==== Front Cureus Cureus 2168-8184 Cureus 2168-8184 Cureus Palo Alto (CA) 10.7759/cureus.39893 Emergency Medicine Psychiatry Forensic Medicine Psychosocial Factors Behind Deliberate Self-Poisoning in a Tertiary Care Hospital of Bangladesh: A Cross-Sectional Study Muacevic Alexander Adler John R Bhattacharjee Binayak 1 Roy Soumitra 2 Alam M. M. Jahangir 2 Royle R. K. S. 3 Paul Shrebash 4 Islam Md Sohidul 5 Bari Md. Shafiqul 6 Chowdhury Fazle Rabbi 57 1 Internal Medicine, Sylhet Shaheed Shamsuddin Ahmed Hospital, Sylhet, BGD 2 Internal Medicine, Sylhet MAG Osmani Medical College Hospital, Sylhet, BGD 3 Psychiatry, Sylhet MAG Osmani Medical College Hospital, Sylhet, BGD 4 Infectious Disease and Tropical Medicine, Infectious Disease Hospital, Dhaka, BGD 5 Internal Medicine, Bangabandhu Sheikh Mujib Medical University, Dhaka, BGD 6 Internal Medicine, Dhaka Medical College Hospital, Dhaka, BGD 7 Toxicology, Toxicology Society of Bangladesh, Dhaka, BGD Fazle Rabbi Chowdhury rabbimedicine@bsmmu.edu.bd 2 6 2023 6 2023 15 6 e398931 6 2023 Copyright © 2023, Bhattacharjee et al. 2023 Bhattacharjee et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. This article is available from https://www.cureus.com/articles/149387-psychosocial-factors-behind-deliberate-self-poisoning-in-a-tertiary-care-hospital-of-bangladesh-a-cross-sectional-study Introduction: Deliberate self-poisoning (DSP) is an important cause of hospital admissions and subsequent mortality. We conducted a cross-sectional observational study in a tertiary-level teaching hospital situated in the northeastern part of Bangladesh to analyze the psychosocial factors responsible for DSP. Methods: This cross-sectional observational study was carried out among patients with DSP admitted to the medicine ward from January to December 2017, irrespective of gender, except for cases involving poisoning due to spoiled food, food contaminated by infectious organisms, poisoning by venomous animals, and street poisoning (commuter or travel-related poisoning). Consultant psychiatrist in accordance with the Diagnostic & Statistical Manual of Mental Disorder - IV (DSM-IV) confirmed psychiatric disorders. Data were analyzed by SPSS (Statistical Package for social sciences) version 16.0 (IBM Corp., Armonk, NY). Results: Total 100 patients were enrolled. Among them, 43% were male and 57% were female. The majority (85%) of the patients were young, aged below 30 years. The mean age of male patients was 26.2 years and that of females was 21.69 years. Most of the DSP patients were from the lower economic class (59%). The population sample was remarkable for students (Prevalence 37%). The highest percentage of patients (33%) had their educational status at the secondary level. The common reasons for DSP were a family problem in 31% patients, quarrel with boy/girlfriend in 20%, quarrel with a spouse in 13%, quarrel with parents or other family member in 7%, failure in examination in 6%, poverty in 3%, and unemployment in 3%. Prescription medication was the most common poison material (38%), followed by insecticides (36%), household cleaners (17%), and rodenticides (8%). Seven (7%) patients reported previous deliberate self-harm events and co-morbid psychiatric disorder was present in 30% patients among them major depressive disorder was found in 60%, and schizophrenia in 23.3% cases. Conclusion: DSP remains a problem mainly for the young with gender ratio-favoring females. The majority of DSPs were educated up to secondary level, unmarried, residents of rural areas, student, and belonged to the lower class. Familial disharmony and quarrel with spouse or friends were the common reason behind DSP. Prescription medication and insecticides were commonly used for DSP. Psychiatric disorders, primarily depressive disorder, and schizophrenia were common in cases of DSP. deliberate self-poisoning poisoning psycho-social depressive disorder suicide ==== Body pmcIntroduction Deliberate self-poisoning (DSP) is an important health problem throughout the world especially in developing countries [1]. It is a major cause of more than 500,000 deaths per year in the Asia Pacific region [2]. It is an important health issue in the context of adolescents and younger populations. Young, married females constitute the majority of persons attempting deliberate self-harm [3]. The commonest compound used for DSP varies at different places. In developing countries, benzodiazepines and organophosphorus (OP) pesticides are used commonly in urban and rural areas, respectively [1,3]. Persons attempting DSP may have various intentions, of which, using it as a means of communication, threatening and suicidal are the most important [4]. The majority of the persons attempting DSP do not want to commit suicide [5]. They do so as they are depressed, have anger, jealousy, or desire for attention [4]. OP compounds are generally