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ArXiv
ArXiv
arxiv
ArXiv
2331-8422
Cornell University

arXiv:2409.06811v1
2409.06811
1
preprint
Article
1D Thermoembolization Model Using CT Imaging Data for Porcine Liver
Amare Rohan
Stolley Danielle
Parrish Steve
Jacobsen Megan
Layman Rick
Santos Chimamanda
Riviere Beatrice
Fowlkes Natalie
Fuentes David
Cressman Erik
10 9 2024
arXiv:2409.06811v1https://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License, which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use.
http://arxiv.org/abs/2409.06811v1
nihpp-2409.06811v1.pdf
Objective: Innovative therapies such as thermoembolization are expected to play an important role in improvising care for patients with diseases such as hepatocellular carcinoma. Thermoembolization is a minimally invasive strategy that combines thermal ablation and embolization in a single procedure. This approach exploits an exothermic chemical reaction that occurs when an acid chloride is delivered via an endovascular route. However, comprehension of the complexities of the biophysics of thermoembolization is challenging. Mathematical models can aid in understanding such complex processes and assisting clinicians in making informed decisions. In this study, we used a Hagen Poiseuille 1D blood flow model to predict the mass transport and possible embolization locations in a porcine hepatic artery. Method: The 1D flow model was used on in vivo embolization imaging data of three pigs. The hydrolysis time constant of acid chloride chemical reaction was optimized for each pig, and LOOCV method was used to test the model's predictive ability. Conclusion: This basic model provided a balanced accuracy rate of 66.8% for identifying the possible locations of embolization in the hepatic artery. Use of the model provides an initial understanding of the vascular transport phenomena that are predicted to occur as a result of thermoembolization.
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