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World J Clin Cases
WJCC
World Journal of Clinical Cases
2307-8960
Baishideng Publishing Group Inc

jWJCC.v12.i25.pg5784
10.12998/wjcc.v12.i25.5784
95153
Case Report
Sinonasal teratocarcinosarcoma involving the nasal cavity, unilateral paranasal sinuses, and intracranial invasion: A case report
Fu LY et al. Sinonasal teratocarcinosarcoma with intracranial extension
Fu Li-Yuan Department of Radiology, 900th Hospital of Joint Logistics Support Force, Fuzhou 350025, Fujian Province, China

Yang Mi-Yang The First Clinical Medical College, Fuzong Teaching Hospital, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, Fujian Province, China

Ye Pei-Yun The First Clinical Medical College, Fuzong Teaching Hospital, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, Fujian Province, China

Wang Zhao-Chu The First Clinical Medical College, Fuzong Teaching Hospital, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, Fujian Province, China

Chen Chu-Jie The First Clinical Medical College, Fuzong Teaching Hospital, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, Fujian Province, China

Li Hui Department of Radiology, 900th Hospital of Joint Logistics Support Force, Fuzhou 350025, Fujian Province, China. 582788441@qq.com

Xu Shang-Wen Department of Radiology, 900th Hospital of Joint Logistics Support Force, Fuzhou 350025, Fujian Province, China

Co-corresponding authors: Hui Li and Shang-Wen Xu.

Author contributions: Fu LY, Ye PY and Yang MY contributed to manuscript writing and editing, and data collection; Wang ZC and Chen CJ contributed to data analysis; Li H and Xu SW contributed to conceptualization and supervision; all authors have read and approved the final manuscript.

Corresponding author: Hui Li, MD, Doctor, Department of Radiology, 900th Hospital of Joint Logistics Support Force, No. 156 North West Second Ring Road, Fuzhou 350025, Fujian Province, China. 582788441@qq.com

6 9 2024
6 9 2024
12 25 57845790
2 4 2024
22 5 2024
24 6 2024
©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
2024
https://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
BACKGROUND

Sinonasal teratocarcinosarcoma (SNTCS) is a rare and highly invasive neoplasm originating from the nasal cavity and sinuses. Typically, it exhibits an invasive behavior towards adjacent structures; however, in exceptional instances, it may infiltrate the intracranial compartment. Due to the tumor's rarity and lack of distinctive features on computed tomography (CT) and magnetic resonance imaging (MRI) images, SNTCS is often misdiagnosed.

CASE SUMMARY

In this study, we present a case of SNTCS in a 56-year-old patient who exhibited unexplained cognitive impairment before admission. CT and MRI scans revealed the presence of a mass in the right nasal cavity, with lesions extending to the right ethmoid sinus and right frontal region. Subsequently, the patient underwent pathological examination for confirmation and received surgical intervention to excise the tumor. The future advancement in our understanding of this disease will significantly contribute to the precise diagnosis and treatment of SNTCS.

CONCLUSION

SNTCS is an exceptionally rare malignant tumor that originates from the nasal cavity and paranasal sinuses, presenting a diagnostic challenge due to its non-specific imaging findings. MRI accurately delineates the location, morphological characteristics, size, internal structure, extent of surrounding involvement, and metabolic information of the lesion. These aspects play a pivotal role in the precise localization and qualitative assessment of SNTCS. Nevertheless, a definitive diagnosis still requires a pathological biopsy.

Paranasal sinus
Malignant tumor
Sinonasal teratocarcinosarcoma
Brain invasion
Case report
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pmc Core Tip: We present a case report of Sinonasal teratocarcinosarcoma involving the nasal cavity, unilateral paranasal sinuses, and extending into the intracranial region in pathology. Our findings underscore the crucial role of integrating radiology results, clinical manifestations, and pathological biopsy outcomes for accurate diagnosis by clinicians.

