
==== Front
Acta Radiol Open
Acta Radiol Open
sparr
ARR
Acta Radiologica Open
2058-4601
SAGE Publications Sage UK: London, England

10.1177_20584601241283780
10.1177/20584601241283780
Case Report
Invasive trigeminal ganglioneuroma: A case report and review of the literature
https://orcid.org/0000-0002-1850-6136
Narra Rama Krishna
Are Kavya
Nuzhat Parveen
Department of Radio diagnosis, 77040 Katuri Medical College , Guntur, India
Rama Krishna Narra, Department of Radio diagnosis, Katuri Medical College, Guntur 522019, India. Email: narra.ramki29@gmail.com
9 2024
9 9 2024
13 9 2058460124128378018 3 2024
30 8 2024
© The Author(s) 2024
2024
The Foundation Acta Radiologica
https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

Ganglioneuromas are rare tumors arising from retroperitoneal and posterior mediastinal sympathetic nerves. Intracranial trigeminal nerve ganglioneuromas are even more rare, with only seven cases reported to date. We present a case of a 65-year-old male with a right-sided throbbing headache type and blindness in his right eye. Magnetic resonance imaging revealed an ill-defined mass lesion in the middle-cranial fossa, with a few areas having a reduced apparent diffusion coefficient and multiple microhemorrhages. Piecemeal debulking of the tumor was achieved by performing a right-middle craniotomy via the pterionic and sub-temporal approach. The detected histological features matched those of a ganglioneuroma (maturing type) of the trigeminal nerve.

trigeminal ganglioneuroma
trigeminal nerve
computed tomography
magnetic resonance imaging
magnetic resonance angiogram
susceptibility-weighted imaging
typesetterts10
==== Body
pmcIntroduction

Ganglioneuromas (GNs) are rare benign tumors originating from neural crest cells, typically from sympathetic nerves of the peripheral nervous system and adrenal glands. The occurrence of GNs within the intracranial region is rare, with only seven documented cases of GNs arising from the trigeminal nerve to date.

Case history

A 65-year-old male was admitted to the Neurology Department of our institution with the symptoms of a right-sided throbbing headache type, progressive diminution of vision in his right eye, tinnitus, hearing loss in his right ear, and swaying to the right side while walking that had been experienced for 3 years. On examination, the patient was afebrile, and his vital signs were within normal limits. On neurological examination, diminished sensation on the right half of his face and complete blindness in his right eye, and conductive hearing loss in right ear (Rinne’s test negative) were observed. All other functions were within normal ranges.

Computed tomography (CT) scans demonstrated a lobulated heterogeneous, predominantly hypodense mass in the right Meckel’s cave and middle-cranial and pterygomaxillary fossa. The lesion extended into the right sphenoid sinus and suprasellar cistern. Erosion and destruction of the adjacent bones including the clivus, sella turcica, and sphenoid and petrous parts of the temporal bone were noted (Figure 1(a)–(c)).Figure 1. (a)–(c) Images of the brain of a 65-year-old male with a trigeminal ganglioneuroma. Axial CT sections of brain in parenchymal and bone windows (a), (b) and sagittal section in the same (c) demonstrating a hypodense lesion in the middle-cranial fossa resulting in erosion of the right petrous temporal bone (white arrow) and Sella turcica and upper part of the clivus (black arrow).

Magnetic resonance imaging (MRI) showed an ill-defined heterogeneous lobulated mass in the middle-cranial fossa and in the base of the skull where the mass was spreading anteriorly into the anterior cranial fossa and the ethmoid sinuses, medially into the sphenoid sinus and suprasellar cistern, and inferiorly into the pterygomaxillary region. On T2-weighted (T2W) images the lesion was heterogenous, and predominantly hyperintense, and hypointense on T1-weighted (T1W) images and on contrast, heterogeneous avid enhancement was noted. Multiple areas showed micro hemorrhaging on susceptibility-weighted imaging (SWI) (Figure 2 (a)–(f)). Balanced fast-field echo revealed a small tail of the lesion extending into the cerebellopontine angle cistern, and the trigeminal nerve was visualized. On magnetic resonance angiography (MRA), the encasement and medial displacement of the right internal carotid artery was noted. On diffusion-weighted imaging (DWI) scans, only a few areas of hyperintensity were observed, with the corresponding regions exhibiting a decreased apparent diffusion coefficient (ADC) (Figure 3(a)–(c)). Based on clinical and imaging findings, a differential diagnosis of Meckel’s cave tumor invasive trigeminal schwannoma and trigeminal ganglioneuroma was considered.Figure 2. (a)–(f): Axial magnetic resonance imaging (MRI) T2W images (a)–(c), T1W images of the brain with (a) and without (b) intravenous contrast, and SWI images of the brain demonstrating heterogeneous, predominantly cystic, lobulated hyperintense mass in the right Meckel’s cave and middle-cranial fossa (white arrows) causing encasement of the right internal carotid artery (black arrow in a), compression of the right-optic nerve (black arrow in b), and extension into the right-middle ear cavity (black arrow in c). On contrast heterogenous enhancement noted (d), (e), with areas of tiny susceptibility effects (white arrows in f) suggestive of microhemorrhages.

