GN, Fagerlie S, Klenova EM, Myers C, Dehner Y, Goodwin G,
            Neiman PE, Collins SJ and Lobanenkov VV.
  TITLE     An exceptionally conserved transcriptional repressor, CTCF, employs
            different combinations of zinc fingers to bind diverged promoter
            sequences of avian and mammalian c-myc oncogenes
  JOURNAL   Mol Cell Biol 16 (6), 2802-2813 (1996)
   PUBMED   8649389
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127419.3 and AC152826.2.
            
            On Dec 13, 2017 this sequence version replaced XP_017168046.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13948564.1288730.1,
                                           SRR14777531.548209.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..735
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.04 cM"
     Protein         1..735
                     /product="transcriptional repressor CTCF isoform 2"
                     /note="transcriptional repressor CTCF; CTCFL paralog;
                     11-zinc finger protein"
                     /calculated_mol_wt=83486
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          180..211
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61164.2)"
     Region          266..289
                     /region_name="zf-H2C2_5"
                     /note="C2H2-type zinc-finger domain; pfam13909"
                     /db_xref="CDD:404746"
     Region          268..288
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(268,271,284,288)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:275368"
     Site            order(273,275,277,279..280,283..284,287,301,303,307..308,
                     311..312,315,329,331,333,335..336,339..340,346)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          280..305
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:433230"
     Site            289
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          296..316
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          309..333
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:433230"
     Site            317
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          324..347
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          351..375
                     /region_name="zf-H2C2_5"
                     /note="C2H2-type zinc-finger domain; pfam13909"
                     /db_xref="CDD:404746"
     Region          353..373
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          <366..500
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Site            374
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          381..401
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            402
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          409..426
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          439..457
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          469..489
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(469,472,485,489)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:275368"
     Site            order(474,476,478,480..481,484..485,488,502,504,508..509,
                     512..513,516,530,532,534,536..537,540..541,545)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          497..517
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          509..534
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:433230"
     Region          525..546
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          557..573
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            609
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Site            610
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Site            612
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          698..725
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61164.2)"
     CDS             1..735
                     /gene="Ctcf"
                     /coded_by="NM_001358924.2:327..2534"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="GeneID:13018"
                     /db_xref="MGI:MGI:109447"
ORIGIN      
        1 megeaveaiv eesetfikgk erktyqrrre ggqeedachl pqnqtdggev vqdvnssvqm
       61 vmmeqldptl lqmktevmeg tvapeaeaav ddtqiitlqv vnmeeqpini gelqlvqvpv
      121 pvtvpvatts veelqgayen evskeglaes epmichtlpl pegfqvvkvg angevetleq
      181 gelppqedss wqkdpdyqpp akktkktkks klryteegkd vdvsvydfee eqqegllsev
      241 naekvvgnmk ppkptkikkk gvkktfqcel csytcprrsn ldrhmkshtd erphkchlcg
      301 rafrtvtllr nhlnthtgtr phkcpdcdma fvtsgelvrh rrykhthekp fkcsmcdyas
      361 vevsklkrhi rshtgerpfq cslcsyasrd tyklkrhmrt hsgekpyecy icharftqsg
      421 tmkmhilqkh tenvakfhcp hcdtviarks dlgvhlrkqh syieqgkkcr ycdavfhery
      481 aliqhqkshk nekrfkcdqc dyacrqerhm imhkrthtge kpyacshcdk tfrqkqlldm
      541 hfkryhdpnf vpaafvcskc gktftrrntm arhadncagp dgvegengge tkkskrgrkr
      601 kmrskkedss dsenaepdld dneeeeepav eiepepepqp qpppppqpva papppakkrr
      661 grppgrtnqp kqnqptaiiq vedqntgaie niivevkkep daepaegeee eaqaattdap
      721 ngdltpemil smmdr
//
LOCUS       NP_032515                481 aa            linear   ROD 09-OCT-2023
DEFINITION  lipopolysaccharide-binding protein precursor [Mus musculus].
ACCESSION   NP_032515
VERSION     NP_032515.2
DBSOURCE    REFSEQ: accession NM_008489.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 481)
  AUTHORS   Xie L, Qiu S, Lu C, Gu C, Wang J, Lv J, Fang L, Chen Z, Li Y, Jiang
            T, Xia Y, Wang W, Li B and Xu Z.
  TITLE     Gastric cancer-derived LBP promotes liver metastasis by driving
            intrahepatic fibrotic pre-metastatic niche formation
  JOURNAL   J Exp Clin Cancer Res 42 (1), 258 (2023)
   PUBMED   37789385
  REMARK    GeneRIF: Gastric cancer-derived LBP promotes liver metastasis by
            driving intrahepatic fibrotic pre-metastatic niche formation.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 481)
  AUTHORS   Yin X, Xu Z, Zhang X, Wu J and Lu W.
  TITLE     Deficiency of lipopolysaccharide binding protein facilitates
            adipose browning, glucose uptake and oxygen consumption in mouse
            embryonic fibroblasts via activating PI3K/Akt/mTOR pathway and
            inhibiting autophagy
  JOURNAL   Cell Cycle 22 (8), 967-985 (2023)
   PUBMED   36710409
  REMARK    GeneRIF: Deficiency of lipopolysaccharide binding protein
            facilitates adipose browning, glucose uptake and oxygen consumption
            in mouse embryonic fibroblasts via activating PI3K/Akt/mTOR pathway
            and inhibiting autophagy.
REFERENCE   3  (residues 1 to 481)
  AUTHORS   Milbank E, Diaz-Trelles R, Dragano N, Latorre J, Mukthavaram R,
            Mayneris-Perxachs J, Ortega F, Federici M, Burcelin R, Karmali PP,
            Tachikawa K, Chivukula P, Lopez M, Fernandez-Real JM and
            Moreno-Navarrete JM.
  TITLE     Liver lipopolysaccharide binding protein prevents hepatic
            inflammation in physiological and pathological non-obesogenic
            conditions
  JOURNAL   Pharmacol Res 187, 106562 (2023)
   PUBMED   36410673
  REMARK    GeneRIF: Liver lipopolysaccharide binding protein prevents hepatic
            inflammation in physiological and pathological non-obesogenic
            conditions.
REFERENCE   4  (residues 1 to 481)
  AUTHORS   Jin CJ, Baumann A, Brandt A, Engstler AJ, Nier A, Hege M, Schmeer
            C, Kehm R, Hohn A, Grune T, Witte OW and Bergheim I.
  TITLE     Aging-related liver degeneration is associated with increased
            bacterial endotoxin and lipopolysaccharide binding protein levels
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 318 (4), G736-G747 (2020)
   PUBMED   32090603
REFERENCE   5  (residues 1 to 481)
  AUTHORS   Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK,
            Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L,
            Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre
            JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A,
            Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ,
            Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall
            S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA,
            Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR,
            Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana
            S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, MacArthur DG,
            Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC,
            Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL,
            de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown
            SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bucan M and Murray
            SA.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. PMID: 29144450]
REFERENCE   6  (residues 1 to 481)
  AUTHORS   Lengacher S, Reed D, Heumann D and Jongeneel CV.
  TITLE     Genomic organization and chromosomal localization of the mouse
            lipopolysaccharide binding protein gene
  JOURNAL   Immunogenetics 49 (6), 553-556 (1999)
   PUBMED   10380702
REFERENCE   7  (residues 1 to 481)
  AUTHORS   Ulevitch RJ and Tobias PS.
  TITLE     Recognition of gram-negative bacteria and endotoxin by the innate
            immune system
  JOURNAL   Curr Opin Immunol 11 (1), 19-22 (1999)
   PUBMED   10047547
  REMARK    Review article
REFERENCE   8  (residues 1 to 481)
  AUTHORS   Wurfel MM, Monks BG, Ingalls RR, Dedrick RL, Delude R, Zhou D,
            Lamping N, Schumann RR, Thieringer R, Fenton MJ, Wright SD and
            Golenbock D.
  TITLE     Targeted deletion of the lipopolysaccharide (LPS)-binding protein
            gene leads to profound suppression of LPS responses ex vivo,
            whereas in vivo responses remain intact
  JOURNAL   J Exp Med 186 (12), 2051-2056 (1997)
   PUBMED   9396775
REFERENCE   9  (residues 1 to 481)
  AUTHORS   Jack RS, Fan X, Bernheiden M, Rune G, Ehlers M, Weber A, Kirsch G,
            Mentel R, Furll B, Freudenberg M, Schmitz G, Stelter F and Schutt
            C.
  TITLE     Lipopolysaccharide-binding protein is required to combat a murine
            gram-negative bacterial infection
  JOURNAL   Nature 389 (6652), 742-745 (1997)
   PUBMED   9338787
REFERENCE   10 (residues 1 to 481)
  AUTHORS   Lengacher S, Jongeneel CV, Le Roy D, Lee JD, Kravchenko V, Ulevitch
            RJ, Glauser MP and Heumann D.
  TITLE     Reactivity of murine and human recombinant LPS-binding protein
            (LBP) within LPS and gram negative bacteria
  JOURNAL   J Inflamm 47 (4), 165-172 (1995)
   PUBMED   9144073
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK143562.1, AA207419.1, BQ176753.1, AL663063.14 and AI643881.1.
            
            On Sep 1, 2006 this sequence version replaced NP_032515.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X99347.1, BC004795.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 78.72 cM"
     Protein         1..481
                     /product="lipopolysaccharide-binding protein precursor"
                     /calculated_mol_wt=50628
     sig_peptide     1..25
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=2446
     Region          29..252
                     /region_name="BPI1"
                     /note="BPI/LBP/CETP N-terminal domain; Bactericidal
                     permeability-increasing protein (BPI) /
                     Lipopolysaccharide-binding protein (LBP) / Cholesteryl
                     ester transfer protein (CETP) N-terminal domain; binds to
                     and neutralizes lipopolysaccharides from the outer...;
                     cd00025"
                     /db_xref="CDD:237992"
     Site            29..35
                     /site_type="other"
                     /note="BPI dimerizatation interface [polypeptide binding]"
                     /db_xref="CDD:237992"
     Site            order(34,39,42,46,49,101,142,144,154,201,205,209,243)
                     /site_type="active"
                     /note="apolar binding pocket [active]"
                     /db_xref="CDD:237992"
     Region          241..478
                     /region_name="LBP_BPI_CETP_C"
                     /note="LBP / BPI / CETP family, C-terminal domain;
                     pfam02886"
                     /db_xref="CDD:397154"
     Site            order(277..281,461..466,472..477)
                     /site_type="other"
                     /note="BPI dimerization interface [polypeptide binding]"
                     /db_xref="CDD:237993"
     Site            order(281,286,289,293,296,356,389,391,400,436,440,444,448,
                     470)
                     /site_type="active"
                     /note="apolar binding pocket [active]"
                     /db_xref="CDD:237993"
     Site            300
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61805.2)"
     Site            355
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61805.2)"
     CDS             1..481
                     /gene="Lbp"
                     /gene_synonym="Bpifd2; Ly88"
                     /coded_by="NM_008489.2:178..1623"
                     /db_xref="CCDS:CCDS16988.1"
                     /db_xref="GeneID:16803"
                     /db_xref="MGI:MGI:1098776"
ORIGIN      
        1 mkagtgplls tllgllflsi qgtggvnpgv varitdkgla yaakeglval qrelykitlp
       61 dfsgdfkika vgrgqyefhs leiqncelrg sslkllpgqg lslaisdssi gvrgkwkvrk
      121 sflklhgsfd ldvkgvtisv dlllgmdpsg rptvsasgcs sricdldvhi sgnvgwllnl
      181 fhnqiesklq kvlenkvcem iqksvtsdlq pylqtlpvta eidnvlgidy slvaapqaka
      241 qvldvmfkge ifnrnhrspv atptptmslp edskqmvyfa isdyafnias rvyhqagyln
      301 fsitddmlph dsgirlntka frpftpqiyk kypdmklell gtvvsapiln vspgnlslap
      361 qmeiegfvil ptsarepvfr lgvvtnvfas ltfnnskvtg mlhpdkaqvr lieskvgmfn
      421 vnlfqaflny yllnslypdv naelaqgfpl plprhiqlhd ldfqirkdfl ylganvqymr
      481 v
//
LOCUS       NP_001076590             541 aa            linear   ROD 09-OCT-2023
DEFINITION  protein enabled homolog isoform 4 [Mus musculus].
ACCESSION   NP_001076590
VERSION     NP_001076590.1
DBSOURCE    REFSEQ: accession NM_001083121.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 541)
  AUTHORS   Yun S, Cha SS and Kim JH.
  TITLE     DJ-1 promotes cell migration by interacting with Mena, the
            mammalian homolog of Drosophila enabled
  JOURNAL   Adv Biol Regul 88, 100943 (2023)
   PUBMED   36542983
  REMARK    GeneRIF: DJ-1 promotes cell migration by interacting with Mena, the
            mammalian homolog of Drosophila enabled.
REFERENCE   2  (residues 1 to 541)
  AUTHORS   Wang W, Taufalele PV, Millet M, Homsy K, Smart K, Berestesky ED,
            Schunk CT, Rowe MM, Bordeleau F and Reinhart-King CA.
  TITLE     Matrix stiffness regulates tumor cell intravasation through
            expression and ESRP1-mediated alternative splicing of MENA
  JOURNAL   Cell Rep 42 (4), 112338 (2023)
   PUBMED   37027295
  REMARK    GeneRIF: Matrix stiffness regulates tumor cell intravasation
            through expression and ESRP1-mediated alternative splicing of MENA.
REFERENCE   3  (residues 1 to 541)
  AUTHORS   Borriello L, Coste A, Traub B, Sharma VP, Karagiannis GS, Lin Y,
            Wang Y, Ye X, Duran CL, Chen X, Friedman M, Sosa MS, Sun D, Dalla
            E, Singh DK, Oktay MH, Aguirre-Ghiso JA, Condeelis JS and Entenberg
            D.
  TITLE     Primary tumor associated macrophages activate programs of invasion
            and dormancy in disseminating tumor cells
  JOURNAL   Nat Commun 13 (1), 626 (2022)
   PUBMED   35110548
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 541)
  AUTHORS   Hooper JE, Jones KL, Smith FJ, Williams T and Li H.
  TITLE     An Alternative Splicing Program for Mouse Craniofacial Development
  JOURNAL   Front Physiol 11, 1099 (2020)
   PUBMED   33013468
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 541)
  AUTHORS   Lee S, Sears MJ, Zhang Z, Li H, Salhab I, Krebs P, Xing Y, Nah HD,
            Williams T and Carstens RP.
  TITLE     Cleft lip and cleft palate in Esrp1 knockout mice is associated
            with alterations in epithelial-mesenchymal crosstalk
  JOURNAL   Development 147 (21) (2020)
   PUBMED   32253237
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 541)
  AUTHORS   Ermekova KS, Zambrano N, Linn H, Minopoli G, Gertler F, Russo T and
            Sudol M.
  TITLE     The WW domain of neural protein FE65 interacts with proline-rich
            motifs in Mena, the mammalian homolog of Drosophila enabled
  JOURNAL   J Biol Chem 272 (52), 32869-32877 (1997)
   PUBMED   9407065
REFERENCE   7  (residues 1 to 541)
  AUTHORS   Bedford MT, Chan DC and Leder P.
  TITLE     FBP WW domains and the Abl SH3 domain bind to a specific class of
            proline-rich ligands
  JOURNAL   EMBO J 16 (9), 2376-2383 (1997)
   PUBMED   9171351
REFERENCE   8  (residues 1 to 541)
  AUTHORS   Yamabhai M and Kay BK.
  TITLE     Examining the specificity of Src homology 3 domain--ligand
            interactions with alkaline phosphatase fusion proteins
  JOURNAL   Anal Biochem 247 (1), 143-151 (1997)
   PUBMED   9126384
REFERENCE   9  (residues 1 to 541)
  AUTHORS   Gertler FB, Niebuhr K, Reinhard M, Wehland J and Soriano P.
  TITLE     Mena, a relative of VASP and Drosophila Enabled, is implicated in
            the control of microfilament dynamics
  JOURNAL   Cell 87 (2), 227-239 (1996)
   PUBMED   8861907
REFERENCE   10 (residues 1 to 541)
  AUTHORS   Sazuka T, Tomooka Y, Kathju S, Ikawa Y, Noda M and Kumar S.
  TITLE     Identification of a developmentally regulated gene in the mouse
            central nervous system which encodes a novel proline rich protein
  JOURNAL   Biochim Biophys Acta 1132 (3), 240-248 (1992)
   PUBMED   1420303
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122204.3 and AC165229.7.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U72520.1, SRR14777535.2956229.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..541
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 84.93 cM"
     Protein         1..541
                     /product="protein enabled homolog isoform 4"
                     /note="protein enabled homolog; NPC derived proline rich
                     protein 1"
                     /calculated_mol_wt=59512
     Region          5..112
                     /region_name="EVH1_Ena_VASP-like"
                     /note="Enabled/VASP family EVH1 domain; cd01207"
                     /db_xref="CDD:269918"
     Site            order(16,23,69,71,77,79,81)
                     /site_type="other"
                     /note="proline-rich peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:269918"
     Region          356..382
                     /region_name="WH2_hVASP-like"
                     /note="Wiskott-Aldrich syndrome protein (WASP)-homology
                     domain 2 (WH2) of human Vasodilator-stimulated
                     phosphoprotein and related proteins; cd22185"
                     /db_xref="CDD:409225"
     Site            order(363..364,366..367,370,372..376)
                     /site_type="other"
                     /note="actin-binding motif [polypeptide binding]"
                     /db_xref="CDD:409225"
     Region          372..375
                     /region_name="actin-binding sequence"
                     /note="actin-binding sequence [structural motif]"
                     /db_xref="CDD:409225"
     Region          502..537
                     /region_name="VASP_tetra"
                     /note="VASP tetramerisation domain; pfam08776"
                     /db_xref="CDD:430211"
     CDS             1..541
                     /gene="Enah"
                     /gene_synonym="Mena; NDPP-1; Ndpp1; WBP8"
                     /coded_by="NM_001083121.3:449..2074"
                     /note="isoform 4 is encoded by transcript variant 4"
                     /db_xref="CCDS:CCDS78764.1"
                     /db_xref="GeneID:13800"
                     /db_xref="MGI:MGI:108360"
ORIGIN      
        1 mseqsicqar aavmvyddan kkwvpaggst gfsrvhiyhh tgnntfrvvg rkiqdhqvvi
       61 ncaipkglky nqatqtfhqw rdarqvygln fgskedanvf asammhalev lnsqeagptl
      121 prqnsqlpaq vqngpsqeel eiqrrqlqeq qrqkelerer mererlerer lererlerer
      181 leqeqlerqr qerehverle rerlerlere rqerererle qlereqvewe rerrmsnaaa
      241 pasaetplnp elgdssasep glqaasqpae sptpqglvlg ppappppppl psgpayasal
      301 ppppgppppp plpstgpppp pppppplpnq appppppppa pplpasgifs gstsednrpl
      361 tglaaaiaga klrkvsrved gsfpgggntg svslasskad agrgngplpl ggsglmeems
      421 allarrrria ekgstieteq kedrnedaep itakapstst peptrkpwer tntmngsksp
      481 visrpkstps sqpsangvqt egldydrlkq dildemrkel aklkeelida irqelsksnt
      541 a
//
LOCUS       NP_032939                521 aa            linear   ROD 09-OCT-2023
DEFINITION  protein phosphatase 3 catalytic subunit alpha isoform 1 [Mus
            musculus].
ACCESSION   NP_032939 XP_131226
VERSION     NP_032939.1
DBSOURCE    REFSEQ: accession NM_008913.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 521)
  AUTHORS   Wan X, Zhao S, Dai Y, Zhang J, Shen Y, Gong L and Le Q.
  TITLE     WNT16b promotes the proliferation and self-renewal of human limbal
            epithelial stem/progenitor cells via activating the
            calcium/calcineurin A/NFATC2 pathway
  JOURNAL   Cell Prolif 56 (10), e13460 (2023)
   PUBMED   36974338
  REMARK    GeneRIF: WNT16b promotes the proliferation and self-renewal of
            human limbal epithelial stem/progenitor cells via activating the
            calcium/calcineurin A/NFATC2 pathway.
REFERENCE   2  (residues 1 to 521)
  AUTHORS   Delint-Ramirez I, Konada L, Heady L, Rueda R, Jacome ASV, Marlin E,
            Marchioni C, Segev A, Kritskiy O, Yamakawa S, Reiter AH, Tsai LH
            and Madabhushi R.
  TITLE     Calcineurin dephosphorylates topoisomerase IIbeta and regulates the
            formation of neuronal-activity-induced DNA breaks
  JOURNAL   Mol Cell 82 (20), 3794-3809 (2022)
   PUBMED   36206766
  REMARK    GeneRIF: Calcineurin dephosphorylates topoisomerase IIbeta and
            regulates the formation of neuronal-activity-induced DNA breaks.
REFERENCE   3  (residues 1 to 521)
  AUTHORS   Miura E and Watanabe M.
  TITLE     Coexpression of calcineurin A and B subunits in various subcellular
            and synaptic compartments of cerebellar neurons and glia with
            particular abundance at parallel fiber-Purkinje cell synapses
  JOURNAL   Neurosci Res 180, 13-22 (2022)
   PUBMED   35247520
  REMARK    GeneRIF: Coexpression of calcineurin A and B subunits in various
            subcellular and synaptic compartments of cerebellar neurons and
            glia with particular abundance at parallel fiber-Purkinje cell
            synapses.
REFERENCE   4  (residues 1 to 521)
  AUTHORS   Bedogni F and Hevner RF.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 521)
  AUTHORS   Sidoli M, Reed CB, Scapin C, Paez P, Cavener DR, Kaufman RJ,
            D'Antonio M, Feltri ML and Wrabetz L.
  TITLE     Calcineurin Activity Is Increased in Charcot-Marie-Tooth 1B
            Demyelinating Neuropathy
  JOURNAL   J Neurosci 41 (20), 4536-4548 (2021)
   PUBMED   33879538
REFERENCE   6  (residues 1 to 521)
  AUTHORS   Gaestel M, Benndorf R, Hayess K, Priemer E and Engel K.
  TITLE     Dephosphorylation of the small heat shock protein hsp25 by
            calcium/calmodulin-dependent (type 2B) protein phosphatase
  JOURNAL   J Biol Chem 267 (30), 21607-21611 (1992)
   PUBMED   1328240
REFERENCE   7  (residues 1 to 521)
  AUTHORS   Giri PR, Marietta CA, Higuchi S and Kincaid RL.
  TITLE     Molecular and phylogenetic analysis of calmodulin-dependent protein
            phosphatase (calcineurin) catalytic subunit genes
  JOURNAL   DNA Cell Biol 11 (5), 415-424 (1992)
   PUBMED   1318721
REFERENCE   8  (residues 1 to 521)
  AUTHORS   Kincaid RL, Giri PR, Higuchi S, Tamura J, Dixon SC, Marietta CA,
            Amorese DA and Martin BM.
  TITLE     Cloning and characterization of molecular isoforms of the catalytic
            subunit of calcineurin using nonisotopic methods
  JOURNAL   J Biol Chem 265 (19), 11312-11319 (1990)
   PUBMED   2162844
REFERENCE   9  (residues 1 to 521)
  AUTHORS   Guerini D and Klee CB.
  TITLE     Cloning of human calcineurin A: evidence for two isozymes and
            identification of a polyproline structural domain
  JOURNAL   Proc Natl Acad Sci U S A 86 (23), 9183-9187 (1989)
   PUBMED   2556704
REFERENCE   10 (residues 1 to 521)
  AUTHORS   Kincaid RL, Nightingale MS and Martin BM.
  TITLE     Characterization of a cDNA clone encoding the calmodulin-binding
            domain of mouse brain calcineurin
  JOURNAL   Proc Natl Acad Sci U S A 85 (23), 8983-8987 (1988)
   PUBMED   2848250
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116384.9, AC124177.2, AC129775.4 and AI835974.1.
            
            On Feb 9, 2004 this sequence version replaced XP_131226.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J05479.1, BC138612.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..521
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 63.34 cM"
     Protein         1..521
                     /product="protein phosphatase 3 catalytic subunit alpha
                     isoform 1"
                     /EC_number="3.1.3.16"
                     /note="calcineurin A alpha; protein phosphatase 3
                     catalytic subunit alpha; CAM-PRP catalytic subunit; PP2BA
                     alpha; PP2B alpha 1; CNA alpha"
                     /calculated_mol_wt=58513
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylserine.
                     /evidence=ECO:0000250|UniProtKB:Q08209; propagated from
                     UniProtKB/Swiss-Prot (P63328.1)"
     Region          41..345
                     /region_name="MPP_PP2B"
                     /note="PP2B, metallophosphatase domain; cd07416"
                     /db_xref="CDD:277361"
     Site            order(53,55,90,92,118,150,159,199,281,314,341)
                     /site_type="other"
                     /note="CN-CyPA-CsA complex [polypeptide binding]"
                     /db_xref="CDD:277361"
     Region          56..340
                     /region_name="Catalytic. /evidence=ECO:0000305"
                     /note="propagated from UniProtKB/Swiss-Prot (P63328.1)"
     Site            order(90,92,118,122,150..151,199,232,254,281,283)
                     /site_type="active"
                     /db_xref="CDD:277361"
     Site            order(90,92,118,150,199,281)
                     /site_type="metal-binding"
                     /note="metal binding site [ion binding]"
                     /db_xref="CDD:277361"
     Region          307..311
                     /region_name="SAPNY motif.
                     /evidence=ECO:0000250|UniProtKB:Q08209"
                     /note="propagated from UniProtKB/Swiss-Prot (P63328.1)"
     Region          327..336
                     /region_name="Interaction with PxIxIF motif in substrate.
                     /evidence=ECO:0000250|UniProtKB:Q08209"
                     /note="propagated from UniProtKB/Swiss-Prot (P63328.1)"
     Region          341..369
                     /region_name="Calcineurin B binding.
                     /evidence=ECO:0000269|PubMed:26794871"
                     /note="propagated from UniProtKB/Swiss-Prot (P63328.1)"
     Site            352
                     /site_type="other"
                     /note="Interaction with PxVP motif in substrate.
                     /evidence=ECO:0000250|UniProtKB:Q08209; propagated from
                     UniProtKB/Swiss-Prot (P63328.1)"
     Region          392..406
                     /region_name="Calmodulin-binding.
                     /evidence=ECO:0000269|PubMed:26794871"
                     /note="propagated from UniProtKB/Swiss-Prot (P63328.1)"
     Region          407..414
                     /region_name="Autoinhibitory segment.
                     /evidence=ECO:0000269|PubMed:26794871"
                     /note="propagated from UniProtKB/Swiss-Prot (P63328.1)"
     Region          465..487
                     /region_name="Autoinhibitory domain.
                     /evidence=ECO:0000269|PubMed:26794871"
                     /note="propagated from UniProtKB/Swiss-Prot (P63328.1)"
     Site            469
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P63329; propagated from
                     UniProtKB/Swiss-Prot (P63328.1)"
     Region          475..521
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P63328.1)"
     Site            492
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P63328.1)"
     CDS             1..521
                     /gene="Ppp3ca"
                     /gene_synonym="2900074D19Rik; Caln; Calna; CN; CnA"
                     /coded_by="NM_008913.5:779..2344"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS17860.1"
                     /db_xref="GeneID:19055"
                     /db_xref="MGI:MGI:107164"
ORIGIN      
        1 msepkaidpk lsttdrvvka vpfppshrlt akevfdndgk prvdilkahl mkegrleesv
       61 alriitegas ilrqeknlld idapvtvcgd ihgqffdlmk lfevggspan trylflgdyv
      121 drgyfsiecv lylwalkily pktlfllrgn hecrhlteyf tfkqeckiky servydacmd
      181 afdclplaal mnqqflcvhg glspeintld dirkldrfke ppaygpmcdi lwsdpledfg
      241 nektqehfth ntvrgcsyfy sypavcdflq hnnllsilra heaqdagyrm yrksqttgfp
      301 slitifsapn yldvynnkaa vlkyennvmn irqfncsphp ywlpnfmdvf twslpfvgek
      361 vtemlvnvln icsddelgse edgfdgataa arkevirnki raigkmarvf svlreesesv
      421 ltlkgltptg mlpsgvlsgg kqtlqsatve aieadeaikg fspqhkitsf eeakgldrin
      481 ermpprrdam psdanlnsin kalasetngt dsngsnssni q
//
LOCUS       NP_998825                769 aa            linear   ROD 09-OCT-2023
DEFINITION  signal transducer and activator of transcription 3 isoform 2 [Mus
            musculus].
ACCESSION   NP_998825 XP_001005155
VERSION     NP_998825.1
DBSOURCE    REFSEQ: accession NM_213660.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 769)
  AUTHORS   Xiao D, Zeng T, Zhu W, Yu ZZ, Huang W, Yi H, Lu SS, Feng J, Feng
            XP, Wu D, Wen Q, Zhou JH, Yuan L, Zhuang W and Xiao ZQ.
  TITLE     ANXA1 Promotes Tumor Immune Evasion by Binding PARP1 and
            Upregulating Stat3-Induced Expression of PD-L1 in Multiple Cancers
  JOURNAL   Cancer Immunol Res 11 (10), 1367-1383 (2023)
   PUBMED   37566399
  REMARK    GeneRIF: ANXA1 Promotes Tumor Immune Evasion by Binding PARP1 and
            Upregulating Stat3-Induced Expression of PD-L1 in Multiple Cancers.
REFERENCE   2  (residues 1 to 769)
  AUTHORS   Ramos RB, Martino N, Chuy D, Lu S, Zuo MXG, Balasubramanian U, Di
            John Portela I, Vincent PA and Adam AP.
  TITLE     Shock drives a STAT3 and JunB-mediated coordinated transcriptional
            and DNA methylation response in the endothelium
  JOURNAL   J Cell Sci 136 (18) (2023)
   PUBMED   37667913
  REMARK    GeneRIF: Shock drives a STAT3 and JunB-mediated coordinated
            transcriptional and DNA methylation response in the endothelium.
REFERENCE   3  (residues 1 to 769)
  AUTHORS   Liu L, Xu W, Li K, Hu Y, Shen L, Zhang H and Wang Y.
  TITLE     Kv1.3 mediates ox-LDL-induced vascular smooth muscle cell
            proliferation through JAK2/STAT3 signaling pathway
  JOURNAL   Arch Biochem Biophys 746, 109719 (2023)
   PUBMED   37591369
  REMARK    GeneRIF: Kv1.3 mediates ox-LDL-induced vascular smooth muscle cell
            proliferation through JAK2/STAT3 signaling pathway.
REFERENCE   4  (residues 1 to 769)
  AUTHORS   Xu F, Lu S, Jia X and Zhou Y.
  TITLE     Bromodomain protein 4 mediates the roles of TGFbeta1-induced Stat3
            signaling in mouse liver fibrogenesis
  JOURNAL   Toxicol Lett 385, 42-50 (2023)
   PUBMED   37634812
  REMARK    GeneRIF: Bromodomain protein 4 mediates the roles of
            TGFbeta1-induced Stat3 signaling in mouse liver fibrogenesis.
REFERENCE   5  (residues 1 to 769)
  AUTHORS   Pencik J, Philippe C, Schlederer M, Atas E, Pecoraro M,
            Grund-Groschke S, Li WJ, Tracz A, Heidegger I, Lagger S, Trachtova
            K, Oberhuber M, Heitzer E, Aksoy O, Neubauer HA, Wingelhofer B,
            Orlova A, Witzeneder N, Dillinger T, Redl E, Greiner G, D'Andrea D,
            Ostman JR, Tangermann S, Hermanova I, Schafer G, Sternberg F, Pohl
            EE, Sternberg C, Varady A, Horvath J, Stoiber D, Malcolm TI, Turner
            SD, Parkes EE, Hantusch B, Egger G, Rose-John S, Poli V, Jain S,
            Armstrong CWD, Hoermann G, Goffin V, Aberger F, Moriggl R,
            Carracedo A, McKinney C, Kennedy RD, Klocker H, Speicher MR, Tang
            DG, Moazzami AA, Heery DM, Hacker M and Kenner L.
  TITLE     STAT3/LKB1 controls metastatic prostate cancer by regulating
            mTORC1/CREB pathway
  JOURNAL   Mol Cancer 22 (1), 133 (2023)
   PUBMED   37573301
  REMARK    GeneRIF: STAT3/LKB1 controls metastatic prostate cancer by
            regulating mTORC1/CREB pathway.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 769)
  AUTHORS   Schaefer TS, Sanders LK and Nathans D.
  TITLE     Cooperative transcriptional activity of Jun and Stat3 beta, a short
            form of Stat3
  JOURNAL   Proc Natl Acad Sci U S A 92 (20), 9097-9101 (1995)
   PUBMED   7568080
REFERENCE   7  (residues 1 to 769)
  AUTHORS   Wen Z, Zhong Z and Darnell JE Jr.
  TITLE     Maximal activation of transcription by Stat1 and Stat3 requires
            both tyrosine and serine phosphorylation
  JOURNAL   Cell 82 (2), 241-250 (1995)
   PUBMED   7543024
REFERENCE   8  (residues 1 to 769)
  AUTHORS   Raz R, Durbin JE and Levy DE.
  TITLE     Acute phase response factor and additional members of the
            interferon-stimulated gene factor 3 family integrate diverse
            signals from cytokines, interferons, and growth factors
  JOURNAL   J Biol Chem 269 (39), 24391-24395 (1994)
   PUBMED   7523373
REFERENCE   9  (residues 1 to 769)
  AUTHORS   Zhong Z, Wen Z and Darnell JE Jr.
  TITLE     Stat3 and Stat4: members of the family of signal transducers and
            activators of transcription
  JOURNAL   Proc Natl Acad Sci U S A 91 (11), 4806-4810 (1994)
   PUBMED   7545930
REFERENCE   10 (residues 1 to 769)
  AUTHORS   Akira S, Nishio Y, Inoue M, Wang XJ, Wei S, Matsusaka T, Yoshida K,
            Sudo T, Naruto M and Kishimoto T.
  TITLE     Molecular cloning of APRF, a novel IFN-stimulated gene factor 3
            p91-related transcription factor involved in the gp130-mediated
            signaling pathway
  JOURNAL   Cell 77 (1), 63-71 (1994)
   PUBMED   7512451
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL591466.8.
            
            On Aug 25, 2006 this sequence version replaced XP_001005155.1.
            
            Summary: The protein encoded by this gene is a member of the STAT
            protein family. In response to cytokines and growth factors, STAT
            family members are phosphorylated by the receptor associated
            kinases, and then form homo- or heterodimers that translocate to
            the cell nucleus where they act as transcription activators. This
            protein is activated through phosphorylation in response to various
            cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF,
            LIF and BMP2. This protein mediates the expression of a variety of
            genes in response to cell stimuli, and thus plays a key role in
            many cellular processes such as cell growth and apoptosis. The
            small GTPase Rac1 has been shown to bind and regulate the activity
            of this protein. PIAS3 protein is a specific inhibitor of this
            protein. Alternative splicing results in multiple transcript
            variants encoding distinct isoforms. [provided by RefSeq, Sep
            2015].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 3' coding region, compared to variant 1. The
            encoded isoform (2) is shorter than isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U08378.1, SRR1660815.12556.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..769
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 63.82 cM"
     Protein         1..769
                     /product="signal transducer and activator of transcription
                     3 isoform 2"
                     /note="acute phase response factor"
                     /calculated_mol_wt=87836
     Region          2..120
                     /region_name="STAT_int"
                     /note="STAT protein, protein interaction domain;
                     smart00964"
                     /db_xref="CDD:214942"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:P40763; propagated from
                     UniProtKB/Swiss-Prot (P42227.2)"
     Region          139..318
                     /region_name="STAT3_CCD"
                     /note="Coiled-coil domain of Signal Transducer and
                     Activator of Transcription 3 (STAT3); cd16853"
                     /db_xref="CDD:341078"
     Site            order(142..165,213..239,263..284)
                     /site_type="other"
                     /note="coiled-coil motif"
                     /db_xref="CDD:341078"
     Region          150..162
                     /region_name="Essential for nuclear import"
                     /note="propagated from UniProtKB/Swiss-Prot (P42227.2)"
     Site            214..215
                     /site_type="other"
                     /note="ligand inducing"
                     /db_xref="CDD:341078"
     Site            order(243,245,247..248,251..252,260..261,264,267..268,
                     271..272,275,278..279,313..314)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:341078"
     Region          321..484
                     /region_name="STAT3_DBD"
                     /note="DNA-binding domain of Signal Transducer and
                     Activator of Transcription 3 (STAT3); cd16847"
                     /db_xref="CDD:341085"
     Site            order(382,417,432,465..466,469)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:341085"
     Region          554..714
                     /region_name="SH2_STAT3"
                     /note="Src homology 2 (SH2) domain found in signal
                     transducer and activator of transcription (STAT) 3
                     proteins; cd10374"
                     /db_xref="CDD:198237"
     Site            order(591,609,636,638)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198237"
     Site            601
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P40763; propagated from
                     UniProtKB/Swiss-Prot (P42227.2)"
     Site            615
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P40763; propagated from
                     UniProtKB/Swiss-Prot (P42227.2)"
     Site            631
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P40763; propagated from
                     UniProtKB/Swiss-Prot (P42227.2)"
     Site            order(637,653)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198237"
     Site            order(647..648,709)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:198237"
     Site            685
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P40763; propagated from
                     UniProtKB/Swiss-Prot (P42227.2)"
     Site            704
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by FER and PTK6.
                     /evidence=ECO:0000269|PubMed:11294897,
                     ECO:0000269|PubMed:11553624, ECO:0007744|PubMed:18034455;
                     propagated from UniProtKB/Swiss-Prot (P42227.2)"
     Site            706
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P40763; propagated from
                     UniProtKB/Swiss-Prot (P42227.2)"
     Site            713
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P42227.2)"
     Site            726
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by DYRK2, NLK, NEK6, IRAK1, RPS6KA5,
                     ZIPK/DAPK3 and PKC/PRKCE.
                     /evidence=ECO:0000305|PubMed:11553624,
                     ECO:0000305|PubMed:15004007, ECO:0000305|PubMed:20595392,
                     ECO:0000305|PubMed:7543024, ECO:0007744|PubMed:21183079;
                     propagated from UniProtKB/Swiss-Prot (P42227.2)"
     CDS             1..769
                     /gene="Stat3"
                     /gene_synonym="1110034C02Rik; Aprf"
                     /coded_by="NM_213660.3:309..2618"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS48934.1"
                     /db_xref="GeneID:20848"
                     /db_xref="MGI:MGI:103038"
ORIGIN      
        1 maqwnqlqql dtryleqlhq lysdsfpmel rqflapwies qdwayaaske shatlvfhnl
       61 lgeidqqysr flqesnvlyq hnlrrikqfl qsrylekpme iarivarclw eesrllqtaa
      121 taaqqggqan hptaavvtek qqmleqhlqd vrkrvqdleq kmkvvenlqd dfdfnyktlk
      181 sqgdmqdlng nnqsvtrqkm qqleqmltal dqmrrsivse lagllsamey vqktltdeel
      241 adwkrrqqia ciggppnicl drlenwitsl aesqlqtrqq ikkleelqqk vsykgdpivq
      301 hrpmleeriv elfrnlmksa fvverqpcmp mhpdrplvik tgvqfttkvr llvkfpelny
      361 qlkikvcidk dsgdvaalrg srkfnilgtn tkvmnmeesn ngslsaefkh ltlreqrcgn
      421 ggrancdasl ivteelhlit fetevyhqgl kidlethslp vvvisnicqm pnawasilwy
      481 nmltnnpknv nfftkppigt wdqvaevlsw qfssttkrgl sieqlttlae kllgpgvnys
      541 gcqitwakfc kenmagkgfs fwvwldniid lvkkyilalw negyimgfis kererailst
      601 kppgtfllrf sesskeggvt ftwvekdisg ktqiqsvepy tkqqlnnmsf aeiimgykim
      661 datnilvspl vylypdipke eafgkycrpe sqehpeadpg aapylktkfi cvtpttcsnt
      721 idlpmsprtl dslmqfgnng egaepsaggq fesltfdmdl tsecatspm
//
LOCUS       NP_001333981             604 aa            linear   ROD 09-OCT-2023
DEFINITION  epithelial splicing regulatory protein 1 isoform 3 [Mus musculus].
ACCESSION   NP_001333981 XP_006537783
VERSION     NP_001333981.1
DBSOURCE    REFSEQ: accession NM_001347052.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 604)
  AUTHORS   Wang W, Taufalele PV, Millet M, Homsy K, Smart K, Berestesky ED,
            Schunk CT, Rowe MM, Bordeleau F and Reinhart-King CA.
  TITLE     Matrix stiffness regulates tumor cell intravasation through
            expression and ESRP1-mediated alternative splicing of MENA
  JOURNAL   Cell Rep 42 (4), 112338 (2023)
   PUBMED   37027295
  REMARK    GeneRIF: Matrix stiffness regulates tumor cell intravasation
            through expression and ESRP1-mediated alternative splicing of MENA.
REFERENCE   2  (residues 1 to 604)
  AUTHORS   Zhao Y, Li M, Wu W, Miao W and Liu H.
  TITLE     Downregulated ESRP1/2 promotes lung metastasis of bladder carcinoma
            through altering FGFR2 splicing and macrophage polarization
  JOURNAL   Front Immunol 14, 1161273 (2023)
   PUBMED   37090731
  REMARK    GeneRIF: Downregulated ESRP1/2 promotes lung metastasis of bladder
            carcinoma through altering FGFR2 splicing and macrophage
            polarization.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 604)
  AUTHORS   Peart NJ, Hwang JY, Quesnel-Vallieres M, Sears MJ, Yang Y, Stoilov
            P, Barash Y, Park JW, Lynch KW and Carstens RP.
  TITLE     The global Protein-RNA interaction map of ESRP1 defines a
            post-transcriptional program that is essential for epithelial cell
            function
  JOURNAL   iScience 25 (10), 105205 (2022)
   PUBMED   36238894
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 604)
  AUTHORS   Spruce T, Plass M, Gohr A, Ray D, Martinez de Lagran M, Rot G,
            Novoa A, Burguera D, Permanyer J, Miret M, Zheng H, Swanson MS,
            Morris Q, Mallo M, Dierssen M, Hughes TR, Pernaute B and Irimia M.
  TITLE     The X-linked splicing regulator MBNL3 has been co-opted to restrict
            placental growth in eutherians
  JOURNAL   PLoS Biol 20 (4), e3001615 (2022)
   PUBMED   35476669
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 604)
  AUTHORS   Yu L, Zhang H, Guan X, Qin D, Zhou J and Wu X.
  TITLE     Loss of ESRP1 blocks mouse oocyte development and leads to female
            infertility
  JOURNAL   Development 148 (2) (2021)
   PUBMED   33318146
  REMARK    GeneRIF: Loss of ESRP1 blocks mouse oocyte development and leads to
            female infertility.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 604)
  AUTHORS   Warzecha CC, Sato TK, Nabet B, Hogenesch JB and Carstens RP.
  TITLE     ESRP1 and ESRP2 are epithelial cell-type-specific regulators of
            FGFR2 splicing
  JOURNAL   Mol Cell 33 (5), 591-601 (2009)
   PUBMED   19285943
  REMARK    GeneRIF: Epithelial splicing regulatory proteins 1/2 (ESRP1/2) are
            epithelial cell-type-specific regulators of FGFR2 splicing.
REFERENCE   7  (residues 1 to 604)
  AUTHORS   Sherwood RI, Jitianu C, Cleaver O, Shaywitz DA, Lamenzo JO, Chen
            AE, Golub TR and Melton DA.
  TITLE     Prospective isolation and global gene expression analysis of
            definitive and visceral endoderm
  JOURNAL   Dev Biol 304 (2), 541-555 (2007)
   PUBMED   17328885
REFERENCE   8  (residues 1 to 604)
  AUTHORS   Evsikov AV, Graber JH, Brockman JM, Hampl A, Holbrook AE, Singh P,
            Eppig JJ, Solter D and Knowles BB.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   9  (residues 1 to 604)
  AUTHORS   McKee AE, Minet E, Stern C, Riahi S, Stiles CD and Silver PA.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   10 (residues 1 to 604)
  AUTHORS   Piao Y, Ko NT, Lim MK and Ko MS.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL772170.14.
            
            On Nov 15, 2016 this sequence version replaced XP_006537783.1.
            
            Transcript Variant: This variant (3) uses an alternate in-frame
            splice junction in the 3' end and differs in the 3' UTR and coding
            sequence compared to variant 1. The resulting isoform (3) lacks an
            alternate internal segment and has a shorter and distinct
            C-terminus compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..604
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 5.11 cM"
     Protein         1..604
                     /product="epithelial splicing regulatory protein 1 isoform
                     3"
                     /note="RNA binding motif protein 35A"
                     /calculated_mol_wt=67127
     Region          29..>145
                     /region_name="DnaQ_like_exo"
                     /note="DnaQ-like (or DEDD) 3'-5' exonuclease domain
                     superfamily; cl10012"
                     /db_xref="CDD:447876"
     Region          216..308
                     /region_name="RRM_SF"
                     /note="RNA recognition motif (RRM) superfamily; cl17169"
                     /db_xref="CDD:450164"
     Region          310..419
                     /region_name="RRM2_ESRP1"
                     /note="RNA recognition motif 2 (RRM2) found in epithelial
                     splicing regulatory protein 1 (ESRP1) and similar
                     proteins; cd12739"
                     /db_xref="CDD:410136"
     Region          444..524
                     /region_name="RRM3_ESRP1_ESRP2"
                     /note="RNA recognition motif 3 (RRM3) found in epithelial
                     splicing regulatory protein ESRP1, ESRP2 and similar
                     proteins; cd12742"
                     /db_xref="CDD:410138"
     Site            543
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H6T0; propagated from
                     UniProtKB/Swiss-Prot (Q3US41.2)"
     Site            578
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:Q6NXG1; propagated from
                     UniProtKB/Swiss-Prot (Q3US41.2)"
     CDS             1..604
                     /gene="Esrp1"
                     /gene_synonym="2210008M09Rik; A630065D16; Rbm35a"
                     /coded_by="NM_001347052.1:343..2157"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS84703.1"
                     /db_xref="GeneID:207920"
                     /db_xref="MGI:MGI:1917326"
ORIGIN      
        1 mtaspdylvv lfgitagatg aklgsdekel illlwkvvdl ankkvgqlhe vlvrpdqlel
       61 tedckeetki daenlssapq ldqalrqfnq svsnelnigv gtsfclctdg qlhirqilhp
      121 easkknvllp ecfysffdlr kefkkccpgs pdidkldvaa mteslnfeks dsvsrygasq
      181 vedmgniila misepynhrf sdpervnykf esgtcskmel iddstvvrar glpwqssdqd
      241 iarffkglni akggaalcln aqgrrngeal vrfvseehrd lalqrhkhhm gtryievyka
      301 tgedflkiag gtsnevaqfl skenqvivrm rglpftatae evvaffgqhc pitggkegil
      361 fvtypdgrpt gdafvlface eyaqnalrkh kellgkryie lfrstaaevq qvlnrfssap
      421 liplptppii pvlpqqfvpp tnvrdcirlr glpyaatied ildflgefst dirthgvhmv
      481 lnhqgrpsgd afiqmkstdr afmaaqkyhk ktmkdryvev fqcsaeemnf vlmggtlnrn
      541 glspppclsp psytfpapta vipteaaiyq pslllnpral qpstayypag tqlfmnytay
      601 ypsv
//
LOCUS       NP_001397163             479 aa            linear   ROD 09-OCT-2023
DEFINITION  nuclear respiratory factor 1 isoform k [Mus musculus].
ACCESSION   NP_001397163 XP_030111079
VERSION     NP_001397163.1
DBSOURCE    REFSEQ: accession NM_001410234.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 479)
  AUTHORS   Cheng C, Tian Y, Yang R, Guo W, Xiao K, Zhang F, Tian J, Deng Z,
            Yang W, Yang H and Zhou Z.
  TITLE     miR-5581 Contributes to Osteoarthritis by Targeting NRF1 to Disturb
            the Proliferation and Functions of Chondrocytes
  JOURNAL   Am J Pathol 193 (9), 1234-1247 (2023)
   PUBMED   37611970
  REMARK    GeneRIF: miR-5581 Contributes to Osteoarthritis by Targeting NRF1
            to Disturb the Proliferation and Functions of Chondrocytes.
REFERENCE   2  (residues 1 to 479)
  AUTHORS   Meng Z, Liang B, Wu Y, Liu C, Wang H, Du Y, Gan L, Gao E, Lau WB,
            Christopher TA, Lopez BL, Koch WJ, Ma X, Zhao F, Wang Y and Zhao J.
  TITLE     Hypoadiponectinemia-induced upregulation of microRNA449b
            downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury
            in diabetic mice
  JOURNAL   J Mol Cell Cardiol 182, 1-14 (2023)
   PUBMED   37437402
  REMARK    GeneRIF: Hypoadiponectinemia-induced upregulation of microRNA449b
            downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury
            in diabetic mice.
REFERENCE   3  (residues 1 to 479)
  AUTHORS   Zhao T, Zhang J, Lei H, Meng Y, Cheng H, Zhao Y, Geng G, Mu C, Chen
            L, Liu Q, Luo Q, Zhang C, Long Y, Su J, Wang Y, Li Z, Sun J, Chen
            G, Li Y, Liao X, Shang Y, Hu G, Chen Q and Zhu Y.
  TITLE     NRF1-mediated mitochondrial biogenesis antagonizes innate antiviral
            immunity
  JOURNAL   EMBO J 42 (16), e113258 (2023)
   PUBMED   37409632
  REMARK    GeneRIF: NRF1-mediated mitochondrial biogenesis antagonizes innate
            antiviral immunity.
REFERENCE   4  (residues 1 to 479)
  AUTHORS   Akl MG, Baccetto R, Stebbings BM, Li L and Widenmaier SB.
  TITLE     Euglycemia is affected by stress defense factor hepatocyte NRF1,
            but not NRF2
  JOURNAL   Biochem Biophys Res Commun 668, 96-103 (2023)
   PUBMED   37245295
  REMARK    GeneRIF: Euglycemia is affected by stress defense factor hepatocyte
            NRF1, but not NRF2.
REFERENCE   5  (residues 1 to 479)
  AUTHORS   Akl MG, Li L, Baccetto R, Phanse S, Zhang Q, Trites MJ, McDonald S,
            Aoki H, Babu M and Widenmaier SB.
  TITLE     Complementary gene regulation by NRF1 and NRF2 protects against
            hepatic cholesterol overload
  JOURNAL   Cell Rep 42 (4), 112399 (2023)
   PUBMED   37060561
  REMARK    GeneRIF: Complementary gene regulation by NRF1 and NRF2 protects
            against hepatic cholesterol overload.
            Erratum:[Cell Rep. 2023 Jul 25;42(7):112872. PMID: 37454293]
REFERENCE   6  (residues 1 to 479)
  AUTHORS   Carmona MC, Iglesias R, Obregon MJ, Darlington GJ, Villarroya F and
            Giralt M.
  TITLE     Mitochondrial biogenesis and thyroid status maturation in brown fat
            require CCAAT/enhancer-binding protein alpha
  JOURNAL   J Biol Chem 277 (24), 21489-21498 (2002)
   PUBMED   11940593
REFERENCE   7  (residues 1 to 479)
  AUTHORS   Huo L and Scarpulla RC.
  TITLE     Mitochondrial DNA instability and peri-implantation lethality
            associated with targeted disruption of nuclear respiratory factor 1
            in mice
  JOURNAL   Mol Cell Biol 21 (2), 644-654 (2001)
   PUBMED   11134350
REFERENCE   8  (residues 1 to 479)
  AUTHORS   Schaefer L, Engman H and Miller JB.
  TITLE     Coding sequence, chromosomal localization, and expression pattern
            of Nrf1: the mouse homolog of Drosophila erect wing
  JOURNAL   Mamm Genome 11 (2), 104-110 (2000)
   PUBMED   10656923
REFERENCE   9  (residues 1 to 479)
  AUTHORS   Huo L and Scarpulla RC.
  TITLE     Multiple 5'-untranslated exons in the nuclear respiratory factor 1
            gene span 47 kb and contribute to transcript heterogeneity and
            translational efficiency
  JOURNAL   Gene 233 (1-2), 213-224 (1999)
   PUBMED   10375638
REFERENCE   10 (residues 1 to 479)
  AUTHORS   Virbasius CA, Virbasius JV and Scarpulla RC.
  TITLE     NRF-1, an activator involved in nuclear-mitochondrial interactions,
            utilizes a new DNA-binding domain conserved in a family of
            developmental regulators
  JOURNAL   Genes Dev 7 (12A), 2431-2445 (1993)
   PUBMED   8253388
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134897.4 and AC153632.2.
            
            On Aug 1, 2022 this sequence version replaced XP_030111079.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13948564.4538956.1,
                                           SRR17253011.7130258.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 12.47 cM"
     Protein         1..479
                     /product="nuclear respiratory factor 1 isoform k"
                     /note="NRF-1; alpha-pal; alpha palindromic-binding
                     protein"
                     /calculated_mol_wt=51067
     Region          87..283
                     /region_name="Nrf1_DNA-bind"
                     /note="NLS-binding and DNA-binding and dimerization
                     domains of Nrf1; pfam10491"
                     /db_xref="CDD:402218"
     CDS             1..479
                     /gene="Nrf1"
                     /gene_synonym="D6Ertd415e"
                     /coded_by="NM_001410234.1:271..1710"
                     /note="isoform k is encoded by transcript variant 24"
                     /db_xref="GeneID:18181"
                     /db_xref="MGI:MGI:1332235"
ORIGIN      
        1 meehgvtqte hmatieahav aqqvqqvhva tytehsmlsa dedspssped tsyddsdiln
       61 staadevtah laaagpvgma aaaavatgkk rkrphvfesn psirkrqqtr llrklratld
      121 eyttrvgqqa ivlcispskp npvfkvfgaa plenvvrkyk smiledlesa laehapapqe
      181 vnselpplti dgipvsvdkm tqaqlrafip emlkystgrg kpgwgkesck piwwpedipw
      241 anvrsdvrte eqkqrvswtq alrtivkncy kqhgredlly afedqqtqtq attthsiahl
      301 vpsqtvvqtf snpdgtvsli qvgtgatvat ladaselptt vtvaqvnysa vadgeveqnw
      361 atlqggemti qttqaseatq avaslaeaav aasqemqqga tvtmalnsea aahavatlae
      421 atlqgggqiv lsgetaaavg altgvqdang lfmadcggyk wilarrlqvg sslgregss
//
LOCUS       NP_038777                129 aa            linear   ROD 09-OCT-2023
DEFINITION  tumor necrosis factor receptor superfamily member 12A isoform 1
            precursor [Mus musculus].
ACCESSION   NP_038777
VERSION     NP_038777.2
DBSOURCE    REFSEQ: accession NM_013749.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 129)
  AUTHORS   Ruiz BI, Lowman XH, Yang Y, Fan Q, Wang T, Wu H, Hanse EA and Kong
            M.
  TITLE     Alpha-Ketoglutarate Regulates Tnfrsf12a/Fn14 Expression via Histone
            Modification and Prevents Cancer-Induced Cachexia
  JOURNAL   Genes (Basel) 14 (9), 1818 (2023)
   PUBMED   37761958
  REMARK    GeneRIF: Alpha-Ketoglutarate Regulates Tnfrsf12a/Fn14 Expression
            via Histone Modification and Prevents Cancer-Induced Cachexia.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 129)
  AUTHORS   Short C, Zhong A, Xu J, Mahdi E, Glazier A, Malkoff N, Noriega N,
            Yeo T, Asahina K and Wang KS.
  TITLE     TWEAK/FN14 promotes profibrogenic pathway activation in
            Prominin-1-expressing hepatic progenitor cells in biliary atresia
  JOURNAL   Hepatology 77 (5), 1639-1653 (2023)
   PUBMED   36626628
  REMARK    GeneRIF: TWEAK/FN14 promotes profibrogenic pathway activation in
            Prominin-1-expressing hepatic progenitor cells in biliary atresia.
REFERENCE   3  (residues 1 to 129)
  AUTHORS   Wang X, Lu M, Gu H, Xiao T, Hu G, Luo M, Guo X and Xia Y.
  TITLE     Conjugation of the Fn14 Ligand to a SMAC Mimetic Selectively
            Suppresses Experimental Squamous Cell Carcinoma in Mice
  JOURNAL   J Invest Dermatol 143 (2), 242-253 (2023)
   PUBMED   36063885
  REMARK    GeneRIF: Conjugation of the Fn14 Ligand to a SMAC Mimetic
            Selectively Suppresses Experimental Squamous Cell Carcinoma in
            Mice.
REFERENCE   4  (residues 1 to 129)
  AUTHORS   Tomaz da Silva M, Joshi AS, Koike TE, Roy A, Mathukumalli K,
            Sopariwala DH, Narkar VA and Kumar A.
  TITLE     Targeted ablation of Fn14 receptor improves exercise capacity and
            inhibits neurogenic muscle atrophy
  JOURNAL   FASEB J 36 (12), e22666 (2022)
   PUBMED   36412933
  REMARK    GeneRIF: Targeted ablation of Fn14 receptor improves exercise
            capacity and inhibits neurogenic muscle atrophy.
REFERENCE   5  (residues 1 to 129)
  AUTHORS   Ortega MA, Villiger RK, Harrison-Chau M, Lieu S, Tamashiro KK, Lee
            AJ, Fujimoto BA, Patwardhan GY, Kepler J and Fogelgren B.
  TITLE     Exocyst inactivation in urothelial cells disrupts autophagy and
            activates non-canonical NF-kappaB signaling
  JOURNAL   Dis Model Mech 15 (10) (2022)
   PUBMED   36004645
REFERENCE   6  (residues 1 to 129)
  AUTHORS   Polek TC, Talpaz M, Darnay BG and Spivak-Kroizman T.
  TITLE     TWEAK mediates signal transduction and differentiation of RAW264.7
            cells in the absence of Fn14/TweakR. Evidence for a second TWEAK
            receptor
  JOURNAL   J Biol Chem 278 (34), 32317-32323 (2003)
   PUBMED   12794080
  REMARK    GeneRIF: findings show that the Fn14/TWEAK receptor (TweakR) was
            not responsible for the osteoclastic effect of TWEAK on RAW cells
REFERENCE   7  (residues 1 to 129)
  AUTHORS   Brown SA, Richards CM, Hanscom HN, Feng SL and Winkles JA.
  TITLE     The Fn14 cytoplasmic tail binds
            tumour-necrosis-factor-receptor-associated factors 1, 2, 3 and 5
            and mediates nuclear factor-kappaB activation
  JOURNAL   Biochem J 371 (Pt 2), 395-403 (2003)
   PUBMED   12529173
  REMARK    GeneRIF: The cytoplasmic tail of this protein binds
            tumour-necrosis-factor-receptor-associated factors 1, 2, 3 and 5
            and mediates nuclear factor-kappaB activation.
REFERENCE   8  (residues 1 to 129)
  AUTHORS   Wiley SR, Cassiano L, Lofton T, Davis-Smith T, Winkles JA, Lindner
            V, Liu H, Daniel TO, Smith CA and Fanslow WC.
  TITLE     A novel TNF receptor family member binds TWEAK and is implicated in
            angiogenesis
  JOURNAL   Immunity 15 (5), 837-846 (2001)
   PUBMED   11728344
REFERENCE   9  (residues 1 to 129)
  AUTHORS   Feng SL, Guo Y, Factor VM, Thorgeirsson SS, Bell DW, Testa JR,
            Peifley KA and Winkles JA.
  TITLE     The Fn14 immediate-early response gene is induced during liver
            regeneration and highly expressed in both human and murine
            hepatocellular carcinomas
  JOURNAL   Am J Pathol 156 (4), 1253-1261 (2000)
   PUBMED   10751351
REFERENCE   10 (residues 1 to 129)
  AUTHORS   Meighan-Mantha RL, Hsu DK, Guo Y, Brown SA, Feng SL, Peifley KA,
            Alberts GF, Copeland NG, Gilbert DJ, Jenkins NA, Richards CM and
            Winkles JA.
  TITLE     The mitogen-inducible Fn14 gene encodes a type I transmembrane
            protein that modulates fibroblast adhesion and migration
  JOURNAL   J Biol Chem 274 (46), 33166-33176 (1999)
   PUBMED   10551889
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK160136.1 and AI853177.1.
            
            On Jun 13, 2009 this sequence version replaced NP_038777.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF156164.1, AK160136.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN02415127 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..129
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 11.99 cM"
     Protein         1..129
                     /product="tumor necrosis factor receptor superfamily
                     member 12A isoform 1 precursor"
                     /note="tweak-receptor; FGF-inducible 14; fibroblast growth
                     factor-regulated protein 2; fibroblast growth
                     factor-inducible immediate-early response protein 14; type
                     I transmembrane protein Fn14"
                     /calculated_mol_wt=10833
     Region          1..129
                     /region_name="stn_TNFRSF12A"
                     /note="tumor necrosis factor receptor stn_TNFRSF12A_TNFR
                     domain; pfam12191"
                     /db_xref="CDD:403424"
     sig_peptide     1..27
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=2826
     Region          9..33
                     /region_name="CRD1"
                     /note="CRD1 [structural motif]"
                     /db_xref="CDD:276918"
     Region          36..104
                     /region_name="CRD2"
                     /note="CRD2 [structural motif]"
                     /db_xref="CDD:276918"
     Region          36..67
                     /region_name="TNFR-Cys, atypical"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CR75.1)"
     Site            81..101
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CR75.1)"
     CDS             1..129
                     /gene="Tnfrsf12a"
                     /gene_synonym="Fn14; HPIP; TWEAK-R; TweakR"
                     /coded_by="NM_013749.2:30..419"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS28456.1"
                     /db_xref="GeneID:27279"
                     /db_xref="MGI:MGI:1351484"
ORIGIN      
        1 masawprslp qilvlgfglv lmraaageqa pgtspcssgs swsadldkcm dcascparph
       61 sdfclgcaaa ppahfrllwp ilggalslvl vlalvssflv wrrcrrrekf ttpieetgge
      121 gcpgvaliq
//
LOCUS       NP_001392989             143 aa            linear   ROD 09-OCT-2023
DEFINITION  bcl-2-like protein 11 isoform 6 [Mus musculus].
ACCESSION   NP_001392989
VERSION     NP_001392989.1
DBSOURCE    REFSEQ: accession NM_001406060.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 143)
  AUTHORS   Jiang M, Wang XB and Jiang S.
  TITLE     circ_0000018 downregulation peripherally ameliorates
            neuroprotection against acute ischemic stroke through the
            miR-871/BCL2L11 axis
  JOURNAL   Mol Med Rep 28 (5) (2023)
   PUBMED   37772397
  REMARK    GeneRIF: circ_0000018 downregulation peripherally ameliorates
            neuroprotection against acute ischemic stroke through the
            miR-871/BCL2L11 axis.
REFERENCE   2  (residues 1 to 143)
  AUTHORS   Lu Y, Tang K, Wang S, Tian Z, Fan Y, Li B, Wang M, Zhao J and Xie
            J.
  TITLE     Dach1 deficiency drives alveolar epithelium apoptosis in pulmonary
            fibrosis via modulating C-Jun/Bim activity
  JOURNAL   Transl Res 257, 54-65 (2023)
   PUBMED   36754276
  REMARK    GeneRIF: Dach1 deficiency drives alveolar epithelium apoptosis in
            pulmonary fibrosis via modulating C-Jun/Bim activity.
REFERENCE   3  (residues 1 to 143)
  AUTHORS   Nguyen HV, Vandenberg CJ, Robati MR, Ng AP and Cory S.
  TITLE     MNT suppresses T cell apoptosis via BIM and is critical for T
            lymphomagenesis
  JOURNAL   Cell Death Differ 30 (4), 1018-1032 (2023)
   PUBMED   36755068
  REMARK    GeneRIF: MNT suppresses T cell apoptosis via BIM and is critical
            for T lymphomagenesis.
REFERENCE   4  (residues 1 to 143)
  AUTHORS   Chen H, Bai Y, Kobayashi M, Xiao S, Cai W, Barajas S, Chen S, Miao
            J, Meke FN, Vemula S, Ropa JP, Croop JM, Boswell HS, Wan J, Jia Y,
            Liu H, Li LS, Altman JK, Eklund EA, Ji P, Tong W, Band H, Huang DT,
            Platanias LC, Zhang ZY and Liu Y.
  TITLE     PRL2 phosphatase enhances oncogenic FLT3 signaling via
            dephosphorylation of the E3 ubiquitin ligase CBL at tyrosine 371
  JOURNAL   Blood 141 (3), 244-259 (2023)
   PUBMED   36206490
REFERENCE   5  (residues 1 to 143)
  AUTHORS   Brahma MK, Xiao P, Popa M, Negueruela J, Vandenbempt V, Demine S,
            Cardozo AK and Gurzov EN.
  TITLE     Nova1 or Bim Deficiency in Pancreatic beta-Cells Does Not Alter
            Multiple Low-Dose Streptozotocin-Induced Diabetes and Diet-Induced
            Obesity in Mice
  JOURNAL   Nutrients 14 (18), 3866 (2022)
   PUBMED   36145242
  REMARK    GeneRIF: Nova1 or Bim Deficiency in Pancreatic beta-Cells Does Not
            Alter Multiple Low-Dose Streptozotocin-Induced Diabetes and
            Diet-Induced Obesity in Mice.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 143)
  AUTHORS   Bouillet P, Zhang LC, Huang DC, Webb GC, Bottema CD, Shore P, Eyre
            HJ, Sutherland GR and Adams JM.
  TITLE     Gene structure alternative splicing, and chromosomal localization
            of pro-apoptotic Bcl-2 relative Bim
  JOURNAL   Mamm Genome 12 (2), 163-168 (2001)
   PUBMED   11210187
REFERENCE   7  (residues 1 to 143)
  AUTHORS   Bouillet P, Metcalf D, Huang DC, Tarlinton DM, Kay TW, Kontgen F,
            Adams JM and Strasser A.
  TITLE     Proapoptotic Bcl-2 relative Bim required for certain apoptotic
            responses, leukocyte homeostasis, and to preclude autoimmunity
  JOURNAL   Science 286 (5445), 1735-1738 (1999)
   PUBMED   10576740
REFERENCE   8  (residues 1 to 143)
  AUTHORS   Puthalakath H, Huang DC, O'Reilly LA, King SM and Strasser A.
  TITLE     The proapoptotic activity of the Bcl-2 family member Bim is
            regulated by interaction with the dynein motor complex
  JOURNAL   Mol Cell 3 (3), 287-296 (1999)
   PUBMED   10198631
REFERENCE   9  (residues 1 to 143)
  AUTHORS   Reed JC.
  TITLE     Bcl-2 family proteins
  JOURNAL   Oncogene 17 (25), 3225-3236 (1998)
   PUBMED   9916985
  REMARK    Review article
REFERENCE   10 (residues 1 to 143)
  AUTHORS   O'Connor L, Strasser A, O'Reilly LA, Hausmann G, Adams JM, Cory S
            and Huang DC.
  TITLE     Bim: a novel member of the Bcl-2 family that promotes apoptosis
  JOURNAL   EMBO J 17 (2), 384-395 (1998)
   PUBMED   9430630
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL805950.11.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422600.5859.1,
                                           SRR1660815.60451.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..143
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 62.23 cM"
     Protein         1..143
                     /product="bcl-2-like protein 11 isoform 6"
                     /note="bcl-2-like protein 11; bcl2-interacting mediator of
                     cell death; Bcl2 interacting mediator of cell death;
                     BCL2-like 11 (apoptosis facilitator)"
                     /calculated_mol_wt=15972
     Region          4..40
                     /region_name="Bim_N"
                     /note="Bim protein N-terminus; pfam06773"
                     /db_xref="CDD:429111"
     Region          73..110
                     /region_name="Bclx_interact"
                     /note="Bcl-x interacting, BH3 domain; pfam08945"
                     /db_xref="CDD:430337"
     CDS             1..143
                     /gene="Bcl2l11"
                     /gene_synonym="1500006F24Rik; bcl2-L-11; Bim; Bod"
                     /coded_by="NM_001406060.1:221..652"
                     /note="isoform 6 is encoded by transcript variant 9"
                     /db_xref="GeneID:12125"
                     /db_xref="MGI:MGI:1197519"
ORIGIN      
        1 makqpsdvss ecdreggqlq paerppqlrp gaptslqtep qdrspapmsc dkstqtpspp
       61 cqafnhylsa masirqsqee pedlrpeiri aqelrrigde fnetytrrvr tsphpqrkcn
      121 cgdmapfctl rylspnsalt wci
//
LOCUS       NP_033810               1105 aa            linear   ROD 09-OCT-2023
DEFINITION  AP-3 complex subunit beta-1 [Mus musculus].
ACCESSION   NP_033810
VERSION     NP_033810.2
DBSOURCE    REFSEQ: accession NM_009680.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1105)
  AUTHORS   Xu H, Oses-Prieto JA, Khvotchev M, Jain S, Liang J, Burlingame A
            and Edwards RH.
  TITLE     Adaptor protein AP-3 produces synaptic vesicles that release at
            high frequency by recruiting phospholipid flippase ATP8A1
  JOURNAL   Nat Neurosci 26 (10), 1685-1700 (2023)
   PUBMED   37723322
  REMARK    GeneRIF: Adaptor protein AP-3 produces synaptic vesicles that
            release at high frequency by recruiting phospholipid flippase
            ATP8A1.
REFERENCE   2  (residues 1 to 1105)
  AUTHORS   Poli V, Di Gioia M, Sola-Visner M, Granucci F, Frelinger AL 3rd,
            Michelson AD and Zanoni I.
  TITLE     Inhibition of transcription factor NFAT activity in activated
            platelets enhances their aggregation and exacerbates gram-negative
            bacterial septicemia
  JOURNAL   Immunity 55 (2), 224-236 (2022)
   PUBMED   34995475
REFERENCE   3  (residues 1 to 1105)
  AUTHORS   Kook S, Wang P, Meng S, Jetter CS, Sucre JMS, Benjamin JT, Gokey
            JJ, Hanby HA, Jaume A, Goetzl L, Marks MS and Guttentag SH.
  TITLE     AP-3-dependent targeting of flippase ATP8A1 to lamellar bodies
            suppresses activation of YAP in alveolar epithelial type 2 cells
  JOURNAL   Proc Natl Acad Sci U S A 118 (20) (2021)
   PUBMED   33990468
REFERENCE   4  (residues 1 to 1105)
  AUTHORS   Yuan Y, Liu T, Huang X, Chen Y, Zhang W, Li T, Yang L, Chen Q, Wang
            Y, Wei A and Li W.
  TITLE     A zinc transporter, transmembrane protein 163, is critical for the
            biogenesis of platelet dense granules
  JOURNAL   Blood 137 (13), 1804-1817 (2021)
   PUBMED   33513603
REFERENCE   5  (residues 1 to 1105)
  AUTHORS   Cuevas-Mora K, Roque W, Shaghaghi H, Gochuico BR, Rosas IO, Summer
            R and Romero F.
  TITLE     Hermansky-Pudlak syndrome-2 alters mitochondrial homeostasis in the
            alveolar epithelium of the lung
  JOURNAL   Respir Res 22 (1), 49 (2021)
   PUBMED   33557836
  REMARK    GeneRIF: Hermansky-Pudlak syndrome-2 alters mitochondrial
            homeostasis in the alveolar epithelium of the lung.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1105)
  AUTHORS   Timmerman V, Nelis E, Van Hul W, Nieuwenhuijsen BW, Chen KL, Wang
            S, Ben Othman K, Cullen B, Leach RJ, Hanemann CO et al.
  TITLE     The peripheral myelin protein gene PMP-22 is contained within the
            Charcot-Marie-Tooth disease type 1A duplication
  JOURNAL   Nat Genet 1 (3), 171-175 (1992)
   PUBMED   1303230
  REMARK    Erratum:[Nat Genet 1992 Sep;2(1):84]
REFERENCE   7  (residues 1 to 1105)
  AUTHORS   Swank RT, Sweet HO, Davisson MT, Reddington M and Novak EK.
  TITLE     Sandy: a new mouse model for platelet storage pool deficiency
  JOURNAL   Genet Res 58 (1), 51-62 (1991)
   PUBMED   1936982
REFERENCE   8  (residues 1 to 1105)
  AUTHORS   Holcombe RF, Stephenson DA, Zweidler A, Stewart RM, Chapman VM and
            Seidman JG.
  TITLE     Linkage of loci associated with two pigment mutations on mouse
            chromosome 13
  JOURNAL   Genet Res 58 (1), 41-50 (1991)
   PUBMED   1682216
REFERENCE   9  (residues 1 to 1105)
  AUTHORS   McGarry,M.P., Novak,E.K. and Swank,R.T.
  TITLE     Progenitor cell defect correctable by bone marrow transplantation
            in five independent mouse models of platelet storage pool
            deficiency
  JOURNAL   Exp Hematol 14 (4), 261-265 (1986)
   PUBMED   3516713
REFERENCE   10 (residues 1 to 1105)
  AUTHORS   Novak,E.K. and Swank,R.T.
  TITLE     Lysosomal dysfunctions associated with mutations at mouse pigment
            genes
  JOURNAL   Genetics 92 (1), 189-204 (1979)
   PUBMED   115747
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK171595.1, AK143559.1, AK163996.1, CK129787.1 and BQ032961.1.
            
            On Dec 19, 2007 this sequence version replaced NP_033810.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF103809.2, SRR9219380.26049.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1105
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 49.22 cM"
     Protein         1..1105
                     /product="AP-3 complex subunit beta-1"
                     /note="beta3A-adaptin; adaptor protein complex AP-3 beta-1
                     subunit; adapter-related protein complex 3 subunit beta-1;
                     clathrin assembly protein complex 3 beta-1 large chain;
                     beta-3A-adaptin; adaptor protein complex AP-3 subunit
                     beta-1; recombination induced mutation 2; adaptor-related
                     protein complex 3 subunit beta-1; adaptor-related protein
                     complex AP-3 beta 1 subunit"
                     /calculated_mol_wt=122610
     Region          1..26
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z1T1.2)"
     Region          46..582
                     /region_name="Adaptin_N"
                     /note="Adaptin N terminal region; pfam01602"
                     /db_xref="CDD:396262"
     Site            order(96..97,100,103..104,133..134,137,140..141,144,
                     168..169,172,175..176,179,205..206,209,212..213)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          116..144
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          150..180
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          188..213
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          271..292
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z1T1.2)"
     Site            276
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:19144319, ECO:0007744|PubMed:21183079;
                     propagated from UniProtKB/Swiss-Prot (Q9Z1T1.2)"
     Site            610
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O00203; propagated from
                     UniProtKB/Swiss-Prot (Q9Z1T1.2)"
     Region          668..824
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z1T1.2)"
     Region          <734..792
                     /region_name="SEEEED"
                     /note="Serine-rich region of AP3B1, clathrin-adaptor
                     complex; pfam14797"
                     /db_xref="CDD:434218"
     Site            761
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O00203; propagated from
                     UniProtKB/Swiss-Prot (Q9Z1T1.2)"
     Site            763
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O00203; propagated from
                     UniProtKB/Swiss-Prot (Q9Z1T1.2)"
     Region          824..969
                     /region_name="AP3B1_C"
                     /note="Clathrin-adaptor complex-3 beta-1 subunit
                     C-terminal; pfam14796"
                     /db_xref="CDD:434217"
     CDS             1..1105
                     /gene="Ap3b1"
                     /gene_synonym="AP-3; beta3A; Hps2; pe; pearl; rim2"
                     /coded_by="NM_009680.3:145..3462"
                     /db_xref="CCDS:CCDS26693.1"
                     /db_xref="GeneID:11774"
                     /db_xref="MGI:MGI:1333879"
ORIGIN      
        1 mssnsfayne qsgggeaael gqeatstisp sgafglfssd wkknedlkqm lesnkdsakl
       61 damkrivgmi akgknaself pavvknvask nieikklvyv ylvryaeeqq dlallsistf
      121 qralkdpnql irasalrvls sirvpiivpv mmlaikeasa dlspyvrkna ahaiqklysl
      181 dpeqkemlie viekllkdks tlvagsvvma feevcpdrid lihrnyrklc nllvdveewg
      241 qvviihmltr yartqfvspw redggledne knfyeseeee eekekssrkk syamdpdhrl
      301 lirntkpllq srnaavvmav aqlywhispk seagvisksl vrllrsnrev qyivlqniat
      361 msierkgmfe pylksfyvrs tdptmiktlk leiltnlane anistllref qtyvrsqdkq
      421 faaatiqtig rcatsisevt dtclnglvcl lsnrdeivva esvvvikkll qmqpaqhgei
      481 irhmakllds itvpvarasi lwligencer vpkiapdvlr kmaksftsed dlvklqilnl
      541 aaklyltnsk qtklltqyil nlgkydqnyd irdrtrfirq livpneksga lskyakkifl
      601 apkpaplles pfkdrdrfql gtlshtlnik asgylelsnw pevapdpsvr nveviesake
      661 wtplgktkke kpmkkfyses eeeededede deeeeekede denpsdsssd sesgsgsesg
      721 dtgtedssed sssgqdsetg sqaeaerqkv akrnsktkrk sdsenrekkn enskasesss
      781 eesssmedss sesesesgsd sepaprnvap akerkpqqer hppskdvfll dlddfnpvst
      841 pvalptpals psliadlegl nlstsssvin vstpvfvptk thellhrmhg kglaahycfp
      901 rqpcifsdkm vsvqitltnt sdrkienihi ggkglpvgmq mhafhpidsl epkgsvtvsv
      961 gidfcdstqt asfqlctkdd cfnvtlqppv gellspvams ekdfkkeqgt ltgmnetsat
     1021 liaapqnftp smilqkvvnv anlgavpssq dnvhrfaart vhsgslmlvt velkegstaq
     1081 liintektvi gsvllrelkp vlsqg
//
LOCUS       NP_083618                295 aa            linear   ROD 09-OCT-2023
DEFINITION  non-homologous end-joining factor 1 [Mus musculus].
ACCESSION   NP_083618 XP_997840
VERSION     NP_083618.3
DBSOURCE    REFSEQ: accession NM_029342.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 295)
  AUTHORS   Bery A, Etienne O, Mouton L, Mokrani S, Granotier-Beckers C,
            Gauthier LR, Feat-Vetel J, Kortulewski T, Peres EA, Desmaze C,
            Lestaveal P, Barroca V, Laugeray A, Boumezbeur F, Abramovski V,
            Mortaud S, Menuet A, Le Bihan D, Villartay JP and Boussin FD.
  TITLE     XLF/Cernunnos loss impairs mouse brain development by altering
            symmetric proliferative divisions of neural progenitors
  JOURNAL   Cell Rep 42 (4), 112342 (2023)
   PUBMED   37027298
  REMARK    GeneRIF: XLF/Cernunnos loss impairs mouse brain development by
            altering symmetric proliferative divisions of neural progenitors.
REFERENCE   2  (residues 1 to 295)
  AUTHORS   Vincendeau E, Wei W, Zhang X, Planchais C, Yu W, Lenden-Hasse H,
            Cokelaer T, Pipoli da Fonseca J, Mouquet H, Adams DJ, Alt FW,
            Jackson SP, Balmus G, Lescale C and Deriano L.
  TITLE     SHLD1 is dispensable for 53BP1-dependent V(D)J recombination but
            critical for productive class switch recombination
  JOURNAL   Nat Commun 13 (1), 3707 (2022)
   PUBMED   35764636
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 295)
  AUTHORS   Roch B, Abramowski V, Etienne O, Musilli S, David P, Charbonnier
            JB, Callebaut I, Boussin FD and de Villartay JP.
  TITLE     An XRCC4 mutant mouse, a model for human X4 syndrome, reveals
            interplays with Xlf, PAXX, and ATM in lymphoid development
  JOURNAL   Elife 10, e69353 (2021)
   PUBMED   34519267
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 295)
  AUTHORS   Gago-Fuentes R and Oksenych V.
  TITLE     Non-Homologous End Joining Factors XLF, PAXX and DNA-PKcs Maintain
            the Neural Stem and Progenitor Cell Population
  JOURNAL   Biomolecules 11 (1), 20 (2020)
   PUBMED   33379193
  REMARK    GeneRIF: Non-Homologous End Joining Factors XLF, PAXX and DNA-PKcs
            Maintain the Neural Stem and Progenitor Cell Population.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 295)
  AUTHORS   Castaneda-Zegarra S, Zhang Q, Alirezaylavasani A,
            Fernandez-Berrocal M, Yao R and Oksenych V.
  TITLE     Leaky severe combined immunodeficiency in mice lacking
            non-homologous end joining factors XLF and MRI
  JOURNAL   Aging (Albany NY) 12 (23), 23578-23597 (2020)
   PUBMED   33289702
  REMARK    GeneRIF: Leaky severe combined immunodeficiency in mice lacking
            non-homologous end joining factors XLF and MRI.
REFERENCE   6  (residues 1 to 295)
  AUTHORS   Ahnesorg P, Smith P and Jackson SP.
  TITLE     XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA
            nonhomologous end-joining
  JOURNAL   Cell 124 (2), 301-313 (2006)
   PUBMED   16439205
REFERENCE   7  (residues 1 to 295)
  AUTHORS   Buck D, Malivert L, de Chasseval R, Barraud A, Fondaneche MC, Sanal
            O, Plebani A, Stephan JL, Hufnagel M, le Deist F, Fischer A,
            Durandy A, de Villartay JP and Revy P.
  TITLE     Cernunnos, a novel nonhomologous end-joining factor, is mutated in
            human immunodeficiency with microcephaly
  JOURNAL   Cell 124 (2), 287-299 (2006)
   PUBMED   16439204
REFERENCE   8  (residues 1 to 295)
  AUTHORS   Taniwaki T, Haruna K, Nakamura H, Sekimoto T, Oike Y, Imaizumi T,
            Saito F, Muta M, Soejima Y, Utoh A, Nakagata N, Araki M, Yamamura K
            and Araki K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   9  (residues 1 to 295)
  AUTHORS   VanBuren V, Piao Y, Dudekula DB, Qian Y, Carter MG, Martin PR,
            Stagg CA, Bassey UC, Aiba K, Hamatani T, Kargul GJ, Luo AG, Kelso
            J, Hide W and Ko MS.
  TITLE     Assembly, verification, and initial annotation of the NIA mouse
            7.4K cDNA clone set
  JOURNAL   Genome Res 12 (12), 1999-2003 (2002)
   PUBMED   12466305
REFERENCE   10 (residues 1 to 295)
  AUTHORS   Araki K, Imaizumi T, Sekimoto T, Yoshinobu K, Yoshimuta J, Akizuki
            M, Miura K, Araki M and Yamamura K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY095373.1, BC107252.1, BY432477.1 and AV512639.1.
            
            On Oct 20, 2007 this sequence version replaced NP_083618.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164143
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..295
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 38.56 cM"
     Protein         1..295
                     /product="non-homologous end-joining factor 1"
                     /note="XRCC4-like factor; protein cernunnos; nonhomologous
                     end-joining factor 1"
                     /calculated_mol_wt=32608
     Region          1..135
                     /region_name="Globular head.
                     /evidence=ECO:0000250|UniProtKB:Q9H9Q4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3KNJ2.1)"
     Region          12..175
                     /region_name="XLF"
                     /note="XLF-Cernunnos, XRcc4-like factor, NHEJ component;
                     pfam09302"
                     /db_xref="CDD:430513"
     Site            115
                     /site_type="other"
                     /note="Leu-lock. /evidence=ECO:0000250|UniProtKB:Q9H9Q4;
                     propagated from UniProtKB/Swiss-Prot (Q3KNJ2.1)"
     Site            132
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H9Q4; propagated from
                     UniProtKB/Swiss-Prot (Q3KNJ2.1)"
     Region          228..295
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3KNJ2.1)"
     Site            245
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q3KNJ2.1)"
     Site            262
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9H9Q4; propagated from
                     UniProtKB/Swiss-Prot (Q3KNJ2.1)"
     Region          285..295
                     /region_name="XLM. /evidence=ECO:0000250|UniProtKB:Q9H9Q4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3KNJ2.1)"
     CDS             1..295
                     /gene="Nhej1"
                     /gene_synonym="1700029B21Rik; cernunnos; XLF"
                     /coded_by="NM_029342.4:170..1057"
                     /db_xref="GeneID:75570"
                     /db_xref="MGI:MGI:1922820"
ORIGIN      
        1 meeleqdlll qpwawlqlae nsllakvsit khgyallisd lqqvwheqvd tsvvsqrake
       61 lnkrltappa allchldeal rplfkdsahp skatfscdrg eeglilrvqs elsglpfswh
      121 fhcipasssl vsqhlihplm gvslalqshv relaallrmk dleiqayqes gavlsrsrlk
      181 tepfeensfl eqfmaeklpe acavgdgkpf amslqslyva vtkqqiqarq ahkdsgetqa
      241 ssstsprgtd nqpeepvsls stlsepeyep vaasgpmhra rlvkskrkkp rglfs
//
LOCUS       NP_001390660             733 aa            linear   ROD 09-OCT-2023
DEFINITION  transcriptional repressor CTCF isoform 4 [Mus musculus].
ACCESSION   NP_001390660 XP_036009641
VERSION     NP_001390660.1
DBSOURCE    REFSEQ: accession NM_001403731.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 733)
  AUTHORS   Hewitt SC, Gruzdev A, Willson CJ, Wu SP, Lydon JP, Galjart N and
            DeMayo FJ.
  TITLE     Chromatin architectural factor CTCF is essential for
            progesterone-dependent uterine maturation
  JOURNAL   FASEB J 37 (8), e23103 (2023)
   PUBMED   37489832
  REMARK    GeneRIF: Chromatin architectural factor CTCF is essential for
            progesterone-dependent uterine maturation.
REFERENCE   2  (residues 1 to 733)
  AUTHORS   Smits WK, Vermeulen C, Hagelaar R, Kimura S, Vroegindeweij EM,
            Buijs-Gladdines JGCAM, van de Geer E, Verstegen MJAM, Splinter E,
            van Reijmersdal SV, Buijs A, Galjart N, van Eyndhoven W, van Min M,
            Kuiper R, Kemmeren P, Mullighan CG, de Laat W and Meijerink JPP.
  TITLE     Elevated enhancer-oncogene contacts and higher oncogene expression
            levels by recurrent CTCF inactivating mutations in acute T cell
            leukemia
  JOURNAL   Cell Rep 42 (4), 112373 (2023)
   PUBMED   37060567
REFERENCE   3  (residues 1 to 733)
  AUTHORS   Wang B, Ji L and Bian Q.
  TITLE     SATB1 regulates 3D genome architecture in T cells by constraining
            chromatin interactions surrounding CTCF-binding sites
  JOURNAL   Cell Rep 42 (4), 112323 (2023)
   PUBMED   37000624
  REMARK    GeneRIF: SATB1 regulates 3D genome architecture in T cells by
            constraining chromatin interactions surrounding CTCF-binding sites.
REFERENCE   4  (residues 1 to 733)
  AUTHORS   Marina-Zarate E, Rodriguez-Ronchel A, Gomez MJ, Sanchez-Cabo F and
            Ramiro AR.
  TITLE     Low-affinity CTCF binding drives transcriptional regulation whereas
            high-affinity binding encompasses architectural functions
  JOURNAL   iScience 26 (3), 106106 (2023)
   PUBMED   36852270
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 733)
  AUTHORS   Hsieh TS, Cattoglio C, Slobodyanyuk E, Hansen AS, Darzacq X and
            Tjian R.
  TITLE     Enhancer-promoter interactions and transcription are largely
            maintained upon acute loss of CTCF, cohesin, WAPL or YY1
  JOURNAL   Nat Genet 54 (12), 1919-1932 (2022)
   PUBMED   36471071
  REMARK    GeneRIF: Enhancer-promoter interactions and transcription are
            largely maintained upon acute loss of CTCF, cohesin, WAPL or YY1.
REFERENCE   6  (residues 1 to 733)
  AUTHORS   Farrell CM, West AG and Felsenfeld G.
  TITLE     Conserved CTCF insulator elements flank the mouse and human
            beta-globin loci
  JOURNAL   Mol Cell Biol 22 (11), 3820-3831 (2002)
   PUBMED   11997516
  REMARK    GeneRIF: Conserved CTCF insulator elements flank the mouse and
            human beta-globin loci.
REFERENCE   7  (residues 1 to 733)
  AUTHORS   Burke LJ, Hollemann T, Pieler T and Renkawitz R.
  TITLE     Molecular cloning and expression of the chromatin insulator protein
            CTCF in Xenopus laevis
  JOURNAL   Mech Dev 113 (1), 95-98 (2002)
   PUBMED   11900981
REFERENCE   8  (residues 1 to 733)
  AUTHORS   Chao W, Huynh KD, Spencer RJ, Davidow LS and Lee JT.
  TITLE     CTCF, a candidate trans-acting factor for X-inactivation choice
  JOURNAL   Science 295 (5553), 345-347 (2002)
   PUBMED   11743158
  REMARK    GeneRIF: It's proposed that Tsix and CTCF together establish a
            regulatable epigenetic switch for X-inactivation.
REFERENCE   9  (residues 1 to 733)
  AUTHORS   Lutz M, Burke LJ, Barreto G, Goeman F, Greb H, Arnold R,
            Schultheiss H, Brehm A, Kouzarides T, Lobanenkov V and Renkawitz R.
  TITLE     Transcriptional repression by the insulator protein CTCF involves
            histone deacetylases
  JOURNAL   Nucleic Acids Res 28 (8), 1707-1713 (2000)
   PUBMED   10734189
REFERENCE   10 (residues 1 to 733)
  AUTHORS   Filippova GN, Fagerlie S, Klenova EM, Myers C, Dehner Y, Goodwin G,
            Neiman PE, Collins SJ and Lobanenkov VV.
  TITLE     An exceptionally conserved transcriptional repressor, CTCF, employs
            different combinations of zinc fingers to bind diverged promoter
            sequences of avian and mammalian c-myc oncogenes
  JOURNAL   Mol Cell Biol 16 (6), 2802-2813 (1996)
   PUBMED   8649389
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127419.3 and AC152826.2.
            
            On Apr 4, 2022 this sequence version replaced XP_036009641.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422597.1196548.1,
                                           SRR13422600.331383.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..733
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.04 cM"
     Protein         1..733
                     /product="transcriptional repressor CTCF isoform 4"
                     /note="transcriptional repressor CTCF; CTCFL paralog;
                     11-zinc finger protein"
                     /calculated_mol_wt=83313
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          180..211
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61164.2)"
     Region          266..289
                     /region_name="zf-H2C2_5"
                     /note="C2H2-type zinc-finger domain; pfam13909"
                     /db_xref="CDD:404746"
     Region          268..288
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(273,275,277,279..280,283..284,287,301,303,307..308,
                     311..312,315,329,331,333,335..336,339..340,346)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          280..305
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:433230"
     Site            289
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          296..316
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          309..333
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:433230"
     Site            317
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          324..347
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          351..375
                     /region_name="zf-H2C2_5"
                     /note="C2H2-type zinc-finger domain; pfam13909"
                     /db_xref="CDD:404746"
     Region          353..373
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          <366..500
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Site            374
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          381..401
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            402
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          409..426
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          439..457
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          469..489
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(474,476,478,480..481,484..485,488,502,504,508..509,
                     512..513,516,530,532,534,536..537,540..541,545)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          497..517
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          509..534
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:433230"
     Region          525..546
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          557..573
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            609
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Site            610
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Site            612
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          696..723
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61164.2)"
     CDS             1..733
                     /gene="Ctcf"
                     /coded_by="NM_001403731.1:327..2528"
                     /note="isoform 4 is encoded by transcript variant 11"
                     /db_xref="GeneID:13018"
                     /db_xref="MGI:MGI:109447"
ORIGIN      
        1 megeaveaiv eesetfikgk erktyqrrre ggqeedachl pqnqtdggev vqdvnssvqm
       61 vmmeqldptl lqmktevmeg tvapeaeaav ddtqiitlqv vnmeeqpini gelqlvqvpv
      121 pvtvpvatts veelqgayen evskeglaes epmichtlpl pegfqvvkvg angevetleq
      181 gelppqedss wqkdpdyqpp akktkktkks klryteegkd vdvsvydfee eqqegllsev
      241 naekvvgnmk ppkptkikkk gvkktfqcel csytcprrsn ldrhmkshtd erphkchlcg
      301 rafrtvtllr nhlnthtgtr phkcpdcdma fvtsgelvrh rrykhthekp fkcsmcdyas
      361 vevsklkrhi rshtgerpfq cslcsyasrd tyklkrhmrt hsgekpyecy icharftqsg
      421 tmkmhilqkh tenvakfhcp hcdtviarks dlgvhlrkqh syieqgkkcr ycdavfhery
      481 aliqhqkshk nekrfkcdqc dyacrqerhm imhkrthtge kpyacshcdk tfrqkqlldm
      541 hfkryhdpnf vpaafvcskc gktftrrntm arhadncagp dgvegengge tkkskrgrkr
      601 kmrskkedss dsenaepdld dneeeeepav eiepepepqp qpppppqpva papppakkrr
      661 grppgrtnqp kqnqpiiqve dqntgaieni ivevkkepda epaegeeeea qaattdapng
      721 dltpemilsm mdr
//
LOCUS       NP_001075036             464 aa            linear   ROD 09-OCT-2023
DEFINITION  mitogen-activated protein kinase 10 isoform 1 [Mus musculus].
ACCESSION   NP_001075036
VERSION     NP_001075036.1
DBSOURCE    REFSEQ: accession NM_001081567.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 464)
  AUTHORS   Priego M, Noriega L, Kalinin S, Hoffman LM, Feinstein DL and
            Morfini G.
  TITLE     Genetic deletion of c-Jun amino-terminal kinase 3 (JNK3) modestly
            increases disease severity in a mouse model of multiple sclerosis
  JOURNAL   J Neuroimmunol 382, 578152 (2023)
   PUBMED   37454525
  REMARK    GeneRIF: Genetic deletion of c-Jun amino-terminal kinase 3 (JNK3)
            modestly increases disease severity in a mouse model of multiple
            sclerosis.
REFERENCE   2  (residues 1 to 464)
  AUTHORS   Liu F, Deng Y, Zhao Y, Li Z, Gao J, Zhang Y, Yang X, Liu Y and Xia
            Y.
  TITLE     Time series RNA-seq analysis identifies MAPK10 as a critical gene
            in diabetes mellitus-induced atrial fibrillation in mice
  JOURNAL   J Mol Cell Cardiol 168, 70-82 (2022)
   PUBMED   35489387
  REMARK    GeneRIF: Time series RNA-seq analysis identifies MAPK10 as a
            critical gene in diabetes mellitus-induced atrial fibrillation in
            mice.
REFERENCE   3  (residues 1 to 464)
  AUTHORS   Cunningham JG, Scripter JD, Nti SA and Tucker ES.
  TITLE     Early construction of the thalamocortical axon pathway requires
            c-Jun N-terminal kinase signaling within the ventral forebrain
  JOURNAL   Dev Dyn 251 (3), 459-480 (2022)
   PUBMED   34494344
REFERENCE   4  (residues 1 to 464)
  AUTHORS   Goodwani S, Fernandez C, Acton PJ, Buggia-Prevot V, McReynolds ML,
            Ma J, Hu CH, Hamby ME, Jiang Y, Le K, Soth MJ, Jones P and Ray WJ.
  TITLE     Dual Leucine Zipper Kinase Is Constitutively Active in the Adult
            Mouse Brain and Has Both Stress-Induced and Homeostatic Functions
  JOURNAL   Int J Mol Sci 21 (14), 4849 (2020)
   PUBMED   32659913
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 464)
  AUTHORS   Loughran G, Chou MY, Ivanov IP, Jungreis I, Kellis M, Kiran AM,
            Baranov PV and Atkins JF.
  TITLE     Evidence of efficient stop codon readthrough in four mammalian
            genes
  JOURNAL   Nucleic Acids Res 42 (14), 8928-8938 (2014)
   PUBMED   25013167
REFERENCE   6  (residues 1 to 464)
  AUTHORS   Beier H and Grimm M.
  TITLE     Misreading of termination codons in eukaryotes by natural nonsense
            suppressor tRNAs
  JOURNAL   Nucleic Acids Res 29 (23), 4767-4782 (2001)
   PUBMED   11726686
  REMARK    Review article
REFERENCE   7  (residues 1 to 464)
  AUTHORS   Yang DD, Kuan CY, Whitmarsh AJ, Rincon M, Zheng TS, Davis RJ, Rakic
            P and Flavell RA.
  TITLE     Absence of excitotoxicity-induced apoptosis in the hippocampus of
            mice lacking the Jnk3 gene
  JOURNAL   Nature 389 (6653), 865-870 (1997)
   PUBMED   9349820
REFERENCE   8  (residues 1 to 464)
  AUTHORS   Casanova E, Garate C, Ovalle S, Calvo P and Chinchetru MA.
  TITLE     Identification of four splice variants of the mouse
            stress-activated protein kinase JNK/SAPK alpha-isoform
  JOURNAL   Neuroreport 7 (7), 1320-1324 (1996)
   PUBMED   8817558
REFERENCE   9  (residues 1 to 464)
  AUTHORS   Martin JH, Mohit AA and Miller CA.
  TITLE     Developmental expression in the mouse nervous system of the p493F12
            SAP kinase
  JOURNAL   Brain Res Mol Brain Res 35 (1-2), 47-57 (1996)
   PUBMED   8717339
REFERENCE   10 (residues 1 to 464)
  AUTHORS   Suzuki J, Yoshida S, Chen ZL, Momota Y, Kato K, Hirata A and
            Shiosaka S.
  TITLE     Ontogeny of neuropsin mRNA expression in the mouse brain
  JOURNAL   Neurosci Res 23 (4), 345-351 (1995)
   PUBMED   8602273
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC160244.11, AC123664.15,
            AC137121.9 and AC125252.7.
            
            Summary: The protein encoded by this gene is a member of the MAP
            kinase family. MAP kinases act as integration points for multiple
            biochemical signals, and thus are involved in a wide variety of
            cellular processes, such as proliferation, differentiation,
            transcription regulation and development. This kinase is
            specifically expressed in a subset of neurons in the nervous system
            and is activated by threonine and tyrosine phosphorylation.
            Targeted deletion of this gene in mice suggests that it may have a
            role in stress-induced neuronal apoptosis. Alternatively spliced
            transcript variants encoding different isoforms have been found for
            this gene. A recent study provided evidence for translational
            readthrough in this gene, and expression of an additional
            C-terminally extended isoform via the use of an alternative
            in-frame translation termination codon. [provided by RefSeq, Dec
            2017].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript and encodes two isoforms, which result from the use of
            alternative in-frame translation termination codons. The shorter
            isoform (1, also know as JNK3 alpha2) results from translation
            termination at the upstream UGA stop codon, while the longer
            isoform (1x) results from UGA stop codon readthrough to the
            downstream UGA termination codon. This RefSeq represents the
            shorter isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219379.4978.1, BC046625.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..464
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 49.61 cM"
     Protein         1..464
                     /product="mitogen-activated protein kinase 10 isoform 1"
                     /EC_number="2.7.11.24"
                     /note="JNK3 beta1 protein kinase; JNK3 beta2 protein
                     kinase; MAP kinase 10; MAP kinase p49 3F12; c-Jun
                     N-terminal kinase 3; stress-activated protein kinase JNK3;
                     SAPK/Erk/kinase 2"
                     /calculated_mol_wt=52387
     Region          63..398
                     /region_name="STKc_JNK"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     c-Jun N-terminal Kinase; cd07850"
                     /db_xref="CDD:270840"
     Site            order(70..76,78,91,93,110,124,146..152,154..155,189,191,
                     193..194,196,206..207,210,221,223..226,228,265)
                     /site_type="active"
                     /db_xref="CDD:270840"
     Site            order(70..76,78,91,93,124,146..152,196,206)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270840"
     Site            order(110,154,189,191,210,221,223..226,228,265)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270840"
     Site            order(150,156,165,168,197..201,361..362,364,367)
                     /site_type="other"
                     /note="KIM docking site [polypeptide binding]"
                     /db_xref="CDD:270840"
     Site            order(206..216,220..228)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270840"
     Region          221..223
                     /region_name="TXY"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61831.2)"
     Site            221
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by MAP2K7.
                     /evidence=ECO:0000250|UniProtKB:P53779; propagated from
                     UniProtKB/Swiss-Prot (Q61831.2)"
     Site            223
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by MAP2K4.
                     /evidence=ECO:0000250|UniProtKB:P53779; propagated from
                     UniProtKB/Swiss-Prot (Q61831.2)"
     Region          405..464
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61831.2)"
     CDS             1..464
                     /gene="Mapk10"
                     /gene_synonym="C230008H04Rik; JNK3; JNK3B1; JNK3B2;
                     p493F12; p54bSAPK; SAPK(beta); Serk2"
                     /coded_by="NM_001081567.3:517..1911"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS39185.1"
                     /db_xref="GeneID:26414"
                     /db_xref="MGI:MGI:1346863"
ORIGIN      
        1 mslhflyycs eptldvkiaf cqgfdkhvdv ssiakhynms kskvdnqfys vevgdstftv
       61 lkryqnlkpi gsgaqgivca aydavldrnv aikklsrpfq nqthakrayr elvlmkcvnh
      121 kniisllnvf tpqktleefq dvylvmelmd anlcqviqme ldhermsyll yqmlcgikhl
      181 hsagiihrdl kpsnivvksd ctlkildfgl artagtsfmm tpyvvtryyr apevilgmgy
      241 kenvdiwsvg cimgemvrhk ilfpgrdyid qwnkvieqlg tpcpefmkkl qptvrnyven
      301 rpkyagltfp klfpdslfpa dsehnklkas qardllskml vidpakrisv ddalqhpyin
      361 vwydpaevea pppqiydkql derehtieew keliykevmn seektkngvv kgqpspsgaa
      421 vnsseslpps ssvndissms tdqtlasdtd ssleasagpl gccr
//
LOCUS       NP_001397155             519 aa            linear   ROD 09-OCT-2023
DEFINITION  nuclear respiratory factor 1 isoform e [Mus musculus].
ACCESSION   NP_001397155
VERSION     NP_001397155.1
DBSOURCE    REFSEQ: accession NM_001410226.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 519)
  AUTHORS   Cheng C, Tian Y, Yang R, Guo W, Xiao K, Zhang F, Tian J, Deng Z,
            Yang W, Yang H and Zhou Z.
  TITLE     miR-5581 Contributes to Osteoarthritis by Targeting NRF1 to Disturb
            the Proliferation and Functions of Chondrocytes
  JOURNAL   Am J Pathol 193 (9), 1234-1247 (2023)
   PUBMED   37611970
  REMARK    GeneRIF: miR-5581 Contributes to Osteoarthritis by Targeting NRF1
            to Disturb the Proliferation and Functions of Chondrocytes.
REFERENCE   2  (residues 1 to 519)
  AUTHORS   Meng Z, Liang B, Wu Y, Liu C, Wang H, Du Y, Gan L, Gao E, Lau WB,
            Christopher TA, Lopez BL, Koch WJ, Ma X, Zhao F, Wang Y and Zhao J.
  TITLE     Hypoadiponectinemia-induced upregulation of microRNA449b
            downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury
            in diabetic mice
  JOURNAL   J Mol Cell Cardiol 182, 1-14 (2023)
   PUBMED   37437402
  REMARK    GeneRIF: Hypoadiponectinemia-induced upregulation of microRNA449b
            downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury
            in diabetic mice.
REFERENCE   3  (residues 1 to 519)
  AUTHORS   Zhao T, Zhang J, Lei H, Meng Y, Cheng H, Zhao Y, Geng G, Mu C, Chen
            L, Liu Q, Luo Q, Zhang C, Long Y, Su J, Wang Y, Li Z, Sun J, Chen
            G, Li Y, Liao X, Shang Y, Hu G, Chen Q and Zhu Y.
  TITLE     NRF1-mediated mitochondrial biogenesis antagonizes innate antiviral
            immunity
  JOURNAL   EMBO J 42 (16), e113258 (2023)
   PUBMED   37409632
  REMARK    GeneRIF: NRF1-mediated mitochondrial biogenesis antagonizes innate
            antiviral immunity.
REFERENCE   4  (residues 1 to 519)
  AUTHORS   Akl MG, Baccetto R, Stebbings BM, Li L and Widenmaier SB.
  TITLE     Euglycemia is affected by stress defense factor hepatocyte NRF1,
            but not NRF2
  JOURNAL   Biochem Biophys Res Commun 668, 96-103 (2023)
   PUBMED   37245295
  REMARK    GeneRIF: Euglycemia is affected by stress defense factor hepatocyte
            NRF1, but not NRF2.
REFERENCE   5  (residues 1 to 519)
  AUTHORS   Akl MG, Li L, Baccetto R, Phanse S, Zhang Q, Trites MJ, McDonald S,
            Aoki H, Babu M and Widenmaier SB.
  TITLE     Complementary gene regulation by NRF1 and NRF2 protects against
            hepatic cholesterol overload
  JOURNAL   Cell Rep 42 (4), 112399 (2023)
   PUBMED   37060561
  REMARK    GeneRIF: Complementary gene regulation by NRF1 and NRF2 protects
            against hepatic cholesterol overload.
            Erratum:[Cell Rep. 2023 Jul 25;42(7):112872. PMID: 37454293]
REFERENCE   6  (residues 1 to 519)
  AUTHORS   Carmona MC, Iglesias R, Obregon MJ, Darlington GJ, Villarroya F and
            Giralt M.
  TITLE     Mitochondrial biogenesis and thyroid status maturation in brown fat
            require CCAAT/enhancer-binding protein alpha
  JOURNAL   J Biol Chem 277 (24), 21489-21498 (2002)
   PUBMED   11940593
REFERENCE   7  (residues 1 to 519)
  AUTHORS   Huo L and Scarpulla RC.
  TITLE     Mitochondrial DNA instability and peri-implantation lethality
            associated with targeted disruption of nuclear respiratory factor 1
            in mice
  JOURNAL   Mol Cell Biol 21 (2), 644-654 (2001)
   PUBMED   11134350
REFERENCE   8  (residues 1 to 519)
  AUTHORS   Schaefer L, Engman H and Miller JB.
  TITLE     Coding sequence, chromosomal localization, and expression pattern
            of Nrf1: the mouse homolog of Drosophila erect wing
  JOURNAL   Mamm Genome 11 (2), 104-110 (2000)
   PUBMED   10656923
REFERENCE   9  (residues 1 to 519)
  AUTHORS   Huo L and Scarpulla RC.
  TITLE     Multiple 5'-untranslated exons in the nuclear respiratory factor 1
            gene span 47 kb and contribute to transcript heterogeneity and
            translational efficiency
  JOURNAL   Gene 233 (1-2), 213-224 (1999)
   PUBMED   10375638
REFERENCE   10 (residues 1 to 519)
  AUTHORS   Virbasius CA, Virbasius JV and Scarpulla RC.
  TITLE     NRF-1, an activator involved in nuclear-mitochondrial interactions,
            utilizes a new DNA-binding domain conserved in a family of
            developmental regulators
  JOURNAL   Genes Dev 7 (12A), 2431-2445 (1993)
   PUBMED   8253388
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134897.4 and AC153632.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422598.1223890.1,
                                           SRR17253011.2953197.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..519
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 12.47 cM"
     Protein         1..519
                     /product="nuclear respiratory factor 1 isoform e"
                     /note="NRF-1; alpha-pal; alpha palindromic-binding
                     protein"
                     /calculated_mol_wt=55677
     Region          1..78
                     /region_name="Dimerization. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU00.2)"
     Region          36..57
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU00.2)"
     Site            39
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:Q16656; propagated from
                     UniProtKB/Swiss-Prot (Q9WU00.2)"
     Site            44
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:Q16656; propagated from
                     UniProtKB/Swiss-Prot (Q9WU00.2)"
     Site            46
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:Q16656; propagated from
                     UniProtKB/Swiss-Prot (Q9WU00.2)"
     Site            47
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:Q16656; propagated from
                     UniProtKB/Swiss-Prot (Q9WU00.2)"
     Site            52
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:Q16656; propagated from
                     UniProtKB/Swiss-Prot (Q9WU00.2)"
     Region          87..283
                     /region_name="Nrf1_DNA-bind"
                     /note="NLS-binding and DNA-binding and dimerization
                     domains of Nrf1; pfam10491"
                     /db_xref="CDD:402218"
     Region          88..116
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU00.2)"
     CDS             1..519
                     /gene="Nrf1"
                     /gene_synonym="D6Ertd415e"
                     /coded_by="NM_001410226.1:274..1833"
                     /note="isoform e is encoded by transcript variant 16"
                     /db_xref="GeneID:18181"
                     /db_xref="MGI:MGI:1332235"
ORIGIN      
        1 meehgvtqte hmatieahav aqqvqqvhva tytehsmlsa dedspssped tsyddsdiln
       61 staadevtah laaagpvgma aaaavatgkk rkrphvfesn psirkrqqtr llrklratld
      121 eyttrvgqqa ivlcispskp npvfkvfgaa plenvvrkyk smiledlesa laehapapqe
      181 vnselpplti dgipvsvdkm tqaqlrafip emlkystgrg kpgwgkesck piwwpedipw
      241 anvrsdvrte eqkqrvswtq alrtivkncy kqhgredlly afedqqtqtq attthsiahl
      301 vpsqtvvqtf snpdgtvsli qvgtgatvat ladaselptt vtvaqvnysa vadgeveqnw
      361 atlqggemti qttqaseatq avaslaeaav aasqemqqga tvtmalnsea aahavatlae
      421 atlqgggqiv lsgetaaavg altgvqdang lgspvlpeim asktrgyrhs cgrdlyrlfs
      481 ffllysknne rillapatsg spcfyvrnii tirvgilss
//
LOCUS       NP_001341977             509 aa            linear   ROD 09-OCT-2023
DEFINITION  activin receptor type-1 precursor [Mus musculus].
ACCESSION   NP_001341977 XP_017170495
VERSION     NP_001341977.1
DBSOURCE    REFSEQ: accession NM_001355048.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 509)
  AUTHORS   Yang YS, Lin C, Ma H, Xie J, Kaplan FS, Gao G and Shim JH.
  TITLE     AAV-Mediated Targeting of the Activin A-ACVR1R206H Signaling in
            Fibrodysplasia Ossificans Progressiva
  JOURNAL   Biomolecules 13 (9), 1364 (2023)
   PUBMED   37759764
  REMARK    GeneRIF: AAV-Mediated Targeting of the Activin A-ACVR1[R206H]
            Signaling in Fibrodysplasia Ossificans Progressiva.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 509)
  AUTHORS   Yamaguchi H, Shen J, Little DR, Li M, Sozen S, Suzuki K, Mishina Y
            and Komatsu Y.
  TITLE     Enhanced BMP signaling through ALK2 attenuates keratinocyte
            differentiation
  JOURNAL   Biochem Biophys Res Commun 629, 101-105 (2022)
   PUBMED   36116371
  REMARK    GeneRIF: Enhanced BMP signaling through ALK2 attenuates
            keratinocyte differentiation.
REFERENCE   3  (residues 1 to 509)
  AUTHORS   Yamamoto M, Stoessel SJ, Yamamoto S and Goldhamer DJ.
  TITLE     Overexpression of Wild-Type ACVR1 in Fibrodysplasia Ossificans
            Progressiva Mice Rescues Perinatal Lethality and Inhibits
            Heterotopic Ossification
  JOURNAL   J Bone Miner Res 37 (11), 2077-2093 (2022)
   PUBMED   35637634
  REMARK    GeneRIF: Overexpression of Wild-Type ACVR1 in Fibrodysplasia
            Ossificans Progressiva Mice Rescues Perinatal Lethality and
            Inhibits Heterotopic Ossification.
REFERENCE   4  (residues 1 to 509)
  AUTHORS   Lees-Shepard JB, Stoessel SJ, Chandler JT, Bouchard K, Bento P,
            Apuzzo LN, Devarakonda PM, Hunter JW and Goldhamer DJ.
  TITLE     An anti-ACVR1 antibody exacerbates heterotopic ossification by
            fibro-adipogenic progenitors in fibrodysplasia ossificans
            progressiva mice
  JOURNAL   J Clin Invest 132 (12) (2022)
   PUBMED   35503416
REFERENCE   5  (residues 1 to 509)
  AUTHORS   Chen HY, Hu Y, Xu XB, Zhou YA, Li NS, He C, Xie C, Lu NH and Zhu Y.
  TITLE     Upregulation of oncogene Activin A receptor type I by Helicobacter
            pylori infection promotes gastric intestinal metaplasia via
            regulating CDX2
  JOURNAL   Helicobacter 26 (6), e12849 (2021)
   PUBMED   34490965
  REMARK    GeneRIF: Upregulation of oncogene Activin A receptor type I by
            Helicobacter pylori infection promotes gastric intestinal
            metaplasia via regulating CDX2.
REFERENCE   6  (residues 1 to 509)
  AUTHORS   Schmitt J, Mielke R and Schrewe H.
  TITLE     Genomic organization of a mouse type I activin receptor
  JOURNAL   Biochem Biophys Res Commun 213 (1), 211-217 (1995)
   PUBMED   7639738
REFERENCE   7  (residues 1 to 509)
  AUTHORS   Verschueren K, Dewulf N, Goumans MJ, Lonnoy O, Feijen A, Grimsby S,
            Vandi Spiegle K, ten Dijke P, Moren A, Vanscheeuwijck P, Heldin CH,
            Miyazono K, Mummery C, Van Den Eijnden-Van Raaij J and Huylebroeck
            D.
  TITLE     Expression of type I and type IB receptors for activin in
            midgestation mouse embryos suggests distinct functions in
            organogenesis
  JOURNAL   Mech Dev 52 (1), 109-123 (1995)
   PUBMED   7577669
REFERENCE   8  (residues 1 to 509)
  AUTHORS   Roelen BA, Lin HY, Knezevic V, Freund E and Mummery CL.
  TITLE     Expression of TGF-beta s and their receptors during implantation
            and organogenesis of the mouse embryo
  JOURNAL   Dev Biol 166 (2), 716-728 (1994)
   PUBMED   7813789
REFERENCE   9  (residues 1 to 509)
  AUTHORS   Nakamura T, Sugino K, Kurosawa N, Sawai M, Takio K, Eto Y, Iwashita
            S, Muramatsu M, Titani K and Sugino H.
  TITLE     Isolation and characterization of activin receptor from mouse
            embryonal carcinoma cells. Identification of its
            serine/threonine/tyrosine protein kinase activity
  JOURNAL   J Biol Chem 267 (26), 18924-18928 (1992)
   PUBMED   1326537
REFERENCE   10 (residues 1 to 509)
  AUTHORS   Mathews LS and Vale WW.
  TITLE     Expression cloning of an activin receptor, a predicted
            transmembrane serine kinase
  JOURNAL   Cell 65 (6), 973-982 (1991)
   PUBMED   1646080
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732468.10 and AL807788.9.
            
            On Sep 6, 2017 this sequence version replaced XP_017170495.1.
            
            Transcript Variant: This variant (4) differs in the 5' UTR compared
            to variant 1. All five variants encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.271415.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 33.05 cM"
     Protein         1..509
                     /product="activin receptor type-1 precursor"
                     /EC_number="2.7.11.30"
                     /note="activin receptor type-1; TSR-I; TSK-7L; activin
                     receptor type I; TGF-B superfamily receptor type I;
                     serine/threonine-protein kinase receptor R1"
                     /calculated_mol_wt=55077
     sig_peptide     1..20
                     /note="/evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (P37172.2)"
                     /calculated_mol_wt=2167
     mat_peptide     21..509
                     /product="Activin receptor type-1. /id=PRO_0000024395"
                     /note="propagated from UniProtKB/Swiss-Prot (P37172.2)"
                     /calculated_mol_wt=55077
     Region          33..103
                     /region_name="Activin_recp"
                     /note="Activin types I and II receptor domain; pfam01064"
                     /db_xref="CDD:426025"
     Site            102
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P37172.2)"
     Site            124..146
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P37172.2)"
     Region          179..206
                     /region_name="TGF_beta_GS"
                     /note="Transforming growth factor beta type I GS-motif;
                     pfam08515"
                     /db_xref="CDD:430045"
     Region          202..499
                     /region_name="STKc_ACVR1_ALK1"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     Activin Type I Receptor and Activin receptor-Like Kinase
                     1; cd14142"
                     /db_xref="CDD:271044"
     Site            order(202..203,206..207,245..246,249..250,253..254,268,
                     270)
                     /site_type="other"
                     /note="FKBP12 binding site [polypeptide binding]"
                     /db_xref="CDD:271044"
     Site            order(214..218,222,233,235,263,283..286,290,292,336,338,
                     340..341,343,354,357,377..380)
                     /site_type="active"
                     /db_xref="CDD:271044"
     Site            order(214..220,222,233,235,283..284,286,290,340..341,343,
                     354)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271044"
     Site            order(218,290,292,336,338,340,357,377..380)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:271044"
     Site            353..380
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:271044"
     Site            501
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04771; propagated from
                     UniProtKB/Swiss-Prot (P37172.2)"
     CDS             1..509
                     /gene="Acvr1"
                     /gene_synonym="ActR-I; ActRIA; Acvr; Acvr1a; Acvrlk2;
                     Alk-2; ALK2; Alk8; D330013D15Rik; SKR1; Tsk7L"
                     /coded_by="NM_001355048.1:238..1767"
                     /db_xref="CCDS:CCDS16050.1"
                     /db_xref="GeneID:11477"
                     /db_xref="MGI:MGI:87911"
ORIGIN      
        1 mvdgvmilpv lmmmafpsps vedekpkvnq klymcvcegl scgnedhceg qqcfsslsin
       61 dgfhvyqkgc fqvyeqgkmt cktppspgqa veccqgdwcn rnitaqlptk gksfpgtqnf
      121 hlevgliils vvfavcllac ilgvalrkfk rrnqerlnpr dveygtiegl ittnvgdstl
      181 aelldhscts gsgsglpflv qrtvarqitl lecvgkgryg evwrgswqge nvavkifssr
      241 dekswfrete lyntvmlrhe nilgfiasdm tsrhsstqlw lithyhemgs lydylqlttl
      301 dtvsclrivl siasglahlh ieifgtqgks aiahrdlksk nilvkkngqc ciadlglavm
      361 hsqstnqldv gnnprvgtkr ymapevldet iqvdcfdsyk rvdiwafglv lwevarrmvs
      421 ngivedykpp fydvvpndps fedmrkvvcv dqqrpnipnr wfsdptltsl aklmkecwyq
      481 npsarltalr ikktltkidn sldklktdc
//
LOCUS       NP_001298000             249 aa            linear   ROD 09-OCT-2023
DEFINITION  methyl-CpG-binding domain protein 2 isoform 2 [Mus musculus].
ACCESSION   NP_001298000 XP_006525775
VERSION     NP_001298000.1
DBSOURCE    REFSEQ: accession NM_001311071.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 249)
  AUTHORS   Duan W, Huang J, Wasti B, Chen Z, Yuan Y, He Y, Li D, Jia J, Liu S,
            Liu Y, Ma L, Zeng Q, Zhu L, Li J, Zhang X and Xiang X.
  TITLE     miR-146a-3p as a potential novel therapeutic by targeting MBD2 to
            mediate Th17 differentiation in Th17 predominant neutrophilic
            severe asthma
  JOURNAL   Clin Exp Med 23 (6), 2839-2854 (2023)
   PUBMED   36961677
  REMARK    GeneRIF: miR-146a-3p as a potential novel therapeutic by targeting
            MBD2 to mediate Th17 differentiation in Th17 predominant
            neutrophilic severe asthma.
REFERENCE   2  (residues 1 to 249)
  AUTHORS   Lax E, Do Carmo S, Enuka Y, Sapozhnikov DM, Welikovitch LA, Mahmood
            N, Rabbani SA, Wang L, Britt JP, Hancock WW, Yarden Y and Szyf M.
  TITLE     Methyl-CpG binding domain 2 (Mbd2) is an epigenetic regulator of
            autism-risk genes and cognition
  JOURNAL   Transl Psychiatry 13 (1), 259 (2023)
   PUBMED   37443311
  REMARK    GeneRIF: Methyl-CpG binding domain 2 (Mbd2) is an epigenetic
            regulator of autism-risk genes and cognition.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 249)
  AUTHORS   Jiang Y, Li L, Pan Q, Du X, Han Q, Ling F, Li R, Mai L, Huang J,
            Chu S and Ma L.
  TITLE     Methyl-cpg-binding Domain Protein 2 Silencing Inhibits Th17
            Differentiation of CD4+T cells Induced by Ovalbumin
  JOURNAL   Iran J Immunol 20 (1), 45-56 (2023)
   PUBMED   36932919
  REMARK    GeneRIF: Methyl-cpg-binding Domain Protein 2 Silencing Inhibits
            Th17 Differentiation of CD4+T cells Induced by Ovalbumin.
REFERENCE   4  (residues 1 to 249)
  AUTHORS   Wu GR, Zhou M, Wang Y, Zhou Q, Zhang L, He L, Zhang S, Yu Q, Xu Y,
            Zhao J, Xiong W and Wang CY.
  TITLE     Blockade of Mbd2 by siRNA-loaded liposomes protects mice against
            OVA-induced allergic airway inflammation via repressing M2
            macrophage production
  JOURNAL   Front Immunol 13, 930103 (2022)
   PUBMED   36090987
  REMARK    GeneRIF: Blockade of Mbd2 by siRNA-loaded liposomes protects mice
            against OVA-induced allergic airway inflammation via repressing M2
            macrophage production.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 249)
  AUTHORS   Ai K, Pan J, Zhang P, Li H, He Z, Zhang H, Li X, Li Y, Yi L, Kang
            Y, Wang Y, Xiang X, Chai X and Zhang D.
  TITLE     Methyl-CpG-binding domain protein 2 contributes to renal fibrosis
            through promoting polarized M1 macrophages
  JOURNAL   Cell Death Dis 13 (2), 125 (2022)
   PUBMED   35136032
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 249)
  AUTHORS   Klinowska TC, Alexander CM, Georges-Labouesse E, Van der Neut R,
            Kreidberg JA, Jones CJ, Sonnenberg A and Streuli CH.
  TITLE     Epithelial development and differentiation in the mammary gland is
            not dependent on alpha 3 or alpha 6 integrin subunits
  JOURNAL   Dev Biol 233 (2), 449-467 (2001)
   PUBMED   11336507
REFERENCE   7  (residues 1 to 249)
  AUTHORS   Hendrich B, Guy J, Ramsahoye B, Wilson VA and Bird A.
  TITLE     Closely related proteins MBD2 and MBD3 play distinctive but
            interacting roles in mouse development
  JOURNAL   Genes Dev 15 (6), 710-723 (2001)
   PUBMED   11274056
REFERENCE   8  (residues 1 to 249)
  AUTHORS   Guy J, Hendrich B, Holmes M, Martin JE and Bird A.
  TITLE     A mouse Mecp2-null mutation causes neurological symptoms that mimic
            Rett syndrome
  JOURNAL   Nat Genet 27 (3), 322-326 (2001)
   PUBMED   11242117
REFERENCE   9  (residues 1 to 249)
  AUTHORS   Hendrich B, Abbott C, McQueen H, Chambers D, Cross S and Bird A.
  TITLE     Genomic structure and chromosomal mapping of the murine and human
            Mbd1, Mbd2, Mbd3, and Mbd4 genes
  JOURNAL   Mamm Genome 10 (9), 906-912 (1999)
   PUBMED   10441743
REFERENCE   10 (residues 1 to 249)
  AUTHORS   Hendrich B and Bird A.
  TITLE     Identification and characterization of a family of mammalian
            methyl-CpG binding proteins
  JOURNAL   Mol Cell Biol 18 (11), 6538-6547 (1998)
   PUBMED   9774669
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX239662.1, AF072245.1, AC134831.3 and BE953207.1.
            
            On Jul 21, 2015 this sequence version replaced XP_006525775.1.
            
            Transcript Variant: This variant (2) lacks part of the 3' coding
            region and uses an alternate 3'-terminal exon, compared to variant
            1. This results in a novel 3' coding region and 3' UTR, compared to
            variant 1. The encoded isoform (2) has a shorter and distinct
            C-terminus compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF072245.1, AK082825.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..249
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 44.54 cM"
     Protein         1..249
                     /product="methyl-CpG-binding domain protein 2 isoform 2"
                     /note="methyl-CpG-binding protein MBD2; testis-specific
                     methyl-CpG binding protein 2"
                     /calculated_mol_wt=25320
     Region          154..217
                     /region_name="MeCP2_MBD"
                     /note="MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a
                     protein family that share the methyl-CpG-binding domain
                     (MBD). The MBD, consists of about 70 residues and is
                     defined as the minimal region required for binding to
                     methylated DNA by a methyl-CpG-binding...; cd01396"
                     /db_xref="CDD:238690"
     Site            order(165,167,169,177,179,188,191,195)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238690"
     CDS             1..249
                     /gene="Mbd2"
                     /gene_synonym="MBD2a"
                     /coded_by="NM_001311071.1:126..875"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS79661.1"
                     /db_xref="GeneID:17191"
                     /db_xref="MGI:MGI:1333813"
ORIGIN      
        1 mrahpgggrc cpeqeegesa aggsgaggds aieqggqgsa lapspvsgvr regargggrg
       61 rgrwkqaarg ggvcgrgrgr grgrgrgrgr grgrgrpqsg gsglggdggg gaggcgggsg
      121 ggvaprrdpv pfpsgssgpg prgpratesg krmdcpalpp gwkkeevirk sglsagksdv
      181 yyfspsgkkf rskpqlaryl gnavdlssfd frtgkmmpsk lqknkqrlrn dplnqnkfrl
      241 ikkqtligl
//
LOCUS       NP_001157788             895 aa            linear   ROD 09-OCT-2023
DEFINITION  serine-rich coiled-coil domain-containing protein 1 [Mus musculus].
ACCESSION   NP_001157788
VERSION     NP_001157788.1
DBSOURCE    REFSEQ: accession NM_001164316.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 895)
  AUTHORS   Chen K, Chen X, Lang C, Yuan X, Huang J, Li Z, Xu M, Wu K, Zhou C,
            Li Q, Zhu C, Liu L and Shang X.
  TITLE     CircFam190a: a critical positive regulator of osteoclast
            differentiation via enhancement of the AKT1/HSP90beta complex
  JOURNAL   Exp Mol Med 55 (9), 2051-2066 (2023)
   PUBMED   37653038
  REMARK    GeneRIF: CircFam190a: a critical positive regulator of osteoclast
            differentiation via enhancement of the AKT1/HSP90beta complex.
REFERENCE   2  (residues 1 to 895)
  AUTHORS   Okazaki N, F-Kikuno R, Ohara R, Inamoto S, Koseki H, Hiraoka S,
            Saga Y, Seino S, Nishimura M, Kaisho T, Hoshino K, Kitamura H,
            Nagase T, Ohara O and Koga H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB646598.1, BB634602.1, AK031754.1 and AK173231.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164131,
                              SAMN01164132 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..895
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 29.24 cM"
     Protein         1..895
                     /product="serine-rich coiled-coil domain-containing
                     protein 1"
                     /note="protein FAM190A; family with sequence similarity
                     190, member A; coiled-coil serine-rich protein 1"
                     /calculated_mol_wt=98087
     Region          1..142
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C0C4.2)"
     Region          154..177
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C0C4.2)"
     Region          332..394
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C0C4.2)"
     Region          459..497
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C0C4.2)"
     Region          731..754
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C0C4.2)"
     CDS             1..895
                     /gene="Ccser1"
                     /gene_synonym="6230405M12Rik; C130092O11Rik; Fam190a"
                     /coded_by="NM_001164316.1:319..3006"
                     /db_xref="CCDS:CCDS51800.1"
                     /db_xref="GeneID:232035"
                     /db_xref="MGI:MGI:3045354"
ORIGIN      
        1 mgdsgsrrct lvsrlpifrk sinrrhdslp sspsssntag vhssspsstn sssgstgkrr
       61 sifrapsisf hhkkgsepkp epteqnlsis ngaqpshsnm qklsleehvk trgrhsvgfs
      121 ssrskkitrs ltedfereke pstnknvfin clssgrsegd dsgfteeqsr rsikqstkkl
      181 lpksfsshyk fcksvpqsqs tsliqqpefs laiaqyqeqe aalgrpspsc svdvterags
      241 slqspllsad lttaqtpsef laltedslse adafpksgst ashcdnfghn datsqptssl
      301 tavsktkmef vgtapcvmsp gryrlegrcs telhsspetp agnrrevslq stelsvgngs
      361 dpethlpahh qrgesplaha gepalrtgsp rtlgsydqhk alaerfkgvh pvsdsrvips
      421 sgdhvfnkts ygyeasaakv lasslspyre gryierrlrs ssegtagssr mvlkpkdghv
      481 easslrkhrt gsssskmnsl dvlnhlgsce ldeddlmldl efleeqnlqp pvcredschs
      541 vmsctavlls pvdpgkevnm leepkcpeps kqnlslritk dtdqearcsh vscmpnspsa
      601 dwpqqgveen ggidslpfrl mlqectavkt lllkmkrvlq esdvspssst tslpisplte
      661 eplpfkditr decsmlrlql kdrdelisql qaelekvqhl qkafasrvdk stqtellgcd
      721 glslkrleav qggretthrn rtmsqshstr drkaihtpte drfrystadq tspyknicql
      781 pglclsnflk dkelggvmkh trgnheavts emtqnsrttm gqsflkaaak peglpmfsek
      841 pkdpaalsrq hstftgrfgq pprgpislht ysrknvflhh nlhttefqtl gqqdg
//
LOCUS       NP_001343357              89 aa            linear   ROD 09-OCT-2023
DEFINITION  pancreatic progenitor cell differentiation and proliferation factor
            isoform b [Mus musculus].
ACCESSION   NP_001343357
VERSION     NP_001343357.1
DBSOURCE    REFSEQ: accession NM_001356428.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 89)
  AUTHORS   Wang YK, Ma N, Xu S, Huang JY, Ni QZ, Cao HJ, Zheng QW, Zhu B, Xia
            J, Zhang FK, Ding XF, Qiu XS, Chen TW, Wang K, Chen W, Li ZG, Cheng
            SQ, Xie D and Li JJ.
  TITLE     PPDPF suppresses the development of hepatocellular carcinoma
            through TRIM21-mediated ubiquitination of RIPK1
  JOURNAL   Cell Rep 42 (4), 112340 (2023)
   PUBMED   37027301
  REMARK    GeneRIF: PPDPF suppresses the development of hepatocellular
            carcinoma through TRIM21-mediated ubiquitination of RIPK1.
REFERENCE   2  (residues 1 to 89)
  AUTHORS   Ni QZ, Zhu B, Ji Y, Zheng QW, Liang X, Ma N, Jiang H, Zhang FK,
            Shang YR, Wang YK, Xu S, Zhang EB, Yuan YM, Chen TW, Yin FF, Cao
            HJ, Huang JY, Xia J, Ding XF, Qiu XS, Ding K, Song C, Zhou WT, Wu
            M, Wang K, Lui R, Lin Q, Chen W, Li ZG, Cheng SQ, Wang XF, Xie D
            and Li JJ.
  TITLE     PPDPF Promotes the Development of Mutant KRAS-Driven Pancreatic
            Ductal Adenocarcinoma by Regulating the GEF Activity of SOS1
  JOURNAL   Adv Sci (Weinh) 10 (2), e2202448 (2023)
   PUBMED   36453576
  REMARK    GeneRIF: PPDPF Promotes the Development of Mutant KRAS-Driven
            Pancreatic Ductal Adenocarcinoma by Regulating the GEF Activity of
            SOS1.
REFERENCE   3  (residues 1 to 89)
  AUTHORS   Zheng QW, Ni QZ, Zhu B, Liang X, Ma N, Wang YK, Xu S, Cao HJ, Xia
            J, Zhang FK, Zhang EB, Qiu XS, Ding XF, Qiu L, Zhang XL, Dong ZH,
            Li ZG, Zhang XL, Xie D and Li JJ.
  TITLE     PPDPF promotes lung adenocarcinoma progression via inhibiting
            apoptosis and NK cell-mediated cytotoxicity through STAT3
  JOURNAL   Oncogene 41 (36), 4244-4256 (2022)
   PUBMED   35906391
  REMARK    Erratum:[Oncogene. 2023 Aug;42(35):2655-2656. PMID: 37491607]
REFERENCE   4  (residues 1 to 89)
  AUTHORS   Ma N, Wang YK, Xu S, Ni QZ, Zheng QW, Zhu B, Cao HJ, Jiang H, Zhang
            FK, Yuan YM, Zhang EB, Chen TW, Xia J, Ding XF, Chen ZH, Zhang XP,
            Wang K, Cheng SQ, Qiu L, Li ZG, Yu YC, Wang XF, Zhou B, Li JJ and
            Xie D.
  TITLE     PPDPF alleviates hepatic steatosis through inhibition of mTOR
            signaling
  JOURNAL   Nat Commun 12 (1), 3059 (2021)
   PUBMED   34031390
  REMARK    GeneRIF: PPDPF alleviates hepatic steatosis through inhibition of
            mTOR signaling.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 89)
  AUTHORS   Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK,
            Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L,
            Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre
            JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A,
            Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ,
            Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall
            S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA,
            Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR,
            Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana
            S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, MacArthur DG,
            Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC,
            Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL,
            de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown
            SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bucan M and Murray
            SA.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. PMID: 29144450]
REFERENCE   6  (residues 1 to 89)
  AUTHORS   Lewandowski JP, Du F, Zhang S, Powell MB, Falkenstein KN, Ji H and
            Vokes SA.
  TITLE     Spatiotemporal regulation of GLI target genes in the mammalian limb
            bud
  JOURNAL   Dev Biol 406 (1), 92-103 (2015)
   PUBMED   26238476
REFERENCE   7  (residues 1 to 89)
  AUTHORS   Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H,
            Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T,
            Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P,
            Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ,
            Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD,
            Flicek P, Skarnes WC, Mallon AM and Parkinson H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL450341.10.
            
            Transcript Variant: This variant (3) lacks an alternate in-frame
            exon compared to variant 1. The resulting isoform (b) has the same
            N- and C-termini but is shorter compared to isoform a.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AV585998.1, SRR17253011.3849143.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..89
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 103.62 cM"
     Protein         1..89
                     /product="pancreatic progenitor cell differentiation and
                     proliferation factor isoform b"
                     /note="exocrine differentiation and proliferation factor"
                     /calculated_mol_wt=9706
     Region          1..85
                     /region_name="PPDFL"
                     /note="Differentiation and proliferation regulator;
                     pfam15060"
                     /db_xref="CDD:434428"
     CDS             1..89
                     /gene="Ppdpf"
                     /gene_synonym="0610012G23Rik; 2610317A05Rik;
                     2700038C09Rik; 3110053G12Rik"
                     /coded_by="NM_001356428.1:341..610"
                     /note="isoform b is encoded by transcript variant 3"
                     /db_xref="GeneID:66496"
                     /db_xref="MGI:MGI:1913746"
ORIGIN      
        1 maaipssgsl vathdyyrrl pkadpghwwa sfffgkstlp fmttvlespe rsaespqvsr
       61 spmtcgltpe tmkqqpvihs gqtnprdls
//
LOCUS       NP_001278106             706 aa            linear   ROD 09-OCT-2023
DEFINITION  nuclear factor of activated T-cells, cytoplasmic 2 isoform g [Mus
            musculus].
ACCESSION   NP_001278106 XP_006498955
VERSION     NP_001278106.1
DBSOURCE    REFSEQ: accession NM_001291177.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 706)
  AUTHORS   Fu Y, Wang J, Liu C, Liao K, Gao X, Tang R, Fan B, Hong Y, Xiao N,
            Xiao C and Liu WH.
  TITLE     Glycogen synthase kinase 3 controls T-cell exhaustion by regulating
            NFAT activation
  JOURNAL   Cell Mol Immunol 20 (10), 1127-1139 (2023)
   PUBMED   37553428
  REMARK    GeneRIF: Glycogen synthase kinase 3 controls T-cell exhaustion by
            regulating NFAT activation.
REFERENCE   2  (residues 1 to 706)
  AUTHORS   Wan X, Zhao S, Dai Y, Zhang J, Shen Y, Gong L and Le Q.
  TITLE     WNT16b promotes the proliferation and self-renewal of human limbal
            epithelial stem/progenitor cells via activating the
            calcium/calcineurin A/NFATC2 pathway
  JOURNAL   Cell Prolif 56 (10), e13460 (2023)
   PUBMED   36974338
  REMARK    GeneRIF: WNT16b promotes the proliferation and self-renewal of
            human limbal epithelial stem/progenitor cells via activating the
            calcium/calcineurin A/NFATC2 pathway.
REFERENCE   3  (residues 1 to 706)
  AUTHORS   Jiang F, Guo Y, Hu L, Zhang M, Meng J, Si Y and Shi H.
  TITLE     Role of nuclear factor of activated T Cells-1 in Sepsis-induced
            behavioral deficits in mice
  JOURNAL   Brain Res 1806, 148299 (2023)
   PUBMED   36842570
REFERENCE   4  (residues 1 to 706)
  AUTHORS   Nagai J, Lin J and Boyce JA.
  TITLE     Macrophage P2Y6 Receptor Signaling Selectively Activates NFATC2 and
            Suppresses Allergic Lung Inflammation
  JOURNAL   J Immunol 209 (12), 2293-2303 (2022)
   PUBMED   36307120
  REMARK    GeneRIF: Macrophage P2Y6 Receptor Signaling Selectively Activates
            NFATC2 and Suppresses Allergic Lung Inflammation.
REFERENCE   5  (residues 1 to 706)
  AUTHORS   Zhu L, Zhou X, Gu M, Kim J, Li Y, Ko CJ, Xie X, Gao T, Cheng X and
            Sun SC.
  TITLE     Dapl1 controls NFATc2 activation to regulate CD8+ T cell exhaustion
            and responses in chronic infection and cancer
  JOURNAL   Nat Cell Biol 24 (7), 1165-1176 (2022)
   PUBMED   35773432
REFERENCE   6  (residues 1 to 706)
  AUTHORS   Vihma H, Pruunsild P and Timmusk T.
  TITLE     Alternative splicing and expression of human and mouse NFAT genes
  JOURNAL   Genomics 92 (5), 279-291 (2008)
   PUBMED   18675896
REFERENCE   7  (residues 1 to 706)
  AUTHORS   Ho SN, Thomas DJ, Timmerman LA, Li X, Francke U and Crabtree GR.
  TITLE     NFATc3, a lymphoid-specific NFATc family member that is
            calcium-regulated and exhibits distinct DNA binding specificity
  JOURNAL   J Biol Chem 270 (34), 19898-19907 (1995)
   PUBMED   7650004
REFERENCE   8  (residues 1 to 706)
  AUTHORS   Jain J, Burgeon E, Badalian TM, Hogan PG and Rao A.
  TITLE     A similar DNA-binding motif in NFAT family proteins and the Rel
            homology region
  JOURNAL   J Biol Chem 270 (8), 4138-4145 (1995)
   PUBMED   7876165
REFERENCE   9  (residues 1 to 706)
  AUTHORS   Li X, Ho SN, Luna J, Giacalone J, Thomas DJ, Timmerman LA, Crabtree
            GR and Francke U.
  TITLE     Cloning and chromosomal localization of the human and murine genes
            for the T-cell transcription factors NFATc and NFATp
  JOURNAL   Cytogenet Cell Genet 68 (3-4), 185-191 (1995)
   PUBMED   7842733
REFERENCE   10 (residues 1 to 706)
  AUTHORS   Ho AM, Jain J, Rao A and Hogan PG.
  TITLE     Expression of the transcription factor NFATp in a neuronal cell
            line and in the murine nervous system
  JOURNAL   J Biol Chem 269 (45), 28181-28186 (1994)
   PUBMED   7961754
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK135414.1, EU887590.1, EU887581.1 and BP757417.1.
            
            On Mar 27, 2014 this sequence version replaced XP_006498955.1.
            
            Transcript Variant: This variant (14, also known as IB-IIS-deltaXa)
            contains alternate 5' exon structure, and it thus differs in the 5'
            UTR and initiates translation at a downstream in-frame start codon,
            compared to variant 1. The encoded isoform (g) is shorter at the
            N-terminus, compared to isoform a. Both variants 7 and 14 encode
            isoform g.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU887590.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..706
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 88.91 cM"
     Protein         1..706
                     /product="nuclear factor of activated T-cells, cytoplasmic
                     2 isoform g"
                     /note="nuclear factor of activated T-cells, cytoplasmic 2;
                     NFAT pre-existing subunit; T-cell transcription factor
                     NFAT1"
                     /calculated_mol_wt=76835
     Region          179..353
                     /region_name="RHD-n_NFAT"
                     /note="N-terminal sub-domain of the Rel homology domain
                     (RHD) of nuclear factor of activated T-cells (NFAT)
                     proteins; cd07881"
                     /db_xref="CDD:143641"
     Site            order(202,205,207..208,210..212,260,301,303..304,318..319,
                     321,352)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143641"
     Region          358..458
                     /region_name="IPT_NFAT"
                     /note="IPT domain of the NFAT family of transcription
                     factors. NFAT transcription complexes are a target of
                     calcineurin, a calcium dependent phosphatase, and activate
                     genes mainly involved in cell-cell-interaction; cd01178"
                     /db_xref="CDD:238583"
     Site            order(382,446)
                     /site_type="DNA binding"
                     /note="DNA binding sites [nucleotide binding]"
                     /db_xref="CDD:238583"
     CDS             1..706
                     /gene="Nfatc2"
                     /gene_synonym="NF-ATc2; NF-ATp; NFAT1; NFAT1-D; Nfatp"
                     /coded_by="NM_001291177.1:318..2438"
                     /note="isoform g is encoded by transcript variant 14"
                     /db_xref="GeneID:18019"
                     /db_xref="MGI:MGI:102463"
ORIGIN      
        1 msprtslaed sclgrhspvp rpasrssspg akrrhscaea lvaplpaasp qrsrspspqp
       61 sphvalqdds ipagypptag savlmdalnt latdspcgip skiwktspdp tpvstapska
      121 glarhiyptv eflgpceqee rrnsapesil lvpptwpkql vpaipicsip vtaslpplew
      181 plsnqsgsye lrievqpkph hrahyetegs rgavkaptgg hpvvqlhgym enkplglqif
      241 igtaderilk phafyqvhri tgktvtttsy ekivgntkvl eiplepknnm ratidcagil
      301 klrnadielr kgetdigrkn trvrlvfrvh vpepsgrivs lqaasnpiec sqrsahelpm
      361 verqdmdscl vyggqqmilt gqnftaeskv vfmekttdgq qiwemeatvd kdksqpnmlf
      421 veipeyrnkh irvpvkvnfy vingkrkrsq pqhftyhpvp aiktepsdey epslicspah
      481 gglgsqpyyp qhpmlaesps clvatmapcq qfrsglsspd aryqqqspaa alyqrsksls
      541 pgllgyqqps llaaplglad ahrsvlvhag sqgqgqgstl phtssasqqa spvihysptn
      601 qqlrggghqe fqhimycenf gpssarpgpp pinqgqrlsp gayptviqqq tapsqraakn
      661 gpsdqkealp tgvtvkqeqn ldqtylddvn eiirkefsgp psrnqt
//
LOCUS       NP_653131                644 aa            linear   ROD 09-OCT-2023
DEFINITION  interleukin-23 receptor precursor [Mus musculus].
ACCESSION   NP_653131
VERSION     NP_653131.3
DBSOURCE    REFSEQ: accession NM_144548.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 644)
  AUTHORS   Jacobse J, Brown RE, Li J, Pilat JM, Pham L, Short SP, Peek CT,
            Rolong A, Washington MK, Martinez-Barricarte R, Byndloss MX,
            Shelton C, Markle JG, Latour YL, Allaman MM, Cassat JE, Wilson KT,
            Choksi YA, Williams CS, Lau KS, Flynn CR, Casanova JL, Rings EHHM,
            Samsom JN and Goettel JA.
  TITLE     Interleukin-23 receptor signaling impairs the stability and
            function of colonic regulatory T cells
  JOURNAL   Cell Rep 42 (2), 112128 (2023)
   PUBMED   36807140
  REMARK    GeneRIF: Interleukin-23 receptor signaling impairs the stability
            and function of colonic regulatory T cells.
REFERENCE   2  (residues 1 to 644)
  AUTHORS   Hackstein CP, Costigan D, Drexhage L, Pearson C, Bullers S, Ilott
            N, Akther HD, Gu Y, FitzPatrick MEB, Harrison OJ, Garner LC, Mann
            EH, Pandey S, Friedrich M, Provine NM, Uhlig HH, Marchi E, Powrie
            F, Klenerman P and Thornton EE.
  TITLE     A conserved population of MHC II-restricted, innate-like,
            commensal-reactive T cells in the gut of humans and mice
  JOURNAL   Nat Commun 13 (1), 7472 (2022)
   PUBMED   36463279
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 644)
  AUTHORS   Li W, An N, Wang M, Liu X and Mei Z.
  TITLE     Interleukin-23 receptor defines T helper 1-like regulatory T cells
            in oral squamous cell carcinoma
  JOURNAL   Immun Inflamm Dis 10 (12), e746 (2022)
   PUBMED   36444617
  REMARK    GeneRIF: Interleukin-23 receptor defines T helper 1-like regulatory
            T cells in oral squamous cell carcinoma.
REFERENCE   4  (residues 1 to 644)
  AUTHORS   Viladomiu M, Khounlotham M, Dogan B, Lima SF, Elsaadi A, Cardakli
            E, Castellanos JG, Ng C, Herzog J, Schoenborn AA, Ellermann M, Liu
            B, Zhang S, Gulati AS, Sartor RB, Simpson KW, Lipkin SM and Longman
            RS.
  TITLE     Agr2-associated ER stress promotes adherent-invasive E. coli
            dysbiosis and triggers CD103+ dendritic cell IL-23-dependent
            ileocolitis
  JOURNAL   Cell Rep 41 (7), 111637 (2022)
   PUBMED   36384110
REFERENCE   5  (residues 1 to 644)
  AUTHORS   Pawlak M, DeTomaso D, Schnell A, Meyer Zu Horste G, Lee Y, Nyman J,
            Dionne D, Regan BML, Singh V, Delorey T, Schramm MA, Wang C,
            Wallrapp A, Burkett PR, Riesenfeld SJ, Anderson AC, Regev A, Xavier
            RJ, Yosef N and Kuchroo VK.
  TITLE     Induction of a colitogenic phenotype in Th1-like cells depends on
            interleukin-23 receptor signaling
  JOURNAL   Immunity 55 (9), 1663-1679 (2022)
   PUBMED   36070768
REFERENCE   6  (residues 1 to 644)
  AUTHORS   Chan JR, Blumenschein W, Murphy E, Diveu C, Wiekowski M, Abbondanzo
            S, Lucian L, Geissler R, Brodie S, Kimball AB, Gorman DM, Smith K,
            de Waal Malefyt R, Kastelein RA, McClanahan TK and Bowman EP.
  TITLE     IL-23 stimulates epidermal hyperplasia via TNF and
            IL-20R2-dependent mechanisms with implications for psoriasis
            pathogenesis
  JOURNAL   J Exp Med 203 (12), 2577-2587 (2006)
   PUBMED   17074928
REFERENCE   7  (residues 1 to 644)
  AUTHORS   Langowski JL, Zhang X, Wu L, Mattson JD, Chen T, Smith K, Basham B,
            McClanahan T, Kastelein RA and Oft M.
  TITLE     IL-23 promotes tumour incidence and growth
  JOURNAL   Nature 442 (7101), 461-465 (2006)
   PUBMED   16688182
REFERENCE   8  (residues 1 to 644)
  AUTHORS   Hoeve MA, Savage ND, de Boer T, Langenberg DM, de Waal Malefyt R,
            Ottenhoff TH and Verreck FA.
  TITLE     Divergent effects of IL-12 and IL-23 on the production of IL-17 by
            human T cells
  JOURNAL   Eur J Immunol 36 (3), 661-670 (2006)
   PUBMED   16482511
REFERENCE   9  (residues 1 to 644)
  AUTHORS   Parham C, Chirica M, Timans J, Vaisberg E, Travis M, Cheung J,
            Pflanz S, Zhang R, Singh KP, Vega F, To W, Wagner J, O'Farrell AM,
            McClanahan T, Zurawski S, Hannum C, Gorman D, Rennick DM, Kastelein
            RA, de Waal Malefyt R and Moore KW.
  TITLE     A receptor for the heterodimeric cytokine IL-23 is composed of
            IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R
  JOURNAL   J Immunol 168 (11), 5699-5708 (2002)
   PUBMED   12023369
REFERENCE   10 (residues 1 to 644)
  AUTHORS   Oppmann B, Lesley R, Blom B, Timans JC, Xu Y, Hunte B, Vega F, Yu
            N, Wang J, Singh K, Zonin F, Vaisberg E, Churakova T, Liu M, Gorman
            D, Wagner J, Zurawski S, Liu Y, Abrams JS, Moore KW, Rennick D, de
            Waal-Malefyt R, Hannum C, Bazan JF and Kastelein RA.
  TITLE     Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with
            biological activities similar as well as distinct from IL-12
  JOURNAL   Immunity 13 (5), 715-725 (2000)
   PUBMED   11114383
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124758.6 and AC159129.4.
            
            On Jul 29, 2021 this sequence version replaced NP_653131.2.
            
            CCDS Note: The coding region has been updated to extend the
            N-terminus. The use of an alternative upstream start codon would
            result in a protein that is 15 aa longer at the N-terminal.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF461423.1, BC112425.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..644
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 30.85 cM"
     Protein         1..644
                     /product="interleukin-23 receptor precursor"
                     /note="IL-23 receptor"
                     /calculated_mol_wt=70734
     sig_peptide     1..23
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=2737
     Site            47
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8K4B4.1)"
     Region          125..203
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; smart00060"
                     /db_xref="CDD:214495"
     Site            order(125,188,203)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Site            130
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8K4B4.1)"
     Site            232
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8K4B4.1)"
     Site            375..395
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K4B4.1)"
     CDS             1..644
                     /gene="Il23r"
                     /gene_synonym="IL-23R"
                     /coded_by="NM_144548.2:120..2054"
                     /db_xref="CCDS:CCDS39503.2"
                     /db_xref="GeneID:209590"
                     /db_xref="MGI:MGI:2181693"
ORIGIN      
        1 mshltlqlhv vialyvlfrw chggitsinc sgdmwvepge ifqmgmnvsi ycqealkhcr
       61 prnlyfykng fkeefditri nrttariwyk gfsephaymh ctaecpghfq etlicgkdis
      121 sghppdapsn ltcviyeysg nmtctwntgk ptyidtkyiv hvksleteee qqylassyvk
      181 istdslqgsr kylvwvqavn slgmensqql hvhlddivip sasiisraet tndtvpktiv
      241 ywksktmiek vfcemryktt tnqtwsvkef danftyvqqs efylepdsky vfqvrcqetg
      301 krnwqpwssp fvhqtsqetg krnwqpwssp fvhqtsqtvs qvtaksshep qkmemlsati
      361 frghpasgnh qdigllsgmv flaimlpifs ligifnrslr igikrkvllm ipkwlyedip
      421 nmensnvakl lqeksvfend naseqalyvd pvlteiseis plehkptdyk eerltgllet
      481 rdcplgmlst sssvvyipdl ntgykpqvsn vppggnlfin rderdptsle ttddhfarlk
      541 typnfqfsas smallnktli ldelclvlnq gefnsldikn srqeetsivl qsdspsetip
      601 aqtllsdefv sclaignedl psinsyfpqn vleshfsris lfqk
//
LOCUS       NP_001348624             503 aa            linear   ROD 09-OCT-2023
DEFINITION  nuclear respiratory factor 1 isoform a [Mus musculus].
ACCESSION   NP_001348624 XP_017176934
VERSION     NP_001348624.1
DBSOURCE    REFSEQ: accession NM_001361695.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 503)
  AUTHORS   Cheng C, Tian Y, Yang R, Guo W, Xiao K, Zhang F, Tian J, Deng Z,
            Yang W, Yang H and Zhou Z.
  TITLE     miR-5581 Contributes to Osteoarthritis by Targeting NRF1 to Disturb
            the Proliferation and Functions of Chondrocytes
  JOURNAL   Am J Pathol 193 (9), 1234-1247 (2023)
   PUBMED   37611970
  REMARK    GeneRIF: miR-5581 Contributes to Osteoarthritis by Targeting NRF1
            to Disturb the Proliferation and Functions of Chondrocytes.
REFERENCE   2  (residues 1 to 503)
  AUTHORS   Meng Z, Liang B, Wu Y, Liu C, Wang H, Du Y, Gan L, Gao E, Lau WB,
            Christopher TA, Lopez BL, Koch WJ, Ma X, Zhao F, Wang Y and Zhao J.
  TITLE     Hypoadiponectinemia-induced upregulation of microRNA449b
            downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury
            in diabetic mice
  JOURNAL   J Mol Cell Cardiol 182, 1-14 (2023)
   PUBMED   37437402
  REMARK    GeneRIF: Hypoadiponectinemia-induced upregulation of microRNA449b
            downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury
            in diabetic mice.
REFERENCE   3  (residues 1 to 503)
  AUTHORS   Zhao T, Zhang J, Lei H, Meng Y, Cheng H, Zhao Y, Geng G, Mu C, Chen
            L, Liu Q, Luo Q, Zhang C, Long Y, Su J, Wang Y, Li Z, Sun J, Chen
            G, Li Y, Liao X, Shang Y, Hu G, Chen Q and Zhu Y.
  TITLE     NRF1-mediated mitochondrial biogenesis antagonizes innate antiviral
            immunity
  JOURNAL   EMBO J 42 (16), e113258 (2023)
   PUBMED   37409632
  REMARK    GeneRIF: NRF1-mediated mitochondrial biogenesis antagonizes innate
            antiviral immunity.
REFERENCE   4  (residues 1 to 503)
  AUTHORS   Akl MG, Baccetto R, Stebbings BM, Li L and Widenmaier SB.
  TITLE     Euglycemia is affected by stress defense factor hepatocyte NRF1,
            but not NRF2
  JOURNAL   Biochem Biophys Res Commun 668, 96-103 (2023)
   PUBMED   37245295
  REMARK    GeneRIF: Euglycemia is affected by stress defense factor hepatocyte
            NRF1, but not NRF2.
REFERENCE   5  (residues 1 to 503)
  AUTHORS   Akl MG, Li L, Baccetto R, Phanse S, Zhang Q, Trites MJ, McDonald S,
            Aoki H, Babu M and Widenmaier SB.
  TITLE     Complementary gene regulation by NRF1 and NRF2 protects against
            hepatic cholesterol overload
  JOURNAL   Cell Rep 42 (4), 112399 (2023)
   PUBMED   37060561
  REMARK    GeneRIF: Complementary gene regulation by NRF1 and NRF2 protects
            against hepatic cholesterol overload.
            Erratum:[Cell Rep. 2023 Jul 25;42(7):112872. PMID: 37454293]
REFERENCE   6  (residues 1 to 503)
  AUTHORS   Carmona MC, Iglesias R, Obregon MJ, Darlington GJ, Villarroya F and
            Giralt M.
  TITLE     Mitochondrial biogenesis and thyroid status maturation in brown fat
            require CCAAT/enhancer-binding protein alpha
  JOURNAL   J Biol Chem 277 (24), 21489-21498 (2002)
   PUBMED   11940593
REFERENCE   7  (residues 1 to 503)
  AUTHORS   Huo L and Scarpulla RC.
  TITLE     Mitochondrial DNA instability and peri-implantation lethality
            associated with targeted disruption of nuclear respiratory factor 1
            in mice
  JOURNAL   Mol Cell Biol 21 (2), 644-654 (2001)
   PUBMED   11134350
REFERENCE   8  (residues 1 to 503)
  AUTHORS   Schaefer L, Engman H and Miller JB.
  TITLE     Coding sequence, chromosomal localization, and expression pattern
            of Nrf1: the mouse homolog of Drosophila erect wing
  JOURNAL   Mamm Genome 11 (2), 104-110 (2000)
   PUBMED   10656923
REFERENCE   9  (residues 1 to 503)
  AUTHORS   Huo L and Scarpulla RC.
  TITLE     Multiple 5'-untranslated exons in the nuclear respiratory factor 1
            gene span 47 kb and contribute to transcript heterogeneity and
            translational efficiency
  JOURNAL   Gene 233 (1-2), 213-224 (1999)
   PUBMED   10375638
REFERENCE   10 (residues 1 to 503)
  AUTHORS   Virbasius CA, Virbasius JV and Scarpulla RC.
  TITLE     NRF-1, an activator involved in nuclear-mitochondrial interactions,
            utilizes a new DNA-binding domain conserved in a family of
            developmental regulators
  JOURNAL   Genes Dev 7 (12A), 2431-2445 (1993)
   PUBMED   8253388
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153632.2.
            
            On Mar 29, 2018 this sequence version replaced XP_017176934.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.79505.1,
                                           SRR6116558.134883.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849390
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 12.47 cM"
     Protein         1..503
                     /product="nuclear respiratory factor 1 isoform a"
                     /note="NRF-1; alpha-pal; alpha palindromic-binding
                     protein"
                     /calculated_mol_wt=53440
     Region          1..78
                     /region_name="Dimerization. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU00.2)"
     Region          36..57
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU00.2)"
     Site            39
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:Q16656; propagated from
                     UniProtKB/Swiss-Prot (Q9WU00.2)"
     Site            44
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:Q16656; propagated from
                     UniProtKB/Swiss-Prot (Q9WU00.2)"
     Site            46
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:Q16656; propagated from
                     UniProtKB/Swiss-Prot (Q9WU00.2)"
     Site            47
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:Q16656; propagated from
                     UniProtKB/Swiss-Prot (Q9WU00.2)"
     Site            52
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:Q16656; propagated from
                     UniProtKB/Swiss-Prot (Q9WU00.2)"
     Region          87..283
                     /region_name="Nrf1_DNA-bind"
                     /note="NLS-binding and DNA-binding and dimerization
                     domains of Nrf1; pfam10491"
                     /db_xref="CDD:402218"
     Region          88..116
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU00.2)"
     Region          301..476
                     /region_name="Required for transcriptional activation.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU00.2)"
     Region          450..502
                     /region_name="Nrf1_activ_bdg"
                     /note="Nrf1 activator activation site binding domain;
                     pfam10492"
                     /db_xref="CDD:431313"
     CDS             1..503
                     /gene="Nrf1"
                     /gene_synonym="D6Ertd415e"
                     /coded_by="NM_001361695.2:1815..3326"
                     /note="isoform a is encoded by transcript variant 10"
                     /db_xref="CCDS:CCDS19968.1"
                     /db_xref="GeneID:18181"
                     /db_xref="MGI:MGI:1332235"
ORIGIN      
        1 meehgvtqte hmatieahav aqqvqqvhva tytehsmlsa dedspssped tsyddsdiln
       61 staadevtah laaagpvgma aaaavatgkk rkrphvfesn psirkrqqtr llrklratld
      121 eyttrvgqqa ivlcispskp npvfkvfgaa plenvvrkyk smiledlesa laehapapqe
      181 vnselpplti dgipvsvdkm tqaqlrafip emlkystgrg kpgwgkesck piwwpedipw
      241 anvrsdvrte eqkqrvswtq alrtivkncy kqhgredlly afedqqtqtq attthsiahl
      301 vpsqtvvqtf snpdgtvsli qvgtgatvat ladaselptt vtvaqvnysa vadgeveqnw
      361 atlqggemti qttqaseatq avaslaeaav aasqemqqga tvtmalnsea aahavatlae
      421 atlqgggqiv lsgetaaavg altgvqdang lvqipvsmyq tvvtslaqgn gpvqvamapv
      481 ttrisdsavt mdgqavevvt leq
//
LOCUS       NP_001157700             449 aa            linear   ROD 09-OCT-2023
DEFINITION  nuclear respiratory factor 1 isoform c [Mus musculus].
ACCESSION   NP_001157700
VERSION     NP_001157700.1
DBSOURCE    REFSEQ: accession NM_001164228.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 449)
  AUTHORS   Cheng C, Tian Y, Yang R, Guo W, Xiao K, Zhang F, Tian J, Deng Z,
            Yang W, Yang H and Zhou Z.
  TITLE     miR-5581 Contributes to Osteoarthritis by Targeting NRF1 to Disturb
            the Proliferation and Functions of Chondrocytes
  JOURNAL   Am J Pathol 193 (9), 1234-1247 (2023)
   PUBMED   37611970
  REMARK    GeneRIF: miR-5581 Contributes to Osteoarthritis by Targeting NRF1
            to Disturb the Proliferation and Functions of Chondrocytes.
REFERENCE   2  (residues 1 to 449)
  AUTHORS   Meng Z, Liang B, Wu Y, Liu C, Wang H, Du Y, Gan L, Gao E, Lau WB,
            Christopher TA, Lopez BL, Koch WJ, Ma X, Zhao F, Wang Y and Zhao J.
  TITLE     Hypoadiponectinemia-induced upregulation of microRNA449b
            downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury
            in diabetic mice
  JOURNAL   J Mol Cell Cardiol 182, 1-14 (2023)
   PUBMED   37437402
  REMARK    GeneRIF: Hypoadiponectinemia-induced upregulation of microRNA449b
            downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury
            in diabetic mice.
REFERENCE   3  (residues 1 to 449)
  AUTHORS   Zhao T, Zhang J, Lei H, Meng Y, Cheng H, Zhao Y, Geng G, Mu C, Chen
            L, Liu Q, Luo Q, Zhang C, Long Y, Su J, Wang Y, Li Z, Sun J, Chen
            G, Li Y, Liao X, Shang Y, Hu G, Chen Q and Zhu Y.
  TITLE     NRF1-mediated mitochondrial biogenesis antagonizes innate antiviral
            immunity
  JOURNAL   EMBO J 42 (16), e113258 (2023)
   PUBMED   37409632
  REMARK    GeneRIF: NRF1-mediated mitochondrial biogenesis antagonizes innate
            antiviral immunity.
REFERENCE   4  (residues 1 to 449)
  AUTHORS   Akl MG, Baccetto R, Stebbings BM, Li L and Widenmaier SB.
  TITLE     Euglycemia is affected by stress defense factor hepatocyte NRF1,
            but not NRF2
  JOURNAL   Biochem Biophys Res Commun 668, 96-103 (2023)
   PUBMED   37245295
  REMARK    GeneRIF: Euglycemia is affected by stress defense factor hepatocyte
            NRF1, but not NRF2.
REFERENCE   5  (residues 1 to 449)
  AUTHORS   Akl MG, Li L, Baccetto R, Phanse S, Zhang Q, Trites MJ, McDonald S,
            Aoki H, Babu M and Widenmaier SB.
  TITLE     Complementary gene regulation by NRF1 and NRF2 protects against
            hepatic cholesterol overload
  JOURNAL   Cell Rep 42 (4), 112399 (2023)
   PUBMED   37060561
  REMARK    GeneRIF: Complementary gene regulation by NRF1 and NRF2 protects
            against hepatic cholesterol overload.
            Erratum:[Cell Rep. 2023 Jul 25;42(7):112872. PMID: 37454293]
REFERENCE   6  (residues 1 to 449)
  AUTHORS   Carmona MC, Iglesias R, Obregon MJ, Darlington GJ, Villarroya F and
            Giralt M.
  TITLE     Mitochondrial biogenesis and thyroid status maturation in brown fat
            require CCAAT/enhancer-binding protein alpha
  JOURNAL   J Biol Chem 277 (24), 21489-21498 (2002)
   PUBMED   11940593
REFERENCE   7  (residues 1 to 449)
  AUTHORS   Huo L and Scarpulla RC.
  TITLE     Mitochondrial DNA instability and peri-implantation lethality
            associated with targeted disruption of nuclear respiratory factor 1
            in mice
  JOURNAL   Mol Cell Biol 21 (2), 644-654 (2001)
   PUBMED   11134350
REFERENCE   8  (residues 1 to 449)
  AUTHORS   Schaefer L, Engman H and Miller JB.
  TITLE     Coding sequence, chromosomal localization, and expression pattern
            of Nrf1: the mouse homolog of Drosophila erect wing
  JOURNAL   Mamm Genome 11 (2), 104-110 (2000)
   PUBMED   10656923
REFERENCE   9  (residues 1 to 449)
  AUTHORS   Huo L and Scarpulla RC.
  TITLE     Multiple 5'-untranslated exons in the nuclear respiratory factor 1
            gene span 47 kb and contribute to transcript heterogeneity and
            translational efficiency
  JOURNAL   Gene 233 (1-2), 213-224 (1999)
   PUBMED   10375638
REFERENCE   10 (residues 1 to 449)
  AUTHORS   Virbasius CA, Virbasius JV and Scarpulla RC.
  TITLE     NRF-1, an activator involved in nuclear-mitochondrial interactions,
            utilizes a new DNA-binding domain conserved in a family of
            developmental regulators
  JOURNAL   Genes Dev 7 (12A), 2431-2445 (1993)
   PUBMED   8253388
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134897.4 and AC153632.2.
            
            Transcript Variant: This variant (3) uses an alternate splice site
            in the 5' UTR, lacks a 3' coding exon, and contains an alternate
            exon in the 3' coding region which results in a frameshift and
            early stop codon, compared to variant 1. This results in a distinct
            and shorter C-terminus in isoform c, compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AK050861.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN01164137 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..449
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 12.47 cM"
     Protein         1..449
                     /product="nuclear respiratory factor 1 isoform c"
                     /note="NRF-1; alpha-pal; alpha palindromic-binding
                     protein"
                     /calculated_mol_wt=48996
     Region          1..78
                     /region_name="Dimerization. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU00.2)"
     Region          36..57
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU00.2)"
     Site            39
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:Q16656; propagated from
                     UniProtKB/Swiss-Prot (Q9WU00.2)"
     Site            44
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:Q16656; propagated from
                     UniProtKB/Swiss-Prot (Q9WU00.2)"
     Site            46
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:Q16656; propagated from
                     UniProtKB/Swiss-Prot (Q9WU00.2)"
     Site            47
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:Q16656; propagated from
                     UniProtKB/Swiss-Prot (Q9WU00.2)"
     Site            52
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:Q16656; propagated from
                     UniProtKB/Swiss-Prot (Q9WU00.2)"
     Region          87..283
                     /region_name="Nrf1_DNA-bind"
                     /note="NLS-binding and DNA-binding and dimerization
                     domains of Nrf1; pfam10491"
                     /db_xref="CDD:402218"
     Region          88..116
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU00.2)"
     CDS             1..449
                     /gene="Nrf1"
                     /gene_synonym="D6Ertd415e"
                     /coded_by="NM_001164228.2:271..1620"
                     /note="isoform c is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS51742.1"
                     /db_xref="GeneID:18181"
                     /db_xref="MGI:MGI:1332235"
ORIGIN      
        1 meehgvtqte hmatieahav aqqvqqvhva tytehsmlsa dedspssped tsyddsdiln
       61 staadevtah laaagpvgma aaaavatgkk rkrphvfesn psirkrqqtr llrklratld
      121 eyttrvgqqa ivlcispskp npvfkvfgaa plenvvrkyk smiledlesa laehapapqe
      181 vnselpplti dgipvsvdkm tqaqlrafip emlkystgrg kpgwgkesck piwwpedipw
      241 anvrsdvrte eqkqrvswtq alrtivkncy kqhgredlly afedqqtqtq attthsiahl
      301 vpsqtvvqtf snpdgtvsli qvgtgatvat ladaselptt vtvaqvnysa vadgeveqnw
      361 atlqggemti qttqaseatq avaslaeaav aasqemqqga tvtmalnrpr wsscmdhqqs
      421 rdgssgcrkd syrfwkgihy ggsnerrrs
//
LOCUS       NP_034563               1196 aa            linear   ROD 09-OCT-2023
DEFINITION  homeodomain-interacting protein kinase 2 isoform 2 [Mus musculus].
ACCESSION   NP_034563
VERSION     NP_034563.2
DBSOURCE    REFSEQ: accession NM_010433.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1196)
  AUTHORS   Wang G, Ma Z, Song C, Wang X and Zhou Z.
  TITLE     miR-147b is an oncomiR acting synergistically with HIPK2 to promote
            pancreatic carcinogenesis
  JOURNAL   Cell Signal 111, 110840 (2023)
   PUBMED   37543099
  REMARK    GeneRIF: miR-147b is an oncomiR acting synergistically with HIPK2
            to promote pancreatic carcinogenesis.
REFERENCE   2  (residues 1 to 1196)
  AUTHORS   Zhong W, Hong C, Dong Y, Li Y, Xiao C and Liu X.
  TITLE     ASH2L Aggravates Fibrosis and Inflammation through HIPK2 in High
            Glucose-Induced Glomerular Mesangial Cells
  JOURNAL   Genes (Basel) 13 (12), 2244 (2022)
   PUBMED   36553510
  REMARK    GeneRIF: ASH2L Aggravates Fibrosis and Inflammation through HIPK2
            in High Glucose-Induced Glomerular Mesangial Cells.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1196)
  AUTHORS   Zhou Q, Meng D, Li F, Zhang X, Liu L, Zhu Y, Liu S, Xu M, Deng J,
            Lei Z, Sluijter JPG and Xiao J.
  TITLE     Inhibition of HIPK2 protects stress-induced pathological cardiac
            remodeling
  JOURNAL   EBioMedicine 85, 104274 (2022)
   PUBMED   36182775
  REMARK    GeneRIF: Inhibition of HIPK2 protects stress-induced pathological
            cardiac remodeling.
REFERENCE   4  (residues 1 to 1196)
  AUTHORS   Cheung KL, Jaganathan A, Hu Y, Xu F, Lejeune A, Sharma R, Caescu
            CI, Meslamani J, Vincek A, Zhang F, Lee K, Zaware N, Qayum AA, Ren
            C, Kaplan MH, He JC, Xiong H and Zhou MM.
  TITLE     HIPK2 directs cell type-specific regulation of STAT3
            transcriptional activity in Th17 cell differentiation
  JOURNAL   Proc Natl Acad Sci U S A 119 (14), e2117112119 (2022)
   PUBMED   35344430
  REMARK    GeneRIF: HIPK2 directs cell type-specific regulation of STAT3
            transcriptional activity in Th17 cell differentiation.
REFERENCE   5  (residues 1 to 1196)
  AUTHORS   Yu Q, Liu L, Zhang X, Chang H, Ma S, Xie Z, Tang S, Ju X, Zhu H,
            Shen B and Zhang Q.
  TITLE     MiR-221-3p targets HIPK2 to promote diabetic wound healing
  JOURNAL   Microvasc Res 140, 104306 (2022)
   PUBMED   34973299
  REMARK    GeneRIF: MiR-221-3p targets HIPK2 to promote diabetic wound
            healing.
REFERENCE   6  (residues 1 to 1196)
  AUTHORS   Hofmann TG, Mincheva A, Lichter P, Droge W and Schmitz ML.
  TITLE     Human homeodomain-interacting protein kinase-2 (HIPK2) is a member
            of the DYRK family of protein kinases and maps to chromosome
            7q32-q34
  JOURNAL   Biochimie 82 (12), 1123-1127 (2000)
   PUBMED   11120354
REFERENCE   7  (residues 1 to 1196)
  AUTHORS   Wang W, Link V and Green JM.
  TITLE     Identification and cloning of a CD43-associated serine/threonine
            kinase
  JOURNAL   Cell Immunol 205 (1), 34-39 (2000)
   PUBMED   11078605
REFERENCE   8  (residues 1 to 1196)
  AUTHORS   Ebling FJ, Brooks AN, Cronin AS, Ford H and Kerr JB.
  TITLE     Estrogenic induction of spermatogenesis in the hypogonadal mouse
  JOURNAL   Endocrinology 141 (8), 2861-2869 (2000)
   PUBMED   10919273
REFERENCE   9  (residues 1 to 1196)
  AUTHORS   Kim YH, Choi CY and Kim Y.
  TITLE     Covalent modification of the homeodomain-interacting protein kinase
            2 (HIPK2) by the ubiquitin-like protein SUMO-1
  JOURNAL   Proc Natl Acad Sci U S A 96 (22), 12350-12355 (1999)
   PUBMED   10535925
REFERENCE   10 (residues 1 to 1196)
  AUTHORS   Kim YH, Choi CY, Lee SJ, Conti MA and Kim Y.
  TITLE     Homeodomain-interacting protein kinases, a novel family of
            co-repressors for homeodomain transcription factors
  JOURNAL   J Biol Chem 273 (40), 25875-25879 (1998)
   PUBMED   9748262
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154016.2, AF170302.1 and BM122543.2.
            
            On Apr 1, 2008 this sequence version replaced NP_034563.1.
            
            Transcript Variant: This variant (2) represents the longest
            transcript and encodes the longest isoform (2).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF170302.1, AF077659.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1196
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 17.85 cM"
     Protein         1..1196
                     /product="homeodomain-interacting protein kinase 2 isoform
                     2"
                     /EC_number="2.7.11.1"
                     /note="nuclear body-associated kinase 1; sialophorin
                     tail-associated nuclear serine/threonine-protein kinase"
                     /calculated_mol_wt=130368
     Site            16
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:23485397; propagated from
                     UniProtKB/Swiss-Prot (Q9QZR5.2)"
     Region          50..69
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZR5.2)"
     Region          97..230
                     /region_name="Transcriptional corepression"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZR5.2)"
     Site            118
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:23485397; propagated from
                     UniProtKB/Swiss-Prot (Q9QZR5.2)"
     Site            135
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:23485397; propagated from
                     UniProtKB/Swiss-Prot (Q9QZR5.2)"
     Site            141
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000269|PubMed:23485397; propagated from
                     UniProtKB/Swiss-Prot (Q9QZR5.2)"
     Region          183..537
                     /region_name="STKc_HIPK2"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     Homeodomain-Interacting Protein Kinase 2; cd14227"
                     /db_xref="CDD:271129"
     Region          189..520
                     /region_name="Interaction with DAXX.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZR5.2)"
     Site            order(205..209,213,226,228,242,261,277..280,283,285..286,
                     324,326,328..329,331,346,349,359,361..364,366,403)
                     /site_type="active"
                     /db_xref="CDD:271129"
     Site            order(205..209,213,226,228,261,277..280,283,324,326,
                     328..329,331,346)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271129"
     Site            order(242,285,324,326,349,359,361..364,366,403)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:271129"
     Site            252
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000269|PubMed:23485397; propagated from
                     UniProtKB/Swiss-Prot (Q9QZR5.2)"
     Site            273
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000269|PubMed:23485397; propagated from
                     UniProtKB/Swiss-Prot (Q9QZR5.2)"
     Site            345..366
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:271129"
     Site            361
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000269|PubMed:23485397; propagated from
                     UniProtKB/Swiss-Prot (Q9QZR5.2)"
     Site            441
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:23485397; propagated from
                     UniProtKB/Swiss-Prot (Q9QZR5.2)"
     Site            482
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000269|PubMed:23485397; propagated from
                     UniProtKB/Swiss-Prot (Q9QZR5.2)"
     Site            517
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000269|PubMed:23485397; propagated from
                     UniProtKB/Swiss-Prot (Q9QZR5.2)"
     Region          539..844
                     /region_name="Interaction with SKI and SMAD1.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZR5.2)"
     Site            566
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000269|PubMed:23485397; propagated from
                     UniProtKB/Swiss-Prot (Q9QZR5.2)"
     Region          600..800
                     /region_name="Interaction with DAZAP2.
                     /evidence=ECO:0000250|UniProtKB:Q9H2X6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZR5.2)"
     Site            634
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:23485397; propagated from
                     UniProtKB/Swiss-Prot (Q9QZR5.2)"
     Site            668
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:23485397; propagated from
                     UniProtKB/Swiss-Prot (Q9QZR5.2)"
     Site            687
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000269|PubMed:23485397; propagated from
                     UniProtKB/Swiss-Prot (Q9QZR5.2)"
     Region          752..897
                     /region_name="Interaction with POU4F1.
                     /evidence=ECO:0000269|PubMed:15492043"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZR5.2)"
     Region          774..876
                     /region_name="Interaction with CTBP1.
                     /evidence=ECO:0000269|PubMed:14567915"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZR5.2)"
     Region          787..897
                     /region_name="Interaction with HMGA1.
                     /evidence=ECO:0000269|PubMed:11593421"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZR5.2)"
     Region          792..847
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZR5.2)"
     Region          802..805
                     /region_name="Nuclear localization signal 1 (NLS1).
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZR5.2)"
     Site            815
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:23485397; propagated from
                     UniProtKB/Swiss-Prot (Q9QZR5.2)"
     Site            827
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:23485397,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9QZR5.2)"
     Region          832..835
                     /region_name="Nuclear localization signal 2 (NLS2).
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZR5.2)"
     Region          839..934
                     /region_name="Interaction with TP53 and TP73.
                     /evidence=ECO:0000269|PubMed:11780126"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZR5.2)"
     Region          873..980
                     /region_name="Localization to nuclear speckles"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZR5.2)"
     Region          873..980
                     /region_name="Required for localization to nuclear
                     speckles. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZR5.2)"
     Region          873..907
                     /region_name="Interaction with UBE2I.
                     /evidence=ECO:0000269|PubMed:10535925"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZR5.2)"
     Region          884..908
                     /region_name="SUMO interaction motifs (SIM), required for
                     nuclear localization and kinase activity.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZR5.2)"
     Region          891..963
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZR5.2)"
     Site            923..924
                     /site_type="cleavage"
                     /note="Cleavage, by CASP6. /evidence=ECO:0000250;
                     propagated from UniProtKB/Swiss-Prot (Q9QZR5.2)"
     Site            934
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:23485397; propagated from
                     UniProtKB/Swiss-Prot (Q9QZR5.2)"
     Region          935..1050
                     /region_name="Interaction with AXIN1.
                     /evidence=ECO:0000269|PubMed:15526030"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZR5.2)"
     Region          984..1196
                     /region_name="Autoinhibitory domain (AID).
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZR5.2)"
     Site            984..985
                     /site_type="cleavage"
                     /note="Cleavage, by CASP6. /evidence=ECO:0000250;
                     propagated from UniProtKB/Swiss-Prot (Q9QZR5.2)"
     Region          991..1058
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QZR5.2)"
     Site            991
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:23485397; propagated from
                     UniProtKB/Swiss-Prot (Q9QZR5.2)"
     Site            993
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:23485397; propagated from
                     UniProtKB/Swiss-Prot (Q9QZR5.2)"
     Site            1042
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:23485397; propagated from
                     UniProtKB/Swiss-Prot (Q9QZR5.2)"
     Site            1153
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:23485397; propagated from
                     UniProtKB/Swiss-Prot (Q9QZR5.2)"
     Site            1186
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:23485397; propagated from
                     UniProtKB/Swiss-Prot (Q9QZR5.2)"
     CDS             1..1196
                     /gene="Hipk2"
                     /gene_synonym="1110014O20Rik; B230339E18Rik; Stank"
                     /coded_by="NM_010433.2:374..3964"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS20017.2"
                     /db_xref="GeneID:15258"
                     /db_xref="MGI:MGI:1314872"
ORIGIN      
        1 mapvyegmas hvqvfsphtl qssafcsvkk lkvepssnwd mtgygshskv ysqsknipps
       61 qpasttvsts lpipnpslpy eqtiifpgst ghivvtsass tsvtgqvlgg phnlmrrstv
      121 slldtyqkcg lkrkseeien tssvqiieeh ppmiqnnasg atvatattst atsknsgsns
      181 egdyqlvqhe vlcsmtntye vleflgrgtf gqvvkcwkrg tneivaikil knhpsyarqg
      241 qievsilarl stesaddynf vrayecfqhk nhtclvfeml eqnlydflkq nkfsplplky
      301 irpvlqqvat almklkslgl ihadlkpeni mlvdpsrqpy rvkvidfgsa shvskavcst
      361 ylqsryyrap eiilglpfce aidmwslgcv iaelflgwpl ypgaseydqi ryisqtqglp
      421 aeyllsagtk ttrffnrdtd spyplwrlkt pddheaetgi kskearkyif nclddmaqvn
      481 mttdlegsdm lvekadrref idllkkmlti dadkrvtpie tlnhpfvtmt hlldfphsah
      541 vkscfqnmei ckrrvnmydt vnqsktpfit hvapststnl tmtfnnqltt vhnqapttss
      601 atlslanpev silnyqsaly qpsaasmaav aprsmplqtg taqicarpdp fqqalivcpp
      661 gfqglqasps khagysvrme navpivtqap gaqplqiqpg llaqqawpgg aqqillppaw
      721 qqltgvatht svqhaavipe tmagtqqlad wrnthahgsh ynpimqqpal ltghvtlpaa
      781 qplnvgvahv mrqqptstts srkskqhqss vrnvstcevt ssqaisspqr skrvkentpp
      841 rcamvhsspa cstsvtcgwg dvassttrer qrqtivipdt psptvsviti ssdtdeeeeq
      901 khaptstvsk qrknviscvt vhdspysdss sntspysvqq rtghngtntl dtkgglenhc
      961 tgnprtiivp plktqasevl vecdslgpai sashhsssfk skssstvtst sghssgsssg
     1021 aiayrqqrpg phfqqqqpln lsqaqqhmaa drtgshrrqq ayitptmaqa pytfphnsps
     1081 hgtvhphlaa aahlptqphl ytytaptalg stgtvahlva sqgsarhtvq htaypasivh
     1141 qvpvsmgprv lpsptihpsq ypaqfahqty isaspastvy tgyplspakv nqypyi
//
LOCUS       NP_001392987             110 aa            linear   ROD 09-OCT-2023
DEFINITION  bcl-2-like protein 11 isoform 3 [Mus musculus].
ACCESSION   NP_001392987
VERSION     NP_001392987.1
DBSOURCE    REFSEQ: accession NM_001406058.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 110)
  AUTHORS   Jiang M, Wang XB and Jiang S.
  TITLE     circ_0000018 downregulation peripherally ameliorates
            neuroprotection against acute ischemic stroke through the
            miR-871/BCL2L11 axis
  JOURNAL   Mol Med Rep 28 (5) (2023)
   PUBMED   37772397
  REMARK    GeneRIF: circ_0000018 downregulation peripherally ameliorates
            neuroprotection against acute ischemic stroke through the
            miR-871/BCL2L11 axis.
REFERENCE   2  (residues 1 to 110)
  AUTHORS   Lu Y, Tang K, Wang S, Tian Z, Fan Y, Li B, Wang M, Zhao J and Xie
            J.
  TITLE     Dach1 deficiency drives alveolar epithelium apoptosis in pulmonary
            fibrosis via modulating C-Jun/Bim activity
  JOURNAL   Transl Res 257, 54-65 (2023)
   PUBMED   36754276
  REMARK    GeneRIF: Dach1 deficiency drives alveolar epithelium apoptosis in
            pulmonary fibrosis via modulating C-Jun/Bim activity.
REFERENCE   3  (residues 1 to 110)
  AUTHORS   Nguyen HV, Vandenberg CJ, Robati MR, Ng AP and Cory S.
  TITLE     MNT suppresses T cell apoptosis via BIM and is critical for T
            lymphomagenesis
  JOURNAL   Cell Death Differ 30 (4), 1018-1032 (2023)
   PUBMED   36755068
  REMARK    GeneRIF: MNT suppresses T cell apoptosis via BIM and is critical
            for T lymphomagenesis.
REFERENCE   4  (residues 1 to 110)
  AUTHORS   Chen H, Bai Y, Kobayashi M, Xiao S, Cai W, Barajas S, Chen S, Miao
            J, Meke FN, Vemula S, Ropa JP, Croop JM, Boswell HS, Wan J, Jia Y,
            Liu H, Li LS, Altman JK, Eklund EA, Ji P, Tong W, Band H, Huang DT,
            Platanias LC, Zhang ZY and Liu Y.
  TITLE     PRL2 phosphatase enhances oncogenic FLT3 signaling via
            dephosphorylation of the E3 ubiquitin ligase CBL at tyrosine 371
  JOURNAL   Blood 141 (3), 244-259 (2023)
   PUBMED   36206490
REFERENCE   5  (residues 1 to 110)
  AUTHORS   Brahma MK, Xiao P, Popa M, Negueruela J, Vandenbempt V, Demine S,
            Cardozo AK and Gurzov EN.
  TITLE     Nova1 or Bim Deficiency in Pancreatic beta-Cells Does Not Alter
            Multiple Low-Dose Streptozotocin-Induced Diabetes and Diet-Induced
            Obesity in Mice
  JOURNAL   Nutrients 14 (18), 3866 (2022)
   PUBMED   36145242
  REMARK    GeneRIF: Nova1 or Bim Deficiency in Pancreatic beta-Cells Does Not
            Alter Multiple Low-Dose Streptozotocin-Induced Diabetes and
            Diet-Induced Obesity in Mice.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 110)
  AUTHORS   Bouillet P, Zhang LC, Huang DC, Webb GC, Bottema CD, Shore P, Eyre
            HJ, Sutherland GR and Adams JM.
  TITLE     Gene structure alternative splicing, and chromosomal localization
            of pro-apoptotic Bcl-2 relative Bim
  JOURNAL   Mamm Genome 12 (2), 163-168 (2001)
   PUBMED   11210187
REFERENCE   7  (residues 1 to 110)
  AUTHORS   Bouillet P, Metcalf D, Huang DC, Tarlinton DM, Kay TW, Kontgen F,
            Adams JM and Strasser A.
  TITLE     Proapoptotic Bcl-2 relative Bim required for certain apoptotic
            responses, leukocyte homeostasis, and to preclude autoimmunity
  JOURNAL   Science 286 (5445), 1735-1738 (1999)
   PUBMED   10576740
REFERENCE   8  (residues 1 to 110)
  AUTHORS   Puthalakath H, Huang DC, O'Reilly LA, King SM and Strasser A.
  TITLE     The proapoptotic activity of the Bcl-2 family member Bim is
            regulated by interaction with the dynein motor complex
  JOURNAL   Mol Cell 3 (3), 287-296 (1999)
   PUBMED   10198631
REFERENCE   9  (residues 1 to 110)
  AUTHORS   Reed JC.
  TITLE     Bcl-2 family proteins
  JOURNAL   Oncogene 17 (25), 3225-3236 (1998)
   PUBMED   9916985
  REMARK    Review article
REFERENCE   10 (residues 1 to 110)
  AUTHORS   O'Connor L, Strasser A, O'Reilly LA, Hausmann G, Adams JM, Cory S
            and Huang DC.
  TITLE     Bim: a novel member of the Bcl-2 family that promotes apoptosis
  JOURNAL   EMBO J 17 (2), 384-395 (1998)
   PUBMED   9430630
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL805950.11.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10662773.1089702.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..110
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 62.23 cM"
     Protein         1..110
                     /product="bcl-2-like protein 11 isoform 3"
                     /note="bcl-2-like protein 11; bcl2-interacting mediator of
                     cell death; Bcl2 interacting mediator of cell death;
                     BCL2-like 11 (apoptosis facilitator)"
                     /calculated_mol_wt=12823
     Region          4..40
                     /region_name="Bim_N"
                     /note="Bim protein N-terminus; pfam06773"
                     /db_xref="CDD:429111"
     Region          43..78
                     /region_name="Bclx_interact"
                     /note="Bcl-x interacting, BH3 domain; pfam08945"
                     /db_xref="CDD:430337"
     CDS             1..110
                     /gene="Bcl2l11"
                     /gene_synonym="1500006F24Rik; bcl2-L-11; Bim; Bod"
                     /coded_by="NM_001406058.1:221..553"
                     /note="isoform 3 is encoded by transcript variant 7"
                     /db_xref="GeneID:12125"
                     /db_xref="MGI:MGI:1197519"
ORIGIN      
        1 makqpsdvss ecdreggqlq paerppqlrp gaptslqtep qasirqsqee pedlrpeiri
       61 aqelrrigde fnetytrrvf andyreaedh pqmvilqllr fifrlvwrrh
//
LOCUS       NP_001397371             894 aa            linear   ROD 09-OCT-2023
DEFINITION  nuclear factor NF-kappa-B p105 subunit isoform 2 [Mus musculus].
ACCESSION   NP_001397371 XP_006501169
VERSION     NP_001397371.1
DBSOURCE    REFSEQ: accession NM_001410442.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 894)
  AUTHORS   Lin LL, Song GJ, Zhang H, Yin Y, Xin SM, Ding L and Li Y.
  TITLE     GPR34 Knockdown Relieves Cognitive Deficits and Suppresses
            Neuroinflammation in Alzheimer's Disease via the ERK/NF-kappaB
            Signal
  JOURNAL   Neuroscience 528, 129-139 (2023)
   PUBMED   37557947
  REMARK    GeneRIF: GPR34 Knockdown Relieves Cognitive Deficits and Suppresses
            Neuroinflammation in Alzheimer's Disease via the ERK/NF-kappaB
            Signal.
REFERENCE   2  (residues 1 to 894)
  AUTHORS   Harding O, Holzer E, Riley JF, Martens S and Holzbaur ELF.
  TITLE     Damaged mitochondria recruit the effector NEMO to activate
            NF-kappaB signaling
  JOURNAL   Mol Cell 83 (17), 3188-3204 (2023)
   PUBMED   37683611
  REMARK    GeneRIF: Damaged mitochondria recruit the effector NEMO to activate
            NF-kappaB signaling.
REFERENCE   3  (residues 1 to 894)
  AUTHORS   Zhuang L, Zong X, Yang Q, Fan Q and Tao R.
  TITLE     Interleukin-34-NF-kappaB signaling aggravates myocardial
            ischemic/reperfusion injury by facilitating macrophage recruitment
            and polarization
  JOURNAL   EBioMedicine 95, 104744 (2023)
   PUBMED   37556943
  REMARK    GeneRIF: Interleukin-34-NF-kappaB signaling aggravates myocardial
            ischemic/reperfusion injury by facilitating macrophage recruitment
            and polarization.
REFERENCE   4  (residues 1 to 894)
  AUTHORS   Mao W, Wang X, Zhang Y, Zhu H, Dai L and Chen J.
  TITLE     Nuclear factor-kappa B p50-induced microRNA-20a-3p plays a
            detrimental role in sepsis-induced acute kidney injury
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (8), 198-202 (2023)
   PUBMED   37715384
  REMARK    GeneRIF: Nuclear factor-kappa B p50-induced microRNA-20a-3p plays a
            detrimental role in sepsis-induced acute kidney injury.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 894)
  AUTHORS   Verma M, Verma D, Sripada AS, Sirohi K, Varma R, Sahu A and Alam R.
  TITLE     NFkappaB1 inhibits memory formation and supports effector function
            of ILC2s in memory-driven asthma
  JOURNAL   Front Immunol 14, 1217776 (2023)
   PUBMED   37575259
  REMARK    GeneRIF: NFkappaB1 inhibits memory formation and supports effector
            function of ILC2s in memory-driven asthma.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 894)
  AUTHORS   Wulczyn FG, Naumann M and Scheidereit C.
  TITLE     Candidate proto-oncogene bcl-3 encodes a subunit-specific inhibitor
            of transcription factor NF-kappa B
  JOURNAL   Nature 358 (6387), 597-599 (1992)
   PUBMED   1501714
REFERENCE   7  (residues 1 to 894)
  AUTHORS   Inoue J, Kerr LD, Kakizuka A and Verma IM.
  TITLE     I kappa B gamma, a 70 kd protein identical to the C-terminal half
            of p110 NF-kappa B: a new member of the I kappa B family
  JOURNAL   Cell 68 (6), 1109-1120 (1992)
   PUBMED   1339305
REFERENCE   8  (residues 1 to 894)
  AUTHORS   Ryseck RP, Bull P, Takamiya M, Bours V, Siebenlist U, Dobrzanski P
            and Bravo R.
  TITLE     RelB, a new Rel family transcription activator that can interact
            with p50-NF-kappa B
  JOURNAL   Mol Cell Biol 12 (2), 674-684 (1992)
   PUBMED   1732739
REFERENCE   9  (residues 1 to 894)
  AUTHORS   Nolan GP, Ghosh S, Liou HC, Tempst P and Baltimore D.
  TITLE     DNA binding and I kappa B inhibition of the cloned p65 subunit of
            NF-kappa B, a rel-related polypeptide
  JOURNAL   Cell 64 (5), 961-969 (1991)
   PUBMED   2001591
REFERENCE   10 (residues 1 to 894)
  AUTHORS   Ghosh S, Gifford AM, Riviere LR, Tempst P, Nolan GP and Baltimore
            D.
  TITLE     Cloning of the p50 DNA binding subunit of NF-kappa B: homology to
            rel and dorsal
  JOURNAL   Cell 62 (5), 1019-1029 (1990)
   PUBMED   2203532
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC101973.7 and AC110164.26.
            
            On Aug 8, 2022 this sequence version replaced XP_006501169.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422586.557221.1,
                                           SRR13422600.150448.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..894
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 62.82 cM"
     Protein         1..894
                     /product="nuclear factor NF-kappa-B p105 subunit isoform
                     2"
                     /note="nuclear factor NF-kappa-B p105 subunit; EBP-1;
                     DNA-binding factor KBF1; NF-kappa-B1 p84/NF-kappa-B1 p98;
                     nuclear factor of kappa light chain gene enhancer in
                     B-cells 1, p105; NF kappaB1; NF-kappaB p50; p50 subunit of
                     NF kappaB; nuclear factor kappaB p50"
                     /calculated_mol_wt=97283
     Region          40..241
                     /region_name="RHD-n_NFkB1"
                     /note="N-terminal sub-domain of the Rel homology domain
                     (RHD) of nuclear factor of kappa B1 (NF-kappa B1);
                     cd07935"
                     /db_xref="CDD:143651"
     Site            order(54,56..57,59..60,63..66,141,143..144,241)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143651"
     Region          248..349
                     /region_name="IPT_NFkappaB"
                     /note="IPT domain of the transcription factor NFkappaB and
                     related transcription factors. NFkappaB is considered a
                     central regulator of stress responses, activated by
                     different stressful conditions, including physical stress,
                     oxidative stress, and exposure to...; cd01177"
                     /db_xref="CDD:238582"
     Site            order(249,251..253,255..257,297..299,312,324,343,346,348)
                     /site_type="other"
                     /note="ankyrin protein binding site [polypeptide binding]"
                     /db_xref="CDD:238582"
     Site            order(251..252,254,267,269,271,304..305,308,310)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:238582"
     Site            order(272,274,305..306)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238582"
     Site            335
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKA. /evidence=ECO:0000255;
                     propagated from UniProtKB/Swiss-Prot (P25799.2)"
     Region          358..363
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (P25799.2)"
     Region          370..392
                     /region_name="GRR. /evidence=ECO:0000250|UniProtKB:P19838"
                     /note="propagated from UniProtKB/Swiss-Prot (P25799.2)"
     Site            431..432
                     /site_type="cleavage"
                     /note="Cleavage (when cotranslationally processed).
                     /evidence=ECO:0000250|UniProtKB:P19838; propagated from
                     UniProtKB/Swiss-Prot (P25799.2)"
     Site            438
                     /site_type="acetylation"
                     /note="N6-acetyllysine, by EP300.
                     /evidence=ECO:0000250|UniProtKB:P19838; propagated from
                     UniProtKB/Swiss-Prot (P25799.2)"
     Region          439..470
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P25799.2)"
     Site            447
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P25799.2)"
     Region          <534..608
                     /region_name="Ank_2"
                     /note="Ankyrin repeats (3 copies); pfam12796"
                     /db_xref="CDD:432791"
     Site            order(538,540,544..545,548..550,552..553,557,560,575,577,
                     579,583..584,587..589,591..592,596,599,608,610,612,
                     616..617,620..622,624..625,629,632)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          538..575
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          577..608
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          582..676
                     /region_name="Ank_2"
                     /note="Ankyrin repeats (3 copies); pfam12796"
                     /db_xref="CDD:432791"
     Site            order(646,648,652..653,656..658,660..661,665,668,677,680,
                     682,686..687,690..692,694..695,700,703,712,714,716,
                     720..721,724..726,728)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          646..680
                     /region_name="Essential for interaction with HIF1AN.
                     /evidence=ECO:0000250|UniProtKB:P19838"
                     /note="propagated from UniProtKB/Swiss-Prot (P25799.2)"
     Region          646..677
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          651..>727
                     /region_name="Ank_2"
                     /note="Ankyrin repeats (3 copies); pfam12796"
                     /db_xref="CDD:432791"
     Site            674
                     /site_type="hydroxylation"
                     /note="(3S)-3-hydroxyasparagine, by HIF1AN.
                     /evidence=ECO:0000250|UniProtKB:P19838; propagated from
                     UniProtKB/Swiss-Prot (P25799.2)"
     Region          680..712
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            755
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q63369; propagated from
                     UniProtKB/Swiss-Prot (P25799.2)"
     Region          812..>865
                     /region_name="DD"
                     /note="Death Domain Superfamily of protein-protein
                     interaction domains; cl14633"
                     /db_xref="CDD:449339"
     CDS             1..894
                     /gene="Nfkb1"
                     /gene_synonym="NF-kappaB; NF-kappaB1; NF-KB1; p105; p50;
                     p50/p105"
                     /coded_by="NM_001410442.1:421..3105"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="GeneID:18033"
                     /db_xref="MGI:MGI:97312"
ORIGIN      
        1 madddpygtg qmfhlntalt hsifnaelys peiplstdgp ylqileqpkq rgfrfryvce
       61 gpshgglpga sseknkksyp qvkicnyvgp akvivqlvtn gknihlhahs lvgkhcedgv
      121 ctvtagpkdm vvgfanlgil hvtkkkvfet learmteaci rgynpgllvh sdlaylqaeg
      181 ggdrqltdre keiirqaavq qtkemdlsvv rlmftaflpd stgsftrrle pvvsdaiyds
      241 kapnasnlki vrmdrtagcv tggeeiyllc dkvqkddiqi rfyeeeengg vwegfgdfsp
      301 tdvhrqfaiv fktpkykdvn itkpasvfvq lrrksdlets epkpflyype ikdkeevqrk
      361 rqklmpnfsd sfgggsgaga ggggmfgsgg gggstgspgp gygysnygfp pyggitfhpg
      421 vtksnagvth gtintkfkng pkdcaksdde esltlpeket egegpslpma ctktepiala
      481 stmedkeqdm gfqdnlflek alqlarrhan alfdyavtgd vkmllavqrh ltavqdengd
      541 svlhlaiihl haqlvrdlle vtsglisddi inmrndlyqt plhlavitkq edvvedllrv
      601 gadlslldrw gnsvlhlaak eghdrilsil lksrkaapli dhpngeglna ihiavmsnsl
      661 pcllllvaag aevnaqeqks grtalhlave ydnislagcl llegdahvds ttydgttplh
      721 iaagrgstrl aallkaagad plvenfeply dlddswekag edegvvpgtt pldmaanwqv
      781 fdilngkpye pvftsddilp qgdmkqlted trlqlcklle ipdpdknwat laqklglgil
      841 nnafrlspap sktlmdnyem nsgivtasvt vvwrhpsans alqsllleta hcyl
//
LOCUS       NP_001349224             505 aa            linear   ROD 09-OCT-2023
DEFINITION  CUGBP Elav-like family member 4 isoform 20 [Mus musculus].
ACCESSION   NP_001349224 XP_017173281
VERSION     NP_001349224.1
DBSOURCE    REFSEQ: accession NM_001362295.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 505)
  AUTHORS   Salamon I, Park Y, Miskic T, Kopic J, Matteson P, Page NF, Roque A,
            McAuliffe GW, Favate J, Garcia-Forn M, Shah P, Judas M, Millonig
            JH, Kostovic I, De Rubeis S, Hart RP, Krsnik Z and Rasin MR.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    GeneRIF: Celf4 controls mRNA translation underlying synaptic
            development in the prenatal mammalian neocortex.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 505)
  AUTHORS   Shen Y, Zhang C, Xiao K, Liu D and Xie G.
  TITLE     CELF4 regulates spine formation and depression-like behaviors of
            mice
  JOURNAL   Biochem Biophys Res Commun 605, 39-44 (2022)
   PUBMED   35306363
  REMARK    GeneRIF: CELF4 regulates spine formation and depression-like
            behaviors of mice.
REFERENCE   3  (residues 1 to 505)
  AUTHORS   Moreau MX, Saillour Y, Cwetsch AW, Pierani A and Causeret F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   4  (residues 1 to 505)
  AUTHORS   Li C, Li X, Bi Z, Sugino K, Wang G, Zhu T and Liu Z.
  TITLE     Comprehensive transcriptome analysis of cochlear spiral ganglion
            neurons at multiple ages
  JOURNAL   Elife 9, e50491 (2020)
   PUBMED   31913118
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 505)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 505)
  AUTHORS   Ladd AN, Taffet G, Hartley C, Kearney DL and Cooper TA.
  TITLE     Cardiac tissue-specific repression of CELF activity disrupts
            alternative splicing and causes cardiomyopathy
  JOURNAL   Mol Cell Biol 25 (14), 6267-6278 (2005)
   PUBMED   15988035
  REMARK    GeneRIF: CELF protein activity is required for normal alternative
            splicing in the heart in vivo and normal CELF-mediated alternative
            splicing regulation is in turn required for normal cardiac
            function.
REFERENCE   7  (residues 1 to 505)
  AUTHORS   Meins M, Schlickum S, Wilhelm C, Missbach J, Yadav S, Glaser B,
            Grzmil M, Burfeind P and Laccone F.
  TITLE     Identification and characterization of murine Brunol4, a new member
            of the elav/bruno family
  JOURNAL   Cytogenet Genome Res 97 (3-4), 254-260 (2002)
   PUBMED   12438720
  REMARK    GeneRIF: cloning and characterization
REFERENCE   8  (residues 1 to 505)
  AUTHORS   Ladd AN, Charlet N and Cooper TA.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   9  (residues 1 to 505)
  AUTHORS   Good PJ, Chen Q, Warner SJ and Herring DC.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
REFERENCE   10 (residues 1 to 505)
  AUTHORS   Yulug IG, Egan SE, See CG and Fisher EM.
  TITLE     Mapping GRB2, a signal transduction gene in the human and the mouse
  JOURNAL   Genomics 22 (2), 313-318 (1994)
   PUBMED   7806216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121094.8 and AC144938.3.
            
            On Apr 12, 2018 this sequence version replaced XP_017173281.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.3929425.1,
                                           SRR1660815.227794.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 13.92 cM"
     Protein         1..505
                     /product="CUGBP Elav-like family member 4 isoform 20"
                     /note="CUG-BP- and ETR-3-like factor 4; bruno-like protein
                     4; RNA-binding protein BRUNOL-4; bruno-like 4, RNA binding
                     protein"
                     /calculated_mol_wt=53878
     Region          49..135
                     /region_name="RRM1_CELF3_4_5_6"
                     /note="RNA recognition motif 1 (RRM1) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12632"
                     /db_xref="CDD:410041"
     Site            order(55,57,59..60,63,82,84,86,95..97,99,129,131)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410041"
     Region          150..230
                     /region_name="RRM2_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12635"
                     /db_xref="CDD:410043"
     Site            order(152,154,156..157,160,179,181,183,191..193,195,225,
                     227)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410043"
     Region          416..494
                     /region_name="RRM3_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12639"
                     /db_xref="CDD:241083"
     CDS             1..505
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /coded_by="NM_001362295.1:531..2048"
                     /note="isoform 20 is encoded by transcript variant 26"
                     /db_xref="GeneID:108013"
                     /db_xref="MGI:MGI:1932407"
ORIGIN      
        1 myikmatlan gqadnaslst nglgsspgsa ghmnglshsp gnpstipmkd hdaiklfigq
       61 iprnldekdl kplfeefgki yeltvlkdrf tgmhkgcafl tyceresalk aqsalheqkt
      121 lpgmnrpiqv kpadsesrgg ssclrqppsh rklfvgmlnk qqseddvrrl feafgnieec
      181 tilrgpdgns kgcafvkyss haeaqaaina lhgsqtmpga ssslvvkfad tdkertmrrm
      241 qqmagqmgmf npmaipfgay gayaqalmqq qaalmasvaq ggylnpmaaf aaaqmqqmaa
      301 lnmnglaaap mtptsggstp pgitapavps ipspigvngf tglppqangq paaeavfang
      361 ihpypaqspt aadplqqaya gvqqyagpaa ypaaygqisq afpqpppmip qqqregpegc
      421 nlliyhlpqe fgdaelmqmf lpfgnvissk vfvdratnqs kcfgfvsfdn pasaqtaiqa
      481 mngfqigmkr lkvqlkrpkd anrpy
//
LOCUS       NP_001349239             492 aa            linear   ROD 09-OCT-2023
DEFINITION  CUGBP Elav-like family member 4 isoform 32 [Mus musculus].
ACCESSION   NP_001349239
VERSION     NP_001349239.1
DBSOURCE    REFSEQ: accession NM_001362310.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 492)
  AUTHORS   Salamon I, Park Y, Miskic T, Kopic J, Matteson P, Page NF, Roque A,
            McAuliffe GW, Favate J, Garcia-Forn M, Shah P, Judas M, Millonig
            JH, Kostovic I, De Rubeis S, Hart RP, Krsnik Z and Rasin MR.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    GeneRIF: Celf4 controls mRNA translation underlying synaptic
            development in the prenatal mammalian neocortex.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 492)
  AUTHORS   Shen Y, Zhang C, Xiao K, Liu D and Xie G.
  TITLE     CELF4 regulates spine formation and depression-like behaviors of
            mice
  JOURNAL   Biochem Biophys Res Commun 605, 39-44 (2022)
   PUBMED   35306363
  REMARK    GeneRIF: CELF4 regulates spine formation and depression-like
            behaviors of mice.
REFERENCE   3  (residues 1 to 492)
  AUTHORS   Moreau MX, Saillour Y, Cwetsch AW, Pierani A and Causeret F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   4  (residues 1 to 492)
  AUTHORS   Li C, Li X, Bi Z, Sugino K, Wang G, Zhu T and Liu Z.
  TITLE     Comprehensive transcriptome analysis of cochlear spiral ganglion
            neurons at multiple ages
  JOURNAL   Elife 9, e50491 (2020)
   PUBMED   31913118
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 492)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 492)
  AUTHORS   Ladd AN, Taffet G, Hartley C, Kearney DL and Cooper TA.
  TITLE     Cardiac tissue-specific repression of CELF activity disrupts
            alternative splicing and causes cardiomyopathy
  JOURNAL   Mol Cell Biol 25 (14), 6267-6278 (2005)
   PUBMED   15988035
  REMARK    GeneRIF: CELF protein activity is required for normal alternative
            splicing in the heart in vivo and normal CELF-mediated alternative
            splicing regulation is in turn required for normal cardiac
            function.
REFERENCE   7  (residues 1 to 492)
  AUTHORS   Meins M, Schlickum S, Wilhelm C, Missbach J, Yadav S, Glaser B,
            Grzmil M, Burfeind P and Laccone F.
  TITLE     Identification and characterization of murine Brunol4, a new member
            of the elav/bruno family
  JOURNAL   Cytogenet Genome Res 97 (3-4), 254-260 (2002)
   PUBMED   12438720
  REMARK    GeneRIF: cloning and characterization
REFERENCE   8  (residues 1 to 492)
  AUTHORS   Ladd AN, Charlet N and Cooper TA.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   9  (residues 1 to 492)
  AUTHORS   Good PJ, Chen Q, Warner SJ and Herring DC.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
REFERENCE   10 (residues 1 to 492)
  AUTHORS   Yulug IG, Egan SE, See CG and Fisher EM.
  TITLE     Mapping GRB2, a signal transduction gene in the human and the mouse
  JOURNAL   Genomics 22 (2), 313-318 (1994)
   PUBMED   7806216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121094.8 and AC144938.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660821.113226.1,
                                           SRR1660813.152403.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..492
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 13.92 cM"
     Protein         1..492
                     /product="CUGBP Elav-like family member 4 isoform 32"
                     /note="CUG-BP- and ETR-3-like factor 4; bruno-like protein
                     4; RNA-binding protein BRUNOL-4; bruno-like 4, RNA binding
                     protein"
                     /calculated_mol_wt=52317
     Region          49..135
                     /region_name="RRM1_CELF3_4_5_6"
                     /note="RNA recognition motif 1 (RRM1) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12632"
                     /db_xref="CDD:410041"
     Site            order(55,57,59..60,63,82,84,86,95..97,99,129,131)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410041"
     Region          140..220
                     /region_name="RRM2_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12635"
                     /db_xref="CDD:410043"
     Site            order(142,144,146..147,150,169,171,173,181..183,185,215,
                     217)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410043"
     Region          405..481
                     /region_name="RRM_SF"
                     /note="RNA recognition motif (RRM) superfamily; cl17169"
                     /db_xref="CDD:450164"
     CDS             1..492
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /coded_by="NM_001362310.1:531..2009"
                     /note="isoform 32 is encoded by transcript variant 36"
                     /db_xref="GeneID:108013"
                     /db_xref="MGI:MGI:1932407"
ORIGIN      
        1 myikmatlan gqadnaslst nglgsspgsa ghmnglshsp gnpstipmkd hdaiklfigq
       61 iprnldekdl kplfeefgki yeltvlkdrf tgmhkgcafl tyceresalk aqsalheqkt
      121 lpgmnrpiqv kpadsesrgd rklfvgmlnk qqseddvrrl feafgnieec tilrgpdgns
      181 kgcafvkyss haeaqaaina lhgsqtmpga ssslvvkfad tdkertmrrm qqmagqmgmf
      241 npmaipfgay gayaqalmqq qaalmasvaq ggylnpmaaf aaaqmqqmaa lnmnglaaap
      301 mtptsggstp pgitapavps ipspigvngf tglppqangq paaeavfang ihpypaqspt
      361 aadplqqaya gvqqyagpay paaygqisqa fpqpppmipq qqregpegcn lliyhlpqef
      421 gdaelmqmfl pfaapggpve tqalvprvsp gfvsfdnpas aqtaiqamng fqigmkrlkv
      481 qlkrpkdanr py
//
LOCUS       NP_001239405             353 aa            linear   ROD 09-OCT-2023
DEFINITION  protein arginine N-methyltransferase 1 isoform 2 [Mus musculus].
ACCESSION   NP_001239405
VERSION     NP_001239405.1
DBSOURCE    REFSEQ: accession NM_001252476.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 353)
  AUTHORS   Ye H, Cao L, Jackson-Weaver O, Zheng L and Gou Y.
  TITLE     PRMT1-mediated arginine methylation promotes postnatal calvaria
            bone formation through BMP-Smad signaling
  JOURNAL   Bone 176, 116887 (2023)
   PUBMED   37634683
  REMARK    GeneRIF: PRMT1-mediated arginine methylation promotes postnatal
            calvaria bone formation through BMP-Smad signaling.
REFERENCE   2  (residues 1 to 353)
  AUTHORS   Zhu Y, Wang L, Liu R, Ding X, Yin S, Chen Y, Zhu C, Wang Z and Li
            W.
  TITLE     Inhibition of PRMT1 alleviates sepsis-induced acute kidney injury
            in mice by blocking the TGF-beta1 and IL-6 trans-signaling pathways
  JOURNAL   FEBS Open Bio 13 (10), 1859-1873 (2023)
   PUBMED   37525933
  REMARK    GeneRIF: Inhibition of PRMT1 alleviates sepsis-induced acute kidney
            injury in mice by blocking the TGF-beta1 and IL-6 trans-signaling
            pathways.
REFERENCE   3  (residues 1 to 353)
  AUTHORS   Litzler LC, Zahn A, Dionne KL, Sprumont A, Ferreira SR, Slattery
            MRF, Methot SP, Patenaude AM, Hebert S, Kabir N, Subramani PG, Jung
            S, Richard S, Kleinman CL and Di Noia JM.
  TITLE     Protein arginine methyltransferase 1 regulates B cell fate after
            positive selection in the germinal center in mice
  JOURNAL   J Exp Med 220 (9) (2023)
   PUBMED   37310381
  REMARK    GeneRIF: Protein arginine methyltransferase 1 regulates B cell fate
            after positive selection in the germinal center in mice.
REFERENCE   4  (residues 1 to 353)
  AUTHORS   Li Q, Jiao J, Heng Y, Lu Q, Zheng Y, Li H, Cai J, Mei M and Bao S.
  TITLE     Prmt5 promotes ciliated cell specification of airway epithelial
            progenitors via transcriptional inhibition of Tp63
  JOURNAL   J Biol Chem 299 (8), 104964 (2023)
   PUBMED   37364687
REFERENCE   5  (residues 1 to 353)
  AUTHORS   Liu J, Bu X, Chu C, Dai X, Asara JM, Sicinski P, Freeman GJ and Wei
            W.
  TITLE     PRMT1 mediated methylation of cGAS suppresses anti-tumor immunity
  JOURNAL   Nat Commun 14 (1), 2806 (2023)
   PUBMED   37193698
  REMARK    GeneRIF: PRMT1 mediated methylation of cGAS suppresses anti-tumor
            immunity.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 353)
  AUTHORS   Cimato TR, Tang J, Xu Y, Guarnaccia C, Herschman HR, Pongor S and
            Aletta JM.
  TITLE     Nerve growth factor-mediated increases in protein methylation occur
            predominantly at type I arginine methylation sites and involve
            protein arginine methyltransferase 1
  JOURNAL   J Neurosci Res 67 (4), 435-442 (2002)
   PUBMED   11835310
  REMARK    GeneRIF: Type I protein arginine methyltransferase (PRMT) activity
            produces asymmetric dimethylation of the terminal guanidinonitrogen
            of arginines in substrate proteins, particularly glycine and
            arginine-rich (GAR) segments of proteins
REFERENCE   7  (residues 1 to 353)
  AUTHORS   Pawlak MR, Scherer CA, Chen J, Roshon MJ and Ruley HE.
  TITLE     Arginine N-methyltransferase 1 is required for early
            postimplantation mouse development, but cells deficient in the
            enzyme are viable
  JOURNAL   Mol Cell Biol 20 (13), 4859-4869 (2000)
   PUBMED   10848611
REFERENCE   8  (residues 1 to 353)
  AUTHORS   Brady KP, Rowe LB, Her H, Stevens TJ, Eppig J, Sussman DJ, Sikela J
            and Beier DR.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
REFERENCE   9  (residues 1 to 353)
  AUTHORS   Scherer CA, Chen J, Nachabeh A, Hopkins N and Ruley HE.
  TITLE     Transcriptional specificity of the pluripotent embryonic stem cell
  JOURNAL   Cell Growth Differ 7 (10), 1393-1401 (1996)
   PUBMED   8891343
REFERENCE   10 (residues 1 to 353)
  AUTHORS   Lin WJ, Gary JD, Yang MC, Clarke S and Herschman HR.
  TITLE     The mammalian immediate-early TIS21 protein and the
            leukemia-associated BTG1 protein interact with a protein-arginine
            N-methyltransferase
  JOURNAL   J Biol Chem 271 (25), 15034-15044 (1996)
   PUBMED   8663146
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU524421.1, AK152342.1, BY760714.1 and AI846916.1.
            
            Transcript Variant: This variant (2) lacks an alternate exon in the
            5' coding region, compared to variant 1. The resulting protein
            (isoform 2) is shorter when it is compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK152342.1, AK146927.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..353
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 29.07 cM"
     Protein         1..353
                     /product="protein arginine N-methyltransferase 1 isoform
                     2"
                     /EC_number="2.1.1.319"
                     /note="arginine N-methyltransferase 1; histone-arginine
                     N-methyltransferase PRMT1; heterogeneous nuclear
                     ribonucleoproteins methyltransferase-like 2"
                     /calculated_mol_wt=40391
     Region          74..174
                     /region_name="AdoMet_MTases"
                     /note="S-adenosylmethionine-dependent methyltransferases
                     (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes
                     that use S-adenosyl-L-methionine (SAM or AdoMet) as a
                     substrate for methyltransfer, creating the product
                     S-adenosyl-L-homocysteine (AdoHcy); cd02440"
                     /db_xref="CDD:100107"
     Site            order(77..83,100,104,126..128,145)
                     /site_type="other"
                     /note="S-adenosylmethionine binding site [chemical
                     binding]"
                     /db_xref="CDD:100107"
     CDS             1..353
                     /gene="Prmt1"
                     /gene_synonym="6720434D09Rik; Hrmt1l2; Mrmt1"
                     /coded_by="NM_001252476.1:103..1164"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS57547.1"
                     /db_xref="GeneID:15469"
                     /db_xref="MGI:MGI:107846"
ORIGIN      
        1 maaaeaanci mevscgqaes sekpnaedmt skdyyfdsya hfgiheemlk devrtltyrn
       61 smfhnrhlfk dkvvldvgsg tgilcmfaak agarkvigie cssisdyavk ivkankldhv
      121 vtiikgkvee velpvekvdi iisewmgycl fyesmlntvl hardkwlapd glifpdratl
      181 yvtaiedrqy kdykihwwen vygfdmscik dvaikeplvd vvdpkqlvtn aclikevdiy
      241 tvkvedltft spfclqvkrn dyvhalvayf nieftrchkr tgfstspesp ythwkqtvfy
      301 medyltvktg eeifgtigmr pnaknnrdld ftidldfkgq lcelscstdy rmr
//
LOCUS       NP_067336                507 aa            linear   ROD 09-OCT-2023
DEFINITION  RNA-binding protein Nova-1 isoform 1 [Mus musculus].
ACCESSION   NP_067336 XP_001472308 XP_001472341 XP_001472371 XP_917587
            XP_927504
VERSION     NP_067336.1
DBSOURCE    REFSEQ: accession NM_021361.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 507)
  AUTHORS   Tajima Y, Ito K, Yuan Y, Frank MO, Saito Y and Darnell RB.
  TITLE     NOVA1 acts on Impact to regulate hypothalamic function and
            translation in inhibitory neurons
  JOURNAL   Cell Rep 42 (2), 112050 (2023)
   PUBMED   36716149
  REMARK    GeneRIF: NOVA1 acts on Impact to regulate hypothalamic function and
            translation in inhibitory neurons.
REFERENCE   2  (residues 1 to 507)
  AUTHORS   Brahma MK, Xiao P, Popa M, Negueruela J, Vandenbempt V, Demine S,
            Cardozo AK and Gurzov EN.
  TITLE     Nova1 or Bim Deficiency in Pancreatic beta-Cells Does Not Alter
            Multiple Low-Dose Streptozotocin-Induced Diabetes and Diet-Induced
            Obesity in Mice
  JOURNAL   Nutrients 14 (18), 3866 (2022)
   PUBMED   36145242
  REMARK    GeneRIF: Nova1 or Bim Deficiency in Pancreatic beta-Cells Does Not
            Alter Multiple Low-Dose Streptozotocin-Induced Diabetes and
            Diet-Induced Obesity in Mice.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 507)
  AUTHORS   Krach F, Wheeler EC, Regensburger M, Boerstler T, Wend H, Vu AQ,
            Wang R, Reischl S, Boldt K, Batra R, Aigner S, Ravits J, Winkler J,
            Yeo GW and Winner B.
  TITLE     Aberrant NOVA1 function disrupts alternative splicing in early
            stages of amyotrophic lateral sclerosis
  JOURNAL   Acta Neuropathol 144 (3), 413-435 (2022)
   PUBMED   35778567
  REMARK    GeneRIF: Aberrant NOVA1 function disrupts alternative splicing in
            early stages of amyotrophic lateral sclerosis.
REFERENCE   4  (residues 1 to 507)
  AUTHORS   Li D, Shen M, Deng X and Bai Y.
  TITLE     MicroRNA miR-27a-3p accelerates cardiac hypertrophy by targeting
            neuro-oncological ventral antigen 1
  JOURNAL   Bioengineered 13 (4), 8982-8993 (2022)
   PUBMED   35348441
  REMARK    GeneRIF: MicroRNA miR-27a-3p accelerates cardiac hypertrophy by
            targeting neuro-oncological ventral antigen 1.
REFERENCE   5  (residues 1 to 507)
  AUTHORS   Johnson V, Junge HJ and Chen Z.
  TITLE     Temporal regulation of axonal repulsion by alternative splicing of
            a conserved microexon in mammalian Robo1 and Robo2
  JOURNAL   Elife 8, e46042 (2019)
   PUBMED   31392959
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 507)
  AUTHORS   Jensen KB, Dredge BK, Stefani G, Zhong R, Buckanovich RJ, Okano HJ,
            Yang YY and Darnell RB.
  TITLE     Nova-1 regulates neuron-specific alternative splicing and is
            essential for neuronal viability
  JOURNAL   Neuron 25 (2), 359-371 (2000)
   PUBMED   10719891
REFERENCE   7  (residues 1 to 507)
  AUTHORS   Yang YY, Yin GL and Darnell RB.
  TITLE     The neuronal RNA-binding protein Nova-2 is implicated as the
            autoantigen targeted in POMA patients with dementia
  JOURNAL   Proc Natl Acad Sci U S A 95 (22), 13254-13259 (1998)
   PUBMED   9789075
REFERENCE   8  (residues 1 to 507)
  AUTHORS   Fletcher CF, Okano HJ, Gilbert DJ, Yang Y, Yang C, Copeland NG,
            Jenkins NA and Darnell RB.
  TITLE     Mouse chromosomal locations of nine genes encoding homologs of
            human paraneoplastic neurologic disorder antigens
  JOURNAL   Genomics 45 (2), 313-319 (1997)
   PUBMED   9344654
REFERENCE   9  (residues 1 to 507)
  AUTHORS   Buckanovich RJ and Darnell RB.
  TITLE     The neuronal RNA binding protein Nova-1 recognizes specific RNA
            targets in vitro and in vivo
  JOURNAL   Mol Cell Biol 17 (6), 3194-3201 (1997)
   PUBMED   9154818
REFERENCE   10 (residues 1 to 507)
  AUTHORS   Buckanovich RJ, Yang YY and Darnell RB.
  TITLE     The onconeural antigen Nova-1 is a neuron-specific RNA-binding
            protein, the activity of which is inhibited by paraneoplastic
            antibodies
  JOURNAL   J Neurosci 16 (3), 1114-1122 (1996)
   PUBMED   8558240
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM942596.1, AW491473.1, AC108802.15 and CT009504.11.
            
            On or before Aug 20, 2009 this sequence version replaced
            XP_917587.1, XP_927504.1, XP_001472308.1, XP_001472341.1,
            XP_001472371.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF232828.1, SRR6116558.152448.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164136
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..507
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 21.46 cM"
     Protein         1..507
                     /product="RNA-binding protein Nova-1 isoform 1"
                     /note="RNA-binding protein Nova-1; ventral neuron-specific
                     protein 1; neuro-oncological ventral antigen 1"
                     /calculated_mol_wt=51625
     Region          1..44
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKN6.2)"
     Region          27..43
                     /region_name="Bipartite nuclear localization signal.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKN6.2)"
     Region          49..121
                     /region_name="KH-I_NOVA_rpt1"
                     /note="first type I K homology (KH) RNA-binding domain
                     found in the family of neuro-oncological ventral antigen
                     (Nova); cd22435"
                     /db_xref="CDD:411863"
     Site            order(61..63,65..69,72..73,83..85,87..89,98)
                     /site_type="other"
                     /note="RNA binding site [nucleotide binding]"
                     /db_xref="CDD:411863"
     Region          139..171
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKN6.2)"
     Site            154
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:15933722; propagated from
                     UniProtKB/Swiss-Prot (Q9JKN6.2)"
     Region          172..241
                     /region_name="KH-I_NOVA_rpt2"
                     /note="second type I K homology (KH) RNA-binding domain
                     found in the family of neuro-oncological ventral antigen
                     (Nova); cd22436"
                     /db_xref="CDD:411864"
     Site            order(183..185,187..191,194..195,205..207,209..211,219)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:411864"
     Region          419..503
                     /region_name="Required for RNA binding.
                     /evidence=ECO:0000250|UniProtKB:P51513"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKN6.2)"
     Region          422..492
                     /region_name="KH-I_NOVA_rpt3"
                     /note="third type I K homology (KH) RNA-binding domain
                     found in the family of neuro-oncological ventral antigen
                     (Nova); cd09031"
                     /db_xref="CDD:411807"
     Site            order(430..431,433..435,437..441,444..445,455..461,463,
                     468,470)
                     /site_type="other"
                     /note="RNA binding site [nucleotide binding]"
                     /db_xref="CDD:411807"
     CDS             1..507
                     /gene="Nova1"
                     /gene_synonym="9430099M15Rik; G630039L02; Nova-1"
                     /coded_by="NM_021361.2:17..1540"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS49058.1"
                     /db_xref="GeneID:664883"
                     /db_xref="MGI:MGI:104297"
ORIGIN      
        1 mmaaapiqqn gthtgvpidl dppdsrkrpl eappeagstk rtntgedgqy flkvlipsya
       61 agsiigkggq tivqlqketg atiklskskd fypgttervc liqgtiealn avhgfiaeki
      121 rempqnvakt epvsilqpqt tvnpdrikqt lpssptttks spsdpmttsr anqvkiivpn
      181 stagliigkg gatvkaimeq sgawvqlsqk pdginlqerv vtvsgepeqn rkaveliiqk
      241 iqedpqsgsc lnisyanvtg pvansnptgs pyantaevlp taaaaagllg hanlagvaaf
      301 pavlsgftgn dlvaitsaln tlasygynln tlglglsqaa atgalaaaaa sanpaaaaan
      361 llatyaseas asgstaggta gtfalgslaa ataatngyfg aasplaasai lgtekstdgs
      421 kdvveiavpe nlvgailgkg gktlveyqel tgariqiskk gefvpgtrnr kvtitgtpaa
      481 tqaaqylitq rityeqgvra anpqkvg
//
LOCUS       NP_001295195             748 aa            linear   ROD 09-OCT-2023
DEFINITION  signal transducer and activator of transcription 4 [Mus musculus].
ACCESSION   NP_001295195
VERSION     NP_001295195.1
DBSOURCE    REFSEQ: accession NM_001308266.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 748)
  AUTHORS   Zhang XL, Hollander CM, Khan MY, D'silva M, Ma H, Yang X, Bai R,
            Keeter CK, Galkina EV, Nadler JL and Stanton PK.
  TITLE     Myeloid cell deficiency of the inflammatory transcription factor
            Stat4 protects long-term synaptic plasticity from the effects of a
            high-fat, high-cholesterol diet
  JOURNAL   Commun Biol 6 (1), 967 (2023)
   PUBMED   37783748
  REMARK    GeneRIF: Myeloid cell deficiency of the inflammatory transcription
            factor Stat4 protects long-term synaptic plasticity from the
            effects of a high-fat, high-cholesterol diet.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 748)
  AUTHORS   Keeter WC, Moriarty AK, Akers R, Ma S, Mussbacher M, Nadler JL and
            Galkina EV.
  TITLE     Neutrophil-specific STAT4 deficiency attenuates atherosclerotic
            burden and improves plaque stability via reduction in neutrophil
            activation and recruitment into aortas of Ldlr-/- mice
  JOURNAL   Front Cardiovasc Med 10, 1175673 (2023)
   PUBMED   37396582
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 748)
  AUTHORS   Buzzelli AA, McWilliams IL, Shin B, Bryars MT and Harrington LE.
  TITLE     Intrinsic STAT4 Expression Controls Effector CD4 T Cell Migration
            and Th17 Pathogenicity
  JOURNAL   J Immunol 210 (11), 1667-1676 (2023)
   PUBMED   37093664
REFERENCE   4  (residues 1 to 748)
  AUTHORS   Hildreth AD, Padilla ET, Tafti RY, Legala AR and O'Sullivan TE.
  TITLE     Sterile liver injury induces a protective tissue-resident cDC1-ILC1
            circuit through cDC1-intrinsic cGAS-STING-dependent IL-12
            production
  JOURNAL   Cell Rep 42 (2), 112141 (2023)
   PUBMED   36807146
REFERENCE   5  (residues 1 to 748)
  AUTHORS   Liang Y, Pan HF and Ye DQ.
  TITLE     Therapeutic potential of STAT4 in autoimmunity
  JOURNAL   Expert Opin Ther Targets 18 (8), 945-960 (2014)
   PUBMED   24844303
  REMARK    Review article
REFERENCE   6  (residues 1 to 748)
  AUTHORS   Wang Y, Feng D, Wang H, Xu MJ, Park O, Li Y and Gao B.
  TITLE     STAT4 knockout mice are more susceptible to concanavalin A-induced
            T-cell hepatitis
  JOURNAL   Am J Pathol 184 (6), 1785-1794 (2014)
   PUBMED   24731448
REFERENCE   7  (residues 1 to 748)
  AUTHORS   Copeland NG, Gilbert DJ, Schindler C, Zhong Z, Wen Z, Darnell JE
            Jr, Mui AL, Miyajima A, Quelle FW, Ihle JN et al.
  TITLE     Distribution of the mammalian Stat gene family in mouse chromosomes
  JOURNAL   Genomics 29 (1), 225-228 (1995)
   PUBMED   8530075
REFERENCE   8  (residues 1 to 748)
  AUTHORS   Yamamoto K, Quelle FW, Thierfelder WE, Kreider BL, Gilbert DJ,
            Jenkins NA, Copeland NG, Silvennoinen O and Ihle JN.
  TITLE     Stat4, a novel gamma interferon activation site-binding protein
            expressed in early myeloid differentiation
  JOURNAL   Mol Cell Biol 14 (7), 4342-4349 (1994)
   PUBMED   8007943
REFERENCE   9  (residues 1 to 748)
  AUTHORS   Zhong Z, Wen Z and Darnell JE Jr.
  TITLE     Stat3 and Stat4: members of the family of signal transducers and
            activators of transcription
  JOURNAL   Proc Natl Acad Sci U S A 91 (11), 4806-4810 (1994)
   PUBMED   7545930
REFERENCE   10 (residues 1 to 748)
  AUTHORS   Zhong Z, Wen Z and Darnell JE Jr.
  TITLE     Stat3: a STAT family member activated by tyrosine phosphorylation
            in response to epidermal growth factor and interleukin-6
  JOURNAL   Science 264 (5155), 95-98 (1994)
   PUBMED   8140422
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK132675.1 and BF020635.1.
            
            Summary: The protein encoded by this gene is a member of the STAT
            family of transcription factors. In response to cytokines and
            growth factors, STAT family members are phosphorylated by the
            receptor associated kinases, and then form homo- or heterodimers
            that translocate to the cell nucleus where they act as
            transcription activators. Homozygous knockout mice for this gene
            exhibit reduced inflammation and cytokine production in response to
            immune challenge. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Apr 2015].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132675.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..748
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 26.67 cM"
     Protein         1..748
                     /product="signal transducer and activator of transcription
                     4"
                     /calculated_mol_wt=85723
     Region          2..121
                     /region_name="STAT_int"
                     /note="STAT protein, protein interaction domain;
                     smart00964"
                     /db_xref="CDD:214942"
     Region          140..312
                     /region_name="STAT4_CCD"
                     /note="Coiled-coil domain of Signal Transducer and
                     Activator of Transcription 4 (STAT4); cd16854"
                     /db_xref="CDD:341079"
     Site            order(141..164,208..234,258..279)
                     /site_type="other"
                     /note="coiled-coil motif"
                     /db_xref="CDD:341079"
     Region          316..473
                     /region_name="STAT4_DBD"
                     /note="DNA-binding domain of Signal Transducer and
                     Activator of Transcription 4 (STAT4); cd16848"
                     /db_xref="CDD:341086"
     Region          553..700
                     /region_name="SH2_STAT4"
                     /note="Src homology 2 (SH2) domain found in signal
                     transducer and activator of transcription (STAT)
                     4proteins; cd10375"
                     /db_xref="CDD:198238"
     Site            order(580,598,624,626)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198238"
     Site            order(625,641)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198238"
     Site            order(635..636,698)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:198238"
     Site            667
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q14765; propagated from
                     UniProtKB/Swiss-Prot (P42228.1)"
     Site            693
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by JAK.
                     /evidence=ECO:0000250|UniProtKB:Q14765; propagated from
                     UniProtKB/Swiss-Prot (P42228.1)"
     Site            721
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q14765; propagated from
                     UniProtKB/Swiss-Prot (P42228.1)"
     CDS             1..748
                     /gene="Stat4"
                     /coded_by="NM_001308266.1:163..2409"
                     /db_xref="CCDS:CCDS14943.1"
                     /db_xref="GeneID:20849"
                     /db_xref="MGI:MGI:103062"
ORIGIN      
        1 msqwnqvqql eikfleqvdq fyddnfpmei rhllaqwiet qdwevasnne tmatillqnl
       61 liqldeqlgr vskeknllli hnlkrirkvl qgkfhgnpmh vavvisnclr eerrilaaan
      121 mpiqgpleks lqsssvserq rnvehkvsai knsvqmteqd tkyledlqde fdyryktiqt
      181 mdqgdknsil vnqevltlqe mlnsldfkrk ealskmtqiv netdllmnsm lleelqdwkk
      241 rqqiaciggp lhngldqlqn cftllaeslf qlrqqleklq eqstkmtyeg dpipaqrahl
      301 leratfliyn lfknsfvver qpcmpthpqr pmvlktliqf tvklrllikl pelnyqvkvk
      361 asidknvstl snrrfvlcgt hvkamssees sngslsvefr hlqpkemkcs tgskgnegch
      421 mvteelhsit fetqiclygl tinletsslp vvmisnvsql pnawasiiwy nvstndsqnl
      481 vffnnppsvt lgqllevmsw qfssyvgrgl nseqlnmlae kltvqsnynd ghltwakfck
      541 ehlpgktftf wtwleaildl ikkhilplwi dgyimgfvsk ekerlllkdk mpgtfllrfs
      601 eshlggitft wvdqsengev rfhsvepynk grlsalpfad ilrdykvima enipenplky
      661 lypdipkdka fgkhyssqpc evsrptergd kgyvpsvfip istirsdste pqspsdllpm
      721 spsayavlre nlspttieta mnspysae
//
LOCUS       NP_001349231             500 aa            linear   ROD 09-OCT-2023
DEFINITION  CUGBP Elav-like family member 4 isoform 26 [Mus musculus].
ACCESSION   NP_001349231
VERSION     NP_001349231.1
DBSOURCE    REFSEQ: accession NM_001362302.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 500)
  AUTHORS   Salamon I, Park Y, Miskic T, Kopic J, Matteson P, Page NF, Roque A,
            McAuliffe GW, Favate J, Garcia-Forn M, Shah P, Judas M, Millonig
            JH, Kostovic I, De Rubeis S, Hart RP, Krsnik Z and Rasin MR.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    GeneRIF: Celf4 controls mRNA translation underlying synaptic
            development in the prenatal mammalian neocortex.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 500)
  AUTHORS   Shen Y, Zhang C, Xiao K, Liu D and Xie G.
  TITLE     CELF4 regulates spine formation and depression-like behaviors of
            mice
  JOURNAL   Biochem Biophys Res Commun 605, 39-44 (2022)
   PUBMED   35306363
  REMARK    GeneRIF: CELF4 regulates spine formation and depression-like
            behaviors of mice.
REFERENCE   3  (residues 1 to 500)
  AUTHORS   Moreau MX, Saillour Y, Cwetsch AW, Pierani A and Causeret F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   4  (residues 1 to 500)
  AUTHORS   Li C, Li X, Bi Z, Sugino K, Wang G, Zhu T and Liu Z.
  TITLE     Comprehensive transcriptome analysis of cochlear spiral ganglion
            neurons at multiple ages
  JOURNAL   Elife 9, e50491 (2020)
   PUBMED   31913118
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 500)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 500)
  AUTHORS   Ladd AN, Taffet G, Hartley C, Kearney DL and Cooper TA.
  TITLE     Cardiac tissue-specific repression of CELF activity disrupts
            alternative splicing and causes cardiomyopathy
  JOURNAL   Mol Cell Biol 25 (14), 6267-6278 (2005)
   PUBMED   15988035
  REMARK    GeneRIF: CELF protein activity is required for normal alternative
            splicing in the heart in vivo and normal CELF-mediated alternative
            splicing regulation is in turn required for normal cardiac
            function.
REFERENCE   7  (residues 1 to 500)
  AUTHORS   Meins M, Schlickum S, Wilhelm C, Missbach J, Yadav S, Glaser B,
            Grzmil M, Burfeind P and Laccone F.
  TITLE     Identification and characterization of murine Brunol4, a new member
            of the elav/bruno family
  JOURNAL   Cytogenet Genome Res 97 (3-4), 254-260 (2002)
   PUBMED   12438720
  REMARK    GeneRIF: cloning and characterization
REFERENCE   8  (residues 1 to 500)
  AUTHORS   Ladd AN, Charlet N and Cooper TA.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   9  (residues 1 to 500)
  AUTHORS   Good PJ, Chen Q, Warner SJ and Herring DC.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
REFERENCE   10 (residues 1 to 500)
  AUTHORS   Yulug IG, Egan SE, See CG and Fisher EM.
  TITLE     Mapping GRB2, a signal transduction gene in the human and the mouse
  JOURNAL   Genomics 22 (2), 313-318 (1994)
   PUBMED   7806216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121094.8 and AC144938.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.26101.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 13.92 cM"
     Protein         1..500
                     /product="CUGBP Elav-like family member 4 isoform 26"
                     /note="CUG-BP- and ETR-3-like factor 4; bruno-like protein
                     4; RNA-binding protein BRUNOL-4; bruno-like 4, RNA binding
                     protein"
                     /calculated_mol_wt=53328
     Region          49..135
                     /region_name="RRM1_CELF3_4_5_6"
                     /note="RNA recognition motif 1 (RRM1) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12632"
                     /db_xref="CDD:410041"
     Site            order(55,57,59..60,63,82,84,86,95..97,99,129,131)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410041"
     Region          140..226
                     /region_name="RRM2_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12635"
                     /db_xref="CDD:410043"
     Site            order(142,144,146..147,150,169,171,173,181..183,185,221,
                     223)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410043"
     Region          411..489
                     /region_name="RRM3_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12639"
                     /db_xref="CDD:241083"
     CDS             1..500
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /coded_by="NM_001362302.1:531..2033"
                     /note="isoform 26 is encoded by transcript variant 31"
                     /db_xref="GeneID:108013"
                     /db_xref="MGI:MGI:1932407"
ORIGIN      
        1 myikmatlan gqadnaslst nglgsspgsa ghmnglshsp gnpstipmkd hdaiklfigq
       61 iprnldekdl kplfeefgki yeltvlkdrf tgmhkgcafl tyceresalk aqsalheqkt
      121 lpgmnrpiqv kpadsesrgd rklfvgmlnk qqseddvrrl feafgnieec tilrgpdgns
      181 kgcafvkyss haeaqaaina lhgsqtmpvs vtlggasssl vvkfadtdke rtmrrmqqma
      241 gqmgmfnpma ipfgaygaya qalmqqqaal masvaqggyl npmaafaaaq mqqmaalnmn
      301 glaaapmtpt sggstppgit apavpsipsp igvngftglp pqangqpaae avfangihpy
      361 paqsptaadp lqqayagvqq yagpaypaay gqisqafpqp ppmipqqqre gpegcnlliy
      421 hlpqefgdae lmqmflpfgn visskvfvdr atnqskcfgf vsfdnpasaq taiqamngfq
      481 igmkrlkvql krpkdanrpy
//
LOCUS       NP_001397156             515 aa            linear   ROD 09-OCT-2023
DEFINITION  nuclear respiratory factor 1 isoform f [Mus musculus].
ACCESSION   NP_001397156 XP_011239350
VERSION     NP_001397156.1
DBSOURCE    REFSEQ: accession NM_001410227.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 515)
  AUTHORS   Cheng C, Tian Y, Yang R, Guo W, Xiao K, Zhang F, Tian J, Deng Z,
            Yang W, Yang H and Zhou Z.
  TITLE     miR-5581 Contributes to Osteoarthritis by Targeting NRF1 to Disturb
            the Proliferation and Functions of Chondrocytes
  JOURNAL   Am J Pathol 193 (9), 1234-1247 (2023)
   PUBMED   37611970
  REMARK    GeneRIF: miR-5581 Contributes to Osteoarthritis by Targeting NRF1
            to Disturb the Proliferation and Functions of Chondrocytes.
REFERENCE   2  (residues 1 to 515)
  AUTHORS   Meng Z, Liang B, Wu Y, Liu C, Wang H, Du Y, Gan L, Gao E, Lau WB,
            Christopher TA, Lopez BL, Koch WJ, Ma X, Zhao F, Wang Y and Zhao J.
  TITLE     Hypoadiponectinemia-induced upregulation of microRNA449b
            downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury
            in diabetic mice
  JOURNAL   J Mol Cell Cardiol 182, 1-14 (2023)
   PUBMED   37437402
  REMARK    GeneRIF: Hypoadiponectinemia-induced upregulation of microRNA449b
            downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury
            in diabetic mice.
REFERENCE   3  (residues 1 to 515)
  AUTHORS   Zhao T, Zhang J, Lei H, Meng Y, Cheng H, Zhao Y, Geng G, Mu C, Chen
            L, Liu Q, Luo Q, Zhang C, Long Y, Su J, Wang Y, Li Z, Sun J, Chen
            G, Li Y, Liao X, Shang Y, Hu G, Chen Q and Zhu Y.
  TITLE     NRF1-mediated mitochondrial biogenesis antagonizes innate antiviral
            immunity
  JOURNAL   EMBO J 42 (16), e113258 (2023)
   PUBMED   37409632
  REMARK    GeneRIF: NRF1-mediated mitochondrial biogenesis antagonizes innate
            antiviral immunity.
REFERENCE   4  (residues 1 to 515)
  AUTHORS   Akl MG, Baccetto R, Stebbings BM, Li L and Widenmaier SB.
  TITLE     Euglycemia is affected by stress defense factor hepatocyte NRF1,
            but not NRF2
  JOURNAL   Biochem Biophys Res Commun 668, 96-103 (2023)
   PUBMED   37245295
  REMARK    GeneRIF: Euglycemia is affected by stress defense factor hepatocyte
            NRF1, but not NRF2.
REFERENCE   5  (residues 1 to 515)
  AUTHORS   Akl MG, Li L, Baccetto R, Phanse S, Zhang Q, Trites MJ, McDonald S,
            Aoki H, Babu M and Widenmaier SB.
  TITLE     Complementary gene regulation by NRF1 and NRF2 protects against
            hepatic cholesterol overload
  JOURNAL   Cell Rep 42 (4), 112399 (2023)
   PUBMED   37060561
  REMARK    GeneRIF: Complementary gene regulation by NRF1 and NRF2 protects
            against hepatic cholesterol overload.
            Erratum:[Cell Rep. 2023 Jul 25;42(7):112872. PMID: 37454293]
REFERENCE   6  (residues 1 to 515)
  AUTHORS   Carmona MC, Iglesias R, Obregon MJ, Darlington GJ, Villarroya F and
            Giralt M.
  TITLE     Mitochondrial biogenesis and thyroid status maturation in brown fat
            require CCAAT/enhancer-binding protein alpha
  JOURNAL   J Biol Chem 277 (24), 21489-21498 (2002)
   PUBMED   11940593
REFERENCE   7  (residues 1 to 515)
  AUTHORS   Huo L and Scarpulla RC.
  TITLE     Mitochondrial DNA instability and peri-implantation lethality
            associated with targeted disruption of nuclear respiratory factor 1
            in mice
  JOURNAL   Mol Cell Biol 21 (2), 644-654 (2001)
   PUBMED   11134350
REFERENCE   8  (residues 1 to 515)
  AUTHORS   Schaefer L, Engman H and Miller JB.
  TITLE     Coding sequence, chromosomal localization, and expression pattern
            of Nrf1: the mouse homolog of Drosophila erect wing
  JOURNAL   Mamm Genome 11 (2), 104-110 (2000)
   PUBMED   10656923
REFERENCE   9  (residues 1 to 515)
  AUTHORS   Huo L and Scarpulla RC.
  TITLE     Multiple 5'-untranslated exons in the nuclear respiratory factor 1
            gene span 47 kb and contribute to transcript heterogeneity and
            translational efficiency
  JOURNAL   Gene 233 (1-2), 213-224 (1999)
   PUBMED   10375638
REFERENCE   10 (residues 1 to 515)
  AUTHORS   Virbasius CA, Virbasius JV and Scarpulla RC.
  TITLE     NRF-1, an activator involved in nuclear-mitochondrial interactions,
            utilizes a new DNA-binding domain conserved in a family of
            developmental regulators
  JOURNAL   Genes Dev 7 (12A), 2431-2445 (1993)
   PUBMED   8253388
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134897.4 and AC153632.2.
            
            On Aug 1, 2022 this sequence version replaced XP_011239350.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422600.1080274.1,
                                           SRR13422598.696525.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..515
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 12.47 cM"
     Protein         1..515
                     /product="nuclear respiratory factor 1 isoform f"
                     /note="NRF-1; alpha-pal; alpha palindromic-binding
                     protein"
                     /calculated_mol_wt=54726
     Region          87..295
                     /region_name="Nrf1_DNA-bind"
                     /note="NLS-binding and DNA-binding and dimerization
                     domains of Nrf1; pfam10491"
                     /db_xref="CDD:402218"
     Region          462..514
                     /region_name="Nrf1_activ_bdg"
                     /note="Nrf1 activator activation site binding domain;
                     pfam10492"
                     /db_xref="CDD:431313"
     CDS             1..515
                     /gene="Nrf1"
                     /gene_synonym="D6Ertd415e"
                     /coded_by="NM_001410227.1:274..1821"
                     /note="isoform f is encoded by transcript variant 17"
                     /db_xref="GeneID:18181"
                     /db_xref="MGI:MGI:1332235"
ORIGIN      
        1 meehgvtqte hmatieahav aqqvqqvhva tytehsmlsa dedspssped tsyddsdiln
       61 staadevtah laaavlgikp rashilgpvg maaaaavatg kkrkrphvfe snpsirkrqq
      121 trllrklrat ldeyttrvgq qaivlcisps kpnpvfkvfg aaplenvvrk yksmiledle
      181 salaehapap qevnselppl tidgipvsvd kmtqaqlraf ipemlkystg rgkpgwgkes
      241 ckpiwwpedi pwanvrsdvr teeqkqrvsw tqalrtivkn cykqhgredl lyafedqqtq
      301 tqattthsia hlvpsqtvvq tfsnpdgtvs liqvgtgatv atladaselp ttvtvaqvny
      361 savadgeveq nwatlqggem tiqttqasea tqavaslaea avaasqemqq gatvtmalns
      421 eaaahavatl aeatlqgggq ivlsgetaaa vgaltgvqda nglvqipvsm yqtvvtslaq
      481 gngpvqvama pvttrisdsa vtmdgqavev vtleq
//
LOCUS       NP_064393               2549 aa            linear   ROD 09-OCT-2023
DEFINITION  serine/threonine-protein kinase mTOR [Mus musculus].
ACCESSION   NP_064393 XP_207023
VERSION     NP_064393.2
DBSOURCE    REFSEQ: accession NM_020009.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 2549)
  AUTHORS   Chen Y, Dufour CR, Han L, Li T, Xia H and Giguere V.
  TITLE     Hierarchical Phosphorylation of HOXB13 by mTOR Dictates Its
            Activity and Oncogenic Function in Prostate Cancer
  JOURNAL   Mol Cancer Res 21 (10), 1050-1063 (2023)
   PUBMED   37409967
  REMARK    GeneRIF: Hierarchical Phosphorylation of HOXB13 by mTOR Dictates
            Its Activity and Oncogenic Function in Prostate Cancer.
REFERENCE   2  (residues 1 to 2549)
  AUTHORS   Kushima Y, Sato Y, Kobayashi T, Fukuma Y, Matsumoto M, Nakamura M,
            Iwamoto T and Miyamoto T.
  TITLE     TNFalpha-dependent mTOR activity is required for tenotomy-induced
            ectopic ossification in mice
  JOURNAL   J Bone Miner Metab 41 (5), 583-591 (2023)
   PUBMED   37261543
  REMARK    GeneRIF: TNFalpha-dependent mTOR activity is required for
            tenotomy-induced ectopic ossification in mice.
REFERENCE   3  (residues 1 to 2549)
  AUTHORS   Qian C, Lu J, Che X, Min L, Wang M, Song A, Lu R, Gu L and Xie K.
  TITLE     P2X7R/AKT/mTOR signaling mediates high glucose-induced decrease in
            podocyte autophagy
  JOURNAL   Free Radic Biol Med 204, 337-346 (2023)
   PUBMED   37245531
  REMARK    GeneRIF: P2X7R/AKT/mTOR signaling mediates high glucose-induced
            decrease in podocyte autophagy.
REFERENCE   4  (residues 1 to 2549)
  AUTHORS   Shi F and Collins S.
  TITLE     Regulation of mTOR Signaling: Emerging Role of Cyclic
            Nucleotide-Dependent Protein Kinases and Implications for
            Cardiometabolic Disease
  JOURNAL   Int J Mol Sci 24 (14), 11497 (2023)
   PUBMED   37511253
  REMARK    GeneRIF: Regulation of mTOR Signaling: Emerging Role of Cyclic
            Nucleotide-Dependent Protein Kinases and Implications for
            Cardiometabolic Disease.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 2549)
  AUTHORS   Li P, Hao X, Liu J, Zhang Q, Liang Z, Li X and Liu H.
  TITLE     miR-29a-3p Regulates Autophagy by Targeting Akt3-Mediated mTOR in
            SiO2-Induced Lung Fibrosis
  JOURNAL   Int J Mol Sci 24 (14), 11440 (2023)
   PUBMED   37511199
  REMARK    GeneRIF: miR-29a-3p Regulates Autophagy by Targeting Akt3-Mediated
            mTOR in SiO2-Induced Lung Fibrosis.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 2549)
  AUTHORS   Hentges KE, Sirry B, Gingeras AC, Sarbassov D, Sonenberg N,
            Sabatini D and Peterson AS.
  TITLE     FRAP/mTOR is required for proliferation and patterning during
            embryonic development in the mouse
  JOURNAL   Proc Natl Acad Sci U S A 98 (24), 13796-13801 (2001)
   PUBMED   11707573
REFERENCE   7  (residues 1 to 2549)
  AUTHORS   Liu JJ and Wilson SE.
  TITLE     Characterization of human and mouse angiopoietin-like factor CDT6
            promoters
  JOURNAL   Invest Ophthalmol Vis Sci 42 (12), 2776-2783 (2001)
   PUBMED   11687517
REFERENCE   8  (residues 1 to 2549)
  AUTHORS   Hentges K, Thompson K and Peterson A.
  TITLE     The flat-top gene is required for the expansion and regionalization
            of the telencephalic primordium
  JOURNAL   Development 126 (8), 1601-1609 (1999)
   PUBMED   10079223
REFERENCE   9  (residues 1 to 2549)
  AUTHORS   Cohen,J.S.
  TITLE     Provide fluoxetine information vital to clinicians
  JOURNAL   J Clin Psychiatry 56 (12), 591 (1995)
   PUBMED   8530339
REFERENCE   10 (residues 1 to 2549)
  AUTHORS   Chiu MI, Katz H and Berlin V.
  TITLE     RAPT1, a mammalian homolog of yeast Tor, interacts with the
            FKBP12/rapamycin complex
  JOURNAL   Proc Natl Acad Sci U S A 91 (26), 12574-12578 (1994)
   PUBMED   7809080
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ130100.1 and BC112904.1.
            
            On Apr 22, 2009 this sequence version replaced NP_064393.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC112904.1, AF152838.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2549
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 78.76 cM"
     Protein         1..2549
                     /product="serine/threonine-protein kinase mTOR"
                     /EC_number="2.7.11.1"
                     /note="angiopoietin-like factor CDT6; rapamycin target
                     protein 1; mammalian target of rapamycin; FKBP12-rapamycin
                     complex-associated protein; FK506-binding protein
                     12-rapamycin complex-associated protein 1; FK506 binding
                     protein 12-rapamycin associated protein 1; FKBP-rapamycin
                     associated protein (FRAP); mechanistic target of rapamycin
                     (serine/threonine kinase)"
                     /calculated_mol_wt=288660
     Region          1..651
                     /region_name="Interaction with NBN. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JLN9.2)"
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:P42345; propagated from
                     UniProtKB/Swiss-Prot (Q9JLN9.2)"
     Region          363..2549
                     /region_name="TEL1"
                     /note="Phosphatidylinositol kinase or protein kinase, PI-3
                     family [Signal transduction mechanisms]; COG5032"
                     /db_xref="CDD:227365"
     Site            567
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P42345; propagated from
                     UniProtKB/Swiss-Prot (Q9JLN9.2)"
     Region          637..683
                     /region_name="HEAT 16"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JLN9.2)"
     Region          655..681
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          686..724
                     /region_name="HEAT 17"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JLN9.2)"
     Region          691..721
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          727..766
                     /region_name="HEAT 18"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JLN9.2)"
     Region          729..759
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          769..811
                     /region_name="HEAT 19"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JLN9.2)"
     Region          772..805
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          814..853
                     /region_name="HEAT 20"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JLN9.2)"
     Region          817..847
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          857..893
                     /region_name="HEAT 21"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JLN9.2)"
     Region          894..942
                     /region_name="HEAT 22"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JLN9.2)"
     Region          943..988
                     /region_name="HEAT 23"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JLN9.2)"
     Region          955..981
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Site            order(969..970,973,980..981,1010..1011,1014,1017..1018,
                     1021,1050..1051,1054,1057..1058,1061,1091..1092,1095,
                     1098..1099,1133..1134,1137,1140..1141)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293787"
     Region          989..1027
                     /region_name="HEAT 24"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JLN9.2)"
     Region          993..1021
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          1029..1068
                     /region_name="HEAT 25"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JLN9.2)"
     Region          1033..1062
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          1069..1105
                     /region_name="HEAT 26"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JLN9.2)"
     Region          1073..1099
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          1106..1144
                     /region_name="HEAT 27"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JLN9.2)"
     Region          1111..1142
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Region          1145..1188
                     /region_name="HEAT 28"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JLN9.2)"
     Region          1154..1180
                     /region_name="HEAT repeat"
                     /note="HEAT repeat [structural motif]"
                     /db_xref="CDD:293787"
     Site            1162
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P42345; propagated from
                     UniProtKB/Swiss-Prot (Q9JLN9.2)"
     Region          1189..1225
                     /region_name="HEAT 29"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JLN9.2)"
     Site            1218
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P42345; propagated from
                     UniProtKB/Swiss-Prot (Q9JLN9.2)"
     Region          1226..1273
                     /region_name="HEAT 30"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JLN9.2)"
     Site            1261
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:19487463,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9JLN9.2)"
     Region          1274..1311
                     /region_name="HEAT 31"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JLN9.2)"
     Region          1312..1345
                     /region_name="HEAT 32"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JLN9.2)"
     Region          1346..1382
                     /region_name="TPR 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JLN9.2)"
     Region          1383..1408
                     /region_name="TPR 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JLN9.2)"
     Region          1409..1442
                     /region_name="TPR 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JLN9.2)"
     Region          1443..1473
                     /region_name="TPR 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JLN9.2)"
     Region          1474..1507
                     /region_name="TPR 5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JLN9.2)"
     Region          1508..1541
                     /region_name="TPR 6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JLN9.2)"
     Region          1542..1574
                     /region_name="TPR 7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JLN9.2)"
     Region          1575..1614
                     /region_name="TPR 8"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JLN9.2)"
     Region          1615..1649
                     /region_name="TPR 9"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JLN9.2)"
     Region          1650..1693
                     /region_name="TPR 10"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JLN9.2)"
     Region          1694..1731
                     /region_name="TPR 11"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JLN9.2)"
     Region          1732..1786
                     /region_name="TPR 12"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JLN9.2)"
     Region          1787..1846
                     /region_name="TPR 13"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JLN9.2)"
     Region          1825..1867
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JLN9.2)"
     Region          1898..1930
                     /region_name="TPR 14"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JLN9.2)"
     Region          1931..1970
                     /region_name="TPR 15"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JLN9.2)"
     Region          1971..2005
                     /region_name="TPR 16"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JLN9.2)"
     Region          2012..2144
                     /region_name="Sufficient for interaction with the
                     FKBP1A/rapamycin complex"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JLN9.2)"
     Site            2159
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P42345; propagated from
                     UniProtKB/Swiss-Prot (Q9JLN9.2)"
     Region          2162..2168
                     /region_name="G-loop.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00269"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JLN9.2)"
     Site            2164
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P42345; propagated from
                     UniProtKB/Swiss-Prot (Q9JLN9.2)"
     Site            2173
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by PKB/AKT1.
                     /evidence=ECO:0000250|UniProtKB:P42345; propagated from
                     UniProtKB/Swiss-Prot (Q9JLN9.2)"
     Region          2258..2296
                     /region_name="Interaction with MLST8.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JLN9.2)"
     Region          2335..2343
                     /region_name="Catalytic loop.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00269"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JLN9.2)"
     Region          2355..2380
                     /region_name="Activation loop.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00269"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JLN9.2)"
     Site            2446
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by RPS6KB1.
                     /evidence=ECO:0000250|UniProtKB:P42345; propagated from
                     UniProtKB/Swiss-Prot (Q9JLN9.2)"
     Site            2448
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by RPS6KB1.
                     /evidence=ECO:0000269|PubMed:24187137,
                     ECO:0000269|PubMed:26359501; propagated from
                     UniProtKB/Swiss-Prot (Q9JLN9.2)"
     Site            2478
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9JLN9.2)"
     Site            2481
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9JLN9.2)"
     CDS             1..2549
                     /gene="Mtor"
                     /gene_synonym="2610315D21Rik; flat; FRAP; Frap1; FRAP2;
                     RAFT1; RAPT1"
                     /coded_by="NM_020009.2:121..7770"
                     /db_xref="CCDS:CCDS18937.1"
                     /db_xref="GeneID:56717"
                     /db_xref="MGI:MGI:1928394"
ORIGIN      
        1 mlgtgpavat asaatssnvs vlqqfasglk srneetraka akelqhyvtm elremsqees
       61 trfydqlnhh ifelvsssda nerkggilai asligveggn strigrfany lrnllpssdp
      121 vvmemaskai grlamagdtf taeyvefevk ralewlgadr negrrhaavl vlrelaisvp
      181 tfffqqvqpf fdnifvavwd pkqairegav aalraclilt tqrepkemqk pqwyrhtfee
      241 aekgfdetla kekgmnrddr ihgallilne lvrissmege rlreemeeit qqqlvhdkyc
      301 kdlmgfgtkp rhitpftsfq avqpqqpnal vgllgysspq glmgfgtsps pakstlvesr
      361 ccrdlmeekf dqvcqwvlkc rssknsliqm tilnllprla afrpsaftdt qylqdtmnhv
      421 lscvkkeker taafqalgll svavrsefkv ylprvldiir aalppkdfah krqktvqvda
      481 tvftcismla ramgpgiqqd ikellepmla vglspaltav lydlsrqipq lkkdiqdgll
      541 kmlslvlmhk plrhpgmpkg lahqlaspgl ttlpeasdva sitlalrtlg sfefeghslt
      601 qfvrhcadhf lnsehkeirm eaartcsrll tpsihlisgh ahvvsqtavq vvadvlskll
      661 vvgitdpdpd irycvlasld erfdahlaqa enlqalfval ndqvfeirel aictvgrlss
      721 mnpafvmpfl rkmliqilte lehsgigrik eqsarmlghl vsnaprlirp ymepilkali
      781 lklkdpdpdp npgvinnvla tigelaqvsg lemrkwvdel fiiimdmlqd ssllakrqva
      841 lwtlgqlvas tgyvvepyrk yptllevlln flkteqnqgt rreairvlgl lgaldpykhk
      901 vnigmidqsr dasavslses kssqdssdys tsemlvnmgn lpldefypav smvalmrifr
      961 dqslshhhtm vvqaitfifk slglkcvqfl pqvmptflnv irvcdgaire flfqqlgmlv
     1021 sfvkshirpy mdeivtlmre fwvmntsiqs tiillieqiv valggefkly lpqliphmlr
     1081 vfmhdnsqgr ivsikllaai qlfganlddy lhlllppivk lfdapevplp srkaaletvd
     1141 rltesldftd yasriihpiv rtldqspelr stamdtlssl vfqlgkkyqi fipmvnkvlv
     1201 rhrinhqryd vlicrivkgy tladeeedpl iyqhrmlrss qgdalasgpv etgpmkklhv
     1261 stinlqkawg aarrvskddw lewlrrlsle llkdssspsl rscwalaqay npmardlfna
     1321 afvscwseln edqqdelirs ielaltsqdi aevtqtllnl aefmehsdkg plplrddngi
     1381 vllgeraakc rayakalhyk elefqkgptp aileslisin nklqqpeaas gvleyamkhf
     1441 geleiqatwy eklhewedal vaydkkmdtn kedpelmlgr mrclealgew gqlhqqccek
     1501 wtlvndetqa kmarmaaaaa wglgqwdsme eytcmiprdt hdgafyravl alhqdlfsla
     1561 qqcidkardl ldaeltamag esysraygam vschmlsele eviqyklvpe rreiirqiww
     1621 erlqgcqriv edwqkilmvr slvvsphedm rtwlkyaslc gksgrlalah ktlvlllgvd
     1681 psrqldhplp tahpqvtyay mknmwksark idafqhmqhf vqtmqqqaqh aiatedqqhk
     1741 qelhklmarc flklgewqln lqginestip kvlqyysaat ehdrswykaw hawavmnfea
     1801 vlhykhqnqa rdekkklrha sganitnatt aattaasaaa atstegsnse seaesnensp
     1861 tpsplqkkvt edlsktllly tvpavqgffr sislsrgnnl qdtlrvltlw fdyghwpdvn
     1921 ealvegvkai qidtwlqvip qliaridtpr plvgrlihql ltdigryhpq aliypltvas
     1981 kstttarhna ankilknmce hsntlvqqam mvseelirva ilwhemwheg leeasrlyfg
     2041 ernvkgmfev leplhammer gpqtlketsf nqaygrdlme aqewcrkymk sgnvkdltqa
     2101 wdlyyhvfrr iskqlpqlts lelqyvspkl lmcrdlelav pgtydpnqpi iriqsiapsl
     2161 qvitskqrpr kltlmgsngh efvfllkghe dlrqdervmq lfglvntlla ndptslrknl
     2221 siqryavipl stnsgligwv phcdtlhali rdyrekkkil lniehrimlr mapdydhltl
     2281 mqkvevfeha vnntagddla kllwlkspss evwfdrrtny trslavmsmv gyilglgdrh
     2341 psnlmldrls gkilhidfgd cfevamtrek fpekipfrlt rmltnamevt gldgnyrttc
     2401 htvmevlreh kdsvmavlea fvydpllnwr lmdtntkgnk rsrtrtdsys agqsveildg
     2461 velgepahkk agttvpesih sfigdglvkp ealnkkaiqi inrvrdkltg rdfshddtld
     2521 vptqvellik qatshenlcq cyigwcpfw
//
LOCUS       NP_001349240             486 aa            linear   ROD 09-OCT-2023
DEFINITION  CUGBP Elav-like family member 4 isoform 33 [Mus musculus].
ACCESSION   NP_001349240 XP_006525577
VERSION     NP_001349240.1
DBSOURCE    REFSEQ: accession NM_001362311.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 486)
  AUTHORS   Salamon I, Park Y, Miskic T, Kopic J, Matteson P, Page NF, Roque A,
            McAuliffe GW, Favate J, Garcia-Forn M, Shah P, Judas M, Millonig
            JH, Kostovic I, De Rubeis S, Hart RP, Krsnik Z and Rasin MR.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    GeneRIF: Celf4 controls mRNA translation underlying synaptic
            development in the prenatal mammalian neocortex.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 486)
  AUTHORS   Shen Y, Zhang C, Xiao K, Liu D and Xie G.
  TITLE     CELF4 regulates spine formation and depression-like behaviors of
            mice
  JOURNAL   Biochem Biophys Res Commun 605, 39-44 (2022)
   PUBMED   35306363
  REMARK    GeneRIF: CELF4 regulates spine formation and depression-like
            behaviors of mice.
REFERENCE   3  (residues 1 to 486)
  AUTHORS   Moreau MX, Saillour Y, Cwetsch AW, Pierani A and Causeret F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   4  (residues 1 to 486)
  AUTHORS   Li C, Li X, Bi Z, Sugino K, Wang G, Zhu T and Liu Z.
  TITLE     Comprehensive transcriptome analysis of cochlear spiral ganglion
            neurons at multiple ages
  JOURNAL   Elife 9, e50491 (2020)
   PUBMED   31913118
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 486)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 486)
  AUTHORS   Ladd AN, Taffet G, Hartley C, Kearney DL and Cooper TA.
  TITLE     Cardiac tissue-specific repression of CELF activity disrupts
            alternative splicing and causes cardiomyopathy
  JOURNAL   Mol Cell Biol 25 (14), 6267-6278 (2005)
   PUBMED   15988035
  REMARK    GeneRIF: CELF protein activity is required for normal alternative
            splicing in the heart in vivo and normal CELF-mediated alternative
            splicing regulation is in turn required for normal cardiac
            function.
REFERENCE   7  (residues 1 to 486)
  AUTHORS   Meins M, Schlickum S, Wilhelm C, Missbach J, Yadav S, Glaser B,
            Grzmil M, Burfeind P and Laccone F.
  TITLE     Identification and characterization of murine Brunol4, a new member
            of the elav/bruno family
  JOURNAL   Cytogenet Genome Res 97 (3-4), 254-260 (2002)
   PUBMED   12438720
  REMARK    GeneRIF: cloning and characterization
REFERENCE   8  (residues 1 to 486)
  AUTHORS   Ladd AN, Charlet N and Cooper TA.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   9  (residues 1 to 486)
  AUTHORS   Good PJ, Chen Q, Warner SJ and Herring DC.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
REFERENCE   10 (residues 1 to 486)
  AUTHORS   Yulug IG, Egan SE, See CG and Fisher EM.
  TITLE     Mapping GRB2, a signal transduction gene in the human and the mouse
  JOURNAL   Genomics 22 (2), 313-318 (1994)
   PUBMED   7806216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121094.8 and AC144938.3.
            
            On Apr 12, 2018 this sequence version replaced XP_006525577.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.161091.1,
                                           SRR1660813.219515.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 13.92 cM"
     Protein         1..486
                     /product="CUGBP Elav-like family member 4 isoform 33"
                     /note="CUG-BP- and ETR-3-like factor 4; bruno-like protein
                     4; RNA-binding protein BRUNOL-4; bruno-like 4, RNA binding
                     protein"
                     /calculated_mol_wt=51801
     Region          1..298
                     /region_name="Sufficient for RNA-binding and MSE-dependent
                     splicing activity. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          18..39
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          49..135
                     /region_name="RRM1_CELF3_4_5_6"
                     /note="RNA recognition motif 1 (RRM1) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12632"
                     /db_xref="CDD:410041"
     Site            order(55,57,59..60,63,82,84,86,95..97,99,129,131)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410041"
     Region          <56..378
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     Region          121..149
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          151..231
                     /region_name="RRM2_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12635"
                     /db_xref="CDD:410043"
     Site            order(153,155,157..158,161,180,182,184,192..194,196,226,
                     228)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410043"
     Region          239..258
                     /region_name="Necessary for TNNT2 exon 5 inclusion.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          417..475
                     /region_name="RRM_SF"
                     /note="RNA recognition motif (RRM) superfamily; cl17169"
                     /db_xref="CDD:450164"
     CDS             1..486
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /coded_by="NM_001362311.1:531..1991"
                     /note="isoform 33 is encoded by transcript variant 37"
                     /db_xref="GeneID:108013"
                     /db_xref="MGI:MGI:1932407"
ORIGIN      
        1 myikmatlan gqadnaslst nglgsspgsa ghmnglshsp gnpstipmkd hdaiklfigq
       61 iprnldekdl kplfeefgki yeltvlkdrf tgmhkgcafl tyceresalk aqsalheqkt
      121 lpgmnrpiqv kpadsesrgg ssclrqppsq drklfvgmln kqqseddvrr lfeafgniee
      181 ctilrgpdgn skgcafvkys shaeaqaain alhgsqtmpg assslvvkfa dtdkertmrr
      241 mqqmagqmgm fnpmaipfga ygayaqalmq qqaalmasva qggylnpmaa faaaqmqqma
      301 alnmnglaaa pmtptsggst ppgitapavp sipspigvng ftglppqang qpaaeavfan
      361 gihpypaqsp taadplqqay agvqqyagpa aypaaygqis qafpqpppmi pqqqregpeg
      421 cnlliyhlpq efgdaelmqm flpfgfvsfd npasaqtaiq amngfqigmk rlkvqlkrpk
      481 danrpy
//
LOCUS       NP_001157709             317 aa            linear   ROD 09-OCT-2023
DEFINITION  E3 ubiquitin-protein ligase NRDP1 [Mus musculus].
ACCESSION   NP_001157709
VERSION     NP_001157709.1
DBSOURCE    REFSEQ: accession NM_001164237.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 317)
  AUTHORS   Luo ZY, Jiang TX, Zhang T, Xu P and Qiu XB.
  TITLE     Ubiquitin Ligase Nrdp1 Controls Autophagy-Associated Acrosome
            Biogenesis and Mitochondrial Arrangement during Spermiogenesis
  JOURNAL   Cells 12 (18), 2211 (2023)
   PUBMED   37759433
  REMARK    GeneRIF: Ubiquitin Ligase Nrdp1 Controls Autophagy-Associated
            Acrosome Biogenesis and Mitochondrial Arrangement during
            Spermiogenesis.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 317)
  AUTHORS   Moreno-Lanceta A, Medrano-Bosch M, Fundora Y, Perramon M, Aspas J,
            Parra-Robert M, Baena S, Fondevila C, Edelman ER, Jimenez W and
            Melgar-Lesmes P.
  TITLE     RNF41 orchestrates macrophage-driven fibrosis resolution and
            hepatic regeneration
  JOURNAL   Sci Transl Med 15 (704), eabq6225 (2023)
   PUBMED   37437019
  REMARK    GeneRIF: RNF41 orchestrates macrophage-driven fibrosis resolution
            and hepatic regeneration.
REFERENCE   3  (residues 1 to 317)
  AUTHORS   Meng Z, Xu R, Xie L, Wu Y, He Q, Gao P, He X, Chen Q, Xie Q, Zhang
            J and Yang Q.
  TITLE     A20/Nrdp1 interaction alters the inflammatory signaling profile by
            mediating K48- and K63-linked polyubiquitination of effectors MyD88
            and TBK1
  JOURNAL   J Biol Chem 297 (1), 100811 (2021)
   PUBMED   34023381
  REMARK    GeneRIF: A20/Nrdp1 interaction alters the inflammatory signaling
            profile by mediating K48- and K63-linked polyubiquitination of
            effectors MyD88 and TBK1.
REFERENCE   4  (residues 1 to 317)
  AUTHORS   Tullett KM, Tan PS, Park HY, Schittenhelm RB, Michael N, Li R,
            Policheni AN, Gruber E, Huang C, Fulcher AJ, Danne JC, Czabotar PE,
            Wakim LM, Mintern JD, Ramm G, Radford KJ, Caminschi I, O'Keeffe M,
            Villadangos JA, Wright MD, Blewitt ME, Heath WR, Shortman K,
            Purcell AW, Nicola NA, Zhang JG and Lahoud MH.
  TITLE     RNF41 regulates the damage recognition receptor Clec9A and antigen
            cross-presentation in mouse dendritic cells
  JOURNAL   Elife 9, e63452 (2020)
   PUBMED   33264090
  REMARK    GeneRIF: RNF41 regulates the damage recognition receptor Clec9A and
            antigen cross-presentation in mouse dendritic cells.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 317)
  AUTHORS   Yang M, Chen T, Li X, Yu Z, Tang S, Wang C, Gu Y, Liu Y, Xu S, Li
            W, Zhang X, Wang J and Cao X.
  TITLE     K33-linked polyubiquitination of Zap70 by Nrdp1 controls CD8(+) T
            cell activation
  JOURNAL   Nat Immunol 16 (12), 1253-1262 (2015)
   PUBMED   26390156
  REMARK    GeneRIF: Data suggest that ring finger protein 41 Nrdp1 terminates
            T cell antigen receptors (TCRs) signaling by inactivating Zap70
            kinase.
            Erratum:[Nat Immunol. 2020 Mar;21(3):355. PMID: 32034311]
REFERENCE   6  (residues 1 to 317)
  AUTHORS   Wu X, Yen L, Irwin L, Sweeney C and Carraway KL 3rd.
  TITLE     Stabilization of the E3 ubiquitin ligase Nrdp1 by the
            deubiquitinating enzyme USP8
  JOURNAL   Mol Cell Biol 24 (17), 7748-7757 (2004)
   PUBMED   15314180
REFERENCE   7  (residues 1 to 317)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (residues 1 to 317)
  AUTHORS   Qiu XB and Goldberg AL.
  TITLE     Nrdp1/FLRF is a ubiquitin ligase promoting ubiquitination and
            degradation of the epidermal growth factor receptor family member,
            ErbB3
  JOURNAL   Proc Natl Acad Sci U S A 99 (23), 14843-14848 (2002)
   PUBMED   12411582
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):17220.]
REFERENCE   9  (residues 1 to 317)
  AUTHORS   Ogino Y, Suzuki K, Haraguchi R, Satoh Y, Dolle P and Yamada G.
  TITLE     External genitalia formation: role of fibroblast growth factor,
            retinoic acid signaling, and distal urethral epithelium
  JOURNAL   Ann N Y Acad Sci 948, 13-31 (2001)
   PUBMED   11795391
REFERENCE   10 (residues 1 to 317)
  AUTHORS   Abdullah JM, Li X, Nachtman RG and Jurecic R.
  TITLE     FLRF, a novel evolutionarily conserved RING finger gene, is
            differentially expressed in mouse fetal and adult hematopoietic
            stem cells and progenitors
  JOURNAL   Blood Cells Mol Dis 27 (1), 320-333 (2001)
   PUBMED   11358394
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK045760.1, AK028551.1 and BC049078.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript which encodes a functional protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660821.105364.1,
                                           SRR1660821.132955.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..317
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 76.55 cM"
     Protein         1..317
                     /product="E3 ubiquitin-protein ligase NRDP1"
                     /EC_number="2.3.2.27"
                     /note="RING-type E3 ubiquitin transferase NRDP1"
                     /calculated_mol_wt=35760
     Region          15..57
                     /region_name="mRING-HC-C3HC3D_Nrdp1"
                     /note="Modified RING finger, HC subclass (C3HC3D-type),
                     found in neuregulin receptor degradation protein-1 (Nrdp1)
                     and similar proteins; cd16634"
                     /db_xref="CDD:438296"
     Region          137..315
                     /region_name="USP8_interact"
                     /note="USP8 interacting; pfam08941"
                     /db_xref="CDD:430333"
     CDS             1..317
                     /gene="Rnf41"
                     /gene_synonym="2210404G21Rik; 4930511A05Rik;
                     4933415P08Rik; D10Ertd722e; FLRF; Nrdp1"
                     /coded_by="NM_001164237.1:417..1370"
                     /db_xref="CCDS:CCDS24277.1"
                     /db_xref="GeneID:67588"
                     /db_xref="MGI:MGI:1914838"
ORIGIN      
        1 mgydvtrfqg dvdedlicpi csgvleepvq aphcehafcn acitqwfsqq qtcpvdrsvv
       61 tvahlrpvpr imrnmlsklq iacdnavfgc savvrldnlm shlsdcehnp krpvtceqgc
      121 glempkdelp nhncikhlrs vvqqqqsria elektsaehk hqlaeqkrdi qllkaymrai
      181 rsvnpnlqnl eetieyneil ewvnslqpar vtrwggmist pdavlqavik rslvesgcpa
      241 sivneliena herswpqgla tletrqmnrr yyenyvakri pgkqavvvma cenqhmgddm
      301 vqepglvmif ahgveei
//
LOCUS       NP_035032                597 aa            linear   ROD 09-OCT-2023
DEFINITION  nuclear factor erythroid 2-related factor 2 isoform 1 [Mus
            musculus].
ACCESSION   NP_035032
VERSION     NP_035032.1
DBSOURCE    REFSEQ: accession NM_010902.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 597)
  AUTHORS   Li F, Huang H, Zhao P, Jiang J, Ding X, Lu D and Ji L.
  TITLE     Curculigoside mitigates dextran sulfate sodium-induced colitis by
            activation of KEAP1-NRF2 interaction to inhibit oxidative damage
            and autophagy of intestinal epithelium barrier
  JOURNAL   Int J Mol Med 52 (5) (2023)
   PUBMED   37772380
  REMARK    GeneRIF: Curculigoside mitigates dextran sulfate sodium-induced
            colitis by activation of KEAP1-NRF2 interaction to inhibit
            oxidative damage and autophagy of intestinal epithelium barrier.
REFERENCE   2  (residues 1 to 597)
  AUTHORS   Dong C, Li J, Tang Q, Wang Y, Zeng C, Du L and Sun Q.
  TITLE     Denervation aggravates renal ischemia reperfusion injury via
            BMAL1-mediated Nrf2/ARE pathway
  JOURNAL   Arch Biochem Biophys 746, 109736 (2023)
   PUBMED   37657745
  REMARK    GeneRIF: Denervation aggravates renal ischemia reperfusion injury
            via BMAL1-mediated Nrf2/ARE pathway.
REFERENCE   3  (residues 1 to 597)
  AUTHORS   Vaikunthanathan T, Landmann E, Correa DM, Romano M, Trevelin SC,
            Peng Q, Crespo E, Corrado M, Lozano JJ, Pearce EL, Perpinan E,
            Zoccarato A, Siew L, Edwards-Hicks J, Khan R, Luu NT, Thursz MR,
            Newsome PN, Martinez-Llordella M, Shah N, Lechler RI, Shah AM,
            Sanchez-Fueyo A, Lombardi G and Safinia N.
  TITLE     Dysregulated anti-oxidant signalling and compromised mitochondrial
            integrity negatively influence regulatory T cell function and
            viability in liver disease
  JOURNAL   EBioMedicine 95, 104778 (2023)
   PUBMED   37657135
REFERENCE   4  (residues 1 to 597)
  AUTHORS   You T, Zhao Y, Liu S and Xu H.
  TITLE     Lactiplantibacillus plantarum P101 Attenuated
            Cyclophosphamide-Induced Liver Injury in Mice by Regulating the
            Nrf2/ARE Signaling Pathway
  JOURNAL   Int J Mol Sci 24 (17), 13424 (2023)
   PUBMED   37686229
  REMARK    GeneRIF: Lactiplantibacillus plantarum P101 Attenuated
            Cyclophosphamide-Induced Liver Injury in Mice by Regulating the
            Nrf2/ARE Signaling Pathway.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 597)
  AUTHORS   Wakabayashi N, Yagishita Y, Joshi T and Kensler TW.
  TITLE     Forced Hepatic Expression of NRF2 or NQO1 Impedes Hepatocyte Lipid
            Accumulation in a Lipodystrophy Mouse Model
  JOURNAL   Int J Mol Sci 24 (17), 13345 (2023)
   PUBMED   37686150
  REMARK    GeneRIF: Forced Hepatic Expression of NRF2 or NQO1 Impedes
            Hepatocyte Lipid Accumulation in a Lipodystrophy Mouse Model.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 597)
  AUTHORS   Yehiely F, Bamborough P, Da Costa M, Perry BJ, Thinakaran G, Cohen
            FE, Carlson GA and Prusiner SB.
  TITLE     Identification of candidate proteins binding to prion protein
  JOURNAL   Neurobiol Dis 3 (4), 339-355 (1997)
   PUBMED   9173930
  REMARK    Erratum:[Neurobiol Dis 2002 Jun;10(1):67-8]
REFERENCE   7  (residues 1 to 597)
  AUTHORS   Chan K, Lu R, Chang JC and Kan YW.
  TITLE     NRF2, a member of the NFE2 family of transcription factors, is not
            essential for murine erythropoiesis, growth, and development
  JOURNAL   Proc Natl Acad Sci U S A 93 (24), 13943-13948 (1996)
   PUBMED   8943040
REFERENCE   8  (residues 1 to 597)
  AUTHORS   Oyake T, Itoh K, Motohashi H, Hayashi N, Hoshino H, Nishizawa M,
            Yamamoto M and Igarashi K.
  TITLE     Bach proteins belong to a novel family of BTB-basic leucine zipper
            transcription factors that interact with MafK and regulate
            transcription through the NF-E2 site
  JOURNAL   Mol Cell Biol 16 (11), 6083-6095 (1996)
   PUBMED   8887638
REFERENCE   9  (residues 1 to 597)
  AUTHORS   Shivdasani RA and Orkin SH.
  TITLE     Erythropoiesis and globin gene expression in mice lacking the
            transcription factor NF-E2
  JOURNAL   Proc Natl Acad Sci U S A 92 (19), 8690-8694 (1995)
   PUBMED   7567998
REFERENCE   10 (residues 1 to 597)
  AUTHORS   Chui DH, Tang W and Orkin SH.
  TITLE     cDNA cloning of murine Nrf 2 gene, coding for a p45 NF-E2 related
            transcription factor
  JOURNAL   Biochem Biophys Res Commun 209 (1), 40-46 (1995)
   PUBMED   7726861
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL772404.5.
            
