
==== Front
Heliyon
Heliyon
Heliyon
2405-8440
Elsevier

S2405-8440(24)12378-X
10.1016/j.heliyon.2024.e36347
e36347
Review Article
Food safety issues associated with sesame seed value chains: Current status and future perspectives
Anyogu Amarachukwu amara.anyogu@uwl.ac.uk
a1⁎
Somorin Yinka M. bc1
Oladipo Abigail Oluseye a
Raheem Saki d
a Food Safety and Security, School of Biomedical Sciences, University of West London, London, W5 5RF, United Kingdom
b University of Glasgow, Glasgow, G12 8QQ, United Kingdom
c Department of Biological Science, Ajayi Crowther University, Oyo, Nigeria
d School of Life Sciences, University of Westminster, London, W1W 6UW, United Kingdom
⁎ Corresponding author. amara.anyogu@uwl.ac.uk
1 These two authors contributed equally to this work.

14 8 2024
30 8 2024
14 8 2024
10 16 e3634725 8 2023
13 8 2024
14 8 2024
© 2024 The Authors
2024
https://creativecommons.org/licenses/by-nc/4.0/ This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
Sesame (Sesamum indicum) is an oilseed crop which is increasingly recognised as a functional food by consumers due to its nutritional and nutraceutical components. Consequently, global demand for sesame has increased significantly over the last three decades. Sesame is an important export crop in producing countries, contributing to their socio-economic development. However, in recent years, major foodborne incidents have been associated with imported sesame seeds and products made with these seeds. Foodborne hazards are a potential risk to consumer health and hinder international trade due to border rejections and increased import controls. An insight into the routes of contamination of these hazards across the value chain and factors affecting persistence may lead to more focused intervention and prevention strategies. It was observed that Salmonella is a significant microbial hazard in imported sesame seeds and has been associated with several global outbreaks. Sesame is mainly cultivated in the tropical and subtropical regions of Africa and Asia by smallholder farmers. Agricultural and manufacturing practices during harvesting, storage, and processing before export may allow for the contamination of sesame seeds with Salmonella. However, only a few studies collect data on the microbiological quality of sesame across the value chain in producing countries. In addition, the presence of mycotoxins and pesticides above regulatory limits in sesame seeds is a growing concern. Eliminating foodborne hazards in the sesame value chain requires urgent attention from researchers, producers, processors, and regulators and suggestions for improving the safety of these foods are discussed.

Graphical abstract

Image 1

Highlights

• Foodborne hazards are a major barrier to the global trade of sesame seeds.

• Salmonella and mycotoxins are major hazards in imported sesame seeds.

• Pesticide contamination of sesame is an emerging concern.

• Limited knowledge of hazards in sesame seeds for domestic consumption.

• The safety of sesame along the value chain is an urgent research priority.

Keywords

Food safety
Mycotoxins
Pesticides
Salmonella
Sesamum indicum
Value chain
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pmc1 Introduction

Sesame (Sesamum indicum) is an ancient oilseed crop mainly cultivated for its edible seeds from which oil is produced [1]. Sesame seeds comprise up to 60 % oil, the highest content of all major oilseed crops [2,3]. Sesame is a functional food as it is a source of nutritional and nutraceutical components. Sesame oil is a rich source of polyunsaturated fatty acids (PUFA), such as oleic and linolenic acids [4,5]. Sesame is also an excellent source of proteins, carbohydrates, vitamins, and minerals, including phosphorus, manganese, copper, and iron [6]. Recent studies have reported that sesame is an important natural food source of phytosterols (3–8 mg/g), melatonin (0.04–298.62 ng/g) and tocopherols (530–1000 mg/kg) [[7], [8], [9]]. In addition, lignans such as sesamin, sesamol, sesamolin, and sesaminol are another major group of bioactive compounds found in sesame [9]. These components are associated with various biological and pharmacological activities, including antioxidant, anti-inflammatory, cardioprotective, anticancer and anti-neurodegenerative effects [10].

Consequently, sesame has diverse uses across the food, cosmetic and pharmaceutic industries, and increased demand is driving the growth of the sesame market. The mainstreaming of indigenous foods and ingredients such as hummus, tahini, and halva, particularly in Western diets, have contributed to the increasing demand for sesame seeds [11]. Sesame oil has pleasant sensorial characteristics, and the presence of antioxidants confers increased resistance to rancidity compared to other oils [4,6]. In addition, different applications of sesame include soap and cosmetic production and as a delivery vehicle for fat-soluble drugs [12,13].

The top producers of sesame are in Africa and Asia, where sesame significantly contributes to the local economy through job creation and foreign exchange revenue [1,14]. However, microbial and chemical hazards in this commodity constitute a significant barrier to the global trade of sesame seeds [15,16]. Salmonella spp. and mycotoxin contamination are frequently reported in sesame and sesame-based products. Salmonella spp. and mycotoxins were the most significant hazards in the “nuts, nut products and seeds” category in foods exported into the European Union (EU) in 2018 and 2019 [17]. Recent reports have also highlighted the scale of Salmonella contamination in sesame imported into the EU [16,18]. In addition, outbreaks of salmonellosis associated with sesame and sesame-related products have been reported worldwide [[19], [20], [21]]. Sesame seeds contaminated with mycotoxins have been observed at different stages of the value chain, suggesting this is a widespread problem [22,23]. Pesticides are also an emerging concern. In September 2020, sesame seeds contaminated with ethylene oxide were reported to the EU's Rapid Alert System for Food and Feed (RASFF). This major incident led to several recalls and withdrawals of sesame-containing foods across Europe [24]. Sesame seeds often serve as ingredients in a wide variety of products. Therefore, the presence of hazards in sesame can have severe and widespread health and economic consequences.

Sesame can be exposed to various contaminants at all stages of the value chain. Poor agricultural practices during cultivation, harvesting and storage can allow for microbial and chemical contamination of sesame seeds [25]. Furthermore, the warm and humid conditions characteristic of tropical and subtropical regions where sesame is grown may also create an optimal environment for the growth of foodborne pathogens or the production of microbial toxins, further exacerbating the problem [22].

Several reviews discussing sesame have been published. However, these mainly focus on single aspects such as nutritional or nutraceutical components [4,9,26] or economic value [1,27] to producing countries. Olaimat et al. [28] reviewed the microbial safety of oil-based food products but focused on foodborne pathogens. However, no comprehensive overview of microbial and chemical contamination is focused explicitly on sesame and sesame-based products. Therefore, this review is necessary to summarise current knowledge on the safety of sesame-based foods. It also highlights data gaps for future research and suggests interventions to strengthen the sesame value chain.

2 The global sesame seed market and value chain

Sesame is a highly valued crop worldwide because of its various uses for its seeds and oil in the food, nutraceutical, and pharmaceutical industries. Increased consumer awareness of sesame's health benefits, changing consumption patterns, and a growing population have increased the demand for sesame [27].

The sesame market is projected to grow at a compound annual growth rate of 2.6 % to USD 8.7 billion by 2029 [29]. Global sesame seed production exceeded 7 million tonnes in 2022, an increase of almost 200 % over the last three decades (Fig. 1). Africa and Asia produce over 95 % of the world's supply of sesame. In 2022, the highest producing countries were Sudan, India, Myanmar, the United Republic of Tanzania, and China, accounting for over 60 % of global production (Table 1).Fig. 1 Global production of sesame seed between 1992 and 2022. Source: Food and Agriculture Organisation Statistical Databases [30].

Fig. 1

Table 1 Major producing countries of sesame seeds.

Table 1S/N	Country	Production Quantity (tonnes)	Exports (tonnes)	Export to production ratio (%)	Export value (USD million)	
1	Sudan	1,231,701	356,643	29	509	
2	India	788,740	234,458	30	422	
3	Myanmar	760,926	101,565	13	144	
4	United Republic of Tanzania	700,000	120,987	17	144	
5	China	872,795	90,208	10	202	
6	Nigeria	450,000	297,022	66	331	
7	Burkina Faso	208,796	58,858	28	68	
8	Chad	201,913	69,749	35	102	
9	Central African Republic	190,917	115	0.06	0.01	
10	Ethiopia	180,000	107,719	60	183	
ND - No data available.

Source: Food and Agriculture Organisation Statistical Databases. Data for 2022 [30].

In producing countries, sesame is gaining recognition as a high-value export crop. Over 2.0 million tonnes of unprocessed sesame seeds, valued at USD 3 billion, were traded globally in 2022 [30]. In Nigeria, almost 70 % of domestic sesame production was exported in 2022 (Table 1), and sesame seeds are the third most valuable export product after cocoa and herbs [31]. In addition, Ethiopia, Chad, and India exported 60 %, 35 %, and 30 % of their cultivated sesame in 2022 (Table 1). Asia and Europe are the primary destinations for sesame seeds (Fig. 2). China, Turkey, and Japan are the largest importers of sesame seeds, accounting for about 56 % (almost 1.2 million tonnes) of global imports, valued at nearly USD 1.9 billion [30]. The European Union (EU) is also a growing market for imported sesame seeds primarily used in the food industry to supplement local production [11]. Consequently, sesame is gaining attention as a priority crop, and increasing production has become the focus of many national and international efforts [1,13,32,33].Fig. 2 Major importers of sesame seeds. Data represent import values (USD million) in 2022. Source: Food and Agriculture Organisation Statistical Databases [30].

Fig. 2

The supply chain connecting sesame producers with consumers is global and complex (Fig. 3). In major producing regions, sesame is grown predominantly by smallholder farmers, with a minor contribution from a few large-scale farmers. Producers sell individually or through cooperative unions to wholesalers, the principal actors in the sesame value chain. Exporters purchase the bulk of the seeds, while smaller amounts are sold to processors and local retailers [31,32,34]. Several constraints to the value chain in many low and middle-income sesame-producing countries include access to high-yielding and well-adapted cultivars, seed supply systems, and credit. In addition, there is limited use of modern agricultural production technologies, post-harvest crop management infrastructure and systems [14,35,36]. Sesame value chains are poorly organised in the world's major producing regions. They are, therefore, more vulnerable to foodborne hazards that may pose health risks to consumers.Fig. 3 The sesame supply chain identifying major agents.