Figure 3. (a)–(c): Axial balanced fast-field echo images (a), MRA maximum-intensity projection (b) and ADC (c) images of the brain demonstrating a heterogeneous mass in the right-middle-cranial fossa with a small tail of the lesion from the right trigeminal nerve in the cerebellopontine angle cistern (white arrow) in image (a) and unaffected left trigeminal nerve (black arrow), encasement of the internal carotid artery (ICA) by the mass (white arrows in b) and areas of reduced ADC (c) suggestive of restricted diffusion within the mass.

As the tumor was extensive, a right-pterionic craniotomy was planned with burr holes in the right temporal and parietal bones and debulking of the tumor was performed. A soft to firm encapsulated tumor was noted just beneath the temporal lobe, a cruciate incision was made over the tumor capsule, and central debulking was performed. Tumor was noted encasing the right internal carotid artery, with the tail of the tumor extending along the trigeminal nerve which was separated to the maximum extent and debulking with piecemeal extraction of the tumor was performed. Immediate postoperative period was uneventful, and the patient was stable. The specimens were sent for histopathological examination, which demonstrated intersecting neural cells in fascicles and mature ganglion cells with schwanion stromal background. The specimen was strongly positive for synaptophysin and schwanion background and confirmed the diagnosis of ganglioneuroma (maturing type) of the trigeminal nerve (Figure 4(a)–(d)). Unfortunately, the patient expired on the 10th postoperative day due to an unexpected sudden myocardial infarction.Figure 4. (a)–(d): Hematoxylin and eosin-staining images (a), (b) of the operative specimen reflecting intersecting fascicles (white arrow in a) and mature ganglion cells (white arrow in b). Immunocytochemistry examination with synaptophysin (c) and S100 (d) showing strong positivity.

Discussion

Ganglioneuromas are benign, well-encapsulated, and differentiated tumors composed of ganglion cells of the peripheral nervous system. These tumors commonly derive from sympathetic autonomic ganglia and are generally located in the posterior mediastinum and retroperitoneum, but they also involve adrenal crest cells. 1 An intracranial origin of ganglioneuromas is relatively rare, with only a few cases reported in the literature. These rare tumors typically arise from the trigeminal nerve and are detected in Meckel’s cave and the middle-cranial fossa, cerebellopontine angle, middle ear, and the internal auditory canal. 2

On CT scans, trigeminal ganglioneuromas usually manifest as well-defined hypodense lesions with an HU of +10. Contrast agents may show mild to moderate enhancement depending on the tumor composition. Benign invasive large ganglioneuromas may provoke the mass effect and cause destruction of adjacent bones, including the sphenoid and petrous part of temporal bones, as noted in the present study. On MRI, the tumor is mainly characterized by hypointensity on T1W images and heterogeneous hyperintensity on T2W and FLAIR. On contrast-enhanced images, intensive homo- or heterogeneity is noted. DWI shows a variable appearance, with reduced or elevated ADC values depending on the tumor composition and cellularity. A tail of the tumor may be noted on balanced field echo images, extending toward the course of the trigeminal nerve. Multiple areas of discrete microhemorrhages may be noted on GRE and SWI images. On magnetic resonance spectroscopy, this type of lesion may show a mild decrease in the N-acetyl-aspartate peak and an increase in the choline peak. Differentiation of trigeminal schwannoma from ganglioneuroma is difficult by imaging alone; however, ganglioneuromas may show multiple microhemorrhages on SWI and may show increase blood flow on perfusion MRI. Other imaging differentials to be considered are shown in Table 1.Table 1. Differential diagnosis of invasive trigeminal ganglioneuroma.

Differential diagnosis of invasive trigeminal ganglioneuroma	
1. Chordoma	• Usually midline in position	
• Hyperintense on T2W images	
• Lower ADC compared to trigeminal ganglioneuroma	
2. Chondrosarcoma	• Diffuse chondroid calcifications in rings and arcs	
3. Invasive fungal aspergilloma	• Hyperdense on computed tomography	
• Hypointense on T2W images on MRI with invasion into cavernous sinus and ICA	
4. Cavernous sinus hemangioma	• Bony destruction is rare	
• Hyperintense on T2W MRI	
5. Nasopharyngeal carcinoma	• Epicenter of the mass in the nasopharynx	
• Intracranial extension of the lesion is through perineural spread and direct extension is relatively rare	
6. Metastasis	• More destructive	
• Often multiple with primary identified	

Histopathologically, ganglioneuromas can be single or in groups of mature, giant ganglion cells with the stromal characteristics of a schwannoma, but notably lacking other elements, such as neuroblasts, intermediate cells, or mitotic figures that suggest a benign neoplasm. Invasive ganglioneuromas of the trigeminal nerve are rare, with very few cases reported in the literature (Table 2).Table 2. Review of the literature describing the previous reported case reports.