            Summary: This gene encodes a transcription factor which is a member
            of a small family of basic leucine zipper (bZIP) proteins. The
            encoded transcription factor regulates genes which contain
            antioxidant response elements (ARE) in their promoters; many of
            these genes encode proteins involved in response to injury and
            inflammation which includes the production of free radicals.
            [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026943.1, AK142347.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..597
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 44.75 cM"
     Protein         1..597
                     /product="nuclear factor erythroid 2-related factor 2
                     isoform 1"
                     /note="nuclear factor erythroid 2-related factor 2;
                     NFE2-related factor 2; NF-E2-related factor 2"
                     /calculated_mol_wt=66770
     Region          29..31
                     /region_name="DLG motif.
                     /evidence=ECO:0000305|PubMed:15581590,
                     ECO:0000305|PubMed:16581765, ECO:0000305|PubMed:16790436"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60795.2)"
     Site            40
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKC.
                     /evidence=ECO:0000250|UniProtKB:O54968; propagated from
                     UniProtKB/Swiss-Prot (Q60795.2)"
     Region          79..82
                     /region_name="ETGE motif.
                     /evidence=ECO:0000305|PubMed:15282312,
                     ECO:0000305|PubMed:16581765, ECO:0000305|PubMed:16790436"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60795.2)"
     Site            207
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q16236; propagated from
                     UniProtKB/Swiss-Prot (Q60795.2)"
     Region          327..440
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60795.2)"
     Site            454
                     /site_type="glycosylation"
                     /note="N-linked (Glc) (glycation) lysine.
                     /evidence=ECO:0000250|UniProtKB:Q16236; propagated from
                     UniProtKB/Swiss-Prot (Q60795.2)"
     Site            464
                     /site_type="glycosylation"
                     /note="N-linked (Glc) (glycation) lysine.
                     /evidence=ECO:0000250|UniProtKB:Q16236; propagated from
                     UniProtKB/Swiss-Prot (Q60795.2)"
     Site            479
                     /site_type="glycosylation"
                     /note="N-linked (Glc) (glycation) lysine.
                     /evidence=ECO:0000250|UniProtKB:Q16236; propagated from
                     UniProtKB/Swiss-Prot (Q60795.2)"
     Region          486..553
                     /region_name="bZIP_NFE2-like"
                     /note="Basic leucine zipper (bZIP) domain of Nuclear
                     Factor, Erythroid-derived 2 (NFE2) and similar proteins: a
                     DNA-binding and dimerization domain; cd14720"
                     /db_xref="CDD:269868"
     Region          487..549
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:269868"
     Region          491..510
                     /region_name="Basic motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00978"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60795.2)"
     Site            491
                     /site_type="glycosylation"
                     /note="N-linked (Glc) (glycation) arginine.
                     /evidence=ECO:0000250|UniProtKB:Q16236; propagated from
                     UniProtKB/Swiss-Prot (Q60795.2)"
     Site            order(495..496,498..500,502..507,509..511)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:269868"
     Site            order(510,513..514,517..518,520..521,524..525,527..528,
                     531..532,534..535,538..539,541..542)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:269868"
     Region          514..521
                     /region_name="Leucine-zipper.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00978"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60795.2)"
     Site            561
                     /site_type="glycosylation"
                     /note="N-linked (Glc) (glycation) arginine.
                     /evidence=ECO:0000250|UniProtKB:Q16236; propagated from
                     UniProtKB/Swiss-Prot (Q60795.2)"
     Region          563..597
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60795.2)"
     Site            566
                     /site_type="glycosylation"
                     /note="N-linked (Glc) (glycation) lysine.
                     /evidence=ECO:0000250|UniProtKB:Q16236; propagated from
                     UniProtKB/Swiss-Prot (Q60795.2)"
     Region          583..588
                     /region_name="Mediates interaction with CHD6 and is
                     necessary to activate transcription.
                     /evidence=ECO:0000250|UniProtKB:O54968"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60795.2)"
     Site            588
                     /site_type="acetylation"
                     /note="N6-acetyllysine, by CREBBP.
                     /evidence=ECO:0000250|UniProtKB:Q16236; propagated from
                     UniProtKB/Swiss-Prot (Q60795.2)"
     Site            591
                     /site_type="acetylation"
                     /note="N6-acetyllysine, by CREBBP.
                     /evidence=ECO:0000250|UniProtKB:Q16236; propagated from
                     UniProtKB/Swiss-Prot (Q60795.2)"
     CDS             1..597
                     /gene="Nfe2l2"
                     /gene_synonym="Nrf2"
                     /coded_by="NM_010902.5:109..1902"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS16150.1"
                     /db_xref="GeneID:18024"
                     /db_xref="MGI:MGI:108420"
ORIGIN      
        1 mmdlelpppg lqsqqdmdli dilwrqdidl gvsrevfdfs qrqkdyelek qkklekerqe
       61 qlqkeqekaf faqfqldeet geflpiqpaq hiqtdtsgsa sysqvahipk qdalyfedcm
      121 qllaetfpfv ddheslaldi pshaessvft aphqaqslns sleaamtdls sieqdmeqvw
      181 qelfsipelq clntenkqla dttavpspea tltemdsnyh fyssisslek evgncgphfl
      241 hgfedsfssi lstddasqlt sldsnptlnt dfgdefysaf iaepsdggsm pssaaisqsl
      301 selldgtieg cdlslckafn pkhaegtmef ndsdsgisln tspsraspeh svessiygdp
      361 ppgfsdseme eldsapgsvk qngpkaqpah spgdtvqpls paqghsapmr esqcenttkk
      421 evpvspghqk apftkdkhss rleahltrde lrakalhipf pvekiinlpv ddfnemmske
      481 qfneaqlali rdirrrgknk vaaqncrkrk leniveleqd lghlkderek llrekgendr
      541 nlhllkrrls tlylevfsml rdedgkpysp seyslqqtrd gnvflvpksk kpdtkkn
//
LOCUS       NP_001152977             240 aa            linear   ROD 09-OCT-2023
DEFINITION  tumor necrosis factor ligand superfamily member 13 isoform 2 [Mus
            musculus].
ACCESSION   NP_001152977
VERSION     NP_001152977.1
DBSOURCE    REFSEQ: accession NM_001159505.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 240)
  AUTHORS   Doll JR, Moreno-Fernandez ME, Stankiewicz TE, Wayland JL, Wilburn
            A, Weinhaus B, Chougnet CA, Giordano D, Cappelletti M, Presicce P,
            Kallapur SG, Salomonis N, Tilburgs T and Divanovic S.
  TITLE     BAFF and APRIL counterregulate susceptibility to
            inflammation-induced preterm birth
  JOURNAL   Cell Rep 42 (4), 112352 (2023)
   PUBMED   37027297
  REMARK    GeneRIF: BAFF and APRIL counterregulate susceptibility to
            inflammation-induced preterm birth.
REFERENCE   2  (residues 1 to 240)
  AUTHORS   Sturm N, Roger-Margueritat M, Pierrel F, Lehours P, Genevay M and
            Huard B.
  TITLE     Spatial heterogeneity for APRIL production by eosinophils in the
            small intestine
  JOURNAL   J Leukoc Biol 113 (4), 376-382 (2023)
   PUBMED   36808499
  REMARK    GeneRIF: Spatial heterogeneity for APRIL production by eosinophils
            in the small intestine.
REFERENCE   3  (residues 1 to 240)
  AUTHORS   Tsiantoulas D, Eslami M, Obermayer G, Clement M, Smeets D, Mayer
            FJ, Kiss MG, Enders L, Weisser J, Goderle L, Lambert J, Frommlet F,
            Mueller A, Hendrikx T, Ozsvar-Kozma M, Porsch F, Willen L,
            Afonyushkin T, Murphy JE, Fogelstrand P, Donze O, Pasterkamp G,
            Hoke M, Kubicek S, Jorgensen HF, Danchin N, Simon T, Scharnagl H,
            Marz W, Boren J, Hess H, Mallat Z, Schneider P and Binder CJ.
  TITLE     APRIL limits atherosclerosis by binding to heparan sulfate
            proteoglycans
  JOURNAL   Nature 597 (7874), 92-96 (2021)
   PUBMED   34433968
REFERENCE   4  (residues 1 to 240)
  AUTHORS   Chan CC, Harley ITW, Pfluger PT, Trompette A, Stankiewicz TE, Allen
            JL, Moreno-Fernandez ME, Damen MSMA, Oates JR, Alarcon PC, Doll JR,
            Flick MJ, Flick LM, Sanchez-Gurmaches J, Mukherjee R, Karns R,
            Helmrath M, Inge TH, Weisberg SP, Pamp SJ, Relman DA, Seeley RJ,
            Tschop MH, Karp CL and Divanovic S.
  TITLE     A BAFF/APRIL axis regulates obesogenic diet-driven weight gain
  JOURNAL   Nat Commun 12 (1), 2911 (2021)
   PUBMED   34006859
  REMARK    GeneRIF: A BAFF/APRIL axis regulates obesogenic diet-driven weight
            gain.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 240)
  AUTHORS   Benet Z, Jing Z and Fooksman DR.
  TITLE     Plasma cell dynamics in the bone marrow niche
  JOURNAL   Cell Rep 34 (6), 108733 (2021)
   PUBMED   33567286
REFERENCE   6  (residues 1 to 240)
  AUTHORS   Varfolomeev E, Kischkel F, Martin F, Seshasayee D, Wang H, Lawrence
            D, Olsson C, Tom L, Erickson S, French D, Schow P, Grewal IS and
            Ashkenazi A.
  TITLE     APRIL-deficient mice have normal immune system development
  JOURNAL   Mol Cell Biol 24 (3), 997-1006 (2004)
   PUBMED   14729948
REFERENCE   7  (residues 1 to 240)
  AUTHORS   MacLennan I and Vinuesa C.
  TITLE     Dendritic cells, BAFF, and APRIL: innate players in adaptive
            antibody responses
  JOURNAL   Immunity 17 (3), 235-238 (2002)
   PUBMED   12354377
  REMARK    GeneRIF: Review. Dendritic cell-derived TNF-family ligand APRIL
            enhances plasmablast survival and differentiation to plasma cells.
            Review article
REFERENCE   8  (residues 1 to 240)
  AUTHORS   Stein JV, Lopez-Fraga M, Elustondo FA, Carvalho-Pinto CE, Rodriguez
            D, Gomez-Caro R, De Jong J, Martinez-A C, Medema JP and Hahne M.
  TITLE     APRIL modulates B and T cell immunity
  JOURNAL   J Clin Invest 109 (12), 1587-1598 (2002)
   PUBMED   12070306
REFERENCE   9  (residues 1 to 240)
  AUTHORS   Locksley RM, Killeen N and Lenardo MJ.
  TITLE     The TNF and TNF receptor superfamilies: integrating mammalian
            biology
  JOURNAL   Cell 104 (4), 487-501 (2001)
   PUBMED   11239407
  REMARK    Review article
REFERENCE   10 (residues 1 to 240)
  AUTHORS   Yu G, Boone T, Delaney J, Hawkins N, Kelley M, Ramakrishnan M,
            McCabe S, Qiu WR, Kornuc M, Xia XZ, Guo J, Stolina M, Boyle WJ,
            Sarosi I, Hsu H, Senaldi G and Theill LE.
  TITLE     APRIL and TALL-I and receptors BCMA and TACI: system for regulating
            humoral immunity
  JOURNAL   Nat Immunol 1 (3), 252-256 (2000)
   PUBMED   10973284
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK009514.1, AK134028.1 and AL603707.5.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the central coding region, compared to variant 1.
            The resulting isoform (2) lacks one internal aa, compared to
            isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK134028.1, AK170351.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..240
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.86 cM"
     Protein         1..240
                     /product="tumor necrosis factor ligand superfamily member
                     13 isoform 2"
                     /note="a proliferation-inducing ligand; tumor necrosis
                     factor ligand 7b"
                     /calculated_mol_wt=26687
     Site            95..96
                     /site_type="cleavage"
                     /note="Cleavage, by furin. /evidence=ECO:0000250;
                     propagated from UniProtKB/Swiss-Prot (Q9D777.1)"
     Region          108..238
                     /region_name="TNF"
                     /note="Tumor Necrosis Factor; TNF superfamily members
                     include the cytokines: TNF (TNF-alpha), LT
                     (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL),
                     Fas ligand, and osteoprotegerin (OPG) ligand. These
                     proteins generally have an intracellular N-terminal...;
                     cd00184"
                     /db_xref="CDD:238108"
     Site            order(110,154,156,202,207,234,238)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:238108"
     Site            115
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9D777.1)"
     Site            order(129..130,135,169,176,181)
                     /site_type="active"
                     /note="receptor binding sites [active]"
                     /db_xref="CDD:238108"
     CDS             1..240
                     /gene="Tnfsf13"
                     /gene_synonym="2310026N09Rik; April; Tall2; Tnlg7b; Trdl1"
                     /coded_by="NM_001159505.1:296..1018"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS48827.1"
                     /db_xref="GeneID:69583"
                     /db_xref="MGI:MGI:1916833"
ORIGIN      
        1 mpasspghmg gsvrepalsv alwlswgavl gavtcavall iqqtelqslr revsrlqrsg
       61 gpsqkqgerp wqslweqspd vleawkdgak srrrravltq khkkkhsvlh lvpvnitskd
      121 sdvtevmwqp vlrrgrglea qgdivrvwdt giyllysqvl fhdvtftmgq vvsregqgrr
      181 etlfrcirsm psdpdrayns cysagvfhlh qgdiitvkip ranaklslsp hgtflgfvkl
//
LOCUS       NP_001349238             493 aa            linear   ROD 09-OCT-2023
DEFINITION  CUGBP Elav-like family member 4 isoform 31 [Mus musculus].
ACCESSION   NP_001349238
VERSION     NP_001349238.1
DBSOURCE    REFSEQ: accession NM_001362309.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 493)
  AUTHORS   Salamon I, Park Y, Miskic T, Kopic J, Matteson P, Page NF, Roque A,
            McAuliffe GW, Favate J, Garcia-Forn M, Shah P, Judas M, Millonig
            JH, Kostovic I, De Rubeis S, Hart RP, Krsnik Z and Rasin MR.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    GeneRIF: Celf4 controls mRNA translation underlying synaptic
            development in the prenatal mammalian neocortex.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 493)
  AUTHORS   Shen Y, Zhang C, Xiao K, Liu D and Xie G.
  TITLE     CELF4 regulates spine formation and depression-like behaviors of
            mice
  JOURNAL   Biochem Biophys Res Commun 605, 39-44 (2022)
   PUBMED   35306363
  REMARK    GeneRIF: CELF4 regulates spine formation and depression-like
            behaviors of mice.
REFERENCE   3  (residues 1 to 493)
  AUTHORS   Moreau MX, Saillour Y, Cwetsch AW, Pierani A and Causeret F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   4  (residues 1 to 493)
  AUTHORS   Li C, Li X, Bi Z, Sugino K, Wang G, Zhu T and Liu Z.
  TITLE     Comprehensive transcriptome analysis of cochlear spiral ganglion
            neurons at multiple ages
  JOURNAL   Elife 9, e50491 (2020)
   PUBMED   31913118
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 493)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 493)
  AUTHORS   Ladd AN, Taffet G, Hartley C, Kearney DL and Cooper TA.
  TITLE     Cardiac tissue-specific repression of CELF activity disrupts
            alternative splicing and causes cardiomyopathy
  JOURNAL   Mol Cell Biol 25 (14), 6267-6278 (2005)
   PUBMED   15988035
  REMARK    GeneRIF: CELF protein activity is required for normal alternative
            splicing in the heart in vivo and normal CELF-mediated alternative
            splicing regulation is in turn required for normal cardiac
            function.
REFERENCE   7  (residues 1 to 493)
  AUTHORS   Meins M, Schlickum S, Wilhelm C, Missbach J, Yadav S, Glaser B,
            Grzmil M, Burfeind P and Laccone F.
  TITLE     Identification and characterization of murine Brunol4, a new member
            of the elav/bruno family
  JOURNAL   Cytogenet Genome Res 97 (3-4), 254-260 (2002)
   PUBMED   12438720
  REMARK    GeneRIF: cloning and characterization
REFERENCE   8  (residues 1 to 493)
  AUTHORS   Ladd AN, Charlet N and Cooper TA.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   9  (residues 1 to 493)
  AUTHORS   Good PJ, Chen Q, Warner SJ and Herring DC.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
REFERENCE   10 (residues 1 to 493)
  AUTHORS   Yulug IG, Egan SE, See CG and Fisher EM.
  TITLE     Mapping GRB2, a signal transduction gene in the human and the mouse
  JOURNAL   Genomics 22 (2), 313-318 (1994)
   PUBMED   7806216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121094.8 and AC144938.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660825.66861.1,
                                           SRR1660813.91201.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..493
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 13.92 cM"
     Protein         1..493
                     /product="CUGBP Elav-like family member 4 isoform 31"
                     /note="CUG-BP- and ETR-3-like factor 4; bruno-like protein
                     4; RNA-binding protein BRUNOL-4; bruno-like 4, RNA binding
                     protein"
                     /calculated_mol_wt=52658
     Region          49..135
                     /region_name="RRM1_CELF3_4_5_6"
                     /note="RNA recognition motif 1 (RRM1) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12632"
                     /db_xref="CDD:410041"
     Site            order(55,57,59..60,63,82,84,86,95..97,99,129,131)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410041"
     Region          140..220
                     /region_name="RRM2_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12635"
                     /db_xref="CDD:410043"
     Site            order(142,144,146..147,150,169,171,173,181..183,185,215,
                     217)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410043"
     Region          404..482
                     /region_name="RRM3_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12639"
                     /db_xref="CDD:241083"
     CDS             1..493
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /coded_by="NM_001362309.1:531..2012"
                     /note="isoform 31 is encoded by transcript variant 35"
                     /db_xref="GeneID:108013"
                     /db_xref="MGI:MGI:1932407"
ORIGIN      
        1 myikmatlan gqadnaslst nglgsspgsa ghmnglshsp gnpstipmkd hdaiklfigq
       61 iprnldekdl kplfeefgki yeltvlkdrf tgmhkgcafl tyceresalk aqsalheqkt
      121 lpgmnrpiqv kpadsesrgd rklfvgmlnk qqseddvrrl feafgnieec tilrgpdgns
      181 kgcafvkyss haeaqaaina lhgsqtmpga ssslvvkfad tdkertmrrm qqmagqmgmf
      241 npmaipfgay gayaqamqqq aalmasvaqg gylnpmaafa aaqmqqmaal nmnglaaapm
      301 tptsggstpp gitapavpsi pspigvngft glppqangqp aaeavfangi hpypaqspta
      361 adplqqayag vqqyagpayp aaygqisqaf pqpppmipqq qregpegcnl liyhlpqefg
      421 daelmqmflp fgnvisskvf vdratnqskc fgfvsfdnpa saqtaiqamn gfqigmkrlk
      481 vqlkrpkdan rpy
//
LOCUS       NP_001157701             531 aa            linear   ROD 09-OCT-2023
DEFINITION  nuclear respiratory factor 1 isoform d [Mus musculus].
ACCESSION   NP_001157701
VERSION     NP_001157701.1
DBSOURCE    REFSEQ: accession NM_001164229.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 531)
  AUTHORS   Cheng C, Tian Y, Yang R, Guo W, Xiao K, Zhang F, Tian J, Deng Z,
            Yang W, Yang H and Zhou Z.
  TITLE     miR-5581 Contributes to Osteoarthritis by Targeting NRF1 to Disturb
            the Proliferation and Functions of Chondrocytes
  JOURNAL   Am J Pathol 193 (9), 1234-1247 (2023)
   PUBMED   37611970
  REMARK    GeneRIF: miR-5581 Contributes to Osteoarthritis by Targeting NRF1
            to Disturb the Proliferation and Functions of Chondrocytes.
REFERENCE   2  (residues 1 to 531)
  AUTHORS   Meng Z, Liang B, Wu Y, Liu C, Wang H, Du Y, Gan L, Gao E, Lau WB,
            Christopher TA, Lopez BL, Koch WJ, Ma X, Zhao F, Wang Y and Zhao J.
  TITLE     Hypoadiponectinemia-induced upregulation of microRNA449b
            downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury
            in diabetic mice
  JOURNAL   J Mol Cell Cardiol 182, 1-14 (2023)
   PUBMED   37437402
  REMARK    GeneRIF: Hypoadiponectinemia-induced upregulation of microRNA449b
            downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury
            in diabetic mice.
REFERENCE   3  (residues 1 to 531)
  AUTHORS   Zhao T, Zhang J, Lei H, Meng Y, Cheng H, Zhao Y, Geng G, Mu C, Chen
            L, Liu Q, Luo Q, Zhang C, Long Y, Su J, Wang Y, Li Z, Sun J, Chen
            G, Li Y, Liao X, Shang Y, Hu G, Chen Q and Zhu Y.
  TITLE     NRF1-mediated mitochondrial biogenesis antagonizes innate antiviral
            immunity
  JOURNAL   EMBO J 42 (16), e113258 (2023)
   PUBMED   37409632
  REMARK    GeneRIF: NRF1-mediated mitochondrial biogenesis antagonizes innate
            antiviral immunity.
REFERENCE   4  (residues 1 to 531)
  AUTHORS   Akl MG, Baccetto R, Stebbings BM, Li L and Widenmaier SB.
  TITLE     Euglycemia is affected by stress defense factor hepatocyte NRF1,
            but not NRF2
  JOURNAL   Biochem Biophys Res Commun 668, 96-103 (2023)
   PUBMED   37245295
  REMARK    GeneRIF: Euglycemia is affected by stress defense factor hepatocyte
            NRF1, but not NRF2.
REFERENCE   5  (residues 1 to 531)
  AUTHORS   Akl MG, Li L, Baccetto R, Phanse S, Zhang Q, Trites MJ, McDonald S,
            Aoki H, Babu M and Widenmaier SB.
  TITLE     Complementary gene regulation by NRF1 and NRF2 protects against
            hepatic cholesterol overload
  JOURNAL   Cell Rep 42 (4), 112399 (2023)
   PUBMED   37060561
  REMARK    GeneRIF: Complementary gene regulation by NRF1 and NRF2 protects
            against hepatic cholesterol overload.
            Erratum:[Cell Rep. 2023 Jul 25;42(7):112872. PMID: 37454293]
REFERENCE   6  (residues 1 to 531)
  AUTHORS   Carmona MC, Iglesias R, Obregon MJ, Darlington GJ, Villarroya F and
            Giralt M.
  TITLE     Mitochondrial biogenesis and thyroid status maturation in brown fat
            require CCAAT/enhancer-binding protein alpha
  JOURNAL   J Biol Chem 277 (24), 21489-21498 (2002)
   PUBMED   11940593
REFERENCE   7  (residues 1 to 531)
  AUTHORS   Huo L and Scarpulla RC.
  TITLE     Mitochondrial DNA instability and peri-implantation lethality
            associated with targeted disruption of nuclear respiratory factor 1
            in mice
  JOURNAL   Mol Cell Biol 21 (2), 644-654 (2001)
   PUBMED   11134350
REFERENCE   8  (residues 1 to 531)
  AUTHORS   Schaefer L, Engman H and Miller JB.
  TITLE     Coding sequence, chromosomal localization, and expression pattern
            of Nrf1: the mouse homolog of Drosophila erect wing
  JOURNAL   Mamm Genome 11 (2), 104-110 (2000)
   PUBMED   10656923
REFERENCE   9  (residues 1 to 531)
  AUTHORS   Huo L and Scarpulla RC.
  TITLE     Multiple 5'-untranslated exons in the nuclear respiratory factor 1
            gene span 47 kb and contribute to transcript heterogeneity and
            translational efficiency
  JOURNAL   Gene 233 (1-2), 213-224 (1999)
   PUBMED   10375638
REFERENCE   10 (residues 1 to 531)
  AUTHORS   Virbasius CA, Virbasius JV and Scarpulla RC.
  TITLE     NRF-1, an activator involved in nuclear-mitochondrial interactions,
            utilizes a new DNA-binding domain conserved in a family of
            developmental regulators
  JOURNAL   Genes Dev 7 (12A), 2431-2445 (1993)
   PUBMED   8253388
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134897.4 and AC153632.2.
            
            Transcript Variant: This variant (4) contains an alternate exon in
            the 5' UTR, contains an alternate 5' coding exon, and contains an
            alternate exon in the 3' coding region which results in a
            frameshift and early stop codon, compared to variant 1. This
            results in a distinct and longer C-terminus in isoform d, compared
            to isoform a. Variants 4 and 15 both encode the same isoform (d).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK135673.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..531
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 12.47 cM"
     Protein         1..531
                     /product="nuclear respiratory factor 1 isoform d"
                     /note="NRF-1; alpha-pal; alpha palindromic-binding
                     protein"
                     /calculated_mol_wt=56962
     Region          87..295
                     /region_name="Nrf1_DNA-bind"
                     /note="NLS-binding and DNA-binding and dimerization
                     domains of Nrf1; pfam10491"
                     /db_xref="CDD:402218"
     CDS             1..531
                     /gene="Nrf1"
                     /gene_synonym="D6Ertd415e"
                     /coded_by="NM_001164229.2:651..2246"
                     /note="isoform d is encoded by transcript variant 4"
                     /db_xref="CCDS:CCDS51739.1"
                     /db_xref="GeneID:18181"
                     /db_xref="MGI:MGI:1332235"
ORIGIN      
        1 meehgvtqte hmatieahav aqqvqqvhva tytehsmlsa dedspssped tsyddsdiln
       61 staadevtah laaavlgikp rashilgpvg maaaaavatg kkrkrphvfe snpsirkrqq
      121 trllrklrat ldeyttrvgq qaivlcisps kpnpvfkvfg aaplenvvrk yksmiledle
      181 salaehapap qevnselppl tidgipvsvd kmtqaqlraf ipemlkystg rgkpgwgkes
      241 ckpiwwpedi pwanvrsdvr teeqkqrvsw tqalrtivkn cykqhgredl lyafedqqtq
      301 tqattthsia hlvpsqtvvq tfsnpdgtvs liqvgtgatv atladaselp ttvtvaqvny
      361 savadgeveq nwatlqggem tiqttqasea tqavaslaea avaasqemqq gatvtmalns
      421 eaaahavatl aeatlqgggq ivlsgetaaa vgaltgvqda nglgspvlpe imasktrgyr
      481 hscgrdlyrl fsffllyskn nerillapat sgspcfyvrn iitirvgils s
//
LOCUS       NP_659168                347 aa            linear   ROD 09-OCT-2023
DEFINITION  histone deacetylase 11 [Mus musculus].
ACCESSION   NP_659168
VERSION     NP_659168.1
DBSOURCE    REFSEQ: accession NM_144919.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 347)
  AUTHORS   Baek SY, Lee J, Kim T, Lee H, Choi HS, Park H, Koh M, Kim E, Jung
            ME, Iliopoulos D, Lee JY, Kim J and Lee S.
  TITLE     Development of a novel histone deacetylase inhibitor unveils the
            role of HDAC11 in alleviating depression by inhibition of
            microglial activation
  JOURNAL   Biomed Pharmacother 166, 115312 (2023)
   PUBMED   37567072
  REMARK    GeneRIF: Development of a novel histone deacetylase inhibitor
            unveils the role of HDAC11 in alleviating depression by inhibition
            of microglial activation.
REFERENCE   2  (residues 1 to 347)
  AUTHORS   Wu H, Yin X, Zhao X, Wu Z, Xiao Y, Di Q, Sun P, Tang H, Quan J and
            Chen W.
  TITLE     HDAC11 negatively regulates antifungal immunity by inhibiting Nos2
            expression via binding with transcriptional repressor STAT3
  JOURNAL   Redox Biol 56, 102461 (2022)
   PUBMED   36087429
  REMARK    GeneRIF: HDAC11 negatively regulates antifungal immunity by
            inhibiting Nos2 expression via binding with transcriptional
            repressor STAT3.
REFERENCE   3  (residues 1 to 347)
  AUTHORS   Bagchi RA, Robinson EL, Hu T, Cao J, Hong JY, Tharp CA, Qasim H,
            Gavin KM, Pires da Silva J, Major JL, McConnell BK, Seto E, Lin H
            and McKinsey TA.
  TITLE     Reversible lysine fatty acylation of an anchoring protein mediates
            adipocyte adrenergic signaling
  JOURNAL   Proc Natl Acad Sci U S A 119 (7) (2022)
   PUBMED   35149557
REFERENCE   4  (residues 1 to 347)
  AUTHORS   Bedogni F and Hevner RF.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 347)
  AUTHORS   Chen J, Cheng F, Sahakian E, Powers J, Wang Z, Tao J, Seto E,
            Pinilla-Ibarz J and Sotomayor EM.
  TITLE     HDAC11 regulates expression of C/EBPbeta and immunosuppressive
            molecules in myeloid-derived suppressor cells
  JOURNAL   J Leukoc Biol 109 (5), 891-900 (2021)
   PUBMED   33866588
  REMARK    GeneRIF: HDAC11 regulates expression of C/EBPbeta and
            immunosuppressive molecules in myeloid-derived suppressor cells.
REFERENCE   6  (residues 1 to 347)
  AUTHORS   Liu H, Hu Q, Kaufman A, D'Ercole AJ and Ye P.
  TITLE     Developmental expression of histone deacetylase 11 in the murine
            brain
  JOURNAL   J Neurosci Res 86 (3), 537-543 (2008)
   PUBMED   17893925
  REMARK    GeneRIF: Role for HDAC11 in central nervous system histone
            deacetylation and the development of oligodendrocytes and neurons
            during postnatal development.
REFERENCE   7  (residues 1 to 347)
  AUTHORS   Izzi L, Silvestri C, von Both I, Labbe E, Zakin L, Wrana JL and
            Attisano L.
  TITLE     Foxh1 recruits Gsc to negatively regulate Mixl1 expression during
            early mouse development
  JOURNAL   EMBO J 26 (13), 3132-3143 (2007)
   PUBMED   17568773
REFERENCE   8  (residues 1 to 347)
  AUTHORS   Kuninger D, Kuzmickas R, Peng B, Pintar JE and Rotwein P.
  TITLE     Gene discovery by microarray: identification of novel genes induced
            during growth factor-mediated muscle cell survival and
            differentiation
  JOURNAL   Genomics 84 (5), 876-889 (2004)
   PUBMED   15475267
REFERENCE   9  (residues 1 to 347)
  AUTHORS   Pang AL, Taylor HC, Johnson W, Alexander S, Chen Y, Su YA, Li X,
            Ravindranath N, Dym M, Rennert OM and Chan WY.
  TITLE     Identification of differentially expressed genes in mouse
            spermatogenesis
  JOURNAL   J Androl 24 (6), 899-911 (2003)
   PUBMED   14581517
REFERENCE   10 (residues 1 to 347)
  AUTHORS   Verdin E, Dequiedt F and Kasler HG.
  TITLE     Class II histone deacetylases: versatile regulators
  JOURNAL   Trends Genet 19 (5), 286-293 (2003)
   PUBMED   12711221
  REMARK    Review article
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC110256.12
            and AC131764.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016208.1, AK045994.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..347
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 40.38 cM"
     Protein         1..347
                     /product="histone deacetylase 11"
                     /EC_number="3.5.1.98"
                     /note="HD11"
                     /calculated_mol_wt=39026
     Region          14..318
                     /region_name="Histone deacetylase"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91WA3.1)"
     Region          35..319
                     /region_name="HDAC_classIV"
                     /note="Histone deacetylase class IV also known as histone
                     deacetylase 11; cd09993"
                     /db_xref="CDD:212519"
     Site            order(41,140..143,151..153,181,183,257,261,301..302,304)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:212519"
     CDS             1..347
                     /gene="Hdac11"
                     /coded_by="NM_144919.2:32..1075"
                     /db_xref="CCDS:CCDS20366.1"
                     /db_xref="GeneID:232232"
                     /db_xref="MGI:MGI:2385252"
ORIGIN      
        1 mphatqlyqh vpekrwpivy sprynitfmg leklhpfdag kwgkvinflk eekllsdgml
       61 veareaseed llvvhtrryl nelkwsfvva titeippvif lpnflvqrkv lrplrtqtgg
      121 timagklave rgwainvggg fhhcssdrgg gfcayaditl aikflferve gisratiidl
      181 dahqgngher dfmgdkrvyi mdvynrhiyp gdrfakeair rkvelewgte deeylekver
      241 nvrrslqehl pdvvvynagt dvlegdrlgg lsispagivk rdevvfrvvr ahdipilmvt
      301 sggyqkrtar iiadsilnlh dlgligpefp cvsaqnsgip llscavp
//
LOCUS       NP_001351355             483 aa            linear   ROD 09-OCT-2023
DEFINITION  pro-neuregulin-1, membrane-bound isoform isoform 7 [Mus musculus].
ACCESSION   NP_001351355
VERSION     NP_001351355.1
DBSOURCE    REFSEQ: accession NM_001364426.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 483)
  AUTHORS   Mikami Y, Iwase F, Ohshima D, Tomida T and Adachi-Akahane S.
  TITLE     Compensatory role of neuregulin-1 in diabetic cardiomyopathy
  JOURNAL   J Pharmacol Sci 153 (3), 130-141 (2023)
   PUBMED   37770154
  REMARK    GeneRIF: Compensatory role of neuregulin-1 in diabetic
            cardiomyopathy.
REFERENCE   2  (residues 1 to 483)
  AUTHORS   Qiao XY, Wang Y, Zhang W, Li Q, Liu C, Dao JJ, Qiao CM, Cui C, Shen
            YQ and Zhao WJ.
  TITLE     Involvement of CXCL10 in Neuronal Damage under the Condition of
            Spinal Cord Injury and the Potential Therapeutic Effect of Nrg1
  JOURNAL   J Integr Neurosci 22 (4), 96 (2023)
   PUBMED   37519170
  REMARK    GeneRIF: Involvement of CXCL10 in Neuronal Damage under the
            Condition of Spinal Cord Injury and the Potential Therapeutic
            Effect of Nrg1.
REFERENCE   3  (residues 1 to 483)
  AUTHORS   Liu H, Lu P, He S, Luo Y, Fang Y, Benkaci S, Wu B, Wang Y and Zhou
            B.
  TITLE     beta-Catenin regulates endocardial cushion growth by suppressing
            p21
  JOURNAL   Life Sci Alliance 6 (9), e202302163 (2023)
   PUBMED   37385754
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 483)
  AUTHORS   Kong L, Hassinan CW, Gerstner F, Buettner JM, Petigrow JB, Valdivia
            DO, Chan-Cortes MH, Mistri A, Cao A, McGaugh SA, Denton M, Brown S,
            Ross J, Schwab MH, Simon CM and Sumner CJ.
  TITLE     Boosting neuregulin 1 type-III expression hastens SMA motor axon
            maturation
  JOURNAL   Acta Neuropathol Commun 11 (1), 53 (2023)
   PUBMED   36997967
  REMARK    GeneRIF: Boosting neuregulin 1 type-III expression hastens SMA
            motor axon maturation.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 483)
  AUTHORS   Zhang X, Xiao G, Johnson C, Cai Y, Horowitz ZK, Mennicke C, Coffey
            R, Haider M, Threadgill D, Eliscu R, Oldham MC, Greenbaum A and
            Ghashghaei HT.
  TITLE     Bulk and mosaic deletions of Egfr reveal regionally defined
            gliogenesis in the developing mouse forebrain
  JOURNAL   iScience 26 (3), 106242 (2023)
   PUBMED   36915679
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 483)
  AUTHORS   Gassmann M, Casagranda F, Orioli D, Simon H, Lai C, Klein R and
            Lemke G.
  TITLE     Aberrant neural and cardiac development in mice lacking the ErbB4
            neuregulin receptor
  JOURNAL   Nature 378 (6555), 390-394 (1995)
   PUBMED   7477376
REFERENCE   7  (residues 1 to 483)
  AUTHORS   Meyer,D. and Birchmeier,C.
  TITLE     Multiple essential functions of neuregulin in development
  JOURNAL   Nature 378 (6555), 386-390 (1995)
   PUBMED   7477375
  REMARK    Erratum:[Nature 1995 Dec 14;378(6558):753]
REFERENCE   8  (residues 1 to 483)
  AUTHORS   Moscoso LM, Chu GC, Gautam M, Noakes PG, Merlie JP and Sanes JR.
  TITLE     Synapse-associated expression of an acetylcholine receptor-inducing
            protein, ARIA/heregulin, and its putative receptors, ErbB2 and
            ErbB3, in developing mammalian muscle
  JOURNAL   Dev Biol 172 (1), 158-169 (1995)
   PUBMED   7589796
REFERENCE   9  (residues 1 to 483)
  AUTHORS   Yang Y, Spitzer E, Meyer D, Sachs M, Niemann C, Hartmann G, Weidner
            KM, Birchmeier C and Birchmeier W.
  TITLE     Sequential requirement of hepatocyte growth factor and neuregulin
            in the morphogenesis and differentiation of the mammary gland
  JOURNAL   J Cell Biol 131 (1), 215-226 (1995)
   PUBMED   7559778
REFERENCE   10 (residues 1 to 483)
  AUTHORS   Ho WH, Armanini MP, Nuijens A, Phillips HS and Osheroff PL.
  TITLE     Sensory and motor neuron-derived factor. A novel heregulin variant
            highly expressed in sensory and motor neurons
  JOURNAL   J Biol Chem 270 (24), 14523-14532 (1995)
   PUBMED   7782315
  REMARK    Erratum:[J Biol Chem. 1995 Nov 3;270(44):26722. PMID: 7592900]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132407.3 and AC127374.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK141037.1, SRR1660813.161391.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..483
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 18.75 cM"
     Protein         1..483
                     /product="pro-neuregulin-1, membrane-bound isoform isoform
                     7"
                     /note="heregulin; type III neuregulin 1; type I neuregulin
                     1; pro-neuregulin-1, membrane-bound isoform"
                     /calculated_mol_wt=52346
     Region          327..>483
                     /region_name="Neuregulin"
                     /note="Neuregulin family; pfam02158"
                     /db_xref="CDD:426627"
     CDS             1..483
                     /gene="Nrg1"
                     /gene_synonym="6030402G23Rik; ARIA; D230005F13Rik; GGF;
                     GGFII; Hgl; HRG; HRGalpha; NDF; Pro-NRG1; SMDF"
                     /coded_by="NM_001364426.1:641..2092"
                     /note="isoform 7 is encoded by transcript variant 7"
                     /db_xref="CCDS:CCDS90383.1"
                     /db_xref="GeneID:211323"
                     /db_xref="MGI:MGI:96083"
ORIGIN      
        1 meiyppdmse gaggrsssps tqlsadpsld glpaaehmpd thtedgrspg llglavpccv
       61 cleaerlrgc lnsekicivp ilaclvslcl ciaglkwvfv dkifeydspt hldpgglgqd
      121 pvisldptaa savlvsseay tspvskaqse aeahvtgqgd hvavasepsa vptrknrlsa
      181 fpplhstppp fpspartpev rtpksgtqpq ttetnlqtap klstststtg tshlikcaek
      241 ektfcvngge cfmvkdlsnp srylckcpne ftgdrcqnyv masfykhlgi efmeaeelyq
      301 krvltitgic iallvvgimc vvaycktkkq rqklhdrlrq slrsernnmv niangphhpn
      361 pppenvqlvn qyvsknviss ehiverevet sfstshytst ahhsttvtqt pshswsnght
      421 esiiseshsv immssvensr hsspaggprg rlhglggpre cnsflrhare tpdsyrdsph
      481 ser
//
LOCUS       NP_001397164             479 aa            linear   ROD 09-OCT-2023
DEFINITION  nuclear respiratory factor 1 isoform k [Mus musculus].
ACCESSION   NP_001397164
VERSION     NP_001397164.1
DBSOURCE    REFSEQ: accession NM_001410235.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 479)
  AUTHORS   Cheng C, Tian Y, Yang R, Guo W, Xiao K, Zhang F, Tian J, Deng Z,
            Yang W, Yang H and Zhou Z.
  TITLE     miR-5581 Contributes to Osteoarthritis by Targeting NRF1 to Disturb
            the Proliferation and Functions of Chondrocytes
  JOURNAL   Am J Pathol 193 (9), 1234-1247 (2023)
   PUBMED   37611970
  REMARK    GeneRIF: miR-5581 Contributes to Osteoarthritis by Targeting NRF1
            to Disturb the Proliferation and Functions of Chondrocytes.
REFERENCE   2  (residues 1 to 479)
  AUTHORS   Meng Z, Liang B, Wu Y, Liu C, Wang H, Du Y, Gan L, Gao E, Lau WB,
            Christopher TA, Lopez BL, Koch WJ, Ma X, Zhao F, Wang Y and Zhao J.
  TITLE     Hypoadiponectinemia-induced upregulation of microRNA449b
            downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury
            in diabetic mice
  JOURNAL   J Mol Cell Cardiol 182, 1-14 (2023)
   PUBMED   37437402
  REMARK    GeneRIF: Hypoadiponectinemia-induced upregulation of microRNA449b
            downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury
            in diabetic mice.
REFERENCE   3  (residues 1 to 479)
  AUTHORS   Zhao T, Zhang J, Lei H, Meng Y, Cheng H, Zhao Y, Geng G, Mu C, Chen
            L, Liu Q, Luo Q, Zhang C, Long Y, Su J, Wang Y, Li Z, Sun J, Chen
            G, Li Y, Liao X, Shang Y, Hu G, Chen Q and Zhu Y.
  TITLE     NRF1-mediated mitochondrial biogenesis antagonizes innate antiviral
            immunity
  JOURNAL   EMBO J 42 (16), e113258 (2023)
   PUBMED   37409632
  REMARK    GeneRIF: NRF1-mediated mitochondrial biogenesis antagonizes innate
            antiviral immunity.
REFERENCE   4  (residues 1 to 479)
  AUTHORS   Akl MG, Baccetto R, Stebbings BM, Li L and Widenmaier SB.
  TITLE     Euglycemia is affected by stress defense factor hepatocyte NRF1,
            but not NRF2
  JOURNAL   Biochem Biophys Res Commun 668, 96-103 (2023)
   PUBMED   37245295
  REMARK    GeneRIF: Euglycemia is affected by stress defense factor hepatocyte
            NRF1, but not NRF2.
REFERENCE   5  (residues 1 to 479)
  AUTHORS   Akl MG, Li L, Baccetto R, Phanse S, Zhang Q, Trites MJ, McDonald S,
            Aoki H, Babu M and Widenmaier SB.
  TITLE     Complementary gene regulation by NRF1 and NRF2 protects against
            hepatic cholesterol overload
  JOURNAL   Cell Rep 42 (4), 112399 (2023)
   PUBMED   37060561
  REMARK    GeneRIF: Complementary gene regulation by NRF1 and NRF2 protects
            against hepatic cholesterol overload.
            Erratum:[Cell Rep. 2023 Jul 25;42(7):112872. PMID: 37454293]
REFERENCE   6  (residues 1 to 479)
  AUTHORS   Carmona MC, Iglesias R, Obregon MJ, Darlington GJ, Villarroya F and
            Giralt M.
  TITLE     Mitochondrial biogenesis and thyroid status maturation in brown fat
            require CCAAT/enhancer-binding protein alpha
  JOURNAL   J Biol Chem 277 (24), 21489-21498 (2002)
   PUBMED   11940593
REFERENCE   7  (residues 1 to 479)
  AUTHORS   Huo L and Scarpulla RC.
  TITLE     Mitochondrial DNA instability and peri-implantation lethality
            associated with targeted disruption of nuclear respiratory factor 1
            in mice
  JOURNAL   Mol Cell Biol 21 (2), 644-654 (2001)
   PUBMED   11134350
REFERENCE   8  (residues 1 to 479)
  AUTHORS   Schaefer L, Engman H and Miller JB.
  TITLE     Coding sequence, chromosomal localization, and expression pattern
            of Nrf1: the mouse homolog of Drosophila erect wing
  JOURNAL   Mamm Genome 11 (2), 104-110 (2000)
   PUBMED   10656923
REFERENCE   9  (residues 1 to 479)
  AUTHORS   Huo L and Scarpulla RC.
  TITLE     Multiple 5'-untranslated exons in the nuclear respiratory factor 1
            gene span 47 kb and contribute to transcript heterogeneity and
            translational efficiency
  JOURNAL   Gene 233 (1-2), 213-224 (1999)
   PUBMED   10375638
REFERENCE   10 (residues 1 to 479)
  AUTHORS   Virbasius CA, Virbasius JV and Scarpulla RC.
  TITLE     NRF-1, an activator involved in nuclear-mitochondrial interactions,
            utilizes a new DNA-binding domain conserved in a family of
            developmental regulators
  JOURNAL   Genes Dev 7 (12A), 2431-2445 (1993)
   PUBMED   8253388
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134897.4 and AC153632.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422601.356247.1,
                                           ERR3363657.53708.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..479
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 12.47 cM"
     Protein         1..479
                     /product="nuclear respiratory factor 1 isoform k"
                     /note="NRF-1; alpha-pal; alpha palindromic-binding
                     protein"
                     /calculated_mol_wt=51067
     Region          87..283
                     /region_name="Nrf1_DNA-bind"
                     /note="NLS-binding and DNA-binding and dimerization
                     domains of Nrf1; pfam10491"
                     /db_xref="CDD:402218"
     CDS             1..479
                     /gene="Nrf1"
                     /gene_synonym="D6Ertd415e"
                     /coded_by="NM_001410235.1:274..1713"
                     /note="isoform k is encoded by transcript variant 25"
                     /db_xref="GeneID:18181"
                     /db_xref="MGI:MGI:1332235"
ORIGIN      
        1 meehgvtqte hmatieahav aqqvqqvhva tytehsmlsa dedspssped tsyddsdiln
       61 staadevtah laaagpvgma aaaavatgkk rkrphvfesn psirkrqqtr llrklratld
      121 eyttrvgqqa ivlcispskp npvfkvfgaa plenvvrkyk smiledlesa laehapapqe
      181 vnselpplti dgipvsvdkm tqaqlrafip emlkystgrg kpgwgkesck piwwpedipw
      241 anvrsdvrte eqkqrvswtq alrtivkncy kqhgredlly afedqqtqtq attthsiahl
      301 vpsqtvvqtf snpdgtvsli qvgtgatvat ladaselptt vtvaqvnysa vadgeveqnw
      361 atlqggemti qttqaseatq avaslaeaav aasqemqqga tvtmalnsea aahavatlae
      421 atlqgggqiv lsgetaaavg altgvqdang lfmadcggyk wilarrlqvg sslgregss
//
LOCUS       NP_057888                624 aa            linear   ROD 09-OCT-2023
DEFINITION  kelch-like ECH-associated protein 1 [Mus musculus].
ACCESSION   NP_057888
VERSION     NP_057888.1
DBSOURCE    REFSEQ: accession NM_016679.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 624)
  AUTHORS   Li F, Huang H, Zhao P, Jiang J, Ding X, Lu D and Ji L.
  TITLE     Curculigoside mitigates dextran sulfate sodium-induced colitis by
            activation of KEAP1-NRF2 interaction to inhibit oxidative damage
            and autophagy of intestinal epithelium barrier
  JOURNAL   Int J Mol Med 52 (5) (2023)
   PUBMED   37772380
  REMARK    GeneRIF: Curculigoside mitigates dextran sulfate sodium-induced
            colitis by activation of KEAP1-NRF2 interaction to inhibit
            oxidative damage and autophagy of intestinal epithelium barrier.
REFERENCE   2  (residues 1 to 624)
  AUTHORS   Baird L, Taguchi K, Zhang A, Takahashi Y, Suzuki T, Kensler TW and
            Yamamoto M.
  TITLE     A NRF2-induced secretory phenotype activates immune surveillance to
            remove irreparably damaged cells
  JOURNAL   Redox Biol 66, 102845 (2023)
   PUBMED   37597423
REFERENCE   3  (residues 1 to 624)
  AUTHORS   Zhang A, Suzuki T, Adachi S, Yoshida E, Sakaguchi S and Yamamoto M.
  TITLE     Nrf2 activation improves experimental rheumatoid arthritis
  JOURNAL   Free Radic Biol Med 207, 279-295 (2023)
   PUBMED   37494986
  REMARK    GeneRIF: Nrf2 activation improves experimental rheumatoid
            arthritis.
REFERENCE   4  (residues 1 to 624)
  AUTHORS   Ushimoto C, Sugiki S, Kunii K, Inoue S, Kuroda E, Akai R, Iwawaki T
            and Miyazawa K.
  TITLE     Dynamic change and preventive role of stress response via
            Keap1-Nrf2 during renal crystal formation
  JOURNAL   Free Radic Biol Med 207, 120-132 (2023)
   PUBMED   37451369
  REMARK    GeneRIF: Dynamic change and preventive role of stress response via
            Keap1-Nrf2 during renal crystal formation.
REFERENCE   5  (residues 1 to 624)
  AUTHORS   Zhou M, Barkema HW, Gao J, Yang J, Wang Y, Kastelic JP, Khan S, Liu
            G and Han B.
  TITLE     MicroRNA miR-223 modulates NLRP3 and Keap1, mitigating
            lipopolysaccharide-induced inflammation and oxidative stress in
            bovine mammary epithelial cells and murine mammary glands
  JOURNAL   Vet Res 54 (1), 78 (2023)
   PUBMED   37710276
  REMARK    GeneRIF: MicroRNA miR-223 modulates NLRP3 and Keap1, mitigating
            lipopolysaccharide-induced inflammation and oxidative stress in
            bovine mammary epithelial cells and murine mammary glands.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 624)
  AUTHORS   Zipper LM and Mulcahy RT.
  TITLE     The Keap1 BTB/POZ dimerization function is required to sequester
            Nrf2 in cytoplasm
  JOURNAL   J Biol Chem 277 (39), 36544-36552 (2002)
   PUBMED   12145307
REFERENCE   7  (residues 1 to 624)
  AUTHORS   Dinkova-Kostova AT, Holtzclaw WD, Cole RN, Itoh K, Wakabayashi N,
            Katoh Y, Yamamoto M and Talalay P.
  TITLE     Direct evidence that sulfhydryl groups of Keap1 are the sensors
            regulating induction of phase 2 enzymes that protect against
            carcinogens and oxidants
  JOURNAL   Proc Natl Acad Sci U S A 99 (18), 11908-11913 (2002)
   PUBMED   12193649
  REMARK    GeneRIF: evidence that sulfhydryl groups of Keap1 are the sensors
            regulating induction of phase 2 enzymes that protect against
            carcinogens and oxidants
REFERENCE   8  (residues 1 to 624)
  AUTHORS   Kotilinek LA, Bacskai B, Westerman M, Kawarabayashi T, Younkin L,
            Hyman BT, Younkin S and Ashe KH.
  TITLE     Reversible memory loss in a mouse transgenic model of Alzheimer's
            disease
  JOURNAL   J Neurosci 22 (15), 6331-6335 (2002)
   PUBMED   12151510
REFERENCE   9  (residues 1 to 624)
  AUTHORS   Itoh K, Wakabayashi N, Katoh Y, Ishii T, Igarashi K, Engel JD and
            Yamamoto M.
  TITLE     Keap1 represses nuclear activation of antioxidant responsive
            elements by Nrf2 through binding to the amino-terminal Neh2 domain
  JOURNAL   Genes Dev 13 (1), 76-86 (1999)
   PUBMED   9887101
REFERENCE   10 (residues 1 to 624)
  AUTHORS   Chu CC and Paul WE.
  TITLE     Expressed genes in interleukin-4 treated B cells identified by cDNA
            representational difference analysis
  JOURNAL   Mol Immunol 35 (8), 487-502 (1998)
   PUBMED   9798653
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163637.4, AK076234.1 and BY586021.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1, 2, 3, and 4 all encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.234071.1, AK076234.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..624
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 7.74 cM"
     Protein         1..624
                     /product="kelch-like ECH-associated protein 1"
                     /note="NRF2 cytosolic inhibitor; cytosolic inhibitor of
                     Nrf2; ring canal protein"
                     /calculated_mol_wt=69422
     Region          56..180
                     /region_name="BTB_POZ_KLHL19_KEAP1"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in Kelch-like
                     ECH-associated protein 1 (KEAP1); cd18248"
                     /db_xref="CDD:349557"
     Region          95..596
                     /region_name="PHA03098"
                     /note="kelch-like protein; Provisional"
                     /db_xref="CDD:222983"
     Site            order(106,109..110,115..117,125..126,157,161..162)
                     /site_type="other"
                     /note="cullin binding site [polypeptide binding]"
                     /db_xref="CDD:349557"
     Site            order(129,131..132,147..148,150..151,154)
                     /site_type="other"
                     /note="modulator binding site [chemical binding]"
                     /db_xref="CDD:349557"
     Site            151
                     /site_type="other"
                     /note="Sensor for electrophilic agents.
                     /evidence=ECO:0000269|PubMed:18268004,
                     ECO:0000269|PubMed:22014577, ECO:0000269|PubMed:26527616;
                     propagated from UniProtKB/Swiss-Prot (Q9Z2X8.1)"
     Site            257
                     /site_type="other"
                     /note="Sensor for electrophilic agents.
                     /evidence=ECO:0000250|UniProtKB:Q14145; propagated from
                     UniProtKB/Swiss-Prot (Q9Z2X8.1)"
     Site            273
                     /site_type="other"
                     /note="Sensor for electrophilic agents.
                     /evidence=ECO:0000269|PubMed:14764894,
                     ECO:0000269|PubMed:26527616; propagated from
                     UniProtKB/Swiss-Prot (Q9Z2X8.1)"
     Site            288
                     /site_type="other"
                     /note="Sensor for electrophilic agents.
                     /evidence=ECO:0000269|PubMed:14764894,
                     ECO:0000269|PubMed:22014577, ECO:0000269|PubMed:26527616;
                     propagated from UniProtKB/Swiss-Prot (Q9Z2X8.1)"
     Region          327..372
                     /region_name="Kelch 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2X8.1)"
     Region          362..409
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          373..423
                     /region_name="Kelch 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2X8.1)"
     Region          413..456
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          424..470
                     /region_name="Kelch 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2X8.1)"
     Site            434
                     /site_type="other"
                     /note="Sensor for electrophilic agents.
                     /evidence=ECO:0000269|PubMed:20498371; propagated from
                     UniProtKB/Swiss-Prot (Q9Z2X8.1)"
     Region          460..503
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          471..517
                     /region_name="Kelch 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2X8.1)"
     Region          507..551
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          519..564
                     /region_name="Kelch 5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2X8.1)"
     Region          554..597
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          565..611
                     /region_name="Kelch 6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2X8.1)"
     CDS             1..624
                     /gene="Keap1"
                     /gene_synonym="INRF2; mKIAA0132"
                     /coded_by="NM_016679.4:1624..3498"
                     /db_xref="CCDS:CCDS22897.1"
                     /db_xref="GeneID:50868"
                     /db_xref="MGI:MGI:1858732"
ORIGIN      
        1 mqpepklsga prssqflplw skcpegagda vmyastecka evtpsqdgnr tfsytledht
       61 kqafgvmnel rlsqqlcdvt lqvkyedipa aqfmahkvvl assspvfkam ftnglreqgm
      121 evvsiegihp kvmerliefa ytasisvgek cvlhvmngav myqidsvvra csdflvqqld
      181 psnaigianf aeqigctelh qrareyiymh fgevakqeef fnlshcqlat lisrddlnvr
      241 cesevfhaci dwvkydcpqr rfyvqallra vrchaltprf lqtqlqkcei lqadarckdy
      301 lvqifqeltl hkptqavpcr apkvgrliyt aggyfrqsls yleaynpsng swlrladlqv
      361 prsglagcvv ggllyavggr nnspdgntds saldcynpmt nqwspcasms vprnrigvgv
      421 idghiyavgg shgcihhssv eryeperdew hlvapmltrr igvgvavlnr llyavggfdg
      481 tnrlnsaecy ypernewrmi tpmntirsga gvcvlhnciy aaggydgqdq lnsverydve
      541 tetwtfvapm rhhrsalgit vhqgkiyvlg gydghtflds vecydpdsdt wsevtrmtsg
      601 rsgvgvavtm epcrkqidqq nctc
//
LOCUS       NP_001349209             535 aa            linear   ROD 09-OCT-2023
DEFINITION  CUGBP Elav-like family member 4 isoform 6 [Mus musculus].
ACCESSION   NP_001349209 XP_017173275
VERSION     NP_001349209.1
DBSOURCE    REFSEQ: accession NM_001362280.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 535)
  AUTHORS   Salamon I, Park Y, Miskic T, Kopic J, Matteson P, Page NF, Roque A,
            McAuliffe GW, Favate J, Garcia-Forn M, Shah P, Judas M, Millonig
            JH, Kostovic I, De Rubeis S, Hart RP, Krsnik Z and Rasin MR.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    GeneRIF: Celf4 controls mRNA translation underlying synaptic
            development in the prenatal mammalian neocortex.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 535)
  AUTHORS   Shen Y, Zhang C, Xiao K, Liu D and Xie G.
  TITLE     CELF4 regulates spine formation and depression-like behaviors of
            mice
  JOURNAL   Biochem Biophys Res Commun 605, 39-44 (2022)
   PUBMED   35306363
  REMARK    GeneRIF: CELF4 regulates spine formation and depression-like
            behaviors of mice.
REFERENCE   3  (residues 1 to 535)
  AUTHORS   Moreau MX, Saillour Y, Cwetsch AW, Pierani A and Causeret F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   4  (residues 1 to 535)
  AUTHORS   Li C, Li X, Bi Z, Sugino K, Wang G, Zhu T and Liu Z.
  TITLE     Comprehensive transcriptome analysis of cochlear spiral ganglion
            neurons at multiple ages
  JOURNAL   Elife 9, e50491 (2020)
   PUBMED   31913118
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 535)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 535)
  AUTHORS   Ladd AN, Taffet G, Hartley C, Kearney DL and Cooper TA.
  TITLE     Cardiac tissue-specific repression of CELF activity disrupts
            alternative splicing and causes cardiomyopathy
  JOURNAL   Mol Cell Biol 25 (14), 6267-6278 (2005)
   PUBMED   15988035
  REMARK    GeneRIF: CELF protein activity is required for normal alternative
            splicing in the heart in vivo and normal CELF-mediated alternative
            splicing regulation is in turn required for normal cardiac
            function.
REFERENCE   7  (residues 1 to 535)
  AUTHORS   Meins M, Schlickum S, Wilhelm C, Missbach J, Yadav S, Glaser B,
            Grzmil M, Burfeind P and Laccone F.
  TITLE     Identification and characterization of murine Brunol4, a new member
            of the elav/bruno family
  JOURNAL   Cytogenet Genome Res 97 (3-4), 254-260 (2002)
   PUBMED   12438720
  REMARK    GeneRIF: cloning and characterization
REFERENCE   8  (residues 1 to 535)
  AUTHORS   Ladd AN, Charlet N and Cooper TA.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   9  (residues 1 to 535)
  AUTHORS   Good PJ, Chen Q, Warner SJ and Herring DC.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
REFERENCE   10 (residues 1 to 535)
  AUTHORS   Yulug IG, Egan SE, See CG and Fisher EM.
  TITLE     Mapping GRB2, a signal transduction gene in the human and the mouse
  JOURNAL   Genomics 22 (2), 313-318 (1994)
   PUBMED   7806216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121094.8 and AC144938.3.
            
            On Apr 12, 2018 this sequence version replaced XP_017173275.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.210158.1,
                                           SRR7345562.3295548.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..535
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 13.92 cM"
     Protein         1..535
                     /product="CUGBP Elav-like family member 4 isoform 6"
                     /note="CUG-BP- and ETR-3-like factor 4; bruno-like protein
                     4; RNA-binding protein BRUNOL-4; bruno-like 4, RNA binding
                     protein"
                     /calculated_mol_wt=56935
     Region          1..298
                     /region_name="Sufficient for RNA-binding and MSE-dependent
                     splicing activity. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          18..39
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          49..135
                     /region_name="RRM1_CELF3_4_5_6"
                     /note="RNA recognition motif 1 (RRM1) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12632"
                     /db_xref="CDD:410041"
     Site            order(55,57,59..60,63,82,84,86,95..97,99,129,131)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410041"
     Region          <56..378
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     Region          121..149
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          151..231
                     /region_name="RRM2_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12635"
                     /db_xref="CDD:410043"
     Site            order(153,155,157..158,161,180,182,184,192..194,196,226,
                     228)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410043"
     Region          239..258
                     /region_name="Necessary for TNNT2 exon 5 inclusion.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          416..>444
                     /region_name="RRM_SF"
                     /note="RNA recognition motif (RRM) superfamily; cl17169"
                     /db_xref="CDD:450164"
     CDS             1..535
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /coded_by="NM_001362280.1:531..2138"
                     /note="isoform 6 is encoded by transcript variant 12"
                     /db_xref="GeneID:108013"
                     /db_xref="MGI:MGI:1932407"
ORIGIN      
        1 myikmatlan gqadnaslst nglgsspgsa ghmnglshsp gnpstipmkd hdaiklfigq
       61 iprnldekdl kplfeefgki yeltvlkdrf tgmhkgcafl tyceresalk aqsalheqkt
      121 lpgmnrpiqv kpadsesrgg ssclrqppsq drklfvgmln kqqseddvrr lfeafgniee
      181 ctilrgpdgn skgcafvkys shaeaqaain alhgsqtmpg assslvvkfa dtdkertmrr
      241 mqqmagqmgm fnpmaipfga ygayaqalmq qqaalmasva qggylnpmaa faaaqmqqma
      301 alnmnglaaa pmtptsggst ppgitapavp sipspigvng ftglppqang qpaaeavfan
      361 gihpypaqsp taadplqqay agvqqyagpa ypaaygqisq afpqpppmip qqqregpegc
      421 nlliyhlpqe fgdaelmqmf lpfgrhpvps rcqapscqgg qcaisssarr lrelrqpgqr
      481 tdrhpgherl pdrheeaqga aeaaqrrqsp vlsaggsvpr grpglaqgrm lnglh
//
LOCUS       NP_062681                714 aa            linear   ROD 09-OCT-2023
DEFINITION  cadherin-13 preproprotein [Mus musculus].
ACCESSION   NP_062681
VERSION     NP_062681.2
DBSOURCE    REFSEQ: accession NM_019707.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 714)
  AUTHORS   Popov VS, Brodsky IB, Balatskaya MN, Balatskiy AV, Ozhimalov ID,
            Kulebyakina MA, Semina EV, Arbatskiy MS, Isakova VS, Klimovich PS,
            Sysoeva VY, Kalinina NI, Tkachuk VA and Rubina KA.
  TITLE     T-Cadherin Deficiency Is Associated with Increased Blood Pressure
            after Physical Activity
  JOURNAL   Int J Mol Sci 24 (18), 14204 (2023)
   PUBMED   37762507
  REMARK    GeneRIF: T-Cadherin Deficiency Is Associated with Increased Blood
            Pressure after Physical Activity.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 714)
  AUTHORS   Fukuoka K, Mineo R, Kita S, Fukuda S, Okita T, Kawada-Horitani E,
            Iioka M, Fujii K, Kawada K, Fujishima Y, Nishizawa H, Maeda N and
            Shimomura I.
  TITLE     ER stress decreases exosome production through
            adiponectin/T-cadherin-dependent and -independent pathways
  JOURNAL   J Biol Chem 299 (9), 105114 (2023)
   PUBMED   37524131
  REMARK    GeneRIF: ER stress decreases exosome production through
            adiponectin/T-cadherin-dependent and -independent pathways.
REFERENCE   3  (residues 1 to 714)
  AUTHORS   Guo Q, Wang Y, Wang Q, Qian Y, Jiang Y, Dong X, Chen H, Chen X, Liu
            X, Yu S, Zhu J, Shan S, Wu B, Zhou W and Wang H.
  TITLE     In the developing cerebral cortex: axonogenesis, synapse formation,
            and synaptic plasticity are regulated by SATB2 target genes
  JOURNAL   Pediatr Res 93 (6), 1519-1527 (2023)
   PUBMED   36028553
REFERENCE   4  (residues 1 to 714)
  AUTHORS   Bedogni F and Hevner RF.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 714)
  AUTHORS   Polanco J, Reyes-Vigil F, Weisberg SD, Dhimitruka I and Bruses JL.
  TITLE     Differential Spatiotemporal Expression of Type I and Type II
            Cadherins Associated With the Segmentation of the Central Nervous
            System and Formation of Brain Nuclei in the Developing Mouse
  JOURNAL   Front Mol Neurosci 14, 633719 (2021)
   PUBMED   33833667
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 714)
  AUTHORS   Huang ZY, Wu Y, Hedrick N and Gutmann DH.
  TITLE     T-cadherin-mediated cell growth regulation involves G2 phase arrest
            and requires p21(CIP1/WAF1) expression
  JOURNAL   Mol Cell Biol 23 (2), 566-578 (2003)
   PUBMED   12509455
  REMARK    GeneRIF: T-cadherin has a role in growth regulation involving
            p21(CIP1/WAF1) expression and G2 arrest
REFERENCE   7  (residues 1 to 714)
  AUTHORS   Zhou S, Matsuyoshi N, Liang SB, Takeuchi T, Ohtsuki Y and Miyachi
            Y.
  TITLE     Expression of T-cadherin in Basal keratinocytes of skin
  JOURNAL   J Invest Dermatol 118 (6), 1080-1084 (2002)
   PUBMED   12060406
  REMARK    GeneRIF: Expression of T-cadherin in Basal keratinocytes of skin.
REFERENCE   8  (residues 1 to 714)
  AUTHORS   Takeuchi T, Misaki A, Liang SB, Tachibana A, Hayashi N, Sonobe H
            and Ohtsuki Y.
  TITLE     Expression of T-cadherin (CDH13, H-Cadherin) in human brain and its
            characteristics as a negative growth regulator of epidermal growth
            factor in neuroblastoma cells
  JOURNAL   J Neurochem 74 (4), 1489-1497 (2000)
   PUBMED   10737605
REFERENCE   9  (residues 1 to 714)
  AUTHORS   Kido M, Obata S, Tanihara H, Rochelle JM, Seldin MF, Taketani S and
            Suzuki ST.
  TITLE     Molecular properties and chromosomal location of cadherin-8
  JOURNAL   Genomics 48 (2), 186-194 (1998)
   PUBMED   9521872
REFERENCE   10 (residues 1 to 714)
  AUTHORS   Munro SB, Duclos AJ, Jackson AR, Baines MG and Blaschuk OW.
  TITLE     Characterization of cadherins expressed by murine thymocytes
  JOURNAL   Cell Immunol 169 (2), 309-312 (1996)
   PUBMED   8620560
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM944611.1, AK048724.1,
            CX242668.1, CF735928.1, AV343697.2, AI550332.1 and BB075948.1.
            
            On Jul 23, 2006 this sequence version replaced NP_062681.1.
            
            Summary: This gene encodes a member of the cadherin family of
            calcium-dependent glycoproteins that mediate cell adhesion and
            regulate many morphogenetic events during development. The encoded
            preproprotein is further processed to generate a mature protein.
            This gene is highly expressed in the vasculature including
            endothelial cells, smooth muscle cells and pericytes, where the
            encoded protein binds to adiponectin and has been implicated in the
            modulation of angiogenesis. Multiple distinct genes of the cadherin
            family, including this gene, are found on chromosome 8. [provided
            by RefSeq, Nov 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK134649.1, SRR1660811.189232.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..714
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 65.97 cM"
     Protein         1..714
                     /product="cadherin-13 preproprotein"
                     /EC_number="3.6.1.3"
                     /note="H-cadherin; heart cadherin; T-cadherin"
                     /calculated_mol_wt=75891
     sig_peptide     1..21
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=2313
     Region          26..111
                     /region_name="Cadherin_pro"
                     /note="Cadherin prodomain like; pfam08758"
                     /db_xref="CDD:430196"
     mat_peptide     139..693
                     /product="Cadherin-13. /id=PRO_0000003797"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WTR5.2)"
                     /calculated_mol_wt=60584
     Region          156..183
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WTR5.2)"
     Region          161..243
                     /region_name="CA"
                     /note="Cadherin repeats; smart00112"
                     /db_xref="CDD:214520"
     Region          249..359
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(256..257,318,320,355,357..358)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          368..469
                     /region_name="Cadherin"
                     /note="Cadherin domain; pfam00028"
                     /db_xref="CDD:394985"
     Site            382
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9WTR5.2)"
     Region          488..581
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(488..489,540,542,577,579..580)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Site            489
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9WTR5.2)"
     Site            500
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9WTR5.2)"
     Site            530
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9WTR5.2)"
     Region          589..680
                     /region_name="Cadherin"
                     /note="Cadherin domain; pfam00028"
                     /db_xref="CDD:394985"
     Site            598
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9WTR5.2)"
     Site            638
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9WTR5.2)"
     Site            671
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9WTR5.2)"
     CDS             1..714
                     /gene="Cdh13"
                     /gene_synonym="4932416G01Rik; Cdht; Tcad"
                     /coded_by="NM_019707.5:244..2388"
                     /db_xref="CCDS:CCDS52682.1"
                     /db_xref="GeneID:12554"
                     /db_xref="MGI:MGI:99551"
ORIGIN      
        1 mqprtpltlc vllsqvllvt saddlectpg fqrkvlhihq paefiedqpv lnltfndckg
       61 neklhyevss phfkvnsdgt lvalrnitav grtlfvhart phaedmaelv ivggkdiqgs
      121 lqdifkfart spvprqkrsi vvspilipen qrqpfprdvg kvvdsdrpeg skfrltgkgv
      181 dqdpkgtfri nentgsvsvt rtldretiat yqlyvettda sgktlegpvp levividqnd
      241 nrpifregpy ighvmegspt gttvmrmtaf daddpatdna llrynirqqt pdkpspnmfy
      301 idpekgdivt vvspalldre tlenpkyeli ieaqdmagld vgltgtatat ividdkndhs
      361 pkftkkefqa tveegavgvi vnltvedkdd pttgawraay tiingnpgqs feihtnpqtn
      421 egmlsvvkpl dyeisafhtl likvenedpl vpdvsygpss tatvhitvld vnegpvfypd
      481 pmmvtkqeni svgsvlltvn atdpdslqhq tirysiykdp agwlsinpin gtvdttavld
      541 respfvhnsv ytalflaids gnppatgtgt llitledind napviyptva evcddarnls
      601 vvilgasdkd lhpntdpfkf eihkqtvpdk vwkiskinnt halvsllqnl nkanynlpim
      661 vtdsgkppmt nitdlrvqvc scknskvdcn gagalhlsls llllfsllsl lsgl
//
LOCUS       NP_001349206             543 aa            linear   ROD 09-OCT-2023
DEFINITION  CUGBP Elav-like family member 4 isoform 3 [Mus musculus].
ACCESSION   NP_001349206
VERSION     NP_001349206.1
DBSOURCE    REFSEQ: accession NM_001362277.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 543)
  AUTHORS   Salamon I, Park Y, Miskic T, Kopic J, Matteson P, Page NF, Roque A,
            McAuliffe GW, Favate J, Garcia-Forn M, Shah P, Judas M, Millonig
            JH, Kostovic I, De Rubeis S, Hart RP, Krsnik Z and Rasin MR.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    GeneRIF: Celf4 controls mRNA translation underlying synaptic
            development in the prenatal mammalian neocortex.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 543)
  AUTHORS   Shen Y, Zhang C, Xiao K, Liu D and Xie G.
  TITLE     CELF4 regulates spine formation and depression-like behaviors of
            mice
  JOURNAL   Biochem Biophys Res Commun 605, 39-44 (2022)
   PUBMED   35306363
  REMARK    GeneRIF: CELF4 regulates spine formation and depression-like
            behaviors of mice.
REFERENCE   3  (residues 1 to 543)
  AUTHORS   Moreau MX, Saillour Y, Cwetsch AW, Pierani A and Causeret F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   4  (residues 1 to 543)
  AUTHORS   Li C, Li X, Bi Z, Sugino K, Wang G, Zhu T and Liu Z.
  TITLE     Comprehensive transcriptome analysis of cochlear spiral ganglion
            neurons at multiple ages
  JOURNAL   Elife 9, e50491 (2020)
   PUBMED   31913118
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 543)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 543)
  AUTHORS   Ladd AN, Taffet G, Hartley C, Kearney DL and Cooper TA.
  TITLE     Cardiac tissue-specific repression of CELF activity disrupts
            alternative splicing and causes cardiomyopathy
  JOURNAL   Mol Cell Biol 25 (14), 6267-6278 (2005)
   PUBMED   15988035
  REMARK    GeneRIF: CELF protein activity is required for normal alternative
            splicing in the heart in vivo and normal CELF-mediated alternative
            splicing regulation is in turn required for normal cardiac
            function.
REFERENCE   7  (residues 1 to 543)
  AUTHORS   Meins M, Schlickum S, Wilhelm C, Missbach J, Yadav S, Glaser B,
            Grzmil M, Burfeind P and Laccone F.
  TITLE     Identification and characterization of murine Brunol4, a new member
            of the elav/bruno family
  JOURNAL   Cytogenet Genome Res 97 (3-4), 254-260 (2002)
   PUBMED   12438720
  REMARK    GeneRIF: cloning and characterization
REFERENCE   8  (residues 1 to 543)
  AUTHORS   Ladd AN, Charlet N and Cooper TA.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   9  (residues 1 to 543)
  AUTHORS   Good PJ, Chen Q, Warner SJ and Herring DC.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
REFERENCE   10 (residues 1 to 543)
  AUTHORS   Yulug IG, Egan SE, See CG and Fisher EM.
  TITLE     Mapping GRB2, a signal transduction gene in the human and the mouse
  JOURNAL   Genomics 22 (2), 313-318 (1994)
   PUBMED   7806216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121094.8 and AC144938.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164131,
                              SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..543
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 13.92 cM"
     Protein         1..543
                     /product="CUGBP Elav-like family member 4 isoform 3"
                     /note="CUG-BP- and ETR-3-like factor 4; bruno-like protein
                     4; RNA-binding protein BRUNOL-4; bruno-like 4, RNA binding
                     protein"
                     /calculated_mol_wt=57720
     Region          18..39
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          49..135
                     /region_name="RRM1_CELF3_4_5_6"
                     /note="RNA recognition motif 1 (RRM1) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12632"
                     /db_xref="CDD:410041"
     Site            order(55,57,59..60,63,82,84,86,95..97,99,129,131)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410041"
     Region          121..149
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          150..230
                     /region_name="RRM2_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12635"
                     /db_xref="CDD:410043"
     Site            order(152,154,156..157,160,179,181,183,191..193,195,225,
                     227)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410043"
     Region          238..257
                     /region_name="Necessary for TNNT2 exon 5 inclusion.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          415..>443
                     /region_name="RRM_SF"
                     /note="RNA recognition motif (RRM) superfamily; cl17169"
                     /db_xref="CDD:450164"
     CDS             1..543
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /coded_by="NM_001362277.1:531..2162"
                     /note="isoform 3 is encoded by transcript variant 9"
                     /db_xref="GeneID:108013"
                     /db_xref="MGI:MGI:1932407"
ORIGIN      
        1 myikmatlan gqadnaslst nglgsspgsa ghmnglshsp gnpstipmkd hdaiklfigq
       61 iprnldekdl kplfeefgki yeltvlkdrf tgmhkgcafl tyceresalk aqsalheqkt
      121 lpgmnrpiqv kpadsesrgg ssclrqppsh rklfvgmlnk qqseddvrrl feafgnieec
      181 tilrgpdgns kgcafvkyss haeaqaaina lhgsqtmpga ssslvvkfad tdkertmrrm
      241 qqmagqmgmf npmaipfgay gayaqamqqq aalmasvaqg gylnpmaafa aaqmqqmaal
      301 nmnglaaapm tptsggstpp gitapavpsi pspigvngft glppqangqp aaeavfangi
      361 hpypaqspta adplqqayag vqqyagpaay paaygqisqa fpqpppmipq qqregpegcn
      421 lliyhlpqef gdaelmqmfl pfgrhpvpsr cqapscqggq caisssarrl relrqpgqrt
      481 drhpgherlp drheeaqgaa eaaqrrqspv lsaggsvprg rpglaqgqsn ppqsraelgi
      541 kft
//
LOCUS       NP_082716                 81 aa            linear   ROD 09-OCT-2023
DEFINITION  costars family protein ABRACL [Mus musculus].
ACCESSION   NP_082716 XP_001473295 XP_918042
VERSION     NP_082716.1
DBSOURCE    REFSEQ: accession NM_028440.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 81)
  AUTHORS   Troumpoukis D, Vasileiou AR, Siskos N, Stylianopoulou E, Ypsilantis
            P, Skavdis G and Grigoriou ME.
  TITLE     Characterization of the Abracl-Expressing Cell Populations in the
            Embryonic Mammalian Telencephalon
  JOURNAL   Biomolecules 13 (9), 1337 (2023)
   PUBMED   37759737
  REMARK    GeneRIF: Characterization of the Abracl-Expressing Cell Populations
            in the Embryonic Mammalian Telencephalon.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 81)
  AUTHORS   Pensold D, Symmank J, Hahn A, Lingner T, Salinas-Riester G, Downie
            BR, Ludewig F, Rotzsch A, Haag N, Andreas N, Schubert K, Hubner CA,
            Pieler T and Zimmer G.
  TITLE     The DNA Methyltransferase 1 (DNMT1) Controls the Shape and Dynamics
            of Migrating POA-Derived Interneurons Fated for the Murine Cerebral
            Cortex
  JOURNAL   Cereb Cortex 27 (12), 5696-5714 (2017)
   PUBMED   29117290
REFERENCE   3  (residues 1 to 81)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   4  (residues 1 to 81)
  AUTHORS   Nelson PS, Pritchard C, Abbott D and Clegg N.
  TITLE     The human (PEDB) and mouse (mPEDB) Prostate Expression Databases
  JOURNAL   Nucleic Acids Res 30 (1), 218-220 (2002)
   PUBMED   11752298
REFERENCE   5  (residues 1 to 81)
  AUTHORS   Kagami Y and Furuichi T.
  TITLE     Investigation of differentially expressed genes during the
            development of mouse cerebellum
  JOURNAL   Brain Res Gene Expr Patterns 1 (1), 39-59 (2001)
   PUBMED   15018818
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DV053786.1 and BC098509.1.
            
            On or before Jul 26, 2007 this sequence version replaced
            XP_918042.2, XP_001473295.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098509.1, DV046330.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849380,
                                           SAMN01164134 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..81
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 7.39 cM"
     Protein         1..81
                     /product="costars family protein ABRACL"
                     /note="ABRA C-terminal-like protein"
                     /calculated_mol_wt=8927
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:Q9P1F3; propagated from
                     UniProtKB/Swiss-Prot (Q4KML4.1)"
     Region          2..79
                     /region_name="Costars"
                     /note="pfam14705"
                     /db_xref="CDD:434145"
     CDS             1..81
                     /gene="Abracl"
                     /gene_synonym="1700028I04Rik; 3110003A17Rik"
                     /coded_by="NM_028440.1:193..438"
                     /db_xref="CCDS:CCDS48506.1"
                     /db_xref="GeneID:73112"
                     /db_xref="MGI:MGI:1920362"
ORIGIN      
        1 mnvehevnll veeihrlgsr nadgklsvkf gvlfqddrca nlfealvgtl kaakrrkivt
       61 yagelllqgv hddvdivllq d
//
LOCUS       NP_663412                221 aa            linear   ROD 09-OCT-2023
DEFINITION  CMRF35-like molecule 5 precursor [Mus musculus].
ACCESSION   NP_663412 XP_915016
VERSION     NP_663412.1
DBSOURCE    REFSEQ: accession NM_145437.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 221)
  AUTHORS   Wang C, Zheng X, Zhang J, Jiang X, Wang J, Li Y, Li X, Shen G, Peng
            J, Zheng P, Gu Y, Chen J, Lin M, Deng C, Gao H, Lu Z, Zhao Y and
            Luo M.
  TITLE     CD300ld on neutrophils is required for tumour-driven immune
            suppression
  JOURNAL   Nature 621 (7980), 830-839 (2023)
   PUBMED   37674079
  REMARK    GeneRIF: CD300ld on neutrophils is required for tumour-driven
            immune suppression.
REFERENCE   2  (residues 1 to 221)
  AUTHORS   Haga K, Fujimoto A, Takai-Todaka R, Miki M, Doan YH, Murakami K,
            Yokoyama M, Murata K, Nakanishi A and Katayama K.
  TITLE     Functional receptor molecules CD300lf and CD300ld within the CD300
            family enable murine noroviruses to infect cells
  JOURNAL   Proc Natl Acad Sci U S A 113 (41), E6248-E6255 (2016)
   PUBMED   27681626
  REMARK    GeneRIF: Our results indicate that direct interaction of MNV with
            two cell-surface molecules, CD300lf and CD300ld, dictates
            permissive noroviral infection.
REFERENCE   3  (residues 1 to 221)
  AUTHORS   Orchard RC, Wilen CB, Doench JG, Baldridge MT, McCune BT, Lee YC,
            Lee S, Pruett-Miller SM, Nelson CA, Fremont DH and Virgin HW.
  TITLE     Discovery of a proteinaceous cellular receptor for a norovirus
  JOURNAL   Science 353 (6302), 933-936 (2016)
   PUBMED   27540007
REFERENCE   4  (residues 1 to 221)
  AUTHORS   Enomoto Y, Yamanishi Y, Izawa K, Kaitani A, Takahashi M, Maehara A,
            Oki T, Takamatsu R, Kajikawa M, Takai T, Kitamura T and Kitaura J.
  TITLE     Characterization of leukocyte mono-immunoglobulin-like receptor 7
            (LMIR7)/CLM-3 as an activating receptor: its similarities to and
            differences from LMIR4/CLM-5
  JOURNAL   J Biol Chem 285 (46), 35274-35283 (2010)
   PUBMED   20817736
  REMARK    GeneRIF: Data show that LMIR7/CLM-3 shares similarities with
            LMIR4/CLM-5, although they are differentially regulated in their
            distribution, expression, and function.
REFERENCE   5  (residues 1 to 221)
  AUTHORS   Nakano T, Tahara-Hanaoka S, Nakahashi C, Can I, Totsuka N, Honda S,
            Shibuya K and Shibuya A.
  TITLE     Activation of neutrophils by a novel triggering immunoglobulin-like
            receptor MAIR-IV
  JOURNAL   Mol Immunol 45 (1), 289-294 (2008)
   PUBMED   17543387
  REMARK    GeneRIF: MAIR-IV may regulate activation of neutrophils and play an
            important role for innate immunity.
REFERENCE   6  (residues 1 to 221)
  AUTHORS   Izawa K, Kitaura J, Yamanishi Y, Matsuoka T, Oki T, Shibata F,
            Kumagai H, Nakajima H, Maeda-Yamamoto M, Hauchins JP, Tybulewicz
            VLJ, Takai T and Kitamura T.
  TITLE     Functional analysis of activating receptor LMIR4 as a counterpart
            of inhibitory receptor LMIR3
  JOURNAL   J Biol Chem 282 (25), 17997-18008 (2007)
   PUBMED   17438331
  REMARK    GeneRIF: the innate immune system is at least in part regulated by
            the qualitative and quantitative balance of the paired receptors
            LMIR3 and LMIR4
REFERENCE   7  (residues 1 to 221)
  AUTHORS   Chung DH, Humphrey MB, Nakamura MC, Ginzinger DG, Seaman WE and
            Daws MR.
  TITLE     CMRF-35-like molecule-1, a novel mouse myeloid receptor, can
            inhibit osteoclast formation
  JOURNAL   J Immunol 171 (12), 6541-6548 (2003)
   PUBMED   14662855
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL607025.21.
            
            On Dec 7, 2005 this sequence version replaced XP_915016.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC019814.1, AK028662.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..221
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 80.56 cM"
     Protein         1..221
                     /product="CMRF35-like molecule 5 precursor"
                     /note="CMRF35-like molecule 5; leukocyte mono-Ig-like
                     receptor 4; myeloid-associated immunoglobulin (Ig)-like
                     receptor IV; novel immunoglobulin V-set protein (Clm5);
                     MAIR-4; myeloid-associated immunoglobulin-like receptor 4;
                     CD300 antigen like family member D"
                     /calculated_mol_wt=22923
     sig_peptide     1..18
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=2049
     Region          23..124
                     /region_name="IgV_pIgR_like"
                     /note="Immunoglobulin (Ig)-like domain in the polymeric Ig
                     receptor (pIgR) and similar proteins; cd05716"
                     /db_xref="CDD:409381"
     Region          23..40
                     /region_name="FR1"
                     /note="FR1 [structural motif]"
                     /db_xref="CDD:409381"
     Region          27..32
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409381"
     Region          34..41
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409381"
     Region          38..48
                     /region_name="May play an important role in murine
                     norovirus (MNV) binding.
                     /evidence=ECO:0000269|PubMed:27681626"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCH2.1)"
     Region          41..49
                     /region_name="CDR1"
                     /note="CDR1 [structural motif]"
                     /db_xref="CDD:409381"
     Region          49..54
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409381"
     Site            49..51
                     /site_type="other"
                     /note="CDR1-dIgA binding residues [polypeptide binding]"
                     /db_xref="CDD:409381"
     Region          50..54
                     /region_name="FR2"
                     /note="FR2 [structural motif]"
                     /db_xref="CDD:409381"
     Region          55..76
                     /region_name="CDR2"
                     /note="CDR2 [structural motif]"
                     /db_xref="CDD:409381"
     Region          63..70
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409381"
     Region          74..76
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409381"
     Region          79..110
                     /region_name="FR3"
                     /note="FR3 [structural motif]"
                     /db_xref="CDD:409381"
     Region          79..85
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409381"
     Region          89..97
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409381"
     Region          103..110
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409381"
     Region          111..118
                     /region_name="CDR3"
                     /note="CDR3 [structural motif]"
                     /db_xref="CDD:409381"
     Region          118..124
                     /region_name="FR4"
                     /note="FR4 [structural motif]"
                     /db_xref="CDD:409381"
     Region          118..124
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409381"
     Region          165..170
                     /region_name="Important for maintaining surface expression
                     and for interaction with FCER1G"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCH2.1)"
     Region          177..186
                     /region_name="Important for maintaining surface expression
                     and for interaction with FCER1G"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCH2.1)"
     Site            178..198
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VCH2.1)"
     CDS             1..221
                     /gene="Cd300ld"
                     /gene_synonym="4732429D16Rik; Cd300ld1; clm-5; CLM5;
                     LMIR4; MAIR-IV"
                     /coded_by="NM_145437.2:77..742"
                     /db_xref="CCDS:CCDS25615.1"
                     /db_xref="GeneID:217305"
                     /db_xref="MGI:MGI:2442358"
ORIGIN      
        1 mwqfsalllf flpgcctaqd svtgpeevsg qeqgsltvqc ryssywkgyk kywcrgvpqr
       61 scdilvetdk seqlvkknrv sirdnqrdfi ftvtmedlrm sdagiywcgi tkggpdpmfk
      121 vnvnidqapk ssmmtttatv lksiqpsaen tgkeqvtqsk evtqsrphtr sllssiyfll
      181 mvfvelplll smlsavlwvt rpqrcfgrge ndlvkthspv a
//
LOCUS       NP_035790                105 aa            linear   ROD 09-OCT-2023
DEFINITION  thioredoxin [Mus musculus].
ACCESSION   NP_035790
VERSION     NP_035790.1
DBSOURCE    REFSEQ: accession NM_011660.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 105)
  AUTHORS   Wu A, Fang D, Liu Y, Shi X, Zhong Z, Zhou B, Ye L, Sun X and Jiang
            L.
  TITLE     Nuclear translocation of thioredoxin-1 promotes colorectal cancer
            development via modulation of the IL-6/STAT3 signaling axis through
            interaction with STAT3
  JOURNAL   Theranostics 13 (14), 4730-4744 (2023)
   PUBMED   37771783
  REMARK    GeneRIF: Nuclear translocation of thioredoxin-1 promotes colorectal
            cancer development via modulation of the IL-6/STAT3 signaling axis
            through interaction with STAT3.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 105)
  AUTHORS   Shao R, Lou X, Xue J, Yang Y, Ning D, Chen G and Jiang L.
  TITLE     Thioredoxin-1 regulates IRE1alpha to ameliorate sepsis-induced
            NLRP3 inflammasome activation and oxidative stress in Raw 264.7
            cell
  JOURNAL   Immunopharmacol Immunotoxicol 45 (3), 277-286 (2023)
   PUBMED   36263912
  REMARK    GeneRIF: Thioredoxin-1 regulates IRE1alpha to ameliorate
            sepsis-induced NLRP3 inflammasome activation and oxidative stress
            in Raw 264.7 cell.
REFERENCE   3  (residues 1 to 105)
  AUTHORS   Yu X, Teng Q, Bao K, Chudhary M, Qi H, Zhou W, Che H, Liu J, Ren X
            and Kong L.
  TITLE     Thioredoxin 1 overexpression attenuated diabetes-induced
            endoplasmic reticulum stress in Muller cells via apoptosis
            signal-regulating kinase 1
  JOURNAL   J Cell Biochem 124 (3), 421-433 (2023)
   PUBMED   36780445
  REMARK    GeneRIF: Thioredoxin 1 overexpression attenuated diabetes-induced
            endoplasmic reticulum stress in Muller cells via apoptosis
            signal-regulating kinase 1.
REFERENCE   4  (residues 1 to 105)
  AUTHORS   Nagarajan N, Oka SI, Nah J, Wu C, Zhai P, Mukai R, Xu X, Kashyap S,
            Huang CY, Sung EA, Mizushima W, Titus AS, Takayama K, Mourad Y,
            Francisco J, Liu T, Chen T, Li H and Sadoshima J.
  TITLE     Thioredoxin 1 promotes autophagy through transnitrosylation of Atg7
            during myocardial ischemia
  JOURNAL   J Clin Invest 133 (3), e162326 (2023)
   PUBMED   36480290
  REMARK    GeneRIF: Thioredoxin 1 promotes autophagy through
            transnitrosylation of Atg7 during myocardial ischemia.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 105)
  AUTHORS   Yang Q, Cai W, Jin H, Shen T and Yu J.
  TITLE     Downregulation of Inflammatory Response via Nrf2/Trx1/TXNIP Axis in
            Oxidative Stress-Induced ARPE-19 Cells and Mouse Model of AMD
  JOURNAL   Oxid Med Cell Longev 2022, 1497813 (2022)
   PUBMED   35993020
  REMARK    GeneRIF: Downregulation of Inflammatory Response via
            Nrf2/Trx1/TXNIP Axis in Oxidative Stress-Induced ARPE-19 Cells and
            Mouse Model of AMD.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 105)
  AUTHORS   Guthridge MA, Seldin M and Basilico C.
  TITLE     Induction of expression of growth-related genes by FGF-4 in mouse
            fibroblasts
  JOURNAL   Oncogene 12 (6), 1267-1278 (1996)
   PUBMED   8649829
REFERENCE   7  (residues 1 to 105)
  AUTHORS   Matsui M, Taniguchi Y, Hirota K, Taketo M and Yodoi J.
  TITLE     Structure of the mouse thioredoxin-encoding gene and its processed
            pseudogene
  JOURNAL   Gene 152 (2), 165-171 (1995)
   PUBMED   7835695
REFERENCE   8  (residues 1 to 105)
  AUTHORS   Tagaya,Y., Maeda,Y., Mitsui,A., Kondo,N., Matsui,H., Hamuro,J.,
            Brown,N., Arai,K., Yokota,T., Wakasugi,H. et al.
  TITLE     ATL-derived factor (ADF), an IL-2 receptor/Tac inducer homologous
            to thioredoxin; possible involvement of dithiol-reduction in the
            IL-2 receptor induction
  JOURNAL   EMBO J 13 (9), 2244 (1994)
   PUBMED   8187776
  REMARK    Correction to:[EMBO J. 1989 Mar;8(3):757-64. PMID: 2785919]
REFERENCE   9  (residues 1 to 105)
  AUTHORS   Taketo M, Matsui M, Rochelle JM, Yodoi J and Seldin MF.
  TITLE     Mouse thioredoxin gene maps on chromosome 4, whereas its pseudogene
            maps on chromosome 1
  JOURNAL   Genomics 21 (1), 251-253 (1994)
   PUBMED   8088797
REFERENCE   10 (residues 1 to 105)
  AUTHORS   Tagaya Y, Maeda Y, Mitsui A, Kondo N, Matsui H, Hamuro J, Brown N,
            Arai K, Yokota T, Wakasugi H et al.
  TITLE     ATL-derived factor (ADF), an IL-2 receptor/Tac inducer homologous
            to thioredoxin; possible involvement of dithiol-reduction in the
            IL-2 receptor induction
  JOURNAL   EMBO J 8 (3), 757-764 (1989)
   PUBMED   2785919
  REMARK    Erratum:[EMBO J. 1994 May 1;13(9):2244. PMID: 8187776]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL929406.10 and AK007537.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK007537.1, BY707596.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..105
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 31.87 cM"
     Protein         1..105
                     /product="thioredoxin"
                     /note="trx; ATL-derived factor"
                     /calculated_mol_wt=11544
     Region          2..103
                     /region_name="Thioredoxin"
                     /note="pfam00085"
                     /db_xref="CDD:395038"
     Site            3
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P10599; propagated from
                     UniProtKB/Swiss-Prot (P10639.3)"
     Site            26
                     /site_type="other"
                     /note="Deprotonates C-terminal active site Cys.
                     /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (P10639.3)"
     Site            order(32,35)
                     /site_type="active"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:239245"
     Site            33
                     /site_type="other"
                     /note="Contributes to redox potential value.
                     /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (P10639.3)"
     Site            34
                     /site_type="other"
                     /note="Contributes to redox potential value.
                     /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (P10639.3)"
     Site            39
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P10639.3)"
     Site            94
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P10639.3)"
     CDS             1..105
                     /gene="Txn1"
                     /gene_synonym="ADF; Trx1; Txn"
                     /coded_by="NM_011660.3:202..519"
                     /db_xref="CCDS:CCDS18207.1"
                     /db_xref="GeneID:22166"
                     /db_xref="MGI:MGI:98874"
ORIGIN      
        1 mvklieskea fqealaaagd klvvvdfsat wcgpckmikp ffhslcdkys nvvflevdvd
       61 dcqdvaadce vkcmptfqfy kkgqkvgefs gankekleas iteya
//
LOCUS       NP_001344264             750 aa            linear   ROD 09-OCT-2023
DEFINITION  neprilysin [Mus musculus].
ACCESSION   NP_001344264 XP_006501158
VERSION     NP_001344264.1
DBSOURCE    REFSEQ: accession NM_001357335.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 750)
  AUTHORS   Esser N, Mongovin SM, Mundinger TO, Barrow BM and Zraika S.
  TITLE     Neprilysin deficiency reduces hepatic gluconeogenesis in high
            fat-fed mice
  JOURNAL   Peptides 168, 171076 (2023)
   PUBMED   37572792
  REMARK    GeneRIF: Neprilysin deficiency reduces hepatic gluconeogenesis in
            high fat-fed mice.
REFERENCE   2  (residues 1 to 750)
  AUTHORS   Esser N, Mundinger TO, Barrow BM and Zraika S.
  TITLE     Acute Inhibition of Intestinal Neprilysin Enhances Insulin
            Secretion via GLP-1 Receptor Signaling in Male Mice
  JOURNAL   Endocrinology 164 (5) (2023)
   PUBMED   36964914
  REMARK    GeneRIF: Acute Inhibition of Intestinal Neprilysin Enhances Insulin
            Secretion via GLP-1 Receptor Signaling in Male Mice.
REFERENCE   3  (residues 1 to 750)
  AUTHORS   Ortiz C, Klein S, Reul WH, Magdaleno F, Groschl S, Dietrich P,
            Schierwagen R, Uschner FE, Torres S, Hieber C, Meier C, Kraus N,
            Tyc O, Brol M, Zeuzem S, Welsch C, Poglitsch M, Hellerbrand C,
            Alfonso-Prieto M, Mira F, Keller UAD, Tetzner A, Moore A, Walther T
            and Trebicka J.
  TITLE     Neprilysin-dependent neuropeptide Y cleavage in the liver promotes
            fibrosis by blocking NPY-receptor 1
  JOURNAL   Cell Rep 42 (2), 112059 (2023)
   PUBMED   36729833
  REMARK    GeneRIF: Neprilysin-dependent neuropeptide Y cleavage in the liver
            promotes fibrosis by blocking NPY-receptor 1.
REFERENCE   4  (residues 1 to 750)
  AUTHORS   Chen Y and Burnett JC Jr.
  TITLE     Biochemistry, Therapeutics, and Biomarker Implications of
            Neprilysin in Cardiorenal Disease
  JOURNAL   Clin Chem 63 (1), 108-115 (2017)
   PUBMED   28062615
  REMARK    Review article
REFERENCE   5  (residues 1 to 750)
  AUTHORS   Bayes-Genis A, Barallat J and Richards AM.
  TITLE     A Test in Context: Neprilysin: Function, Inhibition, and Biomarker
  JOURNAL   J Am Coll Cardiol 68 (6), 639-653 (2016)
   PUBMED   27491909
  REMARK    Review article
REFERENCE   6  (residues 1 to 750)
  AUTHORS   Turner AJ and Nalivaeva NN.
  TITLE     Proteinase dysbalance in pathology: the neprilysin (NEP) and
            angiotensin-converting enzyme (ACE) families
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 52 (4), 40-48 (2006)
   PUBMED   17543197
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   7  (residues 1 to 750)
  AUTHORS   Weil M, Itin A and Keshet E.
  TITLE     A role for mesenchyme-derived tachykinins in tooth and mammary
            gland morphogenesis
  JOURNAL   Development 121 (8), 2419-2428 (1995)
   PUBMED   7545574
REFERENCE   8  (residues 1 to 750)
  AUTHORS   Kalled SL, Siva N, Stein H and Reinherz EL.
  TITLE     The distribution of CD10 (NEP 24.11, CALLA) in humans and mice is
            similar in non-lymphoid organs but differs within the hematopoietic
            system: absence on murine T and B lymphoid progenitors
  JOURNAL   Eur J Immunol 25 (3), 677-687 (1995)
   PUBMED   7705396
REFERENCE   9  (residues 1 to 750)
  AUTHORS   Watson ML, Rao JK, Gilkeson GS, Ruiz P, Eicher EM, Pisetsky DS,
            Matsuzawa A, Rochelle JM and Seldin MF.
  TITLE     Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis
            gene to disease manifestations and renal disease-modifying loci
  JOURNAL   J Exp Med 176 (6), 1645-1656 (1992)
   PUBMED   1460423
REFERENCE   10 (residues 1 to 750)
  AUTHORS   Chen CY, Salles G, Seldin MF, Kister AE, Reinherz EL and Shipp MA.
  TITLE     Murine common acute lymphoblastic leukemia antigen (CD10 neutral
            endopeptidase 24.11). Molecular characterization, chromosomal
            localization, and modeling of the active site
  JOURNAL   J Immunol 148 (9), 2817-2825 (1992)
   PUBMED   1374101
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121993.2 and AC121840.3.
            
            On Oct 26, 2017 this sequence version replaced XP_006501158.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223971.3847.1,
                                           SRR10223969.3733.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..750
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 29.97 cM"
     Protein         1..750
                     /product="neprilysin"
                     /EC_number="3.4.24.11"
                     /note="common acute lymphoblastic leukemia antigen;
                     enkephalinase; atriopeptidase; neutral endopeptidase
                     24.11; skin fibroblast elastase"
                     /calculated_mol_wt=85571
     Site            4
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61391.3)"
     Site            6
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61391.3)"
     Region          16..23
                     /region_name="Stop-transfer sequence.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61391.3)"
     Site            29..51
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61391.3)"
     Region          77..748
                     /region_name="M13"
                     /note="Peptidase family M13 includes neprilysin and
                     endothelin-converting enzyme I; cd08662"
                     /db_xref="CDD:341056"
     Site            order(107,537,542..545,564,580..581,584..585,588,647,690,
                     693..694,711..712,718)
                     /site_type="active"
                     /db_xref="CDD:341056"
     Site            145
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19349973; propagated from
                     UniProtKB/Swiss-Prot (Q61391.3)"
     Site            211
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61391.3)"
     Site            285
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19349973; propagated from
                     UniProtKB/Swiss-Prot (Q61391.3)"
     Site            311
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19349973; propagated from
                     UniProtKB/Swiss-Prot (Q61391.3)"
     Site            325
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000250|UniProtKB:P08473; propagated from
                     UniProtKB/Swiss-Prot (Q61391.3)"
     Site            628
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000250|UniProtKB:P08473; propagated from
                     UniProtKB/Swiss-Prot (Q61391.3)"
     CDS             1..750
                     /gene="Mme"
                     /gene_synonym="6030454K05Rik; CALLA; CD10; NEP; SFE"
                     /coded_by="NM_001357335.1:416..2668"
                     /db_xref="CCDS:CCDS17381.1"
                     /db_xref="GeneID:17380"
                     /db_xref="MGI:MGI:97004"
ORIGIN      
        1 mgrsesqmdi tdinapkpkk kqrwtpleis lsvlvlllti iavtmialya tyddgickss
       61 dciksaarli qnmdasvepc tdffkyacgg wlkrnvipet ssrysnfdil rdelevilkd
      121 vlqepktedi vavqkaktly rscinesaid srggqpllkl lpdiygwpva sdnwdqtygt
      181 swtaeksiaq lnskygkkvl inffvgtddk nstqhiihfd qprlglpsrd yyectgiyke
      241 actayvdfmi svarlirqeq slpidenqls lemnkvmele keianattkp edrndpmlly
      301 nkmtlaklqn nfslevngks fswsnftnei mstvniniqn eeevvvyape yltklkpilt
      361 kysprdlqnl mswrfimdlv sslsrnykes rnafrkalyg ttsetatwrr canyvngnme
      421 navgrlyvea afageskhvv edliaqirev fiqtlddltw mdaetkkkae ekalaikeri
      481 gypddiisne nklnneylel nyredeyfen iiqnlkfsqs kqlkklrekv dkdewisgaa
      541 vvnafyssgr nqivfpagil qppffsaqqs nslnyggigm vigheithgf ddngrnfnkd
      601 gdlvdwwtqq sannfkdqsq cmvyqygnfs wdlaggqhln gintlgenia dnggigqayr
      661 ayqnyvkkng eekllpgldl nhkqlfflnf aqvwcgtyrp eyavnsiktd vhspgnfrii
      721 gtlqnsaefa dafhcrknsy mnperkcrvw
//
LOCUS       NP_032564                309 aa            linear   ROD 09-OCT-2023
DEFINITION  myristoylated alanine-rich C-kinase substrate [Mus musculus].
ACCESSION   NP_032564
VERSION     NP_032564.1
DBSOURCE    REFSEQ: accession NM_008538.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 309)
  AUTHORS   Yang Y, Yang H and Yang C.
  TITLE     Circ-AMOTL1 enhances cardiac fibrosis through binding with EIF4A3
            and stabilizing MARCKS expression in diabetic cardiomyopathy
  JOURNAL   Cell Signal 111, 110853 (2023)
   PUBMED   37586467
  REMARK    GeneRIF: Circ-AMOTL1 enhances cardiac fibrosis through binding with
            EIF4A3 and stabilizing MARCKS expression in diabetic
            cardiomyopathy.
REFERENCE   2  (residues 1 to 309)
  AUTHORS   Ji S, Yang Z, Gozali L, Kenney T, Kocabas A, Jinsook Park C and
            Hynes M.
  TITLE     Distinct expression of select and transcriptome-wide isolated
            3'UTRs suggests critical roles in development and transition states
  JOURNAL   PLoS One 16 (5), e0250669 (2021)
   PUBMED   33951080
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 309)
  AUTHORS   Yang P, Xu C, Reece EA, Chen X, Zhong J, Zhan M, Stumpo DJ,
            Blackshear PJ and Yang P.
  TITLE     Tip60- and sirtuin 2-regulated MARCKS acetylation and
            phosphorylation are required for diabetic embryopathy
  JOURNAL   Nat Commun 10 (1), 282 (2019)
   PUBMED   30655546
  REMARK    GeneRIF: Study in mice reports that Marcks is regulated by
            acetylation through Tip60 and Sirt2. Maternal diabetes-induced
            MARCKS acetylation is required for its phosphorylation, which
            disables the protective effects of MARCKS on mitochondria and the
            endoplasmic reticulum, leading to cellular organelle stress and
            neural tube defect formation.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 309)
  AUTHORS   Brudvig JJ, Cain JT, Sears RM, Schmidt-Grimminger GG, Wittchen ES,
            Adler KB, Ghashghaei HT and Weimer JM.
  TITLE     MARCKS regulates neuritogenesis and interacts with a CDC42
            signaling network
  JOURNAL   Sci Rep 8 (1), 13278 (2018)
   PUBMED   30185885
  REMARK    GeneRIF: While the presence of MARCKS does not affect whole brain
            levels of activated or total CDC42, authors propose that MARCKS is
            uniquely positioned to regulate CDC42 localization and interactions
            within specialized cellular compartments, such as nascent neurites.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 309)
  AUTHORS   Ziemba BP and Falke JJ.
  TITLE     A PKC-MARCKS-PI3K regulatory module links Ca2+ and PIP3 signals at
            the leading edge of polarized macrophages
  JOURNAL   PLoS One 13 (5), e0196678 (2018)
   PUBMED   29715315
  REMARK    GeneRIF: Strongly support the existence of a PKC-MARCKS-PI3K
            regulatory module.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 309)
  AUTHORS   Herget T, Brooks SF, Broad S and Rozengurt E.
  TITLE     Relationship between the major protein kinase C substrates acidic
            80-kDa protein-kinase-C substrate (80K) and myristoylated
            alanine-rich C-kinase substrate (MARCKS). Members of a gene family
            or equivalent genes in different species
  JOURNAL   Eur J Biochem 209 (1), 7-14 (1992)
   PUBMED   1396720
REFERENCE   7  (residues 1 to 309)
  AUTHORS   Li J and Aderem A.
  TITLE     MacMARCKS, a novel member of the MARCKS family of protein kinase C
            substrates
  JOURNAL   Cell 70 (5), 791-801 (1992)
   PUBMED   1516135
REFERENCE   8  (residues 1 to 309)
  AUTHORS   Blackshear PJ, Tuttle JS, Oakey RJ, Seldin MF, Chery M, Philippe C
            and Stumpo DJ.
  TITLE     Chromosomal mapping of the human (MACS) and mouse (Macs) genes
            encoding the MARCKS protein
  JOURNAL   Genomics 14 (1), 168-174 (1992)
   PUBMED   1427822
REFERENCE   9  (residues 1 to 309)
  AUTHORS   Blackshear PJ, Verghese GM, Johnson JD, Haupt DM and Stumpo DJ.
  TITLE     Characteristics of the F52 protein, a MARCKS homologue
  JOURNAL   J Biol Chem 267 (19), 13540-13546 (1992)
   PUBMED   1618855
REFERENCE   10 (residues 1 to 309)
  AUTHORS   Brooks SF, Herget T, Erusalimsky JD and Rozengurt E.
  TITLE     Protein kinase C activation potently down-regulates the expression
            of its major substrate, 80K, in Swiss 3T3 cells
  JOURNAL   EMBO J 10 (9), 2497-2505 (1991)
   PUBMED   1868832
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB569984.1, M60474.1, BC046601.1 and AC133944.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M60474.1, BC046601.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..309
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 19.49 cM"
     Protein         1..309
                     /product="myristoylated alanine-rich C-kinase substrate"
                     /note="80K protein"
                     /calculated_mol_wt=29530
     Region          1..309
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P26645.2)"
     Region          2..305
                     /region_name="MARCKS"
                     /note="MARCKS family; pfam02063"
                     /db_xref="CDD:366900"
     Site            15
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P26645.2)"
     Site            26
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P29966; propagated from
                     UniProtKB/Swiss-Prot (P26645.2)"
     Site            27
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P26645.2)"
     Site            29
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P29966; propagated from
                     UniProtKB/Swiss-Prot (P26645.2)"
     Site            46
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:15345747,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P26645.2)"
     Site            63
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P29966; propagated from
                     UniProtKB/Swiss-Prot (P26645.2)"
     Site            74
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P30009; propagated from
                     UniProtKB/Swiss-Prot (P26645.2)"
     Site            79
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P30009; propagated from
                     UniProtKB/Swiss-Prot (P26645.2)"
     Site            113
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by MAPK.
                     /evidence=ECO:0000269|PubMed:8849678; propagated from
                     UniProtKB/Swiss-Prot (P26645.2)"
     Site            122
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P30009; propagated from
                     UniProtKB/Swiss-Prot (P26645.2)"
     Site            128
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P12624; propagated from
                     UniProtKB/Swiss-Prot (P26645.2)"
     Site            138
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P26645.2)"
     Site            140
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P26645.2)"
     Site            141
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P26645.2)"
     Site            143
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P26645.2)"
     Region          145..169
                     /region_name="Calmodulin-binding (PSD)"
                     /note="propagated from UniProtKB/Swiss-Prot (P26645.2)"
     Site            152
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKC.
                     /evidence=ECO:0000269|PubMed:7588787; propagated from
                     UniProtKB/Swiss-Prot (P26645.2)"
     Site            156
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKC.
                     /evidence=ECO:0000269|PubMed:7588787; propagated from
                     UniProtKB/Swiss-Prot (P26645.2)"
     Site            160
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P12624; propagated from
                     UniProtKB/Swiss-Prot (P26645.2)"
     Site            163
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKC.
                     /evidence=ECO:0000269|PubMed:7588787,
                     ECO:0007744|PubMed:19131326; propagated from
                     UniProtKB/Swiss-Prot (P26645.2)"
     Site            171
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P26645.2)"
     Site            246
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:15345747; propagated from
                     UniProtKB/Swiss-Prot (P26645.2)"
     Site            291
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P29966; propagated from
                     UniProtKB/Swiss-Prot (P26645.2)"
     CDS             1..309
                     /gene="Marcks"
                     /gene_synonym="Macs; PKCSL"
                     /coded_by="NM_008538.2:392..1321"
                     /db_xref="CCDS:CCDS23784.1"
                     /db_xref="GeneID:17118"
                     /db_xref="MGI:MGI:96907"
ORIGIN      
        1 mgaqfsktaa kgeataerpg eaavasspsk angqenghvk vngdaspaaa epgakeelqa
       61 ngsapaadke epasgsaatp aaaekdeaaa atepgagaad keaaeaepae psspaaeaeg
      121 asasstsspk aedgaapsps setpkkkkkr fsfkksfkls gfsfkkskke sgegaeaega
      181 taegakdeaa aaaggegaaa pgeqaggaga egaaggepre aeaaepeqpe qpeqpaaeep
      241 qaeeqseaag ekaeepapga tagdassaag peqeapaatd eaaasaapaa spepqpecsp
      301 eappaptae
//
LOCUS       NP_001351358             311 aa            linear   ROD 09-OCT-2023
DEFINITION  pro-neuregulin-1, membrane-bound isoform isoform 10 precursor [Mus
            musculus].
ACCESSION   NP_001351358
VERSION     NP_001351358.1
DBSOURCE    REFSEQ: accession NM_001364429.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 311)
  AUTHORS   Mikami Y, Iwase F, Ohshima D, Tomida T and Adachi-Akahane S.
  TITLE     Compensatory role of neuregulin-1 in diabetic cardiomyopathy
  JOURNAL   J Pharmacol Sci 153 (3), 130-141 (2023)
   PUBMED   37770154
  REMARK    GeneRIF: Compensatory role of neuregulin-1 in diabetic
            cardiomyopathy.
REFERENCE   2  (residues 1 to 311)
  AUTHORS   Qiao XY, Wang Y, Zhang W, Li Q, Liu C, Dao JJ, Qiao CM, Cui C, Shen
            YQ and Zhao WJ.
  TITLE     Involvement of CXCL10 in Neuronal Damage under the Condition of
            Spinal Cord Injury and the Potential Therapeutic Effect of Nrg1
  JOURNAL   J Integr Neurosci 22 (4), 96 (2023)
   PUBMED   37519170
  REMARK    GeneRIF: Involvement of CXCL10 in Neuronal Damage under the
            Condition of Spinal Cord Injury and the Potential Therapeutic
            Effect of Nrg1.
REFERENCE   3  (residues 1 to 311)
  AUTHORS   Liu H, Lu P, He S, Luo Y, Fang Y, Benkaci S, Wu B, Wang Y and Zhou
            B.
  TITLE     beta-Catenin regulates endocardial cushion growth by suppressing
            p21
  JOURNAL   Life Sci Alliance 6 (9), e202302163 (2023)
   PUBMED   37385754
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 311)
  AUTHORS   Kong L, Hassinan CW, Gerstner F, Buettner JM, Petigrow JB, Valdivia
            DO, Chan-Cortes MH, Mistri A, Cao A, McGaugh SA, Denton M, Brown S,
            Ross J, Schwab MH, Simon CM and Sumner CJ.
  TITLE     Boosting neuregulin 1 type-III expression hastens SMA motor axon
            maturation
  JOURNAL   Acta Neuropathol Commun 11 (1), 53 (2023)
   PUBMED   36997967
  REMARK    GeneRIF: Boosting neuregulin 1 type-III expression hastens SMA
            motor axon maturation.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 311)
  AUTHORS   Zhang X, Xiao G, Johnson C, Cai Y, Horowitz ZK, Mennicke C, Coffey
            R, Haider M, Threadgill D, Eliscu R, Oldham MC, Greenbaum A and
            Ghashghaei HT.
  TITLE     Bulk and mosaic deletions of Egfr reveal regionally defined
            gliogenesis in the developing mouse forebrain
  JOURNAL   iScience 26 (3), 106242 (2023)
   PUBMED   36915679
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 311)
  AUTHORS   Gassmann M, Casagranda F, Orioli D, Simon H, Lai C, Klein R and
            Lemke G.
  TITLE     Aberrant neural and cardiac development in mice lacking the ErbB4
            neuregulin receptor
  JOURNAL   Nature 378 (6555), 390-394 (1995)
   PUBMED   7477376
REFERENCE   7  (residues 1 to 311)
  AUTHORS   Meyer,D. and Birchmeier,C.
  TITLE     Multiple essential functions of neuregulin in development
  JOURNAL   Nature 378 (6555), 386-390 (1995)
   PUBMED   7477375
  REMARK    Erratum:[Nature 1995 Dec 14;378(6558):753]
REFERENCE   8  (residues 1 to 311)
  AUTHORS   Moscoso LM, Chu GC, Gautam M, Noakes PG, Merlie JP and Sanes JR.
  TITLE     Synapse-associated expression of an acetylcholine receptor-inducing
            protein, ARIA/heregulin, and its putative receptors, ErbB2 and
            ErbB3, in developing mammalian muscle
  JOURNAL   Dev Biol 172 (1), 158-169 (1995)
   PUBMED   7589796
REFERENCE   9  (residues 1 to 311)
  AUTHORS   Yang Y, Spitzer E, Meyer D, Sachs M, Niemann C, Hartmann G, Weidner
            KM, Birchmeier C and Birchmeier W.
  TITLE     Sequential requirement of hepatocyte growth factor and neuregulin
            in the morphogenesis and differentiation of the mammary gland
  JOURNAL   J Cell Biol 131 (1), 215-226 (1995)
   PUBMED   7559778
REFERENCE   10 (residues 1 to 311)
  AUTHORS   Ho WH, Armanini MP, Nuijens A, Phillips HS and Osheroff PL.
  TITLE     Sensory and motor neuron-derived factor. A novel heregulin variant
            highly expressed in sensory and motor neurons
  JOURNAL   J Biol Chem 270 (24), 14523-14532 (1995)
   PUBMED   7782315
  REMARK    Erratum:[J Biol Chem. 1995 Nov 3;270(44):26722. PMID: 7592900]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132407.3 and AC127374.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK170314.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..311
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 18.75 cM"
     Protein         1..311
                     /product="pro-neuregulin-1, membrane-bound isoform isoform
                     10 precursor"
                     /note="heregulin; type III neuregulin 1; type I neuregulin
                     1; pro-neuregulin-1, membrane-bound isoform"
                     /calculated_mol_wt=31500
     sig_peptide     1..26
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=2841
     Region          <78..110
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          155..>311
                     /region_name="Neuregulin"
                     /note="Neuregulin family; pfam02158"
                     /db_xref="CDD:426627"
     CDS             1..311
                     /gene="Nrg1"
                     /gene_synonym="6030402G23Rik; ARIA; D230005F13Rik; GGF;
                     GGFII; Hgl; HRG; HRGalpha; NDF; Pro-NRG1; SMDF"
                     /coded_by="NM_001364429.1:39..974"
                     /note="isoform 10 precursor is encoded by transcript
                     variant 10"
                     /db_xref="GeneID:211323"
                     /db_xref="MGI:MGI:96083"
ORIGIN      
        1 mapapsllhy piivchllff adlttgmsas terpyvsses pirisvsteg antssststs
       61 ttgtshlikc aekektfcvn ggecfmvkdl snpsrylckc qpgftgarct envpmkvqtq
      121 ekaeelyqkr vltitgicia llvvgimcvv aycktkkqrq klhdrlrqsl rsernnmvni
      181 angphhpnpp penvqlvnqy vsknvisseh iverevetsf stshytstah hsttvtqtps
      241 hswsnghtes iiseshsvim mssvensrhs spaggprgrl hglggprecn sflrharetp
      301 dsyrdsphse r
//
LOCUS       NP_001349252             484 aa            linear   ROD 09-OCT-2023
DEFINITION  CUGBP Elav-like family member 4 isoform 40 [Mus musculus].
ACCESSION   NP_001349252
VERSION     NP_001349252.1
DBSOURCE    REFSEQ: accession NM_001362323.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 484)
  AUTHORS   Salamon I, Park Y, Miskic T, Kopic J, Matteson P, Page NF, Roque A,
            McAuliffe GW, Favate J, Garcia-Forn M, Shah P, Judas M, Millonig
            JH, Kostovic I, De Rubeis S, Hart RP, Krsnik Z and Rasin MR.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    GeneRIF: Celf4 controls mRNA translation underlying synaptic
            development in the prenatal mammalian neocortex.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 484)
  AUTHORS   Shen Y, Zhang C, Xiao K, Liu D and Xie G.
  TITLE     CELF4 regulates spine formation and depression-like behaviors of
            mice
  JOURNAL   Biochem Biophys Res Commun 605, 39-44 (2022)
   PUBMED   35306363
  REMARK    GeneRIF: CELF4 regulates spine formation and depression-like
            behaviors of mice.
REFERENCE   3  (residues 1 to 484)
  AUTHORS   Moreau MX, Saillour Y, Cwetsch AW, Pierani A and Causeret F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   4  (residues 1 to 484)
  AUTHORS   Li C, Li X, Bi Z, Sugino K, Wang G, Zhu T and Liu Z.
  TITLE     Comprehensive transcriptome analysis of cochlear spiral ganglion
            neurons at multiple ages
  JOURNAL   Elife 9, e50491 (2020)
   PUBMED   31913118
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 484)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 484)
  AUTHORS   Ladd AN, Taffet G, Hartley C, Kearney DL and Cooper TA.
  TITLE     Cardiac tissue-specific repression of CELF activity disrupts
            alternative splicing and causes cardiomyopathy
  JOURNAL   Mol Cell Biol 25 (14), 6267-6278 (2005)
   PUBMED   15988035
  REMARK    GeneRIF: CELF protein activity is required for normal alternative
            splicing in the heart in vivo and normal CELF-mediated alternative
            splicing regulation is in turn required for normal cardiac
            function.
REFERENCE   7  (residues 1 to 484)
  AUTHORS   Meins M, Schlickum S, Wilhelm C, Missbach J, Yadav S, Glaser B,
            Grzmil M, Burfeind P and Laccone F.
  TITLE     Identification and characterization of murine Brunol4, a new member
            of the elav/bruno family
  JOURNAL   Cytogenet Genome Res 97 (3-4), 254-260 (2002)
   PUBMED   12438720
  REMARK    GeneRIF: cloning and characterization
REFERENCE   8  (residues 1 to 484)
  AUTHORS   Ladd AN, Charlet N and Cooper TA.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   9  (residues 1 to 484)
  AUTHORS   Good PJ, Chen Q, Warner SJ and Herring DC.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
REFERENCE   10 (residues 1 to 484)
  AUTHORS   Yulug IG, Egan SE, See CG and Fisher EM.
  TITLE     Mapping GRB2, a signal transduction gene in the human and the mouse
  JOURNAL   Genomics 22 (2), 313-318 (1994)
   PUBMED   7806216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121094.8 and AC144938.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660819.107381.1,
                                           SRR1660815.272887.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..484
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 13.92 cM"
     Protein         1..484
                     /product="CUGBP Elav-like family member 4 isoform 40"
                     /note="CUG-BP- and ETR-3-like factor 4; bruno-like protein
                     4; RNA-binding protein BRUNOL-4; bruno-like 4, RNA binding
                     protein"
                     /calculated_mol_wt=51582
     Region          18..39
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          49..135
                     /region_name="RRM1_CELF3_4_5_6"
                     /note="RNA recognition motif 1 (RRM1) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12632"
                     /db_xref="CDD:410041"
     Site            order(55,57,59..60,63,82,84,86,95..97,99,129,131)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410041"
     Region          121..149
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          150..230
                     /region_name="RRM2_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12635"
                     /db_xref="CDD:410043"
     Site            order(152,154,156..157,160,179,181,183,191..193,195,225,
                     227)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410043"
     Region          238..257
                     /region_name="Necessary for TNNT2 exon 5 inclusion.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          415..473
                     /region_name="RRM_SF"
                     /note="RNA recognition motif (RRM) superfamily; cl17169"
                     /db_xref="CDD:450164"
     CDS             1..484
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /coded_by="NM_001362323.1:531..1985"
                     /note="isoform 40 is encoded by transcript variant 43"
                     /db_xref="GeneID:108013"
                     /db_xref="MGI:MGI:1932407"
ORIGIN      
        1 myikmatlan gqadnaslst nglgsspgsa ghmnglshsp gnpstipmkd hdaiklfigq
       61 iprnldekdl kplfeefgki yeltvlkdrf tgmhkgcafl tyceresalk aqsalheqkt
      121 lpgmnrpiqv kpadsesrgg ssclrqppsh rklfvgmlnk qqseddvrrl feafgnieec
      181 tilrgpdgns kgcafvkyss haeaqaaina lhgsqtmpga ssslvvkfad tdkertmrrm
      241 qqmagqmgmf npmaipfgay gayaqamqqq aalmasvaqg gylnpmaafa aaqmqqmaal
      301 nmnglaaapm tptsggstpp gitapavpsi pspigvngft glppqangqp aaeavfangi
      361 hpypaqspta adplqqayag vqqyagpaay paaygqisqa fpqpppmipq qqregpegcn
      421 lliyhlpqef gdaelmqmfl pfgfvsfdnp asaqtaiqam ngfqigmkrl kvqlkrpkda
      481 nrpy
//
LOCUS       NP_001124492             428 aa            linear   ROD 09-OCT-2023
DEFINITION  glial fibrillary acidic protein isoform 1 [Mus musculus].
ACCESSION   NP_001124492
VERSION     NP_001124492.1
DBSOURCE    REFSEQ: accession NM_001131020.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 428)
  AUTHORS   Yammine SZ, Burns I, Gosio J, Peluso A, Merritt DM, Innes B, Coles
            BLK, Yan WR, Bader GD, Morshead CM and van der Kooy D.
  TITLE     Fate Specification of GFAP-Negative Primitive Neural Stem Cells and
            Their Progeny at Clonal Resolution
  JOURNAL   Stem Cells Dev 32 (19-20), 606-621 (2023)
   PUBMED   37551982
  REMARK    GeneRIF: Fate Specification of GFAP-Negative Primitive Neural Stem
            Cells and Their Progeny at Clonal Resolution.
REFERENCE   2  (residues 1 to 428)
  AUTHORS   Montillot C, Skutunova E, Ayushma, Dubied M, Lahmar A, Nguyen S,
            Peerally B, Prin F, Duffourd Y, Thauvin-Robinet C, Duplomb L, Wang
            H, Ansar M, Faivre L, Navarro N, Minocha S, Collins SC and Yalcin
            B.
  TITLE     Characterization of Vps13b-mutant mice reveals neuroanatomical and
            behavioral phenotypes with females less affected
  JOURNAL   Neurobiol Dis 185, 106259 (2023)
   PUBMED   37573958
REFERENCE   3  (residues 1 to 428)
  AUTHORS   Cao B, Xia Y, Cai Z, Wang Z, Tang C and Song Y.
  TITLE     Construction of a Brain-specific SLC23A2 Gene Knockout Mice Model
  JOURNAL   Neuroscience 524, 137-148 (2023)
   PUBMED   37330196
REFERENCE   4  (residues 1 to 428)
  AUTHORS   Hu M, Bodnar B, Zhang Y, Xie F, Li F, Li S, Zhao J, Zhao R,
            Gedupoori N, Mo Y, Lin L, Li X, Meng W, Yang X, Wang H, Barbe MF,
            Srinivasan S, Bethea JR, Mo X, Xu H and Hu W.
  TITLE     Defective neurite elongation and branching in Nibp/Trappc9
            deficient zebrafish and mice
  JOURNAL   Int J Biol Sci 19 (10), 3226-3248 (2023)
   PUBMED   37416774
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 428)
  AUTHORS   Li J, Jiang H, Mu Y, Wei Z, Ma A, Sun M, Zhao J, Zhu C and Chen X.
  TITLE     SRSF10 regulates proliferation of neural progenitor cells and
            affects neurogenesis in developing mouse neocortex
  JOURNAL   iScience 26 (7), 107042 (2023)
   PUBMED   37360696
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 428)
  AUTHORS   Miragall F, Hwang TK, Traub O, Hertzberg EL and Dermietzel R.
  TITLE     Expression of connexins in the developing olfactory system of the
            mouse
  JOURNAL   J Comp Neurol 325 (3), 359-378 (1992)
   PUBMED   1332989
REFERENCE   7  (residues 1 to 428)
  AUTHORS   Nonaka M, Matsuda Y, Shiroishi T, Moriwaki K, Nonaka M and
            Natsuume-Sakai S.
  TITLE     Molecular cloning of mouse beta 2-glycoprotein I and mapping of the
            gene to chromosome 11
  JOURNAL   Genomics 13 (4), 1082-1087 (1992)
   PUBMED   1339387
REFERENCE   8  (residues 1 to 428)
  AUTHORS   Dietrich W, Katz H, Lincoln SE, Shin HS, Friedman J, Dracopoli NC
            and Lander ES.
  TITLE     A genetic map of the mouse suitable for typing intraspecific
            crosses
  JOURNAL   Genetics 131 (2), 423-447 (1992)
   PUBMED   1353738
REFERENCE   9  (residues 1 to 428)
  AUTHORS   Karolyi IJ, Guenet JL, Rey-Campos J and Camper SA.
  TITLE     The gene coding for variant hepatic nuclear factor 1 (Tcf-2), maps
            between the Edp-1 and Erba genes on mouse chromosome 11
  JOURNAL   Mamm Genome 3 (3), 184-185 (1992)
   PUBMED   1352161
REFERENCE   10 (residues 1 to 428)
  AUTHORS   Dyson PJ, de Smet C, Knight AM, Simon-Chazottes D, Guenet JL and
            Boon T.
  TITLE     Mapping of the genes encoding tum- transplantation antigens P91A,
            P35B, and P198
  JOURNAL   Immunogenetics 35 (5), 316-323 (1992)
   PUBMED   1348494
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC139357.1, AK140151.1 and BU700210.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK140151.1, SRR7652917.688090.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..428
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 66.48 cM"
     Protein         1..428
                     /product="glial fibrillary acidic protein isoform 1"
                     /note="intermediate filament protein"
                     /calculated_mol_wt=49234
     Region          4..63
                     /region_name="Filament_head"
                     /note="Intermediate filament head (DNA binding) region;
                     pfam04732"
                     /db_xref="CDD:428095"
     Region          65..373
                     /region_name="Filament"
                     /note="Intermediate filament protein; pfam00038"
                     /db_xref="CDD:425436"
     CDS             1..428
                     /gene="Gfap"
                     /coded_by="NM_001131020.1:84..1370"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS48950.1"
                     /db_xref="GeneID:14580"
                     /db_xref="MGI:MGI:95697"
ORIGIN      
        1 merrritsar rsyasetvvr glgpsrqlgt mprfslsrmt pplparvdfs lagalnagfk
       61 etraseraem melndrfasy iekvrfleqq nkalaaelnq lrakeptkla dvyqaelrel
      121 rlrldqltan sarleverdn faqdlgtlrq klqdetnlrl eaennlaayr qeadeatlar
      181 vdlerkvesl eeeiqflrki yeeevrelre qlaqqqvhve mdvakpdlta alreirtqye
      241 avatsnmqet eewyrskfad ltdaasrnae llrqakhean dyrrqlqalt cdleslrgtn
      301 eslerqmreq eerharesas yqealarlee egqslkeema rhlqeyqdll nvklaldiei
      361 atyrkllege enritipvqt fsnlqirggk stkegegqkv trplkrltiq vvpiqahqie
      421 ngalpalp
//
LOCUS       NP_001390656             735 aa            linear   ROD 09-OCT-2023
DEFINITION  transcriptional repressor CTCF isoform 2 [Mus musculus].
ACCESSION   NP_001390656
VERSION     NP_001390656.1
DBSOURCE    REFSEQ: accession NM_001403727.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 735)
  AUTHORS   Hewitt SC, Gruzdev A, Willson CJ, Wu SP, Lydon JP, Galjart N and
            DeMayo FJ.
  TITLE     Chromatin architectural factor CTCF is essential for
            progesterone-dependent uterine maturation
  JOURNAL   FASEB J 37 (8), e23103 (2023)
   PUBMED   37489832
  REMARK    GeneRIF: Chromatin architectural factor CTCF is essential for
            progesterone-dependent uterine maturation.
REFERENCE   2  (residues 1 to 735)
  AUTHORS   Smits WK, Vermeulen C, Hagelaar R, Kimura S, Vroegindeweij EM,
            Buijs-Gladdines JGCAM, van de Geer E, Verstegen MJAM, Splinter E,
            van Reijmersdal SV, Buijs A, Galjart N, van Eyndhoven W, van Min M,
            Kuiper R, Kemmeren P, Mullighan CG, de Laat W and Meijerink JPP.
  TITLE     Elevated enhancer-oncogene contacts and higher oncogene expression
            levels by recurrent CTCF inactivating mutations in acute T cell
            leukemia
  JOURNAL   Cell Rep 42 (4), 112373 (2023)
   PUBMED   37060567
REFERENCE   3  (residues 1 to 735)
  AUTHORS   Wang B, Ji L and Bian Q.
  TITLE     SATB1 regulates 3D genome architecture in T cells by constraining
            chromatin interactions surrounding CTCF-binding sites
  JOURNAL   Cell Rep 42 (4), 112323 (2023)
   PUBMED   37000624
  REMARK    GeneRIF: SATB1 regulates 3D genome architecture in T cells by
            constraining chromatin interactions surrounding CTCF-binding sites.
REFERENCE   4  (residues 1 to 735)
  AUTHORS   Marina-Zarate E, Rodriguez-Ronchel A, Gomez MJ, Sanchez-Cabo F and
            Ramiro AR.
  TITLE     Low-affinity CTCF binding drives transcriptional regulation whereas
            high-affinity binding encompasses architectural functions
  JOURNAL   iScience 26 (3), 106106 (2023)
   PUBMED   36852270
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 735)
  AUTHORS   Hsieh TS, Cattoglio C, Slobodyanyuk E, Hansen AS, Darzacq X and
            Tjian R.
  TITLE     Enhancer-promoter interactions and transcription are largely
            maintained upon acute loss of CTCF, cohesin, WAPL or YY1
  JOURNAL   Nat Genet 54 (12), 1919-1932 (2022)
   PUBMED   36471071
  REMARK    GeneRIF: Enhancer-promoter interactions and transcription are
            largely maintained upon acute loss of CTCF, cohesin, WAPL or YY1.
REFERENCE   6  (residues 1 to 735)
  AUTHORS   Farrell CM, West AG and Felsenfeld G.
  TITLE     Conserved CTCF insulator elements flank the mouse and human
            beta-globin loci
  JOURNAL   Mol Cell Biol 22 (11), 3820-3831 (2002)
   PUBMED   11997516
  REMARK    GeneRIF: Conserved CTCF insulator elements flank the mouse and
            human beta-globin loci.
REFERENCE   7  (residues 1 to 735)
  AUTHORS   Burke LJ, Hollemann T, Pieler T and Renkawitz R.
  TITLE     Molecular cloning and expression of the chromatin insulator protein
            CTCF in Xenopus laevis
  JOURNAL   Mech Dev 113 (1), 95-98 (2002)
   PUBMED   11900981
REFERENCE   8  (residues 1 to 735)
  AUTHORS   Chao W, Huynh KD, Spencer RJ, Davidow LS and Lee JT.
  TITLE     CTCF, a candidate trans-acting factor for X-inactivation choice
  JOURNAL   Science 295 (5553), 345-347 (2002)
   PUBMED   11743158
  REMARK    GeneRIF: It's proposed that Tsix and CTCF together establish a
            regulatable epigenetic switch for X-inactivation.
REFERENCE   9  (residues 1 to 735)
  AUTHORS   Lutz M, Burke LJ, Barreto G, Goeman F, Greb H, Arnold R,
            Schultheiss H, Brehm A, Kouzarides T, Lobanenkov V and Renkawitz R.
  TITLE     Transcriptional repression by the insulator protein CTCF involves
            histone deacetylases
  JOURNAL   Nucleic Acids Res 28 (8), 1707-1713 (2000)
   PUBMED   10734189
REFERENCE   10 (residues 1 to 735)
  AUTHORS   Filippova GN, Fagerlie S, Klenova EM, Myers C, Dehner Y, Goodwin G,
            Neiman PE, Collins SJ and Lobanenkov VV.
  TITLE     An exceptionally conserved transcriptional repressor, CTCF, employs
            different combinations of zinc fingers to bind diverged promoter
            sequences of avian and mammalian c-myc oncogenes
  JOURNAL   Mol Cell Biol 16 (6), 2802-2813 (1996)
   PUBMED   8649389
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127419.3 and AC152826.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422597.592058.1,
                                           SRR13422598.1180692.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..735
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.04 cM"
     Protein         1..735
                     /product="transcriptional repressor CTCF isoform 2"
                     /note="transcriptional repressor CTCF; CTCFL paralog;
                     11-zinc finger protein"
                     /calculated_mol_wt=83486
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          180..211
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61164.2)"
     Region          266..289
                     /region_name="zf-H2C2_5"
                     /note="C2H2-type zinc-finger domain; pfam13909"
                     /db_xref="CDD:404746"
     Region          268..288
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(268,271,284,288)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:275368"
     Site            order(273,275,277,279..280,283..284,287,301,303,307..308,
                     311..312,315,329,331,333,335..336,339..340,346)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          280..305
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:433230"
     Site            289
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          296..316
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          309..333
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:433230"
     Site            317
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          324..347
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          351..375
                     /region_name="zf-H2C2_5"
                     /note="C2H2-type zinc-finger domain; pfam13909"
                     /db_xref="CDD:404746"
     Region          353..373
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          <366..500
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Site            374
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          381..401
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            402
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          409..426
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          439..457
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          469..489
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(469,472,485,489)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:275368"
     Site            order(474,476,478,480..481,484..485,488,502,504,508..509,
                     512..513,516,530,532,534,536..537,540..541,545)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          497..517
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          509..534
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:433230"
     Region          525..546
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          557..573
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            609
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Site            610
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Site            612
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          698..725
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61164.2)"
     CDS             1..735
                     /gene="Ctcf"
                     /coded_by="NM_001403727.1:143..2350"
                     /note="isoform 2 is encoded by transcript variant 7"
                     /db_xref="GeneID:13018"
                     /db_xref="MGI:MGI:109447"
ORIGIN      
        1 megeaveaiv eesetfikgk erktyqrrre ggqeedachl pqnqtdggev vqdvnssvqm
       61 vmmeqldptl lqmktevmeg tvapeaeaav ddtqiitlqv vnmeeqpini gelqlvqvpv
      121 pvtvpvatts veelqgayen evskeglaes epmichtlpl pegfqvvkvg angevetleq
      181 gelppqedss wqkdpdyqpp akktkktkks klryteegkd vdvsvydfee eqqegllsev
      241 naekvvgnmk ppkptkikkk gvkktfqcel csytcprrsn ldrhmkshtd erphkchlcg
      301 rafrtvtllr nhlnthtgtr phkcpdcdma fvtsgelvrh rrykhthekp fkcsmcdyas
      361 vevsklkrhi rshtgerpfq cslcsyasrd tyklkrhmrt hsgekpyecy icharftqsg
      421 tmkmhilqkh tenvakfhcp hcdtviarks dlgvhlrkqh syieqgkkcr ycdavfhery
      481 aliqhqkshk nekrfkcdqc dyacrqerhm imhkrthtge kpyacshcdk tfrqkqlldm
      541 hfkryhdpnf vpaafvcskc gktftrrntm arhadncagp dgvegengge tkkskrgrkr
      601 kmrskkedss dsenaepdld dneeeeepav eiepepepqp qpppppqpva papppakkrr
      661 grppgrtnqp kqnqptaiiq vedqntgaie niivevkkep daepaegeee eaqaattdap
      721 ngdltpemil smmdr
//
LOCUS       NP_001139765             485 aa            linear   ROD 09-OCT-2023
DEFINITION  CUGBP Elav-like family member 4 isoform 35 [Mus musculus].
ACCESSION   NP_001139765 XP_001473171
VERSION     NP_001139765.1
DBSOURCE    REFSEQ: accession NM_001146293.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 485)
  AUTHORS   Salamon I, Park Y, Miskic T, Kopic J, Matteson P, Page NF, Roque A,
            McAuliffe GW, Favate J, Garcia-Forn M, Shah P, Judas M, Millonig
            JH, Kostovic I, De Rubeis S, Hart RP, Krsnik Z and Rasin MR.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    GeneRIF: Celf4 controls mRNA translation underlying synaptic
            development in the prenatal mammalian neocortex.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 485)
  AUTHORS   Shen Y, Zhang C, Xiao K, Liu D and Xie G.
  TITLE     CELF4 regulates spine formation and depression-like behaviors of
            mice
  JOURNAL   Biochem Biophys Res Commun 605, 39-44 (2022)
   PUBMED   35306363
  REMARK    GeneRIF: CELF4 regulates spine formation and depression-like
            behaviors of mice.
REFERENCE   3  (residues 1 to 485)
  AUTHORS   Moreau MX, Saillour Y, Cwetsch AW, Pierani A and Causeret F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   4  (residues 1 to 485)
  AUTHORS   Li C, Li X, Bi Z, Sugino K, Wang G, Zhu T and Liu Z.
  TITLE     Comprehensive transcriptome analysis of cochlear spiral ganglion
            neurons at multiple ages
  JOURNAL   Elife 9, e50491 (2020)
   PUBMED   31913118
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 485)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 485)
  AUTHORS   Ladd AN, Taffet G, Hartley C, Kearney DL and Cooper TA.
  TITLE     Cardiac tissue-specific repression of CELF activity disrupts
            alternative splicing and causes cardiomyopathy
  JOURNAL   Mol Cell Biol 25 (14), 6267-6278 (2005)
   PUBMED   15988035
  REMARK    GeneRIF: CELF protein activity is required for normal alternative
            splicing in the heart in vivo and normal CELF-mediated alternative
            splicing regulation is in turn required for normal cardiac
            function.
REFERENCE   7  (residues 1 to 485)
  AUTHORS   Meins M, Schlickum S, Wilhelm C, Missbach J, Yadav S, Glaser B,
            Grzmil M, Burfeind P and Laccone F.
  TITLE     Identification and characterization of murine Brunol4, a new member
            of the elav/bruno family
  JOURNAL   Cytogenet Genome Res 97 (3-4), 254-260 (2002)
   PUBMED   12438720
  REMARK    GeneRIF: cloning and characterization
REFERENCE   8  (residues 1 to 485)
  AUTHORS   Ladd AN, Charlet N and Cooper TA.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   9  (residues 1 to 485)
  AUTHORS   Good PJ, Chen Q, Warner SJ and Herring DC.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
REFERENCE   10 (residues 1 to 485)
  AUTHORS   Yulug IG, Egan SE, See CG and Fisher EM.
  TITLE     Mapping GRB2, a signal transduction gene in the human and the mouse
  JOURNAL   Genomics 22 (2), 313-318 (1994)
   PUBMED   7806216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121094.8, AK048427.1, BC052744.1, AF515450.1, CX242398.1,
            AK038871.1 and AK078071.1.
            
            On May 1, 2009 this sequence version replaced XP_001473171.1.
            
            Transcript Variant: This variant (2) encodes isoform (37, also
            known as B).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052744.1, SRR1660825.48798.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 13.92 cM"
     Protein         1..485
                     /product="CUGBP Elav-like family member 4 isoform 35"
                     /note="CUG-BP- and ETR-3-like factor 4; bruno-like protein
                     4; RNA-binding protein BRUNOL-4; bruno-like 4, RNA binding
                     protein"
                     /calculated_mol_wt=51730
     Region          1..298
                     /region_name="Sufficient for RNA-binding and MSE-dependent
                     splicing activity. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          18..39
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          49..135
                     /region_name="RRM1_CELF3_4_5_6"
                     /note="RNA recognition motif 1 (RRM1) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12632"
                     /db_xref="CDD:410041"
     Site            order(55,57,59..60,63,82,84,86,95..97,99,129,131)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410041"
     Region          <56..378
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     Region          121..149
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          151..231
                     /region_name="RRM2_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12635"
                     /db_xref="CDD:410043"
     Site            order(153,155,157..158,161,180,182,184,192..194,196,226,
                     228)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410043"
     Region          239..258
                     /region_name="Necessary for TNNT2 exon 5 inclusion.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          416..474
                     /region_name="RRM_SF"
                     /note="RNA recognition motif (RRM) superfamily; cl17169"
                     /db_xref="CDD:450164"
     CDS             1..485
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /coded_by="NM_001146293.2:531..1988"
                     /note="isoform 35 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS89205.1"
                     /db_xref="GeneID:108013"
                     /db_xref="MGI:MGI:1932407"
ORIGIN      
        1 myikmatlan gqadnaslst nglgsspgsa ghmnglshsp gnpstipmkd hdaiklfigq
       61 iprnldekdl kplfeefgki yeltvlkdrf tgmhkgcafl tyceresalk aqsalheqkt
      121 lpgmnrpiqv kpadsesrgg ssclrqppsq drklfvgmln kqqseddvrr lfeafgniee
      181 ctilrgpdgn skgcafvkys shaeaqaain alhgsqtmpg assslvvkfa dtdkertmrr
      241 mqqmagqmgm fnpmaipfga ygayaqalmq qqaalmasva qggylnpmaa faaaqmqqma
      301 alnmnglaaa pmtptsggst ppgitapavp sipspigvng ftglppqang qpaaeavfan
      361 gihpypaqsp taadplqqay agvqqyagpa ypaaygqisq afpqpppmip qqqregpegc
      421 nlliyhlpqe fgdaelmqmf lpfgfvsfdn pasaqtaiqa mngfqigmkr lkvqlkrpkd
      481 anrpy
//
LOCUS       NP_997564                140 aa            linear   ROD 09-OCT-2023
DEFINITION  bcl-2-like protein 11 isoform 2 [Mus musculus].
ACCESSION   NP_997564
VERSION     NP_997564.1
DBSOURCE    REFSEQ: accession NM_207681.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 140)
  AUTHORS   Jiang M, Wang XB and Jiang S.
  TITLE     circ_0000018 downregulation peripherally ameliorates
            neuroprotection against acute ischemic stroke through the
            miR-871/BCL2L11 axis
  JOURNAL   Mol Med Rep 28 (5) (2023)
   PUBMED   37772397
  REMARK    GeneRIF: circ_0000018 downregulation peripherally ameliorates
            neuroprotection against acute ischemic stroke through the
            miR-871/BCL2L11 axis.
REFERENCE   2  (residues 1 to 140)
  AUTHORS   Lu Y, Tang K, Wang S, Tian Z, Fan Y, Li B, Wang M, Zhao J and Xie
            J.
  TITLE     Dach1 deficiency drives alveolar epithelium apoptosis in pulmonary
            fibrosis via modulating C-Jun/Bim activity
  JOURNAL   Transl Res 257, 54-65 (2023)
   PUBMED   36754276
  REMARK    GeneRIF: Dach1 deficiency drives alveolar epithelium apoptosis in
            pulmonary fibrosis via modulating C-Jun/Bim activity.
REFERENCE   3  (residues 1 to 140)
  AUTHORS   Nguyen HV, Vandenberg CJ, Robati MR, Ng AP and Cory S.
  TITLE     MNT suppresses T cell apoptosis via BIM and is critical for T
            lymphomagenesis
  JOURNAL   Cell Death Differ 30 (4), 1018-1032 (2023)
   PUBMED   36755068
  REMARK    GeneRIF: MNT suppresses T cell apoptosis via BIM and is critical
            for T lymphomagenesis.
REFERENCE   4  (residues 1 to 140)
  AUTHORS   Chen H, Bai Y, Kobayashi M, Xiao S, Cai W, Barajas S, Chen S, Miao
            J, Meke FN, Vemula S, Ropa JP, Croop JM, Boswell HS, Wan J, Jia Y,
            Liu H, Li LS, Altman JK, Eklund EA, Ji P, Tong W, Band H, Huang DT,
            Platanias LC, Zhang ZY and Liu Y.
  TITLE     PRL2 phosphatase enhances oncogenic FLT3 signaling via
            dephosphorylation of the E3 ubiquitin ligase CBL at tyrosine 371
  JOURNAL   Blood 141 (3), 244-259 (2023)
   PUBMED   36206490
REFERENCE   5  (residues 1 to 140)
  AUTHORS   Brahma MK, Xiao P, Popa M, Negueruela J, Vandenbempt V, Demine S,
            Cardozo AK and Gurzov EN.
  TITLE     Nova1 or Bim Deficiency in Pancreatic beta-Cells Does Not Alter
            Multiple Low-Dose Streptozotocin-Induced Diabetes and Diet-Induced
            Obesity in Mice
  JOURNAL   Nutrients 14 (18), 3866 (2022)
   PUBMED   36145242
  REMARK    GeneRIF: Nova1 or Bim Deficiency in Pancreatic beta-Cells Does Not
            Alter Multiple Low-Dose Streptozotocin-Induced Diabetes and
            Diet-Induced Obesity in Mice.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 140)
  AUTHORS   Bouillet P, Zhang LC, Huang DC, Webb GC, Bottema CD, Shore P, Eyre
            HJ, Sutherland GR and Adams JM.
  TITLE     Gene structure alternative splicing, and chromosomal localization
            of pro-apoptotic Bcl-2 relative Bim
  JOURNAL   Mamm Genome 12 (2), 163-168 (2001)
   PUBMED   11210187
REFERENCE   7  (residues 1 to 140)
  AUTHORS   Bouillet P, Metcalf D, Huang DC, Tarlinton DM, Kay TW, Kontgen F,
            Adams JM and Strasser A.
  TITLE     Proapoptotic Bcl-2 relative Bim required for certain apoptotic
            responses, leukocyte homeostasis, and to preclude autoimmunity
  JOURNAL   Science 286 (5445), 1735-1738 (1999)
   PUBMED   10576740
REFERENCE   8  (residues 1 to 140)
  AUTHORS   Puthalakath H, Huang DC, O'Reilly LA, King SM and Strasser A.
  TITLE     The proapoptotic activity of the Bcl-2 family member Bim is
            regulated by interaction with the dynein motor complex
  JOURNAL   Mol Cell 3 (3), 287-296 (1999)
   PUBMED   10198631
REFERENCE   9  (residues 1 to 140)
  AUTHORS   Reed JC.
  TITLE     Bcl-2 family proteins
  JOURNAL   Oncogene 17 (25), 3225-3236 (1998)
   PUBMED   9916985
  REMARK    Review article
REFERENCE   10 (residues 1 to 140)
  AUTHORS   O'Connor L, Strasser A, O'Reilly LA, Hausmann G, Adams JM, Cory S
            and Huang DC.
  TITLE     Bim: a novel member of the Bcl-2 family that promotes apoptosis
  JOURNAL   EMBO J 17 (2), 384-395 (1998)
   PUBMED   9430630
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK037885.1, AK050192.1, AK082613.1, CB521709.1, CA321725.1,
            AA881651.1 and BE136124.1.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            segment in the central coding region, compared to variant 1,
            resulting in an isoform (2) that is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK050192.1, BB653788.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..140
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 62.23 cM"
     Protein         1..140
                     /product="bcl-2-like protein 11 isoform 2"
                     /note="bcl-2-like protein 11; bcl2-interacting mediator of
                     cell death; Bcl2 interacting mediator of cell death;
                     BCL2-like 11 (apoptosis facilitator)"
                     /calculated_mol_wt=16074
     Region          4..40
                     /region_name="Bim_N"
                     /note="Bim protein N-terminus; pfam06773"
                     /db_xref="CDD:429111"
     Region          73..108
                     /region_name="Bclx_interact"
                     /note="Bcl-x interacting, BH3 domain; pfam08945"
                     /db_xref="CDD:430337"
     CDS             1..140
                     /gene="Bcl2l11"
                     /gene_synonym="1500006F24Rik; bcl2-L-11; Bim; Bod"
                     /coded_by="NM_207681.2:229..651"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS16714.1"
                     /db_xref="GeneID:12125"
                     /db_xref="MGI:MGI:1197519"
ORIGIN      
        1 makqpsdvss ecdreggqlq paerppqlrp gaptslqtep qdrspapmsc dkstqtpspp
       61 cqafnhylsa masirqsqee pedlrpeiri aqelrrigde fnetytrrvf andyreaedh
      121 pqmvilqllr fifrlvwrrh
//
LOCUS       NP_899133                895 aa            linear   ROD 09-OCT-2023
DEFINITION  serine-rich coiled-coil domain-containing protein 1 [Mus musculus].
ACCESSION   NP_899133 XP_913769 XP_993292
VERSION     NP_899133.2
DBSOURCE    REFSEQ: accession NM_183310.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 895)
  AUTHORS   Chen K, Chen X, Lang C, Yuan X, Huang J, Li Z, Xu M, Wu K, Zhou C,
            Li Q, Zhu C, Liu L and Shang X.
  TITLE     CircFam190a: a critical positive regulator of osteoclast
            differentiation via enhancement of the AKT1/HSP90beta complex
  JOURNAL   Exp Mol Med 55 (9), 2051-2066 (2023)
   PUBMED   37653038
  REMARK    GeneRIF: CircFam190a: a critical positive regulator of osteoclast
            differentiation via enhancement of the AKT1/HSP90beta complex.
REFERENCE   2  (residues 1 to 895)
  AUTHORS   Okazaki N, F-Kikuno R, Ohara R, Inamoto S, Koseki H, Hiraoka S,
            Saga Y, Seino S, Nishimura M, Kaisho T, Hoshino K, Kitamura H,
            Nagase T, Ohara O and Koga H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB646598.1, BB634602.1, BC107398.2 and AK173231.1.
            
            On or before Aug 21, 2009 this sequence version replaced
            XP_913769.1, XP_993292.1, NP_899133.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164131,
                              SAMN01164132 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..895
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 29.24 cM"
     Protein         1..895
                     /product="serine-rich coiled-coil domain-containing
                     protein 1"
                     /note="protein FAM190A; family with sequence similarity
                     190, member A; coiled-coil serine-rich protein 1"
                     /calculated_mol_wt=98087
     Region          1..142
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C0C4.2)"
     Region          154..177
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C0C4.2)"
     Region          332..394
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C0C4.2)"
     Region          459..497
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C0C4.2)"
     Region          731..754
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C0C4.2)"
     CDS             1..895
                     /gene="Ccser1"
                     /gene_synonym="6230405M12Rik; C130092O11Rik; Fam190a"
                     /coded_by="NM_183310.2:371..3058"
                     /db_xref="CCDS:CCDS51800.1"
                     /db_xref="GeneID:232035"
                     /db_xref="MGI:MGI:3045354"
ORIGIN      
        1 mgdsgsrrct lvsrlpifrk sinrrhdslp sspsssntag vhssspsstn sssgstgkrr
       61 sifrapsisf hhkkgsepkp epteqnlsis ngaqpshsnm qklsleehvk trgrhsvgfs
      121 ssrskkitrs ltedfereke pstnknvfin clssgrsegd dsgfteeqsr rsikqstkkl
      181 lpksfsshyk fcksvpqsqs tsliqqpefs laiaqyqeqe aalgrpspsc svdvterags
      241 slqspllsad lttaqtpsef laltedslse adafpksgst ashcdnfghn datsqptssl
      301 tavsktkmef vgtapcvmsp gryrlegrcs telhsspetp agnrrevslq stelsvgngs
      361 dpethlpahh qrgesplaha gepalrtgsp rtlgsydqhk alaerfkgvh pvsdsrvips
      421 sgdhvfnkts ygyeasaakv lasslspyre gryierrlrs ssegtagssr mvlkpkdghv
      481 easslrkhrt gsssskmnsl dvlnhlgsce ldeddlmldl efleeqnlqp pvcredschs
      541 vmsctavlls pvdpgkevnm leepkcpeps kqnlslritk dtdqearcsh vscmpnspsa
      601 dwpqqgveen ggidslpfrl mlqectavkt lllkmkrvlq esdvspssst tslpisplte
      661 eplpfkditr decsmlrlql kdrdelisql qaelekvqhl qkafasrvdk stqtellgcd
      721 glslkrleav qggretthrn rtmsqshstr drkaihtpte drfrystadq tspyknicql
      781 pglclsnflk dkelggvmkh trgnheavts emtqnsrttm gqsflkaaak peglpmfsek
      841 pkdpaalsrq hstftgrfgq pprgpislht ysrknvflhh nlhttefqtl gqqdg
//
LOCUS       NP_001397162             481 aa            linear   ROD 09-OCT-2023
DEFINITION  nuclear respiratory factor 1 isoform j [Mus musculus].
ACCESSION   NP_001397162
VERSION     NP_001397162.1
DBSOURCE    REFSEQ: accession NM_001410233.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 481)
  AUTHORS   Cheng C, Tian Y, Yang R, Guo W, Xiao K, Zhang F, Tian J, Deng Z,
            Yang W, Yang H and Zhou Z.
  TITLE     miR-5581 Contributes to Osteoarthritis by Targeting NRF1 to Disturb
            the Proliferation and Functions of Chondrocytes
  JOURNAL   Am J Pathol 193 (9), 1234-1247 (2023)
   PUBMED   37611970
  REMARK    GeneRIF: miR-5581 Contributes to Osteoarthritis by Targeting NRF1
            to Disturb the Proliferation and Functions of Chondrocytes.
REFERENCE   2  (residues 1 to 481)
  AUTHORS   Meng Z, Liang B, Wu Y, Liu C, Wang H, Du Y, Gan L, Gao E, Lau WB,
            Christopher TA, Lopez BL, Koch WJ, Ma X, Zhao F, Wang Y and Zhao J.
  TITLE     Hypoadiponectinemia-induced upregulation of microRNA449b
            downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury
            in diabetic mice
  JOURNAL   J Mol Cell Cardiol 182, 1-14 (2023)
   PUBMED   37437402
  REMARK    GeneRIF: Hypoadiponectinemia-induced upregulation of microRNA449b
            downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury
            in diabetic mice.
REFERENCE   3  (residues 1 to 481)
  AUTHORS   Zhao T, Zhang J, Lei H, Meng Y, Cheng H, Zhao Y, Geng G, Mu C, Chen
            L, Liu Q, Luo Q, Zhang C, Long Y, Su J, Wang Y, Li Z, Sun J, Chen
            G, Li Y, Liao X, Shang Y, Hu G, Chen Q and Zhu Y.
  TITLE     NRF1-mediated mitochondrial biogenesis antagonizes innate antiviral
            immunity
  JOURNAL   EMBO J 42 (16), e113258 (2023)
   PUBMED   37409632
  REMARK    GeneRIF: NRF1-mediated mitochondrial biogenesis antagonizes innate
            antiviral immunity.
REFERENCE   4  (residues 1 to 481)
  AUTHORS   Akl MG, Baccetto R, Stebbings BM, Li L and Widenmaier SB.
  TITLE     Euglycemia is affected by stress defense factor hepatocyte NRF1,
            but not NRF2
  JOURNAL   Biochem Biophys Res Commun 668, 96-103 (2023)
   PUBMED   37245295
  REMARK    GeneRIF: Euglycemia is affected by stress defense factor hepatocyte
            NRF1, but not NRF2.
REFERENCE   5  (residues 1 to 481)
  AUTHORS   Akl MG, Li L, Baccetto R, Phanse S, Zhang Q, Trites MJ, McDonald S,
            Aoki H, Babu M and Widenmaier SB.
  TITLE     Complementary gene regulation by NRF1 and NRF2 protects against
            hepatic cholesterol overload
  JOURNAL   Cell Rep 42 (4), 112399 (2023)
   PUBMED   37060561
  REMARK    GeneRIF: Complementary gene regulation by NRF1 and NRF2 protects
            against hepatic cholesterol overload.
            Erratum:[Cell Rep. 2023 Jul 25;42(7):112872. PMID: 37454293]
REFERENCE   6  (residues 1 to 481)
  AUTHORS   Carmona MC, Iglesias R, Obregon MJ, Darlington GJ, Villarroya F and
            Giralt M.
  TITLE     Mitochondrial biogenesis and thyroid status maturation in brown fat
            require CCAAT/enhancer-binding protein alpha
  JOURNAL   J Biol Chem 277 (24), 21489-21498 (2002)
   PUBMED   11940593
REFERENCE   7  (residues 1 to 481)
  AUTHORS   Huo L and Scarpulla RC.
  TITLE     Mitochondrial DNA instability and peri-implantation lethality
            associated with targeted disruption of nuclear respiratory factor 1
            in mice
  JOURNAL   Mol Cell Biol 21 (2), 644-654 (2001)
   PUBMED   11134350
REFERENCE   8  (residues 1 to 481)
  AUTHORS   Schaefer L, Engman H and Miller JB.
  TITLE     Coding sequence, chromosomal localization, and expression pattern
            of Nrf1: the mouse homolog of Drosophila erect wing
  JOURNAL   Mamm Genome 11 (2), 104-110 (2000)
   PUBMED   10656923
REFERENCE   9  (residues 1 to 481)
  AUTHORS   Huo L and Scarpulla RC.
  TITLE     Multiple 5'-untranslated exons in the nuclear respiratory factor 1
            gene span 47 kb and contribute to transcript heterogeneity and
            translational efficiency
  JOURNAL   Gene 233 (1-2), 213-224 (1999)
   PUBMED   10375638
REFERENCE   10 (residues 1 to 481)
  AUTHORS   Virbasius CA, Virbasius JV and Scarpulla RC.
  TITLE     NRF-1, an activator involved in nuclear-mitochondrial interactions,
            utilizes a new DNA-binding domain conserved in a family of
            developmental regulators
  JOURNAL   Genes Dev 7 (12A), 2431-2445 (1993)
   PUBMED   8253388
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134897.4 and AC153632.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253012.10499231.1,
                                           SRR17253014.3266979.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 12.47 cM"
     Protein         1..481
                     /product="nuclear respiratory factor 1 isoform j"
                     /note="NRF-1; alpha-pal; alpha palindromic-binding
                     protein"
                     /calculated_mol_wt=51463
     Region          87..283
                     /region_name="Nrf1_DNA-bind"
                     /note="NLS-binding and DNA-binding and dimerization
                     domains of Nrf1; pfam10491"
                     /db_xref="CDD:402218"
     CDS             1..481
                     /gene="Nrf1"
                     /gene_synonym="D6Ertd415e"
                     /coded_by="NM_001410233.1:271..1716"
                     /note="isoform j is encoded by transcript variant 23"
                     /db_xref="GeneID:18181"
                     /db_xref="MGI:MGI:1332235"
ORIGIN      
        1 meehgvtqte hmatieahav aqqvqqvhva tytehsmlsa dedspssped tsyddsdiln
       61 staadevtah laaagpvgma aaaavatgkk rkrphvfesn psirkrqqtr llrklratld
      121 eyttrvgqqa ivlcispskp npvfkvfgaa plenvvrkyk smiledlesa laehapapqe
      181 vnselpplti dgipvsvdkm tqaqlrafip emlkystgrg kpgwgkesck piwwpedipw
      241 anvrsdvrte eqkqrvswtq alrtivkncy kqhgredlly afedqqtqtq attthsiahl
      301 vpsqtvvqtf snpdgtvsli qvgtgatvat ladaselptt vtvaqvnysa vadgeveqnw
      361 atlqggemti qttqaseatq avaslaeaav aasqemqqga tvtmalnsea aahavatlae
      421 atlqgggqiv lsgetaaavg altgvqdang lfmadcggyk wilarrlqaq mefmhgpsak
      481 p
//
LOCUS       NP_001349258             474 aa            linear   ROD 09-OCT-2023
DEFINITION  CUGBP Elav-like family member 4 isoform 47 [Mus musculus].
ACCESSION   NP_001349258
VERSION     NP_001349258.1
DBSOURCE    REFSEQ: accession NM_001362329.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 474)
  AUTHORS   Salamon I, Park Y, Miskic T, Kopic J, Matteson P, Page NF, Roque A,
            McAuliffe GW, Favate J, Garcia-Forn M, Shah P, Judas M, Millonig
            JH, Kostovic I, De Rubeis S, Hart RP, Krsnik Z and Rasin MR.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    GeneRIF: Celf4 controls mRNA translation underlying synaptic
            development in the prenatal mammalian neocortex.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 474)
  AUTHORS   Shen Y, Zhang C, Xiao K, Liu D and Xie G.
  TITLE     CELF4 regulates spine formation and depression-like behaviors of
            mice
  JOURNAL   Biochem Biophys Res Commun 605, 39-44 (2022)
   PUBMED   35306363
  REMARK    GeneRIF: CELF4 regulates spine formation and depression-like
            behaviors of mice.
REFERENCE   3  (residues 1 to 474)
  AUTHORS   Moreau MX, Saillour Y, Cwetsch AW, Pierani A and Causeret F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   4  (residues 1 to 474)
  AUTHORS   Li C, Li X, Bi Z, Sugino K, Wang G, Zhu T and Liu Z.
  TITLE     Comprehensive transcriptome analysis of cochlear spiral ganglion
            neurons at multiple ages
  JOURNAL   Elife 9, e50491 (2020)
   PUBMED   31913118
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 474)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 474)
  AUTHORS   Ladd AN, Taffet G, Hartley C, Kearney DL and Cooper TA.
  TITLE     Cardiac tissue-specific repression of CELF activity disrupts
            alternative splicing and causes cardiomyopathy
  JOURNAL   Mol Cell Biol 25 (14), 6267-6278 (2005)
   PUBMED   15988035
  REMARK    GeneRIF: CELF protein activity is required for normal alternative
            splicing in the heart in vivo and normal CELF-mediated alternative
            splicing regulation is in turn required for normal cardiac
            function.
REFERENCE   7  (residues 1 to 474)
  AUTHORS   Meins M, Schlickum S, Wilhelm C, Missbach J, Yadav S, Glaser B,
            Grzmil M, Burfeind P and Laccone F.
  TITLE     Identification and characterization of murine Brunol4, a new member
            of the elav/bruno family
  JOURNAL   Cytogenet Genome Res 97 (3-4), 254-260 (2002)
   PUBMED   12438720
  REMARK    GeneRIF: cloning and characterization
REFERENCE   8  (residues 1 to 474)
  AUTHORS   Ladd AN, Charlet N and Cooper TA.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   9  (residues 1 to 474)
  AUTHORS   Good PJ, Chen Q, Warner SJ and Herring DC.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
REFERENCE   10 (residues 1 to 474)
  AUTHORS   Yulug IG, Egan SE, See CG and Fisher EM.
  TITLE     Mapping GRB2, a signal transduction gene in the human and the mouse
  JOURNAL   Genomics 22 (2), 313-318 (1994)
   PUBMED   7806216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121094.8 and AC144938.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.202000.1,
                                           SRR1660813.159558.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 13.92 cM"
     Protein         1..474
                     /product="CUGBP Elav-like family member 4 isoform 47"
                     /note="CUG-BP- and ETR-3-like factor 4; bruno-like protein
                     4; RNA-binding protein BRUNOL-4; bruno-like 4, RNA binding
                     protein"
                     /calculated_mol_wt=50605
     Region          49..135
                     /region_name="RRM1_CELF3_4_5_6"
                     /note="RNA recognition motif 1 (RRM1) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12632"
                     /db_xref="CDD:410041"
     Site            order(55,57,59..60,63,82,84,86,95..97,99,129,131)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410041"
     Region          141..221
                     /region_name="RRM2_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12635"
                     /db_xref="CDD:410043"
     Site            order(143,145,147..148,151,170,172,174,182..184,186,216,
                     218)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410043"
     Region          405..463
                     /region_name="RRM_SF"
                     /note="RNA recognition motif (RRM) superfamily; cl17169"
                     /db_xref="CDD:450164"
     CDS             1..474
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /coded_by="NM_001362329.1:531..1955"
                     /note="isoform 47 is encoded by transcript variant 49"
                     /db_xref="GeneID:108013"
                     /db_xref="MGI:MGI:1932407"
ORIGIN      
        1 myikmatlan gqadnaslst nglgsspgsa ghmnglshsp gnpstipmkd hdaiklfigq
       61 iprnldekdl kplfeefgki yeltvlkdrf tgmhkgcafl tyceresalk aqsalheqkt
      121 lpgmnrpiqv kpadsesrge drklfvgmln kqqseddvrr lfeafgniee ctilrgpdgn
      181 skgcafvkys shaeaqaain alhgsqtmpg assslvvkfa dtdkertmrr mqqmagqmgm
      241 fnpmaipfga ygayaqamqq qaalmasvaq ggylnpmaaf aaaqmqqmaa lnmnglaaap
      301 mtptsggstp pgitapavps ipspigvngf tglppqangq paaeavfang ihpypaqspt
      361 aadplqqaya gvqqyagpay paaygqisqa fpqpppmipq qqregpegcn lliyhlpqef
      421 gdaelmqmfl pfgfvsfdnp asaqtaiqam ngfqigmkrl kvqlkrpkda nrpy
//
LOCUS       NP_001277687            1053 aa            linear   ROD 09-OCT-2023
DEFINITION  toll-like receptor 7 isoform b [Mus musculus].
ACCESSION   NP_001277687 XP_006528775
VERSION     NP_001277687.1
DBSOURCE    REFSEQ: accession NM_001290758.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1053)
  AUTHORS   Huang Y, Liu D, Chen M, Xu S, Peng Q, Zhu Y, Long J, Liu T, Deng Z,
            Xie H, Li J, Liu F and Xiao W.
  TITLE     TLR7 promotes skin inflammation via activating NFkappaB-mTORC1 axis
            in rosacea
  JOURNAL   PeerJ 11, e15976 (2023)
   PUBMED   37780385
  REMARK    GeneRIF: TLR7 promotes skin inflammation via activating
            NFkappaB-mTORC1 axis in rosacea.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1053)
  AUTHORS   Miles MA, Liong S, Liong F, Coward-Smith M, Trollope GS, Oseghale
            O, Erlich JR, Brooks RD, Logan JM, Hickey S, Wang H, Bozinovski S,
            O'Leary JJ, Brooks DA and Selemidis S.
  TITLE     TLR7 promotes chronic airway disease in RSV-infected mice
  JOURNAL   Front Immunol 14, 1240552 (2023)
   PUBMED   37795093
  REMARK    GeneRIF: TLR7 promotes chronic airway disease in RSV-infected mice.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1053)
  AUTHORS   Cosgrove HA, Gingras S, Kim M, Bastacky S, Tilstra JS and Shlomchik
            MJ.
  TITLE     B cell-intrinsic TLR7 expression drives severe lupus in
            TLR9-deficient mice
  JOURNAL   JCI Insight 8 (16), e172219 (2023)
   PUBMED   37606042
  REMARK    GeneRIF: B cell-intrinsic TLR7 expression drives severe lupus in
            TLR9-deficient mice.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1053)
  AUTHORS   Kim J, Ha S, Son M, Kim D, Kim MJ, Kim B, Kim D, Chung HY and Chung
            KW.
  TITLE     TLR7 activation by miR-21 promotes renal fibrosis by activating the
            pro-inflammatory signaling pathway in tubule epithelial cells
  JOURNAL   Cell Commun Signal 21 (1), 215 (2023)
   PUBMED   37596656
  REMARK    GeneRIF: TLR7 activation by miR-21 promotes renal fibrosis by
            activating the pro-inflammatory signaling pathway in tubule
            epithelial cells.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1053)
  AUTHORS   Jackson WD, Giacomassi C, Ward S, Owen A, Luis TC, Spear S,
            Woollard KJ, Johansson C, Strid J and Botto M.
  TITLE     TLR7 activation at epithelial barriers promotes emergency
            myelopoiesis and lung antiviral immunity
  JOURNAL   Elife 12, e85647 (2023)
   PUBMED   37566453
  REMARK    GeneRIF: TLR7 activation at epithelial barriers promotes emergency
            myelopoiesis and lung antiviral immunity.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1053)
  AUTHORS   Heil F, Hemmi H, Hochrein H, Ampenberger F, Kirschning C, Akira S,
            Lipford G, Wagner H and Bauer S.
  TITLE     Species-specific recognition of single-stranded RNA via toll-like
            receptor 7 and 8
  JOURNAL   Science 303 (5663), 1526-1529 (2004)
   PUBMED   14976262
  REMARK    GeneRIF: mediates species-specific recognition of GU-rich
            single-stranded RNA (ssRNA); data suggest that ssRNA represents a
            physiological ligand for TLR7
REFERENCE   7  (residues 1 to 1053)
  AUTHORS   Diebold SS, Kaisho T, Hemmi H, Akira S and Reis e Sousa C.
  TITLE     Innate antiviral responses by means of TLR7-mediated recognition of
            single-stranded RNA
  JOURNAL   Science 303 (5663), 1529-1531 (2004)
   PUBMED   14976261
  REMARK    GeneRIF: results identify ssRNA as a ligand for TLR7 and suggest
            that cells of the innate immune system sense endosomal ssRNA to
            detect infection by RNA viruses
REFERENCE   8  (residues 1 to 1053)
  AUTHORS   Pinhal-Enfield G, Ramanathan M, Hasko G, Vogel SN, Salzman AL,
            Boons GJ and Leibovich SJ.
  TITLE     An angiogenic switch in macrophages involving synergy between
            Toll-like receptors 2, 4, 7, and 9 and adenosine A(2A) receptors
  JOURNAL   Am J Pathol 163 (2), 711-721 (2003)
   PUBMED   12875990
  REMARK    GeneRIF: Results suggest novel signaling pathway in murine
            macrophages involving synergy between toll-like receptors 2, 4, 7,
            and 9 and adenosine A(2A)receptors, that up-regulates VEGF and
            down-regulates TNFalpha expression, thus acting as an angiogenic
            switch.
REFERENCE   9  (residues 1 to 1053)
  AUTHORS   Jurk,M., Heil,F., Vollmer,J., Schetter,C., Krieg,A.M., Wagner,H.,
            Lipford,G. and Bauer,S.
  TITLE     Human TLR7 or TLR8 independently confer responsiveness to the
            antiviral compound R-848
  JOURNAL   Nat Immunol 3 (6), 499 (2002)
   PUBMED   12032557
REFERENCE   10 (residues 1 to 1053)
  AUTHORS   Hemmi H, Kaisho T, Takeuchi O, Sato S, Sanjo H, Hoshino K, Horiuchi
            T, Tomizawa H, Takeda K and Akira S.
  TITLE     Small anti-viral compounds activate immune cells via the TLR7
            MyD88-dependent signaling pathway
  JOURNAL   Nat Immunol 3 (2), 196-200 (2002)
   PUBMED   11812998
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL731735.14, BY204351.1, AJ812652.1, AK036549.1 and BY543663.1.
            
            On Mar 19, 2014 this sequence version replaced XP_006528775.1.
            
            Transcript Variant: This variant (5) lacks an alternate exon in the
            5' region and initiates translation at an alternate upstream start
            codon, compared to variant 1. The encoded isoform (b) has a
            distinct N-terminus and is longer than isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY204351.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1053
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 78.31 cM"
     Protein         1..1053
                     /product="toll-like receptor 7 isoform b"
                     /note="Toll like receptor 7"
                     /calculated_mol_wt=122091
     Region          <35..>246
                     /region_name="PRK15370"
                     /note="type III secretion system effector E3 ubiquitin
                     transferase SlrP"
                     /db_xref="CDD:185268"
     Region          51..72
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          73..93
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          94..131
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          132..155
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          177..>789
                     /region_name="PLN00113"
                     /note="leucine-rich repeat receptor-like protein kinase;
                     Provisional"
                     /db_xref="CDD:215061"
     Region          177..208
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          209..229
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          230..253
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          254..294
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          295..318
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          319..344
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          345..401
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          402..425
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          500..522
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          523..547
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          548..571
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          572..601
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          602..624
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          625..655
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          656..680
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          681..704
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          705..728
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          753..778
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          757..>841
                     /region_name="PCC"
                     /note="polycystin cation channel protein; TIGR00864"
                     /db_xref="CDD:188093"
     Region          894..1039
                     /region_name="TIR"
                     /note="Toll - interleukin 1 - resistance; smart00255"
                     /db_xref="CDD:214587"
     CDS             1..1053
                     /gene="Tlr7"
                     /coded_by="NM_001290758.1:304..3465"
                     /note="isoform b is encoded by transcript variant 5"
                     /db_xref="GeneID:170743"
                     /db_xref="MGI:MGI:2176882"
ORIGIN      
        1 maqwvfsmwt rkrqilifln mllvsrvfgf rwfpktlpce vkvnipeahv ivdctdkhlt
       61 eipegiptnt tnltltinhi psispdsfrr lnhleeidlr cncvpvllgs kanvctkrlq
      121 irpgsfsgls dlkalyldgn qlleipqdlp sslhllslea nnifsitken ltelvnietl
      181 ylgqncyyrn pcnvsysiek daflvmrnlk vlslkdnnvt avpttlppnl lelylynnii
      241 kkiqendfnn lnelqvldls gncprcynvp ypctpcenns plqihdnafn sltelkvlrl
      301 hsnslqhvpp twfknmrnlq eldlsqnyla reieeakflh flpnlveldf sfnyelqvyh
      361 asitlphsls slenlkilrv kgyvfkelkn sslsvlhklp rlevldlgtn fikiadlnif
      421 khfenlklid lsvnkispse esrevgfcpn aqtsvdrhgp qvlealhyfr ydeyarscrf
      481 knkeppsflp lnadchiygq tldlsrnnif fikpsdfqhl sflkclnlsg ntigqtlngs
      541 elwplrelry ldfsnnrldl lystafeelq slevldlssn shyfqaegit hmlnftkklr
      601 lldklmmndn distsasrtm esdslrilef rgnhldvlwr agdnryldff knlfnlevld
      661 isrnslnslp pevfegmppn lknlslakng lksffwdrlq llkhleildl shnqltkvpe
      721 rlancskslt tlilkhnqir qltkyfleda lqlryldiss nkiqviqkts fpenvlnnle
      781 mlvlhhnrfl cncdavwfvw wvnhtdvtip ylatdvtcvg pgahkgqsvi sldlytceld
      841 ltnlilfsvs issvlflmvv mttshlffwd mwyiyyfwka kikgyqhlqs mescydafiv
      901 ydtknsavte wvlqelvakl edprekhfnl cleerdwlpg qpvlenlsqs iqlskktvfv
      961 mtqkyaktes fkmafylshq rlldekvdvi iliflekplq kskflqlrkr lcrssvlewp
     1021 anpqahpyfw qclknalttd nhvaysqmfk etv
//
LOCUS       NP_001239406             254 aa            linear   ROD 09-OCT-2023
DEFINITION  protein arginine N-methyltransferase 1 isoform 3 [Mus musculus].
ACCESSION   NP_001239406
VERSION     NP_001239406.1
DBSOURCE    REFSEQ: accession NM_001252477.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 254)
  AUTHORS   Ye H, Cao L, Jackson-Weaver O, Zheng L and Gou Y.
  TITLE     PRMT1-mediated arginine methylation promotes postnatal calvaria
            bone formation through BMP-Smad signaling
  JOURNAL   Bone 176, 116887 (2023)
   PUBMED   37634683
  REMARK    GeneRIF: PRMT1-mediated arginine methylation promotes postnatal
            calvaria bone formation through BMP-Smad signaling.
REFERENCE   2  (residues 1 to 254)
  AUTHORS   Zhu Y, Wang L, Liu R, Ding X, Yin S, Chen Y, Zhu C, Wang Z and Li
            W.
  TITLE     Inhibition of PRMT1 alleviates sepsis-induced acute kidney injury
            in mice by blocking the TGF-beta1 and IL-6 trans-signaling pathways
  JOURNAL   FEBS Open Bio 13 (10), 1859-1873 (2023)
   PUBMED   37525933
  REMARK    GeneRIF: Inhibition of PRMT1 alleviates sepsis-induced acute kidney
            injury in mice by blocking the TGF-beta1 and IL-6 trans-signaling
            pathways.
REFERENCE   3  (residues 1 to 254)
  AUTHORS   Litzler LC, Zahn A, Dionne KL, Sprumont A, Ferreira SR, Slattery
            MRF, Methot SP, Patenaude AM, Hebert S, Kabir N, Subramani PG, Jung
            S, Richard S, Kleinman CL and Di Noia JM.
  TITLE     Protein arginine methyltransferase 1 regulates B cell fate after
            positive selection in the germinal center in mice
  JOURNAL   J Exp Med 220 (9) (2023)
   PUBMED   37310381
  REMARK    GeneRIF: Protein arginine methyltransferase 1 regulates B cell fate
            after positive selection in the germinal center in mice.
REFERENCE   4  (residues 1 to 254)
  AUTHORS   Li Q, Jiao J, Heng Y, Lu Q, Zheng Y, Li H, Cai J, Mei M and Bao S.
  TITLE     Prmt5 promotes ciliated cell specification of airway epithelial
            progenitors via transcriptional inhibition of Tp63
  JOURNAL   J Biol Chem 299 (8), 104964 (2023)
   PUBMED   37364687
REFERENCE   5  (residues 1 to 254)
  AUTHORS   Liu J, Bu X, Chu C, Dai X, Asara JM, Sicinski P, Freeman GJ and Wei
            W.
  TITLE     PRMT1 mediated methylation of cGAS suppresses anti-tumor immunity
  JOURNAL   Nat Commun 14 (1), 2806 (2023)
   PUBMED   37193698
  REMARK    GeneRIF: PRMT1 mediated methylation of cGAS suppresses anti-tumor
            immunity.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 254)
  AUTHORS   Cimato TR, Tang J, Xu Y, Guarnaccia C, Herschman HR, Pongor S and
            Aletta JM.
  TITLE     Nerve growth factor-mediated increases in protein methylation occur
            predominantly at type I arginine methylation sites and involve
            protein arginine methyltransferase 1
  JOURNAL   J Neurosci Res 67 (4), 435-442 (2002)
   PUBMED   11835310
  REMARK    GeneRIF: Type I protein arginine methyltransferase (PRMT) activity
            produces asymmetric dimethylation of the terminal guanidinonitrogen
            of arginines in substrate proteins, particularly glycine and
            arginine-rich (GAR) segments of proteins
REFERENCE   7  (residues 1 to 254)
  AUTHORS   Pawlak MR, Scherer CA, Chen J, Roshon MJ and Ruley HE.
  TITLE     Arginine N-methyltransferase 1 is required for early
            postimplantation mouse development, but cells deficient in the
            enzyme are viable
  JOURNAL   Mol Cell Biol 20 (13), 4859-4869 (2000)
   PUBMED   10848611
REFERENCE   8  (residues 1 to 254)
  AUTHORS   Brady KP, Rowe LB, Her H, Stevens TJ, Eppig J, Sussman DJ, Sikela J
            and Beier DR.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
REFERENCE   9  (residues 1 to 254)
  AUTHORS   Scherer CA, Chen J, Nachabeh A, Hopkins N and Ruley HE.
  TITLE     Transcriptional specificity of the pluripotent embryonic stem cell
  JOURNAL   Cell Growth Differ 7 (10), 1393-1401 (1996)
   PUBMED   8891343
REFERENCE   10 (residues 1 to 254)
  AUTHORS   Lin WJ, Gary JD, Yang MC, Clarke S and Herschman HR.
  TITLE     The mammalian immediate-early TIS21 protein and the
            leukemia-associated BTG1 protein interact with a protein-arginine
            N-methyltransferase
  JOURNAL   J Biol Chem 271 (25), 15034-15044 (1996)
   PUBMED   8663146
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU524421.1, AK020120.1, W49313.1 and AI846916.1.
            
            Transcript Variant: This variant (3) has multiple differences in
            the coding region, compared to variant 1. The resulting protein
            (isoform 3) is shorter when it is compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK020120.1, SRR10662772.216097.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164141
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..254
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 29.07 cM"
     Protein         1..254
                     /product="protein arginine N-methyltransferase 1 isoform
                     3"
                     /EC_number="2.1.1.319"
                     /note="arginine N-methyltransferase 1; histone-arginine
                     N-methyltransferase PRMT1; heterogeneous nuclear
                     ribonucleoproteins methyltransferase-like 2"
                     /calculated_mol_wt=28778
     Region          <66..>140
                     /region_name="AdoMet_MTases"
                     /note="S-adenosylmethionine-dependent methyltransferases
                     (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes
                     that use S-adenosyl-L-methionine (SAM or AdoMet) as a
                     substrate for methyltransfer, creating the product
                     S-adenosyl-L-homocysteine (AdoHcy); cl17173"
                     /db_xref="CDD:450167"
     Site            order(77..83,100,104,126..128)
                     /site_type="other"
                     /note="S-adenosylmethionine binding site [chemical
                     binding]"
                     /db_xref="CDD:100107"
     CDS             1..254
                     /gene="Prmt1"
                     /gene_synonym="6720434D09Rik; Hrmt1l2; Mrmt1"
                     /coded_by="NM_001252477.1:103..867"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS85293.1"
                     /db_xref="GeneID:15469"
                     /db_xref="MGI:MGI:107846"
ORIGIN      
        1 maaaeaanci mevscgqaes sekpnaedmt skdyyfdsya hfgiheemlk devrtltyrn
       61 smfhnrhlfk dkvvldvgsg tgilcmfaak agarkvigie cssisdyavk ivkankldhv
      121 vtiikgkvee velpvekvdi ytvkvedltf tspfclqvkr ndyvhalvay fnieftrchk
      181 rtgfstspes pythwkqtvf ymedyltvkt geeifgtigm rpnaknnrdl dftidldfkg
      241 qlcelscstd yrmr
//
LOCUS       NP_001394505             440 aa            linear   ROD 09-OCT-2023
DEFINITION  mitogen-activated protein kinase 10 isoform 8 [Mus musculus].
ACCESSION   NP_001394505
VERSION     NP_001394505.1
DBSOURCE    REFSEQ: accession NM_001407576.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 440)
  AUTHORS   Priego M, Noriega L, Kalinin S, Hoffman LM, Feinstein DL and
            Morfini G.
  TITLE     Genetic deletion of c-Jun amino-terminal kinase 3 (JNK3) modestly
            increases disease severity in a mouse model of multiple sclerosis
  JOURNAL   J Neuroimmunol 382, 578152 (2023)
   PUBMED   37454525
  REMARK    GeneRIF: Genetic deletion of c-Jun amino-terminal kinase 3 (JNK3)
            modestly increases disease severity in a mouse model of multiple
            sclerosis.
REFERENCE   2  (residues 1 to 440)
  AUTHORS   Liu F, Deng Y, Zhao Y, Li Z, Gao J, Zhang Y, Yang X, Liu Y and Xia
            Y.
  TITLE     Time series RNA-seq analysis identifies MAPK10 as a critical gene
            in diabetes mellitus-induced atrial fibrillation in mice
  JOURNAL   J Mol Cell Cardiol 168, 70-82 (2022)
   PUBMED   35489387
  REMARK    GeneRIF: Time series RNA-seq analysis identifies MAPK10 as a
            critical gene in diabetes mellitus-induced atrial fibrillation in
            mice.
REFERENCE   3  (residues 1 to 440)
  AUTHORS   Cunningham JG, Scripter JD, Nti SA and Tucker ES.
  TITLE     Early construction of the thalamocortical axon pathway requires
            c-Jun N-terminal kinase signaling within the ventral forebrain
  JOURNAL   Dev Dyn 251 (3), 459-480 (2022)
   PUBMED   34494344
REFERENCE   4  (residues 1 to 440)
  AUTHORS   Goodwani S, Fernandez C, Acton PJ, Buggia-Prevot V, McReynolds ML,
            Ma J, Hu CH, Hamby ME, Jiang Y, Le K, Soth MJ, Jones P and Ray WJ.
  TITLE     Dual Leucine Zipper Kinase Is Constitutively Active in the Adult
            Mouse Brain and Has Both Stress-Induced and Homeostatic Functions
  JOURNAL   Int J Mol Sci 21 (14), 4849 (2020)
   PUBMED   32659913
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 440)
  AUTHORS   Loughran G, Chou MY, Ivanov IP, Jungreis I, Kellis M, Kiran AM,
            Baranov PV and Atkins JF.
  TITLE     Evidence of efficient stop codon readthrough in four mammalian
            genes
  JOURNAL   Nucleic Acids Res 42 (14), 8928-8938 (2014)
   PUBMED   25013167
REFERENCE   6  (residues 1 to 440)
  AUTHORS   Beier H and Grimm M.
  TITLE     Misreading of termination codons in eukaryotes by natural nonsense
            suppressor tRNAs
  JOURNAL   Nucleic Acids Res 29 (23), 4767-4782 (2001)
   PUBMED   11726686
  REMARK    Review article
REFERENCE   7  (residues 1 to 440)
  AUTHORS   Yang DD, Kuan CY, Whitmarsh AJ, Rincon M, Zheng TS, Davis RJ, Rakic
            P and Flavell RA.
  TITLE     Absence of excitotoxicity-induced apoptosis in the hippocampus of
            mice lacking the Jnk3 gene
  JOURNAL   Nature 389 (6653), 865-870 (1997)
   PUBMED   9349820
REFERENCE   8  (residues 1 to 440)
  AUTHORS   Casanova E, Garate C, Ovalle S, Calvo P and Chinchetru MA.
  TITLE     Identification of four splice variants of the mouse
            stress-activated protein kinase JNK/SAPK alpha-isoform
  JOURNAL   Neuroreport 7 (7), 1320-1324 (1996)
   PUBMED   8817558
REFERENCE   9  (residues 1 to 440)
  AUTHORS   Martin JH, Mohit AA and Miller CA.
  TITLE     Developmental expression in the mouse nervous system of the p493F12
            SAP kinase
  JOURNAL   Brain Res Mol Brain Res 35 (1-2), 47-57 (1996)
   PUBMED   8717339
REFERENCE   10 (residues 1 to 440)
  AUTHORS   Suzuki J, Yoshida S, Chen ZL, Momota Y, Kato K, Hirata A and
            Shiosaka S.
  TITLE     Ontogeny of neuropsin mRNA expression in the mouse brain
  JOURNAL   Neurosci Res 23 (4), 345-351 (1995)
   PUBMED   8602273
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC160244.11, AC123664.15,
            AC137121.9 and AC125252.7.
            
            Summary: The protein encoded by this gene is a member of the MAP
            kinase family. MAP kinases act as integration points for multiple
            biochemical signals, and thus are involved in a wide variety of
            cellular processes, such as proliferation, differentiation,
            transcription regulation and development. This kinase is
            specifically expressed in a subset of neurons in the nervous system
            and is activated by threonine and tyrosine phosphorylation.
            Targeted deletion of this gene in mice suggests that it may have a
            role in stress-induced neuronal apoptosis. Alternatively spliced
            transcript variants encoding different isoforms have been found for
            this gene. A recent study provided evidence for translational
            readthrough in this gene, and expression of an additional
            C-terminally extended isoform via the use of an alternative
            in-frame translation termination codon. [provided by RefSeq, Dec
            2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.575432.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..440
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 49.61 cM"
     Protein         1..440
                     /product="mitogen-activated protein kinase 10 isoform 8"
                     /EC_number="2.7.11.24"
                     /note="JNK3 beta1 protein kinase; JNK3 beta2 protein
                     kinase; MAP kinase 10; MAP kinase p49 3F12; c-Jun
                     N-terminal kinase 3; stress-activated protein kinase JNK3;
                     SAPK/Erk/kinase 2"
                     /calculated_mol_wt=49598
     Region          63..374
                     /region_name="STKc_JNK"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     c-Jun N-terminal Kinase; cd07850"
                     /db_xref="CDD:270840"
     Site            order(70..76,78,91,93,110,124,146..152,154..155,189,191,
                     193..194,196,206..207,210,221,223..226,228)
                     /site_type="active"
                     /db_xref="CDD:270840"
     Site            order(70..76,78,91,93,124,146..152,196,206)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270840"
     Site            order(110,154,189,191,210,221,223..226,228)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270840"
     Site            order(150,156,165,168,197..201,337..338,340,343)
                     /site_type="other"
                     /note="KIM docking site [polypeptide binding]"
                     /db_xref="CDD:270840"
     Site            order(206..216,220..228)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270840"
     CDS             1..440
                     /gene="Mapk10"
                     /gene_synonym="C230008H04Rik; JNK3; JNK3B1; JNK3B2;
                     p493F12; p54bSAPK; SAPK(beta); Serk2"
                     /coded_by="NM_001407576.1:517..1839"
                     /note="isoform 8 is encoded by transcript variant 11"
                     /db_xref="GeneID:26414"
                     /db_xref="MGI:MGI:1346863"
ORIGIN      
        1 mslhflyycs eptldvkiaf cqgfdkhvdv ssiakhynms kskvdnqfys vevgdstftv
       61 lkryqnlkpi gsgaqgivca aydavldrnv aikklsrpfq nqthakrayr elvlmkcvnh
      121 kniisllnvf tpqktleefq dvylvmelmd anlcqviqme ldhermsyll yqmlcgikhl
      181 hsagiihrdl kpsnivvksd ctlkildfgl artagtsfmm tpyvvtryyr apevilgmgy
      241 kendidqwnk vieqlgtpcp efmkklqptv rnyvenrpky agltfpklfp dslfpadseh
      301 nklkasqard llskmlvidp akrisvddal qhpyinvwyd paeveapppq iydkqldere
      361 htieewkeli ykevmnseek tkngvvkgqp spsgaavnss eslppsssvn dissmstdqt
      421 lasdtdssle asagplgccr
//
LOCUS       NP_001103610            1044 aa            linear   ROD 09-OCT-2023
DEFINITION  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform b [Mus
            musculus].
ACCESSION   NP_001103610
VERSION     NP_001103610.1
DBSOURCE    REFSEQ: accession NM_001110140.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1044)
  AUTHORS   Iida H, Kono T, Lee CC, Krishnan P, Arvin MC, Weaver SA, Jarvela
            TS, Branco RCS, McLaughlin MR, Bone RN, Tong X, Arvan P, Lindberg I
            and Evans-Molina C.
  TITLE     SERCA2 regulates proinsulin processing and processing enzyme
            maturation in pancreatic beta cells
  JOURNAL   Diabetologia 66 (11), 2042-2061 (2023)
   PUBMED   37537395
  REMARK    GeneRIF: SERCA2 regulates proinsulin processing and processing
            enzyme maturation in pancreatic beta cells.
REFERENCE   2  (residues 1 to 1044)
  AUTHORS   Karatsai O, Lehka L, Wojton D, Grabowska AI, Duda MK, Lenartowski R
            and Redowicz MJ.
  TITLE     Unconventional myosin VI in the heart: Involvement in cardiac
            dysfunction progressing with age
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1869 (6), 166748 (2023)
   PUBMED   37169038
REFERENCE   3  (residues 1 to 1044)
  AUTHORS   Chen HX, Wang XC, Hou HT, Wang J, Yang Q, Chen YL, Chen HZ and He
            GW.
  TITLE     Lysine crotonylation of SERCA2a correlates to cardiac dysfunction
            and arrhythmia in Sirt1 cardiac-specific knockout mice
  JOURNAL   Int J Biol Macromol 242 (Pt 4), 125151 (2023)
   PUBMED   37270127
  REMARK    GeneRIF: Lysine crotonylation of SERCA2a correlates to cardiac
            dysfunction and arrhythmia in Sirt1 cardiac-specific knockout mice.
REFERENCE   4  (residues 1 to 1044)
  AUTHORS   Skogestad J, Albert I, Hougen K, Lothe GB, Lunde M, Eken OS, Veras
            I, Huynh NTT, Borstad M, Marshall S, Shen X, Louch WE, Robinson EL,
            Cleveland JC Jr, Ambardekar AV, Schwisow JA, Jonas E, Calejo AI,
            Morth JP, Tasken K, Melleby AO, Lunde PK, Sjaastad I, Carlson CR
            and Aronsen JM.
  TITLE     Disruption of Phosphodiesterase 3A Binding to SERCA2 Increases
            SERCA2 Activity and Reduces Mortality in Mice With Chronic Heart
            Failure
  JOURNAL   Circulation 147 (16), 1221-1236 (2023)
   PUBMED   36876489
  REMARK    GeneRIF: Disruption of Phosphodiesterase 3A Binding to SERCA2
            Increases SERCA2 Activity and Reduces Mortality in Mice With
            Chronic Heart Failure.
REFERENCE   5  (residues 1 to 1044)
  AUTHORS   Ye B, Zhou H, Chen Y, Luo W, Lin W, Zhao Y, Han J, Han X, Huang W,
            Wu G, Wang X and Liang G.
  TITLE     USP25 Ameliorates Pathological Cardiac Hypertrophy by Stabilizing
            SERCA2a in Cardiomyocytes
  JOURNAL   Circ Res 132 (4), 465-480 (2023)
   PUBMED   36722348
  REMARK    GeneRIF: USP25 Ameliorates Pathological Cardiac Hypertrophy by
            Stabilizing SERCA2a in Cardiomyocytes.
REFERENCE   6  (residues 1 to 1044)
  AUTHORS   Ko MS, Threat TA, Wang X, Horton JH, Cui Y, Wang X, Pryor E, Paris
            J, Wells-Smith J, Kitchen JR, Rowe LB, Eppig J, Satoh T, Brant L,
            Fujiwara H, Yotsumoto S and Nakashima H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
REFERENCE   7  (residues 1 to 1044)
  AUTHORS   Ya J, Erdtsieck-Ernste EB, de Boer PA, van Kempen MJ, Jongsma H,
            Gros D, Moorman AF and Lamers WH.
  TITLE     Heart defects in connexin43-deficient mice
  JOURNAL   Circ Res 82 (3), 360-366 (1998)
   PUBMED   9486664
  REMARK    Review article
REFERENCE   8  (residues 1 to 1044)
  AUTHORS   Harrer JM, Haghighi K, Kim HW, Ferguson DG and Kranias EG.
  TITLE     Coordinate regulation of SR Ca(2+)-ATPase and phospholamban
            expression in developing murine heart
  JOURNAL   Am J Physiol 272 (1 Pt 2), H57-H66 (1997)
   PUBMED   9038922
REFERENCE   9  (residues 1 to 1044)
  AUTHORS   Hawkins C, Xu A and Narayanan N.
  TITLE     Sarcoplasmic reticulum calcium pump in cardiac and slow twitch
            skeletal muscle but not fast twitch skeletal muscle undergoes
            phosphorylation by endogenous and exogenous
            Ca2+/calmodulin-dependent protein kinase. Characterization of
            optimal conditions for calcium pump phosphorylation
  JOURNAL   J Biol Chem 269 (49), 31198-31206 (1994)
   PUBMED   7983062
REFERENCE   10 (residues 1 to 1044)
  AUTHORS   Hsu DK, Donohue PJ, Alberts GF and Winkles JA.
  TITLE     Fibroblast growth factor-1 induces phosphofructokinase, fatty acid
            synthase and Ca(2+)-ATPase mRNA expression in NIH 3T3 cells
  JOURNAL   Biochem Biophys Res Commun 197 (3), 1483-1491 (1993)
   PUBMED   7506544
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ162528.1, AK220538.1, AJ131821.1 and CF742600.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (b), also known as SERCA2B.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ131821.1, AK220538.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1044
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 62.38 cM"
     Protein         1..1044
                     /product="sarcoplasmic/endoplasmic reticulum calcium
                     ATPase 2 isoform b"
                     /EC_number="7.2.2.10"
                     /note="sarcoplasmic/endoplasmic reticulum calcium ATPase
                     2; calcium pump 2; SR Ca(2+)-ATPase 2; endoplasmic
                     reticulum class 1/2 Ca(2+) ATPase; sarco/endoplasmic
                     reticulum Ca2+-ATPase 2"
                     /calculated_mol_wt=114728
     Region          5..988
                     /region_name="P-type_ATPase_SERCA"
                     /note="sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA),
                     similar to mammalian ATP2A1-3/SERCA1-3; cd02083"
                     /db_xref="CDD:319778"
     Site            38
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (O55143.2)"
     Site            49..69
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O55143.2)"
     Site            90..110
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O55143.2)"
     Site            254..273
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O55143.2)"
     Site            296..313
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O55143.2)"
     Site            order(309,795,799)
                     /site_type="other"
                     /note="Ca binding site [ion binding]"
                     /db_xref="CDD:319778"
     Site            order(351..353,442,487,489,492,494,514..516,559,561,
                     624..626,677,683,702,705)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:319778"
     Site            441
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q64578; propagated from
                     UniProtKB/Swiss-Prot (O55143.2)"
     Site            531
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (O55143.2)"
     Region          575..594
                     /region_name="Interaction with HAX1.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (O55143.2)"
     Site            580
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P16615; propagated from
                     UniProtKB/Swiss-Prot (O55143.2)"
     Site            661
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P11507; propagated from
                     UniProtKB/Swiss-Prot (O55143.2)"
     Site            663
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:19144319, ECO:0007744|PubMed:21183079;
                     propagated from UniProtKB/Swiss-Prot (O55143.2)"
     Site            757..776
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O55143.2)"
     Site            order(767,770,798..799,907)
                     /site_type="other"
                     /note="Ca binding site [ion binding]"
                     /db_xref="CDD:319778"
     Region          787..807
                     /region_name="Interaction with PLN.
                     /evidence=ECO:0000250|UniProtKB:P04191"
                     /note="propagated from UniProtKB/Swiss-Prot (O55143.2)"
     Site            787..807
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O55143.2)"
     Region          788..1044
                     /region_name="Interaction with TMEM64 and PDIA3.
                     /evidence=ECO:0000269|PubMed:23395171"
                     /note="propagated from UniProtKB/Swiss-Prot (O55143.2)"
     Site            828..850
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O55143.2)"
     Site            897..916
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O55143.2)"
     Site            930..948
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O55143.2)"
     Region          931..942
                     /region_name="Interaction with PLN.
                     /evidence=ECO:0000250|UniProtKB:P04191"
                     /note="propagated from UniProtKB/Swiss-Prot (O55143.2)"
     Site            964..984
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O55143.2)"
     CDS             1..1044
                     /gene="Atp2a2"
                     /gene_synonym="9530097L16Rik; D5Wsu150e; mKIAA4195;
                     SERCA2; Serca2a; SERCA2B"
                     /coded_by="NM_001110140.3:541..3675"
                     /note="isoform b is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS57378.1"
                     /db_xref="GeneID:11938"
                     /db_xref="MGI:MGI:88110"
ORIGIN      
        1 menahtktve evlghfgvne stglsleqvk klkerwgsne lpaeegktll elvieqfedl
       61 lvrilllaac isfvlawfee geetitafve pfvillilva naivgvwqer naenaiealk
      121 eyepemgkvy rqdrksvqri kakdivpgdi veiavgdkvp adirltsiks ttlrvdqsil
      181 tgesvsvikh tdpvpdprav nqdkknmlfs gtniaagkam gvvvatgvnt eigkirdemv
      241 ateqertplq qkldefgeql skvislicia vwiinighfn dpvhggswir gaiyyfkiav
      301 alavaaipeg lpavittcla lgtrrmakkn aivrslpsve tlgctsvics dktgtlttnq
      361 msvcrmfild kvegdtcsln efsitgstya pigevqkddk pvkchqydgl velaticalc
      421 ndsaldynea kgvyekvgea tetaltclve kmnvfdtelk glskierana cnsvikqlmk
      481 keftlefsrd rksmsvyctp nkpsrtsmsk mfvkgapegv idrcthirvg stkvpmtpgv
      541 kqkimsvire wgsgsdtlrc lalathdnpl kreemhleds anfikyetnl tfvgcvgmld
      601 pprievassv klcrqagirv imitgdnkgt avaicrrigi fgqdedvtsk aftgrefdel
      661 spsaqrdacl narcfarvep shkskivefl qsfdeitamt gdgvndapal kkseigiamg
      721 sgtavaktas emvladdnfs tivaaveegr aiynnmkqfi rylissnvge vvcifltaal
      781 gfpealipvq llwvnlvtdg lpatalgfnp pdldimnkpp rnpkeplisg wlffrylaig
      841 cyvgaatvga aawwfiaadg gprvsfyqls hflqckednp dfdgvdcaif espypmtmal
      901 svlvtiemcn alnslsenqs llrmppweni wlvgsiclsm slhflilyve plplifqitp
      961 lnltqwlmvl kislpvilmd etlkfvarny leqpgkecvq patksscsls actdgiswpf
     1021 vllimplvvw vystdtnfsd mfws
//
LOCUS       NP_001103776             624 aa            linear   ROD 09-OCT-2023
DEFINITION  kelch-like ECH-associated protein 1 [Mus musculus].
ACCESSION   NP_001103776
VERSION     NP_001103776.1
DBSOURCE    REFSEQ: accession NM_001110306.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 624)
  AUTHORS   Li F, Huang H, Zhao P, Jiang J, Ding X, Lu D and Ji L.
  TITLE     Curculigoside mitigates dextran sulfate sodium-induced colitis by
            activation of KEAP1-NRF2 interaction to inhibit oxidative damage
            and autophagy of intestinal epithelium barrier
  JOURNAL   Int J Mol Med 52 (5) (2023)
   PUBMED   37772380
  REMARK    GeneRIF: Curculigoside mitigates dextran sulfate sodium-induced
            colitis by activation of KEAP1-NRF2 interaction to inhibit
            oxidative damage and autophagy of intestinal epithelium barrier.
REFERENCE   2  (residues 1 to 624)
  AUTHORS   Baird L, Taguchi K, Zhang A, Takahashi Y, Suzuki T, Kensler TW and
            Yamamoto M.
  TITLE     A NRF2-induced secretory phenotype activates immune surveillance to
            remove irreparably damaged cells
  JOURNAL   Redox Biol 66, 102845 (2023)
   PUBMED   37597423
REFERENCE   3  (residues 1 to 624)
  AUTHORS   Zhang A, Suzuki T, Adachi S, Yoshida E, Sakaguchi S and Yamamoto M.
  TITLE     Nrf2 activation improves experimental rheumatoid arthritis
  JOURNAL   Free Radic Biol Med 207, 279-295 (2023)
   PUBMED   37494986
  REMARK    GeneRIF: Nrf2 activation improves experimental rheumatoid
            arthritis.
REFERENCE   4  (residues 1 to 624)
  AUTHORS   Ushimoto C, Sugiki S, Kunii K, Inoue S, Kuroda E, Akai R, Iwawaki T
            and Miyazawa K.
  TITLE     Dynamic change and preventive role of stress response via
            Keap1-Nrf2 during renal crystal formation
  JOURNAL   Free Radic Biol Med 207, 120-132 (2023)
   PUBMED   37451369
  REMARK    GeneRIF: Dynamic change and preventive role of stress response via
            Keap1-Nrf2 during renal crystal formation.
REFERENCE   5  (residues 1 to 624)
  AUTHORS   Zhou M, Barkema HW, Gao J, Yang J, Wang Y, Kastelic JP, Khan S, Liu
            G and Han B.
  TITLE     MicroRNA miR-223 modulates NLRP3 and Keap1, mitigating
            lipopolysaccharide-induced inflammation and oxidative stress in
            bovine mammary epithelial cells and murine mammary glands
  JOURNAL   Vet Res 54 (1), 78 (2023)
   PUBMED   37710276
  REMARK    GeneRIF: MicroRNA miR-223 modulates NLRP3 and Keap1, mitigating
            lipopolysaccharide-induced inflammation and oxidative stress in
            bovine mammary epithelial cells and murine mammary glands.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 624)
  AUTHORS   Zipper LM and Mulcahy RT.
  TITLE     The Keap1 BTB/POZ dimerization function is required to sequester
            Nrf2 in cytoplasm
  JOURNAL   J Biol Chem 277 (39), 36544-36552 (2002)
   PUBMED   12145307
REFERENCE   7  (residues 1 to 624)
  AUTHORS   Dinkova-Kostova AT, Holtzclaw WD, Cole RN, Itoh K, Wakabayashi N,
            Katoh Y, Yamamoto M and Talalay P.
  TITLE     Direct evidence that sulfhydryl groups of Keap1 are the sensors
            regulating induction of phase 2 enzymes that protect against
            carcinogens and oxidants
  JOURNAL   Proc Natl Acad Sci U S A 99 (18), 11908-11913 (2002)
   PUBMED   12193649
  REMARK    GeneRIF: evidence that sulfhydryl groups of Keap1 are the sensors
            regulating induction of phase 2 enzymes that protect against
            carcinogens and oxidants
REFERENCE   8  (residues 1 to 624)
  AUTHORS   Kotilinek LA, Bacskai B, Westerman M, Kawarabayashi T, Younkin L,
            Hyman BT, Younkin S and Ashe KH.
  TITLE     Reversible memory loss in a mouse transgenic model of Alzheimer's
            disease
  JOURNAL   J Neurosci 22 (15), 6331-6335 (2002)
   PUBMED   12151510
REFERENCE   9  (residues 1 to 624)
  AUTHORS   Itoh K, Wakabayashi N, Katoh Y, Ishii T, Igarashi K, Engel JD and
            Yamamoto M.
  TITLE     Keap1 represses nuclear activation of antioxidant responsive
            elements by Nrf2 through binding to the amino-terminal Neh2 domain
  JOURNAL   Genes Dev 13 (1), 76-86 (1999)
   PUBMED   9887101
REFERENCE   10 (residues 1 to 624)
  AUTHORS   Chu CC and Paul WE.
  TITLE     Expressed genes in interleukin-4 treated B cells identified by cDNA
            representational difference analysis
  JOURNAL   Mol Immunol 35 (8), 487-502 (1998)
   PUBMED   9798653
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163637.4, CJ179527.1, AK004738.1 and BY586021.1.
            
            Transcript Variant: This variant (3) uses a different splice site
            in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 all
            encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.23849.1,
                                           SRR1660811.104923.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..624
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 7.74 cM"
     Protein         1..624
                     /product="kelch-like ECH-associated protein 1"
                     /note="NRF2 cytosolic inhibitor; cytosolic inhibitor of
                     Nrf2; ring canal protein"
                     /calculated_mol_wt=69422
     Region          56..180
                     /region_name="BTB_POZ_KLHL19_KEAP1"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in Kelch-like
                     ECH-associated protein 1 (KEAP1); cd18248"
                     /db_xref="CDD:349557"
     Region          95..596
                     /region_name="PHA03098"
                     /note="kelch-like protein; Provisional"
                     /db_xref="CDD:222983"
     Site            order(106,109..110,115..117,125..126,157,161..162)
                     /site_type="other"
                     /note="cullin binding site [polypeptide binding]"
                     /db_xref="CDD:349557"
     Site            order(129,131..132,147..148,150..151,154)
                     /site_type="other"
                     /note="modulator binding site [chemical binding]"
                     /db_xref="CDD:349557"
     Site            151
                     /site_type="other"
                     /note="Sensor for electrophilic agents.
                     /evidence=ECO:0000269|PubMed:18268004,
                     ECO:0000269|PubMed:22014577, ECO:0000269|PubMed:26527616;
                     propagated from UniProtKB/Swiss-Prot (Q9Z2X8.1)"
     Site            257
                     /site_type="other"
                     /note="Sensor for electrophilic agents.
                     /evidence=ECO:0000250|UniProtKB:Q14145; propagated from
                     UniProtKB/Swiss-Prot (Q9Z2X8.1)"
     Site            273
                     /site_type="other"
                     /note="Sensor for electrophilic agents.
                     /evidence=ECO:0000269|PubMed:14764894,
                     ECO:0000269|PubMed:26527616; propagated from
                     UniProtKB/Swiss-Prot (Q9Z2X8.1)"
     Site            288
                     /site_type="other"
                     /note="Sensor for electrophilic agents.
                     /evidence=ECO:0000269|PubMed:14764894,
                     ECO:0000269|PubMed:22014577, ECO:0000269|PubMed:26527616;
                     propagated from UniProtKB/Swiss-Prot (Q9Z2X8.1)"
     Region          327..372
                     /region_name="Kelch 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2X8.1)"
     Region          362..409
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          373..423
                     /region_name="Kelch 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2X8.1)"
     Region          413..456
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          424..470
                     /region_name="Kelch 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2X8.1)"
     Site            434
                     /site_type="other"
                     /note="Sensor for electrophilic agents.
                     /evidence=ECO:0000269|PubMed:20498371; propagated from
                     UniProtKB/Swiss-Prot (Q9Z2X8.1)"
     Region          460..503
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          471..517
                     /region_name="Kelch 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2X8.1)"
     Region          507..551
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          519..564
                     /region_name="Kelch 5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2X8.1)"
     Region          554..597
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          565..611
                     /region_name="Kelch 6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2X8.1)"
     CDS             1..624
                     /gene="Keap1"
                     /gene_synonym="INRF2; mKIAA0132"
                     /coded_by="NM_001110306.1:473..2347"
                     /db_xref="CCDS:CCDS22897.1"
                     /db_xref="GeneID:50868"
                     /db_xref="MGI:MGI:1858732"
ORIGIN      
        1 mqpepklsga prssqflplw skcpegagda vmyastecka evtpsqdgnr tfsytledht
       61 kqafgvmnel rlsqqlcdvt lqvkyedipa aqfmahkvvl assspvfkam ftnglreqgm
      121 evvsiegihp kvmerliefa ytasisvgek cvlhvmngav myqidsvvra csdflvqqld
      181 psnaigianf aeqigctelh qrareyiymh fgevakqeef fnlshcqlat lisrddlnvr
      241 cesevfhaci dwvkydcpqr rfyvqallra vrchaltprf lqtqlqkcei lqadarckdy
      301 lvqifqeltl hkptqavpcr apkvgrliyt aggyfrqsls yleaynpsng swlrladlqv
      361 prsglagcvv ggllyavggr nnspdgntds saldcynpmt nqwspcasms vprnrigvgv
      421 idghiyavgg shgcihhssv eryeperdew hlvapmltrr igvgvavlnr llyavggfdg
      481 tnrlnsaecy ypernewrmi tpmntirsga gvcvlhnciy aaggydgqdq lnsverydve
      541 tetwtfvapm rhhrsalgit vhqgkiyvlg gydghtflds vecydpdsdt wsevtrmtsg
      601 rsgvgvavtm epcrkqidqq nctc
//
LOCUS       NP_001371101             303 aa            linear   ROD 09-OCT-2023
DEFINITION  F-box only protein 27 isoform 3 [Mus musculus].
ACCESSION   NP_001371101 XP_006539927
VERSION     NP_001371101.1
DBSOURCE    REFSEQ: accession NM_001384172.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 303)
  AUTHORS   Liu D, Xing R, Zhang Q, Tian X, Qi Y, Song H, Liu Y, Yu H, Zhang X,
            Jing Q, Yan C and Han Y.
  TITLE     The CREG1-FBXO27-LAMP2 axis alleviates diabetic cardiomyopathy by
            promoting autophagy in cardiomyocytes
  JOURNAL   Exp Mol Med 55 (9), 2025-2038 (2023)
   PUBMED   37658156
  REMARK    GeneRIF: The CREG1-FBXO27-LAMP2 axis alleviates diabetic
            cardiomyopathy by promoting autophagy in cardiomyocytes.
REFERENCE   2  (residues 1 to 303)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC109162.12.
            
            On Jun 2, 2020 this sequence version replaced XP_006539927.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.2821506.1,
                                           SRR17784650.806135.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..303
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 16.89 cM"
     Protein         1..303
                     /product="F-box only protein 27 isoform 3"
                     /note="F-box only protein 27"
                     /calculated_mol_wt=33836
     Region          <60..93
                     /region_name="F-box_SF"
                     /note="F-box domain superfamily; cl45894"
                     /db_xref="CDD:459239"
     Region          125..298
                     /region_name="FBA"
                     /note="F-box associated region; pfam04300"
                     /db_xref="CDD:427850"
     CDS             1..303
                     /gene="Fbxo27"
                     /gene_synonym="E130008B10Rik; FBG5; Gm161"
                     /coded_by="NM_001384172.1:23..934"
                     /note="isoform 3 is encoded by transcript variant 4"
                     /db_xref="GeneID:233040"
                     /db_xref="MGI:MGI:2685007"
ORIGIN      
        1 mrssrprrga grgavpakrg agtmgawisr trvptpepdp qevldlsrlp pellllvlsh
       61 vpprtllmhc rrvcrawral vdgqalwlll lardhsaagr alltlarrcl ppahedtpcp
      121 lgqfcalrpl grnlisnpcg qeglrkwmvr hggdgwvvek nrkpvpgaps qtcfvtsfsw
      181 crkkqvvdlv ekglwpelld sggveiavsd wwgarhdsgc kyrlfvtlld ahqnvidkfs
      241 avpdpieqwn ndiylqvthv fsgirrgirf vsfehwgqdt qfwaghygar vtnssviirv
      301 cqs
//
LOCUS       NP_001277684            1050 aa            linear   ROD 09-OCT-2023
DEFINITION  toll-like receptor 7 isoform a precursor [Mus musculus].
ACCESSION   NP_001277684 XP_006528778
VERSION     NP_001277684.1
DBSOURCE    REFSEQ: accession NM_001290755.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1050)
  AUTHORS   Huang Y, Liu D, Chen M, Xu S, Peng Q, Zhu Y, Long J, Liu T, Deng Z,
            Xie H, Li J, Liu F and Xiao W.
  TITLE     TLR7 promotes skin inflammation via activating NFkappaB-mTORC1 axis
            in rosacea
  JOURNAL   PeerJ 11, e15976 (2023)
   PUBMED   37780385
  REMARK    GeneRIF: TLR7 promotes skin inflammation via activating
            NFkappaB-mTORC1 axis in rosacea.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1050)
  AUTHORS   Miles MA, Liong S, Liong F, Coward-Smith M, Trollope GS, Oseghale
            O, Erlich JR, Brooks RD, Logan JM, Hickey S, Wang H, Bozinovski S,
            O'Leary JJ, Brooks DA and Selemidis S.
  TITLE     TLR7 promotes chronic airway disease in RSV-infected mice
  JOURNAL   Front Immunol 14, 1240552 (2023)
   PUBMED   37795093
  REMARK    GeneRIF: TLR7 promotes chronic airway disease in RSV-infected mice.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1050)
  AUTHORS   Cosgrove HA, Gingras S, Kim M, Bastacky S, Tilstra JS and Shlomchik
            MJ.
  TITLE     B cell-intrinsic TLR7 expression drives severe lupus in
            TLR9-deficient mice
  JOURNAL   JCI Insight 8 (16), e172219 (2023)
   PUBMED   37606042
  REMARK    GeneRIF: B cell-intrinsic TLR7 expression drives severe lupus in
            TLR9-deficient mice.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1050)
  AUTHORS   Kim J, Ha S, Son M, Kim D, Kim MJ, Kim B, Kim D, Chung HY and Chung
            KW.
  TITLE     TLR7 activation by miR-21 promotes renal fibrosis by activating the
            pro-inflammatory signaling pathway in tubule epithelial cells
  JOURNAL   Cell Commun Signal 21 (1), 215 (2023)
   PUBMED   37596656
  REMARK    GeneRIF: TLR7 activation by miR-21 promotes renal fibrosis by
            activating the pro-inflammatory signaling pathway in tubule
            epithelial cells.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1050)
  AUTHORS   Jackson WD, Giacomassi C, Ward S, Owen A, Luis TC, Spear S,
            Woollard KJ, Johansson C, Strid J and Botto M.
  TITLE     TLR7 activation at epithelial barriers promotes emergency
            myelopoiesis and lung antiviral immunity
  JOURNAL   Elife 12, e85647 (2023)
   PUBMED   37566453
  REMARK    GeneRIF: TLR7 activation at epithelial barriers promotes emergency
            myelopoiesis and lung antiviral immunity.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1050)
  AUTHORS   Heil F, Hemmi H, Hochrein H, Ampenberger F, Kirschning C, Akira S,
            Lipford G, Wagner H and Bauer S.
  TITLE     Species-specific recognition of single-stranded RNA via toll-like
            receptor 7 and 8
  JOURNAL   Science 303 (5663), 1526-1529 (2004)
   PUBMED   14976262
  REMARK    GeneRIF: mediates species-specific recognition of GU-rich
            single-stranded RNA (ssRNA); data suggest that ssRNA represents a
            physiological ligand for TLR7
REFERENCE   7  (residues 1 to 1050)
  AUTHORS   Diebold SS, Kaisho T, Hemmi H, Akira S and Reis e Sousa C.
  TITLE     Innate antiviral responses by means of TLR7-mediated recognition of
            single-stranded RNA
  JOURNAL   Science 303 (5663), 1529-1531 (2004)
   PUBMED   14976261
  REMARK    GeneRIF: results identify ssRNA as a ligand for TLR7 and suggest
            that cells of the innate immune system sense endosomal ssRNA to
            detect infection by RNA viruses
REFERENCE   8  (residues 1 to 1050)
  AUTHORS   Pinhal-Enfield G, Ramanathan M, Hasko G, Vogel SN, Salzman AL,
            Boons GJ and Leibovich SJ.
  TITLE     An angiogenic switch in macrophages involving synergy between
            Toll-like receptors 2, 4, 7, and 9 and adenosine A(2A) receptors
  JOURNAL   Am J Pathol 163 (2), 711-721 (2003)
   PUBMED   12875990
  REMARK    GeneRIF: Results suggest novel signaling pathway in murine
            macrophages involving synergy between toll-like receptors 2, 4, 7,
            and 9 and adenosine A(2A)receptors, that up-regulates VEGF and
            down-regulates TNFalpha expression, thus acting as an angiogenic
            switch.
REFERENCE   9  (residues 1 to 1050)
  AUTHORS   Jurk,M., Heil,F., Vollmer,J., Schetter,C., Krieg,A.M., Wagner,H.,
            Lipford,G. and Bauer,S.
  TITLE     Human TLR7 or TLR8 independently confer responsiveness to the
            antiviral compound R-848
  JOURNAL   Nat Immunol 3 (6), 499 (2002)
   PUBMED   12032557
REFERENCE   10 (residues 1 to 1050)
  AUTHORS   Hemmi H, Kaisho T, Takeuchi O, Sato S, Sanjo H, Hoshino K, Horiuchi
            T, Tomizawa H, Takeda K and Akira S.
  TITLE     Small anti-viral compounds activate immune cells via the TLR7
            MyD88-dependent signaling pathway
  JOURNAL   Nat Immunol 3 (2), 196-200 (2002)
   PUBMED   11812998
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL731735.14, AK036549.1, AJ812654.1 and BY543663.1.
            
            On Mar 19, 2014 this sequence version replaced XP_006528778.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the shorter isoform (a). Variants 1, 2, 3,
            and 4 encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154906.1, BY218724.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142, SAMN02415133
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1050
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 78.31 cM"
     Protein         1..1050
                     /product="toll-like receptor 7 isoform a precursor"
                     /note="Toll like receptor 7"
                     /calculated_mol_wt=118668
     sig_peptide     1..26
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
                     /calculated_mol_wt=3187
     Region          <32..>243
                     /region_name="PRK15370"
                     /note="type III secretion system effector E3 ubiquitin
                     transferase SlrP"
                     /db_xref="CDD:185268"
     Region          42..64
                     /region_name="LRR 1"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          48..69
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          65..87
                     /region_name="LRR 2"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Site            66
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Site            69
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Region          70..90
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          89..111
                     /region_name="LRR 3"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          91..128
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          126..149
                     /region_name="LRR 4"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          129..152
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          151..170
                     /region_name="LRR 5"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Site            167
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Region          171..195
                     /region_name="LRR 6"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          174..>786
                     /region_name="PLN00113"
                     /note="leucine-rich repeat receptor-like protein kinase;
                     Provisional"
                     /db_xref="CDD:215061"
     Region          174..205
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            190
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Region          203..226
                     /region_name="LRR 7"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          206..226
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            215
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Region          227..250
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          228..247
                     /region_name="LRR 8"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          248..273
                     /region_name="LRR 9"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          251..291
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          275..289
                     /region_name="LRR 10"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          290..312
                     /region_name="LRR 11"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          292..315
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          314..337
                     /region_name="LRR 12"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          316..341
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          339..364
                     /region_name="LRR 13"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          342..398
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          369..392
                     /region_name="LRR 14"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Site            387
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Region          396..419
                     /region_name="LRR 15"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          399..422
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          421..443
                     /region_name="LRR 16"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          493..516
                     /region_name="LRR 17"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          497..519
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          517..542
                     /region_name="LRR 18"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          520..544
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            524
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Site            535
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Region          543..565
                     /region_name="LRR 19"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          545..568
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          567..589
                     /region_name="LRR 20"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          569..598
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            591
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Region          596..619
                     /region_name="LRR 21"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          599..621
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          620..645
                     /region_name="LRR 22"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          622..652
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          650..673
                     /region_name="LRR 23"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          653..677
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          675..698
                     /region_name="LRR 24"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          678..701
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            680
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Region          699..722
                     /region_name="LRR 25"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          702..725
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            721
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Region          724..746
                     /region_name="LRR 26"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          747..770
                     /region_name="LRR 27"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          750..775
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          754..>838
                     /region_name="PCC"
                     /note="polycystin cation channel protein; TIGR00864"
                     /db_xref="CDD:188093"
     Region          773..796
                     /region_name="LRR 28"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Site            800
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Site            838..858
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          891..1036
                     /region_name="TIR"
                     /note="Toll - interleukin 1 - resistance; smart00255"
                     /db_xref="CDD:214587"
     CDS             1..1050
                     /gene="Tlr7"
                     /coded_by="NM_001290755.1:381..3533"
                     /note="isoform a precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS72469.1"
                     /db_xref="GeneID:170743"
                     /db_xref="MGI:MGI:2176882"
ORIGIN      
        1 mvfsmwtrkr qiliflnmll vsrvfgfrwf pktlpcevkv nipeahvivd ctdkhlteip
       61 egiptnttnl tltinhipsi spdsfrrlnh leeidlrcnc vpvllgskan vctkrlqirp
      121 gsfsglsdlk alyldgnqll eipqdlpssl hllsleanni fsitkenlte lvnietlylg
      181 qncyyrnpcn vsysiekdaf lvmrnlkvls lkdnnvtavp ttlppnllel ylynniikki
      241 qendfnnlne lqvldlsgnc prcynvpypc tpcennsplq ihdnafnslt elkvlrlhsn
      301 slqhvpptwf knmrnlqeld lsqnylarei eeakflhflp nlveldfsfn yelqvyhasi
      361 tlphslssle nlkilrvkgy vfkelknssl svlhklprle vldlgtnfik iadlnifkhf
      421 enlklidlsv nkispseesr evgfcpnaqt svdrhgpqvl ealhyfryde yarscrfknk
      481 eppsflplna dchiygqtld lsrnniffik psdfqhlsfl kclnlsgnti gqtlngselw
      541 plrelryldf snnrldllys tafeelqsle vldlssnshy fqaegithml nftkklrlld
      601 klmmndndis tsasrtmesd slrilefrgn hldvlwragd nryldffknl fnlevldisr
      661 nslnslppev fegmppnlkn lslaknglks ffwdrlqllk hleildlshn qltkvperla
      721 ncskslttli lkhnqirqlt kyfledalql ryldissnki qviqktsfpe nvlnnlemlv
      781 lhhnrflcnc davwfvwwvn htdvtipyla tdvtcvgpga hkgqsvisld lytceldltn
      841 lilfsvsiss vlflmvvmtt shlffwdmwy iyyfwkakik gyqhlqsmes cydafivydt
      901 knsavtewvl qelvakledp rekhfnlcle erdwlpgqpv lenlsqsiql skktvfvmtq
      961 kyaktesfkm afylshqrll dekvdviili flekplqksk flqlrkrlcr ssvlewpanp
     1021 qahpyfwqcl knalttdnhv aysqmfketv
//
LOCUS       NP_766277                926 aa            linear   ROD 09-OCT-2023
DEFINITION  antiviral innate immune response receptor RIG-I [Mus musculus].
ACCESSION   NP_766277 XP_990501
VERSION     NP_766277.3
DBSOURCE    REFSEQ: accession NM_172689.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 926)
  AUTHORS   Liu F, Zhuang W, Song B, Yang Y, Liu J, Zheng Y, Liu B, Zheng J,
            Zhao W and Gao C.
  TITLE     MAVS-loaded unanchored Lys63-linked polyubiquitin chains activate
            the RIG-I-MAVS signaling cascade
  JOURNAL   Cell Mol Immunol 20 (10), 1186-1202 (2023)
   PUBMED   37582970
  REMARK    GeneRIF: MAVS-loaded unanchored Lys63-linked polyubiquitin chains
            activate the RIG-I-MAVS signaling cascade.
REFERENCE   2  (residues 1 to 926)
  AUTHORS   Baris A, Fraile-Bethencourt E, Eubanks J, Khou S and Anand S.
  TITLE     Thymidine phosphorylase facilitates retinoic acid inducible gene-I
            induced endothelial dysfunction
  JOURNAL   Cell Death Dis 14 (4), 294 (2023)
   PUBMED   37100811
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 926)
  AUTHORS   Dhillon P, Mulholland KA, Hu H, Park J, Sheng X, Abedini A, Liu H,
            Vassalotti A, Wu J and Susztak K.
  TITLE     Increased levels of endogenous retroviruses trigger
            fibroinflammation and play a role in kidney disease development
  JOURNAL   Nat Commun 14 (1), 559 (2023)
   PUBMED   36732547
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 926)
  AUTHORS   Shi Q, Li G, Dou S, Tang L, Hou C, Wang Z, Gao Y, Gao Z, Hao Y, Mo
            R, Shen B, Wang R, Li Y and Han G.
  TITLE     Negative Regulation of RIG-I by Tim-3 Promotes H1N1 Infection
  JOURNAL   Immunol Invest 52 (1), 1-19 (2023)
   PUBMED   35997714
  REMARK    GeneRIF: Negative Regulation of RIG-I by Tim-3 Promotes H1N1
            Infection.
REFERENCE   5  (residues 1 to 926)
  AUTHORS   Li Z, Zhou Y, Jia K, Yang Y, Zhang L, Wang S, Dong Y, Wang M, Li Y,
            Lu S, Zhang W, Zhang L, Fan Y, Zhang D, Li N, Yu Y, Cao X and Hou
            J.
  TITLE     JMJD4-demethylated RIG-I prevents hepatic steatosis and
            carcinogenesis
  JOURNAL   J Hematol Oncol 15 (1), 161 (2022)
   PUBMED   36333807
  REMARK    GeneRIF: JMJD4-demethylated RIG-I prevents hepatic steatosis and
            carcinogenesis.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 926)
  AUTHORS   Kato H, Takeuchi O, Sato S, Yoneyama M, Yamamoto M, Matsui K,
            Uematsu S, Jung A, Kawai T, Ishii KJ, Yamaguchi O, Otsu K,
            Tsujimura T, Koh CS, Reis e Sousa C, Matsuura Y, Fujita T and Akira
            S.
  TITLE     Differential roles of MDA5 and RIG-I helicases in the recognition
            of RNA viruses
  JOURNAL   Nature 441 (7089), 101-105 (2006)
   PUBMED   16625202
  REMARK    GeneRIF: RIG-I is essential for the production of interferons in
            response to RNA viruses including paramyxoviruses, influenza virus
            and Japanese encephalitis virus, whereas MDA5 is critical for
            picornavirus detection
REFERENCE   7  (residues 1 to 926)
  AUTHORS   Ishii KJ, Coban C, Kato H, Takahashi K, Torii Y, Takeshita F,
            Ludwig H, Sutter G, Suzuki K, Hemmi H, Sato S, Yamamoto M, Uematsu
            S, Kawai T, Takeuchi O and Akira S.
  TITLE     A Toll-like receptor-independent antiviral response induced by
            double-stranded B-form DNA
  JOURNAL   Nat Immunol 7 (1), 40-48 (2006)
   PUBMED   16286919
  REMARK    Erratum:[Nat Immunol. 2006 Apr;7(4):427]
REFERENCE   8  (residues 1 to 926)
  AUTHORS   Rothenfusser S, Goutagny N, DiPerna G, Gong M, Monks BG,
            Schoenemeyer A, Yamamoto M, Akira S and Fitzgerald KA.
  TITLE     The RNA helicase Lgp2 inhibits TLR-independent sensing of viral
            replication by retinoic acid-inducible gene-I
  JOURNAL   J Immunol 175 (8), 5260-5268 (2005)
   PUBMED   16210631
  REMARK    GeneRIF: Lgp2 acts as a negative feedback regulator of antiviral
            signaling by sequestering double-stranded RNA from retinoic
            acid-inducible gene-I (RIG-I).
REFERENCE   9  (residues 1 to 926)
  AUTHORS   Yoneyama M, Kikuchi M, Matsumoto K, Imaizumi T, Miyagishi M, Taira
            K, Foy E, Loo YM, Gale M Jr, Akira S, Yonehara S, Kato A and Fujita
            T.
  TITLE     Shared and unique functions of the DExD/H-box helicases RIG-I,
            MDA5, and LGP2 in antiviral innate immunity
  JOURNAL   J Immunol 175 (5), 2851-2858 (2005)
   PUBMED   16116171
  REMARK    GeneRIF: Shared and unique functions of the DExD/H-box helicases
            RIG-I, MDA5, and LGP2 in antiviral innate immunity.
REFERENCE   10 (residues 1 to 926)
  AUTHORS   Kato H, Sato S, Yoneyama M, Yamamoto M, Uematsu S, Matsui K,
            Tsujimura T, Takeda K, Fujita T, Takeuchi O and Akira S.
  TITLE     Cell type-specific involvement of RIG-I in antiviral response
  JOURNAL   Immunity 23 (1), 19-28 (2005)
   PUBMED   16039576
  REMARK    GeneRIF: RIG-I is essential for induction of type I interferons
            (IFNs) after infection with RNA viruses in fibroblasts and
            conventional dendritic cells (DCs).
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK087261.1, BC127163.1 and AK049305.1.
            
            On Jul 26, 2007 this sequence version replaced NP_766277.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK128929.1, AY553221.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..926
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 20.24 cM"
     Protein         1..926
                     /product="antiviral innate immune response receptor RIG-I"
                     /EC_number="3.6.4.13"
                     /note="probable ATP-dependent RNA helicase DDX58; DEAD/H
                     box helicase 58; DEAD/H box polypeptide RIG-I; retinoic
                     acid-inducible gene-I; RIG-1; retinoic acid-inducible gene
                     1 protein; retinoic acid-inducible gene I protein;
                     RIG-I-like receptor 1; DEAD box protein 58; DEAD
                     (Asp-Glu-Ala-Asp) box polypeptide 58"
                     /calculated_mol_wt=105845
     Region          2..92
                     /region_name="CARD_RIG-I_r1"
                     /note="Caspase activation and recruitment domain found in
                     RIG-I, first repeat; cd08816"
                     /db_xref="CDD:260075"
     Site            order(17..20,23..24,50..51,80..85)
                     /site_type="other"
                     /note="CARD2 interaction site"
                     /db_xref="CDD:260075"
     Region          100..188
                     /region_name="CARD_RIG-I_r2"
                     /note="Caspase activation and recruitment domain found in
                     RIG-I, second repeat; cd08817"
                     /db_xref="CDD:260076"
     Site            order(101,104,132..135,157,161,163..164)
                     /site_type="other"
                     /note="CARD1 interface"
                     /db_xref="CDD:260076"
     Site            order(102,105..106,108..109,111..113,115..116,141,
                     145..147,149..150,153,181,184..185,187)
                     /site_type="other"
                     /note="helical insert domain interface"
                     /db_xref="CDD:260076"
     Region          219..926
                     /region_name="Interaction with ZC3HAV1.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6Q899.2)"
     Region          242..807
                     /region_name="MPH1"
                     /note="ERCC4-related helicase [Replication, recombination
                     and repair]; COG1111"
                     /db_xref="CDD:224036"
     Region          242..443
                     /region_name="DEXHc_RIG-I_DDX58"
                     /note="DEXH-box helicase domain of RIG-I; cd18073"
                     /db_xref="CDD:350831"
     Site            order(242..245,248,266..273,373)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:350831"
     Site            order(299..302,326..327,348,350,354,380..383)
                     /site_type="other"
                     /note="nucleic acid binding site [nucleotide binding]"
                     /db_xref="CDD:350831"
     Region          373..376
                     /region_name="DECH box"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6Q899.2)"
     Region          736..926
                     /region_name="Mediates interaction with RNF135.
                     /evidence=ECO:0000250|UniProtKB:O95786"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6Q899.2)"
     Site            771
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:O95786; propagated from
                     UniProtKB/Swiss-Prot (Q6Q899.2)"
     Region          806..919
                     /region_name="RIG-I_C"
                     /note="C-terminal domain of Retinoic acid-inducible gene
                     (RIG)-I protein, a cytoplasmic viral RNA receptor;
                     cd15805"
                     /db_xref="CDD:276943"
     Site            order(831,854,875..876,887..889,909)
                     /site_type="other"
                     /note="dsRNA binding site [nucleotide binding]"
                     /db_xref="CDD:276943"
     Site            859
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:O95786; propagated from
                     UniProtKB/Swiss-Prot (Q6Q899.2)"
     CDS             1..926
                     /gene="Rigi"
                     /gene_synonym="6430573D20Rik; C330021E21; Ddx58; RIG-I;
                     RLR-1"
                     /coded_by="NM_172689.3:130..2910"
                     /db_xref="CCDS:CCDS18043.1"
                     /db_xref="GeneID:230073"
                     /db_xref="MGI:MGI:2442858"
ORIGIN      
        1 mtaeqrqnlq afrdyikkil dptyilsyms swledeevqy iqaeknnkgp meaaslflqy
       61 llklqsegwf qafldalyha gycglceaie swdfqkiekl eehrlllrrl epefkatvdp
      121 ndilselsec linqeceeir qirdtkgrma gaekmaecli rsdkenwpkv lqlalekdns
      181 kfselwivdk gfkraeskad eddgaeassi qifiqeepec qnlsqnpgpp seassnnlhs
      241 plkprnyqle lalpakkgkn tiicaptgcg ktfvsllice hhlkkfpcgq kgkvvffanq
      301 ipvyeqqatv fsryferlgy niasisgats dsvsvqhiie dndiiiltpq ilvnnlnnga
      361 ipslsvftlm ifdechntsk nhpynqimfr yldhklgesr dplpqvvglt asvgvgdakt
      421 aeeamqhick lcaaldasvi atvrdnvael eqvvykpqki srkvasrtsn tfkciisqlm
      481 keteklakdv seelgklfqi qnrefgtqky eqwivgvhka csvfqmadke eesrvckalf
      541 lytshlrkyn daliisedaq mtdalnylka ffhdvreaaf detereltrr feekleelek
      601 vsrdpsnenp klrdlylvlq eeyhlkpetk tilfvktral vdalkkwiee npalsflkpg
      661 iltgrgrtnr atgmtlpaqk cvleafrasg dnniliatsv adegidiaec nlvilyeyvg
      721 nvikmiqtrg rgrardskcf lltssadvie kekanmikek imnesilrlq twdemkfgkt
      781 vhriqvnekl lrdsqhkpqp vpdkenkkll cgkcknfacy tadirvvets hytvlgdafk
      841 erfvckphpk pkiydnfekk akifcakqnc shdwgifvry ktfeipviki esfvvedivs
      901 gvqnrhskwk dfhferiqfd paemsv
//
LOCUS       NP_001032254             673 aa            linear   ROD 09-OCT-2023
DEFINITION  nuclear factor of activated T-cells, cytoplasmic 2 isoform b [Mus
            musculus].
ACCESSION   NP_001032254
VERSION     NP_001032254.1
DBSOURCE    REFSEQ: accession NM_001037177.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 673)
  AUTHORS   Fu Y, Wang J, Liu C, Liao K, Gao X, Tang R, Fan B, Hong Y, Xiao N,
            Xiao C and Liu WH.
  TITLE     Glycogen synthase kinase 3 controls T-cell exhaustion by regulating
            NFAT activation
  JOURNAL   Cell Mol Immunol 20 (10), 1127-1139 (2023)
   PUBMED   37553428
  REMARK    GeneRIF: Glycogen synthase kinase 3 controls T-cell exhaustion by
            regulating NFAT activation.
REFERENCE   2  (residues 1 to 673)
  AUTHORS   Wan X, Zhao S, Dai Y, Zhang J, Shen Y, Gong L and Le Q.
  TITLE     WNT16b promotes the proliferation and self-renewal of human limbal
            epithelial stem/progenitor cells via activating the
            calcium/calcineurin A/NFATC2 pathway
  JOURNAL   Cell Prolif 56 (10), e13460 (2023)
   PUBMED   36974338
  REMARK    GeneRIF: WNT16b promotes the proliferation and self-renewal of
            human limbal epithelial stem/progenitor cells via activating the
            calcium/calcineurin A/NFATC2 pathway.
REFERENCE   3  (residues 1 to 673)
  AUTHORS   Jiang F, Guo Y, Hu L, Zhang M, Meng J, Si Y and Shi H.
  TITLE     Role of nuclear factor of activated T Cells-1 in Sepsis-induced
            behavioral deficits in mice
  JOURNAL   Brain Res 1806, 148299 (2023)
   PUBMED   36842570
REFERENCE   4  (residues 1 to 673)
  AUTHORS   Nagai J, Lin J and Boyce JA.
  TITLE     Macrophage P2Y6 Receptor Signaling Selectively Activates NFATC2 and
            Suppresses Allergic Lung Inflammation
  JOURNAL   J Immunol 209 (12), 2293-2303 (2022)
   PUBMED   36307120
  REMARK    GeneRIF: Macrophage P2Y6 Receptor Signaling Selectively Activates
            NFATC2 and Suppresses Allergic Lung Inflammation.
REFERENCE   5  (residues 1 to 673)
  AUTHORS   Zhu L, Zhou X, Gu M, Kim J, Li Y, Ko CJ, Xie X, Gao T, Cheng X and
            Sun SC.
  TITLE     Dapl1 controls NFATc2 activation to regulate CD8+ T cell exhaustion
            and responses in chronic infection and cancer
  JOURNAL   Nat Cell Biol 24 (7), 1165-1176 (2022)
   PUBMED   35773432
REFERENCE   6  (residues 1 to 673)
  AUTHORS   Vihma H, Pruunsild P and Timmusk T.
  TITLE     Alternative splicing and expression of human and mouse NFAT genes
  JOURNAL   Genomics 92 (5), 279-291 (2008)
   PUBMED   18675896
REFERENCE   7  (residues 1 to 673)
  AUTHORS   Ho SN, Thomas DJ, Timmerman LA, Li X, Francke U and Crabtree GR.
  TITLE     NFATc3, a lymphoid-specific NFATc family member that is
            calcium-regulated and exhibits distinct DNA binding specificity
  JOURNAL   J Biol Chem 270 (34), 19898-19907 (1995)
   PUBMED   7650004
REFERENCE   8  (residues 1 to 673)
  AUTHORS   Jain J, Burgeon E, Badalian TM, Hogan PG and Rao A.
  TITLE     A similar DNA-binding motif in NFAT family proteins and the Rel
            homology region
  JOURNAL   J Biol Chem 270 (8), 4138-4145 (1995)
   PUBMED   7876165
REFERENCE   9  (residues 1 to 673)
  AUTHORS   Li X, Ho SN, Luna J, Giacalone J, Thomas DJ, Timmerman LA, Crabtree
            GR and Francke U.
  TITLE     Cloning and chromosomal localization of the human and murine genes
            for the T-cell transcription factors NFATc and NFATp
  JOURNAL   Cytogenet Cell Genet 68 (3-4), 185-191 (1995)
   PUBMED   7842733
REFERENCE   10 (residues 1 to 673)
  AUTHORS   Ho AM, Jain J, Rao A and Hogan PG.
  TITLE     Expression of the transcription factor NFATp in a neuronal cell
            line and in the murine nervous system
  JOURNAL   J Biol Chem 269 (45), 28181-28186 (1994)
   PUBMED   7961754
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK135414.1, EU887600.1 and AW049827.1.
            
            Transcript Variant: This variant (2, also known as IB-IIL-VIIa)
            lacks four 3' exons but contains an alternate 3' terminal exon, and
            it thus differs in the 3' coding region and 3' UTR, compared to
            variant 1. The encoded isoform (b) has a distinct C-terminus and is
            shorter than isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU887600.1, AF289078.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..673
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 88.91 cM"
     Protein         1..673
                     /product="nuclear factor of activated T-cells, cytoplasmic
                     2 isoform b"
                     /note="nuclear factor of activated T-cells, cytoplasmic 2;
                     NFAT pre-existing subunit; T-cell transcription factor
                     NFAT1"
                     /calculated_mol_wt=71831
     Region          400..574
                     /region_name="RHD-n_NFAT"
                     /note="N-terminal sub-domain of the Rel homology domain
                     (RHD) of nuclear factor of activated T-cells (NFAT)
                     proteins; cd07881"
                     /db_xref="CDD:143641"
     Site            order(423,426,428..429,431..433,481,522,524..525,539..540,
                     542,573)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143641"
     Region          579..>618
                     /region_name="IPT"
                     /note="Immunoglobulin-like fold, Plexins, Transcription
                     factors (IPT). IPTs are also known as Transcription factor
                     ImmunoGlobin (TIG) domains. They are present in
                     intracellular transcription factors, cell surface
                     receptors (such as plexins and scatter factor...; cl15674"
                     /db_xref="CDD:449574"
     CDS             1..673
                     /gene="Nfatc2"
                     /gene_synonym="NF-ATc2; NF-ATp; NFAT1; NFAT1-D; Nfatp"
                     /coded_by="NM_001037177.2:175..2196"
                     /note="isoform b is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS17113.1"
                     /db_xref="GeneID:18019"
                     /db_xref="MGI:MGI:102463"
ORIGIN      
        1 mdvpepqpdp dggdgpghep ggspqdeldf silfdydyln pieeepiahk aisspsglay
       61 pddvldyglk pcnplaslsg eppgrfgepd sigfqnflsp vkpagasgps prieitpshe
      121 lmqaggalrg rdaglspeqp alalagvaas prftlpvpgy egyreplcls passgssasf
      181 isdtfspyts pcvspnnagp ddlcpqfqni pahysprtsp imsprtslae dsclgrhspv
      241 prpasrsssp gakrrhscae alvaplpaas pqrsrspspq psphvalqdd sipagyppta
      301 gsavlmdaln tlatdspcgi pskiwktspd ptpvstapsk aglarhiypt veflgpceqe
      361 errnsapesi llvpptwpkq lvpaipicsi pvtaslpple wplsnqsgsy elrievqpkp
      421 hhrahyeteg srgavkaptg ghpvvqlhgy menkplglqi figtaderil kphafyqvhr
      481 itgktvttts yekivgntkv leiplepknn mratidcagi lklrnadiel rkgetdigrk
      541 ntrvrlvfrv hvpepsgriv slqaasnpie csqrsahelp mverqdmdsc lvyggqqmil
      601 tgqnftaesk vvfmekttgp agtcetrplp islisadrls pwlsrlqrnp pgsvfrcsvl
      661 lpapgsslvl lal
//
LOCUS       NP_001394503             464 aa            linear   ROD 09-OCT-2023
DEFINITION  mitogen-activated protein kinase 10 isoform 1 [Mus musculus].
ACCESSION   NP_001394503
VERSION     NP_001394503.1
DBSOURCE    REFSEQ: accession NM_001407574.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 464)
  AUTHORS   Priego M, Noriega L, Kalinin S, Hoffman LM, Feinstein DL and
            Morfini G.
  TITLE     Genetic deletion of c-Jun amino-terminal kinase 3 (JNK3) modestly
            increases disease severity in a mouse model of multiple sclerosis
  JOURNAL   J Neuroimmunol 382, 578152 (2023)
   PUBMED   37454525
  REMARK    GeneRIF: Genetic deletion of c-Jun amino-terminal kinase 3 (JNK3)
            modestly increases disease severity in a mouse model of multiple
            sclerosis.
REFERENCE   2  (residues 1 to 464)
  AUTHORS   Liu F, Deng Y, Zhao Y, Li Z, Gao J, Zhang Y, Yang X, Liu Y and Xia
            Y.
  TITLE     Time series RNA-seq analysis identifies MAPK10 as a critical gene
            in diabetes mellitus-induced atrial fibrillation in mice
  JOURNAL   J Mol Cell Cardiol 168, 70-82 (2022)
   PUBMED   35489387
  REMARK    GeneRIF: Time series RNA-seq analysis identifies MAPK10 as a
            critical gene in diabetes mellitus-induced atrial fibrillation in
            mice.
REFERENCE   3  (residues 1 to 464)
  AUTHORS   Cunningham JG, Scripter JD, Nti SA and Tucker ES.
  TITLE     Early construction of the thalamocortical axon pathway requires
            c-Jun N-terminal kinase signaling within the ventral forebrain
  JOURNAL   Dev Dyn 251 (3), 459-480 (2022)
   PUBMED   34494344
REFERENCE   4  (residues 1 to 464)
  AUTHORS   Goodwani S, Fernandez C, Acton PJ, Buggia-Prevot V, McReynolds ML,
            Ma J, Hu CH, Hamby ME, Jiang Y, Le K, Soth MJ, Jones P and Ray WJ.
  TITLE     Dual Leucine Zipper Kinase Is Constitutively Active in the Adult
            Mouse Brain and Has Both Stress-Induced and Homeostatic Functions
  JOURNAL   Int J Mol Sci 21 (14), 4849 (2020)
   PUBMED   32659913
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 464)
  AUTHORS   Loughran G, Chou MY, Ivanov IP, Jungreis I, Kellis M, Kiran AM,
            Baranov PV and Atkins JF.
  TITLE     Evidence of efficient stop codon readthrough in four mammalian
            genes
  JOURNAL   Nucleic Acids Res 42 (14), 8928-8938 (2014)
   PUBMED   25013167
REFERENCE   6  (residues 1 to 464)
  AUTHORS   Beier H and Grimm M.
  TITLE     Misreading of termination codons in eukaryotes by natural nonsense
            suppressor tRNAs
  JOURNAL   Nucleic Acids Res 29 (23), 4767-4782 (2001)
   PUBMED   11726686
  REMARK    Review article
REFERENCE   7  (residues 1 to 464)
  AUTHORS   Yang DD, Kuan CY, Whitmarsh AJ, Rincon M, Zheng TS, Davis RJ, Rakic
            P and Flavell RA.
  TITLE     Absence of excitotoxicity-induced apoptosis in the hippocampus of
            mice lacking the Jnk3 gene
  JOURNAL   Nature 389 (6653), 865-870 (1997)
   PUBMED   9349820
REFERENCE   8  (residues 1 to 464)
  AUTHORS   Casanova E, Garate C, Ovalle S, Calvo P and Chinchetru MA.
  TITLE     Identification of four splice variants of the mouse
            stress-activated protein kinase JNK/SAPK alpha-isoform
  JOURNAL   Neuroreport 7 (7), 1320-1324 (1996)
   PUBMED   8817558
REFERENCE   9  (residues 1 to 464)
  AUTHORS   Martin JH, Mohit AA and Miller CA.
  TITLE     Developmental expression in the mouse nervous system of the p493F12
            SAP kinase
  JOURNAL   Brain Res Mol Brain Res 35 (1-2), 47-57 (1996)
   PUBMED   8717339
REFERENCE   10 (residues 1 to 464)
  AUTHORS   Suzuki J, Yoshida S, Chen ZL, Momota Y, Kato K, Hirata A and
            Shiosaka S.
  TITLE     Ontogeny of neuropsin mRNA expression in the mouse brain
  JOURNAL   Neurosci Res 23 (4), 345-351 (1995)
   PUBMED   8602273
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC160244.11, AC123664.15,
            AC137121.9 and AC125252.7.
            
            Summary: The protein encoded by this gene is a member of the MAP
            kinase family. MAP kinases act as integration points for multiple
            biochemical signals, and thus are involved in a wide variety of
            cellular processes, such as proliferation, differentiation,
            transcription regulation and development. This kinase is
            specifically expressed in a subset of neurons in the nervous system
            and is activated by threonine and tyrosine phosphorylation.
            Targeted deletion of this gene in mice suggests that it may have a
            role in stress-induced neuronal apoptosis. Alternatively spliced
            transcript variants encoding different isoforms have been found for
            this gene. A recent study provided evidence for translational
            readthrough in this gene, and expression of an additional
            C-terminally extended isoform via the use of an alternative
            in-frame translation termination codon. [provided by RefSeq, Dec
            2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784649.398993.1,
                                           SRR14995048.637328.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN01164131,
                                           SAMN01164138 [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..464
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 49.61 cM"
     Protein         1..464
                     /product="mitogen-activated protein kinase 10 isoform 1"
                     /EC_number="2.7.11.24"
                     /note="JNK3 beta1 protein kinase; JNK3 beta2 protein
                     kinase; MAP kinase 10; MAP kinase p49 3F12; c-Jun
                     N-terminal kinase 3; stress-activated protein kinase JNK3;
                     SAPK/Erk/kinase 2"
                     /calculated_mol_wt=52387
     Region          63..398
                     /region_name="STKc_JNK"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     c-Jun N-terminal Kinase; cd07850"
                     /db_xref="CDD:270840"
     Site            order(70..76,78,91,93,110,124,146..152,154..155,189,191,
                     193..194,196,206..207,210,221,223..226,228,265)
                     /site_type="active"
                     /db_xref="CDD:270840"
     Site            order(70..76,78,91,93,124,146..152,196,206)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270840"
     Site            order(110,154,189,191,210,221,223..226,228,265)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270840"
     Site            order(150,156,165,168,197..201,361..362,364,367)
                     /site_type="other"
                     /note="KIM docking site [polypeptide binding]"
                     /db_xref="CDD:270840"
     Site            order(206..216,220..228)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270840"
     Region          221..223
                     /region_name="TXY"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61831.2)"
     Site            221
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by MAP2K7.
                     /evidence=ECO:0000250|UniProtKB:P53779; propagated from
                     UniProtKB/Swiss-Prot (Q61831.2)"
     Site            223
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by MAP2K4.
                     /evidence=ECO:0000250|UniProtKB:P53779; propagated from
                     UniProtKB/Swiss-Prot (Q61831.2)"
     Region          405..464
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61831.2)"
     CDS             1..464
                     /gene="Mapk10"
                     /gene_synonym="C230008H04Rik; JNK3; JNK3B1; JNK3B2;
                     p493F12; p54bSAPK; SAPK(beta); Serk2"
                     /coded_by="NM_001407574.1:514..1908"
                     /note="isoform 1 is encoded by transcript variant 9"
                     /db_xref="GeneID:26414"
                     /db_xref="MGI:MGI:1346863"
ORIGIN      
        1 mslhflyycs eptldvkiaf cqgfdkhvdv ssiakhynms kskvdnqfys vevgdstftv
       61 lkryqnlkpi gsgaqgivca aydavldrnv aikklsrpfq nqthakrayr elvlmkcvnh
      121 kniisllnvf tpqktleefq dvylvmelmd anlcqviqme ldhermsyll yqmlcgikhl
      181 hsagiihrdl kpsnivvksd ctlkildfgl artagtsfmm tpyvvtryyr apevilgmgy
      241 kenvdiwsvg cimgemvrhk ilfpgrdyid qwnkvieqlg tpcpefmkkl qptvrnyven
      301 rpkyagltfp klfpdslfpa dsehnklkas qardllskml vidpakrisv ddalqhpyin
      361 vwydpaevea pppqiydkql derehtieew keliykevmn seektkngvv kgqpspsgaa
      421 vnsseslpps ssvndissms tdqtlasdtd ssleasagpl gccr
//
LOCUS       NP_112544                227 aa            linear   ROD 09-OCT-2023
DEFINITION  triggering receptor expressed on myeloid cells 2 isoform 1
            precursor [Mus musculus].
ACCESSION   NP_112544 NP_067385 NP_112543
VERSION     NP_112544.1
DBSOURCE    REFSEQ: accession NM_031254.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 227)
  AUTHORS   Chen X, Zhao Y, Huang Y, Zhu K, Zeng F, Zhao J, Zhang H, Zhu X,
            Kettenmann H and Xiang X.
  TITLE     TREM2 promotes glioma progression and angiogenesis mediated by
            microglia/brain macrophages
  JOURNAL   Glia 71 (11), 2679-2695 (2023)
   PUBMED   37641212
  REMARK    GeneRIF: TREM2 promotes glioma progression and angiogenesis
            mediated by microglia/brain macrophages.
REFERENCE   2  (residues 1 to 227)
  AUTHORS   Das M, Mao W, Voskobiynyk Y, Necula D, Lew I, Petersen C, Zahn A,
            Yu GQ, Yu X, Smith N, Sayed FA, Gan L, Paz JT and Mucke L.
  TITLE     Alzheimer risk-increasing TREM2 variant causes aberrant cortical
            synapse density and promotes network hyperexcitability in mouse
            models
  JOURNAL   Neurobiol Dis 186, 106263 (2023)
   PUBMED   37591465
  REMARK    GeneRIF: Alzheimer risk-increasing TREM2 variant causes aberrant
            cortical synapse density and promotes network hyperexcitability in
            mouse models.
REFERENCE   3  (residues 1 to 227)
  AUTHORS   Zhong L, Sheng X, Wang W, Li Y, Zhuo R, Wang K, Zhang L, Hu DD,
            Hong Y, Chen L, Rao H, Li T, Chen M, Lin Z, Zhang YW, Wang X, Yan
            XX, Chen X, Bu G and Chen XF.
  TITLE     TREM2 receptor protects against complement-mediated synaptic loss
            by binding to complement C1q during neurodegeneration
  JOURNAL   Immunity 56 (8), 1794-1808 (2023)
   PUBMED   37442133
  REMARK    GeneRIF: TREM2 receptor protects against complement-mediated
            synaptic loss by binding to complement C1q during
            neurodegeneration.
REFERENCE   4  (residues 1 to 227)
  AUTHORS   Yoo Y, Neumayer G, Shibuya Y, Mader MM and Wernig M.
  TITLE     A cell therapy approach to restore microglial Trem2 function in a
            mouse model of Alzheimer's disease
  JOURNAL   Cell Stem Cell 30 (8), 1043-1053 (2023)
   PUBMED   37541210
  REMARK    Erratum:[Cell Stem Cell. 2023 Oct 5;30(10):1392. PMID: 37802040]
REFERENCE   5  (residues 1 to 227)
  AUTHORS   Correale C, Genua M, Vetrano S, Mazzini E, Martinoli C, Spinelli A,
            Arena V, Peyrin-Biroulet L, Caprioli F, Passini N, Panina-Bordignon
            P, Repici A, Malesci A, Rutella S, Rescigno M and Danese S.
  TITLE     Bacterial sensor triggering receptor expressed on myeloid cells-2
            regulates the mucosal inflammatory response
  JOURNAL   Gastroenterology 144 (2), 346-356 (2013)
   PUBMED   23108068
REFERENCE   6  (residues 1 to 227)
  AUTHORS   Daws MR, Sullam PM, Niemi EC, Chen TT, Tchao NK and Seaman WE.
  TITLE     Pattern recognition by TREM-2: binding of anionic ligands
  JOURNAL   J Immunol 171 (2), 594-599 (2003)
   PUBMED   12847223
  REMARK    GeneRIF: TREM-2a and TREM-2b binding to both Gram-positive and
            Gram-negative bacteria is disrupted by anionic bacterial products
            or other anionic carbohydrates and suggests that TREM-2 recognizes
            pathogens via charged carbohydrates expressed on pathogen surface.
REFERENCE   7  (residues 1 to 227)
  AUTHORS   Schmid CD, Sautkulis LN, Danielson PE, Cooper J, Hasel KW, Hilbush
            BS, Sutcliffe JG and Carson MJ.
  TITLE     Heterogeneous expression of the triggering receptor expressed on
            myeloid cells-2 on adult murine microglia
  JOURNAL   J Neurochem 83 (6), 1309-1320 (2002)
   PUBMED   12472885
REFERENCE   8  (residues 1 to 227)
  AUTHORS   Chung DH, Seaman WE and Daws MR.
  TITLE     Characterization of TREM-3, an activating receptor on mouse
            macrophages: definition of a family of single Ig domain receptors
            on mouse chromosome 17
  JOURNAL   Eur J Immunol 32 (1), 59-66 (2002)
   PUBMED   11754004
REFERENCE   9  (residues 1 to 227)
  AUTHORS   Daws MR, Lanier LL, Seaman WE and Ryan JC.
  TITLE     Cloning and characterization of a novel mouse myeloid
            DAP12-associated receptor family
  JOURNAL   Eur J Immunol 31 (3), 783-791 (2001)
   PUBMED   11241283
REFERENCE   10 (residues 1 to 227)
  AUTHORS   Bouchon A, Dietrich J and Colonna M.
  TITLE     Cutting edge: inflammatory responses can be triggered by TREM-1, a
            novel receptor expressed on neutrophils and monocytes
  JOURNAL   J Immunol 164 (10), 4991-4995 (2000)
   PUBMED   10799849
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC166164.2, AK039477.1 and
            BY541740.1.
            
            On or before Jun 13, 2003 this sequence version replaced
            NP_067385.1, NP_112543.1.
            
            Summary: The protein encoded by this gene is part of the
            immunoglobulin and lectin-like superfamily and functions as part of
            the innate immune system. This gene forms part of a cluster of
            genes on mouse chromosome 17 thought to be involved in innate
            immunity. This protein associates with the adaptor protein Dap-12
            and recruits several factors, such as kinases and phospholipase
            C-gamma, to form a receptor signaling complex that activates
            myeloid cells, including dendritic cells and microglia. In humans
            homozygous loss-of-function mutations in this gene cause
            Nasu-Hakola disease and mutations in this gene may be risk factors
            to the development of Alzheimer's disease. In mouse mutations of
            this gene serve as a pathophysiological model for polycystic
            lipomembranous osteodysplasia with sclerosing leukoencephalopathy
            (Nasu-Hakola disease) and for inflammatory bowel disease.
            Alternative splicing results in multiple transcript variants that
            encode different protein isoforms. [provided by RefSeq, Jan 2013].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052784.1, AK039477.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..227
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 23.99 cM"
     Protein         1..227
                     /product="triggering receptor expressed on myeloid cells 2
                     isoform 1 precursor"
                     /note="triggering receptor expressed on myeloid cells 2b;
                     triggering receptor expressed on myeloid cells 2c;
                     triggering receptor expressed on myeloid cells 2a;
                     triggering receptor expressed on monocytes 2"
                     /calculated_mol_wt=22579
     sig_peptide     1..18
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=1966
     mat_peptide     19..227
                     /product="Triggering receptor expressed on myeloid cells
                     2. /id=PRO_0000014988"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99NH8.1)"
                     /calculated_mol_wt=22579
     Site            20
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99NH8.1)"
     Region          21..128
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:448366"
     Region          32..36
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          47..51
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Site            79
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000250|UniProtKB:Q9NZC2; propagated from
                     UniProtKB/Swiss-Prot (Q99NH8.1)"
     Region          93..97
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          107..112
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          123..126
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Site            157..158
                     /site_type="cleavage"
                     /note="Cleavage of ectodomain.
                     /evidence=ECO:0000269|PubMed:28855301; propagated from
                     UniProtKB/Swiss-Prot (Q99NH8.1)"
     Site            172..192
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99NH8.1)"
     CDS             1..227
                     /gene="Trem2"
                     /gene_synonym="TREM-2; Trem2a; Trem2b; Trem2c"
                     /coded_by="NM_031254.3:156..839"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS28865.1"
                     /db_xref="GeneID:83433"
                     /db_xref="MGI:MGI:1913150"
ORIGIN      
        1 mgplhqflll litalsqaln ttvlqgmagq slrvsctyda lkhwgrrkaw crqlgeegpc
       61 qrvvsthgvw llaflkkrng stviaddtla gtvtitlknl qagdaglyqc qslrgreaev
      121 lqkvlvevle dplddqdagd lwvpeesssf egaqvehsts rnqetsfppt sillllacvl
      181 lskflaasil wavargrqkp gtpvvrgldc gqdaghqlqi ltgpggt
//
LOCUS       NP_001372640             470 aa            linear   ROD 09-OCT-2023
DEFINITION  bile acid receptor isoform 4 [Mus musculus].
ACCESSION   NP_001372640 XP_006513456
VERSION     NP_001372640.1
DBSOURCE    REFSEQ: accession NM_001385711.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 470)
  AUTHORS   Xu Z, Huang Z, Zhang Y, Sun H, Hinz U, Heger U, Loos M, Gonzalez
            FJ, Hackert T, Bergmann F and Fortunato F.
  TITLE     Farnesoid X receptor activation inhibits pancreatic carcinogenesis
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1869 (7), 166811 (2023)
   PUBMED   37515840
REFERENCE   2  (residues 1 to 470)
  AUTHORS   Qiu Y, Kang N, Wang X, Yao Y, Cui J, Zhang X and Zheng L.
  TITLE     Loss of Farnesoid X receptor (FXR) accelerates dysregulated glucose
            and renal injury in db/db mice
  JOURNAL   PeerJ 11, e16155 (2023)
   PUBMED   37790634
  REMARK    GeneRIF: Loss of Farnesoid X receptor (FXR) accelerates
            dysregulated glucose and renal injury in db/db mice.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 470)
  AUTHORS   Dean AE, Jungwirth E, Panzitt K, Wagner M and Anakk S.
  TITLE     Hepatic farnesoid X receptor is necessary to facilitate ductular
            reaction and expression of heme biosynthetic genes
  JOURNAL   Hepatol Commun 7 (10), e0213 (2023)
   PUBMED   37695073
  REMARK    GeneRIF: Hepatic farnesoid X receptor is necessary to facilitate
            ductular reaction and expression of heme biosynthetic genes.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 470)
  AUTHORS   Li Z, Dong H, Bian S, Wu H, Song W, Jia X, Chen J, Zhu X, Zhao L,
            Xuan Z, Jin C, Zhou M, Zheng S and Song P.
  TITLE     FXR Maintains the Intestinal Barrier and Stemness by Regulating
            CYP11A1-Mediated Corticosterone Synthesis in Biliary Obstruction
            Diseases
  JOURNAL   Int J Mol Sci 24 (17), 13494 (2023)
   PUBMED   37686300
  REMARK    GeneRIF: FXR Maintains the Intestinal Barrier and Stemness by
            Regulating CYP11A1-Mediated Corticosterone Synthesis in Biliary
            Obstruction Diseases.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 470)
  AUTHORS   Song X, Zhang H, Zhang Y, Goh B, Bao B, Mello SS, Sun X, Zheng W,
            Gazzaniga FS, Wu M, Qu F, Yin Q, Gilmore MS, Oh SF and Kasper DL.
  TITLE     Gut microbial fatty acid isomerization modulates intraepithelial T
            cells
  JOURNAL   Nature 619 (7971), 837-843 (2023)
   PUBMED   37380774
REFERENCE   6  (residues 1 to 470)
  AUTHORS   Shih DQ, Bussen M, Sehayek E, Ananthanarayanan M, Shneider BL,
            Suchy FJ, Shefer S, Bollileni JS, Gonzalez FJ, Breslow JL and
            Stoffel M.
  TITLE     Hepatocyte nuclear factor-1alpha is an essential regulator of bile
            acid and plasma cholesterol metabolism
  JOURNAL   Nat Genet 27 (4), 375-382 (2001)
   PUBMED   11279518
REFERENCE   7  (residues 1 to 470)
  AUTHORS   Lammert F, Carey MC and Paigen B.
  TITLE     Chromosomal organization of candidate genes involved in cholesterol
            gallstone formation: a murine gallstone map
  JOURNAL   Gastroenterology 120 (1), 221-238 (2001)
   PUBMED   11208732
  REMARK    Review article
REFERENCE   8  (residues 1 to 470)
  AUTHORS   Sinal CJ, Tohkin M, Miyata M, Ward JM, Lambert G and Gonzalez FJ.
  TITLE     Targeted disruption of the nuclear receptor FXR/BAR impairs bile
            acid and lipid homeostasis
  JOURNAL   Cell 102 (6), 731-744 (2000)
   PUBMED   11030617
REFERENCE   9  (residues 1 to 470)
  AUTHORS   Kozak CA, Adamson MC and Weinberger C.
  TITLE     Genetic mapping of gene encoding the farnesoid receptor, Fxr, to
            mouse Chromosome 10
  JOURNAL   Mamm Genome 7 (2), 164-165 (1996)
   PUBMED   8835541
REFERENCE   10 (residues 1 to 470)
  AUTHORS   Seol W, Choi HS and Moore DD.
  TITLE     Isolation of proteins that interact specifically with the retinoid
            X receptor: two novel orphan receptors
  JOURNAL   Mol Endocrinol 9 (1), 72-85 (1995)
   PUBMED   7760852
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC152417.3.
            
            On Jul 27, 2020 this sequence version replaced XP_006513456.1.
            
            Transcript Variant: This variant (4), alternatively referred to as
            alpha 2, differs in the 5' UTR and 5' coding region and initiates
            translation at an alternate start codon, compared to variant 1. The
            encoded isoform (4) is shorter and has a distinct N-terminus
            compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189685.193135.1,
                                           SRR5189682.114321.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 44.98 cM"
     Protein         1..470
                     /product="bile acid receptor isoform 4"
                     /note="bile acid receptor; farnesoid X activated receptor;
                     RXR-interacting protein 14; retinoid X
                     receptor-interacting protein 14; farnesol receptor HRR-1"
                     /calculated_mol_wt=53856
     Region          121..204
                     /region_name="NR_DBD_FXR"
                     /note="DNA-binding domain of Farnesoid X receptor (FXR)
                     family is composed of two C4-type zinc fingers; cd06962"
                     /db_xref="CDD:143520"
     Site            order(124,127,141,144,160,166,176,179)
                     /site_type="other"
                     /note="zinc binding site [ion binding]"
                     /db_xref="CDD:143520"
     Site            order(129..130,170..171,174)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:143520"
     Site            order(133..136,142..143,145,147,149..150,173..175,177,180,
                     194)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143520"
     Region          246..465
                     /region_name="NR_LBD_Fxr"
                     /note="The ligand binding domain of Farnesoid X receptor:a
                     member of the nuclear receptor superfamily of
                     ligand-activated transcription factors; cd06936"
                     /db_xref="CDD:132734"
     Site            order(263,282,285..286,288..289,292,326..327,329..330,333,
                     445,459)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:132734"
     Site            order(294,297,301,311..312,315,318..319,462,465)
                     /site_type="other"
                     /note="coactivator recognition site [polypeptide binding]"
                     /db_xref="CDD:132734"
     Site            order(373,392,399,403,426,429..430,433..434,436,439..440,
                     443..444)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:132734"
     CDS             1..470
                     /gene="Nr1h4"
                     /gene_synonym="Fxr; HRR1; RIP14; Rxrip14"
                     /coded_by="NM_001385711.1:270..1682"
                     /note="isoform 4 is encoded by transcript variant 4"
                     /db_xref="GeneID:20186"
                     /db_xref="MGI:MGI:1352464"
ORIGIN      
        1 mnlighshlq atdefslses lfgmltehaa gplgqnldle syspynnvpf pqvqpqisss
       61 syysnlgfyp qqpedwyspg iyelrrmpae tgyqgetevs empvtkkprm aaasagrikg
      121 delcvvcgdr asgyhynalt cegckgffrr sitknavykc knggncvmdm ymrrkcqecr
      181 lrkckemgml aecllteiqc kskrlrknvk qhadqtaned dsegrdlrqv tsttkfcrek
      241 teltadqqtl ldyimdsynk qrmpqeitnk ilkeefsaee nfliltemat shvqilveft
      301 kklpgfqtld hedqiallkg saveamflrs aeifnkklpa ghadlleeri rksgisdeyi
      361 tpmfsfyksv gelkmtqeey alltaivils pdrqyikdre aveklqepll dvlqklckmy
      421 qpenpqhfac llgrltelrt fnhhhaemlm swrvndhkft pllceiwdvq
//
LOCUS       NP_997122               2101 aa            linear   ROD 09-OCT-2023
DEFINITION  general transcription factor 3C polypeptide 1 [Mus musculus].
ACCESSION   NP_997122 XP_133826
VERSION     NP_997122.1
DBSOURCE    REFSEQ: accession NM_207239.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 2101)
  AUTHORS   Sachs P, Bergmaier P, Treutwein K and Mermoud JE.
  TITLE     The Conserved Chromatin Remodeler SMARCAD1 Interacts with TFIIIC
            and Architectural Proteins in Human and Mouse
  JOURNAL   Genes (Basel) 14 (9), 1793 (2023)
   PUBMED   37761933
  REMARK    GeneRIF: The Conserved Chromatin Remodeler SMARCAD1 Interacts with
            TFIIIC and Architectural Proteins in Human and Mouse.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 2101)
  AUTHORS   Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K,
            Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre
            A, Pombero A, Rubenstein JLR, Wakeman WB, Hohmann J, Dee N, Sodt
            AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,
            Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S,
            Wohnoutka P, Hawrylycz MJ, Puelles L and Jones AR.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   3  (residues 1 to 2101)
  AUTHORS   Crepaldi L, Policarpi C, Coatti A, Sherlock WT, Jongbloets BC, Down
            TA and Riccio A.
  TITLE     Binding of TFIIIC to sine elements controls the relocation of
            activity-dependent neuronal genes to transcription factories
  JOURNAL   PLoS Genet 9 (8), e1003699 (2013)
   PUBMED   23966877
REFERENCE   4  (residues 1 to 2101)
  AUTHORS   Wiese CB, Ireland S, Fleming NL, Yu J, Valerius MT, Georgas K, Chiu
            HS, Brennan J, Armstrong J, Little MH, McMahon AP and
            Southard-Smith EM.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 2101)
  AUTHORS   Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S,
            Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N,
            Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y,
            Okado H, Hashimoto M and Asahara H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   6  (residues 1 to 2101)
  AUTHORS   de Planell-Saguer M, Schroeder DG, Rodicio MC, Cox GA and
            Mourelatos Z.
  TITLE     Biochemical and genetic evidence for a role of IGHMBP2 in the
            translational machinery
  JOURNAL   Hum Mol Genet 18 (12), 2115-2126 (2009)
   PUBMED   19299493
REFERENCE   7  (residues 1 to 2101)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (residues 1 to 2101)
  AUTHORS   Meissner W, Thomae R and Seifart KH.
  TITLE     The activity of transcription factor IIIC1 is impaired during
            differentiation of F9 cells
  JOURNAL   J Biol Chem 277 (9), 7148-7156 (2002)
   PUBMED   11741993
  REMARK    GeneRIF: The partial purification of pol III transcription factors
            from PE and EC cells revealed that TFIIIC2 activity could be
            purified from both cell types, whereas TFIIIC1 activity was
            dramatically reduced in extracts from PE cells.
REFERENCE   9  (residues 1 to 2101)
  AUTHORS   Brady KP, Rowe LB, Her H, Stevens TJ, Eppig J, Sussman DJ, Sikela J
            and Beier DR.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC067041.1.
            
