==== Front Sci Rep Sci Rep Scientific Reports 2045-2322 Nature Publishing Group UK London 37393323 37380 10.1038/s41598-023-37380-x Article Spouse’s coping strategies mediate the relationship between women’s coping strategies and their psychological health among infertile couples Reisi Marzie 1 Kazemi Ashraf kazemi@razi.tums.ac.ir 2 Abedi Mohammad Reza 3 Nazarian Naser 4 1 grid.411036.1 0000 0001 1498 685X School of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran 2 grid.411036.1 0000 0001 1498 685X Nursing and Midwifery Care Research Center, School of Nursing and Midwifery, Isfahan University of Medical Sciences, Hezarjerib AV., Isfahan, Iran 3 grid.411750.6 0000 0001 0454 365X Counseling Department, School of Psychology and Education Sciences, University of Isfahan, Isfahan, Iran 4 grid.411750.6 0000 0001 0454 365X Social Sciences Department, University of Isfahan, Isfahan, Iran 1 7 2023 1 7 2023 2023 13 106754 1 2023 21 6 2023 © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/ Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Social problems and suffering from the treatment process for infertile couples, especially for women, require the couples to cope with them to balance the infertility crisis. According to the close interactions of the couples with each other, the objective of the present study was to explore a theoretical framework for the relationships between women’s coping strategies, spouses’ coping strategies, and women’s psychological health in infertile couples who were candidates for assisted reproductive technology (ART). This cross-sectional study was carried out on 212 couples undergoing ART. The couples’ coping strategies were evaluated using a validated self-report questionnaire. The women’s psychological health was assessed using a 21-item stress, anxiety, and depression scale (DASS-21). Statistical analysis was performed using the plug-in application PROCESS macro for SPSS. The direct effect of the women’s self-blame and self-focused rumination strategies (p < .0001), and the indirect effect of the women’s self-blame on stress and depression by mediating spouses’ self-blame and self-focused rumination strategies, was significant. The indirect effect of the women’s self-focused rumination on the anxiety and depression levels by mediating spouses’ self-blame strategy was significant. The women’s self-blame and self-focused rumination strategies had a negative effect on the women’s psychological health who were undergoing ART. This negative effect was mediated by the spouse’s coping strategies. Subject terms Patient education Psychology Health care Isfahan University of Medical Sciences396703 Kazemi Ashraf issue-copyright-statement© Springer Nature Limited 2023 ==== Body pmcIntroduction Infertility, with a prevalence of approximately 15%1, encounters couples with numerous social problems, such as the increased probability of domestic violence2,3, divorce4, polygyny in some countries5, social isolations6,7, and reduced life quality of infertile couples8. Infertility may affect a couple's mental health9,10; however, assisted reproductive technology (ART) procedures, such as ovarian induction, receiving eggs, and embryo transfer, are mainly carried out on women and expose them to the resulting complications11. Therefore, injuries from these treatments and the adverse psychological effects of infertility and its treatment are more prevalent in women than in men12. Moreover, infertility is often attributed to women13: therefore, women are under social pressure for infertility more than men3,14. Although using an ART has apparent successes, suffering from infertility stigma4,13, stress from ART processes8,9, and the probability of treatment failure have turned infertility into a crisis. Preventing the negative psychological effects of infertility on women requires balancing the crisis by using effective and efficient coping strategies among infertile couples15. Coping strategies are ways an individual employs to manage life crises and include focusing on the problem or the emotions16; however, maladaptive coping strategies may not positively affect psychological health in couples who undergo ART17,18. The association between the anxiety level in women undergoing infertility treatment and maladaptive coping strategies has been previously reported. Peloquin et al. reported that the self-blame strategy predicted anxiety and depression symptoms in both men and women19. However, one study showed that self-blame in women was related to higher marital quality and psychological health20,21. Infertility experiences accompanying stigma and social suffering4,13, that provide the field for selecting the coping strategy may explain these differences. It is believed that the severity of the socio-psychological