used for DSP with suicidal intentions because of their well-known fatality index [1]. Mental disorders and previous attempts at DSP are associated with poor outcomes like death. In Bangladesh, pesticide poisoning accounted for 39.1% of total poisoning cases and OP compound constitutes 89.8% while pesticide poisoning causes approximately 0.7 deaths per 100,000 population [6]. The poisoning agents in Bangladesh are different because of the social structure, economic status, educational level, awareness of the people, and availability of drugs [7]. The important reasons for suicidal poisoning in Bangladesh are lack of education, frustration, familial disharmony, failure of love affairs, failure in the examination, and the availability of the poison [7,8]. The socio-economic condition of people in the developing world has led to a higher suicidal rate as compared to the Western world. The pattern of poisoning changes over time and varies from country to country and even within regions of countries [9,10]. This study tried to identify the possible psychosocial factors responsible for DSP among patients admitted to a tertiary hospital in Bangladesh. Materials and methods This cross-sectional observational study was carried out in the Department of Medicine, Sylhet MAG Osmani Medical College Hospital, Sylhet, Bangladesh from January to December 2017. Sylhet M.A.G. Osmani Medical College Hospital is the largest medical college hospital in the northeastern part of the country. It has more than 1,000-bed capacity with a bed occupancy rate of 162%. The inclusion criteria of our study were all patients with DSP of 18 years and above irrespective of gender and all who gave consent; Exclusion criteria were accidental poisoning (poisoning due to spoiled food, food contaminated by infectious organisms), poisoning by venomous animals, and street poisoning. Socio-economic status has been categorized as “Higher class” having a monthly family income of more than Tk. 20,000.00, “Middle class” having a monthly family income of Tk. 10,000.00 to 20,000.00 and “Lower class” having monthly family income of less than Tk. 10,000.00. A psychiatric assessment was done after the recovery. A psychiatric interview was to elicit the symptoms, history, and background information from both the patient and informant, and a mental state examination was done by the psychiatric consultant. The patient and informant were asked to describe the course of the psychiatric symptoms if any, family history, personal history, previous medical and psychiatric history along with previous personality history. Psychological assessment of DSP patients was categorized using the Diagnostic & Statistical Manual of Mental Disorder- IV (DSM-IV)-TR. The sample size was calculated using Cochran's formula considering a 5% level of significance, a 5% precision level (marginal error), and estimating the prevalence of poisoning as 7.1% [6]. Purposive random sampling was employed as a sampling technique in this study. Every day at least three new patients with DSP were randomly approached and consent was recorded. Data were processed manually and analyzed with the help of SPSS (Statistical Package for social sciences) version 16.0 (IBM Corp., Armonk, NY). Quantitative data were expressed as mean and standard deviation, and comparisons were done by the “Z” test. Discrete and categorical variables were expressed as frequency and percentage; the comparison was carried out by Chi-square (χ2) Test. A probability value (p) of less than 0.05 was considered to indicate statistical significance. Results A total of 100 patients were included in this study. Out of them, 57% were female. The age of the patients ranged from 18 to 65 years. The majority (85%) of the patients were young, aged below 30 years, 10% of cases between 31 and 40 years and rest were above 41 years. Among the total patients, 67% were unmarried, 86% patients were Muslim, 73% patients were from a nuclear family, 59% were patients from rural, 30% were patients from urban and 11% patients were from sub-urban society. Most of the DSP patients (59%) were from the lower socio-economic class, followed by the middle class (40%). About one-third of the DSP patients were students (37%). Out of the remaining two-thirds, 16% were homemakers, 12% were unemployed, 10% were day laborers and 09% were farmers. Most of the DSP patients in this study were educated up to various levels and 12% were illiterate (Table 1). Table 1 Socio-demographic characteristics of DSP patients (n=100) Socio-demographic Variables Percentage Age distribution with Mean age & Range(Years)   All , 23.6 & (14-65) 100 (n=100) Male , 26.2 & (16-65) 43 (n=43) Female , 21.7 & (14-34) 57 (n=57)     Age group (years)   <20 46 21-30 39 31-40 10 41-50 03 51-60 01 >60 01 Gender   Male 43 Female 57 Education   Illiterate 12 Primary 26 Secondary 33 Higher secondary 19 