==== Front Cardiovasc Diabetol Cardiovasc Diabetol Cardiovascular Diabetology 1475-2840 BioMed Central London 37386419 1893 10.1186/s12933-023-01893-6 Research Triglyceride glucose index is a significant predictor of severe disturbance of consciousness and all-cause mortality in critical cerebrovascular disease patients Chen Ting ggcfcmdxdynyzq@gmail.com 1 Qian Yuan yuanqian2x@hotmail.com 2 Deng Xingli dxlkmmu@163.com 134 1 grid.414902.a 0000 0004 1771 3912 Department of Neurosurgery, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650032 China 2 Clinical Medical Research Center for Obstetrics and Gynecology (Yunnan Joint Key Laboratory), Kunming city of Maternal and Child Health Hospital,Kunming city of Women and Children Hospital, Kunming, Yunnan 650032 China 3 grid.411634.5 0000 0004 0632 4559 Puer People’s Hospital, Puer, Yunnan 665099, China 4 Yunnan Provincial Clinical Research Center for Neurological Disease, Kunming, Yunnan, 650032 China 29 6 2023 29 6 2023 2023 22 15610 4 2023 17 6 2023 © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/ Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. Objective The association of the triglyceride-glucose (TyG) index with severe consciousness disturbance and in-hospital mortality in patients with cerebrovascular disease in the intensive care unit (ICU) is unclear. This study aimed to investigate the TyG index’s predictive ability on the severity of impaired consciousness and in-hospital mortality in patients with cerebrovascular disease in the ICU. Method Patients diagnosed with non-traumatic cerebral hemorrhage and cerebral infarction were extracted from the MIMIC-IV database and analyzed as two cohorts. The association between the TyG index and the severity of patients’ impairment of consciousness and in-hospital mortality was analyzed using logistic regression models. Using restricted cubic spline curves, we analyzed potential nonlinear relationships between TyG indices and outcome indicators. receiver operating characteristic (ROC) curves were utilized to evaluate the predictive ability of the TyG index for outcome indicators. Result The study’s last two cohorts comprised 537 patients with traumatic cerebral hemorrhage and 872 patients with cerebral infarction. TyG index was a significant predictor of the severity of impaired consciousness and in-hospital mortality in patients with cerebrovascular disease, as determined by logistic regression. The risk of severe consciousness impairment and in-hospital mortality increased roughly linearly with increasing TyG index. Conclusion The TyG index was found to be a significant predictor for severe impairment of consciousness and in-hospital death in patients with cerebrovascular disease in the ICU, and it provides some predictive value for the severity of consciousness disturbances and in-hospital mortality in cerebrovascular disease patients. Keywords TyG index Cerebral infarction Non-traumatic cerebral hemorrhage ICU MIMIC database Yunnan Province’s "Ten Thousand People Plan" Young Top Talent Special Provincial Basic Research Program202101AY070001-017 issue-copyright-statement© BioMed Central Ltd., part of Springer Nature 2023 ==== Body pmcBackground Cerebrovascular disease remains a significant cause of the global disease burden [1]. Most patients who survive a cerebrovascular event suffer from disabilities and nerve damage and are at high risk for recurrent cerebrovascular events, and declining cognitive, and systemic vascular disease [2, 3]. Cerebrovascular disease patients admitted to the intensive care unit (ICU) frequently have more severe disorders of consciousness, a more complicated condition, and a higher mortality rate [4]. Insulin resistance (IR), defined as a decrease in the efficiency of insulin to promote glucose uptake and utilization, is a prominent feature of the metabolic syndrome [5] and has an impact on multiple organs’ metabolic signaling pathways [6]. Triglyceride-glucose (TyG) index has become a substitute marker for IR. Several studies have revealed the relevance of the TyG index and cardiovascular disease. A higher TyG index is linked to an increased risk of cardiovascular events, cerebrovascular events, and kidney microvascular damage [7–9], as well as inflammation, endothelial dysfunction, oxidative stress, and prothrombotic state [10, 11]. There are also studies demonstrating the prognostic value of the TyG index in heart failure and severe illnesses [12]. There are currently no studies that directly illustrate the connection between IR and disturbance consciousness. Nonetheless, several pathophysiological processes may explain the potential effects of IR on brain. Metabolic disturbances can result in hyperviscosity and an increase in the brain’s water content, leading to a decrease in cerebral blood flow and intracellular acidosis [13–15]. It has also been demonstrated that increased nitrogen waste in the brains of hyperglycemic patients may cause toxic and metabolic damage to brain tissue, particularly the basal ganglia, affecting focal cellular metabolism and leading to cellular edema while increasing the permeability of the blood-brain barrier. The severity of the symptoms ranges from mild (drowsiness) to severe (coma)[16, 17]. Taken together, we