==== Front Korean Circ JKorean Circ JKCJKorean Circulation Journal1738-55201738-5555The Korean Society of Cardiology 3007381110.4070/kcj.2018.0118EditorialThe Transradial Approach for Coronary Intervention: More Comfort, Better Outcome https://orcid.org/0000-0003-3987-2159Lee Cheol Whan MDhttps://orcid.org/0000-0001-7587-5037Cho Sang-Cheol MDDivision of Cardiology, Heart Institute, Asan Medical Center, University of Ulsan, Seoul, Korea.Correspondence to Cheol Whan Lee, MD. Division of Cardiology, Heart Institute, Asan Medical Center, University of Ulsan, 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea. cheolwlee@amc.seoul.kr8 2018 15 5 2018 48 8 728 730 10 4 2018 16 4 2018 Copyright © 2018. The Korean Society of Cardiology2018The Korean Society of CardiologyThis is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.A Comparison of Transradial and Transfemoral Percutaneous Coronary Intervention in Chinese Women Based on a Propensity Score Analysis ==== Body Percutaneous coronary intervention (PCI) has been the mainstay of revascularization for patients with significant coronary artery disease. Traditionally, the femoral artery has been the preferred access site for PCI because of its larger size, easy access, and use of large-sized catheters. However, the femoral approach confers a greater risk of access site vascular complications, including hematomas, retroperitoneal hemorrhage, pseudoaneurysm, and arteriovenous fistulas. Femoral access site complications were initially reported in up to 10% of cases1)2) and remain an important clinical issue. The transradial approach was first introduced by Compeau1) in 1989 for coronary angiography. It continued to evolve in application, and is now commonly used for PCI because it allows early ambulation and earlier discharge, and has a lower risk of morbidity and mortality. With advances in devices and techniques, transradial PCI is increasingly being adopted in real-world clinical practice. However, as the size of the radial artery is relatively smaller in Asians than in Westerners, Asian patients have a higher risk of radial artery injury and local complications.3)4)5) Furthermore, the radial approach is technically more difficult in women than in men because of their smaller-caliber radial artery and higher risk of radial artery spasm. In this issue of the Korean Circulation Journal,6) the investigators compared the safety and efficacy of transradial and transfemoral PCI in Chinese women. In 899 propensity score-matched patients, transradial PCI was associated with reduced major post-PCI bleeding (odds ratio [OR], 0.64; 95% confidence interval [CI], 0.54–0.76; p<0.001) and access site complications (OR, 0.67; 95% CI, 0.61–0.74; p<0.001). The incidence of major adverse cardiac events was similar between the 2 groups. These findings show the advantage of transradial PCI over transfemoral PCI in Asian women, demonstrating that PCI can be safely performed through a transradial approach even in Asian women. A number of studies have demonstrated the superiority of transradial over transfemoral access for PCI with regard to both access site complications and clinical outcomes, leading to an exponential increase in the adoption of the transradial approach.7)8)9)10) In the RadIal Versus femorAL access for coronary intervention (RIVAL) trial, 3,507 patients with acute coronary syndrome who were undergoing coronary angiography with possible intervention were randomized to either the radial or femoral approach.8) There was no difference in primary outcome (composite of death, myocardial infarction, stroke, or non-coronary artery bypass graft-related major bleeding) at 30 days. However, there was a significant interaction for the primary outcome favoring the radial approach in the highest tertile volume radial centers (hazard ratio [HR], 0.49; 95% CI, 0.28–0.87; p=0.015) and in patients with ST-segment elevation myocardial infarction (HR, 0.60; 95% CI, 0.38–0.94; p=0.026). The incidence of local vascular complications was significantly lower in the radial group than in the femoral group. In the Radial Versus Femoral Randomized Investigation in ST-Elevation Acute Coronary Syndrome (RIFLE-STEACS) trial, 1,001 patients with ST-segment elevation myocardial infarction undergoing primary PCI were randomized to the radial or femoral approach.9) The primary outcome (composite of cardiac death, stroke, myocardial infarction, target lesion revascularization, and bleeding) at 30 days was significantly lower in the radial group than in the femoral group (13.6% vs. 21.0%, p=0.003). In addition, the radial (vs. femoral) approach was associated with significantly