
==== Front
medRxiv
MEDRXIV
medRxiv
Cold Spring Harbor Laboratory

10.1101/2024.09.10.24313399
preprint
1
Article
Rapid Decline of Mpox Antibody Responses Following MVA-BN Vaccination
Collier Ai-ris Y.
McMahan Katherine
Jacob-Dolan Catherine
Liu Jinyan
Borducchi Erica N
Moss Bernard
Barouch Dan H.
11 9 2024
2024.09.10.24313399https://creativecommons.org/licenses/by-nd/4.0/ This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License, which allows reusers to copy and distribute the material in any medium or format in unadapted form only, and only so long as attribution is given to the creator. The license allows for commercial use.
http://medrxiv.org/lookup/doi/10.1101/2024.09.10.24313399
nihpp-2024.09.10.24313399.pdf
Abstract

The replication-incompetent modified vaccinia Ankara-Bavarian Nordic vaccine (MVA-BN; Jynneos) was deployed during the 2022 clade IIb mpox outbreak. On August 14, 2024, the World Health Organization declared the mpox clade Ib outbreak in the Democratic Republic of the Congo a public health emergency of international concern, which has raised the question about the durability of vaccine immunity after MVA-BN vaccination. In this study, we show that the MVA-BN vaccine generated mpox serum antibody responses that largely waned after 6-12 months.
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pmc