can hypothesize that IR exacerbates the disturbance of consciousness or increases the mortality rate of critical patients with cerebrovascular disease. As an alternative index of IR, the TyG index may be helpful for predicting patients’ consciousness disturbance and mortality. However, the validity of this hypothesis is unclear. Therefore, this study aimed to examine whether the TyG index can be used as a predictor of severe disturbance of consciousness and in-hospital mortality in patients with non-traumatic cerebral hemorrhage and cerebral infarction in the ICU. This may help to distinguish patients at higher risk for more close monitoring or early intervention. Method Study population The original data were derived from the MIMIC-IV database. The MIMIC-IV database is a comprehensive single-center database maintained by the Massachusetts Institute of Technology Lab for Computational Physiology [18]. The author (Ting Chen) was granted access to the dataset (ID: 10,946,391) and is responsible for data extraction. Inclusion criteria: a diagnosis of non-traumatic cerebral hemorrhage or cerebral infarction (based on the International Classification of Diseases, Ninth Revision (ICD-9), or International Classification of Diseases, Tenth Revision (ICD-10)). Exclusion criteria: (a) not admitted to an ICU, (b) missing triglyceride and glucose data, (c) severe disorders of consciousness prior to hospital admission (Glasgow coma scale score < 8), (d) follow-up time less than 1 day. For patients with multiple admissions, we chose the last admission. Patient characteristics Structured query language (SQL) was used to extract demographic information, laboratory indicators, comorbidities, intra-hospital mortality, and scores from the MIMIC-IV database. Demographic information included gender, age, race, and body mass index (BMI). Laboratory indicators included triglyceride, glucose, creatine phosphokinase (CPK), creatine kinase isoenzyme MB (CKMB), lactate dehydrogenase (IDH), alkaline phosphatase (ALP), aspartate aminotransferase (AST), international normalized ratio (INR), alanine aminotransferase (ALT), creatinine, prothrombin Time (PT), active partial thromboplastin time (PTT), glycated hemoglobin A 1c (HbA 1c). Comorbidities and personal history of patients were identified based on ICD-9 and ICD-10, including anemia, cancer, chronic kidney disease (CKD), hyperlipidemia, diabetes, hypertension, respiratory failure, long-term use of antiplatelet agents/anticoagulants, alcohol abuse, and tobacco use. Scores include Glasgow coma scale (GCS) score, acute physiology score III (APSIII), oxford acute severity of illness score (OASIS) and simplified acute physiology score (SAPSII). TyG index was calculated according to the formula: ln [fasting triglycerides (mg/dL) × fasting glucose (mg/dL)]/2. For laboratory indicators that were measured multiple times within 24 h of admission, the first measurement was used in this study. To reduce reverse causation bias, data that were collected after the outcome events were deemed invalid. Missing values for laboratory indicators are common in the MIMIC-IV database. To reduce the bias caused by sample exclusion, we calculated the percentage of missing values for each continuous variable. For variables with a missing value share of less than 20%, we predicted the missing values using a random forest-based multiple imputation method, predicting five outcomes, and calculating the mean of the five outcomes as the final result. For variables with missing value proportion greater than 20%, we classified the missing values. For non-normally distributed continuous variables, we analyzed them after converting them into categorical variables according to the normal reference range provided by the MIMIC-IV database. Outcome measures The primary outcome indicator was the occurrence of severe impairment of consciousness, defined as a GCS score of less than 8, within 30 days of patient admission. the secondary outcome indicator was the patient’s in-hospital mortality within 30 days. Statistical analysis Continuous variables are presented as the mean (standard deviation (SD)) or median (interquartile range, (IQR)), and were compared using a student t-test or a nonparametric test, as appropriate. Categorical variables are presented as frequencies and percentages (%) and were compared between groups using the Pearson chi-square test or Fisher’s exact test. Logistic regression models were used to estimate odds ratios (ORs) and their 95% confidence intervals (95% CIs) and adjusted for several confounding variables (model 1: unadjusted; Model 2: adjusted for age, sex, BMI, and race; model 3: adjusted for age, sex, BMI, race, CPK, CKMB, IDH, ALP, AST, INR, ALT, creatinine, PT, PTT, HbA 1c, anemia, cancer, CKD, hyperlipemia, hypertension, respiratory failure, diabetes, alcohol abuse, long-term use of antiplatelet agents/anticoagulants, tobacco use.). To examine the incidence of outcome events according to various levels of the TyG index, we included TyG index segments as categorical variables according to quartiles in the model (the lowest quartile of TyG index values was used as the reference group). To prevent multicollinearity, variables having a variance inflation factor of