            On Aug 30, 2004 this sequence version replaced XP_133826.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC067041.1, AK147325.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2101
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.01 cM"
     Protein         1..2101
                     /product="general transcription factor 3C polypeptide 1"
                     /note="TFIIIC220; TF3C-alpha; TFIIIC 220 kDa subunit;
                     TFIIIC box B-binding subunit; transcription factor IIIC
                     subunit alpha; transcription factor IIIC 220 kDa subunit"
                     /calculated_mol_wt=237346
     Region          174..250
                     /region_name="B-block_TFIIIC"
                     /note="B-block binding subunit of TFIIIC; pfam04182"
                     /db_xref="CDD:367858"
     Region          473..574
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K284.2)"
     Region          588..609
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K284.2)"
     Region          611..707
                     /region_name="Tau138_eWH"
                     /note="extended winged-helix domain of tau138 and related
                     proteins; cd16169"
                     /db_xref="CDD:320085"
     Site            667
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q12789; propagated from
                     UniProtKB/Swiss-Prot (Q8K284.2)"
     Region          718..772
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K284.2)"
     Region          820..864
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K284.2)"
     Site            1063
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q12789; propagated from
                     UniProtKB/Swiss-Prot (Q8K284.2)"
     Region          1186..1239
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K284.2)"
     Site            1196
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8K284.2)"
     Region          1598..1627
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K284.2)"
     Region          1822..1923
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8K284.2)"
     Site            1854
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q12789; propagated from
                     UniProtKB/Swiss-Prot (Q8K284.2)"
     Site            1890
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8K284.2)"
     CDS             1..2101
                     /gene="Gtf3c1"
                     /coded_by="NM_207239.1:12..6317"
                     /db_xref="CCDS:CCDS40122.1"
                     /db_xref="GeneID:233863"
                     /db_xref="MGI:MGI:107887"
ORIGIN      
        1 mdalesllde valegldglc lpalwsrles rspafplple pytqeflwra lathpgisfy
       61 eeprerpdlq lqdryeeidl etgilesrrd pvtledvypi hmilenkdgi qgscryfker
      121 kditssirsk clqprctmve afsrwgkkli ivasqdmryr aliglegdpd lklpdfsyci
      181 lerlgrsrwq gelqrdlhtt afkvdagklh yhrkilnkng litmqshvir lptgaqqhsi
      241 llllnrfhvd rrskydilme klsmmlstrs nqietlgklr eelglcertf krlyqymlna
      301 glakvvslpl qeihpecgpc ktkkgtdvmv rclkllkefk rkmeddhddd ddeeviskgv
      361 ppvdivferd mltqtyelie rrgtkgisqa eirvamnvgk learmlcrll qrfkvvkgfm
      421 edegrqrttk yiscvfaees dlsrqyarek argellttvs lasvqdeslm pegeeaflsd
      481 seseeesscs ggkrrgrgsr gharasgdag sgsrphhstp akggwkvlnl hplkkpkaaa
      541 eersrrssac rdgldtssss elnapfdphs mdshsgdiav ieevrldnpk egggsqkggr
      601 hgssqdkphk tyrllkrrnl iieavtnlrl ieslftiqkm imdqekqegv stkcckksii
      661 rlvrnlseeg llrlyrttvi qdgikkkvdl vvhpsmdqnd plvrsaieqv rfrisnssta
      721 nrvkvppapa pqeeaeeenq epevpsrsan sdpntsskpe strvkktdek mgitplknyk
      781 pvivpglgrs igflpkmprl kamhlflwyl vyghpaghtg eqpalhserk tgkqessrpg
      841 aqpssgddwd tseaknntes sswesemels teivyvdeis wmryvppipi hrdfgfgwal
      901 vsdillclpl sifvqlvqvs ykvdnledfl ndplkkhtli rflprhirqq llykrryifs
      961 vvenlqrlcy mgllqfgpte kfqdkdqvfv flkknavivd tticdphynl ahssrpferr
     1021 lyvldsmqdv ecywfdlqci clntplgvvr cpcaqkicpd pgsdpegslr keqesamdkh
     1081 nlerkcamle yttgsrevvd eglvpgdglg aagldssfya hlkrnwvwts yiinkarknn
     1141 tsengltgrl qtflskrpmp lgsggsgrlp lwsegradae lcadkeeqfe ldreptpgrn
     1201 rkvrggksqk rkrlkkepir ktkrrrrgeh peakskklry qdeadqnalr mmtrlrvsws
     1261 mqedgllmlc riasnvlntk vkgpfvtwqv vrdilhatfe esldktshsv grraryivkn
     1321 pqafmnykvc laevyqdkal vgdfmsrkgn yedpkvcake fkefveklke kfssglrnpn
     1381 leipntlqel fakyrvlaig dekdrvrked elnsvedihf lvlqnliqst lslsnsqsns
     1441 cqsfqifrly refrepvlvr afmecqkrsl vnrrrvshsq gpkknravpf vpmsyqlsqs
     1501 yyklftwrfp ttictesfqf ydrlrtngml dqpdhfsfkd ldssdpsndl vafsldspgg
     1561 hcvtalalfs lgllsvdvri peqivvvdss mvesevmksl gkdgglddde eeedldegsg
     1621 tkrqgvevka hqashtkyll mrgyytvpgm vstrnlnpnd sivvnscqvk frlrntpast
     1681 qlgptgftat pleelqagls clpasftslv dpqlrthcpe efahqmaqsg yspedvaasl
     1741 eilqavaaad cfgidkekls rqfsalekia drrtrtfldy iqdlleqeqv mevggntvrl
     1801 vtmasaqpwl lhsmrlrdme vdtkasgdds qsrlpegpsi edhtsegaav ppvsshstkk
     1861 rphcpetdae eatrlpakkp tlqdvrvaas prpgaeeqae aqapaqlaap edadaggprq
     1921 enqenvgvsg leqlgcefql pegsedprgl tesnmaqaaw esgcervcfv grpwrgvdgh
     1981 lnmpvckgml eavlyhimsr pgvpescllq yyqgvlqpva vlellrgles lgciqkrtlr
     2041 kpasvslfsr pvveglgqas eaealsches tvtfyeptld ctirlgrvfp hdinwnkwih
     2101 l
//
LOCUS       NP_034540                130 aa            linear   ROD 09-OCT-2023
DEFINITION  hypocretin neuropeptide precursor precursor [Mus musculus].
ACCESSION   NP_034540
VERSION     NP_034540.1
DBSOURCE    REFSEQ: accession NM_010410.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 130)
  AUTHORS   Somach RT, Jean ID, Farrugia AM and Cohen AS.
  TITLE     Mild Traumatic Brain Injury Affects Orexin/Hypocretin Physiology
            Differently in Male and Female Mice
  JOURNAL   J Neurotrauma 40 (19-20), 2146-2163 (2023)
   PUBMED   37476962
  REMARK    GeneRIF: Mild Traumatic Brain Injury Affects Orexin/Hypocretin
            Physiology Differently in Male and Female Mice.
REFERENCE   2  (residues 1 to 130)
  AUTHORS   Hung C and Yamanaka A.
  TITLE     The role of orexin neuron activity in sleep/wakefulness regulation
  JOURNAL   Peptides 165, 171007 (2023)
   PUBMED   37030519
  REMARK    GeneRIF: The role of orexin neuron activity in sleep/wakefulness
            regulation.
REFERENCE   3  (residues 1 to 130)
  AUTHORS   Luo F, Deng JY, Sun X, Zhen J and Luo XD.
  TITLE     Anterior cingulate cortex orexin signaling mediates early-life
            stress-induced social impairment in females
  JOURNAL   Proc Natl Acad Sci U S A 120 (20), e2220353120 (2023)
   PUBMED   37155875
  REMARK    GeneRIF: Anterior cingulate cortex orexin signaling mediates
            early-life stress-induced social impairment in females.
REFERENCE   4  (residues 1 to 130)
  AUTHORS   Pintwala SK, Fraigne JJ, Belsham DD and Peever JH.
  TITLE     Immortal orexin cell transplants restore motor-arousal synchrony
            during cataplexy
  JOURNAL   Curr Biol 33 (8), 1550-1564 (2023)
   PUBMED   37044089
REFERENCE   5  (residues 1 to 130)
  AUTHORS   Lu C, Zhang J, Wang B, Gao Q, Ma K, Pei S, Li J and Cui S.
  TITLE     Casein kinase 1alpha is required to maintain murine hypothalamic
            pro-opiomelanocortin expression
  JOURNAL   iScience 26 (5), 106670 (2023)
   PUBMED   37168577
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 130)
  AUTHORS   Chemelli RM, Willie JT, Sinton CM, Elmquist JK, Scammell T, Lee C,
            Richardson JA, Williams SC, Xiong Y, Kisanuki Y, Fitch TE, Nakazato
            M, Hammer RE, Saper CB and Yanagisawa M.
  TITLE     Narcolepsy in orexin knockout mice: molecular genetics of sleep
            regulation
  JOURNAL   Cell 98 (4), 437-451 (1999)
   PUBMED   10481909
REFERENCE   7  (residues 1 to 130)
  AUTHORS   Siegel JM.
  TITLE     Narcolepsy: a key role for hypocretins (orexins)
  JOURNAL   Cell 98 (4), 409-412 (1999)
   PUBMED   10481905
  REMARK    Review article
REFERENCE   8  (residues 1 to 130)
  AUTHORS   Yamamoto Y, Ueta Y, Date Y, Nakazato M, Hara Y, Serino R, Nomura M,
            Shibuya I, Matsukura S and Yamashita H.
  TITLE     Down regulation of the prepro-orexin gene expression in genetically
            obese mice
  JOURNAL   Brain Res Mol Brain Res 65 (1), 14-22 (1999)
   PUBMED   10036303
REFERENCE   9  (residues 1 to 130)
  AUTHORS   Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H,
            Williams SC, Richardson JA, Kozlowski GP, Wilson S, Arch JR,
            Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS,
            Terrett JA, Elshourbagy NA, Bergsma DJ and Yanagisawa M.
  TITLE     Orexins and orexin receptors: a family of hypothalamic
            neuropeptides and G protein-coupled receptors that regulate feeding
            behavior
  JOURNAL   Cell 92 (4), 573-585 (1998)
   PUBMED   9491897
REFERENCE   10 (residues 1 to 130)
  AUTHORS   de Lecea L, Kilduff TS, Peyron C, Gao X, Foye PE, Danielson PE,
            Fukuhara C, Battenberg EL, Gautvik VT, Bartlett FS 2nd, Frankel WN,
            van den Pol AN, Bloom FE, Gautvik KM and Sutcliffe JG.
  TITLE     The hypocretins: hypothalamus-specific peptides with
            neuroexcitatory activity
  JOURNAL   Proc Natl Acad Sci U S A 95 (1), 322-327 (1998)
   PUBMED   9419374
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF019566.1.
            
            Summary: This gene encodes a hypothalamic neuropeptide precursor
            protein that gives rise to two mature neuropeptides, orexin A and
            orexin B, by proteolytic processing. Orexin A and orexin B, which
            bind to orphan G-protein coupled receptors Hcrtr1 and Hcrtr2,
            function in the regulation of sleep and arousal. This neuropeptide
            arrangement may also play a role in feeding behavior, metabolism,
            and homeostasis. [provided by RefSeq, Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF019566.1, CD769124.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..130
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 63.6 cM"
     Protein         1..130
                     /product="hypocretin neuropeptide precursor precursor"
                     /note="prepro-orexin; orexin A; orexin B;
                     preprohypocretin; hypocretin neuropeptide"
                     /calculated_mol_wt=10146
     Region          1..129
                     /region_name="Orexin"
                     /note="Prepro-orexin; pfam02072"
                     /db_xref="CDD:426587"
     sig_peptide     1..32
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=3375
     mat_peptide     33..65
                     /product="Orexin-A. /id=PRO_0000020264"
                     /note="propagated from UniProtKB/Swiss-Prot (O55241.1)"
                     /calculated_mol_wt=3583
     Site            33
                     /site_type="pyrrolidone-carboxylic-acid"
                     /note="Pyrrolidone carboxylic acid.
                     /evidence=ECO:0000250|UniProtKB:O55232; propagated from
                     UniProtKB/Swiss-Prot (O55241.1)"
     Site            65
                     /site_type="amidation"
                     /note="Leucine amide.
                     /evidence=ECO:0000250|UniProtKB:O55232; propagated from
                     UniProtKB/Swiss-Prot (O55241.1)"
     mat_peptide     69..96
                     /product="Orexin-B. /id=PRO_0000020265"
                     /note="propagated from UniProtKB/Swiss-Prot (O55241.1)"
                     /calculated_mol_wt=2937
     Site            96
                     /site_type="amidation"
                     /note="Methionine amide.
                     /evidence=ECO:0000250|UniProtKB:O55232; propagated from
                     UniProtKB/Swiss-Prot (O55241.1)"
     CDS             1..130
                     /gene="Hcrt"
                     /gene_synonym="PPOX"
                     /coded_by="NM_010410.2:91..483"
                     /db_xref="CCDS:CCDS25436.1"
                     /db_xref="GeneID:15171"
                     /db_xref="MGI:MGI:1202306"
ORIGIN      
        1 mnfpstkvpw aavtllllll lppallslgv daqplpdccr qktcscrlye llhgagnhaa
       61 giltlgkrrp gppglqgrlq rllqangnha agiltmgrra gaelephpcs grgcptvttt
      121 alaprggsgv
//
LOCUS       NP_851839                736 aa            linear   ROD 09-OCT-2023
DEFINITION  transcriptional repressor CTCF isoform 1 [Mus musculus].
ACCESSION   NP_851839 NP_031820
VERSION     NP_851839.1
DBSOURCE    REFSEQ: accession NM_181322.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 736)
  AUTHORS   Hewitt SC, Gruzdev A, Willson CJ, Wu SP, Lydon JP, Galjart N and
            DeMayo FJ.
  TITLE     Chromatin architectural factor CTCF is essential for
            progesterone-dependent uterine maturation
  JOURNAL   FASEB J 37 (8), e23103 (2023)
   PUBMED   37489832
  REMARK    GeneRIF: Chromatin architectural factor CTCF is essential for
            progesterone-dependent uterine maturation.
REFERENCE   2  (residues 1 to 736)
  AUTHORS   Smits WK, Vermeulen C, Hagelaar R, Kimura S, Vroegindeweij EM,
            Buijs-Gladdines JGCAM, van de Geer E, Verstegen MJAM, Splinter E,
            van Reijmersdal SV, Buijs A, Galjart N, van Eyndhoven W, van Min M,
            Kuiper R, Kemmeren P, Mullighan CG, de Laat W and Meijerink JPP.
  TITLE     Elevated enhancer-oncogene contacts and higher oncogene expression
            levels by recurrent CTCF inactivating mutations in acute T cell
            leukemia
  JOURNAL   Cell Rep 42 (4), 112373 (2023)
   PUBMED   37060567
REFERENCE   3  (residues 1 to 736)
  AUTHORS   Wang B, Ji L and Bian Q.
  TITLE     SATB1 regulates 3D genome architecture in T cells by constraining
            chromatin interactions surrounding CTCF-binding sites
  JOURNAL   Cell Rep 42 (4), 112323 (2023)
   PUBMED   37000624
  REMARK    GeneRIF: SATB1 regulates 3D genome architecture in T cells by
            constraining chromatin interactions surrounding CTCF-binding sites.
REFERENCE   4  (residues 1 to 736)
  AUTHORS   Marina-Zarate E, Rodriguez-Ronchel A, Gomez MJ, Sanchez-Cabo F and
            Ramiro AR.
  TITLE     Low-affinity CTCF binding drives transcriptional regulation whereas
            high-affinity binding encompasses architectural functions
  JOURNAL   iScience 26 (3), 106106 (2023)
   PUBMED   36852270
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 736)
  AUTHORS   Hsieh TS, Cattoglio C, Slobodyanyuk E, Hansen AS, Darzacq X and
            Tjian R.
  TITLE     Enhancer-promoter interactions and transcription are largely
            maintained upon acute loss of CTCF, cohesin, WAPL or YY1
  JOURNAL   Nat Genet 54 (12), 1919-1932 (2022)
   PUBMED   36471071
  REMARK    GeneRIF: Enhancer-promoter interactions and transcription are
            largely maintained upon acute loss of CTCF, cohesin, WAPL or YY1.
REFERENCE   6  (residues 1 to 736)
  AUTHORS   Farrell CM, West AG and Felsenfeld G.
  TITLE     Conserved CTCF insulator elements flank the mouse and human
            beta-globin loci
  JOURNAL   Mol Cell Biol 22 (11), 3820-3831 (2002)
   PUBMED   11997516
  REMARK    GeneRIF: Conserved CTCF insulator elements flank the mouse and
            human beta-globin loci.
REFERENCE   7  (residues 1 to 736)
  AUTHORS   Burke LJ, Hollemann T, Pieler T and Renkawitz R.
  TITLE     Molecular cloning and expression of the chromatin insulator protein
            CTCF in Xenopus laevis
  JOURNAL   Mech Dev 113 (1), 95-98 (2002)
   PUBMED   11900981
REFERENCE   8  (residues 1 to 736)
  AUTHORS   Chao W, Huynh KD, Spencer RJ, Davidow LS and Lee JT.
  TITLE     CTCF, a candidate trans-acting factor for X-inactivation choice
  JOURNAL   Science 295 (5553), 345-347 (2002)
   PUBMED   11743158
  REMARK    GeneRIF: It's proposed that Tsix and CTCF together establish a
            regulatable epigenetic switch for X-inactivation.
REFERENCE   9  (residues 1 to 736)
  AUTHORS   Lutz M, Burke LJ, Barreto G, Goeman F, Greb H, Arnold R,
            Schultheiss H, Brehm A, Kouzarides T, Lobanenkov V and Renkawitz R.
  TITLE     Transcriptional repression by the insulator protein CTCF involves
            histone deacetylases
  JOURNAL   Nucleic Acids Res 28 (8), 1707-1713 (2000)
   PUBMED   10734189
REFERENCE   10 (residues 1 to 736)
  AUTHORS   Filippova GN, Fagerlie S, Klenova EM, Myers C, Dehner Y, Goodwin G,
            Neiman PE, Collins SJ and Lobanenkov VV.
  TITLE     An exceptionally conserved transcriptional repressor, CTCF, employs
            different combinations of zinc fingers to bind diverged promoter
            sequences of avian and mammalian c-myc oncogenes
  JOURNAL   Mol Cell Biol 16 (6), 2802-2813 (1996)
   PUBMED   8649389
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127419.3 and AC152826.2.
            
            On Jan 18, 2008 this sequence version replaced NP_031820.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049131.1, U51037.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..736
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.04 cM"
     Protein         1..736
                     /product="transcriptional repressor CTCF isoform 1"
                     /note="transcriptional repressor CTCF; CTCFL paralog;
                     11-zinc finger protein"
                     /calculated_mol_wt=83615
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          180..211
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61164.2)"
     Region          266..289
                     /region_name="zf-H2C2_5"
                     /note="C2H2-type zinc-finger domain; pfam13909"
                     /db_xref="CDD:404746"
     Region          268..288
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(273,275,277,279..280,283..284,287,301,303,307..308,
                     311..312,315,329,331,333,335..336,339..340,346)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          280..305
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:433230"
     Site            289
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          296..316
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          309..333
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:433230"
     Site            317
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          324..347
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          351..375
                     /region_name="zf-H2C2_5"
                     /note="C2H2-type zinc-finger domain; pfam13909"
                     /db_xref="CDD:404746"
     Region          353..373
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          <366..500
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Site            374
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          381..401
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            402
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          409..426
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          439..457
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          469..489
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(474,476,478,480..481,484..485,488,502,504,508..509,
                     512..513,516,530,532,534,536..537,540..541,545)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          497..517
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          509..534
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:433230"
     Region          525..546
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          557..573
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          573..686
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61164.2)"
     Site            609
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Site            610
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Site            612
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          699..726
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61164.2)"
     CDS             1..736
                     /gene="Ctcf"
                     /coded_by="NM_181322.4:327..2537"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS22606.1"
                     /db_xref="GeneID:13018"
                     /db_xref="MGI:MGI:109447"
ORIGIN      
        1 megeaveaiv eesetfikgk erktyqrrre ggqeedachl pqnqtdggev vqdvnssvqm
       61 vmmeqldptl lqmktevmeg tvapeaeaav ddtqiitlqv vnmeeqpini gelqlvqvpv
      121 pvtvpvatts veelqgayen evskeglaes epmichtlpl pegfqvvkvg angevetleq
      181 gelppqedss wqkdpdyqpp akktkktkks klryteegkd vdvsvydfee eqqegllsev
      241 naekvvgnmk ppkptkikkk gvkktfqcel csytcprrsn ldrhmkshtd erphkchlcg
      301 rafrtvtllr nhlnthtgtr phkcpdcdma fvtsgelvrh rrykhthekp fkcsmcdyas
      361 vevsklkrhi rshtgerpfq cslcsyasrd tyklkrhmrt hsgekpyecy icharftqsg
      421 tmkmhilqkh tenvakfhcp hcdtviarks dlgvhlrkqh syieqgkkcr ycdavfhery
      481 aliqhqkshk nekrfkcdqc dyacrqerhm imhkrthtge kpyacshcdk tfrqkqlldm
      541 hfkryhdpnf vpaafvcskc gktftrrntm arhadncagp dgvegengge tkkskrgrkr
      601 kmrskkedss dseenaepdl ddneeeeepa veiepepepq pqpppppqpv apapppakkr
      661 rgrppgrtnq pkqnqptaii qvedqntgai eniivevkke pdaepaegee eeaqaattda
      721 pngdltpemi lsmmdr
//
LOCUS       NP_001278097             907 aa            linear   ROD 09-OCT-2023
DEFINITION  nuclear factor of activated T-cells, cytoplasmic 2 isoform e [Mus
            musculus].
ACCESSION   NP_001278097 XP_006498952
VERSION     NP_001278097.1
DBSOURCE    REFSEQ: accession NM_001291168.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 907)
  AUTHORS   Fu Y, Wang J, Liu C, Liao K, Gao X, Tang R, Fan B, Hong Y, Xiao N,
            Xiao C and Liu WH.
  TITLE     Glycogen synthase kinase 3 controls T-cell exhaustion by regulating
            NFAT activation
  JOURNAL   Cell Mol Immunol 20 (10), 1127-1139 (2023)
   PUBMED   37553428
  REMARK    GeneRIF: Glycogen synthase kinase 3 controls T-cell exhaustion by
            regulating NFAT activation.
REFERENCE   2  (residues 1 to 907)
  AUTHORS   Wan X, Zhao S, Dai Y, Zhang J, Shen Y, Gong L and Le Q.
  TITLE     WNT16b promotes the proliferation and self-renewal of human limbal
            epithelial stem/progenitor cells via activating the
            calcium/calcineurin A/NFATC2 pathway
  JOURNAL   Cell Prolif 56 (10), e13460 (2023)
   PUBMED   36974338
  REMARK    GeneRIF: WNT16b promotes the proliferation and self-renewal of
            human limbal epithelial stem/progenitor cells via activating the
            calcium/calcineurin A/NFATC2 pathway.
REFERENCE   3  (residues 1 to 907)
  AUTHORS   Jiang F, Guo Y, Hu L, Zhang M, Meng J, Si Y and Shi H.
  TITLE     Role of nuclear factor of activated T Cells-1 in Sepsis-induced
            behavioral deficits in mice
  JOURNAL   Brain Res 1806, 148299 (2023)
   PUBMED   36842570
REFERENCE   4  (residues 1 to 907)
  AUTHORS   Nagai J, Lin J and Boyce JA.
  TITLE     Macrophage P2Y6 Receptor Signaling Selectively Activates NFATC2 and
            Suppresses Allergic Lung Inflammation
  JOURNAL   J Immunol 209 (12), 2293-2303 (2022)
   PUBMED   36307120
  REMARK    GeneRIF: Macrophage P2Y6 Receptor Signaling Selectively Activates
            NFATC2 and Suppresses Allergic Lung Inflammation.
REFERENCE   5  (residues 1 to 907)
  AUTHORS   Zhu L, Zhou X, Gu M, Kim J, Li Y, Ko CJ, Xie X, Gao T, Cheng X and
            Sun SC.
  TITLE     Dapl1 controls NFATc2 activation to regulate CD8+ T cell exhaustion
            and responses in chronic infection and cancer
  JOURNAL   Nat Cell Biol 24 (7), 1165-1176 (2022)
   PUBMED   35773432
REFERENCE   6  (residues 1 to 907)
  AUTHORS   Vihma H, Pruunsild P and Timmusk T.
  TITLE     Alternative splicing and expression of human and mouse NFAT genes
  JOURNAL   Genomics 92 (5), 279-291 (2008)
   PUBMED   18675896
REFERENCE   7  (residues 1 to 907)
  AUTHORS   Ho SN, Thomas DJ, Timmerman LA, Li X, Francke U and Crabtree GR.
  TITLE     NFATc3, a lymphoid-specific NFATc family member that is
            calcium-regulated and exhibits distinct DNA binding specificity
  JOURNAL   J Biol Chem 270 (34), 19898-19907 (1995)
   PUBMED   7650004
REFERENCE   8  (residues 1 to 907)
  AUTHORS   Jain J, Burgeon E, Badalian TM, Hogan PG and Rao A.
  TITLE     A similar DNA-binding motif in NFAT family proteins and the Rel
            homology region
  JOURNAL   J Biol Chem 270 (8), 4138-4145 (1995)
   PUBMED   7876165
REFERENCE   9  (residues 1 to 907)
  AUTHORS   Li X, Ho SN, Luna J, Giacalone J, Thomas DJ, Timmerman LA, Crabtree
            GR and Francke U.
  TITLE     Cloning and chromosomal localization of the human and murine genes
            for the T-cell transcription factors NFATc and NFATp
  JOURNAL   Cytogenet Cell Genet 68 (3-4), 185-191 (1995)
   PUBMED   7842733
REFERENCE   10 (residues 1 to 907)
  AUTHORS   Ho AM, Jain J, Rao A and Hogan PG.
  TITLE     Expression of the transcription factor NFATp in a neuronal cell
            line and in the murine nervous system
  JOURNAL   J Biol Chem 269 (45), 28181-28186 (1994)
   PUBMED   7961754
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK044489.1, EU887587.1, EU887585.1 and BP757417.1.
            
            On Mar 27, 2014 this sequence version replaced XP_006498952.1.
            
            Transcript Variant: This variant (5, also known as IA-IIL-deltaXa)
            contains an alternate 5' terminal exon, and it thus differs in the
            5' UTR and 5' coding region, compared to variant 1. The encoded
            isoform (e) has a distinct N-terminus and is shorter than isoform
            a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU887587.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..907
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 88.91 cM"
     Protein         1..907
                     /product="nuclear factor of activated T-cells, cytoplasmic
                     2 isoform e"
                     /note="nuclear factor of activated T-cells, cytoplasmic 2;
                     NFAT pre-existing subunit; T-cell transcription factor
                     NFAT1"
                     /calculated_mol_wt=97864
     Region          380..554
                     /region_name="RHD-n_NFAT"
                     /note="N-terminal sub-domain of the Rel homology domain
                     (RHD) of nuclear factor of activated T-cells (NFAT)
                     proteins; cd07881"
                     /db_xref="CDD:143641"
     Site            order(403,406,408..409,411..413,461,502,504..505,519..520,
                     522,553)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143641"
     Region          559..659
                     /region_name="IPT_NFAT"
                     /note="IPT domain of the NFAT family of transcription
                     factors. NFAT transcription complexes are a target of
                     calcineurin, a calcium dependent phosphatase, and activate
                     genes mainly involved in cell-cell-interaction; cd01178"
                     /db_xref="CDD:238583"
     Site            order(583,647)
                     /site_type="DNA binding"
                     /note="DNA binding sites [nucleotide binding]"
                     /db_xref="CDD:238583"
     CDS             1..907
                     /gene="Nfatc2"
                     /gene_synonym="NF-ATc2; NF-ATp; NFAT1; NFAT1-D; Nfatp"
                     /coded_by="NM_001291168.1:120..2843"
                     /note="isoform e is encoded by transcript variant 5"
                     /db_xref="GeneID:18019"
                     /db_xref="MGI:MGI:102463"
ORIGIN      
        1 mqrpalrrpg prqplrtmgs adreepiahk aisspsglay pddvldyglk pcnplaslsg
       61 eppgrfgepd sigfqnflsp vkpagasgps prieitpshe lmqaggalrg rdaglspeqp
      121 alalagvaas prftlpvpgy egyreplcls passgssasf isdtfspyts pcvspnnagp
      181 ddlcpqfqni pahysprtsp imsprtslae dsclgrhspv prpasrsssp gakrrhscae
      241 alvaplpaas pqrsrspspq psphvalqdd sipagyppta gsavlmdaln tlatdspcgi
      301 pskiwktspd ptpvstapsk aglarhiypt veflgpceqe errnsapesi llvpptwpkq
      361 lvpaipicsi pvtaslpple wplsnqsgsy elrievqpkp hhrahyeteg srgavkaptg
      421 ghpvvqlhgy menkplglqi figtaderil kphafyqvhr itgktvttts yekivgntkv
      481 leiplepknn mratidcagi lklrnadiel rkgetdigrk ntrvrlvfrv hvpepsgriv
      541 slqaasnpie csqrsahelp mverqdmdsc lvyggqqmil tgqnftaesk vvfmekttdg
      601 qqiwemeatv dkdksqpnml fveipeyrnk hirvpvkvnf yvingkrkrs qpqhftyhpv
      661 paiktepsde yepslicspa hgglgsqpyy pqhpmlaesp sclvatmapc qqfrsglssp
      721 daryqqqspa aalyqrsksl spgllgyqqp sllaaplgla dahrsvlvha gsqgqgqgst
      781 lphtssasqq aspvihyspt nqqlrggghq efqhimycen fgpssarpgp ppinqgqrls
      841 pgayptviqq qtapsqraak ngpsdqkeal ptgvtvkqeq nldqtylddv neiirkefsg
      901 ppsrnqt
//
LOCUS       NP_001165676             590 aa            linear   ROD 09-OCT-2023
DEFINITION  AT-rich interactive domain-containing protein 5A isoform 1 [Mus
            musculus].
ACCESSION   NP_001165676
VERSION     NP_001165676.1
DBSOURCE    REFSEQ: accession NM_001172205.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 590)
  AUTHORS   Li X, Hua S, Fang D, Fei X, Tan Z, Zheng F, Wang W and Fang M.
  TITLE     RAGE deficiency ameliorates autoimmune hepatitis involving
            inhibition of IL-6 production via suppressing protein Arid5a in
            mice
  JOURNAL   Clin Exp Med 23 (6), 2167-2179 (2023)
   PUBMED   36454447
  REMARK    GeneRIF: RAGE deficiency ameliorates autoimmune hepatitis involving
            inhibition of IL-6 production via suppressing protein Arid5a in
            mice.
REFERENCE   2  (residues 1 to 590)
  AUTHORS   Taylor TC, Li Y, Li DD, Majumder S, McGeachy MJ, Biswas PS, Gingras
            S and Gaffen SL.
  TITLE     Arid5a Mediates an IL-17-Dependent Pathway That Drives Autoimmunity
            but Not Antifungal Host Defense
  JOURNAL   J Immunol 209 (6), 1138-1145 (2022)
   PUBMED   35940634
  REMARK    GeneRIF: Arid5a Mediates an IL-17-Dependent Pathway That Drives
            Autoimmunity but Not Antifungal Host Defense.
REFERENCE   3  (residues 1 to 590)
  AUTHORS   Catela C, Chen Y, Weng Y, Wen K and Kratsios P.
  TITLE     Control of spinal motor neuron terminal differentiation through
            sustained Hoxc8 gene activity
  JOURNAL   Elife 11, e70766 (2022)
   PUBMED   35315772
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 590)
  AUTHORS   Nyati KK, Hashimoto S, Singh SK, Tekguc M, Metwally H, Liu YC,
            Okuzaki D, Gemechu Y, Kang S and Kishimoto T.
  TITLE     The novel long noncoding RNA AU021063, induced by IL-6/Arid5a
            signaling, exacerbates breast cancer invasion and metastasis by
            stabilizing Trib3 and activating the Mek/Erk pathway
  JOURNAL   Cancer Lett 520, 295-306 (2021)
   PUBMED   34389433
  REMARK    GeneRIF: The novel long noncoding RNA AU021063, induced by
            IL-6/Arid5a signaling, exacerbates breast cancer invasion and
            metastasis by stabilizing Trib3 and activating the Mek/Erk pathway.
REFERENCE   5  (residues 1 to 590)
  AUTHORS   Chalise JP, Hashimoto S, Parajuli G, Kang S, Singh SK, Gemechu Y,
            Metwally H, Nyati KK, Dubey PK, Zaman MM, Nagahama Y, Hamza H,
            Masuda K and Kishimoto T.
  TITLE     Feedback regulation of Arid5a and Ppar-gamma2 maintains adipose
            tissue homeostasis
  JOURNAL   Proc Natl Acad Sci U S A 116 (30), 15128-15133 (2019)
   PUBMED   31289228
  REMARK    GeneRIF: Feedback regulation of Arid5a and Ppar-gamma2 maintains
            adipose tissue homeostasis.
REFERENCE   6  (residues 1 to 590)
  AUTHORS   Zaman MM, Masuda K, Nyati KK, Dubey PK, Ripley B, Wang K, Chalise
            JP, Higa M, Hanieh H and Kishimoto T.
  TITLE     Arid5a exacerbates IFN-gamma-mediated septic shock by stabilizing
            T-bet mRNA
  JOURNAL   Proc Natl Acad Sci U S A 113 (41), 11543-11548 (2016)
   PUBMED   27671645
  REMARK    GeneRIF: Arid5a deficiency resulted in decreased levels of
            IFN-gamma under Th1 cell conditions, in which T-box expressed in T
            cells (T-bet) mRNA expression was inhibited.
REFERENCE   7  (residues 1 to 590)
  AUTHORS   Masuda K, Ripley B, Nyati KK, Dubey PK, Zaman MM, Hanieh H, Higa M,
            Yamashita K, Standley DM, Mashima T, Katahira M, Okamoto T,
            Matsuura Y, Takeuchi O and Kishimoto T.
  TITLE     Arid5a regulates naive CD4+ T cell fate through selective
            stabilization of Stat3 mRNA
  JOURNAL   J Exp Med 213 (4), 605-619 (2016)
   PUBMED   27022145
  REMARK    GeneRIF: T cell-intrinsic role of Arid5a on fate decisions of naive
            CD4(+)T cells through selective stabilization of Stat3 mRNA.
REFERENCE   8  (residues 1 to 590)
  AUTHORS   Masuda K, Ripley B, Nishimura R, Mino T, Takeuchi O, Shioi G,
            Kiyonari H and Kishimoto T.
  TITLE     Arid5a controls IL-6 mRNA stability, which contributes to elevation
            of IL-6 level in vivo
  JOURNAL   Proc Natl Acad Sci U S A 110 (23), 9409-9414 (2013)
   PUBMED   23676272
  REMARK    GeneRIF: Arid5a controls IL-6 mRNA stability, which contributes to
            elevation of IL-6 level in vivo.
REFERENCE   9  (residues 1 to 590)
  AUTHORS   Amano K, Hata K, Muramatsu S, Wakabayashi M, Takigawa Y, Ono K,
            Nakanishi M, Takashima R, Kogo M, Matsuda A, Nishimura R and Yoneda
            T.
  TITLE     Arid5a cooperates with Sox9 to stimulate chondrocyte-specific
            transcription
  JOURNAL   Mol Biol Cell 22 (8), 1300-1311 (2011)
   PUBMED   21346191
  REMARK    GeneRIF: AT-rich interactive domain-containing protein 5a (Arid5a)
            cooperates with Sox9 to stimulate chondrocyte-specific
            transcription.
REFERENCE   10 (residues 1 to 590)
  AUTHORS   Wilsker D, Probst L, Wain HM, Maltais L, Tucker PW and Moran E.
  TITLE     Nomenclature of the ARID family of DNA-binding proteins
  JOURNAL   Genomics 86 (2), 242-251 (2005)
   PUBMED   15922553
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY196834.1, AK149839.1 and AK029237.1.
            
            Transcript Variant: This variant (1) represents the predominant
            transcript and encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156376.1, AK149839.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..590
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 15.2 cM"
     Protein         1..590
                     /product="AT-rich interactive domain-containing protein 5A
                     isoform 1"
                     /note="AT rich interactive domain 5A (Mrf1 like);
                     modulator recognition factor I; AT-rich interactive
                     domain-containing protein 5A; ARID domain-containing
                     protein 5A; AT rich interactive domain 5A (MRF1-like)"
                     /calculated_mol_wt=63768
     Region          1..294
                     /region_name="Interaction with SOX9.
                     /evidence=ECO:0000269|PubMed:21346191"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3U108.1)"
     Region          1..52
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3U108.1)"
     Site            24
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q3U108.1)"
     Region          56..138
                     /region_name="ARID_ARID5A"
                     /note="ARID/BRIGHT DNA binding domain of AT-rich
                     interactive domain-containing protein 5A (ARID5A) and
                     similar proteins; cd16884"
                     /db_xref="CDD:350648"
     Site            order(73..79,104,106..107,110,121,123..125,127)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:350648"
     Region          141..229
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3U108.1)"
     Site            253
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:28168301; propagated from
                     UniProtKB/Swiss-Prot (Q3U108.1)"
     Region          275..323
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3U108.1)"
     Site            283
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q3U108.1)"
     Region          367..402
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3U108.1)"
     Region          419..443
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3U108.1)"
     Site            433
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:28168301; propagated from
                     UniProtKB/Swiss-Prot (Q3U108.1)"
     Site            458
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:28168301; propagated from
                     UniProtKB/Swiss-Prot (Q3U108.1)"
     CDS             1..590
                     /gene="Arid5a"
                     /gene_synonym="D430024K22Rik; Mrf1"
                     /coded_by="NM_001172205.1:101..1873"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS48239.1"
                     /db_xref="GeneID:214855"
                     /db_xref="MGI:MGI:2443039"
ORIGIN      
        1 maappakgnt eqseegdlpq lpvspkpdde qsrsqsptql qdspeaggeq eeeqaflvsl
       61 ykfmkerhtp iervphlgfk qinlwkiyka veklgayelv tgrrlwknvy delggspgst
      121 saatctrrhy erlvlpyvrh lkgeddkplp ptkprkqykm akelrgddgt teklkkakds
      181 eerrveqttp gktksdatgq tqlpcqgssr dsteqlgpvs gpsppltgas scpeaykrll
      241 ssfyckgahg imsplakkkl laqvskaeal qcqeegcrhg arspnkdiqd spqnlrgpae
      301 nsehqltpre glqapggstr meaqvgpcpt apmfsgcfha yptevlkpvs qhprdffsgl
      361 kdrvllgppg keegpttkes hlvwggdanh psafhkgstr krsfypkpka cwvspmakvp
      421 terpgapsph psspglgskr gleeegfahg gkklravspf lkevdsketg gkpaapglav
      481 scllgptpgp tppeayrgtm lrcplnftgs adplkgqasl pfsplvipaf pahllattgs
      541 spmaaslmhf pptpydavlr nrlgpassaw hmppvttyaa phffhlntkl
//
LOCUS       NP_001394507             426 aa            linear   ROD 09-OCT-2023
DEFINITION  mitogen-activated protein kinase 10 isoform 3 [Mus musculus].
ACCESSION   NP_001394507
VERSION     NP_001394507.1
DBSOURCE    REFSEQ: accession NM_001407578.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 426)
  AUTHORS   Priego M, Noriega L, Kalinin S, Hoffman LM, Feinstein DL and
            Morfini G.
  TITLE     Genetic deletion of c-Jun amino-terminal kinase 3 (JNK3) modestly
            increases disease severity in a mouse model of multiple sclerosis
  JOURNAL   J Neuroimmunol 382, 578152 (2023)
   PUBMED   37454525
  REMARK    GeneRIF: Genetic deletion of c-Jun amino-terminal kinase 3 (JNK3)
            modestly increases disease severity in a mouse model of multiple
            sclerosis.
REFERENCE   2  (residues 1 to 426)
  AUTHORS   Liu F, Deng Y, Zhao Y, Li Z, Gao J, Zhang Y, Yang X, Liu Y and Xia
            Y.
  TITLE     Time series RNA-seq analysis identifies MAPK10 as a critical gene
            in diabetes mellitus-induced atrial fibrillation in mice
  JOURNAL   J Mol Cell Cardiol 168, 70-82 (2022)
   PUBMED   35489387
  REMARK    GeneRIF: Time series RNA-seq analysis identifies MAPK10 as a
            critical gene in diabetes mellitus-induced atrial fibrillation in
            mice.
REFERENCE   3  (residues 1 to 426)
  AUTHORS   Cunningham JG, Scripter JD, Nti SA and Tucker ES.
  TITLE     Early construction of the thalamocortical axon pathway requires
            c-Jun N-terminal kinase signaling within the ventral forebrain
  JOURNAL   Dev Dyn 251 (3), 459-480 (2022)
   PUBMED   34494344
REFERENCE   4  (residues 1 to 426)
  AUTHORS   Goodwani S, Fernandez C, Acton PJ, Buggia-Prevot V, McReynolds ML,
            Ma J, Hu CH, Hamby ME, Jiang Y, Le K, Soth MJ, Jones P and Ray WJ.
  TITLE     Dual Leucine Zipper Kinase Is Constitutively Active in the Adult
            Mouse Brain and Has Both Stress-Induced and Homeostatic Functions
  JOURNAL   Int J Mol Sci 21 (14), 4849 (2020)
   PUBMED   32659913
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 426)
  AUTHORS   Loughran G, Chou MY, Ivanov IP, Jungreis I, Kellis M, Kiran AM,
            Baranov PV and Atkins JF.
  TITLE     Evidence of efficient stop codon readthrough in four mammalian
            genes
  JOURNAL   Nucleic Acids Res 42 (14), 8928-8938 (2014)
   PUBMED   25013167
REFERENCE   6  (residues 1 to 426)
  AUTHORS   Beier H and Grimm M.
  TITLE     Misreading of termination codons in eukaryotes by natural nonsense
            suppressor tRNAs
  JOURNAL   Nucleic Acids Res 29 (23), 4767-4782 (2001)
   PUBMED   11726686
  REMARK    Review article
REFERENCE   7  (residues 1 to 426)
  AUTHORS   Yang DD, Kuan CY, Whitmarsh AJ, Rincon M, Zheng TS, Davis RJ, Rakic
            P and Flavell RA.
  TITLE     Absence of excitotoxicity-induced apoptosis in the hippocampus of
            mice lacking the Jnk3 gene
  JOURNAL   Nature 389 (6653), 865-870 (1997)
   PUBMED   9349820
REFERENCE   8  (residues 1 to 426)
  AUTHORS   Casanova E, Garate C, Ovalle S, Calvo P and Chinchetru MA.
  TITLE     Identification of four splice variants of the mouse
            stress-activated protein kinase JNK/SAPK alpha-isoform
  JOURNAL   Neuroreport 7 (7), 1320-1324 (1996)
   PUBMED   8817558
REFERENCE   9  (residues 1 to 426)
  AUTHORS   Martin JH, Mohit AA and Miller CA.
  TITLE     Developmental expression in the mouse nervous system of the p493F12
            SAP kinase
  JOURNAL   Brain Res Mol Brain Res 35 (1-2), 47-57 (1996)
   PUBMED   8717339
REFERENCE   10 (residues 1 to 426)
  AUTHORS   Suzuki J, Yoshida S, Chen ZL, Momota Y, Kato K, Hirata A and
            Shiosaka S.
  TITLE     Ontogeny of neuropsin mRNA expression in the mouse brain
  JOURNAL   Neurosci Res 23 (4), 345-351 (1995)
   PUBMED   8602273
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC160244.11, AC123664.15,
            AC137121.9 and AC125252.7.
            
            Summary: The protein encoded by this gene is a member of the MAP
            kinase family. MAP kinases act as integration points for multiple
            biochemical signals, and thus are involved in a wide variety of
            cellular processes, such as proliferation, differentiation,
            transcription regulation and development. This kinase is
            specifically expressed in a subset of neurons in the nervous system
            and is activated by threonine and tyrosine phosphorylation.
            Targeted deletion of this gene in mice suggests that it may have a
            role in stress-induced neuronal apoptosis. Alternatively spliced
            transcript variants encoding different isoforms have been found for
            this gene. A recent study provided evidence for translational
            readthrough in this gene, and expression of an additional
            C-terminally extended isoform via the use of an alternative
            in-frame translation termination codon. [provided by RefSeq, Dec
            2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.4887842.1,
                                           SRR10662773.1399596.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN01164131,
                                           SAMN01164138 [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..426
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 49.61 cM"
     Protein         1..426
                     /product="mitogen-activated protein kinase 10 isoform 3"
                     /EC_number="2.7.11.24"
                     /note="JNK3 beta1 protein kinase; JNK3 beta2 protein
                     kinase; MAP kinase 10; MAP kinase p49 3F12; c-Jun
                     N-terminal kinase 3; stress-activated protein kinase JNK3;
                     SAPK/Erk/kinase 2"
                     /calculated_mol_wt=47997
     Region          25..360
                     /region_name="STKc_JNK"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     c-Jun N-terminal Kinase; cd07850"
                     /db_xref="CDD:270840"
     Site            order(32..38,40,53,55,72,86,108..114,116..117,151,153,
                     155..156,158,168..169,172,183,185..188,190,227)
                     /site_type="active"
                     /db_xref="CDD:270840"
     Site            order(32..38,40,53,55,86,108..114,158,168)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270840"
     Site            order(72,116,151,153,172,183,185..188,190,227)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270840"
     Site            order(112,118,127,130,159..163,323..324,326,329)
                     /site_type="other"
                     /note="KIM docking site [polypeptide binding]"
                     /db_xref="CDD:270840"
     Site            order(168..178,182..190)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270840"
     CDS             1..426
                     /gene="Mapk10"
                     /gene_synonym="C230008H04Rik; JNK3; JNK3B1; JNK3B2;
                     p493F12; p54bSAPK; SAPK(beta); Serk2"
                     /coded_by="NM_001407578.1:662..1942"
                     /note="isoform 3 is encoded by transcript variant 13"
                     /db_xref="GeneID:26414"
                     /db_xref="MGI:MGI:1346863"
ORIGIN      
        1 mskskvdnqf ysvevgdstf tvlkryqnlk pigsgaqgiv caaydavldr nvaikklsrp
       61 fqnqthakra yrelvlmkcv nhkniislln vftpqktlee fqdvylvmel mdanlcqviq
      121 meldhermsy llyqmlcgik hlhsagiihr dlkpsnivvk sdctlkildf glartagtsf
      181 mmtpyvvtry yrapevilgm gykenvdiws vgcimgemvr hkilfpgrdy idqwnkvieq
      241 lgtpcpefmk klqptvrnyv enrpkyaglt fpklfpdslf padsehnklk asqardllsk
      301 mlvidpakri svddalqhpy invwydpaev eapppqiydk qlderehtie ewkeliykev
      361 mnseektkng vvkgqpspsg aavnsseslp psssvndiss mstdqtlasd tdssleasag
      421 plgccr
//
LOCUS       NP_033320                298 aa            linear   ROD 09-OCT-2023
DEFINITION  syntaxin-4 isoform 1 [Mus musculus].
ACCESSION   NP_033320
VERSION     NP_033320.1
DBSOURCE    REFSEQ: accession NM_009294.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 298)
  AUTHORS   Tondeur EGM, Voerman JSA, Geleijnse MAA, van Hofwegen LS, van
            Krimpen A, Koerner J, Mishra G, Song Z and Schliehe C.
  TITLE     Sec22b and Stx4 Depletion Has No Major Effect on Cross-Presentation
            of PLGA Microsphere-Encapsulated Antigen and a Synthetic Long
            Peptide In Vitro
  JOURNAL   J Immunol 211 (8), 1203-1215 (2023)
   PUBMED   37638825
  REMARK    GeneRIF: Sec22b and Stx4 Depletion Has No Major Effect on
            Cross-Presentation of PLGA Microsphere-Encapsulated Antigen and a
            Synthetic Long Peptide In Vitro.
REFERENCE   2  (residues 1 to 298)
  AUTHORS   Black HL, Livingstone R, Mastick CC, Al Tobi M, Taylor H, Geiser A,
            Stirrat L, Kioumourtzoglou D, Petrie JR, Boyle JG, Bryant NJ and
            Gould GW.
  TITLE     Knockout of syntaxin-4 in 3T3-L1 adipocytes reveals new insight
            into GLUT4 trafficking and adiponectin secretion
  JOURNAL   J Cell Sci 135 (1) (2022)
   PUBMED   34859814
  REMARK    GeneRIF: Knockout of syntaxin-4 in 3T3-L1 adipocytes reveals new
            insight into GLUT4 trafficking and adiponectin secretion.
REFERENCE   3  (residues 1 to 298)
  AUTHORS   Merz KE, Hwang J, Zhou C, Veluthakal R, McCown EM, Hamilton A, Oh
            E, Dai W, Fueger PT, Jiang L, Huss JM and Thurmond DC.
  TITLE     Enrichment of the exocytosis protein STX4 in skeletal muscle
            remediates peripheral insulin resistance and alters mitochondrial
            dynamics via Drp1
  JOURNAL   Nat Commun 13 (1), 424 (2022)
   PUBMED   35058456
  REMARK    GeneRIF: Enrichment of the exocytosis protein STX4 in skeletal
            muscle remediates peripheral insulin resistance and alters
            mitochondrial dynamics via Drp1.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 298)
  AUTHORS   Oh E, McCown EM, Ahn M, Garcia PA, Branciamore S, Tang S, Zeng DF,
            Roep BO and Thurmond DC.
  TITLE     Syntaxin 4 Enrichment in beta-Cells Prevents Conversion to
            Autoimmune Diabetes in Non-Obese Diabetic (NOD) Mice
  JOURNAL   Diabetes 70 (12), 2837-2849 (2021)
   PUBMED   34556496
  REMARK    GeneRIF: Syntaxin 4 Enrichment in beta-Cells Prevents Conversion to
            Autoimmune Diabetes in Non-Obese Diabetic (NOD) Mice.
REFERENCE   5  (residues 1 to 298)
  AUTHORS   Sanchez E, Gonzalez EA, Moreno DS, Cardenas RA, Ramos MA, Davalos
            AJ, Manllo J, Rodarte AI, Petrova Y, Moreira DC, Chavez MA,
            Tortoriello A, Lara A, Gutierrez BA, Burns AR, Heidelberger R and
            Adachi R.
  TITLE     Syntaxin 3, but not syntaxin 4, is required for mast cell-regulated
            exocytosis, where it plays a primary role mediating compound
            exocytosis
  JOURNAL   J Biol Chem 294 (9), 3012-3023 (2019)
   PUBMED   30563839
  REMARK    GeneRIF: the residual exocytic function of Stx3-deficient MCs was
            sufficient to drive a full anaphylactic response in mice
REFERENCE   6  (residues 1 to 298)
  AUTHORS   Lehtonen S, Riento K, Olkkonen VM and Lehtonen E.
  TITLE     Syntaxin 3 and Munc-18-2 in epithelial cells during kidney
            development
  JOURNAL   Kidney Int 56 (3), 815-826 (1999)
   PUBMED   10469351
REFERENCE   7  (residues 1 to 298)
  AUTHORS   Min J, Okada S, Kanzaki M, Elmendorf JS, Coker KJ, Ceresa BP, Syu
            LJ, Noda Y, Saltiel AR and Pessin JE.
  TITLE     Synip: a novel insulin-regulated syntaxin 4-binding protein
            mediating GLUT4 translocation in adipocytes
  JOURNAL   Mol Cell 3 (6), 751-760 (1999)
   PUBMED   10394363
  REMARK    Erratum:[Mol Cell 1999 Jul;4(1):following 142]
REFERENCE   8  (residues 1 to 298)
  AUTHORS   Gerst JE.
  TITLE     SNAREs and SNARE regulators in membrane fusion and exocytosis
  JOURNAL   Cell Mol Life Sci 55 (5), 707-734 (1999)
   PUBMED   10379359
  REMARK    Review article
REFERENCE   9  (residues 1 to 298)
  AUTHORS   Tellam JT, Macaulay SL, McIntosh S, Hewish DR, Ward CW and James
            DE.
  TITLE     Characterization of Munc-18c and syntaxin-4 in 3T3-L1 adipocytes.
            Putative role in insulin-dependent movement of GLUT-4
  JOURNAL   J Biol Chem 272 (10), 6179-6186 (1997)
   PUBMED   9045631
REFERENCE   10 (residues 1 to 298)
  AUTHORS   Katagiri H, Terasaki J, Murata T, Ishihara H, Ogihara T, Inukai K,
            Fukushima Y, Anai M, Kikuchi M, Miyazaki J et al.
  TITLE     A novel isoform of syntaxin-binding protein homologous to yeast
            Sec1 expressed ubiquitously in mammalian cells
  JOURNAL   J Biol Chem 270 (10), 4963-4966 (1995)
   PUBMED   7890599
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC149222.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011491.1, AK145909.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..298
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.77 cM"
     Protein         1..298
                     /product="syntaxin-4 isoform 1"
                     /note="syntaxin-4"
                     /calculated_mol_wt=34034
     Site            15
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:19144319, ECO:0007744|PubMed:21183079;
                     propagated from UniProtKB/Swiss-Prot (P70452.1)"
     Site            29
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19144319; propagated from
                     UniProtKB/Swiss-Prot (P70452.1)"
     Site            36
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q12846; propagated from
                     UniProtKB/Swiss-Prot (P70452.1)"
     Region          39..189
                     /region_name="SynN"
                     /note="Syntaxin N-terminus domain; syntaxins are nervous
                     system-specific proteins implicated in the docking of
                     synaptic vesicles with the presynaptic plasma membrane;
                     they are a family of receptors for intracellular transport
                     vesicles; each target membrane may...; cd00179"
                     /db_xref="CDD:238105"
     Site            order(42,49,121..122,125..126,129,132..133,139,142,174)
                     /site_type="active"
                     /note="nSec1 interaction sites [active]"
                     /db_xref="CDD:238105"
     Site            order(69,80,83..84,91,95,98,105,127,132,135,141,148..149,
                     152..153,155..156,159,186)
                     /site_type="active"
                     /note="interdomain interaction site [active]"
                     /db_xref="CDD:238105"
     Site            117
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19131326,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P70452.1)"
     Region          154..298
                     /region_name="Interaction with CENPF.
                     /evidence=ECO:0000269|PubMed:18827011"
                     /note="propagated from UniProtKB/Swiss-Prot (P70452.1)"
     Site            order(166..176,185..189)
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238105"
     Region          199..260
                     /region_name="SNARE"
                     /note="SNARE motif; cl22856"
                     /db_xref="CDD:451431"
     Site            208
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P70452.1)"
     Site            order(231,238,241)
                     /site_type="other"
                     /note="flanking leucine-zipper layers"
                     /db_xref="CDD:277192"
     Site            234
                     /site_type="active"
                     /note="zero layer [active]"
                     /db_xref="CDD:277192"
     Region          236..287
                     /region_name="SNARE"
                     /note="SNARE domain; pfam05739"
                     /db_xref="CDD:428611"
     Site            248
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19144319; propagated from
                     UniProtKB/Swiss-Prot (P70452.1)"
     Site            275..295
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P70452.1)"
     Site            290
                     /site_type="other"
                     /note="Required for neurite tip localization.
                     /evidence=ECO:0000250|UniProtKB:Q08850; propagated from
                     UniProtKB/Swiss-Prot (P70452.1)"
     CDS             1..298
                     /gene="Stx4a"
                     /gene_synonym="Stx4; Syn-4; Syn4"
                     /coded_by="NM_009294.4:276..1172"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS21880.1"
                     /db_xref="GeneID:20909"
                     /db_xref="MGI:MGI:893577"
ORIGIN      
        1 mrdrthelrq gdnisddede vrvalvvhsg aarlgspdde ffqkvqtirq tmakleskvr
       61 elekqqvtil atplpeesmk qglqnlreei kqlgrevraq lkaiepqkee adenynsvnt
      121 rmkktqhgvl sqqfvelink cnsmqseyre knverirrql kitnagmvsd eeleqmldsg
      181 qsevfvsnil kdtqvtrqal neisarhsei qqlersirel heiftflate vemqgeminr
      241 ieknilssad yvergqehvk ialenqkkar kkkvmiaicv svtvlilavi igititvg
//
LOCUS       NP_001349226             505 aa            linear   ROD 09-OCT-2023
DEFINITION  CUGBP Elav-like family member 4 isoform 21 [Mus musculus].
ACCESSION   NP_001349226 XP_006525575
VERSION     NP_001349226.1
DBSOURCE    REFSEQ: accession NM_001362297.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 505)
  AUTHORS   Salamon I, Park Y, Miskic T, Kopic J, Matteson P, Page NF, Roque A,
            McAuliffe GW, Favate J, Garcia-Forn M, Shah P, Judas M, Millonig
            JH, Kostovic I, De Rubeis S, Hart RP, Krsnik Z and Rasin MR.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    GeneRIF: Celf4 controls mRNA translation underlying synaptic
            development in the prenatal mammalian neocortex.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 505)
  AUTHORS   Shen Y, Zhang C, Xiao K, Liu D and Xie G.
  TITLE     CELF4 regulates spine formation and depression-like behaviors of
            mice
  JOURNAL   Biochem Biophys Res Commun 605, 39-44 (2022)
   PUBMED   35306363
  REMARK    GeneRIF: CELF4 regulates spine formation and depression-like
            behaviors of mice.
REFERENCE   3  (residues 1 to 505)
  AUTHORS   Moreau MX, Saillour Y, Cwetsch AW, Pierani A and Causeret F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   4  (residues 1 to 505)
  AUTHORS   Li C, Li X, Bi Z, Sugino K, Wang G, Zhu T and Liu Z.
  TITLE     Comprehensive transcriptome analysis of cochlear spiral ganglion
            neurons at multiple ages
  JOURNAL   Elife 9, e50491 (2020)
   PUBMED   31913118
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 505)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 505)
  AUTHORS   Ladd AN, Taffet G, Hartley C, Kearney DL and Cooper TA.
  TITLE     Cardiac tissue-specific repression of CELF activity disrupts
            alternative splicing and causes cardiomyopathy
  JOURNAL   Mol Cell Biol 25 (14), 6267-6278 (2005)
   PUBMED   15988035
  REMARK    GeneRIF: CELF protein activity is required for normal alternative
            splicing in the heart in vivo and normal CELF-mediated alternative
            splicing regulation is in turn required for normal cardiac
            function.
REFERENCE   7  (residues 1 to 505)
  AUTHORS   Meins M, Schlickum S, Wilhelm C, Missbach J, Yadav S, Glaser B,
            Grzmil M, Burfeind P and Laccone F.
  TITLE     Identification and characterization of murine Brunol4, a new member
            of the elav/bruno family
  JOURNAL   Cytogenet Genome Res 97 (3-4), 254-260 (2002)
   PUBMED   12438720
  REMARK    GeneRIF: cloning and characterization
REFERENCE   8  (residues 1 to 505)
  AUTHORS   Ladd AN, Charlet N and Cooper TA.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   9  (residues 1 to 505)
  AUTHORS   Good PJ, Chen Q, Warner SJ and Herring DC.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
REFERENCE   10 (residues 1 to 505)
  AUTHORS   Yulug IG, Egan SE, See CG and Fisher EM.
  TITLE     Mapping GRB2, a signal transduction gene in the human and the mouse
  JOURNAL   Genomics 22 (2), 313-318 (1994)
   PUBMED   7806216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121094.8 and AC144938.3.
            
            On Apr 12, 2018 this sequence version replaced XP_006525575.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.63569.1,
                                           SRR1660819.73300.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..505
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 13.92 cM"
     Protein         1..505
                     /product="CUGBP Elav-like family member 4 isoform 21"
                     /note="CUG-BP- and ETR-3-like factor 4; bruno-like protein
                     4; RNA-binding protein BRUNOL-4; bruno-like 4, RNA binding
                     protein"
                     /calculated_mol_wt=53913
     Region          49..135
                     /region_name="RRM1_CELF3_4_5_6"
                     /note="RNA recognition motif 1 (RRM1) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12632"
                     /db_xref="CDD:410041"
     Site            order(55,57,59..60,63,82,84,86,95..97,99,129,131)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410041"
     Region          <56..378
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     Region          151..231
                     /region_name="RRM2_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12635"
                     /db_xref="CDD:410043"
     Site            order(153,155,157..158,161,180,182,184,192..194,196,226,
                     228)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410043"
     Region          416..494
                     /region_name="RRM3_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12639"
                     /db_xref="CDD:241083"
     CDS             1..505
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /coded_by="NM_001362297.1:531..2048"
                     /note="isoform 21 is encoded by transcript variant 27"
                     /db_xref="GeneID:108013"
                     /db_xref="MGI:MGI:1932407"
ORIGIN      
        1 myikmatlan gqadnaslst nglgsspgsa ghmnglshsp gnpstipmkd hdaiklfigq
       61 iprnldekdl kplfeefgki yeltvlkdrf tgmhkgcafl tyceresalk aqsalheqkt
      121 lpgmnrpiqv kpadsesrgg ssclrqppsq drklfvgmln kqqseddvrr lfeafgniee
      181 ctilrgpdgn skgcafvkys shaeaqaain alhgsqtmpg assslvvkfa dtdkertmrr
      241 mqqmagqmgm fnpmaipfga ygayaqalmq qqaalmasva qggylnpmaa faaaqmqqma
      301 alnmnglaaa pmtptsggst ppgitapavp sipspigvng ftglppqang qpaaeavfan
      361 gihpypaqsp taadplqqay agvqqyagpa ypaaygqisq afpqpppmip qqqregpegc
      421 nlliyhlpqe fgdaelmqmf lpfgnvissk vfvdratnqs kcfgfvsfdn pasaqtaiqa
      481 mngfqigmkr lkvqlkrpkd anrpy
//
LOCUS       NP_032196               1464 aa            linear   ROD 09-OCT-2023
DEFINITION  glutamate receptor ionotropic, NMDA 2A precursor [Mus musculus].
ACCESSION   NP_032196 XP_006521857 XP_358759
VERSION     NP_032196.2
DBSOURCE    REFSEQ: accession NM_008170.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1464)
  AUTHORS   Su T, Lu Y, Fu C, Geng Y and Chen Y.
  TITLE     GluN2A mediates ketamine-induced rapid antidepressant-like
            responses
  JOURNAL   Nat Neurosci 26 (10), 1751-1761 (2023)
   PUBMED   37709995
  REMARK    GeneRIF: GluN2A mediates ketamine-induced rapid antidepressant-like
            responses.
REFERENCE   2  (residues 1 to 1464)
  AUTHORS   Camp CR, Vlachos A, Klockner C, Krey I, Banke TG, Shariatzadeh N,
            Ruggiero SM, Galer P, Park KL, Caccavano A, Kimmel S, Yuan X, Yuan
            H, Helbig I, Benke TA, Lemke JR, Pelkey KA, McBain CJ and Traynelis
            SF.
  TITLE     Loss of Grin2a causes a transient delay in the electrophysiological
            maturation of hippocampal parvalbumin interneurons
  JOURNAL   Commun Biol 6 (1), 952 (2023)
   PUBMED   37723282
  REMARK    GeneRIF: Loss of Grin2a causes a transient delay in the
            electrophysiological maturation of hippocampal parvalbumin
            interneurons.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1464)
  AUTHORS   Herzog LE, Wang L, Yu E, Choi S, Farsi Z, Song BJ, Pan JQ and Sheng
            M.
  TITLE     Mouse mutants in schizophrenia risk genes GRIN2A and AKAP11 show
            EEG abnormalities in common with schizophrenia patients
  JOURNAL   Transl Psychiatry 13 (1), 92 (2023)
   PUBMED   36914641
  REMARK    GeneRIF: Mouse mutants in schizophrenia risk genes GRIN2A and
            AKAP11 show EEG abnormalities in common with schizophrenia
            patients.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1464)
  AUTHORS   Wischhof L, Lee HM, Tutas J, Overkott C, Tedt E, Stork M, Peitz M,
            Brustle O, Ulas T, Handler K, Schultze JL, Ehninger D, Nicotera P,
            Salomoni P and Bano D.
  TITLE     BCL7A-containing SWI/SNF/BAF complexes modulate mitochondrial
            bioenergetics during neural progenitor differentiation
  JOURNAL   EMBO J 41 (23), e110595 (2022)
   PUBMED   36305367
REFERENCE   5  (residues 1 to 1464)
  AUTHORS   Haddow K, Kind PC and Hardingham GE.
  TITLE     NMDA Receptor C-Terminal Domain Signalling in Development,
            Maturity, and Disease
  JOURNAL   Int J Mol Sci 23 (19), 11392 (2022)
   PUBMED   36232696
  REMARK    GeneRIF: NMDA Receptor C-Terminal Domain Signalling in Development,
            Maturity, and Disease.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1464)
  AUTHORS   Watanabe M, Mishina M and Inoue Y.
  TITLE     Differential distributions of the NMDA receptor channel subunit
            mRNAs in the mouse retina
  JOURNAL   Brain Res 634 (2), 328-332 (1994)
   PUBMED   7510577
REFERENCE   7  (residues 1 to 1464)
  AUTHORS   Watanabe M, Inoue Y, Sakimura K and Mishina M.
  TITLE     Developmental changes in distribution of NMDA receptor channel
            subunit mRNAs
  JOURNAL   Neuroreport 3 (12), 1138-1140 (1992)
   PUBMED   1493227
REFERENCE   8  (residues 1 to 1464)
  AUTHORS   Ikeda K, Nagasawa M, Mori H, Araki K, Sakimura K, Watanabe M, Inoue
            Y and Mishina M.
  TITLE     Cloning and expression of the epsilon 4 subunit of the NMDA
            receptor channel
  JOURNAL   FEBS Lett 313 (1), 34-38 (1992)
   PUBMED   1385220
REFERENCE   9  (residues 1 to 1464)
  AUTHORS   Kutsuwada T, Kashiwabuchi N, Mori H, Sakimura K, Kushiya E, Araki
            K, Meguro H, Masaki H, Kumanishi T, Arakawa M et al.
  TITLE     Molecular diversity of the NMDA receptor channel
  JOURNAL   Nature 358 (6381), 36-41 (1992)
   PUBMED   1377365
REFERENCE   10 (residues 1 to 1464)
  AUTHORS   Meguro H, Mori H, Araki K, Kushiya E, Kutsuwada T, Yamazaki M,
            Kumanishi T, Arakawa M, Sakimura K and Mishina M.
  TITLE     Functional characterization of a heteromeric NMDA receptor channel
            expressed from cloned cDNAs
  JOURNAL   Nature 357 (6373), 70-74 (1992)
   PUBMED   1374164
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC164163.2, AC154190.2, AC121974.3 and AC126022.4.
            
            On or before Apr 18, 2018 this sequence version replaced
            XP_006521857.1, XP_358759.2, NP_032196.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219381.176123.1,
                                           ERR3363660.655756.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1464
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 5.28 cM"
     Protein         1..1464
                     /product="glutamate receptor ionotropic, NMDA 2A
                     precursor"
                     /note="glutamate [NMDA] receptor subunit epsilon-1;
                     N-methyl D-aspartate receptor subtype 2A; glutamate
                     receptor ionotropic, NMDA 2A"
                     /calculated_mol_wt=162521
     sig_peptide     1..27
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=2919
     Region          32..387
                     /region_name="PBP1_iGluR_NMDA_NR2"
                     /note="N-terminal leucine-isoleucine-valine-binding
                     protein (LIVBP)-like domain of the NR2 subunit of NMDA
                     receptor family; cd06378"
                     /db_xref="CDD:380601"
     Site            order(32,78..80,115,136,176,178,193,208..209,310..311)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:380601"
     Site            order(76..81,83..84,119..120,176,180,207,209,310..316,
                     320..322,333)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:380601"
     Region          403..802
                     /region_name="PBP2_iGluR_NMDA_Nr2"
                     /note="The ligand-binding domain of the NR2 subunit of
                     ionotropic NMDA (N-methyl-D-aspartate) glutamate
                     receptors, a member of the type 2 periplasmic binding fold
                     protein superfamily; cd13718"
                     /db_xref="CDD:270436"
     Site            order(511..514,516,518..520,666,688..689,693,731,756..758,
                     761,767,783..786,789)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:270436"
     Site            order(511..513,518,688..690,730..731)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:270436"
     Region          839..1464
                     /region_name="NMDAR2_C"
                     /note="N-methyl D-aspartate receptor 2B3 C-terminus;
                     pfam10565"
                     /db_xref="CDD:431361"
     CDS             1..1464
                     /gene="Grin2a"
                     /gene_synonym="GluN2A; GluRepsilon1; NMDAR2A; NR2A"
                     /coded_by="NM_008170.4:1201..5595"
                     /db_xref="CCDS:CCDS27943.1"
                     /db_xref="GeneID:14811"
                     /db_xref="MGI:MGI:95820"
ORIGIN      
        1 mgrlgywtll vlpallvwhg paqnaaaekg tpalniavll ghshdvtere lrnlwgpeqa
       61 tglpldvnvv allmnrtdpk slithvcdlm sgarihglvf gddtdqeava qmldfissqt
      121 fipilgihgg asmimadkdp tstffqfgas iqqqatvmlk imqdydwhvf slvttifpgy
      181 rdfisfiktt vdnsfvgwdm qnvitldtsf edaktqvqlk kihssvilly cskdeavlil
      241 searslgltg ydffwivpsl vsgntelipk efpsglisvs yddwdyslea rvrdglgilt
      301 taassmlekf syipeakasc ygqtekpetp lhtlhqfmvn vtwdgkdlsf teegyqvhpr
      361 lvvivlnkdr ewekvgkwen qtlslrhavw pryksfsdce pddnhlsivt leeapfvive
      421 didpltetcv rntvpcrkfv kinnstnegm nvkkcckgfc idilkklsrt vkftydlylv
      481 tngkhgkkvn nvwngmigev vyqravmavg sltineerse vvdfsvpfve tgisvmvsrs
      541 ngtvspsafl epfsasvwvm mfvmllivsa iavfvfeyfs pvgynrnlak gkaphgpsft
      601 igkaiwllwg lvfnnsvpvq npkgttskim vsvwaffavi flasytanla afmiqeefvd
      661 qvtglsdkkf qrphdysppf rfgtvpngst ernirnnypy mhqymtkfnq rgvedalvsl
      721 ktgkldafiy daavlnykag rdegcklvti gsgyifattg ygialqkgsp wkrqidlall
      781 qfvgdgemee letlwltgic hneknevmss qldidnmagv fymlaaamal slitfiwehl
      841 fywklrfcft gvcsdrpgll fsisrgiysc ihgvhieekk kspdfnltgs qsnmlkllrs
      901 aknisnmsnm nssrmdspkr aadfiqrgsl ivdmvsdkgn liysdnrsfq gkdsifgenm
      961 nelqtfvanr hkdslsnyvf qgqhpltlne snpntvevav steskgnsrp rqlwkksmes
     1021 lrqdslnqnp vsqrdektae nrthslkspr ylpeevahsd isetssratc hrepdnnknh
     1081 ktkdnfkrsm askypkdcse vertyvktka ssprdkiyti dgekepsfhl dppqfieniv
     1141 lpenvdfpdt yqdhnenfrk gdstlpmnrn plhnedglpn ndqyklyakh ftlkdkgsph
     1201 segsdryrqn sthcrsclsn lptysghftm rspfkcdacl rmgnlydide dqmlqetgnp
     1261 atreeayqqd wsqnnalqfq knklkinrqh sydnildkpr eidlsrpsrs islkdrerll
     1321 egnlygslfs vpsskllgnk sslfpqgled skrsksllpd htsdnpflht ygddqrlvig
     1381 rcpsdpykhs lpsqavndsy lrsslrstas ycsrdsrghs dvyisehvmp yaanknnmys
     1441 tprvlnscsn rrvykkmpsi esdv
//
LOCUS       NP_001349265             446 aa            linear   ROD 09-OCT-2023
DEFINITION  CUGBP Elav-like family member 4 isoform 54 [Mus musculus].
ACCESSION   NP_001349265 XP_017173290
VERSION     NP_001349265.1
DBSOURCE    REFSEQ: accession NM_001362336.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 446)
  AUTHORS   Salamon I, Park Y, Miskic T, Kopic J, Matteson P, Page NF, Roque A,
            McAuliffe GW, Favate J, Garcia-Forn M, Shah P, Judas M, Millonig
            JH, Kostovic I, De Rubeis S, Hart RP, Krsnik Z and Rasin MR.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    GeneRIF: Celf4 controls mRNA translation underlying synaptic
            development in the prenatal mammalian neocortex.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 446)
  AUTHORS   Shen Y, Zhang C, Xiao K, Liu D and Xie G.
  TITLE     CELF4 regulates spine formation and depression-like behaviors of
            mice
  JOURNAL   Biochem Biophys Res Commun 605, 39-44 (2022)
   PUBMED   35306363
  REMARK    GeneRIF: CELF4 regulates spine formation and depression-like
            behaviors of mice.
REFERENCE   3  (residues 1 to 446)
  AUTHORS   Moreau MX, Saillour Y, Cwetsch AW, Pierani A and Causeret F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   4  (residues 1 to 446)
  AUTHORS   Li C, Li X, Bi Z, Sugino K, Wang G, Zhu T and Liu Z.
  TITLE     Comprehensive transcriptome analysis of cochlear spiral ganglion
            neurons at multiple ages
  JOURNAL   Elife 9, e50491 (2020)
   PUBMED   31913118
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 446)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 446)
  AUTHORS   Ladd AN, Taffet G, Hartley C, Kearney DL and Cooper TA.
  TITLE     Cardiac tissue-specific repression of CELF activity disrupts
            alternative splicing and causes cardiomyopathy
  JOURNAL   Mol Cell Biol 25 (14), 6267-6278 (2005)
   PUBMED   15988035
  REMARK    GeneRIF: CELF protein activity is required for normal alternative
            splicing in the heart in vivo and normal CELF-mediated alternative
            splicing regulation is in turn required for normal cardiac
            function.
REFERENCE   7  (residues 1 to 446)
  AUTHORS   Meins M, Schlickum S, Wilhelm C, Missbach J, Yadav S, Glaser B,
            Grzmil M, Burfeind P and Laccone F.
  TITLE     Identification and characterization of murine Brunol4, a new member
            of the elav/bruno family
  JOURNAL   Cytogenet Genome Res 97 (3-4), 254-260 (2002)
   PUBMED   12438720
  REMARK    GeneRIF: cloning and characterization
REFERENCE   8  (residues 1 to 446)
  AUTHORS   Ladd AN, Charlet N and Cooper TA.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   9  (residues 1 to 446)
  AUTHORS   Good PJ, Chen Q, Warner SJ and Herring DC.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
REFERENCE   10 (residues 1 to 446)
  AUTHORS   Yulug IG, Egan SE, See CG and Fisher EM.
  TITLE     Mapping GRB2, a signal transduction gene in the human and the mouse
  JOURNAL   Genomics 22 (2), 313-318 (1994)
   PUBMED   7806216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121094.8 and AC144938.3.
            
            On Apr 12, 2018 this sequence version replaced XP_017173290.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219381.60563.1,
                                           SRR9219382.92318.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..446
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 13.92 cM"
     Protein         1..446
                     /product="CUGBP Elav-like family member 4 isoform 54"
                     /note="CUG-BP- and ETR-3-like factor 4; bruno-like protein
                     4; RNA-binding protein BRUNOL-4; bruno-like 4, RNA binding
                     protein"
                     /calculated_mol_wt=47396
     Region          49..135
                     /region_name="RRM1_CELF3_4_5_6"
                     /note="RNA recognition motif 1 (RRM1) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12632"
                     /db_xref="CDD:410041"
     Site            order(55,57,59..60,63,82,84,86,95..97,99,129,131)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410041"
     Region          56..442
                     /region_name="ELAV_HUD_SF"
                     /note="ELAV/HuD family splicing factor; TIGR01661"
                     /db_xref="CDD:273741"
     Region          140..220
                     /region_name="RRM2_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12635"
                     /db_xref="CDD:410043"
     Site            order(142,144,146..147,150,169,171,173,181..183,185,215,
                     217)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410043"
     CDS             1..446
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /coded_by="NM_001362336.1:531..1871"
                     /note="isoform 54 is encoded by transcript variant 55"
                     /db_xref="GeneID:108013"
                     /db_xref="MGI:MGI:1932407"
ORIGIN      
        1 myikmatlan gqadnaslst nglgsspgsa ghmnglshsp gnpstipmkd hdaiklfigq
       61 iprnldekdl kplfeefgki yeltvlkdrf tgmhkgcafl tyceresalk aqsalheqkt
      121 lpgmnrpiqv kpadsesrgd rklfvgmlnk qqseddvrrl feafgnieec tilrgpdgns
      181 kgcafvkyss haeaqaaina lhgsqtmpga ssslvvkfad tdkertmrrm qqmagqmgmf
      241 npmaipfgay gayaqalmqq qaalmasvaq ggylnpmaaf aaaqmqqmaa lnmnglaaap
      301 mtptsggstp pgitapavps ipspigvngf tglppqangq paaeavfang ihpypaqspt
      361 aadplqqaya gvqqyagpay paaygqisqa fpqpppmipq qqregfvsfd npasaqtaiq
      421 amngfqigmk rlkvqlkrpk danrpy
//
LOCUS       NP_001002011             665 aa            linear   ROD 09-OCT-2023
DEFINITION  prelamin-A/C isoform A precursor [Mus musculus].
ACCESSION   NP_001002011
VERSION     NP_001002011.2
DBSOURCE    REFSEQ: accession NM_001002011.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 665)
  AUTHORS   Kim JR, Kim PH, Presnell A, Tu Y and Young SG.
  TITLE     Revisiting the truncated lamin A produced by a commonly used strain
            of Lmna knockout mice
  JOURNAL   Nucleus 14 (1), 2262308 (2023)
   PUBMED   37754663
  REMARK    GeneRIF: Revisiting the truncated lamin A produced by a commonly
            used strain of Lmna knockout mice.
REFERENCE   2  (residues 1 to 665)
  AUTHORS   Chang L, Huang R, Chen J, Li G, Shi G, Xu B and Wang L.
  TITLE     An alpha-helix variant p.Arg156Pro in LMNA as a cause of hereditary
            dilated cardiomyopathy: genetics and bioinfomatics exploration
  JOURNAL   BMC Med Genomics 16 (1), 229 (2023)
   PUBMED   37784143
  REMARK    GeneRIF: An alpha-helix variant p.Arg156Pro in LMNA as a cause of
            hereditary dilated cardiomyopathy: genetics and bioinfomatics
            exploration.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 665)
  AUTHORS   Pruvost M, Patzig J, Yattah C, Selcen I, Hernandez M, Park HJ,
            Moyon S, Liu S, Morioka MS, Shopland L, Al-Dalahmah O, Bendl J,
            Fullard JF, Roussos P, Goldman J, He Y, Dupree JL and Casaccia P.
  TITLE     The stability of the myelinating oligodendrocyte transcriptome is
            regulated by the nuclear lamina
  JOURNAL   Cell Rep 42 (8), 112848 (2023)
   PUBMED   37515770
REFERENCE   4  (residues 1 to 665)
  AUTHORS   Jahn D, Schramm S, Benavente R and Alsheimer M.
  TITLE     Dynamic properties of meiosis-specific lamin C2 and its impact on
            nuclear envelope integrity
  JOURNAL   Nucleus 1 (3), 273-283 (2010)
   PUBMED   21327075
  REMARK    GeneRIF: lamin C2 as a 'natural lamin deletion mutant' that confers
            unique properties to the nuclear envelope which would be essential
            for dynamic telomere repositioning during meiotic prophase I
REFERENCE   5  (residues 1 to 665)
  AUTHORS   Sullivan T, Escalante-Alcalde D, Bhatt H, Anver M, Bhat N,
            Nagashima K, Stewart CL and Burke B.
  TITLE     Loss of A-type lamin expression compromises nuclear envelope
            integrity leading to muscular dystrophy
  JOURNAL   J Cell Biol 147 (5), 913-920 (1999)
   PUBMED   10579712
REFERENCE   6  (residues 1 to 665)
  AUTHORS   Eggert M, Radomski N, Tripier D, Traub P and Jost E.
  TITLE     Identification of phosphorylation sites on murine nuclear lamin C
            by RP-HPLC and microsequencing
  JOURNAL   FEBS Lett 292 (1-2), 205-209 (1991)
   PUBMED   1959608
REFERENCE   7  (residues 1 to 665)
  AUTHORS   Weber K, Plessmann U and Traub P.
  TITLE     Maturation of nuclear lamin A involves a specific carboxy-terminal
            trimming, which removes the polyisoprenylation site from the
            precursor; implications for the structure of the nuclear lamina
  JOURNAL   FEBS Lett 257 (2), 411-414 (1989)
   PUBMED   2583287
REFERENCE   8  (residues 1 to 665)
  AUTHORS   Riedel W and Werner D.
  TITLE     Nucleotide sequence of the full-length mouse lamin C cDNA and its
            deduced amino-acid sequence
  JOURNAL   Biochim Biophys Acta 1008 (1), 119-122 (1989)
   PUBMED   2719959
REFERENCE   9  (residues 1 to 665)
  AUTHORS   Rober RA, Weber K and Osborn M.
  TITLE     Differential timing of nuclear lamin A/C expression in the various
            organs of the mouse embryo and the young animal: a developmental
            study
  JOURNAL   Development 105 (2), 365-378 (1989)
   PUBMED   2680424
REFERENCE   10 (residues 1 to 665)
  AUTHORS   Houliston E, Guilly MN, Courvalin JC and Maro B.
  TITLE     Expression of nuclear lamins during mouse preimplantation
            development
  JOURNAL   Development 102 (2), 271-278 (1988)
   PUBMED   3046911
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC145168.5, AK147150.1,
            AK004619.2 and AW047412.1.
            
            On Dec 11, 2007 this sequence version replaced NP_001002011.1.
            
            Summary: This gene encodes a protein that is a member of the lamin
            family. Nuclear lamins, intermediate filament-like proteins, are
            the major components of the nuclear lamina, a protein meshwork
            associated with the inner nuclear membrane. This meshwork is
            thought to maintain the integrity of the nuclear envelope,
            participate in chromatin organization, and regulate gene
            transcription. Vertebrate lamins consist of two types, A and B.
            This protein is an A-type and is proposed to be developmentally
            regulated. In mouse deficiency of this gene is associated with
            muscular dystrophy. Mouse lines with different mutations in this
            gene serve as pathophysiological models for several human
            laminopathies. In humans, mutations in this gene lead to several
            diseases: Emery-Dreifuss muscular dystrophy, familial partial
            lipodystrophy, limb girdle muscular dystrophy, dilated
            cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford
            progeria syndrome. Alternative splicing results in multiple
            transcript variants that encode different protein isoforms.
            [provided by RefSeq, May 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (A).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004619.2, AK147150.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..665
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 38.84 cM"
     Protein         1..665
                     /product="prelamin-A/C isoform A precursor"
                     /note="prelamin-A/C; lamin-A/C; lamin C"
                     /calculated_mol_wt=74107
     mat_peptide     1..662
                     /product="Prelamin-A/C. /id=PRO_0000398837"
                     /note="propagated from UniProtKB/Swiss-Prot (P48678.2)"
                     /calculated_mol_wt=73906
     mat_peptide     1..647
                     /product="Lamin-A/C. /id=PRO_0000063811"
                     /note="propagated from UniProtKB/Swiss-Prot (P48678.2)"
                     /calculated_mol_wt=72347
     Region          1..130
                     /region_name="Interaction with MLIP.
                     /evidence=ECO:0000250|UniProtKB:P02545"
                     /note="propagated from UniProtKB/Swiss-Prot (P48678.2)"
     Region          1..33
                     /region_name="Head"
                     /note="propagated from UniProtKB/Swiss-Prot (P48678.2)"
     Region          1..25
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P48678.2)"
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            3
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            12
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            18
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            19
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            22
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:19144319, ECO:0007744|PubMed:21183079;
                     propagated from UniProtKB/Swiss-Prot (P48678.2)"
     Region          30..386
                     /region_name="Filament"
                     /note="Intermediate filament protein; pfam00038"
                     /db_xref="CDD:425436"
     Site            32
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Region          34..70
                     /region_name="Coil 1A"
                     /note="propagated from UniProtKB/Swiss-Prot (P48678.2)"
     Site            51
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            66
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Region          71..80
                     /region_name="Linker 1"
                     /note="propagated from UniProtKB/Swiss-Prot (P48678.2)"
     Site            71
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Region          81..218
                     /region_name="Coil 1B"
                     /note="propagated from UniProtKB/Swiss-Prot (P48678.2)"
     Site            107
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            108
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            123
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            135
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            155
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            171
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            201
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            212
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Region          219..242
                     /region_name="Linker 2"
                     /note="propagated from UniProtKB/Swiss-Prot (P48678.2)"
     Region          243..383
                     /region_name="Coil 2"
                     /note="propagated from UniProtKB/Swiss-Prot (P48678.2)"
     Site            260
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            266
                     /site_type="other"
                     /note="Heptad change of phase; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            270
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            277
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            301
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            307
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            311
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            325
                     /site_type="other"
                     /note="Stutter. /evidence=ECO:0000305; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            330
                     /site_type="other"
                     /note="Heptad change of phase; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Region          384..665
                     /region_name="Tail"
                     /note="propagated from UniProtKB/Swiss-Prot (P48678.2)"
     Region          384..442
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P48678.2)"
     Site            390
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19131326,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            392
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:1959608; Phosphoserine, by
                     CDK1. /evidence=ECO:0000269|PubMed:1959608,
                     ECO:0007744|PubMed:19131326, ECO:0007744|PubMed:21183079;
                     propagated from UniProtKB/Swiss-Prot (P48678.2)"
     Site            395
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            398
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            403
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            404
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            407
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:1959608; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            409
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:1959608; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            414
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Region          417..422
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (P48678.2)"
     Site            429
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            431
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Region          434..541
                     /region_name="LTD"
                     /note="Lamin Tail Domain; pfam00932"
                     /db_xref="CDD:425951"
     Site            450
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            457
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            458
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            460
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            463
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            496
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P48679; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            500
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P48679; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            505
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            510
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P48679; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            533
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            546
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19144319; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            548
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Region          553..577
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P48678.2)"
     Site            570
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            572
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            573
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            613
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            614
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            617
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            620
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            629
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            633
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            637
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            647..648
                     /site_type="cleavage"
                     /note="Cleavage, by endoprotease.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            653
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            662
                     /site_type="methylation"
                     /note="Cysteine methyl ester.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     CDS             1..665
                     /gene="Lmna"
                     /gene_synonym="Dhe"
                     /coded_by="NM_001002011.3:250..2247"
                     /note="isoform A precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS38482.1"
                     /db_xref="GeneID:16905"
                     /db_xref="MGI:MGI:96794"
ORIGIN      
        1 metpsqrrat rsgaqasstp lsptritrlq ekedlqelnd rlavyidrvr sletenaglr
       61 lriteseevv srevsgikaa yeaelgdark tldsvakera rlqlelskvr eefkelkarn
      121 tkkegdllaa qarlkdleal lnskeaalst alsekrtleg elhdlrgqva kleaalgeak
      181 kqlqdemlrr vdaenrlqtl keeldfqkni yseelretkr rhetrlveid ngkqrefesr
      241 ladalqelra qhedqveqyk kelektysak ldnarqsaer nsnlvgaahe elqqsririd
      301 slsaqlsqlq kqlaakeakl rdledslare rdtsrrllae keremaemra rmqqqldeyq
      361 elldiklald meihayrkll egeeerlrls psptsqrsrg rasshssqsq gggsvtkkrk
      421 lessesrssf sqhartsgrv aveevdeegk fvrlrnksne dqsmgnwqir rqngddplmt
      481 yrfppkftlk agqvvtiwas gagathsppt dlvwkaqntw gcgsslrtal instgeevam
      541 rklvrsltmv ednedddedg eellhhhrgs hcsgsgdpae ynlrsrtvlc gtcgqpadka
      601 aggagaqvgg sissgssass vtvtrsfrsv ggsgggsfgd nlvtrsyllg nssprsqssq
      661 ncsim
//
LOCUS       NP_001349256             475 aa            linear   ROD 09-OCT-2023
DEFINITION  CUGBP Elav-like family member 4 isoform 45 [Mus musculus].
ACCESSION   NP_001349256 XP_017173287
VERSION     NP_001349256.1
DBSOURCE    REFSEQ: accession NM_001362327.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 475)
  AUTHORS   Salamon I, Park Y, Miskic T, Kopic J, Matteson P, Page NF, Roque A,
            McAuliffe GW, Favate J, Garcia-Forn M, Shah P, Judas M, Millonig
            JH, Kostovic I, De Rubeis S, Hart RP, Krsnik Z and Rasin MR.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    GeneRIF: Celf4 controls mRNA translation underlying synaptic
            development in the prenatal mammalian neocortex.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 475)
  AUTHORS   Shen Y, Zhang C, Xiao K, Liu D and Xie G.
  TITLE     CELF4 regulates spine formation and depression-like behaviors of
            mice
  JOURNAL   Biochem Biophys Res Commun 605, 39-44 (2022)
   PUBMED   35306363
  REMARK    GeneRIF: CELF4 regulates spine formation and depression-like
            behaviors of mice.
REFERENCE   3  (residues 1 to 475)
  AUTHORS   Moreau MX, Saillour Y, Cwetsch AW, Pierani A and Causeret F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   4  (residues 1 to 475)
  AUTHORS   Li C, Li X, Bi Z, Sugino K, Wang G, Zhu T and Liu Z.
  TITLE     Comprehensive transcriptome analysis of cochlear spiral ganglion
            neurons at multiple ages
  JOURNAL   Elife 9, e50491 (2020)
   PUBMED   31913118
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 475)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 475)
  AUTHORS   Ladd AN, Taffet G, Hartley C, Kearney DL and Cooper TA.
  TITLE     Cardiac tissue-specific repression of CELF activity disrupts
            alternative splicing and causes cardiomyopathy
  JOURNAL   Mol Cell Biol 25 (14), 6267-6278 (2005)
   PUBMED   15988035
  REMARK    GeneRIF: CELF protein activity is required for normal alternative
            splicing in the heart in vivo and normal CELF-mediated alternative
            splicing regulation is in turn required for normal cardiac
            function.
REFERENCE   7  (residues 1 to 475)
  AUTHORS   Meins M, Schlickum S, Wilhelm C, Missbach J, Yadav S, Glaser B,
            Grzmil M, Burfeind P and Laccone F.
  TITLE     Identification and characterization of murine Brunol4, a new member
            of the elav/bruno family
  JOURNAL   Cytogenet Genome Res 97 (3-4), 254-260 (2002)
   PUBMED   12438720
  REMARK    GeneRIF: cloning and characterization
REFERENCE   8  (residues 1 to 475)
  AUTHORS   Ladd AN, Charlet N and Cooper TA.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   9  (residues 1 to 475)
  AUTHORS   Good PJ, Chen Q, Warner SJ and Herring DC.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
REFERENCE   10 (residues 1 to 475)
  AUTHORS   Yulug IG, Egan SE, See CG and Fisher EM.
  TITLE     Mapping GRB2, a signal transduction gene in the human and the mouse
  JOURNAL   Genomics 22 (2), 313-318 (1994)
   PUBMED   7806216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121094.8 and AC144938.3.
            
            On Apr 12, 2018 this sequence version replaced XP_017173287.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR6116558.125402.1,
                                           SRR1660813.160546.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 13.92 cM"
     Protein         1..475
                     /product="CUGBP Elav-like family member 4 isoform 45"
                     /note="CUG-BP- and ETR-3-like factor 4; bruno-like protein
                     4; RNA-binding protein BRUNOL-4; bruno-like 4, RNA binding
                     protein"
                     /calculated_mol_wt=50718
     Region          49..135
                     /region_name="RRM1_CELF3_4_5_6"
                     /note="RNA recognition motif 1 (RRM1) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12632"
                     /db_xref="CDD:410041"
     Site            order(55,57,59..60,63,82,84,86,95..97,99,129,131)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410041"
     Region          141..221
                     /region_name="RRM2_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12635"
                     /db_xref="CDD:410043"
     Site            order(143,145,147..148,151,170,172,174,182..184,186,216,
                     218)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410043"
     Region          406..464
                     /region_name="RRM_SF"
                     /note="RNA recognition motif (RRM) superfamily; cl17169"
                     /db_xref="CDD:450164"
     CDS             1..475
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /coded_by="NM_001362327.1:531..1958"
                     /note="isoform 45 is encoded by transcript variant 47"
                     /db_xref="GeneID:108013"
                     /db_xref="MGI:MGI:1932407"
ORIGIN      
        1 myikmatlan gqadnaslst nglgsspgsa ghmnglshsp gnpstipmkd hdaiklfigq
       61 iprnldekdl kplfeefgki yeltvlkdrf tgmhkgcafl tyceresalk aqsalheqkt
      121 lpgmnrpiqv kpadsesrge drklfvgmln kqqseddvrr lfeafgniee ctilrgpdgn
      181 skgcafvkys shaeaqaain alhgsqtmpg assslvvkfa dtdkertmrr mqqmagqmgm
      241 fnpmaipfga ygayaqalmq qqaalmasva qggylnpmaa faaaqmqqma alnmnglaaa
      301 pmtptsggst ppgitapavp sipspigvng ftglppqang qpaaeavfan gihpypaqsp
      361 taadplqqay agvqqyagpa ypaaygqisq afpqpppmip qqqregpegc nlliyhlpqe
      421 fgdaelmqmf lpfgfvsfdn pasaqtaiqa mngfqigmkr lkvqlkrpkd anrpy
//
LOCUS       NP_001409072             822 aa            linear   ROD 09-OCT-2023
DEFINITION  hypoxia-inducible factor 1-alpha isoform 6 [Mus musculus].
ACCESSION   NP_001409072 XP_017170450
VERSION     NP_001409072.1
DBSOURCE    REFSEQ: accession NM_001422143.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 822)
  AUTHORS   Xu R, Shen S, Wang D, Ye J, Song S, Wang Z and Yue Z.
  TITLE     The role of HIF-1alpha-mediated autophagy in ionizing
            radiation-induced testicular injury
  JOURNAL   J Mol Histol 54 (5), 439-451 (2023)
   PUBMED   37728670
  REMARK    GeneRIF: The role of HIF-1alpha-mediated autophagy in ionizing
            radiation-induced testicular injury.
REFERENCE   2  (residues 1 to 822)
  AUTHORS   Yang Z, Su W, Wei X, Qu S, Zhao D, Zhou J, Wang Y, Guan Q, Qin C,
            Xiang J, Zen K and Yao B.
  TITLE     HIF-1alpha drives resistance to ferroptosis in solid tumors by
            promoting lactate production and activating SLC1A1
  JOURNAL   Cell Rep 42 (8), 112945 (2023)
   PUBMED   37542723
  REMARK    GeneRIF: HIF-1alpha drives resistance to ferroptosis in solid
            tumors by promoting lactate production and activating SLC1A1.
REFERENCE   3  (residues 1 to 822)
  AUTHORS   Dery KJ, Kojima H, Kageyama S, Kadono K, Hirao H, Cheng B, Zhai Y,
            Farmer DG, Kaldas FM, Yuan X, Eltzschig HK and Kupiec-Weglinski JW.
  TITLE     Alternative splicing of CEACAM1 by hypoxia-inducible factor-1alpha
            enhances tolerance to hepatic ischemia in mice and humans
  JOURNAL   Sci Transl Med 15 (707), eadf2059 (2023)
   PUBMED   37531413
  REMARK    GeneRIF: Alternative splicing of CEACAM1 by hypoxia-inducible
            factor-1alpha enhances tolerance to hepatic ischemia in mice and
            humans.
REFERENCE   4  (residues 1 to 822)
  AUTHORS   Guo Z, Yu X, Zhao S, Zhong X, Huang D, Feng R, Li P, Fang Z, Hu Y,
            Zhang Z, Abdurahman M, Huang L, Zhao Y, Wang X, Ge J and Li H.
  TITLE     SIRT6 deficiency in endothelial cells exacerbates oxidative stress
            by enhancing HIF1alpha accumulation and H3K9 acetylation at the
            Ero1alpha promoter
  JOURNAL   Clin Transl Med 13 (8), e1377 (2023)
   PUBMED   37598403
  REMARK    GeneRIF: SIRT6 deficiency in endothelial cells exacerbates
            oxidative stress by enhancing HIF1alpha accumulation and H3K9
            acetylation at the Ero1alpha promoter.
REFERENCE   5  (residues 1 to 822)
  AUTHORS   Zhang G, Liu B, Yang Y, Xie S, Chen L, Luo H, Zhong J, Wei Y, Guo
            F, Gan J, Zhu F, Xu L, Li Q, Shen Y, Zhang H, Liu Y, Li R, Deng H
            and Yang H.
  TITLE     Mitochondrial UQCC3 controls embryonic and tumor angiogenesis by
            regulating VEGF expression
  JOURNAL   iScience 26 (8), 107370 (2023)
   PUBMED   37539028
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 822)
  AUTHORS   Li H, Ko HP and Whitlock JP.
  TITLE     Induction of phosphoglycerate kinase 1 gene expression by hypoxia.
            Roles of Arnt and HIF1alpha
  JOURNAL   J Biol Chem 271 (35), 21262-21267 (1996)
   PUBMED   8702901
REFERENCE   7  (residues 1 to 822)
  AUTHORS   Wood SM, Gleadle JM, Pugh CW, Hankinson O and Ratcliffe PJ.
  TITLE     The role of the aryl hydrocarbon receptor nuclear translocator
            (ARNT) in hypoxic induction of gene expression. Studies in
            ARNT-deficient cells
  JOURNAL   J Biol Chem 271 (25), 15117-15123 (1996)
   PUBMED   8662957
REFERENCE   8  (residues 1 to 822)
  AUTHORS   Semenza GL, Rue EA, Iyer NV, Pang MG and Kearns WG.
  TITLE     Assignment of the hypoxia-inducible factor 1alpha gene to a region
            of conserved synteny on mouse chromosome 12 and human chromosome
            14q
  JOURNAL   Genomics 34 (3), 437-439 (1996)
   PUBMED   8786149
REFERENCE   9  (residues 1 to 822)
  AUTHORS   Wenger RH, Rolfs A, Marti HH, Guenet JL and Gassmann M.
  TITLE     Nucleotide sequence, chromosomal assignment and mRNA expression of
            mouse hypoxia-inducible factor-1 alpha
  JOURNAL   Biochem Biophys Res Commun 223 (1), 54-59 (1996)
   PUBMED   8660378
REFERENCE   10 (residues 1 to 822)
  AUTHORS   Obara N and Takeda M.
  TITLE     Expression of neural cell adhesion molecule (NCAM) during the first
            molar development in the mouse
  JOURNAL   Anat Embryol (Berl) 187 (3), 209-219 (1993)
   PUBMED   8470821
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124712.5.
            
            On Jun 6, 2023 this sequence version replaced XP_017170450.1.
            
            Summary: This gene encodes the alpha subunit which, along with the
            beta subunit, forms a heterodimeric transcription factor that
            regulates the cellular and developmental response to reduced oxygen
            tension. The transcription factor has been shown to regulate genes
            involved in several biological processes, including erythropoiesis
            and angiogenesis which aid in increased delivery of oxygen to
            hypoxic regions. The transcription factor also plays a role in the
            induction of genes involved in cell proliferation and survival,
            energy metabolism, apoptosis, and glucose and iron metabolism.
            Alternative splicing results in multiple transcript variants
            encoding different isoforms. [provided by RefSeq, Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219381.212955.1,
                                           SRR9219380.13661.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..822
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 31.99 cM"
     Protein         1..822
                     /product="hypoxia-inducible factor 1-alpha isoform 6"
                     /note="hypoxia-inducible factor 1-alpha; ARNT-interacting
                     protein"
                     /calculated_mol_wt=91744
     Region          1..401
                     /region_name="Interaction with TSGA10.
                     /evidence=ECO:0000269|PubMed:16777103"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Region          1..30
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Region          13..83
                     /region_name="bHLH-PAS_HIF1a_PASD8"
                     /note="basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS)
                     domain found in hypoxia-inducible factor 1-alpha (HIF1a)
                     and similar proteins; cd19727"
                     /db_xref="CDD:381570"
     Site            order(18..19,21..23,26..27,29..30,55..56)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381570"
     Region          21..30
                     /region_name="DNA-binding.
                     /evidence=ECO:0000269|PubMed:26245371"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Site            order(32..33,35..36,39..40,43..44,55..57,60..61,64,67..68,
                     71)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:381570"
     Region          93..148
                     /region_name="PAS"
                     /note="PAS domain; smart00091"
                     /db_xref="CDD:214512"
     Region          170..191
                     /region_name="Required for heterodimer formation with
                     ARNT. /evidence=ECO:0000269|PubMed:26245371"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Site            247
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK1.
                     /evidence=ECO:0000250|UniProtKB:Q16665; propagated from
                     UniProtKB/Swiss-Prot (Q61221.3)"
     Region          254..339
                     /region_name="PAS_3"
                     /note="PAS fold; pfam08447"
                     /db_xref="CDD:430001"
     Site            order(255,259,265,278..281,307,312)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:238075"
     Site            order(275,279,287,290..291,319,321)
                     /site_type="other"
                     /note="heme pocket [chemical binding]"
                     /db_xref="CDD:238075"
     Region          380..417
                     /region_name="N-terminal VHL recognition site"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Site            402
                     /site_type="hydroxylation"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:Q16665; propagated from
                     UniProtKB/Swiss-Prot (Q61221.3)"
     Region          492..511
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Region          530..574
                     /region_name="NTAD"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Site            531
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:Q16665; propagated from
                     UniProtKB/Swiss-Prot (Q61221.3)"
     Region          550..579
                     /region_name="HIF-1"
                     /note="Hypoxia-inducible factor-1; pfam11413"
                     /db_xref="CDD:431874"
     Site            550
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by GSK3-beta.
                     /evidence=ECO:0000250|UniProtKB:Q16665; propagated from
                     UniProtKB/Swiss-Prot (Q61221.3)"
     Site            554
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by GSK3-beta.
                     /evidence=ECO:0000250|UniProtKB:Q16665; propagated from
                     UniProtKB/Swiss-Prot (Q61221.3)"
     Region          555..571
                     /region_name="C-terminal VHL recognition site"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Site            563
                     /site_type="hydroxylation"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:Q16665; propagated from
                     UniProtKB/Swiss-Prot (Q61221.3)"
     Region          575..781
                     /region_name="ID"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Site            575
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PLK3.
                     /evidence=ECO:0000250|UniProtKB:Q16665; propagated from
                     UniProtKB/Swiss-Prot (Q61221.3)"
     Region          579..670
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Site            588
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by GSK3-beta.
                     /evidence=ECO:0000250|UniProtKB:Q16665; propagated from
                     UniProtKB/Swiss-Prot (Q61221.3)"
     Site            654
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PLK3.
                     /evidence=ECO:0000250|UniProtKB:Q16665; propagated from
                     UniProtKB/Swiss-Prot (Q61221.3)"
     Region          693..720
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Site            705
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q16665; propagated from
                     UniProtKB/Swiss-Prot (Q61221.3)"
     Region          714..717
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Region          782..822
                     /region_name="CTAD"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Region          785..821
                     /region_name="HIF-1a_CTAD"
                     /note="HIF-1 alpha C terminal transactivation domain;
                     pfam08778"
                     /db_xref="CDD:430212"
     Site            799
                     /site_type="hydroxylation"
                     /note="(3S)-3-hydroxyasparagine.
                     /evidence=ECO:0000250|UniProtKB:Q16665; propagated from
                     UniProtKB/Swiss-Prot (Q61221.3)"
     CDS             1..822
                     /gene="Hif1a"
                     /gene_synonym="bHLHe78; HIF-1-alpha; HIF1-alpha;
                     HIF1alpha; MOP1"
                     /coded_by="NM_001422143.1:290..2758"
                     /note="isoform 6 is encoded by transcript variant 6"
                     /db_xref="GeneID:15251"
                     /db_xref="MGI:MGI:106918"
ORIGIN      
        1 megaggenek kkmsserrke ksrdaarsrr skesevfyel ahqlplphnv sshldkasvm
       61 rltisylrvr klldagglds edemkaqmdc fylkaldgfv mvltddgdmv yisdnvnkym
      121 gltqfeltgh svfdfthpcd heemremlth rngpvrkgke lntqrsfflr mkctltsrgr
      181 tmniksatwk vlhctghihv ydtnsnqpqc gykkppmtcl vlicepiphp snieipldsk
      241 tflsrhsldm kfsycderit elmgyepeel lgrsiyeyyh aldsdhltkt hhdmftkgqv
      301 ttgqyrmlak rggyvwvetq atviyntkns qpqcivcvny vvsgiiqhdl ifslqqtesv
      361 lkpvessdmk mtqlftkves edtsclfdkl kkepdaltll apaagdtiis ldfgsddtet
      421 edqqledvpl yndvmfpssn eklninlams plpssetpkp lrssadpaln qevalkless
      481 peslglsftm pqiqdqpasp sdgstrqssp epnspseycf dvdsdmvnvf klelveklfa
      541 edteaknpfs tqdtdldlem lapyipmddd fqlrsfdqls plesnspspp smstvtgfqq
      601 tqlqkptita tatttattde sktetkdnke dikiliasps stqvpqettt akasaysgth
      661 srtaspdrag krvieqtdka hprslnlsat lnqrntvpee elnpktiasq naqrkrkmeh
      721 dgslfqaagi gtllqqpgdc aptmslswkr vkgfisseqn gteqktiili psdlacrllg
      781 qsmdesglpq ltsydcevna piqgsrnllq geellraldq vn
//
LOCUS       NP_001263341            2266 aa            linear   ROD 09-OCT-2023
DEFINITION  fibronectin isoform f precursor [Mus musculus].
ACCESSION   NP_001263341
VERSION     NP_001263341.1
DBSOURCE    REFSEQ: accession NM_001276412.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 2266)
  AUTHORS   Huo X, Ma S, Wang C, Song L, Yao B, Zhu S, Li P, Wang L, Wu Z and
            Wang K.
  TITLE     Unravelling the role of immune cells and FN1 in the recurrence and
            therapeutic process of skull base chordoma
  JOURNAL   Clin Transl Med 13 (10), e1429 (2023)
   PUBMED   37784253
  REMARK    GeneRIF: Unravelling the role of immune cells and FN1 in the
            recurrence and therapeutic process of skull base chordoma.
REFERENCE   2  (residues 1 to 2266)
  AUTHORS   Whisler J, Shahreza S, Schlegelmilch K, Ege N, Javanmardi Y,
            Malandrino A, Agrawal A, Fantin A, Serwinski B, Azizgolshani H,
            Park C, Shone V, Demuren OO, Del Rosario A, Butty VL, Holroyd N,
            Domart MC, Hooper S, Szita N, Boyer LA, Walker-Samuel S, Djordjevic
            B, Sheridan GK, Collinson L, Calvo F, Ruhrberg C, Sahai E, Kamm R
            and Moeendarbary E.
  TITLE     Emergent mechanical control of vascular morphogenesis
  JOURNAL   Sci Adv 9 (32), eadg9781 (2023)
   PUBMED   37566656
REFERENCE   3  (residues 1 to 2266)
  AUTHORS   Jena SK, Das S, Chakraborty S and Ain R.
  TITLE     Molecular determinants of epithelial mesenchymal transition in
            mouse placenta and trophoblast stem cell
  JOURNAL   Sci Rep 13 (1), 10978 (2023)
   PUBMED   37414855
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 2266)
  AUTHORS   Hiver S, Shimizu-Mizuno N, Ikawa Y, Kajikawa E, Sai X, Nishimura H,
            Takaoka K, Nishimura O, Kuraku S, Tanaka S and Hamada H.
  TITLE     Gse1, a component of the CoREST complex, is required for placenta
            development in the mouse
  JOURNAL   Dev Biol 498, 97-105 (2023)
   PUBMED   37019373
REFERENCE   5  (residues 1 to 2266)
  AUTHORS   Ozguldez HO, Govindasamy N, Fan R, Long H, Mildner K, Zeuschner D,
            Trappmann B, Ranga A and Bedzhov I.
  TITLE     Polarity inversion reorganizes the stem cell compartment of the
            trophoblast lineage
  JOURNAL   Cell Rep 42 (4), 112313 (2023)
   PUBMED   36989113
REFERENCE   6  (residues 1 to 2266)
  AUTHORS   Saga Y, Yagi T, Ikawa Y, Sakakura T and Aizawa S.
  TITLE     Mice develop normally without tenascin
  JOURNAL   Genes Dev 6 (10), 1821-1831 (1992)
   PUBMED   1383086
REFERENCE   7  (residues 1 to 2266)
  AUTHORS   Khandjian EW, Salomon C, Leonard N, Tremblay S and Turler H.
  TITLE     Fibronectin gene expression in proliferating, quiescent, and
            SV40-infected mouse kidney cells
  JOURNAL   Exp Cell Res 202 (2), 464-470 (1992)
   PUBMED   1327855
REFERENCE   8  (residues 1 to 2266)
  AUTHORS   Vidal SM, Epstein DJ, Malo D, Weith A, Vekemans M and Gros P.
  TITLE     Identification and mapping of six microdissected genomic DNA probes
            to the proximal region of mouse chromosome 1
  JOURNAL   Genomics 14 (1), 32-37 (1992)
   PUBMED   1358796
REFERENCE   9  (residues 1 to 2266)
  AUTHORS   Malo D, Schurr E, Epstein DJ, Vekemans M, Skamene E and Gros P.
  TITLE     The host resistance locus Bcg is tightly linked to a group of
            cytoskeleton-associated protein genes that include villin and
            desmin
  JOURNAL   Genomics 10 (2), 356-364 (1991)
   PUBMED   1676979
REFERENCE   10 (residues 1 to 2266)
  AUTHORS   Wartiovaara,J., Leivo,I. and Vaheri,A.
  TITLE     Expression of the cell surface-associated glycoprotein,
            fibronectin, in the early mouse embryo
  JOURNAL   Dev Biol 69 (1), 247-257 (1979)
   PUBMED   376373
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ098561.1, AK147639.1, AK147315.1 and AC124821.5.
            
            Transcript Variant: This variant (6) lacks an in-frame exon and
            uses an alternate in-frame splice site in the coding region,
            compared to variant 1. The encoded isoform (f) is shorter than
            isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147639.1, SRR17253014.2205874.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2266
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 36.05 cM"
     Protein         1..2266
                     /product="fibronectin isoform f precursor"
                     /calculated_mol_wt=246774
     sig_peptide     1..27
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=2797
     Region          53..90
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain, approximately 40 residue
                     long with two conserved disulfide bridges. FN1 is one of
                     three types of internal repeats which combine to form
                     larger domains within fibronectin. Fibronectin, a plasma
                     protein that binds cell surfaces...; cd00061"
                     /db_xref="CDD:238018"
     Region          98..141
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          142..185
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          187..231
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          232..271
                     /region_name="fn1"
                     /note="Fibronectin type I domain; pfam00039"
                     /db_xref="CDD:425437"
     Region          308..347
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          353..401
                     /region_name="FN2"
                     /note="Fibronectin type 2 domain; smart00059"
                     /db_xref="CDD:128373"
     Site            order(364,366,371,385,392,398,400)
                     /site_type="active"
                     /note="putative gelatin-binding site [active]"
                     /db_xref="CDD:238019"
     Region          413..461
                     /region_name="FN2"
                     /note="Fibronectin type 2 domain; smart00059"
                     /db_xref="CDD:128373"
     Site            order(424,426,431,445,452,458,460)
                     /site_type="active"
                     /note="putative gelatin-binding site [active]"
                     /db_xref="CDD:238019"
     Region          470..513
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          518..560
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          561..604
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          619..688
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Region          726..797
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(797..798,800..801)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Site            order(810,871,886)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Region          811..882
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(887..888,890..891)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          907..987
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(984..985,987..988)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          997..1075
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(1073..1074,1076..1077)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1091..1158
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Region          1174..1257
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(1254..1255,1257..1258)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1267..1348
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Region          1358..1438
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Region          1450..1529
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(1525..1526,1528..1529)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1542..1622
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(1619..1620,1622..1623)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1632..1712
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Region          1722..1802
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(1799..1800,1802..1803)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1814..1893
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(1890..1891,1893..1894)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1903..1983
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Region          1999..2054
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Region          2085..2129
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          2130..2171
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          2173..2212
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain, approximately 40 residue
                     long with two conserved disulfide bridges. FN1 is one of
                     three types of internal repeats which combine to form
                     larger domains within fibronectin. Fibronectin, a plasma
                     protein that binds cell surfaces...; cd00061"
                     /db_xref="CDD:238018"
     CDS             1..2266
                     /gene="Fn1"
                     /gene_synonym="E330027I09; Fn; Fn-1"
                     /coded_by="NM_001276412.1:253..7053"
                     /note="isoform f precursor is encoded by transcript
                     variant 6"
                     /db_xref="CCDS:CCDS78610.1"
                     /db_xref="GeneID:14268"
                     /db_xref="MGI:MGI:95566"
ORIGIN      
        1 mlrgpgpgrl lllavlclgt svrcteagks krqaqqivqp qspvavsqsk pgcfdngkhy
       61 qinqqwerty lgnalvctcy ggsrgfnces kpepeetcfd kytgntykvg dtyerpkdsm
      121 iwdctcigag rgrisctian rcheggqsyk igdkwrrphe tggymleclc lgngkgewtc
      181 kpiaekcfdh aagtsyvvge twekpyqgwm mvdctclgeg ngritctsrn rcndqdtrts
      241 yrigdtwskk dnrgnllqcv ctgngrgewk cerhalqsas agsgsftdvr taiyqpqthp
      301 qpapyghcvt dsgvvysvgm qwlksqgnkq mlctclgngv scqetavtqt yggnsngepc
      361 vlpftyngrt fyscttegrq dghlwcstts nyeqdqkysf ctdhavlvqt rggnsngalc
      421 hfpflynnrn ytdctsegrr dnmkwcgttq nydadqkfgf cpmaaheeic ttnegvmyri
      481 gdqwdkqhdl ghmmrctcvg ngrgewacip ysqlrdqciv dditynvndt fhkrheeghm
      541 lnctcfgqgr grwkcdpidq cqdsetrtfy qigdswekfv hgvryqcycy grgigewhcq
      601 plqtypgttg pvqviitetp sqpnshpiqw napepshitk yilrwrpkts tgrwkeatip
      661 ghlnsytikg ltpgviyegq lisiqqyghr evtrfdftts astpvtsntv tgetapyspv
      721 vatsesvtei tassfvvswv sasdtvsgfr veyelseegd epqyldlpst atsvnipdll
      781 pgrkyivnvy qiseegkqsl ilstsqttap dappdptvdq vddtsivvrw srpqapitgy
      841 rivyspsveg sstelnlpet ansvtlsdlq pgvqynitiy aveenqestp vfiqqettgt
      901 prsdnvpppt dlqfveltdv kvtimwtppd svvsgyrvev lpvslpgehg qrlpvnrntf
      961 aeitglspgv tylfkvfavh qgresnplta qqttkldapt nlqfvnetdr tvlvtwtppr
     1021 ariagyrlta gltrggqpkq ynvgplasky plrnlqpgse ytvtlvavkg nqqspkatgv
     1081 fttlqplrsi ppyntevtet tivitwtpap rigfklgvrp sqggeaprev tsdsgsivvs
     1141 gltpgveyty tiqvlrdgqe rdapivnrvv tplspptnlh leanpdtgvl tvswersttp
     1201 ditgyrittt ptngqqgtsl eevvhadqss ctfenlnpgl eynvsvytvk ddkesapisd
     1261 tvvpavpppt dlrftnigpd tmrvtwappp sieltnllvr yspvkneedv aelsispsdn
     1321 avvltnllpg teylvsvssv yeqhesiplr grqktgldsp tgfdssdita nsftvhwvap
     1381 rapitgyiir hhaehsvgrp rqdrvppsrn sitltnlnpg teyvvsiiav ngreesppli
     1441 gqqatvsdip rdleviastp tslliswepp avsvryyrit ygetggnspv qeftvpgsks
     1501 tatinnikpg adytitlyav tgrgdspass kpvsinykte idkpsqmqvt dvqdnsisvr
     1561 wlpstspvtg yrvtttpkng lgpsktktas pdqtemtieg lqptveyvvs vyaqnrnges
     1621 qplvqtavtn idrpkglaft dvdvdsikia wespqgqvsr yrvtyssped girelfpapd
     1681 geddtaelqg lrpgseytvs vvalhddmes qpligiqsta ipaptnlkfs qvtptsftaq
     1741 wiapsvqltg yrvrvnpkek tgpmkeinls pdsssvivsg lmvatkyevs vyalkdtlts
     1801 rpaqgvittl envspprrar vtdatettit iswrtkteti tgfqvdaipa ngqtpvqrsi
     1861 spdvrsytit glqpgtdyki hlytlndnar sspviidast aidapsnlrf ltttpnsllv
     1921 swqaprarit gyiikyekpg spprevvprp rpgvteatit glepgteyti yvialknnqk
     1981 sepligrkkt gqealsqtti swtpfqesse yiiscqpvgt deeplqfqvp gtstsatltg
     2041 ltrgvtynii vealqnqrrh kvreevvtvg navseglnqp tddscfdpyt vshyaigeew
     2101 erlsdagfkl tcqclgfgsg hfrcdsskwc hdngvnykig ekwdrqgeng qrmsctclgn
     2161 gkgefkcdph eatcyddgkt yhvgeqwqke ylgaicsctc fggqrgwrcd ncrrpgaaep
     2221 spdgttghty nqytqrynqr tntnvncpie cfmpldvqad rddsre
//
LOCUS       NP_001276391             750 aa            linear   ROD 09-OCT-2023
DEFINITION  neprilysin [Mus musculus].
ACCESSION   NP_001276391 XP_006501160
VERSION     NP_001276391.1
DBSOURCE    REFSEQ: accession NM_001289462.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 750)
  AUTHORS   Esser N, Mongovin SM, Mundinger TO, Barrow BM and Zraika S.
  TITLE     Neprilysin deficiency reduces hepatic gluconeogenesis in high
            fat-fed mice
  JOURNAL   Peptides 168, 171076 (2023)
   PUBMED   37572792
  REMARK    GeneRIF: Neprilysin deficiency reduces hepatic gluconeogenesis in
            high fat-fed mice.
REFERENCE   2  (residues 1 to 750)
  AUTHORS   Esser N, Mundinger TO, Barrow BM and Zraika S.
  TITLE     Acute Inhibition of Intestinal Neprilysin Enhances Insulin
            Secretion via GLP-1 Receptor Signaling in Male Mice
  JOURNAL   Endocrinology 164 (5) (2023)
   PUBMED   36964914
  REMARK    GeneRIF: Acute Inhibition of Intestinal Neprilysin Enhances Insulin
            Secretion via GLP-1 Receptor Signaling in Male Mice.
REFERENCE   3  (residues 1 to 750)
  AUTHORS   Ortiz C, Klein S, Reul WH, Magdaleno F, Groschl S, Dietrich P,
            Schierwagen R, Uschner FE, Torres S, Hieber C, Meier C, Kraus N,
            Tyc O, Brol M, Zeuzem S, Welsch C, Poglitsch M, Hellerbrand C,
            Alfonso-Prieto M, Mira F, Keller UAD, Tetzner A, Moore A, Walther T
            and Trebicka J.
  TITLE     Neprilysin-dependent neuropeptide Y cleavage in the liver promotes
            fibrosis by blocking NPY-receptor 1
  JOURNAL   Cell Rep 42 (2), 112059 (2023)
   PUBMED   36729833
  REMARK    GeneRIF: Neprilysin-dependent neuropeptide Y cleavage in the liver
            promotes fibrosis by blocking NPY-receptor 1.
REFERENCE   4  (residues 1 to 750)
  AUTHORS   Chen Y and Burnett JC Jr.
  TITLE     Biochemistry, Therapeutics, and Biomarker Implications of
            Neprilysin in Cardiorenal Disease
  JOURNAL   Clin Chem 63 (1), 108-115 (2017)
   PUBMED   28062615
  REMARK    Review article
REFERENCE   5  (residues 1 to 750)
  AUTHORS   Bayes-Genis A, Barallat J and Richards AM.
  TITLE     A Test in Context: Neprilysin: Function, Inhibition, and Biomarker
  JOURNAL   J Am Coll Cardiol 68 (6), 639-653 (2016)
   PUBMED   27491909
  REMARK    Review article
REFERENCE   6  (residues 1 to 750)
  AUTHORS   Turner AJ and Nalivaeva NN.
  TITLE     Proteinase dysbalance in pathology: the neprilysin (NEP) and
            angiotensin-converting enzyme (ACE) families
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 52 (4), 40-48 (2006)
   PUBMED   17543197
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   7  (residues 1 to 750)
  AUTHORS   Weil M, Itin A and Keshet E.
  TITLE     A role for mesenchyme-derived tachykinins in tooth and mammary
            gland morphogenesis
  JOURNAL   Development 121 (8), 2419-2428 (1995)
   PUBMED   7545574
REFERENCE   8  (residues 1 to 750)
  AUTHORS   Kalled SL, Siva N, Stein H and Reinherz EL.
  TITLE     The distribution of CD10 (NEP 24.11, CALLA) in humans and mice is
            similar in non-lymphoid organs but differs within the hematopoietic
            system: absence on murine T and B lymphoid progenitors
  JOURNAL   Eur J Immunol 25 (3), 677-687 (1995)
   PUBMED   7705396
REFERENCE   9  (residues 1 to 750)
  AUTHORS   Watson ML, Rao JK, Gilkeson GS, Ruiz P, Eicher EM, Pisetsky DS,
            Matsuzawa A, Rochelle JM and Seldin MF.
  TITLE     Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis
            gene to disease manifestations and renal disease-modifying loci
  JOURNAL   J Exp Med 176 (6), 1645-1656 (1992)
   PUBMED   1460423
REFERENCE   10 (residues 1 to 750)
  AUTHORS   Chen CY, Salles G, Seldin MF, Kister AE, Reinherz EL and Shipp MA.
  TITLE     Murine common acute lymphoblastic leukemia antigen (CD10 neutral
            endopeptidase 24.11). Molecular characterization, chromosomal
            localization, and modeling of the active site
  JOURNAL   J Immunol 148 (9), 2817-2825 (1992)
   PUBMED   1374101
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY145991.1, AK076908.1, AK031446.1 and AC121840.3.
            
            On Jan 22, 2014 this sequence version replaced XP_006501160.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK076908.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..750
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 29.97 cM"
     Protein         1..750
                     /product="neprilysin"
                     /EC_number="3.4.24.11"
                     /note="common acute lymphoblastic leukemia antigen;
                     enkephalinase; atriopeptidase; neutral endopeptidase
                     24.11; skin fibroblast elastase"
                     /calculated_mol_wt=85571
     Site            4
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61391.3)"
     Site            6
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61391.3)"
     Region          16..23
                     /region_name="Stop-transfer sequence.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61391.3)"
     Site            29..51
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61391.3)"
     Region          77..748
                     /region_name="M13"
                     /note="Peptidase family M13 includes neprilysin and
                     endothelin-converting enzyme I; cd08662"
                     /db_xref="CDD:341056"
     Site            order(107,537,542..545,564,580..581,584..585,588,647,690,
                     693..694,711..712,718)
                     /site_type="active"
                     /db_xref="CDD:341056"
     Site            145
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19349973; propagated from
                     UniProtKB/Swiss-Prot (Q61391.3)"
     Site            211
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61391.3)"
     Site            285
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19349973; propagated from
                     UniProtKB/Swiss-Prot (Q61391.3)"
     Site            311
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19349973; propagated from
                     UniProtKB/Swiss-Prot (Q61391.3)"
     Site            325
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000250|UniProtKB:P08473; propagated from
                     UniProtKB/Swiss-Prot (Q61391.3)"
     Site            628
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000250|UniProtKB:P08473; propagated from
                     UniProtKB/Swiss-Prot (Q61391.3)"
     CDS             1..750
                     /gene="Mme"
                     /gene_synonym="6030454K05Rik; CALLA; CD10; NEP; SFE"
                     /coded_by="NM_001289462.1:455..2707"
                     /db_xref="CCDS:CCDS17381.1"
                     /db_xref="GeneID:17380"
                     /db_xref="MGI:MGI:97004"
ORIGIN      
        1 mgrsesqmdi tdinapkpkk kqrwtpleis lsvlvlllti iavtmialya tyddgickss
       61 dciksaarli qnmdasvepc tdffkyacgg wlkrnvipet ssrysnfdil rdelevilkd
      121 vlqepktedi vavqkaktly rscinesaid srggqpllkl lpdiygwpva sdnwdqtygt
      181 swtaeksiaq lnskygkkvl inffvgtddk nstqhiihfd qprlglpsrd yyectgiyke
      241 actayvdfmi svarlirqeq slpidenqls lemnkvmele keianattkp edrndpmlly
      301 nkmtlaklqn nfslevngks fswsnftnei mstvniniqn eeevvvyape yltklkpilt
      361 kysprdlqnl mswrfimdlv sslsrnykes rnafrkalyg ttsetatwrr canyvngnme
      421 navgrlyvea afageskhvv edliaqirev fiqtlddltw mdaetkkkae ekalaikeri
      481 gypddiisne nklnneylel nyredeyfen iiqnlkfsqs kqlkklrekv dkdewisgaa
      541 vvnafyssgr nqivfpagil qppffsaqqs nslnyggigm vigheithgf ddngrnfnkd
      601 gdlvdwwtqq sannfkdqsq cmvyqygnfs wdlaggqhln gintlgenia dnggigqayr
      661 ayqnyvkkng eekllpgldl nhkqlfflnf aqvwcgtyrp eyavnsiktd vhspgnfrii
      721 gtlqnsaefa dafhcrknsy mnperkcrvw
//
LOCUS       NP_001263338            2361 aa            linear   ROD 09-OCT-2023
DEFINITION  fibronectin isoform c precursor [Mus musculus].
ACCESSION   NP_001263338
VERSION     NP_001263338.1
DBSOURCE    REFSEQ: accession NM_001276409.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 2361)
  AUTHORS   Huo X, Ma S, Wang C, Song L, Yao B, Zhu S, Li P, Wang L, Wu Z and
            Wang K.
  TITLE     Unravelling the role of immune cells and FN1 in the recurrence and
            therapeutic process of skull base chordoma
  JOURNAL   Clin Transl Med 13 (10), e1429 (2023)
   PUBMED   37784253
  REMARK    GeneRIF: Unravelling the role of immune cells and FN1 in the
            recurrence and therapeutic process of skull base chordoma.
REFERENCE   2  (residues 1 to 2361)
  AUTHORS   Whisler J, Shahreza S, Schlegelmilch K, Ege N, Javanmardi Y,
            Malandrino A, Agrawal A, Fantin A, Serwinski B, Azizgolshani H,
            Park C, Shone V, Demuren OO, Del Rosario A, Butty VL, Holroyd N,
            Domart MC, Hooper S, Szita N, Boyer LA, Walker-Samuel S, Djordjevic
            B, Sheridan GK, Collinson L, Calvo F, Ruhrberg C, Sahai E, Kamm R
            and Moeendarbary E.
  TITLE     Emergent mechanical control of vascular morphogenesis
  JOURNAL   Sci Adv 9 (32), eadg9781 (2023)
   PUBMED   37566656
REFERENCE   3  (residues 1 to 2361)
  AUTHORS   Jena SK, Das S, Chakraborty S and Ain R.
  TITLE     Molecular determinants of epithelial mesenchymal transition in
            mouse placenta and trophoblast stem cell
  JOURNAL   Sci Rep 13 (1), 10978 (2023)
   PUBMED   37414855
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 2361)
  AUTHORS   Hiver S, Shimizu-Mizuno N, Ikawa Y, Kajikawa E, Sai X, Nishimura H,
            Takaoka K, Nishimura O, Kuraku S, Tanaka S and Hamada H.
  TITLE     Gse1, a component of the CoREST complex, is required for placenta
            development in the mouse
  JOURNAL   Dev Biol 498, 97-105 (2023)
   PUBMED   37019373
REFERENCE   5  (residues 1 to 2361)
  AUTHORS   Ozguldez HO, Govindasamy N, Fan R, Long H, Mildner K, Zeuschner D,
            Trappmann B, Ranga A and Bedzhov I.
  TITLE     Polarity inversion reorganizes the stem cell compartment of the
            trophoblast lineage
  JOURNAL   Cell Rep 42 (4), 112313 (2023)
   PUBMED   36989113
REFERENCE   6  (residues 1 to 2361)
  AUTHORS   Saga Y, Yagi T, Ikawa Y, Sakakura T and Aizawa S.
  TITLE     Mice develop normally without tenascin
  JOURNAL   Genes Dev 6 (10), 1821-1831 (1992)
   PUBMED   1383086
REFERENCE   7  (residues 1 to 2361)
  AUTHORS   Khandjian EW, Salomon C, Leonard N, Tremblay S and Turler H.
  TITLE     Fibronectin gene expression in proliferating, quiescent, and
            SV40-infected mouse kidney cells
  JOURNAL   Exp Cell Res 202 (2), 464-470 (1992)
   PUBMED   1327855
REFERENCE   8  (residues 1 to 2361)
  AUTHORS   Vidal SM, Epstein DJ, Malo D, Weith A, Vekemans M and Gros P.
  TITLE     Identification and mapping of six microdissected genomic DNA probes
            to the proximal region of mouse chromosome 1
  JOURNAL   Genomics 14 (1), 32-37 (1992)
   PUBMED   1358796
REFERENCE   9  (residues 1 to 2361)
  AUTHORS   Malo D, Schurr E, Epstein DJ, Vekemans M, Skamene E and Gros P.
  TITLE     The host resistance locus Bcg is tightly linked to a group of
            cytoskeleton-associated protein genes that include villin and
            desmin
  JOURNAL   Genomics 10 (2), 356-364 (1991)
   PUBMED   1676979
REFERENCE   10 (residues 1 to 2361)
  AUTHORS   Wartiovaara,J., Leivo,I. and Vaheri,A.
  TITLE     Expression of the cell surface-associated glycoprotein,
            fibronectin, in the early mouse embryo
  JOURNAL   Dev Biol 69 (1), 247-257 (1979)
   PUBMED   376373
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ098561.1, AK147315.1 and AC124821.5.
            
            Transcript Variant: This variant (3) lacks an in-frame exon and
            uses an alternate in-frame splice site in the coding region,
            compared to variant 1. The encoded isoform (c) is shorter than
            isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147315.1, SRR17253011.3494721.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2361
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 36.05 cM"
     Protein         1..2361
                     /product="fibronectin isoform c precursor"
                     /calculated_mol_wt=257350
     sig_peptide     1..27
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=2797
     Region          53..90
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain, approximately 40 residue
                     long with two conserved disulfide bridges. FN1 is one of
                     three types of internal repeats which combine to form
                     larger domains within fibronectin. Fibronectin, a plasma
                     protein that binds cell surfaces...; cd00061"
                     /db_xref="CDD:238018"
     Region          98..141
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          142..185
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          187..231
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          232..271
                     /region_name="fn1"
                     /note="Fibronectin type I domain; pfam00039"
                     /db_xref="CDD:425437"
     Region          308..347
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          353..401
                     /region_name="FN2"
                     /note="Fibronectin type 2 domain; smart00059"
                     /db_xref="CDD:128373"
     Site            order(364,366,371,385,392,398,400)
                     /site_type="active"
                     /note="putative gelatin-binding site [active]"
                     /db_xref="CDD:238019"
     Region          413..461
                     /region_name="FN2"
                     /note="Fibronectin type 2 domain; smart00059"
                     /db_xref="CDD:128373"
     Site            order(424,426,431,445,452,458,460)
                     /site_type="active"
                     /note="putative gelatin-binding site [active]"
                     /db_xref="CDD:238019"
     Region          470..513
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          518..560
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          561..604
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          619..688
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Region          726..797
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(797..798,800..801)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Site            order(810,871,886)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Region          811..882
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(887..888,890..891)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          907..987
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(984..985,987..988)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          997..1075
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(1073..1074,1076..1077)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1091..1158
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Region          1174..1257
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(1254..1255,1257..1258)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1267..1348
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Region          1358..1438
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Region          1450..1529
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(1525..1526,1528..1529)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1542..1622
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(1619..1620,1622..1623)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1632..1712
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Region          1722..1802
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(1799..1800,1802..1803)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1814..1893
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(1890..1891,1893..1894)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1903..1983
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Region          2094..2149
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Region          2180..2224
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          2225..2266
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          2268..2307
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain, approximately 40 residue
                     long with two conserved disulfide bridges. FN1 is one of
                     three types of internal repeats which combine to form
                     larger domains within fibronectin. Fibronectin, a plasma
                     protein that binds cell surfaces...; cd00061"
                     /db_xref="CDD:238018"
     CDS             1..2361
                     /gene="Fn1"
                     /gene_synonym="E330027I09; Fn; Fn-1"
                     /coded_by="NM_001276409.1:253..7338"
                     /note="isoform c precursor is encoded by transcript
                     variant 3"
                     /db_xref="CCDS:CCDS78611.1"
                     /db_xref="GeneID:14268"
                     /db_xref="MGI:MGI:95566"
ORIGIN      
        1 mlrgpgpgrl lllavlclgt svrcteagks krqaqqivqp qspvavsqsk pgcfdngkhy
       61 qinqqwerty lgnalvctcy ggsrgfnces kpepeetcfd kytgntykvg dtyerpkdsm
      121 iwdctcigag rgrisctian rcheggqsyk igdkwrrphe tggymleclc lgngkgewtc
      181 kpiaekcfdh aagtsyvvge twekpyqgwm mvdctclgeg ngritctsrn rcndqdtrts
      241 yrigdtwskk dnrgnllqcv ctgngrgewk cerhalqsas agsgsftdvr taiyqpqthp
      301 qpapyghcvt dsgvvysvgm qwlksqgnkq mlctclgngv scqetavtqt yggnsngepc
      361 vlpftyngrt fyscttegrq dghlwcstts nyeqdqkysf ctdhavlvqt rggnsngalc
      421 hfpflynnrn ytdctsegrr dnmkwcgttq nydadqkfgf cpmaaheeic ttnegvmyri
      481 gdqwdkqhdl ghmmrctcvg ngrgewacip ysqlrdqciv dditynvndt fhkrheeghm
      541 lnctcfgqgr grwkcdpidq cqdsetrtfy qigdswekfv hgvryqcycy grgigewhcq
      601 plqtypgttg pvqviitetp sqpnshpiqw napepshitk yilrwrpkts tgrwkeatip
      661 ghlnsytikg ltpgviyegq lisiqqyghr evtrfdftts astpvtsntv tgetapyspv
      721 vatsesvtei tassfvvswv sasdtvsgfr veyelseegd epqyldlpst atsvnipdll
      781 pgrkyivnvy qiseegkqsl ilstsqttap dappdptvdq vddtsivvrw srpqapitgy
      841 rivyspsveg sstelnlpet ansvtlsdlq pgvqynitiy aveenqestp vfiqqettgt
      901 prsdnvpppt dlqfveltdv kvtimwtppd svvsgyrvev lpvslpgehg qrlpvnrntf
      961 aeitglspgv tylfkvfavh qgresnplta qqttkldapt nlqfvnetdr tvlvtwtppr
     1021 ariagyrlta gltrggqpkq ynvgplasky plrnlqpgse ytvtlvavkg nqqspkatgv
     1081 fttlqplrsi ppyntevtet tivitwtpap rigfklgvrp sqggeaprev tsdsgsivvs
     1141 gltpgveyty tiqvlrdgqe rdapivnrvv tplspptnlh leanpdtgvl tvswersttp
     1201 ditgyrittt ptngqqgtsl eevvhadqss ctfenlnpgl eynvsvytvk ddkesapisd
     1261 tvvpavpppt dlrftnigpd tmrvtwappp sieltnllvr yspvkneedv aelsispsdn
     1321 avvltnllpg teylvsvssv yeqhesiplr grqktgldsp tgfdssdita nsftvhwvap
     1381 rapitgyiir hhaehsvgrp rqdrvppsrn sitltnlnpg teyvvsiiav ngreesppli
     1441 gqqatvsdip rdleviastp tslliswepp avsvryyrit ygetggnspv qeftvpgsks
     1501 tatinnikpg adytitlyav tgrgdspass kpvsinykte idkpsqmqvt dvqdnsisvr
     1561 wlpstspvtg yrvtttpkng lgpsktktas pdqtemtieg lqptveyvvs vyaqnrnges
     1621 qplvqtavtn idrpkglaft dvdvdsikia wespqgqvsr yrvtyssped girelfpapd
     1681 geddtaelqg lrpgseytvs vvalhddmes qpligiqsta ipaptnlkfs qvtptsftaq
     1741 wiapsvqltg yrvrvnpkek tgpmkeinls pdsssvivsg lmvatkyevs vyalkdtlts
     1801 rpaqgvittl envspprrar vtdatettit iswrtkteti tgfqvdaipa ngqtpvqrsi
     1861 spdvrsytit glqpgtdyki hlytlndnar sspviidast aidapsnlrf ltttpnsllv
     1921 swqaprarit gyiikyekpg spprevvprp rpgvteatit glepgteyti yvialknnqk
     1981 sepligrkkt vqktpfitnp gydtengiql pgtthqqpsv gqqmifeehg frrttpptaa
     2041 tpvrlrprpy lpnvdeevqi ghvprgdvdy hlyphvpgln pnastgqeal sqttiswtpf
     2101 qesseyiisc qpvgtdeepl qfqvpgtsts atltgltrgv tyniivealq nqrrhkvree
     2161 vvtvgnavse glnqptddsc fdpytvshya igeewerlsd agfkltcqcl gfgsghfrcd
     2221 sskwchdngv nykigekwdr qgengqrmsc tclgngkgef kcdpheatcy ddgktyhvge
     2281 qwqkeylgai csctcfggqr gwrcdncrrp gaaepspdgt tghtynqytq rynqrtntnv
     2341 ncpiecfmpl dvqadrddsr e
//
LOCUS       NP_001192242             755 aa            linear   ROD 09-OCT-2023
DEFINITION  signal transducer and activator of transcription 1 isoform 1 [Mus
            musculus].
ACCESSION   NP_001192242
VERSION     NP_001192242.1
DBSOURCE    REFSEQ: accession NM_001205313.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 755)
  AUTHORS   Kong P, Yang M, Wang Y, Yu KN, Wu L and Han W.
  TITLE     Ferroptosis triggered by STAT1- IRF1-ACSL4 pathway was involved in
            radiation-induced intestinal injury
  JOURNAL   Redox Biol 66, 102857 (2023)
   PUBMED   37611494
  REMARK    GeneRIF: Ferroptosis triggered by STAT1- IRF1-ACSL4 pathway was
            involved in radiation-induced intestinal injury.
REFERENCE   2  (residues 1 to 755)
  AUTHORS   Clark DN, O'Neil SM, Xu L, Steppe JT, Savage JT, Raghunathan K and
            Filiano AJ.
  TITLE     Prolonged STAT1 activation in neurons drives a pathological
            transcriptional response
  JOURNAL   J Neuroimmunol 382, 578168 (2023)
   PUBMED   37556887
  REMARK    GeneRIF: Prolonged STAT1 activation in neurons drives a
            pathological transcriptional response.
REFERENCE   3  (residues 1 to 755)
  AUTHORS   Imitola J, Hollingsworth EW, Watanabe F, Olah M, Elyaman W,
            Starossom S, Kivisakk P and Khoury SJ.
  TITLE     Stat1 is an inducible transcriptional repressor of neural stem
            cells self-renewal program during neuroinflammation
  JOURNAL   Front Cell Neurosci 17, 1156802 (2023)
   PUBMED   37663126
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 755)
  AUTHORS   Han W, Pu H, Li S, Liu Y, Zhao Y, Xu M, Chen C, Wu Y, Yang T, Ye Q,
            Wang H, Stetler RA, Chen J and Shi Y.
  TITLE     Targeted ablation of signal transducer and activator of
            transduction 1 alleviates inflammation by microglia/macrophages and
            promotes long-term recovery after ischemic stroke
  JOURNAL   J Neuroinflammation 20 (1), 178 (2023)
   PUBMED   37516843
  REMARK    GeneRIF: Targeted ablation of signal transducer and activator of
            transduction 1 alleviates inflammation by microglia/macrophages and
            promotes long-term recovery after ischemic stroke.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 755)
  AUTHORS   Largent AD, Lambert K, Chiang K, Shumlak N, Liggitt D, Oukka M,
            Torgerson TR, Buckner JH, Allenspach EJ, Rawlings DJ and Jackson
            SW.
  TITLE     Dysregulated IFN-gamma signals promote autoimmunity in STAT1
            gain-of-function syndrome
  JOURNAL   Sci Transl Med 15 (703), eade7028 (2023)
   PUBMED   37406138
REFERENCE   6  (residues 1 to 755)
  AUTHORS   Novak U, Harpur AG, Paradiso L, Kanagasundaram V, Jaworowski A,
            Wilks AF and Hamilton JA.
  TITLE     Colony-stimulating factor 1-induced STAT1 and STAT3 activation is
            accompanied by phosphorylation of Tyk2 in macrophages and Tyk2 and
            JAK1 in fibroblasts
  JOURNAL   Blood 86 (8), 2948-2956 (1995)
   PUBMED   7579387
REFERENCE   7  (residues 1 to 755)
  AUTHORS   Finidori J and Kelly PA.
  TITLE     Cytokine receptor signalling through two novel families of
            transducer molecules: Janus kinases, and signal transducers and
            activators of transcription
  JOURNAL   J Endocrinol 147 (1), 11-23 (1995)
   PUBMED   7490523
  REMARK    Review article
REFERENCE   8  (residues 1 to 755)
  AUTHORS   Harroch S, Gothelf Y, Revel M and Chebath J.
  TITLE     5' upstream sequences of MyD88, an IL-6 primary response gene in M1
            cells: detection of functional IRF-1 and Stat factors binding sites
  JOURNAL   Nucleic Acids Res 23 (17), 3539-3546 (1995)
   PUBMED   7567467
REFERENCE   9  (residues 1 to 755)
  AUTHORS   Matsuda T and Hirano T.
  TITLE     Association of p72 tyrosine kinase with Stat factors and its
            activation by interleukin-3, interleukin-6, and granulocyte
            colony-stimulating factor
  JOURNAL   Blood 83 (12), 3457-3461 (1994)
   PUBMED   7515712
REFERENCE   10 (residues 1 to 755)
  AUTHORS   Zhong Z, Wen Z and Darnell JE Jr.
  TITLE     Stat3 and Stat4: members of the family of signal transducers and
            activators of transcription
  JOURNAL   Proc Natl Acad Sci U S A 91 (11), 4806-4810 (1994)
   PUBMED   7545930
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK046517.1, AC123752.8, BC042551.1 and BX513160.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK046517.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..755
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 26.81 cM"
     Protein         1..755
                     /product="signal transducer and activator of transcription
                     1 isoform 1"
                     /calculated_mol_wt=87902
     Region          2..121
                     /region_name="STAT_int"
                     /note="STAT protein, protein interaction domain;
                     smart00964"
                     /db_xref="CDD:214942"
     Region          138..313
                     /region_name="STAT1_CCD"
                     /note="Coiled-coil domain of Signal Transducer and
                     Activator of Transcription 1 (STAT1); cd16851"
                     /db_xref="CDD:341076"
     Site            order(164..165,168..169,172,175..176,179,232,236,239..241,
                     243..244,256..257,259..260,263..264,267,271,274,306,
                     309..311)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:341076"
     Site            order(239..241,243..244,256..257,260,263..264,267,271,274,
                     302,306,309..310)
                     /site_type="other"
                     /note="CCD-DBD interface [polypeptide binding]"
                     /db_xref="CDD:341076"
     Region          317..483
                     /region_name="STAT1_DBD"
                     /note="DNA-binding domain of Signal Transducer and
                     Activator of Transcription 1 (STAT1); cd16845"
                     /db_xref="CDD:341083"
     Site            order(336,340,378,411,413,426..427,465..466,469)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:341083"
     Region          563..713
                     /region_name="SH2_STAT1"
                     /note="Src homology 2 (SH2) domain found in signal
                     transducer and activator of transcription (STAT) 1
                     proteins; cd10372"
                     /db_xref="CDD:198235"
     Site            order(590,608,636,638)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198235"
     Site            order(637,653)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198235"
     Site            order(647..648,712)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:198235"
     Region          721..745
                     /region_name="STAT1_TAZ2bind"
                     /note="STAT1 TAZ2 binding domain; pfam12162"
                     /db_xref="CDD:432372"
     CDS             1..755
                     /gene="Stat1"
                     /gene_synonym="2010005J02Rik"
                     /coded_by="NM_001205313.1:300..2567"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS78581.1"
                     /db_xref="GeneID:20846"
                     /db_xref="MGI:MGI:103063"
ORIGIN      
        1 msqwfelqql dskfleqvhq lyddsfpmei rqylaqwlek qdwehaaydv sfatirfhdl
       61 lsqlddqysr fslennfllq hnirkskrnl qdnfqedpvq msmiiynclk eerkilenaq
      121 rfnqaqegni qntvmldkqk eldskvrnvk dqvmcieqei ktleelqdey dfkcktsqnr
      181 egeangvaks dqkqeqlllh kmflmldnkr keiihkirel lnsieltqnt lindelvewk
      241 rrqqsacigg ppnacldqlq swftivaetl qqirqqlkkl eeleqkftye pdpitknkqv
      301 lsdrtfllfq qliqssfvve rqpcmpthpq rplvlktgvq ftvklrllvk lqelnynlkv
      361 kvsfdkdvne kntvkgfrkf nilgthtkvm nmeestngsl aaefrhlqlk eqknagnrtn
      421 egplivteel hslsfetqlc qpglvidlev fvpfqttslp vvvisnvsql psgwasilwy
      481 nmlvteprnl sfflnppcaw wsqlsevlsw qfssvtkrgl nadqlsmlge kllgpnagpd
      541 glipwtrfck enindknfsf wpwidtilel ikkhllclwn dgcimgfisk ererallkdq
      601 qpgtfllrfs essregaitf twversqngg epdfhavepy tkkelsavtf pdiirnykvm
      661 aaenipenpl kylypnidkd hafgkyysrp keapepmeld dpkrtgyikt elisvsevhp
      721 srlqttdnll pmspeefdem srivgpefds mmstv
//
LOCUS       NP_001368856             657 aa            linear   ROD 09-OCT-2023
DEFINITION  broad substrate specificity ATP-binding cassette transporter ABCG2
            [Mus musculus].
ACCESSION   NP_001368856 XP_006506211
VERSION     NP_001368856.1
DBSOURCE    REFSEQ: accession NM_001381927.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 657)
  AUTHORS   Notsu T, Kurata Y, Ninomiya H, Taufiq F, Komatsu K, Miake J, Sawano
            T, Tsuneto M, Shirayoshi Y and Hisatome I.
  TITLE     Inhibition of the uric acid efflux transporter ABCG2 enhances
            stimulating effect of soluble uric acid on IL-1beta production in
            murine macrophage-like J774.1 cells
  JOURNAL   Hypertens Res 46 (10), 2368-2377 (2023)
   PUBMED   37592041
  REMARK    GeneRIF: Inhibition of the uric acid efflux transporter ABCG2
            enhances stimulating effect of soluble uric acid on IL-1beta
            production in murine macrophage-like J774.1 cells.
REFERENCE   2  (residues 1 to 657)
  AUTHORS   Harby SA, Khalil NA, El-Sayed NS, Thabet EH, Saleh SR and Fathelbab
            MH.
  TITLE     Implications of BCRP modulation on PTZ-induced seizures in mice:
            Role of ko143 and metformin as adjuvants to lamotrigine
  JOURNAL   Naunyn Schmiedebergs Arch Pharmacol 396 (10), 2627-2636 (2023)
   PUBMED   37067582
  REMARK    GeneRIF: Implications of BCRP modulation on PTZ-induced seizures in
            mice: Role of ko143 and metformin as adjuvants to lamotrigine.
REFERENCE   3  (residues 1 to 657)
  AUTHORS   Blanco-Paniagua E, Alvarez-Fernandez L, Rodriguez-Alonso A,
            Millan-Garcia A, Alvarez AI and Merino G.
  TITLE     Role of the Abcg2 Transporter in Secretion into Milk of the
            Anthelmintic Clorsulon: Interaction with Ivermectin
  JOURNAL   Antimicrob Agents Chemother 67 (5), e0009523 (2023)
   PUBMED   37078871
  REMARK    GeneRIF: Role of the Abcg2 Transporter in Secretion into Milk of
            the Anthelmintic Clorsulon: Interaction with Ivermectin.
REFERENCE   4  (residues 1 to 657)
  AUTHORS   Wu C, Xiao Y, Wu C, Xie D, Luo M, Yao D, Chen M and Lu D.
  TITLE     Regulation of BCRP expression and sulfasalazine pharmacokinetics by
            the nuclear receptor REV-ERBalpha
  JOURNAL   Xenobiotica 53 (3), 215-222 (2023)
   PUBMED   37039301
  REMARK    GeneRIF: Regulation of BCRP expression and sulfasalazine
            pharmacokinetics by the nuclear receptor REV-ERBalpha.
REFERENCE   5  (residues 1 to 657)
  AUTHORS   Alvarez-Fernandez L, Gomez-Gomez A, Haro N, Garcia-Lino AM, Alvarez
            AI, Pozo OJ and Merino G.
  TITLE     ABCG2 transporter plays a key role in the biodistribution of
            melatonin and its main metabolites
  JOURNAL   J Pineal Res 74 (2), e12849 (2023)
   PUBMED   36562106
  REMARK    GeneRIF: ABCG2 transporter plays a key role in the biodistribution
            of melatonin and its main metabolites.
REFERENCE   6  (residues 1 to 657)
  AUTHORS   Geschwind DH, Ou J, Easterday MC, Dougherty JD, Jackson RL, Chen Z,
            Antoine H, Terskikh A, Weissman IL, Nelson SF and Kornblum HI.
  TITLE     A genetic analysis of neural progenitor differentiation
  JOURNAL   Neuron 29 (2), 325-339 (2001)
   PUBMED   11239426
REFERENCE   7  (residues 1 to 657)
  AUTHORS   Jonker JW, Smit JW, Brinkhuis RF, Maliepaard M, Beijnen JH,
            Schellens JH and Schinkel AH.
  TITLE     Role of breast cancer resistance protein in the bioavailability and
            fetal penetration of topotecan
  JOURNAL   J Natl Cancer Inst 92 (20), 1651-1656 (2000)
   PUBMED   11036110
REFERENCE   8  (residues 1 to 657)
  AUTHORS   Schriml LM and Dean M.
  TITLE     Identification of 18 mouse ABC genes and characterization of the
            ABC superfamily in Mus musculus
  JOURNAL   Genomics 64 (1), 24-31 (2000)
   PUBMED   10708515
REFERENCE   9  (residues 1 to 657)
  AUTHORS   Allen JD, Brinkhuis RF, Wijnholds J and Schinkel AH.
  TITLE     The mouse Bcrp1/Mxr/Abcp gene: amplification and overexpression in
            cell lines selected for resistance to topotecan, mitoxantrone, or
            doxorubicin
  JOURNAL   Cancer Res 59 (17), 4237-4241 (1999)
   PUBMED   10485464
REFERENCE   10 (residues 1 to 657)
  AUTHORS   Allikmets R, Schriml LM, Hutchinson A, Romano-Spica V and Dean M.
  TITLE     A human placenta-specific ATP-binding cassette gene (ABCP) on
            chromosome 4q22 that is involved in multidrug resistance
  JOURNAL   Cancer Res 58 (23), 5337-5339 (1998)
   PUBMED   9850061
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121859.2.
            
            On Apr 20, 2020 this sequence version replaced XP_006506211.1.
            
            Summary: The membrane-associated protein encoded by this gene is
            included in the superfamily of ATP-binding cassette (ABC)
            transporters. ABC proteins transport various molecules across
            extra- and intra-cellular membranes. ABC genes are divided into
            seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,
            White). This protein is a member of the White subfamily.
            Alternatively referred to as a breast cancer resistance protein,
            the human protein functions as a xenobiotic transporter which may
            play a major role in multi-drug resistance. This protein likely
            serves as a cellular defense mechanism in response to mitoxantrone
            and anthracycline exposure. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189679.67132.1,
                                           SRR5189682.105299.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..657
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 27.82 cM"
     Protein         1..657
                     /product="broad substrate specificity ATP-binding cassette
                     transporter ABCG2"
                     /EC_number="7.6.2.2"
                     /note="mitoxantrone resistance protein 1; ATP-binding
                     cassette sub-family G member 2; breast cancer resistance
                     protein 1 homolog; urate exporter; ATP-binding cassette,
                     sub-family G (WHITE), member 2"
                     /calculated_mol_wt=72891
     Region          1..24
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TMS5.1)"
     Region          46..651
                     /region_name="3a01204"
                     /note="The Eye Pigment Precursor Transporter (EPP) Family
                     protein; TIGR00955"
                     /db_xref="CDD:273361"
     Site            394..414
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TMS5.1)"
     Site            429..449
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TMS5.1)"
     Site            478..498
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TMS5.1)"
     Site            507..527
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TMS5.1)"
     Site            536..556
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TMS5.1)"
     Site            596
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TMS5.1)"
     Site            600
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TMS5.1)"
     Site            633..653
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TMS5.1)"
     CDS             1..657
                     /gene="Abcg2"
                     /gene_synonym="ABC15; ABCP; BCRP; Bcrp1; MXR; MXR1"
                     /coded_by="NM_001381927.1:102..2075"
                     /db_xref="GeneID:26357"
                     /db_xref="MGI:MGI:1347061"
ORIGIN      
        1 msssndhvlv pmsqrnnngl prmnsravrt laegdvlsfh hityrvkvks gflvrktvek
       61 eilsdingim kpglnailgp tgggksslld vlaarkdpkg lsgdvlinga pqpahfkccs
      121 gyvvqddvvm gtltvrenlq fsaalrlptt mknhekneri ntiikelgle kvadskvgtq
      181 firgisgger krtsigmeli tdpsilflde pttgldssta navllllkrm skqgrtiifs
      241 ihqprysifk lfdsltllas gklvfhgpaq kaleyfasag yhcepynnpa dffldvingd
      301 ssavmlnree qdneanktee pskgekpvie nlsefyinsa iygetkaeld qlpgaqekkg
      361 tsafkepvyv tsfchqlrwi arrsfknllg npqasvaqli vtvilgliig aiyfdlkyda
      421 agmqnragvl fflttnqcfs svsavelfvv ekklfiheyi sgyyrvssyf fgkvmsdllp
      481 mrflpsvift cilyfmlglk ktvdaffimm ftlimvayta ssmalaiatg qsvvsvatll
      541 mtiafvfmml fsgllvnlrt igpwlswlqy fsiprygfta lqyneflgqe fcpgfnvtdn
      601 stcvnsyaic tgneylinqg ielspwglwk nhvalacmii ifltiaylkl lflkkys
//
LOCUS       NP_035068                503 aa            linear   ROD 09-OCT-2023
DEFINITION  nuclear respiratory factor 1 isoform a [Mus musculus].
ACCESSION   NP_035068
VERSION     NP_035068.3
DBSOURCE    REFSEQ: accession NM_010938.5
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 503)
  AUTHORS   Cheng C, Tian Y, Yang R, Guo W, Xiao K, Zhang F, Tian J, Deng Z,
            Yang W, Yang H and Zhou Z.
  TITLE     miR-5581 Contributes to Osteoarthritis by Targeting NRF1 to Disturb
            the Proliferation and Functions of Chondrocytes
  JOURNAL   Am J Pathol 193 (9), 1234-1247 (2023)
   PUBMED   37611970
  REMARK    GeneRIF: miR-5581 Contributes to Osteoarthritis by Targeting NRF1
            to Disturb the Proliferation and Functions of Chondrocytes.
REFERENCE   2  (residues 1 to 503)
  AUTHORS   Meng Z, Liang B, Wu Y, Liu C, Wang H, Du Y, Gan L, Gao E, Lau WB,
            Christopher TA, Lopez BL, Koch WJ, Ma X, Zhao F, Wang Y and Zhao J.
  TITLE     Hypoadiponectinemia-induced upregulation of microRNA449b
            downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury
            in diabetic mice
  JOURNAL   J Mol Cell Cardiol 182, 1-14 (2023)
   PUBMED   37437402
  REMARK    GeneRIF: Hypoadiponectinemia-induced upregulation of microRNA449b
            downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury
            in diabetic mice.
REFERENCE   3  (residues 1 to 503)
  AUTHORS   Zhao T, Zhang J, Lei H, Meng Y, Cheng H, Zhao Y, Geng G, Mu C, Chen
            L, Liu Q, Luo Q, Zhang C, Long Y, Su J, Wang Y, Li Z, Sun J, Chen
            G, Li Y, Liao X, Shang Y, Hu G, Chen Q and Zhu Y.
  TITLE     NRF1-mediated mitochondrial biogenesis antagonizes innate antiviral
            immunity
  JOURNAL   EMBO J 42 (16), e113258 (2023)
   PUBMED   37409632
  REMARK    GeneRIF: NRF1-mediated mitochondrial biogenesis antagonizes innate
            antiviral immunity.
REFERENCE   4  (residues 1 to 503)
  AUTHORS   Akl MG, Baccetto R, Stebbings BM, Li L and Widenmaier SB.
  TITLE     Euglycemia is affected by stress defense factor hepatocyte NRF1,
            but not NRF2
  JOURNAL   Biochem Biophys Res Commun 668, 96-103 (2023)
   PUBMED   37245295
  REMARK    GeneRIF: Euglycemia is affected by stress defense factor hepatocyte
            NRF1, but not NRF2.
REFERENCE   5  (residues 1 to 503)
  AUTHORS   Akl MG, Li L, Baccetto R, Phanse S, Zhang Q, Trites MJ, McDonald S,
            Aoki H, Babu M and Widenmaier SB.
  TITLE     Complementary gene regulation by NRF1 and NRF2 protects against
            hepatic cholesterol overload
  JOURNAL   Cell Rep 42 (4), 112399 (2023)
   PUBMED   37060561
  REMARK    GeneRIF: Complementary gene regulation by NRF1 and NRF2 protects
            against hepatic cholesterol overload.
            Erratum:[Cell Rep. 2023 Jul 25;42(7):112872. PMID: 37454293]
REFERENCE   6  (residues 1 to 503)
  AUTHORS   Carmona MC, Iglesias R, Obregon MJ, Darlington GJ, Villarroya F and
            Giralt M.
  TITLE     Mitochondrial biogenesis and thyroid status maturation in brown fat
            require CCAAT/enhancer-binding protein alpha
  JOURNAL   J Biol Chem 277 (24), 21489-21498 (2002)
   PUBMED   11940593
REFERENCE   7  (residues 1 to 503)
  AUTHORS   Huo L and Scarpulla RC.
  TITLE     Mitochondrial DNA instability and peri-implantation lethality
            associated with targeted disruption of nuclear respiratory factor 1
            in mice
  JOURNAL   Mol Cell Biol 21 (2), 644-654 (2001)
   PUBMED   11134350
REFERENCE   8  (residues 1 to 503)
  AUTHORS   Schaefer L, Engman H and Miller JB.
  TITLE     Coding sequence, chromosomal localization, and expression pattern
            of Nrf1: the mouse homolog of Drosophila erect wing
  JOURNAL   Mamm Genome 11 (2), 104-110 (2000)
   PUBMED   10656923
REFERENCE   9  (residues 1 to 503)
  AUTHORS   Huo L and Scarpulla RC.
  TITLE     Multiple 5'-untranslated exons in the nuclear respiratory factor 1
            gene span 47 kb and contribute to transcript heterogeneity and
            translational efficiency
  JOURNAL   Gene 233 (1-2), 213-224 (1999)
   PUBMED   10375638
REFERENCE   10 (residues 1 to 503)
  AUTHORS   Virbasius CA, Virbasius JV and Scarpulla RC.
  TITLE     NRF-1, an activator involved in nuclear-mitochondrial interactions,
            utilizes a new DNA-binding domain conserved in a family of
            developmental regulators
  JOURNAL   Genes Dev 7 (12A), 2431-2445 (1993)
   PUBMED   8253388
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134897.4 and AC153632.2.
            
            On Aug 15, 2009 this sequence version replaced NP_035068.2.
            
            Transcript Variant: This variant (6) uses an alternate splice site
            in the 5' UTR, compared to variant 1. Variants 1, 6, 9, and 10 all
            encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.23908.1,
                                           SRR13422597.361757.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 12.47 cM"
     Protein         1..503
                     /product="nuclear respiratory factor 1 isoform a"
                     /note="NRF-1; alpha-pal; alpha palindromic-binding
                     protein"
                     /calculated_mol_wt=53440
     Region          1..78
                     /region_name="Dimerization. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU00.2)"
     Region          36..57
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU00.2)"
     Site            39
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:Q16656; propagated from
                     UniProtKB/Swiss-Prot (Q9WU00.2)"
     Site            44
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:Q16656; propagated from
                     UniProtKB/Swiss-Prot (Q9WU00.2)"
     Site            46
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:Q16656; propagated from
                     UniProtKB/Swiss-Prot (Q9WU00.2)"
     Site            47
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:Q16656; propagated from
                     UniProtKB/Swiss-Prot (Q9WU00.2)"
     Site            52
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:Q16656; propagated from
                     UniProtKB/Swiss-Prot (Q9WU00.2)"
     Region          87..283
                     /region_name="Nrf1_DNA-bind"
                     /note="NLS-binding and DNA-binding and dimerization
                     domains of Nrf1; pfam10491"
                     /db_xref="CDD:402218"
     Region          88..116
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU00.2)"
     Region          301..476
                     /region_name="Required for transcriptional activation.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU00.2)"
     Region          450..502
                     /region_name="Nrf1_activ_bdg"
                     /note="Nrf1 activator activation site binding domain;
                     pfam10492"
                     /db_xref="CDD:431313"
     CDS             1..503
                     /gene="Nrf1"
                     /gene_synonym="D6Ertd415e"
                     /coded_by="NM_010938.5:271..1782"
                     /note="isoform a is encoded by transcript variant 6"
                     /db_xref="CCDS:CCDS19968.1"
                     /db_xref="GeneID:18181"
                     /db_xref="MGI:MGI:1332235"
ORIGIN      
        1 meehgvtqte hmatieahav aqqvqqvhva tytehsmlsa dedspssped tsyddsdiln
       61 staadevtah laaagpvgma aaaavatgkk rkrphvfesn psirkrqqtr llrklratld
      121 eyttrvgqqa ivlcispskp npvfkvfgaa plenvvrkyk smiledlesa laehapapqe
      181 vnselpplti dgipvsvdkm tqaqlrafip emlkystgrg kpgwgkesck piwwpedipw
      241 anvrsdvrte eqkqrvswtq alrtivkncy kqhgredlly afedqqtqtq attthsiahl
      301 vpsqtvvqtf snpdgtvsli qvgtgatvat ladaselptt vtvaqvnysa vadgeveqnw
      361 atlqggemti qttqaseatq avaslaeaav aasqemqqga tvtmalnsea aahavatlae
      421 atlqgggqiv lsgetaaavg altgvqdang lvqipvsmyq tvvtslaqgn gpvqvamapv
      481 ttrisdsavt mdgqavevvt leq
//
LOCUS       NP_001077405             591 aa            linear   ROD 09-OCT-2023
DEFINITION  parathyroid hormone/parathyroid hormone-related peptide receptor
            precursor [Mus musculus].
ACCESSION   NP_001077405
VERSION     NP_001077405.1
DBSOURCE    REFSEQ: accession NM_001083936.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 591)
  AUTHORS   Amano K, Kitaoka Y, Kato S, Fujiwara M, Okuzaki D, Aikawa T, Kogo M
            and Iida S.
  TITLE     Pth1r Signal in Gli1+ Cells Maintains Postnatal Cranial Base
            Synchondrosis
  JOURNAL   J Dent Res 102 (11), 1241-1251 (2023)
   PUBMED   37575041
  REMARK    GeneRIF: Pth1r Signal in Gli1+ Cells Maintains Postnatal Cranial
            Base Synchondrosis.
REFERENCE   2  (residues 1 to 591)
  AUTHORS   Liu H, Wada A, Le I, Le PT, Lee AWF, Zhou J, Gori F, Baron R and
            Rosen CJ.
  TITLE     PTH regulates osteogenesis and suppresses adipogenesis through
            Zfp467 in a feed-forward, PTH1R-cyclic AMP-dependent manner
  JOURNAL   Elife 12, e83345 (2023)
   PUBMED   37159501
  REMARK    GeneRIF: PTH regulates osteogenesis and suppresses adipogenesis
            through Zfp467 in a feed-forward, PTH1R-cyclic AMP-dependent
            manner.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 591)
  AUTHORS   Chu TL, Chen P, Yu AX, Kong M, Tan Z, Tsang KY, Zhou Z and Cheah
            KSE.
  TITLE     MMP14 cleaves PTH1R in the chondrocyte-derived osteoblast lineage,
            curbing signaling intensity for proper bone anabolism
  JOURNAL   Elife 12, e82142 (2023)
   PUBMED   36892459
  REMARK    GeneRIF: MMP14 cleaves PTH1R in the chondrocyte-derived osteoblast
            lineage, curbing signaling intensity for proper bone anabolism.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 591)
  AUTHORS   Wang F, Rummukainen P, Pehkonen M, Saamanen AM, Heino TJ and
            Kiviranta R.
  TITLE     Mesenchymal cell-derived Wnt1 signaling regulates subchondral bone
            remodeling but has no effects on the development of growth plate or
            articular cartilage in mice
  JOURNAL   Bone 163, 116497 (2022)
   PUBMED   35863746
REFERENCE   5  (residues 1 to 591)
  AUTHORS   Kimura T, Panaroni C, Rankin EB, Purton LE and Wu JY.
  TITLE     Loss of Parathyroid Hormone Receptor Signaling in Osteoprogenitors
            Is Associated With Accumulation of Multiple Hematopoietic Lineages
            in the Bone Marrow
  JOURNAL   J Bone Miner Res 37 (7), 1321-1334 (2022)
   PUBMED   35490308
  REMARK    GeneRIF: Loss of Parathyroid Hormone Receptor Signaling in
            Osteoprogenitors Is Associated With Accumulation of Multiple
            Hematopoietic Lineages in the Bone Marrow.
REFERENCE   6  (residues 1 to 591)
  AUTHORS   McCuaig KA, Lee HS, Clarke JC, Assar H, Horsford J and White JH.
  TITLE     Parathyroid hormone/parathyroid hormone related peptide receptor
            gene transcripts are expressed from tissue-specific and ubiquitous
            promoters
  JOURNAL   Nucleic Acids Res 23 (11), 1948-1955 (1995)
   PUBMED   7596823
  REMARK    Erratum:[Nucleic Acids Res 1995 Aug 11;23(15):3082]
REFERENCE   7  (residues 1 to 591)
  AUTHORS   Karperien M, van Dijk TB, Hoeijmakers T, Cremers F, Abou-Samra AB,
            Boonstra J, de Laat SW and Defize LH.
  TITLE     Expression pattern of parathyroid hormone/parathyroid hormone
            related peptide receptor mRNA in mouse postimplantation embryos
            indicates involvement in multiple developmental processes
  JOURNAL   Mech Dev 47 (1), 29-42 (1994)
   PUBMED   7524627
REFERENCE   8  (residues 1 to 591)
  AUTHORS   Kong XF, Schipani E, Lanske B, Joun H, Karperien M, Defize LH,
            Juppner H, Potts JT Jr, Segre GV, Kronenberg HM et al.
  TITLE     The rat, mouse and human genes encoding the receptor for
            parathyroid hormone and parathyroid hormone-related peptide are
            highly homologous
  JOURNAL   Biochem Biophys Res Commun 200 (3), 1290-1299 (1994)
   PUBMED   8185578
  REMARK    Erratum:[Biochem Biophys Res Commun. 1994 Jun 15;201(2):1058. PMID:
            8002976]
REFERENCE   9  (residues 1 to 591)
  AUTHORS   Pausova Z, Bourdon J, Clayton D, Mattei MG, Seldin MF, Janicic N,
            Riviere M, Szpirer J, Levan G, Szpirer C et al.
  TITLE     Cloning of a parathyroid hormone/parathyroid hormone-related
            peptide receptor (PTHR) cDNA from a rat osteosarcoma (UMR 106) cell
            line: chromosomal assignment of the gene in the human, mouse, and
            rat genomes
  JOURNAL   Genomics 20 (1), 20-26 (1994)
   PUBMED   8020952
REFERENCE   10 (residues 1 to 591)
  AUTHORS   Seldin MF, Mattei MG and Hendy GN.
  TITLE     Localization of mouse parathyroid hormone-like peptide gene (Pthlh)
            to distal chromosome 6 using interspecific backcross mice and in
            situ hybridization
  JOURNAL   Cytogenet Cell Genet 60 (3-4), 252-254 (1992)
   PUBMED   1354597
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB614354.1, BC051981.1 and AI607947.1.
            
            Transcript Variant: This variant (3) represents the longest
            transcript. Variants 1, 2, and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC051981.1, SRR7345562.3290190.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN01164140
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..591
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 60.56 cM"
     Protein         1..591
                     /product="parathyroid hormone/parathyroid hormone-related
                     peptide receptor precursor"
                     /note="parathyroid hormone receptor 1; parathyroid
                     hormone/parathyroid hormone-related peptide receptor; PTH1
                     receptor; PTH/PTHr receptor; PTH/PTHrP type I receptor;
                     PTH-related peptide receptor; PTH/PTHrP receptor"
                     /calculated_mol_wt=63570
     sig_peptide     1..28
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=2820
     Region          67..104
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P41593.2)"
     Region          105..170
                     /region_name="HRM"
                     /note="Hormone receptor domain; pfam02793"
                     /db_xref="CDD:397086"
     Site            151
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P41593.2)"
     Site            161
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P41593.2)"
     Site            166
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P41593.2)"
     Site            176
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P41593.2)"
     Region          184..476
                     /region_name="7tm_GPCRs"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; cl28897"
                     /db_xref="CDD:452889"
     Region          187..211
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:410628"
     Site            189..212
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P41593.2)"
     Region          220..241
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:410628"
     Site            220..239
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P41593.2)"
     Region          282..304
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:410628"
     Site            283..306
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P41593.2)"
     Site            321..342
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P41593.2)"
     Region          323..339
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:410628"
     Region          356..379
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:410628"
     Site            362..382
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P41593.2)"
     Region          407..429
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:410628"
     Site            410..428
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P41593.2)"
     Region          438..463
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:410628"
     Site            441..463
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P41593.2)"
     Region          474..477
                     /region_name="Important for interaction with G proteins.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P41593.2)"
     CDS             1..591
                     /gene="Pth1r"
                     /gene_synonym="PPR; Pthr; Pthr1"
                     /coded_by="NM_001083936.1:311..2086"
                     /db_xref="CCDS:CCDS52940.1"
                     /db_xref="GeneID:19228"
                     /db_xref="MGI:MGI:97801"
ORIGIN      
        1 mgtariapsl alllccpvls sayalvdadd vftkeeqifl lhraqaqcdk llkevlhtaa
       61 nimesdkgwt pastsgkprk ekapgkfype skenkdvptg srrrgrpclp ewdnivcwpl
      121 gapgevvavp cpdyiydfnh kghayrrcdr ngswevvpgh nrtwanysec lkfmtnetre
      181 revfdrlgmi ytvgysmsla sltvavlila yfrrlhctrn yihmhmflsf mlraasifvk
      241 davlysgftl deaerlteee lhiiaqvppp paaaavgyag crvavtffly flatnyywil
      301 veglylhsli fmaffsekky lwgftifgwg lpavfvavwv gvratlantg cwdlssghkk
      361 wiiqvpilas vvlnfilfin iirvlatklr etnagrcdtr qqyrkllrst lvlvplfgvh
      421 ytvfmalpyt evsgtlwqiq mhyemlfnsf qgffvaiiyc fcngevqaei rkswsrwtla
      481 ldfkrkarsg sssysygpmv shtsvtnvgp raglslplsp rllpattngh sqlpghakpg
      541 apaienetip vtmtvpkddg flngscsgld eeasgsarpp pllqeewetv m
//
LOCUS       NP_001349232             500 aa            linear   ROD 09-OCT-2023
DEFINITION  CUGBP Elav-like family member 4 isoform 27 [Mus musculus].
ACCESSION   NP_001349232
VERSION     NP_001349232.1
DBSOURCE    REFSEQ: accession NM_001362303.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 500)
  AUTHORS   Salamon I, Park Y, Miskic T, Kopic J, Matteson P, Page NF, Roque A,
            McAuliffe GW, Favate J, Garcia-Forn M, Shah P, Judas M, Millonig
            JH, Kostovic I, De Rubeis S, Hart RP, Krsnik Z and Rasin MR.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    GeneRIF: Celf4 controls mRNA translation underlying synaptic
            development in the prenatal mammalian neocortex.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 500)
  AUTHORS   Shen Y, Zhang C, Xiao K, Liu D and Xie G.
  TITLE     CELF4 regulates spine formation and depression-like behaviors of
            mice
  JOURNAL   Biochem Biophys Res Commun 605, 39-44 (2022)
   PUBMED   35306363
  REMARK    GeneRIF: CELF4 regulates spine formation and depression-like
            behaviors of mice.
REFERENCE   3  (residues 1 to 500)
  AUTHORS   Moreau MX, Saillour Y, Cwetsch AW, Pierani A and Causeret F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   4  (residues 1 to 500)
  AUTHORS   Li C, Li X, Bi Z, Sugino K, Wang G, Zhu T and Liu Z.
  TITLE     Comprehensive transcriptome analysis of cochlear spiral ganglion
            neurons at multiple ages
  JOURNAL   Elife 9, e50491 (2020)
   PUBMED   31913118
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 500)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 500)
  AUTHORS   Ladd AN, Taffet G, Hartley C, Kearney DL and Cooper TA.
  TITLE     Cardiac tissue-specific repression of CELF activity disrupts
            alternative splicing and causes cardiomyopathy
  JOURNAL   Mol Cell Biol 25 (14), 6267-6278 (2005)
   PUBMED   15988035
  REMARK    GeneRIF: CELF protein activity is required for normal alternative
            splicing in the heart in vivo and normal CELF-mediated alternative
            splicing regulation is in turn required for normal cardiac
            function.
REFERENCE   7  (residues 1 to 500)
  AUTHORS   Meins M, Schlickum S, Wilhelm C, Missbach J, Yadav S, Glaser B,
            Grzmil M, Burfeind P and Laccone F.
  TITLE     Identification and characterization of murine Brunol4, a new member
            of the elav/bruno family
  JOURNAL   Cytogenet Genome Res 97 (3-4), 254-260 (2002)
   PUBMED   12438720
  REMARK    GeneRIF: cloning and characterization
REFERENCE   8  (residues 1 to 500)
  AUTHORS   Ladd AN, Charlet N and Cooper TA.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   9  (residues 1 to 500)
  AUTHORS   Good PJ, Chen Q, Warner SJ and Herring DC.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
REFERENCE   10 (residues 1 to 500)
  AUTHORS   Yulug IG, Egan SE, See CG and Fisher EM.
  TITLE     Mapping GRB2, a signal transduction gene in the human and the mouse
  JOURNAL   Genomics 22 (2), 313-318 (1994)
   PUBMED   7806216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121094.8 and AC144938.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660819.123141.1,
                                           SRR6116558.98916.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 13.92 cM"
     Protein         1..500
                     /product="CUGBP Elav-like family member 4 isoform 27"
                     /note="CUG-BP- and ETR-3-like factor 4; bruno-like protein
                     4; RNA-binding protein BRUNOL-4; bruno-like 4, RNA binding
                     protein"
                     /calculated_mol_wt=53371
     Region          49..135
                     /region_name="RRM1_CELF3_4_5_6"
                     /note="RNA recognition motif 1 (RRM1) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12632"
                     /db_xref="CDD:410041"
     Site            order(55,57,59..60,63,82,84,86,95..97,99,129,131)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410041"
     Region          150..230
                     /region_name="RRM2_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12635"
                     /db_xref="CDD:410043"
     Site            order(152,154,156..157,160,179,181,183,191..193,195,225,
                     227)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410043"
     Region          415..489
                     /region_name="RRM_SF"
                     /note="RNA recognition motif (RRM) superfamily; cl17169"
                     /db_xref="CDD:450164"
     CDS             1..500
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /coded_by="NM_001362303.1:531..2033"
                     /note="isoform 27 is encoded by transcript variant 32"
                     /db_xref="GeneID:108013"
                     /db_xref="MGI:MGI:1932407"
ORIGIN      
        1 myikmatlan gqadnaslst nglgsspgsa ghmnglshsp gnpstipmkd hdaiklfigq
       61 iprnldekdl kplfeefgki yeltvlkdrf tgmhkgcafl tyceresalk aqsalheqkt
      121 lpgmnrpiqv kpadsesrgg ssclrqppsh rklfvgmlnk qqseddvrrl feafgnieec
      181 tilrgpdgns kgcafvkyss haeaqaaina lhgsqtmpga ssslvvkfad tdkertmrrm
      241 qqmagqmgmf npmaipfgay gayaqalmqq qaalmasvaq ggylnpmaaf aaaqmqqmaa
      301 lnmnglaaap mtptsggstp pgitapavps ipspigvngf tglppqangq paaeavfang
      361 ihpypaqspt aadplqqaya gvqqyagpay paaygqisqa fpqpppmipq qqregpegcn
      421 lliyhlpqef gdaelmqmfl pfgnvisskv fvdratnqsf vsfdnpasaq taiqamngfq
      481 igmkrlkvql krpkdanrpy
//
LOCUS       NP_032363                155 aa            linear   ROD 09-OCT-2023
DEFINITION  interferon gamma precursor [Mus musculus].
ACCESSION   NP_032363
VERSION     NP_032363.1
DBSOURCE    REFSEQ: accession NM_008337.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 155)
  AUTHORS   Xiao H, Zhao Q, Yuan J, Liang W, Wu R, Wen Y, Du S, Wang Y, Zhao S,
            Lang Y, Yan Q, Huang X and Cao S.
  TITLE     IFN-gamma promotes PANoptosis in Pasteurella multocida
            toxin-induced pneumonia in mice
  JOURNAL   Vet Microbiol 285, 109848 (2023)
   PUBMED   37722207
  REMARK    GeneRIF: IFN-gamma promotes PANoptosis in Pasteurella multocida
            toxin-induced pneumonia in mice.
REFERENCE   2  (residues 1 to 155)
  AUTHORS   Clark DN, O'Neil SM, Xu L, Steppe JT, Savage JT, Raghunathan K and
            Filiano AJ.
  TITLE     Prolonged STAT1 activation in neurons drives a pathological
            transcriptional response
  JOURNAL   J Neuroimmunol 382, 578168 (2023)
   PUBMED   37556887
  REMARK    GeneRIF: Prolonged STAT1 activation in neurons drives a
            pathological transcriptional response.
REFERENCE   3  (residues 1 to 155)
  AUTHORS   Centofanti E, Wang C, Iyer S, Krichevsky O, Oyler-Yaniv A and
            Oyler-Yaniv J.
  TITLE     The spread of interferon-gamma in melanomas is highly spatially
            confined, driving nongenetic variability in tumor cells
  JOURNAL   Proc Natl Acad Sci U S A 120 (35), e2304190120 (2023)
   PUBMED   37603742
  REMARK    GeneRIF: The spread of interferon-gamma in melanomas is highly
            spatially confined, driving nongenetic variability in tumor cells.
REFERENCE   4  (residues 1 to 155)
  AUTHORS   Emami S, Rojas Converso T, Persson JJ and Johansson-Lindbom B.
  TITLE     Insertion of an immunodominant T helper cell epitope within the
            Group A Streptococcus M protein promotes an IFN-gamma-dependent
            shift from a non-protective to a protective immune response
  JOURNAL   Front Immunol 14, 1241485 (2023)
   PUBMED   37654501
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 155)
  AUTHORS   Dalton DK, Pitts-Meek S, Keshav S, Figari IS, Bradley A and Stewart
            TA.
  TITLE     Multiple defects of immune cell function in mice with disrupted
            interferon-gamma genes
  JOURNAL   Science 259 (5102), 1739-1742 (1993)
   PUBMED   8456300
REFERENCE   6  (residues 1 to 155)
  AUTHORS   Beier DR, Dushkin H and Sussman DJ.
  TITLE     Mapping genes in the mouse using single-strand conformation
            polymorphism analysis of recombinant inbred strains and
            interspecific crosses
  JOURNAL   Proc Natl Acad Sci U S A 89 (19), 9102-9106 (1992)
   PUBMED   1409609
REFERENCE   7  (residues 1 to 155)
  AUTHORS   Shimizu A, Sakai Y, Ohno K, Masaki S, Kuwano R, Takahashi Y,
            Miyashita N and Watanabe T.
  TITLE     A molecular genetic linkage map of mouse chromosome 10, including
            the Myb, S100b, Pah, Sl, and Ifg genes
  JOURNAL   Biochem Genet 30 (9-10), 529-535 (1992)
   PUBMED   1359872
REFERENCE   8  (residues 1 to 155)
  AUTHORS   Crnic LS and Segall MA.
  TITLE     Behavioral effects of mouse interferons-alpha and -gamma and human
            interferon-alpha in mice
  JOURNAL   Brain Res 590 (1-2), 277-284 (1992)
   PUBMED   1422836
REFERENCE   9  (residues 1 to 155)
  AUTHORS   Salkowski CA and Vogel SN.
  TITLE     IFN-gamma mediates increased glucocorticoid receptor expression in
            murine macrophages
  JOURNAL   J Immunol 148 (9), 2770-2777 (1992)
   PUBMED   1315358
REFERENCE   10 (residues 1 to 155)
  AUTHORS   Hamilton TA, Bredon N, Ohmori Y and Tannenbaum CS.
  TITLE     IFN-gamma and IFN-beta independently stimulate the expression of
            lipopolysaccharide-inducible genes in murine peritoneal macrophages
  JOURNAL   J Immunol 142 (7), 2325-2331 (1989)
   PUBMED   2494257
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC153498.17.
            
            Summary: This gene encodes a soluble cytokine that is a member of
            the type II interferon class. The encoded protein is secreted by
            cells of both the innate and adaptive immune systems. The active
            protein is a homodimer that binds to the interferon gamma receptor
            which triggers a cellular response to viral and microbial
            infections. Mice deficient in this gene have increased
            susceptibility to viral, bacterial and parasitic infections and to
            several autoimmune diseases. [provided by RefSeq, Dec 2015].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M28621.1, K00083.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849388
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..155
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 66.75 cM"
     Protein         1..155
                     /product="interferon gamma precursor"
                     /note="IFN-gamma; gamma interferon; interferon 2f"
                     /calculated_mol_wt=15522
     sig_peptide     1..22
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=2403
     Region          14..150
                     /region_name="IFN-gamma"
                     /note="Interferon gamma; pfam00714"
                     /db_xref="CDD:395581"
     mat_peptide     23..155
                     /product="Interferon gamma. /id=PRO_0000016453"
                     /note="propagated from UniProtKB/Swiss-Prot (P01580.1)"
                     /calculated_mol_wt=15522
     Site            38
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (P01580.1)"
     Site            90
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (P01580.1)"
     CDS             1..155
                     /gene="Ifng"
                     /gene_synonym="If2f; Ifg; IFN-g"
                     /coded_by="NM_008337.4:110..577"
                     /db_xref="CCDS:CCDS24200.1"
                     /db_xref="GeneID:15978"
                     /db_xref="MGI:MGI:107656"
ORIGIN      
        1 mnathcilal qlflmavsgc ychgtviesl eslnnyfnss gidveekslf ldiwrnwqkd
       61 gdmkilqsqi isfylrlfev lkdnqaisnn isvieshlit tffsnskakk dafmsiakfe
      121 vnnpqvqrqa fnelirvvhq llpesslrkr krsrc
//
LOCUS       NP_033884                110 aa            linear   ROD 09-OCT-2023
DEFINITION  bcl-2-like protein 11 isoform 3 [Mus musculus].
ACCESSION   NP_033884
VERSION     NP_033884.1
DBSOURCE    REFSEQ: accession NM_009754.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 110)
  AUTHORS   Jiang M, Wang XB and Jiang S.
  TITLE     circ_0000018 downregulation peripherally ameliorates
            neuroprotection against acute ischemic stroke through the
            miR-871/BCL2L11 axis
  JOURNAL   Mol Med Rep 28 (5) (2023)
   PUBMED   37772397
  REMARK    GeneRIF: circ_0000018 downregulation peripherally ameliorates
            neuroprotection against acute ischemic stroke through the
            miR-871/BCL2L11 axis.
REFERENCE   2  (residues 1 to 110)
  AUTHORS   Lu Y, Tang K, Wang S, Tian Z, Fan Y, Li B, Wang M, Zhao J and Xie
            J.
  TITLE     Dach1 deficiency drives alveolar epithelium apoptosis in pulmonary
            fibrosis via modulating C-Jun/Bim activity
  JOURNAL   Transl Res 257, 54-65 (2023)
   PUBMED   36754276
  REMARK    GeneRIF: Dach1 deficiency drives alveolar epithelium apoptosis in
            pulmonary fibrosis via modulating C-Jun/Bim activity.
REFERENCE   3  (residues 1 to 110)
  AUTHORS   Nguyen HV, Vandenberg CJ, Robati MR, Ng AP and Cory S.
  TITLE     MNT suppresses T cell apoptosis via BIM and is critical for T
            lymphomagenesis
  JOURNAL   Cell Death Differ 30 (4), 1018-1032 (2023)
   PUBMED   36755068
  REMARK    GeneRIF: MNT suppresses T cell apoptosis via BIM and is critical
            for T lymphomagenesis.
REFERENCE   4  (residues 1 to 110)
  AUTHORS   Chen H, Bai Y, Kobayashi M, Xiao S, Cai W, Barajas S, Chen S, Miao
            J, Meke FN, Vemula S, Ropa JP, Croop JM, Boswell HS, Wan J, Jia Y,
            Liu H, Li LS, Altman JK, Eklund EA, Ji P, Tong W, Band H, Huang DT,
            Platanias LC, Zhang ZY and Liu Y.
  TITLE     PRL2 phosphatase enhances oncogenic FLT3 signaling via
            dephosphorylation of the E3 ubiquitin ligase CBL at tyrosine 371
  JOURNAL   Blood 141 (3), 244-259 (2023)
   PUBMED   36206490
REFERENCE   5  (residues 1 to 110)
  AUTHORS   Brahma MK, Xiao P, Popa M, Negueruela J, Vandenbempt V, Demine S,
            Cardozo AK and Gurzov EN.
  TITLE     Nova1 or Bim Deficiency in Pancreatic beta-Cells Does Not Alter
            Multiple Low-Dose Streptozotocin-Induced Diabetes and Diet-Induced
            Obesity in Mice
  JOURNAL   Nutrients 14 (18), 3866 (2022)
   PUBMED   36145242
  REMARK    GeneRIF: Nova1 or Bim Deficiency in Pancreatic beta-Cells Does Not
            Alter Multiple Low-Dose Streptozotocin-Induced Diabetes and
            Diet-Induced Obesity in Mice.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 110)
  AUTHORS   Bouillet P, Zhang LC, Huang DC, Webb GC, Bottema CD, Shore P, Eyre
            HJ, Sutherland GR and Adams JM.
  TITLE     Gene structure alternative splicing, and chromosomal localization
            of pro-apoptotic Bcl-2 relative Bim
  JOURNAL   Mamm Genome 12 (2), 163-168 (2001)
   PUBMED   11210187
REFERENCE   7  (residues 1 to 110)
  AUTHORS   Bouillet P, Metcalf D, Huang DC, Tarlinton DM, Kay TW, Kontgen F,
            Adams JM and Strasser A.
  TITLE     Proapoptotic Bcl-2 relative Bim required for certain apoptotic
            responses, leukocyte homeostasis, and to preclude autoimmunity
  JOURNAL   Science 286 (5445), 1735-1738 (1999)
   PUBMED   10576740
REFERENCE   8  (residues 1 to 110)
  AUTHORS   Puthalakath H, Huang DC, O'Reilly LA, King SM and Strasser A.
  TITLE     The proapoptotic activity of the Bcl-2 family member Bim is
            regulated by interaction with the dynein motor complex
  JOURNAL   Mol Cell 3 (3), 287-296 (1999)
   PUBMED   10198631
REFERENCE   9  (residues 1 to 110)
  AUTHORS   Reed JC.
  TITLE     Bcl-2 family proteins
  JOURNAL   Oncogene 17 (25), 3225-3236 (1998)
   PUBMED   9916985
  REMARK    Review article
REFERENCE   10 (residues 1 to 110)
  AUTHORS   O'Connor L, Strasser A, O'Reilly LA, Hausmann G, Adams JM, Cory S
            and Huang DC.
  TITLE     Bim: a novel member of the Bcl-2 family that promotes apoptosis
  JOURNAL   EMBO J 17 (2), 384-395 (1998)
   PUBMED   9430630
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK037885.1, AF032461.1, AK082613.1, CB521709.1, CA321725.1,
            AA881651.1 and BE136124.1.
            
            Transcript Variant: This variant (3) uses an alternate in-frame
            splice site in the central coding region, compared to variant 1,
            resulting in an isoform (3) that is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK150464.1, AK153542.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..110
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 62.23 cM"
     Protein         1..110
                     /product="bcl-2-like protein 11 isoform 3"
                     /note="bcl-2-like protein 11; bcl2-interacting mediator of
                     cell death; Bcl2 interacting mediator of cell death;
                     BCL2-like 11 (apoptosis facilitator)"
                     /calculated_mol_wt=12823
     Region          4..40
                     /region_name="Bim_N"
                     /note="Bim protein N-terminus; pfam06773"
                     /db_xref="CDD:429111"
     Region          43..78
                     /region_name="Bclx_interact"
                     /note="Bcl-x interacting, BH3 domain; pfam08945"
                     /db_xref="CDD:430337"
     CDS             1..110
                     /gene="Bcl2l11"
                     /gene_synonym="1500006F24Rik; bcl2-L-11; Bim; Bod"
                     /coded_by="NM_009754.3:229..561"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS16712.1"
                     /db_xref="GeneID:12125"
                     /db_xref="MGI:MGI:1197519"
ORIGIN      
        1 makqpsdvss ecdreggqlq paerppqlrp gaptslqtep qasirqsqee pedlrpeiri
       61 aqelrrigde fnetytrrvf andyreaedh pqmvilqllr fifrlvwrrh
//
LOCUS       NP_001349259             473 aa            linear   ROD 09-OCT-2023
DEFINITION  CUGBP Elav-like family member 4 isoform 48 [Mus musculus].
ACCESSION   NP_001349259
VERSION     NP_001349259.1
DBSOURCE    REFSEQ: accession NM_001362330.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 473)
  AUTHORS   Salamon I, Park Y, Miskic T, Kopic J, Matteson P, Page NF, Roque A,
            McAuliffe GW, Favate J, Garcia-Forn M, Shah P, Judas M, Millonig
            JH, Kostovic I, De Rubeis S, Hart RP, Krsnik Z and Rasin MR.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    GeneRIF: Celf4 controls mRNA translation underlying synaptic
            development in the prenatal mammalian neocortex.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 473)
  AUTHORS   Shen Y, Zhang C, Xiao K, Liu D and Xie G.
  TITLE     CELF4 regulates spine formation and depression-like behaviors of
            mice
  JOURNAL   Biochem Biophys Res Commun 605, 39-44 (2022)
   PUBMED   35306363
  REMARK    GeneRIF: CELF4 regulates spine formation and depression-like
            behaviors of mice.
REFERENCE   3  (residues 1 to 473)
  AUTHORS   Moreau MX, Saillour Y, Cwetsch AW, Pierani A and Causeret F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   4  (residues 1 to 473)
  AUTHORS   Li C, Li X, Bi Z, Sugino K, Wang G, Zhu T and Liu Z.
  TITLE     Comprehensive transcriptome analysis of cochlear spiral ganglion
            neurons at multiple ages
  JOURNAL   Elife 9, e50491 (2020)
   PUBMED   31913118
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 473)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 473)
  AUTHORS   Ladd AN, Taffet G, Hartley C, Kearney DL and Cooper TA.
  TITLE     Cardiac tissue-specific repression of CELF activity disrupts
            alternative splicing and causes cardiomyopathy
  JOURNAL   Mol Cell Biol 25 (14), 6267-6278 (2005)
   PUBMED   15988035
  REMARK    GeneRIF: CELF protein activity is required for normal alternative
            splicing in the heart in vivo and normal CELF-mediated alternative
            splicing regulation is in turn required for normal cardiac
            function.
REFERENCE   7  (residues 1 to 473)
  AUTHORS   Meins M, Schlickum S, Wilhelm C, Missbach J, Yadav S, Glaser B,
            Grzmil M, Burfeind P and Laccone F.
  TITLE     Identification and characterization of murine Brunol4, a new member
            of the elav/bruno family
  JOURNAL   Cytogenet Genome Res 97 (3-4), 254-260 (2002)
   PUBMED   12438720
  REMARK    GeneRIF: cloning and characterization
REFERENCE   8  (residues 1 to 473)
  AUTHORS   Ladd AN, Charlet N and Cooper TA.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   9  (residues 1 to 473)
  AUTHORS   Good PJ, Chen Q, Warner SJ and Herring DC.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
REFERENCE   10 (residues 1 to 473)
  AUTHORS   Yulug IG, Egan SE, See CG and Fisher EM.
  TITLE     Mapping GRB2, a signal transduction gene in the human and the mouse
  JOURNAL   Genomics 22 (2), 313-318 (1994)
   PUBMED   7806216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121094.8 and AC144938.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.155916.1,
                                           SRR1660813.153469.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..473
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 13.92 cM"
     Protein         1..473
                     /product="CUGBP Elav-like family member 4 isoform 48"
                     /note="CUG-BP- and ETR-3-like factor 4; bruno-like protein
                     4; RNA-binding protein BRUNOL-4; bruno-like 4, RNA binding
                     protein"
                     /calculated_mol_wt=50476
     Region          49..135
                     /region_name="RRM1_CELF3_4_5_6"
                     /note="RNA recognition motif 1 (RRM1) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12632"
                     /db_xref="CDD:410041"
     Site            order(55,57,59..60,63,82,84,86,95..97,99,129,131)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410041"
     Region          140..220
                     /region_name="RRM2_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12635"
                     /db_xref="CDD:410043"
     Site            order(142,144,146..147,150,169,171,173,181..183,185,215,
                     217)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410043"
     Region          404..462
                     /region_name="RRM_SF"
                     /note="RNA recognition motif (RRM) superfamily; cl17169"
                     /db_xref="CDD:450164"
     CDS             1..473
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /coded_by="NM_001362330.1:531..1952"
                     /note="isoform 48 is encoded by transcript variant 50"
                     /db_xref="GeneID:108013"
                     /db_xref="MGI:MGI:1932407"
ORIGIN      
        1 myikmatlan gqadnaslst nglgsspgsa ghmnglshsp gnpstipmkd hdaiklfigq
       61 iprnldekdl kplfeefgki yeltvlkdrf tgmhkgcafl tyceresalk aqsalheqkt
      121 lpgmnrpiqv kpadsesrgd rklfvgmlnk qqseddvrrl feafgnieec tilrgpdgns
      181 kgcafvkyss haeaqaaina lhgsqtmpga ssslvvkfad tdkertmrrm qqmagqmgmf
      241 npmaipfgay gayaqamqqq aalmasvaqg gylnpmaafa aaqmqqmaal nmnglaaapm
      301 tptsggstpp gitapavpsi pspigvngft glppqangqp aaeavfangi hpypaqspta
      361 adplqqayag vqqyagpayp aaygqisqaf pqpppmipqq qregpegcnl liyhlpqefg
      421 daelmqmflp fgfvsfdnpa saqtaiqamn gfqigmkrlk vqlkrpkdan rpy
//
LOCUS       NP_001349204             554 aa            linear   ROD 09-OCT-2023
DEFINITION  CUGBP Elav-like family member 4 isoform 1 [Mus musculus].
ACCESSION   NP_001349204
VERSION     NP_001349204.1
DBSOURCE    REFSEQ: accession NM_001362275.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 554)
  AUTHORS   Salamon I, Park Y, Miskic T, Kopic J, Matteson P, Page NF, Roque A,
            McAuliffe GW, Favate J, Garcia-Forn M, Shah P, Judas M, Millonig
            JH, Kostovic I, De Rubeis S, Hart RP, Krsnik Z and Rasin MR.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    GeneRIF: Celf4 controls mRNA translation underlying synaptic
            development in the prenatal mammalian neocortex.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 554)
  AUTHORS   Shen Y, Zhang C, Xiao K, Liu D and Xie G.
  TITLE     CELF4 regulates spine formation and depression-like behaviors of
            mice
  JOURNAL   Biochem Biophys Res Commun 605, 39-44 (2022)
   PUBMED   35306363
  REMARK    GeneRIF: CELF4 regulates spine formation and depression-like
            behaviors of mice.
REFERENCE   3  (residues 1 to 554)
  AUTHORS   Moreau MX, Saillour Y, Cwetsch AW, Pierani A and Causeret F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   4  (residues 1 to 554)
  AUTHORS   Li C, Li X, Bi Z, Sugino K, Wang G, Zhu T and Liu Z.
  TITLE     Comprehensive transcriptome analysis of cochlear spiral ganglion
            neurons at multiple ages
  JOURNAL   Elife 9, e50491 (2020)
   PUBMED   31913118
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 554)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 554)
  AUTHORS   Ladd AN, Taffet G, Hartley C, Kearney DL and Cooper TA.
  TITLE     Cardiac tissue-specific repression of CELF activity disrupts
            alternative splicing and causes cardiomyopathy
  JOURNAL   Mol Cell Biol 25 (14), 6267-6278 (2005)
   PUBMED   15988035
  REMARK    GeneRIF: CELF protein activity is required for normal alternative
            splicing in the heart in vivo and normal CELF-mediated alternative
            splicing regulation is in turn required for normal cardiac
            function.
REFERENCE   7  (residues 1 to 554)
  AUTHORS   Meins M, Schlickum S, Wilhelm C, Missbach J, Yadav S, Glaser B,
            Grzmil M, Burfeind P and Laccone F.
  TITLE     Identification and characterization of murine Brunol4, a new member
            of the elav/bruno family
  JOURNAL   Cytogenet Genome Res 97 (3-4), 254-260 (2002)
   PUBMED   12438720
  REMARK    GeneRIF: cloning and characterization
REFERENCE   8  (residues 1 to 554)
  AUTHORS   Ladd AN, Charlet N and Cooper TA.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   9  (residues 1 to 554)
  AUTHORS   Good PJ, Chen Q, Warner SJ and Herring DC.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
REFERENCE   10 (residues 1 to 554)
  AUTHORS   Yulug IG, Egan SE, See CG and Fisher EM.
  TITLE     Mapping GRB2, a signal transduction gene in the human and the mouse
  JOURNAL   Genomics 22 (2), 313-318 (1994)
   PUBMED   7806216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121094.8 and AC144938.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.141098.1,
                                           SRR17784643.231175.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..554
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 13.92 cM"
     Protein         1..554
                     /product="CUGBP Elav-like family member 4 isoform 1"
                     /note="CUG-BP- and ETR-3-like factor 4; bruno-like protein
                     4; RNA-binding protein BRUNOL-4; bruno-like 4, RNA binding
                     protein"
                     /calculated_mol_wt=59011
     Region          18..39
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          49..135
                     /region_name="RRM1_CELF3_4_5_6"
                     /note="RNA recognition motif 1 (RRM1) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12632"
                     /db_xref="CDD:410041"
     Site            order(55,57,59..60,63,82,84,86,95..97,99,129,131)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410041"
     Region          121..149
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          150..230
                     /region_name="RRM2_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12635"
                     /db_xref="CDD:410043"
     Site            order(152,154,156..157,160,179,181,183,191..193,195,225,
                     227)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410043"
     Region          238..257
                     /region_name="Necessary for TNNT2 exon 5 inclusion.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          415..>463
                     /region_name="RRM_SF"
                     /note="RNA recognition motif (RRM) superfamily; cl17169"
                     /db_xref="CDD:450164"
     CDS             1..554
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /coded_by="NM_001362275.1:531..2195"
                     /note="isoform 1 is encoded by transcript variant 7"
                     /db_xref="GeneID:108013"
                     /db_xref="MGI:MGI:1932407"
ORIGIN      
        1 myikmatlan gqadnaslst nglgsspgsa ghmnglshsp gnpstipmkd hdaiklfigq
       61 iprnldekdl kplfeefgki yeltvlkdrf tgmhkgcafl tyceresalk aqsalheqkt
      121 lpgmnrpiqv kpadsesrgg ssclrqppsh rklfvgmlnk qqseddvrrl feafgnieec
      181 tilrgpdgns kgcafvkyss haeaqaaina lhgsqtmpga ssslvvkfad tdkertmrrm
      241 qqmagqmgmf npmaipfgay gayaqalmqq qaalmasvaq ggylnpmaaf aaaqmqqmaa
      301 lnmnglaaap mtptsggstp pgitapavps ipspigvngf tglppqangq paaeavfang
      361 ihpypaqspt aadplqqaya gvqqyagpay paaygqisqa fpqpppmipq qqregpegcn
      421 lliyhlpqef gdaelmqmfl pfgnvisskv fvdratnqsk cfgrhpvpsr cqapscqggq
      481 caisssarrl relrqpgqrt drhpgherlp drheeaqgaa eaaqrrqspv lsaggsvprg
      541 rpglaqgrml nglh
//
LOCUS       NP_573458                484 aa            linear   ROD 09-OCT-2023
DEFINITION  CUGBP Elav-like family member 4 isoform 38 [Mus musculus].
ACCESSION   NP_573458 NP_001349248 XP_911731 XP_924980 XP_924996 XP_925007
            XP_925015 XP_925023 XP_925036 XP_925049 XP_925072 XP_925081
            XP_925093 XP_925104 XP_925118 XP_925132
VERSION     NP_573458.2
DBSOURCE    REFSEQ: accession NM_133195.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 484)
  AUTHORS   Salamon I, Park Y, Miskic T, Kopic J, Matteson P, Page NF, Roque A,
            McAuliffe GW, Favate J, Garcia-Forn M, Shah P, Judas M, Millonig
            JH, Kostovic I, De Rubeis S, Hart RP, Krsnik Z and Rasin MR.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    GeneRIF: Celf4 controls mRNA translation underlying synaptic
            development in the prenatal mammalian neocortex.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 484)
  AUTHORS   Shen Y, Zhang C, Xiao K, Liu D and Xie G.
  TITLE     CELF4 regulates spine formation and depression-like behaviors of
            mice
  JOURNAL   Biochem Biophys Res Commun 605, 39-44 (2022)
   PUBMED   35306363
  REMARK    GeneRIF: CELF4 regulates spine formation and depression-like
            behaviors of mice.
REFERENCE   3  (residues 1 to 484)
  AUTHORS   Moreau MX, Saillour Y, Cwetsch AW, Pierani A and Causeret F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   4  (residues 1 to 484)
  AUTHORS   Li C, Li X, Bi Z, Sugino K, Wang G, Zhu T and Liu Z.
  TITLE     Comprehensive transcriptome analysis of cochlear spiral ganglion
            neurons at multiple ages
  JOURNAL   Elife 9, e50491 (2020)
   PUBMED   31913118
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 484)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 484)
  AUTHORS   Ladd AN, Taffet G, Hartley C, Kearney DL and Cooper TA.
  TITLE     Cardiac tissue-specific repression of CELF activity disrupts
            alternative splicing and causes cardiomyopathy
  JOURNAL   Mol Cell Biol 25 (14), 6267-6278 (2005)
   PUBMED   15988035
  REMARK    GeneRIF: CELF protein activity is required for normal alternative
            splicing in the heart in vivo and normal CELF-mediated alternative
            splicing regulation is in turn required for normal cardiac
            function.
REFERENCE   7  (residues 1 to 484)
  AUTHORS   Meins M, Schlickum S, Wilhelm C, Missbach J, Yadav S, Glaser B,
            Grzmil M, Burfeind P and Laccone F.
  TITLE     Identification and characterization of murine Brunol4, a new member
            of the elav/bruno family
  JOURNAL   Cytogenet Genome Res 97 (3-4), 254-260 (2002)
   PUBMED   12438720
  REMARK    GeneRIF: cloning and characterization
REFERENCE   8  (residues 1 to 484)
  AUTHORS   Ladd AN, Charlet N and Cooper TA.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   9  (residues 1 to 484)
  AUTHORS   Good PJ, Chen Q, Warner SJ and Herring DC.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
REFERENCE   10 (residues 1 to 484)
  AUTHORS   Yulug IG, Egan SE, See CG and Fisher EM.
  TITLE     Mapping GRB2, a signal transduction gene in the human and the mouse
  JOURNAL   Genomics 22 (2), 313-318 (1994)
   PUBMED   7806216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121094.8, AK048427.1, AF515450.1, CX242398.1, AK038871.1 and
            AK078071.1.
            
            On or before Aug 8, 2019 this sequence version replaced
            NP_001349248.1, NP_573458.1.
            
            Transcript Variant: This variant (4) encodes isoform (41, also
            known as D).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK048427.1, SRR1660815.35317.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..484
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 13.92 cM"
     Protein         1..484
                     /product="CUGBP Elav-like family member 4 isoform 38"
                     /note="CUG-BP- and ETR-3-like factor 4; bruno-like protein
                     4; RNA-binding protein BRUNOL-4; bruno-like 4, RNA binding
                     protein"
                     /calculated_mol_wt=51624
     Region          18..39
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          49..135
                     /region_name="RRM1_CELF3_4_5_6"
                     /note="RNA recognition motif 1 (RRM1) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12632"
                     /db_xref="CDD:410041"
     Site            order(55,57,59..60,63,82,84,86,95..97,99,129,131)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410041"
     Region          121..149
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          150..230
                     /region_name="RRM2_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12635"
                     /db_xref="CDD:410043"
     Site            order(152,154,156..157,160,179,181,183,191..193,195,225,
                     227)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410043"
     Region          238..257
                     /region_name="Necessary for TNNT2 exon 5 inclusion.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          415..473
                     /region_name="RRM_SF"
                     /note="RNA recognition motif (RRM) superfamily; cl17169"
                     /db_xref="CDD:450164"
     CDS             1..484
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /coded_by="NM_133195.4:531..1985"
                     /note="isoform 38 is encoded by transcript variant 4"
                     /db_xref="CCDS:CCDS29106.1"
                     /db_xref="GeneID:108013"
                     /db_xref="MGI:MGI:1932407"
ORIGIN      
        1 myikmatlan gqadnaslst nglgsspgsa ghmnglshsp gnpstipmkd hdaiklfigq
       61 iprnldekdl kplfeefgki yeltvlkdrf tgmhkgcafl tyceresalk aqsalheqkt
      121 lpgmnrpiqv kpadsesrgg ssclrqppsh rklfvgmlnk qqseddvrrl feafgnieec
      181 tilrgpdgns kgcafvkyss haeaqaaina lhgsqtmpga ssslvvkfad tdkertmrrm
      241 qqmagqmgmf npmaipfgay gayaqalmqq qaalmasvaq ggylnpmaaf aaaqmqqmaa
      301 lnmnglaaap mtptsggstp pgitapavps ipspigvngf tglppqangq paaeavfang
      361 ihpypaqspt aadplqqaya gvqqyagpay paaygqisqa fpqpppmipq qqregpegcn
      421 lliyhlpqef gdaelmqmfl pfgfvsfdnp asaqtaiqam ngfqigmkrl kvqlkrpkda
      481 nrpy
//
LOCUS       NP_001349260             457 aa            linear   ROD 09-OCT-2023
DEFINITION  CUGBP Elav-like family member 4 isoform 49 [Mus musculus].
ACCESSION   NP_001349260 XP_006525579
VERSION     NP_001349260.1
DBSOURCE    REFSEQ: accession NM_001362331.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 457)
  AUTHORS   Salamon I, Park Y, Miskic T, Kopic J, Matteson P, Page NF, Roque A,
            McAuliffe GW, Favate J, Garcia-Forn M, Shah P, Judas M, Millonig
            JH, Kostovic I, De Rubeis S, Hart RP, Krsnik Z and Rasin MR.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    GeneRIF: Celf4 controls mRNA translation underlying synaptic
            development in the prenatal mammalian neocortex.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 457)
  AUTHORS   Shen Y, Zhang C, Xiao K, Liu D and Xie G.
  TITLE     CELF4 regulates spine formation and depression-like behaviors of
            mice
  JOURNAL   Biochem Biophys Res Commun 605, 39-44 (2022)
   PUBMED   35306363
  REMARK    GeneRIF: CELF4 regulates spine formation and depression-like
            behaviors of mice.
REFERENCE   3  (residues 1 to 457)
  AUTHORS   Moreau MX, Saillour Y, Cwetsch AW, Pierani A and Causeret F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   4  (residues 1 to 457)
  AUTHORS   Li C, Li X, Bi Z, Sugino K, Wang G, Zhu T and Liu Z.
  TITLE     Comprehensive transcriptome analysis of cochlear spiral ganglion
            neurons at multiple ages
  JOURNAL   Elife 9, e50491 (2020)
   PUBMED   31913118
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 457)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 457)
  AUTHORS   Ladd AN, Taffet G, Hartley C, Kearney DL and Cooper TA.
  TITLE     Cardiac tissue-specific repression of CELF activity disrupts
            alternative splicing and causes cardiomyopathy
  JOURNAL   Mol Cell Biol 25 (14), 6267-6278 (2005)
   PUBMED   15988035
  REMARK    GeneRIF: CELF protein activity is required for normal alternative
            splicing in the heart in vivo and normal CELF-mediated alternative
            splicing regulation is in turn required for normal cardiac
            function.
REFERENCE   7  (residues 1 to 457)
  AUTHORS   Meins M, Schlickum S, Wilhelm C, Missbach J, Yadav S, Glaser B,
            Grzmil M, Burfeind P and Laccone F.
  TITLE     Identification and characterization of murine Brunol4, a new member
            of the elav/bruno family
  JOURNAL   Cytogenet Genome Res 97 (3-4), 254-260 (2002)
   PUBMED   12438720
  REMARK    GeneRIF: cloning and characterization
REFERENCE   8  (residues 1 to 457)
  AUTHORS   Ladd AN, Charlet N and Cooper TA.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   9  (residues 1 to 457)
  AUTHORS   Good PJ, Chen Q, Warner SJ and Herring DC.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
REFERENCE   10 (residues 1 to 457)
  AUTHORS   Yulug IG, Egan SE, See CG and Fisher EM.
  TITLE     Mapping GRB2, a signal transduction gene in the human and the mouse
  JOURNAL   Genomics 22 (2), 313-318 (1994)
   PUBMED   7806216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121094.8 and AC144938.3.
            
            On Apr 12, 2018 this sequence version replaced XP_006525579.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660821.184792.1,
                                           SRR1660817.87104.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..457
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 13.92 cM"
     Protein         1..457
                     /product="CUGBP Elav-like family member 4 isoform 49"
                     /note="CUG-BP- and ETR-3-like factor 4; bruno-like protein
                     4; RNA-binding protein BRUNOL-4; bruno-like 4, RNA binding
                     protein"
                     /calculated_mol_wt=48538
     Region          49..135
                     /region_name="RRM1_CELF3_4_5_6"
                     /note="RNA recognition motif 1 (RRM1) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12632"
                     /db_xref="CDD:410041"
     Site            order(55,57,59..60,63,82,84,86,95..97,99,129,131)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410041"
     Region          <56..378
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     Region          151..231
                     /region_name="RRM2_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12635"
                     /db_xref="CDD:410043"
     Site            order(153,155,157..158,161,180,182,184,192..194,196,226,
                     228)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410043"
     Region          <416..456
                     /region_name="RRM_SF"
                     /note="RNA recognition motif (RRM) superfamily; cl17169"
                     /db_xref="CDD:450164"
     CDS             1..457
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /coded_by="NM_001362331.1:531..1904"
                     /note="isoform 49 is encoded by transcript variant 51"
                     /db_xref="GeneID:108013"
                     /db_xref="MGI:MGI:1932407"
ORIGIN      
        1 myikmatlan gqadnaslst nglgsspgsa ghmnglshsp gnpstipmkd hdaiklfigq
       61 iprnldekdl kplfeefgki yeltvlkdrf tgmhkgcafl tyceresalk aqsalheqkt
      121 lpgmnrpiqv kpadsesrgg ssclrqppsq drklfvgmln kqqseddvrr lfeafgniee
      181 ctilrgpdgn skgcafvkys shaeaqaain alhgsqtmpg assslvvkfa dtdkertmrr
      241 mqqmagqmgm fnpmaipfga ygayaqalmq qqaalmasva qggylnpmaa faaaqmqqma
      301 alnmnglaaa pmtptsggst ppgitapavp sipspigvng ftglppqang qpaaeavfan
      361 gihpypaqsp taadplqqay agvqqyagpa ypaaygqisq afpqpppmip qqqregfvsf
      421 dnpasaqtai qamngfqigm krlkvqlkrp kdanrpy
//
LOCUS       NP_001397150             546 aa            linear   ROD 09-OCT-2023
DEFINITION  nuclear respiratory factor 1 isoform g [Mus musculus].
ACCESSION   NP_001397150 XP_006505068
VERSION     NP_001397150.1
DBSOURCE    REFSEQ: accession NM_001410221.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 546)
  AUTHORS   Cheng C, Tian Y, Yang R, Guo W, Xiao K, Zhang F, Tian J, Deng Z,
            Yang W, Yang H and Zhou Z.
  TITLE     miR-5581 Contributes to Osteoarthritis by Targeting NRF1 to Disturb
            the Proliferation and Functions of Chondrocytes
  JOURNAL   Am J Pathol 193 (9), 1234-1247 (2023)
   PUBMED   37611970
  REMARK    GeneRIF: miR-5581 Contributes to Osteoarthritis by Targeting NRF1
            to Disturb the Proliferation and Functions of Chondrocytes.
REFERENCE   2  (residues 1 to 546)
  AUTHORS   Meng Z, Liang B, Wu Y, Liu C, Wang H, Du Y, Gan L, Gao E, Lau WB,
            Christopher TA, Lopez BL, Koch WJ, Ma X, Zhao F, Wang Y and Zhao J.
  TITLE     Hypoadiponectinemia-induced upregulation of microRNA449b
            downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury
            in diabetic mice
  JOURNAL   J Mol Cell Cardiol 182, 1-14 (2023)
   PUBMED   37437402
  REMARK    GeneRIF: Hypoadiponectinemia-induced upregulation of microRNA449b
            downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury
            in diabetic mice.
REFERENCE   3  (residues 1 to 546)
  AUTHORS   Zhao T, Zhang J, Lei H, Meng Y, Cheng H, Zhao Y, Geng G, Mu C, Chen
            L, Liu Q, Luo Q, Zhang C, Long Y, Su J, Wang Y, Li Z, Sun J, Chen
            G, Li Y, Liao X, Shang Y, Hu G, Chen Q and Zhu Y.
  TITLE     NRF1-mediated mitochondrial biogenesis antagonizes innate antiviral
            immunity
  JOURNAL   EMBO J 42 (16), e113258 (2023)
   PUBMED   37409632
  REMARK    GeneRIF: NRF1-mediated mitochondrial biogenesis antagonizes innate
            antiviral immunity.
REFERENCE   4  (residues 1 to 546)
  AUTHORS   Akl MG, Baccetto R, Stebbings BM, Li L and Widenmaier SB.
  TITLE     Euglycemia is affected by stress defense factor hepatocyte NRF1,
            but not NRF2
  JOURNAL   Biochem Biophys Res Commun 668, 96-103 (2023)
   PUBMED   37245295
  REMARK    GeneRIF: Euglycemia is affected by stress defense factor hepatocyte
            NRF1, but not NRF2.
REFERENCE   5  (residues 1 to 546)
  AUTHORS   Akl MG, Li L, Baccetto R, Phanse S, Zhang Q, Trites MJ, McDonald S,
            Aoki H, Babu M and Widenmaier SB.
  TITLE     Complementary gene regulation by NRF1 and NRF2 protects against
            hepatic cholesterol overload
  JOURNAL   Cell Rep 42 (4), 112399 (2023)
   PUBMED   37060561
  REMARK    GeneRIF: Complementary gene regulation by NRF1 and NRF2 protects
            against hepatic cholesterol overload.
            Erratum:[Cell Rep. 2023 Jul 25;42(7):112872. PMID: 37454293]
REFERENCE   6  (residues 1 to 546)
  AUTHORS   Carmona MC, Iglesias R, Obregon MJ, Darlington GJ, Villarroya F and
            Giralt M.
  TITLE     Mitochondrial biogenesis and thyroid status maturation in brown fat
            require CCAAT/enhancer-binding protein alpha
  JOURNAL   J Biol Chem 277 (24), 21489-21498 (2002)
   PUBMED   11940593
REFERENCE   7  (residues 1 to 546)
  AUTHORS   Huo L and Scarpulla RC.
  TITLE     Mitochondrial DNA instability and peri-implantation lethality
            associated with targeted disruption of nuclear respiratory factor 1
            in mice
  JOURNAL   Mol Cell Biol 21 (2), 644-654 (2001)
   PUBMED   11134350
REFERENCE   8  (residues 1 to 546)
  AUTHORS   Schaefer L, Engman H and Miller JB.
  TITLE     Coding sequence, chromosomal localization, and expression pattern
            of Nrf1: the mouse homolog of Drosophila erect wing
  JOURNAL   Mamm Genome 11 (2), 104-110 (2000)
   PUBMED   10656923
REFERENCE   9  (residues 1 to 546)
  AUTHORS   Huo L and Scarpulla RC.
  TITLE     Multiple 5'-untranslated exons in the nuclear respiratory factor 1
            gene span 47 kb and contribute to transcript heterogeneity and
            translational efficiency
  JOURNAL   Gene 233 (1-2), 213-224 (1999)
   PUBMED   10375638
REFERENCE   10 (residues 1 to 546)
  AUTHORS   Virbasius CA, Virbasius JV and Scarpulla RC.
  TITLE     NRF-1, an activator involved in nuclear-mitochondrial interactions,
            utilizes a new DNA-binding domain conserved in a family of
            developmental regulators
  JOURNAL   Genes Dev 7 (12A), 2431-2445 (1993)
   PUBMED   8253388
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134897.4 and AC153632.2.
            
            On Aug 1, 2022 this sequence version replaced XP_006505068.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422601.2370566.1,
                                           SRR13422597.1325606.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..546
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 12.47 cM"
     Protein         1..546
                     /product="nuclear respiratory factor 1 isoform g"
                     /note="NRF-1; alpha-pal; alpha palindromic-binding
                     protein"
                     /calculated_mol_wt=58438
     Region          87..295
                     /region_name="Nrf1_DNA-bind"
                     /note="NLS-binding and DNA-binding and dimerization
                     domains of Nrf1; pfam10491"
                     /db_xref="CDD:402218"
     Region          462..537
                     /region_name="TGS_YchF_OLA1"
                     /note="TGS (ThrRS, GTPase and SpoT) domain found in the
                     YchF/OLA1 family proteins; cd04867"
                     /db_xref="CDD:340516"
     Site            519
                     /site_type="other"
                     /note="key conserved lysine K48"
                     /db_xref="CDD:340516"
     CDS             1..546
                     /gene="Nrf1"
                     /gene_synonym="D6Ertd415e"
                     /coded_by="NM_001410221.1:271..1911"
                     /note="isoform g is encoded by transcript variant 11"
                     /db_xref="GeneID:18181"
                     /db_xref="MGI:MGI:1332235"
ORIGIN      
        1 meehgvtqte hmatieahav aqqvqqvhva tytehsmlsa dedspssped tsyddsdiln
       61 staadevtah laaavlgikp rashilgpvg maaaaavatg kkrkrphvfe snpsirkrqq
      121 trllrklrat ldeyttrvgq qaivlcisps kpnpvfkvfg aaplenvvrk yksmiledle
      181 salaehapap qevnselppl tidgipvsvd kmtqaqlraf ipemlkystg rgkpgwgkes
      241 ckpiwwpedi pwanvrsdvr teeqkqrvsw tqalrtivkn cykqhgredl lyafedqqtq
      301 tqattthsia hlvpsqtvvq tfsnpdgtvs liqvgtgatv atladaselp ttvtvaqvny
      361 savadgeveq nwatlqggem tiqttqasea tqavaslaea avaasqemqq gatvtmalns
      421 eaaahavatl aeatlqgggq ivlsgetaaa vgaltgvqda ngpdgvhawt iskavtapqa
      481 agkihtdfgk gfimaevmkd edlkeessen aakaagkykq qgrayvvedg diiffkfnsp
      541 qqlkkk
//
LOCUS       NP_033268                302 aa            linear   ROD 09-OCT-2023
DEFINITION  SPARC precursor [Mus musculus].
ACCESSION   NP_033268 XP_916834
VERSION     NP_033268.1
DBSOURCE    REFSEQ: accession NM_009242.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 302)
  AUTHORS   Ryu S, Spadaro O, Sidorov S, Lee AH, Caprio S, Morrison C, Smith
            SR, Ravussin E, Shchukina I, Artyomov MN, Youm YH and Dixit VD.
  TITLE     Reduction of SPARC protects mice against NLRP3 inflammasome
            activation and obesity
  JOURNAL   J Clin Invest 133 (19), e169173 (2023)
   PUBMED   37781916
  REMARK    GeneRIF: Reduction of SPARC protects mice against NLRP3
            inflammasome activation and obesity.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 302)
  AUTHORS   Pina JO, Raju R, Roth DM, Winchester EW, Chattaraj P, Kidwai F,
            Faucz FR, Iben J, Mitra A, Campbell K, Fridell G, Esnault C, Cotney
            JL, Dale RK and D'Souza RN.
  TITLE     Multimodal spatiotemporal transcriptomic resolution of embryonic
            palate osteogenesis
  JOURNAL   Nat Commun 14 (1), 5687 (2023)
   PUBMED   37709732
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 302)
  AUTHORS   Feldt J, Garriz A, Rodriguez Benavente MC, Woodward AM, Zoukhri D
            and Argueso P.
  TITLE     The Matricellular Protein SPARC Decreases in the Lacrimal Gland At
            Adulthood and During Inflammation
  JOURNAL   Invest Ophthalmol Vis Sci 63 (13), 8 (2022)
   PUBMED   36479944
  REMARK    GeneRIF: The Matricellular Protein SPARC Decreases in the Lacrimal
            Gland At Adulthood and During Inflammation.
REFERENCE   4  (residues 1 to 302)
  AUTHORS   Mathes S, Fahrner A, Luca E and Krutzfeldt J.
  TITLE     Growth hormone/IGF-I-dependent signaling restores decreased
            expression of the myokine SPARC in aged skeletal muscle
  JOURNAL   J Mol Med (Berl) 100 (11), 1647-1658 (2022)
   PUBMED   36178526
  REMARK    GeneRIF: Growth hormone/IGF-I-dependent signaling restores
            decreased expression of the myokine SPARC in aged skeletal muscle.
REFERENCE   5  (residues 1 to 302)
  AUTHORS   Ryu S, Sidorov S, Ravussin E, Artyomov M, Iwasaki A, Wang A and
            Dixit VD.
  TITLE     The matricellular protein SPARC induces inflammatory
            interferon-response in macrophages during aging
  JOURNAL   Immunity 55 (9), 1609-1626 (2022)
   PUBMED   35963236
REFERENCE   6  (residues 1 to 302)
  AUTHORS   Baron B, Poirier C, Simon-Chazottes D, Barnier C and Guenet JL.
  TITLE     A new strategy useful for rapid identification of microsatellites
            from DNA libraries with large size inserts
  JOURNAL   Nucleic Acids Res 20 (14), 3665-3669 (1992)
   PUBMED   1386425
REFERENCE   7  (residues 1 to 302)
  AUTHORS   Bloom ML, Lee BK, Birkenmeier CS, Ma Y, Zimmer WE, Goodman SR,
            Eicher EM and Barker JE.
  TITLE     Brain beta spectrin isoform 235 (Spnb-2) maps to mouse chromosome
            11
  JOURNAL   Mamm Genome 3 (5), 293-295 (1992)
   PUBMED   1638088
REFERENCE   8  (residues 1 to 302)
  AUTHORS   Le Roy H, Simon-Chazottes D, Montagutelli X and Guenet JL.
  TITLE     A set of anonymous DNA clones as markers for mouse gene mapping
  JOURNAL   Mamm Genome 3 (4), 244-246 (1992)
   PUBMED   1351769
REFERENCE   9  (residues 1 to 302)
  AUTHORS   Baldacci PA, Richoux V, Renard JP, Guenet JL and Babinet C.
  TITLE     The locus Om, responsible for the DDK syndrome, maps close to Sigje
            on mouse chromosome 11
  JOURNAL   Mamm Genome 2 (2), 100-105 (1992)
   PUBMED   1347470
REFERENCE   10 (residues 1 to 302)
  AUTHORS   Buckwalter MS, Katz RW and Camper SA.
  TITLE     Localization of the panhypopituitary dwarf mutation (df) on mouse
            chromosome 11 in an intersubspecific backcross
  JOURNAL   Genomics 10 (3), 515-526 (1991)
   PUBMED   1889803
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY781653.1, BB857564.1, AK161229.1, AA798908.1, CJ132527.1 and
            BE655213.1.
            
            On Dec 7, 2005 this sequence version replaced XP_916834.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.15933.1,
                                           SRR1660811.202887.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849388
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..302
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 33.04 cM"
     Protein         1..302
                     /product="SPARC precursor"
                     /note="basement-membrane protein 40; secreted protein
                     acidic and rich in cysteine; osteonectin"
                     /calculated_mol_wt=32516
     sig_peptide     1..17
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=1952
     Region          70..151
                     /region_name="FSL_SPARC"
                     /note="Follistatin-like SPARC (secreted protein, acidic,
                     and rich in cysteines) domain; SPARC/BM-40/osteonectin is
                     a multifunctional glycoprotein which modulates cellular
                     interaction with the extracellular matrix by its binding
                     to structural matrix proteins...; cd01328"
                     /db_xref="CDD:238649"
     Site            115
                     /site_type="other"
                     /note="N-glycosylation site [posttranslational
                     modification]"
                     /db_xref="CDD:238649"
     Site            115
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000305|PubMed:3427055; propagated from
                     UniProtKB/Swiss-Prot (P07214.1)"
     Region          154..293
                     /region_name="EFh_SPARC_SPARC"
                     /note="EF-hand, extracellular calcium-binding (EC) motif,
                     found in secreted protein acidic and rich in cysteine
                     (SPARC); cd16235"
                     /db_xref="CDD:320014"
     Site            order(161..162,165..166,168..169,172..173,176,180,258,
                     261..262)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:320014"
     Region          226..259
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320014"
     Site            order(238,243,250,273,275,277,284)
                     /site_type="other"
                     /note="Ca binding site [ion binding]"
                     /db_xref="CDD:320014"
     Site            order(248..249,263)
                     /site_type="other"
                     /note="EC/FS-domain interface"
                     /db_xref="CDD:320014"
     Region          261..293
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320014"
     CDS             1..302
                     /gene="Sparc"
                     /gene_synonym="BM-40; ON"
                     /coded_by="NM_009242.5:307..1215"
                     /db_xref="CCDS:CCDS24712.1"
                     /db_xref="GeneID:20692"
                     /db_xref="MGI:MGI:98373"
ORIGIN      
        1 mrawiffllc lagralaapq qtevaeeive eetvveetgv pvganpvqve mgefedgaee
       61 tveevvadnp cqnhhckhgk vceldesntp mcvcqdptsc papigefekv csndnktfds
      121 schffatkct legtkkghkl hldyigpcky iapcldselt efplrmrdwl knvlvtlyer
      181 degnnlltek qklrvkkihe nekrleagdh pvellardfe knynmyifpv hwqfgqldqh
      241 pidgylshte laplraplip mehcttrffe tcdldndkyi aleewagcfg ikeqdinkdl
      301 vi
//
LOCUS       NP_001349218             524 aa            linear   ROD 09-OCT-2023
DEFINITION  CUGBP Elav-like family member 4 isoform 14 [Mus musculus].
ACCESSION   NP_001349218 XP_017173279
VERSION     NP_001349218.1
DBSOURCE    REFSEQ: accession NM_001362289.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 524)
  AUTHORS   Salamon I, Park Y, Miskic T, Kopic J, Matteson P, Page NF, Roque A,
            McAuliffe GW, Favate J, Garcia-Forn M, Shah P, Judas M, Millonig
            JH, Kostovic I, De Rubeis S, Hart RP, Krsnik Z and Rasin MR.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    GeneRIF: Celf4 controls mRNA translation underlying synaptic
            development in the prenatal mammalian neocortex.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 524)
  AUTHORS   Shen Y, Zhang C, Xiao K, Liu D and Xie G.
  TITLE     CELF4 regulates spine formation and depression-like behaviors of
            mice
  JOURNAL   Biochem Biophys Res Commun 605, 39-44 (2022)
   PUBMED   35306363
  REMARK    GeneRIF: CELF4 regulates spine formation and depression-like
            behaviors of mice.
REFERENCE   3  (residues 1 to 524)
  AUTHORS   Moreau MX, Saillour Y, Cwetsch AW, Pierani A and Causeret F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   4  (residues 1 to 524)
  AUTHORS   Li C, Li X, Bi Z, Sugino K, Wang G, Zhu T and Liu Z.
  TITLE     Comprehensive transcriptome analysis of cochlear spiral ganglion
            neurons at multiple ages
  JOURNAL   Elife 9, e50491 (2020)
   PUBMED   31913118
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 524)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 524)
  AUTHORS   Ladd AN, Taffet G, Hartley C, Kearney DL and Cooper TA.
  TITLE     Cardiac tissue-specific repression of CELF activity disrupts
            alternative splicing and causes cardiomyopathy
  JOURNAL   Mol Cell Biol 25 (14), 6267-6278 (2005)
   PUBMED   15988035
  REMARK    GeneRIF: CELF protein activity is required for normal alternative
            splicing in the heart in vivo and normal CELF-mediated alternative
            splicing regulation is in turn required for normal cardiac
            function.
REFERENCE   7  (residues 1 to 524)
  AUTHORS   Meins M, Schlickum S, Wilhelm C, Missbach J, Yadav S, Glaser B,
            Grzmil M, Burfeind P and Laccone F.
  TITLE     Identification and characterization of murine Brunol4, a new member
            of the elav/bruno family
  JOURNAL   Cytogenet Genome Res 97 (3-4), 254-260 (2002)
   PUBMED   12438720
  REMARK    GeneRIF: cloning and characterization
REFERENCE   8  (residues 1 to 524)
  AUTHORS   Ladd AN, Charlet N and Cooper TA.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   9  (residues 1 to 524)
  AUTHORS   Good PJ, Chen Q, Warner SJ and Herring DC.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
REFERENCE   10 (residues 1 to 524)
  AUTHORS   Yulug IG, Egan SE, See CG and Fisher EM.
  TITLE     Mapping GRB2, a signal transduction gene in the human and the mouse
  JOURNAL   Genomics 22 (2), 313-318 (1994)
   PUBMED   7806216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121094.8 and AC144938.3.
            
            On Apr 12, 2018 this sequence version replaced XP_017173279.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660819.174716.1,
                                           SRR7652917.344998.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..524
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 13.92 cM"
     Protein         1..524
                     /product="CUGBP Elav-like family member 4 isoform 14"
                     /note="CUG-BP- and ETR-3-like factor 4; bruno-like protein
                     4; RNA-binding protein BRUNOL-4; bruno-like 4, RNA binding
                     protein"
                     /calculated_mol_wt=55794
     Region          49..135
                     /region_name="RRM1_CELF3_4_5_6"
                     /note="RNA recognition motif 1 (RRM1) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12632"
                     /db_xref="CDD:410041"
     Site            order(55,57,59..60,63,82,84,86,95..97,99,129,131)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410041"
     Region          140..220
                     /region_name="RRM2_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12635"
                     /db_xref="CDD:410043"
     Site            order(142,144,146..147,150,169,171,173,181..183,185,215,
                     217)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410043"
     Region          405..>433
                     /region_name="RRM_SF"
                     /note="RNA recognition motif (RRM) superfamily; cl17169"
                     /db_xref="CDD:450164"
     CDS             1..524
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /coded_by="NM_001362289.1:531..2105"
                     /note="isoform 14 is encoded by transcript variant 20"
                     /db_xref="GeneID:108013"
                     /db_xref="MGI:MGI:1932407"
ORIGIN      
        1 myikmatlan gqadnaslst nglgsspgsa ghmnglshsp gnpstipmkd hdaiklfigq
       61 iprnldekdl kplfeefgki yeltvlkdrf tgmhkgcafl tyceresalk aqsalheqkt
      121 lpgmnrpiqv kpadsesrgd rklfvgmlnk qqseddvrrl feafgnieec tilrgpdgns
      181 kgcafvkyss haeaqaaina lhgsqtmpga ssslvvkfad tdkertmrrm qqmagqmgmf
      241 npmaipfgay gayaqalmqq qaalmasvaq ggylnpmaaf aaaqmqqmaa lnmnglaaap
      301 mtptsggstp pgitapavps ipspigvngf tglppqangq paaeavfang ihpypaqspt
      361 aadplqqaya gvqqyagpay paaygqisqa fpqpppmipq qqregpegcn lliyhlpqef
      421 gdaelmqmfl pfgrhpvpsr cqapscqggq caisssarrl relrqpgqrt drhpgherlp
      481 drheeaqgaa eaaqrrqspv lsaggsvprg rpglaqgrml nglh
//
LOCUS       NP_001157702             519 aa            linear   ROD 09-OCT-2023
DEFINITION  nuclear respiratory factor 1 isoform e [Mus musculus].
ACCESSION   NP_001157702
VERSION     NP_001157702.1
DBSOURCE    REFSEQ: accession NM_001164230.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 519)
  AUTHORS   Cheng C, Tian Y, Yang R, Guo W, Xiao K, Zhang F, Tian J, Deng Z,
            Yang W, Yang H and Zhou Z.
  TITLE     miR-5581 Contributes to Osteoarthritis by Targeting NRF1 to Disturb
            the Proliferation and Functions of Chondrocytes
  JOURNAL   Am J Pathol 193 (9), 1234-1247 (2023)
   PUBMED   37611970
  REMARK    GeneRIF: miR-5581 Contributes to Osteoarthritis by Targeting NRF1
            to Disturb the Proliferation and Functions of Chondrocytes.
REFERENCE   2  (residues 1 to 519)
  AUTHORS   Meng Z, Liang B, Wu Y, Liu C, Wang H, Du Y, Gan L, Gao E, Lau WB,
            Christopher TA, Lopez BL, Koch WJ, Ma X, Zhao F, Wang Y and Zhao J.
  TITLE     Hypoadiponectinemia-induced upregulation of microRNA449b
            downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury
            in diabetic mice
  JOURNAL   J Mol Cell Cardiol 182, 1-14 (2023)
   PUBMED   37437402
  REMARK    GeneRIF: Hypoadiponectinemia-induced upregulation of microRNA449b
            downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury
            in diabetic mice.
REFERENCE   3  (residues 1 to 519)
  AUTHORS   Zhao T, Zhang J, Lei H, Meng Y, Cheng H, Zhao Y, Geng G, Mu C, Chen
            L, Liu Q, Luo Q, Zhang C, Long Y, Su J, Wang Y, Li Z, Sun J, Chen
            G, Li Y, Liao X, Shang Y, Hu G, Chen Q and Zhu Y.
  TITLE     NRF1-mediated mitochondrial biogenesis antagonizes innate antiviral
            immunity
  JOURNAL   EMBO J 42 (16), e113258 (2023)
   PUBMED   37409632
  REMARK    GeneRIF: NRF1-mediated mitochondrial biogenesis antagonizes innate
            antiviral immunity.
REFERENCE   4  (residues 1 to 519)
  AUTHORS   Akl MG, Baccetto R, Stebbings BM, Li L and Widenmaier SB.
  TITLE     Euglycemia is affected by stress defense factor hepatocyte NRF1,
            but not NRF2
  JOURNAL   Biochem Biophys Res Commun 668, 96-103 (2023)
   PUBMED   37245295
  REMARK    GeneRIF: Euglycemia is affected by stress defense factor hepatocyte
            NRF1, but not NRF2.
REFERENCE   5  (residues 1 to 519)
  AUTHORS   Akl MG, Li L, Baccetto R, Phanse S, Zhang Q, Trites MJ, McDonald S,
            Aoki H, Babu M and Widenmaier SB.
  TITLE     Complementary gene regulation by NRF1 and NRF2 protects against
            hepatic cholesterol overload
  JOURNAL   Cell Rep 42 (4), 112399 (2023)
   PUBMED   37060561
  REMARK    GeneRIF: Complementary gene regulation by NRF1 and NRF2 protects
            against hepatic cholesterol overload.
            Erratum:[Cell Rep. 2023 Jul 25;42(7):112872. PMID: 37454293]
REFERENCE   6  (residues 1 to 519)
  AUTHORS   Carmona MC, Iglesias R, Obregon MJ, Darlington GJ, Villarroya F and
            Giralt M.
  TITLE     Mitochondrial biogenesis and thyroid status maturation in brown fat
            require CCAAT/enhancer-binding protein alpha
  JOURNAL   J Biol Chem 277 (24), 21489-21498 (2002)
   PUBMED   11940593
REFERENCE   7  (residues 1 to 519)
  AUTHORS   Huo L and Scarpulla RC.
  TITLE     Mitochondrial DNA instability and peri-implantation lethality
            associated with targeted disruption of nuclear respiratory factor 1
            in mice
  JOURNAL   Mol Cell Biol 21 (2), 644-654 (2001)
   PUBMED   11134350
REFERENCE   8  (residues 1 to 519)
  AUTHORS   Schaefer L, Engman H and Miller JB.
  TITLE     Coding sequence, chromosomal localization, and expression pattern
            of Nrf1: the mouse homolog of Drosophila erect wing
  JOURNAL   Mamm Genome 11 (2), 104-110 (2000)
   PUBMED   10656923
REFERENCE   9  (residues 1 to 519)
  AUTHORS   Huo L and Scarpulla RC.
  TITLE     Multiple 5'-untranslated exons in the nuclear respiratory factor 1
            gene span 47 kb and contribute to transcript heterogeneity and
            translational efficiency
  JOURNAL   Gene 233 (1-2), 213-224 (1999)
   PUBMED   10375638
REFERENCE   10 (residues 1 to 519)
  AUTHORS   Virbasius CA, Virbasius JV and Scarpulla RC.
  TITLE     NRF-1, an activator involved in nuclear-mitochondrial interactions,
            utilizes a new DNA-binding domain conserved in a family of
            developmental regulators
  JOURNAL   Genes Dev 7 (12A), 2431-2445 (1993)
   PUBMED   8253388
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134897.4 and AC153632.2.
            
            Transcript Variant: This variant (5) uses an alternate splice site
            in the 5' UTR and contains an alternate exon in the 3' coding
            region which results in a frameshift and early stop codon, compared
            to variant 1. This results in a distinct and shorter C-terminus in
            isoform e, compared to isoform a. Variants 5 and 16 both encode the
            same isoform (e).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253011.3125907.1,
                                           SRR17253012.1140558.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..519
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 12.47 cM"
     Protein         1..519
                     /product="nuclear respiratory factor 1 isoform e"
                     /note="NRF-1; alpha-pal; alpha palindromic-binding
                     protein"
                     /calculated_mol_wt=55677
     Region          1..78
                     /region_name="Dimerization. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU00.2)"
     Region          36..57
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU00.2)"
     Site            39
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:Q16656; propagated from
                     UniProtKB/Swiss-Prot (Q9WU00.2)"
     Site            44
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:Q16656; propagated from
                     UniProtKB/Swiss-Prot (Q9WU00.2)"
     Site            46
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:Q16656; propagated from
                     UniProtKB/Swiss-Prot (Q9WU00.2)"
     Site            47
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:Q16656; propagated from
                     UniProtKB/Swiss-Prot (Q9WU00.2)"
     Site            52
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:Q16656; propagated from
                     UniProtKB/Swiss-Prot (Q9WU00.2)"
     Region          87..283
                     /region_name="Nrf1_DNA-bind"
                     /note="NLS-binding and DNA-binding and dimerization
                     domains of Nrf1; pfam10491"
                     /db_xref="CDD:402218"
     Region          88..116
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU00.2)"
     CDS             1..519
                     /gene="Nrf1"
                     /gene_synonym="D6Ertd415e"
                     /coded_by="NM_001164230.2:271..1830"
                     /note="isoform e is encoded by transcript variant 5"
                     /db_xref="CCDS:CCDS51740.1"
                     /db_xref="GeneID:18181"
                     /db_xref="MGI:MGI:1332235"
ORIGIN      
        1 meehgvtqte hmatieahav aqqvqqvhva tytehsmlsa dedspssped tsyddsdiln
       61 staadevtah laaagpvgma aaaavatgkk rkrphvfesn psirkrqqtr llrklratld
      121 eyttrvgqqa ivlcispskp npvfkvfgaa plenvvrkyk smiledlesa laehapapqe
      181 vnselpplti dgipvsvdkm tqaqlrafip emlkystgrg kpgwgkesck piwwpedipw
      241 anvrsdvrte eqkqrvswtq alrtivkncy kqhgredlly afedqqtqtq attthsiahl
      301 vpsqtvvqtf snpdgtvsli qvgtgatvat ladaselptt vtvaqvnysa vadgeveqnw
      361 atlqggemti qttqaseatq avaslaeaav aasqemqqga tvtmalnsea aahavatlae
      421 atlqgggqiv lsgetaaavg altgvqdang lgspvlpeim asktrgyrhs cgrdlyrlfs
      481 ffllysknne rillapatsg spcfyvrnii tirvgilss
//
LOCUS       NP_001277685            1050 aa            linear   ROD 09-OCT-2023
DEFINITION  toll-like receptor 7 isoform a precursor [Mus musculus].
ACCESSION   NP_001277685 XP_006528779
VERSION     NP_001277685.1
DBSOURCE    REFSEQ: accession NM_001290756.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1050)
  AUTHORS   Huang Y, Liu D, Chen M, Xu S, Peng Q, Zhu Y, Long J, Liu T, Deng Z,
            Xie H, Li J, Liu F and Xiao W.
  TITLE     TLR7 promotes skin inflammation via activating NFkappaB-mTORC1 axis
            in rosacea
  JOURNAL   PeerJ 11, e15976 (2023)
   PUBMED   37780385
  REMARK    GeneRIF: TLR7 promotes skin inflammation via activating
            NFkappaB-mTORC1 axis in rosacea.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1050)
  AUTHORS   Miles MA, Liong S, Liong F, Coward-Smith M, Trollope GS, Oseghale
            O, Erlich JR, Brooks RD, Logan JM, Hickey S, Wang H, Bozinovski S,
            O'Leary JJ, Brooks DA and Selemidis S.
  TITLE     TLR7 promotes chronic airway disease in RSV-infected mice
  JOURNAL   Front Immunol 14, 1240552 (2023)
   PUBMED   37795093
  REMARK    GeneRIF: TLR7 promotes chronic airway disease in RSV-infected mice.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1050)
  AUTHORS   Cosgrove HA, Gingras S, Kim M, Bastacky S, Tilstra JS and Shlomchik
            MJ.
  TITLE     B cell-intrinsic TLR7 expression drives severe lupus in
            TLR9-deficient mice
  JOURNAL   JCI Insight 8 (16), e172219 (2023)
   PUBMED   37606042
  REMARK    GeneRIF: B cell-intrinsic TLR7 expression drives severe lupus in
            TLR9-deficient mice.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1050)
  AUTHORS   Kim J, Ha S, Son M, Kim D, Kim MJ, Kim B, Kim D, Chung HY and Chung
            KW.
  TITLE     TLR7 activation by miR-21 promotes renal fibrosis by activating the
            pro-inflammatory signaling pathway in tubule epithelial cells
  JOURNAL   Cell Commun Signal 21 (1), 215 (2023)
   PUBMED   37596656
  REMARK    GeneRIF: TLR7 activation by miR-21 promotes renal fibrosis by
            activating the pro-inflammatory signaling pathway in tubule
            epithelial cells.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1050)
  AUTHORS   Jackson WD, Giacomassi C, Ward S, Owen A, Luis TC, Spear S,
            Woollard KJ, Johansson C, Strid J and Botto M.
  TITLE     TLR7 activation at epithelial barriers promotes emergency
            myelopoiesis and lung antiviral immunity
  JOURNAL   Elife 12, e85647 (2023)
   PUBMED   37566453
  REMARK    GeneRIF: TLR7 activation at epithelial barriers promotes emergency
            myelopoiesis and lung antiviral immunity.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1050)
  AUTHORS   Heil F, Hemmi H, Hochrein H, Ampenberger F, Kirschning C, Akira S,
            Lipford G, Wagner H and Bauer S.
  TITLE     Species-specific recognition of single-stranded RNA via toll-like
            receptor 7 and 8
  JOURNAL   Science 303 (5663), 1526-1529 (2004)
   PUBMED   14976262
  REMARK    GeneRIF: mediates species-specific recognition of GU-rich
            single-stranded RNA (ssRNA); data suggest that ssRNA represents a
            physiological ligand for TLR7
REFERENCE   7  (residues 1 to 1050)
  AUTHORS   Diebold SS, Kaisho T, Hemmi H, Akira S and Reis e Sousa C.
  TITLE     Innate antiviral responses by means of TLR7-mediated recognition of
            single-stranded RNA
  JOURNAL   Science 303 (5663), 1529-1531 (2004)
   PUBMED   14976261
  REMARK    GeneRIF: results identify ssRNA as a ligand for TLR7 and suggest
            that cells of the innate immune system sense endosomal ssRNA to
            detect infection by RNA viruses
REFERENCE   8  (residues 1 to 1050)
  AUTHORS   Pinhal-Enfield G, Ramanathan M, Hasko G, Vogel SN, Salzman AL,
            Boons GJ and Leibovich SJ.
  TITLE     An angiogenic switch in macrophages involving synergy between
            Toll-like receptors 2, 4, 7, and 9 and adenosine A(2A) receptors
  JOURNAL   Am J Pathol 163 (2), 711-721 (2003)
   PUBMED   12875990
  REMARK    GeneRIF: Results suggest novel signaling pathway in murine
            macrophages involving synergy between toll-like receptors 2, 4, 7,
            and 9 and adenosine A(2A)receptors, that up-regulates VEGF and
            down-regulates TNFalpha expression, thus acting as an angiogenic
            switch.
REFERENCE   9  (residues 1 to 1050)
  AUTHORS   Jurk,M., Heil,F., Vollmer,J., Schetter,C., Krieg,A.M., Wagner,H.,
            Lipford,G. and Bauer,S.
  TITLE     Human TLR7 or TLR8 independently confer responsiveness to the
            antiviral compound R-848
  JOURNAL   Nat Immunol 3 (6), 499 (2002)
   PUBMED   12032557
REFERENCE   10 (residues 1 to 1050)
  AUTHORS   Hemmi H, Kaisho T, Takeuchi O, Sato S, Sanjo H, Hoshino K, Horiuchi
            T, Tomizawa H, Takeda K and Akira S.
  TITLE     Small anti-viral compounds activate immune cells via the TLR7
            MyD88-dependent signaling pathway
  JOURNAL   Nat Immunol 3 (2), 196-200 (2002)
   PUBMED   11812998
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL731735.14, AK036549.1, AJ812654.1 and BY543663.1.
            
            On Mar 19, 2014 this sequence version replaced XP_006528779.1.
            
            Transcript Variant: This variant (2) lacks an alternate exon in the
            5' region, compared to variant 1. Variants 1, 2, 3, and 4 encode
            the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219382.9711.1,
                                           SRR13861859.2517504.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1050
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 78.31 cM"
     Protein         1..1050
                     /product="toll-like receptor 7 isoform a precursor"
                     /note="Toll like receptor 7"
                     /calculated_mol_wt=118668
     sig_peptide     1..26
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
                     /calculated_mol_wt=3187
     Region          <32..>243
                     /region_name="PRK15370"
                     /note="type III secretion system effector E3 ubiquitin
                     transferase SlrP"
                     /db_xref="CDD:185268"
     Region          42..64
                     /region_name="LRR 1"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          48..69
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          65..87
                     /region_name="LRR 2"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Site            66
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Site            69
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Region          70..90
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          89..111
                     /region_name="LRR 3"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          91..128
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          126..149
                     /region_name="LRR 4"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          129..152
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          151..170
                     /region_name="LRR 5"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Site            167
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Region          171..195
                     /region_name="LRR 6"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          174..>786
                     /region_name="PLN00113"
                     /note="leucine-rich repeat receptor-like protein kinase;
                     Provisional"
                     /db_xref="CDD:215061"
     Region          174..205
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            190
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Region          203..226
                     /region_name="LRR 7"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          206..226
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            215
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Region          227..250
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          228..247
                     /region_name="LRR 8"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          248..273
                     /region_name="LRR 9"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          251..291
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          275..289
                     /region_name="LRR 10"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          290..312
                     /region_name="LRR 11"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          292..315
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          314..337
                     /region_name="LRR 12"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          316..341
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          339..364
                     /region_name="LRR 13"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          342..398
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          369..392
                     /region_name="LRR 14"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Site            387
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Region          396..419
                     /region_name="LRR 15"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          399..422
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          421..443
                     /region_name="LRR 16"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          493..516
                     /region_name="LRR 17"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          497..519
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          517..542
                     /region_name="LRR 18"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          520..544
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            524
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Site            535
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Region          543..565
                     /region_name="LRR 19"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          545..568
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          567..589
                     /region_name="LRR 20"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          569..598
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            591
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Region          596..619
                     /region_name="LRR 21"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          599..621
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          620..645
                     /region_name="LRR 22"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          622..652
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          650..673
                     /region_name="LRR 23"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          653..677
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          675..698
                     /region_name="LRR 24"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          678..701
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            680
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Region          699..722
                     /region_name="LRR 25"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          702..725
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            721
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Region          724..746
                     /region_name="LRR 26"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          747..770
                     /region_name="LRR 27"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          750..775
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          754..>838
                     /region_name="PCC"
                     /note="polycystin cation channel protein; TIGR00864"
                     /db_xref="CDD:188093"
     Region          773..796
                     /region_name="LRR 28"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Site            800
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Site            838..858
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          891..1036
                     /region_name="TIR"
                     /note="Toll - interleukin 1 - resistance; smart00255"
                     /db_xref="CDD:214587"
     CDS             1..1050
                     /gene="Tlr7"
                     /coded_by="NM_001290756.1:300..3452"
                     /note="isoform a precursor is encoded by transcript
                     variant 2"
                     /db_xref="CCDS:CCDS72469.1"
                     /db_xref="GeneID:170743"
                     /db_xref="MGI:MGI:2176882"
ORIGIN      
        1 mvfsmwtrkr qiliflnmll vsrvfgfrwf pktlpcevkv nipeahvivd ctdkhlteip
       61 egiptnttnl tltinhipsi spdsfrrlnh leeidlrcnc vpvllgskan vctkrlqirp
      121 gsfsglsdlk alyldgnqll eipqdlpssl hllsleanni fsitkenlte lvnietlylg
      181 qncyyrnpcn vsysiekdaf lvmrnlkvls lkdnnvtavp ttlppnllel ylynniikki
      241 qendfnnlne lqvldlsgnc prcynvpypc tpcennsplq ihdnafnslt elkvlrlhsn
      301 slqhvpptwf knmrnlqeld lsqnylarei eeakflhflp nlveldfsfn yelqvyhasi
      361 tlphslssle nlkilrvkgy vfkelknssl svlhklprle vldlgtnfik iadlnifkhf
      421 enlklidlsv nkispseesr evgfcpnaqt svdrhgpqvl ealhyfryde yarscrfknk
      481 eppsflplna dchiygqtld lsrnniffik psdfqhlsfl kclnlsgnti gqtlngselw
      541 plrelryldf snnrldllys tafeelqsle vldlssnshy fqaegithml nftkklrlld
      601 klmmndndis tsasrtmesd slrilefrgn hldvlwragd nryldffknl fnlevldisr
      661 nslnslppev fegmppnlkn lslaknglks ffwdrlqllk hleildlshn qltkvperla
      721 ncskslttli lkhnqirqlt kyfledalql ryldissnki qviqktsfpe nvlnnlemlv
      781 lhhnrflcnc davwfvwwvn htdvtipyla tdvtcvgpga hkgqsvisld lytceldltn
      841 lilfsvsiss vlflmvvmtt shlffwdmwy iyyfwkakik gyqhlqsmes cydafivydt
      901 knsavtewvl qelvakledp rekhfnlcle erdwlpgqpv lenlsqsiql skktvfvmtq
      961 kyaktesfkm afylshqrll dekvdviili flekplqksk flqlrkrlcr ssvlewpanp
     1021 qahpyfwqcl knalttdnhv aysqmfketv
//
LOCUS       NP_001313223            1104 aa            linear   ROD 09-OCT-2023
DEFINITION  A disintegrin and metalloproteinase with thrombospondin motifs 7
            isoform 3 [Mus musculus].
ACCESSION   NP_001313223 XP_006510826
VERSION     NP_001313223.1
DBSOURCE    REFSEQ: accession NM_001326294.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1104)
  AUTHORS   Sharifi MA, Wierer M, Dang TA, Milic J, Moggio A, Sachs N, von
            Scheidt M, Hinterdobler J, Muller P, Werner J, Stiller B,
            Aherrahrou Z, Erdmann J, Zaliani A, Graettinger M, Reinshagen J,
            Gul S, Gribbon P, Maegdefessel L, Bernhagen J, Sager HB, Mann M,
            Schunkert H and Kessler T.
  TITLE     ADAMTS-7 Modulates Atherosclerotic Plaque Formation by Degradation
            of TIMP-1
  JOURNAL   Circ Res 133 (8), 674-686 (2023)
   PUBMED   37675562
  REMARK    GeneRIF: ADAMTS-7 Modulates Atherosclerotic Plaque Formation by
            Degradation of TIMP-1.
REFERENCE   2  (residues 1 to 1104)
  AUTHORS   Gong Z, Huang J, Wang D, Yang S, Ma Z, Fu Y, Ma Q and Kong W.
  TITLE     ADAMTS-7 deficiency attenuates thoracic aortic aneurysm and
            dissection in mice
  JOURNAL   J Mol Med (Berl) 101 (3), 237-248 (2023)
   PUBMED   36662289
  REMARK    GeneRIF: ADAMTS-7 deficiency attenuates thoracic aortic aneurysm
            and dissection in mice.
REFERENCE   3  (residues 1 to 1104)
  AUTHORS   Ma Z, Mao C, Jia Y, Yu F, Xu P, Tan Y, Zou QH, Zhou XJ, Kong W and
            Fu Y.
  TITLE     ADAMTS7-Mediated Complement Factor H Degradation Potentiates
            Complement Activation to Contributing to Renal Injuries
  JOURNAL   J Am Soc Nephrol 34 (2), 291-308 (2023)
   PUBMED   36735376
  REMARK    GeneRIF: ADAMTS7-Mediated Complement Factor H Degradation
            Potentiates Complement Activation to Contributing to Renal
            Injuries.
REFERENCE   4  (residues 1 to 1104)
  AUTHORS   Jaiswal AK and Mishra A.
  TITLE     ADAMTS7 Attenuates House Dust Mite-Induced Airway Inflammation and
            Th2 Immune Responses
  JOURNAL   Lung 200 (3), 305-313 (2022)
   PUBMED   35503474
  REMARK    GeneRIF: ADAMTS7 Attenuates House Dust Mite-Induced Airway
            Inflammation and Th2 Immune Responses.
REFERENCE   5  (residues 1 to 1104)
  AUTHORS   Mizoguchi T, MacDonald BT, Bhandary B, Popp NR, Laprise D, Arduini
            A, Lai D, Zhu QM, Xing Y, Kaushik VK, Kathiresan S and Ellinor PT.
  TITLE     Coronary Disease Association With ADAMTS7 Is Due to Protease
            Activity
  JOURNAL   Circ Res 129 (4), 458-470 (2021)
   PUBMED   34176299
REFERENCE   6  (residues 1 to 1104)
  AUTHORS   Lai Y, Bai X, Zhao Y, Tian Q, Liu B, Lin EA, Chen Y, Lee B,
            Appleton CT, Beier F, Yu XP and Liu CJ.
  TITLE     ADAMTS-7 forms a positive feedback loop with TNF-alpha in the
            pathogenesis of osteoarthritis
  JOURNAL   Ann Rheum Dis 73 (8), 1575-1584 (2014)
   PUBMED   23928557
  REMARK    GeneRIF: ADAMTS-7 and TNF-alpha form a positive feedback loop in
            the regulation of cartilage degradation and osteoarthritis
            progression.
REFERENCE   7  (residues 1 to 1104)
  AUTHORS   Du J, Takeuchi H, Leonhard-Melief C, Shroyer KR, Dlugosz M,
            Haltiwanger RS and Holdener BC.
  TITLE     O-fucosylation of thrombospondin type 1 repeats restricts
            epithelial to mesenchymal transition (EMT) and maintains epiblast
            pluripotency during mouse gastrulation
  JOURNAL   Dev Biol 346 (1), 25-38 (2010)
   PUBMED   20637190
REFERENCE   8  (residues 1 to 1104)
  AUTHORS   Bai XH, Wang DW, Kong L, Zhang Y, Luan Y, Kobayashi T, Kronenberg
            HM, Yu XP and Liu CJ.
  TITLE     ADAMTS-7, a direct target of PTHrP, adversely regulates
            endochondral bone growth by associating with and inactivating GEP
            growth factor
  JOURNAL   Mol Cell Biol 29 (15), 4201-4219 (2009)
   PUBMED   19487464
  REMARK    GeneRIF: Findings demonstrate that ADAMTS-7, a direct target of
            PTHrP signaling, negatively regulates endochondral bone formation
            by associating with and inactivating GEP chondrogenic growth
            factor.
REFERENCE   9  (residues 1 to 1104)
  AUTHORS   Somerville RP, Longpre JM, Apel ED, Lewis RM, Wang LW, Sanes JR,
            Leduc R and Apte SS.
  TITLE     ADAMTS7B, the full-length product of the ADAMTS7 gene, is a
            chondroitin sulfate proteoglycan containing a mucin domain
  JOURNAL   J Biol Chem 279 (34), 35159-35175 (2004)
   PUBMED   15192113
  REMARK    GeneRIF: ADAMTS7B has a domain organization with a total of eight
            thrombospondin type 1 repeats in its ancillary domain. Of these,
            seven are arranged in two distinct clusters that are separated by a
            mucin domain
REFERENCE   10 (residues 1 to 1104)
  AUTHORS   Hurskainen TL, Hirohata S, Seldin MF and Apte SS.
  TITLE     ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of
            zinc metalloproteases. General features and genomic distribution of
            the ADAM-TS family
  JOURNAL   J Biol Chem 274 (36), 25555-25563 (1999)
   PUBMED   10464288
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY347798.1, BC076575.1 and
            BC058991.1.
            
            On May 13, 2016 this sequence version replaced XP_006510826.1.
            
            Summary: This gene encodes a member of 'a disintegrin and
            metalloproteinase with thrombospondin motifs' (ADAMTS) family of
            multi-domain matrix-associated metalloendopeptidases that have
            diverse roles in tissue morphogenesis and pathophysiological
            remodeling, in inflammation and in vascular biology. The encoded
            preproprotein undergoes proteolytic processing to generate an
            active, zinc-dependent enzyme that degrades cartilage oligomeric
            matrix protein. The deficiency of the encoded protein decreases
            atherosclerosis in genetically hyperlipidemic mice and in response
            to vascular injury. Alternative splicing results in multiple
            transcript variants encoding different isoforms, some of which may
            undergo similar processing. [provided by RefSeq, May 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC076575.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1104
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 47.46 cM"
     Protein         1..1104
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 7 isoform 3"
                     /EC_number="3.4.24.-"
                     /note="a disintegrin and metalloproteinase with
                     thrombospondin motifs 7; COMPase; a disintegrin-like and
                     metalloprotease (reprolysin type) with thrombospondin type
                     1 motif, 7; a disintegrin-like and metallopeptidase
                     (reprolysin type) with thrombospondin type 1 motif, 7"
                     /calculated_mol_wt=121056
     Region          73..171
                     /region_name="ADAM_CR_3"
                     /note="ADAM cysteine-rich domain; pfam19236"
                     /db_xref="CDD:437068"
     Region          173..282
                     /region_name="ADAM_spacer1"
                     /note="ADAM-TS Spacer 1; pfam05986"
                     /db_xref="CDD:428708"
     Region          297..351
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:408800"
     Region          355..411
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:408800"
     Region          <512..850
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          833..881
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:408800"
     Region          884..939
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:408800"
     Region          942..988
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:408800"
     Region          991..1046
                     /region_name="TSP1_ADAMTS"
                     /note="Thrombospondin type 1 domain; pfam19030"
                     /db_xref="CDD:408800"
     CDS             1..1104
                     /gene="Adamts7"
                     /gene_synonym="ADAM-TS7; ADAMTS7B"
                     /coded_by="NM_001326294.1:1655..4969"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="GeneID:108153"
                     /db_xref="MGI:MGI:1347346"
ORIGIN      
        1 mgltlptvrt wmmsathyga lwgppvtpsw mrlwmaravg rirpknrgky cvgerkrsql
       61 cnlpacppdr psfrhtqcsq fdgmlykgkl hkwvpvpndd npcelhcrps nssnteklrd
      121 avvdgtpcyq srisrdicln gicknvgcdf vidsgaeedr cgvcrgdgst cqtvsrtfke
      181 tegqgyvdig lipagareil ieevaeaanf lalrsedpdk yflnggwtiq wngdyrvagt
      241 tftyarkgnw enltspgpts epvwiqllfq eknpgvhyqy tiqrdshdqv rppefswhyg
      301 pwskctvtcg tgvqrqslyc merqagvvae eycntlnrpd erqrkcseep cpprwwagew
      361 qpcsrscgpe glsrravfci rsmgldeqra lelsacehlp rplaetpcnr hvicpstwgv
      421 gnwsqypmyi vdtgasgsgs sspelfnevd fipnqlaprp spasspkpvs isnaideeel
      481 dppgpvfvdd fyydynfinf hedlsygsfe ephpdlvdng gwtapphirp tespsdtpvp
      541 tagalgaeae diqgswspsp llseasyspp gleqtsinpl anflteedtp mgapelgfps
      601 lpwppasvdd mmtpvgpgnp dellvkedeq sppstpwsdr nklstdgnpl ghtspalpqs
      661 piptqpspps isptqaspsp dvvevstgwn aawdpvlead lkpghgelps tvevasppll
      721 pmatvpgiwg rdsplepgtp tfsspelssq hlktltmpgt llltvptdlr spgpsgqpqt
      781 pnlegtqspg llptparetq tnsskdpevq plqpsleedg dpadplparn aswqvgnwsq
      841 csttcglgai wrlvscssgn dedctlasrp qparhchlrp caawrtgnws kcsrncgggs
      901 strdvqcvdt rdlrplrpfh cqpgptkppn rqlcgtqpcl pwytsswrec seacgggeqq
      961 rlvtcpepgl ceeslrpnns rpcnthpctq wvvgpwgqcs apcgggvqrr lvrcvntqtg
     1021 laeedsdlcs heawpessrp catedcelve pprcerdrls fnfcetlrll grcqlptira
     1081 qccrscppls rgvpsrghqr varr
//
LOCUS       NP_031420                509 aa            linear   ROD 09-OCT-2023
DEFINITION  activin receptor type-1 precursor [Mus musculus].
ACCESSION   NP_031420
VERSION     NP_031420.2
DBSOURCE    REFSEQ: accession NM_007394.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 509)
  AUTHORS   Yang YS, Lin C, Ma H, Xie J, Kaplan FS, Gao G and Shim JH.
  TITLE     AAV-Mediated Targeting of the Activin A-ACVR1R206H Signaling in
            Fibrodysplasia Ossificans Progressiva
  JOURNAL   Biomolecules 13 (9), 1364 (2023)
   PUBMED   37759764
  REMARK    GeneRIF: AAV-Mediated Targeting of the Activin A-ACVR1[R206H]
            Signaling in Fibrodysplasia Ossificans Progressiva.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 509)
  AUTHORS   Yamaguchi H, Shen J, Little DR, Li M, Sozen S, Suzuki K, Mishina Y
            and Komatsu Y.
  TITLE     Enhanced BMP signaling through ALK2 attenuates keratinocyte
            differentiation
  JOURNAL   Biochem Biophys Res Commun 629, 101-105 (2022)
   PUBMED   36116371
  REMARK    GeneRIF: Enhanced BMP signaling through ALK2 attenuates
            keratinocyte differentiation.
REFERENCE   3  (residues 1 to 509)
  AUTHORS   Yamamoto M, Stoessel SJ, Yamamoto S and Goldhamer DJ.
  TITLE     Overexpression of Wild-Type ACVR1 in Fibrodysplasia Ossificans
            Progressiva Mice Rescues Perinatal Lethality and Inhibits
            Heterotopic Ossification
  JOURNAL   J Bone Miner Res 37 (11), 2077-2093 (2022)
   PUBMED   35637634
  REMARK    GeneRIF: Overexpression of Wild-Type ACVR1 in Fibrodysplasia
            Ossificans Progressiva Mice Rescues Perinatal Lethality and
            Inhibits Heterotopic Ossification.
REFERENCE   4  (residues 1 to 509)
  AUTHORS   Lees-Shepard JB, Stoessel SJ, Chandler JT, Bouchard K, Bento P,
            Apuzzo LN, Devarakonda PM, Hunter JW and Goldhamer DJ.
  TITLE     An anti-ACVR1 antibody exacerbates heterotopic ossification by
            fibro-adipogenic progenitors in fibrodysplasia ossificans
            progressiva mice
  JOURNAL   J Clin Invest 132 (12) (2022)
   PUBMED   35503416
REFERENCE   5  (residues 1 to 509)
  AUTHORS   Chen HY, Hu Y, Xu XB, Zhou YA, Li NS, He C, Xie C, Lu NH and Zhu Y.
  TITLE     Upregulation of oncogene Activin A receptor type I by Helicobacter
            pylori infection promotes gastric intestinal metaplasia via
            regulating CDX2
  JOURNAL   Helicobacter 26 (6), e12849 (2021)
   PUBMED   34490965
  REMARK    GeneRIF: Upregulation of oncogene Activin A receptor type I by
            Helicobacter pylori infection promotes gastric intestinal
            metaplasia via regulating CDX2.
REFERENCE   6  (residues 1 to 509)
  AUTHORS   Schmitt J, Mielke R and Schrewe H.
  TITLE     Genomic organization of a mouse type I activin receptor
  JOURNAL   Biochem Biophys Res Commun 213 (1), 211-217 (1995)
   PUBMED   7639738
REFERENCE   7  (residues 1 to 509)
  AUTHORS   Verschueren K, Dewulf N, Goumans MJ, Lonnoy O, Feijen A, Grimsby S,
            Vandi Spiegle K, ten Dijke P, Moren A, Vanscheeuwijck P, Heldin CH,
            Miyazono K, Mummery C, Van Den Eijnden-Van Raaij J and Huylebroeck
            D.
  TITLE     Expression of type I and type IB receptors for activin in
            midgestation mouse embryos suggests distinct functions in
            organogenesis
  JOURNAL   Mech Dev 52 (1), 109-123 (1995)
   PUBMED   7577669
REFERENCE   8  (residues 1 to 509)
  AUTHORS   Roelen BA, Lin HY, Knezevic V, Freund E and Mummery CL.
  TITLE     Expression of TGF-beta s and their receptors during implantation
            and organogenesis of the mouse embryo
  JOURNAL   Dev Biol 166 (2), 716-728 (1994)
   PUBMED   7813789
REFERENCE   9  (residues 1 to 509)
  AUTHORS   Nakamura T, Sugino K, Kurosawa N, Sawai M, Takio K, Eto Y, Iwashita
            S, Muramatsu M, Titani K and Sugino H.
  TITLE     Isolation and characterization of activin receptor from mouse
            embryonal carcinoma cells. Identification of its
            serine/threonine/tyrosine protein kinase activity
  JOURNAL   J Biol Chem 267 (26), 18924-18928 (1992)
   PUBMED   1326537
REFERENCE   10 (residues 1 to 509)
  AUTHORS   Mathews LS and Vale WW.
  TITLE     Expression cloning of an activin receptor, a predicted
            transmembrane serine kinase
  JOURNAL   Cell 65 (6), 973-982 (1991)
   PUBMED   1646080
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK150014.1, BC058718.1 and BQ030975.1.
            
            On Dec 20, 2003 this sequence version replaced NP_031420.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. All five variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK150014.1, AK150075.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 33.05 cM"
     Protein         1..509
                     /product="activin receptor type-1 precursor"
                     /EC_number="2.7.11.30"
                     /note="activin receptor type-1; TSR-I; TSK-7L; activin
                     receptor type I; TGF-B superfamily receptor type I;
                     serine/threonine-protein kinase receptor R1"
                     /calculated_mol_wt=55077
     sig_peptide     1..20
                     /note="/evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (P37172.2)"
                     /calculated_mol_wt=2167
     mat_peptide     21..509
                     /product="Activin receptor type-1. /id=PRO_0000024395"
                     /note="propagated from UniProtKB/Swiss-Prot (P37172.2)"
                     /calculated_mol_wt=55077
     Region          33..103
                     /region_name="Activin_recp"
                     /note="Activin types I and II receptor domain; pfam01064"
                     /db_xref="CDD:426025"
     Site            102
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P37172.2)"
     Site            124..146
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P37172.2)"
     Region          179..206
                     /region_name="TGF_beta_GS"
                     /note="Transforming growth factor beta type I GS-motif;
                     pfam08515"
                     /db_xref="CDD:430045"
     Region          202..499
                     /region_name="STKc_ACVR1_ALK1"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     Activin Type I Receptor and Activin receptor-Like Kinase
                     1; cd14142"
                     /db_xref="CDD:271044"
     Site            order(202..203,206..207,245..246,249..250,253..254,268,
                     270)
                     /site_type="other"
                     /note="FKBP12 binding site [polypeptide binding]"
                     /db_xref="CDD:271044"
     Site            order(214..218,222,233,235,263,283..286,290,292,336,338,
                     340..341,343,354,357,377..380)
                     /site_type="active"
                     /db_xref="CDD:271044"
     Site            order(214..220,222,233,235,283..284,286,290,340..341,343,
                     354)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271044"
     Site            order(218,290,292,336,338,340,357,377..380)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:271044"
     Site            353..380
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:271044"
     Site            501
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04771; propagated from
                     UniProtKB/Swiss-Prot (P37172.2)"
     CDS             1..509
                     /gene="Acvr1"
                     /gene_synonym="ActR-I; ActRIA; Acvr; Acvr1a; Acvrlk2;
                     Alk-2; ALK2; Alk8; D330013D15Rik; SKR1; Tsk7L"
                     /coded_by="NM_007394.3:423..1952"
                     /db_xref="CCDS:CCDS16050.1"
                     /db_xref="GeneID:11477"
                     /db_xref="MGI:MGI:87911"
ORIGIN      
        1 mvdgvmilpv lmmmafpsps vedekpkvnq klymcvcegl scgnedhceg qqcfsslsin
       61 dgfhvyqkgc fqvyeqgkmt cktppspgqa veccqgdwcn rnitaqlptk gksfpgtqnf
      121 hlevgliils vvfavcllac ilgvalrkfk rrnqerlnpr dveygtiegl ittnvgdstl
      181 aelldhscts gsgsglpflv qrtvarqitl lecvgkgryg evwrgswqge nvavkifssr
      241 dekswfrete lyntvmlrhe nilgfiasdm tsrhsstqlw lithyhemgs lydylqlttl
      301 dtvsclrivl siasglahlh ieifgtqgks aiahrdlksk nilvkkngqc ciadlglavm
      361 hsqstnqldv gnnprvgtkr ymapevldet iqvdcfdsyk rvdiwafglv lwevarrmvs
      421 ngivedykpp fydvvpndps fedmrkvvcv dqqrpnipnr wfsdptltsl aklmkecwyq
      481 npsarltalr ikktltkidn sldklktdc
//
LOCUS       NP_001167021             351 aa            linear   ROD 09-OCT-2023
DEFINITION  C5a anaphylatoxin chemotactic receptor 1 [Mus musculus].
ACCESSION   NP_001167021
VERSION     NP_001167021.1
DBSOURCE    REFSEQ: accession NM_001173550.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 351)
  AUTHORS   Petrisko TJ, Gargus M, Chu SH, Selvan P, Whiteson KL and Tenner AJ.
  TITLE     Influence of complement protein C1q or complement receptor C5aR1 on
            gut microbiota composition in wildtype and Alzheimer's mouse models
  JOURNAL   J Neuroinflammation 20 (1), 211 (2023)
   PUBMED   37726739
  REMARK    GeneRIF: Influence of complement protein C1q or complement receptor
            C5aR1 on gut microbiota composition in wildtype and Alzheimer's
            mouse models.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 351)
  AUTHORS   Wiese AV, Duhn J, Korkmaz RU, Quell KM, Osman I, Ender F, Schroder
            T, Lewkowich I, Hogan S, Huber-Lang M, Gumprecht F, Konig P, Kohl J
            and Laumonnier Y.
  TITLE     C5aR1 activation in mice controls inflammatory eosinophil
            recruitment and functions in allergic asthma
  JOURNAL   Allergy 78 (7), 1893-1908 (2023)
   PUBMED   36757006
  REMARK    GeneRIF: C5aR1 activation in mice controls inflammatory eosinophil
            recruitment and functions in allergic asthma.
REFERENCE   3  (residues 1 to 351)
  AUTHORS   Silva BM, Gomes GF, Veras FP, Cambier S, Silva GV, Quadros AU,
            Caetite DB, Nascimento DC, Silva CM, Silva JC, Damasceno S,
            Schneider AH, Beretta F, Batah SS, Castro IM, Paiva IM, Rodrigues
            T, Salina A, Martins R, Cebinelli GC, Bibo NL, Jorge DM, Nakaya HI,
            Zamboni DS, Leiria LO, Fabro AT, Alves-Filho JC, Arruda E,
            Louzada-Junior P, Oliveira RD, Cunha LD, Van Mol P, Vanderbeke L,
            Feys S, Wauters E, Brandolini L, Aramini A, Cunha FQ, Kohl J,
            Allegretti M, Lambrechts D, Wauters J, Proost P and Cunha TM.
  TITLE     C5aR1 signaling triggers lung immunopathology in COVID-19 through
            neutrophil extracellular traps
  JOURNAL   J Clin Invest 133 (12), e163105 (2023)
   PUBMED   37104043
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 351)
  AUTHORS   Ratajczak MZ, Adamiak M, Abdelbaset-Ismail A, Bujko K, Thapa A,
            Chumak V, Franczak S, Brzezniakiewicz-Janus K, Ratajczak J and
            Kucia M.
  TITLE     Intracellular complement (complosome) is expressed in hematopoietic
            stem/progenitor cells (HSPCs) and regulates cell trafficking,
            metabolism and proliferation in an intracrine Nlrp3
            inflammasome-dependent manner
  JOURNAL   Leukemia 37 (6), 1401-1405 (2023)
   PUBMED   37055506
REFERENCE   5  (residues 1 to 351)
  AUTHORS   Kong LR, Chen XH, Sun Q, Zhang KY, Xu L, Ding L, Zhou YP, Zhang ZB,
            Lin JR and Gao PJ.
  TITLE     Loss of C3a and C5a receptors promotes adipocyte browning and
            attenuates diet-induced obesity via activating inosine/A2aR pathway
  JOURNAL   Cell Rep 42 (2), 112078 (2023)
   PUBMED   36735535
  REMARK    GeneRIF: Loss of C3a and C5a receptors promotes adipocyte browning
            and attenuates diet-induced obesity via activating inosine/A2aR
            pathway.
REFERENCE   6  (residues 1 to 351)
  AUTHORS   Clynes R, Maizes JS, Guinamard R, Ono M, Takai T and Ravetch JV.
  TITLE     Modulation of immune complex-induced inflammation in vivo by the
            coordinate expression of activation and inhibitory Fc receptors
  JOURNAL   J Exp Med 189 (1), 179-185 (1999)
   PUBMED   9874574
REFERENCE   7  (residues 1 to 351)
  AUTHORS   Hopken UE, Lu B, Gerard NP and Gerard C.
  TITLE     Impaired inflammatory responses in the reverse arthus reaction
            through genetic deletion of the C5a receptor
  JOURNAL   J Exp Med 186 (5), 749-756 (1997)
   PUBMED   9271590
REFERENCE   8  (residues 1 to 351)
  AUTHORS   Bozic CR, Lu B, Hopken UE, Gerard C and Gerard NP.
  TITLE     Neurogenic amplification of immune complex inflammation
  JOURNAL   Science 273 (5282), 1722-1725 (1996)
   PUBMED   8781237
REFERENCE   9  (residues 1 to 351)
  AUTHORS   Hopken UE, Lu B, Gerard NP and Gerard C.
  TITLE     The C5a chemoattractant receptor mediates mucosal defence to
            infection
  JOURNAL   Nature 383 (6595), 86-89 (1996)
   PUBMED   8779720
REFERENCE   10 (residues 1 to 351)
  AUTHORS   Gerard C, Bao L, Orozco O, Pearson M, Kunz D and Gerard NP.
  TITLE     Structural diversity in the extracellular faces of peptidergic
            G-protein-coupled receptors. Molecular cloning of the mouse C5a
            anaphylatoxin receptor
  JOURNAL   J Immunol 149 (8), 2600-2606 (1992)
   PUBMED   1401897
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156630.6.
            
