==== Front Int J Appl Basic Med ResInt J Appl Basic Med ResIJABMRInternational Journal of Applied and Basic Medical Research2229-516X2248-9606Medknow Publications & Media Pvt Ltd India 30123755IJABMR-8-19610.4103/ijabmr.IJABMR_366_17Case ReportFailure of Eruption of Permanent Tooth Bhuvaneswarri J Chandrasekaran SC Department of Periodontology, Sree Balaji Dental College and Hospital, Pallikaranai, Chennai, Tamil Nadu, IndiaAddress for correspondence: Dr. J Bhuvaneswarri, Reader, Department of Periodontics and Implantology, Sree Balaji Dental College, Pallikaranai, Chennai - 600 100, Tamil Nadu, India. E-mail: drbhuvana22@gmail.comJul-Sep 2018 8 3 196 198 24 10 2017 25 6 2018 Copyright: © 2018 International Journal of Applied and Basic Medical Research2018This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.Primary failure of eruption (PFE) is a rare condition that can lead to posterior open bites. It is difficult to diagnose and difficult to treat. PFE appears to be a condition that predominantly affects the molar dentition. The increased frequency of hypodontia in affected individuals and common findings of a family history regarding tooth eruption problems suggests a significant genetic component to the etiology of this rare condition. Keywords: Eruption failureprimary tooth failureretained teeth ==== Body Introduction Tooth eruption has been defined as the movement of a tooth from its site of development within the alveolar process to its functional position in the oral cavity. It is a localized process in the jaws that exhibits precise timing and bilateral symmetry. The dental follicle is necessary for the coordinated resorption and deposition of bone on opposite sides of the erupting tooth during intraosseous tooth eruption. The absence of a tooth in the oral cavity may be the result of some interference with the process of tooth eruption. Most commonly, local factors causing mechanical obstruction to tooth movement into the oral cavity are responsible for the failure of tooth eruption.[12] Primary retention is defined as a cessation of tooth eruption before emergence that is not due to a physical barrier in the eruption path, does not result from an abnormal position, and has no systemic cause. A review of the literature suggests that primary retention of permanent teeth is rare, has not been reported in all four quadrants, and has not been associated with abnormalities of the eruption of the primary teeth.[345] This report describes a female patient with primary retention in the deciduous dentition and the permanent dentition. Case Report A 16 year old female patient appeared for the evaluation and treatment at our clinic with a history of retained primary teeth. The patient's medical history revealed that Her mother had an uneventful pregnancy and was delivered at 38 weeks by normal delivery. A panoramic radiograph revealed the presence of retained primary teeth and development of few permanent teeth. At that time, an extensive evaluation showed no abnormalities in thyroid function, and calcium, phosphorus, and alkaline phosphatase levels were within the normal range for a growing age. Bone age corresponded to chronologic age. The patient has continued to grow normally throughout childhood; for her age, she is above normal in height and weight. The general health of the patient has been excellent, with no allergies or hospitalizations. She has a male sibling with no dental problems, and there is a negative family history of dental anomalies. Physical evaluation revealed her to be a well-proportioned girl with no craniofacial, dermal, or skeletal morphologies. She displayed age-appropriate development, and no abnormalities were noted in her hair, skin, or nails. On initial examination at 16 years of age, it was noted that 16 of her permanent teeth had erupted; these teeth displayed normal size, shape, and quality of enamel; 14 of her primary teeth are retained [Figures 1 and 2]. Radiographically, retained primary teeth were present, and few permanent teeth impacted [Figure 3]. The nonerupted teeth were covered with bone and had well-circumscribed follicles. However, continued root development of the permanent teeth was noted, without progress toward the alveolar crest. Figure 1 Unerupted permanent teeth facial view Figure 2 Unerupted permanent teeth occlusal view Figure 3 Radiograph showing retained permanent teeth The patient was evaluated extensively at the initial visit and subsequent visits. All laboratory values were within the normal range, including parathyroid, thyroid, and growth hormone levels and calcium, phosphorus, and vitamin D levels. Bone age at 16 years corresponded to chronologic age. In the absence of any other signs, the diagnosis was primary retention of the permanent teeth. Discussion This case describes a generalized failure or delay in all tooth types in both the dentition. Delayed eruption is a feature of many diseases and syndromes. The patient was growing at a normal rate, was within normal limits concerning facial and skeletal growth, and was of normal intelligence. No underlying systemic abnormalities have been detected. Disorders of tooth eruption can be difficult to diagnose given the lack of knowledge about the eruptive process. The diagnosis is based on clinical and radiographic characteristics and sometimes on the response to treatment. The treatment goals are to encourage the teeth to erupt into the oral cavity, usually through surgical exposure.[678] Many possible syndromes were eliminated because of a lack of associated signs and the lack of any familial tendency. Gardner syndrome is another autosomal dominant disorder associated with failure of eruption of the permanent teeth. There was no family history of the disorder, and once again, a defect in eruption of the primary dentition has not been reported in this syndrome. Ankylosis can occur at any stage during the eruption and can sometimes be diagnosed radiographically by the absence of the periodontal ligament space. The diagnosis is usually based on clinical findings and can be difficult if the teeth have not penetrated the oral mucosa. Ankylosis occurs in the primary and permanent dentitions, most commonly in the primary molar region and in all four quadrants.[91011] Generalized ankylosis, affecting all tooth types and in both dentitions, has not been reported previously. A diagnosis of primary retention, idiopathic failure of eruption, or embedded teeth is a diagnosis and cannot be separated from ankylosis when there is no eruption of teeth into the oral cavity. There have been many reports of idiopathic failure of permanent tooth eruption. In each case, there were no abnormalities in the eruption of the deciduous dentition, and only single-tooth types were affected, usually molars. There have been no reports in the literature of generalized primary retention of primary and permanent teeth in the same patient. Primary retention of primary and permanent teeth could be due to a defect in the dental follicle causing disturbed local metabolism and interference with the biological interactions necessary for the eruptive process. Research on mechanisms of tooth eruption has been reviewed by Marks et al. They define tooth eruption as a localized, symmetric process of bone resorption and deposition that is dependent on interaction with the dental follicle and is regulated by a number of biological mediators, such as epidermal growth factor, interleukin, nuclear matrix-intermediate filament, and matrix metalloproteinases. To date, however, the interactions of these mediators have been studied only in animal models. It has also been proposed that each tooth has a “window of opportunity” for successful eruption and that defects during this critical time will cause interference in the eruptive process.[12131415] Conclusion This case represents a unique clinical situation and appears to reflect a severe generalized disturbance in the eruptive process, a generalized primary retention, or idiopathic failure of tooth eruption. Evidence from the current literature would suggest that this disorder has a substantial genetic component.[141516] Declaration of patient consent The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed. Financial support and sponsorship Nil. 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