Graduate 09 Post graduate 01 Marital status   Married 33 Unmarried 67 Occupation   Students 37 Housewife 16 Unemployed 12 Others 12 Day laborer 10 Farmer 09 Service 02 Business 02 Social background   Rural 59 Urban 30 Semi urban 11 Religion   Islam 86 Hinduism 14 Family type   Nuclear 73 Joint family 27 Interpersonal relationship problem (quarrel with a boy/girlfriend or with spouse) was the most common (33%) reason followed by familial disharmony (31%). Other reasons behind DSP were quarrels with parents or other family members (7%), failure in examination (6%), poverty (3%), unemployment (3%) and others (17%) (Table 2). Age and occupation had significant relation with the cause of DSP (p<0.05). In most of the patients below 30 years of age, the cause for DSP is family problems (61.2%). Familial disharmony and quarrel with boy/girlfriend (27% in each case) was the most common reason for DSP amongst students. DSP among homemakers is more commonly due to quarrels with spouses (43.8%). Prescription medication ingestion was the most common method (38%), followed by ingestion of insecticides (36%), household cleaners (17%), rodenticides (8%) and others (1%) (Table 2). Table 2 Clinical characteristics of DSP patients (n=100) Clinical Condition Percentage Reason behind DSP   Familial disharmony 31 Quarrel with boy/girlfriend 20 Quarrel with spouse 13 Quarrel with parents or family members 07 Failure in examination 06 Poverty 03 Unemployment 03 Others 17 Types of poison materials used   Prescription medication ingestion 38 Pesticides, insecticides 36 Household cleaner 17 Rodenticide 08 Others 01 Co-morbid specific psychiatric disorders   Major depressive disorder 18 Schizophrenia 07 Bipolar affective disorder 02 Substance use disorder 02 Post-traumatic stress disorder 01 No psychiatric disorder 70 Education, occupation, economic and social background has more influence on the type of poison material used for DSP. Illiterate and patients educated up to a primary and secondary level more commonly used insecticides (illiterate - 91.7%, primary - 42.3%, secondary - 33.3%) whereas patients with a higher level of education used drugs more commonly (higher secondary - 73.7%, graduate - 66.7%). In terms of occupation, there is some variability in the types of poisons used by different occupations. Most of the students and homemakers used drugs (students - 54.1%, homemakers - 62.5%) and most farmers, day laborers and unemployed people used insecticides for DSP (farmers - 66.7%, day laborers - 80%, and unemployed - 66.7%) (Table 3). Table 3 Relation of occupation and type of poisons used     Type of poisons Total   p- value Insecticides Prescribed drug ingestion Household cleaner Rodenticide Others Occupation Service 0 0 2 0 0 2             .000 Business 0 2 0 0 0 2 Farmer 6 2 0 1 0 9 Student 4 20 10 3 0 37 Homemaker 5 10 0 1 0 16 Unemployed 8 1 3 0 0 12 Day laborer 8 1 1 0 0 10 Others 5 2 1 3 1 12 Total 36 38 17 8 1 100 Patients belonging to lower socioeconomic classes more commonly used insecticides (52.5%) and middle-class patients used drugs (70%) for DSP. Rural people more commonly used insecticides (54.2%) and people residing in the urban and suburban areas used drugs more commonly (urban - 70%, suburban - 63.6%). The source of poison materials was buying from the local shop in 37% of cases, household materials in 37%, and prescribed medications in 16% of patients. Seven (7%) patients reported previous attempts of deliberate self-harm. A co-morbid psychiatric disorder was present in 30% of cases. Among them, major depressive disorder (MDD) was the most common psychiatric disorder (60%), followed by schizophrenia (23.3%), bipolar affective disorder (6.7%), substance use disorder (6.7%) and post-traumatic stress disorder (3.3%) cases. The source of poison and different type of psychiatric disorders has a significant relationship with each other (p-value=0.04). In 72.2% of cases of patients with MDD bought poison from shops whereas in 85.7% cases of patients with schizophrenia got poisoned by household materials (Table 4). Table 4 Relation of source of poison and type of psychiatric disorder Chi-square and fishers exact test was used to explore the level of significance     Type of psychiatric disorder Total     p- value No psychiatric disorder MDD Schizophrenia Bipolar affective disorder PTSD substance abuse disorder with impulsivity Source of poison Household materials 26 3 6 1 1 0 37       0.04 Shop 32 13 0 0 0 2 47 Prescribed drugs 12 2 1 1 0 0 16 Total 70 18 7 2 1 2 100 Discussion The male-to-female ratio in this study was 1:1.35. DSP is an indirect indicator of psychological distress, and the finding on male/female differences suggested that females probably faced more psychological distress than males. The fact also indicates that females in Bangladesh face different difficulties such as domestic violence and abuse. In