            Transcript Variant: This variant (2) has an alternate 5' UTR, as
            compared to variant 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK158027.1, BC125641.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..351
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 8.77 cM"
     Protein         1..351
                     /product="C5a anaphylatoxin chemotactic receptor 1"
                     /note="C5a anaphylatoxin receptor; C5a-R; complement
                     component 5, receptor 1; C5a ligand"
                     /calculated_mol_wt=38892
     Site            6
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P30993.2)"
     Site            13
                     /site_type="sulfatation"
                     /note="Sulfotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P21730; propagated from
                     UniProtKB/Swiss-Prot (P30993.2)"
     Site            16
                     /site_type="sulfatation"
                     /note="Sulfotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P21730; propagated from
                     UniProtKB/Swiss-Prot (P30993.2)"
     Region          38..312
                     /region_name="7tm_GPCRs"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; cl28897"
                     /db_xref="CDD:452889"
     Site            38..64
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P30993.2)"
     Region          40..64
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:410628"
     Site            70..93
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P30993.2)"
     Region          72..93
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:410628"
     Region          110..132
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:410628"
     Site            111..132
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P30993.2)"
     Site            154..174
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P30993.2)"
     Region          155..171
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:410628"
     Region          201..224
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:410628"
     Site            202..227
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P30993.2)"
     Region          242..264
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:410628"
     Site            244..266
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P30993.2)"
     Region          280..305
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:410628"
     Site            284..304
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P30993.2)"
     Site            315
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P21730; propagated from
                     UniProtKB/Swiss-Prot (P30993.2)"
     Site            318
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P21730; propagated from
                     UniProtKB/Swiss-Prot (P30993.2)"
     Site            325
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19144319,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P30993.2)"
     Site            328
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P21730; propagated from
                     UniProtKB/Swiss-Prot (P30993.2)"
     Region          329..351
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P30993.2)"
     Site            333
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19144319; propagated from
                     UniProtKB/Swiss-Prot (P30993.2)"
     Site            339
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P21730; propagated from
                     UniProtKB/Swiss-Prot (P30993.2)"
     CDS             1..351
                     /gene="C5ar1"
                     /gene_synonym="C5aR; C5r1; Cd88; D7Msu1"
                     /coded_by="NM_001173550.1:192..1247"
                     /db_xref="CCDS:CCDS20846.1"
                     /db_xref="GeneID:12273"
                     /db_xref="MGI:MGI:88232"
ORIGIN      
        1 mdpidnssfe inydhygtmd pnipadgihl pkrqpgdvaa liiysvvflv gvpgnalvvw
       61 vtafearrav naiwflnlav adllsclalp vlfttvlnhn ywyfdataci vlpslillnm
      121 yasilllati sadrfllvfk piwcqkvrgt glawmacgva wvlallltip sfvyreaykd
      181 fysehtvcgi nygggsfpke kavailrlmv gfvlplltln icytflllrt wsrkatrstk
      241 tlkvvmavvi cffifwlpyq vtgvmiawlp pssptlkrve klnslcvsla yinccvnpii
      301 yvmagqgfhg rllrslpsii rnalsedsvg rdsktftpst tdtstrksqa v
//
LOCUS       NP_001396720              73 aa            linear   ROD 09-OCT-2023
DEFINITION  SWI/SNF-related matrix-associated actin-dependent regulator of
            chromatin subfamily A containing DEAD/H box 1 isoform 3 [Mus
            musculus].
ACCESSION   NP_001396720
VERSION     NP_001396720.1
DBSOURCE    REFSEQ: accession NM_001409791.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 73)
  AUTHORS   Sachs P, Bergmaier P, Treutwein K and Mermoud JE.
  TITLE     The Conserved Chromatin Remodeler SMARCAD1 Interacts with TFIIIC
            and Architectural Proteins in Human and Mouse
  JOURNAL   Genes (Basel) 14 (9), 1793 (2023)
   PUBMED   37761933
  REMARK    GeneRIF: The Conserved Chromatin Remodeler SMARCAD1 Interacts with
            TFIIIC and Architectural Proteins in Human and Mouse.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 73)
  AUTHORS   Bedogni F and Hevner RF.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 73)
  AUTHORS   Niu Q, Wang W, Wei Z, Byeon B, Das AB, Chen BS and Wu WH.
  TITLE     Role of the ATP-dependent chromatin remodeling enzyme
            Fun30/Smarcad1 in the regulation of mRNA splicing
  JOURNAL   Biochem Biophys Res Commun 526 (2), 453-458 (2020)
   PUBMED   32234239
  REMARK    GeneRIF: Role of the ATP-dependent chromatin remodeling enzyme
            Fun30/Smarcad1 in the regulation of mRNA splicing.
REFERENCE   4  (residues 1 to 73)
  AUTHORS   Kazakevych J, Denizot J, Liebert A, Portovedo M, Mosavie M, Jain P,
            Stellato C, Fraser C, Correa RO, Celestine M, Mattiuz R, Okkenhaug
            H, Miller JR, Vinolo MAR, Veldhoen M and Varga-Weisz P.
  TITLE     Smarcad1 mediates microbiota-induced inflammation in mouse and
            coordinates gene expression in the intestinal epithelium
  JOURNAL   Genome Biol 21 (1), 64 (2020)
   PUBMED   32160911
  REMARK    GeneRIF: Smarcad1 mediates microbiota-induced inflammation in mouse
            and coordinates gene expression in the intestinal epithelium.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 73)
  AUTHORS   Sachs P, Ding D, Bergmaier P, Lamp B, Schlagheck C, Finkernagel F,
            Nist A, Stiewe T and Mermoud JE.
  TITLE     SMARCAD1 ATPase activity is required to silence endogenous
            retroviruses in embryonic stem cells
  JOURNAL   Nat Commun 10 (1), 1335 (2019)
   PUBMED   30902974
  REMARK    GeneRIF: These findings uncover a role for the enzymatic activity
            of SMARCAD1 in cooperating with KAP1 to silence Endogenous
            retroviruses.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 73)
  AUTHORS   Ben-Arie N, McCall AE, Berkman S, Eichele G, Bellen HJ and Zoghbi
            HY.
  TITLE     Evolutionary conservation of sequence and expression of the bHLH
            protein Atonal suggests a conserved role in neurogenesis
  JOURNAL   Hum Mol Genet 5 (9), 1207-1216 (1996)
   PUBMED   8872459
REFERENCE   7  (residues 1 to 73)
  AUTHORS   Villeneuve L, Jiang X, Turmel C, Kozak CA and Jolicoeur P.
  TITLE     Long-range mapping of Mis-2, a common provirus integration site
            identified in murine leukemia virus-induced thymomas and located
            160 kilobase pairs downstream of Myb
  JOURNAL   J Virol 67 (10), 5733-5739 (1993)
   PUBMED   8371338
REFERENCE   8  (residues 1 to 73)
  AUTHORS   Schoor M, Schuster-Gossler K and Gossler A.
  TITLE     The Etl-1 gene encodes a nuclear protein differentially expressed
            during early mouse development
  JOURNAL   Dev Dyn 197 (3), 227-237 (1993)
   PUBMED   8219362
REFERENCE   9  (residues 1 to 73)
  AUTHORS   Soininen R, Schoor M, Henseling U, Tepe C, Kisters-Woike B, Rossant
            J and Gossler A.
  TITLE     The mouse Enhancer trap locus 1 (Etl-1): a novel mammalian gene
            related to Drosophila and yeast transcriptional regulator genes
  JOURNAL   Mech Dev 39 (1-2), 111-123 (1992)
   PUBMED   1489724
REFERENCE   10 (residues 1 to 73)
  AUTHORS   O'Kane CJ and Gehring WJ.
  TITLE     Detection in situ of genomic regulatory elements in Drosophila
  JOURNAL   Proc Natl Acad Sci U S A 84 (24), 9123-9127 (1987)
   PUBMED   2827169
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC138622.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14777531.545913.1,
                                           SRR17253011.1303612.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..73
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 30.11 cM"
     Protein         1..73
                     /product="SWI/SNF-related matrix-associated
                     actin-dependent regulator of chromatin subfamily A
                     containing DEAD/H box 1 isoform 3"
                     /EC_number="3.6.4.12"
                     /note="enhancer trap locus homolog 1; ATP-dependent
                     helicase SMARCAD1; enhancer trap locus 1"
                     /calculated_mol_wt=7806
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:Q9H4L7; propagated from
                     UniProtKB/Swiss-Prot (Q04692.2)"
     Site            54
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9H4L7; propagated from
                     UniProtKB/Swiss-Prot (Q04692.2)"
     Site            57
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H4L7; propagated from
                     UniProtKB/Swiss-Prot (Q04692.2)"
     CDS             1..73
                     /gene="Smarcad1"
                     /gene_synonym="D6Pas1; etl-1; Etl1; mKIAA1122"
                     /coded_by="NM_001409791.1:335..556"
                     /note="isoform 3 is encoded by transcript variant 7"
                     /db_xref="GeneID:13990"
                     /db_xref="MGI:MGI:95453"
ORIGIN      
        1 mnlfnldrfr fekrskieea peaapqpsqa rpsspislsa eeenaegegs rantpdsdvt
       61 ektgsdfval alv
//
LOCUS       NP_001300848             837 aa            linear   ROD 09-OCT-2023
DEFINITION  hypoxia-inducible factor 1-alpha isoform 1 [Mus musculus].
ACCESSION   NP_001300848 XP_006515540
VERSION     NP_001300848.1
DBSOURCE    REFSEQ: accession NM_001313919.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 837)
  AUTHORS   Xu R, Shen S, Wang D, Ye J, Song S, Wang Z and Yue Z.
  TITLE     The role of HIF-1alpha-mediated autophagy in ionizing
            radiation-induced testicular injury
  JOURNAL   J Mol Histol 54 (5), 439-451 (2023)
   PUBMED   37728670
  REMARK    GeneRIF: The role of HIF-1alpha-mediated autophagy in ionizing
            radiation-induced testicular injury.
REFERENCE   2  (residues 1 to 837)
  AUTHORS   Yang Z, Su W, Wei X, Qu S, Zhao D, Zhou J, Wang Y, Guan Q, Qin C,
            Xiang J, Zen K and Yao B.
  TITLE     HIF-1alpha drives resistance to ferroptosis in solid tumors by
            promoting lactate production and activating SLC1A1
  JOURNAL   Cell Rep 42 (8), 112945 (2023)
   PUBMED   37542723
  REMARK    GeneRIF: HIF-1alpha drives resistance to ferroptosis in solid
            tumors by promoting lactate production and activating SLC1A1.
REFERENCE   3  (residues 1 to 837)
  AUTHORS   Dery KJ, Kojima H, Kageyama S, Kadono K, Hirao H, Cheng B, Zhai Y,
            Farmer DG, Kaldas FM, Yuan X, Eltzschig HK and Kupiec-Weglinski JW.
  TITLE     Alternative splicing of CEACAM1 by hypoxia-inducible factor-1alpha
            enhances tolerance to hepatic ischemia in mice and humans
  JOURNAL   Sci Transl Med 15 (707), eadf2059 (2023)
   PUBMED   37531413
  REMARK    GeneRIF: Alternative splicing of CEACAM1 by hypoxia-inducible
            factor-1alpha enhances tolerance to hepatic ischemia in mice and
            humans.
REFERENCE   4  (residues 1 to 837)
  AUTHORS   Guo Z, Yu X, Zhao S, Zhong X, Huang D, Feng R, Li P, Fang Z, Hu Y,
            Zhang Z, Abdurahman M, Huang L, Zhao Y, Wang X, Ge J and Li H.
  TITLE     SIRT6 deficiency in endothelial cells exacerbates oxidative stress
            by enhancing HIF1alpha accumulation and H3K9 acetylation at the
            Ero1alpha promoter
  JOURNAL   Clin Transl Med 13 (8), e1377 (2023)
   PUBMED   37598403
  REMARK    GeneRIF: SIRT6 deficiency in endothelial cells exacerbates
            oxidative stress by enhancing HIF1alpha accumulation and H3K9
            acetylation at the Ero1alpha promoter.
REFERENCE   5  (residues 1 to 837)
  AUTHORS   Zhang G, Liu B, Yang Y, Xie S, Chen L, Luo H, Zhong J, Wei Y, Guo
            F, Gan J, Zhu F, Xu L, Li Q, Shen Y, Zhang H, Liu Y, Li R, Deng H
            and Yang H.
  TITLE     Mitochondrial UQCC3 controls embryonic and tumor angiogenesis by
            regulating VEGF expression
  JOURNAL   iScience 26 (8), 107370 (2023)
   PUBMED   37539028
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 837)
  AUTHORS   Li H, Ko HP and Whitlock JP.
  TITLE     Induction of phosphoglycerate kinase 1 gene expression by hypoxia.
            Roles of Arnt and HIF1alpha
  JOURNAL   J Biol Chem 271 (35), 21262-21267 (1996)
   PUBMED   8702901
REFERENCE   7  (residues 1 to 837)
  AUTHORS   Wood SM, Gleadle JM, Pugh CW, Hankinson O and Ratcliffe PJ.
  TITLE     The role of the aryl hydrocarbon receptor nuclear translocator
            (ARNT) in hypoxic induction of gene expression. Studies in
            ARNT-deficient cells
  JOURNAL   J Biol Chem 271 (25), 15117-15123 (1996)
   PUBMED   8662957
REFERENCE   8  (residues 1 to 837)
  AUTHORS   Semenza GL, Rue EA, Iyer NV, Pang MG and Kearns WG.
  TITLE     Assignment of the hypoxia-inducible factor 1alpha gene to a region
            of conserved synteny on mouse chromosome 12 and human chromosome
            14q
  JOURNAL   Genomics 34 (3), 437-439 (1996)
   PUBMED   8786149
REFERENCE   9  (residues 1 to 837)
  AUTHORS   Wenger RH, Rolfs A, Marti HH, Guenet JL and Gassmann M.
  TITLE     Nucleotide sequence, chromosomal assignment and mRNA expression of
            mouse hypoxia-inducible factor-1 alpha
  JOURNAL   Biochem Biophys Res Commun 223 (1), 54-59 (1996)
   PUBMED   8660378
REFERENCE   10 (residues 1 to 837)
  AUTHORS   Obara N and Takeda M.
  TITLE     Expression of neural cell adhesion molecule (NCAM) during the first
            molar development in the mouse
  JOURNAL   Anat Embryol (Berl) 187 (3), 209-219 (1993)
   PUBMED   8470821
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124712.5.
            
            On Sep 11, 2015 this sequence version replaced XP_006515540.1.
            
            Summary: This gene encodes the alpha subunit which, along with the
            beta subunit, forms a heterodimeric transcription factor that
            regulates the cellular and developmental response to reduced oxygen
            tension. The transcription factor has been shown to regulate genes
            involved in several biological processes, including erythropoiesis
            and angiogenesis which aid in increased delivery of oxygen to
            hypoxic regions. The transcription factor also plays a role in the
            induction of genes involved in cell proliferation and survival,
            energy metabolism, apoptosis, and glucose and iron metabolism.
            Alternative splicing results in multiple transcript variants
            encoding different isoforms. [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK034087.1, SRR9219383.41849.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..837
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 31.99 cM"
     Protein         1..837
                     /product="hypoxia-inducible factor 1-alpha isoform 1"
                     /note="hypoxia-inducible factor 1-alpha; ARNT-interacting
                     protein"
                     /calculated_mol_wt=93528
     Region          14..84
                     /region_name="bHLH-PAS_HIF1a_PASD8"
                     /note="basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS)
                     domain found in hypoxia-inducible factor 1-alpha (HIF1a)
                     and similar proteins; cd19727"
                     /db_xref="CDD:381570"
     Site            order(19..20,22..24,27..28,30..31,56..57)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381570"
     Region          22..31
                     /region_name="DNA-binding.
                     /evidence=ECO:0000269|PubMed:26245371"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Site            order(33..34,36..37,40..41,44..45,56..58,61..62,65,68..69,
                     72)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:381570"
     Region          94..149
                     /region_name="PAS"
                     /note="PAS domain; smart00091"
                     /db_xref="CDD:214512"
     Region          171..192
                     /region_name="Required for heterodimer formation with
                     ARNT. /evidence=ECO:0000269|PubMed:26245371"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Site            248
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK1.
                     /evidence=ECO:0000250|UniProtKB:Q16665; propagated from
                     UniProtKB/Swiss-Prot (Q61221.3)"
     Region          255..340
                     /region_name="PAS_3"
                     /note="PAS fold; pfam08447"
                     /db_xref="CDD:430001"
     Site            order(256,260,266,279..282,308,313)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:238075"
     Site            order(276,280,288,291..292,320,322)
                     /site_type="other"
                     /note="heme pocket [chemical binding]"
                     /db_xref="CDD:238075"
     Region          381..418
                     /region_name="N-terminal VHL recognition site"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Region          402..614
                     /region_name="ODD"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Site            403
                     /site_type="hydroxylation"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:Q16665; propagated from
                     UniProtKB/Swiss-Prot (Q61221.3)"
     Region          493..512
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Region          545..589
                     /region_name="NTAD"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Site            546
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:Q16665; propagated from
                     UniProtKB/Swiss-Prot (Q61221.3)"
     Region          565..594
                     /region_name="HIF-1"
                     /note="Hypoxia-inducible factor-1; pfam11413"
                     /db_xref="CDD:431874"
     Site            565
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by GSK3-beta.
                     /evidence=ECO:0000250|UniProtKB:Q16665; propagated from
                     UniProtKB/Swiss-Prot (Q61221.3)"
     Site            569
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by GSK3-beta.
                     /evidence=ECO:0000250|UniProtKB:Q16665; propagated from
                     UniProtKB/Swiss-Prot (Q61221.3)"
     Region          570..586
                     /region_name="C-terminal VHL recognition site"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Site            578
                     /site_type="hydroxylation"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:Q16665; propagated from
                     UniProtKB/Swiss-Prot (Q61221.3)"
     Region          590..796
                     /region_name="ID"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Site            590
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PLK3.
                     /evidence=ECO:0000250|UniProtKB:Q16665; propagated from
                     UniProtKB/Swiss-Prot (Q61221.3)"
     Region          594..685
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Site            603
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by GSK3-beta.
                     /evidence=ECO:0000250|UniProtKB:Q16665; propagated from
                     UniProtKB/Swiss-Prot (Q61221.3)"
     Site            669
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PLK3.
                     /evidence=ECO:0000250|UniProtKB:Q16665; propagated from
                     UniProtKB/Swiss-Prot (Q61221.3)"
     Region          708..735
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Site            720
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q16665; propagated from
                     UniProtKB/Swiss-Prot (Q61221.3)"
     Region          729..732
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Region          797..837
                     /region_name="CTAD"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Region          800..836
                     /region_name="HIF-1a_CTAD"
                     /note="HIF-1 alpha C terminal transactivation domain;
                     pfam08778"
                     /db_xref="CDD:430212"
     Site            814
                     /site_type="hydroxylation"
                     /note="(3S)-3-hydroxyasparagine.
                     /evidence=ECO:0000250|UniProtKB:Q16665; propagated from
                     UniProtKB/Swiss-Prot (Q61221.3)"
     CDS             1..837
                     /gene="Hif1a"
                     /gene_synonym="bHLHe78; HIF-1-alpha; HIF1-alpha;
                     HIF1alpha; MOP1"
                     /coded_by="NM_001313919.2:290..2803"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:15251"
                     /db_xref="MGI:MGI:106918"
ORIGIN      
        1 megaggenek knrmsserrk eksrdaarsr rskesevfye lahqlplphn vsshldkasv
       61 mrltisylrv rklldaggld sedemkaqmd cfylkaldgf vmvltddgdm vyisdnvnky
      121 mgltqfeltg hsvfdfthpc dheemremlt hrngpvrkgk elntqrsffl rmkctltsrg
      181 rtmniksatw kvlhctghih vydtnsnqpq cgykkppmtc lvlicepiph psnieiplds
      241 ktflsrhsld mkfsycderi telmgyepee llgrsiyeyy haldsdhltk thhdmftkgq
      301 vttgqyrmla krggyvwvet qatviyntkn sqpqcivcvn yvvsgiiqhd lifslqqtes
      361 vlkpvessdm kmtqlftkve sedtsclfdk lkkepdaltl lapaagdtii sldfgsddte
      421 tedqqledvp lyndvmfpss neklninlam splpssetpk plrssadpal nqevalkles
      481 speslglsft mpqiqdqpas psdgstrqss perllqenvn tpnfsqpnsp seycfdvdsd
      541 mvnvfklelv eklfaedtea knpfstqdtd ldlemlapyi pmdddfqlrs fdqlsplesn
      601 spsppsmstv tgfqqtqlqk ptitatattt attdesktet kdnkedikil iaspsstqvp
      661 qetttakasa ysgthsrtas pdragkrvie qtdkahprsl nlsatlnqrn tvpeeelnpk
      721 tiasqnaqrk rkmehdgslf qaagigtllq qpgdcaptms lswkrvkgfi sseqngteqk
      781 tiilipsdla crllgqsmde sglpqltsyd cevnapiqgs rnllqgeell raldqvn
//
LOCUS       NP_001343356             115 aa            linear   ROD 09-OCT-2023
DEFINITION  pancreatic progenitor cell differentiation and proliferation factor
            isoform a [Mus musculus].
ACCESSION   NP_001343356 XP_006500766
VERSION     NP_001343356.1
DBSOURCE    REFSEQ: accession NM_001356427.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 115)
  AUTHORS   Wang YK, Ma N, Xu S, Huang JY, Ni QZ, Cao HJ, Zheng QW, Zhu B, Xia
            J, Zhang FK, Ding XF, Qiu XS, Chen TW, Wang K, Chen W, Li ZG, Cheng
            SQ, Xie D and Li JJ.
  TITLE     PPDPF suppresses the development of hepatocellular carcinoma
            through TRIM21-mediated ubiquitination of RIPK1
  JOURNAL   Cell Rep 42 (4), 112340 (2023)
   PUBMED   37027301
  REMARK    GeneRIF: PPDPF suppresses the development of hepatocellular
            carcinoma through TRIM21-mediated ubiquitination of RIPK1.
REFERENCE   2  (residues 1 to 115)
  AUTHORS   Ni QZ, Zhu B, Ji Y, Zheng QW, Liang X, Ma N, Jiang H, Zhang FK,
            Shang YR, Wang YK, Xu S, Zhang EB, Yuan YM, Chen TW, Yin FF, Cao
            HJ, Huang JY, Xia J, Ding XF, Qiu XS, Ding K, Song C, Zhou WT, Wu
            M, Wang K, Lui R, Lin Q, Chen W, Li ZG, Cheng SQ, Wang XF, Xie D
            and Li JJ.
  TITLE     PPDPF Promotes the Development of Mutant KRAS-Driven Pancreatic
            Ductal Adenocarcinoma by Regulating the GEF Activity of SOS1
  JOURNAL   Adv Sci (Weinh) 10 (2), e2202448 (2023)
   PUBMED   36453576
  REMARK    GeneRIF: PPDPF Promotes the Development of Mutant KRAS-Driven
            Pancreatic Ductal Adenocarcinoma by Regulating the GEF Activity of
            SOS1.
REFERENCE   3  (residues 1 to 115)
  AUTHORS   Zheng QW, Ni QZ, Zhu B, Liang X, Ma N, Wang YK, Xu S, Cao HJ, Xia
            J, Zhang FK, Zhang EB, Qiu XS, Ding XF, Qiu L, Zhang XL, Dong ZH,
            Li ZG, Zhang XL, Xie D and Li JJ.
  TITLE     PPDPF promotes lung adenocarcinoma progression via inhibiting
            apoptosis and NK cell-mediated cytotoxicity through STAT3
  JOURNAL   Oncogene 41 (36), 4244-4256 (2022)
   PUBMED   35906391
  REMARK    Erratum:[Oncogene. 2023 Aug;42(35):2655-2656. PMID: 37491607]
REFERENCE   4  (residues 1 to 115)
  AUTHORS   Ma N, Wang YK, Xu S, Ni QZ, Zheng QW, Zhu B, Cao HJ, Jiang H, Zhang
            FK, Yuan YM, Zhang EB, Chen TW, Xia J, Ding XF, Chen ZH, Zhang XP,
            Wang K, Cheng SQ, Qiu L, Li ZG, Yu YC, Wang XF, Zhou B, Li JJ and
            Xie D.
  TITLE     PPDPF alleviates hepatic steatosis through inhibition of mTOR
            signaling
  JOURNAL   Nat Commun 12 (1), 3059 (2021)
   PUBMED   34031390
  REMARK    GeneRIF: PPDPF alleviates hepatic steatosis through inhibition of
            mTOR signaling.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 115)
  AUTHORS   Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK,
            Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L,
            Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre
            JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A,
            Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ,
            Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall
            S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA,
            Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR,
            Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana
            S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, MacArthur DG,
            Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC,
            Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL,
            de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown
            SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bucan M and Murray
            SA.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. PMID: 29144450]
REFERENCE   6  (residues 1 to 115)
  AUTHORS   Lewandowski JP, Du F, Zhang S, Powell MB, Falkenstein KN, Ji H and
            Vokes SA.
  TITLE     Spatiotemporal regulation of GLI target genes in the mammalian limb
            bud
  JOURNAL   Dev Biol 406 (1), 92-103 (2015)
   PUBMED   26238476
REFERENCE   7  (residues 1 to 115)
  AUTHORS   Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H,
            Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T,
            Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P,
            Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ,
            Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD,
            Flicek P, Skarnes WC, Mallon AM and Parkinson H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL450341.10 and CB202960.1.
            
            On Oct 4, 2017 this sequence version replaced XP_006500766.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100439.1, CK791036.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..115
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 103.62 cM"
     Protein         1..115
                     /product="pancreatic progenitor cell differentiation and
                     proliferation factor isoform a"
                     /note="exocrine differentiation and proliferation factor"
                     /calculated_mol_wt=12129
     Region          1..111
                     /region_name="PPDFL"
                     /note="Differentiation and proliferation regulator;
                     pfam15060"
                     /db_xref="CDD:434428"
     Site            9
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H3Y8; propagated from
                     UniProtKB/Swiss-Prot (Q9CR37.1)"
     Region          21..46
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CR37.1)"
     Region          73..115
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CR37.1)"
     CDS             1..115
                     /gene="Ppdpf"
                     /gene_synonym="0610012G23Rik; 2610317A05Rik;
                     2700038C09Rik; 3110053G12Rik"
                     /coded_by="NM_001356427.1:226..573"
                     /note="isoform a is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS17202.1"
                     /db_xref="GeneID:66496"
                     /db_xref="MGI:MGI:1913746"
ORIGIN      
        1 maaipssgsl vathdyyrrr lgsssssssg gsaeypgdav lqspglpkad pghwwasfff
       61 gkstlpfmtt vlespersae spqvsrspmt cgltpetmkq qpvihsgqtn prdls
//
LOCUS       NP_001390657             735 aa            linear   ROD 09-OCT-2023
DEFINITION  transcriptional repressor CTCF isoform 2 [Mus musculus].
ACCESSION   NP_001390657
VERSION     NP_001390657.1
DBSOURCE    REFSEQ: accession NM_001403728.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 735)
  AUTHORS   Hewitt SC, Gruzdev A, Willson CJ, Wu SP, Lydon JP, Galjart N and
            DeMayo FJ.
  TITLE     Chromatin architectural factor CTCF is essential for
            progesterone-dependent uterine maturation
  JOURNAL   FASEB J 37 (8), e23103 (2023)
   PUBMED   37489832
  REMARK    GeneRIF: Chromatin architectural factor CTCF is essential for
            progesterone-dependent uterine maturation.
REFERENCE   2  (residues 1 to 735)
  AUTHORS   Smits WK, Vermeulen C, Hagelaar R, Kimura S, Vroegindeweij EM,
            Buijs-Gladdines JGCAM, van de Geer E, Verstegen MJAM, Splinter E,
            van Reijmersdal SV, Buijs A, Galjart N, van Eyndhoven W, van Min M,
            Kuiper R, Kemmeren P, Mullighan CG, de Laat W and Meijerink JPP.
  TITLE     Elevated enhancer-oncogene contacts and higher oncogene expression
            levels by recurrent CTCF inactivating mutations in acute T cell
            leukemia
  JOURNAL   Cell Rep 42 (4), 112373 (2023)
   PUBMED   37060567
REFERENCE   3  (residues 1 to 735)
  AUTHORS   Wang B, Ji L and Bian Q.
  TITLE     SATB1 regulates 3D genome architecture in T cells by constraining
            chromatin interactions surrounding CTCF-binding sites
  JOURNAL   Cell Rep 42 (4), 112323 (2023)
   PUBMED   37000624
  REMARK    GeneRIF: SATB1 regulates 3D genome architecture in T cells by
            constraining chromatin interactions surrounding CTCF-binding sites.
REFERENCE   4  (residues 1 to 735)
  AUTHORS   Marina-Zarate E, Rodriguez-Ronchel A, Gomez MJ, Sanchez-Cabo F and
            Ramiro AR.
  TITLE     Low-affinity CTCF binding drives transcriptional regulation whereas
            high-affinity binding encompasses architectural functions
  JOURNAL   iScience 26 (3), 106106 (2023)
   PUBMED   36852270
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 735)
  AUTHORS   Hsieh TS, Cattoglio C, Slobodyanyuk E, Hansen AS, Darzacq X and
            Tjian R.
  TITLE     Enhancer-promoter interactions and transcription are largely
            maintained upon acute loss of CTCF, cohesin, WAPL or YY1
  JOURNAL   Nat Genet 54 (12), 1919-1932 (2022)
   PUBMED   36471071
  REMARK    GeneRIF: Enhancer-promoter interactions and transcription are
            largely maintained upon acute loss of CTCF, cohesin, WAPL or YY1.
REFERENCE   6  (residues 1 to 735)
  AUTHORS   Farrell CM, West AG and Felsenfeld G.
  TITLE     Conserved CTCF insulator elements flank the mouse and human
            beta-globin loci
  JOURNAL   Mol Cell Biol 22 (11), 3820-3831 (2002)
   PUBMED   11997516
  REMARK    GeneRIF: Conserved CTCF insulator elements flank the mouse and
            human beta-globin loci.
REFERENCE   7  (residues 1 to 735)
  AUTHORS   Burke LJ, Hollemann T, Pieler T and Renkawitz R.
  TITLE     Molecular cloning and expression of the chromatin insulator protein
            CTCF in Xenopus laevis
  JOURNAL   Mech Dev 113 (1), 95-98 (2002)
   PUBMED   11900981
REFERENCE   8  (residues 1 to 735)
  AUTHORS   Chao W, Huynh KD, Spencer RJ, Davidow LS and Lee JT.
  TITLE     CTCF, a candidate trans-acting factor for X-inactivation choice
  JOURNAL   Science 295 (5553), 345-347 (2002)
   PUBMED   11743158
  REMARK    GeneRIF: It's proposed that Tsix and CTCF together establish a
            regulatable epigenetic switch for X-inactivation.
REFERENCE   9  (residues 1 to 735)
  AUTHORS   Lutz M, Burke LJ, Barreto G, Goeman F, Greb H, Arnold R,
            Schultheiss H, Brehm A, Kouzarides T, Lobanenkov V and Renkawitz R.
  TITLE     Transcriptional repression by the insulator protein CTCF involves
            histone deacetylases
  JOURNAL   Nucleic Acids Res 28 (8), 1707-1713 (2000)
   PUBMED   10734189
REFERENCE   10 (residues 1 to 735)
  AUTHORS   Filippova GN, Fagerlie S, Klenova EM, Myers C, Dehner Y, Goodwin G,
            Neiman PE, Collins SJ and Lobanenkov VV.
  TITLE     An exceptionally conserved transcriptional repressor, CTCF, employs
            different combinations of zinc fingers to bind diverged promoter
            sequences of avian and mammalian c-myc oncogenes
  JOURNAL   Mol Cell Biol 16 (6), 2802-2813 (1996)
   PUBMED   8649389
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127419.3 and AC152826.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422597.916665.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..735
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.04 cM"
     Protein         1..735
                     /product="transcriptional repressor CTCF isoform 2"
                     /note="transcriptional repressor CTCF; CTCFL paralog;
                     11-zinc finger protein"
                     /calculated_mol_wt=83486
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          180..211
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61164.2)"
     Region          266..289
                     /region_name="zf-H2C2_5"
                     /note="C2H2-type zinc-finger domain; pfam13909"
                     /db_xref="CDD:404746"
     Region          268..288
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(268,271,284,288)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:275368"
     Site            order(273,275,277,279..280,283..284,287,301,303,307..308,
                     311..312,315,329,331,333,335..336,339..340,346)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          280..305
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:433230"
     Site            289
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          296..316
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          309..333
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:433230"
     Site            317
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          324..347
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          351..375
                     /region_name="zf-H2C2_5"
                     /note="C2H2-type zinc-finger domain; pfam13909"
                     /db_xref="CDD:404746"
     Region          353..373
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          <366..500
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Site            374
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          381..401
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            402
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          409..426
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          439..457
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          469..489
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(469,472,485,489)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:275368"
     Site            order(474,476,478,480..481,484..485,488,502,504,508..509,
                     512..513,516,530,532,534,536..537,540..541,545)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          497..517
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          509..534
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:433230"
     Region          525..546
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          557..573
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            609
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Site            610
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Site            612
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          698..725
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61164.2)"
     CDS             1..735
                     /gene="Ctcf"
                     /coded_by="NM_001403728.1:743..2950"
                     /note="isoform 2 is encoded by transcript variant 8"
                     /db_xref="GeneID:13018"
                     /db_xref="MGI:MGI:109447"
ORIGIN      
        1 megeaveaiv eesetfikgk erktyqrrre ggqeedachl pqnqtdggev vqdvnssvqm
       61 vmmeqldptl lqmktevmeg tvapeaeaav ddtqiitlqv vnmeeqpini gelqlvqvpv
      121 pvtvpvatts veelqgayen evskeglaes epmichtlpl pegfqvvkvg angevetleq
      181 gelppqedss wqkdpdyqpp akktkktkks klryteegkd vdvsvydfee eqqegllsev
      241 naekvvgnmk ppkptkikkk gvkktfqcel csytcprrsn ldrhmkshtd erphkchlcg
      301 rafrtvtllr nhlnthtgtr phkcpdcdma fvtsgelvrh rrykhthekp fkcsmcdyas
      361 vevsklkrhi rshtgerpfq cslcsyasrd tyklkrhmrt hsgekpyecy icharftqsg
      421 tmkmhilqkh tenvakfhcp hcdtviarks dlgvhlrkqh syieqgkkcr ycdavfhery
      481 aliqhqkshk nekrfkcdqc dyacrqerhm imhkrthtge kpyacshcdk tfrqkqlldm
      541 hfkryhdpnf vpaafvcskc gktftrrntm arhadncagp dgvegengge tkkskrgrkr
      601 kmrskkedss dsenaepdld dneeeeepav eiepepepqp qpppppqpva papppakkrr
      661 grppgrtnqp kqnqptaiiq vedqntgaie niivevkkep daepaegeee eaqaattdap
      721 ngdltpemil smmdr
//
LOCUS       NP_036120                502 aa            linear   ROD 09-OCT-2023
DEFINITION  cystine/glutamate transporter [Mus musculus].
ACCESSION   NP_036120
VERSION     NP_036120.1
DBSOURCE    REFSEQ: accession NM_011990.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 502)
  AUTHORS   de Baat A, Meier DT, Rachid L, Fontana A, Boni-Schnetzler M and
            Donath MY.
  TITLE     Cystine/glutamate antiporter System xc- deficiency impairs insulin
            secretion in mice
  JOURNAL   Diabetologia 66 (11), 2062-2074 (2023)
   PUBMED   37650924
REFERENCE   2  (residues 1 to 502)
  AUTHORS   Ruiu R, Cossu C, Iacoviello A, Conti L, Bolli E, Ponzone L, Magri
            J, Rumandla A, Calautti E and Cavallo F.
  TITLE     Cystine/glutamate antiporter xCT deficiency reduces metastasis
            without impairing immune system function in breast cancer mouse
            models
  JOURNAL   J Exp Clin Cancer Res 42 (1), 254 (2023)
   PUBMED   37770957
  REMARK    GeneRIF: Cystine/glutamate antiporter xCT deficiency reduces
            metastasis without impairing immune system function in breast
            cancer mouse models.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 502)
  AUTHORS   Frare C, Pitt SK and Hewett SJ.
  TITLE     Sex- and age-dependent contribution of System xc- to cognitive,
            sensory, and social behaviors revealed by comprehensive behavioral
            analyses of System xc- null mice
  JOURNAL   Front Behav Neurosci 17, 1238349 (2023)
   PUBMED   37649973
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 502)
  AUTHORS   Orlowska,K., Fling,R.R., Nault,R., Schilmiller,A.L. and
            Zacharewski,T.R.
  TITLE     Cystine/Glutamate Xc- Antiporter Induction Compensates for
            Transsulfuration Pathway Repression by
            2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) to Ensure Cysteine for
            Hepatic Glutathione Biosynthesis
  JOURNAL   Chem Res Toxicol 36 (6), 900-915 (2023)
   PUBMED   37184393
  REMARK    GeneRIF: Cystine/Glutamate Xc[-] Antiporter Induction Compensates
            for Transsulfuration Pathway Repression by
            2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) to Ensure Cysteine for
            Hepatic Glutathione Biosynthesis.
REFERENCE   5  (residues 1 to 502)
  AUTHORS   Zhang X, Zheng X, Ying X, Xie W, Yin Y and Wang X.
  TITLE     CEBPG suppresses ferroptosis through transcriptional control of
            SLC7A11 in ovarian cancer
  JOURNAL   J Transl Med 21 (1), 334 (2023)
   PUBMED   37210575
  REMARK    GeneRIF: CEBPG suppresses ferroptosis through transcriptional
            control of SLC7A11 in ovarian cancer.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 502)
  AUTHORS   Sato H, Kuriyama-Matsumura K, Hashimoto T, Sasaki H, Wang H, Ishii
            T, Mann GE and Bannai S.
  TITLE     Effect of oxygen on induction of the cystine transporter by
            bacterial lipopolysaccharide in mouse peritoneal macrophages
  JOURNAL   J Biol Chem 276 (13), 10407-10412 (2001)
   PUBMED   11136724
REFERENCE   7  (residues 1 to 502)
  AUTHORS   Sato H, Tamba M, Ishii T and Bannai S.
  TITLE     Cloning and expression of a plasma membrane cystine/glutamate
            exchange transporter composed of two distinct proteins
  JOURNAL   J Biol Chem 274 (17), 11455-11458 (1999)
   PUBMED   10206947
REFERENCE   8  (residues 1 to 502)
  AUTHORS   Odorizzi G, Cowles CR and Emr SD.
  TITLE     The AP-3 complex: a coat of many colours
  JOURNAL   Trends Cell Biol 8 (7), 282-288 (1998)
   PUBMED   9714600
  REMARK    Review article
REFERENCE   9  (residues 1 to 502)
  AUTHORS   Swank RT, Novak EK, McGarry MP, Rusiniak ME and Feng L.
  TITLE     Mouse models of Hermansky Pudlak syndrome: a review
  JOURNAL   Pigment Cell Res 11 (2), 60-80 (1998)
   PUBMED   9585243
  REMARK    Review article
REFERENCE   10 (residues 1 to 502)
  AUTHORS   Swank RT, Reddington M and Novak EK.
  TITLE     Inherited prolonged bleeding time and platelet storage pool
            deficiency in the subtle gray (sut) mouse
  JOURNAL   Lab Anim Sci 46 (1), 56-60 (1996)
   PUBMED   8699821
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB630675.1, AB022345.1 and AC101992.11.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY766236.1, BC141408.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 21.72 cM"
     Protein         1..502
                     /product="cystine/glutamate transporter"
                     /note="sodium independent anionic amino acid transport
                     system; amino acid transport system xc-;
                     cysteine/glutamate transporter; solute carrier family 7
                     member 11; subtle gray protein"
                     /calculated_mol_wt=55325
     Region          1..498
                     /region_name="2A0308"
                     /note="L-type amino acid transporter; TIGR00911"
                     /db_xref="CDD:273332"
     Site            26
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19144319; propagated from
                     UniProtKB/Swiss-Prot (Q9WTR6.1)"
     Site            44..64
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WTR6.1)"
     Site            75..95
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WTR6.1)"
     Site            131..150
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WTR6.1)"
     Site            164..179
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WTR6.1)"
     Site            194..210
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WTR6.1)"
     Site            235..255
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WTR6.1)"
     Site            266..286
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WTR6.1)"
     Site            318..338
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WTR6.1)"
     Site            365..385
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WTR6.1)"
     Site            388..408
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WTR6.1)"
     Site            423..443
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WTR6.1)"
     Site            450..470
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WTR6.1)"
     CDS             1..502
                     /gene="Slc7a11"
                     /gene_synonym="9930009M05Rik; sut; xCT"
                     /coded_by="NM_011990.2:353..1861"
                     /db_xref="CCDS:CCDS17335.1"
                     /db_xref="GeneID:26570"
                     /db_xref="MGI:MGI:1347355"
ORIGIN      
        1 mvrkpvvati skggylqgnm sgrlpsmgdq eppgqekvvl kkkitllrgv siiigtvigs
       61 gifispkgil qntgsvgmsl vfwsacgvls lfgalsyael gtsikksggh ytyilevfgp
      121 llafvrvwve llvirpgata vislafgryi lepffiqcei pelaiklvta vgitvvmvln
      181 stsvswsari qifltfcklt ailiiivpgv iqlikgqthh fkdafsgrdt slmglplafy
      241 ygmyayagwf ylnfiteevd npektiplai cismaiitvg yvltnvayft tisaeellqs
      301 savavtfser llgkfslavp ifvalscfgs mnggvfavsr lfyvasregh lpeilsmihv
      361 hkhtplpavi vlhpltmvml fsgdlyslln flsfarwlfm glavagliyl rykrpdmhrp
      421 fkvplfipal fsftclfmvv lslysdpfst gvgflitltg vpayylfivw dkkpkwfrrl
      481 sdritrtlqi ilevvpedsk el
//
LOCUS       NP_059095                127 aa            linear   ROD 09-OCT-2023
DEFINITION  fatty acid-binding protein, liver [Mus musculus].
ACCESSION   NP_059095
VERSION     NP_059095.1
DBSOURCE    REFSEQ: accession NM_017399.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 127)
  AUTHORS   You H, Wen X, Wang X, Zhu C, Chen H, Bu L, Zhang J and Qu S.
  TITLE     Derlin-1 ameliorates nonalcoholic hepatic steatosis by promoting
            ubiquitylation and degradation of FABP1
  JOURNAL   Free Radic Biol Med 207, 260-271 (2023)
   PUBMED   37499886
  REMARK    GeneRIF: Derlin-1 ameliorates nonalcoholic hepatic steatosis by
            promoting ubiquitylation and degradation of FABP1.
REFERENCE   2  (residues 1 to 127)
  AUTHORS   Zinina VV, Sauer M, Nigmatullina L, Kreim N and Soshnikova N.
  TITLE     TCF7L1 Controls the Differentiation of Tuft Cells in Mouse Small
            Intestine
  JOURNAL   Cells 12 (11), 1452 (2023)
   PUBMED   37296573
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 127)
  AUTHORS   Gajda AM, Tawfeeq HR, Lackey AI, Zhou YX, Kanaan H, Pappas A, Xu H,
            Kodukula S and Storch J.
  TITLE     The proximal intestinal Fatty Acid-Binding Proteins liver FABP
            (LFABP) and intestinal FABP (IFABP) differentially modulate whole
            body energy homeostasis but are not centrally involved in net
            dietary lipid absorption: Studies of the LFABP/IFABP double
            knockout mouse
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1868 (1), 159238 (2023)
   PUBMED   36206853
  REMARK    GeneRIF: The proximal intestinal Fatty Acid-Binding Proteins liver
            FABP (LFABP) and intestinal FABP (IFABP) differentially modulate
            whole body energy homeostasis but are not centrally involved in net
            dietary lipid absorption: Studies of the LFABP/IFABP double
            knockout mouse.
REFERENCE   4  (residues 1 to 127)
  AUTHORS   Salazar-Petres E, Pereira-Carvalho D, Lopez-Tello J and
            Sferruzzi-Perri AN.
  TITLE     Placental structure, function, and mitochondrial phenotype relate
            to fetal size in each fetal sex in micedagger
  JOURNAL   Biol Reprod 106 (6), 1292-1311 (2022)
   PUBMED   35293971
REFERENCE   5  (residues 1 to 127)
  AUTHORS   Kawakami R, Matsui M, Konno A, Kaneko R, Shrestha S, Shrestha S,
            Sunaga H, Hanaoka H, Goto S, Hosojima M, Kabasawa H, Obokata M,
            Koitabashi N, Matsui H, Sasaki T, Saito A, Yanagita M, Hirai H,
            Kurabayashi M and Iso T.
  TITLE     Urinary FABP1 is a biomarker for impaired proximal tubular protein
            reabsorption and is synergistically enhanced by concurrent liver
            injury
  JOURNAL   J Pathol 255 (4), 362-373 (2021)
   PUBMED   34370295
REFERENCE   6  (residues 1 to 127)
  AUTHORS   Mallordy A, Poirier H, Besnard P, Niot I and Carlier H.
  TITLE     Evidence for transcriptional induction of the liver
            fatty-acid-binding-protein gene by bezafibrate in the small
            intestine
  JOURNAL   Eur J Biochem 227 (3), 801-807 (1995)
   PUBMED   7867641
REFERENCE   7  (residues 1 to 127)
  AUTHORS   Serikawa T, Kuramoto T, Hilbert P, Mori M, Yamada J, Dubay CJ,
            Lindpainter K, Ganten D, Guenet JL, Lathrop GM et al.
  TITLE     Rat gene mapping using PCR-analyzed microsatellites
  JOURNAL   Genetics 131 (3), 701-721 (1992)
   PUBMED   1628813
REFERENCE   8  (residues 1 to 127)
  AUTHORS   Norman DJ, Fletcher C and Heintz N.
  TITLE     Genetic mapping of the lurcher locus on mouse chromosome 6 using an
            intersubspecific backcross
  JOURNAL   Genomics 9 (1), 147-153 (1991)
   PUBMED   1672287
REFERENCE   9  (residues 1 to 127)
  AUTHORS   Bansal MP, Cook RG, Danielson KG and Medina D.
  TITLE     A 14-kilodalton selenium-binding protein in mouse liver is fatty
            acid-binding protein
  JOURNAL   J Biol Chem 264 (23), 13780-13784 (1989)
   PUBMED   2760043
REFERENCE   10 (residues 1 to 127)
  AUTHORS   Sweetser DA, Birkenmeier EH, Klisak IJ, Zollman S, Sparkes RS,
            Mohandas T, Lusis AJ and Gordon JI.
  TITLE     The human and rodent intestinal fatty acid binding protein genes. A
            comparative analysis of their structure, expression, and linkage
            relationships
  JOURNAL   J Biol Chem 262 (33), 16060-16071 (1987)
   PUBMED   2824476
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK131868.1 and AW113370.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY105254.1, CD297710.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..127
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 32.14 cM"
     Protein         1..127
                     /product="fatty acid-binding protein, liver"
                     /note="fatty acid-binding protein 1; 14 kDa
                     selenium-binding protein; liver-type fatty acid-binding
                     protein"
                     /calculated_mol_wt=14114
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:P80425; propagated from
                     UniProtKB/Swiss-Prot (P12710.2)"
     Region          2..127
                     /region_name="FABP1"
                     /note="fatty acid-binding protein 1; cd19444"
                     /db_xref="CDD:381219"
     Site            order(3,15,18..19,22,28..29,31..32,35,37,39,41,48,50,52,
                     54..57,59,61,63,71..74,91,93,100,102,109,111,113,122,124)
                     /site_type="other"
                     /note="ligand binding cavity [chemical binding]"
                     /db_xref="CDD:381219"
     Site            11
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P12710.2)"
     Site            39
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02692; propagated from
                     UniProtKB/Swiss-Prot (P12710.2)"
     Site            51
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P07148; propagated from
                     UniProtKB/Swiss-Prot (P12710.2)"
     Site            84
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P12710.2)"
     Site            100
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P12710.2)"
     CDS             1..127
                     /gene="Fabp1"
                     /gene_synonym="Fabpl; L-FABP"
                     /coded_by="NM_017399.5:49..432"
                     /db_xref="CCDS:CCDS20226.1"
                     /db_xref="GeneID:14080"
                     /db_xref="MGI:MGI:95479"
ORIGIN      
        1 mnfsgkyqlq sqenfepfmk aiglpedliq kgkdikgvse ivhegkkikl titygpkvvr
       61 neftlgeece letmtgekvk avvklegdnk mvttfkgiks vtelngdtit ntmtlgdivy
      121 krvskri
//
LOCUS       NP_001277312             680 aa            linear   ROD 09-OCT-2023
DEFINITION  epithelial splicing regulatory protein 1 isoform 2 [Mus musculus].
ACCESSION   NP_001277312 XP_006537777
VERSION     NP_001277312.1
DBSOURCE    REFSEQ: accession NM_001290383.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 680)
  AUTHORS   Wang W, Taufalele PV, Millet M, Homsy K, Smart K, Berestesky ED,
            Schunk CT, Rowe MM, Bordeleau F and Reinhart-King CA.
  TITLE     Matrix stiffness regulates tumor cell intravasation through
            expression and ESRP1-mediated alternative splicing of MENA
  JOURNAL   Cell Rep 42 (4), 112338 (2023)
   PUBMED   37027295
  REMARK    GeneRIF: Matrix stiffness regulates tumor cell intravasation
            through expression and ESRP1-mediated alternative splicing of MENA.
REFERENCE   2  (residues 1 to 680)
  AUTHORS   Zhao Y, Li M, Wu W, Miao W and Liu H.
  TITLE     Downregulated ESRP1/2 promotes lung metastasis of bladder carcinoma
            through altering FGFR2 splicing and macrophage polarization
  JOURNAL   Front Immunol 14, 1161273 (2023)
   PUBMED   37090731
  REMARK    GeneRIF: Downregulated ESRP1/2 promotes lung metastasis of bladder
            carcinoma through altering FGFR2 splicing and macrophage
            polarization.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 680)
  AUTHORS   Peart NJ, Hwang JY, Quesnel-Vallieres M, Sears MJ, Yang Y, Stoilov
            P, Barash Y, Park JW, Lynch KW and Carstens RP.
  TITLE     The global Protein-RNA interaction map of ESRP1 defines a
            post-transcriptional program that is essential for epithelial cell
            function
  JOURNAL   iScience 25 (10), 105205 (2022)
   PUBMED   36238894
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 680)
  AUTHORS   Spruce T, Plass M, Gohr A, Ray D, Martinez de Lagran M, Rot G,
            Novoa A, Burguera D, Permanyer J, Miret M, Zheng H, Swanson MS,
            Morris Q, Mallo M, Dierssen M, Hughes TR, Pernaute B and Irimia M.
  TITLE     The X-linked splicing regulator MBNL3 has been co-opted to restrict
            placental growth in eutherians
  JOURNAL   PLoS Biol 20 (4), e3001615 (2022)
   PUBMED   35476669
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 680)
  AUTHORS   Yu L, Zhang H, Guan X, Qin D, Zhou J and Wu X.
  TITLE     Loss of ESRP1 blocks mouse oocyte development and leads to female
            infertility
  JOURNAL   Development 148 (2) (2021)
   PUBMED   33318146
  REMARK    GeneRIF: Loss of ESRP1 blocks mouse oocyte development and leads to
            female infertility.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 680)
  AUTHORS   Warzecha CC, Sato TK, Nabet B, Hogenesch JB and Carstens RP.
  TITLE     ESRP1 and ESRP2 are epithelial cell-type-specific regulators of
            FGFR2 splicing
  JOURNAL   Mol Cell 33 (5), 591-601 (2009)
   PUBMED   19285943
  REMARK    GeneRIF: Epithelial splicing regulatory proteins 1/2 (ESRP1/2) are
            epithelial cell-type-specific regulators of FGFR2 splicing.
REFERENCE   7  (residues 1 to 680)
  AUTHORS   Sherwood RI, Jitianu C, Cleaver O, Shaywitz DA, Lamenzo JO, Chen
            AE, Golub TR and Melton DA.
  TITLE     Prospective isolation and global gene expression analysis of
            definitive and visceral endoderm
  JOURNAL   Dev Biol 304 (2), 541-555 (2007)
   PUBMED   17328885
REFERENCE   8  (residues 1 to 680)
  AUTHORS   Evsikov AV, Graber JH, Brockman JM, Hampl A, Holbrook AE, Singh P,
            Eppig JJ, Solter D and Knowles BB.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   9  (residues 1 to 680)
  AUTHORS   McKee AE, Minet E, Stern C, Riahi S, Stiles CD and Silver PA.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   10 (residues 1 to 680)
  AUTHORS   Piao Y, Ko NT, Lim MK and Ko MS.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK140848.1, CJ081693.1, DV654302.1, DV657411.1, DV648780.1 and
            AA647208.1.
            
            On Mar 12, 2014 this sequence version replaced XP_006537777.1.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 5' coding region, compared to variant 1. It
            encodes isoform 2, which is shorter by an amino acid, compared to
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK140848.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..680
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 5.11 cM"
     Protein         1..680
                     /product="epithelial splicing regulatory protein 1 isoform
                     2"
                     /note="RNA binding motif protein 35A"
                     /calculated_mol_wt=75419
     Region          29..>145
                     /region_name="DnaQ_like_exo"
                     /note="DnaQ-like (or DEDD) 3'-5' exonuclease domain
                     superfamily; cl10012"
                     /db_xref="CDD:447876"
     Region          216..307
                     /region_name="RRM_SF"
                     /note="RNA recognition motif (RRM) superfamily; cl17169"
                     /db_xref="CDD:450164"
     Region          309..418
                     /region_name="RRM2_ESRP1"
                     /note="RNA recognition motif 2 (RRM2) found in epithelial
                     splicing regulatory protein 1 (ESRP1) and similar
                     proteins; cd12739"
                     /db_xref="CDD:410136"
     Region          443..523
                     /region_name="RRM3_ESRP1_ESRP2"
                     /note="RNA recognition motif 3 (RRM3) found in epithelial
                     splicing regulatory protein ESRP1, ESRP2 and similar
                     proteins; cd12742"
                     /db_xref="CDD:410138"
     Site            542
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H6T0; propagated from
                     UniProtKB/Swiss-Prot (Q3US41.2)"
     Site            581
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:Q6NXG1; propagated from
                     UniProtKB/Swiss-Prot (Q3US41.2)"
     Region          632..>671
                     /region_name="RRM_SF"
                     /note="RNA recognition motif (RRM) superfamily; cl17169"
                     /db_xref="CDD:450164"
     CDS             1..680
                     /gene="Esrp1"
                     /gene_synonym="2210008M09Rik; A630065D16; Rbm35a"
                     /coded_by="NM_001290383.1:348..2390"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="GeneID:207920"
                     /db_xref="MGI:MGI:1917326"
ORIGIN      
        1 mtaspdylvv lfgitagatg aklgsdekel illlwkvvdl ankkvgqlhe vlvrpdqlel
       61 tedckeetki daenlssapq ldqalrqfnq svsnelnigv gtsfclctdg qlhirqilhp
      121 easkknvllp ecfysffdlr kefkkccpgs pdidkldvaa mteslnfeks dsvsrygasq
      181 vedmgniila misepynhrf sdpervnykf esgtckmeli ddstvvrarg lpwqssdqdi
      241 arffkglnia kggaalclna qgrrngealv rfvseehrdl alqrhkhhmg tryievykat
      301 gedflkiagg tsnevaqfls kenqvivrmr glpftataee vvaffgqhcp itggkegilf
      361 vtypdgrptg dafvlfacee yaqnalrkhk ellgkryiel frstaaevqq vlnrfssapl
      421 iplptppiip vlpqqfvppt nvrdcirlrg lpyaatiedi ldflgefstd irthgvhmvl
      481 nhqgrpsgda fiqmkstdra fmaaqkyhkk tmkdryvevf qcsaeemnfv lmggtlnrng
      541 lspppcklpc lsppsytfpa ptavipteaa iyqpslllnp ralqpstayy pagtqlfmny
      601 tayypsppgs pnslgyfpta anlssvppqp gtvvrmqgla yntgvkeiln ffqgyqyate
      661 dglvhtndqa rtlpkewvci
//
LOCUS       NP_001157103             764 aa            linear   ROD 09-OCT-2023
DEFINITION  DNA-binding protein SATB1 isoform 1 [Mus musculus].
ACCESSION   NP_001157103
VERSION     NP_001157103.1
DBSOURCE    REFSEQ: accession NM_001163631.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 764)
  AUTHORS   Naito T, Ise M, Tanaka Y, Kohwi-Shigematsu T and Kondo M.
  TITLE     Crucial Roles of SATB1 in Regulation of Thymocyte Migration after
            Positive Selection
  JOURNAL   J Immunol 211 (2), 209-218 (2023)
   PUBMED   37256264
  REMARK    GeneRIF: Crucial Roles of SATB1 in Regulation of Thymocyte
            Migration after Positive Selection.
REFERENCE   2  (residues 1 to 764)
  AUTHORS   Nomura A, Kobayashi T, Seo W, Ohno-Oishi M, Kakugawa K, Muroi S,
            Yoshida H, Endo TA, Moro K and Taniuchi I.
  TITLE     Identification of a novel enhancer essential for Satb1 expression
            in TH2 cells and activated ILC2s
  JOURNAL   Life Sci Alliance 6 (8), e202301897 (2023)
   PUBMED   37193606
  REMARK    GeneRIF: Identification of a novel enhancer essential for Satb1
            expression in TH2 cells and activated ILC2s.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 764)
  AUTHORS   Knowles SJ, Stafford AM, Zaman T, Angara K, Williams MR, Newbern JM
            and Vogt D.
  TITLE     Distinct hyperactive RAS/MAPK alleles converge on common GABAergic
            interneuron core programs
  JOURNAL   Development 150 (10) (2023)
   PUBMED   37254876
REFERENCE   4  (residues 1 to 764)
  AUTHORS   Wang B, Ji L and Bian Q.
  TITLE     SATB1 regulates 3D genome architecture in T cells by constraining
            chromatin interactions surrounding CTCF-binding sites
  JOURNAL   Cell Rep 42 (4), 112323 (2023)
   PUBMED   37000624
  REMARK    GeneRIF: SATB1 regulates 3D genome architecture in T cells by
            constraining chromatin interactions surrounding CTCF-binding sites.
REFERENCE   5  (residues 1 to 764)
  AUTHORS   Vasilopoulos N, Kaplanian A, Vinos M, Katsaiti Y, Christodoulou O,
            Denaxa M and Skaliora I.
  TITLE     The role of selective SATB1 deletion in somatostatin expressing
            interneurons on endogenous network activity and the transition to
            epilepsy
  JOURNAL   J Neurosci Res 101 (4), 424-447 (2023)
   PUBMED   36541427
  REMARK    GeneRIF: The role of selective SATB1 deletion in somatostatin
            expressing interneurons on endogenous network activity and the
            transition to epilepsy.
REFERENCE   6  (residues 1 to 764)
  AUTHORS   Seo J, Lozano MM and Dudley JP.
  TITLE     Nuclear matrix binding regulates SATB1-mediated transcriptional
            repression
  JOURNAL   J Biol Chem 280 (26), 24600-24609 (2005)
   PUBMED   15851481
  REMARK    GeneRIF: SATB1-mediated transcriptional repression is regulated by
            nuclear matrix binding
REFERENCE   7  (residues 1 to 764)
  AUTHORS   Nie H, Maika SD, Tucker PW and Gottlieb PD.
  TITLE     A role for SATB1, a nuclear matrix association region-binding
            protein, in the development of CD8SP thymocytes and peripheral T
            lymphocytes
  JOURNAL   J Immunol 174 (8), 4745-4752 (2005)
   PUBMED   15814699
  REMARK    GeneRIF: essential role for SATB1 late in the development and
            maturation of CD8SP T cells
REFERENCE   8  (residues 1 to 764)
  AUTHORS   Cai S, Han HJ and Kohwi-Shigematsu T.
  TITLE     Tissue-specific nuclear architecture and gene expression regulated
            by SATB1
  JOURNAL   Nat Genet 34 (1), 42-51 (2003)
   PUBMED   12692553
  REMARK    GeneRIF: in thymocyte nuclei, SATB1 has a cage-like 'network'
            distribution circumscribing heterochromatin and selectively tethers
            specialized DNA sequences onto its network
REFERENCE   9  (residues 1 to 764)
  AUTHORS   Alvarez JD, Yasui DH, Niida H, Joh T, Loh DY and Kohwi-Shigematsu
            T.
  TITLE     The MAR-binding protein SATB1 orchestrates temporal and spatial
            expression of multiple genes during T-cell development
  JOURNAL   Genes Dev 14 (5), 521-535 (2000)
   PUBMED   10716941
REFERENCE   10 (residues 1 to 764)
  AUTHORS   Nakagomi K, Kohwi Y, Dickinson LA and Kohwi-Shigematsu T.
  TITLE     A novel DNA-binding motif in the nuclear matrix attachment
            DNA-binding protein SATB1
  JOURNAL   Mol Cell Biol 14 (3), 1852-1860 (1994)
   PUBMED   8114718
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB611616.1, AK134040.1, AK037740.1, AK081385.1, AC131975.28 and
            AW045567.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1-4 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.150381.1,
                                           SRR7974084.10596.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..764
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 26.81 cM"
     Protein         1..764
                     /product="DNA-binding protein SATB1 isoform 1"
                     /note="DNA-binding protein Satb1"
                     /calculated_mol_wt=85749
     Region          1..56
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60611.2)"
     Region          20..40
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60611.2)"
     Region          72..170
                     /region_name="ULD"
                     /note="Ubiquitin-like oligomerization domain of SATB;
                     pfam16534"
                     /db_xref="CDD:435405"
     Site            order(75,77,94..98,100,132,134,137..138,144..147,155..156,
                     159..161,163..164)
                     /site_type="other"
                     /note="tetramer interface [polypeptide binding]"
                     /db_xref="CDD:211426"
     Site            136
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q01826; propagated from
                     UniProtKB/Swiss-Prot (Q60611.2)"
     Region          139..143
                     /region_name="Protein interaction. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60611.2)"
     Region          176..247
                     /region_name="CUTL"
                     /note="CUT1-like DNA-binding domain of SATB; pfam16557"
                     /db_xref="CDD:435427"
     Site            185
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q01826; propagated from
                     UniProtKB/Swiss-Prot (Q60611.2)"
     Region          224..278
                     /region_name="Nuclear matrix targeting sequence (NMTS)"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60611.2)"
     Region          224..278
                     /region_name="Nuclear matrix targeting sequence (NMTS).
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60611.2)"
     Site            254..255
                     /site_type="cleavage"
                     /note="Cleavage, by caspases; propagated from
                     UniProtKB/Swiss-Prot (Q60611.2)"
     Region          266..307
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60611.2)"
     Region          372..444
                     /region_name="CUT"
                     /note="CUT domain; pfam02376"
                     /db_xref="CDD:426745"
     Region          450..474
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60611.2)"
     Region          497..567
                     /region_name="CUT"
                     /note="CUT domain; pfam02376"
                     /db_xref="CDD:426745"
     Region          591..650
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60611.2)"
     Site            638
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q60611.2)"
     Region          645..702
                     /region_name="HOX"
                     /note="Homeodomain; smart00389"
                     /db_xref="CDD:197696"
     Site            order(647..650,652,670,676,689,691..692,695..696,698..700,
                     702..703)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     Site            order(648,651,692,695..696,699)
                     /site_type="other"
                     /note="specific DNA base contacts [nucleotide binding]"
                     /db_xref="CDD:238039"
     CDS             1..764
                     /gene="Satb1"
                     /gene_synonym="2610306G12Rik"
                     /coded_by="NM_001163631.1:190..2484"
                     /note="isoform 1 is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS28876.1"
                     /db_xref="GeneID:20230"
                     /db_xref="MGI:MGI:105084"
ORIGIN      
        1 mdhlneatqg kehsemsnnv sdpkgppaki arleqngspl grgrlgstgg kmqgvplkhs
       61 ghlmktnlrk gtmlpvfcvv ehyenaieyd ckeehaefvl vrkdmlfnql iemallslgy
      121 shssaaqakg liqvgkwnpv plsyvtdapd atvadmlqdv yhvvtlkiql hscpkledlp
      181 peqwshttvr nalkdllkdm nqsslakecp lsqsmissiv nstyyanvsa akcqefgrwy
      241 khfkktkdmm vemdslsels qqganhvnfg qqpvpgntae qppspaqlsh gsqpsvrtpl
      301 pnlhpglvst pispqlvnqq lvmaqllnqq yavnrllaqq slnqqylnhp ppvsrsmnkp
      361 leqqvstnte vsseiyqwvr delkragisq avfarvafnr tqgllseilr keedpktasq
      421 sllvnlramq nflqlpeaer driyqderer slnaasamgp apllstppsr ppqvktatla
      481 terngkpenn tmninasiyd eiqqemkrak vsqalfakva atksqgwlce llrwkedpsp
      541 enrtlwenls mirrflslpq perdaiyeqe snavhhhgdr pphiihvpae qiqqqqqqqq
      601 qqqqqqqppp pppqpqpqpq agprlpprqp tvassaesde enrqktrprt kisvealgil
      661 qsfiqdvgly pdeeaiqtls aqldlpkyti ikffqnqryy lkhhgklkdn sglevdvaey
      721 kdeellkdle esvqdknant lfsvkleeel svegstdvna dlkd
//
LOCUS       NP_082742                317 aa            linear   ROD 09-OCT-2023
DEFINITION  guanine nucleotide exchange factor C9orf72 homolog isoform 2 [Mus
            musculus].
ACCESSION   NP_082742
VERSION     NP_082742.2
DBSOURCE    REFSEQ: accession NM_028466.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 317)
  AUTHORS   Hendricks E, Quihuis AM, Hung ST, Chang J, Dorjsuren N, Der B,
            Staats KA, Shi Y, Sta Maria NS, Jacobs RE and Ichida JK.
  TITLE     The C9ORF72 repeat expansion alters neurodevelopment
  JOURNAL   Cell Rep 42 (8), 112983 (2023)
   PUBMED   37590144
  REMARK    GeneRIF: The C9ORF72 repeat expansion alters neurodevelopment.
REFERENCE   2  (residues 1 to 317)
  AUTHORS   Pang W and Hu F.
  TITLE     C9ORF72 suppresses JAK-STAT mediated inflammation
  JOURNAL   iScience 26 (5), 106579 (2023)
   PUBMED   37250330
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 317)
  AUTHORS   He L, Liang J, Chen C, Chen J, Shen Y, Sun S and Li L.
  TITLE     C9orf72 functions in the nucleus to regulate DNA damage repair
  JOURNAL   Cell Death Differ 30 (3), 716-730 (2023)
   PUBMED   36220889
  REMARK    GeneRIF: C9orf72 functions in the nucleus to regulate DNA damage
            repair.
REFERENCE   4  (residues 1 to 317)
  AUTHORS   Shu X, Wei C, Tu WY, Zhong K, Qi S, Wang A, Bai L, Zhang SX, Luo B,
            Xu ZZ, Zhang K and Shen C.
  TITLE     Negative regulation of TREM2-mediated C9orf72 poly-GA clearance by
            the NLRP3 inflammasome
  JOURNAL   Cell Rep 42 (2), 112133 (2023)
   PUBMED   36800288
  REMARK    GeneRIF: Negative regulation of TREM2-mediated C9orf72 poly-GA
            clearance by the NLRP3 inflammasome.
REFERENCE   5  (residues 1 to 317)
  AUTHORS   Liu Y, Xing H, Ernst AF, Liu C, Maugee C, Yokoi F, Lakshmana M and
            Li Y.
  TITLE     Hyperactivity of Purkinje cell and motor deficits in C9orf72
            knockout mice
  JOURNAL   Mol Cell Neurosci 121, 103756 (2022)
   PUBMED   35843530
  REMARK    GeneRIF: Hyperactivity of Purkinje cell and motor deficits in
            C9orf72 knockout mice.
REFERENCE   6  (residues 1 to 317)
  AUTHORS   Chew J, Gendron TF, Prudencio M, Sasaguri H, Zhang YJ,
            Castanedes-Casey M, Lee CW, Jansen-West K, Kurti A, Murray ME,
            Bieniek KF, Bauer PO, Whitelaw EC, Rousseau L, Stankowski JN,
            Stetler C, Daughrity LM, Perkerson EA, Desaro P, Johnston A,
            Overstreet K, Edbauer D, Rademakers R, Boylan KB, Dickson DW, Fryer
            JD and Petrucelli L.
  TITLE     Neurodegeneration. C9ORF72 repeat expansions in mice cause TDP-43
            pathology, neuronal loss, and behavioral deficits
  JOURNAL   Science 348 (6239), 1151-1154 (2015)
   PUBMED   25977373
REFERENCE   7  (residues 1 to 317)
  AUTHORS   Farg MA, Sundaramoorthy V, Sultana JM, Yang S, Atkinson RA, Levina
            V, Halloran MA, Gleeson PA, Blair IP, Soo KY, King AE and Atkin JD.
  TITLE     C9ORF72, implicated in amytrophic lateral sclerosis and
            frontotemporal dementia, regulates endosomal trafficking
  JOURNAL   Hum Mol Genet 23 (13), 3579-3595 (2014)
   PUBMED   24549040
  REMARK    Erratum:[Hum Mol Genet. 2017 Oct 15;26(20):4093-4094. PMID:
            28973528]
REFERENCE   8  (residues 1 to 317)
  AUTHORS   Suzuki N, Maroof AM, Merkle FT, Koszka K, Intoh A, Armstrong I,
            Moccia R, Davis-Dusenbery BN and Eggan K.
  TITLE     The mouse C9ORF72 ortholog is enriched in neurons known to
            degenerate in ALS and FTD
  JOURNAL   Nat Neurosci 16 (12), 1725-1727 (2013)
   PUBMED   24185425
REFERENCE   9  (residues 1 to 317)
  AUTHORS   Lagier-Tourenne C, Baughn M, Rigo F, Sun S, Liu P, Li HR, Jiang J,
            Watt AT, Chun S, Katz M, Qiu J, Sun Y, Ling SC, Zhu Q, Polymenidou
            M, Drenner K, Artates JW, McAlonis-Downes M, Markmiller S, Hutt KR,
            Pizzo DP, Cady J, Harms MB, Baloh RH, Vandenberg SR, Yeo GW, Fu XD,
            Bennett CF, Cleveland DW and Ravits J.
  TITLE     Targeted degradation of sense and antisense C9orf72 RNA foci as
            therapy for ALS and frontotemporal degeneration
  JOURNAL   Proc Natl Acad Sci U S A 110 (47), E4530-E4539 (2013)
   PUBMED   24170860
REFERENCE   10 (residues 1 to 317)
  AUTHORS   Panda SK, Wefers B, Ortiz O, Floss T, Schmid B, Haass C, Wurst W
            and Kuhn R.
  TITLE     Highly efficient targeted mutagenesis in mice using TALENs
  JOURNAL   Genetics 195 (3), 703-713 (2013)
   PUBMED   23979585
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL831776.3, AK014175.1 and BQ177018.1.
            
            On May 4, 2018 this sequence version replaced NP_082742.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK014175.1, BY713146.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849381,
                                           SAMN01164138 [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..317
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 17.13 cM"
     Protein         1..317
                     /product="guanine nucleotide exchange factor C9orf72
                     homolog isoform 2"
                     /note="protein C9orf72 homolog; guanine nucleotide
                     exchange C9orf72 homolog; guanine nucleotide exchange
                     factor C9orf72 homolog"
                     /calculated_mol_wt=35759
     Region          <12..160
                     /region_name="C9orf72-like"
                     /note="C9orf72-like protein family; pfam15019"
                     /db_xref="CDD:434396"
     CDS             1..317
                     /gene="C9orf72"
                     /gene_synonym="3110043O21Rik; Dennd9"
                     /coded_by="NM_028466.2:98..1051"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS89726.1"
                     /db_xref="GeneID:73205"
                     /db_xref="MGI:MGI:1920455"
ORIGIN      
        1 medqgqsiip mltgevipvm ellasmkshs vpedidiadt vlndddigds chegfllnai
       61 sshlqtcgcs vvvgssaekv nkivrtlclf ltpaerkcsr lceaessfky esglfvqgll
      121 kdatgsfvlp frqvmyapyp tthidvdvnt vkqmppcheh iynqrrymrs eltafwrats
      181 eedmaqdtii ytdesftpdl nifqdvlhrd tlvkafldqv fhlkpglslr stflaqflli
      241 lhrkaltlik yieddtqkgk kpfkslrnlk idldltaegd lniimalaek ikpglhsfif
      301 grpfytsvqe rdvlmtf
//
LOCUS       NP_444346                364 aa            linear   ROD 09-OCT-2023
DEFINITION  protein Wnt-16 precursor [Mus musculus].
ACCESSION   NP_444346
VERSION     NP_444346.3
DBSOURCE    REFSEQ: accession NM_053116.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 364)
  AUTHORS   Wan X, Zhao S, Dai Y, Zhang J, Shen Y, Gong L and Le Q.
  TITLE     WNT16b promotes the proliferation and self-renewal of human limbal
            epithelial stem/progenitor cells via activating the
            calcium/calcineurin A/NFATC2 pathway
  JOURNAL   Cell Prolif 56 (10), e13460 (2023)
   PUBMED   36974338
  REMARK    GeneRIF: WNT16b promotes the proliferation and self-renewal of
            human limbal epithelial stem/progenitor cells via activating the
            calcium/calcineurin A/NFATC2 pathway.
REFERENCE   2  (residues 1 to 364)
  AUTHORS   Cai S, Si N, Wang Y and Yin N.
  TITLE     Transcriptomic analysis of the upper lip and primary palate
            development in mice
  JOURNAL   Front Genet 13, 1039850 (2023)
   PUBMED   36685938
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 364)
  AUTHORS   Simonson L, Oldham E and Chang H.
  TITLE     Overactive Wnt5a signaling disrupts hair follicle polarity during
            mouse skin development
  JOURNAL   Development 149 (22) (2022)
   PUBMED   36305473
REFERENCE   4  (residues 1 to 364)
  AUTHORS   Tornqvist AE, Nilsson KH, Li L, Ohlsson C and Moverare-Skrtic S.
  TITLE     Induced inactivation of Wnt16 in young adult mice has no impact on
            osteoarthritis development
  JOURNAL   PLoS One 17 (11), e0277495 (2022)
   PUBMED   36367882
  REMARK    GeneRIF: Induced inactivation of Wnt16 in young adult mice has no
            impact on osteoarthritis development.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 364)
  AUTHORS   Murphy P, Armit C, Hill B, Venkataraman S, Frankel P, Baldock RA
            and Davidson DR.
  TITLE     Integrated analysis of Wnt signalling system component gene
            expression
  JOURNAL   Development 149 (16) (2022)
   PUBMED   35831952
REFERENCE   6  (residues 1 to 364)
  AUTHORS   Chu EY, Hens J, Andl T, Kairo A, Yamaguchi TP, Brisken C, Glick A,
            Wysolmerski JJ and Millar SE.
  TITLE     Canonical WNT signaling promotes mammary placode development and is
            essential for initiation of mammary gland morphogenesis
  JOURNAL   Development 131 (19), 4819-4829 (2004)
   PUBMED   15342465
REFERENCE   7  (residues 1 to 364)
  AUTHORS   Heller RS, Dichmann DS, Jensen J, Miller C, Wong G, Madsen OD and
            Serup P.
  TITLE     Expression patterns of Wnts, Frizzleds, sFRPs, and misexpression in
            transgenic mice suggesting a role for Wnts in pancreas and foregut
            pattern formation
  JOURNAL   Dev Dyn 225 (3), 260-270 (2002)
   PUBMED   12412008
REFERENCE   8  (residues 1 to 364)
  AUTHORS   Weidenfeld J, Shu W, Zhang L, Millar SE and Morrisey EE.
  TITLE     The WNT7b promoter is regulated by TTF-1, GATA6, and Foxa2 in lung
            epithelium
  JOURNAL   J Biol Chem 277 (23), 21061-21070 (2002)
   PUBMED   11914369
REFERENCE   9  (residues 1 to 364)
  AUTHORS   Reddy S, Andl T, Bagasra A, Lu MM, Epstein DJ, Morrisey EE and
            Millar SE.
  TITLE     Characterization of Wnt gene expression in developing and postnatal
            hair follicles and identification of Wnt5a as a target of Sonic
            hedgehog in hair follicle morphogenesis
  JOURNAL   Mech Dev 107 (1-2), 69-82 (2001)
   PUBMED   11520664
REFERENCE   10 (residues 1 to 364)
  AUTHORS   McWhirter JR, Neuteboom ST, Wancewicz EV, Monia BP, Downing JR and
            Murre C.
  TITLE     Oncogenic homeodomain transcription factor E2A-Pbx1 activates a
            novel WNT gene in pre-B acute lymphoblastoid leukemia
  JOURNAL   Proc Natl Acad Sci U S A 96 (20), 11464-11469 (1999)
   PUBMED   10500199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK053805.1, BC115925.1 and AK054110.1.
            
            On Aug 8, 2009 this sequence version replaced NP_444346.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK054110.1, BC115811.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..364
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 9.22 cM"
     Protein         1..364
                     /product="protein Wnt-16 precursor"
                     /note="protein Wnt-16; wingless-related MMTV integration
                     site 16"
                     /calculated_mol_wt=37790
     sig_peptide     1..29
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=2956
     Region          52..364
                     /region_name="Wnt_Wnt16"
                     /note="Wnt domain found in protein Wnt-16 and similar
                     proteins; cd19344"
                     /db_xref="CDD:381718"
     Site            142
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9QYS1.2)"
     Site            188
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9QYS1.2)"
     Site            order(221..222,225..227,235,343,345,347,349)
                     /site_type="other"
                     /note="Frizzled receptor binding site [polypeptide
                     binding]"
                     /db_xref="CDD:381718"
     Site            310
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9QYS1.2)"
     CDS             1..364
                     /gene="Wnt16"
                     /gene_synonym="E130309I19Rik"
                     /coded_by="NM_053116.4:281..1375"
                     /db_xref="CCDS:CCDS19936.1"
                     /db_xref="GeneID:93735"
                     /db_xref="MGI:MGI:2136018"
ORIGIN      
        1 mdraallalp slcalwaavl sllpcgtqgn wmwlgiasfg vpeklgcadl plnsrqkelc
       61 krkpyllpsi regarlgiqe crsqfrherw ncmvatttst qlataplfgy elssgtketa
      121 fiyaimaagl vhsvtrscsa gnmtecscdt tlqnggspse gwhwggcsdd vqygmwfsrk
      181 fldlpirntt gkesrvllam nlhnneagrq avaklmsvdc rchgvsgsca vktcwktmss
      241 fekighflkd kyensiqisd ktkrkmrrre kdqrqtpilk ddllyvhksp nycvenkklg
      301 ipgtqgrecn rtsggadgcn llccgrgynt hvvrhverce ckfiwccyvr crrcesmtdv
      361 htck
//
LOCUS       NP_001390652             736 aa            linear   ROD 09-OCT-2023
DEFINITION  transcriptional repressor CTCF isoform 1 [Mus musculus].
ACCESSION   NP_001390652
VERSION     NP_001390652.1
DBSOURCE    REFSEQ: accession NM_001403723.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 736)
  AUTHORS   Hewitt SC, Gruzdev A, Willson CJ, Wu SP, Lydon JP, Galjart N and
            DeMayo FJ.
  TITLE     Chromatin architectural factor CTCF is essential for
            progesterone-dependent uterine maturation
  JOURNAL   FASEB J 37 (8), e23103 (2023)
   PUBMED   37489832
  REMARK    GeneRIF: Chromatin architectural factor CTCF is essential for
            progesterone-dependent uterine maturation.
REFERENCE   2  (residues 1 to 736)
  AUTHORS   Smits WK, Vermeulen C, Hagelaar R, Kimura S, Vroegindeweij EM,
            Buijs-Gladdines JGCAM, van de Geer E, Verstegen MJAM, Splinter E,
            van Reijmersdal SV, Buijs A, Galjart N, van Eyndhoven W, van Min M,
            Kuiper R, Kemmeren P, Mullighan CG, de Laat W and Meijerink JPP.
  TITLE     Elevated enhancer-oncogene contacts and higher oncogene expression
            levels by recurrent CTCF inactivating mutations in acute T cell
            leukemia
  JOURNAL   Cell Rep 42 (4), 112373 (2023)
   PUBMED   37060567
REFERENCE   3  (residues 1 to 736)
  AUTHORS   Wang B, Ji L and Bian Q.
  TITLE     SATB1 regulates 3D genome architecture in T cells by constraining
            chromatin interactions surrounding CTCF-binding sites
  JOURNAL   Cell Rep 42 (4), 112323 (2023)
   PUBMED   37000624
  REMARK    GeneRIF: SATB1 regulates 3D genome architecture in T cells by
            constraining chromatin interactions surrounding CTCF-binding sites.
REFERENCE   4  (residues 1 to 736)
  AUTHORS   Marina-Zarate E, Rodriguez-Ronchel A, Gomez MJ, Sanchez-Cabo F and
            Ramiro AR.
  TITLE     Low-affinity CTCF binding drives transcriptional regulation whereas
            high-affinity binding encompasses architectural functions
  JOURNAL   iScience 26 (3), 106106 (2023)
   PUBMED   36852270
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 736)
  AUTHORS   Hsieh TS, Cattoglio C, Slobodyanyuk E, Hansen AS, Darzacq X and
            Tjian R.
  TITLE     Enhancer-promoter interactions and transcription are largely
            maintained upon acute loss of CTCF, cohesin, WAPL or YY1
  JOURNAL   Nat Genet 54 (12), 1919-1932 (2022)
   PUBMED   36471071
  REMARK    GeneRIF: Enhancer-promoter interactions and transcription are
            largely maintained upon acute loss of CTCF, cohesin, WAPL or YY1.
REFERENCE   6  (residues 1 to 736)
  AUTHORS   Farrell CM, West AG and Felsenfeld G.
  TITLE     Conserved CTCF insulator elements flank the mouse and human
            beta-globin loci
  JOURNAL   Mol Cell Biol 22 (11), 3820-3831 (2002)
   PUBMED   11997516
  REMARK    GeneRIF: Conserved CTCF insulator elements flank the mouse and
            human beta-globin loci.
REFERENCE   7  (residues 1 to 736)
  AUTHORS   Burke LJ, Hollemann T, Pieler T and Renkawitz R.
  TITLE     Molecular cloning and expression of the chromatin insulator protein
            CTCF in Xenopus laevis
  JOURNAL   Mech Dev 113 (1), 95-98 (2002)
   PUBMED   11900981
REFERENCE   8  (residues 1 to 736)
  AUTHORS   Chao W, Huynh KD, Spencer RJ, Davidow LS and Lee JT.
  TITLE     CTCF, a candidate trans-acting factor for X-inactivation choice
  JOURNAL   Science 295 (5553), 345-347 (2002)
   PUBMED   11743158
  REMARK    GeneRIF: It's proposed that Tsix and CTCF together establish a
            regulatable epigenetic switch for X-inactivation.
REFERENCE   9  (residues 1 to 736)
  AUTHORS   Lutz M, Burke LJ, Barreto G, Goeman F, Greb H, Arnold R,
            Schultheiss H, Brehm A, Kouzarides T, Lobanenkov V and Renkawitz R.
  TITLE     Transcriptional repression by the insulator protein CTCF involves
            histone deacetylases
  JOURNAL   Nucleic Acids Res 28 (8), 1707-1713 (2000)
   PUBMED   10734189
REFERENCE   10 (residues 1 to 736)
  AUTHORS   Filippova GN, Fagerlie S, Klenova EM, Myers C, Dehner Y, Goodwin G,
            Neiman PE, Collins SJ and Lobanenkov VV.
  TITLE     An exceptionally conserved transcriptional repressor, CTCF, employs
            different combinations of zinc fingers to bind diverged promoter
            sequences of avian and mammalian c-myc oncogenes
  JOURNAL   Mol Cell Biol 16 (6), 2802-2813 (1996)
   PUBMED   8649389
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127419.3 and AC152826.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422600.2015337.1,
                                           SRR10662773.396646.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..736
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.04 cM"
     Protein         1..736
                     /product="transcriptional repressor CTCF isoform 1"
                     /note="transcriptional repressor CTCF; CTCFL paralog;
                     11-zinc finger protein"
                     /calculated_mol_wt=83615
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          180..211
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61164.2)"
     Region          266..289
                     /region_name="zf-H2C2_5"
                     /note="C2H2-type zinc-finger domain; pfam13909"
                     /db_xref="CDD:404746"
     Region          268..288
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(273,275,277,279..280,283..284,287,301,303,307..308,
                     311..312,315,329,331,333,335..336,339..340,346)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          280..305
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:433230"
     Site            289
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          296..316
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          309..333
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:433230"
     Site            317
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          324..347
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          351..375
                     /region_name="zf-H2C2_5"
                     /note="C2H2-type zinc-finger domain; pfam13909"
                     /db_xref="CDD:404746"
     Region          353..373
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          <366..500
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Site            374
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          381..401
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            402
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          409..426
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          439..457
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          469..489
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(474,476,478,480..481,484..485,488,502,504,508..509,
                     512..513,516,530,532,534,536..537,540..541,545)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          497..517
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          509..534
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:433230"
     Region          525..546
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          557..573
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          573..686
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61164.2)"
     Site            609
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Site            610
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Site            612
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          699..726
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61164.2)"
     CDS             1..736
                     /gene="Ctcf"
                     /coded_by="NM_001403723.1:496..2706"
                     /note="isoform 1 is encoded by transcript variant 3"
                     /db_xref="GeneID:13018"
                     /db_xref="MGI:MGI:109447"
ORIGIN      
        1 megeaveaiv eesetfikgk erktyqrrre ggqeedachl pqnqtdggev vqdvnssvqm
       61 vmmeqldptl lqmktevmeg tvapeaeaav ddtqiitlqv vnmeeqpini gelqlvqvpv
      121 pvtvpvatts veelqgayen evskeglaes epmichtlpl pegfqvvkvg angevetleq
      181 gelppqedss wqkdpdyqpp akktkktkks klryteegkd vdvsvydfee eqqegllsev
      241 naekvvgnmk ppkptkikkk gvkktfqcel csytcprrsn ldrhmkshtd erphkchlcg
      301 rafrtvtllr nhlnthtgtr phkcpdcdma fvtsgelvrh rrykhthekp fkcsmcdyas
      361 vevsklkrhi rshtgerpfq cslcsyasrd tyklkrhmrt hsgekpyecy icharftqsg
      421 tmkmhilqkh tenvakfhcp hcdtviarks dlgvhlrkqh syieqgkkcr ycdavfhery
      481 aliqhqkshk nekrfkcdqc dyacrqerhm imhkrthtge kpyacshcdk tfrqkqlldm
      541 hfkryhdpnf vpaafvcskc gktftrrntm arhadncagp dgvegengge tkkskrgrkr
      601 kmrskkedss dseenaepdl ddneeeeepa veiepepepq pqpppppqpv apapppakkr
      661 rgrppgrtnq pkqnqptaii qvedqntgai eniivevkke pdaepaegee eeaqaattda
      721 pngdltpemi lsmmdr
//
LOCUS       NP_001278105             473 aa            linear   ROD 09-OCT-2023
DEFINITION  nuclear factor of activated T-cells, cytoplasmic 2 isoform h [Mus
            musculus].
ACCESSION   NP_001278105
VERSION     NP_001278105.1
DBSOURCE    REFSEQ: accession NM_001291176.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 473)
  AUTHORS   Fu Y, Wang J, Liu C, Liao K, Gao X, Tang R, Fan B, Hong Y, Xiao N,
            Xiao C and Liu WH.
  TITLE     Glycogen synthase kinase 3 controls T-cell exhaustion by regulating
            NFAT activation
  JOURNAL   Cell Mol Immunol 20 (10), 1127-1139 (2023)
   PUBMED   37553428
  REMARK    GeneRIF: Glycogen synthase kinase 3 controls T-cell exhaustion by
            regulating NFAT activation.
REFERENCE   2  (residues 1 to 473)
  AUTHORS   Wan X, Zhao S, Dai Y, Zhang J, Shen Y, Gong L and Le Q.
  TITLE     WNT16b promotes the proliferation and self-renewal of human limbal
            epithelial stem/progenitor cells via activating the
            calcium/calcineurin A/NFATC2 pathway
  JOURNAL   Cell Prolif 56 (10), e13460 (2023)
   PUBMED   36974338
  REMARK    GeneRIF: WNT16b promotes the proliferation and self-renewal of
            human limbal epithelial stem/progenitor cells via activating the
            calcium/calcineurin A/NFATC2 pathway.
REFERENCE   3  (residues 1 to 473)
  AUTHORS   Jiang F, Guo Y, Hu L, Zhang M, Meng J, Si Y and Shi H.
  TITLE     Role of nuclear factor of activated T Cells-1 in Sepsis-induced
            behavioral deficits in mice
  JOURNAL   Brain Res 1806, 148299 (2023)
   PUBMED   36842570
REFERENCE   4  (residues 1 to 473)
  AUTHORS   Nagai J, Lin J and Boyce JA.
  TITLE     Macrophage P2Y6 Receptor Signaling Selectively Activates NFATC2 and
            Suppresses Allergic Lung Inflammation
  JOURNAL   J Immunol 209 (12), 2293-2303 (2022)
   PUBMED   36307120
  REMARK    GeneRIF: Macrophage P2Y6 Receptor Signaling Selectively Activates
            NFATC2 and Suppresses Allergic Lung Inflammation.
REFERENCE   5  (residues 1 to 473)
  AUTHORS   Zhu L, Zhou X, Gu M, Kim J, Li Y, Ko CJ, Xie X, Gao T, Cheng X and
            Sun SC.
  TITLE     Dapl1 controls NFATc2 activation to regulate CD8+ T cell exhaustion
            and responses in chronic infection and cancer
  JOURNAL   Nat Cell Biol 24 (7), 1165-1176 (2022)
   PUBMED   35773432
REFERENCE   6  (residues 1 to 473)
  AUTHORS   Vihma H, Pruunsild P and Timmusk T.
  TITLE     Alternative splicing and expression of human and mouse NFAT genes
  JOURNAL   Genomics 92 (5), 279-291 (2008)
   PUBMED   18675896
REFERENCE   7  (residues 1 to 473)
  AUTHORS   Ho SN, Thomas DJ, Timmerman LA, Li X, Francke U and Crabtree GR.
  TITLE     NFATc3, a lymphoid-specific NFATc family member that is
            calcium-regulated and exhibits distinct DNA binding specificity
  JOURNAL   J Biol Chem 270 (34), 19898-19907 (1995)
   PUBMED   7650004
REFERENCE   8  (residues 1 to 473)
  AUTHORS   Jain J, Burgeon E, Badalian TM, Hogan PG and Rao A.
  TITLE     A similar DNA-binding motif in NFAT family proteins and the Rel
            homology region
  JOURNAL   J Biol Chem 270 (8), 4138-4145 (1995)
   PUBMED   7876165
REFERENCE   9  (residues 1 to 473)
  AUTHORS   Li X, Ho SN, Luna J, Giacalone J, Thomas DJ, Timmerman LA, Crabtree
            GR and Francke U.
  TITLE     Cloning and chromosomal localization of the human and murine genes
            for the T-cell transcription factors NFATc and NFATp
  JOURNAL   Cytogenet Cell Genet 68 (3-4), 185-191 (1995)
   PUBMED   7842733
REFERENCE   10 (residues 1 to 473)
  AUTHORS   Ho AM, Jain J, Rao A and Hogan PG.
  TITLE     Expression of the transcription factor NFATp in a neuronal cell
            line and in the murine nervous system
  JOURNAL   J Biol Chem 269 (45), 28181-28186 (1994)
   PUBMED   7961754
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK135414.1, EU887586.1 and BP757417.1.
            
            Transcript Variant: This variant (13, also known as IB-deltaII-Xa)
            contains alternate 5' and 3' exon structure, and it thus differs in
            both UTRs, initiates translation at a downstream in-frame start
            codon, and differs in the 3' coding region, compared to variant 1.
            The encoded isoform (h) is shorter at at the N-terminus and has a
            distinct C-terminus, compared to isoform a. Both variants 8 and 13
            encode isoform h.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU887586.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..473
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 88.91 cM"
     Protein         1..473
                     /product="nuclear factor of activated T-cells, cytoplasmic
                     2 isoform h"
                     /note="nuclear factor of activated T-cells, cytoplasmic 2;
                     NFAT pre-existing subunit; T-cell transcription factor
                     NFAT1"
                     /calculated_mol_wt=52180
     Region          <1..124
                     /region_name="RHD-n"
                     /note="N-terminal sub-domain of the Rel homology domain
                     (RHD); cl08275"
                     /db_xref="CDD:447596"
     Region          129..229
                     /region_name="IPT_NFAT"
                     /note="IPT domain of the NFAT family of transcription
                     factors. NFAT transcription complexes are a target of
                     calcineurin, a calcium dependent phosphatase, and activate
                     genes mainly involved in cell-cell-interaction; cd01178"
                     /db_xref="CDD:238583"
     Site            order(153,217)
                     /site_type="DNA binding"
                     /note="DNA binding sites [nucleotide binding]"
                     /db_xref="CDD:238583"
     CDS             1..473
                     /gene="Nfatc2"
                     /gene_synonym="NF-ATc2; NF-ATp; NFAT1; NFAT1-D; Nfatp"
                     /coded_by="NM_001291176.1:489..1910"
                     /note="isoform h is encoded by transcript variant 13"
                     /db_xref="GeneID:18019"
                     /db_xref="MGI:MGI:102463"
ORIGIN      
        1 menkplglqi figtaderil kphafyqvhr itgktvttts yekivgntkv leiplepknn
       61 mratidcagi lklrnadiel rkgetdigrk ntrvrlvfrv hvpepsgriv slqaasnpie
      121 csqrsahelp mverqdmdsc lvyggqqmil tgqnftaesk vvfmekttdg qqiwemeatv
      181 dkdksqpnml fveipeyrnk hirvpvkvnf yvingkrkrs qpqhftyhpv paiktepsde
      241 yepslicspa hgglgsqpyy pqhpmlaesp sclvatmapc qqfrsglssp daryqqqspa
      301 aalyqrsksl spgllgyqqp sllaaplgla dahrsvlvha gsqgqgqgst lphtssasqq
      361 aspvihyspt nqqlrggghq efqhimycen fgpssarpgp ppinqgqrls pgayptviqq
      421 qtapsqraak ngpsdqkeal ptgvtvkqeq nldqtyldde lidthlswiq nil
//
LOCUS       NP_001341978             509 aa            linear   ROD 09-OCT-2023
DEFINITION  activin receptor type-1 precursor [Mus musculus].
ACCESSION   NP_001341978 XP_017170494
VERSION     NP_001341978.1
DBSOURCE    REFSEQ: accession NM_001355049.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 509)
  AUTHORS   Yang YS, Lin C, Ma H, Xie J, Kaplan FS, Gao G and Shim JH.
  TITLE     AAV-Mediated Targeting of the Activin A-ACVR1R206H Signaling in
            Fibrodysplasia Ossificans Progressiva
  JOURNAL   Biomolecules 13 (9), 1364 (2023)
   PUBMED   37759764
  REMARK    GeneRIF: AAV-Mediated Targeting of the Activin A-ACVR1[R206H]
            Signaling in Fibrodysplasia Ossificans Progressiva.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 509)
  AUTHORS   Yamaguchi H, Shen J, Little DR, Li M, Sozen S, Suzuki K, Mishina Y
            and Komatsu Y.
  TITLE     Enhanced BMP signaling through ALK2 attenuates keratinocyte
            differentiation
  JOURNAL   Biochem Biophys Res Commun 629, 101-105 (2022)
   PUBMED   36116371
  REMARK    GeneRIF: Enhanced BMP signaling through ALK2 attenuates
            keratinocyte differentiation.
REFERENCE   3  (residues 1 to 509)
  AUTHORS   Yamamoto M, Stoessel SJ, Yamamoto S and Goldhamer DJ.
  TITLE     Overexpression of Wild-Type ACVR1 in Fibrodysplasia Ossificans
            Progressiva Mice Rescues Perinatal Lethality and Inhibits
            Heterotopic Ossification
  JOURNAL   J Bone Miner Res 37 (11), 2077-2093 (2022)
   PUBMED   35637634
  REMARK    GeneRIF: Overexpression of Wild-Type ACVR1 in Fibrodysplasia
            Ossificans Progressiva Mice Rescues Perinatal Lethality and
            Inhibits Heterotopic Ossification.
REFERENCE   4  (residues 1 to 509)
  AUTHORS   Lees-Shepard JB, Stoessel SJ, Chandler JT, Bouchard K, Bento P,
            Apuzzo LN, Devarakonda PM, Hunter JW and Goldhamer DJ.
  TITLE     An anti-ACVR1 antibody exacerbates heterotopic ossification by
            fibro-adipogenic progenitors in fibrodysplasia ossificans
            progressiva mice
  JOURNAL   J Clin Invest 132 (12) (2022)
   PUBMED   35503416
REFERENCE   5  (residues 1 to 509)
  AUTHORS   Chen HY, Hu Y, Xu XB, Zhou YA, Li NS, He C, Xie C, Lu NH and Zhu Y.
  TITLE     Upregulation of oncogene Activin A receptor type I by Helicobacter
            pylori infection promotes gastric intestinal metaplasia via
            regulating CDX2
  JOURNAL   Helicobacter 26 (6), e12849 (2021)
   PUBMED   34490965
  REMARK    GeneRIF: Upregulation of oncogene Activin A receptor type I by
            Helicobacter pylori infection promotes gastric intestinal
            metaplasia via regulating CDX2.
REFERENCE   6  (residues 1 to 509)
  AUTHORS   Schmitt J, Mielke R and Schrewe H.
  TITLE     Genomic organization of a mouse type I activin receptor
  JOURNAL   Biochem Biophys Res Commun 213 (1), 211-217 (1995)
   PUBMED   7639738
REFERENCE   7  (residues 1 to 509)
  AUTHORS   Verschueren K, Dewulf N, Goumans MJ, Lonnoy O, Feijen A, Grimsby S,
            Vandi Spiegle K, ten Dijke P, Moren A, Vanscheeuwijck P, Heldin CH,
            Miyazono K, Mummery C, Van Den Eijnden-Van Raaij J and Huylebroeck
            D.
  TITLE     Expression of type I and type IB receptors for activin in
            midgestation mouse embryos suggests distinct functions in
            organogenesis
  JOURNAL   Mech Dev 52 (1), 109-123 (1995)
   PUBMED   7577669
REFERENCE   8  (residues 1 to 509)
  AUTHORS   Roelen BA, Lin HY, Knezevic V, Freund E and Mummery CL.
  TITLE     Expression of TGF-beta s and their receptors during implantation
            and organogenesis of the mouse embryo
  JOURNAL   Dev Biol 166 (2), 716-728 (1994)
   PUBMED   7813789
REFERENCE   9  (residues 1 to 509)
  AUTHORS   Nakamura T, Sugino K, Kurosawa N, Sawai M, Takio K, Eto Y, Iwashita
            S, Muramatsu M, Titani K and Sugino H.
  TITLE     Isolation and characterization of activin receptor from mouse
            embryonal carcinoma cells. Identification of its
            serine/threonine/tyrosine protein kinase activity
  JOURNAL   J Biol Chem 267 (26), 18924-18928 (1992)
   PUBMED   1326537
REFERENCE   10 (residues 1 to 509)
  AUTHORS   Mathews LS and Vale WW.
  TITLE     Expression cloning of an activin receptor, a predicted
            transmembrane serine kinase
  JOURNAL   Cell 65 (6), 973-982 (1991)
   PUBMED   1646080
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732468.10 and AL807788.9.
            
            On Sep 6, 2017 this sequence version replaced XP_017170494.1.
            
            Transcript Variant: This variant (5) differs in the 5' UTR compared
            to variant 1. All five variants encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.68366.1,
                                           SRR1660811.243143.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 33.05 cM"
     Protein         1..509
                     /product="activin receptor type-1 precursor"
                     /EC_number="2.7.11.30"
                     /note="activin receptor type-1; TSR-I; TSK-7L; activin
                     receptor type I; TGF-B superfamily receptor type I;
                     serine/threonine-protein kinase receptor R1"
                     /calculated_mol_wt=55077
     sig_peptide     1..20
                     /note="/evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (P37172.2)"
                     /calculated_mol_wt=2167
     mat_peptide     21..509
                     /product="Activin receptor type-1. /id=PRO_0000024395"
                     /note="propagated from UniProtKB/Swiss-Prot (P37172.2)"
                     /calculated_mol_wt=55077
     Region          33..103
                     /region_name="Activin_recp"
                     /note="Activin types I and II receptor domain; pfam01064"
                     /db_xref="CDD:426025"
     Site            102
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P37172.2)"
     Site            124..146
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P37172.2)"
     Region          179..206
                     /region_name="TGF_beta_GS"
                     /note="Transforming growth factor beta type I GS-motif;
                     pfam08515"
                     /db_xref="CDD:430045"
     Region          202..499
                     /region_name="STKc_ACVR1_ALK1"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     Activin Type I Receptor and Activin receptor-Like Kinase
                     1; cd14142"
                     /db_xref="CDD:271044"
     Site            order(202..203,206..207,245..246,249..250,253..254,268,
                     270)
                     /site_type="other"
                     /note="FKBP12 binding site [polypeptide binding]"
                     /db_xref="CDD:271044"
     Site            order(214..218,222,233,235,263,283..286,290,292,336,338,
                     340..341,343,354,357,377..380)
                     /site_type="active"
                     /db_xref="CDD:271044"
     Site            order(214..220,222,233,235,283..284,286,290,340..341,343,
                     354)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271044"
     Site            order(218,290,292,336,338,340,357,377..380)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:271044"
     Site            353..380
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:271044"
     Site            501
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q04771; propagated from
                     UniProtKB/Swiss-Prot (P37172.2)"
     CDS             1..509
                     /gene="Acvr1"
                     /gene_synonym="ActR-I; ActRIA; Acvr; Acvr1a; Acvrlk2;
                     Alk-2; ALK2; Alk8; D330013D15Rik; SKR1; Tsk7L"
                     /coded_by="NM_001355049.1:515..2044"
                     /db_xref="CCDS:CCDS16050.1"
                     /db_xref="GeneID:11477"
                     /db_xref="MGI:MGI:87911"
ORIGIN      
        1 mvdgvmilpv lmmmafpsps vedekpkvnq klymcvcegl scgnedhceg qqcfsslsin
       61 dgfhvyqkgc fqvyeqgkmt cktppspgqa veccqgdwcn rnitaqlptk gksfpgtqnf
      121 hlevgliils vvfavcllac ilgvalrkfk rrnqerlnpr dveygtiegl ittnvgdstl
      181 aelldhscts gsgsglpflv qrtvarqitl lecvgkgryg evwrgswqge nvavkifssr
      241 dekswfrete lyntvmlrhe nilgfiasdm tsrhsstqlw lithyhemgs lydylqlttl
      301 dtvsclrivl siasglahlh ieifgtqgks aiahrdlksk nilvkkngqc ciadlglavm
      361 hsqstnqldv gnnprvgtkr ymapevldet iqvdcfdsyk rvdiwafglv lwevarrmvs
      421 ngivedykpp fydvvpndps fedmrkvvcv dqqrpnipnr wfsdptltsl aklmkecwyq
      481 npsarltalr ikktltkidn sldklktdc
//
LOCUS       NP_001342179            1021 aa            linear   ROD 09-OCT-2023
DEFINITION  SWI/SNF-related matrix-associated actin-dependent regulator of
            chromatin subfamily A containing DEAD/H box 1 isoform 1 [Mus
            musculus].
ACCESSION   NP_001342179 XP_006505572
VERSION     NP_001342179.1
DBSOURCE    REFSEQ: accession NM_001355250.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1021)
  AUTHORS   Sachs P, Bergmaier P, Treutwein K and Mermoud JE.
  TITLE     The Conserved Chromatin Remodeler SMARCAD1 Interacts with TFIIIC
            and Architectural Proteins in Human and Mouse
  JOURNAL   Genes (Basel) 14 (9), 1793 (2023)
   PUBMED   37761933
  REMARK    GeneRIF: The Conserved Chromatin Remodeler SMARCAD1 Interacts with
            TFIIIC and Architectural Proteins in Human and Mouse.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1021)
  AUTHORS   Bedogni F and Hevner RF.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1021)
  AUTHORS   Niu Q, Wang W, Wei Z, Byeon B, Das AB, Chen BS and Wu WH.
  TITLE     Role of the ATP-dependent chromatin remodeling enzyme
            Fun30/Smarcad1 in the regulation of mRNA splicing
  JOURNAL   Biochem Biophys Res Commun 526 (2), 453-458 (2020)
   PUBMED   32234239
  REMARK    GeneRIF: Role of the ATP-dependent chromatin remodeling enzyme
            Fun30/Smarcad1 in the regulation of mRNA splicing.
REFERENCE   4  (residues 1 to 1021)
  AUTHORS   Kazakevych J, Denizot J, Liebert A, Portovedo M, Mosavie M, Jain P,
            Stellato C, Fraser C, Correa RO, Celestine M, Mattiuz R, Okkenhaug
            H, Miller JR, Vinolo MAR, Veldhoen M and Varga-Weisz P.
  TITLE     Smarcad1 mediates microbiota-induced inflammation in mouse and
            coordinates gene expression in the intestinal epithelium
  JOURNAL   Genome Biol 21 (1), 64 (2020)
   PUBMED   32160911
  REMARK    GeneRIF: Smarcad1 mediates microbiota-induced inflammation in mouse
            and coordinates gene expression in the intestinal epithelium.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1021)
  AUTHORS   Sachs P, Ding D, Bergmaier P, Lamp B, Schlagheck C, Finkernagel F,
            Nist A, Stiewe T and Mermoud JE.
  TITLE     SMARCAD1 ATPase activity is required to silence endogenous
            retroviruses in embryonic stem cells
  JOURNAL   Nat Commun 10 (1), 1335 (2019)
   PUBMED   30902974
  REMARK    GeneRIF: These findings uncover a role for the enzymatic activity
            of SMARCAD1 in cooperating with KAP1 to silence Endogenous
            retroviruses.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1021)
  AUTHORS   Ben-Arie N, McCall AE, Berkman S, Eichele G, Bellen HJ and Zoghbi
            HY.
  TITLE     Evolutionary conservation of sequence and expression of the bHLH
            protein Atonal suggests a conserved role in neurogenesis
  JOURNAL   Hum Mol Genet 5 (9), 1207-1216 (1996)
   PUBMED   8872459
REFERENCE   7  (residues 1 to 1021)
  AUTHORS   Villeneuve L, Jiang X, Turmel C, Kozak CA and Jolicoeur P.
  TITLE     Long-range mapping of Mis-2, a common provirus integration site
            identified in murine leukemia virus-induced thymomas and located
            160 kilobase pairs downstream of Myb
  JOURNAL   J Virol 67 (10), 5733-5739 (1993)
   PUBMED   8371338
REFERENCE   8  (residues 1 to 1021)
  AUTHORS   Schoor M, Schuster-Gossler K and Gossler A.
  TITLE     The Etl-1 gene encodes a nuclear protein differentially expressed
            during early mouse development
  JOURNAL   Dev Dyn 197 (3), 227-237 (1993)
   PUBMED   8219362
REFERENCE   9  (residues 1 to 1021)
  AUTHORS   Soininen R, Schoor M, Henseling U, Tepe C, Kisters-Woike B, Rossant
            J and Gossler A.
  TITLE     The mouse Enhancer trap locus 1 (Etl-1): a novel mammalian gene
            related to Drosophila and yeast transcriptional regulator genes
  JOURNAL   Mech Dev 39 (1-2), 111-123 (1992)
   PUBMED   1489724
REFERENCE   10 (residues 1 to 1021)
  AUTHORS   O'Kane CJ and Gehring WJ.
  TITLE     Detection in situ of genomic regulatory elements in Drosophila
  JOURNAL   Proc Natl Acad Sci U S A 84 (24), 9123-9127 (1987)
   PUBMED   2827169
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC138622.4 and AC143330.4.
            
            On Sep 13, 2017 this sequence version replaced XP_006505572.1.
            
            Transcript Variant: This variant (5) differs in the 5' UTR,
            compared to variant 1, and encodes isoform 1. Variants 1 and 5
            encode the same protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13948564.3258052.1,
                                           SRR17253012.4251560.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1021
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 30.11 cM"
     Protein         1..1021
                     /product="SWI/SNF-related matrix-associated
                     actin-dependent regulator of chromatin subfamily A
                     containing DEAD/H box 1 isoform 1"
                     /EC_number="3.6.4.12"
                     /note="enhancer trap locus homolog 1; ATP-dependent
                     helicase SMARCAD1; enhancer trap locus 1"
                     /calculated_mol_wt=116321
     Region          1..82
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q04692.2)"
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:Q9H4L7; propagated from
                     UniProtKB/Swiss-Prot (Q04692.2)"
     Site            54
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9H4L7; propagated from
                     UniProtKB/Swiss-Prot (Q04692.2)"
     Site            57
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H4L7; propagated from
                     UniProtKB/Swiss-Prot (Q04692.2)"
     Site            79
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H4L7; propagated from
                     UniProtKB/Swiss-Prot (Q04692.2)"
     Region          124..151
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q04692.2)"
     Site            124
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q04692.2)"
     Site            127
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q04692.2)"
     Site            132
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H4L7; propagated from
                     UniProtKB/Swiss-Prot (Q04692.2)"
     Site            144
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q04692.2)"
     Site            145
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q04692.2)"
     Site            151
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q04692.2)"
     Region          201..246
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q04692.2)"
     Site            210
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H4L7; propagated from
                     UniProtKB/Swiss-Prot (Q04692.2)"
     Site            213
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H4L7; propagated from
                     UniProtKB/Swiss-Prot (Q04692.2)"
     Site            235
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H4L7; propagated from
                     UniProtKB/Swiss-Prot (Q04692.2)"
     Site            238
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H4L7; propagated from
                     UniProtKB/Swiss-Prot (Q04692.2)"
     Site            298
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H4L7; propagated from
                     UniProtKB/Swiss-Prot (Q04692.2)"
     Region          329..366
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q04692.2)"
     Region          471..>993
                     /region_name="PLN03142"
                     /note="Probable chromatin-remodeling complex ATPase chain;
                     Provisional"
                     /db_xref="CDD:215601"
     Region          492..674
                     /region_name="DEXHc_SMARCAD1"
                     /note="DEXH-box helicase domain of SMARCAD1; cd17998"
                     /db_xref="CDD:350756"
     Site            order(519..525,558,623..624)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:350756"
     Region          623..626
                     /region_name="DEGH box"
                     /note="propagated from UniProtKB/Swiss-Prot (Q04692.2)"
     Region          716..733
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q04692.2)"
     Region          1000..1003
                     /region_name="DEAD box"
                     /note="propagated from UniProtKB/Swiss-Prot (Q04692.2)"
     CDS             1..1021
                     /gene="Smarcad1"
                     /gene_synonym="D6Pas1; etl-1; Etl1; mKIAA1122"
                     /coded_by="NM_001355250.2:176..3241"
                     /note="isoform 1 is encoded by transcript variant 5"
                     /db_xref="CCDS:CCDS20204.1"
                     /db_xref="GeneID:13990"
                     /db_xref="MGI:MGI:95453"
ORIGIN      
        1 mnlfnldrfr fekrskieea peaapqpsqa rpsspislsa eeenaegegs rantpdsdvt
       61 ektedssvpe ppdnerkasl scfqnqraiq eyidlssdte dvspncsstv qekkfskdtv
      121 iivsepsede eshdlpsvtr rndsseledl seledlkdak lqtlkelfpq rsdsdllkli
      181 eststmdgai aaallmfgda gggprkrkls ssseeddvnd dqsvkqprgd rgeesnesae
      241 assnwekqes ivlklqkefp nfdkqelrev lkehewmyte aleslkvfae dqdvqcasqs
      301 evtngkevar nqnysknatk ikmkqkisvk pqngfnkkrk knvfnpkkav edseydsgsd
      361 agssldedys sceevmedgy kgkilhflqv ssiaeltlip kcsqkkaqki telrpfnnwe
      421 alftkmskin glsedliwnc ktviqerdvv irlmnkcedi snkltkqvtm ltgngggwnr
      481 eqpsllnqsl slkpyqkvgl nwlalvhkhg lngilademg lgktiqaiaf laylfqegnk
      541 gphlivvpas tidnwlrevn lwcpslnvlc yygsqeerkq irfnihnkye dynvivttyn
      601 caisssddrs lfrrlklnya ifdeghmlkn mgsiryqhlm tinarnrlll tgtpvqnnll
      661 elmsllnfvm phmfssstse irrmfssktk padeqsiyek eriahakqii kpfilrrvke
      721 evlkllppkk drielcamse kqeqlysglf nrlkksinnl ekntemcnvm mqlrkmanhp
      781 llhrqyytpe klkemsqlml kepthceanp dlifedmevm tdfelhvlck qyqhinsyql
      841 dmdlildsgk fralgcilse lkqkgdrvvl fsqftmmldi levllkhhqh rylrldgktq
      901 iserihlide fntdmdifvf llstkagglg inltsanvvi lhdidcnpyn dkqaedrchr
      961 vgqtkevlvi klisqgtiee smlkinqqkl kleqdmttvd eadegsmpad iatllktsmg
     1021 l
//
LOCUS       NP_001348430             147 aa            linear   ROD 09-OCT-2023
DEFINITION  allograft inflammatory factor 1 isoform a [Mus musculus].
ACCESSION   NP_001348430 XP_006523567
VERSION     NP_001348430.1
DBSOURCE    REFSEQ: accession NM_001361501.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 147)
  AUTHORS   Altounian M, Bellon A and Mann F.
  TITLE     Neuronal miR-17-5p contributes to interhemispheric cortical
            connectivity defects induced by prenatal alcohol exposure
  JOURNAL   Cell Rep 42 (9), 113020 (2023)
   PUBMED   37610874
REFERENCE   2  (residues 1 to 147)
  AUTHORS   Rodriguez-Lopez A, Torres-Paniagua AM, Acero G, Diaz G and
            Gevorkian G.
  TITLE     Increased TSPO expression, pyroglutamate-modified amyloid beta
            (AbetaN3(pE)) accumulation and transient clustering of microglia in
            the thalamus of Tg-SwDI mice
  JOURNAL   J Neuroimmunol 382, 578150 (2023)
   PUBMED   37467699
  REMARK    GeneRIF: Increased TSPO expression, pyroglutamate-modified amyloid
            beta (AbetaN3(pE)) accumulation and transient clustering of
            microglia in the thalamus of Tg-SwDI mice.
REFERENCE   3  (residues 1 to 147)
  AUTHORS   Cao B, Xia Y, Cai Z, Wang Z, Tang C and Song Y.
  TITLE     Construction of a Brain-specific SLC23A2 Gene Knockout Mice Model
  JOURNAL   Neuroscience 524, 137-148 (2023)
   PUBMED   37330196
REFERENCE   4  (residues 1 to 147)
  AUTHORS   Meng H, Zhao Y, Li Y, Fan H, Yi X, Meng X, Wang P, Fu F, Wu S and
            Wang Y.
  TITLE     Evidence for developmental vascular-associated necroptosis and its
            contribution to venous-lymphatic endothelial differentiation
  JOURNAL   Front Cell Dev Biol 11, 1229788 (2023)
   PUBMED   37576598
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 147)
  AUTHORS   Waldhauser V, Baroti T, Frob F and Wegner M.
  TITLE     PBAF Subunit Pbrm1 Selectively Influences the Transition from
            Progenitors to Pre-Myelinating Cells during Oligodendrocyte
            Development
  JOURNAL   Cells 12 (12), 1556 (2023)
   PUBMED   37371026
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 147)
  AUTHORS   Sasaki Y, Ohsawa K, Kanazawa H, Kohsaka S and Imai Y.
  TITLE     Iba1 is an actin-cross-linking protein in macrophages/microglia
  JOURNAL   Biochem Biophys Res Commun 286 (2), 292-297 (2001)
   PUBMED   11500035
REFERENCE   7  (residues 1 to 147)
  AUTHORS   Ohsawa K, Imai Y, Kanazawa H, Sasaki Y and Kohsaka S.
  TITLE     Involvement of Iba1 in membrane ruffling and phagocytosis of
            macrophages/microglia
  JOURNAL   J Cell Sci 113 (Pt 17), 3073-3084 (2000)
   PUBMED   10934045
REFERENCE   8  (residues 1 to 147)
  AUTHORS   Allcock RJ, Martin AM and Price P.
  TITLE     The mouse as a model for the effects of MHC genes on human disease
  JOURNAL   Immunol Today 21 (7), 328-332 (2000)
   PUBMED   10871872
  REMARK    Review article
REFERENCE   9  (residues 1 to 147)
  AUTHORS   Handel-Fernandez ME, Kurimoto I, Streilein JW and Vincek V.
  TITLE     Genetic mapping and physical cloning of UVB susceptibility region
            in mice
  JOURNAL   J Invest Dermatol 113 (2), 224-229 (1999)
   PUBMED   10469308
REFERENCE   10 (residues 1 to 147)
  AUTHORS   Lund T, Shaikh S, Kendall E, Campbell RD, Hattori M, Makino S and
            Cooke A.
  TITLE     RFLP analysis of the MHC class III region defines unique haplotypes
            for the non-obese diabetic, cataract Shionogi and the non-obese
            non-diabetic mouse strains
  JOURNAL   Diabetologia 36 (8), 727-733 (1993)
   PUBMED   8104833
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CR974444.18.
            
            On Mar 28, 2018 this sequence version replaced XP_006523567.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a). Variants 1 and 2
            both encode the same isoform (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189685.275043.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..147
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.59 cM"
     Protein         1..147
                     /product="allograft inflammatory factor 1 isoform a"
                     /note="testis specific; ionized calcium binding adapter
                     molecule 1"
                     /calculated_mol_wt=16779
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylserine.
                     /evidence=ECO:0000250|UniProtKB:P81076; propagated from
                     UniProtKB/Swiss-Prot (O70200.1)"
     Site            11
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P55008; propagated from
                     UniProtKB/Swiss-Prot (O70200.1)"
     Region          <48..113
                     /region_name="PTZ00184"
                     /note="calmodulin; Provisional"
                     /db_xref="CDD:185504"
     Region          128..147
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O70200.1)"
     CDS             1..147
                     /gene="Aif1"
                     /gene_synonym="AIF-1; D17H6S50E; G1; Iba1"
                     /coded_by="NM_001361501.2:318..761"
                     /note="isoform a is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS28689.1"
                     /db_xref="GeneID:11629"
                     /db_xref="MGI:MGI:1343098"
ORIGIN      
        1 msqsrdlqgg kafgllkaqq eerleginkq flddpkysnd edlpskleaf kvkymefdln
       61 gngdidimsl krmleklgvp kthlelkrli revssgseet fsysdflrmm lgkrsailrm
      121 ilmyeeknke hkrptgppak kaiselp
//
LOCUS       NP_001300849             810 aa            linear   ROD 09-OCT-2023
DEFINITION  hypoxia-inducible factor 1-alpha isoform 3 [Mus musculus].
ACCESSION   NP_001300849 XP_011242299
VERSION     NP_001300849.1
DBSOURCE    REFSEQ: accession NM_001313920.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 810)
  AUTHORS   Xu R, Shen S, Wang D, Ye J, Song S, Wang Z and Yue Z.
  TITLE     The role of HIF-1alpha-mediated autophagy in ionizing
            radiation-induced testicular injury
  JOURNAL   J Mol Histol 54 (5), 439-451 (2023)
   PUBMED   37728670
  REMARK    GeneRIF: The role of HIF-1alpha-mediated autophagy in ionizing
            radiation-induced testicular injury.
REFERENCE   2  (residues 1 to 810)
  AUTHORS   Yang Z, Su W, Wei X, Qu S, Zhao D, Zhou J, Wang Y, Guan Q, Qin C,
            Xiang J, Zen K and Yao B.
  TITLE     HIF-1alpha drives resistance to ferroptosis in solid tumors by
            promoting lactate production and activating SLC1A1
  JOURNAL   Cell Rep 42 (8), 112945 (2023)
   PUBMED   37542723
  REMARK    GeneRIF: HIF-1alpha drives resistance to ferroptosis in solid
            tumors by promoting lactate production and activating SLC1A1.
REFERENCE   3  (residues 1 to 810)
  AUTHORS   Dery KJ, Kojima H, Kageyama S, Kadono K, Hirao H, Cheng B, Zhai Y,
            Farmer DG, Kaldas FM, Yuan X, Eltzschig HK and Kupiec-Weglinski JW.
  TITLE     Alternative splicing of CEACAM1 by hypoxia-inducible factor-1alpha
            enhances tolerance to hepatic ischemia in mice and humans
  JOURNAL   Sci Transl Med 15 (707), eadf2059 (2023)
   PUBMED   37531413
  REMARK    GeneRIF: Alternative splicing of CEACAM1 by hypoxia-inducible
            factor-1alpha enhances tolerance to hepatic ischemia in mice and
            humans.
REFERENCE   4  (residues 1 to 810)
  AUTHORS   Guo Z, Yu X, Zhao S, Zhong X, Huang D, Feng R, Li P, Fang Z, Hu Y,
            Zhang Z, Abdurahman M, Huang L, Zhao Y, Wang X, Ge J and Li H.
  TITLE     SIRT6 deficiency in endothelial cells exacerbates oxidative stress
            by enhancing HIF1alpha accumulation and H3K9 acetylation at the
            Ero1alpha promoter
  JOURNAL   Clin Transl Med 13 (8), e1377 (2023)
   PUBMED   37598403
  REMARK    GeneRIF: SIRT6 deficiency in endothelial cells exacerbates
            oxidative stress by enhancing HIF1alpha accumulation and H3K9
            acetylation at the Ero1alpha promoter.
REFERENCE   5  (residues 1 to 810)
  AUTHORS   Zhang G, Liu B, Yang Y, Xie S, Chen L, Luo H, Zhong J, Wei Y, Guo
            F, Gan J, Zhu F, Xu L, Li Q, Shen Y, Zhang H, Liu Y, Li R, Deng H
            and Yang H.
  TITLE     Mitochondrial UQCC3 controls embryonic and tumor angiogenesis by
            regulating VEGF expression
  JOURNAL   iScience 26 (8), 107370 (2023)
   PUBMED   37539028
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 810)
  AUTHORS   Li H, Ko HP and Whitlock JP.
  TITLE     Induction of phosphoglycerate kinase 1 gene expression by hypoxia.
            Roles of Arnt and HIF1alpha
  JOURNAL   J Biol Chem 271 (35), 21262-21267 (1996)
   PUBMED   8702901
REFERENCE   7  (residues 1 to 810)
  AUTHORS   Wood SM, Gleadle JM, Pugh CW, Hankinson O and Ratcliffe PJ.
  TITLE     The role of the aryl hydrocarbon receptor nuclear translocator
            (ARNT) in hypoxic induction of gene expression. Studies in
            ARNT-deficient cells
  JOURNAL   J Biol Chem 271 (25), 15117-15123 (1996)
   PUBMED   8662957
REFERENCE   8  (residues 1 to 810)
  AUTHORS   Semenza GL, Rue EA, Iyer NV, Pang MG and Kearns WG.
  TITLE     Assignment of the hypoxia-inducible factor 1alpha gene to a region
            of conserved synteny on mouse chromosome 12 and human chromosome
            14q
  JOURNAL   Genomics 34 (3), 437-439 (1996)
   PUBMED   8786149
REFERENCE   9  (residues 1 to 810)
  AUTHORS   Wenger RH, Rolfs A, Marti HH, Guenet JL and Gassmann M.
  TITLE     Nucleotide sequence, chromosomal assignment and mRNA expression of
            mouse hypoxia-inducible factor-1 alpha
  JOURNAL   Biochem Biophys Res Commun 223 (1), 54-59 (1996)
   PUBMED   8660378
REFERENCE   10 (residues 1 to 810)
  AUTHORS   Obara N and Takeda M.
  TITLE     Expression of neural cell adhesion molecule (NCAM) during the first
            molar development in the mouse
  JOURNAL   Anat Embryol (Berl) 187 (3), 209-219 (1993)
   PUBMED   8470821
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124712.5.
            
            On Sep 11, 2015 this sequence version replaced XP_011242299.1.
            
            Summary: This gene encodes the alpha subunit which, along with the
            beta subunit, forms a heterodimeric transcription factor that
            regulates the cellular and developmental response to reduced oxygen
            tension. The transcription factor has been shown to regulate genes
            involved in several biological processes, including erythropoiesis
            and angiogenesis which aid in increased delivery of oxygen to
            hypoxic regions. The transcription factor also plays a role in the
            induction of genes involved in cell proliferation and survival,
            energy metabolism, apoptosis, and glucose and iron metabolism.
            Alternative splicing results in multiple transcript variants
            encoding different isoforms. [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (3) has an alternate 5' structure,
            which results in the use of a downstream start codon, and uses an
            alternate in-frame splice site in the 3' coding region compared to
            variant 1. The encoded isoform (3) has a shorter N-terminus
            compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X95580.1, SRR17253013.247521.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..810
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 31.99 cM"
     Protein         1..810
                     /product="hypoxia-inducible factor 1-alpha isoform 3"
                     /note="hypoxia-inducible factor 1-alpha; ARNT-interacting
                     protein"
                     /calculated_mol_wt=90484
     Region          1..71
                     /region_name="bHLH-PAS_HIF1a_PASD8"
                     /note="basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS)
                     domain found in hypoxia-inducible factor 1-alpha (HIF1a)
                     and similar proteins; cd19727"
                     /db_xref="CDD:381570"
     Site            order(6..7,9..11,14..15,17..18,43..44)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381570"
     Site            order(20..21,23..24,27..28,31..32,43..45,48..49,52,55..56,
                     59)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:381570"
     Region          81..136
                     /region_name="PAS"
                     /note="PAS domain; smart00091"
                     /db_xref="CDD:214512"
     Region          242..327
                     /region_name="PAS_3"
                     /note="PAS fold; pfam08447"
                     /db_xref="CDD:369881"
     Site            order(243,247,253,266..269,295,300)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:238075"
     Site            order(263,267,275,278..279,307,309)
                     /site_type="other"
                     /note="heme pocket [chemical binding]"
                     /db_xref="CDD:238075"
     Region          541..567
                     /region_name="HIF-1"
                     /note="Hypoxia-inducible factor-1; pfam11413"
                     /db_xref="CDD:402842"
     Region          774..809
                     /region_name="HIF-1a_CTAD"
                     /note="HIF-1 alpha C terminal transactivation domain;
                     pfam08778"
                     /db_xref="CDD:400914"
     CDS             1..810
                     /gene="Hif1a"
                     /gene_synonym="bHLHe78; HIF-1-alpha; HIF1-alpha;
                     HIF1alpha; MOP1"
                     /coded_by="NM_001313920.2:89..2521"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS83968.1"
                     /db_xref="GeneID:15251"
                     /db_xref="MGI:MGI:106918"
ORIGIN      
        1 msserrkeks rdaarsrrsk esevfyelah qlplphnvss hldkasvmrl tisylrvrkl
       61 ldaggldsed emkaqmdcfy lkaldgfvmv ltddgdmvyi sdnvnkymgl tqfeltghsv
      121 fdfthpcdhe emremlthrn gpvrkgkeln tqrsfflrmk ctltsrgrtm niksatwkvl
      181 hctghihvyd tnsnqpqcgy kkppmtclvl icepiphpsn ieipldsktf lsrhsldmkf
      241 sycderitel mgyepeellg rsiyeyyhal dsdhltkthh dmftkgqvtt gqyrmlakrg
      301 gyvwvetqat viyntknsqp qcivcvnyvv sgiiqhdlif slqqtesvlk pvessdmkmt
      361 qlftkvesed tsclfdklkk epdaltllap aagdtiisld fgsddteted qqledvplyn
      421 dvmfpssnek lninlamspl pssetpkplr ssadpalnqe valklesspe slglsftmpq
      481 iqdqpaspsd gstrqsspep nspseycfdv dsdmvnvfkl elveklfaed teaknpfstq
      541 dtdldlemla pyipmdddfq lrsfdqlspl esnspsppsm stvtgfqqtq lqkptitata
      601 tttattdesk tetkdnkedi kiliaspsst qvpqetttak asaysgthsr taspdragkr
      661 vieqtdkahp rslnlsatln qrntvpeeel npktiasqna qrkrkmehdg slfqaagigt
      721 llqqpgdcap tmslswkrvk gfisseqngt eqktiilips dlacrllgqs mdesglpqlt
      781 sydcevnapi qgsrnllqge ellraldqvn
//
LOCUS       NP_001349229             504 aa            linear   ROD 09-OCT-2023
DEFINITION  CUGBP Elav-like family member 4 isoform 24 [Mus musculus].
ACCESSION   NP_001349229
VERSION     NP_001349229.1
DBSOURCE    REFSEQ: accession NM_001362300.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 504)
  AUTHORS   Salamon I, Park Y, Miskic T, Kopic J, Matteson P, Page NF, Roque A,
            McAuliffe GW, Favate J, Garcia-Forn M, Shah P, Judas M, Millonig
            JH, Kostovic I, De Rubeis S, Hart RP, Krsnik Z and Rasin MR.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    GeneRIF: Celf4 controls mRNA translation underlying synaptic
            development in the prenatal mammalian neocortex.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 504)
  AUTHORS   Shen Y, Zhang C, Xiao K, Liu D and Xie G.
  TITLE     CELF4 regulates spine formation and depression-like behaviors of
            mice
  JOURNAL   Biochem Biophys Res Commun 605, 39-44 (2022)
   PUBMED   35306363
  REMARK    GeneRIF: CELF4 regulates spine formation and depression-like
            behaviors of mice.
REFERENCE   3  (residues 1 to 504)
  AUTHORS   Moreau MX, Saillour Y, Cwetsch AW, Pierani A and Causeret F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   4  (residues 1 to 504)
  AUTHORS   Li C, Li X, Bi Z, Sugino K, Wang G, Zhu T and Liu Z.
  TITLE     Comprehensive transcriptome analysis of cochlear spiral ganglion
            neurons at multiple ages
  JOURNAL   Elife 9, e50491 (2020)
   PUBMED   31913118
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 504)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 504)
  AUTHORS   Ladd AN, Taffet G, Hartley C, Kearney DL and Cooper TA.
  TITLE     Cardiac tissue-specific repression of CELF activity disrupts
            alternative splicing and causes cardiomyopathy
  JOURNAL   Mol Cell Biol 25 (14), 6267-6278 (2005)
   PUBMED   15988035
  REMARK    GeneRIF: CELF protein activity is required for normal alternative
            splicing in the heart in vivo and normal CELF-mediated alternative
            splicing regulation is in turn required for normal cardiac
            function.
REFERENCE   7  (residues 1 to 504)
  AUTHORS   Meins M, Schlickum S, Wilhelm C, Missbach J, Yadav S, Glaser B,
            Grzmil M, Burfeind P and Laccone F.
  TITLE     Identification and characterization of murine Brunol4, a new member
            of the elav/bruno family
  JOURNAL   Cytogenet Genome Res 97 (3-4), 254-260 (2002)
   PUBMED   12438720
  REMARK    GeneRIF: cloning and characterization
REFERENCE   8  (residues 1 to 504)
  AUTHORS   Ladd AN, Charlet N and Cooper TA.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   9  (residues 1 to 504)
  AUTHORS   Good PJ, Chen Q, Warner SJ and Herring DC.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
REFERENCE   10 (residues 1 to 504)
  AUTHORS   Yulug IG, Egan SE, See CG and Fisher EM.
  TITLE     Mapping GRB2, a signal transduction gene in the human and the mouse
  JOURNAL   Genomics 22 (2), 313-318 (1994)
   PUBMED   7806216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121094.8 and AC144938.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164131,
                              SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 13.92 cM"
     Protein         1..504
                     /product="CUGBP Elav-like family member 4 isoform 24"
                     /note="CUG-BP- and ETR-3-like factor 4; bruno-like protein
                     4; RNA-binding protein BRUNOL-4; bruno-like 4, RNA binding
                     protein"
                     /calculated_mol_wt=53765
     Region          49..135
                     /region_name="RRM1_CELF3_4_5_6"
                     /note="RNA recognition motif 1 (RRM1) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12632"
                     /db_xref="CDD:410041"
     Site            order(55,57,59..60,63,82,84,86,95..97,99,129,131)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410041"
     Region          150..230
                     /region_name="RRM2_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12635"
                     /db_xref="CDD:410043"
     Site            order(152,154,156..157,160,179,181,183,191..193,195,225,
                     227)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410043"
     Region          415..493
                     /region_name="RRM3_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12639"
                     /db_xref="CDD:241083"
     CDS             1..504
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /coded_by="NM_001362300.1:531..2045"
                     /note="isoform 24 is encoded by transcript variant 29"
                     /db_xref="GeneID:108013"
                     /db_xref="MGI:MGI:1932407"
ORIGIN      
        1 myikmatlan gqadnaslst nglgsspgsa ghmnglshsp gnpstipmkd hdaiklfigq
       61 iprnldekdl kplfeefgki yeltvlkdrf tgmhkgcafl tyceresalk aqsalheqkt
      121 lpgmnrpiqv kpadsesrgg ssclrqppsh rklfvgmlnk qqseddvrrl feafgnieec
      181 tilrgpdgns kgcafvkyss haeaqaaina lhgsqtmpga ssslvvkfad tdkertmrrm
      241 qqmagqmgmf npmaipfgay gayaqamqqq aalmasvaqg gylnpmaafa aaqmqqmaal
      301 nmnglaaapm tptsggstpp gitapavpsi pspigvngft glppqangqp aaeavfangi
      361 hpypaqspta adplqqayag vqqyagpaay paaygqisqa fpqpppmipq qqregpegcn
      421 lliyhlpqef gdaelmqmfl pfgnvisskv fvdratnqsk cfgfvsfdnp asaqtaiqam
      481 ngfqigmkrl kvqlkrpkda nrpy
//
LOCUS       NP_001139766             495 aa            linear   ROD 09-OCT-2023
DEFINITION  CUGBP Elav-like family member 4 isoform 29 [Mus musculus].
ACCESSION   NP_001139766
VERSION     NP_001139766.1
DBSOURCE    REFSEQ: accession NM_001146294.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 495)
  AUTHORS   Salamon I, Park Y, Miskic T, Kopic J, Matteson P, Page NF, Roque A,
            McAuliffe GW, Favate J, Garcia-Forn M, Shah P, Judas M, Millonig
            JH, Kostovic I, De Rubeis S, Hart RP, Krsnik Z and Rasin MR.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    GeneRIF: Celf4 controls mRNA translation underlying synaptic
            development in the prenatal mammalian neocortex.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 495)
  AUTHORS   Shen Y, Zhang C, Xiao K, Liu D and Xie G.
  TITLE     CELF4 regulates spine formation and depression-like behaviors of
            mice
  JOURNAL   Biochem Biophys Res Commun 605, 39-44 (2022)
   PUBMED   35306363
  REMARK    GeneRIF: CELF4 regulates spine formation and depression-like
            behaviors of mice.
REFERENCE   3  (residues 1 to 495)
  AUTHORS   Moreau MX, Saillour Y, Cwetsch AW, Pierani A and Causeret F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   4  (residues 1 to 495)
  AUTHORS   Li C, Li X, Bi Z, Sugino K, Wang G, Zhu T and Liu Z.
  TITLE     Comprehensive transcriptome analysis of cochlear spiral ganglion
            neurons at multiple ages
  JOURNAL   Elife 9, e50491 (2020)
   PUBMED   31913118
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 495)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 495)
  AUTHORS   Ladd AN, Taffet G, Hartley C, Kearney DL and Cooper TA.
  TITLE     Cardiac tissue-specific repression of CELF activity disrupts
            alternative splicing and causes cardiomyopathy
  JOURNAL   Mol Cell Biol 25 (14), 6267-6278 (2005)
   PUBMED   15988035
  REMARK    GeneRIF: CELF protein activity is required for normal alternative
            splicing in the heart in vivo and normal CELF-mediated alternative
            splicing regulation is in turn required for normal cardiac
            function.
REFERENCE   7  (residues 1 to 495)
  AUTHORS   Meins M, Schlickum S, Wilhelm C, Missbach J, Yadav S, Glaser B,
            Grzmil M, Burfeind P and Laccone F.
  TITLE     Identification and characterization of murine Brunol4, a new member
            of the elav/bruno family
  JOURNAL   Cytogenet Genome Res 97 (3-4), 254-260 (2002)
   PUBMED   12438720
  REMARK    GeneRIF: cloning and characterization
REFERENCE   8  (residues 1 to 495)
  AUTHORS   Ladd AN, Charlet N and Cooper TA.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   9  (residues 1 to 495)
  AUTHORS   Good PJ, Chen Q, Warner SJ and Herring DC.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
REFERENCE   10 (residues 1 to 495)
  AUTHORS   Yulug IG, Egan SE, See CG and Fisher EM.
  TITLE     Mapping GRB2, a signal transduction gene in the human and the mouse
  JOURNAL   Genomics 22 (2), 313-318 (1994)
   PUBMED   7806216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121094.8, AK048427.1, AF515450.1, BE861427.1, CX242398.1,
            AK038871.1 and AK078071.1.
            
            Transcript Variant: This variant (3) encodes isoform (29, also
            known as C).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF515450.1, SRR1660811.50378.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..495
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 13.92 cM"
     Protein         1..495
                     /product="CUGBP Elav-like family member 4 isoform 29"
                     /note="CUG-BP- and ETR-3-like factor 4; bruno-like protein
                     4; RNA-binding protein BRUNOL-4; bruno-like 4, RNA binding
                     protein"
                     /calculated_mol_wt=52843
     Region          49..135
                     /region_name="RRM1_CELF3_4_5_6"
                     /note="RNA recognition motif 1 (RRM1) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12632"
                     /db_xref="CDD:410041"
     Site            order(55,57,59..60,63,82,84,86,95..97,99,129,131)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410041"
     Region          140..220
                     /region_name="RRM2_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12635"
                     /db_xref="CDD:410043"
     Site            order(142,144,146..147,150,169,171,173,181..183,185,215,
                     217)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410043"
     Region          406..484
                     /region_name="RRM3_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12639"
                     /db_xref="CDD:241083"
     CDS             1..495
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /coded_by="NM_001146294.2:531..2018"
                     /note="isoform 29 is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS89206.1"
                     /db_xref="GeneID:108013"
                     /db_xref="MGI:MGI:1932407"
ORIGIN      
        1 myikmatlan gqadnaslst nglgsspgsa ghmnglshsp gnpstipmkd hdaiklfigq
       61 iprnldekdl kplfeefgki yeltvlkdrf tgmhkgcafl tyceresalk aqsalheqkt
      121 lpgmnrpiqv kpadsesrgd rklfvgmlnk qqseddvrrl feafgnieec tilrgpdgns
      181 kgcafvkyss haeaqaaina lhgsqtmpga ssslvvkfad tdkertmrrm qqmagqmgmf
      241 npmaipfgay gayaqalmqq qaalmasvaq ggylnpmaaf aaaqmqqmaa lnmnglaaap
      301 mtptsggstp pgitapavps ipspigvngf tglppqangq paaeavfang ihpypaqspt
      361 aadplqqaya gvqqyagpaa ypaaygqisq afpqpppmip qqqregpegc nlliyhlpqe
      421 fgdaelmqmf lpfgnvissk vfvdratnqs kcfgfvsfdn pasaqtaiqa mngfqigmkr
      481 lkvqlkrpkd anrpy
//
LOCUS       NP_001152868             329 aa            linear   ROD 09-OCT-2023
DEFINITION  interferon regulatory factor 1 isoform a [Mus musculus].
ACCESSION   NP_001152868
VERSION     NP_001152868.1
DBSOURCE    REFSEQ: accession NM_001159396.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 329)
  AUTHORS   Kong P, Yang M, Wang Y, Yu KN, Wu L and Han W.
  TITLE     Ferroptosis triggered by STAT1- IRF1-ACSL4 pathway was involved in
            radiation-induced intestinal injury
  JOURNAL   Redox Biol 66, 102857 (2023)
   PUBMED   37611494
  REMARK    GeneRIF: Ferroptosis triggered by STAT1- IRF1-ACSL4 pathway was
            involved in radiation-induced intestinal injury.
REFERENCE   2  (residues 1 to 329)
  AUTHORS   Sharma BR, Karki R, Rajesh Y and Kanneganti TD.
  TITLE     Immune regulator IRF1 contributes to ZBP1-, AIM2-, RIPK1-, and
            NLRP12-PANoptosome activation and inflammatory cell death
            (PANoptosis)
  JOURNAL   J Biol Chem 299 (9), 105141 (2023)
   PUBMED   37557956
  REMARK    GeneRIF: Immune regulator IRF1 contributes to ZBP1-, AIM2-, RIPK1-,
            and NLRP12-PANoptosome activation and inflammatory cell death
            (PANoptosis).
REFERENCE   3  (residues 1 to 329)
  AUTHORS   Gungabeesoon J, Gort-Freitas NA, Kiss M, Bolli E, Messemaker M,
            Siwicki M, Hicham M, Bill R, Koch P, Cianciaruso C, Duval F,
            Pfirschke C, Mazzola M, Peters S, Homicsko K, Garris C, Weissleder
            R, Klein AM and Pittet MJ.
  TITLE     A neutrophil response linked to tumor control in immunotherapy
  JOURNAL   Cell 186 (7), 1448-1464 (2023)
   PUBMED   37001504
REFERENCE   4  (residues 1 to 329)
  AUTHORS   Chen X, Qi D, Fan S, He Y, Jing H and Wang D.
  TITLE     Interferon regulatory factor 1 (IRF1) inhibits lung endothelial
            regeneration following inflammation-induced acute lung injury
  JOURNAL   Clin Sci (Lond) 137 (5), 367-383 (2023)
   PUBMED   36857175
  REMARK    GeneRIF: Interferon regulatory factor 1 (IRF1) inhibits lung
            endothelial regeneration following inflammation-induced acute lung
            injury.
REFERENCE   5  (residues 1 to 329)
  AUTHORS   Rosain J, Neehus AL, Manry J, Yang R, Le Pen J, Daher W, Liu Z,
            Chan YH, Tahuil N, Turel O, Bourgey M, Ogishi M, Doisne JM,
            Izquierdo HM, Shirasaki T, Le Voyer T, Guerin A, Bastard P,
            Moncada-Velez M, Han JE, Khan T, Rapaport F, Hong SH, Cheung A,
            Haake K, Mindt BC, Perez L, Philippot Q, Lee D, Zhang P, Rinchai D,
            Al Ali F, Ahmad Ata MM, Rahman M, Peel JN, Heissel S, Molina H,
            Kendir-Demirkol Y, Bailey R, Zhao S, Bohlen J, Mancini M,
            Seeleuthner Y, Roelens M, Lorenzo L, Soudee C, Paz MEJ, Gonzalez
            ML, Jeljeli M, Soulier J, Romana S, L'Honneur AS, Materna M,
            Martinez-Barricarte R, Pochon M, Oleaga-Quintas C, Michev A, Migaud
            M, Levy R, Alyanakian MA, Rozenberg F, Croft CA, Vogt G, Emile JF,
            Kremer L, Ma CS, Fritz JH, Lemon SM, Spaan AN, Manel N, Abel L,
            MacDonald MR, Boisson-Dupuis S, Marr N, Tangye SG, Di Santo JP,
            Zhang Q, Zhang SY, Rice CM, Beziat V, Lachmann N, Langlais D,
            Casanova JL, Gros P and Bustamante J.
  TITLE     Human IRF1 governs macrophagic IFN-gamma immunity to mycobacteria
  JOURNAL   Cell 186 (3), 621-645 (2023)
   PUBMED   36736301
REFERENCE   6  (residues 1 to 329)
  AUTHORS   Gribaudo G, Caliendo A, Lembo D, Cavallo R and Landolfo S.
  TITLE     Molecular cloning of interferon-gamma inducible genes from a murine
            pre-B cell leukemia
  JOURNAL   J Biol Regul Homeost Agents 6 (4), 137-141 (1992)
   PUBMED   1296455
REFERENCE   7  (residues 1 to 329)
  AUTHORS   Tanaka N and Taniguchi T.
  TITLE     Cytokine gene regulation: regulatory cis-elements and DNA binding
            factors involved in the interferon system
  JOURNAL   Adv Immunol 52, 263-281 (1992)
   PUBMED   1442307
  REMARK    Review article
REFERENCE   8  (residues 1 to 329)
  AUTHORS   Buckwalter MS, Lossie AC, Scarlett LM and Camper SA.
  TITLE     Localization of the human chromosome 5q genes Gabra-1, Gabrg-2,
            Il-4, Il-5, and Irf-1 on mouse chromosome 11
  JOURNAL   Mamm Genome 3 (10), 604-607 (1992)
   PUBMED   1358285
REFERENCE   9  (residues 1 to 329)
  AUTHORS   Driggers PH, Ennist DL, Gleason SL, Mak WH, Marks MS, Levi BZ,
            Flanagan JR, Appella E and Ozato K.
  TITLE     An interferon gamma-regulated protein that binds the
            interferon-inducible enhancer element of major histocompatibility
            complex class I genes
  JOURNAL   Proc Natl Acad Sci U S A 87 (10), 3743-3747 (1990)
   PUBMED   2111015
REFERENCE   10 (residues 1 to 329)
  AUTHORS   Harada H, Fujita T, Miyamoto M, Kimura Y, Maruyama M, Furia A,
            Miyata T and Taniguchi T.
  TITLE     Structurally similar but functionally distinct factors, IRF-1 and
            IRF-2, bind to the same regulatory elements of IFN and
            IFN-inducible genes
  JOURNAL   Cell 58 (4), 729-739 (1989)
   PUBMED   2475256
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY328342.1, AK152005.1 and BE950981.1.
            
            Transcript Variant: This variant (2) represents use of an alternate
            promoter and 5' non-coding exon, compared to variant 1, and encodes
            the longer isoform (a). Both variants 1 and 2 encode the same
            isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003821.1, SRR11927937.5004821.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..329
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 32.0 cM"
     Protein         1..329
                     /product="interferon regulatory factor 1 isoform a"
                     /calculated_mol_wt=37188
     Region          7..112
                     /region_name="IRF"
                     /note="Interferon regulatory factor transcription factor;
                     pfam00605"
                     /db_xref="CDD:425772"
     Site            order(40,80,82..83,86)
                     /site_type="other"
                     /note="DNA sequence recognition sites [nucleotide
                     binding]"
                     /db_xref="CDD:238051"
     Site            78
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P10914; propagated from
                     UniProtKB/Swiss-Prot (P15314.1)"
     Site            order(85..86,88,91)
                     /site_type="metal-binding"
                     /db_xref="CDD:238051"
     Region          93..166
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P15314.1)"
     CDS             1..329
                     /gene="Irf1"
                     /gene_synonym="Irf-1"
                     /coded_by="NM_001159396.1:225..1214"
                     /note="isoform a is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS24686.1"
                     /db_xref="GeneID:16362"
                     /db_xref="MGI:MGI:96590"
ORIGIN      
        1 mpitrmrmrp wlemqinsnq ipgliwinke emifqipwkh aakhgwdink daclfrswai
       61 htgrykagek epdpktwkan frcamnslpd ieevkdqsrn kgssavrvyr mlppltrnqr
      121 kerkskssrd tksktkrklc gdvspdtfsd glssstlpdd hssyttqgyl gqdldmerdi
      181 tpalspcvvs sslsewhmqm diipdsttdl ynlqvspmps tseaatdede egkiaedlmk
      241 lfeqsewqpt hidgkgylln epgtqlssvy gdfsckeepe idsprgdigi giqhvftemk
      301 nmdsimwmds llgnsvrlpp siqaipcap
//
LOCUS       NP_001349207             543 aa            linear   ROD 09-OCT-2023
DEFINITION  CUGBP Elav-like family member 4 isoform 4 [Mus musculus].
ACCESSION   NP_001349207
VERSION     NP_001349207.1
DBSOURCE    REFSEQ: accession NM_001362278.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 543)
  AUTHORS   Salamon I, Park Y, Miskic T, Kopic J, Matteson P, Page NF, Roque A,
            McAuliffe GW, Favate J, Garcia-Forn M, Shah P, Judas M, Millonig
            JH, Kostovic I, De Rubeis S, Hart RP, Krsnik Z and Rasin MR.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    GeneRIF: Celf4 controls mRNA translation underlying synaptic
            development in the prenatal mammalian neocortex.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 543)
  AUTHORS   Shen Y, Zhang C, Xiao K, Liu D and Xie G.
  TITLE     CELF4 regulates spine formation and depression-like behaviors of
            mice
  JOURNAL   Biochem Biophys Res Commun 605, 39-44 (2022)
   PUBMED   35306363
  REMARK    GeneRIF: CELF4 regulates spine formation and depression-like
            behaviors of mice.
REFERENCE   3  (residues 1 to 543)
  AUTHORS   Moreau MX, Saillour Y, Cwetsch AW, Pierani A and Causeret F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   4  (residues 1 to 543)
  AUTHORS   Li C, Li X, Bi Z, Sugino K, Wang G, Zhu T and Liu Z.
  TITLE     Comprehensive transcriptome analysis of cochlear spiral ganglion
            neurons at multiple ages
  JOURNAL   Elife 9, e50491 (2020)
   PUBMED   31913118
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 543)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 543)
  AUTHORS   Ladd AN, Taffet G, Hartley C, Kearney DL and Cooper TA.
  TITLE     Cardiac tissue-specific repression of CELF activity disrupts
            alternative splicing and causes cardiomyopathy
  JOURNAL   Mol Cell Biol 25 (14), 6267-6278 (2005)
   PUBMED   15988035
  REMARK    GeneRIF: CELF protein activity is required for normal alternative
            splicing in the heart in vivo and normal CELF-mediated alternative
            splicing regulation is in turn required for normal cardiac
            function.
REFERENCE   7  (residues 1 to 543)
  AUTHORS   Meins M, Schlickum S, Wilhelm C, Missbach J, Yadav S, Glaser B,
            Grzmil M, Burfeind P and Laccone F.
  TITLE     Identification and characterization of murine Brunol4, a new member
            of the elav/bruno family
  JOURNAL   Cytogenet Genome Res 97 (3-4), 254-260 (2002)
   PUBMED   12438720
  REMARK    GeneRIF: cloning and characterization
REFERENCE   8  (residues 1 to 543)
  AUTHORS   Ladd AN, Charlet N and Cooper TA.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   9  (residues 1 to 543)
  AUTHORS   Good PJ, Chen Q, Warner SJ and Herring DC.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
REFERENCE   10 (residues 1 to 543)
  AUTHORS   Yulug IG, Egan SE, See CG and Fisher EM.
  TITLE     Mapping GRB2, a signal transduction gene in the human and the mouse
  JOURNAL   Genomics 22 (2), 313-318 (1994)
   PUBMED   7806216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121094.8 and AC144938.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164131,
                              SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..543
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 13.92 cM"
     Protein         1..543
                     /product="CUGBP Elav-like family member 4 isoform 4"
                     /note="CUG-BP- and ETR-3-like factor 4; bruno-like protein
                     4; RNA-binding protein BRUNOL-4; bruno-like 4, RNA binding
                     protein"
                     /calculated_mol_wt=57863
     Region          49..135
                     /region_name="RRM1_CELF3_4_5_6"
                     /note="RNA recognition motif 1 (RRM1) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12632"
                     /db_xref="CDD:410041"
     Site            order(55,57,59..60,63,82,84,86,95..97,99,129,131)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410041"
     Region          140..220
                     /region_name="RRM2_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12635"
                     /db_xref="CDD:410043"
     Site            order(142,144,146..147,150,169,171,173,181..183,185,215,
                     217)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410043"
     Region          404..>452
                     /region_name="RRM_SF"
                     /note="RNA recognition motif (RRM) superfamily; cl17169"
                     /db_xref="CDD:450164"
     CDS             1..543
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /coded_by="NM_001362278.1:531..2162"
                     /note="isoform 4 is encoded by transcript variant 10"
                     /db_xref="GeneID:108013"
                     /db_xref="MGI:MGI:1932407"
ORIGIN      
        1 myikmatlan gqadnaslst nglgsspgsa ghmnglshsp gnpstipmkd hdaiklfigq
       61 iprnldekdl kplfeefgki yeltvlkdrf tgmhkgcafl tyceresalk aqsalheqkt
      121 lpgmnrpiqv kpadsesrgd rklfvgmlnk qqseddvrrl feafgnieec tilrgpdgns
      181 kgcafvkyss haeaqaaina lhgsqtmpga ssslvvkfad tdkertmrrm qqmagqmgmf
      241 npmaipfgay gayaqamqqq aalmasvaqg gylnpmaafa aaqmqqmaal nmnglaaapm
      301 tptsggstpp gitapavpsi pspigvngft glppqangqp aaeavfangi hpypaqspta
      361 adplqqayag vqqyagpayp aaygqisqaf pqpppmipqq qregpegcnl liyhlpqefg
      421 daelmqmflp fgnvisskvf vdratnqskc fgrhpvpsrc qapscqggqc aisssarrlr
      481 elrqpgqrtd rhpgherlpd rheeaqgaae aaqrrqspvl saggsvprgr pglaqgrmln
      541 glh
//
LOCUS       NP_036066                502 aa            linear   ROD 09-OCT-2023
DEFINITION  alpha-ketoglutarate-dependent dioxygenase FTO [Mus musculus].
ACCESSION   NP_036066
VERSION     NP_036066.2
DBSOURCE    REFSEQ: accession NM_011936.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 502)
  AUTHORS   Zhou C, She X, Gu C, Hu Y, Ma M, Qiu Q, Sun T, Xu X, Chen H and
            Zheng Z.
  TITLE     FTO fuels diabetes-induced vascular endothelial dysfunction
            associated with inflammation by erasing m6A methylation of TNIP1
  JOURNAL   J Clin Invest 133 (19), e160517 (2023)
   PUBMED   37781923
  REMARK    GeneRIF: FTO fuels diabetes-induced vascular endothelial
            dysfunction associated with inflammation by erasing m6A methylation
            of TNIP1.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 502)
  AUTHORS   Zhang J, Wei J, Sun R, Sheng H, Yin K, Pan Y, Jimenez R, Chen S,
            Cui XL, Zou Z, Yue Z, Emch MJ, Hawse JR, Wang L, He HH, Xia S, Han
            B, He C and Huang H.
  TITLE     A lncRNA from the FTO locus acts as a suppressor of the m6A writer
            complex and p53 tumor suppression signaling
  JOURNAL   Mol Cell 83 (15), 2692-2708 (2023)
   PUBMED   37478845
  REMARK    GeneRIF: A lncRNA from the FTO locus acts as a suppressor of the
            m[6]A writer complex and p53 tumor suppression signaling.
REFERENCE   3  (residues 1 to 502)
  AUTHORS   Wang W, Du X, Luo M and Yang N.
  TITLE     FTO-dependent m6A regulates muscle fiber remodeling in an
            NFATC1-YTHDF2 dependent manner
  JOURNAL   Clin Epigenetics 15 (1), 109 (2023)
   PUBMED   37408034
  REMARK    GeneRIF: FTO-dependent m[6]A regulates muscle fiber remodeling in
            an NFATC1-YTHDF2 dependent manner.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 502)
  AUTHORS   Li L, Sun Y, Davis AE, Shah SH, Hamed LK, Wu MR, Lin CH, Ding JB
            and Wang S.
  TITLE     Mettl14-mediated m6A modification ensures the cell-cycle
            progression of late-born retinal progenitor cells
  JOURNAL   Cell Rep 42 (6), 112596 (2023)
   PUBMED   37269288
REFERENCE   5  (residues 1 to 502)
  AUTHORS   Zhou SM, Li JZ, Chen HQ, Zeng Y, Yuan WB, Shi Y, Wang N, Fan J,
            Zhang Z, Xu Y, Cao J and Liu WB.
  TITLE     FTO-Nrf2 axis regulates bisphenol F-induced leydig cell toxicity in
            an m6A-YTHDF2-dependent manner
  JOURNAL   Environ Pollut 325, 121393 (2023)
   PUBMED   36878272
  REMARK    GeneRIF: FTO-Nrf2 axis regulates bisphenol F-induced leydig cell
            toxicity in an m6A-YTHDF2-dependent manner.
REFERENCE   6  (residues 1 to 502)
  AUTHORS   Okazaki N, Kikuno R, Ohara R, Inamoto S, Koseki H, Hiraoka S, Saga
            Y, Nagase T, Ohara O and Koga H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   7  (residues 1 to 502)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (residues 1 to 502)
  AUTHORS   Peters T, Ausmeier K, Dildrop R and Ruther U.
  TITLE     The mouse Fused toes (Ft) mutation is the result of a 1.6-Mb
            deletion including the entire Iroquois B gene cluster
  JOURNAL   Mamm Genome 13 (4), 186-188 (2002)
   PUBMED   11956760
REFERENCE   9  (residues 1 to 502)
  AUTHORS   Peters T, Ausmeier K and Ruther U.
  TITLE     Cloning of Fatso (Fto), a novel gene deleted by the Fused toes (Ft)
            mouse mutation
  JOURNAL   Mamm Genome 10 (10), 983-986 (1999)
   PUBMED   10501967
REFERENCE   10 (residues 1 to 502)
  AUTHORS   Araki K, Imaizumi T, Sekimoto T, Yoshinobu K, Yoshimuta J, Akizuki
            M, Miura K, Araki M and Yamamura K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY290198.1, BC057008.1 and CA321822.1.
            
            On Feb 5, 2008 this sequence version replaced NP_036066.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057008.1, AJ237917.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 44.34 cM"
     Protein         1..502
                     /product="alpha-ketoglutarate-dependent dioxygenase FTO"
                     /EC_number="1.14.11.53"
                     /note="protein fatso; fat mass and obesity-associated
                     protein; m6A(m)-demethylase FTO; tRNA N1-methyl adenine
                     demethylase FTO; mRNA N(6)-methyladenosine demethylase
                     FTO; mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO; U6
                     small nuclear RNA N(6)-methyladenosine-demethylase FTO;
                     fat mass and obesity associated; U6 small nuclear RNA
                     (2'-O-methyladenosine-N(6)-)-demethylase FTO"
                     /calculated_mol_wt=57876
     Region          32..324
                     /region_name="Fe2OG dioxygenase domain.
                     /evidence=ECO:0000250|UniProtKB:Q9C0B1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BGW1.1)"
     Region          36..322
                     /region_name="FTO_NTD"
                     /note="FTO catalytic domain; pfam12933"
                     /db_xref="CDD:432886"
     Region          210..221
                     /region_name="Loop L1, predicted to block binding of
                     double-stranded DNA or RNA.
                     /evidence=ECO:0000250|UniProtKB:Q9C0B1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BGW1.1)"
     Site            213
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q9C0B1; propagated from
                     UniProtKB/Swiss-Prot (Q8BGW1.1)"
     Region          326..495
                     /region_name="FTO_CTD"
                     /note="FTO C-terminal domain; pfam12934"
                     /db_xref="CDD:432887"
     CDS             1..502
                     /gene="Fto"
                     /gene_synonym="mKIAA1752"
                     /coded_by="NM_011936.2:52..1560"
                     /db_xref="CCDS:CCDS22521.1"
                     /db_xref="GeneID:26383"
                     /db_xref="MGI:MGI:1347093"
ORIGIN      
        1 mkrvqtaeer ereakklrll eeledtwlpy ltpkddefyq qwqlkypklv freagsipee
       61 lhkevpeafl tlhkhgclfr dvvriqgkdv ltpvsrilig dpgctykyln trlftvpwpv
      121 kgctvkytea eiaaacqtfl klndylqvet iqaleelavr ekanedavpl cmaefpragv
      181 gpscddevdl ksraaynvtl lnfmdpqkmp ylkeepyfgm gkmavswhhd enlvdrsava
      241 vysyscegse desedessfe grdpdtwhvg fkiswdietp gltiplhqgd cyfmlddlna
      301 thqhcvlags qprfssthrv aecstgtldy ilercqlalq nvlndsddgd vslksfdpav
      361 lkqgeeihne vefewlrqfw fqgnryklct dwwcepmthl eglwkkmesm tnavlrevkr
      421 eglpveqrse ilsailvplt vrqnlrkewh arcqsrvvrt lpvqqkpdcr pywekddpsm
      481 plpfdltdvv selrgqllea rs
//
LOCUS       NP_001349208             536 aa            linear   ROD 09-OCT-2023
DEFINITION  CUGBP Elav-like family member 4 isoform 5 [Mus musculus].
ACCESSION   NP_001349208 XP_017173274
VERSION     NP_001349208.1
DBSOURCE    REFSEQ: accession NM_001362279.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 536)
  AUTHORS   Salamon I, Park Y, Miskic T, Kopic J, Matteson P, Page NF, Roque A,
            McAuliffe GW, Favate J, Garcia-Forn M, Shah P, Judas M, Millonig
            JH, Kostovic I, De Rubeis S, Hart RP, Krsnik Z and Rasin MR.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    GeneRIF: Celf4 controls mRNA translation underlying synaptic
            development in the prenatal mammalian neocortex.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 536)
  AUTHORS   Shen Y, Zhang C, Xiao K, Liu D and Xie G.
  TITLE     CELF4 regulates spine formation and depression-like behaviors of
            mice
  JOURNAL   Biochem Biophys Res Commun 605, 39-44 (2022)
   PUBMED   35306363
  REMARK    GeneRIF: CELF4 regulates spine formation and depression-like
            behaviors of mice.
REFERENCE   3  (residues 1 to 536)
  AUTHORS   Moreau MX, Saillour Y, Cwetsch AW, Pierani A and Causeret F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   4  (residues 1 to 536)
  AUTHORS   Li C, Li X, Bi Z, Sugino K, Wang G, Zhu T and Liu Z.
  TITLE     Comprehensive transcriptome analysis of cochlear spiral ganglion
            neurons at multiple ages
  JOURNAL   Elife 9, e50491 (2020)
   PUBMED   31913118
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 536)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 536)
  AUTHORS   Ladd AN, Taffet G, Hartley C, Kearney DL and Cooper TA.
  TITLE     Cardiac tissue-specific repression of CELF activity disrupts
            alternative splicing and causes cardiomyopathy
  JOURNAL   Mol Cell Biol 25 (14), 6267-6278 (2005)
   PUBMED   15988035
  REMARK    GeneRIF: CELF protein activity is required for normal alternative
            splicing in the heart in vivo and normal CELF-mediated alternative
            splicing regulation is in turn required for normal cardiac
            function.
REFERENCE   7  (residues 1 to 536)
  AUTHORS   Meins M, Schlickum S, Wilhelm C, Missbach J, Yadav S, Glaser B,
            Grzmil M, Burfeind P and Laccone F.
  TITLE     Identification and characterization of murine Brunol4, a new member
            of the elav/bruno family
  JOURNAL   Cytogenet Genome Res 97 (3-4), 254-260 (2002)
   PUBMED   12438720
  REMARK    GeneRIF: cloning and characterization
REFERENCE   8  (residues 1 to 536)
  AUTHORS   Ladd AN, Charlet N and Cooper TA.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   9  (residues 1 to 536)
  AUTHORS   Good PJ, Chen Q, Warner SJ and Herring DC.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
REFERENCE   10 (residues 1 to 536)
  AUTHORS   Yulug IG, Egan SE, See CG and Fisher EM.
  TITLE     Mapping GRB2, a signal transduction gene in the human and the mouse
  JOURNAL   Genomics 22 (2), 313-318 (1994)
   PUBMED   7806216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121094.8 and AC144938.3.
            
            On Apr 12, 2018 this sequence version replaced XP_017173274.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.265626.1,
                                           SRR10662772.82830.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..536
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 13.92 cM"
     Protein         1..536
                     /product="CUGBP Elav-like family member 4 isoform 5"
                     /note="CUG-BP- and ETR-3-like factor 4; bruno-like protein
                     4; RNA-binding protein BRUNOL-4; bruno-like 4, RNA binding
                     protein"
                     /calculated_mol_wt=57006
     Region          1..298
                     /region_name="Sufficient for RNA-binding and MSE-dependent
                     splicing activity. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          18..39
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          49..135
                     /region_name="RRM1_CELF3_4_5_6"
                     /note="RNA recognition motif 1 (RRM1) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12632"
                     /db_xref="CDD:410041"
     Site            order(55,57,59..60,63,82,84,86,95..97,99,129,131)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410041"
     Region          <56..378
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     Region          121..149
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          151..231
                     /region_name="RRM2_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12635"
                     /db_xref="CDD:410043"
     Site            order(153,155,157..158,161,180,182,184,192..194,196,226,
                     228)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410043"
     Region          239..258
                     /region_name="Necessary for TNNT2 exon 5 inclusion.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          417..>445
                     /region_name="RRM_SF"
                     /note="RNA recognition motif (RRM) superfamily; cl17169"
                     /db_xref="CDD:450164"
     CDS             1..536
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /coded_by="NM_001362279.1:531..2141"
                     /note="isoform 5 is encoded by transcript variant 11"
                     /db_xref="GeneID:108013"
                     /db_xref="MGI:MGI:1932407"
ORIGIN      
        1 myikmatlan gqadnaslst nglgsspgsa ghmnglshsp gnpstipmkd hdaiklfigq
       61 iprnldekdl kplfeefgki yeltvlkdrf tgmhkgcafl tyceresalk aqsalheqkt
      121 lpgmnrpiqv kpadsesrgg ssclrqppsq drklfvgmln kqqseddvrr lfeafgniee
      181 ctilrgpdgn skgcafvkys shaeaqaain alhgsqtmpg assslvvkfa dtdkertmrr
      241 mqqmagqmgm fnpmaipfga ygayaqalmq qqaalmasva qggylnpmaa faaaqmqqma
      301 alnmnglaaa pmtptsggst ppgitapavp sipspigvng ftglppqang qpaaeavfan
      361 gihpypaqsp taadplqqay agvqqyagpa aypaaygqis qafpqpppmi pqqqregpeg
      421 cnlliyhlpq efgdaelmqm flpfgrhpvp srcqapscqg gqcaisssar rlrelrqpgq
      481 rtdrhpgher lpdrheeaqg aaeaaqrrqs pvlsaggsvp rgrpglaqgr mlnglh
//
LOCUS       NP_001334161             433 aa            linear   ROD 09-OCT-2023
DEFINITION  glycogen synthase kinase-3 beta isoform 2 [Mus musculus].
ACCESSION   NP_001334161 XP_006522488
VERSION     NP_001334161.1
DBSOURCE    REFSEQ: accession NM_001347232.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 433)
  AUTHORS   Fu Y, Wang J, Liu C, Liao K, Gao X, Tang R, Fan B, Hong Y, Xiao N,
            Xiao C and Liu WH.
  TITLE     Glycogen synthase kinase 3 controls T-cell exhaustion by regulating
            NFAT activation
  JOURNAL   Cell Mol Immunol 20 (10), 1127-1139 (2023)
   PUBMED   37553428
  REMARK    GeneRIF: Glycogen synthase kinase 3 controls T-cell exhaustion by
            regulating NFAT activation.
REFERENCE   2  (residues 1 to 433)
  AUTHORS   Brishti MA, Raghavan S, Lamar K, Singh UP, Collier DM and Leo MD.
  TITLE     Diabetic Endothelial Cell Glycogen Synthase Kinase 3beta Activation
            Induces VCAM1 Ectodomain Shedding
  JOURNAL   Int J Mol Sci 24 (18), 14105 (2023)
   PUBMED   37762417
  REMARK    GeneRIF: Diabetic Endothelial Cell Glycogen Synthase Kinase 3beta
            Activation Induces VCAM1 Ectodomain Shedding.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 433)
  AUTHORS   Sunilkumar S, VanCleave AM, McCurry CM, Toro AL, Stevens SA,
            Kimball SR and Dennis MD.
  TITLE     REDD1-dependent GSK3beta dephosphorylation promotes NF-kappaB
            activation and macrophage infiltration in the retina of diabetic
            mice
  JOURNAL   J Biol Chem 299 (8), 104991 (2023)
   PUBMED   37392853
  REMARK    GeneRIF: REDD1-dependent GSK3beta dephosphorylation promotes
            NF-kappaB activation and macrophage infiltration in the retina of
            diabetic mice.
REFERENCE   4  (residues 1 to 433)
  AUTHORS   Cai X, Zhao Y, Yang Y, Wu X, Zhang L, Ma JA, Ji J, Bostrom KI and
            Yao Y.
  TITLE     GSK3beta Inhibition Ameliorates Atherosclerotic Calcification
  JOURNAL   Int J Mol Sci 24 (14), 11638 (2023)
   PUBMED   37511396
  REMARK    GeneRIF: GSK3beta Inhibition Ameliorates Atherosclerotic
            Calcification.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 433)
  AUTHORS   Sun L, Zhang X, Wu S, Liu Y, Guerrero-Juarez CF, Liu W, Huang J,
            Yao Q, Yin M, Li J, Ramos R, Liao Y, Wu R, Xia T, Zhang X, Yang Y,
            Li F, Heng S, Zhang W, Yang M, Tzeng CM, Ji C, Plikus MV, Gallo RL
            and Zhang LJ.
  TITLE     Dynamic interplay between IL-1 and WNT pathways in regulating
            dermal adipocyte lineage cells during skin development and wound
            regeneration
  JOURNAL   Cell Rep 42 (6), 112647 (2023)
   PUBMED   37330908
REFERENCE   6  (residues 1 to 433)
  AUTHORS   Sakanaka C and Williams LT.
  TITLE     Functional domains of axin. Importance of the C terminus as an
            oligomerization domain
  JOURNAL   J Biol Chem 274 (20), 14090-14093 (1999)
   PUBMED   10318824
REFERENCE   7  (residues 1 to 433)
  AUTHORS   Diehl JA, Cheng M, Roussel MF and Sherr CJ.
  TITLE     Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and
            subcellular localization
  JOURNAL   Genes Dev 12 (22), 3499-3511 (1998)
   PUBMED   9832503
REFERENCE   8  (residues 1 to 433)
  AUTHORS   Hart MJ, de los Santos R, Albert IN, Rubinfeld B and Polakis P.
  TITLE     Downregulation of beta-catenin by human Axin and its association
            with the APC tumor suppressor, beta-catenin and GSK3 beta
  JOURNAL   Curr Biol 8 (10), 573-581 (1998)
   PUBMED   9601641
REFERENCE   9  (residues 1 to 433)
  AUTHORS   Behrens J, Jerchow BA, Wurtele M, Grimm J, Asbrand C, Wirtz R, Kuhl
            M, Wedlich D and Birchmeier W.
  TITLE     Functional interaction of an axin homolog, conductin, with
            beta-catenin, APC, and GSK3beta
  JOURNAL   Science 280 (5363), 596-599 (1998)
   PUBMED   9554852
REFERENCE   10 (residues 1 to 433)
  AUTHORS   Cohen,J.S.
  TITLE     Provide fluoxetine information vital to clinicians
  JOURNAL   J Clin Psychiatry 56 (12), 591 (1995)
   PUBMED   8530339
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC120020.9 and AC154284.1.
            
            On Nov 18, 2016 this sequence version replaced XP_006522488.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219380.3497.1,
                                           SRR7652917.564182.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..433
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 26.54 cM"
     Protein         1..433
                     /product="glycogen synthase kinase-3 beta isoform 2"
                     /EC_number="2.7.11.1"
                     /EC_number="2.7.11.26"
                     /note="serine/threonine-protein kinase GSK3B"
                     /calculated_mol_wt=47859
     Region          51..356
                     /region_name="STKc_GSK3"
                     /note="The catalytic domain of the Serine/Threonine
                     Kinase, Glycogen Synthase Kinase 3; cd14137"
                     /db_xref="CDD:271039"
     Site            order(62..66,70,83,85,96,110,132..135,138,140..141,181,
                     183,185..186,188,200,203,214,216..219,221,259)
                     /site_type="active"
                     /db_xref="CDD:271039"
     Site            order(62..65,70,83,85,110,132..135,138,183,185..186,188,
                     200)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271039"
     Site            order(66..67,212..220,228..229,260..264,266..267,271,
                     291..294)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:271039"
     Site            order(96,140,181,183,203,214,216..219,221,259)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:271039"
     Site            order(199..209,211..221)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:271039"
     Site            order(228,263..264,266..267,270..271,291..296)
                     /site_type="other"
                     /note="axin binding site [polypeptide binding]"
                     /db_xref="CDD:271039"
     CDS             1..433
                     /gene="Gsk3b"
                     /gene_synonym="7330414F15Rik; 8430431H08Rik; GSK-3;
                     GSK-3beta; GSK3"
                     /coded_by="NM_001347232.1:1526..2827"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS84232.1"
                     /db_xref="GeneID:56637"
                     /db_xref="MGI:MGI:1861437"
ORIGIN      
        1 msgrprttsf aesckpvqqp safgsmkvsr dkdgskvttv vatpgqgpdr pqevsytdtk
       61 vigngsfgvv yqaklcdsge lvaikkvlqd krfknrelqi mrkldhcniv rlryffyssg
      121 ekkdevylnl vldyvpetvy rvarhysrak qtlpviyvkl ymyqlfrsla yihsfgichr
      181 dikpqnllld pdtavlklcd fgsakqlvrg epnvsyicsr yyrapelifg atdytssidv
      241 wsagcvlael llgqpifpgd sgvdqlveii kvlgtptreq iremnpnyte fkfpqikahp
      301 wtkdspgagh ftpgvrvfrp rtppeaialc srlleytpta rltpleacah sffdelrdpn
      361 vklpngrdtp alfnfttqel ssnpplatil ipphariqaa asppanataa sdtnagdrgq
      421 tnnaasasas nst
//
LOCUS       NP_035329                591 aa            linear   ROD 09-OCT-2023
DEFINITION  parathyroid hormone/parathyroid hormone-related peptide receptor
            precursor [Mus musculus].
ACCESSION   NP_035329
VERSION     NP_035329.2
DBSOURCE    REFSEQ: accession NM_011199.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 591)
  AUTHORS   Amano K, Kitaoka Y, Kato S, Fujiwara M, Okuzaki D, Aikawa T, Kogo M
            and Iida S.
  TITLE     Pth1r Signal in Gli1+ Cells Maintains Postnatal Cranial Base
            Synchondrosis
  JOURNAL   J Dent Res 102 (11), 1241-1251 (2023)
   PUBMED   37575041
  REMARK    GeneRIF: Pth1r Signal in Gli1+ Cells Maintains Postnatal Cranial
            Base Synchondrosis.
REFERENCE   2  (residues 1 to 591)
  AUTHORS   Liu H, Wada A, Le I, Le PT, Lee AWF, Zhou J, Gori F, Baron R and
            Rosen CJ.
  TITLE     PTH regulates osteogenesis and suppresses adipogenesis through
            Zfp467 in a feed-forward, PTH1R-cyclic AMP-dependent manner
  JOURNAL   Elife 12, e83345 (2023)
   PUBMED   37159501
  REMARK    GeneRIF: PTH regulates osteogenesis and suppresses adipogenesis
            through Zfp467 in a feed-forward, PTH1R-cyclic AMP-dependent
            manner.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 591)
  AUTHORS   Chu TL, Chen P, Yu AX, Kong M, Tan Z, Tsang KY, Zhou Z and Cheah
            KSE.
  TITLE     MMP14 cleaves PTH1R in the chondrocyte-derived osteoblast lineage,
            curbing signaling intensity for proper bone anabolism
  JOURNAL   Elife 12, e82142 (2023)
   PUBMED   36892459
  REMARK    GeneRIF: MMP14 cleaves PTH1R in the chondrocyte-derived osteoblast
            lineage, curbing signaling intensity for proper bone anabolism.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 591)
  AUTHORS   Wang F, Rummukainen P, Pehkonen M, Saamanen AM, Heino TJ and
            Kiviranta R.
  TITLE     Mesenchymal cell-derived Wnt1 signaling regulates subchondral bone
            remodeling but has no effects on the development of growth plate or
            articular cartilage in mice
  JOURNAL   Bone 163, 116497 (2022)
   PUBMED   35863746
REFERENCE   5  (residues 1 to 591)
  AUTHORS   Kimura T, Panaroni C, Rankin EB, Purton LE and Wu JY.
  TITLE     Loss of Parathyroid Hormone Receptor Signaling in Osteoprogenitors
            Is Associated With Accumulation of Multiple Hematopoietic Lineages
            in the Bone Marrow
  JOURNAL   J Bone Miner Res 37 (7), 1321-1334 (2022)
   PUBMED   35490308
  REMARK    GeneRIF: Loss of Parathyroid Hormone Receptor Signaling in
            Osteoprogenitors Is Associated With Accumulation of Multiple
            Hematopoietic Lineages in the Bone Marrow.
REFERENCE   6  (residues 1 to 591)
  AUTHORS   McCuaig KA, Lee HS, Clarke JC, Assar H, Horsford J and White JH.
  TITLE     Parathyroid hormone/parathyroid hormone related peptide receptor
            gene transcripts are expressed from tissue-specific and ubiquitous
            promoters
  JOURNAL   Nucleic Acids Res 23 (11), 1948-1955 (1995)
   PUBMED   7596823
  REMARK    Erratum:[Nucleic Acids Res 1995 Aug 11;23(15):3082]
REFERENCE   7  (residues 1 to 591)
  AUTHORS   Karperien M, van Dijk TB, Hoeijmakers T, Cremers F, Abou-Samra AB,
            Boonstra J, de Laat SW and Defize LH.
  TITLE     Expression pattern of parathyroid hormone/parathyroid hormone
            related peptide receptor mRNA in mouse postimplantation embryos
            indicates involvement in multiple developmental processes
  JOURNAL   Mech Dev 47 (1), 29-42 (1994)
   PUBMED   7524627
REFERENCE   8  (residues 1 to 591)
  AUTHORS   Kong XF, Schipani E, Lanske B, Joun H, Karperien M, Defize LH,
            Juppner H, Potts JT Jr, Segre GV, Kronenberg HM et al.
  TITLE     The rat, mouse and human genes encoding the receptor for
            parathyroid hormone and parathyroid hormone-related peptide are
            highly homologous
  JOURNAL   Biochem Biophys Res Commun 200 (3), 1290-1299 (1994)
   PUBMED   8185578
  REMARK    Erratum:[Biochem Biophys Res Commun. 1994 Jun 15;201(2):1058. PMID:
            8002976]
REFERENCE   9  (residues 1 to 591)
  AUTHORS   Pausova Z, Bourdon J, Clayton D, Mattei MG, Seldin MF, Janicic N,
            Riviere M, Szpirer J, Levan G, Szpirer C et al.
  TITLE     Cloning of a parathyroid hormone/parathyroid hormone-related
            peptide receptor (PTHR) cDNA from a rat osteosarcoma (UMR 106) cell
            line: chromosomal assignment of the gene in the human, mouse, and
            rat genomes
  JOURNAL   Genomics 20 (1), 20-26 (1994)
   PUBMED   8020952
REFERENCE   10 (residues 1 to 591)
  AUTHORS   Seldin MF, Mattei MG and Hendy GN.
  TITLE     Localization of mouse parathyroid hormone-like peptide gene (Pthlh)
            to distal chromosome 6 using interspecific backcross mice and in
            situ hybridization
  JOURNAL   Cytogenet Cell Genet 60 (3-4), 252-254 (1992)
   PUBMED   1354597
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC139378.4, BY005592.1, BC051981.1 and AI607947.1.
            
            On Apr 14, 2007 this sequence version replaced NP_035329.1.
            
            Transcript Variant: This variant (1) differs in the 5' UTR,
            compared to variant 3. Variants 1, 2, and 3 encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC013446.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..591
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 60.56 cM"
     Protein         1..591
                     /product="parathyroid hormone/parathyroid hormone-related
                     peptide receptor precursor"
                     /note="parathyroid hormone receptor 1; parathyroid
                     hormone/parathyroid hormone-related peptide receptor; PTH1
                     receptor; PTH/PTHr receptor; PTH/PTHrP type I receptor;
                     PTH-related peptide receptor; PTH/PTHrP receptor"
                     /calculated_mol_wt=63570
     sig_peptide     1..28
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=2820
     Region          67..104
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P41593.2)"
     Region          105..170
                     /region_name="HRM"
                     /note="Hormone receptor domain; pfam02793"
                     /db_xref="CDD:397086"
     Site            151
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P41593.2)"
     Site            161
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P41593.2)"
     Site            166
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P41593.2)"
     Site            176
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P41593.2)"
     Region          184..476
                     /region_name="7tm_GPCRs"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; cl28897"
                     /db_xref="CDD:452889"
     Region          187..211
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:410628"
     Site            189..212
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P41593.2)"
     Region          220..241
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:410628"
     Site            220..239
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P41593.2)"
     Region          282..304
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:410628"
     Site            283..306
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P41593.2)"
     Site            321..342
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P41593.2)"
     Region          323..339
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:410628"
     Region          356..379
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:410628"
     Site            362..382
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P41593.2)"
     Region          407..429
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:410628"
     Site            410..428
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P41593.2)"
     Region          438..463
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:410628"
     Site            441..463
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P41593.2)"
     Region          474..477
                     /region_name="Important for interaction with G proteins.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P41593.2)"
     CDS             1..591
                     /gene="Pth1r"
                     /gene_synonym="PPR; Pthr; Pthr1"
                     /coded_by="NM_011199.2:280..2055"
                     /db_xref="CCDS:CCDS52940.1"
                     /db_xref="GeneID:19228"
                     /db_xref="MGI:MGI:97801"
ORIGIN      
        1 mgtariapsl alllccpvls sayalvdadd vftkeeqifl lhraqaqcdk llkevlhtaa
       61 nimesdkgwt pastsgkprk ekapgkfype skenkdvptg srrrgrpclp ewdnivcwpl
      121 gapgevvavp cpdyiydfnh kghayrrcdr ngswevvpgh nrtwanysec lkfmtnetre
      181 revfdrlgmi ytvgysmsla sltvavlila yfrrlhctrn yihmhmflsf mlraasifvk
      241 davlysgftl deaerlteee lhiiaqvppp paaaavgyag crvavtffly flatnyywil
      301 veglylhsli fmaffsekky lwgftifgwg lpavfvavwv gvratlantg cwdlssghkk
      361 wiiqvpilas vvlnfilfin iirvlatklr etnagrcdtr qqyrkllrst lvlvplfgvh
      421 ytvfmalpyt evsgtlwqiq mhyemlfnsf qgffvaiiyc fcngevqaei rkswsrwtla
      481 ldfkrkarsg sssysygpmv shtsvtnvgp raglslplsp rllpattngh sqlpghakpg
      541 apaienetip vtmtvpkddg flngscsgld eeasgsarpp pllqeewetv m
//
LOCUS       NP_619610                411 aa            linear   ROD 09-OCT-2023
DEFINITION  eukaryotic initiation factor 4A-III [Mus musculus].
ACCESSION   NP_619610
VERSION     NP_619610.1
DBSOURCE    REFSEQ: accession NM_138669.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 411)
  AUTHORS   Yang Y, Yang H and Yang C.
  TITLE     Circ-AMOTL1 enhances cardiac fibrosis through binding with EIF4A3
            and stabilizing MARCKS expression in diabetic cardiomyopathy
  JOURNAL   Cell Signal 111, 110853 (2023)
   PUBMED   37586467
  REMARK    GeneRIF: Circ-AMOTL1 enhances cardiac fibrosis through binding with
            EIF4A3 and stabilizing MARCKS expression in diabetic
            cardiomyopathy.
REFERENCE   2  (residues 1 to 411)
  AUTHORS   Luo P, Gong Y, Weng J, Wen F, Luo J, Hu C, Xiao J and Shu J.
  TITLE     CircKIF4A combines EIF4A3 to stabilize SDC1 expression to activate
            c-src/FAK and promotes TNBC progression
  JOURNAL   Cell Signal 108, 110690 (2023)
   PUBMED   37121557
  REMARK    GeneRIF: CircKIF4A combines EIF4A3 to stabilize SDC1 expression to
            activate c-src/FAK and promotes TNBC progression.
REFERENCE   3  (residues 1 to 411)
  AUTHORS   Lupan BM, Solecki RA, Musso CM, Alsina FC and Silver DL.
  TITLE     The exon junction complex component EIF4A3 is essential for mouse
            and human cortical progenitor mitosis and neurogenesis
  JOURNAL   Development 150 (10) (2023)
   PUBMED   37139782
  REMARK    GeneRIF: The exon junction complex component EIF4A3 is essential
            for mouse and human cortical progenitor mitosis and neurogenesis.
REFERENCE   4  (residues 1 to 411)
  AUTHORS   Miller EE, Kobayashi GS, Musso CM, Allen M, Ishiy FAA, de Caires LC
            Jr, Goulart E, Griesi-Oliveira K, Zechi-Ceide RM, Richieri-Costa A,
            Bertola DR, Passos-Bueno MR and Silver DL.
  TITLE     EIF4A3 deficient human iPSCs and mouse models demonstrate neural
            crest defects that underlie Richieri-Costa-Pereira syndrome
  JOURNAL   Hum Mol Genet 26 (12), 2177-2191 (2017)
   PUBMED   28334780
REFERENCE   5  (residues 1 to 411)
  AUTHORS   Mao H, McMahon JJ, Tsai YH, Wang Z and Silver DL.
  TITLE     Haploinsufficiency for Core Exon Junction Complex Components
            Disrupts Embryonic Neurogenesis and Causes p53-Mediated
            Microcephaly
  JOURNAL   PLoS Genet 12 (9), e1006282 (2016)
   PUBMED   27618312
  REMARK    GeneRIF: we first show that Eif4a3 haploinsufficiency phenocopies
            aberrant neurogenesis and microcephaly of Magoh and Rbm8a mutant
            mice.we show that genetic ablation of one downstream pathway, p53,
            significantly rescues microcephaly of all 3 EJC mutant
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 411)
  AUTHORS   Hutchins JR, Toyoda Y, Hegemann B, Poser I, Heriche JK, Sykora MM,
            Augsburg M, Hudecz O, Buschhorn BA, Bulkescher J, Conrad C,
            Comartin D, Schleiffer A, Sarov M, Pozniakovsky A, Slabicki MM,
            Schloissnig S, Steinmacher I, Leuschner M, Ssykor A, Lawo S,
            Pelletier L, Stark H, Nasmyth K, Ellenberg J, Durbin R, Buchholz F,
            Mechtler K, Hyman AA and Peters JM.
  TITLE     Systematic analysis of human protein complexes identifies
            chromosome segregation proteins
  JOURNAL   Science 328 (5978), 593-599 (2010)
   PUBMED   20360068
REFERENCE   7  (residues 1 to 411)
  AUTHORS   Koroleva OA, Calder G, Pendle AF, Kim SH, Lewandowska D, Simpson
            CG, Jones IM, Brown JW and Shaw PJ.
  TITLE     Dynamic behavior of Arabidopsis eIF4A-III, putative core protein of
            exon junction complex: fast relocation to nucleolus and splicing
            speckles under hypoxia
  JOURNAL   Plant Cell 21 (5), 1592-1606 (2009)
   PUBMED   19435936
REFERENCE   8  (residues 1 to 411)
  AUTHORS   Feng J, Lawson MA and Melamed P.
  TITLE     A proteomic comparison of immature and mature mouse gonadotrophs
            reveals novel differentially expressed nuclear proteins that
            regulate gonadotropin gene transcription and RNA splicing
  JOURNAL   Biol Reprod 79 (3), 546-561 (2008)
   PUBMED   18480465
  REMARK    GeneRIF: The knockdown of PRPF19 or EIF4A3 decreased splicing of
            Lhb, or of both beta subunit transcripts, respectively.
REFERENCE   9  (residues 1 to 411)
  AUTHORS   Okazaki N, Kikuno R, Ohara R, Inamoto S, Koseki H, Hiraoka S, Saga
            Y, Nagase T, Ohara O and Koga H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   10 (residues 1 to 411)
  AUTHORS   Le Hir H, Gatfield D, Izaurralde E and Moore MJ.
  TITLE     The exon-exon junction complex provides a binding platform for
            factors involved in mRNA export and nonsense-mediated mRNA decay
  JOURNAL   EMBO J 20 (17), 4987-4997 (2001)
   PUBMED   11532962
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC008132.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC008132.1, AK167107.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..411
                     /organism="Mus musculus"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 83.35 cM"
     Protein         1..411
                     /product="eukaryotic initiation factor 4A-III"
                     /EC_number="3.6.4.13"
                     /note="DEAD (Asp-Glu-Ala-Asp) box polypeptide 48; DEAD box
                     protein 48; ATP-dependent RNA helicase DDX48;
                     ATP-dependent RNA helicase eIF4A-3; eIF-4A-III"
                     /calculated_mol_wt=46709
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:P38919; propagated from
                     UniProtKB/Swiss-Prot (Q91VC3.3)"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine, in Eukaryotic initiation factor
                     4A-III, N-terminally processed.
                     /evidence=ECO:0000250|UniProtKB:P38919; propagated from
                     UniProtKB/Swiss-Prot (Q91VC3.3)"
     Site            10
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P60842; propagated from
                     UniProtKB/Swiss-Prot (Q91VC3.3)"
     Site            12
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P38919; propagated from
                     UniProtKB/Swiss-Prot (Q91VC3.3)"
     Region          35..411
                     /region_name="DEAD-like_helicase_N"
                     /note="N-terminal helicase domain of the DEAD-box helicase
                     superfamily; cl28899"
                     /db_xref="CDD:452890"
     Region          38..66
                     /region_name="Q motif"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91VC3.3)"
     Site            order(40,56,58..62,65,83..90,187..188)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:350803"
     Site            order(63,67,83,86,222..224,227)
                     /site_type="other"
                     /note="Mago interface [polypeptide binding]"
                     /db_xref="CDD:350803"
     Site            order(106,150..151,154..155,174,177..179,201..202,
                     205..210,230..234)
                     /site_type="other"
                     /note="Barentsz interface [polypeptide binding]"
                     /db_xref="CDD:350803"
     Site            order(114..116,142..143,163..166,169,172,197,200)
                     /site_type="other"
                     /note="RNA binding site [nucleotide binding]"
                     /db_xref="CDD:350803"
     Site            124
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P60842; propagated from
                     UniProtKB/Swiss-Prot (Q91VC3.3)"
     Site            163
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P38919; propagated from
                     UniProtKB/Swiss-Prot (Q91VC3.3)"
     Region          187..190
                     /region_name="DEAD box. /evidence=ECO:0000305"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91VC3.3)"
     Site            198
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P60843; propagated from
                     UniProtKB/Swiss-Prot (Q91VC3.3)"
     Site            296
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P38919; propagated from
                     UniProtKB/Swiss-Prot (Q91VC3.3)"
     Site            321
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P38919; propagated from
                     UniProtKB/Swiss-Prot (Q91VC3.3)"
     CDS             1..411
                     /gene="Eif4a3"
                     /gene_synonym="2400003O03Rik; Ddx48; eIF4A-III; mKIAA0111"
                     /coded_by="NM_138669.1:48..1283"
                     /db_xref="CCDS:CCDS25714.1"
                     /db_xref="GeneID:192170"
                     /db_xref="MGI:MGI:1923731"
ORIGIN      
        1 maanatmats gsarkrllke edmtkvefet seevdvtptf dtmglredll rgiyaygfek
       61 psaiqqraik qiikgrdvia qsqsgtgkta tfsvsvlqcl diqvretqal ilaptrelav
      121 qiqkgllalg dymnvqchac iggtnvgedi rkldygqhvv agtpgrvfdm irrrslrtra
      181 ikmlvldead emlnkgfkeq iydvyrylpp atqvvlisat lpheilemtn kfmtdpiril
      241 vkrdeltleg ikqffvaver eewkfdtlcd lydtltitqa vifcntkrkv dwltekmrea
      301 nftvssmhgd mpqkeresim kefrsgasrv listdvwarg ldvpqvslii nydlpnnrel
      361 yihrigrsgr ygrkgvainf vknddirilr dieqyystqi dempmnvadl i
//
LOCUS       NP_033909                477 aa            linear   ROD 09-OCT-2023
DEFINITION  C3a anaphylatoxin chemotactic receptor [Mus musculus].
ACCESSION   NP_033909
VERSION     NP_033909.1
DBSOURCE    REFSEQ: accession NM_009779.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 477)
  AUTHORS   Gedam M, Comerota MM, Propson NE, Chen T, Jin F, Wang MC and Zheng
            H.
  TITLE     Complement C3aR depletion reverses HIF-1alpha-induced metabolic
            impairment and enhances microglial response to Abeta pathology
  JOURNAL   J Clin Invest 133 (12), e167501 (2023)
   PUBMED   37317973
  REMARK    GeneRIF: Complement C3aR depletion reverses HIF-1alpha-induced
            metabolic impairment and enhances microglial response to Abeta
            pathology.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 477)
  AUTHORS   Kong LR, Chen XH, Sun Q, Zhang KY, Xu L, Ding L, Zhou YP, Zhang ZB,
            Lin JR and Gao PJ.
  TITLE     Loss of C3a and C5a receptors promotes adipocyte browning and
            attenuates diet-induced obesity via activating inosine/A2aR pathway
  JOURNAL   Cell Rep 42 (2), 112078 (2023)
   PUBMED   36735535
  REMARK    GeneRIF: Loss of C3a and C5a receptors promotes adipocyte browning
            and attenuates diet-induced obesity via activating inosine/A2aR
            pathway.
REFERENCE   3  (residues 1 to 477)
  AUTHORS   Cumpelik A, Cody E, Yu SM, Grasset EK, Dominguez-Sola D, Cerutti A
            and Heeger PS.
  TITLE     Cutting Edge: Neutrophil Complement Receptor Signaling Is Required
            for BAFF-Dependent Humoral Responses in Mice
  JOURNAL   J Immunol 210 (1), 19-23 (2023)
   PUBMED   36454023
REFERENCE   4  (residues 1 to 477)
  AUTHORS   Zhao SJ, Wu KY, Min XY, Wang CX, Cao B, Ma N, Yang XL, Zhu ZR, Fu
            RG, Zhou W, Yang JR and Li K.
  TITLE     Protective role for C3aR in experimental chronic pyelonephritis
  JOURNAL   FASEB J 36 (11), e22599 (2022)
   PUBMED   36250902
  REMARK    GeneRIF: Protective role for C3aR in experimental chronic
            pyelonephritis.
REFERENCE   5  (residues 1 to 477)
  AUTHORS   Cohen A, Jeng EE, Voorhies M, Symington J, Ali N, Rodriguez RA,
            Bassik MC and Sil A.
  TITLE     Genome-scale CRISPR screening reveals that C3aR signaling is
            critical for rapid capture of fungi by macrophages
  JOURNAL   PLoS Pathog 18 (9), e1010237 (2022)
   PUBMED   36174103
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 477)
  AUTHORS   Humbles AA, Lu B, Nilsson CA, Lilly C, Israel E, Fujiwara Y, Gerard
            NP and Gerard C.
  TITLE     A role for the C3a anaphylatoxin receptor in the effector phase of
            asthma
  JOURNAL   Nature 406 (6799), 998-1001 (2000)
   PUBMED   10984054
REFERENCE   7  (residues 1 to 477)
  AUTHORS   Lawson PR and Reid KB.
  TITLE     A novel PCR-based technique using expressed sequence tags and gene
            homology for murine genetic mapping: localization of the complement
            genes
  JOURNAL   Int Immunol 12 (3), 231-240 (2000)
   PUBMED   10700458
REFERENCE   8  (residues 1 to 477)
  AUTHORS   Hollmann TJ, Haviland DL, Kildsgaard J, Watts K and Wetsel RA.
  TITLE     Cloning, expression, sequence determination, and chromosome
            localization of the mouse complement C3a anaphylatoxin receptor
            gene
  JOURNAL   Mol Immunol 35 (3), 137-148 (1998)
   PUBMED   9694514
REFERENCE   9  (residues 1 to 477)
  AUTHORS   Tornetta MA, Foley JJ, Sarau HM and Ames RS.
  TITLE     The mouse anaphylatoxin C3a receptor: molecular cloning, genomic
            organization, and functional expression
  JOURNAL   J Immunol 158 (11), 5277-5282 (1997)
   PUBMED   9164946
REFERENCE   10 (residues 1 to 477)
  AUTHORS   Hsu MH, Ember JA, Wang M, Prossnitz ER, Hugli TE and Ye RD.
  TITLE     Cloning and functional characterization of the mouse C3a
            anaphylatoxin receptor gene
  JOURNAL   Immunogenetics 47 (1), 64-72 (1997)
   PUBMED   9382922
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB665738.1, U77460.1 and AK080984.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BB665738.1, U77460.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 57.93 cM"
     Protein         1..477
                     /product="C3a anaphylatoxin chemotactic receptor"
                     /note="C3a-R; anaphylatoxin C3a receptor"
                     /calculated_mol_wt=53445
     Site            9
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O09047.1)"
     Site            24..46
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O09047.1)"
     Region          46..439
                     /region_name="7tm_GPCRs"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; cl28897"
                     /db_xref="CDD:452889"
     Site            58..80
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O09047.1)"
     Region          58..79
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:410628"
     Region          96..118
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:410628"
     Site            97..118
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O09047.1)"
     Site            140..160
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O09047.1)"
     Region          141..157
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:410628"
     Site            168
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O09047.1)"
     Site            174
                     /site_type="sulfatation"
                     /note="Sulfotyrosine. /evidence=ECO:0000250; propagated
                     from UniProtKB/Swiss-Prot (O09047.1)"
     Site            184
                     /site_type="sulfatation"
                     /note="Sulfotyrosine. /evidence=ECO:0000250; propagated
                     from UniProtKB/Swiss-Prot (O09047.1)"
     Site            197
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O09047.1)"
     Site            201
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O09047.1)"
     Site            312
                     /site_type="sulfatation"
                     /note="Sulfotyrosine. /evidence=ECO:0000250; propagated
                     from UniProtKB/Swiss-Prot (O09047.1)"
     Region          327..350
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:410628"
     Site            334..353
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O09047.1)"
     Region          369..391
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:410628"
     Site            371..393
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O09047.1)"
     Region          407..432
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:410628"
     Site            411..431
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O09047.1)"
     Site            452
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (O09047.1)"
     Site            456
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (O09047.1)"
     CDS             1..477
                     /gene="C3ar1"
                     /gene_synonym="AZ3B; C3AR; HNFAG09"
                     /coded_by="NM_009779.2:183..1616"
                     /db_xref="CCDS:CCDS20504.1"
                     /db_xref="GeneID:12267"
                     /db_xref="MGI:MGI:1097680"
ORIGIN      
        1 mesfdadtns tdlhsrplfq pqdiasmvil gltcllgllg nglvlwvagv kmkttvntvw
       61 flhltladfl cclslpfsla hlilqghwpy glflcklips iiilnmfasv flltaisldr
      121 clivhkpiwc qnhrnvrtaf aicgcvwvva fvmcvpvfvy rdlfimdnrs icrynfdssr
      181 sydywdyvyk lslpesnstd nstaqltghm ndrsapssvq ardyfwtvtt alqsqpflts
      241 pedsfsldsa nqqphyggkp pnvltaavps gfpvedrksn tlnadaflsa htelfptass
      301 ghlypydfqg dyvdqftydn hvptplmait itrlvvgflv pffimvicys livfrmrktn
      361 ftksrnktfr vavavvtvff icwtpyhlvg vlllitdpes slgeavmswd hmsialasan
      421 scfnpflyal lgkdfrkkar qsikgileaa fseelthstn ctqdkasskr nnmstdv
//
LOCUS       NP_001342086             280 aa            linear   ROD 09-OCT-2023
DEFINITION  F-box only protein 27 isoform 1 [Mus musculus].
ACCESSION   NP_001342086 XP_006539929
VERSION     NP_001342086.1
DBSOURCE    REFSEQ: accession NM_001355157.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 280)
  AUTHORS   Liu D, Xing R, Zhang Q, Tian X, Qi Y, Song H, Liu Y, Yu H, Zhang X,
            Jing Q, Yan C and Han Y.
  TITLE     The CREG1-FBXO27-LAMP2 axis alleviates diabetic cardiomyopathy by
            promoting autophagy in cardiomyocytes
  JOURNAL   Exp Mol Med 55 (9), 2025-2038 (2023)
   PUBMED   37658156
  REMARK    GeneRIF: The CREG1-FBXO27-LAMP2 axis alleviates diabetic
            cardiomyopathy by promoting autophagy in cardiomyocytes.
REFERENCE   2  (residues 1 to 280)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC109162.12.
            
            On Sep 9, 2017 this sequence version replaced XP_006539929.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.1428375.1,
                                           ERR3363660.470314.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..280
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 16.89 cM"
     Protein         1..280
                     /product="F-box only protein 27 isoform 1"
                     /note="F-box only protein 27"
                     /calculated_mol_wt=31502
     Region          <37..70
                     /region_name="F-box_SF"
                     /note="F-box domain superfamily; cl45894"
                     /db_xref="CDD:459239"
     Region          102..275
                     /region_name="FBA"
                     /note="F-box associated region; pfam04300"
                     /db_xref="CDD:427850"
     CDS             1..280
                     /gene="Fbxo27"
                     /gene_synonym="E130008B10Rik; FBG5; Gm161"
                     /coded_by="NM_001355157.1:84..926"
                     /note="isoform 1 is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS52164.1"
                     /db_xref="GeneID:233040"
                     /db_xref="MGI:MGI:2685007"
ORIGIN      
        1 mgawisrtrv ptpepdpqev ldlsrlppel lllvlshvpp rtllmhcrrv crawralvdg
       61 qalwllllar dhsaagrall tlarrclppa hedtpcplgq fcalrplgrn lisnpcgqeg
      121 lrkwmvrhgg dgwvveknrk pvpgapsqtc fvtsfswcrk kqvvdlvekg lwpelldsgg
      181 veiavsdwwg arhdsgckyr lfvtlldahq nvidkfsavp dpieqwnndi ylqvthvfsg
      241 irrgirfvsf ehwgqdtqfw aghygarvtn ssviirvcqs
//
LOCUS       NP_062801                420 aa            linear   ROD 09-OCT-2023
DEFINITION  glycogen synthase kinase-3 beta isoform 1 [Mus musculus].
ACCESSION   NP_062801 XP_358795
VERSION     NP_062801.1
DBSOURCE    REFSEQ: accession NM_019827.7
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 420)
  AUTHORS   Fu Y, Wang J, Liu C, Liao K, Gao X, Tang R, Fan B, Hong Y, Xiao N,
            Xiao C and Liu WH.
  TITLE     Glycogen synthase kinase 3 controls T-cell exhaustion by regulating
            NFAT activation
  JOURNAL   Cell Mol Immunol 20 (10), 1127-1139 (2023)
   PUBMED   37553428
  REMARK    GeneRIF: Glycogen synthase kinase 3 controls T-cell exhaustion by
            regulating NFAT activation.
REFERENCE   2  (residues 1 to 420)
  AUTHORS   Brishti MA, Raghavan S, Lamar K, Singh UP, Collier DM and Leo MD.
  TITLE     Diabetic Endothelial Cell Glycogen Synthase Kinase 3beta Activation
            Induces VCAM1 Ectodomain Shedding
  JOURNAL   Int J Mol Sci 24 (18), 14105 (2023)
   PUBMED   37762417
  REMARK    GeneRIF: Diabetic Endothelial Cell Glycogen Synthase Kinase 3beta
            Activation Induces VCAM1 Ectodomain Shedding.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 420)
  AUTHORS   Sunilkumar S, VanCleave AM, McCurry CM, Toro AL, Stevens SA,
            Kimball SR and Dennis MD.
  TITLE     REDD1-dependent GSK3beta dephosphorylation promotes NF-kappaB
            activation and macrophage infiltration in the retina of diabetic
            mice
  JOURNAL   J Biol Chem 299 (8), 104991 (2023)
   PUBMED   37392853
  REMARK    GeneRIF: REDD1-dependent GSK3beta dephosphorylation promotes
            NF-kappaB activation and macrophage infiltration in the retina of
            diabetic mice.
REFERENCE   4  (residues 1 to 420)
  AUTHORS   Cai X, Zhao Y, Yang Y, Wu X, Zhang L, Ma JA, Ji J, Bostrom KI and
            Yao Y.
  TITLE     GSK3beta Inhibition Ameliorates Atherosclerotic Calcification
  JOURNAL   Int J Mol Sci 24 (14), 11638 (2023)
   PUBMED   37511396
  REMARK    GeneRIF: GSK3beta Inhibition Ameliorates Atherosclerotic
            Calcification.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 420)
  AUTHORS   Sun L, Zhang X, Wu S, Liu Y, Guerrero-Juarez CF, Liu W, Huang J,
            Yao Q, Yin M, Li J, Ramos R, Liao Y, Wu R, Xia T, Zhang X, Yang Y,
            Li F, Heng S, Zhang W, Yang M, Tzeng CM, Ji C, Plikus MV, Gallo RL
            and Zhang LJ.
  TITLE     Dynamic interplay between IL-1 and WNT pathways in regulating
            dermal adipocyte lineage cells during skin development and wound
            regeneration
  JOURNAL   Cell Rep 42 (6), 112647 (2023)
   PUBMED   37330908
REFERENCE   6  (residues 1 to 420)
  AUTHORS   Sakanaka C and Williams LT.
  TITLE     Functional domains of axin. Importance of the C terminus as an
            oligomerization domain
  JOURNAL   J Biol Chem 274 (20), 14090-14093 (1999)
   PUBMED   10318824
REFERENCE   7  (residues 1 to 420)
  AUTHORS   Diehl JA, Cheng M, Roussel MF and Sherr CJ.
  TITLE     Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and
            subcellular localization
  JOURNAL   Genes Dev 12 (22), 3499-3511 (1998)
   PUBMED   9832503
REFERENCE   8  (residues 1 to 420)
  AUTHORS   Hart MJ, de los Santos R, Albert IN, Rubinfeld B and Polakis P.
  TITLE     Downregulation of beta-catenin by human Axin and its association
            with the APC tumor suppressor, beta-catenin and GSK3 beta
  JOURNAL   Curr Biol 8 (10), 573-581 (1998)
   PUBMED   9601641
REFERENCE   9  (residues 1 to 420)
  AUTHORS   Behrens J, Jerchow BA, Wurtele M, Grimm J, Asbrand C, Wirtz R, Kuhl
            M, Wedlich D and Birchmeier W.
  TITLE     Functional interaction of an axin homolog, conductin, with
            beta-catenin, APC, and GSK3beta
  JOURNAL   Science 280 (5363), 596-599 (1998)
   PUBMED   9554852
REFERENCE   10 (residues 1 to 420)
  AUTHORS   Cohen,J.S.
  TITLE     Provide fluoxetine information vital to clinicians
  JOURNAL   J Clin Psychiatry 56 (12), 591 (1995)
   PUBMED   8530339
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC120020.9 and AC154284.1.
            
            On Dec 17, 2003 this sequence version replaced XP_358795.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB066114.1, AK154293.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..420
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 26.54 cM"
     Protein         1..420
                     /product="glycogen synthase kinase-3 beta isoform 1"
                     /EC_number="2.7.11.1"
                     /EC_number="2.7.11.26"
                     /note="serine/threonine-protein kinase GSK3B"
                     /calculated_mol_wt=46579
     Region          1..53
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WV60.2)"
     Site            9
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKB/AKT1, RPS6KA3 and SGK3.
                     /evidence=ECO:0000269|PubMed:22057101,
                     ECO:0000269|PubMed:23395175, ECO:0000269|PubMed:27827363;
                     propagated from UniProtKB/Swiss-Prot (Q9WV60.2)"
     Region          51..343
                     /region_name="STKc_GSK3"
                     /note="The catalytic domain of the Serine/Threonine
                     Kinase, Glycogen Synthase Kinase 3; cd14137"
                     /db_xref="CDD:271039"
     Site            order(62..66,70,83,85,96,110,132..135,138,140..141,181,
                     183,185..186,188,200,203,214,216..219,221,259)
                     /site_type="active"
                     /db_xref="CDD:271039"
     Site            order(62..65,70,83,85,110,132..135,138,183,185..186,188,
                     200)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271039"
     Site            order(66..67,212..220,228..229,260..264,266..267,271,
                     291..294)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:271039"
     Site            order(96,140,181,183,203,214,216..219,221,259)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:271039"
     Site            order(199..209,211..221)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:271039"
     Site            216
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P49841; propagated from
                     UniProtKB/Swiss-Prot (Q9WV60.2)"
     Site            order(228,263..264,266..267,270..271,291..296)
                     /site_type="other"
                     /note="axin binding site [polypeptide binding]"
                     /db_xref="CDD:271039"
     Region          385..420
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WV60.2)"
     Site            389
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:15345747; propagated from
                     UniProtKB/Swiss-Prot (Q9WV60.2)"
     CDS             1..420
                     /gene="Gsk3b"
                     /gene_synonym="7330414F15Rik; 8430431H08Rik; GSK-3;
                     GSK-3beta; GSK3"
                     /coded_by="NM_019827.7:1526..2788"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS28163.1"
                     /db_xref="GeneID:56637"
                     /db_xref="MGI:MGI:1861437"
ORIGIN      
        1 msgrprttsf aesckpvqqp safgsmkvsr dkdgskvttv vatpgqgpdr pqevsytdtk
       61 vigngsfgvv yqaklcdsge lvaikkvlqd krfknrelqi mrkldhcniv rlryffyssg
      121 ekkdevylnl vldyvpetvy rvarhysrak qtlpviyvkl ymyqlfrsla yihsfgichr
      181 dikpqnllld pdtavlklcd fgsakqlvrg epnvsyicsr yyrapelifg atdytssidv
      241 wsagcvlael llgqpifpgd sgvdqlveii kvlgtptreq iremnpnyte fkfpqikahp
      301 wtkvfrprtp peaialcsrl leytptarlt pleacahsff delrdpnvkl pngrdtpalf
      361 nfttqelssn pplatilipp hariqaaasp panataasdt nagdrgqtnn aasasasnst
//
LOCUS       NP_001349213             533 aa            linear   ROD 09-OCT-2023
DEFINITION  CUGBP Elav-like family member 4 isoform 10 [Mus musculus].
ACCESSION   NP_001349213 XP_017173278
VERSION     NP_001349213.1
DBSOURCE    REFSEQ: accession NM_001362284.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 533)
  AUTHORS   Salamon I, Park Y, Miskic T, Kopic J, Matteson P, Page NF, Roque A,
            McAuliffe GW, Favate J, Garcia-Forn M, Shah P, Judas M, Millonig
            JH, Kostovic I, De Rubeis S, Hart RP, Krsnik Z and Rasin MR.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    GeneRIF: Celf4 controls mRNA translation underlying synaptic
            development in the prenatal mammalian neocortex.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 533)
  AUTHORS   Shen Y, Zhang C, Xiao K, Liu D and Xie G.
  TITLE     CELF4 regulates spine formation and depression-like behaviors of
            mice
  JOURNAL   Biochem Biophys Res Commun 605, 39-44 (2022)
   PUBMED   35306363
  REMARK    GeneRIF: CELF4 regulates spine formation and depression-like
            behaviors of mice.
REFERENCE   3  (residues 1 to 533)
  AUTHORS   Moreau MX, Saillour Y, Cwetsch AW, Pierani A and Causeret F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   4  (residues 1 to 533)
  AUTHORS   Li C, Li X, Bi Z, Sugino K, Wang G, Zhu T and Liu Z.
  TITLE     Comprehensive transcriptome analysis of cochlear spiral ganglion
            neurons at multiple ages
  JOURNAL   Elife 9, e50491 (2020)
   PUBMED   31913118
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 533)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 533)
  AUTHORS   Ladd AN, Taffet G, Hartley C, Kearney DL and Cooper TA.
  TITLE     Cardiac tissue-specific repression of CELF activity disrupts
            alternative splicing and causes cardiomyopathy
  JOURNAL   Mol Cell Biol 25 (14), 6267-6278 (2005)
   PUBMED   15988035
  REMARK    GeneRIF: CELF protein activity is required for normal alternative
            splicing in the heart in vivo and normal CELF-mediated alternative
            splicing regulation is in turn required for normal cardiac
            function.
REFERENCE   7  (residues 1 to 533)
  AUTHORS   Meins M, Schlickum S, Wilhelm C, Missbach J, Yadav S, Glaser B,
            Grzmil M, Burfeind P and Laccone F.
  TITLE     Identification and characterization of murine Brunol4, a new member
            of the elav/bruno family
  JOURNAL   Cytogenet Genome Res 97 (3-4), 254-260 (2002)
   PUBMED   12438720
  REMARK    GeneRIF: cloning and characterization
REFERENCE   8  (residues 1 to 533)
  AUTHORS   Ladd AN, Charlet N and Cooper TA.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   9  (residues 1 to 533)
  AUTHORS   Good PJ, Chen Q, Warner SJ and Herring DC.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
REFERENCE   10 (residues 1 to 533)
  AUTHORS   Yulug IG, Egan SE, See CG and Fisher EM.
  TITLE     Mapping GRB2, a signal transduction gene in the human and the mouse
  JOURNAL   Genomics 22 (2), 313-318 (1994)
   PUBMED   7806216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121094.8 and AC144938.3.
            
            On Apr 12, 2018 this sequence version replaced XP_017173278.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.205175.1,
                                           SRR7345562.1523646.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..533
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 13.92 cM"
     Protein         1..533
                     /product="CUGBP Elav-like family member 4 isoform 10"
                     /note="CUG-BP- and ETR-3-like factor 4; bruno-like protein
                     4; RNA-binding protein BRUNOL-4; bruno-like 4, RNA binding
                     protein"
                     /calculated_mol_wt=56727
     Region          49..135
                     /region_name="RRM1_CELF3_4_5_6"
                     /note="RNA recognition motif 1 (RRM1) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12632"
                     /db_xref="CDD:410041"
     Site            order(55,57,59..60,63,82,84,86,95..97,99,129,131)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410041"
     Region          140..220
                     /region_name="RRM2_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12635"
                     /db_xref="CDD:410043"
     Site            order(142,144,146..147,150,169,171,173,181..183,185,215,
                     217)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410043"
     Region          405..>433
                     /region_name="RRM_SF"
                     /note="RNA recognition motif (RRM) superfamily; cl17169"
                     /db_xref="CDD:450164"
     CDS             1..533
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /coded_by="NM_001362284.1:531..2132"
                     /note="isoform 10 is encoded by transcript variant 16"
                     /db_xref="GeneID:108013"
                     /db_xref="MGI:MGI:1932407"
ORIGIN      
        1 myikmatlan gqadnaslst nglgsspgsa ghmnglshsp gnpstipmkd hdaiklfigq
       61 iprnldekdl kplfeefgki yeltvlkdrf tgmhkgcafl tyceresalk aqsalheqkt
      121 lpgmnrpiqv kpadsesrgd rklfvgmlnk qqseddvrrl feafgnieec tilrgpdgns
      181 kgcafvkyss haeaqaaina lhgsqtmpga ssslvvkfad tdkertmrrm qqmagqmgmf
      241 npmaipfgay gayaqalmqq qaalmasvaq ggylnpmaaf aaaqmqqmaa lnmnglaaap
      301 mtptsggstp pgitapavps ipspigvngf tglppqangq paaeavfang ihpypaqspt
      361 aadplqqaya gvqqyagpay paaygqisqa fpqpppmipq qqregpegcn lliyhlpqef
      421 gdaelmqmfl pfgrhpvpsr cqapscqggq caisssarrl relrqpgqrt drhpgherlp
      481 drheeaqgaa eaaqrrqspv lsaggsvprg rpglaqgqsn ppqsraelgi kft
//
LOCUS       NP_001349228             504 aa            linear   ROD 09-OCT-2023
DEFINITION  CUGBP Elav-like family member 4 isoform 23 [Mus musculus].
ACCESSION   NP_001349228
VERSION     NP_001349228.1
DBSOURCE    REFSEQ: accession NM_001362299.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 504)
  AUTHORS   Salamon I, Park Y, Miskic T, Kopic J, Matteson P, Page NF, Roque A,
            McAuliffe GW, Favate J, Garcia-Forn M, Shah P, Judas M, Millonig
            JH, Kostovic I, De Rubeis S, Hart RP, Krsnik Z and Rasin MR.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    GeneRIF: Celf4 controls mRNA translation underlying synaptic
            development in the prenatal mammalian neocortex.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 504)
  AUTHORS   Shen Y, Zhang C, Xiao K, Liu D and Xie G.
  TITLE     CELF4 regulates spine formation and depression-like behaviors of
            mice
  JOURNAL   Biochem Biophys Res Commun 605, 39-44 (2022)
   PUBMED   35306363
  REMARK    GeneRIF: CELF4 regulates spine formation and depression-like
            behaviors of mice.
REFERENCE   3  (residues 1 to 504)
  AUTHORS   Moreau MX, Saillour Y, Cwetsch AW, Pierani A and Causeret F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   4  (residues 1 to 504)
  AUTHORS   Li C, Li X, Bi Z, Sugino K, Wang G, Zhu T and Liu Z.
  TITLE     Comprehensive transcriptome analysis of cochlear spiral ganglion
            neurons at multiple ages
  JOURNAL   Elife 9, e50491 (2020)
   PUBMED   31913118
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 504)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 504)
  AUTHORS   Ladd AN, Taffet G, Hartley C, Kearney DL and Cooper TA.
  TITLE     Cardiac tissue-specific repression of CELF activity disrupts
            alternative splicing and causes cardiomyopathy
  JOURNAL   Mol Cell Biol 25 (14), 6267-6278 (2005)
   PUBMED   15988035
  REMARK    GeneRIF: CELF protein activity is required for normal alternative
            splicing in the heart in vivo and normal CELF-mediated alternative
            splicing regulation is in turn required for normal cardiac
            function.
REFERENCE   7  (residues 1 to 504)
  AUTHORS   Meins M, Schlickum S, Wilhelm C, Missbach J, Yadav S, Glaser B,
            Grzmil M, Burfeind P and Laccone F.
  TITLE     Identification and characterization of murine Brunol4, a new member
            of the elav/bruno family
  JOURNAL   Cytogenet Genome Res 97 (3-4), 254-260 (2002)
   PUBMED   12438720
  REMARK    GeneRIF: cloning and characterization
REFERENCE   8  (residues 1 to 504)
  AUTHORS   Ladd AN, Charlet N and Cooper TA.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   9  (residues 1 to 504)
  AUTHORS   Good PJ, Chen Q, Warner SJ and Herring DC.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
REFERENCE   10 (residues 1 to 504)
  AUTHORS   Yulug IG, Egan SE, See CG and Fisher EM.
  TITLE     Mapping GRB2, a signal transduction gene in the human and the mouse
  JOURNAL   Genomics 22 (2), 313-318 (1994)
   PUBMED   7806216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121094.8 and AC144938.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.60217.1,
                                           SRR1660819.115783.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..504
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 13.92 cM"
     Protein         1..504
                     /product="CUGBP Elav-like family member 4 isoform 23"
                     /note="CUG-BP- and ETR-3-like factor 4; bruno-like protein
                     4; RNA-binding protein BRUNOL-4; bruno-like 4, RNA binding
                     protein"
                     /calculated_mol_wt=53800
     Region          49..135
                     /region_name="RRM1_CELF3_4_5_6"
                     /note="RNA recognition motif 1 (RRM1) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12632"
                     /db_xref="CDD:410041"
     Site            order(55,57,59..60,63,82,84,86,95..97,99,129,131)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410041"
     Region          151..231
                     /region_name="RRM2_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12635"
                     /db_xref="CDD:410043"
     Site            order(153,155,157..158,161,180,182,184,192..194,196,226,
                     228)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410043"
     Region          415..493
                     /region_name="RRM3_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12639"
                     /db_xref="CDD:241083"
     CDS             1..504
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /coded_by="NM_001362299.1:531..2045"
                     /note="isoform 23 is encoded by transcript variant 28"
                     /db_xref="GeneID:108013"
                     /db_xref="MGI:MGI:1932407"
ORIGIN      
        1 myikmatlan gqadnaslst nglgsspgsa ghmnglshsp gnpstipmkd hdaiklfigq
       61 iprnldekdl kplfeefgki yeltvlkdrf tgmhkgcafl tyceresalk aqsalheqkt
      121 lpgmnrpiqv kpadsesrgg ssclrqppsq drklfvgmln kqqseddvrr lfeafgniee
      181 ctilrgpdgn skgcafvkys shaeaqaain alhgsqtmpg assslvvkfa dtdkertmrr
      241 mqqmagqmgm fnpmaipfga ygayaqamqq qaalmasvaq ggylnpmaaf aaaqmqqmaa
      301 lnmnglaaap mtptsggstp pgitapavps ipspigvngf tglppqangq paaeavfang
      361 ihpypaqspt aadplqqaya gvqqyagpay paaygqisqa fpqpppmipq qqregpegcn
      421 lliyhlpqef gdaelmqmfl pfgnvisskv fvdratnqsk cfgfvsfdnp asaqtaiqam
      481 ngfqigmkrl kvqlkrpkda nrpy
//
LOCUS       NP_001193312             333 aa            linear   ROD 09-OCT-2023
DEFINITION  mitochondrial antiviral-signaling protein isoform 2 [Mus musculus].
ACCESSION   NP_001193312
VERSION     NP_001193312.1
DBSOURCE    REFSEQ: accession NM_001206383.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 333)
  AUTHORS   Liu F, Zhuang W, Song B, Yang Y, Liu J, Zheng Y, Liu B, Zheng J,
            Zhao W and Gao C.
  TITLE     MAVS-loaded unanchored Lys63-linked polyubiquitin chains activate
            the RIG-I-MAVS signaling cascade
  JOURNAL   Cell Mol Immunol 20 (10), 1186-1202 (2023)
   PUBMED   37582970
  REMARK    GeneRIF: MAVS-loaded unanchored Lys63-linked polyubiquitin chains
            activate the RIG-I-MAVS signaling cascade.
REFERENCE   2  (residues 1 to 333)
  AUTHORS   Ingle H, Makimaa H, Aggarwal S, Deng H, Foster L, Li Y, Kennedy EA,
            Peterson ST, Wilen CB, Lee S, Suthar MS and Baldridge MT.
  TITLE     IFN-lambda derived from nonsusceptible enterocytes acts on tuft
            cells to limit persistent norovirus
  JOURNAL   Sci Adv 9 (37), eadi2562 (2023)
   PUBMED   37703370
REFERENCE   3  (residues 1 to 333)
  AUTHORS   He QQ, Huang Y, Nie L, Ren S, Xu G, Deng F, Cheng Z, Zuo Q, Zhang
            L, Cai H, Wang Q, Wang F, Ren H, Yan H, Xu K, Zhou L, Lu M, Lu Z,
            Zhu Y and Liu S.
  TITLE     MAVS integrates glucose metabolism and RIG-I-like receptor
            signaling
  JOURNAL   Nat Commun 14 (1), 5343 (2023)
   PUBMED   37660168
  REMARK    GeneRIF: MAVS integrates glucose metabolism and RIG-I-like receptor
            signaling.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 333)
  AUTHORS   Li J, Zhang R, Wang C, Zhu J, Ren M, Jiang Y, Hou X, Du Y, Wu Q, Qi
            S, Li L, Chen S, Yang H and Hou F.
  TITLE     WDR77 inhibits prion-like aggregation of MAVS to limit antiviral
            innate immune response
  JOURNAL   Nat Commun 14 (1), 4824 (2023)
   PUBMED   37563140
  REMARK    GeneRIF: WDR77 inhibits prion-like aggregation of MAVS to limit
            antiviral innate immune response.
            Erratum:[Nat Commun. 2023 Sep 25;14(1):5960. PMID: 37749076]
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 333)
  AUTHORS   Wang H, Sun W, Traba J, Wu J, Qi CF, Amo L, Kole HK, Scott B, Singh
            K, Sack MN and Bolland S.
  TITLE     MAVS Positively Regulates Mitochondrial Integrity and Metabolic
            Fitness in B Cells
  JOURNAL   Immunohorizons 7 (8), 587-599 (2023)
   PUBMED   37610299
  REMARK    GeneRIF: MAVS Positively Regulates Mitochondrial Integrity and
            Metabolic Fitness in B Cells.
REFERENCE   6  (residues 1 to 333)
  AUTHORS   Kumar H, Kawai T, Kato H, Sato S, Takahashi K, Coban C, Yamamoto M,
            Uematsu S, Ishii KJ, Takeuchi O and Akira S.
  TITLE     Essential role of IPS-1 in innate immune responses against RNA
            viruses
  JOURNAL   J Exp Med 203 (7), 1795-1803 (2006)
   PUBMED   16785313
  REMARK    GeneRIF: IPS-1 is the sole adapter in both retinoic acid-inducible
            gene (RIG-I) and melanoma differentiation-associated gene 5 (Mda5)
            signaling that mediates effective responses against a variety of
            RNA viruses.
REFERENCE   7  (residues 1 to 333)
  AUTHORS   Sun Q, Sun L, Liu HH, Chen X, Seth RB, Forman J and Chen ZJ.
  TITLE     The specific and essential role of MAVS in antiviral innate immune
            responses
  JOURNAL   Immunity 24 (5), 633-642 (2006)
   PUBMED   16713980
REFERENCE   8  (residues 1 to 333)
  AUTHORS   Meylan E, Curran J, Hofmann K, Moradpour D, Binder M,
            Bartenschlager R and Tschopp J.
  TITLE     Cardif is an adaptor protein in the RIG-I antiviral pathway and is
            targeted by hepatitis C virus
  JOURNAL   Nature 437 (7062), 1167-1172 (2005)
   PUBMED   16177806
REFERENCE   9  (residues 1 to 333)
  AUTHORS   Xu LG, Wang YY, Han KJ, Li LY, Zhai Z and Shu HB.
  TITLE     VISA is an adapter protein required for virus-triggered IFN-beta
            signaling
  JOURNAL   Mol Cell 19 (6), 727-740 (2005)
   PUBMED   16153868
  REMARK    GeneRIF: Data suggest that VISA is critically involved in both
            virus-triggered TLR3-independent and TLR3-mediated antiviral
            interferon signaling.
REFERENCE   10 (residues 1 to 333)
  AUTHORS   Seth RB, Sun L, Ea CK and Chen ZJ.
  TITLE     Identification and characterization of MAVS, a mitochondrial
            antiviral signaling protein that activates NF-kappaB and IRF 3
  JOURNAL   Cell 122 (5), 669-682 (2005)
   PUBMED   16125763
  REMARK    GeneRIF: The overexpression of mitochondrial antiviral
            signaling(MAVS)induces the expression of IFN-beta through
            activation of NF-kappaB and IRF 3, thus boosting antiviral
            immunity.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL808128.4.
            
            Transcript Variant: This variant (4) differs in the 5' UTR, lacks a
            portion of the 5' coding region and initiates translation at a
            downstream, in-frame start codon, compared to variant 1. Variants 3
            and 4 encode the same isoform (2), which has a shorter N-terminus,
            compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784646.730832.1,
                                           SRR17253014.2900316.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: PMID: 16125763; reported by
                                                  MitoCarta
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..333
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 63.3 cM"
     Protein         1..333
                     /product="mitochondrial antiviral-signaling protein
                     isoform 2"
                     /note="IFN-beta promoter stimulator-1; mitochondrial
                     anti-viral signaling protein; virus-induced signaling
                     adapter; CARD adapter inducing interferon beta; interferon
                     beta promoter stimulator protein 1"
                     /calculated_mol_wt=34258
     CDS             1..333
                     /gene="Mavs"
                     /gene_synonym="cardif; D430028G21Rik; IPS-1; Visa"
                     /coded_by="NM_001206383.1:459..1460"
                     /note="isoform 2 is encoded by transcript variant 4"
                     /db_xref="GeneID:228607"
                     /db_xref="MGI:MGI:2444773"
ORIGIN      
        1 msggslipsp nqqalspqps rehqeqepel ggahaanvas vpiatygpvs ptvsfqplpr
       61 talrtnllsg vtvsalsadt slsssstgsa fakgagdqak aatcfsttlt nsvttssvps
      121 prlvpvktms sklplsskst aamtstvltn tapsklpsns vyagtvpsrv pasvakapan
      181 tippernskq aketpegpat kvttggnqtg pnssirslhs gpemskpgvl vsqldepfsa
      241 csvdlaisps sslvsepnhg peeneyssfr iqvdespsad llgspeplat qqpqeeeehc
      301 assmpwakwl gatsallavf lavmlyrsrr laq
//
LOCUS       NP_001394502             464 aa            linear   ROD 09-OCT-2023
DEFINITION  mitogen-activated protein kinase 10 isoform 1 [Mus musculus].
ACCESSION   NP_001394502 XP_030110376
VERSION     NP_001394502.1
DBSOURCE    REFSEQ: accession NM_001407573.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 464)
  AUTHORS   Priego M, Noriega L, Kalinin S, Hoffman LM, Feinstein DL and
            Morfini G.
  TITLE     Genetic deletion of c-Jun amino-terminal kinase 3 (JNK3) modestly
            increases disease severity in a mouse model of multiple sclerosis
  JOURNAL   J Neuroimmunol 382, 578152 (2023)
   PUBMED   37454525
  REMARK    GeneRIF: Genetic deletion of c-Jun amino-terminal kinase 3 (JNK3)
            modestly increases disease severity in a mouse model of multiple
            sclerosis.
REFERENCE   2  (residues 1 to 464)
  AUTHORS   Liu F, Deng Y, Zhao Y, Li Z, Gao J, Zhang Y, Yang X, Liu Y and Xia
            Y.
  TITLE     Time series RNA-seq analysis identifies MAPK10 as a critical gene
            in diabetes mellitus-induced atrial fibrillation in mice
  JOURNAL   J Mol Cell Cardiol 168, 70-82 (2022)
   PUBMED   35489387
  REMARK    GeneRIF: Time series RNA-seq analysis identifies MAPK10 as a
            critical gene in diabetes mellitus-induced atrial fibrillation in
            mice.
REFERENCE   3  (residues 1 to 464)
  AUTHORS   Cunningham JG, Scripter JD, Nti SA and Tucker ES.
  TITLE     Early construction of the thalamocortical axon pathway requires
            c-Jun N-terminal kinase signaling within the ventral forebrain
  JOURNAL   Dev Dyn 251 (3), 459-480 (2022)
   PUBMED   34494344
REFERENCE   4  (residues 1 to 464)
  AUTHORS   Goodwani S, Fernandez C, Acton PJ, Buggia-Prevot V, McReynolds ML,
            Ma J, Hu CH, Hamby ME, Jiang Y, Le K, Soth MJ, Jones P and Ray WJ.
  TITLE     Dual Leucine Zipper Kinase Is Constitutively Active in the Adult
            Mouse Brain and Has Both Stress-Induced and Homeostatic Functions
  JOURNAL   Int J Mol Sci 21 (14), 4849 (2020)
   PUBMED   32659913
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 464)
  AUTHORS   Loughran G, Chou MY, Ivanov IP, Jungreis I, Kellis M, Kiran AM,
            Baranov PV and Atkins JF.
  TITLE     Evidence of efficient stop codon readthrough in four mammalian
            genes
  JOURNAL   Nucleic Acids Res 42 (14), 8928-8938 (2014)
   PUBMED   25013167
REFERENCE   6  (residues 1 to 464)
  AUTHORS   Beier H and Grimm M.
  TITLE     Misreading of termination codons in eukaryotes by natural nonsense
            suppressor tRNAs
  JOURNAL   Nucleic Acids Res 29 (23), 4767-4782 (2001)
   PUBMED   11726686
  REMARK    Review article
REFERENCE   7  (residues 1 to 464)
  AUTHORS   Yang DD, Kuan CY, Whitmarsh AJ, Rincon M, Zheng TS, Davis RJ, Rakic
            P and Flavell RA.
  TITLE     Absence of excitotoxicity-induced apoptosis in the hippocampus of
            mice lacking the Jnk3 gene
  JOURNAL   Nature 389 (6653), 865-870 (1997)
   PUBMED   9349820
REFERENCE   8  (residues 1 to 464)
  AUTHORS   Casanova E, Garate C, Ovalle S, Calvo P and Chinchetru MA.
  TITLE     Identification of four splice variants of the mouse
            stress-activated protein kinase JNK/SAPK alpha-isoform
  JOURNAL   Neuroreport 7 (7), 1320-1324 (1996)
   PUBMED   8817558
REFERENCE   9  (residues 1 to 464)
  AUTHORS   Martin JH, Mohit AA and Miller CA.
  TITLE     Developmental expression in the mouse nervous system of the p493F12
            SAP kinase
  JOURNAL   Brain Res Mol Brain Res 35 (1-2), 47-57 (1996)
   PUBMED   8717339
REFERENCE   10 (residues 1 to 464)
  AUTHORS   Suzuki J, Yoshida S, Chen ZL, Momota Y, Kato K, Hirata A and
            Shiosaka S.
  TITLE     Ontogeny of neuropsin mRNA expression in the mouse brain
  JOURNAL   Neurosci Res 23 (4), 345-351 (1995)
   PUBMED   8602273
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC160244.11, AC123664.15,
            AC137121.9 and AC125252.7.
            
            On Jun 6, 2022 this sequence version replaced XP_030110376.1.
            
            Summary: The protein encoded by this gene is a member of the MAP
            kinase family. MAP kinases act as integration points for multiple
            biochemical signals, and thus are involved in a wide variety of
            cellular processes, such as proliferation, differentiation,
            transcription regulation and development. This kinase is
            specifically expressed in a subset of neurons in the nervous system
            and is activated by threonine and tyrosine phosphorylation.
            Targeted deletion of this gene in mice suggests that it may have a
            role in stress-induced neuronal apoptosis. Alternatively spliced
            transcript variants encoding different isoforms have been found for
            this gene. A recent study provided evidence for translational
            readthrough in this gene, and expression of an additional
            C-terminally extended isoform via the use of an alternative
            in-frame translation termination codon. [provided by RefSeq, Dec
            2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.3686377.1,
                                           SRR14995047.2033824.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..464
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 49.61 cM"
     Protein         1..464
                     /product="mitogen-activated protein kinase 10 isoform 1"
                     /EC_number="2.7.11.24"
                     /note="JNK3 beta1 protein kinase; JNK3 beta2 protein
                     kinase; MAP kinase 10; MAP kinase p49 3F12; c-Jun
                     N-terminal kinase 3; stress-activated protein kinase JNK3;
                     SAPK/Erk/kinase 2"
                     /calculated_mol_wt=52387
     Region          63..398
                     /region_name="STKc_JNK"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     c-Jun N-terminal Kinase; cd07850"
                     /db_xref="CDD:270840"
     Site            order(70..76,78,91,93,110,124,146..152,154..155,189,191,
                     193..194,196,206..207,210,221,223..226,228,265)
                     /site_type="active"
                     /db_xref="CDD:270840"
     Site            order(70..76,78,91,93,124,146..152,196,206)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270840"
     Site            order(110,154,189,191,210,221,223..226,228,265)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270840"
     Site            order(150,156,165,168,197..201,361..362,364,367)
                     /site_type="other"
                     /note="KIM docking site [polypeptide binding]"
                     /db_xref="CDD:270840"
     Site            order(206..216,220..228)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270840"
     Region          221..223
                     /region_name="TXY"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61831.2)"
     Site            221
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by MAP2K7.
                     /evidence=ECO:0000250|UniProtKB:P53779; propagated from
                     UniProtKB/Swiss-Prot (Q61831.2)"
     Site            223
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by MAP2K4.
                     /evidence=ECO:0000250|UniProtKB:P53779; propagated from
                     UniProtKB/Swiss-Prot (Q61831.2)"
     Region          405..464
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61831.2)"
     CDS             1..464
                     /gene="Mapk10"
                     /gene_synonym="C230008H04Rik; JNK3; JNK3B1; JNK3B2;
                     p493F12; p54bSAPK; SAPK(beta); Serk2"
                     /coded_by="NM_001407573.1:810..2204"
                     /note="isoform 1 is encoded by transcript variant 8"
                     /db_xref="GeneID:26414"
                     /db_xref="MGI:MGI:1346863"
ORIGIN      
        1 mslhflyycs eptldvkiaf cqgfdkhvdv ssiakhynms kskvdnqfys vevgdstftv
       61 lkryqnlkpi gsgaqgivca aydavldrnv aikklsrpfq nqthakrayr elvlmkcvnh
      121 kniisllnvf tpqktleefq dvylvmelmd anlcqviqme ldhermsyll yqmlcgikhl
      181 hsagiihrdl kpsnivvksd ctlkildfgl artagtsfmm tpyvvtryyr apevilgmgy
      241 kenvdiwsvg cimgemvrhk ilfpgrdyid qwnkvieqlg tpcpefmkkl qptvrnyven
      301 rpkyagltfp klfpdslfpa dsehnklkas qardllskml vidpakrisv ddalqhpyin
      361 vwydpaevea pppqiydkql derehtieew keliykevmn seektkngvv kgqpspsgaa
      421 vnsseslpps ssvndissms tdqtlasdtd ssleasagpl gccr
//
LOCUS       NP_001346166             687 aa            linear   ROD 09-OCT-2023
DEFINITION  carbohydrate-responsive element-binding protein isoform 2 [Mus
            musculus].
ACCESSION   NP_001346166 XP_006504546
VERSION     NP_001346166.1
DBSOURCE    REFSEQ: accession NM_001359237.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 687)
  AUTHORS   Li L, Long J, Mise K, Poungavrin N, Lorenzi PL, Mahmud I, Tan L,
            Saha PK, Kanwar YS, Chang BH and Danesh FR.
  TITLE     The transcription factor ChREBP links mitochondrial lipidomes to
            mitochondrial morphology and progression of diabetic kidney disease
  JOURNAL   J Biol Chem 299 (9), 105185 (2023)
   PUBMED   37611830
  REMARK    GeneRIF: The transcription factor ChREBP links mitochondrial
            lipidomes to mitochondrial morphology and progression of diabetic
            kidney disease.
REFERENCE   2  (residues 1 to 687)
  AUTHORS   Sargsyan A, Doridot L, Hannou SA, Tong W, Srinivasan H, Ivison R,
            Monn R, Kou HH, Haldeman JM, Arlotto M, White PJ, Grimsrud PA,
            Astapova I, Tsai LT and Herman MA.
  TITLE     HGFAC is a ChREBP-regulated hepatokine that enhances glucose and
            lipid homeostasis
  JOURNAL   JCI Insight 8 (1), e153740 (2023)
   PUBMED   36413406
  REMARK    GeneRIF: HGFAC is a ChREBP-regulated hepatokine that enhances
            glucose and lipid homeostasis.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 687)
  AUTHORS   Seo E, Nam H and Jun HS.
  TITLE     Reactive oxygen species induce HNF-4alpha expression via the
            ASK1-CREB pathway, promoting ChREBP expression and lipogenesis in
            hepatocytes
  JOURNAL   Life Sci 310, 121042 (2022)
   PUBMED   36208661
  REMARK    GeneRIF: Reactive oxygen species induce HNF-4alpha expression via
            the ASK1-CREB pathway, promoting ChREBP expression and lipogenesis
            in hepatocytes.
REFERENCE   4  (residues 1 to 687)
  AUTHORS   Thevkar-Nagesh P, Habault J, Voisin M, Ruff SE, Ha S, Ruoff R, Chen
            X, Rawal S, Zahr T, Szabo G, Rogatsky I, Fisher EA and Garabedian
            MJ.
  TITLE     Transcriptional regulation of Acsl1 by CHREBP and NF-kappa B in
            macrophages during hyperglycemia and inflammation
  JOURNAL   PLoS One 17 (9), e0272986 (2022)
   PUBMED   36054206
  REMARK    GeneRIF: Transcriptional regulation of Acsl1 by CHREBP and NF-kappa
            B in macrophages during hyperglycemia and inflammation.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 687)
  AUTHORS   Katz LS, Brill G, Zhang P, Kumar A, Baumel-Alterzon S, Honig LB,
            Gomez-Banoy N, Karakose E, Tanase M, Doridot L, Alvarsson A,
            Davenport B, Wang P, Lambertini L, Stanley SA, Homann D, Stewart
            AF, Lo JC, Herman MA, Garcia-Ocana A and Scott DK.
  TITLE     Maladaptive positive feedback production of ChREBPbeta underlies
            glucotoxic beta-cell failure
  JOURNAL   Nat Commun 13 (1), 4423 (2022)
   PUBMED   35908073
  REMARK    Erratum:[Nat Commun. 2022 Sep 27;13(1):5681. PMID: 36167859]
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 687)
  AUTHORS   Kawaguchi T, Takenoshita M, Kabashima T and Uyeda K.
  TITLE     Glucose and cAMP regulate the L-type pyruvate kinase gene by
            phosphorylation/dephosphorylation of the carbohydrate response
            element binding protein
  JOURNAL   Proc Natl Acad Sci U S A 98 (24), 13710-13715 (2001)
   PUBMED   11698644
REFERENCE   7  (residues 1 to 687)
  AUTHORS   Cairo S, Merla G, Urbinati F, Ballabio A and Reymond A.
  TITLE     WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted
            region, is a new member of the Mlx transcription factor network
  JOURNAL   Hum Mol Genet 10 (6), 617-627 (2001)
   PUBMED   11230181
REFERENCE   8  (residues 1 to 687)
  AUTHORS   Valero MC, de Luis O, Cruces J and Perez Jurado LA.
  TITLE     Fine-scale comparative mapping of the human 7q11.23 region and the
            orthologous region on mouse chromosome 5G: the low-copy repeats
            that flank the Williams-Beuren syndrome deletion arose at
            breakpoint sites of an evolutionary inversion(s)
  JOURNAL   Genomics 69 (1), 1-13 (2000)
   PUBMED   11013070
REFERENCE   9  (residues 1 to 687)
  AUTHORS   de Luis O, Valero MC and Jurado LA.
  TITLE     WBSCR14, a putative transcription factor gene deleted in
            Williams-Beuren syndrome: complete characterisation of the human
            gene and the mouse ortholog
  JOURNAL   Eur J Hum Genet 8 (3), 215-222 (2000)
   PUBMED   10780788
REFERENCE   10 (residues 1 to 687)
  AUTHORS   Billin AN, Eilers AL, Queva C and Ayer DE.
  TITLE     Mlx, a novel Max-like BHLHZip protein that interacts with the Max
            network of transcription factors
  JOURNAL   J Biol Chem 274 (51), 36344-36350 (1999)
   PUBMED   10593926
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC084109.2 and AC024607.3.
            
            On Dec 29, 2017 this sequence version replaced XP_006504546.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            coding sequence compared to variant 1. The resulting isoform (2) is
            shorter at the N-terminus compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: JQ437838.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..687
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 75.0 cM"
     Protein         1..687
                     /product="carbohydrate-responsive element-binding protein
                     isoform 2"
                     /note="putative hepatic transcription factor; MLX
                     interactor; Williams-Beuren syndrome chromosome region 14
                     homolog; Max-like protein; carbohydrate-responsive
                     element-binding protein; MLX interacting protein-like
                     beta"
                     /calculated_mol_wt=74763
     Region          <1..19
                     /region_name="NES2-NLS_ChREBP-like"
                     /note="nuclear export signal 2 (NES2) and nuclear import
                     signal (NLS) domains found in carbohydrate-responsive
                     element-binding protein (ChREBP), MLX-interacting protein
                     (MLXIP), and similar proteins; cl45909"
                     /db_xref="CDD:459254"
     Region          232..>479
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Region          481..556
                     /region_name="bHLHzip_MLXIPL"
                     /note="basic Helix-Loop-Helix-zipper (bHLHzip) domain
                     found in MLX-interacting protein-like (MLXIPL) and similar
                     proteins; cd19689"
                     /db_xref="CDD:381532"
     Site            order(486,488..490,492..494,496..497,501,523..524)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381532"
     Site            order(500,503..504,506..507,510..512,525,528..529,532,
                     534..536,538..539,541..542,545,548..549,552..553,555..556)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381532"
     CDS             1..687
                     /gene="Mlxipl"
                     /gene_synonym="bHLHd14; ChREBP; Mlx; Wbscr14; WS-bHLH"
                     /coded_by="NM_001359237.1:410..2473"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="GeneID:58805"
                     /db_xref="MGI:MGI:1927999"
ORIGIN      
        1 mreyhkwriy ykkrlrkssr egdflapkqv eggwppperw ceqlfssvvp vllggseeep
       61 ggrqlldldc flsdisdtlf tmtqpspssl qlppedayvg nadmiqpdlt plqpslddfm
      121 eisdfftnyr ppqtptssny iespsfgpma dslfssgila pempspasss sssgmtphsg
      181 ntrlqarnsc sgpldpnpfl ssefllpedp ktkippapgp tpllpfptpv kvhglepctp
      241 spfptmappp sllpeeslls arfpftsapp apgvstlpap ttfvptpqpg pgpvpfsvdh
      301 lphgylepvf gphftvpqgm qprckpssps pggqkasppt lasataspta tatardnnpc
      361 ltqllraakp eqalepptmp gtllrppesp qdtvseipra raffppipap tpprpppgpa
      421 tlapprslvv pkaerlsppa ssgserrlsg dlnsiqpsga lsvhlsppqt vlsrgrvdnn
      481 kmenrrithi saeqkrrfni klgfdtlhgl vstlsaqpsl kvskattlqk taeyilmlqq
      541 eraamqeeaq qlrdeieeln aainlcqqql patgvpithq rfdqmrdmfd dyvrtrtlhn
      601 wkfwvfsili rplfesfngm vstaslhslr qtslawleqy cslpalrptv lnslrqlsts
      661 tsiltdpslv peqatravte gtlgrpl
//
LOCUS       NP_034764                135 aa            linear   ROD 09-OCT-2023
DEFINITION  fatty acid-binding protein 5 isoform 1 [Mus musculus].
ACCESSION   NP_034764
VERSION     NP_034764.1
DBSOURCE    REFSEQ: accession NM_010634.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 135)
  AUTHORS   Penman SL, Roeder NM, Berthold EC, Senetra AS, Marion M, Richardson
            BJ, White O, Fearby NL, McCurdy CR, Hamilton J, Sharma A and Thanos
            PK.
  TITLE     FABP5 is important for cognitive function and is an important
            regulator of the physiological effects and pharmacokinetics of
            acute Delta9 tetrahydrocannabinol inhalation in mice
  JOURNAL   Pharmacol Biochem Behav 231, 173633 (2023)
   PUBMED   37716413
  REMARK    GeneRIF: FABP5 is important for cognitive function and is an
            important regulator of the physiological effects and
            pharmacokinetics of acute Delta9 tetrahydrocannabinol inhalation in
            mice.
REFERENCE   2  (residues 1 to 135)
  AUTHORS   Chen Z, He C, Gao Z, Li Y, He Q, Wang Y and Cai C.
  TITLE     Polypyrimidine tract binding protein 1 exacerbates cardiac fibrosis
            by regulating fatty acid-binding protein 5
  JOURNAL   ESC Heart Fail 10 (3), 1677-1688 (2023)
   PUBMED   36788730
  REMARK    GeneRIF: Polypyrimidine tract binding protein 1 exacerbates cardiac
            fibrosis by regulating fatty acid-binding protein 5.
REFERENCE   3  (residues 1 to 135)
  AUTHORS   Guo Q, Kawahata I, Cheng A, Wang H, Jia W, Yoshino H and Fukunaga
            K.
  TITLE     Fatty acid-binding proteins 3 and 5 are involved in the initiation
            of mitochondrial damage in ischemic neurons
  JOURNAL   Redox Biol 59, 102547 (2023)
   PUBMED   36481733
  REMARK    GeneRIF: Fatty acid-binding proteins 3 and 5 are involved in the
            initiation of mitochondrial damage in ischemic neurons.
REFERENCE   4  (residues 1 to 135)
  AUTHORS   Reynolds JM, Liu Q, Brittingham KC, Liu Y, Gruenthal M, Gorgun CZ,
            Hotamisligil GS, Stout RD and Suttles J.
  TITLE     Deficiency of fatty acid-binding proteins in mice confers
            protection from development of experimental autoimmune
            encephalomyelitis
  JOURNAL   J Immunol 179 (1), 313-321 (2007)
   PUBMED   17579051
  REMARK    GeneRIF: Metabolic-inflammatory pathway cross-regulation by
            epidermal-type FABP contributes to adaptive immune responses and
            subsequent autoimmune inflammation.
REFERENCE   5  (residues 1 to 135)
  AUTHORS   Maeda K, Cao H, Kono K, Gorgun CZ, Furuhashi M, Uysal KT, Cao Q,
            Atsumi G, Malone H, Krishnan B, Minokoshi Y, Kahn BB, Parker RA and
            Hotamisligil GS.
  TITLE     Adipocyte/macrophage fatty acid binding proteins control integrated
            metabolic responses in obesity and diabetes
  JOURNAL   Cell Metab 1 (2), 107-119 (2005)
   PUBMED   16054052
REFERENCE   6  (residues 1 to 135)
  AUTHORS   Owada Y, Suzuki R, Iwasa H, Spener F and Kondo H.
  TITLE     Localization of epidermal-type fatty acid binding protein in the
            thymic epithelial cells of mice
  JOURNAL   Histochem Cell Biol 117 (1), 55-60 (2002)
   PUBMED   11819097
REFERENCE   7  (residues 1 to 135)
  AUTHORS   Yanase H, Shimizu H, Kanda T, Fujii H and Iwanaga T.
  TITLE     Cellular localization of the diazepam binding inhibitor (DBI) in
            the gastrointestinal tract of mice and its coexistence with the
            fatty acid binding protein (FABP)
  JOURNAL   Arch Histol Cytol 64 (4), 449-460 (2001)
   PUBMED   11757913
REFERENCE   8  (residues 1 to 135)
  AUTHORS   Hertzel AV and Bernlohr DA.
  TITLE     Cloning and chromosomal location of the murine keratinocyte
            lipid-binding protein gene
  JOURNAL   Gene 221 (2), 235-243 (1998)
   PUBMED   9795232
REFERENCE   9  (residues 1 to 135)
  AUTHORS   Bleck B, Hohoff C, Binas B, Rustow B, Dixkens C, Hameister H,
            Borchers T and Spener F.
  TITLE     Cloning and chromosomal localisation of the murine epidermal-type
            fatty acid binding protein gene (Fabpe)
  JOURNAL   Gene 215 (1), 123-130 (1998)
   PUBMED   9666100
REFERENCE   10 (residues 1 to 135)
  AUTHORS   Krieg P, Feil S, Furstenberger G and Bowden GT.
  TITLE     Tumor-specific overexpression of a novel keratinocyte lipid-binding
            protein. Identification and characterization of a cloned sequence
            activated during multistage carcinogenesis in mouse skin
  JOURNAL   J Biol Chem 268 (23), 17362-17369 (1993)
   PUBMED   8349619
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC157379.7, AK011551.1 and
            BE987062.1.
            
            Summary: The protein encoded by this gene is part of the fatty acid
            binding protein family (FABP). FABPs are a family of small, highly
            conserved, cytoplasmic proteins that bind long-chain fatty acids
            and other hydrophobic ligands and participate in fatty acid uptake,
            transport, and metabolism. In humans this gene has been associated
            with psoriasis and type 2 diabetes. In mouse deficiency of this
            gene in combination with a deficiency in Fabp4 confers protection
            against atherosclerosis, diet-induced obesity, insulin resistance
            and experimental autoimmune encephalomyelitis (the mouse model for
            multiple sclerosis). Alternative splicing results in multiple
            transcript variants that encode different protein isoforms. The
            mouse genome contains many pseudogenes similar to this locus.
            [provided by RefSeq, Jan 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X70100.1, CK792559.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..135
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 2.47 cM"
     Protein         1..135
                     /product="fatty acid-binding protein 5 isoform 1"
                     /note="fatty acid-binding protein, epidermal; epithelial
                     fatty acid-binding protein; keratinocyte lipid-binding
                     protein; epidermal-type fatty acid-binding protein;
                     psoriasis-associated fatty acid-binding protein homolog"
                     /calculated_mol_wt=15006
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:Q01469; propagated from
                     UniProtKB/Swiss-Prot (Q05816.3)"
     Site            3
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P55053; propagated from
                     UniProtKB/Swiss-Prot (Q05816.3)"
     Region          6..133
                     /region_name="FABP5"
                     /note="fatty acid binding protein 5; cd19468"
                     /db_xref="CDD:381243"
     Site            order(7,19,22..23,26,28,32..33,35..36,39,41,43,45,52,54,
                     56,58,60..61,63..65,67,75..79,81,94,96,107,109,116,118,
                     120,129,131)
                     /site_type="other"
                     /note="ligand binding cavity [chemical binding]"
                     /db_xref="CDD:381243"
     Site            order(22..23,26,32,36,41,56,60..61,78..79,107,118,120,129,
                     131)
                     /site_type="other"
                     /note="endocannabinoid binding site [chemical binding]"
                     /db_xref="CDD:381243"
     Region          24..34
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000250|UniProtKB:Q01469"
                     /note="propagated from UniProtKB/Swiss-Prot (Q05816.3)"
     Site            131
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q01469; propagated from
                     UniProtKB/Swiss-Prot (Q05816.3)"
     CDS             1..135
                     /gene="Fabp5"
                     /gene_synonym="E-FABP; Fabpe; Klbp; mal1; PA-FABP"
                     /coded_by="NM_010634.3:56..463"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS38388.1"
                     /db_xref="GeneID:16592"
                     /db_xref="MGI:MGI:101790"
ORIGIN      
        1 maslkdlegk wrlmeshgfe eymkelgvgl alrkmaamak pdciitcdgn nitvktestv
       61 kttvfscnlg ekfdettadg rktetvctfq dgalvqhqqw dgkestitrk lkdgkmivec
      121 vmnnatctrv yekvq
//
LOCUS       NP_084108                315 aa            linear   ROD 09-OCT-2023
DEFINITION  DDRGK domain-containing protein 1 isoform a precursor [Mus
            musculus].
ACCESSION   NP_084108 XP_485067 XP_907023 XP_907026 XP_907027 XP_923340
            XP_930671 XP_930674 XP_930676 XP_999112 XP_999134 XP_999153
            XP_999171
VERSION     NP_084108.1
DBSOURCE    REFSEQ: accession NM_029832.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 315)
  AUTHORS   Yang X, Zhou T, Wang X, Xia Y, Cao X, Cheng X, Cao Y, Ma P, Ma H,
            Qin A and Zhao J.
  TITLE     Loss of DDRGK1 impairs IRE1alpha UFMylation in spondyloepiphyseal
            dysplasia
  JOURNAL   Int J Biol Sci 19 (15), 4709-4725 (2023)
   PUBMED   37781516
  REMARK    GeneRIF: Loss of DDRGK1 impairs IRE1alpha UFMylation in
            spondyloepiphyseal dysplasia.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 315)
  AUTHORS   Tandra V, Anderson T, Ayala JD, Weintraub NL, Singh N, Li H and Li
            J.
  TITLE     Ufmylation of UFBP1 Is Dispensable for Endoplasmic Reticulum Stress
            Response, Embryonic Development, and Cardiac and Intestinal
            Homeostasis
  JOURNAL   Cells 12 (15), 1923 (2023)
   PUBMED   37566002
  REMARK    GeneRIF: Ufmylation of UFBP1 Is Dispensable for Endoplasmic
            Reticulum Stress Response, Embryonic Development, and Cardiac and
            Intestinal Homeostasis.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 315)
  AUTHORS   Chen F, Sheng L, Zhou T, Yan L, Loveless R, Li H, Teng Y and Cai Y.
  TITLE     Loss of Ufl1/Ufbp1 in hepatocytes promotes liver pathological
            damage and carcinogenesis through activating mTOR signaling
  JOURNAL   J Exp Clin Cancer Res 42 (1), 110 (2023)
   PUBMED   37131258
  REMARK    GeneRIF: Loss of Ufl1/Ufbp1 in hepatocytes promotes liver
            pathological damage and carcinogenesis through activating mTOR
            signaling.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 315)
  AUTHORS   Li H, Yu Z, Niu Z, Cheng Y, Wei Z, Cai Y, Ma F, Hu L, Zhu J and
            Zhang W.
  TITLE     A neuroprotective role of Ufmylation through Atg9 in the aging
            brain of Drosophila
  JOURNAL   Cell Mol Life Sci 80 (5), 129 (2023)
   PUBMED   37086384
  REMARK    GeneRIF: A neuroprotective role of Ufmylation through Atg9 in the
            aging brain of Drosophila.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 315)
  AUTHORS   Weisz-Hubshman M, Egunsula AT, Dawson B, Castellon A, Jiang MM,
            Chen-Evenson Y, Zhiyin Y, Lee B and Bae Y.
  TITLE     DDRGK1 is required for the proper development and maintenance of
            the growth plate cartilage
  JOURNAL   Hum Mol Genet 31 (16), 2820-2830 (2022)
   PUBMED   35377455
REFERENCE   6  (residues 1 to 315)
  AUTHORS   Yoo HM, Kang SH, Kim JY, Lee JE, Seong MW, Lee SW, Ka SH, Sou YS,
            Komatsu M, Tanaka K, Lee ST, Noh DY, Baek SH, Jeon YJ and Chung CH.
  TITLE     Modification of ASC1 by UFM1 is crucial for ERalpha transactivation
            and breast cancer development
  JOURNAL   Mol Cell 56 (2), 261-274 (2014)
   PUBMED   25219498
REFERENCE   7  (residues 1 to 315)
  AUTHORS   Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H,
            Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T,
            Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P,
            Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ,
            Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD,
            Flicek P, Skarnes WC, Mallon AM and Parkinson H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (residues 1 to 315)
  AUTHORS   Lemaire K, Moura RF, Granvik M, Igoillo-Esteve M, Hohmeier HE,
            Hendrickx N, Newgard CB, Waelkens E, Cnop M and Schuit F.
  TITLE     Ubiquitin fold modifier 1 (UFM1) and its target UFBP1 protect
            pancreatic beta cells from ER stress-induced apoptosis
  JOURNAL   PLoS One 6 (4), e18517 (2011)
   PUBMED   21494687
  REMARK    GeneRIF: These data suggest that UFM1-UFBP1 participate in
            preventing endoplasmic reticulum stress-induced apoptosis in
            protein secretory cells.
            Publication Status: Online-Only
REFERENCE   9  (residues 1 to 315)
  AUTHORS   Wu J, Lei G, Mei M, Tang Y and Li H.
  TITLE     A novel C53/LZAP-interacting protein regulates stability of
            C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and
            modulates NF-kappaB signaling
  JOURNAL   J Biol Chem 285 (20), 15126-15136 (2010)
   PUBMED   20228063
REFERENCE   10 (residues 1 to 315)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL772162.4 and AL731707.12.
            
            On or before Jul 17, 2006 this sequence version replaced
            XP_923340.1, XP_930671.1, XP_930676.1, XP_930674.1, XP_485067.1,
            XP_907023.1, XP_907027.1, XP_907026.1, XP_999171.1, XP_999153.1,
            XP_999134.1, XP_999112.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC115616.2, ERR3835353.147285.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..315
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 63.24 cM"
     Protein         1..315
                     /product="DDRGK domain-containing protein 1 isoform a
                     precursor"
                     /note="DDRGK domain-containing protein 1; UFM1-binding
                     protein 1 containing a PCI domain; UFM1-binding and PCI
                     domain-containing protein 1"
                     /calculated_mol_wt=32910
     Region          1..115
                     /region_name="Mediates interaction with CDK5RAP3.
                     /evidence=ECO:0000250|UniProtKB:Q96HY6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80WW9.2)"
     sig_peptide     1..28
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q80WW9.2)"
                     /calculated_mol_wt=3086
     mat_peptide     29..315
                     /product="DDRGK domain-containing protein 1.
                     /id=PRO_0000021034"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80WW9.2)"
                     /calculated_mol_wt=32910
     Region          30..184
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80WW9.2)"
     Site            73
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96HY6; propagated from
                     UniProtKB/Swiss-Prot (Q80WW9.2)"
     Region          116..304
                     /region_name="DDRGK"
                     /note="DDRGK domain; pfam09756"
                     /db_xref="CDD:370664"
     Region          119..217
                     /region_name="Mediates interaction with TRIP4.
                     /evidence=ECO:0000250|UniProtKB:Q96HY6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80WW9.2)"
     Region          217..315
                     /region_name="Mediates interaction with UFL1.
                     /evidence=ECO:0000250|UniProtKB:Q96HY6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80WW9.2)"
     CDS             1..315
                     /gene="Ddrgk1"
                     /gene_synonym="1110001I20Rik; 2600009E05Rik; Ufbp1"
                     /coded_by="NM_029832.3:56..1003"
                     /note="isoform a precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS38243.1"
                     /db_xref="GeneID:77006"
                     /db_xref="MGI:MGI:1924256"
ORIGIN      
        1 mvgpwvylva avlliglilf ltrsrgraaa adgeplhnee eragagqvgr slpqeseeqr
       61 tgsrprrrrd lgsrlqaqrr aqrvawedgd envgqtvipa qeeegiekpa evhptgkiga
      121 kklrkleekq arkaqreaee aereerkrle sqreaewkke eerlrlkeeq keeeerkaqe
      181 eqarreheey lklkeafvve eegvsetmte eqshsfltef inyikkskvv lledlafqmg
      241 lrtqdainri qdlltegtlt gviddrgkfi yitpeelaav anfirqrgrv sitelaqasn
      301 sliswgqdlp aqasa
//
LOCUS       NP_084047                375 aa            linear   ROD 09-OCT-2023
DEFINITION  G-protein coupled estrogen receptor 1 [Mus musculus].
ACCESSION   NP_084047 XP_355659
VERSION     NP_084047.2
DBSOURCE    REFSEQ: accession NM_029771.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 375)
  AUTHORS   Sohn P, McLaughlin MR, Krishnan P, Wu W, Slak Rupnik M, Takasu A,
            Senda T, Lee CC, Kono T and Evans-Molina C.
  TITLE     Stromal Interaction Molecule 1 Maintains beta-Cell Identity and
            Function in Female Mice Through Preservation of G-Protein-Coupled
            Estrogen Receptor 1 Signaling
  JOURNAL   Diabetes 72 (10), 1433-1445 (2023)
   PUBMED   37478155
  REMARK    GeneRIF: Stromal Interaction Molecule 1 Maintains beta-Cell
            Identity and Function in Female Mice Through Preservation of
            G-Protein-Coupled Estrogen Receptor 1 Signaling.
REFERENCE   2  (residues 1 to 375)
  AUTHORS   Zhang C, Niu JG, Kong XR, Mi XJ, Liu Q, Chen FF, Rong WF and Liu J.
  TITLE     G protein-coupled estrogen receptor 1 deficiency impairs adult
            hippocampal neurogenesis in mice with schizophrenia
  JOURNAL   J Chem Neuroanat 132, 102319 (2023)
   PUBMED   37495162
  REMARK    GeneRIF: G protein-coupled estrogen receptor 1 deficiency impairs
            adult hippocampal neurogenesis in mice with schizophrenia.
            Review article
REFERENCE   3  (residues 1 to 375)
  AUTHORS   Xu F, Ma J, Wang X, Wang X, Fang W, Sun J, Li Z and Liu J.
  TITLE     The Role of G Protein-Coupled Estrogen Receptor (GPER) in Vascular
            Pathology and Physiology
  JOURNAL   Biomolecules 13 (9), 1410 (2023)
   PUBMED   37759810
  REMARK    GeneRIF: The Role of G Protein-Coupled Estrogen Receptor (GPER) in
            Vascular Pathology and Physiology.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 375)
  AUTHORS   Pal U, Manjegowda MC, Singh N, Saikia S, Philip BS, Jyoti Kalita D,
            Kumar Rai A, Sarma A, Raphael V, Modi D, Chandra Kataki A and
            Mukund Limaye A.
  TITLE     The G-protein-coupled estrogen receptor, a gene co-expressed with
            ERalpha in breast tumors, is regulated by estrogen-ERalpha
            signalling in ERalpha positive breast cancer cells
  JOURNAL   Gene 877, 147548 (2023)
   PUBMED   37279863
  REMARK    GeneRIF: The G-protein-coupled estrogen receptor, a gene
            co-expressed with ERalpha in breast tumors, is regulated by
            estrogen-ERalpha signalling in ERalpha positive breast cancer
            cells.
REFERENCE   5  (residues 1 to 375)
  AUTHORS   da Silva FER, Cordeiro RC, de Carvalho Lima CN, Cardozo PL,
            Vasconcelos GS, Monte AS, Sanders LLO, Vasconcelos SMM, de Lucena
            DF, Cruz BF, Nicolato R, Seeman MV, Ribeiro FM and Macedo DS.
  TITLE     Sex and the Estrous-Cycle Phase Influence the Expression of G
            Protein-Coupled Estrogen Receptor 1 (GPER) in Schizophrenia:
            Translational Evidence for a New Target
  JOURNAL   Mol Neurobiol 60 (7), 3650-3663 (2023)
   PUBMED   36917419
  REMARK    GeneRIF: Sex and the Estrous-Cycle Phase Influence the Expression
            of G Protein-Coupled Estrogen Receptor 1 (GPER) in Schizophrenia:
            Translational Evidence for a New Target.
REFERENCE   6  (residues 1 to 375)
  AUTHORS   Wang C, Dehghani B, Magrisso IJ, Rick EA, Bonhomme E, Cody DB,
            Elenich LA, Subramanian S, Murphy SJ, Kelly MJ, Rosenbaum JS,
            Vandenbark AA and Offner H.
  TITLE     GPR30 contributes to estrogen-induced thymic atrophy
  JOURNAL   Mol Endocrinol 22 (3), 636-648 (2008)
   PUBMED   18063692
  REMARK    GeneRIF: GPR30 is indispensable for thymocyte apoptosis that
            preferentially occurs in T-cell receptor beta chain double-positive
            thymocytes.
REFERENCE   7  (residues 1 to 375)
  AUTHORS   Filardo E, Quinn J, Pang Y, Graeber C, Shaw S, Dong J and Thomas P.
  TITLE     Activation of the novel estrogen receptor G protein-coupled
            receptor 30 (GPR30) at the plasma membrane
  JOURNAL   Endocrinology 148 (7), 3236-3245 (2007)
   PUBMED   17379646
  REMARK    GeneRIF: Results suggest that GPR30 functions as a plasma membrane
            receptor.
REFERENCE   8  (residues 1 to 375)
  AUTHORS   Wang J, Scully K, Zhu X, Cai L, Zhang J, Prefontaine GG, Krones A,
            Ohgi KA, Zhu P, Garcia-Bassets I, Liu F, Taylor H, Lozach J, Jayes
            FL, Korach KS, Glass CK, Fu XD and Rosenfeld MG.
  TITLE     Opposing LSD1 complexes function in developmental gene activation
            and repression programmes
  JOURNAL   Nature 446 (7138), 882-887 (2007)
   PUBMED   17392792
REFERENCE   9  (residues 1 to 375)
  AUTHORS   Ylikomi T, Vienonen A and Ahola TM.
  TITLE     G protein-coupled receptor 30 down-regulates cofactor expression
            and interferes with the transcriptional activity of glucocorticoid
  JOURNAL   Eur J Biochem 271 (21), 4159-4168 (2004)
   PUBMED   15511221
  REMARK    GeneRIF: G protein-coupled receptor 30 down-regulates cofactor
            expression and interferes with the transcriptional activity of
            glucocorticoid
REFERENCE   10 (residues 1 to 375)
  AUTHORS   Feng Y and Gregor P.
  TITLE     Cloning of a novel member of the G protein-coupled receptor family
            related to peptide receptors
  JOURNAL   Biochem Biophys Res Commun 231 (3), 651-654 (1997)
   PUBMED   9070864
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK030375.1, BC138616.1 and CX204119.1.
            
            On Jul 23, 2009 this sequence version replaced NP_084047.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030375.1, AK018203.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..375
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 78.58 cM"
     Protein         1..375
                     /product="G-protein coupled estrogen receptor 1"
                     /note="mER; membrane estrogen receptor; G-protein coupled
                     receptor 30; chemoattractant receptor-like 2;
                     constitutively expressed peptide-like receptor like"
                     /calculated_mol_wt=42348
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:Q99527; propagated from
                     UniProtKB/Swiss-Prot (Q8BMP4.2)"
     Site            32
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8BMP4.2)"
     Site            44
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8BMP4.2)"
     Region          60..335
                     /region_name="7tmA_GPER1"
                     /note="G protein-coupled estrogen receptor 1, member of
                     the class A family of seven-transmembrane G
                     protein-coupled receptors; cd14989"
                     /db_xref="CDD:320120"
     Region          61..87
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:320120"
     Site            63..84
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BMP4.2)"
     Region          94..119
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:320120"
     Site            97..120
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BMP4.2)"
     Site            order(115,118..119,130..135,137..138,141,186,188..192,211,
                     214..216,218..220,222..223,272,275..276,278..279,282,
                     302..303,305..307,310,313..314)
                     /site_type="other"
                     /note="putative ligand binding pocket [chemical binding]"
                     /db_xref="CDD:320120"
     Region          130..160
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:320120"
     Site            133..153
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BMP4.2)"
     Region          173..194
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:320120"
     Site            176..194
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BMP4.2)"
     Region          211..238
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:320120"
     Site            221..236
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BMP4.2)"
     Region          252..282
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:320120"
     Site            260..280
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BMP4.2)"
     Region          303..328
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:320120"
     Site            307..327
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BMP4.2)"
     CDS             1..375
                     /gene="Gper1"
                     /gene_synonym="6330420K13Rik; Ceprl; CMKRL2; FEG-1;
                     GPCR-Br; Gper; Gpr30"
                     /coded_by="NM_029771.3:611..1738"
                     /db_xref="CCDS:CCDS19811.1"
                     /db_xref="GeneID:76854"
                     /db_xref="MGI:MGI:1924104"
ORIGIN      
        1 mdattpaqtv gveiylgpvw papsnstpla lnlslalred apgnltgdls ehqqyvialf
       61 lsclytiflf pigfvgnili lvvnisfrek mtipdlyfin laaadlilva dslievfnld
      121 eqyydiavlc tfmslflqin myssvffltw msfdrylala kamrcglfrt khharlscgl
      181 iwmasvsatl vpftavhlrh teeacfcfad vrevqwlevt lgfimpfaii glcyslivra
      241 lirahrhrgl rprrqkalrm ifavvlvffi cwlpenvfis vhllqwtqpg dtpckqsfrh
      301 aypltghivn laafsnscln pliysflget frdklrlyve qktslpalnr fchatlkavi
      361 pdsteqsevr fssav
//
LOCUS       NP_067369                411 aa            linear   ROD 09-OCT-2023
DEFINITION  Z-DNA-binding protein 1 isoform 1 [Mus musculus].
ACCESSION   NP_067369
VERSION     NP_067369.2
DBSOURCE    REFSEQ: accession NM_021394.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 411)
  AUTHORS   Sharma BR, Karki R, Rajesh Y and Kanneganti TD.
  TITLE     Immune regulator IRF1 contributes to ZBP1-, AIM2-, RIPK1-, and
            NLRP12-PANoptosome activation and inflammatory cell death
            (PANoptosis)
  JOURNAL   J Biol Chem 299 (9), 105141 (2023)
   PUBMED   37557956
  REMARK    GeneRIF: Immune regulator IRF1 contributes to ZBP1-, AIM2-, RIPK1-,
            and NLRP12-PANoptosome activation and inflammatory cell death
            (PANoptosis).
REFERENCE   2  (residues 1 to 411)
  AUTHORS   Lei Y, VanPortfliet JJ, Chen YF, Bryant JD, Li Y, Fails D,
            Torres-Odio S, Ragan KB, Deng J, Mohan A, Wang B, Brahms ON, Yates
            SD, Spencer M, Tong CW, Bosenberg MW, West LC, Shadel GS, Shutt TE,
            Upton JW, Li P and West AP.
  TITLE     Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes
            cardiotoxicity
  JOURNAL   Cell 186 (14), 3013-3032 (2023)
   PUBMED   37352855
  REMARK    GeneRIF: Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS
            promotes cardiotoxicity.
REFERENCE   3  (residues 1 to 411)
  AUTHORS   Cheng P, Jian Q, Fu Z, Deng R and Ma Y.
  TITLE     Inhibition of DAI refrains dendritic cells from maturation and
            prolongs murine islet and skin allograft survival
  JOURNAL   Front Immunol 14, 1182851 (2023)
   PUBMED   37197662
  REMARK    GeneRIF: Inhibition of DAI refrains dendritic cells from maturation
            and prolongs murine islet and skin allograft survival.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 411)
  AUTHORS   Enzan N, Matsushima S, Ikeda S, Okabe K, Ishikita A, Yamamoto T,
            Sada M, Miyake R, Tsutsui Y, Nishimura R, Toyohara T, Ikeda Y,
            Shojima Y, Miyamoto HD, Tadokoro T, Ikeda M, Abe K, Ide T, Kinugawa
            S and Tsutsui H.
  TITLE     ZBP1 Protects Against mtDNA-Induced Myocardial Inflammation in
            Failing Hearts
  JOURNAL   Circ Res 132 (9), 1110-1126 (2023)
   PUBMED   36974722
  REMARK    GeneRIF: ZBP1 Protects Against mtDNA-Induced Myocardial
            Inflammation in Failing Hearts.
REFERENCE   5  (residues 1 to 411)
  AUTHORS   Li S, Zhang Y, Guan Z, Ye M, Li H, You M, Zhou Z, Zhang C, Zhang F,
            Lu B, Zhou P and Peng K.
  TITLE     SARS-CoV-2 Z-RNA activates the ZBP1-RIPK3 pathway to promote
            virus-induced inflammatory responses
  JOURNAL   Cell Res 33 (3), 201-214 (2023)
   PUBMED   36650286
  REMARK    GeneRIF: SARS-CoV-2 Z-RNA activates the ZBP1-RIPK3 pathway to
            promote virus-induced inflammatory responses.
REFERENCE   6  (residues 1 to 411)
  AUTHORS   Wang Z, Choi MK, Ban T, Yanai H, Negishi H, Lu Y, Tamura T, Takaoka
            A, Nishikura K and Taniguchi T.
  TITLE     Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other
            DNA-sensing molecules
  JOURNAL   Proc Natl Acad Sci U S A 105 (14), 5477-5482 (2008)
   PUBMED   18375758
  REMARK    GeneRIF: mechanism of DAI activation and the complex regulatory
            mechanisms underlying DNA-mediated protective and pathologic immune
            responses.
REFERENCE   7  (residues 1 to 411)
  AUTHORS   Ishii KJ, Kawagoe T, Koyama S, Matsui K, Kumar H, Kawai T, Uematsu
            S, Takeuchi O, Takeshita F, Coban C and Akira S.
  TITLE     TANK-binding kinase-1 delineates innate and adaptive immune
            responses to DNA vaccines
  JOURNAL   Nature 451 (7179), 725-729 (2008)
   PUBMED   18256672
REFERENCE   8  (residues 1 to 411)
  AUTHORS   Takaoka A, Wang Z, Choi MK, Yanai H, Negishi H, Ban T, Lu Y,
            Miyagishi M, Kodama T, Honda K, Ohba Y and Taniguchi T.
  TITLE     DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of
            innate immune response
  JOURNAL   Nature 448 (7152), 501-505 (2007)
   PUBMED   17618271
  REMARK    GeneRIF: observations underscore an integral role of DAI
            (DLM-1/ZBP1) in the DNA-mediated activation of innate immune
            responses
REFERENCE   9  (residues 1 to 411)
  AUTHORS   Schwartz T, Behlke J, Lowenhaupt K, Heinemann U and Rich A.
  TITLE     Structure of the DLM-1-Z-DNA complex reveals a conserved family of
            Z-DNA-binding proteins
  JOURNAL   Nat Struct Biol 8 (9), 761-765 (2001)
   PUBMED   11524677
  REMARK    GeneRIF: shares common structure-specific recognition core within
            the binding domain with an RNA editing enzyme but binds Z-DNA
REFERENCE   10 (residues 1 to 411)
  AUTHORS   Fu Y, Comella N, Tognazzi K, Brown LF, Dvorak HF and Kocher O.
  TITLE     Cloning of DLM-1, a novel gene that is up-regulated in activated
            macrophages, using RNA differential display
  JOURNAL   Gene 240 (1), 157-163 (1999)
   PUBMED   10564822
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY170802.1, AX775969.1, AL837509.11 and AI643886.1.
            
            On Nov 19, 2008 this sequence version replaced NP_067369.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because C57BL/6 strain transcript sequence
            from the C57BL/6 strain consistent with the reference genome
            assembly was not available for all regions of the RefSeq
            transcript. The extent of this transcript is supported by
            transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF136520.1, BC020033.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..411
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 95.83 cM"
     Protein         1..411
                     /product="Z-DNA-binding protein 1 isoform 1"
                     /note="tumor stroma and activated macrophage protein
                     DLM-1; DNA-dependent activator of IFN-regulatory factors"
                     /calculated_mol_wt=44140
     Region          8..72
                     /region_name="Zalpha"
                     /note="Z-DNA-binding domain in adenosine deaminases;
                     smart00550"
                     /db_xref="CDD:128823"
     Region          60..86
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QY24.1)"
     Region          84..147
                     /region_name="z-alpha"
                     /note="Adenosine deaminase z-alpha domain; cl02659"
                     /db_xref="CDD:295419"
     Region          188..205
                     /region_name="RIP homotypic interaction motif (RHIM) 1.
                     /evidence=ECO:0000269|PubMed:19590578"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QY24.1)"
     Region          237..261
                     /region_name="RIP homotypic interaction motif (RHIM) 2.
                     /evidence=ECO:0000269|PubMed:19590578"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QY24.1)"
     Region          263..303
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QY24.1)"
     Region          332..411
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QY24.1)"
     CDS             1..411
                     /gene="Zbp1"
                     /gene_synonym="2010010H03Rik; Dai; Dlm1; mZaDLM"
                     /coded_by="NM_021394.2:148..1383"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS17142.1"
                     /db_xref="GeneID:58203"
                     /db_xref="MGI:MGI:1927449"
ORIGIN      
        1 maeapvdlst gdnleqkilq vlsddggpvk igqlvkkcqv pkktlnqvly rlkkedrvss
       61 pepatwsigg aasgdgapai penssaqpsl derilrflea ngphralhia kalgmttake
      121 vnpllysmrn khllsydgqt wkiyhsrqeg qdiahsgvtq espaiicqhn pvnmicqqga
      181 nshisiansn aiqighgnvi vrekacgepg prtshplpla wdasaqdmpp vahgaqyiym
      241 dksllqqvql ghhnemslvg dagkhpsysf sdsppevstt tadpgasfnm qtsepgphpe
      301 gdtvqtvhik scfledatig ngnkmtihlr skgevmesgd seepkkedtg tsseatpprs
      361 cqhtpsdsml ptselramal gdsspqttep vlrehevqdi essqdtglsk q
//
LOCUS       NP_067430                864 aa            linear   ROD 09-OCT-2023
DEFINITION  carbohydrate-responsive element-binding protein isoform 1 [Mus
            musculus].
ACCESSION   NP_067430
VERSION     NP_067430.2
DBSOURCE    REFSEQ: accession NM_021455.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 864)
  AUTHORS   Li L, Long J, Mise K, Poungavrin N, Lorenzi PL, Mahmud I, Tan L,
            Saha PK, Kanwar YS, Chang BH and Danesh FR.
  TITLE     The transcription factor ChREBP links mitochondrial lipidomes to
            mitochondrial morphology and progression of diabetic kidney disease
  JOURNAL   J Biol Chem 299 (9), 105185 (2023)
   PUBMED   37611830
  REMARK    GeneRIF: The transcription factor ChREBP links mitochondrial
            lipidomes to mitochondrial morphology and progression of diabetic
            kidney disease.
REFERENCE   2  (residues 1 to 864)
  AUTHORS   Sargsyan A, Doridot L, Hannou SA, Tong W, Srinivasan H, Ivison R,
            Monn R, Kou HH, Haldeman JM, Arlotto M, White PJ, Grimsrud PA,
            Astapova I, Tsai LT and Herman MA.
  TITLE     HGFAC is a ChREBP-regulated hepatokine that enhances glucose and
            lipid homeostasis
  JOURNAL   JCI Insight 8 (1), e153740 (2023)
   PUBMED   36413406
  REMARK    GeneRIF: HGFAC is a ChREBP-regulated hepatokine that enhances
            glucose and lipid homeostasis.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 864)
  AUTHORS   Seo E, Nam H and Jun HS.
  TITLE     Reactive oxygen species induce HNF-4alpha expression via the
            ASK1-CREB pathway, promoting ChREBP expression and lipogenesis in
            hepatocytes
  JOURNAL   Life Sci 310, 121042 (2022)
   PUBMED   36208661
  REMARK    GeneRIF: Reactive oxygen species induce HNF-4alpha expression via
            the ASK1-CREB pathway, promoting ChREBP expression and lipogenesis
            in hepatocytes.
REFERENCE   4  (residues 1 to 864)
  AUTHORS   Thevkar-Nagesh P, Habault J, Voisin M, Ruff SE, Ha S, Ruoff R, Chen
            X, Rawal S, Zahr T, Szabo G, Rogatsky I, Fisher EA and Garabedian
            MJ.
  TITLE     Transcriptional regulation of Acsl1 by CHREBP and NF-kappa B in
            macrophages during hyperglycemia and inflammation
  JOURNAL   PLoS One 17 (9), e0272986 (2022)
   PUBMED   36054206
  REMARK    GeneRIF: Transcriptional regulation of Acsl1 by CHREBP and NF-kappa
            B in macrophages during hyperglycemia and inflammation.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 864)
  AUTHORS   Katz LS, Brill G, Zhang P, Kumar A, Baumel-Alterzon S, Honig LB,
            Gomez-Banoy N, Karakose E, Tanase M, Doridot L, Alvarsson A,
            Davenport B, Wang P, Lambertini L, Stanley SA, Homann D, Stewart
            AF, Lo JC, Herman MA, Garcia-Ocana A and Scott DK.
  TITLE     Maladaptive positive feedback production of ChREBPbeta underlies
            glucotoxic beta-cell failure
  JOURNAL   Nat Commun 13 (1), 4423 (2022)
   PUBMED   35908073
  REMARK    Erratum:[Nat Commun. 2022 Sep 27;13(1):5681. PMID: 36167859]
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 864)
  AUTHORS   Kawaguchi T, Takenoshita M, Kabashima T and Uyeda K.
  TITLE     Glucose and cAMP regulate the L-type pyruvate kinase gene by
            phosphorylation/dephosphorylation of the carbohydrate response
            element binding protein
  JOURNAL   Proc Natl Acad Sci U S A 98 (24), 13710-13715 (2001)
   PUBMED   11698644
REFERENCE   7  (residues 1 to 864)
  AUTHORS   Cairo S, Merla G, Urbinati F, Ballabio A and Reymond A.
  TITLE     WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted
            region, is a new member of the Mlx transcription factor network
  JOURNAL   Hum Mol Genet 10 (6), 617-627 (2001)
   PUBMED   11230181
REFERENCE   8  (residues 1 to 864)
  AUTHORS   Valero MC, de Luis O, Cruces J and Perez Jurado LA.
  TITLE     Fine-scale comparative mapping of the human 7q11.23 region and the
            orthologous region on mouse chromosome 5G: the low-copy repeats
            that flank the Williams-Beuren syndrome deletion arose at
            breakpoint sites of an evolutionary inversion(s)
  JOURNAL   Genomics 69 (1), 1-13 (2000)
   PUBMED   11013070
REFERENCE   9  (residues 1 to 864)
  AUTHORS   de Luis O, Valero MC and Jurado LA.
  TITLE     WBSCR14, a putative transcription factor gene deleted in
            Williams-Beuren syndrome: complete characterisation of the human
            gene and the mouse ortholog
  JOURNAL   Eur J Hum Genet 8 (3), 215-222 (2000)
   PUBMED   10780788
REFERENCE   10 (residues 1 to 864)
  AUTHORS   Billin AN, Eilers AL, Queva C and Ayer DE.
  TITLE     Mlx, a novel Max-like BHLHZip protein that interacts with the Max
            network of transcription factors
  JOURNAL   J Biol Chem 274 (51), 36344-36350 (1999)
   PUBMED   10593926
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC024607.3.
            
            On Aug 28, 2003 this sequence version replaced NP_067430.1.
            
