==== Front Beilstein J Org Chem Beilstein J Org Chem Beilstein Journal of Organic Chemistry 1860-5397 Beilstein-Institut Trakehner Str. 7-9, 60487 Frankfurt am Main, Germany 10.3762/bjoc.19.73 Full Research Paper Chemistry Organic Chemistry The unique reactivity of 5,6-unsubstituted 1,4-dihydropyridine in the Huisgen 1,4-diploar cycloaddition and formal [2 + 2] cycloaddition Chen Xiu-Yu 1 Zheng Hui 1 Han Ying hanying@yzu.edu.cn 1 Sun Jing 1 Yan Chao-Guo cgyan@yzu.edu.cn 1 Baxendale Ian Associate Editor 1 College of Chemistry & Chemical Engineering, Yangzhou University, Jiangsu, Yangzhou 225002, China https://ror.org/03tqb8s11 2023 29 6 2023 19 982990 10.3762/bjoc.19.733 5 2023 21 6 2023 Copyright © 2023, Chen et al. 2023 Chen et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article licensed under the terms of the Beilstein-Institut Open Access License Agreement (https://www.beilstein-journals.org/bjoc/terms/terms), which is identical to the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0). The reuse of material under this license requires that the author(s), source and license are credited. Third-party material in this article could be subject to other licenses (typically indicated in the credit line), and in this case, users are required to obtain permission from the license holder to reuse the material. The three-component reaction of isoquinolines, dialkyl acetylenedicarboxylates, and 5,6-unsubstituted 1,4-dihydropyridines in acetonitrile at room temperature afforded functionalized isoquinolino[1,2-f][1,6]naphthyridines in good yields and with high diastereoselectivity. More importantly, the formal [2 + 2] cycloaddition reaction of dialkyl acetylenedicarboxylates and 5,6-unsubstituted 1,4-dihydropyridines in refluxing acetonitrile gave unique 2-azabicyclo[4.2.0]octa-3,7-dienes as major products and 1,3a,4,6a-tetrahydrocyclopenta[b]pyrroles as minor products via further rearrangement. 1,4-dihydropyridine electron-withdrawing alkyne formal [2 + 2] cycloaddition Huisgen's 1,4-dipole isoquinoline isoquinolino[1,2-f][1,6]naphthyridine National Natural Science Foundation of China http://dx.doi.org/10.13039/501100001809 Chao-Guo Yan/21871227 This work was financially supported by the National Natural Science Foundation of China (Nos. 21572196, 21871227).All costs related to the publication of this open access article were entirely funded by the Beilstein-Institut. ==== Body pmcIntroduction Among various well-known cycloaddition reactions such as the 1,3-dipolar cycloaddition reaction, Diels–Alder reaction, and the Povarov reaction, the cycloaddition reaction of Huisgen 1,4-dipoles with activated alkenes received increasing attention [1–3]. The well-known Huisgen 1,4-dipoles have a special kind of zwitterionic intermediates and are usually prepared by a nucleophilic addition of pyridine, quinoline, isoquinoline and other aza-arenes to electron-deficient alkynes [4–8]. The reactive Huisgen 1,4-dipoles have been widely employed as one of the most valuable synthons to construct diverse carbocyclic and heterocyclic systems as well as many open-chain compounds [9–15]. In recent years, in situ generated Huisgen 1,4-dipoles were also widely employed to design highly efficient multicomponent and domino reactions [16–25]. Recently, much attention has been devoted to the development of new domino reactions containing reactive