==== Front Indian J OphthalmolIndian J OphthalmolIJOIndian Journal of Ophthalmology0301-47381998-3689Medknow Publications & Media Pvt Ltd India IJO-66-123110.4103/ijo.IJO_814_18Letters to the EditorResponse to comment on: A rare case of unilateral diffuse uveal melanocytic proliferation Ayachit Guruprasad Ayachit Apoorva Joshi Shrinivas Sameera V V Department of Vitreoretina, M. M. Joshi Eye Hospital, Hubballi, Karnataka, India Correspondence to: Dr. Apoorva Ayachit, M. M. Joshi Eye Hospital, Gokul Road, Hosur, Hubballi - 580 021, Karnataka, India. E-mail: apoorva.ag@gmail.com8 2018 66 8 1231 1231 Copyright: © 2018 Indian Journal of Ophthalmology2018This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. ==== Body Sir, We thank Dogra et al. for their keen interest and astute reading of our article.[1] Like we mentioned in our report, the breast lesion was excised completely. Hence, monitoring the reduction in size of the breast lesion was not an option. The patient awaits a follow-up positron emission tomography scan as advised by the treating oncologist. Every treatment for diffuse uveal melanocytic proliferation (DUMP) has to include concurrent treatment for primary malignancy. Hence, it is difficult to attribute the resolution of fluid to any of the proposed treatments for DUMP alone; be it steroids, plasmapheresis, and periocular or intravitreal treatment.[2] Our case was a diagnostic dilemma in the beginning because there were choroidal elevations and extensive subretinal fluid, and the presentation was unilateral. Choroidal metastasis was an important differential. This was the reason we considered administering intravitreal bevacizumab (IVB) in the first place. It was a serendipitous discovery that IVB showed a reduction in fluid in this case (later diagnosed as DUMP because of its typical imaging features described in detail in our original article) along with symptomatic relief. Periocular steroid has also been used by another study group for DUMP with partial success. They had to repeat the injection after 5 months.[3] It is unclear why DUMP has serous retinal detachments. Theories such as blood–retinal barrier breakdown (because of toxic or immunological products) and relative hypoxia because of hypermetabolic retinal pigment epithelium have been proposed. We hypothesize that similar to periocular steroids, bevacizumab helps ameliorate subretinal fluid due to its anti-permeability effects.[45] It will be interesting to see if more cases of DUMP get successfully treated with bevacizumab to confirm or refute our hypothesis. Financial support and sponsorship Nil. Conflicts of interest There are no conflicts of interest. Acknowledgments The authors wish to thank Dr. Kiran Kulkarni MD (Radiodiagnosis) for help provided in the radiologic workup of this patient. ==== Refs 1 Dogra M Singh SR Singh R Dogra MR Comment on: A rare case of unilateral diffuse melanocytic proliferation Indian J Ophthalmol 2018 66 1230 30038196 2 Jansen JC Van Calster J Pulido JS Miles SL Vile RG Van Bergen T Early diagnosis and successful treatment of paraneoplastic melanocytic proliferation Br J Ophthalmol 2015 99 943 8 25908835 3 Joseph A Rahimy E Sarraf D Bilateral diffuse uveal melanocytic proliferation with multiple iris cysts JAMA Ophthalmol 2014 132 756 60 24763691 4 Chahud F Young RH Remulla JF Khadem JJ Dryja TP Bilateral diffuse uveal melanocytic proliferation associated with extraocular cancers: Review of a process particularly associated with gynecologic cancers Am J Surg Pathol 2001 25 212 8 11176070 5 O'Neal KD Butnor KJ Perkinson KR Proia AD Bilateral diffuse uveal melanocytic proliferation associated with pancreatic carcinoma: A case report and literature review of this paraneoplastic syndrome Surv Ophthalmol 2003 48 613 25 14609707