more than 5 were excluded from the model. Potential nonlinear correlations between TyG index levels and outcomes were investigated utilizing restricted cubic splines. The area under the ROC curve (AUC) was calculated to evaluate the predictive ability of the numerical- and categorical-type TyG index individually. Clinical decision curves were plotted, and the integrated discrimination improvement (IDI) were calculated separately in order to assess the improvement in the predictive ability and clinical value of scoring tools resulting from the incorporation of TyG indices. Two-tailed P values < 0.05 were considered statistically significant, and all statistical analyses were performed using the R language (R version 4.2.2). Result Study population characteristics A total of 1409 patients were enrolled in the present study (537 patients with non-traumatic cerebral hemorrhage and 872 patients with cerebral infarction). The patient selection process is outlined in Fig. 1. The median age of patients in both groups was 71 years. There were 293 (54.6%) men and 244 (45.4%) women with non-traumatic cerebral hemorrhage, of which 48 (8.9%) developed severe disturbance of consciousness and 99 (18.4%) died in the hospital (Table 1). There were 430 (49.3%) males and 442 (50.7%) females with cerebral infarction, a total of 161 (18.5%) with severe disturbance of consciousness, and 129 (14.8%) in-hospital deaths (Table 2). Patients with non-traumatic cerebral hemorrhage and patients with cerebral infarction were described based on the admission TyG index quartiles (Tables 1 and 2). Fig. 1 Flowchart of patient selection Table 1 All characteristics of patients with nontraumatic cerebral hemorrhage Characteristics Overall Q1 Q2 Q3 Q4 P n 537 135 135 134 133 In-hospital death = Yes (%) 99 (18.4) 12 (8.9) 24 (17.8) 18 (13.4) 45 (33.8) < 0.001 Hospital stays (day) 8.00 [4.00, 16.00] 7.00 [4.00, 12.00] 8.00 [4.00, 13.50] 8.00 [5.00, 17.00] 10.00 [4.00, 22.00] 0.039 GCS score < 8 (%) 48 (8.9) 5 (3.7) 13 (9.6) 11 (8.2) 19 (14.3) 0.025 Follow-up time of GCS score 7.00 [4.00, 14.00] 7.00 [4.00, 11.50] 6.00 [3.00, 12.00] 7.00 [4.00, 15.00] 8.00 [4.00, 19.00] 0.131 Gender = Male (%) 293 (54.6) 67 (49.6) 77 (57.0) 75 (56.0) 74 (55.6) 0.609 Race (%) 0.215  Asian 14 (2.6) 2 (1.5) 3 (2.2) 5 (3.7) 4 (3.0)  Black 51 (9.5) 15 (11.1) 16 (11.9) 10 (7.5) 10 (7.5)  Other 165 (30.7) 31 (23.0) 37 (27.4) 47 (35.1) 50 (37.6)  White 307 (57.2) 87 (64.4) 79 (58.5) 72 (53.7) 69 (51.9) Anemia = Yes (%) 103 (19.2) 18 (13.3) 24 (17.8) 30 (22.4) 31 (23.3) 0.139 Cancer = Yes (%) 42 (7.8) 11 (8.1) 9 (6.7) 10 (7.5) 12 (9.0) 0.906 CKD = Yes (%) 92 (17.1) 17 (12.6) 23 (17.0) 26 (19.4) 26 (19.5) 0.393 Diabetes = Yes (%) 154 (28.7) 17 (12.6) 36 (26.7) 39 (29.1) 62 (46.6) < 0.001 Hyperlipemia = Yes (%) 37 (6.9) 8 (5.9) 9 (6.7) 11 (8.2) 9 (6.8) 0.903 Hypertension = Yes (%) 449 (83.6) 107 (79.3) 121 (89.6) 117 (87.3) 104 (78.2) 0.022 Respiratory failure = Yes (%) 51 (9.5) 9 (6.7) 6 (4.4) 15 (11.2) 21 (15.8) 0.008 Site (%) 0.029  cerebellum 30 (5.6) 9 (6.7) 8 (5.9) 5 (3.7) 8 (6.0)  cortical 121 (22.5) 35 (25.9) 34 (25.2) 27 (20.1) 25 (18.8)  intraventricular 79 (14.7) 17 (12.6) 15 (11.1) 23 (17.2) 24 (18.0)  Other 216 (40.2) 57 (42.2) 62 (45.9) 54 (40.3) 43 (32.3)  subarachnoid 61 (11.4) 6 (4.4) 11 (8.1) 19 (14.2) 25 (18.8)  subdural 30 (5.6) 11 (8.1) 5 (3.7) 6 (4.5) 8 (6.0) Alcohol abuse = Yes (%) 56 (10.4) 10 (7.4) 6 (4.4) 23 (17.2) 17 (12.8) 0.003 Long-term use of antiplatelet agents/anticoagulants = Yes (%) 123 (22.9) 30 (22.2) 36 (26.7) 30 (22.4) 27 (20.3) 0.648 Tobacco use = Yes (%) 6 (1.1) 0 (0.0) 1 (0.7) 3 (2.2) 2 (1.5) 0.333 BMI (%)  < 18 6 (1.1) 1 (0.7) 1 (0.7) 2 (1.5) 2 (1.5) 0.874  > 24 143 (26.6) 41 (30.4) 38 (28.1) 26 (19.4) 38 (28.6) 0.174  18–24 44 (8.2) 17 (12.6) 11 (8.1) 10 (7.5) 6 (4.5) 0.113 CPK (%)  ≤ 130 IU/L 161 (30.0) 44 (32.6) 40 (29.6) 44 (32.8) 33 (24.8) 0.447  > 130 IU/L 171 (31.8) 39 (28.9) 44 (32.6) 35 (26.1) 53 (39.8) 0.089 CKMB (%)  > 5 ng/mL 78 (14.5) 11 (8.1) 17 (12.6) 20 (14.9) 30 (22.6) 0.008  ≤ 5 ng/mL 223 (41.5) 61 (45.2) 60 (44.4) 53 (39.6) 49 (36.8) 0.451 IDH (%)  ≤ 300 IU/L 244 (45.4) 71 (52.6) 63 (46.7) 56 (41.8) 54 (40.6) 0.184  > 300 IU/L 98 (18.2) 15 (11.1) 19 (14.1) 26 (19.4) 38 (28.6) 0.001 CRP (%)  ≤ 5 mg/L 49 (9.1) 18 (13.3) 13 (9.6) 10 (7.5) 8 (6.0) 0.178  > 10 mg/L 69 (12.8) 16 (11.9) 14 (10.4) 17 (12.7) 22 (16.5) 0.478  5–10 mg/L 22 (4.1) 3 (2.2) 10 (7.4) 4 (3.0) 5 (3.8) 0.143 HbA 1c (%) < 0.001  4–6% 334 (62.2) 112 (83.0) 92 (68.1) 79 (59.0) 51 (38.3)  > 6% 203 (37.8) 23 (17.0) 43 (31.9) 55 (41.0) 82 (61.7) Age (%) < 0.001  < 40 years 20 (3.7) 5 (3.7) 3 (2.2) 5 (3.7) 7 (5.3)  ≥ 80 years 131 (24.4) 49 (36.3) 36 (26.7) 26 (19.4) 20 (15.0)  40–59 years 100 (18.6) 20 (14.8) 12 (8.9) 31 (23.1) 37 (27.8)  60–79 years 286 (53.3) 61 (45.2) 84 (62.2) 72 (53.7) 69 (51.9) ALP (%) 0.003  < 40 IU/L 13 (2.4) 4 (3.0) 5 (3.7) 0 (0.0) 4 (3.0)  > 130 IU/L 65 (12.1) 7 (5.2) 14 (10.4) 17 (12.7) 27 (20.3)  40–130 IU/L 459 (85.5) 124 (91.9) 116 (85.9) 117 (87.3) 102 (76.7) AST (%) 0.003  ≤ 40 IU/L 384 (71.5) 110 (81.5) 101 (74.8) 90 (67.2) 83 (62.4)  >40 IU/L 153 (28.5) 25 (18.5) 34 (25.2) 44 (32.8) 50 (37.6) Creatinine (%) 0.007  < 0.5 mg/dL 9 (1.7) 3 (2.2) 1 (0.7) 2 (1.5) 3 (2.3)  > 1.2 mg/dL 108 (20.1) 17 (12.6) 21 (15.6) 29 (21.6) 41 (30.8)  0.5–1.2 mg/dL 420 (78.2) 115 (85.2) 113 (83.7) 103 (76.9) 89 (66.9) INR (%) 0.859  0.9–1.1 285 (53.1) 75 (55.6) 71 (52.6) 72 (53.7) 67 (50.4)  > 1.1 252 (46.9) 60 (44.4) 64 (47.4) 62 (46.3) 66 (49.6) PT (%) 0.094  < 11 s 49 (9.1) 11 (8.1) 7 (5.2) 21 (15.7) 10 (7.5)  > 13 s 183 (34.1) 50 (37.0) 46 (34.1) 40 (29.9) 47 (35.3)  11–13 s 305 (56.8) 74 (54.8) 82 (60.7) 73 (54.5) 76 (57.1) PTT (%) 0.263  < 25 s 81 (15.1) 17 (12.6) 17 (12.6) 20 (14.9) 27 (20.3)  > 37 s 35 (6.5) 13 (9.6) 6 (4.4) 7 (5.2) 9 (6.8)  25–37 s 421 (78.4) 105 (77.8) 112 (83.0) 107 (79.9) 97 (72.9) ALT (%) < 0.001  ≤ 40 IU/L (%) 444 (82.7) 122 (90.4) 119 (88.1) 108 (80.6) 95 (71.4)  >40 IU/L (%) 93 (17.3) 13 (9.6) 16 (11.9) 26 (19.4) 38 (28.6) TyG index: Q1 (7.129–8.378), Q2 (8.378–8.764), Q3 (8.764–9.239), Q4 (9.239–12.102) Table 2 All characteristics of patients with cerebral infarction Overall Q1 Q2 Q3 Q4 P n 872 218 218 218 218 In-hospital death = Yes (%) 129 (14.8) 22 (10.1) 24 (11.0) 32 (14.7) 51 (23.4) < 0.001 Hospital stays (day) 7.00 [4.00, 13.00] 6.00 [3.00, 10.00] 7.00 [4.00, 12.00] 7.00 [4.00, 14.00] 9.00 [4.00, 19.75] 0.001 GCS score < 8 (%) 161 (18.5) 28 (12.8) 40 (18.3) 38 (17.4) 55 (25.2) 0.010 Follow-up time of GCS score 5.00 [3.00, 10.00] 5.00 [3.00, 9.00] 5.00 [3.00, 10.00] 5.00 [3.00, 10.00] 6.00 [3.00, 13.00] 0.216 Gender = Male (%) 430 (49.3) 104 (47.7) 110 (50.5) 110 (50.5) 106 (48.6) 0.92 Race (%) 0.554  Asian 23 (2.6) 4 (1.8) 5 (2.3) 9 (4.1) 5 (2.3)  Black 79 (9.1) 25 (11.5) 17 (7.8) 17 (7.8) 20 (9.2)  Other 273 (31.3) 60 (27.5) 67 (30.7) 69 (31.7) 77 (35.3)  White 497 (57.0) 129 (59.2) 129 (59.2) 123 (56.4) 116 (53.2) Anemia = Yes (%) 208 (23.9) 40 (18.3) 52 (23.9) 58 (26.6) 58 (26.6) 0.141 Cancer = Yes (%) 80 (9.2) 17 (7.8) 24 (11.0) 13 (6.0) 26 (11.9) 0.109 CKD = Yes (%) 156 (17.9) 39 (17.9) 38 (17.4) 30 (13.8) 49 (22.5) 0.128 Diabetes = Yes (%) 303 (34.7) 28 (12.8) 58 (26.6) 79 (36.2) 138 (63.3) < 0.001 Hyperlipemia = Yes (%) 79 (9.1) 16 (7.3) 23 (10.6) 25 (11.5) 15 (6.9) 0.245 Hypertension = Yes (%) 693 (79.5) 162 (74.3) 173 (79.4) 177 (81.2) 181 (83.0) 0.13 Respiratory failure = Yes (%) 88 (10.1) 16 (7.3) 22 (10.1) 20 (9.2) 30 (13.8) 0.154 Site (%) 0.023  Basilar artery 15 (1.7) 1 (0.5) 8 (3.7) 5 (2.3) 1 (0.5)  Bilateral cerebellar artery 11 (1.3) 2 (0.9) 3 (1.4) 3 (1.4) 3 (1.4)  Left anterior cerebral artery 13 (1.5) 5 (2.3) 3 (1.4) 1 (0.5) 4 (1.8)  Left cerebellar artery 15 (1.7) 3 (1.4) 6 (2.8) 4 (1.8) 2 (0.9)  Left carotid artery 27 (3.1) 6 (2.8) 5 (2.3) 9 (4.1) 7 (3.2)  Left middle cerebral artery 160 (18.3) 54 (24.8) 39 (17.9) 37 (17.0) 30 (13.8)  Left posterior cerebral artery 23 (2.6) 4 (1.8) 8 (3.7) 3 (1.4) 8 (3.7)  Other 399 (45.8) 83 (38.1) 93 (42.7) 98 (45.0) 125 (57.3)  Right anterior cerebral artery 4 (0.5) 0 (0.0) 2 (0.9) 2 (0.9) 0 (0.0)  Right cerebellar artery 16 (1.8) 3 (1.4) 3 (1.4) 5 (2.3) 5 (2.3)  Right carotid artery 31 (3.6) 9 (4.1) 7 (3.2) 6 (2.8) 9 (4.1)  Right middle cerebral artery 143 (16.4) 46 (21.1) 35 (16.1) 41 (18.8) 21 (9.6)  Right posterior cerebral artery 15 (1.7) 2 (0.9) 6 (2.8) 4 (1.8) 3 (1.4) Alcohol abuse = Yes (%) 49 (5.6) 9 (4.1) 12 (5.5) 13 (6.0) 15 (6.9) 0.654 Long-term use of antiplatelet agents/anticoagulants = Yes (%) 270 (31.0) 74 (33.9) 71 (32.6) 72 (33.0) 53 (24.3) 0.106 Tobacco use = Yes (%) 18 (2.1) 8 (3.7) 4 (1.8) 2 (0.9) 4 (1.8) 0.23 BMI (%)  < 18 7 (0.8) 2 (0.9) 3 (1.4) 2 (0.9) 0 (0.0) 0.434  > 24 314 (36.0) 80 (36.7) 73 (33.5) 69 (31.7) 92 (42.2) 0.108  18–24 88 (10.1) 29 (13.3) 28 (12.8) 15 (6.9) 16 (7.3) 0.035 CPK (%)  ≤ 130 IU/L 287 (32.9) 65 (29.8) 76 (34.9) 72 (33.0) 74 (33.9) 0.699  > 130 IU/L 211 (24.2) 55 (25.2) 44 (20.2) 57 (26.1) 55 (25.2) 0.454 CKMB (%)  > 5 ng/mL 110 (12.6) 27 (12.4) 23 (10.6) 26 (11.9) 34 (15.6) 0.439  ≤ 5 ng/mL 337 (38.6) 89 (40.8) 90 (41.3) 77 (35.3) 81 (37.2) 0.513 IDH (%)  ≤ 300 IU/L 379 (43.5) 106 (48.6) 102 (46.8) 86 (39.4) 85 (39.0) 0.088  > 300 IU/L 164 (18.8) 21 (9.6) 32 (14.7) 49 (22.5) 62 (28.4) < 0.001 CRP (%)  ≤ 5 mg/L 78 (8.9) 33 (15.1) 18 (8.3) 19 (8.7) 8 (3.7) < 0.001  > 10 mg/L 103 (11.8) 23 (10.6) 31 (14.2) 18 (8.3) 31 (14.2) 0.144  5–10 mg/L 35 (4.0) 8 (3.7) 6 (2.8) 11 (5.0) 10 (4.6) 0.625 HbA 1c (%) < 0.001  4–6% 547 (62.7) 187 (85.8) 158 (72.5) 131 (60.1) 71 (32.6)  > 6% 325 (37.3) 31 (14.2) 60 (27.5) 87 (39.9) 147 (67.4) Age (%) < 0.001  < 40 years 32 (3.7) 10 (4.6) 6 (2.8) 9 (4.1) 7 (3.2)  ≥80 years 233 (26.7) 74 (33.9) 70 (32.1) 59 (27.1) 30 (13.8)  40–59 years 174 (20.0) 31 (14.2) 36 (16.5) 45 (20.6) 62 (28.4)  60–79 years 433 (49.7) 103 (47.2) 106 (48.6) 105 (48.2) 119 (54.6) ALP (%) 0.667  < 40 IU/L 20 (2.3) 6 (2.8) 5 (2.3) 4 (1.8) 5 (2.3)  > 130 IU/L 132 (15.1) 27 (12.4) 31 (14.2) 33 (15.1) 41 (18.8)  40–130 IU/L 720 (82.6) 185 (84.9) 182 (83.5) 181 (83.0) 172 (78.9) AST (%) 0.352  ≤ 40 IU/L (%) 601 (68.9) 160 (73.4) 150 (68.8) 143 (65.6) 148 (67.9)  > 40 IU/L (%) 271 (31.1) 58 (26.6) 68 (31.2) 75 (34.4) 70 (32.1) Creatinine (%) 0.026  < 0.5 mg/dL 10 (1.1) 2 (0.9) 4 (1.8) 3 (1.4) 1 (0.5)  > 1.2 mg/dL 203 (23.3) 43 (19.7) 45 (20.6) 45 (20.6) 70 (32.1)  0.5–1.2 mg/dL 659 (75.6) 173 (79.4) 169 (77.5) 170 (78.0) 147 (67.4) INR (%) 0.795  0.9–1.1 436 (50.0) 109 (50.0) 111 (50.9) 113 (51.8) 103 (47.2)  >1.1 436 (50.0) 109 (50.0) 107 (49.1) 