
==== Front
bioRxiv
BIORXIV
bioRxiv
2692-8205
Cold Spring Harbor Laboratory

10.1101/2024.08.15.608159
preprint
1
Article
Population Representation of the Confidence in a Decision in the Lateral Intraparietal Area of the Macaque
Zylberberg Ariel http://orcid.org/0000-0002-2572-4748

Shadlen Michael N http://orcid.org/0000-0002-2002-2210

19 8 2024
2024.08.15.608159https://creativecommons.org/licenses/by-nc/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.
http://biorxiv.org/lookup/doi/10.1101/2024.08.15.608159
nihpp-2024.08.15.608159.pdf
Confidence in a decision is the belief, prior to feedback, that one's choice is correct. In the brain, many decisions are implemented as a race between competing evidence-accumulation processes. We ask whether the neurons that represent evidence accumulation also carry information about whether the choice is correct (i.e., confidence). Monkeys performed a reaction time version of the random dot motion task. Neuropixels probes were used to record from neurons in the lateral intraparietal (LIP) area. LIP neurons with response fields that overlap the choice-target contralateral to the recording site (Tin neurons) represent the accumulation of evidence in favor of contralateral target selection. We demonstrate that shortly before a contralateral choice is reported, the population of Tin neurons contains information about the accuracy of the choice (i.e., whether the choice is correct or incorrect). This finding is unexpected because, on average, Tin neurons exhibit a level of activity before the report that is independent of reaction time and evidence strength—both strong predictors of accuracy. This apparent contradiction is resolved by examining the variability in neuronal responses across the population of Tin neurons. While on average, Tin neurons exhibit a stereotyped level of activity before a contralateral choice, many neurons depart from this average in a consistent manner. From these neurons, the accuracy of the choice can be predicted using a simple logistic decoder. The accuracy of the choice predicted from neural activity reproduces the hallmarks of confidence identified in human behavioral experiments. Therefore, neurons that represent evidence accumulation can also inform the monkey's confidence.
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pmc