burden of infertility depends on the importance of fertility in the social context8,22. Zurlo et al. believe that the adequacy of coping strategies in modifying the crisis is situation-dependent. They reported that, against all odds, the problem-oriented coping strategy intensified the effect of problem-solving on the adverse effects of social anxiety18. These contradictory results might originate from ignoring interdependence in the dyadic relationships of infertile couples since the way each couple manages infertility affects their marital relationship23. The shared nature of the infertility experience raises the probability of a correlation between the coping strategies of each infertile couple and its impact on their mental health. Identifying the interactive effect of coping strategies in couples is essential for developing counseling programs for women undergoing infertility treatment. Therefore, the aim of this study was to explore a theoretical framework for the relationships between women’s coping strategies, spouses’ coping strategies, and women’s psychological health in infertile couples who were candidates for ART. The study hypotheses were: (1) women’s coping strategies may influence their spouse’s coping strategies, (2) women’s coping strategies may influence their psychological health, and (3) spouses’ coping strategies may mediate the relationship between women’s coping strategies and psychological health. Materials and methods This cross-sectional study was conducted on 212 couples under ART in the Iran-Isfahan infertility center from January 2019 to May 2019. The study was reviewed and approved by the Ethics Committee of Isfahan University of Medical Sciences (IR.MUI.NUREMA.REC.1400.019). The sample size was calculated considering the confidence coefficient of 95% (1.96) and test power of 80% (0.84). During calculation, the correlation coefficient between the coping strategy score and mental health variables was considered 0.2. The number of samples was calculated as 190 couples, which increased to 212, considering the potential 10% sample attrition. The following formula was used to estimate the number of samples: n = [(z1 + z2)2 (1 − r2)/r2] + 2. The inclusion criteria included using one’s own oocyte for ART and stressful crises based on Holmes- Rahe-Stress-Scale. Convenience sampling was performed for the ART candidate couples before starting the ovarian stimulation protocol. A preliminary interview was implemented, and invited couples were ensured that their participation or non-participation would not affect their treatment process and that their information would be completely confidential. They were then provided with the necessary explanations about the study objectives, and informed consent was obtained from the eligible couples. Inclusion criteria included using the information recorded in the couple’s file and completing the Holmes Rahe scale as a self-report. Only couples who both agreed to enter the study and complete the questionnaires were included in the study. A total of 230 couples were invited to participate in the study by one of the researchers while visiting the infertility center and receiving ovulation stimulation drugs; 212 couples accepted to participate. Instruments The couple coping strategies and women’s psychological health were assessed using self-report questionnaires. The coping strategies were evaluated using a 20-item scale developed using two questionnaires24,25. This questionnaire was designed on a Likert scale from rarely (1) to frequently (4), with five domains including self-blame (4 items), self-focused rumination (4 items), goal replacement (4 items), avoidance (4 items), and active confronting (4 items) strategies. The reliability of the instrument was measured using a pilot study on 15 eligible couples via a retest method with 3-week intervals. The intra-class correlation was calculated to determine the stability of the questionnaire. Internal reliability of the questionnaire with Cronbach’s alpha of 0.86 and repetition with an Intra-Cluster correlation index of 0.72 was confirmed. As the psychological health variables, the levels of depression, anxiety, and stress in women were evaluated using a 21-items depression, anxiety, and stress scale (DASS-21) with Cronbach’s alpha of 0.0.77 for depression, 0.79 for anxiety, and 0.78 for stress26. Statistical analysis Data analysis was performed using SPSS software (version 19) and plug-in application PROCESS macro v 3.4 by Hayes. The linear regression was used to investigate the relationship between women’s and their spouses’ coping strategies and women’s depression, anxiety, and stress levels. To determine the potential confounding variables, Pearson and Spearman correlation coefficients were used, and