Huisgen 1,4-dipoles as key components for the assembly of many biologically important nitrogen-containing six-membered heterocyclic compounds [26–30]. The 5,6-unsubstituted 1,4-dihydropyridines can be easily prepared from the three-component reaction of an arylamine, cinnamaldehyde, and methyl acetoacetate [31–34]. The unsubstituted C=C double bond in 5,6-unsubstituted 1,4-dihydropyridines exhibits high reactivity and could act as activated alkene to take part in various cycloaddition reactions [35–40]. For example, Lavilla and co-workers developed a Sc(OTf)3-catalyzed three-component reaction of 5,6-unsubstituted 1,4-dihydropyridines, arylamines and ethyl glyoxylate for the preparation of various pyrido-fused tetrahydroquinolines (reaction 1 in Scheme 1) [41–42]. Menéndez and co-workers reported a Yb(OTf)3-mediated Povarov reaction of imines and N-alkyl-1,4-dihydropyridines for the synthesis of hexahydrobenzo[h][1,6]naphthyridines (reaction 2 in Scheme 1) [43]. Khan and co-workers employed a one-pot Povarov reaction of 3-aminocoumarins, aldehydes, and 5,6-unsubstituted 1,4-dihydropyridine derivatives for the construction of exo-hexahydrochromeno[3,4-h][1,6]naphthyridine-3-carboxylate derivatives (reaction 3 in Scheme 1) [44]. In these reactions, the 5,6-unsubstituted 1,4-dihydropyridines usually behaved as an activated electron-rich dienophile. Inspired by these elegant synthetic methodologies and in continuation of our aim to develop well-known Huisgen 1,4-dipoles for the construction of diverse nitrogen-containing heterocyclic compounds [45–64], herein, we wish to report the use of 5,6-unsubstituted 1,4-dihydropyridines as electron-deficient alkenes in the Huisgen 1,4-diploar cycloaddition and as electron-rich alkenes in formal [2 + 2] cycloadditions for the efficient synthesis of isoquinolino[1,2-f][1,6]naphthyridine and 2-azabicyclo[4.2.0]octa-3,7-diene derivatives. Scheme 1 Various cycloaddition reactions of 5,6-unsymmetric 1,4-dihydropyridines. Results and Discussion Initially, the reaction conditions were briefly examined by using isoquinoline (1), dimethyl acetylenedicarboxylate (DMAD, 2) and 5,6-unsubstituted 1,4-dihydropyridine 3 as standard reaction (Table 1). The three-component reaction was carried out in common solvents such as ethanol, methanol, dichloromethane, and chloroform at room temperature for two hours. The expected isoquinolino[1,2-f][1,6]naphthyridine derivative 4a was successfully obtained in 35%, 40% 70% and 65% yields, respectively (Table 1, entries 1–4). The reaction in acetonitrile afforded the product 4a in 75% yield (Table 1, entry 5). When the reaction time was extended to 12 h at room temperature, the yield of product 4a did not increase (Table 1, entry 6). When the reaction was carried out in acetonitrile at elevated temperatures, the yield of product 4a decreased to 68% and 55% (Table 1, entries 7 and 8). Therefore, the optimal reaction conditions for this three-component reaction were simply carrying out the reaction in acetonitrile at room temperature for two hours. Table 1 Optimizing the reaction conditions.a Entry Solvent Temp. [°C] Time [h] Yield [%]b 1 EtOH rt 2 35 2 MeOH rt 2 40 3 CH2Cl2 rt 2 70 4 CHCl3 rt 2 65 5 MeCN rt 2 75 6 MeCN rt 12 72 7 MeCN 50 2 68 8 MeCN 80 2 55 aReaction conditions: isoquinoline (0.5 mmol), DMAD (0.6 mmol), 5,6-unsubstituted 1,4-dihydropyridine (0.5 