Fig. 3

3 Salmonella and other microbial hazards in sesame seeds and associated products

Sesame seeds and sesame seed products such as tahini (sesame paste) and halva are classified as low water activity (aw) foods (aw < 0.70) that typically have an extended shelf life of several months [28]. Low aw does not support the growth of pathogenic and spoilage bacteria [37]. Therefore, these foods are usually considered microbiologically safe. However, factors influencing pathogen survival in low aw foods are poorly understood and vary among foods [38]. The oil content of sesame-based foods may protect some pathogens from preservative measures such as heat treatment and gamma irradiation during processing [39,40].

There have been several reports of imported sesame-based foods contaminated with pathogenic bacteria, notably Salmonella, with severe consequences, including border rejections, product recalls, and foodborne outbreaks [16,20]. Many of these products are purchased as ready-to-eat (RTE) products without a further inactivation step. Therefore, their safety is of paramount importance.

Salmonella has emerged as a significant hazard in sesame seeds and sesame-based products (Table 2) and is becoming increasingly recognised as a source of outbreaks [41]. A notable example was the 2016–2017 outbreak of salmonellosis, with 47 confirmed cases across five European countries. The causative agent was identified as a novel Salmonella enterica subspecies enterica serotype (11: z41: e,n,z15). A traceback investigation implicated sesame paste produced in Greece and sesame seeds imported from Nigeria as the vehicles of transmission [20]. More recently, the European Food Safety Authority (EFSA) reported an outbreak associated with sesame-containing products (halva and tahini) imported from Syria. In total, 135 confirmed cases from five European countries (Denmark, Germany, Netherlands, Norway, Sweden), Canada and the United States of America were infected with six Salmonella enterica serotypes between January 2019 and October 2021 [42]. Other outbreaks of salmonellosis linked to sesame-based foods have been reported in New Zealand [43], Australia [21,43], the United States of America [19,44], and Canada [45].Table 2 Microbial hazards in sesame seeds and sesame-based products.

Table 2Microorganism	Product(s)	Sample collection point	Country (Country of origin)a	Prevalence (n/N)b	Analytical method	Reference	
Salmonella spp.	Sesame seeds	Retail	Italy (Nigeria)	3/36	Conventional	[46]	
S. Montevideo,	
S. Stanleyville,	
S. Tilene	
Salmonella spp.	Sesame seeds	Retail	Mexico (U)	12/100	Conventional	[47]	
Salmonella spp.	Sesame seeds	Point of export	Burkina Faso	95/359	Conventional	[48]	
Salmonella spp.	Sesame seeds	Point of import	United States of America (U)	20/177	Conventional	[49]	
Salmonella spp.	Sesame seeds	Point of import	United States of America (U)	23/233	Conventional	[50]	
Salmonella Offa, Salmonella Tennesee	Sesame seeds	Retail	Germany (U)	2/16	Conventional	[51]	
Salmonella Typhimurium DT104	Tahini	Retail	Germany (Turkey)	1/12	Conventional	
Salmonella Typhimurium DT104, Salmonella Poona	Halvah	Retail	Germany (Turkey)	8/71	Conventional	
Thermotolerant coliforms	Sesame seeds, Sesame-based snacks	Retail	Burkina Faso	32/75	Conventional	[52]	
Microorganism	Product(s)	Sample collection point	Country (Country of origin)c	Prevalence (n/N)b	Analytical method	Reference	
Salmonella spp.	Sesame seeds	Retail	United Kingdom (U)	13/771	Conventional	[53]	
Escherichia coli				8/771			
Salmonella enterica subspecies enterica serotype (11:z41:e,n,z15)	Sesame spread	Retail, Household	Germany, Luxembourg (Sudan)	ND	Conventional, Whole Genome sequencing	[20]	
Sesame seeds	Processor	Germany (Nigeria)	ND	
Sushi containing sesame	Processor	United Kingdom (U)	ND	
Salmonella	Tahini	Retail	Lebanon	7/42	Conventional	[54]	
Escherichia coli	18/42	
Bacillus cereus	Sesame seeds	Retail	Japan (U)	1/6	MALDI TOF-MS	[55]	
Bacillus spp.	Sesame seeds	Retail	United States of America (India, China, Mexico, Unknown)	6/10	16S rRNA amplicon sequencing	[56]	
ND: Not Documented.

a Brackets indicate the country where samples were collected. Where no brackets are used, the country where samples were collected was the same as the country of origin of the seeds. (U): Undeclared country of origin.

b n/N: n, number of contaminated samples; N, Total number of samples.

c Country where samples were collected. Where no brackets are used, the country where samples were collected was the same as the country of origin of the seeds. (U): Undeclared country of origin.

It is important to note that all these outbreaks have involved imported sesame products or raw materials, highlighting the role of the supply chain in the transmission of this microbial hazard. Salmonella is recognised as a significant hazard in sesame seeds imported from Africa into the EU. Fifty-six percent (56 %) of the notifications in the RASFF database arising from pathogenic organisms in foods imported into the EU between 2009 and 2019 were due to Salmonella-contaminated sesame seeds [16]. Similarly, Salmonella contamination was frequently observed in sesame seeds exported into Europe from the Asia-Pacific region between 2000 and 2020 [18]. Van Doren et al. [49] observed that almost 10 % of 229 shipments of sesame seeds imported into the United States of America within a six-month period were contaminated with Salmonella. Conversely, Zhang et al. [57] did not detect Salmonella in 527 samples of imported sesame seeds collected from retail establishments in the United States of America between 2013 and 2014. In addition, Compaore et al. [48] noted that 27 % of 359 sesame samples intended for export from Burkina Faso over a 10-year period were contaminated with Salmonella.

Consequently, RTE sesame seeds and associated products are regarded as high-risk foods and have been subjected to increased official controls in several countries at various times [58,59]. These findings have significant implications for producers, particularly in low- and middle-income countries, where sesame is an essential source of foreign revenue and jobs contributing to socioeconomic development [34].

The prevalence of pathogenic and indicator bacteria in retailed sesame seeds and products made from sesame has also been investigated. Willis et al. [53] studied the prevalence of Salmonella and Escherichia coli in 771 sesame seed samples collected from retail outlets in the United Kingdom. They reported 1.7 % and 1 % prevalence rates for Salmonella and E. coli, respectively. Juarez-Arana et al. [47] also observed that 12 % of sesame seeds sold in Mexican markets were contaminated with Salmonella. Alaouie et al. [54] also reported the presence of Salmonella and E. coli in 47 % and 43 % respectively, of tahini samples collected in Lebanese markets.

Contamination with enteric pathogens such as Salmonella is an indication of unhygienic practices during food production and storage. Sesame seeds are susceptible to microbial hazards from contaminated soil, irrigation water, livestock, equipment surfaces and human handling [25,60]. Salmonella can persist in soil for extended periods and be transferred to water and cultivated crops [61]. Post-harvest handling is a significant challenge in many sesame-producing countries. An important post-harvest treatment of sesame seeds is drying to reduce the moisture content of seeds and prevent spoilage during storage. In several producing countries, this process usually occurs on the farm, under the sun, or in the open, exposing sesame seeds to hazards in the farm environment [14,36]. Potential sources of enteric pathogens include contaminated aerosols or dust, manure and animal droppings, and the harvest stage, which are increasingly considered critical for Salmonella contamination [48,51]. Many sesame-based products such as halva and tahini undergo further processing, e.g., cooking or the addition of sugar, which should inhibit the growth of pathogens like Salmonella. Therefore, cross-contamination from food handlers is also a possible source of contamination where good manufacturing practices are not utilised.

Other pathogenic or indicator bacteria have been linked to products from sesame seeds. Tahini contaminated with Listeria monocytogenes has been recalled from retail outlets in New Zealand [62], and other Listeria species have been isolated from hummus [63]. In addition, survival challenge studies have shown that L. monocytogenes can survive in sesame seed products under various environmental conditions and should be considered a safety concern [64,65]. Bacillus spp. including B. cereus, has also been linked to retailed sesame seeds [56,55]. Compaore et al. [52] evaluated the sanitary quality of sesame seeds and sesame based RTE foods in Burkina Faso. Although they did not detect any pathogenic Escherichia coli or Salmonella in the 75 samples collected, more than 30 % of the samples did not meet the microbiological criteria for dehydrated products.

Food safety remains a significant global public health challenge. The World Health Organisation (WHO) estimates that 1 in 10 people fall ill, and over 400,000 people, mainly under the age of 5, die each year after eating contaminated food [66]. The role of food as a vehicle for the transmission of biological hazards is well documented, and in an increasingly complex and global food chain, safeguarding the health of consumers, both domestic and international, remains a crucial goal. Salmonella outbreaks linked to sesame are a significant public health concern. Results from large-scale surveillance studies suggest that the prevalence of pathogenic organisms in sesame is low [49,50]. However, there are only a few of these studies and surveillance data from producing countries is sparse. Many sesame-based foods are sold as RTE with a long shelf life, which may put consumers' health at risk [46].

Furthermore, more information must be provided on the microbiological quality and safety of raw and processed sesame marketed for domestic consumption in producing countries. Most reports on microbial hazards and foodborne outbreaks linked to sesame are from importing countries [48]. In addition, very few studies investigate the whole supply chain to assess and evaluate critical control points to reduce contamination (Table 2). These are significant research gaps that require further investigation.