variables correlated with women’s depression, stress, anxiety, and coping strategies entered the regression model as covariant. The statistical significance of the mediating variable (spouses’ coping strategies) was examined over 10,000 bootstrap samples. This method generated an estimate of the indirect effect, including 95% confidence intervals. When zero was not within the 95% confidence limits, it was concluded that the indirect effect was significantly different from zero. Ethics approval and consent to participate All procedures performed on participants were in accordance with the ethical standards of the Isfahan University of Medical Sciences, and informed consent was obtained from all participants. Results Data analysis was performed on 212 couples with 100% participation. The results showed that participants’ mean (standard deviation) of infertility duration was 6.0 (4.3) years. In 107 (50.47%) couples, the main cause of infertility was the female factor; in 80 (37.74%), it was the male factor. Twenty-five (11.79%) couples had unexplained infertility. The couples’ profiles and the level of their coping strategies are shown in Table 1.Table 1 Demographic characterizes and main variables. Mean (SD) or number (%) Women Spouses Number 212 212 Age 32.2 (4.8) 36.6 (5.0) Educational level (%)  Less than high school 23 (11.3) 30 (14.1)  High school diploma 157 (74.1) 161 (76.0)  University degree 31 (14.6) 21 (9.9) Coping strategies  Self-blame 8.3 (3.4) 7.1 (3.2)  Self-focused rumination 10.4 (3.9) 8.5 (3.5)  Goal replacement 10.2 (3.5) 10.8 (3.3)  Avoidance 10.1 (3.1) 10.3 (3.0)  Active confronting 8.4 (3.4) 7.0 (3.1) Psychological health  Depression 10.7 (5.7) –  Anxiety 9.9 (3.3) –  Stress 14.0 (5.6) – SD standard deviation. Assessments of correlation coefficients (Pearson and Spearman correlation coefficient) showed that the women’s coping strategies were associated with their age, education level, infertility factor, and infertility duration (the results were not presented); therefore, these variables entered the regression model as covariant variables. Independent of potential confounders, the spouses’ self-blame and self-focused rumination strategies were related to the women’s self-blame and self-focused rumination strategies. Moreover, avoidance strategy in men was related to the women’s self-focused rumination strategies (Table 2).Table 2 The relation between partners’ coping strategies (212 couples). Spouse’s coping strategy (CS) Self-blame Self-focused rumination Goal replacement Avoidance Active confronting Beta CI 95% Beta CI 95% Beta CI 95% Beta CI 95% Beta CI 95% Age .01 − .01 .02 .01 − .01 .02 .13 − .02 .19 − .02 − .01 .005 − .11 − .01 .03 Education level .04 − 03 .04 .02 − .04 .04 − .04 − .07 .15 .15 − .01 .05 − .09 − .06 .02 Duration of Infertility − .06 − .03 .02 − .01 − .02 .04 − .10 − .18 .31 .04 − .02 .01 − .05 − .01 .08 Male factor infertility .02 − .05 .08 .03 − .05 .10 .24* .09 .34 .06 − .04 .07 .09 − .11 .34 Female factor infertility .03 − .02 .06 .01 − .02 .04 .11 − .04 .22 .21* .11 .34 .03 − .01 .05 Unexplained infertility .01 − .06 .05 .07 − .03 .11 .09 − .11 .19 .05 − .03 .06 .01 − .02 .03 Women’s CS  Self− blame .25* .13 ..29 .30** .17 .41 − .14 − .16 .11 − .11 − .10 .02 − .03 − .27 .19  Self− focused rumination .32** .12 .53 .25* .12 .44 .12 − .05 .32 .37** .13 .47 − .02 − .27 .23  Goal replacement .07 − .02 .11 − 17 .11 − .02 .11 − .02 .23 .02 − .14 .17 − .05 − .28 .14  Avoidance .11 − .02 .15 .09 − .05 .23 .09 − .01 .32 .05 − .14 .23 − .11 − .12 .09  Active confronting .12 − .09 .18 .03 − .21 .15 − .09 − .12 .11 39 − .12 .17 .11 − .02 .23 CS copping strategies. *p < 0.05; **p < .01; ***p < .001. Significant values are in bold. The anxiety and stress levels were related to the women’s active confronting strategy. The relationships between age and educational level and depression, anxiety, and stress levels were significant. Independent of potential confounders, the depression, anxiety, and stress levels were positively related to women’s self-blame and self-focused rumination strategies and negatively related to women’s goal replacement strategy (Table 3). Evaluation of the relationship between spouses' coping strategies and women's psychological health showed that independent of potential variables, depression, anxiety, and stress levels were positively related to the spouses’ self-blame and self-focused rumination strategies (Table 4).Table 3 The relation between women’s coping strategies and women’s psychological symptoms (212 women). Depression Anxiety Stress R2Adj = .29 p < .0001, F = 10.79 R2Adj = .24 p < .0001, F = 5.28 R2Adj = .30 p < .0001, F = 8.48 Beta Sig CI 95% Beta Sig CI 95% Beta Sig CI 95% Age − .6 ns − .41 .19 − .13 ns − .53 .04 − .06 ns − .42 .15 Education level − .13 ns − 2.32 .11 − .09 ns − 1.92 .40 − .08 ns − 1.82 .48 Duration of Infertility − .10 ns − 3.23 .49 − .03 ns − 2.18 1.37 − .09 ns − 3.04 .49 Male infertility − .12 ns − 6.54 .41 − .6 ns − 4.75 1.90 − .15 .03 − 7.10 − .48 Female infertility − .12 ns − 6.45 .25 − .03 ns − 3.66 2.27 − .08 ns − 4.84 1.06 Unexplained infertility − .01 ns − 4.11 3.61 − .01 ns − 3.99 3.17 .01 ns − 3.65 3.69 Coping strategy  Self-blame .32  < .0001 .59 1.40 .27  < .0001 .37 1.14 .25  < .0001 .39 1.22  Self-focused rumination .17 .007 .13 .83 .19 .004 .16 1.52 .50 .006 .14 .85  Goal replacement − .20 .004 − 1.02 − .19 − .16 .04 − .05 − .11 − .18 .01 − .95 − .12  Avoidance .04 ns − .34 .61 .07 ns − .21 .67 .01 ns − .47 .48  Active confronting .13 ns − .40 .80 .15 .04 .03 .81 1.25 .003 .22 1.06 CSs coping strategies, ns non-significant. Significant values are in bold. Table 4 The relation between spouse’s coping strategies (CSs) and women’s psychological symptoms (212 couples). Depression Anxiety Stress R2Adj = .19 p < .0001, F = 4.29 R2Adj = .19 p < .0001, F = 3.96 R2Adj = .17 p < .0001, F = 4.25 Beta sig CI 95% Beta sig CI 95% Beta sig CI 95% Age − .18 .01 − .70 − .08 − .24 .001 − .76 − .19 − .19 .008 − .75 − .12 Education level − .17 .02 − 2.83 − .24 − .17 .03 − 2.48 − .13 − .18 .02 − 3.55 − .33 Duration of Infertility − .03 ns − .29 .44 .06 ns − .20 .47 − .02 ns − .32 .41 Male infertility − .13 ns − 6.54 .41 − .12 ns − 6.06 .77 − .20 .01 − 8.71 − 1.19 Female infertility − .13 ns − 6.06 .37 .02 ns − 3.05 2.79 − .08 ns − 5.34 1.63 Unexplained infertility .04 ns − 3.45 5.83 .04 ns − 2.48 5.36 .06 ns − 2.52 6.89 Spouse’s CSs  Self-blame .18 .03 .05 1.13 .18 .03 .05 1.02 .17 .03 .04 1.05  Self-focused rumination .18 .04 .02 1.02 .22 .02 .09 1.01 .19 .04 .03 1.07  Goal replacement .06 ns − .27 .64 .09 ns − .17 .66 .08 ns − .22 .71  Avoidance − .01 ns − .34 .61 − .01 ns − .39 .34 .02 ns − .47 .58  Active confronting − .03 ns − .61 .44 − .07 ns − .71 .25 − .04 ns − .64 .44 CS coping strategies, ns non-significant. Significant values are in bold. The total and direct effects of the women’s self-blame and self-focused rumination strategies on the women’s depression (Fig. 1), anxiety (Fig. 2), and stress (Fig. 3) levels were significant. The indirect effects of the women's self-blame strategy on depression, anxiety, and stress levels were mediated by spouses’ self-blame and self-focused rumination strategies. The indirect effects of the women’s self-focused rumination strategy on depression and anxiety levels were mediated by spouses’ self-blame strategy. In addition, the effect of the women’s self-focused rumination strategy on their anxiety level was mediated by spouses’ self-focused rumination strategy. The interaction between couples’ self-focused rumination strategy was significant (Table 5).Figure 1 Mediation by spouse’s coping strategy of the association between women’s coping strategy and depression score. Figure 2 Mediation by spouse’s coping strategy of the association between women’s coping strategy and anxiety score. Figure 3 Mediation by spouse’s coping strategy of the association between women’s coping strategy and stress score. Table 5 Indirect effects of women’s coping strategies on psychological symptoms by mediating spouse’s coping strategies and interaction between couple’s strategies (212 couples). Indirect effects Product of confidents Bootstrapping Women’s CSs Spouses’ CSs Symptom Point Estimate SE 95% CI Interaction Lower Upper F sig Self-blame  →  Self-blame  →  Depression .157* .077 .032 .333 .26 ns Self-blame  →  Self-focused Rumination  →  Depression .154* .075 .032 .333 .34 ns Self-focused Rumination  →  Self-blame  →  Depression .120* .006 .001 .023 2.68 ns Self-focused Rumination  →  Self-focused Rumination  →  Depression .113 .065 − .001 .025 6.59 .01 Self-blame  →  Self-blame  →  Anxiety .151* .077 .025 .325 .66 ns Self-blame  →  Self-focused Rumination  →  Anxiety .154* .069 .038 .306 .86 ns Self-focused Rumination  →  Self-blame  →  Anxiety .114* .060 .009 .247 6.60 .01 Self-focused Rumination  →  Self-focused Rumination  →  Anxiety .112* .058 .014 .240 7.65 .006 Self-blame  →  Self-blame  →  Stress .155* .080 .027 .335 .17 ns Self-blame  →  Self-focused Rumination  →  Stress .160* .076 .032 .338 .35 ns Self-focused Rumination  →  Self-blame  →  Stress .089 .054 − .015 .218 1.09 ns Self-focused Rumination  →  Self-focused Rumination  →  Stress .085 .060 − .022 .215 4.58 .03 CSs coping strategies, SE standard error, CI confidence interval. *Significant. Significant values are in bold. Discussion The present study aimed to evaluate coping strategies’ interactive effect on women’s mental health in couples undergoing ART. The results showed that couples interacted with each other using the self-focused rumination