INTRODUCTION

Sinonasal teratocarcinosarcoma (SNTCS) is a rare malignant tumor characterized by the coexistence of both teratoma and carcinosarcoma features within its composition, primarily affecting the nasal cavity and sinuses[1,2]. This disease mainly manifests in the nasal cavity and sinuses, with occasional reports of tumors occurring in other anatomical sites such as the nasopharynx, oral cavity, and even intracranially[3-7]. Clinical manifestations of tumors include: (1) Nasal obstruction and hyposmia resulting from local tumor growth; (2) Epistaxis, fetid odor in the nasal cavity, and increased nasal secretions due to rapid tumor growth leading to necrosis; and (3) Invasion of adjacent tissues by the tumor can result in facial edema, lacrimation, proptosis, visual impairment, headaches, alterations in consciousness and behavior. Physical examination may reveal a nasal mass with an ill-defined morphology that cannot be distinguished from polyps or papillomas. The disease typically follows a relatively short course, lasting 2-10 weeks but occasionally extending up to 2 years[3,8-11]. Shanmugaratnam et al[12] and Heffner et al[13] respectively conducted the description and final nomenclature of SNTCS in 1983 and 1984[12,13]. According to reports, patients with SNTCS have an average survival duration of 1.7 years, accompanied by a three-year mortality rate of 60%[13,14]. Currently, to the best of our knowledge, only approximately 150 cases have been reported, with intracranial involvement observed in a limited subset of these cases. In this study, we present a rare case involving the ethmoidal sinus and intracranial region in SNTCS, elucidating the computed tomography (CT) and magnetic resonance imaging (MRI) findings alongside histopathological analysis. We aim to contribute valuable insights for future clinical diagnosis and treatment strategies.

CASE PRESENTATION

Chief complaints

A 56-year-old male presented with an acute and unexplained impairment of consciousness four hours ago, which necessitated a referral to the emergency department of our hospital.

History of present illness

The primary manifestations included unresponsiveness to stimuli and failure to awaken upon stimulation, accompanied by generalized limb and head tremors, tightly clenched teeth, and frothing at the mouth. These symptoms lasted for approximately 1-2 minutes before spontaneously resolving themselves. After regaining consciousness, the patient reported having a headache and feeling uncomfortable. Subsequently, he was transported by ambulance to the 900th Hospital of the Joint Logistics Support Force for a comprehensive assessment and medical treatment.

History of past illness

The patient had no prior medical history. Personal and family histories revealed no relevant information. During the examination of the nervous system, no discernible abnormalities were observed in the patient.

Personal and family history

The patient had no relevant personal or family medical history.

Physical examination

The patient's physical examination revealed no evident abnormalities.

Laboratory examinations

Macroexamination revealed a mass of gray-white and gray-brown tissue measuring 7 cm × 5 cm × 1.5 cm, which was soft with some areas of necrosis. Under low magnification of hematoxylin-eosin stain, the examined tissues appeared as solid sheets with an abundance of blood vessels in the stroma, accompanied by large hemorrhages and necrotic areas. The primitive neuroepithelial cells were arranged in nests and surrounded by abundant fibrous septa (Figure 1A). In the tumor, there were glandular epithelial structures present along with focal nests of squamous epithelial components. The cytoplasm appeared transparent without any signs of keratinization (Figure 1B). Localized patchy glandular epithelium structures were also observed (Figure 1C). Under high magnification, tumor cells exhibited significant heterogeneity, with easily visible nuclear division figures (Figure 1D).

Figure 1 Pathological analysis of a sinonasal teratocarcinosarcoma. A: Low magnification of hematoxylin-eosin stain showing the overall variegated appearance (40 ×); B: Glandular epithelial structures were seen within the tumor as well as focal nested squamous epithelial components, with translucent cytoplasm and no keratinization (100 ×); C: Localized patchy glandular epithelium structures were seen in localized lesion location (100 ×); D: Under high magnification, tumor cells exhibited significant heterogeneity, with readily observable nuclear division figures (400 ×).

