
==== Front
Integr Cancer Ther
Integr Cancer Ther
ICT
spict
Integrative Cancer Therapies
1534-7354
1552-695X
SAGE Publications Sage CA: Los Angeles, CA

10.1177/15347354241275038
10.1177_15347354241275038
Letter to the Editor
Harnessing Hyperthermia: Molecular, Cellular, and Immunological Insights for Enhanced Anticancer Therapies: Comment
https://orcid.org/0009-0002-5881-2709
Daungsupawong Hinpetch PhD 1
Wiwanitkit Viroj MD 2
1 Private Academic Consultant, Phonhong, Lao People’s Democratic Republic
2 Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences Saveetha University, Chennai, Tamil Nadu, India
Hinpetch Daungsupawong, Private Academic Consultant, Phonhong, 10000, Lao People’s Democratic Republic. Email: hinpetchdaung@gmail.com
2 9 2024
2024
23 1534735424127503831 5 2024
15 7 2024
29 7 2024
© The Author(s) 2024
2024
SAGE Publications Inc unless otherwise noted. Manuscript content on this site is licensed under Creative Commons Licenses
https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
cover-dateJanuary-December 2024
typesetterts1
==== Body
pmcDear Editor,

The publication “Harnessing Hyperthermia: Molecular, Cellular, and Immunological Insights for Enhanced Anticancer Therapies” is an interesting article.1 In general, elevating the tumor temperature to ≥39°C, often known as hyperthermia, exhibits potential as a supportive treatment for cancer treatments. The molecular and cellular impacts of hyperthermia are reviewed in this study. These effects include the inhibition of DNA repair enzymes, the induction of cell cycle arrest, the activation of apoptotic pathways, and the modification of heat shock protein expression. Furthermore, immune system activation, increased metabolic rates, and maybe enhanced immune checkpoint inhibitor potency are all caused by hyperthermia. Moreover, heat above 50°C can cause tumor antigens to be released, which can boost immune responses.

The absence of particular case studies or examples to back up the assertions made in this review about the impact of hyperthermia on immune system and cancer cell viability is one possible flaw. Furthermore, the lack of precise information in the study regarding the methodology employed in research pertaining to the effects of hyperthermia raises doubts regarding the validity and reliability of the results. It would be beneficial for future study to address the limits of the employed approaches and provide more detailed examples.

In the future, it could be beneficial for scientists to carry out additional clinical trials to assess the efficacy of hyperthermia as a cancer treatment adjuvant. In order to strengthen the immune response to malignancies, future research may concentrate on improving the administration of hyperthermic treatments. One such method would be the use of photothermal nanoparticles for targeted drug delivery and heating. Furthermore, investigating the synergistic effects of conventional cancer treatments or other immunotherapies in combination with heat may provide new insights. All things considered, more investigation and clinical testing are necessary to completely comprehend the advantages and restrictions of hyperthermia in cancer treatment.

Author Contributions: HP 50% ideas, writing, analyzing, approval.

VW 50% ideas, supervision, approval.

Data Availability Statement: There is no new data generated.

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Funding: The author(s) received no financial support for the research, authorship, and/or publication of this article.

ORCID iD: Hinpetch Daungsupawong https://orcid.org/0009-0002-5881-2709
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Reference

1 Lukácsi S Munkácsy G Győrffy B. Harnessing hyperthermia: molecular, cellular, and immunological insights for enhanced anticancer therapies. Integr Cancer Ther. 2024;23 :15347354241242094.38818970