previous studies done in Bangladesh, males were found to be involved more than females. Those studies included street or commuter poisoning in the data which probably drew the difference. Males are more mobile and thus can easily become victims of street poisoning [11-16]. In this study, the mean age of the female patients was significantly lower than that of male patients (p<0.01). The result is concordance with the study of Srivastava et al. [17] and Akbaba et al. [18]. Amin et al. showed that the mean age (± SD, years) of the poisoning patients was 26±13 years with a wide variation in the range probably due to the inclusion of accidental poisoning and snakebite in that study [11]. In all of these studies, the mean age for DSP patients was found to be under 30 years. This result is similar to a baseline survey on poisoning cases done by Faiz, which showed a majority of DSP patients belonged to 13-20 years [12]. Below 30 years age group was also found to be more vulnerable to poisoning in a study done by Chowdhury et al. [13]. However, another study done by Howlader et al. [14] showed that the majority of poisoning cases belonged to 36-45 years (40%), which was due to involvement of street poisoning (commuter/travel related) and again, this age group is more active and mobile than others and more vulnerable to street poisoning. Teenagers are more vulnerable to DSP because they are more prone to be emotionally impulsive. They begin to develop their own existence and want to come out of the guardianship of parents or seniors and there may be a virtual conflict between two generations. In this age group, attraction to the opposite gender is at its extreme. So, there is every possibility of having a boy/girlfriend, and quarrels between them or breaking up makes them vulnerable to DSP [5,11]. Most of the patients belong to a low socio-economic group which is similar to other studies done in Bangladesh [7,8,11,13]. People from lower socio-economic groups are exposed to social and economic deprivation leading to a stressful life. Furthermore, people from the upper socio-economic class are less willing to get admitted to government hospitals. This is probably the reason behind having less patients of the upper socio-economic class in this study. Patients belonging to lower socioeconomic class (52.5%) more commonly used insecticides and middle-class patients (70%) used the drugs as an offending agent. Agriculture is the main means of living for lower economic class people and they have easy access to pesticides. This study showed that 73% of the DSP patients were from the nuclear family and 27% of patients were from the joint family. This result is similar to the study of Srivastava et al. and Narang et al. [17,19]. People living in the nuclear family become self-centered. Usually, they have less chance to get knowledge of customs and religion from elders, i.e., grandfather or grandmother or other family members than parents. This may be the cause of the difference found in this study among joint and nuclear families. Emotional support in a joint family can also be a protective factor against DSP. In this study, one-third (37%) cases were students, followed by housewives (16%), unemployed (12%), and others, e.g., day laborers, farmers, business, and service. Other studies conducted in different countries also found the same [16,20,21]. In our study, familial disharmony and interpersonal relationship problems (quarrel with boy/girlfriend) were the most common reasons behind DSP in students. Quarrel with spouse was the major reason behind DSP amongst homemakers. The majority of homemakers involved in DSP faced domestic violence and abuse. The most common method of DSP amongst students and homemakers was the use of drugs and most of the farmers, day laborers, and unemployed person used insecticides. This may be due to the availability of the substance to a particular group of people. A low educational status was found in one-third of the cases in this study. A similar result was reported by some other studies [14,20,22]. However, this result differs from the study done by Srivastava et al. [17] in India which found that more than half of the patients were illiterate. DSP patients educated up to primary and secondary levels more commonly used pesticides, whereas patients with higher levels of education commonly used drugs. This could be explained by the lack of knowledge of less educated person regarding the lethality of pesticides or there may be a strong intention for suicide. In this study, most of the DSP patients (59%) came from rural areas, compared to urban (30%) and sub-urban (11%). These findings were in accordance with the findings of Amin et al. in Dhaka which showed that 60% of poisoning patients live in rural areas [11]. Andrus et al. found a difference in the USA where 19.8% of suicide attemptees lived in