==== Front Ann Saudi MedAnn Saudi MedAnnals of Saudi Medicine0256-49470975-4466King Faisal Specialist Hospital and Research Centre 2270561810.5144/0256-4947.2012.427asm-4-427Case ReportRevisiting fetus-in-fetu Gude Dilip aRayudu Batta Ramasubba bBansal Dharam cSashidhar Chennamsetty d a Department of Internal Medicine, Medwin Hospital, Nampally, Hyderabad, Andhra Pradesh, India b Department of Radiology, Medwin Hospital, Nampally, Hyderabad, Andhra Pradesh, India c Department of Pulmonology and Critical Care, Medwin Hospital, Nampally, Hyderabad, Andhra Pradesh, India d Department of Nephrology, Medwin Hospital, Nampally, Hyderabad, Andhra Pradesh, IndiaCorrespondence: Dilip Gude, Acute Medical Care, 3rd Floor, Medwin Hospital, Chirag Ali Lane, Nampally, Hyderabad, Andhra Pradesh 500 001, India, T: 091-9985445947, F: 091-40-23201120, letsgo.dilip@gmail.comJul-Aug 2012 32 4 427 429 Copyright © 2012, Annals of Saudi Medicine2012This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.Fetus-in-fetu is a rare congenital anomaly in which a malformed parasitic twin is found within the body of its partner. Less than 100 cases have been reported in published studies. Although it is a relatively benign condition, clinicians need to have a high index of suspicion for the associated complications that may arise. We report the case of an infant presenting with jaundice and steadily growing abdominal mass, who was diagnosed with fetus-in-fetu syndrome. We review the published studies and discuss the pathophysiology, complexities, and management options. ==== Body Fetus-in-fetu is an extremely uncommon cause of abdominal mass in the neonate, presenting as an encapsulated and pedunculated vertebrate fetoid mass in the abdomen usually from birth.1 Less than 100 cases have been reported in the published studies. There is a male preponderance (male: female 2:1),2 and about two-thirds of the cases present before 2 years of age. The presence of such an entity may lead to various manifestations secondary to mass effect on the adjacent viscera (obstructive jaundice in our case). We report a case of an infant presenting with mass abdomen and jaundice, and on evaluation was found to be fetus-in-fetu. We review the published studies and attempt to throw light on the possible pathophysiologic mechanisms, the manifestations, and management. CASE We report a case, in retrospect (1974), of an 11-month-old infant who presented with mass abdomen, failure to thrive, recurrent vomiting, and jaundice from about 4 months of age. He was a product of a non-consanguineous marriage and was born full term by normal spontaneous vaginal delivery. The abdominal mass had been steadily increasing in size with progressive worsening of the associated symptoms. The weight of the baby was 7.8 kg. The examination revealed icterus and mild pallor. Vital signs were unremarkable. The abdominal exam revealed an irregular mass on palpation, spanning from the left hypochondrium to the iliac fossa, and multiple irregular, firm to bony masses palpable all over the abdomen. A plain abdominal x-ray taken in 1974 showed multiple calcific/ossific densities on either side of the abdomen with evidence of long bones of limbs (Figure 1). (Further investigations like computed tomography (CT) and ultrasonography (USG) were not available at that time). The intravenous pyelogram depicted good excretion on both sides, showing a normal collecting system on the left side with evidence of hydronephrosis and upward and lateral displacement of the right kidney by the calcific/ossific density mass. The patient’s liver function tests were deranged (total bilirubin 5.3 mg/dL [normal 0.3 to 1.9 mg/dL], direct bilirubin 3.8 mg/dL [normal 0 to 0.3 mg/dL], alkaline phosphatase 385 U/L [normal 45–125 U/L]). Other lab tests were essentially normal. The surgical evacuation of the mass grossly showed features of a fetus having upper and lower limbs with anencephaly. Radiographs of the specimen further delineated the fetus’s spine (broken arrow in Figures 2 and 3), upper and lower limbs (thin arrows in Figures 2 and 3), and evidence of anencephaly (thick arrow in Figures 2 and 3). On follow-up after 2 weeks, the patient’s jaundice significantly improved and he was doing well. DISCUSSION Fetus-in-fetu is hypothesized to result from an unequal division of the totipotential inner cell mass of the developing blastocyst, leading to the inclusion of a smaller cell mass within a maturing sister embryo.3 The aborted or suppressed monozygotic twin (monoamniotic, monochorionic) later develops vitelline circulation anastomoses4 ultimately resulting in partial or complete external morphologic characteristics of a human form. Although a