            Transcript Variant: This variant (1, also known as zeta) encodes
            the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF245475.1, AF156604.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..864
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 75.0 cM"
     Protein         1..864
                     /product="carbohydrate-responsive element-binding protein
                     isoform 1"
                     /note="putative hepatic transcription factor; MLX
                     interactor; Williams-Beuren syndrome chromosome region 14
                     homolog; Max-like protein; carbohydrate-responsive
                     element-binding protein; MLX interacting protein-like
                     beta"
                     /calculated_mol_wt=94744
     Region          15..41
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99MZ3.1)"
     Site            20
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q99MZ3.1)"
     Site            23
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:18630941, ECO:0007744|PubMed:21183079;
                     propagated from UniProtKB/Swiss-Prot (Q99MZ3.1)"
     Site            25
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:18630941, ECO:0007744|PubMed:21183079;
                     propagated from UniProtKB/Swiss-Prot (Q99MZ3.1)"
     Site            27
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:18630941; propagated from
                     UniProtKB/Swiss-Prot (Q99MZ3.1)"
     Region          53..77
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99MZ3.1)"
     Region          81..196
                     /region_name="NES2-NLS_ChREBP"
                     /note="nuclear export signal 2 (NES2) and nuclear import
                     signal (NLS) domains found in carbohydrate-responsive
                     element-binding protein (ChREBP), and similar proteins;
                     cd21771"
                     /db_xref="CDD:439287"
     Site            order(117,121,124,127..131,134)
                     /site_type="other"
                     /note="putative heterodimer interface [polypeptide
                     binding]"
                     /db_xref="CDD:439287"
     Site            order(124,127..128)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:439287"
     Site            196
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9NP71; propagated from
                     UniProtKB/Swiss-Prot (Q99MZ3.1)"
     Region          332..397
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99MZ3.1)"
     Region          409..>656
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Region          449..468
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99MZ3.1)"
     Region          489..533
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99MZ3.1)"
     Region          547..570
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99MZ3.1)"
     Site            566
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by AMPK.
                     /evidence=ECO:0000250|UniProtKB:Q8VIP2; propagated from
                     UniProtKB/Swiss-Prot (Q99MZ3.1)"
     Region          583..602
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99MZ3.1)"
     Site            614
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9NP71; propagated from
                     UniProtKB/Swiss-Prot (Q99MZ3.1)"
     Site            626
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q99MZ3.1)"
     Site            643
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q99MZ3.1)"
     Region          658..733
                     /region_name="bHLHzip_MLXIPL"
                     /note="basic Helix-Loop-Helix-zipper (bHLHzip) domain
                     found in MLX-interacting protein-like (MLXIPL) and similar
                     proteins; cd19689"
                     /db_xref="CDD:381532"
     Site            order(663,665..667,669..671,673..674,678,700..701)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381532"
     Site            order(677,680..681,683..684,687..689,702,705..706,709,
                     711..713,715..716,718..719,722,725..726,729..730,732..733)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381532"
     Region          715..736
                     /region_name="Leucine-zipper"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99MZ3.1)"
     CDS             1..864
                     /gene="Mlxipl"
                     /gene_synonym="bHLHd14; ChREBP; Mlx; Wbscr14; WS-bHLH"
                     /coded_by="NM_021455.5:33..2627"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS39316.1"
                     /db_xref="GeneID:58805"
                     /db_xref="MGI:MGI:1927999"
ORIGIN      
        1 maraladlsv nlqvprvvps pdsdsdtdle dpsprrsagg lhrsqvihsg hfmvssphsd
       61 sltrrrdqeg pvgladfgpr sidptlthlf eclslaysgk lvspkwknfk glkllcrdki
      121 rlnnaiwraw yiqyvqrrks pvcgfvtplq gseadehrkp eavilegnyw krrievvmre
      181 yhkwriyykk rlrkssregd flapkqvegg wppperwceq lfssvvpvll ggseeepggr
      241 qlldldcfls disdtlftmt qpspsslqlp pedayvgnad miqpdltplq pslddfmeis
      301 dfftnyrppq tptssnyies psfgpmadsl fssgilapem pspassssss gmtphsgntr
      361 lqarnscsgp ldpnpflsse fllpedpktk ippapgptpl lpfptpvkvh glepctpspf
      421 ptmapppsll peesllsarf pftsappapg vstlpapttf vptpqpgpgp vpfsvdhlph
      481 gylepvfgph ftvpqgmqpr ckpsspspgg qkaspptlas atasptatat ardnnpcltq
      541 llraakpeqa lepptmpgtl lrppespqdt vseipraraf fppipaptpp rpppgpatla
      601 pprslvvpka erlsppassg serrlsgdln siqpsgalsv hlsppqtvls rgrvdnnkme
      661 nrrithisae qkrrfniklg fdtlhglvst lsaqpslkvs kattlqktae yilmlqqera
      721 amqeeaqqlr deieelnaai nlcqqqlpat gvpithqrfd qmrdmfddyv rtrtlhnwkf
      781 wvfsilirpl fesfngmvst aslhslrqts lawleqycsl palrptvlns lrqlststsi
      841 ltdpslvpeq atravtegtl grpl
//
LOCUS       NP_001397154             531 aa            linear   ROD 09-OCT-2023
DEFINITION  nuclear respiratory factor 1 isoform d [Mus musculus].
ACCESSION   NP_001397154
VERSION     NP_001397154.1
DBSOURCE    REFSEQ: accession NM_001410225.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 531)
  AUTHORS   Cheng C, Tian Y, Yang R, Guo W, Xiao K, Zhang F, Tian J, Deng Z,
            Yang W, Yang H and Zhou Z.
  TITLE     miR-5581 Contributes to Osteoarthritis by Targeting NRF1 to Disturb
            the Proliferation and Functions of Chondrocytes
  JOURNAL   Am J Pathol 193 (9), 1234-1247 (2023)
   PUBMED   37611970
  REMARK    GeneRIF: miR-5581 Contributes to Osteoarthritis by Targeting NRF1
            to Disturb the Proliferation and Functions of Chondrocytes.
REFERENCE   2  (residues 1 to 531)
  AUTHORS   Meng Z, Liang B, Wu Y, Liu C, Wang H, Du Y, Gan L, Gao E, Lau WB,
            Christopher TA, Lopez BL, Koch WJ, Ma X, Zhao F, Wang Y and Zhao J.
  TITLE     Hypoadiponectinemia-induced upregulation of microRNA449b
            downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury
            in diabetic mice
  JOURNAL   J Mol Cell Cardiol 182, 1-14 (2023)
   PUBMED   37437402
  REMARK    GeneRIF: Hypoadiponectinemia-induced upregulation of microRNA449b
            downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury
            in diabetic mice.
REFERENCE   3  (residues 1 to 531)
  AUTHORS   Zhao T, Zhang J, Lei H, Meng Y, Cheng H, Zhao Y, Geng G, Mu C, Chen
            L, Liu Q, Luo Q, Zhang C, Long Y, Su J, Wang Y, Li Z, Sun J, Chen
            G, Li Y, Liao X, Shang Y, Hu G, Chen Q and Zhu Y.
  TITLE     NRF1-mediated mitochondrial biogenesis antagonizes innate antiviral
            immunity
  JOURNAL   EMBO J 42 (16), e113258 (2023)
   PUBMED   37409632
  REMARK    GeneRIF: NRF1-mediated mitochondrial biogenesis antagonizes innate
            antiviral immunity.
REFERENCE   4  (residues 1 to 531)
  AUTHORS   Akl MG, Baccetto R, Stebbings BM, Li L and Widenmaier SB.
  TITLE     Euglycemia is affected by stress defense factor hepatocyte NRF1,
            but not NRF2
  JOURNAL   Biochem Biophys Res Commun 668, 96-103 (2023)
   PUBMED   37245295
  REMARK    GeneRIF: Euglycemia is affected by stress defense factor hepatocyte
            NRF1, but not NRF2.
REFERENCE   5  (residues 1 to 531)
  AUTHORS   Akl MG, Li L, Baccetto R, Phanse S, Zhang Q, Trites MJ, McDonald S,
            Aoki H, Babu M and Widenmaier SB.
  TITLE     Complementary gene regulation by NRF1 and NRF2 protects against
            hepatic cholesterol overload
  JOURNAL   Cell Rep 42 (4), 112399 (2023)
   PUBMED   37060561
  REMARK    GeneRIF: Complementary gene regulation by NRF1 and NRF2 protects
            against hepatic cholesterol overload.
            Erratum:[Cell Rep. 2023 Jul 25;42(7):112872. PMID: 37454293]
REFERENCE   6  (residues 1 to 531)
  AUTHORS   Carmona MC, Iglesias R, Obregon MJ, Darlington GJ, Villarroya F and
            Giralt M.
  TITLE     Mitochondrial biogenesis and thyroid status maturation in brown fat
            require CCAAT/enhancer-binding protein alpha
  JOURNAL   J Biol Chem 277 (24), 21489-21498 (2002)
   PUBMED   11940593
REFERENCE   7  (residues 1 to 531)
  AUTHORS   Huo L and Scarpulla RC.
  TITLE     Mitochondrial DNA instability and peri-implantation lethality
            associated with targeted disruption of nuclear respiratory factor 1
            in mice
  JOURNAL   Mol Cell Biol 21 (2), 644-654 (2001)
   PUBMED   11134350
REFERENCE   8  (residues 1 to 531)
  AUTHORS   Schaefer L, Engman H and Miller JB.
  TITLE     Coding sequence, chromosomal localization, and expression pattern
            of Nrf1: the mouse homolog of Drosophila erect wing
  JOURNAL   Mamm Genome 11 (2), 104-110 (2000)
   PUBMED   10656923
REFERENCE   9  (residues 1 to 531)
  AUTHORS   Huo L and Scarpulla RC.
  TITLE     Multiple 5'-untranslated exons in the nuclear respiratory factor 1
            gene span 47 kb and contribute to transcript heterogeneity and
            translational efficiency
  JOURNAL   Gene 233 (1-2), 213-224 (1999)
   PUBMED   10375638
REFERENCE   10 (residues 1 to 531)
  AUTHORS   Virbasius CA, Virbasius JV and Scarpulla RC.
  TITLE     NRF-1, an activator involved in nuclear-mitochondrial interactions,
            utilizes a new DNA-binding domain conserved in a family of
            developmental regulators
  JOURNAL   Genes Dev 7 (12A), 2431-2445 (1993)
   PUBMED   8253388
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134897.4 and AC153632.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422592.416489.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..531
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 12.47 cM"
     Protein         1..531
                     /product="nuclear respiratory factor 1 isoform d"
                     /note="NRF-1; alpha-pal; alpha palindromic-binding
                     protein"
                     /calculated_mol_wt=56962
     Region          87..295
                     /region_name="Nrf1_DNA-bind"
                     /note="NLS-binding and DNA-binding and dimerization
                     domains of Nrf1; pfam10491"
                     /db_xref="CDD:402218"
     CDS             1..531
                     /gene="Nrf1"
                     /gene_synonym="D6Ertd415e"
                     /coded_by="NM_001410225.1:274..1869"
                     /note="isoform d is encoded by transcript variant 15"
                     /db_xref="GeneID:18181"
                     /db_xref="MGI:MGI:1332235"
ORIGIN      
        1 meehgvtqte hmatieahav aqqvqqvhva tytehsmlsa dedspssped tsyddsdiln
       61 staadevtah laaavlgikp rashilgpvg maaaaavatg kkrkrphvfe snpsirkrqq
      121 trllrklrat ldeyttrvgq qaivlcisps kpnpvfkvfg aaplenvvrk yksmiledle
      181 salaehapap qevnselppl tidgipvsvd kmtqaqlraf ipemlkystg rgkpgwgkes
      241 ckpiwwpedi pwanvrsdvr teeqkqrvsw tqalrtivkn cykqhgredl lyafedqqtq
      301 tqattthsia hlvpsqtvvq tfsnpdgtvs liqvgtgatv atladaselp ttvtvaqvny
      361 savadgeveq nwatlqggem tiqttqasea tqavaslaea avaasqemqq gatvtmalns
      421 eaaahavatl aeatlqgggq ivlsgetaaa vgaltgvqda nglgspvlpe imasktrgyr
      481 hscgrdlyrl fsffllyskn nerillapat sgspcfyvrn iitirvgils s
//
LOCUS       NP_033786                519 aa            linear   ROD 09-OCT-2023
DEFINITION  aldehyde dehydrogenase, mitochondrial isoform 1 precursor [Mus
            musculus].
ACCESSION   NP_033786
VERSION     NP_033786.1
DBSOURCE    REFSEQ: accession NM_009656.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 519)
  AUTHORS   Qu Y, Liu Y and Zhang H.
  TITLE     ALDH2 activation attenuates oxygen-glucose
            deprivation/reoxygenation-induced cell apoptosis, pyroptosis,
            ferroptosis and autophagy
  JOURNAL   Clin Transl Oncol 25 (11), 3203-3216 (2023)
   PUBMED   37103763
  REMARK    GeneRIF: ALDH2 activation attenuates oxygen-glucose
            deprivation/reoxygenation-induced cell apoptosis, pyroptosis,
            ferroptosis and autophagy.
REFERENCE   2  (residues 1 to 519)
  AUTHORS   Chang YC, Lee HL, Yang W, Hsieh ML, Liu CC, Lee TY, Huang JY, Nong
            JY, Li FA, Chuang HL, Ding ZZ, Su WL, Chueh LY, Tsai YT, Chen CH,
            Mochly-Rosen D and Chuang LM.
  TITLE     A common East-Asian ALDH2 mutation causes metabolic disorders and
            the therapeutic effect of ALDH2 activators
  JOURNAL   Nat Commun 14 (1), 5971 (2023)
   PUBMED   37749090
  REMARK    GeneRIF: A common East-Asian ALDH2 mutation causes metabolic
            disorders and the therapeutic effect of ALDH2 activators.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 519)
  AUTHORS   Wang L, Tian M, Li R, Wu Y, Wang S, Lu H, Liu Z and Yu Y.
  TITLE     [Acetaldehyde dehydrogenase 2 ameliorates lung endothelial barrier
            and balances mitochondrial dynamics in mice with acute lung injury]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 43 (8), 1388-1395 (2023)
   PUBMED   37712276
  REMARK    GeneRIF: [Acetaldehyde dehydrogenase 2 ameliorates lung endothelial
            barrier and balances mitochondrial dynamics in mice with acute lung
            injury].
REFERENCE   4  (residues 1 to 519)
  AUTHORS   Wang M, Brandt LTL, Wang X, Russell H, Mitchell E, Kamimae-Lanning
            AN, Brown JM, Dingler FA, Garaycoechea JI, Isobe T, Kinston SJ, Gu
            M, Vassiliou GS, Wilson NK, Gottgens B and Patel KJ.
  TITLE     Genotoxic aldehyde stress prematurely ages hematopoietic stem cells
            in a p53-driven manner
  JOURNAL   Mol Cell 83 (14), 2417-2433 (2023)
   PUBMED   37348497
REFERENCE   5  (residues 1 to 519)
  AUTHORS   Lee AS, Sung YL, Pan SH, Sung KT, Su CH, Ding SL, Lu YJ, Hsieh CL,
            Chen YF, Liu CC, Chen WY, Chen XR, Chung FP, Wang SW, Chen CH,
            Mochly-Rosen D, Hung CL, Yeh HI and Lin SF.
  TITLE     A Common East Asian aldehyde dehydrogenase 2*2 variant promotes
            ventricular arrhythmia with chronic light-to-moderate alcohol use
            in mice
  JOURNAL   Commun Biol 6 (1), 610 (2023)
   PUBMED   37280327
  REMARK    GeneRIF: A Common East Asian aldehyde dehydrogenase 2*2 variant
            promotes ventricular arrhythmia with chronic light-to-moderate
            alcohol use in mice.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 519)
  AUTHORS   Fijneman RJ and Demant P.
  TITLE     A gene for susceptibility to small intestinal cancer, ssic1, maps
            to the distal part of mouse chromosome 4
  JOURNAL   Cancer Res 55 (14), 3179-3182 (1995)
   PUBMED   7606739
REFERENCE   7  (residues 1 to 519)
  AUTHORS   Chang C and Yoshida A.
  TITLE     Cloning and characterization of the gene encoding mouse
            mitochondrial aldehyde dehydrogenase
  JOURNAL   Gene 148 (2), 331-336 (1994)
   PUBMED   7958964
REFERENCE   8  (residues 1 to 519)
  AUTHORS   Caubin J, Iglesias T, Bernal J, Munoz A, Marquez G, Barbero JL and
            Zaballos A.
  TITLE     Isolation of genomic DNA fragments corresponding to genes modulated
            in vivo by a transcription factor
  JOURNAL   Nucleic Acids Res 22 (20), 4132-4138 (1994)
   PUBMED   7937138
REFERENCE   9  (residues 1 to 519)
  AUTHORS   Chen M, Achkar C and Gudas LJ.
  TITLE     Enzymatic conversion of retinaldehyde to retinoic acid by cloned
            murine cytosolic and mitochondrial aldehyde dehydrogenases
  JOURNAL   Mol Pharmacol 46 (1), 88-96 (1994)
   PUBMED   8058062
REFERENCE   10 (residues 1 to 519)
  AUTHORS   McCaffery P, Tempst P, Lara G and Drager UC.
  TITLE     Aldehyde dehydrogenase is a positional marker in the retina
  JOURNAL   Development 112 (3), 693-702 (1991)
   PUBMED   1935685
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK165032.1, AK163452.1 and AW050084.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK163452.1, AK165032.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..519
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 61.86 cM"
     Protein         1..519
                     /product="aldehyde dehydrogenase, mitochondrial isoform 1
                     precursor"
                     /EC_number="1.2.1.3"
                     /note="aldehyde dehydrogenase, mitochondrial; ALDH class
                     2"
                     /calculated_mol_wt=54375
     transit_peptide 1..19
                     /note="Mitochondrion. /evidence=ECO:0000250; propagated
                     from UniProtKB/Swiss-Prot (P47738.1)"
                     /calculated_mol_wt=2181
     Region          33..513
                     /region_name="ALDH_F1AB_F2_RALDH1"
                     /note="NAD+-dependent retinal dehydrogenase 1, ALDH
                     families 1A, 1B, and 2-like; cd07141"
                     /db_xref="CDD:143459"
     Site            54
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P47738.1)"
     Site            75
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P47738.1)"
     Site            80
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P47738.1)"
     Site            order(91..92,96,99,101,105,146,149..150,154,156..157,
                     160..164,166..167,170..177,270,273,276..277,280..281,283,
                     288,453,455,462,465,467..474,481..483,486..489,491,494,
                     499,506..511,513)
                     /site_type="other"
                     /note="homotetrameric interface [polypeptide binding]"
                     /db_xref="CDD:143459"
     Site            161
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P47738.1)"
     Site            order(184..187,211,214,244,248..249,262,265,268,288..289,
                     321,368,371,418)
                     /site_type="other"
                     /note="NAD binding site [chemical binding]"
                     /db_xref="CDD:143459"
     Site            order(188,287,318,321)
                     /site_type="active"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:143459"
     Site            188
                     /site_type="other"
                     /note="Transition state stabilizer.
                     /evidence=ECO:0000250|UniProtKB:P20000; propagated from
                     UniProtKB/Swiss-Prot (P47738.1)"
     Site            370
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P47738.1)"
     Site            377
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P47738.1)"
     Site            385
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P47738.1)"
     Site            409
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P47738.1)"
     Site            428
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P47738.1)"
     Site            430
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753,
                     ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P47738.1)"
     Site            443
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P47738.1)"
     Site            453
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23576753; propagated from
                     UniProtKB/Swiss-Prot (P47738.1)"
     CDS             1..519
                     /gene="Aldh2"
                     /gene_synonym="Ahd-5; AHD-M1; Ahd5; ALDH-E2; ALDHI"
                     /coded_by="NM_009656.4:344..1903"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS19638.1"
                     /db_xref="GeneID:11669"
                     /db_xref="MGI:MGI:99600"
ORIGIN      
        1 mlraalttvr rgprlsrlls aaatsavpap nhqpevfcnq ifinnewhda vsrktfptvn
       61 pstgevicqv aegnkedvdk avkaaraafq lgspwrrmda sdrgrllyrl adlierdrty
      121 laaletldng kpyvisylvd ldmvlkclry yagwadkyhg ktipidgdff sytrhepvgv
      181 cgqiipwnfp llmqawklgp alatgnvvvm kvaeqtplta lyvanlikea gfppgvvniv
      241 pgfgptagaa iashegvdkv aftgstevgh liqvaagssn lkrvtlelgg kspniimsda
      301 dmdwaveqah falffnqgqc ccagsrtfvq envydefver svaraksrvv gnpfdsrteq
      361 gpqvdetqfk kilgyiksgq qegakllcgg gaaadrgyfi qptvfgdvkd gmtiakeeif
      421 gpvmqilkfk tieevvgran dskyglaaav ftkdldkany lsqalqagtv wincydvfga
      481 qspfggykms gsgrelgeyg lqaytevktv tvkvpqkns
//
LOCUS       NP_001405794             224 aa            linear   ROD 09-OCT-2023
DEFINITION  DDRGK domain-containing protein 1 isoform b [Mus musculus].
ACCESSION   NP_001405794
VERSION     NP_001405794.1
DBSOURCE    REFSEQ: accession NM_001418865.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 224)
  AUTHORS   Yang X, Zhou T, Wang X, Xia Y, Cao X, Cheng X, Cao Y, Ma P, Ma H,
            Qin A and Zhao J.
  TITLE     Loss of DDRGK1 impairs IRE1alpha UFMylation in spondyloepiphyseal
            dysplasia
  JOURNAL   Int J Biol Sci 19 (15), 4709-4725 (2023)
   PUBMED   37781516
  REMARK    GeneRIF: Loss of DDRGK1 impairs IRE1alpha UFMylation in
            spondyloepiphyseal dysplasia.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 224)
  AUTHORS   Tandra V, Anderson T, Ayala JD, Weintraub NL, Singh N, Li H and Li
            J.
  TITLE     Ufmylation of UFBP1 Is Dispensable for Endoplasmic Reticulum Stress
            Response, Embryonic Development, and Cardiac and Intestinal
            Homeostasis
  JOURNAL   Cells 12 (15), 1923 (2023)
   PUBMED   37566002
  REMARK    GeneRIF: Ufmylation of UFBP1 Is Dispensable for Endoplasmic
            Reticulum Stress Response, Embryonic Development, and Cardiac and
            Intestinal Homeostasis.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 224)
  AUTHORS   Chen F, Sheng L, Zhou T, Yan L, Loveless R, Li H, Teng Y and Cai Y.
  TITLE     Loss of Ufl1/Ufbp1 in hepatocytes promotes liver pathological
            damage and carcinogenesis through activating mTOR signaling
  JOURNAL   J Exp Clin Cancer Res 42 (1), 110 (2023)
   PUBMED   37131258
  REMARK    GeneRIF: Loss of Ufl1/Ufbp1 in hepatocytes promotes liver
            pathological damage and carcinogenesis through activating mTOR
            signaling.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 224)
  AUTHORS   Li H, Yu Z, Niu Z, Cheng Y, Wei Z, Cai Y, Ma F, Hu L, Zhu J and
            Zhang W.
  TITLE     A neuroprotective role of Ufmylation through Atg9 in the aging
            brain of Drosophila
  JOURNAL   Cell Mol Life Sci 80 (5), 129 (2023)
   PUBMED   37086384
  REMARK    GeneRIF: A neuroprotective role of Ufmylation through Atg9 in the
            aging brain of Drosophila.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 224)
  AUTHORS   Weisz-Hubshman M, Egunsula AT, Dawson B, Castellon A, Jiang MM,
            Chen-Evenson Y, Zhiyin Y, Lee B and Bae Y.
  TITLE     DDRGK1 is required for the proper development and maintenance of
            the growth plate cartilage
  JOURNAL   Hum Mol Genet 31 (16), 2820-2830 (2022)
   PUBMED   35377455
REFERENCE   6  (residues 1 to 224)
  AUTHORS   Yoo HM, Kang SH, Kim JY, Lee JE, Seong MW, Lee SW, Ka SH, Sou YS,
            Komatsu M, Tanaka K, Lee ST, Noh DY, Baek SH, Jeon YJ and Chung CH.
  TITLE     Modification of ASC1 by UFM1 is crucial for ERalpha transactivation
            and breast cancer development
  JOURNAL   Mol Cell 56 (2), 261-274 (2014)
   PUBMED   25219498
REFERENCE   7  (residues 1 to 224)
  AUTHORS   Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H,
            Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T,
            Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P,
            Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ,
            Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD,
            Flicek P, Skarnes WC, Mallon AM and Parkinson H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (residues 1 to 224)
  AUTHORS   Lemaire K, Moura RF, Granvik M, Igoillo-Esteve M, Hohmeier HE,
            Hendrickx N, Newgard CB, Waelkens E, Cnop M and Schuit F.
  TITLE     Ubiquitin fold modifier 1 (UFM1) and its target UFBP1 protect
            pancreatic beta cells from ER stress-induced apoptosis
  JOURNAL   PLoS One 6 (4), e18517 (2011)
   PUBMED   21494687
  REMARK    GeneRIF: These data suggest that UFM1-UFBP1 participate in
            preventing endoplasmic reticulum stress-induced apoptosis in
            protein secretory cells.
            Publication Status: Online-Only
REFERENCE   9  (residues 1 to 224)
  AUTHORS   Wu J, Lei G, Mei M, Tang Y and Li H.
  TITLE     A novel C53/LZAP-interacting protein regulates stability of
            C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and
            modulates NF-kappaB signaling
  JOURNAL   J Biol Chem 285 (20), 15126-15136 (2010)
   PUBMED   20228063
REFERENCE   10 (residues 1 to 224)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL772162.4 and AL731707.12.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.4225325.1,
                                           SRR17784643.794476.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..224
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 63.24 cM"
     Protein         1..224
                     /product="DDRGK domain-containing protein 1 isoform b"
                     /note="DDRGK domain-containing protein 1; UFM1-binding
                     protein 1 containing a PCI domain; UFM1-binding and PCI
                     domain-containing protein 1"
                     /calculated_mol_wt=26041
     Region          25..213
                     /region_name="DDRGK"
                     /note="DDRGK domain; pfam09756"
                     /db_xref="CDD:370664"
     CDS             1..224
                     /gene="Ddrgk1"
                     /gene_synonym="1110001I20Rik; 2600009E05Rik; Ufbp1"
                     /coded_by="NM_001418865.1:324..998"
                     /note="isoform b is encoded by transcript variant 2"
                     /db_xref="GeneID:77006"
                     /db_xref="MGI:MGI:1924256"
ORIGIN      
        1 mrmwvkllfq eeegiekpae vhptgkigak klrkleekqa rkaqreaeea ereerkrles
       61 qreaewkkee erlrlkeeqk eeeerkaqee qarreheeyl klkeafvvee egvsetmtee
      121 qshsfltefi nyikkskvvl ledlafqmgl rtqdainriq dlltegtltg viddrgkfiy
      181 itpeelaava nfirqrgrvs itelaqasns liswgqdlpa qasa
//
LOCUS       NP_035740                474 aa            linear   ROD 09-OCT-2023
DEFINITION  tumor necrosis factor receptor superfamily member 1B precursor [Mus
            musculus].
ACCESSION   NP_035740
VERSION     NP_035740.2
DBSOURCE    REFSEQ: accession NM_011610.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 474)
  AUTHORS   Khan AUH, Ali AK, Marr B, Jo D, Ahmadvand S, Fong-McMaster C,
            Almutairi SM, Wang L, Sad S, Harper ME and Lee SH.
  TITLE     The TNFalpha/TNFR2 axis mediates natural killer cell proliferation
            by promoting aerobic glycolysis
  JOURNAL   Cell Mol Immunol 20 (10), 1140-1155 (2023)
   PUBMED   37553427
  REMARK    GeneRIF: The TNFalpha/TNFR2 axis mediates natural killer cell
            proliferation by promoting aerobic glycolysis.
REFERENCE   2  (residues 1 to 474)
  AUTHORS   Gao Y, Shi H, Zhao H, Yao M, He Y, Jiang M, Li J, Li Z, Su S, Liu
            T, Yin C, Liao X and Yue W.
  TITLE     Single-cell transcriptomics identify TNFRSF1B as a novel T-cell
            exhaustion marker for ovarian cancer
  JOURNAL   Clin Transl Med 13 (9), e1416 (2023)
   PUBMED   37712139
  REMARK    GeneRIF: Single-cell transcriptomics identify TNFRSF1B as a novel
            T-cell exhaustion marker for ovarian cancer.
REFERENCE   3  (residues 1 to 474)
  AUTHORS   Dutta P and Bishayi B.
  TITLE     IL-10 in combination with IL-12 and TNF-alpha attenuates
            CXCL8/CXCR1 axis in peritoneal macrophages of mice infected with
            Staphylococcus aureus through the TNFR1-IL-1R-NF-kappaB pathway
  JOURNAL   Int Immunopharmacol 120, 110297 (2023)
   PUBMED   37207443
  REMARK    GeneRIF: IL-10 in combination with IL-12 and TNF-alpha attenuates
            CXCL8/CXCR1 axis in peritoneal macrophages of mice infected with
            Staphylococcus aureus through the TNFR1-IL-1R-NF-kappaB pathway.
REFERENCE   4  (residues 1 to 474)
  AUTHORS   Lin S, Xu C, Yin X, Tian H and Mei X.
  TITLE     Aging and TNF induce premature senescence of astrocytes after
            spinal cord injury via regulating YAP expression
  JOURNAL   Int Immunopharmacol 120, 110276 (2023)
   PUBMED   37182448
  REMARK    GeneRIF: Aging and TNF induce premature senescence of astrocytes
            after spinal cord injury via regulating YAP expression.
REFERENCE   5  (residues 1 to 474)
  AUTHORS   Pegoretti V, Bauer J, Fischer R, Paro I, Douwenga W, Kontermann RE,
            Pfizenmaier K, Houben E, Broux B, Hellings N, Baron W, Laman JD and
            Eisel ULM.
  TITLE     Sequential treatment with a TNFR2 agonist and a TNFR1 antagonist
            improves outcomes in a humanized mouse model for MS
  JOURNAL   J Neuroinflammation 20 (1), 106 (2023)
   PUBMED   37138340
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 474)
  AUTHORS   Brownell E, Ranges GE, Sarr T, Fiorentino L, Godfrey M, Pekar S,
            Hart J, Kamarck M, Rae PM, Ruddle FH et al.
  TITLE     Chromosome assignments of the human TNF p55 and p75 receptor genes
  JOURNAL   J Exp Zool 262 (3), 340-342 (1992)
   PUBMED   1322446
REFERENCE   7  (residues 1 to 474)
  AUTHORS   Milatovich A, Song K, Heller RA and Francke U.
  TITLE     Tumor necrosis factor receptor genes, TNFR1 and TNFR2, on human
            chromosomes 12 and 1
  JOURNAL   Somat Cell Mol Genet 17 (5), 519-523 (1991)
   PUBMED   1662415
REFERENCE   8  (residues 1 to 474)
  AUTHORS   Goodwin RG, Anderson D, Jerzy R, Davis T, Brannan CI, Copeland NG,
            Jenkins NA and Smith CA.
  TITLE     Molecular cloning and expression of the type 1 and type 2 murine
            receptors for tumor necrosis factor
  JOURNAL   Mol Cell Biol 11 (6), 3020-3026 (1991)
   PUBMED   1645445
REFERENCE   9  (residues 1 to 474)
  AUTHORS   Lewis M, Tartaglia LA, Lee A, Bennett GL, Rice GC, Wong GH, Chen EY
            and Goeddel DV.
  TITLE     Cloning and expression of cDNAs for two distinct murine tumor
            necrosis factor receptors demonstrate one receptor is species
            specific
  JOURNAL   Proc Natl Acad Sci U S A 88 (7), 2830-2834 (1991)
   PUBMED   1849278
REFERENCE   10 (residues 1 to 474)
  AUTHORS   Rothe JG, Brockhaus M, Gentz R and Lesslauer W.
  TITLE     Molecular cloning and expression of the mouse Tnf receptor type b
  JOURNAL   Immunogenetics 34 (5), 338-340 (1991)
   PUBMED   1657766
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK140332.1 and BY489212.1.
            
            On Jul 13, 2005 this sequence version replaced NP_035740.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK140332.1, AK004844.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 78.17 cM"
     Protein         1..474
                     /product="tumor necrosis factor receptor superfamily
                     member 1B precursor"
                     /note="TNF-RII; TNFR-II; p80 TNF-alpha receptor; tumor
                     necrosis factor receptor 2; tumor necrosis factor receptor
                     type II; p75 TNFR; TNF receptor beta chain"
                     /calculated_mol_wt=48151
     sig_peptide     1..20
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=2188
     Site            30
                     /site_type="glycosylation"
                     /note="O-linked (GalNAc...) threonine.
                     /evidence=ECO:0000250|UniProtKB:P20333; propagated from
                     UniProtKB/Swiss-Prot (P25119.1)"
     Region          39..77
                     /region_name="TNFR-Cys 1"
                     /note="propagated from UniProtKB/Swiss-Prot (P25119.1)"
     Region          40..203
                     /region_name="TNFRSF1B"
                     /note="Tumor necrosis factor receptor superfamily member
                     1B (TNFRSF1B), also known as TNFR2; cd10577"
                     /db_xref="CDD:276903"
     Region          40..76
                     /region_name="CRD1"
                     /note="CRD1 [structural motif]"
                     /db_xref="CDD:276903"
     Site            69
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P25119.1)"
     Region          78..119
                     /region_name="TNFR-Cys 2"
                     /note="propagated from UniProtKB/Swiss-Prot (P25119.1)"
     Region          79..119
                     /region_name="CRD2"
                     /note="CRD2 [structural motif]"
                     /db_xref="CDD:276903"
     Site            order(81,83,85..87,89..91,93..97,99..100,117,129,131..132,
                     137..138)
                     /site_type="other"
                     /note="polypeptide ligand binding site [polypeptide
                     binding]"
                     /db_xref="CDD:276903"
     Site            order(100..101,104,122,173..175,199,201)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:276903"
     Region          120..164
                     /region_name="TNFR-Cys 3"
                     /note="propagated from UniProtKB/Swiss-Prot (P25119.1)"
     Region          121..145
                     /region_name="CRD3"
                     /note="CRD3 [structural motif]"
                     /db_xref="CDD:276903"
     Region          163..203
                     /region_name="CRD4"
                     /note="CRD4 [structural motif]"
                     /db_xref="CDD:276903"
     Region          165..203
                     /region_name="TNFR-Cys 4"
                     /note="propagated from UniProtKB/Swiss-Prot (P25119.1)"
     Site            195
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P25119.1)"
     Region          <208..277
                     /region_name="COG3889"
                     /note="Predicted periplasmic protein [Function unknown]"
                     /db_xref="CDD:226406"
     Site            208
                     /site_type="glycosylation"
                     /note="O-linked (GalNAc...) threonine.
                     /evidence=ECO:0000250|UniProtKB:P20333; propagated from
                     UniProtKB/Swiss-Prot (P25119.1)"
     Region          220..243
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P25119.1)"
     Site            224
                     /site_type="glycosylation"
                     /note="O-linked (GalNAc...) threonine.
                     /evidence=ECO:0000250|UniProtKB:P20333; propagated from
                     UniProtKB/Swiss-Prot (P25119.1)"
     Site            259..288
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P25119.1)"
     Region          295..314
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P25119.1)"
     Region          321..378
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P25119.1)"
     Site            331
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P20333; propagated from
                     UniProtKB/Swiss-Prot (P25119.1)"
     Region          397..463
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P25119.1)"
     CDS             1..474
                     /gene="Tnfrsf1b"
                     /gene_synonym="CD120b; p75; TNF-alphaR2; TNF-R-II; TNF-R2;
                     TNF-R75; TNFalpha-R2; TNFBR; Tnfr-1; Tnfr2; TNFR80;
                     TNFRII"
                     /coded_by="NM_011610.3:70..1494"
                     /db_xref="CCDS:CCDS18914.1"
                     /db_xref="GeneID:21938"
                     /db_xref="MGI:MGI:1314883"
ORIGIN      
        1 mapaalwval vfelqlwatg htvpaqvvlt pykpepgyec qisqeyydrk aqmccakcpp
       61 gqyvkhfcnk tsdtvcadce asmytqvwnq frtclscsss cttdqveira ctkqqnrvca
      121 ceagrycalk thsgscrqcm rlskcgpgfg vassrapngn vlckacapgt fsdttsstdv
      181 crphricsil aipgnastda vcapesptls aiprtlyvsq peptrsqpld qepgpsqtps
      241 iltslgstpi ieqstkggis lpiglivgvt slgllmlglv nciilvqrkk kpsclqrdak
      301 vphvpdeksq davgleqqhl lttapsssss slessasagd rrappgghpq arvmaeaqgf
      361 qearassris dsshgshgth vnvtcivnvc sssdhssqcs sqasatvgdp dakpsaspkd
      421 eqvpfsqeec psqspcette tlqshekplp lgvpdmgmkp sqagwfdqia vkva
//
LOCUS       NP_001397202             168 aa            linear   ROD 09-OCT-2023
DEFINITION  pleiotrophin precursor [Mus musculus].
ACCESSION   NP_001397202
VERSION     NP_001397202.1
DBSOURCE    REFSEQ: accession NM_001410273.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 168)
  AUTHORS   Li H, Xu L, Jiang W, Qiu X, Xu H, Zhu F, Hu Y, Liang S, Cai C, Qiu
            W, Lu Z, Cui Y and Tang C.
  TITLE     Pleiotrophin ameliorates age-induced adult hippocampal neurogenesis
            decline and cognitive dysfunction
  JOURNAL   Cell Rep 42 (9), 113022 (2023)
   PUBMED   37610873
  REMARK    GeneRIF: Pleiotrophin ameliorates age-induced adult hippocampal
            neurogenesis decline and cognitive dysfunction.
REFERENCE   2  (residues 1 to 168)
  AUTHORS   Zhou Y, Li H, Liu X, Chi X, Gu Z, Cui B, Bergquist J, Wang B, Tian
            G, Yang C, Xu F and Mi J.
  TITLE     The Combination of Quantitative Proteomics and Systems Genetics
            Analysis Reveals that PTN Is Associated with Sleep-Loss-Induced
            Cognitive Impairment
  JOURNAL   J Proteome Res 22 (9), 2936-2949 (2023)
   PUBMED   37611228
  REMARK    GeneRIF: The Combination of Quantitative Proteomics and Systems
            Genetics Analysis Reveals that PTN Is Associated with
            Sleep-Loss-Induced Cognitive Impairment.
REFERENCE   3  (residues 1 to 168)
  AUTHORS   Ganguly D, Schmidt MO, Coleman M, Ngo TC, Sorrelle N, Dominguez
            ATA, Murimwa GZ, Toombs JE, Lewis C, Fang YV, Valdes-Mora F,
            Gallego-Ortega D, Wellstein A and Brekken RA.
  TITLE     Pleiotrophin drives a prometastatic immune niche in breast cancer
  JOURNAL   J Exp Med 220 (5) (2023)
   PUBMED   36828390
  REMARK    GeneRIF: Pleiotrophin drives a prometastatic immune niche in breast
            cancer.
REFERENCE   4  (residues 1 to 168)
  AUTHORS   Wang X, Zhou D, Zhou W, Liu J, Xue Q, Huang Y, Cheng C, Wang Y,
            Chang J, Wang P and Miao C.
  TITLE     Clematichinenoside AR inhibits the pathology of rheumatoid
            arthritis by blocking the circPTN/miR-145-5p/FZD4 signal axis
  JOURNAL   Int Immunopharmacol 113 (Pt A), 109376 (2022)
   PUBMED   36279670
  REMARK    GeneRIF: Clematichinenoside AR inhibits the pathology of rheumatoid
            arthritis by blocking the circPTN/miR-145-5p/FZD4 signal axis.
REFERENCE   5  (residues 1 to 168)
  AUTHORS   Drake KA, Chaney C, Patel M, Das A, Bittencourt J, Cohn M and
            Carroll TJ.
  TITLE     Transcription Factors YAP/TAZ and SRF Cooperate To Specify Renal
            Myofibroblasts in the Developing Mouse Kidney
  JOURNAL   J Am Soc Nephrol 33 (9), 1694-1707 (2022)
   PUBMED   35918150
  REMARK    Erratum:[J Am Soc Nephrol. 2023 Mar 1;34(3):515-516. PMID:
            36857501]
REFERENCE   6  (residues 1 to 168)
  AUTHORS   Li YS, Hoffman RM, Le Beau MM, Espinosa R 3rd, Jenkins NA, Gilbert
            DJ, Copeland NG and Deuel TF.
  TITLE     Characterization of the human pleiotrophin gene. Promoter region
            and chromosomal localization
  JOURNAL   J Biol Chem 267 (36), 26011-26016 (1992)
   PUBMED   1464612
REFERENCE   7  (residues 1 to 168)
  AUTHORS   Katoh K, Takeshita S, Sato M, Ito T and Amann E.
  TITLE     Genomic organization of the mouse OSF-1 gene
  JOURNAL   DNA Cell Biol 11 (10), 735-743 (1992)
   PUBMED   1457042
REFERENCE   8  (residues 1 to 168)
  AUTHORS   Nurcombe V, Fraser N, Herlaar E and Heath JK.
  TITLE     MK: a pluripotential embryonic stem-cell-derived neuroregulatory
            factor
  JOURNAL   Development 116 (4), 1175-1183 (1992)
   PUBMED   1295735
REFERENCE   9  (residues 1 to 168)
  AUTHORS   Li YS, Gurrieri M and Deuel TF.
  TITLE     Pleiotrophin gene expression is highly restricted and is regulated
            by platelet-derived growth factor
  JOURNAL   Biochem Biophys Res Commun 184 (1), 427-432 (1992)
   PUBMED   1373617
REFERENCE   10 (residues 1 to 168)
  AUTHORS   Naito A, Yoshikura H and Iwamoto A.
  TITLE     Similarity of the genomic structure between the two members in a
            new family of heparin-binding factors
  JOURNAL   Biochem Biophys Res Commun 183 (2), 701-707 (1992)
   PUBMED   1550576
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154019.3 and AC153902.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189670.127049.1,
                                           SRR7345562.4414398.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..168
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 15.48 cM"
     Protein         1..168
                     /product="pleiotrophin precursor"
                     /note="osteoblast-specific factor 1; heparin-binding
                     neutrophic factor; heparin-binding brain mitogen;
                     heparin-binding growth factor 8; heparin-binding
                     growth-associated molecule"
                     /calculated_mol_wt=15299
     sig_peptide     1..32
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=3588
     mat_peptide     33..168
                     /product="Pleiotrophin. /id=PRO_0000024660"
                     /note="propagated from UniProtKB/Swiss-Prot (P63089.1)"
                     /calculated_mol_wt=15299
     Region          47..131
                     /region_name="PTN_MK_N"
                     /note="PTN/MK heparin-binding protein family, N-terminal
                     domain; cl02505"
                     /db_xref="CDD:445801"
     Region          92..99
                     /region_name="Chondroitin sulfate binding.
                     /evidence=ECO:0000250|UniProtKB:P21246"
                     /note="propagated from UniProtKB/Swiss-Prot (P63089.1)"
     Region          123..131
                     /region_name="Chondroitin sulfate binding.
                     /evidence=ECO:0000250|UniProtKB:P21246"
                     /note="propagated from UniProtKB/Swiss-Prot (P63089.1)"
     Region          139..168
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P63089.1)"
     Region          147..168
                     /region_name="Chondroitin sulfate A binding.
                     /evidence=ECO:0000250|UniProtKB:P21246"
                     /note="propagated from UniProtKB/Swiss-Prot (P63089.1)"
     CDS             1..168
                     /gene="Ptn"
                     /gene_synonym="HARP; HB-GAM; HBBM; HBBN; HBGF-8; HBNF;
                     OSF; Osf-1; Osf1"
                     /coded_by="NM_001410273.1:92..598"
                     /db_xref="GeneID:19242"
                     /db_xref="MGI:MGI:97804"
ORIGIN      
        1 mssqqyqqqr rkfaaaflal ifilaavdta eagkkekpek kvkksdcgew qwsvcvptsg
       61 dcglgtregt rtgaeckqtm ktqrckipcn wkkqfgaeck yqfqawgecd lntalktrtg
      121 slkralhnad cqktvtiskp cgkltkpkpq aeskkkkkeg kkqekmld
//
LOCUS       NP_001039023             416 aa            linear   ROD 09-OCT-2023
DEFINITION  PRKCA-binding protein [Mus musculus].
ACCESSION   NP_001039023
VERSION     NP_001039023.1
DBSOURCE    REFSEQ: accession NM_001045558.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 416)
  AUTHORS   Birmingham EA, Wickens MM, Kirkland JM, Knouse MC, McGrath AG and
            Briand LA.
  TITLE     Circulating ovarian hormones interact with protein interacting with
            C kinase (PICK1) within the medial prefrontal cortex to influence
            cocaine seeking in female mice
  JOURNAL   Horm Behav 155, 105408 (2023)
   PUBMED   37541099
  REMARK    GeneRIF: Circulating ovarian hormones interact with protein
            interacting with C kinase (PICK1) within the medial prefrontal
            cortex to influence cocaine seeking in female mice.
REFERENCE   2  (residues 1 to 416)
  AUTHORS   Ramsakha N, Ojha P, Pal S, Routh S, Citri A and Bhattacharyya S.
  TITLE     A vital role for PICK1 in the differential regulation of
            metabotropic glutamate receptor internalization and synaptic AMPA
            receptor endocytosis
  JOURNAL   J Biol Chem 299 (6), 104837 (2023)
   PUBMED   37209824
  REMARK    GeneRIF: A vital role for PICK1 in the differential regulation of
            metabotropic glutamate receptor internalization and synaptic AMPA
            receptor endocytosis.
REFERENCE   3  (residues 1 to 416)
  AUTHORS   Du YQ, Shu CY, Zheng M, Xu WD, Sun Y, Shen L, Zhang C, Zhang YX,
            Wang QN, Li KQ, Chen BY, Hao K, Lyu JX and Wang Z.
  TITLE     Truncating PICK1 Variant Identified in Azoospermia Affected
            Mitochondrial Dysfunction in Knockout Mice
  JOURNAL   Curr Med Sci 43 (2), 313-323 (2023)
   PUBMED   36971977
  REMARK    GeneRIF: Truncating PICK1 Variant Identified in Azoospermia
            Affected Mitochondrial Dysfunction in Knockout Mice.
REFERENCE   4  (residues 1 to 416)
  AUTHORS   Zhu Z, Wang W, Gu C, Wang M and Yan Y.
  TITLE     The M1 muscarinic acetylcholine receptor regulates the surface
            expression of the AMPA receptor subunit GluA2 via PICK1
  JOURNAL   Psychopharmacology (Berl) 240 (1), 239-248 (2023)
   PUBMED   36564670
  REMARK    GeneRIF: The M1 muscarinic acetylcholine receptor regulates the
            surface expression of the AMPA receptor subunit GluA2 via PICK1.
REFERENCE   5  (residues 1 to 416)
  AUTHORS   Longatti A, Ponzoni L, Moretto E, Giansante G, Lattuada N, Colombo
            MN, Francolini M, Sala M, Murru L and Passafaro M.
  TITLE     Arhgap22 Disruption Leads to RAC1 Hyperactivity Affecting
            Hippocampal Glutamatergic Synapses and Cognition in Mice
  JOURNAL   Mol Neurobiol 58 (12), 6092-6110 (2021)
   PUBMED   34455539
REFERENCE   6  (residues 1 to 416)
  AUTHORS   Takeya R, Takeshige K and Sumimoto H.
  TITLE     Interaction of the PDZ domain of human PICK1 with class I
            ADP-ribosylation factors
  JOURNAL   Biochem Biophys Res Commun 267 (1), 149-155 (2000)
   PUBMED   10623590
REFERENCE   7  (residues 1 to 416)
  AUTHORS   Dev KK, Nishimune A, Henley JM and Nakanishi S.
  TITLE     The protein kinase C alpha binding protein PICK1 interacts with
            short but not long form alternative splice variants of AMPA
            receptor subunits
  JOURNAL   Neuropharmacology 38 (5), 635-644 (1999)
   PUBMED   10340301
REFERENCE   8  (residues 1 to 416)
  AUTHORS   Torres R, Firestein BL, Dong H, Staudinger J, Olson EN, Huganir RL,
            Bredt DS, Gale NW and Yancopoulos GD.
  TITLE     PDZ proteins bind, cluster, and synaptically colocalize with Eph
            receptors and their ephrin ligands
  JOURNAL   Neuron 21 (6), 1453-1463 (1998)
   PUBMED   9883737
REFERENCE   9  (residues 1 to 416)
  AUTHORS   Staudinger J, Lu J and Olson EN.
  TITLE     Specific interaction of the PDZ domain protein PICK1 with the COOH
            terminus of protein kinase C-alpha
  JOURNAL   J Biol Chem 272 (51), 32019-32024 (1997)
   PUBMED   9405395
REFERENCE   10 (residues 1 to 416)
  AUTHORS   Staudinger J, Zhou J, Burgess R, Elledge SJ and Olson EN.
  TITLE     PICK1: a perinuclear binding protein and substrate for protein
            kinase C isolated by the yeast two-hybrid system
  JOURNAL   J Cell Biol 128 (3), 263-271 (1995)
   PUBMED   7844141
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU698586.1, AK090155.1, AI893973.1 and AI385692.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Both variants 1 and 2 encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC048788.1, SRR1660815.40779.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..416
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 37.7 cM"
     Protein         1..416
                     /product="PRKCA-binding protein"
                     /note="protein kinase C-alpha-binding protein; protein
                     that interacts with C kinase 1"
                     /calculated_mol_wt=46396
     Region          19..99
                     /region_name="PDZ"
                     /note="Domain present in PSD-95, Dlg, and ZO-1/2;
                     smart00228"
                     /db_xref="CDD:214570"
     Site            order(32..35,37,86..87,90..91)
                     /site_type="other"
                     /note="protein binding site [polypeptide binding]"
                     /db_xref="CDD:238492"
     Site            82
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9NRD5; propagated from
                     UniProtKB/Swiss-Prot (Q62083.2)"
     Region          146..360
                     /region_name="BAR_PICK1"
                     /note="The Bin/Amphiphysin/Rvs (BAR) domain of Protein
                     Interacting with C Kinase 1; cd07659"
                     /db_xref="CDD:153343"
     Site            order(162..163,169,173,176,179..180,183,186..187,191,
                     193..194,197,200..201,206..207,209..210,213,217,326,
                     330..331,334..335,337..338,345..346,348..349)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:153343"
     Site            order(168,171,174..175,178..179,181..183,185..186,222,225,
                     229,232..233)
                     /site_type="active"
                     /note="putative Rac binding site [active]"
                     /db_xref="CDD:153343"
     Region          373..416
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q62083.2)"
     CDS             1..416
                     /gene="Pick1"
                     /gene_synonym="Prkcabp"
                     /coded_by="NM_001045558.1:253..1503"
                     /db_xref="CCDS:CCDS27635.1"
                     /db_xref="GeneID:18693"
                     /db_xref="MGI:MGI:894645"
ORIGIN      
        1 mfadldydie edklgiptvp gkvtlqkdaq nligisiggg aqycpclyiv qvfdntpaal
       61 dgtvaagdei tgvngksikg ktkvevakmi qevkgevtih ynklqadpkq gmsldivlkk
      121 vkhrlvenms sgtadalgls railcndglv krleelerta elykgmteht knllrafyel
      181 sqthrafgdv fsvigvrepq paaseafvkf adahrsiekf girllktikp mltdlntyln
      241 kaipdtrlti kkyldvkfey lsyclkvkem ddeeyscial geplyrvstg nyeyrlilrc
      301 rqeararfsq mrkdvlekme lldqkhvqdi vfqlqrfvst mskyyndcya vlqdadvfpi
      361 evdlahttla ygpnqgsftd geeedeeeed gaarevskda cgatgptdkg gswcds
//
LOCUS       NP_201584               1292 aa            linear   ROD 09-OCT-2023
DEFINITION  zinc finger protein 423 isoform 1 [Mus musculus].
ACCESSION   NP_201584 XP_917173 XP_927334 XP_927339 XP_927344
VERSION     NP_201584.2
DBSOURCE    REFSEQ: accession NM_033327.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1292)
  AUTHORS   Roth L, Johann K, Hones GS, Oelkrug R, Wagner L, Hoffmann A, Krohn
            K, Moeller LC, Weiner J, Heiker JT, Kloting N, Tonjes A, Stumvoll
            M, Bluher M, Mittag J and Krause K.
  TITLE     Thyroid hormones regulate Zfp423 expression in regionally distinct
            adipose depots through direct and cell-autonomous action
  JOURNAL   Cell Rep 42 (2), 112088 (2023)
   PUBMED   36753417
  REMARK    GeneRIF: Thyroid hormones regulate Zfp423 expression in regionally
            distinct adipose depots through direct and cell-autonomous action.
REFERENCE   2  (residues 1 to 1292)
  AUTHORS   Shao M, Zhang Q, Truong A, Shan B, Vishvanath L, Li L, Seale P and
            Gupta RK.
  TITLE     ZFP423 controls EBF2 coactivator recruitment and PPARgamma
            occupancy to determine the thermogenic plasticity of adipocytes
  JOURNAL   Genes Dev 35 (21-22), 1461-1474 (2021)
   PUBMED   34620682
  REMARK    GeneRIF: ZFP423 controls EBF2 coactivator recruitment and PPARgamma
            occupancy to determine the thermogenic plasticity of adipocytes.
REFERENCE   3  (residues 1 to 1292)
  AUTHORS   Han S, Okawa S, Wilkinson GA, Ghazale H, Adnani L, Dixit R, Tavares
            L, Faisal I, Brooks MJ, Cortay V, Zinyk D, Sivitilli A, Li S, Malik
            F, Ilnytskyy Y, Angarica VE, Gao J, Chinchalongporn V, Oproescu AM,
            Vasan L, Touahri Y, David LA, Raharjo E, Kim JW, Wu W, Rahmani W,
            Chan JA, Kovalchuk I, Attisano L, Kurrasch D, Dehay C, Swaroop A,
            Castro DS, Biernaskie J, Del Sol A and Schuurmans C.
  TITLE     Proneural genes define ground-state rules to regulate neurogenic
            patterning and cortical folding
  JOURNAL   Neuron 109 (18), 2847-2863 (2021)
   PUBMED   34407390
REFERENCE   4  (residues 1 to 1292)
  AUTHORS   Casoni F, Croci L, Vincenti F, Podini P, Riba M, Massimino L,
            Cremona O and Consalez GG.
  TITLE     ZFP423 regulates early patterning and multiciliogenesis in the
            hindbrain choroid plexus
  JOURNAL   Development 147 (22) (2020)
   PUBMED   33046507
  REMARK    GeneRIF: ZFP423 regulates early patterning and multiciliogenesis in
            the hindbrain choroid plexus.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1292)
  AUTHORS   Alcaraz WA, Liu Z, Valdes P, Chen E, Valdovino Gonzalez AG, Wade S,
            Wong C, Kim E, Chen HM, Ponn A, Concepcion D and Hamilton BA.
  TITLE     Strain-Dependent Modifier Genes Determine Survival in Zfp423 Mice
  JOURNAL   G3 (Bethesda) 10 (11), 4241-4247 (2020)
   PUBMED   32967895
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1292)
  AUTHORS   Warming S, Liu P, Suzuki T, Akagi K, Lindtner S, Pavlakis GN,
            Jenkins NA and Copeland NG.
  TITLE     Evi3, a common retroviral integration site in murine B-cell
            lymphoma, encodes an EBFAZ-related Kruppel-like zinc finger protein
  JOURNAL   Blood 101 (5), 1934-1940 (2003)
   PUBMED   12393497
REFERENCE   7  (residues 1 to 1292)
  AUTHORS   Okazaki N, Kikuno R, Ohara R, Inamoto S, Aizawa H, Yuasa S,
            Nakajima D, Nagase T, Ohara O and Koga H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   8  (residues 1 to 1292)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (residues 1 to 1292)
  AUTHORS   Araki K, Imaizumi T, Sekimoto T, Yoshinobu K, Yoshimuta J, Akizuki
            M, Miura K, Araki M and Yamamura K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   10 (residues 1 to 1292)
  AUTHORS   Tsai RY and Reed RR.
  TITLE     Cloning and functional characterization of Roaz, a zinc finger
            protein that interacts with O/E-1 to regulate gene expression:
            implications for olfactory neuronal development
  JOURNAL   J Neurosci 17 (11), 4159-4169 (1997)
   PUBMED   9151733
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ180174.1, AK122365.1, BU519630.1, BB788751.1 and BF021428.1.
            
            On or before Dec 7, 2005 this sequence version replaced
            XP_927334.1, XP_927339.1, XP_927344.1, XP_917173.1, NP_201584.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079586.1, AY256893.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1292
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 42.29 cM"
     Protein         1..1292
                     /product="zinc finger protein 423 isoform 1"
                     /note="early B-cell factor associated zinc finger protein;
                     olf1/EBF-associated zinc finger protein; smad- and
                     Olf-interacting zinc finger protein; zinc finger protein
                     104; early B-cell factor associated zinc finger
                     transcription factor"
                     /calculated_mol_wt=145221
     Region          1..21
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80TS5.2)"
     Region          33..70
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80TS5.2)"
     Site            55
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q2M1K9; propagated from
                     UniProtKB/Swiss-Prot (Q80TS5.2)"
     Site            58
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q2M1K9; propagated from
                     UniProtKB/Swiss-Prot (Q80TS5.2)"
     Region          95..125
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80TS5.2)"
     Region          148..168
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(153,155,157,159..160,163..164,167,181,183,187..188,
                     191..192,195,209,211,213,215..216,219..220,223)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          176..196
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          202..603
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          204..224
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          232..252
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          273..292
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          354..407
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80TS5.2)"
     Region          419..440
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(424,427,429,431..432,435..436,439,456,458,462..463,
                     466..467,474,495,497,499,501..502,505..506,509)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          451..475
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          490..509
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          598..635
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80TS5.2)"
     Site            612
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q2M1K9; propagated from
                     UniProtKB/Swiss-Prot (Q80TS5.2)"
     Region          672..692
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          702..723
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          730..751
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(735,737,739,741..742,745..746,749,765,767,771..772,
                     775..776,780,796,798,800,802..803,806..807,810)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          760..781
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          791..811
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          817..835
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          896..917
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          940..960
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          969..989
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            1062
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q2M1K9; propagated from
                     UniProtKB/Swiss-Prot (Q80TS5.2)"
     Region          1144..1171
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80TS5.2)"
     Region          1208..1228
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(1213,1215,1217,1219..1220,1223..1224,1227,1244,1246,
                     1250..1251,1254..1255,1259,1274,1276,1278,1280..1281,
                     1284..1285)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          1239..1260
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          1269..1285
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..1292
                     /gene="Zfp423"
                     /gene_synonym="ataxia1; Ebfaz; mKIAA0760; nur12; Roaz;
                     Zfp104; Znf423"
                     /coded_by="NM_033327.2:361..4239"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS52627.1"
                     /db_xref="GeneID:94187"
                     /db_xref="MGI:MGI:1891217"
ORIGIN      
        1 msrrkqakpr svkveegeas dfslawdssv aaagglegep ecdrktsral edrnsvtsqe
       61 erneddedve desiytcdhc qqdfesladl tdhrahrcpg dgdddpqlsw vasspsskdv
      121 asptqmigdg cdlglgeeeg gtglpypcqf cdksfirlsy lkrheqihsd klpfkctfcs
      181 rlfkhkrsrd rhiklhtgdk kyhcheceaa fsrsdhlkih lkthssskpf kcsvckrgfs
      241 stsslqshmq ahkknkehla ksekeakkdd fmcdycedtf sqteelekhv ltlhpqlsek
      301 adlqcihcpe vfvdestlla hihqahanqk hkcpmcpeqf ssvegvychl dshrqpdssn
      361 hsvspdpvlg svasmssatp dssasvergs tpdstlkplr gqkkmrddgq swpkvvyscp
      421 ycskrdftsl avleihlkti hadkpqqsht cqicldsmpt lynlnehvrk lhkshaypvm
      481 qfgnisafhc nycpemfadi nslqehirvs hcgpnanppd gnnaffcnqc smgfltessl
      541 tehiqqahcs vgstklespv vqptqsfmev yscpyctnsp ifgsilkltk hikenhknip
      601 lahskkskae qspvssdvev sspkrqrlsg sansisngey pcnqcdlkfs nfesfqthlk
      661 lhlelllrkq acpqckedfd sqesllqhlt vhymttsthy vcescdkqfs svddlqkhll
      721 dmhtfvlyhc tlcqevfdsk vsiqvhlavk hsnekkmyrc tacnwdfrke adlqvhvkhs
      781 hlgnpakahk cifcgetfst evelqchitt hskkyncrfc skafhavill ekhlrekhcv
      841 fdaaaengta ngvpptstkk aepadlqgml lknpeapnsh easeddvdas epmygcdicg
      901 aaytmevllq nhrlrdhnir pgeddgsrkk aefikgshkc nvcsrtffse nglrehlqth
      961 rgpakhymcp icgerfpsll tltehkvths ksldtgtcri ckmplqseee fiehcqmhpd
     1021 lrnsltgfrc vvcmqtvtst lelkihgtfh mqklagssaa sspngqglqk lykcalclke
     1081 frskqdlvrl dvnglpyglc agcmarsang qvgglappep adrpcaglrc pecnvkfesa
     1141 edleshmqvd hrdltpetsg prkgaqtspv prkktyqcik cqmtfenere iqihvanhmi
     1201 eeginheckl cnqmfdspak llchliehsf egmggtfkcp vcftvfvqan klqqhifavh
     1261 gqedkiydcs qcpqkfffqt elqnhtmsqh aq
//
LOCUS       NP_033735                247 aa            linear   ROD 09-OCT-2023
DEFINITION  adiponectin precursor [Mus musculus].
ACCESSION   NP_033735
VERSION     NP_033735.3
DBSOURCE    REFSEQ: accession NM_009605.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 247)
  AUTHORS   Fukuoka K, Mineo R, Kita S, Fukuda S, Okita T, Kawada-Horitani E,
            Iioka M, Fujii K, Kawada K, Fujishima Y, Nishizawa H, Maeda N and
            Shimomura I.
  TITLE     ER stress decreases exosome production through
            adiponectin/T-cadherin-dependent and -independent pathways
  JOURNAL   J Biol Chem 299 (9), 105114 (2023)
   PUBMED   37524131
  REMARK    GeneRIF: ER stress decreases exosome production through
            adiponectin/T-cadherin-dependent and -independent pathways.
REFERENCE   2  (residues 1 to 247)
  AUTHORS   Blandin A, Amosse J, Froger J, Hilairet G, Durcin M, Fizanne L,
            Ghesquiere V, Prieur X, Chaigneau J, Vergori L, Dray C, Pradere JP,
            Blandin S, Dupont J, Ducluzeau PH, Dubois S, Boursier J, Cariou B
            and Le Lay S.
  TITLE     Extracellular vesicles are carriers of adiponectin with
            insulin-sensitizing and anti-inflammatory properties
  JOURNAL   Cell Rep 42 (8), 112866 (2023)
   PUBMED   37605533
REFERENCE   3  (residues 1 to 247)
  AUTHORS   Takezaki D, Morizane S, Ikeda K, Iseki M, Sakamoto Y, Kawakami Y,
            Hashiguchi T, Shirakata Y, Nishina S and Mukai T.
  TITLE     Co-occurrence of non-alcoholic steatohepatitis exacerbates
            psoriasis associated with decreased adiponectin expression in a
            murine model
  JOURNAL   Front Immunol 14, 1214623 (2023)
   PUBMED   37646025
  REMARK    GeneRIF: Co-occurrence of non-alcoholic steatohepatitis exacerbates
            psoriasis associated with decreased adiponectin expression in a
            murine model.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 247)
  AUTHORS   Soh S, Han S, Ka HI, Mun SH, Kim W, Oh G and Yang Y.
  TITLE     Adiponectin affects the migration ability of bone marrow-derived
            mesenchymal stem cells via the regulation of hypoxia inducible
            factor 1alpha
  JOURNAL   Cell Commun Signal 21 (1), 158 (2023)
   PUBMED   37370133
  REMARK    GeneRIF: Adiponectin affects the migration ability of bone
            marrow-derived mesenchymal stem cells via the regulation of hypoxia
            inducible factor 1alpha.
            Erratum:[Cell Commun Signal. 2023 Aug 3;21(1):194. PMID: 37537609]
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 247)
  AUTHORS   Choubey M and Bora P.
  TITLE     Emerging Role of Adiponectin/AdipoRs Signaling in Choroidal
            Neovascularization, Age-Related Macular Degeneration, and Diabetic
            Retinopathy
  JOURNAL   Biomolecules 13 (6), 982 (2023)
   PUBMED   37371562
  REMARK    GeneRIF: Emerging Role of Adiponectin/AdipoRs Signaling in
            Choroidal Neovascularization, Age-Related Macular Degeneration, and
            Diabetic Retinopathy.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 247)
  AUTHORS   Das K, Lin Y, Widen E, Zhang Y and Scherer PE.
  TITLE     Chromosomal localization, expression pattern, and promoter analysis
            of the mouse gene encoding adipocyte-specific secretory protein
            Acrp30
  JOURNAL   Biochem Biophys Res Commun 280 (4), 1120-1129 (2001)
   PUBMED   11162643
REFERENCE   7  (residues 1 to 247)
  AUTHORS   Bogan JS and Lodish HF.
  TITLE     Two compartments for insulin-stimulated exocytosis in 3T3-L1
            adipocytes defined by endogenous ACRP30 and GLUT4
  JOURNAL   J Cell Biol 146 (3), 609-620 (1999)
   PUBMED   10444069
REFERENCE   8  (residues 1 to 247)
  AUTHORS   Shapiro L and Scherer PE.
  TITLE     The crystal structure of a complement-1q family protein suggests an
            evolutionary link to tumor necrosis factor
  JOURNAL   Curr Biol 8 (6), 335-338 (1998)
   PUBMED   9512423
REFERENCE   9  (residues 1 to 247)
  AUTHORS   Hu E, Liang P and Spiegelman BM.
  TITLE     AdipoQ is a novel adipose-specific gene dysregulated in obesity
  JOURNAL   J Biol Chem 271 (18), 10697-10703 (1996)
   PUBMED   8631877
REFERENCE   10 (residues 1 to 247)
  AUTHORS   Scherer PE, Williams S, Fogliano M, Baldini G and Lodish HF.
  TITLE     A novel serum protein similar to C1q, produced exclusively in
            adipocytes
  JOURNAL   J Biol Chem 270 (45), 26746-26749 (1995)
   PUBMED   7592907
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK134112.1.
            
            On Feb 15, 2006 this sequence version replaced NP_033735.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK134112.1, AK041214.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..247
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 13.96 cM"
     Protein         1..247
                     /product="adiponectin precursor"
                     /note="adipocyte, C1Q and collagen domain containing;
                     adipocyte complement related protein; adipocyte-specific
                     protein AdipoQ; 30 kDa adipocyte complement-related
                     protein; adipocyte complement-related 30 kDa protein;
                     adipocyte, C1q and collagen domain-containing protein;
                     adiponectin d"
                     /calculated_mol_wt=24921
     sig_peptide     1..17
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=1906
     Site            23
                     /site_type="glycosylation"
                     /note="O-linked (GalNAc...) threonine.
                     /evidence=ECO:0000305|PubMed:19855092; propagated from
                     UniProtKB/Swiss-Prot (Q60994.2)"
     Site            24
                     /site_type="glycosylation"
                     /note="O-linked (GalNAc...) threonine.
                     /evidence=ECO:0000305|PubMed:19855092; propagated from
                     UniProtKB/Swiss-Prot (Q60994.2)"
     Site            36
                     /site_type="hydroxylation"
                     /note="5-hydroxylysine.
                     /evidence=ECO:0000250|UniProtKB:Q3Y5Z3; propagated from
                     UniProtKB/Swiss-Prot (Q60994.2)"
     Region          44..105
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60994.2)"
     Site            47
                     /site_type="hydroxylation"
                     /note="4-hydroxyproline. /evidence=ECO:0000250; propagated
                     from UniProtKB/Swiss-Prot (Q60994.2)"
     Site            50
                     /site_type="hydroxylation"
                     /note="4-hydroxyproline. /evidence=ECO:0000250; propagated
                     from UniProtKB/Swiss-Prot (Q60994.2)"
     Region          54..110
                     /region_name="Collagen"
                     /note="Collagen triple helix repeat (20 copies);
                     pfam01391"
                     /db_xref="CDD:396114"
     Site            56
                     /site_type="hydroxylation"
                     /note="4-hydroxyproline. /evidence=ECO:0000250; propagated
                     from UniProtKB/Swiss-Prot (Q60994.2)"
     Site            68
                     /site_type="hydroxylation"
                     /note="5-hydroxylysine, alternate.
                     /evidence=ECO:0000269|PubMed:11912203,
                     ECO:0000269|PubMed:23209641; propagated from
                     UniProtKB/Swiss-Prot (Q60994.2)"
     Site            68
                     /site_type="glycosylation"
                     /note="O-linked (Gal...) hydroxylysine, alternate.
                     /evidence=ECO:0000269|PubMed:11912203,
                     ECO:0000269|PubMed:23209641; propagated from
                     UniProtKB/Swiss-Prot (Q60994.2)"
     Site            71
                     /site_type="hydroxylation"
                     /note="5-hydroxylysine, alternate.
                     /evidence=ECO:0000269|PubMed:11912203,
                     ECO:0000269|PubMed:23209641; propagated from
                     UniProtKB/Swiss-Prot (Q60994.2)"
     Site            71
                     /site_type="glycosylation"
                     /note="O-linked (Gal...) hydroxylysine, alternate.
                     /evidence=ECO:0000269|PubMed:11912203,
                     ECO:0000269|PubMed:23209641; propagated from
                     UniProtKB/Swiss-Prot (Q60994.2)"
     Site            79
                     /site_type="other"
                     /note="Not hydroxylated.
                     /evidence=ECO:0000269|PubMed:11912203; propagated from
                     UniProtKB/Swiss-Prot (Q60994.2)"
     Site            80
                     /site_type="hydroxylation"
                     /note="5-hydroxylysine, alternate.
                     /evidence=ECO:0000269|PubMed:11912203,
                     ECO:0000269|PubMed:23209641; propagated from
                     UniProtKB/Swiss-Prot (Q60994.2)"
     Site            80
                     /site_type="glycosylation"
                     /note="O-linked (Gal...) hydroxylysine, alternate.
                     /evidence=ECO:0000269|PubMed:11912203,
                     ECO:0000269|PubMed:23209641; propagated from
                     UniProtKB/Swiss-Prot (Q60994.2)"
     Site            94
                     /site_type="hydroxylation"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000269|PubMed:11912203; propagated from
                     UniProtKB/Swiss-Prot (Q60994.2)"
     Site            98
                     /site_type="other"
                     /note="Not hydroxylated.
                     /evidence=ECO:0000269|PubMed:11912203; propagated from
                     UniProtKB/Swiss-Prot (Q60994.2)"
     Site            104
                     /site_type="hydroxylation"
                     /note="5-hydroxylysine, alternate.
                     /evidence=ECO:0000269|PubMed:11912203,
                     ECO:0000269|PubMed:23209641; propagated from
                     UniProtKB/Swiss-Prot (Q60994.2)"
     Site            104
                     /site_type="glycosylation"
                     /note="O-linked (Gal...) hydroxylysine, alternate.
                     /evidence=ECO:0000269|PubMed:11912203,
                     ECO:0000269|PubMed:23209641; propagated from
                     UniProtKB/Swiss-Prot (Q60994.2)"
     Site            107
                     /site_type="other"
                     /note="Not hydroxylated.
                     /evidence=ECO:0000269|PubMed:11912203; propagated from
                     UniProtKB/Swiss-Prot (Q60994.2)"
     Region          112..245
                     /region_name="C1Q"
                     /note="Complement component C1q domain; smart00110"
                     /db_xref="CDD:128420"
     Site            233
                     /site_type="other"
                     /note="Not glycosylated.
                     /evidence=ECO:0000269|PubMed:11912203; propagated from
                     UniProtKB/Swiss-Prot (Q60994.2)"
     CDS             1..247
                     /gene="Adipoq"
                     /gene_synonym="30kDa; Acdc; Acrp30; Ad; Adid; adipo; apM1;
                     APN; GBP28"
                     /coded_by="NM_009605.5:115..858"
                     /db_xref="CCDS:CCDS28075.1"
                     /db_xref="GeneID:11450"
                     /db_xref="MGI:MGI:106675"
ORIGIN      
        1 mlllqallfl lilpshaedd vttteelapa lvpppkgtca gwmagipghp ghngtpgrdg
       61 rdgtpgekge kgdagllgpk getgdvgmtg aegprgfpgt pgrkgepgea ayvyrsafsv
      121 gletrvtvpn vpirftkify nqqnhydgst gkfycnipgl yyfsyhitvy mkdvkvslfk
      181 kdkavlftyd qyqeknvdqa sgsvllhlev gdqvwlqvyg dgdhnglyad nvndstftgf
      241 llyhdtn
//
LOCUS       NP_033905                169 aa            linear   ROD 09-OCT-2023
DEFINITION  translocator protein [Mus musculus].
ACCESSION   NP_033905
VERSION     NP_033905.3
DBSOURCE    REFSEQ: accession NM_009775.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 169)
  AUTHORS   Rodriguez-Lopez A, Torres-Paniagua AM, Acero G, Diaz G and
            Gevorkian G.
  TITLE     Increased TSPO expression, pyroglutamate-modified amyloid beta
            (AbetaN3(pE)) accumulation and transient clustering of microglia in
            the thalamus of Tg-SwDI mice
  JOURNAL   J Neuroimmunol 382, 578150 (2023)
   PUBMED   37467699
  REMARK    GeneRIF: Increased TSPO expression, pyroglutamate-modified amyloid
            beta (AbetaN3(pE)) accumulation and transient clustering of
            microglia in the thalamus of Tg-SwDI mice.
REFERENCE   2  (residues 1 to 169)
  AUTHORS   Gallus M, Roll W, Dik A, Barca C, Zinnhardt B, Hicking G, Mueller
            C, Naik VN, Anstotz M, Kramer J, Rolfes L, Wachsmuth L, Pitsch J,
            van Loo KMJ, Rauber S, Okada H, Wimberley C, Strippel C, Golombeck
            KS, Johnen A, Kovac S, Gross CC, Backhaus P, Seifert R, Lewerenz J,
            Surges R, Elger CE, Wiendl H, Ruck T, Becker AJ, Faber C, Jacobs
            AH, Bauer J, Meuth SG, Schafers M and Melzer N.
  TITLE     Translational imaging of TSPO reveals pronounced innate
            inflammation in human and murine CD8 T cell-mediated limbic
            encephalitis
  JOURNAL   Sci Adv 9 (23), eabq7595 (2023)
   PUBMED   37294768
  REMARK    GeneRIF: Translational imaging of TSPO reveals pronounced innate
            inflammation in human and murine CD8 T cell-mediated limbic
            encephalitis.
REFERENCE   3  (residues 1 to 169)
  AUTHORS   Zhang D, Man D, Lu J, Jiang Y, Ding B, Su R, Tong R, Chen J, Yang
            B, Zheng S, Chen D and Wu J.
  TITLE     Mitochondrial TSPO Promotes Hepatocellular Carcinoma Progression
            through Ferroptosis Inhibition and Immune Evasion
  JOURNAL   Adv Sci (Weinh) 10 (15), e2206669 (2023)
   PUBMED   36994647
  REMARK    GeneRIF: Mitochondrial TSPO Promotes Hepatocellular Carcinoma
            Progression through Ferroptosis Inhibition and Immune Evasion.
REFERENCE   4  (residues 1 to 169)
  AUTHORS   Magri A, Lipari CLR, Risiglione P, Zimbone S, Guarino F, Caccamo A
            and Messina A.
  TITLE     ERK1/2-dependent TSPO overactivation associates with the loss of
            mitophagy and mitochondrial respiration in ALS
  JOURNAL   Cell Death Dis 14 (2), 122 (2023)
   PUBMED   36792609
  REMARK    GeneRIF: ERK1/2-dependent TSPO overactivation associates with the
            loss of mitophagy and mitochondrial respiration in ALS.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 169)
  AUTHORS   Liere P, Liu GJ, Pianos A, Middleton RJ, Banati RB and Akwa Y.
  TITLE     The Comprehensive Steroidome in Complete TSPO/PBR Knockout Mice
            under Basal Conditions
  JOURNAL   Int J Mol Sci 24 (3), 2474 (2023)
   PUBMED   36768796
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 169)
  AUTHORS   Letts VA, Valenzuela A, Kirley JP, Sweet HO, Davisson MT and
            Frankel WN.
  TITLE     Genetic and physical maps of the stargazer locus on mouse
            chromosome 15
  JOURNAL   Genomics 43 (1), 62-68 (1997)
   PUBMED   9226373
REFERENCE   7  (residues 1 to 169)
  AUTHORS   Yakovlev AG, Ruffo M, Jurka J and Krueger KE.
  TITLE     Comparison of repetitive elements in the third intron of human and
            rodent mitochondrial benzodiazepine receptor-encoding genes
  JOURNAL   Gene 155 (2), 201-205 (1995)
   PUBMED   7721091
REFERENCE   8  (residues 1 to 169)
  AUTHORS   Taketani S, Kohno H, Okuda M, Furukawa T and Tokunaga R.
  TITLE     Induction of peripheral-type benzodiazepine receptors during
            differentiation of mouse erythroleukemia cells. A possible
            involvement of these receptors in heme biosynthesis
  JOURNAL   J Biol Chem 269 (10), 7527-7531 (1994)
   PUBMED   8125973
REFERENCE   9  (residues 1 to 169)
  AUTHORS   Garnier M, Dimchev AB, Boujrad N, Price JM, Musto NA and
            Papadopoulos V.
  TITLE     In vitro reconstitution of a functional peripheral-type
            benzodiazepine receptor from mouse Leydig tumor cells
  JOURNAL   Mol Pharmacol 45 (2), 201-211 (1994)
   PUBMED   8114671
REFERENCE   10 (residues 1 to 169)
  AUTHORS   Bucan M, Gatalica B, Nolan P, Chung A, Leroux A, Grossman MH,
            Nadeau JH, Emanuel BS and Budarf M.
  TITLE     Comparative mapping of 9 human chromosome 22q loci in the
            laboratory mouse
  JOURNAL   Hum Mol Genet 2 (8), 1245-1252 (1993)
   PUBMED   8401507
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AA472650.1, AK153273.1 and AI841615.1.
            
            On Dec 21, 2007 this sequence version replaced NP_033905.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AA472650.1, BQ938533.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..169
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 39.4 cM"
     Protein         1..169
                     /product="translocator protein"
                     /note="isoquinoline-binding protein; PKBS; mitochondrial
                     benzodiazepine receptor; peripheral-type benzodiazepine
                     receptor; benzodiazepine receptor, peripheral"
                     /calculated_mol_wt=18710
     Site            6..26
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P50637.1)"
     Region          12..156
                     /region_name="TspO_MBR"
                     /note="TspO/MBR family; pfam03073"
                     /db_xref="CDD:427122"
     Site            order(14..15,17..18,20..21,24,68,80,82..84,86..87,89..91,
                     93..94,97..98,117)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:320706"
     Site            order(23,49..50,52..53,95,143,146..147,150)
                     /site_type="lipid-binding"
                     /note="lipid binding site [chemical binding]"
                     /db_xref="CDD:320706"
     Site            47..67
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P50637.1)"
     Site            80..100
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P50637.1)"
     Site            106..126
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P50637.1)"
     Site            135..155
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P50637.1)"
     CDS             1..169
                     /gene="Tspo"
                     /gene_synonym="Bzrp; IBP; PBR; Tspo1"
                     /coded_by="NM_009775.4:102..611"
                     /db_xref="CCDS:CCDS27705.1"
                     /db_xref="GeneID:12257"
                     /db_xref="MGI:MGI:88222"
ORIGIN      
        1 mpeswvpavg ltlvpslggf mgayfvrgeg lrwyaslqkp swhpprwtla piwgtlysam
       61 gygsyivwke lggftedamv plglytgqla lnwawppiff garqmgwala dlllvsgvat
      121 attlawhrvs ppaarllypy lawlafatvl nyyvwrdnsg rrggsrlpe
//
LOCUS       NP_001390659             734 aa            linear   ROD 09-OCT-2023
DEFINITION  transcriptional repressor CTCF isoform 3 [Mus musculus].
ACCESSION   NP_001390659
VERSION     NP_001390659.1
DBSOURCE    REFSEQ: accession NM_001403730.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 734)
  AUTHORS   Hewitt SC, Gruzdev A, Willson CJ, Wu SP, Lydon JP, Galjart N and
            DeMayo FJ.
  TITLE     Chromatin architectural factor CTCF is essential for
            progesterone-dependent uterine maturation
  JOURNAL   FASEB J 37 (8), e23103 (2023)
   PUBMED   37489832
  REMARK    GeneRIF: Chromatin architectural factor CTCF is essential for
            progesterone-dependent uterine maturation.
REFERENCE   2  (residues 1 to 734)
  AUTHORS   Smits WK, Vermeulen C, Hagelaar R, Kimura S, Vroegindeweij EM,
            Buijs-Gladdines JGCAM, van de Geer E, Verstegen MJAM, Splinter E,
            van Reijmersdal SV, Buijs A, Galjart N, van Eyndhoven W, van Min M,
            Kuiper R, Kemmeren P, Mullighan CG, de Laat W and Meijerink JPP.
  TITLE     Elevated enhancer-oncogene contacts and higher oncogene expression
            levels by recurrent CTCF inactivating mutations in acute T cell
            leukemia
  JOURNAL   Cell Rep 42 (4), 112373 (2023)
   PUBMED   37060567
REFERENCE   3  (residues 1 to 734)
  AUTHORS   Wang B, Ji L and Bian Q.
  TITLE     SATB1 regulates 3D genome architecture in T cells by constraining
            chromatin interactions surrounding CTCF-binding sites
  JOURNAL   Cell Rep 42 (4), 112323 (2023)
   PUBMED   37000624
  REMARK    GeneRIF: SATB1 regulates 3D genome architecture in T cells by
            constraining chromatin interactions surrounding CTCF-binding sites.
REFERENCE   4  (residues 1 to 734)
  AUTHORS   Marina-Zarate E, Rodriguez-Ronchel A, Gomez MJ, Sanchez-Cabo F and
            Ramiro AR.
  TITLE     Low-affinity CTCF binding drives transcriptional regulation whereas
            high-affinity binding encompasses architectural functions
  JOURNAL   iScience 26 (3), 106106 (2023)
   PUBMED   36852270
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 734)
  AUTHORS   Hsieh TS, Cattoglio C, Slobodyanyuk E, Hansen AS, Darzacq X and
            Tjian R.
  TITLE     Enhancer-promoter interactions and transcription are largely
            maintained upon acute loss of CTCF, cohesin, WAPL or YY1
  JOURNAL   Nat Genet 54 (12), 1919-1932 (2022)
   PUBMED   36471071
  REMARK    GeneRIF: Enhancer-promoter interactions and transcription are
            largely maintained upon acute loss of CTCF, cohesin, WAPL or YY1.
REFERENCE   6  (residues 1 to 734)
  AUTHORS   Farrell CM, West AG and Felsenfeld G.
  TITLE     Conserved CTCF insulator elements flank the mouse and human
            beta-globin loci
  JOURNAL   Mol Cell Biol 22 (11), 3820-3831 (2002)
   PUBMED   11997516
  REMARK    GeneRIF: Conserved CTCF insulator elements flank the mouse and
            human beta-globin loci.
REFERENCE   7  (residues 1 to 734)
  AUTHORS   Burke LJ, Hollemann T, Pieler T and Renkawitz R.
  TITLE     Molecular cloning and expression of the chromatin insulator protein
            CTCF in Xenopus laevis
  JOURNAL   Mech Dev 113 (1), 95-98 (2002)
   PUBMED   11900981
REFERENCE   8  (residues 1 to 734)
  AUTHORS   Chao W, Huynh KD, Spencer RJ, Davidow LS and Lee JT.
  TITLE     CTCF, a candidate trans-acting factor for X-inactivation choice
  JOURNAL   Science 295 (5553), 345-347 (2002)
   PUBMED   11743158
  REMARK    GeneRIF: It's proposed that Tsix and CTCF together establish a
            regulatable epigenetic switch for X-inactivation.
REFERENCE   9  (residues 1 to 734)
  AUTHORS   Lutz M, Burke LJ, Barreto G, Goeman F, Greb H, Arnold R,
            Schultheiss H, Brehm A, Kouzarides T, Lobanenkov V and Renkawitz R.
  TITLE     Transcriptional repression by the insulator protein CTCF involves
            histone deacetylases
  JOURNAL   Nucleic Acids Res 28 (8), 1707-1713 (2000)
   PUBMED   10734189
REFERENCE   10 (residues 1 to 734)
  AUTHORS   Filippova GN, Fagerlie S, Klenova EM, Myers C, Dehner Y, Goodwin G,
            Neiman PE, Collins SJ and Lobanenkov VV.
  TITLE     An exceptionally conserved transcriptional repressor, CTCF, employs
            different combinations of zinc fingers to bind diverged promoter
            sequences of avian and mammalian c-myc oncogenes
  JOURNAL   Mol Cell Biol 16 (6), 2802-2813 (1996)
   PUBMED   8649389
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127419.3 and AC152826.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14995044.296149.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..734
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.04 cM"
     Protein         1..734
                     /product="transcriptional repressor CTCF isoform 3"
                     /note="transcriptional repressor CTCF; CTCFL paralog;
                     11-zinc finger protein"
                     /calculated_mol_wt=83443
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          180..211
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61164.2)"
     Region          266..289
                     /region_name="zf-H2C2_5"
                     /note="C2H2-type zinc-finger domain; pfam13909"
                     /db_xref="CDD:404746"
     Region          268..288
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(273,275,277,279..280,283..284,287,301,303,307..308,
                     311..312,315,329,331,333,335..336,339..340,346)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          280..305
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:433230"
     Site            289
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          296..316
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          309..333
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:433230"
     Site            317
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          324..347
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          351..375
                     /region_name="zf-H2C2_5"
                     /note="C2H2-type zinc-finger domain; pfam13909"
                     /db_xref="CDD:404746"
     Region          353..373
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          <366..500
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Site            374
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          381..401
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            402
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          409..426
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          439..457
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          469..489
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(474,476,478,480..481,484..485,488,502,504,508..509,
                     512..513,516,530,532,534,536..537,540..541,545)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          497..517
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          509..534
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:433230"
     Region          525..546
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          557..573
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            609
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Site            610
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Site            612
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          697..724
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61164.2)"
     CDS             1..734
                     /gene="Ctcf"
                     /coded_by="NM_001403730.1:743..2947"
                     /note="isoform 3 is encoded by transcript variant 10"
                     /db_xref="GeneID:13018"
                     /db_xref="MGI:MGI:109447"
ORIGIN      
        1 megeaveaiv eesetfikgk erktyqrrre ggqeedachl pqnqtdggev vqdvnssvqm
       61 vmmeqldptl lqmktevmeg tvapeaeaav ddtqiitlqv vnmeeqpini gelqlvqvpv
      121 pvtvpvatts veelqgayen evskeglaes epmichtlpl pegfqvvkvg angevetleq
      181 gelppqedss wqkdpdyqpp akktkktkks klryteegkd vdvsvydfee eqqegllsev
      241 naekvvgnmk ppkptkikkk gvkktfqcel csytcprrsn ldrhmkshtd erphkchlcg
      301 rafrtvtllr nhlnthtgtr phkcpdcdma fvtsgelvrh rrykhthekp fkcsmcdyas
      361 vevsklkrhi rshtgerpfq cslcsyasrd tyklkrhmrt hsgekpyecy icharftqsg
      421 tmkmhilqkh tenvakfhcp hcdtviarks dlgvhlrkqh syieqgkkcr ycdavfhery
      481 aliqhqkshk nekrfkcdqc dyacrqerhm imhkrthtge kpyacshcdk tfrqkqlldm
      541 hfkryhdpnf vpaafvcskc gktftrrntm arhadncagp dgvegengge tkkskrgrkr
      601 kmrskkedss dseenaepdl ddneeeeepa veiepepepq pqpppppqpv apapppakkr
      661 rgrppgrtnq pkqnqpiiqv edqntgaien iivevkkepd aepaegeeee aqaattdapn
      721 gdltpemils mmdr
//
LOCUS       NP_034860                346 aa            linear   ROD 09-OCT-2023
DEFINITION  annexin A1 [Mus musculus].
ACCESSION   NP_034860
VERSION     NP_034860.2
DBSOURCE    REFSEQ: accession NM_010730.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 346)
  AUTHORS   Xiao D, Zeng T, Zhu W, Yu ZZ, Huang W, Yi H, Lu SS, Feng J, Feng
            XP, Wu D, Wen Q, Zhou JH, Yuan L, Zhuang W and Xiao ZQ.
  TITLE     ANXA1 Promotes Tumor Immune Evasion by Binding PARP1 and
            Upregulating Stat3-Induced Expression of PD-L1 in Multiple Cancers
  JOURNAL   Cancer Immunol Res 11 (10), 1367-1383 (2023)
   PUBMED   37566399
  REMARK    GeneRIF: ANXA1 Promotes Tumor Immune Evasion by Binding PARP1 and
            Upregulating Stat3-Induced Expression of PD-L1 in Multiple Cancers.
REFERENCE   2  (residues 1 to 346)
  AUTHORS   Zhang J, Wang H, Liu J, Fu L and Peng S.
  TITLE     ANXA1 is identified as a key gene associated with high risk and T
            cell infiltration in primary sclerosing cholangitis
  JOURNAL   Hum Genomics 17 (1), 86 (2023)
   PUBMED   37735492
  REMARK    GeneRIF: ANXA1 is identified as a key gene associated with high
            risk and T cell infiltration in primary sclerosing cholangitis.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 346)
  AUTHORS   Abd El-Salam M, El-Tanbouly G, Bastos J and Metwaly H.
  TITLE     Suppression of VEGF and inflammatory cytokines, modulation of
            Annexin A1 and organ functions by galloylquinic acids in breast
            cancer model
  JOURNAL   Sci Rep 13 (1), 12268 (2023)
   PUBMED   37507468
  REMARK    GeneRIF: Suppression of VEGF and inflammatory cytokines, modulation
            of Annexin A1 and organ functions by galloylquinic acids in breast
            cancer model.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 346)
  AUTHORS   Irie M, Kabata H, Sasahara K, Kurihara M, Shirasaki Y, Kamatani T,
            Baba R, Matsusaka M, Koga S, Masaki K, Miyata J, Araki Y, Kikawada
            T, Kabe Y, Suematsu M, Yamagishi M, Uemura S, Moro K and Fukunaga
            K.
  TITLE     Annexin A1 is a cell-intrinsic metalloregulator of zinc in human
            ILC2s
  JOURNAL   Cell Rep 42 (6), 112610 (2023)
   PUBMED   37294636
REFERENCE   5  (residues 1 to 346)
  AUTHORS   Moreli JB, Santos MRD, Calderon IMP, Hebeda CB, Farsky SHP,
            Bevilacqua E and Oliani SM.
  TITLE     The Role of Annexin A1 in DNA Damage Response in Placental Cells:
            Impact on Gestational Diabetes Mellitus
  JOURNAL   Int J Mol Sci 24 (12), 10155 (2023)
   PUBMED   37373303
  REMARK    GeneRIF: The Role of Annexin A1 in DNA Damage Response in Placental
            Cells: Impact on Gestational Diabetes Mellitus.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 346)
  AUTHORS   Epifano O, Liang LF and Dean J.
  TITLE     Mouse Zp1 encodes a zona pellucida protein homologous to egg
            envelope proteins in mammals and fish
  JOURNAL   J Biol Chem 270 (45), 27254-27258 (1995)
   PUBMED   7592984
REFERENCE   7  (residues 1 to 346)
  AUTHORS   Wen XY, Tang S and Breitman ML.
  TITLE     Genetic mapping of two mouse homeobox genes Tlx-1 and Tlx-2 to
            murine chromosomes 19 and 6
  JOURNAL   Genomics 24 (2), 388-390 (1994)
   PUBMED   7698766
REFERENCE   8  (residues 1 to 346)
  AUTHORS   Horlick KR, Cheng IC, Wong WT, Wakeland EK and Nick HS.
  TITLE     Mouse lipocortin I gene structure and chromosomal assignment: gene
            duplication and the origins of a gene family
  JOURNAL   Genomics 10 (2), 365-374 (1991)
   PUBMED   1676980
REFERENCE   9  (residues 1 to 346)
  AUTHORS   Philipps C, Rose-John S, Rincke G, Furstenberger G and Marks F.
  TITLE     cDNA-cloning, sequencing and expression in
            glucocorticoid-stimulated quiescent Swiss 3T3 fibroblasts of mouse
            lipocortin I
  JOURNAL   Biochem Biophys Res Commun 159 (1), 155-162 (1989)
   PUBMED   2522299
REFERENCE   10 (residues 1 to 346)
  AUTHORS   Sakata T, Iwagami S, Tsuruta Y, Suzuki R, Hojo K, Sato K and
            Teraoka H.
  TITLE     Mouse lipocortin I cDNA
  JOURNAL   Nucleic Acids Res 16 (24), 11818 (1988)
   PUBMED   2974946
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK167612.1.
            
            On Feb 7, 2007 this sequence version replaced NP_034860.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK150564.1, AK150718.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..346
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 13.83 cM"
     Protein         1..346
                     /product="annexin A1"
                     /note="p35; annexin I; annexin-1; calpactin II; lipocortin
                     I; chromobindin-9; phospholipase A2 inhibitory protein;
                     calpactin-2; lipocortin 1"
                     /calculated_mol_wt=38603
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:P04083; propagated from
                     UniProtKB/Swiss-Prot (P10107.2)"
     Site            5
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by TRPM7.
                     /evidence=ECO:0000250|UniProtKB:P04083; propagated from
                     UniProtKB/Swiss-Prot (P10107.2)"
     Site            21
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0007744|PubMed:19131326; propagated from
                     UniProtKB/Swiss-Prot (P10107.2)"
     Site            26..27
                     /site_type="cleavage"
                     /note="Cleavage, by CTSG.
                     /evidence=ECO:0000250|UniProtKB:P04083; propagated from
                     UniProtKB/Swiss-Prot (P10107.2)"
     Site            27
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKC.
                     /evidence=ECO:0000250|UniProtKB:P04083; propagated from
                     UniProtKB/Swiss-Prot (P10107.2)"
     Site            34
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P04083; propagated from
                     UniProtKB/Swiss-Prot (P10107.2)"
     Site            37
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P04083; propagated from
                     UniProtKB/Swiss-Prot (P10107.2)"
     Region          42..113
                     /region_name="Annexin 1.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01245"
                     /note="propagated from UniProtKB/Swiss-Prot (P10107.2)"
     Region          47..111
                     /region_name="Annexin"
                     /note="pfam00191"
                     /db_xref="CDD:395139"
     Site            58
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P10107.2)"
     Region          114..185
                     /region_name="Annexin 2.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01245"
                     /note="propagated from UniProtKB/Swiss-Prot (P10107.2)"
     Region          118..183
                     /region_name="Annexin"
                     /note="pfam00191"
                     /db_xref="CDD:395139"
     Site            136
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P04083; propagated from
                     UniProtKB/Swiss-Prot (P10107.2)"
     Region          197..269
                     /region_name="Annexin 3.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01245"
                     /note="propagated from UniProtKB/Swiss-Prot (P10107.2)"
     Region          202..267
                     /region_name="Annexin"
                     /note="pfam00191"
                     /db_xref="CDD:395139"
     Region          273..344
                     /region_name="Annexin 4.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01245"
                     /note="propagated from UniProtKB/Swiss-Prot (P10107.2)"
     Region          277..342
                     /region_name="Annexin"
                     /note="pfam00191"
                     /db_xref="CDD:395139"
     Site            312
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P10107.2)"
     CDS             1..346
                     /gene="Anxa1"
                     /gene_synonym="Anx-1; Anx-A1; C430014K04Rik; Lpc-1; Lpc1"
                     /coded_by="NM_010730.2:75..1115"
                     /db_xref="CCDS:CCDS29692.1"
                     /db_xref="GeneID:16952"
                     /db_xref="MGI:MGI:96819"
ORIGIN      
        1 mamvseflkq arflenqeqe yvqavksykg gpgsavspyp sfnvssdvaa lhkaimvkgv
       61 deatiidilt krtnaqrqqi kaaylqengk pldevlrkal tghleevvla mlktpaqfda
      121 delrgamkgl gtdedtliei lttrsneqir einrvyreel krdlakdits dtsgdfrkal
      181 lalakgdrcq dlsvnqdlad tdaralyeag errkgtdvnv fttiltsrsf phlrrvfqny
      241 gkysqhdmnk aldlelkgdi ekclttivkc atstpaffae klyeamkgag trhkalirim
      301 vsrseidmne ikvfyqkkyg islcqailde tkgdyekilv alcggn
//
LOCUS       NP_001300956             688 aa            linear   ROD 09-OCT-2023
DEFINITION  aryl hydrocarbon receptor isoform 2 [Mus musculus].
ACCESSION   NP_001300956
VERSION     NP_001300956.1
DBSOURCE    REFSEQ: accession NM_001314027.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 688)
  AUTHORS   Major J, Crotta S, Finsterbusch K, Chakravarty P, Shah K, Frederico
            B, D'Antuono R, Green M, Meader L, Suarez-Bonnet A, Priestnall S,
            Stockinger B and Wack A.
  TITLE     Endothelial AHR activity prevents lung barrier disruption in viral
            infection
  JOURNAL   Nature 621 (7980), 813-820 (2023)
   PUBMED   37587341
  REMARK    GeneRIF: Endothelial AHR activity prevents lung barrier disruption
            in viral infection.
REFERENCE   2  (residues 1 to 688)
  AUTHORS   Sheu ML, Pan LY, Yang CN, Sheehan J, Pan LY, You WC, Wang CC and
            Pan HC.
  TITLE     Thrombin-Induced Microglia Activation Modulated through Aryl
            Hydrocarbon Receptors
  JOURNAL   Int J Mol Sci 24 (14), 11416 (2023)
   PUBMED   37511175
  REMARK    GeneRIF: Thrombin-Induced Microglia Activation Modulated through
            Aryl Hydrocarbon Receptors.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 688)
  AUTHORS   Balestrieri N, Palzkill V, Pass C, Tan J, Salyers ZR, Moparthy C,
            Murillo A, Kim K, Thome T, Yang Q, O'Malley KA, Berceli SA, Yue F,
            Scali ST, Ferreira LF and Ryan TE.
  TITLE     Activation of the Aryl Hydrocarbon Receptor in Muscle Exacerbates
            Ischemic Pathology in Chronic Kidney Disease
  JOURNAL   Circ Res 133 (2), 158-176 (2023)
   PUBMED   37325935
  REMARK    GeneRIF: Activation of the Aryl Hydrocarbon Receptor in Muscle
            Exacerbates Ischemic Pathology in Chronic Kidney Disease.
REFERENCE   4  (residues 1 to 688)
  AUTHORS   Liu J, Zhang X, Zhang Y, Qian M, Yang M, Yang S and Wang L.
  TITLE     Farnesyl diphosphate synthase exacerbates nonalcoholic
            steatohepatitis via the activation of AHR-CD36 axis
  JOURNAL   FASEB J 37 (7), e23035 (2023)
   PUBMED   37310396
  REMARK    GeneRIF: Farnesyl diphosphate synthase exacerbates nonalcoholic
            steatohepatitis via the activation of AHR-CD36 axis.
REFERENCE   5  (residues 1 to 688)
  AUTHORS   Haque N, Ojo ES, Krager SL and Tischkau SA.
  TITLE     Deficiency of Adipose Aryl Hydrocarbon Receptor Protects against
            Diet-Induced Metabolic Dysfunction through Sexually Dimorphic
            Mechanisms
  JOURNAL   Cells 12 (13), 1748 (2023)
   PUBMED   37443781
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 688)
  AUTHORS   Okey,A.B., Bondy,G.P., Mason,M.E., Kahl,G.F., Eisen,H.J.,
            Guenthner,T.M. and Nebert,D.W.
  TITLE     Regulatory gene product of the Ah locus. Characterization of the
            cytosolic inducer-receptor complex and evidence for its nuclear
            translocation
  JOURNAL   J Biol Chem 254 (22), 11636-11648 (1979)
   PUBMED   500663
REFERENCE   7  (residues 1 to 688)
  AUTHORS   Levitt,R.C., Fysh,J.M., Jensen,N.M. and Nebert,D.W.
  TITLE     The Ah locus: biochemical basis for genetic differences in brain
            tumor formation in mice
  JOURNAL   Genetics 92 (4), 1205-1210 (1979)
   PUBMED   520822
REFERENCE   8  (residues 1 to 688)
  AUTHORS   Wood,A.W. and Taylor,B.A.
  TITLE     Genetic regulation of coumarin hydroxylase activity in mice.
            Evidence for single locus control on chromosome
  JOURNAL   J Biol Chem 254 (13), 5647-5651 (1979)
   PUBMED   447675
REFERENCE   9  (residues 1 to 688)
  AUTHORS   Kouri,R.E., Rude,T.H., Joglekar,R., Dansette,P.M., Jerina,D.M.,
            Atlas,S.A., Owens,I.S. and Nebert,D.W.
  TITLE     2,3,7,8-tetrachlorodibenzo-p-dioxin as cocarcinogen causing
            3-methylcholanthrene-initiated subcutaneous tumors in mice
            genetically 'nonresponsive' at Ah locus
  JOURNAL   Cancer Res 38 (9), 2777-2783 (1978)
   PUBMED   679184
REFERENCE   10 (residues 1 to 688)
  AUTHORS   Thorgeirsson,S.S. and Nebert,D.W.
  TITLE     The Ah locus and the metabolism of chemical carcinogens and other
            foreign compounds
  JOURNAL   Adv Cancer Res 25, 149-193 (1977)
   PUBMED   405846
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK153678.1 and AY662081.1.
            
            Summary: The protein encoded by this gene is a ligand-activated
            helix-loop-helix transcription factor involved in the regulation of
            biological responses to planar aromatic hydrocarbons. This receptor
            has been shown to regulate xenobiotic-metabolizing enzymes such as
            cytochrome P450. Before ligand binding, the encoded protein is
            sequestered in the cytoplasm; upon ligand binding, this protein
            moves to the nucleus and stimulates transcription of target genes.
            Two transcript variants encoding different isoforms have been found
            for this gene. [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (2) lacks an alternate coding exon
            compared to variant 1. The resulting isoform (2) has a shorter and
            distinct N-terminus compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..688
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 15.78 cM"
     Protein         1..688
                     /product="aryl hydrocarbon receptor isoform 2"
                     /note="ah receptor; dioxin receptor"
                     /calculated_mol_wt=76921
     Region          3..>60
                     /region_name="PAS"
                     /note="PAS domain; PAS motifs appear in archaea,
                     eubacteria and eukarya. Probably the most surprising
                     identification of a PAS domain was that in EAG-like
                     K+-channels. PAS domains have been found to bind ligands,
                     and to act as sensors for light and oxygen in...; cd00130"
                     /db_xref="CDD:238075"
     Region          174..259
                     /region_name="PAS_3"
                     /note="PAS fold; pfam08447"
                     /db_xref="CDD:430001"
     Site            order(177,181,187,201..204,230,235)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:238075"
     Site            order(198,202,210,213..214,242,244)
                     /site_type="other"
                     /note="heme pocket [chemical binding]"
                     /db_xref="CDD:238075"
     CDS             1..688
                     /gene="Ahr"
                     /gene_synonym="Ah; Ahh; Ahre; bHLHe76; In"
                     /coded_by="NM_001314027.1:614..2680"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="GeneID:11622"
                     /db_xref="MGI:MGI:105043"
ORIGIN      
        1 malngfvlvv tadalvfyas stiqdylgfq qsdvihqsvy elihtedrae fqrqlhwaln
       61 pdsaqgvdea hgppqaavyy tpdqlppena sfmercfrcr lrclldnssg flamnfqgrl
      121 kylhgqnkkg kdgallppql alfaiatplq ppsileirtk nfifrtkhkl dftpigcdak
      181 gqlilgytev elctrgsgyq fihaadilhc aeshirmikt gesgmtvfrl lakhsrwrwv
      241 qsnarliyrn grpdyiiatq rpltdeegre hlqkrstslp fmfatgeavl yeisspfspi
      301 mdplpirtks ntsrkdwapq stpskdsfhp sslmsaliqq desiylcpps spalldshfl
      361 mgsvskcgsw qdsfaaagse aalkheqigh aqdvnlalsg gpselfpdnk nndlysimrn
      421 lgidfedirs mqneeffrtd staagevdfk diditdeilt yvqdslnnst llnsacqqqp
      481 vtqhlscmlq erlqleqqqq lqqpppqale pqqqlcqmvc pqqdlgpkht qingtfaswn
      541 ptppvsfncp qqelkhyqlf sslqgtaqef pykpevdsvp ytqnfapcnq pllpehsksv
      601 qldfpgrdfe pslhpttsnl dfvsclqvpe nqshginsqs amvspqayya gamsmyqcqp
      661 gpqrtpvdqt qysseipgsq aflskvqs
//
LOCUS       NP_033857               1149 aa            linear   ROD 09-OCT-2023
DEFINITION  phospholipid-transporting ATPase IA isoform b [Mus musculus].
ACCESSION   NP_033857
VERSION     NP_033857.1
DBSOURCE    REFSEQ: accession NM_009727.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1149)
  AUTHORS   Xu H, Oses-Prieto JA, Khvotchev M, Jain S, Liang J, Burlingame A
            and Edwards RH.
  TITLE     Adaptor protein AP-3 produces synaptic vesicles that release at
            high frequency by recruiting phospholipid flippase ATP8A1
  JOURNAL   Nat Neurosci 26 (10), 1685-1700 (2023)
   PUBMED   37723322
  REMARK    GeneRIF: Adaptor protein AP-3 produces synaptic vesicles that
            release at high frequency by recruiting phospholipid flippase
            ATP8A1.
REFERENCE   2  (residues 1 to 1149)
  AUTHORS   Zheng L, Pan C, Tian W, Liang C, Feng Y, He W, Yang Z, Wang B, Qiu
            Q, Li N, Sun Y, Qiu H, Sample KM, Zhou L, Zhu X and Hu Y.
  TITLE     Atp8a1 deletion increases the proliferative activity of
            hematopoietic stem cells by impairing PTEN function
  JOURNAL   Cell Oncol (Dordr) 46 (4), 1069-1083 (2023)
   PUBMED   36930333
  REMARK    GeneRIF: Atp8a1 deletion increases the proliferative activity of
            hematopoietic stem cells by impairing PTEN function.
REFERENCE   3  (residues 1 to 1149)
  AUTHORS   Kook S, Wang P, Meng S, Jetter CS, Sucre JMS, Benjamin JT, Gokey
            JJ, Hanby HA, Jaume A, Goetzl L, Marks MS and Guttentag SH.
  TITLE     AP-3-dependent targeting of flippase ATP8A1 to lamellar bodies
            suppresses activation of YAP in alveolar epithelial type 2 cells
  JOURNAL   Proc Natl Acad Sci U S A 118 (20) (2021)
   PUBMED   33990468
REFERENCE   4  (residues 1 to 1149)
  AUTHORS   Yap YT, Li YH, Li W, Banerjee P and Zhang Z.
  TITLE     ATP8a1, an IFT27 binding partner, is dispensable for
            spermatogenesis and male fertility
  JOURNAL   Mol Reprod Dev 88 (5), 371-375 (2021)
   PUBMED   33821543
  REMARK    GeneRIF: ATP8a1, an IFT27 binding partner, is dispensable for
            spermatogenesis and male fertility.
REFERENCE   5  (residues 1 to 1149)
  AUTHORS   Jing W, Yabas M, Broer A, Coupland L, Gardiner EE, Enders A and
            Broer S.
  TITLE     Calpain cleaves phospholipid flippase ATP8A1 during apoptosis in
            platelets
  JOURNAL   Blood Adv 3 (3), 219-229 (2019)
   PUBMED   30674456
  REMARK    GeneRIF: ATP8A1 is cleaved by the cysteine protease calpain during
            apoptosis, and the cleavage is prevented indirectly by caspase
            inhibition, involving blockage of calcium influx into platelets and
            subsequent calpain activation.
REFERENCE   6  (residues 1 to 1149)
  AUTHORS   Wang L, Beserra C and Garbers DL.
  TITLE     A novel aminophospholipid transporter exclusively expressed in
            spermatozoa is required for membrane lipid asymmetry and normal
            fertilization
  JOURNAL   Dev Biol 267 (1), 203-215 (2004)
   PUBMED   14975727
  REMARK    GeneRIF: role in normal phospholipid distribution in the bilayer,
            and for normal binding, penetration, and signaling by the zona
            pellucida
REFERENCE   7  (residues 1 to 1149)
  AUTHORS   Ding J, Wu Z, Crider BP, Ma Y, Li X, Slaughter C, Gong L and Xie
            XS.
  TITLE     Identification and functional expression of four isoforms of ATPase
            II, the putative aminophospholipid translocase. Effect of isoform
            variation on the ATPase activity and phospholipid specificity
  JOURNAL   J Biol Chem 275 (30), 23378-23386 (2000)
   PUBMED   10801890
REFERENCE   8  (residues 1 to 1149)
  AUTHORS   Wang Y, Saigoh K, Osaka H, Yamanishi T, Suh J, Kiyosawa H, Sakai Y,
            Wakana S and Wada K.
  TITLE     YAC/BAC-based physical and transcript mapping around the gracile
            axonal dystrophy (gad) locus identifies Uchl1, Pmx2b, Atp3a2, and
            Hip2 genes
  JOURNAL   Genomics 66 (3), 333-336 (2000)
   PUBMED   10873389
REFERENCE   9  (residues 1 to 1149)
  AUTHORS   Halleck MS, Lawler JF JR, Blackshaw S, Gao L, Nagarajan P, Hacker
            C, Pyle S, Newman JT, Nakanishi Y, Ando H, Weinstock D, Williamson
            P and Schlegel RA.
  TITLE     Differential expression of putative transbilayer amphipath
            transporters
  JOURNAL   Physiol Genomics 1 (3), 139-150 (1999)
   PUBMED   11015572
  REMARK    Publication Status: Online-Only
REFERENCE   10 (residues 1 to 1149)
  AUTHORS   Halleck MS, Pradhan D, Blackman C, Berkes C, Williamson P and
            Schlegel RA.
  TITLE     Multiple members of a third subfamily of P-type ATPases identified
            by genomic sequences and ESTs
  JOURNAL   Genome Res 8 (4), 354-361 (1998)
   PUBMED   9548971
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK151709.1, AK045367.1, AK141559.1, AK039919.1, BC094235.1 and
            AC123662.13.
            
            Transcript Variant: This variant (2) contains an alternate exon and
            lacks two other alternate exons in the 5' coding region, compared
            to variant 1. It encodes isoform b, which is shorter than isoform
            a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK076388.1, U75321.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1149
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 36.15 cM"
     Protein         1..1149
                     /product="phospholipid-transporting ATPase IA isoform b"
                     /EC_number="7.6.2.1"
                     /note="probable phospholipid-transporting ATPase IA;
                     chromaffin granule ATPase II; ATPase class I type 8A
                     member 1; ATPase 8A1, p type; ATPase 8A1,
                     aminophospholipid transporter (APLT), class I; P4-ATPase
                     flippase complex alpha subunit ATP8A1; ATPase,
                     aminophospholipid transporter (APLT), class I, type 8A,
                     member 1"
                     /calculated_mol_wt=129636
     Region          49..1071
                     /region_name="ATPase-Plipid"
                     /note="phospholipid-translocating P-type ATPase, flippase;
                     TIGR01652"
                     /db_xref="CDD:273734"
     CDS             1..1149
                     /gene="Atp8a1"
                     /gene_synonym="APLT; Atp3a2; B230107D19Rik; ClassI"
                     /coded_by="NM_009727.3:222..3671"
                     /note="isoform b is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS39105.1"
                     /db_xref="GeneID:11980"
                     /db_xref="MGI:MGI:1330848"
ORIGIN      
        1 mptmrrtvse irsraegyek tddvsektsl adqeevrtif inqpqltkfc nnhvstakyn
       61 vitflprfly sqfrraansf flfiallqqi pdvsptgryt tlvpllfila vaaikeiied
      121 ikrhkadnav nkkqtqvlrn gaweivhwek vnvgdiviik gkeyipadtv llsssepqam
      181 cyietsnldg etnlkirqgl patsdikdid slmrisgrie cespnrhlyd fvgnirldgh
      241 gtvplgadqi llrgaqlrnt qwvhgivvyt ghdtklmqns tspplklsnv eritnvqili
      301 lfciliamsl vcsvgsaiwn rrhsgkdwyl hlhyggasnf glnfltfiil fnnlipisll
      361 vtlevvkftq ayfinwdldm hyeptdtaam artsnlneel gqvkyifsdk tgtltcnvmq
      421 fkkctiagva ygqssqfgde ktfndpslld nlqnnhptap iicefltmma vchtavpere
      481 gdkiiyqaas pdegalvraa kqlnfvftgr tpdsviidsl gqeeryelln vleftsarkr
      541 msvvvrtpsg klrlyckgad tviyerlaet skykeitlkh leqfateglr tlcfavaeis
      601 esdfeewrav yhrastsvqn rllkleesye lieknlqllg ataiedklqd qvpetietlm
      661 kadikiwilt gdkqetaini ghscrllkrn mgmivinegs ldgtretlsr hcttlgdalr
      721 kendfaliid gktlkyaltf gvrqyfldla lsckaviccr vsplqksevv emvkkqvkvi
      781 tlaigdgand vsmiqtahvg vgisgneglq aanssdysia qfkylknllm vhgawnynrv
      841 skcilycfyk nivlyiieiw fafvngfsgq ilferwcigl ynvmftampp ltlgifersc
      901 rkenmlkype lyktsqnald fntkvfwvhc lnglfhsvil fwfplkalqy gtvfgngkts
      961 dylllgnfvy tfvvitvclk agletsywtw fshiaiwgsi alwvvffgiy sslwpavpma
     1021 pdmsgeaaml fssgvfwvgl lsipvaslll dvlykvikrt afktlvdevq eleaksqdpg
     1081 avvlgkslte raqllknvfk knhvnlyrse slqqnllhgy afsqdengiv sqsevirayd
     1141 ttkqrpdew
//
LOCUS       NP_001394508             426 aa            linear   ROD 09-OCT-2023
DEFINITION  mitogen-activated protein kinase 10 isoform 3 [Mus musculus].
ACCESSION   NP_001394508
VERSION     NP_001394508.1
DBSOURCE    REFSEQ: accession NM_001407579.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 426)
  AUTHORS   Priego M, Noriega L, Kalinin S, Hoffman LM, Feinstein DL and
            Morfini G.
  TITLE     Genetic deletion of c-Jun amino-terminal kinase 3 (JNK3) modestly
            increases disease severity in a mouse model of multiple sclerosis
  JOURNAL   J Neuroimmunol 382, 578152 (2023)
   PUBMED   37454525
  REMARK    GeneRIF: Genetic deletion of c-Jun amino-terminal kinase 3 (JNK3)
            modestly increases disease severity in a mouse model of multiple
            sclerosis.
REFERENCE   2  (residues 1 to 426)
  AUTHORS   Liu F, Deng Y, Zhao Y, Li Z, Gao J, Zhang Y, Yang X, Liu Y and Xia
            Y.
  TITLE     Time series RNA-seq analysis identifies MAPK10 as a critical gene
            in diabetes mellitus-induced atrial fibrillation in mice
  JOURNAL   J Mol Cell Cardiol 168, 70-82 (2022)
   PUBMED   35489387
  REMARK    GeneRIF: Time series RNA-seq analysis identifies MAPK10 as a
            critical gene in diabetes mellitus-induced atrial fibrillation in
            mice.
REFERENCE   3  (residues 1 to 426)
  AUTHORS   Cunningham JG, Scripter JD, Nti SA and Tucker ES.
  TITLE     Early construction of the thalamocortical axon pathway requires
            c-Jun N-terminal kinase signaling within the ventral forebrain
  JOURNAL   Dev Dyn 251 (3), 459-480 (2022)
   PUBMED   34494344
REFERENCE   4  (residues 1 to 426)
  AUTHORS   Goodwani S, Fernandez C, Acton PJ, Buggia-Prevot V, McReynolds ML,
            Ma J, Hu CH, Hamby ME, Jiang Y, Le K, Soth MJ, Jones P and Ray WJ.
  TITLE     Dual Leucine Zipper Kinase Is Constitutively Active in the Adult
            Mouse Brain and Has Both Stress-Induced and Homeostatic Functions
  JOURNAL   Int J Mol Sci 21 (14), 4849 (2020)
   PUBMED   32659913
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 426)
  AUTHORS   Loughran G, Chou MY, Ivanov IP, Jungreis I, Kellis M, Kiran AM,
            Baranov PV and Atkins JF.
  TITLE     Evidence of efficient stop codon readthrough in four mammalian
            genes
  JOURNAL   Nucleic Acids Res 42 (14), 8928-8938 (2014)
   PUBMED   25013167
REFERENCE   6  (residues 1 to 426)
  AUTHORS   Beier H and Grimm M.
  TITLE     Misreading of termination codons in eukaryotes by natural nonsense
            suppressor tRNAs
  JOURNAL   Nucleic Acids Res 29 (23), 4767-4782 (2001)
   PUBMED   11726686
  REMARK    Review article
REFERENCE   7  (residues 1 to 426)
  AUTHORS   Yang DD, Kuan CY, Whitmarsh AJ, Rincon M, Zheng TS, Davis RJ, Rakic
            P and Flavell RA.
  TITLE     Absence of excitotoxicity-induced apoptosis in the hippocampus of
            mice lacking the Jnk3 gene
  JOURNAL   Nature 389 (6653), 865-870 (1997)
   PUBMED   9349820
REFERENCE   8  (residues 1 to 426)
  AUTHORS   Casanova E, Garate C, Ovalle S, Calvo P and Chinchetru MA.
  TITLE     Identification of four splice variants of the mouse
            stress-activated protein kinase JNK/SAPK alpha-isoform
  JOURNAL   Neuroreport 7 (7), 1320-1324 (1996)
   PUBMED   8817558
REFERENCE   9  (residues 1 to 426)
  AUTHORS   Martin JH, Mohit AA and Miller CA.
  TITLE     Developmental expression in the mouse nervous system of the p493F12
            SAP kinase
  JOURNAL   Brain Res Mol Brain Res 35 (1-2), 47-57 (1996)
   PUBMED   8717339
REFERENCE   10 (residues 1 to 426)
  AUTHORS   Suzuki J, Yoshida S, Chen ZL, Momota Y, Kato K, Hirata A and
            Shiosaka S.
  TITLE     Ontogeny of neuropsin mRNA expression in the mouse brain
  JOURNAL   Neurosci Res 23 (4), 345-351 (1995)
   PUBMED   8602273
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC160244.11, AC123664.15,
            AC137121.9 and AC125252.7.
            
            Summary: The protein encoded by this gene is a member of the MAP
            kinase family. MAP kinases act as integration points for multiple
            biochemical signals, and thus are involved in a wide variety of
            cellular processes, such as proliferation, differentiation,
            transcription regulation and development. This kinase is
            specifically expressed in a subset of neurons in the nervous system
            and is activated by threonine and tyrosine phosphorylation.
            Targeted deletion of this gene in mice suggests that it may have a
            role in stress-induced neuronal apoptosis. Alternatively spliced
            transcript variants encoding different isoforms have been found for
            this gene. A recent study provided evidence for translational
            readthrough in this gene, and expression of an additional
            C-terminally extended isoform via the use of an alternative
            in-frame translation termination codon. [provided by RefSeq, Dec
            2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784646.1309172.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN01164131,
                                           SAMN01164138 [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..426
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 49.61 cM"
     Protein         1..426
                     /product="mitogen-activated protein kinase 10 isoform 3"
                     /EC_number="2.7.11.24"
                     /note="JNK3 beta1 protein kinase; JNK3 beta2 protein
                     kinase; MAP kinase 10; MAP kinase p49 3F12; c-Jun
                     N-terminal kinase 3; stress-activated protein kinase JNK3;
                     SAPK/Erk/kinase 2"
                     /calculated_mol_wt=47997
     Region          25..360
                     /region_name="STKc_JNK"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     c-Jun N-terminal Kinase; cd07850"
                     /db_xref="CDD:270840"
     Site            order(32..38,40,53,55,72,86,108..114,116..117,151,153,
                     155..156,158,168..169,172,183,185..188,190,227)
                     /site_type="active"
                     /db_xref="CDD:270840"
     Site            order(32..38,40,53,55,86,108..114,158,168)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270840"
     Site            order(72,116,151,153,172,183,185..188,190,227)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270840"
     Site            order(112,118,127,130,159..163,323..324,326,329)
                     /site_type="other"
                     /note="KIM docking site [polypeptide binding]"
                     /db_xref="CDD:270840"
     Site            order(168..178,182..190)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270840"
     CDS             1..426
                     /gene="Mapk10"
                     /gene_synonym="C230008H04Rik; JNK3; JNK3B1; JNK3B2;
                     p493F12; p54bSAPK; SAPK(beta); Serk2"
                     /coded_by="NM_001407579.1:655..1935"
                     /note="isoform 3 is encoded by transcript variant 14"
                     /db_xref="GeneID:26414"
                     /db_xref="MGI:MGI:1346863"
ORIGIN      
        1 mskskvdnqf ysvevgdstf tvlkryqnlk pigsgaqgiv caaydavldr nvaikklsrp
       61 fqnqthakra yrelvlmkcv nhkniislln vftpqktlee fqdvylvmel mdanlcqviq
      121 meldhermsy llyqmlcgik hlhsagiihr dlkpsnivvk sdctlkildf glartagtsf
      181 mmtpyvvtry yrapevilgm gykenvdiws vgcimgemvr hkilfpgrdy idqwnkvieq
      241 lgtpcpefmk klqptvrnyv enrpkyaglt fpklfpdslf padsehnklk asqardllsk
      301 mlvidpakri svddalqhpy invwydpaev eapppqiydk qlderehtie ewkeliykev
      361 mnseektkng vvkgqpspsg aavnsseslp psssvndiss mstdqtlasd tdssleasag
      421 plgccr
//
LOCUS       NP_001297542             472 aa            linear   ROD 09-OCT-2023
DEFINITION  mixed lineage kinase domain-like protein isoform 1 [Mus musculus].
ACCESSION   NP_001297542 XP_006531504
VERSION     NP_001297542.1
DBSOURCE    REFSEQ: accession NM_001310613.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 472)
  AUTHORS   Garnish SE, Martin KR, Kauppi M, Jackson VE, Ambrose R, Eng VV,
            Chiou S, Meng Y, Frank D, Tovey Crutchfield EC, Patel KM, Jacobsen
            AV, Atkin-Smith GK, Di Rago L, Doerflinger M, Horne CR, Hall C,
            Young SN, Cook M, Athanasopoulos V, Vinuesa CG, Lawlor KE, Wicks
            IP, Ebert G, Ng AP, Slade CA, Pearson JS, Samson AL, Silke J,
            Murphy JM and Hildebrand JM.
  TITLE     A common human MLKL polymorphism confers resistance to negative
            regulation by phosphorylation
  JOURNAL   Nat Commun 14 (1), 6046 (2023)
   PUBMED   37770424
  REMARK    GeneRIF: A common human MLKL polymorphism confers resistance to
            negative regulation by phosphorylation.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 472)
  AUTHORS   Wang S and Xu M.
  TITLE     RIP3/MLKL regulates necroptosis via activating 4EBP1-eIF4E pathway
  JOURNAL   Zhong Nan Da Xue Xue Bao Yi Xue Ban 48 (7), 979-985 (2023)
   PUBMED   37724400
  REMARK    GeneRIF: RIP3/MLKL regulates necroptosis via activating 4EBP1-eIF4E
            pathway.
REFERENCE   3  (residues 1 to 472)
  AUTHORS   Meng H, Zhao Y, Li Y, Fan H, Yi X, Meng X, Wang P, Fu F, Wu S and
            Wang Y.
  TITLE     Evidence for developmental vascular-associated necroptosis and its
            contribution to venous-lymphatic endothelial differentiation
  JOURNAL   Front Cell Dev Biol 11, 1229788 (2023)
   PUBMED   37576598
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 472)
  AUTHORS   Yan M, Li H, Xu S, Wu J, Li J, Xiao C, Mo C and Ding BS.
  TITLE     Targeting Endothelial Necroptosis Disrupts Profibrotic
            Endothelial-Hepatic Stellate Cells Crosstalk to Alleviate Liver
            Fibrosis in Nonalcoholic Steatohepatitis
  JOURNAL   Int J Mol Sci 24 (14), 11313 (2023)
   PUBMED   37511074
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 472)
  AUTHORS   Vucur M, Ghallab A, Schneider AT, Adili A, Cheng M, Castoldi M,
            Singer MT, Buttner V, Keysberg LS, Kusgens L, Kohlhepp M, Gorg B,
            Gallage S, Barragan Avila JE, Unger K, Kordes C, Leblond AL,
            Albrecht W, Loosen SH, Lohr C, Jordens MS, Babler A, Hayat S,
            Schumacher D, Koenen MT, Govaere O, Boekschoten MV, Jors S,
            Villacorta-Martin C, Mazzaferro V, Llovet JM, Weiskirchen R, Kather
            JN, Starlinger P, Trauner M, Luedde M, Heij LR, Neumann UP, Keitel
            V, Bode JG, Schneider RK, Tacke F, Levkau B, Lammers T, Fluegen G,
            Alexandrov T, Collins AL, Nelson G, Oakley F, Mann DA, Roderburg C,
            Longerich T, Weber A, Villanueva A, Samson AL, Murphy JM, Kramann
            R, Geisler F, Costa IG, Hengstler JG, Heikenwalder M and Luedde T.
  TITLE     Sublethal necroptosis signaling promotes inflammation and liver
            cancer
  JOURNAL   Immunity 56 (7), 1578-1595 (2023)
   PUBMED   37329888
REFERENCE   6  (residues 1 to 472)
  AUTHORS   Wu J, Huang Z, Ren J, Zhang Z, He P, Li Y, Ma J, Chen W, Zhang Y,
            Zhou X, Yang Z, Wu SQ, Chen L and Han J.
  TITLE     Mlkl knockout mice demonstrate the indispensable role of Mlkl in
            necroptosis
  JOURNAL   Cell Res 23 (8), 994-1006 (2013)
   PUBMED   23835476
  REMARK    GeneRIF: Neither Mlkl nor Rip3 deficiency provided protection
            against polymicrobial sepsis-induced animal death in the study of
            septic shock induced by CLP.
REFERENCE   7  (residues 1 to 472)
  AUTHORS   Chen W, Zhou Z, Li L, Zhong CQ, Zheng X, Wu X, Zhang Y, Ma H, Huang
            D, Li W, Xia Z and Han J.
  TITLE     Diverse sequence determinants control human and mouse receptor
            interacting protein 3 (RIP3) and mixed lineage kinase domain-like
            (MLKL) interaction in necroptotic signaling
  JOURNAL   J Biol Chem 288 (23), 16247-16261 (2013)
   PUBMED   23612963
  REMARK    GeneRIF: the importance of the RIP3-MLKL interaction in the
            formation of functional necrosomes and suggest that translocation
            of necrosomes to mitochondria-associated membranes is essential for
            necroptosis signaling.
REFERENCE   8  (residues 1 to 472)
  AUTHORS   Zhao J, Jitkaew S, Cai Z, Choksi S, Li Q, Luo J and Liu ZG.
  TITLE     Mixed lineage kinase domain-like is a key receptor interacting
            protein 3 downstream component of TNF-induced necrosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (14), 5322-5327 (2012)
   PUBMED   22421439
REFERENCE   9  (residues 1 to 472)
  AUTHORS   Sun L, Wang H, Wang Z, He S, Chen S, Liao D, Wang L, Yan J, Liu W,
            Lei X and Wang X.
  TITLE     Mixed lineage kinase domain-like protein mediates necrosis
            signaling downstream of RIP3 kinase
  JOURNAL   Cell 148 (1-2), 213-227 (2012)
   PUBMED   22265413
  REMARK    GeneRIF: Findings implicate MLKL as a key mediator of necrosis
            signaling downstream of the kinase RIP3.
REFERENCE   10 (residues 1 to 472)
  AUTHORS   Bisson N, Tremblay M, Robinson F, Kaplan DR, Trusko SP and Moss T.
  TITLE     Mice lacking both mixed-lineage kinase genes Mlk1 and Mlk2 retain a
            wild type phenotype
  JOURNAL   Cell Cycle 7 (7), 909-916 (2008)
   PUBMED   18414056
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC163625.5, BY740989.1,
            AK018636.1 and BY467591.1.
            
            On Jul 16, 2015 this sequence version replaced XP_006531504.1.
            
            Summary: This gene belongs to the protein kinase superfamily. The
            encoded protein contains a protein kinase-like domain; however, is
            thought to lack protein kinase activity. This protein plays a
            critical role in tumor necrosis factor (TNF)-induced necroptosis, a
            programmed cell death process, via interaction with
            receptor-interacting protein 3 (Rip3), which is a key signaling
            molecule in necroptosis pathway. Knockout of this gene in mice
            showed that it is essential for necroptosis. Alternatively spliced
            transcript variants have been found for this gene. [provided by
            RefSeq, Sep 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK018636.1, SRR13422586.194038.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 57.98 cM"
     Protein         1..472
                     /product="mixed lineage kinase domain-like protein isoform
                     1"
                     /note="mixed lineage kinase domain-like protein"
                     /calculated_mol_wt=54187
     Region          1..143
                     /region_name="N-terminal bundle and brace (NBB), mediates
                     INSP6 binding. /evidence=ECO:0000250|UniProtKB:Q8NB16"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D2Y4.1)"
     Region          5..143
                     /region_name="MLKL_NTD"
                     /note="N-terminal domain of mixed lineage kinase
                     domain-like protein (MLKL) and similar proteins; cd21037"
                     /db_xref="CDD:411030"
     Site            124
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8NB16; propagated from
                     UniProtKB/Swiss-Prot (Q9D2Y4.1)"
     Region          130..>179
                     /region_name="COG7"
                     /note="Golgi complex component 7 (COG7); pfam10191"
                     /db_xref="CDD:431125"
     Region          198..446
                     /region_name="PKc_like"
                     /note="Protein Kinases, catalytic domain; cl21453"
                     /db_xref="CDD:451246"
     Site            345
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by RIPK3.
                     /evidence=ECO:0000269|PubMed:24012422,
                     ECO:0000269|PubMed:24095729; propagated from
                     UniProtKB/Swiss-Prot (Q9D2Y4.1)"
     Site            347
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by RIPK3.
                     /evidence=ECO:0000269|PubMed:24012422,
                     ECO:0000269|PubMed:24095729; propagated from
                     UniProtKB/Swiss-Prot (Q9D2Y4.1)"
     Site            349
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by RIPK3.
                     /evidence=ECO:0000269|PubMed:24012422,
                     ECO:0000269|PubMed:24095729; propagated from
                     UniProtKB/Swiss-Prot (Q9D2Y4.1)"
     Site            352
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by RIPK3.
                     /evidence=ECO:0000269|PubMed:24095729; propagated from
                     UniProtKB/Swiss-Prot (Q9D2Y4.1)"
     CDS             1..472
                     /gene="Mlkl"
                     /gene_synonym="9130019I15Rik"
                     /coded_by="NM_001310613.1:385..1803"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS80932.1"
                     /db_xref="GeneID:74568"
                     /db_xref="MGI:MGI:1921818"
ORIGIN      
        1 mdklgqiikl gqliyeqcek mkycrkqcqr lgnrvhgllq plqrlqaqgk knlpdditaa
       61 lgrfdevlke anqqiekfsk kshiwkfvsv gndkilfhev neklrdvwee lllllqvyhw
      121 ntvsdvsqpa swqqedrqda eedgnenmkv ilmqlqisve einktlkqcs lkptqeipqd
      181 lqikeipkeh lgppwtklkt skmstiyrge yhrspvtikv fnnpqaesvg ivrftfndei
      241 ktmkkfdspn ilrifgicid qtvkppefsi vmeycelgtl relldrekdl tmsvrsllvl
      301 raarglyrlh hsetlhrnis sssflvaggy qvklagfels ktqnsisrta kstkaersss
      361 tiyvsperlk npfclydika eiysfgivlw eiatgkipfe gcdskkirel vaedkkqepv
      421 gqdcpellre iinecrahep sqrpsvdgrs lsgreriler lsaveestdk kv
//
LOCUS       NP_848706                700 aa            linear   ROD 09-OCT-2023
DEFINITION  pro-neuregulin-1, membrane-bound isoform isoform 1 [Mus musculus].
ACCESSION   NP_848706 XP_620642 XP_898476 XP_905896 XP_905899 XP_905900
            XP_905904 XP_905910 XP_905914 XP_905917 XP_905925 XP_905928
            XP_918086 XP_927655 XP_927663 XP_927670 XP_927687 XP_927696
            XP_927700 XP_927710 XP_927716 XP_927722 XP_927729 XP_991369
            XP_991396 XP_991424 XP_991456 XP_991488 XP_991519 XP_991552
            XP_991586 XP_991659 XP_991699 XP_991739 XP_991776 XP_991819
            XP_993308 XP_995342 XP_995372
VERSION     NP_848706.2
DBSOURCE    REFSEQ: accession NM_178591.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 700)
  AUTHORS   Mikami Y, Iwase F, Ohshima D, Tomida T and Adachi-Akahane S.
  TITLE     Compensatory role of neuregulin-1 in diabetic cardiomyopathy
  JOURNAL   J Pharmacol Sci 153 (3), 130-141 (2023)
   PUBMED   37770154
  REMARK    GeneRIF: Compensatory role of neuregulin-1 in diabetic
            cardiomyopathy.
REFERENCE   2  (residues 1 to 700)
  AUTHORS   Qiao XY, Wang Y, Zhang W, Li Q, Liu C, Dao JJ, Qiao CM, Cui C, Shen
            YQ and Zhao WJ.
  TITLE     Involvement of CXCL10 in Neuronal Damage under the Condition of
            Spinal Cord Injury and the Potential Therapeutic Effect of Nrg1
  JOURNAL   J Integr Neurosci 22 (4), 96 (2023)
   PUBMED   37519170
  REMARK    GeneRIF: Involvement of CXCL10 in Neuronal Damage under the
            Condition of Spinal Cord Injury and the Potential Therapeutic
            Effect of Nrg1.
REFERENCE   3  (residues 1 to 700)
  AUTHORS   Liu H, Lu P, He S, Luo Y, Fang Y, Benkaci S, Wu B, Wang Y and Zhou
            B.
  TITLE     beta-Catenin regulates endocardial cushion growth by suppressing
            p21
  JOURNAL   Life Sci Alliance 6 (9), e202302163 (2023)
   PUBMED   37385754
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 700)
  AUTHORS   Kong L, Hassinan CW, Gerstner F, Buettner JM, Petigrow JB, Valdivia
            DO, Chan-Cortes MH, Mistri A, Cao A, McGaugh SA, Denton M, Brown S,
            Ross J, Schwab MH, Simon CM and Sumner CJ.
  TITLE     Boosting neuregulin 1 type-III expression hastens SMA motor axon
            maturation
  JOURNAL   Acta Neuropathol Commun 11 (1), 53 (2023)
   PUBMED   36997967
  REMARK    GeneRIF: Boosting neuregulin 1 type-III expression hastens SMA
            motor axon maturation.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 700)
  AUTHORS   Zhang X, Xiao G, Johnson C, Cai Y, Horowitz ZK, Mennicke C, Coffey
            R, Haider M, Threadgill D, Eliscu R, Oldham MC, Greenbaum A and
            Ghashghaei HT.
  TITLE     Bulk and mosaic deletions of Egfr reveal regionally defined
            gliogenesis in the developing mouse forebrain
  JOURNAL   iScience 26 (3), 106242 (2023)
   PUBMED   36915679
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 700)
  AUTHORS   Gassmann M, Casagranda F, Orioli D, Simon H, Lai C, Klein R and
            Lemke G.
  TITLE     Aberrant neural and cardiac development in mice lacking the ErbB4
            neuregulin receptor
  JOURNAL   Nature 378 (6555), 390-394 (1995)
   PUBMED   7477376
REFERENCE   7  (residues 1 to 700)
  AUTHORS   Meyer,D. and Birchmeier,C.
  TITLE     Multiple essential functions of neuregulin in development
  JOURNAL   Nature 378 (6555), 386-390 (1995)
   PUBMED   7477375
  REMARK    Erratum:[Nature 1995 Dec 14;378(6558):753]
REFERENCE   8  (residues 1 to 700)
  AUTHORS   Moscoso LM, Chu GC, Gautam M, Noakes PG, Merlie JP and Sanes JR.
  TITLE     Synapse-associated expression of an acetylcholine receptor-inducing
            protein, ARIA/heregulin, and its putative receptors, ErbB2 and
            ErbB3, in developing mammalian muscle
  JOURNAL   Dev Biol 172 (1), 158-169 (1995)
   PUBMED   7589796
REFERENCE   9  (residues 1 to 700)
  AUTHORS   Yang Y, Spitzer E, Meyer D, Sachs M, Niemann C, Hartmann G, Weidner
            KM, Birchmeier C and Birchmeier W.
  TITLE     Sequential requirement of hepatocyte growth factor and neuregulin
            in the morphogenesis and differentiation of the mammary gland
  JOURNAL   J Cell Biol 131 (1), 215-226 (1995)
   PUBMED   7559778
REFERENCE   10 (residues 1 to 700)
  AUTHORS   Ho WH, Armanini MP, Nuijens A, Phillips HS and Osheroff PL.
  TITLE     Sensory and motor neuron-derived factor. A novel heregulin variant
            highly expressed in sensory and motor neurons
  JOURNAL   J Biol Chem 270 (24), 14523-14532 (1995)
   PUBMED   7782315
  REMARK    Erratum:[J Biol Chem. 1995 Nov 3;270(44):26722. PMID: 7592900]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY238526.1, AC132407.3, AK141037.1, AY648975.1 and AC127374.4.
            
            On or before Feb 3, 2007 this sequence version replaced
            XP_905896.1, XP_995372.1, XP_995342.1, XP_898476.1, XP_905899.1,
            XP_905904.1, XP_905910.1, XP_905928.1, XP_905925.1, XP_905914.1,
            XP_905917.1, XP_905900.1, XP_927655.1, XP_927729.1, XP_927722.1,
            XP_927700.1, XP_918086.1, XP_927663.1, XP_927670.1, XP_927687.1,
            XP_620642.3, XP_927716.1, XP_927710.1, XP_993308.1, XP_927696.1,
            XP_991776.1, XP_991739.1, XP_991699.1, XP_991819.1, XP_991488.1,
            XP_991586.1, XP_991369.1, XP_991552.1, XP_991456.1, XP_991659.1,
            XP_991424.1, XP_991396.1, XP_991519.1, NP_848706.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC151113.1, AY648975.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..700
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 18.75 cM"
     Protein         1..700
                     /product="pro-neuregulin-1, membrane-bound isoform isoform
                     1"
                     /note="heregulin; type III neuregulin 1; type I neuregulin
                     1; pro-neuregulin-1, membrane-bound isoform"
                     /calculated_mol_wt=76374
     Region          245..275
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          327..682
                     /region_name="Neuregulin"
                     /note="Neuregulin family; pfam02158"
                     /db_xref="CDD:426627"
     CDS             1..700
                     /gene="Nrg1"
                     /gene_synonym="6030402G23Rik; ARIA; D230005F13Rik; GGF;
                     GGFII; Hgl; HRG; HRGalpha; NDF; Pro-NRG1; SMDF"
                     /coded_by="NM_178591.3:641..2743"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS40315.1"
                     /db_xref="GeneID:211323"
                     /db_xref="MGI:MGI:96083"
ORIGIN      
        1 meiyppdmse gaggrsssps tqlsadpsld glpaaehmpd thtedgrspg llglavpccv
       61 cleaerlrgc lnsekicivp ilaclvslcl ciaglkwvfv dkifeydspt hldpgglgqd
      121 pvisldptaa savlvsseay tspvskaqse aeahvtgqgd hvavasepsa vptrknrlsa
      181 fpplhstppp fpspartpev rtpksgtqpq ttetnlqtap klstststtg tshlikcaek
      241 ektfcvngge cfmvkdlsnp srylckcpne ftgdrcqnyv masfykhlgi efmeaeelyq
      301 krvltitgic iallvvgimc vvaycktkkq rqklhdrlrq slrsernnmv niangphhpn
      361 pppenvqlvn qyvsknviss ehiverevet sfstshytst ahhsttvtqt pshswsnght
      421 esiiseshsv immssvensr hsspaggprg rlhglggpre cnsflrhare tpdsyrdsph
      481 seryvsamtt parmspvdfh tpsspkspps emsppvssmt vsmpsvavsp fveeerplll
      541 vtpprlrekk ydhhpqqlns fhhnpahqst slppsplriv edeeyettqe yepiqepikk
      601 vtnsrrakrt kpnghianrl emdsnpssvs snsesetede rvgedtpflg iqnplaasle
      661 vapafrlaes rtnpagrfst qeelqarlss vianqdpiav
//
LOCUS       NP_001297614             464 aa            linear   ROD 09-OCT-2023
DEFINITION  mitogen-activated protein kinase 10 isoform 4 [Mus musculus].
ACCESSION   NP_001297614 XP_006535009 XP_017176375
VERSION     NP_001297614.1
DBSOURCE    REFSEQ: accession NM_001310685.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 464)
  AUTHORS   Priego M, Noriega L, Kalinin S, Hoffman LM, Feinstein DL and
            Morfini G.
  TITLE     Genetic deletion of c-Jun amino-terminal kinase 3 (JNK3) modestly
            increases disease severity in a mouse model of multiple sclerosis
  JOURNAL   J Neuroimmunol 382, 578152 (2023)
   PUBMED   37454525
  REMARK    GeneRIF: Genetic deletion of c-Jun amino-terminal kinase 3 (JNK3)
            modestly increases disease severity in a mouse model of multiple
            sclerosis.
REFERENCE   2  (residues 1 to 464)
  AUTHORS   Liu F, Deng Y, Zhao Y, Li Z, Gao J, Zhang Y, Yang X, Liu Y and Xia
            Y.
  TITLE     Time series RNA-seq analysis identifies MAPK10 as a critical gene
            in diabetes mellitus-induced atrial fibrillation in mice
  JOURNAL   J Mol Cell Cardiol 168, 70-82 (2022)
   PUBMED   35489387
  REMARK    GeneRIF: Time series RNA-seq analysis identifies MAPK10 as a
            critical gene in diabetes mellitus-induced atrial fibrillation in
            mice.
REFERENCE   3  (residues 1 to 464)
  AUTHORS   Cunningham JG, Scripter JD, Nti SA and Tucker ES.
  TITLE     Early construction of the thalamocortical axon pathway requires
            c-Jun N-terminal kinase signaling within the ventral forebrain
  JOURNAL   Dev Dyn 251 (3), 459-480 (2022)
   PUBMED   34494344
REFERENCE   4  (residues 1 to 464)
  AUTHORS   Goodwani S, Fernandez C, Acton PJ, Buggia-Prevot V, McReynolds ML,
            Ma J, Hu CH, Hamby ME, Jiang Y, Le K, Soth MJ, Jones P and Ray WJ.
  TITLE     Dual Leucine Zipper Kinase Is Constitutively Active in the Adult
            Mouse Brain and Has Both Stress-Induced and Homeostatic Functions
  JOURNAL   Int J Mol Sci 21 (14), 4849 (2020)
   PUBMED   32659913
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 464)
  AUTHORS   Loughran G, Chou MY, Ivanov IP, Jungreis I, Kellis M, Kiran AM,
            Baranov PV and Atkins JF.
  TITLE     Evidence of efficient stop codon readthrough in four mammalian
            genes
  JOURNAL   Nucleic Acids Res 42 (14), 8928-8938 (2014)
   PUBMED   25013167
REFERENCE   6  (residues 1 to 464)
  AUTHORS   Beier H and Grimm M.
  TITLE     Misreading of termination codons in eukaryotes by natural nonsense
            suppressor tRNAs
  JOURNAL   Nucleic Acids Res 29 (23), 4767-4782 (2001)
   PUBMED   11726686
  REMARK    Review article
REFERENCE   7  (residues 1 to 464)
  AUTHORS   Yang DD, Kuan CY, Whitmarsh AJ, Rincon M, Zheng TS, Davis RJ, Rakic
            P and Flavell RA.
  TITLE     Absence of excitotoxicity-induced apoptosis in the hippocampus of
            mice lacking the Jnk3 gene
  JOURNAL   Nature 389 (6653), 865-870 (1997)
   PUBMED   9349820
REFERENCE   8  (residues 1 to 464)
  AUTHORS   Casanova E, Garate C, Ovalle S, Calvo P and Chinchetru MA.
  TITLE     Identification of four splice variants of the mouse
            stress-activated protein kinase JNK/SAPK alpha-isoform
  JOURNAL   Neuroreport 7 (7), 1320-1324 (1996)
   PUBMED   8817558
REFERENCE   9  (residues 1 to 464)
  AUTHORS   Martin JH, Mohit AA and Miller CA.
  TITLE     Developmental expression in the mouse nervous system of the p493F12
            SAP kinase
  JOURNAL   Brain Res Mol Brain Res 35 (1-2), 47-57 (1996)
   PUBMED   8717339
REFERENCE   10 (residues 1 to 464)
  AUTHORS   Suzuki J, Yoshida S, Chen ZL, Momota Y, Kato K, Hirata A and
            Shiosaka S.
  TITLE     Ontogeny of neuropsin mRNA expression in the mouse brain
  JOURNAL   Neurosci Res 23 (4), 345-351 (1995)
   PUBMED   8602273
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC160244.11, AC123664.15,
            AC137121.9 and AC125252.7.
            
            On or before Jun 6, 2022 this sequence version replaced
            XP_017176375.1, XP_006535009.1.
            
            Summary: The protein encoded by this gene is a member of the MAP
            kinase family. MAP kinases act as integration points for multiple
            biochemical signals, and thus are involved in a wide variety of
            cellular processes, such as proliferation, differentiation,
            transcription regulation and development. This kinase is
            specifically expressed in a subset of neurons in the nervous system
            and is activated by threonine and tyrosine phosphorylation.
            Targeted deletion of this gene in mice suggests that it may have a
            role in stress-induced neuronal apoptosis. Alternatively spliced
            transcript variants encoding different isoforms have been found for
            this gene. A recent study provided evidence for translational
            readthrough in this gene, and expression of an additional
            C-terminally extended isoform via the use of an alternative
            in-frame translation termination codon. [provided by RefSeq, Dec
            2017].
            
            Transcript Variant: This variant (4) contains an alternate in-frame
            coding exon compared to variant 1. The resulting isoform (4, also
            known as JNK3 beta2) is the same length; however, contains a
            different 24 aa protein segment compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219381.307151.1,
                                           SRR17784647.287057.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849376 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..464
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 49.61 cM"
     Protein         1..464
                     /product="mitogen-activated protein kinase 10 isoform 4"
                     /EC_number="2.7.11.24"
                     /note="JNK3 beta1 protein kinase; JNK3 beta2 protein
                     kinase; MAP kinase 10; MAP kinase p49 3F12; c-Jun
                     N-terminal kinase 3; stress-activated protein kinase JNK3;
                     SAPK/Erk/kinase 2"
                     /calculated_mol_wt=52157
     Region          63..398
                     /region_name="STKc_JNK"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     c-Jun N-terminal Kinase; cd07850"
                     /db_xref="CDD:270840"
     Site            order(70..76,78,91,93,110,124,146..152,154..155,189,191,
                     193..194,196,206..207,210,221,223..226,228,265)
                     /site_type="active"
                     /db_xref="CDD:270840"
     Site            order(70..76,78,91,93,124,146..152,196,206)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270840"
     Site            order(110,154,189,191,210,221,223..226,228,265)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270840"
     Site            order(150,156,165,168,197..201,361..362,364,367)
                     /site_type="other"
                     /note="KIM docking site [polypeptide binding]"
                     /db_xref="CDD:270840"
     Site            order(206..216,220..228)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270840"
     CDS             1..464
                     /gene="Mapk10"
                     /gene_synonym="C230008H04Rik; JNK3; JNK3B1; JNK3B2;
                     p493F12; p54bSAPK; SAPK(beta); Serk2"
                     /coded_by="NM_001310685.2:517..1911"
                     /note="isoform 4 is encoded by transcript variant 4"
                     /db_xref="CCDS:CCDS80350.1"
                     /db_xref="GeneID:26414"
                     /db_xref="MGI:MGI:1346863"
ORIGIN      
        1 mslhflyycs eptldvkiaf cqgfdkhvdv ssiakhynms kskvdnqfys vevgdstftv
       61 lkryqnlkpi gsgaqgivca aydavldrnv aikklsrpfq nqthakrayr elvlmkcvnh
      121 kniisllnvf tpqktleefq dvylvmelmd anlcqviqme ldhermsyll yqmlcgikhl
      181 hsagiihrdl kpsnivvksd ctlkildfgl artagtsfmm tpyvvtryyr apevilgmgy
      241 kenvdlwsvg cimgemvkgt vlfpgtdhid qwnkvieqlg tpcpefmkkl qptvrnyven
      301 rpkyagltfp klfpdslfpa dsehnklkas qardllskml vidpakrisv ddalqhpyin
      361 vwydpaevea pppqiydkql derehtieew keliykevmn seektkngvv kgqpspsgaa
      421 vnsseslpps ssvndissms tdqtlasdtd ssleasagpl gccr
//
LOCUS       NP_001276392             750 aa            linear   ROD 09-OCT-2023
DEFINITION  neprilysin [Mus musculus].
ACCESSION   NP_001276392 XP_006501159
VERSION     NP_001276392.1
DBSOURCE    REFSEQ: accession NM_001289463.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 750)
  AUTHORS   Esser N, Mongovin SM, Mundinger TO, Barrow BM and Zraika S.
  TITLE     Neprilysin deficiency reduces hepatic gluconeogenesis in high
            fat-fed mice
  JOURNAL   Peptides 168, 171076 (2023)
   PUBMED   37572792
  REMARK    GeneRIF: Neprilysin deficiency reduces hepatic gluconeogenesis in
            high fat-fed mice.
REFERENCE   2  (residues 1 to 750)
  AUTHORS   Esser N, Mundinger TO, Barrow BM and Zraika S.
  TITLE     Acute Inhibition of Intestinal Neprilysin Enhances Insulin
            Secretion via GLP-1 Receptor Signaling in Male Mice
  JOURNAL   Endocrinology 164 (5) (2023)
   PUBMED   36964914
  REMARK    GeneRIF: Acute Inhibition of Intestinal Neprilysin Enhances Insulin
            Secretion via GLP-1 Receptor Signaling in Male Mice.
REFERENCE   3  (residues 1 to 750)
  AUTHORS   Ortiz C, Klein S, Reul WH, Magdaleno F, Groschl S, Dietrich P,
            Schierwagen R, Uschner FE, Torres S, Hieber C, Meier C, Kraus N,
            Tyc O, Brol M, Zeuzem S, Welsch C, Poglitsch M, Hellerbrand C,
            Alfonso-Prieto M, Mira F, Keller UAD, Tetzner A, Moore A, Walther T
            and Trebicka J.
  TITLE     Neprilysin-dependent neuropeptide Y cleavage in the liver promotes
            fibrosis by blocking NPY-receptor 1
  JOURNAL   Cell Rep 42 (2), 112059 (2023)
   PUBMED   36729833
  REMARK    GeneRIF: Neprilysin-dependent neuropeptide Y cleavage in the liver
            promotes fibrosis by blocking NPY-receptor 1.
REFERENCE   4  (residues 1 to 750)
  AUTHORS   Chen Y and Burnett JC Jr.
  TITLE     Biochemistry, Therapeutics, and Biomarker Implications of
            Neprilysin in Cardiorenal Disease
  JOURNAL   Clin Chem 63 (1), 108-115 (2017)
   PUBMED   28062615
  REMARK    Review article
REFERENCE   5  (residues 1 to 750)
  AUTHORS   Bayes-Genis A, Barallat J and Richards AM.
  TITLE     A Test in Context: Neprilysin: Function, Inhibition, and Biomarker
  JOURNAL   J Am Coll Cardiol 68 (6), 639-653 (2016)
   PUBMED   27491909
  REMARK    Review article
REFERENCE   6  (residues 1 to 750)
  AUTHORS   Turner AJ and Nalivaeva NN.
  TITLE     Proteinase dysbalance in pathology: the neprilysin (NEP) and
            angiotensin-converting enzyme (ACE) families
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 52 (4), 40-48 (2006)
   PUBMED   17543197
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   7  (residues 1 to 750)
  AUTHORS   Weil M, Itin A and Keshet E.
  TITLE     A role for mesenchyme-derived tachykinins in tooth and mammary
            gland morphogenesis
  JOURNAL   Development 121 (8), 2419-2428 (1995)
   PUBMED   7545574
REFERENCE   8  (residues 1 to 750)
  AUTHORS   Kalled SL, Siva N, Stein H and Reinherz EL.
  TITLE     The distribution of CD10 (NEP 24.11, CALLA) in humans and mice is
            similar in non-lymphoid organs but differs within the hematopoietic
            system: absence on murine T and B lymphoid progenitors
  JOURNAL   Eur J Immunol 25 (3), 677-687 (1995)
   PUBMED   7705396
REFERENCE   9  (residues 1 to 750)
  AUTHORS   Watson ML, Rao JK, Gilkeson GS, Ruiz P, Eicher EM, Pisetsky DS,
            Matsuzawa A, Rochelle JM and Seldin MF.
  TITLE     Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis
            gene to disease manifestations and renal disease-modifying loci
  JOURNAL   J Exp Med 176 (6), 1645-1656 (1992)
   PUBMED   1460423
REFERENCE   10 (residues 1 to 750)
  AUTHORS   Chen CY, Salles G, Seldin MF, Kister AE, Reinherz EL and Shipp MA.
  TITLE     Murine common acute lymphoblastic leukemia antigen (CD10 neutral
            endopeptidase 24.11). Molecular characterization, chromosomal
            localization, and modeling of the active site
  JOURNAL   J Immunol 148 (9), 2817-2825 (1992)
   PUBMED   1374101
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121993.2, AK033824.1, AK031446.1 and AC121840.3.
            
            On Jan 22, 2014 this sequence version replaced XP_006501159.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK033824.1, BC034092.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..750
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 29.97 cM"
     Protein         1..750
                     /product="neprilysin"
                     /EC_number="3.4.24.11"
                     /note="common acute lymphoblastic leukemia antigen;
                     enkephalinase; atriopeptidase; neutral endopeptidase
                     24.11; skin fibroblast elastase"
                     /calculated_mol_wt=85571
     Site            4
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61391.3)"
     Site            6
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q61391.3)"
     Region          16..23
                     /region_name="Stop-transfer sequence.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61391.3)"
     Site            29..51
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61391.3)"
     Region          77..748
                     /region_name="M13"
                     /note="Peptidase family M13 includes neprilysin and
                     endothelin-converting enzyme I; cd08662"
                     /db_xref="CDD:341056"
     Site            order(107,537,542..545,564,580..581,584..585,588,647,690,
                     693..694,711..712,718)
                     /site_type="active"
                     /db_xref="CDD:341056"
     Site            145
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19349973; propagated from
                     UniProtKB/Swiss-Prot (Q61391.3)"
     Site            211
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q61391.3)"
     Site            285
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19349973; propagated from
                     UniProtKB/Swiss-Prot (Q61391.3)"
     Site            311
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19349973; propagated from
                     UniProtKB/Swiss-Prot (Q61391.3)"
     Site            325
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000250|UniProtKB:P08473; propagated from
                     UniProtKB/Swiss-Prot (Q61391.3)"
     Site            628
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000250|UniProtKB:P08473; propagated from
                     UniProtKB/Swiss-Prot (Q61391.3)"
     CDS             1..750
                     /gene="Mme"
                     /gene_synonym="6030454K05Rik; CALLA; CD10; NEP; SFE"
                     /coded_by="NM_001289463.1:239..2491"
                     /db_xref="CCDS:CCDS17381.1"
                     /db_xref="GeneID:17380"
                     /db_xref="MGI:MGI:97004"
ORIGIN      
        1 mgrsesqmdi tdinapkpkk kqrwtpleis lsvlvlllti iavtmialya tyddgickss
       61 dciksaarli qnmdasvepc tdffkyacgg wlkrnvipet ssrysnfdil rdelevilkd
      121 vlqepktedi vavqkaktly rscinesaid srggqpllkl lpdiygwpva sdnwdqtygt
      181 swtaeksiaq lnskygkkvl inffvgtddk nstqhiihfd qprlglpsrd yyectgiyke
      241 actayvdfmi svarlirqeq slpidenqls lemnkvmele keianattkp edrndpmlly
      301 nkmtlaklqn nfslevngks fswsnftnei mstvniniqn eeevvvyape yltklkpilt
      361 kysprdlqnl mswrfimdlv sslsrnykes rnafrkalyg ttsetatwrr canyvngnme
      421 navgrlyvea afageskhvv edliaqirev fiqtlddltw mdaetkkkae ekalaikeri
      481 gypddiisne nklnneylel nyredeyfen iiqnlkfsqs kqlkklrekv dkdewisgaa
      541 vvnafyssgr nqivfpagil qppffsaqqs nslnyggigm vigheithgf ddngrnfnkd
      601 gdlvdwwtqq sannfkdqsq cmvyqygnfs wdlaggqhln gintlgenia dnggigqayr
      661 ayqnyvkkng eekllpgldl nhkqlfflnf aqvwcgtyrp eyavnsiktd vhspgnfrii
      721 gtlqnsaefa dafhcrknsy mnperkcrvw
//
LOCUS       NP_032252                863 aa            linear   ROD 09-OCT-2023
DEFINITION  potassium/sodium hyperpolarization-activated cyclic
            nucleotide-gated channel 2 [Mus musculus].
ACCESSION   NP_032252 XP_990525
VERSION     NP_032252.1
DBSOURCE    REFSEQ: accession NM_008226.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 863)
  AUTHORS   Zheng Y, Shao S, Zhang Y, Yuan S, Xing Y, Wang J, Qi X, Cui K, Tong
            J, Liu F, Cui S, Wan Y and Yi M.
  TITLE     HCN2 Channels in the Ventral Hippocampal CA1 Regulate Nociceptive
            Hypersensitivity in Mice
  JOURNAL   Int J Mol Sci 24 (18), 13823 (2023)
   PUBMED   37762124
  REMARK    GeneRIF: HCN2 Channels in the Ventral Hippocampal CA1 Regulate
            Nociceptive Hypersensitivity in Mice.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 863)
  AUTHORS   Yan Y, Zhu M, Cao X, Xu G, Shen W, Li F, Zhang J, Luo L, Zhang X,
            Zhang D and Liu T.
  TITLE     Thalamocortical Circuit Controls Neuropathic Pain via Up-regulation
            of HCN2 in the Ventral Posterolateral Thalamus
  JOURNAL   Neurosci Bull 39 (5), 774-792 (2023)
   PUBMED   36538279
  REMARK    GeneRIF: Thalamocortical Circuit Controls Neuropathic Pain via
            Up-regulation of HCN2 in the Ventral Posterolateral Thalamus.
REFERENCE   3  (residues 1 to 863)
  AUTHORS   Kwon J, Choi YI, Jo HJ, Lee SH, Lee HK, Kim H, Moon JY and Jung SJ.
  TITLE     The Role of Prostaglandin E1 as a Pain Mediator through
            Facilitation of Hyperpolarization-Activated Cyclic Nucleotide-Gated
            Channel 2 via the EP2 Receptor in Trigeminal Ganglion Neurons of
            Mice
  JOURNAL   Int J Mol Sci 22 (24), 13534 (2021)
   PUBMED   34948328
  REMARK    GeneRIF: The Role of Prostaglandin E1 as a Pain Mediator through
            Facilitation of Hyperpolarization-Activated Cyclic Nucleotide-Gated
            Channel 2 via the EP2 Receptor in Trigeminal Ganglion Neurons of
            Mice.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 863)
  AUTHORS   Lyman KA, Han Y, Zhou C, Renteria I, Besing GL, Kurz JE and
            Chetkovich DM.
  TITLE     Hippocampal cAMP regulates HCN channel function on two time scales
            with differential effects on animal behavior
  JOURNAL   Sci Transl Med 13 (621), eabl4580 (2021)
   PUBMED   34818058
REFERENCE   5  (residues 1 to 863)
  AUTHORS   Schlusche AK, Vay SU, Kleinenkuhnen N, Sandke S, Campos-Martin R,
            Florio M, Huttner W, Tresch A, Roeper J, Rueger MA, Jakovcevski I,
            Stockebrand M and Isbrandt D.
  TITLE     Developmental HCN channelopathy results in decreased neural
            progenitor proliferation and microcephaly in mice
  JOURNAL   Proc Natl Acad Sci U S A 118 (35) (2021)
   PUBMED   34429357
REFERENCE   6  (residues 1 to 863)
  AUTHORS   Zong X, Stieber J, Ludwig A, Hofmann F and Biel M.
  TITLE     A single histidine residue determines the pH sensitivity of the
            pacemaker channel HCN2
  JOURNAL   J Biol Chem 276 (9), 6313-6319 (2001)
   PUBMED   11096117
REFERENCE   7  (residues 1 to 863)
  AUTHORS   Chen J, Mitcheson JS, Lin M and Sanguinetti MC.
  TITLE     Functional roles of charged residues in the putative voltage sensor
            of the HCN2 pacemaker channel
  JOURNAL   J Biol Chem 275 (46), 36465-36471 (2000)
   PUBMED   10962006
REFERENCE   8  (residues 1 to 863)
  AUTHORS   Ludwig A, Zong X, Jeglitsch M, Hofmann F and Biel M.
  TITLE     A family of hyperpolarization-activated mammalian cation channels
  JOURNAL   Nature 393 (6685), 587-591 (1998)
   PUBMED   9634236
REFERENCE   9  (residues 1 to 863)
  AUTHORS   Santoro B, Liu DT, Yao H, Bartsch D, Kandel ER, Siegelbaum SA and
            Tibbs GR.
  TITLE     Identification of a gene encoding a hyperpolarization-activated
            pacemaker channel of brain
  JOURNAL   Cell 93 (5), 717-729 (1998)
   PUBMED   9630217
REFERENCE   10 (residues 1 to 863)
  AUTHORS   Santoro B, Grant SG, Bartsch D and Kandel ER.
  TITLE     Interactive cloning with the SH3 domain of N-src identifies a new
            brain specific ion channel protein, with homology to eag and cyclic
            nucleotide-gated channels
  JOURNAL   Proc Natl Acad Sci U S A 94 (26), 14815-14820 (1997)
   PUBMED   9405696
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC151828.3,
            AF064873.1 and CX242892.1.
            
            On May 4, 2006 this sequence version replaced XP_990525.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ225122.1, AB154248.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..863
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     Protein         1..863
                     /product="potassium/sodium hyperpolarization-activated
                     cyclic nucleotide-gated channel 2"
                     /note="HAC-1; BCNG-2; brain cyclic nucleotide-gated
                     channel 2; hyperpolarization-activated cation channel 1"
                     /calculated_mol_wt=94591
     Region          1..131
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O88703.1)"
     Site            119
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (O88703.1)"
     Region          131..182
                     /region_name="Involved in subunit assembly"
                     /note="propagated from UniProtKB/Swiss-Prot (O88703.1)"
     Site            134
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9JKA9; propagated from
                     UniProtKB/Swiss-Prot (O88703.1)"
     Region          140..182
                     /region_name="Ion_trans_N"
                     /note="Ion transport protein N-terminal; pfam08412"
                     /db_xref="CDD:400630"
     Region          175..>661
                     /region_name="PLN03192"
                     /note="Voltage-dependent potassium channel; Provisional"
                     /db_xref="CDD:215625"
     Site            189..209
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O88703.1)"
     Site            214..234
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O88703.1)"
     Site            262..282
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O88703.1)"
     Site            291..311
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O88703.1)"
     Site            343..363
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O88703.1)"
     Site            380
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O88703.1)"
     Site            414..434
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O88703.1)"
     Region          517..625
                     /region_name="CAP_ED"
                     /note="effector domain of the CAP family of transcription
                     factors; members include CAP (or cAMP receptor protein
                     (CRP)), which binds cAMP, FNR (fumarate and nitrate
                     reduction), which uses an iron-sulfur cluster to sense
                     oxygen) and CooA, a heme containing CO...; cd00038"
                     /db_xref="CDD:237999"
     Site            order(581..582,591..593)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:237999"
     Site            order(613..615,619..621)
                     /site_type="other"
                     /note="flexible hinge region"
                     /db_xref="CDD:237999"
     Site            641
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKG/PRKG2.
                     /evidence=ECO:0000269|PubMed:21347269; propagated from
                     UniProtKB/Swiss-Prot (O88703.1)"
     Site            726
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9JKA9; propagated from
                     UniProtKB/Swiss-Prot (O88703.1)"
     Site            728
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0007744|PubMed:24129315; propagated from
                     UniProtKB/Swiss-Prot (O88703.1)"
     Region          730..863
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O88703.1)"
     Site            743
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (O88703.1)"
     Site            750
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (O88703.1)"
     Site            757
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (O88703.1)"
     Region          <769..>862
                     /region_name="PRK07003"
                     /note="DNA polymerase III subunit gamma/tau"
                     /db_xref="CDD:235906"
     Site            840
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (O88703.1)"
     Site            842
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (O88703.1)"
     Site            847
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (O88703.1)"
     CDS             1..863
                     /gene="Hcn2"
                     /gene_synonym="BCNG2; HAC1; trls"
                     /coded_by="NM_008226.2:36..2627"
                     /db_xref="CCDS:CCDS23986.1"
                     /db_xref="GeneID:15166"
                     /db_xref="MGI:MGI:1298210"
ORIGIN      
        1 mdarggggrp gdspgttpap gppppppppa ppqpqpppap ppnpttpshp esadepgpra
       61 rlcsrdsact pgaakggang ecgrgepqcs pegpargpkv sfscrgaasg psaaeeagse
      121 eagpageprg sqasflqrqf gallqpgvnk fslrmfgsqk avereqervk sagawiihpy
      181 sdfrfywdft mllfmvgnli iipvgitffk dettapwivf nvvsdtfflm dlvlnfrtgi
      241 viednteiil dpekikkkyl rtwfvvdfvs sipvdyifli vekgidsevy ktaralrivr
      301 ftkilsllrl lrlsrliryi hqweeifhmt ydlasavmri cnlismmlll chwdgclqfl
      361 vpmlqdfpsd cwvsinnmvn hswselysfa lfkamshmlc igygrqapes mtdiwltmls
      421 mivgatcyam fighataliq sldssrrqyq ekykqveqym sfhklpadfr qkihdyyehr
      481 yqgkmfdeds ilgelngplr eeivnfncrk lvasmplfan adpnfvtaml tklkfevfqp
      541 gdyiiregti gkkmyfiqhg vvsvltkgnk emklsdgsyf geiclltrgr rtasvradty
      601 crlyslsvdn fnevleeypm mrrafetvai drldrigkkn sillhkvqhd lssgvfnnqe
      661 naiiqeivky dremvqqael gqrvglfppp pppqvtsaia tlqqavamsf cpqvarplvg
      721 plalgsprlv rrappgplpp aaspgppaas ppaapsspra prtspygvpg spatrvgpal
      781 parrlsrasr plsasqpslp hgvpapspaa sarpassstp rlgpaptart aapspdrrds
      841 aspgaasgld pldsarsrls snl
//
LOCUS       NP_001155218              94 aa            linear   ROD 09-OCT-2023
DEFINITION  tumor necrosis factor receptor superfamily member 12A isoform 2
            precursor [Mus musculus].
ACCESSION   NP_001155218
VERSION     NP_001155218.1
DBSOURCE    REFSEQ: accession NM_001161746.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 94)
  AUTHORS   Ruiz BI, Lowman XH, Yang Y, Fan Q, Wang T, Wu H, Hanse EA and Kong
            M.
  TITLE     Alpha-Ketoglutarate Regulates Tnfrsf12a/Fn14 Expression via Histone
            Modification and Prevents Cancer-Induced Cachexia
  JOURNAL   Genes (Basel) 14 (9), 1818 (2023)
   PUBMED   37761958
  REMARK    GeneRIF: Alpha-Ketoglutarate Regulates Tnfrsf12a/Fn14 Expression
            via Histone Modification and Prevents Cancer-Induced Cachexia.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 94)
  AUTHORS   Short C, Zhong A, Xu J, Mahdi E, Glazier A, Malkoff N, Noriega N,
            Yeo T, Asahina K and Wang KS.
  TITLE     TWEAK/FN14 promotes profibrogenic pathway activation in
            Prominin-1-expressing hepatic progenitor cells in biliary atresia
  JOURNAL   Hepatology 77 (5), 1639-1653 (2023)
   PUBMED   36626628
  REMARK    GeneRIF: TWEAK/FN14 promotes profibrogenic pathway activation in
            Prominin-1-expressing hepatic progenitor cells in biliary atresia.
REFERENCE   3  (residues 1 to 94)
  AUTHORS   Wang X, Lu M, Gu H, Xiao T, Hu G, Luo M, Guo X and Xia Y.
  TITLE     Conjugation of the Fn14 Ligand to a SMAC Mimetic Selectively
            Suppresses Experimental Squamous Cell Carcinoma in Mice
  JOURNAL   J Invest Dermatol 143 (2), 242-253 (2023)
   PUBMED   36063885
  REMARK    GeneRIF: Conjugation of the Fn14 Ligand to a SMAC Mimetic
            Selectively Suppresses Experimental Squamous Cell Carcinoma in
            Mice.
REFERENCE   4  (residues 1 to 94)
  AUTHORS   Tomaz da Silva M, Joshi AS, Koike TE, Roy A, Mathukumalli K,
            Sopariwala DH, Narkar VA and Kumar A.
  TITLE     Targeted ablation of Fn14 receptor improves exercise capacity and
            inhibits neurogenic muscle atrophy
  JOURNAL   FASEB J 36 (12), e22666 (2022)
   PUBMED   36412933
  REMARK    GeneRIF: Targeted ablation of Fn14 receptor improves exercise
            capacity and inhibits neurogenic muscle atrophy.
REFERENCE   5  (residues 1 to 94)
  AUTHORS   Ortega MA, Villiger RK, Harrison-Chau M, Lieu S, Tamashiro KK, Lee
            AJ, Fujimoto BA, Patwardhan GY, Kepler J and Fogelgren B.
  TITLE     Exocyst inactivation in urothelial cells disrupts autophagy and
            activates non-canonical NF-kappaB signaling
  JOURNAL   Dis Model Mech 15 (10) (2022)
   PUBMED   36004645
REFERENCE   6  (residues 1 to 94)
  AUTHORS   Polek TC, Talpaz M, Darnay BG and Spivak-Kroizman T.
  TITLE     TWEAK mediates signal transduction and differentiation of RAW264.7
            cells in the absence of Fn14/TweakR. Evidence for a second TWEAK
            receptor
  JOURNAL   J Biol Chem 278 (34), 32317-32323 (2003)
   PUBMED   12794080
  REMARK    GeneRIF: findings show that the Fn14/TWEAK receptor (TweakR) was
            not responsible for the osteoclastic effect of TWEAK on RAW cells
REFERENCE   7  (residues 1 to 94)
  AUTHORS   Brown SA, Richards CM, Hanscom HN, Feng SL and Winkles JA.
  TITLE     The Fn14 cytoplasmic tail binds
            tumour-necrosis-factor-receptor-associated factors 1, 2, 3 and 5
            and mediates nuclear factor-kappaB activation
  JOURNAL   Biochem J 371 (Pt 2), 395-403 (2003)
   PUBMED   12529173
  REMARK    GeneRIF: The cytoplasmic tail of this protein binds
            tumour-necrosis-factor-receptor-associated factors 1, 2, 3 and 5
            and mediates nuclear factor-kappaB activation.
REFERENCE   8  (residues 1 to 94)
  AUTHORS   Wiley SR, Cassiano L, Lofton T, Davis-Smith T, Winkles JA, Lindner
            V, Liu H, Daniel TO, Smith CA and Fanslow WC.
  TITLE     A novel TNF receptor family member binds TWEAK and is implicated in
            angiogenesis
  JOURNAL   Immunity 15 (5), 837-846 (2001)
   PUBMED   11728344
REFERENCE   9  (residues 1 to 94)
  AUTHORS   Feng SL, Guo Y, Factor VM, Thorgeirsson SS, Bell DW, Testa JR,
            Peifley KA and Winkles JA.
  TITLE     The Fn14 immediate-early response gene is induced during liver
            regeneration and highly expressed in both human and murine
            hepatocellular carcinomas
  JOURNAL   Am J Pathol 156 (4), 1253-1261 (2000)
   PUBMED   10751351
REFERENCE   10 (residues 1 to 94)
  AUTHORS   Meighan-Mantha RL, Hsu DK, Guo Y, Brown SA, Feng SL, Peifley KA,
            Alberts GF, Copeland NG, Gilbert DJ, Jenkins NA, Richards CM and
            Winkles JA.
  TITLE     The mitogen-inducible Fn14 gene encodes a type I transmembrane
            protein that modulates fibroblast adhesion and migration
  JOURNAL   J Biol Chem 274 (46), 33166-33176 (1999)
   PUBMED   10551889
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK160136.1, DV655788.1 and AI853177.1.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon compared to variant 1. The resulting isoform (2) has the same
            N- and C-termini but is shorter compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DV655788.1, AV453919.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN02415127 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..94
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 11.99 cM"
     Protein         1..94
                     /product="tumor necrosis factor receptor superfamily
                     member 12A isoform 2 precursor"
                     /note="tweak-receptor; FGF-inducible 14; fibroblast growth
                     factor-regulated protein 2; fibroblast growth
                     factor-inducible immediate-early response protein 14; type
                     I transmembrane protein Fn14"
                     /calculated_mol_wt=7225
     Region          1..94
                     /region_name="TNFRSF"
                     /note="Tumor necrosis factor receptor superfamily
                     (TNFRSF); cl22855"
                     /db_xref="CDD:451430"
     sig_peptide     1..27
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=2826
     CDS             1..94
                     /gene="Tnfrsf12a"
                     /gene_synonym="Fn14; HPIP; TWEAK-R; TweakR"
                     /coded_by="NM_001161746.1:30..314"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2"
                     /db_xref="CCDS:CCDS50011.1"
                     /db_xref="GeneID:27279"
                     /db_xref="MGI:MGI:1351484"
ORIGIN      
        1 masawprslp qilvlgfglv lmraaageqa pgaaappahf rllwpilgga lslvlvlalv
       61 ssflvwrrcr rrekfttpie etggegcpgv aliq
//
LOCUS       NP_064430                395 aa            linear   ROD 09-OCT-2023
DEFINITION  dihydroorotate dehydrogenase (quinone), mitochondrial precursor
            [Mus musculus].
ACCESSION   NP_064430
VERSION     NP_064430.1
DBSOURCE    REFSEQ: accession NM_020046.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 395)
  AUTHORS   Yang T, Shi X, Li S, Zhao Z, Wang J, Yu P, Li H, Wang R and Chen Z.
  TITLE     Targeting DHODH reveals therapeutic opportunities in ATRA-resistant
            acute promyelocytic leukemia
  JOURNAL   Biomed Pharmacother 166, 115314 (2023)
   PUBMED   37579695
  REMARK    GeneRIF: Targeting DHODH reveals therapeutic opportunities in
            ATRA-resistant acute promyelocytic leukemia.
REFERENCE   2  (residues 1 to 395)
  AUTHORS   Tu HF, Ko CJ, Lee CT, Lee CF, Lan SW, Lin HH, Lin HY, Ku CC, Lee
            DY, Chen IC, Chuang YH, Del Cano-Ochoa F, Ramon-Maiques S, Ho CC,
            Lee MS and Chang GD.
  TITLE     Afatinib Exerts Immunomodulatory Effects by Targeting the
            Pyrimidine Biosynthesis Enzyme CAD
  JOURNAL   Cancer Res 81 (12), 3270-3282 (2021)
   PUBMED   33771897
REFERENCE   3  (residues 1 to 395)
  AUTHORS   Styr B, Gonen N, Zarhin D, Ruggiero A, Atsmon R, Gazit N, Braun G,
            Frere S, Vertkin I, Shapira I, Harel M, Heim LR, Katsenelson M,
            Rechnitz O, Fadila S, Derdikman D, Rubinstein M, Geiger T, Ruppin E
            and Slutsky I.
  TITLE     Mitochondrial Regulation of the Hippocampal Firing Rate Set Point
            and Seizure Susceptibility
  JOURNAL   Neuron 102 (5), 1009-1024 (2019)
   PUBMED   31047779
  REMARK    GeneRIF: Knockdown of Dhodh reduced hippocampus mean firing rate.
REFERENCE   4  (residues 1 to 395)
  AUTHORS   Zurkirchen L, Varum S, Giger S, Klug A, Hausel J, Bossart R, Zemke
            M, Cantu C, Atak ZK, Zamboni N, Basler K and Sommer L.
  TITLE     Yin Yang 1 sustains biosynthetic demands during brain development
            in a stage-specific manner
  JOURNAL   Nat Commun 10 (1), 2192 (2019)
   PUBMED   31097699
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 395)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 395)
  AUTHORS   Mootha VK, Bunkenborg J, Olsen JV, Hjerrild M, Wisniewski JR, Stahl
            E, Bolouri MS, Ray HN, Sihag S, Kamal M, Patterson N, Lander ES and
            Mann M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   7  (residues 1 to 395)
  AUTHORS   Thomson TA, Spinella-Jaegle S, Francesconi E, Meakin C, Millet S,
            Flao KL, Hidden H and Ruuth E.
  TITLE     In vitro and in Vivo inhibition of immunoglobulin secretion by the
            immunosuppressive compound HR325 is reversed by exogenous uridine
  JOURNAL   Scand J Immunol 56 (1), 35-42 (2002)
   PUBMED   12100469
  REMARK    GeneRIF: immunosuppressive agent HR325 (an inhibitor of
            dihydroorotate dehydrogenase, DHODH) inhibits immunoglobulin (Ig)
            secretion both in vitro and in vivo and that this effect can be
            reverse with exogenous uridine
REFERENCE   8  (residues 1 to 395)
  AUTHORS   Ullrich A, Knecht W, Fries M and Loffler M.
  TITLE     Recombinant expression of N-terminal truncated mutants of the
            membrane bound mouse, rat and human flavoenzyme dihydroorotate
            dehydrogenase. A versatile tool to rate inhibitor effects?
  JOURNAL   Eur J Biochem 268 (6), 1861-1868 (2001)
   PUBMED   11248707
REFERENCE   9  (residues 1 to 395)
  AUTHORS   Knecht W, Henseling J and Loffler M.
  TITLE     Kinetics of inhibition of human and rat dihydroorotate
            dehydrogenase by atovaquone, lawsone derivatives, brequinar sodium
            and polyporic acid
  JOURNAL   Chem Biol Interact 124 (1), 61-76 (2000)
   PUBMED   10658902
REFERENCE   10 (residues 1 to 395)
  AUTHORS   Loffler,M.
  TITLE     On the role of dihydroorotate dehydrogenase in growth cessation of
            Ehrlich ascites tumor cells cultured under oxygen deficiency
  JOURNAL   Eur J Biochem 107 (1), 207-215 (1980)
   PUBMED   6249586
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125162.4 and BC045206.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC045206.1, AF029667.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..395
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 57.12 cM"
     Protein         1..395
                     /product="dihydroorotate dehydrogenase (quinone),
                     mitochondrial precursor"
                     /EC_number="1.3.5.2"
                     /note="dihydroorotate dehydrogenase, mitochondrial;
                     dihydroorotate dehydrogenase (quinone), mitochondrial;
                     DHOdehase; dihydroorotate oxidase"
                     /calculated_mol_wt=41403
     transit_peptide 1..10
                     /note="Mitochondrion, not cleaved. /evidence=ECO:0000250;
                     propagated from UniProtKB/Swiss-Prot (O35435.2)"
                     /calculated_mol_wt=1316
     Site            11..30
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O35435.2)"
     Region          43..373
                     /region_name="DHOD_2_like"
                     /note="Dihydroorotate dehydrogenase (DHOD) class 2. DHOD
                     catalyzes the oxidation of (S)-dihydroorotate to orotate.
                     This is the fourth step and the only redox reaction in the
                     de novo biosynthesis of UMP, the precursor of all
                     pyrimidine nucleotides. DHOD requires...; cd04738"
                     /db_xref="CDD:240089"
     Site            order(55,135)
                     /site_type="other"
                     /note="quinone interaction residues [chemical binding]"
                     /db_xref="CDD:240089"
     Site            order(95,99,119,144,146..148,211,214,216,254,282..284,305,
                     334,355..356)
                     /site_type="active"
                     /db_xref="CDD:240089"
     Site            order(99,214,254)
                     /site_type="active"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:240089"
     Site            order(119,144,211,254,282..283,305,334,355..356)
                     /site_type="other"
                     /note="FMN binding site [chemical binding]"
                     /db_xref="CDD:240089"
     Site            order(144,211,213,283..284)
                     /site_type="other"
                     /note="substrate binding site [chemical binding]"
                     /db_xref="CDD:240089"
     CDS             1..395
                     /gene="Dhodh"
                     /gene_synonym="2810417D19Rik"
                     /coded_by="NM_020046.3:302..1489"
                     /db_xref="CCDS:CCDS40471.1"
                     /db_xref="GeneID:56749"
                     /db_xref="MGI:MGI:1928378"
ORIGIN      
        1 mawrqlrkra ldaaiilggg gllftsylta tgddhfyaey lmpalqrlld pesahrlavr
       61 vislgllpra tfqdsnmlev rvlghkfrnp vgiaagfdkh geavdglykl gfgfvevgsv
      121 tpqpqegnpr prvfrlpedq avinrygfns hglsavehrl rarqqkqtql ttdglplgin
      181 lgknktsvda aadyvegvri lgpladylvv nvsspntagl rslqgktelr rllskvlqer
      241 dalkgpqkpa vlvkiapdlt aqdkediasv arelgidgli itnttvsrpv glqgalrset
      301 gglsgkplrd lstqtiremy altqgtipii gvggvssgqd alekiqagas lvqlytaltf
      361 lgppvvarvk releallker gfntvtdaig vdhrr
//
LOCUS       NP_001129537            1161 aa            linear   ROD 09-OCT-2023
DEFINITION  homeodomain-interacting protein kinase 2 isoform 1 [Mus musculus].
ACCESSION   NP_001129537
VERSION     NP_001129537.1
DBSOURCE    REFSEQ: accession NM_001136065.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1161)
  AUTHORS   Wang G, Ma Z, Song C, Wang X and Zhou Z.
  TITLE     miR-147b is an oncomiR acting synergistically with HIPK2 to promote
            pancreatic carcinogenesis
  JOURNAL   Cell Signal 111, 110840 (2023)
   PUBMED   37543099
  REMARK    GeneRIF: miR-147b is an oncomiR acting synergistically with HIPK2
            to promote pancreatic carcinogenesis.
REFERENCE   2  (residues 1 to 1161)
  AUTHORS   Zhong W, Hong C, Dong Y, Li Y, Xiao C and Liu X.
  TITLE     ASH2L Aggravates Fibrosis and Inflammation through HIPK2 in High
            Glucose-Induced Glomerular Mesangial Cells
  JOURNAL   Genes (Basel) 13 (12), 2244 (2022)
   PUBMED   36553510
  REMARK    GeneRIF: ASH2L Aggravates Fibrosis and Inflammation through HIPK2
            in High Glucose-Induced Glomerular Mesangial Cells.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1161)
  AUTHORS   Zhou Q, Meng D, Li F, Zhang X, Liu L, Zhu Y, Liu S, Xu M, Deng J,
            Lei Z, Sluijter JPG and Xiao J.
  TITLE     Inhibition of HIPK2 protects stress-induced pathological cardiac
            remodeling
  JOURNAL   EBioMedicine 85, 104274 (2022)
   PUBMED   36182775
  REMARK    GeneRIF: Inhibition of HIPK2 protects stress-induced pathological
            cardiac remodeling.
REFERENCE   4  (residues 1 to 1161)
  AUTHORS   Cheung KL, Jaganathan A, Hu Y, Xu F, Lejeune A, Sharma R, Caescu
            CI, Meslamani J, Vincek A, Zhang F, Lee K, Zaware N, Qayum AA, Ren
            C, Kaplan MH, He JC, Xiong H and Zhou MM.
  TITLE     HIPK2 directs cell type-specific regulation of STAT3
            transcriptional activity in Th17 cell differentiation
  JOURNAL   Proc Natl Acad Sci U S A 119 (14), e2117112119 (2022)
   PUBMED   35344430
  REMARK    GeneRIF: HIPK2 directs cell type-specific regulation of STAT3
            transcriptional activity in Th17 cell differentiation.
REFERENCE   5  (residues 1 to 1161)
  AUTHORS   Yu Q, Liu L, Zhang X, Chang H, Ma S, Xie Z, Tang S, Ju X, Zhu H,
            Shen B and Zhang Q.
  TITLE     MiR-221-3p targets HIPK2 to promote diabetic wound healing
  JOURNAL   Microvasc Res 140, 104306 (2022)
   PUBMED   34973299
  REMARK    GeneRIF: MiR-221-3p targets HIPK2 to promote diabetic wound
            healing.
REFERENCE   6  (residues 1 to 1161)
  AUTHORS   Hofmann TG, Mincheva A, Lichter P, Droge W and Schmitz ML.
  TITLE     Human homeodomain-interacting protein kinase-2 (HIPK2) is a member
            of the DYRK family of protein kinases and maps to chromosome
            7q32-q34
  JOURNAL   Biochimie 82 (12), 1123-1127 (2000)
   PUBMED   11120354
REFERENCE   7  (residues 1 to 1161)
  AUTHORS   Wang W, Link V and Green JM.
  TITLE     Identification and cloning of a CD43-associated serine/threonine
            kinase
  JOURNAL   Cell Immunol 205 (1), 34-39 (2000)
   PUBMED   11078605
REFERENCE   8  (residues 1 to 1161)
  AUTHORS   Ebling FJ, Brooks AN, Cronin AS, Ford H and Kerr JB.
  TITLE     Estrogenic induction of spermatogenesis in the hypogonadal mouse
  JOURNAL   Endocrinology 141 (8), 2861-2869 (2000)
   PUBMED   10919273
REFERENCE   9  (residues 1 to 1161)
  AUTHORS   Kim YH, Choi CY and Kim Y.
  TITLE     Covalent modification of the homeodomain-interacting protein kinase
            2 (HIPK2) by the ubiquitin-like protein SUMO-1
  JOURNAL   Proc Natl Acad Sci U S A 96 (22), 12350-12355 (1999)
   PUBMED   10535925
REFERENCE   10 (residues 1 to 1161)
  AUTHORS   Kim YH, Choi CY, Lee SJ, Conti MA and Kim Y.
  TITLE     Homeodomain-interacting protein kinases, a novel family of
            co-repressors for homeodomain transcription factors
  JOURNAL   J Biol Chem 273 (40), 25875-25879 (1998)
   PUBMED   9748262
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK016742.1, AF208292.1 and BM122543.2.
            
            Transcript Variant: This variant (1) has multiple differences
            compared to variant 2. These differences result in a distinct 5'
            UTR, and cause translation initiation at a downstream start codon,
            compared to variant 2. The encoded isoform (1) is shorter than
            isoform 2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF208292.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1161
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 17.85 cM"
     Protein         1..1161
                     /product="homeodomain-interacting protein kinase 2 isoform
                     1"
                     /EC_number="2.7.11.1"
                     /note="nuclear body-associated kinase 1; sialophorin
                     tail-associated nuclear serine/threonine-protein kinase"
                     /calculated_mol_wt=126670
     Region          176..530
                     /region_name="STKc_HIPK2"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     Homeodomain-Interacting Protein Kinase 2; cd14227"
                     /db_xref="CDD:271129"
     Site            order(198..202,206,219,221,235,254,270..273,276,278..279,
                     317,319,321..322,324,339,342,352,354..357,359,396)
                     /site_type="active"
                     /db_xref="CDD:271129"
     Site            order(198..202,206,219,221,254,270..273,276,317,319,
                     321..322,324,339)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271129"
     Site            order(235,278,317,319,342,352,354..357,359,396)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:271129"
     Site            338..359
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:271129"
     CDS             1..1161
                     /gene="Hipk2"
                     /gene_synonym="1110014O20Rik; B230339E18Rik; Stank"
                     /coded_by="NM_001136065.2:319..3804"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS51752.1"
                     /db_xref="GeneID:15258"
                     /db_xref="MGI:MGI:1314872"
ORIGIN      
        1 mashvqvfsp htlqssafcs vkklkvepss nwdmtgygsh skvysqskni ppsqpasttv
       61 stslpipnps lpyeqtiifp gstghivvts asstsvtgqv lggphnlmrr stvslldtyq
      121 kcglkrksee ientssvqii eehppmiqnn asgatvatat tstatsknsg snsegdyqlv
      181 qhevlcsmtn tyevleflgr gtfgqvvkcw krgtneivai kilknhpsya rqgqievsil
      241 arlstesadd ynfvrayecf qhknhtclvf emleqnlydf lkqnkfsplp lkyirpvlqq
      301 vatalmklks lglihadlkp enimlvdpsr qpyrvkvidf gsashvskav cstylqsryy
      361 rapeiilglp fceaidmwsl gcviaelflg wplypgasey dqiryisqtq glpaeyllsa
      421 gtkttrffnr dtdspyplwr lktpddheae tgikskeark yifnclddma qvnmttdleg
      481 sdmlvekadr refidllkkm ltidadkrvt pietlnhpfv tmthlldfph sahvkscfqn
      541 meickrrvnm ydtvnqsktp fithvapsts tnltmtfnnq lttvhnqpsa asmaavaprs
      601 mplqtgtaqi carpdpfqqa livcppgfqg lqaspskhag ysvrmenavp ivtqapgaqp
      661 lqiqpgllaq awpggaqqil lppawqqltg vathtsvqha avipetmagt qqladwrnth
      721 ahgshynpim qqpalltghv tlpaaqplnv gvahvmrqqp tsttssrksk qhqssvrnvs
      781 tcevtssqai sspqrskrvk entpprcamv hsspacstsv tcgwgdvass ttrerqrqti
      841 vipdtpsptv svitissdtd eeeeqkhapt stvskqrknv iscvtvhdsp ysdsssntsp
      901 ysvqqrtghn gtntldtkgg lenhctgnpr tiivpplktq asevlvecds lgpaisashh
      961 sssfksksss tvtstsghss gsssgaiayr qqrpgphfqq qqplnlsqaq qhmaadrtgs
     1021 hrrqqayitp tmaqapytfp hnspshgtvh phlaaaahlp tqphlytyta ptalgstgtv
     1081 ahlvasqgsa rhtvqhtayp asivhqvpvs mgprvlpspt ihpsqypaqf ahqtyisasp
     1141 astvytgypl spakvnqypy i
//
LOCUS       NP_666108                532 aa            linear   ROD 09-OCT-2023
DEFINITION  AT-rich interactive domain-containing protein 5A isoform 3 [Mus
            musculus].
ACCESSION   NP_666108
VERSION     NP_666108.2
DBSOURCE    REFSEQ: accession NM_145996.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 532)
  AUTHORS   Li X, Hua S, Fang D, Fei X, Tan Z, Zheng F, Wang W and Fang M.
  TITLE     RAGE deficiency ameliorates autoimmune hepatitis involving
            inhibition of IL-6 production via suppressing protein Arid5a in
            mice
  JOURNAL   Clin Exp Med 23 (6), 2167-2179 (2023)
   PUBMED   36454447
  REMARK    GeneRIF: RAGE deficiency ameliorates autoimmune hepatitis involving
            inhibition of IL-6 production via suppressing protein Arid5a in
            mice.
REFERENCE   2  (residues 1 to 532)
  AUTHORS   Taylor TC, Li Y, Li DD, Majumder S, McGeachy MJ, Biswas PS, Gingras
            S and Gaffen SL.
  TITLE     Arid5a Mediates an IL-17-Dependent Pathway That Drives Autoimmunity
            but Not Antifungal Host Defense
  JOURNAL   J Immunol 209 (6), 1138-1145 (2022)
   PUBMED   35940634
  REMARK    GeneRIF: Arid5a Mediates an IL-17-Dependent Pathway That Drives
            Autoimmunity but Not Antifungal Host Defense.
REFERENCE   3  (residues 1 to 532)
  AUTHORS   Catela C, Chen Y, Weng Y, Wen K and Kratsios P.
  TITLE     Control of spinal motor neuron terminal differentiation through
            sustained Hoxc8 gene activity
  JOURNAL   Elife 11, e70766 (2022)
   PUBMED   35315772
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 532)
  AUTHORS   Nyati KK, Hashimoto S, Singh SK, Tekguc M, Metwally H, Liu YC,
            Okuzaki D, Gemechu Y, Kang S and Kishimoto T.
  TITLE     The novel long noncoding RNA AU021063, induced by IL-6/Arid5a
            signaling, exacerbates breast cancer invasion and metastasis by
            stabilizing Trib3 and activating the Mek/Erk pathway
  JOURNAL   Cancer Lett 520, 295-306 (2021)
   PUBMED   34389433
  REMARK    GeneRIF: The novel long noncoding RNA AU021063, induced by
            IL-6/Arid5a signaling, exacerbates breast cancer invasion and
            metastasis by stabilizing Trib3 and activating the Mek/Erk pathway.
REFERENCE   5  (residues 1 to 532)
  AUTHORS   Chalise JP, Hashimoto S, Parajuli G, Kang S, Singh SK, Gemechu Y,
            Metwally H, Nyati KK, Dubey PK, Zaman MM, Nagahama Y, Hamza H,
            Masuda K and Kishimoto T.
  TITLE     Feedback regulation of Arid5a and Ppar-gamma2 maintains adipose
            tissue homeostasis
  JOURNAL   Proc Natl Acad Sci U S A 116 (30), 15128-15133 (2019)
   PUBMED   31289228
  REMARK    GeneRIF: Feedback regulation of Arid5a and Ppar-gamma2 maintains
            adipose tissue homeostasis.
REFERENCE   6  (residues 1 to 532)
  AUTHORS   Zaman MM, Masuda K, Nyati KK, Dubey PK, Ripley B, Wang K, Chalise
            JP, Higa M, Hanieh H and Kishimoto T.
  TITLE     Arid5a exacerbates IFN-gamma-mediated septic shock by stabilizing
            T-bet mRNA
  JOURNAL   Proc Natl Acad Sci U S A 113 (41), 11543-11548 (2016)
   PUBMED   27671645
  REMARK    GeneRIF: Arid5a deficiency resulted in decreased levels of
            IFN-gamma under Th1 cell conditions, in which T-box expressed in T
            cells (T-bet) mRNA expression was inhibited.
REFERENCE   7  (residues 1 to 532)
  AUTHORS   Masuda K, Ripley B, Nyati KK, Dubey PK, Zaman MM, Hanieh H, Higa M,
            Yamashita K, Standley DM, Mashima T, Katahira M, Okamoto T,
            Matsuura Y, Takeuchi O and Kishimoto T.
  TITLE     Arid5a regulates naive CD4+ T cell fate through selective
            stabilization of Stat3 mRNA
  JOURNAL   J Exp Med 213 (4), 605-619 (2016)
   PUBMED   27022145
  REMARK    GeneRIF: T cell-intrinsic role of Arid5a on fate decisions of naive
            CD4(+)T cells through selective stabilization of Stat3 mRNA.
REFERENCE   8  (residues 1 to 532)
  AUTHORS   Masuda K, Ripley B, Nishimura R, Mino T, Takeuchi O, Shioi G,
            Kiyonari H and Kishimoto T.
  TITLE     Arid5a controls IL-6 mRNA stability, which contributes to elevation
            of IL-6 level in vivo
  JOURNAL   Proc Natl Acad Sci U S A 110 (23), 9409-9414 (2013)
   PUBMED   23676272
  REMARK    GeneRIF: Arid5a controls IL-6 mRNA stability, which contributes to
            elevation of IL-6 level in vivo.
REFERENCE   9  (residues 1 to 532)
  AUTHORS   Amano K, Hata K, Muramatsu S, Wakabayashi M, Takigawa Y, Ono K,
            Nakanishi M, Takashima R, Kogo M, Matsuda A, Nishimura R and Yoneda
            T.
  TITLE     Arid5a cooperates with Sox9 to stimulate chondrocyte-specific
            transcription
  JOURNAL   Mol Biol Cell 22 (8), 1300-1311 (2011)
   PUBMED   21346191
  REMARK    GeneRIF: AT-rich interactive domain-containing protein 5a (Arid5a)
            cooperates with Sox9 to stimulate chondrocyte-specific
            transcription.
REFERENCE   10 (residues 1 to 532)
  AUTHORS   Wilsker D, Probst L, Wain HM, Maltais L, Tucker PW and Moran E.
  TITLE     Nomenclature of the ARID family of DNA-binding proteins
  JOURNAL   Genomics 86 (2), 242-251 (2005)
   PUBMED   15922553
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY196834.1, AK085015.1 and AK029237.1.
            
            On Jun 9, 2003 this sequence version replaced NP_666108.1.
            
            Transcript Variant: This variant (3) lacks two alternate in-frame
            exons in the 5' coding region, compared to variant 1. This results
            in a shorter protein (isoform 3), compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029237.1, AK085015.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..532
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 15.2 cM"
     Protein         1..532
                     /product="AT-rich interactive domain-containing protein 5A
                     isoform 3"
                     /note="AT rich interactive domain 5A (Mrf1 like);
                     modulator recognition factor I; AT-rich interactive
                     domain-containing protein 5A; ARID domain-containing
                     protein 5A; AT rich interactive domain 5A (MRF1-like)"
                     /calculated_mol_wt=56993
     Region          <42..80
                     /region_name="ARID"
                     /note="ARID/BRIGHT DNA binding domain family; cl28902"
                     /db_xref="CDD:355778"
     CDS             1..532
                     /gene="Arid5a"
                     /gene_synonym="D430024K22Rik; Mrf1"
                     /coded_by="NM_145996.4:101..1699"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS14876.1"
                     /db_xref="GeneID:214855"
                     /db_xref="MGI:MGI:2443039"
ORIGIN      
        1 maappakgnt eqseegdlpq lpvspkpdde qsrsqsptql qvtgrrlwkn vydelggspg
       61 stsaatctrr hyerlvlpyv rhlkgeddkp lpptkprkqy kmakelrgdd gtteklkkak
      121 dseerrveqt tpgktksdat gqtqlpcqgs srdsteqlgp vsgpsppltg asscpeaykr
      181 llssfyckga hgimsplakk kllaqvskae alqcqeegcr hgarspnkdi qdspqnlrgp
      241 aensehqltp reglqapggs trmeaqvgpc ptapmfsgcf hayptevlkp vsqhprdffs
      301 glkdrvllgp pgkeegpttk eshlvwggda nhpsafhkgs trkrsfypkp kacwvspmak
      361 vpterpgaps phpsspglgs krgleeegfa hggkklravs pflkevdske tggkpaapgl
      421 avscllgptp gptppeayrg tmlrcplnft gsadplkgqa slpfsplvip afpahllatt
      481 gsspmaaslm hfpptpydav lrnrlgpass awhmppvtty aaphffhlnt kl
//
LOCUS       NP_001263340            2271 aa            linear   ROD 09-OCT-2023
DEFINITION  fibronectin isoform e precursor [Mus musculus].
ACCESSION   NP_001263340
VERSION     NP_001263340.1
DBSOURCE    REFSEQ: accession NM_001276411.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 2271)
  AUTHORS   Huo X, Ma S, Wang C, Song L, Yao B, Zhu S, Li P, Wang L, Wu Z and
            Wang K.
  TITLE     Unravelling the role of immune cells and FN1 in the recurrence and
            therapeutic process of skull base chordoma
  JOURNAL   Clin Transl Med 13 (10), e1429 (2023)
   PUBMED   37784253
  REMARK    GeneRIF: Unravelling the role of immune cells and FN1 in the
            recurrence and therapeutic process of skull base chordoma.
REFERENCE   2  (residues 1 to 2271)
  AUTHORS   Whisler J, Shahreza S, Schlegelmilch K, Ege N, Javanmardi Y,
            Malandrino A, Agrawal A, Fantin A, Serwinski B, Azizgolshani H,
            Park C, Shone V, Demuren OO, Del Rosario A, Butty VL, Holroyd N,
            Domart MC, Hooper S, Szita N, Boyer LA, Walker-Samuel S, Djordjevic
            B, Sheridan GK, Collinson L, Calvo F, Ruhrberg C, Sahai E, Kamm R
            and Moeendarbary E.
  TITLE     Emergent mechanical control of vascular morphogenesis
  JOURNAL   Sci Adv 9 (32), eadg9781 (2023)
   PUBMED   37566656
REFERENCE   3  (residues 1 to 2271)
  AUTHORS   Jena SK, Das S, Chakraborty S and Ain R.
  TITLE     Molecular determinants of epithelial mesenchymal transition in
            mouse placenta and trophoblast stem cell
  JOURNAL   Sci Rep 13 (1), 10978 (2023)
   PUBMED   37414855
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 2271)
  AUTHORS   Hiver S, Shimizu-Mizuno N, Ikawa Y, Kajikawa E, Sai X, Nishimura H,
            Takaoka K, Nishimura O, Kuraku S, Tanaka S and Hamada H.
  TITLE     Gse1, a component of the CoREST complex, is required for placenta
            development in the mouse
  JOURNAL   Dev Biol 498, 97-105 (2023)
   PUBMED   37019373
REFERENCE   5  (residues 1 to 2271)
  AUTHORS   Ozguldez HO, Govindasamy N, Fan R, Long H, Mildner K, Zeuschner D,
            Trappmann B, Ranga A and Bedzhov I.
  TITLE     Polarity inversion reorganizes the stem cell compartment of the
            trophoblast lineage
  JOURNAL   Cell Rep 42 (4), 112313 (2023)
   PUBMED   36989113
REFERENCE   6  (residues 1 to 2271)
  AUTHORS   Saga Y, Yagi T, Ikawa Y, Sakakura T and Aizawa S.
  TITLE     Mice develop normally without tenascin
  JOURNAL   Genes Dev 6 (10), 1821-1831 (1992)
   PUBMED   1383086
REFERENCE   7  (residues 1 to 2271)
  AUTHORS   Khandjian EW, Salomon C, Leonard N, Tremblay S and Turler H.
  TITLE     Fibronectin gene expression in proliferating, quiescent, and
            SV40-infected mouse kidney cells
  JOURNAL   Exp Cell Res 202 (2), 464-470 (1992)
   PUBMED   1327855
REFERENCE   8  (residues 1 to 2271)
  AUTHORS   Vidal SM, Epstein DJ, Malo D, Weith A, Vekemans M and Gros P.
  TITLE     Identification and mapping of six microdissected genomic DNA probes
            to the proximal region of mouse chromosome 1
  JOURNAL   Genomics 14 (1), 32-37 (1992)
   PUBMED   1358796
REFERENCE   9  (residues 1 to 2271)
  AUTHORS   Malo D, Schurr E, Epstein DJ, Vekemans M, Skamene E and Gros P.
  TITLE     The host resistance locus Bcg is tightly linked to a group of
            cytoskeleton-associated protein genes that include villin and
            desmin
  JOURNAL   Genomics 10 (2), 356-364 (1991)
   PUBMED   1676979
REFERENCE   10 (residues 1 to 2271)
  AUTHORS   Wartiovaara,J., Leivo,I. and Vaheri,A.
  TITLE     Expression of the cell surface-associated glycoprotein,
            fibronectin, in the early mouse embryo
  JOURNAL   Dev Biol 69 (1), 247-257 (1979)
   PUBMED   376373
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ098561.1, BC138421.1, AK147663.1 and AC124821.5.
            
            Transcript Variant: This variant (5) lacks two in-frame exons and
            uses an alternate in-frame splice site in the coding region,
            compared to variant 1. The encoded isoform (e) is shorter than
            isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147663.1, BC138421.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2271
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 36.05 cM"
     Protein         1..2271
                     /product="fibronectin isoform e precursor"
                     /calculated_mol_wt=247519
     sig_peptide     1..27
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=2797
     Region          53..90
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain, approximately 40 residue
                     long with two conserved disulfide bridges. FN1 is one of
                     three types of internal repeats which combine to form
                     larger domains within fibronectin. Fibronectin, a plasma
                     protein that binds cell surfaces...; cd00061"
                     /db_xref="CDD:238018"
     Region          98..141
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          142..185
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          187..231
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          232..271
                     /region_name="fn1"
                     /note="Fibronectin type I domain; pfam00039"
                     /db_xref="CDD:425437"
     Region          308..347
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          353..401
                     /region_name="FN2"
                     /note="Fibronectin type 2 domain; smart00059"
                     /db_xref="CDD:128373"
     Site            order(364,366,371,385,392,398,400)
                     /site_type="active"
                     /note="putative gelatin-binding site [active]"
                     /db_xref="CDD:238019"
     Region          413..461
                     /region_name="FN2"
                     /note="Fibronectin type 2 domain; smart00059"
                     /db_xref="CDD:128373"
     Site            order(424,426,431,445,452,458,460)
                     /site_type="active"
                     /note="putative gelatin-binding site [active]"
                     /db_xref="CDD:238019"
     Region          470..513
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          518..560
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          561..604
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          619..688
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Region          726..797
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(797..798,800..801)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Site            order(810,871,886)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Region          811..882
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(887..888,890..891)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          907..987
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(984..985,987..988)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          997..1075
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(1073..1074,1076..1077)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1091..1158
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Region          1174..1257
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(1254..1255,1257..1258)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1267..1348
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Region          1358..1438
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Region          1450..1529
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(1525..1526,1528..1529)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1542..1622
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(1619..1620,1622..1623)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1632..1712
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(1709..1710,1712..1713)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1724..1803
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(1800..1801,1803..1804)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1813..1893
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Region          2004..2059
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Region          2090..2134
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          2135..2176
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          2178..2217
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain, approximately 40 residue
                     long with two conserved disulfide bridges. FN1 is one of
                     three types of internal repeats which combine to form
                     larger domains within fibronectin. Fibronectin, a plasma
                     protein that binds cell surfaces...; cd00061"
                     /db_xref="CDD:238018"
     CDS             1..2271
                     /gene="Fn1"
                     /gene_synonym="E330027I09; Fn; Fn-1"
                     /coded_by="NM_001276411.1:253..7068"
                     /note="isoform e precursor is encoded by transcript
                     variant 5"
                     /db_xref="CCDS:CCDS78608.1"
                     /db_xref="GeneID:14268"
                     /db_xref="MGI:MGI:95566"
ORIGIN      
        1 mlrgpgpgrl lllavlclgt svrcteagks krqaqqivqp qspvavsqsk pgcfdngkhy
       61 qinqqwerty lgnalvctcy ggsrgfnces kpepeetcfd kytgntykvg dtyerpkdsm
      121 iwdctcigag rgrisctian rcheggqsyk igdkwrrphe tggymleclc lgngkgewtc
      181 kpiaekcfdh aagtsyvvge twekpyqgwm mvdctclgeg ngritctsrn rcndqdtrts
      241 yrigdtwskk dnrgnllqcv ctgngrgewk cerhalqsas agsgsftdvr taiyqpqthp
      301 qpapyghcvt dsgvvysvgm qwlksqgnkq mlctclgngv scqetavtqt yggnsngepc
      361 vlpftyngrt fyscttegrq dghlwcstts nyeqdqkysf ctdhavlvqt rggnsngalc
      421 hfpflynnrn ytdctsegrr dnmkwcgttq nydadqkfgf cpmaaheeic ttnegvmyri
      481 gdqwdkqhdl ghmmrctcvg ngrgewacip ysqlrdqciv dditynvndt fhkrheeghm
      541 lnctcfgqgr grwkcdpidq cqdsetrtfy qigdswekfv hgvryqcycy grgigewhcq
      601 plqtypgttg pvqviitetp sqpnshpiqw napepshitk yilrwrpkts tgrwkeatip
      661 ghlnsytikg ltpgviyegq lisiqqyghr evtrfdftts astpvtsntv tgetapyspv
      721 vatsesvtei tassfvvswv sasdtvsgfr veyelseegd epqyldlpst atsvnipdll
      781 pgrkyivnvy qiseegkqsl ilstsqttap dappdptvdq vddtsivvrw srpqapitgy
      841 rivyspsveg sstelnlpet ansvtlsdlq pgvqynitiy aveenqestp vfiqqettgt
      901 prsdnvpppt dlqfveltdv kvtimwtppd svvsgyrvev lpvslpgehg qrlpvnrntf
      961 aeitglspgv tylfkvfavh qgresnplta qqttkldapt nlqfvnetdr tvlvtwtppr
     1021 ariagyrlta gltrggqpkq ynvgplasky plrnlqpgse ytvtlvavkg nqqspkatgv
     1081 fttlqplrsi ppyntevtet tivitwtpap rigfklgvrp sqggeaprev tsdsgsivvs
     1141 gltpgveyty tiqvlrdgqe rdapivnrvv tplspptnlh leanpdtgvl tvswersttp
     1201 ditgyrittt ptngqqgtsl eevvhadqss ctfenlnpgl eynvsvytvk ddkesapisd
     1261 tvvpavpppt dlrftnigpd tmrvtwappp sieltnllvr yspvkneedv aelsispsdn
     1321 avvltnllpg teylvsvssv yeqhesiplr grqktgldsp tgfdssdita nsftvhwvap
     1381 rapitgyiir hhaehsvgrp rqdrvppsrn sitltnlnpg teyvvsiiav ngreesppli
     1441 gqqatvsdip rdleviastp tslliswepp avsvryyrit ygetggnspv qeftvpgsks
     1501 tatinnikpg adytitlyav tgrgdspass kpvsinykte idkpsqmqvt dvqdnsisvr
     1561 wlpstspvtg yrvtttpkng lgpsktktas pdqtemtieg lqptveyvvs vyaqnrnges
     1621 qplvqtavtt ipaptnlkfs qvtptsftaq wiapsvqltg yrvrvnpkek tgpmkeinls
     1681 pdsssvivsg lmvatkyevs vyalkdtlts rpaqgvittl envspprrar vtdatettit
     1741 iswrtkteti tgfqvdaipa ngqtpvqrsi spdvrsytit glqpgtdyki hlytlndnar
     1801 sspviidast aidapsnlrf ltttpnsllv swqaprarit gyiikyekpg spprevvprp
     1861 rpgvteatit glepgteyti yvialknnqk sepligrkkt vqktpfitnp gydtengiql
     1921 pgtthqqpsv gqqmifeehg frrttpptaa tpvrlrprpy lpnvdeevqi ghvprgdvdy
     1981 hlyphvpgln pnastgqeal sqttiswtpf qesseyiisc qpvgtdeepl qfqvpgtsts
     2041 atltgltrgv tyniivealq nqrrhkvree vvtvgnavse glnqptddsc fdpytvshya
     2101 igeewerlsd agfkltcqcl gfgsghfrcd sskwchdngv nykigekwdr qgengqrmsc
     2161 tclgngkgef kcdpheatcy ddgktyhvge qwqkeylgai csctcfggqr gwrcdncrrp
     2221 gaaepspdgt tghtynqytq rynqrtntnv ncpiecfmpl dvqadrddsr e
//
LOCUS       NP_997121                279 aa            linear   ROD 09-OCT-2023
DEFINITION  F-box only protein 27 isoform 2 [Mus musculus].
ACCESSION   NP_997121 XP_133309
VERSION     NP_997121.1
DBSOURCE    REFSEQ: accession NM_207238.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 279)
  AUTHORS   Liu D, Xing R, Zhang Q, Tian X, Qi Y, Song H, Liu Y, Yu H, Zhang X,
            Jing Q, Yan C and Han Y.
  TITLE     The CREG1-FBXO27-LAMP2 axis alleviates diabetic cardiomyopathy by
            promoting autophagy in cardiomyocytes
  JOURNAL   Exp Mol Med 55 (9), 2025-2038 (2023)
   PUBMED   37658156
  REMARK    GeneRIF: The CREG1-FBXO27-LAMP2 axis alleviates diabetic
            cardiomyopathy by promoting autophagy in cardiomyocytes.
REFERENCE   2  (residues 1 to 279)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK053292.1 and BQ033399.1.
            
            On Aug 30, 2004 this sequence version replaced XP_133309.4.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and uses
            an alternate in-frame splice site in the 5' coding region compared
            to variant 1. The resulting protein (isoform 2) is shorter but has
            the same N- and C-termini compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK053292.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849389
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..279
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 16.89 cM"
     Protein         1..279
                     /product="F-box only protein 27 isoform 2"
                     /note="F-box only protein 27"
                     /calculated_mol_wt=31372
     Region          <37..70
                     /region_name="F-box_SF"
                     /note="F-box domain superfamily; cl45894"
                     /db_xref="CDD:459239"
     Region          102..274
                     /region_name="FBA"
                     /note="F-box associated region; pfam04300"
                     /db_xref="CDD:427850"
     CDS             1..279
                     /gene="Fbxo27"
                     /gene_synonym="E130008B10Rik; FBG5; Gm161"
                     /coded_by="NM_207238.3:151..990"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS21051.1"
                     /db_xref="GeneID:233040"
                     /db_xref="MGI:MGI:2685007"
ORIGIN      
        1 mgawisrtrv ptpepdpqev ldlsrlppel lllvlshvpp rtllmhcrrv crawralvdg
       61 qalwllllar dhsaagrall tlarrclppa hedtpcplgq fcalrplgrn lisnpcgqgl
      121 rkwmvrhggd gwvveknrkp vpgapsqtcf vtsfswcrkk qvvdlvekgl wpelldsggv
      181 eiavsdwwga rhdsgckyrl fvtlldahqn vidkfsavpd pieqwnndiy lqvthvfsgi
      241 rrgirfvsfe hwgqdtqfwa ghygarvtns sviirvcqs
//
LOCUS       NP_201582                776 aa            linear   ROD 09-OCT-2023
DEFINITION  lysyl oxidase homolog 2 precursor [Mus musculus].
ACCESSION   NP_201582 XP_919062
VERSION     NP_201582.2
DBSOURCE    REFSEQ: accession NM_033325.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 776)
  AUTHORS   Lu YJ, Deng YT, Ko HH, Peng HH, Lee HC, Kuo MY and Cheng SJ.
  TITLE     Lysyl oxidase-like 2 promotes stemness and enhances antitumor
            effects of gefitinib in head and neck cancer via IFIT1 and IFIT3
  JOURNAL   Cancer Sci 114 (10), 3957-3971 (2023)
   PUBMED   37496288
  REMARK    GeneRIF: Lysyl oxidase-like 2 promotes stemness and enhances
            antitumor effects of gefitinib in head and neck cancer via IFIT1
            and IFIT3.
REFERENCE   2  (residues 1 to 776)
  AUTHORS   Lu X, Xin DE, Du JK, Zou QC, Wu Q, Zhang YS, Deng W, Yue J, Fan XS,
            Zeng Y, Cheng X, Li X, Hou Z, Mohan M, Zhao TC, Lu X, Chang Z, Xu
            L, Sun Y, Zu X, Zhang Y and Chinn YE.
  TITLE     Loss of LOXL2 Promotes Uterine Hypertrophy and Tumor Progression by
            Enhancing H3K36ac-Dependent Gene Expression
  JOURNAL   Cancer Res 82 (23), 4400-4413 (2022)
   PUBMED   36197797
  REMARK    GeneRIF: Loss of LOXL2 Promotes Uterine Hypertrophy and Tumor
            Progression by Enhancing H3K36ac-Dependent Gene Expression.
REFERENCE   3  (residues 1 to 776)
  AUTHORS   Santamaria PG, Dubus P, Bustos-Tauler J, Floristan A,
            Vazquez-Naharro A, Morales S, Cano A and Portillo F.
  TITLE     Loxl2 and Loxl3 Paralogues Play Redundant Roles during Mouse
            Development
  JOURNAL   Int J Mol Sci 23 (10), 5730 (2022)
   PUBMED   35628534
  REMARK    GeneRIF: Loxl2 and Loxl3 Paralogues Play Redundant Roles during
            Mouse Development.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 776)
  AUTHORS   Wang H, Poe A, Pak L, Nandakumar K, Jandu S, Steppan J, Loser R and
            Santhanam L.
  TITLE     An in situ activity assay for lysyl oxidases
  JOURNAL   Commun Biol 4 (1), 840 (2021)
   PUBMED   34226627
  REMARK    GeneRIF: An in situ activity assay for lysyl oxidases.
            Erratum:[Commun Biol. 2021 Sep 16;4(1):1110. PMID: 34531545]
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 776)
  AUTHORS   Matsuo A, Tanida R, Yanagi S, Tsubouchi H, Miura A, Shigekusa T,
            Matsumoto N and Nakazato M.
  TITLE     Significance of nuclear LOXL2 inhibition in fibroblasts and
            myofibroblasts in the fibrotic process of acute respiratory
            distress syndrome
  JOURNAL   Eur J Pharmacol 892, 173754 (2021)
   PUBMED   33248114
  REMARK    GeneRIF: Significance of nuclear LOXL2 inhibition in fibroblasts
            and myofibroblasts in the fibrotic process of acute respiratory
            distress syndrome.
REFERENCE   6  (residues 1 to 776)
  AUTHORS   Pischon N, Maki JM, Weisshaupt P, Heng N, Palamakumbura AH,
            N'Guessan P, Ding A, Radlanski R, Renz H, Bronckers TA, Myllyharju
            J, Kielbassa AM, Kleber BM, Bernimoulin JP and Trackman PC.
  TITLE     Lysyl oxidase (lox) gene deficiency affects osteoblastic phenotype
  JOURNAL   Calcif Tissue Int 85 (2), 119-126 (2009)
   PUBMED   19458888
REFERENCE   7  (residues 1 to 776)
  AUTHORS   Hoffman BG, Zavaglia B, Witzsche J, Ruiz de Algara T, Beach M,
            Hoodless PA, Jones SJ, Marra MA and Helgason CD.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   8  (residues 1 to 776)
  AUTHORS   Atsawasuwan P, Mochida Y, Parisuthiman D and Yamauchi M.
  TITLE     Expression of lysyl oxidase isoforms in MC3T3-E1 osteoblastic cells
  JOURNAL   Biochem Biophys Res Commun 327 (4), 1042-1046 (2005)
   PUBMED   15652501
  REMARK    GeneRIF: LoxL2 is not expressed in MC3T3-E1 cells.
REFERENCE   9  (residues 1 to 776)
  AUTHORS   Jourdan-Le Saux C, Le Saux O, Gleyzal C, Sommer P and Csiszar K.
  TITLE     The mouse lysyl oxidase-like 2 gene (mLOXL2) maps to chromosome 14
            and is highly expressed in skin, lung and thymus
  JOURNAL   Matrix Biol 19 (2), 179-183 (2000)
   PUBMED   10842102
REFERENCE   10 (residues 1 to 776)
  AUTHORS   Jang W, Hua A, Spilson SV, Miller W, Roe BA and Meisler MH.
  TITLE     Comparative sequence of human and mouse BAC clones from the mnd2
            region of chromosome 2p13
  JOURNAL   Genome Res 9 (1), 53-61 (1999)
   PUBMED   9927484
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC160639.2, AK045019.1, AK159386.1 and AA437829.1.
            
            On Mar 24, 2009 this sequence version replaced NP_201582.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK045019.1, SRR17253012.797844.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..776
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 36.06 cM"
     Protein         1..776
                     /product="lysyl oxidase homolog 2 precursor"
                     /EC_number="1.4.3.13"
                     /note="lysyl oxidase homolog 2; lysyl oxidase-like protein
                     2"
                     /calculated_mol_wt=84433
     sig_peptide     1..25
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=2588
     Region          61..162
                     /region_name="SR"
                     /note="Scavenger receptor Cys-rich; smart00202"
                     /db_xref="CDD:214555"
     Region          204..304
                     /region_name="SR"
                     /note="Scavenger receptor Cys-rich; smart00202"
                     /db_xref="CDD:214555"
     Site            267
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58022.2)"
     Site            291
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58022.2)"
     Region          329..428
                     /region_name="SR"
                     /note="Scavenger receptor Cys-rich; smart00202"
                     /db_xref="CDD:214555"
     Region          438..546
                     /region_name="SR"
                     /note="Scavenger receptor Cys-rich; smart00202"
                     /db_xref="CDD:214555"
     Site            458
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58022.2)"
     Region          550..753
                     /region_name="Lysyl-oxidase like. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P58022.2)"
     Region          550..748
                     /region_name="Lysyl_oxidase"
                     /note="Lysyl oxidase; pfam01186"
                     /db_xref="CDD:426108"
     Site            646
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58022.2)"
     CDS             1..776
                     /gene="Loxl2"
                     /gene_synonym="1110004B06Rik; 4930526G11Rik;
                     9430067E15Rik"
                     /coded_by="NM_033325.2:135..2465"
                     /db_xref="CCDS:CCDS27241.1"
                     /db_xref="GeneID:94352"
                     /db_xref="MGI:MGI:2137913"
ORIGIN      
        1 melhfgscls gclallvllp slslaqyegw pyqlqypeyf qqpapehhqr qvpsdvvkiq
       61 vrlagqkrkh negrvevyye gqwgtvcddd fsihaahvvc rqvgyveaks waasssygpg
      121 egpiwldniy ctgkestlas cssngwgvtd ckhtedvgvv csekripgfk fdnslinqie
      181 slniqvedir irpilsafrh rkpvtegyve vkegkawkqi cnkhwtakns hvvcgmfgfp
      241 aektynpkay ktfasrrklr ywkfsmnctg teahissckl gpsvtrdpvk natcengqpa
      301 vvscvpsqif spdgpsrfrk aykpeqplvr lrggaqvgeg rvevlkngew gticddkwdl
      361 vsasvvcrel gfgtakeait gsrlgqgigp ihlnevqctg teksiidckf ntesqgcnhe
      421 edagvrcnip imgfqkkvrl nggrnpyegr vevlterngs lvwgtvcgqn wgiveamvvc
      481 rqlglgfasn afqetwywhg nifannvvms gvkcsgtels lahcrhdeev acpeggvrfg
      541 agvacsetap dlvlnaeivq qtayledrpm sllqcameen clsasavhtd ptrghrrllr
      601 fssqihnngq sdfrpkngrh awiwhdchrh yhsmevftyy dllslngtkv aeghkasfcl
      661 edtecegdiq ksyecanfge qgitmgcwdm yrhdidcqwi ditdvppgdy lfqvvinpny
      721 evpesdfsnn imkcrsrydg yriwmynchv ggafseeteq kfehfsglln nqlsvq
//
LOCUS       NP_001349237             494 aa            linear   ROD 09-OCT-2023
DEFINITION  CUGBP Elav-like family member 4 isoform 30 [Mus musculus].
ACCESSION   NP_001349237 XP_017173283
VERSION     NP_001349237.1
DBSOURCE    REFSEQ: accession NM_001362308.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 494)
  AUTHORS   Salamon I, Park Y, Miskic T, Kopic J, Matteson P, Page NF, Roque A,
            McAuliffe GW, Favate J, Garcia-Forn M, Shah P, Judas M, Millonig
            JH, Kostovic I, De Rubeis S, Hart RP, Krsnik Z and Rasin MR.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    GeneRIF: Celf4 controls mRNA translation underlying synaptic
            development in the prenatal mammalian neocortex.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 494)
  AUTHORS   Shen Y, Zhang C, Xiao K, Liu D and Xie G.
  TITLE     CELF4 regulates spine formation and depression-like behaviors of
            mice
  JOURNAL   Biochem Biophys Res Commun 605, 39-44 (2022)
   PUBMED   35306363
  REMARK    GeneRIF: CELF4 regulates spine formation and depression-like
            behaviors of mice.
REFERENCE   3  (residues 1 to 494)
  AUTHORS   Moreau MX, Saillour Y, Cwetsch AW, Pierani A and Causeret F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   4  (residues 1 to 494)
  AUTHORS   Li C, Li X, Bi Z, Sugino K, Wang G, Zhu T and Liu Z.
  TITLE     Comprehensive transcriptome analysis of cochlear spiral ganglion
            neurons at multiple ages
  JOURNAL   Elife 9, e50491 (2020)
   PUBMED   31913118
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 494)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 494)
  AUTHORS   Ladd AN, Taffet G, Hartley C, Kearney DL and Cooper TA.
  TITLE     Cardiac tissue-specific repression of CELF activity disrupts
            alternative splicing and causes cardiomyopathy
  JOURNAL   Mol Cell Biol 25 (14), 6267-6278 (2005)
   PUBMED   15988035
  REMARK    GeneRIF: CELF protein activity is required for normal alternative
            splicing in the heart in vivo and normal CELF-mediated alternative
            splicing regulation is in turn required for normal cardiac
            function.
REFERENCE   7  (residues 1 to 494)
  AUTHORS   Meins M, Schlickum S, Wilhelm C, Missbach J, Yadav S, Glaser B,
            Grzmil M, Burfeind P and Laccone F.
  TITLE     Identification and characterization of murine Brunol4, a new member
            of the elav/bruno family
  JOURNAL   Cytogenet Genome Res 97 (3-4), 254-260 (2002)
   PUBMED   12438720
  REMARK    GeneRIF: cloning and characterization
REFERENCE   8  (residues 1 to 494)
  AUTHORS   Ladd AN, Charlet N and Cooper TA.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   9  (residues 1 to 494)
  AUTHORS   Good PJ, Chen Q, Warner SJ and Herring DC.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
REFERENCE   10 (residues 1 to 494)
  AUTHORS   Yulug IG, Egan SE, See CG and Fisher EM.
  TITLE     Mapping GRB2, a signal transduction gene in the human and the mouse
  JOURNAL   Genomics 22 (2), 313-318 (1994)
   PUBMED   7806216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121094.8 and AC144938.3.
            
            On Apr 12, 2018 this sequence version replaced XP_017173283.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.170366.1,
                                           SRR1660819.44819.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 13.92 cM"
     Protein         1..494
                     /product="CUGBP Elav-like family member 4 isoform 30"
                     /note="CUG-BP- and ETR-3-like factor 4; bruno-like protein
                     4; RNA-binding protein BRUNOL-4; bruno-like 4, RNA binding
                     protein"
                     /calculated_mol_wt=52771
     Region          49..135
                     /region_name="RRM1_CELF3_4_5_6"
                     /note="RNA recognition motif 1 (RRM1) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12632"
                     /db_xref="CDD:410041"
     Site            order(55,57,59..60,63,82,84,86,95..97,99,129,131)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410041"
     Region          140..220
                     /region_name="RRM2_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12635"
                     /db_xref="CDD:410043"
     Site            order(142,144,146..147,150,169,171,173,181..183,185,215,
                     217)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410043"
     Region          405..483
                     /region_name="RRM3_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12639"
                     /db_xref="CDD:241083"
     CDS             1..494
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /coded_by="NM_001362308.1:531..2015"
                     /note="isoform 30 is encoded by transcript variant 34"
                     /db_xref="GeneID:108013"
                     /db_xref="MGI:MGI:1932407"
ORIGIN      
        1 myikmatlan gqadnaslst nglgsspgsa ghmnglshsp gnpstipmkd hdaiklfigq
       61 iprnldekdl kplfeefgki yeltvlkdrf tgmhkgcafl tyceresalk aqsalheqkt
      121 lpgmnrpiqv kpadsesrgd rklfvgmlnk qqseddvrrl feafgnieec tilrgpdgns
      181 kgcafvkyss haeaqaaina lhgsqtmpga ssslvvkfad tdkertmrrm qqmagqmgmf
      241 npmaipfgay gayaqalmqq qaalmasvaq ggylnpmaaf aaaqmqqmaa lnmnglaaap
      301 mtptsggstp pgitapavps ipspigvngf tglppqangq paaeavfang ihpypaqspt
      361 aadplqqaya gvqqyagpay paaygqisqa fpqpppmipq qqregpegcn lliyhlpqef
      421 gdaelmqmfl pfgnvisskv fvdratnqsk cfgfvsfdnp asaqtaiqam ngfqigmkrl
      481 kvqlkrpkda nrpy
//
LOCUS       NP_001074812             481 aa            linear   ROD 09-OCT-2023
DEFINITION  guanine nucleotide exchange factor C9orf72 homolog isoform 1 [Mus
            musculus].
ACCESSION   NP_001074812 XP_901191
VERSION     NP_001074812.1
DBSOURCE    REFSEQ: accession NM_001081343.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 481)
  AUTHORS   Hendricks E, Quihuis AM, Hung ST, Chang J, Dorjsuren N, Der B,
            Staats KA, Shi Y, Sta Maria NS, Jacobs RE and Ichida JK.
  TITLE     The C9ORF72 repeat expansion alters neurodevelopment
  JOURNAL   Cell Rep 42 (8), 112983 (2023)
   PUBMED   37590144
  REMARK    GeneRIF: The C9ORF72 repeat expansion alters neurodevelopment.
REFERENCE   2  (residues 1 to 481)
  AUTHORS   Pang W and Hu F.
  TITLE     C9ORF72 suppresses JAK-STAT mediated inflammation
  JOURNAL   iScience 26 (5), 106579 (2023)
   PUBMED   37250330
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 481)
  AUTHORS   He L, Liang J, Chen C, Chen J, Shen Y, Sun S and Li L.
  TITLE     C9orf72 functions in the nucleus to regulate DNA damage repair
  JOURNAL   Cell Death Differ 30 (3), 716-730 (2023)
   PUBMED   36220889
  REMARK    GeneRIF: C9orf72 functions in the nucleus to regulate DNA damage
            repair.
REFERENCE   4  (residues 1 to 481)
  AUTHORS   Shu X, Wei C, Tu WY, Zhong K, Qi S, Wang A, Bai L, Zhang SX, Luo B,
            Xu ZZ, Zhang K and Shen C.
  TITLE     Negative regulation of TREM2-mediated C9orf72 poly-GA clearance by
            the NLRP3 inflammasome
  JOURNAL   Cell Rep 42 (2), 112133 (2023)
   PUBMED   36800288
  REMARK    GeneRIF: Negative regulation of TREM2-mediated C9orf72 poly-GA
            clearance by the NLRP3 inflammasome.
REFERENCE   5  (residues 1 to 481)
  AUTHORS   Liu Y, Xing H, Ernst AF, Liu C, Maugee C, Yokoi F, Lakshmana M and
            Li Y.
  TITLE     Hyperactivity of Purkinje cell and motor deficits in C9orf72
            knockout mice
  JOURNAL   Mol Cell Neurosci 121, 103756 (2022)
   PUBMED   35843530
  REMARK    GeneRIF: Hyperactivity of Purkinje cell and motor deficits in
            C9orf72 knockout mice.
REFERENCE   6  (residues 1 to 481)
  AUTHORS   Chew J, Gendron TF, Prudencio M, Sasaguri H, Zhang YJ,
            Castanedes-Casey M, Lee CW, Jansen-West K, Kurti A, Murray ME,
            Bieniek KF, Bauer PO, Whitelaw EC, Rousseau L, Stankowski JN,
            Stetler C, Daughrity LM, Perkerson EA, Desaro P, Johnston A,
            Overstreet K, Edbauer D, Rademakers R, Boylan KB, Dickson DW, Fryer
            JD and Petrucelli L.
  TITLE     Neurodegeneration. C9ORF72 repeat expansions in mice cause TDP-43
            pathology, neuronal loss, and behavioral deficits
  JOURNAL   Science 348 (6239), 1151-1154 (2015)
   PUBMED   25977373
REFERENCE   7  (residues 1 to 481)
  AUTHORS   Farg MA, Sundaramoorthy V, Sultana JM, Yang S, Atkinson RA, Levina
            V, Halloran MA, Gleeson PA, Blair IP, Soo KY, King AE and Atkin JD.
  TITLE     C9ORF72, implicated in amytrophic lateral sclerosis and
            frontotemporal dementia, regulates endosomal trafficking
  JOURNAL   Hum Mol Genet 23 (13), 3579-3595 (2014)
   PUBMED   24549040
  REMARK    Erratum:[Hum Mol Genet. 2017 Oct 15;26(20):4093-4094. PMID:
            28973528]
REFERENCE   8  (residues 1 to 481)
  AUTHORS   Suzuki N, Maroof AM, Merkle FT, Koszka K, Intoh A, Armstrong I,
            Moccia R, Davis-Dusenbery BN and Eggan K.
  TITLE     The mouse C9ORF72 ortholog is enriched in neurons known to
            degenerate in ALS and FTD
  JOURNAL   Nat Neurosci 16 (12), 1725-1727 (2013)
   PUBMED   24185425
REFERENCE   9  (residues 1 to 481)
  AUTHORS   Lagier-Tourenne C, Baughn M, Rigo F, Sun S, Liu P, Li HR, Jiang J,
            Watt AT, Chun S, Katz M, Qiu J, Sun Y, Ling SC, Zhu Q, Polymenidou
            M, Drenner K, Artates JW, McAlonis-Downes M, Markmiller S, Hutt KR,
            Pizzo DP, Cady J, Harms MB, Baloh RH, Vandenberg SR, Yeo GW, Fu XD,
            Bennett CF, Cleveland DW and Ravits J.
  TITLE     Targeted degradation of sense and antisense C9orf72 RNA foci as
            therapy for ALS and frontotemporal degeneration
  JOURNAL   Proc Natl Acad Sci U S A 110 (47), E4530-E4539 (2013)
   PUBMED   24170860
REFERENCE   10 (residues 1 to 481)
  AUTHORS   Panda SK, Wefers B, Ortiz O, Floss T, Schmid B, Haass C, Wurst W
            and Kuhn R.
  TITLE     Highly efficient targeted mutagenesis in mice using TALENs
  JOURNAL   Genetics 195 (3), 703-713 (2013)
   PUBMED   23979585
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL831776.3.
            
            On Feb 6, 2007 this sequence version replaced XP_901191.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154817.1, AK167354.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..481
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 17.13 cM"
     Protein         1..481
                     /product="guanine nucleotide exchange factor C9orf72
                     homolog isoform 1"
                     /note="protein C9orf72 homolog; guanine nucleotide
                     exchange C9orf72 homolog; guanine nucleotide exchange
                     factor C9orf72 homolog"
                     /calculated_mol_wt=54147
     Region          61..324
                     /region_name="C9orf72-like"
                     /note="C9orf72-like protein family; pfam15019"
                     /db_xref="CDD:434396"
     Region          461..481
                     /region_name="Required for the homodimerization of the
                     C9orf72-SMCR8 complex.
                     /evidence=ECO:0000250|UniProtKB:Q96LT7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6DFW0.2)"
     CDS             1..481
                     /gene="C9orf72"
                     /gene_synonym="3110043O21Rik; Dennd9"
                     /coded_by="NM_001081343.2:109..1554"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS38708.1"
                     /db_xref="GeneID:73205"
                     /db_xref="MGI:MGI:1920455"
ORIGIN      
        1 msticpppsp avakteials gespllaatf aywdnilgpr vrhiwapktd qvllsdgeit
       61 flanhtlnge ilrnaesgai dvkffvlsek gviivslifd gnwngdrsty glsiilpqte
      121 lsfylplhrv cvdrlthiir kgriwmhker qenvqkivle gtermedqgq siipmltgev
      181 ipvmellasm kshsvpedid iadtvlnddd igdschegfl lnaisshlqt cgcsvvvgss
      241 aekvnkivrt lclfltpaer kcsrlceaes sfkyesglfv qgllkdatgs fvlpfrqvmy
      301 apyptthidv dvntvkqmpp chehiynqrr ymrseltafw ratseedmaq dtiiytdesf
      361 tpdlnifqdv lhrdtlvkaf ldqvfhlkpg lslrstflaq fllilhrkal tlikyieddt
      421 qkgkkpfksl rnlkidldlt aegdlniima laekikpglh sfifgrpfyt svqerdvlmt
      481 f
//
LOCUS       NP_001167545             456 aa            linear   ROD 09-OCT-2023
DEFINITION  CUGBP Elav-like family member 4 isoform 51 [Mus musculus].
ACCESSION   NP_001167545
VERSION     NP_001167545.1
DBSOURCE    REFSEQ: accession NM_001174074.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 456)
  AUTHORS   Salamon I, Park Y, Miskic T, Kopic J, Matteson P, Page NF, Roque A,
            McAuliffe GW, Favate J, Garcia-Forn M, Shah P, Judas M, Millonig
            JH, Kostovic I, De Rubeis S, Hart RP, Krsnik Z and Rasin MR.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    GeneRIF: Celf4 controls mRNA translation underlying synaptic
            development in the prenatal mammalian neocortex.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 456)
  AUTHORS   Shen Y, Zhang C, Xiao K, Liu D and Xie G.
  TITLE     CELF4 regulates spine formation and depression-like behaviors of
            mice
  JOURNAL   Biochem Biophys Res Commun 605, 39-44 (2022)
   PUBMED   35306363
  REMARK    GeneRIF: CELF4 regulates spine formation and depression-like
            behaviors of mice.
REFERENCE   3  (residues 1 to 456)
  AUTHORS   Moreau MX, Saillour Y, Cwetsch AW, Pierani A and Causeret F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   4  (residues 1 to 456)
  AUTHORS   Li C, Li X, Bi Z, Sugino K, Wang G, Zhu T and Liu Z.
  TITLE     Comprehensive transcriptome analysis of cochlear spiral ganglion
            neurons at multiple ages
  JOURNAL   Elife 9, e50491 (2020)
   PUBMED   31913118
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 456)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 456)
  AUTHORS   Ladd AN, Taffet G, Hartley C, Kearney DL and Cooper TA.
  TITLE     Cardiac tissue-specific repression of CELF activity disrupts
            alternative splicing and causes cardiomyopathy
  JOURNAL   Mol Cell Biol 25 (14), 6267-6278 (2005)
   PUBMED   15988035
  REMARK    GeneRIF: CELF protein activity is required for normal alternative
            splicing in the heart in vivo and normal CELF-mediated alternative
            splicing regulation is in turn required for normal cardiac
            function.
REFERENCE   7  (residues 1 to 456)
  AUTHORS   Meins M, Schlickum S, Wilhelm C, Missbach J, Yadav S, Glaser B,
            Grzmil M, Burfeind P and Laccone F.
  TITLE     Identification and characterization of murine Brunol4, a new member
            of the elav/bruno family
  JOURNAL   Cytogenet Genome Res 97 (3-4), 254-260 (2002)
   PUBMED   12438720
  REMARK    GeneRIF: cloning and characterization
REFERENCE   8  (residues 1 to 456)
  AUTHORS   Ladd AN, Charlet N and Cooper TA.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   9  (residues 1 to 456)
  AUTHORS   Good PJ, Chen Q, Warner SJ and Herring DC.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
REFERENCE   10 (residues 1 to 456)
  AUTHORS   Yulug IG, Egan SE, See CG and Fisher EM.
  TITLE     Mapping GRB2, a signal transduction gene in the human and the mouse
  JOURNAL   Genomics 22 (2), 313-318 (1994)
   PUBMED   7806216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121094.8, BC052744.1, AK051458.1 and AC144938.3.
            
            Transcript Variant: This variant (6) encodes isoform (51, also
            known as F).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK051458.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..456
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 13.92 cM"
     Protein         1..456
                     /product="CUGBP Elav-like family member 4 isoform 51"
                     /note="CUG-BP- and ETR-3-like factor 4; bruno-like protein
                     4; RNA-binding protein BRUNOL-4; bruno-like 4, RNA binding
                     protein"
                     /calculated_mol_wt=48424
     Region          49..135
                     /region_name="RRM1_CELF3_4_5_6"
                     /note="RNA recognition motif 1 (RRM1) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12632"
                     /db_xref="CDD:410041"
     Site            order(55,57,59..60,63,82,84,86,95..97,99,129,131)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410041"
     Region          151..231
                     /region_name="RRM2_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12635"
                     /db_xref="CDD:410043"
     Site            order(153,155,157..158,161,180,182,184,192..194,196,226,
                     228)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410043"
     Region          <415..455
                     /region_name="RRM_SF"
                     /note="RNA recognition motif (RRM) superfamily; cl17169"
                     /db_xref="CDD:450164"
     CDS             1..456
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /coded_by="NM_001174074.2:531..1901"
                     /note="isoform 51 is encoded by transcript variant 6"
                     /db_xref="CCDS:CCDS89204.1"
                     /db_xref="GeneID:108013"
                     /db_xref="MGI:MGI:1932407"
ORIGIN      
        1 myikmatlan gqadnaslst nglgsspgsa ghmnglshsp gnpstipmkd hdaiklfigq
       61 iprnldekdl kplfeefgki yeltvlkdrf tgmhkgcafl tyceresalk aqsalheqkt
      121 lpgmnrpiqv kpadsesrgg ssclrqppsq drklfvgmln kqqseddvrr lfeafgniee
      181 ctilrgpdgn skgcafvkys shaeaqaain alhgsqtmpg assslvvkfa dtdkertmrr
      241 mqqmagqmgm fnpmaipfga ygayaqamqq qaalmasvaq ggylnpmaaf aaaqmqqmaa
      301 lnmnglaaap mtptsggstp pgitapavps ipspigvngf tglppqangq paaeavfang
      361 ihpypaqspt aadplqqaya gvqqyagpay paaygqisqa fpqpppmipq qqregfvsfd
      421 npasaqtaiq amngfqigmk rlkvqlkrpk danrpy
//
LOCUS       NP_001277945              91 aa            linear   ROD 09-OCT-2023
DEFINITION  bcl-2-like protein 11 isoform 4 [Mus musculus].
ACCESSION   NP_001277945 XP_006498681
VERSION     NP_001277945.1
DBSOURCE    REFSEQ: accession NM_001291016.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 91)
  AUTHORS   Jiang M, Wang XB and Jiang S.
  TITLE     circ_0000018 downregulation peripherally ameliorates
            neuroprotection against acute ischemic stroke through the
            miR-871/BCL2L11 axis
  JOURNAL   Mol Med Rep 28 (5) (2023)
   PUBMED   37772397
  REMARK    GeneRIF: circ_0000018 downregulation peripherally ameliorates
            neuroprotection against acute ischemic stroke through the
            miR-871/BCL2L11 axis.
REFERENCE   2  (residues 1 to 91)
  AUTHORS   Lu Y, Tang K, Wang S, Tian Z, Fan Y, Li B, Wang M, Zhao J and Xie
            J.
  TITLE     Dach1 deficiency drives alveolar epithelium apoptosis in pulmonary
            fibrosis via modulating C-Jun/Bim activity
  JOURNAL   Transl Res 257, 54-65 (2023)
   PUBMED   36754276
  REMARK    GeneRIF: Dach1 deficiency drives alveolar epithelium apoptosis in
            pulmonary fibrosis via modulating C-Jun/Bim activity.
REFERENCE   3  (residues 1 to 91)
  AUTHORS   Nguyen HV, Vandenberg CJ, Robati MR, Ng AP and Cory S.
  TITLE     MNT suppresses T cell apoptosis via BIM and is critical for T
            lymphomagenesis
  JOURNAL   Cell Death Differ 30 (4), 1018-1032 (2023)
   PUBMED   36755068
  REMARK    GeneRIF: MNT suppresses T cell apoptosis via BIM and is critical
            for T lymphomagenesis.
REFERENCE   4  (residues 1 to 91)
  AUTHORS   Chen H, Bai Y, Kobayashi M, Xiao S, Cai W, Barajas S, Chen S, Miao
            J, Meke FN, Vemula S, Ropa JP, Croop JM, Boswell HS, Wan J, Jia Y,
            Liu H, Li LS, Altman JK, Eklund EA, Ji P, Tong W, Band H, Huang DT,
            Platanias LC, Zhang ZY and Liu Y.
  TITLE     PRL2 phosphatase enhances oncogenic FLT3 signaling via
            dephosphorylation of the E3 ubiquitin ligase CBL at tyrosine 371
  JOURNAL   Blood 141 (3), 244-259 (2023)
   PUBMED   36206490
REFERENCE   5  (residues 1 to 91)
  AUTHORS   Brahma MK, Xiao P, Popa M, Negueruela J, Vandenbempt V, Demine S,
            Cardozo AK and Gurzov EN.
  TITLE     Nova1 or Bim Deficiency in Pancreatic beta-Cells Does Not Alter
            Multiple Low-Dose Streptozotocin-Induced Diabetes and Diet-Induced
            Obesity in Mice
  JOURNAL   Nutrients 14 (18), 3866 (2022)
   PUBMED   36145242
  REMARK    GeneRIF: Nova1 or Bim Deficiency in Pancreatic beta-Cells Does Not
            Alter Multiple Low-Dose Streptozotocin-Induced Diabetes and
            Diet-Induced Obesity in Mice.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 91)
  AUTHORS   Bouillet P, Zhang LC, Huang DC, Webb GC, Bottema CD, Shore P, Eyre
            HJ, Sutherland GR and Adams JM.
  TITLE     Gene structure alternative splicing, and chromosomal localization
            of pro-apoptotic Bcl-2 relative Bim
  JOURNAL   Mamm Genome 12 (2), 163-168 (2001)
   PUBMED   11210187
REFERENCE   7  (residues 1 to 91)
  AUTHORS   Bouillet P, Metcalf D, Huang DC, Tarlinton DM, Kay TW, Kontgen F,
            Adams JM and Strasser A.
  TITLE     Proapoptotic Bcl-2 relative Bim required for certain apoptotic
            responses, leukocyte homeostasis, and to preclude autoimmunity
  JOURNAL   Science 286 (5445), 1735-1738 (1999)
   PUBMED   10576740
REFERENCE   8  (residues 1 to 91)
  AUTHORS   Puthalakath H, Huang DC, O'Reilly LA, King SM and Strasser A.
  TITLE     The proapoptotic activity of the Bcl-2 family member Bim is
            regulated by interaction with the dynein motor complex
  JOURNAL   Mol Cell 3 (3), 287-296 (1999)
   PUBMED   10198631
REFERENCE   9  (residues 1 to 91)
  AUTHORS   Reed JC.
  TITLE     Bcl-2 family proteins
  JOURNAL   Oncogene 17 (25), 3225-3236 (1998)
   PUBMED   9916985
  REMARK    Review article
REFERENCE   10 (residues 1 to 91)
  AUTHORS   O'Connor L, Strasser A, O'Reilly LA, Hausmann G, Adams JM, Cory S
            and Huang DC.
  TITLE     Bim: a novel member of the Bcl-2 family that promotes apoptosis
  JOURNAL   EMBO J 17 (2), 384-395 (1998)
   PUBMED   9430630
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK037885.1 and AK162975.1.
            
            On Mar 21, 2014 this sequence version replaced XP_006498681.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK037885.1, BB631162.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..91
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 62.23 cM"
     Protein         1..91
                     /product="bcl-2-like protein 11 isoform 4"
                     /note="bcl-2-like protein 11; bcl2-interacting mediator of
                     cell death; Bcl2 interacting mediator of cell death;
                     BCL2-like 11 (apoptosis facilitator)"
                     /calculated_mol_wt=9862
     Region          4..40
                     /region_name="Bim_N"
                     /note="Bim protein N-terminus; pfam06773"
                     /db_xref="CDD:429111"
     CDS             1..91
                     /gene="Bcl2l11"
                     /gene_synonym="1500006F24Rik; bcl2-L-11; Bim; Bod"
                     /coded_by="NM_001291016.1:229..504"
                     /note="isoform 4 is encoded by transcript variant 5"
                     /db_xref="CCDS:CCDS71141.1"
                     /db_xref="GeneID:12125"
                     /db_xref="MGI:MGI:1197519"
ORIGIN      
        1 makqpsdvss ecdreggqlq paerppqlrp gaptslqtep qdrspapmsc dkstqtpspp
       61 cqafnhylsa mdqlenlnqv aqnihgdawy n
//
LOCUS       NP_032603                526 aa            linear   ROD 09-OCT-2023
DEFINITION  amino acid transporter heavy chain SLC3A2 isoform b [Mus musculus].
ACCESSION   NP_032603
VERSION     NP_032603.3
DBSOURCE    REFSEQ: accession NM_008577.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 526)
  AUTHORS   Xiang P, Chen Q, Chen L, Lei J, Yuan Z, Hu H, Lu Y, Wang X, Wang T,
            Yu R, Zhang W, Zhang J, Yu C and Ma L.
  TITLE     Metabolite Neu5Ac triggers SLC3A2 degradation promoting vascular
            endothelial ferroptosis and aggravates atherosclerosis progression
            in ApoE-/-mice
  JOURNAL   Theranostics 13 (14), 4993-5016 (2023)
   PUBMED   37771765
  REMARK    GeneRIF: Metabolite Neu5Ac triggers SLC3A2 degradation promoting
            vascular endothelial ferroptosis and aggravates atherosclerosis
            progression in ApoE[-/-]mice.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 526)
  AUTHORS   Puris E, Saveleva L, de Sousa Maciel I, Kanninen KM, Auriola S and
            Fricker G.
  TITLE     Protein Expression of Amino Acid Transporters Is Altered in
            Isolated Cerebral Microvessels of 5xFAD Mouse Model of Alzheimer's
            Disease
  JOURNAL   Mol Neurobiol 60 (2), 732-748 (2023)
   PUBMED   36367657
  REMARK    GeneRIF: Protein Expression of Amino Acid Transporters Is Altered
            in Isolated Cerebral Microvessels of 5xFAD Mouse Model of
            Alzheimer's Disease.
REFERENCE   3  (residues 1 to 526)
  AUTHORS   Eom J, Choi J, Suh SS and Seo JB.
  TITLE     SLC3A2 and SLC7A2 Mediate the Exogenous Putrescine-Induced
            Adipocyte Differentiation
  JOURNAL   Mol Cells 45 (12), 963-975 (2022)
   PUBMED   36572564
  REMARK    GeneRIF: SLC3A2 and SLC7A2 Mediate the Exogenous Putrescine-Induced
            Adipocyte Differentiation.
REFERENCE   4  (residues 1 to 526)
  AUTHORS   Chen Q, Liu L and Ni S.
  TITLE     Screening of ferroptosis-related genes in sepsis-induced liver
            failure and analysis of immune correlation
  JOURNAL   PeerJ 10, e13757 (2022)
   PUBMED   35923893
  REMARK    GeneRIF: Screening of ferroptosis-related genes in sepsis-induced
            liver failure and analysis of immune correlation.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 526)
  AUTHORS   Salazar-Petres E, Pereira-Carvalho D, Lopez-Tello J and
            Sferruzzi-Perri AN.
  TITLE     Placental structure, function, and mitochondrial phenotype relate
            to fetal size in each fetal sex in micedagger
  JOURNAL   Biol Reprod 106 (6), 1292-1311 (2022)
   PUBMED   35293971
REFERENCE   6  (residues 1 to 526)
  AUTHORS   Rochelle JM, Watson ML, Oakey RJ and Seldin MF.
  TITLE     A linkage map of mouse chromosome 19: definition of comparative
            mapping relationships with human chromosomes 10 and 11 including
            the MEN1 locus
  JOURNAL   Genomics 14 (1), 26-31 (1992)
   PUBMED   1358795
REFERENCE   7  (residues 1 to 526)
  AUTHORS   Fowler KJ, Clouston WM, Fournier RE and Evans BA.
  TITLE     The relaxin gene is located on chromosome 19 in the mouse
  JOURNAL   FEBS Lett 292 (1-2), 183-186 (1991)
   PUBMED   1959604
REFERENCE   8  (residues 1 to 526)
  AUTHORS   Horlick KR, Cheng IC, Wong WT, Wakeland EK and Nick HS.
  TITLE     Mouse lipocortin I gene structure and chromosomal assignment: gene
            duplication and the origins of a gene family
  JOURNAL   Genomics 10 (2), 365-374 (1991)
   PUBMED   1676980
REFERENCE   9  (residues 1 to 526)
  AUTHORS   Chainani M, Sampsell B and Elliott RW.
  TITLE     Localization of the gene for plasma retinol binding protein to the
            distal half of mouse chromosome 19
  JOURNAL   Genomics 9 (2), 376-379 (1991)
   PUBMED   2004789
REFERENCE   10 (residues 1 to 526)
  AUTHORS   Levanon D, Hsieh CL, Francke U, Dawson PA, Ridgway ND, Brown MS and
            Goldstein JL.
  TITLE     cDNA cloning of human oxysterol-binding protein and localization of
            the gene to human chromosome 11 and mouse chromosome 19
  JOURNAL   Genomics 7 (1), 65-74 (1990)
   PUBMED   1970801
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC025794.9.
            
            On May 30, 2009 this sequence version replaced NP_032603.2.
            
            Transcript Variant: This variant (2) differs in the 5' coding
            region and 5' UTR, compared to variant 1. This results in a shorter
            and distinct N-terminus in isoform b, compared to isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC065173.1, AB023408.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..526
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 5.44 cM"
     Protein         1..526
                     /product="amino acid transporter heavy chain SLC3A2
                     isoform b"
                     /note="antigen identified by monoclonal antibodies 4F2;
                     4F2 cell-surface antigen heavy chain; CD98 heavy chain;
                     type II transmembrane protein; CD98 antigen; solute
                     carrier family 3 member 2; amino acid transporter heavy
                     chain SLC3A2"
                     /calculated_mol_wt=58206
     Region          1..31
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P10852.1)"
     Site            2
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P08195; propagated from
                     UniProtKB/Swiss-Prot (P10852.1)"
     Site            5
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q794F9; propagated from
                     UniProtKB/Swiss-Prot (P10852.1)"
     Region          40..118
                     /region_name="SLC3A2_N"
                     /note="Solute carrier family 3 member 2 N-terminus;
                     pfam16028"
                     /db_xref="CDD:435083"
     Site            58
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19144319,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P10852.1)"
     Site            76..99
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P10852.1)"
     Region          100..429
                     /region_name="AmyAc_family"
                     /note="Alpha amylase catalytic domain family; cl38930"
                     /db_xref="CDD:453893"
     Site            166
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19349973,
                     ECO:0000269|PubMed:19656770; propagated from
                     UniProtKB/Swiss-Prot (P10852.1)"
     Site            order(205,240,242,273,332..333)
                     /site_type="active"
                     /db_xref="CDD:200451"
     Site            order(242,273,333)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:200451"
     Site            259
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19349973,
                     ECO:0000269|PubMed:19656770; propagated from
                     UniProtKB/Swiss-Prot (P10852.1)"
     Site            263
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P10852.1)"
     Site            300
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P08195; propagated from
                     UniProtKB/Swiss-Prot (P10852.1)"
     Site            301
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P10852.1)"
     Site            302
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P08195; propagated from
                     UniProtKB/Swiss-Prot (P10852.1)"
     Site            318
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000250|UniProtKB:P08195; propagated from
                     UniProtKB/Swiss-Prot (P10852.1)"
     Site            385
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19349973,
                     ECO:0000269|PubMed:19656770; propagated from
                     UniProtKB/Swiss-Prot (P10852.1)"
     Site            399
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19349973,
                     ECO:0000269|PubMed:19656770; propagated from
                     UniProtKB/Swiss-Prot (P10852.1)"
     Site            420
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P08195; propagated from
                     UniProtKB/Swiss-Prot (P10852.1)"
     Site            509
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P10852.1)"
     CDS             1..526
                     /gene="Slc3a2"
                     /gene_synonym="4F2; 4F2HC; Cd98; Ly-10; Ly-m10; Ly10;
                     Mdu1; Mgp-2hc; NACAE"
                     /coded_by="NM_008577.5:151..1731"
                     /note="isoform b is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS29540.1"
                     /db_xref="GeneID:17254"
                     /db_xref="MGI:MGI:96955"
ORIGIN      
        1 msqdtevdmk dvelnelepe kqpmnaadga aageknglvk ikvaedetea gvkftglske
       61 ellkvagspg wvrtrwalll lfwlgwlgml agavviivra prcrelpvqr wwhkgalyri
      121 gdlqafvgrd aggiaglksh leylstlkvk glvlgpihkn qkdeinetdl kqinptlgsq
      181 edfkdllqsa kkksihiild ltpnyqgqna wflpaqadiv atkmkealss wlqdgvdgfq
      241 frdvgklmna plylaewqni tknlsedrll iagtessdlq qivnilests dllltssyls
      301 nstftgerte slvtrflnat gsqwcswsvs qaglladfip dhllrlyqll lftlpgtpvf
      361 sygdelglqg alpgqpakap lmpwnessif hiprpvslnm tvkgqnedpg slltqfrrls
      421 dlrgkersll hgdfhalsss pdlfsyirhw dqnerylvvl nfrdsgrsar lgasnlpagi
      481 slpasaklll stdsarqsre edtslklenl slnpyeglll qfpfva
//
LOCUS       NP_001351565             385 aa            linear   ROD 09-OCT-2023
DEFINITION  RNA-binding protein Nova-1 isoform 4 [Mus musculus].
ACCESSION   NP_001351565 XP_006516216
VERSION     NP_001351565.1
DBSOURCE    REFSEQ: accession NM_001364636.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 385)
  AUTHORS   Tajima Y, Ito K, Yuan Y, Frank MO, Saito Y and Darnell RB.
  TITLE     NOVA1 acts on Impact to regulate hypothalamic function and
            translation in inhibitory neurons
  JOURNAL   Cell Rep 42 (2), 112050 (2023)
   PUBMED   36716149
  REMARK    GeneRIF: NOVA1 acts on Impact to regulate hypothalamic function and
            translation in inhibitory neurons.
REFERENCE   2  (residues 1 to 385)
  AUTHORS   Brahma MK, Xiao P, Popa M, Negueruela J, Vandenbempt V, Demine S,
            Cardozo AK and Gurzov EN.
  TITLE     Nova1 or Bim Deficiency in Pancreatic beta-Cells Does Not Alter
            Multiple Low-Dose Streptozotocin-Induced Diabetes and Diet-Induced
            Obesity in Mice
  JOURNAL   Nutrients 14 (18), 3866 (2022)
   PUBMED   36145242
  REMARK    GeneRIF: Nova1 or Bim Deficiency in Pancreatic beta-Cells Does Not
            Alter Multiple Low-Dose Streptozotocin-Induced Diabetes and
            Diet-Induced Obesity in Mice.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 385)
  AUTHORS   Krach F, Wheeler EC, Regensburger M, Boerstler T, Wend H, Vu AQ,
            Wang R, Reischl S, Boldt K, Batra R, Aigner S, Ravits J, Winkler J,
            Yeo GW and Winner B.
  TITLE     Aberrant NOVA1 function disrupts alternative splicing in early
            stages of amyotrophic lateral sclerosis
  JOURNAL   Acta Neuropathol 144 (3), 413-435 (2022)
   PUBMED   35778567
  REMARK    GeneRIF: Aberrant NOVA1 function disrupts alternative splicing in
            early stages of amyotrophic lateral sclerosis.
REFERENCE   4  (residues 1 to 385)
  AUTHORS   Li D, Shen M, Deng X and Bai Y.
  TITLE     MicroRNA miR-27a-3p accelerates cardiac hypertrophy by targeting
            neuro-oncological ventral antigen 1
  JOURNAL   Bioengineered 13 (4), 8982-8993 (2022)
   PUBMED   35348441
  REMARK    GeneRIF: MicroRNA miR-27a-3p accelerates cardiac hypertrophy by
            targeting neuro-oncological ventral antigen 1.
REFERENCE   5  (residues 1 to 385)
  AUTHORS   Johnson V, Junge HJ and Chen Z.
  TITLE     Temporal regulation of axonal repulsion by alternative splicing of
            a conserved microexon in mammalian Robo1 and Robo2
  JOURNAL   Elife 8, e46042 (2019)
   PUBMED   31392959
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 385)
  AUTHORS   Jensen KB, Dredge BK, Stefani G, Zhong R, Buckanovich RJ, Okano HJ,
            Yang YY and Darnell RB.
  TITLE     Nova-1 regulates neuron-specific alternative splicing and is
            essential for neuronal viability
  JOURNAL   Neuron 25 (2), 359-371 (2000)
   PUBMED   10719891
REFERENCE   7  (residues 1 to 385)
  AUTHORS   Yang YY, Yin GL and Darnell RB.
  TITLE     The neuronal RNA-binding protein Nova-2 is implicated as the
            autoantigen targeted in POMA patients with dementia
  JOURNAL   Proc Natl Acad Sci U S A 95 (22), 13254-13259 (1998)
   PUBMED   9789075
REFERENCE   8  (residues 1 to 385)
  AUTHORS   Fletcher CF, Okano HJ, Gilbert DJ, Yang Y, Yang C, Copeland NG,
            Jenkins NA and Darnell RB.
  TITLE     Mouse chromosomal locations of nine genes encoding homologs of
            human paraneoplastic neurologic disorder antigens
  JOURNAL   Genomics 45 (2), 313-319 (1997)
   PUBMED   9344654
REFERENCE   9  (residues 1 to 385)
  AUTHORS   Buckanovich RJ and Darnell RB.
  TITLE     The neuronal RNA binding protein Nova-1 recognizes specific RNA
            targets in vitro and in vivo
  JOURNAL   Mol Cell Biol 17 (6), 3194-3201 (1997)
   PUBMED   9154818
REFERENCE   10 (residues 1 to 385)
  AUTHORS   Buckanovich RJ, Yang YY and Darnell RB.
  TITLE     The onconeural antigen Nova-1 is a neuron-specific RNA-binding
            protein, the activity of which is inhibited by paraneoplastic
            antibodies
  JOURNAL   J Neurosci 16 (3), 1114-1122 (1996)
   PUBMED   8558240
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156636.2, AC108802.15 and CT009504.11.
            
            On Jun 26, 2018 this sequence version replaced XP_006516216.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.751283.1,
                                           SRR7345562.2309346.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164136
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..385
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 21.46 cM"
     Protein         1..385
                     /product="RNA-binding protein Nova-1 isoform 4"
                     /note="RNA-binding protein Nova-1; ventral neuron-specific
                     protein 1; neuro-oncological ventral antigen 1"
                     /calculated_mol_wt=38594
     Region          50..119
                     /region_name="KH-I_NOVA_rpt2"
                     /note="second type I K homology (KH) RNA-binding domain
                     found in the family of neuro-oncological ventral antigen
                     (Nova); cd22436"
                     /db_xref="CDD:411864"
     Site            order(61..63,65..69,72..73,83..85,87..89,97)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:411864"
     Region          300..370
                     /region_name="KH-I_NOVA_rpt3"
                     /note="third type I K homology (KH) RNA-binding domain
                     found in the family of neuro-oncological ventral antigen
                     (Nova); cd09031"
                     /db_xref="CDD:411807"
     Site            order(308..309,311..313,315..319,322..323,333..339,341,
                     346,348)
                     /site_type="other"
                     /note="RNA binding site [nucleotide binding]"
                     /db_xref="CDD:411807"
     CDS             1..385
                     /gene="Nova1"
                     /gene_synonym="9430099M15Rik; G630039L02; Nova-1"
                     /coded_by="NM_001364636.1:485..1642"
                     /note="isoform 4 is encoded by transcript variant 4"
                     /db_xref="GeneID:664883"
                     /db_xref="MGI:MGI:104297"
ORIGIN      
        1 mpqnvaktep vsilqpqttv npdrikqtlp ssptttkssp sdpmttsran qvkiivpnst
       61 agliigkgga tvkaimeqsg awvqlsqkpd ginlqervvt vsgepeqnrk aveliiqkiq
      121 edpqsgscln isyanvtgpv ansnptgspy antaevlpta aaaagllgha nlagvaafpa
      181 vlsgftgndl vaitsalntl asygynlntl glglsqaaat galaaaaasa npaaaaanll
      241 atyaseasas gstaggtagt falgslaaat aatngyfgaa splaasailg tekstdgskd
      301 vveiavpenl vgailgkggk tlveyqeltg ariqiskkge fvpgtrnrkv titgtpaatq
      361 aaqylitqri tyeqgvraan pqkvg
//
LOCUS       NP_058057                773 aa            linear   ROD 09-OCT-2023
DEFINITION  nuclear autoantigenic sperm protein isoform 2 [Mus musculus].
ACCESSION   NP_058057
VERSION     NP_058057.3
DBSOURCE    REFSEQ: accession NM_016777.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 773)
  AUTHORS   Bao Y, Lian M, Chen Y, Gu X, Cao K, Du X and Ju J.
  TITLE     sNASP Mutation Aggravates to the TLR4-Mediated Inflammation in SLE
            by TAK1 Pathway
  JOURNAL   J Immunol Res 2023, 4877700 (2023)
   PUBMED   37771504
  REMARK    GeneRIF: sNASP Mutation Aggravates to the TLR4-Mediated
            Inflammation in SLE by TAK1 Pathway.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 773)
  AUTHORS   Li J, Jiang H, Mu Y, Wei Z, Ma A, Sun M, Zhao J, Zhu C and Chen X.
  TITLE     SRSF10 regulates proliferation of neural progenitor cells and
            affects neurogenesis in developing mouse neocortex
  JOURNAL   iScience 26 (7), 107042 (2023)
   PUBMED   37360696
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 773)
  AUTHORS   Zhang Y, Yan H, Zhu J, Chen L, Wang H and Ju J.
  TITLE     [Hepatic fibrosis aggravation in nuclear autoantigenic sperm
            protein (NASP) mutant mice induced by concanavalin A]
  JOURNAL   Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 38 (7), 577-583 (2022)
   PUBMED   35786450
  REMARK    GeneRIF: [Hepatic fibrosis aggravation in nuclear autoantigenic
            sperm protein (NASP) mutant mice induced by concanavalin A].
REFERENCE   4  (residues 1 to 773)
  AUTHORS   Zhang J, Du X, Wang H, Bao Y, Lian M, Xu Z and Ju J.
  TITLE     A Variant of sNASP Exacerbates Lymphocyte Subset Disorder and
            Nephritis in a Spontaneous Lupus Model Sle1.Yaa Mouse
  JOURNAL   Mediators Inflamm 2021, 8175863 (2021)
   PUBMED   34720750
  REMARK    GeneRIF: A Variant of sNASP Exacerbates Lymphocyte Subset Disorder
            and Nephritis in a Spontaneous Lupus Model Sle1.Yaa Mouse.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 773)
  AUTHORS   Ju J, Xu J, Zhu Y, Fu X, Morel L and Xu Z.
  TITLE     A Variant of the Histone-Binding Protein sNASP Contributes to Mouse
            Lupus
  JOURNAL   Front Immunol 10, 637 (2019)
   PUBMED   31001259
  REMARK    GeneRIF: A Variant of the Histone-Binding Protein sNASP Contributes
            to Mouse Lupus.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 773)
  AUTHORS   Piao Y, Ko NT, Lim MK and Ko MS.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   7  (residues 1 to 773)
  AUTHORS   Richardson RT, Bencic DC and O'Rand MG.
  TITLE     Comparison of mouse and human NASP genes and expression in human
            transformed and tumor cell lines
  JOURNAL   Gene 274 (1-2), 67-75 (2001)
   PUBMED   11674998
REFERENCE   8  (residues 1 to 773)
  AUTHORS   Richardson RT, Batova IN, Widgren EE, Zheng LX, Whitfield M,
            Marzluff WF and O'Rand MG.
  TITLE     Characterization of the histone H1-binding protein, NASP, as a cell
            cycle-regulated somatic protein
  JOURNAL   J Biol Chem 275 (39), 30378-30386 (2000)
   PUBMED   10893414
REFERENCE   9  (residues 1 to 773)
  AUTHORS   Hemberger M, Himmelbauer H, Ruschmann J, Zeitz C and Fundele R.
  TITLE     cDNA subtraction cloning reveals novel genes whose temporal and
            spatial expression indicates association with trophoblast invasion
  JOURNAL   Dev Biol 222 (1), 158-169 (2000)
   PUBMED   10885754
REFERENCE   10 (residues 1 to 773)
  AUTHORS   Leimeister C, Bach A, Woolf AS and Gessler M.
  TITLE     Screen for genes regulated during early kidney morphogenesis
  JOURNAL   Dev Genet 24 (3-4), 273-283 (1999)
   PUBMED   10322635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX004835.3 and AL669953.7.
            
            On Feb 9, 2007 this sequence version replaced NP_058057.2.
            
            Transcript Variant: This variant (2) represents the longest
            transcript and encodes the longest isoform (2).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF034610.2, SRR7345562.2481421.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164141
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..773
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 53.24 cM"
     Protein         1..773
                     /product="nuclear autoantigenic sperm protein isoform 2"
                     /note="somatic histone binding protein NASP"
                     /calculated_mol_wt=83882
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q99MD9.2)"
     Site            33
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q99MD9.2)"
     Region          43..76
                     /region_name="TPR 1. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99MD9.2)"
     Region          115..244
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99MD9.2)"
     Region          116..127
                     /region_name="Histone-binding.
                     /evidence=ECO:0000250|UniProtKB:P49321"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99MD9.2)"
     Site            123
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q99MD9.2)"
     Site            127
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q99MD9.2)"
     Site            169
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q99MD9.2)"
     Site            175
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q99MD9.2)"
     Site            188
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q99MD9.2)"
     Region          210..242
                     /region_name="Histone-binding.
                     /evidence=ECO:0000250|UniProtKB:P49321"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99MD9.2)"
     Region          237..270
                     /region_name="TPR 2. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99MD9.2)"
     Site            241
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (Q99MD9.2)"
     Site            242
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q99MD9.2)"
     Region          <250..505
                     /region_name="2A1904"
                     /note="K+-dependent Na+/Ca+ exchanger; TIGR00927"
                     /db_xref="CDD:273344"
     Site            251
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (Q99MD9.2)"
     Region          258..284
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99MD9.2)"
     Site            284
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (Q99MD9.2)"
     Region          301..321
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99MD9.2)"
     Site            304
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q66HD3; propagated from
                     UniProtKB/Swiss-Prot (Q99MD9.2)"
     Site            319
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q99MD9.2)"
     Region          349..493
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99MD9.2)"
     Site            377
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q99MD9.2)"
     Site            384
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q99MD9.2)"
     Site            395
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q99MD9.2)"
     Site            396
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q66HD3; propagated from
                     UniProtKB/Swiss-Prot (Q99MD9.2)"
     Site            450
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q99MD9.2)"
     Region          455..498
                     /region_name="Histone-binding.
                     /evidence=ECO:0000250|UniProtKB:P49321"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99MD9.2)"
     Site            463
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q99MD9.2)"
     Site            466
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q99MD9.2)"
     Site            483
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q99MD9.2)"
     Site            489
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q99MD9.2)"
     Region          497..520
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          526..602
                     /region_name="TPR_12"
                     /note="Tetratricopeptide repeat; pfam13424"
                     /db_xref="CDD:315987"
     Region          528..565
                     /region_name="SHNi-TPR"
                     /note="pfam10516"
                     /db_xref="CDD:402238"
     Region          528..561
                     /region_name="TPR 3. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99MD9.2)"
     Region          528..556
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(529,532..533,536..537,539,571,574..575,578..579,
                     581..582,603,606..607,610)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          561..599
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          570..603
                     /region_name="TPR 4. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99MD9.2)"
     Site            648
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q99MD9.2)"
     Site            669
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q99MD9.2)"
     Region          683..773
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99MD9.2)"
     Site            691
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q99MD9.2)"
     Site            692
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q99MD9.2)"
     Region          702..708
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99MD9.2)"
     Site            712
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q99MD9.2)"
     Site            731
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q99MD9.2)"
     Site            737
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q99MD9.2)"
     Site            742
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49321; propagated from
                     UniProtKB/Swiss-Prot (Q99MD9.2)"
     CDS             1..773
                     /gene="Nasp"
                     /gene_synonym="5033430J04Rik; D4Ertd767e; Epcs32; Nasp-T"
                     /coded_by="NM_016777.3:102..2423"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS18513.1"
                     /db_xref="GeneID:50927"
                     /db_xref="MGI:MGI:1355328"
ORIGIN      
        1 matestaaaa iaaelvsadk iedapapsts adkmesldvd seakkllglg qkhlvmgdip
       61 aavnafqeaa sllgkkyget anecgeafff ygksllelar mengvlgnal egvhveeeeg
      121 ektedeslve nndnvdeear eelreqvyda mgekeakkae gksltkpetd keqesevekg
      181 gredmdisep eeklqetvep tskqltesse eakeaaipgl nedevasgkt eqeslctekg
      241 ksisgayvqn kefretveeg eeiislekkp ketsedqpir aaekqgtlmk vveieaeidp
      301 qvksadvgge epkdqvatse selgkavlme lsgqdveasp vvaaeagaev sekpgqeitv
      361 ipnngpvvgq stvgdqtpse pqtsaerlte tkdgssveev kaelvpeqee amlpveesea
      421 agdgvetkva qratekaped kfkiaaneet qerdeqmkeg eetegseeed rendkaeetp
      481 nesvlekksl qeneeeeign lelawdmldl akiifkrqet keaqlyaaqa hlklgevsve
      541 senyiqavee fqaclslqeq yleahdrlla ethyqlglay gynsqydeav aqfgksidvi
      601 ekrmavlheq mkeaegsfte yekeieelke llpeirekie dakesqrsgn vaelalkatl
      661 vesstsgftp sgagasvsmi asrkptdgas ssncvtdish lvrkkrkpee esprkddakk
      721 akqepevngg sgdavssgke vsenmeaeae nqaesqtaeg tvesaatiks tac
//
LOCUS       NP_001017426            1641 aa            linear   ROD 09-OCT-2023
DEFINITION  lysine-specific demethylase 6B [Mus musculus].
ACCESSION   NP_001017426 XP_006532961 XP_126426
VERSION     NP_001017426.1
DBSOURCE    REFSEQ: accession NM_001017426.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1641)
  AUTHORS   Phan QM, Salz L, Kindl SS, Lopez JS, Thompson SM, Makkar J,
            Driskell IM and Driskell RR.
  TITLE     Lineage commitment of dermal fibroblast progenitors is controlled
            by Kdm6b-mediated chromatin demethylation
  JOURNAL   EMBO J 42 (19), e113880 (2023)
   PUBMED   37602956
  REMARK    GeneRIF: Lineage commitment of dermal fibroblast progenitors is
            controlled by Kdm6b-mediated chromatin demethylation.
REFERENCE   2  (residues 1 to 1641)
  AUTHORS   Chen A, Sun Z, Sun D, Huang M, Fang H, Zhang J and Qian G.
  TITLE     Integrative bioinformatics and validation studies reveal KDM6B and
            its associated molecules as crucial modulators in Idiopathic
            Pulmonary Fibrosis
  JOURNAL   Front Immunol 14, 1183871 (2023)
   PUBMED   37275887
  REMARK    GeneRIF: Integrative bioinformatics and validation studies reveal
            KDM6B and its associated molecules as crucial modulators in
            Idiopathic Pulmonary Fibrosis.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1641)
  AUTHORS   Dror E, Fagnocchi L, Wegert V, Apostle S, Grimaldi B, Gruber T,
            Panzeri I, Heyne S, Hoffler KD, Kreiner V, Ching R, Tsai-Hsiu Lu T,
            Semwal A, Johnson B, Senapati P, Lempradl A, Schones D, Imhof A,
            Shen H and Pospisilik JA.
  TITLE     Epigenetic dosage identifies two major and functionally distinct
            beta cell subtypes
  JOURNAL   Cell Metab 35 (5), 821-836 (2023)
   PUBMED   36948185
REFERENCE   4  (residues 1 to 1641)
  AUTHORS   Issa N, Bjeije H, Wilson ER, Krishnan A, Dunuwille WMB, Parsons TM,
            Zhang CR, Han W, Young AL, Ren Z, Ge K, Wang ES, Weng AP, Cashen A,
            Spencer DH and Challen GA.
  TITLE     KDM6B protects T-ALL cells from NOTCH1-induced oncogenic stress
  JOURNAL   Leukemia 37 (4), 728-740 (2023)
   PUBMED   36797416
  REMARK    GeneRIF: KDM6B protects T-ALL cells from NOTCH1-induced oncogenic
            stress.
REFERENCE   5  (residues 1 to 1641)
  AUTHORS   Gao Y, Wang N and Jia D.
  TITLE     JMJD3 downregulates IL4i1 aggravating lipopolysaccharide-induced
            acute lung injury via H3K27 and H3K4 demethylation
  JOURNAL   Environ Toxicol 38 (4), 754-769 (2023)
   PUBMED   36537648
  REMARK    GeneRIF: JMJD3 downregulates IL4i1 aggravating
            lipopolysaccharide-induced acute lung injury via H3K27 and H3K4
            demethylation.
REFERENCE   6  (residues 1 to 1641)
  AUTHORS   Hong S, Cho YW, Yu LR, Yu H, Veenstra TD and Ge K.
  TITLE     Identification of JmjC domain-containing UTX and JMJD3 as histone
            H3 lysine 27 demethylases
  JOURNAL   Proc Natl Acad Sci U S A 104 (47), 18439-18444 (2007)
   PUBMED   18003914
  REMARK    GeneRIF: UTX and JMJD3 may function as H3K27 demethylases in vivo
            GeneRIF: JMJD3 demethylates di- and trimethylated lysine 27 of
            histone H3 in vitro and in cells.
REFERENCE   7  (residues 1 to 1641)
  AUTHORS   Jepsen K, Solum D, Zhou T, McEvilly RJ, Kim HJ, Glass CK, Hermanson
            O and Rosenfeld MG.
  TITLE     SMRT-mediated repression of an H3K27 demethylase in progression
            from neural stem cell to neuron
  JOURNAL   Nature 450 (7168), 415-419 (2007)
   PUBMED   17928865
  REMARK    GeneRIF: data reveal that SMRT represses expression of JMJD3, a
            direct retinoic-acid-receptor target that functions as a histone H3
            trimethyl K27 demethylase and which is capable of activating
            specific components of the neurogenic program
REFERENCE   8  (residues 1 to 1641)
  AUTHORS   De Santa F, Totaro MG, Prosperini E, Notarbartolo S, Testa G and
            Natoli G.
  TITLE     The histone H3 lysine-27 demethylase Jmjd3 links inflammation to
            inhibition of polycomb-mediated gene silencing
  JOURNAL   Cell 130 (6), 1083-1094 (2007)
   PUBMED   17825402
  REMARK    GeneRIF: Jmjd3 binds polycomb group protein target genes and
            regulates their histone H3 lysine 27 trimethylation levels and
            transcriptional activity. Provides a link between inflammation and
            reprogramming of the epigenome.
REFERENCE   9  (residues 1 to 1641)
  AUTHORS   Okazaki N, Kikuno R, Ohara R, Inamoto S, Koseki H, Hiraoka S, Saga
            Y, Nagase T, Ohara O and Koga H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   10 (residues 1 to 1641)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596125.27.
            
