
==== Front
eBioMedicine
EBioMedicine
eBioMedicine
2352-3964
Elsevier

S2352-3964(24)00326-8
10.1016/j.ebiom.2024.105290
105290
Corrigendum
Corrigendum to “STING-mediated intestinal barrier dysfunction contributes to lethal sepsis” [EBioMedicine 41 (2019) 497–508]
Hu Qiongyuan ab
Ren Huajian a
Li Guanwei e
Wang Dingyu bc
Zhou Quan b
Wu Jie ab
Zheng Jiashuo ab
Huang Jinjian a
Slade Dominic A. dom.slade@talktalk.net
bd∗
Wu Xiuwen lygwxw@163.com
a∗∗
Ren Jianan JiananR@gmail.com
a∗∗∗
a Research Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China
b Medical School of Nanjing University, Nanjing, China
c State Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animal for Disease Study, Collaborative Innovation Center of Genetics and Development, Model Animal Research Center, Nanjing, China
d Department of Surgery, Salford Royal NHS Foundation Trust, Stott Lane, Salford, United Kingdom
e Department of Colorectal and Anal Surgery, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong, China
∗ Corresponding author. Medical School of Nanjing University, Nanjing, China. dom.slade@talktalk.net
∗∗ Corresponding author. lygwxw@163.com
∗∗∗ Corresponding author. JiananR@gmail.com
21 8 2024
9 2024
21 8 2024
107 105290© 2024 The Author(s)
2024
https://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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pmcThe authors have recently noticed that the published version of this article contained overlapped images in the representative pictures of Figs. 3, Fig. 5, Fig. 7. It was observed that similar images of intestinal and lung hematoxylin and eosin (HE) staining were present in the same experimental groups across different figures (Fig. 3, Fig. 5, Fig. 7). Furthermore, we noticed that there were overlapped images in Fig. 3, Fig. 5 and Supplementary Fig. 6B. The images of kidney (HE staining), intestine (fluorescence staining), and GAPDH share common areas, respectively. These unintentional mistakes happened during figure assembly. Upon reviewing the original raw data and experimental records, corrected versions of Fig. 3, Fig. 5, Fig. 7 are presented below.Fig. 3 STING-KO mice are protected from severe CLP-induced polymicrobial sepsis. (A) Levels of serum I-FABP, ALT, Creatinine, and LDH. (B, C) Representative images of histology (H&E staining) and injury scores for lung, liver and kidney. (D) The Kaplan–Meier survival analysis 120 h after CLP in WT and STING-KO mice. The Kaplan–Meier survival curves were compared by the log-rank test. Line-graphs show mean and standard error. ALT, alanine transaminase; LDH, lactic dehydrogenase. Data are expressed as the mean ± SD. ⁎P < .05 vs sham group; #P < .05 vs CLP group. n = 6 mice per group.

Fig. 5 Treatment with STING agonist worsens polymicrobial sepsis. (A, B) Survival analysis and serum inflammatory cytokines after i.p. injection of 10 mg/kg DMXAA following CLP. (C) Intestinal TNF-α and MPO activity in CLP group after DMXAA treatment. (D) Activation of STING signaling pathway by i.p. injection of DMXAA following CLP. (E) Representative lung and gut H&E images. (F) Intestinal apoptosis by TUNEL analysis. (G, H) ZO-1 and occludin in intestinal sections were analyzed by immunofluorescence and Western blot. MPO, Myeloperoxidase. Data are expressed as the mean ± SD. ⁎P < .05 vs CLP group. n = 6 mice per group.

Fig. 7 DNase I protects against CLP-induced intestinal injury by decreasing mtDNA levels. Mice were subjected to CLP surgery and administrated either DNase or saline 5 h post-operatively. Blood was collected 12 h and 24 h in CLP-induced sepsis mice and (A) levels of serum mtDNA and TNF-α were quantified. (B) Representative intestinal H&E staining, and histology scores. (C) Bacterial CFU was quantified in MLN and blood. mtDNA, mitochondrial DNA. Data are expressed as the mean ± SD. ⁎P < .05, ⁎⁎P < .01; ⁎⁎⁎P < .001. n = 6 mice per group.

These corrections do not change the description, interpretation, or the original conclusions of the manuscript. The authors sincerely apologize for any inconvenience caused by these mistakes.