4 Chemical hazards in sesame seeds

4.1 Mycotoxins

Mycotoxins are toxic secondary metabolites of fungal species mainly belonging to the genera Aspergillus, Fusarium and Penicillium. These natural contaminants of food and feed are a growing public health concern, especially in low and middle-income countries [[67], [68], [69], [70]]. The most widely recognised classes of mycotoxins of concern are aflatoxins (AF), ochratoxin A (OTA), fumonisins, deoxynivalenol (DON) and other trichothecenes, and zearalenone (ZEA) [[71], [72], [73]].

Aspergillus flavus and A. parasiticus are the primary producers of aflatoxins [74]. Aflatoxin exposure can lead to acute aflatoxicosis, and long-term exposure is a risk factor for hepatocellular carcinoma [75]. Aflatoxin B1 (AFB1) is considered the most toxic and has been classified as a Group 1 carcinogen by the International Agency for Research on Cancer [76]. Contamination with multiple mycotoxins occurs frequently and can lead to severe health problems for consumers as the cytotoxic effects can impair the function of several organs, such as the liver and kidney, as well as the immune and nervous systems [77,78]. Chronic exposure to mycotoxins has also been associated with childhood stunting [79,80].

The frequent isolation of fungal species which have the potential to produce mycotoxins, particularly during the storage of sesame seeds, is a cause for concern. Aspergillus flavus and Fusarium spp. were reported as the dominant fungi in retailed sesame seeds in Nigeria [81]. Ajmal et al. [82] reported an increase in the prevalence of Aspergillus flavus and the concentration of aflatoxins during the storage of sesame seeds.

Sesame seeds are susceptible to fungal contamination at different stages of production and processing. The farm environment can be a source of fungal spores. Post-harvest storage of sesame seeds is common as sesame cultivation is seasonal, and storage provides supply between harvests or before seeds can be exported [35,83]. The storage period can range from a few weeks to several months [84]. Harvested produce is usually stored in non-hermetic packaging and non-climate-controlled facilities, which can support microbial growth. Temperature and water activity are the major extrinsic factors influencing fungal growth and mycotoxin production in food [85,86]. Storage at high humidity may increase water activity. Many sesame-producing countries are in tropical regions, and the warmer temperatures may provide suitable conditions for any fungal spores in the seeds to germinate during storage, thus producing mycotoxins [82,87,88].

Exposure to mycotoxins in food and feed is a major issue for human and animal health, nutrition, and the food trade [89]. International, regional, and national agencies have set maximum tolerable limits (MTLs) for mycotoxins in food to mitigate dietary exposure to mycotoxins and safeguard public health. For example, the European Commission has maximum levels for AFB1, total aflatoxins and ochratoxin A at 2, 4 and 5 μg/kg, respectively [90], while the United States Food and Drug Administration (U.S. FDA) recommends a maximum limit of 20 μg/kg for aflatoxins in foods intended for human consumption [91].

Several studies have reported a low prevalence of mycotoxins in sesame (Table 3). Ezekiel et al. [84] demonstrated that no detectable aflatoxins or fumonisins were present in sesame seeds collected from farmers (stored for less than 30 days after harvest) in Nigeria. These seeds also complied with international standards for regulated mycotoxins. These data corroborate results by Pongpraket et al. [23], where only 2 out of 200 (1 %) samples of retailed sesame seeds in Thailand were above the European Commission (EC) regulatory limits for aflatoxins. Tabata et al. [92] observed aflatoxins in 5 of 47 (10.6 %) sesame samples in Japan, noting concentrations of AFB1 between 0.6 and 2.4 μg/kg. Similarly, Hosseininia et al. [93] observed that 50 % of 269 samples from five shipments of sesame seeds imported into Iran contained less than 1 μg/kg of total aflatoxins. Esan et al. [94] reported a prevalence of 12 % and 7 % for total aflatoxins and Fumonisin B1, respectively, in sesame samples collected from retail markets in Nigeria. Ochratoxin A (OTA) was not detected in any of the samples in the study. It should be noted that in most of these studies, only specific mycotoxins were investigated. The full spectrum of mycotoxins and fungal metabolites in food products must be determined to accurately assess dietary mycotoxin exposure from consuming such foods. Furthermore, consuming foods contaminated with multiple mycotoxins, even at low concentrations over a prolonged period, may pose a health risk due to the possible synergistic effects of metabolite combinations [72,95].Table 3Occurrence and contamination level of mycotoxins in sesame seeds and sesame-based products.

TableSesame product	Mycotoxin typea	Samples (N)	Positive samples (n)	Number of samples > MTLb	Mean (μg/kg)	Range (μg/kg)	Analytical methodc	Country	Reference	
Harvested seeds	AFB1	100	92	24	21.6	1.2–60	TLC	Pakistan	[82]	
Stored seeds	AFB1	100	99	80	30.6	15–60				
Seeds	AF	46	23	7	13.67	0.79–60.5	Scanning densitometer	Nigeria	[81]	
Seeds	AFB1	182	33	9	1.62		HPLC	Iran	[96]	
Seeds (Black)	AF	955	203			0.2–16	TLC	Myanmar	[87]	
Seeds (White)	AF	110	35			0.3–7				
Seeds	AF	30	10	5	2.95	0.9–61.8	ELISA	Uganda	[97]	
OTA	30	26	1	1.45	0.1–3.1				
DON	30	21		194.4	0.8–955.3				
Seeds	AFB1	96	96	96	6.36	3.95–11.75	HPLC	Nigeria	[98]	
Seeds	AF	59	7	5	16.9	0.29–88.5	LC-MS/MS	Nigeria	[94]	
FB1	59	4		13.0	5.60–24.0				
Seeds	DON	17	15		28	8–76	LC-MS/MS	Nigeria	[84]	
Seeds	AFB1	24	3		3.6	0.4–7.2	LC-MS/MS	Nigeria	[22]	
FB1	24	5		17.3	7.3–26.7				
DON	24	14		78.3	28–171				
Sesame product	Mycotoxin typea	Samples (n)	Positive samples	Number of samples > MTLb	Mean (μg/kg)	Range (μg/kg)	Analytical methodc	Country	Reference	
Seeds	AF	40	22	15	1.95		HPLC	Iran	[99]	
Tahini	AF	40	18	14	1.10					
Tahini halva	AF	40	13	11	0.72					
Seeds	AF	269	136	8	1.43	0.4–48.18	HPLC	Iran	[93]	
Seeds, Tahini, Tahini halva, Sesame bars	AFB1	30	23	8		0.1–8.6	HPLC	Greece	[100]	
Paste	AFB1	100	37	12	4.31	0.39–20.45	Fluorimetry, LC	China	[101]	
AF			9	6.75	0.54–56.89				
Seeds	OTA	19	19	13	8.14	1.90–15.66	HPLC	Nigeria	[102]	
Seeds	AFB1	200	10	10	1.44	0.84–2.17	LC-MS/MS	Thailand	[23]	
BEA		35		8.89	1.39–37.8				
Seeds	AFB1	8	7		0.90	0.54–1.82	ELISA	Malaysia	[103]	
Seeds	AFB1	28	25	25	33.7		HPLC	Egypt	[104]	
Tahini	AFB1	117	39	25	6.55	0.2–238.1	HPLC	Egypt	[105]	
Seeds	AFB1	47	5			0.6–2.4	HPTLC	Japan	[92]	
(−): Data not available.

a AF: Total Aflatoxin; AFB1: Aflatoxin B1; BEA: Beauvericin; DON: Deoxynivalenol; FB1: Fumonisin B1; OTA: Ochratoxin A.

b MTL: Maximum Tolerable Limit based on European Commission (EC, 2006) regulations for Total AF (4 μg/kg), AFB1 (2 μg/kg), OTA (5 μg/kg).

c HPLC: High-Performance Liquid chromatography; HPTLC: High-Performance Thin Layer Chromatography; LC: Liquid chromatography; MS: Mass spectrophotometry; TLC: Thin Layer Chromatography.

An analysis of aflatoxin contamination in sesame seeds in this report has shown that contaminated samples at the retail or household level regularly exceed regulatory limits (Table 3). Elaigwu et al. [98] observed concentrations of AFB1 above 2 μg/kg in all sesame seed samples (n = 96) collected in Nigeria. Heshmati et al. [99] reported that 25 % of sesame seeds from the Iranian market were contaminated with AFB1 above the EC ML. In the same study, 18 % and 15 % of tahini and tahini-halva samples, respectively, were above the EC ML for AFB1. Overall, 38 %, 35 % and 11 % of the sesame seeds, tahini, and tahini-halva samples contained total aflatoxins above the EC limit. A study in China investigating the occurrence of aflatoxins in sesame paste collected from both small-scale and industrial manufacturers noted that 37 % of the samples were contaminated with AFB1. The maximum AFB1 concentration recorded was 20.45 μg/kg, and 12 % of samples had concentrations above 2 μg/kg [101]. Echodu et al. [97] observed that 13 % of sesame seed samples collected from households in Northern Uganda exceeded the EC ML for aflatoxins. In tahini samples from Egypt, 21 % exceeded the Egyptian ML of 2 μg/kg [105].

Ochratoxin has been demonstrated to be genotoxic and carcinogenic in animals with the kidney as the primary target organ, and it is classified as a Group 2B possible carcinogen [106,107]. There are few reports of OTA contamination of sesame seeds. Makun et al. [102] investigated the prevalence of OTA in sesame samples from Nigeria. They reported that all sesame seed samples in their study (n = 19) were contaminated with OTA, and EC limits were exceeded in 13 % of the samples. This contrasts with Echodu et al. [97], where only 3 % of collected samples had OTA concentrations exceeding EC limits.

Only a few major producing countries have set regulatory limits for mycotoxins, specifically for sesame seeds and products, and where these exist, focus on international trade [108]. In addition to potential risks to consumer health, mycotoxin contamination of sesame seeds could have severe economic consequences due to border rejections and recalls.