mmol), solvent (5.0 mL). bIsolated yields. Under the optimal reaction conditions, various substrates were employed in the reaction for developing the scope of the reaction and the results are summarized in Table 2. It can be seen that all reactions gave the desired isoquinolino[1,2-f][1,6]naphthyridine derivatives 4a–o in good to excellent yields. Isoquinoline itself and its 4-, 5-, and 6-bromo-substituted derivatives were successfully used in the reaction. Dimethyl or diethyl acetylenedicarboxylates gave the products in comparable yields in the reaction. The 5,6-unsubstituted 1,4-dihydropyridines with an N-benzyl group usually gave the products in good yields (Table 2, entries 1–12). It should be pointed out that 6-unsubstituted 1,4-dihydropyridines with an N-(3,4-(CH3O)2C6H3CH2CH2) group also afforded the desired product 4h in 88% yield (Table 2, entry 8). Even 5,6-unsubstituted 1,4-dihydropyridines with an N-n-Bu group also gave the products 4m and 4n in satisfactory yields. At last, 5,6-unsubstituted 1,4-dihydropyridines derived from the condensation of acetylacetone also afforded the expected product 4o in 65% yield. The chemical structures of the obtained isoquinoline[2,1-h][1,7]naphthyridines 4a–o were fully characterized by various spectroscopy methods and further confirmed by determination of the single crystal structure of compound 4k (Figure 1, CCDC 2059918). Though there are four chiral centers in the product structure of the isoquinolino[1,2-f][1,6]naphthyridine, the 1H NMR spectra of the products all showed that only one diastereomer was produced in the reaction, which showed that this reaction has a high diastereoselectivity. From Figure 1, it can be seen that the three protons and the phenyl group have cis-configuration in the hexahydro-1,6-naphthyridyl ring. Table 2 Synthesis of isoquinolino[1,2-f][1,6]naphthyridines 4a–o.a Entry Compd R1 R2 Ar R3 R4 Yield [%]b 1 4a H CH3 C6H5 OCH3 Bn 75 2 4b H CH3 C6H5 OEt Bn 65 3 4c H CH3 p-FC6H4 OCH3 Bn 58 4 4d H CH3 p-CH3OC6H4 OCH3 Bn 88 5 4e H C2H5 C6H5 OCH3 Bn 80 6 4f H C2H5 C6H5 OC2H5 Bn 82 7 4g H CH3 C6H5 OCH3 p-CH3OC6H4CH2 84 8 4h H CH3 C6H5 OCH3 3,4-(CH3O)2C6H3(CH2)2 88 9 4i 4-Br CH3 C6H5 OCH3 Bn 78 10 4j 5-Br CH3 C6H5 OCH3 Bn 67 11 4k 6-Br CH3 C6H5 OCH3 Bn 65 12 4l 4-Br CH3 C6H5 OC2H5 Bn 74 13 4m H CH3 C6H5 OCH3 n-Bu 77 14 4n 5-Br CH3 C6H5 OCH3 n-Bu 78 15 4o H CH3 C6H5 CH3 Bn 65 aReaction conditions: isoquinoline (0.5 mmol), dialkyl acetylenedicarboxylate (0.6 mmol), 5,6-unsubstituted 1,4-dihydropyridine (0.5 mmol), CH3CN (5.0 mL), rt, 2 h. bIsolated yields. Figure 1 Single crystal structure of the compound 4k. During the investigation of the above three-component reaction, we found that the three-component reaction of isoquinoline, dimethyl acetylenedicarboxylate and 5,6-unsubstituted 1,4-dihydropyridines with N–Ar groups did not give the above isoquinolino[1,2-f][1,6]naphthyridines, but the unique 2-azabicyclo[4.2.0]octa-3,7-diene-7,8-dicarboxylates were isolated in moderate yields. These products were obviously produced from the formal [2 + 2] cycloaddition between dimethyl acetylenedicarboxylate and the 5,6-unsubstituted 1,4-dihydropyridine. Therefore, the reactions of dimethyl acetylenedicarboxylate and 5,6-unsubstituted 1,4-dihydropyridines were carefully explored. After adjusting the reaction conditions, we were pleased to find that 2-azabicyclo[4.2.0]octa-3,7-dienes 