
==== Front
ArXiv
ArXiv
arxiv
ArXiv
2331-8422
Cornell University

arXiv:2405.15905v2
2405.15905
2
preprint
Article
Tangent space functional reconfigurations in individuals at risk for alcohol use disorder
Moghaddam Mahdi
Dzemidzic Mario
Guerrero Daniel
Liu Mintao
Alessi Jonathan
Plawecki Martin H.
Harezlak Jaroslaw
Kareken David
Goñi Joaquín
20 8 2024
arXiv:2405.15905v224 5 2024
https://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License, which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use.
http://arxiv.org/abs/2405.15905v2
nihpp-2405.15905v2.pdf
Human brain function dynamically adjusts to ever-changing stimuli from the external environment. Studies characterizing brain functional reconfiguration are nevertheless scarce. Here we present a principled mathematical framework to quantify brain functional reconfiguration when engaging and disengaging from a stop signal task (SST). We apply tangent space projection (a Riemannian geometry mapping technique) to transform functional connectomes (FCs) of 54 participants and quantify functional reconfiguration using the correlation distance of the resulting tangent-FCs. Our goal was to compare functional reconfigurations in individuals at risk for alcohol use disorder (AUD). We hypothesized that functional reconfigurations when transitioning to/from a task would be influenced by family history of alcohol use disorder (FHA) and other AUD risk factors. Multilinear regression models showed that engaging and disengaging functional reconfiguration were associated with FHA and recent drinking. When engaging in the SST after a rest condition, functional reconfiguration was negatively associated with recent drinking, while functional reconfiguration when disengaging from the SST was negatively associated with FHA. In both models, several other factors contributed to the functional reconfiguration. This study 1demonstrates that tangent-FCs can characterize task-induced functional reconfiguration, and that it is related to AUD risk.

41 pages, 9 Figures, 3 Tables, 4 Supplementary Figures, 1 Supplementary Table
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