
==== Front
Ren Fail
Ren Fail
Renal Failure
0886-022X
1525-6049
Taylor & Francis

10.1080/0886022X.2024.2402505
2402505
Version of Record
Letter to the Editor
Cardio-renal Physiology and Disease Processes
Comment on ‘the clinical evaluation of the triglyceride-glucose index as a risk factor for coronary artery disease and severity of coronary artery stenosis in patients with chronic kidney disease’
Z. Wang and F. Pang
Wang Zhaodong a
Pang Fangfang b
a Anesthesiology Department, Yantai Harbour Hospital, Yantai City, Shandong Province, China
b Department of Geriatrics, Yantai Harbour Hospital, Yantai City, Shandong Province, China
pff0824@163.com
16 9 2024
2024
16 9 2024
46 2 240250526 8 2024
5 9 2024
KnowledgeWorks Global Ltd.13 9 2024
published online in a building issue13 9 2024
© 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
2024
The Author(s)
https://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

The author(s) reported there is no funding associated with the work featured in this article.
==== Body
pmcChronic kidney disease (CKD) is one of the risk factors of coronary artery disease (CAD) [1]. Patients with CKD undergoing coronary angiography are prone to contrast-related acute kidney injury, and even death in severe cases [2]. Therefore, it is important to identify the risk factors for CAD in patients with CKD. Recently, we studied the article ‘The clinical evaluation of the triglyceride-glucose index as a risk factor for coronary artery disease and severity of coronary artery stenosis in patients with chronic kidney disease’ by Liu et al. which provides important ideas for early clinical identification and prevention of CHD in CKD patients. However, three issues remain to be noticed.Multivariate logistics regression analysis was used to evaluate whether triglyceride-glucose index (TyG) is an independent risk factor for coronary heart disease in patients with chronic kidney disease. In addition to TyG, the variable triglycerides were included in the model. Because TyG is calculated from triglycerides and fasting plasma glucose, multicollinearity exists between TyG and triglycerides. When variables with multicollinearity are included in the multivariate logistics regression analysis model, it can lead to model instability, making the reliability of the final conclusions challenging.

CKD patients present with a persistent systemic inflammatory response, which is an important cause of atherosclerosis [3]. We considered that the inclusion of some variables associated with systemic inflammation, such as systemic inflammation index, may enable a more comprehensive assessment of risk factors causing CHD in patients with CKD and could further improve the clinical applicability of this study.

In the comparison of the baseline information, patients were divided into three groups according to the Gensini score. However, when assessing the association between TyG and severity of coronary artery stenosis, patients were divided into two groups. At this point, it is better to propose the reason for combining low and medium Gensini scores into one group.

Disclosure statement

No potential conflict of interest was reported by the author(s).
==== Refs
References

1 Jankowski J, Floege J, Fliser D, et al. Cardiovascular disease in chronic kidney disease: pathophysiological insights and therapeutic options. Circulation. 2021;143 (11 ):1157–1172. doi: 10.1161/CIRCULATIONAHA.120.050686.33720773
2 Liu Y, Tan N, Huo Y, et al. Simplified rapid hydration prevents contrast-associated acute kidney injury among CKD patients undergoing coronary angiography. JACC Cardiovasc Interv. 2023;16 (12 ):1503–1513. doi: 10.1016/j.jcin.2023.03.025.37380233
3 Yan Z, Shao T. Chronic inflammation in chronic kidney disease. Nephron. 2024;148 (3 ):143–151. doi: 10.1159/000534447.37852189