            On or before Jun 8, 2018 this sequence version replaced
            XP_006532961.1, XP_126426.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC075632.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1641
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.6 cM"
     Protein         1..1641
                     /product="lysine-specific demethylase 6B"
                     /EC_number="1.14.11.68"
                     /note="jumonji domain containing 3; jmjC domain-containing
                     protein 3; jumonji domain-containing protein 3; [histone
                     H3]-trimethyl-L-lysine(27) demethylase 6B"
                     /calculated_mol_wt=176225
     Region          42..89
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5NCY0.1)"
     Region          106..136
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          188..682
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5NCY0.1)"
     Site            224
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O15054; propagated from
                     UniProtKB/Swiss-Prot (Q5NCY0.1)"
     Region          704..808
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5NCY0.1)"
     Region          824..1085
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5NCY0.1)"
     Region          1286..1323
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5NCY0.1)"
     Region          1341..1405
                     /region_name="JmjC"
                     /note="A domain family that is part of the cupin
                     metalloenzyme superfamily; smart00558"
                     /db_xref="CDD:214721"
     Region          1375..1483
                     /region_name="JmjC"
                     /note="JmjC domain, hydroxylase; pfam02373"
                     /db_xref="CDD:396791"
     CDS             1..1641
                     /gene="Kdm6b"
                     /gene_synonym="1700064E03Rik; Jmjd3"
                     /coded_by="NM_001017426.2:587..5512"
                     /db_xref="CCDS:CCDS24895.1"
                     /db_xref="GeneID:216850"
                     /db_xref="MGI:MGI:2448492"
ORIGIN      
        1 mhravdppga rsareafalg glscagawss cpphppprss wlpggrcsas vgqpplsapl
       61 ppshgsssgh pnkpyyapgt ptprplhgkl eslhgcvqal lrepaqpglw eqlgqlyese
      121 hdseeavccy hralryggsf aelgprigrl qqaqlwnfha gscqhrakvl ppleqvwnll
      181 hlehkrnyga krggppvkrs aeppvvqpmp paalsgpsge eglspggkrr rgcsseqagl
      241 ppglplpppp pppppppppp pppppplpgl aisppfqltk pglwntlhgd awgperkgsa
      301 pperqeqrhs mphsypypap aysahppshr lvpntplgpg prppgaeshg clpatrppgs
      361 dlresrvqrs rmdssvspaa stacvpyaps rppglpgtss ssssssssnn tglrgvepsp
      421 gipgadhyqn paleisphqa rlgpsahssr kpfltapaat phlslppgtp ssppppcprl
      481 lrpppppawm kgsacraare dgeilgelff gaegpprppp pplphrdgfl gppnprfsvg
      541 tqdshnppip ptttssssss nshsssptgp vpfpppsyla rsidplprps sptlspqdpp
      601 lppltlalpp appsschqnt sgsfrrsesp rprvsfpktp evgqgpppgp vskapqpvpp
      661 gvgelpargp rlfdfpptpl edqfeepaef kilpdglani mkmldesirk eeeqqqqqea
      721 gvapppplke pfaslqppfp sdtapattta apttattttt ttttttqeee kkpppalppp
      781 pplakfpppp qpqppppppa spasllksla svlegqkycy rgtgaavstr pgsvpatqys
      841 pspasgatap pptsvapsaq gspkpsvsss sqfstsggpw arehrageep apgpvtpaql
      901 ppplplppar sesevleeis racetlverv grsainpvdt adpvdsgtep qpppaqakee
      961 sggvavaaag pgsgkrrqke hrrhrracrd svgrrpregr akakakapke ksrrvlgnld
     1021 lqseeiqgre karpdvggvs kvktptapap ppapapaaqp tppsapvpgk ktreeapgpp
     1081 gvsradmlkl rslsegppke lkirlikves gdketfiase veerrlrmad ltishcaadv
     1141 mrasknakvk gkfresylsp aqsvkpkint eeklprekln pptpsiyles krdafspvll
     1201 qfctdprnpi tvirglagsl rlnlglfstk tlveasgeht vevrtqvqqp sdenwdltgt
     1261 rqiwpcessr shttiakyaq yqassfqesl qeeresedee seepdsttgt spssapdpkn
     1321 hhiikfgtni dlsdakrwkp qlqellklpa fmrvtstgnm lshvghtilg mntvqlymkv
     1381 pgsrtpghqe nnnfcsvnin igpgdcewfa vhehywetis afcdrhgvdy ltgswwpild
     1441 dlyasnipvy rfvqrpgdlv winagtvhwv qatgwcnnia wnvgpltayq yqlaleryew
     1501 nevknvksiv pmihvswnva rtvkisdpdl fkmikfcllq smkhcqvqre slvragkkia
     1561 yqgrvkdepa yycnecdvev fnilfvtsen gsrntylvhc egcarrrsag lqgvvvleqy
     1621 rteelaqayd aftlapasts r
//
LOCUS       NP_001165677             589 aa            linear   ROD 09-OCT-2023
DEFINITION  AT-rich interactive domain-containing protein 5A isoform 2 [Mus
            musculus].
ACCESSION   NP_001165677
VERSION     NP_001165677.1
DBSOURCE    REFSEQ: accession NM_001172206.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 589)
  AUTHORS   Li X, Hua S, Fang D, Fei X, Tan Z, Zheng F, Wang W and Fang M.
  TITLE     RAGE deficiency ameliorates autoimmune hepatitis involving
            inhibition of IL-6 production via suppressing protein Arid5a in
            mice
  JOURNAL   Clin Exp Med 23 (6), 2167-2179 (2023)
   PUBMED   36454447
  REMARK    GeneRIF: RAGE deficiency ameliorates autoimmune hepatitis involving
            inhibition of IL-6 production via suppressing protein Arid5a in
            mice.
REFERENCE   2  (residues 1 to 589)
  AUTHORS   Taylor TC, Li Y, Li DD, Majumder S, McGeachy MJ, Biswas PS, Gingras
            S and Gaffen SL.
  TITLE     Arid5a Mediates an IL-17-Dependent Pathway That Drives Autoimmunity
            but Not Antifungal Host Defense
  JOURNAL   J Immunol 209 (6), 1138-1145 (2022)
   PUBMED   35940634
  REMARK    GeneRIF: Arid5a Mediates an IL-17-Dependent Pathway That Drives
            Autoimmunity but Not Antifungal Host Defense.
REFERENCE   3  (residues 1 to 589)
  AUTHORS   Catela C, Chen Y, Weng Y, Wen K and Kratsios P.
  TITLE     Control of spinal motor neuron terminal differentiation through
            sustained Hoxc8 gene activity
  JOURNAL   Elife 11, e70766 (2022)
   PUBMED   35315772
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 589)
  AUTHORS   Nyati KK, Hashimoto S, Singh SK, Tekguc M, Metwally H, Liu YC,
            Okuzaki D, Gemechu Y, Kang S and Kishimoto T.
  TITLE     The novel long noncoding RNA AU021063, induced by IL-6/Arid5a
            signaling, exacerbates breast cancer invasion and metastasis by
            stabilizing Trib3 and activating the Mek/Erk pathway
  JOURNAL   Cancer Lett 520, 295-306 (2021)
   PUBMED   34389433
  REMARK    GeneRIF: The novel long noncoding RNA AU021063, induced by
            IL-6/Arid5a signaling, exacerbates breast cancer invasion and
            metastasis by stabilizing Trib3 and activating the Mek/Erk pathway.
REFERENCE   5  (residues 1 to 589)
  AUTHORS   Chalise JP, Hashimoto S, Parajuli G, Kang S, Singh SK, Gemechu Y,
            Metwally H, Nyati KK, Dubey PK, Zaman MM, Nagahama Y, Hamza H,
            Masuda K and Kishimoto T.
  TITLE     Feedback regulation of Arid5a and Ppar-gamma2 maintains adipose
            tissue homeostasis
  JOURNAL   Proc Natl Acad Sci U S A 116 (30), 15128-15133 (2019)
   PUBMED   31289228
  REMARK    GeneRIF: Feedback regulation of Arid5a and Ppar-gamma2 maintains
            adipose tissue homeostasis.
REFERENCE   6  (residues 1 to 589)
  AUTHORS   Zaman MM, Masuda K, Nyati KK, Dubey PK, Ripley B, Wang K, Chalise
            JP, Higa M, Hanieh H and Kishimoto T.
  TITLE     Arid5a exacerbates IFN-gamma-mediated septic shock by stabilizing
            T-bet mRNA
  JOURNAL   Proc Natl Acad Sci U S A 113 (41), 11543-11548 (2016)
   PUBMED   27671645
  REMARK    GeneRIF: Arid5a deficiency resulted in decreased levels of
            IFN-gamma under Th1 cell conditions, in which T-box expressed in T
            cells (T-bet) mRNA expression was inhibited.
REFERENCE   7  (residues 1 to 589)
  AUTHORS   Masuda K, Ripley B, Nyati KK, Dubey PK, Zaman MM, Hanieh H, Higa M,
            Yamashita K, Standley DM, Mashima T, Katahira M, Okamoto T,
            Matsuura Y, Takeuchi O and Kishimoto T.
  TITLE     Arid5a regulates naive CD4+ T cell fate through selective
            stabilization of Stat3 mRNA
  JOURNAL   J Exp Med 213 (4), 605-619 (2016)
   PUBMED   27022145
  REMARK    GeneRIF: T cell-intrinsic role of Arid5a on fate decisions of naive
            CD4(+)T cells through selective stabilization of Stat3 mRNA.
REFERENCE   8  (residues 1 to 589)
  AUTHORS   Masuda K, Ripley B, Nishimura R, Mino T, Takeuchi O, Shioi G,
            Kiyonari H and Kishimoto T.
  TITLE     Arid5a controls IL-6 mRNA stability, which contributes to elevation
            of IL-6 level in vivo
  JOURNAL   Proc Natl Acad Sci U S A 110 (23), 9409-9414 (2013)
   PUBMED   23676272
  REMARK    GeneRIF: Arid5a controls IL-6 mRNA stability, which contributes to
            elevation of IL-6 level in vivo.
REFERENCE   9  (residues 1 to 589)
  AUTHORS   Amano K, Hata K, Muramatsu S, Wakabayashi M, Takigawa Y, Ono K,
            Nakanishi M, Takashima R, Kogo M, Matsuda A, Nishimura R and Yoneda
            T.
  TITLE     Arid5a cooperates with Sox9 to stimulate chondrocyte-specific
            transcription
  JOURNAL   Mol Biol Cell 22 (8), 1300-1311 (2011)
   PUBMED   21346191
  REMARK    GeneRIF: AT-rich interactive domain-containing protein 5a (Arid5a)
            cooperates with Sox9 to stimulate chondrocyte-specific
            transcription.
REFERENCE   10 (residues 1 to 589)
  AUTHORS   Wilsker D, Probst L, Wain HM, Maltais L, Tucker PW and Moran E.
  TITLE     Nomenclature of the ARID family of DNA-binding proteins
  JOURNAL   Genomics 86 (2), 242-251 (2005)
   PUBMED   15922553
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY196834.1, AK149839.1 and AK029237.1.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 5' coding region, compared to variant 1. This
            results in a shorter protein (isoform 2), compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BI555214.1, BE382286.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..589
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 15.2 cM"
     Protein         1..589
                     /product="AT-rich interactive domain-containing protein 5A
                     isoform 2"
                     /note="AT rich interactive domain 5A (Mrf1 like);
                     modulator recognition factor I; AT-rich interactive
                     domain-containing protein 5A; ARID domain-containing
                     protein 5A; AT rich interactive domain 5A (MRF1-like)"
                     /calculated_mol_wt=63697
     Region          55..137
                     /region_name="ARID_ARID5A"
                     /note="ARID/BRIGHT DNA binding domain of AT-rich
                     interactive domain-containing protein 5A (ARID5A) and
                     similar proteins; cd16884"
                     /db_xref="CDD:350648"
     Site            order(72..78,103,105..106,109,120,122..124,126)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:350648"
     CDS             1..589
                     /gene="Arid5a"
                     /gene_synonym="D430024K22Rik; Mrf1"
                     /coded_by="NM_001172206.1:101..1870"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="GeneID:214855"
                     /db_xref="MGI:MGI:2443039"
ORIGIN      
        1 mappakgnte qseegdlpql pvspkpddeq srsqsptqlq dspeaggeqe eeqaflvsly
       61 kfmkerhtpi ervphlgfkq inlwkiykav eklgayelvt grrlwknvyd elggspgsts
      121 aatctrrhye rlvlpyvrhl kgeddkplpp tkprkqykma kelrgddgtt eklkkakdse
      181 errveqttpg ktksdatgqt qlpcqgssrd steqlgpvsg psppltgass cpeaykrlls
      241 sfyckgahgi msplakkkll aqvskaealq cqeegcrhga rspnkdiqds pqnlrgpaen
      301 sehqltpreg lqapggstrm eaqvgpcpta pmfsgcfhay ptevlkpvsq hprdffsglk
      361 drvllgppgk eegpttkesh lvwggdanhp safhkgstrk rsfypkpkac wvspmakvpt
      421 erpgapsphp sspglgskrg leeegfahgg kklravspfl kevdsketgg kpaapglavs
      481 cllgptpgpt ppeayrgtml rcplnftgsa dplkgqaslp fsplvipafp ahllattgss
      541 pmaaslmhfp ptpydavlrn rlgpassawh mppvttyaap hffhlntkl
//
LOCUS       NP_001409071             823 aa            linear   ROD 09-OCT-2023
DEFINITION  hypoxia-inducible factor 1-alpha isoform 5 [Mus musculus].
ACCESSION   NP_001409071 XP_006515541
VERSION     NP_001409071.1
DBSOURCE    REFSEQ: accession NM_001422142.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 823)
  AUTHORS   Xu R, Shen S, Wang D, Ye J, Song S, Wang Z and Yue Z.
  TITLE     The role of HIF-1alpha-mediated autophagy in ionizing
            radiation-induced testicular injury
  JOURNAL   J Mol Histol 54 (5), 439-451 (2023)
   PUBMED   37728670
  REMARK    GeneRIF: The role of HIF-1alpha-mediated autophagy in ionizing
            radiation-induced testicular injury.
REFERENCE   2  (residues 1 to 823)
  AUTHORS   Yang Z, Su W, Wei X, Qu S, Zhao D, Zhou J, Wang Y, Guan Q, Qin C,
            Xiang J, Zen K and Yao B.
  TITLE     HIF-1alpha drives resistance to ferroptosis in solid tumors by
            promoting lactate production and activating SLC1A1
  JOURNAL   Cell Rep 42 (8), 112945 (2023)
   PUBMED   37542723
  REMARK    GeneRIF: HIF-1alpha drives resistance to ferroptosis in solid
            tumors by promoting lactate production and activating SLC1A1.
REFERENCE   3  (residues 1 to 823)
  AUTHORS   Dery KJ, Kojima H, Kageyama S, Kadono K, Hirao H, Cheng B, Zhai Y,
            Farmer DG, Kaldas FM, Yuan X, Eltzschig HK and Kupiec-Weglinski JW.
  TITLE     Alternative splicing of CEACAM1 by hypoxia-inducible factor-1alpha
            enhances tolerance to hepatic ischemia in mice and humans
  JOURNAL   Sci Transl Med 15 (707), eadf2059 (2023)
   PUBMED   37531413
  REMARK    GeneRIF: Alternative splicing of CEACAM1 by hypoxia-inducible
            factor-1alpha enhances tolerance to hepatic ischemia in mice and
            humans.
REFERENCE   4  (residues 1 to 823)
  AUTHORS   Guo Z, Yu X, Zhao S, Zhong X, Huang D, Feng R, Li P, Fang Z, Hu Y,
            Zhang Z, Abdurahman M, Huang L, Zhao Y, Wang X, Ge J and Li H.
  TITLE     SIRT6 deficiency in endothelial cells exacerbates oxidative stress
            by enhancing HIF1alpha accumulation and H3K9 acetylation at the
            Ero1alpha promoter
  JOURNAL   Clin Transl Med 13 (8), e1377 (2023)
   PUBMED   37598403
  REMARK    GeneRIF: SIRT6 deficiency in endothelial cells exacerbates
            oxidative stress by enhancing HIF1alpha accumulation and H3K9
            acetylation at the Ero1alpha promoter.
REFERENCE   5  (residues 1 to 823)
  AUTHORS   Zhang G, Liu B, Yang Y, Xie S, Chen L, Luo H, Zhong J, Wei Y, Guo
            F, Gan J, Zhu F, Xu L, Li Q, Shen Y, Zhang H, Liu Y, Li R, Deng H
            and Yang H.
  TITLE     Mitochondrial UQCC3 controls embryonic and tumor angiogenesis by
            regulating VEGF expression
  JOURNAL   iScience 26 (8), 107370 (2023)
   PUBMED   37539028
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 823)
  AUTHORS   Li H, Ko HP and Whitlock JP.
  TITLE     Induction of phosphoglycerate kinase 1 gene expression by hypoxia.
            Roles of Arnt and HIF1alpha
  JOURNAL   J Biol Chem 271 (35), 21262-21267 (1996)
   PUBMED   8702901
REFERENCE   7  (residues 1 to 823)
  AUTHORS   Wood SM, Gleadle JM, Pugh CW, Hankinson O and Ratcliffe PJ.
  TITLE     The role of the aryl hydrocarbon receptor nuclear translocator
            (ARNT) in hypoxic induction of gene expression. Studies in
            ARNT-deficient cells
  JOURNAL   J Biol Chem 271 (25), 15117-15123 (1996)
   PUBMED   8662957
REFERENCE   8  (residues 1 to 823)
  AUTHORS   Semenza GL, Rue EA, Iyer NV, Pang MG and Kearns WG.
  TITLE     Assignment of the hypoxia-inducible factor 1alpha gene to a region
            of conserved synteny on mouse chromosome 12 and human chromosome
            14q
  JOURNAL   Genomics 34 (3), 437-439 (1996)
   PUBMED   8786149
REFERENCE   9  (residues 1 to 823)
  AUTHORS   Wenger RH, Rolfs A, Marti HH, Guenet JL and Gassmann M.
  TITLE     Nucleotide sequence, chromosomal assignment and mRNA expression of
            mouse hypoxia-inducible factor-1 alpha
  JOURNAL   Biochem Biophys Res Commun 223 (1), 54-59 (1996)
   PUBMED   8660378
REFERENCE   10 (residues 1 to 823)
  AUTHORS   Obara N and Takeda M.
  TITLE     Expression of neural cell adhesion molecule (NCAM) during the first
            molar development in the mouse
  JOURNAL   Anat Embryol (Berl) 187 (3), 209-219 (1993)
   PUBMED   8470821
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124712.5.
            
            On Jun 6, 2023 this sequence version replaced XP_006515541.1.
            
            Summary: This gene encodes the alpha subunit which, along with the
            beta subunit, forms a heterodimeric transcription factor that
            regulates the cellular and developmental response to reduced oxygen
            tension. The transcription factor has been shown to regulate genes
            involved in several biological processes, including erythropoiesis
            and angiogenesis which aid in increased delivery of oxygen to
            hypoxic regions. The transcription factor also plays a role in the
            induction of genes involved in cell proliferation and survival,
            energy metabolism, apoptosis, and glucose and iron metabolism.
            Alternative splicing results in multiple transcript variants
            encoding different isoforms. [provided by RefSeq, Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784651.871961.1,
                                           SRR17784646.663546.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..823
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 31.99 cM"
     Protein         1..823
                     /product="hypoxia-inducible factor 1-alpha isoform 5"
                     /note="hypoxia-inducible factor 1-alpha; ARNT-interacting
                     protein"
                     /calculated_mol_wt=91886
     Region          14..84
                     /region_name="bHLH-PAS_HIF1a_PASD8"
                     /note="basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS)
                     domain found in hypoxia-inducible factor 1-alpha (HIF1a)
                     and similar proteins; cd19727"
                     /db_xref="CDD:381570"
     Site            order(19..20,22..24,27..28,30..31,56..57)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381570"
     Region          22..31
                     /region_name="DNA-binding.
                     /evidence=ECO:0000269|PubMed:26245371"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Site            order(33..34,36..37,40..41,44..45,56..58,61..62,65,68..69,
                     72)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:381570"
     Region          94..149
                     /region_name="PAS"
                     /note="PAS domain; smart00091"
                     /db_xref="CDD:214512"
     Region          171..192
                     /region_name="Required for heterodimer formation with
                     ARNT. /evidence=ECO:0000269|PubMed:26245371"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Site            248
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK1.
                     /evidence=ECO:0000250|UniProtKB:Q16665; propagated from
                     UniProtKB/Swiss-Prot (Q61221.3)"
     Region          255..340
                     /region_name="PAS_3"
                     /note="PAS fold; pfam08447"
                     /db_xref="CDD:430001"
     Site            order(256,260,266,279..282,308,313)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:238075"
     Site            order(276,280,288,291..292,320,322)
                     /site_type="other"
                     /note="heme pocket [chemical binding]"
                     /db_xref="CDD:238075"
     Region          381..418
                     /region_name="N-terminal VHL recognition site"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Site            403
                     /site_type="hydroxylation"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:Q16665; propagated from
                     UniProtKB/Swiss-Prot (Q61221.3)"
     Region          493..512
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Region          531..575
                     /region_name="NTAD"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Site            532
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:Q16665; propagated from
                     UniProtKB/Swiss-Prot (Q61221.3)"
     Region          551..580
                     /region_name="HIF-1"
                     /note="Hypoxia-inducible factor-1; pfam11413"
                     /db_xref="CDD:431874"
     Site            551
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by GSK3-beta.
                     /evidence=ECO:0000250|UniProtKB:Q16665; propagated from
                     UniProtKB/Swiss-Prot (Q61221.3)"
     Site            555
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by GSK3-beta.
                     /evidence=ECO:0000250|UniProtKB:Q16665; propagated from
                     UniProtKB/Swiss-Prot (Q61221.3)"
     Region          556..572
                     /region_name="C-terminal VHL recognition site"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Site            564
                     /site_type="hydroxylation"
                     /note="4-hydroxyproline.
                     /evidence=ECO:0000250|UniProtKB:Q16665; propagated from
                     UniProtKB/Swiss-Prot (Q61221.3)"
     Region          576..782
                     /region_name="ID"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Site            576
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PLK3.
                     /evidence=ECO:0000250|UniProtKB:Q16665; propagated from
                     UniProtKB/Swiss-Prot (Q61221.3)"
     Region          580..671
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Site            589
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by GSK3-beta.
                     /evidence=ECO:0000250|UniProtKB:Q16665; propagated from
                     UniProtKB/Swiss-Prot (Q61221.3)"
     Site            655
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PLK3.
                     /evidence=ECO:0000250|UniProtKB:Q16665; propagated from
                     UniProtKB/Swiss-Prot (Q61221.3)"
     Region          694..721
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Site            706
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q16665; propagated from
                     UniProtKB/Swiss-Prot (Q61221.3)"
     Region          715..718
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Region          783..823
                     /region_name="CTAD"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61221.3)"
     Region          786..822
                     /region_name="HIF-1a_CTAD"
                     /note="HIF-1 alpha C terminal transactivation domain;
                     pfam08778"
                     /db_xref="CDD:430212"
     Site            800
                     /site_type="hydroxylation"
                     /note="(3S)-3-hydroxyasparagine.
                     /evidence=ECO:0000250|UniProtKB:Q16665; propagated from
                     UniProtKB/Swiss-Prot (Q61221.3)"
     CDS             1..823
                     /gene="Hif1a"
                     /gene_synonym="bHLHe78; HIF-1-alpha; HIF1-alpha;
                     HIF1alpha; MOP1"
                     /coded_by="NM_001422142.1:290..2761"
                     /note="isoform 5 is encoded by transcript variant 5"
                     /db_xref="GeneID:15251"
                     /db_xref="MGI:MGI:106918"
ORIGIN      
        1 megaggenek knrmsserrk eksrdaarsr rskesevfye lahqlplphn vsshldkasv
       61 mrltisylrv rklldaggld sedemkaqmd cfylkaldgf vmvltddgdm vyisdnvnky
      121 mgltqfeltg hsvfdfthpc dheemremlt hrngpvrkgk elntqrsffl rmkctltsrg
      181 rtmniksatw kvlhctghih vydtnsnqpq cgykkppmtc lvlicepiph psnieiplds
      241 ktflsrhsld mkfsycderi telmgyepee llgrsiyeyy haldsdhltk thhdmftkgq
      301 vttgqyrmla krggyvwvet qatviyntkn sqpqcivcvn yvvsgiiqhd lifslqqtes
      361 vlkpvessdm kmtqlftkve sedtsclfdk lkkepdaltl lapaagdtii sldfgsddte
      421 tedqqledvp lyndvmfpss neklninlam splpssetpk plrssadpal nqevalkles
      481 speslglsft mpqiqdqpas psdgstrqss pepnspseyc fdvdsdmvnv fklelveklf
      541 aedteaknpf stqdtdldle mlapyipmdd dfqlrsfdql splesnspsp psmstvtgfq
      601 qtqlqkptit atatttattd esktetkdnk edikiliasp sstqvpqett takasaysgt
      661 hsrtaspdra gkrvieqtdk ahprslnlsa tlnqrntvpe eelnpktias qnaqrkrkme
      721 hdgslfqaag igtllqqpgd captmslswk rvkgfisseq ngteqktiil ipsdlacrll
      781 gqsmdesglp qltsydcevn apiqgsrnll qgeellrald qvn
//
LOCUS       NP_001013801             354 aa            linear   ROD 09-OCT-2023
DEFINITION  interferon-inducible protein AIM2 [Mus musculus].
ACCESSION   NP_001013801 XP_357160
VERSION     NP_001013801.2
DBSOURCE    REFSEQ: accession NM_001013779.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 354)
  AUTHORS   Sharma BR, Karki R, Rajesh Y and Kanneganti TD.
  TITLE     Immune regulator IRF1 contributes to ZBP1-, AIM2-, RIPK1-, and
            NLRP12-PANoptosome activation and inflammatory cell death
            (PANoptosis)
  JOURNAL   J Biol Chem 299 (9), 105141 (2023)
   PUBMED   37557956
  REMARK    GeneRIF: Immune regulator IRF1 contributes to ZBP1-, AIM2-, RIPK1-,
            and NLRP12-PANoptosome activation and inflammatory cell death
            (PANoptosis).
REFERENCE   2  (residues 1 to 354)
  AUTHORS   Ye L, Shu S, Jia J, Sun M, Xu S, Bao X, Bian H, Liu Y, Zhang M, Zhu
            X, Bai F and Xu Y.
  TITLE     Absent in melanoma 2 mediates aging-related cognitive dysfunction
            by acting on complement-dependent microglial phagocytosis
  JOURNAL   Aging Cell 22 (7), e13860 (2023)
   PUBMED   37177836
  REMARK    GeneRIF: Absent in melanoma 2 mediates aging-related cognitive
            dysfunction by acting on complement-dependent microglial
            phagocytosis.
REFERENCE   3  (residues 1 to 354)
  AUTHORS   Dawson RE, Deswaerte V, West AC, Sun E, Wray-McCann G, Livis T,
            Kumar B, Rodriguez E, Gabay C, Ferrero RL and Jenkins BJ.
  TITLE     The cytosolic DNA sensor AIM2 promotes Helicobacter-induced gastric
            pathology via the inflammasome
  JOURNAL   Immunol Cell Biol 101 (5), 444-457 (2023)
   PUBMED   36967659
  REMARK    GeneRIF: The cytosolic DNA sensor AIM2 promotes
            Helicobacter-induced gastric pathology via the inflammasome.
REFERENCE   4  (residues 1 to 354)
  AUTHORS   Chen Y, Pu J, Li X, Lian L, Ge C, Liu Z, Wang W, Hou L, Chen W and
            Li J.
  TITLE     Aim2 Deficiency Ameliorates Lacrimal Gland Destruction and Corneal
            Epithelium Defects in an Experimental Dry Eye Model
  JOURNAL   Invest Ophthalmol Vis Sci 64 (3), 26 (2023)
   PUBMED   36920364
  REMARK    GeneRIF: Aim2 Deficiency Ameliorates Lacrimal Gland Destruction and
            Corneal Epithelium Defects in an Experimental Dry Eye Model.
REFERENCE   5  (residues 1 to 354)
  AUTHORS   Barclay WE, Aggarwal N, Deerhake ME, Inoue M, Nonaka T, Nozaki K,
            Luzum NA, Miao EA and Shinohara ML.
  TITLE     The AIM2 inflammasome is activated in astrocytes during the late
            phase of EAE
  JOURNAL   JCI Insight 7 (8), e155563 (2022)
   PUBMED   35451371
  REMARK    GeneRIF: The AIM2 inflammasome is activated in astrocytes during
            the late phase of EAE.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 354)
  AUTHORS   Fernandes-Alnemri T, Yu JW, Datta P, Wu J and Alnemri ES.
  TITLE     AIM2 activates the inflammasome and cell death in response to
            cytoplasmic DNA
  JOURNAL   Nature 458 (7237), 509-513 (2009)
   PUBMED   19158676
  REMARK    GeneRIF: identification of AIM2 as an important inflammasome
            component that senses potentially dangerous cytoplasmic DNA,
            leading to activation of the ASC pyroptosome and caspase-1
REFERENCE   7  (residues 1 to 354)
  AUTHORS   Hornung V, Ablasser A, Charrel-Dennis M, Bauernfeind F, Horvath G,
            Caffrey DR, Latz E and Fitzgerald KA.
  TITLE     AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating
            inflammasome with ASC
  JOURNAL   Nature 458 (7237), 514-518 (2009)
   PUBMED   19158675
  REMARK    GeneRIF: observations identify AIM2 as a new receptor for
            cytoplasmic DNA, which forms an inflammasome with the ligand and
            ASC to activate caspase-1
REFERENCE   8  (residues 1 to 354)
  AUTHORS   Roberts TL, Idris A, Dunn JA, Kelly GM, Burnton CM, Hodgson S,
            Hardy LL, Garceau V, Sweet MJ, Ross IL, Hume DA and Stacey KJ.
  TITLE     HIN-200 proteins regulate caspase activation in response to foreign
            cytoplasmic DNA
  JOURNAL   Science 323 (5917), 1057-1060 (2009)
   PUBMED   19131592
  REMARK    GeneRIF: study showed p202 is an inhibitor of DNA-induced caspase
            activation; conversely AIM2 was required for caspase activation by
            cytoplasmic dsDNA; work indicates HIN-200 proteins can act as
            pattern recognition receptors mediating response to cytoplasmic
            dsDNA
REFERENCE   9  (residues 1 to 354)
  AUTHORS   Pritsker M, Doniger TT, Kramer LC, Westcot SE and Lemischka IR.
  TITLE     Diversification of stem cell molecular repertoire by alternative
            splicing
  JOURNAL   Proc Natl Acad Sci U S A 102 (40), 14290-14295 (2005)
   PUBMED   16183747
REFERENCE   10 (residues 1 to 354)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC084073.22, AK050724.1 and DT921984.1.
            
            On Dec 14, 2007 this sequence version replaced NP_001013801.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849375,
                              SAMN00849388 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..354
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 80.33 cM"
     Protein         1..354
                     /product="interferon-inducible protein AIM2"
                     /note="ifi-210; interferon-inducible protein 210;
                     interferon-inducible protein p210"
                     /calculated_mol_wt=40024
     Region          10..79
                     /region_name="Pyrin"
                     /note="a protein-protein interaction domain; cd08305"
                     /db_xref="CDD:260019"
     Region          95..124
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91VJ1.2)"
     Region          156..321
                     /region_name="HIN"
                     /note="HIN-200/IF120x domain; pfam02760"
                     /db_xref="CDD:426966"
     CDS             1..354
                     /gene="Aim2"
                     /gene_synonym="Gm1313; Ifi210"
                     /coded_by="NM_001013779.2:455..1519"
                     /db_xref="CCDS:CCDS15529.2"
                     /db_xref="GeneID:383619"
                     /db_xref="MGI:MGI:2686159"
ORIGIN      
        1 meseyremll ltgldhitee elkrfkyfal tefqiarstl dvadrtelad hliqsagaas
       61 avtkainifq klnymhiana leekkkeaer klmtntkkrg tqkvenrsqa encsaasatr
      121 sdndfkeqaa tevcpqakpq kkqmvaeqea iredlqkdpl vvtvlkainp fecetqegrq
      181 eifhatvate tdfffvkvln aqfkdkfipk rtikisnylw hsnfmevtss svvvdvesnh
      241 evpnnvvkra retprisklk iqpcgtivng lfkvqkitee kdrvlygihd ktgtmevlvl
      301 gnpsktkcee gdkirltffe vskngvkiql ksgpcsffkv ikaakpktdm ksve
//
LOCUS       NP_001349223             508 aa            linear   ROD 09-OCT-2023
DEFINITION  CUGBP Elav-like family member 4 isoform 19 [Mus musculus].
ACCESSION   NP_001349223
VERSION     NP_001349223.1
DBSOURCE    REFSEQ: accession NM_001362294.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 508)
  AUTHORS   Salamon I, Park Y, Miskic T, Kopic J, Matteson P, Page NF, Roque A,
            McAuliffe GW, Favate J, Garcia-Forn M, Shah P, Judas M, Millonig
            JH, Kostovic I, De Rubeis S, Hart RP, Krsnik Z and Rasin MR.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    GeneRIF: Celf4 controls mRNA translation underlying synaptic
            development in the prenatal mammalian neocortex.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 508)
  AUTHORS   Shen Y, Zhang C, Xiao K, Liu D and Xie G.
  TITLE     CELF4 regulates spine formation and depression-like behaviors of
            mice
  JOURNAL   Biochem Biophys Res Commun 605, 39-44 (2022)
   PUBMED   35306363
  REMARK    GeneRIF: CELF4 regulates spine formation and depression-like
            behaviors of mice.
REFERENCE   3  (residues 1 to 508)
  AUTHORS   Moreau MX, Saillour Y, Cwetsch AW, Pierani A and Causeret F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   4  (residues 1 to 508)
  AUTHORS   Li C, Li X, Bi Z, Sugino K, Wang G, Zhu T and Liu Z.
  TITLE     Comprehensive transcriptome analysis of cochlear spiral ganglion
            neurons at multiple ages
  JOURNAL   Elife 9, e50491 (2020)
   PUBMED   31913118
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 508)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 508)
  AUTHORS   Ladd AN, Taffet G, Hartley C, Kearney DL and Cooper TA.
  TITLE     Cardiac tissue-specific repression of CELF activity disrupts
            alternative splicing and causes cardiomyopathy
  JOURNAL   Mol Cell Biol 25 (14), 6267-6278 (2005)
   PUBMED   15988035
  REMARK    GeneRIF: CELF protein activity is required for normal alternative
            splicing in the heart in vivo and normal CELF-mediated alternative
            splicing regulation is in turn required for normal cardiac
            function.
REFERENCE   7  (residues 1 to 508)
  AUTHORS   Meins M, Schlickum S, Wilhelm C, Missbach J, Yadav S, Glaser B,
            Grzmil M, Burfeind P and Laccone F.
  TITLE     Identification and characterization of murine Brunol4, a new member
            of the elav/bruno family
  JOURNAL   Cytogenet Genome Res 97 (3-4), 254-260 (2002)
   PUBMED   12438720
  REMARK    GeneRIF: cloning and characterization
REFERENCE   8  (residues 1 to 508)
  AUTHORS   Ladd AN, Charlet N and Cooper TA.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   9  (residues 1 to 508)
  AUTHORS   Good PJ, Chen Q, Warner SJ and Herring DC.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
REFERENCE   10 (residues 1 to 508)
  AUTHORS   Yulug IG, Egan SE, See CG and Fisher EM.
  TITLE     Mapping GRB2, a signal transduction gene in the human and the mouse
  JOURNAL   Genomics 22 (2), 313-318 (1994)
   PUBMED   7806216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121094.8 and AC144938.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660821.190033.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..508
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 13.92 cM"
     Protein         1..508
                     /product="CUGBP Elav-like family member 4 isoform 19"
                     /note="CUG-BP- and ETR-3-like factor 4; bruno-like protein
                     4; RNA-binding protein BRUNOL-4; bruno-like 4, RNA binding
                     protein"
                     /calculated_mol_wt=53813
     Region          1..298
                     /region_name="Sufficient for RNA-binding and MSE-dependent
                     splicing activity. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          18..39
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          49..135
                     /region_name="RRM1_CELF3_4_5_6"
                     /note="RNA recognition motif 1 (RRM1) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12632"
                     /db_xref="CDD:410041"
     Site            order(55,57,59..60,63,82,84,86,95..97,99,129,131)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410041"
     Region          <56..378
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     Region          121..149
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          151..231
                     /region_name="RRM2_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12635"
                     /db_xref="CDD:410043"
     Site            order(153,155,157..158,161,180,182,184,192..194,196,226,
                     228)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410043"
     Region          239..258
                     /region_name="Necessary for TNNT2 exon 5 inclusion.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     CDS             1..508
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /coded_by="NM_001362294.1:531..2057"
                     /note="isoform 19 is encoded by transcript variant 25"
                     /db_xref="GeneID:108013"
                     /db_xref="MGI:MGI:1932407"
ORIGIN      
        1 myikmatlan gqadnaslst nglgsspgsa ghmnglshsp gnpstipmkd hdaiklfigq
       61 iprnldekdl kplfeefgki yeltvlkdrf tgmhkgcafl tyceresalk aqsalheqkt
      121 lpgmnrpiqv kpadsesrgg ssclrqppsq drklfvgmln kqqseddvrr lfeafgniee
      181 ctilrgpdgn skgcafvkys shaeaqaain alhgsqtmpg assslvvkfa dtdkertmrr
      241 mqqmagqmgm fnpmaipfga ygayaqalmq qqaalmasva qggylnpmaa faaaqmqqma
      301 alnmnglaaa pmtptsggst ppgitapavp sipspigvng ftglppqang qpaaeavfan
      361 gihpypaqsp taadplqqay agvqqyagpa aypaaygqis qafpqpppmi pqqqregrhp
      421 vpsrcqapsc qggqcaisss arrlrelrqp gqrtdrhpgh erlpdrheea qgaaeaaqrr
      481 qspvlsaggs vprgrpglaq grmlnglh
//
LOCUS       NP_766481                711 aa            linear   ROD 09-OCT-2023
DEFINITION  protein mono-ADP-ribosyltransferase PARP12 [Mus musculus].
ACCESSION   NP_766481
VERSION     NP_766481.2
DBSOURCE    REFSEQ: accession NM_172893.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 711)
  AUTHORS   Kerr CM, Parthasarathy S, Schwarting N, O'Connor JJ, Pfannenstiel
            JJ, Giri E, More S, Orozco RC and Fehr AR.
  TITLE     PARP12 is required to repress the replication of a Mac1 mutant
            coronavirus in a cell- and tissue-specific manner
  JOURNAL   J Virol 97 (9), e0088523 (2023)
   PUBMED   37695054
  REMARK    GeneRIF: PARP12 is required to repress the replication of a Mac1
            mutant coronavirus in a cell- and tissue-specific manner.
REFERENCE   2  (residues 1 to 711)
  AUTHORS   Cao G, Guo R, Chen M, Sun C and Wang J.
  TITLE     PARP12 regulates mouse oocyte meiotic maturation
  JOURNAL   J Cell Physiol 238 (7), 1580-1591 (2023)
   PUBMED   37305966
  REMARK    GeneRIF: PARP12 regulates mouse oocyte meiotic maturation.
REFERENCE   3  (residues 1 to 711)
  AUTHORS   Li L, Zhao H, Liu P, Li C, Quanquin N, Ji X, Sun N, Du P, Qin CF,
            Lu N and Cheng G.
  TITLE     PARP12 suppresses Zika virus infection through PARP-dependent
            degradation of NS1 and NS3 viral proteins
  JOURNAL   Sci Signal 11 (535) (2018)
   PUBMED   29921658
  REMARK    GeneRIF: To screen for antiviral IFN-stimulated genes that
            restricted Zika virus replication, and identified PARP12 as a
            strong inhibitor of Zika virus replication. Findings suggest that
            PARP12 mediated the ADP-ribosylation of NS1 and NS3, nonstructural
            viral proteins that are involved in viral replication and
            modulating host defense responses.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 711)
  AUTHORS   Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK,
            Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L,
            Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre
            JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A,
            Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ,
            Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall
            S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA,
            Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR,
            Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana
            S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, MacArthur DG,
            Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC,
            Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL,
            de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown
            SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bucan M and Murray
            SA.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. PMID: 29144450]
REFERENCE   5  (residues 1 to 711)
  AUTHORS   Welsby I, Hutin D, Gueydan C, Kruys V, Rongvaux A and Leo O.
  TITLE     PARP12, an interferon-stimulated gene involved in the control of
            protein translation and inflammation
  JOURNAL   J Biol Chem 289 (38), 26642-26657 (2014)
   PUBMED   25086041
  REMARK    GeneRIF: PARP12 is an interferon-induced gene with a potential role
            in cellular defenses against viral infections.
REFERENCE   6  (residues 1 to 711)
  AUTHORS   Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H,
            Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T,
            Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P,
            Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ,
            Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD,
            Flicek P, Skarnes WC, Mallon AM and Parkinson H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (residues 1 to 711)
  AUTHORS   Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND and Robson P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   8  (residues 1 to 711)
  AUTHORS   Bailey PJ, Klos JM, Andersson E, Karlen M, Kallstrom M, Ponjavic J,
            Muhr J, Lenhard B, Sandelin A and Ericson J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   9  (residues 1 to 711)
  AUTHORS   Katoh M and Katoh M.
  TITLE     Identification and characterization of human TIPARP gene within the
            CCNL amplicon at human chromosome 3q25.31
  JOURNAL   Int J Oncol 23 (2), 541-547 (2003)
   PUBMED   12851707
REFERENCE   10 (residues 1 to 711)
  AUTHORS   Piao Y, Ko NT, Lim MK and Ko MS.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK036886.1, BC120733.1 and BC048927.1.
            
            On Apr 1, 2008 this sequence version replaced NP_766481.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036886.1, AK156623.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..711
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 17.85 cM"
     Protein         1..711
                     /product="protein mono-ADP-ribosyltransferase PARP12"
                     /EC_number="2.4.2.30"
                     /note="zinc finger CCCH type domain containing 1; poly
                     ADP-ribose polymerase 12; poly [ADP-ribose] polymerase 12;
                     zinc finger CCCH domain-containing protein 1;
                     ADP-ribosyltransferase diphtheria toxin-like 12"
                     /calculated_mol_wt=79786
     Region          186..208
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     Region          247..279
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BZ20.3)"
     Site            268
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8BZ20.3)"
     Region          309..382
                     /region_name="WWE"
                     /note="WWE domain; cl02729"
                     /db_xref="CDD:445899"
     Region          387..468
                     /region_name="WWE"
                     /note="WWE domain; pfam02825"
                     /db_xref="CDD:427006"
     Region          571..687
                     /region_name="TCCD_inducible_PARP_like"
                     /note="Poly(ADP-ribose) polymerases catalyse the covalent
                     attachment of ADP-ribose units from NAD+ to itself and to
                     a limited number of other DNA binding proteins, which
                     decreases their affinity for DNA. Poly(ADP-ribose)
                     polymerase is a regulatory component...; cd01439"
                     /db_xref="CDD:238719"
     Site            order(573..577,580,584,588..590,592,605..607,617,670)
                     /site_type="other"
                     /note="nad+ binding pocket [chemical binding]"
                     /db_xref="CDD:238719"
     CDS             1..711
                     /gene="Parp12"
                     /gene_synonym="9930021O16; ARTD12; PARP-12; Zc3hdc1"
                     /coded_by="NM_172893.3:191..2326"
                     /db_xref="CCDS:CCDS20019.1"
                     /db_xref="GeneID:243771"
                     /db_xref="MGI:MGI:2143990"
ORIGIN      
        1 maqaavavae vtqllcaagg alelaelrrr lrtslgtdal erllrdcgrf vvasravvav
       61 gagreaaaaa serlvlavss lrlcrahqgp kpgctglcaq lhlckfliyg nckflktgkn
      121 crnghnlktd hnlsvlrthg vdhltytelc qlllqndpsl lpdiclhynk gdgpfgscsf
      181 qkqciklhic qyflqgeckf gtsckrshef tnsesleqle rlglssdlvs rllstyrnay
      241 diknkgsals kvspspagpq gsserkdssg pvspgtpsqe eseqiclyhi rkscsfqekc
      301 hrvhfhlpyr wqfldggkwk dldnmeliee aysnpskdri vytesaagfh fdnldfnsmk
      361 fgntlarrls tassvtkpph filttdwiwy wmdefgswqe ygrqgsghpv ttisssdver
      421 aylafcapga daqaatlkfq agkhnyelhf kaflqknlvy gtirkvcrrp kyvspqdvqm
      481 kqscntklhg pksipdywdp aalpdlgfkk itlsssseey qkvwnifnrt lpfyfvqkie
      541 riqnmglwev yqwqkcqmqk qnggkevder qlfhgtsanf vdaicqqnfd wrvcglhgts
      601 ygkgsyfard aayshhysks dthshmmfla rvlvgdfvrg stsfvrppak egqsnafyds
      661 cvnsmsdpti fvvfekhqvy peyliqysts skppaspsif valgnlftsr q
//
LOCUS       NP_444352                175 aa            linear   ROD 09-OCT-2023
DEFINITION  mitochondrial inner membrane protease subunit 2 [Mus musculus].
ACCESSION   NP_444352
VERSION     NP_444352.2
DBSOURCE    REFSEQ: accession NM_053122.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 175)
  AUTHORS   Lawther AJ, Zieba J, Fang Z, Furlong TM, Conn I, Govindaraju H,
            Choong LLY, Turner N, Siddiqui KS, Bridge W, Merlin S, Hyams TC,
            Killingsworth M, Eapen V, Clarke RA and Walker AK.
  TITLE     Antioxidant Behavioural Phenotype in the Immp2l Gene Knock-Out
            Mouse
  JOURNAL   Genes (Basel) 14 (9), 1717 (2023)
   PUBMED   37761857
  REMARK    GeneRIF: Antioxidant Behavioural Phenotype in the Immp2l Gene
            Knock-Out Mouse.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 175)
  AUTHORS   Leung BK, Merlin S, Walker AK, Lawther AJ, Paxinos G, Eapen V,
            Clarke R, Balleine BW and Furlong TM.
  TITLE     Immp2l knockdown in male mice increases stimulus-driven
            instrumental behaviour but does not alter goal-directed learning or
            neuron density in cortico-striatal circuits in a model of Tourette
            syndrome and autism spectrum disorder
  JOURNAL   Behav Brain Res 452, 114610 (2023)
   PUBMED   37541448
  REMARK    GeneRIF: Immp2l knockdown in male mice increases stimulus-driven
            instrumental behaviour but does not alter goal-directed learning or
            neuron density in cortico-striatal circuits in a model of Tourette
            syndrome and autism spectrum disorder.
REFERENCE   3  (residues 1 to 175)
  AUTHORS   Ma Y, Liang RM, Ma N, Mi XJ, Cheng ZY, Zhang ZJ, Lu BS and Li PA.
  TITLE     Immp2l Mutation Induces Mitochondrial Membrane Depolarization and
            Complex III Activity Suppression after Middle Cerebral Artery
            Occlusion in Mice
  JOURNAL   Curr Med Sci 43 (3), 478-488 (2023)
   PUBMED   37243806
  REMARK    GeneRIF: Immp2l Mutation Induces Mitochondrial Membrane
            Depolarization and Complex III Activity Suppression after Middle
            Cerebral Artery Occlusion in Mice.
REFERENCE   4  (residues 1 to 175)
  AUTHORS   Regue L, Wang W, Ji F, Avruch J, Wang H and Dai N.
  TITLE     Human T2D-Associated Gene IMP2/IGF2BP2 Promotes the Commitment of
            Mesenchymal Stem Cells Into Adipogenic Lineage
  JOURNAL   Diabetes 72 (1), 33-44 (2023)
   PUBMED   36219823
  REMARK    GeneRIF: Human T2D-Associated Gene IMP2/IGF2BP2 Promotes the
            Commitment of Mesenchymal Stem Cells Into Adipogenic Lineage.
REFERENCE   5  (residues 1 to 175)
  AUTHORS   Peng T, Liu M, Hu L, Guo D, Wang D, Qi B, Ren G, Hu C, Zhang F,
            Chun HJ, Song L, Hu J and Li Y.
  TITLE     LncRNA Airn alleviates diabetic cardiac fibrosis by inhibiting
            activation of cardiac fibroblasts via a m6A-IMP2-p53 axis
  JOURNAL   Biol Direct 17 (1), 32 (2022)
   PUBMED   36384975
  REMARK    GeneRIF: LncRNA Airn alleviates diabetic cardiac fibrosis by
            inhibiting activation of cardiac fibroblasts via a m6A-IMP2-p53
            axis.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 175)
  AUTHORS   Qian J, Dong Y, Pang YY, Ibrahim R, Berzofsky JA, Schiller JT and
            Khleif SN.
  TITLE     Combined prophylactic and therapeutic cancer vaccine: enhancing CTL
            responses to HPV16 E2 using a chimeric VLP in HLA-A2 mice
  JOURNAL   Int J Cancer 118 (12), 3022-3029 (2006)
   PUBMED   16425257
REFERENCE   7  (residues 1 to 175)
  AUTHORS   Burri L, Strahm Y, Hawkins CJ, Gentle IE, Puryer MA, Verhagen A,
            Callus B, Vaux D and Lithgow T.
  TITLE     Mature DIABLO/Smac is produced by the IMP protease complex on the
            mitochondrial inner membrane
  JOURNAL   Mol Biol Cell 16 (6), 2926-2933 (2005)
   PUBMED   15814844
REFERENCE   8  (residues 1 to 175)
  AUTHORS   Petek E, Windpassinger C, Vincent JB, Cheung J, Boright AP, Scherer
            SW, Kroisel PM and Wagner K.
  TITLE     Disruption of a novel gene (IMMP2L) by a breakpoint in 7q31
            associated with Tourette syndrome
  JOURNAL   Am J Hum Genet 68 (4), 848-858 (2001)
   PUBMED   11254443
REFERENCE   9  (residues 1 to 175)
  AUTHORS   Colella TA, Bullock TN, Russell LB, Mullins DW, Overwijk WW, Luckey
            CJ, Pierce RA, Restifo NP and Engelhard VH.
  TITLE     Self-tolerance to the murine homologue of a tyrosinase-derived
            melanoma antigen: implications for tumor immunotherapy
  JOURNAL   J Exp Med 191 (7), 1221-1232 (2000)
   PUBMED   10748239
REFERENCE   10 (residues 1 to 175)
  AUTHORS   Newberg MH, Smith DH, Haertel SB, Vining DR, Lacy E and Engelhard
            VH.
  TITLE     Importance of MHC class 1 alpha2 and alpha3 domains in the
            recognition of self and non-self MHC molecules
  JOURNAL   J Immunol 156 (7), 2473-2480 (1996)
   PUBMED   8786307
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153793.4, AC240395.3, AC124826.8 and AC123620.14.
            
            On Jun 19, 2003 this sequence version replaced NP_444352.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061049.1, CB596676.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..175
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 18.69 cM"
     Protein         1..175
                     /product="mitochondrial inner membrane protease subunit 2"
                     /note="IMP2-like protein; AAD mice"
                     /calculated_mol_wt=19470
     Site            19..37
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BPT6.1)"
     Region          36..146
                     /region_name="S26_SPase_I"
                     /note="The S26 Type I signal peptidase (SPase; LepB;
                     leader peptidase B; leader peptidase I; EC 3.4.21.89)
                     family members are essential membrane-bound serine
                     proteases that function to cleave the amino-terminal
                     signal peptide extension from proteins that are...;
                     cd06530"
                     /db_xref="CDD:119398"
     Site            order(43,91)
                     /site_type="active"
                     /note="Catalytic site [active]"
                     /db_xref="CDD:119398"
     CDS             1..175
                     /gene="Immp2l"
                     /gene_synonym="IMP2; Tg(HLA-A/H2-D)2Enge"
                     /coded_by="NM_053122.5:132..659"
                     /db_xref="CCDS:CCDS83961.1"
                     /db_xref="GeneID:93757"
                     /db_xref="MGI:MGI:2135611"
ORIGIN      
        1 maqsqswarr cfkafckgff vavpvavtfl drvacvarve gssmqpslnp ggsqssdvvl
       61 lnhwkvrnfe vqrgdivslv spknpeqkii krvialegdi vrtighknrl vkvprghmwv
      121 egdhhghsfd snsfgpvslg llhahathil wpperwqrle svlppercpl qtgek
//
LOCUS       NP_001396831             147 aa            linear   ROD 09-OCT-2023
DEFINITION  allograft inflammatory factor 1 isoform a [Mus musculus].
ACCESSION   NP_001396831
VERSION     NP_001396831.1
DBSOURCE    REFSEQ: accession NM_001409902.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 147)
  AUTHORS   Altounian M, Bellon A and Mann F.
  TITLE     Neuronal miR-17-5p contributes to interhemispheric cortical
            connectivity defects induced by prenatal alcohol exposure
  JOURNAL   Cell Rep 42 (9), 113020 (2023)
   PUBMED   37610874
REFERENCE   2  (residues 1 to 147)
  AUTHORS   Rodriguez-Lopez A, Torres-Paniagua AM, Acero G, Diaz G and
            Gevorkian G.
  TITLE     Increased TSPO expression, pyroglutamate-modified amyloid beta
            (AbetaN3(pE)) accumulation and transient clustering of microglia in
            the thalamus of Tg-SwDI mice
  JOURNAL   J Neuroimmunol 382, 578150 (2023)
   PUBMED   37467699
  REMARK    GeneRIF: Increased TSPO expression, pyroglutamate-modified amyloid
            beta (AbetaN3(pE)) accumulation and transient clustering of
            microglia in the thalamus of Tg-SwDI mice.
REFERENCE   3  (residues 1 to 147)
  AUTHORS   Cao B, Xia Y, Cai Z, Wang Z, Tang C and Song Y.
  TITLE     Construction of a Brain-specific SLC23A2 Gene Knockout Mice Model
  JOURNAL   Neuroscience 524, 137-148 (2023)
   PUBMED   37330196
REFERENCE   4  (residues 1 to 147)
  AUTHORS   Meng H, Zhao Y, Li Y, Fan H, Yi X, Meng X, Wang P, Fu F, Wu S and
            Wang Y.
  TITLE     Evidence for developmental vascular-associated necroptosis and its
            contribution to venous-lymphatic endothelial differentiation
  JOURNAL   Front Cell Dev Biol 11, 1229788 (2023)
   PUBMED   37576598
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 147)
  AUTHORS   Waldhauser V, Baroti T, Frob F and Wegner M.
  TITLE     PBAF Subunit Pbrm1 Selectively Influences the Transition from
            Progenitors to Pre-Myelinating Cells during Oligodendrocyte
            Development
  JOURNAL   Cells 12 (12), 1556 (2023)
   PUBMED   37371026
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 147)
  AUTHORS   Sasaki Y, Ohsawa K, Kanazawa H, Kohsaka S and Imai Y.
  TITLE     Iba1 is an actin-cross-linking protein in macrophages/microglia
  JOURNAL   Biochem Biophys Res Commun 286 (2), 292-297 (2001)
   PUBMED   11500035
REFERENCE   7  (residues 1 to 147)
  AUTHORS   Ohsawa K, Imai Y, Kanazawa H, Sasaki Y and Kohsaka S.
  TITLE     Involvement of Iba1 in membrane ruffling and phagocytosis of
            macrophages/microglia
  JOURNAL   J Cell Sci 113 (Pt 17), 3073-3084 (2000)
   PUBMED   10934045
REFERENCE   8  (residues 1 to 147)
  AUTHORS   Allcock RJ, Martin AM and Price P.
  TITLE     The mouse as a model for the effects of MHC genes on human disease
  JOURNAL   Immunol Today 21 (7), 328-332 (2000)
   PUBMED   10871872
  REMARK    Review article
REFERENCE   9  (residues 1 to 147)
  AUTHORS   Handel-Fernandez ME, Kurimoto I, Streilein JW and Vincek V.
  TITLE     Genetic mapping and physical cloning of UVB susceptibility region
            in mice
  JOURNAL   J Invest Dermatol 113 (2), 224-229 (1999)
   PUBMED   10469308
REFERENCE   10 (residues 1 to 147)
  AUTHORS   Lund T, Shaikh S, Kendall E, Campbell RD, Hattori M, Makino S and
            Cooke A.
  TITLE     RFLP analysis of the MHC class III region defines unique haplotypes
            for the non-obese diabetic, cataract Shionogi and the non-obese
            non-diabetic mouse strains
  JOURNAL   Diabetologia 36 (8), 727-733 (1993)
   PUBMED   8104833
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CR974444.18.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021539.1, BI685218.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..147
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.59 cM"
     Protein         1..147
                     /product="allograft inflammatory factor 1 isoform a"
                     /note="testis specific; ionized calcium binding adapter
                     molecule 1"
                     /calculated_mol_wt=16779
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylserine.
                     /evidence=ECO:0000250|UniProtKB:P81076; propagated from
                     UniProtKB/Swiss-Prot (O70200.1)"
     Site            11
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P55008; propagated from
                     UniProtKB/Swiss-Prot (O70200.1)"
     Region          <48..113
                     /region_name="PTZ00184"
                     /note="calmodulin; Provisional"
                     /db_xref="CDD:185504"
     Region          128..147
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O70200.1)"
     CDS             1..147
                     /gene="Aif1"
                     /gene_synonym="AIF-1; D17H6S50E; G1; Iba1"
                     /coded_by="NM_001409902.1:91..534"
                     /note="isoform a is encoded by transcript variant 5"
                     /db_xref="GeneID:11629"
                     /db_xref="MGI:MGI:1343098"
ORIGIN      
        1 msqsrdlqgg kafgllkaqq eerleginkq flddpkysnd edlpskleaf kvkymefdln
       61 gngdidimsl krmleklgvp kthlelkrli revssgseet fsysdflrmm lgkrsailrm
      121 ilmyeeknke hkrptgppak kaiselp
//
LOCUS       NP_033309                749 aa            linear   ROD 09-OCT-2023
DEFINITION  signal transducer and activator of transcription 1 isoform 2 [Mus
            musculus].
ACCESSION   NP_033309
VERSION     NP_033309.3
DBSOURCE    REFSEQ: accession NM_009283.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 749)
  AUTHORS   Kong P, Yang M, Wang Y, Yu KN, Wu L and Han W.
  TITLE     Ferroptosis triggered by STAT1- IRF1-ACSL4 pathway was involved in
            radiation-induced intestinal injury
  JOURNAL   Redox Biol 66, 102857 (2023)
   PUBMED   37611494
  REMARK    GeneRIF: Ferroptosis triggered by STAT1- IRF1-ACSL4 pathway was
            involved in radiation-induced intestinal injury.
REFERENCE   2  (residues 1 to 749)
  AUTHORS   Clark DN, O'Neil SM, Xu L, Steppe JT, Savage JT, Raghunathan K and
            Filiano AJ.
  TITLE     Prolonged STAT1 activation in neurons drives a pathological
            transcriptional response
  JOURNAL   J Neuroimmunol 382, 578168 (2023)
   PUBMED   37556887
  REMARK    GeneRIF: Prolonged STAT1 activation in neurons drives a
            pathological transcriptional response.
REFERENCE   3  (residues 1 to 749)
  AUTHORS   Imitola J, Hollingsworth EW, Watanabe F, Olah M, Elyaman W,
            Starossom S, Kivisakk P and Khoury SJ.
  TITLE     Stat1 is an inducible transcriptional repressor of neural stem
            cells self-renewal program during neuroinflammation
  JOURNAL   Front Cell Neurosci 17, 1156802 (2023)
   PUBMED   37663126
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 749)
  AUTHORS   Han W, Pu H, Li S, Liu Y, Zhao Y, Xu M, Chen C, Wu Y, Yang T, Ye Q,
            Wang H, Stetler RA, Chen J and Shi Y.
  TITLE     Targeted ablation of signal transducer and activator of
            transduction 1 alleviates inflammation by microglia/macrophages and
            promotes long-term recovery after ischemic stroke
  JOURNAL   J Neuroinflammation 20 (1), 178 (2023)
   PUBMED   37516843
  REMARK    GeneRIF: Targeted ablation of signal transducer and activator of
            transduction 1 alleviates inflammation by microglia/macrophages and
            promotes long-term recovery after ischemic stroke.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 749)
  AUTHORS   Largent AD, Lambert K, Chiang K, Shumlak N, Liggitt D, Oukka M,
            Torgerson TR, Buckner JH, Allenspach EJ, Rawlings DJ and Jackson
            SW.
  TITLE     Dysregulated IFN-gamma signals promote autoimmunity in STAT1
            gain-of-function syndrome
  JOURNAL   Sci Transl Med 15 (703), eade7028 (2023)
   PUBMED   37406138
REFERENCE   6  (residues 1 to 749)
  AUTHORS   Novak U, Harpur AG, Paradiso L, Kanagasundaram V, Jaworowski A,
            Wilks AF and Hamilton JA.
  TITLE     Colony-stimulating factor 1-induced STAT1 and STAT3 activation is
            accompanied by phosphorylation of Tyk2 in macrophages and Tyk2 and
            JAK1 in fibroblasts
  JOURNAL   Blood 86 (8), 2948-2956 (1995)
   PUBMED   7579387
REFERENCE   7  (residues 1 to 749)
  AUTHORS   Finidori J and Kelly PA.
  TITLE     Cytokine receptor signalling through two novel families of
            transducer molecules: Janus kinases, and signal transducers and
            activators of transcription
  JOURNAL   J Endocrinol 147 (1), 11-23 (1995)
   PUBMED   7490523
  REMARK    Review article
REFERENCE   8  (residues 1 to 749)
  AUTHORS   Harroch S, Gothelf Y, Revel M and Chebath J.
  TITLE     5' upstream sequences of MyD88, an IL-6 primary response gene in M1
            cells: detection of functional IRF-1 and Stat factors binding sites
  JOURNAL   Nucleic Acids Res 23 (17), 3539-3546 (1995)
   PUBMED   7567467
REFERENCE   9  (residues 1 to 749)
  AUTHORS   Matsuda T and Hirano T.
  TITLE     Association of p72 tyrosine kinase with Stat factors and its
            activation by interleukin-3, interleukin-6, and granulocyte
            colony-stimulating factor
  JOURNAL   Blood 83 (12), 3457-3461 (1994)
   PUBMED   7515712
REFERENCE   10 (residues 1 to 749)
  AUTHORS   Zhong Z, Wen Z and Darnell JE Jr.
  TITLE     Stat3 and Stat4: members of the family of signal transducers and
            activators of transcription
  JOURNAL   Proc Natl Acad Sci U S A 91 (11), 4806-4810 (1994)
   PUBMED   7545930
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK039458.1, AK082706.1, AC123752.8, BC042551.1 and BX513160.1.
            
            On Sep 14, 2006 this sequence version replaced NP_033309.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and uses
            an alternate in-frame splice site in the 3' coding region, compared
            to variant 1. This results in a shorter protein (isoform 2),
            compared to isoform 1. Variants 2, 3, and 4 encode the same
            isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK082706.1, AK159887.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..749
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 26.81 cM"
     Protein         1..749
                     /product="signal transducer and activator of transcription
                     1 isoform 2"
                     /calculated_mol_wt=87184
     Region          2..121
                     /region_name="STAT_int"
                     /note="STAT protein, protein interaction domain;
                     smart00964"
                     /db_xref="CDD:214942"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylserine.
                     /evidence=ECO:0000250|UniProtKB:P42224; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     Site            114
                     /site_type="methylation"
                     /note="N6-methyllysine.
                     /evidence=ECO:0000250|UniProtKB:P42224; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     Region          138..313
                     /region_name="STAT1_CCD"
                     /note="Coiled-coil domain of Signal Transducer and
                     Activator of Transcription 1 (STAT1); cd16851"
                     /db_xref="CDD:341076"
     Site            order(164..165,168..169,172,175..176,179,232,236,239..241,
                     243..244,256..257,259..260,263..264,267,271,274,306,
                     309..311)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:341076"
     Site            175
                     /site_type="methylation"
                     /note="N6-methyllysine.
                     /evidence=ECO:0000250|UniProtKB:P42224; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     Site            order(239..241,243..244,256..257,260,263..264,267,271,274,
                     302,306,309..310)
                     /site_type="other"
                     /note="CCD-DBD interface [polypeptide binding]"
                     /db_xref="CDD:341076"
     Site            296
                     /site_type="methylation"
                     /note="N6-methyllysine.
                     /evidence=ECO:0000250|UniProtKB:P42224; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     Region          317..477
                     /region_name="STAT1_DBD"
                     /note="DNA-binding domain of Signal Transducer and
                     Activator of Transcription 1 (STAT1); cd16845"
                     /db_xref="CDD:341083"
     Site            order(336,340,378,411,413,426..427,459..460,463)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:341083"
     Site            366
                     /site_type="methylation"
                     /note="N6-methyllysine.
                     /evidence=ECO:0000250|UniProtKB:P42224; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     Site            525
                     /site_type="methylation"
                     /note="N6-methyllysine.
                     /evidence=ECO:0000250|UniProtKB:P42224; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     Region          557..707
                     /region_name="SH2_STAT1"
                     /note="Src homology 2 (SH2) domain found in signal
                     transducer and activator of transcription (STAT) 1
                     proteins; cd10372"
                     /db_xref="CDD:198235"
     Site            order(584,602,630,632)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198235"
     Site            order(631,647)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198235"
     Site            637
                     /site_type="methylation"
                     /note="N6-methyllysine.
                     /evidence=ECO:0000250|UniProtKB:P42224; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     Site            order(641..642,706)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:198235"
     Site            665
                     /site_type="methylation"
                     /note="N6-methyllysine.
                     /evidence=ECO:0000250|UniProtKB:P42224; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     Site            701
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by JAK1, JAK2 or TYK2.
                     /evidence=ECO:0000269|PubMed:19088846,
                     ECO:0000269|PubMed:22065572; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     Site            708
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by IKKE.
                     /evidence=ECO:0000269|PubMed:17332413,
                     ECO:0000269|PubMed:22065572; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     Region          715..739
                     /region_name="STAT1_TAZ2bind"
                     /note="STAT1 TAZ2 binding domain; pfam12162"
                     /db_xref="CDD:432372"
     Site            724
                     /site_type="other"
                     /note="Required for recruitment of EP300/p300.
                     /evidence=ECO:0000250|UniProtKB:P42224; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     Site            727
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CaMK2 and MAPK14.
                     /evidence=ECO:0000269|PubMed:11972023,
                     ECO:0000269|PubMed:22065572; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     Site            744
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by IKKE.
                     /evidence=ECO:0000305|PubMed:17332413; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     CDS             1..749
                     /gene="Stat1"
                     /gene_synonym="2010005J02Rik"
                     /coded_by="NM_009283.4:351..2600"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS56628.1"
                     /db_xref="GeneID:20846"
                     /db_xref="MGI:MGI:103063"
ORIGIN      
        1 msqwfelqql dskfleqvhq lyddsfpmei rqylaqwlek qdwehaaydv sfatirfhdl
       61 lsqlddqysr fslennfllq hnirkskrnl qdnfqedpvq msmiiynclk eerkilenaq
      121 rfnqaqegni qntvmldkqk eldskvrnvk dqvmcieqei ktleelqdey dfkcktsqnr
      181 egeangvaks dqkqeqlllh kmflmldnkr keiihkirel lnsieltqnt lindelvewk
      241 rrqqsacigg ppnacldqlq swftivaetl qqirqqlkkl eeleqkftye pdpitknkqv
      301 lsdrtfllfq qliqssfvve rqpcmpthpq rplvlktgvq ftvklrllvk lqelnynlkv
      361 kvsfdkdvne kntvkgfrkf nilgthtkvm nmeestngsl aaefrhlqlk eqknagnrtn
      421 egplivteel hslsfetqlc qpglvidlet tslpvvvisn vsqlpsgwas ilwynmlvte
      481 prnlsfflnp pcawwsqlse vlswqfssvt krglnadqls mlgekllgpn agpdglipwt
      541 rfckenindk nfsfwpwidt ilelikkhll clwndgcimg fiskereral lkdqqpgtfl
      601 lrfsessreg aitftwvers qnggepdfha vepytkkels avtfpdiirn ykvmaaenip
      661 enplkylypn idkdhafgky ysrpkeapep melddpkrtg yiktelisvs evhpsrlqtt
      721 dnllpmspee fdemsrivgp efdsmmstv
//
LOCUS       NP_001305031             478 aa            linear   ROD 09-OCT-2023
DEFINITION  mitogen-activated protein kinase 10 isoform 1x [Mus musculus].
ACCESSION   NP_001305031
VERSION     NP_001305031.1
DBSOURCE    REFSEQ: accession NM_001318102.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 478)
  AUTHORS   Priego M, Noriega L, Kalinin S, Hoffman LM, Feinstein DL and
            Morfini G.
  TITLE     Genetic deletion of c-Jun amino-terminal kinase 3 (JNK3) modestly
            increases disease severity in a mouse model of multiple sclerosis
  JOURNAL   J Neuroimmunol 382, 578152 (2023)
   PUBMED   37454525
  REMARK    GeneRIF: Genetic deletion of c-Jun amino-terminal kinase 3 (JNK3)
            modestly increases disease severity in a mouse model of multiple
            sclerosis.
REFERENCE   2  (residues 1 to 478)
  AUTHORS   Liu F, Deng Y, Zhao Y, Li Z, Gao J, Zhang Y, Yang X, Liu Y and Xia
            Y.
  TITLE     Time series RNA-seq analysis identifies MAPK10 as a critical gene
            in diabetes mellitus-induced atrial fibrillation in mice
  JOURNAL   J Mol Cell Cardiol 168, 70-82 (2022)
   PUBMED   35489387
  REMARK    GeneRIF: Time series RNA-seq analysis identifies MAPK10 as a
            critical gene in diabetes mellitus-induced atrial fibrillation in
            mice.
REFERENCE   3  (residues 1 to 478)
  AUTHORS   Cunningham JG, Scripter JD, Nti SA and Tucker ES.
  TITLE     Early construction of the thalamocortical axon pathway requires
            c-Jun N-terminal kinase signaling within the ventral forebrain
  JOURNAL   Dev Dyn 251 (3), 459-480 (2022)
   PUBMED   34494344
REFERENCE   4  (residues 1 to 478)
  AUTHORS   Goodwani S, Fernandez C, Acton PJ, Buggia-Prevot V, McReynolds ML,
            Ma J, Hu CH, Hamby ME, Jiang Y, Le K, Soth MJ, Jones P and Ray WJ.
  TITLE     Dual Leucine Zipper Kinase Is Constitutively Active in the Adult
            Mouse Brain and Has Both Stress-Induced and Homeostatic Functions
  JOURNAL   Int J Mol Sci 21 (14), 4849 (2020)
   PUBMED   32659913
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 478)
  AUTHORS   Loughran G, Chou MY, Ivanov IP, Jungreis I, Kellis M, Kiran AM,
            Baranov PV and Atkins JF.
  TITLE     Evidence of efficient stop codon readthrough in four mammalian
            genes
  JOURNAL   Nucleic Acids Res 42 (14), 8928-8938 (2014)
   PUBMED   25013167
REFERENCE   6  (residues 1 to 478)
  AUTHORS   Beier H and Grimm M.
  TITLE     Misreading of termination codons in eukaryotes by natural nonsense
            suppressor tRNAs
  JOURNAL   Nucleic Acids Res 29 (23), 4767-4782 (2001)
   PUBMED   11726686
  REMARK    Review article
REFERENCE   7  (residues 1 to 478)
  AUTHORS   Yang DD, Kuan CY, Whitmarsh AJ, Rincon M, Zheng TS, Davis RJ, Rakic
            P and Flavell RA.
  TITLE     Absence of excitotoxicity-induced apoptosis in the hippocampus of
            mice lacking the Jnk3 gene
  JOURNAL   Nature 389 (6653), 865-870 (1997)
   PUBMED   9349820
REFERENCE   8  (residues 1 to 478)
  AUTHORS   Casanova E, Garate C, Ovalle S, Calvo P and Chinchetru MA.
  TITLE     Identification of four splice variants of the mouse
            stress-activated protein kinase JNK/SAPK alpha-isoform
  JOURNAL   Neuroreport 7 (7), 1320-1324 (1996)
   PUBMED   8817558
REFERENCE   9  (residues 1 to 478)
  AUTHORS   Martin JH, Mohit AA and Miller CA.
  TITLE     Developmental expression in the mouse nervous system of the p493F12
            SAP kinase
  JOURNAL   Brain Res Mol Brain Res 35 (1-2), 47-57 (1996)
   PUBMED   8717339
REFERENCE   10 (residues 1 to 478)
  AUTHORS   Suzuki J, Yoshida S, Chen ZL, Momota Y, Kato K, Hirata A and
            Shiosaka S.
  TITLE     Ontogeny of neuropsin mRNA expression in the mouse brain
  JOURNAL   Neurosci Res 23 (4), 345-351 (1995)
   PUBMED   8602273
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK082242.1, BC046625.1,
            AC137121.9 and AC125252.7.
            
            Summary: The protein encoded by this gene is a member of the MAP
            kinase family. MAP kinases act as integration points for multiple
            biochemical signals, and thus are involved in a wide variety of
            cellular processes, such as proliferation, differentiation,
            transcription regulation and development. This kinase is
            specifically expressed in a subset of neurons in the nervous system
            and is activated by threonine and tyrosine phosphorylation.
            Targeted deletion of this gene in mice suggests that it may have a
            role in stress-induced neuronal apoptosis. Alternatively spliced
            transcript variants encoding different isoforms have been found for
            this gene. A recent study provided evidence for translational
            readthrough in this gene, and expression of an additional
            C-terminally extended isoform via the use of an alternative
            in-frame translation termination codon. [provided by RefSeq, Dec
            2017].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript and encodes two isoforms, which result from the use of
            alternative in-frame translation termination codons. The shorter
            isoform (1, also know as JNK3 alpha1) results from translation
            termination at the upstream UGA stop codon, while the longer
            isoform (1x) results from UGA stop codon readthrough to the
            downstream UGA termination codon. This RefSeq represents the
            longer, C-terminally extended isoform (1x). As the UGA stop codon
            has been reported to specify several alternative amino acids
            (tryptophan, cysteine, arginine and serine), the location of the
            upstream UGA stop codon in the longer isoform is denoted by an 'X'.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219379.4978.1, BC046625.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            stop codon readthrough :: inferred from conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 49.61 cM"
     Protein         1..478
                     /product="mitogen-activated protein kinase 10 isoform 1x"
                     /EC_number="2.7.11.24"
                     /note="JNK3 beta1 protein kinase; JNK3 beta2 protein
                     kinase; MAP kinase 10; MAP kinase p49 3F12; c-Jun
                     N-terminal kinase 3; stress-activated protein kinase JNK3;
                     SAPK/Erk/kinase 2"
                     /calculated_mol_wt=53904
     Region          63..398
                     /region_name="STKc_JNK"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     c-Jun N-terminal Kinase; cd07850"
                     /db_xref="CDD:270840"
     Site            order(70..76,78,91,93,110,124,146..152,154..155,189,191,
                     193..194,196,206..207,210,221,223..226,228,265)
                     /site_type="active"
                     /db_xref="CDD:270840"
     Site            order(70..76,78,91,93,124,146..152,196,206)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270840"
     Site            order(110,154,189,191,210,221,223..226,228,265)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270840"
     Site            order(150,156,165,168,197..201,361..362,364,367)
                     /site_type="other"
                     /note="KIM docking site [polypeptide binding]"
                     /db_xref="CDD:270840"
     Site            order(206..216,220..228)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270840"
     CDS             1..478
                     /gene="Mapk10"
                     /gene_synonym="C230008H04Rik; JNK3; JNK3B1; JNK3B2;
                     p493F12; p54bSAPK; SAPK(beta); Serk2"
                     /coded_by="NM_001318102.1:567..2003"
                     /note="isoform 1x is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS89959.1"
                     /db_xref="GeneID:26414"
                     /db_xref="MGI:MGI:1346863"
ORIGIN      
        1 mslhflyycs eptldvkiaf cqgfdkhvdv ssiakhynms kskvdnqfys vevgdstftv
       61 lkryqnlkpi gsgaqgivca aydavldrnv aikklsrpfq nqthakrayr elvlmkcvnh
      121 kniisllnvf tpqktleefq dvylvmelmd anlcqviqme ldhermsyll yqmlcgikhl
      181 hsagiihrdl kpsnivvksd ctlkildfgl artagtsfmm tpyvvtryyr apevilgmgy
      241 kenvdiwsvg cimgemvrhk ilfpgrdyid qwnkvieqlg tpcpefmkkl qptvrnyven
      301 rpkyagltfp klfpdslfpa dsehnklkas qardllskml vidpakrisv ddalqhpyin
      361 vwydpaevea pppqiydkql derehtieew keliykevmn seektkngvv kgqpspsgaa
      421 vnsseslpps ssvndissms tdqtlasdtd ssleasagpl gccrxlaacl rnpaffrr
//
LOCUS       NP_083281                464 aa            linear   ROD 09-OCT-2023
DEFINITION  mixed lineage kinase domain-like protein isoform 2 [Mus musculus].
ACCESSION   NP_083281 XP_001003995 XP_001003998 XP_356104 XP_900120 XP_922053
            XP_929682
VERSION     NP_083281.1
DBSOURCE    REFSEQ: accession NM_029005.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 464)
  AUTHORS   Garnish SE, Martin KR, Kauppi M, Jackson VE, Ambrose R, Eng VV,
            Chiou S, Meng Y, Frank D, Tovey Crutchfield EC, Patel KM, Jacobsen
            AV, Atkin-Smith GK, Di Rago L, Doerflinger M, Horne CR, Hall C,
            Young SN, Cook M, Athanasopoulos V, Vinuesa CG, Lawlor KE, Wicks
            IP, Ebert G, Ng AP, Slade CA, Pearson JS, Samson AL, Silke J,
            Murphy JM and Hildebrand JM.
  TITLE     A common human MLKL polymorphism confers resistance to negative
            regulation by phosphorylation
  JOURNAL   Nat Commun 14 (1), 6046 (2023)
   PUBMED   37770424
  REMARK    GeneRIF: A common human MLKL polymorphism confers resistance to
            negative regulation by phosphorylation.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 464)
  AUTHORS   Wang S and Xu M.
  TITLE     RIP3/MLKL regulates necroptosis via activating 4EBP1-eIF4E pathway
  JOURNAL   Zhong Nan Da Xue Xue Bao Yi Xue Ban 48 (7), 979-985 (2023)
   PUBMED   37724400
  REMARK    GeneRIF: RIP3/MLKL regulates necroptosis via activating 4EBP1-eIF4E
            pathway.
REFERENCE   3  (residues 1 to 464)
  AUTHORS   Meng H, Zhao Y, Li Y, Fan H, Yi X, Meng X, Wang P, Fu F, Wu S and
            Wang Y.
  TITLE     Evidence for developmental vascular-associated necroptosis and its
            contribution to venous-lymphatic endothelial differentiation
  JOURNAL   Front Cell Dev Biol 11, 1229788 (2023)
   PUBMED   37576598
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 464)
  AUTHORS   Yan M, Li H, Xu S, Wu J, Li J, Xiao C, Mo C and Ding BS.
  TITLE     Targeting Endothelial Necroptosis Disrupts Profibrotic
            Endothelial-Hepatic Stellate Cells Crosstalk to Alleviate Liver
            Fibrosis in Nonalcoholic Steatohepatitis
  JOURNAL   Int J Mol Sci 24 (14), 11313 (2023)
   PUBMED   37511074
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 464)
  AUTHORS   Vucur M, Ghallab A, Schneider AT, Adili A, Cheng M, Castoldi M,
            Singer MT, Buttner V, Keysberg LS, Kusgens L, Kohlhepp M, Gorg B,
            Gallage S, Barragan Avila JE, Unger K, Kordes C, Leblond AL,
            Albrecht W, Loosen SH, Lohr C, Jordens MS, Babler A, Hayat S,
            Schumacher D, Koenen MT, Govaere O, Boekschoten MV, Jors S,
            Villacorta-Martin C, Mazzaferro V, Llovet JM, Weiskirchen R, Kather
            JN, Starlinger P, Trauner M, Luedde M, Heij LR, Neumann UP, Keitel
            V, Bode JG, Schneider RK, Tacke F, Levkau B, Lammers T, Fluegen G,
            Alexandrov T, Collins AL, Nelson G, Oakley F, Mann DA, Roderburg C,
            Longerich T, Weber A, Villanueva A, Samson AL, Murphy JM, Kramann
            R, Geisler F, Costa IG, Hengstler JG, Heikenwalder M and Luedde T.
  TITLE     Sublethal necroptosis signaling promotes inflammation and liver
            cancer
  JOURNAL   Immunity 56 (7), 1578-1595 (2023)
   PUBMED   37329888
REFERENCE   6  (residues 1 to 464)
  AUTHORS   Wu J, Huang Z, Ren J, Zhang Z, He P, Li Y, Ma J, Chen W, Zhang Y,
            Zhou X, Yang Z, Wu SQ, Chen L and Han J.
  TITLE     Mlkl knockout mice demonstrate the indispensable role of Mlkl in
            necroptosis
  JOURNAL   Cell Res 23 (8), 994-1006 (2013)
   PUBMED   23835476
  REMARK    GeneRIF: Neither Mlkl nor Rip3 deficiency provided protection
            against polymicrobial sepsis-induced animal death in the study of
            septic shock induced by CLP.
REFERENCE   7  (residues 1 to 464)
  AUTHORS   Chen W, Zhou Z, Li L, Zhong CQ, Zheng X, Wu X, Zhang Y, Ma H, Huang
            D, Li W, Xia Z and Han J.
  TITLE     Diverse sequence determinants control human and mouse receptor
            interacting protein 3 (RIP3) and mixed lineage kinase domain-like
            (MLKL) interaction in necroptotic signaling
  JOURNAL   J Biol Chem 288 (23), 16247-16261 (2013)
   PUBMED   23612963
  REMARK    GeneRIF: the importance of the RIP3-MLKL interaction in the
            formation of functional necrosomes and suggest that translocation
            of necrosomes to mitochondria-associated membranes is essential for
            necroptosis signaling.
REFERENCE   8  (residues 1 to 464)
  AUTHORS   Zhao J, Jitkaew S, Cai Z, Choksi S, Li Q, Luo J and Liu ZG.
  TITLE     Mixed lineage kinase domain-like is a key receptor interacting
            protein 3 downstream component of TNF-induced necrosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (14), 5322-5327 (2012)
   PUBMED   22421439
REFERENCE   9  (residues 1 to 464)
  AUTHORS   Sun L, Wang H, Wang Z, He S, Chen S, Liao D, Wang L, Yan J, Liu W,
            Lei X and Wang X.
  TITLE     Mixed lineage kinase domain-like protein mediates necrosis
            signaling downstream of RIP3 kinase
  JOURNAL   Cell 148 (1-2), 213-227 (2012)
   PUBMED   22265413
  REMARK    GeneRIF: Findings implicate MLKL as a key mediator of necrosis
            signaling downstream of the kinase RIP3.
REFERENCE   10 (residues 1 to 464)
  AUTHORS   Bisson N, Tremblay M, Robinson F, Kaplan DR, Trusko SP and Moss T.
  TITLE     Mice lacking both mixed-lineage kinase genes Mlk1 and Mlk2 retain a
            wild type phenotype
  JOURNAL   Cell Cycle 7 (7), 909-916 (2008)
   PUBMED   18414056
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC163625.5, BY740989.1,
            AK018636.1 and BY467591.1.
            
            On or before Jul 24, 2006 this sequence version replaced
            XP_356104.3, XP_900120.1, XP_929682.1, XP_922053.1, XP_001003998.1,
            XP_001003995.1.
            
            Summary: This gene belongs to the protein kinase superfamily. The
            encoded protein contains a protein kinase-like domain; however, is
            thought to lack protein kinase activity. This protein plays a
            critical role in tumor necrosis factor (TNF)-induced necroptosis, a
            programmed cell death process, via interaction with
            receptor-interacting protein 3 (Rip3), which is a key signaling
            molecule in necroptosis pathway. Knockout of this gene in mice
            showed that it is essential for necroptosis. Alternatively spliced
            transcript variants have been found for this gene. [provided by
            RefSeq, Sep 2015].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 3' coding region compared to variant 1. It
            encodes isoform 2, which is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC023755.1, AK170260.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..464
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 57.98 cM"
     Protein         1..464
                     /product="mixed lineage kinase domain-like protein isoform
                     2"
                     /note="mixed lineage kinase domain-like protein"
                     /calculated_mol_wt=53244
     Region          1..143
                     /region_name="N-terminal bundle and brace (NBB), mediates
                     INSP6 binding. /evidence=ECO:0000250|UniProtKB:Q8NB16"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D2Y4.1)"
     Region          5..143
                     /region_name="MLKL_NTD"
                     /note="N-terminal domain of mixed lineage kinase
                     domain-like protein (MLKL) and similar proteins; cd21037"
                     /db_xref="CDD:411030"
     Site            124
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8NB16; propagated from
                     UniProtKB/Swiss-Prot (Q9D2Y4.1)"
     Region          130..>179
                     /region_name="COG7"
                     /note="Golgi complex component 7 (COG7); pfam10191"
                     /db_xref="CDD:431125"
     Region          198..454
                     /region_name="PKc_like"
                     /note="Protein Kinases, catalytic domain; cl21453"
                     /db_xref="CDD:451246"
     Site            345
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by RIPK3.
                     /evidence=ECO:0000269|PubMed:24012422,
                     ECO:0000269|PubMed:24095729; propagated from
                     UniProtKB/Swiss-Prot (Q9D2Y4.1)"
     Site            347
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by RIPK3.
                     /evidence=ECO:0000269|PubMed:24012422,
                     ECO:0000269|PubMed:24095729; propagated from
                     UniProtKB/Swiss-Prot (Q9D2Y4.1)"
     Site            349
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by RIPK3.
                     /evidence=ECO:0000269|PubMed:24012422,
                     ECO:0000269|PubMed:24095729; propagated from
                     UniProtKB/Swiss-Prot (Q9D2Y4.1)"
     Site            352
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by RIPK3.
                     /evidence=ECO:0000269|PubMed:24095729; propagated from
                     UniProtKB/Swiss-Prot (Q9D2Y4.1)"
     CDS             1..464
                     /gene="Mlkl"
                     /gene_synonym="9130019I15Rik"
                     /coded_by="NM_029005.3:385..1779"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS52671.1"
                     /db_xref="GeneID:74568"
                     /db_xref="MGI:MGI:1921818"
ORIGIN      
        1 mdklgqiikl gqliyeqcek mkycrkqcqr lgnrvhgllq plqrlqaqgk knlpdditaa
       61 lgrfdevlke anqqiekfsk kshiwkfvsv gndkilfhev neklrdvwee lllllqvyhw
      121 ntvsdvsqpa swqqedrqda eedgnenmkv ilmqlqisve einktlkqcs lkptqeipqd
      181 lqikeipkeh lgppwtklkt skmstiyrge yhrspvtikv fnnpqaesvg ivrftfndei
      241 ktmkkfdspn ilrifgicid qtvkppefsi vmeycelgtl relldrekdl tmsvrsllvl
      301 raarglyrlh hsetlhrnis sssflvaggy qvklagfels ktqnsisrta kstkaersss
      361 tiyvsperlk npfclydika eiysfgivlw eiatgkipfe gcdskkirel vaedkkqepv
      421 gqdcpellre iinecrahep sqrpsvdgil erlsaveest dkkv
//
LOCUS       NP_001277656             431 aa            linear   ROD 09-OCT-2023
DEFINITION  AT-rich interactive domain-containing protein 5A isoform 6 [Mus
            musculus].
ACCESSION   NP_001277656 XP_006495915
VERSION     NP_001277656.1
DBSOURCE    REFSEQ: accession NM_001290727.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 431)
  AUTHORS   Li X, Hua S, Fang D, Fei X, Tan Z, Zheng F, Wang W and Fang M.
  TITLE     RAGE deficiency ameliorates autoimmune hepatitis involving
            inhibition of IL-6 production via suppressing protein Arid5a in
            mice
  JOURNAL   Clin Exp Med 23 (6), 2167-2179 (2023)
   PUBMED   36454447
  REMARK    GeneRIF: RAGE deficiency ameliorates autoimmune hepatitis involving
            inhibition of IL-6 production via suppressing protein Arid5a in
            mice.
REFERENCE   2  (residues 1 to 431)
  AUTHORS   Taylor TC, Li Y, Li DD, Majumder S, McGeachy MJ, Biswas PS, Gingras
            S and Gaffen SL.
  TITLE     Arid5a Mediates an IL-17-Dependent Pathway That Drives Autoimmunity
            but Not Antifungal Host Defense
  JOURNAL   J Immunol 209 (6), 1138-1145 (2022)
   PUBMED   35940634
  REMARK    GeneRIF: Arid5a Mediates an IL-17-Dependent Pathway That Drives
            Autoimmunity but Not Antifungal Host Defense.
REFERENCE   3  (residues 1 to 431)
  AUTHORS   Catela C, Chen Y, Weng Y, Wen K and Kratsios P.
  TITLE     Control of spinal motor neuron terminal differentiation through
            sustained Hoxc8 gene activity
  JOURNAL   Elife 11, e70766 (2022)
   PUBMED   35315772
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 431)
  AUTHORS   Nyati KK, Hashimoto S, Singh SK, Tekguc M, Metwally H, Liu YC,
            Okuzaki D, Gemechu Y, Kang S and Kishimoto T.
  TITLE     The novel long noncoding RNA AU021063, induced by IL-6/Arid5a
            signaling, exacerbates breast cancer invasion and metastasis by
            stabilizing Trib3 and activating the Mek/Erk pathway
  JOURNAL   Cancer Lett 520, 295-306 (2021)
   PUBMED   34389433
  REMARK    GeneRIF: The novel long noncoding RNA AU021063, induced by
            IL-6/Arid5a signaling, exacerbates breast cancer invasion and
            metastasis by stabilizing Trib3 and activating the Mek/Erk pathway.
REFERENCE   5  (residues 1 to 431)
  AUTHORS   Chalise JP, Hashimoto S, Parajuli G, Kang S, Singh SK, Gemechu Y,
            Metwally H, Nyati KK, Dubey PK, Zaman MM, Nagahama Y, Hamza H,
            Masuda K and Kishimoto T.
  TITLE     Feedback regulation of Arid5a and Ppar-gamma2 maintains adipose
            tissue homeostasis
  JOURNAL   Proc Natl Acad Sci U S A 116 (30), 15128-15133 (2019)
   PUBMED   31289228
  REMARK    GeneRIF: Feedback regulation of Arid5a and Ppar-gamma2 maintains
            adipose tissue homeostasis.
REFERENCE   6  (residues 1 to 431)
  AUTHORS   Zaman MM, Masuda K, Nyati KK, Dubey PK, Ripley B, Wang K, Chalise
            JP, Higa M, Hanieh H and Kishimoto T.
  TITLE     Arid5a exacerbates IFN-gamma-mediated septic shock by stabilizing
            T-bet mRNA
  JOURNAL   Proc Natl Acad Sci U S A 113 (41), 11543-11548 (2016)
   PUBMED   27671645
  REMARK    GeneRIF: Arid5a deficiency resulted in decreased levels of
            IFN-gamma under Th1 cell conditions, in which T-box expressed in T
            cells (T-bet) mRNA expression was inhibited.
REFERENCE   7  (residues 1 to 431)
  AUTHORS   Masuda K, Ripley B, Nyati KK, Dubey PK, Zaman MM, Hanieh H, Higa M,
            Yamashita K, Standley DM, Mashima T, Katahira M, Okamoto T,
            Matsuura Y, Takeuchi O and Kishimoto T.
  TITLE     Arid5a regulates naive CD4+ T cell fate through selective
            stabilization of Stat3 mRNA
  JOURNAL   J Exp Med 213 (4), 605-619 (2016)
   PUBMED   27022145
  REMARK    GeneRIF: T cell-intrinsic role of Arid5a on fate decisions of naive
            CD4(+)T cells through selective stabilization of Stat3 mRNA.
REFERENCE   8  (residues 1 to 431)
  AUTHORS   Masuda K, Ripley B, Nishimura R, Mino T, Takeuchi O, Shioi G,
            Kiyonari H and Kishimoto T.
  TITLE     Arid5a controls IL-6 mRNA stability, which contributes to elevation
            of IL-6 level in vivo
  JOURNAL   Proc Natl Acad Sci U S A 110 (23), 9409-9414 (2013)
   PUBMED   23676272
  REMARK    GeneRIF: Arid5a controls IL-6 mRNA stability, which contributes to
            elevation of IL-6 level in vivo.
REFERENCE   9  (residues 1 to 431)
  AUTHORS   Amano K, Hata K, Muramatsu S, Wakabayashi M, Takigawa Y, Ono K,
            Nakanishi M, Takashima R, Kogo M, Matsuda A, Nishimura R and Yoneda
            T.
  TITLE     Arid5a cooperates with Sox9 to stimulate chondrocyte-specific
            transcription
  JOURNAL   Mol Biol Cell 22 (8), 1300-1311 (2011)
   PUBMED   21346191
  REMARK    GeneRIF: AT-rich interactive domain-containing protein 5a (Arid5a)
            cooperates with Sox9 to stimulate chondrocyte-specific
            transcription.
REFERENCE   10 (residues 1 to 431)
  AUTHORS   Wilsker D, Probst L, Wain HM, Maltais L, Tucker PW and Moran E.
  TITLE     Nomenclature of the ARID family of DNA-binding proteins
  JOURNAL   Genomics 86 (2), 242-251 (2005)
   PUBMED   15922553
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY196834.1, CX209955.1, AK149839.1 and AK029237.1.
            
            On Mar 19, 2014 this sequence version replaced XP_006495915.1.
            
            Transcript Variant: This variant (6) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at a
            downstream start codon, compared to variant 1. The encoded protein
            (isoform 6) has a shorter N-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.2348202.1, CX209955.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..431
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 15.2 cM"
     Protein         1..431
                     /product="AT-rich interactive domain-containing protein 5A
                     isoform 6"
                     /note="AT rich interactive domain 5A (Mrf1 like);
                     modulator recognition factor I; AT-rich interactive
                     domain-containing protein 5A; ARID domain-containing
                     protein 5A; AT rich interactive domain 5A (MRF1-like)"
                     /calculated_mol_wt=45715
     CDS             1..431
                     /gene="Arid5a"
                     /gene_synonym="D430024K22Rik; Mrf1"
                     /coded_by="NM_001290727.1:454..1749"
                     /note="isoform 6 is encoded by transcript variant 6"
                     /db_xref="CCDS:CCDS69878.1"
                     /db_xref="GeneID:214855"
                     /db_xref="MGI:MGI:2443039"
ORIGIN      
        1 makelrgddg tteklkkakd seerrveqtt pgktksdatg qtqlpcqgss rdsteqlgpv
       61 sgpsppltga sscpeaykrl lssfyckgah gimsplakkk llaqvskaea lqcqeegcrh
      121 garspnkdiq dspqnlrgpa ensehqltpr eglqapggst rmeaqvgpcp tapmfsgcfh
      181 ayptevlkpv sqhprdffsg lkdrvllgpp gkeegpttke shlvwggdan hpsafhkgst
      241 rkrsfypkpk acwvspmakv pterpgapsp hpsspglgsk rgleeegfah ggkklravsp
      301 flkevdsket ggkpaapgla vscllgptpg ptppeayrgt mlrcplnftg sadplkgqas
      361 lpfsplvipa fpahllattg sspmaaslmh fpptpydavl rnrlgpassa whmppvttya
      421 aphffhlntk l
//
LOCUS       NP_001349214             533 aa            linear   ROD 09-OCT-2023
DEFINITION  CUGBP Elav-like family member 4 isoform 11 [Mus musculus].
ACCESSION   NP_001349214
VERSION     NP_001349214.1
DBSOURCE    REFSEQ: accession NM_001362285.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 533)
  AUTHORS   Salamon I, Park Y, Miskic T, Kopic J, Matteson P, Page NF, Roque A,
            McAuliffe GW, Favate J, Garcia-Forn M, Shah P, Judas M, Millonig
            JH, Kostovic I, De Rubeis S, Hart RP, Krsnik Z and Rasin MR.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    GeneRIF: Celf4 controls mRNA translation underlying synaptic
            development in the prenatal mammalian neocortex.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 533)
  AUTHORS   Shen Y, Zhang C, Xiao K, Liu D and Xie G.
  TITLE     CELF4 regulates spine formation and depression-like behaviors of
            mice
  JOURNAL   Biochem Biophys Res Commun 605, 39-44 (2022)
   PUBMED   35306363
  REMARK    GeneRIF: CELF4 regulates spine formation and depression-like
            behaviors of mice.
REFERENCE   3  (residues 1 to 533)
  AUTHORS   Moreau MX, Saillour Y, Cwetsch AW, Pierani A and Causeret F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   4  (residues 1 to 533)
  AUTHORS   Li C, Li X, Bi Z, Sugino K, Wang G, Zhu T and Liu Z.
  TITLE     Comprehensive transcriptome analysis of cochlear spiral ganglion
            neurons at multiple ages
  JOURNAL   Elife 9, e50491 (2020)
   PUBMED   31913118
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 533)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 533)
  AUTHORS   Ladd AN, Taffet G, Hartley C, Kearney DL and Cooper TA.
  TITLE     Cardiac tissue-specific repression of CELF activity disrupts
            alternative splicing and causes cardiomyopathy
  JOURNAL   Mol Cell Biol 25 (14), 6267-6278 (2005)
   PUBMED   15988035
  REMARK    GeneRIF: CELF protein activity is required for normal alternative
            splicing in the heart in vivo and normal CELF-mediated alternative
            splicing regulation is in turn required for normal cardiac
            function.
REFERENCE   7  (residues 1 to 533)
  AUTHORS   Meins M, Schlickum S, Wilhelm C, Missbach J, Yadav S, Glaser B,
            Grzmil M, Burfeind P and Laccone F.
  TITLE     Identification and characterization of murine Brunol4, a new member
            of the elav/bruno family
  JOURNAL   Cytogenet Genome Res 97 (3-4), 254-260 (2002)
   PUBMED   12438720
  REMARK    GeneRIF: cloning and characterization
REFERENCE   8  (residues 1 to 533)
  AUTHORS   Ladd AN, Charlet N and Cooper TA.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   9  (residues 1 to 533)
  AUTHORS   Good PJ, Chen Q, Warner SJ and Herring DC.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
REFERENCE   10 (residues 1 to 533)
  AUTHORS   Yulug IG, Egan SE, See CG and Fisher EM.
  TITLE     Mapping GRB2, a signal transduction gene in the human and the mouse
  JOURNAL   Genomics 22 (2), 313-318 (1994)
   PUBMED   7806216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121094.8 and AC144938.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.198182.1,
                                           SRR1660817.302190.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..533
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 13.92 cM"
     Protein         1..533
                     /product="CUGBP Elav-like family member 4 isoform 11"
                     /note="CUG-BP- and ETR-3-like factor 4; bruno-like protein
                     4; RNA-binding protein BRUNOL-4; bruno-like 4, RNA binding
                     protein"
                     /calculated_mol_wt=56716
     Region          18..39
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          49..135
                     /region_name="RRM1_CELF3_4_5_6"
                     /note="RNA recognition motif 1 (RRM1) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12632"
                     /db_xref="CDD:410041"
     Site            order(55,57,59..60,63,82,84,86,95..97,99,129,131)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410041"
     Region          121..149
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          150..230
                     /region_name="RRM2_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12635"
                     /db_xref="CDD:410043"
     Site            order(152,154,156..157,160,179,181,183,191..193,195,225,
                     227)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410043"
     Region          238..257
                     /region_name="Necessary for TNNT2 exon 5 inclusion.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          414..>442
                     /region_name="RRM_SF"
                     /note="RNA recognition motif (RRM) superfamily; cl17169"
                     /db_xref="CDD:450164"
     CDS             1..533
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /coded_by="NM_001362285.1:531..2132"
                     /note="isoform 11 is encoded by transcript variant 17"
                     /db_xref="GeneID:108013"
                     /db_xref="MGI:MGI:1932407"
ORIGIN      
        1 myikmatlan gqadnaslst nglgsspgsa ghmnglshsp gnpstipmkd hdaiklfigq
       61 iprnldekdl kplfeefgki yeltvlkdrf tgmhkgcafl tyceresalk aqsalheqkt
      121 lpgmnrpiqv kpadsesrgg ssclrqppsh rklfvgmlnk qqseddvrrl feafgnieec
      181 tilrgpdgns kgcafvkyss haeaqaaina lhgsqtmpga ssslvvkfad tdkertmrrm
      241 qqmagqmgmf npmaipfgay gayaqamqqq aalmasvaqg gylnpmaafa aaqmqqmaal
      301 nmnglaaapm tptsggstpp gitapavpsi pspigvngft glppqangqp aaeavfangi
      361 hpypaqspta adplqqayag vqqyagpayp aaygqisqaf pqpppmipqq qregpegcnl
      421 liyhlpqefg daelmqmflp fgrhpvpsrc qapscqggqc aisssarrlr elrqpgqrtd
      481 rhpgherlpd rheeaqgaae aaqrrqspvl saggsvprgr pglaqgrmln glh
//
LOCUS       NP_032357                463 aa            linear   ROD 09-OCT-2023
DEFINITION  interferon-induced protein with tetratricopeptide repeats 1 [Mus
            musculus].
ACCESSION   NP_032357
VERSION     NP_032357.2
DBSOURCE    REFSEQ: accession NM_008331.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 463)
  AUTHORS   Lu YJ, Deng YT, Ko HH, Peng HH, Lee HC, Kuo MY and Cheng SJ.
  TITLE     Lysyl oxidase-like 2 promotes stemness and enhances antitumor
            effects of gefitinib in head and neck cancer via IFIT1 and IFIT3
  JOURNAL   Cancer Sci 114 (10), 3957-3971 (2023)
   PUBMED   37496288
  REMARK    GeneRIF: Lysyl oxidase-like 2 promotes stemness and enhances
            antitumor effects of gefitinib in head and neck cancer via IFIT1
            and IFIT3.
REFERENCE   2  (residues 1 to 463)
  AUTHORS   Zengeler KE, Shapiro DA, Bruch KR, Lammert CR, Ennerfelt H and
            Lukens JR.
  TITLE     SSRI treatment modifies the effects of maternal inflammation on in
            utero physiology and offspring neurobiology
  JOURNAL   Brain Behav Immun 108, 80-97 (2023)
   PUBMED   36343752
REFERENCE   3  (residues 1 to 463)
  AUTHORS   Rupani DN, Thege FI, Chandra V, Rajaei H, Cowan RW, Wormann SM, Le
            Roux O, Malaney P, Manning SL, Hashem J, Bailey-Lundberg J, Rhim AD
            and McAllister F.
  TITLE     Adar1 deletion causes degeneration of the exocrine pancreas via
            Mavs-dependent interferon signaling
  JOURNAL   Development 150 (2) (2023)
   PUBMED   36458554
REFERENCE   4  (residues 1 to 463)
  AUTHORS   Jiang W, Zhang Y, Sheng Y, Liu M, Du C, Pan X, Huang C, Li J and
            Wang Y.
  TITLE     Overexpression of IFIT1 protects against LPS-induced acute lung
            injury via regulating CCL5-p65NF-kappaB signaling
  JOURNAL   Int Immunopharmacol 114, 109485 (2023)
   PUBMED   36446235
  REMARK    GeneRIF: Overexpression of IFIT1 protects against LPS-induced acute
            lung injury via regulating CCL5-p65NF-kappaB signaling.
REFERENCE   5  (residues 1 to 463)
  AUTHORS   de Reuver R, Verdonck S, Dierick E, Nemegeer J, Hessmann E, Ahmad
            S, Jans M, Blancke G, Van Nieuwerburgh F, Botzki A, Vereecke L, van
            Loo G, Declercq W, Hur S, Vandenabeele P and Maelfait J.
  TITLE     ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1
            activation
  JOURNAL   Nature 607 (7920), 784-789 (2022)
   PUBMED   35859175
REFERENCE   6  (residues 1 to 463)
  AUTHORS   Williams TM, Williams ME, Kuick R, Misek D, McDonagh K, Hanash S
            and Innis JW.
  TITLE     Candidate downstream regulated genes of HOX group 13 transcription
            factors with and without monomeric DNA binding capability
  JOURNAL   Dev Biol 279 (2), 462-480 (2005)
   PUBMED   15733672
REFERENCE   7  (residues 1 to 463)
  AUTHORS   Hui DJ, Terenzi F, Merrick WC and Sen GC.
  TITLE     Mouse p56 blocks a distinct function of eukaryotic initiation
            factor 3 in translation initiation
  JOURNAL   J Biol Chem 280 (5), 3433-3440 (2005)
   PUBMED   15561726
  REMARK    GeneRIF: block different functions of eIF3 by binding to its
            different subunits.
REFERENCE   8  (residues 1 to 463)
  AUTHORS   Smith JB and Herschman HR.
  TITLE     The glucocorticoid attenuated response genes GARG-16, GARG-39, and
            GARG-49/IRG2 encode inducible proteins containing multiple
            tetratricopeptide repeat domains
  JOURNAL   Arch Biochem Biophys 330 (2), 290-300 (1996)
   PUBMED   8660659
REFERENCE   9  (residues 1 to 463)
  AUTHORS   Smith JB and Herschman HR.
  TITLE     Glucocorticoid-attenuated response genes encode intercellular
            mediators, including a new C-X-C chemokine
  JOURNAL   J Biol Chem 270 (28), 16756-16765 (1995)
   PUBMED   7622488
REFERENCE   10 (residues 1 to 463)
  AUTHORS   Bluyssen HA, Vlietstra RJ, Faber PW, Smit EM, Hagemeijer A and
            Trapman J.
  TITLE     Structure, chromosome localization, and regulation of expression of
            the interferon-regulated mouse Ifi54/Ifi56 gene family
  JOURNAL   Genomics 24 (1), 137-148 (1994)
   PUBMED   7896268
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK150424.1.
            
            On Jul 23, 2006 this sequence version replaced NP_032357.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK150424.1, AK151298.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..463
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 29.78 cM"
     Protein         1..463
                     /product="interferon-induced protein with
                     tetratricopeptide repeats 1"
                     /note="interferon-induced 56 kDa protein;
                     glucocorticoid-attenuated response gene 16 protein"
                     /calculated_mol_wt=53607
     Region          <25..235
                     /region_name="PEP_TPR_lipo"
                     /note="putative PEP-CTERM system TPR-repeat lipoprotein;
                     TIGR02917"
                     /db_xref="CDD:274350"
     Site            34
                     /site_type="other"
                     /note="Interaction with PPP-RNA. /evidence=ECO:0000250;
                     propagated from UniProtKB/Swiss-Prot (Q64282.2)"
     Site            42
                     /site_type="other"
                     /note="Interaction with PPP-RNA. /evidence=ECO:0000250;
                     propagated from UniProtKB/Swiss-Prot (Q64282.2)"
     Region          52..85
                     /region_name="TPR 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64282.2)"
     Region          55..86
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          91..121
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          92..126
                     /region_name="TPR 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64282.2)"
     Region          136..171
                     /region_name="TPR 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64282.2)"
     Region          136..166
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(137,140..141,144..145,147,173,176..177,180..181,
                     183..184,209,212..213,216..217,220)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Site            148
                     /site_type="other"
                     /note="Interaction with PPP-RNA. /evidence=ECO:0000250;
                     propagated from UniProtKB/Swiss-Prot (Q64282.2)"
     Region          <152..>462
                     /region_name="PEP_TPR_lipo"
                     /note="putative PEP-CTERM system TPR-repeat lipoprotein;
                     TIGR02917"
                     /db_xref="CDD:274350"
     Region          171..203
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          174..207
                     /region_name="TPR 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64282.2)"
     Site            184
                     /site_type="other"
                     /note="Interaction with PPP-RNA. /evidence=ECO:0000250;
                     propagated from UniProtKB/Swiss-Prot (Q64282.2)"
     Region          208..236
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          209..241
                     /region_name="TPR 5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64282.2)"
     Region          242..275
                     /region_name="TPR 6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64282.2)"
     Region          242..270
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(243,246..247,250..251,253,277,280..281,284..285,
                     287..288,330,333..334,337..338,341)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Site            243
                     /site_type="other"
                     /note="Interaction with PPP-RNA. /evidence=ECO:0000250;
                     propagated from UniProtKB/Swiss-Prot (Q64282.2)"
     Region          247..253
                     /region_name="Interaction with the 5'-triphosphate group
                     of PPP-RNA. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64282.2)"
     Region          275..324
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            281
                     /site_type="other"
                     /note="Interaction with the 5'-triphosphate group of
                     PPP-RNA. /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (Q64282.2)"
     Region          294..328
                     /region_name="TPR 7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64282.2)"
     Region          329..362
                     /region_name="TPR 8"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64282.2)"
     Region          329..356
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          367..401
                     /region_name="TPR 9"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64282.2)"
     Region          426..459
                     /region_name="TPR 10"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64282.2)"
     CDS             1..463
                     /gene="Ifit1"
                     /gene_synonym="GARG-16; IFI-56K; Ifi56; ISG56; P56"
                     /coded_by="NM_008331.3:95..1486"
                     /db_xref="CCDS:CCDS29766.1"
                     /db_xref="GeneID:15957"
                     /db_xref="MGI:MGI:99450"
ORIGIN      
        1 mgenadgdqv menllqlrch ftwkllfenn dipdlevris eqvqfldikn plgmhnllay
       61 vrhlkgqqde alqslkeaea liqseqlskr slatwgncaw lhyhrgslae aqiyldkvek
      121 vckefsspfr yrlecaemdc eegwallkcg ggnykqamac fakalkvepe npeyntgyav
      181 vayrqdlddn fisleplrka vrlnpedpyl kvllalklqd lgehveaeah ieealsstsc
      241 qsyviryaak yfrrkhrvdk alhllnralq aspssgylhy qkglcykqqi sqlrtsrnrq
      301 prrqdnvqel aqqaihefqe tlklrptfem ayvcmaevqa eihqyeeaer nfqkalnnkt
      361 lvahieqdih lrygrflqfh kqsedkaitl ylkglkveek sfawrkllta lekvaerrvc
      421 qnvhlvests llglvyklkg qeknalfyye kalrltgemn paf
//
LOCUS       NP_001344556             749 aa            linear   ROD 09-OCT-2023
DEFINITION  signal transducer and activator of transcription 1 isoform 2 [Mus
            musculus].
ACCESSION   NP_001344556 XP_006495874
VERSION     NP_001344556.1
DBSOURCE    REFSEQ: accession NM_001357627.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 749)
  AUTHORS   Kong P, Yang M, Wang Y, Yu KN, Wu L and Han W.
  TITLE     Ferroptosis triggered by STAT1- IRF1-ACSL4 pathway was involved in
            radiation-induced intestinal injury
  JOURNAL   Redox Biol 66, 102857 (2023)
   PUBMED   37611494
  REMARK    GeneRIF: Ferroptosis triggered by STAT1- IRF1-ACSL4 pathway was
            involved in radiation-induced intestinal injury.
REFERENCE   2  (residues 1 to 749)
  AUTHORS   Clark DN, O'Neil SM, Xu L, Steppe JT, Savage JT, Raghunathan K and
            Filiano AJ.
  TITLE     Prolonged STAT1 activation in neurons drives a pathological
            transcriptional response
  JOURNAL   J Neuroimmunol 382, 578168 (2023)
   PUBMED   37556887
  REMARK    GeneRIF: Prolonged STAT1 activation in neurons drives a
            pathological transcriptional response.
REFERENCE   3  (residues 1 to 749)
  AUTHORS   Imitola J, Hollingsworth EW, Watanabe F, Olah M, Elyaman W,
            Starossom S, Kivisakk P and Khoury SJ.
  TITLE     Stat1 is an inducible transcriptional repressor of neural stem
            cells self-renewal program during neuroinflammation
  JOURNAL   Front Cell Neurosci 17, 1156802 (2023)
   PUBMED   37663126
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 749)
  AUTHORS   Han W, Pu H, Li S, Liu Y, Zhao Y, Xu M, Chen C, Wu Y, Yang T, Ye Q,
            Wang H, Stetler RA, Chen J and Shi Y.
  TITLE     Targeted ablation of signal transducer and activator of
            transduction 1 alleviates inflammation by microglia/macrophages and
            promotes long-term recovery after ischemic stroke
  JOURNAL   J Neuroinflammation 20 (1), 178 (2023)
   PUBMED   37516843
  REMARK    GeneRIF: Targeted ablation of signal transducer and activator of
            transduction 1 alleviates inflammation by microglia/macrophages and
            promotes long-term recovery after ischemic stroke.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 749)
  AUTHORS   Largent AD, Lambert K, Chiang K, Shumlak N, Liggitt D, Oukka M,
            Torgerson TR, Buckner JH, Allenspach EJ, Rawlings DJ and Jackson
            SW.
  TITLE     Dysregulated IFN-gamma signals promote autoimmunity in STAT1
            gain-of-function syndrome
  JOURNAL   Sci Transl Med 15 (703), eade7028 (2023)
   PUBMED   37406138
REFERENCE   6  (residues 1 to 749)
  AUTHORS   Novak U, Harpur AG, Paradiso L, Kanagasundaram V, Jaworowski A,
            Wilks AF and Hamilton JA.
  TITLE     Colony-stimulating factor 1-induced STAT1 and STAT3 activation is
            accompanied by phosphorylation of Tyk2 in macrophages and Tyk2 and
            JAK1 in fibroblasts
  JOURNAL   Blood 86 (8), 2948-2956 (1995)
   PUBMED   7579387
REFERENCE   7  (residues 1 to 749)
  AUTHORS   Finidori J and Kelly PA.
  TITLE     Cytokine receptor signalling through two novel families of
            transducer molecules: Janus kinases, and signal transducers and
            activators of transcription
  JOURNAL   J Endocrinol 147 (1), 11-23 (1995)
   PUBMED   7490523
  REMARK    Review article
REFERENCE   8  (residues 1 to 749)
  AUTHORS   Harroch S, Gothelf Y, Revel M and Chebath J.
  TITLE     5' upstream sequences of MyD88, an IL-6 primary response gene in M1
            cells: detection of functional IRF-1 and Stat factors binding sites
  JOURNAL   Nucleic Acids Res 23 (17), 3539-3546 (1995)
   PUBMED   7567467
REFERENCE   9  (residues 1 to 749)
  AUTHORS   Matsuda T and Hirano T.
  TITLE     Association of p72 tyrosine kinase with Stat factors and its
            activation by interleukin-3, interleukin-6, and granulocyte
            colony-stimulating factor
  JOURNAL   Blood 83 (12), 3457-3461 (1994)
   PUBMED   7515712
REFERENCE   10 (residues 1 to 749)
  AUTHORS   Zhong Z, Wen Z and Darnell JE Jr.
  TITLE     Stat3 and Stat4: members of the family of signal transducers and
            activators of transcription
  JOURNAL   Proc Natl Acad Sci U S A 91 (11), 4806-4810 (1994)
   PUBMED   7545930
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123752.8.
            
            On Nov 4, 2017 this sequence version replaced XP_006495874.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.16280.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..749
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 26.81 cM"
     Protein         1..749
                     /product="signal transducer and activator of transcription
                     1 isoform 2"
                     /calculated_mol_wt=87184
     Region          2..121
                     /region_name="STAT_int"
                     /note="STAT protein, protein interaction domain;
                     smart00964"
                     /db_xref="CDD:214942"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylserine.
                     /evidence=ECO:0000250|UniProtKB:P42224; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     Site            114
                     /site_type="methylation"
                     /note="N6-methyllysine.
                     /evidence=ECO:0000250|UniProtKB:P42224; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     Region          138..313
                     /region_name="STAT1_CCD"
                     /note="Coiled-coil domain of Signal Transducer and
                     Activator of Transcription 1 (STAT1); cd16851"
                     /db_xref="CDD:341076"
     Site            order(164..165,168..169,172,175..176,179,232,236,239..241,
                     243..244,256..257,259..260,263..264,267,271,274,306,
                     309..311)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:341076"
     Site            175
                     /site_type="methylation"
                     /note="N6-methyllysine.
                     /evidence=ECO:0000250|UniProtKB:P42224; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     Site            order(239..241,243..244,256..257,260,263..264,267,271,274,
                     302,306,309..310)
                     /site_type="other"
                     /note="CCD-DBD interface [polypeptide binding]"
                     /db_xref="CDD:341076"
     Site            296
                     /site_type="methylation"
                     /note="N6-methyllysine.
                     /evidence=ECO:0000250|UniProtKB:P42224; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     Region          317..477
                     /region_name="STAT1_DBD"
                     /note="DNA-binding domain of Signal Transducer and
                     Activator of Transcription 1 (STAT1); cd16845"
                     /db_xref="CDD:341083"
     Site            order(336,340,378,411,413,426..427,459..460,463)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:341083"
     Site            366
                     /site_type="methylation"
                     /note="N6-methyllysine.
                     /evidence=ECO:0000250|UniProtKB:P42224; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     Site            525
                     /site_type="methylation"
                     /note="N6-methyllysine.
                     /evidence=ECO:0000250|UniProtKB:P42224; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     Region          557..707
                     /region_name="SH2_STAT1"
                     /note="Src homology 2 (SH2) domain found in signal
                     transducer and activator of transcription (STAT) 1
                     proteins; cd10372"
                     /db_xref="CDD:198235"
     Site            order(584,602,630,632)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198235"
     Site            order(631,647)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198235"
     Site            637
                     /site_type="methylation"
                     /note="N6-methyllysine.
                     /evidence=ECO:0000250|UniProtKB:P42224; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     Site            order(641..642,706)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:198235"
     Site            665
                     /site_type="methylation"
                     /note="N6-methyllysine.
                     /evidence=ECO:0000250|UniProtKB:P42224; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     Site            701
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by JAK1, JAK2 or TYK2.
                     /evidence=ECO:0000269|PubMed:19088846,
                     ECO:0000269|PubMed:22065572; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     Site            708
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by IKKE.
                     /evidence=ECO:0000269|PubMed:17332413,
                     ECO:0000269|PubMed:22065572; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     Region          715..739
                     /region_name="STAT1_TAZ2bind"
                     /note="STAT1 TAZ2 binding domain; pfam12162"
                     /db_xref="CDD:432372"
     Site            724
                     /site_type="other"
                     /note="Required for recruitment of EP300/p300.
                     /evidence=ECO:0000250|UniProtKB:P42224; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     Site            727
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CaMK2 and MAPK14.
                     /evidence=ECO:0000269|PubMed:11972023,
                     ECO:0000269|PubMed:22065572; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     Site            744
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by IKKE.
                     /evidence=ECO:0000305|PubMed:17332413; propagated from
                     UniProtKB/Swiss-Prot (P42225.1)"
     CDS             1..749
                     /gene="Stat1"
                     /gene_synonym="2010005J02Rik"
                     /coded_by="NM_001357627.1:314..2563"
                     /note="isoform 2 is encoded by transcript variant 4"
                     /db_xref="CCDS:CCDS56628.1"
                     /db_xref="GeneID:20846"
                     /db_xref="MGI:MGI:103063"
ORIGIN      
        1 msqwfelqql dskfleqvhq lyddsfpmei rqylaqwlek qdwehaaydv sfatirfhdl
       61 lsqlddqysr fslennfllq hnirkskrnl qdnfqedpvq msmiiynclk eerkilenaq
      121 rfnqaqegni qntvmldkqk eldskvrnvk dqvmcieqei ktleelqdey dfkcktsqnr
      181 egeangvaks dqkqeqlllh kmflmldnkr keiihkirel lnsieltqnt lindelvewk
      241 rrqqsacigg ppnacldqlq swftivaetl qqirqqlkkl eeleqkftye pdpitknkqv
      301 lsdrtfllfq qliqssfvve rqpcmpthpq rplvlktgvq ftvklrllvk lqelnynlkv
      361 kvsfdkdvne kntvkgfrkf nilgthtkvm nmeestngsl aaefrhlqlk eqknagnrtn
      421 egplivteel hslsfetqlc qpglvidlet tslpvvvisn vsqlpsgwas ilwynmlvte
      481 prnlsfflnp pcawwsqlse vlswqfssvt krglnadqls mlgekllgpn agpdglipwt
      541 rfckenindk nfsfwpwidt ilelikkhll clwndgcimg fiskereral lkdqqpgtfl
      601 lrfsessreg aitftwvers qnggepdfha vepytkkels avtfpdiirn ykvmaaenip
      661 enplkylypn idkdhafgky ysrpkeapep melddpkrtg yiktelisvs evhpsrlqtt
      721 dnllpmspee fdemsrivgp efdsmmstv
//
LOCUS       NP_001349215             526 aa            linear   ROD 09-OCT-2023
DEFINITION  CUGBP Elav-like family member 4 isoform 12 [Mus musculus].
ACCESSION   NP_001349215
VERSION     NP_001349215.1
DBSOURCE    REFSEQ: accession NM_001362286.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 526)
  AUTHORS   Salamon I, Park Y, Miskic T, Kopic J, Matteson P, Page NF, Roque A,
            McAuliffe GW, Favate J, Garcia-Forn M, Shah P, Judas M, Millonig
            JH, Kostovic I, De Rubeis S, Hart RP, Krsnik Z and Rasin MR.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    GeneRIF: Celf4 controls mRNA translation underlying synaptic
            development in the prenatal mammalian neocortex.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 526)
  AUTHORS   Shen Y, Zhang C, Xiao K, Liu D and Xie G.
  TITLE     CELF4 regulates spine formation and depression-like behaviors of
            mice
  JOURNAL   Biochem Biophys Res Commun 605, 39-44 (2022)
   PUBMED   35306363
  REMARK    GeneRIF: CELF4 regulates spine formation and depression-like
            behaviors of mice.
REFERENCE   3  (residues 1 to 526)
  AUTHORS   Moreau MX, Saillour Y, Cwetsch AW, Pierani A and Causeret F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   4  (residues 1 to 526)
  AUTHORS   Li C, Li X, Bi Z, Sugino K, Wang G, Zhu T and Liu Z.
  TITLE     Comprehensive transcriptome analysis of cochlear spiral ganglion
            neurons at multiple ages
  JOURNAL   Elife 9, e50491 (2020)
   PUBMED   31913118
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 526)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 526)
  AUTHORS   Ladd AN, Taffet G, Hartley C, Kearney DL and Cooper TA.
  TITLE     Cardiac tissue-specific repression of CELF activity disrupts
            alternative splicing and causes cardiomyopathy
  JOURNAL   Mol Cell Biol 25 (14), 6267-6278 (2005)
   PUBMED   15988035
  REMARK    GeneRIF: CELF protein activity is required for normal alternative
            splicing in the heart in vivo and normal CELF-mediated alternative
            splicing regulation is in turn required for normal cardiac
            function.
REFERENCE   7  (residues 1 to 526)
  AUTHORS   Meins M, Schlickum S, Wilhelm C, Missbach J, Yadav S, Glaser B,
            Grzmil M, Burfeind P and Laccone F.
  TITLE     Identification and characterization of murine Brunol4, a new member
            of the elav/bruno family
  JOURNAL   Cytogenet Genome Res 97 (3-4), 254-260 (2002)
   PUBMED   12438720
  REMARK    GeneRIF: cloning and characterization
REFERENCE   8  (residues 1 to 526)
  AUTHORS   Ladd AN, Charlet N and Cooper TA.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   9  (residues 1 to 526)
  AUTHORS   Good PJ, Chen Q, Warner SJ and Herring DC.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
REFERENCE   10 (residues 1 to 526)
  AUTHORS   Yulug IG, Egan SE, See CG and Fisher EM.
  TITLE     Mapping GRB2, a signal transduction gene in the human and the mouse
  JOURNAL   Genomics 22 (2), 313-318 (1994)
   PUBMED   7806216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121094.8 and AC144938.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.30545.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..526
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 13.92 cM"
     Protein         1..526
                     /product="CUGBP Elav-like family member 4 isoform 12"
                     /note="CUG-BP- and ETR-3-like factor 4; bruno-like protein
                     4; RNA-binding protein BRUNOL-4; bruno-like 4, RNA binding
                     protein"
                     /calculated_mol_wt=55979
     Region          49..135
                     /region_name="RRM1_CELF3_4_5_6"
                     /note="RNA recognition motif 1 (RRM1) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12632"
                     /db_xref="CDD:410041"
     Site            order(55,57,59..60,63,82,84,86,95..97,99,129,131)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410041"
     Region          142..222
                     /region_name="RRM2_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12635"
                     /db_xref="CDD:410043"
     Site            order(144,146,148..149,152,171,173,175,183..185,187,217,
                     219)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410043"
     Region          407..>435
                     /region_name="RRM_SF"
                     /note="RNA recognition motif (RRM) superfamily; cl17169"
                     /db_xref="CDD:450164"
     CDS             1..526
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /coded_by="NM_001362286.1:531..2111"
                     /note="isoform 12 is encoded by transcript variant 18"
                     /db_xref="GeneID:108013"
                     /db_xref="MGI:MGI:1932407"
ORIGIN      
        1 myikmatlan gqadnaslst nglgsspgsa ghmnglshsp gnpstipmkd hdaiklfigq
       61 iprnldekdl kplfeefgki yeltvlkdrf tgmhkgcafl tyceresalk aqsalheqkt
      121 lpgmnrpiqv kpadsesrgg kdrklfvgml nkqqseddvr rlfeafgnie ectilrgpdg
      181 nskgcafvky sshaeaqaai nalhgsqtmp gassslvvkf adtdkertmr rmqqmagqmg
      241 mfnpmaipfg aygayaqalm qqqaalmasv aqggylnpma afaaaqmqqm aalnmnglaa
      301 apmtptsggs tppgitapav psipspigvn gftglppqan gqpaaeavfa ngihpypaqs
      361 ptaadplqqa yagvqqyagp aypaaygqis qafpqpppmi pqqqregpeg cnlliyhlpq
      421 efgdaelmqm flpfgrhpvp srcqapscqg gqcaisssar rlrelrqpgq rtdrhpgher
      481 lpdrheeaqg aaeaaqrrqs pvlsaggsvp rgrpglaqgr mlnglh
//
LOCUS       NP_001305060             422 aa            linear   ROD 09-OCT-2023
DEFINITION  mitogen-activated protein kinase 10 isoform 6 [Mus musculus].
ACCESSION   NP_001305060 XP_006535013
VERSION     NP_001305060.1
DBSOURCE    REFSEQ: accession NM_001318131.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 422)
  AUTHORS   Priego M, Noriega L, Kalinin S, Hoffman LM, Feinstein DL and
            Morfini G.
  TITLE     Genetic deletion of c-Jun amino-terminal kinase 3 (JNK3) modestly
            increases disease severity in a mouse model of multiple sclerosis
  JOURNAL   J Neuroimmunol 382, 578152 (2023)
   PUBMED   37454525
  REMARK    GeneRIF: Genetic deletion of c-Jun amino-terminal kinase 3 (JNK3)
            modestly increases disease severity in a mouse model of multiple
            sclerosis.
REFERENCE   2  (residues 1 to 422)
  AUTHORS   Liu F, Deng Y, Zhao Y, Li Z, Gao J, Zhang Y, Yang X, Liu Y and Xia
            Y.
  TITLE     Time series RNA-seq analysis identifies MAPK10 as a critical gene
            in diabetes mellitus-induced atrial fibrillation in mice
  JOURNAL   J Mol Cell Cardiol 168, 70-82 (2022)
   PUBMED   35489387
  REMARK    GeneRIF: Time series RNA-seq analysis identifies MAPK10 as a
            critical gene in diabetes mellitus-induced atrial fibrillation in
            mice.
REFERENCE   3  (residues 1 to 422)
  AUTHORS   Cunningham JG, Scripter JD, Nti SA and Tucker ES.
  TITLE     Early construction of the thalamocortical axon pathway requires
            c-Jun N-terminal kinase signaling within the ventral forebrain
  JOURNAL   Dev Dyn 251 (3), 459-480 (2022)
   PUBMED   34494344
REFERENCE   4  (residues 1 to 422)
  AUTHORS   Goodwani S, Fernandez C, Acton PJ, Buggia-Prevot V, McReynolds ML,
            Ma J, Hu CH, Hamby ME, Jiang Y, Le K, Soth MJ, Jones P and Ray WJ.
  TITLE     Dual Leucine Zipper Kinase Is Constitutively Active in the Adult
            Mouse Brain and Has Both Stress-Induced and Homeostatic Functions
  JOURNAL   Int J Mol Sci 21 (14), 4849 (2020)
   PUBMED   32659913
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 422)
  AUTHORS   Loughran G, Chou MY, Ivanov IP, Jungreis I, Kellis M, Kiran AM,
            Baranov PV and Atkins JF.
  TITLE     Evidence of efficient stop codon readthrough in four mammalian
            genes
  JOURNAL   Nucleic Acids Res 42 (14), 8928-8938 (2014)
   PUBMED   25013167
REFERENCE   6  (residues 1 to 422)
  AUTHORS   Beier H and Grimm M.
  TITLE     Misreading of termination codons in eukaryotes by natural nonsense
            suppressor tRNAs
  JOURNAL   Nucleic Acids Res 29 (23), 4767-4782 (2001)
   PUBMED   11726686
  REMARK    Review article
REFERENCE   7  (residues 1 to 422)
  AUTHORS   Yang DD, Kuan CY, Whitmarsh AJ, Rincon M, Zheng TS, Davis RJ, Rakic
            P and Flavell RA.
  TITLE     Absence of excitotoxicity-induced apoptosis in the hippocampus of
            mice lacking the Jnk3 gene
  JOURNAL   Nature 389 (6653), 865-870 (1997)
   PUBMED   9349820
REFERENCE   8  (residues 1 to 422)
  AUTHORS   Casanova E, Garate C, Ovalle S, Calvo P and Chinchetru MA.
  TITLE     Identification of four splice variants of the mouse
            stress-activated protein kinase JNK/SAPK alpha-isoform
  JOURNAL   Neuroreport 7 (7), 1320-1324 (1996)
   PUBMED   8817558
REFERENCE   9  (residues 1 to 422)
  AUTHORS   Martin JH, Mohit AA and Miller CA.
  TITLE     Developmental expression in the mouse nervous system of the p493F12
            SAP kinase
  JOURNAL   Brain Res Mol Brain Res 35 (1-2), 47-57 (1996)
   PUBMED   8717339
REFERENCE   10 (residues 1 to 422)
  AUTHORS   Suzuki J, Yoshida S, Chen ZL, Momota Y, Kato K, Hirata A and
            Shiosaka S.
  TITLE     Ontogeny of neuropsin mRNA expression in the mouse brain
  JOURNAL   Neurosci Res 23 (4), 345-351 (1995)
   PUBMED   8602273
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC160244.11, AC123664.15,
            AC137121.9 and AC125252.7.
            
            On Jun 6, 2022 this sequence version replaced XP_006535013.1.
            
            Summary: The protein encoded by this gene is a member of the MAP
            kinase family. MAP kinases act as integration points for multiple
            biochemical signals, and thus are involved in a wide variety of
            cellular processes, such as proliferation, differentiation,
            transcription regulation and development. This kinase is
            specifically expressed in a subset of neurons in the nervous system
            and is activated by threonine and tyrosine phosphorylation.
            Targeted deletion of this gene in mice suggests that it may have a
            role in stress-induced neuronal apoptosis. Alternatively spliced
            transcript variants encoding different isoforms have been found for
            this gene. A recent study provided evidence for translational
            readthrough in this gene, and expression of an additional
            C-terminally extended isoform via the use of an alternative
            in-frame translation termination codon. [provided by RefSeq, Dec
            2017].
            
            Transcript Variant: This variant (6) contains an alternate in-frame
            coding exon and uses an alternate acceptor splice site at the 3'
            terminal exon (which causes a frameshift) compared to variant 1.
            The resulting isoform (6, also known as JNK3 beta1) has a
            different, internal 24 aa protein segment and a shorter and
            distinct C-terminus compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.124455.1,
                                           SRR17784649.656111.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849376 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..422
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 49.61 cM"
     Protein         1..422
                     /product="mitogen-activated protein kinase 10 isoform 6"
                     /EC_number="2.7.11.24"
                     /note="JNK3 beta1 protein kinase; JNK3 beta2 protein
                     kinase; MAP kinase 10; MAP kinase p49 3F12; c-Jun
                     N-terminal kinase 3; stress-activated protein kinase JNK3;
                     SAPK/Erk/kinase 2"
                     /calculated_mol_wt=48126
     Region          63..398
                     /region_name="STKc_JNK"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     c-Jun N-terminal Kinase; cd07850"
                     /db_xref="CDD:270840"
     Site            order(70..76,78,91,93,110,124,146..152,154..155,189,191,
                     193..194,196,206..207,210,221,223..226,228,265)
                     /site_type="active"
                     /db_xref="CDD:270840"
     Site            order(70..76,78,91,93,124,146..152,196,206)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270840"
     Site            order(110,154,189,191,210,221,223..226,228,265)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270840"
     Site            order(150,156,165,168,197..201,361..362,364,367)
                     /site_type="other"
                     /note="KIM docking site [polypeptide binding]"
                     /db_xref="CDD:270840"
     Site            order(206..216,220..228)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270840"
     CDS             1..422
                     /gene="Mapk10"
                     /gene_synonym="C230008H04Rik; JNK3; JNK3B1; JNK3B2;
                     p493F12; p54bSAPK; SAPK(beta); Serk2"
                     /coded_by="NM_001318131.2:517..1785"
                     /note="isoform 6 is encoded by transcript variant 6"
                     /db_xref="GeneID:26414"
                     /db_xref="MGI:MGI:1346863"
ORIGIN      
        1 mslhflyycs eptldvkiaf cqgfdkhvdv ssiakhynms kskvdnqfys vevgdstftv
       61 lkryqnlkpi gsgaqgivca aydavldrnv aikklsrpfq nqthakrayr elvlmkcvnh
      121 kniisllnvf tpqktleefq dvylvmelmd anlcqviqme ldhermsyll yqmlcgikhl
      181 hsagiihrdl kpsnivvksd ctlkildfgl artagtsfmm tpyvvtryyr apevilgmgy
      241 kenvdlwsvg cimgemvkgt vlfpgtdhid qwnkvieqlg tpcpefmkkl qptvrnyven
      301 rpkyagltfp klfpdslfpa dsehnklkas qardllskml vidpakrisv ddalqhpyin
      361 vwydpaevea pppqiydkql derehtieew keliykevmn seektkngvv kgqpspsaqv
      421 qq
//
LOCUS       NP_001156976             474 aa            linear   ROD 09-OCT-2023
DEFINITION  bile acid receptor isoform 2 [Mus musculus].
ACCESSION   NP_001156976
VERSION     NP_001156976.1
DBSOURCE    REFSEQ: accession NM_001163504.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 474)
  AUTHORS   Xu Z, Huang Z, Zhang Y, Sun H, Hinz U, Heger U, Loos M, Gonzalez
            FJ, Hackert T, Bergmann F and Fortunato F.
  TITLE     Farnesoid X receptor activation inhibits pancreatic carcinogenesis
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1869 (7), 166811 (2023)
   PUBMED   37515840
REFERENCE   2  (residues 1 to 474)
  AUTHORS   Qiu Y, Kang N, Wang X, Yao Y, Cui J, Zhang X and Zheng L.
  TITLE     Loss of Farnesoid X receptor (FXR) accelerates dysregulated glucose
            and renal injury in db/db mice
  JOURNAL   PeerJ 11, e16155 (2023)
   PUBMED   37790634
  REMARK    GeneRIF: Loss of Farnesoid X receptor (FXR) accelerates
            dysregulated glucose and renal injury in db/db mice.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 474)
  AUTHORS   Dean AE, Jungwirth E, Panzitt K, Wagner M and Anakk S.
  TITLE     Hepatic farnesoid X receptor is necessary to facilitate ductular
            reaction and expression of heme biosynthetic genes
  JOURNAL   Hepatol Commun 7 (10), e0213 (2023)
   PUBMED   37695073
  REMARK    GeneRIF: Hepatic farnesoid X receptor is necessary to facilitate
            ductular reaction and expression of heme biosynthetic genes.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 474)
  AUTHORS   Li Z, Dong H, Bian S, Wu H, Song W, Jia X, Chen J, Zhu X, Zhao L,
            Xuan Z, Jin C, Zhou M, Zheng S and Song P.
  TITLE     FXR Maintains the Intestinal Barrier and Stemness by Regulating
            CYP11A1-Mediated Corticosterone Synthesis in Biliary Obstruction
            Diseases
  JOURNAL   Int J Mol Sci 24 (17), 13494 (2023)
   PUBMED   37686300
  REMARK    GeneRIF: FXR Maintains the Intestinal Barrier and Stemness by
            Regulating CYP11A1-Mediated Corticosterone Synthesis in Biliary
            Obstruction Diseases.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 474)
  AUTHORS   Song X, Zhang H, Zhang Y, Goh B, Bao B, Mello SS, Sun X, Zheng W,
            Gazzaniga FS, Wu M, Qu F, Yin Q, Gilmore MS, Oh SF and Kasper DL.
  TITLE     Gut microbial fatty acid isomerization modulates intraepithelial T
            cells
  JOURNAL   Nature 619 (7971), 837-843 (2023)
   PUBMED   37380774
REFERENCE   6  (residues 1 to 474)
  AUTHORS   Shih DQ, Bussen M, Sehayek E, Ananthanarayanan M, Shneider BL,
            Suchy FJ, Shefer S, Bollileni JS, Gonzalez FJ, Breslow JL and
            Stoffel M.
  TITLE     Hepatocyte nuclear factor-1alpha is an essential regulator of bile
            acid and plasma cholesterol metabolism
  JOURNAL   Nat Genet 27 (4), 375-382 (2001)
   PUBMED   11279518
REFERENCE   7  (residues 1 to 474)
  AUTHORS   Lammert F, Carey MC and Paigen B.
  TITLE     Chromosomal organization of candidate genes involved in cholesterol
            gallstone formation: a murine gallstone map
  JOURNAL   Gastroenterology 120 (1), 221-238 (2001)
   PUBMED   11208732
  REMARK    Review article
REFERENCE   8  (residues 1 to 474)
  AUTHORS   Sinal CJ, Tohkin M, Miyata M, Ward JM, Lambert G and Gonzalez FJ.
  TITLE     Targeted disruption of the nuclear receptor FXR/BAR impairs bile
            acid and lipid homeostasis
  JOURNAL   Cell 102 (6), 731-744 (2000)
   PUBMED   11030617
REFERENCE   9  (residues 1 to 474)
  AUTHORS   Kozak CA, Adamson MC and Weinberger C.
  TITLE     Genetic mapping of gene encoding the farnesoid receptor, Fxr, to
            mouse Chromosome 10
  JOURNAL   Mamm Genome 7 (2), 164-165 (1996)
   PUBMED   8835541
REFERENCE   10 (residues 1 to 474)
  AUTHORS   Seol W, Choi HS and Moore DD.
  TITLE     Isolation of proteins that interact specifically with the retinoid
            X receptor: two novel orphan receptors
  JOURNAL   Mol Endocrinol 9 (1), 72-85 (1995)
   PUBMED   7760852
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC152417.3.
            
            Transcript Variant: This variant (2), alternatively referred to as
            alpha 1, differs in the 5' UTR and 5' coding region and initiates
            translation at an alternate start codon, compared to variant 1. The
            encoded isoform (2) is shorter and has a distinct N-terminus
            compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U09417.1, U09418.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 44.98 cM"
     Protein         1..474
                     /product="bile acid receptor isoform 2"
                     /note="bile acid receptor; farnesoid X activated receptor;
                     RXR-interacting protein 14; retinoid X
                     receptor-interacting protein 14; farnesol receptor HRR-1"
                     /calculated_mol_wt=54308
     Region          121..208
                     /region_name="NR_DBD_FXR"
                     /note="DNA-binding domain of Farnesoid X receptor (FXR)
                     family is composed of two C4-type zinc fingers; cd06962"
                     /db_xref="CDD:143520"
     Site            order(124,127,141,144,160,166,176,179)
                     /site_type="other"
                     /note="zinc binding site [ion binding]"
                     /db_xref="CDD:143520"
     Site            order(129..130,170..171,174)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:143520"
     Site            order(133..136,142..143,145,147,149..150,173..175,177,180,
                     194)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143520"
     Region          250..469
                     /region_name="NR_LBD_Fxr"
                     /note="The ligand binding domain of Farnesoid X receptor:a
                     member of the nuclear receptor superfamily of
                     ligand-activated transcription factors; cd06936"
                     /db_xref="CDD:132734"
     Site            order(267,286,289..290,292..293,296,330..331,333..334,337,
                     449,463)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:132734"
     Site            order(298,301,305,315..316,319,322..323,466,469)
                     /site_type="other"
                     /note="coactivator recognition site [polypeptide binding]"
                     /db_xref="CDD:132734"
     Site            order(377,396,403,407,430,433..434,437..438,440,443..444,
                     447..448)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:132734"
     CDS             1..474
                     /gene="Nr1h4"
                     /gene_synonym="Fxr; HRR1; RIP14; Rxrip14"
                     /coded_by="NM_001163504.1:289..1713"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS48669.1"
                     /db_xref="GeneID:20186"
                     /db_xref="MGI:MGI:1352464"
ORIGIN      
        1 mnlighshlq atdefslses lfgmltehaa gplgqnldle syspynnvpf pqvqpqisss
       61 syysnlgfyp qqpedwyspg iyelrrmpae tgyqgetevs empvtkkprm aaasagrikg
      121 delcvvcgdr asgyhynalt cegckgffrr sitknavykc knggncvmdm ymrrkcqecr
      181 lrkckemgml aecmytgllt eiqckskrlr knvkqhadqt aneddsegrd lrqvtsttkf
      241 crekteltad qqtlldyimd synkqrmpqe itnkilkeef saeenflilt ematshvqil
      301 veftkklpgf qtldhedqia llkgsaveam flrsaeifnk klpaghadll eerirksgis
      361 deyitpmfsf yksvgelkmt qeeyalltai vilspdrqyi kdreaveklq eplldvlqkl
      421 ckmyqpenpq hfacllgrlt elrtfnhhha emlmswrvnd hkftpllcei wdvq
//
LOCUS       NP_035472                215 aa            linear   ROD 09-OCT-2023
DEFINITION  vesicle-trafficking protein SEC22b precursor [Mus musculus].
ACCESSION   NP_035472
VERSION     NP_035472.1
DBSOURCE    REFSEQ: accession NM_011342.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 215)
  AUTHORS   Tondeur EGM, Voerman JSA, Geleijnse MAA, van Hofwegen LS, van
            Krimpen A, Koerner J, Mishra G, Song Z and Schliehe C.
  TITLE     Sec22b and Stx4 Depletion Has No Major Effect on Cross-Presentation
            of PLGA Microsphere-Encapsulated Antigen and a Synthetic Long
            Peptide In Vitro
  JOURNAL   J Immunol 211 (8), 1203-1215 (2023)
   PUBMED   37638825
  REMARK    GeneRIF: Sec22b and Stx4 Depletion Has No Major Effect on
            Cross-Presentation of PLGA Microsphere-Encapsulated Antigen and a
            Synthetic Long Peptide In Vitro.
REFERENCE   2  (residues 1 to 215)
  AUTHORS   Biscari L, Maza MC, Farre C, Kaufman CD, Amigorena S, Fresno M,
            Girones N and Alloatti A.
  TITLE     Sec22b-dependent antigen cross-presentation is a significant
            contributor of T cell priming during infection with the parasite
            Trypanosoma cruzi
  JOURNAL   Front Cell Dev Biol 11, 1138571 (2023)
   PUBMED   36936692
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 215)
  AUTHORS   Bonaud A, Gargowitsch L, Gilbert SM, Rajan E, Canales-Herrerias P,
            Stockholm D, Rahman NF, Collins MO, Taskiran H, Hill DL, Alloatti
            A, Alouche N, Balor S, Soldan V, Gillet D, Barbier J, Bachelerie F,
            Smith KGC, Jellusova J, Bruhns P, Amigorena S, Balabanian K,
            Linterman MA, Peden AA and Espeli M.
  TITLE     Sec22b is a critical and nonredundant regulator of plasma cell
            maintenance
  JOURNAL   Proc Natl Acad Sci U S A 120 (2), e2213056120 (2023)
   PUBMED   36595686
  REMARK    GeneRIF: Sec22b is a critical and nonredundant regulator of plasma
            cell maintenance.
REFERENCE   4  (residues 1 to 215)
  AUTHORS   Arango Duque G, Dion R, Matte C, Fabie A, Descoteaux J, Stager S
            and Descoteaux A.
  TITLE     Sec22b Regulates Inflammatory Responses by Controlling the Nuclear
            Translocation of NF-kappaB and the Secretion of Inflammatory
            Mediators
  JOURNAL   J Immunol 207 (9), 2297-2309 (2021)
   PUBMED   34580108
  REMARK    GeneRIF: Sec22b Regulates Inflammatory Responses by Controlling the
            Nuclear Translocation of NF-kappaB and the Secretion of
            Inflammatory Mediators.
REFERENCE   5  (residues 1 to 215)
  AUTHORS   Wu SJ, Khoriaty R, Kim SH, O'Shea KS, Zhu G, Hoenerhoff M, Zajac C,
            Oravecz-Wilson K, Toubai T, Sun Y, Ginsburg D and Reddy P.
  TITLE     SNARE protein SEC22B regulates early embryonic development
  JOURNAL   Sci Rep 9 (1), 11434 (2019)
   PUBMED   31391476
  REMARK    GeneRIF: SNARE protein SEC22B regulates early embryonic
            development.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 215)
  AUTHORS   Jang SB, Kim YG, Cho YS, Suh PG, Kim KH and Oh BH.
  TITLE     Crystal structure of SEDL and its implications for a genetic
            disease spondyloepiphyseal dysplasia tarda
  JOURNAL   J Biol Chem 277 (51), 49863-49869 (2002)
   PUBMED   12361953
REFERENCE   7  (residues 1 to 215)
  AUTHORS   Gonzalez LC Jr, Weis WI and Scheller RH.
  TITLE     A novel snare N-terminal domain revealed by the crystal structure
            of Sec22b
  JOURNAL   J Biol Chem 276 (26), 24203-24211 (2001)
   PUBMED   11309394
REFERENCE   8  (residues 1 to 215)
  AUTHORS   Bell AW, Ward MA, Blackstock WP, Freeman HN, Choudhary JS, Lewis
            AP, Chotai D, Fazel A, Gushue JN, Paiement J, Palcy S, Chevet E,
            Lafreniere-Roula M, Solari R, Thomas DY, Rowley A and Bergeron JJ.
  TITLE     Proteomics characterization of abundant Golgi membrane proteins
  JOURNAL   J Biol Chem 276 (7), 5152-5165 (2001)
   PUBMED   11042173
REFERENCE   9  (residues 1 to 215)
  AUTHORS   Zhang T, Wong SH, Tang BL, Xu Y and Hong W.
  TITLE     Morphological and functional association of Sec22b/ERS-24 with the
            pre-Golgi intermediate compartment
  JOURNAL   Mol Biol Cell 10 (2), 435-453 (1999)
   PUBMED   9950687
REFERENCE   10 (residues 1 to 215)
  AUTHORS   Hay JC, Chao DS, Kuo CS and Scheller RH.
  TITLE     Protein interactions regulating vesicle transport between the
            endoplasmic reticulum and Golgi apparatus in mammalian cells
  JOURNAL   Cell 89 (1), 149-158 (1997)
   PUBMED   9094723
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC131746.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK037918.1, AK088514.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..215
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 42.35 cM"
     Protein         1..215
                     /product="vesicle-trafficking protein SEC22b precursor"
                     /note="vesicle-trafficking protein SEC22b; ERS24; mSec22b;
                     ER-Golgi SNARE of 24 kDa; SEC22 vesicle trafficking
                     protein-like 1; SEC22 vesicle trafficking protein homolog
                     B"
                     /calculated_mol_wt=23369
     sig_peptide     1..13
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=1390
     Region          3..126
                     /region_name="Longin"
                     /note="longin domain; cd14824"
                     /db_xref="CDD:341428"
     Site            order(3,33,36,56,59,61)
                     /site_type="lipid-binding"
                     /note="lipid binding site [chemical binding]"
                     /db_xref="CDD:341428"
     Site            order(15,18,20,34,38,117,121,124)
                     /site_type="other"
                     /note="Sec22 interface [polypeptide binding]"
                     /db_xref="CDD:341428"
     Site            38
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:O75396; propagated from
                     UniProtKB/Swiss-Prot (O08547.3)"
     Site            order(55,58,78,82)
                     /site_type="other"
                     /note="VARP interface [polypeptide binding]"
                     /db_xref="CDD:341428"
     Region          132..195
                     /region_name="R-SNARE_SEC22"
                     /note="SNARE motif of SEC22; cd15866"
                     /db_xref="CDD:277219"
     Site            order(134..136,138..139,141..146,148..150,152,155..156,
                     158..160,162..167,169..174,176..181,183..188,190..192)
                     /site_type="other"
                     /note="heterotetramer interface [polypeptide binding]"
                     /db_xref="CDD:277219"
     Site            137
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18630941,
                     ECO:0007744|PubMed:19144319, ECO:0007744|PubMed:21183079;
                     propagated from UniProtKB/Swiss-Prot (O08547.3)"
     Site            140
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:O75396; propagated from
                     UniProtKB/Swiss-Prot (O08547.3)"
     Site            159
                     /site_type="other"
                     /note="zero layer"
                     /db_xref="CDD:277219"
     Site            164
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75396; propagated from
                     UniProtKB/Swiss-Prot (O08547.3)"
     Site            168
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (O08547.3)"
     Site            174
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75396; propagated from
                     UniProtKB/Swiss-Prot (O08547.3)"
     Site            177
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75396; propagated from
                     UniProtKB/Swiss-Prot (O08547.3)"
     Site            195..215
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O08547.3)"
     CDS             1..215
                     /gene="Sec22b"
                     /gene_synonym="4930564D15Rik; ERS-24; Sec22l1"
                     /coded_by="NM_011342.4:120..767"
                     /db_xref="CCDS:CCDS17658.1"
                     /db_xref="GeneID:20333"
                     /db_xref="MGI:MGI:1338759"
ORIGIN      
        1 mvlltmiarv adglplaasm qedeqsgrdl qqyqsqakql frklneqspt rctleagamt
       61 fhyiieqgvc ylvlceaafp kklafayled lhsefdeqhg kkvptvsrpy sfiefdtfiq
      121 ktkklyidsr arrnlgsint elqdvqrimv anieevlqrg ealsaldska nnlsslskky
      181 rqdakylnmr styaklaava vffimlivyv rfwwl
//
LOCUS       NP_001280551             511 aa            linear   ROD 09-OCT-2023
DEFINITION  protein phosphatase 3 catalytic subunit alpha isoform 2 [Mus
            musculus].
ACCESSION   NP_001280551 XP_006501199
VERSION     NP_001280551.1
DBSOURCE    REFSEQ: accession NM_001293622.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 511)
  AUTHORS   Wan X, Zhao S, Dai Y, Zhang J, Shen Y, Gong L and Le Q.
  TITLE     WNT16b promotes the proliferation and self-renewal of human limbal
            epithelial stem/progenitor cells via activating the
            calcium/calcineurin A/NFATC2 pathway
  JOURNAL   Cell Prolif 56 (10), e13460 (2023)
   PUBMED   36974338
  REMARK    GeneRIF: WNT16b promotes the proliferation and self-renewal of
            human limbal epithelial stem/progenitor cells via activating the
            calcium/calcineurin A/NFATC2 pathway.
REFERENCE   2  (residues 1 to 511)
  AUTHORS   Delint-Ramirez I, Konada L, Heady L, Rueda R, Jacome ASV, Marlin E,
            Marchioni C, Segev A, Kritskiy O, Yamakawa S, Reiter AH, Tsai LH
            and Madabhushi R.
  TITLE     Calcineurin dephosphorylates topoisomerase IIbeta and regulates the
            formation of neuronal-activity-induced DNA breaks
  JOURNAL   Mol Cell 82 (20), 3794-3809 (2022)
   PUBMED   36206766
  REMARK    GeneRIF: Calcineurin dephosphorylates topoisomerase IIbeta and
            regulates the formation of neuronal-activity-induced DNA breaks.
REFERENCE   3  (residues 1 to 511)
  AUTHORS   Miura E and Watanabe M.
  TITLE     Coexpression of calcineurin A and B subunits in various subcellular
            and synaptic compartments of cerebellar neurons and glia with
            particular abundance at parallel fiber-Purkinje cell synapses
  JOURNAL   Neurosci Res 180, 13-22 (2022)
   PUBMED   35247520
  REMARK    GeneRIF: Coexpression of calcineurin A and B subunits in various
            subcellular and synaptic compartments of cerebellar neurons and
            glia with particular abundance at parallel fiber-Purkinje cell
            synapses.
REFERENCE   4  (residues 1 to 511)
  AUTHORS   Bedogni F and Hevner RF.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 511)
  AUTHORS   Sidoli M, Reed CB, Scapin C, Paez P, Cavener DR, Kaufman RJ,
            D'Antonio M, Feltri ML and Wrabetz L.
  TITLE     Calcineurin Activity Is Increased in Charcot-Marie-Tooth 1B
            Demyelinating Neuropathy
  JOURNAL   J Neurosci 41 (20), 4536-4548 (2021)
   PUBMED   33879538
REFERENCE   6  (residues 1 to 511)
  AUTHORS   Gaestel M, Benndorf R, Hayess K, Priemer E and Engel K.
  TITLE     Dephosphorylation of the small heat shock protein hsp25 by
            calcium/calmodulin-dependent (type 2B) protein phosphatase
  JOURNAL   J Biol Chem 267 (30), 21607-21611 (1992)
   PUBMED   1328240
REFERENCE   7  (residues 1 to 511)
  AUTHORS   Giri PR, Marietta CA, Higuchi S and Kincaid RL.
  TITLE     Molecular and phylogenetic analysis of calmodulin-dependent protein
            phosphatase (calcineurin) catalytic subunit genes
  JOURNAL   DNA Cell Biol 11 (5), 415-424 (1992)
   PUBMED   1318721
REFERENCE   8  (residues 1 to 511)
  AUTHORS   Kincaid RL, Giri PR, Higuchi S, Tamura J, Dixon SC, Marietta CA,
            Amorese DA and Martin BM.
  TITLE     Cloning and characterization of molecular isoforms of the catalytic
            subunit of calcineurin using nonisotopic methods
  JOURNAL   J Biol Chem 265 (19), 11312-11319 (1990)
   PUBMED   2162844
REFERENCE   9  (residues 1 to 511)
  AUTHORS   Guerini D and Klee CB.
  TITLE     Cloning of human calcineurin A: evidence for two isozymes and
            identification of a polyproline structural domain
  JOURNAL   Proc Natl Acad Sci U S A 86 (23), 9183-9187 (1989)
   PUBMED   2556704
REFERENCE   10 (residues 1 to 511)
  AUTHORS   Kincaid RL, Nightingale MS and Martin BM.
  TITLE     Characterization of a cDNA clone encoding the calmodulin-binding
            domain of mouse brain calcineurin
  JOURNAL   Proc Natl Acad Sci U S A 85 (23), 8983-8987 (1988)
   PUBMED   2848250
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116384.9, AK150393.1, AK053582.1, AC129775.4 and AI835974.1.
            
            On Jun 11, 2014 this sequence version replaced XP_006501199.1.
            
            Transcript Variant: This variant (2) lacks an in-frame exon in the
            3' coding region compared to variant 1. The encoded isoform (2) is
            shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146387.1, AK150393.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..511
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 63.34 cM"
     Protein         1..511
                     /product="protein phosphatase 3 catalytic subunit alpha
                     isoform 2"
                     /EC_number="3.1.3.16"
                     /note="calcineurin A alpha; protein phosphatase 3
                     catalytic subunit alpha; CAM-PRP catalytic subunit; PP2BA
                     alpha; PP2B alpha 1; CNA alpha"
                     /calculated_mol_wt=57484
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylserine.
                     /evidence=ECO:0000250|UniProtKB:Q08209; propagated from
                     UniProtKB/Swiss-Prot (P63328.1)"
     Region          41..345
                     /region_name="MPP_PP2B"
                     /note="PP2B, metallophosphatase domain; cd07416"
                     /db_xref="CDD:277361"
     Site            order(53,55,90,92,118,150,159,199,281,314,341)
                     /site_type="other"
                     /note="CN-CyPA-CsA complex [polypeptide binding]"
                     /db_xref="CDD:277361"
     Region          56..340
                     /region_name="Catalytic. /evidence=ECO:0000305"
                     /note="propagated from UniProtKB/Swiss-Prot (P63328.1)"
     Site            order(90,92,118,122,150..151,199,232,254,281,283)
                     /site_type="active"
                     /db_xref="CDD:277361"
     Site            order(90,92,118,150,199,281)
                     /site_type="metal-binding"
                     /note="metal binding site [ion binding]"
                     /db_xref="CDD:277361"
     Region          307..311
                     /region_name="SAPNY motif.
                     /evidence=ECO:0000250|UniProtKB:Q08209"
                     /note="propagated from UniProtKB/Swiss-Prot (P63328.1)"
     Region          327..336
                     /region_name="Interaction with PxIxIF motif in substrate.
                     /evidence=ECO:0000250|UniProtKB:Q08209"
                     /note="propagated from UniProtKB/Swiss-Prot (P63328.1)"
     Region          341..369
                     /region_name="Calcineurin B binding.
                     /evidence=ECO:0000269|PubMed:26794871"
                     /note="propagated from UniProtKB/Swiss-Prot (P63328.1)"
     Site            352
                     /site_type="other"
                     /note="Interaction with PxVP motif in substrate.
                     /evidence=ECO:0000250|UniProtKB:Q08209; propagated from
                     UniProtKB/Swiss-Prot (P63328.1)"
     Region          392..406
                     /region_name="Calmodulin-binding.
                     /evidence=ECO:0000269|PubMed:26794871"
                     /note="propagated from UniProtKB/Swiss-Prot (P63328.1)"
     Region          407..414
                     /region_name="Autoinhibitory segment.
                     /evidence=ECO:0000269|PubMed:26794871"
                     /note="propagated from UniProtKB/Swiss-Prot (P63328.1)"
     Region          455..477
                     /region_name="Autoinhibitory domain.
                     /evidence=ECO:0000269|PubMed:26794871"
                     /note="propagated from UniProtKB/Swiss-Prot (P63328.1)"
     Site            459
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P63329; propagated from
                     UniProtKB/Swiss-Prot (P63328.1)"
     Region          465..511
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P63328.1)"
     Site            482
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P63328.1)"
     CDS             1..511
                     /gene="Ppp3ca"
                     /gene_synonym="2900074D19Rik; Caln; Calna; CN; CnA"
                     /coded_by="NM_001293622.1:779..2314"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS80027.1"
                     /db_xref="GeneID:19055"
                     /db_xref="MGI:MGI:107164"
ORIGIN      
        1 msepkaidpk lsttdrvvka vpfppshrlt akevfdndgk prvdilkahl mkegrleesv
       61 alriitegas ilrqeknlld idapvtvcgd ihgqffdlmk lfevggspan trylflgdyv
      121 drgyfsiecv lylwalkily pktlfllrgn hecrhlteyf tfkqeckiky servydacmd
      181 afdclplaal mnqqflcvhg glspeintld dirkldrfke ppaygpmcdi lwsdpledfg
      241 nektqehfth ntvrgcsyfy sypavcdflq hnnllsilra heaqdagyrm yrksqttgfp
      301 slitifsapn yldvynnkaa vlkyennvmn irqfncsphp ywlpnfmdvf twslpfvgek
      361 vtemlvnvln icsddelgse edgfdgataa arkevirnki raigkmarvf svlreesesv
      421 ltlkgltptg mlpsgvlsgg kqtlqsaikg fspqhkitsf eeakgldrin ermpprrdam
      481 psdanlnsin kalasetngt dsngsnssni q
//
LOCUS       NP_001278107             477 aa            linear   ROD 09-OCT-2023
DEFINITION  nuclear factor of activated T-cells, cytoplasmic 2 isoform j [Mus
            musculus].
ACCESSION   NP_001278107
VERSION     NP_001278107.1
DBSOURCE    REFSEQ: accession NM_001291178.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 477)
  AUTHORS   Fu Y, Wang J, Liu C, Liao K, Gao X, Tang R, Fan B, Hong Y, Xiao N,
            Xiao C and Liu WH.
  TITLE     Glycogen synthase kinase 3 controls T-cell exhaustion by regulating
            NFAT activation
  JOURNAL   Cell Mol Immunol 20 (10), 1127-1139 (2023)
   PUBMED   37553428
  REMARK    GeneRIF: Glycogen synthase kinase 3 controls T-cell exhaustion by
            regulating NFAT activation.
REFERENCE   2  (residues 1 to 477)
  AUTHORS   Wan X, Zhao S, Dai Y, Zhang J, Shen Y, Gong L and Le Q.
  TITLE     WNT16b promotes the proliferation and self-renewal of human limbal
            epithelial stem/progenitor cells via activating the
            calcium/calcineurin A/NFATC2 pathway
  JOURNAL   Cell Prolif 56 (10), e13460 (2023)
   PUBMED   36974338
  REMARK    GeneRIF: WNT16b promotes the proliferation and self-renewal of
            human limbal epithelial stem/progenitor cells via activating the
            calcium/calcineurin A/NFATC2 pathway.
REFERENCE   3  (residues 1 to 477)
  AUTHORS   Jiang F, Guo Y, Hu L, Zhang M, Meng J, Si Y and Shi H.
  TITLE     Role of nuclear factor of activated T Cells-1 in Sepsis-induced
            behavioral deficits in mice
  JOURNAL   Brain Res 1806, 148299 (2023)
   PUBMED   36842570
REFERENCE   4  (residues 1 to 477)
  AUTHORS   Nagai J, Lin J and Boyce JA.
  TITLE     Macrophage P2Y6 Receptor Signaling Selectively Activates NFATC2 and
            Suppresses Allergic Lung Inflammation
  JOURNAL   J Immunol 209 (12), 2293-2303 (2022)
   PUBMED   36307120
  REMARK    GeneRIF: Macrophage P2Y6 Receptor Signaling Selectively Activates
            NFATC2 and Suppresses Allergic Lung Inflammation.
REFERENCE   5  (residues 1 to 477)
  AUTHORS   Zhu L, Zhou X, Gu M, Kim J, Li Y, Ko CJ, Xie X, Gao T, Cheng X and
            Sun SC.
  TITLE     Dapl1 controls NFATc2 activation to regulate CD8+ T cell exhaustion
            and responses in chronic infection and cancer
  JOURNAL   Nat Cell Biol 24 (7), 1165-1176 (2022)
   PUBMED   35773432
REFERENCE   6  (residues 1 to 477)
  AUTHORS   Vihma H, Pruunsild P and Timmusk T.
  TITLE     Alternative splicing and expression of human and mouse NFAT genes
  JOURNAL   Genomics 92 (5), 279-291 (2008)
   PUBMED   18675896
REFERENCE   7  (residues 1 to 477)
  AUTHORS   Ho SN, Thomas DJ, Timmerman LA, Li X, Francke U and Crabtree GR.
  TITLE     NFATc3, a lymphoid-specific NFATc family member that is
            calcium-regulated and exhibits distinct DNA binding specificity
  JOURNAL   J Biol Chem 270 (34), 19898-19907 (1995)
   PUBMED   7650004
REFERENCE   8  (residues 1 to 477)
  AUTHORS   Jain J, Burgeon E, Badalian TM, Hogan PG and Rao A.
  TITLE     A similar DNA-binding motif in NFAT family proteins and the Rel
            homology region
  JOURNAL   J Biol Chem 270 (8), 4138-4145 (1995)
   PUBMED   7876165
REFERENCE   9  (residues 1 to 477)
  AUTHORS   Li X, Ho SN, Luna J, Giacalone J, Thomas DJ, Timmerman LA, Crabtree
            GR and Francke U.
  TITLE     Cloning and chromosomal localization of the human and murine genes
            for the T-cell transcription factors NFATc and NFATp
  JOURNAL   Cytogenet Cell Genet 68 (3-4), 185-191 (1995)
   PUBMED   7842733
REFERENCE   10 (residues 1 to 477)
  AUTHORS   Ho AM, Jain J, Rao A and Hogan PG.
  TITLE     Expression of the transcription factor NFATp in a neuronal cell
            line and in the murine nervous system
  JOURNAL   J Biol Chem 269 (45), 28181-28186 (1994)
   PUBMED   7961754
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK135414.1, EU887592.1, EU887581.1 and BP757417.1.
            
            Transcript Variant: This variant (15, also known as
            IB-deltaII-deltaXa) contains alternate 5' exon structure, and it
            thus differs in the 5' UTR and initiates translation at a
            downstream in-frame start codon, compared to variant 1. The encoded
            isoform (j) is shorter at the N-terminus, compared to isoform a.
            Both variants 10 and 15 encode isoform j.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU887592.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 88.91 cM"
     Protein         1..477
                     /product="nuclear factor of activated T-cells, cytoplasmic
                     2 isoform j"
                     /note="nuclear factor of activated T-cells, cytoplasmic 2;
                     NFAT pre-existing subunit; T-cell transcription factor
                     NFAT1"
                     /calculated_mol_wt=52558
     Region          <1..124
                     /region_name="RHD-n"
                     /note="N-terminal sub-domain of the Rel homology domain
                     (RHD); cl08275"
                     /db_xref="CDD:447596"
     Region          129..229
                     /region_name="IPT_NFAT"
                     /note="IPT domain of the NFAT family of transcription
                     factors. NFAT transcription complexes are a target of
                     calcineurin, a calcium dependent phosphatase, and activate
                     genes mainly involved in cell-cell-interaction; cd01178"
                     /db_xref="CDD:238583"
     Site            order(153,217)
                     /site_type="DNA binding"
                     /note="DNA binding sites [nucleotide binding]"
                     /db_xref="CDD:238583"
     CDS             1..477
                     /gene="Nfatc2"
                     /gene_synonym="NF-ATc2; NF-ATp; NFAT1; NFAT1-D; Nfatp"
                     /coded_by="NM_001291178.1:489..1922"
                     /note="isoform j is encoded by transcript variant 15"
                     /db_xref="GeneID:18019"
                     /db_xref="MGI:MGI:102463"
ORIGIN      
        1 menkplglqi figtaderil kphafyqvhr itgktvttts yekivgntkv leiplepknn
       61 mratidcagi lklrnadiel rkgetdigrk ntrvrlvfrv hvpepsgriv slqaasnpie
      121 csqrsahelp mverqdmdsc lvyggqqmil tgqnftaesk vvfmekttdg qqiwemeatv
      181 dkdksqpnml fveipeyrnk hirvpvkvnf yvingkrkrs qpqhftyhpv paiktepsde
      241 yepslicspa hgglgsqpyy pqhpmlaesp sclvatmapc qqfrsglssp daryqqqspa
      301 aalyqrsksl spgllgyqqp sllaaplgla dahrsvlvha gsqgqgqgst lphtssasqq
      361 aspvihyspt nqqlrggghq efqhimycen fgpssarpgp ppinqgqrls pgayptviqq
      421 qtapsqraak ngpsdqkeal ptgvtvkqeq nldqtylddv neiirkefsg ppsrnqt
//
LOCUS       NP_083922                219 aa            linear   ROD 09-OCT-2023
DEFINITION  interleukin-34 isoform 2 precursor [Mus musculus].
ACCESSION   NP_083922 XP_001003927 XP_001003931
VERSION     NP_083922.1
DBSOURCE    REFSEQ: accession NM_029646.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 219)
  AUTHORS   Ho A, Ngala B, Yamada C, Garcia C, Duarte C, Akkaoui J, Ciolac D,
            Nusbaum A, Kochen W, Efremova D, Groppa S, Nathanson L, Bissel S,
            Oblak A, Kacena MA and Movila A.
  TITLE     IL-34 exacerbates pathogenic features of Alzheimer's disease and
            calvaria osteolysis in triple transgenic (3x-Tg) female mice
  JOURNAL   Biomed Pharmacother 166, 115435 (2023)
   PUBMED   37666180
  REMARK    GeneRIF: IL-34 exacerbates pathogenic features of Alzheimer's
            disease and calvaria osteolysis in triple transgenic (3x-Tg) female
            mice.
REFERENCE   2  (residues 1 to 219)
  AUTHORS   Zhuang L, Zong X, Yang Q, Fan Q and Tao R.
  TITLE     Interleukin-34-NF-kappaB signaling aggravates myocardial
            ischemic/reperfusion injury by facilitating macrophage recruitment
            and polarization
  JOURNAL   EBioMedicine 95, 104744 (2023)
   PUBMED   37556943
  REMARK    GeneRIF: Interleukin-34-NF-kappaB signaling aggravates myocardial
            ischemic/reperfusion injury by facilitating macrophage recruitment
            and polarization.
REFERENCE   3  (residues 1 to 219)
  AUTHORS   Xie X, Zhang W, Xiao M, Wei T, Qiu Y, Qiu J, Wang H, Qiu Z, Zhang
            S, Pan Y, Mao L, Li Y, Guo B, Yang W, Hu Y, Hu S, Gong Y, Yang J,
            Xiao G, Zhang Y and Bai X.
  TITLE     TREM2 acts as a receptor for IL-34 to suppress acute myeloid
            leukemia in mice
  JOURNAL   Blood 141 (26), 3184-3198 (2023)
   PUBMED   37001042
  REMARK    GeneRIF: TREM2 acts as a receptor for IL-34 to suppress acute
            myeloid leukemia in mice.
REFERENCE   4  (residues 1 to 219)
  AUTHORS   Chae DS, Han S, Lee MK and Kim SW.
  TITLE     BMP-2 Genome-Edited Human MSCs Protect against Cartilage
            Degeneration via Suppression of IL-34 in Collagen-Induced Arthritis
  JOURNAL   Int J Mol Sci 24 (9), 8223 (2023)
   PUBMED   37175932
  REMARK    GeneRIF: BMP-2 Genome-Edited Human MSCs Protect against Cartilage
            Degeneration via Suppression of IL-34 in Collagen-Induced
            Arthritis.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 219)
  AUTHORS   Su Y, Cao Y, Liu C, Xu Q, Li N, Lan M, Li L, Wang K, Zhang Z and
            Meng Q.
  TITLE     Inactivating IL34 promotes regenerating muscle stem cell expansion
            and attenuates Duchenne muscular dystrophy in mouse models
  JOURNAL   Theranostics 13 (8), 2588-2604 (2023)
   PUBMED   37215564
  REMARK    GeneRIF: Inactivating IL34 promotes regenerating muscle stem cell
            expansion and attenuates Duchenne muscular dystrophy in mouse
            models.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 219)
  AUTHORS   Chen Z, Buki K, Vaaraniemi J, Gu G and Vaananen HK.
  TITLE     The critical role of IL-34 in osteoclastogenesis
  JOURNAL   PLoS One 6 (4), e18689 (2011)
   PUBMED   21494622
  REMARK    GeneRIF: This study was to explore the biological function,
            specifically osteoclastogenesis and bone metabolism, of il-34.
            Publication Status: Online-Only
REFERENCE   7  (residues 1 to 219)
  AUTHORS   Chihara T, Suzu S, Hassan R, Chutiwitoonchai N, Hiyoshi M,
            Motoyoshi K, Kimura F and Okada S.
  TITLE     IL-34 and M-CSF share the receptor Fms but are not identical in
            biological activity and signal activation
  JOURNAL   Cell Death Differ 17 (12), 1917-1927 (2010)
   PUBMED   20489731
REFERENCE   8  (residues 1 to 219)
  AUTHORS   Wei S, Nandi S, Chitu V, Yeung YG, Yu W, Huang M, Williams LT, Lin
            H and Stanley ER.
  TITLE     Functional overlap but differential expression of CSF-1 and IL-34
            in their CSF-1 receptor-mediated regulation of myeloid cells
  JOURNAL   J Leukoc Biol 88 (3), 495-505 (2010)
   PUBMED   20504948
  REMARK    GeneRIF: The different spatiotemporal expression of IL-34 and CSF-1
            allows for complementary activation of the CSF-1R in developing and
            adult tissues.
REFERENCE   9  (residues 1 to 219)
  AUTHORS   Baud'huin M, Renault R, Charrier C, Riet A, Moreau A, Brion R,
            Gouin F, Duplomb L and Heymann D.
  TITLE     Interleukin-34 is expressed by giant cell tumours of bone and plays
            a key role in RANKL-induced osteoclastogenesis
  JOURNAL   J Pathol 221 (1), 77-86 (2010)
   PUBMED   20191615
REFERENCE   10 (residues 1 to 219)
  AUTHORS   Lin H, Lee E, Hestir K, Leo C, Huang M, Bosch E, Halenbeck R, Wu G,
            Zhou A, Behrens D, Hollenbaugh D, Linnemann T, Qin M, Wong J, Chu
            K, Doberstein SK and Williams LT.
  TITLE     Discovery of a cytokine and its receptor by functional screening of
            the extracellular proteome
  JOURNAL   Science 320 (5877), 807-811 (2008)
   PUBMED   18467591
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY148512.1, AK008082.1 and AW743837.1.
            
            On or before May 4, 2006 this sequence version replaced
            XP_001003931.1, XP_001003927.1.
            
            Transcript Variant: This variant (2) contains an alternate exon in
            the 3' coding region which results in a novel 3' coding region and
            3' UTR, compared to variant 1. It encodes isoform 2 which is
            shorter and has a distinct C-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK008082.1, SRR12282455.12957500.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..219
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 57.68 cM"
     Protein         1..219
                     /product="interleukin-34 isoform 2 precursor"
                     /calculated_mol_wt=22549
     sig_peptide     1..20
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=2205
     Region          28..>153
                     /region_name="IL34"
                     /note="Interleukin 34; pfam15036"
                     /db_xref="CDD:434409"
     CDS             1..219
                     /gene="Il34"
                     /gene_synonym="2010004A03Rik"
                     /coded_by="NM_029646.3:584..1243"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2"
                     /db_xref="CCDS:CCDS52670.1"
                     /db_xref="GeneID:76527"
                     /db_xref="MGI:MGI:1923777"
ORIGIN      
        1 mpwglawlyc lgilldvalg nenleiwtlt qdkecdltgy lrgklqyknr lqymkhyfpi
       61 nyriavpyeg vlrvanitrl qkahvserel rylwvlvsln atesvmdvll eghpswkylq
      121 evqtllenvq rslmavgvhl pghvlvtlls qlpglpspwa rsfdtswell mmkgcgdwps
      181 rgscvissey srpkpeagaa qslagqllpg hgtavlfll
//
LOCUS       NP_001348623             503 aa            linear   ROD 09-OCT-2023
DEFINITION  nuclear respiratory factor 1 isoform a [Mus musculus].
ACCESSION   NP_001348623 XP_017176933
VERSION     NP_001348623.1
DBSOURCE    REFSEQ: accession NM_001361694.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 503)
  AUTHORS   Cheng C, Tian Y, Yang R, Guo W, Xiao K, Zhang F, Tian J, Deng Z,
            Yang W, Yang H and Zhou Z.
  TITLE     miR-5581 Contributes to Osteoarthritis by Targeting NRF1 to Disturb
            the Proliferation and Functions of Chondrocytes
  JOURNAL   Am J Pathol 193 (9), 1234-1247 (2023)
   PUBMED   37611970
  REMARK    GeneRIF: miR-5581 Contributes to Osteoarthritis by Targeting NRF1
            to Disturb the Proliferation and Functions of Chondrocytes.
REFERENCE   2  (residues 1 to 503)
  AUTHORS   Meng Z, Liang B, Wu Y, Liu C, Wang H, Du Y, Gan L, Gao E, Lau WB,
            Christopher TA, Lopez BL, Koch WJ, Ma X, Zhao F, Wang Y and Zhao J.
  TITLE     Hypoadiponectinemia-induced upregulation of microRNA449b
            downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury
            in diabetic mice
  JOURNAL   J Mol Cell Cardiol 182, 1-14 (2023)
   PUBMED   37437402
  REMARK    GeneRIF: Hypoadiponectinemia-induced upregulation of microRNA449b
            downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury
            in diabetic mice.
REFERENCE   3  (residues 1 to 503)
  AUTHORS   Zhao T, Zhang J, Lei H, Meng Y, Cheng H, Zhao Y, Geng G, Mu C, Chen
            L, Liu Q, Luo Q, Zhang C, Long Y, Su J, Wang Y, Li Z, Sun J, Chen
            G, Li Y, Liao X, Shang Y, Hu G, Chen Q and Zhu Y.
  TITLE     NRF1-mediated mitochondrial biogenesis antagonizes innate antiviral
            immunity
  JOURNAL   EMBO J 42 (16), e113258 (2023)
   PUBMED   37409632
  REMARK    GeneRIF: NRF1-mediated mitochondrial biogenesis antagonizes innate
            antiviral immunity.
REFERENCE   4  (residues 1 to 503)
  AUTHORS   Akl MG, Baccetto R, Stebbings BM, Li L and Widenmaier SB.
  TITLE     Euglycemia is affected by stress defense factor hepatocyte NRF1,
            but not NRF2
  JOURNAL   Biochem Biophys Res Commun 668, 96-103 (2023)
   PUBMED   37245295
  REMARK    GeneRIF: Euglycemia is affected by stress defense factor hepatocyte
            NRF1, but not NRF2.
REFERENCE   5  (residues 1 to 503)
  AUTHORS   Akl MG, Li L, Baccetto R, Phanse S, Zhang Q, Trites MJ, McDonald S,
            Aoki H, Babu M and Widenmaier SB.
  TITLE     Complementary gene regulation by NRF1 and NRF2 protects against
            hepatic cholesterol overload
  JOURNAL   Cell Rep 42 (4), 112399 (2023)
   PUBMED   37060561
  REMARK    GeneRIF: Complementary gene regulation by NRF1 and NRF2 protects
            against hepatic cholesterol overload.
            Erratum:[Cell Rep. 2023 Jul 25;42(7):112872. PMID: 37454293]
REFERENCE   6  (residues 1 to 503)
  AUTHORS   Carmona MC, Iglesias R, Obregon MJ, Darlington GJ, Villarroya F and
            Giralt M.
  TITLE     Mitochondrial biogenesis and thyroid status maturation in brown fat
            require CCAAT/enhancer-binding protein alpha
  JOURNAL   J Biol Chem 277 (24), 21489-21498 (2002)
   PUBMED   11940593
REFERENCE   7  (residues 1 to 503)
  AUTHORS   Huo L and Scarpulla RC.
  TITLE     Mitochondrial DNA instability and peri-implantation lethality
            associated with targeted disruption of nuclear respiratory factor 1
            in mice
  JOURNAL   Mol Cell Biol 21 (2), 644-654 (2001)
   PUBMED   11134350
REFERENCE   8  (residues 1 to 503)
  AUTHORS   Schaefer L, Engman H and Miller JB.
  TITLE     Coding sequence, chromosomal localization, and expression pattern
            of Nrf1: the mouse homolog of Drosophila erect wing
  JOURNAL   Mamm Genome 11 (2), 104-110 (2000)
   PUBMED   10656923
REFERENCE   9  (residues 1 to 503)
  AUTHORS   Huo L and Scarpulla RC.
  TITLE     Multiple 5'-untranslated exons in the nuclear respiratory factor 1
            gene span 47 kb and contribute to transcript heterogeneity and
            translational efficiency
  JOURNAL   Gene 233 (1-2), 213-224 (1999)
   PUBMED   10375638
REFERENCE   10 (residues 1 to 503)
  AUTHORS   Virbasius CA, Virbasius JV and Scarpulla RC.
  TITLE     NRF-1, an activator involved in nuclear-mitochondrial interactions,
            utilizes a new DNA-binding domain conserved in a family of
            developmental regulators
  JOURNAL   Genes Dev 7 (12A), 2431-2445 (1993)
   PUBMED   8253388
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153632.2.
            
            On Mar 29, 2018 this sequence version replaced XP_017176933.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.142474.1,
                                           SRR1660819.192556.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849390
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 12.47 cM"
     Protein         1..503
                     /product="nuclear respiratory factor 1 isoform a"
                     /note="NRF-1; alpha-pal; alpha palindromic-binding
                     protein"
                     /calculated_mol_wt=53440
     Region          1..78
                     /region_name="Dimerization. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU00.2)"
     Region          36..57
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU00.2)"
     Site            39
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:Q16656; propagated from
                     UniProtKB/Swiss-Prot (Q9WU00.2)"
     Site            44
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:Q16656; propagated from
                     UniProtKB/Swiss-Prot (Q9WU00.2)"
     Site            46
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:Q16656; propagated from
                     UniProtKB/Swiss-Prot (Q9WU00.2)"
     Site            47
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:Q16656; propagated from
                     UniProtKB/Swiss-Prot (Q9WU00.2)"
     Site            52
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:Q16656; propagated from
                     UniProtKB/Swiss-Prot (Q9WU00.2)"
     Region          87..283
                     /region_name="Nrf1_DNA-bind"
                     /note="NLS-binding and DNA-binding and dimerization
                     domains of Nrf1; pfam10491"
                     /db_xref="CDD:402218"
     Region          88..116
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU00.2)"
     Region          301..476
                     /region_name="Required for transcriptional activation.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU00.2)"
     Region          450..502
                     /region_name="Nrf1_activ_bdg"
                     /note="Nrf1 activator activation site binding domain;
                     pfam10492"
                     /db_xref="CDD:431313"
     CDS             1..503
                     /gene="Nrf1"
                     /gene_synonym="D6Ertd415e"
                     /coded_by="NM_001361694.2:1818..3329"
                     /note="isoform a is encoded by transcript variant 9"
                     /db_xref="CCDS:CCDS19968.1"
                     /db_xref="GeneID:18181"
                     /db_xref="MGI:MGI:1332235"
ORIGIN      
        1 meehgvtqte hmatieahav aqqvqqvhva tytehsmlsa dedspssped tsyddsdiln
       61 staadevtah laaagpvgma aaaavatgkk rkrphvfesn psirkrqqtr llrklratld
      121 eyttrvgqqa ivlcispskp npvfkvfgaa plenvvrkyk smiledlesa laehapapqe
      181 vnselpplti dgipvsvdkm tqaqlrafip emlkystgrg kpgwgkesck piwwpedipw
      241 anvrsdvrte eqkqrvswtq alrtivkncy kqhgredlly afedqqtqtq attthsiahl
      301 vpsqtvvqtf snpdgtvsli qvgtgatvat ladaselptt vtvaqvnysa vadgeveqnw
      361 atlqggemti qttqaseatq avaslaeaav aasqemqqga tvtmalnsea aahavatlae
      421 atlqgggqiv lsgetaaavg altgvqdang lvqipvsmyq tvvtslaqgn gpvqvamapv
      481 ttrisdsavt mdgqavevvt leq
//
LOCUS       NP_001157699             534 aa            linear   ROD 09-OCT-2023
DEFINITION  nuclear respiratory factor 1 isoform b [Mus musculus].
ACCESSION   NP_001157699
VERSION     NP_001157699.1
DBSOURCE    REFSEQ: accession NM_001164227.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 534)
  AUTHORS   Cheng C, Tian Y, Yang R, Guo W, Xiao K, Zhang F, Tian J, Deng Z,
            Yang W, Yang H and Zhou Z.
  TITLE     miR-5581 Contributes to Osteoarthritis by Targeting NRF1 to Disturb
            the Proliferation and Functions of Chondrocytes
  JOURNAL   Am J Pathol 193 (9), 1234-1247 (2023)
   PUBMED   37611970
  REMARK    GeneRIF: miR-5581 Contributes to Osteoarthritis by Targeting NRF1
            to Disturb the Proliferation and Functions of Chondrocytes.
REFERENCE   2  (residues 1 to 534)
  AUTHORS   Meng Z, Liang B, Wu Y, Liu C, Wang H, Du Y, Gan L, Gao E, Lau WB,
            Christopher TA, Lopez BL, Koch WJ, Ma X, Zhao F, Wang Y and Zhao J.
  TITLE     Hypoadiponectinemia-induced upregulation of microRNA449b
            downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury
            in diabetic mice
  JOURNAL   J Mol Cell Cardiol 182, 1-14 (2023)
   PUBMED   37437402
  REMARK    GeneRIF: Hypoadiponectinemia-induced upregulation of microRNA449b
            downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury
            in diabetic mice.
REFERENCE   3  (residues 1 to 534)
  AUTHORS   Zhao T, Zhang J, Lei H, Meng Y, Cheng H, Zhao Y, Geng G, Mu C, Chen
            L, Liu Q, Luo Q, Zhang C, Long Y, Su J, Wang Y, Li Z, Sun J, Chen
            G, Li Y, Liao X, Shang Y, Hu G, Chen Q and Zhu Y.
  TITLE     NRF1-mediated mitochondrial biogenesis antagonizes innate antiviral
            immunity
  JOURNAL   EMBO J 42 (16), e113258 (2023)
   PUBMED   37409632
  REMARK    GeneRIF: NRF1-mediated mitochondrial biogenesis antagonizes innate
            antiviral immunity.
REFERENCE   4  (residues 1 to 534)
  AUTHORS   Akl MG, Baccetto R, Stebbings BM, Li L and Widenmaier SB.
  TITLE     Euglycemia is affected by stress defense factor hepatocyte NRF1,
            but not NRF2
  JOURNAL   Biochem Biophys Res Commun 668, 96-103 (2023)
   PUBMED   37245295
  REMARK    GeneRIF: Euglycemia is affected by stress defense factor hepatocyte
            NRF1, but not NRF2.
REFERENCE   5  (residues 1 to 534)
  AUTHORS   Akl MG, Li L, Baccetto R, Phanse S, Zhang Q, Trites MJ, McDonald S,
            Aoki H, Babu M and Widenmaier SB.
  TITLE     Complementary gene regulation by NRF1 and NRF2 protects against
            hepatic cholesterol overload
  JOURNAL   Cell Rep 42 (4), 112399 (2023)
   PUBMED   37060561
  REMARK    GeneRIF: Complementary gene regulation by NRF1 and NRF2 protects
            against hepatic cholesterol overload.
            Erratum:[Cell Rep. 2023 Jul 25;42(7):112872. PMID: 37454293]
REFERENCE   6  (residues 1 to 534)
  AUTHORS   Carmona MC, Iglesias R, Obregon MJ, Darlington GJ, Villarroya F and
            Giralt M.
  TITLE     Mitochondrial biogenesis and thyroid status maturation in brown fat
            require CCAAT/enhancer-binding protein alpha
  JOURNAL   J Biol Chem 277 (24), 21489-21498 (2002)
   PUBMED   11940593
REFERENCE   7  (residues 1 to 534)
  AUTHORS   Huo L and Scarpulla RC.
  TITLE     Mitochondrial DNA instability and peri-implantation lethality
            associated with targeted disruption of nuclear respiratory factor 1
            in mice
  JOURNAL   Mol Cell Biol 21 (2), 644-654 (2001)
   PUBMED   11134350
REFERENCE   8  (residues 1 to 534)
  AUTHORS   Schaefer L, Engman H and Miller JB.
  TITLE     Coding sequence, chromosomal localization, and expression pattern
            of Nrf1: the mouse homolog of Drosophila erect wing
  JOURNAL   Mamm Genome 11 (2), 104-110 (2000)
   PUBMED   10656923
REFERENCE   9  (residues 1 to 534)
  AUTHORS   Huo L and Scarpulla RC.
  TITLE     Multiple 5'-untranslated exons in the nuclear respiratory factor 1
            gene span 47 kb and contribute to transcript heterogeneity and
            translational efficiency
  JOURNAL   Gene 233 (1-2), 213-224 (1999)
   PUBMED   10375638
REFERENCE   10 (residues 1 to 534)
  AUTHORS   Virbasius CA, Virbasius JV and Scarpulla RC.
  TITLE     NRF-1, an activator involved in nuclear-mitochondrial interactions,
            utilizes a new DNA-binding domain conserved in a family of
            developmental regulators
  JOURNAL   Genes Dev 7 (12A), 2431-2445 (1993)
   PUBMED   8253388
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134897.4 and AC153632.2.
            
            Transcript Variant: This variant (2) contains an alternate exon in
            the 3' coding region which results in a frameshift and early stop
            codon, compared to variant 1. This results in a distinct and longer
            C-terminus in isoform b, compared to isoform a. Variants 2, 7, 13,
            and 14 all encode the same isoform (b).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422600.1832751.1,
                                           SRR13422601.2323916.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..534
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 12.47 cM"
     Protein         1..534
                     /product="nuclear respiratory factor 1 isoform b"
                     /note="NRF-1; alpha-pal; alpha palindromic-binding
                     protein"
                     /calculated_mol_wt=57152
     Region          1..78
                     /region_name="Dimerization. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU00.2)"
     Region          36..57
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU00.2)"
     Site            39
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:Q16656; propagated from
                     UniProtKB/Swiss-Prot (Q9WU00.2)"
     Site            44
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:Q16656; propagated from
                     UniProtKB/Swiss-Prot (Q9WU00.2)"
     Site            46
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:Q16656; propagated from
                     UniProtKB/Swiss-Prot (Q9WU00.2)"
     Site            47
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:Q16656; propagated from
                     UniProtKB/Swiss-Prot (Q9WU00.2)"
     Site            52
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:Q16656; propagated from
                     UniProtKB/Swiss-Prot (Q9WU00.2)"
     Region          87..283
                     /region_name="Nrf1_DNA-bind"
                     /note="NLS-binding and DNA-binding and dimerization
                     domains of Nrf1; pfam10491"
                     /db_xref="CDD:402218"
     Region          88..116
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU00.2)"
     Region          450..525
                     /region_name="TGS_YchF_OLA1"
                     /note="TGS (ThrRS, GTPase and SpoT) domain found in the
                     YchF/OLA1 family proteins; cd04867"
                     /db_xref="CDD:340516"
     CDS             1..534
                     /gene="Nrf1"
                     /gene_synonym="D6Ertd415e"
                     /coded_by="NM_001164227.2:274..1878"
                     /note="isoform b is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS51741.1"
                     /db_xref="GeneID:18181"
                     /db_xref="MGI:MGI:1332235"
ORIGIN      
        1 meehgvtqte hmatieahav aqqvqqvhva tytehsmlsa dedspssped tsyddsdiln
       61 staadevtah laaagpvgma aaaavatgkk rkrphvfesn psirkrqqtr llrklratld
      121 eyttrvgqqa ivlcispskp npvfkvfgaa plenvvrkyk smiledlesa laehapapqe
      181 vnselpplti dgipvsvdkm tqaqlrafip emlkystgrg kpgwgkesck piwwpedipw
      241 anvrsdvrte eqkqrvswtq alrtivkncy kqhgredlly afedqqtqtq attthsiahl
      301 vpsqtvvqtf snpdgtvsli qvgtgatvat ladaselptt vtvaqvnysa vadgeveqnw
      361 atlqggemti qttqaseatq avaslaeaav aasqemqqga tvtmalnsea aahavatlae
      421 atlqgggqiv lsgetaaavg altgvqdang pdgvhawtis kavtapqaag kihtdfgkgf
      481 imaevmkded lkeessenaa kaagkykqqg rayvvedgdi iffkfnspqq lkkk
//
LOCUS       NP_001271158             421 aa            linear   ROD 09-OCT-2023
DEFINITION  nuclear autoantigenic sperm protein isoform 3 [Mus musculus].
ACCESSION   NP_001271158
VERSION     NP_001271158.1
DBSOURCE    REFSEQ: accession NM_001284229.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 421)
  AUTHORS   Bao Y, Lian M, Chen Y, Gu X, Cao K, Du X and Ju J.
  TITLE     sNASP Mutation Aggravates to the TLR4-Mediated Inflammation in SLE
            by TAK1 Pathway
  JOURNAL   J Immunol Res 2023, 4877700 (2023)
   PUBMED   37771504
  REMARK    GeneRIF: sNASP Mutation Aggravates to the TLR4-Mediated
            Inflammation in SLE by TAK1 Pathway.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 421)
  AUTHORS   Li J, Jiang H, Mu Y, Wei Z, Ma A, Sun M, Zhao J, Zhu C and Chen X.
  TITLE     SRSF10 regulates proliferation of neural progenitor cells and
            affects neurogenesis in developing mouse neocortex
  JOURNAL   iScience 26 (7), 107042 (2023)
   PUBMED   37360696
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 421)
  AUTHORS   Zhang Y, Yan H, Zhu J, Chen L, Wang H and Ju J.
  TITLE     [Hepatic fibrosis aggravation in nuclear autoantigenic sperm
            protein (NASP) mutant mice induced by concanavalin A]
  JOURNAL   Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 38 (7), 577-583 (2022)
   PUBMED   35786450
  REMARK    GeneRIF: [Hepatic fibrosis aggravation in nuclear autoantigenic
            sperm protein (NASP) mutant mice induced by concanavalin A].
REFERENCE   4  (residues 1 to 421)
  AUTHORS   Zhang J, Du X, Wang H, Bao Y, Lian M, Xu Z and Ju J.
  TITLE     A Variant of sNASP Exacerbates Lymphocyte Subset Disorder and
            Nephritis in a Spontaneous Lupus Model Sle1.Yaa Mouse
  JOURNAL   Mediators Inflamm 2021, 8175863 (2021)
   PUBMED   34720750
  REMARK    GeneRIF: A Variant of sNASP Exacerbates Lymphocyte Subset Disorder
            and Nephritis in a Spontaneous Lupus Model Sle1.Yaa Mouse.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 421)
  AUTHORS   Ju J, Xu J, Zhu Y, Fu X, Morel L and Xu Z.
  TITLE     A Variant of the Histone-Binding Protein sNASP Contributes to Mouse
            Lupus
  JOURNAL   Front Immunol 10, 637 (2019)
   PUBMED   31001259
  REMARK    GeneRIF: A Variant of the Histone-Binding Protein sNASP Contributes
            to Mouse Lupus.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 421)
  AUTHORS   Piao Y, Ko NT, Lim MK and Ko MS.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   7  (residues 1 to 421)
  AUTHORS   Richardson RT, Bencic DC and O'Rand MG.
  TITLE     Comparison of mouse and human NASP genes and expression in human
            transformed and tumor cell lines
  JOURNAL   Gene 274 (1-2), 67-75 (2001)
   PUBMED   11674998
REFERENCE   8  (residues 1 to 421)
  AUTHORS   Richardson RT, Batova IN, Widgren EE, Zheng LX, Whitfield M,
            Marzluff WF and O'Rand MG.
  TITLE     Characterization of the histone H1-binding protein, NASP, as a cell
            cycle-regulated somatic protein
  JOURNAL   J Biol Chem 275 (39), 30378-30386 (2000)
   PUBMED   10893414
REFERENCE   9  (residues 1 to 421)
  AUTHORS   Hemberger M, Himmelbauer H, Ruschmann J, Zeitz C and Fundele R.
  TITLE     cDNA subtraction cloning reveals novel genes whose temporal and
            spatial expression indicates association with trophoblast invasion
  JOURNAL   Dev Biol 222 (1), 158-169 (2000)
   PUBMED   10885754
REFERENCE   10 (residues 1 to 421)
  AUTHORS   Leimeister C, Bach A, Woolf AS and Gessler M.
  TITLE     Screen for genes regulated during early kidney morphogenesis
  JOURNAL   Dev Genet 24 (3-4), 273-283 (1999)
   PUBMED   10322635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK083333.1, AF095722.1 and AL669953.7.
            
            Transcript Variant: This variant (3) differs in the 5' UTR and
            lacks two alternate in-frame exons in the coding region, compared
            to variant 2. It encodes isoform 3, which is shorter than isoform
            2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF095722.1, SRR7345562.926555.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..421
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 53.24 cM"
     Protein         1..421
                     /product="nuclear autoantigenic sperm protein isoform 3"
                     /note="somatic histone binding protein NASP"
                     /calculated_mol_wt=45623
     Region          145..168
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          174..250
                     /region_name="TPR_12"
                     /note="Tetratricopeptide repeat; pfam13424"
                     /db_xref="CDD:315987"
     Region          176..213
                     /region_name="SHNi-TPR"
                     /note="pfam10516"
                     /db_xref="CDD:402238"
     Region          176..204
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(177,180..181,184..185,187,219,222..223,226..227,
                     229..230,251,254..255,258)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          209..247
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..421
                     /gene="Nasp"
                     /gene_synonym="5033430J04Rik; D4Ertd767e; Epcs32; Nasp-T"
                     /coded_by="NM_001284229.1:108..1373"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS71451.1"
                     /db_xref="GeneID:50927"
                     /db_xref="MGI:MGI:1355328"
ORIGIN      
        1 matestaaaa iaaelvsadk iedapapsts adkmesldvd seakkllglg qkhlvmgdip
       61 aavnafqeaa sllmengvlg nalegvhvee eegektedes lvenndnvde tegseeedre
      121 ndkaeetpne svlekkslqe neeeeignle lawdmldlak iifkrqetke aqlyaaqahl
      181 klgevsvese nyiqaveefq aclslqeqyl eahdrllaet hyqlglaygy nsqydeavaq
      241 fgksidviek rmavlheqmk eaegsfteye keieelkell peirekieda kesqrsgnva
      301 elalkatlve sstsgftpsg agasvsmias rkptdgasss ncvtdishlv rkkrkpeees
      361 prkddakkak qepevnggsg davssgkevs enmeaeaenq aesqtaegtv esaatiksta
      421 c
//
LOCUS       NP_001297612             426 aa            linear   ROD 09-OCT-2023
DEFINITION  mitogen-activated protein kinase 10 isoform 3 [Mus musculus].
ACCESSION   NP_001297612 XP_006535012
VERSION     NP_001297612.1
DBSOURCE    REFSEQ: accession NM_001310683.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 426)
  AUTHORS   Priego M, Noriega L, Kalinin S, Hoffman LM, Feinstein DL and
            Morfini G.
  TITLE     Genetic deletion of c-Jun amino-terminal kinase 3 (JNK3) modestly
            increases disease severity in a mouse model of multiple sclerosis
  JOURNAL   J Neuroimmunol 382, 578152 (2023)
   PUBMED   37454525
  REMARK    GeneRIF: Genetic deletion of c-Jun amino-terminal kinase 3 (JNK3)
            modestly increases disease severity in a mouse model of multiple
            sclerosis.
REFERENCE   2  (residues 1 to 426)
  AUTHORS   Liu F, Deng Y, Zhao Y, Li Z, Gao J, Zhang Y, Yang X, Liu Y and Xia
            Y.
  TITLE     Time series RNA-seq analysis identifies MAPK10 as a critical gene
            in diabetes mellitus-induced atrial fibrillation in mice
  JOURNAL   J Mol Cell Cardiol 168, 70-82 (2022)
   PUBMED   35489387
  REMARK    GeneRIF: Time series RNA-seq analysis identifies MAPK10 as a
            critical gene in diabetes mellitus-induced atrial fibrillation in
            mice.
REFERENCE   3  (residues 1 to 426)
  AUTHORS   Cunningham JG, Scripter JD, Nti SA and Tucker ES.
  TITLE     Early construction of the thalamocortical axon pathway requires
            c-Jun N-terminal kinase signaling within the ventral forebrain
  JOURNAL   Dev Dyn 251 (3), 459-480 (2022)
   PUBMED   34494344
REFERENCE   4  (residues 1 to 426)
  AUTHORS   Goodwani S, Fernandez C, Acton PJ, Buggia-Prevot V, McReynolds ML,
            Ma J, Hu CH, Hamby ME, Jiang Y, Le K, Soth MJ, Jones P and Ray WJ.
  TITLE     Dual Leucine Zipper Kinase Is Constitutively Active in the Adult
            Mouse Brain and Has Both Stress-Induced and Homeostatic Functions
  JOURNAL   Int J Mol Sci 21 (14), 4849 (2020)
   PUBMED   32659913
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 426)
  AUTHORS   Loughran G, Chou MY, Ivanov IP, Jungreis I, Kellis M, Kiran AM,
            Baranov PV and Atkins JF.
  TITLE     Evidence of efficient stop codon readthrough in four mammalian
            genes
  JOURNAL   Nucleic Acids Res 42 (14), 8928-8938 (2014)
   PUBMED   25013167
REFERENCE   6  (residues 1 to 426)
  AUTHORS   Beier H and Grimm M.
  TITLE     Misreading of termination codons in eukaryotes by natural nonsense
            suppressor tRNAs
  JOURNAL   Nucleic Acids Res 29 (23), 4767-4782 (2001)
   PUBMED   11726686
  REMARK    Review article
REFERENCE   7  (residues 1 to 426)
  AUTHORS   Yang DD, Kuan CY, Whitmarsh AJ, Rincon M, Zheng TS, Davis RJ, Rakic
            P and Flavell RA.
  TITLE     Absence of excitotoxicity-induced apoptosis in the hippocampus of
            mice lacking the Jnk3 gene
  JOURNAL   Nature 389 (6653), 865-870 (1997)
   PUBMED   9349820
REFERENCE   8  (residues 1 to 426)
  AUTHORS   Casanova E, Garate C, Ovalle S, Calvo P and Chinchetru MA.
  TITLE     Identification of four splice variants of the mouse
            stress-activated protein kinase JNK/SAPK alpha-isoform
  JOURNAL   Neuroreport 7 (7), 1320-1324 (1996)
   PUBMED   8817558
REFERENCE   9  (residues 1 to 426)
  AUTHORS   Martin JH, Mohit AA and Miller CA.
  TITLE     Developmental expression in the mouse nervous system of the p493F12
            SAP kinase
  JOURNAL   Brain Res Mol Brain Res 35 (1-2), 47-57 (1996)
   PUBMED   8717339
REFERENCE   10 (residues 1 to 426)
  AUTHORS   Suzuki J, Yoshida S, Chen ZL, Momota Y, Kato K, Hirata A and
            Shiosaka S.
  TITLE     Ontogeny of neuropsin mRNA expression in the mouse brain
  JOURNAL   Neurosci Res 23 (4), 345-351 (1995)
   PUBMED   8602273
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC160244.11, AC123664.15,
            AC137121.9 and AC125252.7.
            
            On Jul 17, 2015 this sequence version replaced XP_006535012.1.
            
            Summary: The protein encoded by this gene is a member of the MAP
            kinase family. MAP kinases act as integration points for multiple
            biochemical signals, and thus are involved in a wide variety of
            cellular processes, such as proliferation, differentiation,
            transcription regulation and development. This kinase is
            specifically expressed in a subset of neurons in the nervous system
            and is activated by threonine and tyrosine phosphorylation.
            Targeted deletion of this gene in mice suggests that it may have a
            role in stress-induced neuronal apoptosis. Alternatively spliced
            transcript variants encoding different isoforms have been found for
            this gene. A recent study provided evidence for translational
            readthrough in this gene, and expression of an additional
            C-terminally extended isoform via the use of an alternative
            in-frame translation termination codon. [provided by RefSeq, Dec
            2017].
            
            Transcript Variant: This variant (3) uses an alternate acceptor
            splice site in the 5' region, which results in translation
            initiation from an in-frame, downstream start codon compared to
            variant 1. The encoded isoform (3) has a shorter N-terminus
            compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036275.1, SRR1660821.57275.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..426
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 49.61 cM"
     Protein         1..426
                     /product="mitogen-activated protein kinase 10 isoform 3"
                     /EC_number="2.7.11.24"
                     /note="JNK3 beta1 protein kinase; JNK3 beta2 protein
                     kinase; MAP kinase 10; MAP kinase p49 3F12; c-Jun
                     N-terminal kinase 3; stress-activated protein kinase JNK3;
                     SAPK/Erk/kinase 2"
                     /calculated_mol_wt=47997
     Region          25..360
                     /region_name="STKc_JNK"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     c-Jun N-terminal Kinase; cd07850"
                     /db_xref="CDD:270840"
     Site            order(32..38,40,53,55,72,86,108..114,116..117,151,153,
                     155..156,158,168..169,172,183,185..188,190,227)
                     /site_type="active"
                     /db_xref="CDD:270840"
     Site            order(32..38,40,53,55,86,108..114,158,168)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270840"
     Site            order(72,116,151,153,172,183,185..188,190,227)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270840"
     Site            order(112,118,127,130,159..163,323..324,326,329)
                     /site_type="other"
                     /note="KIM docking site [polypeptide binding]"
                     /db_xref="CDD:270840"
     Site            order(168..178,182..190)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270840"
     CDS             1..426
                     /gene="Mapk10"
                     /gene_synonym="C230008H04Rik; JNK3; JNK3B1; JNK3B2;
                     p493F12; p54bSAPK; SAPK(beta); Serk2"
                     /coded_by="NM_001310683.2:658..1938"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="GeneID:26414"
                     /db_xref="MGI:MGI:1346863"
ORIGIN      
        1 mskskvdnqf ysvevgdstf tvlkryqnlk pigsgaqgiv caaydavldr nvaikklsrp
       61 fqnqthakra yrelvlmkcv nhkniislln vftpqktlee fqdvylvmel mdanlcqviq
      121 meldhermsy llyqmlcgik hlhsagiihr dlkpsnivvk sdctlkildf glartagtsf
      181 mmtpyvvtry yrapevilgm gykenvdiws vgcimgemvr hkilfpgrdy idqwnkvieq
      241 lgtpcpefmk klqptvrnyv enrpkyaglt fpklfpdslf padsehnklk asqardllsk
      301 mlvidpakri svddalqhpy invwydpaev eapppqiydk qlderehtie ewkeliykev
      361 mnseektkng vvkgqpspsg aavnsseslp psssvndiss mstdqtlasd tdssleasag
      421 plgccr
//
LOCUS       NP_032416                329 aa            linear   ROD 09-OCT-2023
DEFINITION  interferon regulatory factor 1 isoform a [Mus musculus].
ACCESSION   NP_032416
VERSION     NP_032416.1
DBSOURCE    REFSEQ: accession NM_008390.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 329)
  AUTHORS   Kong P, Yang M, Wang Y, Yu KN, Wu L and Han W.
  TITLE     Ferroptosis triggered by STAT1- IRF1-ACSL4 pathway was involved in
            radiation-induced intestinal injury
  JOURNAL   Redox Biol 66, 102857 (2023)
   PUBMED   37611494
  REMARK    GeneRIF: Ferroptosis triggered by STAT1- IRF1-ACSL4 pathway was
            involved in radiation-induced intestinal injury.
REFERENCE   2  (residues 1 to 329)
  AUTHORS   Sharma BR, Karki R, Rajesh Y and Kanneganti TD.
  TITLE     Immune regulator IRF1 contributes to ZBP1-, AIM2-, RIPK1-, and
            NLRP12-PANoptosome activation and inflammatory cell death
            (PANoptosis)
  JOURNAL   J Biol Chem 299 (9), 105141 (2023)
   PUBMED   37557956
  REMARK    GeneRIF: Immune regulator IRF1 contributes to ZBP1-, AIM2-, RIPK1-,
            and NLRP12-PANoptosome activation and inflammatory cell death
            (PANoptosis).
REFERENCE   3  (residues 1 to 329)
  AUTHORS   Gungabeesoon J, Gort-Freitas NA, Kiss M, Bolli E, Messemaker M,
            Siwicki M, Hicham M, Bill R, Koch P, Cianciaruso C, Duval F,
            Pfirschke C, Mazzola M, Peters S, Homicsko K, Garris C, Weissleder
            R, Klein AM and Pittet MJ.
  TITLE     A neutrophil response linked to tumor control in immunotherapy
  JOURNAL   Cell 186 (7), 1448-1464 (2023)
   PUBMED   37001504
REFERENCE   4  (residues 1 to 329)
  AUTHORS   Chen X, Qi D, Fan S, He Y, Jing H and Wang D.
  TITLE     Interferon regulatory factor 1 (IRF1) inhibits lung endothelial
            regeneration following inflammation-induced acute lung injury
  JOURNAL   Clin Sci (Lond) 137 (5), 367-383 (2023)
   PUBMED   36857175
  REMARK    GeneRIF: Interferon regulatory factor 1 (IRF1) inhibits lung
            endothelial regeneration following inflammation-induced acute lung
            injury.
REFERENCE   5  (residues 1 to 329)
  AUTHORS   Rosain J, Neehus AL, Manry J, Yang R, Le Pen J, Daher W, Liu Z,
            Chan YH, Tahuil N, Turel O, Bourgey M, Ogishi M, Doisne JM,
            Izquierdo HM, Shirasaki T, Le Voyer T, Guerin A, Bastard P,
            Moncada-Velez M, Han JE, Khan T, Rapaport F, Hong SH, Cheung A,
            Haake K, Mindt BC, Perez L, Philippot Q, Lee D, Zhang P, Rinchai D,
            Al Ali F, Ahmad Ata MM, Rahman M, Peel JN, Heissel S, Molina H,
            Kendir-Demirkol Y, Bailey R, Zhao S, Bohlen J, Mancini M,
            Seeleuthner Y, Roelens M, Lorenzo L, Soudee C, Paz MEJ, Gonzalez
            ML, Jeljeli M, Soulier J, Romana S, L'Honneur AS, Materna M,
            Martinez-Barricarte R, Pochon M, Oleaga-Quintas C, Michev A, Migaud
            M, Levy R, Alyanakian MA, Rozenberg F, Croft CA, Vogt G, Emile JF,
            Kremer L, Ma CS, Fritz JH, Lemon SM, Spaan AN, Manel N, Abel L,
            MacDonald MR, Boisson-Dupuis S, Marr N, Tangye SG, Di Santo JP,
            Zhang Q, Zhang SY, Rice CM, Beziat V, Lachmann N, Langlais D,
            Casanova JL, Gros P and Bustamante J.
  TITLE     Human IRF1 governs macrophagic IFN-gamma immunity to mycobacteria
  JOURNAL   Cell 186 (3), 621-645 (2023)
   PUBMED   36736301
REFERENCE   6  (residues 1 to 329)
  AUTHORS   Gribaudo G, Caliendo A, Lembo D, Cavallo R and Landolfo S.
  TITLE     Molecular cloning of interferon-gamma inducible genes from a murine
            pre-B cell leukemia
  JOURNAL   J Biol Regul Homeost Agents 6 (4), 137-141 (1992)
   PUBMED   1296455
REFERENCE   7  (residues 1 to 329)
  AUTHORS   Tanaka N and Taniguchi T.
  TITLE     Cytokine gene regulation: regulatory cis-elements and DNA binding
            factors involved in the interferon system
  JOURNAL   Adv Immunol 52, 263-281 (1992)
   PUBMED   1442307
  REMARK    Review article
REFERENCE   8  (residues 1 to 329)
  AUTHORS   Buckwalter MS, Lossie AC, Scarlett LM and Camper SA.
  TITLE     Localization of the human chromosome 5q genes Gabra-1, Gabrg-2,
            Il-4, Il-5, and Irf-1 on mouse chromosome 11
  JOURNAL   Mamm Genome 3 (10), 604-607 (1992)
   PUBMED   1358285
REFERENCE   9  (residues 1 to 329)
  AUTHORS   Driggers PH, Ennist DL, Gleason SL, Mak WH, Marks MS, Levi BZ,
            Flanagan JR, Appella E and Ozato K.
  TITLE     An interferon gamma-regulated protein that binds the
            interferon-inducible enhancer element of major histocompatibility
            complex class I genes
  JOURNAL   Proc Natl Acad Sci U S A 87 (10), 3743-3747 (1990)
   PUBMED   2111015
REFERENCE   10 (residues 1 to 329)
  AUTHORS   Harada H, Fujita T, Miyamoto M, Kimura Y, Maruyama M, Furia A,
            Miyata T and Taniguchi T.
  TITLE     Structurally similar but functionally distinct factors, IRF-1 and
            IRF-2, bind to the same regulatory elements of IFN and
            IFN-inducible genes
  JOURNAL   Cell 58 (4), 729-739 (1989)
   PUBMED   2475256
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY266109.1, AK152005.1 and BE950981.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a). Both variants 1 and
            2 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK152005.1, AK152104.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..329
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 32.0 cM"
     Protein         1..329
                     /product="interferon regulatory factor 1 isoform a"
                     /calculated_mol_wt=37188
     Region          7..112
                     /region_name="IRF"
                     /note="Interferon regulatory factor transcription factor;
                     pfam00605"
                     /db_xref="CDD:425772"
     Site            order(40,80,82..83,86)
                     /site_type="other"
                     /note="DNA sequence recognition sites [nucleotide
                     binding]"
                     /db_xref="CDD:238051"
     Site            78
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P10914; propagated from
                     UniProtKB/Swiss-Prot (P15314.1)"
     Site            order(85..86,88,91)
                     /site_type="metal-binding"
                     /db_xref="CDD:238051"
     Region          93..166
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P15314.1)"
     CDS             1..329
                     /gene="Irf1"
                     /gene_synonym="Irf-1"
                     /coded_by="NM_008390.2:270..1259"
                     /note="isoform a is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS24686.1"
                     /db_xref="GeneID:16362"
                     /db_xref="MGI:MGI:96590"
ORIGIN      
        1 mpitrmrmrp wlemqinsnq ipgliwinke emifqipwkh aakhgwdink daclfrswai
       61 htgrykagek epdpktwkan frcamnslpd ieevkdqsrn kgssavrvyr mlppltrnqr
      121 kerkskssrd tksktkrklc gdvspdtfsd glssstlpdd hssyttqgyl gqdldmerdi
      181 tpalspcvvs sslsewhmqm diipdsttdl ynlqvspmps tseaatdede egkiaedlmk
      241 lfeqsewqpt hidgkgylln epgtqlssvy gdfsckeepe idsprgdigi giqhvftemk
      301 nmdsimwmds llgnsvrlpp siqaipcap
//
LOCUS       NP_001348621             534 aa            linear   ROD 09-OCT-2023
DEFINITION  nuclear respiratory factor 1 isoform b [Mus musculus].
ACCESSION   NP_001348621 XP_017176931
VERSION     NP_001348621.1
DBSOURCE    REFSEQ: accession NM_001361692.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 534)
  AUTHORS   Cheng C, Tian Y, Yang R, Guo W, Xiao K, Zhang F, Tian J, Deng Z,
            Yang W, Yang H and Zhou Z.
  TITLE     miR-5581 Contributes to Osteoarthritis by Targeting NRF1 to Disturb
            the Proliferation and Functions of Chondrocytes
  JOURNAL   Am J Pathol 193 (9), 1234-1247 (2023)
   PUBMED   37611970
  REMARK    GeneRIF: miR-5581 Contributes to Osteoarthritis by Targeting NRF1
            to Disturb the Proliferation and Functions of Chondrocytes.
REFERENCE   2  (residues 1 to 534)
  AUTHORS   Meng Z, Liang B, Wu Y, Liu C, Wang H, Du Y, Gan L, Gao E, Lau WB,
            Christopher TA, Lopez BL, Koch WJ, Ma X, Zhao F, Wang Y and Zhao J.
  TITLE     Hypoadiponectinemia-induced upregulation of microRNA449b
            downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury
            in diabetic mice
  JOURNAL   J Mol Cell Cardiol 182, 1-14 (2023)
   PUBMED   37437402
  REMARK    GeneRIF: Hypoadiponectinemia-induced upregulation of microRNA449b
            downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury
            in diabetic mice.
REFERENCE   3  (residues 1 to 534)
  AUTHORS   Zhao T, Zhang J, Lei H, Meng Y, Cheng H, Zhao Y, Geng G, Mu C, Chen
            L, Liu Q, Luo Q, Zhang C, Long Y, Su J, Wang Y, Li Z, Sun J, Chen
            G, Li Y, Liao X, Shang Y, Hu G, Chen Q and Zhu Y.
  TITLE     NRF1-mediated mitochondrial biogenesis antagonizes innate antiviral
            immunity
  JOURNAL   EMBO J 42 (16), e113258 (2023)
   PUBMED   37409632
  REMARK    GeneRIF: NRF1-mediated mitochondrial biogenesis antagonizes innate
            antiviral immunity.
REFERENCE   4  (residues 1 to 534)
  AUTHORS   Akl MG, Baccetto R, Stebbings BM, Li L and Widenmaier SB.
  TITLE     Euglycemia is affected by stress defense factor hepatocyte NRF1,
            but not NRF2
  JOURNAL   Biochem Biophys Res Commun 668, 96-103 (2023)
   PUBMED   37245295
  REMARK    GeneRIF: Euglycemia is affected by stress defense factor hepatocyte
            NRF1, but not NRF2.
REFERENCE   5  (residues 1 to 534)
  AUTHORS   Akl MG, Li L, Baccetto R, Phanse S, Zhang Q, Trites MJ, McDonald S,
            Aoki H, Babu M and Widenmaier SB.
  TITLE     Complementary gene regulation by NRF1 and NRF2 protects against
            hepatic cholesterol overload
  JOURNAL   Cell Rep 42 (4), 112399 (2023)
   PUBMED   37060561
  REMARK    GeneRIF: Complementary gene regulation by NRF1 and NRF2 protects
            against hepatic cholesterol overload.
            Erratum:[Cell Rep. 2023 Jul 25;42(7):112872. PMID: 37454293]
REFERENCE   6  (residues 1 to 534)
  AUTHORS   Carmona MC, Iglesias R, Obregon MJ, Darlington GJ, Villarroya F and
            Giralt M.
  TITLE     Mitochondrial biogenesis and thyroid status maturation in brown fat
            require CCAAT/enhancer-binding protein alpha
  JOURNAL   J Biol Chem 277 (24), 21489-21498 (2002)
   PUBMED   11940593
REFERENCE   7  (residues 1 to 534)
  AUTHORS   Huo L and Scarpulla RC.
  TITLE     Mitochondrial DNA instability and peri-implantation lethality
            associated with targeted disruption of nuclear respiratory factor 1
            in mice
  JOURNAL   Mol Cell Biol 21 (2), 644-654 (2001)
   PUBMED   11134350
REFERENCE   8  (residues 1 to 534)
  AUTHORS   Schaefer L, Engman H and Miller JB.
  TITLE     Coding sequence, chromosomal localization, and expression pattern
            of Nrf1: the mouse homolog of Drosophila erect wing
  JOURNAL   Mamm Genome 11 (2), 104-110 (2000)
   PUBMED   10656923
REFERENCE   9  (residues 1 to 534)
  AUTHORS   Huo L and Scarpulla RC.
  TITLE     Multiple 5'-untranslated exons in the nuclear respiratory factor 1
            gene span 47 kb and contribute to transcript heterogeneity and
            translational efficiency
  JOURNAL   Gene 233 (1-2), 213-224 (1999)
   PUBMED   10375638
REFERENCE   10 (residues 1 to 534)
  AUTHORS   Virbasius CA, Virbasius JV and Scarpulla RC.
  TITLE     NRF-1, an activator involved in nuclear-mitochondrial interactions,
            utilizes a new DNA-binding domain conserved in a family of
            developmental regulators
  JOURNAL   Genes Dev 7 (12A), 2431-2445 (1993)
   PUBMED   8253388
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153632.2.
            
            On Mar 29, 2018 this sequence version replaced XP_017176931.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.106717.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849390
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..534
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 12.47 cM"
     Protein         1..534
                     /product="nuclear respiratory factor 1 isoform b"
                     /note="NRF-1; alpha-pal; alpha palindromic-binding
                     protein"
                     /calculated_mol_wt=57152
     Region          1..78
                     /region_name="Dimerization. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU00.2)"
     Region          36..57
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU00.2)"
     Site            39
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:Q16656; propagated from
                     UniProtKB/Swiss-Prot (Q9WU00.2)"
     Site            44
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:Q16656; propagated from
                     UniProtKB/Swiss-Prot (Q9WU00.2)"
     Site            46
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:Q16656; propagated from
                     UniProtKB/Swiss-Prot (Q9WU00.2)"
     Site            47
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:Q16656; propagated from
                     UniProtKB/Swiss-Prot (Q9WU00.2)"
     Site            52
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:Q16656; propagated from
                     UniProtKB/Swiss-Prot (Q9WU00.2)"
     Region          87..283
                     /region_name="Nrf1_DNA-bind"
                     /note="NLS-binding and DNA-binding and dimerization
                     domains of Nrf1; pfam10491"
                     /db_xref="CDD:402218"
     Region          88..116
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU00.2)"
     Region          450..525
                     /region_name="TGS_YchF_OLA1"
                     /note="TGS (ThrRS, GTPase and SpoT) domain found in the
                     YchF/OLA1 family proteins; cd04867"
                     /db_xref="CDD:340516"
     CDS             1..534
                     /gene="Nrf1"
                     /gene_synonym="D6Ertd415e"
                     /coded_by="NM_001361692.2:1815..3419"
                     /note="isoform b is encoded by transcript variant 7"
                     /db_xref="CCDS:CCDS51741.1"
                     /db_xref="GeneID:18181"
                     /db_xref="MGI:MGI:1332235"
ORIGIN      
        1 meehgvtqte hmatieahav aqqvqqvhva tytehsmlsa dedspssped tsyddsdiln
       61 staadevtah laaagpvgma aaaavatgkk rkrphvfesn psirkrqqtr llrklratld
      121 eyttrvgqqa ivlcispskp npvfkvfgaa plenvvrkyk smiledlesa laehapapqe
      181 vnselpplti dgipvsvdkm tqaqlrafip emlkystgrg kpgwgkesck piwwpedipw
      241 anvrsdvrte eqkqrvswtq alrtivkncy kqhgredlly afedqqtqtq attthsiahl
      301 vpsqtvvqtf snpdgtvsli qvgtgatvat ladaselptt vtvaqvnysa vadgeveqnw
      361 atlqggemti qttqaseatq avaslaeaav aasqemqqga tvtmalnsea aahavatlae
      421 atlqgggqiv lsgetaaavg altgvqdang pdgvhawtis kavtapqaag kihtdfgkgf
      481 imaevmkded lkeessenaa kaagkykqqg rayvvedgdi iffkfnspqq lkkk
//
LOCUS       NP_001392988             143 aa            linear   ROD 09-OCT-2023
DEFINITION  bcl-2-like protein 11 isoform 6 [Mus musculus].
ACCESSION   NP_001392988
VERSION     NP_001392988.1
DBSOURCE    REFSEQ: accession NM_001406059.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 143)
  AUTHORS   Jiang M, Wang XB and Jiang S.
  TITLE     circ_0000018 downregulation peripherally ameliorates
            neuroprotection against acute ischemic stroke through the
            miR-871/BCL2L11 axis
  JOURNAL   Mol Med Rep 28 (5) (2023)
   PUBMED   37772397
  REMARK    GeneRIF: circ_0000018 downregulation peripherally ameliorates
            neuroprotection against acute ischemic stroke through the
            miR-871/BCL2L11 axis.
REFERENCE   2  (residues 1 to 143)
  AUTHORS   Lu Y, Tang K, Wang S, Tian Z, Fan Y, Li B, Wang M, Zhao J and Xie
            J.
  TITLE     Dach1 deficiency drives alveolar epithelium apoptosis in pulmonary
            fibrosis via modulating C-Jun/Bim activity
  JOURNAL   Transl Res 257, 54-65 (2023)
   PUBMED   36754276
  REMARK    GeneRIF: Dach1 deficiency drives alveolar epithelium apoptosis in
            pulmonary fibrosis via modulating C-Jun/Bim activity.
REFERENCE   3  (residues 1 to 143)
  AUTHORS   Nguyen HV, Vandenberg CJ, Robati MR, Ng AP and Cory S.
  TITLE     MNT suppresses T cell apoptosis via BIM and is critical for T
            lymphomagenesis
  JOURNAL   Cell Death Differ 30 (4), 1018-1032 (2023)
   PUBMED   36755068
  REMARK    GeneRIF: MNT suppresses T cell apoptosis via BIM and is critical
            for T lymphomagenesis.
REFERENCE   4  (residues 1 to 143)
  AUTHORS   Chen H, Bai Y, Kobayashi M, Xiao S, Cai W, Barajas S, Chen S, Miao
            J, Meke FN, Vemula S, Ropa JP, Croop JM, Boswell HS, Wan J, Jia Y,
            Liu H, Li LS, Altman JK, Eklund EA, Ji P, Tong W, Band H, Huang DT,
            Platanias LC, Zhang ZY and Liu Y.
  TITLE     PRL2 phosphatase enhances oncogenic FLT3 signaling via
            dephosphorylation of the E3 ubiquitin ligase CBL at tyrosine 371
  JOURNAL   Blood 141 (3), 244-259 (2023)
   PUBMED   36206490
REFERENCE   5  (residues 1 to 143)
  AUTHORS   Brahma MK, Xiao P, Popa M, Negueruela J, Vandenbempt V, Demine S,
            Cardozo AK and Gurzov EN.
  TITLE     Nova1 or Bim Deficiency in Pancreatic beta-Cells Does Not Alter
            Multiple Low-Dose Streptozotocin-Induced Diabetes and Diet-Induced
            Obesity in Mice
  JOURNAL   Nutrients 14 (18), 3866 (2022)
   PUBMED   36145242
  REMARK    GeneRIF: Nova1 or Bim Deficiency in Pancreatic beta-Cells Does Not
            Alter Multiple Low-Dose Streptozotocin-Induced Diabetes and
            Diet-Induced Obesity in Mice.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 143)
  AUTHORS   Bouillet P, Zhang LC, Huang DC, Webb GC, Bottema CD, Shore P, Eyre
            HJ, Sutherland GR and Adams JM.
  TITLE     Gene structure alternative splicing, and chromosomal localization
            of pro-apoptotic Bcl-2 relative Bim
  JOURNAL   Mamm Genome 12 (2), 163-168 (2001)
   PUBMED   11210187
REFERENCE   7  (residues 1 to 143)
  AUTHORS   Bouillet P, Metcalf D, Huang DC, Tarlinton DM, Kay TW, Kontgen F,
            Adams JM and Strasser A.
  TITLE     Proapoptotic Bcl-2 relative Bim required for certain apoptotic
            responses, leukocyte homeostasis, and to preclude autoimmunity
  JOURNAL   Science 286 (5445), 1735-1738 (1999)
   PUBMED   10576740
REFERENCE   8  (residues 1 to 143)
  AUTHORS   Puthalakath H, Huang DC, O'Reilly LA, King SM and Strasser A.
  TITLE     The proapoptotic activity of the Bcl-2 family member Bim is
            regulated by interaction with the dynein motor complex
  JOURNAL   Mol Cell 3 (3), 287-296 (1999)
   PUBMED   10198631
REFERENCE   9  (residues 1 to 143)
  AUTHORS   Reed JC.
  TITLE     Bcl-2 family proteins
  JOURNAL   Oncogene 17 (25), 3225-3236 (1998)
   PUBMED   9916985
  REMARK    Review article
REFERENCE   10 (residues 1 to 143)
  AUTHORS   O'Connor L, Strasser A, O'Reilly LA, Hausmann G, Adams JM, Cory S
            and Huang DC.
  TITLE     Bim: a novel member of the Bcl-2 family that promotes apoptosis
  JOURNAL   EMBO J 17 (2), 384-395 (1998)
   PUBMED   9430630
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL805950.11.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13861889.154247.1,
                                           SRR17784651.90518.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..143
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 62.23 cM"
     Protein         1..143
                     /product="bcl-2-like protein 11 isoform 6"
                     /note="bcl-2-like protein 11; bcl2-interacting mediator of
                     cell death; Bcl2 interacting mediator of cell death;
                     BCL2-like 11 (apoptosis facilitator)"
                     /calculated_mol_wt=15972
     Region          4..40
                     /region_name="Bim_N"
                     /note="Bim protein N-terminus; pfam06773"
                     /db_xref="CDD:429111"
     Region          73..110
                     /region_name="Bclx_interact"
                     /note="Bcl-x interacting, BH3 domain; pfam08945"
                     /db_xref="CDD:430337"
     CDS             1..143
                     /gene="Bcl2l11"
                     /gene_synonym="1500006F24Rik; bcl2-L-11; Bim; Bod"
                     /coded_by="NM_001406059.1:229..660"
                     /note="isoform 6 is encoded by transcript variant 8"
                     /db_xref="GeneID:12125"
                     /db_xref="MGI:MGI:1197519"
ORIGIN      
        1 makqpsdvss ecdreggqlq paerppqlrp gaptslqtep qdrspapmsc dkstqtpspp
       61 cqafnhylsa masirqsqee pedlrpeiri aqelrrigde fnetytrrvr tsphpqrkcn
      121 cgdmapfctl rylspnsalt wci
//
LOCUS       NP_001349230             501 aa            linear   ROD 09-OCT-2023
DEFINITION  CUGBP Elav-like family member 4 isoform 25 [Mus musculus].
ACCESSION   NP_001349230
VERSION     NP_001349230.1
DBSOURCE    REFSEQ: accession NM_001362301.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 501)
  AUTHORS   Salamon I, Park Y, Miskic T, Kopic J, Matteson P, Page NF, Roque A,
            McAuliffe GW, Favate J, Garcia-Forn M, Shah P, Judas M, Millonig
            JH, Kostovic I, De Rubeis S, Hart RP, Krsnik Z and Rasin MR.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    GeneRIF: Celf4 controls mRNA translation underlying synaptic
            development in the prenatal mammalian neocortex.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 501)
  AUTHORS   Shen Y, Zhang C, Xiao K, Liu D and Xie G.
  TITLE     CELF4 regulates spine formation and depression-like behaviors of
            mice
  JOURNAL   Biochem Biophys Res Commun 605, 39-44 (2022)
   PUBMED   35306363
  REMARK    GeneRIF: CELF4 regulates spine formation and depression-like
            behaviors of mice.
REFERENCE   3  (residues 1 to 501)
  AUTHORS   Moreau MX, Saillour Y, Cwetsch AW, Pierani A and Causeret F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   4  (residues 1 to 501)
  AUTHORS   Li C, Li X, Bi Z, Sugino K, Wang G, Zhu T and Liu Z.
  TITLE     Comprehensive transcriptome analysis of cochlear spiral ganglion
            neurons at multiple ages
  JOURNAL   Elife 9, e50491 (2020)
   PUBMED   31913118
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 501)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 501)
  AUTHORS   Ladd AN, Taffet G, Hartley C, Kearney DL and Cooper TA.
  TITLE     Cardiac tissue-specific repression of CELF activity disrupts
            alternative splicing and causes cardiomyopathy
  JOURNAL   Mol Cell Biol 25 (14), 6267-6278 (2005)
   PUBMED   15988035
  REMARK    GeneRIF: CELF protein activity is required for normal alternative
            splicing in the heart in vivo and normal CELF-mediated alternative
            splicing regulation is in turn required for normal cardiac
            function.
REFERENCE   7  (residues 1 to 501)
  AUTHORS   Meins M, Schlickum S, Wilhelm C, Missbach J, Yadav S, Glaser B,
            Grzmil M, Burfeind P and Laccone F.
  TITLE     Identification and characterization of murine Brunol4, a new member
            of the elav/bruno family
  JOURNAL   Cytogenet Genome Res 97 (3-4), 254-260 (2002)
   PUBMED   12438720
  REMARK    GeneRIF: cloning and characterization
REFERENCE   8  (residues 1 to 501)
  AUTHORS   Ladd AN, Charlet N and Cooper TA.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   9  (residues 1 to 501)
  AUTHORS   Good PJ, Chen Q, Warner SJ and Herring DC.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
REFERENCE   10 (residues 1 to 501)
  AUTHORS   Yulug IG, Egan SE, See CG and Fisher EM.
  TITLE     Mapping GRB2, a signal transduction gene in the human and the mouse
  JOURNAL   Genomics 22 (2), 313-318 (1994)
   PUBMED   7806216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121094.8 and AC144938.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.23663.1,
                                           SRR1660821.118042.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 13.92 cM"
     Protein         1..501
                     /product="CUGBP Elav-like family member 4 isoform 25"
                     /note="CUG-BP- and ETR-3-like factor 4; bruno-like protein
                     4; RNA-binding protein BRUNOL-4; bruno-like 4, RNA binding
                     protein"
                     /calculated_mol_wt=53477
     Region          49..135
                     /region_name="RRM1_CELF3_4_5_6"
                     /note="RNA recognition motif 1 (RRM1) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12632"
                     /db_xref="CDD:410041"
     Site            order(55,57,59..60,63,82,84,86,95..97,99,129,131)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410041"
     Region          <56..378
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     Region          151..231
                     /region_name="RRM2_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12635"
                     /db_xref="CDD:410043"
     Site            order(153,155,157..158,161,180,182,184,192..194,196,226,
                     228)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410043"
     Region          416..490
                     /region_name="RRM_SF"
                     /note="RNA recognition motif (RRM) superfamily; cl17169"
                     /db_xref="CDD:450164"
     CDS             1..501
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /coded_by="NM_001362301.1:531..2036"
                     /note="isoform 25 is encoded by transcript variant 30"
                     /db_xref="GeneID:108013"
                     /db_xref="MGI:MGI:1932407"
ORIGIN      
        1 myikmatlan gqadnaslst nglgsspgsa ghmnglshsp gnpstipmkd hdaiklfigq
       61 iprnldekdl kplfeefgki yeltvlkdrf tgmhkgcafl tyceresalk aqsalheqkt
      121 lpgmnrpiqv kpadsesrgg ssclrqppsq drklfvgmln kqqseddvrr lfeafgniee
      181 ctilrgpdgn skgcafvkys shaeaqaain alhgsqtmpg assslvvkfa dtdkertmrr
      241 mqqmagqmgm fnpmaipfga ygayaqalmq qqaalmasva qggylnpmaa faaaqmqqma
      301 alnmnglaaa pmtptsggst ppgitapavp sipspigvng ftglppqang qpaaeavfan
      361 gihpypaqsp taadplqqay agvqqyagpa ypaaygqisq afpqpppmip qqqregpegc
      421 nlliyhlpqe fgdaelmqmf lpfgnvissk vfvdratnqs fvsfdnpasa qtaiqamngf
      481 qigmkrlkvq lkrpkdanrp y
//
LOCUS       NP_001349205             544 aa            linear   ROD 09-OCT-2023
DEFINITION  CUGBP Elav-like family member 4 isoform 2 [Mus musculus].
ACCESSION   NP_001349205 XP_017173272
VERSION     NP_001349205.1
DBSOURCE    REFSEQ: accession NM_001362276.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 544)
  AUTHORS   Salamon I, Park Y, Miskic T, Kopic J, Matteson P, Page NF, Roque A,
            McAuliffe GW, Favate J, Garcia-Forn M, Shah P, Judas M, Millonig
            JH, Kostovic I, De Rubeis S, Hart RP, Krsnik Z and Rasin MR.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    GeneRIF: Celf4 controls mRNA translation underlying synaptic
            development in the prenatal mammalian neocortex.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 544)
  AUTHORS   Shen Y, Zhang C, Xiao K, Liu D and Xie G.
  TITLE     CELF4 regulates spine formation and depression-like behaviors of
            mice
  JOURNAL   Biochem Biophys Res Commun 605, 39-44 (2022)
   PUBMED   35306363
  REMARK    GeneRIF: CELF4 regulates spine formation and depression-like
            behaviors of mice.
REFERENCE   3  (residues 1 to 544)
  AUTHORS   Moreau MX, Saillour Y, Cwetsch AW, Pierani A and Causeret F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   4  (residues 1 to 544)
  AUTHORS   Li C, Li X, Bi Z, Sugino K, Wang G, Zhu T and Liu Z.
  TITLE     Comprehensive transcriptome analysis of cochlear spiral ganglion
            neurons at multiple ages
  JOURNAL   Elife 9, e50491 (2020)
   PUBMED   31913118
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 544)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 544)
  AUTHORS   Ladd AN, Taffet G, Hartley C, Kearney DL and Cooper TA.
  TITLE     Cardiac tissue-specific repression of CELF activity disrupts
            alternative splicing and causes cardiomyopathy
  JOURNAL   Mol Cell Biol 25 (14), 6267-6278 (2005)
   PUBMED   15988035
  REMARK    GeneRIF: CELF protein activity is required for normal alternative
            splicing in the heart in vivo and normal CELF-mediated alternative
            splicing regulation is in turn required for normal cardiac
            function.
REFERENCE   7  (residues 1 to 544)
  AUTHORS   Meins M, Schlickum S, Wilhelm C, Missbach J, Yadav S, Glaser B,
            Grzmil M, Burfeind P and Laccone F.
  TITLE     Identification and characterization of murine Brunol4, a new member
            of the elav/bruno family
  JOURNAL   Cytogenet Genome Res 97 (3-4), 254-260 (2002)
   PUBMED   12438720
  REMARK    GeneRIF: cloning and characterization
REFERENCE   8  (residues 1 to 544)
  AUTHORS   Ladd AN, Charlet N and Cooper TA.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   9  (residues 1 to 544)
  AUTHORS   Good PJ, Chen Q, Warner SJ and Herring DC.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
REFERENCE   10 (residues 1 to 544)
  AUTHORS   Yulug IG, Egan SE, See CG and Fisher EM.
  TITLE     Mapping GRB2, a signal transduction gene in the human and the mouse
  JOURNAL   Genomics 22 (2), 313-318 (1994)
   PUBMED   7806216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121094.8 and AC144938.3.
            
            On Apr 12, 2018 this sequence version replaced XP_017173272.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.126746.1,
                                           SRR17784649.166374.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..544
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 13.92 cM"
     Protein         1..544
                     /product="CUGBP Elav-like family member 4 isoform 2"
                     /note="CUG-BP- and ETR-3-like factor 4; bruno-like protein
                     4; RNA-binding protein BRUNOL-4; bruno-like 4, RNA binding
                     protein"
                     /calculated_mol_wt=57868
     Region          1..298
                     /region_name="Sufficient for RNA-binding and MSE-dependent
                     splicing activity. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          18..39
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          49..135
                     /region_name="RRM1_CELF3_4_5_6"
                     /note="RNA recognition motif 1 (RRM1) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12632"
                     /db_xref="CDD:410041"
     Site            order(55,57,59..60,63,82,84,86,95..97,99,129,131)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410041"
     Region          <56..378
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     Region          121..149
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          151..231
                     /region_name="RRM2_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12635"
                     /db_xref="CDD:410043"
     Site            order(153,155,157..158,161,180,182,184,192..194,196,226,
                     228)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410043"
     Region          239..258
                     /region_name="Necessary for TNNT2 exon 5 inclusion.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          416..>444
                     /region_name="RRM_SF"
                     /note="RNA recognition motif (RRM) superfamily; cl17169"
                     /db_xref="CDD:450164"
     CDS             1..544
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /coded_by="NM_001362276.1:531..2165"
                     /note="isoform 2 is encoded by transcript variant 8"
                     /db_xref="GeneID:108013"
                     /db_xref="MGI:MGI:1932407"
ORIGIN      
        1 myikmatlan gqadnaslst nglgsspgsa ghmnglshsp gnpstipmkd hdaiklfigq
       61 iprnldekdl kplfeefgki yeltvlkdrf tgmhkgcafl tyceresalk aqsalheqkt
      121 lpgmnrpiqv kpadsesrgg ssclrqppsq drklfvgmln kqqseddvrr lfeafgniee
      181 ctilrgpdgn skgcafvkys shaeaqaain alhgsqtmpg assslvvkfa dtdkertmrr
      241 mqqmagqmgm fnpmaipfga ygayaqalmq qqaalmasva qggylnpmaa faaaqmqqma
      301 alnmnglaaa pmtptsggst ppgitapavp sipspigvng ftglppqang qpaaeavfan
      361 gihpypaqsp taadplqqay agvqqyagpa ypaaygqisq afpqpppmip qqqregpegc
      421 nlliyhlpqe fgdaelmqmf lpfgrhpvps rcqapscqgg qcaisssarr lrelrqpgqr
      481 tdrhpgherl pdrheeaqga aeaaqrrqsp vlsaggsvpr grpglaqgqs nppqsraelg
      541 ikft
//
LOCUS       NP_001351568             180 aa            linear   ROD 09-OCT-2023
DEFINITION  RNA-binding protein Nova-1 isoform 6 [Mus musculus].
ACCESSION   NP_001351568 XP_006516217
VERSION     NP_001351568.1
DBSOURCE    REFSEQ: accession NM_001364639.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 180)
  AUTHORS   Tajima Y, Ito K, Yuan Y, Frank MO, Saito Y and Darnell RB.
  TITLE     NOVA1 acts on Impact to regulate hypothalamic function and
            translation in inhibitory neurons
  JOURNAL   Cell Rep 42 (2), 112050 (2023)
   PUBMED   36716149
  REMARK    GeneRIF: NOVA1 acts on Impact to regulate hypothalamic function and
            translation in inhibitory neurons.
REFERENCE   2  (residues 1 to 180)
  AUTHORS   Brahma MK, Xiao P, Popa M, Negueruela J, Vandenbempt V, Demine S,
            Cardozo AK and Gurzov EN.
  TITLE     Nova1 or Bim Deficiency in Pancreatic beta-Cells Does Not Alter
            Multiple Low-Dose Streptozotocin-Induced Diabetes and Diet-Induced
            Obesity in Mice
  JOURNAL   Nutrients 14 (18), 3866 (2022)
   PUBMED   36145242
  REMARK    GeneRIF: Nova1 or Bim Deficiency in Pancreatic beta-Cells Does Not
            Alter Multiple Low-Dose Streptozotocin-Induced Diabetes and
            Diet-Induced Obesity in Mice.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 180)
  AUTHORS   Krach F, Wheeler EC, Regensburger M, Boerstler T, Wend H, Vu AQ,
            Wang R, Reischl S, Boldt K, Batra R, Aigner S, Ravits J, Winkler J,
            Yeo GW and Winner B.
  TITLE     Aberrant NOVA1 function disrupts alternative splicing in early
            stages of amyotrophic lateral sclerosis
  JOURNAL   Acta Neuropathol 144 (3), 413-435 (2022)
   PUBMED   35778567
  REMARK    GeneRIF: Aberrant NOVA1 function disrupts alternative splicing in
            early stages of amyotrophic lateral sclerosis.
REFERENCE   4  (residues 1 to 180)
  AUTHORS   Li D, Shen M, Deng X and Bai Y.
  TITLE     MicroRNA miR-27a-3p accelerates cardiac hypertrophy by targeting
            neuro-oncological ventral antigen 1
  JOURNAL   Bioengineered 13 (4), 8982-8993 (2022)
   PUBMED   35348441
  REMARK    GeneRIF: MicroRNA miR-27a-3p accelerates cardiac hypertrophy by
            targeting neuro-oncological ventral antigen 1.
REFERENCE   5  (residues 1 to 180)
  AUTHORS   Johnson V, Junge HJ and Chen Z.
  TITLE     Temporal regulation of axonal repulsion by alternative splicing of
            a conserved microexon in mammalian Robo1 and Robo2
  JOURNAL   Elife 8, e46042 (2019)
   PUBMED   31392959
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 180)
  AUTHORS   Jensen KB, Dredge BK, Stefani G, Zhong R, Buckanovich RJ, Okano HJ,
            Yang YY and Darnell RB.
  TITLE     Nova-1 regulates neuron-specific alternative splicing and is
            essential for neuronal viability
  JOURNAL   Neuron 25 (2), 359-371 (2000)
   PUBMED   10719891
REFERENCE   7  (residues 1 to 180)
  AUTHORS   Yang YY, Yin GL and Darnell RB.
  TITLE     The neuronal RNA-binding protein Nova-2 is implicated as the
            autoantigen targeted in POMA patients with dementia
  JOURNAL   Proc Natl Acad Sci U S A 95 (22), 13254-13259 (1998)
   PUBMED   9789075
REFERENCE   8  (residues 1 to 180)
  AUTHORS   Fletcher CF, Okano HJ, Gilbert DJ, Yang Y, Yang C, Copeland NG,
            Jenkins NA and Darnell RB.
  TITLE     Mouse chromosomal locations of nine genes encoding homologs of
            human paraneoplastic neurologic disorder antigens
  JOURNAL   Genomics 45 (2), 313-319 (1997)
   PUBMED   9344654
REFERENCE   9  (residues 1 to 180)
  AUTHORS   Buckanovich RJ and Darnell RB.
  TITLE     The neuronal RNA binding protein Nova-1 recognizes specific RNA
            targets in vitro and in vivo
  JOURNAL   Mol Cell Biol 17 (6), 3194-3201 (1997)
   PUBMED   9154818
REFERENCE   10 (residues 1 to 180)
  AUTHORS   Buckanovich RJ, Yang YY and Darnell RB.
  TITLE     The onconeural antigen Nova-1 is a neuron-specific RNA-binding
            protein, the activity of which is inhibited by paraneoplastic
            antibodies
  JOURNAL   J Neurosci 16 (3), 1114-1122 (1996)
   PUBMED   8558240
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156636.2 and AC108802.15.
            
            On Jun 26, 2018 this sequence version replaced XP_006516217.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.3627676.1,
                                           SRR11927935.2737479.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..180
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 21.46 cM"
     Protein         1..180
                     /product="RNA-binding protein Nova-1 isoform 6"
                     /note="RNA-binding protein Nova-1; ventral neuron-specific
                     protein 1; neuro-oncological ventral antigen 1"
                     /calculated_mol_wt=19248
     Region          1..44
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKN6.2)"
     Region          27..43
                     /region_name="Bipartite nuclear localization signal.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKN6.2)"
     Region          49..121
                     /region_name="KH-I_NOVA_rpt1"
                     /note="first type I K homology (KH) RNA-binding domain
                     found in the family of neuro-oncological ventral antigen
                     (Nova); cd22435"
                     /db_xref="CDD:411863"
     Site            order(61..63,65..69,72..73,83..85,87..89,98)
                     /site_type="other"
                     /note="RNA binding site [nucleotide binding]"
                     /db_xref="CDD:411863"
     Region          139..171
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JKN6.2)"
     Site            154
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:15933722; propagated from
                     UniProtKB/Swiss-Prot (Q9JKN6.2)"
     CDS             1..180
                     /gene="Nova1"
                     /gene_synonym="9430099M15Rik; G630039L02; Nova-1"
                     /coded_by="NM_001364639.1:17..559"
                     /note="isoform 6 is encoded by transcript variant 7"
                     /db_xref="GeneID:664883"
                     /db_xref="MGI:MGI:104297"
ORIGIN      
        1 mmaaapiqqn gthtgvpidl dppdsrkrpl eappeagstk rtntgedgqy flkvlipsya
       61 agsiigkggq tivqlqketg atiklskskd fypgttervc liqgtiealn avhgfiaeki
      121 rempqnvakt epvsilqpqt tvnpdrikqt lpssptttks spsdpmttsr anqkhsswit
//
LOCUS       NP_001397151             546 aa            linear   ROD 09-OCT-2023
DEFINITION  nuclear respiratory factor 1 isoform g [Mus musculus].
ACCESSION   NP_001397151 XP_011239346
VERSION     NP_001397151.1
DBSOURCE    REFSEQ: accession NM_001410222.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 546)
  AUTHORS   Cheng C, Tian Y, Yang R, Guo W, Xiao K, Zhang F, Tian J, Deng Z,
            Yang W, Yang H and Zhou Z.
  TITLE     miR-5581 Contributes to Osteoarthritis by Targeting NRF1 to Disturb
            the Proliferation and Functions of Chondrocytes
  JOURNAL   Am J Pathol 193 (9), 1234-1247 (2023)
   PUBMED   37611970
  REMARK    GeneRIF: miR-5581 Contributes to Osteoarthritis by Targeting NRF1
            to Disturb the Proliferation and Functions of Chondrocytes.
REFERENCE   2  (residues 1 to 546)
  AUTHORS   Meng Z, Liang B, Wu Y, Liu C, Wang H, Du Y, Gan L, Gao E, Lau WB,
            Christopher TA, Lopez BL, Koch WJ, Ma X, Zhao F, Wang Y and Zhao J.
  TITLE     Hypoadiponectinemia-induced upregulation of microRNA449b
            downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury
            in diabetic mice
  JOURNAL   J Mol Cell Cardiol 182, 1-14 (2023)
   PUBMED   37437402
  REMARK    GeneRIF: Hypoadiponectinemia-induced upregulation of microRNA449b
            downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury
            in diabetic mice.
REFERENCE   3  (residues 1 to 546)
  AUTHORS   Zhao T, Zhang J, Lei H, Meng Y, Cheng H, Zhao Y, Geng G, Mu C, Chen
            L, Liu Q, Luo Q, Zhang C, Long Y, Su J, Wang Y, Li Z, Sun J, Chen
            G, Li Y, Liao X, Shang Y, Hu G, Chen Q and Zhu Y.
  TITLE     NRF1-mediated mitochondrial biogenesis antagonizes innate antiviral
            immunity
  JOURNAL   EMBO J 42 (16), e113258 (2023)
   PUBMED   37409632
  REMARK    GeneRIF: NRF1-mediated mitochondrial biogenesis antagonizes innate
            antiviral immunity.
REFERENCE   4  (residues 1 to 546)
  AUTHORS   Akl MG, Baccetto R, Stebbings BM, Li L and Widenmaier SB.
  TITLE     Euglycemia is affected by stress defense factor hepatocyte NRF1,
            but not NRF2
  JOURNAL   Biochem Biophys Res Commun 668, 96-103 (2023)
   PUBMED   37245295
  REMARK    GeneRIF: Euglycemia is affected by stress defense factor hepatocyte
            NRF1, but not NRF2.
REFERENCE   5  (residues 1 to 546)
  AUTHORS   Akl MG, Li L, Baccetto R, Phanse S, Zhang Q, Trites MJ, McDonald S,
            Aoki H, Babu M and Widenmaier SB.
  TITLE     Complementary gene regulation by NRF1 and NRF2 protects against
            hepatic cholesterol overload
  JOURNAL   Cell Rep 42 (4), 112399 (2023)
   PUBMED   37060561
  REMARK    GeneRIF: Complementary gene regulation by NRF1 and NRF2 protects
            against hepatic cholesterol overload.
            Erratum:[Cell Rep. 2023 Jul 25;42(7):112872. PMID: 37454293]
REFERENCE   6  (residues 1 to 546)
  AUTHORS   Carmona MC, Iglesias R, Obregon MJ, Darlington GJ, Villarroya F and
            Giralt M.
  TITLE     Mitochondrial biogenesis and thyroid status maturation in brown fat
            require CCAAT/enhancer-binding protein alpha
  JOURNAL   J Biol Chem 277 (24), 21489-21498 (2002)
   PUBMED   11940593
REFERENCE   7  (residues 1 to 546)
  AUTHORS   Huo L and Scarpulla RC.
  TITLE     Mitochondrial DNA instability and peri-implantation lethality
            associated with targeted disruption of nuclear respiratory factor 1
            in mice
  JOURNAL   Mol Cell Biol 21 (2), 644-654 (2001)
   PUBMED   11134350
REFERENCE   8  (residues 1 to 546)
  AUTHORS   Schaefer L, Engman H and Miller JB.
  TITLE     Coding sequence, chromosomal localization, and expression pattern
            of Nrf1: the mouse homolog of Drosophila erect wing
  JOURNAL   Mamm Genome 11 (2), 104-110 (2000)
   PUBMED   10656923
REFERENCE   9  (residues 1 to 546)
  AUTHORS   Huo L and Scarpulla RC.
  TITLE     Multiple 5'-untranslated exons in the nuclear respiratory factor 1
            gene span 47 kb and contribute to transcript heterogeneity and
            translational efficiency
  JOURNAL   Gene 233 (1-2), 213-224 (1999)
   PUBMED   10375638
REFERENCE   10 (residues 1 to 546)
  AUTHORS   Virbasius CA, Virbasius JV and Scarpulla RC.
  TITLE     NRF-1, an activator involved in nuclear-mitochondrial interactions,
            utilizes a new DNA-binding domain conserved in a family of
            developmental regulators
  JOURNAL   Genes Dev 7 (12A), 2431-2445 (1993)
   PUBMED   8253388
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134897.4 and AC153632.2.
            
            On Aug 1, 2022 this sequence version replaced XP_011239346.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422600.925225.1,
                                           SRR13422590.463995.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..546
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 12.47 cM"
     Protein         1..546
                     /product="nuclear respiratory factor 1 isoform g"
                     /note="NRF-1; alpha-pal; alpha palindromic-binding
                     protein"
                     /calculated_mol_wt=58438
     Region          87..295
                     /region_name="Nrf1_DNA-bind"
                     /note="NLS-binding and DNA-binding and dimerization
                     domains of Nrf1; pfam10491"
                     /db_xref="CDD:402218"
     Region          462..537
                     /region_name="TGS_YchF_OLA1"
                     /note="TGS (ThrRS, GTPase and SpoT) domain found in the
                     YchF/OLA1 family proteins; cd04867"
                     /db_xref="CDD:340516"
     Site            519
                     /site_type="other"
                     /note="key conserved lysine K48"
                     /db_xref="CDD:340516"
     CDS             1..546
                     /gene="Nrf1"
                     /gene_synonym="D6Ertd415e"
                     /coded_by="NM_001410222.1:274..1914"
                     /note="isoform g is encoded by transcript variant 12"
                     /db_xref="GeneID:18181"
                     /db_xref="MGI:MGI:1332235"
ORIGIN      
        1 meehgvtqte hmatieahav aqqvqqvhva tytehsmlsa dedspssped tsyddsdiln
       61 staadevtah laaavlgikp rashilgpvg maaaaavatg kkrkrphvfe snpsirkrqq
      121 trllrklrat ldeyttrvgq qaivlcisps kpnpvfkvfg aaplenvvrk yksmiledle
      181 salaehapap qevnselppl tidgipvsvd kmtqaqlraf ipemlkystg rgkpgwgkes
      241 ckpiwwpedi pwanvrsdvr teeqkqrvsw tqalrtivkn cykqhgredl lyafedqqtq
      301 tqattthsia hlvpsqtvvq tfsnpdgtvs liqvgtgatv atladaselp ttvtvaqvny
      361 savadgeveq nwatlqggem tiqttqasea tqavaslaea avaasqemqq gatvtmalns
      421 eaaahavatl aeatlqgggq ivlsgetaaa vgaltgvqda ngpdgvhawt iskavtapqa
      481 agkihtdfgk gfimaevmkd edlkeessen aakaagkykq qgrayvvedg diiffkfnsp
      541 qqlkkk
//
LOCUS       NP_001351356             548 aa            linear   ROD 09-OCT-2023
DEFINITION  pro-neuregulin-1, membrane-bound isoform isoform 8 [Mus musculus].
ACCESSION   NP_001351356
VERSION     NP_001351356.1
DBSOURCE    REFSEQ: accession NM_001364427.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 548)
  AUTHORS   Mikami Y, Iwase F, Ohshima D, Tomida T and Adachi-Akahane S.
  TITLE     Compensatory role of neuregulin-1 in diabetic cardiomyopathy
  JOURNAL   J Pharmacol Sci 153 (3), 130-141 (2023)
   PUBMED   37770154
  REMARK    GeneRIF: Compensatory role of neuregulin-1 in diabetic
            cardiomyopathy.
REFERENCE   2  (residues 1 to 548)
  AUTHORS   Qiao XY, Wang Y, Zhang W, Li Q, Liu C, Dao JJ, Qiao CM, Cui C, Shen
            YQ and Zhao WJ.
  TITLE     Involvement of CXCL10 in Neuronal Damage under the Condition of
            Spinal Cord Injury and the Potential Therapeutic Effect of Nrg1
  JOURNAL   J Integr Neurosci 22 (4), 96 (2023)
   PUBMED   37519170
  REMARK    GeneRIF: Involvement of CXCL10 in Neuronal Damage under the
            Condition of Spinal Cord Injury and the Potential Therapeutic
            Effect of Nrg1.
REFERENCE   3  (residues 1 to 548)
  AUTHORS   Liu H, Lu P, He S, Luo Y, Fang Y, Benkaci S, Wu B, Wang Y and Zhou
            B.
  TITLE     beta-Catenin regulates endocardial cushion growth by suppressing
            p21
  JOURNAL   Life Sci Alliance 6 (9), e202302163 (2023)
   PUBMED   37385754
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 548)
  AUTHORS   Kong L, Hassinan CW, Gerstner F, Buettner JM, Petigrow JB, Valdivia
            DO, Chan-Cortes MH, Mistri A, Cao A, McGaugh SA, Denton M, Brown S,
            Ross J, Schwab MH, Simon CM and Sumner CJ.
  TITLE     Boosting neuregulin 1 type-III expression hastens SMA motor axon
            maturation
  JOURNAL   Acta Neuropathol Commun 11 (1), 53 (2023)
   PUBMED   36997967
  REMARK    GeneRIF: Boosting neuregulin 1 type-III expression hastens SMA
            motor axon maturation.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 548)
  AUTHORS   Zhang X, Xiao G, Johnson C, Cai Y, Horowitz ZK, Mennicke C, Coffey
            R, Haider M, Threadgill D, Eliscu R, Oldham MC, Greenbaum A and
            Ghashghaei HT.
  TITLE     Bulk and mosaic deletions of Egfr reveal regionally defined
            gliogenesis in the developing mouse forebrain
  JOURNAL   iScience 26 (3), 106242 (2023)
   PUBMED   36915679
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 548)
  AUTHORS   Gassmann M, Casagranda F, Orioli D, Simon H, Lai C, Klein R and
            Lemke G.
  TITLE     Aberrant neural and cardiac development in mice lacking the ErbB4
            neuregulin receptor
  JOURNAL   Nature 378 (6555), 390-394 (1995)
   PUBMED   7477376
REFERENCE   7  (residues 1 to 548)
  AUTHORS   Meyer,D. and Birchmeier,C.
  TITLE     Multiple essential functions of neuregulin in development
  JOURNAL   Nature 378 (6555), 386-390 (1995)
   PUBMED   7477375
  REMARK    Erratum:[Nature 1995 Dec 14;378(6558):753]
REFERENCE   8  (residues 1 to 548)
  AUTHORS   Moscoso LM, Chu GC, Gautam M, Noakes PG, Merlie JP and Sanes JR.
  TITLE     Synapse-associated expression of an acetylcholine receptor-inducing
            protein, ARIA/heregulin, and its putative receptors, ErbB2 and
            ErbB3, in developing mammalian muscle
  JOURNAL   Dev Biol 172 (1), 158-169 (1995)
   PUBMED   7589796
REFERENCE   9  (residues 1 to 548)
  AUTHORS   Yang Y, Spitzer E, Meyer D, Sachs M, Niemann C, Hartmann G, Weidner
            KM, Birchmeier C and Birchmeier W.
  TITLE     Sequential requirement of hepatocyte growth factor and neuregulin
            in the morphogenesis and differentiation of the mammary gland
  JOURNAL   J Cell Biol 131 (1), 215-226 (1995)
   PUBMED   7559778
REFERENCE   10 (residues 1 to 548)
  AUTHORS   Ho WH, Armanini MP, Nuijens A, Phillips HS and Osheroff PL.
  TITLE     Sensory and motor neuron-derived factor. A novel heregulin variant
            highly expressed in sensory and motor neurons
  JOURNAL   J Biol Chem 270 (24), 14523-14532 (1995)
   PUBMED   7782315
  REMARK    Erratum:[J Biol Chem. 1995 Nov 3;270(44):26722. PMID: 7592900]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132407.3 and AC127374.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.233502.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..548
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 18.75 cM"
     Protein         1..548
                     /product="pro-neuregulin-1, membrane-bound isoform isoform
                     8"
                     /note="heregulin; type III neuregulin 1; type I neuregulin
                     1; pro-neuregulin-1, membrane-bound isoform"
                     /calculated_mol_wt=60012
     Region          353..>510
                     /region_name="Neuregulin"
                     /note="Neuregulin family; pfam02158"
                     /db_xref="CDD:426627"
     CDS             1..548
                     /gene="Nrg1"
                     /gene_synonym="6030402G23Rik; ARIA; D230005F13Rik; GGF;
                     GGFII; Hgl; HRG; HRGalpha; NDF; Pro-NRG1; SMDF"
                     /coded_by="NM_001364427.1:641..2287"
                     /note="isoform 8 is encoded by transcript variant 8"
                     /db_xref="GeneID:211323"
                     /db_xref="MGI:MGI:96083"
ORIGIN      
        1 meiyppdmse gaggrsssps tqlsadpsld glpaaehmpd thtedgrspg llglavpccv
       61 cleaerlrgc lnsekicivp ilaclvslcl ciaglkwvfv dkifeydspt hldpgglgqd
      121 pvisldptaa savlvsseay tspvskaqse aeahvtgqgd hvavasepsa vptrknrlsa
      181 fpplhstppp fpspartpev rtpksgtqpq ttetnlqtap klstststtg tshlikcaek
      241 ektfcvngge cfmvkdlsnp srylckcpne ftgdrcqnyv masfymtsrr krqetekple
      301 rkldhslvke tkhlgiefme aeelyqkrvl titgiciall vvgimcvvay cktkkqrqkl
      361 hdrlrqslrs ernnmvnian gphhpnpppe nvqlvnqyvs knvissehiv erevetsfst
      421 shytstahhs ttvtqtpshs wsnghtesii seshsvimms svensrhssp aggprgrlhg
      481 lggprecnsf lrharetpds yrdsphserh nliaelrrnk ayrskcmqie lsathlrsss
      541 iphlgfil
//
LOCUS       NP_033148                764 aa            linear   ROD 09-OCT-2023
DEFINITION  DNA-binding protein SATB1 isoform 1 [Mus musculus].
ACCESSION   NP_033148
VERSION     NP_033148.2
DBSOURCE    REFSEQ: accession NM_009122.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 764)
  AUTHORS   Naito T, Ise M, Tanaka Y, Kohwi-Shigematsu T and Kondo M.
  TITLE     Crucial Roles of SATB1 in Regulation of Thymocyte Migration after
            Positive Selection
  JOURNAL   J Immunol 211 (2), 209-218 (2023)
   PUBMED   37256264
  REMARK    GeneRIF: Crucial Roles of SATB1 in Regulation of Thymocyte
            Migration after Positive Selection.
REFERENCE   2  (residues 1 to 764)
  AUTHORS   Nomura A, Kobayashi T, Seo W, Ohno-Oishi M, Kakugawa K, Muroi S,
            Yoshida H, Endo TA, Moro K and Taniuchi I.
  TITLE     Identification of a novel enhancer essential for Satb1 expression
            in TH2 cells and activated ILC2s
  JOURNAL   Life Sci Alliance 6 (8), e202301897 (2023)
   PUBMED   37193606
  REMARK    GeneRIF: Identification of a novel enhancer essential for Satb1
            expression in TH2 cells and activated ILC2s.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 764)
  AUTHORS   Knowles SJ, Stafford AM, Zaman T, Angara K, Williams MR, Newbern JM
            and Vogt D.
  TITLE     Distinct hyperactive RAS/MAPK alleles converge on common GABAergic
            interneuron core programs
  JOURNAL   Development 150 (10) (2023)
   PUBMED   37254876
REFERENCE   4  (residues 1 to 764)
  AUTHORS   Wang B, Ji L and Bian Q.
  TITLE     SATB1 regulates 3D genome architecture in T cells by constraining
            chromatin interactions surrounding CTCF-binding sites
  JOURNAL   Cell Rep 42 (4), 112323 (2023)
   PUBMED   37000624
  REMARK    GeneRIF: SATB1 regulates 3D genome architecture in T cells by
            constraining chromatin interactions surrounding CTCF-binding sites.
REFERENCE   5  (residues 1 to 764)
  AUTHORS   Vasilopoulos N, Kaplanian A, Vinos M, Katsaiti Y, Christodoulou O,
            Denaxa M and Skaliora I.
  TITLE     The role of selective SATB1 deletion in somatostatin expressing
            interneurons on endogenous network activity and the transition to
            epilepsy
  JOURNAL   J Neurosci Res 101 (4), 424-447 (2023)
   PUBMED   36541427
  REMARK    GeneRIF: The role of selective SATB1 deletion in somatostatin
            expressing interneurons on endogenous network activity and the
            transition to epilepsy.
REFERENCE   6  (residues 1 to 764)
  AUTHORS   Seo J, Lozano MM and Dudley JP.
  TITLE     Nuclear matrix binding regulates SATB1-mediated transcriptional
            repression
  JOURNAL   J Biol Chem 280 (26), 24600-24609 (2005)
   PUBMED   15851481
  REMARK    GeneRIF: SATB1-mediated transcriptional repression is regulated by
            nuclear matrix binding
REFERENCE   7  (residues 1 to 764)
  AUTHORS   Nie H, Maika SD, Tucker PW and Gottlieb PD.
  TITLE     A role for SATB1, a nuclear matrix association region-binding
            protein, in the development of CD8SP thymocytes and peripheral T
            lymphocytes
  JOURNAL   J Immunol 174 (8), 4745-4752 (2005)
   PUBMED   15814699
  REMARK    GeneRIF: essential role for SATB1 late in the development and
            maturation of CD8SP T cells
REFERENCE   8  (residues 1 to 764)
  AUTHORS   Cai S, Han HJ and Kohwi-Shigematsu T.
  TITLE     Tissue-specific nuclear architecture and gene expression regulated
            by SATB1
  JOURNAL   Nat Genet 34 (1), 42-51 (2003)
   PUBMED   12692553
  REMARK    GeneRIF: in thymocyte nuclei, SATB1 has a cage-like 'network'
            distribution circumscribing heterochromatin and selectively tethers
            specialized DNA sequences onto its network
REFERENCE   9  (residues 1 to 764)
  AUTHORS   Alvarez JD, Yasui DH, Niida H, Joh T, Loh DY and Kohwi-Shigematsu
            T.
  TITLE     The MAR-binding protein SATB1 orchestrates temporal and spatial
            expression of multiple genes during T-cell development
  JOURNAL   Genes Dev 14 (5), 521-535 (2000)
   PUBMED   10716941
REFERENCE   10 (residues 1 to 764)
  AUTHORS   Nakagomi K, Kohwi Y, Dickinson LA and Kohwi-Shigematsu T.
  TITLE     A novel DNA-binding motif in the nuclear matrix attachment
            DNA-binding protein SATB1
  JOURNAL   Mol Cell Biol 14 (3), 1852-1860 (1994)
   PUBMED   8114718
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK037740.1, AK134040.1, AK081385.1, AC131975.28 and AW045567.1.
            
            On Jul 29, 2009 this sequence version replaced NP_033148.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1-4 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK037740.1, U05252.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..764
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 26.81 cM"
     Protein         1..764
                     /product="DNA-binding protein SATB1 isoform 1"
                     /note="DNA-binding protein Satb1"
                     /calculated_mol_wt=85749
     Region          1..56
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60611.2)"
     Region          20..40
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60611.2)"
     Region          72..170
                     /region_name="ULD"
                     /note="Ubiquitin-like oligomerization domain of SATB;
                     pfam16534"
                     /db_xref="CDD:435405"
     Site            order(75,77,94..98,100,132,134,137..138,144..147,155..156,
                     159..161,163..164)
                     /site_type="other"
                     /note="tetramer interface [polypeptide binding]"
                     /db_xref="CDD:211426"
     Site            136
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q01826; propagated from
                     UniProtKB/Swiss-Prot (Q60611.2)"
     Region          139..143
                     /region_name="Protein interaction. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60611.2)"
     Region          176..247
                     /region_name="CUTL"
                     /note="CUT1-like DNA-binding domain of SATB; pfam16557"
                     /db_xref="CDD:435427"
     Site            185
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q01826; propagated from
                     UniProtKB/Swiss-Prot (Q60611.2)"
     Region          224..278
                     /region_name="Nuclear matrix targeting sequence (NMTS)"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60611.2)"
     Region          224..278
                     /region_name="Nuclear matrix targeting sequence (NMTS).
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60611.2)"
     Site            254..255
                     /site_type="cleavage"
                     /note="Cleavage, by caspases; propagated from
                     UniProtKB/Swiss-Prot (Q60611.2)"
     Region          266..307
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60611.2)"
     Region          372..444
                     /region_name="CUT"
                     /note="CUT domain; pfam02376"
                     /db_xref="CDD:426745"
     Region          450..474
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60611.2)"
     Region          497..567
                     /region_name="CUT"
                     /note="CUT domain; pfam02376"
                     /db_xref="CDD:426745"
     Region          591..650
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60611.2)"
     Site            638
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q60611.2)"
     Region          645..702
                     /region_name="HOX"
                     /note="Homeodomain; smart00389"
                     /db_xref="CDD:197696"
     Site            order(647..650,652,670,676,689,691..692,695..696,698..700,
                     702..703)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     Site            order(648,651,692,695..696,699)
                     /site_type="other"
                     /note="specific DNA base contacts [nucleotide binding]"
                     /db_xref="CDD:238039"
     CDS             1..764
                     /gene="Satb1"
                     /gene_synonym="2610306G12Rik"
                     /coded_by="NM_009122.2:213..2507"
                     /note="isoform 1 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS28876.1"
                     /db_xref="GeneID:20230"
                     /db_xref="MGI:MGI:105084"
ORIGIN      
        1 mdhlneatqg kehsemsnnv sdpkgppaki arleqngspl grgrlgstgg kmqgvplkhs
       61 ghlmktnlrk gtmlpvfcvv ehyenaieyd ckeehaefvl vrkdmlfnql iemallslgy
      121 shssaaqakg liqvgkwnpv plsyvtdapd atvadmlqdv yhvvtlkiql hscpkledlp
      181 peqwshttvr nalkdllkdm nqsslakecp lsqsmissiv nstyyanvsa akcqefgrwy
      241 khfkktkdmm vemdslsels qqganhvnfg qqpvpgntae qppspaqlsh gsqpsvrtpl
      301 pnlhpglvst pispqlvnqq lvmaqllnqq yavnrllaqq slnqqylnhp ppvsrsmnkp
      361 leqqvstnte vsseiyqwvr delkragisq avfarvafnr tqgllseilr keedpktasq
      421 sllvnlramq nflqlpeaer driyqderer slnaasamgp apllstppsr ppqvktatla
      481 terngkpenn tmninasiyd eiqqemkrak vsqalfakva atksqgwlce llrwkedpsp
      541 enrtlwenls mirrflslpq perdaiyeqe snavhhhgdr pphiihvpae qiqqqqqqqq
      601 qqqqqqqppp pppqpqpqpq agprlpprqp tvassaesde enrqktrprt kisvealgil
      661 qsfiqdvgly pdeeaiqtls aqldlpkyti ikffqnqryy lkhhgklkdn sglevdvaey
      721 kdeellkdle esvqdknant lfsvkleeel svegstdvna dlkd
//
LOCUS       NP_963999               2582 aa            linear   ROD 09-OCT-2023
DEFINITION  chromodomain-helicase-DNA-binding protein 8 [Mus musculus].
ACCESSION   NP_963999 XP_006519539 XP_619244 XP_913085 XP_992713
VERSION     NP_963999.2
DBSOURCE    REFSEQ: accession NM_201637.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 2582)
  AUTHORS   Chatterjee I, Getselter D, Ghanayem N, Harari R, Davis L, Bel S and
            Elliott E.
  TITLE     CHD8 regulates gut epithelial cell function and affects
            autism-related behaviors through the gut-brain axis
  JOURNAL   Transl Psychiatry 13 (1), 305 (2023)
   PUBMED   37783686
  REMARK    GeneRIF: CHD8 regulates gut epithelial cell function and affects
            autism-related behaviors through the gut-brain axis.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 2582)
  AUTHORS   Kawamura A and Nishiyama M.
  TITLE     Deletion of the autism-related gene Chd8 alters activity-dependent
            transcriptional responses in mouse postmitotic neurons
  JOURNAL   Commun Biol 6 (1), 593 (2023)
   PUBMED   37268684
  REMARK    GeneRIF: Deletion of the autism-related gene Chd8 alters
            activity-dependent transcriptional responses in mouse postmitotic
            neurons.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 2582)
  AUTHORS   Munz M, Bharioke A, Kosche G, Moreno-Juan V, Brignall A, Rodrigues
            TM, Graff-Meyer A, Ulmer T, Haeuselmann S, Pavlinic D, Ledergerber
            N, Gross-Scherf B, Rozsa B, Krol J, Picelli S, Cowan CS and Roska
            B.
  TITLE     Pyramidal neurons form active, transient, multilayered circuits
            perturbed by autism-associated mutations at the inception of
            neocortex
  JOURNAL   Cell 186 (9), 1930-1949 (2023)
   PUBMED   37071993
REFERENCE   4  (residues 1 to 2582)
  AUTHORS   Dong C, Zhao C, Chen X, Berry K, Wang J, Zhang F, Liao Y, Han R,
            Ogurek S, Xu L, Zhang L, Lin Y, Zhou W, Xin M, Lim DA, Campbell K,
            Nakafuku M, Waclaw RR and Lu QR.
  TITLE     Conserved and Distinct Functions of the Autism-Related Chromatin
            Remodeler CHD8 in Embryonic and Adult Forebrain Neurogenesis
  JOURNAL   J Neurosci 42 (44), 8373-8392 (2022)
   PUBMED   36127134
  REMARK    GeneRIF: Conserved and Distinct Functions of the Autism-Related
            Chromatin Remodeler CHD8 in Embryonic and Adult Forebrain
            Neurogenesis.
REFERENCE   5  (residues 1 to 2582)
  AUTHORS   Tu Z, Fan C, Davis AK, Hu M, Wang C, Dandamudi A, Seu KG, Kalfa TA,
            Lu QR and Zheng Y.
  TITLE     Autism-associated chromatin remodeler CHD8 regulates erythroblast
            cytokinesis and fine-tunes the balance of Rho GTPase signaling
  JOURNAL   Cell Rep 40 (2), 111072 (2022)
   PUBMED   35830790
  REMARK    GeneRIF: Autism-associated chromatin remodeler CHD8 regulates
            erythroblast cytokinesis and fine-tunes the balance of Rho GTPase
            signaling.
REFERENCE   6  (residues 1 to 2582)
  AUTHORS   Ishihara K, Oshimura M and Nakao M.
  TITLE     CTCF-dependent chromatin insulator is linked to epigenetic
            remodeling
  JOURNAL   Mol Cell 23 (5), 733-742 (2006)
   PUBMED   16949368
REFERENCE   7  (residues 1 to 2582)
  AUTHORS   Cobellis G, Nicolaus G, Iovino M, Romito A, Marra E, Barbarisi M,
            Sardiello M, Di Giorgio FP, Iovino N, Zollo M, Ballabio A and
            Cortese R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   8  (residues 1 to 2582)
  AUTHORS   Nishiyama M, Nakayama K, Tsunematsu R, Tsukiyama T, Kikuchi A and
            Nakayama KI.
  TITLE     Early embryonic death in mice lacking the beta-catenin-binding
            protein Duplin
  JOURNAL   Mol Cell Biol 24 (19), 8386-8394 (2004)
   PUBMED   15367660
REFERENCE   9  (residues 1 to 2582)
  AUTHORS   Kobayashi M, Kishida S, Fukui A, Michiue T, Miyamoto Y, Okamoto T,
            Yoneda Y, Asashima M and Kikuchi A.
  TITLE     Nuclear localization of Duplin, a beta-catenin-binding protein, is
            essential for its inhibitory activity on the Wnt signaling pathway
  JOURNAL   J Biol Chem 277 (8), 5816-5822 (2002)
   PUBMED   11744694
REFERENCE   10 (residues 1 to 2582)
  AUTHORS   Sakamoto I, Kishida S, Fukui A, Kishida M, Yamamoto H, Hino S,
            Michiue T, Takada S, Asashima M and Kikuchi A.
  TITLE     A novel beta-catenin-binding protein inhibits
            beta-catenin-dependent Tcf activation and axis formation
  JOURNAL   J Biol Chem 275 (42), 32871-32878 (2000)
   PUBMED   10921920
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC126037.4 and AC159323.3.
            
            On or before Jun 20, 2019 this sequence version replaced
            XP_006519539.1, XP_619244.2, XP_913085.1, XP_992713.1, NP_963999.1.
            