105 (48.2) 115 (52.8) PT (%) 0.46  < 11 s 73 (8.4) 19 (8.7) 19 (8.7) 12 (5.5) 23 (10.6)  > 13 s 352 (40.4) 84 (38.5) 93 (42.7) 95 (43.6) 80 (36.7)  11–13 s 447 (51.3) 115 (52.8) 106 (48.6) 111 (50.9) 115 (52.8) PTT (%) 0.382  < 25 s 100 (11.5) 22 (10.1) 22 (10.1) 28 (12.8) 28 (12.8)  > 37 s 125 (14.3) 24 (11.0) 36 (16.5) 28 (12.8) 37 (17.0)  25–37 s 647 (74.2) 172 (78.9) 160 (73.4) 162 (74.3) 153 (70.2) ALT (%) 0.204  ≤ 40 IU/L (%) 712 (81.7) 185 (84.9) 182 (83.5) 176 (80.7) 169 (77.5)  > 40 IU/L (%) 160 (18.3) 33 (15.1) 36 (16.5) 42 (19.3) 49 (22.5) TyG index: Q1 (7.129–8.428), Q2 (8.428–8.822); Q3 (8.822–9.251); Q4 (9.251–12.102) In-hospital mortality (P < 0.001), length of stay (P = 0.039), and incidence of severe disruption of consciousness (P = 0.025), according to data from patients with non-traumatic cerebral hemorrhage, increased as the TyG index rose. Patients with alcohol abuse had higher levels of TyG index. Patients with higher TyG index levels were more likely to have comorbid conditions like diabetes (P < 0.001), hypertension (P = 0.022), respiratory failure (P = 0.008), as well as higher levels of HbA 1c (P < 0.001), CKMB (P = 0.008), IDH (P = 0.001), ALP (P = 0.003), AST (P = 0.003), creatinine (P = 0.007), and ALT (P < 0.001) (Table 1). Patients with cerebral infarction exhibited a gradual increase in in-hospital mortality (P < 0.001), length of stay (P = 0.001), and incidence of severe disorder of consciousness (P = 0.010) as the level of TyG index increased, as well as a gradual decrease in patients with a normal BMI (18–24 kg/m2) as the level of TyG index increased. Patients with a higher TyG index were younger (P < 0.001), more likely to combine diabetes (P < 0.001), and had higher levels of HbA 1c (P < 0.001), IDH (P < 0.001), and creatinine (P = 0.026) (Table 2). Influence of TyG index on the severity of consciousness disturbance and in-hospital mortality The logistic regression model was used to assess the effect of exposure variables on the outcome measures, adjusting for covariates. (Model 1: unadjusted. Model 2: adjusted for age, sex, BMI, and race. Model 3: adjusted for age, sex, BMI, race, CPK, CKMB, IDH, ALP, AST, INR, ALT, creatinine, PT, PTT, anemia, cancer, CKD, hyperlipemia, hypertension, respiratory failure, diabetes.) Analysis of patients with nontraumatic cerebral hemorrhage showed that in unadjusted (OR [95% CI], 4.33 [1.68, 13.4]. P-value = 0.005), adjusted by demographic information (OR [95% CI], 4.34 [1.63, 13.8], P-value = 0.006) and fully adjusted (OR [95% CI], 3.68 [1.12, 13.8], P-value = 0.040) models, higher TyG index (Q4: 9.239–12.102) patients had a significantly higher risk of severe disturbance of consciousness than those with a lower TyG index (Q1: 7.129–8.378). However, as the model was adjusted, the effect of the TyG index on the severity of consciousness disorder gradually decreased. In addition, the results demonstrated that a higher TyG index was significantly associated with patients’ in-hospital mortality. In unadjusted (Q2: OR [95% CI], 2.22 [1.08, 4.78], P-value = 0.035; Q4: OR [95% CI], 5.24 [2.70, 10.9], P-value < 0.001), adjusted by demographic information (Q2: OR [95% CI], 2.41 [1.15, 5.30]. P-value = 0.023; Q4: OR [95% CI], 5.65 [2.81, 12.2], P-value < 0.001) and fully adjusted (Q2: OR [95% CI], 3.81 [1.57, 9.84], P-value = 0.004; Q4: OR [95% CI], 8.86 [3.49, 24.2], P-value < 0.001) models, patients with a TyG index of Q2 and Q4 had a significantly higher risk of in-hospital death than Q1 (Table 3). Table 3 Logistic regression analysis of consciousness disturbance and in-hospital mortality in cerebrovascular disease patients Factor OR1 95% CI1 P OR1 95% CI1 P OR1 95% CI1 P Model 1 Model 2 Model 3 Severity of consciousness disturbance (patients with non-traumatic cerebral hemorrhage) TyG2 P for trend: 0.074 P for trend: 0.117 P for trend: 0.594  Q1 — — — — — —  Q2 2.77 1.01, 8.84 0.060 2.69 0.97, 8.70 0.072 2.60 0.84, 9.21 0.110  Q3 2.33 0.82, 7.56 0.130 2.04 0.69, 6.83 0.200 1.52 0.44, 5.73 0.500  Q4 4.33 1.68, 13.4 0.005 4.34 1.63, 13.8 0.006 3.68 1.12, 13.8 0.040 Severity of consciousness disturbance (patients with cerebral infarction) TyG3 P for trend: 0.014 P for trend: 0.002 P for trend: 0.168  Q1 — — — — — —  Q2 1.52 0.91, 2.60 0.110 1.54 0.91, 2.65 0.110 1.47 0.82, 2.67 0.200  Q3 1.43 0.85, 2.45 0.200 1.48 0.87, 2.56 0.200 1.15 0.62, 2.14 0.700  Q4 2.29 1.40, 3.82 0.001 2.78 1.66, 4.74 < 0.001 2.48 1.31, 4.74 0.005 In-hospital mortality (patients with non-traumatic cerebral hemorrhage) TyG2 P for trend: <0.001 P for trend: <0.001 P for trend: <0.001  Q1 — — — — — —  Q2 2.22 1.08, 4.78 0.035 2.41 1.15, 5.30 0.023 3.81 1.57, 9.84 0.004  Q3 1.59 0.74, 3.53 0.200 1.72 0.78, 3.91 0.200 2.32 0.90, 6.23 0.085  Q4 5.24 2.70, 10.9 < 0.001 5.65 2.81, 12.2 < 0.001 8.86 3.49, 24.2 < 0.001 In-hospital mortality (patients with cerebral infarction) TyG3 P for trend: <0.001 P for trend: <0.001 P for trend: 0.016  Q1 — — — — — —  Q2 1.1 0.60, 2.04 0.800 1.11 0.59, 2.07 0.700 0.87 0.44, 1.73 0.700  Q3 1.53 0.86, 2.76 0.150 1.63 0.91, 2.98 0.100 1.31 0.67, 2.61 0.400  Q4 2.72 1.60, 4.75 < 0.001 3.06 1.77, 5.47 < 0.001 2.51 1.26, 5.10 0.010 1 OR = Odds Ratio, CI = Confidence Interval 2 TyG index: Q1 (7.129–8.378), Q2 (8.378–8.764), Q3 (8.764–9.239), Q4 (9.239–12.102) 3 TyG index: Q1 (7.129–8.428), Q2 (8.428–8.822); Q3 (8.822–9.251); Q4 (9.251–12.102) Model 1: unadjusted Model 2: adjusted for age, sex, BMI, and race. Model 3: adjusted for age, sex, BMI, race, CPK, CKMB, IDH, ALP, AST, INR, ALT, Creatinine, PT, PTT, HbA1c, anemia, cancer, CKD, hyperlipemia, hypertension, respiratory failure, diabetes, alcohol abuse, long-term use of antiplatelet agents/anticoagulants, tobacco use. Analysis of patients with cerebral infarction showed that high levels of TyG index (Q4: 9.251–12.102) were significantly associated with the severity of consciousness disturbance in unadjusted (OR [95% CI], 2.29 [1.40, 3.82], P-value = 0.001), adjusted by demographic information (OR [95% CI], 2.78 [1.66, 4.74], P-value < 0.001) and fully adjusted (OR [95% CI], 2.48 [1.31, 4.74], P-value = 0.005) models. In addition, in unadjusted (OR [95% CI], 2.72 [1.60, 4.75], P-value < 0.001), adjusted by demographic information (OR [95% CI], 3.06 [1.77, 5.47], P-value < 0.001) and fully adjusted (OR [95% CI], 2.51 [1.26, 5.10], P-value = 0.010) models, patients with high TyG index (Q4: 9.251–12.102) had a significantly higher risk of in-hospital death than patients with low TyG index (Q2: 7.129–8.428) (Table 3). Alternately, we used restricted cubic splines (RCS) to assess possible nonlinearity in the association of the TyG index with outcomes. The result of RCS showed that the P values for nonlinearity for the TyG index outcomes were nonsignificant (P-nonlinear > 0.05). In patients with non-traumatic cerebral hemorrhage, the risk of severe consciousness disturbance increased approximately linearly with increasing TyG index levels when they were in the range of 8.75–9.40 (model 1: P-nonlinear 0.1949; model 2: P-nonlinear 0.2349; model 3: P-nonlinear 0.4873). When the TyG index was higher than 8.75, the risk of patient mortality in the hospital increased approximately linearly (model 1: P-nonlinear 0.9727; model 2: P-nonlinear 0.9051; model 3: P-nonlinear 0.5061) with increasing TyG index (Fig. 2). In patients with cerebral infarction, the risk of severe disturbance of consciousness (model 1: P-nonlinear 0.4879; model 2: P-nonlinear 0.5269; model 3: P-nonlinear 0.4432) and in-hospital death (model 1: P-nonlinear 0.3302; model 2: P-nonlinear 0.2823; model 3: P-nonlinear 0.2378) increased approximately linearly with TyG index levels (Fig. 3). Fig. 2 RCS curve of TyG index and OR in patients with nontraumatic cerebral hemorrhage: (A, B, and C) RCS curve for severe disturbance of consciousness. (D, E, and F) Restricted cubic spline for hospital mortality Fig. 3 RCS curve of TyG index and OR in patients with cerebral infarction: (A, B, and C) RCS curve for severe disturbance of consciousness. (D, E, and F) RCS curve for hospital mortality The predictive ability and incremental effect of the TyG index Furthermore, we calculated the area under the ROC curve (AUC) to examine the TyG index’s ability to predict the severity of patients’ disturbance of consciousness and in-hospital mortality. The results showed that in patients with non-traumatic cerebral hemorrhage, the AUC of the TyG index to predict the severity of impaired consciousness was higher than 0.6 (IQR: 0.627 [0.551, 0.704]; numeric: 0.610 [0.528, 0.692]) (Fig. 4A), and the AUC predicting in-hospital mortality was higher than 0.65 (IQR: 0.664 [0.606, 0,722]; numeric: 0.661 [0.600, 0.721]) (Fig. 4C). The TyG index’s AUC for predicting the severity of consciousness disturbances in patients with cerebral infarction was higher than 0.55. (IQR: 0.579 [0.532, 0,626]; numeric: 0.571 [0.522, 0.620]) The AUC for predicting in-hospital mortality was greater than 0.6 (Fig. 4B) (IQR: 0.608 [0.556. 0.660]; numeric: 0.610 [0.556, 0.663]) (See Fig. 4D). Altogether, The TyG index offers some predictive value for the severity of consciousness disturbances as well as in-hospital mortality in patients with the cerebrovascular disease. Fig. 4 (A and B) ROC curve analysis of TyG index predicting severe disturbance of consciousness in patients with non-traumatic cerebral hemorrhage (A) and cerebral infarction (B); (C and D) ROC curve analysis of TyG index predicting in-hospital mortality in patients with non-traumatic cerebral hemorrhage (C) and cerebral infarction (D) In addition, we calculate the IDI of the scoring tools (APSIII, OASIS, SAPSII) when the TyG index is considered to analyze the impact of the TyG index on the predictive ability to score tools. IDI is a tool for assessment that responds to the degree of improvement in the predictive ability of the model, with a value greater than 0 indicating a positive improvement and a value less than 0 indicating a negative improvement. The results demonstrate that the predictive ability of the scoring tools with the TyG index has improved in comparison to those without the TyG index. After considering the TyG index according to quartile classification (TyG (IQR)), the predictive ability of the scoring tool for severe disturbance of consciousness and mortality was significantly improved (P < 0.05) in both non-traumatic cerebral haemorrhage and cerebral infarction patients. The predictive ability of the scoring tool for mortality was improved significantly (P < 