The immunohistochemical staining revealed varying degrees of positivity for neuroendocrine markers (Syn, and CD99 positive) in primitive neuroepithelial cells, while epithelial markers (CK-pan, epithelial membrane antigen, and p40 positive) also showed varying degrees of positivity (Figure 2A-E). Mesenchymal markers (Vimentin positive) were observed in the stromal component (Figure 2F). Ki-67 exhibited 40% positivity, whereas tumor cell MyoD1 was negative (Figure 2G and H). Based on the pathological and immunohistochemical findings, a diagnosis of SNTC was established.

Figure 2 The tumor and neural epithelia were negative. A: Syn; B: CD99; C: CK-pan; D: Epithelial membrane antigen; E: P40; F: Vimentin; G: MyoD1; H: 40% positive for Ki-67.

Imaging examinations

The CT scan reveals a mass-like, slightly hyperdense shadow in the right nasal cavity and frontal region with a measured CT value of approximately 35 HU on the plain scan. During the arterial phase, it measures around 43 HU, and during the venous phase, it increases to about 66 HU indicating significant enhancement. Additionally, surrounding edema formation is also observed. The septum exhibits leftward deviation while the lesion affects the right ethmoid sinus (Figure 3A and B). CT bone window shows multiple bone destruction in the bilateral skull base and ethmoid sinus wall (Figure 3C). MRI reveals a heterogeneous mass with abnormal signals in both the right nasal cavity and forehead region. T2WI demonstrates equal to slightly high signal intensity whereas T1WI shows slightly low signal intensity. FLAIR demonstrates a slightly increased signal while diffusion-weighted imaging also exhibits slight hyperintensity (Figure 3D-K). Following contrast-enhanced imaging, the lesion displays evident heterogeneous enhancement. The adjacent brain gyri demonstrate displacement due to compression from the lesion accompanied by perilesional edema and infiltration. The lesion involves the right ethmoidal sinus (Figure 3L and M).

Figure 3 Computed tomography and magnetic resonance imaging scan images. A: Axial enhanced computed tomography (CT) scan revealed an irregularly enhanced tumor resembling a mass in the right frontal region; B: Coronal enhanced CT scan revealed a polypoid mass with expansive growth in the right nasal cavity, extending intracranially across the cribriform plate; C: Sagittal CT bone window revealed multiple bone destruction in bilateral skull base and ethmoid sinus wall; D-K: Magnetic resonance imaging (MRI) scan reveals a mass-like abnormal signal in the right nasal cavity and right frontal region, characterized by slightly increased signal intensity on T2-weighted images, slightly decreased signal intensity on T1-weighted images, unevenly slightly increased signal intensity on FLAIR images, and slightly increased signal intensity on diffusion-weighted imaging. There is hyperintensity in the frontal lobe adjacent to tumor (vasogenic edema/infiltration); L and M: The enhanced MRI scan revealed a diffusely heterogeneous mass with enhanced contrast in the right nasal cavity, infiltrating into the cranial cavity beyond the cribriform plate.

FINAL DIAGNOSIS

Combined with the patient's medical history, the final diagnosis was SNTCS involving the nasal cavity, unilateral paranasal sinuses, and an extension into the intracranial region.

TREATMENT

Although there is currently no specific therapeutic regimen available for this disease, it has been recommended that the patient undergo intervention resection of malignant tumors in the anterior skull base and reconstruction of the skull base using a combined transnasal and transcranial approach following a comprehensive evaluation. During the nasal endoscopy examination, it was observed that there was tumor infiltration and excessive secretions in the right nasal cavity, with the tumor firmly adhered to the skull base. Under general anesthesia, most of the tumor was removed through nasal endoscopy with a plasma knife. The tumor was completely separated from the top of the ethmoid sinus along its bony surface, and then cleaning of both ethmoid and sphenoid sinuses was performed. Afterward, the opening of the middle turbinate took place followed by coverage of the entire cranial base defect in an upward direction. The nasal cavity was filled with a gelatin sponge; medical gauze was compressed on top while the gelatin sponge was dilated at the bottom.