5a–o could be successfully obtained in moderate to good yields by carrying out the reaction of dimethyl acetylenedicarboxylate and 5,6-unsubstituted 1,4-dihydropyridines in refluxing acetonitrile for three hours (Table 3). As can be seen, unsymmetric 1,4-dihydropyridines with N–Bn and N-4-(CH3OC6H4CH2) groups can be successfully employed in the reaction (Table 3, entries 1–10). Additionally, 5,6-unsubstituted 1,4-dihydropyridines with various N–Ar groups also gave the expected products 5k–o in good yields. Sometimes, as unexpected byproducts, 1,3a,4,6a-tetrahydrocyclopenta[b]pyrrole derivatives 6e, 6f, 6i, 6k, 6l, and 6m were isolated in 23–39% yield from the reaction mixture. In other cases, the corresponding 1,3a,4,6a-tetrahydrocyclopenta[b]pyrrole derivatives could not be isolated due to too low yields. By analyzing the chemical structures of the 1,3a,4,6a-tetrahydrocyclopenta[b]pyrrole derivatives 6, it was found that the 1,4-dihydropyridinyl ring of the substrate was converted to a fused pyrrole ring, which might be a result from a rearrangement process of the formed 2-azabicyclo[4.2.0]octa-3,7-diene-7,8-dicarboxylates 5a–o at elevated temperature. The chemical structures of both bicyclic compounds 5a–o and 6a–o were fully characterized by various spectroscopy methods. The single crystal structures of compounds 5a (Figure 2) and 6f (Figure 3) were successfully determined by X-ray diffraction analysis. From Figure 2 (compound 5a), it can be seen that the cyclobutenyl ring and the 1,4-dihydropyridyl ring exist on the fused position. The two protons at the bridged position and the phenyl group are cis-configured. From Figure 3 (compound 6f), it can be seen that the fused pyrrole ring and the cyclopentyl ring are butterfly shaped. The unusual feature is that the C=C double bond is not located between the two carbon atoms substituted with the methoxycarbonyl groups, but between the methylene carbon atom and one carbon atom connected with an electron-withdrawing methoxycarbonyl group. The aryl group and the neighbouring methoxycarbonyl group are cis-configured. Table 3 Synthesis of the bicyclic compounds 5a–o and 6a–o.a Entry R1 Ar R2 Compd Yield (%)b Compd Yield (%)b 1 CH3 C6H5 Bn 5a 89% 6a – 2 CH2CH3 C6H5 Bn 5b 70% 6b – 3 CH3 o-CH3OC6H4 Bn 5c 80% 6c – 4 CH2CH3 o-CH3OC6H4 Bn 5d 65% 6d – 5 CH2CH3 p-NO2C6H4 Bn 5e 36% 6e 35% 6 CH3 C6H5 p-CH3OC6H4CH2 5f 40% 6f 23% 7 CH3 o-CH3OC6H4 p-CH3OC6H4CH2 5g 57% 6g – 8 CH2CH3 o-CH3OC6H4 p-CH3OC6H4CH2 5h 62% 6h – 9 CH2CH3 p-NO2C6H4 p-CH3OC6H4CH2 5i 41% 6i 39% 10 CH3 p-NO2C6H4 p-CH3OC6H4CH2 5j 64% 6j – 11 CH3 C6H5 p-CH3OC6H4 5k 35% 6k 36% 12 CH2CH3 C6H5 p-CH3C6H4 5l 31% 6l 33% 13 CH3 C6H5 p-BrC6H4 5m 33% 6m 35% 14 CH3 C6H5 m-ClC6H4 5n 55% 6n – 15 CH3 o-CH3OC6H4 o-CH3C6H4 5o 64% 6o – aReaction conditions: dialkyl acetylenedicarboxylate (0.9 mmol), 5,6-unsubstituted 1,4-dihydropyridine (0.3 mmol), CH3CN (5.0 mL), reflux, 3 h. bIsolated yields. Figure 2 Single crystal structure of compound 5a. Figure 3 Single crystal structure of compound 6f. For explaining the formation of the various cyclic compounds, a plausible reaction mechanism was proposed on the base of the previously reported works [41–44] and the present experiments (Scheme 2). Initially, the nucleophilic addition of isoquinoline to dimethyl acetylenedicarboxylate gives the well-known Huisgen 1,4-dipole A. Secondly, Michael