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J Adv Pharm Technol ResJ Adv Pharm Technol ResJAPTRJournal of Advanced Pharmaceutical Technology & Research2231-40400976-2094Medknow Publications & Media Pvt Ltd India JAPTR-9-4310.4103/japtr.JAPTR_236_18EditorialPharmaceutical applications of liquisolid technique Nagaich Upendra Dr.Editor, Journal of Advanced Pharmaceutical, Technology and Research, Editor-in-Chief, SPER Times, Secretary, Society of Pharmaceutical Education and Research, 22-C, Jawahar Colony, Gwalior - 474 001, Madhya Pradesh, India. E-mail: editor@japtr.orgApr-Jun 2018 9 2 43 43 Copyright: © 2018 Journal of Advanced Pharmaceutical Technology & Research2018This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
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The majority of recently discovered active moieties are poorly water-soluble and hydrophobic in nature. Therefore, a big challenge for dissolution and bioavailability enhancement of these drugs had developed. Liquisolid technique is a novel approach toward the development of dry, nonadherent, free-flowing, and compressible powder from the drug in liquid state. Merits of this approach include low costing, simple processing for the formulation of oily liquid drugs, great potentials in industrial production, possess enhanced in vitro drug release as compared to capsules dosage form. Furthermore, it also retards the drug release, i.e., sustained or controlled release can be effectively achieved. The concept behind this approach is adsorption and absorption both. When drug dissolved in liquid carrier is poured onto a porous carrier material, liquid gets absorbed in its internal structure, and after saturation, adsorption on external surface occurs. The porous material having high adsorptive properties gives desirable flow characteristics to the liquisolid system. Moreover, this technique has been explored as an instrument to reduce the pH variation effect on drug release. Liquisolid technique has been classified on the basis of liquid active moieties, viz., powdered drug solutions, powdered drug suspensions, and powdered liquid drugs, and on the basis of formulation technique, viz., liquisolid compacts and liquisolid microsystems. There are numerous applications, viz., enhancement of bioavailability of water-insoluble drugs, sustained and rapid release formulations, and improvement in solubility and dissolution, flowability, and compressibility.