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Ann Saudi MedAnn Saudi MedAnnals of Saudi Medicine0256-49470975-4466King Faisal Specialist Hospital and Research Centre 1901131510.5144/0256-4947.2008.476asm-6-476ImagesNeck swelling secondary to severe hyperplasia of autotransplanted parathyroid tissue following parathyroidectomy Pavlovic Drasko aOrlic Lidija bTomic-Brzac Hrvojka cPavlovic Nikola dPetric Vlado e
a Department of Nephrology and Dialysis, Sestre Milosrdnice University Hospital, Croatia
b Department of Nephrology and Dialysis, University Hospital Rijeka, Croatia
c Department of Nuclear Medicine and Radiation, University Hospital Zagreb, Croatia
d Department of Medicine, Sestre Milosrdnice University Hospital, Croatia
e Ear, Nose, Throat and Neck Surgery, Sestre Milosrdnice University Hospital, CroatiaCorrespondence and reprints: Drasko Pavlovic MD, Department of Nephrology and Dialysis, Sestre Milosrdnice University Hospital, Vinogradslea c. 29 Zagreb 10000 Croatia, T: +3851-378-7526, F: +3851-376-9067, drasko.pavlovic@bol-svduh.htnet.hrNov-Dec 2008 28 6 476 477 01 6 2008 Copyright © 2008, Annals of Saudi Medicine2008This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
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Secondary hyperparathyroidism, characterized by an increase in the synthesis and secretion of parathyroid hormone (PTH) and parathyroid hyperplasia, is a very common complication of chronic kidney disease.1 Despite significant advances in medical therapy, in 5% to 10% of patients with chronic renal failure, parathyroidectomy (PTX) may be indicated.2,3 Unfortunately, recurrent or persistent hyperparathyroidism can be seen in up to 10% of patients after PTX.4,5 Our case was a 44-year-old women with recurrent hyperparathyroidism after total PTX with auto-transplantation into the sternocleidomastoid muscle, who presented with an enlarged neck structure. She had chronic renal failure due to chronic glomerulonephritis and was on hemodialysis. Four years later, total PTX with autotransplantation in a single area into the sternocleidomastoid muscle was performed. Seven years after the surgery, the intact PTH level was 2630 pg/mL (normal range, 6–62 pg/mL), and total alkaline phosphatase was 682 IU/L (normal range, 60–170 IU/L). The patient refused a new operation. Two years later an enlarged structure in the neck was observed (Figure 1). At that time, intact PTH was 2632 pg/mL and total alkaline phosphatase was 818 IU/L. By ultrasound, five enlarged structures suspected of having hyperplastic parathyroid tissue were found; a small one (dimension 0.9×0.9×0.8 cm) with uniform echoes and four larger ones with a nodular pattern of hyperplasia. The largest one, with dimensions of 2.5×1.3×2.2 cm was detected subcutaneously and by palpation, corresponding to the nearby enlarged structure, the left sternocleidomastoid muscle. We assumed that the largest nodule was a consequence of hyperplasia of the autotransplanted parathyroid tissue while the other hyperplastic nodules were a consequence of the scattered parathyroid cells. Proliferation of parathyroid cells was confirmed by fine needle biopsy of the largest nodule. Surgery was performed and all enlarged structures, i.e. parathyroid tissue, were removed (Figure 2). Histopathological examination showed nodular hyperplasia of parathyroid tissue, including the largest one (Figure 3), and diffuse hyperplasia of the smallest one. One month later, intact PTH was 374.2 pg/mL and total alkaline phosphatase did not change significantly (929 IU/L). Unfortunately, a year later her PTH was 656.4 pg/ mL and therapy with paricalcitol was started.

Figure 1 Enlarged neck structure, near the left sternocleidomastoid muscle.

Figure 2 Single large dissected autotransplanted parathyroid nodule.

Figure 3 Parathyroid nodular hyperplasia dispersed between muscle cells (hematoxylineosin ×40).
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