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J Epidemiol Community Health
J Epidemiol Community Health
jech
jech
Journal of Epidemiology and Community Health
0143-005X
1470-2738
BMJ Publishing Group BMA House, Tavistock Square, London, WC1H 9JR

38991761
jech-2022-220163
10.1136/jech-2022-220163
Research Agenda
1506
1507
Intergenerational transmission of health inequalities: research agenda for a life course approach to socioeconomic inequalities in health
http://orcid.org/0000-0001-6090-4376
Houweling Tanja A J 1
http://orcid.org/0000-0002-7034-1922
Grünberger Ilona 2
1 Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
2 Department of Public Health Sciences, Stockholm University, Stockholm, Sweden
Correspondence to Dr Tanja A J Houweling, Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands; a.j.houweling@erasmusmc.nl
10 2024
11 7 2024
78 10 650653
05 12 2022
03 8 2023
© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
2024
https://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

Explanations for socioeconomic inequalities in adult health are usually sought in behaviours and environments in adulthood. Yet, there is compelling evidence that the first two decades of life contribute substantially to both adult socioeconomic position (SEP) and adult health. This has implications for explanatory health inequalities research.

We propose an analytical framework to advance research on the intergenerational transmission of health inequalities, that is, on intergenerational transmission of socioeconomic and associated health (dis)advantages at the family level, and its contribution to health inequalities at the population level. The framework distinguishes three transmission pathways: (1) intergenerational transmission of SEP, with effects on offspring health fully mediated by offspring SEP; (2) intergenerational transmission of health problems affecting SEP and (3) intergenerational transmission of both SEP and health, without a causal relationship between offspring adult SEP and health. We describe areas for future research along this framework and discuss the challenges and opportunities to advance this field.

Health inequalities
Life course epidemiology
CHILD HEALTH
PUBLIC HEALTH
Norwegian Research Council 288638 NWO NWA.1238.18.001 Royal Dutch Academy of Sciences (KNAW) NA Swedish Research Council for Health, Working Life and Welfare FORTE project number 2018-00211 http://dx.doi.org/10.13039/501100001826 ZonMw 531003013 special-featureunlocked
special-featureeditors-choice
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pmcA framework for research

Traditionally, explanations for socioeconomic inequalities in adult health are sought in behaviours and environments in adulthood.1 Figure 1 visualises this relationship between adult socioeconomic position (SEP) and adult health. In this framework, SEP is causally related to proximal health determinants, such as smoking, and health outcomes in adulthood; and there is some reverse causation between health (determinants) and SEP (also called ‘selection’).

Figure 1 Traditional framework for explaining socioeconomic health inequalities. SEP, socioeconomic position.

Yet, from a broad range of disciplines, there is evidence that the early years of life contribute substantially to both adult SEP and adult health. In a companion paper, we have described how socioeconomic and health (dis)advantages are intergenerationally transmitted at the family level, and contribute to the persistence of socioeconomic health inequalities at the population level.2 We found evidence that broadly the same mechanisms, in the fetal and postnatal environment, shape both adult SEP and adult health. This has implications for explanatory research on socioeconomic inequalities in health.

Figure 2 provides a framework for studying socioeconomic health inequalities from an intergenerational perspective. The pathways through which health inequalities are intergenerationally transmitted, can be grouped into three models.

Figure 2 Conceptual framework for the intergenerational transmission of health inequalities. Three models of intergenerational transmission of socioeconomic health inequalities: (1) socioeconomic transmission: intergenerational transmission of SEP, combined with an effect of offspring adult SEP on health; (2) health transmission: intergenerational transmission of parental health problems that affect SEP; (3) sociobiological transmission: parental SEP influences both offspring SEP and offspring health (determinants). SEP, socioeconomic position.

