
==== Front
medRxiv
MEDRXIV
medRxiv
Cold Spring Harbor Laboratory

10.1101/2024.08.20.24312308
preprint
1
Article
Disentangling the relationship between biological age and frailty in community-dwelling older Mexican adults
Fermín-Martínez Carlos A. http://orcid.org/0000-0001-5627-8851

Ramírez-García Daniel http://orcid.org/0000-0002-6899-246X

Antonio-Villa Neftali Eduardo http://orcid.org/0000-0002-6879-1078

López-Teros Miriam Teresa http://orcid.org/0000-0001-8323-3528

Seiglie Jacqueline A. http://orcid.org/0000-0001-9278-4516

Castrejón Pérez Roberto Carlos http://orcid.org/0000-0001-6081-9243

García Peña Carmen http://orcid.org/0000-0002-9380-6964

Gutiérrez-Robledo Luis Miguel http://orcid.org/0000-0002-9728-6644

Bello-Chavolla Omar Yaxmehen http://orcid.org/0000-0003-3093-937X

20 8 2024
2024.08.20.24312308https://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator.
http://medrxiv.org/lookup/doi/10.1101/2024.08.20.24312308
nihpp-2024.08.20.24312308.pdf
ABSTRACT

OBJECTIVE

Older adults have heterogeneous aging rates. Here, we explored the impact of biological age (BA) and accelerated aging on frailty in community-dwelling older adults.

METHODS

We assessed 735 community-dwelling older adults from the Coyocan Cohort. BA was measured using AnthropoAge, accelerated aging with AnthropoAgeAccel, and frailty using both Fried’s phenotype and the frailty index. We explored the association of BA and accelerated aging (AnthropoAgeAccel ≥0) with frailty at baseline and characterized the impact of both on body composition and physical function. We also explored accelerated aging as a risk factor for frailty progression after 3-years of follow-up.

RESULTS

Older adults with accelerated aging have higher frailty prevalence and indices, lower handgrip strength and gait speed. AnthropoAgeAccel was associated with higher frailty indices (β=0.0053, 95%CI 0.0027-0.0079), and increased odds of frailty at baseline (OR 1.16, 95%CI 1.09-1.25). We observed a sexual dimorphism in body composition and physical function linked to accelerated aging in non-frail participants; however, this dimorphism was absent in pre-frail/frail participants. Accelerated aging at baseline was associated with higher risk of frailty progression over time (OR 1.74, 95%CI 1.11-2.75).

CONCLUSIONS

Despite being intertwined, biological accelerated aging is largely independent of frailty in community-dwelling older adults.
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pmc