single fetus-in-fetu is the usual presentation, there have been reports of 2,5 3,6 57 or more fetuses in the published studies. The vascular dominance of the host twin or, at times, an inherent defect in the parasitic twin will hamper the growth of the fetus-in-fetu which, initially in utero, parallels that of the host twin. Although an accurate preoperative diagnosis is not difficult most of the time, in some cases only a laparotomy can clinch the diagnosis. The diagnosis in our case was especially difficult, given the paucity of investigations at that time (1974). It is mostly found in the retroperitoneum, but has also been reported to occur in the cranial cavity,8 lateral ventricles, scrotum,8 testicles,9 pelvis,6 iliac mesentery,10 adrenal, coccyx,11 and inguinal region.12 The symptoms (from the mass effect) usually are abdominal distention, difficulty in feeding, vomiting, jaundice, and urinary retention. Differentiating from the much more frequent, highly organized, and well-differentiated teratoma, which is a true tumor with a distinct malignant potential, is of paramount importance as the prognostic implications vary drastically. Grossly, the amniotic-like sac appearance, fine hair-bearing skin covering the whole specimen, and vestigial limbs or organs appropriately arranged with respect to the vertebral axis help in distinguishing it from a teratoma. Most authors opine that the presence of a vertebral column/neural tube, an amnion or umbilical cord, tissue indigenous to an embryo/fetus, and a high degree of structural organization (organoaxial orientation) differentiates the entity from teratomas. There are reports of “pseudofetu” or a sacrococcygeal teratoma without a verebral column, but with rudimentary organs and other such presentations that argue the possibility of an overlap or entities representing the same pathology at different stages of maturation (about 9% of the cases do not have a well-defined vertebral axis). There have been case reports of a fetus-in-fetu and a teratoma occurring in the same patient reinforcing such theories. Both these entities may present with different degrees of spinal dysgenesis or residual posterior enteric remnants secondary to early focal disturbance of endodermal-ectodermal differentiation.13 The other differentials include Wilm tumor, neuroblastoma, and hydronephrotic kidney. Almost every organ in fetus-in fetu is deformed due to hypoxia, with anencephaly being common. Although the body is closed most of the time, ventral defects, like omphalocele, are not uncommon.7 Usually, the host does not manifest with any anomalies other than those related to the presence of a space-occupying lesion. Malignant degeneration has never been reported and appears highly unlikely. Saponification and skeletonization of fetuses, as occurs in a longstanding abdominal pregnancy, have not been described in cases of fetus-in-fetu for mechanisms that are unclear.14 USG commonly shows a well-delineated capsule, with an echogenic mass suspended/partially surrounded in fluid and occasionally a rudimentary spine.15 CT and other imaging modalities may better delineate the long bones, spine, and appendages of the mass. Treatment includes excision of the fetus with its capsule, and usually the mass is easily removed from the loosely adherent adjacent structures. The complete excision curbs the problems associated with increasing size, local pressure, hemorrhage into cystic mass, and uncertainty about diagnosis. The outcome is generally excellent. The child needs to be adequately followed up. Fetus-in-fetu is a very rare entity, but warrants a place in the differential diagnoses of abdominal mass in a child. Although mostly benign, the possible co-occurrence of a teratoma mandates surgical removal of the mass and the prognosis is mostly good. Figure 1 Plain abdominal x-ray showing multiple calcific/ossific densities on either side of the abdomen with evidence of long bones of limbs. Figure 2 Radiograph of the specimen (post operative) delineating the fetus’s spine (broken arrow), upper and lower limbs (thin arrows) with evidence of anencephaly (thick arrow). Figure 3 Post-operative radiograph of the specimen confirming Fetus-in-fetu disorder with evidence of spine (broken arrow), upper and lower limbs (thin arrows) and anencephaly (thick arrow). ==== Refs REFERENCES 1 Mohta A Shrivastava UK Sodhi P Upreti L Fetus in fetu: A case report Pediatr Surg Int 2003 19 499 500 12783257 2 Hoeffel CC Nguyen KQ Phan HT Truong NH Nguyen TS Tran TT Fetus in fetu: A case report and literature review Pediatrics 2000 105 1335 44 10835078 3 Boyce MJ Lockyer JW Wood CB Foetus in foetu. 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