strategy, and the spouse’s use of self-focused rumination and self-blame strategies mediated the effect of self-blame and self-focused rumination strategies on women’s depression, anxiety, and stress levels. The first finding of the study revealed that self-blame and self-focused rumination coping in men was dependent on self-blame and self-focused rumination coping in women. Moreover, men’s avoidance coping was positively related to women’s self-focused rumination coping. Ozkan et al. reported that men and women used similar coping strategies for infertility27. Regarding gender differences in dealing with infertility, Alosaimi et al. reported that in Saudi Arabia, women and men faced different stress types due to infertility and used dissimilar methods to cope with them28. In evaluating the relationship between the coping strategies of each spouse on women’s mental health, this study’s results indicated that women’s depression, anxiety, and stress levels had a positive correlation with the use of self-blame and self-focused rumination strategies. In addition, frequent use of the active confronting strategy was associated with increased anxiety and stress levels. However, the goal replacement strategy used by the women had an inverse relationship with depression, anxiety, and stress levels. Moreover, these strategies’ negative impact on women’s mental health was mediated by men’s use of self-blame and self-focused rumination strategies. The negative impact of infertile women’s maladaptive coping strategies on their depression and anxiety has already been reported18,29. Mirzaasgari et al. reported the relationship between self-blame strategy and rumination with anxiety and depression in women undergoing assisted reproductive treatments. However, unlike the results of the present study, in their study, goal replacement and active confronting strategies had an inverse relationship with the level of stress, anxiety, and depression30. Peloquin reported higher levels of anxiety and depression in women who used the self-blame strategy more than others. This study also reported that the self-blame strategy in men was associated with less satisfaction with married life19. Another study reported higher suicidal thoughts and attempts in women who used the self-blame strategy31. Similarly, Zurlo et al. reported that the self-focused rumination strategy in infertile couples was associated with emotional problems and signs of depression32. These studies reveal the negative impact of using these strategies on women’s mental health. While confirming the results of mentioned studies, the present study showed that the effect of the spouse’s maladaptive coping strategies mediated the negative effects of using these strategies by women. The positive relationship observed between women’s active confronting strategy and their anxiety and stress levels confirms the results of studies showing that in uncontrollable crises such as infertility, this strategy is ineffective in modifying the crisis33. Contrary to this finding, Khalid et al. reported that active coping was inversely related to distress in infertile women34. The contradictions in the results of this study might be related to the infertility taboo in some societies. The expression of feelings and infertility issues, which requires the disclosure of infertility, may be associated with tolerating the infertility taboo in these communities. On the other hand, it is probable that individuals with higher stress and anxiety levels will broadly use this strategy compared to others, which could not be evaluated in the present study and requires prospective studies. The observed inverse relationship between women’s use of goal replacement strategy and the level of their psychological symptoms confirms the results of a study reporting that women undergoing ART had modified the infertility crisis by setting new life goals35. Another study finding showed that, unlike couples’ self-focused rumination strategy, women’s self-blame strategy did not interact with the couple’s coping strategies. This finding could be explained in the traditional context of the society under investigation. In traditional societies such as Iran, women are primarily regarded as responsible for infertility4, and the acceptance of this issue by the couple can cause the husband to disregard the self-blame strategy while the wife uses it. Other studies have likewise shown that in traditional societies, women use the self-blame strategy against infertility more than men20,21 and attribute the responsibility of infertility to them36. Another study has similarly shown a positive relationship between women’s use of this strategy and marital satisfaction23. Another finding of the present study indicated that, although couples’ use of