In the first model (socioeconomic transmission, red arrows), the SEP-health link is transmitted across generations as a result of intergenerational transmission of SEP.3 Intergenerational transmission of SEP occurs through (in)direct transfers (eg, of wealth), and via the fetal and postnatal environment—through the influence of parental SEP, parental proximal health determinants and parental health outcomes associated with SEP. As long as offspring adult SEP influences health, there needs to be no direct causal relationship between parental SEP and offspring health (determinants) for health inequalities to be intergenerationally transmitted. In this model, the relationship between parental SEP and offspring health, is fully mediated by offspring SEP. Consequently, statistical adjustment for offspring SEP would lead to severe underestimation of the contribution of intergenerational transmission to adult health inequalities.

In the second model (health transmission, blue arrows), the SEP-health link is transmitted across generations through intergenerational transmission of health problems that affect SEP, such as mental health problems. There is substantial evidence that such parental problems affect child development and well-being, but there is a paucity of evidence about their role in explaining offspring adult health inequalities.

The third model (sociobiological transmission, green arrows) consists of a purely intergenerational causal effect of SEP on adult health. Here, parental SEP influences both offspring SEP and offspring health (determinants), without a causal relationship between offspring adult SEP and health.3 This is sometimes called indirect selection. The fetal environment, the learning and psychosocial environment, and childhood and adolescent socialisation, affect offspring adult SEP and health by influencing child and adolescent cognitive, socialemotional, and physical health and development, and patterns of beliefs, values and behavioural habits.

In practice, SEP and health are causally related within and across generations—their contributions varying with the health outcome studied—such that the three above models reinforce each other. The relative importance of the three models, and how this varies over historical time and across societal contexts, remains largely unknown. Yet, this is crucial information for designing interventions and determining the appropriate timing of policies to reduce health inequalities.4

Research agenda based on the framework

Our framework can be used as basis for asking relevant questions to advance this field, including questions around how policies and other societal conditions affect the different pathways in this framework.

Intergenerational transmission of SEP

A first set of questions relates to the intergenerational transmission of SEP. What proportion of adult health inequalities is attributable to the effect of parental SEP on offspring SEP? A rough calculation can be analogous to that of population attributable fractions. So, with what percentage would health inequalities reduce if offspring of low SEP parents had the same educational (wealth, income) distribution as offspring of high SEP parents? Next, what is the impact of structural determinants of intergenerational social mobility, for example, social protection policies and education systems, on adult health inequalities? Intergenerational social mobility is larger in some cohorts and countries than in others,5 arguably affecting the proportion of health inequalities attributable to intergenerational SEP persistence. This suggests room for policy-making, by ensuring that all children can develop to their full potential, irrespective of parental SEP. It also suggests the need to better understand these structural factors and their political and historical determinants.

The effect of parental and offspring SEP on offspring health

A second set of questions relates to the effect of parental and offspring SEP on offspring health. Does parental SEP have an independent effect on offspring adult health, that is, not mediated by offspring adult SEP?6–8 To what extent is the health effect of offspring adult SEP explained by parental SEP? What is the relative importance of the independent effects of offspring and parental SEP? Three methodological problems complicate answering these questions. The first is intermediate confounding. Important determinants of both offspring SEP and offspring health—including cognitive ability, socialemotional well-being and habits—are strongly influenced by parental SEP. When examining the independent health effects of offspring SEP, these factors, shaped in early life, could be important confounders.9 The second problem is mediator-outcome confounding (collider bias). Independent effects of parental and offspring SEP are mostly examined in discordant parent-offspring pairs, that is, in cases of intergenerational upward or downward mobility.6–8 But these may be selective groups. Analyses should, therefore, be adjusted for factors influencing both intergenerational mobility and offspring adult health. Third, intergenerational social mobility may have health effects itself, requiring the inclusion of interaction terms between parental SEP and offspring adult SEP. Modern causal mediation analyses can partly address these problems and be used to decompose the effect of parental SEP on offspring health into direct effects, and indirect effects via offspring SEP, even in the presence of interaction.10 Also, structured approaches to compare life course models have been applied to these questions.4 11 Howe et al have linked causal mediation analysis to a structured life course approach.3 A next step would be to address intermediate confounding and mediator-outcome confounding in such models.