            Summary: This gene encodes a member of the
            chromodomain-helicase-DNA binding protein family, which is
            characterized by a SNF2-like domain and two chromatin organization
            modifier domains. The encoded protein also contains brahma and
            kismet domains, which is common to the subfamily of
            chromodomain-helicase-DNA binding proteins to which this protein
            belongs. In mammals, this gene has been shown to function in
            several processes including transcriptional regulation, epigenetic
            remodeling, promotion of cell proliferation, and regulation of RNA
            synthesis. Knockout of this gene causes early embryonic lethality
            due to widespread apoptosis. Heterozygous loss of function
            mutations result in autism spectrum disorder-like behaviors that
            include increased anxiety, repetitive behavior, and altered social
            behavior. [provided by RefSeq, Dec 2016].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: DQ190419.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMN00849374,
                                    SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2582
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 26.84 cM"
     Protein         1..2582
                     /product="chromodomain-helicase-DNA-binding protein 8"
                     /EC_number="3.6.4.12"
                     /note="axis duplication inhibitor; helicase with SNF2
                     domain 1; ATP-dependent helicase CHD8"
                     /calculated_mol_wt=290718
     Region          22..111
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q09XV5.1)"
     Region          61..>421
                     /region_name="SP1-4_N"
                     /note="N-terminal domain of transcription factor
                     Specificity Proteins (SP) 1-4; cl41773"
                     /db_xref="CDD:425404"
     Region          136..155
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q09XV5.1)"
     Region          253..283
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q09XV5.1)"
     Region          349..377
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q09XV5.1)"
     Site            434
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9HCK8; propagated from
                     UniProtKB/Swiss-Prot (Q09XV5.1)"
     Region          <449..624
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Region          475..585
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q09XV5.1)"
     Site            555
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q09XV5.1)"
     Site            564
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9HCK8; propagated from
                     UniProtKB/Swiss-Prot (Q09XV5.1)"
     Region          598..617
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q09XV5.1)"
     Region          640..705
                     /region_name="CD1_tandem_CHD5-9_like"
                     /note="repeat 1 of the paired tandem chromodomains of
                     chromodomain helicase DNA-binding protein 5-9, and similar
                     proteins; cd18668"
                     /db_xref="CDD:349315"
     Site            order(644,674,676..677,681)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:349315"
     Region          723..781
                     /region_name="CD2_tandem_CHD5-9_like"
                     /note="repeat 2 of the paired tandem chromodomains of
                     chromodomain helicase DNA-binding protein 5-9, and similar
                     proteins; cd18663"
                     /db_xref="CDD:349310"
     Site            order(748,765)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:349310"
     Region          812..>1411
                     /region_name="PLN03142"
                     /note="Probable chromatin-remodeling complex ATPase chain;
                     Provisional"
                     /db_xref="CDD:215601"
     Region          813..1034
                     /region_name="DEAD-like_helicase_N"
                     /note="N-terminal helicase domain of the DEAD-box helicase
                     superfamily; cl28899"
                     /db_xref="CDD:452890"
     Site            order(840..846,950)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:350670"
     Region          950..953
                     /region_name="DEAH box.
                     /evidence=ECO:0000255|HAMAP-Rule:MF_03071"
                     /note="propagated from UniProtKB/Swiss-Prot (Q09XV5.1)"
     Site            1422
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q09XV5.1)"
     Site            1426
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q09XV5.1)"
     Region          1694..1715
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q09XV5.1)"
     Region          1791..2304
                     /region_name="Interaction with FAM124B.
                     /evidence=ECO:0000255|HAMAP-Rule:MF_03071"
                     /note="propagated from UniProtKB/Swiss-Prot (Q09XV5.1)"
     Site            1978
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9HCK8; propagated from
                     UniProtKB/Swiss-Prot (Q09XV5.1)"
     Site            1980
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9HCK8; propagated from
                     UniProtKB/Swiss-Prot (Q09XV5.1)"
     Region          1990..2019
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q09XV5.1)"
     Site            1995
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9HCK8; propagated from
                     UniProtKB/Swiss-Prot (Q09XV5.1)"
     Site            1997
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9JIX5; propagated from
                     UniProtKB/Swiss-Prot (Q09XV5.1)"
     Site            1999
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q09XV5.1)"
     Site            2010
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9HCK8; propagated from
                     UniProtKB/Swiss-Prot (Q09XV5.1)"
     Site            2040
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19144319; propagated from
                     UniProtKB/Swiss-Prot (Q09XV5.1)"
     Region          2045..2120
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q09XV5.1)"
     Site            2070
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9HCK8; propagated from
                     UniProtKB/Swiss-Prot (Q09XV5.1)"
     Site            2072
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9HCK8; propagated from
                     UniProtKB/Swiss-Prot (Q09XV5.1)"
     Site            2184
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9HCK8; propagated from
                     UniProtKB/Swiss-Prot (Q09XV5.1)"
     Region          2187..2233
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q09XV5.1)"
     Site            2202
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q09XV5.1)"
     Site            2204
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q09XV5.1)"
     Site            2206
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q09XV5.1)"
     Site            2213
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q09XV5.1)"
     Site            2217
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q09XV5.1)"
     Site            2225
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9JIX5; propagated from
                     UniProtKB/Swiss-Prot (Q09XV5.1)"
     Region          2311..2354
                     /region_name="BRK"
                     /note="BRK domain; pfam07533"
                     /db_xref="CDD:429518"
     Region          2381..2420
                     /region_name="BRK"
                     /note="BRK domain; cl02688"
                     /db_xref="CDD:445886"
     Region          2486..2582
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q09XV5.1)"
     Site            2520
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9HCK8; propagated from
                     UniProtKB/Swiss-Prot (Q09XV5.1)"
     CDS             1..2582
                     /gene="Chd8"
                     /gene_synonym="5830451P18Rik; Chd-8; Duplin; HELSNF1;
                     mKIAA1564"
                     /coded_by="NM_201637.3:300..8048"
                     /db_xref="CCDS:CCDS36919.1"
                     /db_xref="GeneID:67772"
                     /db_xref="MGI:MGI:1915022"
ORIGIN      
        1 madpimdlfd dpnlfgldsl tddsfnqvtq dpieealglp ssldsldqmn qdggggdvgn
       61 ssasdlvppp eetastelpk estapapesl tlhdyttqpt sqeqpaqpvl qtstptagll
      121 qvsksqeils qgnpfmgvsa tgvspsntgg qpsqsapkiv ilkappnssv tgthvaqiqa
      181 qgitstaqpl vagtanggkv tftkvltgtp lrpgvsivsg ntvlatkvpg nqaavqrivq
      241 psrpvkqlvl qpvkgsapag npgaagpplk pavtltstpt qgeskritlv lqqpqsggpq
      301 ghrhvvlgsl pgkivlqgnq laaltqakna qgqpakvvti qlqvqqpqqk iqivpqppss
      361 qpqpqpqppp saqpltlssv qqaqimgpgq npgqrlsvpl kmvlqpqags sqgassglsv
      421 vkvlsaseva alsspascap htagktgmee nrrlehqkkq ekanrivaea iararargeq
      481 niprvlnede lpsvrpeeeg ekkrrkkssg erlkeekpkk sktaaasktk gksklntitp
      541 vvgkkrkrnt ssdnsdvevm paqspredee ssiqkrrsnr qvkrkkyted ldikitddee
      601 eeevdvtgpi kpepilpepv qepdgetlps mqffvenpse edaaivdkvl smrvvkkelp
      661 sgqyteaeef fvkyknysyl hcewatisql ekdkrihqkl krfktkmaqm rhffhedeep
      721 fnpdyvevdr ildeshsvdk dngepviyyl vkwcslpyed stwelkedvd egkirefkri
      781 qsrhpelrrv nrpqanawkk lelsheyknr nqlreyqleg vnwllfnwyn rqnciladem
      841 glgktiqsia flqevynvgi hgpflviapl stitnweref ntwtemntiv yhgslasrqm
      901 iqqyemyckd srgrlipgay kfdalittfe milsdcpelr eiewrcviid eahrlknrnc
      961 klldslkhmd lehkvlltgt plqntveelf sllhflepsq fpseseflkd fgdlkteeqv
     1021 qklqailkpm mlrrlkedve knlapkqeti ieveltniqk kyyrailekn fsflskgagh
     1081 tnmpnllntm melrkccnhp ylingaeeki lmefreachi ipqdfhlqam vrsagklvli
     1141 dkllpklkag ghkvlifsqm vrcldiledy liqrrylyer idgrvrgnlr qaaidrfskp
     1201 dsdrfvfllc tragglginl taadtciifd sdwnpqndlq aqarchrigq skavkvyrli
     1261 trnsyeremf dkaslklgld kavlqsmsgr dgnitgiqqf skkeiedllr kgayaaimee
     1321 ddegskfcee didqillrrt ttitiesegk gstfakasfv asenrtdisl ddpnfwqkwa
     1381 kkadldmdll nsknnlvidt prvrkqtrhf stlkdddlve fsdlesedde rprsrrhdrh
     1441 htygrtdcfr vekhllvygw grwrdilshg rfkrrmterd veticrailv ycllhyrgde
     1501 niksfiwdli spaengktke lqnhsglsip vprgrkgkkv ksqstfdihk adwirkynpd
     1561 tlfqdesykk hlkhqcnkvl lrvrmlyylr qevigdqaek vlggaiasei diwfpvvdql
     1621 evpttwwdse adkslligvf khgyekyntm radpalcfle kagrpddkai aaehrvldnf
     1681 sdlvegidfd kdcedpeykp lqgppkdpdd egdplmmmde eisvidgeea qvtqqpghlf
     1741 wppgsaltar lrrlvtayqr sykreqmkme aaergdrrrr rceaafklke iarrekqqrw
     1801 trreqtdfyr vvstfgveyd pdnmqfhwdr frtfarldkk tdesltkyfh gfvamcrqvc
     1861 rlppaagdep pdpnlfiepi teerasrtly riellrrlre qvlchplled rlalcqppgl
     1921 elpkwwepvr hdgellrgaa rhgvsqtdcn imqdpdfsfl aarmnymqnh qagasaasls
     1981 rcstpllhqq ctsrtaspsp lrpdapveks peestvqvpn lesltlkled evvarsrlts
     2041 qdyevrvgss dtaplsrsvp pvklededds dseldlskls psssssssss ssssstdese
     2101 dekeekltad rsrpklydee sllsltmsqd gfpnedgeqm tpellllqer qrasewpkdr
     2161 vlinridlvc qavlsgkwps nrrsqevtag gilgpgnhll dspsltpged gdspvptprs
     2221 gsaasmaeee asavttaaaq ftklrrgmde keftvqikde eglkltfqkh rlmangvmgd
     2281 ghplfhkkkg nrkklvelev ecmeepnhld ldletripvi nkvdgtllvg deaprraele
     2341 mwlqghpefa vdprflayme errkqkwqrc kknnkaelnc lgmepvqpan srngkkghya
     2401 etafnrvlpg pvapenskkr vrrtrpdlsk mmalmqggst gslslhntfq hsssnlqsvs
     2461 slghssttsa slpfmpfvmg aaapphvdss tmlhhhhhhp hphhhhhhhp glrttgypss
     2521 patttsgtal rlptlqpedd deeedeeddd lsqgydsser dfsliddpmm pansdsseda
     2581 dd
//
LOCUS       NP_001349257             474 aa            linear   ROD 09-OCT-2023
DEFINITION  CUGBP Elav-like family member 4 isoform 46 [Mus musculus].
ACCESSION   NP_001349257 XP_017173285
VERSION     NP_001349257.1
DBSOURCE    REFSEQ: accession NM_001362328.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 474)
  AUTHORS   Salamon I, Park Y, Miskic T, Kopic J, Matteson P, Page NF, Roque A,
            McAuliffe GW, Favate J, Garcia-Forn M, Shah P, Judas M, Millonig
            JH, Kostovic I, De Rubeis S, Hart RP, Krsnik Z and Rasin MR.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    GeneRIF: Celf4 controls mRNA translation underlying synaptic
            development in the prenatal mammalian neocortex.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 474)
  AUTHORS   Shen Y, Zhang C, Xiao K, Liu D and Xie G.
  TITLE     CELF4 regulates spine formation and depression-like behaviors of
            mice
  JOURNAL   Biochem Biophys Res Commun 605, 39-44 (2022)
   PUBMED   35306363
  REMARK    GeneRIF: CELF4 regulates spine formation and depression-like
            behaviors of mice.
REFERENCE   3  (residues 1 to 474)
  AUTHORS   Moreau MX, Saillour Y, Cwetsch AW, Pierani A and Causeret F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   4  (residues 1 to 474)
  AUTHORS   Li C, Li X, Bi Z, Sugino K, Wang G, Zhu T and Liu Z.
  TITLE     Comprehensive transcriptome analysis of cochlear spiral ganglion
            neurons at multiple ages
  JOURNAL   Elife 9, e50491 (2020)
   PUBMED   31913118
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 474)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 474)
  AUTHORS   Ladd AN, Taffet G, Hartley C, Kearney DL and Cooper TA.
  TITLE     Cardiac tissue-specific repression of CELF activity disrupts
            alternative splicing and causes cardiomyopathy
  JOURNAL   Mol Cell Biol 25 (14), 6267-6278 (2005)
   PUBMED   15988035
  REMARK    GeneRIF: CELF protein activity is required for normal alternative
            splicing in the heart in vivo and normal CELF-mediated alternative
            splicing regulation is in turn required for normal cardiac
            function.
REFERENCE   7  (residues 1 to 474)
  AUTHORS   Meins M, Schlickum S, Wilhelm C, Missbach J, Yadav S, Glaser B,
            Grzmil M, Burfeind P and Laccone F.
  TITLE     Identification and characterization of murine Brunol4, a new member
            of the elav/bruno family
  JOURNAL   Cytogenet Genome Res 97 (3-4), 254-260 (2002)
   PUBMED   12438720
  REMARK    GeneRIF: cloning and characterization
REFERENCE   8  (residues 1 to 474)
  AUTHORS   Ladd AN, Charlet N and Cooper TA.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   9  (residues 1 to 474)
  AUTHORS   Good PJ, Chen Q, Warner SJ and Herring DC.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
REFERENCE   10 (residues 1 to 474)
  AUTHORS   Yulug IG, Egan SE, See CG and Fisher EM.
  TITLE     Mapping GRB2, a signal transduction gene in the human and the mouse
  JOURNAL   Genomics 22 (2), 313-318 (1994)
   PUBMED   7806216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121094.8 and AC144938.3.
            
            On Apr 12, 2018 this sequence version replaced XP_017173285.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.177295.1,
                                           SRR1660821.111324.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..474
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 13.92 cM"
     Protein         1..474
                     /product="CUGBP Elav-like family member 4 isoform 46"
                     /note="CUG-BP- and ETR-3-like factor 4; bruno-like protein
                     4; RNA-binding protein BRUNOL-4; bruno-like 4, RNA binding
                     protein"
                     /calculated_mol_wt=50589
     Region          49..135
                     /region_name="RRM1_CELF3_4_5_6"
                     /note="RNA recognition motif 1 (RRM1) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12632"
                     /db_xref="CDD:410041"
     Site            order(55,57,59..60,63,82,84,86,95..97,99,129,131)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410041"
     Region          140..220
                     /region_name="RRM2_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12635"
                     /db_xref="CDD:410043"
     Site            order(142,144,146..147,150,169,171,173,181..183,185,215,
                     217)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410043"
     Region          405..463
                     /region_name="RRM_SF"
                     /note="RNA recognition motif (RRM) superfamily; cl17169"
                     /db_xref="CDD:450164"
     CDS             1..474
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /coded_by="NM_001362328.1:531..1955"
                     /note="isoform 46 is encoded by transcript variant 48"
                     /db_xref="GeneID:108013"
                     /db_xref="MGI:MGI:1932407"
ORIGIN      
        1 myikmatlan gqadnaslst nglgsspgsa ghmnglshsp gnpstipmkd hdaiklfigq
       61 iprnldekdl kplfeefgki yeltvlkdrf tgmhkgcafl tyceresalk aqsalheqkt
      121 lpgmnrpiqv kpadsesrgd rklfvgmlnk qqseddvrrl feafgnieec tilrgpdgns
      181 kgcafvkyss haeaqaaina lhgsqtmpga ssslvvkfad tdkertmrrm qqmagqmgmf
      241 npmaipfgay gayaqalmqq qaalmasvaq ggylnpmaaf aaaqmqqmaa lnmnglaaap
      301 mtptsggstp pgitapavps ipspigvngf tglppqangq paaeavfang ihpypaqspt
      361 aadplqqaya gvqqyagpay paaygqisqa fpqpppmipq qqregpegcn lliyhlpqef
      421 gdaelmqmfl pfgfvsfdnp asaqtaiqam ngfqigmkrl kvqlkrpkda nrpy
//
LOCUS       NP_001349219             524 aa            linear   ROD 09-OCT-2023
DEFINITION  CUGBP Elav-like family member 4 isoform 15 [Mus musculus].
ACCESSION   NP_001349219
VERSION     NP_001349219.1
DBSOURCE    REFSEQ: accession NM_001362290.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 524)
  AUTHORS   Salamon I, Park Y, Miskic T, Kopic J, Matteson P, Page NF, Roque A,
            McAuliffe GW, Favate J, Garcia-Forn M, Shah P, Judas M, Millonig
            JH, Kostovic I, De Rubeis S, Hart RP, Krsnik Z and Rasin MR.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    GeneRIF: Celf4 controls mRNA translation underlying synaptic
            development in the prenatal mammalian neocortex.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 524)
  AUTHORS   Shen Y, Zhang C, Xiao K, Liu D and Xie G.
  TITLE     CELF4 regulates spine formation and depression-like behaviors of
            mice
  JOURNAL   Biochem Biophys Res Commun 605, 39-44 (2022)
   PUBMED   35306363
  REMARK    GeneRIF: CELF4 regulates spine formation and depression-like
            behaviors of mice.
REFERENCE   3  (residues 1 to 524)
  AUTHORS   Moreau MX, Saillour Y, Cwetsch AW, Pierani A and Causeret F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   4  (residues 1 to 524)
  AUTHORS   Li C, Li X, Bi Z, Sugino K, Wang G, Zhu T and Liu Z.
  TITLE     Comprehensive transcriptome analysis of cochlear spiral ganglion
            neurons at multiple ages
  JOURNAL   Elife 9, e50491 (2020)
   PUBMED   31913118
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 524)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 524)
  AUTHORS   Ladd AN, Taffet G, Hartley C, Kearney DL and Cooper TA.
  TITLE     Cardiac tissue-specific repression of CELF activity disrupts
            alternative splicing and causes cardiomyopathy
  JOURNAL   Mol Cell Biol 25 (14), 6267-6278 (2005)
   PUBMED   15988035
  REMARK    GeneRIF: CELF protein activity is required for normal alternative
            splicing in the heart in vivo and normal CELF-mediated alternative
            splicing regulation is in turn required for normal cardiac
            function.
REFERENCE   7  (residues 1 to 524)
  AUTHORS   Meins M, Schlickum S, Wilhelm C, Missbach J, Yadav S, Glaser B,
            Grzmil M, Burfeind P and Laccone F.
  TITLE     Identification and characterization of murine Brunol4, a new member
            of the elav/bruno family
  JOURNAL   Cytogenet Genome Res 97 (3-4), 254-260 (2002)
   PUBMED   12438720
  REMARK    GeneRIF: cloning and characterization
REFERENCE   8  (residues 1 to 524)
  AUTHORS   Ladd AN, Charlet N and Cooper TA.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   9  (residues 1 to 524)
  AUTHORS   Good PJ, Chen Q, Warner SJ and Herring DC.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
REFERENCE   10 (residues 1 to 524)
  AUTHORS   Yulug IG, Egan SE, See CG and Fisher EM.
  TITLE     Mapping GRB2, a signal transduction gene in the human and the mouse
  JOURNAL   Genomics 22 (2), 313-318 (1994)
   PUBMED   7806216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121094.8 and AC144938.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164131,
                              SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..524
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 13.92 cM"
     Protein         1..524
                     /product="CUGBP Elav-like family member 4 isoform 15"
                     /note="CUG-BP- and ETR-3-like factor 4; bruno-like protein
                     4; RNA-binding protein BRUNOL-4; bruno-like 4, RNA binding
                     protein"
                     /calculated_mol_wt=55752
     Region          49..135
                     /region_name="RRM1_CELF3_4_5_6"
                     /note="RNA recognition motif 1 (RRM1) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12632"
                     /db_xref="CDD:410041"
     Site            order(55,57,59..60,63,82,84,86,95..97,99,129,131)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410041"
     Region          140..220
                     /region_name="RRM2_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12635"
                     /db_xref="CDD:410043"
     Site            order(142,144,146..147,150,169,171,173,181..183,185,215,
                     217)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410043"
     Region          405..>433
                     /region_name="RRM_SF"
                     /note="RNA recognition motif (RRM) superfamily; cl17169"
                     /db_xref="CDD:450164"
     CDS             1..524
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /coded_by="NM_001362290.1:531..2105"
                     /note="isoform 15 is encoded by transcript variant 21"
                     /db_xref="GeneID:108013"
                     /db_xref="MGI:MGI:1932407"
ORIGIN      
        1 myikmatlan gqadnaslst nglgsspgsa ghmnglshsp gnpstipmkd hdaiklfigq
       61 iprnldekdl kplfeefgki yeltvlkdrf tgmhkgcafl tyceresalk aqsalheqkt
      121 lpgmnrpiqv kpadsesrgd rklfvgmlnk qqseddvrrl feafgnieec tilrgpdgns
      181 kgcafvkyss haeaqaaina lhgsqtmpga ssslvvkfad tdkertmrrm qqmagqmgmf
      241 npmaipfgay gayaqamqqq aalmasvaqg gylnpmaafa aaqmqqmaal nmnglaaapm
      301 tptsggstpp gitapavpsi pspigvngft glppqangqp aaeavfangi hpypaqspta
      361 adplqqayag vqqyagpaay paaygqisqa fpqpppmipq qqregpegcn lliyhlpqef
      421 gdaelmqmfl pfgrhpvpsr cqapscqggq caisssarrl relrqpgqrt drhpgherlp
      481 drheeaqgaa eaaqrrqspv lsaggsvprg rpglaqgrml nglh
//
LOCUS       NP_001390658             734 aa            linear   ROD 09-OCT-2023
DEFINITION  transcriptional repressor CTCF isoform 3 [Mus musculus].
ACCESSION   NP_001390658 XP_036009640
VERSION     NP_001390658.1
DBSOURCE    REFSEQ: accession NM_001403729.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 734)
  AUTHORS   Hewitt SC, Gruzdev A, Willson CJ, Wu SP, Lydon JP, Galjart N and
            DeMayo FJ.
  TITLE     Chromatin architectural factor CTCF is essential for
            progesterone-dependent uterine maturation
  JOURNAL   FASEB J 37 (8), e23103 (2023)
   PUBMED   37489832
  REMARK    GeneRIF: Chromatin architectural factor CTCF is essential for
            progesterone-dependent uterine maturation.
REFERENCE   2  (residues 1 to 734)
  AUTHORS   Smits WK, Vermeulen C, Hagelaar R, Kimura S, Vroegindeweij EM,
            Buijs-Gladdines JGCAM, van de Geer E, Verstegen MJAM, Splinter E,
            van Reijmersdal SV, Buijs A, Galjart N, van Eyndhoven W, van Min M,
            Kuiper R, Kemmeren P, Mullighan CG, de Laat W and Meijerink JPP.
  TITLE     Elevated enhancer-oncogene contacts and higher oncogene expression
            levels by recurrent CTCF inactivating mutations in acute T cell
            leukemia
  JOURNAL   Cell Rep 42 (4), 112373 (2023)
   PUBMED   37060567
REFERENCE   3  (residues 1 to 734)
  AUTHORS   Wang B, Ji L and Bian Q.
  TITLE     SATB1 regulates 3D genome architecture in T cells by constraining
            chromatin interactions surrounding CTCF-binding sites
  JOURNAL   Cell Rep 42 (4), 112323 (2023)
   PUBMED   37000624
  REMARK    GeneRIF: SATB1 regulates 3D genome architecture in T cells by
            constraining chromatin interactions surrounding CTCF-binding sites.
REFERENCE   4  (residues 1 to 734)
  AUTHORS   Marina-Zarate E, Rodriguez-Ronchel A, Gomez MJ, Sanchez-Cabo F and
            Ramiro AR.
  TITLE     Low-affinity CTCF binding drives transcriptional regulation whereas
            high-affinity binding encompasses architectural functions
  JOURNAL   iScience 26 (3), 106106 (2023)
   PUBMED   36852270
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 734)
  AUTHORS   Hsieh TS, Cattoglio C, Slobodyanyuk E, Hansen AS, Darzacq X and
            Tjian R.
  TITLE     Enhancer-promoter interactions and transcription are largely
            maintained upon acute loss of CTCF, cohesin, WAPL or YY1
  JOURNAL   Nat Genet 54 (12), 1919-1932 (2022)
   PUBMED   36471071
  REMARK    GeneRIF: Enhancer-promoter interactions and transcription are
            largely maintained upon acute loss of CTCF, cohesin, WAPL or YY1.
REFERENCE   6  (residues 1 to 734)
  AUTHORS   Farrell CM, West AG and Felsenfeld G.
  TITLE     Conserved CTCF insulator elements flank the mouse and human
            beta-globin loci
  JOURNAL   Mol Cell Biol 22 (11), 3820-3831 (2002)
   PUBMED   11997516
  REMARK    GeneRIF: Conserved CTCF insulator elements flank the mouse and
            human beta-globin loci.
REFERENCE   7  (residues 1 to 734)
  AUTHORS   Burke LJ, Hollemann T, Pieler T and Renkawitz R.
  TITLE     Molecular cloning and expression of the chromatin insulator protein
            CTCF in Xenopus laevis
  JOURNAL   Mech Dev 113 (1), 95-98 (2002)
   PUBMED   11900981
REFERENCE   8  (residues 1 to 734)
  AUTHORS   Chao W, Huynh KD, Spencer RJ, Davidow LS and Lee JT.
  TITLE     CTCF, a candidate trans-acting factor for X-inactivation choice
  JOURNAL   Science 295 (5553), 345-347 (2002)
   PUBMED   11743158
  REMARK    GeneRIF: It's proposed that Tsix and CTCF together establish a
            regulatable epigenetic switch for X-inactivation.
REFERENCE   9  (residues 1 to 734)
  AUTHORS   Lutz M, Burke LJ, Barreto G, Goeman F, Greb H, Arnold R,
            Schultheiss H, Brehm A, Kouzarides T, Lobanenkov V and Renkawitz R.
  TITLE     Transcriptional repression by the insulator protein CTCF involves
            histone deacetylases
  JOURNAL   Nucleic Acids Res 28 (8), 1707-1713 (2000)
   PUBMED   10734189
REFERENCE   10 (residues 1 to 734)
  AUTHORS   Filippova GN, Fagerlie S, Klenova EM, Myers C, Dehner Y, Goodwin G,
            Neiman PE, Collins SJ and Lobanenkov VV.
  TITLE     An exceptionally conserved transcriptional repressor, CTCF, employs
            different combinations of zinc fingers to bind diverged promoter
            sequences of avian and mammalian c-myc oncogenes
  JOURNAL   Mol Cell Biol 16 (6), 2802-2813 (1996)
   PUBMED   8649389
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127419.3 and AC152826.2.
            
            On Apr 4, 2022 this sequence version replaced XP_036009640.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422600.2077717.1,
                                           SRR13422590.461684.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..734
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.04 cM"
     Protein         1..734
                     /product="transcriptional repressor CTCF isoform 3"
                     /note="transcriptional repressor CTCF; CTCFL paralog;
                     11-zinc finger protein"
                     /calculated_mol_wt=83443
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          180..211
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61164.2)"
     Region          266..289
                     /region_name="zf-H2C2_5"
                     /note="C2H2-type zinc-finger domain; pfam13909"
                     /db_xref="CDD:404746"
     Region          268..288
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(273,275,277,279..280,283..284,287,301,303,307..308,
                     311..312,315,329,331,333,335..336,339..340,346)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          280..305
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:433230"
     Site            289
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          296..316
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          309..333
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:433230"
     Site            317
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          324..347
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          351..375
                     /region_name="zf-H2C2_5"
                     /note="C2H2-type zinc-finger domain; pfam13909"
                     /db_xref="CDD:404746"
     Region          353..373
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          <366..500
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Site            374
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          381..401
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            402
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          409..426
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          439..457
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          469..489
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(474,476,478,480..481,484..485,488,502,504,508..509,
                     512..513,516,530,532,534,536..537,540..541,545)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          497..517
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          509..534
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:433230"
     Region          525..546
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          557..573
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            609
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Site            610
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Site            612
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          697..724
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61164.2)"
     CDS             1..734
                     /gene="Ctcf"
                     /coded_by="NM_001403729.1:327..2531"
                     /note="isoform 3 is encoded by transcript variant 9"
                     /db_xref="GeneID:13018"
                     /db_xref="MGI:MGI:109447"
ORIGIN      
        1 megeaveaiv eesetfikgk erktyqrrre ggqeedachl pqnqtdggev vqdvnssvqm
       61 vmmeqldptl lqmktevmeg tvapeaeaav ddtqiitlqv vnmeeqpini gelqlvqvpv
      121 pvtvpvatts veelqgayen evskeglaes epmichtlpl pegfqvvkvg angevetleq
      181 gelppqedss wqkdpdyqpp akktkktkks klryteegkd vdvsvydfee eqqegllsev
      241 naekvvgnmk ppkptkikkk gvkktfqcel csytcprrsn ldrhmkshtd erphkchlcg
      301 rafrtvtllr nhlnthtgtr phkcpdcdma fvtsgelvrh rrykhthekp fkcsmcdyas
      361 vevsklkrhi rshtgerpfq cslcsyasrd tyklkrhmrt hsgekpyecy icharftqsg
      421 tmkmhilqkh tenvakfhcp hcdtviarks dlgvhlrkqh syieqgkkcr ycdavfhery
      481 aliqhqkshk nekrfkcdqc dyacrqerhm imhkrthtge kpyacshcdk tfrqkqlldm
      541 hfkryhdpnf vpaafvcskc gktftrrntm arhadncagp dgvegengge tkkskrgrkr
      601 kmrskkedss dseenaepdl ddneeeeepa veiepepepq pqpppppqpv apapppakkr
      661 rgrppgrtnq pkqnqpiiqv edqntgaien iivevkkepd aepaegeeee aqaattdapn
      721 gdltpemils mmdr
//
LOCUS       NP_001349210             535 aa            linear   ROD 09-OCT-2023
DEFINITION  CUGBP Elav-like family member 4 isoform 7 [Mus musculus].
ACCESSION   NP_001349210 XP_017173276
VERSION     NP_001349210.1
DBSOURCE    REFSEQ: accession NM_001362281.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 535)
  AUTHORS   Salamon I, Park Y, Miskic T, Kopic J, Matteson P, Page NF, Roque A,
            McAuliffe GW, Favate J, Garcia-Forn M, Shah P, Judas M, Millonig
            JH, Kostovic I, De Rubeis S, Hart RP, Krsnik Z and Rasin MR.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    GeneRIF: Celf4 controls mRNA translation underlying synaptic
            development in the prenatal mammalian neocortex.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 535)
  AUTHORS   Shen Y, Zhang C, Xiao K, Liu D and Xie G.
  TITLE     CELF4 regulates spine formation and depression-like behaviors of
            mice
  JOURNAL   Biochem Biophys Res Commun 605, 39-44 (2022)
   PUBMED   35306363
  REMARK    GeneRIF: CELF4 regulates spine formation and depression-like
            behaviors of mice.
REFERENCE   3  (residues 1 to 535)
  AUTHORS   Moreau MX, Saillour Y, Cwetsch AW, Pierani A and Causeret F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   4  (residues 1 to 535)
  AUTHORS   Li C, Li X, Bi Z, Sugino K, Wang G, Zhu T and Liu Z.
  TITLE     Comprehensive transcriptome analysis of cochlear spiral ganglion
            neurons at multiple ages
  JOURNAL   Elife 9, e50491 (2020)
   PUBMED   31913118
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 535)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 535)
  AUTHORS   Ladd AN, Taffet G, Hartley C, Kearney DL and Cooper TA.
  TITLE     Cardiac tissue-specific repression of CELF activity disrupts
            alternative splicing and causes cardiomyopathy
  JOURNAL   Mol Cell Biol 25 (14), 6267-6278 (2005)
   PUBMED   15988035
  REMARK    GeneRIF: CELF protein activity is required for normal alternative
            splicing in the heart in vivo and normal CELF-mediated alternative
            splicing regulation is in turn required for normal cardiac
            function.
REFERENCE   7  (residues 1 to 535)
  AUTHORS   Meins M, Schlickum S, Wilhelm C, Missbach J, Yadav S, Glaser B,
            Grzmil M, Burfeind P and Laccone F.
  TITLE     Identification and characterization of murine Brunol4, a new member
            of the elav/bruno family
  JOURNAL   Cytogenet Genome Res 97 (3-4), 254-260 (2002)
   PUBMED   12438720
  REMARK    GeneRIF: cloning and characterization
REFERENCE   8  (residues 1 to 535)
  AUTHORS   Ladd AN, Charlet N and Cooper TA.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   9  (residues 1 to 535)
  AUTHORS   Good PJ, Chen Q, Warner SJ and Herring DC.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
REFERENCE   10 (residues 1 to 535)
  AUTHORS   Yulug IG, Egan SE, See CG and Fisher EM.
  TITLE     Mapping GRB2, a signal transduction gene in the human and the mouse
  JOURNAL   Genomics 22 (2), 313-318 (1994)
   PUBMED   7806216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121094.8 and AC144938.3.
            
            On Apr 12, 2018 this sequence version replaced XP_017173276.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.266509.1,
                                           SRR7652917.792026.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..535
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 13.92 cM"
     Protein         1..535
                     /product="CUGBP Elav-like family member 4 isoform 7"
                     /note="CUG-BP- and ETR-3-like factor 4; bruno-like protein
                     4; RNA-binding protein BRUNOL-4; bruno-like 4, RNA binding
                     protein"
                     /calculated_mol_wt=56900
     Region          18..39
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          49..135
                     /region_name="RRM1_CELF3_4_5_6"
                     /note="RNA recognition motif 1 (RRM1) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12632"
                     /db_xref="CDD:410041"
     Site            order(55,57,59..60,63,82,84,86,95..97,99,129,131)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410041"
     Region          121..149
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          150..230
                     /region_name="RRM2_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12635"
                     /db_xref="CDD:410043"
     Site            order(152,154,156..157,160,179,181,183,191..193,195,225,
                     227)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410043"
     Region          238..257
                     /region_name="Necessary for TNNT2 exon 5 inclusion.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          416..>444
                     /region_name="RRM_SF"
                     /note="RNA recognition motif (RRM) superfamily; cl17169"
                     /db_xref="CDD:450164"
     CDS             1..535
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /coded_by="NM_001362281.1:531..2138"
                     /note="isoform 7 is encoded by transcript variant 13"
                     /db_xref="GeneID:108013"
                     /db_xref="MGI:MGI:1932407"
ORIGIN      
        1 myikmatlan gqadnaslst nglgsspgsa ghmnglshsp gnpstipmkd hdaiklfigq
       61 iprnldekdl kplfeefgki yeltvlkdrf tgmhkgcafl tyceresalk aqsalheqkt
      121 lpgmnrpiqv kpadsesrgg ssclrqppsh rklfvgmlnk qqseddvrrl feafgnieec
      181 tilrgpdgns kgcafvkyss haeaqaaina lhgsqtmpga ssslvvkfad tdkertmrrm
      241 qqmagqmgmf npmaipfgay gayaqalmqq qaalmasvaq ggylnpmaaf aaaqmqqmaa
      301 lnmnglaaap mtptsggstp pgitapavps ipspigvngf tglppqangq paaeavfang
      361 ihpypaqspt aadplqqaya gvqqyagpaa ypaaygqisq afpqpppmip qqqregpegc
      421 nlliyhlpqe fgdaelmqmf lpfgrhpvps rcqapscqgg qcaisssarr lrelrqpgqr
      481 tdrhpgherl pdrheeaqga aeaaqrrqsp vlsaggsvpr grpglaqgrm lnglh
//
LOCUS       NP_001263337            2386 aa            linear   ROD 09-OCT-2023
DEFINITION  fibronectin isoform b precursor [Mus musculus].
ACCESSION   NP_001263337
VERSION     NP_001263337.1
DBSOURCE    REFSEQ: accession NM_001276408.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 2386)
  AUTHORS   Huo X, Ma S, Wang C, Song L, Yao B, Zhu S, Li P, Wang L, Wu Z and
            Wang K.
  TITLE     Unravelling the role of immune cells and FN1 in the recurrence and
            therapeutic process of skull base chordoma
  JOURNAL   Clin Transl Med 13 (10), e1429 (2023)
   PUBMED   37784253
  REMARK    GeneRIF: Unravelling the role of immune cells and FN1 in the
            recurrence and therapeutic process of skull base chordoma.
REFERENCE   2  (residues 1 to 2386)
  AUTHORS   Whisler J, Shahreza S, Schlegelmilch K, Ege N, Javanmardi Y,
            Malandrino A, Agrawal A, Fantin A, Serwinski B, Azizgolshani H,
            Park C, Shone V, Demuren OO, Del Rosario A, Butty VL, Holroyd N,
            Domart MC, Hooper S, Szita N, Boyer LA, Walker-Samuel S, Djordjevic
            B, Sheridan GK, Collinson L, Calvo F, Ruhrberg C, Sahai E, Kamm R
            and Moeendarbary E.
  TITLE     Emergent mechanical control of vascular morphogenesis
  JOURNAL   Sci Adv 9 (32), eadg9781 (2023)
   PUBMED   37566656
REFERENCE   3  (residues 1 to 2386)
  AUTHORS   Jena SK, Das S, Chakraborty S and Ain R.
  TITLE     Molecular determinants of epithelial mesenchymal transition in
            mouse placenta and trophoblast stem cell
  JOURNAL   Sci Rep 13 (1), 10978 (2023)
   PUBMED   37414855
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 2386)
  AUTHORS   Hiver S, Shimizu-Mizuno N, Ikawa Y, Kajikawa E, Sai X, Nishimura H,
            Takaoka K, Nishimura O, Kuraku S, Tanaka S and Hamada H.
  TITLE     Gse1, a component of the CoREST complex, is required for placenta
            development in the mouse
  JOURNAL   Dev Biol 498, 97-105 (2023)
   PUBMED   37019373
REFERENCE   5  (residues 1 to 2386)
  AUTHORS   Ozguldez HO, Govindasamy N, Fan R, Long H, Mildner K, Zeuschner D,
            Trappmann B, Ranga A and Bedzhov I.
  TITLE     Polarity inversion reorganizes the stem cell compartment of the
            trophoblast lineage
  JOURNAL   Cell Rep 42 (4), 112313 (2023)
   PUBMED   36989113
REFERENCE   6  (residues 1 to 2386)
  AUTHORS   Saga Y, Yagi T, Ikawa Y, Sakakura T and Aizawa S.
  TITLE     Mice develop normally without tenascin
  JOURNAL   Genes Dev 6 (10), 1821-1831 (1992)
   PUBMED   1383086
REFERENCE   7  (residues 1 to 2386)
  AUTHORS   Khandjian EW, Salomon C, Leonard N, Tremblay S and Turler H.
  TITLE     Fibronectin gene expression in proliferating, quiescent, and
            SV40-infected mouse kidney cells
  JOURNAL   Exp Cell Res 202 (2), 464-470 (1992)
   PUBMED   1327855
REFERENCE   8  (residues 1 to 2386)
  AUTHORS   Vidal SM, Epstein DJ, Malo D, Weith A, Vekemans M and Gros P.
  TITLE     Identification and mapping of six microdissected genomic DNA probes
            to the proximal region of mouse chromosome 1
  JOURNAL   Genomics 14 (1), 32-37 (1992)
   PUBMED   1358796
REFERENCE   9  (residues 1 to 2386)
  AUTHORS   Malo D, Schurr E, Epstein DJ, Vekemans M, Skamene E and Gros P.
  TITLE     The host resistance locus Bcg is tightly linked to a group of
            cytoskeleton-associated protein genes that include villin and
            desmin
  JOURNAL   Genomics 10 (2), 356-364 (1991)
   PUBMED   1676979
REFERENCE   10 (residues 1 to 2386)
  AUTHORS   Wartiovaara,J., Leivo,I. and Vaheri,A.
  TITLE     Expression of the cell surface-associated glycoprotein,
            fibronectin, in the early mouse embryo
  JOURNAL   Dev Biol 69 (1), 247-257 (1979)
   PUBMED   376373
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ098561.1, CJ099024.1, CN534124.1, AK147683.1, AK147249.1 and
            AC124821.5.
            
            Transcript Variant: This variant (2) lacks an in-frame exon in the
            coding region, compared to variant 1. The encoded isoform (b) is
            shorter than isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147683.1, SRR17253014.449505.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2386
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 36.05 cM"
     Protein         1..2386
                     /product="fibronectin isoform b precursor"
                     /calculated_mol_wt=260064
     sig_peptide     1..27
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=2797
     Region          53..90
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain, approximately 40 residue
                     long with two conserved disulfide bridges. FN1 is one of
                     three types of internal repeats which combine to form
                     larger domains within fibronectin. Fibronectin, a plasma
                     protein that binds cell surfaces...; cd00061"
                     /db_xref="CDD:238018"
     Region          98..141
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          142..185
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          187..231
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          232..271
                     /region_name="fn1"
                     /note="Fibronectin type I domain; pfam00039"
                     /db_xref="CDD:425437"
     Region          308..347
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          353..401
                     /region_name="FN2"
                     /note="Fibronectin type 2 domain; smart00059"
                     /db_xref="CDD:128373"
     Site            order(364,366,371,385,392,398,400)
                     /site_type="active"
                     /note="putative gelatin-binding site [active]"
                     /db_xref="CDD:238019"
     Region          413..461
                     /region_name="FN2"
                     /note="Fibronectin type 2 domain; smart00059"
                     /db_xref="CDD:128373"
     Site            order(424,426,431,445,452,458,460)
                     /site_type="active"
                     /note="putative gelatin-binding site [active]"
                     /db_xref="CDD:238019"
     Region          470..513
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          518..560
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          561..604
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          619..688
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Region          726..797
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(797..798,800..801)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Site            order(810,871,886)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Region          811..882
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(887..888,890..891)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          907..987
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(984..985,987..988)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          997..1075
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(1073..1074,1076..1077)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1091..1158
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Region          1174..1257
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(1254..1255,1257..1258)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1267..1348
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Region          1358..1438
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Region          1450..1529
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(1525..1526,1528..1529)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1542..1622
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(1619..1620,1622..1623)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1632..1712
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Region          1722..1802
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(1799..1800,1802..1803)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1814..1893
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(1890..1891,1893..1894)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1903..1983
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Region          2119..2174
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Region          2205..2249
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          2250..2291
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          2293..2332
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain, approximately 40 residue
                     long with two conserved disulfide bridges. FN1 is one of
                     three types of internal repeats which combine to form
                     larger domains within fibronectin. Fibronectin, a plasma
                     protein that binds cell surfaces...; cd00061"
                     /db_xref="CDD:238018"
     CDS             1..2386
                     /gene="Fn1"
                     /gene_synonym="E330027I09; Fn; Fn-1"
                     /coded_by="NM_001276408.1:253..7413"
                     /note="isoform b precursor is encoded by transcript
                     variant 2"
                     /db_xref="CCDS:CCDS78612.1"
                     /db_xref="GeneID:14268"
                     /db_xref="MGI:MGI:95566"
ORIGIN      
        1 mlrgpgpgrl lllavlclgt svrcteagks krqaqqivqp qspvavsqsk pgcfdngkhy
       61 qinqqwerty lgnalvctcy ggsrgfnces kpepeetcfd kytgntykvg dtyerpkdsm
      121 iwdctcigag rgrisctian rcheggqsyk igdkwrrphe tggymleclc lgngkgewtc
      181 kpiaekcfdh aagtsyvvge twekpyqgwm mvdctclgeg ngritctsrn rcndqdtrts
      241 yrigdtwskk dnrgnllqcv ctgngrgewk cerhalqsas agsgsftdvr taiyqpqthp
      301 qpapyghcvt dsgvvysvgm qwlksqgnkq mlctclgngv scqetavtqt yggnsngepc
      361 vlpftyngrt fyscttegrq dghlwcstts nyeqdqkysf ctdhavlvqt rggnsngalc
      421 hfpflynnrn ytdctsegrr dnmkwcgttq nydadqkfgf cpmaaheeic ttnegvmyri
      481 gdqwdkqhdl ghmmrctcvg ngrgewacip ysqlrdqciv dditynvndt fhkrheeghm
      541 lnctcfgqgr grwkcdpidq cqdsetrtfy qigdswekfv hgvryqcycy grgigewhcq
      601 plqtypgttg pvqviitetp sqpnshpiqw napepshitk yilrwrpkts tgrwkeatip
      661 ghlnsytikg ltpgviyegq lisiqqyghr evtrfdftts astpvtsntv tgetapyspv
      721 vatsesvtei tassfvvswv sasdtvsgfr veyelseegd epqyldlpst atsvnipdll
      781 pgrkyivnvy qiseegkqsl ilstsqttap dappdptvdq vddtsivvrw srpqapitgy
      841 rivyspsveg sstelnlpet ansvtlsdlq pgvqynitiy aveenqestp vfiqqettgt
      901 prsdnvpppt dlqfveltdv kvtimwtppd svvsgyrvev lpvslpgehg qrlpvnrntf
      961 aeitglspgv tylfkvfavh qgresnplta qqttkldapt nlqfvnetdr tvlvtwtppr
     1021 ariagyrlta gltrggqpkq ynvgplasky plrnlqpgse ytvtlvavkg nqqspkatgv
     1081 fttlqplrsi ppyntevtet tivitwtpap rigfklgvrp sqggeaprev tsdsgsivvs
     1141 gltpgveyty tiqvlrdgqe rdapivnrvv tplspptnlh leanpdtgvl tvswersttp
     1201 ditgyrittt ptngqqgtsl eevvhadqss ctfenlnpgl eynvsvytvk ddkesapisd
     1261 tvvpavpppt dlrftnigpd tmrvtwappp sieltnllvr yspvkneedv aelsispsdn
     1321 avvltnllpg teylvsvssv yeqhesiplr grqktgldsp tgfdssdita nsftvhwvap
     1381 rapitgyiir hhaehsvgrp rqdrvppsrn sitltnlnpg teyvvsiiav ngreesppli
     1441 gqqatvsdip rdleviastp tslliswepp avsvryyrit ygetggnspv qeftvpgsks
     1501 tatinnikpg adytitlyav tgrgdspass kpvsinykte idkpsqmqvt dvqdnsisvr
     1561 wlpstspvtg yrvtttpkng lgpsktktas pdqtemtieg lqptveyvvs vyaqnrnges
     1621 qplvqtavtn idrpkglaft dvdvdsikia wespqgqvsr yrvtyssped girelfpapd
     1681 geddtaelqg lrpgseytvs vvalhddmes qpligiqsta ipaptnlkfs qvtptsftaq
     1741 wiapsvqltg yrvrvnpkek tgpmkeinls pdsssvivsg lmvatkyevs vyalkdtlts
     1801 rpaqgvittl envspprrar vtdatettit iswrtkteti tgfqvdaipa ngqtpvqrsi
     1861 spdvrsytit glqpgtdyki hlytlndnar sspviidast aidapsnlrf ltttpnsllv
     1921 swqaprarit gyiikyekpg spprevvprp rpgvteatit glepgteyti yvialknnqk
     1981 sepligrkkt delpqlvtlp hpnlhgpeil dvpstvqktp fitnpgydte ngiqlpgtth
     2041 qqpsvgqqmi feehgfrrtt pptaatpvrl rprpylpnvd eevqighvpr gdvdyhlyph
     2101 vpglnpnast gqealsqtti swtpfqesse yiiscqpvgt deeplqfqvp gtstsatltg
     2161 ltrgvtynii vealqnqrrh kvreevvtvg navseglnqp tddscfdpyt vshyaigeew
     2221 erlsdagfkl tcqclgfgsg hfrcdsskwc hdngvnykig ekwdrqgeng qrmsctclgn
     2281 gkgefkcdph eatcyddgkt yhvgeqwqke ylgaicsctc fggqrgwrcd ncrrpgaaep
     2341 spdgttghty nqytqrynqr tntnvncpie cfmpldvqad rddsre
//
LOCUS       NP_031984               1021 aa            linear   ROD 09-OCT-2023
DEFINITION  SWI/SNF-related matrix-associated actin-dependent regulator of
            chromatin subfamily A containing DEAD/H box 1 isoform 1 [Mus
            musculus].
ACCESSION   NP_031984 XP_132597
VERSION     NP_031984.1
DBSOURCE    REFSEQ: accession NM_007958.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1021)
  AUTHORS   Sachs P, Bergmaier P, Treutwein K and Mermoud JE.
  TITLE     The Conserved Chromatin Remodeler SMARCAD1 Interacts with TFIIIC
            and Architectural Proteins in Human and Mouse
  JOURNAL   Genes (Basel) 14 (9), 1793 (2023)
   PUBMED   37761933
  REMARK    GeneRIF: The Conserved Chromatin Remodeler SMARCAD1 Interacts with
            TFIIIC and Architectural Proteins in Human and Mouse.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1021)
  AUTHORS   Bedogni F and Hevner RF.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1021)
  AUTHORS   Niu Q, Wang W, Wei Z, Byeon B, Das AB, Chen BS and Wu WH.
  TITLE     Role of the ATP-dependent chromatin remodeling enzyme
            Fun30/Smarcad1 in the regulation of mRNA splicing
  JOURNAL   Biochem Biophys Res Commun 526 (2), 453-458 (2020)
   PUBMED   32234239
  REMARK    GeneRIF: Role of the ATP-dependent chromatin remodeling enzyme
            Fun30/Smarcad1 in the regulation of mRNA splicing.
REFERENCE   4  (residues 1 to 1021)
  AUTHORS   Kazakevych J, Denizot J, Liebert A, Portovedo M, Mosavie M, Jain P,
            Stellato C, Fraser C, Correa RO, Celestine M, Mattiuz R, Okkenhaug
            H, Miller JR, Vinolo MAR, Veldhoen M and Varga-Weisz P.
  TITLE     Smarcad1 mediates microbiota-induced inflammation in mouse and
            coordinates gene expression in the intestinal epithelium
  JOURNAL   Genome Biol 21 (1), 64 (2020)
   PUBMED   32160911
  REMARK    GeneRIF: Smarcad1 mediates microbiota-induced inflammation in mouse
            and coordinates gene expression in the intestinal epithelium.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1021)
  AUTHORS   Sachs P, Ding D, Bergmaier P, Lamp B, Schlagheck C, Finkernagel F,
            Nist A, Stiewe T and Mermoud JE.
  TITLE     SMARCAD1 ATPase activity is required to silence endogenous
            retroviruses in embryonic stem cells
  JOURNAL   Nat Commun 10 (1), 1335 (2019)
   PUBMED   30902974
  REMARK    GeneRIF: These findings uncover a role for the enzymatic activity
            of SMARCAD1 in cooperating with KAP1 to silence Endogenous
            retroviruses.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1021)
  AUTHORS   Ben-Arie N, McCall AE, Berkman S, Eichele G, Bellen HJ and Zoghbi
            HY.
  TITLE     Evolutionary conservation of sequence and expression of the bHLH
            protein Atonal suggests a conserved role in neurogenesis
  JOURNAL   Hum Mol Genet 5 (9), 1207-1216 (1996)
   PUBMED   8872459
REFERENCE   7  (residues 1 to 1021)
  AUTHORS   Villeneuve L, Jiang X, Turmel C, Kozak CA and Jolicoeur P.
  TITLE     Long-range mapping of Mis-2, a common provirus integration site
            identified in murine leukemia virus-induced thymomas and located
            160 kilobase pairs downstream of Myb
  JOURNAL   J Virol 67 (10), 5733-5739 (1993)
   PUBMED   8371338
REFERENCE   8  (residues 1 to 1021)
  AUTHORS   Schoor M, Schuster-Gossler K and Gossler A.
  TITLE     The Etl-1 gene encodes a nuclear protein differentially expressed
            during early mouse development
  JOURNAL   Dev Dyn 197 (3), 227-237 (1993)
   PUBMED   8219362
REFERENCE   9  (residues 1 to 1021)
  AUTHORS   Soininen R, Schoor M, Henseling U, Tepe C, Kisters-Woike B, Rossant
            J and Gossler A.
  TITLE     The mouse Enhancer trap locus 1 (Etl-1): a novel mammalian gene
            related to Drosophila and yeast transcriptional regulator genes
  JOURNAL   Mech Dev 39 (1-2), 111-123 (1992)
   PUBMED   1489724
REFERENCE   10 (residues 1 to 1021)
  AUTHORS   O'Kane CJ and Gehring WJ.
  TITLE     Detection in situ of genomic regulatory elements in Drosophila
  JOURNAL   Proc Natl Acad Sci U S A 84 (24), 9123-9127 (1987)
   PUBMED   2827169
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC138622.4 and AC143330.4.
            
            On May 17, 2005 this sequence version replaced XP_132597.3.
            
            Transcript Variant: This variant (1) encodes the longest protein
            (isoform 1).  Variants 1 and 5 encode the same protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK122454.1, X69942.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1021
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 30.11 cM"
     Protein         1..1021
                     /product="SWI/SNF-related matrix-associated
                     actin-dependent regulator of chromatin subfamily A
                     containing DEAD/H box 1 isoform 1"
                     /EC_number="3.6.4.12"
                     /note="enhancer trap locus homolog 1; ATP-dependent
                     helicase SMARCAD1; enhancer trap locus 1"
                     /calculated_mol_wt=116321
     Region          1..82
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q04692.2)"
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:Q9H4L7; propagated from
                     UniProtKB/Swiss-Prot (Q04692.2)"
     Site            54
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9H4L7; propagated from
                     UniProtKB/Swiss-Prot (Q04692.2)"
     Site            57
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H4L7; propagated from
                     UniProtKB/Swiss-Prot (Q04692.2)"
     Site            79
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H4L7; propagated from
                     UniProtKB/Swiss-Prot (Q04692.2)"
     Region          124..151
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q04692.2)"
     Site            124
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q04692.2)"
     Site            127
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q04692.2)"
     Site            132
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H4L7; propagated from
                     UniProtKB/Swiss-Prot (Q04692.2)"
     Site            144
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q04692.2)"
     Site            145
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q04692.2)"
     Site            151
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q04692.2)"
     Region          201..246
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q04692.2)"
     Site            210
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H4L7; propagated from
                     UniProtKB/Swiss-Prot (Q04692.2)"
     Site            213
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H4L7; propagated from
                     UniProtKB/Swiss-Prot (Q04692.2)"
     Site            235
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H4L7; propagated from
                     UniProtKB/Swiss-Prot (Q04692.2)"
     Site            238
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H4L7; propagated from
                     UniProtKB/Swiss-Prot (Q04692.2)"
     Site            298
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9H4L7; propagated from
                     UniProtKB/Swiss-Prot (Q04692.2)"
     Region          329..366
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q04692.2)"
     Region          471..>993
                     /region_name="PLN03142"
                     /note="Probable chromatin-remodeling complex ATPase chain;
                     Provisional"
                     /db_xref="CDD:215601"
     Region          492..674
                     /region_name="DEXHc_SMARCAD1"
                     /note="DEXH-box helicase domain of SMARCAD1; cd17998"
                     /db_xref="CDD:350756"
     Site            order(519..525,558,623..624)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:350756"
     Region          623..626
                     /region_name="DEGH box"
                     /note="propagated from UniProtKB/Swiss-Prot (Q04692.2)"
     Region          716..733
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q04692.2)"
     Region          1000..1003
                     /region_name="DEAD box"
                     /note="propagated from UniProtKB/Swiss-Prot (Q04692.2)"
     CDS             1..1021
                     /gene="Smarcad1"
                     /gene_synonym="D6Pas1; etl-1; Etl1; mKIAA1122"
                     /coded_by="NM_007958.3:192..3257"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS20204.1"
                     /db_xref="GeneID:13990"
                     /db_xref="MGI:MGI:95453"
ORIGIN      
        1 mnlfnldrfr fekrskieea peaapqpsqa rpsspislsa eeenaegegs rantpdsdvt
       61 ektedssvpe ppdnerkasl scfqnqraiq eyidlssdte dvspncsstv qekkfskdtv
      121 iivsepsede eshdlpsvtr rndsseledl seledlkdak lqtlkelfpq rsdsdllkli
      181 eststmdgai aaallmfgda gggprkrkls ssseeddvnd dqsvkqprgd rgeesnesae
      241 assnwekqes ivlklqkefp nfdkqelrev lkehewmyte aleslkvfae dqdvqcasqs
      301 evtngkevar nqnysknatk ikmkqkisvk pqngfnkkrk knvfnpkkav edseydsgsd
      361 agssldedys sceevmedgy kgkilhflqv ssiaeltlip kcsqkkaqki telrpfnnwe
      421 alftkmskin glsedliwnc ktviqerdvv irlmnkcedi snkltkqvtm ltgngggwnr
      481 eqpsllnqsl slkpyqkvgl nwlalvhkhg lngilademg lgktiqaiaf laylfqegnk
      541 gphlivvpas tidnwlrevn lwcpslnvlc yygsqeerkq irfnihnkye dynvivttyn
      601 caisssddrs lfrrlklnya ifdeghmlkn mgsiryqhlm tinarnrlll tgtpvqnnll
      661 elmsllnfvm phmfssstse irrmfssktk padeqsiyek eriahakqii kpfilrrvke
      721 evlkllppkk drielcamse kqeqlysglf nrlkksinnl ekntemcnvm mqlrkmanhp
      781 llhrqyytpe klkemsqlml kepthceanp dlifedmevm tdfelhvlck qyqhinsyql
      841 dmdlildsgk fralgcilse lkqkgdrvvl fsqftmmldi levllkhhqh rylrldgktq
      901 iserihlide fntdmdifvf llstkagglg inltsanvvi lhdidcnpyn dkqaedrchr
      961 vgqtkevlvi klisqgtiee smlkinqqkl kleqdmttvd eadegsmpad iatllktsmg
     1021 l
//
LOCUS       NP_035707                390 aa            linear   ROD 09-OCT-2023
DEFINITION  transforming growth factor beta-1 proprotein preproprotein [Mus
            musculus].
ACCESSION   NP_035707 XP_357724
VERSION     NP_035707.1
DBSOURCE    REFSEQ: accession NM_011577.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 390)
  AUTHORS   Riehl DR, Sharma A, Roewe J, Murke F, Ruppert C, Eming SA, Bopp T,
            Kleinert H, Radsak MP, Colucci G, Subramaniam S, Reinhardt C,
            Giebel B, Prinz I, Guenther A, Strand D, Gunzer M, Waisman A, Ward
            PA, Ruf W, Schafer K and Bosmann M.
  TITLE     Externalized histones fuel pulmonary fibrosis via a
            platelet-macrophage circuit of TGFbeta1 and IL-27
  JOURNAL   Proc Natl Acad Sci U S A 120 (40), e2215421120 (2023)
   PUBMED   37756334
  REMARK    GeneRIF: Externalized histones fuel pulmonary fibrosis via a
            platelet-macrophage circuit of TGFbeta1 and IL-27.
REFERENCE   2  (residues 1 to 390)
  AUTHORS   De Chiara L, Semeraro R, Mazzinghi B, Landini S, Molli A, Antonelli
            G, Angelotti ML, Melica ME, Maggi L, Conte C, Peired AJ, Cirillo L,
            Raglianti V, Magi A, Annunziato F, Romagnani P and Lazzeri E.
  TITLE     Polyploid tubular cells initiate a TGF-beta1 controlled loop that
            sustains polyploidization and fibrosis after acute kidney injury
  JOURNAL   Am J Physiol Cell Physiol 325 (4), C849-C861 (2023)
   PUBMED   37642236
  REMARK    GeneRIF: Polyploid tubular cells initiate a TGF-beta1 controlled
            loop that sustains polyploidization and fibrosis after acute kidney
            injury.
REFERENCE   3  (residues 1 to 390)
  AUTHORS   Cai X, Li M, Zhong Y, Yang W and Liang Z.
  TITLE     COMP Improves Ang-II-Induced Atrial Fibrillation via TGF-beta
            Signaling Pathway
  JOURNAL   Cardiovasc Toxicol 23 (9-10), 305-316 (2023)
   PUBMED   37584842
  REMARK    GeneRIF: COMP Improves Ang-II-Induced Atrial Fibrillation via
            TGF-beta Signaling Pathway.
REFERENCE   4  (residues 1 to 390)
  AUTHORS   Wang Y, Hong L, Jiang J, Zhang X, Chen J and Diao H.
  TITLE     Osteopontin May Improve Postinjury Muscle Repair Via Matrix
            Metalloproteinases And tgf-beta Activation in Regular Exercise
  JOURNAL   Int J Med Sci 20 (9), 1202-1211 (2023)
   PUBMED   37575268
  REMARK    GeneRIF: Osteopontin May Improve Postinjury Muscle Repair Via
            Matrix Metalloproteinases And tgf-beta Activation in Regular
            Exercise.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 390)
  AUTHORS   Kmiec P, Rosenkranz S, Odenthal M and Caglayan E.
  TITLE     Differential Role of Aldosterone and Transforming Growth Factor
            Beta-1 in Cardiac Remodeling
  JOURNAL   Int J Mol Sci 24 (15), 12237 (2023)
   PUBMED   37569619
  REMARK    GeneRIF: Differential Role of Aldosterone and Transforming Growth
            Factor Beta-1 in Cardiac Remodeling.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 390)
  AUTHORS   Ferguson MW, Sharpe PM, Thomas BL and Beck F.
  TITLE     Differential expression of insulin-like growth factors I and II
            (IGF I and II), mRNA, peptide and binding protein 1 during mouse
            palate development: comparison with TGF beta peptide distribution
  JOURNAL   J Anat 181 (Pt 2) (Pt 2), 219-238 (1992)
   PUBMED   1284245
REFERENCE   7  (residues 1 to 390)
  AUTHORS   Hannon K, Smith CK 2nd, Bales KR and Santerre RF.
  TITLE     Temporal and quantitative analysis of myogenic regulatory and
            growth factor gene expression in the developing mouse embryo
  JOURNAL   Dev Biol 151 (1), 137-144 (1992)
   PUBMED   1374351
REFERENCE   8  (residues 1 to 390)
  AUTHORS   Liu Y, Jones B, Aruffo A, Sullivan KM, Linsley PS and Janeway CA
            Jr.
  TITLE     Heat-stable antigen is a costimulatory molecule for CD4 T cell
            growth
  JOURNAL   J Exp Med 175 (2), 437-445 (1992)
   PUBMED   1346270
REFERENCE   9  (residues 1 to 390)
  AUTHORS   Manova K, Paynton BV and Bachvarova RF.
  TITLE     Expression of activins and TGF beta 1 and beta 2 RNAs in early
            postimplantation mouse embryos and uterine decidua
  JOURNAL   Mech Dev 36 (3), 141-152 (1992)
   PUBMED   1373953
REFERENCE   10 (residues 1 to 390)
  AUTHORS   de Larco,J.E. and Todaro,G.J.
  TITLE     Growth factors from murine sarcoma virus-transformed cells
  JOURNAL   Proc Natl Acad Sci U S A 75 (8), 4001-4005 (1978)
   PUBMED   211512
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC162614.2, AA510019.1,
            CK625059.1, AA821506.1 and BQ030974.1.
            
            On Dec 17, 2003 this sequence version replaced XP_357724.1.
            
            Summary: This gene encodes a secreted ligand of the TGF-beta
            (transforming growth factor-beta) superfamily of proteins. Ligands
            of this family bind various TGF-beta receptors leading to
            recruitment and activation of SMAD family transcription factors
            that regulate gene expression. The encoded preproprotein is
            proteolytically processed to generate a latency-associated peptide
            (LAP) and a mature peptide, and is found in either a latent form
            composed of a mature peptide homodimer, a LAP homodimer, and a
            latent TGF-beta binding protein, or in an active form consisting
            solely of the mature peptide homodimer. The mature peptide may also
            form heterodimers with other TGF-beta family members. This encoded
            protein regulates cell proliferation, differentiation and growth,
            and can modulate expression and activation of other growth factors
            including interferon gamma and tumor necrosis factor alpha. Mice
            lacking a functional copy of this gene develop severe multifocal
            inflammatory disease, yolk sac defects and colon cancer. [provided
            by RefSeq, Aug 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ009862.1, BC013738.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..390
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 13.98 cM"
     Protein         1..390
                     /product="transforming growth factor beta-1 proprotein
                     preproprotein"
                     /note="transforming growth factor beta-1 proprotein"
                     /calculated_mol_wt=41268
     sig_peptide     1..29
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=3060
     mat_peptide     30..278
                     /product="Latency-associated peptide.
                     /evidence=ECO:0000250|UniProtKB:P01137.
                     /id=PRO_0000033766"
                     /note="propagated from UniProtKB/Swiss-Prot (P04202.1)"
                     /calculated_mol_wt=28475
     Region          30..261
                     /region_name="TGFb_propeptide"
                     /note="TGF-beta propeptide; pfam00688"
                     /db_xref="CDD:425823"
     Region          30..74
                     /region_name="Straightjacket domain.
                     /evidence=ECO:0000250|UniProtKB:P07200"
                     /note="propagated from UniProtKB/Swiss-Prot (P04202.1)"
     Region          75..271
                     /region_name="Arm domain.
                     /evidence=ECO:0000250|UniProtKB:P07200"
                     /note="propagated from UniProtKB/Swiss-Prot (P04202.1)"
     Site            82
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P04202.1)"
     Site            136
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P04202.1)"
     Site            176
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P04202.1)"
     Region          226..252
                     /region_name="Bowtie tail.
                     /evidence=ECO:0000250|UniProtKB:P01137"
                     /note="propagated from UniProtKB/Swiss-Prot (P04202.1)"
     Region          244..246
                     /region_name="Cell attachment site. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (P04202.1)"
     Site            278..279
                     /site_type="cleavage"
                     /note="Cleavage, by FURIN.
                     /evidence=ECO:0000250|UniProtKB:P01137; propagated from
                     UniProtKB/Swiss-Prot (P04202.1)"
     mat_peptide     279..390
                     /product="Transforming growth factor beta-1.
                     /evidence=ECO:0000250|UniProtKB:P01137.
                     /id=PRO_0000033767"
                     /note="propagated from UniProtKB/Swiss-Prot (P04202.1)"
                     /calculated_mol_wt=12811
     Region          292..390
                     /region_name="TGF_beta_TGFB1"
                     /note="transforming growth factor beta (TGF-beta) like
                     domain found in transforming growth factor beta-1
                     (TGF-beta-1) and similar proteins; cd19384"
                     /db_xref="CDD:381654"
     Site            order(298..300,302,304..306,308,317,319..323,334..336,
                     338..340,342..343,346..347,351..353,355..358,361,379..384,
                     390)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:381654"
     CDS             1..390
                     /gene="Tgfb1"
                     /gene_synonym="TGF-beta1; Tgfb; Tgfb-1; TGFbeta1"
                     /coded_by="NM_011577.2:868..2040"
                     /db_xref="CCDS:CCDS20993.1"
                     /db_xref="GeneID:21803"
                     /db_xref="MGI:MGI:98725"
ORIGIN      
        1 mppsglrllp lllplpwllv ltpgrpaagl stcktidmel vkrkrieair gqilsklrla
       61 sppsqgevpp gplpeavlal ynstrdrvag esadpepepe adyyakevtr vlmvdrnnai
      121 yektkdishs iymffntsdi reavpeppll sraelrlqrl kssveqhvel yqkysnnswr
      181 ylgnrlltpt dtpewlsfdv tgvvrqwlnq gdgiqgfrfs ahcscdskdn klhveingis
      241 pkrrgdlgti hdmnrpflll matpleraqh lhssrhrral dtnycfsste knccvrqlyi
      301 dfrkdlgwkw ihepkgyhan fclgpcpyiw sldtqyskvl alynqhnpga saspccvpqa
      361 leplpivyyv grkpkveqls nmivrsckcs
//
LOCUS       NP_001298077             201 aa            linear   ROD 09-OCT-2023
DEFINITION  serine/threonine-protein kinase Nek7 isoform 2 [Mus musculus].
ACCESSION   NP_001298077 XP_006529833
VERSION     NP_001298077.1
DBSOURCE    REFSEQ: accession NM_001311148.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 201)
  AUTHORS   Park YJ, Dodantenna N, Kim Y, Kim TH, Lee HS, Yoo YS, Heo J, Lee
            JH, Kwon MH, Kang HC, Lee JS and Cho H.
  TITLE     MARCH5-dependent NLRP3 ubiquitination is required for mitochondrial
            NLRP3-NEK7 complex formation and NLRP3 inflammasome activation
  JOURNAL   EMBO J 42 (19), e113481 (2023)
   PUBMED   37575012
  REMARK    GeneRIF: MARCH5-dependent NLRP3 ubiquitination is required for
            mitochondrial NLRP3-NEK7 complex formation and NLRP3 inflammasome
            activation.
REFERENCE   2  (residues 1 to 201)
  AUTHORS   Sun W, Yue M, Xi G, Wang K and Sai J.
  TITLE     Knockdown of NEK7 alleviates anterior cruciate ligament transection
            osteoarthritis (ACLT)-induced knee osteoarthritis in mice via
            inhibiting NLRP3 activation
  JOURNAL   Autoimmunity 55 (6), 398-407 (2022)
   PUBMED   35798413
  REMARK    GeneRIF: Knockdown of NEK7 alleviates anterior cruciate ligament
            transection osteoarthritis (ACLT)-induced knee osteoarthritis in
            mice via inhibiting NLRP3 activation.
REFERENCE   3  (residues 1 to 201)
  AUTHORS   Zhang M, Zhi D, Lin J, Liu P, Wang Y and Duan M.
  TITLE     miR-181a-5p Inhibits Pyroptosis in Sepsis-Induced Acute Kidney
            Injury through Downregulation of NEK7
  JOURNAL   J Immunol Res 2022, 1825490 (2022)
   PUBMED   35991122
  REMARK    GeneRIF: miR-181a-5p Inhibits Pyroptosis in Sepsis-Induced Acute
            Kidney Injury through Downregulation of NEK7.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 201)
  AUTHORS   Wu G, Zhang D, Yang L, Wu Q and Yuan L.
  TITLE     MicroRNA-200c-5p targets NIMA Related Kinase 7 (NEK7) to inhibit
            NOD-like receptor 3 (NLRP3) inflammasome activation, MODE-K cell
            pyroptosis, and inflammatory bowel disease in mice
  JOURNAL   Mol Immunol 146, 57-68 (2022)
   PUBMED   35447415
  REMARK    GeneRIF: MicroRNA-200c-5p targets NIMA Related Kinase 7 (NEK7) to
            inhibit NOD-like receptor 3 (NLRP3) inflammasome activation, MODE-K
            cell pyroptosis, and inflammatory bowel disease in mice.
REFERENCE   5  (residues 1 to 201)
  AUTHORS   Jeltema D, Wang J, Cai J, Kelley N, Yang Z and He Y.
  TITLE     A Single Amino Acid Residue Defines the Difference in NLRP3
            Inflammasome Activation between NEK7 and NEK6
  JOURNAL   J Immunol 208 (8), 2029-2036 (2022)
   PUBMED   35354613
  REMARK    GeneRIF: A Single Amino Acid Residue Defines the Difference in
            NLRP3 Inflammasome Activation between NEK7 and NEK6.
REFERENCE   6  (residues 1 to 201)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (residues 1 to 201)
  AUTHORS   Morrish TA, Gilbert N, Myers JS, Vincent BJ, Stamato TD, Taccioli
            GE, Batzer MA and Moran JV.
  TITLE     DNA repair mediated by endonuclease-independent LINE-1
            retrotransposition
  JOURNAL   Nat Genet 31 (2), 159-165 (2002)
   PUBMED   12006980
REFERENCE   8  (residues 1 to 201)
  AUTHORS   Feige E and Motro B.
  TITLE     The related murine kinases, Nek6 and Nek7, display distinct
            patterns of expression
  JOURNAL   Mech Dev 110 (1-2), 219-223 (2002)
   PUBMED   11744387
  REMARK    GeneRIF: During early embryogenesis nek7 is expressed in the site
            of decidual reaction. Later in embryogenesis, nek7 is highly
            expressed in the dorsal thalamus.
REFERENCE   9  (residues 1 to 201)
  AUTHORS   Kimura M and Okano Y.
  TITLE     Identification and assignment of the human NIMA-related protein
            kinase 7 gene (NEK7) to human chromosome 1q31.3
  JOURNAL   Cytogenet Cell Genet 94 (1-2), 33-38 (2001)
   PUBMED   11701951
REFERENCE   10 (residues 1 to 201)
  AUTHORS   Kandli M, Feige E, Chen A, Kilfin G and Motro B.
  TITLE     Isolation and characterization of two evolutionarily conserved
            murine kinases (Nek6 and nek7) related to the fungal mitotic
            regulator, NIMA
  JOURNAL   Genomics 68 (2), 187-196 (2000)
   PUBMED   10964517
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC118216.15 and AC161436.4.
            
            On Jul 24, 2015 this sequence version replaced XP_006529833.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK165583.1, SRR7652917.642804.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164140
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..201
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 60.82 cM"
     Protein         1..201
                     /product="serine/threonine-protein kinase Nek7 isoform 2"
                     /EC_number="2.7.11.34"
                     /note="NIMA-related kinase 7; serine/threonine-protein
                     kinase Nek7; nimA-related protein kinase 7; never in
                     mitosis A-related kinase 7; NIMA-related expressed kinase
                     7"
                     /calculated_mol_wt=22592
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:Q8TDX7; propagated from
                     UniProtKB/Swiss-Prot (Q9ES74.1)"
     Site            5
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8TDX7; propagated from
                     UniProtKB/Swiss-Prot (Q9ES74.1)"
     Region          9..>199
                     /region_name="PKc_like"
                     /note="Protein Kinases, catalytic domain; cl21453"
                     /db_xref="CDD:451246"
     Region          20..33
                     /region_name="NTE motif.
                     /evidence=ECO:0000250|UniProtKB:Q8TDX7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ES74.1)"
     Site            order(40..43,46,48,61,63,95,111..114,161,165..166,168,
                     178..179)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270870"
     Site            97
                     /site_type="other"
                     /note="Autoinhibitory.
                     /evidence=ECO:0000250|UniProtKB:Q8TDX7; propagated from
                     UniProtKB/Swiss-Prot (Q9ES74.1)"
     Site            195
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by NEK9.
                     /evidence=ECO:0000250|UniProtKB:Q8TDX7; propagated from
                     UniProtKB/Swiss-Prot (Q9ES74.1)"
     CDS             1..201
                     /gene="Nek7"
                     /gene_synonym="2810460C19Rik"
                     /coded_by="NM_001311148.2:219..824"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS78695.1"
                     /db_xref="GeneID:59125"
                     /db_xref="MGI:MGI:1890645"
ORIGIN      
        1 mdeqsqgmqg ppvtqfqpqk alrpdmgynt lanfriekki grgqfsevyr asclldgvpv
       61 alkkvqifdl mdakaradci keidllkqln hpnvikyyas fiednelniv leladagdls
      121 rmikhfkkqk rlipertvwk yfvqlcsald hmhsrrvmhr dikpanvfit atgvvklgdl
      181 glgrffsskt taahslatta s
//
LOCUS       NP_001351566             385 aa            linear   ROD 09-OCT-2023
DEFINITION  RNA-binding protein Nova-1 isoform 4 [Mus musculus].
ACCESSION   NP_001351566
VERSION     NP_001351566.1
DBSOURCE    REFSEQ: accession NM_001364637.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 385)
  AUTHORS   Tajima Y, Ito K, Yuan Y, Frank MO, Saito Y and Darnell RB.
  TITLE     NOVA1 acts on Impact to regulate hypothalamic function and
            translation in inhibitory neurons
  JOURNAL   Cell Rep 42 (2), 112050 (2023)
   PUBMED   36716149
  REMARK    GeneRIF: NOVA1 acts on Impact to regulate hypothalamic function and
            translation in inhibitory neurons.
REFERENCE   2  (residues 1 to 385)
  AUTHORS   Brahma MK, Xiao P, Popa M, Negueruela J, Vandenbempt V, Demine S,
            Cardozo AK and Gurzov EN.
  TITLE     Nova1 or Bim Deficiency in Pancreatic beta-Cells Does Not Alter
            Multiple Low-Dose Streptozotocin-Induced Diabetes and Diet-Induced
            Obesity in Mice
  JOURNAL   Nutrients 14 (18), 3866 (2022)
   PUBMED   36145242
  REMARK    GeneRIF: Nova1 or Bim Deficiency in Pancreatic beta-Cells Does Not
            Alter Multiple Low-Dose Streptozotocin-Induced Diabetes and
            Diet-Induced Obesity in Mice.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 385)
  AUTHORS   Krach F, Wheeler EC, Regensburger M, Boerstler T, Wend H, Vu AQ,
            Wang R, Reischl S, Boldt K, Batra R, Aigner S, Ravits J, Winkler J,
            Yeo GW and Winner B.
  TITLE     Aberrant NOVA1 function disrupts alternative splicing in early
            stages of amyotrophic lateral sclerosis
  JOURNAL   Acta Neuropathol 144 (3), 413-435 (2022)
   PUBMED   35778567
  REMARK    GeneRIF: Aberrant NOVA1 function disrupts alternative splicing in
            early stages of amyotrophic lateral sclerosis.
REFERENCE   4  (residues 1 to 385)
  AUTHORS   Li D, Shen M, Deng X and Bai Y.
  TITLE     MicroRNA miR-27a-3p accelerates cardiac hypertrophy by targeting
            neuro-oncological ventral antigen 1
  JOURNAL   Bioengineered 13 (4), 8982-8993 (2022)
   PUBMED   35348441
  REMARK    GeneRIF: MicroRNA miR-27a-3p accelerates cardiac hypertrophy by
            targeting neuro-oncological ventral antigen 1.
REFERENCE   5  (residues 1 to 385)
  AUTHORS   Johnson V, Junge HJ and Chen Z.
  TITLE     Temporal regulation of axonal repulsion by alternative splicing of
            a conserved microexon in mammalian Robo1 and Robo2
  JOURNAL   Elife 8, e46042 (2019)
   PUBMED   31392959
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 385)
  AUTHORS   Jensen KB, Dredge BK, Stefani G, Zhong R, Buckanovich RJ, Okano HJ,
            Yang YY and Darnell RB.
  TITLE     Nova-1 regulates neuron-specific alternative splicing and is
            essential for neuronal viability
  JOURNAL   Neuron 25 (2), 359-371 (2000)
   PUBMED   10719891
REFERENCE   7  (residues 1 to 385)
  AUTHORS   Yang YY, Yin GL and Darnell RB.
  TITLE     The neuronal RNA-binding protein Nova-2 is implicated as the
            autoantigen targeted in POMA patients with dementia
  JOURNAL   Proc Natl Acad Sci U S A 95 (22), 13254-13259 (1998)
   PUBMED   9789075
REFERENCE   8  (residues 1 to 385)
  AUTHORS   Fletcher CF, Okano HJ, Gilbert DJ, Yang Y, Yang C, Copeland NG,
            Jenkins NA and Darnell RB.
  TITLE     Mouse chromosomal locations of nine genes encoding homologs of
            human paraneoplastic neurologic disorder antigens
  JOURNAL   Genomics 45 (2), 313-319 (1997)
   PUBMED   9344654
REFERENCE   9  (residues 1 to 385)
  AUTHORS   Buckanovich RJ and Darnell RB.
  TITLE     The neuronal RNA binding protein Nova-1 recognizes specific RNA
            targets in vitro and in vivo
  JOURNAL   Mol Cell Biol 17 (6), 3194-3201 (1997)
   PUBMED   9154818
REFERENCE   10 (residues 1 to 385)
  AUTHORS   Buckanovich RJ, Yang YY and Darnell RB.
  TITLE     The onconeural antigen Nova-1 is a neuron-specific RNA-binding
            protein, the activity of which is inhibited by paraneoplastic
            antibodies
  JOURNAL   J Neurosci 16 (3), 1114-1122 (1996)
   PUBMED   8558240
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156636.2, AC108802.15 and CT009504.11.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660821.10381.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..385
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 21.46 cM"
     Protein         1..385
                     /product="RNA-binding protein Nova-1 isoform 4"
                     /note="RNA-binding protein Nova-1; ventral neuron-specific
                     protein 1; neuro-oncological ventral antigen 1"
                     /calculated_mol_wt=38594
     Region          50..119
                     /region_name="KH-I_NOVA_rpt2"
                     /note="second type I K homology (KH) RNA-binding domain
                     found in the family of neuro-oncological ventral antigen
                     (Nova); cd22436"
                     /db_xref="CDD:411864"
     Site            order(61..63,65..69,72..73,83..85,87..89,97)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:411864"
     Region          300..370
                     /region_name="KH-I_NOVA_rpt3"
                     /note="third type I K homology (KH) RNA-binding domain
                     found in the family of neuro-oncological ventral antigen
                     (Nova); cd09031"
                     /db_xref="CDD:411807"
     Site            order(308..309,311..313,315..319,322..323,333..339,341,
                     346,348)
                     /site_type="other"
                     /note="RNA binding site [nucleotide binding]"
                     /db_xref="CDD:411807"
     CDS             1..385
                     /gene="Nova1"
                     /gene_synonym="9430099M15Rik; G630039L02; Nova-1"
                     /coded_by="NM_001364637.1:633..1790"
                     /note="isoform 4 is encoded by transcript variant 5"
                     /db_xref="GeneID:664883"
                     /db_xref="MGI:MGI:104297"
ORIGIN      
        1 mpqnvaktep vsilqpqttv npdrikqtlp ssptttkssp sdpmttsran qvkiivpnst
       61 agliigkgga tvkaimeqsg awvqlsqkpd ginlqervvt vsgepeqnrk aveliiqkiq
      121 edpqsgscln isyanvtgpv ansnptgspy antaevlpta aaaagllgha nlagvaafpa
      181 vlsgftgndl vaitsalntl asygynlntl glglsqaaat galaaaaasa npaaaaanll
      241 atyaseasas gstaggtagt falgslaaat aatngyfgaa splaasailg tekstdgskd
      301 vveiavpenl vgailgkggk tlveyqeltg ariqiskkge fvpgtrnrkv titgtpaatq
      361 aaqylitqri tyeqgvraan pqkvg
//
LOCUS       NP_705809                278 aa            linear   ROD 09-OCT-2023
DEFINITION  neuronal membrane glycoprotein M6-a isoform 1 [Mus musculus].
ACCESSION   NP_705809
VERSION     NP_705809.1
DBSOURCE    REFSEQ: accession NM_153581.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 278)
  AUTHORS   Li L, Sun Y, Davis AE, Shah SH, Hamed LK, Wu MR, Lin CH, Ding JB
            and Wang S.
  TITLE     Mettl14-mediated m6A modification ensures the cell-cycle
            progression of late-born retinal progenitor cells
  JOURNAL   Cell Rep 42 (6), 112596 (2023)
   PUBMED   37269288
  REMARK    GeneRIF: Mettl14-mediated m[6]A modification ensures the cell-cycle
            progression of late-born retinal progenitor cells.
REFERENCE   2  (residues 1 to 278)
  AUTHORS   Xie W, Zhang A, Huang X, Zhou H, Ying H, Ye C, Ren M, Qian M, Liu X
            and Mo Y.
  TITLE     SILENCING M 6 A READER YTHDC1 REDUCES INFLAMMATORY RESPONSE IN
            SEPSIS-INDUCED CARDIOMYOPATHY BY INHIBITING SERPINA3N EXPRESSION
  JOURNAL   Shock 59 (5), 791-802 (2023)
   PUBMED   36877222
  REMARK    GeneRIF: SILENCING M 6 A READER YTHDC1 REDUCES INFLAMMATORY
            RESPONSE IN SEPSIS-INDUCED CARDIOMYOPATHY BY INHIBITING SERPINA3N
            EXPRESSION.
REFERENCE   3  (residues 1 to 278)
  AUTHORS   Xue A, Huang Y, Li M, Wei Q and Bu Q.
  TITLE     Comprehensive Analysis of Differential m6A RNA Methylomes in the
            Hippocampus of Cocaine-Conditioned Mice
  JOURNAL   Mol Neurobiol 58 (8), 3759-3768 (2021)
   PUBMED   33826069
  REMARK    GeneRIF: Comprehensive Analysis of Differential m6A RNA Methylomes
            in the Hippocampus of Cocaine-Conditioned Mice.
REFERENCE   4  (residues 1 to 278)
  AUTHORS   Bedogni F and Hevner RF.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 278)
  AUTHORS   Ogawa T, Li Y, Lua I, Hartner A and Asahina K.
  TITLE     Isolation of a unique hepatic stellate cell population expressing
            integrin alpha8 from embryonic mouse livers
  JOURNAL   Dev Dyn 247 (6), 867-881 (2018)
   PUBMED   29665133
REFERENCE   6  (residues 1 to 278)
  AUTHORS   Yan Y, Narayanan V and Lagenaur C.
  TITLE     Expression of members of the proteolipid protein gene family in the
            developing murine central nervous system
  JOURNAL   J Comp Neurol 370 (4), 465-478 (1996)
   PUBMED   8807448
REFERENCE   7  (residues 1 to 278)
  AUTHORS   Olinsky S, Loop BT, DeKosky A, Ripepi B, Weng W, Cummins J, Wenger
            SL, Yan Y, Lagenaur C and Narayanan V.
  TITLE     Chromosomal mapping of the human M6 genes
  JOURNAL   Genomics 33 (3), 532-536 (1996)
   PUBMED   8661015
REFERENCE   8  (residues 1 to 278)
  AUTHORS   Shimizu F, Watanabe TK, Fujiwara T, Takahashi E, Nakamura Y and
            Maekawa H.
  TITLE     Isolation and mapping of the human glycoprotein M6 gene (GPM6A) to
            4q33-->q34
  JOURNAL   Cytogenet Cell Genet 74 (1-2), 138-139 (1996)
   PUBMED   8893821
REFERENCE   9  (residues 1 to 278)
  AUTHORS   Yan Y, Lagenaur C and Narayanan V.
  TITLE     Molecular cloning of M6: identification of a PLP/DM20 gene family
  JOURNAL   Neuron 11 (3), 423-431 (1993)
   PUBMED   8398137
REFERENCE   10 (residues 1 to 278)
  AUTHORS   Baumrind NL, Parkinson D, Wayne DB, Heuser JE and Pearlman AL.
  TITLE     EMA: a developmentally regulated cell-surface glycoprotein of CNS
            neurons that is concentrated at the leading edge of growth cones
  JOURNAL   Dev Dyn 194 (4), 311-325 (1992)
   PUBMED   1286213
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY247392.1, AK081877.1 and BC033357.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and it encodes the longest protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660819.29214.1,
                                           SRR1660817.260648.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..278
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 29.33 cM"
     Protein         1..278
                     /product="neuronal membrane glycoprotein M6-a isoform 1"
                     /note="neuronal membrane glycoprotein M6-a"
                     /calculated_mol_wt=31018
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:P51674; propagated from
                     UniProtKB/Swiss-Prot (P35802.1)"
     Region          15..247
                     /region_name="Myelin_PLP"
                     /note="Myelin proteolipid protein (PLP or lipophilin);
                     pfam01275"
                     /db_xref="CDD:426173"
     Site            23..43
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P35802.1)"
     Site            85..105
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P35802.1)"
     Site            128..148
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P35802.1)"
     Site            164
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P35802.1)"
     Site            208
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P35802.1)"
     Site            214..234
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P35802.1)"
     Site            256
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P35802.1)"
     Site            278
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q812E9; propagated from
                     UniProtKB/Swiss-Prot (P35802.1)"
     CDS             1..278
                     /gene="Gpm6a"
                     /gene_synonym="Gpm6; M6A"
                     /coded_by="NM_153581.6:552..1388"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS22310.1"
                     /db_xref="GeneID:234267"
                     /db_xref="MGI:MGI:107671"
ORIGIN      
        1 meenmeegqt qkgcfeccik clggipyasl iatillyagv alfcgcghea lsgtvnilqt
       61 yfelartagd tldvftmidi fkyviygiaa affvygillm vegffttgai kdlygdfkit
      121 tcgrcvsawf imltylfmla wlgvtaftsl pvymyfnvwt icrnttlveg anlcldlrqf
      181 givtigeekk ictasenflr mcestelnmt fhlfivalag agaaviamvh ylmvlsanwa
      241 yvkdacrmqk yedikskeeq elhdihstrs kerlnayt
//
LOCUS       NP_001405796             188 aa            linear   ROD 09-OCT-2023
DEFINITION  DDRGK domain-containing protein 1 isoform c [Mus musculus].
ACCESSION   NP_001405796
VERSION     NP_001405796.1
DBSOURCE    REFSEQ: accession NM_001418867.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 188)
  AUTHORS   Yang X, Zhou T, Wang X, Xia Y, Cao X, Cheng X, Cao Y, Ma P, Ma H,
            Qin A and Zhao J.
  TITLE     Loss of DDRGK1 impairs IRE1alpha UFMylation in spondyloepiphyseal
            dysplasia
  JOURNAL   Int J Biol Sci 19 (15), 4709-4725 (2023)
   PUBMED   37781516
  REMARK    GeneRIF: Loss of DDRGK1 impairs IRE1alpha UFMylation in
            spondyloepiphyseal dysplasia.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 188)
  AUTHORS   Tandra V, Anderson T, Ayala JD, Weintraub NL, Singh N, Li H and Li
            J.
  TITLE     Ufmylation of UFBP1 Is Dispensable for Endoplasmic Reticulum Stress
            Response, Embryonic Development, and Cardiac and Intestinal
            Homeostasis
  JOURNAL   Cells 12 (15), 1923 (2023)
   PUBMED   37566002
  REMARK    GeneRIF: Ufmylation of UFBP1 Is Dispensable for Endoplasmic
            Reticulum Stress Response, Embryonic Development, and Cardiac and
            Intestinal Homeostasis.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 188)
  AUTHORS   Chen F, Sheng L, Zhou T, Yan L, Loveless R, Li H, Teng Y and Cai Y.
  TITLE     Loss of Ufl1/Ufbp1 in hepatocytes promotes liver pathological
            damage and carcinogenesis through activating mTOR signaling
  JOURNAL   J Exp Clin Cancer Res 42 (1), 110 (2023)
   PUBMED   37131258
  REMARK    GeneRIF: Loss of Ufl1/Ufbp1 in hepatocytes promotes liver
            pathological damage and carcinogenesis through activating mTOR
            signaling.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 188)
  AUTHORS   Li H, Yu Z, Niu Z, Cheng Y, Wei Z, Cai Y, Ma F, Hu L, Zhu J and
            Zhang W.
  TITLE     A neuroprotective role of Ufmylation through Atg9 in the aging
            brain of Drosophila
  JOURNAL   Cell Mol Life Sci 80 (5), 129 (2023)
   PUBMED   37086384
  REMARK    GeneRIF: A neuroprotective role of Ufmylation through Atg9 in the
            aging brain of Drosophila.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 188)
  AUTHORS   Weisz-Hubshman M, Egunsula AT, Dawson B, Castellon A, Jiang MM,
            Chen-Evenson Y, Zhiyin Y, Lee B and Bae Y.
  TITLE     DDRGK1 is required for the proper development and maintenance of
            the growth plate cartilage
  JOURNAL   Hum Mol Genet 31 (16), 2820-2830 (2022)
   PUBMED   35377455
REFERENCE   6  (residues 1 to 188)
  AUTHORS   Yoo HM, Kang SH, Kim JY, Lee JE, Seong MW, Lee SW, Ka SH, Sou YS,
            Komatsu M, Tanaka K, Lee ST, Noh DY, Baek SH, Jeon YJ and Chung CH.
  TITLE     Modification of ASC1 by UFM1 is crucial for ERalpha transactivation
            and breast cancer development
  JOURNAL   Mol Cell 56 (2), 261-274 (2014)
   PUBMED   25219498
REFERENCE   7  (residues 1 to 188)
  AUTHORS   Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H,
            Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T,
            Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P,
            Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ,
            Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD,
            Flicek P, Skarnes WC, Mallon AM and Parkinson H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (residues 1 to 188)
  AUTHORS   Lemaire K, Moura RF, Granvik M, Igoillo-Esteve M, Hohmeier HE,
            Hendrickx N, Newgard CB, Waelkens E, Cnop M and Schuit F.
  TITLE     Ubiquitin fold modifier 1 (UFM1) and its target UFBP1 protect
            pancreatic beta cells from ER stress-induced apoptosis
  JOURNAL   PLoS One 6 (4), e18517 (2011)
   PUBMED   21494687
  REMARK    GeneRIF: These data suggest that UFM1-UFBP1 participate in
            preventing endoplasmic reticulum stress-induced apoptosis in
            protein secretory cells.
            Publication Status: Online-Only
REFERENCE   9  (residues 1 to 188)
  AUTHORS   Wu J, Lei G, Mei M, Tang Y and Li H.
  TITLE     A novel C53/LZAP-interacting protein regulates stability of
            C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and
            modulates NF-kappaB signaling
  JOURNAL   J Biol Chem 285 (20), 15126-15136 (2010)
   PUBMED   20228063
REFERENCE   10 (residues 1 to 188)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL772162.4 and AL731707.12.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422591.80764.1,
                                           SRR17253011.3542433.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..188
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 63.24 cM"
     Protein         1..188
                     /product="DDRGK domain-containing protein 1 isoform c"
                     /note="DDRGK domain-containing protein 1; UFM1-binding
                     protein 1 containing a PCI domain; UFM1-binding and PCI
                     domain-containing protein 1"
                     /calculated_mol_wt=21947
     Region          20..177
                     /region_name="DDRGK"
                     /note="DDRGK domain; pfam09756"
                     /db_xref="CDD:370664"
     CDS             1..188
                     /gene="Ddrgk1"
                     /gene_synonym="1110001I20Rik; 2600009E05Rik; Ufbp1"
                     /coded_by="NM_001418867.1:296..862"
                     /note="isoform c is encoded by transcript variant 4"
                     /db_xref="GeneID:77006"
                     /db_xref="MGI:MGI:1924256"
ORIGIN      
        1 mrmwvkllfq aeeaereerk rlesqreaew kkeeerlrlk eeqkeeeerk aqeeqarreh
       61 eeylklkeaf vveeegvset mteeqshsfl tefinyikks kvvlledlaf qmglrtqdai
      121 nriqdllteg tltgviddrg kfiyitpeel aavanfirqr grvsitelaq asnsliswgq
      181 dlpaqasa
//
LOCUS       NP_035934                220 aa            linear   ROD 09-OCT-2023
DEFINITION  protein CREG1 precursor [Mus musculus].
ACCESSION   NP_035934 XP_358337
VERSION     NP_035934.1
DBSOURCE    REFSEQ: accession NM_011804.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 220)
  AUTHORS   Zeng S, Du L, Lu G and Xing Y.
  TITLE     CREG Protects Retinal Ganglion Cells loss and Retinal Function
            Impairment Against ischemia-reperfusion Injury in mice via Akt
            Signaling Pathway
  JOURNAL   Mol Neurobiol 60 (10), 6018-6028 (2023)
   PUBMED   37402034
  REMARK    GeneRIF: CREG Protects Retinal Ganglion Cells loss and Retinal
            Function Impairment Against ischemia-reperfusion Injury in mice via
            Akt Signaling Pathway.
REFERENCE   2  (residues 1 to 220)
  AUTHORS   Liu D, Xing R, Zhang Q, Tian X, Qi Y, Song H, Liu Y, Yu H, Zhang X,
            Jing Q, Yan C and Han Y.
  TITLE     The CREG1-FBXO27-LAMP2 axis alleviates diabetic cardiomyopathy by
            promoting autophagy in cardiomyocytes
  JOURNAL   Exp Mol Med 55 (9), 2025-2038 (2023)
   PUBMED   37658156
  REMARK    GeneRIF: The CREG1-FBXO27-LAMP2 axis alleviates diabetic
            cardiomyopathy by promoting autophagy in cardiomyocytes.
REFERENCE   3  (residues 1 to 220)
  AUTHORS   Song H, Li J, Peng C, Liu D, Mei Z, Yang Z, Tian X, Zhang X, Jing
            Q, Yan C and Han Y.
  TITLE     The role of CREG1 in megakaryocyte maturation and
            thrombocytopoiesis
  JOURNAL   Int J Biol Sci 19 (11), 3614-3627 (2023)
   PUBMED   37496998
  REMARK    GeneRIF: The role of CREG1 in megakaryocyte maturation and
            thrombocytopoiesis.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 220)
  AUTHORS   Goto A, Endo Y and Yamashita H.
  TITLE     CREG1 stimulates AMPK phosphorylation and glucose uptake in
            skeletal muscle cells
  JOURNAL   Biochem Biophys Res Commun 641, 162-167 (2023)
   PUBMED   36528955
  REMARK    GeneRIF: CREG1 stimulates AMPK phosphorylation and glucose uptake
            in skeletal muscle cells.
REFERENCE   5  (residues 1 to 220)
  AUTHORS   Wu M, Yin F, Wei X, Ren R, Chen C, Liu M, Wang R, Yang L, Xie R,
            Jiang S, Wang Z, Liu R, Xu W, Wang X, Li J and Wang H.
  TITLE     Hepatocyte-specific deletion of cellular repressor of
            E1A-stimulated genes 1 exacerbates alcohol-induced liver injury by
            activating stress kinases
  JOURNAL   Int J Biol Sci 18 (4), 1612-1626 (2022)
   PUBMED   35280676
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 220)
  AUTHORS   Schahs P, Weidinger P, Probst OC, Svoboda B, Stadlmann J, Beug H,
            Waerner T and Mach L.
  TITLE     Cellular repressor of E1A-stimulated genes is a bona fide lysosomal
            protein which undergoes proteolytic maturation during its
            biosynthesis
  JOURNAL   Exp Cell Res 314 (16), 3036-3047 (2008)
   PUBMED   18621046
  REMARK    GeneRIF: Results show that CREG is a lysosomal protein that
            undergoes proteolytic maturation during biosynthesis, carries the
            mannose 6-phosphate recognition marker and depends on the
            interaction with M-6-P receptors for efficient delivery to
            lysosomes.
REFERENCE   7  (residues 1 to 220)
  AUTHORS   Peters LL, Zhang W, Lambert AJ, Brugnara C, Churchill GA and Platt
            OS.
  TITLE     Quantitative trait loci for baseline white blood cell count,
            platelet count, and mean platelet volume
  JOURNAL   Mamm Genome 16 (10), 749-763 (2005)
   PUBMED   16261417
REFERENCE   8  (residues 1 to 220)
  AUTHORS   Kunita R, Otomo A and Ikeda JE.
  TITLE     Identification and characterization of novel members of the CREG
            family, putative secreted glycoproteins expressed specifically in
            brain
  JOURNAL   Genomics 80 (5), 456-460 (2002)
   PUBMED   12408961
REFERENCE   9  (residues 1 to 220)
  AUTHORS   Veal E, Groisman R, Eisenstein M and Gill G.
  TITLE     The secreted glycoprotein CREG enhances differentiation of NTERA-2
            human embryonal carcinoma cells
  JOURNAL   Oncogene 19 (17), 2120-2128 (2000)
   PUBMED   10815803
REFERENCE   10 (residues 1 to 220)
  AUTHORS   Veal E, Eisenstein M, Tseng ZH and Gill G.
  TITLE     A cellular repressor of E1A-stimulated genes that inhibits
            activation by E2F
  JOURNAL   Mol Cell Biol 18 (9), 5032-5041 (1998)
   PUBMED   9710587
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124587.5 and AW495378.1.
            
            On Sep 16, 2004 this sequence version replaced XP_358337.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027426.1, AK144101.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..220
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 73.11 cM"
     Protein         1..220
                     /product="protein CREG1 precursor"
                     /note="protein CREG1"
                     /calculated_mol_wt=21455
     sig_peptide     1..31
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=3015
     Region          30..53
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O88668.1)"
     Region          50..216
                     /region_name="Pyrid_oxidase_2"
                     /note="Pyridoxamine 5'-phosphate oxidase; pfam13883"
                     /db_xref="CDD:404723"
     Site            160
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O88668.1)"
     Site            216
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O88668.1)"
     CDS             1..220
                     /gene="Creg1"
                     /gene_synonym="Creg"
                     /coded_by="NM_011804.3:28..690"
                     /db_xref="CCDS:CCDS35759.1"
                     /db_xref="GeneID:433375"
                     /db_xref="MGI:MGI:1344382"
ORIGIN      
        1 maarapelar sllaallapa lvallvspas grggrdhgdw dvdrrlpplp predgprvar
       61 fvthvsdwgs latistikev rgwpfadiis isdgppgegt gepymylspl qqavsdlqen
      121 peatltmsla qtvycrnhgf dpqsplcvhi mmsgtvtkvn kteedyards lfvrhpemkh
      181 wpsshnwffa klkisriwvl dyfggpkvvt peeyfnvtlq
//
LOCUS       NP_001351352             726 aa            linear   ROD 09-OCT-2023
DEFINITION  pro-neuregulin-1, membrane-bound isoform isoform 4 [Mus musculus].
ACCESSION   NP_001351352 XP_006509132
VERSION     NP_001351352.1
DBSOURCE    REFSEQ: accession NM_001364423.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 726)
  AUTHORS   Mikami Y, Iwase F, Ohshima D, Tomida T and Adachi-Akahane S.
  TITLE     Compensatory role of neuregulin-1 in diabetic cardiomyopathy
  JOURNAL   J Pharmacol Sci 153 (3), 130-141 (2023)
   PUBMED   37770154
  REMARK    GeneRIF: Compensatory role of neuregulin-1 in diabetic
            cardiomyopathy.
REFERENCE   2  (residues 1 to 726)
  AUTHORS   Qiao XY, Wang Y, Zhang W, Li Q, Liu C, Dao JJ, Qiao CM, Cui C, Shen
            YQ and Zhao WJ.
  TITLE     Involvement of CXCL10 in Neuronal Damage under the Condition of
            Spinal Cord Injury and the Potential Therapeutic Effect of Nrg1
  JOURNAL   J Integr Neurosci 22 (4), 96 (2023)
   PUBMED   37519170
  REMARK    GeneRIF: Involvement of CXCL10 in Neuronal Damage under the
            Condition of Spinal Cord Injury and the Potential Therapeutic
            Effect of Nrg1.
REFERENCE   3  (residues 1 to 726)
  AUTHORS   Liu H, Lu P, He S, Luo Y, Fang Y, Benkaci S, Wu B, Wang Y and Zhou
            B.
  TITLE     beta-Catenin regulates endocardial cushion growth by suppressing
            p21
  JOURNAL   Life Sci Alliance 6 (9), e202302163 (2023)
   PUBMED   37385754
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 726)
  AUTHORS   Kong L, Hassinan CW, Gerstner F, Buettner JM, Petigrow JB, Valdivia
            DO, Chan-Cortes MH, Mistri A, Cao A, McGaugh SA, Denton M, Brown S,
            Ross J, Schwab MH, Simon CM and Sumner CJ.
  TITLE     Boosting neuregulin 1 type-III expression hastens SMA motor axon
            maturation
  JOURNAL   Acta Neuropathol Commun 11 (1), 53 (2023)
   PUBMED   36997967
  REMARK    GeneRIF: Boosting neuregulin 1 type-III expression hastens SMA
            motor axon maturation.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 726)
  AUTHORS   Zhang X, Xiao G, Johnson C, Cai Y, Horowitz ZK, Mennicke C, Coffey
            R, Haider M, Threadgill D, Eliscu R, Oldham MC, Greenbaum A and
            Ghashghaei HT.
  TITLE     Bulk and mosaic deletions of Egfr reveal regionally defined
            gliogenesis in the developing mouse forebrain
  JOURNAL   iScience 26 (3), 106242 (2023)
   PUBMED   36915679
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 726)
  AUTHORS   Gassmann M, Casagranda F, Orioli D, Simon H, Lai C, Klein R and
            Lemke G.
  TITLE     Aberrant neural and cardiac development in mice lacking the ErbB4
            neuregulin receptor
  JOURNAL   Nature 378 (6555), 390-394 (1995)
   PUBMED   7477376
REFERENCE   7  (residues 1 to 726)
  AUTHORS   Meyer,D. and Birchmeier,C.
  TITLE     Multiple essential functions of neuregulin in development
  JOURNAL   Nature 378 (6555), 386-390 (1995)
   PUBMED   7477375
  REMARK    Erratum:[Nature 1995 Dec 14;378(6558):753]
REFERENCE   8  (residues 1 to 726)
  AUTHORS   Moscoso LM, Chu GC, Gautam M, Noakes PG, Merlie JP and Sanes JR.
  TITLE     Synapse-associated expression of an acetylcholine receptor-inducing
            protein, ARIA/heregulin, and its putative receptors, ErbB2 and
            ErbB3, in developing mammalian muscle
  JOURNAL   Dev Biol 172 (1), 158-169 (1995)
   PUBMED   7589796
REFERENCE   9  (residues 1 to 726)
  AUTHORS   Yang Y, Spitzer E, Meyer D, Sachs M, Niemann C, Hartmann G, Weidner
            KM, Birchmeier C and Birchmeier W.
  TITLE     Sequential requirement of hepatocyte growth factor and neuregulin
            in the morphogenesis and differentiation of the mammary gland
  JOURNAL   J Cell Biol 131 (1), 215-226 (1995)
   PUBMED   7559778
REFERENCE   10 (residues 1 to 726)
  AUTHORS   Ho WH, Armanini MP, Nuijens A, Phillips HS and Osheroff PL.
  TITLE     Sensory and motor neuron-derived factor. A novel heregulin variant
            highly expressed in sensory and motor neurons
  JOURNAL   J Biol Chem 270 (24), 14523-14532 (1995)
   PUBMED   7782315
  REMARK    Erratum:[J Biol Chem. 1995 Nov 3;270(44):26722. PMID: 7592900]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132407.3 and AC127374.4.
            
            On Jun 16, 2018 this sequence version replaced XP_006509132.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660821.82550.1,
                                           SRR1660811.90461.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..726
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 18.75 cM"
     Protein         1..726
                     /product="pro-neuregulin-1, membrane-bound isoform isoform
                     4"
                     /note="heregulin; type III neuregulin 1; type I neuregulin
                     1; pro-neuregulin-1, membrane-bound isoform"
                     /calculated_mol_wt=79553
     Region          245..275
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Region          353..708
                     /region_name="Neuregulin"
                     /note="Neuregulin family; pfam02158"
                     /db_xref="CDD:426627"
     CDS             1..726
                     /gene="Nrg1"
                     /gene_synonym="6030402G23Rik; ARIA; D230005F13Rik; GGF;
                     GGFII; Hgl; HRG; HRGalpha; NDF; Pro-NRG1; SMDF"
                     /coded_by="NM_001364423.1:641..2821"
                     /note="isoform 4 is encoded by transcript variant 4"
                     /db_xref="GeneID:211323"
                     /db_xref="MGI:MGI:96083"
ORIGIN      
        1 meiyppdmse gaggrsssps tqlsadpsld glpaaehmpd thtedgrspg llglavpccv
       61 cleaerlrgc lnsekicivp ilaclvslcl ciaglkwvfv dkifeydspt hldpgglgqd
      121 pvisldptaa savlvsseay tspvskaqse aeahvtgqgd hvavasepsa vptrknrlsa
      181 fpplhstppp fpspartpev rtpksgtqpq ttetnlqtap klstststtg tshlikcaek
      241 ektfcvngge cfmvkdlsnp srylckcpne ftgdrcqnyv masfymtsrr krqetekple
      301 rkldhslvke tkhlgiefme aeelyqkrvl titgiciall vvgimcvvay cktkkqrqkl
      361 hdrlrqslrs ernnmvnian gphhpnpppe nvqlvnqyvs knvissehiv erevetsfst
      421 shytstahhs ttvtqtpshs wsnghtesii seshsvimms svensrhssp aggprgrlhg
      481 lggprecnsf lrharetpds yrdsphsery vsamttparm spvdfhtpss pksppsemsp
      541 pvssmtvsmp svavspfvee erplllvtpp rlrekkydhh pqqlnsfhhn pahqstslpp
      601 splrivedee yettqeyepi qepikkvtns rrakrtkpng hianrlemds npssvssnse
      661 setedervge dtpflgiqnp laaslevapa frlaesrtnp agrfstqeel qarlssvian
      721 qdpiav
//
LOCUS       NP_001278104             702 aa            linear   ROD 09-OCT-2023
DEFINITION  nuclear factor of activated T-cells, cytoplasmic 2 isoform k [Mus
            musculus].
ACCESSION   NP_001278104 XP_006498957
VERSION     NP_001278104.1
DBSOURCE    REFSEQ: accession NM_001291175.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 702)
  AUTHORS   Fu Y, Wang J, Liu C, Liao K, Gao X, Tang R, Fan B, Hong Y, Xiao N,
            Xiao C and Liu WH.
  TITLE     Glycogen synthase kinase 3 controls T-cell exhaustion by regulating
            NFAT activation
  JOURNAL   Cell Mol Immunol 20 (10), 1127-1139 (2023)
   PUBMED   37553428
  REMARK    GeneRIF: Glycogen synthase kinase 3 controls T-cell exhaustion by
            regulating NFAT activation.
REFERENCE   2  (residues 1 to 702)
  AUTHORS   Wan X, Zhao S, Dai Y, Zhang J, Shen Y, Gong L and Le Q.
  TITLE     WNT16b promotes the proliferation and self-renewal of human limbal
            epithelial stem/progenitor cells via activating the
            calcium/calcineurin A/NFATC2 pathway
  JOURNAL   Cell Prolif 56 (10), e13460 (2023)
   PUBMED   36974338
  REMARK    GeneRIF: WNT16b promotes the proliferation and self-renewal of
            human limbal epithelial stem/progenitor cells via activating the
            calcium/calcineurin A/NFATC2 pathway.
REFERENCE   3  (residues 1 to 702)
  AUTHORS   Jiang F, Guo Y, Hu L, Zhang M, Meng J, Si Y and Shi H.
  TITLE     Role of nuclear factor of activated T Cells-1 in Sepsis-induced
            behavioral deficits in mice
  JOURNAL   Brain Res 1806, 148299 (2023)
   PUBMED   36842570
REFERENCE   4  (residues 1 to 702)
  AUTHORS   Nagai J, Lin J and Boyce JA.
  TITLE     Macrophage P2Y6 Receptor Signaling Selectively Activates NFATC2 and
            Suppresses Allergic Lung Inflammation
  JOURNAL   J Immunol 209 (12), 2293-2303 (2022)
   PUBMED   36307120
  REMARK    GeneRIF: Macrophage P2Y6 Receptor Signaling Selectively Activates
            NFATC2 and Suppresses Allergic Lung Inflammation.
REFERENCE   5  (residues 1 to 702)
  AUTHORS   Zhu L, Zhou X, Gu M, Kim J, Li Y, Ko CJ, Xie X, Gao T, Cheng X and
            Sun SC.
  TITLE     Dapl1 controls NFATc2 activation to regulate CD8+ T cell exhaustion
            and responses in chronic infection and cancer
  JOURNAL   Nat Cell Biol 24 (7), 1165-1176 (2022)
   PUBMED   35773432
REFERENCE   6  (residues 1 to 702)
  AUTHORS   Vihma H, Pruunsild P and Timmusk T.
  TITLE     Alternative splicing and expression of human and mouse NFAT genes
  JOURNAL   Genomics 92 (5), 279-291 (2008)
   PUBMED   18675896
REFERENCE   7  (residues 1 to 702)
  AUTHORS   Ho SN, Thomas DJ, Timmerman LA, Li X, Francke U and Crabtree GR.
  TITLE     NFATc3, a lymphoid-specific NFATc family member that is
            calcium-regulated and exhibits distinct DNA binding specificity
  JOURNAL   J Biol Chem 270 (34), 19898-19907 (1995)
   PUBMED   7650004
REFERENCE   8  (residues 1 to 702)
  AUTHORS   Jain J, Burgeon E, Badalian TM, Hogan PG and Rao A.
  TITLE     A similar DNA-binding motif in NFAT family proteins and the Rel
            homology region
  JOURNAL   J Biol Chem 270 (8), 4138-4145 (1995)
   PUBMED   7876165
REFERENCE   9  (residues 1 to 702)
  AUTHORS   Li X, Ho SN, Luna J, Giacalone J, Thomas DJ, Timmerman LA, Crabtree
            GR and Francke U.
  TITLE     Cloning and chromosomal localization of the human and murine genes
            for the T-cell transcription factors NFATc and NFATp
  JOURNAL   Cytogenet Cell Genet 68 (3-4), 185-191 (1995)
   PUBMED   7842733
REFERENCE   10 (residues 1 to 702)
  AUTHORS   Ho AM, Jain J, Rao A and Hogan PG.
  TITLE     Expression of the transcription factor NFATp in a neuronal cell
            line and in the murine nervous system
  JOURNAL   J Biol Chem 269 (45), 28181-28186 (1994)
   PUBMED   7961754
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK135414.1, EU887584.1 and BP757417.1.
            
            On Mar 27, 2014 this sequence version replaced XP_006498957.1.
            
            Transcript Variant: This variant (12, also known as IB-IIS-Xa)
            contains alternate 5' and 3' exon structure, and it thus differs in
            both UTRs, initiates translation at a downstream in-frame start
            codon, and differs in the 3' coding region, compared to variant 1.
            The encoded isoform (k) is shorter at the N-terminus and has a
            distinct C-terminus, compared to isoform a. Both variants 11 and 12
            encode isoform k.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU887584.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..702
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 88.91 cM"
     Protein         1..702
                     /product="nuclear factor of activated T-cells, cytoplasmic
                     2 isoform k"
                     /note="nuclear factor of activated T-cells, cytoplasmic 2;
                     NFAT pre-existing subunit; T-cell transcription factor
                     NFAT1"
                     /calculated_mol_wt=76458
     Region          179..353
                     /region_name="RHD-n_NFAT"
                     /note="N-terminal sub-domain of the Rel homology domain
                     (RHD) of nuclear factor of activated T-cells (NFAT)
                     proteins; cd07881"
                     /db_xref="CDD:143641"
     Site            order(202,205,207..208,210..212,260,301,303..304,318..319,
                     321,352)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143641"
     Region          358..458
                     /region_name="IPT_NFAT"
                     /note="IPT domain of the NFAT family of transcription
                     factors. NFAT transcription complexes are a target of
                     calcineurin, a calcium dependent phosphatase, and activate
                     genes mainly involved in cell-cell-interaction; cd01178"
                     /db_xref="CDD:238583"
     Site            order(382,446)
                     /site_type="DNA binding"
                     /note="DNA binding sites [nucleotide binding]"
                     /db_xref="CDD:238583"
     CDS             1..702
                     /gene="Nfatc2"
                     /gene_synonym="NF-ATc2; NF-ATp; NFAT1; NFAT1-D; Nfatp"
                     /coded_by="NM_001291175.1:318..2426"
                     /note="isoform k is encoded by transcript variant 12"
                     /db_xref="GeneID:18019"
                     /db_xref="MGI:MGI:102463"
ORIGIN      
        1 msprtslaed sclgrhspvp rpasrssspg akrrhscaea lvaplpaasp qrsrspspqp
       61 sphvalqdds ipagypptag savlmdalnt latdspcgip skiwktspdp tpvstapska
      121 glarhiyptv eflgpceqee rrnsapesil lvpptwpkql vpaipicsip vtaslpplew
      181 plsnqsgsye lrievqpkph hrahyetegs rgavkaptgg hpvvqlhgym enkplglqif
      241 igtaderilk phafyqvhri tgktvtttsy ekivgntkvl eiplepknnm ratidcagil
      301 klrnadielr kgetdigrkn trvrlvfrvh vpepsgrivs lqaasnpiec sqrsahelpm
      361 verqdmdscl vyggqqmilt gqnftaeskv vfmekttdgq qiwemeatvd kdksqpnmlf
      421 veipeyrnkh irvpvkvnfy vingkrkrsq pqhftyhpvp aiktepsdey epslicspah
      481 gglgsqpyyp qhpmlaesps clvatmapcq qfrsglsspd aryqqqspaa alyqrsksls
      541 pgllgyqqps llaaplglad ahrsvlvhag sqgqgqgstl phtssasqqa spvihysptn
      601 qqlrggghqe fqhimycenf gpssarpgpp pinqgqrlsp gayptviqqq tapsqraakn
      661 gpsdqkealp tgvtvkqeqn ldqtylddel idthlswiqn il
//
LOCUS       NP_001349221             512 aa            linear   ROD 09-OCT-2023
DEFINITION  CUGBP Elav-like family member 4 isoform 17 [Mus musculus].
ACCESSION   NP_001349221
VERSION     NP_001349221.1
DBSOURCE    REFSEQ: accession NM_001362292.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 512)
  AUTHORS   Salamon I, Park Y, Miskic T, Kopic J, Matteson P, Page NF, Roque A,
            McAuliffe GW, Favate J, Garcia-Forn M, Shah P, Judas M, Millonig
            JH, Kostovic I, De Rubeis S, Hart RP, Krsnik Z and Rasin MR.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    GeneRIF: Celf4 controls mRNA translation underlying synaptic
            development in the prenatal mammalian neocortex.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 512)
  AUTHORS   Shen Y, Zhang C, Xiao K, Liu D and Xie G.
  TITLE     CELF4 regulates spine formation and depression-like behaviors of
            mice
  JOURNAL   Biochem Biophys Res Commun 605, 39-44 (2022)
   PUBMED   35306363
  REMARK    GeneRIF: CELF4 regulates spine formation and depression-like
            behaviors of mice.
REFERENCE   3  (residues 1 to 512)
  AUTHORS   Moreau MX, Saillour Y, Cwetsch AW, Pierani A and Causeret F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   4  (residues 1 to 512)
  AUTHORS   Li C, Li X, Bi Z, Sugino K, Wang G, Zhu T and Liu Z.
  TITLE     Comprehensive transcriptome analysis of cochlear spiral ganglion
            neurons at multiple ages
  JOURNAL   Elife 9, e50491 (2020)
   PUBMED   31913118
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 512)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 512)
  AUTHORS   Ladd AN, Taffet G, Hartley C, Kearney DL and Cooper TA.
  TITLE     Cardiac tissue-specific repression of CELF activity disrupts
            alternative splicing and causes cardiomyopathy
  JOURNAL   Mol Cell Biol 25 (14), 6267-6278 (2005)
   PUBMED   15988035
  REMARK    GeneRIF: CELF protein activity is required for normal alternative
            splicing in the heart in vivo and normal CELF-mediated alternative
            splicing regulation is in turn required for normal cardiac
            function.
REFERENCE   7  (residues 1 to 512)
  AUTHORS   Meins M, Schlickum S, Wilhelm C, Missbach J, Yadav S, Glaser B,
            Grzmil M, Burfeind P and Laccone F.
  TITLE     Identification and characterization of murine Brunol4, a new member
            of the elav/bruno family
  JOURNAL   Cytogenet Genome Res 97 (3-4), 254-260 (2002)
   PUBMED   12438720
  REMARK    GeneRIF: cloning and characterization
REFERENCE   8  (residues 1 to 512)
  AUTHORS   Ladd AN, Charlet N and Cooper TA.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   9  (residues 1 to 512)
  AUTHORS   Good PJ, Chen Q, Warner SJ and Herring DC.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
REFERENCE   10 (residues 1 to 512)
  AUTHORS   Yulug IG, Egan SE, See CG and Fisher EM.
  TITLE     Mapping GRB2, a signal transduction gene in the human and the mouse
  JOURNAL   Genomics 22 (2), 313-318 (1994)
   PUBMED   7806216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121094.8 and AC144938.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.38660.1,
                                           SRR17784646.1120943.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..512
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 13.92 cM"
     Protein         1..512
                     /product="CUGBP Elav-like family member 4 isoform 17"
                     /note="CUG-BP- and ETR-3-like factor 4; bruno-like protein
                     4; RNA-binding protein BRUNOL-4; bruno-like 4, RNA binding
                     protein"
                     /calculated_mol_wt=54499
     Region          49..135
                     /region_name="RRM1_CELF3_4_5_6"
                     /note="RNA recognition motif 1 (RRM1) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12632"
                     /db_xref="CDD:410041"
     Site            order(55,57,59..60,63,82,84,86,95..97,99,129,131)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410041"
     Region          140..220
                     /region_name="RRM2_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12635"
                     /db_xref="CDD:410043"
     Site            order(142,144,146..147,150,169,171,173,181..183,185,215,
                     217)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410043"
     Region          405..501
                     /region_name="RRM3_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12639"
                     /db_xref="CDD:241083"
     CDS             1..512
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /coded_by="NM_001362292.1:531..2069"
                     /note="isoform 17 is encoded by transcript variant 23"
                     /db_xref="GeneID:108013"
                     /db_xref="MGI:MGI:1932407"
ORIGIN      
        1 myikmatlan gqadnaslst nglgsspgsa ghmnglshsp gnpstipmkd hdaiklfigq
       61 iprnldekdl kplfeefgki yeltvlkdrf tgmhkgcafl tyceresalk aqsalheqkt
      121 lpgmnrpiqv kpadsesrgd rklfvgmlnk qqseddvrrl feafgnieec tilrgpdgns
      181 kgcafvkyss haeaqaaina lhgsqtmpga ssslvvkfad tdkertmrrm qqmagqmgmf
      241 npmaipfgay gayaqalmqq qaalmasvaq ggylnpmaaf aaaqmqqmaa lnmnglaaap
      301 mtptsggstp pgitapavps ipspigvngf tglppqangq paaeavfang ihpypaqspt
      361 aadplqqaya gvqqyagpay paaygqisqa fpqpppmipq qqregpegcn lliyhlpqef
      421 gdaelmqmfl pfgnvisskv fvdratnqsk cfaapggpve tqalvprvsp gfvsfdnpas
      481 aqtaiqamng fqigmkrlkv qlkrpkdanr py
//
LOCUS       NP_001346488              81 aa            linear   ROD 09-OCT-2023
DEFINITION  costars family protein ABRACL [Mus musculus].
ACCESSION   NP_001346488
VERSION     NP_001346488.1
DBSOURCE    REFSEQ: accession NM_001359559.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 81)
  AUTHORS   Troumpoukis D, Vasileiou AR, Siskos N, Stylianopoulou E, Ypsilantis
            P, Skavdis G and Grigoriou ME.
  TITLE     Characterization of the Abracl-Expressing Cell Populations in the
            Embryonic Mammalian Telencephalon
  JOURNAL   Biomolecules 13 (9), 1337 (2023)
   PUBMED   37759737
  REMARK    GeneRIF: Characterization of the Abracl-Expressing Cell Populations
            in the Embryonic Mammalian Telencephalon.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 81)
  AUTHORS   Pensold D, Symmank J, Hahn A, Lingner T, Salinas-Riester G, Downie
            BR, Ludewig F, Rotzsch A, Haag N, Andreas N, Schubert K, Hubner CA,
            Pieler T and Zimmer G.
  TITLE     The DNA Methyltransferase 1 (DNMT1) Controls the Shape and Dynamics
            of Migrating POA-Derived Interneurons Fated for the Murine Cerebral
            Cortex
  JOURNAL   Cereb Cortex 27 (12), 5696-5714 (2017)
   PUBMED   29117290
REFERENCE   3  (residues 1 to 81)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   4  (residues 1 to 81)
  AUTHORS   Nelson PS, Pritchard C, Abbott D and Clegg N.
  TITLE     The human (PEDB) and mouse (mPEDB) Prostate Expression Databases
  JOURNAL   Nucleic Acids Res 30 (1), 218-220 (2002)
   PUBMED   11752298
REFERENCE   5  (residues 1 to 81)
  AUTHORS   Kagami Y and Furuichi T.
  TITLE     Investigation of differentially expressed genes during the
            development of mouse cerebellum
  JOURNAL   Brain Res Gene Expr Patterns 1 (1), 39-59 (2001)
   PUBMED   15018818
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153896.10, AK013984.1 and AW492391.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK013984.1, BG804701.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..81
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 7.39 cM"
     Protein         1..81
                     /product="costars family protein ABRACL"
                     /note="ABRA C-terminal-like protein"
                     /calculated_mol_wt=8927
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:Q9P1F3; propagated from
                     UniProtKB/Swiss-Prot (Q4KML4.1)"
     Region          2..79
                     /region_name="Costars"
                     /note="pfam14705"
                     /db_xref="CDD:434145"
     CDS             1..81
                     /gene="Abracl"
                     /gene_synonym="1700028I04Rik; 3110003A17Rik"
                     /coded_by="NM_001359559.1:189..434"
                     /db_xref="CCDS:CCDS48506.1"
                     /db_xref="GeneID:73112"
                     /db_xref="MGI:MGI:1920362"
ORIGIN      
        1 mnvehevnll veeihrlgsr nadgklsvkf gvlfqddrca nlfealvgtl kaakrrkivt
       61 yagelllqgv hddvdivllq d
//
LOCUS       NP_034363               2477 aa            linear   ROD 09-OCT-2023
DEFINITION  fibronectin isoform a precursor [Mus musculus].
ACCESSION   NP_034363 XP_129845
VERSION     NP_034363.1
DBSOURCE    REFSEQ: accession NM_010233.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 2477)
  AUTHORS   Huo X, Ma S, Wang C, Song L, Yao B, Zhu S, Li P, Wang L, Wu Z and
            Wang K.
  TITLE     Unravelling the role of immune cells and FN1 in the recurrence and
            therapeutic process of skull base chordoma
  JOURNAL   Clin Transl Med 13 (10), e1429 (2023)
   PUBMED   37784253
  REMARK    GeneRIF: Unravelling the role of immune cells and FN1 in the
            recurrence and therapeutic process of skull base chordoma.
REFERENCE   2  (residues 1 to 2477)
  AUTHORS   Whisler J, Shahreza S, Schlegelmilch K, Ege N, Javanmardi Y,
            Malandrino A, Agrawal A, Fantin A, Serwinski B, Azizgolshani H,
            Park C, Shone V, Demuren OO, Del Rosario A, Butty VL, Holroyd N,
            Domart MC, Hooper S, Szita N, Boyer LA, Walker-Samuel S, Djordjevic
            B, Sheridan GK, Collinson L, Calvo F, Ruhrberg C, Sahai E, Kamm R
            and Moeendarbary E.
  TITLE     Emergent mechanical control of vascular morphogenesis
  JOURNAL   Sci Adv 9 (32), eadg9781 (2023)
   PUBMED   37566656
REFERENCE   3  (residues 1 to 2477)
  AUTHORS   Jena SK, Das S, Chakraborty S and Ain R.
  TITLE     Molecular determinants of epithelial mesenchymal transition in
            mouse placenta and trophoblast stem cell
  JOURNAL   Sci Rep 13 (1), 10978 (2023)
   PUBMED   37414855
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 2477)
  AUTHORS   Hiver S, Shimizu-Mizuno N, Ikawa Y, Kajikawa E, Sai X, Nishimura H,
            Takaoka K, Nishimura O, Kuraku S, Tanaka S and Hamada H.
  TITLE     Gse1, a component of the CoREST complex, is required for placenta
            development in the mouse
  JOURNAL   Dev Biol 498, 97-105 (2023)
   PUBMED   37019373
REFERENCE   5  (residues 1 to 2477)
  AUTHORS   Ozguldez HO, Govindasamy N, Fan R, Long H, Mildner K, Zeuschner D,
            Trappmann B, Ranga A and Bedzhov I.
  TITLE     Polarity inversion reorganizes the stem cell compartment of the
            trophoblast lineage
  JOURNAL   Cell Rep 42 (4), 112313 (2023)
   PUBMED   36989113
REFERENCE   6  (residues 1 to 2477)
  AUTHORS   Saga Y, Yagi T, Ikawa Y, Sakakura T and Aizawa S.
  TITLE     Mice develop normally without tenascin
  JOURNAL   Genes Dev 6 (10), 1821-1831 (1992)
   PUBMED   1383086
REFERENCE   7  (residues 1 to 2477)
  AUTHORS   Khandjian EW, Salomon C, Leonard N, Tremblay S and Turler H.
  TITLE     Fibronectin gene expression in proliferating, quiescent, and
            SV40-infected mouse kidney cells
  JOURNAL   Exp Cell Res 202 (2), 464-470 (1992)
   PUBMED   1327855
REFERENCE   8  (residues 1 to 2477)
  AUTHORS   Vidal SM, Epstein DJ, Malo D, Weith A, Vekemans M and Gros P.
  TITLE     Identification and mapping of six microdissected genomic DNA probes
            to the proximal region of mouse chromosome 1
  JOURNAL   Genomics 14 (1), 32-37 (1992)
   PUBMED   1358796
REFERENCE   9  (residues 1 to 2477)
  AUTHORS   Malo D, Schurr E, Epstein DJ, Vekemans M, Skamene E and Gros P.
  TITLE     The host resistance locus Bcg is tightly linked to a group of
            cytoskeleton-associated protein genes that include villin and
            desmin
  JOURNAL   Genomics 10 (2), 356-364 (1991)
   PUBMED   1676979
REFERENCE   10 (residues 1 to 2477)
  AUTHORS   Wartiovaara,J., Leivo,I. and Vaheri,A.
  TITLE     Expression of the cell surface-associated glycoprotein,
            fibronectin, in the early mouse embryo
  JOURNAL   Dev Biol 69 (1), 247-257 (1979)
   PUBMED   376373
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ098561.1, CN534124.1, CF166960.1, CK638401.1, CK637170.1,
            CN538894.1, CN694596.1, CF727068.1, CN460535.1, AK133868.1 and
            AC124821.5.
            
            On Aug 30, 2004 this sequence version replaced XP_129845.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK090135.1, AK090130.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2477
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 36.05 cM"
     Protein         1..2477
                     /product="fibronectin isoform a precursor"
                     /calculated_mol_wt=269760
     sig_peptide     1..27
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=2797
     Region          53..90
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain, approximately 40 residue
                     long with two conserved disulfide bridges. FN1 is one of
                     three types of internal repeats which combine to form
                     larger domains within fibronectin. Fibronectin, a plasma
                     protein that binds cell surfaces...; cd00061"
                     /db_xref="CDD:238018"
     Region          98..141
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          142..185
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          187..231
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          232..271
                     /region_name="fn1"
                     /note="Fibronectin type I domain; pfam00039"
                     /db_xref="CDD:425437"
     Region          308..347
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          353..401
                     /region_name="FN2"
                     /note="Fibronectin type 2 domain; smart00059"
                     /db_xref="CDD:128373"
     Site            order(364,366,371,385,392,398,400)
                     /site_type="active"
                     /note="putative gelatin-binding site [active]"
                     /db_xref="CDD:238019"
     Region          413..461
                     /region_name="FN2"
                     /note="Fibronectin type 2 domain; smart00059"
                     /db_xref="CDD:128373"
     Site            order(424,426,431,445,452,458,460)
                     /site_type="active"
                     /note="putative gelatin-binding site [active]"
                     /db_xref="CDD:238019"
     Region          470..513
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          518..560
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          561..604
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          619..688
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Region          726..797
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(797..798,800..801)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Site            order(810,871,886)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Region          811..882
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(887..888,890..891)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          907..987
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(984..985,987..988)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          997..1075
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(1073..1074,1076..1077)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1091..1158
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Region          1174..1257
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(1254..1255,1257..1258)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Site            order(1264,1329,1344)
                     /site_type="active"
                     /note="Interdomain contacts [active]"
                     /db_xref="CDD:238020"
     Region          1267..1349
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(1345..1346,1348..1349)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1358..1439
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Region          1449..1529
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Region          1541..1620
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(1616..1617,1619..1620)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1633..1713
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(1710..1711,1713..1714)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1723..1803
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Region          1813..1893
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(1890..1891,1893..1894)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1905..1984
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Site            order(1981..1982,1984..1985)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Region          1994..2074
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Region          2210..2265
                     /region_name="fn3"
                     /note="Fibronectin type III domain; pfam00041"
                     /db_xref="CDD:394996"
     Region          2296..2340
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          2341..2382
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain; smart00058"
                     /db_xref="CDD:214494"
     Region          2384..2423
                     /region_name="FN1"
                     /note="Fibronectin type 1 domain, approximately 40 residue
                     long with two conserved disulfide bridges. FN1 is one of
                     three types of internal repeats which combine to form
                     larger domains within fibronectin. Fibronectin, a plasma
                     protein that binds cell surfaces...; cd00061"
                     /db_xref="CDD:238018"
     CDS             1..2477
                     /gene="Fn1"
                     /gene_synonym="E330027I09; Fn; Fn-1"
                     /coded_by="NM_010233.2:253..7686"
                     /note="isoform a precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS15031.1"
                     /db_xref="GeneID:14268"
                     /db_xref="MGI:MGI:95566"
ORIGIN      
        1 mlrgpgpgrl lllavlclgt svrcteagks krqaqqivqp qspvavsqsk pgcfdngkhy
       61 qinqqwerty lgnalvctcy ggsrgfnces kpepeetcfd kytgntykvg dtyerpkdsm
      121 iwdctcigag rgrisctian rcheggqsyk igdkwrrphe tggymleclc lgngkgewtc
      181 kpiaekcfdh aagtsyvvge twekpyqgwm mvdctclgeg ngritctsrn rcndqdtrts
      241 yrigdtwskk dnrgnllqcv ctgngrgewk cerhalqsas agsgsftdvr taiyqpqthp
      301 qpapyghcvt dsgvvysvgm qwlksqgnkq mlctclgngv scqetavtqt yggnsngepc
      361 vlpftyngrt fyscttegrq dghlwcstts nyeqdqkysf ctdhavlvqt rggnsngalc
      421 hfpflynnrn ytdctsegrr dnmkwcgttq nydadqkfgf cpmaaheeic ttnegvmyri
      481 gdqwdkqhdl ghmmrctcvg ngrgewacip ysqlrdqciv dditynvndt fhkrheeghm
      541 lnctcfgqgr grwkcdpidq cqdsetrtfy qigdswekfv hgvryqcycy grgigewhcq
      601 plqtypgttg pvqviitetp sqpnshpiqw napepshitk yilrwrpkts tgrwkeatip
      661 ghlnsytikg ltpgviyegq lisiqqyghr evtrfdftts astpvtsntv tgetapyspv
      721 vatsesvtei tassfvvswv sasdtvsgfr veyelseegd epqyldlpst atsvnipdll
      781 pgrkyivnvy qiseegkqsl ilstsqttap dappdptvdq vddtsivvrw srpqapitgy
      841 rivyspsveg sstelnlpet ansvtlsdlq pgvqynitiy aveenqestp vfiqqettgt
      901 prsdnvpppt dlqfveltdv kvtimwtppd svvsgyrvev lpvslpgehg qrlpvnrntf
      961 aeitglspgv tylfkvfavh qgresnplta qqttkldapt nlqfvnetdr tvlvtwtppr
     1021 ariagyrlta gltrggqpkq ynvgplasky plrnlqpgse ytvtlvavkg nqqspkatgv
     1081 fttlqplrsi ppyntevtet tivitwtpap rigfklgvrp sqggeaprev tsdsgsivvs
     1141 gltpgveyty tiqvlrdgqe rdapivnrvv tplspptnlh leanpdtgvl tvswersttp
     1201 ditgyrittt ptngqqgtsl eevvhadqss ctfenlnpgl eynvsvytvk ddkesapisd
     1261 tvvpevpqlt dlsfvditds siglrwtpln sstiigyrit vvaagegipi fedfvdssvg
     1321 yytvtglepg idydisvitl inggesaptt ltqqtavppp tdlrftnigp dtmrvtwapp
     1381 psieltnllv ryspvkneed vaelsispsd navvltnllp gteylvsvss vyeqhesipl
     1441 rgrqktglds ptgfdssdit ansftvhwva prapitgyii rhhaehsvgr prqdrvppsr
     1501 nsitltnlnp gteyvvsiia vngreesppl igqqatvsdi prdleviast ptslliswep
     1561 pavsvryyri tygetggnsp vqeftvpgsk statinnikp gadytitlya vtgrgdspas
     1621 skpvsinykt eidkpsqmqv tdvqdnsisv rwlpstspvt gyrvtttpkn glgpsktkta
     1681 spdqtemtie glqptveyvv svyaqnrnge sqplvqtavt nidrpkglaf tdvdvdsiki
     1741 awespqgqvs ryrvtysspe dgirelfpap dgeddtaelq glrpgseytv svvalhddme
     1801 sqpligiqst aipaptnlkf sqvtptsfta qwiapsvqlt gyrvrvnpke ktgpmkeinl
     1861 spdsssvivs glmvatkyev svyalkdtlt srpaqgvitt lenvspprra rvtdatetti
     1921 tiswrtktet itgfqvdaip angqtpvqrs ispdvrsyti tglqpgtdyk ihlytlndna
     1981 rsspviidas taidapsnlr fltttpnsll vswqaprari tgyiikyekp gspprevvpr
     2041 prpgvteati tglepgteyt iyvialknnq ksepligrkk tdelpqlvtl phpnlhgpei
     2101 ldvpstvqkt pfitnpgydt engiqlpgtt hqqpsvgqqm ifeehgfrrt tpptaatpvr
     2161 lrprpylpnv deevqighvp rgdvdyhlyp hvpglnpnas tgqealsqtt iswtpfqess
     2221 eyiiscqpvg tdeeplqfqv pgtstsatlt gltrgvtyni ivealqnqrr hkvreevvtv
     2281 gnavseglnq ptddscfdpy tvshyaigee werlsdagfk ltcqclgfgs ghfrcdsskw
     2341 chdngvnyki gekwdrqgen gqrmsctclg ngkgefkcdp heatcyddgk tyhvgeqwqk
     2401 eylgaicsct cfggqrgwrc dncrrpgaae pspdgttght ynqytqrynq rtntnvncpi
     2461 ecfmpldvqa drddsre
//
LOCUS       NP_001397153             534 aa            linear   ROD 09-OCT-2023
DEFINITION  nuclear respiratory factor 1 isoform b [Mus musculus].
ACCESSION   NP_001397153 XP_036021813
VERSION     NP_001397153.1
DBSOURCE    REFSEQ: accession NM_001410224.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 534)
  AUTHORS   Cheng C, Tian Y, Yang R, Guo W, Xiao K, Zhang F, Tian J, Deng Z,
            Yang W, Yang H and Zhou Z.
  TITLE     miR-5581 Contributes to Osteoarthritis by Targeting NRF1 to Disturb
            the Proliferation and Functions of Chondrocytes
  JOURNAL   Am J Pathol 193 (9), 1234-1247 (2023)
   PUBMED   37611970
  REMARK    GeneRIF: miR-5581 Contributes to Osteoarthritis by Targeting NRF1
            to Disturb the Proliferation and Functions of Chondrocytes.
REFERENCE   2  (residues 1 to 534)
  AUTHORS   Meng Z, Liang B, Wu Y, Liu C, Wang H, Du Y, Gan L, Gao E, Lau WB,
            Christopher TA, Lopez BL, Koch WJ, Ma X, Zhao F, Wang Y and Zhao J.
  TITLE     Hypoadiponectinemia-induced upregulation of microRNA449b
            downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury
            in diabetic mice
  JOURNAL   J Mol Cell Cardiol 182, 1-14 (2023)
   PUBMED   37437402
  REMARK    GeneRIF: Hypoadiponectinemia-induced upregulation of microRNA449b
            downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury
            in diabetic mice.
REFERENCE   3  (residues 1 to 534)
  AUTHORS   Zhao T, Zhang J, Lei H, Meng Y, Cheng H, Zhao Y, Geng G, Mu C, Chen
            L, Liu Q, Luo Q, Zhang C, Long Y, Su J, Wang Y, Li Z, Sun J, Chen
            G, Li Y, Liao X, Shang Y, Hu G, Chen Q and Zhu Y.
  TITLE     NRF1-mediated mitochondrial biogenesis antagonizes innate antiviral
            immunity
  JOURNAL   EMBO J 42 (16), e113258 (2023)
   PUBMED   37409632
  REMARK    GeneRIF: NRF1-mediated mitochondrial biogenesis antagonizes innate
            antiviral immunity.
REFERENCE   4  (residues 1 to 534)
  AUTHORS   Akl MG, Baccetto R, Stebbings BM, Li L and Widenmaier SB.
  TITLE     Euglycemia is affected by stress defense factor hepatocyte NRF1,
            but not NRF2
  JOURNAL   Biochem Biophys Res Commun 668, 96-103 (2023)
   PUBMED   37245295
  REMARK    GeneRIF: Euglycemia is affected by stress defense factor hepatocyte
            NRF1, but not NRF2.
REFERENCE   5  (residues 1 to 534)
  AUTHORS   Akl MG, Li L, Baccetto R, Phanse S, Zhang Q, Trites MJ, McDonald S,
            Aoki H, Babu M and Widenmaier SB.
  TITLE     Complementary gene regulation by NRF1 and NRF2 protects against
            hepatic cholesterol overload
  JOURNAL   Cell Rep 42 (4), 112399 (2023)
   PUBMED   37060561
  REMARK    GeneRIF: Complementary gene regulation by NRF1 and NRF2 protects
            against hepatic cholesterol overload.
            Erratum:[Cell Rep. 2023 Jul 25;42(7):112872. PMID: 37454293]
REFERENCE   6  (residues 1 to 534)
  AUTHORS   Carmona MC, Iglesias R, Obregon MJ, Darlington GJ, Villarroya F and
            Giralt M.
  TITLE     Mitochondrial biogenesis and thyroid status maturation in brown fat
            require CCAAT/enhancer-binding protein alpha
  JOURNAL   J Biol Chem 277 (24), 21489-21498 (2002)
   PUBMED   11940593
REFERENCE   7  (residues 1 to 534)
  AUTHORS   Huo L and Scarpulla RC.
  TITLE     Mitochondrial DNA instability and peri-implantation lethality
            associated with targeted disruption of nuclear respiratory factor 1
            in mice
  JOURNAL   Mol Cell Biol 21 (2), 644-654 (2001)
   PUBMED   11134350
REFERENCE   8  (residues 1 to 534)
  AUTHORS   Schaefer L, Engman H and Miller JB.
  TITLE     Coding sequence, chromosomal localization, and expression pattern
            of Nrf1: the mouse homolog of Drosophila erect wing
  JOURNAL   Mamm Genome 11 (2), 104-110 (2000)
   PUBMED   10656923
REFERENCE   9  (residues 1 to 534)
  AUTHORS   Huo L and Scarpulla RC.
  TITLE     Multiple 5'-untranslated exons in the nuclear respiratory factor 1
            gene span 47 kb and contribute to transcript heterogeneity and
            translational efficiency
  JOURNAL   Gene 233 (1-2), 213-224 (1999)
   PUBMED   10375638
REFERENCE   10 (residues 1 to 534)
  AUTHORS   Virbasius CA, Virbasius JV and Scarpulla RC.
  TITLE     NRF-1, an activator involved in nuclear-mitochondrial interactions,
            utilizes a new DNA-binding domain conserved in a family of
            developmental regulators
  JOURNAL   Genes Dev 7 (12A), 2431-2445 (1993)
   PUBMED   8253388
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153632.2.
            
            On Aug 1, 2022 this sequence version replaced XP_036021813.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR3363658.906686.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849390
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..534
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 12.47 cM"
     Protein         1..534
                     /product="nuclear respiratory factor 1 isoform b"
                     /note="NRF-1; alpha-pal; alpha palindromic-binding
                     protein"
                     /calculated_mol_wt=57152
     Region          1..78
                     /region_name="Dimerization. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU00.2)"
     Region          36..57
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU00.2)"
     Site            39
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:Q16656; propagated from
                     UniProtKB/Swiss-Prot (Q9WU00.2)"
     Site            44
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:Q16656; propagated from
                     UniProtKB/Swiss-Prot (Q9WU00.2)"
     Site            46
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:Q16656; propagated from
                     UniProtKB/Swiss-Prot (Q9WU00.2)"
     Site            47
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:Q16656; propagated from
                     UniProtKB/Swiss-Prot (Q9WU00.2)"
     Site            52
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:Q16656; propagated from
                     UniProtKB/Swiss-Prot (Q9WU00.2)"
     Region          87..283
                     /region_name="Nrf1_DNA-bind"
                     /note="NLS-binding and DNA-binding and dimerization
                     domains of Nrf1; pfam10491"
                     /db_xref="CDD:402218"
     Region          88..116
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU00.2)"
     Region          450..525
                     /region_name="TGS_YchF_OLA1"
                     /note="TGS (ThrRS, GTPase and SpoT) domain found in the
                     YchF/OLA1 family proteins; cd04867"
                     /db_xref="CDD:340516"
     CDS             1..534
                     /gene="Nrf1"
                     /gene_synonym="D6Ertd415e"
                     /coded_by="NM_001410224.1:1818..3422"
                     /note="isoform b is encoded by transcript variant 14"
                     /db_xref="GeneID:18181"
                     /db_xref="MGI:MGI:1332235"
ORIGIN      
        1 meehgvtqte hmatieahav aqqvqqvhva tytehsmlsa dedspssped tsyddsdiln
       61 staadevtah laaagpvgma aaaavatgkk rkrphvfesn psirkrqqtr llrklratld
      121 eyttrvgqqa ivlcispskp npvfkvfgaa plenvvrkyk smiledlesa laehapapqe
      181 vnselpplti dgipvsvdkm tqaqlrafip emlkystgrg kpgwgkesck piwwpedipw
      241 anvrsdvrte eqkqrvswtq alrtivkncy kqhgredlly afedqqtqtq attthsiahl
      301 vpsqtvvqtf snpdgtvsli qvgtgatvat ladaselptt vtvaqvnysa vadgeveqnw
      361 atlqggemti qttqaseatq avaslaeaav aasqemqqga tvtmalnsea aahavatlae
      421 atlqgggqiv lsgetaaavg altgvqdang pdgvhawtis kavtapqaag kihtdfgkgf
      481 imaevmkded lkeessenaa kaagkykqqg rayvvedgdi iffkfnspqq lkkk
//
LOCUS       NP_038492                805 aa            linear   ROD 09-OCT-2023
DEFINITION  aryl hydrocarbon receptor isoform 1 [Mus musculus].
ACCESSION   NP_038492
VERSION     NP_038492.1
DBSOURCE    REFSEQ: accession NM_013464.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 805)
  AUTHORS   Major J, Crotta S, Finsterbusch K, Chakravarty P, Shah K, Frederico
            B, D'Antuono R, Green M, Meader L, Suarez-Bonnet A, Priestnall S,
            Stockinger B and Wack A.
  TITLE     Endothelial AHR activity prevents lung barrier disruption in viral
            infection
  JOURNAL   Nature 621 (7980), 813-820 (2023)
   PUBMED   37587341
  REMARK    GeneRIF: Endothelial AHR activity prevents lung barrier disruption
            in viral infection.
REFERENCE   2  (residues 1 to 805)
  AUTHORS   Sheu ML, Pan LY, Yang CN, Sheehan J, Pan LY, You WC, Wang CC and
            Pan HC.
  TITLE     Thrombin-Induced Microglia Activation Modulated through Aryl
            Hydrocarbon Receptors
  JOURNAL   Int J Mol Sci 24 (14), 11416 (2023)
   PUBMED   37511175
  REMARK    GeneRIF: Thrombin-Induced Microglia Activation Modulated through
            Aryl Hydrocarbon Receptors.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 805)
  AUTHORS   Balestrieri N, Palzkill V, Pass C, Tan J, Salyers ZR, Moparthy C,
            Murillo A, Kim K, Thome T, Yang Q, O'Malley KA, Berceli SA, Yue F,
            Scali ST, Ferreira LF and Ryan TE.
  TITLE     Activation of the Aryl Hydrocarbon Receptor in Muscle Exacerbates
            Ischemic Pathology in Chronic Kidney Disease
  JOURNAL   Circ Res 133 (2), 158-176 (2023)
   PUBMED   37325935
  REMARK    GeneRIF: Activation of the Aryl Hydrocarbon Receptor in Muscle
            Exacerbates Ischemic Pathology in Chronic Kidney Disease.
REFERENCE   4  (residues 1 to 805)
  AUTHORS   Liu J, Zhang X, Zhang Y, Qian M, Yang M, Yang S and Wang L.
  TITLE     Farnesyl diphosphate synthase exacerbates nonalcoholic
            steatohepatitis via the activation of AHR-CD36 axis
  JOURNAL   FASEB J 37 (7), e23035 (2023)
   PUBMED   37310396
  REMARK    GeneRIF: Farnesyl diphosphate synthase exacerbates nonalcoholic
            steatohepatitis via the activation of AHR-CD36 axis.
REFERENCE   5  (residues 1 to 805)
  AUTHORS   Haque N, Ojo ES, Krager SL and Tischkau SA.
  TITLE     Deficiency of Adipose Aryl Hydrocarbon Receptor Protects against
            Diet-Induced Metabolic Dysfunction through Sexually Dimorphic
            Mechanisms
  JOURNAL   Cells 12 (13), 1748 (2023)
   PUBMED   37443781
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 805)
  AUTHORS   Okey,A.B., Bondy,G.P., Mason,M.E., Kahl,G.F., Eisen,H.J.,
            Guenthner,T.M. and Nebert,D.W.
  TITLE     Regulatory gene product of the Ah locus. Characterization of the
            cytosolic inducer-receptor complex and evidence for its nuclear
            translocation
  JOURNAL   J Biol Chem 254 (22), 11636-11648 (1979)
   PUBMED   500663
REFERENCE   7  (residues 1 to 805)
  AUTHORS   Levitt,R.C., Fysh,J.M., Jensen,N.M. and Nebert,D.W.
  TITLE     The Ah locus: biochemical basis for genetic differences in brain
            tumor formation in mice
  JOURNAL   Genetics 92 (4), 1205-1210 (1979)
   PUBMED   520822
REFERENCE   8  (residues 1 to 805)
  AUTHORS   Wood,A.W. and Taylor,B.A.
  TITLE     Genetic regulation of coumarin hydroxylase activity in mice.
            Evidence for single locus control on chromosome
  JOURNAL   J Biol Chem 254 (13), 5647-5651 (1979)
   PUBMED   447675
REFERENCE   9  (residues 1 to 805)
  AUTHORS   Kouri,R.E., Rude,T.H., Joglekar,R., Dansette,P.M., Jerina,D.M.,
            Atlas,S.A., Owens,I.S. and Nebert,D.W.
  TITLE     2,3,7,8-tetrachlorodibenzo-p-dioxin as cocarcinogen causing
            3-methylcholanthrene-initiated subcutaneous tumors in mice
            genetically 'nonresponsive' at Ah locus
  JOURNAL   Cancer Res 38 (9), 2777-2783 (1978)
   PUBMED   679184
REFERENCE   10 (residues 1 to 805)
  AUTHORS   Thorgeirsson,S.S. and Nebert,D.W.
  TITLE     The Ah locus and the metabolism of chemical carcinogens and other
            foreign compounds
  JOURNAL   Adv Cancer Res 25, 149-193 (1977)
   PUBMED   405846
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK153678.1.
            
            Summary: The protein encoded by this gene is a ligand-activated
            helix-loop-helix transcription factor involved in the regulation of
            biological responses to planar aromatic hydrocarbons. This receptor
            has been shown to regulate xenobiotic-metabolizing enzymes such as
            cytochrome P450. Before ligand binding, the encoded protein is
            sequestered in the cytoplasm; upon ligand binding, this protein
            moves to the nucleus and stimulates transcription of target genes.
            Two transcript variants encoding different isoforms have been found
            for this gene. [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK153678.1, AK155380.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..805
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 15.78 cM"
     Protein         1..805
                     /product="aryl hydrocarbon receptor isoform 1"
                     /note="ah receptor; dioxin receptor"
                     /calculated_mol_wt=90207
     Region          1..38
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R4S5.1)"
     Region          12..15
                     /region_name="Nuclear localization signal 1.
                     /evidence=ECO:0000250|UniProtKB:P35869"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R4S5.1)"
     Region          27..87
                     /region_name="bHLH-PAS_AhR"
                     /note="basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS)
                     domain found in aryl hydrocarbon receptor (AhR) and
                     similar proteins; cd11436"
                     /db_xref="CDD:381442"
     Site            order(33..39,41,43,64..66)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381442"
     Region          36..41
                     /region_name="Nuclear localization signal 2.
                     /evidence=ECO:0000250|UniProtKB:P35869"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R4S5.1)"
     Region          37..65
                     /region_name="DNA-binding.
                     /evidence=ECO:0000250|UniProtKB:P35869"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R4S5.1)"
     Site            order(38,41..42,45..46,48..49,52..56,64..66,69..79,82,
                     85..86)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:381442"
     Region          49..81
                     /region_name="Required for maintaining the overall
                     integrity of the AHR:ARNT heterodimer and its
                     transcriptional activity.
                     /evidence=ECO:0000250|UniProtKB:P35869"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R4S5.1)"
     Region          63..71
                     /region_name="Nuclear export signal.
                     /evidence=ECO:0000250|UniProtKB:P35869"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R4S5.1)"
     Region          111..>177
                     /region_name="PAS"
                     /note="PAS fold; pfam00989"
                     /db_xref="CDD:395786"
     Region          116..124
                     /region_name="Required for maintaining the overall
                     integrity of the AHR:ARNT heterodimer and its
                     transcriptional activity.
                     /evidence=ECO:0000250|UniProtKB:P30561"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R4S5.1)"
     Region          260..262
                     /region_name="Required for maintaining the overall
                     integrity of the AHR:ARNT heterodimer and its
                     transcriptional activity.
                     /evidence=ECO:0000250|UniProtKB:P30561"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R4S5.1)"
     Region          291..376
                     /region_name="PAS_3"
                     /note="PAS fold; pfam08447"
                     /db_xref="CDD:430001"
     Site            order(294,298,304,318..321,347,352)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:238075"
     Site            order(315,319,327,330..331,359,361)
                     /site_type="other"
                     /note="heme pocket [chemical binding]"
                     /db_xref="CDD:238075"
     Region          421..449
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R4S5.1)"
     CDS             1..805
                     /gene="Ahr"
                     /gene_synonym="Ah; Ahh; Ahre; bHLHe76; In"
                     /coded_by="NM_013464.4:367..2784"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS36434.1"
                     /db_xref="GeneID:11622"
                     /db_xref="MGI:MGI:105043"
ORIGIN      
        1 mssganitya srkrrkpvqk tvkpipaegi ksnpskrhrd rlnteldrla sllpfpqdvi
       61 nkldklsvlr lsvsylraks ffdvalkstp adrnggqdqc raqirdwqdl qegefllqal
      121 ngfvlvvtad alvfyassti qdylgfqqsd vihqsvyeli htedraefqr qlhwalnpds
      181 aqgvdeahgp pqaavyytpd qlppenasfm ercfrcrlrc lldnssgfla mnfqgrlkyl
      241 hgqnkkgkdg allppqlalf aiatplqpps ileirtknfi frtkhkldft pigcdakgql
      301 ilgytevelc trgsgyqfih aadilhcaes hirmiktges gmtvfrllak hsrwrwvqsn
      361 arliyrngrp dyiiatqrpl tdeegrehlq krstslpfmf atgeavlyei sspfspimdp
      421 lpirtksnts rkdwapqstp skdsfhpssl msaliqqdes iylcppsspa lldshflmgs
      481 vskcgswqds faaagseaal kheqighaqd vnlalsggps elfpdnknnd lysimrnlgi
      541 dfedirsmqn eeffrtdsta agevdfkdid itdeiltyvq dslnnstlln sacqqqpvtq
      601 hlscmlqerl qleqqqqlqq pppqalepqq qlcqmvcpqq dlgpkhtqin gtfaswnptp
      661 pvsfncpqqe lkhyqlfssl qgtaqefpyk pevdsvpytq nfapcnqpll pehsksvqld
      721 fpgrdfepsl hpttsnldfv sclqvpenqs hginsqsamv spqayyagam smyqcqpgpq
      781 rtpvdqtqys seipgsqafl skvqs
//
LOCUS       NP_001394524             384 aa            linear   ROD 09-OCT-2023
DEFINITION  mitogen-activated protein kinase 10 isoform 5 [Mus musculus].
ACCESSION   NP_001394524
VERSION     NP_001394524.1
DBSOURCE    REFSEQ: accession NM_001407595.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 384)
  AUTHORS   Priego M, Noriega L, Kalinin S, Hoffman LM, Feinstein DL and
            Morfini G.
  TITLE     Genetic deletion of c-Jun amino-terminal kinase 3 (JNK3) modestly
            increases disease severity in a mouse model of multiple sclerosis
  JOURNAL   J Neuroimmunol 382, 578152 (2023)
   PUBMED   37454525
  REMARK    GeneRIF: Genetic deletion of c-Jun amino-terminal kinase 3 (JNK3)
            modestly increases disease severity in a mouse model of multiple
            sclerosis.
REFERENCE   2  (residues 1 to 384)
  AUTHORS   Liu F, Deng Y, Zhao Y, Li Z, Gao J, Zhang Y, Yang X, Liu Y and Xia
            Y.
  TITLE     Time series RNA-seq analysis identifies MAPK10 as a critical gene
            in diabetes mellitus-induced atrial fibrillation in mice
  JOURNAL   J Mol Cell Cardiol 168, 70-82 (2022)
   PUBMED   35489387
  REMARK    GeneRIF: Time series RNA-seq analysis identifies MAPK10 as a
            critical gene in diabetes mellitus-induced atrial fibrillation in
            mice.
REFERENCE   3  (residues 1 to 384)
  AUTHORS   Cunningham JG, Scripter JD, Nti SA and Tucker ES.
  TITLE     Early construction of the thalamocortical axon pathway requires
            c-Jun N-terminal kinase signaling within the ventral forebrain
  JOURNAL   Dev Dyn 251 (3), 459-480 (2022)
   PUBMED   34494344
REFERENCE   4  (residues 1 to 384)
  AUTHORS   Goodwani S, Fernandez C, Acton PJ, Buggia-Prevot V, McReynolds ML,
            Ma J, Hu CH, Hamby ME, Jiang Y, Le K, Soth MJ, Jones P and Ray WJ.
  TITLE     Dual Leucine Zipper Kinase Is Constitutively Active in the Adult
            Mouse Brain and Has Both Stress-Induced and Homeostatic Functions
  JOURNAL   Int J Mol Sci 21 (14), 4849 (2020)
   PUBMED   32659913
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 384)
  AUTHORS   Loughran G, Chou MY, Ivanov IP, Jungreis I, Kellis M, Kiran AM,
            Baranov PV and Atkins JF.
  TITLE     Evidence of efficient stop codon readthrough in four mammalian
            genes
  JOURNAL   Nucleic Acids Res 42 (14), 8928-8938 (2014)
   PUBMED   25013167
REFERENCE   6  (residues 1 to 384)
  AUTHORS   Beier H and Grimm M.
  TITLE     Misreading of termination codons in eukaryotes by natural nonsense
            suppressor tRNAs
  JOURNAL   Nucleic Acids Res 29 (23), 4767-4782 (2001)
   PUBMED   11726686
  REMARK    Review article
REFERENCE   7  (residues 1 to 384)
  AUTHORS   Yang DD, Kuan CY, Whitmarsh AJ, Rincon M, Zheng TS, Davis RJ, Rakic
            P and Flavell RA.
  TITLE     Absence of excitotoxicity-induced apoptosis in the hippocampus of
            mice lacking the Jnk3 gene
  JOURNAL   Nature 389 (6653), 865-870 (1997)
   PUBMED   9349820
REFERENCE   8  (residues 1 to 384)
  AUTHORS   Casanova E, Garate C, Ovalle S, Calvo P and Chinchetru MA.
  TITLE     Identification of four splice variants of the mouse
            stress-activated protein kinase JNK/SAPK alpha-isoform
  JOURNAL   Neuroreport 7 (7), 1320-1324 (1996)
   PUBMED   8817558
REFERENCE   9  (residues 1 to 384)
  AUTHORS   Martin JH, Mohit AA and Miller CA.
  TITLE     Developmental expression in the mouse nervous system of the p493F12
            SAP kinase
  JOURNAL   Brain Res Mol Brain Res 35 (1-2), 47-57 (1996)
   PUBMED   8717339
REFERENCE   10 (residues 1 to 384)
  AUTHORS   Suzuki J, Yoshida S, Chen ZL, Momota Y, Kato K, Hirata A and
            Shiosaka S.
  TITLE     Ontogeny of neuropsin mRNA expression in the mouse brain
  JOURNAL   Neurosci Res 23 (4), 345-351 (1995)
   PUBMED   8602273
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC160244.11, AC123664.15,
            AC137121.9 and AC125252.7.
            
            Summary: The protein encoded by this gene is a member of the MAP
            kinase family. MAP kinases act as integration points for multiple
            biochemical signals, and thus are involved in a wide variety of
            cellular processes, such as proliferation, differentiation,
            transcription regulation and development. This kinase is
            specifically expressed in a subset of neurons in the nervous system
            and is activated by threonine and tyrosine phosphorylation.
            Targeted deletion of this gene in mice suggests that it may have a
            role in stress-induced neuronal apoptosis. Alternatively spliced
            transcript variants encoding different isoforms have been found for
            this gene. A recent study provided evidence for translational
            readthrough in this gene, and expression of an additional
            C-terminally extended isoform via the use of an alternative
            in-frame translation termination codon. [provided by RefSeq, Dec
            2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10662772.3481502.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN01164131,
                                           SAMN01164138 [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..384
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 49.61 cM"
     Protein         1..384
                     /product="mitogen-activated protein kinase 10 isoform 5"
                     /EC_number="2.7.11.24"
                     /note="JNK3 beta1 protein kinase; JNK3 beta2 protein
                     kinase; MAP kinase 10; MAP kinase p49 3F12; c-Jun
                     N-terminal kinase 3; stress-activated protein kinase JNK3;
                     SAPK/Erk/kinase 2"
                     /calculated_mol_wt=43966
     Region          25..360
                     /region_name="STKc_JNK"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     c-Jun N-terminal Kinase; cd07850"
                     /db_xref="CDD:270840"
     Site            order(32..38,40,53,55,72,86,108..114,116..117,151,153,
                     155..156,158,168..169,172,183,185..188,190,227)
                     /site_type="active"
                     /db_xref="CDD:270840"
     Site            order(32..38,40,53,55,86,108..114,158,168)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270840"
     Site            order(72,116,151,153,172,183,185..188,190,227)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270840"
     Site            order(112,118,127,130,159..163,323..324,326,329)
                     /site_type="other"
                     /note="KIM docking site [polypeptide binding]"
                     /db_xref="CDD:270840"
     Site            order(168..178,182..190)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270840"
     CDS             1..384
                     /gene="Mapk10"
                     /gene_synonym="C230008H04Rik; JNK3; JNK3B1; JNK3B2;
                     p493F12; p54bSAPK; SAPK(beta); Serk2"
                     /coded_by="NM_001407595.1:543..1697"
                     /note="isoform 5 is encoded by transcript variant 21"
                     /db_xref="GeneID:26414"
                     /db_xref="MGI:MGI:1346863"
ORIGIN      
        1 mskskvdnqf ysvevgdstf tvlkryqnlk pigsgaqgiv caaydavldr nvaikklsrp
       61 fqnqthakra yrelvlmkcv nhkniislln vftpqktlee fqdvylvmel mdanlcqviq
      121 meldhermsy llyqmlcgik hlhsagiihr dlkpsnivvk sdctlkildf glartagtsf
      181 mmtpyvvtry yrapevilgm gykenvdiws vgcimgemvr hkilfpgrdy idqwnkvieq
      241 lgtpcpefmk klqptvrnyv enrpkyaglt fpklfpdslf padsehnklk asqardllsk
      301 mlvidpakri svddalqhpy invwydpaev eapppqiydk qlderehtie ewkeliykev
      361 mnseektkng vvkgqpspsa qvqq
//
LOCUS       NP_001278102             477 aa            linear   ROD 09-OCT-2023
DEFINITION  nuclear factor of activated T-cells, cytoplasmic 2 isoform j [Mus
            musculus].
ACCESSION   NP_001278102
VERSION     NP_001278102.1
DBSOURCE    REFSEQ: accession NM_001291173.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 477)
  AUTHORS   Fu Y, Wang J, Liu C, Liao K, Gao X, Tang R, Fan B, Hong Y, Xiao N,
            Xiao C and Liu WH.
  TITLE     Glycogen synthase kinase 3 controls T-cell exhaustion by regulating
            NFAT activation
  JOURNAL   Cell Mol Immunol 20 (10), 1127-1139 (2023)
   PUBMED   37553428
  REMARK    GeneRIF: Glycogen synthase kinase 3 controls T-cell exhaustion by
            regulating NFAT activation.
REFERENCE   2  (residues 1 to 477)
  AUTHORS   Wan X, Zhao S, Dai Y, Zhang J, Shen Y, Gong L and Le Q.
  TITLE     WNT16b promotes the proliferation and self-renewal of human limbal
            epithelial stem/progenitor cells via activating the
            calcium/calcineurin A/NFATC2 pathway
  JOURNAL   Cell Prolif 56 (10), e13460 (2023)
   PUBMED   36974338
  REMARK    GeneRIF: WNT16b promotes the proliferation and self-renewal of
            human limbal epithelial stem/progenitor cells via activating the
            calcium/calcineurin A/NFATC2 pathway.
REFERENCE   3  (residues 1 to 477)
  AUTHORS   Jiang F, Guo Y, Hu L, Zhang M, Meng J, Si Y and Shi H.
  TITLE     Role of nuclear factor of activated T Cells-1 in Sepsis-induced
            behavioral deficits in mice
  JOURNAL   Brain Res 1806, 148299 (2023)
   PUBMED   36842570
REFERENCE   4  (residues 1 to 477)
  AUTHORS   Nagai J, Lin J and Boyce JA.
  TITLE     Macrophage P2Y6 Receptor Signaling Selectively Activates NFATC2 and
            Suppresses Allergic Lung Inflammation
  JOURNAL   J Immunol 209 (12), 2293-2303 (2022)
   PUBMED   36307120
  REMARK    GeneRIF: Macrophage P2Y6 Receptor Signaling Selectively Activates
            NFATC2 and Suppresses Allergic Lung Inflammation.
REFERENCE   5  (residues 1 to 477)
  AUTHORS   Zhu L, Zhou X, Gu M, Kim J, Li Y, Ko CJ, Xie X, Gao T, Cheng X and
            Sun SC.
  TITLE     Dapl1 controls NFATc2 activation to regulate CD8+ T cell exhaustion
            and responses in chronic infection and cancer
  JOURNAL   Nat Cell Biol 24 (7), 1165-1176 (2022)
   PUBMED   35773432
REFERENCE   6  (residues 1 to 477)
  AUTHORS   Vihma H, Pruunsild P and Timmusk T.
  TITLE     Alternative splicing and expression of human and mouse NFAT genes
  JOURNAL   Genomics 92 (5), 279-291 (2008)
   PUBMED   18675896
REFERENCE   7  (residues 1 to 477)
  AUTHORS   Ho SN, Thomas DJ, Timmerman LA, Li X, Francke U and Crabtree GR.
  TITLE     NFATc3, a lymphoid-specific NFATc family member that is
            calcium-regulated and exhibits distinct DNA binding specificity
  JOURNAL   J Biol Chem 270 (34), 19898-19907 (1995)
   PUBMED   7650004
REFERENCE   8  (residues 1 to 477)
  AUTHORS   Jain J, Burgeon E, Badalian TM, Hogan PG and Rao A.
  TITLE     A similar DNA-binding motif in NFAT family proteins and the Rel
            homology region
  JOURNAL   J Biol Chem 270 (8), 4138-4145 (1995)
   PUBMED   7876165
REFERENCE   9  (residues 1 to 477)
  AUTHORS   Li X, Ho SN, Luna J, Giacalone J, Thomas DJ, Timmerman LA, Crabtree
            GR and Francke U.
  TITLE     Cloning and chromosomal localization of the human and murine genes
            for the T-cell transcription factors NFATc and NFATp
  JOURNAL   Cytogenet Cell Genet 68 (3-4), 185-191 (1995)
   PUBMED   7842733
REFERENCE   10 (residues 1 to 477)
  AUTHORS   Ho AM, Jain J, Rao A and Hogan PG.
  TITLE     Expression of the transcription factor NFATp in a neuronal cell
            line and in the murine nervous system
  JOURNAL   J Biol Chem 269 (45), 28181-28186 (1994)
   PUBMED   7961754
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK044489.1, EU887591.1, EU887585.1 and BP757417.1.
            
            Transcript Variant: This variant (10, also known as
            IA-deltaII-deltaXa) contains alternate 5' exon structure, and it
            thus differs in the 5' UTR and initiates translation at a
            downstream in-frame start codon, compared to variant 1. The encoded
            isoform (j) is shorter at the N-terminus, compared to isoform a.
            Both variants 10 and 15 encode isoform j.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU887591.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 88.91 cM"
     Protein         1..477
                     /product="nuclear factor of activated T-cells, cytoplasmic
                     2 isoform j"
                     /note="nuclear factor of activated T-cells, cytoplasmic 2;
                     NFAT pre-existing subunit; T-cell transcription factor
                     NFAT1"
                     /calculated_mol_wt=52558
     Region          <1..124
                     /region_name="RHD-n"
                     /note="N-terminal sub-domain of the Rel homology domain
                     (RHD); cl08275"
                     /db_xref="CDD:447596"
     Region          129..229
                     /region_name="IPT_NFAT"
                     /note="IPT domain of the NFAT family of transcription
                     factors. NFAT transcription complexes are a target of
                     calcineurin, a calcium dependent phosphatase, and activate
                     genes mainly involved in cell-cell-interaction; cd01178"
                     /db_xref="CDD:238583"
     Site            order(153,217)
                     /site_type="DNA binding"
                     /note="DNA binding sites [nucleotide binding]"
                     /db_xref="CDD:238583"
     CDS             1..477
                     /gene="Nfatc2"
                     /gene_synonym="NF-ATc2; NF-ATp; NFAT1; NFAT1-D; Nfatp"
                     /coded_by="NM_001291173.1:374..1807"
                     /note="isoform j is encoded by transcript variant 10"
                     /db_xref="GeneID:18019"
                     /db_xref="MGI:MGI:102463"
ORIGIN      
        1 menkplglqi figtaderil kphafyqvhr itgktvttts yekivgntkv leiplepknn
       61 mratidcagi lklrnadiel rkgetdigrk ntrvrlvfrv hvpepsgriv slqaasnpie
      121 csqrsahelp mverqdmdsc lvyggqqmil tgqnftaesk vvfmekttdg qqiwemeatv
      181 dkdksqpnml fveipeyrnk hirvpvkvnf yvingkrkrs qpqhftyhpv paiktepsde
      241 yepslicspa hgglgsqpyy pqhpmlaesp sclvatmapc qqfrsglssp daryqqqspa
      301 aalyqrsksl spgllgyqqp sllaaplgla dahrsvlvha gsqgqgqgst lphtssasqq
      361 aspvihyspt nqqlrggghq efqhimycen fgpssarpgp ppinqgqrls pgayptviqq
      421 qtapsqraak ngpsdqkeal ptgvtvkqeq nldqtylddv neiirkefsg ppsrnqt
//
LOCUS       NP_001396828             147 aa            linear   ROD 09-OCT-2023
DEFINITION  allograft inflammatory factor 1 isoform a [Mus musculus].
ACCESSION   NP_001396828 XP_006523566
VERSION     NP_001396828.1
DBSOURCE    REFSEQ: accession NM_001409899.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 147)
  AUTHORS   Altounian M, Bellon A and Mann F.
  TITLE     Neuronal miR-17-5p contributes to interhemispheric cortical
            connectivity defects induced by prenatal alcohol exposure
  JOURNAL   Cell Rep 42 (9), 113020 (2023)
   PUBMED   37610874
REFERENCE   2  (residues 1 to 147)
  AUTHORS   Rodriguez-Lopez A, Torres-Paniagua AM, Acero G, Diaz G and
            Gevorkian G.
  TITLE     Increased TSPO expression, pyroglutamate-modified amyloid beta
            (AbetaN3(pE)) accumulation and transient clustering of microglia in
            the thalamus of Tg-SwDI mice
  JOURNAL   J Neuroimmunol 382, 578150 (2023)
   PUBMED   37467699
  REMARK    GeneRIF: Increased TSPO expression, pyroglutamate-modified amyloid
            beta (AbetaN3(pE)) accumulation and transient clustering of
            microglia in the thalamus of Tg-SwDI mice.
REFERENCE   3  (residues 1 to 147)
  AUTHORS   Cao B, Xia Y, Cai Z, Wang Z, Tang C and Song Y.
  TITLE     Construction of a Brain-specific SLC23A2 Gene Knockout Mice Model
  JOURNAL   Neuroscience 524, 137-148 (2023)
   PUBMED   37330196
REFERENCE   4  (residues 1 to 147)
  AUTHORS   Meng H, Zhao Y, Li Y, Fan H, Yi X, Meng X, Wang P, Fu F, Wu S and
            Wang Y.
  TITLE     Evidence for developmental vascular-associated necroptosis and its
            contribution to venous-lymphatic endothelial differentiation
  JOURNAL   Front Cell Dev Biol 11, 1229788 (2023)
   PUBMED   37576598
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 147)
  AUTHORS   Waldhauser V, Baroti T, Frob F and Wegner M.
  TITLE     PBAF Subunit Pbrm1 Selectively Influences the Transition from
            Progenitors to Pre-Myelinating Cells during Oligodendrocyte
            Development
  JOURNAL   Cells 12 (12), 1556 (2023)
   PUBMED   37371026
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 147)
  AUTHORS   Sasaki Y, Ohsawa K, Kanazawa H, Kohsaka S and Imai Y.
  TITLE     Iba1 is an actin-cross-linking protein in macrophages/microglia
  JOURNAL   Biochem Biophys Res Commun 286 (2), 292-297 (2001)
   PUBMED   11500035
REFERENCE   7  (residues 1 to 147)
  AUTHORS   Ohsawa K, Imai Y, Kanazawa H, Sasaki Y and Kohsaka S.
  TITLE     Involvement of Iba1 in membrane ruffling and phagocytosis of
            macrophages/microglia
  JOURNAL   J Cell Sci 113 (Pt 17), 3073-3084 (2000)
   PUBMED   10934045
REFERENCE   8  (residues 1 to 147)
  AUTHORS   Allcock RJ, Martin AM and Price P.
  TITLE     The mouse as a model for the effects of MHC genes on human disease
  JOURNAL   Immunol Today 21 (7), 328-332 (2000)
   PUBMED   10871872
  REMARK    Review article
REFERENCE   9  (residues 1 to 147)
  AUTHORS   Handel-Fernandez ME, Kurimoto I, Streilein JW and Vincek V.
  TITLE     Genetic mapping and physical cloning of UVB susceptibility region
            in mice
  JOURNAL   J Invest Dermatol 113 (2), 224-229 (1999)
   PUBMED   10469308
REFERENCE   10 (residues 1 to 147)
  AUTHORS   Lund T, Shaikh S, Kendall E, Campbell RD, Hattori M, Makino S and
            Cooke A.
  TITLE     RFLP analysis of the MHC class III region defines unique haplotypes
            for the non-obese diabetic, cataract Shionogi and the non-obese
            non-diabetic mouse strains
  JOURNAL   Diabetologia 36 (8), 727-733 (1993)
   PUBMED   8104833
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CR974444.18.
            
            On Jul 25, 2022 this sequence version replaced XP_006523566.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189685.277632.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..147
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.59 cM"
     Protein         1..147
                     /product="allograft inflammatory factor 1 isoform a"
                     /note="testis specific; ionized calcium binding adapter
                     molecule 1"
                     /calculated_mol_wt=16779
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylserine.
                     /evidence=ECO:0000250|UniProtKB:P81076; propagated from
                     UniProtKB/Swiss-Prot (O70200.1)"
     Site            11
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P55008; propagated from
                     UniProtKB/Swiss-Prot (O70200.1)"
     Region          <48..113
                     /region_name="PTZ00184"
                     /note="calmodulin; Provisional"
                     /db_xref="CDD:185504"
     Region          128..147
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O70200.1)"
     CDS             1..147
                     /gene="Aif1"
                     /gene_synonym="AIF-1; D17H6S50E; G1; Iba1"
                     /coded_by="NM_001409899.1:386..829"
                     /note="isoform a is encoded by transcript variant 4"
                     /db_xref="GeneID:11629"
                     /db_xref="MGI:MGI:1343098"
ORIGIN      
        1 msqsrdlqgg kafgllkaqq eerleginkq flddpkysnd edlpskleaf kvkymefdln
       61 gngdidimsl krmleklgvp kthlelkrli revssgseet fsysdflrmm lgkrsailrm
      121 ilmyeeknke hkrptgppak kaiselp
//
LOCUS       NP_035029                927 aa            linear   ROD 09-OCT-2023
DEFINITION  nuclear factor of activated T-cells, cytoplasmic 2 isoform a [Mus
            musculus].
ACCESSION   NP_035029
VERSION     NP_035029.2
DBSOURCE    REFSEQ: accession NM_010899.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 927)
  AUTHORS   Fu Y, Wang J, Liu C, Liao K, Gao X, Tang R, Fan B, Hong Y, Xiao N,
            Xiao C and Liu WH.
  TITLE     Glycogen synthase kinase 3 controls T-cell exhaustion by regulating
            NFAT activation
  JOURNAL   Cell Mol Immunol 20 (10), 1127-1139 (2023)
   PUBMED   37553428
  REMARK    GeneRIF: Glycogen synthase kinase 3 controls T-cell exhaustion by
            regulating NFAT activation.
REFERENCE   2  (residues 1 to 927)
  AUTHORS   Wan X, Zhao S, Dai Y, Zhang J, Shen Y, Gong L and Le Q.
  TITLE     WNT16b promotes the proliferation and self-renewal of human limbal
            epithelial stem/progenitor cells via activating the
            calcium/calcineurin A/NFATC2 pathway
  JOURNAL   Cell Prolif 56 (10), e13460 (2023)
   PUBMED   36974338
  REMARK    GeneRIF: WNT16b promotes the proliferation and self-renewal of
            human limbal epithelial stem/progenitor cells via activating the
            calcium/calcineurin A/NFATC2 pathway.
REFERENCE   3  (residues 1 to 927)
  AUTHORS   Jiang F, Guo Y, Hu L, Zhang M, Meng J, Si Y and Shi H.
  TITLE     Role of nuclear factor of activated T Cells-1 in Sepsis-induced
            behavioral deficits in mice
  JOURNAL   Brain Res 1806, 148299 (2023)
   PUBMED   36842570
REFERENCE   4  (residues 1 to 927)
  AUTHORS   Nagai J, Lin J and Boyce JA.
  TITLE     Macrophage P2Y6 Receptor Signaling Selectively Activates NFATC2 and
            Suppresses Allergic Lung Inflammation
  JOURNAL   J Immunol 209 (12), 2293-2303 (2022)
   PUBMED   36307120
  REMARK    GeneRIF: Macrophage P2Y6 Receptor Signaling Selectively Activates
            NFATC2 and Suppresses Allergic Lung Inflammation.
REFERENCE   5  (residues 1 to 927)
  AUTHORS   Zhu L, Zhou X, Gu M, Kim J, Li Y, Ko CJ, Xie X, Gao T, Cheng X and
            Sun SC.
  TITLE     Dapl1 controls NFATc2 activation to regulate CD8+ T cell exhaustion
            and responses in chronic infection and cancer
  JOURNAL   Nat Cell Biol 24 (7), 1165-1176 (2022)
   PUBMED   35773432
REFERENCE   6  (residues 1 to 927)
  AUTHORS   Vihma H, Pruunsild P and Timmusk T.
  TITLE     Alternative splicing and expression of human and mouse NFAT genes
  JOURNAL   Genomics 92 (5), 279-291 (2008)
   PUBMED   18675896
REFERENCE   7  (residues 1 to 927)
  AUTHORS   Ho SN, Thomas DJ, Timmerman LA, Li X, Francke U and Crabtree GR.
  TITLE     NFATc3, a lymphoid-specific NFATc family member that is
            calcium-regulated and exhibits distinct DNA binding specificity
  JOURNAL   J Biol Chem 270 (34), 19898-19907 (1995)
   PUBMED   7650004
REFERENCE   8  (residues 1 to 927)
  AUTHORS   Jain J, Burgeon E, Badalian TM, Hogan PG and Rao A.
  TITLE     A similar DNA-binding motif in NFAT family proteins and the Rel
            homology region
  JOURNAL   J Biol Chem 270 (8), 4138-4145 (1995)
   PUBMED   7876165
REFERENCE   9  (residues 1 to 927)
  AUTHORS   Li X, Ho SN, Luna J, Giacalone J, Thomas DJ, Timmerman LA, Crabtree
            GR and Francke U.
  TITLE     Cloning and chromosomal localization of the human and murine genes
            for the T-cell transcription factors NFATc and NFATp
  JOURNAL   Cytogenet Cell Genet 68 (3-4), 185-191 (1995)
   PUBMED   7842733
REFERENCE   10 (residues 1 to 927)
  AUTHORS   Ho AM, Jain J, Rao A and Hogan PG.
  TITLE     Expression of the transcription factor NFATp in a neuronal cell
            line and in the murine nervous system
  JOURNAL   J Biol Chem 269 (45), 28181-28186 (1994)
   PUBMED   7961754
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK135414.1, EU887588.1, EU887581.1 and BP757417.1.
            
            On Nov 10, 2005 this sequence version replaced NP_035029.1.
            
            Transcript Variant: This variant (1, also known as IB-IIL-deltaXa)
            encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U36576.1, EU887588.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..927
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 88.91 cM"
     Protein         1..927
                     /product="nuclear factor of activated T-cells, cytoplasmic
                     2 isoform a"
                     /note="nuclear factor of activated T-cells, cytoplasmic 2;
                     NFAT pre-existing subunit; T-cell transcription factor
                     NFAT1"
                     /calculated_mol_wt=99889
     Region          400..574
                     /region_name="RHD-n_NFAT"
                     /note="N-terminal sub-domain of the Rel homology domain
                     (RHD) of nuclear factor of activated T-cells (NFAT)
                     proteins; cd07881"
                     /db_xref="CDD:143641"
     Site            order(423,426,428..429,431..433,481,522,524..525,539..540,
                     542,573)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143641"
     Region          579..679
                     /region_name="IPT_NFAT"
                     /note="IPT domain of the NFAT family of transcription
                     factors. NFAT transcription complexes are a target of
                     calcineurin, a calcium dependent phosphatase, and activate
                     genes mainly involved in cell-cell-interaction; cd01178"
                     /db_xref="CDD:238583"
     Site            order(603,667)
                     /site_type="DNA binding"
                     /note="DNA binding sites [nucleotide binding]"
                     /db_xref="CDD:238583"
     CDS             1..927
                     /gene="Nfatc2"
                     /gene_synonym="NF-ATc2; NF-ATp; NFAT1; NFAT1-D; Nfatp"
                     /coded_by="NM_010899.3:175..2958"
                     /note="isoform a is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS17112.1"
                     /db_xref="GeneID:18019"
                     /db_xref="MGI:MGI:102463"
ORIGIN      
        1 mdvpepqpdp dggdgpghep ggspqdeldf silfdydyln pieeepiahk aisspsglay
       61 pddvldyglk pcnplaslsg eppgrfgepd sigfqnflsp vkpagasgps prieitpshe
      121 lmqaggalrg rdaglspeqp alalagvaas prftlpvpgy egyreplcls passgssasf
      181 isdtfspyts pcvspnnagp ddlcpqfqni pahysprtsp imsprtslae dsclgrhspv
      241 prpasrsssp gakrrhscae alvaplpaas pqrsrspspq psphvalqdd sipagyppta
      301 gsavlmdaln tlatdspcgi pskiwktspd ptpvstapsk aglarhiypt veflgpceqe
      361 errnsapesi llvpptwpkq lvpaipicsi pvtaslpple wplsnqsgsy elrievqpkp
      421 hhrahyeteg srgavkaptg ghpvvqlhgy menkplglqi figtaderil kphafyqvhr
      481 itgktvttts yekivgntkv leiplepknn mratidcagi lklrnadiel rkgetdigrk
      541 ntrvrlvfrv hvpepsgriv slqaasnpie csqrsahelp mverqdmdsc lvyggqqmil
      601 tgqnftaesk vvfmekttdg qqiwemeatv dkdksqpnml fveipeyrnk hirvpvkvnf
      661 yvingkrkrs qpqhftyhpv paiktepsde yepslicspa hgglgsqpyy pqhpmlaesp
      721 sclvatmapc qqfrsglssp daryqqqspa aalyqrsksl spgllgyqqp sllaaplgla
      781 dahrsvlvha gsqgqgqgst lphtssasqq aspvihyspt nqqlrggghq efqhimycen
      841 fgpssarpgp ppinqgqrls pgayptviqq qtapsqraak ngpsdqkeal ptgvtvkqeq
      901 nldqtylddv neiirkefsg ppsrnqt
//
LOCUS       NP_001351567             361 aa            linear   ROD 09-OCT-2023
DEFINITION  RNA-binding protein Nova-1 isoform 5 [Mus musculus].
ACCESSION   NP_001351567 XP_017170648
VERSION     NP_001351567.1
DBSOURCE    REFSEQ: accession NM_001364638.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 361)
  AUTHORS   Tajima Y, Ito K, Yuan Y, Frank MO, Saito Y and Darnell RB.
  TITLE     NOVA1 acts on Impact to regulate hypothalamic function and
            translation in inhibitory neurons
  JOURNAL   Cell Rep 42 (2), 112050 (2023)
   PUBMED   36716149
  REMARK    GeneRIF: NOVA1 acts on Impact to regulate hypothalamic function and
            translation in inhibitory neurons.
REFERENCE   2  (residues 1 to 361)
  AUTHORS   Brahma MK, Xiao P, Popa M, Negueruela J, Vandenbempt V, Demine S,
            Cardozo AK and Gurzov EN.
  TITLE     Nova1 or Bim Deficiency in Pancreatic beta-Cells Does Not Alter
            Multiple Low-Dose Streptozotocin-Induced Diabetes and Diet-Induced
            Obesity in Mice
  JOURNAL   Nutrients 14 (18), 3866 (2022)
   PUBMED   36145242
  REMARK    GeneRIF: Nova1 or Bim Deficiency in Pancreatic beta-Cells Does Not
            Alter Multiple Low-Dose Streptozotocin-Induced Diabetes and
            Diet-Induced Obesity in Mice.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 361)
  AUTHORS   Krach F, Wheeler EC, Regensburger M, Boerstler T, Wend H, Vu AQ,
            Wang R, Reischl S, Boldt K, Batra R, Aigner S, Ravits J, Winkler J,
            Yeo GW and Winner B.
  TITLE     Aberrant NOVA1 function disrupts alternative splicing in early
            stages of amyotrophic lateral sclerosis
  JOURNAL   Acta Neuropathol 144 (3), 413-435 (2022)
   PUBMED   35778567
  REMARK    GeneRIF: Aberrant NOVA1 function disrupts alternative splicing in
            early stages of amyotrophic lateral sclerosis.
REFERENCE   4  (residues 1 to 361)
  AUTHORS   Li D, Shen M, Deng X and Bai Y.
  TITLE     MicroRNA miR-27a-3p accelerates cardiac hypertrophy by targeting
            neuro-oncological ventral antigen 1
  JOURNAL   Bioengineered 13 (4), 8982-8993 (2022)
   PUBMED   35348441
  REMARK    GeneRIF: MicroRNA miR-27a-3p accelerates cardiac hypertrophy by
            targeting neuro-oncological ventral antigen 1.
REFERENCE   5  (residues 1 to 361)
  AUTHORS   Johnson V, Junge HJ and Chen Z.
  TITLE     Temporal regulation of axonal repulsion by alternative splicing of
            a conserved microexon in mammalian Robo1 and Robo2
  JOURNAL   Elife 8, e46042 (2019)
   PUBMED   31392959
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 361)
  AUTHORS   Jensen KB, Dredge BK, Stefani G, Zhong R, Buckanovich RJ, Okano HJ,
            Yang YY and Darnell RB.
  TITLE     Nova-1 regulates neuron-specific alternative splicing and is
            essential for neuronal viability
  JOURNAL   Neuron 25 (2), 359-371 (2000)
   PUBMED   10719891
REFERENCE   7  (residues 1 to 361)
  AUTHORS   Yang YY, Yin GL and Darnell RB.
  TITLE     The neuronal RNA-binding protein Nova-2 is implicated as the
            autoantigen targeted in POMA patients with dementia
  JOURNAL   Proc Natl Acad Sci U S A 95 (22), 13254-13259 (1998)
   PUBMED   9789075
REFERENCE   8  (residues 1 to 361)
  AUTHORS   Fletcher CF, Okano HJ, Gilbert DJ, Yang Y, Yang C, Copeland NG,
            Jenkins NA and Darnell RB.
  TITLE     Mouse chromosomal locations of nine genes encoding homologs of
            human paraneoplastic neurologic disorder antigens
  JOURNAL   Genomics 45 (2), 313-319 (1997)
   PUBMED   9344654
REFERENCE   9  (residues 1 to 361)
  AUTHORS   Buckanovich RJ and Darnell RB.
  TITLE     The neuronal RNA binding protein Nova-1 recognizes specific RNA
            targets in vitro and in vivo
  JOURNAL   Mol Cell Biol 17 (6), 3194-3201 (1997)
   PUBMED   9154818
REFERENCE   10 (residues 1 to 361)
  AUTHORS   Buckanovich RJ, Yang YY and Darnell RB.
  TITLE     The onconeural antigen Nova-1 is a neuron-specific RNA-binding
            protein, the activity of which is inhibited by paraneoplastic
            antibodies
  JOURNAL   J Neurosci 16 (3), 1114-1122 (1996)
   PUBMED   8558240
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156636.2, AC108802.15 and CT009504.11.
            
            On Jun 26, 2018 this sequence version replaced XP_017170648.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660821.165374.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..361
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 21.46 cM"
     Protein         1..361
                     /product="RNA-binding protein Nova-1 isoform 5"
                     /note="RNA-binding protein Nova-1; ventral neuron-specific
                     protein 1; neuro-oncological ventral antigen 1"
                     /calculated_mol_wt=36119
     Region          26..95
                     /region_name="KH-I_NOVA_rpt2"
                     /note="second type I K homology (KH) RNA-binding domain
                     found in the family of neuro-oncological ventral antigen
                     (Nova); cd22436"
                     /db_xref="CDD:411864"
     Site            order(37..39,41..45,48..49,59..61,63..65,73)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:411864"
     Region          276..346
                     /region_name="KH-I_NOVA_rpt3"
                     /note="third type I K homology (KH) RNA-binding domain
                     found in the family of neuro-oncological ventral antigen
                     (Nova); cd09031"
                     /db_xref="CDD:411807"
     Site            order(284..285,287..289,291..295,298..299,309..315,317,
                     322,324)
                     /site_type="other"
                     /note="RNA binding site [nucleotide binding]"
                     /db_xref="CDD:411807"
     CDS             1..361
                     /gene="Nova1"
                     /gene_synonym="9430099M15Rik; G630039L02; Nova-1"
                     /coded_by="NM_001364638.1:485..1570"
                     /note="isoform 5 is encoded by transcript variant 6"
                     /db_xref="GeneID:664883"
                     /db_xref="MGI:MGI:104297"
ORIGIN      
        1 mpqnvaktep vsilqpqttv npdrikqvki ivpnstagli igkggatvka imeqsgawvq
       61 lsqkpdginl qervvtvsge peqnrkavel iiqkiqedpq sgsclnisya nvtgpvansn
      121 ptgspyanta evlptaaaaa gllghanlag vaafpavlsg ftgndlvait salntlasyg
      181 ynlntlglgl sqaaatgala aaaasanpaa aaanllatya seasasgsta ggtagtfalg
      241 slaaataatn gyfgaaspla asailgteks tdgskdvvei avpenlvgai lgkggktlve
      301 yqeltgariq iskkgefvpg trnrkvtitg tpaatqaaqy litqrityeq gvraanpqkv
      361 g
//
LOCUS       NP_001157698             503 aa            linear   ROD 09-OCT-2023
DEFINITION  nuclear respiratory factor 1 isoform a [Mus musculus].
ACCESSION   NP_001157698
VERSION     NP_001157698.1
DBSOURCE    REFSEQ: accession NM_001164226.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 503)
  AUTHORS   Cheng C, Tian Y, Yang R, Guo W, Xiao K, Zhang F, Tian J, Deng Z,
            Yang W, Yang H and Zhou Z.
  TITLE     miR-5581 Contributes to Osteoarthritis by Targeting NRF1 to Disturb
            the Proliferation and Functions of Chondrocytes
  JOURNAL   Am J Pathol 193 (9), 1234-1247 (2023)
   PUBMED   37611970
  REMARK    GeneRIF: miR-5581 Contributes to Osteoarthritis by Targeting NRF1
            to Disturb the Proliferation and Functions of Chondrocytes.
REFERENCE   2  (residues 1 to 503)
  AUTHORS   Meng Z, Liang B, Wu Y, Liu C, Wang H, Du Y, Gan L, Gao E, Lau WB,
            Christopher TA, Lopez BL, Koch WJ, Ma X, Zhao F, Wang Y and Zhao J.
  TITLE     Hypoadiponectinemia-induced upregulation of microRNA449b
            downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury
            in diabetic mice
  JOURNAL   J Mol Cell Cardiol 182, 1-14 (2023)
   PUBMED   37437402
  REMARK    GeneRIF: Hypoadiponectinemia-induced upregulation of microRNA449b
            downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury
            in diabetic mice.
REFERENCE   3  (residues 1 to 503)
  AUTHORS   Zhao T, Zhang J, Lei H, Meng Y, Cheng H, Zhao Y, Geng G, Mu C, Chen
            L, Liu Q, Luo Q, Zhang C, Long Y, Su J, Wang Y, Li Z, Sun J, Chen
            G, Li Y, Liao X, Shang Y, Hu G, Chen Q and Zhu Y.
  TITLE     NRF1-mediated mitochondrial biogenesis antagonizes innate antiviral
            immunity
  JOURNAL   EMBO J 42 (16), e113258 (2023)
   PUBMED   37409632
  REMARK    GeneRIF: NRF1-mediated mitochondrial biogenesis antagonizes innate
            antiviral immunity.
REFERENCE   4  (residues 1 to 503)
  AUTHORS   Akl MG, Baccetto R, Stebbings BM, Li L and Widenmaier SB.
  TITLE     Euglycemia is affected by stress defense factor hepatocyte NRF1,
            but not NRF2
  JOURNAL   Biochem Biophys Res Commun 668, 96-103 (2023)
   PUBMED   37245295
  REMARK    GeneRIF: Euglycemia is affected by stress defense factor hepatocyte
            NRF1, but not NRF2.
REFERENCE   5  (residues 1 to 503)
  AUTHORS   Akl MG, Li L, Baccetto R, Phanse S, Zhang Q, Trites MJ, McDonald S,
            Aoki H, Babu M and Widenmaier SB.
  TITLE     Complementary gene regulation by NRF1 and NRF2 protects against
            hepatic cholesterol overload
  JOURNAL   Cell Rep 42 (4), 112399 (2023)
   PUBMED   37060561
  REMARK    GeneRIF: Complementary gene regulation by NRF1 and NRF2 protects
            against hepatic cholesterol overload.
            Erratum:[Cell Rep. 2023 Jul 25;42(7):112872. PMID: 37454293]
REFERENCE   6  (residues 1 to 503)
  AUTHORS   Carmona MC, Iglesias R, Obregon MJ, Darlington GJ, Villarroya F and
            Giralt M.
  TITLE     Mitochondrial biogenesis and thyroid status maturation in brown fat
            require CCAAT/enhancer-binding protein alpha
  JOURNAL   J Biol Chem 277 (24), 21489-21498 (2002)
   PUBMED   11940593
REFERENCE   7  (residues 1 to 503)
  AUTHORS   Huo L and Scarpulla RC.
  TITLE     Mitochondrial DNA instability and peri-implantation lethality
            associated with targeted disruption of nuclear respiratory factor 1
            in mice
  JOURNAL   Mol Cell Biol 21 (2), 644-654 (2001)
   PUBMED   11134350
REFERENCE   8  (residues 1 to 503)
  AUTHORS   Schaefer L, Engman H and Miller JB.
  TITLE     Coding sequence, chromosomal localization, and expression pattern
            of Nrf1: the mouse homolog of Drosophila erect wing
  JOURNAL   Mamm Genome 11 (2), 104-110 (2000)
   PUBMED   10656923
REFERENCE   9  (residues 1 to 503)
  AUTHORS   Huo L and Scarpulla RC.
  TITLE     Multiple 5'-untranslated exons in the nuclear respiratory factor 1
            gene span 47 kb and contribute to transcript heterogeneity and
            translational efficiency
  JOURNAL   Gene 233 (1-2), 213-224 (1999)
   PUBMED   10375638
REFERENCE   10 (residues 1 to 503)
  AUTHORS   Virbasius CA, Virbasius JV and Scarpulla RC.
  TITLE     NRF-1, an activator involved in nuclear-mitochondrial interactions,
            utilizes a new DNA-binding domain conserved in a family of
            developmental regulators
  JOURNAL   Genes Dev 7 (12A), 2431-2445 (1993)
   PUBMED   8253388
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134897.4 and AC153632.2.
            
            Transcript Variant: This variant (1) encodes isoform a. Variants 1,
            6, 9, and 10 all encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219382.230285.1,
                                           SRR13422598.1912866.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 12.47 cM"
     Protein         1..503
                     /product="nuclear respiratory factor 1 isoform a"
                     /note="NRF-1; alpha-pal; alpha palindromic-binding
                     protein"
                     /calculated_mol_wt=53440
     Region          1..78
                     /region_name="Dimerization. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU00.2)"
     Region          36..57
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU00.2)"
     Site            39
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:Q16656; propagated from
                     UniProtKB/Swiss-Prot (Q9WU00.2)"
     Site            44
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:Q16656; propagated from
                     UniProtKB/Swiss-Prot (Q9WU00.2)"
     Site            46
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:Q16656; propagated from
                     UniProtKB/Swiss-Prot (Q9WU00.2)"
     Site            47
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:Q16656; propagated from
                     UniProtKB/Swiss-Prot (Q9WU00.2)"
     Site            52
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000250|UniProtKB:Q16656; propagated from
                     UniProtKB/Swiss-Prot (Q9WU00.2)"
     Region          87..283
                     /region_name="Nrf1_DNA-bind"
                     /note="NLS-binding and DNA-binding and dimerization
                     domains of Nrf1; pfam10491"
                     /db_xref="CDD:402218"
     Region          88..116
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU00.2)"
     Region          301..476
                     /region_name="Required for transcriptional activation.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU00.2)"
     Region          450..502
                     /region_name="Nrf1_activ_bdg"
                     /note="Nrf1 activator activation site binding domain;
                     pfam10492"
                     /db_xref="CDD:431313"
     CDS             1..503
                     /gene="Nrf1"
                     /gene_synonym="D6Ertd415e"
                     /coded_by="NM_001164226.2:274..1785"
                     /note="isoform a is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS19968.1"
                     /db_xref="GeneID:18181"
                     /db_xref="MGI:MGI:1332235"
ORIGIN      
        1 meehgvtqte hmatieahav aqqvqqvhva tytehsmlsa dedspssped tsyddsdiln
       61 staadevtah laaagpvgma aaaavatgkk rkrphvfesn psirkrqqtr llrklratld
      121 eyttrvgqqa ivlcispskp npvfkvfgaa plenvvrkyk smiledlesa laehapapqe
      181 vnselpplti dgipvsvdkm tqaqlrafip emlkystgrg kpgwgkesck piwwpedipw
      241 anvrsdvrte eqkqrvswtq alrtivkncy kqhgredlly afedqqtqtq attthsiahl
      301 vpsqtvvqtf snpdgtvsli qvgtgatvat ladaselptt vtvaqvnysa vadgeveqnw
      361 atlqggemti qttqaseatq avaslaeaav aasqemqqga tvtmalnsea aahavatlae
      421 atlqgggqiv lsgetaaavg altgvqdang lvqipvsmyq tvvtslaqgn gpvqvamapv
      481 ttrisdsavt mdgqavevvt leq
//
LOCUS       NP_077169                251 aa            linear   ROD 09-OCT-2023
DEFINITION  derlin-1 [Mus musculus].
ACCESSION   NP_077169
VERSION     NP_077169.1
DBSOURCE    REFSEQ: accession NM_024207.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 251)
  AUTHORS   You H, Wen X, Wang X, Zhu C, Chen H, Bu L, Zhang J and Qu S.
  TITLE     Derlin-1 ameliorates nonalcoholic hepatic steatosis by promoting
            ubiquitylation and degradation of FABP1
  JOURNAL   Free Radic Biol Med 207, 260-271 (2023)
   PUBMED   37499886
  REMARK    GeneRIF: Derlin-1 ameliorates nonalcoholic hepatic steatosis by
            promoting ubiquitylation and degradation of FABP1.
REFERENCE   2  (residues 1 to 251)
  AUTHORS   Sugiyama T, Murao N, Kadowaki H and Nishitoh H.
  TITLE     Chemical chaperones ameliorate neurodegenerative disorders in
            Derlin-1-deficient mice via improvement of cholesterol biosynthesis
  JOURNAL   Sci Rep 12 (1), 21840 (2022)
   PUBMED   36528738
  REMARK    GeneRIF: Chemical chaperones ameliorate neurodegenerative disorders
            in Derlin-1-deficient mice via improvement of cholesterol
            biosynthesis.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 251)
  AUTHORS   Sugiyama T, Murao N, Kadowaki H, Takao K, Miyakawa T, Matsushita Y,
            Katagiri T, Futatsugi A, Shinmyo Y, Kawasaki H, Sakai J, Shiomi K,
            Nakazato M, Takeda K, Mikoshiba K, Ploegh HL, Ichijo H and Nishitoh
            H.
  TITLE     ERAD components Derlin-1 and Derlin-2 are essential for postnatal
            brain development and motor function
  JOURNAL   iScience 24 (7), 102758 (2021)
   PUBMED   34355142
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 251)
  AUTHORS   Eura Y, Miyata T and Kokame K.
  TITLE     Derlin-3 Is Required for Changes in ERAD Complex Formation under ER
            Stress
  JOURNAL   Int J Mol Sci 21 (17), 6146 (2020)
   PUBMED   32858914
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 251)
  AUTHORS   Zhang X, Ge Y, Bukhari AA, Zhu Q, Shen Y, Li M, Sun H, Su D and
            Liang X.
  TITLE     Estrogen negatively regulates the renal epithelial sodium channel
            (ENaC) by promoting Derlin-1 expression and AMPK activation
  JOURNAL   Exp Mol Med 51 (5), 1-12 (2019)
   PUBMED   31113930
  REMARK    GeneRIF: Estrogen treatment decreased alpha-ENaC expression but
            increased derlin-1 expression in mouse renal collecting duct
            (mpkCCDc14) cells.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 251)
  AUTHORS   Oda Y, Okada T, Yoshida H, Kaufman RJ, Nagata K and Mori K.
  TITLE     Derlin-2 and Derlin-3 are regulated by the mammalian unfolded
            protein response and are required for ER-associated degradation
  JOURNAL   J Cell Biol 172 (3), 383-393 (2006)
   PUBMED   16449189
REFERENCE   7  (residues 1 to 251)
  AUTHORS   Lilley BN and Ploegh HL.
  TITLE     Multiprotein complexes that link dislocation, ubiquitination, and
            extraction of misfolded proteins from the endoplasmic reticulum
            membrane
  JOURNAL   Proc Natl Acad Sci U S A 102 (40), 14296-14301 (2005)
   PUBMED   16186509
REFERENCE   8  (residues 1 to 251)
  AUTHORS   Katiyar S, Joshi S and Lennarz WJ.
  TITLE     The retrotranslocation protein Derlin-1 binds peptide:N-glycanase
            to the endoplasmic reticulum
  JOURNAL   Mol Biol Cell 16 (10), 4584-4594 (2005)
   PUBMED   16055502
REFERENCE   9  (residues 1 to 251)
  AUTHORS   Ye Y, Shibata Y, Yun C, Ron D and Rapoport TA.
  TITLE     A membrane protein complex mediates retro-translocation from the ER
            lumen into the cytosol
  JOURNAL   Nature 429 (6994), 841-847 (2004)
   PUBMED   15215856
REFERENCE   10 (residues 1 to 251)
  AUTHORS   Lilley BN and Ploegh HL.
  TITLE     A membrane protein required for dislocation of misfolded proteins
            from the ER
  JOURNAL   Nature 429 (6994), 834-840 (2004)
   PUBMED   15215855
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC154874.9.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK043420.1, BC085490.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164140, SAMN02415138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..251
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 24.06 cM"
     Protein         1..251
                     /product="derlin-1"
                     /note="der1-like protein 1; degradation in endoplasmic
                     reticulum protein 1"
                     /calculated_mol_wt=28704
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylserine.
                     /evidence=ECO:0000250|UniProtKB:Q9BUN8; propagated from
                     UniProtKB/Swiss-Prot (Q99J56.1)"
     Region          11..204
                     /region_name="DER1"
                     /note="Der1-like family; pfam04511"
                     /db_xref="CDD:427988"
     Site            16..31
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99J56.1)"
     Site            70..89
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99J56.1)"
     Site            95..115
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99J56.1)"
     Site            123..137
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99J56.1)"
     Site            155..166
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99J56.1)"
     Site            171..189
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99J56.1)"
     Site            201
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q99J56.1)"
     Site            202
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9BUN8; propagated from
                     UniProtKB/Swiss-Prot (Q99J56.1)"
     Site            226
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9BUN8; propagated from
                     UniProtKB/Swiss-Prot (Q99J56.1)"
     Region          229..251
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99J56.1)"
     Region          241..248
                     /region_name="SHP-box.
                     /evidence=ECO:0000250|UniProtKB:Q9BUN8"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99J56.1)"
     CDS             1..251
                     /gene="Derl1"
                     /gene_synonym="1110021N07Rik; Derlin-1"
                     /coded_by="NM_024207.4:124..879"
                     /db_xref="CCDS:CCDS27484.1"
                     /db_xref="GeneID:67819"
                     /db_xref="MGI:MGI:1915069"
ORIGIN      
        1 msdigdwfrs ipaitrywfa atvavpligk lgiispayff lwpeaflyrf qiwrpftatf
       61 yfpvgpgtgf lylvnlyfly qystrleaga fdgrpadylf mllfnwiciv itglamdmql
      121 lmiplimsvl yvwaqlnrdl ivsfwfgtrf kacylpwvil gfnyiiggsv inelignlvg
      181 hlyfflmfry pmdlggrnfl stpqflyrwl psrrggvsgf gvppasmrra adqnggggrh
      241 nwgqgfrlgd q
//
LOCUS       NP_001348431             146 aa            linear   ROD 09-OCT-2023
DEFINITION  allograft inflammatory factor 1 isoform b [Mus musculus].
ACCESSION   NP_001348431
VERSION     NP_001348431.1
DBSOURCE    REFSEQ: accession NM_001361502.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 146)
  AUTHORS   Altounian M, Bellon A and Mann F.
  TITLE     Neuronal miR-17-5p contributes to interhemispheric cortical
            connectivity defects induced by prenatal alcohol exposure
  JOURNAL   Cell Rep 42 (9), 113020 (2023)
   PUBMED   37610874
REFERENCE   2  (residues 1 to 146)
  AUTHORS   Rodriguez-Lopez A, Torres-Paniagua AM, Acero G, Diaz G and
            Gevorkian G.
  TITLE     Increased TSPO expression, pyroglutamate-modified amyloid beta
            (AbetaN3(pE)) accumulation and transient clustering of microglia in
            the thalamus of Tg-SwDI mice
  JOURNAL   J Neuroimmunol 382, 578150 (2023)
   PUBMED   37467699
  REMARK    GeneRIF: Increased TSPO expression, pyroglutamate-modified amyloid
            beta (AbetaN3(pE)) accumulation and transient clustering of
            microglia in the thalamus of Tg-SwDI mice.
REFERENCE   3  (residues 1 to 146)
  AUTHORS   Cao B, Xia Y, Cai Z, Wang Z, Tang C and Song Y.
  TITLE     Construction of a Brain-specific SLC23A2 Gene Knockout Mice Model
  JOURNAL   Neuroscience 524, 137-148 (2023)
   PUBMED   37330196
REFERENCE   4  (residues 1 to 146)
  AUTHORS   Meng H, Zhao Y, Li Y, Fan H, Yi X, Meng X, Wang P, Fu F, Wu S and
            Wang Y.
  TITLE     Evidence for developmental vascular-associated necroptosis and its
            contribution to venous-lymphatic endothelial differentiation
  JOURNAL   Front Cell Dev Biol 11, 1229788 (2023)
   PUBMED   37576598
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 146)
  AUTHORS   Waldhauser V, Baroti T, Frob F and Wegner M.
  TITLE     PBAF Subunit Pbrm1 Selectively Influences the Transition from
            Progenitors to Pre-Myelinating Cells during Oligodendrocyte
            Development
  JOURNAL   Cells 12 (12), 1556 (2023)
   PUBMED   37371026
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 146)
  AUTHORS   Sasaki Y, Ohsawa K, Kanazawa H, Kohsaka S and Imai Y.
  TITLE     Iba1 is an actin-cross-linking protein in macrophages/microglia
  JOURNAL   Biochem Biophys Res Commun 286 (2), 292-297 (2001)
   PUBMED   11500035
REFERENCE   7  (residues 1 to 146)
  AUTHORS   Ohsawa K, Imai Y, Kanazawa H, Sasaki Y and Kohsaka S.
  TITLE     Involvement of Iba1 in membrane ruffling and phagocytosis of
            macrophages/microglia
  JOURNAL   J Cell Sci 113 (Pt 17), 3073-3084 (2000)
   PUBMED   10934045
REFERENCE   8  (residues 1 to 146)
  AUTHORS   Allcock RJ, Martin AM and Price P.
  TITLE     The mouse as a model for the effects of MHC genes on human disease
  JOURNAL   Immunol Today 21 (7), 328-332 (2000)
   PUBMED   10871872
  REMARK    Review article
REFERENCE   9  (residues 1 to 146)
  AUTHORS   Handel-Fernandez ME, Kurimoto I, Streilein JW and Vincek V.
  TITLE     Genetic mapping and physical cloning of UVB susceptibility region
            in mice
  JOURNAL   J Invest Dermatol 113 (2), 224-229 (1999)
   PUBMED   10469308
REFERENCE   10 (residues 1 to 146)
  AUTHORS   Lund T, Shaikh S, Kendall E, Campbell RD, Hattori M, Makino S and
            Cooke A.
  TITLE     RFLP analysis of the MHC class III region defines unique haplotypes
            for the non-obese diabetic, cataract Shionogi and the non-obese
            non-diabetic mouse strains
  JOURNAL   Diabetologia 36 (8), 727-733 (1993)
   PUBMED   8104833
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CR974444.18.
            
            Transcript Variant: This variant (3) lacks an alternate exon
            compared to variant 1. The resulting isoform (b) has a shorter and
            distinct N-terminus compared to isoform a.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BU962218.1, CN834368.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..146
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.59 cM"
     Protein         1..146
                     /product="allograft inflammatory factor 1 isoform b"
                     /note="testis specific; ionized calcium binding adapter
                     molecule 1"
                     /calculated_mol_wt=16747
     Region          <47..112
                     /region_name="PTZ00184"
                     /note="calmodulin; Provisional"
                     /db_xref="CDD:185504"
     CDS             1..146
                     /gene="Aif1"
                     /gene_synonym="AIF-1; D17H6S50E; G1; Iba1"
                     /coded_by="NM_001361502.2:143..583"
                     /note="isoform b is encoded by transcript variant 3"
                     /db_xref="GeneID:11629"
                     /db_xref="MGI:MGI:1343098"
ORIGIN      
        1 mkpeeisrgk afgllkaqqe erleginkqf lddpkysnde dlpskleafk vkymefdlng
       61 ngdidimslk rmleklgvpk thlelkrlir evssgseetf sysdflrmml gkrsailrmi
      121 lmyeeknkeh krptgppakk aiselp
//
LOCUS       NP_001394513             422 aa            linear   ROD 09-OCT-2023
DEFINITION  mitogen-activated protein kinase 10 isoform 2 [Mus musculus].
ACCESSION   NP_001394513
VERSION     NP_001394513.1
DBSOURCE    REFSEQ: accession NM_001407584.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 422)
  AUTHORS   Priego M, Noriega L, Kalinin S, Hoffman LM, Feinstein DL and
            Morfini G.
  TITLE     Genetic deletion of c-Jun amino-terminal kinase 3 (JNK3) modestly
            increases disease severity in a mouse model of multiple sclerosis
  JOURNAL   J Neuroimmunol 382, 578152 (2023)
   PUBMED   37454525
  REMARK    GeneRIF: Genetic deletion of c-Jun amino-terminal kinase 3 (JNK3)
            modestly increases disease severity in a mouse model of multiple
            sclerosis.
REFERENCE   2  (residues 1 to 422)
  AUTHORS   Liu F, Deng Y, Zhao Y, Li Z, Gao J, Zhang Y, Yang X, Liu Y and Xia
            Y.
  TITLE     Time series RNA-seq analysis identifies MAPK10 as a critical gene
            in diabetes mellitus-induced atrial fibrillation in mice
  JOURNAL   J Mol Cell Cardiol 168, 70-82 (2022)
   PUBMED   35489387
  REMARK    GeneRIF: Time series RNA-seq analysis identifies MAPK10 as a
            critical gene in diabetes mellitus-induced atrial fibrillation in
            mice.
REFERENCE   3  (residues 1 to 422)
  AUTHORS   Cunningham JG, Scripter JD, Nti SA and Tucker ES.
  TITLE     Early construction of the thalamocortical axon pathway requires
            c-Jun N-terminal kinase signaling within the ventral forebrain
  JOURNAL   Dev Dyn 251 (3), 459-480 (2022)
   PUBMED   34494344
REFERENCE   4  (residues 1 to 422)
  AUTHORS   Goodwani S, Fernandez C, Acton PJ, Buggia-Prevot V, McReynolds ML,
            Ma J, Hu CH, Hamby ME, Jiang Y, Le K, Soth MJ, Jones P and Ray WJ.
  TITLE     Dual Leucine Zipper Kinase Is Constitutively Active in the Adult
            Mouse Brain and Has Both Stress-Induced and Homeostatic Functions
  JOURNAL   Int J Mol Sci 21 (14), 4849 (2020)
   PUBMED   32659913
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 422)
  AUTHORS   Loughran G, Chou MY, Ivanov IP, Jungreis I, Kellis M, Kiran AM,
            Baranov PV and Atkins JF.
  TITLE     Evidence of efficient stop codon readthrough in four mammalian
            genes
  JOURNAL   Nucleic Acids Res 42 (14), 8928-8938 (2014)
   PUBMED   25013167
REFERENCE   6  (residues 1 to 422)
  AUTHORS   Beier H and Grimm M.
  TITLE     Misreading of termination codons in eukaryotes by natural nonsense
            suppressor tRNAs
  JOURNAL   Nucleic Acids Res 29 (23), 4767-4782 (2001)
   PUBMED   11726686
  REMARK    Review article
REFERENCE   7  (residues 1 to 422)
  AUTHORS   Yang DD, Kuan CY, Whitmarsh AJ, Rincon M, Zheng TS, Davis RJ, Rakic
            P and Flavell RA.
  TITLE     Absence of excitotoxicity-induced apoptosis in the hippocampus of
            mice lacking the Jnk3 gene
  JOURNAL   Nature 389 (6653), 865-870 (1997)
   PUBMED   9349820
REFERENCE   8  (residues 1 to 422)
  AUTHORS   Casanova E, Garate C, Ovalle S, Calvo P and Chinchetru MA.
  TITLE     Identification of four splice variants of the mouse
            stress-activated protein kinase JNK/SAPK alpha-isoform
  JOURNAL   Neuroreport 7 (7), 1320-1324 (1996)
   PUBMED   8817558
REFERENCE   9  (residues 1 to 422)
  AUTHORS   Martin JH, Mohit AA and Miller CA.
  TITLE     Developmental expression in the mouse nervous system of the p493F12
            SAP kinase
  JOURNAL   Brain Res Mol Brain Res 35 (1-2), 47-57 (1996)
   PUBMED   8717339
REFERENCE   10 (residues 1 to 422)
  AUTHORS   Suzuki J, Yoshida S, Chen ZL, Momota Y, Kato K, Hirata A and
            Shiosaka S.
  TITLE     Ontogeny of neuropsin mRNA expression in the mouse brain
  JOURNAL   Neurosci Res 23 (4), 345-351 (1995)
   PUBMED   8602273
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC160244.11, AC123664.15,
            AC137121.9 and AC125252.7.
            
            Summary: The protein encoded by this gene is a member of the MAP
            kinase family. MAP kinases act as integration points for multiple
            biochemical signals, and thus are involved in a wide variety of
            cellular processes, such as proliferation, differentiation,
            transcription regulation and development. This kinase is
            specifically expressed in a subset of neurons in the nervous system
            and is activated by threonine and tyrosine phosphorylation.
            Targeted deletion of this gene in mice suggests that it may have a
            role in stress-induced neuronal apoptosis. Alternatively spliced
            transcript variants encoding different isoforms have been found for
            this gene. A recent study provided evidence for translational
            readthrough in this gene, and expression of an additional
            C-terminally extended isoform via the use of an alternative
            in-frame translation termination codon. [provided by RefSeq, Dec
            2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10662772.1027127.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN01164131,
                                           SAMN01164138 [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..422
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 49.61 cM"
     Protein         1..422
                     /product="mitogen-activated protein kinase 10 isoform 2"
                     /EC_number="2.7.11.24"
                     /note="JNK3 beta1 protein kinase; JNK3 beta2 protein
                     kinase; MAP kinase 10; MAP kinase p49 3F12; c-Jun
                     N-terminal kinase 3; stress-activated protein kinase JNK3;
                     SAPK/Erk/kinase 2"
                     /calculated_mol_wt=48356
     Region          63..398
                     /region_name="STKc_JNK"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     c-Jun N-terminal Kinase; cd07850"
                     /db_xref="CDD:270840"
     Site            order(70..76,78,91,93,110,124,146..152,154..155,189,191,
                     193..194,196,206..207,210,221,223..226,228,265)
                     /site_type="active"
                     /db_xref="CDD:270840"
     Site            order(70..76,78,91,93,124,146..152,196,206)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270840"
     Site            order(110,154,189,191,210,221,223..226,228,265)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270840"
     Site            order(150,156,165,168,197..201,361..362,364,367)
                     /site_type="other"
                     /note="KIM docking site [polypeptide binding]"
                     /db_xref="CDD:270840"
     Site            order(206..216,220..228)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270840"
     Region          221..223
                     /region_name="TXY"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61831.2)"
     Site            221
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by MAP2K7.
                     /evidence=ECO:0000250|UniProtKB:P53779; propagated from
                     UniProtKB/Swiss-Prot (Q61831.2)"
     Site            223
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by MAP2K4.
                     /evidence=ECO:0000250|UniProtKB:P53779; propagated from
                     UniProtKB/Swiss-Prot (Q61831.2)"
     CDS             1..422
                     /gene="Mapk10"
                     /gene_synonym="C230008H04Rik; JNK3; JNK3B1; JNK3B2;
                     p493F12; p54bSAPK; SAPK(beta); Serk2"
                     /coded_by="NM_001407584.1:521..1789"
                     /note="isoform 2 is encoded by transcript variant 16"
                     /db_xref="GeneID:26414"
                     /db_xref="MGI:MGI:1346863"
ORIGIN      
        1 mslhflyycs eptldvkiaf cqgfdkhvdv ssiakhynms kskvdnqfys vevgdstftv
       61 lkryqnlkpi gsgaqgivca aydavldrnv aikklsrpfq nqthakrayr elvlmkcvnh
      121 kniisllnvf tpqktleefq dvylvmelmd anlcqviqme ldhermsyll yqmlcgikhl
      181 hsagiihrdl kpsnivvksd ctlkildfgl artagtsfmm tpyvvtryyr apevilgmgy
      241 kenvdiwsvg cimgemvrhk ilfpgrdyid qwnkvieqlg tpcpefmkkl qptvrnyven
      301 rpkyagltfp klfpdslfpa dsehnklkas qardllskml vidpakrisv ddalqhpyin
      361 vwydpaevea pppqiydkql derehtieew keliykevmn seektkngvv kgqpspsaqv
      421 qq
//
LOCUS       NP_001349220             523 aa            linear   ROD 09-OCT-2023
DEFINITION  CUGBP Elav-like family member 4 isoform 16 [Mus musculus].
ACCESSION   NP_001349220
VERSION     NP_001349220.1
DBSOURCE    REFSEQ: accession NM_001362291.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 523)
  AUTHORS   Salamon I, Park Y, Miskic T, Kopic J, Matteson P, Page NF, Roque A,
            McAuliffe GW, Favate J, Garcia-Forn M, Shah P, Judas M, Millonig
            JH, Kostovic I, De Rubeis S, Hart RP, Krsnik Z and Rasin MR.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    GeneRIF: Celf4 controls mRNA translation underlying synaptic
            development in the prenatal mammalian neocortex.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 523)
  AUTHORS   Shen Y, Zhang C, Xiao K, Liu D and Xie G.
  TITLE     CELF4 regulates spine formation and depression-like behaviors of
            mice
  JOURNAL   Biochem Biophys Res Commun 605, 39-44 (2022)
   PUBMED   35306363
  REMARK    GeneRIF: CELF4 regulates spine formation and depression-like
            behaviors of mice.
REFERENCE   3  (residues 1 to 523)
  AUTHORS   Moreau MX, Saillour Y, Cwetsch AW, Pierani A and Causeret F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   4  (residues 1 to 523)
  AUTHORS   Li C, Li X, Bi Z, Sugino K, Wang G, Zhu T and Liu Z.
  TITLE     Comprehensive transcriptome analysis of cochlear spiral ganglion
            neurons at multiple ages
  JOURNAL   Elife 9, e50491 (2020)
   PUBMED   31913118
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 523)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 523)
  AUTHORS   Ladd AN, Taffet G, Hartley C, Kearney DL and Cooper TA.
  TITLE     Cardiac tissue-specific repression of CELF activity disrupts
            alternative splicing and causes cardiomyopathy
  JOURNAL   Mol Cell Biol 25 (14), 6267-6278 (2005)
   PUBMED   15988035
  REMARK    GeneRIF: CELF protein activity is required for normal alternative
            splicing in the heart in vivo and normal CELF-mediated alternative
            splicing regulation is in turn required for normal cardiac
            function.
REFERENCE   7  (residues 1 to 523)
  AUTHORS   Meins M, Schlickum S, Wilhelm C, Missbach J, Yadav S, Glaser B,
            Grzmil M, Burfeind P and Laccone F.
  TITLE     Identification and characterization of murine Brunol4, a new member
            of the elav/bruno family
  JOURNAL   Cytogenet Genome Res 97 (3-4), 254-260 (2002)
   PUBMED   12438720
  REMARK    GeneRIF: cloning and characterization
REFERENCE   8  (residues 1 to 523)
  AUTHORS   Ladd AN, Charlet N and Cooper TA.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   9  (residues 1 to 523)
  AUTHORS   Good PJ, Chen Q, Warner SJ and Herring DC.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
REFERENCE   10 (residues 1 to 523)
  AUTHORS   Yulug IG, Egan SE, See CG and Fisher EM.
  TITLE     Mapping GRB2, a signal transduction gene in the human and the mouse
  JOURNAL   Genomics 22 (2), 313-318 (1994)
   PUBMED   7806216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121094.8 and AC144938.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660819.199204.1,
                                           SRR1660825.193961.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..523
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 13.92 cM"
     Protein         1..523
                     /product="CUGBP Elav-like family member 4 isoform 16"
                     /note="CUG-BP- and ETR-3-like factor 4; bruno-like protein
                     4; RNA-binding protein BRUNOL-4; bruno-like 4, RNA binding
                     protein"
                     /calculated_mol_wt=55680
     Region          49..135
                     /region_name="RRM1_CELF3_4_5_6"
                     /note="RNA recognition motif 1 (RRM1) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12632"
                     /db_xref="CDD:410041"
     Site            order(55,57,59..60,63,82,84,86,95..97,99,129,131)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410041"
     Region          140..220
                     /region_name="RRM2_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12635"
                     /db_xref="CDD:410043"
     Site            order(142,144,146..147,150,169,171,173,181..183,185,215,
                     217)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410043"
     Region          404..>432
                     /region_name="RRM_SF"
                     /note="RNA recognition motif (RRM) superfamily; cl17169"
                     /db_xref="CDD:450164"
     CDS             1..523
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /coded_by="NM_001362291.1:531..2102"
                     /note="isoform 16 is encoded by transcript variant 22"
                     /db_xref="GeneID:108013"
                     /db_xref="MGI:MGI:1932407"
ORIGIN      
        1 myikmatlan gqadnaslst nglgsspgsa ghmnglshsp gnpstipmkd hdaiklfigq
       61 iprnldekdl kplfeefgki yeltvlkdrf tgmhkgcafl tyceresalk aqsalheqkt
      121 lpgmnrpiqv kpadsesrgd rklfvgmlnk qqseddvrrl feafgnieec tilrgpdgns
      181 kgcafvkyss haeaqaaina lhgsqtmpga ssslvvkfad tdkertmrrm qqmagqmgmf
      241 npmaipfgay gayaqamqqq aalmasvaqg gylnpmaafa aaqmqqmaal nmnglaaapm
      301 tptsggstpp gitapavpsi pspigvngft glppqangqp aaeavfangi hpypaqspta
      361 adplqqayag vqqyagpayp aaygqisqaf pqpppmipqq qregpegcnl liyhlpqefg
      421 daelmqmflp fgrhpvpsrc qapscqggqc aisssarrlr elrqpgqrtd rhpgherlpd
      481 rheeaqgaae aaqrrqspvl saggsvprgr pglaqgrmln glh
//
LOCUS       NP_112455               1032 aa            linear   ROD 09-OCT-2023
DEFINITION  toll-like receptor 9 precursor [Mus musculus].
ACCESSION   NP_112455
VERSION     NP_112455.2
DBSOURCE    REFSEQ: accession NM_031178.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1032)
  AUTHORS   Cakan E, Ah Kioon MD, Garcia-Carmona Y, Glauzy S, Oliver D,
            Yamakawa N, Vega Loza A, Du Y, Schickel JN, Boeckers JM, Yang C,
            Baldo A, Ivashkiv LB, Young RM, Staudt LM, Moody KL, Nundel K,
            Marshak-Rothstein A, van der Made CI, Hoischen A, Hayward A,
            Rossato M, Radstake TRDJ, Cunningham-Rundles C, Ryu C, Herzog EL,
            Barrat FJ and Meffre E.
  TITLE     TLR9 ligand sequestration by chemokine CXCL4 negatively affects
            central B cell tolerance
  JOURNAL   J Exp Med 220 (12) (2023)
   PUBMED   37773045
  REMARK    GeneRIF: TLR9 ligand sequestration by chemokine CXCL4 negatively
            affects central B cell tolerance.
REFERENCE   2  (residues 1 to 1032)
  AUTHORS   Wang YN, Gan T, Qu S, Xu LL, Hu Y, Liu LJ, Shi SF, Lv JC, Tsoi LC,
            Patrick MT, He K, Berthier CC, Xu HJ, Zhou XJ and Zhang H.
  TITLE     MTMR3 risk alleles enhance Toll Like Receptor 9-induced IgA
            immunity in IgA nephropathy
  JOURNAL   Kidney Int 104 (3), 562-576 (2023)
   PUBMED   37414396
  REMARK    GeneRIF: MTMR3 risk alleles enhance Toll Like Receptor 9-induced
            IgA immunity in IgA nephropathy.
REFERENCE   3  (residues 1 to 1032)
  AUTHORS   Gavin AL, Blane TR, Thinnes TC, Gerlt E, Marshak-Rothstein A, Huang
            D and Nemazee D.
  TITLE     Disease in the Pld4thss/thss Model of Murine Lupus Requires TLR9
  JOURNAL   Immunohorizons 7 (8), 577-586 (2023)
   PUBMED   37555846
  REMARK    GeneRIF: Disease in the Pld4thss/thss Model of Murine Lupus
            Requires TLR9.
REFERENCE   4  (residues 1 to 1032)
  AUTHORS   Velasco WV, Khosravi N, Castro-Pando S, Torres-Garza N, Grimaldo
            MT, Krishna A, Clowers MJ, Umer M, Tariq Amir S, Del Bosque D,
            Daliri S, De La Garza MM, Ramos-Castaneda M, Evans SE and Moghaddam
            SJ.
  TITLE     Toll-like receptors 2, 4, and 9 modulate promoting effect of
            COPD-like airway inflammation on K-ras-driven lung cancer through
            activation of the MyD88/NF-kB pathway in the airway epithelium
  JOURNAL   Front Immunol 14, 1118721 (2023)
   PUBMED   37283745
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1032)
  AUTHORS   Zhang S and Cao X.
  TITLE     TLR9 triggers MyD88-independent anti-inflammatory signaling in
            lupus
  JOURNAL   Trends Immunol 44 (3), 153-155 (2023)
   PUBMED   36740514
  REMARK    GeneRIF: TLR9 triggers MyD88-independent anti-inflammatory
            signaling in lupus.
REFERENCE   6  (residues 1 to 1032)
  AUTHORS   Suzuki N, Suzuki S, Duncan GS, Millar DG, Wada T, Mirtsos C, Takada
            H, Wakeham A, Itie A, Li S, Penninger JM, Wesche H, Ohashi PS, Mak
            TW and Yeh WC.
  TITLE     Severe impairment of interleukin-1 and Toll-like receptor
            signalling in mice lacking IRAK-4
  JOURNAL   Nature 416 (6882), 750-756 (2002)
   PUBMED   11923871
  REMARK    GeneRIF: Severe impairment of interleukin-1 and Toll-like receptor
            signalling in mice lacking IRAK-4.
REFERENCE   7  (residues 1 to 1032)
  AUTHORS   Chuang TH, Lee J, Kline L, Mathison JC and Ulevitch RJ.
  TITLE     Toll-like receptor 9 mediates CpG-DNA signaling
  JOURNAL   J Leukoc Biol 71 (3), 538-544 (2002)
   PUBMED   11867692
  REMARK    GeneRIF: TLR9 acts at the cell surface and engages an intracellular
            signaling pathway that includes MyD88, IRAK, and TRAF6
REFERENCE   8  (residues 1 to 1032)
  AUTHORS   Hemmi H, Kaisho T, Takeuchi O, Sato S, Sanjo H, Hoshino K, Horiuchi
            T, Tomizawa H, Takeda K and Akira S.
  TITLE     Small anti-viral compounds activate immune cells via the TLR7
            MyD88-dependent signaling pathway
  JOURNAL   Nat Immunol 3 (2), 196-200 (2002)
   PUBMED   11812998
REFERENCE   9  (residues 1 to 1032)
  AUTHORS   Bauer S, Kirschning CJ, Hacker H, Redecke V, Hausmann S, Akira S,
            Wagner H and Lipford GB.
  TITLE     Human TLR9 confers responsiveness to bacterial DNA via
            species-specific CpG motif recognition
  JOURNAL   Proc Natl Acad Sci U S A 98 (16), 9237-9242 (2001)
   PUBMED   11470918
REFERENCE   10 (residues 1 to 1032)
  AUTHORS   Hemmi H, Takeuchi O, Kawai T, Kaisho T, Sato S, Sanjo H, Matsumoto
            M, Hoshino K, Wagner H, Takeda K and Akira S.
  TITLE     A Toll-like receptor recognizes bacterial DNA
  JOURNAL   Nature 408 (6813), 740-745 (2000)
   PUBMED   11130078
  REMARK    Erratum:[Nature 2001 Feb 1;409(6820):646]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC164430.3.
            
            On Sep 7, 2007 this sequence version replaced NP_112455.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB045181.1, AF314224.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1032
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 57.46 cM"
     Protein         1..1032
                     /product="toll-like receptor 9 precursor"
                     /calculated_mol_wt=113659
     sig_peptide     1..25
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=2772
     Region          <24..>254
                     /region_name="PRK15370"
                     /note="type III secretion system effector E3 ubiquitin
                     transferase SlrP"
                     /db_xref="CDD:185268"
     Region          43..64
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          62..85
                     /region_name="LRR 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Site            64
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          65..88
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          87..110
                     /region_name="LRR 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          122..147
                     /region_name="LRR 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          125..168
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            129
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Site            147
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          150..166
                     /region_name="LRR 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          167..190
                     /region_name="LRR 5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          169..200
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          198..221
                     /region_name="LRR 6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          199..>651
                     /region_name="PLN00113"
                     /note="leucine-rich repeat receptor-like protein kinase;
                     Provisional"
                     /db_xref="CDD:215061"
     Site            200
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          201..221
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            210
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255, ECO:0000269|PubMed:25686612,
                     ECO:0007744|PDB:3WPF; propagated from UniProtKB/Swiss-Prot
                     (Q9EQU3.3)"
     Region          222..245
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          223..242
                     /region_name="LRR 7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Site            242
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          243..268
                     /region_name="LRR 8"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          246..285
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          283..306
                     /region_name="LRR 9"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          286..309
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            300
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          308..332
                     /region_name="LRR 10"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Site            309
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          310..335
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            332
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255, ECO:0000269|PubMed:25686612,
                     ECO:0007744|PDB:3WPF, ECO:0007744|PDB:3WPH; propagated
                     from UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          333..356
                     /region_name="LRR 11"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          336..365
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            340
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          363..386
                     /region_name="LRR 12"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          390..413
                     /region_name="LRR 13"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          393..422
                     /region_name="LRR_12"
                     /note="Leucine-rich repeat; pfam18837"
                     /db_xref="CDD:408607"
     Region          393..411
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          415..440
                     /region_name="LRR 14"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          430..462
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          471..495
                     /region_name="LRR 15"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          477..498
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            495
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          497..520
                     /region_name="LRR 16"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          499..523
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            514
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          521..544
                     /region_name="LRR 17"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          524..547
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          546..573
                     /region_name="LRR 18"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          548..577
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            568
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          575..599
                     /region_name="LRR 19"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          578..600
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          601..630
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          601..623
                     /region_name="LRR 20"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          <623..690
                     /region_name="LRR_8"
                     /note="Leucine rich repeat; pfam13855"
                     /db_xref="CDD:404697"
     Region          628..651
                     /region_name="LRR 21"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          631..679
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          653..676
                     /region_name="LRR 22"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Site            670
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          677..700
                     /region_name="LRR 23"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          680..703
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            695
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Site            700
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          702..724
                     /region_name="LRR 24"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          704..752
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          725..748
                     /region_name="LRR 25"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Site            732
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255, ECO:0000269|PubMed:25686612,
                     ECO:0007744|PDB:3WPF, ECO:0007744|PDB:3WPG,
                     ECO:0007744|PDB:3WPH, ECO:0007744|PDB:3WPI; propagated
                     from UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          750..773
                     /region_name="LRR 26"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Site            752
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          753..774
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            819..839
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQU3.3)"
     Region          870..>974
                     /region_name="TIR_2"
                     /note="TIR domain; cl23749"
                     /db_xref="CDD:451524"
     CDS             1..1032
                     /gene="Tlr9"
                     /coded_by="NM_031178.2:107..3205"
                     /db_xref="CCDS:CCDS40755.1"
                     /db_xref="GeneID:81897"
                     /db_xref="MGI:MGI:1932389"
ORIGIN      
        1 mvlrrrtlhp lsllvqaavl aetlalgtlp aflpcelkph glvdcnwlfl ksvprfsaaa
       61 scsnitrlsl isnrihhlhn sdfvhlsnlr qlnlkwncpp tglsplhfsc hmtieprtfl
      121 amrtleelnl syngittvpr lpsslvnlsl shtnilvlda nslaglyslr vlfmdgncyy
      181 knpctgavkv tpgallglsn lthlslkynn ltkvprqlpp sleyllvsyn livklgpedl
      241 anltslrvld vggncrrcdh apnpciecgq kslhlhpetf hhlshleglv lkdsslhtln
      301 sswfqglvnl svldlsenfl yesithtnaf qnltrlrkln lsfnyrkkvs farlhlassf
      361 knlvslqeln mngiffrlln kytlrwladl pklhtlhlqm nfinqaqlsi fgtfralrfv
      421 dlsdnrisgp stlseatpee addaeqeell sadphpapls tpasknfmdr cknfkftmdl
      481 srnnlvtikp emfvnlsrlq clslshnsia qavngsqflp ltnlqvldls hnkldlyhwk
      541 sfselpqlqa ldlsynsqpf smkgighnfs fvthlsmlqs lslahndiht rvsshlnsns
      601 vrfldfsgng mgrmwdeggl ylhffqglsg llkldlsqnn lhilrpqnld nlpkslklls
      661 lrdnylsffn wtslsflpnl evldlagnql kaltngtlpn gtllqkldvs snsivsvvpa
      721 ffalavelke vnlshnilkt vdrswfgpiv mnltvldvrs nplhcacgaa fvdlllevqt
      781 kvpglangvk cgspgqlqgr sifaqdlrlc ldevlswdcf glsllavavg mvvpilhhlc
      841 gwdvwycfhl clawlpllar srrsaqtlpy dafvvfdkaq savadwvyne lrvrleerrg
      901 rralrlcled rdwlpgqtlf enlwasiygs rktlfvlaht drvsgllrts fllaqqrlle
      961 drkdvvvlvi lrpdahrsry vrlrqrlcrq svlfwpqqpn gqggfwaqls taltrdnrhf
     1021 ynqnfcrgpt ae
//
LOCUS       NP_001259007             249 aa            linear   ROD 09-OCT-2023
DEFINITION  triggering receptor expressed on myeloid cells 2 isoform 2
            precursor [Mus musculus].
ACCESSION   NP_001259007
VERSION     NP_001259007.1
DBSOURCE    REFSEQ: accession NM_001272078.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 249)
  AUTHORS   Chen X, Zhao Y, Huang Y, Zhu K, Zeng F, Zhao J, Zhang H, Zhu X,
            Kettenmann H and Xiang X.
  TITLE     TREM2 promotes glioma progression and angiogenesis mediated by
            microglia/brain macrophages
  JOURNAL   Glia 71 (11), 2679-2695 (2023)
   PUBMED   37641212
  REMARK    GeneRIF: TREM2 promotes glioma progression and angiogenesis
            mediated by microglia/brain macrophages.
REFERENCE   2  (residues 1 to 249)
  AUTHORS   Das M, Mao W, Voskobiynyk Y, Necula D, Lew I, Petersen C, Zahn A,
            Yu GQ, Yu X, Smith N, Sayed FA, Gan L, Paz JT and Mucke L.
  TITLE     Alzheimer risk-increasing TREM2 variant causes aberrant cortical
            synapse density and promotes network hyperexcitability in mouse
            models
  JOURNAL   Neurobiol Dis 186, 106263 (2023)
   PUBMED   37591465
  REMARK    GeneRIF: Alzheimer risk-increasing TREM2 variant causes aberrant
            cortical synapse density and promotes network hyperexcitability in
            mouse models.
REFERENCE   3  (residues 1 to 249)
  AUTHORS   Zhong L, Sheng X, Wang W, Li Y, Zhuo R, Wang K, Zhang L, Hu DD,
            Hong Y, Chen L, Rao H, Li T, Chen M, Lin Z, Zhang YW, Wang X, Yan
            XX, Chen X, Bu G and Chen XF.
  TITLE     TREM2 receptor protects against complement-mediated synaptic loss
            by binding to complement C1q during neurodegeneration
  JOURNAL   Immunity 56 (8), 1794-1808 (2023)
   PUBMED   37442133
  REMARK    GeneRIF: TREM2 receptor protects against complement-mediated
            synaptic loss by binding to complement C1q during
            neurodegeneration.
REFERENCE   4  (residues 1 to 249)
  AUTHORS   Yoo Y, Neumayer G, Shibuya Y, Mader MM and Wernig M.
  TITLE     A cell therapy approach to restore microglial Trem2 function in a
            mouse model of Alzheimer's disease
  JOURNAL   Cell Stem Cell 30 (8), 1043-1053 (2023)
   PUBMED   37541210
  REMARK    Erratum:[Cell Stem Cell. 2023 Oct 5;30(10):1392. PMID: 37802040]
REFERENCE   5  (residues 1 to 249)
  AUTHORS   Correale C, Genua M, Vetrano S, Mazzini E, Martinoli C, Spinelli A,
            Arena V, Peyrin-Biroulet L, Caprioli F, Passini N, Panina-Bordignon
            P, Repici A, Malesci A, Rutella S, Rescigno M and Danese S.
  TITLE     Bacterial sensor triggering receptor expressed on myeloid cells-2
            regulates the mucosal inflammatory response
  JOURNAL   Gastroenterology 144 (2), 346-356 (2013)
   PUBMED   23108068
REFERENCE   6  (residues 1 to 249)
  AUTHORS   Daws MR, Sullam PM, Niemi EC, Chen TT, Tchao NK and Seaman WE.
  TITLE     Pattern recognition by TREM-2: binding of anionic ligands
  JOURNAL   J Immunol 171 (2), 594-599 (2003)
   PUBMED   12847223
  REMARK    GeneRIF: TREM-2a and TREM-2b binding to both Gram-positive and
            Gram-negative bacteria is disrupted by anionic bacterial products
            or other anionic carbohydrates and suggests that TREM-2 recognizes
            pathogens via charged carbohydrates expressed on pathogen surface.
REFERENCE   7  (residues 1 to 249)
  AUTHORS   Schmid CD, Sautkulis LN, Danielson PE, Cooper J, Hasel KW, Hilbush
            BS, Sutcliffe JG and Carson MJ.
  TITLE     Heterogeneous expression of the triggering receptor expressed on
            myeloid cells-2 on adult murine microglia
  JOURNAL   J Neurochem 83 (6), 1309-1320 (2002)
   PUBMED   12472885
REFERENCE   8  (residues 1 to 249)
  AUTHORS   Chung DH, Seaman WE and Daws MR.
  TITLE     Characterization of TREM-3, an activating receptor on mouse
            macrophages: definition of a family of single Ig domain receptors
            on mouse chromosome 17
  JOURNAL   Eur J Immunol 32 (1), 59-66 (2002)
   PUBMED   11754004
REFERENCE   9  (residues 1 to 249)
  AUTHORS   Daws MR, Lanier LL, Seaman WE and Ryan JC.
  TITLE     Cloning and characterization of a novel mouse myeloid
            DAP12-associated receptor family
  JOURNAL   Eur J Immunol 31 (3), 783-791 (2001)
   PUBMED   11241283
REFERENCE   10 (residues 1 to 249)
  AUTHORS   Bouchon A, Dietrich J and Colonna M.
  TITLE     Cutting edge: inflammatory responses can be triggered by TREM-1, a
            novel receptor expressed on neutrophils and monocytes
  JOURNAL   J Immunol 164 (10), 4991-4995 (2000)
   PUBMED   10799849
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC166164.2, AY187009.1,
            AK039477.1 and BY541740.1.
            
            Summary: The protein encoded by this gene is part of the
            immunoglobulin and lectin-like superfamily and functions as part of
            the innate immune system. This gene forms part of a cluster of
            genes on mouse chromosome 17 thought to be involved in innate
            immunity. This protein associates with the adaptor protein Dap-12
            and recruits several factors, such as kinases and phospholipase
            C-gamma, to form a receptor signaling complex that activates
            myeloid cells, including dendritic cells and microglia. In humans
            homozygous loss-of-function mutations in this gene cause
            Nasu-Hakola disease and mutations in this gene may be risk factors
            to the development of Alzheimer's disease. In mouse mutations of
            this gene serve as a pathophysiological model for polycystic
            lipomembranous osteodysplasia with sclerosing leukoencephalopathy
            (Nasu-Hakola disease) and for inflammatory bowel disease.
            Alternative splicing results in multiple transcript variants that
            encode different protein isoforms. [provided by RefSeq, Jan 2013].
            
            Transcript Variant: This variant (2) uses an alternate acceptor
            splice site in the 3' coding region, which results in a frameshift,
            compared to variant 1. It encodes isoform 2, which has a longer and
            distinct C-terminus that lacks a transmembrane domain, compared to
            isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155163.1, AY187009.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..249
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 23.99 cM"
     Protein         1..249
                     /product="triggering receptor expressed on myeloid cells 2
                     isoform 2 precursor"
                     /note="triggering receptor expressed on myeloid cells 2b;
                     triggering receptor expressed on myeloid cells 2c;
                     triggering receptor expressed on myeloid cells 2a;
                     triggering receptor expressed on monocytes 2"
                     /calculated_mol_wt=25356
     sig_peptide     1..18
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=1966
     Region          21..128
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:448366"
     Region          32..36
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          47..51
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          93..97
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          107..112
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          123..126
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     CDS             1..249
                     /gene="Trem2"
                     /gene_synonym="TREM-2; Trem2a; Trem2b; Trem2c"
                     /coded_by="NM_001272078.1:156..905"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2"
                     /db_xref="CCDS:CCDS70825.1"
                     /db_xref="GeneID:83433"
                     /db_xref="MGI:MGI:1913150"
ORIGIN      
        1 mgplhqflll litalsqaln ttvlqgmagq slrvsctyda lkhwgrrkaw crqlgeegpc
       61 qrvvsthgvw llaflkkrng stviaddtla gtvtitlknl qagdaglyqc qslrgreaev
      121 lqkvlvevle dplddqdagd lwvpeesssf egaqvehsts rqvsscgspl ayhlpplske
      181 srdllpthlh ssppglrspe qvscsqhplg cgqgqaeagn tcgqraglwp rcwaptsdph
      241 wtrryvref
//
LOCUS       NP_082549                287 aa            linear   ROD 09-OCT-2023
DEFINITION  serine/threonine-protein phosphatase PGAM5, mitochondrial isoform 2
            [Mus musculus].
ACCESSION   NP_082549 XP_132261
VERSION     NP_082549.2
DBSOURCE    REFSEQ: accession NM_028273.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 287)
  AUTHORS   Cai C, Li Z, Zheng Z, Guo Z, Li Q, Deng S, Shi N, Ou Q, Zhou H, Guo
            Z, Chen Z and Zhu H.
  TITLE     Pgam5-mediated PHB2 dephosphorylation contributes to
            endotoxemia-induced myocardial dysfunction by inhibiting mitophagy
            and the mitochondrial unfolded protein response
  JOURNAL   Int J Biol Sci 19 (14), 4657-4671 (2023)
   PUBMED   37781037
  REMARK    GeneRIF: Pgam5-mediated PHB2 dephosphorylation contributes to
            endotoxemia-induced myocardial dysfunction by inhibiting mitophagy
            and the mitochondrial unfolded protein response.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 287)
  AUTHORS   Dai C, Qu B, Peng B, Liu B, Li Y, Niu C, Peng B and Li D.
  TITLE     Phosphoglycerate mutase 5 facilitates mitochondrial dysfunction and
            neuroinflammation in spinal tissues after spinal cord injury
  JOURNAL   Int Immunopharmacol 116, 109773 (2023)
   PUBMED   36773566
  REMARK    GeneRIF: Phosphoglycerate mutase 5 facilitates mitochondrial
            dysfunction and neuroinflammation in spinal tissues after spinal
            cord injury.
REFERENCE   3  (residues 1 to 287)
  AUTHORS   Li J, Sun X, Yang N, Ni J, Xie H, Guo H, Wang X, Zhou L, Liu J,
            Chen S, Wang X, Zhang Y, Yu C, Zhang W and Lu L.
  TITLE     Phosphoglycerate mutase 5 initiates inflammation in acute kidney
            injury by triggering mitochondrial DNA release by dephosphorylating
            the pro-apoptotic protein Bax
  JOURNAL   Kidney Int 103 (1), 115-133 (2023)
   PUBMED   36089186
  REMARK    GeneRIF: Phosphoglycerate mutase 5 initiates inflammation in acute
            kidney injury by triggering mitochondrial DNA release by
            dephosphorylating the pro-apoptotic protein Bax.
REFERENCE   4  (residues 1 to 287)
  AUTHORS   Denk D, Petrocelli V, Conche C, Drachsler M, Ziegler PK, Braun A,
            Kress A, Nicolas AM, Mohs K, Becker C, Neurath MF, Farin HF,
            Buchholz CJ, Andreux PA, Rinsch C and Greten FR.
  TITLE     Expansion of T memory stem cells with superior anti-tumor immunity
            by Urolithin A-induced mitophagy
  JOURNAL   Immunity 55 (11), 2059-2073 (2022)
   PUBMED   36351375
REFERENCE   5  (residues 1 to 287)
  AUTHORS   Zhu P, Wang J, Du W, Ren J, Zhang Y, Xie F and Xu G.
  TITLE     NR4A1 Promotes LPS-Induced Acute Lung Injury through Inhibition of
            Opa1-Mediated Mitochondrial Fusion and Activation of PGAM5-Related
            Necroptosis
  JOURNAL   Oxid Med Cell Longev 2022, 6638244 (2022)
   PUBMED   35222801
  REMARK    GeneRIF: NR4A1 Promotes LPS-Induced Acute Lung Injury through
            Inhibition of Opa1-Mediated Mitochondrial Fusion and Activation of
            PGAM5-Related Necroptosis.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 287)
  AUTHORS   Kang YJ, Bang BR, Han KH, Hong L, Shim EJ, Ma J, Lerner RA and
            Otsuka M.
  TITLE     Regulation of NKT cell-mediated immune responses to tumours and
            liver inflammation by mitochondrial PGAM5-Drp1 signalling
  JOURNAL   Nat Commun 6, 8371 (2015)
   PUBMED   26381214
  REMARK    GeneRIF: Results identify a crucial role for RIPK3-PGAM5-Drp1/NFAT
            signalling in NKT cell activation, and further suggest that
            RIPK3-PGAM5 signalling may mediate crosstalk between mitochondrial
            function and immune signalling.
            Publication Status: Online-Only
REFERENCE   7  (residues 1 to 287)
  AUTHORS   Lu W, Karuppagounder SS, Springer DA, Allen MD, Zheng L, Chao B,
            Zhang Y, Dawson VL, Dawson TM and Lenardo M.
  TITLE     Genetic deficiency of the mitochondrial protein PGAM5 causes a
            Parkinson's-like movement disorder
  JOURNAL   Nat Commun 5, 4930 (2014)
   PUBMED   25222142
  REMARK    GeneRIF: Loss of PGAM5 disables PINK1-mediated mitophagy in vitro
            and leads to dopaminergic neurodegeneration and mild dopamine loss
            in vivo causing a Parkinson's-like movement disorder.
            Publication Status: Online-Only
REFERENCE   8  (residues 1 to 287)
  AUTHORS   Wilkins JM, McConnell C, Tipton PA and Hannink M.
  TITLE     A conserved motif mediates both multimer formation and allosteric
            activation of phosphoglycerate mutase 5
  JOURNAL   J Biol Chem 289 (36), 25137-25148 (2014)
   PUBMED   25012655
  REMARK    GeneRIF: Data indicate that phosphoglycerate mutase 5 (PGAM5)
            contains an N-terminal WDXNWD motif required for multimerization
            and maximal phosphatase activity.
REFERENCE   9  (residues 1 to 287)
  AUTHORS   Wang Z, Jiang H, Chen S, Du F and Wang X.
  TITLE     The mitochondrial phosphatase PGAM5 functions at the convergence
            point of multiple necrotic death pathways
  JOURNAL   Cell 148 (1-2), 228-243 (2012)
   PUBMED   22265414
  REMARK    GeneRIF: Experimental data indicate that the two splice variants of
            the mitochondrial protein phosphatase PGAM5 are at the convergent
            point of multiple necrosis pathways.
REFERENCE   10 (residues 1 to 287)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY101410.1, BC138925.1, AK034588.1 and BY620990.1.
            
            On Jul 23, 2009 this sequence version replaced NP_082549.1.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 3' coding region, compared to variant 1, which
            results in a protein (isoform 2) which is 1 amino acid shorter than
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK034588.1, SRR1660817.94988.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..287
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 53.43 cM"
     Protein         1..287
                     /product="serine/threonine-protein phosphatase PGAM5,
                     mitochondrial isoform 2"
                     /EC_number="3.1.3.16"
                     /note="serine/threonine-protein phosphatase PGAM5,
                     mitochondrial"
                     /calculated_mol_wt=31735
     Site            7..29
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BX10.1)"
     Region          13..285
                     /region_name="HP"
                     /note="Histidine phosphatase domain found in a
                     functionally diverse set of proteins, mostly phosphatases;
                     contains a His residue which is phosphorylated during the
                     reaction; cl11399"
                     /db_xref="CDD:448243"
     Site            24..25
                     /site_type="cleavage"
                     /note="Cleavage, by PARL.
                     /evidence=ECO:0000250|UniProtKB:Q96HS1; propagated from
                     UniProtKB/Swiss-Prot (Q8BX10.1)"
     Region          76..81
                     /region_name="Interaction with KEAP1.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BX10.1)"
     Site            79
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96HS1; propagated from
                     UniProtKB/Swiss-Prot (Q8BX10.1)"
     Site            86
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96HS1; propagated from
                     UniProtKB/Swiss-Prot (Q8BX10.1)"
     Site            order(103..104,151,228..229)
                     /site_type="active"
                     /note="catalytic core [active]"
                     /db_xref="CDD:132718"
     Site            115
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q96HS1; propagated from
                     UniProtKB/Swiss-Prot (Q8BX10.1)"
     Site            143
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q96HS1; propagated from
                     UniProtKB/Swiss-Prot (Q8BX10.1)"
     Site            190
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q96HS1; propagated from
                     UniProtKB/Swiss-Prot (Q8BX10.1)"
     CDS             1..287
                     /gene="Pgam5"
                     /gene_synonym="2610528A17Rik"
                     /coded_by="NM_028273.3:61..924"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS19523.1"
                     /db_xref="GeneID:72542"
                     /db_xref="MGI:MGI:1919792"
ORIGIN      
        1 mafrqalqla acglaggsaa vlfsavavgk prgggdadtr ateppawtga ragrgvwdtn
       61 wdrreplsli nlkkrnvesg edeltsrldh ykakatrhif lirhsqyhvd gslekdrtlt
      121 plgreqaelt glrlaslglk fnkivhssmt ravettdiis khlpgvsrvs tdllregapi
      181 epdppvshwk peavyyedga rieaafrnyi hradarqeed syeifichan viryivcral
      241 qfppegwlrl slnngsithl virpngrval rtlgdtgfmp pdkitrs
//
LOCUS       NP_032521                135 aa            linear   ROD 09-OCT-2023
DEFINITION  galectin-1 [Mus musculus].
ACCESSION   NP_032521
VERSION     NP_032521.1
DBSOURCE    REFSEQ: accession NM_008495.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 135)
  AUTHORS   Kiss T, Mir Y, Stefancsik G, Ganbat G, Askarova A, Monostori E,
            Dulka K, Szebeni GJ, Nyul-Toth A, Csiszar A and Legradi A.
  TITLE     Galectin-1 as a marker for microglia activation in the aging brain
  JOURNAL   Brain Res 1818, 148517 (2023)
   PUBMED   37557976
  REMARK    GeneRIF: Galectin-1 as a marker for microglia activation in the
            aging brain.
REFERENCE   2  (residues 1 to 135)
  AUTHORS   Zheng Y, Zhang H, Xiao C, Deng Z, Fan T, Zheng B, Li C and He J.
  TITLE     KLF12 overcomes anti-PD-1 resistance by reducing galectin-1 in
            cancer cells
  JOURNAL   J Immunother Cancer 11 (8) (2023)
   PUBMED   37586772
  REMARK    GeneRIF: KLF12 overcomes anti-PD-1 resistance by reducing
            galectin-1 in cancer cells.
REFERENCE   3  (residues 1 to 135)
  AUTHORS   Feng C, Cross AS and Vasta GR.
  TITLE     Galectin-1 mediates interactions between polymorphonuclear
            leukocytes and vascular endothelial cells, and promotes their
            extravasation during lipopolysaccharide-induced acute lung injury
  JOURNAL   Mol Immunol 156, 127-135 (2023)
   PUBMED   36921487
  REMARK    GeneRIF: Galectin-1 mediates interactions between polymorphonuclear
            leukocytes and vascular endothelial cells, and promotes their
            extravasation during lipopolysaccharide-induced acute lung injury.
REFERENCE   4  (residues 1 to 135)
  AUTHORS   Cai S, Si N, Wang Y and Yin N.
  TITLE     Transcriptomic analysis of the upper lip and primary palate
            development in mice
  JOURNAL   Front Genet 13, 1039850 (2023)
   PUBMED   36685938
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 135)
  AUTHORS   Li J, Pan Y, Yang J, Wang J, Jiang Q, Dou H and Hou Y.
  TITLE     Tumor necrosis factor-alpha-primed mesenchymal stem cell-derived
            exosomes promote M2 macrophage polarization via Galectin-1 and
            modify intrauterine adhesion on a novel murine model
  JOURNAL   Front Immunol 13, 945234 (2022)
   PUBMED   36591221
  REMARK    GeneRIF: Tumor necrosis factor-alpha-primed mesenchymal stem
            cell-derived exosomes promote M2 macrophage polarization via
            Galectin-1 and modify intrauterine adhesion on a novel murine
            model.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 135)
  AUTHORS   Wells V and Mallucci L.
  TITLE     Molecular expression of the negative growth factor murine
            beta-galactoside binding protein (mGBP)
  JOURNAL   Biochim Biophys Acta 1121 (3), 239-244 (1992)
   PUBMED   1627600
REFERENCE   7  (residues 1 to 135)
  AUTHORS   Poirier F, Timmons PM, Chan CT, Guenet JL and Rigby PW.
  TITLE     Expression of the L14 lectin during mouse embryogenesis suggests
            multiple roles during pre- and post-implantation development
  JOURNAL   Development 115 (1), 143-155 (1992)
   PUBMED   1638977
REFERENCE   8  (residues 1 to 135)
  AUTHORS   Chiariotti L, Wells V, Bruni CB and Mallucci L.
  TITLE     Structure and expression of the negative growth factor mouse
            beta-galactoside binding protein gene
  JOURNAL   Biochim Biophys Acta 1089 (1), 54-60 (1991)
   PUBMED   2025648
REFERENCE   9  (residues 1 to 135)
  AUTHORS   Wells V and Mallucci L.
  TITLE     Identification of an autocrine negative growth factor: mouse
            beta-galactoside-binding protein is a cytostatic factor and cell
            growth regulator
  JOURNAL   Cell 64 (1), 91-97 (1991)
   PUBMED   1986871
REFERENCE   10 (residues 1 to 135)
  AUTHORS   Cooper DN and Barondes SH.
  TITLE     Evidence for export of a muscle lectin from cytosol to
            extracellular matrix and for a novel secretory mechanism
  JOURNAL   J Cell Biol 110 (5), 1681-1691 (1990)
   PUBMED   2335567
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            X66532.1 and BE956470.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X66532.1, BY704534.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..135
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 37.7 cM"
     Protein         1..135
                     /product="galectin-1"
                     /note="beta-galactoside binding protein; galaptin; 14 kDa
                     lectin; S-Lac lectin 1; lactose-binding lectin 1; lectin
                     galactoside-binding soluble 1; beta-galactoside-binding
                     lectin L-14-I"
                     /calculated_mol_wt=14735
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:P09382; propagated from
                     UniProtKB/Swiss-Prot (P16045.3)"
     Region          11..135
                     /region_name="GLECT"
                     /note="Galectin; smart00276"
                     /db_xref="CDD:214596"
     Site            order(13..15,18,21,91..93,98,100,103)
                     /site_type="other"
                     /note="putative alternate dimerization interface
                     [polypeptide binding]"
                     /db_xref="CDD:238025"
     Site            13
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P16045.3)"
     Site            19
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P16045.3)"
     Site            29
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P16045.3)"
     Site            30
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P09382; propagated from
                     UniProtKB/Swiss-Prot (P16045.3)"
     Site            order(45,47,49,60,62,69,72,74)
                     /site_type="other"
                     /note="sugar binding pocket [chemical binding]"
                     /db_xref="CDD:238025"
     Site            108
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P16045.3)"
     Site            128
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P16045.3)"
     CDS             1..135
                     /gene="Lgals1"
                     /gene_synonym="Gal-1; Galbp; galectin-1; L-14.5; L14;
                     Lect14"
                     /coded_by="NM_008495.2:72..479"
                     /db_xref="CCDS:CCDS27628.1"
                     /db_xref="GeneID:16852"
                     /db_xref="MGI:MGI:96777"
ORIGIN      
        1 macglvasnl nlkpgeclkv rgevasdaks fvlnlgkdsn nlclhfnprf nahgdantiv
       61 cntkedgtwg tehrepafpf qpgsitevci tfdqadltik lpdghefkfp nrlnmeainy
      121 maadgdfkik cvafe
//
LOCUS       NP_001128572             235 aa            linear   ROD 09-OCT-2023
DEFINITION  interleukin-34 isoform 1 precursor [Mus musculus].
ACCESSION   NP_001128572
VERSION     NP_001128572.1
DBSOURCE    REFSEQ: accession NM_001135100.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 235)
  AUTHORS   Ho A, Ngala B, Yamada C, Garcia C, Duarte C, Akkaoui J, Ciolac D,
            Nusbaum A, Kochen W, Efremova D, Groppa S, Nathanson L, Bissel S,
            Oblak A, Kacena MA and Movila A.
  TITLE     IL-34 exacerbates pathogenic features of Alzheimer's disease and
            calvaria osteolysis in triple transgenic (3x-Tg) female mice
  JOURNAL   Biomed Pharmacother 166, 115435 (2023)
   PUBMED   37666180
  REMARK    GeneRIF: IL-34 exacerbates pathogenic features of Alzheimer's
            disease and calvaria osteolysis in triple transgenic (3x-Tg) female
            mice.
REFERENCE   2  (residues 1 to 235)
  AUTHORS   Zhuang L, Zong X, Yang Q, Fan Q and Tao R.
  TITLE     Interleukin-34-NF-kappaB signaling aggravates myocardial
            ischemic/reperfusion injury by facilitating macrophage recruitment
            and polarization
  JOURNAL   EBioMedicine 95, 104744 (2023)
   PUBMED   37556943
  REMARK    GeneRIF: Interleukin-34-NF-kappaB signaling aggravates myocardial
            ischemic/reperfusion injury by facilitating macrophage recruitment
            and polarization.
REFERENCE   3  (residues 1 to 235)
  AUTHORS   Xie X, Zhang W, Xiao M, Wei T, Qiu Y, Qiu J, Wang H, Qiu Z, Zhang
            S, Pan Y, Mao L, Li Y, Guo B, Yang W, Hu Y, Hu S, Gong Y, Yang J,
            Xiao G, Zhang Y and Bai X.
  TITLE     TREM2 acts as a receptor for IL-34 to suppress acute myeloid
            leukemia in mice
  JOURNAL   Blood 141 (26), 3184-3198 (2023)
   PUBMED   37001042
  REMARK    GeneRIF: TREM2 acts as a receptor for IL-34 to suppress acute
            myeloid leukemia in mice.
REFERENCE   4  (residues 1 to 235)
  AUTHORS   Chae DS, Han S, Lee MK and Kim SW.
  TITLE     BMP-2 Genome-Edited Human MSCs Protect against Cartilage
            Degeneration via Suppression of IL-34 in Collagen-Induced Arthritis
  JOURNAL   Int J Mol Sci 24 (9), 8223 (2023)
   PUBMED   37175932
  REMARK    GeneRIF: BMP-2 Genome-Edited Human MSCs Protect against Cartilage
            Degeneration via Suppression of IL-34 in Collagen-Induced
            Arthritis.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 235)
  AUTHORS   Su Y, Cao Y, Liu C, Xu Q, Li N, Lan M, Li L, Wang K, Zhang Z and
            Meng Q.
  TITLE     Inactivating IL34 promotes regenerating muscle stem cell expansion
            and attenuates Duchenne muscular dystrophy in mouse models
  JOURNAL   Theranostics 13 (8), 2588-2604 (2023)
   PUBMED   37215564
  REMARK    GeneRIF: Inactivating IL34 promotes regenerating muscle stem cell
            expansion and attenuates Duchenne muscular dystrophy in mouse
            models.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 235)
  AUTHORS   Chen Z, Buki K, Vaaraniemi J, Gu G and Vaananen HK.
  TITLE     The critical role of IL-34 in osteoclastogenesis
  JOURNAL   PLoS One 6 (4), e18689 (2011)
   PUBMED   21494622
  REMARK    GeneRIF: This study was to explore the biological function,
            specifically osteoclastogenesis and bone metabolism, of il-34.
            Publication Status: Online-Only
REFERENCE   7  (residues 1 to 235)
  AUTHORS   Chihara T, Suzu S, Hassan R, Chutiwitoonchai N, Hiyoshi M,
            Motoyoshi K, Kimura F and Okada S.
  TITLE     IL-34 and M-CSF share the receptor Fms but are not identical in
            biological activity and signal activation
  JOURNAL   Cell Death Differ 17 (12), 1917-1927 (2010)
   PUBMED   20489731
REFERENCE   8  (residues 1 to 235)
  AUTHORS   Wei S, Nandi S, Chitu V, Yeung YG, Yu W, Huang M, Williams LT, Lin
            H and Stanley ER.
  TITLE     Functional overlap but differential expression of CSF-1 and IL-34
            in their CSF-1 receptor-mediated regulation of myeloid cells
  JOURNAL   J Leukoc Biol 88 (3), 495-505 (2010)
   PUBMED   20504948
  REMARK    GeneRIF: The different spatiotemporal expression of IL-34 and CSF-1
            allows for complementary activation of the CSF-1R in developing and
            adult tissues.
REFERENCE   9  (residues 1 to 235)
  AUTHORS   Baud'huin M, Renault R, Charrier C, Riet A, Moreau A, Brion R,
            Gouin F, Duplomb L and Heymann D.
  TITLE     Interleukin-34 is expressed by giant cell tumours of bone and plays
            a key role in RANKL-induced osteoclastogenesis
  JOURNAL   J Pathol 221 (1), 77-86 (2010)
   PUBMED   20191615
REFERENCE   10 (residues 1 to 235)
  AUTHORS   Lin H, Lee E, Hestir K, Leo C, Huang M, Bosch E, Halenbeck R, Wu G,
            Zhou A, Behrens D, Hollenbaugh D, Linnemann T, Qin M, Wong J, Chu
            K, Doberstein SK and Williams LT.
  TITLE     Discovery of a cytokine and its receptor by functional screening of
            the extracellular proteome
  JOURNAL   Science 320 (5877), 807-811 (2008)
   PUBMED   18467591
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY148512.1, AK008082.1 and AW743837.1.
            
            Transcript Variant: This variant (1) encodes the longer protein
            (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016254.1, SRR7652917.590638.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..235
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 57.68 cM"
     Protein         1..235
                     /product="interleukin-34 isoform 1 precursor"
                     /calculated_mol_wt=24578
     sig_peptide     1..20
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=2205
     Region          28..184
                     /region_name="IL34"
                     /note="Interleukin 34; pfam15036"
                     /db_xref="CDD:434409"
     Site            100
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8R1R4.1)"
     CDS             1..235
                     /gene="Il34"
                     /gene_synonym="2010004A03Rik"
                     /coded_by="NM_001135100.2:584..1291"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS52669.1"
                     /db_xref="GeneID:76527"
                     /db_xref="MGI:MGI:1923777"
ORIGIN      
        1 mpwglawlyc lgilldvalg nenleiwtlt qdkecdltgy lrgklqyknr lqymkhyfpi
       61 nyriavpyeg vlrvanitrl qkahvserel rylwvlvsln atesvmdvll eghpswkylq
      121 evqtllenvq rslmdveigp hveavlslls tpglslklvr pkalldncfr vmellycscc
      181 kqspilkwqd celprlhphs pgslmqctat nvyplsrqtp tslpgspsss hgslp
//
LOCUS       NP_001349212             534 aa            linear   ROD 09-OCT-2023
DEFINITION  CUGBP Elav-like family member 4 isoform 9 [Mus musculus].
ACCESSION   NP_001349212
VERSION     NP_001349212.1
DBSOURCE    REFSEQ: accession NM_001362283.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 534)
  AUTHORS   Salamon I, Park Y, Miskic T, Kopic J, Matteson P, Page NF, Roque A,
            McAuliffe GW, Favate J, Garcia-Forn M, Shah P, Judas M, Millonig
            JH, Kostovic I, De Rubeis S, Hart RP, Krsnik Z and Rasin MR.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    GeneRIF: Celf4 controls mRNA translation underlying synaptic
            development in the prenatal mammalian neocortex.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 534)
  AUTHORS   Shen Y, Zhang C, Xiao K, Liu D and Xie G.
  TITLE     CELF4 regulates spine formation and depression-like behaviors of
            mice
  JOURNAL   Biochem Biophys Res Commun 605, 39-44 (2022)
   PUBMED   35306363
  REMARK    GeneRIF: CELF4 regulates spine formation and depression-like
            behaviors of mice.
REFERENCE   3  (residues 1 to 534)
  AUTHORS   Moreau MX, Saillour Y, Cwetsch AW, Pierani A and Causeret F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   4  (residues 1 to 534)
  AUTHORS   Li C, Li X, Bi Z, Sugino K, Wang G, Zhu T and Liu Z.
  TITLE     Comprehensive transcriptome analysis of cochlear spiral ganglion
            neurons at multiple ages
  JOURNAL   Elife 9, e50491 (2020)
   PUBMED   31913118
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 534)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 534)
  AUTHORS   Ladd AN, Taffet G, Hartley C, Kearney DL and Cooper TA.
  TITLE     Cardiac tissue-specific repression of CELF activity disrupts
            alternative splicing and causes cardiomyopathy
  JOURNAL   Mol Cell Biol 25 (14), 6267-6278 (2005)
   PUBMED   15988035
  REMARK    GeneRIF: CELF protein activity is required for normal alternative
            splicing in the heart in vivo and normal CELF-mediated alternative
            splicing regulation is in turn required for normal cardiac
            function.
REFERENCE   7  (residues 1 to 534)
  AUTHORS   Meins M, Schlickum S, Wilhelm C, Missbach J, Yadav S, Glaser B,
            Grzmil M, Burfeind P and Laccone F.
  TITLE     Identification and characterization of murine Brunol4, a new member
            of the elav/bruno family
  JOURNAL   Cytogenet Genome Res 97 (3-4), 254-260 (2002)
   PUBMED   12438720
  REMARK    GeneRIF: cloning and characterization
REFERENCE   8  (residues 1 to 534)
  AUTHORS   Ladd AN, Charlet N and Cooper TA.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   9  (residues 1 to 534)
  AUTHORS   Good PJ, Chen Q, Warner SJ and Herring DC.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
REFERENCE   10 (residues 1 to 534)
  AUTHORS   Yulug IG, Egan SE, See CG and Fisher EM.
  TITLE     Mapping GRB2, a signal transduction gene in the human and the mouse
  JOURNAL   Genomics 22 (2), 313-318 (1994)
   PUBMED   7806216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121094.8 and AC144938.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.65164.1,
                                           SRR6116558.169242.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..534
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 13.92 cM"
     Protein         1..534
                     /product="CUGBP Elav-like family member 4 isoform 9"
                     /note="CUG-BP- and ETR-3-like factor 4; bruno-like protein
                     4; RNA-binding protein BRUNOL-4; bruno-like 4, RNA binding
                     protein"
                     /calculated_mol_wt=56822
     Region          18..39
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          49..135
                     /region_name="RRM1_CELF3_4_5_6"
                     /note="RNA recognition motif 1 (RRM1) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12632"
                     /db_xref="CDD:410041"
     Site            order(55,57,59..60,63,82,84,86,95..97,99,129,131)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410041"
     Region          121..149
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          151..231
                     /region_name="RRM2_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12635"
                     /db_xref="CDD:410043"
     Site            order(153,155,157..158,161,180,182,184,192..194,196,226,
                     228)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410043"
     Region          239..258
                     /region_name="Necessary for TNNT2 exon 5 inclusion.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          415..>443
                     /region_name="RRM_SF"
                     /note="RNA recognition motif (RRM) superfamily; cl17169"
                     /db_xref="CDD:450164"
     CDS             1..534
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /coded_by="NM_001362283.1:531..2135"
                     /note="isoform 9 is encoded by transcript variant 15"
                     /db_xref="GeneID:108013"
                     /db_xref="MGI:MGI:1932407"
ORIGIN      
        1 myikmatlan gqadnaslst nglgsspgsa ghmnglshsp gnpstipmkd hdaiklfigq
       61 iprnldekdl kplfeefgki yeltvlkdrf tgmhkgcafl tyceresalk aqsalheqkt
      121 lpgmnrpiqv kpadsesrgg ssclrqppsq drklfvgmln kqqseddvrr lfeafgniee
      181 ctilrgpdgn skgcafvkys shaeaqaain alhgsqtmpg assslvvkfa dtdkertmrr
      241 mqqmagqmgm fnpmaipfga ygayaqamqq qaalmasvaq ggylnpmaaf aaaqmqqmaa
      301 lnmnglaaap mtptsggstp pgitapavps ipspigvngf tglppqangq paaeavfang
      361 ihpypaqspt aadplqqaya gvqqyagpay paaygqisqa fpqpppmipq qqregpegcn
      421 lliyhlpqef gdaelmqmfl pfgrhpvpsr cqapscqggq caisssarrl relrqpgqrt
      481 drhpgherlp drheeaqgaa eaaqrrqspv lsaggsvprg rpglaqgrml nglh
//
LOCUS       NP_001394506             426 aa            linear   ROD 09-OCT-2023
DEFINITION  mitogen-activated protein kinase 10 isoform 3 [Mus musculus].
ACCESSION   NP_001394506 XP_017176377
VERSION     NP_001394506.1
DBSOURCE    REFSEQ: accession NM_001407577.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 426)
  AUTHORS   Priego M, Noriega L, Kalinin S, Hoffman LM, Feinstein DL and
            Morfini G.
  TITLE     Genetic deletion of c-Jun amino-terminal kinase 3 (JNK3) modestly
            increases disease severity in a mouse model of multiple sclerosis
  JOURNAL   J Neuroimmunol 382, 578152 (2023)
   PUBMED   37454525
  REMARK    GeneRIF: Genetic deletion of c-Jun amino-terminal kinase 3 (JNK3)
            modestly increases disease severity in a mouse model of multiple
            sclerosis.
REFERENCE   2  (residues 1 to 426)
  AUTHORS   Liu F, Deng Y, Zhao Y, Li Z, Gao J, Zhang Y, Yang X, Liu Y and Xia
            Y.
  TITLE     Time series RNA-seq analysis identifies MAPK10 as a critical gene
            in diabetes mellitus-induced atrial fibrillation in mice
  JOURNAL   J Mol Cell Cardiol 168, 70-82 (2022)
   PUBMED   35489387
  REMARK    GeneRIF: Time series RNA-seq analysis identifies MAPK10 as a
            critical gene in diabetes mellitus-induced atrial fibrillation in
            mice.
REFERENCE   3  (residues 1 to 426)
  AUTHORS   Cunningham JG, Scripter JD, Nti SA and Tucker ES.
  TITLE     Early construction of the thalamocortical axon pathway requires
            c-Jun N-terminal kinase signaling within the ventral forebrain
  JOURNAL   Dev Dyn 251 (3), 459-480 (2022)
   PUBMED   34494344
REFERENCE   4  (residues 1 to 426)
  AUTHORS   Goodwani S, Fernandez C, Acton PJ, Buggia-Prevot V, McReynolds ML,
            Ma J, Hu CH, Hamby ME, Jiang Y, Le K, Soth MJ, Jones P and Ray WJ.
  TITLE     Dual Leucine Zipper Kinase Is Constitutively Active in the Adult
            Mouse Brain and Has Both Stress-Induced and Homeostatic Functions
  JOURNAL   Int J Mol Sci 21 (14), 4849 (2020)
   PUBMED   32659913
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 426)
  AUTHORS   Loughran G, Chou MY, Ivanov IP, Jungreis I, Kellis M, Kiran AM,
            Baranov PV and Atkins JF.
  TITLE     Evidence of efficient stop codon readthrough in four mammalian
            genes
  JOURNAL   Nucleic Acids Res 42 (14), 8928-8938 (2014)
   PUBMED   25013167
REFERENCE   6  (residues 1 to 426)
  AUTHORS   Beier H and Grimm M.
  TITLE     Misreading of termination codons in eukaryotes by natural nonsense
            suppressor tRNAs
  JOURNAL   Nucleic Acids Res 29 (23), 4767-4782 (2001)
   PUBMED   11726686
  REMARK    Review article
REFERENCE   7  (residues 1 to 426)
  AUTHORS   Yang DD, Kuan CY, Whitmarsh AJ, Rincon M, Zheng TS, Davis RJ, Rakic
            P and Flavell RA.
  TITLE     Absence of excitotoxicity-induced apoptosis in the hippocampus of
            mice lacking the Jnk3 gene
  JOURNAL   Nature 389 (6653), 865-870 (1997)
   PUBMED   9349820
REFERENCE   8  (residues 1 to 426)
  AUTHORS   Casanova E, Garate C, Ovalle S, Calvo P and Chinchetru MA.
  TITLE     Identification of four splice variants of the mouse
            stress-activated protein kinase JNK/SAPK alpha-isoform
  JOURNAL   Neuroreport 7 (7), 1320-1324 (1996)
   PUBMED   8817558
REFERENCE   9  (residues 1 to 426)
  AUTHORS   Martin JH, Mohit AA and Miller CA.
  TITLE     Developmental expression in the mouse nervous system of the p493F12
            SAP kinase
  JOURNAL   Brain Res Mol Brain Res 35 (1-2), 47-57 (1996)
   PUBMED   8717339
REFERENCE   10 (residues 1 to 426)
  AUTHORS   Suzuki J, Yoshida S, Chen ZL, Momota Y, Kato K, Hirata A and
            Shiosaka S.
  TITLE     Ontogeny of neuropsin mRNA expression in the mouse brain
  JOURNAL   Neurosci Res 23 (4), 345-351 (1995)
   PUBMED   8602273
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC160244.11, AC123664.15,
            AC137121.9 and AC125252.7.
            
            On Jun 6, 2022 this sequence version replaced XP_017176377.1.
            
            Summary: The protein encoded by this gene is a member of the MAP
            kinase family. MAP kinases act as integration points for multiple
            biochemical signals, and thus are involved in a wide variety of
            cellular processes, such as proliferation, differentiation,
            transcription regulation and development. This kinase is
            specifically expressed in a subset of neurons in the nervous system
            and is activated by threonine and tyrosine phosphorylation.
            Targeted deletion of this gene in mice suggests that it may have a
            role in stress-induced neuronal apoptosis. Alternatively spliced
            transcript variants encoding different isoforms have been found for
            this gene. A recent study provided evidence for translational
            readthrough in this gene, and expression of an additional
            C-terminally extended isoform via the use of an alternative
            in-frame translation termination codon. [provided by RefSeq, Dec
            2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.12259.1,
                                           SRR7652917.93010.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..426
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 49.61 cM"
     Protein         1..426
                     /product="mitogen-activated protein kinase 10 isoform 3"
                     /EC_number="2.7.11.24"
                     /note="JNK3 beta1 protein kinase; JNK3 beta2 protein
                     kinase; MAP kinase 10; MAP kinase p49 3F12; c-Jun
                     N-terminal kinase 3; stress-activated protein kinase JNK3;
                     SAPK/Erk/kinase 2"
                     /calculated_mol_wt=47997
     Region          25..360
                     /region_name="STKc_JNK"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     c-Jun N-terminal Kinase; cd07850"
                     /db_xref="CDD:270840"
     Site            order(32..38,40,53,55,72,86,108..114,116..117,151,153,
                     155..156,158,168..169,172,183,185..188,190,227)
                     /site_type="active"
                     /db_xref="CDD:270840"
     Site            order(32..38,40,53,55,86,108..114,158,168)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270840"
     Site            order(72,116,151,153,172,183,185..188,190,227)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270840"
     Site            order(112,118,127,130,159..163,323..324,326,329)
                     /site_type="other"
                     /note="KIM docking site [polypeptide binding]"
                     /db_xref="CDD:270840"
     Site            order(168..178,182..190)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270840"
     CDS             1..426
                     /gene="Mapk10"
                     /gene_synonym="C230008H04Rik; JNK3; JNK3B1; JNK3B2;
                     p493F12; p54bSAPK; SAPK(beta); Serk2"
                     /coded_by="NM_001407577.1:951..2231"
                     /note="isoform 3 is encoded by transcript variant 12"
                     /db_xref="GeneID:26414"
                     /db_xref="MGI:MGI:1346863"
ORIGIN      
        1 mskskvdnqf ysvevgdstf tvlkryqnlk pigsgaqgiv caaydavldr nvaikklsrp
       61 fqnqthakra yrelvlmkcv nhkniislln vftpqktlee fqdvylvmel mdanlcqviq
      121 meldhermsy llyqmlcgik hlhsagiihr dlkpsnivvk sdctlkildf glartagtsf
      181 mmtpyvvtry yrapevilgm gykenvdiws vgcimgemvr hkilfpgrdy idqwnkvieq
      241 lgtpcpefmk klqptvrnyv enrpkyaglt fpklfpdslf padsehnklk asqardllsk
      301 mlvidpakri svddalqhpy invwydpaev eapppqiydk qlderehtie ewkeliykev
      361 mnseektkng vvkgqpspsg aavnsseslp psssvndiss mstdqtlasd tdssleasag
      421 plgccr
//
LOCUS       NP_001348622             515 aa            linear   ROD 09-OCT-2023
DEFINITION  nuclear respiratory factor 1 isoform f [Mus musculus].
ACCESSION   NP_001348622 XP_017176932
VERSION     NP_001348622.1
DBSOURCE    REFSEQ: accession NM_001361693.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 515)
  AUTHORS   Cheng C, Tian Y, Yang R, Guo W, Xiao K, Zhang F, Tian J, Deng Z,
            Yang W, Yang H and Zhou Z.
  TITLE     miR-5581 Contributes to Osteoarthritis by Targeting NRF1 to Disturb
            the Proliferation and Functions of Chondrocytes
  JOURNAL   Am J Pathol 193 (9), 1234-1247 (2023)
   PUBMED   37611970
  REMARK    GeneRIF: miR-5581 Contributes to Osteoarthritis by Targeting NRF1
            to Disturb the Proliferation and Functions of Chondrocytes.
REFERENCE   2  (residues 1 to 515)
  AUTHORS   Meng Z, Liang B, Wu Y, Liu C, Wang H, Du Y, Gan L, Gao E, Lau WB,
            Christopher TA, Lopez BL, Koch WJ, Ma X, Zhao F, Wang Y and Zhao J.
  TITLE     Hypoadiponectinemia-induced upregulation of microRNA449b
            downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury
            in diabetic mice
  JOURNAL   J Mol Cell Cardiol 182, 1-14 (2023)
   PUBMED   37437402
  REMARK    GeneRIF: Hypoadiponectinemia-induced upregulation of microRNA449b
            downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury
            in diabetic mice.
REFERENCE   3  (residues 1 to 515)
  AUTHORS   Zhao T, Zhang J, Lei H, Meng Y, Cheng H, Zhao Y, Geng G, Mu C, Chen
            L, Liu Q, Luo Q, Zhang C, Long Y, Su J, Wang Y, Li Z, Sun J, Chen
            G, Li Y, Liao X, Shang Y, Hu G, Chen Q and Zhu Y.
  TITLE     NRF1-mediated mitochondrial biogenesis antagonizes innate antiviral
            immunity
  JOURNAL   EMBO J 42 (16), e113258 (2023)
   PUBMED   37409632
  REMARK    GeneRIF: NRF1-mediated mitochondrial biogenesis antagonizes innate
            antiviral immunity.
REFERENCE   4  (residues 1 to 515)
  AUTHORS   Akl MG, Baccetto R, Stebbings BM, Li L and Widenmaier SB.
  TITLE     Euglycemia is affected by stress defense factor hepatocyte NRF1,
            but not NRF2
  JOURNAL   Biochem Biophys Res Commun 668, 96-103 (2023)
   PUBMED   37245295
  REMARK    GeneRIF: Euglycemia is affected by stress defense factor hepatocyte
            NRF1, but not NRF2.
REFERENCE   5  (residues 1 to 515)
  AUTHORS   Akl MG, Li L, Baccetto R, Phanse S, Zhang Q, Trites MJ, McDonald S,
            Aoki H, Babu M and Widenmaier SB.
  TITLE     Complementary gene regulation by NRF1 and NRF2 protects against
            hepatic cholesterol overload
  JOURNAL   Cell Rep 42 (4), 112399 (2023)
   PUBMED   37060561
  REMARK    GeneRIF: Complementary gene regulation by NRF1 and NRF2 protects
            against hepatic cholesterol overload.
            Erratum:[Cell Rep. 2023 Jul 25;42(7):112872. PMID: 37454293]
REFERENCE   6  (residues 1 to 515)
  AUTHORS   Carmona MC, Iglesias R, Obregon MJ, Darlington GJ, Villarroya F and
            Giralt M.
  TITLE     Mitochondrial biogenesis and thyroid status maturation in brown fat
            require CCAAT/enhancer-binding protein alpha
  JOURNAL   J Biol Chem 277 (24), 21489-21498 (2002)
   PUBMED   11940593
REFERENCE   7  (residues 1 to 515)
  AUTHORS   Huo L and Scarpulla RC.
  TITLE     Mitochondrial DNA instability and peri-implantation lethality
            associated with targeted disruption of nuclear respiratory factor 1
            in mice
  JOURNAL   Mol Cell Biol 21 (2), 644-654 (2001)
   PUBMED   11134350
REFERENCE   8  (residues 1 to 515)
  AUTHORS   Schaefer L, Engman H and Miller JB.
  TITLE     Coding sequence, chromosomal localization, and expression pattern
            of Nrf1: the mouse homolog of Drosophila erect wing
  JOURNAL   Mamm Genome 11 (2), 104-110 (2000)
   PUBMED   10656923
REFERENCE   9  (residues 1 to 515)
  AUTHORS   Huo L and Scarpulla RC.
  TITLE     Multiple 5'-untranslated exons in the nuclear respiratory factor 1
            gene span 47 kb and contribute to transcript heterogeneity and
            translational efficiency
  JOURNAL   Gene 233 (1-2), 213-224 (1999)
   PUBMED   10375638
REFERENCE   10 (residues 1 to 515)
  AUTHORS   Virbasius CA, Virbasius JV and Scarpulla RC.
  TITLE     NRF-1, an activator involved in nuclear-mitochondrial interactions,
            utilizes a new DNA-binding domain conserved in a family of
            developmental regulators
  JOURNAL   Genes Dev 7 (12A), 2431-2445 (1993)
   PUBMED   8253388
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153632.2.
            