self-blame strategy did not interact with each other, the indirect effect of women’s self-blame and self-focused rumination strategies was mediated by self-blame strategy, similar to self-focused rumination. This finding reveals that in order to improve the mental health of women undergoing ART, it is essential to emphasize spouses’ avoidance of maladaptive strategies such as self-blame and self-focused rumination. In addition, this finding confirms the results of Casu et al.’s study, which showed that the effect of couples’ social support was mediated by their coping strategies37. Zurlo et al. likewise reported that couples’ dynamic interaction was a significant predictor of infertile women’s mental health38. Renzi et al. similarly showed that men’s higher capability to identify and describe their emotions was associated with their wives’ higher quality of life39. It is believed that in dynamic interaction, it is indispensable for couples to make an effort to reduce their partner’s stress by using appropriate strategies40. In addition to confirming this recommendation, the results of the present study emphasize that it is required for infertile couples not to share maladaptive coping strategies. This study showed that the mental health of women undergoing ART is correlated with the couples’ coping strategies. However, the limitations of the present study should be taken into account in the interpretation of the results. The first limitation of the present study was its cross-sectional nature, which reduces the strength of the causal relationship between couples’ coping strategies and women’s mental health. Moreover, men’s mental health status may influence this interactive cycle, and it is suggested to be considered in future studies. This study was conducted on infertile couples undergoing ART, and its results cannot be generalized to those frustrated with their infertility treatment or who do not intend to continue treatment. Furthermore, the generalizability of the study results to couples in the early stages of infertility treatment who have not yet entered the ART process is under question. Furthermore, considering that the inclusion criteria was the participation of both individuals, the results cannot be generalized to couples who did not accompany each other to receive the protocol. In conclusion, this study showed that women’s self-blame and self-focused rumination strategies directly affect their mental health. These strategies have indirect harmful effects by mediating spouses’ self-blame and self-focused rumination strategies. Besides, the negative effects of infertility on the mental health of women undergoing treatment are mediated by their goal replacement strategy. This study confirms the interactive effect of couples’ coping on women's health, and it is suggested that its results be used in developing counseling programs focused on couples. Based on the present study, it is recommended that couples’ avoidance of maladaptive strategies be accentuated in the mental health promotion programs for women undergoing ART. Based on this study results, it is suggested that the coping strategies of couples undergoing infertility treatment be evaluated to notify men of the possible impact of their coping behaviors on their wives’ mental health. Moreover, men should be advised to avoid self-blame and rumination strategies in order to maintain their spouse’s mental health. Acknowledgements The authors gratefully acknowledge the Institutional Review Board affiliated with Isfahan University of Medical Sciences that supported financially this research project. Author contributions M.R and A.K. wrote the main manuscript text. A.K. involved in data collection supervising, acquisition of analysis, interpretation of data, and editing the manuscript. M.RA. and N.N. involved in designing the intervention, interpretation of data, and editing the manuscript. All authors reviewed the manuscript. Funding This study was supported by Isfahan university of Medical Sciences (Grant Number: 396703). Data availability Data and material are available on request from the corresponding author. Competing interests The authors declare no competing interests. Publisher's note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. ==== Refs References 1. Kazemijaliseh H Ramezani Tehrani F Behboudi-Gandevani S Hosseinpanah F Khalili D Azizi F The prevalence and causes of primary infertility in Iran: A population-based study Glob. J. Health Sci. 2015 7 6 226 232 10.5539/gjhs.v7n6p226 26153187 2. Stellar C Garcia-Moreno C Temmerman M van der Poel S A systematic review and narrative report of the relationship between infertility, subfertility, and intimate partner violence Int. J. Gynaecol. 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