4.2 Pesticides

Controlling the growth of microorganisms and pests in sesame is critical for improving food quality and safety. Some previously used biological control methods for reducing microbial hazards in harvested sesame include irradiation, fumigation with carbon dioxide (CO2) or propylene oxide, and the addition of salts [25,109]. Furthermore, plant protection products, such as pesticides, are used at different stages of cultivation to reduce post-harvest losses due to pest infestation and pathogens. However, there is growing concern about the potential adverse effects of pesticide residues on consumers and the environment [110,111].

Recently, global attention was drawn to the issue of pesticide contamination due to consumer exposure to ethylene oxide after its detection in sesame seeds imported into Europe from India in 2020 [112]. The use of ethylene oxide as a plant protection product is not approved in the EU as it has been classified as a Group 1 carcinogen [113]. However, ethylene oxide was detected at over 1000 times the maximum residue level (MRL) of 0.05 mg/kg [114,115]. This incident led to an unprecedented recall and withdrawal of sesame-based foods across the Member States and non-EU Member States [24]. As a result, new legislation has been implemented to increase import controls on sesame originating from India [15].

Between January 2020 and March 2024, there were 419 notifications regarding pesticide residues in sesame seeds in the EU RASFF system. Most of the notifications concerned sesame seeds originating from India (349, 83.3 %). The main contaminant was ethylene oxide (312 out of 349) and its derivatives, 2-chloroethanol, chlorate and iprobenfos. There have been reduced notifications from India since 2020 (262 notifications in 2020, 78 notifications in 2021, 8 notifications in 2022 and 1 notification in 2023). This is probably because of the increased frequency of checks and import control by importing countries. As of April 2024, there are only 5 notifications regarding pesticide residues in sesame seeds entering the EU for 2024. Four of the notifications were from Nigeria, with Chlorpyrifos (more than two times the MRL) and Chlorate (more than 8 times the MRL) reported in sesame seeds from Nigeria [116].

Some pesticide residues, including lindane, chlorpyriphos, and metalaxyl, have been observed in sesame seeds and oil [117,118]. Pesticide residues are not only found in the sesame seeds but could also be carried over into the processed products. For example, ethylene oxide was detected in caramelised nuts made with sesame seeds from Nigeria [119], in baking mixes made with sesame seeds from India [120], in spice mixes made with sesame seeds from India [121] and in bread baking mixes made with sesame seeds from India [122]. A residue of ethylene oxide, 2-chloroethane, was also detected in baking mixes made with sesame seeds from Nigeria [123].

The presence and persistence of pesticides in sesame seeds and their products raise the urgent need for research and development of alternative pest control strategies. This will eliminate the need to use these unsafe chemicals in foods. Furthermore, there have been repeated notifications of ethylene oxide in sesame seeds imported into the EU. This suggests a need for continuous monitoring and surveillance of these chemicals in sesame seeds and their products. This is particularly important in producing countries for which there is limited data.

4.3 Allergens

Sesame allergy is a growing concern as it triggers hypersensitivities that lead to symptoms including vomiting, diarrhoea, contact dermatitis and systematic anaphylaxis [124,125]. Sesame allergens have been classified into three major groups: lipid, protein, and unknown allergens [126]. Protein allergens are classified into eight groups, Ses i 1 to Ses i 8 and are associated with IgE-mediated immediate hypersensitivity reactions. Lipid allergens initiate both immediate (seeds) and delayed (oil) hypersensitivity reactions [127].

Reports on the prevalence of sesame allergies globally vary widely from about 0.1 % to 0.8 %, as this depends on how much sesame is consumed within the local diet [125,128,129]. Sesame has been recognised as a source of food allergens in the Middle East, where it is used extensively in the diet. Sesame ranked third as the most common food allergy after eggs and milk in Israeli children [126]. A study in Saudi Arabia noted that sesame was the third most common cause of anaphylaxis, accounting for 15 % of cases prescribed antihistamines over a 2-year period [130]. In Turkey, an estimated 20 % of children with food allergies are allergic to sesame [131]. However, sesame allergies are reported in several other parts of the world. For example, although sesame-induced anaphylaxis rates were reported to be higher in the Middle East than in North America [132], sesame allergy is a substantial burden in the United States. An estimated 0.49 % of the population report a current sesame allergy, and 17 % of children with an IgE-mediated food allergy are estimated to have a sesame allergy [133,134]. Consequently, it is thought that the burden of sesame allergies may be higher than reported [135].

Several countries have established regulatory food labelling on products containing sesame to protect consumers and reduce the risk of unintentional exposure to sesame allergens. Since 2023, it has been required by law in the United States to label sesame as an allergen on food and dietary supplement packaging. This requirement also exists in the European Union, Canada, Australia, New Zealand, and other parts of the world [136]. In addition, a joint FAO-WHO Expert Committee recommended that sesame be considered a priority allergen [137].

There is scarce information on the prevalence of sesame allergies and their regulation in many sesame-producing countries worldwide, particularly those in Africa. This could be because sesame seeds are produced for export rather than local consumption. However, it has also been noted that there are significant data gaps on food allergens in many low-resource countries that bear a significant burden of other food-related challenges, e.g., malnutrition [138].

As observed with microbial hazards, there is limited information on the prevalence and human health risks of chemical hazards in sesame seeds and sesame-based products. Inadequate food safety and quality regulatory and monitoring systems and a lack of public awareness are important limitations in many producing countries [87,97]. To address this critical food safety issue, a better understanding of the routes of contamination of sesame seeds and routine surveillance in producing countries is required. This will serve as a baseline for developing evidence-based strategies for risk assessment and identifying intervention strategies to reduce exposure to these hazards.

5 Discussion and recommendations

Sesame seeds have high economic value and immense potential in enabling producing countries to achieve Sustainable Development Goals focused on poverty alleviation and food security. Sesame is mainly grown as an export crop in producing countries, providing employment and income for producers and processors. While the global sesame market is anticipated to grow [139], compliance with food safety regulations remains a significant barrier to the international trade of sesame seeds. Some major hazards affecting the sesame seed trade identified in this review include Salmonella mycotoxins and pesticide residues.

Currently, there is a limited understanding of which stages of sesame production and processing are most vulnerable to contamination. Many studies investigating the occurrence of hazards in sesame focus on the storage and retail stages of the value chain. During production, contaminants can be introduced through pollution from the farm environment, the use of contaminated soil amendments, irrigation water and pesticide use [140]. Further contamination could occur due to poor harvesting, drying, storage and transportation practices and unhygienic conditions during the processing and retail stages [98,141].

There is a dearth of data from sesame-producing countries describing the link between local agricultural practices, particularly at the pre-harvest stage, and the occurrence of microbial and chemical hazards in sesame. Although some good agricultural practices have been recommended to improve the quality of sesame seeds [142], systematic investigations are needed to identify the critical points where contamination occurs in the value chain. This information is important to better target control strategies to minimise the contamination of sesame. This will contribute to food security for many smallholder farmers in producing countries and overall food safety for consumers.

Research could also focus on infrastructural interventions such as alternative drying procedures and hermetic technologies for seed storage [142,143]. In humid climates, in addition to drying, seeds need to be packed in moisture-proof packaging to prevent rehydration [144]. Hermetic technologies such as the Purdue Improved Crop Storage [145] and Super Grain Pro [146] are moisture-proof and prevent oxygen from getting into the seeds. Microorganisms and pests require oxygen for respiration; therefore, oxygen concentrations are reduced to concentrations which cannot support their growth [144]. This is particularly important as conditions that support fungal growth will lead to mycotoxin contamination. In addition, better pest control reduces the need for the use and abuse of pesticides. Consequently, hermetic packaging has been promoted in many low-resource, tropical countries to reduce post-harvest losses of several crops [147,148]. There are relatively few studies exploring the use of hermetic packaging for sesame seed storage that focus on microbial hazards [143]. Sesame seeds stored in hermetic bags had lower levels of fungal infestation and mycotoxins compared to standard packaging in polypropylene and jute bags over a six-month storage period [149]. The effect of environmental factors, storage periods and affordable packaging technologies on sesame safety and quality is an important research priority in producing countries.

Regular surveillance is required to detect contamination sources and measure the effectiveness of mitigation strategies for mycotoxin contamination. For pesticides in sesame seeds, there is a need to conduct a risk assessment of their presence in sesame seeds and how these are carried over to sesame-based products. Furthermore, it is essential to develop and employ novel rapid detection methods for determining contaminants across the value chain to mitigate post-harvest and economic losses where possible. Alternative pest management strategies, which are sustainable and environmentally-friendly, should be developed and deployed to avoid using unapproved pesticides in the sesame seed value chain.

The safety of sesame seeds for domestic consumption must also be prioritised as a research need in producing countries. Knowledge transfer between researchers, producers, and processors of sesame seeds on food safety is essential. This will give producers and processors the knowledge and tools to produce sesame seeds that meet the food safety requirements for local consumption and the international market. Researchers should regularly network with stakeholders in the sesame seeds value chain to identify emerging food safety challenges and make these research priorities for action (Fig. 4).Fig. 4 Recommendations for reducing microbial and chemical hazards in the sesame value chain.

Fig. 4

Funding

AO gratefully acknowledges the award of a PhD scholarship by the Tertiary Education Trust Fund (TETFund), Nigeria.

Data availability

All data to support the conclusions in this review have been provided in the manuscript.

CRediT authorship contribution statement

Amarachukwu Anyogu: Writing – review & editing, Writing – original draft, Visualization, Supervision, Project administration, Conceptualization. Yinka M. Somorin: Writing – review & editing, Writing – original draft, Visualization, Supervision, Conceptualization. Abigail Oluseye Oladipo: Writing – original draft. Saki Raheem: Writing – review & editing, Writing – original draft.

