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J Korean Med Sci
J Korean Med Sci
JKMS
Journal of Korean Medical Science
1011-8934
1598-6357
The Korean Academy of Medical Sciences

10.3346/jkms.2024.39.e287
Editorial
In This Issue on 23-September-2024
https://orcid.org/0000-0003-2611-3399
Yoo Jin-Hong Editor-in-Chief, Journal of Korean Medical Science
Division of Infectious Diseases, Department of Internal Medicine, Bucheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Address for Correspondence: Jin-Hong Yoo, MD, PhD. Division of Infectious Diseases, Department of Internal Medicine, Bucheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, 327 Sosa-ro, Wonmi-gu, Bucheon 14647, Republic of Korea. editor.jkms@kams.or.kr
23 9 2024
06 9 2024
39 36 e287© 2024 The Korean Academy of Medical Sciences.
2024
The Korean Academy of Medical Sciences
https://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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pmcIn this issue, 3 original articles have been published.

1. Direct Oral Anticoagulants in Antiphospholipid Syndrome-Associated Venous Thromboembolism: Real World Evidence.

Bang SM, et al.

This study evaluated the efficacy and safety of direct oral anticoagulants (DOACs) versus warfarin in patients with antiphospholipid syndrome-associated venous thromboembolism (APS-VTE) using the Korean Health Insurance Review and Assessment Service database. Among 84,916 VTE cases, 410 were APS-VTE. DOACs showed comparable rates of recurrent VTE, bleeding, and deaths but significantly lower arterial thrombosis (3.8% vs. 10%) and composite outcomes (9.1% vs. 16.3%) compared to warfarin. Most APS-VTE patients (73%) were under 60 years old. The study concluded that DOACs are a viable alternative to warfarin for APS-VTE patients.

2. Diagnostic Utility of Whole Genome Sequencing After Negative Karyotyping/Chromosomal Microarray in Infants Born With Multiple Congenital Anomalies.

Chang YS, et al.

This study evaluated the diagnostic efficacy of whole genome sequencing (WGS) in infants with multiple congenital anomalies (MCAs) in neonatal intensive care units (NICUs) who had negative results from karyotyping and/or chromosomal microarray analysis (CMA). Eighty infants were enrolled, and their phenotypic characteristics were classified. The diagnostic yield of WGS was 26%, with 76% being novel variants. Higher diagnostic yields were observed in craniofacial abnormalities, while lower yields were seen in gastrointestinal and genitourinary abnormalities. WGS-diagnosed infants had higher rates of rehabilitation therapy and gastrostomy. The study concluded that WGS improves diagnostic yield and clinical utility for MCAs in NICUs.

3. Masticatory Function, Sex, and Risk of Dementia Among Older Adults: A Population-Based Cohort Study.

Kim KW, et al.

This study investigated the link between masticatory function and dementia risk in older adults. Data from 5,064 non-demented Koreans aged ≥ 60 years were analyzed over 8 years. Males who chewed ≥ 30 cycles/bite showed faster cognitive decline and higher risk of all-cause dementia (hazard ratio [HR], 2.91) and Alzheimer’s disease (HR, 3.22) compared to those with < 10 cycles/bite. Increased chewing cycles in males were also linked to reduced brain volume. No significant association was found in females. The study suggests older men who chew frequently may be at higher risk for dementia and should be monitored for cognitive decline.

Disclosure: The author has no potential conflicts of interest to disclose.