addition of the 1,4-dipole A to 5,6-unsubstituted 1,4-dihydropyridine gives the adduct intermediate B. At last, the intramolecular coupling of the negative and the positive charges in intermediate B directly affords isoquinolino[1,2-f][1,6]naphthyridines 4. Because all reactions in this process are retro-equilibrium reactions, the most thermodynamically stable diastereomer is preferentially produced in the reaction. In the absence of isoquinoline, the 5,6-unsubstituted 1,4-dihydropyridine acts as an active enamine, which adds to dimethyl acetylenedicarboxylate to give the adduct C. Then, the direct coupling of the positive charge and the negative charge affords the 2-azabicyclo[4.2.0]octa-3,7-diene 5. On the other hand, a carbenium ion D can be formed by migration of a hydrogen atom in intermediate C, which in turn converts into a fused bicyclic intermediate E by a charge coupling process. At elevated temperature, the ring-opening of the unstable cyclobutenyl ring gives a 1,2-dihydroazocine intermediate F, which is transformed into a 1,4-dihydroazocine intermediate G by a 1,5-H shift process. At last, the tetrahydrocyclopenta[b]pyrrole 6 is formed by an intramolecular Michael addition process. Scheme 2 Plausible reaction mechanism for the various products 4, 5, and 6. Conclusion In summary, we have investigated the three-component reaction of isoquinoline, dialkyl acetylenedicarboxylate and 5,6-unsubstituted 1,4-dihydropyridines. This reaction successfully provided an efficient protocol for the synthesis of functionalized isoquinolino[1,2-f][1,6]naphthyridines in good yields and with high diastereoselectivity. We also found that the unique 2-azabicyclo[4.2.0]octa-3,7-diene and 1,3a,4,6a-tetrahydrocyclopenta[b]pyrrole derivatives can be conveniently produced by the cycloaddition reaction of dialkyl acetylenedicarboxylates and 5,6-unsubstituted 1,4-dihydropyridines. The advantages of the reaction include the use of readily available starting materials, simple reaction conditions, without using any catalyst, high molecular diversity and atomic economy. Therefore, this reaction not only successfully developed unprecedented synthetic reactivity of the electron-deficient alkynes, but also provides efficient synthetic methodologies for complex nitrogen-containing heterocycles. The potential application of this reaction in organic synthesis and medicinal chemistry might be significant. Experimental General procedure for the three-component reaction of isoquinoline, dialkyl acetylenedicarboxylate and 5,6-unsubstituted 1,4-dihydropyridine A mixture of isoquinoline (0.5 mmol), dialkyl acetylenedicarboxylate (0.6 mmol), 5,6-unsubstituted 1,4-dihydropyridine (0.5 mmol) in acetonitrile (5.0 mL) was stirred at room temperature for two hours. After removing the solvent by rotatory evaporation at reduced pressure, the residue was subjected to column chromatography with petroleum ether and ethyl acetate (v/v = 5:1) as eluent to give the pure product for analysis. Trimethyl 4-benzyl-3-methyl-1-phenyl-4,4a,13b,13c-tetrahydro-1H-isoquinolino[1,2-f][1,6]naphthyridine-2,5,6-tricarboxylate (4a): orange solid, 75%; mp 174–175 °C; 1H NMR (400 MHz, CDCl3) δ 7.48–7.42 (m, 4H, ArH), 7.39–7.35 (m, 1H, ArH), 6.80 (t, J = 7.6 Hz, 1H, ArH), 6.75–6.71 (m, 4H, ArH), 6.63 (d, J = 6.4 Hz, 2H, ArH), 6.39 (t, J = 7.6 Hz, 1H, ArH), 6.22 (d, J = 8.0 Hz, 1H, ArH), 