lower rates of cardiac mortality, bleeding, and shorter hospital stay. In the Minimizing Adverse Haemorrhagic Events by TRansradial Access Site and Systemic Implementation of angioX (MATRIX Access) trial, 8,404 patients with acute coronary syndrome who were undergoing coronary angiography and PCI were randomized to either the transradial or the transfemoral approach.10) The net adverse clinical events (composite of all-cause mortality, myocardial infarction, stroke, or Bleeding Academic Research Consortium [BARC] type 3 or 5 bleeding) were lower in the radial group than in the femoral group (relative risk [RR], 0.83; 95% CI, 0.73–0.96; p=0.0092). The difference was driven by BARC major bleeding unrelated to coronary artery bypass graft surgery (RR, 0.67; 95% CI, 0.49–0.92; p=0.013) and all-cause mortality (RR, 0.72; 95% CI, 0.53–0.99; p=0.045). These findings show that in patients with acute coronary syndrome undergoing invasive procedures, the radial (as compared with the femoral) approach reduces the net adverse clinical events through a reduction in major bleeding and all-cause mortality. Taken together, randomized controlled clinical trials confirmed that the radial approach reduces bleeding and vascular complications after PCI compared with the femoral approach, especially in patients with acute coronary syndrome. The radial approach should be considered the preferred method for PCI in this clinical setting. Finally, there is no doubt that transradial PCI has more significant clinical benefits than transfemoral PCI. However, this approach requires a longer learning curve for the operator and also limits the use of certain devices, such as temporary pacemakers, left ventricular assist devices, and larger devices for PCI. In addition, transradial PCI is difficult to perform in patients with abnormal radial artery anatomy, small radial artery, or tortuous subclavian artery. In these special situations, tranfemoral PCI might be more appropriate. In summary, both radial and femoral approaches seem to be safe and effective for PCI. However, the radial approach is associated with a lower risk of local vascular complications. Conflict of Interest: The authors have no financial conflicts of interest. Author Contributions: Conceptualization: Lee CW, Cho SC. Data curation: Lee CW. Validation: Lee CW, Cho SC. Visualization: Lee CW, Cho SC. Writing - original draft: Lee CW. Writing - review & editing: Cho SC. The contents of the report are the author's own views and do not necessarily reflect the views of the Korean Circulation Journal. ==== Refs 1 Campeau L Percutanous radial artery approach for coronary angiography Cathet Cardiovasc Diagn 1989 16 3 7 2912567 2 Kiemeneij F Laarman GJ Percutaneous radial artery approach for coronary stent implantation Cathet Cardiovasc Diagn 1993 30 173 178 8221875 3 Pandie S Mehta SR Cantor WJ Radial versus femoral access for coronary angiography/intervention in women with acute coronary syndromes: insights from the RIVAL Trial (Radial Vs femorAL access for coronary intervention) JACC Cardiovasc Interv 2015 8 505 512 25907080 4 Kanei Y Kwan T Nakra NC Transradial cardiac catheterization: a review of access site complications Catheter Cardiovasc Interv 2011 78 840 846 21567879 5 Jang HJ Kim JY Han JD Numbness after transradial cardiac catheterization: the results from a nerve conduction study of the superficial radial nerve Korean Circ J 2016 46 161 168 27014346 6 Xu Y Jin C Qiao S A comparison of transradial and transfemoral percutaneous coronary intervention in Chinese women based on a propensity score analysis Korean Circ J 2018 48 719 727 30073810 7 Feldman DN Swaminathan RV Kaltenbach LA Adoption of radial access and comparison of outcomes to femoral access in percutaneous coronary intervention: an updated report from the national cardiovascular data registry (2007–2012) Circulation 2013 127 2295 2306 23753843 8 Jolly SS Yusuf S Cairns J Radial versus femoral access for coronary angiography and intervention in patients with acute coronary syndromes (RIVAL): a randomised, parallel group, multicentre trial Lancet 2011 377 1409 1420 21470671 9 Romagnoli E Biondi-Zoccai G Sciahbasi A Radial versus femoral randomized investigation in ST-segment elevation acute coronary syndrome: the RIFLE-STEACS (Radial Versus Femoral Randomized Investigation in ST-Elevation Acute Coronary Syndrome) study J Am Coll Cardiol 2012 60 2481 2489 22858390 10 Valgimigli M Gagnor A Calabró P Frigoli E Leonardi S Zaro T Radial versus femoral access in patients with acute coronary syndromes undergoing invasive management: a randomised multicentre trial Lancet 2015 385 2465 2476 25791214