0.05) when the numerical TyG index (TyG (numeric)) was considered for both, whereas the improvement in predictive ability for severe consciousness impairment was not statistically significant (P > 0.05) (Table 4). Moreover, we drew clinical decision curves to assess the clinical utility improvement of the TyG index. The results showed that the net clinical benefit of each scoring tool also had an improvement after considering the TyG index (Fig. 5). Table 4 The incremental effect of the TyG index Score AUC [95% CI] IDI [95% CI] (+ TyG (IQR)) P-value IDI [95% CI] (+ TyG (numeric)) P-value Severity of consciousness disturbance (patients with non-traumatic cerebral hemorrhage) APSIII 0.672 [0.594, 0.750] 0.0148 [0.0052, 0.0244] 0.0025 0.0016 [-0.0018, 0.0050] 0.3554 OASIS 0.641 [0.562, 0.719] 0.0162 [0.0054, 0.0271] 0.0034 0.0028 [-0.0017, 0.0073] 0.2262 SAPSII 0.654 [0.574, 0.733] 0.0156 [0.0048, 0.0264] 0.0047 0.0023 [-0.0021, 0.0067] 0.3099 In-hospital mortality (patients with non-traumatic cerebral hemorrhage) APSIII 0.736 [0.680, 0.793] 0.0385 [0.0188, 0.0581] 0.0001 0.0303 [0.0104, 0.0502] 0.0029 OASIS 0.746 [0.695, 0.797] 0.0560 [0.0329, 0.0791] < 0.0001 0.0415 [0.0191, 0.0640] 0.0003 SAPSII 0.757 [0.704, 0.810] 0.0520 [0.0298, 0.0741] < 0.0001 0.0449 [0.0217, 0.0681] 0.0002 Severity of consciousness disturbance (patients with cerebral infarction) APSIII 0.664 [0.584, 0.744] 0.0164 [0.0060, 0.0267] 0.0020 0.0018 [-0.0017, 0.0053] 0.3166 OASIS 0.625 [0.542, 0.708] 0.0176 [0.0057, 0.0294] 0.0037 0.0027 [-0.0019, 0.0074] 0.2452 SAPSII 0.643 [0.560, 0.726] 0.0164 [0.0044, 0.0283] 0.0072 0.0021 [-0.0023, 0.0064] 0.3508 In-hospital mortality (patients with cerebral infarction) APSIII 0.741 [0.683, 0.799] 0.0414 [0.0202, 0.0626] 0.0001 0.0367 [0.0138, 0.0597] 0.0017 OASIS 0.753 [0.700, 0.806] 0.0598 [0.0349, 0.0847] < 0.0001 0.0489 [0.0236, 0.0742] 0.0002 SAPSII 0.750 [0.694, 0.806] 0.0567 [0.0325, 0.0809] < 0.0001 0.0508 [0.0251, 0.0765] 0.0001 Fig. 5 Decision curve analysis of scoring tools with and without considering the TyG index (IQR). (A) Predicting severe disturbance of consciousness in patients with non-traumatic cerebral hemorrhage. (B) Predicting in-hospital mortality in patients with non-traumatic cerebral hemorrhage. (C) Predicting severe disturbance of consciousness in patients with cerebral infarction. (D) Predicting in-hospital mortality in patients with cerebral infarction Discussion This study reveals for the first time that the TyG index can predict severe disturbance of consciousness in patients with critical cerebrovascular disease, and we also investigate the impact of the TyG index on the prognosis of these patients. The study demonstrates that in critically sick patients with cerebrovascular illness, high levels of the TyG index are a significant independent risk factor for the severity of consciousness disturbance and in-hospital mortality. Even after potential confounders were considered, this association still held true. Our findings also indicated that the degree of patients’ consciousness disturbance and in-hospital mortality were linearly related to the TyG index. Cerebrovascular disease remains the main cause of mortality and disability worldwide, despite notable improvements in early diagnosis and treatment [19]. Type 2 diabetes is an established risk factor for cerebrovascular disease [20, 21]and is associated with the high risk of both ischemic and hemorrhagic strokes [22]. In type 2 diabetic patients, hyperglycemia is also linked to an increased risk of cerebrovascular diseases [22]. Currently available anti-diabetic drugs mainly play a role through two main mechanisms: insulin resistance (IR) and pancreatic β-cell dysfunction [23]. According to the evidence, IR, beta-cell dysfunction, and hyperglycemia affect the risk of cardiovascular disease independently of each other [24]. IR is not only a risk factor for the development of cardiovascular disease but is also associated with the prognosis of cardiovascular disease [25]. Whether or not they result in clinically significant vascular events, cardiovascular risk factors are linked to pathological brain damage associated with cognitive dysfunction [26, 27]. In addition, several pathophysiological processes suggest that hyperviscosity and increased nitrogenous waste due to metabolic disturbances may be potential mechanisms for IR to exacerbate disturbance consciousness in cerebrovascular disease patients. Nevertheless, there are no studies to verify this [13–17]. The TyG index is considered a credible and straightforward surrogate marker of IR for clinical practice [28]. A study of 6,091 patients showed that the TyG index had a higher predictive ability for metabolic syndrome than HOMA-IR (homeostatic model assessment to determine insulin resistance) (0.837 vs. 0.680, P-value < 0.001) [29]. In parallel, the fasting triglyceride and glucose data required to calculate the TyG index are easily accessible clinically, making the application of the TyG index simpler as well. However, the TyG index is affected by variables such as race and alcohol consumption. We therefore accounted for these confounding variables in the model’s adjustment. The results of this study showed that the TyG index was predictive