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Neurooncol Adv
Neurooncol Adv
noa
Neuro-Oncology Advances
2632-2498
Oxford University Press US

10.1093/noajnl/vdae090.105
vdae090.105
Final Category: Radiation Therapy Advances
AcademicSubjects/MED00300
AcademicSubjects/MED00310
RADT-13 STEREOTACTIC RADIOSURGERY FOR BRAIN METASTASES SECONDARY TO PERIPHERAL NEURAL CREST TUMORS: A SINGLE INSTITUTION RETROSPECTIVE EXPERIENCE
Kattaa Ahed Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA

Persad Amit Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA

Park David Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA

Hori Yusuke Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA

Emrich Sara Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA

Ustrzynski Louisa Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA

Tayag Armine Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA

Gu Xuejun Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, USA

Rahimy Elham Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, USA

Pollom Erqi Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, USA

Soltys Scott G Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, USA

Chang Steven D Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA

8 2024
02 8 2024
02 8 2024
6 Suppl 1 2024 SNO/ASCO CNS Metastases Conference i32i32
© The Author(s) 2024. Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology.
2024
https://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

Abstract

BACKGROUND

Intracranial BM of peripheral neural crest tumors (PNCTs) are rare, and portent a poor prognosis. No standard treatment has been established to date, and only a few case reports describe the usage of stereotactic radiosurgery (SRS). This study aims to evaluate the efficacy of SRS for BM from PNCTs. Additionally, a comparison between SRS and other treatment modalities have been conducted.

METHODS

We retrospectively reviewed all patients diagnosed with BM from PNCTs between 2001 and 2024 at our institution. LTC was defined as a reduction/stable in tumor size, with no recurrence or hemorrhage as evidenced by radiological assessment.

RESULTS

Among the 8 patients (15 BM) identified, 3 with 6 BM underwent SRS, and 5 with 9 BM underwent other treatments (radiotherapy, craniotomy, or none). Amongst the patients treated with SRS, the median age was 4.0 years (IQR: 1.8-4.0 years) at diagnosis and 100% were male. The median follow-up was 5.5 months (IQR: 2-7 months). Amongst the patients not treated with SRS, the mean age was 2.5 years (Std. deviation: 1.4 years) at diagnosis and 60% were female. The median follow-up was 28 months (IQR: 1- 85 months). The group treated with SRS had LTC rate of 100% with no complications and a survival rate of 33.3% at one year follow up. LTC rate in the group treated with other modalities was 55.6%, with a survival rate of 60% for a one year follow up. There was no significant difference in LTC and survival between groups (p > 0.05).

CONCLUSION

SRS provides a LTC rate of 100% within one year of follow up for BM from PNCTs. We do suggest that there is similarity of outcomes between SRS and other treatment modalities. SRS may be an alternative to more invasive treatments such as craniotomy or conventional radiation in these patients.
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