
==== Front
medRxiv
MEDRXIV
medRxiv
Cold Spring Harbor Laboratory

10.1101/2024.08.22.24312320
preprint
1
Article
Divergent Evolution in Bilateral Prostate Cancer: a Case Study
Haas Roni http://orcid.org/0000-0003-1505-2965

Patel Yash
Liu Lydia Y.
Huang Rong Rong
Weiner Adam
Yamaguchi Takafumi N.
Agrawal Raag
Boutros Paul C. http://orcid.org/0000-0003-0553-7520

Reiter Robert E.
23 8 2024
2024.08.22.24312320https://creativecommons.org/licenses/by-nc/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.
http://medrxiv.org/lookup/doi/10.1101/2024.08.22.24312320
nihpp-2024.08.22.24312320.pdf
Multifocal prostate cancer is a prevalent phenomenon, with most cases remaining uncharacterized from a genomic perspective. A patient presented with bilateral prostate cancer. On systematic biopsy, two indistinguishable clinicopathologic lesions were detected. Whole-genome sequencing displayed somatically unrelated tumours with distinct driver CNA regions, suggesting independent origins of the two tumors. We demonstrated that similar clinicopathologic multifocal tumours, which might be interpreted as clonal disease, can in fact represent independent cancers. Genetic prognostics can prevent mischaracterization of multifocal disease to enable optimal patient management.
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pmc
