
==== Front
ArXiv
ArXiv
arxiv
ArXiv
2331-8422
Cornell University

arXiv:2409.02395v2
2409.02395
2
preprint
Article
Deep Brain Ultrasound Ablation Thermal Dose Modeling with in Vivo Experimental Validation
Zhao Zhanyue
Szewczyk Benjamin
Tarasek Matthew
Bales Charles
Wang Yang
Liu Ming
Jiang Yiwei
Bhushan Chitresh
Fiveland Eric
Campwala Zahabiya
Trowbridge Rachel
Johansen Phillip M.
Olmsted Zachary
Ghoshal Goutam
Heffter Tamas
Gandomi Katie
Tavakkolmoghaddam Farid
Nycz Christopher
Jeannotte Erin
Mane Shweta
Nalwalk Julia
Burdette E. Clif
Qian Jiang
Yeo Desmond
Pilitsis Julie
Fischer Gregory S.
5 9 2024
arXiv:2409.02395v24 9 2024
https://creativecommons.org/licenses/by-nc-sa/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License, which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator. If you remix, adapt, or build upon the material, you must license the modified material under identical terms.
http://arxiv.org/abs/2409.02395v2
nihpp-2409.02395v2.pdf
Intracorporeal needle-based therapeutic ultrasound (NBTU) is a minimally invasive option for intervening in malignant brain tumors, commonly used in thermal ablation procedures. This technique is suitable for both primary and metastatic cancers, utilizing a high-frequency alternating electric field (up to 10 MHz) to excite a piezoelectric transducer. The resulting rapid deformation of the transducer produces an acoustic wave that propagates through tissue, leading to localized high-temperature heating at the target tumor site and inducing rapid cell death. To optimize the design of NBTU transducers for thermal dose delivery during treatment, numerical modeling of the acoustic pressure field generated by the deforming piezoelectric transducer is frequently employed. The bioheat transfer process generated by the input pressure field is used to track the thermal propagation of the applicator over time. Magnetic resonance thermal imaging (MRTI) can be used to experimentally validate these models. Validation results using MRTI demonstrated the feasibility of this model, showing a consistent thermal propagation pattern. However, a thermal damage isodose map is more advantageous for evaluating therapeutic efficacy. To achieve a more accurate simulation based on the actual brain tissue environment, a new finite element method (FEM) simulation with enhanced damage evaluation capabilities was conducted. The results showed that the highest temperature and ablated volume differed between experimental and simulation results by 2.1884{\deg}C (3.71%) and 0.0631 cm$^3$ (5.74%), respectively. The lowest Pearson correlation coefficient (PCC) for peak temperature was 0.7117, and the lowest Dice coefficient for the ablated area was 0.7021, indicating a good agreement in accuracy between simulation and experiment.

9 pages, 9 figures, 7 tables
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pmc