While the above models and mechanisms could be seen as acting within relatively stable social and policy contexts, another way forward would be through research on the health effects of exogenous changes in parental and offspring adult SEP, for example, income changes due to new social security policies. A possible strategy would be to focus on determinants of adult health that are largely shaped in early life—including cognitive ability, executive functions, social-emotional well-being, habits and beliefs12 13—and examine to which extent these explain adult health inequalities.14 Such a strategy could also include research on (1) stability of the association between SEP on the one hand, and cognitive ability, executive functions, behavioural habits and beliefs on the other, throughout childhood, adolescence and beyond15; (2) their contribution to inequalities in health behaviours in adulthood and (3) and their interaction with the environment in both childhood and adulthood (eg, Are changes in school policies affecting children from disadvantaged backgrounds disproportionately? Is a health promoting environment more important for individuals with lower executive functions?)

Intergenerational transmission of health problems associated with SEP

A third set of questions relate to the intergenerational transmission of health problems that are associated with SEP. What is the contribution of parental health problems, such as mental health problems, which affect both parental SEP and their offspring’s development and life course outcomes, to the intergenerational transmission of health inequalities? And what is the relative importance of fetal and postnatal environmental pathways to this transmission? A first step would be to describe what proportion of parents with low SEP suffer from such health problems. In social epidemiological research, low SEP tends to be treated as a uniform category.16 Unpacking this to understand the complex set of problems underlying low SEP, and how these problems cluster and interact, and are transmitted intergenerationally in different societal and policy contexts, is important, also for policy-making.

Conclusion

The first two decades of life, from the prenatal period to early adulthood, play an important role in the development of socioeconomic inequalities in adult health and help explain the persistence of these inequalities in welfare states. It is time to give more attention to these early years in research on and policies to tackle adult health inequalities. It is important to recognise that SEP, and many determinants of health and health behaviour, are formed early in life. SEP and health determinants that are shaped in these early years—including cognitive development, executive functions, beliefs and habits—should not be taken as a given. Rather, understanding their development and intergenerational transmission should be squarely rooted within health inequalities research, thereby providing a basis for preventive policies.

Methodological advances and the coming of age of many birth cohorts provide opportunities for empirical research across multiple generations. We have provided a framework to advance this research field. It will require interdisciplinary research to not only understand the complexities of the physiological processes that lead to intergenerational transmission of health inequalities, but also the social complexities that often remain hidden behind the term ‘SEP’. Importantly, our framework also describes new opportunities for action. There is a lot to be gained.

We thank Prof. Johan P. Mackenbach for his comments on an outline of this paper and for helpful discussions during preparation of the International Symposium on the Intergenerational Transmission of Health Inequalities that TAJH organised with him on 25 October 2018 –26 October 2018, Rotterdam, the Netherlands. We thank presenters and participants at this symposium for their presentations and their contributions to the discussions.

Ethics statements

Patient consent for publication

Not applicable.

X @TanjaHouweling

Contributors: TAJH conceived of and drafted the manuscript. IG critically reviewed the draft manuscript and contributed to revisions. Both authors have approved of the final manuscript before submission.

Funding: TAJH is supported by NWO grant number NWA.1238.18.001 and though a grant awarded by the Norwegian Research Council (project number 288638) to the Centre for Global Health Inequalities Research (CHAIN) at the Norwegian University for Science and Technology (NTNU). The International Symposium on the Intergenerational Transmission of Health Inequalities was financially supported by the Royal Dutch Academy of Sciences (KNAW) and a EUR Research Excellence initiative grant obtained by TAJH. TAJH is also member of a ZonMW funded project on socioeconomic inequalities in child development (grant number 531003013). IG is supported by a grant from the Swedish Research Council for Health, Working Life and Welfare (FORTE project number 2018-00211).

Disclaimer: The funders had no role in study design; in the collection, analysis and interpretation of data; in the writing of the articles; and in the decision to submit it for publication.

Competing interests: None declared.

Provenance and peer review: Not commissioned; internally peer reviewed.
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