urban, 40.3% in rural and 39.8% in suburban areas [23]. However, some other studies showed that poisoning patients were mostly city or urban dwellers [15,20]. Rural people more commonly used insecticides (54.2%) and people residing in urban and suburban areas used drugs more commonly for DSP (urban - 70%, suburban - 63.6%). In rural areas, agents like organophosphate, carbamate, and others are easily available and people living in rural areas are more familiar with these substances. Moreover, they are less aware of the deleterious effects of poisoning. People residing in urban or suburban areas can easily get drugs either from home or buy from a pharmacy. In terms of religion, the Muslim population was most prevalent (86%) among DSPs as Bangladesh is a Muslim-majority country (91.04%) [24]. Although suicide is forbidden in every religion including Islam, however, those who commit DSP are not always influenced by religion. That is why one of the objectives of our study was to explore background psychiatric conditions that dragged them to DSP, and we found that 30% have a psychiatric illness. The common reasons behind DSP were found to be family disharmony, interpersonal relationship conflict, failure in examination, poverty, and unemployment. The finding is similar to other studies done in Indonesia and Ethiopia [25,26]. In terms of poisoning agents, the findings are similar to previous baseline studies done in Bangladesh [11,12], where prescription medication mainly sedatives were found to be the most common agent, followed by pesticides, household corrosives, and others. The findings were also similar in Japan (55.5% prescription medication) and Iran (60.8% prescription medication) [15,27]. However, Chowdhury et al. [13] reported a different scenario from the southern part of Bangladesh. The most commonly found toxic agents were organo-phosphate compound (27.6%) followed by unknown substance (16%), copper-sulfate (14%), and sedatives (13.4%) [13]. The reason for such a high ratio of prescription medication as a method of DSP is probably due to the extensive prescribing of these medications and their easy availability at home. Moreover, most medication can be bought without a prescription in Bangladesh. Seven (7%) of the participants had a previous history of DSP and five (5%) of the respondents had a history of a previous established psychiatric disorder. In Romania, Sorodoc et al. found that a total of 77.8% of patients were the first suicide attempter, 11.7% of patients had a history of two suicide attempts and 10.5% had records of more than two attempts [28]. Yamada et al. found that attempted suicide was the first time in 56.4%, second time in 22.5%, and third times or above in 21.1% of the cases [27]. Sorodoc et al. reported a history of psychiatric illness in 13.9% of the cases [28]. This study identified psychiatric disorders in 30% of DSP patients. A systematic review and meta-analysis by Knipe et al. also found a low prevalence of psychiatric disorders in suicidal tendency in low- and middle-income countries (an average of 45% in non-fatal suicidal tendency and 55% in those who died by suicide) compared to high-income countries (80%-90%) [29]. The common conditions we found in our study were MDD, schizophrenia, bipolar affective disorder, substance use disorder, and post-traumatic stress disorder. The findings were also supported by other studies [19,25,27] reported from different parts of the world. Community engagement and intervention (CEI) activities seriously lack in these psychiatric disorder issues. More CEI activities and addressing mental health issues could reduce the events. Our study has some limitations. Although it is an observational study, the sample size is small. We could not discuss the difference between suicide attempts versus self-injurious behaviors like cutting. The conclusion was based on the limited evidence that we got from admitted patients with DSP. Therefore, it is probably not the true reflection of the community. Conclusions DSP with various agents including pesticides and sedatives is one of the common medical emergencies in Bangladesh. We often overlook the background psychiatric conditions of the patients, which might drag one to this horrible situation. Psychiatric evaluation should be done in every case of DSP to prevent recurrence. Diagnosing the actual cause and addressing the conditions could save lives. We are grateful to responsible doctors, nurses, staff, patient relatives, and hospital administration for their support while conducting our study. Human Ethics Animal Ethics Consent was obtained or waived by all participants in this study. Ethical review committee of the Sylhet MAG Osmani Medical College, Sylhet, Bangladesh issued approval SOMC/2013/1399 Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. 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