Declaration of competing interest

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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References

1 Wacal C. Basalirwa D. Okello-Anyanga W. Murongo M.F. Namirembe C. Malingumu R. Analysis of sesame seed production and export trends; challenges and strategies towards increasing production in Uganda OCL 28 4 2021 10.1051/ocl/2020073
2 Abdiani N. Kolahi M. Javaheriyan M. Sabaeian M. Effect of storage conditions on nutritional value, oil content, and oil composition of sesame seeds Journal of Agriculture and Food Research 16 2024 101117 10.1016/j.jafr.2024.101117
3 Wei X. Liu K. Zhang Y. Feng Q. Wang L. Zhao Y. Genetic discovery for oil production and quality in sesame Nat. Commun. 6 2015 8609 10.1038/ncomms9609 26477832
4 Langyan S. Yadava P. Sharma S. Gupta N.C. Bansal R. Yadav R. Kalia S. Kumar A. Food and nutraceutical functions of sesame oil: an underutilised crop for nutritional and health benefits Food Chem. 389 2022 132990 10.1016/j.foodchem.2022.132990
5 Rafiee S. Faryabi R. Yargholi A. Zareian M.A. Hawkins J. Shivappa N. Shirbeigi L. Effects of sesame consumption on inflammatory biomarkers in humans: a systematic review and meta-analysis of randomized controlled trials Evidence-based Complementary and Alternative Medicine, eCAM 2021 6622981 10.1155/2021/6622981
6 Pathak N. Rai A.K. Kumari R. Bhat K.V. Value addition in sesame: a perspective on bioactive components for enhancing utility and profitability Phcog. Rev. 8 2014 147 155 10.4103/0973-7847.134249 25125886
7 Wang X. You J. Liu A. Qi X. Li D. Zhao Y. Variation in melatonin contents and genetic dissection of melatonin biosynthesis in sesame Plants 11 2022 2005 10.3390/plants11152005 35956483
8 Wang Z. Zhou Q. Dossou S.S.K. Zhou R. Zhao Y. Zhou W. Genome-wide association study uncovers loci and candidate genes underlying phytosterol variation in sesame (Sesamum indicum L.) Agriculture 12 2022 392 10.3390/agriculture12030392
9 Mostashari P. Mousavi Khaneghah A. Sesame seeds: a nutrient-rich superfood Foods 13 8 2024 1153 10.3390/foods13081153 38672826
10 Pathak N. Bhaduri A. Rai A.K. Sesame: bioactive compounds and health benefits Mérillon J.-M. Ramawat K.G. Bioactive Molecules in Food 2019 Springer International Publishing 181 200 10.1007/978-3-319-78030-6_59
11 CBI, Ministry of Foreign Affairs, The European Market Potential for Sesame Seeds. https://www.cbi.eu/market-information/grains-pulses-oilseeds/sesame-seeds/market-potential2020. May 2023.
12 Abourehab M.A.S. Khames A. Genedy S. Mostafa S. Khaleel M.A. Omar M.M. El Sisi A.M. Sesame oil-based nanostructured lipid carriers of nicergoline, intranasal delivery system for brain targeting of synergistic cerebrovascular protection Pharmaceutics 13 2021 581 10.3390/pharmaceutics13040581 33921796
13 Teklu D.H. Shimelis H. Tesfaye A. Abady S. Appraisal of the sesame production opportunities and constraints, and farmer-preferred varieties and traits, in eastern and southwestern Ethiopia Sustainability 13 2021 11202 10.3390/su132011202
14 Dossa K. Konteye M. Niang M. Doumbia Y. Cissé N. Enhancing sesame production in West Africa's Sahel: a comprehensive insight into the cultivation of this untapped crop in Senegal and Mali Agric. Food Secur. 6 2017 68 10.1186/s40066-017-0143-3
15 European Commission Commission implementing Regulation (EU) 2020/1540 of 22 October 2020 amending Implementing Regulation (EU) 2019/1793 as regards sesamum seeds originating in India Orkesterjournalen L 353 23.10 2020 4 2020
16 Somorin Y.M. Odeyemi O.A. Ateba C.N. Salmonella is the most common foodborne pathogen in african food exports to the European union: analysis of the rapid Alert system for food and feed (1999–2019) Food Control 123 2021 107849 10.1016/j.foodcont.2020.107849
17 European Commission Directorate-General for Health and Food Safety, RASFF Annual Report 2019 2020 Publications Office https://op.europa.eu/en/publication-detail/-/publication/2c5c7729-0c31-11eb-bc07-01aa75ed71a1/language-en May 2022
18 Dada A.C. Somorin Y.M. Ateba C.N. Onyeaka H. Anyogu A. Kasan N.A. Odeyemi O.A. Microbiological hazards associated with food products imported from the Asia-Pacific region based on analysis of the Rapid Alert System for Food and Feed (RASFF) notifications Food Control 129 2021 108243 10.1016/j.foodcont.2021.108243
19 Centers for Disease Control and Prevention (CDC) Multistate outbreak of Salmonella serotype Bovismorbificans infections associated with hummus and tahini—United States, 2011 MMWR (Morb. Mortal. Wkly. Rep.) 61 46 2012 944 947 23169315
20 Meinen A. Simon S. Banerji S. Szabo I. Malorny B. Borowiak M. Salmonellosis outbreak with novel Salmonella enterica subspecies enterica serotype (11:z41:e,n,z15) attributable to sesame products in five European countries, 2016 to 2017 Euro Surveill. 24 36 2019 1800543 10.2807/1560-7917.ES.2019.24.36.1800543
21 Unicomb L.E. Simmons G. Merritt T. Gregory J. Nicol C. Jelfs P. Sesame seed products contaminated with Salmonella: three outbreaks associated with tahini Epidemiol. Infect. 133 2005 1065 1072 10.1017/S0950268805004085 16274503
22 Fapohunda S.O. Anjorin T.S. Sulyok M. Krska R. Profile of major and emerging mycotoxins in sesame and soybean grains in the Federal Capital Territory, Abuja, Nigeria European Journal of Biological Research 8 2018 121 130
23 Pongpraket M. Poapolathep A. Wongpanit K. Tanhan P. Giorgi M. Zhang Z. Li P. Poapolathep S. Exposure assessment of multiple mycotoxins in black and white sesame seeds consumed in Thailand J. Food Protect. 83 7 2020 1198 1207 10.4315/JFP-19-597
24 European Commission RASFF – the Rapid Alert System for Food and Feed – Annual Report 2020 2021 Publications Office of the European Union Luxembourg https://food.ec.europa.eu/system/files/2021-08/rasff_pub_annual-report_2020.pdf June 2022
25 Al-Bachir M. Some microbial, chemical, and sensorial properties of gamma-irradiated sesame (Sesamum indicum L.) seeds Food Chem. 197 2016 191 197 10.1016/j.foodchem.2015.10.094 26616940
26 Andargie M. Vinas M. Rathgeb A. Möller E. Karlovsky P. Lignans of sesame (Sesamum indicum L.): a comprehensive review Molecules 26 2021 883 10.3390/molecules26040883 33562414
27 Myint D. Gilani S.A. Kawase M. Watanabe K.N. Sustainable sesame (Sesamum indicum L.) production through improved technology: an overview of production, challenges, and opportunities in Myanmar Sustainability 12 9 2020 3515 10.3390/su12093515
28 Olaimat A.N. Osaili T.M. Al-Holy M.A. Al-Nabulsi A.A. Obaid R.S. Alaboudi A.R. Ayyash M. Holley R. R. Microbial safety of oily, low water activity food products: a review Food Microbiol. 92 2020 103571 10.1016/j.fm.2020.103571
29 Mordor Intelligence Sesame seeds market – growth Trends, COVID-19 Impact and Forecasts 2024 https://www.mordorintelligence.com/industry-reports/sesame-seeds-market July 2024
30 FAOSTAT, FAOSTAT Statistical Database 2024 https://www.fao.org/faostat/en/#home July 2024
31 National Bureau of Statistics Foreign Trade in Goods Statistics, Q3 2023 2023 https://www.nigerianstat.gov.ng/pdfuploads/Q3_2023_Foreign_Trade_Statistics_Report.pdf July 2024
32 FAO Analysis of price incentives for sesame seed in Ethiopia for the time period 2005–2012 Kuma Worako T. MasAparisi A. Lanos B. Technical Notes Series, MAFAP 2015 Rome by
33 Sadiq M.S. Singh I.P. Ahmad M.M. Sesame as a potential cash crop: an alternative source of foreign exchange earnings for Nigeria Sri Lanka Journal of Food and Agriculture 6 2020 7 21 10.4038/sljfa.v6i1.78
34 Gebremedhn M.B. Tessema W. Gebre G.G. Mawcha K.T. Assefa M.K. Value chain analysis of sesame (Sesamum indicum L.) in Humera district, Tigray, Ethiopia Cogent Food Agric. 5 2019 1705741 10.1080/23311932.2019.1705741
35 Myint T. Aung Y.M. Assessment of value chain management of sesame in Pwint Phyu township, Magway region, Myanmar J. Econ. Sustain. Dev. 10 2019 117 128 10.7176/JESD
36 Neme K. Tola Y.B. Mohammed A. Tadesse E. Postharvest handling practices and on farm estimation of losses of sesame (Sesamum indicum L.) seeds: the case of two wollega zones in Ethiopia East African Journal of Sciences 14 2020 23 38
37 Beuchat L.R. Komitopoulou E. Beckers H. Betts R.P. Bourdichon F. Fanning S. Low–water activity foods: increased concern as vehicles of foodborne pathogens J. Food Protect. 76 2013 150 172 10.4315/0362-028X.JFP-12-211
