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Afr J Paediatr Surg
Afr J Paediatr Surg
AJPS
Afr J Paediatr Surg
African Journal of Paediatric Surgery: AJPS
0189-6725
0974-5998
Wolters Kluwer - Medknow India

AJPS-21-213
10.4103/ajps.ajps_125_22
Letter to the Editor
Aggressive Osteosarcoma of the Mandible in a 13-Year-Old Girl
Qureshi Sajid S. 12
Sharma Vivekanand 1
1 Department of Surgical Oncology, Division of Paediatric Surgical Oncology, Tata Memorial Hospital and Advanced Centre for Training Research and Education in Cancer, Tata Memorial Centre, Mumbai, Maharashtra, India
2 Homi Bhabha National Institute, Mumbai, Maharashtra, India
Address for correspondence: Prof. Sajid S. Qureshi, Department of Surgical Oncology, Division of Paediatric Surgical Oncology, Tata Memorial Hospital and Advanced Centre for Training Research and Education in Cancer, Tata Memorial Centre, Ernest Borges Road, Parel, Mumbai - 400 012, Maharashtra, India. E-mail: sajidshafiques@hotmail.com
Jul-Sep 2024
14 3 2024
21 3 213214
07 9 2022
10 2 2023
09 3 2023
Copyright: © 2024 African Journal of Paediatric Surgery
2024
https://creativecommons.org/licenses/by-nc-sa/4.0/ This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
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pmcA 13-year-old girl presented with painful swelling on the lower jaw for 9 months [Figure 1]. The swelling was neglected and treated symptomatically only. Clinical examination revealed a proliferative mass from the lower jaw completely filling the oral cavity. Computed tomography scan showed destruction of the middle-third of the mandible and an associated large mass with dislodgement of the incisors [Figure 2]. Biopsy confirmed the lesion as high-grade osteosarcoma. Positron emission tomography scan showed active localised disease only. Subsequent to neoadjuvant chemotherapy based on the institutional protocol for osteosarcoma (ifosfamide, cisplatin and doxorubicin), the patient had stable disease. A middle-third mandibulectomy was performed, and the defect was reconstructed with free vascularised fibular osteocutaneous flap [Figure 3]. The post-operative histopathology confirmed an osteosarcoma with all the bony and soft tissue margins negative for the presence of tumour. The patient received adjuvant chemotherapy and radiotherapy (70 Gy). However, there was local recurrence even before the completion of chemotherapy. In view of the aggressive disease, only the best supportive care was offered. The patient and her family palliative and supportive care needs were evaluated by the institutional multidisciplinary team of palliative care specialist, psychologists and social workers. The physical issues of pain and anxiety were addressed with drugs, while the psychological and social issues involved counselling, honest communication and support groups.

Figure 1 Clinical photograph showing a large proliferative lesion arising from the lower jaw filling the oral cavity

Figure 2 Computed tomogram images showing destruction of middle-third of the mandible with associated soft tissue mass and uprooted tooth within it

Figure 3 Intraoperative photograph showing the surgical defect (a) and the resected specimen (b) after middle-third mandibulectomy. Reconstruction with free fibular osteocutaneous flap for the surgical defect was performed (c)

The patient died two months after discharge from the hospital.

Osteosarcoma is the most common primary malignant bone tumour in children and is histologically characterised by the production of malignant osteoid. They arise from primitive mesenchymal elements and affect the long bones. Although the mandible comprises only 0.86% of total skeletal volume, osteosarcoma of the mandible constitutes 5%–13% of all osteosarcoma.[1] Due to the rarity of this tumour, the incidence in children is not known, and most studies have clubbed paediatric and adult patients together. Jaw osteosarcoma affects the mandible and the maxilla with almost equal incidence in the two bones and without any gender predominance. In the mandible, the tumour more commonly involves the body. The most common presenting symptoms are swelling with or without pain, loosening of teeth and ulceration. The patients commonly suffer for 3–4 months before seeking treatment, and the mean size of the tumour at presentation has been reported to be 4.5–8 cm. In view of the aggressive nature of the disease, most patients merit a multidisciplinary approach. Radical surgery to achieve wide negative margins with functional reconstruction is the historical mainstay. The addition of chemotherapy in the adjuvant or the neo-adjuvant setting has been shown to improve disease-free survival, especially osteosarcoma of the mandible and in the presence of positive resection margins.[23] Although thought to be radioresistant, there is evidence to support the use of 60–66 Gy of radiation in cases undergoing incomplete resection or resection with close margins.[4] Due to the rarity of osteosarcoma of the mandible in children, data regarding a biological difference in the nature of the disease in terms of aggressiveness and response to therapy compared to adults are deficient. Nonetheless, delayed presentation and the aggressive nature of the disease may be responsible for an early relapse while on chemotherapy and fatal outcome in our patient.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form, the patient has given her consent for her images and other clinical information to be reported in the journal. The patient understands that name and initials will not be published, and due efforts will be made to conceal her identity, but anonymity cannot be guaranteed.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.
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REFERENCES

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