Case report	Age (years)/sex	Complaints	Location	Imaging findings	Other findings	
Abe et al 3 (1999)	8/Female	Seizures	Left cerebellopontine angle	Hypointense on T1WI, hyperintense on T2WI, and heterogeneous enhancement on postcontrast images	Immunohistochemical finding: S-100 protein positive	
Nakaguchi et al 4 (2012)	55/Male	Headache	Left-middle-cranial fossa	Heterogeneous contrast-enhanced mass	Immunohistochemical finding: S-100 protein positive	
SeulKee Kim et al 5 (2013)	44/Female	Facial pain and numbness	Left cerebellopontine angle	Isointense on T1WI imaging, heterogeneous predominantly hyperintense signal on T2WI.
No evidence of intertumoral hemorrhage or calcification on GRE postcontrast showed minimal contrast enhancement. Diffusion MRI demonstrated hyperintense areas with corresponding reduced ADC	Immunohistochemical finding: S-100 protein positive	
Xiaojuan Deng et al 6 (2016)	19/Male	Headache and dizziness	Left cerebellopontine angle	Hypointense on T1WI, mixed iso- to hyperintense on T2WI. Moderate enhancement on postcontrast images	MRI showed increased perfusion, elevated rCBV, rCBF, isointense on DWI, high ADC, and whorled appearance. SWI showed a black low signal indicating bleeding/calcifications. MRS showed no increase in choline, lower levels of NAA and cho/Cr, and increased Cho/NAA. Immunohistochemical finding: S-100 protein positive	
Ting wang et al 7 (2017)	49/Male	Dizziness	Right-middle-cranial fossa	Hypointense on T1WI and heterogeneity on T2WI images. TIWI showed no diffusion hyperintense but high ADC	Immunohistochemical finding: S-100 protein positive	
Nadeem Khan et al 8 (2017)	52/Male	Facial pain	Meckel’s cave	Homogeneously enhanced mass in the right Meckel’s cave	Immunohistochemical finding: S-100 protein positive	
Brahim EL Mostarchid et al 9 (2022)	24/Male	Facial pain	Posterior middle-cranial fossa	Hypointense on T1WI, and hyperintense on T2WI with heterogeneous minimal enhancement on contrast MRI	Immunohistochemical finding: S-100 protein positive	

Invasive trigeminal ganglioneuromas are well-localized tumors that may originate in the cerebellopontine angle cistern, Meckel’s cave, or middle-cranial fossa along the course of the trigeminal nerve. These tumors may promote erosion and destruction of bones adjacent to the skull base. Therefore, differentiation of the masses of the skull base and middle-cranial fossa should be considered during imaging examinations.

Acknowledgments

None

ORCID iD

Rama Krishna Narra https://orcid.org/0000-0002-1850-6136

Data availability statement

The datasets generated and/or analyzed during the current study are not publicly available but are available from the corresponding author on reasonable request.*

Author contributions: Conceived and designed the analysis: RKN, data collection: KA, contributed data/analysis tools: PN, performed the analysis: RKN, and wrote the paper: RKN.

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Funding: The author(s) received no financial support for the research, authorship, and/or publication of this article.
==== Refs
References

1 Lonergan GJ Schwab CM Suarez ES , et al. Neuroblastoma, ganglioneuroblastoma, and ganglioneuroma: radiologic-pathologic correlation. Radiographics 2002; 22 : 911–934.12110723
2 Bekelis K Meiklejohn DA Missios S , et al. Ganglioneuroma of the internal auditory canal presenting as a vestibular schwannoma. Skull Base Rep 2011; 1 : 89–94.23984208
3 Abe T Asano T Manabe T , et al. Trigeminal ganglioneuroma. Brain Tumor Pathol 1999; 16 : 49–53.10532424
4 Nakaguchi H Murakami M Matsuno A , et al. Ganglioneuroma originating from the trigeminal nerve in the middle cranial fossa. Case report. Neurol Med -Chir 2012; 52 : 95–98.
5 Kim SK Jeong MY Kang HK , et al. Diffusion-weighted magnetic resonance imaging findings in a patient with trigeminal ganglioneuroma. Korean J Radiol 2013; 14 : 118–121.23323041
6 Deng X Fang J Luo Q , et al. Advanced MRI manifestations of trigeminal ganglioneuroma: a case report and literature review. BMC Cancer 2016; 16 : 694.27576442
7 Wang T Ma L Lou X , et al. Trigeminal ganglioneuroma in the middle-posterior cranial fossa: a case report. Chin Med Sci J 2017; 32 : 123–128.28693694
8 Khan N Michael A Choucair A , et al. Trigeminal ganglioneuroma: a rare case of trigeminal neuralgia caused by cerebellopontine angle tumor. World Neurosurg 2017; 99 : 811.e7.
9 Mostarchid BE Mostarchid ME Mohamed A , et al. Trigeminal ganglioneuroma: a rare case of trigeminal neuralgia caused by Meckel’s cave tumour: a case report and review of the literature. World J Adv Res Rev 2022; 13 : 066–070.