38 Igo M.J. Schaffner D.W. Models for factors influencing pathogen survival in low-water activity foods from literature data are highly significant but show large unexplained variance Food Microbiol. 98 2021 103783 10.1016/j.fm.2021.103783
39 Torlak E. Sert D. Serin P. Fate of Salmonella during sesame seeds roasting and storage of tahini Int. J. Food Microbiol. 163 2013 214 217 10.1016/j.ijfoodmicro.2013.03.010 23562834
40 Xu Y. Li R. Li K. Yu J. Bai J. Wang S. Inactivation of inoculated Salmonella and natural microflora on two kinds of edible seeds by radio frequency heating combined with cinnamon oil vapour LWT 154 2022 112603 10.1016/j.lwt.2021.112603
41 Harris L.J. Yada S. Beuchat L.R. Danyluk M.D. Outbreaks of foodborne illness associated with the consumption of tree nuts, peanuts, and sesame seeds (version 2) [Table and references] Outbreaks from Tree Nuts, Peanuts, and Sesame Seed 2024 https://ucfoodsafety.ucdavis.edu/low-moisture-foods/nuts-and-nut-pastes July 2024
42 European Centre for Disease Prevention and Control, European Food Safety Authority Multi-country outbreak of multiple Salmonella enterica serotypes linked to imported sesame-based products –14 October 2021 https://efsa.onlinelibrary.wiley.com/doi/pdf/10.2903/sp.efsa.2021.EN-6922 2021 March 2022
43 Paine S. Thornley C. Wilson M. Dufour M. Sexton K. Miller J. King G. Bell S. Bandaranayake D. Mackereth G. An outbreak of multiple serotypes of Salmonella in New Zealand linked to consumption of contaminated tahini imported from Turkey Foodborne Pathogens and Disease 11 11 2014 887 892 10.1089/fpd.2014.1773 25393669
44 Centers for Disease Control and Prevention Outbreak of Salmonella infections linked to karawan brand tahini May 2019 https://www.cdc.gov/salmonella/concord-05-19/index.html 2019 June 2022
45 Tanguay F. Vrbova L. Anderson M. Whitfield Y. Macdonald L. Tschetter L. Hexemer A. Salmonella reading investigation team, outbreak of Salmonella reading in persons of eastern mediterranean origin in Canada, 2014-2015 Canada Communicable Disease Report = Releve Des Maladies Transmissibles Au Canada 43 1 2017 14 20 10.14745/ccdr.v43i01a03 29770042
46 D'Oca M.C. Di Noto A.M. Bartolotta A. Parlato A. Nicastro L. Sciortino S. Cardamone C. Assessment of contamination of Salmonella spp. in imported black pepper and sesame seed and salmonella inactivation by gamma irradiation Italian Journal of Food Safety 10 1 2021 8914 10.4081/ijfs.2021.8914 33907684
47 Juarez Arana C.D. Martinez Peneche R.A. Martinez M.G. Iturriaga M.H. Microbiological profile, incidence, and behavior of Salmonella on seeds traded in Mexican markets J. Food Protect. 84 1 2020 99 105 10.4315/JFP-19-595
48 Compaore M.K.A. Yougbaré V.M. Dembele R. Nikièma F. Elie K. Barro N. Retrospective study of the contamination of exported sesame by Salmonella species from 2007 to 2017 in Burkina Faso Afr. J. Agric. Res. 16 2020 1141 1147 10.5897/AJAR2020.14917
49 Van Doren J.M. Blodgett R.J. Pouillot R. Westerman A. Kleinmeier D. Ziobro G.C. Ma Y. Hammack T.S. Gill V. Muckenfuss M.F. Fabbri L. Prevalence, level, and distribution of Salmonella in shipments of imported capsicum and sesame seed spice offered for entry to the United States: observations and modelling results Food Microbiol. 36 2013 149 160 10.1016/j.fm.2013.05.003 24010593
50 Van Doren J.M. Kleinmeier D. Hammack T.S. Westerman A. Prevalence, serotype diversity, and antimicrobial resistance of Salmonella in imported shipments of spice offered for entry to the United States, FY2007-FY2009 Food Microbiol. 34 2013 239 251 10.1016/j.fm.2012.10.002 23541190
51 Brockmann S.O. Piechotowski I. Kimmig P. Salmonella in sesame seed products J. Food Protect. 67 1 2004 178 180 10.4315/0362-028X-67.1.178
52 Compaoré M.K.A. Bazie B.S.R. Nikiema M.E.M. Dakené V.M. Dembélé R. Kpoda D.S. Kabré E. Barro N. Assessment of the sanitary quality of ready to eat sesame, a low moisture street food from Burkina Faso BMC Microbiol. 21 2021 207 10.1186/s12866-021-02269-0 34238245
53 Willis C. Little C.L. Sagoo S. de Pinna E. Threlfall J. Assessment of the microbiological safety of edible dried seeds from retail premises in the United Kingdom with a focus on Salmonella spp Food Microbiol. 26 8 2009 847 852 10.1016/j.fm.2009.05.007 19835770
54 Alaouie Z. Hallal N. Alkhatib A. Khachfe H.M. Assessing the microbial quality of tahini (sesame paste) in Lebanon The Sixth International Conference on Global Health Challenges 2017 IARIA 20 24
55 Kato K. Komagome N. Mineki M. Boonmar S. Morita Y. Detection of Bacillus cereus and Gram-negative bacteria communities in commercial sesame in Japan Thai Journal of Veterinary Medicine 51 2021 1 5
56 Fay M. Salazar J.K. Ramachandran P. Stewart D. Microbiomes of commercially available pine nuts and sesame seeds PLoS One 16 6 2021 e0252605 10.1371/journal.pone.0252605
57 Zhang G. Hu L. Pouillot R. Tatavarthy A. Van Doren J.M. Kleinmeier D. Ziobro G.C. Melka D. Prevalence of Salmonella in 11 spices offered for sale from retail establishments and in imported shipments offered for entry to the United States J. Food Protect. 80 2017 1791 1805 10.4315/0362-028X.JFP-17-072
58 Department of Agriculture Water and the environment, Australian government imported food control order 2019 https://www.legislation.gov.au/F2019L01233/latest/text 2023 July 2024
59 European Commission Commission implementing regulation (EU) 2017/186 of 2 February 2017 Off. J. Eur. Union 60 2017 24
60 Olaimat A.N. Holley R.A. Factors influencing the microbial safety of fresh produce: a review Food Microbiol. 32 2012 1 19 10.1016/j.fm.2012.04.016 22850369
61 Jacobsen C.S. Bech T.B. Soil survival of Salmonella and transfer to freshwater and fresh produce Food Res. Int. 45 2012 557 566 10.1016/j.foodres.2011.07.026
62 Osaili T.M. Al-Nabulsi A. Inactivation of stressed Escherichia coli O157:H7 in tahini (sesame seeds paste) by gamma irradiation Food Control 69 2016 221 226 10.1016/j.foodcont.2016.05.009
63 Omar S.S. Dababneh B.F. Qatatsheh A.A. Abu-Romman S.M. Hawari A.D. Aladaileh S.H. The incidence of Listeria species and other indicator bacteria in some traditional foods sold in Karak city, Jordan J. Food Agric. Environ. 9 2 2011 79 81
64 Salazar J.K. Natarajan V. Stewart D. Fay M. Gonsalves L.J. Mhetras T. Sule C. Tortorello M.L. Listeria monocytogenes growth kinetics in refrigerated ready-to-eat dips and dip components PLoS One 15 6 2020 e0235472 10.1371/journal.pone.0235472
65 Salazar J.K. Natarajan V. Stewart D. Suehr Q. Mhetras T. Gonsalves L.J. Tortorello M.L. Survival kinetics of Listeria monocytogenes on chickpeas, sesame seeds, pine nuts, and black pepper as affected by relative humidity storage conditions PLoS One 14 12 2019 e0226362 10.1371/journal.pone.0226362
66 World Health Organization Factsheet on food safety https://www.who.int/news-room/fact-sheets/detail/food-safety 2022 July 2024
67 Darwish W.S. Ikenaka Y. Nakayama S.M.M. Ishizuka M. An overview on mycotoxin contamination of foods in Africa J. Vet. Med. Sci. 76 6 2014 789 797 10.1292/jvms.13-0563 24572628
68 Imade F. Ankwasa E.M. Geng H. Ullah S. Ahmad T. Wang G. Zhang C. Dada O. Xing F. Zheng Y. Liu Y. Updates on food and feed mycotoxin contamination and safety in Africa with special reference to Nigeria Mycology 12 4 2021 245 260 10.1080/21501203.2021.1941371 34900380
69 Kebede H. Liu X. Jin J. Xing F. Current status of major mycotoxins contamination in food and feed in Africa Food Control 110 2020 106975 10.1016/j.foodcont.2019.106975
70 Mehta R.V. Wenndt A.J. Girard A.W. Taneja S. Ranjan S. Ramakrishnan U. Martorell R. Ryan P.B. Rangiah K. Young M.F. Risk of dietary and breastmilk exposure to mycotoxins among lactating women and infants 2–4 months in northern India Matern. Child Nutr. 17 2 2021 e13100 10.1111/mcn.13100
71 Manizan A.L. Oplatowska-Stachowiak M. Piro-Metayer I. Campbell K. Koffi-Nevry R. Elliott C. Akaki D. Montet D. Brabet C. Multi-mycotoxin determination in rice, maize, and peanut products most consumed in Côte d'Ivoire by UHPLC-MS/MS Food Control 87 2018 22 30 10.1016/j.foodcont.2017.11.032
