
==== Front
medRxiv
MEDRXIV
medRxiv
Cold Spring Harbor Laboratory

10.1101/2024.08.26.24312240
preprint
1
Article
An updated molecular diagnostic for surveillance of tetM in Neisseria gonorrhoeae
Palace Samantha G. http://orcid.org/0000-0002-7849-8078

Reyes Jordan A. http://orcid.org/0009-0003-4983-6378

Neubauer Vickers Eric http://orcid.org/0009-0005-7305-897X

Aatresh Aishani V. http://orcid.org/0000-0002-9774-2435

Shen Wei http://orcid.org/0000-0002-8099-8258

Iqbal Zamin http://orcid.org/0000-0001-8466-7547

Grad Yonatan H. http://orcid.org/0000-0001-5646-1314

28 8 2024
2024.08.26.24312240https://creativecommons.org/licenses/by-nc/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.
http://medrxiv.org/lookup/doi/10.1101/2024.08.26.24312240
nihpp-2024.08.26.24312240.pdf
Abstract

Doxycycline post-exposure prophylaxis (doxy-PEP) for sexually transmitted bacterial infections reduces the risk of syphilis and chlamydia, but effectiveness against gonorrhea is variable, likely attributable to varying resistance rates. As doxy-PEP is incorporated into clinical practice, an urgent unanswered question is whether increased doxycycline use will drive tetracycline-class resistance in Neisseria gonorrhoeae . Here, we report an updated RT-PCR molecular diagnostic to detect the tetM gene that confers high-level tetracycline resistance in N. gonorrhoeae .
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pmc
