==== Front Indian J OphthalmolIndian J OphthalmolIJOIndian Journal of Ophthalmology0301-47381998-3689Medknow Publications & Media Pvt Ltd India 30038171IJO-66-118310.4103/ijo.IJO_606_18CommentaryCommentary: Smoke stack leak on indocyanine green angiography in acute central serous chorioretinopathy Mishra Chitaranjan Department of Vitreo-Retinal Services, Aravind Eye Hospital, Anna Nagar, Madurai, Tamil Nadu, India Correspondence to: Dr. Chitaranjan Mishra, Department of Vitreo-Retinal Services, Aravind Eye Hospital, Anna Nagar, Madurai - 625 020, Tamil Nadu, India. E-mail: drchitaranjan.gnec@gmail.com8 2018 66 8 1183 1183 Copyright: © 2018 Indian Journal of Ophthalmology2018This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.Smokestack leak on indocyanine green angiography in acute central serous chorioretinopathy ==== Body The pathophysiology of central serous chorioretinopathy (CSCR) involves multiple mechanisms that ultimately lead to widespread choroidal circulatory abnormalities and subsequent retinal pigment epithelial (RPE) disturbances. Angiography of retinochoroidal vascular system is very important in the diagnosis and management of CSCR. Smoke stack leakage (SSL) is an important finding in fluorescein angiography (FA) of CSCR cases, the mechanism of which can be explained by an increased concentration of protein in the subretinal fluid. However, indocyanin green angiography (ICGA) does not typically show SSL in acute CSCR. The work by Ayachit et al.[1] is appreciated for the documentation of a rare finding, i.e., SSL in ICGA in acute CSCR cases. The explanations for the finding given by them, e.g., possible presence of an RPE microrip or vigorous leakage from choriocapillaris is well taken and supported by literature. The phenomena of RPE microrip or RPE blow out was explained by Goldstein et al.[2] However, it is noteworthy that this is not the first report of its kind as claimed by the authors. Piccolino et al. has demonstrated the smoke stack appearance in ICGA in acute CSCR.[3] Spectral domain OCT imaging helps to identify RPE microrip. There have been mentions about other possible mechanisms for hyperpermeability and leakage in chronic CSCR in recent literature, some of which can be pondered in cases of CSCR who are presenting early. Prakash et al. has mentioned about occult PEDs.[4] Teussink et al. have mentioned about the role of reduced blood perfusion and ischemia in the choriocapilaries, demonstrated in OCTA, which may be surrounded by reactive hyperperfusion which leads to increased hydrostatic pressure within the fenestrated choriocapillaris.[5] This along with chronic hypoxic damage may lead to disintegrity in the continuity of RPE leading to leakage of subretinal fluid. There has been mention about RPE degeneration by Hyashi et al.[6] Hypoperfusion and vasodilation of choriocapillaries has been mentioned by Gajdecka et al.[7] There are recent publications regarding choroidal vascularity index in CSCR, which may throw some light on the exact mechanism of this rare finding.[8] Finally, SSL in ICGA in acute CSCR is a rare finding and its documentation and discussion about possible mechanisms among peer group enriches the collective academical knowledge. ==== Refs 1 Ayachit A Kumar V Raj N Ayachit G Smokestack leak on indocyanine green angiography in acute central serous chorioretinopathy Indian J Ophthalmol 2018 66 1181 2 30038170 2 Goldstein BG Pavan PR 'Blow-outs’ in the retinal pigment epithelium Br J Ophthalmol 1987 71 676 81 Erratum in: Br J Ophthalmol 1988;72:240 3484371 3 Piccolino FC Borgia L Zinicola E Zingirian M Indocyanine green angiographic findings in central serous chorioretinopathy Eye (Lond) 1995 9 324 32 7556741 4 Prakash G Chauhan N Jain S Satsangi SK Central Serous Chorioretinopathy: A Review of the Literature Asia Pac J Ophthalmol (Phila) 2013 2 104 10 26108047 5 Teussink MM Breukink MB van Grinsven MJ Hoyng CB Klevering BJ Boon CJ OCT Angiography Compared to Fluorescein and Indocyanine Green Angiography in Chronic Central Serous Chorioretinopathy Invest Ophthalmol Vis Sci 2015 56 5229 37 26244299 6 Hayashi K Hasegawa Y Tokoro T Indocyanine green angiography of central serous chorioretinopathy Int Ophthalmol 1986 9 37 41 3721709 7 Gajdzik-Gajdecka U Dorecka M Nita E Michalska A Miniewicz-Kurowska J Romaniuk W Indocyanine green angiography in chronic central serous chorioretinopathy Med Sci Monit 2012 18 CR51 7 22293877 8 Agrawal R Chhablani J Tan KA Shah S Sarvaiya C Banker A Choroidal vascularity index in central serious chorioretinopathy Retina 2016 36 1646 51 27124882