72 Misihairabgwi J.M. Ezekiel C.N. Sulyok M. Shephard G.S. Krska R. Mycotoxin contamination of foods in Southern Africa: a 10-year review (2007–2016) Crit. Rev. Food Sci. Nutr. 59 1 2019 43 58 10.1080/10408398.2017.1357003 28799776
73 Probst C. Bandyopadhyay R. Cotty P.J. Diversity of aflatoxin-producing fungi and their impact on food safety in sub-Saharan Africa Int. J. Food Microbiol. 174 2014 113 122 10.1016/j.ijfoodmicro.2013.12.010 24480188
74 Norlia M. Jinap S. Nor-Khaizura M.A.R. Radu S. Samsudin N.I.P. Azri F.A. Aspergillus section flavi and aflatoxins: occurrence, detection, and identification in raw peanuts and peanut-based products along the supply chain Front. Microbiol. 10 2019 https://www.frontiersin.org/article/10.3389/fmicb.2019.02602
75 Wild C.P. Miller J.D. Groopman J.D. Human exposure to aflatoxins and fumonisins, Chapter 1 Mycotoxin Control in Low- and Middle-Income Countries 2015 International Agency for Research on Cancer https://www.ncbi.nlm.nih.gov/books/NBK350555/
76 International Agency for Research on Cancer Aflatoxins. Chemical agents and related occupations. A review of human carcinogens IARC Monogr. Eval. Carcinog. Risks Hum. 100F 2012 225 248
77 De Ruyck K. De Boevre M. Huybrechts I. De Saeger S. Dietary mycotoxins, co-exposure, and carcinogenesis in humans: short review Mutation Research/Reviews in Mutation Research 766 2015 32 41 10.1016/j.mrrev.2015.07.003 26596546
78 EFSA Panel on Contaminants in the Food Chain Risk assessment of aflatoxins in food EFSA J. 18 3 2020 e06040 10.2903/j.efsa.2020.6040
79 Shirima C.P. Kimanya M.E. Routledge M.N. Srey C. Kinabo J.L. Humpf H.U. Wild C.P. Tu Y.K. Gong Y.Y. A prospective study of growth and biomarkers of exposure to aflatoxin and fumonisin during early childhood in Tanzania Environ. Health Perspect. 123 2015 173 178 10.1289/ehp.1408097 25325363
80 Andrews-Trevino J. Webb P. Shrestha R. Pokharel A. Acharya S. Chandyo R. Davis D. Baral K. Wang S. Xue K. Ghosh S. Exposure to multiple mycotoxins, environmental enteric dysfunction and child growth: results from the AflaCohort Study in Banke, Nepal Matern. Child Nutr. 18 2 2022 e13315 10.1111/mcn.13315
81 Apeh D.O. Ochai O. Aderemi A. Muhammad H. Saidu A. Joseph A. Henry A. Mailafiya S. Makun H. Mycotoxicological concerns with sorghum, millet and sesame in northern Nigeria J. Anal. Bioanal. Tech. 7 2016 336 10.4172/2155-9872.1000336
82 Ajmal M. Akram A. Hanif N.Q. Mukhtar T. Arshad M. Mycobiota isolation and aflatoxin B1 contamination in fresh and stored sesame seeds from rainfed and irrigated zones of Punjab, Pakistan J. Food Protect. 84 2021 1673 1682 10.4315/JFP-21-060
83 Baoua I.B. Amadou L. Abdourahmane M. Bakoye O. Baributsa D. Murdock L.L. Grain storage and insect pests of stored grain in rural Niger J. Stored Prod. Res. 64 2015 8 12 10.1016/j.jspr.2015.04.007
84 Ezekiel C.N. Sulyok M. Warth B. Krska R. Multi-microbial metabolites in fonio millet (acha) and sesame seeds in Plateau State, Nigeria Eur. Food Res. Technol. Z Lebensm. Unters. Forsch. 235 2012 285 293 10.1007/s00217-012-1755-2
85 Chuaysrinule C. Mahakarnchanakul W. Maneeboon T. Comparative study on the effect of temperature and water activity on Aspergillus flavus and Aspergillus carbonarius isolates growth and mycotoxin production on a chilli powder medium Cogent Food Agric. 6 1 2020 1782097 10.1080/23311932.2020.1782097
86 Gebremeskel A.F. Ngoda P.N. Kamau-Mbuthia E.W. Mahungu S.M. The sesame (Sesamum indicum L.) value chain and microbiological quality of crude sesame oil, a case study in western tigray, Ethiopia Food Nutr. Sci. 12 12 2021 1306 1325 10.4236/fns.2021.1212096
87 Chaw E.E. Analysis of aflatoxin contamination in Myanmar agricultural commodities JSM Mycotoxins 67 2 2017 89 99 10.2520/myco.67_2_4
88 Copetti M.V. Iamanaka B.T. Pitt J.I. Taniwaki M.H. Fungi and mycotoxins in cocoa: from farm to chocolate Int. J. Food Microbiol. 178 2014 13 20 10.1016/j.ijfoodmicro.2014.02.023 24667314
89 Meijer N. Kleter G. de Nijs M. Rau M.-L. Derkx R. van der Fels-Klerx H.J. The aflatoxin situation in Africa: systematic literature review Compr. Rev. Food Sci. Food Saf. 20 3 2021 2286 2304 10.1111/1541-4337.12731 33682354
90 European Commission Commission Regulation (EC) No 1881/2006 of 19 December 2006 Setting Maximum Levels for Certain Contaminants in Foodstuffs 2006 5 OJ L 364 20.12.2006
91 U.S. FDA Compliance Policy Guide Sec. 555.400 Aflatoxins in Human Food, FDA-2021-D-0242, Center for Food Safety and Applied Nutrition 2021
92 Tabata S. Mycotoxin contamination in foods and foodstuffs in Japan JSM Mycotoxins Suppl 4 2006 123 129 10.2520/myco1975.2006.Suppl4_123
93 Hosseininia A.R. Vahabzadeh M. Rashedinia M. Riahi-Zanjani B. Karimi G. A survey of aflatoxins in sesame seeds imported into Khorasan Province, Iran Mycotoxin Res. 30 1 2014 43 46 10.1007/s12550-013-0186-7 24347291
94 Esan A.O. Fapohunda S.O. Ezekiel C.N. Sulyok M. Krska R. Distribution of fungi and their toxic metabolites in melon and sesame seeds marketed in two major producing states in Nigeria Mycotoxin Res. 36 4 2020 361 369 10.1007/s12550-020-00400-0 32666399
95 Alassane-Kpembi I. Schatzmayr G. Taranu I. Marin D. Puel O. Oswald I.P. Mycotoxins co-contamination: methodological aspects and biological relevance of combined toxicity studies Crit. Rev. Food Sci. Nutr. 57 16 2017 3489 3507 10.1080/10408398.2016.1140632 26918653
96 Asadi M. Beheshti H.R. Feizy J. A survey of aflatoxins in sesame in Iran Mycotoxin Res. 27 2011 259 10.1007/s12550-011-0102-y 23605927
97 Echodu R. Maxwell Malinga G. Moriku Kaducu J. Ovuga E. Haesaert G. Prevalence of aflatoxin, ochratoxin and deoxynivalenol in cereal grains in northern Uganda: implication for food safety and health Toxicol Rep 6 2019 1012 1017 10.1016/j.toxrep.2019.09.002 31673503
98 Elaigwu M. Oluma H.O.A. Ochokwunu D.I. Eche C.O. Olasan J.O. Aflatoxin contamination levels in sesame seeds sold in Benue State, North Central Nigeria American Journal of Food Science and Health 7 2021 14 23
99 Heshmati A. Khorshidi M. Khaneghah A.M. The prevalence and risk assessment of aflatoxin in sesame-based products Ital. J. Food Sci. 33 SP1 2021 92 102 10.15586/ijfs.v33iSP1.2065
100 Kollia E. Tsourouflis K. Markaki P. Aflatoxin B1 in sesame seeds and sesame products from the Greek market Food Addit. Contam. 9 2016 217 222 10.1080/19393210.2016.1179349 Part B, Surveillance
101 Li F.-Q. Li Y.-W. Wang Y.-R. Luo X.-Y. Natural occurrence of aflatoxins in Chinese peanut butter and sesame paste J. Agric. Food Chem. 57 9 2009 3519 3524 10.1021/jf804055n 19338351
102 Makun H.A. Adeniran A.L. Mailafiya S.C. Ayanda I.S. Mudashiru A.T. Ojukwu U.J. Jagaba A.S. Usman Z. Salihu D.A. Natural occurrence of ochratoxin A in some marketed Nigerian foods Food Control 31 2 2013 566 571 10.1016/j.foodcont.2012.09.043
103 Reddy K.R. Farhana N.I. Salleh B. Occurrence of Aspergillus spp. and aflatoxin B1 in Malaysian foods used for human consumption J. Food Sci. 76 2011 T99 T104 10.1111/j.1750-3841.2011.02133.x 22417376
104 Sabry B.A. Hathout A.S. Nooh A. Aly S.E. Shehata M.G. The prevalence of aflatoxin and Aspergillus parasiticus in Egyptian sesame seeds Int. J. ChemTech Res. 9 11 2016 308 319
105 Sebaei A.S. Refai H.M. Elbadry H.T. Armeya S.M. First risk assessment report of aflatoxins in Egyptian tahini J. Food Compos. Anal. 92 2020 103550 10.1016/j.jfca.2020.103550
106 Bui-Klimke T.R. Wu F. Ochratoxin A and human health risk: a review of the evidence Crit. Rev. Food Sci. Nutr. 55 2015 1860 1869 10.1080/10408398.2012.724480 24874522
107 EFSA Panel on Contaminants in the Food Chain Risk assessment of ochratoxin A in food EFSA J. 18 5 2020 e06113 10.2903/j.efsa.2020.6113
108 Chilaka C.A. Obidiegwu J.E. Chilaka A.C. Atanda O.O. Mally A. Mycotoxin regulatory status in Africa: a decade of weak institutional efforts Toxins 14 7 2022 442 10.3390/toxins14070442 35878180
109 Hassan A. Mohamed I.A. Elkhatim K. Elagib R.A.A. Mahmoud N.S. Mohamed M.M. Salih A.M. Fadimu G. Controlling fungal growth in sesame (Sesamum indicum L.) seeds with γ-irradiation: impacts on some properties of sesame oil Grasas Aceites 70 2019 308 10.3989/gya.0933182
110 Nicolopoulou-Stamati P. Maipas S. Kotampasi C. Stamatis P. Hens L. Chemical pesticides and human health: the urgent need for a new concept in agriculture Front. Public Health 4 2016 10.3389/fpubh.2016.00148