of the severity of consciousness disturbance and prognosis in both non-traumatic cerebral hemorrhage and cerebral infarction patients. There are currently very few studies on the impact of the TyG index on cerebrovascular patients’ in-hospital mortality and consciousness disturbance. An earlier long-term follow-up investigation revealed that a high TyG index level was a strong independent predictor of cerebrovascular events [30]. Several potential mechanisms have been suggested to explain the correlation between the TyG index and the development of cerebrovascular diseases. First, IR activates inflammation-related genes and interferes with insulin signaling [31, 32], leading to varying degrees of chronic inflammation, oxidative responses, and endothelial cell dysfunction to damage blood vessels [33, 34], leading to cerebrovascular disease. Secondly, in the IR state, the production of endothelial nitric oxide and the release of procoagulant factors lead to platelet aggregation and induce a prothrombotic state [35], which leads to disorders in the coagulation of the body and triggers cerebrovascular lesions accordingly [36, 37]. Lastly, IR induces prolonged endoplasmic reticulum stress and macrophage apoptosis, increases late vulnerable plaque formation, and causes plaque necrosis at the onset of atherosclerosis [32, 38]. Moreover, IR exacerbates the effects of other vascular risk factors, and leads to the development of cerebrovascular disease [9]. The progression of cerebrovascular disease then directly affects the severity of the patient’s consciousness disturbance and prognosis. In summary, this study revealed the significant effect of the TyG index on the severity of consciousness disturbance and prognosis of patients with cerebrovascular disease. However, there are some other limitations of the present study that should be mentioned. Firstly, the results were not representative because all enrolled patients were from an American population. Secondly, due to the limitations of public databases, some potential confounders we did not include in the study such as dietary patterns, physical activity, long-term antihypertensive drugs use. Additionally, patients’ personal histories such as tobacco use, alcohol abuse, and long-term anticoagulant use were identified by ICD in this study. However, some patients with these personal histories were not documented by the clinician in the discharge or admission diagnosis. This may prevent us from identifying certain patients with tobacco use, alcohol abuse, or long-term anticoagulant use. Finally, due to the small sample size, the results from this study need to be validated in a larger cohort. Conclusion Our study showed that the TyG index was a significant predictor of severe disturbance of consciousness and prognosis in critically ill patients with cerebrovascular disease, associated with the risk of severe disorder of consciousness and in-hospital mortality in an approximately linear relationship. Moreover, the TyG index offers some predictive value for severe consciousness disturbances as well as in-hospital mortality in patients with cerebrovascular disease, which may increase the accuracy of identifying high-risk patients. List of abbreviations MIMIC-IV Medical Information Mart for Intensive Care IV TyG index Triglyceride-glucose index ICU Intensive care unit ROC Receiver operating characteristic IR Insulin resistance ICD-10 International Classification of Diseases, Tenth Revision ICD-9 Based on the International Classification of Diseases, Ninth Revision GCS Glasgow coma scale SQL Structured query language BMI Body mass index CPK Creatine phosphokinase CKMB Creatine kinase isoenzyme MB IDH Lactate dehydrogenase ALP Alkaline phosphatase AST Aspartate aminotransferase INR International normalized ratio ALT Alanine aminotransferase PT Prothrombin Time PTT Active partial thromboplastin time CKD Chronic kidney disease SD Standard deviation IQR Interquartile range ORs Odds ratios CI Confidence intervals HbA 1c Glycated hemoglobin A 1c APSIII Acute physiology score III OASIS Oxford acute severity of illness score SAPSII Simplified acute physiology score Authors’ contributions Ting Chen is responsible for data extraction, data analysis, results visualization, and manuscript writing. Yuan Qian provided professional advice for the revision of the manuscript. Xingli Deng was responsible for the review and revision of the manuscript and the funding of the study. Funding The research was funded by Key Project of Yunnan Province Applied Basic Research Program (202101AY070001-017), The Major Science and Technology Special Project of Yunnan Province (202102AA100061), and Specialized Project for Young Top Talents of Yunnan Province Ten Thousand Talent Plan. Declarations Ethics approval and consent to participate The MIMIC-IV project was approved by the institutional review board of the Massachusetts Institute of Technology and Beth Israel Deaconess Medical Center. The patients’ information was anonymized, and thus the need for patients’ informed consent was waived for this study. Consent for publication Not applicable. Competing interests The authors declare that they have no competing interests. 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