            On Mar 29, 2018 this sequence version replaced XP_017176932.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.41920.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849390
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..515
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 12.47 cM"
     Protein         1..515
                     /product="nuclear respiratory factor 1 isoform f"
                     /note="NRF-1; alpha-pal; alpha palindromic-binding
                     protein"
                     /calculated_mol_wt=54726
     Region          87..295
                     /region_name="Nrf1_DNA-bind"
                     /note="NLS-binding and DNA-binding and dimerization
                     domains of Nrf1; pfam10491"
                     /db_xref="CDD:402218"
     Region          462..514
                     /region_name="Nrf1_activ_bdg"
                     /note="Nrf1 activator activation site binding domain;
                     pfam10492"
                     /db_xref="CDD:431313"
     CDS             1..515
                     /gene="Nrf1"
                     /gene_synonym="D6Ertd415e"
                     /coded_by="NM_001361693.2:1815..3362"
                     /note="isoform f is encoded by transcript variant 8"
                     /db_xref="GeneID:18181"
                     /db_xref="MGI:MGI:1332235"
ORIGIN      
        1 meehgvtqte hmatieahav aqqvqqvhva tytehsmlsa dedspssped tsyddsdiln
       61 staadevtah laaavlgikp rashilgpvg maaaaavatg kkrkrphvfe snpsirkrqq
      121 trllrklrat ldeyttrvgq qaivlcisps kpnpvfkvfg aaplenvvrk yksmiledle
      181 salaehapap qevnselppl tidgipvsvd kmtqaqlraf ipemlkystg rgkpgwgkes
      241 ckpiwwpedi pwanvrsdvr teeqkqrvsw tqalrtivkn cykqhgredl lyafedqqtq
      301 tqattthsia hlvpsqtvvq tfsnpdgtvs liqvgtgatv atladaselp ttvtvaqvny
      361 savadgeveq nwatlqggem tiqttqasea tqavaslaea avaasqemqq gatvtmalns
      421 eaaahavatl aeatlqgggq ivlsgetaaa vgaltgvqda nglvqipvsm yqtvvtslaq
      481 gngpvqvama pvttrisdsa vtmdgqavev vtleq
//
LOCUS       NP_001351350             645 aa            linear   ROD 09-OCT-2023
DEFINITION  pro-neuregulin-1, membrane-bound isoform isoform 2 [Mus musculus].
ACCESSION   NP_001351350 XP_006509143
VERSION     NP_001351350.1
DBSOURCE    REFSEQ: accession NM_001364421.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 645)
  AUTHORS   Mikami Y, Iwase F, Ohshima D, Tomida T and Adachi-Akahane S.
  TITLE     Compensatory role of neuregulin-1 in diabetic cardiomyopathy
  JOURNAL   J Pharmacol Sci 153 (3), 130-141 (2023)
   PUBMED   37770154
  REMARK    GeneRIF: Compensatory role of neuregulin-1 in diabetic
            cardiomyopathy.
REFERENCE   2  (residues 1 to 645)
  AUTHORS   Qiao XY, Wang Y, Zhang W, Li Q, Liu C, Dao JJ, Qiao CM, Cui C, Shen
            YQ and Zhao WJ.
  TITLE     Involvement of CXCL10 in Neuronal Damage under the Condition of
            Spinal Cord Injury and the Potential Therapeutic Effect of Nrg1
  JOURNAL   J Integr Neurosci 22 (4), 96 (2023)
   PUBMED   37519170
  REMARK    GeneRIF: Involvement of CXCL10 in Neuronal Damage under the
            Condition of Spinal Cord Injury and the Potential Therapeutic
            Effect of Nrg1.
REFERENCE   3  (residues 1 to 645)
  AUTHORS   Liu H, Lu P, He S, Luo Y, Fang Y, Benkaci S, Wu B, Wang Y and Zhou
            B.
  TITLE     beta-Catenin regulates endocardial cushion growth by suppressing
            p21
  JOURNAL   Life Sci Alliance 6 (9), e202302163 (2023)
   PUBMED   37385754
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 645)
  AUTHORS   Kong L, Hassinan CW, Gerstner F, Buettner JM, Petigrow JB, Valdivia
            DO, Chan-Cortes MH, Mistri A, Cao A, McGaugh SA, Denton M, Brown S,
            Ross J, Schwab MH, Simon CM and Sumner CJ.
  TITLE     Boosting neuregulin 1 type-III expression hastens SMA motor axon
            maturation
  JOURNAL   Acta Neuropathol Commun 11 (1), 53 (2023)
   PUBMED   36997967
  REMARK    GeneRIF: Boosting neuregulin 1 type-III expression hastens SMA
            motor axon maturation.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 645)
  AUTHORS   Zhang X, Xiao G, Johnson C, Cai Y, Horowitz ZK, Mennicke C, Coffey
            R, Haider M, Threadgill D, Eliscu R, Oldham MC, Greenbaum A and
            Ghashghaei HT.
  TITLE     Bulk and mosaic deletions of Egfr reveal regionally defined
            gliogenesis in the developing mouse forebrain
  JOURNAL   iScience 26 (3), 106242 (2023)
   PUBMED   36915679
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 645)
  AUTHORS   Gassmann M, Casagranda F, Orioli D, Simon H, Lai C, Klein R and
            Lemke G.
  TITLE     Aberrant neural and cardiac development in mice lacking the ErbB4
            neuregulin receptor
  JOURNAL   Nature 378 (6555), 390-394 (1995)
   PUBMED   7477376
REFERENCE   7  (residues 1 to 645)
  AUTHORS   Meyer,D. and Birchmeier,C.
  TITLE     Multiple essential functions of neuregulin in development
  JOURNAL   Nature 378 (6555), 386-390 (1995)
   PUBMED   7477375
  REMARK    Erratum:[Nature 1995 Dec 14;378(6558):753]
REFERENCE   8  (residues 1 to 645)
  AUTHORS   Moscoso LM, Chu GC, Gautam M, Noakes PG, Merlie JP and Sanes JR.
  TITLE     Synapse-associated expression of an acetylcholine receptor-inducing
            protein, ARIA/heregulin, and its putative receptors, ErbB2 and
            ErbB3, in developing mammalian muscle
  JOURNAL   Dev Biol 172 (1), 158-169 (1995)
   PUBMED   7589796
REFERENCE   9  (residues 1 to 645)
  AUTHORS   Yang Y, Spitzer E, Meyer D, Sachs M, Niemann C, Hartmann G, Weidner
            KM, Birchmeier C and Birchmeier W.
  TITLE     Sequential requirement of hepatocyte growth factor and neuregulin
            in the morphogenesis and differentiation of the mammary gland
  JOURNAL   J Cell Biol 131 (1), 215-226 (1995)
   PUBMED   7559778
REFERENCE   10 (residues 1 to 645)
  AUTHORS   Ho WH, Armanini MP, Nuijens A, Phillips HS and Osheroff PL.
  TITLE     Sensory and motor neuron-derived factor. A novel heregulin variant
            highly expressed in sensory and motor neurons
  JOURNAL   J Biol Chem 270 (24), 14523-14532 (1995)
   PUBMED   7782315
  REMARK    Erratum:[J Biol Chem. 1995 Nov 3;270(44):26722. PMID: 7592900]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC136147.4, AC132407.3 and AC127374.4.
            
            On Jun 16, 2018 this sequence version replaced XP_006509143.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY648976.1, SRR14995047.521323.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..645
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 18.75 cM"
     Protein         1..645
                     /product="pro-neuregulin-1, membrane-bound isoform isoform
                     2"
                     /note="heregulin; type III neuregulin 1; type I neuregulin
                     1; pro-neuregulin-1, membrane-bound isoform"
                     /calculated_mol_wt=71251
     Region          1..52
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6DR98.1)"
     Region          37..129
                     /region_name="Ig_Pro_neuregulin-1"
                     /note="Immunoglobulin (Ig)-like domain found in neuregulin
                     (NRG)-1; cd05895"
                     /db_xref="CDD:409476"
     Region          37..43
                     /region_name="putative Ig strand A"
                     /note="putative Ig strand A [structural motif]"
                     /db_xref="CDD:409476"
     Region          51..59
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409476"
     Region          66..71
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409476"
     Region          85..90
                     /region_name="putative Ig strand D"
                     /note="putative Ig strand D [structural motif]"
                     /db_xref="CDD:409476"
     Region          95..99
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409476"
     Region          109..114
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409476"
     Region          121..129
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409476"
     Region          139..175
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6DR98.1)"
     Region          190..220
                     /region_name="EGF"
                     /note="EGF-like domain; pfam00008"
                     /db_xref="CDD:394967"
     Site            248..268
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6DR98.1)"
     Region          272..627
                     /region_name="Neuregulin"
                     /note="Neuregulin family; pfam02158"
                     /db_xref="CDD:426627"
     Region          340..364
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6DR98.1)"
     Region          380..406
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6DR98.1)"
     Region          433..463
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6DR98.1)"
     Region          531..593
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6DR98.1)"
     CDS             1..645
                     /gene="Nrg1"
                     /gene_synonym="6030402G23Rik; ARIA; D230005F13Rik; GGF;
                     GGFII; Hgl; HRG; HRGalpha; NDF; Pro-NRG1; SMDF"
                     /coded_by="NM_001364421.2:396..2333"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS90385.1"
                     /db_xref="GeneID:211323"
                     /db_xref="MGI:MGI:96083"
ORIGIN      
        1 mserkegrgk gkgkkkdrgs rgkpapaegd pspalpprlk emksqesaag sklvlrcets
       61 seysslrfkw fkngnelnrr nkpqnvkiqk kpgkselrin kasladsgey mckvisklgn
      121 dsasanitiv esndlttgms asterpyvss espirisvst egantsssts tsttgtshli
      181 kcaekektfc vnggecfmvk dlsnpsrylc kcpneftgdr cqnyvmasfy khlgiefmea
      241 eelyqkrvlt itgiciallv vgimcvvayc ktkkqrqklh drlrqslrse rnnmvniang
      301 phhpnpppen vqlvnqyvsk nvissehive revetsfsts hytstahhst tvtqtpshsw
      361 snghtesiis eshsvimmss vensrhsspa ggprgrlhgl ggprecnsfl rharetpdsy
      421 rdsphseryv samttparms pvdfhtpssp ksppsemspp vssmtvsmps vavspfveee
      481 rplllvtppr lrekkydhhp qqlnsfhhnp ahqstslpps plrivedeey ettqeyepiq
      541 epikkvtnsr rakrtkpngh ianrlemdsn pssvssnses etedervged tpflgiqnpl
      601 aaslevapaf rlaesrtnpa grfstqeelq arlssvianq dpiav
//
LOCUS       NP_001407810            1256 aa            linear   ROD 09-OCT-2023
DEFINITION  period circadian protein homolog 2 isoform 2 [Mus musculus].
ACCESSION   NP_001407810 XP_006529312
VERSION     NP_001407810.1
DBSOURCE    REFSEQ: accession NM_001420881.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1256)
  AUTHORS   Millius A, Yamada RG, Fujishima H, Maeda K, Standley DM, Sumiyama
            K, Perrin D and Ueda HR.
  TITLE     Circadian ribosome profiling reveals a role for the Period2
            upstream open reading frame in sleep
  JOURNAL   Proc Natl Acad Sci U S A 120 (40), e2214636120 (2023)
   PUBMED   37769257
  REMARK    GeneRIF: Circadian ribosome profiling reveals a role for the
            Period2 upstream open reading frame in sleep.
REFERENCE   2  (residues 1 to 1256)
  AUTHORS   Sayson LV, Lee HJ, Ortiz DM, Kim M, Custodio RJP, Lee CH, Lee YS,
            Cheong JH and Kim HJ.
  TITLE     The differential vulnerabilities of Per2 knockout mice to the
            addictive properties of methamphetamine and cocaine
  JOURNAL   Prog Neuropsychopharmacol Biol Psychiatry 126, 110782 (2023)
   PUBMED   37141987
  REMARK    GeneRIF: The differential vulnerabilities of Per2 knockout mice to
            the addictive properties of methamphetamine and cocaine.
REFERENCE   3  (residues 1 to 1256)
  AUTHORS   Bora G, Onel T, Yildirim E and Yaba A.
  TITLE     Circadian regulation of mTORC1 signaling via Per2 dependent
            mechanism disrupts folliculogenesis and oocyte maturation in female
            mice
  JOURNAL   J Mol Histol 54 (3), 217-229 (2023)
   PUBMED   37162693
  REMARK    GeneRIF: Circadian regulation of mTORC1 signaling via Per2
            dependent mechanism disrupts folliculogenesis and oocyte maturation
            in female mice.
REFERENCE   4  (residues 1 to 1256)
  AUTHORS   Guo L, Cen H, Weng J, He Y, Guo X, He D, Liu K, Duan S, Yang J,
            Zhang X, Qin Z, Wan Y, Chen Z and Wu B.
  TITLE     PER2 integrates circadian disruption and pituitary tumorigenesis
  JOURNAL   Theranostics 13 (8), 2657-2672 (2023)
   PUBMED   37215573
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1256)
  AUTHORS   Wendrich KS, Azimi H, Ripperger JA, Ravussin Y, Rainer G and
            Albrecht U.
  TITLE     Deletion of the Circadian Clock Gene Per2 in the Whole Body, but
            Not in Neurons or Astroglia, Affects Sleep in Response to Sleep
            Deprivation
  JOURNAL   Clocks Sleep 5 (2), 204-225 (2023)
   PUBMED   37092429
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1256)
  AUTHORS   Takumi T, Taguchi K, Miyake S, Sakakida Y, Takashima N, Matsubara
            C, Maebayashi Y, Okumura K, Takekida S, Yamamoto S, Yagita K, Yan
            L, Young MW and Okamura H.
  TITLE     A light-independent oscillatory gene mPer3 in mouse SCN and OVLT
  JOURNAL   EMBO J 17 (16), 4753-4759 (1998)
   PUBMED   9707434
REFERENCE   7  (residues 1 to 1256)
  AUTHORS   Sassone-Corsi,P.
  TITLE     Molecular clocks: mastering time by gene regulation
  JOURNAL   Nature 392 (6679), 871-874 (1998)
   PUBMED   9582067
REFERENCE   8  (residues 1 to 1256)
  AUTHORS   Takumi T, Matsubara C, Shigeyoshi Y, Taguchi K, Yagita K,
            Maebayashi Y, Sakakida Y, Okumura K, Takashima N and Okamura H.
  TITLE     A new mammalian period gene predominantly expressed in the
            suprachiasmatic nucleus
  JOURNAL   Genes Cells 3 (3), 167-176 (1998)
   PUBMED   9619629
REFERENCE   9  (residues 1 to 1256)
  AUTHORS   Albrecht U, Sun ZS, Eichele G and Lee CC.
  TITLE     A differential response of two putative mammalian circadian
            regulators, mper1 and mper2, to light
  JOURNAL   Cell 91 (7), 1055-1064 (1997)
   PUBMED   9428527
REFERENCE   10 (residues 1 to 1256)
  AUTHORS   Shearman LP, Zylka MJ, Weaver DR, Kolakowski LF Jr and Reppert SM.
  TITLE     Two period homologs: circadian expression and photic regulation in
            the suprachiasmatic nuclei
  JOURNAL   Neuron 19 (6), 1261-1269 (1997)
   PUBMED   9427249
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC109199.10 and AC110510.6.
            
            On May 9, 2023 this sequence version replaced XP_006529312.1.
            
            Summary: This gene is a member of the Period family of genes and is
            expressed in a circadian pattern in the suprachiasmatic nucleus,
            the primary circadian pacemaker in the mammalian brain. Genes in
            this family encode components of the circadian rhythms of locomotor
            activity, metabolism, and behavior. This gene is upregulated by
            Clock/Arntl heterodimers but then represses this upregulation in a
            feedback loop using Per/Cry heterodimers to interact with
            Clock/Arntl. Polymorphisms in this gene may increase the risk of
            getting certain cancers and have been linked to sleep disorders.
            [provided by RefSeq, Jan 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219380.30240.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1256
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 46.13 cM"
     Protein         1..1256
                     /product="period circadian protein homolog 2 isoform 2"
                     /note="period 2; period circadian protein homolog 2;
                     circadian clock protein PERIOD 2; period homolog 2"
                     /calculated_mol_wt=135682
     Region          1..60
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O54943.3)"
     Region          108..117
                     /region_name="Nuclear export signal 1.
                     /evidence=ECO:0000269|PubMed:11889036"
                     /note="propagated from UniProtKB/Swiss-Prot (O54943.3)"
     Region          305..309
                     /region_name="LXXLL"
                     /note="propagated from UniProtKB/Swiss-Prot (O54943.3)"
     Region          343..427
                     /region_name="PAS_3"
                     /note="PAS fold; pfam08447"
                     /db_xref="CDD:430001"
     Site            order(343,347,353,366..369,397,402)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:238075"
     Site            order(363,367,375,378..379,409,411)
                     /site_type="other"
                     /note="heme pocket [chemical binding]"
                     /db_xref="CDD:238075"
     Region          <444..>981
                     /region_name="PRK10263"
                     /note="DNA translocase FtsK; Provisional"
                     /db_xref="CDD:236669"
     Region          459..468
                     /region_name="Nuclear export signal 2.
                     /evidence=ECO:0000269|PubMed:11889036"
                     /note="propagated from UniProtKB/Swiss-Prot (O54943.3)"
     Region          470..564
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O54943.3)"
     Region          477..481
                     /region_name="Important for protein stability.
                     /evidence=ECO:0000250|UniProtKB:Q9Z301"
                     /note="propagated from UniProtKB/Swiss-Prot (O54943.3)"
     Region          509..708
                     /region_name="CSNK1E binding domain.
                     /evidence=ECO:0000269|PubMed:14701732"
                     /note="propagated from UniProtKB/Swiss-Prot (O54943.3)"
     Site            524
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:16097765; propagated from
                     UniProtKB/Swiss-Prot (O54943.3)"
     Site            527
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:16097765; propagated from
                     UniProtKB/Swiss-Prot (O54943.3)"
     Site            530
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:16097765; propagated from
                     UniProtKB/Swiss-Prot (O54943.3)"
     Site            537
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:16097765; propagated from
                     UniProtKB/Swiss-Prot (O54943.3)"
     Site            543
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:16097765; propagated from
                     UniProtKB/Swiss-Prot (O54943.3)"
     Site            553
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000269|PubMed:16097765; propagated from
                     UniProtKB/Swiss-Prot (O54943.3)"
     Region          616..637
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O54943.3)"
     Site            658
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O15055; propagated from
                     UniProtKB/Swiss-Prot (O54943.3)"
     Site            692
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (O54943.3)"
     Site            696
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (O54943.3)"
     Site            705
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:16097765; propagated from
                     UniProtKB/Swiss-Prot (O54943.3)"
     Region          756..831
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O54943.3)"
     Site            757
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:16097765; propagated from
                     UniProtKB/Swiss-Prot (O54943.3)"
     Site            762
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:16097765; propagated from
                     UniProtKB/Swiss-Prot (O54943.3)"
     Region          777..793
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000269|PubMed:11889036"
                     /note="propagated from UniProtKB/Swiss-Prot (O54943.3)"
     Region          <789..1037
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Site            857
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000269|PubMed:16097765; propagated from
                     UniProtKB/Swiss-Prot (O54943.3)"
     Region          881..1066
                     /region_name="Interaction with PPARG.
                     /evidence=ECO:0000269|PubMed:21035761"
                     /note="propagated from UniProtKB/Swiss-Prot (O54943.3)"
     Site            938
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:16097765; propagated from
                     UniProtKB/Swiss-Prot (O54943.3)"
     Site            963
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000269|PubMed:16097765; propagated from
                     UniProtKB/Swiss-Prot (O54943.3)"
     Site            970
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:16097765; propagated from
                     UniProtKB/Swiss-Prot (O54943.3)"
     Region          982..989
                     /region_name="Nuclear export signal 3.
                     /evidence=ECO:0000269|PubMed:11889036"
                     /note="propagated from UniProtKB/Swiss-Prot (O54943.3)"
     Region          993..1043
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O54943.3)"
     Region          1039..1209
                     /region_name="Period_C"
                     /note="Period protein 2/3C-terminal region; pfam12114"
                     /db_xref="CDD:432341"
     Region          1050..1054
                     /region_name="LXXLL"
                     /note="propagated from UniProtKB/Swiss-Prot (O54943.3)"
     Region          1069..1114
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O54943.3)"
     Site            1125
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:16097765; propagated from
                     UniProtKB/Swiss-Prot (O54943.3)"
     Region          1156..1256
                     /region_name="CRY binding domain.
                     /evidence=ECO:0000250|UniProtKB:Q9Z301"
                     /note="propagated from UniProtKB/Swiss-Prot (O54943.3)"
     Region          1223..1256
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O54943.3)"
     CDS             1..1256
                     /gene="Per2"
                     /gene_synonym="mKIAA0347; mPer2"
                     /coded_by="NM_001420881.1:153..3923"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="GeneID:18627"
                     /db_xref="MGI:MGI:1195265"
ORIGIN      
        1 mngyvdfsps ptsptkepga pqptqavlqe dvdmssgssg nencstgrds qgsdcddngk
       61 elrmlvessn thpspddafr lmmteaehnp stsgcseqsa kadahkelir tlkelkvhlp
      121 adkkakgkas tlatlkyalr svkqvkanee yyqllmsses qpcsvdvpsy smeqvegits
      181 eyivknadmf avavslvsgk ilyisnqvas ifhckkdafs dakfveflap hdvsvfhsyt
      241 tpyklppwsv csgldsftqe cmeeksffcr vsvgkhhene iryqpfrmtp ylvkvqeqqg
      301 aesqlcclll aervhsgyea prippekrif ttthtpnclf qavderavpl lgylpqdlie
      361 tpvlvqlhps drplmlaihk kilqaggqpf dyspirfrtr ngeyitldts wssfinpwsr
      421 kisfiigrhk vrvgplnedv faaspcpeek tphpsvqelt eqihrllmqp vphsgssgyg
      481 slgsngsheh lmsqtsssds ngqeeshrrr sgifktsgki qtkshvshes ggqkeasvae
      541 mqssppaqvk avttierdss gaslpkasfp eelayknqpp csyqqiscld svirylescs
      601 eaatlkrkce fpanipsrka tvspglhsge aarpskvtsh tevsahlssl tlpgkaesvv
      661 sltsqcsyss tivhvgdkkp qpeletvedm asgpesldga agglsqekgp lqklgltkev
      721 laahtqreeq gflqrfrevs rlsalqahcq nylqersraq asdrglrnts glesswkktg
      781 knrklkskrv ktrdssestg sggpvshrpp lmglnataws psdtsqsscp sapfptavpa
      841 yplpvfqapg ivstpgtvva ppaathtgft mpvvpmgtqp efavqplpfa aplapvmafm
      901 lpsypfppat pnlpqaflps qphfpahptl aseitpasqa efpsrtstlr qpcacpvtpp
      961 agtvalgras pplfqsrgss plqlnllqle eapegstgaa gtlgttgtaa sgldctsgts
     1021 rdrqpkappt cnepsdtqns daistssdll nlllgedlcs atgsalsrsg asatsdslgs
     1081 sslgfgtsqs gagssdtsht skyfgsidss ennhkakmip dteeseqfik yvlqdpiwll
     1141 mantddsimm tyqlpsrdlq avlkedqekl kllqrsqprf tegqrrelre vhpwvhtggl
     1201 ptaidvtgcv yceseekgni clpyeedsps pglcdtseak eeegeqltgp rieaqt
//
LOCUS       NP_001394521             384 aa            linear   ROD 09-OCT-2023
DEFINITION  mitogen-activated protein kinase 10 isoform 5 [Mus musculus].
ACCESSION   NP_001394521 XP_017176380
VERSION     NP_001394521.1
DBSOURCE    REFSEQ: accession NM_001407592.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 384)
  AUTHORS   Priego M, Noriega L, Kalinin S, Hoffman LM, Feinstein DL and
            Morfini G.
  TITLE     Genetic deletion of c-Jun amino-terminal kinase 3 (JNK3) modestly
            increases disease severity in a mouse model of multiple sclerosis
  JOURNAL   J Neuroimmunol 382, 578152 (2023)
   PUBMED   37454525
  REMARK    GeneRIF: Genetic deletion of c-Jun amino-terminal kinase 3 (JNK3)
            modestly increases disease severity in a mouse model of multiple
            sclerosis.
REFERENCE   2  (residues 1 to 384)
  AUTHORS   Liu F, Deng Y, Zhao Y, Li Z, Gao J, Zhang Y, Yang X, Liu Y and Xia
            Y.
  TITLE     Time series RNA-seq analysis identifies MAPK10 as a critical gene
            in diabetes mellitus-induced atrial fibrillation in mice
  JOURNAL   J Mol Cell Cardiol 168, 70-82 (2022)
   PUBMED   35489387
  REMARK    GeneRIF: Time series RNA-seq analysis identifies MAPK10 as a
            critical gene in diabetes mellitus-induced atrial fibrillation in
            mice.
REFERENCE   3  (residues 1 to 384)
  AUTHORS   Cunningham JG, Scripter JD, Nti SA and Tucker ES.
  TITLE     Early construction of the thalamocortical axon pathway requires
            c-Jun N-terminal kinase signaling within the ventral forebrain
  JOURNAL   Dev Dyn 251 (3), 459-480 (2022)
   PUBMED   34494344
REFERENCE   4  (residues 1 to 384)
  AUTHORS   Goodwani S, Fernandez C, Acton PJ, Buggia-Prevot V, McReynolds ML,
            Ma J, Hu CH, Hamby ME, Jiang Y, Le K, Soth MJ, Jones P and Ray WJ.
  TITLE     Dual Leucine Zipper Kinase Is Constitutively Active in the Adult
            Mouse Brain and Has Both Stress-Induced and Homeostatic Functions
  JOURNAL   Int J Mol Sci 21 (14), 4849 (2020)
   PUBMED   32659913
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 384)
  AUTHORS   Loughran G, Chou MY, Ivanov IP, Jungreis I, Kellis M, Kiran AM,
            Baranov PV and Atkins JF.
  TITLE     Evidence of efficient stop codon readthrough in four mammalian
            genes
  JOURNAL   Nucleic Acids Res 42 (14), 8928-8938 (2014)
   PUBMED   25013167
REFERENCE   6  (residues 1 to 384)
  AUTHORS   Beier H and Grimm M.
  TITLE     Misreading of termination codons in eukaryotes by natural nonsense
            suppressor tRNAs
  JOURNAL   Nucleic Acids Res 29 (23), 4767-4782 (2001)
   PUBMED   11726686
  REMARK    Review article
REFERENCE   7  (residues 1 to 384)
  AUTHORS   Yang DD, Kuan CY, Whitmarsh AJ, Rincon M, Zheng TS, Davis RJ, Rakic
            P and Flavell RA.
  TITLE     Absence of excitotoxicity-induced apoptosis in the hippocampus of
            mice lacking the Jnk3 gene
  JOURNAL   Nature 389 (6653), 865-870 (1997)
   PUBMED   9349820
REFERENCE   8  (residues 1 to 384)
  AUTHORS   Casanova E, Garate C, Ovalle S, Calvo P and Chinchetru MA.
  TITLE     Identification of four splice variants of the mouse
            stress-activated protein kinase JNK/SAPK alpha-isoform
  JOURNAL   Neuroreport 7 (7), 1320-1324 (1996)
   PUBMED   8817558
REFERENCE   9  (residues 1 to 384)
  AUTHORS   Martin JH, Mohit AA and Miller CA.
  TITLE     Developmental expression in the mouse nervous system of the p493F12
            SAP kinase
  JOURNAL   Brain Res Mol Brain Res 35 (1-2), 47-57 (1996)
   PUBMED   8717339
REFERENCE   10 (residues 1 to 384)
  AUTHORS   Suzuki J, Yoshida S, Chen ZL, Momota Y, Kato K, Hirata A and
            Shiosaka S.
  TITLE     Ontogeny of neuropsin mRNA expression in the mouse brain
  JOURNAL   Neurosci Res 23 (4), 345-351 (1995)
   PUBMED   8602273
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC160244.11, AC123664.15,
            AC137121.9 and AC125252.7.
            
            On Jun 6, 2022 this sequence version replaced XP_017176380.1.
            
            Summary: The protein encoded by this gene is a member of the MAP
            kinase family. MAP kinases act as integration points for multiple
            biochemical signals, and thus are involved in a wide variety of
            cellular processes, such as proliferation, differentiation,
            transcription regulation and development. This kinase is
            specifically expressed in a subset of neurons in the nervous system
            and is activated by threonine and tyrosine phosphorylation.
            Targeted deletion of this gene in mice suggests that it may have a
            role in stress-induced neuronal apoptosis. Alternatively spliced
            transcript variants encoding different isoforms have been found for
            this gene. A recent study provided evidence for translational
            readthrough in this gene, and expression of an additional
            C-terminally extended isoform via the use of an alternative
            in-frame translation termination codon. [provided by RefSeq, Dec
            2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.140796.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..384
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 49.61 cM"
     Protein         1..384
                     /product="mitogen-activated protein kinase 10 isoform 5"
                     /EC_number="2.7.11.24"
                     /note="JNK3 beta1 protein kinase; JNK3 beta2 protein
                     kinase; MAP kinase 10; MAP kinase p49 3F12; c-Jun
                     N-terminal kinase 3; stress-activated protein kinase JNK3;
                     SAPK/Erk/kinase 2"
                     /calculated_mol_wt=43966
     Region          25..360
                     /region_name="STKc_JNK"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     c-Jun N-terminal Kinase; cd07850"
                     /db_xref="CDD:270840"
     Site            order(32..38,40,53,55,72,86,108..114,116..117,151,153,
                     155..156,158,168..169,172,183,185..188,190,227)
                     /site_type="active"
                     /db_xref="CDD:270840"
     Site            order(32..38,40,53,55,86,108..114,158,168)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270840"
     Site            order(72,116,151,153,172,183,185..188,190,227)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270840"
     Site            order(112,118,127,130,159..163,323..324,326,329)
                     /site_type="other"
                     /note="KIM docking site [polypeptide binding]"
                     /db_xref="CDD:270840"
     Site            order(168..178,182..190)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270840"
     CDS             1..384
                     /gene="Mapk10"
                     /gene_synonym="C230008H04Rik; JNK3; JNK3B1; JNK3B2;
                     p493F12; p54bSAPK; SAPK(beta); Serk2"
                     /coded_by="NM_001407592.1:951..2105"
                     /note="isoform 5 is encoded by transcript variant 20"
                     /db_xref="GeneID:26414"
                     /db_xref="MGI:MGI:1346863"
ORIGIN      
        1 mskskvdnqf ysvevgdstf tvlkryqnlk pigsgaqgiv caaydavldr nvaikklsrp
       61 fqnqthakra yrelvlmkcv nhkniislln vftpqktlee fqdvylvmel mdanlcqviq
      121 meldhermsy llyqmlcgik hlhsagiihr dlkpsnivvk sdctlkildf glartagtsf
      181 mmtpyvvtry yrapevilgm gykenvdiws vgcimgemvr hkilfpgrdy idqwnkvieq
      241 lgtpcpefmk klqptvrnyv enrpkyaglt fpklfpdslf padsehnklk asqardllsk
      301 mlvidpakri svddalqhpy invwydpaev eapppqiydk qlderehtie ewkeliykev
      361 mnseektkng vvkgqpspsa qvqq
//
LOCUS       NP_033184                422 aa            linear   ROD 09-OCT-2023
DEFINITION  mitogen-activated protein kinase 10 isoform 2 [Mus musculus].
ACCESSION   NP_033184 NP_795944
VERSION     NP_033184.2
DBSOURCE    REFSEQ: accession NM_009158.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 422)
  AUTHORS   Priego M, Noriega L, Kalinin S, Hoffman LM, Feinstein DL and
            Morfini G.
  TITLE     Genetic deletion of c-Jun amino-terminal kinase 3 (JNK3) modestly
            increases disease severity in a mouse model of multiple sclerosis
  JOURNAL   J Neuroimmunol 382, 578152 (2023)
   PUBMED   37454525
  REMARK    GeneRIF: Genetic deletion of c-Jun amino-terminal kinase 3 (JNK3)
            modestly increases disease severity in a mouse model of multiple
            sclerosis.
REFERENCE   2  (residues 1 to 422)
  AUTHORS   Liu F, Deng Y, Zhao Y, Li Z, Gao J, Zhang Y, Yang X, Liu Y and Xia
            Y.
  TITLE     Time series RNA-seq analysis identifies MAPK10 as a critical gene
            in diabetes mellitus-induced atrial fibrillation in mice
  JOURNAL   J Mol Cell Cardiol 168, 70-82 (2022)
   PUBMED   35489387
  REMARK    GeneRIF: Time series RNA-seq analysis identifies MAPK10 as a
            critical gene in diabetes mellitus-induced atrial fibrillation in
            mice.
REFERENCE   3  (residues 1 to 422)
  AUTHORS   Cunningham JG, Scripter JD, Nti SA and Tucker ES.
  TITLE     Early construction of the thalamocortical axon pathway requires
            c-Jun N-terminal kinase signaling within the ventral forebrain
  JOURNAL   Dev Dyn 251 (3), 459-480 (2022)
   PUBMED   34494344
REFERENCE   4  (residues 1 to 422)
  AUTHORS   Goodwani S, Fernandez C, Acton PJ, Buggia-Prevot V, McReynolds ML,
            Ma J, Hu CH, Hamby ME, Jiang Y, Le K, Soth MJ, Jones P and Ray WJ.
  TITLE     Dual Leucine Zipper Kinase Is Constitutively Active in the Adult
            Mouse Brain and Has Both Stress-Induced and Homeostatic Functions
  JOURNAL   Int J Mol Sci 21 (14), 4849 (2020)
   PUBMED   32659913
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 422)
  AUTHORS   Loughran G, Chou MY, Ivanov IP, Jungreis I, Kellis M, Kiran AM,
            Baranov PV and Atkins JF.
  TITLE     Evidence of efficient stop codon readthrough in four mammalian
            genes
  JOURNAL   Nucleic Acids Res 42 (14), 8928-8938 (2014)
   PUBMED   25013167
REFERENCE   6  (residues 1 to 422)
  AUTHORS   Beier H and Grimm M.
  TITLE     Misreading of termination codons in eukaryotes by natural nonsense
            suppressor tRNAs
  JOURNAL   Nucleic Acids Res 29 (23), 4767-4782 (2001)
   PUBMED   11726686
  REMARK    Review article
REFERENCE   7  (residues 1 to 422)
  AUTHORS   Yang DD, Kuan CY, Whitmarsh AJ, Rincon M, Zheng TS, Davis RJ, Rakic
            P and Flavell RA.
  TITLE     Absence of excitotoxicity-induced apoptosis in the hippocampus of
            mice lacking the Jnk3 gene
  JOURNAL   Nature 389 (6653), 865-870 (1997)
   PUBMED   9349820
REFERENCE   8  (residues 1 to 422)
  AUTHORS   Casanova E, Garate C, Ovalle S, Calvo P and Chinchetru MA.
  TITLE     Identification of four splice variants of the mouse
            stress-activated protein kinase JNK/SAPK alpha-isoform
  JOURNAL   Neuroreport 7 (7), 1320-1324 (1996)
   PUBMED   8817558
REFERENCE   9  (residues 1 to 422)
  AUTHORS   Martin JH, Mohit AA and Miller CA.
  TITLE     Developmental expression in the mouse nervous system of the p493F12
            SAP kinase
  JOURNAL   Brain Res Mol Brain Res 35 (1-2), 47-57 (1996)
   PUBMED   8717339
REFERENCE   10 (residues 1 to 422)
  AUTHORS   Suzuki J, Yoshida S, Chen ZL, Momota Y, Kato K, Hirata A and
            Shiosaka S.
  TITLE     Ontogeny of neuropsin mRNA expression in the mouse brain
  JOURNAL   Neurosci Res 23 (4), 345-351 (1995)
   PUBMED   8602273
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC160244.11, AC123664.15,
            AC137121.9 and AC125252.7.
            
            On or before Feb 16, 2007 this sequence version replaced
            NP_795944.1, NP_033184.1.
            
            Summary: The protein encoded by this gene is a member of the MAP
            kinase family. MAP kinases act as integration points for multiple
            biochemical signals, and thus are involved in a wide variety of
            cellular processes, such as proliferation, differentiation,
            transcription regulation and development. This kinase is
            specifically expressed in a subset of neurons in the nervous system
            and is activated by threonine and tyrosine phosphorylation.
            Targeted deletion of this gene in mice suggests that it may have a
            role in stress-induced neuronal apoptosis. Alternatively spliced
            transcript variants encoding different isoforms have been found for
            this gene. A recent study provided evidence for translational
            readthrough in this gene, and expression of an additional
            C-terminally extended isoform via the use of an alternative
            in-frame translation termination codon. [provided by RefSeq, Dec
            2017].
            
            Transcript Variant: This variant (2) uses an alternate acceptor
            splice site at the 3' terminal exon, which causes a frameshift
            compared to variant 1. The resulting isoform (2, also know as JNK3
            alpha1) has a shorter and distinct C-terminus compared to isoform
            1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.247712.1,
                                           SRR1660825.63614.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..422
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 49.61 cM"
     Protein         1..422
                     /product="mitogen-activated protein kinase 10 isoform 2"
                     /EC_number="2.7.11.24"
                     /note="JNK3 beta1 protein kinase; JNK3 beta2 protein
                     kinase; MAP kinase 10; MAP kinase p49 3F12; c-Jun
                     N-terminal kinase 3; stress-activated protein kinase JNK3;
                     SAPK/Erk/kinase 2"
                     /calculated_mol_wt=48356
     Region          63..398
                     /region_name="STKc_JNK"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     c-Jun N-terminal Kinase; cd07850"
                     /db_xref="CDD:270840"
     Site            order(70..76,78,91,93,110,124,146..152,154..155,189,191,
                     193..194,196,206..207,210,221,223..226,228,265)
                     /site_type="active"
                     /db_xref="CDD:270840"
     Site            order(70..76,78,91,93,124,146..152,196,206)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270840"
     Site            order(110,154,189,191,210,221,223..226,228,265)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270840"
     Site            order(150,156,165,168,197..201,361..362,364,367)
                     /site_type="other"
                     /note="KIM docking site [polypeptide binding]"
                     /db_xref="CDD:270840"
     Site            order(206..216,220..228)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270840"
     Region          221..223
                     /region_name="TXY"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61831.2)"
     Site            221
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by MAP2K7.
                     /evidence=ECO:0000250|UniProtKB:P53779; propagated from
                     UniProtKB/Swiss-Prot (Q61831.2)"
     Site            223
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by MAP2K4.
                     /evidence=ECO:0000250|UniProtKB:P53779; propagated from
                     UniProtKB/Swiss-Prot (Q61831.2)"
     CDS             1..422
                     /gene="Mapk10"
                     /gene_synonym="C230008H04Rik; JNK3; JNK3B1; JNK3B2;
                     p493F12; p54bSAPK; SAPK(beta); Serk2"
                     /coded_by="NM_009158.4:517..1785"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="GeneID:26414"
                     /db_xref="MGI:MGI:1346863"
ORIGIN      
        1 mslhflyycs eptldvkiaf cqgfdkhvdv ssiakhynms kskvdnqfys vevgdstftv
       61 lkryqnlkpi gsgaqgivca aydavldrnv aikklsrpfq nqthakrayr elvlmkcvnh
      121 kniisllnvf tpqktleefq dvylvmelmd anlcqviqme ldhermsyll yqmlcgikhl
      181 hsagiihrdl kpsnivvksd ctlkildfgl artagtsfmm tpyvvtryyr apevilgmgy
      241 kenvdiwsvg cimgemvrhk ilfpgrdyid qwnkvieqlg tpcpefmkkl qptvrnyven
      301 rpkyagltfp klfpdslfpa dsehnklkas qardllskml vidpakrisv ddalqhpyin
      361 vwydpaevea pppqiydkql derehtieew keliykevmn seektkngvv kgqpspsaqv
      421 qq
//
LOCUS       NP_080535                317 aa            linear   ROD 09-OCT-2023
DEFINITION  E3 ubiquitin-protein ligase NRDP1 [Mus musculus].
ACCESSION   NP_080535
VERSION     NP_080535.2
DBSOURCE    REFSEQ: accession NM_026259.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 317)
  AUTHORS   Luo ZY, Jiang TX, Zhang T, Xu P and Qiu XB.
  TITLE     Ubiquitin Ligase Nrdp1 Controls Autophagy-Associated Acrosome
            Biogenesis and Mitochondrial Arrangement during Spermiogenesis
  JOURNAL   Cells 12 (18), 2211 (2023)
   PUBMED   37759433
  REMARK    GeneRIF: Ubiquitin Ligase Nrdp1 Controls Autophagy-Associated
            Acrosome Biogenesis and Mitochondrial Arrangement during
            Spermiogenesis.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 317)
  AUTHORS   Moreno-Lanceta A, Medrano-Bosch M, Fundora Y, Perramon M, Aspas J,
            Parra-Robert M, Baena S, Fondevila C, Edelman ER, Jimenez W and
            Melgar-Lesmes P.
  TITLE     RNF41 orchestrates macrophage-driven fibrosis resolution and
            hepatic regeneration
  JOURNAL   Sci Transl Med 15 (704), eabq6225 (2023)
   PUBMED   37437019
  REMARK    GeneRIF: RNF41 orchestrates macrophage-driven fibrosis resolution
            and hepatic regeneration.
REFERENCE   3  (residues 1 to 317)
  AUTHORS   Meng Z, Xu R, Xie L, Wu Y, He Q, Gao P, He X, Chen Q, Xie Q, Zhang
            J and Yang Q.
  TITLE     A20/Nrdp1 interaction alters the inflammatory signaling profile by
            mediating K48- and K63-linked polyubiquitination of effectors MyD88
            and TBK1
  JOURNAL   J Biol Chem 297 (1), 100811 (2021)
   PUBMED   34023381
  REMARK    GeneRIF: A20/Nrdp1 interaction alters the inflammatory signaling
            profile by mediating K48- and K63-linked polyubiquitination of
            effectors MyD88 and TBK1.
REFERENCE   4  (residues 1 to 317)
  AUTHORS   Tullett KM, Tan PS, Park HY, Schittenhelm RB, Michael N, Li R,
            Policheni AN, Gruber E, Huang C, Fulcher AJ, Danne JC, Czabotar PE,
            Wakim LM, Mintern JD, Ramm G, Radford KJ, Caminschi I, O'Keeffe M,
            Villadangos JA, Wright MD, Blewitt ME, Heath WR, Shortman K,
            Purcell AW, Nicola NA, Zhang JG and Lahoud MH.
  TITLE     RNF41 regulates the damage recognition receptor Clec9A and antigen
            cross-presentation in mouse dendritic cells
  JOURNAL   Elife 9, e63452 (2020)
   PUBMED   33264090
  REMARK    GeneRIF: RNF41 regulates the damage recognition receptor Clec9A and
            antigen cross-presentation in mouse dendritic cells.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 317)
  AUTHORS   Yang M, Chen T, Li X, Yu Z, Tang S, Wang C, Gu Y, Liu Y, Xu S, Li
            W, Zhang X, Wang J and Cao X.
  TITLE     K33-linked polyubiquitination of Zap70 by Nrdp1 controls CD8(+) T
            cell activation
  JOURNAL   Nat Immunol 16 (12), 1253-1262 (2015)
   PUBMED   26390156
  REMARK    GeneRIF: Data suggest that ring finger protein 41 Nrdp1 terminates
            T cell antigen receptors (TCRs) signaling by inactivating Zap70
            kinase.
            Erratum:[Nat Immunol. 2020 Mar;21(3):355. PMID: 32034311]
REFERENCE   6  (residues 1 to 317)
  AUTHORS   Wu X, Yen L, Irwin L, Sweeney C and Carraway KL 3rd.
  TITLE     Stabilization of the E3 ubiquitin ligase Nrdp1 by the
            deubiquitinating enzyme USP8
  JOURNAL   Mol Cell Biol 24 (17), 7748-7757 (2004)
   PUBMED   15314180
REFERENCE   7  (residues 1 to 317)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (residues 1 to 317)
  AUTHORS   Qiu XB and Goldberg AL.
  TITLE     Nrdp1/FLRF is a ubiquitin ligase promoting ubiquitination and
            degradation of the epidermal growth factor receptor family member,
            ErbB3
  JOURNAL   Proc Natl Acad Sci U S A 99 (23), 14843-14848 (2002)
   PUBMED   12411582
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):17220.]
REFERENCE   9  (residues 1 to 317)
  AUTHORS   Ogino Y, Suzuki K, Haraguchi R, Satoh Y, Dolle P and Yamada G.
  TITLE     External genitalia formation: role of fibroblast growth factor,
            retinoic acid signaling, and distal urethral epithelium
  JOURNAL   Ann N Y Acad Sci 948, 13-31 (2001)
   PUBMED   11795391
REFERENCE   10 (residues 1 to 317)
  AUTHORS   Abdullah JM, Li X, Nachtman RG and Jurecic R.
  TITLE     FLRF, a novel evolutionarily conserved RING finger gene, is
            differentially expressed in mouse fetal and adult hematopoietic
            stem cells and progenitors
  JOURNAL   Blood Cells Mol Dis 27 (1), 320-333 (2001)
   PUBMED   11358394
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK045760.1 and BC049078.1.
            
            On Jun 9, 2003 this sequence version replaced NP_080535.1.
            
            Transcript Variant: This variant (2) lacks an internal segment in
            the 3' UTR, compared to variant 1. Variants 1 and 2 encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049078.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..317
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 76.55 cM"
     Protein         1..317
                     /product="E3 ubiquitin-protein ligase NRDP1"
                     /EC_number="2.3.2.27"
                     /note="RING-type E3 ubiquitin transferase NRDP1"
                     /calculated_mol_wt=35760
     Region          15..57
                     /region_name="mRING-HC-C3HC3D_Nrdp1"
                     /note="Modified RING finger, HC subclass (C3HC3D-type),
                     found in neuregulin receptor degradation protein-1 (Nrdp1)
                     and similar proteins; cd16634"
                     /db_xref="CDD:438296"
     Region          137..315
                     /region_name="USP8_interact"
                     /note="USP8 interacting; pfam08941"
                     /db_xref="CDD:430333"
     CDS             1..317
                     /gene="Rnf41"
                     /gene_synonym="2210404G21Rik; 4930511A05Rik;
                     4933415P08Rik; D10Ertd722e; FLRF; Nrdp1"
                     /coded_by="NM_026259.3:417..1370"
                     /db_xref="CCDS:CCDS24277.1"
                     /db_xref="GeneID:67588"
                     /db_xref="MGI:MGI:1914838"
ORIGIN      
        1 mgydvtrfqg dvdedlicpi csgvleepvq aphcehafcn acitqwfsqq qtcpvdrsvv
       61 tvahlrpvpr imrnmlsklq iacdnavfgc savvrldnlm shlsdcehnp krpvtceqgc
      121 glempkdelp nhncikhlrs vvqqqqsria elektsaehk hqlaeqkrdi qllkaymrai
      181 rsvnpnlqnl eetieyneil ewvnslqpar vtrwggmist pdavlqavik rslvesgcpa
      241 sivneliena herswpqgla tletrqmnrr yyenyvakri pgkqavvvma cenqhmgddm
      301 vqepglvmif ahgveei
//
LOCUS       NP_001397160             486 aa            linear   ROD 09-OCT-2023
DEFINITION  nuclear respiratory factor 1 isoform i [Mus musculus].
ACCESSION   NP_001397160
VERSION     NP_001397160.1
DBSOURCE    REFSEQ: accession NM_001410231.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 486)
  AUTHORS   Cheng C, Tian Y, Yang R, Guo W, Xiao K, Zhang F, Tian J, Deng Z,
            Yang W, Yang H and Zhou Z.
  TITLE     miR-5581 Contributes to Osteoarthritis by Targeting NRF1 to Disturb
            the Proliferation and Functions of Chondrocytes
  JOURNAL   Am J Pathol 193 (9), 1234-1247 (2023)
   PUBMED   37611970
  REMARK    GeneRIF: miR-5581 Contributes to Osteoarthritis by Targeting NRF1
            to Disturb the Proliferation and Functions of Chondrocytes.
REFERENCE   2  (residues 1 to 486)
  AUTHORS   Meng Z, Liang B, Wu Y, Liu C, Wang H, Du Y, Gan L, Gao E, Lau WB,
            Christopher TA, Lopez BL, Koch WJ, Ma X, Zhao F, Wang Y and Zhao J.
  TITLE     Hypoadiponectinemia-induced upregulation of microRNA449b
            downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury
            in diabetic mice
  JOURNAL   J Mol Cell Cardiol 182, 1-14 (2023)
   PUBMED   37437402
  REMARK    GeneRIF: Hypoadiponectinemia-induced upregulation of microRNA449b
            downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury
            in diabetic mice.
REFERENCE   3  (residues 1 to 486)
  AUTHORS   Zhao T, Zhang J, Lei H, Meng Y, Cheng H, Zhao Y, Geng G, Mu C, Chen
            L, Liu Q, Luo Q, Zhang C, Long Y, Su J, Wang Y, Li Z, Sun J, Chen
            G, Li Y, Liao X, Shang Y, Hu G, Chen Q and Zhu Y.
  TITLE     NRF1-mediated mitochondrial biogenesis antagonizes innate antiviral
            immunity
  JOURNAL   EMBO J 42 (16), e113258 (2023)
   PUBMED   37409632
  REMARK    GeneRIF: NRF1-mediated mitochondrial biogenesis antagonizes innate
            antiviral immunity.
REFERENCE   4  (residues 1 to 486)
  AUTHORS   Akl MG, Baccetto R, Stebbings BM, Li L and Widenmaier SB.
  TITLE     Euglycemia is affected by stress defense factor hepatocyte NRF1,
            but not NRF2
  JOURNAL   Biochem Biophys Res Commun 668, 96-103 (2023)
   PUBMED   37245295
  REMARK    GeneRIF: Euglycemia is affected by stress defense factor hepatocyte
            NRF1, but not NRF2.
REFERENCE   5  (residues 1 to 486)
  AUTHORS   Akl MG, Li L, Baccetto R, Phanse S, Zhang Q, Trites MJ, McDonald S,
            Aoki H, Babu M and Widenmaier SB.
  TITLE     Complementary gene regulation by NRF1 and NRF2 protects against
            hepatic cholesterol overload
  JOURNAL   Cell Rep 42 (4), 112399 (2023)
   PUBMED   37060561
  REMARK    GeneRIF: Complementary gene regulation by NRF1 and NRF2 protects
            against hepatic cholesterol overload.
            Erratum:[Cell Rep. 2023 Jul 25;42(7):112872. PMID: 37454293]
REFERENCE   6  (residues 1 to 486)
  AUTHORS   Carmona MC, Iglesias R, Obregon MJ, Darlington GJ, Villarroya F and
            Giralt M.
  TITLE     Mitochondrial biogenesis and thyroid status maturation in brown fat
            require CCAAT/enhancer-binding protein alpha
  JOURNAL   J Biol Chem 277 (24), 21489-21498 (2002)
   PUBMED   11940593
REFERENCE   7  (residues 1 to 486)
  AUTHORS   Huo L and Scarpulla RC.
  TITLE     Mitochondrial DNA instability and peri-implantation lethality
            associated with targeted disruption of nuclear respiratory factor 1
            in mice
  JOURNAL   Mol Cell Biol 21 (2), 644-654 (2001)
   PUBMED   11134350
REFERENCE   8  (residues 1 to 486)
  AUTHORS   Schaefer L, Engman H and Miller JB.
  TITLE     Coding sequence, chromosomal localization, and expression pattern
            of Nrf1: the mouse homolog of Drosophila erect wing
  JOURNAL   Mamm Genome 11 (2), 104-110 (2000)
   PUBMED   10656923
REFERENCE   9  (residues 1 to 486)
  AUTHORS   Huo L and Scarpulla RC.
  TITLE     Multiple 5'-untranslated exons in the nuclear respiratory factor 1
            gene span 47 kb and contribute to transcript heterogeneity and
            translational efficiency
  JOURNAL   Gene 233 (1-2), 213-224 (1999)
   PUBMED   10375638
REFERENCE   10 (residues 1 to 486)
  AUTHORS   Virbasius CA, Virbasius JV and Scarpulla RC.
  TITLE     NRF-1, an activator involved in nuclear-mitochondrial interactions,
            utilizes a new DNA-binding domain conserved in a family of
            developmental regulators
  JOURNAL   Genes Dev 7 (12A), 2431-2445 (1993)
   PUBMED   8253388
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134897.4 and AC153632.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422598.979493.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..486
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 12.47 cM"
     Protein         1..486
                     /product="nuclear respiratory factor 1 isoform i"
                     /note="NRF-1; alpha-pal; alpha palindromic-binding
                     protein"
                     /calculated_mol_wt=52037
     Region          87..295
                     /region_name="Nrf1_DNA-bind"
                     /note="NLS-binding and DNA-binding and dimerization
                     domains of Nrf1; pfam10491"
                     /db_xref="CDD:402218"
     CDS             1..486
                     /gene="Nrf1"
                     /gene_synonym="D6Ertd415e"
                     /coded_by="NM_001410231.1:271..1731"
                     /note="isoform i is encoded by transcript variant 21"
                     /db_xref="GeneID:18181"
                     /db_xref="MGI:MGI:1332235"
ORIGIN      
        1 meehgvtqte hmatieahav aqqvqqvhva tytehsmlsa dedspssped tsyddsdiln
       61 staadevtah laaavlgikp rashilgpvg maaaaavatg kkrkrphvfe snpsirkrqq
      121 trllrklrat ldeyttrvgq qaivlcisps kpnpvfkvfg aaplenvvrk yksmiledle
      181 salaehapap qevnselppl tidgipvsvd kmtqaqlraf ipemlkystg rgkpgwgkes
      241 ckpiwwpedi pwanvrsdvr teeqkqrvsw tqalrtivkn cykqhgredl lyafedqqtq
      301 tqattthsia hlvpsqtvvq tfsnpdgtvs liqvgtgatv atladaselp ttvtvaqvny
      361 savadgeveq nwatlqggem tiqttqasea tqavaslaea avaasqemqq gatvtmalns
      421 eaaahavatl aeatlqgggq ivlsgetaaa vgaltgvqda nglfmadcgg ykwilarrlq
      481 awsrsl
//
LOCUS       NP_001349251             484 aa            linear   ROD 09-OCT-2023
DEFINITION  CUGBP Elav-like family member 4 isoform 39 [Mus musculus].
ACCESSION   NP_001349251
VERSION     NP_001349251.1
DBSOURCE    REFSEQ: accession NM_001362322.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 484)
  AUTHORS   Salamon I, Park Y, Miskic T, Kopic J, Matteson P, Page NF, Roque A,
            McAuliffe GW, Favate J, Garcia-Forn M, Shah P, Judas M, Millonig
            JH, Kostovic I, De Rubeis S, Hart RP, Krsnik Z and Rasin MR.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    GeneRIF: Celf4 controls mRNA translation underlying synaptic
            development in the prenatal mammalian neocortex.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 484)
  AUTHORS   Shen Y, Zhang C, Xiao K, Liu D and Xie G.
  TITLE     CELF4 regulates spine formation and depression-like behaviors of
            mice
  JOURNAL   Biochem Biophys Res Commun 605, 39-44 (2022)
   PUBMED   35306363
  REMARK    GeneRIF: CELF4 regulates spine formation and depression-like
            behaviors of mice.
REFERENCE   3  (residues 1 to 484)
  AUTHORS   Moreau MX, Saillour Y, Cwetsch AW, Pierani A and Causeret F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   4  (residues 1 to 484)
  AUTHORS   Li C, Li X, Bi Z, Sugino K, Wang G, Zhu T and Liu Z.
  TITLE     Comprehensive transcriptome analysis of cochlear spiral ganglion
            neurons at multiple ages
  JOURNAL   Elife 9, e50491 (2020)
   PUBMED   31913118
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 484)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 484)
  AUTHORS   Ladd AN, Taffet G, Hartley C, Kearney DL and Cooper TA.
  TITLE     Cardiac tissue-specific repression of CELF activity disrupts
            alternative splicing and causes cardiomyopathy
  JOURNAL   Mol Cell Biol 25 (14), 6267-6278 (2005)
   PUBMED   15988035
  REMARK    GeneRIF: CELF protein activity is required for normal alternative
            splicing in the heart in vivo and normal CELF-mediated alternative
            splicing regulation is in turn required for normal cardiac
            function.
REFERENCE   7  (residues 1 to 484)
  AUTHORS   Meins M, Schlickum S, Wilhelm C, Missbach J, Yadav S, Glaser B,
            Grzmil M, Burfeind P and Laccone F.
  TITLE     Identification and characterization of murine Brunol4, a new member
            of the elav/bruno family
  JOURNAL   Cytogenet Genome Res 97 (3-4), 254-260 (2002)
   PUBMED   12438720
  REMARK    GeneRIF: cloning and characterization
REFERENCE   8  (residues 1 to 484)
  AUTHORS   Ladd AN, Charlet N and Cooper TA.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   9  (residues 1 to 484)
  AUTHORS   Good PJ, Chen Q, Warner SJ and Herring DC.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
REFERENCE   10 (residues 1 to 484)
  AUTHORS   Yulug IG, Egan SE, See CG and Fisher EM.
  TITLE     Mapping GRB2, a signal transduction gene in the human and the mouse
  JOURNAL   Genomics 22 (2), 313-318 (1994)
   PUBMED   7806216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121094.8 and AC144938.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.27355.1,
                                           SRR1660815.54324.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..484
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 13.92 cM"
     Protein         1..484
                     /product="CUGBP Elav-like family member 4 isoform 39"
                     /note="CUG-BP- and ETR-3-like factor 4; bruno-like protein
                     4; RNA-binding protein BRUNOL-4; bruno-like 4, RNA binding
                     protein"
                     /calculated_mol_wt=51617
     Region          18..39
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          49..135
                     /region_name="RRM1_CELF3_4_5_6"
                     /note="RNA recognition motif 1 (RRM1) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12632"
                     /db_xref="CDD:410041"
     Site            order(55,57,59..60,63,82,84,86,95..97,99,129,131)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410041"
     Region          121..149
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          151..231
                     /region_name="RRM2_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12635"
                     /db_xref="CDD:410043"
     Site            order(153,155,157..158,161,180,182,184,192..194,196,226,
                     228)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410043"
     Region          239..258
                     /region_name="Necessary for TNNT2 exon 5 inclusion.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          415..473
                     /region_name="RRM_SF"
                     /note="RNA recognition motif (RRM) superfamily; cl17169"
                     /db_xref="CDD:450164"
     CDS             1..484
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /coded_by="NM_001362322.1:531..1985"
                     /note="isoform 39 is encoded by transcript variant 42"
                     /db_xref="GeneID:108013"
                     /db_xref="MGI:MGI:1932407"
ORIGIN      
        1 myikmatlan gqadnaslst nglgsspgsa ghmnglshsp gnpstipmkd hdaiklfigq
       61 iprnldekdl kplfeefgki yeltvlkdrf tgmhkgcafl tyceresalk aqsalheqkt
      121 lpgmnrpiqv kpadsesrgg ssclrqppsq drklfvgmln kqqseddvrr lfeafgniee
      181 ctilrgpdgn skgcafvkys shaeaqaain alhgsqtmpg assslvvkfa dtdkertmrr
      241 mqqmagqmgm fnpmaipfga ygayaqamqq qaalmasvaq ggylnpmaaf aaaqmqqmaa
      301 lnmnglaaap mtptsggstp pgitapavps ipspigvngf tglppqangq paaeavfang
      361 ihpypaqspt aadplqqaya gvqqyagpay paaygqisqa fpqpppmipq qqregpegcn
      421 lliyhlpqef gdaelmqmfl pfgfvsfdnp asaqtaiqam ngfqigmkrl kvqlkrpkda
      481 nrpy
//
LOCUS       NP_001240683             267 aa            linear   ROD 09-OCT-2023
DEFINITION  neuronal membrane glycoprotein M6-a isoform 2 [Mus musculus].
ACCESSION   NP_001240683
VERSION     NP_001240683.1
DBSOURCE    REFSEQ: accession NM_001253754.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 267)
  AUTHORS   Li L, Sun Y, Davis AE, Shah SH, Hamed LK, Wu MR, Lin CH, Ding JB
            and Wang S.
  TITLE     Mettl14-mediated m6A modification ensures the cell-cycle
            progression of late-born retinal progenitor cells
  JOURNAL   Cell Rep 42 (6), 112596 (2023)
   PUBMED   37269288
  REMARK    GeneRIF: Mettl14-mediated m[6]A modification ensures the cell-cycle
            progression of late-born retinal progenitor cells.
REFERENCE   2  (residues 1 to 267)
  AUTHORS   Xie W, Zhang A, Huang X, Zhou H, Ying H, Ye C, Ren M, Qian M, Liu X
            and Mo Y.
  TITLE     SILENCING M 6 A READER YTHDC1 REDUCES INFLAMMATORY RESPONSE IN
            SEPSIS-INDUCED CARDIOMYOPATHY BY INHIBITING SERPINA3N EXPRESSION
  JOURNAL   Shock 59 (5), 791-802 (2023)
   PUBMED   36877222
  REMARK    GeneRIF: SILENCING M 6 A READER YTHDC1 REDUCES INFLAMMATORY
            RESPONSE IN SEPSIS-INDUCED CARDIOMYOPATHY BY INHIBITING SERPINA3N
            EXPRESSION.
REFERENCE   3  (residues 1 to 267)
  AUTHORS   Xue A, Huang Y, Li M, Wei Q and Bu Q.
  TITLE     Comprehensive Analysis of Differential m6A RNA Methylomes in the
            Hippocampus of Cocaine-Conditioned Mice
  JOURNAL   Mol Neurobiol 58 (8), 3759-3768 (2021)
   PUBMED   33826069
  REMARK    GeneRIF: Comprehensive Analysis of Differential m6A RNA Methylomes
            in the Hippocampus of Cocaine-Conditioned Mice.
REFERENCE   4  (residues 1 to 267)
  AUTHORS   Bedogni F and Hevner RF.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 267)
  AUTHORS   Ogawa T, Li Y, Lua I, Hartner A and Asahina K.
  TITLE     Isolation of a unique hepatic stellate cell population expressing
            integrin alpha8 from embryonic mouse livers
  JOURNAL   Dev Dyn 247 (6), 867-881 (2018)
   PUBMED   29665133
REFERENCE   6  (residues 1 to 267)
  AUTHORS   Yan Y, Narayanan V and Lagenaur C.
  TITLE     Expression of members of the proteolipid protein gene family in the
            developing murine central nervous system
  JOURNAL   J Comp Neurol 370 (4), 465-478 (1996)
   PUBMED   8807448
REFERENCE   7  (residues 1 to 267)
  AUTHORS   Olinsky S, Loop BT, DeKosky A, Ripepi B, Weng W, Cummins J, Wenger
            SL, Yan Y, Lagenaur C and Narayanan V.
  TITLE     Chromosomal mapping of the human M6 genes
  JOURNAL   Genomics 33 (3), 532-536 (1996)
   PUBMED   8661015
REFERENCE   8  (residues 1 to 267)
  AUTHORS   Shimizu F, Watanabe TK, Fujiwara T, Takahashi E, Nakamura Y and
            Maekawa H.
  TITLE     Isolation and mapping of the human glycoprotein M6 gene (GPM6A) to
            4q33-->q34
  JOURNAL   Cytogenet Cell Genet 74 (1-2), 138-139 (1996)
   PUBMED   8893821
REFERENCE   9  (residues 1 to 267)
  AUTHORS   Yan Y, Lagenaur C and Narayanan V.
  TITLE     Molecular cloning of M6: identification of a PLP/DM20 gene family
  JOURNAL   Neuron 11 (3), 423-431 (1993)
   PUBMED   8398137
REFERENCE   10 (residues 1 to 267)
  AUTHORS   Baumrind NL, Parkinson D, Wayne DB, Heuser JE and Pearlman AL.
  TITLE     EMA: a developmentally regulated cell-surface glycoprotein of CNS
            neurons that is concentrated at the leading edge of growth cones
  JOURNAL   Dev Dyn 194 (4), 311-325 (1992)
   PUBMED   1286213
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC109200.13, CK623810.1, CX564488.1 and BC033357.1.
            
            Transcript Variant: This variant (2) has a different segment for
            its 5' end which results in the use of an alternate start codon,
            compared to variant 1. The encoded protein (isoform 2) has a
            distinct N-terminus and is shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660821.130598.1,
                                           SRR1660811.210792.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..267
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 29.33 cM"
     Protein         1..267
                     /product="neuronal membrane glycoprotein M6-a isoform 2"
                     /note="neuronal membrane glycoprotein M6-a"
                     /calculated_mol_wt=29714
     Region          4..236
                     /region_name="Myelin_PLP"
                     /note="Myelin proteolipid protein (PLP or lipophilin);
                     pfam01275"
                     /db_xref="CDD:426173"
     CDS             1..267
                     /gene="Gpm6a"
                     /gene_synonym="Gpm6; M6A"
                     /coded_by="NM_001253754.1:214..1017"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="GeneID:234267"
                     /db_xref="MGI:MGI:107671"
ORIGIN      
        1 mgcfeccikc lggipyasli atillyagva lfcgcgheal sgtvnilqty felartagdt
       61 ldvftmidif kyviygiaaa ffvygillmv egffttgaik dlygdfkitt cgrcvsawfi
      121 mltylfmlaw lgvtaftslp vymyfnvwti crnttlvega nlcldlrqfg ivtigeekki
      181 ctasenflrm cestelnmtf hlfivalaga gaaviamvhy lmvlsanway vkdacrmqky
      241 edikskeeqe lhdihstrsk erlnayt
//
LOCUS       NP_001300983             165 aa            linear   ROD 09-OCT-2023
DEFINITION  interleukin-6 isoform 2 precursor [Mus musculus].
ACCESSION   NP_001300983
VERSION     NP_001300983.1
DBSOURCE    REFSEQ: accession NM_001314054.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 165)
  AUTHORS   Palmisano B, Riminucci M and Karsenty G.
  TITLE     Interleukin-6 signaling in osteoblasts regulates bone remodeling
            during exercise
  JOURNAL   Bone 176, 116870 (2023)
   PUBMED   37586472
  REMARK    GeneRIF: Interleukin-6 signaling in osteoblasts regulates bone
            remodeling during exercise.
REFERENCE   2  (residues 1 to 165)
  AUTHORS   Zhu Y, Wang L, Liu R, Ding X, Yin S, Chen Y, Zhu C, Wang Z and Li
            W.
  TITLE     Inhibition of PRMT1 alleviates sepsis-induced acute kidney injury
            in mice by blocking the TGF-beta1 and IL-6 trans-signaling pathways
  JOURNAL   FEBS Open Bio 13 (10), 1859-1873 (2023)
   PUBMED   37525933
  REMARK    GeneRIF: Inhibition of PRMT1 alleviates sepsis-induced acute kidney
            injury in mice by blocking the TGF-beta1 and IL-6 trans-signaling
            pathways.
REFERENCE   3  (residues 1 to 165)
  AUTHORS   Okamura K, Lu S, He Z, Altmann C, Montford JR, Li AS, Lucia MS,
            Orlicky DJ, Weiser-Evans M and Faubel S.
  TITLE     IL-6 mediates the hepatic acute phase response after prerenal
            azotemia in a clinically defined murine model
  JOURNAL   Am J Physiol Renal Physiol 325 (3), F328-F344 (2023)
   PUBMED   37471421
  REMARK    GeneRIF: IL-6 mediates the hepatic acute phase response after
            prerenal azotemia in a clinically defined murine model.
REFERENCE   4  (residues 1 to 165)
  AUTHORS   Millrine D, Cardus Figueras A, Uceda Fernandez J, Andrews R,
            Szomolay B, Cossins BC, Rice CM, Li J, Tyrrell VJ, McLeod L,
            Holmans P, O'Donnell VB, Taylor PR, Turner SJ, Jenkins BJ, Jones
            GW, Topley N, Williams NM and Jones SA.
  TITLE     Th1 Cells Alter the Inflammatory Signature of IL-6 by Channeling
            STAT Transcription Factors to Alu-like Retroelements
  JOURNAL   J Immunol 211 (2), 274-286 (2023)
   PUBMED   37272871
  REMARK    GeneRIF: Th1 Cells Alter the Inflammatory Signature of IL-6 by
            Channeling STAT Transcription Factors to Alu-like Retroelements.
REFERENCE   5  (residues 1 to 165)
  AUTHORS   Choi BR, Johnson KR, Maric D and McGavern DB.
  TITLE     Monocyte-derived IL-6 programs microglia to rebuild damaged brain
            vasculature
  JOURNAL   Nat Immunol 24 (7), 1110-1123 (2023)
   PUBMED   37248420
  REMARK    GeneRIF: Monocyte-derived IL-6 programs microglia to rebuild
            damaged brain vasculature.
REFERENCE   6  (residues 1 to 165)
  AUTHORS   Chin H, Mock B, Kim HL, Kim H and Kozak CA.
  TITLE     The gene for the dihydropyridine-sensitive calcium channel alpha 2
            subunit (CCHL2A) maps to the proximal region of mouse chromosome 5
  JOURNAL   Genomics 13 (4), 1325-1327 (1992)
   PUBMED   1324224
REFERENCE   7  (residues 1 to 165)
  AUTHORS   Okada S, Nakauchi H, Nagayoshi K, Nakamura M, Miura Y and Suda T.
  TITLE     Synergistic effect of IL-3 and IL-6 on highly enriched murine
            hemopoietic progenitors
  JOURNAL   Exp Hematol 20 (5), 546-551 (1992)
   PUBMED   1350248
REFERENCE   8  (residues 1 to 165)
  AUTHORS   Vandevoorde V, Haegeman G and Fiers W.
  TITLE     TNF-mediated IL6 gene expression and cytotoxicity are co-inducible
            in TNF-resistant L929 cells
  JOURNAL   FEBS Lett 302 (3), 235-238 (1992)
   PUBMED   1318227
REFERENCE   9  (residues 1 to 165)
  AUTHORS   Fiorillo MT, Toniatti C, Van Snick J and Ciliberto G.
  TITLE     Expression of the murine interleukin 6 receptor in hepatoma cells:
            the intracytoplasmic domain is not required for interleukin 6
            signal transduction
  JOURNAL   Eur J Immunol 22 (3), 799-804 (1992)
   PUBMED   1312474
REFERENCE   10 (residues 1 to 165)
  AUTHORS   Bodine DM, Orlic D, Birkett NC, Seidel NE and Zsebo KM.
  TITLE     Stem cell factor increases colony-forming unit-spleen number in
            vitro in synergy with interleukin-6, and in vivo in Sl/Sld mice as
            a single factor
  JOURNAL   Blood 79 (4), 913-919 (1992)
   PUBMED   1371079
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC112933.16, BC145409.1 and
            AK150440.1.
            
            Summary: This gene encodes a member of the interleukin family of
            cytokines that have important functions in immune response,
            hematopoiesis, inflammation and the acute phase response. The
            ectopic overexpression of the encoded protein in mice results in
            excessive plasma cells in circulation, leading to death. Mice
            lacking the encoded protein exhibit abnormalities in hepatic acute
            phase response, some immune mechanisms, bone resorption in response
            to estrogen, liver regeneration and wound healing. Alternative
            splicing results in multiple transcript variants encoding different
            isoforms. [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the 3' terminal exon, compared to variant 1. The encoded protein
            (isoform 2) is shorter and has a distinct C-terminus, compared to
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC145409.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN04095721, SAMN04095722
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..165
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 15.7 cM"
     Protein         1..165
                     /product="interleukin-6 isoform 2 precursor"
                     /note="interleukin HP-1; B-cell hybridoma growth factor"
                     /calculated_mol_wt=16370
     sig_peptide     1..24
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=2667
     Region          27..>157
                     /region_name="IL6"
                     /note="Interleukin-6/G-CSF/MGF family; cl02473"
                     /db_xref="CDD:413331"
     CDS             1..165
                     /gene="Il6"
                     /gene_synonym="Il-6"
                     /coded_by="NM_001314054.1:79..576"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2"
                     /db_xref="CCDS:CCDS84856.1"
                     /db_xref="GeneID:16193"
                     /db_xref="MGI:MGI:96559"
ORIGIN      
        1 mkflsardfh pvaflglmlv tttafptsqv rrgdftedtt pnrpvyttsq vgglithvlw
       61 eivemrkelc ngnsdcmnnd dalaennlkl peiqrndgcy qtgynqeicl lkissglley
      121 hsyleymknn lkdnkkdkar vlqrdtetli hifnqeisws hrrsg
//
LOCUS       NP_001005421             379 aa            linear   ROD 09-OCT-2023
DEFINITION  junctional adhesion molecule-like precursor [Mus musculus].
ACCESSION   NP_001005421 XP_194453
VERSION     NP_001005421.3
DBSOURCE    REFSEQ: accession NM_001005421.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 379)
  AUTHORS   Mraz V, Lohmann RKD, Menzel M, Hawkes A, Vaher H, Funch AB, Jee MH,
            Gadsboll AO, Weber JF, Yeung K, Odum N, Woetmann A, McKay D,
            Witherden D, Geisler C and Bonefeld CM.
  TITLE     The junctional adhesion molecule-like protein (JAML) is important
            for the inflammatory response during contact hypersensitivity
  JOURNAL   Contact Dermatitis 89 (5), 323-334 (2023)
   PUBMED   37619972
  REMARK    GeneRIF: The junctional adhesion molecule-like protein (JAML) is
            important for the inflammatory response during contact
            hypersensitivity.
REFERENCE   2  (residues 1 to 379)
  AUTHORS   Huang W, Wang BO, Hou YF, Fu Y, Cui SJ, Zhu JH, Zhan XY, Li RK,
            Tang W, Wu JC, Wang ZY, Wang M, Wang XJ, Zhang Y, Liu M, Xie YS,
            Sun Y and Yi F.
  TITLE     JAML promotes acute kidney injury mainly through a
            macrophage-dependent mechanism
  JOURNAL   JCI Insight 7 (14), e158571 (2022)
   PUBMED   35708906
  REMARK    GeneRIF: JAML promotes acute kidney injury mainly through a
            macrophage-dependent mechanism.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 379)
  AUTHORS   McGraw JM, Thelen F, Hampton EN, Bruno NE, Young TS, Havran WL and
            Witherden DA.
  TITLE     JAML promotes CD8 and gammadelta T cell antitumor immunity and is a
            novel target for cancer immunotherapy
  JOURNAL   J Exp Med 218 (10) (2021)
   PUBMED   34427588
  REMARK    GeneRIF: JAML promotes CD8 and gammadelta T cell antitumor immunity
            and is a novel target for cancer immunotherapy.
REFERENCE   4  (residues 1 to 379)
  AUTHORS   Fu Y, Sun Y, Wang M, Hou Y, Huang W, Zhou D, Wang Z, Yang S, Tang
            W, Zhen J, Li Y, Wang X, Liu M, Zhang Y, Wang B, Liu G, Yu X, Sun
            J, Zhang C and Yi F.
  TITLE     Elevation of JAML Promotes Diabetic Kidney Disease by Modulating
            Podocyte Lipid Metabolism
  JOURNAL   Cell Metab 32 (6), 1052-1062 (2020)
   PUBMED   33186558
  REMARK    GeneRIF: Elevation of JAML Promotes Diabetic Kidney Disease by
            Modulating Podocyte Lipid Metabolism.
REFERENCE   5  (residues 1 to 379)
  AUTHORS   Sun Y, Guan J, Hou Y, Xue F, Huang W, Zhang W, Zhang Y, Zhang C and
            Yang J.
  TITLE     Silencing of junctional adhesion molecule-like protein attenuates
            atherogenesis and enhances plaque stability in ApoE-/- mice
  JOURNAL   Clin Sci (Lond) 133 (11), 1215-1228 (2019)
   PUBMED   31101724
  REMARK    GeneRIF: silencing attenuates atherogenesis and enhances plaque
            stability in ApoE(-/-) mice
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 379)
  AUTHORS   Verdino P, Witherden DA, Ferguson MS, Corper AL, Schiefner A,
            Havran WL and Wilson IA.
  TITLE     Molecular insights into gammadelta T cell costimulation by an
            anti-JAML antibody
  JOURNAL   Structure 19 (1), 80-89 (2011)
   PUBMED   21220118
  REMARK    GeneRIF: crystal structure of the JAML-HL4E10 Fab complex
REFERENCE   7  (residues 1 to 379)
  AUTHORS   Verdino P, Witherden DA, Havran WL and Wilson IA.
  TITLE     The molecular interaction of CAR and JAML recruits the central cell
            signal transducer PI3K
  JOURNAL   Science 329 (5996), 1210-1214 (2010)
   PUBMED   20813955
  REMARK    GeneRIF: crystal structure of junctional adhesion molecule-like
            protein (JAML) and coxsackie and adenovirus receptor; data show how
            CAR-mediated clustering of JAML recruits phosphoinositide 3-kinase
            to a JAML intracellular sequence motif
REFERENCE   8  (residues 1 to 379)
  AUTHORS   Witherden DA, Verdino P, Rieder SE, Garijo O, Mills RE, Teyton L,
            Fischer WH, Wilson IA and Havran WL.
  TITLE     The junctional adhesion molecule JAML is a costimulatory receptor
            for epithelial gammadelta T cell activation
  JOURNAL   Science 329 (5996), 1205-1210 (2010)
   PUBMED   20813954
  REMARK    GeneRIF: identified an epithelial gammadelta T cell costimulatory
            molecule, junctional adhesion molecule-like protein - JAML; binding
            of JAML to CAR provides costimulation leading to cell proliferation
            and cytokine and growth factor production
REFERENCE   9  (residues 1 to 379)
  AUTHORS   Tang T, Li L, Tang J, Li Y, Lin WY, Martin F, Grant D, Solloway M,
            Parker L, Ye W, Forrest W, Ghilardi N, Oravecz T, Platt KA, Rice
            DS, Hansen GM, Abuin A, Eberhart DE, Godowski P, Holt KH, Peterson
            A, Zambrowicz BP and de Sauvage FJ.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   10 (residues 1 to 379)
  AUTHORS   Mirza M, Petersen C, Nordqvist K and Sollerbrant K.
  TITLE     Coxsackievirus and adenovirus receptor is up-regulated in migratory
            germ cells during passage of the blood-testis barrier
  JOURNAL   Endocrinology 148 (11), 5459-5469 (2007)
   PUBMED   17690169
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122305.4, CJ139627.1, CJ141417.1, AA798428.1, AA120429.1,
            CJ231590.1 and BX520654.1.
            
            On Nov 15, 2007 this sequence version replaced NP_001005421.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY093688.1, ERR3363658.1144488.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..379
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 24.84 cM"
     Protein         1..379
                     /product="junctional adhesion molecule-like precursor"
                     /note="dendritic-cell specific protein Crea7; mCrea7;
                     dendritic cell-specific protein CREA7; adhesion molecule
                     AMICA; adhesion molecule, interacts with CXADR antigen 1"
                     /calculated_mol_wt=40385
     sig_peptide     1..20
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=2166
     Region          33..139
                     /region_name="V-set"
                     /note="Immunoglobulin V-set domain; pfam07686"
                     /db_xref="CDD:429596"
     Region          58..61
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Site            79
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:20813955; propagated from
                     UniProtKB/Swiss-Prot (Q80UL9.2)"
     Site            89
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:20813955; propagated from
                     UniProtKB/Swiss-Prot (Q80UL9.2)"
     Region          102..106
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          116..121
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Site            125
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:20813955; propagated from
                     UniProtKB/Swiss-Prot (Q80UL9.2)"
     Region          141..254
                     /region_name="V-set"
                     /note="Immunoglobulin V-set domain; pfam07686"
                     /db_xref="CDD:429596"
     Region          154..158
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          170..174
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          219..223
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          233..238
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Site            282..302
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q80UL9.2)"
     Site            355
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine. /evidence=ECO:0000305; propagated
                     from UniProtKB/Swiss-Prot (Q80UL9.2)"
     CDS             1..379
                     /gene="Jaml"
                     /gene_synonym="AMICA; Amica1; Crea7; Gm638"
                     /coded_by="NM_001005421.4:232..1371"
                     /db_xref="CCDS:CCDS23128.1"
                     /db_xref="GeneID:270152"
                     /db_xref="MGI:MGI:2685484"
ORIGIN      
        1 mlcllklivi pvilapvgyp qglpgltvss pqlrvhvges vlmgcvvqrt eekhvdrvdw
       61 lfskdkddas eyvlfyysnl svptgrfqnr shlvgdtfhn dgslllqdvq kadegiytce
      121 irlknesmvm kkpvelwvlp eepkdlrvrv gdttqmrcsi qsteekrvtk vnwmfssgsh
      181 teeetvlsyd snmrsgkfqs lgrfrnrvdl tgdisrndgs iklqtvkesd qgiytcsiyv
      241 gklesrktiv lhvvqdefqr tisptpptdk gqqgilngnq lviivgivca tflllpvlil
      301 ivkkakwnks svssmasvks lenkekinpe khiyssittw ettergisge segtymtmnp
      361 vwpsspkass lvrssvrsk
//
LOCUS       NP_001132991             187 aa            linear   ROD 09-OCT-2023
DEFINITION  Z-DNA-binding protein 1 isoform 2 [Mus musculus].
ACCESSION   NP_001132991
VERSION     NP_001132991.1
DBSOURCE    REFSEQ: accession NM_001139519.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 187)
  AUTHORS   Sharma BR, Karki R, Rajesh Y and Kanneganti TD.
  TITLE     Immune regulator IRF1 contributes to ZBP1-, AIM2-, RIPK1-, and
            NLRP12-PANoptosome activation and inflammatory cell death
            (PANoptosis)
  JOURNAL   J Biol Chem 299 (9), 105141 (2023)
   PUBMED   37557956
  REMARK    GeneRIF: Immune regulator IRF1 contributes to ZBP1-, AIM2-, RIPK1-,
            and NLRP12-PANoptosome activation and inflammatory cell death
            (PANoptosis).
REFERENCE   2  (residues 1 to 187)
  AUTHORS   Lei Y, VanPortfliet JJ, Chen YF, Bryant JD, Li Y, Fails D,
            Torres-Odio S, Ragan KB, Deng J, Mohan A, Wang B, Brahms ON, Yates
            SD, Spencer M, Tong CW, Bosenberg MW, West LC, Shadel GS, Shutt TE,
            Upton JW, Li P and West AP.
  TITLE     Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes
            cardiotoxicity
  JOURNAL   Cell 186 (14), 3013-3032 (2023)
   PUBMED   37352855
  REMARK    GeneRIF: Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS
            promotes cardiotoxicity.
REFERENCE   3  (residues 1 to 187)
  AUTHORS   Cheng P, Jian Q, Fu Z, Deng R and Ma Y.
  TITLE     Inhibition of DAI refrains dendritic cells from maturation and
            prolongs murine islet and skin allograft survival
  JOURNAL   Front Immunol 14, 1182851 (2023)
   PUBMED   37197662
  REMARK    GeneRIF: Inhibition of DAI refrains dendritic cells from maturation
            and prolongs murine islet and skin allograft survival.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 187)
  AUTHORS   Enzan N, Matsushima S, Ikeda S, Okabe K, Ishikita A, Yamamoto T,
            Sada M, Miyake R, Tsutsui Y, Nishimura R, Toyohara T, Ikeda Y,
            Shojima Y, Miyamoto HD, Tadokoro T, Ikeda M, Abe K, Ide T, Kinugawa
            S and Tsutsui H.
  TITLE     ZBP1 Protects Against mtDNA-Induced Myocardial Inflammation in
            Failing Hearts
  JOURNAL   Circ Res 132 (9), 1110-1126 (2023)
   PUBMED   36974722
  REMARK    GeneRIF: ZBP1 Protects Against mtDNA-Induced Myocardial
            Inflammation in Failing Hearts.
REFERENCE   5  (residues 1 to 187)
  AUTHORS   Li S, Zhang Y, Guan Z, Ye M, Li H, You M, Zhou Z, Zhang C, Zhang F,
            Lu B, Zhou P and Peng K.
  TITLE     SARS-CoV-2 Z-RNA activates the ZBP1-RIPK3 pathway to promote
            virus-induced inflammatory responses
  JOURNAL   Cell Res 33 (3), 201-214 (2023)
   PUBMED   36650286
  REMARK    GeneRIF: SARS-CoV-2 Z-RNA activates the ZBP1-RIPK3 pathway to
            promote virus-induced inflammatory responses.
REFERENCE   6  (residues 1 to 187)
  AUTHORS   Wang Z, Choi MK, Ban T, Yanai H, Negishi H, Lu Y, Tamura T, Takaoka
            A, Nishikura K and Taniguchi T.
  TITLE     Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other
            DNA-sensing molecules
  JOURNAL   Proc Natl Acad Sci U S A 105 (14), 5477-5482 (2008)
   PUBMED   18375758
  REMARK    GeneRIF: mechanism of DAI activation and the complex regulatory
            mechanisms underlying DNA-mediated protective and pathologic immune
            responses.
REFERENCE   7  (residues 1 to 187)
  AUTHORS   Ishii KJ, Kawagoe T, Koyama S, Matsui K, Kumar H, Kawai T, Uematsu
            S, Takeuchi O, Takeshita F, Coban C and Akira S.
  TITLE     TANK-binding kinase-1 delineates innate and adaptive immune
            responses to DNA vaccines
  JOURNAL   Nature 451 (7179), 725-729 (2008)
   PUBMED   18256672
REFERENCE   8  (residues 1 to 187)
  AUTHORS   Takaoka A, Wang Z, Choi MK, Yanai H, Negishi H, Ban T, Lu Y,
            Miyagishi M, Kodama T, Honda K, Ohba Y and Taniguchi T.
  TITLE     DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of
            innate immune response
  JOURNAL   Nature 448 (7152), 501-505 (2007)
   PUBMED   17618271
  REMARK    GeneRIF: observations underscore an integral role of DAI
            (DLM-1/ZBP1) in the DNA-mediated activation of innate immune
            responses
REFERENCE   9  (residues 1 to 187)
  AUTHORS   Schwartz T, Behlke J, Lowenhaupt K, Heinemann U and Rich A.
  TITLE     Structure of the DLM-1-Z-DNA complex reveals a conserved family of
            Z-DNA-binding proteins
  JOURNAL   Nat Struct Biol 8 (9), 761-765 (2001)
   PUBMED   11524677
  REMARK    GeneRIF: shares common structure-specific recognition core within
            the binding domain with an RNA editing enzyme but binds Z-DNA
REFERENCE   10 (residues 1 to 187)
  AUTHORS   Fu Y, Comella N, Tognazzi K, Brown LF, Dvorak HF and Kocher O.
  TITLE     Cloning of DLM-1, a novel gene that is up-regulated in activated
            macrophages, using RNA differential display
  JOURNAL   Gene 240 (1), 157-163 (1999)
   PUBMED   10564822
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY170802.1 and AK008179.1.
            
            Transcript Variant: This variant (2) differs in the 3' UTR and has
            multiple differences in the 3' coding region, compared to variant
            1. The resulting isoform (2) has a shorter and distinct C-terminus,
            compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK008179.1, BI685388.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..187
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 95.83 cM"
     Protein         1..187
                     /product="Z-DNA-binding protein 1 isoform 2"
                     /note="tumor stroma and activated macrophage protein
                     DLM-1; DNA-dependent activator of IFN-regulatory factors"
                     /calculated_mol_wt=20437
     Region          8..72
                     /region_name="z-alpha"
                     /note="Adenosine deaminase z-alpha domain; cl02659"
                     /db_xref="CDD:295419"
     Region          60..86
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9QY24.1)"
     Region          84..147
                     /region_name="z-alpha"
                     /note="Adenosine deaminase z-alpha domain; cl02659"
                     /db_xref="CDD:295419"
     CDS             1..187
                     /gene="Zbp1"
                     /gene_synonym="2010010H03Rik; Dai; Dlm1; mZaDLM"
                     /coded_by="NM_001139519.1:148..711"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS50813.1"
                     /db_xref="GeneID:58203"
                     /db_xref="MGI:MGI:1927449"
ORIGIN      
        1 maeapvdlst gdnleqkilq vlsddggpvk igqlvkkcqv pkktlnqvly rlkkedrvss
       61 pepatwsigg aasgdgapai penssaqpsl derilrflea ngphralhia kalgmttake
      121 vnpllysmrn khllsydgqt wkiyhsrqeg qdivlpcspg cprthhvdqa glepteifll
      181 lpikfwd
//
LOCUS       NP_001396719             836 aa            linear   ROD 09-OCT-2023
DEFINITION  SWI/SNF-related matrix-associated actin-dependent regulator of
            chromatin subfamily A containing DEAD/H box 1 isoform 2 [Mus
            musculus].
ACCESSION   NP_001396719 XP_036021707
VERSION     NP_001396719.1
DBSOURCE    REFSEQ: accession NM_001409790.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 836)
  AUTHORS   Sachs P, Bergmaier P, Treutwein K and Mermoud JE.
  TITLE     The Conserved Chromatin Remodeler SMARCAD1 Interacts with TFIIIC
            and Architectural Proteins in Human and Mouse
  JOURNAL   Genes (Basel) 14 (9), 1793 (2023)
   PUBMED   37761933
  REMARK    GeneRIF: The Conserved Chromatin Remodeler SMARCAD1 Interacts with
            TFIIIC and Architectural Proteins in Human and Mouse.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 836)
  AUTHORS   Bedogni F and Hevner RF.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 836)
  AUTHORS   Niu Q, Wang W, Wei Z, Byeon B, Das AB, Chen BS and Wu WH.
  TITLE     Role of the ATP-dependent chromatin remodeling enzyme
            Fun30/Smarcad1 in the regulation of mRNA splicing
  JOURNAL   Biochem Biophys Res Commun 526 (2), 453-458 (2020)
   PUBMED   32234239
  REMARK    GeneRIF: Role of the ATP-dependent chromatin remodeling enzyme
            Fun30/Smarcad1 in the regulation of mRNA splicing.
REFERENCE   4  (residues 1 to 836)
  AUTHORS   Kazakevych J, Denizot J, Liebert A, Portovedo M, Mosavie M, Jain P,
            Stellato C, Fraser C, Correa RO, Celestine M, Mattiuz R, Okkenhaug
            H, Miller JR, Vinolo MAR, Veldhoen M and Varga-Weisz P.
  TITLE     Smarcad1 mediates microbiota-induced inflammation in mouse and
            coordinates gene expression in the intestinal epithelium
  JOURNAL   Genome Biol 21 (1), 64 (2020)
   PUBMED   32160911
  REMARK    GeneRIF: Smarcad1 mediates microbiota-induced inflammation in mouse
            and coordinates gene expression in the intestinal epithelium.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 836)
  AUTHORS   Sachs P, Ding D, Bergmaier P, Lamp B, Schlagheck C, Finkernagel F,
            Nist A, Stiewe T and Mermoud JE.
  TITLE     SMARCAD1 ATPase activity is required to silence endogenous
            retroviruses in embryonic stem cells
  JOURNAL   Nat Commun 10 (1), 1335 (2019)
   PUBMED   30902974
  REMARK    GeneRIF: These findings uncover a role for the enzymatic activity
            of SMARCAD1 in cooperating with KAP1 to silence Endogenous
            retroviruses.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 836)
  AUTHORS   Ben-Arie N, McCall AE, Berkman S, Eichele G, Bellen HJ and Zoghbi
            HY.
  TITLE     Evolutionary conservation of sequence and expression of the bHLH
            protein Atonal suggests a conserved role in neurogenesis
  JOURNAL   Hum Mol Genet 5 (9), 1207-1216 (1996)
   PUBMED   8872459
REFERENCE   7  (residues 1 to 836)
  AUTHORS   Villeneuve L, Jiang X, Turmel C, Kozak CA and Jolicoeur P.
  TITLE     Long-range mapping of Mis-2, a common provirus integration site
            identified in murine leukemia virus-induced thymomas and located
            160 kilobase pairs downstream of Myb
  JOURNAL   J Virol 67 (10), 5733-5739 (1993)
   PUBMED   8371338
REFERENCE   8  (residues 1 to 836)
  AUTHORS   Schoor M, Schuster-Gossler K and Gossler A.
  TITLE     The Etl-1 gene encodes a nuclear protein differentially expressed
            during early mouse development
  JOURNAL   Dev Dyn 197 (3), 227-237 (1993)
   PUBMED   8219362
REFERENCE   9  (residues 1 to 836)
  AUTHORS   Soininen R, Schoor M, Henseling U, Tepe C, Kisters-Woike B, Rossant
            J and Gossler A.
  TITLE     The mouse Enhancer trap locus 1 (Etl-1): a novel mammalian gene
            related to Drosophila and yeast transcriptional regulator genes
  JOURNAL   Mech Dev 39 (1-2), 111-123 (1992)
   PUBMED   1489724
REFERENCE   10 (residues 1 to 836)
  AUTHORS   O'Kane CJ and Gehring WJ.
  TITLE     Detection in situ of genomic regulatory elements in Drosophila
  JOURNAL   Proc Natl Acad Sci U S A 84 (24), 9123-9127 (1987)
   PUBMED   2827169
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC138622.4 and AC143330.4.
            
            On Jul 22, 2022 this sequence version replaced XP_036021707.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219382.236090.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..836
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 30.11 cM"
     Protein         1..836
                     /product="SWI/SNF-related matrix-associated
                     actin-dependent regulator of chromatin subfamily A
                     containing DEAD/H box 1 isoform 2"
                     /EC_number="3.6.4.12"
                     /note="enhancer trap locus homolog 1; ATP-dependent
                     helicase SMARCAD1; enhancer trap locus 1"
                     /calculated_mol_wt=95656
     Region          286..>808
                     /region_name="PLN03142"
                     /note="Probable chromatin-remodeling complex ATPase chain;
                     Provisional"
                     /db_xref="CDD:215601"
     Region          307..489
                     /region_name="DEXHc_SMARCAD1"
                     /note="DEXH-box helicase domain of SMARCAD1; cd17998"
                     /db_xref="CDD:350756"
     Site            order(334..340,373,438..439)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:350756"
     CDS             1..836
                     /gene="Smarcad1"
                     /gene_synonym="D6Pas1; etl-1; Etl1; mKIAA1122"
                     /coded_by="NM_001409790.1:818..3328"
                     /note="isoform 2 is encoded by transcript variant 6"
                     /db_xref="GeneID:13990"
                     /db_xref="MGI:MGI:95453"
ORIGIN      
        1 mdgaiaaall mfgdagggpr krklssssee ddvnddqsvk qprgdrgees nesaeassnw
       61 ekqesivlkl qkefpnfdkq elrevlkehe wmytealesl kvfaedqdvq casqsevtng
      121 kevarnqnys knatkikmkq kisvkpqngf nkkrkknvfn pkkavedsey dsgsdagssl
      181 dedyssceev medgykgkil hflqvssiae ltlipkcsqk kaqkitelrp fnnwealftk
      241 mskinglsed liwncktviq erdvvirlmn kcedisnklt kqvtmltgng ggwnreqpsl
      301 lnqslslkpy qkvglnwlal vhkhglngil ademglgkti qaiaflaylf qegnkgphli
      361 vvpastidnw lrevnlwcps lnvlcyygsq eerkqirfni hnkyedynvi vttyncaiss
      421 sddrslfrrl klnyaifdeg hmlknmgsir yqhlmtinar nrllltgtpv qnnllelmsl
      481 lnfvmphmfs sstseirrmf ssktkpadeq siyekeriah akqiikpfil rrvkeevlkl
      541 lppkkdriel camsekqeql ysglfnrlkk sinnleknte mcnvmmqlrk manhpllhrq
      601 yytpeklkem sqlmlkepth ceanpdlife dmevmtdfel hvlckqyqhi nsyqldmdli
      661 ldsgkfralg cilselkqkg drvvlfsqft mmldilevll khhqhrylrl dgktqiseri
      721 hlidefntdm difvfllstk agglginlts anvvilhdid cnpyndkqae drchrvgqtk
      781 evlviklisq gtieesmlki nqqklkleqd mttvdeadeg smpadiatll ktsmgl
//
LOCUS       NP_001351564             482 aa            linear   ROD 09-OCT-2023
DEFINITION  RNA-binding protein Nova-1 isoform 3 [Mus musculus].
ACCESSION   NP_001351564
VERSION     NP_001351564.1
DBSOURCE    REFSEQ: accession NM_001364635.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 482)
  AUTHORS   Tajima Y, Ito K, Yuan Y, Frank MO, Saito Y and Darnell RB.
  TITLE     NOVA1 acts on Impact to regulate hypothalamic function and
            translation in inhibitory neurons
  JOURNAL   Cell Rep 42 (2), 112050 (2023)
   PUBMED   36716149
  REMARK    GeneRIF: NOVA1 acts on Impact to regulate hypothalamic function and
            translation in inhibitory neurons.
REFERENCE   2  (residues 1 to 482)
  AUTHORS   Brahma MK, Xiao P, Popa M, Negueruela J, Vandenbempt V, Demine S,
            Cardozo AK and Gurzov EN.
  TITLE     Nova1 or Bim Deficiency in Pancreatic beta-Cells Does Not Alter
            Multiple Low-Dose Streptozotocin-Induced Diabetes and Diet-Induced
            Obesity in Mice
  JOURNAL   Nutrients 14 (18), 3866 (2022)
   PUBMED   36145242
  REMARK    GeneRIF: Nova1 or Bim Deficiency in Pancreatic beta-Cells Does Not
            Alter Multiple Low-Dose Streptozotocin-Induced Diabetes and
            Diet-Induced Obesity in Mice.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 482)
  AUTHORS   Krach F, Wheeler EC, Regensburger M, Boerstler T, Wend H, Vu AQ,
            Wang R, Reischl S, Boldt K, Batra R, Aigner S, Ravits J, Winkler J,
            Yeo GW and Winner B.
  TITLE     Aberrant NOVA1 function disrupts alternative splicing in early
            stages of amyotrophic lateral sclerosis
  JOURNAL   Acta Neuropathol 144 (3), 413-435 (2022)
   PUBMED   35778567
  REMARK    GeneRIF: Aberrant NOVA1 function disrupts alternative splicing in
            early stages of amyotrophic lateral sclerosis.
REFERENCE   4  (residues 1 to 482)
  AUTHORS   Li D, Shen M, Deng X and Bai Y.
  TITLE     MicroRNA miR-27a-3p accelerates cardiac hypertrophy by targeting
            neuro-oncological ventral antigen 1
  JOURNAL   Bioengineered 13 (4), 8982-8993 (2022)
   PUBMED   35348441
  REMARK    GeneRIF: MicroRNA miR-27a-3p accelerates cardiac hypertrophy by
            targeting neuro-oncological ventral antigen 1.
REFERENCE   5  (residues 1 to 482)
  AUTHORS   Johnson V, Junge HJ and Chen Z.
  TITLE     Temporal regulation of axonal repulsion by alternative splicing of
            a conserved microexon in mammalian Robo1 and Robo2
  JOURNAL   Elife 8, e46042 (2019)
   PUBMED   31392959
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 482)
  AUTHORS   Jensen KB, Dredge BK, Stefani G, Zhong R, Buckanovich RJ, Okano HJ,
            Yang YY and Darnell RB.
  TITLE     Nova-1 regulates neuron-specific alternative splicing and is
            essential for neuronal viability
  JOURNAL   Neuron 25 (2), 359-371 (2000)
   PUBMED   10719891
REFERENCE   7  (residues 1 to 482)
  AUTHORS   Yang YY, Yin GL and Darnell RB.
  TITLE     The neuronal RNA-binding protein Nova-2 is implicated as the
            autoantigen targeted in POMA patients with dementia
  JOURNAL   Proc Natl Acad Sci U S A 95 (22), 13254-13259 (1998)
   PUBMED   9789075
REFERENCE   8  (residues 1 to 482)
  AUTHORS   Fletcher CF, Okano HJ, Gilbert DJ, Yang Y, Yang C, Copeland NG,
            Jenkins NA and Darnell RB.
  TITLE     Mouse chromosomal locations of nine genes encoding homologs of
            human paraneoplastic neurologic disorder antigens
  JOURNAL   Genomics 45 (2), 313-319 (1997)
   PUBMED   9344654
REFERENCE   9  (residues 1 to 482)
  AUTHORS   Buckanovich RJ and Darnell RB.
  TITLE     The neuronal RNA binding protein Nova-1 recognizes specific RNA
            targets in vitro and in vivo
  JOURNAL   Mol Cell Biol 17 (6), 3194-3201 (1997)
   PUBMED   9154818
REFERENCE   10 (residues 1 to 482)
  AUTHORS   Buckanovich RJ, Yang YY and Darnell RB.
  TITLE     The onconeural antigen Nova-1 is a neuron-specific RNA-binding
            protein, the activity of which is inhibited by paraneoplastic
            antibodies
  JOURNAL   J Neurosci 16 (3), 1114-1122 (1996)
   PUBMED   8558240
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156636.2, AC108802.15 and CT009504.11.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.108273.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 21.46 cM"
     Protein         1..482
                     /product="RNA-binding protein Nova-1 isoform 3"
                     /note="RNA-binding protein Nova-1; ventral neuron-specific
                     protein 1; neuro-oncological ventral antigen 1"
                     /calculated_mol_wt=49021
     Region          48..120
                     /region_name="KH-I_NOVA_rpt1"
                     /note="first type I K homology (KH) RNA-binding domain
                     found in the family of neuro-oncological ventral antigen
                     (Nova); cd22435"
                     /db_xref="CDD:411863"
     Site            order(60..62,64..68,71..72,82..84,86..88,97)
                     /site_type="other"
                     /note="RNA binding site [nucleotide binding]"
                     /db_xref="CDD:411863"
     Region          147..216
                     /region_name="KH-I_NOVA_rpt2"
                     /note="second type I K homology (KH) RNA-binding domain
                     found in the family of neuro-oncological ventral antigen
                     (Nova); cd22436"
                     /db_xref="CDD:411864"
     Site            order(158..160,162..166,169..170,180..182,184..186,194)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:411864"
     Region          397..467
                     /region_name="KH-I_NOVA_rpt3"
                     /note="third type I K homology (KH) RNA-binding domain
                     found in the family of neuro-oncological ventral antigen
                     (Nova); cd09031"
                     /db_xref="CDD:411807"
     Site            order(405..406,408..410,412..416,419..420,430..436,438,
                     443,445)
                     /site_type="other"
                     /note="RNA binding site [nucleotide binding]"
                     /db_xref="CDD:411807"
     CDS             1..482
                     /gene="Nova1"
                     /gene_synonym="9430099M15Rik; G630039L02; Nova-1"
                     /coded_by="NM_001364635.1:17..1465"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="GeneID:664883"
                     /db_xref="MGI:MGI:104297"
ORIGIN      
        1 mmaaapiqqn gthtgvpidl dppdsrkrpl eappeagstk rtntgdgqyf lkvlipsyaa
       61 gsiigkggqt ivqlqketga tiklskskdf ypgttervcl iqgtiealna vhgfiaekir
      121 empqnvakte pvsilqpqtt vnpdrikqvk iivpnstagl iigkggatvk aimeqsgawv
      181 qlsqkpdgin lqervvtvsg epeqnrkave liiqkiqedp qsgsclnisy anvtgpvans
      241 nptgspyant aevlptaaaa agllghanla gvaafpavls gftgndlvai tsalntlasy
      301 gynlntlglg lsqaaatgal aaaaasanpa aaaanllaty aseasasgst aggtagtfal
      361 gslaaataat ngyfgaaspl aasailgtek stdgskdvve iavpenlvga ilgkggktlv
      421 eyqeltgari qiskkgefvp gtrnrkvtit gtpaatqaaq ylitqritye qgvraanpqk
      481 vg
//
LOCUS       NP_001349245             485 aa            linear   ROD 09-OCT-2023
DEFINITION  CUGBP Elav-like family member 4 isoform 36 [Mus musculus].
ACCESSION   NP_001349245
VERSION     NP_001349245.1
DBSOURCE    REFSEQ: accession NM_001362316.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 485)
  AUTHORS   Salamon I, Park Y, Miskic T, Kopic J, Matteson P, Page NF, Roque A,
            McAuliffe GW, Favate J, Garcia-Forn M, Shah P, Judas M, Millonig
            JH, Kostovic I, De Rubeis S, Hart RP, Krsnik Z and Rasin MR.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    GeneRIF: Celf4 controls mRNA translation underlying synaptic
            development in the prenatal mammalian neocortex.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 485)
  AUTHORS   Shen Y, Zhang C, Xiao K, Liu D and Xie G.
  TITLE     CELF4 regulates spine formation and depression-like behaviors of
            mice
  JOURNAL   Biochem Biophys Res Commun 605, 39-44 (2022)
   PUBMED   35306363
  REMARK    GeneRIF: CELF4 regulates spine formation and depression-like
            behaviors of mice.
REFERENCE   3  (residues 1 to 485)
  AUTHORS   Moreau MX, Saillour Y, Cwetsch AW, Pierani A and Causeret F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   4  (residues 1 to 485)
  AUTHORS   Li C, Li X, Bi Z, Sugino K, Wang G, Zhu T and Liu Z.
  TITLE     Comprehensive transcriptome analysis of cochlear spiral ganglion
            neurons at multiple ages
  JOURNAL   Elife 9, e50491 (2020)
   PUBMED   31913118
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 485)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 485)
  AUTHORS   Ladd AN, Taffet G, Hartley C, Kearney DL and Cooper TA.
  TITLE     Cardiac tissue-specific repression of CELF activity disrupts
            alternative splicing and causes cardiomyopathy
  JOURNAL   Mol Cell Biol 25 (14), 6267-6278 (2005)
   PUBMED   15988035
  REMARK    GeneRIF: CELF protein activity is required for normal alternative
            splicing in the heart in vivo and normal CELF-mediated alternative
            splicing regulation is in turn required for normal cardiac
            function.
REFERENCE   7  (residues 1 to 485)
  AUTHORS   Meins M, Schlickum S, Wilhelm C, Missbach J, Yadav S, Glaser B,
            Grzmil M, Burfeind P and Laccone F.
  TITLE     Identification and characterization of murine Brunol4, a new member
            of the elav/bruno family
  JOURNAL   Cytogenet Genome Res 97 (3-4), 254-260 (2002)
   PUBMED   12438720
  REMARK    GeneRIF: cloning and characterization
REFERENCE   8  (residues 1 to 485)
  AUTHORS   Ladd AN, Charlet N and Cooper TA.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   9  (residues 1 to 485)
  AUTHORS   Good PJ, Chen Q, Warner SJ and Herring DC.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
REFERENCE   10 (residues 1 to 485)
  AUTHORS   Yulug IG, Egan SE, See CG and Fisher EM.
  TITLE     Mapping GRB2, a signal transduction gene in the human and the mouse
  JOURNAL   Genomics 22 (2), 313-318 (1994)
   PUBMED   7806216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121094.8 and AC144938.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.2518784.1,
                                           SRR1660813.254341.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 13.92 cM"
     Protein         1..485
                     /product="CUGBP Elav-like family member 4 isoform 36"
                     /note="CUG-BP- and ETR-3-like factor 4; bruno-like protein
                     4; RNA-binding protein BRUNOL-4; bruno-like 4, RNA binding
                     protein"
                     /calculated_mol_wt=51688
     Region          18..39
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          49..135
                     /region_name="RRM1_CELF3_4_5_6"
                     /note="RNA recognition motif 1 (RRM1) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12632"
                     /db_xref="CDD:410041"
     Site            order(55,57,59..60,63,82,84,86,95..97,99,129,131)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410041"
     Region          121..149
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          151..231
                     /region_name="RRM2_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12635"
                     /db_xref="CDD:410043"
     Site            order(153,155,157..158,161,180,182,184,192..194,196,226,
                     228)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410043"
     Region          239..258
                     /region_name="Necessary for TNNT2 exon 5 inclusion.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSY6.2)"
     Region          416..474
                     /region_name="RRM_SF"
                     /note="RNA recognition motif (RRM) superfamily; cl17169"
                     /db_xref="CDD:450164"
     CDS             1..485
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /coded_by="NM_001362316.1:531..1988"
                     /note="isoform 36 is encoded by transcript variant 40"
                     /db_xref="GeneID:108013"
                     /db_xref="MGI:MGI:1932407"
ORIGIN      
        1 myikmatlan gqadnaslst nglgsspgsa ghmnglshsp gnpstipmkd hdaiklfigq
       61 iprnldekdl kplfeefgki yeltvlkdrf tgmhkgcafl tyceresalk aqsalheqkt
      121 lpgmnrpiqv kpadsesrgg ssclrqppsq drklfvgmln kqqseddvrr lfeafgniee
      181 ctilrgpdgn skgcafvkys shaeaqaain alhgsqtmpg assslvvkfa dtdkertmrr
      241 mqqmagqmgm fnpmaipfga ygayaqamqq qaalmasvaq ggylnpmaaf aaaqmqqmaa
      301 lnmnglaaap mtptsggstp pgitapavps ipspigvngf tglppqangq paaeavfang
      361 ihpypaqspt aadplqqaya gvqqyagpaa ypaaygqisq afpqpppmip qqqregpegc
      421 nlliyhlpqe fgdaelmqmf lpfgfvsfdn pasaqtaiqa mngfqigmkr lkvqlkrpkd
      481 anrpy
//
LOCUS       NP_001349255             475 aa            linear   ROD 09-OCT-2023
DEFINITION  CUGBP Elav-like family member 4 isoform 44 [Mus musculus].
ACCESSION   NP_001349255 XP_017173284
VERSION     NP_001349255.1
DBSOURCE    REFSEQ: accession NM_001362326.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 475)
  AUTHORS   Salamon I, Park Y, Miskic T, Kopic J, Matteson P, Page NF, Roque A,
            McAuliffe GW, Favate J, Garcia-Forn M, Shah P, Judas M, Millonig
            JH, Kostovic I, De Rubeis S, Hart RP, Krsnik Z and Rasin MR.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    GeneRIF: Celf4 controls mRNA translation underlying synaptic
            development in the prenatal mammalian neocortex.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 475)
  AUTHORS   Shen Y, Zhang C, Xiao K, Liu D and Xie G.
  TITLE     CELF4 regulates spine formation and depression-like behaviors of
            mice
  JOURNAL   Biochem Biophys Res Commun 605, 39-44 (2022)
   PUBMED   35306363
  REMARK    GeneRIF: CELF4 regulates spine formation and depression-like
            behaviors of mice.
REFERENCE   3  (residues 1 to 475)
  AUTHORS   Moreau MX, Saillour Y, Cwetsch AW, Pierani A and Causeret F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   4  (residues 1 to 475)
  AUTHORS   Li C, Li X, Bi Z, Sugino K, Wang G, Zhu T and Liu Z.
  TITLE     Comprehensive transcriptome analysis of cochlear spiral ganglion
            neurons at multiple ages
  JOURNAL   Elife 9, e50491 (2020)
   PUBMED   31913118
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 475)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 475)
  AUTHORS   Ladd AN, Taffet G, Hartley C, Kearney DL and Cooper TA.
  TITLE     Cardiac tissue-specific repression of CELF activity disrupts
            alternative splicing and causes cardiomyopathy
  JOURNAL   Mol Cell Biol 25 (14), 6267-6278 (2005)
   PUBMED   15988035
  REMARK    GeneRIF: CELF protein activity is required for normal alternative
            splicing in the heart in vivo and normal CELF-mediated alternative
            splicing regulation is in turn required for normal cardiac
            function.
REFERENCE   7  (residues 1 to 475)
  AUTHORS   Meins M, Schlickum S, Wilhelm C, Missbach J, Yadav S, Glaser B,
            Grzmil M, Burfeind P and Laccone F.
  TITLE     Identification and characterization of murine Brunol4, a new member
            of the elav/bruno family
  JOURNAL   Cytogenet Genome Res 97 (3-4), 254-260 (2002)
   PUBMED   12438720
  REMARK    GeneRIF: cloning and characterization
REFERENCE   8  (residues 1 to 475)
  AUTHORS   Ladd AN, Charlet N and Cooper TA.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   9  (residues 1 to 475)
  AUTHORS   Good PJ, Chen Q, Warner SJ and Herring DC.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
REFERENCE   10 (residues 1 to 475)
  AUTHORS   Yulug IG, Egan SE, See CG and Fisher EM.
  TITLE     Mapping GRB2, a signal transduction gene in the human and the mouse
  JOURNAL   Genomics 22 (2), 313-318 (1994)
   PUBMED   7806216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121094.8 and AC144938.3.
            
            On Apr 12, 2018 this sequence version replaced XP_017173284.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.178245.1,
                                           SRR1660813.62939.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..475
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 13.92 cM"
     Protein         1..475
                     /product="CUGBP Elav-like family member 4 isoform 44"
                     /note="CUG-BP- and ETR-3-like factor 4; bruno-like protein
                     4; RNA-binding protein BRUNOL-4; bruno-like 4, RNA binding
                     protein"
                     /calculated_mol_wt=50660
     Region          49..135
                     /region_name="RRM1_CELF3_4_5_6"
                     /note="RNA recognition motif 1 (RRM1) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12632"
                     /db_xref="CDD:410041"
     Site            order(55,57,59..60,63,82,84,86,95..97,99,129,131)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410041"
     Region          140..220
                     /region_name="RRM2_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12635"
                     /db_xref="CDD:410043"
     Site            order(142,144,146..147,150,169,171,173,181..183,185,215,
                     217)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410043"
     Region          406..464
                     /region_name="RRM_SF"
                     /note="RNA recognition motif (RRM) superfamily; cl17169"
                     /db_xref="CDD:450164"
     CDS             1..475
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /coded_by="NM_001362326.1:531..1958"
                     /note="isoform 44 is encoded by transcript variant 46"
                     /db_xref="GeneID:108013"
                     /db_xref="MGI:MGI:1932407"
ORIGIN      
        1 myikmatlan gqadnaslst nglgsspgsa ghmnglshsp gnpstipmkd hdaiklfigq
       61 iprnldekdl kplfeefgki yeltvlkdrf tgmhkgcafl tyceresalk aqsalheqkt
      121 lpgmnrpiqv kpadsesrgd rklfvgmlnk qqseddvrrl feafgnieec tilrgpdgns
      181 kgcafvkyss haeaqaaina lhgsqtmpga ssslvvkfad tdkertmrrm qqmagqmgmf
      241 npmaipfgay gayaqalmqq qaalmasvaq ggylnpmaaf aaaqmqqmaa lnmnglaaap
      301 mtptsggstp pgitapavps ipspigvngf tglppqangq paaeavfang ihpypaqspt
      361 aadplqqaya gvqqyagpaa ypaaygqisq afpqpppmip qqqregpegc nlliyhlpqe
      421 fgdaelmqmf lpfgfvsfdn pasaqtaiqa mngfqigmkr lkvqlkrpkd anrpy
//
LOCUS       NP_001154885             565 aa            linear   ROD 09-OCT-2023
DEFINITION  amino acid transporter heavy chain SLC3A2 isoform a [Mus musculus].
ACCESSION   NP_001154885
VERSION     NP_001154885.1
DBSOURCE    REFSEQ: accession NM_001161413.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 565)
  AUTHORS   Xiang P, Chen Q, Chen L, Lei J, Yuan Z, Hu H, Lu Y, Wang X, Wang T,
            Yu R, Zhang W, Zhang J, Yu C and Ma L.
  TITLE     Metabolite Neu5Ac triggers SLC3A2 degradation promoting vascular
            endothelial ferroptosis and aggravates atherosclerosis progression
            in ApoE-/-mice
  JOURNAL   Theranostics 13 (14), 4993-5016 (2023)
   PUBMED   37771765
  REMARK    GeneRIF: Metabolite Neu5Ac triggers SLC3A2 degradation promoting
            vascular endothelial ferroptosis and aggravates atherosclerosis
            progression in ApoE[-/-]mice.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 565)
  AUTHORS   Puris E, Saveleva L, de Sousa Maciel I, Kanninen KM, Auriola S and
            Fricker G.
  TITLE     Protein Expression of Amino Acid Transporters Is Altered in
            Isolated Cerebral Microvessels of 5xFAD Mouse Model of Alzheimer's
            Disease
  JOURNAL   Mol Neurobiol 60 (2), 732-748 (2023)
   PUBMED   36367657
  REMARK    GeneRIF: Protein Expression of Amino Acid Transporters Is Altered
            in Isolated Cerebral Microvessels of 5xFAD Mouse Model of
            Alzheimer's Disease.
REFERENCE   3  (residues 1 to 565)
  AUTHORS   Eom J, Choi J, Suh SS and Seo JB.
  TITLE     SLC3A2 and SLC7A2 Mediate the Exogenous Putrescine-Induced
            Adipocyte Differentiation
  JOURNAL   Mol Cells 45 (12), 963-975 (2022)
   PUBMED   36572564
  REMARK    GeneRIF: SLC3A2 and SLC7A2 Mediate the Exogenous Putrescine-Induced
            Adipocyte Differentiation.
REFERENCE   4  (residues 1 to 565)
  AUTHORS   Chen Q, Liu L and Ni S.
  TITLE     Screening of ferroptosis-related genes in sepsis-induced liver
            failure and analysis of immune correlation
  JOURNAL   PeerJ 10, e13757 (2022)
   PUBMED   35923893
  REMARK    GeneRIF: Screening of ferroptosis-related genes in sepsis-induced
            liver failure and analysis of immune correlation.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 565)
  AUTHORS   Salazar-Petres E, Pereira-Carvalho D, Lopez-Tello J and
            Sferruzzi-Perri AN.
  TITLE     Placental structure, function, and mitochondrial phenotype relate
            to fetal size in each fetal sex in micedagger
  JOURNAL   Biol Reprod 106 (6), 1292-1311 (2022)
   PUBMED   35293971
REFERENCE   6  (residues 1 to 565)
  AUTHORS   Rochelle JM, Watson ML, Oakey RJ and Seldin MF.
  TITLE     A linkage map of mouse chromosome 19: definition of comparative
            mapping relationships with human chromosomes 10 and 11 including
            the MEN1 locus
  JOURNAL   Genomics 14 (1), 26-31 (1992)
   PUBMED   1358795
REFERENCE   7  (residues 1 to 565)
  AUTHORS   Fowler KJ, Clouston WM, Fournier RE and Evans BA.
  TITLE     The relaxin gene is located on chromosome 19 in the mouse
  JOURNAL   FEBS Lett 292 (1-2), 183-186 (1991)
   PUBMED   1959604
REFERENCE   8  (residues 1 to 565)
  AUTHORS   Horlick KR, Cheng IC, Wong WT, Wakeland EK and Nick HS.
  TITLE     Mouse lipocortin I gene structure and chromosomal assignment: gene
            duplication and the origins of a gene family
  JOURNAL   Genomics 10 (2), 365-374 (1991)
   PUBMED   1676980
REFERENCE   9  (residues 1 to 565)
  AUTHORS   Chainani M, Sampsell B and Elliott RW.
  TITLE     Localization of the gene for plasma retinol binding protein to the
            distal half of mouse chromosome 19
  JOURNAL   Genomics 9 (2), 376-379 (1991)
   PUBMED   2004789
REFERENCE   10 (residues 1 to 565)
  AUTHORS   Levanon D, Hsieh CL, Francke U, Dawson PA, Ridgway ND, Brown MS and
            Goldstein JL.
  TITLE     cDNA cloning of human oxysterol-binding protein and localization of
            the gene to human chromosome 11 and mouse chromosome 19
  JOURNAL   Genomics 7 (1), 65-74 (1990)
   PUBMED   1970801
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC025794.9.
            
            Transcript Variant: This variant (1) represents the longer variant
            and encodes the longer isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK161280.1, SRR13948564.4926512.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..565
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 5.44 cM"
     Protein         1..565
                     /product="amino acid transporter heavy chain SLC3A2
                     isoform a"
                     /note="antigen identified by monoclonal antibodies 4F2;
                     4F2 cell-surface antigen heavy chain; CD98 heavy chain;
                     type II transmembrane protein; CD98 antigen; solute
                     carrier family 3 member 2; amino acid transporter heavy
                     chain SLC3A2"
                     /calculated_mol_wt=62109
     Region          79..157
                     /region_name="SLC3A2_N"
                     /note="Solute carrier family 3 member 2 N-terminus;
                     pfam16028"
                     /db_xref="CDD:435083"
     Region          139..468
                     /region_name="AmyAc_family"
                     /note="Alpha amylase catalytic domain family; cl38930"
                     /db_xref="CDD:453893"
     Site            order(244,279,281,312,371..372)
                     /site_type="active"
                     /db_xref="CDD:200451"
     Site            order(281,312,372)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:200451"
     CDS             1..565
                     /gene="Slc3a2"
                     /gene_synonym="4F2; 4F2HC; Cd98; Ly-10; Ly-m10; Ly10;
                     Mdu1; Mgp-2hc; NACAE"
                     /coded_by="NM_001161413.2:275..1972"
                     /note="isoform a is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS50381.1"
                     /db_xref="GeneID:17254"
                     /db_xref="MGI:MGI:96955"
ORIGIN      
        1 mdpeptehst dgvsvprqpp saqtgldvqv vsaagdsgtm sqdtevdmkd velnelepek
       61 qpmnaadgaa ageknglvki kvaedeteag vkftglskee llkvagspgw vrtrwallll
      121 fwlgwlgmla gavviivrap rcrelpvqrw whkgalyrig dlqafvgrda ggiaglkshl
      181 eylstlkvkg lvlgpihknq kdeinetdlk qinptlgsqe dfkdllqsak kksihiildl
      241 tpnyqgqnaw flpaqadiva tkmkealssw lqdgvdgfqf rdvgklmnap lylaewqnit
      301 knlsedrlli agtessdlqq ivnilestsd llltssylsn stftgertes lvtrflnatg
      361 sqwcswsvsq aglladfipd hllrlyqlll ftlpgtpvfs ygdelglqga lpgqpakapl
      421 mpwnessifh iprpvslnmt vkgqnedpgs lltqfrrlsd lrgkersllh gdfhalsssp
      481 dlfsyirhwd qnerylvvln frdsgrsarl gasnlpagis lpasakllls tdsarqsree
      541 dtslklenls lnpyeglllq fpfva
//
LOCUS       NP_034407                430 aa            linear   ROD 09-OCT-2023
DEFINITION  glial fibrillary acidic protein isoform 2 [Mus musculus].
ACCESSION   NP_034407
VERSION     NP_034407.2
DBSOURCE    REFSEQ: accession NM_010277.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 430)
  AUTHORS   Yammine SZ, Burns I, Gosio J, Peluso A, Merritt DM, Innes B, Coles
            BLK, Yan WR, Bader GD, Morshead CM and van der Kooy D.
  TITLE     Fate Specification of GFAP-Negative Primitive Neural Stem Cells and
            Their Progeny at Clonal Resolution
  JOURNAL   Stem Cells Dev 32 (19-20), 606-621 (2023)
   PUBMED   37551982
  REMARK    GeneRIF: Fate Specification of GFAP-Negative Primitive Neural Stem
            Cells and Their Progeny at Clonal Resolution.
REFERENCE   2  (residues 1 to 430)
  AUTHORS   Montillot C, Skutunova E, Ayushma, Dubied M, Lahmar A, Nguyen S,
            Peerally B, Prin F, Duffourd Y, Thauvin-Robinet C, Duplomb L, Wang
            H, Ansar M, Faivre L, Navarro N, Minocha S, Collins SC and Yalcin
            B.
  TITLE     Characterization of Vps13b-mutant mice reveals neuroanatomical and
            behavioral phenotypes with females less affected
  JOURNAL   Neurobiol Dis 185, 106259 (2023)
   PUBMED   37573958
REFERENCE   3  (residues 1 to 430)
  AUTHORS   Cao B, Xia Y, Cai Z, Wang Z, Tang C and Song Y.
  TITLE     Construction of a Brain-specific SLC23A2 Gene Knockout Mice Model
  JOURNAL   Neuroscience 524, 137-148 (2023)
   PUBMED   37330196
REFERENCE   4  (residues 1 to 430)
  AUTHORS   Hu M, Bodnar B, Zhang Y, Xie F, Li F, Li S, Zhao J, Zhao R,
            Gedupoori N, Mo Y, Lin L, Li X, Meng W, Yang X, Wang H, Barbe MF,
            Srinivasan S, Bethea JR, Mo X, Xu H and Hu W.
  TITLE     Defective neurite elongation and branching in Nibp/Trappc9
            deficient zebrafish and mice
  JOURNAL   Int J Biol Sci 19 (10), 3226-3248 (2023)
   PUBMED   37416774
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 430)
  AUTHORS   Li J, Jiang H, Mu Y, Wei Z, Ma A, Sun M, Zhao J, Zhu C and Chen X.
  TITLE     SRSF10 regulates proliferation of neural progenitor cells and
            affects neurogenesis in developing mouse neocortex
  JOURNAL   iScience 26 (7), 107042 (2023)
   PUBMED   37360696
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 430)
  AUTHORS   Miragall F, Hwang TK, Traub O, Hertzberg EL and Dermietzel R.
  TITLE     Expression of connexins in the developing olfactory system of the
            mouse
  JOURNAL   J Comp Neurol 325 (3), 359-378 (1992)
   PUBMED   1332989
REFERENCE   7  (residues 1 to 430)
  AUTHORS   Nonaka M, Matsuda Y, Shiroishi T, Moriwaki K, Nonaka M and
            Natsuume-Sakai S.
  TITLE     Molecular cloning of mouse beta 2-glycoprotein I and mapping of the
            gene to chromosome 11
  JOURNAL   Genomics 13 (4), 1082-1087 (1992)
   PUBMED   1339387
REFERENCE   8  (residues 1 to 430)
  AUTHORS   Dietrich W, Katz H, Lincoln SE, Shin HS, Friedman J, Dracopoli NC
            and Lander ES.
  TITLE     A genetic map of the mouse suitable for typing intraspecific
            crosses
  JOURNAL   Genetics 131 (2), 423-447 (1992)
   PUBMED   1353738
REFERENCE   9  (residues 1 to 430)
  AUTHORS   Karolyi IJ, Guenet JL, Rey-Campos J and Camper SA.
  TITLE     The gene coding for variant hepatic nuclear factor 1 (Tcf-2), maps
            between the Edp-1 and Erba genes on mouse chromosome 11
  JOURNAL   Mamm Genome 3 (3), 184-185 (1992)
   PUBMED   1352161
REFERENCE   10 (residues 1 to 430)
  AUTHORS   Dyson PJ, de Smet C, Knight AM, Simon-Chazottes D, Guenet JL and
            Boon T.
  TITLE     Mapping of the genes encoding tum- transplantation antigens P91A,
            P35B, and P198
  JOURNAL   Immunogenetics 35 (5), 316-323 (1992)
   PUBMED   1348494
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC139357.1, AK079577.1, CX223233.1, BE651678.1 and AI835063.1.
            
            On Dec 24, 2005 this sequence version replaced NP_034407.1.
            
            Transcript Variant: This variant (2) differs in the 3' coding
            region and 3' UTR, compared to variant 1, which results in a
            protein (isoform 2) with a shorter and distinct C-terminus when
            compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC139357.1, AK079577.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..430
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 66.48 cM"
     Protein         1..430
                     /product="glial fibrillary acidic protein isoform 2"
                     /note="intermediate filament protein"
                     /calculated_mol_wt=49769
     Region          1..69
                     /region_name="Head"
                     /note="propagated from UniProtKB/Swiss-Prot (P03995.4)"
     Region          4..63
                     /region_name="Filament_head"
                     /note="Intermediate filament head (DNA binding) region;
                     pfam04732"
                     /db_xref="CDD:428095"
     Site            7
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by AURKB and ROCK1.
                     /evidence=ECO:0000250|UniProtKB:P14136; propagated from
                     UniProtKB/Swiss-Prot (P03995.4)"
     Site            11
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0007744|PubMed:24129315; propagated from
                     UniProtKB/Swiss-Prot (P03995.4)"
     Site            12
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by AURKB and ROCK1.
                     /evidence=ECO:0000250|UniProtKB:P14136; propagated from
                     UniProtKB/Swiss-Prot (P03995.4)"
     Site            20
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0007744|PubMed:24129315; propagated from
                     UniProtKB/Swiss-Prot (P03995.4)"
     Site            35
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by AURKB and ROCK1.
                     /evidence=ECO:0000250|UniProtKB:P14136; propagated from
                     UniProtKB/Swiss-Prot (P03995.4)"
     Site            40
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:16452087; propagated from
                     UniProtKB/Swiss-Prot (P03995.4)"
     Region          65..373
                     /region_name="Filament"
                     /note="Intermediate filament protein; pfam00038"
                     /db_xref="CDD:425436"
     Region          70..101
                     /region_name="Coil 1A"
                     /note="propagated from UniProtKB/Swiss-Prot (P03995.4)"
     Site            79
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P47819; propagated from
                     UniProtKB/Swiss-Prot (P03995.4)"
     Region          102..112
                     /region_name="Linker 1"
                     /note="propagated from UniProtKB/Swiss-Prot (P03995.4)"
     Site            107
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P47819; propagated from
                     UniProtKB/Swiss-Prot (P03995.4)"
     Region          113..211
                     /region_name="Coil 1B"
                     /note="propagated from UniProtKB/Swiss-Prot (P03995.4)"
     Site            147
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P47819; propagated from
                     UniProtKB/Swiss-Prot (P03995.4)"
     Region          212..227
                     /region_name="Linker 12"
                     /note="propagated from UniProtKB/Swiss-Prot (P03995.4)"
     Region          228..249
                     /region_name="Coil 2A"
                     /note="propagated from UniProtKB/Swiss-Prot (P03995.4)"
     Region          250..253
                     /region_name="Linker 2"
                     /note="propagated from UniProtKB/Swiss-Prot (P03995.4)"
     Region          254..374
                     /region_name="Coil 2B"
                     /note="propagated from UniProtKB/Swiss-Prot (P03995.4)"
     Site            266
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P47819; propagated from
                     UniProtKB/Swiss-Prot (P03995.4)"
     Site            320
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P47819; propagated from
                     UniProtKB/Swiss-Prot (P03995.4)"
     Region          375..430
                     /region_name="Tail"
                     /note="propagated from UniProtKB/Swiss-Prot (P03995.4)"
     Site            380
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P47819; propagated from
                     UniProtKB/Swiss-Prot (P03995.4)"
     Site            382
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P47819; propagated from
                     UniProtKB/Swiss-Prot (P03995.4)"
     CDS             1..430
                     /gene="Gfap"
                     /coded_by="NM_010277.3:84..1376"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS25507.1"
                     /db_xref="GeneID:14580"
                     /db_xref="MGI:MGI:95697"
ORIGIN      
        1 merrritsar rsyasetvvr glgpsrqlgt mprfslsrmt pplparvdfs lagalnagfk
       61 etraseraem melndrfasy iekvrfleqq nkalaaelnq lrakeptkla dvyqaelrel
      121 rlrldqltan sarleverdn faqdlgtlrq klqdetnlrl eaennlaayr qeadeatlar
      181 vdlerkvesl eeeiqflrki yeeevrelre qlaqqqvhve mdvakpdlta alreirtqye
      241 avatsnmqet eewyrskfad ltdaasrnae llrqakhean dyrrqlqalt cdleslrgtn
      301 eslerqmreq eerharesas yqealarlee egqslkeema rhlqeyqdll nvklaldiei
      361 atyrkllege enritipvqt fsnlqirets ldtksvsegh lkrnivvktv emrdgevikd
      421 skqehkdvvm
//
LOCUS       NP_001240321             836 aa            linear   ROD 09-OCT-2023
DEFINITION  SWI/SNF-related matrix-associated actin-dependent regulator of
            chromatin subfamily A containing DEAD/H box 1 isoform 2 [Mus
            musculus].
ACCESSION   NP_001240321
VERSION     NP_001240321.1
DBSOURCE    REFSEQ: accession NM_001253392.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 836)
  AUTHORS   Sachs P, Bergmaier P, Treutwein K and Mermoud JE.
  TITLE     The Conserved Chromatin Remodeler SMARCAD1 Interacts with TFIIIC
            and Architectural Proteins in Human and Mouse
  JOURNAL   Genes (Basel) 14 (9), 1793 (2023)
   PUBMED   37761933
  REMARK    GeneRIF: The Conserved Chromatin Remodeler SMARCAD1 Interacts with
            TFIIIC and Architectural Proteins in Human and Mouse.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 836)
  AUTHORS   Bedogni F and Hevner RF.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 836)
  AUTHORS   Niu Q, Wang W, Wei Z, Byeon B, Das AB, Chen BS and Wu WH.
  TITLE     Role of the ATP-dependent chromatin remodeling enzyme
            Fun30/Smarcad1 in the regulation of mRNA splicing
  JOURNAL   Biochem Biophys Res Commun 526 (2), 453-458 (2020)
   PUBMED   32234239
  REMARK    GeneRIF: Role of the ATP-dependent chromatin remodeling enzyme
            Fun30/Smarcad1 in the regulation of mRNA splicing.
REFERENCE   4  (residues 1 to 836)
  AUTHORS   Kazakevych J, Denizot J, Liebert A, Portovedo M, Mosavie M, Jain P,
            Stellato C, Fraser C, Correa RO, Celestine M, Mattiuz R, Okkenhaug
            H, Miller JR, Vinolo MAR, Veldhoen M and Varga-Weisz P.
  TITLE     Smarcad1 mediates microbiota-induced inflammation in mouse and
            coordinates gene expression in the intestinal epithelium
  JOURNAL   Genome Biol 21 (1), 64 (2020)
   PUBMED   32160911
  REMARK    GeneRIF: Smarcad1 mediates microbiota-induced inflammation in mouse
            and coordinates gene expression in the intestinal epithelium.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 836)
  AUTHORS   Sachs P, Ding D, Bergmaier P, Lamp B, Schlagheck C, Finkernagel F,
            Nist A, Stiewe T and Mermoud JE.
  TITLE     SMARCAD1 ATPase activity is required to silence endogenous
            retroviruses in embryonic stem cells
  JOURNAL   Nat Commun 10 (1), 1335 (2019)
   PUBMED   30902974
  REMARK    GeneRIF: These findings uncover a role for the enzymatic activity
            of SMARCAD1 in cooperating with KAP1 to silence Endogenous
            retroviruses.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 836)
  AUTHORS   Ben-Arie N, McCall AE, Berkman S, Eichele G, Bellen HJ and Zoghbi
            HY.
  TITLE     Evolutionary conservation of sequence and expression of the bHLH
            protein Atonal suggests a conserved role in neurogenesis
  JOURNAL   Hum Mol Genet 5 (9), 1207-1216 (1996)
   PUBMED   8872459
REFERENCE   7  (residues 1 to 836)
  AUTHORS   Villeneuve L, Jiang X, Turmel C, Kozak CA and Jolicoeur P.
  TITLE     Long-range mapping of Mis-2, a common provirus integration site
            identified in murine leukemia virus-induced thymomas and located
            160 kilobase pairs downstream of Myb
  JOURNAL   J Virol 67 (10), 5733-5739 (1993)
   PUBMED   8371338
REFERENCE   8  (residues 1 to 836)
  AUTHORS   Schoor M, Schuster-Gossler K and Gossler A.
  TITLE     The Etl-1 gene encodes a nuclear protein differentially expressed
            during early mouse development
  JOURNAL   Dev Dyn 197 (3), 227-237 (1993)
   PUBMED   8219362
REFERENCE   9  (residues 1 to 836)
  AUTHORS   Soininen R, Schoor M, Henseling U, Tepe C, Kisters-Woike B, Rossant
            J and Gossler A.
  TITLE     The mouse Enhancer trap locus 1 (Etl-1): a novel mammalian gene
            related to Drosophila and yeast transcriptional regulator genes
  JOURNAL   Mech Dev 39 (1-2), 111-123 (1992)
   PUBMED   1489724
REFERENCE   10 (residues 1 to 836)
  AUTHORS   O'Kane CJ and Gehring WJ.
  TITLE     Detection in situ of genomic regulatory elements in Drosophila
  JOURNAL   Proc Natl Acad Sci U S A 84 (24), 9123-9127 (1987)
   PUBMED   2827169
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK147884.1, X69942.1 and AK122454.1.
            
            Transcript Variant: This variant (2) lacks an alternate exon which
            results in the use of a downstream start codon, compared to variant
            1. The resulting protein (isoform 2) is shorter when it is compared
            to isoform 1. Variants 2 and 6 both encode the same isoform (2).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC042442.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..836
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 30.11 cM"
     Protein         1..836
                     /product="SWI/SNF-related matrix-associated
                     actin-dependent regulator of chromatin subfamily A
                     containing DEAD/H box 1 isoform 2"
                     /EC_number="3.6.4.12"
                     /note="enhancer trap locus homolog 1; ATP-dependent
                     helicase SMARCAD1; enhancer trap locus 1"
                     /calculated_mol_wt=95656
     Region          286..>808
                     /region_name="PLN03142"
                     /note="Probable chromatin-remodeling complex ATPase chain;
                     Provisional"
                     /db_xref="CDD:215601"
     Region          307..489
                     /region_name="DEXHc_SMARCAD1"
                     /note="DEXH-box helicase domain of SMARCAD1; cd17998"
                     /db_xref="CDD:350756"
     Site            order(334..340,373,438..439)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:350756"
     CDS             1..836
                     /gene="Smarcad1"
                     /gene_synonym="D6Pas1; etl-1; Etl1; mKIAA1122"
                     /coded_by="NM_001253392.1:440..2950"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="GeneID:13990"
                     /db_xref="MGI:MGI:95453"
ORIGIN      
        1 mdgaiaaall mfgdagggpr krklssssee ddvnddqsvk qprgdrgees nesaeassnw
       61 ekqesivlkl qkefpnfdkq elrevlkehe wmytealesl kvfaedqdvq casqsevtng
      121 kevarnqnys knatkikmkq kisvkpqngf nkkrkknvfn pkkavedsey dsgsdagssl
      181 dedyssceev medgykgkil hflqvssiae ltlipkcsqk kaqkitelrp fnnwealftk
      241 mskinglsed liwncktviq erdvvirlmn kcedisnklt kqvtmltgng ggwnreqpsl
      301 lnqslslkpy qkvglnwlal vhkhglngil ademglgkti qaiaflaylf qegnkgphli
      361 vvpastidnw lrevnlwcps lnvlcyygsq eerkqirfni hnkyedynvi vttyncaiss
      421 sddrslfrrl klnyaifdeg hmlknmgsir yqhlmtinar nrllltgtpv qnnllelmsl
      481 lnfvmphmfs sstseirrmf ssktkpadeq siyekeriah akqiikpfil rrvkeevlkl
      541 lppkkdriel camsekqeql ysglfnrlkk sinnleknte mcnvmmqlrk manhpllhrq
      601 yytpeklkem sqlmlkepth ceanpdlife dmevmtdfel hvlckqyqhi nsyqldmdli
      661 ldsgkfralg cilselkqkg drvvlfsqft mmldilevll khhqhrylrl dgktqiseri
      721 hlidefntdm difvfllstk agglginlts anvvilhdid cnpyndkqae drchrvgqtk
      781 evlviklisq gtieesmlki nqqklkleqd mttvdeadeg smpadiatll ktsmgl
//
LOCUS       NP_034903                414 aa            linear   ROD 09-OCT-2023
DEFINITION  methyl-CpG-binding domain protein 2 isoform 1 [Mus musculus].
ACCESSION   NP_034903 XP_001000950
VERSION     NP_034903.2
DBSOURCE    REFSEQ: accession NM_010773.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 414)
  AUTHORS   Duan W, Huang J, Wasti B, Chen Z, Yuan Y, He Y, Li D, Jia J, Liu S,
            Liu Y, Ma L, Zeng Q, Zhu L, Li J, Zhang X and Xiang X.
  TITLE     miR-146a-3p as a potential novel therapeutic by targeting MBD2 to
            mediate Th17 differentiation in Th17 predominant neutrophilic
            severe asthma
  JOURNAL   Clin Exp Med 23 (6), 2839-2854 (2023)
   PUBMED   36961677
  REMARK    GeneRIF: miR-146a-3p as a potential novel therapeutic by targeting
            MBD2 to mediate Th17 differentiation in Th17 predominant
            neutrophilic severe asthma.
REFERENCE   2  (residues 1 to 414)
  AUTHORS   Lax E, Do Carmo S, Enuka Y, Sapozhnikov DM, Welikovitch LA, Mahmood
            N, Rabbani SA, Wang L, Britt JP, Hancock WW, Yarden Y and Szyf M.
  TITLE     Methyl-CpG binding domain 2 (Mbd2) is an epigenetic regulator of
            autism-risk genes and cognition
  JOURNAL   Transl Psychiatry 13 (1), 259 (2023)
   PUBMED   37443311
  REMARK    GeneRIF: Methyl-CpG binding domain 2 (Mbd2) is an epigenetic
            regulator of autism-risk genes and cognition.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 414)
  AUTHORS   Jiang Y, Li L, Pan Q, Du X, Han Q, Ling F, Li R, Mai L, Huang J,
            Chu S and Ma L.
  TITLE     Methyl-cpg-binding Domain Protein 2 Silencing Inhibits Th17
            Differentiation of CD4+T cells Induced by Ovalbumin
  JOURNAL   Iran J Immunol 20 (1), 45-56 (2023)
   PUBMED   36932919
  REMARK    GeneRIF: Methyl-cpg-binding Domain Protein 2 Silencing Inhibits
            Th17 Differentiation of CD4+T cells Induced by Ovalbumin.
REFERENCE   4  (residues 1 to 414)
  AUTHORS   Wu GR, Zhou M, Wang Y, Zhou Q, Zhang L, He L, Zhang S, Yu Q, Xu Y,
            Zhao J, Xiong W and Wang CY.
  TITLE     Blockade of Mbd2 by siRNA-loaded liposomes protects mice against
            OVA-induced allergic airway inflammation via repressing M2
            macrophage production
  JOURNAL   Front Immunol 13, 930103 (2022)
   PUBMED   36090987
  REMARK    GeneRIF: Blockade of Mbd2 by siRNA-loaded liposomes protects mice
            against OVA-induced allergic airway inflammation via repressing M2
            macrophage production.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 414)
  AUTHORS   Ai K, Pan J, Zhang P, Li H, He Z, Zhang H, Li X, Li Y, Yi L, Kang
            Y, Wang Y, Xiang X, Chai X and Zhang D.
  TITLE     Methyl-CpG-binding domain protein 2 contributes to renal fibrosis
            through promoting polarized M1 macrophages
  JOURNAL   Cell Death Dis 13 (2), 125 (2022)
   PUBMED   35136032
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 414)
  AUTHORS   Klinowska TC, Alexander CM, Georges-Labouesse E, Van der Neut R,
            Kreidberg JA, Jones CJ, Sonnenberg A and Streuli CH.
  TITLE     Epithelial development and differentiation in the mammary gland is
            not dependent on alpha 3 or alpha 6 integrin subunits
  JOURNAL   Dev Biol 233 (2), 449-467 (2001)
   PUBMED   11336507
REFERENCE   7  (residues 1 to 414)
  AUTHORS   Hendrich B, Guy J, Ramsahoye B, Wilson VA and Bird A.
  TITLE     Closely related proteins MBD2 and MBD3 play distinctive but
            interacting roles in mouse development
  JOURNAL   Genes Dev 15 (6), 710-723 (2001)
   PUBMED   11274056
REFERENCE   8  (residues 1 to 414)
  AUTHORS   Guy J, Hendrich B, Holmes M, Martin JE and Bird A.
  TITLE     A mouse Mecp2-null mutation causes neurological symptoms that mimic
            Rett syndrome
  JOURNAL   Nat Genet 27 (3), 322-326 (2001)
   PUBMED   11242117
REFERENCE   9  (residues 1 to 414)
  AUTHORS   Hendrich B, Abbott C, McQueen H, Chambers D, Cross S and Bird A.
  TITLE     Genomic structure and chromosomal mapping of the murine and human
            Mbd1, Mbd2, Mbd3, and Mbd4 genes
  JOURNAL   Mamm Genome 10 (9), 906-912 (1999)
   PUBMED   10441743
REFERENCE   10 (residues 1 to 414)
  AUTHORS   Hendrich B and Bird A.
  TITLE     Identification and characterization of a family of mammalian
            methyl-CpG binding proteins
  JOURNAL   Mol Cell Biol 18 (11), 6538-6547 (1998)
   PUBMED   9774669
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX239662.1, AF072243.1, AK147008.1 and BU757659.1.
            
            On Dec 30, 2008 this sequence version replaced NP_034903.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC046607.1, AF072243.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..414
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 44.54 cM"
     Protein         1..414
                     /product="methyl-CpG-binding domain protein 2 isoform 1"
                     /note="methyl-CpG-binding protein MBD2; testis-specific
                     methyl-CpG binding protein 2"
                     /calculated_mol_wt=43370
     Region          1..163
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2E1.2)"
     Region          1..152
                     /region_name="Required for interaction with DHX9 and
                     PRMT5. /evidence=ECO:0000250|UniProtKB:Q9UBB5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2E1.2)"
     Region          154..217
                     /region_name="MeCP2_MBD"
                     /note="MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a
                     protein family that share the methyl-CpG-binding domain
                     (MBD). The MBD, consists of about 70 residues and is
                     defined as the minimal region required for binding to
                     methylated DNA by a methyl-CpG-binding...; cd01396"
                     /db_xref="CDD:238690"
     Site            order(165,167,169,177,179,188,191,195)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238690"
     Site            184
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UBB5; propagated from
                     UniProtKB/Swiss-Prot (Q9Z2E1.2)"
     Region          217..244
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2E1.2)"
     Region          229..295
                     /region_name="MBDa"
                     /note="p55-binding region of Methyl-CpG-binding domain
                     proteins MBD; pfam16564"
                     /db_xref="CDD:435433"
     Region          299..390
                     /region_name="MBD_C"
                     /note="C-terminal domain of methyl-CpG binding protein 2
                     and 3; pfam14048"
                     /db_xref="CDD:433673"
     Site            410
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UBB5; propagated from
                     UniProtKB/Swiss-Prot (Q9Z2E1.2)"
     CDS             1..414
                     /gene="Mbd2"
                     /gene_synonym="MBD2a"
                     /coded_by="NM_010773.2:126..1370"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS29335.1"
                     /db_xref="GeneID:17191"
                     /db_xref="MGI:MGI:1333813"
ORIGIN      
        1 mrahpgggrc cpeqeegesa aggsgaggds aieqggqgsa lapspvsgvr regargggrg
       61 rgrwkqaarg ggvcgrgrgr grgrgrgrgr grgrgrpqsg gsglggdggg gaggcgggsg
      121 ggvaprrdpv pfpsgssgpg prgpratesg krmdcpalpp gwkkeevirk sglsagksdv
      181 yyfspsgkkf rskpqlaryl gnavdlssfd frtgkmmpsk lqknkqrlrn dplnqnkgkp
      241 dlnttlpirq tasifkqpvt kftnhpsnkv ksdpqrmneq prqlfwekrl qglsasdvte
      301 qiiktmelpk glqgvgpgsn detllsavas alhtssapit gqvsaavekn pavwlntsqp
      361 lckafivtde dirkqeervq qvrkkleeal madilsraad teevdidmds gdea
//
LOCUS       NP_001394530             360 aa            linear   ROD 09-OCT-2023
DEFINITION  mitogen-activated protein kinase 10 isoform 14 [Mus musculus].
ACCESSION   NP_001394530
VERSION     NP_001394530.1
DBSOURCE    REFSEQ: accession NM_001407601.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 360)
  AUTHORS   Priego M, Noriega L, Kalinin S, Hoffman LM, Feinstein DL and
            Morfini G.
  TITLE     Genetic deletion of c-Jun amino-terminal kinase 3 (JNK3) modestly
            increases disease severity in a mouse model of multiple sclerosis
  JOURNAL   J Neuroimmunol 382, 578152 (2023)
   PUBMED   37454525
  REMARK    GeneRIF: Genetic deletion of c-Jun amino-terminal kinase 3 (JNK3)
            modestly increases disease severity in a mouse model of multiple
            sclerosis.
REFERENCE   2  (residues 1 to 360)
  AUTHORS   Liu F, Deng Y, Zhao Y, Li Z, Gao J, Zhang Y, Yang X, Liu Y and Xia
            Y.
  TITLE     Time series RNA-seq analysis identifies MAPK10 as a critical gene
            in diabetes mellitus-induced atrial fibrillation in mice
  JOURNAL   J Mol Cell Cardiol 168, 70-82 (2022)
   PUBMED   35489387
  REMARK    GeneRIF: Time series RNA-seq analysis identifies MAPK10 as a
            critical gene in diabetes mellitus-induced atrial fibrillation in
            mice.
REFERENCE   3  (residues 1 to 360)
  AUTHORS   Cunningham JG, Scripter JD, Nti SA and Tucker ES.
  TITLE     Early construction of the thalamocortical axon pathway requires
            c-Jun N-terminal kinase signaling within the ventral forebrain
  JOURNAL   Dev Dyn 251 (3), 459-480 (2022)
   PUBMED   34494344
REFERENCE   4  (residues 1 to 360)
  AUTHORS   Goodwani S, Fernandez C, Acton PJ, Buggia-Prevot V, McReynolds ML,
            Ma J, Hu CH, Hamby ME, Jiang Y, Le K, Soth MJ, Jones P and Ray WJ.
  TITLE     Dual Leucine Zipper Kinase Is Constitutively Active in the Adult
            Mouse Brain and Has Both Stress-Induced and Homeostatic Functions
  JOURNAL   Int J Mol Sci 21 (14), 4849 (2020)
   PUBMED   32659913
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 360)
  AUTHORS   Loughran G, Chou MY, Ivanov IP, Jungreis I, Kellis M, Kiran AM,
            Baranov PV and Atkins JF.
  TITLE     Evidence of efficient stop codon readthrough in four mammalian
            genes
  JOURNAL   Nucleic Acids Res 42 (14), 8928-8938 (2014)
   PUBMED   25013167
REFERENCE   6  (residues 1 to 360)
  AUTHORS   Beier H and Grimm M.
  TITLE     Misreading of termination codons in eukaryotes by natural nonsense
            suppressor tRNAs
  JOURNAL   Nucleic Acids Res 29 (23), 4767-4782 (2001)
   PUBMED   11726686
  REMARK    Review article
REFERENCE   7  (residues 1 to 360)
  AUTHORS   Yang DD, Kuan CY, Whitmarsh AJ, Rincon M, Zheng TS, Davis RJ, Rakic
            P and Flavell RA.
  TITLE     Absence of excitotoxicity-induced apoptosis in the hippocampus of
            mice lacking the Jnk3 gene
  JOURNAL   Nature 389 (6653), 865-870 (1997)
   PUBMED   9349820
REFERENCE   8  (residues 1 to 360)
  AUTHORS   Casanova E, Garate C, Ovalle S, Calvo P and Chinchetru MA.
  TITLE     Identification of four splice variants of the mouse
            stress-activated protein kinase JNK/SAPK alpha-isoform
  JOURNAL   Neuroreport 7 (7), 1320-1324 (1996)
   PUBMED   8817558
REFERENCE   9  (residues 1 to 360)
  AUTHORS   Martin JH, Mohit AA and Miller CA.
  TITLE     Developmental expression in the mouse nervous system of the p493F12
            SAP kinase
  JOURNAL   Brain Res Mol Brain Res 35 (1-2), 47-57 (1996)
   PUBMED   8717339
REFERENCE   10 (residues 1 to 360)
  AUTHORS   Suzuki J, Yoshida S, Chen ZL, Momota Y, Kato K, Hirata A and
            Shiosaka S.
  TITLE     Ontogeny of neuropsin mRNA expression in the mouse brain
  JOURNAL   Neurosci Res 23 (4), 345-351 (1995)
   PUBMED   8602273
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC160244.11, AC123664.15,
            AC137121.9 and AC125252.7.
            
            Summary: The protein encoded by this gene is a member of the MAP
            kinase family. MAP kinases act as integration points for multiple
            biochemical signals, and thus are involved in a wide variety of
            cellular processes, such as proliferation, differentiation,
            transcription regulation and development. This kinase is
            specifically expressed in a subset of neurons in the nervous system
            and is activated by threonine and tyrosine phosphorylation.
            Targeted deletion of this gene in mice suggests that it may have a
            role in stress-induced neuronal apoptosis. Alternatively spliced
            transcript variants encoding different isoforms have been found for
            this gene. A recent study provided evidence for translational
            readthrough in this gene, and expression of an additional
            C-terminally extended isoform via the use of an alternative
            in-frame translation termination codon. [provided by RefSeq, Dec
            2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784646.1044404.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..360
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 49.61 cM"
     Protein         1..360
                     /product="mitogen-activated protein kinase 10 isoform 14"
                     /EC_number="2.7.11.24"
                     /note="JNK3 beta1 protein kinase; JNK3 beta2 protein
                     kinase; MAP kinase 10; MAP kinase p49 3F12; c-Jun
                     N-terminal kinase 3; stress-activated protein kinase JNK3;
                     SAPK/Erk/kinase 2"
                     /calculated_mol_wt=41177
     Region          25..336
                     /region_name="STKc_JNK"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     c-Jun N-terminal Kinase; cd07850"
                     /db_xref="CDD:270840"
     Site            order(32..38,40,53,55,72,86,108..114,116..117,151,153,
                     155..156,158,168..169,172,183,185..188,190)
                     /site_type="active"
                     /db_xref="CDD:270840"
     Site            order(32..38,40,53,55,86,108..114,158,168)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270840"
     Site            order(72,116,151,153,172,183,185..188,190)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270840"
     Site            order(112,118,127,130,159..163,299..300,302,305)
                     /site_type="other"
                     /note="KIM docking site [polypeptide binding]"
                     /db_xref="CDD:270840"
     Site            order(168..178,182..190)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270840"
     CDS             1..360
                     /gene="Mapk10"
                     /gene_synonym="C230008H04Rik; JNK3; JNK3B1; JNK3B2;
                     p493F12; p54bSAPK; SAPK(beta); Serk2"
                     /coded_by="NM_001407601.1:658..1740"
                     /note="isoform 14 is encoded by transcript variant 24"
                     /db_xref="GeneID:26414"
                     /db_xref="MGI:MGI:1346863"
ORIGIN      
        1 mskskvdnqf ysvevgdstf tvlkryqnlk pigsgaqgiv caaydavldr nvaikklsrp
       61 fqnqthakra yrelvlmkcv nhkniislln vftpqktlee fqdvylvmel mdanlcqviq
      121 meldhermsy llyqmlcgik hlhsagiihr dlkpsnivvk sdctlkildf glartagtsf
      181 mmtpyvvtry yrapevilgm gykendidqw nkvieqlgtp cpefmkklqp tvrnyvenrp
      241 kyagltfpkl fpdslfpads ehnklkasqa rdllskmlvi dpakrisvdd alqhpyinvw
      301 ydpaeveapp pqiydkqlde rehtieewke liykevmnse ektkngvvkg qpspsaqvqq
//
LOCUS       NP_573474               1050 aa            linear   ROD 09-OCT-2023
DEFINITION  toll-like receptor 7 isoform a precursor [Mus musculus].
ACCESSION   NP_573474 XP_918297
VERSION     NP_573474.1
DBSOURCE    REFSEQ: accession NM_133211.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1050)
  AUTHORS   Huang Y, Liu D, Chen M, Xu S, Peng Q, Zhu Y, Long J, Liu T, Deng Z,
            Xie H, Li J, Liu F and Xiao W.
  TITLE     TLR7 promotes skin inflammation via activating NFkappaB-mTORC1 axis
            in rosacea
  JOURNAL   PeerJ 11, e15976 (2023)
   PUBMED   37780385
  REMARK    GeneRIF: TLR7 promotes skin inflammation via activating
            NFkappaB-mTORC1 axis in rosacea.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1050)
  AUTHORS   Miles MA, Liong S, Liong F, Coward-Smith M, Trollope GS, Oseghale
            O, Erlich JR, Brooks RD, Logan JM, Hickey S, Wang H, Bozinovski S,
            O'Leary JJ, Brooks DA and Selemidis S.
  TITLE     TLR7 promotes chronic airway disease in RSV-infected mice
  JOURNAL   Front Immunol 14, 1240552 (2023)
   PUBMED   37795093
  REMARK    GeneRIF: TLR7 promotes chronic airway disease in RSV-infected mice.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1050)
  AUTHORS   Cosgrove HA, Gingras S, Kim M, Bastacky S, Tilstra JS and Shlomchik
            MJ.
  TITLE     B cell-intrinsic TLR7 expression drives severe lupus in
            TLR9-deficient mice
  JOURNAL   JCI Insight 8 (16), e172219 (2023)
   PUBMED   37606042
  REMARK    GeneRIF: B cell-intrinsic TLR7 expression drives severe lupus in
            TLR9-deficient mice.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1050)
  AUTHORS   Kim J, Ha S, Son M, Kim D, Kim MJ, Kim B, Kim D, Chung HY and Chung
            KW.
  TITLE     TLR7 activation by miR-21 promotes renal fibrosis by activating the
            pro-inflammatory signaling pathway in tubule epithelial cells
  JOURNAL   Cell Commun Signal 21 (1), 215 (2023)
   PUBMED   37596656
  REMARK    GeneRIF: TLR7 activation by miR-21 promotes renal fibrosis by
            activating the pro-inflammatory signaling pathway in tubule
            epithelial cells.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1050)
  AUTHORS   Jackson WD, Giacomassi C, Ward S, Owen A, Luis TC, Spear S,
            Woollard KJ, Johansson C, Strid J and Botto M.
  TITLE     TLR7 activation at epithelial barriers promotes emergency
            myelopoiesis and lung antiviral immunity
  JOURNAL   Elife 12, e85647 (2023)
   PUBMED   37566453
  REMARK    GeneRIF: TLR7 activation at epithelial barriers promotes emergency
            myelopoiesis and lung antiviral immunity.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1050)
  AUTHORS   Heil F, Hemmi H, Hochrein H, Ampenberger F, Kirschning C, Akira S,
            Lipford G, Wagner H and Bauer S.
  TITLE     Species-specific recognition of single-stranded RNA via toll-like
            receptor 7 and 8
  JOURNAL   Science 303 (5663), 1526-1529 (2004)
   PUBMED   14976262
  REMARK    GeneRIF: mediates species-specific recognition of GU-rich
            single-stranded RNA (ssRNA); data suggest that ssRNA represents a
            physiological ligand for TLR7
REFERENCE   7  (residues 1 to 1050)
  AUTHORS   Diebold SS, Kaisho T, Hemmi H, Akira S and Reis e Sousa C.
  TITLE     Innate antiviral responses by means of TLR7-mediated recognition of
            single-stranded RNA
  JOURNAL   Science 303 (5663), 1529-1531 (2004)
   PUBMED   14976261
  REMARK    GeneRIF: results identify ssRNA as a ligand for TLR7 and suggest
            that cells of the innate immune system sense endosomal ssRNA to
            detect infection by RNA viruses
REFERENCE   8  (residues 1 to 1050)
  AUTHORS   Pinhal-Enfield G, Ramanathan M, Hasko G, Vogel SN, Salzman AL,
            Boons GJ and Leibovich SJ.
  TITLE     An angiogenic switch in macrophages involving synergy between
            Toll-like receptors 2, 4, 7, and 9 and adenosine A(2A) receptors
  JOURNAL   Am J Pathol 163 (2), 711-721 (2003)
   PUBMED   12875990
  REMARK    GeneRIF: Results suggest novel signaling pathway in murine
            macrophages involving synergy between toll-like receptors 2, 4, 7,
            and 9 and adenosine A(2A)receptors, that up-regulates VEGF and
            down-regulates TNFalpha expression, thus acting as an angiogenic
            switch.
REFERENCE   9  (residues 1 to 1050)
  AUTHORS   Jurk,M., Heil,F., Vollmer,J., Schetter,C., Krieg,A.M., Wagner,H.,
            Lipford,G. and Bauer,S.
  TITLE     Human TLR7 or TLR8 independently confer responsiveness to the
            antiviral compound R-848
  JOURNAL   Nat Immunol 3 (6), 499 (2002)
   PUBMED   12032557
REFERENCE   10 (residues 1 to 1050)
  AUTHORS   Hemmi H, Kaisho T, Takeuchi O, Sato S, Sanjo H, Hoshino K, Horiuchi
            T, Tomizawa H, Takeda K and Akira S.
  TITLE     Small anti-viral compounds activate immune cells via the TLR7
            MyD88-dependent signaling pathway
  JOURNAL   Nat Immunol 3 (2), 196-200 (2002)
   PUBMED   11812998
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL731735.14, AK036549.1 and BY543663.1.
            
            On Dec 7, 2005 this sequence version replaced XP_918297.1.
            
            Transcript Variant: This variant (3) lacks two alternate exons in
            the 5' region and initiates translation from an alternate upstream
            start codon, compared to variant 1. Variants 1, 2, 3, and 4 encode
            the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036549.1, AF334942.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1050
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 78.31 cM"
     Protein         1..1050
                     /product="toll-like receptor 7 isoform a precursor"
                     /note="Toll like receptor 7"
                     /calculated_mol_wt=118668
     sig_peptide     1..26
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
                     /calculated_mol_wt=3187
     Region          <32..>243
                     /region_name="PRK15370"
                     /note="type III secretion system effector E3 ubiquitin
                     transferase SlrP"
                     /db_xref="CDD:185268"
     Region          42..64
                     /region_name="LRR 1"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          48..69
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          65..87
                     /region_name="LRR 2"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Site            66
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Site            69
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Region          70..90
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          89..111
                     /region_name="LRR 3"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          91..128
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          126..149
                     /region_name="LRR 4"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          129..152
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          151..170
                     /region_name="LRR 5"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Site            167
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Region          171..195
                     /region_name="LRR 6"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          174..>786
                     /region_name="PLN00113"
                     /note="leucine-rich repeat receptor-like protein kinase;
                     Provisional"
                     /db_xref="CDD:215061"
     Region          174..205
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            190
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Region          203..226
                     /region_name="LRR 7"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          206..226
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            215
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Region          227..250
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          228..247
                     /region_name="LRR 8"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          248..273
                     /region_name="LRR 9"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          251..291
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          275..289
                     /region_name="LRR 10"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          290..312
                     /region_name="LRR 11"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          292..315
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          314..337
                     /region_name="LRR 12"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          316..341
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          339..364
                     /region_name="LRR 13"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          342..398
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          369..392
                     /region_name="LRR 14"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Site            387
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Region          396..419
                     /region_name="LRR 15"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          399..422
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          421..443
                     /region_name="LRR 16"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          493..516
                     /region_name="LRR 17"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          497..519
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          517..542
                     /region_name="LRR 18"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          520..544
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            524
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Site            535
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Region          543..565
                     /region_name="LRR 19"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          545..568
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          567..589
                     /region_name="LRR 20"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          569..598
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            591
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Region          596..619
                     /region_name="LRR 21"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          599..621
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          620..645
                     /region_name="LRR 22"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          622..652
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          650..673
                     /region_name="LRR 23"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          653..677
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          675..698
                     /region_name="LRR 24"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          678..701
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            680
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Region          699..722
                     /region_name="LRR 25"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          702..725
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            721
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Region          724..746
                     /region_name="LRR 26"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          747..770
                     /region_name="LRR 27"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          750..775
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          754..>838
                     /region_name="PCC"
                     /note="polycystin cation channel protein; TIGR00864"
                     /db_xref="CDD:188093"
     Region          773..796
                     /region_name="LRR 28"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Site            800
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P58681.1)"
     Site            838..858
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P58681.1)"
     Region          891..1036
                     /region_name="TIR"
                     /note="Toll - interleukin 1 - resistance; smart00255"
                     /db_xref="CDD:214587"
     CDS             1..1050
                     /gene="Tlr7"
                     /coded_by="NM_133211.4:232..3384"
                     /note="isoform a precursor is encoded by transcript
                     variant 3"
                     /db_xref="CCDS:CCDS30531.1"
                     /db_xref="GeneID:170743"
                     /db_xref="MGI:MGI:2176882"
ORIGIN      
        1 mvfsmwtrkr qiliflnmll vsrvfgfrwf pktlpcevkv nipeahvivd ctdkhlteip
       61 egiptnttnl tltinhipsi spdsfrrlnh leeidlrcnc vpvllgskan vctkrlqirp
      121 gsfsglsdlk alyldgnqll eipqdlpssl hllsleanni fsitkenlte lvnietlylg
      181 qncyyrnpcn vsysiekdaf lvmrnlkvls lkdnnvtavp ttlppnllel ylynniikki
      241 qendfnnlne lqvldlsgnc prcynvpypc tpcennsplq ihdnafnslt elkvlrlhsn
      301 slqhvpptwf knmrnlqeld lsqnylarei eeakflhflp nlveldfsfn yelqvyhasi
      361 tlphslssle nlkilrvkgy vfkelknssl svlhklprle vldlgtnfik iadlnifkhf
      421 enlklidlsv nkispseesr evgfcpnaqt svdrhgpqvl ealhyfryde yarscrfknk
      481 eppsflplna dchiygqtld lsrnniffik psdfqhlsfl kclnlsgnti gqtlngselw
      541 plrelryldf snnrldllys tafeelqsle vldlssnshy fqaegithml nftkklrlld
      601 klmmndndis tsasrtmesd slrilefrgn hldvlwragd nryldffknl fnlevldisr
      661 nslnslppev fegmppnlkn lslaknglks ffwdrlqllk hleildlshn qltkvperla
      721 ncskslttli lkhnqirqlt kyfledalql ryldissnki qviqktsfpe nvlnnlemlv
      781 lhhnrflcnc davwfvwwvn htdvtipyla tdvtcvgpga hkgqsvisld lytceldltn
      841 lilfsvsiss vlflmvvmtt shlffwdmwy iyyfwkakik gyqhlqsmes cydafivydt
      901 knsavtewvl qelvakledp rekhfnlcle erdwlpgqpv lenlsqsiql skktvfvmtq
      961 kyaktesfkm afylshqrll dekvdviili flekplqksk flqlrkrlcr ssvlewpanp
     1021 qahpyfwqcl knalttdnhv aysqmfketv
//
LOCUS       NP_001349266             362 aa            linear   ROD 09-OCT-2023
DEFINITION  CUGBP Elav-like family member 4 isoform 55 [Mus musculus].
ACCESSION   NP_001349266 XP_017173291
VERSION     NP_001349266.1
DBSOURCE    REFSEQ: accession NM_001362337.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 362)
  AUTHORS   Salamon I, Park Y, Miskic T, Kopic J, Matteson P, Page NF, Roque A,
            McAuliffe GW, Favate J, Garcia-Forn M, Shah P, Judas M, Millonig
            JH, Kostovic I, De Rubeis S, Hart RP, Krsnik Z and Rasin MR.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    GeneRIF: Celf4 controls mRNA translation underlying synaptic
            development in the prenatal mammalian neocortex.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 362)
  AUTHORS   Shen Y, Zhang C, Xiao K, Liu D and Xie G.
  TITLE     CELF4 regulates spine formation and depression-like behaviors of
            mice
  JOURNAL   Biochem Biophys Res Commun 605, 39-44 (2022)
   PUBMED   35306363
  REMARK    GeneRIF: CELF4 regulates spine formation and depression-like
            behaviors of mice.
REFERENCE   3  (residues 1 to 362)
  AUTHORS   Moreau MX, Saillour Y, Cwetsch AW, Pierani A and Causeret F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   4  (residues 1 to 362)
  AUTHORS   Li C, Li X, Bi Z, Sugino K, Wang G, Zhu T and Liu Z.
  TITLE     Comprehensive transcriptome analysis of cochlear spiral ganglion
            neurons at multiple ages
  JOURNAL   Elife 9, e50491 (2020)
   PUBMED   31913118
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 362)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 362)
  AUTHORS   Ladd AN, Taffet G, Hartley C, Kearney DL and Cooper TA.
  TITLE     Cardiac tissue-specific repression of CELF activity disrupts
            alternative splicing and causes cardiomyopathy
  JOURNAL   Mol Cell Biol 25 (14), 6267-6278 (2005)
   PUBMED   15988035
  REMARK    GeneRIF: CELF protein activity is required for normal alternative
            splicing in the heart in vivo and normal CELF-mediated alternative
            splicing regulation is in turn required for normal cardiac
            function.
REFERENCE   7  (residues 1 to 362)
  AUTHORS   Meins M, Schlickum S, Wilhelm C, Missbach J, Yadav S, Glaser B,
            Grzmil M, Burfeind P and Laccone F.
  TITLE     Identification and characterization of murine Brunol4, a new member
            of the elav/bruno family
  JOURNAL   Cytogenet Genome Res 97 (3-4), 254-260 (2002)
   PUBMED   12438720
  REMARK    GeneRIF: cloning and characterization
REFERENCE   8  (residues 1 to 362)
  AUTHORS   Ladd AN, Charlet N and Cooper TA.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   9  (residues 1 to 362)
  AUTHORS   Good PJ, Chen Q, Warner SJ and Herring DC.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
REFERENCE   10 (residues 1 to 362)
  AUTHORS   Yulug IG, Egan SE, See CG and Fisher EM.
  TITLE     Mapping GRB2, a signal transduction gene in the human and the mouse
  JOURNAL   Genomics 22 (2), 313-318 (1994)
   PUBMED   7806216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121094.8 and AC144938.3.
            
            On Apr 12, 2018 this sequence version replaced XP_017173291.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660819.179292.1,
                                           SRR1660817.323477.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..362
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 13.92 cM"
     Protein         1..362
                     /product="CUGBP Elav-like family member 4 isoform 55"
                     /note="CUG-BP- and ETR-3-like factor 4; bruno-like protein
                     4; RNA-binding protein BRUNOL-4; bruno-like 4, RNA binding
                     protein"
                     /calculated_mol_wt=38364
     Region          27..107
                     /region_name="RRM2_CELF3_4_5_6"
                     /note="RNA recognition motif 2 (RRM2) found in CUGBP
                     Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and
                     similar proteins; cd12635"
                     /db_xref="CDD:410043"
     Site            order(29,31,33..34,37,56,58,60,68..70,72,102,104)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:410043"
     Region          <30..254
                     /region_name="PABP-1234"
                     /note="polyadenylate binding protein, human types 1, 2, 3,
                     4 family; TIGR01628"
                     /db_xref="CDD:130689"
     Region          293..351
                     /region_name="RRM_SF"
                     /note="RNA recognition motif (RRM) superfamily; cl17169"
                     /db_xref="CDD:450164"
     CDS             1..362
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /coded_by="NM_001362337.1:214..1302"
                     /note="isoform 55 is encoded by transcript variant 56"
                     /db_xref="GeneID:108013"
                     /db_xref="MGI:MGI:1932407"
ORIGIN      
        1 mnrpiqvkpa dsesrggssc lrqppshrkl fvgmlnkqqs eddvrrlfea fgnieectil
       61 rgpdgnskgc afvkysshae aqaainalhg sqtmpgasss lvvkfadtdk ertmrrmqqm
      121 agqmgmfnpm aipfgaygay aqalmqqqaa lmasvaqggy lnpmaafaaa qmqqmaalnm
      181 nglaaapmtp tsggstppgi tapavpsips pigvngftgl ppqangqpaa eavfangihp
      241 ypaqsptaad plqqayagvq qyagpaaypa aygqisqafp qpppmipqqq regpegcnll
      301 iyhlpqefgd aelmqmflpf gfvsfdnpas aqtaiqamng fqigmkrlkv qlkrpkdanr
      361 py
//
LOCUS       NP_001017959             415 aa            linear   ROD 09-OCT-2023
DEFINITION  lysosome-associated membrane glycoprotein 2 isoform 1 precursor
            [Mus musculus].
ACCESSION   NP_001017959
VERSION     NP_001017959.1
DBSOURCE    REFSEQ: accession NM_001017959.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 415)
  AUTHORS   Liu D, Xing R, Zhang Q, Tian X, Qi Y, Song H, Liu Y, Yu H, Zhang X,
            Jing Q, Yan C and Han Y.
  TITLE     The CREG1-FBXO27-LAMP2 axis alleviates diabetic cardiomyopathy by
            promoting autophagy in cardiomyocytes
  JOURNAL   Exp Mol Med 55 (9), 2025-2038 (2023)
   PUBMED   37658156
  REMARK    GeneRIF: The CREG1-FBXO27-LAMP2 axis alleviates diabetic
            cardiomyopathy by promoting autophagy in cardiomyocytes.
REFERENCE   2  (residues 1 to 415)
  AUTHORS   Wang Y, Hang K, Ying L, Wu J, Wu X, Zhang W, Li L, Wang Z, Bai J,
            Gao X, Xue D and Pan Z.
  TITLE     LAMP2A regulates the balance of mesenchymal stem cell
            adipo-osteogenesis via the Wnt/beta-catenin/GSK3beta signaling
            pathway
  JOURNAL   J Mol Med (Berl) 101 (7), 783-799 (2023)
   PUBMED   37162558
  REMARK    GeneRIF: LAMP2A regulates the balance of mesenchymal stem cell
            adipo-osteogenesis via the Wnt/beta-catenin/GSK3beta signaling
            pathway.
REFERENCE   3  (residues 1 to 415)
  AUTHORS   Zhang KK, Zhang P, Kodur A, Erturk I, Burns CM, Kenyon C, Miller RA
            and Endicott SJ.
  TITLE     LAMP2A, and other chaperone-mediated autophagy related proteins, do
            not decline with age in genetically heterogeneous UM-HET3 mice
  JOURNAL   Aging (Albany NY) 15 (11), 4685-4698 (2023)
   PUBMED   37315291
  REMARK    GeneRIF: LAMP2A, and other chaperone-mediated autophagy related
            proteins, do not decline with age in genetically heterogeneous
            UM-HET3 mice.
REFERENCE   4  (residues 1 to 415)
  AUTHORS   Maglica M, Kelam N, Haque E, Perutina I, Racetin A, Filipovic N,
            Katsuyama Y and Vukojevic K.
  TITLE     Immunoexpression Pattern of Autophagy Markers in Developing and
            Postnatal Kidneys of Dab1-/-(yotari) Mice
  JOURNAL   Biomolecules 13 (3), 402 (2023)
   PUBMED   36979337
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 415)
  AUTHORS   Sutton KA and Wilkinson MF.
  TITLE     The rapidly evolving Pem homeobox gene and Agtr2, Ant2, and Lamp2
            are closely linked in the proximal region of the mouse X chromosome
  JOURNAL   Genomics 45 (2), 447-450 (1997)
   PUBMED   9344676
REFERENCE   6  (residues 1 to 415)
  AUTHORS   Cella N, Cornejo-Uribe RR, Montes GS, Hynes NE and Chammas R.
  TITLE     The lysosomal-associated membrane protein LAMP-1 is a novel
            differentiation marker for HC11 mouse mammary epithelial cells
  JOURNAL   Differentiation 61 (2), 113-120 (1996)
   PUBMED   8983177
REFERENCE   7  (residues 1 to 415)
  AUTHORS   Gough NR, Hatem CL and Fambrough DM.
  TITLE     The family of LAMP-2 proteins arises by alternative splicing from a
            single gene: characterization of the avian LAMP-2 gene and
            identification of mammalian homologs of LAMP-2b and LAMP-2c
  JOURNAL   DNA Cell Biol 14 (10), 863-867 (1995)
   PUBMED   7546292
REFERENCE   8  (residues 1 to 415)
  AUTHORS   Dardik A, Smith RM and Schultz RM.
  TITLE     Colocalization of transforming growth factor-alpha and a functional
            epidermal growth factor receptor (EGFR) to the inner cell mass and
            preferential localization of the EGFR on the basolateral surface of
            the trophectoderm in the mouse blastocyst
  JOURNAL   Dev Biol 154 (2), 396-409 (1992)
   PUBMED   1426645
REFERENCE   9  (residues 1 to 415)
  AUTHORS   Granger BL, Green SA, Gabel CA, Howe CL, Mellman I and Helenius A.
  TITLE     Characterization and cloning of lgp110, a lysosomal membrane
            glycoprotein from mouse and rat cells
  JOURNAL   J Biol Chem 265 (20), 12036-12043 (1990)
   PUBMED   2142158
REFERENCE   10 (residues 1 to 415)
  AUTHORS   Cha Y, Holland SM and August JT.
  TITLE     The cDNA sequence of mouse LAMP-2. Evidence for two classes of
            lysosomal membrane glycoproteins
  JOURNAL   J Biol Chem 265 (9), 5008-5013 (1990)
   PUBMED   2318880
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK163933.1, AK159272.1 and AL513356.8.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK159272.1, AK159731.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..415
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 22.67 cM"
     Protein         1..415
                     /product="lysosome-associated membrane glycoprotein 2
                     isoform 1 precursor"
                     /note="lysosome-associated membrane glycoprotein 2; CD107
                     antigen-like family member B; lysosomal membrane
                     glycoprotein type B; lysosomal membrane glycoprotein 2"
                     /calculated_mol_wt=43065
     sig_peptide     1..25
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=2634
     Region          26..188
                     /region_name="First lumenal domain"
                     /note="propagated from UniProtKB/Swiss-Prot (P17047.2)"
     Site            29
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P17047.2)"
     Site            45
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P17047.2)"
     Site            54
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P17047.2)"
     Site            57
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P17047.2)"
     Site            97
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P17047.2)"
     Site            115
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P17047.2)"
     Site            175
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P17047.2)"
     Region          189..233
                     /region_name="Hinge"
                     /note="propagated from UniProtKB/Swiss-Prot (P17047.2)"
     Region          202..227
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P17047.2)"
     Region          225..363
                     /region_name="Lamp"
                     /note="Lysosome-associated membrane glycoprotein (Lamp);
                     pfam01299"
                     /db_xref="CDD:426189"
     Site            227
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P17047.2)"
     Region          234..379
                     /region_name="Second lumenal domain"
                     /note="propagated from UniProtKB/Swiss-Prot (P17047.2)"
     Site            234
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P17047.2)"
     Site            247
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P17047.2)"
     Site            265
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P17047.2)"
     Site            280
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P17047.2)"
     Site            312
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P17047.2)"
     Site            317
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P17047.2)"
     Site            322
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P17047.2)"
     Site            361
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P17047.2)"
     Site            380..404
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P17047.2)"
     Region          406..409
                     /region_name="Important for binding and subsequent
                     lysosomal degradation of target proteins.
                     /evidence=ECO:0000250|UniProtKB:P13473"
                     /note="propagated from UniProtKB/Swiss-Prot (P17047.2)"
     CDS             1..415
                     /gene="Lamp2"
                     /gene_synonym="CD107b; Lamp II; Lamp-2; Lamp-2a; Lamp-2b;
                     Lamp-2c; LGP-B; Mac3"
                     /coded_by="NM_001017959.2:158..1405"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS30092.1"
                     /db_xref="GeneID:16784"
                     /db_xref="MGI:MGI:96748"
ORIGIN      
        1 mclspvkgak liliflflga vqsnalivnl tdskgtclya ewemnftity ettnqtnkti
       61 tiavpdkath dgsscgddrn sakimiqfgf avswavnftk eashysihdi vlsyntsdst
      121 vfpgavakgv htvknpenfk vpldvifkcn svltynltpv vqkywgihlq afvqngtvsk
      181 neqvceedqt pttvapiiht tapsttttlt ptstptptpt ptptvgnysi rngnttclla
      241 tmglqlnite ekvpfifnin pattnftgsc qpqsaqlrln nsqikyldfi favknekrfy
      301 lkevnvymyl angsafnisn knlsfwdapl gssymcnkeq vlsvsrafqi ntfnlkvqpf
      361 nvtkgqysta qdcsadednf lvpiavgaal ggvlilvlla yfiglkrhht gyeqf
//
LOCUS       NP_001397158             491 aa            linear   ROD 09-OCT-2023
DEFINITION  nuclear respiratory factor 1 isoform h [Mus musculus].
ACCESSION   NP_001397158 XP_006505071
VERSION     NP_001397158.1
DBSOURCE    REFSEQ: accession NM_001410229.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 491)
  AUTHORS   Cheng C, Tian Y, Yang R, Guo W, Xiao K, Zhang F, Tian J, Deng Z,
            Yang W, Yang H and Zhou Z.
  TITLE     miR-5581 Contributes to Osteoarthritis by Targeting NRF1 to Disturb
            the Proliferation and Functions of Chondrocytes
  JOURNAL   Am J Pathol 193 (9), 1234-1247 (2023)
   PUBMED   37611970
  REMARK    GeneRIF: miR-5581 Contributes to Osteoarthritis by Targeting NRF1
            to Disturb the Proliferation and Functions of Chondrocytes.
REFERENCE   2  (residues 1 to 491)
  AUTHORS   Meng Z, Liang B, Wu Y, Liu C, Wang H, Du Y, Gan L, Gao E, Lau WB,
            Christopher TA, Lopez BL, Koch WJ, Ma X, Zhao F, Wang Y and Zhao J.
  TITLE     Hypoadiponectinemia-induced upregulation of microRNA449b
            downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury
            in diabetic mice
  JOURNAL   J Mol Cell Cardiol 182, 1-14 (2023)
   PUBMED   37437402
  REMARK    GeneRIF: Hypoadiponectinemia-induced upregulation of microRNA449b
            downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury
            in diabetic mice.
REFERENCE   3  (residues 1 to 491)
  AUTHORS   Zhao T, Zhang J, Lei H, Meng Y, Cheng H, Zhao Y, Geng G, Mu C, Chen
            L, Liu Q, Luo Q, Zhang C, Long Y, Su J, Wang Y, Li Z, Sun J, Chen
            G, Li Y, Liao X, Shang Y, Hu G, Chen Q and Zhu Y.
  TITLE     NRF1-mediated mitochondrial biogenesis antagonizes innate antiviral
            immunity
  JOURNAL   EMBO J 42 (16), e113258 (2023)
   PUBMED   37409632
  REMARK    GeneRIF: NRF1-mediated mitochondrial biogenesis antagonizes innate
            antiviral immunity.
REFERENCE   4  (residues 1 to 491)
  AUTHORS   Akl MG, Baccetto R, Stebbings BM, Li L and Widenmaier SB.
  TITLE     Euglycemia is affected by stress defense factor hepatocyte NRF1,
            but not NRF2
  JOURNAL   Biochem Biophys Res Commun 668, 96-103 (2023)
   PUBMED   37245295
  REMARK    GeneRIF: Euglycemia is affected by stress defense factor hepatocyte
            NRF1, but not NRF2.
REFERENCE   5  (residues 1 to 491)
  AUTHORS   Akl MG, Li L, Baccetto R, Phanse S, Zhang Q, Trites MJ, McDonald S,
            Aoki H, Babu M and Widenmaier SB.
  TITLE     Complementary gene regulation by NRF1 and NRF2 protects against
            hepatic cholesterol overload
  JOURNAL   Cell Rep 42 (4), 112399 (2023)
   PUBMED   37060561
  REMARK    GeneRIF: Complementary gene regulation by NRF1 and NRF2 protects
            against hepatic cholesterol overload.
            Erratum:[Cell Rep. 2023 Jul 25;42(7):112872. PMID: 37454293]
REFERENCE   6  (residues 1 to 491)
  AUTHORS   Carmona MC, Iglesias R, Obregon MJ, Darlington GJ, Villarroya F and
            Giralt M.
  TITLE     Mitochondrial biogenesis and thyroid status maturation in brown fat
            require CCAAT/enhancer-binding protein alpha
  JOURNAL   J Biol Chem 277 (24), 21489-21498 (2002)
   PUBMED   11940593
REFERENCE   7  (residues 1 to 491)
  AUTHORS   Huo L and Scarpulla RC.
  TITLE     Mitochondrial DNA instability and peri-implantation lethality
            associated with targeted disruption of nuclear respiratory factor 1
            in mice
  JOURNAL   Mol Cell Biol 21 (2), 644-654 (2001)
   PUBMED   11134350
REFERENCE   8  (residues 1 to 491)
  AUTHORS   Schaefer L, Engman H and Miller JB.
  TITLE     Coding sequence, chromosomal localization, and expression pattern
            of Nrf1: the mouse homolog of Drosophila erect wing
  JOURNAL   Mamm Genome 11 (2), 104-110 (2000)
   PUBMED   10656923
REFERENCE   9  (residues 1 to 491)
  AUTHORS   Huo L and Scarpulla RC.
  TITLE     Multiple 5'-untranslated exons in the nuclear respiratory factor 1
            gene span 47 kb and contribute to transcript heterogeneity and
            translational efficiency
  JOURNAL   Gene 233 (1-2), 213-224 (1999)
   PUBMED   10375638
REFERENCE   10 (residues 1 to 491)
  AUTHORS   Virbasius CA, Virbasius JV and Scarpulla RC.
  TITLE     NRF-1, an activator involved in nuclear-mitochondrial interactions,
            utilizes a new DNA-binding domain conserved in a family of
            developmental regulators
  JOURNAL   Genes Dev 7 (12A), 2431-2445 (1993)
   PUBMED   8253388
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134897.4 and AC153632.2.
            
            On Aug 1, 2022 this sequence version replaced XP_006505071.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784645.841229.1,
                                           SRR17253013.2097426.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 12.47 cM"
     Protein         1..491
                     /product="nuclear respiratory factor 1 isoform h"
                     /note="NRF-1; alpha-pal; alpha palindromic-binding
                     protein"
                     /calculated_mol_wt=52353
     Region          87..295
                     /region_name="Nrf1_DNA-bind"
                     /note="NLS-binding and DNA-binding and dimerization
                     domains of Nrf1; pfam10491"
                     /db_xref="CDD:402218"
     CDS             1..491
                     /gene="Nrf1"
                     /gene_synonym="D6Ertd415e"
                     /coded_by="NM_001410229.1:274..1749"
                     /note="isoform h is encoded by transcript variant 19"
                     /db_xref="GeneID:18181"
                     /db_xref="MGI:MGI:1332235"
ORIGIN      
        1 meehgvtqte hmatieahav aqqvqqvhva tytehsmlsa dedspssped tsyddsdiln
       61 staadevtah laaavlgikp rashilgpvg maaaaavatg kkrkrphvfe snpsirkrqq
      121 trllrklrat ldeyttrvgq qaivlcisps kpnpvfkvfg aaplenvvrk yksmiledle
      181 salaehapap qevnselppl tidgipvsvd kmtqaqlraf ipemlkystg rgkpgwgkes
      241 ckpiwwpedi pwanvrsdvr teeqkqrvsw tqalrtivkn cykqhgredl lyafedqqtq
      301 tqattthsia hlvpsqtvvq tfsnpdgtvs liqvgtgatv atladaselp ttvtvaqvny
      361 savadgeveq nwatlqggem tiqttqasea tqavaslaea avaasqemqq gatvtmalns
      421 eaaahavatl aeatlqgggq ivlsgetaaa vgaltgvqda nglfmadcgg ykwilarrlq
      481 vgsslgregs s
//
LOCUS       NP_032706                789 aa            linear   ROD 09-OCT-2023
DEFINITION  protein enabled homolog isoform 2 [Mus musculus].
ACCESSION   NP_032706
VERSION     NP_032706.2
DBSOURCE    REFSEQ: accession NM_008680.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 789)
  AUTHORS   Yun S, Cha SS and Kim JH.
  TITLE     DJ-1 promotes cell migration by interacting with Mena, the
            mammalian homolog of Drosophila enabled
  JOURNAL   Adv Biol Regul 88, 100943 (2023)
   PUBMED   36542983
  REMARK    GeneRIF: DJ-1 promotes cell migration by interacting with Mena, the
            mammalian homolog of Drosophila enabled.
REFERENCE   2  (residues 1 to 789)
  AUTHORS   Wang W, Taufalele PV, Millet M, Homsy K, Smart K, Berestesky ED,
            Schunk CT, Rowe MM, Bordeleau F and Reinhart-King CA.
  TITLE     Matrix stiffness regulates tumor cell intravasation through
            expression and ESRP1-mediated alternative splicing of MENA
  JOURNAL   Cell Rep 42 (4), 112338 (2023)
   PUBMED   37027295
  REMARK    GeneRIF: Matrix stiffness regulates tumor cell intravasation
            through expression and ESRP1-mediated alternative splicing of MENA.
REFERENCE   3  (residues 1 to 789)
  AUTHORS   Borriello L, Coste A, Traub B, Sharma VP, Karagiannis GS, Lin Y,
            Wang Y, Ye X, Duran CL, Chen X, Friedman M, Sosa MS, Sun D, Dalla
            E, Singh DK, Oktay MH, Aguirre-Ghiso JA, Condeelis JS and Entenberg
            D.
  TITLE     Primary tumor associated macrophages activate programs of invasion
            and dormancy in disseminating tumor cells
  JOURNAL   Nat Commun 13 (1), 626 (2022)
   PUBMED   35110548
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 789)
  AUTHORS   Hooper JE, Jones KL, Smith FJ, Williams T and Li H.
  TITLE     An Alternative Splicing Program for Mouse Craniofacial Development
  JOURNAL   Front Physiol 11, 1099 (2020)
   PUBMED   33013468
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 789)
  AUTHORS   Lee S, Sears MJ, Zhang Z, Li H, Salhab I, Krebs P, Xing Y, Nah HD,
            Williams T and Carstens RP.
  TITLE     Cleft lip and cleft palate in Esrp1 knockout mice is associated
            with alterations in epithelial-mesenchymal crosstalk
  JOURNAL   Development 147 (21) (2020)
   PUBMED   32253237
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 789)
  AUTHORS   Ermekova KS, Zambrano N, Linn H, Minopoli G, Gertler F, Russo T and
            Sudol M.
  TITLE     The WW domain of neural protein FE65 interacts with proline-rich
            motifs in Mena, the mammalian homolog of Drosophila enabled
  JOURNAL   J Biol Chem 272 (52), 32869-32877 (1997)
   PUBMED   9407065
REFERENCE   7  (residues 1 to 789)
  AUTHORS   Bedford MT, Chan DC and Leder P.
  TITLE     FBP WW domains and the Abl SH3 domain bind to a specific class of
            proline-rich ligands
  JOURNAL   EMBO J 16 (9), 2376-2383 (1997)
   PUBMED   9171351
REFERENCE   8  (residues 1 to 789)
  AUTHORS   Yamabhai M and Kay BK.
  TITLE     Examining the specificity of Src homology 3 domain--ligand
            interactions with alkaline phosphatase fusion proteins
  JOURNAL   Anal Biochem 247 (1), 143-151 (1997)
   PUBMED   9126384
REFERENCE   9  (residues 1 to 789)
  AUTHORS   Gertler FB, Niebuhr K, Reinhard M, Wehland J and Soriano P.
  TITLE     Mena, a relative of VASP and Drosophila Enabled, is implicated in
            the control of microfilament dynamics
  JOURNAL   Cell 87 (2), 227-239 (1996)
   PUBMED   8861907
REFERENCE   10 (residues 1 to 789)
  AUTHORS   Sazuka T, Tomooka Y, Kathju S, Ikawa Y, Noda M and Kumar S.
  TITLE     Identification of a developmentally regulated gene in the mouse
            central nervous system which encodes a novel proline rich protein
  JOURNAL   Biochim Biophys Acta 1132 (3), 240-248 (1992)
   PUBMED   1420303
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122204.3 and AC165229.7.
            
            On Mar 20, 2007 this sequence version replaced NP_032706.1.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U72522.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164141 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..789
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 84.93 cM"
     Protein         1..789
                     /product="protein enabled homolog isoform 2"
                     /note="protein enabled homolog; NPC derived proline rich
                     protein 1"
                     /calculated_mol_wt=84376
     Region          5..112
                     /region_name="EVH1_Ena_VASP-like"
                     /note="Enabled/VASP family EVH1 domain; cd01207"
                     /db_xref="CDD:269918"
     Site            order(16,23,69,71,77,79,81)
                     /site_type="other"
                     /note="proline-rich peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:269918"
     Region          <306..526
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          604..630
                     /region_name="WH2_hVASP-like"
                     /note="Wiskott-Aldrich syndrome protein (WASP)-homology
                     domain 2 (WH2) of human Vasodilator-stimulated
                     phosphoprotein and related proteins; cd22185"
                     /db_xref="CDD:409225"
     Site            order(611..612,614..615,618,620..624)
                     /site_type="other"
                     /note="actin-binding motif [polypeptide binding]"
                     /db_xref="CDD:409225"
     Region          620..623
                     /region_name="actin-binding sequence"
                     /note="actin-binding sequence [structural motif]"
                     /db_xref="CDD:409225"
     Region          750..785
                     /region_name="VASP_tetra"
                     /note="VASP tetramerisation domain; pfam08776"
                     /db_xref="CDD:430211"
     CDS             1..789
                     /gene="Enah"
                     /gene_synonym="Mena; NDPP-1; Ndpp1; WBP8"
                     /coded_by="NM_008680.4:449..2818"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS48474.1"
                     /db_xref="GeneID:13800"
                     /db_xref="MGI:MGI:108360"
ORIGIN      
        1 mseqsicqar aavmvyddan kkwvpaggst gfsrvhiyhh tgnntfrvvg rkiqdhqvvi
       61 ncaipkglky nqatqtfhqw rdarqvygln fgskedanvf asammhalev lnsqeavfyl
      121 gptlprqnsq lpaqvqngps qeeleiqrrq lqeqqrqkel erermererl ererlererl
      181 ererleqeql erqrqerehv erlererler lererqerer erleqlereq vewererrms
      241 naapssdssl ssaplpeyss cqppsappps yakvisapvs datpdyavvt alpptstppt
      301 pplrhaatrf atslgsafhp vlphyatvpr plnknsrpss pvntpssqpp aakscawpts
      361 nfsplppspp imissppgka tgprpvlpvc vsspvpqmpp sptapngsld svtypvsppp
      421 tsgpaapppp pppppppppp ppplpppplp plaslshcgs qaspppgtpl astpsskpsv
      481 lpspsaaapa saetplnpel gdssasepgl qaasqpaesp tpqglvlgpp apppppplps
      541 gpayasalpp ppgppppppl pstgpppppp pppplpnqap pppppppapp lpasgifsgs
      601 tsednrpltg laaaiagakl rkvsrvedgs fpgggntgsv slasskadag rgngplplgg
      661 sglmeemsal larrrriaek gstieteqke drnedaepit akapststpe ptrkpwertn
      721 tmngskspvi srpkstpssq psangvqteg ldydrlkqdi ldemrkelak lkeelidair
      781 qelsksnta
//
LOCUS       NP_001351360             296 aa            linear   ROD 09-OCT-2023
DEFINITION  pro-neuregulin-1, membrane-bound isoform isoform 12 [Mus musculus].
ACCESSION   NP_001351360
VERSION     NP_001351360.1
DBSOURCE    REFSEQ: accession NM_001364431.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 296)
  AUTHORS   Mikami Y, Iwase F, Ohshima D, Tomida T and Adachi-Akahane S.
  TITLE     Compensatory role of neuregulin-1 in diabetic cardiomyopathy
  JOURNAL   J Pharmacol Sci 153 (3), 130-141 (2023)
   PUBMED   37770154
  REMARK    GeneRIF: Compensatory role of neuregulin-1 in diabetic
            cardiomyopathy.
REFERENCE   2  (residues 1 to 296)
  AUTHORS   Qiao XY, Wang Y, Zhang W, Li Q, Liu C, Dao JJ, Qiao CM, Cui C, Shen
            YQ and Zhao WJ.
  TITLE     Involvement of CXCL10 in Neuronal Damage under the Condition of
            Spinal Cord Injury and the Potential Therapeutic Effect of Nrg1
  JOURNAL   J Integr Neurosci 22 (4), 96 (2023)
   PUBMED   37519170
  REMARK    GeneRIF: Involvement of CXCL10 in Neuronal Damage under the
            Condition of Spinal Cord Injury and the Potential Therapeutic
            Effect of Nrg1.
REFERENCE   3  (residues 1 to 296)
  AUTHORS   Liu H, Lu P, He S, Luo Y, Fang Y, Benkaci S, Wu B, Wang Y and Zhou
            B.
  TITLE     beta-Catenin regulates endocardial cushion growth by suppressing
            p21
  JOURNAL   Life Sci Alliance 6 (9), e202302163 (2023)
   PUBMED   37385754
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 296)
  AUTHORS   Kong L, Hassinan CW, Gerstner F, Buettner JM, Petigrow JB, Valdivia
            DO, Chan-Cortes MH, Mistri A, Cao A, McGaugh SA, Denton M, Brown S,
            Ross J, Schwab MH, Simon CM and Sumner CJ.
  TITLE     Boosting neuregulin 1 type-III expression hastens SMA motor axon
            maturation
  JOURNAL   Acta Neuropathol Commun 11 (1), 53 (2023)
   PUBMED   36997967
  REMARK    GeneRIF: Boosting neuregulin 1 type-III expression hastens SMA
            motor axon maturation.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 296)
  AUTHORS   Zhang X, Xiao G, Johnson C, Cai Y, Horowitz ZK, Mennicke C, Coffey
            R, Haider M, Threadgill D, Eliscu R, Oldham MC, Greenbaum A and
            Ghashghaei HT.
  TITLE     Bulk and mosaic deletions of Egfr reveal regionally defined
            gliogenesis in the developing mouse forebrain
  JOURNAL   iScience 26 (3), 106242 (2023)
   PUBMED   36915679
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 296)
  AUTHORS   Gassmann M, Casagranda F, Orioli D, Simon H, Lai C, Klein R and
            Lemke G.
  TITLE     Aberrant neural and cardiac development in mice lacking the ErbB4
            neuregulin receptor
  JOURNAL   Nature 378 (6555), 390-394 (1995)
   PUBMED   7477376
REFERENCE   7  (residues 1 to 296)
  AUTHORS   Meyer,D. and Birchmeier,C.
  TITLE     Multiple essential functions of neuregulin in development
  JOURNAL   Nature 378 (6555), 386-390 (1995)
   PUBMED   7477375
  REMARK    Erratum:[Nature 1995 Dec 14;378(6558):753]
REFERENCE   8  (residues 1 to 296)
  AUTHORS   Moscoso LM, Chu GC, Gautam M, Noakes PG, Merlie JP and Sanes JR.
  TITLE     Synapse-associated expression of an acetylcholine receptor-inducing
            protein, ARIA/heregulin, and its putative receptors, ErbB2 and
            ErbB3, in developing mammalian muscle
  JOURNAL   Dev Biol 172 (1), 158-169 (1995)
   PUBMED   7589796
REFERENCE   9  (residues 1 to 296)
  AUTHORS   Yang Y, Spitzer E, Meyer D, Sachs M, Niemann C, Hartmann G, Weidner
            KM, Birchmeier C and Birchmeier W.
  TITLE     Sequential requirement of hepatocyte growth factor and neuregulin
            in the morphogenesis and differentiation of the mammary gland
  JOURNAL   J Cell Biol 131 (1), 215-226 (1995)
   PUBMED   7559778
REFERENCE   10 (residues 1 to 296)
  AUTHORS   Ho WH, Armanini MP, Nuijens A, Phillips HS and Osheroff PL.
  TITLE     Sensory and motor neuron-derived factor. A novel heregulin variant
            highly expressed in sensory and motor neurons
  JOURNAL   J Biol Chem 270 (24), 14523-14532 (1995)
   PUBMED   7782315
  REMARK    Erratum:[J Biol Chem. 1995 Nov 3;270(44):26722. PMID: 7592900]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132407.3 and AK048708.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.166238.1,
                                           SRR1660817.66897.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..296
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 18.75 cM"
     Protein         1..296
                     /product="pro-neuregulin-1, membrane-bound isoform isoform
                     12"
                     /note="heregulin; type III neuregulin 1; type I neuregulin
                     1; pro-neuregulin-1, membrane-bound isoform"
                     /calculated_mol_wt=31273
     Region          <236..279
                     /region_name="PHA02887"
                     /note="EGF-like protein; Provisional"
                     /db_xref="CDD:165214"
     CDS             1..296
                     /gene="Nrg1"
                     /gene_synonym="6030402G23Rik; ARIA; D230005F13Rik; GGF;
                     GGFII; Hgl; HRG; HRGalpha; NDF; Pro-NRG1; SMDF"
                     /coded_by="NM_001364431.1:641..1531"
                     /note="isoform 12 is encoded by transcript variant 12"
                     /db_xref="CCDS:CCDS90382.1"
                     /db_xref="GeneID:211323"
                     /db_xref="MGI:MGI:96083"
ORIGIN      
        1 meiyppdmse gaggrsssps tqlsadpsld glpaaehmpd thtedgrspg llglavpccv
       61 cleaerlrgc lnsekicivp ilaclvslcl ciaglkwvfv dkifeydspt hldpgglgqd
      121 pvisldptaa savlvsseay tspvskaqse aeahvtgqgd hvavasepsa vptrknrlsa
      181 fpplhstppp fpspartpev rtpksgtqpq ttetnlqtap klstststtg tshlikcaek
      241 ektfcvngge cfmvkdlsnp srylckcpne ftgdrcqnyv masfyststp flslpe
//
LOCUS       NP_001157102             764 aa            linear   ROD 09-OCT-2023
DEFINITION  DNA-binding protein SATB1 isoform 1 [Mus musculus].
ACCESSION   NP_001157102
VERSION     NP_001157102.1
DBSOURCE    REFSEQ: accession NM_001163630.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 764)
  AUTHORS   Naito T, Ise M, Tanaka Y, Kohwi-Shigematsu T and Kondo M.
  TITLE     Crucial Roles of SATB1 in Regulation of Thymocyte Migration after
            Positive Selection
  JOURNAL   J Immunol 211 (2), 209-218 (2023)
   PUBMED   37256264
  REMARK    GeneRIF: Crucial Roles of SATB1 in Regulation of Thymocyte
            Migration after Positive Selection.
REFERENCE   2  (residues 1 to 764)
  AUTHORS   Nomura A, Kobayashi T, Seo W, Ohno-Oishi M, Kakugawa K, Muroi S,
            Yoshida H, Endo TA, Moro K and Taniuchi I.
  TITLE     Identification of a novel enhancer essential for Satb1 expression
            in TH2 cells and activated ILC2s
  JOURNAL   Life Sci Alliance 6 (8), e202301897 (2023)
   PUBMED   37193606
  REMARK    GeneRIF: Identification of a novel enhancer essential for Satb1
            expression in TH2 cells and activated ILC2s.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 764)
  AUTHORS   Knowles SJ, Stafford AM, Zaman T, Angara K, Williams MR, Newbern JM
            and Vogt D.
  TITLE     Distinct hyperactive RAS/MAPK alleles converge on common GABAergic
            interneuron core programs
  JOURNAL   Development 150 (10) (2023)
   PUBMED   37254876
REFERENCE   4  (residues 1 to 764)
  AUTHORS   Wang B, Ji L and Bian Q.
  TITLE     SATB1 regulates 3D genome architecture in T cells by constraining
            chromatin interactions surrounding CTCF-binding sites
  JOURNAL   Cell Rep 42 (4), 112323 (2023)
   PUBMED   37000624
  REMARK    GeneRIF: SATB1 regulates 3D genome architecture in T cells by
            constraining chromatin interactions surrounding CTCF-binding sites.
REFERENCE   5  (residues 1 to 764)
  AUTHORS   Vasilopoulos N, Kaplanian A, Vinos M, Katsaiti Y, Christodoulou O,
            Denaxa M and Skaliora I.
  TITLE     The role of selective SATB1 deletion in somatostatin expressing
            interneurons on endogenous network activity and the transition to
            epilepsy
  JOURNAL   J Neurosci Res 101 (4), 424-447 (2023)
   PUBMED   36541427
  REMARK    GeneRIF: The role of selective SATB1 deletion in somatostatin
            expressing interneurons on endogenous network activity and the
            transition to epilepsy.
REFERENCE   6  (residues 1 to 764)
  AUTHORS   Seo J, Lozano MM and Dudley JP.
  TITLE     Nuclear matrix binding regulates SATB1-mediated transcriptional
            repression
  JOURNAL   J Biol Chem 280 (26), 24600-24609 (2005)
   PUBMED   15851481
  REMARK    GeneRIF: SATB1-mediated transcriptional repression is regulated by
            nuclear matrix binding
REFERENCE   7  (residues 1 to 764)
  AUTHORS   Nie H, Maika SD, Tucker PW and Gottlieb PD.
  TITLE     A role for SATB1, a nuclear matrix association region-binding
            protein, in the development of CD8SP thymocytes and peripheral T
            lymphocytes
  JOURNAL   J Immunol 174 (8), 4745-4752 (2005)
   PUBMED   15814699
  REMARK    GeneRIF: essential role for SATB1 late in the development and
            maturation of CD8SP T cells
REFERENCE   8  (residues 1 to 764)
  AUTHORS   Cai S, Han HJ and Kohwi-Shigematsu T.
  TITLE     Tissue-specific nuclear architecture and gene expression regulated
            by SATB1
  JOURNAL   Nat Genet 34 (1), 42-51 (2003)
   PUBMED   12692553
  REMARK    GeneRIF: in thymocyte nuclei, SATB1 has a cage-like 'network'
            distribution circumscribing heterochromatin and selectively tethers
            specialized DNA sequences onto its network
REFERENCE   9  (residues 1 to 764)
  AUTHORS   Alvarez JD, Yasui DH, Niida H, Joh T, Loh DY and Kohwi-Shigematsu
            T.
  TITLE     The MAR-binding protein SATB1 orchestrates temporal and spatial
            expression of multiple genes during T-cell development
  JOURNAL   Genes Dev 14 (5), 521-535 (2000)
   PUBMED   10716941
REFERENCE   10 (residues 1 to 764)
  AUTHORS   Nakagomi K, Kohwi Y, Dickinson LA and Kohwi-Shigematsu T.
  TITLE     A novel DNA-binding motif in the nuclear matrix attachment
            DNA-binding protein SATB1
  JOURNAL   Mol Cell Biol 14 (3), 1852-1860 (1994)
   PUBMED   8114718
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK158518.1, CV556064.1, AK037740.1, AK081385.1, AC131975.28 and
            AW045567.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1-4 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK158518.1, SRR1660817.250693.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..764
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 26.81 cM"
     Protein         1..764
                     /product="DNA-binding protein SATB1 isoform 1"
                     /note="DNA-binding protein Satb1"
                     /calculated_mol_wt=85749
     Region          1..56
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60611.2)"
     Region          20..40
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60611.2)"
     Region          72..170
                     /region_name="ULD"
                     /note="Ubiquitin-like oligomerization domain of SATB;
                     pfam16534"
                     /db_xref="CDD:435405"
     Site            order(75,77,94..98,100,132,134,137..138,144..147,155..156,
                     159..161,163..164)
                     /site_type="other"
                     /note="tetramer interface [polypeptide binding]"
                     /db_xref="CDD:211426"
     Site            136
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q01826; propagated from
                     UniProtKB/Swiss-Prot (Q60611.2)"
     Region          139..143
                     /region_name="Protein interaction. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60611.2)"
     Region          176..247
                     /region_name="CUTL"
                     /note="CUT1-like DNA-binding domain of SATB; pfam16557"
                     /db_xref="CDD:435427"
     Site            185
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q01826; propagated from
                     UniProtKB/Swiss-Prot (Q60611.2)"
     Region          224..278
                     /region_name="Nuclear matrix targeting sequence (NMTS)"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60611.2)"
     Region          224..278
                     /region_name="Nuclear matrix targeting sequence (NMTS).
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60611.2)"
     Site            254..255
                     /site_type="cleavage"
                     /note="Cleavage, by caspases; propagated from
                     UniProtKB/Swiss-Prot (Q60611.2)"
     Region          266..307
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60611.2)"
     Region          372..444
                     /region_name="CUT"
                     /note="CUT domain; pfam02376"
                     /db_xref="CDD:426745"
     Region          450..474
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60611.2)"
     Region          497..567
                     /region_name="CUT"
                     /note="CUT domain; pfam02376"
                     /db_xref="CDD:426745"
     Region          591..650
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60611.2)"
     Site            638
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q60611.2)"
     Region          645..702
                     /region_name="HOX"
                     /note="Homeodomain; smart00389"
                     /db_xref="CDD:197696"
     Site            order(647..650,652,670,676,689,691..692,695..696,698..700,
                     702..703)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     Site            order(648,651,692,695..696,699)
                     /site_type="other"
                     /note="specific DNA base contacts [nucleotide binding]"
                     /db_xref="CDD:238039"
     CDS             1..764
                     /gene="Satb1"
                     /gene_synonym="2610306G12Rik"
                     /coded_by="NM_001163630.1:322..2616"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS28876.1"
                     /db_xref="GeneID:20230"
                     /db_xref="MGI:MGI:105084"
ORIGIN      
        1 mdhlneatqg kehsemsnnv sdpkgppaki arleqngspl grgrlgstgg kmqgvplkhs
       61 ghlmktnlrk gtmlpvfcvv ehyenaieyd ckeehaefvl vrkdmlfnql iemallslgy
      121 shssaaqakg liqvgkwnpv plsyvtdapd atvadmlqdv yhvvtlkiql hscpkledlp
      181 peqwshttvr nalkdllkdm nqsslakecp lsqsmissiv nstyyanvsa akcqefgrwy
      241 khfkktkdmm vemdslsels qqganhvnfg qqpvpgntae qppspaqlsh gsqpsvrtpl
      301 pnlhpglvst pispqlvnqq lvmaqllnqq yavnrllaqq slnqqylnhp ppvsrsmnkp
      361 leqqvstnte vsseiyqwvr delkragisq avfarvafnr tqgllseilr keedpktasq
      421 sllvnlramq nflqlpeaer driyqderer slnaasamgp apllstppsr ppqvktatla
      481 terngkpenn tmninasiyd eiqqemkrak vsqalfakva atksqgwlce llrwkedpsp
      541 enrtlwenls mirrflslpq perdaiyeqe snavhhhgdr pphiihvpae qiqqqqqqqq
      601 qqqqqqqppp pppqpqpqpq agprlpprqp tvassaesde enrqktrprt kisvealgil
      661 qsfiqdvgly pdeeaiqtls aqldlpkyti ikffqnqryy lkhhgklkdn sglevdvaey
      721 kdeellkdle esvqdknant lfsvkleeel svegstdvna dlkd
//
LOCUS       NP_033094                656 aa            linear   ROD 09-OCT-2023
DEFINITION  receptor-interacting serine/threonine-protein kinase 1 [Mus
            musculus].
ACCESSION   NP_033094
VERSION     NP_033094.3
DBSOURCE    REFSEQ: accession NM_009068.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 656)
  AUTHORS   Lu Y, Leng Y, Li Y, Wang J, Wang W, Wang R, Liu Y, Tan Q, Yang W,
            Jiang Y, Cai J, Yuan H, Weng L and Xu Q.
  TITLE     Endothelial RIPK1 protects artery bypass graft against
            arteriosclerosis by regulating SMC growth
  JOURNAL   Sci Adv 9 (35), eadh8939 (2023)
   PUBMED   37647392
  REMARK    GeneRIF: Endothelial RIPK1 protects artery bypass graft against
            arteriosclerosis by regulating SMC growth.
REFERENCE   2  (residues 1 to 656)
  AUTHORS   Sharma BR, Karki R, Rajesh Y and Kanneganti TD.
  TITLE     Immune regulator IRF1 contributes to ZBP1-, AIM2-, RIPK1-, and
            NLRP12-PANoptosome activation and inflammatory cell death
            (PANoptosis)
  JOURNAL   J Biol Chem 299 (9), 105141 (2023)
   PUBMED   37557956
  REMARK    GeneRIF: Immune regulator IRF1 contributes to ZBP1-, AIM2-, RIPK1-,
            and NLRP12-PANoptosome activation and inflammatory cell death
            (PANoptosis).
REFERENCE   3  (residues 1 to 656)
  AUTHORS   Vucur M, Ghallab A, Schneider AT, Adili A, Cheng M, Castoldi M,
            Singer MT, Buttner V, Keysberg LS, Kusgens L, Kohlhepp M, Gorg B,
            Gallage S, Barragan Avila JE, Unger K, Kordes C, Leblond AL,
            Albrecht W, Loosen SH, Lohr C, Jordens MS, Babler A, Hayat S,
            Schumacher D, Koenen MT, Govaere O, Boekschoten MV, Jors S,
            Villacorta-Martin C, Mazzaferro V, Llovet JM, Weiskirchen R, Kather
            JN, Starlinger P, Trauner M, Luedde M, Heij LR, Neumann UP, Keitel
            V, Bode JG, Schneider RK, Tacke F, Levkau B, Lammers T, Fluegen G,
            Alexandrov T, Collins AL, Nelson G, Oakley F, Mann DA, Roderburg C,
            Longerich T, Weber A, Villanueva A, Samson AL, Murphy JM, Kramann
            R, Geisler F, Costa IG, Hengstler JG, Heikenwalder M and Luedde T.
  TITLE     Sublethal necroptosis signaling promotes inflammation and liver
            cancer
  JOURNAL   Immunity 56 (7), 1578-1595 (2023)
   PUBMED   37329888
REFERENCE   4  (residues 1 to 656)
  AUTHORS   Zhang T, Xu D, Trefts E, Lv M, Inuzuka H, Song G, Liu M, Lu J, Liu
            J, Chu C, Wang M, Wang H, Meng H, Liu H, Zhuang Y, Xie X, Dang F,
            Guan D, Men Y, Jiang S, Jiang C, Dai X, Liu J, Wang Z, Yan P, Wang
            J, Tu Z, Babuta M, Erickson E, Hillis AL, Dibble CC, Asara JM,
            Szabo G, Sicinski P, Miao J, Lee YR, Pan L, Shaw RJ, Yuan J and Wei
            W.
  TITLE     Metabolic orchestration of cell death by AMPK-mediated
            phosphorylation of RIPK1
  JOURNAL   Science 380 (6652), 1372-1380 (2023)
   PUBMED   37384704
  REMARK    GeneRIF: Metabolic orchestration of cell death by AMPK-mediated
            phosphorylation of RIPK1.
REFERENCE   5  (residues 1 to 656)
  AUTHORS   Carty F, Layzell S, Barbarulo A, Islam F, Webb LV and Seddon B.
  TITLE     IKK promotes naive T cell survival by repressing RIPK1-dependent
            apoptosis and activating NF-kappaB
  JOURNAL   Sci Signal 16 (791), eabo4094 (2023)
   PUBMED   37368952
  REMARK    GeneRIF: IKK promotes naive T cell survival by repressing
            RIPK1-dependent apoptosis and activating NF-kappaB.
REFERENCE   6  (residues 1 to 656)
  AUTHORS   Kaiserman D, Knaggs S, Scarff KL, Gillard A, Mirza G, Cadman M,
            McKeone R, Denny P, Cooley J, Benarafa C, Remold-O'Donnell E,
            Ragoussis J and Bird PI.
  TITLE     Comparison of human chromosome 6p25 with mouse chromosome 13
            reveals a greatly expanded ov-serpin gene repertoire in the mouse
  JOURNAL   Genomics 79 (3), 349-362 (2002)
   PUBMED   11863365
REFERENCE   7  (residues 1 to 656)
  AUTHORS   Melnick M, Chen H, Zhou Y and Jaskoll T.
  TITLE     Embryonic mouse submandibular salivary gland morphogenesis and the
            TNF/TNF-R1 signal transduction pathway
  JOURNAL   Anat Rec 262 (3), 318-330 (2001)
   PUBMED   11241200
REFERENCE   8  (residues 1 to 656)
  AUTHORS   Hofmann K.
  TITLE     The modular nature of apoptotic signaling proteins
  JOURNAL   Cell Mol Life Sci 55 (8-9), 1113-1128 (1999)
   PUBMED   10442092
  REMARK    Review article
REFERENCE   9  (residues 1 to 656)
  AUTHORS   Kelliher MA, Grimm S, Ishida Y, Kuo F, Stanger BZ and Leder P.
  TITLE     The death domain kinase RIP mediates the TNF-induced NF-kappaB
            signal
  JOURNAL   Immunity 8 (3), 297-303 (1998)
   PUBMED   9529147
REFERENCE   10 (residues 1 to 656)
  AUTHORS   Stanger BZ, Leder P, Lee TH, Kim E and Seed B.
  TITLE     RIP: a novel protein containing a death domain that interacts with
            Fas/APO-1 (CD95) in yeast and causes cell death
  JOURNAL   Cell 81 (4), 513-523 (1995)
   PUBMED   7538908
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC054542.1.
            
            On Aug 28, 2003 this sequence version replaced NP_033094.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054542.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..656
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 14.01 cM"
     Protein         1..656
                     /product="receptor-interacting serine/threonine-protein
                     kinase 1"
                     /EC_number="2.7.11.1"
                     /note="cell death protein RIP; receptor-interacting
                     protein 1; serine/threonine-protein kinase RIP"
                     /calculated_mol_wt=74724
     Site            6
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by IKKA and IKKB.
                     /evidence=ECO:0000269|PubMed:30988283; propagated from
                     UniProtKB/Swiss-Prot (Q60855.1)"
     Region          23..291
                     /region_name="PKc_like"
                     /note="Protein Kinases, catalytic domain; cl21453"
                     /db_xref="CDD:451246"
     Site            order(23..26,29,31,43,45,76,92..95,138,142..143,145,
                     155..156)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270870"
     Site            25
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by IKKA and IKKB.
                     /evidence=ECO:0000269|PubMed:30988283; propagated from
                     UniProtKB/Swiss-Prot (Q60855.1)"
     Site            161
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by RIPK3 and autocatalysis.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q60855.1)"
     Site            166
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by autocatalysis.
                     /evidence=ECO:0000269|PubMed:27819682,
                     ECO:0000269|PubMed:28701375, ECO:0000269|PubMed:29440439,
                     ECO:0000269|PubMed:30988283, ECO:0000269|PubMed:31519886,
                     ECO:0000269|PubMed:31519887; propagated from
                     UniProtKB/Swiss-Prot (Q60855.1)"
     Site            169
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000269|PubMed:30988283; propagated from
                     UniProtKB/Swiss-Prot (Q60855.1)"
     Region          291..567
                     /region_name="Interaction with SQSTM1.
                     /evidence=ECO:0000250|UniProtKB:Q13546"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60855.1)"
     Site            304
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13546; propagated from
                     UniProtKB/Swiss-Prot (Q60855.1)"
     Site            313
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q60855.1)"
     Site            321
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by MAP3K7.
                     /evidence=ECO:0000269|PubMed:28842570,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q60855.1)"
     Site            325..326
                     /site_type="cleavage"
                     /note="Cleavage, by CASP8.
                     /evidence=ECO:0000269|PubMed:31511692,
                     ECO:0000269|PubMed:31827280, ECO:0000269|PubMed:31827281;
                     propagated from UniProtKB/Swiss-Prot (Q60855.1)"
     Region          327..373
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60855.1)"
     Site            332
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by MAP3K7.
                     /evidence=ECO:0000269|PubMed:28842570; propagated from
                     UniProtKB/Swiss-Prot (Q60855.1)"
     Site            334
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by MAP3K7.
                     /evidence=ECO:0000269|PubMed:28842570; propagated from
                     UniProtKB/Swiss-Prot (Q60855.1)"
     Site            383
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q13546; propagated from
                     UniProtKB/Swiss-Prot (Q60855.1)"
     Region          388..423
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60855.1)"
     Region          520..536
                     /region_name="RIP homotypic interaction motif (RHIM).
                     /evidence=ECO:0000269|PubMed:18442983,
                     ECO:0000269|PubMed:27819681, ECO:0000269|PubMed:27819682"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60855.1)"
     Region          568..653
                     /region_name="Death_RIP1"
                     /note="Death Domain of Receptor-Interacting Protein 1;
                     cd08777"
                     /db_xref="CDD:260048"
     CDS             1..656
                     /gene="Ripk1"
                     /gene_synonym="D330015H01Rik; Rinp; RIP; RIP-1; Rip1"
                     /coded_by="NM_009068.3:137..2107"
                     /db_xref="CCDS:CCDS26443.1"
                     /db_xref="GeneID:19766"
                     /db_xref="MGI:MGI:108212"
ORIGIN      
        1 mqpdmsldni kmassdllek tdldsggfgk vslcyhrshg fvilkkvytg pnraeynevl
       61 leegkmmhrl rhsrvvkllg iiieegnysl vmeymekgnl mhvlktqidv plslkgriiv
      121 eaiegmcylh dkgvihkdlk penilvdrdf hikiadlgva sfktwskltk ekdnkqkevs
      181 sttkknnggt lyymapehln dinakpteks dvysfgivlw aifakkepye nvicteqfvi
      241 ciksgnrpnv eeileycpre iislmercwq aipedrptfl gieeefrpfy lshfeeyvee
      301 dvaslkkeyp dqspvlqrmf slqhdcvplp psrsnseqpg slhssqglqm gpveeswfss
      361 speypqdend rsvqaklqee asyhafgifa ekqtkpqprq neaynreeer krrvshdpfa
      421 qqrareniks agarghsdps ttsrgiavqq lswpatqtvw nnglynqhgf gttgtgvwyp
      481 pnlsqmysty ktpvpetnip gstptmpyfs gpvaddliky tifnssgiqi gnhnymdvgl
      541 nsqppnntck eestsrhqai fdnttsltde hlnpirenlg rqwkncarkl gftesqidei
      601 dhdyerdglk ekvyqmlqkw lmregtkgat vgklaqalhq ccridllnhl irasqs
//
LOCUS       NP_001020748             370 aa            linear   ROD 09-OCT-2023
DEFINITION  transcription factor Maf [Mus musculus].
ACCESSION   NP_001020748 XP_620716
VERSION     NP_001020748.2
DBSOURCE    REFSEQ: accession NM_001025577.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 370)
  AUTHORS   Dos Santos M, Shah AM, Zhang Y, Bezprozvannaya S, Chen K, Xu L, Lin
            W, McAnally JR, Bassel-Duby R, Liu N and Olson EN.
  TITLE     Opposing gene regulatory programs governing myofiber development
            and maturation revealed at single nucleus resolution
  JOURNAL   Nat Commun 14 (1), 4333 (2023)
   PUBMED   37468485
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 370)
  AUTHORS   Bao K, Isik Can U, Miller MM, Brown IK, Dell'Aringa M, Dooms H,
            Seibold MA, Scott-Browne J and Lee Reinhardt R.
  TITLE     A bifurcated role for c-Maf in Th2 and Tfh2 cells during helminth
            infection
  JOURNAL   Mucosal Immunol 16 (3), 357-372 (2023)
   PUBMED   37088263
  REMARK    GeneRIF: A bifurcated role for c-Maf in Th2 and Tfh2 cells during
            helminth infection.
REFERENCE   3  (residues 1 to 370)
  AUTHORS   Vanneste D, Bai Q, Hasan S, Peng W, Pirottin D, Schyns J, Marechal
            P, Ruscitti C, Meunier M, Liu Z, Legrand C, Fievez L, Ginhoux F,
            Radermecker C, Bureau F and Marichal T.
  TITLE     MafB-restricted local monocyte proliferation precedes lung
            interstitial macrophage differentiation
  JOURNAL   Nat Immunol 24 (5), 827-840 (2023)
   PUBMED   36928411
REFERENCE   4  (residues 1 to 370)
  AUTHORS   Frezel N, Ranucci M, Foster E, Wende H, Pelczar P, Mendes R, Ganley
            RP, Werynska K, d'Aquin S, Beccarini C, Birchmeier C, Zeilhofer HU
            and Wildner H.
  TITLE     c-Maf-positive spinal cord neurons are critical elements of a
            dorsal horn circuit for mechanical hypersensitivity in neuropathy
  JOURNAL   Cell Rep 42 (4), 112295 (2023)
   PUBMED   36947543
  REMARK    GeneRIF: c-Maf-positive spinal cord neurons are critical elements
            of a dorsal horn circuit for mechanical hypersensitivity in
            neuropathy.
REFERENCE   5  (residues 1 to 370)
  AUTHORS   Fujino M, Morito N, Hayashi T, Ojima M, Ishibashi S, Kuno A,
            Koshiba S, Yamagata K and Takahashi S.
  TITLE     Transcription factor c-Maf deletion improves streptozotocin-induced
            diabetic nephropathy by directly regulating Sglt2 and Glut2
  JOURNAL   JCI Insight 8 (6), e163306 (2023)
   PUBMED   36787192
  REMARK    GeneRIF: Transcription factor c-Maf deletion improves
            streptozotocin-induced diabetic nephropathy by directly regulating
            Sglt2 and Glut2.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 370)
  AUTHORS   Pathak BG, Shaughnessy JD Jr, Meneton P, Greeb J, Shull GE, Jenkins
            NA and Copeland NG.
  TITLE     Mouse chromosomal location of three epithelial sodium channel
            subunit genes and an apical sodium chloride cotransporter gene
  JOURNAL   Genomics 33 (1), 124-127 (1996)
   PUBMED   8617496
REFERENCE   7  (residues 1 to 370)
  AUTHORS   Avraham KB, Fletcher C, Overdier DG, Clevidence DE, Lai E, Costa
            RH, Jenkins NA and Copeland NG.
  TITLE     Murine chromosomal location of eight members of the hepatocyte
            nuclear factor 3/fork head winged helix family of transcription
            factors
  JOURNAL   Genomics 25 (2), 388-393 (1995)
   PUBMED   7789972
REFERENCE   8  (residues 1 to 370)
  AUTHORS   Kurschner C and Morgan JI.
  TITLE     The maf proto-oncogene stimulates transcription from multiple sites
            in a promoter that directs Purkinje neuron-specific gene expression
  JOURNAL   Mol Cell Biol 15 (1), 246-254 (1995)
   PUBMED   7799931
REFERENCE   9  (residues 1 to 370)
  AUTHORS   Bae SC, Ogawa E, Maruyama M, Oka H, Satake M, Shigesada K, Jenkins
            NA, Gilbert DJ, Copeland NG and Ito Y.
  TITLE     PEBP2 alpha B/mouse AML1 consists of multiple isoforms that possess
            differential transactivation potentials
  JOURNAL   Mol Cell Biol 14 (5), 3242-3252 (1994)
   PUBMED   8164679
REFERENCE   10 (residues 1 to 370)
  AUTHORS   Andrews NC, Kotkow KJ, Ney PA, Erdjument-Bromage H, Tempst P and
            Orkin SH.
  TITLE     The ubiquitous subunit of erythroid transcription factor NF-E2 is a
            small basic-leucine zipper protein related to the v-maf oncogene
  JOURNAL   Proc Natl Acad Sci U S A 90 (24), 11488-11492 (1993)
   PUBMED   8265578
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113301.7.
            
            On Jul 29, 2005 this sequence version replaced NP_001020748.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..370
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 62.61 cM"
     Protein         1..370
                     /product="transcription factor Maf"
                     /note="c-Maf long form; proto-oncogene c-maf; V-maf
                     musculoaponeurotic fibrosarcoma oncogene homolog; avian
                     musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene
                     homolog; avian musculoaponeurotic fibrosarcoma oncogene
                     homolog"
                     /calculated_mol_wt=38304
     Region          57..84
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P54843.2)"
     Region          86..119
                     /region_name="Maf_N"
                     /note="Maf N-terminal region; pfam08383"
                     /db_xref="CDD:429961"
     Region          126..370
                     /region_name="Represses ARE-mediated transcription.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P54843.2)"
     Region          175..244
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P54843.2)"
     Region          280..348
                     /region_name="bZIP_Maf_large"
                     /note="Basic leucine zipper (bZIP) domain of large
                     musculoaponeurotic fibrosarcoma (Maf) proteins: a
                     DNA-binding and dimerization domain; cd14718"
                     /db_xref="CDD:269866"
     Region          280..348
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:269866"
     Region          285..310
                     /region_name="Basic motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00978"
                     /note="propagated from UniProtKB/Swiss-Prot (P54843.2)"
     Site            order(287,290..292,294..296,298..300,302..303,305..306)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:269866"
     Site            order(306,313,316..317,320..321,323..324,327..328,
                     330..331,334,337..338,341..342,344..345)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:269866"
     Region          313..334
                     /region_name="Leucine-zipper.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00978"
                     /note="propagated from UniProtKB/Swiss-Prot (P54843.2)"
     CDS             1..370
                     /gene="Maf"
                     /gene_synonym="2810401A20Rik; A230108G15Rik; c-maf"
                     /coded_by="NM_001025577.2:32..1144"
                     /db_xref="CCDS:CCDS40486.1"
                     /db_xref="GeneID:17132"
                     /db_xref="MGI:MGI:96909"
ORIGIN      
        1 maselamnns dlptsplame yvndfdlmkf evkkepvetd riisqcgrli aggslsstpm
       61 stpcssvpps psfsapspgs gseqkahled yywmtgypqq lnpealgfsp edavealisn
      121 shqlqggfdg yargaqqlaa aagagagasl ggsgeemgpa aavvsaviaa aaaqsgaaph
      181 yhhhhhhaag hhhhptagap gaaggasasa sgaggagggg pasagggggg gggggtagag
      241 galhphhaag glhfddrfsd eqlvtmsvre lnrqlrgvsk eevirlkqkr rtlknrgyaq
      301 scrfkrvqqr hvleseknql lqqvdhlkqe isrlvrerda ykekyeklvs ngfrengsss
      361 dnpsspeffm
//
LOCUS       NP_001390654             736 aa            linear   ROD 09-OCT-2023
DEFINITION  transcriptional repressor CTCF isoform 1 [Mus musculus].
ACCESSION   NP_001390654
VERSION     NP_001390654.1
DBSOURCE    REFSEQ: accession NM_001403725.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 736)
  AUTHORS   Hewitt SC, Gruzdev A, Willson CJ, Wu SP, Lydon JP, Galjart N and
            DeMayo FJ.
  TITLE     Chromatin architectural factor CTCF is essential for
            progesterone-dependent uterine maturation
  JOURNAL   FASEB J 37 (8), e23103 (2023)
   PUBMED   37489832
  REMARK    GeneRIF: Chromatin architectural factor CTCF is essential for
            progesterone-dependent uterine maturation.
REFERENCE   2  (residues 1 to 736)
  AUTHORS   Smits WK, Vermeulen C, Hagelaar R, Kimura S, Vroegindeweij EM,
            Buijs-Gladdines JGCAM, van de Geer E, Verstegen MJAM, Splinter E,
            van Reijmersdal SV, Buijs A, Galjart N, van Eyndhoven W, van Min M,
            Kuiper R, Kemmeren P, Mullighan CG, de Laat W and Meijerink JPP.
  TITLE     Elevated enhancer-oncogene contacts and higher oncogene expression
            levels by recurrent CTCF inactivating mutations in acute T cell
            leukemia
  JOURNAL   Cell Rep 42 (4), 112373 (2023)
   PUBMED   37060567
REFERENCE   3  (residues 1 to 736)
  AUTHORS   Wang B, Ji L and Bian Q.
  TITLE     SATB1 regulates 3D genome architecture in T cells by constraining
            chromatin interactions surrounding CTCF-binding sites
  JOURNAL   Cell Rep 42 (4), 112323 (2023)
   PUBMED   37000624
  REMARK    GeneRIF: SATB1 regulates 3D genome architecture in T cells by
            constraining chromatin interactions surrounding CTCF-binding sites.
REFERENCE   4  (residues 1 to 736)
  AUTHORS   Marina-Zarate E, Rodriguez-Ronchel A, Gomez MJ, Sanchez-Cabo F and
            Ramiro AR.
  TITLE     Low-affinity CTCF binding drives transcriptional regulation whereas
            high-affinity binding encompasses architectural functions
  JOURNAL   iScience 26 (3), 106106 (2023)
   PUBMED   36852270
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 736)
  AUTHORS   Hsieh TS, Cattoglio C, Slobodyanyuk E, Hansen AS, Darzacq X and
            Tjian R.
  TITLE     Enhancer-promoter interactions and transcription are largely
            maintained upon acute loss of CTCF, cohesin, WAPL or YY1
  JOURNAL   Nat Genet 54 (12), 1919-1932 (2022)
   PUBMED   36471071
  REMARK    GeneRIF: Enhancer-promoter interactions and transcription are
            largely maintained upon acute loss of CTCF, cohesin, WAPL or YY1.
REFERENCE   6  (residues 1 to 736)
  AUTHORS   Farrell CM, West AG and Felsenfeld G.
  TITLE     Conserved CTCF insulator elements flank the mouse and human
            beta-globin loci
  JOURNAL   Mol Cell Biol 22 (11), 3820-3831 (2002)
   PUBMED   11997516
  REMARK    GeneRIF: Conserved CTCF insulator elements flank the mouse and
            human beta-globin loci.
REFERENCE   7  (residues 1 to 736)
  AUTHORS   Burke LJ, Hollemann T, Pieler T and Renkawitz R.
  TITLE     Molecular cloning and expression of the chromatin insulator protein
            CTCF in Xenopus laevis
  JOURNAL   Mech Dev 113 (1), 95-98 (2002)
   PUBMED   11900981
REFERENCE   8  (residues 1 to 736)
  AUTHORS   Chao W, Huynh KD, Spencer RJ, Davidow LS and Lee JT.
  TITLE     CTCF, a candidate trans-acting factor for X-inactivation choice
  JOURNAL   Science 295 (5553), 345-347 (2002)
   PUBMED   11743158
  REMARK    GeneRIF: It's proposed that Tsix and CTCF together establish a
            regulatable epigenetic switch for X-inactivation.
REFERENCE   9  (residues 1 to 736)
  AUTHORS   Lutz M, Burke LJ, Barreto G, Goeman F, Greb H, Arnold R,
            Schultheiss H, Brehm A, Kouzarides T, Lobanenkov V and Renkawitz R.
  TITLE     Transcriptional repression by the insulator protein CTCF involves
            histone deacetylases
  JOURNAL   Nucleic Acids Res 28 (8), 1707-1713 (2000)
   PUBMED   10734189
REFERENCE   10 (residues 1 to 736)
  AUTHORS   Filippova GN, Fagerlie S, Klenova EM, Myers C, Dehner Y, Goodwin G,
            Neiman PE, Collins SJ and Lobanenkov VV.
  TITLE     An exceptionally conserved transcriptional repressor, CTCF, employs
            different combinations of zinc fingers to bind diverged promoter
            sequences of avian and mammalian c-myc oncogenes
  JOURNAL   Mol Cell Biol 16 (6), 2802-2813 (1996)
   PUBMED   8649389
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127419.3 and AC152826.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422601.1200606.1,
                                           SRR13422600.292784.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..736
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.04 cM"
     Protein         1..736
                     /product="transcriptional repressor CTCF isoform 1"
                     /note="transcriptional repressor CTCF; CTCFL paralog;
                     11-zinc finger protein"
                     /calculated_mol_wt=83615
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          180..211
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61164.2)"
     Region          266..289
                     /region_name="zf-H2C2_5"
                     /note="C2H2-type zinc-finger domain; pfam13909"
                     /db_xref="CDD:404746"
     Region          268..288
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(273,275,277,279..280,283..284,287,301,303,307..308,
                     311..312,315,329,331,333,335..336,339..340,346)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          280..305
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:433230"
     Site            289
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          296..316
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          309..333
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:433230"
     Site            317
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          324..347
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          351..375
                     /region_name="zf-H2C2_5"
                     /note="C2H2-type zinc-finger domain; pfam13909"
                     /db_xref="CDD:404746"
     Region          353..373
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          <366..500
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Site            374
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          381..401
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            402
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          409..426
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          439..457
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          469..489
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(474,476,478,480..481,484..485,488,502,504,508..509,
                     512..513,516,530,532,534,536..537,540..541,545)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          497..517
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          509..534
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:433230"
     Region          525..546
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          557..573
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          573..686
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61164.2)"
     Site            609
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Site            610
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Site            612
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49711; propagated from
                     UniProtKB/Swiss-Prot (Q61164.2)"
     Region          699..726
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61164.2)"
     CDS             1..736
                     /gene="Ctcf"
                     /coded_by="NM_001403725.1:143..2353"
                     /note="isoform 1 is encoded by transcript variant 5"
                     /db_xref="GeneID:13018"
                     /db_xref="MGI:MGI:109447"
ORIGIN      
        1 megeaveaiv eesetfikgk erktyqrrre ggqeedachl pqnqtdggev vqdvnssvqm
       61 vmmeqldptl lqmktevmeg tvapeaeaav ddtqiitlqv vnmeeqpini gelqlvqvpv
      121 pvtvpvatts veelqgayen evskeglaes epmichtlpl pegfqvvkvg angevetleq
      181 gelppqedss wqkdpdyqpp akktkktkks klryteegkd vdvsvydfee eqqegllsev
      241 naekvvgnmk ppkptkikkk gvkktfqcel csytcprrsn ldrhmkshtd erphkchlcg
      301 rafrtvtllr nhlnthtgtr phkcpdcdma fvtsgelvrh rrykhthekp fkcsmcdyas
      361 vevsklkrhi rshtgerpfq cslcsyasrd tyklkrhmrt hsgekpyecy icharftqsg
      421 tmkmhilqkh tenvakfhcp hcdtviarks dlgvhlrkqh syieqgkkcr ycdavfhery
      481 aliqhqkshk nekrfkcdqc dyacrqerhm imhkrthtge kpyacshcdk tfrqkqlldm
      541 hfkryhdpnf vpaafvcskc gktftrrntm arhadncagp dgvegengge tkkskrgrkr
      601 kmrskkedss dseenaepdl ddneeeeepa veiepepepq pqpppppqpv apapppakkr
      661 rgrppgrtnq pkqnqptaii qvedqntgai eniivevkke pdaepaegee eeaqaattda
      721 pngdltpemi lsmmdr
//
LOCUS       NP_035191                666 aa            linear   ROD 09-OCT-2023
DEFINITION  protein-arginine deiminase type-4 [Mus musculus].
ACCESSION   NP_035191 XP_920193
VERSION     NP_035191.2
DBSOURCE    REFSEQ: accession NM_011061.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 666)
  AUTHORS   Singh AK, Khan S, Moore D, Andrews S and Christophorou MA.
  TITLE     Transcriptomic analysis of PADI4 target genes during multi-lineage
            differentiation of embryonic stem cells
  JOURNAL   Philos Trans R Soc Lond B Biol Sci 378 (1890), 20220236 (2023)
   PUBMED   37778387
  REMARK    GeneRIF: Transcriptomic analysis of PADI4 target genes during
            multi-lineage differentiation of embryonic stem cells.
REFERENCE   2  (residues 1 to 666)
  AUTHORS   Indeglia A, Leung JC, Miller SA, Leu JI, Dougherty JF, Clarke NL,
            Kirven NA, Shao C, Ke L, Lovell S, Barnoud T, Lu DY, Lin C, Kannan
            T, Battaile KP, Yang THL, Batista Oliva I, Claiborne DT, Vogel P,
            Liu L, Liu Q, Nefedova Y, Cassel J, Auslander N, Kossenkov AV,
            Karanicolas J and Murphy ME.
  TITLE     An African-Specific Variant of TP53 Reveals PADI4 as a Regulator of
            p53-Mediated Tumor Suppression
  JOURNAL   Cancer Discov 13 (7), 1696-1719 (2023)
   PUBMED   37140445
  REMARK    GeneRIF: An African-Specific Variant of TP53 Reveals PADI4 as a
            Regulator of p53-Mediated Tumor Suppression.
REFERENCE   3  (residues 1 to 666)
  AUTHORS   Circiumaru A, Afonso MG, Wahamaa H, Krishnamurthy A, Hansson M,
            Mathsson-Alm L, Keszei M, Stalesen R, Ottosson L, de Vries C,
            Shelef MA, Malmstrom V, Klareskog L, Catrina AI, Gronwall C,
            Hensvold A and Rethi B.
  TITLE     Anti-Citrullinated Protein Antibody Reactivity towards
            Neutrophil-Derived Antigens: Clonal Diversity and Inter-Individual
            Variation
  JOURNAL   Biomolecules 13 (4), 630 (2023)
   PUBMED   37189377
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 666)
  AUTHORS   Sano M, Maejima Y, Nakagama S, Shiheido-Watanabe Y, Tamura N, Hirao
            K, Isobe M and Sasano T.
  TITLE     Neutrophil extracellular traps-mediated Beclin-1 suppression
            aggravates atherosclerosis by inhibiting macrophage autophagy
  JOURNAL   Front Cell Dev Biol 10, 876147 (2022)
   PUBMED   35923856
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 666)
  AUTHORS   Young C, Russell JR, Van De Lagemaat LN, Lawson H, Mapperley C,
            Kranc KR and Christophorou MA.
  TITLE     Intrinsic function of the peptidylarginine deiminase PADI4 is
            dispensable for normal haematopoiesis
  JOURNAL   Biol Open 11 (6) (2022)
   PUBMED   35603697
REFERENCE   6  (residues 1 to 666)
  AUTHORS   Nguyen C, Singson E, Kim JY, Cornelius JG, Attia R, Doyle ME,
            Bulosan M, Cha S and Peck AB.
  TITLE     Sjogren's syndrome-like disease of C57BL/6.NOD-Aec1 Aec2 mice:
            gender differences in keratoconjunctivitis sicca defined by a
            cross-over in the chromosome 3 Aec1 locus
  JOURNAL   Scand J Immunol 64 (3), 295-307 (2006)
   PUBMED   16918699
REFERENCE   7  (residues 1 to 666)
  AUTHORS   Liu M, Oh A, Calarco P, Yamada M, Coonrod SA and Talbot P.
  TITLE     Peptidylarginine deiminase (PAD) is a mouse cortical granule
            protein that plays a role in preimplantation embryonic development
  JOURNAL   Reprod Biol Endocrinol 3, 42 (2005)
   PUBMED   16137333
  REMARK    Publication Status: Online-Only
REFERENCE   8  (residues 1 to 666)
  AUTHORS   Cuthbert GL, Daujat S, Snowden AW, Erdjument-Bromage H, Hagiwara T,
            Yamada M, Schneider R, Gregory PD, Tempst P, Bannister AJ and
            Kouzarides T.
  TITLE     Histone deimination antagonizes arginine methylation
  JOURNAL   Cell 118 (5), 545-553 (2004)
   PUBMED   15339660
REFERENCE   9  (residues 1 to 666)
  AUTHORS   Chavanas S, Mechin MC, Takahara H, Kawada A, Nachat R, Serre G and
            Simon M.
  TITLE     Comparative analysis of the mouse and human peptidylarginine
            deiminase gene clusters reveals highly conserved non-coding
            segments and a new human gene, PADI6
  JOURNAL   Gene 330, 19-27 (2004)
   PUBMED   15087120
REFERENCE   10 (residues 1 to 666)
  AUTHORS   Rus'd AA, Ikejiri Y, Ono H, Yonekawa T, Shiraiwa M, Kawada A and
            Takahara H.
  TITLE     Molecular cloning of cDNAs of mouse peptidylarginine deiminase type
            I, type III and type IV, and the expression pattern of type I in
            mouse
  JOURNAL   Eur J Biochem 259 (3), 660-669 (1999)
   PUBMED   10092850
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK137625.1, AB013850.1, AI645912.1 and BY544067.1.
            
            On Sep 6, 2007 this sequence version replaced NP_035191.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK137625.1, AB013850.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..666
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 72.34 cM"
     Protein         1..666
                     /product="protein-arginine deiminase type-4"
                     /EC_number="3.5.3.15"
                     /note="peptidylarginine deiminase IV; protein-arginine
                     deiminase type IV; PAD type IV"
                     /calculated_mol_wt=74284
     Region          1..111
                     /region_name="PAD_N"
                     /note="Protein-arginine deiminase (PAD) N-terminal domain;
                     pfam08526"
                     /db_xref="CDD:430055"
     Region          113..273
                     /region_name="PAD_M"
                     /note="Protein-arginine deiminase (PAD) middle domain;
                     pfam08527"
                     /db_xref="CDD:430056"
     Region          283..663
                     /region_name="PAD"
                     /note="Protein-arginine deiminase (PAD); pfam03068"
                     /db_xref="CDD:427121"
     CDS             1..666
                     /gene="Padi4"
                     /gene_synonym="Pad4; Pdi4"
                     /coded_by="NM_011061.2:24..2024"
                     /db_xref="CCDS:CCDS18854.1"
                     /db_xref="GeneID:18602"
                     /db_xref="MGI:MGI:1338898"
ORIGIN      
        1 maqgavihva peqpthavcv vgtatpldvr gsapkgyttf gitaspgviv dvihgppvkk
       61 stmgaskwpl dpelevtlqv kaassrtdde kvrvsyygpk tspvqaliyi tgvelslsad
      121 vtrtgrvkpa qagkdqstwt wgpggrgail lvncdkedpq asgmdfeddk ildnkdlqdm
      181 spmtlstktp kdffekyqlv levpkakmnr vrvfratrgk lpsrykvalg pqqfsyclel
      241 pggqhstdfy veglafpdad fkglipltis lldksnpelp ealvfqdsvt frvapwimtp
      301 ntqppqevyv crvsdnedfl kslatltkka kckltvcpee eniddqwmqd emeigyiqap
      361 hktlpvvfds prdrglkdfp vkrvmgpnfg yvtrklymse ltgldafgnl evsppvtvrg
      421 keyplgrili gnsgyssses rdmhqalqdf lsaqqvqapv rlfsdwlfvg hvdeflsfvp
      481 ardkqgfrll lsspracyql fqelqsqghg eatlfeglkr krqtineils nkklrdqnay
      541 vescidwnra vlkrelglae gdiidipqlf klagnsrgns kaqaffpnmv nmlvlgkylg
      601 ipkpfgpiid ghccleeevr shleplglhc tfindfytyh vyngevhcgt nvrrkpftfk
      661 wwhmvp
//
LOCUS       NP_062340                147 aa            linear   ROD 09-OCT-2023
DEFINITION  allograft inflammatory factor 1 isoform a [Mus musculus].
ACCESSION   NP_062340
VERSION     NP_062340.1
DBSOURCE    REFSEQ: accession NM_019467.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 147)
  AUTHORS   Altounian M, Bellon A and Mann F.
  TITLE     Neuronal miR-17-5p contributes to interhemispheric cortical
            connectivity defects induced by prenatal alcohol exposure
  JOURNAL   Cell Rep 42 (9), 113020 (2023)
   PUBMED   37610874
REFERENCE   2  (residues 1 to 147)
  AUTHORS   Rodriguez-Lopez A, Torres-Paniagua AM, Acero G, Diaz G and
            Gevorkian G.
  TITLE     Increased TSPO expression, pyroglutamate-modified amyloid beta
            (AbetaN3(pE)) accumulation and transient clustering of microglia in
            the thalamus of Tg-SwDI mice
  JOURNAL   J Neuroimmunol 382, 578150 (2023)
   PUBMED   37467699
  REMARK    GeneRIF: Increased TSPO expression, pyroglutamate-modified amyloid
            beta (AbetaN3(pE)) accumulation and transient clustering of
            microglia in the thalamus of Tg-SwDI mice.
REFERENCE   3  (residues 1 to 147)
  AUTHORS   Cao B, Xia Y, Cai Z, Wang Z, Tang C and Song Y.
  TITLE     Construction of a Brain-specific SLC23A2 Gene Knockout Mice Model
  JOURNAL   Neuroscience 524, 137-148 (2023)
   PUBMED   37330196
REFERENCE   4  (residues 1 to 147)
  AUTHORS   Meng H, Zhao Y, Li Y, Fan H, Yi X, Meng X, Wang P, Fu F, Wu S and
            Wang Y.
  TITLE     Evidence for developmental vascular-associated necroptosis and its
            contribution to venous-lymphatic endothelial differentiation
  JOURNAL   Front Cell Dev Biol 11, 1229788 (2023)
   PUBMED   37576598
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 147)
  AUTHORS   Waldhauser V, Baroti T, Frob F and Wegner M.
  TITLE     PBAF Subunit Pbrm1 Selectively Influences the Transition from
            Progenitors to Pre-Myelinating Cells during Oligodendrocyte
            Development
  JOURNAL   Cells 12 (12), 1556 (2023)
   PUBMED   37371026
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 147)
  AUTHORS   Sasaki Y, Ohsawa K, Kanazawa H, Kohsaka S and Imai Y.
  TITLE     Iba1 is an actin-cross-linking protein in macrophages/microglia
  JOURNAL   Biochem Biophys Res Commun 286 (2), 292-297 (2001)
   PUBMED   11500035
REFERENCE   7  (residues 1 to 147)
  AUTHORS   Ohsawa K, Imai Y, Kanazawa H, Sasaki Y and Kohsaka S.
  TITLE     Involvement of Iba1 in membrane ruffling and phagocytosis of
            macrophages/microglia
  JOURNAL   J Cell Sci 113 (Pt 17), 3073-3084 (2000)
   PUBMED   10934045
REFERENCE   8  (residues 1 to 147)
  AUTHORS   Allcock RJ, Martin AM and Price P.
  TITLE     The mouse as a model for the effects of MHC genes on human disease
  JOURNAL   Immunol Today 21 (7), 328-332 (2000)
   PUBMED   10871872
  REMARK    Review article
REFERENCE   9  (residues 1 to 147)
  AUTHORS   Handel-Fernandez ME, Kurimoto I, Streilein JW and Vincek V.
  TITLE     Genetic mapping and physical cloning of UVB susceptibility region
            in mice
  JOURNAL   J Invest Dermatol 113 (2), 224-229 (1999)
   PUBMED   10469308
REFERENCE   10 (residues 1 to 147)
  AUTHORS   Lund T, Shaikh S, Kendall E, Campbell RD, Hattori M, Makino S and
            Cooke A.
  TITLE     RFLP analysis of the MHC class III region defines unique haplotypes
            for the non-obese diabetic, cataract Shionogi and the non-obese
            non-diabetic mouse strains
  JOURNAL   Diabetologia 36 (8), 727-733 (1993)
   PUBMED   8104833
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CR974444.18.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK006184.1, AK006562.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..147
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.59 cM"
     Protein         1..147
                     /product="allograft inflammatory factor 1 isoform a"
                     /note="testis specific; ionized calcium binding adapter
                     molecule 1"
                     /calculated_mol_wt=16779
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylserine.
                     /evidence=ECO:0000250|UniProtKB:P81076; propagated from
                     UniProtKB/Swiss-Prot (O70200.1)"
     Site            11
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P55008; propagated from
                     UniProtKB/Swiss-Prot (O70200.1)"
     Region          <48..113
                     /region_name="PTZ00184"
                     /note="calmodulin; Provisional"
                     /db_xref="CDD:185504"
     Region          128..147
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O70200.1)"
     CDS             1..147
                     /gene="Aif1"
                     /gene_synonym="AIF-1; D17H6S50E; G1; Iba1"
                     /coded_by="NM_019467.4:315..758"
                     /note="isoform a is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS28689.1"
                     /db_xref="GeneID:11629"
                     /db_xref="MGI:MGI:1343098"
ORIGIN      
        1 msqsrdlqgg kafgllkaqq eerleginkq flddpkysnd edlpskleaf kvkymefdln
       61 gngdidimsl krmleklgvp kthlelkrli revssgseet fsysdflrmm lgkrsailrm
      121 ilmyeeknke hkrptgppak kaiselp
//
LOCUS       NP_076402                977 aa            linear   ROD 09-OCT-2023
DEFINITION  serine/threonine-protein kinase/endoribonuclease IRE1 precursor
            [Mus musculus].
ACCESSION   NP_076402
VERSION     NP_076402.1
DBSOURCE    REFSEQ: accession NM_023913.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 977)
  AUTHORS   Yang X, Zhou T, Wang X, Xia Y, Cao X, Cheng X, Cao Y, Ma P, Ma H,
            Qin A and Zhao J.
  TITLE     Loss of DDRGK1 impairs IRE1alpha UFMylation in spondyloepiphyseal
            dysplasia
  JOURNAL   Int J Biol Sci 19 (15), 4709-4725 (2023)
   PUBMED   37781516
  REMARK    GeneRIF: Loss of DDRGK1 impairs IRE1alpha UFMylation in
            spondyloepiphyseal dysplasia.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 977)
  AUTHORS   Flores-Santibanez F, Rennen S, Fernandez D, De Nolf C, Van De Velde
            E, Gaete Gonzalez S, Fuentes C, Moreno C, Figueroa D, Lladser A,
            Iwawaki T, Bono MR, Janssens S and Osorio F.
  TITLE     Nuanced role for dendritic cell intrinsic IRE1 RNase in the
            regulation of antitumor adaptive immunity
  JOURNAL   Front Immunol 14, 1209588 (2023)
   PUBMED   37346037
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 977)
  AUTHORS   Knaus LS, Basilico B, Malzl D, Gerykova Bujalkova M, Smogavec M,
            Schwarz LA, Gorkiewicz S, Amberg N, Pauler FM, Knittl-Frank C,
            Tassinari M, Maulide N, Rulicke T, Menche J, Hippenmeyer S and
            Novarino G.
  TITLE     Large neutral amino acid levels tune perinatal neuronal
            excitability and survival
  JOURNAL   Cell 186 (9), 1950-1967 (2023)
   PUBMED   36996814
REFERENCE   4  (residues 1 to 977)
  AUTHORS   Massoudi D, Gorman S, Kuo YM, Iwawaki T, Oakes SA, Papa FR and
            Gould DB.
  TITLE     Deletion of the Unfolded Protein Response Transducer IRE1alpha Is
            Detrimental to Aging Photoreceptors and to ER Stress-Mediated
            Retinal Degeneration
  JOURNAL   Invest Ophthalmol Vis Sci 64 (4), 30 (2023)
   PUBMED   37097227
  REMARK    GeneRIF: Deletion of the Unfolded Protein Response Transducer
            IRE1alpha Is Detrimental to Aging Photoreceptors and to ER
            Stress-Mediated Retinal Degeneration.
REFERENCE   5  (residues 1 to 977)
  AUTHORS   Park EJ, Kim HS, Lee DH, Kim SM, Yoon JS, Lee JM, Im SJ, Lee H, Lee
            MW and Lee CW.
  TITLE     Ssu72 phosphatase is essential for thermogenic adaptation by
            regulating cytosolic translation
  JOURNAL   Nat Commun 14 (1), 1097 (2023)
   PUBMED   36841836
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 977)
  AUTHORS   Miyoshi K, Katayama T, Imaizumi K, Taniguchi M, Mori Y, Hitomi J,
            Yui D, Manabe T, Gomi F, Yoneda T and Tohyama M.
  TITLE     Characterization of mouse Ire1 alpha: cloning, mRNA localization in
            the brain and functional analysis in a neural cell line
  JOURNAL   Brain Res Mol Brain Res 85 (1-2), 68-76 (2000)
   PUBMED   11146108
REFERENCE   7  (residues 1 to 977)
  AUTHORS   Harding HP, Zhang Y, Bertolotti A, Zeng H and Ron D.
  TITLE     Perk is essential for translational regulation and cell survival
            during the unfolded protein response
  JOURNAL   Mol Cell 5 (5), 897-904 (2000)
   PUBMED   10882126
REFERENCE   8  (residues 1 to 977)
  AUTHORS   Urano F, Wang X, Bertolotti A, Zhang Y, Chung P, Harding HP and Ron
            D.
  TITLE     Coupling of stress in the ER to activation of JNK protein kinases
            by transmembrane protein kinase IRE1
  JOURNAL   Science 287 (5453), 664-666 (2000)
   PUBMED   10650002
REFERENCE   9  (residues 1 to 977)
  AUTHORS   Araki K, Imaizumi T, Sekimoto T, Yoshinobu K, Yoshimuta J, Akizuki
            M, Miura K, Araki M and Yamamura K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   10 (residues 1 to 977)
  AUTHORS   Wang XZ, Harding HP, Zhang Y, Jolicoeur EM, Kuroda M and Ron D.
  TITLE     Cloning of mammalian Ire1 reveals diversity in the ER stress
            responses
  JOURNAL   EMBO J 17 (19), 5708-5717 (1998)
   PUBMED   9755171
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB031332.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB031332.1, SRR10223970.14812.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..977
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 69.14 cM"
     Protein         1..977
                     /product="serine/threonine-protein kinase/endoribonuclease
                     IRE1 precursor"
                     /EC_number="2.7.11.1"
                     /note="serine/threonine-protein kinase/endoribonuclease
                     IRE1; ire1-alpha; inositol-requiring protein 1;
                     endoplasmic reticulum-to-nucleus signaling 1;
                     inositol-requiring 1 alpha; endoplasmic reticulum (ER) to
                     nucleus signalling 1"
                     /calculated_mol_wt=108064
     sig_peptide     1..20
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=2139
     Region          32..300
                     /region_name="Luminal_IRE1"
                     /note="The Luminal domain, a dimerization domain, of the
                     Serine/Threonine protein kinase, Inositol-requiring
                     protein 1; cd09769"
                     /db_xref="CDD:188875"
     Site            order(108..112,118,120..123,125..127,139,141..143,146,
                     159..160,168,170,185,187..189)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:188875"
     Site            178
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9EQY0.1)"
     Site            446..466
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQY0.1)"
     Region          498..559
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQY0.1)"
     Region          568..833
                     /region_name="STKc_IRE1"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Inositol-requiring protein 1; cd13982"
                     /db_xref="CDD:270884"
     Site            order(568,591..592,594,617..618,620,622,627..631,643,674,
                     677..678,681..682,706,824,827)
                     /site_type="other"
                     /note="dimer interface (back-to-back) [polypeptide
                     binding]"
                     /db_xref="CDD:270884"
     Site            order(574,588,723..724,753,797..799,822)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:270884"
     Site            order(577..581,586,597,599,626,642..645,648,650,688,690,
                     692..693,695,711,714,733..736)
                     /site_type="active"
                     /db_xref="CDD:270884"
     Site            order(577..581,584,586,597,599,626,642..643,645,648,
                     692..693,695,711)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270884"
     Site            order(579,582..583,585,600,602,634,636..637,779..780,
                     782..783,786)
                     /site_type="other"
                     /note="dimer interface (face-to-face) [polypeptide
                     binding]"
                     /db_xref="CDD:270884"
     Site            order(581,648,650,688,690,692,714,733..736)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270884"
     Site            order(710..725,729..736)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270884"
     Site            724
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75460; propagated from
                     UniProtKB/Swiss-Prot (Q9EQY0.1)"
     Site            729
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:35975910; propagated from
                     UniProtKB/Swiss-Prot (Q9EQY0.1)"
     Region          836..961
                     /region_name="RNase_Ire1"
                     /note="RNase domain (also known as the kinase extension
                     nuclease domain) of Ire1; cd10422"
                     /db_xref="CDD:199217"
     Site            order(836..837,840,844,908,926,956,959..960)
                     /site_type="other"
                     /note="ligand binding site [chemical binding]"
                     /db_xref="CDD:199217"
     Site            order(838,934,938,941..942,946)
                     /site_type="other"
                     /note="kinase interface [polypeptide binding]"
                     /db_xref="CDD:199217"
     Site            order(840,844,847..848,905,908..909,912,925..927,955..956,
                     959)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:199217"
     Site            892
                     /site_type="other"
                     /note="Interacts with hydroxy-aryl-aldehyde inhibitors.
                     /evidence=ECO:0000269|PubMed:25164867; propagated from
                     UniProtKB/Swiss-Prot (Q9EQY0.1)"
     Region          906..907
                     /region_name="Interacts with hydroxy-aryl-aldehyde
                     inhibitors. /evidence=ECO:0000269|PubMed:25164867"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9EQY0.1)"
     CDS             1..977
                     /gene="Ern1"
                     /gene_synonym="9030414B18Rik; Ire1a; Ire1alpha; Ire1p"
                     /coded_by="NM_023913.2:121..3054"
                     /db_xref="CCDS:CCDS25556.1"
                     /db_xref="GeneID:78943"
                     /db_xref="MGI:MGI:1930134"
ORIGIN      
        1 mparwlllll alllpppgpg sfgrtstvtl petllfvstl dgslhavskr tgsikwtlke
       61 dpvlqvpthv eepaflpdpn dgslytlggk nnegltklpf tipelvqasp crssdgilym
      121 gkkqdiwyvi dlltgekqqt lssafadslc pstsllylgr teytitmydt ktrelrwnat
      181 yfdyaaslpe ddvdykmshf vsngdglvvt vdsesgdvlw iqnyaspvva fyvwqgevlr
      241 kvvhinvave tlryltfmsg evgritkwky pfpketeaks kltptlyvgk ystslyasps
      301 mvhegvavvp rgstlplleg pqtdgvtigd kgecvitpst dlkfdpglkg ksklnylrny
      361 wllighhetp lsastkmler fpnnlpkhre nvipadsekr sfeevinivg qtsdntpttv
      421 sqdveeklar apakpeapvd smlkdmatii lstfllvgwv afiityplsv hqqrqlqhqq
      481 fqkelekiql lqqqqlpfhp hgdltqdpef ldssgpfses sgtsspspsp rasnhslhps
      541 ssasragtsp sleqddedee trmvivgkis fcpkdvlghg aegtivykgm fdnrdvavkr
      601 ilpecfsfad revqllresd ehpnviryfc tekdrqfqyi aielcaatlq eyveqkdfah
      661 lglepitllh qttsglahlh slnivhrdlk phnillsmpn ahgrikamis dfglckklav
      721 grhsfsrrsg vpgtegwiap emlsedckdn ptytvdifsa gcvfyyvise gnhpfgkslq
      781 rqanillgac nldcfhsdkh edviarelie kmiamdpqqr psakhvlkhp ffwslekqlq
      841 ffqdvsdrie kealdgpivr qlerggravv kmdwrenitv plqtdlrkfr tykggsvrdl
      901 lramrnkkhh yrelpvevqe tlgsipddfv ryftsrfphl lshtyqamel crherlfqty
      961 ywheptepqp pvipyal
//
LOCUS       NP_001278108             452 aa            linear   ROD 09-OCT-2023
DEFINITION  nuclear factor of activated T-cells, cytoplasmic 2 isoform c [Mus
            musculus].
ACCESSION   NP_001278108 XP_006498959
VERSION     NP_001278108.1
DBSOURCE    REFSEQ: accession NM_001291179.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 452)
  AUTHORS   Fu Y, Wang J, Liu C, Liao K, Gao X, Tang R, Fan B, Hong Y, Xiao N,
            Xiao C and Liu WH.
  TITLE     Glycogen synthase kinase 3 controls T-cell exhaustion by regulating
            NFAT activation
  JOURNAL   Cell Mol Immunol 20 (10), 1127-1139 (2023)
   PUBMED   37553428
  REMARK    GeneRIF: Glycogen synthase kinase 3 controls T-cell exhaustion by
            regulating NFAT activation.
REFERENCE   2  (residues 1 to 452)
  AUTHORS   Wan X, Zhao S, Dai Y, Zhang J, Shen Y, Gong L and Le Q.
  TITLE     WNT16b promotes the proliferation and self-renewal of human limbal
            epithelial stem/progenitor cells via activating the
            calcium/calcineurin A/NFATC2 pathway
  JOURNAL   Cell Prolif 56 (10), e13460 (2023)
   PUBMED   36974338
  REMARK    GeneRIF: WNT16b promotes the proliferation and self-renewal of
            human limbal epithelial stem/progenitor cells via activating the
            calcium/calcineurin A/NFATC2 pathway.
REFERENCE   3  (residues 1 to 452)
  AUTHORS   Jiang F, Guo Y, Hu L, Zhang M, Meng J, Si Y and Shi H.
  TITLE     Role of nuclear factor of activated T Cells-1 in Sepsis-induced
            behavioral deficits in mice
  JOURNAL   Brain Res 1806, 148299 (2023)
   PUBMED   36842570
REFERENCE   4  (residues 1 to 452)
  AUTHORS   Nagai J, Lin J and Boyce JA.
  TITLE     Macrophage P2Y6 Receptor Signaling Selectively Activates NFATC2 and
            Suppresses Allergic Lung Inflammation
  JOURNAL   J Immunol 209 (12), 2293-2303 (2022)
   PUBMED   36307120
  REMARK    GeneRIF: Macrophage P2Y6 Receptor Signaling Selectively Activates
            NFATC2 and Suppresses Allergic Lung Inflammation.
REFERENCE   5  (residues 1 to 452)
  AUTHORS   Zhu L, Zhou X, Gu M, Kim J, Li Y, Ko CJ, Xie X, Gao T, Cheng X and
            Sun SC.
  TITLE     Dapl1 controls NFATc2 activation to regulate CD8+ T cell exhaustion
            and responses in chronic infection and cancer
  JOURNAL   Nat Cell Biol 24 (7), 1165-1176 (2022)
   PUBMED   35773432
REFERENCE   6  (residues 1 to 452)
  AUTHORS   Vihma H, Pruunsild P and Timmusk T.
  TITLE     Alternative splicing and expression of human and mouse NFAT genes
  JOURNAL   Genomics 92 (5), 279-291 (2008)
   PUBMED   18675896
REFERENCE   7  (residues 1 to 452)
  AUTHORS   Ho SN, Thomas DJ, Timmerman LA, Li X, Francke U and Crabtree GR.
  TITLE     NFATc3, a lymphoid-specific NFATc family member that is
            calcium-regulated and exhibits distinct DNA binding specificity
  JOURNAL   J Biol Chem 270 (34), 19898-19907 (1995)
   PUBMED   7650004
REFERENCE   8  (residues 1 to 452)
  AUTHORS   Jain J, Burgeon E, Badalian TM, Hogan PG and Rao A.
  TITLE     A similar DNA-binding motif in NFAT family proteins and the Rel
            homology region
  JOURNAL   J Biol Chem 270 (8), 4138-4145 (1995)
   PUBMED   7876165
REFERENCE   9  (residues 1 to 452)
  AUTHORS   Li X, Ho SN, Luna J, Giacalone J, Thomas DJ, Timmerman LA, Crabtree
            GR and Francke U.
  TITLE     Cloning and chromosomal localization of the human and murine genes
            for the T-cell transcription factors NFATc and NFATp
  JOURNAL   Cytogenet Cell Genet 68 (3-4), 185-191 (1995)
   PUBMED   7842733
REFERENCE   10 (residues 1 to 452)
  AUTHORS   Ho AM, Jain J, Rao A and Hogan PG.
  TITLE     Expression of the transcription factor NFATp in a neuronal cell
            line and in the murine nervous system
  JOURNAL   J Biol Chem 269 (45), 28181-28186 (1994)
   PUBMED   7961754
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK135414.1, EU887602.1 and AW049827.1.
            
            On Mar 27, 2014 this sequence version replaced XP_006498959.1.
            
            Transcript Variant: This variant (16, also known as IB-IIS-VIIa)
            contains alternate 5' and 3' exon structure, and it thus differs in
            both UTRs, initiates translation at a downstream in-frame start
            codon, and differs in the 3' coding region, compared to variant 1.
            The encoded isoform (c) is shorter at the N-terminus and has a
            distinct C-terminus, compared to isoform a. Both variants 2 and 16
            encode isoform c.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU887602.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..452
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 88.91 cM"
     Protein         1..452
                     /product="nuclear factor of activated T-cells, cytoplasmic
                     2 isoform c"
                     /note="nuclear factor of activated T-cells, cytoplasmic 2;
                     NFAT pre-existing subunit; T-cell transcription factor
                     NFAT1"
                     /calculated_mol_wt=48777
     Region          179..353
                     /region_name="RHD-n_NFAT"
                     /note="N-terminal sub-domain of the Rel homology domain
                     (RHD) of nuclear factor of activated T-cells (NFAT)
                     proteins; cd07881"
                     /db_xref="CDD:143641"
     Site            order(202,205,207..208,210..212,260,301,303..304,318..319,
                     321,352)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143641"
     Region          358..>397
                     /region_name="IPT"
                     /note="Immunoglobulin-like fold, Plexins, Transcription
                     factors (IPT). IPTs are also known as Transcription factor
                     ImmunoGlobin (TIG) domains. They are present in
                     intracellular transcription factors, cell surface
                     receptors (such as plexins and scatter factor...; cl15674"
                     /db_xref="CDD:449574"
     CDS             1..452
                     /gene="Nfatc2"
                     /gene_synonym="NF-ATc2; NF-ATp; NFAT1; NFAT1-D; Nfatp"
                     /coded_by="NM_001291179.1:318..1676"
                     /note="isoform c is encoded by transcript variant 16"
                     /db_xref="CCDS:CCDS17114.1"
                     /db_xref="GeneID:18019"
                     /db_xref="MGI:MGI:102463"
ORIGIN      
        1 msprtslaed sclgrhspvp rpasrssspg akrrhscaea lvaplpaasp qrsrspspqp
       61 sphvalqdds ipagypptag savlmdalnt latdspcgip skiwktspdp tpvstapska
      121 glarhiyptv eflgpceqee rrnsapesil lvpptwpkql vpaipicsip vtaslpplew
      181 plsnqsgsye lrievqpkph hrahyetegs rgavkaptgg hpvvqlhgym enkplglqif
      241 igtaderilk phafyqvhri tgktvtttsy ekivgntkvl eiplepknnm ratidcagil
      301 klrnadielr kgetdigrkn trvrlvfrvh vpepsgrivs lqaasnpiec sqrsahelpm
      361 verqdmdscl vyggqqmilt gqnftaeskv vfmekttgpa gtcetrplpi slisadrlsp
      421 wlsrlqrnpp gsvfrcsvll papgsslvll al
//
LOCUS       NP_001394501             494 aa            linear   ROD 09-OCT-2023
DEFINITION  mitogen-activated protein kinase 10 isoform 7 [Mus musculus].
ACCESSION   NP_001394501
VERSION     NP_001394501.1
DBSOURCE    REFSEQ: accession NM_001407572.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 494)
  AUTHORS   Priego M, Noriega L, Kalinin S, Hoffman LM, Feinstein DL and
            Morfini G.
  TITLE     Genetic deletion of c-Jun amino-terminal kinase 3 (JNK3) modestly
            increases disease severity in a mouse model of multiple sclerosis
  JOURNAL   J Neuroimmunol 382, 578152 (2023)
   PUBMED   37454525
  REMARK    GeneRIF: Genetic deletion of c-Jun amino-terminal kinase 3 (JNK3)
            modestly increases disease severity in a mouse model of multiple
            sclerosis.
REFERENCE   2  (residues 1 to 494)
  AUTHORS   Liu F, Deng Y, Zhao Y, Li Z, Gao J, Zhang Y, Yang X, Liu Y and Xia
            Y.
  TITLE     Time series RNA-seq analysis identifies MAPK10 as a critical gene
            in diabetes mellitus-induced atrial fibrillation in mice
  JOURNAL   J Mol Cell Cardiol 168, 70-82 (2022)
   PUBMED   35489387
  REMARK    GeneRIF: Time series RNA-seq analysis identifies MAPK10 as a
            critical gene in diabetes mellitus-induced atrial fibrillation in
            mice.
REFERENCE   3  (residues 1 to 494)
  AUTHORS   Cunningham JG, Scripter JD, Nti SA and Tucker ES.
  TITLE     Early construction of the thalamocortical axon pathway requires
            c-Jun N-terminal kinase signaling within the ventral forebrain
  JOURNAL   Dev Dyn 251 (3), 459-480 (2022)
   PUBMED   34494344
REFERENCE   4  (residues 1 to 494)
  AUTHORS   Goodwani S, Fernandez C, Acton PJ, Buggia-Prevot V, McReynolds ML,
            Ma J, Hu CH, Hamby ME, Jiang Y, Le K, Soth MJ, Jones P and Ray WJ.
  TITLE     Dual Leucine Zipper Kinase Is Constitutively Active in the Adult
            Mouse Brain and Has Both Stress-Induced and Homeostatic Functions
  JOURNAL   Int J Mol Sci 21 (14), 4849 (2020)
   PUBMED   32659913
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 494)
  AUTHORS   Loughran G, Chou MY, Ivanov IP, Jungreis I, Kellis M, Kiran AM,
            Baranov PV and Atkins JF.
  TITLE     Evidence of efficient stop codon readthrough in four mammalian
            genes
  JOURNAL   Nucleic Acids Res 42 (14), 8928-8938 (2014)
   PUBMED   25013167
REFERENCE   6  (residues 1 to 494)
  AUTHORS   Beier H and Grimm M.
  TITLE     Misreading of termination codons in eukaryotes by natural nonsense
            suppressor tRNAs
  JOURNAL   Nucleic Acids Res 29 (23), 4767-4782 (2001)
   PUBMED   11726686
  REMARK    Review article
REFERENCE   7  (residues 1 to 494)
  AUTHORS   Yang DD, Kuan CY, Whitmarsh AJ, Rincon M, Zheng TS, Davis RJ, Rakic
            P and Flavell RA.
  TITLE     Absence of excitotoxicity-induced apoptosis in the hippocampus of
            mice lacking the Jnk3 gene
  JOURNAL   Nature 389 (6653), 865-870 (1997)
   PUBMED   9349820
REFERENCE   8  (residues 1 to 494)
  AUTHORS   Casanova E, Garate C, Ovalle S, Calvo P and Chinchetru MA.
  TITLE     Identification of four splice variants of the mouse
            stress-activated protein kinase JNK/SAPK alpha-isoform
  JOURNAL   Neuroreport 7 (7), 1320-1324 (1996)
   PUBMED   8817558
REFERENCE   9  (residues 1 to 494)
  AUTHORS   Martin JH, Mohit AA and Miller CA.
  TITLE     Developmental expression in the mouse nervous system of the p493F12
            SAP kinase
  JOURNAL   Brain Res Mol Brain Res 35 (1-2), 47-57 (1996)
   PUBMED   8717339
REFERENCE   10 (residues 1 to 494)
  AUTHORS   Suzuki J, Yoshida S, Chen ZL, Momota Y, Kato K, Hirata A and
            Shiosaka S.
  TITLE     Ontogeny of neuropsin mRNA expression in the mouse brain
  JOURNAL   Neurosci Res 23 (4), 345-351 (1995)
   PUBMED   8602273
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC123664.15, AC137121.9 and
            AC125252.7.
            
            Summary: The protein encoded by this gene is a member of the MAP
            kinase family. MAP kinases act as integration points for multiple
            biochemical signals, and thus are involved in a wide variety of
            cellular processes, such as proliferation, differentiation,
            transcription regulation and development. This kinase is
            specifically expressed in a subset of neurons in the nervous system
            and is activated by threonine and tyrosine phosphorylation.
            Targeted deletion of this gene in mice suggests that it may have a
            role in stress-induced neuronal apoptosis. Alternatively spliced
            transcript variants encoding different isoforms have been found for
            this gene. A recent study provided evidence for translational
            readthrough in this gene, and expression of an additional
            C-terminally extended isoform via the use of an alternative
            in-frame translation termination codon. [provided by RefSeq, Dec
            2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK042368.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..494
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 49.61 cM"
     Protein         1..494
                     /product="mitogen-activated protein kinase 10 isoform 7"
                     /EC_number="2.7.11.24"
                     /note="JNK3 beta1 protein kinase; JNK3 beta2 protein
                     kinase; MAP kinase 10; MAP kinase p49 3F12; c-Jun
                     N-terminal kinase 3; stress-activated protein kinase JNK3;
                     SAPK/Erk/kinase 2"
                     /calculated_mol_wt=55583
     Region          93..428
                     /region_name="STKc_JNK"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     c-Jun N-terminal Kinase; cd07850"
                     /db_xref="CDD:270840"
     Site            order(100..106,108,121,123,140,154,176..182,184..185,219,
                     221,223..224,226,236..237,240,251,253..256,258,295)
                     /site_type="active"
                     /db_xref="CDD:270840"
     Site            order(100..106,108,121,123,154,176..182,226,236)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270840"
     Site            order(140,184,219,221,240,251,253..256,258,295)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270840"
     Site            order(180,186,195,198,227..231,391..392,394,397)
                     /site_type="other"
                     /note="KIM docking site [polypeptide binding]"
                     /db_xref="CDD:270840"
     Site            order(236..246,250..258)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270840"
     CDS             1..494
                     /gene="Mapk10"
                     /gene_synonym="C230008H04Rik; JNK3; JNK3B1; JNK3B2;
                     p493F12; p54bSAPK; SAPK(beta); Serk2"
                     /coded_by="NM_001407572.1:43..1527"
                     /note="isoform 7 is encoded by transcript variant 7"
                     /db_xref="GeneID:26414"
                     /db_xref="MGI:MGI:1346863"
ORIGIN      
        1 mgdtgvsgap mkemaqvmri aevtedgrvf mslhflyycs eptldvkiaf cqgfdkhvdv
       61 ssiakhynms kskvdnqfys vevgdstftv lkryqnlkpi gsgaqgivca aydavldrnv
      121 aikklsrpfq nqthakrayr elvlmkcvnh kniisllnvf tpqktleefq dvylvmelmd
      181 anlcqviqme ldhermsyll yqmlcgikhl hsagiihrdl kpsnivvksd ctlkildfgl
      241 artagtsfmm tpyvvtryyr apevilgmgy kenvdiwsvg cimgemvrhk ilfpgrdyid
      301 qwnkvieqlg tpcpefmkkl qptvrnyven rpkyagltfp klfpdslfpa dsehnklkas
      361 qardllskml vidpakrisv ddalqhpyin vwydpaevea pppqiydkql derehtieew
      421 keliykevmn seektkngvv kgqpspsgaa vnsseslpps ssvndissms tdqtlasdtd
      481 ssleasagpl gccr
//