OUTCOME AND FOLLOW-UP

At 6 months postoperatively, the patient was still alive.

DISCUSSION

The SNTCS is an extremely rare malignant neoplasm that affects the nasal cavity and sinuses. It is characterized by its highly invasive nature and unfavorable prognosis[15]. This tumor mainly originates in the nasal cavity and often extends into the sinuses, with a preference for involvement of the ethmoid sinus and sphenoid sinus[16,17]. In clinical practice, the most common symptoms include nasal congestion and epistaxis. Additionally, patients may experience headaches, rhinorrhea, lacrimation, maxillary protrusion, changes in visual acuity, and olfactory dysfunction (penetration into the cribriform plate can cause anosmia)[18-20].

The majority of SNTCS primarily manifests in the nasal cavity and sinuses. However, only a limited number of literature reports have documented initial or progressive involvement extending to the orbit/cranium[3,17,21]. In this particular scenario where rapid tumor growth causes damage to surrounding structures, patients frequently experience visual impairment, headaches, cognitive confusion, and aberrant behaviors[22]. The appearance of SNTCS on CT and MRI images often lacks specificity; exhibiting similar characteristics observed in general malignant tumors located in the nasal cavity and sinuses[23], including esthesioneuroblastomas, that should be considered as a diagnostic possibility of a mass in this location demonstrating both expansible and destructive growth properties. Both CT and MRI are useful, each with its characteristics, for accurately staging tumor extent and identifying extranasal tumor invasion, which is fundamental to operative planning. The plain CT scan frequently reveals space-occupying lesions in the nasal cavity and paranasal sinuses, which may exhibit a polypoid or lobulated morphology with homogeneous or heterogeneous lesion density, without evident calcification or cystic degeneration. The enhanced scan demonstrates conspicuous uneven enhancement, while local progressive lesions can infiltrate the surrounding tissues and cause thinning or destruction of adjacent bone structures, potentially extending to invade the skull base. On MRI, T1WI typically exhibits isointense signals, while T2WI demonstrates high signal intensity. The contrast-enhanced scan reveals heterogeneous enhancement. The tumor demonstrates a significant mass effect involving the ethmoid sinus and extending beyond the cranial vault to impact the frontal lobe. Additionally, periosteal reaction and bone destruction are observed in the surrounding region. This case exemplifies the exceptional rarity and distinctiveness of SNTCS, a nasal sinus tumor that is unparalleled in its occurrence. In the field of radiology, MRI accurately depicts the precise location, morphological characteristics, size, internal structure, surrounding involvement, and metabolic activity of lesions. It plays a pivotal role in precisely localizing and qualitatively assessing SNTCS. However, due to histological heterogeneity exhibited by tumors, diagnosing SNTCS remains challenging in clinical practice. Integrating clinical manifestations with radiology imaging information and pathological biopsy remains essential for enhancing the diagnostic accuracy of this disease.

CONCLUSION

SNTCS is a clinically rare condition, with only a limited number of cases involving the central nervous system. The clinical manifestations are atypical and lack specific imaging findings; therefore, it is crucial to combine pathological biopsy as the gold standard with radiology examinations and clinical presentations for an accurate diagnosis of this disease.

Informed consent statement: The patient provided written informed consent.

Conflict-of-interest statement: All authors have no competing interests to declare.

CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).

Provenance and peer review: Unsolicited article; Externally peer reviewed.

Peer-review model: Single blind

Specialty type: Medicine, research and experimental

Country of origin: China

Peer-review report’s classification

Scientific Quality: Grade C, Grade C

Novelty: Grade B, Grade C

Creativity or Innovation: Grade B, Grade C

Scientific Significance: Grade B, Grade C

P-Reviewer: Reis F S-Editor: Liu H L-Editor: A P-Editor: Chen YX
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