5.91 (d, J = 8.0 Hz, 1H, CH), 5.43 (d, J = 8.0 Hz, 1H, CH), 5.25 (s, 1H, CH), 5.04 (d, J = 15.6 Hz, 1H, CH2), 4.60 (d, J = 6.0 Hz, 1H, CH), 4.45 (d, J = 15.6 Hz, 1H, CH2), 4.17 (d, J = 8.8 Hz, 1H, CH), 3.93 (s, 3H, OCH3), 3.77 (s, 3H, OCH3), 3.28 (s, 3H, OCH3), 2.60 (t, J = 7.6 Hz, 1H, CH), 2.44 (s, 3H, CH3) ppm; 13C NMR (100 MHz, CDCl3) δ 168.7, 166.2, 164.9, 150.2, 146.1, 145.7, 138.7, 129.3, 128.8, 128.1, 128.0, 127.8, 127.5, 127.3, 127.0, 126.3, 126.1, 125.1, 124.7, 124.6, 106.3, 104.6, 102.8, 61.3, 57.6, 56.0, 53.0, 51.6, 50.0, 44.8, 39.5, 17.9 ppm. IR (KBr) ν: 3732, 3023, 2952, 2843, 1967, 1737, 1678, 1556, 1372, 1147, 1097, 1010, 957, 866, 759 cm−1; HRESIMS (m/z): [M + Na]+ calcd for C36H34NaN2O6, 613.2315; found, 613.2309. General procedure for the reaction of dialkyl acetylenedicarboxylate and 5,6-unsubstituted 1,4-dihydropyridine A mixture of dialkyl acetylenedicarboxylate (0.9 mmol), 5,6-unsubstituted 1,4-dihydropyridine (0.3 mmol) in acetonitrile (5.0 mL) was heated a reflux for three hours. After removing the solvent by rotatory evaporation at reduced pressure, the residue was subjected to column chromatography with petroleum ether and ethyl acetate (v/v = 6:1) as eluent to give the pure product for analysis. 7,8-Diethyl 4-methyl 2-benzyl-3-methyl-5-(4-nitrophenyl)-2-azabicyclo[4.2.0]octa-3,7-diene-4,7,8-tricarboxylate (5e): yellow solid, 36%; mp 161–163 °C; 1H NMR (400 MHz, CDCl3) δ 8.07–8.05 (m, 2H, ArH), 7.37–7.34 (m, 2H, ArH), 7.33–7.29 (m, 3H, ArH), 7.13–7.10 (m, 2H, ArH) 4.86 (d, J = 15.2 Hz, 1H, CH2), 4.59 (s, 1H, CH), 4.48 (d, J = 15.2 Hz, 1H, CH2), 4.37–4.34 (m, 1H, CH), 4.34–4.31 (m, 2H, CH2), 4.31–4.26 (m, 2H, CH2), 3.71 (d, J = 4.4 Hz, 1H, CH), 3.63 (s, 3H, OCH3), 2.51 (s, 3H, CH3), 1.40–1.37 (m, 3H, CH3), 1.37–1.33 (m, 3H, CH3) ppm; 13C NMR (100 MHz, CDCl3) δ 169.3, 160.9, 160.7, 156.2, 152.0, 146.4, 144.5, 137.2, 136.1, 128.7, 128.5, 128.1, 127.9, 123.4, 101.1, 61.5, 61.4, 56.6, 53.8, 51.8, 51.0, 38.9, 17.3, 14.1, 14.1 ppm; IR (KBr) ν: 3746, 2983, 2945, 1729, 1651, 1557, 1434, 1347, 1251, 1129, 1088, 841, 732, 709 cm−1; HRESIMS (m/z): [M + H]+) calcd for C29H31N2O8, 535.2075; found, 535.2076. 4,5-Diethyl 3-methyl 1-benzyl-2-methyl-3a-(4-nitrophenyl)-1,3a,4,6a-tetrahydrocyclopenta[b]pyrrole-3,4,5-tricarboxylate (6e): yellow solid, 35%; mp 153–155 °C; 1H NMR (400 MHz, CDCl3) δ 7.98 (d, J = 8.8 Hz, ArH), 7.45–7.37 (m, 5H, ArH), 7.30–7.27 (m, 2H, ArH), 6.70 (s, 1H, CH2), 5.07–5.05 (m, 1H, CH), 5.00–4.98 (m, 1H, CH), 4.76 (d, J = 15.2 Hz, 1H, CH2), 4.37 (d, J = 15.6 Hz, 1H, CH2), 4.29–4.21 (m, 1H, CH2), 4.21–4.14 (m, 1H, CH2), 3.91–3.82 (m, 1H, CH2), 3.82–3.72 (m, 1H, CH2), 3.69 (s, 3H, OCH3), 2.34 (s, 3H, CH3), 1.29 (t, J = 7.2 Hz, CH3), 0.99 (t, J = 7.2 Hz, CH3) ppm; 13C NMR (100 MHz, CDCl3) δ 172.2, 166.1, 163.5, 158.0, 149.9, 146.3, 137.8, 137.4, 135. 9, 129.2, 128.5, 128.0, 127.2, 123.0, 101.9, 75.5, 62.9, 61.1, 61.0, 58.3, 50.3, 49.2, 14.1, 13.8, 13.4 ppm; IR (KBr) ν: 3069, 2981, 1736, 1660, 1552, 1514, 1344, 1222, 1121, 1040, 914, 854, 769, 704 cm−1; HRESIMS (m/z): [M + Na]+ calcd for C29H30NaN2O8, 557.1894; found, 557.1891. Supporting Information The crystallographic data of compounds 4k (CCDC 2260340), 5a (CCDC 2260341), and 5f (CCDC 2260342) have been deposited at the Cambridge Crystallographic Data Center (https://www.ccdc.cam.ac.uk). 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