111 Shinde R. Pardeshi A. Dhanshetty M. Anastassiades M. Banerjee K. Development and validation of an analytical method for the multi-residue analysis of pesticides in sesame seeds using liquid- and gas chromatography with tandem mass spectrometry J. Chromatogr. A 1652 2021 462346 10.1016/j.chroma.2021.462346
112 Cabrera L.C. Pastor P.M. The 2020 European Union report on pesticide residues in food EFSA J. 20 3 2022 10.2903/j.efsa.2022.7215
113 International Agency for Research on Cancer Ethylene oxide Chemical Agents and Related Occupations. A Review of Human Carcinogens. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans 100F 2012 379 396
114 European Commission Commission Regulation (EC) No 396/2005 of 23 February 2005 on Maximum Residue Levels of Pesticides in or on Food and Feed of Plant and Animal Origin and Amending Council Directive 91/414/EEC 2005 1 (OJ L 70, 16.3.2005
115 European Commission Commission Regulation (EC) No 1272/2008 of 16 December 2008 on Classification, Labelling and Packaging of Substances and Mixtures, Amending and Repealing Directives 67/548/EEC and 1999/45/EC, and Amending Regulation (EC) No 1907/2006 2008 1 OJ L 353, 31.12.2008
116 European CommissionWindow R.A.S.F.F. Notification 2024.228. Pesticide residues above MRL in sesame seeds from Nigeria https://webgate.ec.europa.eu/rasff-window/screen/notification/672925 2024 May 2024
117 Bhatnagar A. Gupta A. Chlorpyriphos, quinalphos, and lindane residues in sesame seed and oil (Sesamum indicum L.) Bull. Environ. Contam. Toxicol. 60 4 1998 596 600 10.1007/s001289900667 9557198
118 Om A.S. Chung K.W. Ko Y.S. Pesticide residues in marketed sesame Bull. Environ. Contam. Toxicol. 61 6 1998 716 721 10.1007/s001289900820 9870999
119 European Commission RASFF Window. Notification 2021.3569 Ethylene oxide in caramelised nuts with sesame seeds (almond, hazelnut and peanut) from Greece, with raw material from Nigeria, dispatched from Turkey https://webgate.ec.europa.eu/rasff-window/screen/notification/486412 2024 May 2024
120 European Commission RASFF window. Notification 2021.0207 Ethylene Oxide in Sesame Used in Baking Mixes from Germany 2024 https://webgate.ec.europa.eu/rasff-window/screen/notification/460887 May 2024
121 European Commission RASFF window. Notification 2021.0934 Ethylene oxide in sesame seeds and spice mixes with sesame seeds 2024 https://webgate.ec.europa.eu/rasff-window/screen/notification/467439 May 2024
122 European Commission RASFF Window. Notification 2020.5954. Unauthorised substance ethylene oxide in sesame seeds used in bread baking mixes from The Netherlands https://webgate.ec.europa.eu/rasff-window/screen/notification/457454 2024 May 2024
123 European CommissionWindow R.A.S.F.F. Notification 2021.5070 2-Chloroethanol in sesame seeds from Nigeria, used in baking mixes from Germany https://webgate.ec.europa.eu/rasff-window/screen/notification/504160 2024 May 2024
124 Gangur V. Kelly C. Navuluri L. Sesame allergy: a growing food allergy of global proportions? Ann. Allergy Asthma Immunol. 95 2005 4 44 10.1016/S1081-1206(10)61181-7 16095135
125 Saf S. Borres M. Sodergren E. Sesame allergy in children: new insights into diagnosis and management Pediatr. Allergy Immunol. 34 2023 e14001 10.1111/pai.14001
126 Garkaby J. Epov L. Musallam N. Almog M. Bamberger E. Mandelberg A. Dalal I. Kessel A. The sesame-peanut conundrum in Israel: reevaluation of food allergy prevalence in young children J. Allergy Clin. Immunol. Pract. 9 2021 200 205 10.1016/j.jaip.2020.08.010 32822919
127 Gangur V. Acharya H.G. The global rise and the complexity of sesame allergy: prime time to regulate sesame in the United States of America? Allergies 1 1 2021 1 21 10.3390/allergies1010001
128 Dalal I. Goldberg M. Katz Y. Sesame seed food allergy Curr. Allergy Asthma Rep. 12 2012 339 345 10.1007/s11882-012-0267-2 22610362
129 Weiss S. Smith D. Open sesame: shedding light on an emerging global allergen Ann. Allergy Asthma Immunol. 130 1 2023 40 45 10.1016/j.anai.2022.08.002 35973653
130 Sheikh F. Amin R. Rehan Khaliq A.M. Al Otaibi T. Al Hashim S. Al Gazlan S. First study of pattern of anaphylaxis in a large tertiary care hospital in Saudi Arabia Asia Pacific Allergy 5 2015 216 221 10.5415/apallergy.2015.5.4.216 26539404
131 Kahveci M. Koken G. M Şahiner Ü. Soyer Ö. Şekerel B.E. Immunoglobulin E-mediated food allergies differ in East mediterranean children aged 0-2 years Int. Arch. Allergy Immunol. 181 2020 365 374 10.1159/000505996 32097952
132 Adatia A. Clarke A.E. Yanishevsky Y. Ben-Shoshan M. Sesame allergy: current perspectives J. Asthma Allergy 10 2017 141 151 10.2147/JAA.S113612 28490893
133 Gupta R.S. Warren C.M. Smith B.M. Jiang J. Blumenstock J.A. Davis M.M. Schleimer R.P. Nadeau K.C. Prevalence and severity of food allergies among US adults JAMA Netw. Open 2 2019 e185630 10.1001/jamanetworkopen.2018.5630
134 Sokol K. Rasooly M. Dempsey C. Lassiter S. Gu W. Lumbard K. Frischmeyer-Guerrerio P.A. Prevalence and diagnosis of sesame allergy in children with IgE-mediated food allergy Paediatric Allergy and Immunology 31 2020 214 218 10.1111/pai.13143
135 Rosenberg K. Todd B. The burden of U.S. Sesame allergies may be higher than previously believed AJN 119 2019 53 10.1097/01.NAJ.0000605372.06947.85
136 Institute of Agriculture and Natural Resources Food Allergens - International Regulatory Chart 2024 https://farrp.unl.edu/IRChart July 2024
137 FAO and WHO, Risk Assessment of Food Allergens Part 1 – review and validation of Codex Alimentarius priority allergen list through risk assessment Food Safety and Quality Series 14 2022 10.4060/cb9070en
138 Hossny E. Ebisawa M. El-Gamal Y. Arasi S. Dahdah L. El-Owaidy R. Galvan C.A. Lee B.W. Challenges of managing food allergy in the developing world The World Allergy Organization Journal 12 2019 100089 10.1016/j.waojou.2019.100089
139 Data Bridge Global sesame seeds market – industry trends and forecast to 2029 https://www.databridgemarketresearch.com/reports/global-sesame-seeds-market 2022 July 2024
140 Thakali A. MacRae J.D. A review of chemical and microbial contamination in food: what are the threats to a circular food system? Environ. Res. 194 2021 110635 10.1016/j.envres.2020.110635
141 Degraeve S. Madege R.R. Audenaert K. Kamala A. Ortiz J. Kimanya M. Tiisekwa B. De Meulenaer B. Haesaert G. Impact of local pre-harvest management practices in maize on the occurrence of Fusarium species and associated mycotoxins in two agro-ecosystems in Tanzania Food Control 59 2016 225 233 10.1016/j.foodcont.2015.05.028
142 United Nations Industrial Development Organization (UNIDO) Promoting good practices in the sesame value chain for improved quality and enhanced market access https://standardsfacility.org/sites/default/files/Best_practices_guides_sesame_value_chain_actors_Sudan.pdf 2021 July 2024
143 Gebregergis Z. Baraki F. Fiseseha D. Effects of environmental factors and storage periods on sesame seed quality and longevity CABI Agric Biosci 5 2024 47 10.1186/s43170-024-00247-w
144 Bradford K.J. Dahal P. Van Asbrouck J. Kunusoth K. Bello P. Thompson J. Wu F. The dry chain: reducing postharvest losses and improving food safety in humid climates Trends Food Sci. Technol. 71 2018 84 93 10.1016/j.tifs.2017.11.002
145 Murdock L.L. Baoua I.B. On Purdue Improved Cowpea Storage (PICS) technology: background, mode of action, future prospects J. Stored Prod. Res. 58 2014 3 11 10.1016/j.jspr.2014.02.006
146 De Bruin T. Villers P. Wagh A. Narvarro S. Worldwide use of hermetic storage for the preservation of agricultural products 9th International Controlled Atmosphere & Fumigation Conference 2012
147 Baributsa D. Baoua I.B. Hermetic bags maintain soybean seed quality under high relative humidity environments J. Stored Prod. Res. 96 2022 101952 10.1016/j.jspr.2022.101952
148 Williams S.B. Murdock L.L. Baributsa D. Storage of maize in Purdue improved crop storage (PICS) bags PLoS One 12 1 2017 e0168624 10.1371/journal.pone.0168624
149 Alemayehu S. Abera F.A. Ayimut K.M. Darnell R. Mahroof R. Harvey J. Subramanyam B. Effects of storage duration and structures on sesame seed germination, mold growth, and mycotoxin accumulation Toxins 15 1 2023 39 10.3390/toxins15010039 36668858
