==== Front Ann Saudi MedAnn Saudi MedAnnals of Saudi Medicine0256-49470975-4466King Faisal Specialist Hospital and Research Centre 10.5144/0256-4947.2014.556asm-6-556LetterKounis syndrome and antibiotics Biteker Funda Sungur aDogan Volkan bMert Kadir Ugur bMert Gurbet Ozge bBiteker Murat b a Department of Infectious Diseases and Clinical Microbiology, Mugla Sitki Kocman University, Mugla, Turkey b Department of Cardiology, Mugla Sitki Kocman University, Mugla, TurkeyCorrespondence: Dr. Murat Biteker, Department of Cardiology, Mugla Sitki Kocman University, Mugla 74775, Turkey, T: +90 252 214 13 26, F: +90 252 2111345, murbit2@yahoo.comNov-Dec 2014 34 6 556 556 Copyright © 2014, Annals of Saudi Medicine2014This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. ==== Body To the Editor: We read with interest the article recently published by Saleh entitled “Kounis syndrome: acute inferior myocardial infarction with atroventricular node block due to ceftriaxone: a first reported case.”1 However, we have some concerns about the article. Inflammatory mediators, adhesion molecules of neutrophils, and monocytes have been shown to be increased in the plasma of patients presenting with acute coronary syndromes. Anaphylaxis is a systemic, immediate hypersensitivity reaction caused by rapid, immunoglobulin (Ig) E-mediated release of mediators from mast cells and basophils. Kounis syndrome (KS) is the coincidental occurrence of these two distinct conditions accompanied by clinical and laboratory findings of angina pectoris caused by inflammatory mediators released during an allergic insult.2 Allergic angina can progress to acute myocardial infarction, which is named ”allergic myocardial infarction.” Three variants of KS have been described.3 The type I variant (coronary spasm), which might represent a manifestation of endothelial dysfunction or microvascular angina, includes patients with normal coronary arteries without predisposing factors for the coronary artery disease. In these patients, the acute release of inflammatory mediators can induce either coronary artery spasm without increase of cardiac enzymes and troponins or coronary artery spasm progressing to acute myocardial infarction with raised cardiac enzymes and troponins. The type II variant (coronary thrombosis) includes patients with culprite but quiescent pre-existing atheromatous disease. In these patients, the acute release of inflammatory mediators can induce either coronary artery spasm with normal cardiac enzymes and troponins, plaque erosion, or rupture manifesting as acute myocardial infarction. The type III variant (drug-eluting stent thrombosis) includes patients with stent thrombosis. In these patients, thrombus harvesting and staining with hematoxylin–eosin and Giemsa shows the presence of eosinophils and mast cells, respectively. Although Saleh claimed the current patient as the first KS patient associated with ceftriaxone use, this is not true. Çaglar et al described an 85-year-old woman with ST-segment elevations on the anterior precordial leads after the use of ceftriaxone.4 Yurtda and Aydin also repoted a 42-year-old man with no history of known atopy or cardiovascular risk factors presented the emergency department with the chest pain, severe dyspnea, sweatings, nausea, vomitting and, urticarial and edematous lesions approximately 20 minutes after the use of ceftriaxone.5 Electrocardiogram was compatible with acute inferior myocardial infarction. There are several causes that have been reported as capable of inducing KS.6 These include a number of conditions, several drugs, foods, insect stings, etc.6,7 After the first report of allergic myocardial infarction, nearly 350 cases with KS have been reported in the published studies. In summary, in the investigation or interpretation of the published studies, authors should be careful and reviewers must be qualified to evaluate a component of the research. ==== Refs REFERENCES 1 Saleh AA Kounis syndrome: acute inferior myocardial infarction with atroventricular node block due to ceftriaxone: a first reported case Ann Saudi Med 2014 May-Jun 34 3 250 3 10.5144/0256-4947.2014.250 25266187 2 Biteker M Current understanding of Kounis syndrome Expert Rev Clin Immunol 2010 6 5 777 88 20828286 3 Biteker M A new classification of Kounis syndrome Int J Cardiol 2010 145 3 553 20542582 4 Çaglar FN Çaglar IM Coskun U Ugurlucan M Okcun B Kounis syndrome: myocardial infarction secondary to an allergic insult--a rare clinical entity Acta Cardiol 2011 66 4 559 62 21894822 5 Yurtdaç M Aydin MK A case of coronary spasm with resultant acute myocardial infarction: likely the result of an allergic reaction Intern Med 2012 51 16 2161 4 22892496 6 Biteker M Duran NE Biteker F Kounis syndrome: first series in Turkish patients Anadolu Kardiyol Derg 2009 9 1 59 60 19196576 7 Biteker M Duran NE Biteker FS Kounis syndrome secondary to cefuroxime-axetil use in an octogenarian J Am Geriatr Soc 2008 56 9 1757 8 19166448